MOGAT1
entrez
116255
canonical
uniprot
Q96PD6
canonical
ensembl
ENSG00000124003
resolver
ensp
ENSP00000406674
resolver
enst
ENST00000446656
resolver
genesymbol
MOGAT1
resolver
genesymbol_syn
DC2
resolver
genesymbol_syn
DGAT2L1
resolver
hgnc
HGNC:18210
resolver
uniprot
Q6IEE5
resolver
uniprot_entry
MOGT1_HUMAN
resolver
uniprot_sec
Q6IEE5
resolver
amino_acid_sequence
MKVEFAPLNIQLARRLQTVAVLQWVLKYLLLGPMSIGITVMLIIHNYLFLYIPYLMWLYFDWHTPERGGRRSSWIKNWTLWKHFKDYFPIHLIKTQDLDPSHNYIFGFHPHGIMAVGAFGNFSVNYSDFKDLFPGFTSYLHVLPLWFWCPVFREYVMSVGLVSVSKKSVSYMVSKEGGGNISVIVLGGAKESLDAHPGKFTLFIRQRKGFVKIALTHGASLVPVVSFGENELFKQTDNPEGSWIRTVQNKLQKIMGFALPLFHARGVFQYNFGLMTYRKAIHTVVGRPIPVRQTLNPTQEQIEELHQTYMEELRKLFEEHKGKYGIPEHETLVLK
uniprot
proteins
ec_number
2.3.1.22
uniprot
proteins
function
FUNCTION: Involved in glycerolipid synthesis and lipid metabolism. Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol, mainly at the sn-1 or sn-3 positions. It uses both sn-2-monoacylglycerol (2-acylglycerol) and sn-1-monoacylglycerol (1-acyl-sn-glycerol) equally well as substrates, and uses sn-3-monoacylglycerol (3-acyl-sn-glycerol) with lower efficiency. Probably not involved in absorption of dietary fat in the small intestine. {ECO:0000250|UniProtKB:Q91ZV4}.
uniprot
proteins
mass_dalton
38812
uniprot
proteins
pathway_participation
PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis. {ECO:0000250|UniProtKB:Q91ZV4}.
uniprot
proteins
protein_family
Diacylglycerol acyltransferase family
uniprot
proteins
pubmed
11481335
uniprot
proteins
pubmed
12621063
uniprot
proteins
pubmed
14970677
uniprot
proteins
pubmed
15815621
uniprot
proteins
sequence_length
335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q91ZV4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91ZV4}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 132..152; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins