SLC1A5
entrez
6510
canonical
uniprot
Q15758
canonical
ensembl
ENSG00000105281
resolver
ensp
ENSP00000397924
resolver
ensp
ENSP00000406532
resolver
ensp
ENSP00000444408
resolver
genesymbol
SLC1A5
resolver
genesymbol_syn
ASCT2
resolver
genesymbol_syn
M7V1
resolver
genesymbol_syn
RDR
resolver
genesymbol_syn
RDRC
resolver
hgnc
HGNC:10943
resolver
uniprot
A8K9H5
resolver
uniprot
B4DR77
resolver
uniprot
B4DWS4
resolver
uniprot
B7ZB81
resolver
uniprot
D0EYG6
resolver
uniprot
E9PC01
resolver
uniprot
O95720
resolver
uniprot
Q59ES3
resolver
uniprot
Q96RL9
resolver
uniprot
Q9BWQ3
resolver
uniprot
Q9UNP2
resolver
uniprot_entry
AAAT_HUMAN
resolver
uniprot_entry
Q59ES3_HUMAN
resolver
uniprot_sec
A8K9H5
resolver
uniprot_sec
B4DR77
resolver
uniprot_sec
B4DWS4
resolver
uniprot_sec
B7ZB81
resolver
uniprot_sec
D0EYG6
resolver
uniprot_sec
E9PC01
resolver
uniprot_sec
O95720
resolver
uniprot_sec
Q96RL9
resolver
uniprot_sec
Q9BWQ3
resolver
uniprot_sec
Q9UNP2
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by L-cysteine, which can either inhibit substrate influx or trigger substrate efflux without being transported itself. {ECO:0000269|PubMed:26492990}.
uniprot
proteins
amino_acid_sequence
MVADPPRDSKGLAAAEPTANGGLALASIEDQGAAAGGYCGSRDQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPAGDATVASEKESVM
uniprot
proteins
function
FUNCTION: Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed:17094966, PubMed:23756778, PubMed:26492990, PubMed:29872227, PubMed:34741534, PubMed:8702519, PubMed:39095408, PubMed:27272177). The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (PubMed:23756778, PubMed:24953180). The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (PubMed:32733894). Part of transport systems for D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons. May contribute to D-serine reabsorption at the brush border of renal proximal tubules thus modulating the dynamics of urinary versus blood D-serine levels (PubMed:17094966, PubMed:38650461). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904, PubMed:38671230). {ECO:0000250|UniProtKB:D3ZJ25, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:17094966, ECO:0000269|PubMed:23492904, ECO:0000269|PubMed:23756778, ECO:0000269|PubMed:24953180, ECO:0000269|PubMed:26492990, ECO:0000269|PubMed:27272177, ECO:0000269|PubMed:29872227, ECO:0000269|PubMed:32733894, ECO:0000269|PubMed:34741534, ECO:0000269|PubMed:38650461, ECO:0000269|PubMed:38671230, ECO:0000269|PubMed:39095408, ECO:0000269|PubMed:8702519}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. {ECO:0000269|PubMed:10051606, ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. {ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. {ECO:0000269|PubMed:10196349}.
uniprot
proteins
mass_dalton
56598
uniprot
proteins
mutagenesis
MUTAGEN 467; /note="C->R: Changes the substrate specificity toward negatively charged amino acids. Impairs L-glutamine transport and enables L-aspartate transport instead."; /evidence="ECO:0000269|PubMed:31366933
uniprot
proteins
protein_family
Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family
uniprot
proteins
protein_family
SLC1A5 subfamily
uniprot
proteins
pubmed
10051606
uniprot
proteins
pubmed
10196349
uniprot
proteins
pubmed
10708449
uniprot
proteins
pubmed
11350958
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17094966
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23492904
uniprot
proteins
pubmed
23756778
uniprot
proteins
pubmed
24953180
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26492990
uniprot
proteins
pubmed
27272177
uniprot
proteins
pubmed
28424515
uniprot
proteins
pubmed
29872227
uniprot
proteins
pubmed
31366933
uniprot
proteins
pubmed
32733894
uniprot
proteins
pubmed
34741534
uniprot
proteins
pubmed
38650461
uniprot
proteins
pubmed
38671230
uniprot
proteins
pubmed
39095408
uniprot
proteins
pubmed
8702519
uniprot
proteins
sequence_length
541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24953180, ECO:0000269|PubMed:8702519, ECO:0000305|PubMed:29872227}; Multi-pass membrane protein {ECO:0000305|PubMed:29872227}. Apical cell membrane {ECO:0000250|UniProtKB:P51912}; Multi-pass membrane protein {ECO:0000305|PubMed:29872227}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Restricted to the apical cell membrane of proximal tubule epithelial cells. {ECO:0000250|UniProtKB:P51912, ECO:0000269|PubMed:17081065}.
uniprot
proteins
transmembrane_region
TRANSMEM 52..81; /note="Helical; Name=1"; /evidence="ECO:0000305|PubMed:29872227"; TRANSMEM 95..116; /note="Helical; Name=2"; /evidence="ECO:0000305|PubMed:29872227"; TRANSMEM 131..153; /note="Helical; Name=3"; /evidence="ECO:0000305|PubMed:29872227"; TRANSMEM 225..248; /note="Helical; Name=4"; /evidence="ECO:0000305|PubMed:29872227"; TRANSMEM 258..285; /note="Helical; Name=5"; /evidence="ECO:0000305|PubMed:29872227"; TRANSMEM 307..328; /note="Helical; Name=6"; /evidence="ECO:0000305|PubMed:29872227"; TRANSMEM 374..400; /note="Helical; Name=7"; /evidence="ECO:0000305|PubMed:29872227"; TRANSMEM 461..482; /note="Helical; Name=8"; /evidence="ECO:0000305|PubMed:29872227
uniprot
proteins