Clic6
entrez
209195
canonical
uniprot
Q8BHB9
canonical
ensembl
ENSMUSG00000022949
resolver
ensp
ENSMUSP00000023670
resolver
enst
ENSMUST00000023670
resolver
genesymbol
Clic6
resolver
uniprot_entry
CLIC6_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is redox- and pH-regulated. Inhibited by IAA-94. {ECO:0000250|UniProtKB:Q96NY7}.
uniprot
proteins
amino_acid_sequence
MAEATEPKEVAPGSQGQPEGATIEGPGEPGAADLEGREASEEAAEAPRDLGAGVEARASGKEEGGCGQDEGTGGAQAQDPRTGPEAETPGASGAPGEAEAAERDPEGAIPQGAEEAPSAQQVQGMSSGLDSQGEAPEVPGDSRREPEDPTASEAGEEAESGQEAQGGGALGLQINPEVQGLAGDNMDTEAPAGGPLGSESEPQGGGESSPQPQDEAIEIVTTEIGGNESGELAGASAADAAGEGETLGKDGSEEAASEDARVDAHENGDQGKLQEETGEEEARPEPELKGPCEGAIQEKPPDGSLDGEEAKSTEHEEESQAELSNHLAEEPSVQGGEELGRVNGRRENGPALEEGDPGQEHDITLFVKAGYDGESIGNCPFSQRLFMILWLKGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDVNKIEEFLEEKLVPPRYPKLGTQHPESNSAGNDVFAKFSAFIKNTKKDANEIYEKNLLRALKKLDSYLNSPLPDEIDADSSEDVTVSQRKFLDGDELTLADCNLLPKLHIIKIVAKKYRDFEFPSEMTGIWRYLNNAYARDEFTNTCPADREIEHAYSDAAKRMK
uniprot
proteins
ec_number
1.8.-.-
uniprot
proteins
function
FUNCTION: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages (By similarity). May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). {ECO:0000250|UniProtKB:Q96NY7, ECO:0000250|UniProtKB:Q9N2G5, ECO:0000250|UniProtKB:Q9Y696}.
uniprot
proteins
mass_dalton
62886
uniprot
proteins
mutagenesis
MUTAGEN 383; /note="Q->A: Reduces solubility and disrupts the globular structure."; /evidence="ECO:0000269|PubMed:29720717
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q9N2G5}.
uniprot
proteins
protein_family
Chloride channel CLIC family
uniprot
proteins
pubmed
14597386
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29720717
uniprot
proteins
sequence_length
596
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 381..401; /note="Helical; Note=After insertion into the membrane"; /evidence="ECO:0000255
uniprot
proteins