HLA-DRB1
entrez
3123
canonical
uniprot
P01911
canonical
ensembl
ENSG00000196126
resolver
ensembl
ENSG00000206240
resolver
ensembl
ENSG00000206306
resolver
ensembl
ENSG00000228080
resolver
ensembl
ENSG00000229074
resolver
ensembl
ENSG00000236884
resolver
ensp
ENSP00000331343
resolver
ensp
ENSP00000353099
resolver
ensp
ENSP00000382378
resolver
ensp
ENSP00000403458
resolver
ensp
ENSP00000405960
resolver
ensp
ENSP00000409322
resolver
enst
ENST00000328980
resolver
enst
ENST00000360004
resolver
enst
ENST00000399450
resolver
enst
ENST00000419393
resolver
enst
ENST00000437784
resolver
enst
ENST00000444645
resolver
genesymbol
HLA-DRB1
resolver
hgnc
HGNC:4948
resolver
uniprot
A0A224MM52
resolver
uniprot
A0A5S8K779
resolver
uniprot
A0A5S8K7A4
resolver
uniprot
A0A5S8K7C3
resolver
uniprot
A0MWF2
resolver
uniprot
A0N0W1
resolver
uniprot
A2BFX2
resolver
uniprot
A2ICT1
resolver
uniprot
A2TGX3
resolver
uniprot
A4F5N0
resolver
uniprot
A4ZXA5
resolver
uniprot
A4ZXA6
resolver
uniprot
A4ZY86
resolver
uniprot
A5H000
resolver
uniprot
A5HKN8
resolver
uniprot
A7DZP9
resolver
uniprot
A7LA26
resolver
uniprot
A7UHG2
resolver
uniprot
A7X5B1
resolver
uniprot
A7X5B7
resolver
uniprot
A7X5E0
resolver
uniprot
A7X5E6
resolver
uniprot
A7X5H8
resolver
uniprot
A7X5J4
resolver
uniprot
A7X5K7
resolver
uniprot
A8K098
resolver
uniprot
A8YQE9
resolver
uniprot
A9JPG0
resolver
uniprot
B0BK85
resolver
uniprot
B0LUZ6
resolver
uniprot
B0UYW1
resolver
uniprot
B1GWE7
resolver
uniprot
B2CR03
resolver
uniprot
B2LVF9
resolver
uniprot
B2NJ29
resolver
uniprot
B2ZCY1
resolver
uniprot
B3VTP8
resolver
uniprot
B3VTQ3
resolver
uniprot
B5A8Y2
resolver
uniprot
B5A8Y3
resolver
uniprot
B5B8U0
resolver
uniprot
B5B9V5
resolver
uniprot
B5B9V6
resolver
uniprot
B5LZ25
resolver
uniprot
B5QSK8
resolver
uniprot
B6VCX2
resolver
uniprot
B6VEL9
resolver
uniprot
B7UDB2
resolver
uniprot
B9VRA4
resolver
uniprot
B9X248
resolver
uniprot
C0LAB5
resolver
uniprot
D7RIG5
resolver
uniprot
D7RIH8
resolver
uniprot
G0YWD3
resolver
uniprot
O02876
resolver
uniprot
O02930
resolver
uniprot
O19585
resolver
uniprot
O19717
resolver
uniprot
O19718
resolver
uniprot
O19739
resolver
uniprot
O19788
resolver
uniprot
O46699
resolver
uniprot
O46793
resolver
uniprot
O46872
resolver
uniprot
O62869
resolver
uniprot
O62889
resolver
uniprot
O77969
resolver
uniprot
O78047
resolver
uniprot
O78210
resolver
uniprot
O98212
resolver
uniprot
P01912
resolver
uniprot
P01914
resolver
uniprot
P04229
resolver
uniprot
P13758
resolver
uniprot
P13759
resolver
uniprot
P13760
resolver
uniprot
P13761
resolver
uniprot
P20039
resolver
uniprot
P79545
resolver
uniprot
Q06662
resolver
uniprot
Q0PGR5
resolver
uniprot
Q0PQ39
resolver
uniprot
Q14280
resolver
uniprot
Q14QT2
resolver
uniprot
Q155F7
resolver
uniprot
Q19AF2
resolver
uniprot
Q19K86
resolver
uniprot
Q1AP33
resolver
uniprot
Q1G0Z9
resolver
uniprot
Q1JRP3
resolver
uniprot
Q1KLJ6
resolver
uniprot
Q27PR6
resolver
uniprot
Q27PR7
resolver
uniprot
Q29673
resolver
uniprot
Q29720
resolver
uniprot
Q29722
resolver
uniprot
Q29734
resolver
uniprot
Q29770
resolver
uniprot
Q29771
resolver
uniprot
Q29772
resolver
uniprot
Q29790
resolver
uniprot
Q29792
resolver
uniprot
Q29800
resolver
uniprot
Q29806
resolver
uniprot
Q29833
resolver
uniprot
Q29874
resolver
uniprot
Q29875
resolver
uniprot
Q29886
resolver
uniprot
Q29968
resolver
uniprot
Q29974
resolver
uniprot
Q29975
resolver
uniprot
Q2A120
resolver
uniprot
Q2HZE5
resolver
uniprot
Q2L9H4
resolver
uniprot
Q2LE76
resolver
uniprot
Q2MF40
resolver
uniprot
Q2MJA6
resolver
uniprot
Q2MZ92
resolver
uniprot
Q2VQU1
resolver
uniprot
Q2YHQ2
resolver
uniprot
Q30006
resolver
uniprot
Q30108
resolver
uniprot
Q30112
resolver
uniprot
Q30115
resolver
uniprot
Q30116
resolver
uniprot
Q30117
resolver
uniprot
Q30120
resolver
uniprot
Q30134
resolver
uniprot
Q30142
resolver
uniprot
Q30145
resolver
uniprot
Q30149
resolver
uniprot
Q30159
resolver
uniprot
Q30166
resolver
uniprot
Q30167
resolver
uniprot
Q30200
resolver
uniprot
Q307W5
resolver
uniprot
Q31636
resolver
uniprot
Q32MY7
resolver
uniprot
Q3HUP9
resolver
uniprot
Q3KTM1
resolver
uniprot
Q3LA84
resolver
uniprot
Q3LA87
resolver
uniprot
Q3LA88
resolver
uniprot
Q3LA89
resolver
uniprot
Q3LA90
resolver
uniprot
Q3LA91
resolver
uniprot
Q3LA92
resolver
uniprot
Q3LA93
resolver
uniprot
Q3LA94
resolver
uniprot
Q3LA95
resolver
uniprot
Q3LA96
resolver
uniprot
Q3LA97
resolver
uniprot
Q3LA98
resolver
uniprot
Q3LA99
resolver
uniprot
Q3LAA0
resolver
uniprot
Q3LAA1
resolver
uniprot
Q3LAA2
resolver
uniprot
Q3MQ60
resolver
uniprot
Q3T919
resolver
uniprot
Q4PRC3
resolver
uniprot
Q4PRC5
resolver
uniprot
Q4VZY7
resolver
uniprot
Q53IG1
resolver
uniprot
Q56FN9
resolver
uniprot
Q56FP1
resolver
uniprot
Q56FP2
resolver
uniprot
Q56FP3
resolver
uniprot
Q58F52
resolver
uniprot
Q5BM92
resolver
uniprot
Q5EER6
resolver
uniprot
Q5K3W2
resolver
uniprot
Q5NDB9
resolver
uniprot
Q5U9W6
resolver
uniprot
Q5UBA2
resolver
uniprot
Q5UT58
resolver
uniprot
Q5W3L4
resolver
uniprot
Q5Y7A7
resolver
uniprot
Q5Y7B0
resolver
uniprot
Q5Y7B9
resolver
uniprot
Q5Y7D1
resolver
uniprot
Q5Y7E9
resolver
uniprot
Q5Y7G0
resolver
uniprot
Q683P7
resolver
uniprot
Q6REE2
resolver
uniprot
Q6T865
resolver
uniprot
Q6U387
resolver
uniprot
Q701T1
resolver
uniprot
Q70GL2
resolver
uniprot
Q70Q85
resolver
uniprot
Q768U2
resolver
uniprot
Q768U4
resolver
uniprot
Q7M2H4
resolver
uniprot
Q7YNY9
resolver
uniprot
Q7YP03
resolver
uniprot
Q7YP04
resolver
uniprot
Q7YQ26
resolver
uniprot
Q7YQA3
resolver
uniprot
Q7YQA5
resolver
uniprot
Q860D8
resolver
uniprot
Q860D9
resolver
uniprot
Q860E5
resolver
uniprot
Q860H8
resolver
uniprot
Q860S0
resolver
uniprot
Q860Z3
resolver
uniprot
Q861G6
resolver
uniprot
Q861H0
resolver
uniprot
Q861H4
resolver
uniprot
Q861H5
resolver
uniprot
Q861H7
resolver
uniprot
Q861H8
resolver
uniprot
Q8HWQ6
resolver
uniprot
Q8MH59
resolver
uniprot
Q8MH60
resolver
uniprot
Q8WLU3
resolver
uniprot
Q8WMA0
resolver
uniprot
Q95348
resolver
uniprot
Q95383
resolver
uniprot
Q95389
resolver
uniprot
Q95461
resolver
uniprot
Q95HK1
resolver
uniprot
Q95HL0
resolver
uniprot
Q95HL1
resolver
uniprot
Q95IE3
resolver
uniprot
Q95IG2
resolver
uniprot
Q95IT6
resolver
uniprot
Q96HZ9
resolver
uniprot
Q9BCL7
resolver
uniprot
Q9BCP0
resolver
uniprot
Q9BCP1
resolver
uniprot
Q9BCP2
resolver
uniprot
Q9BCP5
resolver
uniprot
Q9BD21
resolver
uniprot
Q9BD33
resolver
uniprot
Q9BD40
resolver
uniprot
Q9GIK5
resolver
uniprot
Q9GIL5
resolver
uniprot
Q9GIL6
resolver
uniprot
Q9GIP3
