POLR2D
entrez
5433
canonical
uniprot
O15514
canonical
ensembl
ENSG00000144231
resolver
ensp
ENSP00000272645
resolver
enst
ENST00000272645
resolver
genesymbol
POLR2D
resolver
hgnc
HGNC:9191
resolver
uniprot
Q52LT4
resolver
uniprot_entry
RPB4_HUMAN
resolver
uniprot_sec
Q52LT4
resolver
amino_acid_sequence
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKRSFQY
uniprot
proteins
function
FUNCTION: Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2D/RPB4 is part of a subcomplex with POLR2G/RPB7 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA. {ECO:0000250|UniProtKB:P20433, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:9852112}.
uniprot
proteins
mass_dalton
16311
uniprot
proteins
protein_family
Eukaryotic RPB4 RNA polymerase subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16282592
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
27193682
uniprot
proteins
pubmed
30190596
uniprot
proteins
pubmed
9528765
uniprot
proteins
pubmed
9852112
uniprot
proteins
sequence_length
142
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9852112}.
uniprot
proteins