SLC35B4
entrez
84912
canonical
uniprot
Q969S0
canonical
ensembl
ENSG00000205060
resolver
ensp
ENSP00000367770
resolver
ensp
ENSP00000758924
resolver
genesymbol
SLC35B4
resolver
genesymbol_syn
YEA4
resolver
hgnc
HGNC:20584
resolver
uniprot
A4D1P3
resolver
uniprot
A6NNS4
resolver
uniprot
Q53GQ7
resolver
uniprot
Q8TCU7
resolver
uniprot
Q96K33
resolver
uniprot_entry
S35B4_HUMAN
resolver
uniprot_sec
A4D1P3
resolver
uniprot_sec
A6NNS4
resolver
uniprot_sec
Q53GQ7
resolver
uniprot_sec
Q8TCU7
resolver
uniprot_sec
Q96K33
resolver
amino_acid_sequence
MRPALAVGLVFAGCCSNVIFLELLARKHPGCGNIVTFAQFLFIAVEGFLFEADLGRKPPAIPIRYYAIMVTMFFTVSVVNNYALNLNIAMPLHMIFRSGSLIANMILGIIILKKRYSIFKYTSIALVSVGIFICTFMSAKQVTSQSSLSENDGFQAFVWWLLGIGALTFALLMSARMGIFQETLYKRFGKHSKEALFYNHALPLPGFVFLASDIYDHAVLFNKSELYEIPVIGVTLPIMWFYLLMNIITQYVCIRGVFILTTECASLTVTLVVTLRKFVSLIFSILYFQNPFTLWHWLGTLFVFIGTLMYTEVWNNLGTTKSEPQKDSKKN
uniprot
proteins
function
FUNCTION: Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for another nucleotide sugar. May couple UDP-alpha-D-glucuronate (UDP-GlcA) or UDP-alpha-D-xylose (UDP-Xyl) efflux to UDP-alpha-D-glucuronate (UDP-GlcA) influx into the ER lumen, which in turn stimulates glucuronidation and excretion of endobiotics and xenobiotics. {ECO:0000269|PubMed:16965264, ECO:0000305|PubMed:15911612}.; FUNCTION: [Isoform 1]: Has UDP-GlcA:UDP-GlcNAc antiporter activity. {ECO:0000269|PubMed:16965264}.; FUNCTION: [Isoform 2]: Has UDP-GlcA:UDP-GlcNAc antiporter activity. {ECO:0000269|PubMed:16965264}.
uniprot
proteins
mass_dalton
37424
uniprot
proteins
mutagenesis
MUTAGEN 329; /note="K->A: Results in loss of ER retention signal and relocalization at the Golgi apparatus."; /evidence="ECO:0000269|PubMed:30458018"; MUTAGEN 330; /note="K->A: Results in loss of ER retention signal and relocalization at the Golgi apparatus."; /evidence="ECO:0000269|PubMed:30458018
uniprot
proteins
protein_family
Nucleotide-sugar transporter family
uniprot
proteins
protein_family
SLC35B subfamily
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15911612
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16965264
uniprot
proteins
pubmed
30458018
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30458018}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 30..50; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 59..79; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 153..173; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 229..249; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 251..267; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 268..288; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 291..311; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins