Fzd7
entrez
14369
canonical
uniprot
Q61090
canonical
ensembl
ENSMUSG00000041075
resolver
ensp
ENSMUSP00000109884
resolver
enst
ENSMUST00000114246
resolver
genesymbol
Fzd7
resolver
uniprot
G3X953
resolver
uniprot
Q810L8
resolver
uniprot
Q9CUZ6
resolver
uniprot_entry
FZD7_MOUSE
resolver
uniprot_entry
Q810L8_MOUSE
resolver
uniprot_entry
Q9CUZ6_MOUSE
resolver
uniprot_sec
G3X953
resolver
amino_acid_sequence
MRGPGTAASHSPLGLCALVLALLGALPTDTRAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGAGGSPTAYPTAPYLPDPPFTAMSPSDGRGRLSFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFSPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. Activation by WNT8 induces expression of beta-catenin target genes. Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G proteins by CCDC88C and triggering of non-canonical Wnt responses (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. {ECO:0000250|UniProtKB:O75084, ECO:0000269|PubMed:10097073, ECO:0000269|PubMed:15353129}.
uniprot
proteins
mass_dalton
63733
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
10097073
uniprot
proteins
pubmed
10395542
uniprot
proteins
pubmed
15195140
uniprot
proteins
pubmed
15353129
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8626800
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10097073, ECO:0000269|PubMed:15353129}; Multi-pass membrane protein {ECO:0000269|PubMed:10097073, ECO:0000269|PubMed:15353129}. Endosome membrane {ECO:0000250|UniProtKB:O75084}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O75084}. Note=Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions. {ECO:0000250|UniProtKB:O75084}.
uniprot
proteins
transmembrane_region
TRANSMEM 255..275; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 287..307; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 335..355; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 378..398; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 422..442; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 469..489; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 527..547; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins