PLPP5
entrez
84513
canonical
uniprot
Q8NEB5
canonical
ensembl
ENSG00000147535
resolver
ensp
ENSP00000390622
resolver
ensp
ENSP00000392553
resolver
ensp
ENSP00000414522
resolver
ensp
ENSP00000432122
resolver
ensp
ENSP00000434916
resolver
ensp
ENSP00000437248
resolver
ensp
ENSP00000648220
resolver
ensp
ENSP00000648224
resolver
ensp
ENSP00000648226
resolver
ensp
ENSP00000648228
resolver
ensp
ENSP00000691370
resolver
enst
ENST00000531823
resolver
genesymbol
PLPP5
resolver
genesymbol_syn
DPPL1
resolver
genesymbol_syn
HTPAP
resolver
genesymbol_syn
PPAPDC1B
resolver
hgnc
HGNC:25026
resolver
uniprot
A0A140VK38
resolver
uniprot
C9JKF5
resolver
uniprot
E9PNB1
resolver
uniprot
Q3KQX6
resolver
uniprot
Q9BY45
resolver
uniprot_entry
A0A140VK38_HUMAN
resolver
uniprot_entry
E9PNB1_HUMAN
resolver
uniprot_entry
PLPP5_HUMAN
resolver
uniprot_sec
C9JKF5
resolver
uniprot_sec
Q3KQX6
resolver
uniprot_sec
Q9BY45
resolver
activity_regulation
ACTIVITY REGULATION: Magnesium-independent phospholipid phosphatase (PubMed:17590538). Inhibited by N-ethylmaleimide (PubMed:17590538). {ECO:0000269|PubMed:17590538}.
uniprot
proteins
amino_acid_sequence
MGKAAAAVAFGAEVGVRLALFAAFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPPLTDAECHKPFQDKLVLSTAQKPGDSYCFDI
uniprot
proteins
ec_number
3.1.3.4
uniprot
proteins
ec_number
3.6.1.75
uniprot
proteins
function
FUNCTION: Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules (PubMed:17590538). {ECO:0000269|PubMed:17590538, ECO:0000303|PubMed:17590538}.
uniprot
proteins
mass_dalton
29484
uniprot
proteins
mutagenesis
MUTAGEN 115; /note="R->A: Loss of phosphatase activity; when associated with A-152 and with A-208."; /evidence="ECO:0000269|PubMed:17590538"; MUTAGEN 152; /note="H->A: Loss of phosphatase activity; when associated with A-115 and with A-208."; /evidence="ECO:0000269|PubMed:17590538"; MUTAGEN 208; /note="H->A: Loss of phosphatase activity; when associated with A-115 and with A-152."; /evidence="ECO:0000269|PubMed:17590538
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000269|PubMed:17590538}.
uniprot
proteins
protein_family
PA-phosphatase related phosphoesterase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16261160
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17590538
uniprot
proteins
sequence_length
264
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:17590538}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q3UMZ3}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 55..75; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 91..111; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 180..200; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 209..228; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins