Epha7
entrez
13841
canonical
uniprot
Q61772
canonical
ensembl
ENSMUSG00000028289
resolver
ensp
ENSMUSP00000029964
resolver
ensp
ENSMUSP00000079735
resolver
ensp
ENSMUSP00000103826
resolver
ensp
ENSMUSP00000103829
resolver
ensp
ENSMUSP00000221093
resolver
ensp
ENSMUSP00000221096
resolver
ensp
ENSMUSP00000221124
resolver
enst
ENSMUST00000108191
resolver
genesymbol
Epha7
resolver
genesymbol_syn
Ebk
resolver
genesymbol_syn
Ehk3
resolver
genesymbol_syn
Mdk1
resolver
uniprot
A2BDQ4
resolver
uniprot
Q61505
resolver
uniprot
Q61773
resolver
uniprot
Q61774
resolver
uniprot
Q8BSU8
resolver
uniprot
Q8CC52
resolver
uniprot_entry
A2BDQ4_MOUSE
resolver
uniprot_entry
EPHA7_MOUSE
resolver
uniprot_entry
Q8CC52_MOUSE
resolver
uniprot_sec
Q61505
resolver
uniprot_sec
Q61773
resolver
uniprot_sec
Q61774
resolver
uniprot_sec
Q8BSU8
resolver
amino_acid_sequence
MVVQTRFPSWIILCYIWLLGFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPSGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRTNWISKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKKGFYLAFQDVGACIALVSVKVYYKKCWSIVENLAVFPDTVTGSEFSSLVEVRGTCVSSAEEEAENSPRMHCSAEGEWLVPIGKCICKAGYQQKGDTCEPCGRRFYKSSSQDLQCSRCPTHSFSDREGSSRCECEDGYYRAPSDPPYVACTRPPSAPQNLIFNINQTTVSLEWSPPADNGGRNDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAAPSQVSGVMKERVLQRSVQLSWQEPEHPNGVITEYEIKYYEKDQRERTYSTLKTKSTSASINNLKPGTVYVFQIRAVTAAGYGNYSPRLDVATLEEASGKMFEATAVSSEQNPVIIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDEELYFHFKFPGTKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKDRAERPKFEQIVGILDKMIRNPSSLKTPLGTCSRPLSPLLDQSTPDFTAFCSVGEWLQAIKMERYKDNFTAAGYNSLESVARMTIDDVMSLGITLVGHQKKIMSSIQTMRAQMLHLHGTGIQV
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7. Isoform 4 which lacks the kinase domain may regulate isoform 1 adhesive properties. {ECO:0000269|PubMed:15902206, ECO:0000269|PubMed:15996548, ECO:0000269|PubMed:16301174}.
uniprot
proteins
mass_dalton
111860
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Isoform 4 inhibits isoform 1 phosphorylation and may regulate its function in adhesion. {ECO:0000269|PubMed:11089974}.
uniprot
proteins
protein_family
Ephrin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
11089974
uniprot
proteins
pubmed
15902206
uniprot
proteins
pubmed
15996548
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16301174
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27446912
uniprot
proteins
pubmed
7824284
uniprot
proteins
pubmed
8541219
uniprot
proteins
pubmed
9368721
uniprot
proteins
pubmed
9883737
uniprot
proteins
sequence_length
998
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:11089974}; Single-pass type I membrane protein {ECO:0000305|PubMed:11089974}.
uniprot
proteins
transmembrane_region
TRANSMEM 556..576; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins