POU3F2
entrez
5454
canonical
uniprot
P20265
canonical
ensembl
ENSG00000184486
resolver
ensp
ENSP00000329170
resolver
genesymbol
POU3F2
resolver
genesymbol_syn
BRN2
resolver
genesymbol_syn
OCT7
resolver
genesymbol_syn
OTF7
resolver
hgnc
HGNC:9215
resolver
uniprot
Q14960
resolver
uniprot
Q86V54
resolver
uniprot
Q9UJL0
resolver
uniprot_entry
PO3F2_HUMAN
resolver
uniprot_sec
Q14960
resolver
uniprot_sec
Q86V54
resolver
uniprot_sec
Q9UJL0
resolver
amino_acid_sequence
MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ
uniprot
proteins
function
FUNCTION: Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity). {ECO:0000250|UniProtKB:P31360, ECO:0000250|UniProtKB:P56222}.
uniprot
proteins
mass_dalton
46893
uniprot
proteins
protein_family
Class-3 subfamily
uniprot
proteins
protein_family
POU transcription factor family
uniprot
proteins
pubmed
10332029
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2739723
uniprot
proteins
pubmed
7651733
uniprot
proteins
pubmed
8441633
uniprot
proteins
sequence_length
443
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins