GOLGA1
entrez
2800
canonical
uniprot
Q92805
canonical
ensembl
ENSG00000136935
resolver
ensp
ENSP00000362656
resolver
ensp
ENSP00000546387
resolver
ensp
ENSP00000546388
resolver
ensp
ENSP00000546391
resolver
ensp
ENSP00000546392
resolver
ensp
ENSP00000598406
resolver
enst
ENST00000373555
resolver
enst
ENST00000876328
resolver
enst
ENST00000876329
resolver
enst
ENST00000876332
resolver
enst
ENST00000876333
resolver
enst
ENST00000928347
resolver
genesymbol
GOLGA1
resolver
hgnc
HGNC:4424
resolver
uniprot
Q5T164
resolver
uniprot
Q8IYZ9
resolver
uniprot_entry
GOGA1_HUMAN
resolver
uniprot_sec
Q5T164
resolver
uniprot_sec
Q8IYZ9
resolver
amino_acid_sequence
MFAKLKKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHLQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPDNELFEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLKHVVLKFMSCRESEAFHLIKAVSVLLNFSQEEENMLKETLEYKMSWFGSKPAPKGSIRPSISNPRIPWS
uniprot
proteins
function
FUNCTION: Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. Mechanistically, captures transport vesicles arriving from endosomes via the protein TBC1D23 (PubMed:29084197, PubMed:38552021). Recognized vesicles are then tethered to the trans-Golgi before subsequent SNARE engagement and vesicle fusion. Selectively regulates E-cadherin transport from the trans-Golgi network in tubulovesicular carriers (PubMed:34969853). {ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:34969853, ECO:0000269|PubMed:38552021}.; FUNCTION: (Microbial infection) Plays an important role in poxvirus morphogenesis. Translocates into the viral factories where it may transport the membrane fragments and associated protein factors important for virus maturation to the sites of virion assembly. {ECO:0000269|PubMed:17276477}.
uniprot
proteins
mass_dalton
88184
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="F->A: Loss of TBC1D23-binding."; /evidence="ECO:0000269|PubMed:29084197"; MUTAGEN 4; /note="K->A: No effect on TBC1D23-binding."; /evidence="ECO:0000269|PubMed:29084197"; MUTAGEN 5; /note="L->A: Loss of TBC1D23-binding."; /evidence="ECO:0000269|PubMed:29084197"; MUTAGEN 6; /note="K->A: Decreased TBC1D23-binding."; /evidence="ECO:0000269|PubMed:29084197"; MUTAGEN 7; /note="K->A: No effect on TBC1D23-binding."; /evidence="ECO:0000269|PubMed:29084197"; MUTAGEN 8; /note="K->A: No effect on TBC1D23-binding."; /evidence="ECO:0000269|PubMed:29084197"; MUTAGEN 9; /note="I->A: Decreased TBC1D23-binding."; /evidence="ECO:0000269|PubMed:29084197"; MUTAGEN 11; /note="E->A: No effect on TBC1D23-binding."; /evidence="ECO:0000269|PubMed:29084197"; MUTAGEN 12; /note="E->A: No effect on TBC1D23-binding."; /evidence="ECO:0000269|PubMed:29084197"; MUTAGEN 695; /note="F->A: No effect on RAB6A-binding, nor on targeting to the Golgi apparatus."; /evidence="ECO:0000269|PubMed:10209123"; MUTAGEN 696; /note="E->A: No effect on RAB6A-binding, nor on targeting to the Golgi apparatus."; /evidence="ECO:0000269|PubMed:10209123"; MUTAGEN 697; /note="Y->A: Loss of RAB6A-binding and of targeting to the Golgi apparatus."; /evidence="ECO:0000269|PubMed:10209123"; MUTAGEN 698; /note="L->A: No effect on RAB6A-binding, nor on targeting to the Golgi apparatus."; /evidence="ECO:0000269|PubMed:10209123"; MUTAGEN 742; /note="M->A: No effect on subcellular localization at the Golgi apparatus."; /evidence="ECO:0000269|PubMed:10209123"; MUTAGEN 743; /note="S->A: No effect on subcellular localization at the Golgi apparatus, small decrease in RAB6A-binding."; /evidence="ECO:0000269|PubMed:10209123"; MUTAGEN 744; /note="W->A: Drastically reduced targeting to the Golgi apparatus, small decrease in RAB6A-binding."; /evidence="ECO:0000269|PubMed:10209123
uniprot
proteins
post_translational_modification
PTM: MARylated by PARP12; MARylation is required for basolateral export of E-Cadherin. {ECO:0000269|PubMed:34969853}.
uniprot
proteins
pubmed
10209123
uniprot
proteins
pubmed
10209125
uniprot
proteins
pubmed
12972563
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17276477
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29084197
uniprot
proteins
pubmed
34969853
uniprot
proteins
pubmed
38552021
uniprot
proteins
pubmed
9324025
uniprot
proteins
sequence_length
767
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:10209123, ECO:0000269|PubMed:10209125, ECO:0000269|PubMed:12972563, ECO:0000269|PubMed:9324025}; Peripheral membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:17276477, ECO:0000269|PubMed:29084197}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9CW79}.
uniprot
proteins