Errfi1
entrez
313729
canonical
uniprot
P05432
canonical
ensembl
ENSRNOG00000058186
resolver
ensembl
ENSRNOG00055014174
resolver
ensp
ENSRNOP00000072811
resolver
genesymbol
Errfi1
resolver
genesymbol_syn
33
resolver
genesymbol_syn
Mig6
resolver
uniprot_entry
ERRFI_RAT
resolver
amino_acid_sequence
MSTAGVAAQDIRVPLKTGFLHNGQALGNMKTCWGSRNEFEKNFLNIDPITMAYNLNSPAPEHLTTLGCASPSAPGSGHFFAERGPSPKSSLPPLVIPPSESSGQREEDQVLCGFKKLSVNGVCASTPPLTPIQSCSSPFPCAAPCDRSSRPLPPLPISEDPSLDEADCEVEFLTSADTDFLLEDCVPSDFKYDVPGRRSFRGCGQINYAYFDSPTVSVADLSCASDQNRVVPDPNPPPPQSHRRLRRSHSGPAGSFNKPAIRISSCTHRASPSSDEDKPEIPPRVPIPPRPAKPDYRRWSAEVTSNTYSDEDRPPKVPPREPLSRSNSRTPSPKSLPSYLNGVMPPTQSFAPDPKYVSSKALQRQSSEGSAKAPCILPIIENGKKVSSTHYYLLPERPPYLDKYEKYFREAEEANPSTQIQPLPAACGMVSATDKLASRMKMDVGGHGKRKHLSYVVSP
uniprot
proteins
function
FUNCTION: Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250, ECO:0000269|PubMed:11003669, ECO:0000269|PubMed:17599051}.
uniprot
proteins
mass_dalton
49941
uniprot
proteins
protein_family
MIG6 family
uniprot
proteins
pubmed
11003669
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17599051
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2780291
uniprot
proteins
pubmed
2916834
uniprot
proteins
pubmed
3224831
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity). {ECO:0000250}.
uniprot
proteins