APOBEC3C
entrez
27350
canonical
uniprot
Q9NRW3
canonical
ensembl
ENSG00000244509
resolver
ensp
ENSP00000355340
resolver
enst
ENST00000361441
resolver
genesymbol
APOBEC3C
resolver
genesymbol_syn
APOBEC1L
resolver
genesymbol_syn
PBI
resolver
hgnc
HGNC:17353
resolver
uniprot
B2R884
resolver
uniprot
Q5JZ92
resolver
uniprot
Q7Z2N7
resolver
uniprot
Q96F12
resolver
uniprot_entry
ABC3C_HUMAN
resolver
uniprot_sec
B2R884
resolver
uniprot_sec
Q5JZ92
resolver
uniprot_sec
Q7Z2N7
resolver
uniprot_sec
Q96F12
resolver
activity_regulation
ACTIVITY REGULATION: (Microbial infection) Antiviral activity is neutralized by the HIV-1 virion infectivity factor (Vif), that prevents its incorporation into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. {ECO:0000250|UniProtKB:Q96AK3}.
uniprot
proteins
amino_acid_sequence
MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKRRSVVSWKTGVFRNQVDSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEFLARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLKTNFRLLKRRLRESLQ
uniprot
proteins
ec_number
3.5.4.38
uniprot
proteins
function
FUNCTION: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:15466872, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21632763}.
uniprot
proteins
mass_dalton
22826
uniprot
proteins
mutagenesis
MUTAGEN 72; /note="L->D: Resistant to HIV-1 Vif and abolishes Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 75; /note="F->W: Resistant to HIV-1 Vif and reduces Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 76; /note="C->K: Resistant to HIV-1 Vif and reduces Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 79; /note="I->A: Resistant to HIV-1 Vif and reduces Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 80; /note="L->A: Resistant to HIV-1 Vif and reduces Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 81; /note="S->P: Resistant to HIV-1 Vif and reduces Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 86; /note="Y->A: Resistant to HIV-1 Vif and abolishes Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 106; /note="E->K: Resistant to HIV-1 Vif and reduces Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 107; /note="F->D: Resistant to HIV-1 Vif and abolishes Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 109; /note="A->K: Resistant to HIV-1 Vif."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 111; /note="H->D: Resistant to HIV-1 Vif and reduces Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 129; /note="P->A: No effect on Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 141; /note="E->K: Remains sensitive to HIV-1 Vif but abolishes Vif binding."; /evidence="ECO:0000269|PubMed:23001005
uniprot
proteins
protein_family
Cytidine and deoxycytidylate deaminase family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11863358
uniprot
proteins
pubmed
12859895
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15466872
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16527742
uniprot
proteins
pubmed
18304004
uniprot
proteins
pubmed
18448976
uniprot
proteins
pubmed
19074429
uniprot
proteins
pubmed
20062055
uniprot
proteins
pubmed
20308164
uniprot
proteins
pubmed
21496894
uniprot
proteins
pubmed
21632763
uniprot
proteins
pubmed
21835787
uniprot
proteins
pubmed
22001110
uniprot
proteins
pubmed
22912627
uniprot
proteins
pubmed
22915799
uniprot
proteins
pubmed
22977230
uniprot
proteins
pubmed
23001005
uniprot
proteins
sequence_length
190
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22977230}. Cytoplasm {ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22977230}.
uniprot
proteins