resolver
uniprot
Q9GIX8
resolver
uniprot
Q9GIX9
resolver
uniprot
Q9GIY0
resolver
uniprot
Q9GIY1
resolver
uniprot
Q9GIY2
resolver
uniprot
Q9GIY3
resolver
uniprot
Q9GIY4
resolver
uniprot
Q9GJ25
resolver
uniprot
Q9GJ56
resolver
uniprot
Q9GJ57
resolver
uniprot
Q9GJ58
resolver
uniprot
Q9GJ60
resolver
uniprot
Q9GJF8
resolver
uniprot
Q9GJF9
resolver
uniprot
Q9GJG0
resolver
uniprot
Q9MXZ0
resolver
uniprot
Q9MXZ5
resolver
uniprot
Q9MY13
resolver
uniprot
Q9MY45
resolver
uniprot
Q9MY56
resolver
uniprot
Q9MYF5
resolver
uniprot
Q9TPB6
resolver
uniprot
Q9TPW1
resolver
uniprot
Q9TPW3
resolver
uniprot
Q9TPW9
resolver
uniprot
Q9TPX4
resolver
uniprot
Q9TQ37
resolver
uniprot
Q9TQ91
resolver
uniprot
Q9TQE0
resolver
uniprot
Q9UBY1
resolver
uniprot
Q9UIM9
resolver
uniprot
Q9UIN0
resolver
uniprot
Q9XRX1
resolver
uniprot
Q9XRY4
resolver
uniprot
Q9XRY5
resolver
uniprot
Q9Y453
resolver
uniprot
Q9Y4H7
resolver
uniprot
X5DNQ0
resolver
uniprot_entry
A0A224MM52_HUMAN
resolver
uniprot_entry
A0A5S8K779_HUMAN
resolver
uniprot_entry
A0A5S8K7A4_HUMAN
resolver
uniprot_entry
A0A5S8K7C3_HUMAN
resolver
uniprot_entry
A2BFX2_HUMAN
resolver
uniprot_entry
D7RIG5_HUMAN
resolver
uniprot_entry
D7RIH8_HUMAN
resolver
uniprot_entry
DRB1_HUMAN
resolver
uniprot_entry
Q5Y7D1_HUMAN
resolver
uniprot_entry
X5DNQ0_HUMAN
resolver
uniprot_sec
A0MWF2
resolver
uniprot_sec
A0N0W1
resolver
uniprot_sec
A2ICT1
resolver
uniprot_sec
A2TGX3
resolver
uniprot_sec
A4F5N0
resolver
uniprot_sec
A4ZXA5
resolver
uniprot_sec
A4ZXA6
resolver
uniprot_sec
A4ZY86
resolver
uniprot_sec
A5H000
resolver
uniprot_sec
A5HKN8
resolver
uniprot_sec
A7DZP9
resolver
uniprot_sec
A7LA26
resolver
uniprot_sec
A7UHG2
resolver
uniprot_sec
A7X5B1
resolver
uniprot_sec
A7X5B7
resolver
uniprot_sec
A7X5E0
resolver
uniprot_sec
A7X5E6
resolver
uniprot_sec
A7X5H8
resolver
uniprot_sec
A7X5J4
resolver
uniprot_sec
A7X5K7
resolver
uniprot_sec
A8K098
resolver
uniprot_sec
A8YQE9
resolver
uniprot_sec
A9JPG0
resolver
uniprot_sec
B0BK85
resolver
uniprot_sec
B0LUZ6
resolver
uniprot_sec
B0UYW1
resolver
uniprot_sec
B1GWE7
resolver
uniprot_sec
B2CR03
resolver
uniprot_sec
B2LVF9
resolver
uniprot_sec
B2NJ29
resolver
uniprot_sec
B2ZCY1
resolver
uniprot_sec
B3VTP8
resolver
uniprot_sec
B3VTQ3
resolver
uniprot_sec
B5A8Y2
resolver
uniprot_sec
B5A8Y3
resolver
uniprot_sec
B5B8U0
resolver
uniprot_sec
B5B9V5
resolver
uniprot_sec
B5B9V6
resolver
uniprot_sec
B5LZ25
resolver
uniprot_sec
B5QSK8
resolver
uniprot_sec
B6VCX2
resolver
uniprot_sec
B6VEL9
resolver
uniprot_sec
B7UDB2
resolver
uniprot_sec
B9VRA4
resolver
uniprot_sec
B9X248
resolver
uniprot_sec
C0LAB5
resolver
uniprot_sec
G0YWD3
resolver
uniprot_sec
O02876
resolver
uniprot_sec
O02930
resolver
uniprot_sec
O19585
resolver
uniprot_sec
O19717
resolver
uniprot_sec
O19718
resolver
uniprot_sec
O19739
resolver
uniprot_sec
O19788
resolver
uniprot_sec
O46699
resolver
uniprot_sec
O46793
resolver
uniprot_sec
O46872
resolver
uniprot_sec
O62869
resolver
uniprot_sec
O62889
resolver
uniprot_sec
O77969
resolver
uniprot_sec
O78047
resolver
uniprot_sec
O78210
resolver
uniprot_sec
O98212
resolver
uniprot_sec
P01912
resolver
uniprot_sec
P01914
resolver
uniprot_sec
P04229
resolver
uniprot_sec
P13758
resolver
uniprot_sec
P13759
resolver
uniprot_sec
P13760
resolver
uniprot_sec
P13761
resolver
uniprot_sec
P20039
resolver
uniprot_sec
P79545
resolver
uniprot_sec
Q06662
resolver
uniprot_sec
Q0PGR5
resolver
uniprot_sec
Q0PQ39
resolver
uniprot_sec
Q14280
resolver
uniprot_sec
Q14QT2
resolver
uniprot_sec
Q155F7
resolver
uniprot_sec
Q19AF2
resolver
uniprot_sec
Q19K86
resolver
uniprot_sec
Q1AP33
resolver
uniprot_sec
Q1G0Z9
resolver
uniprot_sec
Q1JRP3
resolver
uniprot_sec
Q1KLJ6
resolver
uniprot_sec
Q27PR6
resolver
uniprot_sec
Q27PR7
resolver
uniprot_sec
Q29673
resolver
uniprot_sec
Q29720
resolver
uniprot_sec
Q29722
resolver
uniprot_sec
Q29734
resolver
uniprot_sec
Q29770
resolver
uniprot_sec
Q29771
resolver
uniprot_sec
Q29772
resolver
uniprot_sec
Q29790
resolver
uniprot_sec
Q29792
resolver
uniprot_sec
Q29800
resolver
uniprot_sec
Q29806
resolver
uniprot_sec
Q29833
resolver
uniprot_sec
Q29874
resolver
uniprot_sec
Q29875
resolver
uniprot_sec
Q29886
resolver
uniprot_sec
Q29968
resolver
uniprot_sec
Q29974
resolver
uniprot_sec
Q29975
resolver
uniprot_sec
Q2A120
resolver
uniprot_sec
Q2HZE5
resolver
uniprot_sec
Q2L9H4
resolver
uniprot_sec
Q2LE76
resolver
uniprot_sec
Q2MF40
resolver
uniprot_sec
Q2MJA6
resolver
uniprot_sec
Q2MZ92
resolver
uniprot_sec
Q2VQU1
resolver
uniprot_sec
Q2YHQ2
resolver
uniprot_sec
Q30006
resolver
uniprot_sec
Q30108
resolver
uniprot_sec
Q30112
resolver
uniprot_sec
Q30115
resolver
uniprot_sec
Q30116
resolver
uniprot_sec
Q30117
resolver
uniprot_sec
Q30120
resolver
uniprot_sec
Q30134
resolver
uniprot_sec
Q30142
resolver
uniprot_sec
Q30145
resolver
uniprot_sec
Q30149
resolver
uniprot_sec
Q30159
resolver
uniprot_sec
Q30166
resolver
uniprot_sec
Q30167
resolver
uniprot_sec
Q30200
resolver
uniprot_sec
Q307W5
resolver
uniprot_sec
Q31636
resolver
uniprot_sec
Q32MY7
resolver
uniprot_sec
Q3HUP9
resolver
uniprot_sec
Q3KTM1
resolver
uniprot_sec
Q3LA84
resolver
uniprot_sec
Q3LA87
resolver
uniprot_sec
Q3LA88
resolver
uniprot_sec
Q3LA89
resolver
uniprot_sec
Q3LA90
resolver
uniprot_sec
Q3LA91
resolver
uniprot_sec
Q3LA92
resolver
uniprot_sec
Q3LA93
resolver
uniprot_sec
Q3LA94
resolver
uniprot_sec
Q3LA95
resolver
uniprot_sec
Q3LA96
resolver
uniprot_sec
Q3LA97
resolver
uniprot_sec
Q3LA98
resolver
uniprot_sec
Q3LA99
resolver
uniprot_sec
Q3LAA0
resolver
uniprot_sec
Q3LAA1
resolver
uniprot_sec
Q3LAA2
resolver
uniprot_sec
Q3MQ60
resolver
uniprot_sec
Q3T919
resolver
uniprot_sec
Q4PRC3
resolver
uniprot_sec
Q4PRC5
resolver
uniprot_sec
Q4VZY7
resolver
uniprot_sec
Q53IG1
resolver
uniprot_sec
Q56FN9
resolver
uniprot_sec
Q56FP1
resolver
uniprot_sec
Q56FP2
resolver
uniprot_sec
Q56FP3
resolver
uniprot_sec
Q58F52
resolver
uniprot_sec
Q5BM92
resolver
uniprot_sec
Q5EER6
resolver
uniprot_sec
Q5K3W2
resolver
uniprot_sec
Q5NDB9
resolver
uniprot_sec
Q5U9W6
resolver
uniprot_sec
Q5UBA2
resolver
uniprot_sec
Q5UT58
resolver
uniprot_sec
Q5W3L4
resolver
uniprot_sec
Q5Y7A7
resolver
uniprot_sec
Q5Y7B0
resolver
uniprot_sec
Q5Y7B9
resolver
uniprot_sec
Q5Y7E9
resolver
uniprot_sec
Q5Y7G0
resolver
uniprot_sec
Q683P7
resolver
uniprot_sec
Q6REE2
resolver
uniprot_sec
Q6T865
resolver
uniprot_sec
Q6U387
resolver
uniprot_sec
Q701T1
resolver
uniprot_sec
Q70GL2
resolver
uniprot_sec
Q70Q85
resolver
uniprot_sec
Q768U2
resolver
uniprot_sec
Q768U4
resolver
uniprot_sec
Q7M2H4
resolver
uniprot_sec
Q7YNY9
resolver
uniprot_sec
Q7YP03
resolver
uniprot_sec
Q7YP04
resolver
uniprot_sec
Q7YQ26
resolver
uniprot_sec
Q7YQA3
resolver
uniprot_sec
Q7YQA5
resolver
uniprot_sec
Q860D8
resolver
uniprot_sec
Q860D9
resolver
uniprot_sec
Q860E5
resolver
uniprot_sec
Q860H8
resolver
uniprot_sec
Q860S0
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Q860Z3
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Q861G6
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Q95461
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Q95HK1
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Q95HL0
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Q95HL1
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Q9Y4H7
resolver
amino_acid_sequence
MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYFYNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS
uniprot
proteins
disease_involvement
DISEASE: Note=In populations of European descent, allele DRB1*01:03 is associated with increased susceptibility to Crohn disease and colonic ulcerative colitis. Decreased heterozygosity in individuals with colonic ulcerative colitis suggests that it acts as a recessive risk allele. {ECO:0000269|PubMed:25559196}.; DISEASE: Sarcoidosis 1 (SS1) [MIM:181000]: An idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. Alleles DRB1*04:02, DRB1*11:01 and DRB1*12:01 are associated with sarcoidosis. Allele DRB1*04:02 is significantly associated with specific sarcodosis phenotypes such as eye, parotid and salivary gland involvement. {ECO:0000269|PubMed:14508706}.; DISEASE: Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. In populations of European descent, allele DRB1*15:01 has the strongest association with multiple sclerosis among all HLA class II alleles. Additional risk is associated with the strongly linked alleles DRB1*03:01 and DQB1*02:01 as well as with allele DRB1*13:03 (PubMed:21833088). It is postulated that bacterial or viral infection triggers the autoimmune MS. Microbial peptides having low affinity crossreactivity to MBP autoantigen, may stimulate autoreactive T cells via molecular mimicry and initiate the autoimmune inflammation (PubMed:19303388). {ECO:0000269|PubMed:19303388, ECO:0000269|PubMed:21833088}.; DISEASE: Note=Allele DRB1*15:01 is associated with increased susceptibility to Goodpasture syndrome. Can present a self-peptide derived from COL4A3 (GWISLWKGFSF) on TCR (TRAV19 biased) in pathogenic CD4-positive T-helper 1 and T-helper 17 cells, triggering autoimmune inflammation. {ECO:0000269|PubMed:28467828}.; DISEASE: Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269|PubMed:22286218}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. Alleles DRB1*04:01; DRB1*04:04; DRB1*04:05; DRB1*04:08; DRB1*10:01; DRB1*01:01 and DRB1*01:02 are associated with increased susceptibility to rheumatoid arthritis, where affected individuals have antibodies to cyclic citrullinated peptide (anti-CCP-positive rheumatoid arthritis). Variations at position 40 in the peptide-binding cleft of these alleles explain most of the association to rheumatoid arthritis risk. {ECO:0000269|PubMed:22286218}.
