Syvn1
entrez
74126
canonical
uniprot
Q9DBY1
canonical
ensembl
ENSMUSG00000024807
resolver
ensp
ENSMUSP00000114843
resolver
ensp
ENSMUSP00000114960
resolver
ensp
ENSMUSP00000196444
resolver
enst
ENSMUST00000134667
resolver
enst
ENSMUST00000138532
resolver
genesymbol
Syvn1
resolver
genesymbol_syn
Hrd1
resolver
genesymbol_syn
Kiaa1810
resolver
uniprot
A0A0R4J1R1
resolver
uniprot
Q80T88
resolver
uniprot
Q8CGB5
resolver
uniprot_entry
A0A0R4J1R1_MOUSE
resolver
uniprot_entry
SYVN1_MOUSE
resolver
uniprot_sec
Q80T88
resolver
uniprot_sec
Q8CGB5
resolver
amino_acid_sequence
MFRTAVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKVMGKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSPRFVALFTLLLFLKCFHWLAEDRVDFMERSPNISWLFHCRIVSLMFLLGILDFLFVSHAYHSILTRGASVQLVFGFEYAILMTMVLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIMIKVHTFPLFAIRPMYLAMRQFKKAVTDAIMSRRAIRNMNTLYPDATPEELQAVDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCRMDVLRASLPAQSPPPPEPADQGPPPAPHPQPLLPQPPNFPQGLLPPFPPGMFPLWPPMGPFPPVPPPPSSGEAAAPPPTSTAVSRPSGAATTTAAGTSTSAPAPGSVPGPEAGPAPGFPFPPPWMGMPLPPPFAFPPMPVPPAGFAGLTPEELRALEGHERQHLEARLQSLRNIHTLLDAAMLQINQYLTVLASLGPPRPATSVNPTEETASTVVSAAPSTSAPSSEAPTPSPGASPPIPEAEKPPAPESVGIVEELPEDGEPDAAELRRRRLQKLESPVAH
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12975321, PubMed:15611074). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12975321, PubMed:15611074). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Required for embryogenesis (PubMed:15611074). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (PubMed:21911472). During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells (PubMed:29907570). {ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:15611074, ECO:0000269|PubMed:17170702, ECO:0000269|PubMed:21911472, ECO:0000269|PubMed:29907570}.
uniprot
proteins
mass_dalton
67296
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. Deubiquitinated by USP19. {ECO:0000250|UniProtKB:Q86TM6}.
uniprot
proteins
protein_family
HRD1 family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
12975321
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15519674
uniprot
proteins
pubmed
15611074
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17059562
uniprot
proteins
pubmed
17170702
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21911472
uniprot
proteins
pubmed
27064360
uniprot
proteins
pubmed
29907570
uniprot
proteins
pubmed
30389664
uniprot
proteins
sequence_length
612
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17059562, ECO:0000269|PubMed:29907570}; Multi-pass membrane protein {ECO:0000269|PubMed:17059562}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 42..62; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 99..119; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins