Tspan14
entrez
52588
canonical
uniprot
Q8QZY6
canonical
ensembl
ENSMUSG00000037824
resolver
ensp
ENSMUSP00000035263
resolver
ensp
ENSMUSP00000153208
resolver
ensp
ENSMUSP00000240117
resolver
ensp
ENSMUSP00000240127
resolver
enst
ENSMUST00000047652
resolver
enst
ENSMUST00000224209
resolver
genesymbol
Tspan14
resolver
genesymbol_syn
D14Ertd226e
resolver
genesymbol_syn
Tm4sf14
resolver
uniprot_entry
TSN14_MOUSE
resolver
amino_acid_sequence
MHYYRYSNAEVSCWYKYLLFSYNIVFWLAGVVFLGVGLWAWSEKGVLSDLTKVTRLHGIDPVVLVLMVGVVMFTLGFAGCVGALRENICLLKFFCGAIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDLQNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDVRIQLKSKWDEFIFTKGCIQALEGWLPRNIYIVAGVFIAISLLQIFGIFLARTLISDIEAVKAGHHF
uniprot
proteins
function
FUNCTION: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:23035126, PubMed:26668317). Negatively regulates ADAM10-mediated cleavage of GP6 (PubMed:26668317). Promotes ADAM10-mediated cleavage of CDH5 (PubMed:23035126). {ECO:0000269|PubMed:23035126, ECO:0000269|PubMed:26668317}.
uniprot
proteins
mass_dalton
30674
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23035126
uniprot
proteins
pubmed
26668317
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8NG11}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins