Mbnl1
entrez
282635
canonical
uniprot
A0A8I6B1J2
canonical
ensembl
ENSRNOG00000014076
resolver
ensembl
ENSRNOG00055018550
resolver
ensembl
ENSRNOG00060005260
resolver
ensembl
ENSRNOG00065025925
resolver
ensp
ENSRNOP00000033304
resolver
ensp
ENSRNOP00000076663
resolver
ensp
ENSRNOP00000081828
resolver
ensp
ENSRNOP00000094816
resolver
ensp
ENSRNOP00000095306
resolver
ensp
ENSRNOP00000100802
resolver
ensp
ENSRNOP00000106207
resolver
ensp
ENSRNOP00055025572
resolver
ensp
ENSRNOP00060006702
resolver
ensp
ENSRNOP00065036788
resolver
enst
ENSRNOT00000036808
resolver
enst
ENSRNOT00000102621
resolver
enst
ENSRNOT00000106022
resolver
enst
ENSRNOT00000111474
resolver
enst
ENSRNOT00000168888
resolver
enst
ENSRNOT00055031640
resolver
enst
ENSRNOT00060008879
resolver
enst
ENSRNOT00065044896
resolver
genesymbol
Mbnl1
resolver
uniprot
A0A8I5Y4V0
resolver
uniprot
A0A8I5ZVU8
resolver
uniprot
A0A8I6AQ03
resolver
uniprot
A0ABK0LR71
resolver
uniprot
F1M9N4
resolver
uniprot_entry
A0A8I5Y4V0_RAT
resolver
uniprot_entry
A0A8I5ZVU8_RAT
resolver
uniprot_entry
A0A8I6AQ03_RAT
resolver
uniprot_entry
A0ABK0LR71_RAT
resolver
uniprot_entry
F1M9N4_RAT
resolver
uniprot_entry
MBNL1_RAT
resolver
amino_acid_sequence
MAVSVTPIRDTKWLTLEVCREFQRGTCSRPDTECKFAHPSKSCQVENGRVIACFDSLKGRCSRENCKYLHPPPHLKTQLEINGRNNLIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATNASAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKLMRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATAAAMTQSAVKSLKRPLEATFDLGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPVPMVHGATPATVSAATTSATSVPFAATATANQIPIISAEHLTSHKYVTQM
uniprot
proteins
function
FUNCTION: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA (By similarity). Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues (By similarity). Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events (PubMed:37548402). Regulates NCOR2 alternative splicing (PubMed:31283468). {ECO:0000250|UniProtKB:Q9NR56, ECO:0000269|PubMed:31283468, ECO:0000269|PubMed:37548402}.
uniprot
proteins
mass_dalton
41746
uniprot
proteins
protein_family
Muscleblind family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
31283468
uniprot
proteins
pubmed
37548402
uniprot
proteins
sequence_length
387
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NR56}. Cytoplasm {ECO:0000250|UniProtKB:Q9NR56}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q9NR56}.
uniprot
proteins