Dxo
entrez
361799
canonical
uniprot
Q6MG77
canonical
ensembl
ENSRNOG00000000422
resolver
ensembl
ENSRNOG00055008620
resolver
ensembl
ENSRNOG00060004355
resolver
ensembl
ENSRNOG00065025955
resolver
ensp
ENSRNOP00000000483
resolver
ensp
ENSRNOP00055011622
resolver
ensp
ENSRNOP00060005558
resolver
ensp
ENSRNOP00065036641
resolver
enst
ENSRNOT00000000483
resolver
enst
ENSRNOT00055014551
resolver
enst
ENSRNOT00060007326
resolver
enst
ENSRNOT00065044745
resolver
genesymbol
Dxo
resolver
genesymbol_syn
Dom3z
resolver
uniprot_entry
DXO_RAT
resolver
amino_acid_sequence
MEPRGTKRKAEKTEVAKTWNKLPRSLPSLRTQPSLYSGPFPFYRRPSELGCFSLDAQRQYHGDARALRYYSPPPINGPGPDFDLRDGYPDRYQPRDEEVRERLDHLLRWVLEHRNQLEGGPGWLAGATVTWRGHLTKLLTTPYERQEGWQLAASRFQGTLYLSEVETPAARAQRLARPPLLRELMYMGYKFEQYMCADKPGGSPDPSGEVNTNVAFCSVLRSRLGNHPLLFSGEVDCLNPQAPCTQPPSCYVELKTSKEMHSPGQWRSFYRHKLLKWWAQSFLPGVPYVVAGFRNPEGFVCSLKTFPTMEMFENVRNDQEGWNPSVCMNFCAAFLSFAQSTVVQDDPRLVHLFSWEPGGPVTVSVHRDAPYAFLPSWYVEAMTQDLPSLSKTPSPKD
uniprot
proteins
ec_number
3.1.13.-
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
function
FUNCTION: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Preferentially acts on NAD-capped transcripts in response to environmental stress (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation. Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). In contrast to canonical decapping enzymes DCP2 and NUDT16, which cleave the cap within the triphosphate linkage, the decapping activity releases the entire cap structure GpppN and a 5'-end monophosphate RNA. Also has 5'-3' exoribonuclease activities: The 5'-end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity). Exhibits decapping activity towards FAD-capped RNAs (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity). {ECO:0000250|UniProtKB:O70348, ECO:0000250|UniProtKB:O77932}.
uniprot
proteins
mass_dalton
45299
uniprot
proteins
protein_family
DXO/Dom3Z family
uniprot
proteins
pubmed
15060004
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O77932}.
uniprot
proteins