Habp2
entrez
226243
canonical
uniprot
Q8K0D2
canonical
ensembl
ENSMUSG00000025075
resolver
ensp
ENSMUSP00000077402
resolver
ensp
ENSMUSP00000093641
resolver
ensp
ENSMUSP00000364767
resolver
enst
ENSMUST00000078284
resolver
enst
ENSMUST00000095948
resolver
genesymbol
Habp2
resolver
uniprot
E9QM92
resolver
uniprot
F7BMY4
resolver
uniprot
Q3UEI7
resolver
uniprot
Q3V1J8
resolver
uniprot_entry
E9QM92_MOUSE
resolver
uniprot_entry
F7BMY4_MOUSE
resolver
uniprot_entry
HABP2_MOUSE
resolver
uniprot_entry
Q3UEI7_MOUSE
resolver
uniprot_entry
Q3V1J8_MOUSE
resolver
amino_acid_sequence
MFVRMLVFRVLLLIALVGKSVIGLSLMSFIAPPDPDWTPDDYYYSYEQSSPDEDPSVTQTTPENPDWYYEDDDPCQSNPCEHGGDCIIRGDTFSCSCPAPFSGSRCQTAQNKCKDNPCVHGDCLITQKHPYYRCACKYPYTGPDCSKVLPACRPNPCQNGGVCSRHRRRSRFTCACPDQYKGKFCEIGPDDCYVGDGYSYRGKVSKTVNQNPCLYWNSHLLLQETYNMFMEDAETHGIAEHNFCRNPDGDHKPWCFVKVNSEKVKWEYCDVTVCPVPDTPNPVESLLEPVMELPGFESCGKTEVAEHAVKRIYGGFKSTAGKHPWQVSLQTSLPLTTSMPQGHFCGGALIHPCWVLTAAHCTDINTKHLKVVLGDQDLKKTESHEQTFRVEKILKYSQYNERDEIPHNDIALLKLKPVGGHCALESRYVKTVCLPSDPFPSGTECHISGWGVTETGEGSRQLLDAKVKLIANPLCNSRQLYDHTIDDSMICAGNLQKPGSDTCQGDSGGPLTCEKDGTYYVYGIVSWGQECGKKPGVYTQVTKFLNWIKTTMHREAGL
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII. May function as a tumor suppressor negatively regulating cell proliferation and cell migration. {ECO:0000250|UniProtKB:Q14520}.
uniprot
proteins
mass_dalton
62357
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain (HC) and cleavage at Arg-311 or Lys-317 can give rise to the 27 kDa light chain (LC). The HC can undergo further proteolytic cleavage giving rise to a 26 kDa fragment. The LC can undergo further proteolytic cleavage at Arg-311 leading to a 17-kDa fragment and at Arg-478 leading to a 8-kDa fragment. {ECO:0000250|UniProtKB:Q14520}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9401717
uniprot
proteins
sequence_length
558
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q14520}. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form. {ECO:0000250|UniProtKB:Q14520}.
uniprot
proteins