TEN1
entrez
100134934
canonical
uniprot
Q86WV5
canonical
ensembl
ENSG00000257949
resolver
ensembl
ENSG00000261408
resolver
ensp
ENSP00000380762
resolver
ensp
ENSP00000497034
resolver
ensp
ENSP00000581234
resolver
ensp
ENSP00000581235
resolver
ensp
ENSP00000581236
resolver
ensp
ENSP00000610473
resolver
ensp
ENSP00000610474
resolver
ensp
ENSP00000627786
resolver
ensp
ENSP00000627787
resolver
enst
ENST00000397640
resolver
enst
ENST00000649294
resolver
enst
ENST00000911175
resolver
enst
ENST00000911176
resolver
enst
ENST00000911177
resolver
enst
ENST00000940414
resolver
enst
ENST00000940415
resolver
enst
ENST00000957727
resolver
enst
ENST00000957728
resolver
genesymbol
TEN1
resolver
genesymbol_syn
C17orf106
resolver
hgnc
HGNC:37242
resolver
uniprot
I3L0C7
resolver
uniprot_entry
TEN1L_HUMAN
resolver
uniprot_sec
I3L0C7
resolver
amino_acid_sequence
MMLPKPGTYYLPWEVSAGQVPDGSTLRTFGRLCLYDMIQSRVTLMAQHGSDQHQVLVCTKLVEPFHAQVGSLYIVLGELQHQQDRGSVVKARVLTCVEGMNLPLLEQAIREQRLYKQERGGSQ
uniprot
proteins
function
FUNCTION: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097). {ECO:0000269|PubMed:19854130, ECO:0000269|PubMed:22763445, ECO:0000269|PubMed:25483097}.
uniprot
proteins
mass_dalton
13856
uniprot
proteins
mutagenesis
MUTAGEN 115; /note="Y->A: 2.5-fold reduction in binding affinity for STN1."; /evidence="ECO:0000269|PubMed:23826127"; MUTAGEN 119; /note="R->Q: 2-fold reduction in binding affinity for STN1."; /evidence="ECO:0000269|PubMed:23826127
uniprot
proteins
protein_family
TEN1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19854130
uniprot
proteins
pubmed
22763445
uniprot
proteins
pubmed
22863775
uniprot
proteins
pubmed
23826127
uniprot
proteins
pubmed
25483097
uniprot
proteins
sequence_length
123
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19854130}. Chromosome, telomere {ECO:0000269|PubMed:19854130}.
uniprot
proteins