P23819
uniprot
P23819
canonical
amino_acid_sequence
MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYGIESVKI
uniprot
proteins
function
FUNCTION: Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250|UniProtKB:P19491, ECO:0000250|UniProtKB:P42262}.
uniprot
proteins
mass_dalton
98662
uniprot
proteins
mutagenesis
MUTAGEN 869; /note="Y->F: No effect on tyrosine phosphorylation. Reduced tyrosine phosphorylation; when associated with F-873 and F-876."; /evidence="ECO:0000269|PubMed:15240807"; MUTAGEN 873; /note="Y->F: No effect on tyrosine phosphorylation. Reduced tyrosine phosphorylation; when associated with F-869 and F-876."; /evidence="ECO:0000269|PubMed:15240807"; MUTAGEN 876; /note="Y->F: Loss of tyrosine phosphorylation at the C-terminus. Reduced tyrosine phosphorylation; when associated with F-869 and F-873. Interferes with accumulation at synapses. Interferes with AMPA-mediated receptor internalization."; /evidence="ECO:0000269|PubMed:15240807
uniprot
proteins
post_translational_modification
PTM: Palmitoylated (PubMed:16129400). Depalmitoylated upon L-glutamate stimulation (PubMed:16129400). ZDHHC3/GODZ specifically palmitoylates Cys-610, which leads to Golgi retention and decreased cell surface expression (PubMed:16129400). In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (PubMed:16129400). {ECO:0000269|PubMed:16129400}.; PTM: N-glycosylated. {ECO:0000269|PubMed:14687553}.; PTM: Ubiquitinated by RNF167, leading to its degradation. {ECO:0000250|UniProtKB:P42262}.; PTM: Phosphorylation at Tyr-876 is required for interaction with IQSEC1 and ARF6 activation, which in turn triggers AMPAR internalization for persistent synaptic depression. {ECO:0000250|UniProtKB:P19491}.
uniprot
proteins
protein_family
GRIA2 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
10340301
uniprot
proteins
pubmed
10501226
uniprot
proteins
pubmed
10558890
uniprot
proteins
pubmed
12458226
uniprot
proteins
pubmed
14687553
uniprot
proteins
pubmed
15240807
uniprot
proteins
pubmed
16129400
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1699805
uniprot
proteins
pubmed
1717158
uniprot
proteins
pubmed
18341993
uniprot
proteins
pubmed
20152115
uniprot
proteins
pubmed
20547133
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21496646
uniprot
proteins
pubmed
23524343
uniprot
proteins
pubmed
25218043
uniprot
proteins
pubmed
7545935
uniprot
proteins
sequence_length
883
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P42262}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P42262}. Postsynaptic cell membrane {ECO:0000269|PubMed:20547133}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P42262}. Postsynaptic density membrane {ECO:0000269|PubMed:20547133}; Multi-pass membrane protein {ECO:0000255}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity). Displays a somatodendritic localization and is excluded from axons in neurons (PubMed:18341993). {ECO:0000250|UniProtKB:P19491, ECO:0000269|PubMed:18341993}.
uniprot
proteins
transmembrane_region
TRANSMEM 544..564; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 617..637; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 813..833; /note="Helical; Name=M4"; /evidence="ECO:0000250
uniprot
proteins