AASDHPPT
entrez
60496
canonical
uniprot
Q9NRN7
canonical
ensembl
ENSG00000149313
resolver
ensp
ENSP00000278618
resolver
genesymbol
AASDHPPT
resolver
hgnc
HGNC:14235
resolver
uniprot
B2R6D1
resolver
uniprot
B4DDW7
resolver
uniprot
Q9C068
resolver
uniprot
Q9P0Q3
resolver
uniprot
Q9UG80
resolver
uniprot
Q9Y389
resolver
uniprot_entry
ADPPT_HUMAN
resolver
uniprot_sec
B2R6D1
resolver
uniprot_sec
B4DDW7
resolver
uniprot_sec
Q9C068
resolver
uniprot_sec
Q9P0Q3
resolver
uniprot_sec
Q9UG80
resolver
uniprot_sec
Q9Y389
resolver
amino_acid_sequence
MVFPAKRFCLVPSMEGVRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDAKAAMAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVLAKDSSNPYPNFNFNISHQGDYAVLAAEPELQVGIDIMKTSFPGRGSIPEFFHIMKRKFTNKEWETIRSFKDEWTQLDMFYRNWALKESFIKAIGVGLGFELQRLEFDLSPLNLDIGQVYKETRLFLDGEEEKEWAFEESKIDEHHFVAVALRKPDGSRHQDVPSQDDSKPTQRQFTILNFNDLMSSAVPMTPEDPSFWDCFCFTEEIPIRNGTKS
uniprot
proteins
ec_number
2.7.8.7
uniprot
proteins
function
FUNCTION: Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN. {ECO:0000269|PubMed:11286508, ECO:0000269|PubMed:12815048, ECO:0000269|PubMed:18022563, ECO:0000269|PubMed:19933275, ECO:0000269|PubMed:21238436}.
uniprot
proteins
mass_dalton
35776
uniprot
proteins
mutagenesis
MUTAGEN 47; /note="R->A: Reduces affinity for magnesium by 7-fold, and holo-[acyl-carrier-protein] synthase activity by 2-fold."; /evidence="ECO:0000269|PubMed:18022563"; MUTAGEN 86; /note="R->A: Reduces affinity for magnesium and coenzyme A, and reduces holo-[acyl-carrier-protein] synthase activity by 7-fold."; /evidence="ECO:0000269|PubMed:18022563"; MUTAGEN 111; /note="H->A: Reduces affinity for magnesium by 75-fold, and holo-[acyl-carrier-protein] synthase activity by 150-fold."; /evidence="ECO:0000269|PubMed:18022563"; MUTAGEN 112; /note="Q->E: Reduces affinity for magnesium by 200-fold and abolishes holo-[acyl-carrier-protein] synthase activity; when associated with Q-181."; /evidence="ECO:0000269|PubMed:18022563"; MUTAGEN 129; /note="D->A: Reduces affinity for magnesium by 10-fold, and holo-[acyl-carrier-protein] synthase activity by 30000-fold."; /evidence="ECO:0000269|PubMed:18022563"; MUTAGEN 181; /note="E->A: Reduces affinity for magnesium by 40-fold, and holo-[acyl-carrier-protein] synthase activity by 32000-fold."; /evidence="ECO:0000269|PubMed:18022563"; MUTAGEN 181; /note="E->Q: Reduces affinity for magnesium by 20-fold, and holo-[acyl-carrier-protein] synthase activity by 6500-fold."; /evidence="ECO:0000269|PubMed:18022563"; MUTAGEN 185; /note="K->A: Reduces holo-[acyl-carrier-protein] synthase activity by 2000-fold, with only minor change in the affinity for magnesium and coenzyme A."; /evidence="ECO:0000269|PubMed:18022563
uniprot
proteins
protein_family
AcpS family
uniprot
proteins
protein_family
P-Pant transferase superfamily
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11286508
uniprot
proteins
pubmed
12815048
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18022563
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19933275
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21238436
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12815048}.
uniprot
proteins