Cadm2
entrez
239857
canonical
uniprot
Q8BLQ9
canonical
ensembl
ENSMUSG00000064115
resolver
ensp
ENSMUSP00000109931
resolver
ensp
ENSMUSP00000113178
resolver
ensp
ENSMUSP00000113500
resolver
ensp
ENSMUSP00000134554
resolver
genesymbol
Cadm2
resolver
genesymbol_syn
Igsf4d
resolver
genesymbol_syn
Necl3
resolver
uniprot
B1B1A5
resolver
uniprot
B1B1A6
resolver
uniprot
B2RTL0
resolver
uniprot
Q8BXJ7
resolver
uniprot
Q8BYP1
resolver
uniprot
Q8BZP4
resolver
uniprot_entry
CADM2_MOUSE
resolver
uniprot_sec
B1B1A5
resolver
uniprot_sec
B1B1A6
resolver
uniprot_sec
B2RTL0
resolver
uniprot_sec
Q8BXJ7
resolver
uniprot_sec
Q8BYP1
resolver
uniprot_sec
Q8BZP4
resolver
amino_acid_sequence
MIWKRSAVLRFYSVCGLLLQGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQALTLTCESKGKPLPEPVLWTKDGAELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDVPNTLLPTTIIPSLTTAPVTTSVTITTSPSTSASSSSRRDPNSLAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQVNAEEKKEYFI
uniprot
proteins
function
FUNCTION: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
47559
uniprot
proteins
post_translational_modification
PTM: Glycosylation at Asn-51 reduces adhesive binding. {ECO:0000269|PubMed:20739279}.
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20739279
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
39327467
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:39327467}; Single-pass type I membrane protein {ECO:0000255}. Synapse {ECO:0000250|UniProtKB:Q8N3J6}. Cell projection, axon {ECO:0000250|UniProtKB:Q8N3J6}. Note=Found in the axoplasm of myelinated axons. {ECO:0000250|UniProtKB:Q8N3J6}.
uniprot
proteins
transmembrane_region
TRANSMEM 368..388; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins