Acvr1c
entrez
269275
canonical
uniprot
Q8K348
canonical
ensembl
ENSMUSG00000026834
resolver
ensp
ENSMUSP00000028178
resolver
ensp
ENSMUSP00000097663
resolver
ensp
ENSMUSP00000108227
resolver
enst
ENSMUST00000028178
resolver
enst
ENSMUST00000100085
resolver
enst
ENSMUST00000112608
resolver
genesymbol
Acvr1c
resolver
genesymbol_syn
Alk7
resolver
uniprot
A2AJR4
resolver
uniprot
A2AJR5
resolver
uniprot
F7A6T8
resolver
uniprot
Q3V348
resolver
uniprot_entry
A2AJR5_MOUSE
resolver
uniprot_entry
ACV1C_MOUSE
resolver
uniprot_entry
F7A6T8_MOUSE
resolver
uniprot_entry
Q3V348_MOUSE
resolver
uniprot_sec
A2AJR4
resolver
amino_acid_sequence
MTPARGSALSLALLLVALAADLAAGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPRLGPTELTVVITVPVCLLSIAAMLTIWACQDRQCTYRKTKRHNVEEALAEYSLVNAGKTLKDLIYDATASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPEMLDDTMNLSIFESFKRADIYSVGLVYWEIARRCSVGGVVEEYQLPYYDMVPSDPSIEEMRKVVCDQKLRPNLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVKEDCKA
uniprot
proteins
ec_number
2.7.11.30
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells (PubMed:18480258, PubMed:36403856). Acts as a positive regulator for macrophage activation partially through down-regulation of PPARG expression (PubMed:32641645). {ECO:0000250|UniProtKB:P70539, ECO:0000250|UniProtKB:Q8NER5, ECO:0000269|PubMed:18480258, ECO:0000269|PubMed:32641645, ECO:0000269|PubMed:36403856}.
uniprot
proteins
mass_dalton
54700
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TGFB receptor subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
15485907
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18480258
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
32641645
uniprot
proteins
pubmed
36403856
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32641645}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins