P27812
uniprot
P27812
canonical
amino_acid_sequence
MDSTTLVYADLNLARIQEPKHDSPPSLSPDTCRCPRWHRLALKFGCAGLILLVLVVIGLCVLVLSVQKSSVQKICADVQENRTHTTDCSVNLECPQDWLSHRDKCFRVFQVSNTWEEGQADCGRKGATLLLIQDQEELRFLLDSIKEKYNSFWIGLRFTLPDMNWKWINGTTFNSDVLKITGDTENGSCASISGDKVTSESCSTDNRWICQKELNHETPSNDS
uniprot
proteins
function
FUNCTION: Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent 'missing-self' recognition of allografts, tumor cells and virus-infected cells. {ECO:0000269|PubMed:10229823, ECO:0000269|PubMed:10229828, ECO:0000269|PubMed:14990792}.
uniprot
proteins
mass_dalton
25158
uniprot
proteins
mutagenesis
MUTAGEN 6; /note="L->S: Loss of inhibition of Ca(2+) influx upon activation of natural killer cells."; /evidence="ECO:0000269|PubMed:15814704"; MUTAGEN 8; /note="Y->F: Loss of PTPN6 binding and inhibition of Ca(2+) influx upon activation of natural killer cells."; /evidence="ECO:0000269|PubMed:15814704"; MUTAGEN 32; /note="C->S: Loss of Klrb1b-mediated inhibition of natural killer cell cytotoxicity. Reduced LCK binding, loss of PTPN6 binding and loss of inhibition of Ca(2+) influx upon activation of natural killer cells."; /evidence="ECO:0000269|PubMed:15814704
uniprot
proteins
pubmed
10229823
uniprot
proteins
pubmed
10229828
uniprot
proteins
pubmed
14990792
uniprot
proteins
pubmed
1517565
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15814704
uniprot
proteins
pubmed
16751398
uniprot
proteins
pubmed
1880421
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 44..63; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins