Ssna1
entrez
68475
canonical
uniprot
Q9JJ94
canonical
ensembl
ENSMUSG00000026966
resolver
ensp
ENSMUSP00000028342
resolver
enst
ENSMUST00000028342
resolver
genesymbol
Ssna1
resolver
uniprot_entry
SSNA1_MOUSE
resolver
amino_acid_sequence
MTQQGAALQNYNNELVKCIEELCQKREELCRQIQQEEDEKQRLQNEVRQLTEKLARVNENLARKIASRNEFDRTIAETEAAYLKILESSQTLLSVLKREAGNLTKATASDQKSSGGKDS
uniprot
proteins
function
FUNCTION: Microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage, protecting microtubules from the microtubule-severing enzyme SPAST (By similarity). Induces microtubule branching which is mediated by the formation of long SSNA1 fibrils which guide microtubule protofilaments to split apart from the mother microtubule and form daughter microtubules (By similarity). Plays a role in axon outgrowth and branching (PubMed:30250060). Required for cell division (By similarity). {ECO:0000250|UniProtKB:O43805, ECO:0000250|UniProtKB:Q9XF62, ECO:0000269|PubMed:30250060}.
uniprot
proteins
mass_dalton
13557
uniprot
proteins
protein_family
SSNA1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30250060
uniprot
proteins
sequence_length
119
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43805}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O43805}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:O43805}. Midbody {ECO:0000250|UniProtKB:O43805}. Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000250|UniProtKB:O43805}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:O43805}. Cell projection, axon {ECO:0000269|PubMed:30250060}. Note=In sperm, strongly expressed in the basal body region with weaker expression in the axoneme (By similarity). Localizes to axon branching points in neurons (PubMed:30250060). {ECO:0000250|UniProtKB:O43805, ECO:0000269|PubMed:30250060}.
uniprot
proteins