P52796
uniprot
P52796
canonical
amino_acid_sequence
MARPGQRWLSKWLVAMVVLTLCRLATPLAKNLEPVSWSSLNPKFLSGKGLVIYPKIGDKLDIICPRAEAGRPYEYYKLYLVRPEQAAACSTVLDPNVLVTCNKPQQEIRFTIKFQEFSPNYMGLEFKKYHDYYITSTSNGSLEGLENREGGVCRTRTMKIVMKVGQDPNAVTPEQLTTSRPSKESDNTVKTATQAPGRGSQGDSDGKHETVNQQEKSGPGAGGSGSGDTDSFFNSKVALFAAVGAGCVIFLLIIIFLTVLLLKLRKRHRKHTQQRAAALSLSTLASPKGDSGTAGTEPSDIIIPLRTTENNYCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
uniprot
proteins
function
FUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:7936648). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (By similarity). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:7936648). Can also bind EPHB2 and EPHB3 (By similarity). Binds to, and induces the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250|UniProtKB:P52795, ECO:0000269|PubMed:7936648}.
uniprot
proteins
mass_dalton
37951
uniprot
proteins
post_translational_modification
PTM: Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. {ECO:0000250|UniProtKB:P98172}.; PTM: Proteolytically processed. The ectodomain is cleaved, probably by a metalloprotease, to produce a membrane-tethered C-terminal fragment. This fragment is then further processed by the gamma-secretase complex to yield a soluble intracellular domain peptide which can translocate to the nucleus. The intracellular domain peptide is highly labile suggesting that it is targeted for degradation by the proteasome. {ECO:0000250|UniProtKB:P98172}.
uniprot
proteins
protein_family
Ephrin family
uniprot
proteins
pubmed
10197531
uniprot
proteins
pubmed
7936648
uniprot
proteins
sequence_length
345
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:7936648}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000250|UniProtKB:P98172}. Note=May recruit GRIP1 and GRIP2 to membrane raft domains. {ECO:0000250|UniProtKB:P98172}.; SUBCELLULAR LOCATION: [Ephrin-B1 C-terminal fragment]: Cell membrane {ECO:0000250|UniProtKB:P98172}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Ephrin-B1 intracellular domain]: Nucleus {ECO:0000250|UniProtKB:P98172}. Note=Colocalizes with ZHX2 in the nucleus. {ECO:0000250|UniProtKB:P98172}.
uniprot
proteins
transmembrane_region
TRANSMEM 237..257; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins