Grpr
entrez
24938
canonical
uniprot
P52500
canonical
ensembl
ENSRNOG00000004124
resolver
ensembl
ENSRNOG00055027578
resolver
ensembl
ENSRNOG00060018204
resolver
ensembl
ENSRNOG00065014035
resolver
ensp
ENSRNOP00000005559
resolver
ensp
ENSRNOP00055039301
resolver
ensp
ENSRNOP00060025332
resolver
ensp
ENSRNOP00065018054
resolver
enst
ENSRNOT00000005559
resolver
enst
ENSRNOT00055047757
resolver
enst
ENSRNOT00060031235
resolver
enst
ENSRNOT00065023178
resolver
genesymbol
Grpr
resolver
uniprot
G3V6I7
resolver
uniprot_entry
GRPR_RAT
resolver
uniprot_sec
G3V6I7
resolver
amino_acid_sequence
MDPNNCSHLNLEVDPFLSCNNTFNQTLNPPKMDNWFHPGIIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYIIPLSIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFITSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPSLLNRSHSTGRSTTCMTSFKSTNPSATFSLINGNICHEGYV
uniprot
proteins
function
FUNCTION: Receptor for gastrin-releasing peptide (GRP) (PubMed:8391296). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (By similarity). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425). {ECO:0000250|UniProtKB:P21729, ECO:0000269|PubMed:26855425, ECO:0000269|PubMed:8391296}.
uniprot
proteins
mass_dalton
43236
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
26855425
uniprot
proteins
pubmed
33059246
uniprot
proteins
pubmed
8391296
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8391296}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..63; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 78..97; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 116..137; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 154..175; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 210..235; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 266..286; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 300..326; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins