SENP6
entrez
26054
canonical
uniprot
Q9GZR1
canonical
ensembl
ENSG00000112701
resolver
ensp
ENSP00000321820
resolver
ensp
ENSP00000359027
resolver
ensp
ENSP00000402527
resolver
enst
ENST00000327284
resolver
genesymbol
SENP6
resolver
genesymbol_syn
KIAA0797
resolver
genesymbol_syn
SSP1
resolver
genesymbol_syn
SUSP1
resolver
hgnc
HGNC:20944
resolver
uniprot
A6NNY9
resolver
uniprot
B3KMM0
resolver
uniprot
F8W6D9
resolver
uniprot
O94891
resolver
uniprot
Q5VUL3
resolver
uniprot
Q5VUL4
resolver
uniprot
Q8TBY4
resolver
uniprot
Q9UJV5
resolver
uniprot_entry
B3KMM0_HUMAN
resolver
uniprot_entry
F8W6D9_HUMAN
resolver
uniprot_entry
SENP6_HUMAN
resolver
uniprot_sec
A6NNY9
resolver
uniprot_sec
O94891
resolver
uniprot_sec
Q5VUL3
resolver
uniprot_sec
Q5VUL4
resolver
uniprot_sec
Q8TBY4
resolver
uniprot_sec
Q9UJV5
resolver
amino_acid_sequence
MAAGKSGGSAGEITFLEALARSESKRDGGFKNNWSFDHEEESEGDTDKDGTNLLSVDEDEDSETSKGKKLNRRSEIVANSSGEFILKTYVRRNKSESFKTLKGNPIGLNMLSNNKKLSENTQNTSLCSGTVVHGRRFHHAHAQIPVVKTAAQSSLDRKERKEYPPHVQKVEINPVRLSRLQGVERIMKKTEESESQVEPEIKRKVQQKRHCSTYQPTPPLSPASKKCLTHLEDLQRNCRQAITLNESTGPLLRTSIHQNSGGQKSQNTGLTTKKFYGNNVEKVPIDIIVNCDDSKHTYLQTNGKVILPGAKIPKITNLKERKTSLSDLNDPIILSSDDDDDNDRTNRRESISPQPADSACSSPAPSTGKVEAALNENTCRAERELRSIPEDSELNTVTLPRKARMKDQFGNSIINTPLKRRKVFSQEPPDALALSCQSSFDSVILNCRSIRVGTLFRLLIEPVIFCLDFIKIQLDEPDHDPVEIILNTSDLTKCEWCNVRKLPVVFLQAIPAVYQKLSIQLQMNKEDKVWNDCKGVNKLTNLEEQYIILIFQNGLDPPANMVFESIINEIGIKNNISNFFAKIPFEEANGRLVACTRTYEESIKGSCGQKENKIKTVSFESKIQLRSKQEFQFFDEEEETGENHTIFIGPVEKLIVYPPPPAKGGISVTNEDLHCLNEGEFLNDVIIDFYLKYLVLEKLKKEDADRIHIFSSFFYKRLNQRERRNHETTNLSIQQKRHGRVKTWTRHVDIFEKDFIFVPLNEAAHWFLAVVCFPGLEKPKYEPNPHYHENAVIQKCSTVEDSCISSSASEMESCSQNSSAKPVIKKMLNKKHCIAVIDSNPGQEESDPRYKRNICSVKYSVKKINHTASENEEFNKGESTSQKVADRTKSENGLQNESLSSTHHTDGLSKIRLNYSDESPEAGKMLEDELVDFSEDQDNQDDSSDDGFLADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKILREYLEVEWEVKKGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQEDQSKEKRKHKDTYSTEAPLGEGTEQYVNSISD
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
function
FUNCTION: Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}.
uniprot
proteins
mass_dalton
126146
uniprot
proteins
mutagenesis
MUTAGEN 1030; /note="C->S: Abolishes enzymatic activity."; /evidence="ECO:0000269|PubMed:16912044
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein sumoylation.
uniprot
proteins
protein_family
Peptidase C48 family
uniprot
proteins
pubmed
10799485
uniprot
proteins
pubmed
10806345
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16912044
uniprot
proteins
pubmed
17000875
uniprot
proteins
pubmed
17704809
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18799455
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20212317
uniprot
proteins
pubmed
20705237
uniprot
proteins
pubmed
21148299
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
1112
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875}.
uniprot
proteins