Cyp2c11
entrez
29277
canonical
uniprot
P08683
canonical
ensembl
ENSRNOG00000052810
resolver
ensembl
ENSRNOG00055028578
resolver
ensembl
ENSRNOG00060019291
resolver
ensembl
ENSRNOG00065028890
resolver
ensp
ENSRNOP00000074503
resolver
ensp
ENSRNOP00000098982
resolver
ensp
ENSRNOP00000101757
resolver
ensp
ENSRNOP00055040715
resolver
ensp
ENSRNOP00060027327
resolver
ensp
ENSRNOP00065040971
resolver
enst
ENSRNOT00000088853
resolver
enst
ENSRNOT00000132305
resolver
enst
ENSRNOT00000140439
resolver
enst
ENSRNOT00055049473
resolver
enst
ENSRNOT00060033397
resolver
enst
ENSRNOT00065049889
resolver
genesymbol
Cyp2c11
resolver
genesymbol_syn
Cyp2c
resolver
genesymbol_syn
Cyp2c-11
resolver
uniprot
A0A0G2K879
resolver
uniprot
A0ABK0L0S2
resolver
uniprot
Q63141
resolver
uniprot
Q64554
resolver
uniprot_entry
A0A0G2K879_RAT
resolver
uniprot_entry
A0ABK0L0S2_RAT
resolver
uniprot_entry
CP2CB_RAT
resolver
uniprot_sec
Q63141
resolver
uniprot_sec
Q64554
resolver
amino_acid_sequence
MDPVLVLVLTLSSLLLLSLWRQSFGRGKLPPGPTPLPIIGNTLQIYMKDIGQSIKKFSKVYGPIFTLYLGMKPFVVLHGYEAVKEALVDLGEEFSGRGSFPVSERVNKGLGVIFSNGMQWKEIRRFSIMTLRTFGMGKRTIEDRIQEEAQCLVEELRKSKGAPFDPTFILGCAPCNVICSIIFQNRFDYKDPTFLNLMHRFNENFRLFSSPWLQVCNTFPAIIDYFPGSHNQVLKNFFYIKNYVLEKVKEHQESLDKDNPRDFIDCFLNKMEQEKHNPQSEFTLESLVATVTDMFGAGTETTSTTLRYGLLLLLKHVDVTAKVQEEIERVIGRNRSPCMKDRSQMPYTDAVVHEIQRYIDLVPTNLPHLVTRDIKFRNYFIPKGTNVIVSLSSILHDDKEFPNPEKFDPGHFLDERGNFKKSDYFMPFSAGKRICAGEALARTELFLFFTTILQNFNLKSLVDVKDIDTTPAISGFGHLPPFYEACFIPVQRADSLSSHL
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and fatty acids. Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes testosterone to 2alpha- and 16alpha-hydroxytestosterone (PubMed:2434473). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFAs) (PubMed:10491410, PubMed:15766564). Converts arachidonic acid (ARA, C20:4(n-6)) primarily to epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, with both R,S and S,R stereochemistry (PubMed:10491410). Preferentially produces 11R,12S-EET enantiomer. To a lesser extent, catalyzes the hydroxylation of arachidonic acid producing hydroxyeicosatetraenoates (HETEs) (PubMed:10491410). Metabolizes eicosapentaenoic acid (EPA, C20:5(n-3)) to epoxyeicosatetraenoic acid (EETeTr) regioisomers, 8,9-, 11,12-, 14,15-, and 17,18-EETeTr, preferentially producing 17R,18S-EETeTr enantiomer (PubMed:15766564). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:15766564, PubMed:2434473). {ECO:0000269|PubMed:10491410, ECO:0000269|PubMed:15766564, ECO:0000269|PubMed:2434473}.
uniprot
proteins
mass_dalton
57181
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; arachidonate metabolism. {ECO:0000305|PubMed:10491410}.; PATHWAY: Steroid metabolism. {ECO:0000305|PubMed:2434473}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10491410
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15766564
uniprot
proteins
pubmed
2434473
uniprot
proteins
pubmed
2455430
uniprot
proteins
pubmed
2894840
uniprot
proteins
pubmed
3164963
uniprot
proteins
pubmed
3805049
uniprot
proteins
pubmed
8068205
uniprot
proteins
pubmed
8611037
uniprot
proteins
sequence_length
500
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:2434473}; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:2434473}; Peripheral membrane protein.
uniprot
proteins