Cckbr
entrez
25706
canonical
uniprot
P30553
canonical
ensembl
ENSRNOG00000017679
resolver
ensembl
ENSRNOG00055024046
resolver
ensembl
ENSRNOG00060017559
resolver
ensembl
ENSRNOG00065031807
resolver
ensp
ENSRNOP00000024077
resolver
ensp
ENSRNOP00055033623
resolver
ensp
ENSRNOP00060024241
resolver
ensp
ENSRNOP00065045060
resolver
enst
ENSRNOT00000024077
resolver
enst
ENSRNOT00055041320
resolver
enst
ENSRNOT00060030034
resolver
enst
ENSRNOT00065054794
resolver
genesymbol
Cckbr
resolver
uniprot
G3V8A8
resolver
uniprot_entry
G3V8A8_RAT
resolver
uniprot_entry
GASR_RAT
resolver
amino_acid_sequence
MELLKLNRSVQGPGPGSGSSLCRPGVSLLNSSSAGNLSCDPPRIRGTGTRELEMAIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTMVQPVGPRVLQCMHRWPSARVQQTWSVLLLLLLFFIPGVVIAVAYGLISRELYLGLHFDGENDSETQSRARNQGGLPGGAAPGPVHQNGGCRPVTSVAGEDSDGCCVQLPRSRLEMTTLTTPTPGPVPGPRPNQAKLLAKKRVVRMLLVIVLLFFLCWLPVYSVNTWRAFDGPGAQRALSGAPISFIHLLSYVSACVNPLVYCFMHRRFRQACLDTCARCCPRPPRARPQPLPDEDPPTPSIASLSRLSYTTISTLGPG
uniprot
proteins
function
FUNCTION: Receptor for the peptide hormones gastrin and cholecystokinin (CCK). Expressed throughout the central nervous system, where it modulates processes such as anxiety, analgesia, arousal and neuroleptic activity. Couples to both GNAI1 and GNAQ signaling pathways, but not to GNAS (By similarity). Upon gastrin activation, reduces glucose absorption in intestinal epithelial cells by down-regulating SGLT1 and GLUT2 expression through suppression of the PI3K/Akt/eIF4B pathway (By similarity). In the kidney, decreases SGLT2 expression under high-glucose conditions via ERK/NF-kappa-B signaling (By similarity). {ECO:0000250|UniProtKB:P32239, ECO:0000250|UniProtKB:P56481}.
uniprot
proteins
mass_dalton
48957
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1528881
uniprot
proteins
sequence_length
452
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P32239}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P32239}.
uniprot
proteins
transmembrane_region
TRANSMEM 54..77; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P32239"; TRANSMEM 89..107; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P32239"; TRANSMEM 127..147; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P32239"; TRANSMEM 170..187; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P32239"; TRANSMEM 215..235; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P32239"; TRANSMEM 339..358; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P32239"; TRANSMEM 379..397; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P32239
uniprot
proteins