DHX34
entrez
9704
canonical
uniprot
Q14147
canonical
ensembl
ENSG00000134815
resolver
ensp
ENSP00000331907
resolver
ensp
ENSP00000520696
resolver
ensp
ENSP00000594328
resolver
ensp
ENSP00000635148
resolver
ensp
ENSP00000739376
resolver
enst
ENST00000328771
resolver
enst
ENST00000718252
resolver
enst
ENST00000924269
resolver
enst
ENST00000965089
resolver
genesymbol
DHX34
resolver
genesymbol_syn
DDX34
resolver
genesymbol_syn
KIAA0134
resolver
hgnc
HGNC:16719
resolver
uniprot
B4DMY8
resolver
uniprot_entry
DHX34_HUMAN
resolver
uniprot_sec
B4DMY8
resolver
amino_acid_sequence
MPPPRTREGRDRRDHHRAPSEEEALEKWDWNCPETRRLLEDAFFREEDYIRQGSEECQKFWTFFERLQRFQNLKTSRKEEKDPGQPKHSIPALADLPRTYDPRYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPRPFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVLQMKSMSVGDPRTFPFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRALHQLKRQHEEGAGRRRKVLRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLAQLQAAASSAQDLSREQLALLKLVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQAKQGAVLHPTCVFAGSPEVLHAQELEASNCDGSRDDKDKMSSKHQLLSFVSLLETNKPYLVNCVRIPALQSLLLFSRSLDTNGDCSRLVADGWLELQLADSESAIRLLAASLRLRARWESALDRQLAHQAQQQLEEEEEDTPVSPKEVATLSKELLQFTASKIPYSLRRLTGLEVQNMYVGPQTIPATPHLPGLFGSSTLSPHPTKGGYAVTDFLTYNCLTNDTDLYSDCLRTFWTCPHCGLHAPLTPLERIAHENTCPQAPQDGPPGAEEAALETLQKTSVLQRPYHCEACGKDFLFTPTEVLRHRKQHV
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Probable ATP-binding RNA helicase required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons (PubMed:25220460, PubMed:33205750). Promotes the phosphorylation of UPF1 along with its interaction with key NMD pathway proteins UPF2 and EIF4A3 (PubMed:25220460). Interaction with the RUVBL1-RUVBL2 complex results in loss of nucleotide binding ability and ATP hydrolysis of the complex (PubMed:33205750). Negatively regulates the nucleotide binding ability and ATP hydrolysis of the RUVBL1-RUVBL2 complex via induction of N-terminus conformation changes of the RUVBL2 subunits (PubMed:33205750). {ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:33205750}.
uniprot
proteins
mass_dalton
128120
uniprot
proteins
mutagenesis
MUTAGEN 191; /note="K->S: Results in interaction with ETF1/eRF1, GSPT1/eRF3a and GSPT2/eRF3b. Reduces UPF1 phosphorylation. No effect on mRNA binding or interaction with SMG1."; /evidence="ECO:0000269|PubMed:25220460"; MUTAGEN 279; /note="D->A: Results in interaction with ETF1/eRF1, GSPT1/eRF3a and GSPT2/eRF3b. Increases mRNA binding. Reduces UPF1 phosphorylation. Reduces ATPase activity. No effect on interaction with SMG1."; /evidence="ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:26841701, ECO:0000269|PubMed:33205750
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
protein_family
DEAH subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25220460
uniprot
proteins
pubmed
26841701
uniprot
proteins
pubmed
31256877
uniprot
proteins
pubmed
33205750
uniprot
proteins
pubmed
8590280
uniprot
proteins
sequence_length
1143
uniprot
proteins