Npr1
entrez
24603
canonical
uniprot
P18910
canonical
ensembl
ENSRNOG00000014684
resolver
ensembl
ENSRNOG00055022138
resolver
ensembl
ENSRNOG00060032283
resolver
ensembl
ENSRNOG00065026951
resolver
ensp
ENSRNOP00000020307
resolver
ensp
ENSRNOP00055031060
resolver
ensp
ENSRNOP00060046263
resolver
ensp
ENSRNOP00065038139
resolver
enst
ENSRNOT00055038069
resolver
enst
ENSRNOT00060055935
resolver
enst
ENSRNOT00065046512
resolver
genesymbol
Npr1
resolver
uniprot
A1A5N8
resolver
uniprot_entry
ANPRA_RAT
resolver
uniprot_sec
A1A5N8
resolver
amino_acid_sequence
MPGSRRVRPRLRALLLLPPLLLLRGGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYWPLGYPPPDVPKCGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGERGCSTRG
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Plays an essential role in the regulation of endothelial cell senescence and vascular aging. Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis. {ECO:0000250|UniProtKB:P16066}.
uniprot
proteins
mass_dalton
118951
uniprot
proteins
mutagenesis
MUTAGEN 197; /note="E->K: Abolishes hormone binding."; /evidence="ECO:0000269|PubMed:10894551"; MUTAGEN 213; /note="H->D: Abolishes hormone binding."; /evidence="ECO:0000269|PubMed:10894551"; MUTAGEN 338; /note="E->H: Decreased ANP-dependent guanylate cyclase activity; when associated with P-364."; /evidence="ECO:0000269|PubMed:1679239"; MUTAGEN 364; /note="L->P: Decreased ANP-dependent guanylate cyclase activity; when associated with H-338."; /evidence="ECO:0000269|PubMed:1679239"; MUTAGEN 364; /note="Missing: Loss of ANP binding and ANP-dependent guanylate cyclase activities."; /evidence="ECO:0000269|PubMed:1679239"; MUTAGEN 522; /note="S->A: No effect on phosphorylation, 15% loss of ANP-dependent activity."; /evidence="ECO:0000269|PubMed:9528788"; MUTAGEN 525; /note="S->A: Reduced phosphorylation, 80% loss of ANP-dependent activity."; /evidence="ECO:0000269|PubMed:9528788"; MUTAGEN 525; /note="S->E: No effect on ANP-dependent activity."; /evidence="ECO:0000269|PubMed:9528788"; MUTAGEN 528; /note="T->A: Reduced phosphorylation, 50% loss of ANP-dependent activity."; /evidence="ECO:0000269|PubMed:9528788"; MUTAGEN 530; /note="S->A: Reduced phosphorylation, 50% loss of ANP-dependent activity."; /evidence="ECO:0000269|PubMed:9528788"; MUTAGEN 534; /note="S->A: Reduced phosphorylation, 50% loss of ANP-dependent activity."; /evidence="ECO:0000269|PubMed:9528788"; MUTAGEN 538; /note="S->A: Reduced phosphorylation, 60% loss of CNP-dependent activity."; /evidence="ECO:0000269|PubMed:9528788"; MUTAGEN 541; /note="T->A: Markedly reduced phosphorylation, 50% loss of CNP-dependent activity."; /evidence="ECO:0000269|PubMed:9528788"; MUTAGEN 542; /note="T->A: No effect on phosphorylation, 30% loss of ANP-dependent activity."; /evidence="ECO:0000269|PubMed:9528788
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of the protein kinase-like domain is required for full activation by ANP. {ECO:0000269|PubMed:20977274, ECO:0000269|PubMed:9528788}.
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
10894551
uniprot
proteins
pubmed
15117952
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1679239
uniprot
proteins
pubmed
1978722
uniprot
proteins
pubmed
20977274
uniprot
proteins
pubmed
2563900
uniprot
proteins
pubmed
9528788
uniprot
proteins
sequence_length
1057
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:2563900}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins