Pi4k2a
entrez
84095
canonical
uniprot
Q2TBE6
canonical
ensembl
ENSMUSG00000025178
resolver
ensp
ENSMUSP00000069284
resolver
ensp
ENSMUSP00000158574
resolver
ensp
ENSMUSP00000183627
resolver
ensp
ENSMUSP00000183628
resolver
enst
ENSMUST00000066778
resolver
enst
ENSMUST00000235932
resolver
genesymbol
Pi4k2a
resolver
uniprot_entry
P4K2A_MOUSE
resolver
amino_acid_sequence
MDETSPLVSPERAQPPEYTFPSGSGAHFPQVPGGAVRVAAAAGSGPSPPCSPGHDRERQPLLDRARGAAAQGQTHTVAVQAQALAAQAAVAAHAVQTHRERNDFPEDPEFEVVVRQAEVAIECSIYPERIYQGSSGSYFVKDSQGRIVAVFKPKNEEPYGHLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIKYDCPMDNSSCRDTDWVMVREPVIKVAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFIKDLEEDLYELFKRDPGFDRGQFHKQIAVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSHQRSASESYTQSFQSRKPFFSWW
uniprot
proteins
ec_number
2.7.1.67
uniprot
proteins
function
FUNCTION: Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). {ECO:0000269|PubMed:19581584, ECO:0000305}.
uniprot
proteins
mass_dalton
54258
uniprot
proteins
post_translational_modification
PTM: Palmitoylated by ZDHHC3 and ZDHHC7 in the CCPCC motif. Palmitoylation is cholesterol-dependent, and required for TGN localization (By similarity). {ECO:0000250|UniProtKB:Q9BTU6}.; PTM: Ubiquitinated by ITCH; this does not lead to proteasomal degradation. {ECO:0000269|PubMed:23146885}.
uniprot
proteins
protein_family
PI3/PI4-kinase family
uniprot
proteins
protein_family
Type II PI4K subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19581584
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21998198
uniprot
proteins
pubmed
22105363
uniprot
proteins
pubmed
23146885
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9BTU6}; Lipid-anchor {ECO:0000250|UniProtKB:Q9BTU6}. Membrane raft {ECO:0000250|UniProtKB:Q9BTU6}. Endosome {ECO:0000250|UniProtKB:Q99M64}. Endosome membrane {ECO:0000250|UniProtKB:Q9BTU6}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q99M64}. Cell projection, dendrite {ECO:0000269|PubMed:21998198}. Presynaptic cell membrane {ECO:0000269|PubMed:21998198}. Synapse, synaptosome {ECO:0000269|PubMed:21998198}. Mitochondrion {ECO:0000269|PubMed:21998198}. Membrane {ECO:0000269|PubMed:19581584}; Lipid-anchor {ECO:0000250|UniProtKB:Q9BTU6}. Cell membrane {ECO:0000250|UniProtKB:Q9BTU6}. Perikaryon {ECO:0000269|PubMed:21998198}. Cell projection, neuron projection {ECO:0000269|PubMed:21998198}. Note=Found in subdomains of the plasma membrane termed non-caveolar membrane rafts. Transported from neuronal cell body to neuron projections and neurite tips in a BLOC-1- and AP-3-complexes-dependent manner (PubMed:21998198). {ECO:0000269|PubMed:21998198}.
uniprot
proteins