Cyp7b1
entrez
13123
canonical
uniprot
Q60991
canonical
ensembl
ENSMUSG00000039519
resolver
ensp
ENSMUSP00000037487
resolver
ensp
ENSMUSP00000216525
resolver
enst
ENSMUST00000035625
resolver
genesymbol
Cyp7b1
resolver
uniprot
Q3USU4
resolver
uniprot
Q9CZ39
resolver
uniprot_entry
CP7B1_MOUSE
resolver
uniprot_entry
Q3USU4_MOUSE
resolver
uniprot_sec
Q9CZ39
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by drugs voriconazole and metyrapone. {ECO:0000250|UniProtKB:O75881}.
uniprot
proteins
amino_acid_sequence
MQGATTLDAASPGPLALLGLLFAATLLLSALFLLTRRTRRPREPPLIKGWLPYLGMALKFFKDPLTFLKTLQRQHGDTFTVFLVGKYITFVLNPFQYQYVTKNPKQLSFQKFSSRLSAKAFSVKKLLTDDDLNEDVHRAYLLLQGKPLDALLETMIQEVKELFESQLLKITDWNTERIFAFCGSLVFEITFATLYGKILAGNKKQIISELRDDFFKFDDMFPYLVSDIPIQLLRNEESMQKKIIKCLTSEKVAQMQGQSKIVQERQDLLKRYYRHDDPEIGAHHLGFLWASLANTIPAMFWAMYYILRHPEAMEALRDEIDSFLQSTGQKKGPGISVHFTREQLDSLVCLESTILEVLRLCSYSSIIREVQEDMNLSLESKSFSLRKGDFVALFPPLIHNDPEIFDAPKEFRFDRFIEDGKKKSTFFKGGKKLKTYVMPFGLGTSKCPGRYFAVNEMKLLLIMLLTYFDLEIIDRKPIGLNHSRMFLGIQHPDSAVSFRYKAKSWRS
uniprot
proteins
ec_number
1.14.14.26
uniprot
proteins
ec_number
1.14.14.29
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids (PubMed:10748047, PubMed:11067870, PubMed:9144166, PubMed:9295351). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of steroids with a preference for 7-alpha position. Usually metabolizes steroids carrying a hydroxy group at position 3, functioning as a 3-hydroxy steroid 7-alpha hydroxylase (PubMed:10748047, PubMed:11067870, PubMed:9144166, PubMed:9295351). Hydroxylates oxysterols, including 25-hydroxycholesterol and (25R)-cholest-5-ene-3beta,26-diol toward 7-alpha hydroxy derivatives, which may be transported to the liver and converted to bile acids (PubMed:10748047, PubMed:11067870, PubMed:9144166, PubMed:9295351). Via its product 7-alpha,25-dihydroxycholesterol, a ligand for the chemotactic G protein-coupled receptor GPR183/EBI2, regulates B cell migration in germinal centers of lymphoid organs, thus guiding efficient maturation of plasma B cells and overall antigen-specific humoral immune response (PubMed:22999953). 7-alpha hydroxylates neurosteroids, including 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone) and pregnenolone, both involved in hippocampus-associated memory and learning (PubMed:9144166). Metabolizes androstanoids toward 6- or 7-alpha hydroxy derivatives (By similarity). {ECO:0000250|UniProtKB:O75881, ECO:0000269|PubMed:10748047, ECO:0000269|PubMed:11067870, ECO:0000269|PubMed:22999953, ECO:0000269|PubMed:9144166, ECO:0000269|PubMed:9295351}.
uniprot
proteins
mass_dalton
58470
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; bile acid biosynthesis. {ECO:0000269|PubMed:10748047, ECO:0000269|PubMed:11067870, ECO:0000269|PubMed:9144166, ECO:0000269|PubMed:9295351}.; PATHWAY: Steroid hormone biosynthesis. {ECO:0000269|PubMed:9144166}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10748047
uniprot
proteins
pubmed
11067870
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22999953
uniprot
proteins
pubmed
8530364
uniprot
proteins
pubmed
9144166
uniprot
proteins
pubmed
9295351
uniprot
proteins
sequence_length
507
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O75881}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000250|UniProtKB:O75881}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..34; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 178..198; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 287..307; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins