Glrx2
entrez
69367
canonical
uniprot
Q923X4
canonical
ensembl
ENSMUSG00000018196
resolver
ensp
ENSMUSP00000107588
resolver
ensp
ENSMUSP00000121010
resolver
ensp
ENSMUSP00000121665
resolver
ensp
ENSMUSP00000141022
resolver
genesymbol
Glrx2
resolver
genesymbol_syn
Grx2
resolver
uniprot
A2A5W4
resolver
uniprot
Q3UQ95
resolver
uniprot
Q9DAG8
resolver
uniprot
Q9JHY6
resolver
uniprot_entry
A2A5W4_MOUSE
resolver
uniprot_entry
GLRX2_MOUSE
resolver
uniprot_entry
Q3UQ95_MOUSE
resolver
uniprot_sec
Q9DAG8
resolver
uniprot_sec
Q9JHY6
resolver
activity_regulation
ACTIVITY REGULATION: The 2Fe-2S present in the homodimer leads to inactivation of the enzyme. The 2Fe-2S may serve as a redox sensor: the presence of one-electron oxidants or reductants leading to the loss of the 2Fe-2S cluster, subsequent monomerization and activation of the enzyme (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MSWRRAASVGRRLVASGRILAGRRGAAGAAGSGMGNSTSSFWGKSTTTPVNQIQETISNNCVVIFSKTSCSYCSMAKKIFHDMNVNYKAVELDMLEYGNQFQDALHKMTGERTVPRIFVNGRFIGGAADTHRLHKEGKLLPLVHQCYLKKKQEERH
uniprot
proteins
function
FUNCTION: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. {ECO:0000269|PubMed:11397793, ECO:0000269|PubMed:15347644}.
uniprot
proteins
mass_dalton
17307
uniprot
proteins
protein_family
Glutaredoxin family
uniprot
proteins
pubmed
11397793
uniprot
proteins
pubmed
12954614
uniprot
proteins
pubmed
15347644
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
156
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.
uniprot
proteins