ADAM30
entrez
11085
canonical
uniprot
Q9UKF2
canonical
ensembl
ENSG00000134249
resolver
ensp
ENSP00000358407
resolver
genesymbol
ADAM30
resolver
hgnc
HGNC:208
resolver
uniprot
A8K8W8
resolver
uniprot
Q5T3X6
resolver
uniprot
Q8TBZ7
resolver
uniprot
Q9UKF1
resolver
uniprot_entry
ADA30_HUMAN
resolver
uniprot_entry
Q8TBZ7_HUMAN
resolver
uniprot_sec
A8K8W8
resolver
uniprot_sec
Q5T3X6
resolver
uniprot_sec
Q9UKF1
resolver
amino_acid_sequence
MRSVQIFLSQCRLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNCIMGSGRTGFSNCSYISFFKHISSGATCLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLKPKQEKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIESKRPKAKSVKKQKK
uniprot
proteins
ec_number
3.4.24.-
uniprot
proteins
function
FUNCTION: Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034). {ECO:0000269|PubMed:27333034}.
uniprot
proteins
mass_dalton
88940
uniprot
proteins
mutagenesis
MUTAGEN 338; /note="H->L: Loss of enzymatic activity; when associated with L-342 and L-348."; /evidence="ECO:0000269|PubMed:27333034"; MUTAGEN 342; /note="H->L: Loss of enzymatic activity; when associated with L-338 and L-348."; /evidence="ECO:0000269|PubMed:27333034"; MUTAGEN 348; /note="H->L: Loss of enzymatic activity; when associated with L-338 and L-342."; /evidence="ECO:0000269|PubMed:27333034
uniprot
proteins
pubmed
10512762
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
27333034
uniprot
proteins
sequence_length
790
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:27333034}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 688..708; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins