CYP2J2
entrez
1573
canonical
uniprot
P51589
canonical
ensembl
ENSG00000134716
resolver
ensp
ENSP00000360247
resolver
enst
ENST00000371204
resolver
genesymbol
CYP2J2
resolver
hgnc
HGNC:2634
resolver
uniprot
B2RD33
resolver
uniprot
Q8TF13
resolver
uniprot_entry
CP2J2_HUMAN
resolver
uniprot_sec
B2RD33
resolver
uniprot_sec
Q8TF13
resolver
amino_acid_sequence
MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAVPQV
uniprot
proteins
ec_number
1.14.14.-
uniprot
proteins
ec_number
1.14.14.73
uniprot
proteins
ec_number
1.14.14.74
uniprot
proteins
ec_number
5.4.4.7
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:19965576, PubMed:8631948). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:19965576, PubMed:8631948). Catalyzes the epoxidation of double bonds of PUFA (PubMed:19965576, PubMed:8631948). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256). {ECO:0000269|PubMed:19737933, ECO:0000269|PubMed:19923256, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:23959307, ECO:0000269|PubMed:8631948}.
uniprot
proteins
mass_dalton
57611
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; arachidonate metabolism. {ECO:0000269|PubMed:19737933, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:8631948}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
11901223
uniprot
proteins
pubmed
12386130
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19737933
uniprot
proteins
pubmed
19923256
uniprot
proteins
pubmed
19965576
uniprot
proteins
pubmed
23959307
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8631948
uniprot
proteins
sequence_length
502
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:8631948}; Peripheral membrane protein.
uniprot
proteins