Eloc
entrez
64525
canonical
uniprot
P83941
canonical
ensembl
ENSRNOG00000076409
resolver
ensembl
ENSRNOG00055011110
resolver
ensembl
ENSRNOG00055017460
resolver
ensembl
ENSRNOG00060002027
resolver
ensembl
ENSRNOG00060021216
resolver
ensembl
ENSRNOG00065010662
resolver
ensp
ENSRNOP00000101569
resolver
ensp
ENSRNOP00055015190
resolver
ensp
ENSRNOP00055023736
resolver
ensp
ENSRNOP00060002166
resolver
ensp
ENSRNOP00060030217
resolver
ensp
ENSRNOP00065013203
resolver
enst
ENSRNOT00000140131
resolver
enst
ENSRNOT00055018831
resolver
enst
ENSRNOT00055029546
resolver
enst
ENSRNOT00060003184
resolver
enst
ENSRNOT00060036706
resolver
enst
ENSRNOT00065017256
resolver
genesymbol
Eloc
resolver
genesymbol_syn
Tceb1
resolver
uniprot
Q63182
resolver
uniprot_entry
ELOC_RAT
resolver
uniprot_sec
Q63182
resolver
amino_acid_sequence
MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
uniprot
proteins
function
FUNCTION: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). {ECO:0000250|UniProtKB:P83940, ECO:0000250|UniProtKB:Q15369}.; FUNCTION: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. Component the von Hippel-Lindau ubiquitination complex CBC(VHL). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The ECS(ASB9) complex mediates ubiquitination and degradation of CKB. As part of a multisubunit ubiquitin ligase complex, polyubiquitinates monoubiquitinated POLR2A (By similarity). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (By similarity). The ECS(ASB7) complex acts a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1 (By similarity). As part of the ECS(LRRC58) complex, mediates CDO1 ubiquitination and degradation, regulating cysteine catabolism (By similarity). {ECO:0000250|UniProtKB:P83940, ECO:0000250|UniProtKB:Q15369}.
uniprot
proteins
mass_dalton
12473
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q15369}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the DCX(AMBRA1) complex, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:Q15369}.
uniprot
proteins
protein_family
SKP1 family
uniprot
proteins
pubmed
10213691
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8202474
uniprot
proteins
sequence_length
112
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15369}.
uniprot
proteins