Ninj2
entrez
29862
canonical
uniprot
Q9JL89
canonical
ensembl
ENSMUSG00000041377
resolver
ensp
ENSMUSP00000046306
resolver
ensp
ENSMUSP00000108331
resolver
enst
ENSMUST00000035244
resolver
enst
ENSMUST00000112711
resolver
genesymbol
Ninj2
resolver
uniprot
F8WIJ3
resolver
uniprot
Q3TQA7
resolver
uniprot_entry
F8WIJ3_MOUSE
resolver
uniprot_entry
NINJ2_MOUSE
resolver
uniprot_entry
Q3TQA7_MOUSE
resolver
amino_acid_sequence
MESDRETIHLQHRHSMRGGNQRIDLNFYATKKSVAESMLDVALFMSNAMRLKSVLQQGPFAEYYTTLVTLIIVSLLLQVVISLLLVFIAILNLNEVENQRHLNKLNNAATILVFITVVINIFITAFGAHHAASMAARTSSNPI
uniprot
proteins
function
FUNCTION: Its role in unclear. In contrast to NINJ1 paralog, does not mediate plasma membrane rupture (cytolysis) downstream of necroptotic and pyroptotic programmed cell death. While it is able to oligomerize and form filaments, filaments are curved toward the intracellular space, preventing circularization to mediate plasma membrane rupture. May act as a homophilic transmembrane adhesion molecule involved in nerve regeneration. Promotes axonal growth. {ECO:0000250|UniProtKB:Q9NZG7}.
uniprot
proteins
mass_dalton
15994
uniprot
proteins
protein_family
Ninjurin family
uniprot
proteins
pubmed
10627596
uniprot
proteins
sequence_length
143
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NZG7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NZG7}.
uniprot
proteins
transmembrane_region
TRANSMEM 62..93; /note="Helical; Name=Helix alpha3"; /evidence="ECO:0000250|UniProtKB:Q9NZG7"; TRANSMEM 98..127; /note="Helical;Name=Helix alpha4"; /evidence="ECO:0000250|UniProtKB:Q9NZG7
uniprot
proteins