PMCH
entrez
5367
canonical
uniprot
P20382
canonical
ensembl
ENSG00000183395
resolver
ensp
ENSP00000332225
resolver
enst
ENST00000329406
resolver
genesymbol
PMCH
resolver
genesymbol_syn
MCH
resolver
hgnc
HGNC:9109
resolver
uniprot
Q16044
resolver
uniprot
Q8WVG0
resolver
uniprot_entry
MCH_HUMAN
resolver
uniprot_sec
Q16044
resolver
uniprot_sec
Q8WVG0
resolver
amino_acid_sequence
MAKMNLSSYILILTFSLFSQGILLSASKSIRNLDDDMVFNTFRLGKGFQKEDTAEKSVIAPSLEQYKNDESSFMNEEENKVSKNTGSKHNFLNHGLPLNLAIKPYLALKGSVAFPAENGVQNTESTQEKREIGDEENSAKFPIGRRDFDMLRCMLGRVYRPCWQV
uniprot
proteins
function
FUNCTION: [Melanin-concentrating hormone]: Neuropeptide ligand for the G protein-coupled receptor MCHR1 and MCHR2 that can activate both G(i/o)- and G(q/11)-dependent signaling pathways (PubMed:15340116, PubMed:38710677, PubMed:39616153). Acts as a neuromodulator in the central nervous system, promoting feeding, positive energy balance (orexigenic) and sleep. Inhibits stimulated ACTH release (lowering plasma glucocorticoids), consistent with a role in down-regulating hypothalamic-pituitary-adrenal (HPA) axis activity. Functionally antagonizes melanotropin alpha (alpha-MSH), opposing its inhibitory effect on food intake and exploratory behaviors and its stimulatory effect on the HPA axis. Antagonizes NEI-induced behavioral effects (By similarity). May also participate in spermatocyte differentiation (By similarity). {ECO:0000250|UniProtKB:P14200, ECO:0000250|UniProtKB:P56942, ECO:0000269|PubMed:15340116, ECO:0000269|PubMed:38710677, ECO:0000269|PubMed:39616153}.; FUNCTION: [Neuropeptide-glutamic acid-isoleucine]: Neuropeptide that modulates stress-related neuroendocrine responses and behaviors. Stimulates ACTH secretion, functionally counteracting the ACTH-suppressing action of MCH; the underlying mechanism is not fully characterized. Reduces dopamine and DOPAC release in the ventromedial nucleus. Influences differentiation of neuronal processes and affects neurofilament protein content in vitro. {ECO:0000250|UniProtKB:P14200}.
uniprot
proteins
mass_dalton
18679
uniprot
proteins
post_translational_modification
PTM: Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. {ECO:0000269|PubMed:10037747}.
uniprot
proteins
protein_family
Melanin-concentrating hormone family
uniprot
proteins
pubmed
10037747
uniprot
proteins
pubmed
15340116
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2149166
uniprot
proteins
pubmed
38710677
uniprot
proteins
pubmed
39616153
uniprot
proteins
pubmed
8326825
uniprot
proteins
pubmed
9191099
uniprot
proteins
sequence_length
165
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Melanin-concentrating hormone]: Secreted {ECO:0000305|PubMed:15340116, ECO:0000305|PubMed:38710677, ECO:0000305|PubMed:39616153}.; SUBCELLULAR LOCATION: [Neuropeptide-glutamic acid-isoleucine]: Secreted {ECO:0000250|UniProtKB:P14200}.
uniprot
proteins