Bud23
entrez
66138
canonical
uniprot
Q9CY21
canonical
ensembl
ENSMUSG00000005378
resolver
ensp
ENSMUSP00000071600
resolver
ensp
ENSMUSP00000083146
resolver
ensp
ENSMUSP00000106836
resolver
ensp
ENSMUSP00000331060
resolver
enst
ENSMUST00000071677
resolver
enst
ENSMUST00000085984
resolver
enst
ENSMUST00000111205
resolver
genesymbol
Bud23
resolver
genesymbol_syn
Wbscr22
resolver
uniprot
A0A1S6GWI7
resolver
uniprot
D3YYK7
resolver
uniprot
F6X2B9
resolver
uniprot
Q148S9
resolver
uniprot
Q3U915
resolver
uniprot
Q9DCT4
resolver
uniprot_entry
A0A1S6GWI7_MOUSE
resolver
uniprot_entry
BUD23_MOUSE
resolver
uniprot_entry
D3YYK7_MOUSE
resolver
uniprot_entry
F6X2B9_MOUSE
resolver
uniprot_entry
Q148S9_MOUSE
resolver
uniprot_entry
Q9DCT4_MOUSE
resolver
uniprot_sec
Q3U915
resolver
amino_acid_sequence
MASRSRRPEHSGPPELFYDQNEARKYVRNSRMIDIQTKMTERALELLCLPEGQPSYLLDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALDRDTEGDLLLGDMGQGVPFRPGSFDGCISISAVQWLCNANKKSDVPARRLYCFFSSLYSALVRGARAVLQLYPENSEQLELITTQATRAGFTGGVVVDFPNSAKAKKFYLCLFSGPSTSLPKGLTESQDADQASESMFTSERAPHKKARRDLVKKSREWVLEKKERRRRQGKEVRPDTQYTGRKRKPRF
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro. {ECO:0000250|UniProtKB:O43709}.
uniprot
proteins
mass_dalton
31587
uniprot
proteins
post_translational_modification
PTM: May be ubiquitinated and targeted to degradation in response to pro-inflammatory cytokine signaling. {ECO:0000250|UniProtKB:O43709}.
uniprot
proteins
protein_family
BUD23/WBSCR22 family
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
12073013
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43709}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P25627}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O43709}. Cytoplasm {ECO:0000250|UniProtKB:O43709}. Note=Localized diffusely throughout the nucleus and the cytoplasm. Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes. Localization is not affected by glucocorticoid treatment. {ECO:0000250|UniProtKB:O43709}.
uniprot
proteins