Grk4
entrez
14772
canonical
uniprot
O70291
canonical
ensembl
ENSMUSG00000052783
resolver
ensp
ENSMUSP00000001112
resolver
ensp
ENSMUSP00000074223
resolver
ensp
ENSMUSP00000311954
resolver
enst
ENSMUST00000001112
resolver
enst
ENSMUST00000074651
resolver
genesymbol
Grk4
resolver
genesymbol_syn
Gprk2l
resolver
uniprot
F6VHW7
resolver
uniprot
Q3V151
resolver
uniprot
Q8BP13
resolver
uniprot_entry
F6VHW7_MOUSE
resolver
uniprot_entry
GRK4_MOUSE
resolver
uniprot_entry
Q8BP13_MOUSE
resolver
uniprot_sec
Q3V151
resolver
activity_regulation
ACTIVITY REGULATION: Autophosphorylation at Ser-484 activates the protein kinase activity. Inhibited by heparin. {ECO:0000250|UniProtKB:P32298}.
uniprot
proteins
amino_acid_sequence
MELENFVANNLLLKARLGFNKQTGRSKKWRELLKFPPVSMCTELRWSIEKDFSSLCDKQPIGRLLFRQFCDTKPDLKRCIEFLDAVAEYEVTIEEEQREFGLAIFSRFFKEKSEVPLPEIPPDIVKECKWNLKQNSPSQNVFEECAGIVCKYLSETPFEEYQESTYFNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGDPGFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPEGEMVRGRVGTVGYMAPEIINHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREELERRVKNETEEYSERFSEDAKSICSMLLIKDPSKRLGCQRDGVSAVKQHPIFKDINFSRLEANMLDPPFIPDPQAIYCRNILDIGQFSVVKGVNLDTNDEIFYAEFATGSVTIPWQNEMIESGCFKDLNENEDDLSSLEKYKMCSSILRPKRNFFRRLFRRTGCLNIALSEEREPTEH
uniprot
proteins
ec_number
2.7.11.16
uniprot
proteins
function
FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors, such as ADRB2, DRD1 and DRD3. Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization. Mediates phosphorylation of DRD1 in the absence of dopamine activation, resulting in constitutive desensitization. {ECO:0000250|UniProtKB:P32298}.
uniprot
proteins
mass_dalton
66928
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated at Ser-484 activates the protein kinase activity. {ECO:0000250|UniProtKB:P32298}.; PTM: Palmitoylated. {ECO:0000250|UniProtKB:P32298}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
GPRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10506199
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P32298}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P32298}. Note=Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells. {ECO:0000250|UniProtKB:P32298}.
uniprot
proteins