RNF157
entrez
114804
canonical
uniprot
Q96PX1
canonical
ensembl
ENSG00000141576
resolver
ensp
ENSP00000269391
resolver
ensp
ENSP00000321837
resolver
ensp
ENSP00000497353
resolver
ensp
ENSP00000735093
resolver
ensp
ENSP00000735094
resolver
enst
ENST00000647930
resolver
genesymbol
RNF157
resolver
genesymbol_syn
KIAA1917
resolver
hgnc
HGNC:29402
resolver
uniprot
A0A3B3ISM3
resolver
uniprot
Q8NB72
resolver
uniprot
Q96N56
resolver
uniprot_entry
A0A3B3ISM3_HUMAN
resolver
uniprot_entry
RN157_HUMAN
resolver
uniprot_sec
Q8NB72
resolver
uniprot_sec
Q96N56
resolver
amino_acid_sequence
MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKFDSTHPEGYLFGENSDLNFLGNRPVVFPYAAPPPQEPVKTLRSLVNIRKDTLRLVKCAEEVKSPGEEASKAKVHYNVEFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSETVQYKRGVCQQFCLPSHTVDPSEWAEEELGFDLDREVYPLVVHAVVDEGDEYFGHCHVLLGTFEKHTDGTFCVKPLKQKQVVDGVSYLLQEIYGIENKYNTQDSKVAEDEVSDNSAECVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSGMLPSYGSDGHLPPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEEDGSPTQEGQRTCAFLGMECDNNNDFDIASVKALDNKLCSEVCLPGAWQADDNAVSRNAQRRRLSSSSLEDSETRPCVWGPLAV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764). {ECO:0000269|PubMed:25342469, ECO:0000269|PubMed:28655764}.
uniprot
proteins
mass_dalton
73579
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-660, Ser-661, Ser-662 and Ser-663 downstream of the PI3K and MAPK pathways influences the E3 ligase activity and stability of RNF157 during the cell cycle in an anaphase-promoting complex/cyclosome-CDH1-dependent manner (PubMed:28655764). {ECO:0000269|PubMed:28655764}.
uniprot
proteins
pubmed
11572484
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
20213681
uniprot
proteins
pubmed
25342469
uniprot
proteins
pubmed
28655764
uniprot
proteins
sequence_length
679
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:M0R5D6}.
uniprot
proteins