CAMK2G
entrez
818
canonical
uniprot
Q13555
canonical
ensembl
ENSG00000148660
resolver
ensp
ENSP00000277853
resolver
ensp
ENSP00000307082
resolver
ensp
ENSP00000315599
resolver
ensp
ENSP00000319060
resolver
ensp
ENSP00000361851
resolver
ensp
ENSP00000378243
resolver
ensp
ENSP00000393784
resolver
ensp
ENSP00000405561
resolver
ensp
ENSP00000410298
resolver
ensp
ENSP00000505103
resolver
ensp
ENSP00000514974
resolver
ensp
ENSP00000534166
resolver
ensp
ENSP00000534167
resolver
ensp
ENSP00000534168
resolver
ensp
ENSP00000534169
resolver
ensp
ENSP00000534170
resolver
ensp
ENSP00000534171
resolver
ensp
ENSP00000534172
resolver
ensp
ENSP00000534173
resolver
ensp
ENSP00000534174
resolver
ensp
ENSP00000534175
resolver
ensp
ENSP00000534178
resolver
ensp
ENSP00000534179
resolver
ensp
ENSP00000534180
resolver
ensp
ENSP00000534181
resolver
ensp
ENSP00000534185
resolver
ensp
ENSP00000534187
resolver
ensp
ENSP00000534188
resolver
ensp
ENSP00000534192
resolver
ensp
ENSP00000534198
resolver
ensp
ENSP00000534199
resolver
ensp
ENSP00000634886
resolver
ensp
ENSP00000634892
resolver
ensp
ENSP00000634896
resolver
ensp
ENSP00000670624
resolver
ensp
ENSP00000670625
resolver
ensp
ENSP00000670627
resolver
ensp
ENSP00000670628
resolver
ensp
ENSP00000709988
resolver
ensp
ENSP00000709989
resolver
ensp
ENSP00000710009
resolver
ensp
ENSP00000710028
resolver
ensp
ENSP00000710030
resolver
ensp
ENSP00000710031
resolver
ensp
ENSP00000710032
resolver
ensp
ENSP00000710034
resolver
enst
ENST00000322680
resolver
enst
ENST00000372765
resolver
enst
ENST00000423381
resolver
enst
ENST00000441192
resolver
enst
ENST00000864113
resolver
enst
ENST00000864139
resolver
enst
ENST00000964833
resolver
enst
ENST00000964837
resolver
genesymbol
CAMK2G
resolver
genesymbol_syn
CAMK
resolver
genesymbol_syn
CAMK-II
resolver
genesymbol_syn
CAMKG
resolver
hgnc
HGNC:1463
resolver
uniprot
A0A0A0MS52
resolver
uniprot
A0A0A0MT11
resolver
uniprot
A0A2Q3DQE3
resolver
uniprot
B3KY86
resolver
uniprot
H0Y6G2
resolver
uniprot
O00561
resolver
uniprot
O15378
resolver
uniprot
Q13279
resolver
uniprot
Q13280
resolver
uniprot
Q13282
resolver
uniprot
Q13556
resolver
uniprot
Q5SQZ3
resolver
uniprot
Q5SQZ4
resolver
uniprot
Q5SWX3
resolver
uniprot
Q5SWX4
resolver
uniprot
Q7KYX5
resolver
uniprot
Q8N4I3
resolver
uniprot
Q8NIA4
resolver
uniprot_entry
A0A2Q3DQE3_HUMAN
resolver
uniprot_entry
B3KY86_HUMAN
resolver
uniprot_entry
H0Y6G2_HUMAN
resolver
uniprot_entry
KCC2G_HUMAN
resolver
uniprot_entry
Q13280_HUMAN
resolver
uniprot_entry
Q5SWX3_HUMAN
resolver
uniprot_sec
A0A0A0MS52
resolver
uniprot_sec
A0A0A0MT11
resolver
uniprot_sec
O00561
resolver
uniprot_sec
O15378
resolver
uniprot_sec
Q13279
resolver
uniprot_sec
Q13282
resolver
uniprot_sec
Q13556
resolver
uniprot_sec
Q5SQZ3
resolver
uniprot_sec
Q5SQZ4
resolver
uniprot_sec
Q5SWX4
resolver
uniprot_sec
Q7KYX5
resolver
uniprot_sec
Q8N4I3
resolver
uniprot_sec
Q8NIA4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity. {ECO:0000269|PubMed:14722083}.
uniprot
proteins
amino_acid_sequence
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKGRVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, autosomal dominant 59 (MRD59) [MIM:618522]: An autosomal dominant form of intellectual disability, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269|PubMed:23033978, ECO:0000269|PubMed:30184290}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}.
uniprot
proteins
mass_dalton
62607
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state. {ECO:0000269|PubMed:14722083, ECO:0000269|PubMed:16690701}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
12032636
uniprot
proteins
pubmed
14722083
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15294044
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16690701
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20668654
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23033978
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30184290
uniprot
proteins
pubmed
7557101
uniprot
proteins
pubmed
8449910
uniprot
proteins
pubmed
9060999
uniprot
proteins
pubmed
9240463
uniprot
proteins
sequence_length
558
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
uniprot
proteins