Sppl2b
entrez
73218
canonical
uniprot
Q3TD49
canonical
ensembl
ENSMUSG00000035206
resolver
ensp
ENSMUSP00000036289
resolver
ensp
ENSMUSP00000286729
resolver
ensp
ENSMUSP00000286730
resolver
ensp
ENSMUSP00000286731
resolver
ensp
ENSMUSP00000286733
resolver
ensp
ENSMUSP00000286735
resolver
ensp
ENSMUSP00000286737
resolver
ensp
ENSMUSP00000286741
resolver
ensp
ENSMUSP00000286746
resolver
ensp
ENSMUSP00000286760
resolver
ensp
ENSMUSP00000332294
resolver
ensp
ENSMUSP00000332296
resolver
genesymbol
Sppl2b
resolver
uniprot
Q3TLQ8
resolver
uniprot
Q3UG60
resolver
uniprot
Q80VZ6
resolver
uniprot_entry
SPP2B_MOUSE
resolver
uniprot_sec
Q3TLQ8
resolver
uniprot_sec
Q3UG60
resolver
uniprot_sec
Q80VZ6
resolver
amino_acid_sequence
MAAARLAAALLLLAAQVACEFGVLRVVSQTSRTRSRDYCILYNPQWAHLPHDLSKVSLLKLRDLSTTQLCSYLDVPAEDFTNQIALVARGNCTFYEKVRLAQGSGAHGLLIVSKEKLVPPGGNKTQYEEISIPVALLSHRDLQDIFRRFGREVMVALYAPSEPVMDYNMVIIFVMAVGTVAIGGYWAGSHDVKKYMKHKRDDGPEKQEDEAVDVTPVMICVFVVMCCFMLVLLYYFYDRLVYVIIGIFCLASSTGLYSCLAPFVRKLPFCTCRVPDNNLPYFHKRPQARMLLLALFCVTVSVVWGIFRNEDQWAWVLQDTLGIAFCLYMLKTIRLPTFKACTLLLLVLFIYDIFFVFITPFLTKSGNSIMVEVATGPSNSSTHEKLPMVLKVPRLNTSPLSLCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRIYFVACTIAYGLGLLVTFVALVLMQRGQPALLYLVPCTLLTSCTVALWRRELGAFWTGSGFAKDAPQTPWAATQGPVPPKAVGSSLSEQPPSEELAKSPLSTEEAGAADPAKDPDNPVASPLSPSNGDEAQPIPVVKPETSA
uniprot
proteins
ec_number
3.4.23.-
uniprot
proteins
function
FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity. {ECO:0000250|UniProtKB:Q8TCT7}.
uniprot
proteins
mass_dalton
63824
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q8TCT7}.
uniprot
proteins
protein_family
Peptidase A22B family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21896273
uniprot
proteins
sequence_length
578
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21896273}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8TCT7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TCT7}. Lysosome membrane {ECO:0000250|UniProtKB:Q8TCT7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TCT7}. Endosome membrane {ECO:0000250|UniProtKB:Q8TCT7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TCT7}. Membrane {ECO:0000250|UniProtKB:Q8TCT7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TCT7}; Lumenal side {ECO:0000250|UniProtKB:Q8TCT7}. Note=targeted through the entire secretory pathway to endosomes/lysosomes. {ECO:0000250|UniProtKB:Q8TCT7}.
uniprot
proteins
transmembrane_region
TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 240..260; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 287..307; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 313..333; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 342..362; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 406..426; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 439..459; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 464..484; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins