CDH5
entrez
1003
canonical
uniprot
P33151
canonical
ensembl
ENSG00000179776
resolver
ensp
ENSP00000344115
resolver
ensp
ENSP00000564922
resolver
ensp
ENSP00000662629
resolver
genesymbol
CDH5
resolver
hgnc
HGNC:1764
resolver
uniprot
Q4VAI5
resolver
uniprot
Q4VAI6
resolver
uniprot
Q59EA3
resolver
uniprot_entry
CADH5_HUMAN
resolver
uniprot_entry
Q59EA3_HUMAN
resolver
uniprot_sec
Q4VAI5
resolver
uniprot_sec
Q4VAI6
resolver
amino_acid_sequence
MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGSDPREELLY
uniprot
proteins
function
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (PubMed:10861224). Plays a role in coupling actin fibers to cell junctions in endothelial cells, via acting as a cell junctional complex anchor for AMOTL2 and MAGI1 (By similarity). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (PubMed:20332120). Positively regulates reorientation of actin stress fibers and endothelial cell reorientation in response to cellular mechantransduction (PubMed:25795300). Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (PubMed:20332120). Associates with CTNND1/p120-catenin to control CADH5 endocytosis (By similarity). {ECO:0000250|UniProtKB:P55284, ECO:0000250|UniProtKB:Q8AYD0, ECO:0000269|PubMed:10861224, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21269602, ECO:0000269|PubMed:25795300}.
uniprot
proteins
mass_dalton
87528
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB (By similarity). {ECO:0000250}.; PTM: O-glycosylated. {ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:21269602}.
uniprot
proteins
pubmed
10861224
uniprot
proteins
pubmed
1522121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15980433
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
19996314
uniprot
proteins
pubmed
20332120
uniprot
proteins
pubmed
2059658
uniprot
proteins
pubmed
21183689
uniprot
proteins
pubmed
21269602
uniprot
proteins
pubmed
25795300
uniprot
proteins
pubmed
27338829
uniprot
proteins
pubmed
27466317
uniprot
proteins
pubmed
7627717
uniprot
proteins
pubmed
9219219
uniprot
proteins
sequence_length
784
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21183689, ECO:0000269|PubMed:25795300, ECO:0000269|PubMed:27338829}. Cell membrane {ECO:0000269|PubMed:15980433, ECO:0000305|PubMed:20332120}; Single-pass type I membrane protein {ECO:0000305|PubMed:20332120}. Cytoplasm {ECO:0000250|UniProtKB:P55284}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. {ECO:0000269|PubMed:20332120}.
uniprot
proteins
transmembrane_region
TRANSMEM 600..620; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins