PPP2R5B
entrez
5526
canonical
uniprot
Q15173
canonical
ensembl
ENSG00000068971
resolver
ensp
ENSP00000164133
resolver
ensp
ENSP00000542785
resolver
genesymbol
PPP2R5B
resolver
hgnc
HGNC:9310
resolver
uniprot
Q13853
resolver
uniprot_entry
2A5B_HUMAN
resolver
uniprot_sec
Q13853
resolver
amino_acid_sequence
METKLPPASTPTSPSSPGLSPVPPPDKVDGFSRRSLRRARPRRSHSSSQFRYQSNQQELTPLPLLKDVPASELHELLSRKLAQCGVMFDFLDCVADLKGKEVKRAALNELVECVGSTRGVLIEPVYPDIIRMISVNIFRTLPPSENPEFDPEEDEPNLEPSWPHLQLVYEFFLRFLESPDFQPSVAKRYVDQKFVLMLLELFDSEDPREREYLKTILHRVYGKFLGLRAYIRKQCNHIFLRFIYEFEHFNGVAELLEILGSIINGFALPLKTEHKQFLVRVLIPLHSVKSLSVFHAQLAYCVVQFLEKDATLTEHVIRGLLKYWPKTCTQKEVMFLGEMEEILDVIEPSQFVKIQEPLFKQVARCVSSPHFQVAERALYFWNNEYILSLIEDNCHTVLPAVFGTLYQVSKEHWNQTIVSLIYNVLKTFMEMNGKLFDELTASYKLEKQQEQQKAQERQELWQGLEELRLRRLQGTQGAKEAPLQRLTPQVAASGGQS
uniprot
proteins
function
FUNCTION: As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. {ECO:0000269|PubMed:21329884}.
uniprot
proteins
mass_dalton
57393
uniprot
proteins
mutagenesis
MUTAGEN 52; /note="Y->S: Loss of KLHL15-binding and enhanced stability."; /evidence="ECO:0000269|PubMed:23135275"; MUTAGEN 103..104; /note="KR->DE: Impaired trimer formation with PP2A subunits A/C, no effect on KLHL15-binding."; /evidence="ECO:0000269|PubMed:23135275"; MUTAGEN 232..233; /note="RK->ED: Impaired trimer formation with PP2A subunits A/C, no effect on KLHL15-binding."; /evidence="ECO:0000269|PubMed:23135275
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by E3 CUL3-KLHL15 complex; this modification leads to proteasomal degradation. {ECO:0000269|PubMed:23135275}.
uniprot
proteins
protein_family
Phosphatase 2A regulatory subunit B56 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541025
uniprot
proteins
pubmed
21329884
uniprot
proteins
pubmed
23135275
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25972378
uniprot
proteins
pubmed
30615140
uniprot
proteins
pubmed
7592815
uniprot
proteins
pubmed
8694763
uniprot
proteins
pubmed
8703017
uniprot
proteins
sequence_length
497
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8703017}.
uniprot
proteins