SLCO2B1
entrez
11309
canonical
uniprot
O94956
canonical
ensembl
ENSG00000137491
resolver
ensp
ENSP00000289575
resolver
ensp
ENSP00000388912
resolver
ensp
ENSP00000436324
resolver
enst
ENST00000525650
resolver
genesymbol
SLCO2B1
resolver
genesymbol_syn
KIAA0880
resolver
genesymbol_syn
OATP2B1
resolver
genesymbol_syn
OATPB
resolver
genesymbol_syn
SLC21A9
resolver
hgnc
HGNC:10962
resolver
uniprot
A0A024R5I4
resolver
uniprot
A0A0A0MTF1
resolver
uniprot
A8K2G9
resolver
uniprot
B4DGA9
resolver
uniprot
B4DTB0
resolver
uniprot
E7ERN5
resolver
uniprot
E9PPU8
resolver
uniprot
Q9H2Z0
resolver
uniprot
Q9UFU1
resolver
uniprot_entry
A0A0A0MTF1_HUMAN
resolver
uniprot_entry
SO2B1_HUMAN
resolver
uniprot_sec
A0A024R5I4
resolver
uniprot_sec
A8K2G9
resolver
uniprot_sec
B4DGA9
resolver
uniprot_sec
B4DTB0
resolver
uniprot_sec
E7ERN5
resolver
uniprot_sec
E9PPU8
resolver
uniprot_sec
Q9H2Z0
resolver
uniprot_sec
Q9UFU1
resolver
activity_regulation
ACTIVITY REGULATION: E1S, DHEA-S and PregS transports are regulated by steroid hormones. In the case of testosterone, transport of E1S and DHEA-S was inhibited, whereas progesterone stimulated E1S, DHEA-S and PregS uptake (PubMed:16908597). Progesterone stimulates high-affinity uptake of E1S whereas it inhibits low-affinity uptake of E1S (Ref.25). Progesterone doesn't affect the uptake of PGE2 (Ref.25). {ECO:0000269|PubMed:16908597, ECO:0000269|Ref.25}.
uniprot
proteins
amino_acid_sequence
MGPRIGPAGEVPQVPDKETKATMGTENTPGGKASPDPQDVRPSVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTSPEDMPQDFKASLCLPTTSAPASAPSNGNCSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGITHQTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCVVEGNPVLAGSCDSTCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHWALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGSVICFALVLAVLRQQDKEARTKESRSSPAVEQQLLVSGPGKKPEDSRV
uniprot
proteins
function
FUNCTION: Mediates the Na(+)-independent transport of steroid sulfate conjugates and other specific organic anions (PubMed:10873595, PubMed:11159893, PubMed:11932330, PubMed:12724351, PubMed:14610227, PubMed:16908597, PubMed:18501590, PubMed:20507927, PubMed:22201122, PubMed:23531488, PubMed:25132355, PubMed:26383540, PubMed:27576593, PubMed:28408210, PubMed:29871943, PubMed:34628357). Responsible for the transport of estrone 3-sulfate (E1S) through the basal membrane of syncytiotrophoblast, highlighting a potential role in the placental absorption of fetal-derived sulfated steroids including the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S) (PubMed:11932330, PubMed:12409283). Also facilitates the uptake of sulfated steroids at the basal/sinusoidal membrane of hepatocytes, therefore accounting for the major part of organic anions clearance of liver (PubMed:11159893). Mediates the intestinal uptake of sulfated steroids (PubMed:12724351, PubMed:28408210). Mediates the uptake of the neurosteroids DHEA-S and pregnenolone sulfate (PregS) into the endothelial cells of the blood-brain barrier as the first step to enter the brain (PubMed:16908597, PubMed:25132355). Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (PubMed:25132355). May act as a heme transporter that promotes cellular iron availability via heme oxygenase/HMOX2 and independently of TFRC (PubMed:35714613). Also transports heme by-product coproporphyrin III (CPIII), and may be involved in their hepatic disposition (PubMed:26383540). Mediates the uptake of other substrates such as prostaglandins D2 (PGD2), E1 (PGE1) and E2 (PGE2), taurocholate, L-thyroxine, leukotriene C4 and thromboxane B2 (PubMed:10873595, PubMed:14610227, PubMed:19129463, PubMed:29871943, Ref.25). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:14610227, PubMed:19129463, PubMed:22201122). The exact transport mechanism has not been yet deciphered but most likely involves an anion exchange, coupling the cellular uptake of organic substrate with the efflux of an anionic compound (PubMed:19129463, PubMed:20507927, PubMed:26277985). Hydrogencarbonate/HCO3(-) acts as a probable counteranion that exchanges for organic anions (PubMed:19129463). Cytoplasmic glutamate may also act as counteranion in the placenta (PubMed:26277985). An inwardly directed proton gradient has also been proposed as the driving force of E1S uptake with a (H(+):E1S) stoichiometry of (1:1) (PubMed:20507927). