Abcg2
entrez
312382
canonical
uniprot
Q80W57
canonical
ensembl
ENSRNOG00000007041
resolver
ensembl
ENSRNOG00055010693
resolver
ensembl
ENSRNOG00060022927
resolver
ensembl
ENSRNOG00065011581
resolver
ensp
ENSRNOP00000009546
resolver
ensp
ENSRNOP00055014517
resolver
ensp
ENSRNOP00060032851
resolver
ensp
ENSRNOP00065014393
resolver
enst
ENSRNOT00000009546
resolver
enst
ENSRNOT00055018074
resolver
enst
ENSRNOT00060039727
resolver
enst
ENSRNOT00065018828
resolver
genesymbol
Abcg2
resolver
genesymbol_syn
Bcrp1
resolver
uniprot
Q80ST1
resolver
uniprot
Q80UR3
resolver
uniprot
Q80XF3
resolver
uniprot_entry
ABCG2_RAT
resolver
uniprot_sec
Q80ST1
resolver
uniprot_sec
Q80UR3
resolver
uniprot_sec
Q80XF3
resolver
amino_acid_sequence
MSSSNDHVLVPMSQRNKNGLPGMSSRGARTLAEGDVLSFHHITYRVKVKSGFLVRKTAEKEILSDINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPRGLSGDVLINGAPQPANFKCSSGYVVQDDVVMGTLTVRENLQFSAALRLPKAMKTHEKNERINTIIKELGLDKVADSKVGTQFTRGISGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGKLMFHGPAQKALEYFASAGYHCEPYNNPADFFLDVINGDSSAVMLNRGEQDHEANKTEEPSKREKPIIENLAEFYINSTIYGETKAELDQLPVAQKKKGSSAFREPVYVTSFCHQLRWIARRSFKNLLGNPQASVAQLIVTVILGLIIGALYFGLKNDPTGMQNRAGVFFFLTTNQCFTSVSAVELFVVEKKLFIHEYISGYYRVSSYFFGKLVSDLLPMRFLPSVIYTCILYFMLGLKRTVEAFFIMMFTLIMVAYTASSMALAIAAGQSVVSVATLLMTISFVFMMLFSGLLVNLRTIGPWLSWLQYFSIPRYGFTALQHNEFLGQEFCPGLNVTMNSTCVNSYTICTGNDYLINQGIDLSPWGLWRNHVALACMIIIFLTIAYLKLLFLKKYS
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
function
FUNCTION: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion (By similarity). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (By similarity). Mediates the secretion of the vitamins riboflavin and biotin into milk (By similarity). Involved in the excretion of the riboflavin-derived compound lumichrome into the intestinal lumen and in its secretion into milk (By similarity). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain. It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (By similarity). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity). In inflammatory macrophages, exports itaconate from the cytosol to the extracellular compartment and limits the activation of TFEB-dependent lysosome biogenesis involved in antibacterial innate immune response (By similarity). Operates at apical membranes of polarized cells such as hepatocytes and intestinal epithelial cells, where it may contribute to the efflux of conjugated substrates from intestine and liver into the intestinal lumen as well as their enterohepatic recycling. Can transport estrogen and androgen substrates conjugated with glucuronate or sulfate at C-3, C-16 and C-17 positions. Among androgen glucuronates, appears to selectively transport dihydrotestosterone-17-glucuronate while displaying no transporter activity toward testosterone, androsterone and etiocholanolone glucuronates (By similarity). {ECO:0000250|UniProtKB:Q7TMS5, ECO:0000250|UniProtKB:Q9UNQ0}.
uniprot
proteins
mass_dalton
72961
uniprot
proteins
post_translational_modification
PTM: N-glycosylated in brain capillary, kidney and small intestine but not in heart. {ECO:0000269|PubMed:15255930}.; PTM: N-glycosylated. Glycosylation-deficient ABCG2 is normally expressed and functional. {ECO:0000250|UniProtKB:Q9UNQ0}.; PTM: Phosphorylated. Phosphorylation may regulate the localization to the plasma membrane, the homooligomerization and therefore, the activity of the transporter. {ECO:0000250|UniProtKB:Q9UNQ0}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCG family
uniprot
proteins
protein_family
Eye pigment precursor importer (TC 3.A.1.204) subfamily
uniprot
proteins
pubmed
12819005
uniprot
proteins
pubmed
15255930
uniprot
proteins
pubmed
18451542
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
657
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15255930}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:18451542}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q9UNQ0}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 396..416; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 429..449; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 478..498; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 507..527; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 536..556; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 633..653; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins