SET
entrez
6418
canonical
uniprot
Q01105
canonical
ensembl
ENSG00000119335
resolver
ensp
ENSP00000318012
resolver
ensp
ENSP00000361771
resolver
ensp
ENSP00000361777
resolver
ensp
ENSP00000387321
resolver
ensp
ENSP00000509032
resolver
enst
ENST00000372686
resolver
genesymbol
SET
resolver
hgnc
HGNC:10760
resolver
uniprot
A0A8J8YYJ1
resolver
uniprot
A5A5H4
resolver
uniprot
A6NGV1
resolver
uniprot
B4DUE2
resolver
uniprot
Q15541
resolver
uniprot
Q5VXV1
resolver
uniprot
Q5VXV2
resolver
uniprot
Q5VXV3
resolver
uniprot
Q6FHZ5
resolver
uniprot_entry
A0A8J8YYJ1_HUMAN
resolver
uniprot_entry
Q5VXV3_HUMAN
resolver
uniprot_entry
SET_HUMAN
resolver
uniprot_sec
A5A5H4
resolver
uniprot_sec
A6NGV1
resolver
uniprot_sec
B4DUE2
resolver
uniprot_sec
Q15541
resolver
uniprot_sec
Q5VXV1
resolver
uniprot_sec
Q5VXV2
resolver
uniprot_sec
Q6FHZ5
resolver
amino_acid_sequence
MAPKRQSPLPPQKKKPRPPPALGPEETSASAGLPKKGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEGEEDDDDDEEEEGLEDIDEEGDEDEGEEDEDDDEGEEGEEDEGEDD
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving SET is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with NUP214/CAN.; DISEASE: Intellectual developmental disorder, autosomal dominant 58 (MRD58) [MIM:618106]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD58 patients show delayed development, intellectual disability, language delay and speech impairment. Some patients have motor delay or incoordination, and minor dysmorphic features. {ECO:0000269|PubMed:25356899, ECO:0000269|PubMed:29688601}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}.
uniprot
proteins
mass_dalton
33489
uniprot
proteins
post_translational_modification
PTM: Isoform 2 is phosphorylated on Ser-15 and Ser-24.; PTM: Isoform 2 is acetylated on Lys-11.; PTM: Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity). {ECO:0000250}.; PTM: N-terminus of isoform 1 is methylated by METTL11A/NTM1. Mainly trimethylated (By similarity). {ECO:0000250}.; PTM: [Isoform 2]: Cleaved after Lys-176 by GZMA. The cleavage inhibits its nucleosome assembly activity and disrupts the inhibition on NME1. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237}.
uniprot
proteins
protein_family
Nucleosome assembly protein (NAP) family
uniprot
proteins
pubmed
11163245
uniprot
proteins
pubmed
11231286
uniprot
proteins
pubmed
11555662
uniprot
proteins
pubmed
11909973
uniprot
proteins
pubmed
12524539
uniprot
proteins
pubmed
12628186
uniprot
proteins
pubmed
12917472
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15642345
uniprot
proteins
pubmed
1630450
uniprot
proteins
pubmed
16541025
uniprot
proteins
pubmed
16818237
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17360516
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19343227
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25356899
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29688601
uniprot
proteins
pubmed
7753797
uniprot
proteins
pubmed
8192856
uniprot
proteins
pubmed
8294483
uniprot
proteins
pubmed
8626647
uniprot
proteins
pubmed
9773788
uniprot
proteins
sequence_length
290
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus, nucleoplasm. Note=In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. The SET complex is associated with the endoplasmic reticulum. Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium.
uniprot
proteins