MYO1F
entrez
4542
canonical
uniprot
O00160
canonical
ensembl
ENSG00000142347
resolver
ensp
ENSP00000494550
resolver
ensp
ENSP00000520697
resolver
ensp
ENSP00000547904
resolver
ensp
ENSP00000547905
resolver
ensp
ENSP00000547906
resolver
ensp
ENSP00000621107
resolver
enst
ENST00000644032
resolver
enst
ENST00000718254
resolver
genesymbol
MYO1F
resolver
hgnc
HGNC:7600
resolver
uniprot
Q8WWN7
resolver
uniprot_entry
MYO1F_HUMAN
resolver
uniprot_sec
Q8WWN7
resolver
amino_acid_sequence
MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESVDLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFLRMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKRERVDFADSVTKYDRRFKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFILQEDAADSFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRVKKEGWGGGGTRSVTFSRGFGDLAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSSQAPTRAAPAPPRGMDRNGVPPSARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARPPSEHNTEFLNVPDQGMAGMQRKRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDELSFNVNEVIEILMEDPSGWWKGRLHGQEGLFPGNYVEKI
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in MYO1F has been found in a patient with a form of non-syndromic sensorineural hearing loss. {ECO:0000269|PubMed:22938506}.
uniprot
proteins
function
FUNCTION: Molecular adapter required for the movement of immune cells, such as mast cells, neutrophils and T-cells, to sites of inflammation or infection (By similarity). Acts as a regulator of antifungal immunity in macrophages by acting as a molecular adapter between ATAT1 and alpha-tubulin, promoting alpha-tubulin acetylation and antifungal immune response (PubMed:34301894). Also acts as a positive regulator of cGAS-STING signaling by promoting plasma membrane localization of CGAS: following phosphorylation by SYK, acts as an molecular adapter by recruiting KAT2A to CGAS at the plasma membrane, leading to CGAS acetylation and activation (PubMed:39694035). {ECO:0000250|UniProtKB:P70248, ECO:0000269|PubMed:34301894, ECO:0000269|PubMed:39694035}.
uniprot
proteins
mass_dalton
124844
uniprot
proteins
mutagenesis
MUTAGEN 607; /note="Y->F: Strongly decreased phosphorylation by SYK; when associated with F-634."; /evidence="ECO:0000269|PubMed:39694035"; MUTAGEN 634; /note="Y->F: Strongly decreased phosphorylation by SYK; when associated with F-607."; /evidence="ECO:0000269|PubMed:39694035
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Tyr-607 and Tyr-634 by SYK at the plasma membrane, promoting recruitment of KAT2A and acetylation of CGAS. {ECO:0000269|PubMed:39694035}.
uniprot
proteins
protein_family
Myosin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
11804589
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
22938506
uniprot
proteins
pubmed
34301894
uniprot
proteins
pubmed
39694035
uniprot
proteins
pubmed
9119401
uniprot
proteins
sequence_length
1098
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:34301894}. Cell membrane {ECO:0000269|PubMed:39694035}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins