Tnpo2
entrez
212999
canonical
uniprot
Q99LG2
canonical
ensembl
ENSMUSG00000031691
resolver
ensp
ENSMUSP00000091051
resolver
ensp
ENSMUSP00000133076
resolver
ensp
ENSMUSP00000147583
resolver
ensp
ENSMUSP00000176211
resolver
ensp
ENSMUSP00000176212
resolver
ensp
ENSMUSP00000176214
resolver
ensp
ENSMUSP00000176218
resolver
ensp
ENSMUSP00000176219
resolver
ensp
ENSMUSP00000176222
resolver
enst
ENSMUST00000093360
resolver
enst
ENSMUST00000166592
resolver
enst
ENSMUST00000211601
resolver
genesymbol
Tnpo2
resolver
uniprot
E9PV58
resolver
uniprot
Q3U1S0
resolver
uniprot
Q8C0U9
resolver
uniprot_entry
E9PV58_MOUSE
resolver
uniprot_entry
Q3U1S0_MOUSE
resolver
uniprot_entry
TNPO2_MOUSE
resolver
uniprot_sec
Q8C0U9
resolver
amino_acid_sequence
MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLTHEAERPDSSEDAEDDDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFISVCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDAVASWVSPKDDLRDMFYKILHGFKDQVGEENWQQFSEQFPPLLKERLAAFYGV
uniprot
proteins
function
FUNCTION: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
100456
uniprot
proteins
protein_family
Importin beta family
uniprot
proteins
protein_family
Importin beta-2 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
887
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins