Tdrkh
entrez
72634
canonical
uniprot
Q80VL1
canonical
ensembl
ENSMUSG00000041912
resolver
ensp
ENSMUSP00000041002
resolver
ensp
ENSMUSP00000129635
resolver
ensp
ENSMUSP00000142561
resolver
ensp
ENSMUSP00000142584
resolver
ensp
ENSMUSP00000143256
resolver
enst
ENSMUST00000045245
resolver
enst
ENSMUST00000166032
resolver
enst
ENSMUST00000196386
resolver
enst
ENSMUST00000197901
resolver
enst
ENSMUST00000200486
resolver
genesymbol
Tdrkh
resolver
genesymbol_syn
Tdrd2
resolver
uniprot
A0A0G2JE08
resolver
uniprot
A0A0G2JFP5
resolver
uniprot_entry
A0A0G2JE08_MOUSE
resolver
uniprot_entry
A0A0G2JFP5_MOUSE
resolver
uniprot_entry
TDRKH_MOUSE
resolver
amino_acid_sequence
MSTERTSWTNLSTIQKIALGLGIPASATVAYILYRRYRESREERLTFVGEDDIEIEMRVPQEAVKLIIGRQGANIKQLRKQTGARIDVDTEDVGDERVLLISGFPVQVCKAKAAIHQILTENTPVFEQLSVPQRSVGRIIGRGGETIRSICKASGAKITCDKESEGTLLLSRLIKISGTQKEVAAAKHLILEKVSEDEELRKRIAHSAETRVPRKQPISVRREEVTEPGGAGEAALWKNTNSSMGPATPLEVPLRKGGGDMVVVGPKEGSWEKPNDDSFQNSGAQSSPETSMFEIPSPDFSFHADEYLEVYVSASEHPNHFWIQIIGSRSLQLDKLVSEMTQHYENSLPEDLTVHVGDIVAAPLSTNGSWYRARVLGTLENGNLDLYFVDFGDNGDCALKDLRALRSDFLSLPFQAIECSLARIAPTGEEWEEEALDEFDRLTHCADWKPLVAKISSYVQTGISTWPKIYLYDTSDEKKLDIGLELVRKGYAVELPEDMEENRTVPNMLKDMATETDDSLASILTETKKSPEEMPHTLSCLSLSEAASMSGDDNLEDDLF
uniprot
proteins
function
FUNCTION: Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules. {ECO:0000269|PubMed:23714778}.
uniprot
proteins
mass_dalton
62134
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. {ECO:0000250|UniProtKB:Q9Y2W6}.
uniprot
proteins
protein_family
Tdrkh family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19584108
uniprot
proteins
pubmed
19918066
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23714778
uniprot
proteins
sequence_length
560
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Colocalizes with pi- and piP-bodies, a subset of the nuage which contains secondary piRNAs. Associated with mitochondria in the germline.
uniprot
proteins