PSME3
entrez
10197
canonical
uniprot
P61289
canonical
ensembl
ENSG00000131467
resolver
ensp
ENSP00000293362
resolver
ensp
ENSP00000409487
resolver
ensp
ENSP00000441682
resolver
ensp
ENSP00000466794
resolver
enst
ENST00000545225
resolver
genesymbol
HEL-S-283
resolver
genesymbol
PSME3
resolver
hgnc
HGNC:9570
resolver
uniprot
A8K9A3
resolver
uniprot
B3KQ25
resolver
uniprot
F6V8U1
resolver
uniprot
O35563
resolver
uniprot
P97373
resolver
uniprot
Q12920
resolver
uniprot
Q13172
resolver
uniprot
Q9BQD9
resolver
uniprot
V9HWJ8
resolver
uniprot_entry
B3KQ25_HUMAN
resolver
uniprot_entry
F6V8U1_HUMAN
resolver
uniprot_entry
PSME3_HUMAN
resolver
uniprot_entry
V9HWJ8_HUMAN
resolver
uniprot_sec
A8K9A3
resolver
uniprot_sec
O35563
resolver
uniprot_sec
P97373
resolver
uniprot_sec
Q12920
resolver
uniprot_sec
Q13172
resolver
uniprot_sec
Q9BQD9
resolver
amino_acid_sequence
MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY
uniprot
proteins
function
FUNCTION: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978). {ECO:0000269|PubMed:10835274, ECO:0000269|PubMed:11185562, ECO:0000269|PubMed:11432824, ECO:0000269|PubMed:15111123, ECO:0000269|PubMed:18309296, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:9325261}.
uniprot
proteins
mass_dalton
29506
uniprot
proteins
mutagenesis
MUTAGEN 188; /note="K->E,D,A,C,N,Q,H,F,S,I,P: Assembles into less stable hexamers/heptamers and therefore impairs specificity of activation of trypsin-like subunits of the proteasome."; /evidence="ECO:0000269|PubMed:11432824
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAP3K3 (By similarity). Phosphorylation at Ser-247 promotes its association with CCAR2. {ECO:0000250|UniProtKB:P61290, ECO:0000269|PubMed:25361978}.; PTM: Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1. {ECO:0000269|PubMed:23612972, ECO:0000269|Ref.9}.
uniprot
proteins
protein_family
PA28 family
uniprot
proteins
pubmed
10657252
uniprot
proteins
pubmed
10835274
uniprot
proteins
pubmed
11185562
uniprot
proteins
pubmed
11432824
uniprot
proteins
pubmed
12629132
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15111123
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
18309296
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
1968796
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21320693
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23612972
uniprot
proteins
pubmed
25361978
uniprot
proteins
pubmed
29934401
uniprot
proteins
pubmed
7545954
uniprot
proteins
pubmed
7951316
uniprot
proteins
pubmed
9325261
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10657252, ECO:0000269|PubMed:12629132}. Cytoplasm {ECO:0000250}. Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. {ECO:0000250}.
uniprot
proteins