Cd300a
entrez
217303
canonical
uniprot
Q6SJQ0
canonical
ensembl
ENSMUSG00000034652
resolver
ensp
ENSMUSP00000036773
resolver
ensp
ENSMUSP00000102192
resolver
genesymbol
Cd300a
resolver
genesymbol_syn
Clm8
resolver
genesymbol_syn
Lmir1
resolver
genesymbol_syn
Mcpir1
resolver
uniprot
B9EIB1
resolver
uniprot
Q7TN56
resolver
uniprot
Q7TSN3
resolver
uniprot
Q8CFN3
resolver
uniprot_entry
CLM8_MOUSE
resolver
uniprot_sec
B9EIB1
resolver
uniprot_sec
Q7TN56
resolver
uniprot_sec
Q7TSN3
resolver
uniprot_sec
Q8CFN3
resolver
amino_acid_sequence
MTQLASAVWLPTLLLLLLLFWLPGCVPLHGPSTMSGSVGESLSVSCRYEEKFKTKDKYWCRVSLKILCKDIVKTSSSEEARSGRVTIRDHPDNLTFTVTYESLTLEDADTYMCAVDISLFDGSLGFDKYFKIELSVVPSEDPVSSPGPTLETPVVSTSLPTKGPALGSNTEGHREHDYSQGLRLPALLSVLALLLFLLVGTSLLAWRMFQKRLVKADRHPELSQNLRQASEQNECQYVNLQLHTWSLREEPVLPSQVEVVEYSTLALPQEELHYSSVAFNSQRQDSHANGDSLHQPQDQKAEYSEIQKPRKGLSDLYL
uniprot
proteins
function
FUNCTION: Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:12874256, PubMed:12893283, PubMed:16339535). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity). {ECO:0000250|UniProtKB:Q9UGN4, ECO:0000269|PubMed:12874256, ECO:0000269|PubMed:12893283, ECO:0000269|PubMed:16339535}.
uniprot
proteins
mass_dalton
35629
uniprot
proteins
mutagenesis
MUTAGEN 237; /note="Y->F: Abolishes internalization after cross-linking."; /evidence="ECO:0000269|PubMed:12874256
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine. {ECO:0000269|PubMed:12874256, ECO:0000269|PubMed:12893283}.; PTM: N-glycosylated. {ECO:0000269|PubMed:12874256}.
uniprot
proteins
protein_family
CD300 family
uniprot
proteins
pubmed
12874256
uniprot
proteins
pubmed
12893283
uniprot
proteins
pubmed
14662855
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16339535
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12874256, ECO:0000269|PubMed:12893283}; Single-pass type I membrane protein {ECO:0000269|PubMed:12874256, ECO:0000269|PubMed:12893283}.
uniprot
proteins
transmembrane_region
TRANSMEM 186..206; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins