DOK4
entrez
55715
canonical
uniprot
Q8TEW6
canonical
ensembl
ENSG00000125170
resolver
ensp
ENSP00000344277
resolver
ensp
ENSP00000455128
resolver
ensp
ENSP00000455566
resolver
ensp
ENSP00000550450
resolver
ensp
ENSP00000550451
resolver
ensp
ENSP00000550452
resolver
ensp
ENSP00000550453
resolver
ensp
ENSP00000550454
resolver
ensp
ENSP00000550456
resolver
ensp
ENSP00000550461
resolver
ensp
ENSP00000550462
resolver
ensp
ENSP00000550463
resolver
ensp
ENSP00000550464
resolver
ensp
ENSP00000550465
resolver
ensp
ENSP00000642105
resolver
ensp
ENSP00000642106
resolver
ensp
ENSP00000642107
resolver
enst
ENST00000340099
resolver
enst
ENST00000566936
resolver
enst
ENST00000569548
resolver
enst
ENST00000880391
resolver
enst
ENST00000880392
resolver
enst
ENST00000880393
resolver
enst
ENST00000880394
resolver
enst
ENST00000880395
resolver
enst
ENST00000880397
resolver
enst
ENST00000880402
resolver
enst
ENST00000880403
resolver
enst
ENST00000880404
resolver
enst
ENST00000880405
resolver
enst
ENST00000880406
resolver
enst
ENST00000972046
resolver
enst
ENST00000972047
resolver
enst
ENST00000972048
resolver
genesymbol
DOK4
resolver
hgnc
HGNC:19868
resolver
uniprot
H3BQ19
resolver
uniprot
O75209
resolver
uniprot
Q9BTP2
resolver
uniprot
Q9NVV3
resolver
uniprot_entry
DOK4_HUMAN
resolver
uniprot_entry
H3BQ19_HUMAN
resolver
uniprot_sec
O75209
resolver
uniprot_sec
Q9BTP2
resolver
uniprot_sec
Q9NVV3
resolver
amino_acid_sequence
MATNFSDIVKQGYVKMKSRKLGIYRRCWLVFRKSSSKGPQRLEKYPDEKSVCLRGCPKVTEISNVKCVTRLPKETKRQAVAIIFTDDSARTFTCDSELEAEEWYKTLSVECLGSRLNDISLGEPDLLAPGVQCEQTDRFNVFLLPCPNLDVYGECKLQITHENIYLWDIHNPRVKLVSWPLCSLRRYGRDATRFTFEAGRMCDAGEGLYTFQTQEGEQIYQRVHSATLAIAEQHKRVLLEMEKNVRLLNKGTEHYSYPCTPTTMLPRSAYWHHITGSQNIAEASSYAGEGYGAAQASSETDLLNRFILLKPKPSQGDSSEAKTPSQ
uniprot
proteins
function
FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. {ECO:0000250}.
uniprot
proteins
mass_dalton
37028
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation. {ECO:0000269|PubMed:12730241}.
uniprot
proteins
protein_family
DOK family
uniprot
proteins
protein_family
Type B subfamily
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
12595900
uniprot
proteins
pubmed
12730241
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
326
uniprot
proteins