Tial1
entrez
21843
canonical
uniprot
P70318
canonical
ensembl
ENSMUSG00000030846
resolver
ensp
ENSMUSP00000033135
resolver
ensp
ENSMUSP00000101833
resolver
ensp
ENSMUSP00000101835
resolver
ensp
ENSMUSP00000145933
resolver
enst
ENSMUST00000033135
resolver
enst
ENSMUST00000106226
resolver
enst
ENSMUST00000106228
resolver
genesymbol
Tial1
resolver
uniprot
D3Z3Y4
resolver
uniprot
F8WH51
resolver
uniprot
Q545C1
resolver
uniprot
Q921W2
resolver
uniprot_entry
D3Z3Y4_MOUSE
resolver
uniprot_entry
F8WH51_MOUSE
resolver
uniprot_entry
Q545C1_MOUSE
resolver
uniprot_entry
Q921W2_MOUSE
resolver
uniprot_entry
TIAR_MOUSE
resolver
amino_acid_sequence
MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSRRVNSSVGFSVLQHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQETNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASFPTQ
uniprot
proteins
function
FUNCTION: RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation (By similarity). Shows a preference for uridine-rich RNAs (By similarity). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (PubMed:11514562). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 (PubMed:17488725). Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) (By similarity). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (By similarity). May be involved in apoptosis (By similarity). {ECO:0000250|UniProtKB:Q01085, ECO:0000269|PubMed:11514562, ECO:0000269|PubMed:17488725}.
uniprot
proteins
mass_dalton
43389
uniprot
proteins
mutagenesis
MUTAGEN 117..121; /note="FVGDL->DVPDD: Impairs nuclear localization."; /evidence="ECO:0000269|PubMed:16278295"; MUTAGEN 156..160; /note="GYGFV->PDGDE: Impairs nuclear localization."; /evidence="ECO:0000269|PubMed:16278295"; MUTAGEN 225..229; /note="YCGGI->DRPPD: Abolishes nuclear export."; /evidence="ECO:0000269|PubMed:16278295"; MUTAGEN 258..264; /note="GYSFVRF->PDSDERD: Abolishes nuclear export."; /evidence="ECO:0000269|PubMed:16278295"; MUTAGEN 293..300; /note="KESPDMTK->RESPDMTR: No effect on nuclear localization."; /evidence="ECO:0000269|PubMed:16278295
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA. {ECO:0000250}.
uniprot
proteins
pubmed
11514562
uniprot
proteins
pubmed
16278295
uniprot
proteins
pubmed
17488725
uniprot
proteins
pubmed
19861488
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8871565
uniprot
proteins
sequence_length
392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16278295, ECO:0000269|PubMed:19861488}. Cytoplasm {ECO:0000269|PubMed:16278295, ECO:0000269|PubMed:19861488}. Cytoplasm, Stress granule {ECO:0000269|PubMed:19861488}. Cytolytic granule {ECO:0000250|UniProtKB:Q01085}. Note=Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (PubMed:16278295). Accumulates in cytoplasmic stress granules (SG) following cellular damage (By similarity). {ECO:0000250|UniProtKB:Q01085, ECO:0000269|PubMed:16278295}.
uniprot
proteins