Trpv3
entrez
246788
canonical
uniprot
Q8K424
canonical
ensembl
ENSMUSG00000043029
resolver
ensp
ENSMUSP00000053755
resolver
enst
ENSMUST00000049676
resolver
genesymbol
Trpv3
resolver
uniprot
Q5SV08
resolver
uniprot_entry
TRPV3_MOUSE
resolver
uniprot_sec
Q5SV08
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cannabinoid that binds to the vanilloid binding pocket (By similarity). Diphenylboronic anhydride induces pore dilation and enhances cation permeability by promoting the conversion to a homopentamer (By similarity). {ECO:0000250|UniProtKB:Q8NET8}.
uniprot
proteins
amino_acid_sequence
MNAHSKEMAPLMGKRTTAPGGNPVVLTEKRPADLTPTKKSAHFFLEIEGFEPNPTVTKTSPPIFSKPMDSNIRQCLSGNCDDMDSPQSPQDDVTETPSNPNSPSANLAKEEQRQKKKRLKKRIFAAVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSREIKEKPLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEIIVYNTNIDNRHEMLTLEPLHTLLHTKWKKFAKYMFFLSFCFYFFYNITLTLVSYYRPREDEDLPHPLALTHKMSWLQLLGRMFVLIWATCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFVQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYILFLLGFGVALASLIEKCSKDKKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSTYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVADEDFRLCLRINEVKWTEWKTHVSFLNEDPGPIRRTADLNKIQDSSRSNSKTTLYAFDELDEFPETSV
uniprot
proteins
function
FUNCTION: Non-selective calcium permeant cation channel (PubMed:12016205). It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius (By similarity). Activation exhibits an outward rectification (By similarity). The channel pore can dilate to provide permeability to larger cations (By similarity). May associate with TRPV1 and may modulate its activity (By similarity). Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity). {ECO:0000250|UniProtKB:Q8NET8, ECO:0000269|PubMed:12016205}.
uniprot
proteins
mass_dalton
90663
uniprot
proteins
protein_family
TRPV3 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
protein_family
TrpV subfamily
uniprot
proteins
pubmed
12016205
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
791
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8NET8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NET8}. Cytoplasm {ECO:0000250|UniProtKB:Q8NET8}. Lysosome {ECO:0000250|UniProtKB:Q8NET8}. Note=Targeted to lysosome for degradation in a SNX11-dependent manner. {ECO:0000250|UniProtKB:Q8NET8}.
uniprot
proteins
transmembrane_region
TRANSMEM 431..460; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:Q8NET8"; TRANSMEM 480..508; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:Q8NET8"; TRANSMEM 520..540; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:Q8NET8"; TRANSMEM 546..566; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:Q8NET8"; TRANSMEM 570..608; /note="Helical; Name=S5"; /evidence="ECO:0000250|UniProtKB:Q8NET8"; TRANSMEM 650..686; /note="Helical; Name=S6"; /evidence="ECO:0000250|UniProtKB:Q8NET8
uniprot
proteins