KRT17
entrez
3872
canonical
uniprot
Q04695
canonical
ensembl
ENSG00000128422
resolver
ensp
ENSP00000308452
resolver
enst
ENST00000311208
resolver
genesymbol
KRT17
resolver
hgnc
HGNC:6427
resolver
uniprot
A5Z1M9
resolver
uniprot
A5Z1N0
resolver
uniprot
A5Z1N1
resolver
uniprot
A5Z1N2
resolver
uniprot
A6NDV6
resolver
uniprot
A6NKQ2
resolver
uniprot
Q14666
resolver
uniprot
Q6IP98
resolver
uniprot
Q8N1P6
resolver
uniprot_entry
K1C17_HUMAN
resolver
uniprot_entry
Q14666_HUMAN
resolver
uniprot_sec
A5Z1M9
resolver
uniprot_sec
A5Z1N0
resolver
uniprot_sec
A5Z1N1
resolver
uniprot_sec
A5Z1N2
resolver
uniprot_sec
A6NDV6
resolver
uniprot_sec
A6NKQ2
resolver
uniprot_sec
Q6IP98
resolver
uniprot_sec
Q8N1P6
resolver
amino_acid_sequence
MTTSIRQFTSSSSIKGSSGLGGGSSRTSCRLSGGLGAGSCRLGSAGGLGSTLGGSSYSSCYSFGSGGGYGSSFGGVDGLLAGGEKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQRQAPGPARDYSQYYRTIEELQNKILTATVDNANILLQIDNARLAADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVGGEINVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGNLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKKEPVTTRQVRTIVEEVQDGKVISSREQVHQTTR
uniprot
proteins
disease_involvement
DISEASE: Pachyonychia congenita 2 (PC2) [MIM:167210]: An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth. {ECO:0000269|PubMed:10571744, ECO:0000269|PubMed:11348474, ECO:0000269|PubMed:11874497, ECO:0000269|PubMed:11886499, ECO:0000269|PubMed:15102078, ECO:0000269|PubMed:15795125, ECO:0000269|PubMed:16250206, ECO:0000269|PubMed:16620218, ECO:0000269|PubMed:16625196, ECO:0000269|PubMed:17719747, ECO:0000269|PubMed:18547302, ECO:0000269|PubMed:19470054, ECO:0000269|PubMed:21326300, ECO:0000269|PubMed:23278621, ECO:0000269|PubMed:23855588, ECO:0000269|PubMed:7539673, ECO:0000269|PubMed:9008238, ECO:0000269|PubMed:9767294}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Steatocystoma multiplex (SM) [MIM:184500]: Disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs. {ECO:0000269|PubMed:16620218, ECO:0000269|PubMed:9008238, ECO:0000269|PubMed:9767294}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.; DISEASE: Note=Defects in KRT17 may be the cause of a keratinization disorder with associated thrombocytopenia characterized by generalized harlequin ichthyosis that progress into palmoplantar keratoderma. {ECO:0000269|PubMed:34686882}.
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in epithelial keratinocytes. Forms heteropolymers with type II keratins KRT6A and KRT6B, assembling into keratin filament networks that contribute to the structural integrity and specialized differentiation of various epithelial appendages, including nail and hair follicle (PubMed:10844551, PubMed:11886499, PubMed:16620218, PubMed:17719747, PubMed:7539673). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF in the specific context of hair cycling (By similarity). Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair (By similarity). Promotes epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation (PubMed:15795121, PubMed:16713453). {ECO:0000250|UniProtKB:Q9QWL7, ECO:0000269|PubMed:10844551, ECO:0000269|PubMed:11886499, ECO:0000269|PubMed:15795121, ECO:0000269|PubMed:16620218, ECO:0000269|PubMed:16713453, ECO:0000269|PubMed:17719747, ECO:0000269|PubMed:7539673}.
uniprot
proteins
mass_dalton
48106
uniprot
proteins
mutagenesis
MUTAGEN 103; /note="R->A: Down-regulates both proliferation of psoriatic T-cells and IFN-gamma production; suppresses keratinocyte growth when part of the altered peptide epitope S1."; /evidence="ECO:0000269|PubMed:16713453"; MUTAGEN 106; /note="E->A: Down-regulates proliferation of psoriatic T-cells and IFN-gamma production when part of the altered peptide epitope S1."; /evidence="ECO:0000269|PubMed:16713453"; MUTAGEN 109; /note="N->A: No significant effect on T-cell proliferation or IFN-gamma production when part of the altered peptide epitope S1."; /evidence="ECO:0000269|PubMed:16713453"; MUTAGEN 154; /note="N->A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S2."; /evidence="ECO:0000269|PubMed:16713453"; MUTAGEN 155; /note="I->A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S2."; /evidence="ECO:0000269|PubMed:16713453"; MUTAGEN 157; /note="L->A: Down-regulates proliferation of psoriatic T-cells and IFN-gamma production when part of the altered peptide epitope S2."; /evidence="ECO:0000269|PubMed:16713453"; MUTAGEN 160; /note="D->A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S4."; /evidence="ECO:0000269|PubMed:16713453"; MUTAGEN 333; /note="N->A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S4."; /evidence="ECO:0000269|PubMed:16713453"; MUTAGEN 334; /note="R->A: No significant effect on T-cell proliferation but can induce IFN-gamma production when part of the altered peptide epitope S2."; /evidence="ECO:0000269|PubMed:16713453"; MUTAGEN 336; /note="C->A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S2."; /evidence="ECO:0000269|PubMed:16713453"; MUTAGEN 339; /note="L->A: Down-regulates both proliferation of psoriatic T-cells and IFN-gamma production; suppresses keratinocyte growth when part of the altered peptide epitope S4."; /evidence="ECO:0000269|PubMed:16713453
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization. {ECO:0000269|PubMed:22006917}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
10571744
uniprot
proteins
pubmed
10651700
uniprot
proteins
pubmed
10844551
uniprot
proteins
pubmed
11348474
uniprot
proteins
pubmed
11874497
uniprot
proteins
pubmed
11886499
uniprot
proteins
pubmed
1281771
uniprot
proteins
pubmed
1372562
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15102078
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15608502
uniprot
proteins
pubmed
15795121
uniprot
proteins
pubmed
15795125
uniprot
proteins
pubmed
16250206
uniprot
proteins
pubmed
16620218
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16713453
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17719747
uniprot
proteins
pubmed
18547302
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19470054
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21326300
uniprot
proteins
pubmed
22006917
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23278621
uniprot
proteins
pubmed
23855588
uniprot
proteins
pubmed
2481679
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
34686882
uniprot
proteins
pubmed
7539673
uniprot
proteins
pubmed
9008238
uniprot
proteins
pubmed
9767294
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QWL7}.
uniprot
proteins