Map3k21
entrez
234878
canonical
uniprot
Q8VDG6
canonical
ensembl
ENSMUSG00000031853
resolver
ensp
ENSMUSP00000034316
resolver
enst
ENSMUST00000034316
resolver
genesymbol
Map3k21
resolver
genesymbol_syn
Kiaa1804
resolver
genesymbol_syn
Mlk4
resolver
uniprot
Q5DTU6
resolver
uniprot
Q811F5
resolver
uniprot_entry
M3K21_MOUSE
resolver
uniprot_sec
Q5DTU6
resolver
uniprot_sec
Q811F5
resolver
activity_regulation
ACTIVITY REGULATION: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation. {ECO:0000250|UniProtKB:P80192}.
uniprot
proteins
amino_acid_sequence
MALPVAEGTADTPLSPARDDSGSTSSGMWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPASYVAPCGPVPPPAPPPPRPCSPVHVDFERLELKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAESVRREARLFAMLRHPNIIQLRGVCLRQPHLCLVLEFARGGALNRALAAAASDPRAPGPRRARRIPPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTRMSAAGTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQLTAIEEAVLTNMPQESFHSMQEDWKLEIQQMFSELRTKEKELRSREEELSRAALQQKSQELLLRRREQQLAEREIDVLERELNVLIFQLSQEAPHVKKRKGRFRRGRLRLKDGHRISLPSDFQHKITVQASPTLDKRRSSDSGLCSPPGSPLMLPRLRAIQLTSDENNKTRGRNMVFRQEDFEDVKRSFKKKGCTWGPSSVQTKERPEGRERVRPLSDGNSPWSSLLIKSQKTTPLASLFVDQPGSCEEQKLVPEGLEHRKPKQTKFPGQAHVGLPLCKDSQREDSSEAESREEGSPKGSPVNNVGAPMLRKKTESALCECGMLLASMALGLDVRKLHGAQAPAKPSPKMEKKEEGALQPASRCQSSPSSLLRQPSAGRAPSGGSTLLLPSAPSHSSKSSLSMKCLLQAGKEESSLGNARDLCGPTTLTPDPGSAAPESGCELIPGLRPKTDYGVLRSMPHAILEQTGERLPGCAIVGDKGCHHMQMGSEETPLWLQSAPEDSGLPHSPSPGPQRDLASQASLVKPEGVLGECQACPALPQRPHTASVRTTSPPTWVCDKDHQVPALACLLGAQERSRCQTPSLLDASIEGQKKDCAMPLCRVKSVMCQPSIYALEKDFLT
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
110112
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. {ECO:0000250|UniProtKB:P80192}.
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1002
uniprot
proteins