P22858
uniprot
P22858
canonical
amino_acid_sequence
MLRRLVQQWSVLVFLLSYSVPSRGRSVEGLGRRLKRAVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPAPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRREQEKKKRRTRSAWPSTAASGLLEDPLPHTSRTSLEPSLRTH
uniprot
proteins
function
FUNCTION: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport (PubMed:8314082, PubMed:8895385). Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (By similarity). Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth (PubMed:20501677, PubMed:8314082, PubMed:8895385). Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs (By similarity). Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion (PubMed:17301089). BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (PubMed:17301089). {ECO:0000250|UniProtKB:P12272, ECO:0000269|PubMed:17301089, ECO:0000269|PubMed:20501677, ECO:0000269|PubMed:8314082, ECO:0000269|PubMed:8895385}.; FUNCTION: [Osteostatin]: Potent inhibitor of osteoclastic bone resorption. {ECO:0000250|UniProtKB:P12272}.
uniprot
proteins
mass_dalton
20100
uniprot
proteins
post_translational_modification
PTM: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions (By similarity). {ECO:0000250|UniProtKB:P12272}.
uniprot
proteins
protein_family
Parathyroid hormone family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17301089
uniprot
proteins
pubmed
20501677
uniprot
proteins
pubmed
2249778
uniprot
proteins
pubmed
8314082
uniprot
proteins
pubmed
8895385
uniprot
proteins
sequence_length
175
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P12272}. Cytoplasm {ECO:0000250|UniProtKB:P12272}. Nucleus {ECO:0000250|UniProtKB:P12272}.
uniprot
proteins