Deaf1
entrez
54006
canonical
uniprot
Q9Z1T5
canonical
ensembl
ENSMUSG00000058886
resolver
ensp
ENSMUSP00000079395
resolver
ensp
ENSMUSP00000175999
resolver
ensp
ENSMUSP00000176002
resolver
ensp
ENSMUSP00000176004
resolver
ensp
ENSMUSP00000327089
resolver
genesymbol
Deaf1
resolver
uniprot
C7SHZ9
resolver
uniprot
Q3TYJ5
resolver
uniprot
Q3UJA4
resolver
uniprot
Q80V49
resolver
uniprot_entry
DEAF1_MOUSE
resolver
uniprot_entry
Q3TYJ5_MOUSE
resolver
uniprot_entry
Q80V49_MOUSE
resolver
uniprot_sec
C7SHZ9
resolver
uniprot_sec
Q3UJA4
resolver
amino_acid_sequence
MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAESEAEEPVLSRDEDSEEDADSEAERETRRVTAVAVMAAESGHMDMGTEALPSPDEAAAAAAAFAEVTTVTVANVGSSADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKSRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKENELPTTPVKKDSPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATVQEAGVQPPCRVGHPEPHYPGYQDSCQIAPFPEAALPTSHPKIVLTSLPALAVPPSTPTKAVSPTVVSGLEMSEHRSWLYLEEMVNSLLNTAQQLKTLFEQAKQASSCREAAVTQARMQVDTERKEQSCVNCGREAMSECTGCHKVNYCSTFCQRKDWKDHQHVCGQSASVTVQADDVHVEESVIEKVAV
uniprot
proteins
function
FUNCTION: Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction (By similarity). Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 2. Isoform 2 may inhibit transcriptional activity of isoform 1 by interacting with it and retaining it in the cytoplasm. Transcriptional activator of EIF4G3 (By similarity). May also involved in behavior (PubMed:24726472). {ECO:0000250|UniProtKB:O75398, ECO:0000269|PubMed:14966286, ECO:0000269|PubMed:18826651, ECO:0000269|PubMed:19668219, ECO:0000269|PubMed:24726472}.
uniprot
proteins
mass_dalton
59633
uniprot
proteins
mutagenesis
MUTAGEN 305; /note="K->T: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:22723967
uniprot
proteins
post_translational_modification
PTM: May be phosphorylated by DNA-PK complex in a DNA independent manner (in vitro). {ECO:0000250}.
uniprot
proteins
pubmed
14966286
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18826651
uniprot
proteins
pubmed
19668219
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22723967
uniprot
proteins
pubmed
24726472
uniprot
proteins
pubmed
9860983
uniprot
proteins
sequence_length
566
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. Cytoplasm {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus. Note=Displays some nuclear localization when expressed with isoform 1, suggesting that it may heterodimerize with isoform 1 and shuttle to the nucleus using the nuclear localization signal of isoform 1.
uniprot
proteins