Mims1
entrez
108654
canonical
uniprot
Q8BGY7
canonical
ensembl
ENSMUSG00000038121
resolver
ensp
ENSMUSP00000045927
resolver
ensp
ENSMUSP00000315683
resolver
enst
ENSMUST00000042852
resolver
genesymbol
Mims1
resolver
genesymbol_syn
Fam210a
resolver
uniprot
Q3TXD0
resolver
uniprot
Q8BNY5
resolver
uniprot_entry
MIMS1_MOUSE
resolver
uniprot_sec
Q3TXD0
resolver
uniprot_sec
Q8BNY5
resolver
amino_acid_sequence
MQWNVPRTMSRLALRTFVEAQKARLFDHHWRIKGPLLVHRGEYRVAWTPHLRKQWLHLSAVQCLAKQRNLLDAQPPQLGTLRQERWEQDILSKRVLSSSSTSQETPSEKKEETDPLQDKSISLYQRFKKTFRQYGKVLIPVHLITSGIWFGTFYYATIKGVNVIPFLEVIGLPDSIVDILKNSQSGNALTAYAMFKIATPARYTVTLGGTSFTVKYLRSHGYMSTPPPVKEYLQGRMEETKELITEKMEETKDRLTEKLQETKGKVSFKKKVE
uniprot
proteins
function
FUNCTION: Mitochondrial inner membrane protein essential for mitochondrial homeostasis, structural integrity, and cellular metabolism (PubMed:29618611, PubMed:37522353). Regulates mitochondrial translation by modulating protein synthesis of mitochondrial DNA-encoded genes (PubMed:37522353). Plays a critical role in skeletal muscle mass and strength by regulating mitochondrial density, function, and protein synthesis (PubMed:29618611, PubMed:31980842). In brown adipose tissue, regulates mitochondrial cristae remodeling in response to cold stress by interacting with mitochondrial protease YME1L1 and enhancing its proteolytic activity, promoting OMA1 degradation and regulating OPA1 processing (PubMed:37816711). Required for cardiac mitochondrial homeostasis and normal cardiomyocyte contractile function (PubMed:37522353). In skeletal muscle, positively regulates myoblast differentiation by enhancing expression of myogenic factors (PubMed:31980842). {ECO:0000269|PubMed:29618611, ECO:0000269|PubMed:31980842, ECO:0000269|PubMed:37522353, ECO:0000269|PubMed:37816711}.
uniprot
proteins
mass_dalton
31600
uniprot
proteins
protein_family
MIMS family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29618611
uniprot
proteins
pubmed
31980842
uniprot
proteins
pubmed
37522353
uniprot
proteins
pubmed
37816711
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:37816711, ECO:0000305|PubMed:29618611}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:29618611}.
uniprot
proteins
transmembrane_region
TRANSMEM 138..158; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins