Commd5
entrez
66398
canonical
uniprot
Q8R395
canonical
ensembl
ENSMUSG00000055041
resolver
ensp
ENSMUSP00000069159
resolver
ensp
ENSMUSP00000105416
resolver
enst
ENSMUST00000068407
resolver
enst
ENSMUST00000109793
resolver
genesymbol
Commd5
resolver
uniprot
A0A0R4J0U7
resolver
uniprot
Q9D6R8
resolver
uniprot_entry
A0A0R4J0U7_MOUSE
resolver
uniprot_entry
COMD5_MOUSE
resolver
uniprot_sec
Q9D6R8
resolver
amino_acid_sequence
MSALGAPAPYLHHPTDSHSGRVSFLGSQPSAEVTAVAQLLKDLDRSTFRKLLKLVVGALHGKDCREAVQHLGASANLSEERLAVLLAGTHTLLQQALRLPPASLKPDAFQDELQELGIPQDMIGDLASLAFGSQRPLLDSVAQQQGSSLPRVSNFRWRVDVAISTSAQSRSLQPSVLMQLKLTDGSAHRFEVPIAKFQELRYSVALVLKEMAELERKCERKLQD
uniprot
proteins
function
FUNCTION: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). Negatively regulates cell proliferation (By similarity). Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway (By similarity). Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (By similarity). {ECO:0000250|UniProtKB:Q9ERR2, ECO:0000250|UniProtKB:Q9GZQ3}.
uniprot
proteins
mass_dalton
24493
uniprot
proteins
protein_family
COMM domain-containing protein 5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9GZQ3}. Cytoplasm {ECO:0000250|UniProtKB:Q9GZQ3}.
uniprot
proteins