Dppa3
entrez
297576
canonical
uniprot
Q6IMK0
canonical
ensembl
ENSRNOG00000022950
resolver
ensembl
ENSRNOG00000031344
resolver
ensembl
ENSRNOG00000084024
resolver
ensembl
ENSRNOG00055003667
resolver
ensembl
ENSRNOG00055011569
resolver
ensembl
ENSRNOG00060025081
resolver
ensembl
ENSRNOG00060029883
resolver
ensembl
ENSRNOG00065028171
resolver
ensembl
ENSRNOG00065033144
resolver
ensp
ENSRNOP00000036033
resolver
ensp
ENSRNOP00000090420
resolver
ensp
ENSRNOP00000106364
resolver
ensp
ENSRNOP00055004330
resolver
ensp
ENSRNOP00055015848
resolver
ensp
ENSRNOP00060035941
resolver
ensp
ENSRNOP00060043152
resolver
ensp
ENSRNOP00065039791
resolver
ensp
ENSRNOP00065046940
resolver
enst
ENSRNOT00000031353
resolver
enst
ENSRNOT00000049192
resolver
enst
ENSRNOT00000150860
resolver
enst
ENSRNOT00055005755
resolver
enst
ENSRNOT00055019653
resolver
enst
ENSRNOT00060043389
resolver
enst
ENSRNOT00060051890
resolver
enst
ENSRNOT00065048527
resolver
enst
ENSRNOT00065057017
resolver
genesymbol
Dppa3
resolver
genesymbol_syn
Stella
resolver
uniprot_entry
DPPA3_RAT
resolver
amino_acid_sequence
MDEPSEKVDPVVNPETQMYDGSQREDEGDSPDDSEILQPETLVKVMKKLTLNPSAKPTKYHRRQRVRLQVKSQPVENRSERIMREVQSAFPRRRVRTLLSVLKDPIARMRRFVRIEQRQRQLEGNERRDEPFRCLCTFCHYQRWDPSENAKIGQNQKN
uniprot
proteins
function
FUNCTION: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis. {ECO:0000250|UniProtKB:Q8QZY3}.
uniprot
proteins
mass_dalton
18834
uniprot
proteins
pubmed
14654002
uniprot
proteins
sequence_length
158
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8QZY3}. Cytoplasm {ECO:0000250|UniProtKB:Q8QZY3}. Note=Mainly localizes in the female pronucleus, localization to the male pronucleus in much weaker. {ECO:0000250|UniProtKB:Q8QZY3}.
uniprot
proteins