P0DSE1
uniprot
P0DSE1
canonical
amino_acid_sequence
MVLKFSVSILWIQLAWVSTQLLEQSPQFLSIQEGENLTVYCNSSSVFSSLQWYRQEPGEGPVLLVTVVTGGEVKKLKRLTFQFGDARKDSSLHITAAQPGDTGLYLCAGGGSQGNLIFGKGTKLSVKPIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLSVIGFRILLLKVAGFNLLMTLRLWSS
uniprot
proteins
function
FUNCTION: The alpha chain of TRAV27*01J42*01C*01/TRBV19*01J2S7*01C*02 alpha-beta T cell receptor (TR) clonotype that is specific for HLA-A*02:01-restricted M/matrix protein 1 immunodominant epitope GILGFVFTL of influenza A virus (IAV). Classified as a public TR clonotype, it is preferentially selected in effector memory CD8-positive T cells among multiple HLA-A*02:01 carriers and confers long-lived immunity against IAV infection. Can cross-recognize sporadically emerging IAV variants by molecular mimicry, inducing immunity toward different influenza strains (PubMed:12796775, PubMed:18275829, PubMed:1833769, PubMed:27036003, PubMed:29997621, PubMed:7807026). Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity). {ECO:0000250|UniProtKB:P01848, ECO:0000269|PubMed:12796775, ECO:0000269|PubMed:18275829, ECO:0000269|PubMed:1833769, ECO:0000269|PubMed:27036003, ECO:0000269|PubMed:29997621, ECO:0000269|PubMed:7807026}.
uniprot
proteins
mass_dalton
29608
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="S->A: Decreases the affinity for M/matrix protein 1 peptide antigen."; /evidence="ECO:0000269|PubMed:18275829"; MUTAGEN 49; /note="S->A: Decreases the affinity for M/matrix protein 1 peptide antigen."; /evidence="ECO:0000269|PubMed:18275829"; MUTAGEN 51; /note="Q->A: Decreases the affinity for M/matrix protein 1 peptide antigen."; /evidence="ECO:0000269|PubMed:18275829
uniprot
proteins
pubmed
11096259
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12796775
uniprot
proteins
pubmed
18275829
uniprot
proteins
pubmed
1833769
uniprot
proteins
pubmed
19568742
uniprot
proteins
pubmed
27036003
uniprot
proteins
pubmed
29997621
uniprot
proteins
pubmed
3875483
uniprot
proteins
pubmed
7807026
uniprot
proteins
pubmed
8550091
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29997621}.
uniprot
proteins
transmembrane_region
TRANSMEM 244..266; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins