Fzd1
entrez
14362
canonical
uniprot
O70421
canonical
ensembl
ENSMUSG00000044674
resolver
ensp
ENSMUSP00000058629
resolver
enst
ENSMUST00000054294
resolver
genesymbol
Fzd1
resolver
uniprot
O08974
resolver
uniprot
Q7TS82
resolver
uniprot_entry
FZD1_MOUSE
resolver
uniprot_sec
O08974
resolver
uniprot_sec
Q7TS82
resolver
amino_acid_sequence
MAEEAAPSESRAAGRLSLELCAEALPGRREEVGHEDTASHRRPRADPRRWASGLLLLLWLLEAPLLLGVRAQAAGQVSGPGQQAPPPPQPQQSGQQYNGERGISIPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGYRGGYPGGAGTVERGKFSCPRALRVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins (PubMed:15923619). Activated by WNT7B (PubMed:15923619). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (By similarity). Contradictory results showing activation by WNT7B have been described for mouse (PubMed:15923619). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:15923619). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). {ECO:0000250|UniProtKB:Q9UP38, ECO:0000269|PubMed:15923619, ECO:0000305}.
uniprot
proteins
mass_dalton
71127
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
11334716
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15923619
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
642
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15923619}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 318..338; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 350..370; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 398..418; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 441..461; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 485..505; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 532..552; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 594..614; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins