Dgkh
entrez
380921
canonical
uniprot
D3YXJ0
canonical
ensembl
ENSMUSG00000034731
resolver
ensp
ENSMUSP00000154031
resolver
ensp
ENSMUSP00000154036
resolver
ensp
ENSMUSP00000154554
resolver
ensp
ENSMUSP00000207607
resolver
enst
ENSMUST00000226342
resolver
enst
ENSMUST00000227767
resolver
enst
ENSMUST00000228362
resolver
genesymbol
Dgkh
resolver
uniprot
A0A0B5JC35
resolver
uniprot
A0A2I3BQ43
resolver
uniprot
A0A2I3BQ48
resolver
uniprot
A0A2I3BRD7
resolver
uniprot
A0JP53
resolver
uniprot_entry
A0A2I3BQ43_MOUSE
resolver
uniprot_entry
A0A2I3BQ48_MOUSE
resolver
uniprot_entry
A0A2I3BRD7_MOUSE
resolver
uniprot_entry
A0JP53_MOUSE
resolver
uniprot_entry
DGKH_MOUSE
resolver
uniprot_sec
A0A0B5JC35
resolver
amino_acid_sequence
MAGAGSQHHPQGVAGGAVAGASAVSPTAAGPGEDSSDSEAEQEGPQKLIRKVSTSGQMRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNANNSFTIITPFRRLMLCAENRKEMEVWISSLKSVQSREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDVYHPVCPLGQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPYLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLHKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPAKSSLLPEPVAATEEFYMTIYEDSVANHLTKIVNSDEHAVVISSAKILCETVKDFVAKVEKAQDRTLENTVVAEAVASKCSVLNEKLEQLLQALHADSQASRVPPGIGPAIPEEDTVESASDESLGESKDQLVNDIGKPSSQKAVKPREIMLRANSLKKAVRQVIEEAEKVMDEPAVQPSEPVSPSCDYDTETDEAKEDDAKESLSAKTTSQSPDAQASCGHPQTDSVAGPAMATTKENLPVLNTRIICPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSLDGYSEKCVMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAVFDSVQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWEDKQKCDSGKPVLRTNLYIHPAPDLATEEVSQMRLCSQAAEELITRICDAATIHCLLEQELAHAVNACSHALNKANPRFPESLTRDTATEIAINVKALYNETEALLVGRVPLHLESPHEERVSSALHSVEMELQKLTEIPWLYYILRPSEDEEPPLDCTKRNNKSTVFRIVPKFKKEKAQKQKTSSQPVQNWGTEEVAAWLDLLNLGEYKEIFIRHDVRGAELLHLERRDLKDLGIPKVGHMKRILQGIKELERNPPNLV
uniprot
proteins
ec_number
2.7.1.107
uniprot
proteins
function
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:27643686). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (By similarity). {ECO:0000250|UniProtKB:Q86XP1, ECO:0000269|PubMed:27643686, ECO:0000305}.
uniprot
proteins
mass_dalton
134132
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000305|PubMed:27643686}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation does not inhibit catalytic activity. {ECO:0000250|UniProtKB:Q86XP1}.
uniprot
proteins
protein_family
Eukaryotic diacylglycerol kinase family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25613821
uniprot
proteins
pubmed
27643686
uniprot
proteins
sequence_length
1211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27643686}. Cell membrane {ECO:0000269|PubMed:27643686}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:27643686}. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli. Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association. Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS. {ECO:0000250|UniProtKB:Q86XP1}.
uniprot
proteins