DCK
entrez
1633
canonical
uniprot
P27707
canonical
ensembl
ENSG00000156136
resolver
ensp
ENSP00000286648
resolver
enst
ENST00000286648
resolver
genesymbol
DCK
resolver
hgnc
HGNC:2704
resolver
uniprot
B2R8V6
resolver
uniprot
B4E0A5
resolver
uniprot
F5CTF3
resolver
uniprot
Q5TZY7
resolver
uniprot
Q6FI11
resolver
uniprot_entry
B4E0A5_HUMAN
resolver
uniprot_entry
DCK_HUMAN
resolver
uniprot_entry
F5CTF3_HUMAN
resolver
uniprot_sec
B2R8V6
resolver
uniprot_sec
Q5TZY7
resolver
uniprot_sec
Q6FI11
resolver
amino_acid_sequence
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL
uniprot
proteins
ec_number
2.7.1.113
uniprot
proteins
ec_number
2.7.1.74
uniprot
proteins
ec_number
2.7.1.76
uniprot
proteins
function
FUNCTION: Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:1996353, PubMed:20614893, PubMed:20637175). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445). {ECO:0000269|PubMed:12808445, ECO:0000269|PubMed:18377927, ECO:0000269|PubMed:19159229, ECO:0000269|PubMed:1996353, ECO:0000269|PubMed:20614893, ECO:0000269|PubMed:20637175}.
uniprot
proteins
mass_dalton
30519
uniprot
proteins
mutagenesis
MUTAGEN 74; /note="S->A: 4.5-fold increase in Km."; /evidence="ECO:0000269|PubMed:20637175"; MUTAGEN 100; /note="A->V: Strongly increased catalytic efficiency towards deoxycytidine; when associated with M-104 and A-133."; /evidence="ECO:0000269|PubMed:12808445"; MUTAGEN 104; /note="R->L: Strongly increased catalytic efficiency towards deoxythymidine; when associated with A-133."; /evidence="ECO:0000269|PubMed:12808445, ECO:0000269|PubMed:19159229, ECO:0000269|PubMed:20614893"; MUTAGEN 104; /note="R->M: Strongly increased catalytic efficiency towards deoxycytidine; when associated with V-100 and A-133."; /evidence="ECO:0000269|PubMed:12808445, ECO:0000269|PubMed:19159229, ECO:0000269|PubMed:20614893"; MUTAGEN 133; /note="D->A: Strongly increased catalytic efficiency towards deoxycytidine; when associated with V-100 and M-104. Strongly increased catalytic efficiency towards deoxythymidine; when associated with L-104."; /evidence="ECO:0000269|PubMed:12808445, ECO:0000269|PubMed:19159229, ECO:0000269|PubMed:20614893
uniprot
proteins
post_translational_modification
PTM: Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1. {ECO:0000269|PubMed:20637175}.
uniprot
proteins
protein_family
DCK/DGK family
uniprot
proteins
pubmed
12808445
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421443
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17530837
uniprot
proteins
pubmed
18377927
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19159229
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19836232
uniprot
proteins
pubmed
1996353
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
2013338
uniprot
proteins
pubmed
20614893
uniprot
proteins
pubmed
20637175
uniprot
proteins
pubmed
20684612
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9342341
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9342341}.
uniprot
proteins