Acat1
entrez
110446
canonical
uniprot
Q8QZT1
canonical
ensembl
ENSMUSG00000032047
resolver
ensp
ENSMUSP00000034547
resolver
enst
ENSMUST00000034547
resolver
genesymbol
Acat1
resolver
uniprot
Q3TE92
resolver
uniprot_entry
THIL_MOUSE
resolver
uniprot_sec
Q3TE92
resolver
activity_regulation
ACTIVITY REGULATION: Activated by potassium ions, but not sodium ions. {ECO:0000250|UniProtKB:P24752}.
uniprot
proteins
amino_acid_sequence
MAALVALHGVVRRPLLRGLLQEVRCLERSYASKPTLNEVVIVSAIRTPIGSFLGSLASQPATKLGTAAIQGAIEKAGIPKEEVKEVYMGNVIQGGEGQAPTRQATLGAGLPISTPCTTVNKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMSRGATPYGGVKLEDLIVKDGLTDVYNKIHMGNCAENTAKKMNISRQEQDTYALSSYTRSKEAWDAGKFASEITPITISVKGKPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTITAANASTLNDGAAALVLMTAEAAQRLNVKPLARIAAFADAAVDPIDFPLAPAYAVPKVLKYAGLKKEDIAMWEVNEAFSVVVLANIKMLEIDPQKVNIHGGAVSLGHPIGMSGARIVVHMAHALKPGEFGLASICNGGGGASALLIEKL
uniprot
proteins
ec_number
2.3.1.9
uniprot
proteins
function
FUNCTION: This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. {ECO:0000250|UniProtKB:P24752}.
uniprot
proteins
mass_dalton
44816
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000250|UniProtKB:P24752}.
uniprot
proteins
post_translational_modification
PTM: Succinylation at Lys-265, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5.
uniprot
proteins
protein_family
Thiolase family
uniprot
proteins
protein_family
Thiolase-like superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P24752}.
uniprot
proteins