ABHD10
entrez
55347
canonical
uniprot
Q9NUJ1
canonical
ensembl
ENSG00000144827
resolver
ensp
ENSP00000273359
resolver
ensp
ENSP00000418973
resolver
genesymbol
ABHD10
resolver
hgnc
HGNC:25656
resolver
uniprot
B7Z6A8
resolver
uniprot
C9IZX5
resolver
uniprot
D3DN63
resolver
uniprot
Q8TCF9
resolver
uniprot_entry
ABHDA_HUMAN
resolver
uniprot_sec
B7Z6A8
resolver
uniprot_sec
C9IZX5
resolver
uniprot_sec
D3DN63
resolver
uniprot_sec
Q8TCF9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by palmostatin-B. {ECO:0000269|PubMed:31740833}.
uniprot
proteins
amino_acid_sequence
MAVARLAAVAAWVPCRSWGWAAVPFGPHRGLSVLLARIPQRAPRWLPACRQKTSLSFLNRPDLPNLAYKKLKGKSPGIIFIPGYLSYMNGTKALAIEEFCKSLGHACIRFDYSGVGSSDGNSEESTLGKWRKDVLSIIDDLADGPQILVGSSLGGWLMLHAAIARPEKVVALIGVATAADTLVTKFNQLPVELKKEVEMKGVWSMPSKYSEEGVYNVQYSFIKEAEHHCLLHSPIPVNCPIRLLHGMKDDIVPWHTSMQVADRVLSTDVDVILRKHSDHRMREKADIQLLVYTIDDLIDKLSTIVN
uniprot
proteins
ec_number
3.1.1.93
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
function
FUNCTION: Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins (PubMed:31740833). Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability (PubMed:31740833). Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate (PubMed:22294686). {ECO:0000269|PubMed:22294686, ECO:0000269|PubMed:31740833}.
uniprot
proteins
mass_dalton
33933
uniprot
proteins
mutagenesis
MUTAGEN 152; /note="S->A: Loss of palmitoyl-(protein) hydrolase activity."; /evidence="ECO:0000269|PubMed:31740833
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22294686
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
31740833
uniprot
proteins
sequence_length
306
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:31740833}.
uniprot
proteins