CCT7
entrez
10574
canonical
uniprot
Q99832
canonical
ensembl
ENSG00000135624
resolver
ensp
ENSP00000258091
resolver
ensp
ENSP00000381456
resolver
ensp
ENSP00000437824
resolver
ensp
ENSP00000442058
resolver
genesymbol
CCT7
resolver
genesymbol_syn
CCTH
resolver
genesymbol_syn
NIP7-1
resolver
hgnc
HGNC:1622
resolver
uniprot
A8K7E6
resolver
uniprot
A8MWI8
resolver
uniprot
B7WNW9
resolver
uniprot
B7Z4T9
resolver
uniprot
B7Z4Z7
resolver
uniprot
O14871
resolver
uniprot
Q6FI26
resolver
uniprot_entry
TCPH_HUMAN
resolver
uniprot_sec
A8K7E6
resolver
uniprot_sec
A8MWI8
resolver
uniprot_sec
B7WNW9
resolver
uniprot_sec
B7Z4T9
resolver
uniprot_sec
B7Z4Z7
resolver
uniprot_sec
O14871
resolver
uniprot_sec
Q6FI26
resolver
amino_acid_sequence
MMPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMMLDDLLQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGERYNFFTGCPKAKTCTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWYGVDINNEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRSTVDAPTAAGRGRGRGRPH
uniprot
proteins
disease_involvement
DISEASE: Note=De novo genetic variants in nearly every subunit of the TRiC complex, including CCT7, have been found in individuals with a broad spectrum of brain malformations, and clinical phenotypes ranging from mild to severe epilepsy, developmental delay, intellectual disability, ataxia, and other features of cerebral malfunction. {ECO:0000269|PubMed:39480921}.
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
function
FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
uniprot
proteins
mass_dalton
59367
uniprot
proteins
protein_family
TCP-1 chaperonin family
uniprot
proteins
pubmed
14532270
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25467444
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
33144677
uniprot
proteins
pubmed
35449234
uniprot
proteins
pubmed
36493755
uniprot
proteins
pubmed
37193829
uniprot
proteins
pubmed
39480921
uniprot
proteins
pubmed
9819444
uniprot
proteins
sequence_length
543
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P80313}.
uniprot
proteins