Trim36
entrez
28105
canonical
uniprot
Q80WG7
canonical
ensembl
ENSMUSG00000033949
resolver
ensp
ENSMUSP00000037978
resolver
ensp
ENSMUSP00000129771
resolver
enst
ENSMUST00000037011
resolver
enst
ENSMUST00000167364
resolver
genesymbol
Trim36
resolver
uniprot
E9Q3A0
resolver
uniprot
Q7TNM1
resolver
uniprot_entry
E9Q3A0_MOUSE
resolver
uniprot_entry
TRI36_MOUSE
resolver
uniprot_sec
Q7TNM1
resolver
amino_acid_sequence
MSESEEISEFGYIMELLAKGKVTIKNIEKELICPACKELFTHPLILPCQHSVCHKCVKELLLSLDDSFNDVASDSSNQSSPRLRLTSPSMDKIDKINRPGWKRNSLTPRPTTFPCPGCEHDVDLGERGVSGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCNECFKIYHPWGTVKAQHEYVGPTTNFRPKVLMCPEHETERINMYCELCRRPVCHLCKLGGNHSNHRVTTMSSAYKTLKEKLSKDIDFLIGKESQVKSQISELNLLMKETECNGERAKEEALAHFEKLFEILEDRKSSVLKAIDASKKLRLDKFHTQMEEYQGLLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQASFEDYVVNISKQTEVLGELSFFSSGIDIPEINEEQSKVYNNALIDWHHPEKDKADSYVLEYRKINRDEEMISWNEIEVHGTSKVVSNLESNSPYAFRVRAYRGSICSPCSRELILHTPPAPVFSFLFDEKCGYNTEHLLLNLKRDRVESRAGFNVLLAAERIQVGHYTSLDYIIGDVGVTKGKHFWACRVEPYSYLVKVGVASSDKLQEWLRSPRDAASPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMKKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVSFYDMDHMKCLYERQVDCSHTMYPAFALMGSGGIQLEEAITAKYLEYEEDV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins including CTNNB1, FOXA2 and AKT1 (PubMed:19232519). Involved in chromosome segregation and cell cycle regulation (PubMed:12917430). May play a role in the acrosome reaction and fertilization. Inhibits lung fibroblast proliferation, migration, and differentiation. Mechanistically, mediates 'Lys-48'-linked polyubiquitination of phospho-AKT1, leading to its proteasomal degradation and consequent inhibition of AKT signaling. Promotes apoptosis via inhibition of the Wnt/beta-catenin signaling pathway. Regulates ferroptosis by ubiquitinating and degrading FOXA2 (By similarity). {ECO:0000250|UniProtKB:Q9NQ86, ECO:0000269|PubMed:12917430, ECO:0000269|PubMed:19232519}.
uniprot
proteins
mass_dalton
82791
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
12917430
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16434393
uniprot
proteins
pubmed
19232519
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28087737
uniprot
proteins
sequence_length
729
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NQ86}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:12917430}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19232519}. Note=Found in the acrosomal region of elongated spermatids and mature sperm (PubMed:12917430). Colocalizes with alpha-tubulin (PubMed:19232519). {ECO:0000269|PubMed:12917430, ECO:0000269|PubMed:19232519}.
uniprot
proteins