Bace1
entrez
29392
canonical
uniprot
P56819
canonical
ensembl
ENSRNOG00000016847
resolver
ensembl
ENSRNOG00055020254
resolver
ensembl
ENSRNOG00060013805
resolver
ensembl
ENSRNOG00065027571
resolver
ensp
ENSRNOP00000022796
resolver
ensp
ENSRNOP00055028025
resolver
ensp
ENSRNOP00060018727
resolver
ensp
ENSRNOP00065039004
resolver
enst
ENSRNOT00000022796
resolver
enst
ENSRNOT00055034589
resolver
enst
ENSRNOT00060023572
resolver
enst
ENSRNOT00065047536
resolver
genesymbol
Bace1
resolver
genesymbol_syn
Bace
resolver
uniprot_entry
BACE1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by RTN3 and RTN4. {ECO:0000250|UniProtKB:P56817}.
uniprot
proteins
amino_acid_sequence
MAPALRWLLLWVGSGMLPAQGTHLGIRLPLRSGLAGPPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKSVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK
uniprot
proteins
ec_number
3.4.23.46
uniprot
proteins
function
FUNCTION: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (By similarity). Cleaves CHL1 (By similarity). {ECO:0000250|UniProtKB:P56817, ECO:0000250|UniProtKB:P56818}.
uniprot
proteins
mass_dalton
55807
uniprot
proteins
post_translational_modification
PTM: Palmitoylation mediates lipid raft localization. {ECO:0000250|UniProtKB:P56818}.; PTM: Acetylated in the endoplasmic reticulum at Lys-126, Lys-275, Lys-279, Lys-285, Lys-299, Lys-300 and Lys-307. Acetylation by NAT8 and NAT8B is transient and deacetylation probably occurs in the Golgi. Acetylation regulates the maturation, the transport to the plasma membrane, the stability and the expression of the protein. {ECO:0000250|UniProtKB:P56817}.; PTM: Ubiquitinated at Lys-501, ubiquitination leads to lysosomal degradation. Monoubiquitinated and 'Lys-63'-linked polyubitinated. Deubiquitnated by USP8; inhibits lysosomal degradation. {ECO:0000250|UniProtKB:P56817}.; PTM: Phosphorylation at Ser-498 is required for interaction with GGA1 and retrograded transport from endosomal compartments to the trans-Golgi network. Non-phosphorylated BACE1 enters a direct recycling route to the cell surface. {ECO:0000250|UniProtKB:P56817}.; PTM: N-Glycosylated (By similarity). Addition of a bisecting N-acetylglucosamine by MGAT3 blocks lysosomal targeting, further degradation and is required for maintaining stability under stress conditions (By similarity). {ECO:0000250|UniProtKB:P56817, ECO:0000250|UniProtKB:P56818}.
uniprot
proteins
protein_family
Peptidase A1 family
uniprot
proteins
pubmed
10531052
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P56817}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P56817}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P56817}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P56817}. Endosome {ECO:0000250|UniProtKB:P56817}. Cell surface {ECO:0000250|UniProtKB:P56817}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P56817}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P56817}. Membrane raft {ECO:0000250|UniProtKB:P56818}. Lysosome {ECO:0000250|UniProtKB:P56817}. Late endosome {ECO:0000250|UniProtKB:P56817}. Early endosome {ECO:0000250|UniProtKB:P56817}. Recycling endosome {ECO:0000250|UniProtKB:P56817}. Cell projection, axon {ECO:0000250|UniProtKB:P56818}. Cell projection, dendrite {ECO:0000250|UniProtKB:P56818}. Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (By similarity). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine which blocks targeting to late endosomes and lysosomes (By similarity). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (By similarity). {ECO:0000250|UniProtKB:P56817, ECO:0000250|UniProtKB:P56818}.
uniprot
proteins
transmembrane_region
TRANSMEM 458..478; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins