CREB3L3
entrez
84699
canonical
uniprot
Q68CJ9
canonical
ensembl
ENSG00000060566
resolver
ensp
ENSP00000078445
resolver
ensp
ENSP00000469355
resolver
ensp
ENSP00000470119
resolver
ensp
ENSP00000472399
resolver
genesymbol
CREB3L3
resolver
genesymbol_syn
CREBH
resolver
hgnc
HGNC:18855
resolver
uniprot
B2R7S6
resolver
uniprot
B7ZL69
resolver
uniprot
M0QYW7
resolver
uniprot
Q6ZMC5
resolver
uniprot
Q96TB9
resolver
uniprot_entry
CR3L3_HUMAN
resolver
uniprot_sec
B2R7S6
resolver
uniprot_sec
B7ZL69
resolver
uniprot_sec
M0QYW7
resolver
uniprot_sec
Q6ZMC5
resolver
uniprot_sec
Q96TB9
resolver
amino_acid_sequence
MNTDLAAGKMASAACSMDPIDSFELLDLLFDRQDGILRHVELGEGWGHVKDQQVLPNPDSDDFLSSILGSGDSLPSSPLWSPEGSDSGISEDLPSDPQDTPPRSGPATSPAGCHPAQPGKGPCLSYHPGNSCSTTTPGPVIQVPEASVTIDLEMWSPGGRICAEKPADPVDLSPRCNLTVKDLLLSGSSGDLQQHHLGASYLLRPGAGHCQELVLTEDEKKLLAKEGITLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNLSLLEQLKKLQAIVVQSTSKSAQTGTCVAVLLLSFALIILPSISPFGPNKTESPGDFAPVRVFSRTLHNDAASRVAADAVPGSEAPGPRPEADTTREESPGSPGADWGFQDTANLTNSTEELDNATLVLRNATEGLGQVALLDWVAPGPSTGSGRAGLEAAGDEL
uniprot
proteins
disease_involvement
DISEASE: Hypertriglyceridemia 2 (HYTG2) [MIM:619324]: An autosomal dominant form of hypertriglyceridemia, a disorder characterized by elevated plasma triglyceride levels. HYTG2 patients also have increased total cholesterol levels and low levels of high density lipoprotein (HDL) cholesterol. Reduced penetrance has been observed. {ECO:0000269|PubMed:21666694, ECO:0000269|PubMed:26427795}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription (By similarity). Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations (PubMed:21666694). {ECO:0000250, ECO:0000250|UniProtKB:Q91XE9, ECO:0000269|PubMed:11353085, ECO:0000269|PubMed:15800215, ECO:0000269|PubMed:16469704, ECO:0000269|PubMed:21666694}.
uniprot
proteins
mass_dalton
49077
uniprot
proteins
mutagenesis
MUTAGEN 294; /note="K->R: Loss of ubiquitination by SYNV1/HRD1."; /evidence="ECO:0000269|PubMed:30389664"; MUTAGEN 361; /note="R->A: Decreases proteolytic cleavage upon ER stress."; /evidence="ECO:0000269|PubMed:16469704
uniprot
proteins
post_translational_modification
PTM: Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). {ECO:0000269|PubMed:16469704}.; PTM: N- and O-glycosylated. N-glycosylation is required for optimal proteolytic activation. O-glycosylated with core 1 or possibly core 8 glycans. {ECO:0000269|PubMed:20356926, ECO:0000269|PubMed:22171320}.; PTM: Ubiquitinated at Lys-294 by SYNV1/HRD1 via 'Lys-27'-linked ubiquitin. {ECO:0000269|PubMed:30389664}.
uniprot
proteins
protein_family
ATF subfamily
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
11353085
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15221005
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15800215
uniprot
proteins
pubmed
16469704
uniprot
proteins
pubmed
20356926
uniprot
proteins
pubmed
21666694
uniprot
proteins
pubmed
22171320
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26427795
uniprot
proteins
pubmed
30389664
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11353085}; Single-pass type II membrane protein {ECO:0000269|PubMed:11353085}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 3]: Nucleus {ECO:0000269|PubMed:30389664}. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
uniprot
proteins
transmembrane_region
TRANSMEM 323..343; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins