TRPC3
entrez
7222
canonical
uniprot
Q13507
canonical
ensembl
ENSG00000138741
resolver
ensp
ENSP00000264811
resolver
ensp
ENSP00000368966
resolver
ensp
ENSP00000541594
resolver
ensp
ENSP00000619733
resolver
genesymbol
TRPC3
resolver
genesymbol_syn
TRP3
resolver
hgnc
HGNC:12335
resolver
uniprot
A7VJS1
resolver
uniprot
E9PCJ9
resolver
uniprot
O00593
resolver
uniprot
Q15660
resolver
uniprot
Q52M35
resolver
uniprot
Q5G1L5
resolver
uniprot_entry
TRPC3_HUMAN
resolver
uniprot_sec
A7VJS1
resolver
uniprot_sec
E9PCJ9
resolver
uniprot_sec
O00593
resolver
uniprot_sec
Q15660
resolver
uniprot_sec
Q52M35
resolver
uniprot_sec
Q5G1L5
resolver
activity_regulation
ACTIVITY REGULATION: Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:9930701). Activated by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3 (PubMed:10611319). May be activated by internal calcium store depletion. Inhibited by intracellular Ca(2+) (PubMed:35051376). {ECO:0000269|PubMed:10611319, ECO:0000269|PubMed:35051376, ECO:0000269|PubMed:9930701}.
uniprot
proteins
amino_acid_sequence
MSTKVRKCKEQARVTFPAPEEEEDEGEDEGAEPQRRRRGWRGVNGGLEPRSAPSQREPHGYCPPPFSHGPDLSMEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSMLRCE
uniprot
proteins
disease_involvement
DISEASE: Spinocerebellar ataxia 41 (SCA41) [MIM:616410]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. {ECO:0000269|PubMed:25477146}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:29726814, PubMed:30139744, PubMed:35051376, PubMed:9417057, PubMed:9930701, PubMed:10611319). {ECO:0000269|PubMed:10611319, ECO:0000269|PubMed:29726814, ECO:0000269|PubMed:30139744, ECO:0000269|PubMed:35051376, ECO:0000269|PubMed:9417057, ECO:0000269|PubMed:9930701}.; FUNCTION: [Isoform 2]: Forms a receptor-activated non-selective calcium permeant cation channel. May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G protein-coupled receptors. {ECO:0000269|PubMed:8646775}.
uniprot
proteins
mass_dalton
105538
uniprot
proteins
mutagenesis
MUTAGEN 525; /note="E->A: No effect on inhibition by Ca(2+) or thermostability. No effect on activation by diacylglycerol (DAG) analog; when associated with A-874 and A-883."; /evidence="ECO:0000269|PubMed:35051376"; MUTAGEN 874; /note="E->A: Retains robust Ca(2+) inhibition with moderate enhancement of thermostability in low-Ca(2+) conditions. No effect on activation by diacylglycerol (DAG) analog; when associated with A-525 and A-883."; /evidence="ECO:0000269|PubMed:35051376"; MUTAGEN 883; /note="D->A: Loss of inhibition by intracellular Ca(2+) and loss of Ca(2+)-induced thermostability. Impaired extracellular Ca(2+) inhibition at a holding potential of -60 mV. No effect on activation by diacylglycerol (DAG) analog; when associated with A-525 and A-874."; /evidence="ECO:0000269|PubMed:35051376"; MUTAGEN 888; /note="R->C: Loss of inhibition by intracellular Ca(2+) and loss of Ca(2+)-induced thermostability."; /evidence="ECO:0000269|PubMed:35051376
uniprot
proteins
protein_family
STrpC subfamily
uniprot
proteins
protein_family
TRPC3 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
10611319
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15728370
uniprot
proteins
pubmed
15757897
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17258231
uniprot
proteins
pubmed
17850865
uniprot
proteins
pubmed
20095964
uniprot
proteins
pubmed
25477146
uniprot
proteins
pubmed
29700422
uniprot
proteins
pubmed
29726814
uniprot
proteins
pubmed
30139744
uniprot
proteins
pubmed
35051376
uniprot
proteins
pubmed
7568191
uniprot
proteins
pubmed
8646775
uniprot
proteins
pubmed
9215637
uniprot
proteins
pubmed
9417057
uniprot
proteins
pubmed
9535843
uniprot
proteins
pubmed
9853757
uniprot
proteins
pubmed
9930701
uniprot
proteins
sequence_length
921
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25477146}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 460..477; /note="Helical"; /evidence="ECO:0000269|PubMed:29726814"; TRANSMEM 509..527; /note="Helical"; /evidence="ECO:0000269|PubMed:29726814"; TRANSMEM 541..562; /note="Helical"; /evidence="ECO:0000269|PubMed:29726814"; TRANSMEM 607..630; /note="Helical"; /evidence="ECO:0000269|PubMed:29726814"; TRANSMEM 650..673; /note="Helical"; /evidence="ECO:0000269|PubMed:29726814"; TRANSMEM 714..739; /note="Helical"; /evidence="ECO:0000269|PubMed:29726814
uniprot
proteins