Npc1l1
entrez
432367
canonical
uniprot
Q6T3U3
canonical
ensembl
ENSRNOG00000049955
resolver
ensp
ENSRNOP00000065524
resolver
enst
ENSRNOT00000075827
resolver
genesymbol
Npc1l1
resolver
uniprot_entry
NPCL1_RAT
resolver
amino_acid_sequence
MAAAWLGWLLWALLLSAAQGELYTPKHEAGVCTFYEECGKNPELSGGLTSLSNVSCLSNTPARHVTGEHLALLQRICPRLYNGPNTTFACCSTKQLLSLESSMSITKALLTRCPACSDNFVSLHCHNTCSPDQSLFINVTRVVERGAGEPPAVVAYEAFYQRSFAEKAYESCSQVRIPAAASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALPDGIQPLNGKIAPCNESQGDDSAVCSCQDCAASCPVIPPPEALRPSFYMGRMPGWLALIIIFTAVFVLLSAVLVRLRVVSNRNKNKAEGPQEAPKLPHKHKLSPHTILGRFFQNWGTRVASWPLTVLALSFIVVIALAAGLTFIELTTDPVELWSAPKSQARKEKSFHDEHFGPFFRTNQIFVTARNRSSYKYDSLLLGSKNFSGILSLDFLLELLELQERLRHLQVWSPEAERNISLQDICYAPLNPYNTSLSDCCVNSLLQYFQNNRTLLMLTANQTLNGQTSLVDWKDHFLYCANAPLTFKDGTSLALSCMADYGAPVFPFLAVGGYQGTDYSEAEALIITFSLNNYPADDPRMAQAKLWEEAFLKEMESFQRNTSDKFQVAFSAERSLEDEINRTTIQDLPVFAVSYIIVFLYISLALGSYSRCSRVAVESKATLGLGGVIVVLGAVLAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPGEQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAIILDFLLQMTAFVALLSLDSKRQEASRPDVLCCFSTRKLPPPKEKEGLLLRFFRKIYAPFLLHRFIRPVVMLLFLTLFGANLYLMCNINVGLDQELALPKDSYLIDYFLFLNRYLEVGPPVYFVTTSGFNFSSEAGMNATCSSAGCKSFSLTQKIQYASEFPDQSYVAIAASSWVDDFIDWLTPSSSCCRLYIRGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRPTAEQFHKYLPWFLNDPPNIRCPKGGLAAYRTSVNLSSDGQVIASQFMAYHKPLRNSQDFTEALRASRLLAANITADLRKVPGTDPNFEVFPYTISNVFYQQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDMCSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLERAKDATVFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLPVVLSYLGPDVNQALVQEEKLASEAAVAPEPSCPQYPSPADADANVNYGFAPELAHGANAARSSLPKSDQKF
uniprot
proteins
function
FUNCTION: Plays a major role in cholesterol homeostasis (PubMed:17135346). Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed:17135346). Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol (PubMed:17135346). Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia (PubMed:15928087). May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation (By similarity). May be involved in caveolin trafficking from the plasma membrane (By similarity). Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation (By similarity). {ECO:0000250|UniProtKB:Q6T3U4, ECO:0000250|UniProtKB:Q9UHC9, ECO:0000269|PubMed:15928087, ECO:0000269|PubMed:17135346}.
uniprot
proteins
mass_dalton
146415
uniprot
proteins
post_translational_modification
PTM: Highly glycosylated.
uniprot
proteins
protein_family
Patched family
uniprot
proteins
pubmed
14976318
uniprot
proteins
pubmed
15777641
uniprot
proteins
pubmed
15928087
uniprot
proteins
pubmed
17135346
uniprot
proteins
pubmed
29880681
uniprot
proteins
sequence_length
1331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:17135346}; Multi-pass membrane protein. Cell membrane {ECO:0000269|PubMed:29880681}; Multi-pass membrane protein. Note=Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein. {ECO:0000269|PubMed:14976318}.
uniprot
proteins
transmembrane_region
TRANSMEM 283..303; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 353..373; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 633..653; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 666..686; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 697..717; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 743..763; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 777..797; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 847..867; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 1114..1134; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 1143..1163; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 1166..1186; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 1207..1227; /note="Helical; Name=12"; /evidence="ECO:0000255"; TRANSMEM 1243..1263; /note="Helical; Name=13"; /evidence="ECO:0000255
uniprot
proteins