Siglec1
entrez
20612
canonical
uniprot
Q62230
canonical
ensembl
ENSMUSG00000027322
resolver
ensp
ENSMUSP00000028794
resolver
ensp
ENSMUSP00000105856
resolver
enst
ENSMUST00000028794
resolver
genesymbol
Siglec1
resolver
genesymbol_syn
Sa
resolver
genesymbol_syn
Sn
resolver
uniprot
D3YVZ3
resolver
uniprot
D3YVZ4
resolver
uniprot
G3X8X6
resolver
uniprot
O55216
resolver
uniprot
Q62228
resolver
uniprot
Q62229
resolver
uniprot_entry
G3X8X6_MOUSE
resolver
uniprot_entry
SN_MOUSE
resolver
uniprot_sec
D3YVZ3
resolver
uniprot_sec
D3YVZ4
resolver
uniprot_sec
O55216
resolver
uniprot_sec
Q62228
resolver
uniprot_sec
Q62229
resolver
amino_acid_sequence
MCVLFSLLLLASVFSLGQTTWGVSSPKNVQGLSGSCLLIPCIFSYPADVPVSNGITAIWYYDYSGKRQVVIHSGDPKLVDKRFRGRAELMGNMDHKVCNLLLKDLKPEDSGTYNFRFEISDSNRWLDVKGTTVTVTTDPSPPTITIPEELREGMERNFNCSTPYLCLQEKQVSLQWRGQDPTHSVTSSFQSLEPTGVYHQTTLHMALSWQDHGRTLLCQFSLGAHSSRKEVYLQVPHAPKGVEILLSSSGRNILPGDPVTLTCRVNSSYPAVSAVQWARDGVNLGVTGHVLRLFSAAWNDSGAYTCQATNDMGSLVSSPLSLHVFMAEVKMNPAGPVLENETVTLLCSTPKEAPQELRYSWYKNHILLEDAHASTLHLPAVTRADTGFYFCEVQNAQGSERSSPLSVVVRYPPLTPDLTTFLETQAGLVGILHCSVVSEPLATVVLSHGGLTLASNSGENDFNPRFRISSAPNSLRLEIRDLQPADSGEYTCLAVNSLGNSTSSLDFYANVARLLINPSAEVVEGQAVTLSCRSGLSPAPDTRFSWYLNGALLLEGSSSSLLLPAASSTDAGSYYCRTQAGPNTSGPSLPTVLTVFYPPRKPTFTARLDLDTSGVGDGRRGILLCHVDSDPPAQLRLLHKGHVVATSLPSRCGSCSQRTKVSRTSNSLHVEIQKPVLEDEGVYLCEASNTLGNSSAAASFNAKATVLVITPSNTLREGTEANLTCNVNQEVAVSPANFSWFRNGVLWTQGSLETVRLQPVARTDAAVYACRLLTEDGAQLSAPVVLSVLYAPDPPKLSALLDVGQGHMAVFICTVDSYPLAHLSLFRGDHLLATNLEPQRPSHGRIQAKATANSLQLEVRELGLVDSGNYHCEATNILGSANSSLFFQVRGAWVQVSPSPELREGQAVVLSCQVPTGVSEGTSYSWYQDGRPLQESTSSTLRIAAISLRQAGAYHCQAQAPDTAIASLAAPVSLHVSYTPRHVTLSALLSTDPERLGHLVCSVQSDPPAQLQLFHRNRLVASTLQGADELAGSNPRLHVTVLPNELRLQIHFPELEDDGTYTCEASNTLGQASAAADFDAQAVRVTVWPNATVQEGQQVNLTCLVWSTHQDSLSYTWYKGGQQLLGARSITLPSVKVLDATSYRCGVGLPGHAPHLSRPVTLDVLHAPRNLRLTYLLETQGRQLALVLCTVDSRPPAQLTLSHGDQLVASSTEASVPNTLRLELQDPRPSNEGLYSCSAHSPLGKANTSLELLLEGVRVKMNPSGSVPEGEPVTVTCEDPAALSSALYAWFHNGHWLQEGPASSLQFLVTTRAHAGAYFCQVHDTQGTRSSRPASLQILYAPRDAVLSSFRDSRTRLMVVIQCTVDSEPPAEMVLSHNGKVLAASHERHSSASGIGHIQVARNALRLQVQDVTLGDGNTYVCTAQNTLGSISTTQRLLTETDIRVTAEPGLDVPEGTALNLSCLLPGGSGPTGNSSFTWFWNRHRLHSAPVPTLSFTPVVRAQAGLYHCRADLPTGATTSAPVMLRVLYPPKTPTLIVFVEPQGGHQGILDCRVDSEPLAILTLHRGSQLVASNQLHDAPTKPHIRVTAPPNALRVDIEELGPSNQGEYVCTASNTLGSASASAYFGTRALHQLQLFQRLLWVLGFLAGFLCLLLGLVAYHTWRKKSSTKLNEDENSAEMATKKNTIQEEVVAAL
uniprot
proteins
function
FUNCTION: Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response (PubMed:24788876). Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs) (PubMed:26370074). In turn, enhances macrophage-to-T-cell transmission of several viruses including murine leukemia virus (PubMed:26370074). Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q9BZZ2, ECO:0000269|PubMed:24788876, ECO:0000269|PubMed:26370074}.
uniprot
proteins
mass_dalton
182979
uniprot
proteins
mutagenesis
MUTAGEN 21; /note="W->Q: Loss of sialic acid binding."; /evidence="ECO:0000269|PubMed:10393093"; MUTAGEN 116; /note="R->A: Loss of sialic acid binding."; /evidence="ECO:0000269|PubMed:10393093"; MUTAGEN 116; /note="R->L: 10-fold loss in affinity to sialic acid."; /evidence="ECO:0000269|PubMed:10393093
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
SIGLEC (sialic acid binding Ig-like lectin) family
uniprot
proteins
pubmed
10393093
uniprot
proteins
pubmed
11238599
uniprot
proteins
pubmed
12737821
uniprot
proteins
pubmed
15364954
uniprot
proteins
pubmed
15488769
uniprot
proteins
pubmed
16449664
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
2050106
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24788876
uniprot
proteins
pubmed
26370074
uniprot
proteins
pubmed
7533044
uniprot
proteins
pubmed
7925291
uniprot
proteins
pubmed
9383289
uniprot
proteins
pubmed
9660955
uniprot
proteins
sequence_length
1695
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 1640..1660; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins