PRSS37
entrez
136242
canonical
uniprot
A4D1T9
canonical
ensembl
ENSG00000165076
resolver
ensp
ENSP00000297767
resolver
ensp
ENSP00000414461
resolver
enst
ENST00000350549
resolver
enst
ENST00000438520
resolver
genesymbol
PRSS37
resolver
genesymbol_syn
TRYX2
resolver
hgnc
HGNC:29211
resolver
uniprot
B2RPB5
resolver
uniprot_entry
PRS37_HUMAN
resolver
uniprot_sec
B2RPB5
resolver
amino_acid_sequence
MKYVFYLGVLAGTFFFADSSVQKEDPAPYLVYLKSHFNPCVGVLIKPSWVLAPAHCYLPNLKVMLGNFKSRVRDGTEQTINPIQIVRYWNYSHSAPQDDLMLIKLAKPAMLNPKVQPLTLATTNVRPGTVCLLSGLDWSQENSGRHPDLRQNLEAPVMSDRECQKTEQGKSHRNSLCVKFVKVFSRIFGEVAVATVICKDKLQGIEVGHFMGGDVGIYTNVYKYVSWIENTAKDK
uniprot
proteins
disease_involvement
DISEASE: Note=Patients with unexplained male infertility (UMI) show a decrease in the number of sperm cells compared to fertile men (PubMed:27649891). Sperm exhibit also abnormal activation of the proacrosin/acrosin system and premature proteolysis of ADAM2 (PubMed:27649891). {ECO:0000269|PubMed:27649891}.
uniprot
proteins
function
FUNCTION: Plays a role in male fertility (By similarity). May have a role in sperm migration or binding to zona-intact eggs (By similarity). Involved in the activation of the proacrosin/acrosin system (PubMed:27649891). {ECO:0000250|UniProtKB:Q9DAA4, ECO:0000269|PubMed:27649891}.
uniprot
proteins
mass_dalton
26445
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
27649891
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:27649891}. Secreted {ECO:0000305}.
uniprot
proteins