Gpr50
entrez
14765
canonical
uniprot
O88495
canonical
ensembl
ENSMUSG00000056380
resolver
ensp
ENSMUSP00000064608
resolver
enst
ENSMUST00000070449
resolver
genesymbol
Gpr50
resolver
uniprot
Q3V1S8
resolver
uniprot_entry
MTR1L_MOUSE
resolver
uniprot_sec
Q3V1S8
resolver
amino_acid_sequence
MATVPKSNMGPTKAVPTPFGCIGCKLPKPDYPPALIIFMFCAMVITVVVDLIGNSMVILAVTKNKKLRNSGNIFVASLSVADMLVAIYPYPLMLYAMSVGGWDLSQLQCQMVGLVTGLSVVGSIFNITAIAINRYCYICHSLQYKRIFSLRNTCIYLVVTWVMTVLAVLPNMYIGTIEYDPRTYTCIFNYVNNPAFTVTIVCIHFVLPLIIVGYCYTKIWIKVLAARDPAGQNPDNQFAEVRNFLTMFVIFLLFAVCWCPVNVLTVLVAVIPKEMAGKIPNWLYLAAYCIAYFNSCLNAIIYGILNESFRREYWTIFHAMRHPILFISHLISDIRETWETRALTRARVRARDQVREQERARACVAVEGTPRNVRNVLLPGDASAPHSDRASVRPKPQTRSTSVYRKPASIHHKSISGHPKSASVYPKPASSVHCKPASVHFKPASVHFKGDSVYFKGDTVHYRAASKLVTSHRISAGPSTSHPTSMAGYIKSGTSHPATTTVDYLEPATTSHSVLTAVDLPEVSASHCLEMTSTGHLRADISASVLPSVPFELAATPPDTTAIPIASGDYRKVVLIDDDSDDSDCSDEMAV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration (PubMed:17957037, PubMed:19699797). Promotes self-renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways (PubMed:25689717). Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalization (PubMed:21858214). Also plays a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration (PubMed:29572483). {ECO:0000269|PubMed:17957037, ECO:0000269|PubMed:19699797, ECO:0000269|PubMed:21858214, ECO:0000269|PubMed:25689717, ECO:0000269|PubMed:29572483}.
uniprot
proteins
mass_dalton
65130
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17957037
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19699797
uniprot
proteins
pubmed
21858214
uniprot
proteins
pubmed
25689717
uniprot
proteins
pubmed
29572483
uniprot
proteins
pubmed
9933574
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19699797, ECO:0000269|PubMed:29572483}; Multi-pass membrane protein. Postsynaptic density {ECO:0000269|PubMed:19699797}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 73..93; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 152..172; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 197..217; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 248..268; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 282..302; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins