Dyrk1a
entrez
13548
canonical
uniprot
Q61214
canonical
ensembl
ENSMUSG00000022897
resolver
ensp
ENSMUSP00000023614
resolver
ensp
ENSMUSP00000112853
resolver
ensp
ENSMUSP00000113660
resolver
ensp
ENSMUSP00000322525
resolver
ensp
ENSMUSP00000322529
resolver
ensp
ENSMUSP00000322533
resolver
enst
ENSMUST00000023614
resolver
enst
ENSMUST00000119878
resolver
enst
ENSMUST00000122284
resolver
genesymbol
Dyrk1a
resolver
genesymbol_syn
Dyrk
resolver
uniprot
A1L341
resolver
uniprot
A9C475
resolver
uniprot
F6U6X3
resolver
uniprot
Q8C774
resolver
uniprot_entry
A1L341_MOUSE
resolver
uniprot_entry
DYR1A_MOUSE
resolver
uniprot_entry
F6U6X3_MOUSE
resolver
uniprot_entry
Q8C774_MOUSE
resolver
uniprot_sec
A9C475
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by RANBP9. {ECO:0000250|UniProtKB:Q13627}.
uniprot
proteins
amino_acid_sequence
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAAQMPHSHQYSDRRQPSISDQQVSALPYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFAAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLAMRQGADREESPMTGVCVQQSPVASS
uniprot
proteins
ec_number
2.7.11.23
uniprot
proteins
ec_number
2.7.12.1
uniprot
proteins
function
FUNCTION: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:18938227, PubMed:20123978). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (By similarity). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (By similarity). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (By similarity). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (By similarity). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (By similarity). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (PubMed:20167603). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (PubMed:20167603). This in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (PubMed:18938227). {ECO:0000250|UniProtKB:Q13627, ECO:0000250|UniProtKB:Q63470, ECO:0000269|PubMed:18938227, ECO:0000269|PubMed:20123978, ECO:0000269|PubMed:20167603}.
uniprot
proteins
mass_dalton
85494
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro) (By similarity). {ECO:0000250|UniProtKB:Q13627}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MNB/DYRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15199138
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18938227
uniprot
proteins
pubmed
20123978
uniprot
proteins
pubmed
20167603
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22998443
uniprot
proteins
pubmed
8975710
uniprot
proteins
pubmed
9070862
uniprot
proteins
sequence_length
763
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:9070862}.
uniprot
proteins