TLK1
entrez
9874
canonical
uniprot
Q9UKI8
canonical
ensembl
ENSG00000198586
resolver
ensp
ENSP00000387313
resolver
ensp
ENSP00000409222
resolver
ensp
ENSP00000411099
resolver
ensp
ENSP00000428113
resolver
ensp
ENSP00000549122
resolver
ensp
ENSP00000724315
resolver
enst
ENST00000409443
resolver
genesymbol
TLK1
resolver
genesymbol_syn
KIAA0137
resolver
hgnc
HGNC:11841
resolver
uniprot
B3KR15
resolver
uniprot
B3KRP1
resolver
uniprot
B4DX87
resolver
uniprot
F6XMW8
resolver
uniprot
Q14150
resolver
uniprot
Q8N591
resolver
uniprot
Q9NYH2
resolver
uniprot
Q9Y4F6
resolver
uniprot_entry
B3KRP1_HUMAN
resolver
uniprot_entry
F6XMW8_HUMAN
resolver
uniprot_entry
TLK1_HUMAN
resolver
uniprot_sec
B3KR15
resolver
uniprot_sec
B4DX87
resolver
uniprot_sec
Q14150
resolver
uniprot_sec
Q8N591
resolver
uniprot_sec
Q9NYH2
resolver
uniprot_sec
Q9Y4F6
resolver
activity_regulation
ACTIVITY REGULATION: Cell-cycle regulated, maximal activity in S-phase. Inactivated by phosphorylation at Ser-743, potentially by CHEK1. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:12660173}.
uniprot
proteins
amino_acid_sequence
MSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}.
uniprot
proteins
mass_dalton
86700
uniprot
proteins
mutagenesis
MUTAGEN 607; /note="D->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414"; MUTAGEN 743; /note="S->A: Loss of kinase inhibition in response to DNA damage."; /evidence="ECO:0000269|PubMed:12660173"; MUTAGEN 743; /note="S->D: Loss of kinase inhibition in response to DNA damage."; /evidence="ECO:0000269|PubMed:12660173"; MUTAGEN 743; /note="S->E: Loss of kinase inhibition in response to DNA damage."; /evidence="ECO:0000269|PubMed:12660173
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
10523312
uniprot
proteins
pubmed
10588641
uniprot
proteins
pubmed
11314006
uniprot
proteins
pubmed
11470414
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12660173
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29955062
uniprot
proteins
pubmed
33323470
uniprot
proteins
pubmed
8590280
uniprot
proteins
pubmed
9427565
uniprot
proteins
sequence_length
766
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:9427565}.
uniprot
proteins