NIBAN2
entrez
64855
canonical
uniprot
Q96TA1
canonical
ensembl
ENSG00000136830
resolver
ensp
ENSP00000362409
resolver
ensp
ENSP00000362411
resolver
ensp
ENSP00000571189
resolver
genesymbol
NIBAN2
resolver
genesymbol_syn
C9orf88
resolver
genesymbol_syn
FAM129B
resolver
hgnc
HGNC:25282
resolver
uniprot
Q4LE55
resolver
uniprot
Q5VVW6
resolver
uniprot
Q5VVW7
resolver
uniprot
Q9BUS2
resolver
uniprot
Q9NT35
resolver
uniprot_entry
NIBA2_HUMAN
resolver
uniprot_sec
Q4LE55
resolver
uniprot_sec
Q5VVW6
resolver
uniprot_sec
Q5VVW7
resolver
uniprot_sec
Q9BUS2
resolver
uniprot_sec
Q9NT35
resolver
amino_acid_sequence
MGDVLSTHLDDARRQHIAEKTGKILTEFLQFYEDQYGVALFNSMRHEIEGTGLPQAQLLWRKVPLDERIVFSGNLFQHQEDSKKWRNRFSLVPHNYGLVLYENKAAYERQVPPRAVINSAGYKILTSVDQYLELIGNSLPGTTAKSGSAPILKCPTQFPLILWHPYARHYYFCMMTEAEQDKWQAVLQDCIRHCNNGIPEDSKVEGPAFTDAIRMYRQSKELYGTWEMLCGNEVQILSNLVMEELGPELKAELGPRLKGKPQERQRQWIQISDAVYHMVYEQAKARFEEVLSKVQQVQPAMQAVIRTDMDQIITSKEHLASKIRAFILPKAEVCVRNHVQPYIPSILEALMVPTSQGFTEVRDVFFKEVTDMNLNVINEGGIDKLGEYMEKLSRLAYHPLKMQSCYEKMESLRLDGLQQRFDVSSTSVFKQRAQIHMREQMDNAVYTFETLLHQELGKGPTKEELCKSIQRVLERVLKKYDYDSSSVRKRFFREALLQISIPFLLKKLAPTCKSELPRFQELIFEDFARFILVENTYEEVVLQTVMKDILQAVKEAAVQRKHNLYRDSMVMHNSDPNLHLLAEGAPIDWGEEYSNSGGGGSPSPSTPESATLSEKRRRAKQVVSVVQDEEVGLPFEASPESPPPASPDGVTEIRGLLAQGLRPESPPPAGPLLNGAPAGESPQPKAAPEASSPPASPLQHLLPGKAVDLGPPKPSDQETGEQVSSPSSHPALHTTTEDSAGVQTEF
uniprot
proteins
function
FUNCTION: May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. {ECO:0000269|PubMed:19362540, ECO:0000269|PubMed:21148485}.
uniprot
proteins
mass_dalton
84138
uniprot
proteins
mutagenesis
MUTAGEN 641; /note="S->A: Loss of melanoma cell invasion; when associated with A-646; A-665; A-681; A-679 and A-683."; /evidence="ECO:0000269|PubMed:19362540"; MUTAGEN 641; /note="S->D,E: Promotes melanoma cell invasion; when associated with D/E-633; D/E-652; D/E-668; D/E-679 and D/E-683."; /evidence="ECO:0000269|PubMed:19362540"; MUTAGEN 646; /note="S->A: Loss of melanoma cell invasion; when associated with A-641; A-665; A-681; A-679 and A-683."; /evidence="ECO:0000269|PubMed:19362540"; MUTAGEN 646; /note="S->D,E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-652; D/E-668; D/E-679 and D/E-683."; /evidence="ECO:0000269|PubMed:19362540"; MUTAGEN 665; /note="S->A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-681; A-679 and A-683."; /evidence="ECO:0000269|PubMed:19362540"; MUTAGEN 665; /note="S->D,E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-668; D/E-679 and D/E-683."; /evidence="ECO:0000269|PubMed:19362540"; MUTAGEN 681; /note="S->A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-665; A-679 and A-683."; /evidence="ECO:0000269|PubMed:19362540"; MUTAGEN 681; /note="S->D,E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-652; D/E-679 and D/E-683."; /evidence="ECO:0000269|PubMed:19362540"; MUTAGEN 692; /note="S->A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-665; A-668 and A-683."; /evidence="ECO:0000269|PubMed:19362540"; MUTAGEN 692; /note="S->D,E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-652; D/E-668 and D/E-683."; /evidence="ECO:0000269|PubMed:19362540"; MUTAGEN 696; /note="S->A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-665; A-668 and A-679."; /evidence="ECO:0000269|PubMed:19362540"; MUTAGEN 696; /note="S->D,E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-652; D/E-668 and D/E-679."; /evidence="ECO:0000269|PubMed:19362540
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane. {ECO:0000269|PubMed:19362540}.; PTM: As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases. {ECO:0000269|PubMed:21148485}.
uniprot
proteins
protein_family
Niban family
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19362540
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21148485
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
25807930
uniprot
proteins
sequence_length
746
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell junction, adherens junction. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation.
uniprot
proteins