Cep85
entrez
70012
canonical
uniprot
Q8BMK0
canonical
ensembl
ENSMUSG00000037443
resolver
ensp
ENSMUSP00000039889
resolver
ensp
ENSMUSP00000224625
resolver
ensp
ENSMUSP00000224628
resolver
enst
ENSMUST00000040271
resolver
genesymbol
Cep85
resolver
genesymbol_syn
Ccdc21
resolver
uniprot
Q8BUF1
resolver
uniprot
Q8K0E6
resolver
uniprot_entry
CEP85_MOUSE
resolver
uniprot_sec
Q8BUF1
resolver
uniprot_sec
Q8K0E6
resolver
amino_acid_sequence
MAMQEKYPNDRSHATSPGSNVIQKGSSLGTEWQTPVISETFRSRFSRCSSIADSGDTAIGTSCSDIAEDFCSSSGSPSFQPIKSHITIPTAHVMPSTLGASPAKPNSAPSGPSSAKLPLSGLTEGVGMTRNGDFGAVKRSPGLARDFMYLPSAAGENGSQQSWFPAVGHEREGEMRKFDVPSMESTLNQPAMLETLYSDPHYRAHFPNPRPDTNKDVYKVLPESKKAPGSGAVFERNGPHASSSGVLPLGLQPAPGLSKSLSSQVWQPSPDPWHPGEQSCELSTCRQQLELIRLQMEQMQLQNGAMCHHPAAFAPLLPTLEPAQWLSILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSKEKMELEKKLSASEVEIQLIRESLKVTLQKHSEEGKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQTEQLKDAELKNTELQERVAELETLLEDTQATCREKEVQLESLRQREADLSSARHSFQDKQSVEEANGENLRVDMESQQKECDSLRKMVERQQLKMEQLHSQVQSQKQELAQEEGINQALREEAQRRETALQQMRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSSSSPDSAQLACELHQELASCLQDLQAVCSIVTQRAQGHNPNLSLLLGIHSTQHPGTQLDLQKPDVIRRKLEEVQQLRHDIEDLRTSLSDRYAQDMGENCATQ
uniprot
proteins
function
FUNCTION: Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility. Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity. {ECO:0000250|UniProtKB:Q6P2H3}.
uniprot
proteins
mass_dalton
85340
uniprot
proteins
protein_family
CEP85 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
761
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q6P2H3}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q6P2H3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q6P2H3}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q6P2H3}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q6P2H3}. Note=Localizes to centrosomes and nucleolus in interphase. Upon entry into mitosis, relocates from nucleolus and accumulates at spindle poles. Associated with the pericentriolar material. Localizes to centrosomes at a low level in G1 phase and a slightly increased level in S phase, with gradually elevated levels during G2 phase. The levels at centrosomes further increase at G2/M, reaching a peak at spindle poles at early mitotic stages and remain high until the end of anaphase. Localizes at the leading edge. {ECO:0000250|UniProtKB:Q6P2H3}.
uniprot
proteins