uniprot
proteins
function
FUNCTION: A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:15265931, PubMed:16148104, PubMed:22327072, PubMed:27591323, PubMed:29884618, PubMed:31495665, PubMed:8642306). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (PubMed:17182262, PubMed:23783831). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides (PubMed:25413013). The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed:8145819). {ECO:0000269|PubMed:15265931, ECO:0000269|PubMed:17182262, ECO:0000269|PubMed:22327072, ECO:0000269|PubMed:23783831, ECO:0000269|PubMed:25413013, ECO:0000269|PubMed:27591323, ECO:0000269|PubMed:29884618, ECO:0000269|PubMed:31495665, ECO:0000269|PubMed:8145819, ECO:0000269|PubMed:8642306}.; FUNCTION: Allele DRB1*01:01: Displays an immunodominant epitope derived from Bacillus anthracis pagA/protective antigen, PA (KLPLYISNPNYKVNVYAVT), to both naive and PA-specific memory CD4-positive T cells (PubMed:22327072). Presents immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load (PubMed:29884618). May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (PRFSLPFLSIASAYYMFYDG) and VP2 (PHQFINLRSNNSATLIVPYV), contributing to viral clearance (PubMed:27591323). Displays commonly recognized peptides derived from IAV external protein HA (PKYVKQNTLKLAT and SNGNFIAPEYAYKIVK) and from internal proteins M, NP and PB1, with M-derived epitope (GLIYNRMGAVTTEV) being the most immunogenic (PubMed:25413013, PubMed:32668259, PubMed:8145819, PubMed:9075930). Presents a self-peptide derived from COL4A3 (GWISLWKGFSF) to TCR (TRAV14 biased) on CD4-positive, FOXP3-positive regulatory T cells and mediates immune tolerance to self (PubMed:28467828). May present peptides derived from oncofetal trophoblast glycoprotein TPBG 5T4, known to be recognized by both T-helper 1 and regulatory T cells (PubMed:31619516). Displays with low affinity a self-peptide derived from MBP (VHFFKNIVTPRTP) (PubMed:9075930). {ECO:0000269|PubMed:22327072, ECO:0000269|PubMed:25413013, ECO:0000269|PubMed:27591323, ECO:0000269|PubMed:28467828, ECO:0000269|PubMed:29884618, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:32668259, ECO:0000269|PubMed:8145819, ECO:0000269|PubMed:9075930}.; FUNCTION: Allele DRB1*03:01: May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (NEKQPSDDNWLNFDGTLLGN), contributing to viral clearance (PubMed:27591323). Displays self-peptides derived from retinal SAG (NRERRGIALDGKIKHE) and thyroid TG (LSSVVVDPSIRHFDV) (PubMed:25413013). Presents viral epitopes derived from HHV-6B gH/U48 and U85 antigens to polyfunctional CD4-positive T cells with cytotoxic activity implicated in control of HHV-6B infection (PubMed:31020640). Presents several immunogenic epitopes derived from C.tetani neurotoxin tetX, playing a role in immune recognition and long-term protection (PubMed:19830726). {ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:25413013, ECO:0000269|PubMed:27591323, ECO:0000269|PubMed:31020640}.; FUNCTION: Allele DRB1*04:01: Presents an immunodominant bacterial epitope derived from M.tuberculosis esxB/culture filtrate antigen CFP-10 (EISTNIRQAGVQYSR), eliciting CD4-positive T cell effector functions such as IFNG production and cytotoxic activity (PubMed:15265931). May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (NEKQPSDDNWLNFDGTLLGN), contributing to viral clearance (PubMed:27591323). Presents tumor epitopes derived from melanoma-associated TYR antigen (QNILLSNAPLGPQFP and DYSYLQDSDPDSFQD), triggering CD4-positive T cell effector functions such as GMCSF production (PubMed:8642306). Displays preferentially citrullinated self-peptides derived from VIM (GVYATR/citSSAVR and SAVRAR/citSSVPGVR) and ACAN (VVLLVATEGR/ CitVRVNSAYQDK) (PubMed:24190431). Displays self-peptides derived from COL2A1 (PubMed:9354468). {ECO:0000269|PubMed:15265931, ECO:0000269|PubMed:24190431, ECO:0000269|PubMed:27591323, ECO:0000269|PubMed:8642306, ECO:0000269|PubMed:9354468}.; FUNCTION: Allele DRB1*04:02: Displays native or citrullinated self-peptides derived from VIM. {ECO:0000269|PubMed:24190431}.; FUNCTION: Allele DRB1*04:04: May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (HIVMQYMYVPPGAPIPTTRN) and VP2 (RGDSTITSQDVANAVVGYGV), contributing to viral clearance (PubMed:27591323). Displays preferentially citrullinated self-peptides derived from VIM (SAVRAR/citSSVPGVR) (PubMed:24190431). {ECO:0000269|PubMed:24190431, ECO:0000269|PubMed:27591323}.; FUNCTION: Allele DRB1*04:05: May present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies. {ECO:0000269|PubMed:19120973}.; FUNCTION: Allele DRB1*05:01: Presents an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load. {ECO:0000269|PubMed:29884618}.; FUNCTION: Allele DRB1*07:01: Upon EBV infection, presents latent antigen EBNA2 peptide (PRSPTVFYNIPPMPLPPSQL) to CD4-positive T cells, driving oligoclonal expansion and selection of a dominant virus-specific memory T cell subset with cytotoxic potential to directly eliminate virus-infected B cells (PubMed:31308093). May present to T-helper 1 cells several HRV-16 epitopes derived from capsid proteins VP1 (PRFSLPFLSIASAYYMFYDG) and VP2 (VPYVNAVPMDSMVRHNNWSL), contributing to viral clearance (PubMed:27591323). In the context of tumor immunesurveillance, may present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (MTEYKLVVVGAVGVGKSALTIQLI), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies (PubMed:22929521). In metastatic epithelial tumors, presents to intratumoral CD4-positive T cells a KRAS neoantigen (MTEYKLVVVGAVGVGKSALTIQLI) carrying G12V hotspot driver mutation and may mediate tumor regression (PubMed:30282837). {ECO:0000269|PubMed:22929521, ECO:0000269|PubMed:27591323, ECO:0000269|PubMed:30282837, ECO:0000269|PubMed:31308093}.; FUNCTION: Allele DRB1*11:01: Displays an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load (PubMed:29884618). May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (SDRIIQITRGDSTITSQDVA), contributing to viral clearance (PubMed:27591323). Presents several immunogenic epitopes derived from C.tetani neurotoxin tetX, playing a role in immune recognition and longterm protection (PubMed:19830726). In the context of tumor immunesurveillance, may present tumor-derived neoantigens to CD4-positive T cells and trigger anti-tumor helper functions (PubMed:31495665). {ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:27591323, ECO:0000269|PubMed:29884618, ECO:0000269|PubMed:31495665}.; FUNCTION: Allele DRB1*13:01: Presents viral epitopes derived from HHV-6B antigens to polyfunctional CD4-positive T cells implicated in control of HHV-6B infection. {ECO:0000269|PubMed:31020640}.; FUNCTION: Allele DRB1*15:01: May present to T-helper 1 cells an HRV-16 epitope derived from capsid protein VP2 (SNNSATLIVPYVNAVPMDSM), contributing to viral clearance (PubMed:27591323). Displays a self-peptide derived from MBP (ENPVVHFFKNIVTPR) (PubMed:25413013, PubMed:9782128). May present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies. {ECO:0000269|PubMed:19120973, ECO:0000269|PubMed:27591323, ECO:0000269|PubMed:9782128}.; FUNCTION: Allele DRB1*15:02: Displays an immunodominant HIV-1 gag peptide (FRDYVDRFYKTLRAEQASQE) on infected dendritic cells for recognition by TRAV24-TRBV2 TCR on CD4-positive T cells and controls viral load (PubMed:29884618). May present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies (PubMed:19120973). {ECO:0000269|PubMed:19120973, ECO:0000269|PubMed:29884618}.; FUNCTION: (Microbial infection) Acts as a receptor for Epstein-Barr virus on lymphocytes. {ECO:0000269|PubMed:11864610, ECO:0000269|PubMed:9151859}.
