Coxfa4
entrez
17992
canonical
uniprot
Q62425
canonical
ensembl
ENSMUSG00000029632
resolver
ensp
ENSMUSP00000144932
resolver
ensp
ENSMUSP00000145413
resolver
enst
ENSMUST00000204714
resolver
enst
ENSMUST00000204978
resolver
genesymbol
Coxfa4
resolver
genesymbol_syn
Ndufa4
resolver
uniprot
Q9CQP6
resolver
uniprot_entry
CXFA4_MOUSE
resolver
uniprot_sec
Q9CQP6
resolver
amino_acid_sequence
MLRQILGQAKKHPSLIPLFVFIGAGGTGAALYVMRLALFNPDVSWDRKNNPEPWNKLGPNEQYKFYSVNVDYSKLKKEGPDF
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. COXFA4 is required for complex IV maintenance. {ECO:0000250|UniProtKB:O00483}.
uniprot
proteins
mass_dalton
9327
uniprot
proteins
protein_family
Complex IV COXFA4 subunit family
uniprot
proteins
pubmed
11994422
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22902835
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
32973183
uniprot
proteins
pubmed
9064319
uniprot
proteins
sequence_length
82
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:O00483}; Single-pass membrane protein {ECO:0000250|UniProtKB:O00483}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..37; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O00483
uniprot
proteins