Elp3
entrez
74195
canonical
uniprot
Q9CZX0
canonical
ensembl
ENSMUSG00000022031
resolver
ensp
ENSMUSP00000022609
resolver
ensp
ENSMUSP00000153462
resolver
genesymbol
Elp3
resolver
uniprot
Q8C2K2
resolver
uniprot
Q8R369
resolver
uniprot_entry
ELP3_MOUSE
resolver
uniprot_sec
Q8C2K2
resolver
uniprot_sec
Q8R369
resolver
amino_acid_sequence
MRQKRKGDLSPAELMMLTIGDVIKQLVEAHEQGKDVDLNKMKTKTAAKYGLASQPRLVDIIAAVPPHYRKILIPKLKAKPVRTASGIAVVAVMCKPHRCPHISFTGNICIYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMALPEEYRDYFIRSLHDALSGHTSNNIHEAIKYSERSFTKCVGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGHTVKAACESFHLAKDSGFKVVTHMMPDLPNVGLERDIEQFIEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYRSYSPSDLIELVARILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELAFARMKDLGIQCRDVRTREVGIQEIHHRVRPYQVELVRRDYVANGGWETFLSYEDPDQDILIGLLRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQHQGFGMLLMEEAERIAREEHGSGKMAVISGVGTRNYYRKIGYRLQGPYMVKMLK
uniprot
proteins
ec_number
2.3.1.311
uniprot
proteins
function
FUNCTION: Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidence suggests that ELP3 primarily acts as a tRNA acetyltransferase (By similarity). Not a major acetyltransferase of tubulin (PubMed:22153374). Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337). Required for acetylation of GJA1 in the developing cerebral cortex (PubMed:28507509). {ECO:0000250|UniProtKB:D5VRB9, ECO:0000250|UniProtKB:Q9H9T3, ECO:0000269|PubMed:19185337, ECO:0000269|PubMed:22153374, ECO:0000269|PubMed:22854966, ECO:0000269|PubMed:28507509}.
uniprot
proteins
mass_dalton
62385
uniprot
proteins
pathway_participation
PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. {ECO:0000250|UniProtKB:Q9H9T3}.
uniprot
proteins
post_translational_modification
PTM: Tyrosine-phosphorylated. Also serine/threonine-phosphorylated. {ECO:0000250|UniProtKB:Q9H9T3}.
uniprot
proteins
protein_family
ELP3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19185337
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22153374
uniprot
proteins
pubmed
22854966
uniprot
proteins
pubmed
27476491
uniprot
proteins
pubmed
28507509
uniprot
proteins
pubmed
29415125
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19185337}. Nucleus {ECO:0000250|UniProtKB:Q9H9T3}.
uniprot
proteins