Rab27b
entrez
80718
canonical
uniprot
Q99P58
canonical
ensembl
ENSMUSG00000024511
resolver
ensp
ENSMUSP00000068349
resolver
ensp
ENSMUSP00000112807
resolver
ensp
ENSMUSP00000114094
resolver
enst
ENSMUST00000069749
resolver
enst
ENSMUST00000117692
resolver
enst
ENSMUST00000121693
resolver
genesymbol
Rab27b
resolver
genesymbol_syn
Rab27B
resolver
genesymbol_syn
rab27b
resolver
uniprot
Q05D38
resolver
uniprot
Q549X4
resolver
uniprot
Q8CIX0
resolver
uniprot_entry
Q05D38_MOUSE
resolver
uniprot_entry
Q549X4_MOUSE
resolver
uniprot_entry
RB27B_MOUSE
resolver
uniprot_sec
Q8CIX0
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including DENND10, which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:O00194}.
uniprot
proteins
amino_acid_sequence
MTDGDYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYDTQGADGASGKAFKVHLQLWDTAGQERFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCENPDIVLIGNKADLPDQREVNERQARELAEKYGIPYFETSAATGQNVEKSVETLLDLIMKRMEKCVEKTQVPDTVNGGNSGKLDGEKPAEKKCAC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB27B regulates homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to urothelial apical membranes (By similarity). {ECO:0000250|UniProtKB:O00194, ECO:0000250|UniProtKB:Q8HZJ5}.
uniprot
proteins
mass_dalton
24560
uniprot
proteins
mutagenesis
MUTAGEN 6; /note="Y->F: Abolishes the interaction with MLPH."; /evidence="ECO:0000269|PubMed:18940604"; MUTAGEN 78; /note="Q->L: Loss of GTPase activity."; /evidence="ECO:0000269|PubMed:18940604"; MUTAGEN 91; /note="D->G: Strongly reduces the interaction with MLPH."; /evidence="ECO:0000269|PubMed:18940604
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11178108
uniprot
proteins
pubmed
11956164
uniprot
proteins
pubmed
12221080
uniprot
proteins
pubmed
12578829
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16716193
uniprot
proteins
pubmed
18940604
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:O00194}; Lipid-anchor {ECO:0000250|UniProtKB:O00194}. Late endosome {ECO:0000250|UniProtKB:O00194}.
uniprot
proteins