G2E3
entrez
55632
canonical
uniprot
Q7L622
canonical
ensembl
ENSG00000092140
resolver
ensp
ENSP00000206595
resolver
ensp
ENSP00000391068
resolver
ensp
ENSP00000451653
resolver
ensp
ENSP00000548939
resolver
ensp
ENSP00000600434
resolver
ensp
ENSP00000677647
resolver
enst
ENST00000206595
resolver
enst
ENST00000438909
resolver
enst
ENST00000930375
resolver
genesymbol
G2E3
resolver
genesymbol_syn
KIAA1333
resolver
hgnc
HGNC:20338
resolver
uniprot
B4DIF9
resolver
uniprot
B4DL73
resolver
uniprot
F5GX24
resolver
uniprot
Q49AD9
resolver
uniprot
Q9BVR2
resolver
uniprot
Q9H9E9
resolver
uniprot
Q9NXC0
resolver
uniprot
Q9P2L3
resolver
uniprot_entry
B4DIF9_HUMAN
resolver
uniprot_entry
B4DL73_HUMAN
resolver
uniprot_entry
F5GX24_HUMAN
resolver
uniprot_entry
G2E3_HUMAN
resolver
uniprot_entry
Q49AD9_HUMAN
resolver
uniprot_sec
Q9BVR2
resolver
uniprot_sec
Q9H9E9
resolver
uniprot_sec
Q9NXC0
resolver
uniprot_sec
Q9P2L3
resolver
amino_acid_sequence
MNESKPGDSQNLACVFCRKHDDCPNKYGEKKTKEKWNLTVHYYCLLMSSGIWQRGKEEEGVYGFLIEDIRKEVNRASKLKCCVCKKNGASIGCVAPRCKRSYHFPCGLQRECIFQFTGNFASFCWDHRPVQIITSNNYRESLPCTICLEFIEPIPSYNILRSPCCKNAWFHRDCLQVQAINAGVFFFRCTICNNSDIFQKEMLRMGIHIPEKDASWELEENAYQELLQHYERCDVRRCRCKEGRDYNAPDSKWEIKRCQCCGSSGTHLACSSLRSWEQNWECLECRGIIYNSGEFQKAKKHVLPNSNNVGITDCLLEESSPKLPRQSPGSQSKDLLRQGSKFRRNVSTLLIELGFQIKKKTKRLYINKANIWNSALDAFRNRNFNPSYAIEVAYVIENDNFGSEHPGSKQEFLSLLMQHLENSSLFEGSLSKNLSLNSQALKENLYYEAGKMLAISLVHGGPSPGFFSKTLFNCLVYGPENTQPILDDVSDFDVAQIIIRINTATTVADLKSIINECYNYLELIGCLRLITTLSDKYMLVKDILGYHVIQRVHTPFESFKQGLKTLGVLEKIQAYPEAFCSILCHKPESLSAKILSELFTVHTLPDVKALGFWNSYLQAVEDGKSTTTMEDILIFATGCSSIPPAGFKPTPSIECLHVDFPVGNKCNNCLAIPITNTYKEFQENMDFTIRNTLRLEKEESSHYIGH
uniprot
proteins
ec_number
2.3.2.26
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase involved in the establishment of constitutive heterochromatin at pericentric regions by catalyzing histone H3 'Lys-14' monoubiquitination (H3K14ub) (PubMed:41094145). H3K14ub represents a specific tag for heterochromatin formation by facilitating the deposition of histone H3 trimethylated at 'Lys-9' (H3K9me3) (PubMed:41094145). Highly expressed in G2/M phase and associates with mitotic chromosomes in an RNA-dependent manner to catalyze H3K14ub, thereby promoting recruitment of SUV39H (SUV39H1 and/or SUV39H2) and subsequent recruitment of HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones (PubMed:41094145). {ECO:0000269|PubMed:41094145}.
uniprot
proteins
mass_dalton
80504
uniprot
proteins
mutagenesis
MUTAGEN 30..31; /note="KK->AA: Loss of nucleolar localization. No effect on nuclear localization."; /evidence="ECO:0000269|PubMed:17239372"; MUTAGEN 84; /note="C->A: In G2E3mut1; abolished ability to mediate monoubiquitination of histone H3 at K-15 (H3K14ub). No E3 ubiquitin-protein ligase activity; when associated with A-147, A-258 and A-261."; /evidence="ECO:0000269|PubMed:18511420, ECO:0000269|PubMed:41094145"; MUTAGEN 147; /note="C->A: In G2E3mut2; abolished ability to mediate monoubiquitination of histone H3 at K-15 (H3K14ub). No E3 ubiquitin-protein ligase activity; when associated with A-84, A-258 and A-261."; /evidence="ECO:0000269|PubMed:18511420, ECO:0000269|PubMed:41094145"; MUTAGEN 258..261; /note="CQCC->AQCA: In G2E3mut3; abolished ability to mediate monoubiquitination of histone H3 at K-15 (H3K14ub)."; /evidence="ECO:0000269|PubMed:41094145"; MUTAGEN 258; /note="C->A: No E3 ubiquitin-protein ligase activity; when associated with A-84, A-147 and A-261. No E3 ubiquitin-protein ligase activity; when associated with A-147, A-261 and A-666."; /evidence="ECO:0000269|PubMed:18511420"; MUTAGEN 261; /note="C->A: No E3 ubiquitin-protein ligase activity; when associated with A-84, A-147 and A-258. No E3 ubiquitin-protein ligase activity; when associated with A-147, A-258 and A-666."; /evidence="ECO:0000269|PubMed:18511420"; MUTAGEN 666; /note="C->A: In G2E3mut4; abolished ability to mediate monoubiquitination of histone H3 at K-15 (H3K14ub). No effect on subcellular location. No E3 ubiquitin-protein ligase activity; when associated with A-147, A-258 and A-261."; /evidence="ECO:0000269|PubMed:17239372, ECO:0000269|PubMed:18511420, ECO:0000269|PubMed:41094145
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:18511420, ECO:0000269|PubMed:41094145}.
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
11483598
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17239372
uniprot
proteins
pubmed
18511420
uniprot
proteins
pubmed
41094145
uniprot
proteins
sequence_length
706
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17239372, ECO:0000269|PubMed:41094145}. Chromosome {ECO:0000269|PubMed:41094145}. Nucleus, nucleolus {ECO:0000269|PubMed:17239372}. Cytoplasm {ECO:0000269|PubMed:17239372}. Note=Shuttles between the nucleus and the cytoplasm (PubMed:17239372). In the nucleus, delocalizes from the nucleolus to the nucleoplasm in response to DNA damage (PubMed:17239372). Associates with mitotic chromosomes; enriched at pericentromeric heterochromatin (PubMed:41094145). {ECO:0000269|PubMed:17239372, ECO:0000269|PubMed:41094145}.
uniprot
proteins