Polr3f
entrez
70408
canonical
uniprot
Q921X6
canonical
ensembl
ENSMUSG00000027427
resolver
ensp
ENSMUSP00000028914
resolver
enst
ENSMUST00000028914
resolver
genesymbol
Polr3f
resolver
uniprot
Q544K6
resolver
uniprot
Q8C108
resolver
uniprot_entry
Q8C108_MOUSE
resolver
uniprot_entry
RPC6_MOUSE
resolver
uniprot_sec
Q544K6
resolver
amino_acid_sequence
MAEVKVKVQPPDADPVEIENRIIELCHQFPHGITDQVIQNEMPHIEAQQRAVAINRLLSMGQLDLLRSNTGLLYRIKDSQNAGKMKGSDNQEKLVYQIIEDAGNKGIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVKSVAASKKKVYMLYNLQPDRSVTGGAWYSDQDFESEFVEVLNQQCFKFLQSKAETARESKQNPVIQRNSSFASSHEVWKYICELGISKVELSMEDIETILNTLIYDGKVEMTIIAAKEGTVGSVDGHMKLYRAVNPILPPTGVVRAPCGLCPVFEDCHEGGEISPSNCIYMTEWLEF
uniprot
proteins
function
FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer that coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, including varicella zoster virus. Acts as a nuclear and cytosolic DNA sensor detecting AT-rich DNA, involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA) (By similarity). {ECO:0000250|UniProtKB:Q9H1D9}.
uniprot
proteins
mass_dalton
35652
uniprot
proteins
protein_family
Eukaryotic RPC34/RPC39 RNA polymerase subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H1D9}.
uniprot
proteins