RAB29
entrez
8934
canonical
uniprot
O14966
canonical
ensembl
ENSG00000117280
resolver
ensp
ENSP00000235932
resolver
ensp
ENSP00000356107
resolver
ensp
ENSP00000389899
resolver
ensp
ENSP00000416613
resolver
ensp
ENSP00000565214
resolver
ensp
ENSP00000565215
resolver
ensp
ENSP00000565216
resolver
ensp
ENSP00000565217
resolver
ensp
ENSP00000680401
resolver
ensp
ENSP00000680405
resolver
ensp
ENSP00000680406
resolver
ensp
ENSP00000680410
resolver
ensp
ENSP00000680412
resolver
genesymbol
RAB29
resolver
genesymbol
RAB7L1
resolver
genesymbol_syn
RAB7L1
resolver
hgnc
HGNC:9789
resolver
uniprot
A0A024R999
resolver
uniprot
B2R7I9
resolver
uniprot
B4E1K3
resolver
uniprot
C9JE77
resolver
uniprot
Q6FGU7
resolver
uniprot_entry
B2R7I9_HUMAN
resolver
uniprot_entry
Q6FGU7_HUMAN
resolver
uniprot_entry
RAB7L_HUMAN
resolver
uniprot_sec
A0A024R999
resolver
uniprot_sec
B4E1K3
resolver
uniprot_sec
C9JE77
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MGSRDHLFKVLVVGDAAVGKTSLVQRYSQDSFSKHYKSTVGVDFALKVLQWSDYEIVRLQLWDIAGQERFTSMTRLYYRDASACVIMFDVTNATTFSNSQRWKQDLDSKLTLPNGEPVPCLLLANKCDLSPWAVSRDQIDRFSKENGFTGWTETSVKENKNINEAMRVLIEKMMRNSTEDIMSLSTQGDYINLQTKSSSWSCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:24788816). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB29 is essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:24788816). Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity (PubMed:29212815, PubMed:38127736). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed:38127736). Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.typhi) epithelial cell infection (PubMed:22042847). {ECO:0000250|UniProtKB:Q13637, ECO:0000250|UniProtKB:Q63481, ECO:0000269|PubMed:22042847, ECO:0000269|PubMed:24788816, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:38127736}.
uniprot
proteins
mass_dalton
23155
uniprot
proteins
mutagenesis
MUTAGEN 43; /note="D->A: Abolishes interaction with LRRK2 and reduces membrane localization of LRRK2. Impairs RAB29-stimulated LRRK2 kinase activity on RAB10, RAB29 and LRRK2."; /evidence="ECO:0000269|PubMed:38127736"; MUTAGEN 62; /note="W->A: Abolishes interaction with LRRK2 and reduces membrane localization of LRRK2. Impairs RAB29-stimulated LRRK2 kinase activity on RAB10, RAB29 and LRRK2."; /evidence="ECO:0000269|PubMed:38127736"; MUTAGEN 67; /note="Q->L: Reduces membrane localization of LRRK2 and impairs RAB29-stimulated LRRK2 kinase activity on RAB10 and LRRK2. Reduces membrane localization of LRRK2 and impairs RAB29-stimulated LRRK2 kinase activity on RAB10 and LRRK2; when associated with A-71 and A-72."; /evidence="ECO:0000269|PubMed:38127736"; MUTAGEN 71; /note="T->A: Loss of phosphorylation by LRRK2. Impairs RAB29-stimulated LRRK2 kinase activity on RAB10 and LRRK2; when associated with A-72. Reduces membrane localization of LRRK2 and impairs RAB29-stimulated LRRK2 kinase activity on RAB10 and LRRK2; when associated with L-67 and A-72."; /evidence="ECO:0000269|PubMed:29212815"; MUTAGEN 71; /note="T->E: Loss of phosphorylation by LRRK2. Does not stimulate LRRK2 kinase activity; when associated with E-72."; /evidence="ECO:0000269|PubMed:29212815"; MUTAGEN 72; /note="S->A: Loss of phosphorylation by LRRK2. Impairs RAB29-stimulated LRRK2 kinase activity on RAB10 and LRRK2; when associated with A-71. Reduces membrane localization of LRRK2 and impairs RAB29-stimulated LRRK2 kinase activity on RAB10 and LRRK2; when associated with L-67 and A-71."; /evidence="ECO:0000269|PubMed:29212815"; MUTAGEN 72; /note="S->E: Loss of phosphorylation by LRRK2. Does not stimulate LRRK2 kinase activity; when associated with E-71."; /evidence="ECO:0000269|PubMed:29212815"; MUTAGEN 73; /note="M->S: Loss of LRRK2 binding. Does not stimulate LRRK2 kinase activity. Localized to the cytosol."; /evidence="ECO:0000269|PubMed:29212815"; MUTAGEN 75; /note="R->S: Loss of LRRK2 binding. Does not stimulate LRRK2 kinase activity. Localized to the cytosol."; /evidence="ECO:0000269|PubMed:29212815
uniprot
proteins
post_translational_modification
PTM: In case of Salmonella enterica serovar Typhimurium (S.typhimurium) infection, is proteolytically cleaved between Gly-41 and Val-42 by the GtgE viral protease encoded on the Gifsy-2 lysogen bacteriophage, which therefore prevents the recruitment of RAB29 to S.typhimurium-containing vacuoles. In contrast, no proteolytically cleavage is detected in S.typhi-infected cells (PubMed:22042847). {ECO:0000269|PubMed:22042847}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22042847
uniprot
proteins
pubmed
24788816
uniprot
proteins
pubmed
29212815
uniprot
proteins
pubmed
38127736
uniprot
proteins
pubmed
9284931
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:38127736}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:24788816, ECO:0000269|PubMed:29212815}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:24788816}. Golgi apparatus {ECO:0000269|PubMed:22042847}. Golgi apparatus membrane {ECO:0000269|PubMed:38127736}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:24788816, ECO:0000269|PubMed:29212815}. Vacuole {ECO:0000269|PubMed:22042847}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22042847}. Note=Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (PubMed:29212815). Colocalizes with GM130 at the Golgi apparatus (PubMed:22042847). Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus (PubMed:22042847, PubMed:38127736). Colocalizes with TGN46 at the trans-Golgi network (TGN) (PubMed:24788816). In Salmonella enterica serovar Typhi (S.typhi) infected epithelial cells, is recruited and colocalized with both S.typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery (PubMed:22042847). {ECO:0000269|PubMed:22042847, ECO:0000269|PubMed:24788816, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:38127736}.
uniprot
proteins