Smap2
entrez
69780
canonical
uniprot
Q7TN29
canonical
ensembl
ENSMUSG00000032870
resolver
ensp
ENSMUSP00000035800
resolver
genesymbol
Smap2
resolver
genesymbol_syn
Smap1l
resolver
uniprot
Q3U798
resolver
uniprot_entry
SMAP2_MOUSE
resolver
uniprot_sec
Q3U798
resolver
amino_acid_sequence
MTGKSVKDVDRYQAVLANLLLEEDNKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKANRLYEAYLPETFRRPQIDPAVEGFIRDKYEKKKYMDRSLDINVLRKEKDDKWKRGNEPAPEKKMEPVVFEKVKMPQKKEDAQLPRKSSPKSAAPVMDLLGLDAPVACSIANSKTSNALEKDLDLLASVPSPSSVSRKAVGSMPTAGSAGSVPENLNLFPEPGSKSEETGKKQLSKDSILSLYGSQTPQMPAQAMFMAPAQMAYPTAYPSFPGVTPPNSIMGGMVPPPVGMVAQPGASGMLTPMAMPAGYMGGMQASMMGVPNGMMTTQQAGYMASMAAMPQTVYGVQPAQQLQWNLTQMTQQMAGMNFYGANGMMNYGQSMGGGNGQAANQTLSPQMWK
uniprot
proteins
function
FUNCTION: GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network. {ECO:0000269|PubMed:16571680}.
uniprot
proteins
mass_dalton
46578
uniprot
proteins
mutagenesis
MUTAGEN 56; /note="R->Q: Loss of GTPase activation."; /evidence="ECO:0000269|PubMed:16571680"; MUTAGEN 187..191; /note="LLGLD->AAAAA: Loss of interaction with clathrin heavy chains; when associated with 212-AAA-214."; /evidence="ECO:0000269|PubMed:16571680"; MUTAGEN 212..214; /note="DLL->AAA: Loss of interaction with clathrin heavy chains; when associated with 187-AAAAA-191."; /evidence="ECO:0000269|PubMed:16571680
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16571680
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
428
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16571680}. Note=Detected in multiple foci throughout the cytoplasm and in juxtanuclear structures.
uniprot
proteins