FOSB
entrez
2354
canonical
uniprot
P53539
canonical
ensembl
ENSG00000125740
resolver
ensp
ENSP00000245919
resolver
ensp
ENSP00000407207
resolver
ensp
ENSP00000465552
resolver
genesymbol
FOSB
resolver
genesymbol_syn
G0S3
resolver
hgnc
HGNC:3797
resolver
uniprot
A8K9K5
resolver
uniprot
A8VJE1
resolver
uniprot
A8VJE6
resolver
uniprot
A8VJF0
resolver
uniprot
A8VJF3
resolver
uniprot
A8VJF7
resolver
uniprot
A8VJG1
resolver
uniprot
A8VJG5
resolver
uniprot
A8VJG9
resolver
uniprot
E7EPR6
resolver
uniprot
E9PHJ3
resolver
uniprot
K7EKC1
resolver
uniprot
K7EMJ6
resolver
uniprot
Q49AD7
resolver
uniprot_entry
FOSB_HUMAN
resolver
uniprot_sec
A8K9K5
resolver
uniprot_sec
A8VJE1
resolver
uniprot_sec
A8VJE6
resolver
uniprot_sec
A8VJF0
resolver
uniprot_sec
A8VJF3
resolver
uniprot_sec
A8VJF7
resolver
uniprot_sec
A8VJG1
resolver
uniprot_sec
A8VJG5
resolver
uniprot_sec
A8VJG9
resolver
uniprot_sec
E7EPR6
resolver
uniprot_sec
E9PHJ3
resolver
uniprot_sec
K7EKC1
resolver
uniprot_sec
K7EMJ6
resolver
uniprot_sec
Q49AD7
resolver
amino_acid_sequence
MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASLFTHSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLAL
uniprot
proteins
function
FUNCTION: Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity (PubMed:12618758, PubMed:28981703). As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (By similarity). Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Exhibits transactivation activity in vitro (By similarity). Involved in the display of nurturing behavior towards newborns (By similarity). May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (By similarity). Implicated in behavioral responses related to morphine reward and spatial memory (By similarity). {ECO:0000250|UniProtKB:P13346, ECO:0000269|PubMed:12618758, ECO:0000269|PubMed:28981703}.; FUNCTION: [Isoform 11]: Exhibits lower transactivation activity than isoform 1 in vitro (By similarity). The heterodimer with JUN does not display any transcriptional activity, and may thereby act as an transcriptional inhibitor (By similarity). May be involved in the regulation of neurogenesis in the hippocampus (By similarity). May play a role in synaptic modifications in nucleus accumbens medium spiny neurons and thereby play a role in adaptive and pathological reward-dependent learning, including maladaptive responses involved in drug addiction (By similarity). Seems to be more stably expressed with a half-life of ~9.5 hours in cell culture as compared to 1.5 hours half-life of isoform 1 (By similarity). {ECO:0000250|UniProtKB:P13346}.
uniprot
proteins
mass_dalton
35928
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:D3ZLB7}.; PTM: [Isoform 11]: Phosphorylated at Ser-27 by CSNK2A1; phosphorylation increases protein stability and transactivation potential. {ECO:0000250|UniProtKB:P13346}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
Fos subfamily
uniprot
proteins
pubmed
12618758
uniprot
proteins
pubmed
1301997
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20473292
uniprot
proteins
pubmed
28981703
uniprot
proteins
pubmed
32542236
uniprot
proteins
pubmed
8985116
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P13346}.
uniprot
proteins