NR1H2
entrez
7376
canonical
uniprot
P55055
canonical
ensembl
ENSG00000131408
resolver
ensp
ENSP00000253727
resolver
ensp
ENSP00000396151
resolver
genesymbol
NR1H2
resolver
genesymbol_syn
LXRB
resolver
genesymbol_syn
NER
resolver
genesymbol_syn
UNR
resolver
hgnc
HGNC:7965
resolver
uniprot
A8K490
resolver
uniprot
B4DNM6
resolver
uniprot
E7EWA6
resolver
uniprot
F1D8P7
resolver
uniprot
Q12970
resolver
uniprot
Q5I0Y1
resolver
uniprot_entry
F1D8P7_HUMAN
resolver
uniprot_entry
NR1H2_HUMAN
resolver
uniprot_sec
A8K490
resolver
uniprot_sec
B4DNM6
resolver
uniprot_sec
E7EWA6
resolver
uniprot_sec
Q12970
resolver
uniprot_sec
Q5I0Y1
resolver
amino_acid_sequence
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
uniprot
proteins
function
FUNCTION: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). {ECO:0000250|UniProtKB:Q60644, ECO:0000269|PubMed:20159957, ECO:0000269|PubMed:25661920}.
uniprot
proteins
mass_dalton
50974
uniprot
proteins
mutagenesis
MUTAGEN 409; /note="K->R: Impaired ability to act as an anti-inflammatory role during the hepatic acute phase response; when associated with R-447."; /evidence="ECO:0000269|PubMed:20159957"; MUTAGEN 447; /note="K->R: Impaired ability to act as an anti-inflammatory role during the hepatic acute phase response; when associated with R-409."; /evidence="ECO:0000269|PubMed:20159957
uniprot
proteins
post_translational_modification
PTM: Sumoylated by SUMO2 at Lys-409 and Lys-447 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation. {ECO:0000269|PubMed:20159957}.
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
12819202
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20159957
uniprot
proteins
pubmed
23931754
uniprot
proteins
pubmed
25661920
uniprot
proteins
pubmed
7926814
uniprot
proteins
sequence_length
460
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
uniprot
proteins