Rhoh
entrez
74734
canonical
uniprot
Q9D3G9
canonical
ensembl
ENSMUSG00000029204
resolver
ensp
ENSMUSP00000031106
resolver
ensp
ENSMUSP00000143810
resolver
ensp
ENSMUSP00000355829
resolver
enst
ENSMUST00000031106
resolver
enst
ENSMUST00000201533
resolver
genesymbol
Rhoh
resolver
genesymbol_syn
Arhh
resolver
uniprot
Q504M6
resolver
uniprot_entry
Q504M6_MOUSE
resolver
uniprot_entry
RHOH_MOUSE
resolver
amino_acid_sequence
MLSSIKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVDVFMDGIQISLGLWDTAGNDAFRSIRPLSYQQADVVLMCYSVANHNSFLNLKNKWISEIRSNLPCTPVLVVATQTDQREVGPHRASCINAIEGKRLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARRRNRRKLFSINECKIF
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils (By similarity). Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70 (PubMed:17028588). Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells. {ECO:0000250, ECO:0000269|PubMed:15494435, ECO:0000269|PubMed:17028588, ECO:0000269|PubMed:17119112, ECO:0000269|PubMed:19124738}.
uniprot
proteins
mass_dalton
21324
uniprot
proteins
mutagenesis
MUTAGEN 73; /note="Y->F: Abolishes interaction with ZAP70; when associated with F-83."; /evidence="ECO:0000269|PubMed:17028588"; MUTAGEN 83; /note="Y->F: Abolishes interaction with ZAP70; when associated with F-73."; /evidence="ECO:0000269|PubMed:17028588
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine by LCK. Phosphorylated by FYN. Phosphorylation enhances the interactions with ZAP70 and SYK and is critical for its function in thymocyte development. {ECO:0000269|PubMed:17028588}.
uniprot
proteins
protein_family
Rho family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15494435
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17028588
uniprot
proteins
pubmed
17119112
uniprot
proteins
pubmed
19124738
uniprot
proteins
pubmed
19414807
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17028588}. Cell membrane {ECO:0000269|PubMed:17028588}; Lipid-anchor {ECO:0000269|PubMed:17028588}; Cytoplasmic side {ECO:0000269|PubMed:17028588}. Note=Colocalizes together with ZAP70 in the immunological synapse.
uniprot
proteins