SCIN
entrez
85477
canonical
uniprot
Q9Y6U3
canonical
ensembl
ENSG00000006747
resolver
ensp
ENSP00000297029
resolver
ensp
ENSP00000430997
resolver
genesymbol
SCIN
resolver
genesymbol_syn
KIAA1905
resolver
hgnc
HGNC:21695
resolver
uniprot
A8K2U8
resolver
uniprot
Q8NBZ6
resolver
uniprot
Q8WU97
resolver
uniprot
Q96JC7
resolver
uniprot
Q96PY2
resolver
uniprot_entry
SCIN_HUMAN
resolver
uniprot_sec
A8K2U8
resolver
uniprot_sec
Q8NBZ6
resolver
uniprot_sec
Q8WU97
resolver
uniprot_sec
Q96JC7
resolver
uniprot_sec
Q96PY2
resolver
amino_acid_sequence
MARELYHEEFARAGKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRGFTYHLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGGLKYKAGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKANQVATGIRYNERKGRSELIVVEEGSEPSELIKVLGEKPELPDGGDDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW
uniprot
proteins
function
FUNCTION: Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:26365202, PubMed:8547642). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009). {ECO:0000250|UniProtKB:Q28046, ECO:0000250|UniProtKB:Q5ZIV9, ECO:0000250|UniProtKB:Q60604, ECO:0000269|PubMed:11568009, ECO:0000269|PubMed:26365202, ECO:0000269|PubMed:8547642}.
uniprot
proteins
mass_dalton
80489
uniprot
proteins
mutagenesis
MUTAGEN 310; /note="M->D: Increases calcium-independent actin-severing activity."; /evidence="ECO:0000269|PubMed:26365202"; MUTAGEN 314; /note="E->S: Increases calcium-independent actin-severing activity."; /evidence="ECO:0000269|PubMed:26365202"; MUTAGEN 455; /note="F->D: Loss of actin-binding."; /evidence="ECO:0000269|PubMed:19666531
uniprot
proteins
protein_family
Villin/gelsolin family
uniprot
proteins
pubmed
11568009
uniprot
proteins
pubmed
11572484
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19666531
uniprot
proteins
pubmed
26365202
uniprot
proteins
pubmed
8547642
uniprot
proteins
sequence_length
715
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, podosome {ECO:0000250|UniProtKB:Q60604}.
uniprot
proteins