Ago4
entrez
76850
canonical
uniprot
Q8CJF8
canonical
ensembl
ENSMUSG00000042500
resolver
ensp
ENSMUSP00000081312
resolver
ensp
ENSMUSP00000230571
resolver
genesymbol
Ago4
resolver
genesymbol_syn
Eif2c4
resolver
genesymbol_syn
Kiaa1567
resolver
uniprot
Q4VBD7
resolver
uniprot
Q6ZPM6
resolver
uniprot
Q8BTF4
resolver
uniprot
Q9CS58
resolver
uniprot_entry
AGO4_MOUSE
resolver
uniprot_entry
Q9CS58_MOUSE
resolver
uniprot_sec
Q4VBD7
resolver
uniprot_sec
Q6ZPM6
resolver
uniprot_sec
Q8BTF4
resolver
amino_acid_sequence
MEALGPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRIDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKHPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPSQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKMNAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEITQELLYSQEVVQDLTSMARELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKMERVGKSGNVPAGTTVDSTVTHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA
uniprot
proteins
function
FUNCTION: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. {ECO:0000255|HAMAP-Rule:MF_03033, ECO:0000269|PubMed:19174539}.
uniprot
proteins
mass_dalton
97037
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated on surface-exposed lysines by a SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 during target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs). Ubiquitination by the SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 leads to its subsequent degradation, thereby exposing miRNAs for degradation. ZSWIM8 recognizes and binds AGO4 when it is engaged with a TDMD target. {ECO:0000250|UniProtKB:Q9UKV8}.
uniprot
proteins
protein_family
Ago subfamily
uniprot
proteins
protein_family
Argonaute family
uniprot
proteins
pubmed
12526743
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19174539
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
861
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000255|HAMAP-Rule:MF_03033}.
uniprot
proteins