ATP10D
entrez
57205
canonical
uniprot
Q9P241
canonical
ensembl
ENSG00000145246
resolver
ensp
ENSP00000273859
resolver
genesymbol
ATP10D
resolver
genesymbol_syn
ATPVD
resolver
genesymbol_syn
KIAA1487
resolver
hgnc
HGNC:13549
resolver
uniprot
A2RRC8
resolver
uniprot
D6REN2
resolver
uniprot
Q8NC70
resolver
uniprot
Q96SR3
resolver
uniprot_entry
AT10D_HUMAN
resolver
uniprot_sec
A2RRC8
resolver
uniprot_sec
D6REN2
resolver
uniprot_sec
Q8NC70
resolver
uniprot_sec
Q96SR3
resolver
amino_acid_sequence
MTEALQWARYHWRRLIRGATRDDDSGPYNYSSLLACGRKSSQTPKLSGRHRIVVPHIQPFKDEYEKFSGAYVNNRIRTTKYTLLNFVPRNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDRCWKDVTVGDFIRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFSSRIECESPNNDLSRFRGFLEHSNKERVGLSKENLLLRGCTIRNTEAVVGIVVYAGHETKAMLNNSGPRYKRSKLERRANTDVLWCVMLLVIMCLTGAVGHGIWLSRYEKMHFFNVPEPDGHIISPLLAGFYMFWTMIILLQVLIPISLYVSIEIVKLGQIYFIQSDVDFYNEKMDSIVQCRALNIAEDLGQIQYLFSDKTGTLTENKMVFRRCSVAGFDYCHEENARRLESYQEAVSEDEDFIDTVSGSLSNMAKPRAPSCRTVHNGPLGNKPSNHLAGSSFTLGSGEGASEVPHSRQAAFSSPIETDVVPDTRLLDKFSQITPRLFMPLDETIQNPPMETLYIIDFFIALAICNTVVVSAPNQPRQKIRHPSLGGLPIKSLEEIKSLFQRWSVRRSSSPSLNSGKEPSSGVPNAFVSRLPLFSRMKPASPVEEEVSQVCESPQCSSSSACCTETEKQHGDAGLLNGKAESLPGQPLACNLCYEAESPDEAALVYAARAYQCTLRSRTPEQVMVDFAALGPLTFQLLHILPFDSVRKRMSVVVRHPLSNQVVVYTKGADSVIMELLSVASPDGASLEKQQMIVREKTQKHLDDYAKQGLRTLCIAKKVMSDTEYAEWLRNHFLAETSIDNREELLLESAMRLENKLTLLGATGIEDRLQEGVPESIEALHKAGIKIWMLTGDKQETAVNIAYACKLLEPDDKLFILNTQSKDACGMLMSTILKELQKKTQALPEQVSLSEDLLQPPVPRDSGLRAGLIITGKTLEFALQESLQKQFLELTSWCQAVVCCRATPLQKSEVVKLVRSHLQVMTLAIGDGANDVSMIQVADIGIGVSGQEGMQAVMASDFAVSQFKHLSKLLLVHGHWCYTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGTSMTDYWVLIFFNLLFTSAPPVIYGVLEKDVSAETLMQLPELYRSGQKSEAYLPHTFWITLLDAFYQSLVCFFVPYFTYQGSDTDIFAFGNPLNTAALFIVLLHLVIESKSLTWIHLLVIIGSILSYFLFAIVFGAMCVTCNPPSNPYWIMQEHMLDPVFYLVCILTTSIALLPRFVYRVLQGSLFPSPILRAKHFDRLTPEERTKALKKWRGAGKMNQVTSKYANQSAGKSGRRPMPGPSAVFAMKSASSCAIEQGNLSLCETALDQGYSETKAFEMAGPSKGKES
uniprot
proteins
ec_number
7.6.2.1
uniprot
proteins
function
FUNCTION: Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane. {ECO:0000269|PubMed:30530492}.
uniprot
proteins
mass_dalton
160274
uniprot
proteins
mutagenesis
MUTAGEN 110..111; /note="NW->QA: Impairs ATPase flippase activity."; /evidence="ECO:0000269|PubMed:30530492"; MUTAGEN 215; /note="E->Q: Impairs ATPase flippase activity."; /evidence="ECO:0000269|PubMed:30530492"; MUTAGEN 381; /note="Q->N: Impairs ATPase flippase activity."; /evidence="ECO:0000269|PubMed:30530492"; MUTAGEN 382; /note="V->T: Increases ATPase flippase activity."; /evidence="ECO:0000269|PubMed:30530492"; MUTAGEN 1148..1149; /note="LI->IT: Impairs ATPase flippase activity."; /evidence="ECO:0000269|PubMed:30530492
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated at the conserved aspartate of the P-type ATPase signature sequence. {ECO:0000250|UniProtKB:O94823}.
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IV subfamily
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
12532265
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
21914794
uniprot
proteins
pubmed
25947375
uniprot
proteins
pubmed
30530492
uniprot
proteins
sequence_length
1426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:30530492}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25947375}; Multi-pass membrane protein {ECO:0000255}. Note=Exit from the endoplasmic reticulum requires the presence of CDC50A, but not that of CDC50B. {ECO:0000269|PubMed:25947375}.
uniprot
proteins
transmembrane_region
TRANSMEM 98..118; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 122..142; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 322..342; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 366..386; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1114..1134; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1146..1166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1196..1216; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1225..1245; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1253..1273; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1293..1313; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins