Tnfrsf10b
entrez
21933
canonical
uniprot
Q9QZM4
canonical
ensembl
ENSMUSG00000022074
resolver
ensp
ENSMUSP00000022663
resolver
enst
ENSMUST00000022663
resolver
genesymbol
Tnfrsf10b
resolver
genesymbol_syn
Dr5
resolver
genesymbol_syn
Killer
resolver
uniprot
Q6GSD9
resolver
uniprot
Q9JJL5
resolver
uniprot
Q9JJL6
resolver
uniprot_entry
TR10B_MOUSE
resolver
uniprot_sec
Q6GSD9
resolver
uniprot_sec
Q9JJL5
resolver
uniprot_sec
Q9JJL6
resolver
amino_acid_sequence
MEPPGPSTPTASAAARADHYTPGLRPLPKRRLLYSFALLLAVLQAVFVPVTANPAHNRPAGLQRPEESPSRGPCLAGQYLSEGNCKPCREGIDYTSHSNHSLDSCILCTVCKEDKVVETRCNITTNTVCRCKPGTFEDKDSPEICQSCSNCTDGEEELTSCTPRENRKCVSKTAWASWHKLGLWIGLLVPVVLLIGALLVWKTGAWRQWLLCIKRGCERDPESANSVHSSLLDRQTSSTTNDSNHNTEPGKTQKTGKKLLVPVNGNDSADDLKFIFEYCSDIVPFDSWNRLMRQLGLTDNQIQMVKAETLVTREALYQMLLKWRHQTGRSASINHLLDALEAVEERDAMEKIEDYAVKSGRFTYQNAAAQPETGPGGSQCV
uniprot
proteins
function
FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. {ECO:0000250|UniProtKB:O14763}.
uniprot
proteins
mass_dalton
42165
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Glycosylated at Arg-293 by S.typhimurium protein Ssek3. {ECO:0000269|PubMed:30902834}.
uniprot
proteins
pubmed
10383128
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
30902834
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 181..201; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins