KLHL2
entrez
11275
canonical
uniprot
O95198
canonical
ensembl
ENSG00000109466
resolver
ensp
ENSP00000226725
resolver
ensp
ENSP00000408974
resolver
ensp
ENSP00000424108
resolver
ensp
ENSP00000424198
resolver
ensp
ENSP00000437526
resolver
ensp
ENSP00000619438
resolver
enst
ENST00000421009
resolver
enst
ENST00000506761
resolver
genesymbol
KLHL2
resolver
hgnc
HGNC:6353
resolver
uniprot
A6NCM7
resolver
uniprot
B2RD18
resolver
uniprot
B4DFH7
resolver
uniprot
B4DFZ5
resolver
uniprot
E9PEX9
resolver
uniprot
F5H6M3
resolver
uniprot
F6UM33
resolver
uniprot
Q8N484
resolver
uniprot
Q8TBH5
resolver
uniprot_entry
B4DFZ5_HUMAN
resolver
uniprot_entry
E9PEX9_HUMAN
resolver
uniprot_entry
F6UM33_HUMAN
resolver
uniprot_entry
KLHL2_HUMAN
resolver
uniprot_sec
A6NCM7
resolver
uniprot_sec
B2RD18
resolver
uniprot_sec
B4DFH7
resolver
uniprot_sec
F5H6M3
resolver
uniprot_sec
Q8N484
resolver
uniprot_sec
Q8TBH5
resolver
amino_acid_sequence
METPPLPPACTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation (PubMed:23838290). The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 (PubMed:23838290). Plays a role in the reorganization of the actin cytoskeleton (PubMed:10397770). Promotes growth of cell projections in oligodendrocyte precursors (PubMed:15715669). {ECO:0000250|UniProtKB:Q8JZP3, ECO:0000269|PubMed:10397770, ECO:0000269|PubMed:15715669, ECO:0000269|PubMed:23838290}.
uniprot
proteins
mass_dalton
65975
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:23838290}.
uniprot
proteins
pubmed
10397770
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15383316
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15715669
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
23349464
uniprot
proteins
pubmed
23838290
uniprot
proteins
pubmed
24641320
uniprot
proteins
sequence_length
593
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10397770, ECO:0000269|PubMed:15715669}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q8JZP3}. Cell projection {ECO:0000269|PubMed:15715669}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:F1LZF0}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8JZP3}. Note=A proportion colocalizes with the actin cytoskeleton (PubMed:10397770). When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity). {ECO:0000250|UniProtKB:Q8JZP3, ECO:0000269|PubMed:10397770}.
uniprot
proteins