Rab4a
entrez
19341
canonical
uniprot
P56371
canonical
ensembl
ENSMUSG00000019478
resolver
ensp
ENSMUSP00000113401
resolver
ensp
ENSMUSP00000113886
resolver
enst
ENSMUST00000117702
resolver
enst
ENSMUST00000118535
resolver
genesymbol
Rab4a
resolver
genesymbol_syn
Rab4
resolver
uniprot
Q3TSQ6
resolver
uniprot
Q3ULK1
resolver
uniprot_entry
Q3ULK1_MOUSE
resolver
uniprot_entry
RAB4A_MOUSE
resolver
uniprot_sec
Q3TSQ6
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MAQTAMSETYDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGSKIINVGGKYVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNALTNWLTDARMLASQNIVLILCGNKKDLDADREVTFLEASRFAQENELMFLETSALTGENVEEAFMQCARKILNKIESGELDPERMGSGIQYGDAALRQLRSPRRTQAPSAQECGC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:14697203). RAB4A is involved in protein transport. Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (PubMed:14697203). {ECO:0000250|UniProtKB:P20338, ECO:0000269|PubMed:14697203}.
uniprot
proteins
mass_dalton
24409
uniprot
proteins
post_translational_modification
PTM: Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity. {ECO:0000269|PubMed:14697203}.; PTM: Phosphorylated by CDK1 kinase during mitosis. {ECO:0000250|UniProtKB:P20338}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11172003
uniprot
proteins
pubmed
14697203
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16923123
uniprot
proteins
pubmed
17509819
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20048159
uniprot
proteins
pubmed
20098723
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8950022
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P20338}; Peripheral membrane protein {ECO:0000250|UniProtKB:P20338}. Cytoplasm {ECO:0000250|UniProtKB:P20338}. Early endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Recycling endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1. {ECO:0000250|UniProtKB:P20338}.
uniprot
proteins