Prom1
entrez
19126
canonical
uniprot
O54990
canonical
ensembl
ENSMUSG00000029086
resolver
ensp
ENSMUSP00000030973
resolver
ensp
ENSMUSP00000073751
resolver
ensp
ENSMUSP00000084707
resolver
ensp
ENSMUSP00000084709
resolver
ensp
ENSMUSP00000128978
resolver
ensp
ENSMUSP00000129909
resolver
ensp
ENSMUSP00000136483
resolver
ensp
ENSMUSP00000137557
resolver
ensp
ENSMUSP00000142375
resolver
ensp
ENSMUSP00000142632
resolver
ensp
ENSMUSP00000229828
resolver
ensp
ENSMUSP00000229829
resolver
ensp
ENSMUSP00000229838
resolver
ensp
ENSMUSP00000229839
resolver
ensp
ENSMUSP00000229840
resolver
enst
ENSMUST00000030973
resolver
enst
ENSMUST00000074113
resolver
enst
ENSMUST00000087441
resolver
enst
ENSMUST00000087442
resolver
enst
ENSMUST00000165909
resolver
enst
ENSMUST00000171543
resolver
enst
ENSMUST00000177946
resolver
enst
ENSMUST00000179059
resolver
enst
ENSMUST00000197706
resolver
enst
ENSMUST00000197750
resolver
genesymbol
Prom1
resolver
genesymbol_syn
Prom
resolver
genesymbol_syn
Proml1
resolver
uniprot
A0A0G2JDH9
resolver
uniprot
A0A0G2JE50
resolver
uniprot
A0A0R4J0B0
resolver
uniprot
F7ATA6
resolver
uniprot
G3X9J8
resolver
uniprot
G5E8G5
resolver
uniprot
J3QPZ7
resolver
uniprot
O35408
resolver
uniprot
Q80XB2
resolver
uniprot
Q80XB3
resolver
uniprot
Q80XB6
resolver
uniprot
Q8BH12
resolver
uniprot
Q8CDK8
resolver
uniprot
Q8R056
resolver
uniprot_entry
A0A0G2JDH9_MOUSE
resolver
uniprot_entry
A0A0G2JE50_MOUSE
resolver
uniprot_entry
A0A0R4J0B0_MOUSE
resolver
uniprot_entry
F7ATA6_MOUSE
resolver
uniprot_entry
G3X9J8_MOUSE
resolver
uniprot_entry
G5E8G5_MOUSE
resolver
uniprot_entry
J3QPZ7_MOUSE
resolver
uniprot_entry
PROM1_MOUSE
resolver
uniprot_entry
Q8CDK8_MOUSE
resolver
uniprot_entry
Q8R056_MOUSE
resolver
uniprot_sec
O35408
resolver
uniprot_sec
Q80XB2
resolver
uniprot_sec
Q80XB3
resolver
uniprot_sec
Q80XB6
resolver
uniprot_sec
Q8BH12
resolver
amino_acid_sequence
MALVFSALLLLGLCGKISSEGQPAFHNTPGAMNYELPTTKYETQDTFNAGIVGPLYKMVHIFLSVVQPNDFPLDLIKKLIQNKKFDISVDSKEPEIIVLALKIALYEIGVLICAILGLLFIILMPLVGCFFCMCRCCNKCGGEMHQRQKQNAPCRRKCLGLSLLVICLLMSLGIIYGFVANQQTRTRIKGTQKLAKSNFRDFQTLLTETPKQIDYVVEQYTNTKNKAFSDLDGIGSVLGGRIKDQLKPKVTPVLEEIKAMATAIKQTKDALQNMSSSLKSLQDAATQLNTNLSSVRNSIENSLSSSDCTSDPASKICDSIRPSLSSLGSSLNSSQLPSVDRELNTVTEVDKTDLESLVKRGYTTIDEIPNTIQNQTVDVIKDVKNTLDSISSNIKDMSQSIPIEDMLLQVSHYLNNSNRYLNQELPKLEEYDSYWWLGGLIVCFLLTLIVTFFFLGLLCGVFGYDKHATPTRRGCVSNTGGIFLMAGVGFGFLFCWILMILVVLTFVVGANVEKLLCEPYENKKLLQVLDTPYLLKEQWQFYLSGMLFNNPDINMTFEQVYRDCKRGRGIYAAFQLENVVNVSDHFNIDQISENINTELENLNVNIDSIELLDNTGRKSLEDFAHSGIDTIDYSTYLKETEKSPTEVNLLTFASTLEAKANQLPEGKPKQAFLLDVQNIRAIHQHLLPPVQQSLNTLRQSVWTLQQTSNKLPEKVKKILASLDSVQHFLTNNVSLIVIGETKKFGKTILGYFEHYLHWVFYAITEKMTSCKPMATAMDSAVNGILCGYVADPLNLFWFGIGKATVLLLPAVIIAIKLAKYYRRMDSEDVYDDVETVPMKNLEIGSNGYHKDHLYGVHNPVMTSPSRY
uniprot
proteins
function
FUNCTION: May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis (PubMed:19228982). Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. {ECO:0000269|PubMed:19228982}.
uniprot
proteins
mass_dalton
97113
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-226, Lys-258 and Lys-265 by NAT8 and NAT8B may control PROM1 protein expression and its function in cell apoptosis.
uniprot
proteins
protein_family
Prominin family
uniprot
proteins
pubmed
10980698
uniprot
proteins
pubmed
12514187
uniprot
proteins
pubmed
15316084
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17109118
uniprot
proteins
pubmed
17283184
uniprot
proteins
pubmed
17498271
uniprot
proteins
pubmed
17874118
uniprot
proteins
pubmed
18654668
uniprot
proteins
pubmed
19228982
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9356465
uniprot
proteins
pubmed
9389721
uniprot
proteins
sequence_length
867
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Cell projection, microvillus membrane; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Endoplasmic reticulum {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Note=Found in extracellular membrane particles in various body fluids such as ventricular fluid of the developing brain and urine.
uniprot
proteins
transmembrane_region
TRANSMEM 108..128; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 159..179; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 435..455; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 488..508; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 795..815; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins