Adam7
entrez
29641
canonical
uniprot
Q63180
canonical
ensembl
ENSRNOG00000014054
resolver
ensp
ENSRNOP00000019209
resolver
enst
ENSRNOT00000019209
resolver
genesymbol
Adam7
resolver
genesymbol_syn
Eapi
resolver
uniprot
G3V7T7
resolver
uniprot_entry
ADAM7_RAT
resolver
uniprot_entry
G3V7T7_RAT
resolver
amino_acid_sequence
MFPTGIFLMSVLISQMQGRGIVGVEGQELVHPKKLSLLQKRDLERIHDSDTPEEYEEELLYEIKLGRKTLTLHLLKAREFLALNYSETYYNIKREMVTRHPQILDHCFYQGSIIHEFDSAASISTCNGLRGFFRVNDQRYLIEPVKYSDEGDHLVFKYNVKAPYATNYSCEGLNFTKKSTLIDAKIIEEHKVEDYHKEKFIELFVVADEFVYRRNSKPQNKLRKRIWGMVNFVNMIYKALNIRVTLTGMEIWSAGDEIEIVSNLESTLLHFSTWQETVLKKRKDFDHVILLSGKWLYTSMQGIAYPGGICQTLRSCSVVKDLLPDVNIIGNRMAHQLGHSLGMRHDDFPCTCPLGKCVMGAGSIPAIKFSKCSQTQYQQFLKNQKPACILNNPLPEEFNDYPFCGNKKVDEGEECDCGPVQECTNPCCDAHKCVLKPGFTCVEGECCESCQMKKEGVICRPAKNECDISEVCTGYSPECPKDESQANGFPCKNGEGYCFMGLCPTRDDQCAELFSGGAEESHSLCYRMNQKGNRFGYCKNKDNTFVPCEEKDLKCGKIYCTGGRRSAHLGEDKTYNLKNVKQNISIKCKTMFLYHNSRDMGLVNSGTKCGEGMVCSNGECIEMEKAYNSTICSSLCDENDVDDNEPDCQCEEGPIITEWGEALNLTSVSIMVVVLVMVIIGVGLVILLIRYQKCIKMKQVQSSSREIRGIENKVYFPDEHQTRSEPIFTDIYPLHNTAESLERVPSTFSSPHYITLKSVSKDPRGIADPKQNDNMNLNLDSQSDCTRLG
uniprot
proteins
function
FUNCTION: Required for normal male fertility via maintenance of epithelial cell morphology in the caput epididymis and subsequently correct epididymis lumen structure required for sperm development (By similarity). Plays a role in sperm motility, flagella morphology and tyrosine phosphorylation during sperm capacitance (By similarity). Plays a role in normal expression levels of HSPA5, ITM2B and ADAM2 in sperm both prior to and post-capacitation (By similarity). This is a non catalytic metalloprotease-like protein (By similarity). {ECO:0000250|UniProtKB:O35227}.
uniprot
proteins
mass_dalton
89362
uniprot
proteins
pubmed
1417724
uniprot
proteins
sequence_length
789
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 669..689; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins