NTN1
entrez
9423
canonical
uniprot
O95631
canonical
ensembl
ENSG00000065320
resolver
ensp
ENSP00000173229
resolver
ensp
ENSP00000632912
resolver
enst
ENST00000173229
resolver
enst
ENST00000962853
resolver
genesymbol
NTN1
resolver
genesymbol_syn
NTN1L
resolver
hgnc
HGNC:8029
resolver
uniprot
E9KL51
resolver
uniprot_entry
NET1_HUMAN
resolver
uniprot_sec
E9KL51
resolver
amino_acid_sequence
MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSVEEPEDCDSYCKASKGKLKINMKKYCKKDYAVQIHILKADKAGDWWKFTVNIISVYKQGTSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPDQSGIVADKSSLVIQWRDTWARRLRKFQQREKKGKCKKA
uniprot
proteins
disease_involvement
DISEASE: Mirror movements 4 (MRMV4) [MIM:618264]: A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. MRMV4 inheritance is autosomal dominant. {ECO:0000269|PubMed:28945198, ECO:0000269|PubMed:38314870}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335). {ECO:0000269|PubMed:15343335, ECO:0000269|PubMed:28483977}.
uniprot
proteins
mass_dalton
67748
uniprot
proteins
pubmed
15343335
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19196994
uniprot
proteins
pubmed
20736409
uniprot
proteins
pubmed
28483977
uniprot
proteins
pubmed
28945198
uniprot
proteins
pubmed
38314870
uniprot
proteins
pubmed
9950216
uniprot
proteins
sequence_length
604
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28945198}. Cytoplasm {ECO:0000269|PubMed:28945198}. Note=Mainly secreted. {ECO:0000269|PubMed:28945198}.
uniprot
proteins