NRP1
entrez
8829
canonical
uniprot
O14786
canonical
ensembl
ENSG00000099250
resolver
ensp
ENSP00000363954
resolver
ensp
ENSP00000363955
resolver
ensp
ENSP00000364001
resolver
ensp
ENSP00000379317
resolver
ensp
ENSP00000567622
resolver
ensp
ENSP00000567623
resolver
ensp
ENSP00000567624
resolver
ensp
ENSP00000619920
resolver
ensp
ENSP00000653073
resolver
ensp
ENSP00000653074
resolver
ensp
ENSP00000706734
resolver
ensp
ENSP00000706737
resolver
enst
ENST00000395995
resolver
genesymbol
NRP1
resolver
genesymbol_syn
NRP
resolver
genesymbol_syn
VEGF165R
resolver
hgnc
HGNC:8004
resolver
uniprot
A8K9V7
resolver
uniprot
B0LPG9
resolver
uniprot
E9PEP6
resolver
uniprot
O60461
resolver
uniprot
Q59F20
resolver
uniprot
Q5T7F1
resolver
uniprot
Q5T7F2
resolver
uniprot
Q5T7F3
resolver
uniprot
Q6X907
resolver
uniprot
Q86T59
resolver
uniprot
Q96I90
resolver
uniprot
Q96IH5
resolver
uniprot_entry
A8K9V7_HUMAN
resolver
uniprot_entry
E9PEP6_HUMAN
resolver
uniprot_entry
NRP1_HUMAN
resolver
uniprot_entry
Q59F20_HUMAN
resolver
uniprot_entry
Q6X907_HUMAN
resolver
uniprot_sec
B0LPG9
resolver
uniprot_sec
O60461
resolver
uniprot_sec
Q5T7F1
resolver
uniprot_sec
Q5T7F2
resolver
uniprot_sec
Q5T7F3
resolver
uniprot_sec
Q86T59
resolver
uniprot_sec
Q96I90
resolver
uniprot_sec
Q96IH5
resolver
amino_acid_sequence
MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQSTYSEA
uniprot
proteins
function
FUNCTION: Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed:10688880, PubMed:9288753, PubMed:9529250). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed:19805273). It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed:10688880, PubMed:19805273, PubMed:9288753, PubMed:9529250). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed:30623799). {ECO:0000250|UniProtKB:P97333, ECO:0000269|PubMed:10688880, ECO:0000269|PubMed:19805273, ECO:0000269|PubMed:30623799, ECO:0000269|PubMed:9288753, ECO:0000269|PubMed:9529250}.; FUNCTION: (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection. {ECO:0000269|PubMed:33082293, ECO:0000269|PubMed:33082294}.; FUNCTION: [Isoform 2]: Binds VEGF-165 and may inhibit its binding to cells (PubMed:10748121, PubMed:26503042). May induce apoptosis by sequestering VEGF-165 (PubMed:10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. {ECO:0000269|PubMed:10748121, ECO:0000269|PubMed:26503042}.
uniprot
proteins
mass_dalton
103134
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Proteolytically cleaved at the cell membrane upon H.pylori infection. {ECO:0000269|PubMed:34742300}.
uniprot
proteins
protein_family
Neuropilin family
uniprot
proteins
pubmed
10520995
uniprot
proteins
pubmed
10688880
uniprot
proteins
pubmed
10748121
uniprot
proteins
pubmed
12517344
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16763549
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
17989695
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19805273
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26503042
uniprot
proteins
pubmed
26789244
uniprot
proteins
pubmed
30623799
uniprot
proteins
pubmed
33000221
uniprot
proteins
pubmed
33082293
uniprot
proteins
pubmed
33082294
uniprot
proteins
pubmed
34742300
uniprot
proteins
pubmed
36213313
uniprot
proteins
pubmed
9288753
uniprot
proteins
pubmed
9529250
uniprot
proteins
sequence_length
923
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:10688880}.; SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305|PubMed:30623799}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30623799}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:30623799}.; SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34742300}. Note=(Microbial infection) Proteolytically cleaved at the cell membrane upon H.pylori infection. {ECO:0000269|PubMed:34742300}.
uniprot
proteins
transmembrane_region
TRANSMEM 857..879; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins