Arfip1
entrez
99889
canonical
uniprot
G5E8V9
canonical
ensembl
ENSMUSG00000074513
resolver
ensembl
ENSMUSG00000102805
resolver
ensp
ENSMUSP00000096588
resolver
ensp
ENSMUSP00000116393
resolver
ensp
ENSMUSP00000122964
resolver
ensp
ENSMUSP00000322740
resolver
ensp
ENSMUSP00000322748
resolver
genesymbol
Arfip1
resolver
uniprot
A2RSX9
resolver
uniprot
E9Q3G5
resolver
uniprot_entry
ARFP1_MOUSE
resolver
uniprot_sec
A2RSX9
resolver
uniprot_sec
E9Q3G5
resolver
amino_acid_sequence
MAQESPKNSAAEIPVTSNGEVDDAHEHGYNRDLKHSLPSGLGLSETQITSHGFDSTKEGVTEAGAPQGSSAPPLPCVLSPSRVAASKLTQQAGDLTVPAGGQRTHTKGGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQKQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYENARVEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQIHKEKYDKMRSDVSVKLKFLEENKVKVLRNQLVLFHSAVAAYFAGNQKQLELTLKQFHVRLKTPGVDAPSWLEEQ
uniprot
proteins
function
FUNCTION: Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells. {ECO:0000250|UniProtKB:P53367}.
uniprot
proteins
mass_dalton
41518
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKD1; phosphorylation delocalizes ARFIP1 from the Golgi and disrupts its ability to inhibit the activity of ADP-ribosylation factor, an important component of the vesicle scission machinery. {ECO:0000250|UniProtKB:P53367}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:P53367}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P53367}.
uniprot
proteins