uniprot
proteins
mass_dalton
29966
uniprot
proteins
mutagenesis
MUTAGEN 166; /note="E->A: Decreases the interaction with CD4; when associated with A-172."; /evidence="ECO:0000269|PubMed:27114505"; MUTAGEN 172; /note="V->A: Decreases the interaction with CD4; when associated with A-166."; /evidence="ECO:0000269|PubMed:27114505"; MUTAGEN 177; /note="I->R: Decreases the interaction with CD4."; /evidence="ECO:0000269|PubMed:27114505"; MUTAGEN 181; /note="D->N: Reduces the interaction with HLA-DM complex that results in impaired dissociation of CLIP from MHCII."; /evidence="ECO:0000269|PubMed:11070170, ECO:0000269|PubMed:23260142"; MUTAGEN 187; /note="L->R: Decreases the interaction with CD4."; /evidence="ECO:0000269|PubMed:27114505"; MUTAGEN 213; /note="L->H: Reduces the interaction with HLA-DM complex that results in impaired dissociation of CLIP from MHCII."; /evidence="ECO:0000269|PubMed:11070170, ECO:0000269|PubMed:23260142"; MUTAGEN 216; /note="E->K: Reduces the interaction with HLA-DM complex that results in impaired dissociation of CLIP from MHCII."; /evidence="ECO:0000269|PubMed:11070170, ECO:0000269|PubMed:23260142"; MUTAGEN 254; /note="K->A: Impairs MARCHF1-dependent down-regulation through ubiquitination."; /evidence="ECO:0000269|PubMed:18305173
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MARCHF1 and MARCHF8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHCII. {ECO:0000305|PubMed:18305173}.
uniprot
proteins
pubmed
11070170
uniprot
proteins
pubmed
11432818
uniprot
proteins
pubmed
11864610
uniprot
proteins
pubmed
11972886
uniprot
proteins
pubmed
12028552
uniprot
proteins
pubmed
12358860
uniprot
proteins
pubmed
12652907
uniprot
proteins
pubmed
14508706
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15265931
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15896200
uniprot
proteins
pubmed
16140993
uniprot
proteins
pubmed
16148104
uniprot
proteins
pubmed
17174751
uniprot
proteins
pubmed
17182262
uniprot
proteins
pubmed
17345114
uniprot
proteins
pubmed
18305173
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19120973
uniprot
proteins
pubmed
19303388
uniprot
proteins
pubmed
19706888
uniprot
proteins
pubmed
19830726
uniprot
proteins
pubmed
20356336
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proteins
pubmed
21388356
uniprot
proteins
pubmed
21833088
uniprot
proteins
pubmed
21900604
uniprot
proteins
pubmed
2210803
uniprot
proteins
pubmed
22286218
uniprot
proteins
pubmed
22327072
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proteins
pubmed
22929521
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proteins
pubmed
23260142
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proteins
pubmed
23510415
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proteins
pubmed
23783831
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proteins
pubmed
24190431
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proteins
pubmed
2497068
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proteins
pubmed
25413013
uniprot
proteins
pubmed
25559196
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proteins
pubmed
26396036
uniprot
proteins
pubmed
2658055
uniprot
proteins
pubmed
27114505
uniprot
proteins
pubmed
27591323
uniprot
proteins
pubmed
28467828
uniprot
proteins
pubmed
2885840
uniprot
proteins
pubmed
29317506
uniprot
proteins
pubmed
29884618
uniprot
proteins
pubmed
2998758
uniprot
proteins
pubmed
30282837
uniprot
proteins
pubmed
30337930
uniprot
proteins
pubmed
31020640
uniprot
proteins
pubmed
3110774
uniprot
proteins
pubmed
3129499
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proteins
pubmed
31308093
uniprot
proteins
pubmed
31495665
uniprot
proteins
pubmed
31619516
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proteins
pubmed
3259543
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proteins
pubmed
32668259
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proteins
pubmed
3456344
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proteins
pubmed
3571980
uniprot
proteins
pubmed
3875800
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proteins
pubmed
41882355
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proteins
pubmed
6589154
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proteins
pubmed
6600932
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proteins
pubmed
6947956
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proteins
pubmed
7477400
uniprot
proteins
pubmed
7479981
uniprot
proteins
pubmed
8145819
uniprot
proteins
pubmed
8152483
uniprot
proteins
pubmed
8642306
uniprot
proteins
pubmed
9075930
uniprot
proteins
pubmed
9151859
uniprot
proteins
pubmed
9354468
uniprot
proteins
pubmed
9777332
uniprot
proteins
pubmed
9782128
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:29884618}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:9075930}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:9075930}; Single-pass type I membrane protein {ECO:0000255}. Autolysosome membrane {ECO:0000269|PubMed:17182262}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation (PubMed:18305173). Component of immunological synapses at the interface between T cell and APC (PubMed:29884618). {ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:29884618}.
uniprot
proteins
transmembrane_region
TRANSMEM 228..248; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins