Krt15
entrez
287700
canonical
uniprot
Q6IFV3
canonical
ensembl
ENSRNOG00000071325
resolver
ensp
ENSRNOP00000098606
resolver
enst
ENSRNOT00000121062
resolver
genesymbol
Krt15
resolver
genesymbol_syn
Ka15
resolver
uniprot_entry
K1C15_RAT
resolver
amino_acid_sequence
MATTFLQTSSTFGSGSTRGGSLRVGGGSFGGGSLYGGGGSRSISASSARFVSSGAGVGFGGGMSCGFGGGFGGGFGGGFGDFGGGDGGLLSGNEKVTMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQKQSPASPDRDYSHYFKTMEEIRDKILAATIDNSRVILEIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRMLAEMREQYEAIAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTLQGLEIELQSQLSMKAGLENSLAEVECRYATQLQQIQGLITGLETQLSELRCEMEAQNQEYNMLLDIKTRLEQEISTYRNLLEGQDAKMAAIGVREASLRGGSSGGGSNFHISVEESVDGKVVSSRKRES
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in the epithelium. Forms heteropolymers with type II keratin KRT5, assembling into keratin intermediate filament network that promotes mechanical resilience of undifferentiated cells, including hair follicle bulge cells, foregut basal progenitors and intestinal crypt cells. Displays an antagonist role with KRT14 in basal epithelial cells, where KRT14 promotes cell differentiation while KRT15 maintains the progenitor state and promotes proliferation and clonogenicity (By similarity). Promotes the progenitor state in basal keratinocytes by maintaining cytoplasmic YAP1 less effectively than KRT14 due to missing biochemical motifs, thereby allowing higher YAP1 nuclear activity (By similarity). Also contributes to epithelial cell regeneration after injury. In the absence of KRT14, forms a bona fide, but ultrastructurally distinct keratin filament network with KRT5 (By similarity). {ECO:0000250|UniProtKB:P19012, ECO:0000250|UniProtKB:Q61414}.
uniprot
proteins
mass_dalton
48870
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15085952
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641100
uniprot
proteins
sequence_length
447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q61414}.
uniprot
proteins