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:11932330, ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:12724351, ECO:0000269|PubMed:14610227, ECO:0000269|PubMed:16908597, ECO:0000269|PubMed:18501590, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20507927, ECO:0000269|PubMed:22201122, ECO:0000269|PubMed:23531488, ECO:0000269|PubMed:25132355, ECO:0000269|PubMed:26277985, ECO:0000269|PubMed:26383540, ECO:0000269|PubMed:27576593, ECO:0000269|PubMed:29871943, ECO:0000269|PubMed:34628357, ECO:0000269|PubMed:35714613, ECO:0000269|Ref.25, ECO:0000305|PubMed:35307651}.; FUNCTION: [Isoform 3]: Has estrone 3-sulfate (E1S) transport activity comparable with the full-length isoform 1. {ECO:0000269|PubMed:23531488}.
uniprot
proteins
mass_dalton
76699
uniprot
proteins
mutagenesis
MUTAGEN 46; /note="H->Q: No change in low- and high-affinity transport of E1S."; /evidence="ECO:0000269|Ref.25"; MUTAGEN 49; /note="K->A: Decreased E1S transport, no change in cell surface expression."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 50; /note="L->A: No change in E1S transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 51; /note="F->A: Decreased E1S transport; decreased cell surface expression; no change in Km and Vmax values. Decreased taurocholate transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 51; /note="F->Y: Decreased E1S transport; decreased cell surface expression."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 52; /note="V->A: Decreased E1S transport, decreased cell surface expression; no change in Km value and decreased Vmax value. Decreased taurocholate transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 52; /note="V->I: Decreased E1S transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 53; /note="L->A: No change in E1S transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 54; /note="C->A: No change in E1S transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 55; /note="H->A: Decreased E1S transport, decreased cell surface expression; no change in Km value and decreased Vmax value for E1S transport activity. Decreased taurocholate transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 55; /note="H->K: Decreased E1S transport; decreased cell surface expression."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 55; /note="H->Q: Decreased low- and high-affinity transport of E1S."; /evidence="ECO:0000269|Ref.25"; MUTAGEN 56; /note="S->A: Decreased E1S transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 57; /note="L->A: Decreased E1S transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 58; /note="L->A: Decreased E1S transport, no change in cell surface expression; increased Km value and decreased Vmax value for E1S transport activity. Decreased taurocholate transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 58; /note="L->I: Decreased E1S transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 59; /note="Q->A: Decreased E1S transport, no change in cell surface expression; no change in Km value and decreased Vmax value for E1S transport activity. Decreased taurocholate transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 59; /note="Q->N: Decreased E1S transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 60; /note="L->A: No change in E1S transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 61; /note="A->V: Decreased E1S transport, no change in cell surface expression, increased Km value and decreased Vmax value for E1S transport activity. Decreased taurocholate transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 62; /note="Q->A: Decreased E1S transport, no change in cell surface expression; no change in Km value and decreased Vmax value for E1S transport activity. Decreased taurocholate transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 62; /note="Q->N: Decreased E1S transport; no change in cell surface expression."