Q60870
uniprot
Q60870
canonical
amino_acid_sequence
MRERFDRFLHEKNCMTDLLAKLEAKTGVNRSFIALGVIGLVALYLVFGYGASLLCNLIGFGYPAYISMKAIESPNKDDDTQWLTYWVVYGVFSIAEFFSDLFLSWLPFYYMLKCGFLLWCMAPSPANGAEMLYRRIIRPIFLRHESQVDSVVKDVKDKAKETADAISKEVKKATVNLLGDVKKST
uniprot
proteins
function
FUNCTION: Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes. {ECO:0000269|PubMed:32075961}.
uniprot
proteins
mass_dalton
21051
uniprot
proteins
protein_family
DP1 family
uniprot
proteins
pubmed
19665976
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24668814
uniprot
proteins
pubmed
32075961
uniprot
proteins
pubmed
8647449
uniprot
proteins
sequence_length
185
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24668814}; Multi-pass membrane protein {ECO:0000255}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:32075961}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to endoplasmic reticulum tubular network (PubMed:24668814). In cardiomyocytes, localizes to the junctional sarcoplasmic reticulum membrane which is closely tethered to the cell membrane and contractile machinery (PubMed:32075961). {ECO:0000269|PubMed:24668814, ECO:0000269|PubMed:32075961}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..47; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q00765"; TRANSMEM 50..70; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q00765"; TRANSMEM 81..99; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q00765"; TRANSMEM 102..119; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q00765
uniprot
proteins