Ccnt1
entrez
12455
canonical
uniprot
Q9QWV9
canonical
ensembl
ENSMUSG00000011960
resolver
ensp
ENSMUSP00000012104
resolver
ensp
ENSMUSP00000126874
resolver
ensp
ENSMUSP00000282458
resolver
ensp
ENSMUSP00000282460
resolver
enst
ENSMUST00000012104
resolver
enst
ENSMUST00000169707
resolver
genesymbol
Ccnt1
resolver
uniprot
Q3V0G4
resolver
uniprot
Q9Z0U7
resolver
uniprot_entry
CCNT1_MOUSE
resolver
uniprot_sec
Q3V0G4
resolver
uniprot_sec
Q9Z0U7
resolver
amino_acid_sequence
MEGERKNNNKRWYFTREQLENSPSRRFGVDSDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFHRYSMAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPSRLKRIRNWRAYQAAMKTKPDDRGADENTSEQTILNMISQTSSDTTIAGLMSMSTASTSAVPSLPSSEESSSSLTSVDMLQGERWLSSQPPFKLEAAQGHRTSESLALIGVDHSLQQDGSSAFGSQKQASKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHDSHSSVILKMPIESSENPERPFLDKADKSALKMRLPVASGDKAVSSKPEEIKMRIKVHSAGDKHNSIEDSVTKSREHKEKQRTHPSNHHHHHNHHSHRHSHLQLPAGPVSKRPSDPKHSSQTSTLAHKTYSLSSTLSSSSSTRKRGPPEETGAAVFDHPAKIAKSTKSSLNFPFPPLPTMTQLPGHSSDTSGLPFSQPSCKTRVPHMKLDKGPPGANGHNATQSIDYQDTVNMLHSLLSAQGVQPTQAPAFEFVHSYGEYMNPRAGAISSRSGTTDKPRPPPLPSEPPPPLPPLPK
uniprot
proteins
function
FUNCTION: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II. {ECO:0000250|UniProtKB:O60563}.
uniprot
proteins
mass_dalton
80598
uniprot
proteins
mutagenesis
MUTAGEN 256; /note="R->W: No effect."; /evidence="ECO:0000269|PubMed:10329126"; MUTAGEN 261; /note="Y->C: Binding to HIV-1 Tat similar to human CCNT1."; /evidence="ECO:0000269|PubMed:10329126, ECO:0000269|PubMed:9832504"; MUTAGEN 262; /note="Q->E: No effect."; /evidence="ECO:0000269|PubMed:10329126"; MUTAGEN 265; /note="M->K: No effect."; /evidence="ECO:0000269|PubMed:10329126"; MUTAGEN 277; /note="N->K: No effect."; /evidence="ECO:0000269|PubMed:10329126
uniprot
proteins
post_translational_modification
PTM: ADP-ribosylation on serine residues by PARP1 in response to DNA damage disrupts the phase separation activity of CCNT1, thereby preventing activation of CDK9. {ECO:0000250|UniProtKB:O60563}.
uniprot
proteins
protein_family
Cyclin C subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
10329126
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27292648
uniprot
proteins
pubmed
9832504
uniprot
proteins
pubmed
9843510
uniprot
proteins
pubmed
9990016
uniprot
proteins
sequence_length
724
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O60563}.
uniprot
proteins