ADIPOR1
entrez
51094
canonical
uniprot
Q96A54
canonical
ensembl
ENSG00000159346
resolver
ensp
ENSP00000341785
resolver
ensp
ENSP00000525761
resolver
ensp
ENSP00000525762
resolver
ensp
ENSP00000525765
resolver
ensp
ENSP00000525766
resolver
ensp
ENSP00000525767
resolver
ensp
ENSP00000525769
resolver
ensp
ENSP00000610266
resolver
ensp
ENSP00000613020
resolver
ensp
ENSP00000613021
resolver
ensp
ENSP00000613024
resolver
ensp
ENSP00000613025
resolver
ensp
ENSP00000613026
resolver
enst
ENST00000340990
resolver
enst
ENST00000855702
resolver
enst
ENST00000855703
resolver
enst
ENST00000855706
resolver
enst
ENST00000855707
resolver
enst
ENST00000855708
resolver
enst
ENST00000855710
resolver
enst
ENST00000940207
resolver
enst
ENST00000942961
resolver
enst
ENST00000942962
resolver
enst
ENST00000942965
resolver
enst
ENST00000942966
resolver
enst
ENST00000942967
resolver
genesymbol
ADIPOR1
resolver
genesymbol_syn
PAQR1
resolver
genesymbol_syn
TESBP1A
resolver
hgnc
HGNC:24040
resolver
uniprot
B3KMB0
resolver
uniprot
Q53HS7
resolver
uniprot
Q53YY6
resolver
uniprot
Q9Y360
resolver
uniprot_entry
PAQR1_HUMAN
resolver
uniprot_sec
B3KMB0
resolver
uniprot_sec
Q53HS7
resolver
uniprot_sec
Q53YY6
resolver
uniprot_sec
Q9Y360
resolver
amino_acid_sequence
MSSHKGSVVAQGNGAPASNREADTVELAELGPLLEEKGKRVIANPPKAEEEQTCPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEGRWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGFVKATTVGQMGWFFLMAVMYITGAGLYAARIPERFFPGKFDIWFQSHQIFHVLVVAAAFVHFYGVSNLQEFRYGLEGGCTDDTLL
uniprot
proteins
function
FUNCTION: Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity). {ECO:0000250|UniProtKB:Q91VH1, ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}.
uniprot
proteins
mass_dalton
42616
uniprot
proteins
mutagenesis
MUTAGEN 161..167; /note="MYFMAPL->SGSSGGS: Decreases activation of AMPK in response to ADIPOQ binding; when associated with 229-G--G-231 and 291-S--S-297."; /evidence="ECO:0000269|PubMed:25855295"; MUTAGEN 191; /note="H->A: Decreases activation of AMPK in response to ADIPOQ binding; when associated with A-208; A-337 and A-341."; /evidence="ECO:0000269|PubMed:25855295"; MUTAGEN 208; /note="D->A: Decreases activation of AMPK in response to ADIPOQ binding; when associated with A-191; A-337 and A-341."; /evidence="ECO:0000269|PubMed:25855295"; MUTAGEN 229..231; /note="YCS->GGG: Decreases activation of AMPK in response to ADIPOQ binding; when associated with 161-S--S-167 and 291-S--S-297."; /evidence="ECO:0000269|PubMed:25855295"; MUTAGEN 291..297; /note="FVKATTV->SSSGGGS: Decreases activation of AMPK in response to ADIPOQ binding; when associated with 161-S--S-167 and 229-G--G-231."; /evidence="ECO:0000269|PubMed:25855295"; MUTAGEN 337; /note="H->A: Decreases activation of AMPK in response to ADIPOQ binding; when associated with A-191; A-208 and A-341."; /evidence="ECO:0000269|PubMed:25855295"; MUTAGEN 341; /note="H->A: Decreases activation of AMPK in response to ADIPOQ binding; when associated with A-191; A-208 and A-337."; /evidence="ECO:0000269|PubMed:25855295
uniprot
proteins
protein_family
ADIPOR family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
12802337
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16044242
uniprot
proteins
pubmed
25855295
uniprot
proteins
pubmed
34887495
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}; Multi-pass membrane protein {ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}. Note=Localized to the cell membrane and intracellular organelles. {ECO:0000269|PubMed:12802337}.
uniprot
proteins
transmembrane_region
TRANSMEM 137..157; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:25855295"; TRANSMEM 171..191; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:25855295"; TRANSMEM 204..224; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:25855295"; TRANSMEM 235..255; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:25855295"; TRANSMEM 265..285; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:25855295"; TRANSMEM 299..319; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:25855295"; TRANSMEM 338..358; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:25855295
uniprot
proteins