Kremen2
entrez
73016
canonical
uniprot
Q8K1S7
canonical
ensembl
ENSMUSG00000040680
resolver
ensp
ENSMUSP00000046369
resolver
enst
ENSMUST00000046525
resolver
genesymbol
Kremen2
resolver
uniprot
Q0VBR6
resolver
uniprot_entry
KREM2_MOUSE
resolver
uniprot_sec
Q0VBR6
resolver
amino_acid_sequence
MGTPHLQGFLLLFPLLLRLHGASAGSLHSPGLSECFQVNGADYRGHQNYTGPRGAGRPCLFWDQTQQHSYSSASDPQGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPTCHMPGYLGCFVDSGAPPALSGPSGTSTKLTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDLARGRPAPATDCDQICFGHPGQLCGGDGRLGIYEVSVGSCQGNWSAPQGVIYSPDFPDEYGPDRNCSWVLGQLGAVLELTFRLFELADSRDRLELRDVSSGNLLRAFDGAHPPPPGPLRLRTAALLLTFRSDARGHAQGFALTYRGLQDTVEGRASPEDSTESLAGDPDGANASCSPKPGAAQASIGARVFSTVTAFSVLLLLLLSLLRLLRRRSCLLAPGKGSLAMGPSRGPGRSWAVWYRRPRGVALPCPPGDSQAEGPAAGYRPLSASSQSSLRSLVSAL
uniprot
proteins
function
FUNCTION: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6 (PubMed:12050670). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation (PubMed:18505822). {ECO:0000269|PubMed:12050670, ECO:0000269|PubMed:18505822}.
uniprot
proteins
mass_dalton
49170
uniprot
proteins
pubmed
12050670
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16531414
uniprot
proteins
pubmed
18505822
uniprot
proteins
pubmed
26206087
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 364..386; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins