LIM2
entrez
3982
canonical
uniprot
P55344
canonical
ensembl
ENSG00000105370
resolver
ensp
ENSP00000221973
resolver
ensp
ENSP00000472090
resolver
genesymbol
LIM2
resolver
hgnc
HGNC:6610
resolver
uniprot
Q6B083
resolver
uniprot
Q9BXD0
resolver
uniprot
Q9HAR5
resolver
uniprot_entry
LMIP_HUMAN
resolver
uniprot_sec
Q6B083
resolver
uniprot_sec
Q9BXD0
resolver
uniprot_sec
Q9HAR5
resolver
amino_acid_sequence
MYSFMGGGLFCAWVGTILLVVAMATDHWMQYRLSGSFAHQGLWRYCLGNKCYLQTDSIAYWNATRAFMILSALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTGVTVSFLGRRFGDWRFSWSYILGWVAVLMTFFAGIFYMCAYRVHECRRLSTPR
uniprot
proteins
disease_involvement
DISEASE: Cataract, multiple types 19 (CTRCT19) [MIM:615277]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. {ECO:0000269|PubMed:11917274}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.
uniprot
proteins
mass_dalton
19674
uniprot
proteins
protein_family
PMP-22/EMP/MP20 family
uniprot
proteins
pubmed
11917274
uniprot
proteins
pubmed
12107413
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2584203
uniprot
proteins
pubmed
8137630
uniprot
proteins
sequence_length
173
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 67..87; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 99..119; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins