LILRB2
entrez
10288
canonical
uniprot
Q8N423
canonical
ensembl
ENSG00000131042
resolver
ensembl
ENSG00000274513
resolver
ensembl
ENSG00000275463
resolver
ensembl
ENSG00000276146
resolver
ensp
ENSP00000319960
resolver
ensp
ENSP00000375626
resolver
ensp
ENSP00000375628
resolver
ensp
ENSP00000375629
resolver
ensp
ENSP00000410117
resolver
ensp
ENSP00000480302
resolver
ensp
ENSP00000480841
resolver
ensp
ENSP00000481208
resolver
ensp
ENSP00000482933
resolver
ensp
ENSP00000483014
resolver
ensp
ENSP00000483478
resolver
ensp
ENSP00000483553
resolver
ensp
ENSP00000484373
resolver
ensp
ENSP00000677144
resolver
enst
ENST00000610886
resolver
enst
ENST00000614225
resolver
enst
ENST00000617341
resolver
enst
ENST00000617886
resolver
enst
ENST00000618392
resolver
enst
ENST00000618705
resolver
enst
ENST00000619122
resolver
enst
ENST00000621020
resolver
genesymbol
LILRB2
resolver
genesymbol_syn
ILT4
resolver
genesymbol_syn
LIR2
resolver
genesymbol_syn
MIR10
resolver
hgnc
HGNC:6606
resolver
uniprot
A2IXV5
resolver
uniprot
A8MU67
resolver
uniprot
C9JF29
resolver
uniprot
O75017
resolver
uniprot
Q8NHJ7
resolver
uniprot
Q8NHJ8
resolver
uniprot_entry
LIRB2_HUMAN
resolver
uniprot_sec
A2IXV5
resolver
uniprot_sec
A8MU67
resolver
uniprot_sec
C9JF29
resolver
uniprot_sec
O75017
resolver
uniprot_sec
Q8NHJ7
resolver
uniprot_sec
Q8NHJ8
resolver
amino_acid_sequence
MTPIVTVLICLGLSLGPRTRVQTGTIPKPTLWAEPDSVITQGSPVTLSCQGSLEAQEYRLYREKKSASWITRIRPELVKNGQFHIPSITWEHTGRYGCQYYSRARWSELSDPLVLVMTGAYPKPTLSAQPSPVVTSGGRVTLQCESQVAFGGFILCKEGEDEHPQCLNSQPHARGSSRAIFSVGPVSPNRRWSHRCYGYDLNSPYVWSSPSDLLELLVPGVSKKPSLSVQPGPVMAPGESLTLQCVSDVGYDRFVLYKEGERDLRQLPGRQPQAGLSQANFTLGPVSRSYGGQYRCYGAHNLSSECSAPSDPLDILITGQIRGTPFISVQPGPTVASGENVTLLCQSWRQFHTFLLTKAGAADAPLRLRSIHEYPKYQAEFPMSPVTSAHAGTYRCYGSLNSDPYLLSHPSEPLELVVSGPSMGSSPPPTGPISTPGPEDQPLTPTGSDPQSGLGRHLGVVIGILVAVVLLLLLLLLLFLILRHRRQGKHWTSTQRKADFQHPAGAVGPEPTDRGLQWRSSPAADAQEENLYAAVKDTQPEDGVEMDTRAAASEAPQDVTYAQLHSLTLRRKATEPPPSQEREPPAEPSIYATLAIH
uniprot
proteins
function
FUNCTION: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042). Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:16455647, PubMed:20448110, PubMed:27859042). Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885). {ECO:0000269|PubMed:11169396, ECO:0000269|PubMed:11875462, ECO:0000269|PubMed:12853576, ECO:0000269|PubMed:16455647, ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:27859042, ECO:0000269|PubMed:9548455, ECO:0000269|PubMed:9842885}.
uniprot
proteins
mass_dalton
65005
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. {ECO:0000269|PubMed:9842885}.
uniprot
proteins
pubmed
11169396
uniprot
proteins
pubmed
11875462
uniprot
proteins
pubmed
12390682
uniprot
proteins
pubmed
12853576
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16455647
uniprot
proteins
pubmed
19860908
uniprot
proteins
pubmed
20448110
uniprot
proteins
pubmed
27859042
uniprot
proteins
pubmed
9259559
uniprot
proteins
pubmed
9382880
uniprot
proteins
pubmed
9548455
uniprot
proteins
pubmed
9842885
uniprot
proteins
sequence_length
597
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20448110}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 461..481; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins