CEL
entrez
1056
canonical
uniprot
P19835
canonical
ensembl
ENSG00000170835
resolver
ensp
ENSP00000361151
resolver
genesymbol
CEL
resolver
genesymbol_syn
BAL
resolver
hgnc
HGNC:1848
resolver
uniprot
B4DSX9
resolver
uniprot
O75612
resolver
uniprot
Q16398
resolver
uniprot
Q5T7U7
resolver
uniprot
Q86SR3
resolver
uniprot
Q9UCH1
resolver
uniprot
Q9UP41
resolver
uniprot_entry
B4DSX9_HUMAN
resolver
uniprot_entry
CEL_HUMAN
resolver
uniprot_entry
O75612_HUMAN
resolver
uniprot_entry
Q86SR3_HUMAN
resolver
uniprot_sec
Q16398
resolver
uniprot_sec
Q5T7U7
resolver
uniprot_sec
Q9UCH1
resolver
uniprot_sec
Q9UP41
resolver
activity_regulation
ACTIVITY REGULATION: Activated by bile salts such as sodium taurocholate. {ECO:0000269|PubMed:10220579}.
uniprot
proteins
amino_acid_sequence
MGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIRF
uniprot
proteins
disease_involvement
DISEASE: Maturity-onset diabetes of the young 8 with exocrine dysfunction (MODY8) [MIM:609812]: An autosomal dominant form of diabetes characterized by a primary defect in insulin secretion, exocrine pancreatic dysfunction, altered pancreatic morphology, recurrent abdominal pain, and fecal elastase deficiency. Disease onset is at less than 25 years of age. {ECO:0000269|PubMed:16369531}. Note=The disease is caused by variants affecting the gene represented in this entry. Single base deletions in the VNTR-region, that result in frame shift and protein truncation, have been identified as disease causing variants in MODY8 families (PubMed:16369531). {ECO:0000269|PubMed:16369531}.
uniprot
proteins
ec_number
3.1.1.13
uniprot
proteins
ec_number
3.1.1.3
uniprot
proteins
ec_number
3.1.1.6
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs) (PubMed:10220579, PubMed:27509211, PubMed:27650499, PubMed:8471055). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (PubMed:10220579, PubMed:27509211, PubMed:27650499, PubMed:8471055). {ECO:0000250|UniProtKB:Q64285, ECO:0000269|PubMed:10220579, ECO:0000269|PubMed:27509211, ECO:0000269|PubMed:27650499, ECO:0000269|PubMed:8471055}.
uniprot
proteins
mass_dalton
79322
uniprot
proteins
mutagenesis
MUTAGEN 455; /note="H->Q: Abolishes lipase activity. Decreases Vmax for esterase activity by 2.5-fold."; /evidence="ECO:0000269|PubMed:8471055
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated. {ECO:0000269|PubMed:21784842}.
uniprot
proteins
protein_family
Type-B carboxylesterase/lipase family
uniprot
proteins
pubmed
10024660
uniprot
proteins
pubmed
10220579
uniprot
proteins
pubmed
11045623
uniprot
proteins
pubmed
11834744
uniprot
proteins
pubmed
12166660
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
16369531
uniprot
proteins
pubmed
1639390
uniprot
proteins
pubmed
1698625
uniprot
proteins
pubmed
19760265
uniprot
proteins
pubmed
1988041
uniprot
proteins
pubmed
1991511
uniprot
proteins
pubmed
21784842
uniprot
proteins
pubmed
2265692
uniprot
proteins
pubmed
27509211
uniprot
proteins
pubmed
27650499
uniprot
proteins
pubmed
7578248
uniprot
proteins
pubmed
7654718
uniprot
proteins
pubmed
8471055
uniprot
proteins
pubmed
9530636
uniprot
proteins
sequence_length
753
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21784842}.
uniprot
proteins