Cblc
entrez
292699
canonical
uniprot
G3V8H4
canonical
ensembl
ENSRNOG00000018953
resolver
ensembl
ENSRNOG00060032969
resolver
ensembl
ENSRNOG00065033207
resolver
ensp
ENSRNOP00000025829
resolver
ensp
ENSRNOP00060047268
resolver
ensp
ENSRNOP00065047004
resolver
enst
ENSRNOT00000025829
resolver
enst
ENSRNOT00060057189
resolver
enst
ENSRNOT00065057110
resolver
genesymbol
Cblc
resolver
genesymbol_syn
Cbl-3
resolver
uniprot
Q3KRC9
resolver
uniprot_entry
CBLC_RAT
resolver
uniprot_sec
Q3KRC9
resolver
activity_regulation
ACTIVITY REGULATION: Phosphorylation at Tyr-341 is necessary and sufficient for the activation of E3 activity. {ECO:0000250|UniProtKB:Q9ULV8}.
uniprot
proteins
amino_acid_sequence
MAAATAPQGWQWGEPRALGRAVKLLQRLEEQCRDLRLFVGPPSLRDLLPRTAQLLREVAKARSDKTRGDPEGPGGAGDFLVIYLTNLEAKGRQVAELLPHRGKKDANQDVFPEGSRFRRQLAKLALIFSHMHAELSALFPEGKYCGHLYQITKGSANTFWRENCGVRCVLPWAEFQSLLCSCHPVEPGPIMQALRSTLDLTCSGHVSVFEFDIFTRLFQPWPTLLKNWQLLAVNHPGYMAFLTYDEVQTRLQAYRDKPGSYIFRPSCTRLGQWAIGYVSSNGSILQTIPLNKPLLQVLLKGQKDGIFLYPDGKNHNPDLTELCRAVLNQCIQVSQEQLQLYQAMNSTFELCKICTERDKDVRIEPCGHLLCSCCLAAWQHSDSQTCPFCRCEIKGREAVSICQAQERSMEVRTTAGDSGDNCHQEAAEWKLESVTPSAPPLPPEVPCPQRPQNKGWLTLAPFTLPRLRPPLPLPKMASVLWEVTSRPQVREGATESS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419', has the highest ubiquitin ligase activity among CBL family proteins. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. {ECO:0000269|PubMed:18753381}.
uniprot
proteins
mass_dalton
55775
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on multiple tyrosine residues by SRC. {ECO:0000250}.; PTM: Autoubiquitinated, when phosphorylated at Tyr-341.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18753381
uniprot
proteins
sequence_length
497
uniprot
proteins