Aqp9
entrez
64008
canonical
uniprot
Q9JJJ3
canonical
ensembl
ENSMUSG00000032204
resolver
ensp
ENSMUSP00000050127
resolver
ensp
ENSMUSP00000074063
resolver
ensp
ENSMUSP00000109200
resolver
ensp
ENSMUSP00000290791
resolver
enst
ENSMUST00000060917
resolver
enst
ENSMUST00000074465
resolver
enst
ENSMUST00000113570
resolver
genesymbol
Aqp9
resolver
uniprot
D3YYD6
resolver
uniprot
Q4FK77
resolver
uniprot_entry
AQP9_MOUSE
resolver
uniprot_entry
D3YYD6_MOUSE
resolver
uniprot_entry
Q4FK77_MOUSE
resolver
amino_acid_sequence
MPSEKDRAKKNLVQRLALKSCLAKETLSEFLGTFIMIVLGCGSIAQAVLSREKAGGIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEWFKFPFYVGAQLLGAFVGAATVFGIYYDGLMAFADGKLLITGENGTAFIFATYPKPFVSVPGAFVDQVVSTMFLLLIVFAIFDSRNLGVPRGLEPIVIGLLIIVISCSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFTFGNNFWWIPVVGPMIGAVLGGLIYVLFIQMHHSNPDPEVKAEPAENNLEKHELSVIM
uniprot
proteins
function
FUNCTION: Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:22081610). AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis (PubMed:17360690, PubMed:22081610). It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines (By similarity). AQP9 may also facilitate hepatic urea extrusion (PubMed:22081610, PubMed:23042941). Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy (PubMed:32748371). Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity (PubMed:11972053, PubMed:19805235). It is also permeable to H2O2 in vivo (PubMed:26837049). Could also be permeable to ammonium (By similarity). {ECO:0000250|UniProtKB:P56627, ECO:0000269|PubMed:11972053, ECO:0000269|PubMed:17360690, ECO:0000269|PubMed:19805235, ECO:0000269|PubMed:22081610, ECO:0000269|PubMed:23042941, ECO:0000269|PubMed:26837049, ECO:0000269|PubMed:32748371}.
uniprot
proteins
mass_dalton
31764
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
10777495
uniprot
proteins
pubmed
11972053
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17360690
uniprot
proteins
pubmed
19805235
uniprot
proteins
pubmed
22081610
uniprot
proteins
pubmed
23042941
uniprot
proteins
pubmed
26837049
uniprot
proteins
pubmed
32748371
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:23042941}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96PS8}. Basolateral cell membrane {ECO:0000305|PubMed:23042941}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96PS8}. Note=Functions at the hepatocyte basolateral membrane. {ECO:0000269|PubMed:23042941}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..43; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q96PS8"; TRANSMEM 58..77; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q96PS8"; TRANSMEM 99..123; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q96PS8"; TRANSMEM 161..178; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q96PS8"; TRANSMEM 191..207; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q96PS8"; TRANSMEM 244..264; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q96PS8
uniprot
proteins