Lamtor3
entrez
362045
canonical
uniprot
Q5U204
canonical
ensembl
ENSRNOG00000088035
resolver
ensembl
ENSRNOG00055010783
resolver
ensembl
ENSRNOG00060023235
resolver
ensembl
ENSRNOG00065025946
resolver
ensp
ENSRNOP00000105487
resolver
ensp
ENSRNOP00055014625
resolver
ensp
ENSRNOP00060033194
resolver
ensp
ENSRNOP00065036632
resolver
enst
ENSRNOT00000128241
resolver
enst
ENSRNOT00055018215
resolver
enst
ENSRNOT00060040222
resolver
enst
ENSRNOT00065044736
resolver
genesymbol
Lamtor3
resolver
genesymbol_syn
Map2k1ip1
resolver
uniprot_entry
LTOR3_RAT
resolver
amino_acid_sequence
MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDSAPEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSNANTGLIVSLEKELAPLFEELIKVVEVS
uniprot
proteins
function
FUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity). {ECO:0000250|UniProtKB:O88653, ECO:0000250|UniProtKB:Q9UHA4}.
uniprot
proteins
mass_dalton
13580
uniprot
proteins
protein_family
LAMTOR3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
124
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:O88653}; Peripheral membrane protein {ECO:0000250|UniProtKB:O88653}; Cytoplasmic side {ECO:0000250|UniProtKB:O88653}. Note=Recruited to lysosome and endosome membranes by LAMTOR1. {ECO:0000250|UniProtKB:O88653}.
uniprot
proteins