RAB15
entrez
376267
canonical
uniprot
P59190
canonical
ensembl
ENSG00000139998
resolver
ensp
ENSP00000267512
resolver
ensp
ENSP00000434103
resolver
ensp
ENSP00000452195
resolver
ensp
ENSP00000496006
resolver
enst
ENST00000554593
resolver
enst
ENST00000646728
resolver
genesymbol
RAB15
resolver
hgnc
HGNC:20150
resolver
uniprot
A0A2R8Y7G7
resolver
uniprot
G3V562
resolver
uniprot
G5EMR7
resolver
uniprot
G5EMR8
resolver
uniprot
Q86TX7
resolver
uniprot
Q8IW89
resolver
uniprot_entry
A0A2R8Y7G7_HUMAN
resolver
uniprot_entry
G3V562_HUMAN
resolver
uniprot_entry
G5EMR8_HUMAN
resolver
uniprot_entry
RAB15_HUMAN
resolver
uniprot_sec
G5EMR7
resolver
uniprot_sec
Q86TX7
resolver
uniprot_sec
Q8IW89
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MAKQYDVLFRLLLIGDSGVGKTCLLCRFTDNEFHSSHISTIGVDFKMKTIEVDGIKVRIQIWDTAGQERYQTITKQYYRRAQGIFLVYDISSERSYQHIMKWVSDVDEYAPEGVQKILIGNKADEEQKRQVGREQGQQLAKEYGMDFYETSACTNLNIKESFTRLTELVLQAHRKELEGLRMRASNELALAELEEEEGKPEGPANSSKTCWC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB15 may act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal (By similarity). {ECO:0000250|UniProtKB:P35289, ECO:0000250|UniProtKB:P61026}.
uniprot
proteins
mass_dalton
24391
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16195351
uniprot
proteins
pubmed
27552051
uniprot
proteins
pubmed
35871249
uniprot
proteins
sequence_length
212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
uniprot
proteins