COPS3
entrez
8533
canonical
uniprot
Q9UNS2
canonical
ensembl
ENSG00000141030
resolver
ensp
ENSP00000268717
resolver
ensp
ENSP00000437606
resolver
ensp
ENSP00000646797
resolver
genesymbol
COPS3
resolver
genesymbol_syn
CSN3
resolver
hgnc
HGNC:2239
resolver
uniprot
B2R683
resolver
uniprot
B4DN01
resolver
uniprot
B4DY81
resolver
uniprot
O43191
resolver
uniprot
Q7LDR6
resolver
uniprot_entry
B4DN01_HUMAN
resolver
uniprot_entry
CSN3_HUMAN
resolver
uniprot_sec
B2R683
resolver
uniprot_sec
B4DY81
resolver
uniprot_sec
O43191
resolver
uniprot_sec
Q7LDR6
resolver
amino_acid_sequence
MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSIHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS
uniprot
proteins
function
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (PubMed:28891468). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (PubMed:28891468). {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:28891468, ECO:0000269|PubMed:9535219}.
uniprot
proteins
mass_dalton
47873
uniprot
proteins
protein_family
CSN3 family
uniprot
proteins
pubmed
10191102
uniprot
proteins
pubmed
11285227
uniprot
proteins
pubmed
11337588
uniprot
proteins
pubmed
11418127
uniprot
proteins
pubmed
12220626
uniprot
proteins
pubmed
12628923
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12732143
uniprot
proteins
pubmed
12917637
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15325100
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18850735
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26030138
uniprot
proteins
pubmed
26456823
uniprot
proteins
pubmed
28891468
uniprot
proteins
pubmed
9535219
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28891468, ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}. Cell junction {ECO:0000269|PubMed:28891468}.
uniprot
proteins