TRABD2A
entrez
129293
canonical
uniprot
Q86V40
canonical
ensembl
ENSG00000186854
resolver
ensp
ENSP00000335004
resolver
ensp
ENSP00000387075
resolver
ensp
ENSP00000387183
resolver
ensp
ENSP00000689365
resolver
enst
ENST00000409133
resolver
genesymbol
TRABD2A
resolver
genesymbol_syn
C2orf89
resolver
genesymbol_syn
TIKI1
resolver
hgnc
HGNC:27013
resolver
uniprot
B4DKK8
resolver
uniprot
C9IYB5
resolver
uniprot
I6UMB9
resolver
uniprot_entry
C9IYB5_HUMAN
resolver
uniprot_entry
TIKI1_HUMAN
resolver
uniprot_sec
B4DKK8
resolver
uniprot_sec
I6UMB9
resolver
amino_acid_sequence
MSPWSWFLLQTLCLLPTGAASRRGAPGTANCELKPQQSELNSFLWTIKRDPPSYFFGTIHVPYTRVWDFIPDNSKEAFLQSSIVYFELDLTDPYTISALTSCQMLPQGENLQDVLPRDIYCRLKRHLEYVKLMMPLWMTPDQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTEVDIKSRGVPVLDLFLAQEAERLRKQTGAVEKVEEQCHPLNGLNFSQVIFALNQTLLQQESLRAGSLQIPYTTEDLIKHYNCGDLSSVILSHDSSQVPNFINATLPPQERITAQEIDSYLRRELIYKRNERIGKRVKALLEEFPDKGFFFAFGAGHFMGNNTVLDVLRREGYEVEHAPAGRPIHKGKSKKTSTRPTLSTIFAPKVPTLEVPAPEAVSSGHSTLPPLVSRPGSADTPSEAEQRFRKKRRRSQRRPRLRQFSDLWVRLEESDIVPQLQVPVLDRHISTELRLPRRGHSHHSQMVASSACLSLWTPVFWVLVLAFQTETPLL
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. {ECO:0000269|PubMed:22726442, ECO:0000269|PubMed:35182431}.
uniprot
proteins
mass_dalton
57676
uniprot
proteins
post_translational_modification
PTM: Attached to the external leaflet of the plasma membrane and enriched in membrane rafts via a GPI anchor. The GPI anchor can be cleaved by GDPD4/GDE6 and GDPD2/GDE3, releasing the protein from membranes. {ECO:0000269|PubMed:35182431}.
uniprot
proteins
protein_family
TIKI family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
22726442
uniprot
proteins
pubmed
35182431
uniprot
proteins
sequence_length
505
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22726442, ECO:0000269|PubMed:35182431}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:35182431}. Membrane raft {ECO:0000269|PubMed:22726442}.
uniprot
proteins