SLC6A14
entrez
11254
canonical
uniprot
Q9UN76
canonical
ensembl
ENSG00000268104
resolver
ensp
ENSP00000470801
resolver
enst
ENST00000598581
resolver
genesymbol
SLC6A14
resolver
hgnc
HGNC:11047
resolver
uniprot
B2R8J1
resolver
uniprot
Q5H942
resolver
uniprot_entry
B2R8J1_HUMAN
resolver
uniprot_entry
S6A14_HUMAN
resolver
uniprot_sec
Q5H942
resolver
amino_acid_sequence
MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAIFIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCCRPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE
uniprot
proteins
disease_involvement
DISEASE: Note=Genetic variations in SLC6A14 may be associated with obesity in some populations, as shown by significant differences in allele frequencies between obese and non-obese individuals. {ECO:0000269|PubMed:14660737, ECO:0000269|PubMed:14660752}.
uniprot
proteins
function
FUNCTION: Amino acid transporter that plays an important role in the absorption of amino acids in the intestinal tract. Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner (PubMed:10446133). Transports non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (PubMed:18599538). Can also transport carnitine, butirylcarnitine and propionylcarnitine coupled to the transmembrane gradients of Na(+) and Cl(-) (PubMed:17855766). {ECO:0000250|UniProtKB:Q9JMA9, ECO:0000269|PubMed:10446133, ECO:0000269|PubMed:17855766, ECO:0000269|PubMed:18599538}.
uniprot
proteins
mass_dalton
72153
uniprot
proteins
protein_family
SLC6A14 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
10446133
uniprot
proteins
pubmed
14660737
uniprot
proteins
pubmed
14660752
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17855766
uniprot
proteins
pubmed
18599538
uniprot
proteins
sequence_length
642
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:10446133}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q9JMA9}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..65; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 72..92; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 235..255; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 261..281; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 315..335; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 348..368; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 399..419; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 450..477; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 480..500; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 528..548; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 563..583; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins