RANGAP1
entrez
5905
canonical
uniprot
P46060
canonical
ensembl
ENSG00000100401
resolver
ensp
ENSP00000348577
resolver
ensp
ENSP00000385866
resolver
ensp
ENSP00000401470
resolver
ensp
ENSP00000516069
resolver
ensp
ENSP00000568533
resolver
ensp
ENSP00000568534
resolver
ensp
ENSP00000568535
resolver
ensp
ENSP00000568536
resolver
ensp
ENSP00000568537
resolver
ensp
ENSP00000568538
resolver
ensp
ENSP00000568539
resolver
ensp
ENSP00000568541
resolver
ensp
ENSP00000568542
resolver
ensp
ENSP00000568544
resolver
ensp
ENSP00000568548
resolver
ensp
ENSP00000568550
resolver
ensp
ENSP00000568551
resolver
ensp
ENSP00000568552
resolver
ensp
ENSP00000568553
resolver
ensp
ENSP00000568554
resolver
ensp
ENSP00000568555
resolver
ensp
ENSP00000568557
resolver
ensp
ENSP00000568560
resolver
ensp
ENSP00000568561
resolver
ensp
ENSP00000602930
resolver
ensp
ENSP00000602931
resolver
ensp
ENSP00000602933
resolver
ensp
ENSP00000602935
resolver
ensp
ENSP00000602936
resolver
ensp
ENSP00000602940
resolver
ensp
ENSP00000602941
resolver
ensp
ENSP00000602942
resolver
ensp
ENSP00000602945
resolver
ensp
ENSP00000602949
resolver
ensp
ENSP00000602950
resolver
ensp
ENSP00000602951
resolver
ensp
ENSP00000602952
resolver
ensp
ENSP00000602953
resolver
ensp
ENSP00000602954
resolver
ensp
ENSP00000632634
resolver
ensp
ENSP00000632635
resolver
ensp
ENSP00000632637
resolver
ensp
ENSP00000632638
resolver
ensp
ENSP00000632639
resolver
ensp
ENSP00000632641
resolver
ensp
ENSP00000632642
resolver
ensp
ENSP00000632643
resolver
ensp
ENSP00000632644
resolver
ensp
ENSP00000632645
resolver
ensp
ENSP00000632646
resolver
ensp
ENSP00000632647
resolver
ensp
ENSP00000632648
resolver
ensp
ENSP00000632651
resolver
ensp
ENSP00000632652
resolver
ensp
ENSP00000632653
resolver
ensp
ENSP00000632654
resolver
ensp
ENSP00000632655
resolver
ensp
ENSP00000632656
resolver
ensp
ENSP00000632657
resolver
ensp
ENSP00000632658
resolver
ensp
ENSP00000632661
resolver
ensp
ENSP00000719688
resolver
ensp
ENSP00000788373
resolver
enst
ENST00000356244
resolver
enst
ENST00000405486
resolver
enst
ENST00000455915
resolver
enst
ENST00000705116
resolver
enst
ENST00000898474
resolver
enst
ENST00000898475
resolver
enst
ENST00000898476
resolver
enst
ENST00000898477
resolver
enst
ENST00000898478
resolver
enst
ENST00000898479
resolver
enst
ENST00000898480
resolver
enst
ENST00000898482
resolver
enst
ENST00000898483
resolver
enst
ENST00000898485
resolver
enst
ENST00000898489
resolver
enst
ENST00000898491
resolver
enst
ENST00000898492
resolver
enst
ENST00000898493
resolver
enst
ENST00000898494
resolver
enst
ENST00000898495
resolver
enst
ENST00000898496
resolver
enst
ENST00000898498
resolver
enst
ENST00000898501
resolver
enst
ENST00000898502
resolver
enst
ENST00000932871
resolver
enst
ENST00000932872
resolver
enst
ENST00000932874
resolver
enst
ENST00000932876
resolver
enst
ENST00000932877
resolver
enst
ENST00000932881
resolver
enst
ENST00000932882
resolver
enst
ENST00000932883
resolver
enst
ENST00000932886
resolver
enst
ENST00000932890
resolver
enst
ENST00000932891
resolver
enst
ENST00000932892
resolver
enst
ENST00000932893
resolver
enst
ENST00000932894
resolver
enst
ENST00000932895
resolver
enst
ENST00000962575
resolver
enst
ENST00000962576
resolver
enst
ENST00000962578
resolver
enst
ENST00000962579
resolver
enst
ENST00000962580
resolver
enst
ENST00000962582
resolver
enst
ENST00000962583
resolver
enst
ENST00000962584
resolver
enst
ENST00000962585
resolver
enst
ENST00000962586
resolver
enst
ENST00000962587
resolver
enst
ENST00000962588
resolver
enst
ENST00000962589
resolver
enst
ENST00000962592
resolver
enst
ENST00000962593
resolver
enst
ENST00000962594
resolver
enst
ENST00000962595
resolver
enst
ENST00000962596
resolver
enst
ENST00000962597
resolver
enst
ENST00000962598
resolver
enst
ENST00000962599
resolver
enst
ENST00000962602
resolver
genesymbol
RANGAP1
resolver
genesymbol_syn
KIAA1835
resolver
genesymbol_syn
SD
resolver
hgnc
HGNC:9854
resolver
uniprot
Q96JJ2
resolver
uniprot
Q9BSK3
resolver
uniprot_entry
Q9BSK3_HUMAN
resolver
uniprot_entry
RAGP1_HUMAN
resolver
uniprot_sec
Q96JJ2
resolver
amino_acid_sequence
MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDAKDVIKEIEDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGEPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEKVVSAFLKVSSVFKDEATVRMAVQDAVDALMQKAFNSSSFNSNTFLTRLLVHMGLLKSEDKVKAIANLYGPLMALNHMVQQDYFPKALAPLLLAFVTKPNSALESCSFARHSLLQTLYKV
uniprot
proteins
function
FUNCTION: GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}.
uniprot
proteins
mass_dalton
63542
uniprot
proteins
mutagenesis
MUTAGEN 91; /note="R->A: Abolishes RANGTPase activation."; /evidence="ECO:0000269|PubMed:16428860"; MUTAGEN 356; /note="S->A: No effect on phosphorylation."; /evidence="ECO:0000269|PubMed:16428860"; MUTAGEN 358; /note="S->A: Strongly decreased phosphorylation. No effect on sumoylation."; /evidence="ECO:0000269|PubMed:16428860"; MUTAGEN 524; /note="K->R: Loss of cross-link to SUMO1. Abolishes association with nuclear pores during interphase, and with mitotic spindles during mitosis."; /evidence="ECO:0000269|PubMed:11854305
uniprot
proteins
post_translational_modification
PTM: Phosphorylation occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the M-phase kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis. The phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBE2I, on nuclear pore complex (NPC) disassembly and during mitosis. {ECO:0000269|PubMed:15037602}.; PTM: Sumoylated (PubMed:11854305, PubMed:15037602, PubMed:26304119, PubMed:27160050). Sumoylation is necessary for targeting to the nuclear envelope (NE), and for association with mitotic spindles and kinetochores during mitosis (PubMed:11854305). Also required for interaction with RANBP2 and is mediated by UBE2I (PubMed:27160050). Desumoylated by HINT1 (By similarity). {ECO:0000250|UniProtKB:P46061, ECO:0000269|PubMed:11854305, ECO:0000269|PubMed:15037602, ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:20388717, ECO:0000269|PubMed:26304119, ECO:0000305|PubMed:27160050}.
uniprot
proteins
protein_family
RNA1 family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
11854305
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14729961
uniprot
proteins
pubmed
15037602
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15931224
uniprot
proteins
pubmed
16428860
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17099698
uniprot
proteins
pubmed
18093978
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20388717
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22194619
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
26304119
uniprot
proteins
pubmed
27160050
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
7878053
uniprot
proteins
pubmed
7891706
uniprot
proteins
pubmed
8146159
uniprot
proteins
pubmed
8896452
uniprot
proteins
pubmed
8973340
uniprot
proteins
sequence_length
587
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15037602, ECO:0000305|PubMed:8146159}. Nucleus, nucleoplasm {ECO:0000269|PubMed:8146159}. Nucleus envelope {ECO:0000269|PubMed:11854305, ECO:0000269|PubMed:15037602}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11854305}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11854305, ECO:0000269|PubMed:15037602}. Note=Cytoplasmic during interphase. Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602). Targeted to the nuclear pores after sumoylation (PubMed:11854305). During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602). Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305). Mitotic location also requires sumoylation (PubMed:11854305). {ECO:0000269|PubMed:11854305, ECO:0000269|PubMed:15037602}.
uniprot
proteins