Ipo4
entrez
75751
canonical
uniprot
Q8VI75
canonical
ensembl
ENSMUSG00000002319
resolver
ensp
ENSMUSP00000036555
resolver
ensp
ENSMUSP00000234248
resolver
enst
ENSMUST00000047131
resolver
genesymbol
Ipo4
resolver
genesymbol_syn
Imp4a
resolver
genesymbol_syn
Ranbp4
resolver
uniprot
Q3TBW0
resolver
uniprot
Q99J52
resolver
uniprot_entry
IPO4_MOUSE
resolver
uniprot_sec
Q3TBW0
resolver
uniprot_sec
Q99J52
resolver
amino_acid_sequence
MEPAGLEQILKELLLPDTERIRRATEQLQTILRDPAALPALFDLLATATDSQIRQFAAVLTRRRLNNRWRRLAPEQRESLKSLVLTALQKETVHSVSVSLAQLSATIFRKEGLQGWPQFMNLLQHSTHSSHSPEKEVGLLLLSVVVSSQPEAFHAHQHELLQLLNETLSDVSFPGVLFYSLRTLTAIARYVRPDDVSLARMLVPKVVTALRTLIPLDEVKACEALEALDEMLETELPIINPHLSEVLTFCLEVAKNVALGEPLRVRVLCCLTFLVKVKSKALLKNRLVPPLLHALFPLMAAEPPMGQLDPEDQDSDDDDLEIGLMGETPKHFAVQVVDMLALHLPPEKLCPHVMPMLEEALRSEDPYQRKAGFLVLAVLSDGAGDHIRQRLLYPLLQIVCKGLDDPSQIVRNAALFALGQFSENLQPHISSYSEEVMPLLLSYLKSVPMGNTHHLAKACYALENFVENLGPKVQPYLPELMECMLQPLKNPSKARTKELAVSAIGAIATAAQDSLLPYFPTIMDLLREFLLTGHEDFHLVQIQSLETLGVLARALGESMKPLAEECCQLGLGLCIHIDDPDVRRCTYSLFAALSGLMGEGLGPYLPQITTLMLLSLRSTEGIVPQYDGISSFLLFDDDSEAEEEEELMDEDMEEEGDDSEISGYSVENAFFDEKEDTCTALGEISMNTCVAFLPFMDATFDEVYKLLECPHMNVRKSAYEALGQFCCALHKASQRSSSDPSSSPVLQTSLARVMPAYMQAVKVERERPVVMAVLESLTGVLRTCGSLALQPPGRLSELCNVLKAVLQKKTACQDAEEDDDEDDDQAEYDAMLLEHAGEAIPVLAATAGGHAFAPFFATFLPLLLCKTKQSCTVAEKSFAVGTLAESIQGLGTASAQFVSRLFPVLLNNAREADPEVRSNAIFGLGVLAEHGGCPAQDHFPKLLGLLLPLLARERHDRVRDNICGALARVLMASPVGKTEPQVLATLLRALPLKEDMEEWLTIGHLFSFLHQNNPEQVVDVASELLRICSLILPDNRIPPDTKAALLLLLTFLAKQHTDSFHTALGSLPNDKAQELQAMMGLT
uniprot
proteins
function
FUNCTION: Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of the histone H3-H4 dimer when in complex with ASF1 (ASF1A or ASF1B). Also mediates the nuclear import of monomeric histones H3.1 and H4. Mediates the ligand-independent nuclear import of vitamin D receptor (VDR). {ECO:0000250|UniProtKB:Q8TEX9}.
uniprot
proteins
mass_dalton
119275
uniprot
proteins
protein_family
Importin beta family
uniprot
proteins
pubmed
11823430
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1082
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TEX9}. Nucleus {ECO:0000250|UniProtKB:Q8TEX9}.
uniprot
proteins