Mief1
entrez
239555
canonical
uniprot
Q8BGV8
canonical
ensembl
ENSMUSG00000022412
resolver
ensp
ENSMUSP00000023048
resolver
ensp
ENSMUSP00000129209
resolver
ensp
ENSMUSP00000154875
resolver
ensp
ENSMUSP00000236967
resolver
ensp
ENSMUSP00000236969
resolver
ensp
ENSMUSP00000236973
resolver
ensp
ENSMUSP00000236979
resolver
ensp
ENSMUSP00000331639
resolver
enst
ENSMUST00000023048
resolver
enst
ENSMUST00000166030
resolver
enst
ENSMUST00000229138
resolver
genesymbol
Mief1
resolver
genesymbol_syn
Mid51
resolver
genesymbol_syn
Smcr7l
resolver
uniprot
B2RPW2
resolver
uniprot
Q8C4Y9
resolver
uniprot_entry
B2RPW2_MOUSE
resolver
uniprot_entry
MID51_MOUSE
resolver
uniprot_sec
Q8C4Y9
resolver
amino_acid_sequence
MAGAGERKGKKDDNGIGTAIDFVLSNARLVLGVGGAAMLGIATLAVKRMYDRAISAPTSPTRLSHSGKRSWEEPNWMGSPRLLNKDMKAGLSRSLQTLPTDSSAFDTDTFCPPRPKPLARRGQVDLKKSRLRMSLQEKLLSYYRNRAAIPAGEQARAKQAAVDICAELRSFLRAKLPDMPLRDMYLSGSLYDDLQVVTADHIQLIVPLVLEQNLWSCIPGEDTIMNVPGFFLVRRENPEYFPRGSSYWDRCVVGGYLSPKTVADTFEKVVAGSINWPAIGSLLDYVIRPAPPPEALTLEVQYEKDKHLVIDFLPSVTLGDTVLVARPHRLAQYDNLWRLSLRPAETARLRALDQADSGCRSLCLKILKAICKSTPALGHLTASQLTNVILHLAQEEADWSPDMLADRFLQALRGLISYLEAGVLPSALNPKVNLFAELTPQEIDELGYTLYCSLSEPEVLLQT
uniprot
proteins
function
FUNCTION: Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. {ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:24508339}.
uniprot
proteins
mass_dalton
51184
uniprot
proteins
mutagenesis
MUTAGEN 189; /note="S->A: Abolishes ADP binding."; /evidence="ECO:0000269|PubMed:24508339"; MUTAGEN 201; /note="H->A: Abolishes ADP binding."; /evidence="ECO:0000269|PubMed:24508339"; MUTAGEN 234..237; /note="RREN->AAEA: Abolishes interaction with DNM1L."; MUTAGEN 239..243; /note="EYFPR->AAFPA: Impairs interaction with DNM1L."; MUTAGEN 253..255; /note="VGG->EEE: Impairs interaction with DNM1L."; MUTAGEN 368; /note="K->A: Mildly reduces affinity for ADP."; /evidence="ECO:0000269|PubMed:24508339
uniprot
proteins
protein_family
MID49/MID51 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23283981
uniprot
proteins
pubmed
24508339
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:24508339}; Single-pass membrane protein {ECO:0000269|PubMed:24508339}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..46; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins