BNIP3L
entrez
665
canonical
uniprot
O60238
canonical
ensembl
ENSG00000104765
resolver
ensp
ENSP00000370003
resolver
ensp
ENSP00000429851
resolver
genesymbol
BNIP3L
resolver
genesymbol_syn
BNIP3A
resolver
genesymbol_syn
BNIP3H
resolver
genesymbol_syn
NIX
resolver
hgnc
HGNC:1085
resolver
uniprot
B0AZS9
resolver
uniprot
Q5JW63
resolver
uniprot
Q6IBV1
resolver
uniprot
Q8NF87
resolver
uniprot_entry
BNI3L_HUMAN
resolver
uniprot_entry
Q6IBV1_HUMAN
resolver
uniprot_sec
B0AZS9
resolver
uniprot_sec
Q5JW63
resolver
uniprot_sec
Q8NF87
resolver
amino_acid_sequence
MSSHLVEPPPPLHNNNNNCEENEQSLPPPAGLNSSWVELPMNSSNGNDNGNGKNGGLEHVPSSSSIHNGDMEKILLDAQHESGQSSSRGSSHCDSPSPQEDGQIMFDVEMHTSRDHSSQSEEEVVEGEKEVEALKKSADWVSDWSSRPENIPPKEFHFRHPKRSVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSHVLALGLGIYIGKRLSTPSASTY
uniprot
proteins
function
FUNCTION: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}.
uniprot
proteins
mass_dalton
23930
uniprot
proteins
post_translational_modification
PTM: Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.
uniprot
proteins
protein_family
NIP3 family
uniprot
proteins
pubmed
10381623
uniprot
proteins
pubmed
12606722
uniprot
proteins
pubmed
12663450
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21264228
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
31324791
uniprot
proteins
pubmed
38992176
uniprot
proteins
pubmed
9523198
uniprot
proteins
pubmed
9867803
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Colocalizes with SPATA18 at the mitochondrion outer membrane.
uniprot
proteins
transmembrane_region
TRANSMEM 188..208; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins