P22561
uniprot
P22561
canonical
amino_acid_sequence
MGSDVRDLNALLPAVSSLGGGGGGCGLPVSGARQWAPVLDFAPPGASAYGSLGGPAPPPAPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTLHFSGQFTGTAGACRYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPTIRNQGYSTVTFDGAPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGMAAGSSSSVKWTEGQSNHGIGYESENHTAPILCGAQYRIHTHGVFRGIQDVRRVSGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGKTSEKPFSCRWHSCQKKFARSDELVRHHNMHQRNMTKLHVAL
uniprot
proteins
function
FUNCTION: Transcription factor that plays an important role in cellular development and cell survival (PubMed:16467207, PubMed:16920711, PubMed:17537799). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity). Regulates the expression of numerous target genes, including EPO (PubMed:16467207). Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:17167543). Isoform 1 has lower affinity for DNA, and can bind RNA. {ECO:0000250|UniProtKB:P19544, ECO:0000269|PubMed:16467207, ECO:0000269|PubMed:16920711, ECO:0000269|PubMed:17167543, ECO:0000269|PubMed:17537799}.
uniprot
proteins
mass_dalton
49246
uniprot
proteins
protein_family
EGR C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
14681305
uniprot
proteins
pubmed
14736876
uniprot
proteins
pubmed
16467207
uniprot
proteins
pubmed
1671709
uniprot
proteins
pubmed
16920711
uniprot
proteins
pubmed
16924231
uniprot
proteins
pubmed
17167543
uniprot
proteins
pubmed
17537799
uniprot
proteins
pubmed
19457926
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8621495
uniprot
proteins
pubmed
9784496
uniprot
proteins
sequence_length
449
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus speckle.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus, nucleoplasm.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14681305}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:14681305}. Nucleus speckle. Note=Shuttles between nucleus and cytoplasm. {ECO:0000269|PubMed:14681305}.
uniprot
proteins