ADRB3
entrez
155
canonical
uniprot
P13945
canonical
ensembl
ENSG00000188778
resolver
ensp
ENSP00000343782
resolver
enst
ENST00000345060
resolver
genesymbol
ADRB3
resolver
genesymbol_syn
ADRB3R
resolver
genesymbol_syn
B3AR
resolver
hgnc
HGNC:288
resolver
uniprot
A8KAG8
resolver
uniprot
Q4JFT4
resolver
uniprot_entry
A8KAG8_HUMAN
resolver
uniprot_entry
ADRB3_HUMAN
resolver
uniprot_sec
Q4JFT4
resolver
amino_acid_sequence
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent pathway, respectively (PubMed:10188996, PubMed:2570461, PubMed:8641219). The rank order of potency for physiological agonists is norepinephrine > epinephrine (PubMed:10188996, PubMed:2570461, PubMed:8641219). Involved in the regulation of thermogenesis and lipolysis in brown and white adipose tissue, after coupling to G(s) proteins and stimulation of the cAMP-PKA axis (By similarity). Also activates lipolytic process by coupling to G(i) proteins and consequent initiation of the ERK1/2 MAP kinase cascade (PubMed:10207024). Participates in relaxation of the blood vessels and the urinary bladder (PubMed:10188996). Also mediates negative inotropic effects in cardiomyocytes through activation of an NO synthase pathway and subsequent increase in cGMP levels, possibly involving G(i/o) protein-mediated coupling (PubMed:9769330). {ECO:0000250|UniProtKB:P25962, ECO:0000269|PubMed:10188996, ECO:0000269|PubMed:10207024, ECO:0000269|PubMed:2570461, ECO:0000269|PubMed:8641219, ECO:0000269|PubMed:9769330}.
uniprot
proteins
mass_dalton
43519
uniprot
proteins
protein_family
ADRB3 sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10188996
uniprot
proteins
pubmed
10207024
uniprot
proteins
pubmed
10391210
uniprot
proteins
pubmed
1336117
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21982743
uniprot
proteins
pubmed
2570461
uniprot
proteins
pubmed
7609752
uniprot
proteins
pubmed
8389293
uniprot
proteins
pubmed
8389717
uniprot
proteins
pubmed
8641219
uniprot
proteins
pubmed
8721782
uniprot
proteins
pubmed
9769330
uniprot
proteins
sequence_length
408
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:O02662}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O02662"; TRANSMEM 74..100; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O02662"; TRANSMEM 109..133; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O02662"; TRANSMEM 154..174; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O02662"; TRANSMEM 203..223; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O02662"; TRANSMEM 295..318; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O02662"; TRANSMEM 322..344; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:O02662
uniprot
proteins