SETD7
entrez
80854
canonical
uniprot
Q8WTS6
canonical
ensembl
ENSG00000145391
resolver
ensp
ENSP00000274031
resolver
ensp
ENSP00000385913
resolver
ensp
ENSP00000427300
resolver
enst
ENST00000274031
resolver
enst
ENST00000404104
resolver
enst
ENST00000506866
resolver
genesymbol
SETD7
resolver
genesymbol_syn
KIAA1717
resolver
genesymbol_syn
KMT7
resolver
genesymbol_syn
SET7
resolver
genesymbol_syn
SET9
resolver
hgnc
HGNC:30412
resolver
uniprot
B5MCZ8
resolver
uniprot
B5WWL3
resolver
uniprot
D6RJA0
resolver
uniprot
Q0VAH3
resolver
uniprot
Q4W5A9
resolver
uniprot
Q9C0E6
resolver
uniprot_entry
B5MCZ8_HUMAN
resolver
uniprot_entry
D6RJA0_HUMAN
resolver
uniprot_entry
SETD7_HUMAN
resolver
uniprot_sec
B5WWL3
resolver
uniprot_sec
Q0VAH3
resolver
uniprot_sec
Q4W5A9
resolver
uniprot_sec
Q9C0E6
resolver
amino_acid_sequence
MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK
uniprot
proteins
ec_number
2.1.1.364
uniprot
proteins
function
FUNCTION: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed:11779497, PubMed:11850410, PubMed:12540855, PubMed:12588998, PubMed:16141209). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:12540855, PubMed:12588998, PubMed:16141209). Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:12588998, PubMed:16141209). Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (PubMed:16141209). Also has methyltransferase activity toward non-histone proteins such as CGAS, GLI3, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed:15099517, PubMed:15525938, PubMed:16415881, PubMed:27146893, PubMed:35210392). Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (PubMed:15099517, PubMed:16415881). Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (PubMed:15525938, PubMed:16415881, PubMed:17108971). Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (By similarity). Acts as a positive regulator of smoothened signaling by mediating methylation of full-length GLI3, increasing GLI3 ability to bind DNA (PubMed:27146893). {ECO:0000250|UniProtKB:Q8VHL1, ECO:0000269|PubMed:11779497, ECO:0000269|PubMed:11850410, ECO:0000269|PubMed:12540855, ECO:0000269|PubMed:12588998, ECO:0000269|PubMed:15099517, ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16141209, ECO:0000269|PubMed:16415881, ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:27146893, ECO:0000269|PubMed:35210392}.
uniprot
proteins
mass_dalton
40721
uniprot
proteins
mutagenesis
MUTAGEN 220; /note="E->A: Increases near-attack conformations."; /evidence="ECO:0000269|PubMed:16433545"; MUTAGEN 228; /note="E->A: Increases near-attack conformations."; /evidence="ECO:0000269|PubMed:16433545"; MUTAGEN 245; /note="Y->A: Significantly reduces the monomethyltransferase activity but increases the dimethyltransferase activity."; /evidence="ECO:0000269|PubMed:12540855, ECO:0000269|PubMed:16433545"; MUTAGEN 294; /note="K->A: Significantly reduces the catalytic activity."; /evidence="ECO:0000269|PubMed:16433545"; MUTAGEN 297; /note="H->A,G: Abolishes methyltransferase activity."; /evidence="ECO:0000269|PubMed:11779497, ECO:0000269|PubMed:11850410, ECO:0000269|PubMed:15099517, ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16141209, ECO:0000269|PubMed:27146893"; MUTAGEN 317; /note="K->A: Induces a reduction in methyltransferase activity toward TAF10 but an increased methyltransferase activity for H3 and p53/TP53."; /evidence="ECO:0000269|PubMed:16415881
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
protein_family
SET7 subfamily
uniprot
proteins
pubmed
11214970
uniprot
proteins
pubmed
11779497
uniprot
proteins
pubmed
11850410
uniprot
proteins
pubmed
12372304
uniprot
proteins
pubmed
12389038
uniprot
proteins
pubmed
12514135
uniprot
proteins
pubmed
12540855
uniprot
proteins
pubmed
12588998
uniprot
proteins
pubmed
15099517
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15525938
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16141209
uniprot
proteins
pubmed
16415881
uniprot
proteins
pubmed
16433545
uniprot
proteins
pubmed
17108971
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27146893
uniprot
proteins
pubmed
35210392
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:11779497}. Chromosome {ECO:0000305|PubMed:11850410}.
uniprot
proteins