Pik3c3
entrez
225326
canonical
uniprot
Q6PF93
canonical
ensembl
ENSMUSG00000033628
resolver
ensp
ENSMUSP00000111479
resolver
genesymbol
Pik3c3
resolver
genesymbol_syn
Vps34
resolver
uniprot
Q8R3S8
resolver
uniprot_entry
PK3C3_MOUSE
resolver
uniprot_sec
Q8R3S8
resolver
amino_acid_sequence
MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGSAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTRTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNATTRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQTSASESLSNSGVSSGDIDSSQIITNPLPPVASPPPASKAKEVSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSETGPYGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
uniprot
proteins
ec_number
2.7.1.137
uniprot
proteins
function
FUNCTION: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity). {ECO:0000250|UniProtKB:O88763, ECO:0000250|UniProtKB:Q8NEB9}.
uniprot
proteins
mass_dalton
101487
uniprot
proteins
mutagenesis
MUTAGEN 163; /note="T->A: Loss of phosphorylation but no loss of autophagic function; when associated with A-165."; /evidence="ECO:0000269|PubMed:23332761"; MUTAGEN 165; /note="S->A: Loss of phosphorylation but no loss of autophagic function; when associated with A-163."; /evidence="ECO:0000269|PubMed:23332761
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated via 'Lys-29'- and 'Lys-48'-linked ubiquitination by UBE3C, promoting its degradation. Deubiquitination by ZRANB1/TRABID promotes its stabilization, leading to autophagosome maturation. {ECO:0000250|UniProtKB:Q8NEB9}.
uniprot
proteins
protein_family
PI3/PI4-kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17589504
uniprot
proteins
pubmed
21059846
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22493499
uniprot
proteins
pubmed
23332761
uniprot
proteins
pubmed
24089209
uniprot
proteins
pubmed
34428398
uniprot
proteins
sequence_length
887
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Midbody {ECO:0000250|UniProtKB:Q8NEB9}. Late endosome {ECO:0000250|UniProtKB:Q8NEB9}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:22493499}. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (By similarity). Also localizes to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (PubMed:24089209). {ECO:0000250|UniProtKB:Q8NEB9, ECO:0000269|PubMed:24089209}.
uniprot
proteins