Cd9
entrez
24936
canonical
uniprot
P40241
canonical
ensembl
ENSRNOG00000019556
resolver
ensembl
ENSRNOG00055010243
resolver
ensembl
ENSRNOG00060023442
resolver
ensembl
ENSRNOG00065033344
resolver
ensp
ENSRNOP00000026633
resolver
ensp
ENSRNOP00055013910
resolver
ensp
ENSRNOP00060033577
resolver
ensp
ENSRNOP00065047160
resolver
enst
ENSRNOT00000026633
resolver
enst
ENSRNOT00055017304
resolver
enst
ENSRNOT00060040626
resolver
enst
ENSRNOT00065057319
resolver
genesymbol
Cd9
resolver
uniprot
B1WBM0
resolver
uniprot_entry
B1WBM0_RAT
resolver
uniprot_entry
CD9_RAT
resolver
amino_acid_sequence
MPVKGGSKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNHSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAVWGYTHKDEVIKELQEFYKDTYQKLRNKDEPQRETLKAIHMALNCCGIAGGVEQFISDICPKKQVLESFQVKSCPDAIDEVFHSKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRSREMV
uniprot
proteins
function
FUNCTION: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (By similarity). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (By similarity). {ECO:0000250|UniProtKB:P21926, ECO:0000250|UniProtKB:P40240}.
uniprot
proteins
mass_dalton
25215
uniprot
proteins
post_translational_modification
PTM: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion. {ECO:0000250|UniProtKB:P21926}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
7823164
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P40240}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P40240}. Membrane {ECO:0000250|UniProtKB:P40240}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P40240}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P40240}. Note=Present at the cell surface of oocytes. Accumulates in the adhesion area between the sperm and egg following interaction between IZUMO1 and its receptor IZUMO1R/JUNO. {ECO:0000250|UniProtKB:P40240}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 54..74; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 86..109; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 194..219; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins