Hsd17b8
entrez
14979
canonical
uniprot
P50171
canonical
ensembl
ENSMUSG00000073422
resolver
ensp
ENSMUSP00000038069
resolver
genesymbol
Hsd17b8
resolver
genesymbol_syn
H2-Ke6
resolver
genesymbol_syn
Hke6
resolver
uniprot
Q5M9K0
resolver
uniprot
Q60958
resolver
uniprot
Q60959
resolver
uniprot
Q9Z1W2
resolver
uniprot_entry
DHB8_MOUSE
resolver
uniprot_sec
Q5M9K0
resolver
uniprot_sec
Q60958
resolver
uniprot_sec
Q60959
resolver
uniprot_sec
Q9Z1W2
resolver
amino_acid_sequence
MASQLRLRSALALVTGAGSGIGRAISVRLAAEGAAVAACDLDGAAAQDTVRLLGSPGSEDGAPRGKHAAFQADVSQGPAARRLLEEVQACFSRPPSVVVSCAGITRDEFLLHMSEEDWDRVIAVNLKGTFLVTQAAAQALVSSGGRGSIINISSIIGKVGNIGQTNYASSKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKMPEKVKDKVTAMIPLGHMGDPEDVADVVAFLASEDSGYITGASVEVSGGLFM
uniprot
proteins
ec_number
1.1.1.239
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
ec_number
1.1.1.n12
uniprot
proteins
function
FUNCTION: Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex, acts as scaffold protein, required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference, this enzymatic activity is not needed for the KAR function. Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+)(H). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters (By similarity). NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. It efficiently catalyzes the oxidation of estradiol (E2), testosterone, and dihydrotestosterone. Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active estradiol (E2) (PubMed:9712896). {ECO:0000250|UniProtKB:Q92506, ECO:0000269|PubMed:9712896}.
uniprot
proteins
mass_dalton
26588
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000250|UniProtKB:Q92506}.; PATHWAY: Steroid biosynthesis; estrogen biosynthesis. {ECO:0000269|PubMed:9712896}.; PATHWAY: Lipid metabolism; mitochondrial fatty acid beta-oxidation. {ECO:0000250|UniProtKB:Q92506}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15923359
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7559658
uniprot
proteins
pubmed
8441417
uniprot
proteins
pubmed
9712896
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q92506}.
uniprot
proteins