CTRC
entrez
11330
canonical
uniprot
Q99895
canonical
ensembl
ENSG00000162438
resolver
ensp
ENSP00000365116
resolver
enst
ENST00000375949
resolver
genesymbol
CTRC
resolver
genesymbol_syn
CLCR
resolver
hgnc
HGNC:2523
resolver
uniprot
A8K082
resolver
uniprot
O00765
resolver
uniprot
Q9NUH5
resolver
uniprot_entry
CTRC_HUMAN
resolver
uniprot_sec
A8K082
resolver
uniprot_sec
O00765
resolver
uniprot_sec
Q9NUH5
resolver
amino_acid_sequence
MLGITVLAALLACASSCGVPSFPPNLSARVVGGEDARPHSWPWQISLQYLKNDTWRHTCGGTLIASNFVLTAAHCISNTRTYRVAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLLRNDIALIKLAEHVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQGLQPVVDHATCSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIVSFGSRRGCNTRKKPVVYTRVSAYIDWINEKMQL
uniprot
proteins
disease_involvement
DISEASE: Pancreatitis, hereditary (PCTT) [MIM:167800]: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. {ECO:0000269|PubMed:18059268, ECO:0000269|PubMed:18172691, ECO:0000269|PubMed:22580415, ECO:0000269|PubMed:22942235}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. Loss-of-function CTRC variants predispose to pancreatitis by diminishing its protective trypsin-degrading activity (PubMed:18059268). They cause loss of function by one or more of three mechanisms: reduced secretion, catalytic defect and increased degradation by trypsin (PubMed:22942235). {ECO:0000269|PubMed:18059268, ECO:0000269|PubMed:22942235}.
uniprot
proteins
ec_number
3.4.21.2
uniprot
proteins
function
FUNCTION: Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity. {ECO:0000269|PubMed:23430245}.
uniprot
proteins
mass_dalton
29484
uniprot
proteins
protein_family
Elastase subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18059268
uniprot
proteins
pubmed
18172691
uniprot
proteins
pubmed
19407484
uniprot
proteins
pubmed
22580415
uniprot
proteins
pubmed
22942235
uniprot
proteins
pubmed
23135764
uniprot
proteins
pubmed
23430245
uniprot
proteins
pubmed
8635596
uniprot
proteins
pubmed
9538241
uniprot
proteins
sequence_length
268
uniprot
proteins