NAP1L4
entrez
4676
canonical
uniprot
Q99733
canonical
ensembl
ENSG00000205531
resolver
ensembl
ENSG00000273562
resolver
ensp
ENSP00000369915
resolver
ensp
ENSP00000436397
resolver
ensp
ENSP00000481412
resolver
ensp
ENSP00000537829
resolver
ensp
ENSP00000537834
resolver
ensp
ENSP00000537835
resolver
ensp
ENSP00000537837
resolver
ensp
ENSP00000605472
resolver
ensp
ENSP00000677947
resolver
ensp
ENSP00000677951
resolver
ensp
ENSP00000677954
resolver
ensp
ENSP00000677961
resolver
ensp
ENSP00000788209
resolver
genesymbol
NAP1L4
resolver
genesymbol_syn
NAP2
resolver
hgnc
HGNC:7640
resolver
uniprot
B2R6J4
resolver
uniprot
F5HFY4
resolver
uniprot_entry
NP1L4_HUMAN
resolver
uniprot_sec
B2R6J4
resolver
uniprot_sec
F5HFY4
resolver
amino_acid_sequence
MADHSFSDGVPSDSVEAAKNASNTEKLTDQVMQNPRVLAALQERLDNVPHTPSSYIETLPKAVKRRINALKQLQVRCAHIEAKFYEEVHDLERKYAALYQPLFDKRREFITGDVEPTDAESEWHSENEEEEKLAGDMKSKVVVTEKAAATAEEPDPKGIPEFWFTIFRNVDMLSELVQEYDEPILKHLQDIKVKFSDPGQPMSFVLEFHFEPNDYFTNSVLTKTYKMKSEPDKADPFSFEGPEIVDCDGCTIDWKKGKNVTVKTIKKKQKHKGRGTVRTITKQVPNESFFNFFNPLKASGDGESLDEDSEFTLASDFEIGHFFRERIVPRAVLYFTGEAIEDDDNFEEGEEGEEEELEGDEEGEDEDDAEINPKV
uniprot
proteins
function
FUNCTION: Acts as a histone chaperone in nucleosome assembly. {ECO:0000269|PubMed:9325046}.
uniprot
proteins
mass_dalton
42823
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at the G0/G1 boundary but it is not phosphorylated in S-phase. Phosphorylated protein remains in the cytoplasm in a complex with histones during the G0/G1 transition, whereas dephosphorylation triggers its transport into the nucleus at the G1/S-boundary. {ECO:0000269|PubMed:10764593}.; PTM: Polyglutamylated by TTLL4, a modification that occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Some residues may also be monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human (By similarity). {ECO:0000250|UniProtKB:Q78ZA7, ECO:0000305}.
uniprot
proteins
protein_family
Nucleosome assembly protein (NAP) family
uniprot
proteins
pubmed
10764593
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29899097
uniprot
proteins
pubmed
8923002
uniprot
proteins
pubmed
9325046
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10764593, ECO:0000269|PubMed:9325046}. Chromosome {ECO:0000250|UniProtKB:Q78ZA7}. Cytoplasm {ECO:0000269|PubMed:10764593, ECO:0000269|PubMed:9325046}. Note=Present in the cytoplasm and excluded from the nucleus during G0/G1 phase, then relocates to the nucleus by the time cells are in S phase (PubMed:9325046). Phosphorylated form localizes in the cytoplasm during the G0/G1 transition, whereas dephosphorylation leads to relocalization into the nucleus at the G1/S-boundary (PubMed:10764593). {ECO:0000269|PubMed:10764593, ECO:0000269|PubMed:9325046}.
uniprot
proteins