Osm
entrez
289747
canonical
uniprot
Q65Z15
canonical
ensembl
ENSRNOG00000024390
resolver
ensembl
ENSRNOG00055030023
resolver
ensembl
ENSRNOG00060027122
resolver
ensembl
ENSRNOG00065029899
resolver
ensp
ENSRNOP00000110195
resolver
ensp
ENSRNOP00000111271
resolver
ensp
ENSRNOP00055042989
resolver
ensp
ENSRNOP00060039128
resolver
ensp
ENSRNOP00065042522
resolver
enst
ENSRNOT00000139324
resolver
enst
ENSRNOT00000142525
resolver
enst
ENSRNOT00055052053
resolver
enst
ENSRNOT00060047045
resolver
enst
ENSRNOT00065051649
resolver
genesymbol
Osm
resolver
uniprot
A0ABK0M768
resolver
uniprot_entry
A0ABK0M768_RAT
resolver
uniprot_entry
ONCM_RAT
resolver
amino_acid_sequence
MRAQPPPRTLLSLALALLFLSMSWAKRGCSSSSPKLLSQLKSQANITGNTASLLEPYILHQNLNTLTLRAACTEHPVAFPSEDMLRQLSKPDFLSTVHATLGRVWHQLGAFRQQFPKIQDFPELERARQNIQGIRNNVYCMARLLHPPLEIPEPTQADSGTSRPTTTAPGIFQIKIDSCRFLWGYHRFMGSVGRVFEEWGDGSRRSRRHSPLWAWLKGDHRIRPSRSSQSAMLRSLVPR
uniprot
proteins
function
FUNCTION: Functions as a cytokine that uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST) (By similarity). Functionally, regulates many processes including cell proliferation, cell differentiation, cytokine production (PubMed:15743783). Mechanistically, low affinity ligand binding to IL6ST/gp130, induces heterodimerization with LIFR or OSMR, activating JAK tyrosine kinases (JAK1 or JAK2 and to a lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR or OSMR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of STAT3. The type II OSM complex receptor is also able in addition to STAT3 to recruit STAT5B. Moreover, the type II OSM complex receptor recruits SHC1 through OSMR in a JAK1 mediated phosphotyrosine-dependent manner, leading to SHC1 association with GRB2 and downstream activation of the Ras/Raf/MAPK pathway (By similarity). {ECO:0000250|UniProtKB:P13725, ECO:0000269|PubMed:15743783}.
uniprot
proteins
mass_dalton
27106
uniprot
proteins
post_translational_modification
PTM: Propeptide processing is not important for receptor binding activity but may be important for growth-inhibitory activity. {ECO:0000250|UniProtKB:P13725}.
uniprot
proteins
protein_family
LIF/OSM family
uniprot
proteins
pubmed
15743783
uniprot
proteins
sequence_length
239
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P13725}.
uniprot
proteins