Jagn1
entrez
67767
canonical
uniprot
Q5XKN4
canonical
ensembl
ENSMUSG00000051256
resolver
ensp
ENSMUSP00000098631
resolver
ensp
ENSMUSP00000145000
resolver
enst
ENSMUST00000101070
resolver
enst
ENSMUST00000204254
resolver
genesymbol
Jagn1
resolver
uniprot
A0A0N4SV89
resolver
uniprot
Q9CQ67
resolver
uniprot
Q9CX52
resolver
uniprot_entry
A0A0N4SV89_MOUSE
resolver
uniprot_entry
JAGN1_MOUSE
resolver
uniprot_sec
Q9CQ67
resolver
uniprot_sec
Q9CX52
resolver
amino_acid_sequence
MASRAGPRAAGTDGSDFQHRERVAMHYQMSVTLKYEIKKLIYVHLVIWLLLVAKMSVGHLRLLSHDQVAMPYQWEYPYLLSIVPSVLGLLSFPRNNISYLVLSMISMGLFSIAPLIYGSMEMFPAAQQLYRHGKAYRFLFGFSAVSVMYLVLVLAVQVHAWQLYYSKKLLDSWFTSTQEKKRK
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils. {ECO:0000269|PubMed:25129145, ECO:0000305}.
uniprot
proteins
mass_dalton
21102
uniprot
proteins
protein_family
Jagunal family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25129145
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8N5M9}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 97..117; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 138..158; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins