GPR52
entrez
9293
canonical
uniprot
Q9Y2T5
canonical
ensembl
ENSG00000203737
resolver
ensp
ENSP00000356658
resolver
enst
ENST00000367685
resolver
genesymbol
GPR52
resolver
hgnc
HGNC:4508
resolver
uniprot
F2YGU0
resolver
uniprot
O75654
resolver
uniprot
Q4VBL6
resolver
uniprot
Q6ISM0
resolver
uniprot_entry
F2YGU0_HUMAN
resolver
uniprot_entry
GPR52_HUMAN
resolver
uniprot_sec
O75654
resolver
uniprot_sec
Q4VBL6
resolver
uniprot_sec
Q6ISM0
resolver
amino_acid_sequence
MNESRWTEWRILNMSSGIVNVSERHSCPLGFGHYSVVDVCIFETVVIVLLTFLIIAGNLTVIFVFHCAPLLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLLHYSTGVHESLTCQVFGYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIILIWIYSCLIFLPSFFGWGKPGYHGDIFEWCATSWLTSAYFTGFIVCLLYAPAAFVVCFTYFHIFKICRQHTKEINDRRARFPSHEVDSSRETGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNCVIYSLSNSVFRLGLRRLSETMCTSCMCVKDQEAQEPKPRKRANSCSI
uniprot
proteins
function
FUNCTION: Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228). {ECO:0000269|PubMed:24587241, ECO:0000269|PubMed:25738228}.
uniprot
proteins
mass_dalton
41354
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
24587241
uniprot
proteins
pubmed
25738228
uniprot
proteins
pubmed
9931487
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 45..65; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 266..286; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 297..317; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins