Synj1
entrez
85238
canonical
uniprot
Q62910
canonical
ensembl
ENSRNOG00000002051
resolver
ensp
ENSRNOP00000045019
resolver
ensp
ENSRNOP00000086242
resolver
ensp
ENSRNOP00000092411
resolver
ensp
ENSRNOP00000092530
resolver
enst
ENSRNOT00000096546
resolver
enst
ENSRNOT00000113478
resolver
genesymbol
Synj1
resolver
uniprot
A0A8I6AFG5
resolver
uniprot
A0A8I6AHP8
resolver
uniprot
O89092
resolver
uniprot
Q62911
resolver
uniprot
Q810Z8
resolver
uniprot_entry
A0A8I6AFG5_RAT
resolver
uniprot_entry
A0A8I6AHP8_RAT
resolver
uniprot_entry
SYNJ1_RAT
resolver
uniprot_sec
O89092
resolver
uniprot_sec
Q62911
resolver
uniprot_sec
Q810Z8
resolver
amino_acid_sequence
MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYAKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRVDASDEDRISEVRKVLNSGNFYFAWSASGVSLDLSLNAHRSMQEHTTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVIYLDDCVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKDLYGKQIVVNLLGSKEGEHMLSKAFQSHLKASEHASDIHMVSFDYHQMVKGGKAEKLHSVLKPQVQKFLDYGFFYFDGSAVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKNMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNIVNASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFVEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQIFRGFLEGKVTFAPTYKYDLFSEDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQKIYKEVIAVQGPPDGTVLVSIKSSAQENTFFDDALIDELLQQFAHFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTITITLKSPDWIKTLEEEMSLEKISVTLPSSTSSTLLGEDAEVSADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTAPEYSAPSLPIRPSRAPSRTPGPLSSQGAPVDTQPAAQKESSQTIEPKRPPPPRPVAPPARPAPPQRPPPPSGARSPAPARKEFGGVGAPPSPGVTRREMEAPKSPGTARKDNIGRNQPSPQAGLAGPGPSGYGAARPTIPARAGVISAPQSQARVSAGRLTPESQSKPLETSKGPAVLPEPLKPQAAFPPQPSLPTPAQKLQDPLVPIAAPMPPSIPQSNLETPPLPPPRSRSSQSLPSDSSPQLQQEQPTGQQVKINGACGVKQEPTLKSDPFEDLSLSVLAVSKAQPSAQISPVLTPDPKMLIQLPSASQSKVNSLSSVSCMLTMPPVPEQSKSQESVGSSANPFPSLPTRNPFTDRTAAPGNPFRVQSQESEATSWLSKEEPVSNSPFPPLMPLSHDMSKPSSSLDGFEDNFDLQSQSTVKTSNPKGWVTFDEDEDFPTKGKSRSVYPDSLGNTAASFDDDWSKGTNVSFCVLPARRPPPPPPPVPLLPPGTTSSAGPSTTLSSKASPTLDFTER
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
ec_number
3.1.3.36
uniprot
proteins
ec_number
3.1.3.95
uniprot
proteins
function
FUNCTION: Phosphatase that hydrolyzes phosphate groups from the inositol ring of phosphoinositides and inositol phosphates, in a domain-specific manner (PubMed:8552192, PubMed:9710239). The 5-PPase domain catalyzes removal of the 5-phosphate from substrates such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) (PubMed:8552192, PubMed:9710239). The SAC domain hydrolyzes phosphates at the 3- and 4-positions of the inositol ring, targeting phosphatidylinositol-3-phosphate (PI(3)P), phosphatidylinositol-4-phosphate (PI(4)P), and phosphatidylinositol-3,5-bisphosphate (PI(3,5)P2) (By similarity). Plays a role in the phosphatidylinositol metabolic process during an unconventional endocytic mechanism, the ultrafast endocytosis where it participates in the rapide neck formation of the newly generated synaptic vesicle through its phosphoinositide 5-phosphatase activity (By similarity). Also, participates in the clathrin uncoating of synaptc vesicle formed via budding from synaptic endosomes after ultrafast endocytosis through combined activity of its phosphatase domains (PubMed:9428629). Additionally, regulates actin filament rearrangement by hydrolyzing PIP2 bound to actin regulatory proteins (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:O43426, ECO:0000250|UniProtKB:Q8CHC4, ECO:0000269|PubMed:8552192, ECO:0000269|PubMed:9428629, ECO:0000269|PubMed:9710239}.
uniprot
proteins
mass_dalton
172881
uniprot
proteins
protein_family
4
uniprot
proteins
protein_family
5-trisphosphate 5-phosphatase family
uniprot
proteins
protein_family
Synaptojanin family; Inositol 1
uniprot
proteins
pubmed
17257598
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8552192
uniprot
proteins
pubmed
8798761
uniprot
proteins
pubmed
9238017
uniprot
proteins
pubmed
9341169
uniprot
proteins
pubmed
9428629
uniprot
proteins
pubmed
9710239
uniprot
proteins
sequence_length
1574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:8798761}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O18964}. Presynapse {ECO:0000250|UniProtKB:O43426}. Note=Concentrates at clathrin-coated endocytic intermediates in nerve terminals (PubMed:9428629). Also recruited to clathrin- and dynamin-coated intermediates when brain cytosol was incubated with fibroblastic membranes (our unpublished observations) (PubMed:9428629). {ECO:0000269|PubMed:9428629}.
uniprot
proteins