DGKK
entrez
139189
canonical
uniprot
Q5KSL6
canonical
ensembl
ENSG00000274588
resolver
ensp
ENSP00000477515
resolver
enst
ENST00000611977
resolver
genesymbol
DGKK
resolver
hgnc
HGNC:32395
resolver
uniprot
B2RP91
resolver
uniprot_entry
DGKK_HUMAN
resolver
uniprot_sec
B2RP91
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited in response to H(2)O(2). {ECO:0000269|PubMed:16210324}.
uniprot
proteins
amino_acid_sequence
MDRGAAAAQGTAPPQDGEQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPEPCPELAPGPCPEATSESATELYTEPTPEPATEPASEPAPEPATEPAPEPATEPAPEPAPEPATESAPEPTPEPALESVPEPAPELTPEVAPELAPEPTPEPVTELAPEFCPEAAPEFRPSPAPCLLQCPVDTRERGLKTSPSPSPSPSPRTPMSWSRIKKILKEGPMLKNCNSFKRWKLRYFLVQGQKLYFAHHPAFAHFETIDLSQATVAESSCRNLCHSFCVITPQRKITLAAPNRKDMEEWINIIKTIQQGEIYKIPAAENNPFLVGMHCWYSSYSHRTQHCNVCRESIPALSRDAIICEVCKVKSHRLCALRASKDCKWNTLSITDDLLLPADEVNMPHQWVEGNMPVSSQCAVCHESCGSYQRLQDFRCLWCNSTVHDDCRRRFSKECCFRSHRSSVIPPTALSDPKGDGQLVVSSDFWNLDWSSACSCPLLIFINSKSGDHQGIVFLRKFKQYLNPSQVFDLLKGGPEAGLSMFKNFARFRILVCGGDGSVSWVLSLIDAFGLHEKCQLAVIPLGTGNDLARVLGWGAFWNKSKSPLDILNRVEQASVRILDRWSVMIRETPRQTPLLKGQVEMDVPRFEAAAIQHLESAATELNKILKAKYPTEMIIATRFLCSAVEDFVVDIVKAWGQIKQNNTAIVSVILKSDLMYDRLSVLIDVLAEEAAATSAEKSATEYADSSKADRKPFIPQIDHIAKCKLELATKAQSLQKSLKLIIFQVEQALDEESRQTISVKNFSSTFFLEDDPEDINQTSPRRRSRRGTLSSISSLKSEDLDNLNLDHLHFTPESIRFKEKCVMNNYFGIGLDAKISLDFNTRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSYRKLEERVHLECDGETISLPNLQGIVVLNITSYAGGINFWGSNTATTEYEAPAIDDGKLEVVAIFGSVQMAMSRIINLHHHRIAQCHEVMITIDGEEGIPVQVDGEAWIQRPGLIKIRYKNAAQMLTRDRDFENSMKMWEYKHTEIQAAPQPQLDFQDSQESLSDEEYAQMQHLARLAENLISKLNDLSKIHQHVSVLMGSVNASANILNDIFYGQDSGNEMGAASCIPIETLSRNDAVDVTFSLKGLYDDTTAFLDEKLLRSAEDETALQSALDAMNKEFKKLSEIDWMNPIFVPEEKSSDTDSRSLRLKIKFPKLGKKKVEEERKPKSGQSVQSFIGNLWHRRHREDEAEGDDPLTPSRSQL
uniprot
proteins
ec_number
2.7.1.107
uniprot
proteins
function
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:16210324, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). {ECO:0000269|PubMed:16210324, ECO:0000269|PubMed:23949095, ECO:0000305}.
uniprot
proteins
mass_dalton
141829
uniprot
proteins
mutagenesis
MUTAGEN 78; /note="Y->F: Induces a strong reduction in phosphorylation but is still sensitive to H(2)O(2)."; /evidence="ECO:0000269|PubMed:16210324"; MUTAGEN 1075; /note="Y->F: Does not affect phosphorylation."; /evidence="ECO:0000269|PubMed:16210324
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000305|PubMed:16210324}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Tyr-78 by some member of the SRC family in response to H(2)O(2). {ECO:0000269|PubMed:16210324}.
uniprot
proteins
protein_family
Eukaryotic diacylglycerol kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16210324
uniprot
proteins
pubmed
23949095
uniprot
proteins
sequence_length
1271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16210324}; Peripheral membrane protein {ECO:0000269|PubMed:16210324}.
uniprot
proteins