Gck
entrez
24385
canonical
uniprot
P17712
canonical
ensembl
ENSRNOG00000061527
resolver
ensembl
ENSRNOG00055030038
resolver
ensembl
ENSRNOG00060031866
resolver
ensembl
ENSRNOG00065020364
resolver
ensp
ENSRNOP00000068656
resolver
ensp
ENSRNOP00000069954
resolver
ensp
ENSRNOP00000071435
resolver
enst
ENSRNOT00000080147
resolver
genesymbol
Gck
resolver
uniprot
A0ACM8Q257
resolver
uniprot
A6IKR2
resolver
uniprot
P17711
resolver
uniprot
Q63219
resolver
uniprot
Q64596
resolver
uniprot
X2G6B3
resolver
uniprot_entry
A0ACM8Q257_RAT
resolver
uniprot_entry
A6IKR2_RAT
resolver
uniprot_entry
HXK4_RAT
resolver
uniprot_entry
X2G6B3_RAT
resolver
uniprot_sec
P17711
resolver
uniprot_sec
Q63219
resolver
uniprot_sec
Q64596
resolver
activity_regulation
ACTIVITY REGULATION: Subject to allosteric regulation (By similarity). Low glucose and high fructose-6-phosphate triggers association with the inhibitor GCKR followed by sequestration in the nucleus (PubMed:10456334). {ECO:0000250|UniProtKB:P35557, ECO:0000269|PubMed:10456334}.
uniprot
proteins
amino_acid_sequence
MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ
uniprot
proteins
ec_number
2.7.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively) (PubMed:12513690, PubMed:24187134, PubMed:6477520). Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (PubMed:6477520). Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues (By similarity). Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change its enzymatic activity within the physiological range of glucose concentrations, GCK acts as a glucose sensor in the pancreatic beta cell (By similarity). In pancreas, plays an important role in modulating insulin secretion (By similarity). In liver, helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (By similarity). Required to provide D-glucose 6-phosphate for the synthesis of glycogen (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:12513690, PubMed:6477520). {ECO:0000250|UniProtKB:P52792, ECO:0000269|PubMed:12513690, ECO:0000269|PubMed:24187134, ECO:0000269|PubMed:6477520}.
uniprot
proteins
mass_dalton
52116
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate metabolism; hexose metabolism. {ECO:0000305|PubMed:12513690, ECO:0000305|PubMed:6477520}.; PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4. {ECO:0000305|PubMed:12513690, ECO:0000305|PubMed:6477520}.
uniprot
proteins
protein_family
Hexokinase family
uniprot
proteins
pubmed
10456334
uniprot
proteins
pubmed
12513690
uniprot
proteins
pubmed
16542652
uniprot
proteins
pubmed
1999433
uniprot
proteins
pubmed
2396986
uniprot
proteins
pubmed
24187134
uniprot
proteins
pubmed
2550428
uniprot
proteins
pubmed
2590200
uniprot
proteins
pubmed
2662183
uniprot
proteins
pubmed
2909525
uniprot
proteins
pubmed
3515342
uniprot
proteins
pubmed
6477520
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10456334, ECO:0000269|PubMed:16542652}. Nucleus {ECO:0000269|PubMed:10456334}. Mitochondrion {ECO:0000269|PubMed:16542652}. Note=Under low glucose concentrations, associates with GCKR and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000269|PubMed:10456334}.
uniprot
proteins