Angel2
entrez
52477
canonical
uniprot
Q8K1C0
canonical
ensembl
ENSMUSG00000026634
resolver
ensp
ENSMUSP00000027947
resolver
ensp
ENSMUSP00000064556
resolver
ensp
ENSMUSP00000106524
resolver
genesymbol
Angel2
resolver
genesymbol_syn
D1Ertd396e
resolver
genesymbol_syn
D1Ertd654e
resolver
uniprot
Q3TEH1
resolver
uniprot
Q3TL94
resolver
uniprot
Q8BTT0
resolver
uniprot
Q9JJB0
resolver
uniprot_entry
ANGE2_MOUSE
resolver
uniprot_sec
Q3TEH1
resolver
uniprot_sec
Q3TL94
resolver
uniprot_sec
Q8BTT0
resolver
uniprot_sec
Q9JJB0
resolver
amino_acid_sequence
METWRCVRRGYGRCVAGRGRYSMFPYPLKSLGRDWTTPWEDLQKYCWRRHISSCLRWPGHYSRAPYPYFSSRHFSLNCRPPFLFESGTQFQYYNWRSDHLSNASLIHLSRHVMTSDRDEPLSKRRKHQGTIKRNWEYLCSHNKENTKDLEDRNVDSTCEDREDKFDFSVMSYNILSQDLLEDNSHLYRHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDHYGTEIRPSLESLGYHCEYKMKTGRKPDGCAICFKHSRFSLLSVNPVEFCRRDIPLLDRDNIGLVLLLQPKIPRAASPSICIANTHLLYNPRRGDIKLTQLAMLLAEIANVTHRKDGSSCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLAIGKVSGQEQSSRGQRILSIPIWPPNLGISQNCVYEAQQVPKVEKTDSDVTQAQQEKAEVPVSADKVSSHLQHGFSLSSVYSHYVPDTGVPEVTTCHSRSAITVDYIFYTAKKENTAQGPGAEVALVGGLKLLARLSLLTEQDLWTVNGLPNEHNSSDHLPLLAKFRLEL
uniprot
proteins
ec_number
3.-.-.-
uniprot
proteins
function
FUNCTION: RNA 2',3'-cyclic phosphatase that catalyzes the hydrolysis of RNA molecules with a 2',3'-cyclic phosphate at the 3' end to produce RNA with a linear 3'-phosphate group (PubMed:36180430). Essential for the maturation and processing of mitochondrial RNAs, particularly those generated via non-canonical pathways (PubMed:36180430). Antagonizes pre-tRNA processing and XBP1 mRNA splicing during the unfolded protein response by limiting the availability of 2',3'-cyclic phosphate substrates for the tRNA ligase complex (By similarity). Promotes tRNA recycling by eliminating 2',3'-cyclic phosphate groups from cleaved tRNAs, thereby enabling the tRNA nucleotidyltransferase TRNT1 to reattach the CCA tail essential for aminoacylation and subsequent translation (By similarity). {ECO:0000250|UniProtKB:Q5VTE6, ECO:0000269|PubMed:36180430}.
uniprot
proteins
mass_dalton
62413
uniprot
proteins
protein_family
CCR4/nocturin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36180430
uniprot
proteins
sequence_length
544
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q5VTE6}.
uniprot
proteins