Mgst2
entrez
211666
canonical
uniprot
A2RST1
canonical
ensembl
ENSMUSG00000074604
resolver
ensp
ENSMUSP00000096705
resolver
ensp
ENSMUSP00000141745
resolver
ensp
ENSMUSP00000355475
resolver
enst
ENSMUST00000099106
resolver
enst
ENSMUST00000159554
resolver
genesymbol
Mgst2
resolver
genesymbol_syn
Gst2
resolver
uniprot
A0A0A6YWX7
resolver
uniprot_entry
A0A0A6YWX7_MOUSE
resolver
uniprot_entry
MGST2_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Each monomer binds on GSH molecule but only one subunit is catalytically active. {ECO:0000250|UniProtKB:Q99735}.
uniprot
proteins
amino_acid_sequence
MAGDSSLLAAVSLLSACQQSYFAWRVGRARLKHKIAPPAVTGPLEFERIFRAQQNSLEFYPVFIVMLWMAGWYFNQVFAACLGLLYIYARHKYFWGYAEAAEKRITGFRLSLGILTLLPVLAVLGVASRFLNEYLDFHVAKKLRKPF
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
ec_number
2.5.1.18
uniprot
proteins
ec_number
4.4.1.20
uniprot
proteins
function
FUNCTION: Catalyzes several different glutathione-dependent reactions. Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE. Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB). Also catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (By similarity). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed:26656251). {ECO:0000250|UniProtKB:Q99735, ECO:0000269|PubMed:26656251}.
uniprot
proteins
mass_dalton
16786
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26656251
uniprot
proteins
sequence_length
147
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q99735}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:Q99735}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 107..127; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins