Mmp17
entrez
23948
canonical
uniprot
Q9R0S3
canonical
ensembl
ENSMUSG00000029436
resolver
ensp
ENSMUSP00000031390
resolver
enst
ENSMUST00000031390
resolver
genesymbol
Mmp17
resolver
genesymbol_syn
Mt4mmp
resolver
uniprot
Q80UM9
resolver
uniprot_entry
MMP17_MOUSE
resolver
uniprot_sec
Q80UM9
resolver
amino_acid_sequence
MGRRPRGPGSPRGPGPPRPGPGLPPLLLVLALAAHGGCAAPAPRAEDLSLGVEWLSRFGYLPPADPASGQLQTQEELSKAITAMQQFGGLETTGILDEATLALMKTPRCSLPDLPPGAQSRRKRQTPPPTKWSKRNLSWRVRTFPRDSPLGRDTVRALMYYALKVWSDITPLNFHEVAGNAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGDHHTAGDTHFDDDEPWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAPSSIMQPYYQGPVGDPLRYGLPYEDRVRVWQLYGVRESVSPTAQLDTPEPEEPPLLPEPPNNRSSTPPQKDVPHRCTAHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAVFSWAHNDRTYFFKDQLYWRYDDHTRRMDPGYPAQGPLWRGVPSMLDDAMRWSDGASYFFRGQEYWKVLDGELEAAPGYPQSTARDWLVCGEPLADAEDVGPGPQGRSGAQDGLAVCSCTSDAHRLALPSLLLLTPLLWGL
uniprot
proteins
ec_number
3.4.24.-
uniprot
proteins
function
FUNCTION: Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin. {ECO:0000269|PubMed:10799478}.
uniprot
proteins
mass_dalton
64333
uniprot
proteins
mutagenesis
MUTAGEN 248; /note="E->A: Loss of activity."; /evidence="ECO:0000269|PubMed:10567400
uniprot
proteins
post_translational_modification
PTM: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.
uniprot
proteins
protein_family
Peptidase M10A family
uniprot
proteins
pubmed
10471807
uniprot
proteins
pubmed
10567400
uniprot
proteins
pubmed
10799478
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
578
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.
uniprot
proteins