TCP1
entrez
6950
canonical
uniprot
P17987
canonical
ensembl
ENSG00000120438
resolver
ensp
ENSP00000317334
resolver
ensp
ENSP00000376008
resolver
enst
ENST00000321394
resolver
enst
ENST00000392168
resolver
genesymbol
TCP1
resolver
genesymbol_syn
CCT1
resolver
genesymbol_syn
CCTA
resolver
hgnc
HGNC:11655
resolver
uniprot
E1P5B2
resolver
uniprot
E7EQR6
resolver
uniprot
Q15556
resolver
uniprot
Q5TCM3
resolver
uniprot_entry
E7EQR6_HUMAN
resolver
uniprot_entry
TCPA_HUMAN
resolver
uniprot_sec
E1P5B2
resolver
uniprot_sec
Q15556
resolver
uniprot_sec
Q5TCM3
resolver
amino_acid_sequence
MEGPLSVFGDRSTGETIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRYINENLIVNTDELGRDCLINAAKTSMSSKIIGINGDFFANMVVDAVLAIKYTDIRGQPRYPVNSVNILKAHGRSQMESMLISGYALNCVVGSQGMPKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKASGATILSTLANLEGEETFEAAMLGQAEEVVQERICDDELILIKNTKARTSASIILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLSNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIKLHPESKDDKHGSYEDAVHSGALND
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder with polymicrogyria and seizures (IDDPMGS) [MIM:621021]: An autosomal dominant neurologic disorder characterized by a broad phenotypic spectrum. Main clinical features are developmental delay of varying severity, intellectual disability, seizures, and polymicrogyria. Additional variable features are non-specific pyramidal or cerebellar signs, and visual impairment. {ECO:0000269|PubMed:39480921}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
function
FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
uniprot
proteins
mass_dalton
60344
uniprot
proteins
protein_family
TCP-1 chaperonin family
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14532270
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1630492
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20080638
uniprot
proteins
pubmed
21098288
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2377466
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25467444
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
33144677
uniprot
proteins
pubmed
35449234
uniprot
proteins
pubmed
36493755
uniprot
proteins
pubmed
3653076
uniprot
proteins
pubmed
37193829
uniprot
proteins
pubmed
39480921
uniprot
proteins
sequence_length
556
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:1630492}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20080638}.
uniprot
proteins