Rgs17
entrez
56533
canonical
uniprot
Q9QZB0
canonical
ensembl
ENSMUSG00000019775
resolver
ensp
ENSMUSP00000065825
resolver
ensp
ENSMUSP00000113519
resolver
ensp
ENSMUSP00000116291
resolver
ensp
ENSMUSP00000361294
resolver
enst
ENSMUST00000064225
resolver
enst
ENSMUST00000117676
resolver
enst
ENSMUST00000131996
resolver
genesymbol
Rgs17
resolver
genesymbol_syn
Rgsz2
resolver
uniprot
G5E8E0
resolver
uniprot
Q543T9
resolver
uniprot
Q8BR34
resolver
uniprot_entry
G5E8E0_MOUSE
resolver
uniprot_entry
Q8BR34_MOUSE
resolver
uniprot_entry
RGS17_MOUSE
resolver
uniprot_sec
Q543T9
resolver
amino_acid_sequence
MRKRQQSQNEGTQAVSQAPGNQRPNNTCCFCWCCCCSCSCLTVRNEERGDSSGRSPHTTKMESIQVLEECQNPTADEVLSWSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVINRSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKAFVESTTSCTSES
uniprot
proteins
function
FUNCTION: Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G proteins. {ECO:0000250|UniProtKB:Q9UGC6, ECO:0000269|PubMed:15827571, ECO:0000269|PubMed:16900103}.
uniprot
proteins
mass_dalton
24345
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated in synapsomal membranes. {ECO:0000269|PubMed:15827571}.; PTM: Serine phosphorylated in synapsomal membranes. {ECO:0000269|PubMed:16900103}.; PTM: Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (PubMed:16900103). Desumoylated by HINT1 (PubMed:31088288). {ECO:0000269|PubMed:16900103, ECO:0000269|PubMed:31088288}.
uniprot
proteins
pubmed
15827571
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16900103
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
31088288
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:15827571, ECO:0000269|PubMed:16900103}. Synapse, synaptosome {ECO:0000269|PubMed:15827571, ECO:0000269|PubMed:16900103}. Nucleus {ECO:0000269|PubMed:16900103}. Cytoplasm {ECO:0000269|PubMed:16900103}.
uniprot
proteins