Cep19
entrez
66994
canonical
uniprot
Q9CQA8
canonical
ensembl
ENSMUSG00000035790
resolver
ensp
ENSMUSP00000046587
resolver
ensp
ENSMUSP00000110822
resolver
ensp
ENSMUSP00000126083
resolver
ensp
ENSMUSP00000243700
resolver
enst
ENSMUST00000042869
resolver
enst
ENSMUST00000115168
resolver
enst
ENSMUST00000169186
resolver
genesymbol
Cep19
resolver
uniprot_entry
CEP19_MOUSE
resolver
amino_acid_sequence
MKYIAKKCGVRFQPPAVILIYENETEGKSRQRIMPVRNFSKFSDCTRAAEQLKNNPRHKSYLEQVPLKQLEKLFVFLRGSLQGQSLAETMEQIRRETTIDPEEDLNKLDDKELAKRKSIMDELFEKNQKRKDDPTFVYDVEVEFPQDEQLLSCSWDTASVDDF
uniprot
proteins
function
FUNCTION: Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes. {ECO:0000250|UniProtKB:Q96LK0}.
uniprot
proteins
mass_dalton
19170
uniprot
proteins
protein_family
CEP19 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24268657
uniprot
proteins
sequence_length
163
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q96LK0}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q96LK0}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q96LK0}. Note=Associates with the mother centriole in early interphase. Localizes to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase. Localizes slightly apical to the subdistal appendage on the mother centriole, but below the distal appendage. {ECO:0000250|UniProtKB:Q96LK0}.
uniprot
proteins