Q922B6
uniprot
Q922B6
canonical
amino_acid_sequence
MPPINTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLVFAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNAKLTVVVNNIAVAEQIGELFIHCRHGCHAAGTGKPGVFEVDPRGCPFTIKLSARKDHESSCDYRPVRCPNNPSCPPLLKMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNMLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVWTC
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis (PubMed:16162816, PubMed:34953447). Potentiates MAP3K3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators (By similarity). Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation (PubMed:16162816). Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Negatively regulates RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1 through its RING domain to inhibit the cellular antiviral response (By similarity). Promotes 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA leading to targeting these two proteins to lysosomal degradative pathways, reducing the transcriptional activity of NF-kappa-B (By similarity). {ECO:0000250|UniProtKB:Q6Q0C0, ECO:0000269|PubMed:16162816, ECO:0000269|PubMed:34953447}.
uniprot
proteins
mass_dalton
66487
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAP3K3. {ECO:0000250|UniProtKB:Q6Q0C0}.; PTM: Ubiquitinates itself upon phosphorylation. {ECO:0000250|UniProtKB:Q6Q0C0}.
uniprot
proteins
protein_family
WD repeat TRAF7 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16162816
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34953447
uniprot
proteins
sequence_length
594
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q6Q0C0}. Cytoplasm {ECO:0000269|PubMed:16162816}. Nucleus {ECO:0000269|PubMed:16162816}. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm. {ECO:0000250|UniProtKB:Q6Q0C0}.
uniprot
proteins