Cdh1
entrez
12550
canonical
uniprot
P09803
canonical
ensembl
ENSMUSG00000000303
resolver
ensp
ENSMUSP00000000312
resolver
enst
ENSMUST00000000312
resolver
genesymbol
Cdh1
resolver
uniprot
A0A0R4IZW5
resolver
uniprot
Q61377
resolver
uniprot_entry
A0A0R4IZW5_MOUSE
resolver
uniprot_entry
CADH1_MOUSE
resolver
uniprot_sec
Q61377
resolver
amino_acid_sequence
MGARCRSFSALLLLLQVSSWLCQELEPESCSPGFSSEVYTFPVPERHLERGHVLGRVRFEGCTGRPRTAFFSEDSRFKVATDGTITVKRHLKLHKLETSFLVRARDSSHRELSTKVTLKSMGHHHHRHHHRDPASESNPELLMFPSVYPGLRRQKRDWVIPPISCPENEKGEFPKNLVQIKSNRDKETKVFYSITGQGADKPPVGVFIIERETGWLKVTQPLDREAIAKYILYSHAVSSNGEAVEDPMEIVITVTDQNDNRPEFTQEVFEGSVAEGAVPGTSVMKVSATDADDDVNTYNAAIAYTIVSQDPELPHKNMFTVNRDTGVISVLTSGLDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPVFNPSTYQGQVPENEVNARIATLKVTDDDAPNTPAWKAVYTVVNDPDQQFVVVTDPTTNDGILKTAKGLDFEAKQQYILHVRVENEEPFEGSLVPSTATVTVDVVDVNEAPIFMPAERRVEVPEDFGVGQEITSYTAREPDTFMDQKITYRIWRDTANWLEINPETGAIFTRAEMDREDAEHVKNSTYVALIIATDDGSPIATGTGTLLLVLLDVNDNAPIPEPRNMQFCQRNPQPHIITILDPDLPPNTSPFTAELTHGASVNWTIEYNDAAQESLILQPRKDLEIGEYKIHLKLADNQNKDQVTTLDVHVCDCEGTVNNCMKAGIVAAGLQVPAILGILGGILALLILILLLLLFLRRRTVVKEPLLPPDDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPQYRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYGGGEDD
uniprot
proteins
function
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (By similarity). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). {ECO:0000250|UniProtKB:F1PAA9, ECO:0000250|UniProtKB:P12830, ECO:0000269|PubMed:11976333}.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity). {ECO:0000250|UniProtKB:P12830}.; FUNCTION: (Microbial infection) Does not function as a receptor for L.monocytogenes internalin A (InlA); mutating a single surface-exposed residue confers receptor activity to this protein and promotes uptake of the bacteria. {ECO:0000269|PubMed:10406800}.
uniprot
proteins
mass_dalton
98256
uniprot
proteins
mutagenesis
MUTAGEN 172; /note="E->P: Adheres to and takes up L.monocytogenes InlA coated beads."; /evidence="ECO:0000269|PubMed:10406800"; MUTAGEN 220; /note="Q->E: Increased affinity for L.monocytogenes InlA. Greatly increased affinity; when associated with P-172."; /evidence="ECO:0000269|PubMed:17540170
uniprot
proteins
post_translational_modification
PTM: During apoptosis or with calcium influx, cleaved by a membrane-bound metalloproteinase (ADAM10), PS1/gamma-secretase and caspase-3 (By similarity). Processing by the metalloproteinase, induced by calcium influx, causes disruption of cell-cell adhesion and the subsequent release of beta-catenin into the cytoplasm (By similarity). The residual membrane-tethered cleavage product is rapidly degraded via an intracellular proteolytic pathway (By similarity). Cleavage by caspase-3 releases the cytoplasmic tail resulting in disintegration of the actin microfilament system (By similarity). The gamma-secretase-mediated cleavage promotes disassembly of adherens junctions (By similarity). During development of the cochlear organ of Corti, cleavage by ADAM10 at adherens junctions promotes pillar cell separation (PubMed:30639848). {ECO:0000250|UniProtKB:P12830, ECO:0000269|PubMed:30639848}.; PTM: O-glycosylated. O-manosylated by TMTC1, TMTC2, TMTC3 or TMTC4. Ser-287 and Thr-511 are O-manosylated by TMTC2 or TMTC4 but not TMTC1 or TMTC3. {ECO:0000269|PubMed:28973932}.; PTM: N-glycosylation at Asn-639 is essential for expression, folding and trafficking. Addition of bisecting N-acetylglucosamine by MGAT3 modulates its cell membrane location (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P12830}.; PTM: Ubiquitinated by a SCF complex containing SKP2, which requires prior phosphorylation by CK1/CSNK1A1. Ubiquitinated by CBLL1/HAKAI, requires prior phosphorylation at Tyr-756 (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
10406800
uniprot
proteins
pubmed
11348595
uniprot
proteins
pubmed
11976333
uniprot
proteins
pubmed
12494996
uniprot
proteins
pubmed
16325582
uniprot
proteins
pubmed
17540170
uniprot
proteins
pubmed
1754391
uniprot
proteins
pubmed
1763063
uniprot
proteins
pubmed
18079750
uniprot
proteins
pubmed
18093941
uniprot
proteins
pubmed
19759396
uniprot
proteins
pubmed
20413591
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27375112
uniprot
proteins
pubmed
27760340
uniprot
proteins
pubmed
28973932
uniprot
proteins
pubmed
30639848
uniprot
proteins
pubmed
30660666
uniprot
proteins
pubmed
34905516
uniprot
proteins
pubmed
3498123
uniprot
proteins
pubmed
3501370
uniprot
proteins
pubmed
7982500
uniprot
proteins
pubmed
8598933
uniprot
proteins
pubmed
8785495
uniprot
proteins
pubmed
8879495
uniprot
proteins
pubmed
9864371
uniprot
proteins
sequence_length
884
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:12494996, ECO:0000269|PubMed:27375112, ECO:0000269|PubMed:30639848}. Cell membrane {ECO:0000269|PubMed:27760340, ECO:0000269|PubMed:9864371}; Single-pass type I membrane protein. Endosome {ECO:0000250|UniProtKB:P12830}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P12830}. Cytoplasm {ECO:0000269|PubMed:27375112, ECO:0000269|PubMed:27760340}. Cell junction, desmosome {ECO:0000250|UniProtKB:P12830}. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane (By similarity). Recruited to desmosomes at the initial assembly phase and also accumulates progressively at mature desmosome cell-cell junctions (By similarity). Localizes to cell-cell contacts as keratinocyte differentiation progresses (PubMed:27375112). {ECO:0000250, ECO:0000250|UniProtKB:P12830, ECO:0000269|PubMed:27375112}.
uniprot
proteins
transmembrane_region
TRANSMEM 710..733; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins