Cadps
entrez
27062
canonical
uniprot
Q80TJ1
canonical
ensembl
ENSMUSG00000054423
resolver
ensp
ENSMUSP00000064706
resolver
ensp
ENSMUSP00000108277
resolver
ensp
ENSMUSP00000247833
resolver
ensp
ENSMUSP00000247834
resolver
ensp
ENSMUSP00000247836
resolver
ensp
ENSMUSP00000247837
resolver
ensp
ENSMUSP00000247838
resolver
ensp
ENSMUSP00000247839
resolver
ensp
ENSMUSP00000247840
resolver
ensp
ENSMUSP00000247841
resolver
ensp
ENSMUSP00000247842
resolver
ensp
ENSMUSP00000247843
resolver
ensp
ENSMUSP00000247844
resolver
ensp
ENSMUSP00000247846
resolver
ensp
ENSMUSP00000247849
resolver
ensp
ENSMUSP00000247850
resolver
ensp
ENSMUSP00000247851
resolver
ensp
ENSMUSP00000247854
resolver
ensp
ENSMUSP00000247855
resolver
genesymbol
Cadps
resolver
genesymbol_syn
Caps
resolver
genesymbol_syn
Caps1
resolver
genesymbol_syn
Kiaa1121
resolver
uniprot
E9QN90
resolver
uniprot
Q3TSP2
resolver
uniprot
Q61374
resolver
uniprot
Q6AXB4
resolver
uniprot
Q6PGF0
resolver
uniprot_entry
CAPS1_MOUSE
resolver
uniprot_sec
E9QN90
resolver
uniprot_sec
Q3TSP2
resolver
uniprot_sec
Q61374
resolver
uniprot_sec
Q6AXB4
resolver
uniprot_sec
Q6PGF0
resolver
amino_acid_sequence
MLDPSSSEEESDEILEEERGKDVLGSAASGARLSPSRTSEGSAGSAGMGGSGAGAGVGAGGGGGSGASSGGGAGGLQPSSRAGGGRPSSPSPSVVSEKEKEELERLQKEEEERKKRLQLYVFVMRCIAYPFNAKQPTDMARRQQKISKQQLQTVKDRFQAFLNGETQIVADEAFMNAVQSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVRSLPEIDGLSKETVLSSWMAKFDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGRLQMADQIARERKFPKFVSKEMENMYIEELKSSVNLLMANLESMPVSKGGEFKLQKLKRSHNASIIDMGEESENQLSKSDVLLSFSLEVVIMEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEASKPTWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQSEWHKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWTIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTDPQPGLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNAKGGNVPQLDAPISQFSGLKDADRAQKHGMDEFISSNPCNFDHASLFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVHGNRPDGIGTVTVEEKERFEEIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYSRLSEYAKIEENQKDAENVGRLITPAKKLEDTIRLAELVIEVLQQNEEHHAEPHVDKGEAFAWWSDLMVEHAETFLSLFAVDMDAALEVQPPDTWDSFPLFQLLNDFLRTDYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVKSLTSNLPNVNLPNVNLPKVPNLPVNIPLGIPQMPTFSAPSWMAAIYDADNGSGTSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSRSTDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYDEGTLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQWYNSSMNIICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQGVLDSTLNSKTYETIRNRLTVEEATASVSEGGGLQGISMKDSDEEDEEDD
uniprot
proteins
function
FUNCTION: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). {ECO:0000250, ECO:0000269|PubMed:15820695}.
uniprot
proteins
mass_dalton
153113
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
14530279
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15820687
uniprot
proteins
pubmed
15820695
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17984325
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000269|PubMed:14530279}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000250|UniProtKB:Q62717}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62717}. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to dense core vesicles but not to synaptic vesicles. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2. {ECO:0000269|PubMed:14530279, ECO:0000269|PubMed:15820695}.
uniprot
proteins