Atp6v1f
entrez
66144
canonical
uniprot
Q9D1K2
canonical
ensembl
ENSMUSG00000004285
resolver
ensp
ENSMUSP00000004396
resolver
enst
ENSMUST00000004396
resolver
genesymbol
Atp6v1f
resolver
genesymbol_syn
Atp6s14
resolver
genesymbol_syn
Vatf
resolver
uniprot
Q3U6X0
resolver
uniprot_entry
VATF_MOUSE
resolver
uniprot_sec
Q3U6X0
resolver
amino_acid_sequence
MAGRGKLIAVIGDEDTVTGFLLGGIGELNKNRHPNFLVVEKDTTINEIEDTFRQFLNRDDIGIILINQYIAEMVRHALDAHQRSIPAVLEIPSKEHPYDAAKDSILRRAKGMFTAEDLR
uniprot
proteins
function
FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). {ECO:0000250|UniProtKB:Q16864, ECO:0000250|UniProtKB:Q28029}.
uniprot
proteins
mass_dalton
13370
uniprot
proteins
protein_family
V-ATPase F subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
119
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P50408}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P50408}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins