Scd2
entrez
20250
canonical
uniprot
P13011
canonical
ensembl
ENSMUSG00000025203
resolver
ensp
ENSMUSP00000026221
resolver
enst
ENSMUST00000026221
resolver
genesymbol
Scd2
resolver
uniprot
Q8BH96
resolver
uniprot_entry
SCD2_MOUSE
resolver
uniprot_sec
Q8BH96
resolver
amino_acid_sequence
MPAHILQEISGAYSATTTITAPPSGGQQNGGEKFEKSSHHWGADVRPELKDDLYDPTYQDDEGPPPKLEYVWRNIILMALLHLGALYGITLVPSCKLYTCLFAYLYYVISALGITAGAHRLWSHRTYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFVLPTLVPWYCWGETFVNSLCVSTFLRYAVVLNATWLVNSAAHLYGYRPYDKNISSRENILVSMGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMALLGLAYDRKRVSRAAVLARIKRTGDGSCKSG
uniprot
proteins
ec_number
1.14.19.1
uniprot
proteins
function
FUNCTION: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:16443825). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:16443825). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:16443825). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides, especially during embryonic development and in neonates (PubMed:16118274). Important for normal permeability barrier function of the skin in neonates (PubMed:16118274). {ECO:0000269|PubMed:16118274, ECO:0000269|PubMed:16443825}.
uniprot
proteins
mass_dalton
40916
uniprot
proteins
protein_family
Fatty acid desaturase type 1 family
uniprot
proteins
pubmed
10545940
uniprot
proteins
pubmed
11161812
uniprot
proteins
pubmed
12815040
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16118274
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16443825
uniprot
proteins
pubmed
2570068
uniprot
proteins
sequence_length
358
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:16443825}; Multi-pass membrane protein {ECO:0000305|PubMed:16443825}. Microsome membrane {ECO:0000269|PubMed:16443825}.
uniprot
proteins
transmembrane_region
TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O00767"; TRANSMEM 97..117; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O00767"; TRANSMEM 217..236; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O00767"; TRANSMEM 241..262; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O00767
uniprot
proteins