Plekha3
entrez
83435
canonical
uniprot
Q9ERS4
canonical
ensembl
ENSMUSG00000002733
resolver
ensp
ENSMUSP00000107551
resolver
enst
ENSMUST00000111920
resolver
genesymbol
Plekha3
resolver
genesymbol_syn
Fapp1
resolver
uniprot_entry
PKHA3_MOUSE
resolver
amino_acid_sequence
MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHPADNTRMELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTAKEKEISETSESLKTKMSELRLYCDLLMQQVHTIQEFVHRDERHPSPSVENMNEASSLLSATCNTFITTLEECVKIANAKFKPEMFQLPHPDPLVSPVSPSPVQMMKRSASHPGSCSSERSSCSIKEPASALHRLPQRRRRTYSDTDSCNDVPPEDPERPLHCSGNTLNGDLASATIPEESRLMAKTQSEEPLLPFS
uniprot
proteins
function
FUNCTION: Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (By similarity). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (By similarity). Binds preferentially to PtdIns(4)P (By similarity). Negatively regulates APOB secretion from hepatocytes (By similarity). {ECO:0000250|UniProtKB:Q9HB20}.
uniprot
proteins
mass_dalton
33423
uniprot
proteins
pubmed
11001876
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9HB20}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9HB20}. Note=Localizes to ER-trans Golgi network (TGN) contacts sites. {ECO:0000250|UniProtKB:Q9HB20}.
uniprot
proteins