SLC14A1
entrez
6563
canonical
uniprot
Q13336
canonical
ensembl
ENSG00000141469
resolver
ensp
ENSP00000318546
resolver
ensp
ENSP00000385320
resolver
ensp
ENSP00000390637
resolver
ensp
ENSP00000412309
resolver
ensp
ENSP00000441998
resolver
ensp
ENSP00000465702
resolver
ensp
ENSP00000466273
resolver
ensp
ENSP00000773169
resolver
ensp
ENSP00000800854
resolver
enst
ENST00000402943
resolver
enst
ENST00000535474
resolver
enst
ENST00000589322
resolver
genesymbol
SLC14A1
resolver
genesymbol_syn
HUT11
resolver
genesymbol_syn
JK
resolver
genesymbol_syn
RACH1
resolver
genesymbol_syn
UT1
resolver
genesymbol_syn
UTE
resolver
hgnc
HGNC:10918
resolver
uniprot
A0ACM8QGA8
resolver
uniprot
A8K0P3
resolver
uniprot
B3KR62
resolver
uniprot
B3KVX3
resolver
uniprot
B4DFJ8
resolver
uniprot
B4DHU3
resolver
uniprot
C9EHF2
resolver
uniprot
E7EQN3
resolver
uniprot
F5GWS2
resolver
uniprot
M0QX00
resolver
uniprot
Q86VM5
resolver
uniprot_entry
A0ACM8QGA8_HUMAN
resolver
uniprot_entry
B4DFJ8_HUMAN
resolver
uniprot_entry
B4DHU3_HUMAN
resolver
uniprot_entry
F5GWS2_HUMAN
resolver
uniprot_entry
UT1_HUMAN
resolver
uniprot_sec
A8K0P3
resolver
uniprot_sec
B3KR62
resolver
uniprot_sec
B3KVX3
resolver
uniprot_sec
C9EHF2
resolver
uniprot_sec
E7EQN3
resolver
uniprot_sec
M0QX00
resolver
uniprot_sec
Q86VM5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by phloretin and para-chloromercuribenzene sulfonate. {ECO:0000269|PubMed:10514515, ECO:0000269|PubMed:7989337, ECO:0000269|PubMed:8997401}.
uniprot
proteins
amino_acid_sequence
MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVESPL
uniprot
proteins
function
FUNCTION: Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes (PubMed:10514515, PubMed:7797558, PubMed:7989337, PubMed:8997401). Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity). Facilitates water transport in erythrocytes (By similarity). {ECO:0000250|UniProtKB:Q8VHL0, ECO:0000269|PubMed:10514515, ECO:0000269|PubMed:7797558, ECO:0000269|PubMed:7989337, ECO:0000269|PubMed:8997401}.
uniprot
proteins
mass_dalton
42528
uniprot
proteins
protein_family
Urea transporter family
uniprot
proteins
pubmed
10514515
uniprot
proteins
pubmed
10644814
uniprot
proteins
pubmed
10942407
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18028269
uniprot
proteins
pubmed
18980618
uniprot
proteins
pubmed
23219802
uniprot
proteins
pubmed
7797558
uniprot
proteins
pubmed
7989337
uniprot
proteins
pubmed
8573795
uniprot
proteins
pubmed
8997401
uniprot
proteins
pubmed
9215669
uniprot
proteins
sequence_length
389
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10514515, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:7797558}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8VHL0}; Multi-pass membrane protein {ECO:0000255}. Note=Restricted to the basolateral membrane in various portions of the urothelium. {ECO:0000250|UniProtKB:Q8VHL0}.
uniprot
proteins
transmembrane_region
TRANSMEM 53..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 91..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 242..262; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 281..301; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 310..330; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 333..353; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins