CYP8B1
entrez
1582
canonical
uniprot
Q9UNU6
canonical
ensembl
ENSG00000180432
resolver
ensp
ENSP00000318867
resolver
enst
ENST00000316161
resolver
genesymbol
CYP8B1
resolver
genesymbol_syn
CYP12
resolver
hgnc
HGNC:2653
resolver
uniprot
B2RCY3
resolver
uniprot
O75958
resolver
uniprot
Q6NWT2
resolver
uniprot
Q6NWT3
resolver
uniprot_entry
CP8B1_HUMAN
resolver
uniprot_sec
B2RCY3
resolver
uniprot_sec
O75958
resolver
uniprot_sec
Q6NWT2
resolver
uniprot_sec
Q6NWT3
resolver
amino_acid_sequence
MVLWGPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRMRTKHGDVFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDHEMIHSASTKHLRGDGLKDLNETMLDSLSFVMLTSKGWSLDASCWHEDSLFRFCYYILFTAGYLSLFGYTKDKEQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVGRLQRLFHKMLSVSHSQEKEGISNWLGNMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALLYLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNPNGSRKVDFFKTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVDPQRWGFGTMQPSHDVRFRYRLHPTE
uniprot
proteins
ec_number
1.14.14.139
uniprot
proteins
function
FUNCTION: Sterol 12-alpha-hydroxylase involved in primary bile acid biosynthesis by catalyzing the 12alpha-hydroxylation of key intermediates including 7alpha-hydroxycholest-4-en-3-one, 3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate and chenodeoxycholate along the classic pathway (PubMed:10051404, PubMed:30465713, PubMed:39214664). May also hydroxylate 5beta-cholestane-3alpha,7alpha-diol (By similarity). Functions as a monooxygenase, inserting one atom of molecular oxygen into substrates while reducing the second to water, using electrons supplied by NADPH via cytochrome P450 reductase (CPR) (By similarity). Controls biliary balance of cholic acid and chenodeoxycholic acid, thereby regulating intestinal absorption of dietary lipids (By similarity). {ECO:0000250|UniProtKB:O02766, ECO:0000250|UniProtKB:O88962, ECO:0000269|PubMed:10051404, ECO:0000269|PubMed:30465713, ECO:0000269|PubMed:39214664}.
uniprot
proteins
mass_dalton
58068
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; bile acid biosynthesis. {ECO:0000250|UniProtKB:O88962}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10051404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30465713
uniprot
proteins
pubmed
39214664
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O02766}; Single-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:O02766}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 1..21; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins