Kcnn2
entrez
140492
canonical
uniprot
P58390
canonical
ensembl
ENSMUSG00000054477
resolver
ensp
ENSMUSP00000148153
resolver
genesymbol
Kcnn2
resolver
genesymbol_syn
Sk2
resolver
uniprot
A0A1B0GT12
resolver
uniprot
B4YDY0
resolver
uniprot
E9QNY5
resolver
uniprot
Q3UF29
resolver
uniprot
Q540U9
resolver
uniprot
Q8C7F3
resolver
uniprot
Q8CCH4
resolver
uniprot_entry
KCNN2_MOUSE
resolver
uniprot_entry
Q8C7F3_MOUSE
resolver
uniprot_sec
A0A1B0GT12
resolver
uniprot_sec
B4YDY0
resolver
uniprot_sec
E9QNY5
resolver
uniprot_sec
Q3UF29
resolver
uniprot_sec
Q540U9
resolver
uniprot_sec
Q8CCH4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by bee venom neurotoxin apamin (PubMed:11557517, PubMed:13679367, PubMed:14657188). Inhibited by UCL 1684 and tetraethylammonium (TEA) (By similarity). {ECO:0000250|UniProtKB:P70604, ECO:0000269|PubMed:11557517, ECO:0000269|PubMed:13679367, ECO:0000269|PubMed:14657188}.
uniprot
proteins
amino_acid_sequence
MSSCRYNGGVMRPLSNLSSSRRNLQEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVSYNAERSRSSSRRRRSSSTAPPTSSESS
uniprot
proteins
function
FUNCTION: Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:11557517, PubMed:13679367, PubMed:14657188). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:14657188). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (PubMed:13679367). The inward rectification could be due to a blockade of the outward current by intracellular divalent cations such as calcium and magnesium and could also be due to an intrinsic property of the channel pore, independent of intracellular divalent ions. There are three positively charged amino acids in the S6 transmembrane domain, close to the pore, that collectively control the conductance and rectification through an electrostatic mechanism. Additionally, electrostatic contributions from these residues also play an important role in determining the intrinsic open probability of the channel in the absence of calcium, affecting the apparent calcium affinity for activation. Forms an heteromeric complex with calmodulin, which is constitutively associated in a calcium-independent manner. Channel opening is triggered when calcium binds the calmodulin resulting in a rotary movement leading to the formation of the dimeric complex to open the gate (By similarity). Plays a role in the repolarization phase of cardiac action potential (By similarity). {ECO:0000250|UniProtKB:P70604, ECO:0000250|UniProtKB:Q9H2S1, ECO:0000269|PubMed:11557517, ECO:0000269|PubMed:13679367, ECO:0000269|PubMed:14657188}.
uniprot
proteins
mass_dalton
63482
uniprot
proteins
protein_family
KCa2.2/KCNN2 subfamily
uniprot
proteins
protein_family
Potassium channel KCNN family
uniprot
proteins
pubmed
11557517
uniprot
proteins
pubmed
13679367
uniprot
proteins
pubmed
14657188
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16055520
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18624921
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20689065
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26880549
uniprot
proteins
sequence_length
574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:20689065}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:18624921}.
uniprot
proteins
transmembrane_region
TRANSMEM 133..153; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 209..229; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 251..271; /note="Helical; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 300..320; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 369..389; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins