PIR
entrez
8544
canonical
uniprot
O00625
canonical
ensembl
ENSG00000087842
resolver
ensp
ENSP00000369785
resolver
ensp
ENSP00000369786
resolver
ensp
ENSP00000579280
resolver
ensp
ENSP00000579282
resolver
ensp
ENSP00000579287
resolver
ensp
ENSP00000579288
resolver
ensp
ENSP00000602828
resolver
ensp
ENSP00000602830
resolver
ensp
ENSP00000616632
resolver
ensp
ENSP00000616633
resolver
ensp
ENSP00000616634
resolver
ensp
ENSP00000616635
resolver
enst
ENST00000380420
resolver
enst
ENST00000380421
resolver
enst
ENST00000909221
resolver
enst
ENST00000909223
resolver
enst
ENST00000909228
resolver
enst
ENST00000909229
resolver
enst
ENST00000932769
resolver
enst
ENST00000932771
resolver
enst
ENST00000946573
resolver
enst
ENST00000946574
resolver
enst
ENST00000946575
resolver
enst
ENST00000946576
resolver
genesymbol
PIR
resolver
hgnc
HGNC:30048
resolver
uniprot
Q5U0G0
resolver
uniprot
Q6FHD2
resolver
uniprot_entry
PIR_HUMAN
resolver
uniprot_sec
Q5U0G0
resolver
uniprot_sec
Q6FHD2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by kojic acid, sodium diethyldithiocarbamate and 1,10-phenanthroline monohydrochloride. {ECO:0000269|PubMed:15951572}.
uniprot
proteins
amino_acid_sequence
MGSSKKVTLSVLSREQSEGVGARVRRSIGRPELKNLDPFLLFDEFKGGRPGGFPDHPHRGFETVSYLLEGGSMAHEDFCGHTGKMNPGDLQWMTAGRGILHAEMPCSEEPAHGLQLWVNLRSSEKMVEPQYQELKSEEIPKPSKDGVTVAVISGEALGIKSKVYTRTPTLYLDFKLDPGAKHSQPIPKGWTSFIYTISGDVYIGPDDAQQKIEPHHTAVLGEGDSVQVENKDPKRSHFVLIAGEPLREPVIQHGPFVMNTNEEISQAILDFRNAKNGFERAKTWKSKIGN
uniprot
proteins
ec_number
1.13.11.24
uniprot
proteins
function
FUNCTION: Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). {ECO:0000269|PubMed:15951572, ECO:0000269|PubMed:17288615, ECO:0000269|PubMed:20010624, ECO:0000269|PubMed:20711196, ECO:0000269|PubMed:23716661}.
uniprot
proteins
mass_dalton
32113
uniprot
proteins
pathway_participation
PATHWAY: Flavonoid metabolism; quercetin degradation. {ECO:0000305|PubMed:15951572}.
uniprot
proteins
protein_family
Pirin family
uniprot
proteins
pubmed
10362352
uniprot
proteins
pubmed
14573596
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15951572
uniprot
proteins
pubmed
17288615
uniprot
proteins
pubmed
19766747
uniprot
proteins
pubmed
20010624
uniprot
proteins
pubmed
20089166
uniprot
proteins
pubmed
20711196
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23716661
uniprot
proteins
pubmed
9079676
uniprot
proteins
sequence_length
290
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20089166, ECO:0000269|PubMed:9079676}. Cytoplasm {ECO:0000269|PubMed:20089166}. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression. {ECO:0000269|PubMed:20089166, ECO:0000269|PubMed:9079676}.
uniprot
proteins