STAT2
entrez
6773
canonical
uniprot
P52630
canonical
ensembl
ENSG00000170581
resolver
ensp
ENSP00000315768
resolver
ensp
ENSP00000450751
resolver
ensp
ENSP00000498876
resolver
ensp
ENSP00000513600
resolver
ensp
ENSP00000592448
resolver
ensp
ENSP00000630714
resolver
ensp
ENSP00000698079
resolver
ensp
ENSP00000735195
resolver
enst
ENST00000651915
resolver
genesymbol
STAT2
resolver
hgnc
HGNC:11363
resolver
uniprot
A0A494C164
resolver
uniprot
B4DLC7
resolver
uniprot
G3V2M6
resolver
uniprot
Q16430
resolver
uniprot
Q16431
resolver
uniprot
Q9UDL4
resolver
uniprot
R9QE65
resolver
uniprot_entry
A0A494C164_HUMAN
resolver
uniprot_entry
R9QE65_HUMAN
resolver
uniprot_entry
STAT2_HUMAN
resolver
uniprot_sec
B4DLC7
resolver
uniprot_sec
G3V2M6
resolver
uniprot_sec
Q16430
resolver
uniprot_sec
Q16431
resolver
uniprot_sec
Q9UDL4
resolver
amino_acid_sequence
MAQWEMLQNLDSPFQDQLHQLYSHSLLPVDIRQYLAVWIEDQNWQEAALGSDDSKATMLFFHFLDQLNYECGRCSQDPESLLLQHNLRKFCRDIQPFSQDPTQLAEMIFNLLLEEKRILIQAQRAQLEQGEPVLETPVESQQHEIESRILDLRAMMEKLVKSISQLKDQQDVFCFRYKIQAKGKTPSLDPHQTKEQKILQETLNELDKRRKEVLDASKALLGRLTTLIELLLPKLEEWKAQQQKACIRAPIDHGLEQLETWFTAGAKLLFHLRQLLKELKGLSCLVSYQDDPLTKGVDLRNAQVTELLQRLLHRAFVVETQPCMPQTPHRPLILKTGSKFTVRTRLLVRLQEGNESLTVEVSIDRNPPQLQGFRKFNILTSNQKTLTPEKGQSQGLIWDFGYLTLVEQRSGGSGKGSNKGPLGVTEELHIISFTVKYTYQGLKQELKTDTLPVVIISNMNQLSIAWASVLWFNLLSPNLQNQQFFSNPPKAPWSLLGPALSWQFSSYVGRGLNSDQLSMLRNKLFGQNCRTEDPLLSWADFTKRESPPGKLPFWTWLDKILELVHDHLKDLWNDGRIMGFVSRSQERRLLKKTMSGTFLLRFSESSEGGITCSWVEHQDDDKVLIYSVQPYTKEVLQSLPLTEIIRHYQLLTEENIPENPLRFLYPRIPRDEAFGCYYQEKVNLQERRKYLKHRLIVVSNRQVDELQQPLELKPEPELESLELELGLVPEPELSLDLEPLLKAGLDLGPELESVLESTLEPVIEPTLCMVSQTVPEPDQGPVSQPVPEPDLPCDLRHLNTEPMEIFRNCVKIEEIMPNGDPLLAGQNTVDEVYVSRPSHFYTDGPLMPSDF
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 44 (IMD44) [MIM:616636]: An autosomal recessive disorder characterized by increased susceptibility to viral infection, resulting in some patients in encephalopathy and infection-associated neurologic decompensation. {ECO:0000269|PubMed:23391734, ECO:0000269|PubMed:26122121}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Pseudo-TORCH syndrome 3 (PTORCH3) [MIM:618886]: An autosomal recessive disorder characterized by developmental delay with acute episodes of fever and multisystemic organ involvement, including coagulopathy, elevated liver enzymes, and proteinuria, often associated with thrombotic microangiopathy. Brain imaging shows progressive intracranial calcifications, white matter abnormalities, and sometimes cerebral or cerebellar atrophy. Disease onset is in the neonatal period, and death in early childhood is common. {ECO:0000269|PubMed:31836668, ECO:0000269|PubMed:32092142}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:23391734, PubMed:9020188). In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:23391734, PubMed:26122121, PubMed:9020188). {ECO:0000269|PubMed:23391734, ECO:0000269|PubMed:26122121, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:31836668, ECO:0000269|PubMed:32092142, ECO:0000269|PubMed:9020188}.
