TGIF2
entrez
60436
canonical
uniprot
Q9GZN2
canonical
ensembl
ENSG00000118707
resolver
ensembl
ENSG00000259399
resolver
ensp
ENSP00000362979
resolver
ensp
ENSP00000362981
resolver
ensp
ENSP00000481787
resolver
ensp
ENSP00000544738
resolver
genesymbol
TGIF2
resolver
hgnc
HGNC:15764
resolver
uniprot
B2R9U3
resolver
uniprot
E1P5T9
resolver
uniprot
H0YNI0
resolver
uniprot_entry
TGIF2_HUMAN
resolver
uniprot_sec
B2R9U3
resolver
uniprot_sec
E1P5T9
resolver
uniprot_sec
H0YNI0
resolver
amino_acid_sequence
MSDSDLGEDEGLLSLAGKRKRRGNLPKESVKILRDWLYLHRYNAYPSEQEKLSLSGQTNLSVLQICNWFINARRRLLPDMLRKDGKDPNQFTISRRGGKASDVALPRGSSPSVLAVSVPAPTNVLSLSVCSMPLHSGQGEKPAAPFPRGELESPKPLVTPGSTLTLLTRAEAGSPTGGLFNTPPPTPPEQDKEDFSSFQLLVEVALQRAAEMELQKQQDPSLPLLHTPIPLVSENPQ
uniprot
proteins
function
FUNCTION: Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. {ECO:0000269|PubMed:11427533}.
uniprot
proteins
mass_dalton
25878
uniprot
proteins
mutagenesis
MUTAGEN 182; /note="T->V: Decrease of phosphorylation. Strong decrease of phosphorylation; when associated with V-186."; /evidence="ECO:0000269|PubMed:11427533"; MUTAGEN 186; /note="T->V: Decrease of phosphorylation. Strong decrease of phosphorylation; when associated with V-182."; /evidence="ECO:0000269|PubMed:11427533
uniprot
proteins
post_translational_modification
PTM: The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway. {ECO:0000269|PubMed:11427533}.
uniprot
proteins
protein_family
TALE/TGIF homeobox family
uniprot
proteins
pubmed
11006116
uniprot
proteins
pubmed
11427533
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Note=Excluded from nucleoli.
uniprot
proteins