Rap2a
entrez
76108
canonical
uniprot
Q80ZJ1
canonical
ensembl
ENSMUSG00000051615
resolver
ensp
ENSMUSP00000056433
resolver
genesymbol
Rap2a
resolver
uniprot
Q3USK1
resolver
uniprot
Q7TSK4
resolver
uniprot
Q810A2
resolver
uniprot
Q9D3D5
resolver
uniprot_entry
RAP2A_MOUSE
resolver
uniprot_sec
Q3USK1
resolver
uniprot_sec
Q7TSK4
resolver
uniprot_sec
Q810A2
resolver
uniprot_sec
Q9D3D5
resolver
activity_regulation
ACTIVITY REGULATION: Activated by the guanine nucleotide-exchange factors RAPGEF3 and RAPGEF4 in a cAMP-dependent manner. Nucleotide exchange is also specifically stimulated by RAPGEF5, RASGEF1A and RASGEF1B. {ECO:0000250|UniProtKB:P10114}.
uniprot
proteins
amino_acid_sequence
MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDLESEREVSSNEGRALAEEWGCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSACNIQ
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading. {ECO:0000269|PubMed:12133960, ECO:0000269|PubMed:18701680, ECO:0000269|PubMed:19061864}.
uniprot
proteins
mass_dalton
20642
uniprot
proteins
mutagenesis
MUTAGEN 17; /note="S->N: Loss of affinity for GTP and loss of interaction with RUNDC3A."; /evidence="ECO:0000269|PubMed:9523700"; MUTAGEN 35; /note="T->A: Loss of interaction with RUNDC3A."; /evidence="ECO:0000269|PubMed:9523700"; MUTAGEN 176; /note="C->G: Loss of association with the recycling endosome membranes and loss of TNIK activation; when associated with C-177."; /evidence="ECO:0000269|PubMed:19061864"; MUTAGEN 177; /note="C->G: Loss of association with the recycling endosome membranes and loss of TNIK activation; when associated with C-176."; /evidence="ECO:0000269|PubMed:19061864"; MUTAGEN 180; /note="C->A: Loss of association with membranes."; /evidence="ECO:0000269|PubMed:19061864
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; undergoes 'Lys-63' monoubiquitination and diubiquitination by NEDD4. Multiple lysine residues are probably modified. Ubiquitination requires TNIK, prevents interaction with effectors and inactivates RAP2A. Ubiquitination by the ECS(RAB40B) complex leads to RAP2A localization to lamellipodia plasma membrane, activation, and regulation of sorting at early endosomes for recycling to the lamellipodia plasma membrane (By similarity). {ECO:0000250|UniProtKB:P10114, ECO:0000269|PubMed:20159449}.; PTM: Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK. {ECO:0000269|PubMed:19061864}.
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10926822
uniprot
proteins
pubmed
12133960
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18701680
uniprot
proteins
pubmed
19061864
uniprot
proteins
pubmed
20159449
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9523700
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Midbody {ECO:0000250|UniProtKB:P10114}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:P10114}. Golgi apparatus {ECO:0000250|UniProtKB:P10114}. Recycling endosome membrane {ECO:0000269|PubMed:19061864}; Lipid-anchor {ECO:0000269|PubMed:19061864}; Cytoplasmic side {ECO:0000269|PubMed:19061864}. Lysosome {ECO:0000250|UniProtKB:P10114}. Note=Localized to the Golgi. May also localize to the gelatinase-containing granules of neutrophils. Colocalized with RASGEF1B to midbody at telophase. Localized predominantly to the plasma membrane, where it is enriched at lamellipodia ruffles. Cycles between the lamellipodia plasma membrane and endosomes when ubiquitinated by the ECS(RAB40B) complex. Without the ubiquitin signal, sorted to lysosomes for degradation. {ECO:0000250|UniProtKB:P10114}.
uniprot
proteins