Ranbp10
entrez
74334
canonical
uniprot
Q6VN19
canonical
ensembl
ENSMUSG00000037415
resolver
ensp
ENSMUSP00000040045
resolver
ensp
ENSMUSP00000159340
resolver
enst
ENSMUST00000041400
resolver
enst
ENSMUST00000239468
resolver
genesymbol
Ranbp10
resolver
genesymbol_syn
Kiaa1464
resolver
uniprot
A0A0R4J0G4
resolver
uniprot
A9UGK3
resolver
uniprot
Q69ZJ1
resolver
uniprot
Q8C328
resolver
uniprot
Q8R1E6
resolver
uniprot_entry
A0A0R4J0G4_MOUSE
resolver
uniprot_entry
A9UGK3_MOUSE
resolver
uniprot_entry
RBP10_MOUSE
resolver
uniprot_sec
Q69ZJ1
resolver
uniprot_sec
Q8C328
resolver
uniprot_sec
Q8R1E6
resolver
amino_acid_sequence
MAAATADPGAGNPQAGDSSGGDSGGGLPSPGEQELSRRLQRLYPAVNQHETPLPRSWSPKDKYNYIGLSQGNLRVHYKGHGKNHKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINGTCFYTKNGHSLGIAFTDLPANLYPTVGLQTPGEIVDANFGQQPFLFDIEDYMREWRAKVQGTVHGFPISARLGEWQAVLQNMVSSYLVHHGYCSTATAFARMTETPIQEEQASIKNRQKIQKLVLEGRVGEAIETTQRFYPGLLEHNPNLLFMLKCRQFVEMVNGTDSEVRSLSSRSPKSQDSYPGSPSLSPRHGPSSSHIHNTGADSPSCSNGVASTKNKQNHSKYPAPSSSSSSSSSSSSSSPSSVNYSESNSTDSTKSQPHSSTSNQETSDSEMEMEAEHYPNGVLESVSTRIVNGAYKHDDLQTDESSMDDGHPRRQLCGGNQAATERIILFGRELQALSEQLGREYGKNLAHTEMLQDAFSLLAYSDPWSCPVGHQLDPIQREPVCAALNSAILESQNLPKQPPLMLALGQASECLRLMARAGLGSCSFARVDDYLH
uniprot
proteins
function
FUNCTION: May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (PubMed:18347012). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (PubMed:19801445). {ECO:0000250|UniProtKB:Q6VN20, ECO:0000269|PubMed:18347012, ECO:0000269|PubMed:19801445, ECO:0000305}.
uniprot
proteins
mass_dalton
67188
uniprot
proteins
mutagenesis
MUTAGEN 301; /note="L->I: Complete loss RAN-GEF activity. Partial loss of RAN-binding."; /evidence="ECO:0000269|PubMed:18347012
uniprot
proteins
protein_family
RANBP9/10 family
uniprot
proteins
pubmed
14684163
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18347012
uniprot
proteins
pubmed
19801445
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27622290
uniprot
proteins
sequence_length
620
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18347012}. Nucleus {ECO:0000269|PubMed:18347012}. Note=Predominantly cytoplasmic. Associates with cytoplasmic microtubules in mature megakaryocytes and platelets.
uniprot
proteins