Atp4a
entrez
11944
canonical
uniprot
Q64436
canonical
ensembl
ENSMUSG00000005553
resolver
ensp
ENSMUSP00000005692
resolver
ensp
ENSMUSP00000131964
resolver
enst
ENSMUST00000005692
resolver
enst
ENSMUST00000170371
resolver
genesymbol
Atp4a
resolver
uniprot
E9QNX7
resolver
uniprot
F6Z1V2
resolver
uniprot
Q91WH7
resolver
uniprot
Q9CV46
resolver
uniprot_entry
ATP4A_MOUSE
resolver
uniprot_entry
F6Z1V2_MOUSE
resolver
uniprot_entry
Q91WH7_MOUSE
resolver
uniprot_sec
E9QNX7
resolver
uniprot_sec
Q9CV46
resolver
amino_acid_sequence
MGKAENYELYSVELGSGPGGDMTAKMSKKKAGGGGGKKKEKLENMKKEMEINDHQLSVSELEQKYQTSATKGLKASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAVALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILSAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTAQGLVVSTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFVVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSINKFQLSIHTLEDPRDSRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRMPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFADYFTAMAQEGWFPLLCVGLRPQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSVFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVRCCPGSWWDQELYY
uniprot
proteins
ec_number
7.2.2.19
uniprot
proteins
function
FUNCTION: The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells (PubMed:7762614). Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (PubMed:7762614). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (PubMed:10764766). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (By similarity) (PubMed:7762614). {ECO:0000250|UniProtKB:P19156, ECO:0000269|PubMed:10764766, ECO:0000269|PubMed:7762614}.
uniprot
proteins
mass_dalton
114065
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIC subfamily
uniprot
proteins
pubmed
10764766
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7762614
uniprot
proteins
sequence_length
1034
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P20648}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in the apical canalicular membrane of parietal cells (By similarity). {ECO:0000250|UniProtKB:P20648}.
uniprot
proteins
transmembrane_region
TRANSMEM 98..118; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 299..318; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 331..348; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 783..802; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 813..833; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 854..876; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 929..948; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 963..981; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 997..1017; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins