TADA2A
entrez
6871
canonical
uniprot
O75478
canonical
ensembl
ENSG00000276234
resolver
ensembl
ENSG00000277104
resolver
ensp
ENSP00000477709
resolver
ensp
ENSP00000478363
resolver
ensp
ENSP00000480446
resolver
ensp
ENSP00000481091
resolver
ensp
ENSP00000523675
resolver
ensp
ENSP00000523676
resolver
ensp
ENSP00000606165
resolver
enst
ENST00000612272
resolver
enst
ENST00000615182
resolver
enst
ENST00000620367
resolver
enst
ENST00000620628
resolver
enst
ENST00000853617
resolver
genesymbol
TADA2A
resolver
genesymbol_syn
TADA2L
resolver
hgnc
HGNC:11531
resolver
uniprot
A0A024R0U3
resolver
uniprot
A0A024R0Y4
resolver
uniprot
A0A087WWR4
resolver
uniprot
A0A0S2Z4G1
resolver
uniprot
A8MVD0
resolver
uniprot
B3KMU9
resolver
uniprot
B3KU13
resolver
uniprot
Q9BVJ0
resolver
uniprot
Q9UCW2
resolver
uniprot
Q9UP49
resolver
uniprot_entry
A0A024R0Y4_HUMAN
resolver
uniprot_entry
A0A087WWR4_HUMAN
resolver
uniprot_entry
A0A0S2Z4G1_HUMAN
resolver
uniprot_entry
B3KU13_HUMAN
resolver
uniprot_entry
TAD2A_HUMAN
resolver
uniprot_sec
A0A024R0U3
resolver
uniprot_sec
A8MVD0
resolver
uniprot_sec
B3KMU9
resolver
uniprot_sec
Q9BVJ0
resolver
uniprot_sec
Q9UCW2
resolver
uniprot_sec
Q9UP49
resolver
amino_acid_sequence
MDRLGPFSNDPSDKPPCRGCSSYLMEPYIKCAECGPPPFFLCLQCFTRGFEYKKHQSDHTYEIMTSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHFINNPLFASTLLNLKQAEEAKTADTAIPFHSTDDPPRPTFDSLLSRDMAGYMPARADFIEEFDNYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKERQRRKKIIRDHGLINLRKFQLMERRYPKEVQDLYETMRRFARIVGPVEHDKFIESHALEFELRREIKRLQEYRTAGITNFCSARTYDHLKKTREEERLKRTMLSEVLQYIQDSSACQQWLRRQADIDSGLSPSIPMASNSGRRSAPPLNLTGLPGTEKLNEKEKELCQMVRLVPGAYLEYKSALLNECNKQGGLRLAQARALIKIDVNKTRKIYDFLIREGYITKG
uniprot
proteins
function
FUNCTION: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376). {ECO:0000250|UniProtKB:Q8CHV6, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:22644376}.
uniprot
proteins
mass_dalton
51506
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19103755
uniprot
proteins
pubmed
22644376
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
8552087
uniprot
proteins
pubmed
9154805
uniprot
proteins
pubmed
9674425
uniprot
proteins
pubmed
9885574
uniprot
proteins
sequence_length
443
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22644376}. Chromosome {ECO:0000250|UniProtKB:Q8CHV6}.
uniprot
proteins