Mc5r
entrez
17203
canonical
uniprot
P41149
canonical
ensembl
ENSMUSG00000007480
resolver
ensp
ENSMUSP00000130497
resolver
enst
ENSMUST00000172148
resolver
genesymbol
Mc5r
resolver
uniprot
G3UWB6
resolver
uniprot
Q496T0
resolver
uniprot_entry
G3UWB6_MOUSE
resolver
uniprot_entry
MC5R_MOUSE
resolver
uniprot_entry
Q496T0_MOUSE
resolver
amino_acid_sequence
MNSSSTLTVLNLTLNASEDGILGSNVKNKSLACEEMGIAVEVFLTLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETVTIYLLNNKHLVIADTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALRYHHIMTARRSGVIIACIWTFCISCGIVFIIYYESKYVIICLISMFFTMLFFMVSLYIHMFLLARNHVKRIAASPRYNSVRQRTSMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNVYCSCFMSYFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIVCCHGFRRPCRLLGGY
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for melanocyte-stimulating hormones (alpha- beta- and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:35926007, PubMed:7739752, PubMed:8185570, PubMed:9413988). Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway (PubMed:7739752, PubMed:8185570, PubMed:9413988). Also activates ERK1/2 via a PI3K-dependent signaling mechanism (PubMed:35926007). Order of potency of natural melanocortins in receptor activation is alpha-MSH > beta-MSH > ACTH > gamma-MSH (PubMed:7739752, PubMed:8185570). Plays a key role in immune response, and is essential for temperature regulation and exocrine gland function (PubMed:35926007, PubMed:9413988). {ECO:0000269|PubMed:35926007, ECO:0000269|PubMed:7739752, ECO:0000269|PubMed:8185570, ECO:0000269|PubMed:9413988}.
uniprot
proteins
mass_dalton
36953
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
35926007
uniprot
proteins
pubmed
7739752
uniprot
proteins
pubmed
8161509
uniprot
proteins
pubmed
8185570
uniprot
proteins
pubmed
9413988
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 38..61; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 74..97; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 115..138; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 156..179; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 187..211; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 240..265; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 274..297; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins