Pla2g2a
entrez
29692
canonical
uniprot
P14423
canonical
ensembl
ENSRNOG00000016945
resolver
ensembl
ENSRNOG00055022870
resolver
ensembl
ENSRNOG00060031914
resolver
ensp
ENSRNOP00000022827
resolver
ensp
ENSRNOP00055031846
resolver
ensp
ENSRNOP00060045784
resolver
enst
ENSRNOT00000022827
resolver
enst
ENSRNOT00055039261
resolver
enst
ENSRNOT00060055340
resolver
genesymbol
Pla2g2a
resolver
uniprot_entry
PA2GA_RAT
resolver
amino_acid_sequence
MKVLLLLAVVIMAFGSIQVQGSLLEFGQMILFKTGKRADVSYGFYGCHCGVGGRGSPKDATDWCCVTHDCCYNRLEKRGCGTKFLTYKFSYRGGQISCSTNQDSCRKQLCQCDKAAAECFARNKKSYSLKYQFYPNKFCKGKTPSC
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration (By similarity). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:3356705). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane. Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes. Simultaneously, by compromising mitochondrial membrane integrity, promotes the release in circulation of potent damage-associated molecular pattern molecules that activate the innate immune response (By similarity). Plays a stem cell regulator role in the intestinal crypt. Within intracellular compartment mediates Paneth cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ICS). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ICS cells and tissue regeneration (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner (By similarity). {ECO:0000250|UniProtKB:P14555, ECO:0000250|UniProtKB:P31482, ECO:0000269|PubMed:3356705}.
uniprot
proteins
mass_dalton
16294
uniprot
proteins
protein_family
Phospholipase A2 family
uniprot
proteins
pubmed
2346480
uniprot
proteins
pubmed
2400792
uniprot
proteins
pubmed
2606907
uniprot
proteins
pubmed
2722857
uniprot
proteins
pubmed
2764915
uniprot
proteins
pubmed
3235451
uniprot
proteins
pubmed
3356705
uniprot
proteins
pubmed
3654593
uniprot
proteins
sequence_length
146
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2722857}. Cell membrane {ECO:0000269|PubMed:2722857}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14555}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P14555}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14555}.
uniprot
proteins