Cyp51a1
entrez
13121
canonical
uniprot
Q8K0C4
canonical
ensembl
ENSMUSG00000001467
resolver
ensp
ENSMUSP00000001507
resolver
enst
ENSMUST00000001507
resolver
genesymbol
Cyp51a1
resolver
genesymbol_syn
Cyp51
resolver
uniprot
Q8BSQ7
resolver
uniprot
Q9JIP8
resolver
uniprot
Q9JIY3
resolver
uniprot_entry
CP51A_MOUSE
resolver
uniprot_sec
Q8BSQ7
resolver
uniprot_sec
Q9JIP8
resolver
uniprot_sec
Q9JIY3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by azalanstat. Inhibited by azole antifungal agents ketoconazole, itraconazole and fluconazole. {ECO:0000250|UniProtKB:Q64654}.
uniprot
proteins
amino_acid_sequence
MVLLGLLQSGGWVLGQAMEQVTGGNLLSTLLIACAFTLSLVYLFRLAVGHMVQLPAGAKSPPHIYSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEEVYGRLTTPVFGKGVAYDVPNAIFLEQKKIIKSGLNIAHFKQYVPIIEKEAKEYFQSWGESGERNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFTHAAWLLPAWLPLPSFRRRDRAHREIKNIFYKAIQKRRLSKEPAEDILQTLLDSTYKDGRPLTDEEISGMLIGLLLAGQHTSSTTSAWMGFFLAKDKPLQEKCYLEQKAVCGEDLPPLTYDQLKDLNLLDRCIKETLRLRPPIMTMMRMAKTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWAERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCVGENFAYVQIKTIWSTMLRLYEFDLINGYFPTVNYTTMIHTPENPVIRYKRRSK
uniprot
proteins
ec_number
1.14.14.154
uniprot
proteins
function
FUNCTION: Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis (PubMed:21705796). Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis (PubMed:21705796). Can also demethylate substrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL (By similarity). {ECO:0000250|UniProtKB:Q64654, ECO:0000269|PubMed:21705796}.
uniprot
proteins
mass_dalton
56776
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6. {ECO:0000250|UniProtKB:Q64654}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MARCHF6, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q16850}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10653123
uniprot
proteins
pubmed
10864439
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21705796
uniprot
proteins
sequence_length
503
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q64654}; Single-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:Q64654}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..44; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins