Exo5
entrez
73172
canonical
uniprot
Q9CXP9
canonical
ensembl
ENSMUSG00000028629
resolver
ensp
ENSMUSP00000030375
resolver
ensp
ENSMUSP00000136408
resolver
enst
ENSMUST00000030375
resolver
enst
ENSMUST00000177880
resolver
genesymbol
Exo5
resolver
genesymbol_syn
Dem1
resolver
uniprot
A2A767
resolver
uniprot
A2A769
resolver
uniprot_entry
EXO5_MOUSE
resolver
uniprot_sec
A2A767
resolver
uniprot_sec
A2A769
resolver
amino_acid_sequence
MAETGEEETASAEASGFSDLSDSELVEFLDLEEAKESAVSLSKPGPSAELPGKDDKPVSLQNWKGGLDVLSPMERFHLKYLYVTDLCTQNWCELQMVYGKELPGSLTPEKAAVLDTGASIHLAKELELHDLVTVPIATKEDAWAVKFLNILAMIPALQSEGRVREFPVFGEVEGIFLVGVIDELHYTSKGELELAELKTRRRPVLPLPAQKKKDYFQVSLYKYIFDAMVQGKVTPASLIHHTKLCLDKPLGPSVLRHARQGGVSVKSLGDLMELVFLSLTLSDLPAIDTLKLEYIHQETATILGTEIVAFEEKEVKSKVQHYVAYWMGHRDPQGVDVEEAWKCRTCDYVDICEWRRGSGVLSSSWEPKAKKFK
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
41624
uniprot
proteins
protein_family
EXO5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23095756
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Localizes to repair foci in response to DNA damage. {ECO:0000250}.
uniprot
proteins