RAB11FIP2
entrez
22841
canonical
uniprot
Q7L804
canonical
ensembl
ENSG00000107560
resolver
ensp
ENSP00000347839
resolver
ensp
ENSP00000358200
resolver
genesymbol
RAB11FIP2
resolver
genesymbol_syn
KIAA0941
resolver
hgnc
HGNC:29152
resolver
uniprot
A6NEI4
resolver
uniprot
Q3I768
resolver
uniprot
Q9Y2F0
resolver
uniprot_entry
RFIP2_HUMAN
resolver
uniprot_sec
A6NEI4
resolver
uniprot_sec
Q3I768
resolver
uniprot_sec
Q9Y2F0
resolver
amino_acid_sequence
MMLSEQAQKWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIKNRGEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKGRKNDGTFSDTSSAIIPSTHMPDANSEFSSGEIQMKSKPKKPFLLGPQRLSSAHSMSDLSGSHMSSEKLKAGTIGQTHLLGHQLDSFGTVPESGSLKSPHRRTLSFDTSKMNQPDSIVDEGELCFGRQNDPFTNVTASLPQKFATLPRKKNPFEESSETWDSSMNLFSKPIEIRKENKREKREKVSLFERVTGKKDSRRSDKLNNGGSDSPCDLKSPNAFSENRQDYFDYESTNPFTAKFRASNIMPSSSFHMSPTSNEDLRKIPDSNPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDYIDNLLVRVMEETPSILRVPYEPSRKAGKFSNS
uniprot
proteins
function
FUNCTION: A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:30883606}.
uniprot
proteins
mass_dalton
58279
uniprot
proteins
mutagenesis
MUTAGEN 223; /note="S->A: No effect."; /evidence="ECO:0000269|PubMed:16775013"; MUTAGEN 224; /note="S->A: No effect."; /evidence="ECO:0000269|PubMed:16775013"; MUTAGEN 227; /note="S->A: Abolishes phosphorylation by MARK2 and induces defects in the reestablishment of junctional complexes."; /evidence="ECO:0000269|PubMed:16775013"; MUTAGEN 229; /note="S->A: No effect."; /evidence="ECO:0000269|PubMed:16775013"; MUTAGEN 406..408; /note="NPF->AAA: Severe reduction of the interaction with REPS1 and AP2A1. No effects on its subcellular location. Modifies the endocytosis activity."; /evidence="ECO:0000269|PubMed:12364336"; MUTAGEN 480..482; /note="YID->AAA: Abolishes the interaction with REPS1 and AP2A1. Modifies its subcellular location and the endocytosis activity. Enhances homooligomerization."; /evidence="ECO:0000269|PubMed:12364336"; MUTAGEN 480; /note="Y->F: No effect on the interaction with RAB11A. Abolishes the vesicular localization."; /evidence="ECO:0000269|PubMed:16905101"; MUTAGEN 481; /note="I->E: Abolishes the interaction with RAB11A and the vesicular localization."; /evidence="ECO:0000269|PubMed:16905101
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity. {ECO:0000269|PubMed:16775013}.
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
11495908
uniprot
proteins
pubmed
11944901
uniprot
proteins
pubmed
11994279
uniprot
proteins
pubmed
12364336
uniprot
proteins
pubmed
12470645
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15173169
uniprot
proteins
pubmed
15304524
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16251358
uniprot
proteins
pubmed
16775013
uniprot
proteins
pubmed
16905101
uniprot
proteins
pubmed
19542231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26032412
uniprot
proteins
pubmed
30883606
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, phagocytic cup {ECO:0000269|PubMed:30883606}. Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.
uniprot
proteins