Ccnh
entrez
84389
canonical
uniprot
Q9R1A0
canonical
ensembl
ENSRNOG00000031656
resolver
ensembl
ENSRNOG00055004021
resolver
ensembl
ENSRNOG00060000742
resolver
ensembl
ENSRNOG00065005503
resolver
ensp
ENSRNOP00000039039
resolver
ensp
ENSRNOP00055004908
resolver
ensp
ENSRNOP00060000217
resolver
ensp
ENSRNOP00065005704
resolver
enst
ENSRNOT00000049423
resolver
enst
ENSRNOT00055006415
resolver
enst
ENSRNOT00060000870
resolver
enst
ENSRNOT00065008150
resolver
genesymbol
Ccnh
resolver
uniprot
Q99JE5
resolver
uniprot_entry
CCNH_RAT
resolver
uniprot_sec
Q99JE5
resolver
amino_acid_sequence
MYHNSSQKRHWTFASEEQLARLRADANRKFKCKAVANGKVLPNDPLFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDIKTRYPMLENPEILRKTADDFLSRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAILKQKLERCHSSDLALNMVTKKRKGYEDDDYVSKKPKQEEEEWTDDDLVDAL
uniprot
proteins
function
FUNCTION: Component of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalyzing the activating threonine phosphorylation of CDKs. Binds and activates cyclin-dependent protein kinase CDK7, the catalytic subunit of CAK (By similarity). CAK activates major mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, and plays a key role in regulating cell cycle progression (By similarity). CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts (By similarity). Involved in cell cycle control and in RNA transcription by RNA polymerase II (By similarity). Its expression and activity are constant throughout the cell cycle. {ECO:0000250|UniProtKB:P51946}.
uniprot
proteins
mass_dalton
37610
uniprot
proteins
protein_family
Cyclin C subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
10501206
uniprot
proteins
pubmed
11252168
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins