Mapk8ip1
entrez
19099
canonical
uniprot
Q9WVI9
canonical
ensembl
ENSMUSG00000027223
resolver
ensp
ENSMUSP00000050773
resolver
ensp
ENSMUSP00000106910
resolver
genesymbol
Mapk8ip1
resolver
genesymbol_syn
Ib1
resolver
genesymbol_syn
Jip1
resolver
genesymbol_syn
Mapk8ip
resolver
genesymbol_syn
Prkm8ip
resolver
uniprot
O35145
resolver
uniprot
Q3UI81
resolver
uniprot
Q6GQW8
resolver
uniprot
Q925J8
resolver
uniprot
Q9R1H9
resolver
uniprot
Q9R1Z1
resolver
uniprot
Q9WVI7
resolver
uniprot
Q9WVI8
resolver
uniprot_entry
JIP1_MOUSE
resolver
uniprot_entry
Q3UI81_MOUSE
resolver
uniprot_entry
Q6GQW8_MOUSE
resolver
uniprot_sec
O35145
resolver
uniprot_sec
Q925J8
resolver
uniprot_sec
Q9R1H9
resolver
uniprot_sec
Q9R1Z1
resolver
uniprot_sec
Q9WVI7
resolver
uniprot_sec
Q9WVI8
resolver
amino_acid_sequence
MAERESGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRPPRAGLLSAGSSGSAGSRLQAEMLQMDLIDAAGDTPGAEDDEEEEDDELAAQRPGVGPPKAESNQDPAPRSQGQGPGTGSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQGSPVPTQDRGTSTDSPCRRSAATQMAPPSGPPATAPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDPAEPTSTFMPPTESRMSVSSDPDPAAYSVTAGRPHPSISEEDEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASASSPYESAIGEEYEEAPQPRPPTCLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCVINGEEHEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWIDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDALEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE
uniprot
proteins
function
FUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response (By similarity). Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells (PubMed:23963642). {ECO:0000250, ECO:0000269|PubMed:11562351, ECO:0000269|PubMed:23963642}.
uniprot
proteins
mass_dalton
77282
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK8, MAPK9 and MAPK10. Phosphorylation on Thr-103 is also necessary for the dissociation and activation of MAP3K12. Phosphorylated by VRK2. Hyperphosphorylated during mitosis following activation of stress-activated and MAP kinases (By similarity). {ECO:0000250}.; PTM: Ubiquitinated. Two preliminary events are required to prime for ubiquitination; phosphorylation and an increased in intracellular calcium concentration. Then, the calcium influx initiates ubiquitination and degradation by the ubiquitin-proteasome pathway.
uniprot
proteins
protein_family
JIP scaffold family
uniprot
proteins
pubmed
10098834
uniprot
proteins
pubmed
10490659
uniprot
proteins
pubmed
10574993
uniprot
proteins
pubmed
10712642
uniprot
proteins
pubmed
10827173
uniprot
proteins
pubmed
11238452
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
11562351
uniprot
proteins
pubmed
11912189
uniprot
proteins
pubmed
16628014
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23963642
uniprot
proteins
pubmed
27084103
uniprot
proteins
pubmed
9235893
uniprot
proteins
sequence_length
707
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Mitochondrion membrane {ECO:0000250}. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity). {ECO:0000250}.
uniprot
proteins