Elob
entrez
67673
canonical
uniprot
P62869
canonical
ensembl
ENSMUSG00000055839
resolver
ensp
ENSMUSP00000066210
resolver
enst
ENSMUST00000069579
resolver
genesymbol
Elob
resolver
genesymbol_syn
Tceb2
resolver
uniprot
Q63529
resolver
uniprot
Q80W20
resolver
uniprot_entry
ELOB_MOUSE
resolver
uniprot_sec
Q63529
resolver
uniprot_sec
Q80W20
resolver
amino_acid_sequence
MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPEEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALRIEPFSSPPELPDVMKPQDSGGSANEQAVQ
uniprot
proteins
function
FUNCTION: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites (By similarity). Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (PubMed:27863225, PubMed:27863226). {ECO:0000250|UniProtKB:Q15370, ECO:0000269|PubMed:27863225, ECO:0000269|PubMed:27863226}.; FUNCTION: Core component of multiple cullin-2 and cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes), which mediate the ubiquitination of target proteins (PubMed:33590678, PubMed:35978186). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes (By similarity). Component the von Hippel-Lindau ubiquitination complex CBC(VHL) (By similarity). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The ECS(ASB9) complex mediates ubiquitination and degradation of CKB (By similarity). As part of a multisubunit ubiquitin ligase complex, polyubiquitinates monoubiquitinated POLR2A (By similarity). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (PubMed:33590678). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (By similarity). The ECS(ASB7) complex acts a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1 (By similarity). As part of the ECS(LRRC58) complex, mediates CDO1 ubiquitination and degradation, regulating cysteine catabolism (By similarity). {ECO:0000250|UniProtKB:Q15370, ECO:0000269|PubMed:33590678, ECO:0000269|PubMed:35978186}.
uniprot
proteins
mass_dalton
13170
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:33590678, ECO:0000269|PubMed:35978186}.
uniprot
proteins
protein_family
Elongin B family
uniprot
proteins
pubmed
10051596
uniprot
proteins
pubmed
11384984
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16498413
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23897481
uniprot
proteins
pubmed
27863225
uniprot
proteins
pubmed
27863226
uniprot
proteins
pubmed
28061330
uniprot
proteins
pubmed
33590678
uniprot
proteins
pubmed
35978186
uniprot
proteins
sequence_length
118
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:33590678}.
uniprot
proteins