HTATIP2
entrez
10553
canonical
uniprot
Q9BUP3
canonical
ensembl
ENSG00000109854
resolver
ensp
ENSP00000387876
resolver
ensp
ENSP00000392985
resolver
ensp
ENSP00000394259
resolver
ensp
ENSP00000397752
resolver
ensp
ENSP00000432107
resolver
genesymbol
HTATIP2
resolver
genesymbol_syn
CC3
resolver
genesymbol_syn
TIP30
resolver
hgnc
HGNC:16637
resolver
uniprot
A8K7S7
resolver
uniprot
D3DQY8
resolver
uniprot
O15383
resolver
uniprot
O60520
resolver
uniprot
O95345
resolver
uniprot
Q53GC1
resolver
uniprot
Q53GG2
resolver
uniprot
Q6IBI3
resolver
uniprot_entry
HTAI2_HUMAN
resolver
uniprot_sec
A8K7S7
resolver
uniprot_sec
D3DQY8
resolver
uniprot_sec
O15383
resolver
uniprot_sec
O60520
resolver
uniprot_sec
O95345
resolver
uniprot_sec
Q53GC1
resolver
uniprot_sec
Q53GG2
resolver
uniprot_sec
Q6IBI3
resolver
amino_acid_sequence
MAETEALSKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEEAYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRGKAGAEGFVRVDRDYVLKSAELAKAGGCKHFNLLSSKGADKSSNFLYLQVKGEVEAKVEELKFDRYSVFRPGVLLCDRQESRPGEWLVRKFFGSLPDSWASGHSVPVVTVVRAMLNNVVRPRDKQMELLENKAIHDLGKAHGSLKP
uniprot
proteins
function
FUNCTION: Represses translation by preventing reactivation of elongation factor eEF1A (By similarity). May also inhibit nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors (PubMed:15282309). Has additionally been proposed to act as a redox sensor involved in cellular oxidative stress surveillance (PubMed:18519672). {ECO:0000250|UniProtKB:B0BNF8, ECO:0000269|PubMed:15282309, ECO:0000269|PubMed:18519672}.
uniprot
proteins
mass_dalton
27049
uniprot
proteins
mutagenesis
MUTAGEN 28..31; /note="GETG->VETA: Loss of proapoptotic and metastatis-inhibiting effect."; /evidence="ECO:0000269|PubMed:10698937"; MUTAGEN 106; /note="R->H: Loss of association with nucleus."; /evidence="ECO:0000269|PubMed:14695192
uniprot
proteins
pubmed
10611237
uniprot
proteins
pubmed
10698937
uniprot
proteins
pubmed
14695192
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15073177
uniprot
proteins
pubmed
15282309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15728189
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18519672
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24237036
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
31468715
uniprot
proteins
pubmed
9174052
uniprot
proteins
pubmed
9482853
uniprot
proteins
sequence_length
242
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15282309}.
uniprot
proteins