EYA2
entrez
2139
canonical
uniprot
O00167
canonical
ensembl
ENSG00000064655
resolver
ensp
ENSP00000321590
resolver
ensp
ENSP00000333640
resolver
ensp
ENSP00000349986
resolver
ensp
ENSP00000483392
resolver
ensp
ENSP00000528594
resolver
enst
ENST00000317304
resolver
enst
ENST00000611592
resolver
genesymbol
EYA2
resolver
genesymbol_syn
EAB1
resolver
hgnc
HGNC:3520
resolver
uniprot
E7ETN2
resolver
uniprot
Q5JSW8
resolver
uniprot
Q86U84
resolver
uniprot
Q96CV6
resolver
uniprot
Q96H97
resolver
uniprot
Q99503
resolver
uniprot
Q99812
resolver
uniprot
Q9BWF6
resolver
uniprot
Q9H4S3
resolver
uniprot
Q9H4S9
resolver
uniprot
Q9NPZ4
resolver
uniprot
Q9UIX7
resolver
uniprot_entry
E7ETN2_HUMAN
resolver
uniprot_entry
EYA2_HUMAN
resolver
uniprot_sec
Q5JSW8
resolver
uniprot_sec
Q86U84
resolver
uniprot_sec
Q96CV6
resolver
uniprot_sec
Q96H97
resolver
uniprot_sec
Q99503
resolver
uniprot_sec
Q99812
resolver
uniprot_sec
Q9BWF6
resolver
uniprot_sec
Q9H4S3
resolver
uniprot_sec
Q9H4S9
resolver
uniprot_sec
Q9NPZ4
resolver
uniprot_sec
Q9UIX7
resolver
amino_acid_sequence
MVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVHQDYPSYPGFPQSQYPQYYGSSYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSESLAGEYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905). {ECO:0000269|PubMed:12500905, ECO:0000269|PubMed:19351884, ECO:0000269|PubMed:21706047, ECO:0000269|PubMed:23435380}.
uniprot
proteins
mass_dalton
59232
uniprot
proteins
mutagenesis
MUTAGEN 516; /note="P->R: Strongly reduces SIX1 binding."; /evidence="ECO:0000269|PubMed:23435380"; MUTAGEN 532; /note="A->R: Abolishes interaction with SIX1."; /evidence="ECO:0000269|PubMed:23435380
uniprot
proteins
protein_family
EYA family
uniprot
proteins
protein_family
HAD-like hydrolase superfamily
uniprot
proteins
pubmed
10906137
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12500905
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19351884
uniprot
proteins
pubmed
19497856
uniprot
proteins
pubmed
19858093
uniprot
proteins
pubmed
21706047
uniprot
proteins
pubmed
23435380
uniprot
proteins
pubmed
9020840
uniprot
proteins
pubmed
9049631
uniprot
proteins
pubmed
9195991
uniprot
proteins
pubmed
9887327
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10906137, ECO:0000269|PubMed:12500905}. Nucleus {ECO:0000269|PubMed:10906137, ECO:0000269|PubMed:12500905, ECO:0000269|PubMed:19497856}. Note=Retained in the cytoplasm via interaction with GNAZ and GNAI2 (PubMed:10906137). Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus (PubMed:10906137, PubMed:12500905). {ECO:0000269|PubMed:10906137, ECO:0000269|PubMed:12500905}.
uniprot
proteins