Cntd1
entrez
68107
canonical
uniprot
Q9D995
canonical
ensembl
ENSMUSG00000078653
resolver
ensp
ENSMUSP00000099396
resolver
genesymbol
Cntd1
resolver
genesymbol_syn
Cntd
resolver
uniprot
Q9D9L8
resolver
uniprot_entry
CNTD1_MOUSE
resolver
uniprot_sec
Q9D9L8
resolver
amino_acid_sequence
MNMEGPLRPRLVNCSDFQFGVVTTETIENALLHLAQQNEQAVKEAAGRTGSFRETRIVEFVFLLSEQWCLEKSVSYQAVEILERFMLKQAEDICRQATLQLRGKDTELQSWRAMKEQLVNKFILRLVSCVQLASKLSFHYKIVSNITVLNFLQALGYVHTKEELLESELDILKSLNFQINLPTPLAYVEMLLEVLGYNGCLVPATQLHATCLTLLDLVYLLHEPIYESLLRASIENSTPSQLQGEKFLSVKEDFMLLAVGIIAASAFIQNHECWSQVIGHLQSITGIASESIAEFSYAILTHSVGANTPGPQQPVPHKAARALRTAAAAASSNT
uniprot
proteins
function
FUNCTION: Plays a role in the different steps of crossover formation during meiotic recombination (PubMed:24891606, PubMed:32555348, PubMed:32640224). Participates in the crossover differentiation step of crossover-specific recombination intermediates through its interaction with PRR19 (PubMed:32555348). In addition, stimulates crossover formation through the interactions with RFC3 and RFC4 and simultaneously regulates cell-cycle progression through interactions with CDC34 and subsequent ubiquitination of WEE1 (PubMed:32640224). May also participates in an active deselection process that destabilizes or removes excess pre-CO intermediates (PubMed:24891606). {ECO:0000269|PubMed:24891606, ECO:0000269|PubMed:32555348, ECO:0000269|PubMed:32640224}.
uniprot
proteins
mass_dalton
37222
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24891606
uniprot
proteins
pubmed
32555348
uniprot
proteins
pubmed
32640224
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32640224}. Cytoplasm {ECO:0000269|PubMed:32640224}. Chromosome {ECO:0000269|PubMed:32555348}. Note=Shuttles between the nucleus and cytoplasm in a stage-specific manner of prophase I cells (PubMed:32640224). Co-localized at crossover sites with PRR19 (PubMed:32555348). {ECO:0000269|PubMed:32555348, ECO:0000269|PubMed:32640224}.
uniprot
proteins