KANSL3
entrez
55683
canonical
uniprot
Q9P2N6
canonical
ensembl
ENSG00000114982
resolver
ensp
ENSP00000396749
resolver
ensp
ENSP00000499674
resolver
ensp
ENSP00000553067
resolver
ensp
ENSP00000553069
resolver
ensp
ENSP00000553073
resolver
ensp
ENSP00000618632
resolver
ensp
ENSP00000618633
resolver
ensp
ENSP00000618635
resolver
ensp
ENSP00000618636
resolver
ensp
ENSP00000748179
resolver
ensp
ENSP00000784974
resolver
genesymbol
KANSL3
resolver
genesymbol_syn
KIAA1310
resolver
genesymbol_syn
NSL3
resolver
genesymbol_syn
PRTD
resolver
genesymbol_syn
SI1
resolver
hgnc
HGNC:25473
resolver
uniprot
A1L184
resolver
uniprot
D3DXH3
resolver
uniprot
D3DXH4
resolver
uniprot
Q05BU4
resolver
uniprot
Q6P3X2
resolver
uniprot
Q6PJH6
resolver
uniprot
Q86T19
resolver
uniprot
Q96L64
resolver
uniprot
Q9H0C9
resolver
uniprot
Q9H8C9
resolver
uniprot
Q9HAP8
resolver
uniprot
Q9NWE5
resolver
uniprot_entry
KANL3_HUMAN
resolver
uniprot_sec
A1L184
resolver
uniprot_sec
D3DXH3
resolver
uniprot_sec
D3DXH4
resolver
uniprot_sec
Q05BU4
resolver
uniprot_sec
Q6P3X2
resolver
uniprot_sec
Q6PJH6
resolver
uniprot_sec
Q86T19
resolver
uniprot_sec
Q96L64
resolver
uniprot_sec
Q9H0C9
resolver
uniprot_sec
Q9H8C9
resolver
uniprot_sec
Q9HAP8
resolver
uniprot_sec
Q9NWE5
resolver
amino_acid_sequence
MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRMLFVTPRRQHESTIESDVPIDVETVTSTPMPLYDNQKARSVMNECERHVIFARTDADAPPPPEDWEEHVNRTGWTMAQNKLFNKILKALQSDRLARLANEGACNEPVLRRVAVDKCARRVRQALASVSWDTKLIQWLHTTLVETLSLPMLAAYLDALQTLKGKIPTLIDRMLVSSNTKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIASSGPSSSVFPTSRRHRFWQSQLSCLGKVIPVATHLLNNGSGVGVLQCLEHMIGAVRSKVLEIHSHFPHKPIILIGWNTGALVACHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDPLLDMKTPVLFVIGQNSLQCHPEAMEDFREKIRAENSLVVVGGADDNLRISKAKKKSEGLTQSMVDRCIQDEIVDFLTGVLTRAEGHMGSEPRDQDAEKKKKPRDVARRDLAFEVPERGSRPASPAAKLPASPSGSEDLSSVSSSPTSSPKTKVTTVTSAQKSSQIGSSQLLKRHVQRTEAVLTHKQAQAQFAAFLKQNMLVRKALPPGTSSCLFVPISSEPPEEGEKEDLRVQLKRHHPSSPLPGSKTSKRPKIKVSLISQGDTAGGPCAPSQGSAPEAAGGKPITMTLGQASAGAKELTGLLTTAKSSSSEGGVSASPVPSVVSSSTAPSALHTLQSRLVATSPGSSLPGATSASSLLQGLSFSLQDISSKTSGLPANPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLGATPGGKPTAIHQLLTNGGLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGAAPSEESSSQVLPSSSQRLPPAP
uniprot
proteins
function
FUNCTION: Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA (PubMed:27768893). Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells (By similarity). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (By similarity). Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (By similarity). Plays an essential role in spindle assembly during mitosis (PubMed:26243146). Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly (PubMed:26243146). Indispensable during early embryonic development where it is required for proper lineage specification and maintenance during peri-implantation development and is essential for implantation (By similarity). {ECO:0000250|UniProtKB:A2RSY1, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}.
uniprot
proteins
mass_dalton
95992
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16543150
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20018852
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26243146
uniprot
proteins
pubmed
27768893
uniprot
proteins
pubmed
33657400
uniprot
proteins
sequence_length
904
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:26243146}. Mitochondrion {ECO:0000269|PubMed:27768893}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:26243146}. Note=Concentrated in the nucleus during interphase but displays a marked relocalization to the spindle poles during mitosis. {ECO:0000269|PubMed:26243146}.
uniprot
proteins