Kank2
entrez
235041
canonical
uniprot
Q8BX02
canonical
ensembl
ENSMUSG00000032194
resolver
ensp
ENSMUSP00000034717
resolver
genesymbol
Kank2
resolver
genesymbol_syn
Ankrd25
resolver
uniprot
Q8BLD5
resolver
uniprot
Q91Z35
resolver
uniprot_entry
KANK2_MOUSE
resolver
uniprot_sec
Q8BLD5
resolver
uniprot_sec
Q91Z35
resolver
amino_acid_sequence
MAQVLHVPAPFPGTPGQASPAAFPSKEPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPRLGSLPRGPGSWWTSTESLCSDASGDSRHSAYSYCGRGFYPQYGALETRIGSNPRVERTLLDARRRLEDQAAAPSSGGLGSLTPSAAGSTSSLAGVGLLPPTPRSSGLSTPVAPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPSGTRSRSELCLDLPEAPDDPAALETRSVGTWVRERDLGIPDGEAALVAKVAVLETQLKKALQELRAAQTQQVDLQPQAWPPPDTQVRVDTVRVVEGPREVEVAASTAAGALAQRAQSLEPYGTGLKALTTSGGPENTLVFRSHEVVETMCPLPTATTGNVHTAKKISITERSCTGAPRMTEPSSVNPRPAAASVVQPENPVPAAQDTTDKKPTRPAAASQDSQAADGAGRASLATKRKEDPADPEVNQRNLQFVGVNGGYESPSEDSSTAENSEHESTENEGPEPPARVLSPAECPQLRPPGAAVATTSLEGPQLSQESQRVPAPEVASGPDPEEEIRMDLSPDLISACLALEKYLENPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVCHVDKLNRAGYSPIMLTALATLKTQDDIETILQLFRLGNVNAKASQAGQTALMLAVSHGRVDVVRALLACEADVNIQDEDGSTALMCACEHGHKEITGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSDYESPASSSAEE
uniprot
proteins
function
FUNCTION: Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (PubMed:16024821). {ECO:0000250|UniProtKB:Q63ZY3, ECO:0000269|PubMed:16024821, ECO:0000269|PubMed:25961457}.
uniprot
proteins
mass_dalton
90245
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by casein kinase II upon estrogen stimulation (By similarity). Phosphorylation induces the release by KANK2 of NCOA1 and its translocation to the nucleus where NCOA1 can activate gene transcription (By similarity). {ECO:0000250|UniProtKB:Q63ZY3}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16024821
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
20720434
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
25961457
uniprot
proteins
sequence_length
843
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q63ZY3}. Mitochondrion {ECO:0000250|UniProtKB:Q63ZY3}.
uniprot
proteins