Gprc6a
entrez
210198
canonical
uniprot
Q8K4Z6
canonical
ensembl
ENSMUSG00000019905
resolver
ensp
ENSMUSP00000020062
resolver
genesymbol
Gprc6a
resolver
uniprot
Q5DK51
resolver
uniprot
Q5DK52
resolver
uniprot_entry
GPC6A_MOUSE
resolver
uniprot_sec
Q5DK51
resolver
uniprot_sec
Q5DK52
resolver
amino_acid_sequence
MALLITVVTCFMIILDTSQSCHTPDDFVAITSPGHIMIGGLFAIHEKMLSSDDHPRRPQIQKCAGFEISVFLQTLAMIHSIEMINNSTLLSGVKLGYEIYDTCTEVTAAMAATLRFLSKFNCSRETVVFQCDYSSYMPRVKAVIGAGYSETSIAVSRMLNLQLMPQVSYESTAEILSDKIRFPSFLRTVPSDFYQTKAMAHLIRQSGWNWIGAITTDDDYGRLALNTFAIQAAENNVCIAFKEVLPAFLSDNTIEVRINQTLEKIIAEAQVNVIVVFLRKFHVFNLFTKAIERKISKIWIASDNWSTATKIITIPNVKKLGKVVGFAFRRGNTSSFHSFLQTLHMYPNDNNKPLHEFAMLVSACKYIKDGDLSQCISNYSQATLTYDTTKTIENHLFKRNDFLWHYTEPGLIYSIQLAVFALGHAIRDLCQARDCKKPNAFQPWELLAVLKNVTFTDGRNSFHFDAHGDLNTGYDVVLWKETNGLMTVTKMAEYDLQRDVFITTNQETKHEFRKLKQILSKCSKECSPGQMKKATGSQHSCCYECVSCPENHYSNETDMDHCLLCNNETHWAPVRSTTCFEKEVEYLDWDDSLALLLIALSLLGIAFVLAIGIIFTRNLKTPVVKSSGGLVVCYVMLICHALNFASTGFFIGEPQDFACKTRQTLFGVSFTLCVSCILTKSLKILLAFSFDPKLTMFLKCLYRPVPIVLTCTGIQVVICTLWLVLAAPSVEENISLPRVIILECEEGSALAFGTMLGYITVLAFICFVFAFKGRKLPENYNEAKFLTFGMLIYFIAWITFIPVYTTTFGKYLPAVEIIVILISNYGILCCIFFPKCYIILCKQKTNTKSAFLQMVYNYSAHSVDSLALSHVSLDSTSYDTATTNQSPGNKMTACQNDNHLPAQVLPHTGTAKTIKASKTLRQKRSSSI
uniprot
proteins
function
FUNCTION: Receptor activated by multiple ligands, including osteocalcin (BGLAP), basic amino acids, and various cations (PubMed:15576628, PubMed:16199532, PubMed:21333348). Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids (PubMed:15576628). The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+) (PubMed:16199532). Seems to act through a G(q)/G(11) and G(i)-coupled pathway (PubMed:15576628, PubMed:16199532). Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (PubMed:21333348). Mediates the non-genomic effects of androgens in multiple tissue (PubMed:19050760). May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (PubMed:19050760, PubMed:20947496). {ECO:0000269|PubMed:15576628, ECO:0000269|PubMed:16199532, ECO:0000269|PubMed:19050760, ECO:0000269|PubMed:20947496, ECO:0000269|PubMed:21333348}.
uniprot
proteins
mass_dalton
104213
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:15816861}.
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15576628
uniprot
proteins
pubmed
15816861
uniprot
proteins
pubmed
16199532
uniprot
proteins
pubmed
19050760
uniprot
proteins
pubmed
20947496
uniprot
proteins
pubmed
21333348
uniprot
proteins
sequence_length
928
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15816861}; Multi-pass membrane protein {ECO:0000269|PubMed:15816861}.
uniprot
proteins
transmembrane_region
TRANSMEM 595..615; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 631..651; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 670..690; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 707..727; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 751..771; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 785..805; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 813..833; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins