Prkab1
entrez
19079
canonical
uniprot
Q9R078
canonical
ensembl
ENSMUSG00000029513
resolver
ensp
ENSMUSP00000031486
resolver
ensp
ENSMUSP00000107630
resolver
enst
ENSMUST00000031486
resolver
enst
ENSMUST00000111999
resolver
genesymbol
Prkab1
resolver
uniprot
Q542K0
resolver
uniprot
Q91YN6
resolver
uniprot_entry
AAKB1_MOUSE
resolver
uniprot_entry
Q542K0_MOUSE
resolver
uniprot_sec
Q91YN6
resolver
amino_acid_sequence
MGNTSSERAALERQAGHKTPRRDSSGGAKDGDRPKILMDSPEDADIFHSEEIKAPEKEEFLAWQHDLEANDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSQNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYMSKPEERFKAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
30308
uniprot
proteins
post_translational_modification
PTM: Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK. {ECO:0000269|PubMed:21460634}.
uniprot
proteins
protein_family
5'-AMP-activated protein kinase beta subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21460634
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
26359501
uniprot
proteins
sequence_length
270
uniprot
proteins