NIFK
entrez
84365
canonical
uniprot
Q9BYG3
canonical
ensembl
ENSG00000155438
resolver
ensp
ENSP00000285814
resolver
enst
ENST00000285814
resolver
genesymbol
NIFK
resolver
genesymbol_syn
MKI67IP
resolver
genesymbol_syn
NOPP34
resolver
hgnc
HGNC:17838
resolver
uniprot
A8K788
resolver
uniprot
Q8TB66
resolver
uniprot
Q96ED4
resolver
uniprot_entry
MK67I_HUMAN
resolver
uniprot_sec
A8K788
resolver
uniprot_sec
Q8TB66
resolver
uniprot_sec
Q96ED4
resolver
amino_acid_sequence
MATFSGPAGPILSLNPQEDVEFQKEVAQVRKRITQRKKQEQLTPGVVYVRHLPNLLDETQIFSYFSQFGTVTRFRLSRSKRTGNSKGYAFVEFESEDVAKIVAETMNNYLFGERLLECHFMPPEKVHKELFKDWNIPFKQPSYPSVKRYNRNRTLTQKLRMEERFKKKERLLRKKLAKKGIDYDFPSLILQKTESISKTNRQTSTKGQVLRKKKKKVSGTLDTPEKTVDSQGPTPVCTPTFLERRKSQVAELNDDDKDDEIVFKQPISCVKEEIQETQTPTHSRKKRRRSSNQ
uniprot
proteins
mass_dalton
34222
uniprot
proteins
mutagenesis
MUTAGEN 230; /note="S->A: Loss of phosphorylation site."; /evidence="ECO:0000269|PubMed:16244663"; MUTAGEN 234; /note="T->A: Loss of phosphorylation site. Abrogates interaction with MKI67."; /evidence="ECO:0000269|PubMed:11342549, ECO:0000269|PubMed:16244663"; MUTAGEN 235; /note="P->A: Reduces phosphorylation at T-234."; /evidence="ECO:0000269|PubMed:16244663"; MUTAGEN 238; /note="T->A: Loss of phosphorylation site. Abrogates interaction with MKI67."; /evidence="ECO:0000269|PubMed:11342549, ECO:0000269|PubMed:16244663"; MUTAGEN 239; /note="P->A: Reduces phosphorylation at T-234 and T-238."; /evidence="ECO:0000269|PubMed:16244663
uniprot
proteins
post_translational_modification
PTM: Sequentially phosphorylated on Thr-238, Thr-234 and Ser-230. Thr-234 is phosphorylated only when Thr-238 is phosphorylated. Likewise, phosphorylation at Ser-230 requires that Thr-234 and Thr-238 are phosphorylated. Phosphorylation enhances MKI67 binding. {ECO:0000269|PubMed:11342549, ECO:0000269|PubMed:14659764, ECO:0000269|PubMed:16244663}.
uniprot
proteins
pubmed
11342549
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
14659764
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16244663
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
26529540
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
293
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus. Chromosome. Note=Localizes to mitotic chromosomes in conjunction with MKI67.
uniprot
proteins