CCL17
entrez
6361
canonical
uniprot
Q92583
canonical
ensembl
ENSG00000102970
resolver
ensp
ENSP00000219244
resolver
ensp
ENSP00000480147
resolver
enst
ENST00000219244
resolver
enst
ENST00000616880
resolver
genesymbol
CCL17
resolver
genesymbol_syn
SCYA17
resolver
genesymbol_syn
TARC
resolver
hgnc
HGNC:10615
resolver
uniprot
A0N0Q9
resolver
uniprot
Q2M287
resolver
uniprot_entry
CCL17_HUMAN
resolver
uniprot_sec
A0N0Q9
resolver
uniprot_sec
Q2M287
resolver
amino_acid_sequence
MAPLKMLALVTLLLGASLQHIHAARGTNVGRECCLEYFKGAIPLRKLKTWYQTSEDCSRDAIVFVTVQGRAICSDPNNKRVKNAVKYLQSLERS
uniprot
proteins
function
FUNCTION: Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes (PubMed:8702936, PubMed:9169480). Acts by binding to CCR4 at T-cell surface (PubMed:10540332, PubMed:9169480). Mediates GM-CSF/CSF2-driven pain and inflammation (PubMed:27525438). In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation (By similarity). Plays a role in wound healing, mainly by inducing fibroblast migration into the wound (By similarity). {ECO:0000250|UniProtKB:Q9WUZ6, ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:27525438, ECO:0000269|PubMed:8702936, ECO:0000269|PubMed:9169480}.
uniprot
proteins
mass_dalton
10507
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
10540332
uniprot
proteins
pubmed
12832759
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
27525438
uniprot
proteins
pubmed
29871928
uniprot
proteins
pubmed
8702936
uniprot
proteins
pubmed
9169480
uniprot
proteins
pubmed
9521068
uniprot
proteins
sequence_length
94
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27525438, ECO:0000269|PubMed:29871928, ECO:0000269|PubMed:8702936}.
uniprot
proteins