SPAG9
entrez
9043
canonical
uniprot
O60271
canonical
ensembl
ENSG00000008294
resolver
ensp
ENSP00000262013
resolver
ensp
ENSP00000349636
resolver
ensp
ENSP00000423165
resolver
ensp
ENSP00000426900
resolver
ensp
ENSP00000525160
resolver
ensp
ENSP00000525163
resolver
genesymbol
SPAG9
resolver
genesymbol_syn
HSS
resolver
genesymbol_syn
KIAA0516
resolver
genesymbol_syn
MAPK8IP4
resolver
genesymbol_syn
SYD1
resolver
hgnc
HGNC:14524
resolver
uniprot
A6H8U5
resolver
uniprot
A8MSX0
resolver
uniprot
B4DHH2
resolver
uniprot
O60905
resolver
uniprot
Q3KQU8
resolver
uniprot
Q3MKM7
resolver
uniprot
Q5JB53
resolver
uniprot
Q86WC7
resolver
uniprot
Q86WC8
resolver
uniprot
Q8IZX7
resolver
uniprot
Q96II0
resolver
uniprot
Q9H811
resolver
uniprot_entry
JIP4_HUMAN
resolver
uniprot_entry
Q5JB53_HUMAN
resolver
uniprot_sec
A6H8U5
resolver
uniprot_sec
A8MSX0
resolver
uniprot_sec
B4DHH2
resolver
uniprot_sec
O60905
resolver
uniprot_sec
Q3KQU8
resolver
uniprot_sec
Q3MKM7
resolver
uniprot_sec
Q86WC7
resolver
uniprot_sec
Q86WC8
resolver
uniprot_sec
Q8IZX7
resolver
uniprot_sec
Q96II0
resolver
uniprot_sec
Q9H811
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform 5]: May play a role in spermatozoa-egg-interaction. {ECO:0000269|PubMed:15693750}.
uniprot
proteins
amino_acid_sequence
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGNE
uniprot
proteins
function
FUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}.
uniprot
proteins
mass_dalton
146205
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK8 and MAPK14. {ECO:0000250}.
uniprot
proteins
protein_family
JIP scaffold family
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12391307
uniprot
proteins
pubmed
14662895
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14743216
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15693750
uniprot
proteins
pubmed
16112646
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19644450
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29146937
uniprot
proteins
pubmed
9480848
uniprot
proteins
pubmed
9628581
uniprot
proteins
sequence_length
1321
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q58A65}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q58A65}. Lysosome membrane {ECO:0000269|PubMed:29146937}. Note=Perinuclear distribution in response to stress signals such as UV radiation. {ECO:0000250|UniProtKB:Q58A65}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:15693750}. Note=Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix. {ECO:0000269|PubMed:15693750}.
uniprot
proteins