Bpifa1
entrez
246238
canonical
uniprot
Q8K4I4
canonical
ensembl
ENSRNOG00000013859
resolver
ensembl
ENSRNOG00055025991
resolver
ensembl
ENSRNOG00060023651
resolver
ensembl
ENSRNOG00065025036
resolver
ensp
ENSRNOP00000018581
resolver
ensp
ENSRNOP00000102338
resolver
ensp
ENSRNOP00055036753
resolver
ensp
ENSRNOP00060033904
resolver
ensp
ENSRNOP00065035255
resolver
enst
ENSRNOT00000018581
resolver
enst
ENSRNOT00000138935
resolver
enst
ENSRNOT00055044853
resolver
enst
ENSRNOT00060040970
resolver
enst
ENSRNOT00065043056
resolver
genesymbol
Bpifa1
resolver
genesymbol_syn
Plunc
resolver
uniprot
A0ABK0LLN3
resolver
uniprot_entry
A0ABK0LLN3_RAT
resolver
uniprot_entry
BPIA1_RAT
resolver
amino_acid_sequence
MFLVGSLVVLCGLLAQSTAQLAGLPLPLGQGLPLPLGQGLPLPLGQGLPLAVSPALPSNPTDLLAGNFANALSGGLLSGGLLGILENIPLLDVIKSGGGSSNGLVGGLLGKLTSSVPLLNNILDIKITDPRLLELGLVQSPDGHRLYATIPLSLKLQVNMPVVGSFLQLAVKLNITAEIVAMKDNQGRIHLVLGDCTHSPGSLQITLLNGVTPVQSSLDSLTGILTKVLPELIQGKVCPLINGILSGLDVTLVHNIAELLIHGIQFVIKV
uniprot
proteins
function
FUNCTION: Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. {ECO:0000250|UniProtKB:Q9NP55}.
uniprot
proteins
mass_dalton
27719
uniprot
proteins
protein_family
BPI/LBP/Plunc superfamily
uniprot
proteins
protein_family
Plunc family
uniprot
proteins
pubmed
11821380
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11821380}. Note=Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.
uniprot
proteins