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 63; /note="L->A: Decreased E1S transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 64; /note="M->A: No change in E1S transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 65; /note="I->A: Decreased E1S transport, no change in cell surface expression."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 66; /note="S->A: Decreased E1S transport, no change in cell surface expression, increased Km value and decreased Vmax value for E1S transport activity. Decreased taurocholate transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 66; /note="S->T: Decreased E1S transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 67; /note="G->A: Decreased E1S transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 68; /note="Y->A: No change in E1S transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 69; /note="L->A: Decreased E1S transport, no change in cell surface expression; no change in Km value and decreased Vmax value for E1S transport activity. Decreased taurocholate transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 69; /note="L->I: Decreased E1S transport."; /evidence="ECO:0000269|PubMed:29871943"; MUTAGEN 113; /note="H->Q: Decreased low-affinity transport of E1S; no change in high-affinity transport of E1S."; /evidence="ECO:0000269|Ref.25"; MUTAGEN 136; /note="H->Q: Decreased low-affinity transport of E1S; no change in high-affinity transport of E1S."; /evidence="ECO:0000269|Ref.25"; MUTAGEN 185; /note="H->Q: Increased low- and high-affinity transport of E1S."; /evidence="ECO:0000269|Ref.25"; MUTAGEN 219; /note="H->Q: Decreased low- and high-affinity transport of E1S."; /evidence="ECO:0000269|Ref.25"; MUTAGEN 272; /note="W->A: Decreased E1S transport; decreased cell surface expression. Strong decrease in cell surface expression; when associated with A-276 and A-277."; /evidence="ECO:0000269|PubMed:27576593"; MUTAGEN 272; /note="W->F: No change in E1S transport; decreased cell surface expression."; /evidence="ECO:0000269|PubMed:27576593"; MUTAGEN 276; /note="W->A: Decreased E1S transport; decreased cell surface expression. Strong decrease in cell surface expression; when associated with A-272 and A-277."; /evidence="ECO:0000269|PubMed:27576593"; MUTAGEN 276; /note="W->F: Decreased E1S transport; decreased cell surface expression."; /evidence="ECO:0000269|PubMed:27576593"; MUTAGEN 277; /note="W->A: Decreased E1S transport; decreased cell surface expression. Strong decrease in cell surface expression; when associated with A-272 and A-276."; /evidence="ECO:0000269|PubMed:27576593"; MUTAGEN 277; /note="W->F: Decreased E1S transport; decreased cell surface expression."; /evidence="ECO:0000269|PubMed:27576593"; MUTAGEN 370; /note="H->Q: No change in low- and high-affinity transport of E1S."; /evidence="ECO:0000269|Ref.25"; MUTAGEN 436; /note="H->Q: Decreased low-affinity transport of E1S; no change in high affinity transport of E1S."; /evidence="ECO:0000269|Ref.25"; MUTAGEN 468; /note="H->Q: Decreased high-affinity transport of E1S; no change in low-affinity transport of E1S."; /evidence="ECO:0000269|Ref.25"; MUTAGEN 475; /note="H->Q: Increased high-affinity transport of E1S; decreased low-affinity transport of E1S."; /evidence="ECO:0000269|Ref.25"; MUTAGEN 480; /note="H->Q: No change in low- and high-affinity transport of E1S."; /evidence="ECO:0000269|Ref.25"; MUTAGEN 517; /note="H->Q: Decreased low-affinity transport of E1S; no change in high-affinity transport of E1S."; /evidence="ECO:0000269|Ref.25"; MUTAGEN 523; /note="W->A: No change in E1S transport; no change in cell surface expression."; /evidence="ECO:0000269|PubMed:27576593"; MUTAGEN 579; /note="H->Q: Strong decrease in low-affinity and decreased in high-affinity transport of E1S; undetectable kinetic parameter for low-affinity and no change in Vmax/Km value for high-affinity transort. Increased PGE2 transport. Decreased in low- and high-affinity transport of E1S and lower Vmax/Km values; when associated with Q-618."; /evidence="ECO:0000269|Ref.25"; MUTAGEN 607; /note="R->A: Loss of E1S transport; small decrease in cell surface expression. Strong decrease in low-affinity transport of E1S and loss of high-affinity transport of E1S. Decreased PGE2 transport."; /evidence="ECO:0000269|PubMed:27576593, ECO:0000269|Ref.25"; MUTAGEN 611; /note="W->A: Decreased E1S transport; decreased cell surface expression."; /evidence="ECO:0000269|PubMed:27576593"; MUTAGEN 611; /note="W->F: Decreased E1S transport; decreased cell surface expression."; /evidence="ECO:0000269|PubMed:27576593"; MUTAGEN 611; /note="W->H: Decreased E1S transport; decreased cell surface expression."; /evidence="ECO:0000269|PubMed:27576593"; MUTAGEN 611; /note="W->S: Decreased E1S transport; decreased cell surface expression."; /evidence="ECO:0000269|PubMed:27576593"; MUTAGEN 611; /note="W->Y: Decreased E1S transport; decreased cell surface expression."; /evidence="ECO:0000269|PubMed:27576593"; MUTAGEN 618; /note="H->Q: Strong decrease in high-affinity transport of E1S and lower Vmax/Km value; no change in low-affinity transport of E1S and higher Vmax/Km value. No change in PGE2 transport. Decreased in low- and high-affinity transport of E1S and lower Vmax/Km values; when associated with Q-579."; /evidence="ECO:0000269|Ref.25"; MUTAGEN 628; /note="H->Q: Decreased low- and high-affinity transport of E1S."; /evidence="ECO:0000269|Ref.25"; MUTAGEN 629; /note="W->A: No change in E1S transport; decreased cell surface expression."; /evidence="ECO:0000269|PubMed:27576593
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
10873595
uniprot
proteins
pubmed
11159893
uniprot
proteins
pubmed
11932330
uniprot
proteins
pubmed
12409283
uniprot
proteins
pubmed
12724351
uniprot
proteins
pubmed
14610227
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16754786
uniprot
proteins
pubmed
16908597
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18501590
uniprot
proteins
pubmed
19129463
uniprot
proteins
pubmed
20507927
uniprot
proteins
pubmed
22201122
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23531488
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25132355
uniprot
proteins
pubmed
26277985
uniprot
proteins
pubmed
26383540
uniprot
proteins
pubmed
27576593
uniprot
proteins
pubmed
28408210
uniprot
proteins
pubmed
29871943
uniprot
proteins
pubmed
34628357
uniprot
proteins
pubmed
35307651
uniprot
proteins
pubmed
35714613
uniprot
proteins
sequence_length
709
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25132355}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:11932330, ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:28408210}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:12724351, ECO:0000269|PubMed:28408210}; Multi-pass membrane protein {ECO:0000305}. Note=Expressed at the basal membrane of hepatocytes, syncytiotrophoblast and Sertoli cells (PubMed:11159893, PubMed:11932330, PubMed:12409283, PubMed:35307651). Localized to the basolateral membrane of enterocytes (PubMed:28408210). Also found at the apical membrane of enterocytes (PubMed:12724351, PubMed:28408210). {ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:11932330, ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:12724351, ECO:0000269|PubMed:28408210, ECO:0000269|PubMed:35307651}.
uniprot
proteins
transmembrane_region
TRANSMEM 50..69; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 89..109; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 116..140; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 186..215; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 235..255; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 274..298; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 367..388; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 409..432; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 437..460; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 565..587; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 597..622; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 656..673; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins