SMYD4
entrez
114826
canonical
uniprot
Q8IYR2
canonical
ensembl
ENSG00000186532
resolver
ensp
ENSP00000304360
resolver
ensp
ENSP00000624831
resolver
ensp
ENSP00000624833
resolver
ensp
ENSP00000715404
resolver
ensp
ENSP00000715406
resolver
enst
ENST00000305513
resolver
enst
ENST00000954772
resolver
enst
ENST00000954774
resolver
genesymbol
SMYD4
resolver
genesymbol_syn
KIAA1936
resolver
hgnc
HGNC:21067
resolver
uniprot
Q8N1P2
resolver
uniprot
Q8NAT0
resolver
uniprot
Q96LV4
resolver
uniprot
Q96PV2
resolver
uniprot_entry
SMYD4_HUMAN
resolver
uniprot_sec
Q8N1P2
resolver
uniprot_sec
Q8NAT0
resolver
uniprot_sec
Q96LV4
resolver
uniprot_sec
Q96PV2
resolver
amino_acid_sequence
MDLPVDEWKSYLLQKWASLPTSVQVTISTAETLRDIFLHSSSLLQPEDELFLKRLSKGYLVGKDSDAPLFYREEGNKKFQEKDYTGAAVLYSKGVSHSRPNTEDMSLCHANRSAALFHLGQYETCLKDINRAQTHGYPERLQPKIMLRKAECLVALGRLQEASQTISDLERNFTATPALADVLPQTLQRNLHRLKMKMQEKDSLTESFPAALAKTLEDAALREENEQLSNASSSIGLCVDPLKGRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLKHTLATVPCDGCSYAKYCSQECLQQAWELYHRTECPLGGLLLTLGVFCHIALRLTLLVGFEDVRKIITKLCDKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAVFNLLPHTENHSPEHKFLCALCVSALCRQLEAASLQAIPTERIVNSSQLKAAVTPELCPDVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATIRASQRIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPACQTEAHRMAAGPRWEAFCCNSCGAPMQGDDVLRCGSRSCAESAVSRDHLVSRLQDLQQQVRVAQKLLRDGELERAVQRLSGCQRDAESFLWAEHAVVGEIADGLARACAALGDWQKSATHLQRSLYVVEVRHGPSSVEMGHELFKLAQIFFNGFAVPEALSTIQKAEEVLSLHCGPWDDEIQELQKMKSCLLDLPPTPVGPAL
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity (PubMed:38438251). May also act as a histone methyltransferase (By similarity). Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1 (By similarity). {ECO:0000250|UniProtKB:Q08C84, ECO:0000269|PubMed:38438251}.
uniprot
proteins
mass_dalton
89225
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
11572484
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
30110327
uniprot
proteins
pubmed
38438251
uniprot
proteins
sequence_length
804
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:38438251}. Cytoplasm {ECO:0000269|PubMed:38438251}.
uniprot
proteins