Npm1
entrez
25498
canonical
uniprot
P13084
canonical
ensembl
ENSRNOG00000004616
resolver
ensp
ENSRNOP00000006591
resolver
genesymbol
Npm1
resolver
uniprot
Q63698
resolver
uniprot
Q64269
resolver
uniprot_entry
NPM_RAT
resolver
uniprot_sec
Q63698
resolver
uniprot_sec
Q64269
resolver
amino_acid_sequence
MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEDEEDVKLLGMSGKRSAPGGGNKVPQKKVKLDEDDDEDDEDDEDDEDDDDDDFDEEETEEKVPVKKSVRDTPAKNAQKSNQNGKDLKPSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
uniprot
proteins
function
FUNCTION: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes (By similarity). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250|UniProtKB:P06748, ECO:0000250|UniProtKB:Q61937}.
uniprot
proteins
mass_dalton
32560
uniprot
proteins
post_translational_modification
PTM: Acetylated at C-terminal lysine residues, thereby increasing affinity to histones. {ECO:0000250|UniProtKB:P06748}.; PTM: ADP-ribosylated. {ECO:0000250|UniProtKB:P06748}.; PTM: Phosphorylated at Ser-4 by PLK1 and PLK2. Phosphorylation at Ser-4 by PLK2 in S phase is required for centriole duplication and is sufficient to trigger centriole replication. Phosphorylation at Ser-4 by PLK1 takes place during mitosis. Phosphorylated by CDK2 at Ser-125 and Thr-198. Phosphorylation at Thr-198 may trigger initiation of centrosome duplication. Phosphorylated by CDK1 at Thr-198, Thr-217, Thr-232 and Thr-235 during cell mitosis. When these four sites are phosphorylated, RNA-binding activity seem to be abolished. May be phosphorylated at Ser-70 by NEK2. The Thr-198 phosphorylated form has higher affinity for ROCK2 (By similarity). {ECO:0000250|UniProtKB:P06748}.; PTM: Sumoylated by ARF. {ECO:0000250|UniProtKB:P06748}.; PTM: The N-terminus is blocked. {ECO:0000250|UniProtKB:P06748}.; PTM: May be ubiquitinated. Ubiquitination leads to proteasomal degradation. Deubiquitinated by USP36 (By similarity). {ECO:0000250|UniProtKB:P06748}.
uniprot
proteins
protein_family
Nucleoplasmin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20075868
uniprot
proteins
pubmed
2211699
uniprot
proteins
pubmed
2745414
uniprot
proteins
pubmed
3417636
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P06748}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P06748}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P06748}. Note=Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML. Co-localizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. Isoform 1 of NEK2 is required for its localization to the centrosome during mitosis. Can shuttle between cytoplasm and nucleus. {ECO:0000250|UniProtKB:P06748}.
uniprot
proteins