ADRM1
entrez
11047
canonical
uniprot
Q16186
canonical
ensembl
ENSG00000130706
resolver
ensp
ENSP00000253003
resolver
ensp
ENSP00000478877
resolver
ensp
ENSP00000480756
resolver
ensp
ENSP00000576370
resolver
ensp
ENSP00000576371
resolver
ensp
ENSP00000576372
resolver
ensp
ENSP00000576373
resolver
ensp
ENSP00000576375
resolver
ensp
ENSP00000576376
resolver
ensp
ENSP00000576378
resolver
ensp
ENSP00000576384
resolver
ensp
ENSP00000576385
resolver
ensp
ENSP00000576389
resolver
ensp
ENSP00000583494
resolver
ensp
ENSP00000616063
resolver
ensp
ENSP00000616064
resolver
ensp
ENSP00000760873
resolver
ensp
ENSP00000792850
resolver
enst
ENST00000253003
resolver
enst
ENST00000491935
resolver
enst
ENST00000620230
resolver
enst
ENST00000906311
resolver
enst
ENST00000906312
resolver
enst
ENST00000906313
resolver
enst
ENST00000906314
resolver
enst
ENST00000906316
resolver
enst
ENST00000906317
resolver
enst
ENST00000906319
resolver
enst
ENST00000906326
resolver
enst
ENST00000906327
resolver
enst
ENST00000906330
resolver
enst
ENST00000913435
resolver
enst
ENST00000946004
resolver
enst
ENST00000946005
resolver
genesymbol
ADRM1
resolver
genesymbol_syn
GP110
resolver
hgnc
HGNC:15759
resolver
uniprot
A0A087WX59
resolver
uniprot
A0PKB1
resolver
uniprot
Q96FJ7
resolver
uniprot
Q9H1P2
resolver
uniprot_entry
A0A087WX59_HUMAN
resolver
uniprot_entry
ADRM1_HUMAN
resolver
uniprot_sec
A0PKB1
resolver
uniprot_sec
Q96FJ7
resolver
uniprot_sec
Q9H1P2
resolver
amino_acid_sequence
MTTSGALFPSLVPGSRGASNKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGNVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKPEQKEGDTKDKKDEEEDMSLD
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Within the complex, functions as a proteasomal ubiquitin receptor (PubMed:18497817). Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). {ECO:0000269|PubMed:16815440, ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:16990800, ECO:0000269|PubMed:17139257, ECO:0000269|PubMed:18497817, ECO:0000269|PubMed:24752541, ECO:0000269|PubMed:25702870, ECO:0000269|PubMed:25702872}.
uniprot
proteins
mass_dalton
42153
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by UBE3C in response to proteotoxic stress. {ECO:0000269|PubMed:24811749, ECO:0000269|PubMed:31375563}.
uniprot
proteins
protein_family
ADRM1 family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16815440
uniprot
proteins
pubmed
16906146
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
16990800
uniprot
proteins
pubmed
17139257
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
18497817
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20471946
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24752541
uniprot
proteins
pubmed
24811749
uniprot
proteins
pubmed
25702870
uniprot
proteins
pubmed
25702872
uniprot
proteins
pubmed
27396824
uniprot
proteins
pubmed
31375563
uniprot
proteins
pubmed
8033103
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16990800}. Nucleus {ECO:0000269|PubMed:16990800}.
uniprot
proteins