PLEKHM2
entrez
23207
canonical
uniprot
Q8IWE5
canonical
ensembl
ENSG00000116786
resolver
ensp
ENSP00000364950
resolver
ensp
ENSP00000364956
resolver
ensp
ENSP00000520968
resolver
enst
ENST00000850891
resolver
genesymbol
PLEKHM2
resolver
genesymbol_syn
KIAA0842
resolver
genesymbol_syn
SKIP
resolver
hgnc
HGNC:29131
resolver
uniprot
A0ABJ7H8D0
resolver
uniprot
O94928
resolver
uniprot
Q5VT65
resolver
uniprot
Q5VVD7
resolver
uniprot
Q6NUH9
resolver
uniprot
Q7L8G1
resolver
uniprot
Q8IVT7
resolver
uniprot
Q8N2T4
resolver
uniprot
Q96AY0
resolver
uniprot
Q9NTF7
resolver
uniprot_entry
A0ABJ7H8D0_HUMAN
resolver
uniprot_entry
PKHM2_HUMAN
resolver
uniprot_sec
O94928
resolver
uniprot_sec
Q5VT65
resolver
uniprot_sec
Q5VVD7
resolver
uniprot_sec
Q6NUH9
resolver
uniprot_sec
Q7L8G1
resolver
uniprot_sec
Q8IVT7
resolver
uniprot_sec
Q8N2T4
resolver
uniprot_sec
Q96AY0
resolver
uniprot_sec
Q9NTF7
resolver
amino_acid_sequence
MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDLSSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGDLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGGHHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPVSEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATMEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEGTITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPHAFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFTCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELDRLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC
uniprot
proteins
function
FUNCTION: Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:28325809}.
uniprot
proteins
mass_dalton
112780
uniprot
proteins
mutagenesis
MUTAGEN 207..208; /note="WD->AA: No effect on lysosomal location; loss of interaction with kinesin-1 and movement of lysosomes to the periphery; when associated with A-236-237-A."; /evidence="ECO:0000269|PubMed:22172677"; MUTAGEN 236..237; /note="WE->AA: No effect on lysosomal location; loss of interaction with kinesin-1 and movement of lysosomes to the periphery; when associated with A-207-208-A."; /evidence="ECO:0000269|PubMed:22172677"; MUTAGEN 828; /note="G->D: Loss of interaction with sifA."; /evidence="ECO:0000269|PubMed:18996344"; MUTAGEN 830; /note="R->D: Loss of interaction with sifA."; /evidence="ECO:0000269|PubMed:18996344"; MUTAGEN 831; /note="R->A: Alters interaction with sifA."; /evidence="ECO:0000269|PubMed:18996344"; MUTAGEN 869; /note="C->D: Loss of interaction with sifA."; /evidence="ECO:0000269|PubMed:18996344
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15905402
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18996344
uniprot
proteins
pubmed
22172677
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24088571
uniprot
proteins
pubmed
25898167
uniprot
proteins
pubmed
28325809
uniprot
proteins
sequence_length
1019
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15905402}. Lysosome membrane {ECO:0000269|PubMed:22172677}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305|PubMed:22172677}.
uniprot
proteins