TEPSIN
entrez
146705
canonical
uniprot
Q96N21
canonical
ensembl
ENSG00000167302
resolver
ensp
ENSP00000300714
resolver
ensp
ENSP00000490393
resolver
ensp
ENSP00000553855
resolver
enst
ENST00000637944
resolver
genesymbol
TEPSIN
resolver
genesymbol_syn
C17orf56
resolver
genesymbol_syn
ENTHD2
resolver
hgnc
HGNC:26458
resolver
uniprot
A0A1B0GV70
resolver
uniprot
Q6ZQU0
resolver
uniprot
Q6ZSQ9
resolver
uniprot_entry
A0A1B0GV70_HUMAN
resolver
uniprot_entry
AP4AT_HUMAN
resolver
uniprot_sec
Q6ZQU0
resolver
uniprot_sec
Q6ZSQ9
resolver
amino_acid_sequence
MAAAPPLRDRLSFLHRLPILLKGTSDDDVPCPGYLFEEIAKISHESPGSSQCLLEYLLSRLHSSSGHGKLKVLKILLYLCSHGSSFFLLILKRNSAFIQEAAAFAGPPDPLHGNSLYQKVRAAAQDLGSTLFSDTVLPLAPSQPLGTPPATGMGSQARPHSTLQGFGYSKEHGRTAVRHQPGQAGGGWDELDSGPSSQNSSQNSDLSRVSDSGSHSGSDSHSGASREPGDLAERVEVVALSDCQQELSLVRTVTRGPRAFLSREEAQHFIKACGLLNCEAVLQLLTCHLRGTSECTQLRALCAIASLGSSDLLPQEHILLRTRPWLQELSMGSPGPVTNKATKILRHFEASCGQLSPARGTSAEPGPTAALPGPSDLLTDAVPLPGSQVFLQPLSSTPVSSRSPAPSSGMPSSPVPTPPPDASPIPAPGDPSEAEARLAESRRWRPERIPGGTDSPKRGPSSCAWSRDSLFAGMELVACPRLVGAGAAAGESCPDAPRAPQTSSQRTAAKEPPGSEPSAFAFLNA
uniprot
proteins
function
FUNCTION: Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000305|PubMed:22472443, ECO:0000305|PubMed:26542808}.
uniprot
proteins
mass_dalton
55137
uniprot
proteins
mutagenesis
MUTAGEN 467; /note="R->A: No effect on interaction with AP4B1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 468; /note="D->A: No effect on interaction with AP4B1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 469; /note="S->A,P: No effect on interaction with AP4B1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 470; /note="L->A: Loss of interaction with AP4B1 n vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 470; /note="L->S: Loss of interaction with AP4B1 in vitro; when associated with S-471."; /evidence="ECO:0000269|PubMed:26756312"; MUTAGEN 471; /note="F->A: Loss of interaction with AP4B1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 471; /note="F->S: Loss of interaction with AP4B1 in vitro; when associated with S-470."; /evidence="ECO:0000269|PubMed:26756312"; MUTAGEN 472; /note="A->D,P: No effect on interaction with AP4B1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 473; /note="G->A: No effect on interaction with AP4B1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 473; /note="G->I: Loss of interaction with AP4B1 in vitro; when associated with Q-474."; /evidence="ECO:0000269|PubMed:26756312"; MUTAGEN 474; /note="M->A: Decreased interaction with AP4B1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 474; /note="M->D: Decreased interaction with AP4B1 in vitro; when associated with A-476."; /evidence="ECO:0000269|PubMed:26756312"; MUTAGEN 474; /note="M->Q: Loss of interaction with AP4B1 in vitro; when associated with I-473."; /evidence="ECO:0000269|PubMed:26756312"; MUTAGEN 475; /note="E->A: No effect on interaction with AP4B1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 476; /note="L->A: No effect on interaction with AP4B1 in vitro. Decreased interaction with AP4B1; when associated with D-474."; /evidence="ECO:0000269|PubMed:26542808, ECO:0000269|PubMed:26756312"; MUTAGEN 476; /note="L->S: Decreased interaction with AP4B1 in vitro; when associated with S-477."; /evidence="ECO:0000269|PubMed:26756312"; MUTAGEN 477; /note="V->A: No effect on interaction with AP4B1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 477; /note="V->S: Decreased interaction with AP4B1 in vitro; when associated with S-476."; /evidence="ECO:0000269|PubMed:26756312"; MUTAGEN 516; /note="E->A: No effect on interaction with AP4E1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 517; /note="P->A: No effect on interaction with AP4E1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 518; /note="S->A: Loss of interaction with AP4E1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 519; /note="A->D: Loss of interaction with AP4E1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 520; /note="F->A: Loss of interaction with AP4E1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 521; /note="A->D: No effect on interaction with AP4E1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 522; /note="F->A: Loss of interaction with AP4E1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 523; /note="L->A: Loss of interaction with AP4E1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 524; /note="N->A: Decreased interaction with AP4E1 in vitro."; /evidence="ECO:0000269|PubMed:26542808"; MUTAGEN 525; /note="A->D: No effect on interaction with AP4E1 in vitro."; /evidence="ECO:0000269|PubMed:26542808
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22472443
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26542808
uniprot
proteins
pubmed
26756312
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:26542808, ECO:0000269|PubMed:26756312}; Peripheral membrane protein {ECO:0000269|PubMed:26756312}. Cytoplasmic vesicle {ECO:0000269|PubMed:22472443}. Cytoplasm, cytosol {ECO:0000269|PubMed:22472443}. Note=Extensively colocalizes with AP-4 which mediates the recruitment of TEPSIN to the trans-Golgi network. {ECO:0000269|PubMed:22472443, ECO:0000269|PubMed:26542808}.
uniprot
proteins