Cldn16
entrez
114141
canonical
uniprot
Q925N4
canonical
ensembl
ENSMUSG00000038148
resolver
ensp
ENSMUSP00000110957
resolver
ensp
ENSMUSP00000124528
resolver
enst
ENSMUST00000115302
resolver
enst
ENSMUST00000161053
resolver
genesymbol
Cldn16
resolver
uniprot
Q14BW2
resolver
uniprot
Q542L7
resolver
uniprot_entry
CLD16_MOUSE
resolver
uniprot_entry
Q14BW2_MOUSE
resolver
uniprot_sec
Q542L7
resolver
amino_acid_sequence
MKDLLQYAACFLAIFSTGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSIYAEHPLKLVVTRALMITADILAGFGFITLLLGLDCVKFLPDDPQIKVRLCFVAGTTLLIAGTPGIIGSVWYAVDVYVERSSLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGALLTCCLYLFKDVGPERNYPYAMRKPYSTAGVSMAKSYKAPRTETAKMYAVDTRV
uniprot
proteins
function
FUNCTION: Forms paracellular channels: coassembles with CLDN19 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (By similarity) (PubMed:28028216). Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption (PubMed:17442678, PubMed:28028216). {ECO:0000250|UniProtKB:Q9Y5I7, ECO:0000269|PubMed:17442678, ECO:0000269|PubMed:28028216}.
uniprot
proteins
mass_dalton
26100
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
11729235
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17442678
uniprot
proteins
pubmed
28028216
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:28028216}. Cell membrane {ECO:0000269|PubMed:28028216}; Multi-pass membrane protein {ECO:0000255}. Note=Cotrafficks with CLDN19 from ER to tight junctions. {ECO:0000250|UniProtKB:Q9Y5I7}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 80..100; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins