Bcar3
entrez
29815
canonical
uniprot
Q9QZK2
canonical
ensembl
ENSMUSG00000028121
resolver
ensp
ENSMUSP00000029766
resolver
genesymbol
Bcar3
resolver
genesymbol_syn
And34
resolver
uniprot
Q3TNC9
resolver
uniprot
Q3UP10
resolver
uniprot_entry
BCAR3_MOUSE
resolver
uniprot_sec
Q3TNC9
resolver
uniprot_sec
Q3UP10
resolver
amino_acid_sequence
MAAGKFASLPRNMPVNHQFPLASSMDLLSSKSPLAERRTDAYQDVSIHGTLPRKKKGPPSIRSCDNAGHSKSPRQSSPLTQDIIQENPLQDRKGENFIFRDPYLLDPTLEYVKFSKERHIMDRTPERLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLWCLEERYGTSPGRGREGSLAEGRPDVVKRLSLTTGSSIQAREHSLPRGNLLRNKEKSGSQPACLDHVQDRKALTLKAHQSESHLPIGCKLPPQSPSMDTSPCPSSPVFRTGSEPTLSPALVRRFSSDARTGEALRGSDSQLCPKPPPKPCKVPFLKTPPSPSPWLTSEANYCELNPAFAVGCDRGAKLPMQAHDSHEMLLTAKQNGPSGPRNSGINYMILDGDDQARHWDPLAVQTDEGQEDKTKFVPPLMETVSSFRPNDFESKLLPPENKPLETAMLKHAKELFTNHDARVIAQHMLSVDCKVARILEVSEDRKRSMGVSSGLELITLPHGRQLRLDIIERHNTMAIGIAVDILGCTGTLENRAGTLNKIIQVAVELKDAMGDLYAFSAIMKALEMPQITRLEKTWTALRHHYTQTAILYEKQLKPFSKILHEGRESTYVPASNVSVPLLMPLVTLMERQAVTFEGTDMWENNDESCEILLNHLATARFMAEASESYRMNAERILADFQPDEEMTEILRTEFQMRLLWGSKGAEVNQNERYDKFNQILTALSRKLEPPSGKQAEL
uniprot
proteins
function
FUNCTION: Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:12517963). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:10896938). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (PubMed:25499443). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (PubMed:25499443). Regulates EGF-induced DNA synthesis (By similarity). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (PubMed:19365570). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (PubMed:22801373). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (PubMed:22801373). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (PubMed:10896938). However, in a contrasting study, lacks GEF activity towards RAP1 (By similarity). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:O75815, ECO:0000269|PubMed:10896938, ECO:0000269|PubMed:12517963, ECO:0000269|PubMed:19365570, ECO:0000269|PubMed:22801373, ECO:0000269|PubMed:25499443}.
uniprot
proteins
mass_dalton
92263
uniprot
proteins
mutagenesis
MUTAGEN 733; /note="E->A: No effect on interaction with NEDD9."; /evidence="ECO:0000269|PubMed:19103205"; MUTAGEN 743; /note="R->A: Abolishes interaction with NEDD9."; /evidence="ECO:0000269|PubMed:19103205
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues. {ECO:0000269|PubMed:10438950}.
uniprot
proteins
pubmed
10438950
uniprot
proteins
pubmed
10896938
uniprot
proteins
pubmed
12517963
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19103205
uniprot
proteins
pubmed
19365570
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22801373
uniprot
proteins
pubmed
25499443
uniprot
proteins
sequence_length
820
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25499443}. Cell junction, focal adhesion {ECO:0000269|PubMed:22801373}. Note=Localization to focal adhesions depends on interaction with PTPRA. {ECO:0000269|PubMed:22801373}.
uniprot
proteins