Mafg
entrez
17134
canonical
uniprot
O54790
canonical
ensembl
ENSMUSG00000051510
resolver
ensp
ENSMUSP00000053899
resolver
ensp
ENSMUSP00000101786
resolver
ensp
ENSMUSP00000101787
resolver
ensp
ENSMUSP00000101788
resolver
ensp
ENSMUSP00000186678
resolver
ensp
ENSMUSP00000186679
resolver
ensp
ENSMUSP00000186686
resolver
ensp
ENSMUSP00000186687
resolver
ensp
ENSMUSP00000186688
resolver
enst
ENSMUST00000058162
resolver
enst
ENSMUST00000106180
resolver
enst
ENSMUST00000106181
resolver
enst
ENSMUST00000106182
resolver
genesymbol
Mafg
resolver
uniprot_entry
MAFG_MOUSE
resolver
amino_acid_sequence
MTTPNKGNKALKVKREPGENGTSLTDEELVTMSVRELNQHLRGLSKEEIIQLKQRRRTLKNRGYAASCRVKRVTQKEELEKQKAELQQEVEKLASENASMKLELDALRSKYEALQNFARTVARSPVAPARGPLAAGLGPLVPGKVAATSVITIVKSKTDARS
uniprot
proteins
function
FUNCTION: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:16738329, PubMed:9679061). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:16738329, PubMed:9679061). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NFE2L2. Activates globin gene expression when associated with NFE2L2 (By similarity). May be involved in signal transduction of extracellular H(+) (By similarity). {ECO:0000250|UniProtKB:O15525, ECO:0000250|UniProtKB:Q76MX4}.
uniprot
proteins
mass_dalton
17877
uniprot
proteins
post_translational_modification
PTM: Sumoylation at Lys-14 is required for active transcriptional repression. {ECO:0000269|PubMed:16738329}.; PTM: Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2. {ECO:0000250|UniProtKB:O15525}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
Maf subfamily
uniprot
proteins
pubmed
11875518
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16738329
uniprot
proteins
pubmed
31398338
uniprot
proteins
pubmed
9679061
uniprot
proteins
sequence_length
162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O15525, ECO:0000255|PROSITE-ProRule:PRU00978}.
uniprot
proteins