Cacna2d4
entrez
319734
canonical
uniprot
Q5RJF7
canonical
ensembl
ENSMUSG00000041460
resolver
ensp
ENSMUSP00000044660
resolver
ensp
ENSMUSP00000140197
resolver
ensp
ENSMUSP00000158949
resolver
ensp
ENSMUSP00000200408
resolver
enst
ENSMUST00000037434
resolver
genesymbol
Cacna2d4
resolver
uniprot
F8VPL1
resolver
uniprot_entry
CA2D4_MOUSE
resolver
uniprot_entry
F8VPL1_MOUSE
resolver
amino_acid_sequence
MARCPMLSSSHNQDHSGRWTAVWTSLWKTPIILWLLLSDTSLPTVRGQTTVPLETVKLWADTFGRNLYNTVTRYSGSLLLQKKYKDAEPSLKIKEVDGLELVKKFSEDMETMLRRKVEAVESLVEAAEEADLNHEFNASLVFNYYNSVLINEKDDKGNYVELGAEFLLESDAHFSNLRVNVSMSSVQLPTNVYNKDPDILNGVYMSEALNPVFVENFQRDPTLTWQYFGSSTGFFRIYPGIKWMPDENGVIAFDCRNRGWYIQAATSPKDIVILVDISGSMKGLRMAIAKHTITTILDTLGENDFVNIIAYNDYVHYIEPCFKGILVQADRDNREHFKQLVDELMVKGVGVVSQALIEAFEILKQFQESKQGSLCNQAIMLITDGAVEDYEPVFETYNWPDRKVRVFTYLIGREVTFADRMKWIACNNKGYYTQISTLADAQESVMEYLHVLSRPMVINHDHDIIWTEAYMDSRLFTSEAQSLMLLTTVAMPVFSKKNETRSHGILLGVVGSDVTLRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKKLRPKPNYNSVDLSEVEWEDQAEILRTAMINGETGSHSMDVKVPLDKGKRVLFLTNDYFFTDISDTPFSLGVVLTRGHGEYILLGNTSVEEGLHDLLHPDLTLASDWIYCITDIDPDHRKLSQLEAVVRFLTGVDPDLECDEELVREVLFDAVVTAPMEAYWTALALNISEESEPGVDVAFLGTRAGLLRRSLFVGSEKVSDRKFLTPEDEASIFTMDHFPLWYRQASEQPPGSFVFNLRWAEGPDSPGKPVAVRASTAVTVTVDGKTAIAAAVGIQMQADYLQRQFWAAMQQCNAVEGPCLKSCEDTDLDCFVIDNNGFVLISERPQEMGRLLGEADGALMKQLLSMGVFSRVTMYDYQAMCKPPDHHHSAAESLFSPLSAFLMVARWLLHECLLFLLEWSAWGSWQDKGSEAKSVFHHSHKHKKQDLLHPCDTEYPVFVHQTAIQEANGIIECGGCQKTFVMQQIPRSNLLLLVTDRTCDCSAHSPILQEATEVKYNASVKCDRMRSQKPRRRPGSCHAFHPEENAQDCGGASDTLPSSPLLLLSLGAWLLPPQLLW
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Cacna2d4 are a cause of cone-rod dysfunction. Mice display affected retinal ribbon-type synapses. The retinopathy is accompanied by a substantial loss in the activities of the second-order neurons. Rod photoreceptor responses are maintained with reduced amplitude, whereas cone activities are absent. {ECO:0000269|PubMed:16877424}.
uniprot
proteins
function
FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. {ECO:0000250}.
uniprot
proteins
mass_dalton
125991
uniprot
proteins
post_translational_modification
PTM: May be proteolytically processed into subunits alpha-2-4 and delta-4 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Calcium channel subunit alpha-2/delta family
uniprot
proteins
pubmed
15536090
uniprot
proteins
pubmed
16877424
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
1116
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 1095..1115; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins