Grhl3
entrez
230824
canonical
uniprot
Q5FWH3
canonical
ensembl
ENSMUSG00000037188
resolver
ensp
ENSMUSP00000101481
resolver
ensp
ENSMUSP00000309014
resolver
enst
ENSMUST00000105855
resolver
genesymbol
Grhl3
resolver
genesymbol_syn
Get1
resolver
genesymbol_syn
Som
resolver
genesymbol_syn
Tfcp2l4
resolver
uniprot
A2ADI2
resolver
uniprot_entry
GRHL3_MOUSE
resolver
uniprot_sec
A2ADI2
resolver
amino_acid_sequence
MSNELDFRSVRLLKNDPVSFQKFPYSNEDEAWKTYLENPLTAATKAMMRVNGDEESVAALSFLYDYYMGPKEKRILSSSTGGRNDQGKKFYHSMDYEPDLAPLESPTHLMKFLTENVSGSPDYTDQLKKNNLLGLEGVLPTPGKTNTVPPGPSKLEASSMDSYLLPASDIYDNGSLNSLFESIHGVPPTQRWQPDSTFKDDPQESLLFPDILKTSPDPPCPEDYPGLKSDFEYTLGSPKAIHIKAGESPMAYLNKGQFYPVTLRTPAGGKGLALSSSKVKSVVMVVFDNDKVPVEQLRFWRHWHSRQPTAKQRVIDVADCKENFNTVQHIEEVAYNALSFVWNVNEEAKVFIGVNCLSTDFSSQKGVKGVPLNLQIDTYDCGAGTERLVHRAVCQIKIFCDKGAERKMRDDERKQFRRKVKCPDSSNNAGIKGCLLSGFRGNETTYLRPETDLETQPVLFIPNLHFSSLQRPGGVVPSAGHSSSDRLPLKRTCSPFAEEFEPLPSKQAKEDDLQRVLLYVRRETEEVFDALMLKTPDLKGLRNAISEKYGLPEENICKVYKKCKRGILVNMDNNIIQHYSNHVAFLLDMGELDGKIQIILKEL
uniprot
proteins
function
FUNCTION: Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes. Essential for epidermal differentiation and barrier formation at the end of embryogenesis with TGM3 as critical direct target (PubMed:20654612, PubMed:21081122, PubMed:25347468). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events such as eyelid fusion and epidermal wound repair (PubMed:21081122). Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury (PubMed:25347468). Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (PubMed:14608380, PubMed:20654612). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL1, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122). {ECO:0000269|PubMed:14608380, ECO:0000269|PubMed:16949565, ECO:0000269|PubMed:20654612, ECO:0000269|PubMed:21081122, ECO:0000269|PubMed:24360809, ECO:0000269|PubMed:25347468}.
uniprot
proteins
mass_dalton
67816
uniprot
proteins
protein_family
Grainyhead subfamily
uniprot
proteins
protein_family
Grh/CP2 family
uniprot
proteins
pubmed
14608380
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16949565
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20654612
uniprot
proteins
pubmed
21081122
uniprot
proteins
pubmed
24360809
uniprot
proteins
pubmed
25347468
uniprot
proteins
sequence_length
603
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21081122}.
uniprot
proteins