POU4F2
entrez
5458
canonical
uniprot
Q12837
canonical
ensembl
ENSG00000151615
resolver
ensp
ENSP00000281321
resolver
genesymbol
POU4F2
resolver
genesymbol_syn
BRN3B
resolver
hgnc
HGNC:9219
resolver
uniprot
B1PJR6
resolver
uniprot
B2RC84
resolver
uniprot
Q13883
resolver
uniprot
Q14987
resolver
uniprot_entry
PO4F2_HUMAN
resolver
uniprot_sec
B1PJR6
resolver
uniprot_sec
B2RC84
resolver
uniprot_sec
Q13883
resolver
uniprot_sec
Q14987
resolver
amino_acid_sequence
MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI
uniprot
proteins
function
FUNCTION: Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells (PubMed:19266028, PubMed:23805044). Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner (PubMed:19266028, PubMed:23805044). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis. Negatively regulates BAX promoter activity in the absence of TP53. Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif. Involved in TNFSF11-mediated terminal osteoclast differentiation (By similarity). {ECO:0000250|UniProtKB:Q63934, ECO:0000269|PubMed:19266028, ECO:0000269|PubMed:23805044}.
uniprot
proteins
mass_dalton
43087
uniprot
proteins
mutagenesis
MUTAGEN 171..185; /note="Missing: Absent from nuclear speckle; no change in transcriptional activity."; /evidence="ECO:0000269|PubMed:19266028
uniprot
proteins
protein_family
Class-4 subfamily
uniprot
proteins
protein_family
POU transcription factor family
uniprot
proteins
pubmed
11526481
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19266028
uniprot
proteins
pubmed
23805044
uniprot
proteins
pubmed
7691107
uniprot
proteins
pubmed
8234287
uniprot
proteins
pubmed
8332509
uniprot
proteins
sequence_length
409
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7691107}. Nucleus speckle {ECO:0000269|PubMed:19266028}. Cytoplasm {ECO:0000250|UniProtKB:Q63934}.
uniprot
proteins