TAOK2
entrez
9344
canonical
uniprot
Q9UL54
canonical
ensembl
ENSG00000149930
resolver
ensp
ENSP00000279394
resolver
ensp
ENSP00000310094
resolver
ensp
ENSP00000440336
resolver
ensp
ENSP00000582439
resolver
ensp
ENSP00000748614
resolver
genesymbol
TAOK2
resolver
genesymbol_syn
KIAA0881
resolver
genesymbol_syn
MAP3K17
resolver
genesymbol_syn
PSK
resolver
genesymbol_syn
PSK1
resolver
hgnc
HGNC:16835
resolver
uniprot
A5PKY1
resolver
uniprot
A7MCZ2
resolver
uniprot
B2RN35
resolver
uniprot
B7ZM88
resolver
uniprot
O94957
resolver
uniprot
Q6UW73
resolver
uniprot
Q7LC09
resolver
uniprot
Q9NSW2
resolver
uniprot_entry
TAOK2_HUMAN
resolver
uniprot_sec
A5PKY1
resolver
uniprot_sec
A7MCZ2
resolver
uniprot_sec
B2RN35
resolver
uniprot_sec
B7ZM88
resolver
uniprot_sec
O94957
resolver
uniprot_sec
Q6UW73
resolver
uniprot_sec
Q7LC09
resolver
uniprot_sec
Q9NSW2
resolver
activity_regulation
ACTIVITY REGULATION: Selectively inhibited by the enantiopure organoruthenium inhibitor 9E1. Activated following arsenic trioxide (As(2)O(3)) treatment. {ECO:0000269|PubMed:19226137, ECO:0000269|PubMed:20159944}.
uniprot
proteins
amino_acid_sequence
MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQEAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVWGLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQGPALTPVPEEEEEEEEGAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHGLLAGLSFAVGSSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTALHLPSSLFLLLAQGTALGAVLGLSWRRGLMGVPLGLGAAWLLAWPGLALPLVAMAAGGRWVRQQGPRVRRGISRLWLRVLLRLSPMAFRALQGCGAVGDRGLFALYPKTNKDGFRSRLPVPGPRRRNPRTTQHPLALLARVWVLCKGWNWRLARASQGLASHLPPWAIHTLASWGLLRGERPTRIPRLLPRSQRQLGPPASRQPLPGTLAGRRSRTRQSRALPPWR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}.
uniprot
proteins
mass_dalton
138251
uniprot
proteins
mutagenesis
MUTAGEN 57; /note="K->A: Loss of kinase activity. In isoform 1, excluded from the nucleus. No effect on microtubule-binding."; /evidence="ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878"; MUTAGEN 169; /note="D->A: Loss of kinase activity; No effect on MAP3K7-mediated activation of NF-kappa-B."; /evidence="ECO:0000269|PubMed:16893890"; MUTAGEN 919; /note="D->N: No effect on kinase activity, nor on JNK activation, but severe reduction in nuclear localization and apoptotic membrane blebbing."; /evidence="ECO:0000269|PubMed:17158878
uniprot
proteins
post_translational_modification
PTM: Isoforms 1 and 2 are autophosphorylated.; PTM: C-terminal cleavage of isoform 1 and subsequent nuclear localization requires CASP9 activity.; PTM: Autophosphorylated. Phosphorylated by ATM.; PTM: [Isoform 2]: Phosphorylated on Ser-1031 by MAPK14. This phosphorylation is required PCDH8 for endocytosis (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
10660600
uniprot
proteins
pubmed
11279118
uniprot
proteins
pubmed
12639963
uniprot
proteins
pubmed
12665513
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
13679851
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16893890
uniprot
proteins
pubmed
17158878
uniprot
proteins
pubmed
17396146
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19226137
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20159944
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
1235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton. Nucleus. Note=Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Cell projection, dendrite. Note=In dendrites, colocalizes with PCDH8. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 965..985; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 987..1007; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1012..1032; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1043..1063; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1166..1186; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins