Pik3r6
entrez
104709
canonical
uniprot
Q3U6Q4
canonical
ensembl
ENSMUSG00000046207
resolver
ensp
ENSMUSP00000052522
resolver
ensp
ENSMUSP00000099673
resolver
ensp
ENSMUSP00000196877
resolver
genesymbol
Pik3r6
resolver
uniprot
Q3TBT5
resolver
uniprot
Q3UAY4
resolver
uniprot
Q8K323
resolver
uniprot_entry
PI3R6_MOUSE
resolver
uniprot_sec
Q3TBT5
resolver
uniprot_sec
Q3UAY4
resolver
uniprot_sec
Q8K323
resolver
amino_acid_sequence
MESSDVELDFQRSVQAVLRELNTPNPALQSNQGMWRWSLHKKVERNPGKSSILVRILLRELEKAESEDGRRVIIPLLLTLMSVLTKATGIPEDLYHRAYTFCTRLLTLPAPYSTVALDCAIRLKTETAVPGTLYQRTVIAEQNLISELYPYQERVFLFVDPELVSASVCSALLLEIQAAQEQQTPEACMRHVVSHALQAALGEACHTGALNRKLQASSRRVLEYYFHAVVAAIEQVASEDSPSRLGHLEKMEEIYCSLLGPATTRRHCVGDLLQDRLPSIPLPSPYITFHLWTDQEQLWKELVLFLRPRSQLRLSADLDALDLQGFRLDRDLARVSTDSGIERDLPLGSDELPDPSSSEMERAALQRKGGIKKRVWPPDFFMPGSWDGPPGLHRRTGRPSGDGELLPGVSRVHTARVLVLGDDRMLGRLAQAYYRLRKRETKKFCLTPRLSLQLYYIPVLAPQVTGQDPEASRKPELGELASFLGRVDPWYESTVNTLCPAILKLAEMPPYLDTSRTVDPFILDVITYYVRMGTQPIYFQLYKVKIFTSLSHDPTEDIFLTELKVKIQDSKSPKEGSSPRRRGAAEGTGAELSMCYQKALLSHRPREVTVSLRATGLVLKAIPAGDTEVSGFFHCTSPNAASATDCSCLHVSVTEVVKSSNLAGRSFTTSTNTFRTSSIQVQSQDQRLLTLWLDKDGRRTFRDVVRFEVSPCPEPCSRTQKSKTSALNSHGQETEKNMAKPNSLLMPINTFSGIIQ
uniprot
proteins
function
FUNCTION: Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G proteins than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. {ECO:0000269|PubMed:15797027, ECO:0000269|PubMed:16476736, ECO:0000269|PubMed:19906996}.
uniprot
proteins
mass_dalton
84663
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15797027
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16476736
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19906996
uniprot
proteins
sequence_length
756
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16476736}. Cell membrane {ECO:0000269|PubMed:19906996}; Peripheral membrane protein {ECO:0000269|PubMed:19906996}. Note=Translocated to the plasma membrane in a Ras-dependent manner (PubMed:19906996). {ECO:0000269|PubMed:19906996}.
uniprot
proteins