Cxxc5
entrez
67393
canonical
uniprot
Q91WA4
canonical
ensembl
ENSMUSG00000046668
resolver
ensp
ENSMUSP00000054307
resolver
ensp
ENSMUSP00000291691
resolver
ensp
ENSMUSP00000291698
resolver
ensp
ENSMUSP00000291704
resolver
ensp
ENSMUSP00000340080
resolver
enst
ENSMUST00000060722
resolver
genesymbol
Cxxc5
resolver
uniprot
Q3V0R4
resolver
uniprot
Q8CES6
resolver
uniprot
Q8CF49
resolver
uniprot_entry
CXXC5_MOUSE
resolver
uniprot_sec
Q3V0R4
resolver
uniprot_sec
Q8CES6
resolver
uniprot_sec
Q8CF49
resolver
amino_acid_sequence
MSSLGGGSQDAGGSSSSSNTNSSSGSGQKAGGTDKSTAVAATTAPTSVADDAPPPERRNKSGIISEPLNKSLRRSRPLSHYSSFGSSGGGGSMMGVESADKAAAAAASLLANGHDLAAAMAVDKSNPTSKHKSGAVASLLSKAERATELAAEGQLTLQQFAQSTEMLKRVVQEHLPLMSEAGAGLPDMEAVAGAEALNGQSDFPYLGAFPINPGLFIMTPAGVFLAESALHMAGLAEYPMQGELASAISSGKKKRKRCGMCAPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSAALEKVMLPSGAAFRWFQ
uniprot
proteins
function
FUNCTION: May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity). {ECO:0000250|UniProtKB:Q5XIQ3, ECO:0000250|UniProtKB:Q7LFL8}.
uniprot
proteins
mass_dalton
32812
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19001364
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5XIQ3}. Cytoplasm {ECO:0000250|UniProtKB:Q5XIQ3}. Note=Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane. {ECO:0000250|UniProtKB:Q5XIQ3}.
uniprot
proteins