Cby1
entrez
246768
canonical
uniprot
Q8K4I6
canonical
genesymbol
Cby1
resolver
genesymbol_syn
Cby
resolver
genesymbol_syn
Pgea1
resolver
uniprot_entry
CBY1_RAT
resolver
amino_acid_sequence
MPLFGSIFSPKKTPPRKSASLSNLHSLDRSTRELELGLDYGTPTMNLAGQSLKFENGQWVADSVISGGVDRRETQRLRKRNQQLEEENNLLRLKVDILLDMLSETTAESHLKDKELDELKITNRRRK
uniprot
proteins
function
FUNCTION: Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. {ECO:0000250|UniProtKB:Q9D1C2, ECO:0000250|UniProtKB:Q9Y3M2}.
uniprot
proteins
mass_dalton
14549
uniprot
proteins
protein_family
Chibby family
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
127
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q9Y3M2}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9Y3M2}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9Y3M2}. Golgi apparatus {ECO:0000250|UniProtKB:Q9Y3M2}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9Y3M2}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9D1C2}. Nucleus {ECO:0000250|UniProtKB:Q9Y3M2}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y3M2}. Note=Nuclear, in a punctate manner (By similarity). {ECO:0000250|UniProtKB:Q9Y3M2}.
uniprot
proteins