Htr1d
entrez
25323
canonical
uniprot
P28565
canonical
ensembl
ENSRNOG00000012038
resolver
ensembl
ENSRNOG00055024659
resolver
ensembl
ENSRNOG00060032149
resolver
ensembl
ENSRNOG00065022383
resolver
ensp
ENSRNOP00000016047
resolver
ensp
ENSRNOP00000104073
resolver
ensp
ENSRNOP00055034668
resolver
ensp
ENSRNOP00060046050
resolver
ensp
ENSRNOP00065030897
resolver
enst
ENSRNOT00000016046
resolver
enst
ENSRNOT00000171476
resolver
enst
ENSRNOT00055042452
resolver
enst
ENSRNOT00060055687
resolver
enst
ENSRNOT00065038164
resolver
genesymbol
Htr1d
resolver
uniprot_entry
5HT1D_RAT
resolver
amino_acid_sequence
MSLPNQSLEGLPQEASNRSLNATGAWDPEVLQALRISLVVVLSIITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWAISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVVHFRKAS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:19912901, PubMed:8978753). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (By similarity). Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity (By similarity). May also play a role in regulating the release of other neurotransmitters (By similarity). May play a role in vasoconstriction (By similarity). {ECO:0000250|UniProtKB:P28221, ECO:0000269|PubMed:19912901, ECO:0000269|PubMed:8978753}.
uniprot
proteins
mass_dalton
41540
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
19912901
uniprot
proteins
pubmed
8978753
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19912901, ECO:0000269|PubMed:8978753}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P28221}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..61; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P28221"; TRANSMEM 73..94; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P28221"; TRANSMEM 107..131; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P28221"; TRANSMEM 152..173; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P28221"; TRANSMEM 192..215; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P28221"; TRANSMEM 298..323; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P28221"; TRANSMEM 333..356; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P28221
uniprot
proteins