ARPC2
entrez
10109
canonical
uniprot
O15144
canonical
ensembl
ENSG00000163466
resolver
ensp
ENSP00000295685
resolver
ensp
ENSP00000327137
resolver
ensp
ENSP00000526723
resolver
ensp
ENSP00000526724
resolver
ensp
ENSP00000526725
resolver
ensp
ENSP00000526726
resolver
ensp
ENSP00000526732
resolver
ensp
ENSP00000613756
resolver
enst
ENST00000295685
resolver
enst
ENST00000315717
resolver
enst
ENST00000856664
resolver
enst
ENST00000856665
resolver
enst
ENST00000856666
resolver
enst
ENST00000856667
resolver
enst
ENST00000856673
resolver
enst
ENST00000943697
resolver
genesymbol
ARPC2
resolver
genesymbol_syn
ARC34
resolver
hgnc
HGNC:705
resolver
uniprot
A0A024R457
resolver
uniprot
Q53R19
resolver
uniprot
Q92801
resolver
uniprot
Q9P1D4
resolver
uniprot_entry
ARPC2_HUMAN
resolver
uniprot_entry
Q53R19_HUMAN
resolver
uniprot_sec
A0A024R457
resolver
uniprot_sec
Q92801
resolver
uniprot_sec
Q9P1D4
resolver
amino_acid_sequence
MILLEVNNRIIEETLALKFENAAAGNKPEAVEVTFADFDGVLYHISNPNGDKTKVMVSISLKFYKELQAHGADELLKRVYGSFLVNPESGYNVSLLYDLENLPASKDSIVHQAGMLKRNCFASVFEKYFQFQEEGKEGENRAVIHYRDDETMYVESKKDRVTVVFSTVFKDDDDVVIGKVFMQEFKEGRRASHTAPQVLFSHREPPLELKDTDAAVGDNIGYITFVLFPRHTNASARDNTINLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRARPDAEKKEMKTITGKTFSSR
uniprot
proteins
function
FUNCTION: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.
uniprot
proteins
mass_dalton
34333
uniprot
proteins
protein_family
ARPC2 family
uniprot
proteins
pubmed
11741539
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29925947
uniprot
proteins
pubmed
32128961
uniprot
proteins
pubmed
8812419
uniprot
proteins
pubmed
9230079
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9230079}. Cell projection {ECO:0000269|PubMed:9230079}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q9CVB6}. Nucleus {ECO:0000269|PubMed:29925947}.
uniprot
proteins