BACE2
entrez
25825
canonical
uniprot
Q9Y5Z0
canonical
ensembl
ENSG00000182240
resolver
ensp
ENSP00000327528
resolver
ensp
ENSP00000332979
resolver
ensp
ENSP00000333854
resolver
genesymbol
BACE2
resolver
genesymbol_syn
AEPLC
resolver
genesymbol_syn
ALP56
resolver
genesymbol_syn
ASP21
resolver
hgnc
HGNC:934
resolver
uniprot
A8K7P1
resolver
uniprot
Q5DIH8
resolver
uniprot
Q8N2D4
resolver
uniprot
Q9H2V8
resolver
uniprot
Q9NZL1
resolver
uniprot
Q9NZL2
resolver
uniprot
Q9UJT6
resolver
uniprot_entry
BACE2_HUMAN
resolver
uniprot_sec
A8K7P1
resolver
uniprot_sec
Q5DIH8
resolver
uniprot_sec
Q8N2D4
resolver
uniprot_sec
Q9H2V8
resolver
uniprot_sec
Q9NZL1
resolver
uniprot_sec
Q9NZL2
resolver
uniprot_sec
Q9UJT6
resolver
amino_acid_sequence
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
uniprot
proteins
ec_number
3.4.23.45
uniprot
proteins
function
FUNCTION: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 (PubMed:10591213, PubMed:11083922, PubMed:11423558, PubMed:15857888, PubMed:16816112). Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets (PubMed:23754390). Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142). {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:11083922, ECO:0000269|PubMed:11423558, ECO:0000269|PubMed:15857888, ECO:0000269|PubMed:16816112, ECO:0000269|PubMed:21907142, ECO:0000269|PubMed:23754390}.
uniprot
proteins
mass_dalton
56180
uniprot
proteins
mutagenesis
MUTAGEN 110; /note="D->A,N: Loss of autoproteolytic cleavage."; /evidence="ECO:0000269|PubMed:10838186, ECO:0000269|PubMed:11316808"; MUTAGEN 303; /note="D->A: Loss of autoproteolytic cleavage."; /evidence="ECO:0000269|PubMed:10838186
uniprot
proteins
post_translational_modification
PTM: Undergoes autoproteolytic cleavage. {ECO:0000269|PubMed:11316808, ECO:0000269|PubMed:11423558}.; PTM: Glycosylated. {ECO:0000269|PubMed:10683441, ECO:0000269|PubMed:11083922}.
uniprot
proteins
protein_family
Peptidase A1 family
uniprot
proteins
pubmed
10591213
uniprot
proteins
pubmed
10677483
uniprot
proteins
pubmed
10683441
uniprot
proteins
pubmed
10749877
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
10838186
uniprot
proteins
pubmed
10965118
uniprot
proteins
pubmed
11083922
uniprot
proteins
pubmed
11316808
uniprot
proteins
pubmed
11423558
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15857888
uniprot
proteins
pubmed
16305800
uniprot
proteins
pubmed
16816112
uniprot
proteins
pubmed
16965550
uniprot
proteins
pubmed
21907142
uniprot
proteins
pubmed
23754390
uniprot
proteins
sequence_length
518
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21907142}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000269|PubMed:11423558}. Endoplasmic reticulum. Endosome. Melanosome {ECO:0000269|PubMed:23754390}. Note=Colocalizes with PMEL in stage I and II melanosomes. {ECO:0000269|PubMed:23754390}.
uniprot
proteins
transmembrane_region
TRANSMEM 474..494; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins