SIVA1
entrez
10572
canonical
uniprot
O15304
canonical
ensembl
ENSG00000184990
resolver
ensp
ENSP00000329213
resolver
ensp
ENSP00000329447
resolver
ensp
ENSP00000768225
resolver
genesymbol
SIVA1
resolver
genesymbol_syn
SIVA
resolver
hgnc
HGNC:17712
resolver
uniprot
Q96P98
resolver
uniprot
Q9UPD6
resolver
uniprot_entry
SIVA_HUMAN
resolver
uniprot_sec
Q96P98
resolver
uniprot_sec
Q9UPD6
resolver
amino_acid_sequence
MPKRSCPFADVAPLQLKVRVSQRELSRGVCAERYSQEVFEKTKRLLFLGAQAYLDHVWDEGCAVVHLPESPKPGPTGAPRAARGQMLIGPDGRLIRSLGQASEADPSGVASIACSSCVRAVDGKAVCGQCERALCGQCVRTCWGCGSVACTLCGLVDCSDMYEKVLCTSCAMFET
uniprot
proteins
function
FUNCTION: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. {ECO:0000269|PubMed:12011449, ECO:0000269|PubMed:14739602, ECO:0000269|PubMed:15034012, ECO:0000269|PubMed:15958577, ECO:0000269|PubMed:16491128}.
uniprot
proteins
mass_dalton
18695
uniprot
proteins
mutagenesis
MUTAGEN 34; /note="Y->F: Abolishes phosphorylation and apoptotic activity."; /evidence="ECO:0000269|PubMed:11278261"; MUTAGEN 53; /note="Y->F: No effect on phosphorylation or apoptotic activity."; /evidence="ECO:0000269|PubMed:11278261
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ABL2/ARG in response to oxidative stress. {ECO:0000269|PubMed:11278261}.
uniprot
proteins
pubmed
10756043
uniprot
proteins
pubmed
11278261
uniprot
proteins
pubmed
11601913
uniprot
proteins
pubmed
12011449
uniprot
proteins
pubmed
14739602
uniprot
proteins
pubmed
15034012
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15958577
uniprot
proteins
pubmed
16491128
uniprot
proteins
pubmed
16683188
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9177220
uniprot
proteins
sequence_length
175
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15034012}. Nucleus {ECO:0000269|PubMed:15034012}. Note=In the nucleus, accumulates in dot-like structures.
uniprot
proteins