Tekt3
entrez
287392
canonical
uniprot
Q4V8G8
canonical
ensembl
ENSRNOG00000027212
resolver
ensembl
ENSRNOG00055030996
resolver
ensembl
ENSRNOG00060021776
resolver
ensembl
ENSRNOG00065008125
resolver
ensp
ENSRNOP00000031637
resolver
ensp
ENSRNOP00055044481
resolver
ensp
ENSRNOP00060031116
resolver
ensp
ENSRNOP00065009458
resolver
enst
ENSRNOT00000038276
resolver
enst
ENSRNOT00055053763
resolver
enst
ENSRNOT00060037724
resolver
enst
ENSRNOT00065012857
resolver
genesymbol
Tekt3
resolver
uniprot_entry
TEKT3_RAT
resolver
amino_acid_sequence
MEPLGSTLTATYAHPQPAATNFLPAIGTLTSSYRNRFPHRNLTHSLSLPWRPSTYYKTAYNYPTLAPLSSTSQSVCESTMLPFVSNRTTLFTRYTPDDWYRSTLVGFQESNCSRHNSERLRVDTSRLIQDKYQQIRKTQADSTQNLGERVNDIAFWKSEIIHELDEMIGETNALTDIKRRLERGLIETDAPLQVARECLFHREKRMGIDLVHDEAEKELLTEVETVLCCQERMRRHLDKAIAQLASDRSAQHELEKDLSDKQAALRIDDKCKHLRNTSQGVSYFRGVENVDATVSVPESWAKFTDDNVLRSQSERAASAKLREDTENLLIVIANEMWNQFNKVNVAFTNRIAETVDAKNKIHIHLSKTLQEIFQTEMAIESIRKAIKEKSAFLKVAQTRLDERTRRPNIELCRDIAQLRLVNEVYEVDETIQTLQQRLRDSEDTLQSLAHTKATLEHDLAVKANTLYIDQEKCMSMRNSYPSTLRLVGFC
uniprot
proteins
function
FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Required for normal sperm mobility (By similarity). {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q6X6Z7}.
uniprot
proteins
mass_dalton
56416
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated. {ECO:0000250|UniProtKB:A6H782}.; PTM: May be proteolytically processed during the epididymal transit of spermatozoa. {ECO:0000250|UniProtKB:A6H782}.; PTM: Ubiquitinated, leading to its degradation. Deubiquitinated by USP16, promoting its stability. {ECO:0000250|UniProtKB:Q6X6Z7}.
uniprot
proteins
protein_family
Tektin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19423663
uniprot
proteins
pubmed
21744413
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A6H782}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:19423663, ECO:0000269|PubMed:21744413}. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane {ECO:0000269|PubMed:21744413}; Peripheral membrane protein {ECO:0000305}. Note=In spermatozoa, preferentially localizes to the flagella, but also found in the head (By similarity). In the sperm flagellum, localizes to the periaxonemal region where it associates with the mitochondrial sheath and outer dense fibers (PubMed:21744413). Not detected in the central axonemal region of the flagellum (PubMed:21744413). Associates with the acrosome membrane in the equatorial segment of the sperm head (PubMed:21744413). Also detected just below the plasma membrane in the post-acrosomal region where it might localize to the postacrosomal dense lamina (By similarity). However, other studies report little or no expression in the postacrosomal region (PubMed:21744413). Translocates from the postacrosomal region to the equatorial segment after sperm activation (By similarity). Retained in the postacromal region, but not the equatorial segment, following the acrosome reaction (By similarity). Some studies report strong expression in the anterior cap region (By similarity). However, other studies report little or no expression in the acrosomal cap (By similarity). {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q9BXF9, ECO:0000269|PubMed:21744413}.
uniprot
proteins