Fam89b
entrez
309170
canonical
uniprot
Q566R4
canonical
ensembl
ENSRNOG00000024239
resolver
ensembl
ENSRNOG00055021782
resolver
ensembl
ENSRNOG00060031593
resolver
ensembl
ENSRNOG00065033888
resolver
ensp
ENSRNOP00000016987
resolver
genesymbol
Fam89b
resolver
genesymbol_syn
Lrap25
resolver
genesymbol_syn
Mtvr2
resolver
uniprot_entry
LRA25_RAT
resolver
amino_acid_sequence
MNGLPSTEAPGGAGCALAGLPPLPRGLSGLLNASGGSWRELERVYSQRSRIHDELSRAARAPDGPRHAAGSANLGSAAGPRRPVNLDSALAALRKEMVGLRQLDMSLLCQLWGLYESIQDYKHLCQDLSLCQDLSSSLHSDSSYPPDAGLSDDDEPPDASLPPDPPPLTVPQTHNARDQWLQDAFQISL
uniprot
proteins
function
FUNCTION: Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. {ECO:0000250|UniProtKB:Q9QUI1}.
uniprot
proteins
mass_dalton
20169
uniprot
proteins
protein_family
FAM89 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25107909
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QUI1}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9QUI1}. Note=Co-localizes with CDC42BPA, CDC42BPB and LIMK1 in the lamellipodium. {ECO:0000250|UniProtKB:Q9QUI1}.
uniprot
proteins