Taldo1
entrez
21351
canonical
uniprot
Q93092
canonical
ensembl
ENSMUSG00000025503
resolver
ensp
ENSMUSP00000026576
resolver
genesymbol
Taldo1
resolver
genesymbol_syn
Tal
resolver
genesymbol_syn
Taldo
resolver
uniprot
P70358
resolver
uniprot
P70703
resolver
uniprot
Q52KM4
resolver
uniprot_entry
TALDO_MOUSE
resolver
uniprot_sec
P70358
resolver
uniprot_sec
P70703
resolver
uniprot_sec
Q52KM4
resolver
amino_acid_sequence
MSGSPVKRQRMESALDQLKQFTTVVADTGDFNAIDEYKPQDATTNPSLILAAAQMPAYQELVEEAIAYGKKLGGPQEEQIKNAIDKLFVLFGAEILKKIPGRVSTEVDARLSFDKDAMVARARRLIELYKEAGVGKDRILIKLSSTWEGIQAGKELEEQHGIHCNMTLLFSFAQAVACAEAGVTLISPFVGRILDWHVANTDKKSYEPQEDPGVKSVTKIYNYYKKFGYKTIVMGASFRNTGEIKALAGCDFLTISPKLLGELLKDNSKLAPALSVKAAQTSDSEKIHLDEKAFRWLHNEDQMAVEKLSDGIRKFAADAIKLERMLTERMFSAENGK
uniprot
proteins
ec_number
2.2.1.2
uniprot
proteins
function
FUNCTION: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedoheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate (PubMed:17003133, PubMed:27703206). Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm (PubMed:27703206). {ECO:0000269|PubMed:17003133, ECO:0000269|PubMed:27703206}.
uniprot
proteins
mass_dalton
37387
uniprot
proteins
mutagenesis
MUTAGEN 1; /note="M->A: Leads to expression of isoform 2 only."; /evidence="ECO:0000269|PubMed:27703206"; MUTAGEN 7; /note="K->A: Mainly expressed in the cytoplasm; when associated with A-8 and A-10."; /evidence="ECO:0000269|PubMed:27703206"; MUTAGEN 8; /note="R->A: Mainly expressed in the cytoplasm; when associated with A-7 and A-10."; /evidence="ECO:0000269|PubMed:27703206"; MUTAGEN 10; /note="R->A: Mainly expressed in the cytoplasm; when associated with A-7 and A-8."; /evidence="ECO:0000269|PubMed:27703206"; MUTAGEN 11; /note="M->A: Leads to expression of isoform 1 only."; /evidence="ECO:0000269|PubMed:27703206
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. {ECO:0000269|PubMed:19436114}.
uniprot
proteins
protein_family
Transaldolase family
uniprot
proteins
protein_family
Type 1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17003133
uniprot
proteins
pubmed
19436114
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
27703206
uniprot
proteins
pubmed
9524206
uniprot
proteins
sequence_length
337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:27703206}. Cytoplasm {ECO:0000269|PubMed:27703206}. Note=Shuttles between the nucleus and the cytoplasm. Actively transported into the nucleus in an importin alpha/beta-dependent manner (PubMed:27703206). Exported into the cytoplasm by CRM1 (PubMed:27703206). {ECO:0000269|PubMed:27703206}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:27703206}. Note=Imported into the nucleus when incorporated in isoform 1/isoform 2 homodimer. {ECO:0000269|PubMed:27703206}.
uniprot
proteins