PLAAT1
entrez
57110
canonical
uniprot
Q9HDD0
canonical
ensembl
ENSG00000127252
resolver
ensp
ENSP00000264735
resolver
ensp
ENSP00000523329
resolver
ensp
ENSP00000523334
resolver
ensp
ENSP00000797934
resolver
genesymbol
PLAAT1
resolver
genesymbol_syn
HRASLS
resolver
hgnc
HGNC:14922
resolver
uniprot
D2KX19
resolver
uniprot
Q6X7C0
resolver
uniprot
Q86WS9
resolver
uniprot
X6R3D1
resolver
uniprot_entry
PLAT1_HUMAN
resolver
uniprot_sec
D2KX19
resolver
uniprot_sec
Q6X7C0
resolver
uniprot_sec
Q86WS9
resolver
uniprot_sec
X6R3D1
resolver
amino_acid_sequence
MAFNDCFSLNYPGNPCPGDLIEVFRPGYQHWALYLGDGYVINIAPVDGIPASFTSAKSVFSSKALVKMQLLKDVVGNDTYRINNKYDETYPPLPVEEIIKRSEFVIGQEVAYNLLVNNCEHFVTLLRYGEGVSEQANRAISTVEFVTAAVGVFSFLGLFPKGQRAKYY
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
3.1.1.32
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:21880860, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:21880860, PubMed:22825852, PubMed:27623847). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:21880860). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE) which serves as precursor for N-acylethanolamines (NAEs) (PubMed:21880860, PubMed:22825852, PubMed:27623847). {ECO:0000269|PubMed:21880860, ECO:0000269|PubMed:22825852, ECO:0000269|PubMed:27623847, ECO:0000303|PubMed:26503625}.
uniprot
proteins
mass_dalton
18750
uniprot
proteins
protein_family
H-rev107 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
21880860
uniprot
proteins
pubmed
22825852
uniprot
proteins
pubmed
26503625
uniprot
proteins
pubmed
27623847
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:27623847}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:27623847}. Cytoplasm {ECO:0000269|PubMed:27623847}.
uniprot
proteins
transmembrane_region
TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins