KLF11
entrez
8462
canonical
uniprot
O14901
canonical
ensembl
ENSG00000172059
resolver
ensp
ENSP00000307023
resolver
ensp
ENSP00000442722
resolver
ensp
ENSP00000444690
resolver
genesymbol
KLF11
resolver
genesymbol_syn
FKLF
resolver
genesymbol_syn
TIEG2
resolver
hgnc
HGNC:11811
resolver
uniprot
B4DZE7
resolver
uniprot
B7ZAX4
resolver
uniprot
Q53QU8
resolver
uniprot
Q9EPF4
resolver
uniprot_entry
B7ZAX4_HUMAN
resolver
uniprot_entry
KLF11_HUMAN
resolver
uniprot_entry
Q53QU8_HUMAN
resolver
uniprot_sec
B4DZE7
resolver
uniprot_sec
Q9EPF4
resolver
amino_acid_sequence
MHTPDFAGPDDARAVDIMDICESILERKRHDSERSTCSILEQTDMEAVEALVCMSSWGQRSQKGDLLRIRPLTPVSDSGDVTTTVHMDAATPELPKDFHSLSTLCITPPQSPDLVEPSTRTPVSPQVTDSKACTATDVLQSSAVVARALSGGAERGLLGLEPVPSSPCRAKGTSVIRHTGESPAACFPTIQTPDCRLSDSREGEEQLLGHFETLQDTHLTDSLLSTNLVSCQPCLHKSGGLLLTDKGQQAGWPGAVQTCSPKNYENDLPRKTTPLISVSVPAPPVLCQMIPVTGQSSMLPAFLKPPPQLSVGTVRPILAQAAPAPQPVFVGPAVPQGAVMLVLPQGALPPPAPCAANVMAAGNTKLLPLAPAPVFITSSQNCVPQVDFSRRRNYVCSFPGCRKTYFKSSHLKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRTHTGEKKFVCPVCDRRFMRSDHLTKHARRHMTTKKIPGWQAEVGKLNRIASAESPGSPLVSMPASA
uniprot
proteins
disease_involvement
DISEASE: Maturity-onset diabetes of the young 7 (MODY7) [MIM:610508]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. {ECO:0000269|PubMed:15774581}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Transcription factor (PubMed:10207080, PubMed:9748269). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:10207080, PubMed:16131492, PubMed:9748269). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity). {ECO:0000250|UniProtKB:Q8K1S5, ECO:0000269|PubMed:10207080, ECO:0000269|PubMed:16131492}.
uniprot
proteins
mass_dalton
55139
uniprot
proteins
protein_family
Sp1 C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
10207080
uniprot
proteins
pubmed
11087666
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15774581
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16131492
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9748269
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9748269}.
uniprot
proteins