Arap3
entrez
106952
canonical
uniprot
Q8R5G7
canonical
ensembl
ENSMUSG00000024451
resolver
ensp
ENSMUSP00000035662
resolver
ensp
ENSMUSP00000157868
resolver
ensp
ENSMUSP00000189167
resolver
genesymbol
Arap3
resolver
genesymbol_syn
Centd3
resolver
genesymbol_syn
Drag1
resolver
genesymbol_syn
Kiaa4097
resolver
uniprot
E9QMK7
resolver
uniprot
Q5DTN4
resolver
uniprot
Q6NVF1
resolver
uniprot
Q8R5G6
resolver
uniprot_entry
ARAP3_MOUSE
resolver
uniprot_sec
E9QMK7
resolver
uniprot_sec
Q5DTN4
resolver
uniprot_sec
Q6NVF1
resolver
uniprot_sec
Q8R5G6
resolver
amino_acid_sequence
MAAPQDLDIAVWLALVHLEQYADTFRRHGLATAGAAQHLGHEELRHLGISATGHRKRILRLLRAGSAEGFLDSHLDNTMEPTPSPAPDAQPPKPVPKPRTVFGLSNPATAQRPGLSPIFWDPEVSRNSECTQRSSPLLPSSSEQPSVPNTMEMMPNAIYFGLDLRGRAQAAQDVTPDSSQATVPTPAFRPTTGTVHIMDPGCLYYGVQPVGIPGASDRRDGRGVCQERAEHRQDLETREDAGYASLELPGDSILSLPTQDAETSDDLISPYASFSSTADRPVPLLSGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDLWCSTLQSCLKEQRLLGHPRPPHPPRPLRTGTLELRGHKAKVFAALIPGELALYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKVWSNPANRHCADCRASRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANCFWAGALPPGEGLHPDSAPGPRGEFISRKYKLGLFRKPHPRHPDHSQLLQALCAAMAGPNLLKNMAQLLCVETSEGEEPLSPSALNGSLLSLLPSDSPGVYNEVVVPATYRGFLYCGSISNKAGAPPLRRGRDAPPRLWCVLGAALEMFASESSPEPLSLLQPQDIVCLGVSPPPADPGDLDRFPFSFELILTGGRIQHFATDGADSLEAWISAVGKWFSPLSCHQLLGPGLLRMGRLWLRSPSHAGLAPGLWLSGFGLLRGDHLFLCPAPGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRLDFAAWNTAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVKLRPREHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELSQKNQRLEKYKEVISCLPRVNRRTLATLIGHLYRVQKCASLNQMCTRNLALLFAPSVFQTDGRGEHEVRVLQELIDGYISVFDIDSDQAAQIDLEVSLITTWKDVQLSQAGDLIMEVYIEQQLPDNCVTLKVSPTLTAEELTNQVLEMRGAASGTDLWVTFEILEHGELERPLHPKEKVLEQALQWCQLPEPCSASLLLRKVSMAHAGCLFTGVRRESPRVGLLRCREEPPRLLGNRFQERFFLVRGRCLLLLKEKKSSKPEREWSLEGAKVYLGIRKKLKPPTLWGFTLILEKMHLCLSCMDEEEMWDWTTSILKAQHDDQQSVVLRRRSSSDLARQKFGTMPLLPIRGDDSGATLLSANQTLRRLHNRRTLSMFFPMKSPQGSVEEQDELEEPVYEEPVYEEVGAFPELTKDTTFSSTWEWSAKSDPSLTSQRSFDQPPLSKASMLGHEERIPDPPPGPPSKSSSQARGSLEEQLLQELNNLILRKGEPASCPESSSQPTSPQAPSPTSLPTPTPSLPTQPPCTSNPPSSQPLT
uniprot
proteins
function
FUNCTION: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts preferentially on ARF5 and on RHOA. {ECO:0000269|PubMed:15546919}.
uniprot
proteins
mass_dalton
169741
uniprot
proteins
mutagenesis
MUTAGEN 938; /note="R->L: Loss of Rho GAP activity. Enhances cell spreading."; /evidence="ECO:0000269|PubMed:15546919"; MUTAGEN 1399; /note="Y->F: Strongly reduces phosphorylation by CSK; when associated with F-1404."; /evidence="ECO:0000269|PubMed:15546919"; MUTAGEN 1404; /note="Y->F: Strongly reduces phosphorylation by CSK; when associated with F-1399."; /evidence="ECO:0000269|PubMed:15546919
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated at a low basal level. PDGF treatment stimulates phosphorylation. Tyrosine phosphorylation is increased in cells that are in the process of becoming attached to a substrate and that start spreading and flattening. {ECO:0000269|PubMed:15546919}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15546919
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15546919}. Cell membrane {ECO:0000269|PubMed:15546919}; Peripheral membrane protein {ECO:0000269|PubMed:15546919}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15546919}. Cell projection, lamellipodium {ECO:0000269|PubMed:15546919}. Cell projection, ruffle {ECO:0000269|PubMed:15546919}. Note=Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia.
uniprot
proteins