Minpp1
entrez
29688
canonical
uniprot
O35217
canonical
ensembl
ENSRNOG00000011287
resolver
ensp
ENSRNOP00000015017
resolver
enst
ENSRNOT00000015017
resolver
genesymbol
Minpp1
resolver
genesymbol_syn
Minpp1-ps1
resolver
uniprot
G3V7H2
resolver
uniprot_entry
G3V7H2_RAT
resolver
uniprot_entry
MINP1_RAT
resolver
amino_acid_sequence
MLRGARSHLSASVALAAVLAAALLSSFARCSLPGRGDPVASVLSPYFGTKTRYEDVNPWLLGDPVAPRRDPELLAGTCTPVQLVALIRHGTRYPTTKQIRKLRQLQGLLQTRESVDGGSRVAAALDQWPLWYDDWMDGQLVEKGRQDMRQLALRLAALFPDLFCRENYGRLRLITSSKHRCVDSSAAFLQGLWQHYHPGLPPPDVSDMECDPPRVNDKLMRFFDHCEKFLTEVERNATALYHVEAFKTGPEMQTVLKKVAATLQVPVNNLNADLIQVAFFTCSFDLAIQGVHSPWCDVFDVDDAKVLEYLNDLKQYWKRSYGYAINSRSSCNLFQDIFLHLDKAVEQKQRSQPVSSSVILQFGHAETLLPLLSLMGYFKDKEPLTAYNFEEQVHREFRSGHIVPYASNLIFVLYHCEDAQTPQEKFQIQMLLNEKVLPLAHSQKTVALYEDLKNHYQDILQSCQTSKECNLPKVNITSDEL
uniprot
proteins
ec_number
3.1.3.62
uniprot
proteins
ec_number
3.1.3.80
uniprot
proteins
function
FUNCTION: Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology (PubMed:1653239, PubMed:9359836). Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant. By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis. May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin (By similarity). {ECO:0000250|UniProtKB:Q9UNW1, ECO:0000269|PubMed:1653239, ECO:0000269|PubMed:9359836}.
uniprot
proteins
mass_dalton
54589
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9UNW1}.
uniprot
proteins
protein_family
Histidine acid phosphatase family
uniprot
proteins
protein_family
MINPP1 subfamily
uniprot
proteins
pubmed
1653239
uniprot
proteins
pubmed
8384201
uniprot
proteins
pubmed
9359836
uniprot
proteins
pubmed
9923613
uniprot
proteins
sequence_length
481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:8384201}. Secreted {ECO:0000250|UniProtKB:Q9UNW1}. Cell membrane {ECO:0000250|UniProtKB:Q9Z2L6}. Note=Also associated with the plasma membrane in erythrocytes. {ECO:0000250|UniProtKB:Q9Z2L6}.
uniprot
proteins