Fdxr
entrez
79122
canonical
uniprot
P56522
canonical
ensembl
ENSRNOG00000058497
resolver
ensembl
ENSRNOG00055032918
resolver
ensembl
ENSRNOG00060021431
resolver
ensembl
ENSRNOG00065021609
resolver
ensp
ENSRNOP00000075248
resolver
ensp
ENSRNOP00055047036
resolver
ensp
ENSRNOP00060030637
resolver
ensp
ENSRNOP00065029574
resolver
enst
ENSRNOT00000085636
resolver
enst
ENSRNOT00055056940
resolver
enst
ENSRNOT00060037143
resolver
enst
ENSRNOT00065036736
resolver
genesymbol
Fdxr
resolver
uniprot_entry
ADRO_RAT
resolver
amino_acid_sequence
MAPRCWRWWSWSAWPGVRPLPSRSTPTPGFCKKFSTQETTPQICVVGSGPAGFYTAQHLLKHHTRAHVDIYEKQLVPFGLVRFGVAPDHPEVKNVINTFTQTARSDRCAFRGNVVVGRDVSVPELREAYHAVVLSYGAEDHQPLEIPGEELPGVVSARAFVGWYNGLPENQKLAPDLSCDTAVILGQGNVALDVARILLTPPEHLEKTDITEVALGVLRQSRVKTVWIVGRRGPLQVAFTIKELREMIQLPGTQPILDPSDFLGLQDRIKDVPRPRKRLTELLLRTATEKPGVEEAARRALASRAWGLRFFRSPQQVLPTPDGRRVAGIRLAVTRLEGVGESTRAVPTGDVEDLPCGLLLSSVGYKSRPIDPSVPFDPKLGIIPNTEGRVVNAPGLYCSGWVKRGPTGVITTTMTDSFLTSQVLLKDLKAGLLPSGPRPGYTAIQALLSDRGVRPVSFSDWEKLDAEEVARGQGTGKPREKLVDRREMLQLLGH
uniprot
proteins
ec_number
1.18.1.6
uniprot
proteins
function
FUNCTION: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver (PubMed:10525147). Also acts as a ferredoxin--NADP(+) reductase essential for coenzyme Q biosynthesis: together with FDX2, transfers the electrons required for the hydroxylation reaction performed by COQ6 (By similarity). {ECO:0000250|UniProtKB:P22570, ECO:0000269|PubMed:10525147}.
uniprot
proteins
mass_dalton
54363
uniprot
proteins
pathway_participation
PATHWAY: Steroid metabolism. {ECO:0000269|PubMed:10525147}.
uniprot
proteins
protein_family
Ferredoxin--NADP reductase type 1 family
uniprot
proteins
pubmed
10525147
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
2170421
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:2170421}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins