Pomc
entrez
18976
canonical
uniprot
P01193
canonical
ensembl
ENSMUSG00000020660
resolver
ensp
ENSMUSP00000020990
resolver
ensp
ENSMUSP00000151367
resolver
ensp
ENSMUSP00000151504
resolver
enst
ENSMUST00000020990
resolver
enst
ENSMUST00000218089
resolver
enst
ENSMUST00000219543
resolver
genesymbol
Pomc
resolver
genesymbol_syn
Pomc1
resolver
uniprot
P01200
resolver
uniprot
Q544U4
resolver
uniprot_entry
COLI_MOUSE
resolver
uniprot_sec
P01200
resolver
uniprot_sec
Q544U4
resolver
amino_acid_sequence
MPRFCYSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLLACIRACKLDLSLETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGPRNSSSAGSAAQRRAEEEAVWGDGSPEPSPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPLEFKRELEGERPLGLEQVLESDAEKDDGPYRVEHFRWSNPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ
uniprot
proteins
function
FUNCTION: Precursor protein of pituitary hormones that are involved in diverse physiological processes, including the regulation of energy balance, stress response, immune function and skin pigmentation. {ECO:0000250|UniProtKB:P01189}.; FUNCTION: [Corticotropin]: Functions as a ligand for the melanocortin receptors MC1R, MC2R, MC3R and MC5R (PubMed:9413988). Activation of MC1R increases melanogenesis in melanocytes found in the skin and hair. Binding to MC2R stimulates the adrenal glands to secrete cortisol. Contributes to the regulation of energy homeostasis through activation of MC3R (By similarity). Involved in the regulation exocrine gland function through MC5R activation (PubMed:9413988). {ECO:0000250|UniProtKB:P01189, ECO:0000269|PubMed:9413988}.; FUNCTION: [Melanocyte-stimulating hormone alpha]: Serves as a ligand for the melanocortin receptors MC1R, MC3R, MC4R and MC5R (PubMed:35926007, PubMed:9413988). Activation of MC1R promotes melanogenesis in melanocytes of the skin and hair. Contributes to the regulation of energy homeostasis through activation of MC3R. Through MC4R activation, functions as an anorexigenic peptide (By similarity). Promotes immunosuppression and involved in the regulation exocrine gland function through MC5R activation (PubMed:35926007, PubMed:9413988). {ECO:0000250|UniProtKB:P01189, ECO:0000269|PubMed:35926007, ECO:0000269|PubMed:9413988}.; FUNCTION: [Beta-endorphin]: Endogenous orexigenic opiate.; FUNCTION: [Met-enkephalin]: Endogenous opiate.
uniprot
proteins
mass_dalton
26707
uniprot
proteins
post_translational_modification
PTM: Specific enzymatic cleavages at paired basic residues yield the different active peptides.
uniprot
proteins
protein_family
POMC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1689057
uniprot
proteins
pubmed
221916
uniprot
proteins
pubmed
2536749
uniprot
proteins
pubmed
25707796
uniprot
proteins
pubmed
35926007
uniprot
proteins
pubmed
6303853
uniprot
proteins
pubmed
6308009
uniprot
proteins
pubmed
9413988
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25707796}. Note=Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms. {ECO:0000269|PubMed:25707796}.
uniprot
proteins