Gde1
entrez
56209
canonical
uniprot
Q9JL56
canonical
ensembl
ENSMUSG00000033917
resolver
ensp
ENSMUSP00000046371
resolver
enst
ENSMUST00000038791
resolver
genesymbol
Gde1
resolver
genesymbol_syn
Mir16
resolver
uniprot
Q3UBU4
resolver
uniprot_entry
GDE1_MOUSE
resolver
uniprot_sec
Q3UBU4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by EDTA, calcium chloride, and zinc chloride (PubMed:18227059, PubMed:25596343). Enhanced by magnesium chloride (PubMed:18227059, PubMed:25596343). Glycerophosphodiester phosphodiesterase activity can be modulated by G protein signaling pathways (By similarity). {ECO:0000250|UniProtKB:Q9JL55, ECO:0000269|PubMed:18227059, ECO:0000269|PubMed:25596343}.
uniprot
proteins
amino_acid_sequence
MWLWEDQGGLLGPFSFVLVLLLVVTRSPFNACVLTGSLYILLRFFSFEPVPSRRALQVLKPRDRVSAIAHRGGSHDAPENTLAAIRQAAKNGATGVELDIEFTSDGVPVLMHDNTVDRTTDGSGRLCDLTFEQVRKLNPAANHRLRNEFPDERIPTLKEAVTECLRHNLTIFFDVKGHADMASAALKNIYTEFPQLYNNSMVCSFLPEVIYKMRQTDQKVITALTHRPWSLSHTGDGKPRYSVFWKQSVFVVLDILLDWSMHNVLWYLCGISAFLMQKDFVSPDYLKKWSAKGIQVVSWTVNTFDEKNYYESHLGSSYITDSMLEDCAPHF
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
ec_number
3.1.4.44
uniprot
proteins
function
FUNCTION: Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (PubMed:18227059, PubMed:21801852, PubMed:25596343). Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic) (PubMed:18227059). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine (PubMed:21801852, PubMed:25596343). However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (PubMed:21801852, PubMed:25596343). Has little or no activity towards glycerophosphocholine (By similarity). {ECO:0000250|UniProtKB:Q9JL55, ECO:0000269|PubMed:18227059, ECO:0000269|PubMed:21801852, ECO:0000269|PubMed:25596343}.
uniprot
proteins
mass_dalton
37629
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:18227059}.
uniprot
proteins
protein_family
Glycerophosphoryl diester phosphodiesterase family
uniprot
proteins
pubmed
10760272
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18227059
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21801852
uniprot
proteins
pubmed
25596343
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18227059}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9JL55}; Multi-pass membrane protein {ECO:0000255}. Note=Perinuclear vesicles and cell membrane. {ECO:0000250|UniProtKB:Q9JL55}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 249..269; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins