Apoa5
entrez
140638
canonical
uniprot
Q9QUH3
canonical
ensembl
ENSRNOG00000018436
resolver
ensp
ENSRNOP00000024918
resolver
ensp
ENSRNOP00000094966
resolver
genesymbol
Apoa5
resolver
genesymbol_syn
Rap3
resolver
uniprot
Q5FVT8
resolver
uniprot_entry
APOA5_RAT
resolver
uniprot_sec
Q5FVT8
resolver
amino_acid_sequence
MAAVITWALALLSVFATVQARKSFWEYFGQNSQGKGMMGQQQKLAQESLKGSLEQDLYNMNNFLEKLGPLREPGKEPPRLAQDPEGIRKQLQQELEEVSTRLEPYMAAKHQQVGWNLEGLRQQLKPYTVELMEQVGLSVQDLQEQLRMVGKGTKAQLLGGVDEAMSLLQDMQSRVLHHTDRVKELFHPYAERLVTGIGHHVQELHRSVAPHAVASPARLSRCVQTLSHKLTRKAKDLHTSIQRNLDQLRDELSTFIRVSTDGADNRDSLDPQALSDEVRQRLQAFRHDTYLQIAAFTQAIDQETEEIQHQLAPPPPSHSAFAPELGHSDSNKALSRLQSRLDDLWEDIAYGLHDQGHSQNNPEGHSG
uniprot
proteins
function
FUNCTION: Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL (By similarity). May also be associated with chylomicrons (By similarity). Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages (By similarity). Binds heparin (By similarity). {ECO:0000250|UniProtKB:Q6Q788, ECO:0000250|UniProtKB:Q8C7G5}.
uniprot
proteins
mass_dalton
41427
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FAM20C in the extracellular medium. {ECO:0000250|UniProtKB:Q6Q788}.
uniprot
proteins
protein_family
Apolipoprotein A1/A4/E family
uniprot
proteins
pubmed
11577099
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6Q788}. Early endosome {ECO:0000250|UniProtKB:Q6Q788}. Late endosome {ECO:0000250|UniProtKB:Q6Q788}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q6Q788}. Note=In the presence of SORL1, internalized to early endosomes, sorted in a retrograde fashion to late endosomes, from which a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network. {ECO:0000250|UniProtKB:Q6Q788}.
uniprot
proteins