Atp6v1c1
entrez
299971
canonical
uniprot
Q5FVI6
canonical
ensembl
ENSRNOG00000004846
resolver
ensembl
ENSRNOG00055023757
resolver
ensembl
ENSRNOG00060007035
resolver
ensembl
ENSRNOG00065003837
resolver
ensp
ENSRNOP00000006917
resolver
ensp
ENSRNOP00000085031
resolver
ensp
ENSRNOP00055033149
resolver
ensp
ENSRNOP00060008697
resolver
ensp
ENSRNOP00065004075
resolver
enst
ENSRNOT00000006917
resolver
enst
ENSRNOT00000104331
resolver
enst
ENSRNOT00055040811
resolver
enst
ENSRNOT00060011579
resolver
enst
ENSRNOT00065005624
resolver
genesymbol
Atp6v1c1
resolver
uniprot
A0A8I6GCD8
resolver
uniprot_entry
A0A8I6GCD8_RAT
resolver
uniprot_entry
VATC1_RAT
resolver
amino_acid_sequence
MTEFWLISAPGEKTCQQTWEKLHAATTKNNNLAVSSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLASGVDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVTQIDNDLKSRASAYNNLKGNLQNLERKNAGSLLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDWIKQYETLAEMVVPRSSNVLSEDQDSYLCNVTLFKKAVDDFRHKARENKFIVRDFQYNEEEMRADKEEMNRLSTDKKKQFGPLVRWLKVNFSEAFIAWIHIKALRVFVESVLRYGLPVNFQAMLLQPNKKSVKKLREVLHELYKHLDSSAAAIIDAPMDIPGLNLSQQEYYPYVYYKIDCNLLEFK
uniprot
proteins
function
FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32165585). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32165585). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). {ECO:0000250|UniProtKB:P21283, ECO:0000250|UniProtKB:P31412, ECO:0000269|PubMed:32165585}.
uniprot
proteins
mass_dalton
43901
uniprot
proteins
protein_family
V-ATPase C subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
32165585
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:32165585}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:32165585}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins