GPSM1
entrez
26086
canonical
uniprot
Q86YR5
canonical
ensembl
ENSG00000160360
resolver
ensp
ENSP00000376673
resolver
ensp
ENSP00000390705
resolver
ensp
ENSP00000392828
resolver
ensp
ENSP00000479405
resolver
enst
ENST00000440944
resolver
enst
ENST00000616132
resolver
genesymbol
GPSM1
resolver
genesymbol_syn
AGS3
resolver
hgnc
HGNC:17858
resolver
uniprot
A0A087WVF5
resolver
uniprot
A0A0A0MSK4
resolver
uniprot
A9Z1X4
resolver
uniprot
B1B0W3
resolver
uniprot
Q86SR5
resolver
uniprot
Q969T1
resolver
uniprot
Q9UFS8
resolver
uniprot_entry
A0A087WVF5_HUMAN
resolver
uniprot_entry
A0A0A0MSK4_HUMAN
resolver
uniprot_entry
GPSM1_HUMAN
resolver
uniprot_sec
A9Z1X4
resolver
uniprot_sec
B1B0W3
resolver
uniprot_sec
Q86SR5
resolver
uniprot_sec
Q969T1
resolver
uniprot_sec
Q9UFS8
resolver
amino_acid_sequence
MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLEREQNGDSHHSGDWRGPSRDSLPLPVRSRKYQEGPDAERRPREGSHSPLDSADVRVHVPRTSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQSSRIDDQRCPPPDVLPRGPTMPDEDFFSLIQRVQAKRMDEQRVDLAGGPEQGAGGPPEPQQQCQPGAS
uniprot
proteins
function
FUNCTION: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269|PubMed:11024022, ECO:0000269|PubMed:12642577}.
uniprot
proteins
mass_dalton
74510
uniprot
proteins
post_translational_modification
PTM: Phosphorylation regulates interaction with G(i/o) alpha. {ECO:0000250}.
uniprot
proteins
protein_family
GPSM family
uniprot
proteins
pubmed
11024022
uniprot
proteins
pubmed
12642577
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16458856
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18566450
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
675
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
uniprot
proteins