ARHGAP24
entrez
83478
canonical
uniprot
Q8N264
canonical
ensembl
ENSG00000138639
resolver
ensp
ENSP00000264343
resolver
ensp
ENSP00000378610
resolver
ensp
ENSP00000378611
resolver
ensp
ENSP00000425589
resolver
genesymbol
ARHGAP24
resolver
genesymbol_syn
FILGAP
resolver
hgnc
HGNC:25361
resolver
uniprot
Q4KMG1
resolver
uniprot
Q6ZNV3
resolver
uniprot
Q86TI5
resolver
uniprot
Q86WE4
resolver
uniprot
Q9H0T6
resolver
uniprot_entry
RHG24_HUMAN
resolver
uniprot_sec
Q4KMG1
resolver
uniprot_sec
Q6ZNV3
resolver
uniprot_sec
Q86TI5
resolver
uniprot_sec
Q86WE4
resolver
uniprot_sec
Q9H0T6
resolver
amino_acid_sequence
MEENNDSTENPQQGQGRQNAIKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQLQNKENNNTKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHKLDVSRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSVQNGTVRMGILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRLSTYDNVHQQFSMMNLDDKQSIDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPPQDDLSHPRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGELTVEPRRTERGNTIWIQ
uniprot
proteins
function
FUNCTION: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}.
uniprot
proteins
mass_dalton
84258
uniprot
proteins
mutagenesis
MUTAGEN 175; /note="R->A: Loss of function."; /evidence="ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138"; MUTAGEN 175; /note="R->K: Does not abolish the effect on actin stress fibers but moderates its capability to induce membrane protrusions."; /evidence="ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ROCK, leading to activate the RacGAP activity. {ECO:0000269|PubMed:16862148}.
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12601173
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15254788
uniprot
proteins
pubmed
15302923
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15611138
uniprot
proteins
pubmed
16862148
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
748
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions.
uniprot
proteins