Pla2g2f
entrez
26971
canonical
uniprot
Q9QZT4
canonical
ensembl
ENSMUSG00000028749
resolver
ensp
ENSMUSP00000030526
resolver
ensp
ENSMUSP00000320915
resolver
genesymbol
Pla2g2f
resolver
uniprot
Q8CE14
resolver
uniprot_entry
PA2GF_MOUSE
resolver
uniprot_sec
Q8CE14
resolver
amino_acid_sequence
MKKFFAIAVLAGSVVTTAHSSLLNLKSMVEAITHRNSILSFVGYGCYCGLGGRGHPMDEVDWCCHAHDCCYEKLFEQGCRPYVDHYDHRIENGTMIVCTELNETECDKQTCECDKSLTLCLKDHPYRNKYRGYFNVYCQGPTPNCSIYDPYPEEVTCGHGLPATPVST
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:10531313). Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids (phospholipase A2 activity), the catalytic efficiency decreasing in the following order: phosphatidylglycerols > phosphatidylethanolamines > phosphatidylcholines > phosphatidylserines (PubMed:10531313, PubMed:11877435). May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (PubMed:10531313). {ECO:0000269|PubMed:10531313, ECO:0000269|PubMed:11877435}.
uniprot
proteins
mass_dalton
18880
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="G->S: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:11877435"; MUTAGEN 157; /note="C->S: No effect on lipase activity toward 1-palmitoyl-2-arachidonoyl-phosphatidylethanolamine (2-AA-PE)."; /evidence="ECO:0000269|PubMed:11877435
uniprot
proteins
protein_family
Phospholipase A2 family
uniprot
proteins
pubmed
10531313
uniprot
proteins
pubmed
11877435
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11877435}. Cell membrane; Peripheral membrane protein {ECO:0000269|PubMed:11877435}.
uniprot
proteins