Alkbh3
entrez
69113
canonical
uniprot
Q8K1E6
canonical
ensembl
ENSMUSG00000040174
resolver
ensp
ENSMUSP00000038721
resolver
ensp
ENSMUSP00000265178
resolver
ensp
ENSMUSP00000265181
resolver
ensp
ENSMUSP00000265185
resolver
ensp
ENSMUSP00000265186
resolver
ensp
ENSMUSP00000265187
resolver
ensp
ENSMUSP00000265189
resolver
ensp
ENSMUSP00000265190
resolver
ensp
ENSMUSP00000265192
resolver
ensp
ENSMUSP00000265195
resolver
ensp
ENSMUSP00000265217
resolver
ensp
ENSMUSP00000265223
resolver
ensp
ENSMUSP00000265229
resolver
ensp
ENSMUSP00000351892
resolver
enst
ENSMUST00000040005
resolver
genesymbol
Alkbh3
resolver
genesymbol_syn
Abh3
resolver
uniprot_entry
ALKB3_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by ascorbate. {ECO:0000250|UniProtKB:Q96Q83}.
uniprot
proteins
amino_acid_sequence
MEDKRQRARVQGGWATPTKSQSATQPASPARSRLSQTAGPAWRSKEQQQCDRQFVFKEPQLVVRAAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDLKEADWILEQLCKDVPWKQRMGIREDVTYPQPRLTAWYGELPYTYSRITMEPNPHWLPVLWTLKSRIEENTSHTFNSLLCNFYRDEKDSVDWHSDDEPSLGSCPVIASLSFGATRTFEMRKKPPPEENGDYTYVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSRQPRVNLTFRTVYPDPRGAPR
uniprot
proteins
ec_number
1.14.11.33
uniprot
proteins
ec_number
1.14.11.54
uniprot
proteins
function
FUNCTION: Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) (By similarity). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation (PubMed:16174769). Has a strong preference for single-stranded DNA (PubMed:16174769). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Can repair exocyclic 3,N4-ethenocytosine adducs in single-stranded DNA. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). {ECO:0000250|UniProtKB:Q96Q83, ECO:0000269|PubMed:16174769}.
uniprot
proteins
mass_dalton
33061
uniprot
proteins
mutagenesis
MUTAGEN 193; /note="D->A: Loss of activity."; /evidence="ECO:0000269|PubMed:16174769"; MUTAGEN 257; /note="H->A: Reduced activity."; /evidence="ECO:0000269|PubMed:16174769
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination. OTUD4 promotes USP7 and USP9X-dependent deubiquitination of 'Lys-48'-polyubiquitinated ALKBH3 promoting the repair of alkylated DNA lesions. {ECO:0000250|UniProtKB:Q96Q83}.
uniprot
proteins
protein_family
AlkB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16174769
uniprot
proteins
pubmed
16642038
uniprot
proteins
pubmed
18519673
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
286
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96Q83}. Cytoplasm {ECO:0000250|UniProtKB:Q96Q83}. Note=Colocalizes with ASCC2 and ASCC3 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. Predominantly localizes to the nucleus. {ECO:0000250|UniProtKB:Q96Q83}.
uniprot
proteins