PDE7A
entrez
5150
canonical
uniprot
Q13946
canonical
ensembl
ENSG00000205268
resolver
ensp
ENSP00000368730
resolver
ensp
ENSP00000385632
resolver
genesymbol
PDE7A
resolver
hgnc
HGNC:8791
resolver
uniprot
A0AVH6
resolver
uniprot
A8K436
resolver
uniprot
A8K9G5
resolver
uniprot
O15380
resolver
uniprot
Q96T72
resolver
uniprot_entry
PDE7A_HUMAN
resolver
uniprot_sec
A0AVH6
resolver
uniprot_sec
A8K436
resolver
uniprot_sec
A8K9G5
resolver
uniprot_sec
O15380
resolver
uniprot_sec
Q96T72
resolver
activity_regulation
ACTIVITY REGULATION: Insensitive to all selective PDE inhibitors. {ECO:0000269|PubMed:15994308}.
uniprot
proteins
amino_acid_sequence
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
uniprot
proteins
ec_number
3.1.4.53
uniprot
proteins
function
FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:19350606, PubMed:8389765, PubMed:9195912). May have a role in muscle signal transduction (PubMed:9195912). {ECO:0000269|PubMed:19350606, ECO:0000269|PubMed:8389765, ECO:0000269|PubMed:9195912}.
uniprot
proteins
mass_dalton
55505
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. {ECO:0000269|PubMed:8389765, ECO:0000269|PubMed:9195912}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE7 subfamily
uniprot
proteins
pubmed
11371644
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15470020
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15994308
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
19350606
uniprot
proteins
pubmed
8389765
uniprot
proteins
pubmed
9195912
uniprot
proteins
sequence_length
482
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform PDE7A1]: Cytoplasm, cytosol {ECO:0000269|PubMed:9195912}. Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions. {ECO:0000269|PubMed:9195912}.; SUBCELLULAR LOCATION: [Isoform PDE7A2]: Cytoplasm {ECO:0000269|PubMed:9195912}. Note=PDE7A2 (50 kDa) is located to particulate cellular fractions. {ECO:0000269|PubMed:9195912}.
uniprot
proteins