Krt8
entrez
25626
canonical
uniprot
Q10758
canonical
ensembl
ENSRNOG00000009779
resolver
ensembl
ENSRNOG00055026530
resolver
ensembl
ENSRNOG00060014071
resolver
ensembl
ENSRNOG00065019903
resolver
ensp
ENSRNOP00000029068
resolver
ensp
ENSRNOP00055037538
resolver
ensp
ENSRNOP00060019201
resolver
ensp
ENSRNOP00065026848
resolver
enst
ENSRNOT00000038480
resolver
enst
ENSRNOT00055045792
resolver
enst
ENSRNOT00060024083
resolver
enst
ENSRNOT00065033542
resolver
genesymbol
Krt8
resolver
genesymbol_syn
Krt2-8
resolver
uniprot
Q5WPB3
resolver
uniprot_entry
K2C8_RAT
resolver
uniprot_sec
Q5WPB3
resolver
amino_acid_sequence
MSVRVTQKSYKMSTSGPRAFSSRSFTSGPGARISSSSFSRVGSSSSSFRGSLGGFGGAGVGGITAVTVNQSLLNPLKLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTSRSNMDNMFESYINNLRRQLEALGQEKLKLEVELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQIHEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVRAQYEEIANRSRAEAETMYQIKYEELQTLAGKHGDDLRRSKTEISEMNRNISRLQAEIDALKGQRATLEAAIADAEQRGELAVKDANAKLEDLKNALQKAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLSSSYGGLTSPGFSYGMSSFQPGFGSVGGSSTYSRTKAVVVKKIETRDGKLVSESSDIMSK
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in simple epithelial cells. Together with its obligate type I partner KRT18, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to epithelial cells (PubMed:1691189). Also involved in maintaining epithelial integrity and protecting cells from non-mechanical stress, such as apoptosis (By similarity). Also required for ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement (By similarity). In striated muscle, together with KRT19, may contribute to linking the contractile apparatus to dystrophin at the costameres (PubMed:15247274). {ECO:0000250|UniProtKB:P05787, ECO:0000250|UniProtKB:P11679, ECO:0000269|PubMed:15247274, ECO:0000269|PubMed:1691189}.
uniprot
proteins
mass_dalton
54019
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation (By similarity). {ECO:0000250}.; PTM: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. {ECO:0000250}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
1370816
uniprot
proteins
pubmed
15247274
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16128803
uniprot
proteins
pubmed
16396499
uniprot
proteins
pubmed
1691189
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7525090
uniprot
proteins
pubmed
8660345
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16128803}. Nucleus, nucleoplasm {ECO:0000269|PubMed:16128803}. Nucleus matrix {ECO:0000269|PubMed:16128803}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P05787}.
uniprot
proteins