Alas2
entrez
11656
canonical
uniprot
P08680
canonical
ensembl
ENSMUSG00000025270
resolver
ensp
ENSMUSP00000066040
resolver
ensp
ENSMUSP00000108335
resolver
ensp
ENSMUSP00000243005
resolver
ensp
ENSMUSP00000243007
resolver
enst
ENSMUST00000066337
resolver
enst
ENSMUST00000112715
resolver
genesymbol
Alas2
resolver
uniprot
A2AFM0
resolver
uniprot
A2AFM1
resolver
uniprot
Q64452
resolver
uniprot
Q9DCN0
resolver
uniprot_entry
A2AFM0_MOUSE
resolver
uniprot_entry
A2AFM1_MOUSE
resolver
uniprot_entry
HEM0_MOUSE
resolver
uniprot_sec
Q64452
resolver
uniprot_sec
Q9DCN0
resolver
amino_acid_sequence
MVAAAMLLRSCPVLSQGPTGLLGKVAKTYQFLFSIGRCPILATQGPTCSQIHLKATKAGGDSPSWAKSHCPFMLSELQDRKSKIVQRAAPEVQEDVKTFKTDLLSTMDSTTRSHSFPSFQEPEQTEGAVPHLIQNNMTGSQAFGYDQFFRDKIMEKKQDHTYRVFKTVNRWANAYPFAQHFSEASMASKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALTFVDEVHAVGLYGARGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGFPVIPCPSHIIPIRVGNAALNSKICDLLLSKHSIYVQAINYPTVPRGEELLRLAPSPHHSPQMMENFVEKLLLAWTEVGLPLQDVSVAACNFCHRPVHFELMSEWERSYFGNMGPQYVTTYA
uniprot
proteins
ec_number
2.3.1.37
uniprot
proteins
function
FUNCTION: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (PubMed:3557128, PubMed:8268805). Contributes significantly to heme formation during erythropoiesis (By similarity). {ECO:0000250|UniProtKB:P22557, ECO:0000269|PubMed:3557128, ECO:0000269|PubMed:8268805}.
uniprot
proteins
mass_dalton
64753
uniprot
proteins
mutagenesis
MUTAGEN 391; /note="K->A,H: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:8268805
uniprot
proteins
pathway_participation
PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1. {ECO:0000250|UniProtKB:P22557}.
uniprot
proteins
protein_family
Class-II pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
11566198
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
3557128
uniprot
proteins
pubmed
8268805
uniprot
proteins
sequence_length
587
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P22557}; Peripheral membrane protein {ECO:0000250|UniProtKB:P22557}. Mitochondrion {ECO:0000269|PubMed:3557128}. Note=Localizes to the matrix side of the mitochondrion inner membrane. {ECO:0000250|UniProtKB:P22557}.
uniprot
proteins