CYP2E1
entrez
1571
canonical
uniprot
P05181
canonical
ensembl
ENSG00000130649
resolver
ensp
ENSP00000252945
resolver
ensp
ENSP00000440689
resolver
enst
ENST00000252945
resolver
enst
ENST00000463117
resolver
genesymbol
CYP2E1
resolver
genesymbol_syn
CYP2E
resolver
hgnc
HGNC:2631
resolver
uniprot
Q5VZD5
resolver
uniprot
Q6NWT9
resolver
uniprot
Q9UK47
resolver
uniprot_entry
CP2E1_HUMAN
resolver
uniprot_sec
Q5VZD5
resolver
uniprot_sec
Q6NWT9
resolver
uniprot_sec
Q9UK47
resolver
activity_regulation
ACTIVITY REGULATION: The omega-1 hydroxylase activity is stimulated by cytochrome b5. {ECO:0000269|PubMed:10553002}.
uniprot
proteins
amino_acid_sequence
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS
uniprot
proteins
ec_number
1.14.13.n7
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable). {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:18577768, ECO:0000305|PubMed:9348445}.
uniprot
proteins
mass_dalton
56849
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:18577768}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10553002
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15469410
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18577768
uniprot
proteins
pubmed
18818195
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2587619
uniprot
proteins
pubmed
3233219
uniprot
proteins
pubmed
3675576
uniprot
proteins
pubmed
3782137
uniprot
proteins
pubmed
8031147
uniprot
proteins
pubmed
9058590
uniprot
proteins
pubmed
9348445
uniprot
proteins
pubmed
9918138
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P05182}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05182}. Microsome membrane {ECO:0000250|UniProtKB:P05182}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05182}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P05182}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05182}. Note=Post-translationally targeted to mitochondria. TOMM70 is required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein. {ECO:0000250|UniProtKB:P05182}.
uniprot
proteins