IL3
entrez
3562
canonical
uniprot
P08700
canonical
ensembl
ENSG00000164399
resolver
ensp
ENSP00000296870
resolver
enst
ENST00000296870
resolver
genesymbol
IL3
resolver
hgnc
HGNC:6011
resolver
uniprot
Q6GS87
resolver
uniprot_entry
IL3_HUMAN
resolver
uniprot_sec
Q6GS87
resolver
amino_acid_sequence
MSRLPVLLLLQLLVRPGLQAPMTQTTPLKTSWVNCSNMIDEIITHLKQPPLPLLDFNNLNGEDQDILMENNLRRPNLEAFNRAVKSLQNASAIESILKNLLPCLPLATAAPTRHPIHIKDGDWNEFRRKLTFYLKTLENAQAQQTTLSLAIF
uniprot
proteins
function
FUNCTION: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:2556442). Also stimulates mature basophils, eosinophils, and monocytes to become functionally activated (PubMed:10779277, PubMed:32889153). In addition, plays an important role in neural cell proliferation and survival (PubMed:23226269). Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation (PubMed:12816992). Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (PubMed:29374162). Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (By similarity). Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (PubMed:27862234). {ECO:0000250|UniProtKB:P01586, ECO:0000269|PubMed:10779277, ECO:0000269|PubMed:12816992, ECO:0000269|PubMed:23226269, ECO:0000269|PubMed:2556442, ECO:0000269|PubMed:27862234, ECO:0000269|PubMed:29374162, ECO:0000269|PubMed:32889153}.
uniprot
proteins
mass_dalton
17233
uniprot
proteins
protein_family
IL-3 family
uniprot
proteins
pubmed
10779277
uniprot
proteins
pubmed
12816992
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23226269
uniprot
proteins
pubmed
2544122
uniprot
proteins
pubmed
2556442
uniprot
proteins
pubmed
27862234
uniprot
proteins
pubmed
29374162
uniprot
proteins
pubmed
3127463
uniprot
proteins
pubmed
32889153
uniprot
proteins
pubmed
3489530
uniprot
proteins
pubmed
3497843
uniprot
proteins
pubmed
8676386
uniprot
proteins
sequence_length
152
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins