RUNX3
entrez
864
canonical
uniprot
Q13761
canonical
ensembl
ENSG00000020633
resolver
ensp
ENSP00000308051
resolver
ensp
ENSP00000343477
resolver
ensp
ENSP00000382800
resolver
genesymbol
RUNX3
resolver
genesymbol_syn
AML2
resolver
genesymbol_syn
CBFA3
resolver
genesymbol_syn
PEBP2A3
resolver
hgnc
HGNC:10473
resolver
uniprot
B1AJV5
resolver
uniprot
Q12969
resolver
uniprot
Q13760
resolver
uniprot_entry
RUNX3_HUMAN
resolver
uniprot_sec
B1AJV5
resolver
uniprot_sec
Q12969
resolver
uniprot_sec
Q13760
resolver
amino_acid_sequence
MRIPVDPSTSRRFTPPSPAFPCGGGGGKMGENSGALSAQAAVGPGGRARPEVRSMVDVLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREPRRHRQKLEDQTKPFPDRFGDLERLRMRVTPSTPSPRGSLSTTSHFSSQPQTPIQGTSELNPFSDPRQFDRSFPTLPTLTESRFPDPRMHYPGAMSAAFPYSATPSGTSISSLSVAGMPATSRFHHTYLPPPYPGAPQNQSGPFQANPSPYHLYYGTSSGSYQFSMVAGSSSGGDRSPTRMLASCTSSAASVAAGNLMNPSLGGQSDGVEADGSHSNSPTALSTPGRMDEAVWRPY
uniprot
proteins
function
FUNCTION: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity). {ECO:0000250|UniProtKB:Q64131, ECO:0000269|PubMed:20599712}.
uniprot
proteins
mass_dalton
44356
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN. {ECO:0000269|PubMed:20100835}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16652147
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17377532
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
20100835
uniprot
proteins
pubmed
20599712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
7607690
uniprot
proteins
pubmed
7622058
uniprot
proteins
pubmed
7835892
uniprot
proteins
pubmed
9751710
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00399, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20599712}. Cytoplasm {ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20599712}. Note=The tyrosine phosphorylated form localizes to the cytoplasm. Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. {ECO:0000269|PubMed:20599712}.
uniprot
proteins