Syt12
entrez
191595
canonical
uniprot
P97610
canonical
ensembl
ENSRNOG00000019306
resolver
ensembl
ENSRNOG00055018999
resolver
ensembl
ENSRNOG00060026807
resolver
ensembl
ENSRNOG00065032488
resolver
ensp
ENSRNOP00000026153
resolver
ensp
ENSRNOP00055026212
resolver
ensp
ENSRNOP00060038595
resolver
ensp
ENSRNOP00065046035
resolver
enst
ENSRNOT00000026152
resolver
enst
ENSRNOT00055032390
resolver
enst
ENSRNOT00060046435
resolver
enst
ENSRNOT00065055899
resolver
genesymbol
Syt12
resolver
genesymbol_syn
Srg1
resolver
genesymbol_syn
Sytr1
resolver
uniprot_entry
SYT12_RAT
resolver
amino_acid_sequence
MAVDVTEYHLSVIKSPPGWEVGVYAAGALALLGIAAVSLWKLWTSGSFPSPSPFPNYDYRYLQQKYGEAYVEAKLKRVPPWNAQRTTTRGPPSRKGSLSIEDTFESISELGPLELMGRELDLAPYGTLRKSQSADSLNSISSVSNTFGQDFTLGQVEVSMDYDGASHTLHVAVLQGKDLLEREEATFESCFMRVSLLPDEQIVGISRIQRNAYSIFFDEKFSVPLDPTALEEKSLRFSVFGIDEDERNVSTGVVELKLSVLDLPLQPFSGWLYLQDQNKAADAVGEILLSLSYLPTAERLTVVVVKAKNLIWTNDKTTADPFVKVYLLQDGRKMSKKKTAVKRDDPNPVFNEAMIFSVPAIVLQDLSLRVTVAESSSDGRGDNVGHVIIGPGASGMGTTHWNQMLATLRRPVSMWHPVRRN
uniprot
proteins
function
FUNCTION: Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release (PubMed:17190793). Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids (PubMed:17190793). Essential for mossy-fiber long-term potentiation in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q920N7, ECO:0000269|PubMed:17190793}.
uniprot
proteins
mass_dalton
46608
uniprot
proteins
mutagenesis
MUTAGEN 87; /note="T->A: No effect on phosphorylation by PKA."; /evidence="ECO:0000269|PubMed:17190793"; MUTAGEN 97; /note="S->A: Loss of phosphorylation by PKA. No effect on localization to synapse. Inhibits the spontaneous release of neurotransmitters."; /evidence="ECO:0000269|PubMed:17190793
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-97 is required for mossy-fiber long-term potentiation. {ECO:0000250|UniProtKB:Q920N7}.
uniprot
proteins
protein_family
Synaptotagmin family
uniprot
proteins
pubmed
17190793
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8987811
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:17190793}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins