GPR45
entrez
11250
canonical
uniprot
Q9Y5Y3
canonical
ensembl
ENSG00000135973
resolver
ensp
ENSP00000258456
resolver
enst
ENST00000258456
resolver
genesymbol
GPR45
resolver
hgnc
HGNC:4503
resolver
uniprot
B5B0C1
resolver
uniprot
Q6NWS4
resolver
uniprot
Q6NXU6
resolver
uniprot_entry
B5B0C1_HUMAN
resolver
uniprot_entry
GPR45_HUMAN
resolver
uniprot_sec
Q6NWS4
resolver
uniprot_sec
Q6NXU6
resolver
amino_acid_sequence
MACNSTSLEAYTYLLLNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELLPQTFQILPKVPERIRRRIQPSTVYVCNENQSAV
uniprot
proteins
function
FUNCTION: Protein carrier that acts as a regulator of food intake in the paraventricular nucleus of the hypothalamus (PVH) by mediating transport of G(s) into primary cilia (By similarity). Transported into primary cilia of PVH neurons via its association with TULP3 and carries G(s) into the primary cilia to support MC4R activity and activate ADCY3, leading to cAMP production, which signals to suppress appetite (By similarity). Does not act as a canonical G protein-coupled receptor: does not promote the exchange of GDP for GTP on G(s) protein but mediates G(s) translocation into primary cilia (By similarity). {ECO:0000250|UniProtKB:Q9EQQ4}.
uniprot
proteins
mass_dalton
41967
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10036181
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16959974
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9EQQ4}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q9EQQ4}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 76..96; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 199..219; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 306..326; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins