LONP2
entrez
83752
canonical
uniprot
Q86WA8
canonical
ensembl
ENSG00000102910
resolver
ensp
ENSP00000285737
resolver
ensp
ENSP00000415983
resolver
ensp
ENSP00000445426
resolver
ensp
ENSP00000788482
resolver
ensp
ENSP00000788484
resolver
ensp
ENSP00000797030
resolver
enst
ENST00000416006
resolver
genesymbol
LONP2
resolver
genesymbol_syn
LONP
resolver
hgnc
HGNC:20598
resolver
uniprot
B7ZKL7
resolver
uniprot
E7EN44
resolver
uniprot
Q0D2H6
resolver
uniprot
Q8N3B9
resolver
uniprot
Q8NCE9
resolver
uniprot
Q96K43
resolver
uniprot_entry
E7EN44_HUMAN
resolver
uniprot_entry
LONP2_HUMAN
resolver
uniprot_sec
B7ZKL7
resolver
uniprot_sec
Q0D2H6
resolver
uniprot_sec
Q8N3B9
resolver
uniprot_sec
Q8NCE9
resolver
uniprot_sec
Q96K43
resolver
amino_acid_sequence
MSSVSPIQIPSRLPLLLTHEGVLLPGSTMRTSVDSARNLQLVRSRLLKGTSLQSTILGVIPNTPDPASDAQDLPPLHRIGTAALAVQVVGSNWPKPHYTLLITGLCRFQIVQVLKEKPYPIAEVEQLDRLEEFPNTCKMREELGELSEQFYKYAVQLVEMLDMSVPAVAKLRRLLDSLPREALPDILTSIIRTSNKEKLQILDAVSLEERFKMTIPLLVRQIEGLKLLQKTRKPKQDDDKRVIAIRPIRRITHISGTLEDEDEDEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKKRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPAALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQVTTLDIITRYTREAGVRSLDRKLGAICRAVAVKVAEGQHKEAKLDRSDVTEREGCREHILEDEKPESISDTTDLALPPEMPILIDFHALKDILGPPMYEMEVSQRLSQPGVAIGLAWTPLGGEIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYQLTNAFGSFDLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKQVIIPRRNEKDLEGIPGNVRQDLSFVTASCLDEVLNAAFDGGFTVKTRPGLLNSKL
uniprot
proteins
ec_number
3.4.21.53
uniprot
proteins
function
FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. {ECO:0000255|HAMAP-Rule:MF_03121, ECO:0000269|PubMed:22002062}.
uniprot
proteins
mass_dalton
94617
uniprot
proteins
mutagenesis
MUTAGEN 743; /note="S->A: Reduces degradation of self-processed forms of TYSND1. Loss of ACOX1-processing."; /evidence="ECO:0000269|PubMed:18281296, ECO:0000269|PubMed:22002062"; MUTAGEN 850..852; /note="Missing: Loss of peroxisomal localization."; /evidence="ECO:0000269|PubMed:18281296
uniprot
proteins
protein_family
Peptidase S16 family
uniprot
proteins
pubmed
14561759
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18281296
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22002062
uniprot
proteins
pubmed
22814378
uniprot
proteins
sequence_length
852
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000255|HAMAP-Rule:MF_03121, ECO:0000269|PubMed:14561759, ECO:0000269|PubMed:18281296, ECO:0000269|PubMed:22002062}.
uniprot
proteins