Fth1
entrez
14319
canonical
uniprot
P09528
canonical
ensembl
ENSMUSG00000024661
resolver
ensp
ENSMUSP00000025563
resolver
ensp
ENSMUSP00000158539
resolver
enst
ENSMUST00000025563
resolver
enst
ENSMUST00000235196
resolver
genesymbol
Fth1
resolver
genesymbol_syn
Fth
resolver
uniprot
Q3UI44
resolver
uniprot_entry
FRIH_MOUSE
resolver
uniprot_sec
Q3UI44
resolver
amino_acid_sequence
MTTASPSQVRQNYHQDAEAAINRQINLELYASYVYLSMSCYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDRDDWESGLNAMECALHLEKSVNQSLLELHKLATDKNDPHLCDFIETYYLSEQVKSIKELGDHVTNLRKMGAPEAGMAEYLFDKHTLGHGDES
uniprot
proteins
ec_number
1.16.3.1
uniprot
proteins
function
FUNCTION: Stores iron in a soluble, non-toxic, readily available form (By similarity). Important for iron homeostasis (By similarity). Has ferroxidase activity (By similarity). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Also plays a role in delivery of iron to cells (PubMed:19154717). Mediates iron uptake in capsule cells of the developing kidney (PubMed:19154717). Degraded to release iron upon autophagy activation by nutrient starvation (PubMed:25327288). {ECO:0000250|UniProtKB:P02794, ECO:0000269|PubMed:19154717, ECO:0000269|PubMed:25327288}.
uniprot
proteins
mass_dalton
21067
uniprot
proteins
protein_family
Ferritin family
uniprot
proteins
pubmed
10652280
uniprot
proteins
pubmed
11468145
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19154717
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2258056
uniprot
proteins
pubmed
25327288
uniprot
proteins
pubmed
2708374
uniprot
proteins
pubmed
2798146
uniprot
proteins
pubmed
30102720
uniprot
proteins
pubmed
3194211
uniprot
proteins
pubmed
32647824
uniprot
proteins
pubmed
33984504
uniprot
proteins
pubmed
3410854
uniprot
proteins
pubmed
35233453
uniprot
proteins
pubmed
36578473
uniprot
proteins
pubmed
37258702
uniprot
proteins
pubmed
39277607
uniprot
proteins
sequence_length
182
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25327288}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:25327288}. Autolysosome {ECO:0000269|PubMed:25327288}.
uniprot
proteins