Cd4
entrez
24932
canonical
uniprot
P05540
canonical
ensembl
ENSRNOG00000071219
resolver
ensembl
ENSRNOG00055010716
resolver
ensembl
ENSRNOG00060032587
resolver
ensembl
ENSRNOG00065029565
resolver
ensp
ENSRNOP00000098012
resolver
ensp
ENSRNOP00055014556
resolver
ensp
ENSRNOP00060046642
resolver
ensp
ENSRNOP00065041996
resolver
enst
ENSRNOT00000120323
resolver
enst
ENSRNOT00055018114
resolver
enst
ENSRNOT00060056461
resolver
enst
ENSRNOT00065051051
resolver
genesymbol
Cd4
resolver
uniprot_entry
CD4_RAT
resolver
amino_acid_sequence
MCRGFSFRHLLPLLLLQLSKLLVVTQGKTVVLGKEGGSAELPCESTSRRSASFAWKSSDQKTILGYKNKLLIKGSLELYSRFDSRKNAWERGSFPLIINKLRMEDSQTYVCELENKKEEVELWVFRVTFNPGTRLLQGQSLTLILDSNPKVSDPPIECKHKSSNIVKDSKAFSTHSLRIQDSGIWNCTVTLNQKKHSFDMKLSVLGFASTSITAYKSEGESAEFSFPLNLGEESLQGELRWKAEKAPSSQSWITFSLKNQKVSVQKSTSNPKFQLSETLPLTLQIPQVSLQFAGSGNLTLTLDRGILYQEVNLVVMKVTQPDSNTLTCEVMGPTSPKMRLILKQENQEARVSRQEKVIQVQAPEAGVWQCLLSEGEEVKMDSKIQVLSKGLNQTMFLAVVLGSAFSFLVFTGLCILFCVRCRHQQRQAARMSQIKRLLSEKKTCQCSHRMQKSHNLI
uniprot
proteins
function
FUNCTION: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. {ECO:0000250|UniProtKB:P01730}.
uniprot
proteins
mass_dalton
51438
uniprot
proteins
mutagenesis
MUTAGEN 186; /note="N->T: No change in secretion; when associated with S-297."; /evidence="ECO:0000269|PubMed:2113054"; MUTAGEN 297; /note="N->S: No change in secretion; when associated with T-186."; /evidence="ECO:0000269|PubMed:2113054
uniprot
proteins
post_translational_modification
PTM: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. {ECO:0000250|UniProtKB:P01730}.; PTM: Phosphorylated by PKC; phosphorylation plays an important role for CD4 internalization. {ECO:0000250|UniProtKB:P01730}.
uniprot
proteins
pubmed
2113054
uniprot
proteins
pubmed
3104900
uniprot
proteins
pubmed
8493535
uniprot
proteins
sequence_length
457
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P01730}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P01730}. Note=Localizes to lipid rafts. {ECO:0000250|UniProtKB:P01730}.
uniprot
proteins
transmembrane_region
TRANSMEM 395..417; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins