Runx3
entrez
12399
canonical
uniprot
Q64131
canonical
ensembl
ENSMUSG00000070691
resolver
ensp
ENSMUSP00000050353
resolver
ensp
ENSMUSP00000113159
resolver
enst
ENSMUST00000056977
resolver
genesymbol
Runx3
resolver
genesymbol_syn
Aml2
resolver
genesymbol_syn
Cbfa3
resolver
genesymbol_syn
Pebp2a3
resolver
uniprot
B2FDG4
resolver
uniprot
F8WHG7
resolver
uniprot
Q3U1Q3
resolver
uniprot
Q99P92
resolver
uniprot
Q9R199
resolver
uniprot_entry
F8WHG7_MOUSE
resolver
uniprot_entry
Q3U1Q3_MOUSE
resolver
uniprot_entry
RUNX3_MOUSE
resolver
uniprot_sec
B2FDG4
resolver
uniprot_sec
Q99P92
resolver
uniprot_sec
Q9R199
resolver
amino_acid_sequence
MRIPVDPSTSRRFTPPSTAFPCGGGGGGKMGENSGALSAQATAGPGGRTRPEVRSMVDVLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREPRRHRQKIEDQTKAFPDRFGDLRMRVTPSTPSPRGSLSTTSHFSSQAQTPIQGSSDLNPFSDPRQFDRSFPTLQSLTESRFPDPRMHYPGAMSAAFPYSATPSGTSLGSLSVAGMPASSRFHHTYLPPPYPGAPQSQSGPFQANPAPYHLFYGASSGSYQFSMAAAGGGERSPTRMLTSCPSGASVSAGNLMNPSLGQADGVEADGSHSNSPTALSTPGRMDEAVWRPY
uniprot
proteins
function
FUNCTION: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (By similarity). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917). CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (PubMed:23481257). Necessary for the development and survival of sensory neurons expressing parvalbumin (PubMed:39919739). {ECO:0000250|UniProtKB:Q13761, ECO:0000269|PubMed:18258917, ECO:0000269|PubMed:23481257, ECO:0000269|PubMed:39919739, ECO:0000305}.
uniprot
proteins
mass_dalton
43518
uniprot
proteins
mutagenesis
MUTAGEN 405..409; /note="Missing: Inhibits repression of ZBTB7B expression."; /evidence="ECO:0000269|PubMed:23481257
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
11733147
uniprot
proteins
pubmed
16651517
uniprot
proteins
pubmed
18258917
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21151104
uniprot
proteins
pubmed
23481257
uniprot
proteins
pubmed
39919739
uniprot
proteins
pubmed
7607689
uniprot
proteins
pubmed
7607690
uniprot
proteins
sequence_length
409
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13761}. Cytoplasm {ECO:0000250|UniProtKB:Q13761}. Note=The tyrosine phosphorylated form localizes to the cytoplasm. Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. {ECO:0000250|UniProtKB:Q13761}.
uniprot
proteins