INTS10
entrez
55174
canonical
uniprot
Q9NVR2
canonical
ensembl
ENSG00000104613
resolver
ensp
ENSP00000381064
resolver
ensp
ENSP00000554268
resolver
ensp
ENSP00000596916
resolver
ensp
ENSP00000655448
resolver
ensp
ENSP00000697723
resolver
ensp
ENSP00000787221
resolver
ensp
ENSP00000787222
resolver
ensp
ENSP00000787223
resolver
enst
ENST00000397977
resolver
genesymbol
INTS10
resolver
genesymbol_syn
C8orf35
resolver
hgnc
HGNC:25548
resolver
uniprot
Q6IA93
resolver
uniprot
Q7L538
resolver
uniprot
Q7L8C8
resolver
uniprot
Q9H3W8
resolver
uniprot_entry
INT10_HUMAN
resolver
uniprot_sec
Q6IA93
resolver
uniprot_sec
Q7L538
resolver
uniprot_sec
Q7L8C8
resolver
uniprot_sec
Q9H3W8
resolver
amino_acid_sequence
MSAQGDCEFLVQRARELVPQDLWAAKAWLITARSLYPADFNIQYEMYTIERNAERTATAGRLLYDMFVNFPDQPVVWREISIITSALRNDSQDKQTQFLRSLFETLPGRVQCEMLLKVTEQCFNTLERSEMLLLLLRRFPETVVQHGVGLGEALLEAETIEEQESPVNCFRKLFVCDVLPLIINNHDVRLPANLLYKYLNKAAEFYINYVTRSTQIENQHQGAQDTSDLMSPSKRSSQKYIIEGLTEKSSQIVDPWERLFKILNVVGMRCEWQMDKGRRSYGDILHRMKDLCRYMNNFDSEAHAKYKNQVVYSTMLVFFKNAFQYVNSIQPSLFQGPNAPSQVPLVLLEDVSNVYGDVEIDRNKHIHKKRKLAEGREKTMSSDDEDCSAKGRNRHIVVNKAELANSTEVLESFKLARESWELLYSLEFLDKEFTRICLAWKTDTWLWLRIFLTDMIIYQGQYKKAIASLHHLAALQGSISQPQITGQGTLEHQRALIQLATCHFALGEYRMTCEKVLDLMCYMVLPIQDGGKSQEEPSKVKPKFRKGSDLKLLPCTSKAIMPYCLHLMLACFKLRAFTDNRDDMALGHVIVLLQQEWPRGENLFLKAVNKICQQGNFQYENFFNYVTNIDMLEEFAYLRTQEGGKIHLELLPNQGMLIKHHTVTRGITKGVKEDFRLAMERQVSRCGENLMVVLHRFCINEKILLLQTLT
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:32647223). Within the integrator complex, INTS10 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:32647223, ECO:0000269|PubMed:38570683, ECO:0000269|PubMed:38823386}.
uniprot
proteins
mass_dalton
82236
uniprot
proteins
mutagenesis
MUTAGEN 28..29; /note="WL->PP: Abolished interaction with INTS15."; /evidence="ECO:0000269|PubMed:36920904"; MUTAGEN 633..634; /note="EE->AA: Abolished interaction with INTS13 and INTS14."; /evidence="ECO:0000269|PubMed:36920904
uniprot
proteins
protein_family
Integrator subunit 10 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16239144
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23904267
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
32647223
uniprot
proteins
pubmed
36920904
uniprot
proteins
pubmed
38570683
uniprot
proteins
pubmed
38823386
uniprot
proteins
pubmed
39032490
uniprot
proteins
sequence_length
710
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:39032490}.
uniprot
proteins