Atxn7l3b
entrez
382423
canonical
uniprot
Q3UD01
canonical
ensembl
ENSMUSG00000074748
resolver
ensp
ENSMUSP00000096882
resolver
enst
ENSMUST00000099276
resolver
genesymbol
Atxn7l3b
resolver
uniprot_entry
A7L3B_MOUSE
resolver
amino_acid_sequence
MEEISLANLDTNKLEAIAQEIYVDLIEDSCLGFCFEVHRAVKCGYFYLEFADTGSVKDFGIQPVEDKGACRLPLCSLPGDPGDGPQTELQRSPPEFQ
uniprot
proteins
function
FUNCTION: By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3. {ECO:0000250|UniProtKB:Q96GX2}.
uniprot
proteins
mass_dalton
10731
uniprot
proteins
protein_family
SGF11 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16680195
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
97
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96GX2}.
uniprot
proteins