NAMPT
entrez
10135
canonical
uniprot
P43490
canonical
ensembl
ENSG00000105835
resolver
ensp
ENSP00000222553
resolver
ensp
ENSP00000390591
resolver
ensp
ENSP00000505390
resolver
ensp
ENSP00000506129
resolver
ensp
ENSP00000506540
resolver
ensp
ENSP00000571945
resolver
ensp
ENSP00000571946
resolver
ensp
ENSP00000591456
resolver
enst
ENST00000222553
resolver
enst
ENST00000424768
resolver
enst
ENST00000681255
resolver
enst
ENST00000681391
resolver
enst
ENST00000681491
resolver
enst
ENST00000901886
resolver
enst
ENST00000901887
resolver
enst
ENST00000921397
resolver
genesymbol
NAMPT
resolver
genesymbol_syn
PBEF
resolver
genesymbol_syn
PBEF1
resolver
hgnc
HGNC:30092
resolver
uniprot
A0A7P0T941
resolver
uniprot
A4D0Q9
resolver
uniprot
A4D0R0
resolver
uniprot
Q3KQV0
resolver
uniprot
Q8WW95
resolver
uniprot_entry
A0A7P0T941_HUMAN
resolver
uniprot_entry
NAMPT_HUMAN
resolver
uniprot_sec
A4D0Q9
resolver
uniprot_sec
A4D0R0
resolver
uniprot_sec
Q3KQV0
resolver
uniprot_sec
Q8WW95
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by FK866. FK866 competes for the same binding site as nicotinamide, but due to its very low dissociation rate, it is essentially an irreversible inhibitor. {ECO:0000269|PubMed:16783377}.
uniprot
proteins
amino_acid_sequence
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
uniprot
proteins
ec_number
2.4.2.12
uniprot
proteins
function
FUNCTION: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}.
uniprot
proteins
mass_dalton
55521
uniprot
proteins
mutagenesis
MUTAGEN 219; /note="D->N,S: No effect on activity towards nicotinamide. Alters specificity, so that the enzyme acquires activity towards nicotinic acid."; /evidence="ECO:0000269|PubMed:16783377"; MUTAGEN 247; /note="H->A: Reduces activity towards nicotinamide."; /evidence="ECO:0000269|PubMed:16783377"; MUTAGEN 311; /note="R->D: Reduces activity towards nicotinamide."; /evidence="ECO:0000269|PubMed:16783377
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.
uniprot
proteins
protein_family
NAPRTase family
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16783377
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21741723
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22462624
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24130902
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8289818
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24130902}. Cytoplasm {ECO:0000250|UniProtKB:Q99KQ4}. Secreted {ECO:0000269|PubMed:21741723}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000269|PubMed:21741723, ECO:0000269|PubMed:24130902}.
uniprot
proteins