Drc2
entrez
362994
canonical
uniprot
Q5XIJ8
canonical
ensembl
ENSRNOG00000058916
resolver
ensp
ENSRNOP00000071850
resolver
ensp
ENSRNOP00000108892
resolver
enst
ENSRNOT00000137510
resolver
genesymbol
Drc2
resolver
genesymbol_syn
Ccdc65
resolver
uniprot
A0ABK0LS14
resolver
uniprot_entry
A0ABK0LS14_RAT
resolver
uniprot_entry
DRC2_RAT
resolver
amino_acid_sequence
MPKKGKKPKLPLTDEEQLILFQQKLLADEEAAKKKERLLTQFLKDKLAKEEHNSSLNLNKINTQWRTVLREVKTRELHKDIEILSQIFERVVDCKDSVIKSLARDLTEAEEQYAHALRGHLHNVDQLLTLQRRRLSLLEENYNMELEVLTKEFETERKAILDHHDKEIHYLHDVFMAMEQNYVDSEYESKLEFQSMWDDLKNKNLEEKHFLRLQLENVVEDLWRRFQDALKNYTDATEDRKIAFETLKVKDEKSSKEIEVQMKKIQRLQEAISALKGKIVAHSREGEWQNQCIRNDKELVHVQLRKLKIQRTQARTESQENLVKLTLESNATLKALKKVVEKGEKILKLAEICRKFETEEEKVLPFYSSALTPEEQEEVEIQSQEEITEDLAKIMMDYLGMENFWKRYNKVKLEVLSLQHRRLQLLDISSKLREMLKQYLDGISVSDEVLSRLNPLFIVNHKSNLPQLPPSAAQPGGDRGPGGDRRLTYNVIEAAHIASHIL
uniprot
proteins
function
FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. {ECO:0000250|UniProtKB:A8JB22, ECO:0000250|UniProtKB:Q8IXS2}.
uniprot
proteins
mass_dalton
59004
uniprot
proteins
protein_family
DRC2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
502
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000250|UniProtKB:A8JB22}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:A8JB22}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8JB22}.
uniprot
proteins