HTR5A
entrez
3361
canonical
uniprot
P47898
canonical
ensembl
ENSG00000157219
resolver
ensp
ENSP00000287907
resolver
enst
ENST00000287907
resolver
genesymbol
HTR5A
resolver
hgnc
HGNC:5300
resolver
uniprot
A4D2N2
resolver
uniprot
Q2M2D2
resolver
uniprot_entry
5HT5A_HUMAN
resolver
uniprot_entry
A4D2N2_HUMAN
resolver
uniprot_sec
Q2M2D2
resolver
amino_acid_sequence
MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35610220, PubMed:35835867, PubMed:9865521). Also functions as a receptor for ergot alkaloid derivatives and other psychoactive substances (PubMed:35835867). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35610220, PubMed:35835867, PubMed:9865521). HTR5A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:35610220, PubMed:35835867, PubMed:9865521). {ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:35835867, ECO:0000269|PubMed:9865521}.
uniprot
proteins
mass_dalton
40255
uniprot
proteins
mutagenesis
MUTAGEN 121; /note="D->A: Abolished G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35610220"; MUTAGEN 142; /note="S->A: Does not affect G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35835867"; MUTAGEN 143; /note="I->A: Strongly decreased G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35835867"; MUTAGEN 147; /note="M->I: Does not affect G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35835867"; MUTAGEN 154; /note="R->A: Abolished G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35835867"; MUTAGEN 204; /note="S->C: Decreased G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35835867"; MUTAGEN 223; /note="I->A: Strongly decreased G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35835867"; MUTAGEN 226..227; /note="AA->VL: Strongly increased G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35835867"; MUTAGEN 226; /note="A->V: Strongly increased G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35835867"; MUTAGEN 227; /note="A->L: Increased G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35835867"; MUTAGEN 230; /note="R->A: Slightly decreased G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35835867"; MUTAGEN 282; /note="R->A: Strongly decreased G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35835867"; MUTAGEN 284; /note="A->R: Strongly increased G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35835867"; MUTAGEN 286; /note="M->A: Slightly decreased G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35835867"; MUTAGEN 287; /note="V->A: Abolished G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35835867"; MUTAGEN 305; /note="E->A: Increased G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35610220"; MUTAGEN 342; /note="N->A: Strongly decreased G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35835867
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
35610220
uniprot
proteins
pubmed
35835867
uniprot
proteins
pubmed
7988681
uniprot
proteins
pubmed
9865521
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9865521}; Multi-pass membrane protein {ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:35835867}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..63; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:35835867, ECO:0007744|PDB:7UM4, ECO:0007744|PDB:7X5H"; TRANSMEM 77..103; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:35835867, ECO:0007744|PDB:7UM4, ECO:0007744|PDB:7X5H"; TRANSMEM 115..137; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:35835867, ECO:0007744|PDB:7UM4, ECO:0007744|PDB:7X5H"; TRANSMEM 156..176; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:35835867, ECO:0007744|PDB:7UM4, ECO:0007744|PDB:7X5H"; TRANSMEM 199..220; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:35835867, ECO:0007744|PDB:7UM4, ECO:0007744|PDB:7X5H"; TRANSMEM 288..312; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:35835867, ECO:0007744|PDB:7UM4, ECO:0007744|PDB:7X5H"; TRANSMEM 315..339; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:35835867, ECO:0007744|PDB:7UM4, ECO:0007744|PDB:7X5H
uniprot
proteins