RPSA2
entrez
388524
canonical
uniprot
A0A8I5KQE6
canonical
ensembl
ENSG00000288920
resolver
ensp
ENSP00000509526
resolver
ensp
ENSP00000547962
resolver
ensp
ENSP00000547963
resolver
ensp
ENSP00000547964
resolver
ensp
ENSP00000547965
resolver
ensp
ENSP00000587071
resolver
ensp
ENSP00000587072
resolver
ensp
ENSP00000587073
resolver
ensp
ENSP00000619663
resolver
ensp
ENSP00000619664
resolver
ensp
ENSP00000619665
resolver
enst
ENST00000484897
resolver
enst
ENST00000877903
resolver
enst
ENST00000877904
resolver
enst
ENST00000877905
resolver
enst
ENST00000877906
resolver
enst
ENST00000917012
resolver
enst
ENST00000917013
resolver
enst
ENST00000917014
resolver
enst
ENST00000949604
resolver
enst
ENST00000949605
resolver
enst
ENST00000949606
resolver
genesymbol
RPSA2
resolver
genesymbol_syn
RPSA
resolver
genesymbol_syn
RPSAP58
resolver
hgnc
HGNC:36809
resolver
uniprot_entry
RPSA2_HUMAN
resolver
amino_acid_sequence
MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEHYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFWEPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPSPEFTATQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS
uniprot
proteins
function
FUNCTION: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. {ECO:0000255|HAMAP-Rule:MF_03016}.
uniprot
proteins
mass_dalton
32909
uniprot
proteins
post_translational_modification
PTM: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association. {ECO:0000255|HAMAP-Rule:MF_03016}.; PTM: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions. {ECO:0000255|HAMAP-Rule:MF_03016}.
uniprot
proteins
protein_family
Universal ribosomal protein uS2 family
uniprot
proteins
pubmed
15057824
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_03016}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03016}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with PPP1R16B in the cell membrane. {ECO:0000255|HAMAP-Rule:MF_03016}.
uniprot
proteins