PRR14
entrez
78994
canonical
uniprot
Q9BWN1
canonical
ensembl
ENSG00000156858
resolver
ensp
ENSP00000300835
resolver
ensp
ENSP00000441641
resolver
enst
ENST00000300835
resolver
enst
ENST00000542965
resolver
genesymbol
PRR14
resolver
hgnc
HGNC:28458
resolver
uniprot
Q8WTX2
resolver
uniprot_entry
PRR14_HUMAN
resolver
uniprot_sec
Q8WTX2
resolver
amino_acid_sequence
MDLPGDSSPPGQPRLCRQPLTRALWGARSPKRPRLQLPGAPSPLEKASRRVLAVVLEDVMAVHMVPVVPSKQTSIPQHHSYHQDPVHRQPPASPPRQAGWSSQARPPDPLCLCREPLSRIHRTSSTLRRRSRTTPGPEEGPSQKVDRAPQPTLVVMLEDIASPRPPAEGFIDETPNFIIPAQRAEPMRIVRQPTPPPGDLEPPFQPSALPADPLESPPTAPDPALELPSTPPPSSLLRPRLSPWGLAPLFRSVRSKLESFADIFLTPNKTPQPPPPSPPMKLELKIAISEAEQSGAAEGTASVSPRPPIRQWRTQDHNTPALLPKPSLGRSYSCPDLGPPGPGTCTWPPAPPQPSRPRPRRHTVGGGEMARAPPPPRPCLRKEVFPLGGVGASPSLTTSCSSTASTSFSEPAEPRLGSTKGKEPRASKDQVLSEPETKTMGKVSRFRIRRTPARPQLNLTPMGLPRPIRLNKKEFSLEEIYTNKNYQSPTTRRTFETIFEEPRERNGTLIFTSSRKLRRAVEFRDSSLPRSRRPSRGVRAAGGRTVPPNVAPSPDVGPLLQQRLEELDALLLEEETVDREQPHWT
uniprot
proteins
function
FUNCTION: Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574). {ECO:0000269|PubMed:24209742, ECO:0000269|PubMed:25906157, ECO:0000269|PubMed:27041574}.
uniprot
proteins
mass_dalton
64328
uniprot
proteins
mutagenesis
MUTAGEN 54..55; /note="VV->AA: Loss of heterochromatin association. Loss of interaction with CBX5."; /evidence="ECO:0000269|PubMed:24209742, ECO:0000269|PubMed:25906157"; MUTAGEN 54..55; /note="VV->EE: Loss of heterochromatin association during interphase and loss of chromatin association during anaphase."; /evidence="ECO:0000269|PubMed:24209742"; MUTAGEN 101; /note="S->C: Increased binding to GRB2 and enhanced cell proliferation."; /evidence="ECO:0000269|PubMed:27041574"; MUTAGEN 566; /note="E->K: Increased binding to GRB2 and enhanced cell proliferation."; /evidence="ECO:0000269|PubMed:27041574
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24209742
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25906157
uniprot
proteins
pubmed
27041574
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:24209742}. Nucleus {ECO:0000269|PubMed:25906157}. Nucleus lamina {ECO:0000269|PubMed:24209742}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24209742}. Note=During interphase, associated with peripheral heterochromatin at the nuclear lamina. Released from the nuclear lamina in mitotic prophase and remains highly dispersed in metaphase. Associates with chromatin at the onset of anaphase and relocalizes to the nuclear lamina in telophase. {ECO:0000269|PubMed:24209742}.
uniprot
proteins