uniprot
proteins
mass_dalton
97916
uniprot
proteins
mutagenesis
MUTAGEN 374; /note="R->A: Prevents the nuclear import; when associated with A-375."; /evidence="ECO:0000269|PubMed:11150296"; MUTAGEN 375; /note="K->A: Prevents the nuclear import; when associated with A-374."; /evidence="ECO:0000269|PubMed:11150296"; MUTAGEN 409; /note="R->A: Prevents the nuclear import; when associated with A-415."; /evidence="ECO:0000269|PubMed:11150296"; MUTAGEN 415; /note="K->A: Prevents the nuclear import; when associated with A-409."; /evidence="ECO:0000269|PubMed:11150296"; MUTAGEN 690; /note="Y->F: Reduces phosphorylation of STAT1 in response to IFN-ALPHA."; /evidence="ECO:0000269|PubMed:7532278
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated in response to IFN-alpha. Phosphorylation at Ser-287 negatively regulates the transcriptional response. {ECO:0000269|PubMed:1638633, ECO:0000269|PubMed:23139419, ECO:0000269|PubMed:7532278, ECO:0000269|PubMed:9121453}.; PTM: 'Lys-48'-linked ubiquitination by DCST1 leads to STAT2 proteasomal degradation. {ECO:0000269|PubMed:27782195}.; PTM: (Microbial infection) Ubiquitinated by Herpes simplex virus 2 E3 ubiquitin ligase ICP22. {ECO:0000269|PubMed:32699158}.
uniprot
proteins
protein_family
Transcription factor STAT family
uniprot
proteins
pubmed
10702714
uniprot
proteins
pubmed
11150296
uniprot
proteins
pubmed
12509459
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1502204
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16227264
uniprot
proteins
pubmed
1638633
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
18579593
uniprot
proteins
pubmed
18701593
uniprot
proteins
pubmed
19007958
uniprot
proteins
pubmed
19279106
uniprot
proteins
pubmed
19754307
uniprot
proteins
pubmed
19812155
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21931555
uniprot
proteins
pubmed
23139419
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23391734
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25631085
uniprot
proteins
pubmed
26122121
uniprot
proteins
pubmed
27212660
uniprot
proteins
pubmed
27782195
uniprot
proteins
pubmed
27797853
uniprot
proteins
pubmed
28165510
uniprot
proteins
pubmed
29886262
uniprot
proteins
pubmed
30814285
uniprot
proteins
pubmed
31040183
uniprot
proteins
pubmed
31836668
uniprot
proteins
pubmed
32092142
uniprot
proteins
pubmed
32581091
uniprot
proteins
pubmed
32699158
uniprot
proteins
pubmed
34319780
uniprot
proteins
pubmed
7532278
uniprot
proteins
pubmed
7885841
uniprot
proteins
pubmed
8601453
uniprot
proteins
pubmed
9020188
uniprot
proteins
pubmed
9121453
uniprot
proteins
sequence_length
851
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11150296, ECO:0000269|PubMed:23139419, ECO:0000269|PubMed:27782195}. Nucleus {ECO:0000269|PubMed:11150296, ECO:0000269|PubMed:23139419}. Note=Translocated into the nucleus upon activation by IFN-alpha/beta. {ECO:0000269|PubMed:11150296, ECO:0000269|PubMed:23139419}.
uniprot
proteins