Cd300lf
entrez
287818
canonical
uniprot
Q566E6
canonical
ensembl
ENSRNOG00000021424
resolver
ensembl
ENSRNOG00065021515
resolver
ensp
ENSRNOP00000033887
resolver
ensp
ENSRNOP00065029486
resolver
enst
ENSRNOT00000039284
resolver
enst
ENSRNOT00065036635
resolver
genesymbol
Cd300lf
resolver
genesymbol_syn
Cd300f
resolver
genesymbol_syn
Clm1
resolver
uniprot
A0A0H2UHU2
resolver
uniprot
D0V9T5
resolver
uniprot_entry
A0A0H2UHU2_RAT
resolver
uniprot_entry
CLM1_RAT
resolver
uniprot_entry
D0V9T5_RAT
resolver
amino_acid_sequence
MHLSLLALFLFWISGCFTAQDPVTGPEEVSGYEQGSLTVWCRYGSWWKDYSKYWCRGPKRSSCEIRVETDASERLVKENHVSIRDDQTNFTFTVTMEDLRMSDAGIYWCGITKAGYDHMFKVHVSINPVPTTPTTTSTTTIFTVTTTVKETSTLSTQTSHYSDNRYDSGGVGDGNGFLDLSVLLPVISAALLLLLLVVSLIAWRMVRRQKKAAGPPSGQADSVTHILCPPKPHVQPLEDDLCYANLSLQQPRTSPLKKGSSMSSSGKDHQEEVEYVTMAPFPREEISYAALSLASLGQEPTYSNTACLVTHGPRTNLGEETTEYSSIRRPMP
uniprot
proteins
function
FUNCTION: Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement. {ECO:0000250|UniProtKB:Q6SJQ7, ECO:0000250|UniProtKB:Q8TDQ1}.
uniprot
proteins
mass_dalton
36823
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine. {ECO:0000250|UniProtKB:Q6SJQ7}.
uniprot
proteins
protein_family
CD300 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
332
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 182..202; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins