Ap2s1
entrez
65046
canonical
uniprot
P62744
canonical
ensembl
ENSRNOG00000015865
resolver
ensembl
ENSRNOG00055030844
resolver
ensembl
ENSRNOG00060021554
resolver
ensembl
ENSRNOG00065031779
resolver
ensp
ENSRNOP00000021310
resolver
ensp
ENSRNOP00055044270
resolver
ensp
ENSRNOP00060030903
resolver
ensp
ENSRNOP00065045047
resolver
enst
ENSRNOT00055053545
resolver
enst
ENSRNOT00060037498
resolver
enst
ENSRNOT00065054781
resolver
genesymbol
Ap2s1
resolver
genesymbol_syn
Ap17
resolver
genesymbol_syn
Claps2
resolver
uniprot
P70626
resolver
uniprot
P97626
resolver
uniprot
Q00380
resolver
uniprot_entry
AP2S1_RAT
resolver
uniprot_sec
P70626
resolver
uniprot_sec
P97626
resolver
uniprot_sec
Q00380
resolver
amino_acid_sequence
MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYRRYAGLYFCICVDVNDNNLAYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVLKQLLMLQSLE
uniprot
proteins
function
FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. May also play a role in extracellular calcium homeostasis (By similarity). {ECO:0000250, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838}.
uniprot
proteins
mass_dalton
17018
uniprot
proteins
protein_family
Adaptor complexes small subunit family
uniprot
proteins
pubmed
10559001
uniprot
proteins
pubmed
14745134
uniprot
proteins
pubmed
15473838
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2040623
uniprot
proteins
sequence_length
142
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P63010}. Membrane, coated pit {ECO:0000250|UniProtKB:P53680}; Peripheral membrane protein {ECO:0000250|UniProtKB:P53680}; Cytoplasmic side {ECO:0000250|UniProtKB:P53680}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250|UniProtKB:P63010}.
uniprot
proteins