Slc28a1
entrez
116642
canonical
uniprot
Q62674
canonical
ensembl
ENSRNOG00000018940
resolver
ensembl
ENSRNOG00055008906
resolver
ensembl
ENSRNOG00060003724
resolver
ensembl
ENSRNOG00065031108
resolver
ensp
ENSRNOP00000025621
resolver
ensp
ENSRNOP00055012004
resolver
ensp
ENSRNOP00060004574
resolver
ensp
ENSRNOP00065044072
resolver
enst
ENSRNOT00000025621
resolver
enst
ENSRNOT00055015037
resolver
enst
ENSRNOT00060006165
resolver
enst
ENSRNOT00065053624
resolver
genesymbol
Slc28a1
resolver
genesymbol_syn
Cnt1
resolver
uniprot
F1LNH7
resolver
uniprot_entry
F1LNH7_RAT
resolver
uniprot_entry
S28A1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Due to its high apparent affinity but slow transport, adenosine could act as a negative regulator of pyrimidine transport under some conditions. {ECO:0000250|UniProtKB:O00337}.
uniprot
proteins
amino_acid_sequence
MADNTQRQRESISLTPMAHGLENMGAEFLESMEEGRLPHSHSSLPEGEGGLNKAERKAFSRWRSLQPTVQARSFCREHRQLFGWICKGLLSTACLGFLMVACLLDLQRALALLIITCVVLVFLAYDLLKRLLGSKLRRCVKFQGHSCLSLWLKRGLALAAGVGLILWLSLDTAQRPEQLVSFAGICVFLVLLFAGSKHHRAVSWRAVSWGLGLQFVLGLFVIRTEPGFIAFQWLGDQIQVFLSYTEAGSSFVFGEALVKDVFAFQVLPIIIFFSCVMSVLYYLGLMQWVILKIAWLMQVTMGTSATETLSVAGNIFVSQTEAPLLIRPYLADMTLSEVHVVMTGGYATIAGSLLGAYISFGIDAASLIAASVMAAPCALALSKLVYPEVEESKFRSENGVKLTYGDAQNLLEAASAGAAISVKVVANIAANLIAFLAVLAFVNAALSWLGDMVDIQGLSFQLICSYVLRPVAFLMGVAWEDCPVVAELLGIKFFLNEFVAYQELSQYKQRRLAGAEEWLGDKKQWISVRAEILTTYALCGFANFSSIGIMLGGLTSLVPQRRSDFSQIVLRALITGAFVSLLNACVAGILYVPRGVEVDCVSLLNQTVSSSSFEVYLCCRQVFQSTSSEFSQVALDNCCRFYNHTVCT
uniprot
proteins
function
FUNCTION: Sodium and pyrimidine nucleoside symporter of the plasma membrane that imports uridine, thymidine and cytidine into cells by coupling their transport to the transmembrane sodium electrochemical gradient. Also transports adenosine, an atypical substrate transported with high apparent affinity, but low maximum velocity. Therefore, exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (PubMed:8027026, PubMed:8967974). Involved in renal nucleoside (re)absorption (By similarity). {ECO:0000250|UniProtKB:O00337, ECO:0000269|PubMed:8027026, ECO:0000269|PubMed:8967974}.
uniprot
proteins
mass_dalton
71001
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. N-glycosylation is required for localization to the plasma membrane and the transporter activity. {ECO:0000269|PubMed:11375981}.
uniprot
proteins
protein_family
Concentrative nucleoside transporter (CNT) (TC 2.A.41) family
uniprot
proteins
pubmed
11375981
uniprot
proteins
pubmed
8027026
uniprot
proteins
pubmed
8967974
uniprot
proteins
sequence_length
648
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11375981, ECO:0000269|PubMed:8027026, ECO:0000269|PubMed:8967974}; Multi-pass membrane protein {ECO:0000269|PubMed:11375981}. Apical cell membrane {ECO:0000250|UniProtKB:O00337}; Multi-pass membrane protein {ECO:0000269|PubMed:11375981}.
uniprot
proteins
transmembrane_region
TRANSMEM 81..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..128; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 148..167; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 179..195; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 262..283; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 295..318; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 338..360; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 367..386; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 424..446; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 458..479; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 535..558; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 570..592; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins