Myc
entrez
24577
canonical
uniprot
P09416
canonical
ensembl
ENSRNOG00000004500
resolver
ensembl
ENSRNOG00055023910
resolver
ensembl
ENSRNOG00060003990
resolver
ensembl
ENSRNOG00065004691
resolver
ensp
ENSRNOP00000006188
resolver
ensp
ENSRNOP00055033365
resolver
ensp
ENSRNOP00060005003
resolver
ensp
ENSRNOP00065004679
resolver
enst
ENSRNOT00055041035
resolver
enst
ENSRNOT00060006663
resolver
enst
ENSRNOT00065006804
resolver
genesymbol
Myc
resolver
uniprot
A0A8L2Q2H7
resolver
uniprot
Q6B500
resolver
uniprot_entry
MYC_RAT
resolver
uniprot_sec
A0A8L2Q2H7
resolver
uniprot_sec
Q6B500
resolver
amino_acid_sequence
MNFLWEVENPTVTTMPLNVSFANRNYDLDYDSVQPYFICDEEENFYHQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVATSFSPREDDDGGGGNFSTADQLEMMTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSTSLSPARGHSVCSTSSLYLQDLTAAASECIDPSVVFPYPLNDSSSPKSCTSSDSTAFSSSSDSLLSSESSPRATPEPLVLHEETPPTTSSDSEEEQDDEEEIDVVSVEKRQPPAKRSESGSSPSRGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRAKLDSGRVLKQISNNRKCSSPRSSDTEENDKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQADEHKLISEKDLLRKRREQLKHKLEQLRNSGA
uniprot
proteins
function
FUNCTION: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes (PubMed:17304222). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (By similarity). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity). {ECO:0000250|UniProtKB:P01106, ECO:0000250|UniProtKB:P01108, ECO:0000269|PubMed:17304222}.
uniprot
proteins
mass_dalton
50561
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKDC (By similarity). Phosphorylation at Ser-343 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-76 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-76 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-72. Phosphorylation at Thr-72 and Ser-76 by GSK3 is required for ubiquitination and degradation by the proteasome. Dephosphorylation at multiple sites by the PNUTS-PP1 complex promotes MYC stability by preventing ubiquitination by the SCF(FBXW7) complex. Dephosphorylation at Ser-76 by protein phosphatase 2A (PPP2CA) promotes its degradation; interaction with PPP2CA is enhanced by AMBRA1 (By similarity). {ECO:0000250|UniProtKB:P01106, ECO:0000250|UniProtKB:P01108}.; PTM: Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-72 and Ser-76, leading to its degradation by the proteasome. Ubiquitination is counteracted by USP28 in the nucleoplasm and USP36 in the nucleolus, both interacting with of FBXW7, leading to its deubiquitination and preventing degradation. Also polyubiquitinated by the DCX(TRPC4AP) complex. Ubiquitinated by UBR5 when not forming a heterodimer with another bHLH protein, leading to its degradation: UBR5 recognizes and binds a degron that is only available upon heterodimer dissociation (By similarity). Ubiquitinated by TRIM6 in a phosphorylation-independent manner. {ECO:0000250|UniProtKB:P01106, ECO:0000250|UniProtKB:P01108}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17304222
uniprot
proteins
pubmed
20352099
uniprot
proteins
pubmed
3277717
uniprot
proteins
pubmed
3306601
uniprot
proteins
pubmed
35244724
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P01106}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P01106}. Nucleus {ECO:0000250|UniProtKB:P01106}. Cytoplasm {ECO:0000250|UniProtKB:P01106}. Chromosome {ECO:0000250|UniProtKB:P01106}. Note=Association with chromatin is reduced by hyperphosphorylation. Localization to the nucleolus is dependent on HEATR1. {ECO:0000250|UniProtKB:P01106}.
uniprot
proteins