Cobl
entrez
12808
canonical
uniprot
Q5NBX1
canonical
ensembl
ENSMUSG00000020173
resolver
ensp
ENSMUSP00000045693
resolver
ensp
ENSMUSP00000105277
resolver
ensp
ENSMUSP00000105278
resolver
ensp
ENSMUSP00000133470
resolver
ensp
ENSMUSP00000165477
resolver
ensp
ENSMUSP00000165478
resolver
ensp
ENSMUSP00000165479
resolver
ensp
ENSMUSP00000165481
resolver
ensp
ENSMUSP00000165482
resolver
ensp
ENSMUSP00000165490
resolver
ensp
ENSMUSP00000165495
resolver
enst
ENSMUST00000109651
resolver
enst
ENSMUST00000174874
resolver
genesymbol
Cobl
resolver
genesymbol_syn
Kiaa0633
resolver
uniprot
G3UWY3
resolver
uniprot
G5E8P4
resolver
uniprot
Q5NBX2
resolver
uniprot
Q60859
resolver
uniprot
Q6PAT4
resolver
uniprot
Q7TQM9
resolver
uniprot
Q80TV4
resolver
uniprot
Q8C7Q0
resolver
uniprot
Q8CE81
resolver
uniprot
Q8CIM4
resolver
uniprot_entry
COBL_MOUSE
resolver
uniprot_entry
G3UWY3_MOUSE
resolver
uniprot_entry
G5E8P4_MOUSE
resolver
uniprot_sec
Q5NBX2
resolver
uniprot_sec
Q60859
resolver
uniprot_sec
Q6PAT4
resolver
uniprot_sec
Q7TQM9
resolver
uniprot_sec
Q80TV4
resolver
uniprot_sec
Q8C7Q0
resolver
uniprot_sec
Q8CE81
resolver
uniprot_sec
Q8CIM4
resolver
amino_acid_sequence
MDAPRALAAKPPTGRKMKARAPPPPGKPAAQNVHSEQKLPHDATLGSQQSLVYMKEALQNSTLDITVVLPSGLEKQSVVSGSHAMMDLLVELCLQNHLNPSHHVLEIWSSETQQPLSFKPNTLIGSLNVHTVLLKEKVPEERVKPGLTKAPEKSVRLVVNYLRTQKAVVRVSPEVPLQNILPVICAKCEVNPEHVILLRDNVAGEELELSKSLNELGIKELYAWDNRREMFRKSSLGNDETDKEKKKFLGFFKANKRSNSKAEHLGLSGADSDEDPAKSASGGDLNGCVTTPNSPSLHSRSLTLGPSLSLGNISGVSMKSDMKKRRAPPPPSPKLLGQDKVSEKASLSSQADLQKKKRRAPAPPPPQQPPPSPVVPNRKEDKEENRKSTVGVGRQVPQKPPRGTARGPPQLVLPPPPPYPPPDTDVTEPVTFPGEGAGSETSELRPKLSLPLGPGSHCSMGGVSQVPAESEETASEDTTEDSGVMSSPSDAISLDSQQDSMRSKDKWSTDQEDGSDQDLAGTPELGPQKSPSWGKSGSGSSILRTEKATMPTNDDEDLFITGHLHQTLAELDEDLEGMEENYETDTSSLTNSVNGVSNHSLQEAIIPDSGVDDIPVTFIGEVSDEPFDSGLFSSRCNNATTFNTGSIASQRSHLSPSQTEHSQPFVRTSRKEPDPSPPSQDNRKRNQPTLANTSENENPVETDPTVTSLVSKLLIDDPKAKDKGKVHGSSHSEKTQAGHGINSLRVNPRDGKDESSNSAPPPWSHHGQALGGSYGLKYGLTTYKIVPPKSEMRCYDRDVSLSTGAIKIDELGNLVSPHMNGSRTISPPSAVVETDTPPIGKVKEFWRRNSMEKYLNGPAECTIKRAPSTTITATPEKPQQDNGMKAAFTVTTPQQQPASQEYGAHLEEERSRPQSAVSCSVKVPASNPTDITFLKPQRRTSSQYVASAIAKKMGPPKVHADVVRPHKATTEQCHEEAKLARSPPTRKDDAAPNLHSEARQHEHGTNQSSVCLPSNPGVQLPAGGHPKVEVNSTYGKSSTQDYPAAVHRNSYFLPGRSSHRDRVSVGQSCGFNEKQTTSNQKANSTSNFSQALDKAHPPPLLLAEARDSGRILMNGSARTPGNCEPPHSPKESTLTSYIILQTEEKPSSLSTDGQDADDTLPSSIFGPKKKFKPVIQRPLPKDVSLHSALMEAIHSSGGREKLRKTAEQTSEGRPKKPSYVEAESERSALLAAIRGHSGTLSLRKVSSLASEELQSFRNAALGAPGLDKPQQEDLGLPPPPALPPPPAPAPQAPSASVTVSRFSTGTPSNSVNARQALMDAIRSGTGAARLRKVPLLV
uniprot
proteins
function
FUNCTION: Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells. {ECO:0000269|PubMed:17956734, ECO:0000269|PubMed:23223303}.
uniprot
proteins
mass_dalton
143865
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
14512015
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17956734
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23009842
uniprot
proteins
pubmed
23223303
uniprot
proteins
pubmed
7586755
uniprot
proteins
sequence_length
1337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton. Cell projection, ruffle. Cytoplasm. Note=Recruited to the cell membrane via interaction with PACSIN1 (By similarity). Colocalizes with the actin cytoskeleton. Detected throughout the neuron cell body, as well as in axons and dendrites. {ECO:0000250}.
uniprot
proteins