Ptpn1
entrez
19246
canonical
uniprot
P35821
canonical
ensembl
ENSMUSG00000027540
resolver
ensp
ENSMUSP00000029053
resolver
ensp
ENSMUSP00000198756
resolver
enst
ENSMUST00000029053
resolver
genesymbol
Ptpn1
resolver
uniprot
Q3TZW9
resolver
uniprot
Q60840
resolver
uniprot
Q62131
resolver
uniprot
Q64498
resolver
uniprot
Q99JS1
resolver
uniprot_entry
PTN1_MOUSE
resolver
uniprot_entry
Q3TZW9_MOUSE
resolver
uniprot_sec
Q60840
resolver
uniprot_sec
Q62131
resolver
uniprot_sec
Q64498
resolver
uniprot_sec
Q99JS1
resolver
amino_acid_sequence
MEMEKEFEEIDKAGNWAAIYQDIRHEASDFPCKVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRIMEKGSLKCAQYWPQQEEKEMVFDDTGLKLTLISEDVKSYYTVRQLELENLTTKETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSLEHGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRRFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSREDLDLPPEHVPPPPRPPKRTLEPHNGKCKELFSSHQWVSEETCGDEDSLAREEGRAQSSAMHSVSSMSPDTEVRRRMVGGGLQSAQASVPTEEELSSTEEEHKAHWPSHWKPFLVNVCMATLLATGAYLCYRVCFH
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
49593
uniprot
proteins
post_translational_modification
PTM: Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50 (By similarity). {ECO:0000250}.; PTM: S-nitrosylation of Cys-215 inactivates the enzyme activity. {ECO:0000250}.; PTM: Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity. {ECO:0000250}.
uniprot
proteins
protein_family
Non-receptor class 1 subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
1378268
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
1932742
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7832766
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Interacts with EPHA3 at the cell membrane. {ECO:0000250}.
uniprot
proteins