KCNMB2
entrez
10242
canonical
uniprot
Q9Y691
canonical
ensembl
ENSG00000197584
resolver
ensembl
ENSG00000275163
resolver
ensp
ENSP00000351068
resolver
ensp
ENSP00000397483
resolver
ensp
ENSP00000407592
resolver
ensp
ENSP00000408252
resolver
ensp
ENSP00000483415
resolver
ensp
ENSP00000564597
resolver
enst
ENST00000358316
resolver
enst
ENST00000420517
resolver
enst
ENST00000432997
resolver
enst
ENST00000452583
resolver
enst
ENST00000614557
resolver
enst
ENST00000894538
resolver
genesymbol
KCNMB2
resolver
hgnc
HGNC:6286
resolver
uniprot
B5BNW5
resolver
uniprot
B7Z513
resolver
uniprot_entry
B5BNW5_HUMAN
resolver
uniprot_entry
B7Z513_HUMAN
resolver
uniprot_entry
KCMB2_HUMAN
resolver
amino_acid_sequence
MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMVCSIMMYFLLGITLLRSYMQSVWTEESQCTLLNASITETFNCSFSCGPDCWKLSQYPCLQVYVNLTSSGEKLLLYHTEETIKINQKCSYIPKCGKNFEESMSLVNVVMENFRKYQHFSCYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRINR
uniprot
proteins
function
FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. {ECO:0000269|PubMed:10097176, ECO:0000269|PubMed:10377337}.
uniprot
proteins
mass_dalton
27130
uniprot
proteins
mutagenesis
MUTAGEN 2..4; /note="FIW->GGG: Abolishes inactivation of KCNMA1 channel."; /evidence="ECO:0000269|PubMed:12566540
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10792058}.
uniprot
proteins
protein_family
KCNMB (TC 8.A.14.1) family
uniprot
proteins
protein_family
KCNMB2 subfamily
uniprot
proteins
pubmed
10097176
uniprot
proteins
pubmed
10377337
uniprot
proteins
pubmed
10692449
uniprot
proteins
pubmed
10792058
uniprot
proteins
pubmed
11517232
uniprot
proteins
pubmed
12136044
uniprot
proteins
pubmed
12566540
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 47..67; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 195..215; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins