PPIP5K1
entrez
9677
canonical
uniprot
Q6PFW1
canonical
ensembl
ENSG00000168781
resolver
ensp
ENSP00000334779
resolver
ensp
ENSP00000353253
resolver
ensp
ENSP00000353446
resolver
ensp
ENSP00000371303
resolver
ensp
ENSP00000371309
resolver
ensp
ENSP00000380129
resolver
ensp
ENSP00000400887
resolver
ensp
ENSP00000516724
resolver
ensp
ENSP00000521840
resolver
ensp
ENSP00000521842
resolver
ensp
ENSP00000597190
resolver
ensp
ENSP00000597191
resolver
ensp
ENSP00000597192
resolver
ensp
ENSP00000597193
resolver
ensp
ENSP00000597195
resolver
ensp
ENSP00000635952
resolver
ensp
ENSP00000635953
resolver
ensp
ENSP00000635954
resolver
enst
ENST00000381885
resolver
enst
ENST00000420765
resolver
enst
ENST00000707073
resolver
enst
ENST00000851781
resolver
enst
ENST00000927133
resolver
enst
ENST00000965894
resolver
enst
ENST00000965895
resolver
genesymbol
PPIP5K1
resolver
genesymbol_syn
HISPPD2A
resolver
genesymbol_syn
IP6K
resolver
genesymbol_syn
IPS1
resolver
genesymbol_syn
KIAA0377
resolver
genesymbol_syn
VIP1
resolver
hgnc
HGNC:29023
resolver
uniprot
A0A8J8ZH50
resolver
uniprot
A0A9L9PYJ9
resolver
uniprot
B7WPL9
resolver
uniprot
O15082
resolver
uniprot
Q5HYF8
resolver
uniprot
Q7Z3A7
resolver
uniprot
Q86TE7
resolver
uniprot
Q86UV3
resolver
uniprot
Q86UV4
resolver
uniprot
Q86XW8
resolver
uniprot
Q8IZN0
resolver
uniprot_entry
A0A8J8ZH50_HUMAN
resolver
uniprot_entry
A0A9L9PYJ9_HUMAN
resolver
uniprot_entry
B7WPL9_HUMAN
resolver
uniprot_entry
VIP1_HUMAN
resolver
uniprot_sec
O15082
resolver
uniprot_sec
Q5HYF8
resolver
uniprot_sec
Q7Z3A7
resolver
uniprot_sec
Q86TE7
resolver
uniprot_sec
Q86UV3
resolver
uniprot_sec
Q86UV4
resolver
uniprot_sec
Q86XW8
resolver
uniprot_sec
Q8IZN0
resolver
amino_acid_sequence
MWSLTASEGESTTAHFFLGAGDEGLGTRGIGMRPEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPARPEECNLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEIRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVKHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPGGEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASNEGQDPQRETLAPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDGDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTRSTSLLNSMTIIQNPVKVCDQVFALIENLTHQIRERMQDPRSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKLEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLCYLRYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETQDAQWQRALDYLSAISELNYMTQIVIMLYEDNTQDPLSEERFHVELHFSPGVKGVEEEGSAPAGCGFRPASSENEEMKTNQGSMENLCPGKASDEPDRALQTSPQPPEGPGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARSHGKKLPPASLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLSRVCQRHTDAQAQASAALFDSMHSSQASDNPFSPPRTLHSPPLQLQQRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSQFGFSDQPSLNSHVAEEHQGLGLLQETPGSGAQELSIEGEQELFEPNQSPQVPPMETSQPYEEVSQPCQEVPDISQPCQDISEALSQPCQKVPDISQQCQENHDNGNHTCQEVPHISQPCQKSSQLCQKVSEEVCQLCLENSEEVSQPCQGVSVEVGKLVHKFHVGVGSLVQETLVEVGSPAEEIPEEVIQPYQEFSVEVGRLAQETSAINLLSQGIPEIDKPSQEFPEEIDLQAQEVPEEIN
uniprot
proteins
ec_number
2.7.4.24
uniprot
proteins
function
FUNCTION: Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}.
uniprot
proteins
mass_dalton
159521
uniprot
proteins
mutagenesis
MUTAGEN 399; /note="R->A: Decreases 8-fold the affinity for PtdIns(3,4,5)P3."; /evidence="ECO:0000269|PubMed:21222653"; MUTAGEN 417; /note="R->A: Decreases 16-fold the affinity for PtdIns(3,4,5)P3."; /evidence="ECO:0000269|PubMed:21222653
uniprot
proteins
protein_family
Histidine acid phosphatase family
uniprot
proteins
protein_family
VIP1 subfamily
uniprot
proteins
pubmed
12825070
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17690096
uniprot
proteins
pubmed
17702752
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18981179
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21222653
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9205841
uniprot
proteins
sequence_length
1433
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653}. Cell membrane {ECO:0000269|PubMed:21222653}. Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway. {ECO:0000269|PubMed:21222653}.
uniprot
proteins