Il4r
entrez
16190
canonical
uniprot
P16382
canonical
ensembl
ENSMUSG00000030748
resolver
ensp
ENSMUSP00000033004
resolver
genesymbol
Il4r
resolver
genesymbol
Il4ra
resolver
genesymbol_syn
Il4ra
resolver
uniprot
O54690
resolver
uniprot
Q3U905
resolver
uniprot
Q60583
resolver
uniprot
Q8CBW5
resolver
uniprot_entry
IL4RA_MOUSE
resolver
uniprot_entry
Q3U905_MOUSE
resolver
uniprot_sec
O54690
resolver
uniprot_sec
Q60583
resolver
uniprot_sec
Q8CBW5
resolver
amino_acid_sequence
MGRLCTKFLTSVGCLILLLVTGSGSIKVLGEPTCFSDYIRTSTCEWFLDSAVDCSSQLCLHYRLMFFEFSENLTCIPRNSASTVCVCHMEMNRPVQSDRYQMELWAEHRQLWQGSFSPSGNVKPLAPDNLTLHTNVSDEWLLTWNNLYPSNNLLYKDLISMVNISREDNPAEFIVYNVTYKEPRLSFPINILMSGVYYTARVRVRSQILTGTWSEWSPSITWYNHFQLPLIQRLPLGVTISCLCIPLFCLFCYFSITKIKKIWWDQIPTPARSPLVAIIIQDAQVPLWDKQTRSQESTKYPHWKTCLDKLLPCLLKHRVKKKTDFPKAAPTKSLQSPGKAGWCPMEVSRTVLWPENVSVSVVRCMELFEAPVQNVEEEEDEIVKEDLSMSPENSGGCGFQESQADIMARLTENLFSDLLEAENGGLGQSALAESCSPLPSGSGQASVSWACLPMGPSEEATCQVTEQPSHPGPLSGSPAQSAPTLACTQVPLVLADNPAYRSFSDCCSPAPNPGELAPEQQQADHLEEEEPPSPADPHSSGPPMQPVESWEQILHMSVLQHGAAAGSTPAPAGGYQEFVQAVKQGAAQDPGVPGVRPSGDPGYKAFSSLLSSNGIRGDTAAAGTDDGHGGYKPFQNPVPNQSPSSVPLFTFGLDTELSPSPLNSDPPKSPPECLGLELGLKGGDWVKAPPPADQVPKPFGDDLGFGIVYSSLTCHLCGHLKQHHSQEEGGQSPIVASPGCGCCYDDRSPSLGSLSGALESCPEGIPPEANLMSAPKTPSNLSGEGKGPGHSPVPSQTTEVPVGALGIAVS
uniprot
proteins
function
FUNCTION: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
uniprot
proteins
mass_dalton
87627
uniprot
proteins
post_translational_modification
PTM: On IL4 binding, phosphorylated on C-terminal tyrosine residues. {ECO:0000250|UniProtKB:P24394}.; PTM: Soluble IL4R can also be produced by proteolytic cleavage at the cell surface (shedding). {ECO:0000269|PubMed:8757301}.
uniprot
proteins
protein_family
Type 4 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
12242343
uniprot
proteins
pubmed
1534014
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
2405398
uniprot
proteins
pubmed
26124135
uniprot
proteins
pubmed
2805066
uniprot
proteins
pubmed
8390454
uniprot
proteins
pubmed
8757301
uniprot
proteins
pubmed
9348299
uniprot
proteins
sequence_length
810
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 234..257; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins