C3ar1
entrez
12267
canonical
uniprot
O09047
canonical
ensembl
ENSMUSG00000040552
resolver
ensp
ENSMUSP00000048092
resolver
enst
ENSMUST00000042081
resolver
genesymbol
C3ar1
resolver
genesymbol_syn
C3r1
resolver
uniprot
O35951
resolver
uniprot
Q5U7A4
resolver
uniprot_entry
C3AR_MOUSE
resolver
uniprot_entry
Q5U7A4_MOUSE
resolver
uniprot_sec
O35951
resolver
amino_acid_sequence
MESFDADTNSTDLHSRPLFQPQDIASMVILGLTCLLGLLGNGLVLWVAGVKMKTTVNTVWFLHLTLADFLCCLSLPFSLAHLILQGHWPYGLFLCKLIPSIIILNMFASVFLLTAISLDRCLIVHKPIWCQNHRNVRTAFAICGCVWVVAFVMCVPVFVYRDLFIMDNRSICRYNFDSSRSYDYWDYVYKLSLPESNSTDNSTAQLTGHMNDRSAPSSVQARDYFWTVTTALQSQPFLTSPEDSFSLDSANQQPHYGGKPPNVLTAAVPSGFPVEDRKSNTLNADAFLSAHTELFPTASSGHLYPYDFQGDYVDQFTYDNHVPTPLMAITITRLVVGFLVPFFIMVICYSLIVFRMRKTNFTKSRNKTFRVAVAVVTVFFICWTPYHLVGVLLLITDPESSLGEAVMSWDHMSIALASANSCFNPFLYALLGKDFRKKARQSIKGILEAAFSEELTHSTNCTQDKASSKRNNMSTDV
uniprot
proteins
function
FUNCTION: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a, stimulating chemotaxis, granule enzyme release and superoxide anion production (PubMed:9164946, PubMed:9382922). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). C3AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase (By similarity). {ECO:0000250|UniProtKB:Q16581, ECO:0000269|PubMed:9164946, ECO:0000269|PubMed:9382922}.
uniprot
proteins
mass_dalton
53576
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of the C-terminus by GRK2 or GRK3 promotes association with beta-arrestin (ARRB1), leading to receptor desensitization and negative regulation of G protein-coupled receptor signaling. {ECO:0000250|UniProtKB:Q16581}.; PTM: Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin. {ECO:0000250|UniProtKB:Q16581}.; PTM: O-glycosylated. {ECO:0000250|UniProtKB:Q16581}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25456411
uniprot
proteins
pubmed
9164946
uniprot
proteins
pubmed
9382922
uniprot
proteins
pubmed
9694514
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q16581}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16581}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..46; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 58..80; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 97..118; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 334..353; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 371..393; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 411..431; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins