Nudt18
entrez
213484
canonical
uniprot
Q3U2V3
canonical
ensembl
ENSMUSG00000045211
resolver
ensp
ENSMUSP00000086450
resolver
ensp
ENSMUSP00000154258
resolver
enst
ENSMUST00000228768
resolver
genesymbol
Nudt18
resolver
uniprot
A0A2I3BQN8
resolver
uniprot
Q8C223
resolver
uniprot
Q8K1Y7
resolver
uniprot_entry
A0A2I3BQN8_MOUSE
resolver
uniprot_entry
NUD18_MOUSE
resolver
uniprot_sec
Q8C223
resolver
uniprot_sec
Q8K1Y7
resolver
amino_acid_sequence
MATEGLAGALATVLGGKGLLVQSCDSEPAGKPLFPVRLRKNVCYVVLAVFLNEQDEVLMIQEAKRECRGTWYLPAGRMEPGETIVEAMQREVKEEAGLLCEPVTLLSVEERGASWIRFVFLARPTGGVLKTSKDADSESLQAGWYPRVSLPTPLRAHDVLHLVELGAKFCQQAMHPLILPQELPCSVVCQRLVTTFTTVQSVWVLVGTVGTPHLPITACGFTPMEQRGGIKVAILRLLQECLTLHSLAVETKGLLGLQHLGRDHVDGVCLNVLVTVAFRNPGIQDEPPKIRGENYFWWKVLEEDLQKLLLYRLQESSVIPLSR
uniprot
proteins
ec_number
3.6.1.58
uniprot
proteins
ec_number
3.6.1.68
uniprot
proteins
ec_number
3.6.1.76
uniprot
proteins
function
FUNCTION: Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Also hydrolyzes 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. In vitro, it catalyzes the hydrolysis of isoprene pyrophosphates, including (2E)-geranyl diphosphate, isopentenyl diphosphate, (2E,6E)-farnesyl diphosphate and dimethylallyl diphosphate. It may therefore play a role in the control of cellular levels of these metabolites that are essential for multiple cellular processes, including isoprenoids synthesis and protein isoprenylation. {ECO:0000250|UniProtKB:Q6ZVK8}.
uniprot
proteins
mass_dalton
35694
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
323
uniprot
proteins