PLIN5
entrez
440503
canonical
uniprot
Q00G26
canonical
ensembl
ENSG00000214456
resolver
ensp
ENSP00000371272
resolver
ensp
ENSP00000575250
resolver
ensp
ENSP00000575253
resolver
ensp
ENSP00000575254
resolver
ensp
ENSP00000612414
resolver
enst
ENST00000381848
resolver
enst
ENST00000905191
resolver
enst
ENST00000905194
resolver
enst
ENST00000905195
resolver
enst
ENST00000942355
resolver
genesymbol
PLIN5
resolver
genesymbol_syn
LSDP5
resolver
genesymbol_syn
OXPAT
resolver
genesymbol_syn
PAT-1
resolver
hgnc
HGNC:33196
resolver
uniprot
A2RRC1
resolver
uniprot
Q6ZS68
resolver
uniprot_entry
PLIN5_HUMAN
resolver
uniprot_sec
A2RRC1
resolver
uniprot_sec
Q6ZS68
resolver
amino_acid_sequence
MSEEEAAQIPRSSVWEQDQQNVVQRVVALPLVRATCTAVCDVYSAAKDRHPLLGSACRLAENCVCGLTTRALDHAQPLLEHLQPQLATMNSLACRGLDKLEEKLPFLQQPSETVVTSAKDVVASSVTGVVDLARRGRRWSVELKRSVSHAVDVVLEKSEELVDHFLPMTEEELAALAAEAEGPEVGSVEDQRRQQGYFVRLGSLSARIRHLAYEHSVGKLRQSKHRAQDTLAQLQETLELIDHMQCGVTPTAPACPGKVHELWGEWGQRPPESRRRSQAELETLVLSRSLTQELQGTVEALESSVRGLPAGAQEKVAEVRRSVDALQTAFADARCFRDVPAAALAEGRGRVAHAHACVDELLELVVQAVPLPWLVGPFAPILVERPEPLPDLADLVDEVIGGPDPRWAHLDWPAQQRAWEAEHRDGSGNGDGDRMGVAGDICEQEPETPSCPVKHTLMPELDF
uniprot
proteins
function
FUNCTION: Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity). {ECO:0000250, ECO:0000269|PubMed:17234449}.
uniprot
proteins
mass_dalton
50791
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA. Phosphorylated on serine in skeletal muscle at rest or upon lipolytic stimulation (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Perilipin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17234449
uniprot
proteins
pubmed
23129790
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:17234449}. Cytoplasm {ECO:0000250|UniProtKB:Q8BVZ1}. Mitochondrion {ECO:0000250|UniProtKB:M0R7Z9}. Note=Lipid droplet surface-associated. Exchanges between lipid droplets and the cytoplasm. {ECO:0000250|UniProtKB:Q8BVZ1}.
uniprot
proteins