Bhlhe22
entrez
59058
canonical
uniprot
Q8C6A8
canonical
ensembl
ENSMUSG00000025128
resolver
ensp
ENSMUSP00000026120
resolver
enst
ENSMUST00000026120
resolver
genesymbol
Bhlhe22
resolver
genesymbol_syn
Bhlhb5
resolver
uniprot
A0A0R4J056
resolver
uniprot
Q9JL05
resolver
uniprot_entry
A0A0R4J056_MOUSE
resolver
uniprot_entry
BHE22_MOUSE
resolver
uniprot_sec
Q9JL05
resolver
amino_acid_sequence
MERGLHLGAAAASEDDLFLHKSLGTSAAKRLEAAFRSTPPGMDLSLAPPTRERPASSSSPLGCFEPADPEGAGLRLPPPGGGGGASGGGGGVSVPGLLVGSAGVGGEPSLSSLPAGAALCLKYGESAGRGSVAESSGGEQSPDDDSDGLCELVLRAGGPDPRASPRAGGGSAKVAEGCSNAHLHGGSGLPPGGPTSGGGSGGGGGGSSKKSKEQKALRLNINARERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRRLVAYLNQGQAISAASLPSSAAAAAAAAALHPALGAYEQAAGYPFSAGLPPAASCPEKCALFNSVSSSLCKQCTEKP
uniprot
proteins
function
FUNCTION: Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal cord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (PubMed:22284184). {ECO:0000250, ECO:0000269|PubMed:17092954, ECO:0000269|PubMed:18957218, ECO:0000269|PubMed:20346763, ECO:0000269|PubMed:22284184}.
uniprot
proteins
mass_dalton
35217
uniprot
proteins
pubmed
12213201
uniprot
proteins
pubmed
14643684
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17092954
uniprot
proteins
pubmed
18957218
uniprot
proteins
pubmed
20346763
uniprot
proteins
pubmed
22284184
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins