ETS1
entrez
2113
canonical
uniprot
P14921
canonical
ensembl
ENSG00000134954
resolver
ensp
ENSP00000324578
resolver
ensp
ENSP00000376436
resolver
ensp
ENSP00000433500
resolver
ensp
ENSP00000441430
resolver
ensp
ENSP00000570353
resolver
ensp
ENSP00000587630
resolver
genesymbol
ETS1
resolver
genesymbol_syn
EWSR2
resolver
hgnc
HGNC:3488
resolver
uniprot
A8K725
resolver
uniprot
A9UL17
resolver
uniprot
B4DW78
resolver
uniprot
F5GYX9
resolver
uniprot
Q14278
resolver
uniprot
Q16080
resolver
uniprot
Q6N087
resolver
uniprot
Q96AC5
resolver
uniprot_entry
A8K725_HUMAN
resolver
uniprot_entry
B4DW78_HUMAN
resolver
uniprot_entry
ETS1_HUMAN
resolver
uniprot_sec
A9UL17
resolver
uniprot_sec
F5GYX9
resolver
uniprot_sec
Q14278
resolver
uniprot_sec
Q16080
resolver
uniprot_sec
Q6N087
resolver
uniprot_sec
Q96AC5
resolver
activity_regulation
ACTIVITY REGULATION: Autoinhibited by a module composed of four alpha helices (HI-1, HI-2, H4, and H5) that flank the DNA-binding ETS domain, reducing the affinity for DNA. Phosphorylation by CaMK2/CaMKII in response to calcium signaling decreases affinity for DNA. {ECO:0000250|UniProtKB:P27577}.
uniprot
proteins
amino_acid_sequence
MKAAVDLKPTLTIIKTEKVDLELFPSPDMECADVPLLTPSSKEMMSQALKATFSGFTKEQQRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFCMNGAALCALGKDCFLELAPDFVGDILWEHLEILQKEDVKPYQVNGVNPAYPESRYTSDYFISYGIEHAQCVPPSEFSEPSFITESYQTLHPISSEELLSLKYENDYPSVILRDPLQTDTLQNDYFAIKQEVVTPDNMCMGRTSRGKLGGQDSFESIESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDSEDYPAALPNHKPKGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVKPDADE
uniprot
proteins
function
FUNCTION: Transcription factor (PubMed:10698492, PubMed:11909962). Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts (PubMed:20378371). May control the differentiation, survival and proliferation of lymphoid cells (PubMed:20378371). May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (PubMed:15247905, PubMed:15592518). {ECO:0000269|PubMed:10698492, ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000303|PubMed:20378371}.; FUNCTION: [Isoform Ets-1 p27]: Acts as a dominant-negative for isoform c-ETS-1A. {ECO:0000269|PubMed:19377509}.
uniprot
proteins
mass_dalton
50408
uniprot
proteins
post_translational_modification
PTM: Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity. {ECO:0000250|UniProtKB:P27577}.; PTM: Ubiquitinated; which induces proteasomal degradation. {ECO:0000250|UniProtKB:P27577}.; PTM: Phosphorylation at Ser-251, Ser-282 and Ser-285 by CaMK2/CaMKII in response to calcium signaling decreases affinity for DNA: an increasing number of phosphoserines causes DNA-binding to become progressively weaker. {ECO:0000250|UniProtKB:P27577}.
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
10698492
uniprot
proteins
pubmed
11909962
uniprot
proteins
pubmed
15247905
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15592518
uniprot
proteins
pubmed
1614856
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18566588
uniprot
proteins
pubmed
19377509
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20378371
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
2847145
uniprot
proteins
pubmed
2997781
uniprot
proteins
pubmed
3060801
uniprot
proteins
pubmed
8231246
uniprot
proteins
pubmed
8521493
uniprot
proteins
pubmed
9333025
uniprot
proteins
sequence_length
441
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:19377509}. Cytoplasm {ECO:0000269|PubMed:19377509}. Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. {ECO:0000269|PubMed:19377509}.
uniprot
proteins