Hereditary nonpolyposis colorectal cancer
cv_term_accession
KW-0362
canonical
uniprot_keyword
KW-0362
canonical
name
Hereditary nonpolyposis colorectal cancer
uniprot
synonym
HNPCC
uniprot
synonym
Lynch's syndrome
uniprot
definition
Protein which, if defective, causes hereditary non-polyposis colorectal cancer (HNPCC), also known as Lynch's syndrome. It is an autosomal dominant syndrome which confers an increased risk for colorectal and endometrial cancers as well as others tumors. Clinically, HNPCC is often divided into two subgroups: type I, characterized by a hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon; type II, characterized by an increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
uniprot_keywords
uniprot
keywords