CDC16
entrez
8881
canonical
uniprot
Q13042
canonical
ensembl
ENSG00000130177
resolver
ensp
ENSP00000252457
resolver
ensp
ENSP00000252458
resolver
ensp
ENSP00000348554
resolver
ensp
ENSP00000353549
resolver
ensp
ENSP00000364457
resolver
ensp
ENSP00000486027
resolver
ensp
ENSP00000497168
resolver
ensp
ENSP00000559333
resolver
ensp
ENSP00000670952
resolver
ensp
ENSP00000670955
resolver
ensp
ENSP00000670956
resolver
ensp
ENSP00000735377
resolver
ensp
ENSP00000791360
resolver
ensp
ENSP00000791361
resolver
enst
ENST00000650489
resolver
genesymbol
CDC16
resolver
genesymbol_syn
ANAPC6
resolver
hgnc
HGNC:1720
resolver
uniprot
A0A3B3ISD2
resolver
uniprot
A2A365
resolver
uniprot
B2RCW0
resolver
uniprot
Q5T8C8
resolver
uniprot
Q7Z651
resolver
uniprot
Q96AE6
resolver
uniprot
Q9Y564
resolver
uniprot_entry
A0A3B3ISD2_HUMAN
resolver
uniprot_entry
B2RCW0_HUMAN
resolver
uniprot_entry
CDC16_HUMAN
resolver
uniprot_sec
A2A365
resolver
uniprot_sec
Q5T8C8
resolver
uniprot_sec
Q7Z651
resolver
uniprot_sec
Q96AE6
resolver
uniprot_sec
Q9Y564
resolver
amino_acid_sequence
MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSDWEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKDKLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETFEIEMNESDMMLETSMSDHST
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:18485873). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (PubMed:27509861). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:27120157, ECO:0000269|PubMed:27509861, ECO:0000269|PubMed:29033132}.
uniprot
proteins
mass_dalton
71656
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis. {ECO:0000269|PubMed:14657031}.
uniprot
proteins
protein_family
APC6/CDC16 family
uniprot
proteins
pubmed
14657031
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16364912
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18485873
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19668213
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25043029
uniprot
proteins
pubmed
26083744
uniprot
proteins
pubmed
27120157
uniprot
proteins
pubmed
27509861
uniprot
proteins
pubmed
29033132
uniprot
proteins
pubmed
34595750
uniprot
proteins
pubmed
7736578
uniprot
proteins
pubmed
9405394
uniprot
proteins
pubmed
9628895
uniprot
proteins
sequence_length
620
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:7736578}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:7736578}. Note=Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle. {ECO:0000269|PubMed:7736578}.
uniprot
proteins