Arhgef2
entrez
310635
canonical
uniprot
Q5FVC2
canonical
ensembl
ENSRNOG00000020027
resolver
ensembl
ENSRNOG00055024384
resolver
ensembl
ENSRNOG00060032612
resolver
ensembl
ENSRNOG00065028306
resolver
ensp
ENSRNOP00000027182
resolver
ensp
ENSRNOP00000071595
resolver
ensp
ENSRNOP00000076068
resolver
ensp
ENSRNOP00000091462
resolver
ensp
ENSRNOP00000094178
resolver
ensp
ENSRNOP00000095755
resolver
ensp
ENSRNOP00055034362
resolver
ensp
ENSRNOP00060046706
resolver
ensp
ENSRNOP00065040203
resolver
enst
ENSRNOT00000027182
resolver
enst
ENSRNOT00000081531
resolver
enst
ENSRNOT00000099415
resolver
enst
ENSRNOT00000105386
resolver
enst
ENSRNOT00000119126
resolver
enst
ENSRNOT00055042129
resolver
enst
ENSRNOT00060056539
resolver
enst
ENSRNOT00065049018
resolver
genesymbol
Arhgef2
resolver
uniprot
A0A0G2K0V4
resolver
uniprot
A0A8I6AFM5
resolver
uniprot
A0A8I6AK99
resolver
uniprot
A0A8I6GLA8
resolver
uniprot_entry
A0A0G2K0V4_RAT
resolver
uniprot_entry
A0A8I6AFM5_RAT
resolver
uniprot_entry
A0A8I6AK99_RAT
resolver
uniprot_entry
A0A8I6GLA8_RAT
resolver
uniprot_entry
ARHG2_RAT
resolver
amino_acid_sequence
MSRIESLTRARIDRSKEQATKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLRNNTALQSVSLRSKTTTRERPTSAIYPSDSFRQSLLGSRRGLSSLSLAKSVSTTNIAGHFNDESPLGLRQILSQSTDSLNMRNRTLSVESLIDEGVEVFYNELMSDFEMDEKDFEADSWSLAVDSSFLQQHKKEVMKKQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELQMEPEVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGSNAEQMRKTYSEFCSRHTKALKLYKELYARDKRFQQFIRKMTRSAVLKRHGVQECILLVTQRITKYPVLINRILQNSHGIEEEYQDLAAALGLVKELLSNVDQDVHELEKEARLQEIYNRMDPRAQTPVPGKGPFGRDELLRRKLIHDGCLLWKTATGRFKDVLLLLMTDVLVFLQEKDQKYIFTSLDKPSVVSLQNLIVRDIANQAKGMFLISSGPPEMYEVHAASRDDRTTWIRVIQQSVRLCPSREDFPLIETEDKAYLRRIKTKLQQKNQALVELLQMNVELFAEMVHFQALKAGFIGMPPPTLPRGLFRLESFESLRGERLLKDALREVEGLKDLLLGPCVDLPLTAREPALPVEADSGSCPGVTANGEARTFNGSIELCRADSDSSQKDRNGNQLRSPQEEALQPLVNLYGLLQGLQAVVVQQERLMEALFPEGPERWEKLSRANSRDGEAGRAAVASVTPEKQATELALLQRQHSLLQEELRRCQRLGEERATEAGSLEARLRESEQARALLEREAEEIRRQLAALGQNEPLPAEAPWARRPLDPRRRSLPAGDALYLSFNPPQPSRGHDRLDLPVTVRSLHRPFDDREAQELGSPEDRLQDSSDPDTCSEEEVSSRLSPPHSPRDFTRMQDIPEETESRDGEPTASES
uniprot
proteins
function
FUNCTION: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability. Involved in neuronal progenitor cell division and differentiation. Involved in the migration of precerebellar neurons. {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3}.
uniprot
proteins
mass_dalton
111909
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-885 by PAK1 induces binding to protein YWHAZ, promoting its relocation to microtubules and the inhibition of its activity. Phosphorylated by AURKA and CDK1 during mitosis, which negatively regulates its activity. Phosphorylation by MAPK1 or MAPK3 increases nucleotide exchange activity. Phosphorylation by PAK4 releases GEF-H1 from the microtubules. Phosphorylated on serine, threonine and tyrosine residues in a RIPK2-dependent manner (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18394899
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
985
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q865S3, ECO:0000250|UniProtKB:Q92974}. Cytoplasm {ECO:0000250|UniProtKB:Q865S3, ECO:0000250|UniProtKB:Q92974}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q865S3, ECO:0000250|UniProtKB:Q92974}. Golgi apparatus {ECO:0000250|UniProtKB:Q92974}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q865S3, ECO:0000250|UniProtKB:Q92974}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q92974}. Note=Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization. Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton. {ECO:0000250|UniProtKB:Q92974}.
uniprot
proteins