CD80
entrez
941
canonical
uniprot
P33681
canonical
ensembl
ENSG00000121594
resolver
ensp
ENSP00000264246
resolver
genesymbol
CD80
resolver
genesymbol_syn
CD28LG
resolver
genesymbol_syn
CD28LG1
resolver
genesymbol_syn
LAB7
resolver
hgnc
HGNC:1700
resolver
uniprot
A0N0P2
resolver
uniprot
D3DN82
resolver
uniprot
Q5DTA9
resolver
uniprot
Q5DTB0
resolver
uniprot_entry
A0N0P2_HUMAN
resolver
uniprot_entry
CD80_HUMAN
resolver
uniprot_sec
D3DN82
resolver
uniprot_sec
Q5DTA9
resolver
uniprot_sec
Q5DTB0
resolver
amino_acid_sequence
MGHTRRQGTSPSKCPYLNFFQLLVLAGLSHFCSGVIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFPDNLLPSWAITLISVNGIFVICCLTYCFAPRCRERRRNERLRRESVRPV
uniprot
proteins
function
FUNCTION: Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:38467718). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:12196291). In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines (PubMed:10438913). Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming (PubMed:10583602, PubMed:11279502). In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway (PubMed:12121659). Also acts as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses (PubMed:36727298). Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses (By similarity). {ECO:0000250|UniProtKB:Q00609, ECO:0000269|PubMed:10438913, ECO:0000269|PubMed:10583602, ECO:0000269|PubMed:11279502, ECO:0000269|PubMed:12121659, ECO:0000269|PubMed:12196291, ECO:0000269|PubMed:36727298, ECO:0000269|PubMed:38467718}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus subgroup B. {ECO:0000269|PubMed:16920215}.
uniprot
proteins
mass_dalton
33048
uniprot
proteins
mutagenesis
MUTAGEN 261; /note="C->S: Loss of costimulatory function upon T-cell activation; when associated with S-262, S-266 and S-271."; /evidence="ECO:0000269|PubMed:38467718"; MUTAGEN 262; /note="C->S: Loss of costimulatory function upon T-cell activation; when associated with S-261, S-266 and S-271."; /evidence="ECO:0000269|PubMed:38467718"; MUTAGEN 266; /note="C->S: Loss of costimulatory function upon T-cell activation; when associated with S-261, S-262 and S-271."; /evidence="ECO:0000269|PubMed:38467718"; MUTAGEN 271; /note="C->S: Loss of costimulatory function upon T-cell activation; when associated with S-261, S-262 and S-266."; /evidence="ECO:0000269|PubMed:38467718
uniprot
proteins
post_translational_modification
PTM: Palmitoylated by ZDHHC20; palmitoylation protects CD80 from ubiquitin-mediated degradation, regulating the protein stability, and ensures its accurate plasma membrane localization. {ECO:0000269|PubMed:38467718}.
uniprot
proteins
pubmed
10438913
uniprot
proteins
pubmed
10583602
uniprot
proteins
pubmed
10661405
uniprot
proteins
pubmed
11279502
uniprot
proteins
pubmed
12121659
uniprot
proteins
pubmed
12196291
uniprot
proteins
pubmed
1377173
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16920215
uniprot
proteins
pubmed
1714935
uniprot
proteins
pubmed
17953528
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2794510
uniprot
proteins
pubmed
30918073
uniprot
proteins
pubmed
36727298
uniprot
proteins
pubmed
38467718
uniprot
proteins
pubmed
7527824
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2794510, ECO:0000269|PubMed:38467718}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 243..263; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins