NAIP
entrez
4671
canonical
uniprot
Q13075
canonical
ensembl
ENSG00000249437
resolver
ensembl
ENSG00000276068
resolver
ensembl
ENSG00000278613
resolver
ensp
ENSP00000428363
resolver
ensp
ENSP00000428657
resolver
ensp
ENSP00000443944
resolver
ensp
ENSP00000477938
resolver
ensp
ENSP00000479075
resolver
ensp
ENSP00000481094
resolver
ensp
ENSP00000483012
resolver
ensp
ENSP00000484107
resolver
ensp
ENSP00000484731
resolver
ensp
ENSP00000484845
resolver
ensp
ENSP00000487347
resolver
enst
ENST00000610590
resolver
enst
ENST00000612328
resolver
enst
ENST00000615009
resolver
enst
ENST00000616766
resolver
enst
ENST00000618877
resolver
enst
ENST00000619206
resolver
enst
ENST00000620988
resolver
enst
ENST00000625431
resolver
genesymbol
NAIP
resolver
genesymbol_syn
BIRC1
resolver
hgnc
HGNC:7634
resolver
uniprot
A0A0G2JNC7
resolver
uniprot
A0A0G2JP68
resolver
uniprot
A0A0G2JS53
resolver
uniprot
B7ZLE8
resolver
uniprot
B9EG72
resolver
uniprot
E9PHD1
resolver
uniprot
O75857
resolver
uniprot
Q13730
resolver
uniprot
Q59GI6
resolver
uniprot
Q8TDZ4
resolver
uniprot
Q99796
resolver
uniprot_entry
A0A0G2JNC7_HUMAN
resolver
uniprot_entry
A0A0G2JP68_HUMAN
resolver
uniprot_entry
A0A0G2JS53_HUMAN
resolver
uniprot_entry
B7ZLE8_HUMAN
resolver
uniprot_entry
BIRC1_HUMAN
resolver
uniprot_sec
B9EG72
resolver
uniprot_sec
E9PHD1
resolver
uniprot_sec
O75857
resolver
uniprot_sec
Q13730
resolver
uniprot_sec
Q59GI6
resolver
uniprot_sec
Q8TDZ4
resolver
uniprot_sec
Q99796
resolver
amino_acid_sequence
MATQQKASDERISQFDHNLLPELSALLGLDAVQLAKELEEEEQKERAKMQKGYNSQMRSEAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKRFHPDCGFLLNKDVGNIAKYDIRVKNLKSRLRGGKMRYQEEEARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWFQEAKNLNEQLRAAYTSASFRHMSLLDISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVRTNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVSEHLLVLALKTAYQSNTVAACSPFVLQFLQGRTLTLGALNLQYFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKKLTEIKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK
uniprot
proteins
function
FUNCTION: Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.; FUNCTION: Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.
uniprot
proteins
mass_dalton
159582
uniprot
proteins
mutagenesis
MUTAGEN 476; /note="K->T: Prevents the proper cleavage of pro-CASP9, but does not inhibit the cleavage of pro-CASP3 by CASP9."; /evidence="ECO:0000269|PubMed:21371431
uniprot
proteins
pubmed
11896143
uniprot
proteins
pubmed
11955612
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18414036
uniprot
proteins
pubmed
19923725
uniprot
proteins
pubmed
21371431
uniprot
proteins
pubmed
21918512
uniprot
proteins
pubmed
22504023
uniprot
proteins
pubmed
7552146
uniprot
proteins
pubmed
7813013
uniprot
proteins
pubmed
8552191
uniprot
proteins
pubmed
9503025
uniprot
proteins
sequence_length
1403
uniprot
proteins