Parva
entrez
57342
canonical
uniprot
Q9EPC1
canonical
ensembl
ENSMUSG00000030770
resolver
ensp
ENSMUSP00000033030
resolver
ensp
ENSMUSP00000102251
resolver
ensp
ENSMUSP00000102254
resolver
enst
ENSMUST00000033030
resolver
enst
ENSMUST00000106640
resolver
enst
ENSMUST00000106643
resolver
genesymbol
Parva
resolver
genesymbol_syn
Actp
resolver
uniprot
F6ZID2
resolver
uniprot
Q3UF75
resolver
uniprot
Q9JJ65
resolver
uniprot_entry
F6ZID2_MOUSE
resolver
uniprot_entry
PARVA_MOUSE
resolver
uniprot_entry
Q3UF75_MOUSE
resolver
uniprot_sec
Q9JJ65
resolver
amino_acid_sequence
MATSPQKSPLVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSEFQEEGMNAINLPLSPISFELDPEDTLLEENEVRTMVDPNSRNDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINETLKLPPRSIKWNVDSVHAKNLVAILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELMQDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVE
uniprot
proteins
function
FUNCTION: Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development. Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (By similarity). {ECO:0000250|UniProtKB:Q9NVD7, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:19798050}.
uniprot
proteins
mass_dalton
42330
uniprot
proteins
protein_family
Parvin family
uniprot
proteins
pubmed
11134073
uniprot
proteins
pubmed
11171322
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16860736
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19798050
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line.
uniprot
proteins