Fbxo6
entrez
50762
canonical
uniprot
Q9QZN4
canonical
ensembl
ENSMUSG00000055401
resolver
ensp
ENSMUSP00000030858
resolver
ensp
ENSMUSP00000062348
resolver
ensp
ENSMUSP00000101331
resolver
ensp
ENSMUSP00000130188
resolver
ensp
ENSMUSP00000237387
resolver
enst
ENSMUST00000030858
resolver
enst
ENSMUST00000056965
resolver
enst
ENSMUST00000105706
resolver
enst
ENSMUST00000168503
resolver
genesymbol
Fbxo6
resolver
genesymbol_syn
Fbs2
resolver
genesymbol_syn
Fbxo6b
resolver
uniprot
A2A7H0
resolver
uniprot
A2A7H2
resolver
uniprot
B2KFL0
resolver
uniprot
B2KFL2
resolver
uniprot
Q3TML5
resolver
uniprot
Q3UCB0
resolver
uniprot_entry
FBX6_MOUSE
resolver
uniprot_sec
A2A7H0
resolver
uniprot_sec
A2A7H2
resolver
uniprot_sec
B2KFL0
resolver
uniprot_sec
B2KFL2
resolver
uniprot_sec
Q3TML5
resolver
uniprot_sec
Q3UCB0
resolver
amino_acid_sequence
MVHINELPENILLELFIHIPAPQLLRNCRLVCRLWRDLIDVVSLWKRKSLREGFFTKDRCEPVEDWKVFYILCSLQRNLLRNPCAEENLSSWRIDSNGGDRWKVETLPGSCGTSFPDNKVKKYFVTSFEMCLKSQMVDLKAEGYCEELMDTFRPDIVVKDWVAPRADCGCTYQLRVQLASADYIVLASFEPPPVTFQQWNDAKWQEISHTFSDYPPGVRHILFQHGGQDTQFWKGWYGPRVTNSSIIISHRTAKNPPPARTLPEETVVIGRRRRASDSNTHEGFFWQGLWQRLRR
uniprot
proteins
function
FUNCTION: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to ensure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. {ECO:0000250, ECO:0000269|PubMed:12939278, ECO:0000269|PubMed:15723043}.
uniprot
proteins
mass_dalton
34493
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
10531037
uniprot
proteins
pubmed
12939278
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15723043
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18203720
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins