HLA-B
entrez
3106
canonical
uniprot
P01889
canonical
ensembl
ENSG00000232126
resolver
ensembl
ENSG00000234745
resolver
ensp
ENSP00000388208
resolver
ensp
ENSP00000399168
resolver
ensp
ENSP00000512717
resolver
ensp
ENSP00000512718
resolver
ensp
ENSP00000512719
resolver
ensp
ENSP00000512720
resolver
enst
ENST00000412585
resolver
enst
ENST00000450871
resolver
enst
ENST00000696559
resolver
enst
ENST00000696560
resolver
enst
ENST00000696561
resolver
enst
ENST00000696562
resolver
genesymbol
HLA-B
resolver
genesymbol_syn
HLAB
resolver
hgnc
HGNC:4932
resolver
uniprot
A0A2I6Q7B5
resolver
uniprot
A0A5S8K785
resolver
uniprot
B0V0B8
resolver
uniprot
D9J307
resolver
uniprot
E5FQ95
resolver
uniprot
G3GN01
resolver
uniprot
O02862
resolver
uniprot
O02956
resolver
uniprot
O02957
resolver
uniprot
O02960
resolver
uniprot
O19555
resolver
uniprot
O19556
resolver
uniprot
O19595
resolver
uniprot
O19615
resolver
uniprot
O19624
resolver
uniprot
O19625
resolver
uniprot
O19627
resolver
uniprot
O19641
resolver
uniprot
O19651
resolver
uniprot
O19675
resolver
uniprot
O19692
resolver
uniprot
O19758
resolver
uniprot
O19779
resolver
uniprot
O19783
resolver
uniprot
O46702
resolver
uniprot
O62897
resolver
uniprot
O62901
resolver
uniprot
O62915
resolver
uniprot
O62917
resolver
uniprot
O62919
resolver
uniprot
O77933
resolver
uniprot
O77959
resolver
uniprot
O78053
resolver
uniprot
O78138
resolver
uniprot
O78160
resolver
uniprot
O78163
resolver
uniprot
O78172
resolver
uniprot
O78173
resolver
uniprot
O78180
resolver
uniprot
O78217
resolver
uniprot
O95730
resolver
uniprot
O98140
resolver
uniprot
P01890
resolver
uniprot
P03989
resolver
uniprot
P10317
resolver
uniprot
P10318
resolver
uniprot
P10319
resolver
uniprot
P10320
resolver
uniprot
P18463
resolver
uniprot
P18464
resolver
uniprot
P18465
resolver
uniprot
P19373
resolver
uniprot
P30460
resolver
uniprot
P30461
resolver
uniprot
P30462
resolver
uniprot
P30463
resolver
uniprot
P30464
resolver
uniprot
P30465
resolver
uniprot
P30466
resolver
uniprot
P30467
resolver
uniprot
P30468
resolver
uniprot
P30469
resolver
uniprot
P30470
resolver
uniprot
P30471
resolver
uniprot
P30472
resolver
uniprot
P30473
resolver
uniprot
P30474
resolver
uniprot
P30475
resolver
uniprot
P30476
resolver
uniprot
P30477
resolver
uniprot
P30478
resolver
uniprot
P30479
resolver
uniprot
P30480
resolver
uniprot
P30481
resolver
uniprot
P30482
resolver
uniprot
P30483
resolver
uniprot
P30484
resolver
uniprot
P30485
resolver
uniprot
P30486
resolver
uniprot
P30487
resolver
uniprot
P30488
resolver
uniprot
P30489
resolver
uniprot
P30490
resolver
uniprot
P30491
resolver
uniprot
P30492
resolver
uniprot
P30493
resolver
uniprot
P30494
resolver
uniprot
P30495
resolver
uniprot
P30496
resolver
uniprot
P30497
resolver
uniprot
P30498
resolver
uniprot
P30513
resolver
uniprot
P30685
resolver
uniprot
P79489
resolver
uniprot
P79490
resolver
uniprot
P79496
resolver
uniprot
P79504
resolver
uniprot
P79523
resolver
uniprot
P79524
resolver
uniprot
P79542
resolver
uniprot
P79555
resolver
uniprot
Q04826
resolver
uniprot
Q08136
resolver
uniprot
Q29633
resolver
uniprot
Q29636
resolver
uniprot
Q29638
resolver
uniprot
Q29661
resolver
uniprot
Q29665
resolver
uniprot
Q29678
resolver
uniprot
Q29679
resolver
uniprot
Q29681
resolver
uniprot
Q29693
resolver
uniprot
Q29695
resolver
uniprot
Q29697
resolver
uniprot
Q29718
resolver
uniprot
Q29742
resolver
uniprot
Q29749
resolver
uniprot
Q29762
resolver
uniprot
Q29764
resolver
uniprot
Q29829
resolver
uniprot
Q29836
resolver
uniprot
Q29842
resolver
uniprot
Q29845
resolver
uniprot
Q29846
resolver
uniprot
Q29847
resolver
uniprot
Q29848
resolver
uniprot
Q29850
resolver
uniprot
Q29851
resolver
uniprot
Q29852
resolver
uniprot
Q29854
resolver
uniprot
Q29855
resolver
uniprot
Q29857
resolver
uniprot
Q29858
resolver
uniprot
Q29861
resolver
uniprot
Q29924
resolver
uniprot
Q29925
resolver
uniprot
Q29933
resolver
uniprot
Q29935
resolver
uniprot
Q29936
resolver
uniprot
Q29940
resolver
uniprot
Q29953
resolver
uniprot
Q29961
resolver
uniprot
Q29982
resolver
uniprot
Q30173
resolver
uniprot
Q30198
resolver
uniprot
Q31603
resolver
uniprot
Q31610
resolver
uniprot
Q31612
resolver
uniprot
Q31613
resolver
uniprot
Q546L8
resolver
uniprot
Q546M4
resolver
uniprot
Q5JP37
resolver
uniprot
Q5QT24
resolver
uniprot
Q5RIP1
resolver
uniprot
Q5SRJ2
resolver
uniprot
Q5TK76
resolver
uniprot
Q5TK77
resolver
uniprot
Q860I4
resolver
uniprot
Q861B5
resolver
uniprot
Q8HWF0
resolver
uniprot
Q8MGQ3
resolver
uniprot
Q8MHN4
resolver
uniprot
Q8SNC5
resolver
uniprot
Q95343
resolver
uniprot
Q95344
resolver
uniprot
Q95365
resolver
uniprot
Q95369
resolver
uniprot
Q95392
resolver
uniprot
Q95HA3
resolver
uniprot
Q95HA8
resolver
uniprot
Q95HM9
resolver
uniprot
Q95IA6
resolver
uniprot
Q95IB8
resolver
uniprot
Q95IH5
resolver
uniprot
Q95J00
resolver
uniprot
Q96IT9
resolver
uniprot
Q9BCM6
resolver
uniprot
Q9BCM7
resolver
uniprot
Q9BCM8
resolver
uniprot
Q9BD06
resolver
uniprot
Q9BD38
resolver
uniprot
Q9BD43
resolver
uniprot
Q9GIL3
resolver
uniprot
Q9GIM3
resolver
uniprot
Q9GIX1
resolver
uniprot
Q9GIY5
resolver
uniprot
Q9GIZ0
resolver
uniprot
Q9GIZ9
resolver
uniprot
Q9GJ00
resolver
uniprot
Q9GJ17
resolver
uniprot
Q9GJ20
resolver
uniprot
Q9GJ23
resolver
uniprot
Q9GJ31
resolver
uniprot
Q9GJF0
resolver
uniprot
Q9GJM7
resolver
uniprot
Q9MX21
resolver
uniprot
Q9MY37
resolver
uniprot
Q9MY42
resolver
uniprot
Q9MY43
resolver
uniprot
Q9MY61
resolver
uniprot
Q9MY75
resolver
uniprot
Q9MY78
resolver
uniprot
Q9MY79
resolver
uniprot
Q9MY84
resolver
uniprot
Q9MY92
resolver
uniprot
Q9MY93
resolver
uniprot
Q9MY94
resolver
uniprot
Q9MYB8
resolver
uniprot
Q9MYC3
resolver
uniprot
Q9MYC7
resolver
uniprot
Q9MYF4
resolver
uniprot
Q9MYG1
resolver
uniprot
Q9TP35
resolver
uniprot
Q9TP36
resolver
uniprot
Q9TP37
resolver
uniprot
Q9TP95
resolver
uniprot
Q9TPQ7
resolver
uniprot
Q9TPQ9
resolver
uniprot
Q9TPR2
resolver
uniprot
Q9TPR4
resolver
uniprot
Q9TPS6
resolver
uniprot
Q9TPT2
resolver
uniprot
Q9TPT4
resolver
uniprot
Q9TPT6
resolver
uniprot
Q9TPV2
resolver
uniprot
Q9TQG1
resolver
uniprot
Q9TQH3
resolver
uniprot
Q9TQH6
resolver
uniprot
Q9TQH7
resolver
uniprot
Q9TQH8
resolver
uniprot
Q9TQH9
resolver
uniprot
Q9TQM2
resolver
uniprot
Q9TQN4
resolver
uniprot
Q9TQN6
resolver
uniprot
Q9UQS8
resolver
uniprot
Q9UQT0
resolver
uniprot_entry
A0A5S8K785_HUMAN
resolver
uniprot_entry
D9J307_HUMAN
resolver
uniprot_entry
E5FQ95_HUMAN
resolver
uniprot_entry
HLAB_HUMAN
resolver
uniprot_sec
A0A2I6Q7B5
resolver
uniprot_sec
B0V0B8
resolver
uniprot_sec
G3GN01
resolver
uniprot_sec
O02862
resolver
uniprot_sec
O02956
resolver
uniprot_sec
O02957
resolver
uniprot_sec
O02960
resolver
uniprot_sec
O19555
resolver
uniprot_sec
O19556
resolver
uniprot_sec
O19595
resolver
uniprot_sec
O19615
resolver
uniprot_sec
O19624
resolver
uniprot_sec
O19625
resolver
uniprot_sec
O19627
resolver
uniprot_sec
O19641
resolver
uniprot_sec
O19651
resolver
uniprot_sec
O19675
resolver
uniprot_sec
O19692
resolver
uniprot_sec
O19758
resolver
uniprot_sec
O19779
resolver
uniprot_sec
O19783
resolver
uniprot_sec
O46702
resolver
uniprot_sec
O62897
resolver
uniprot_sec
O62901
resolver
uniprot_sec
O62915
resolver
uniprot_sec
O62917
resolver
uniprot_sec
O62919
resolver
uniprot_sec
O77933
resolver
uniprot_sec
O77959
resolver
uniprot_sec
O78053
resolver
uniprot_sec
O78138
resolver
uniprot_sec
O78160
resolver
uniprot_sec
O78163
resolver
uniprot_sec
O78172
resolver
uniprot_sec
O78173
resolver
uniprot_sec
O78180
resolver
uniprot_sec
O78217
resolver
uniprot_sec
O95730
resolver
uniprot_sec
O98140
resolver
uniprot_sec
P01890
resolver
uniprot_sec
P03989
resolver
uniprot_sec
P10317
resolver
uniprot_sec
P10318
resolver
uniprot_sec
P10319
resolver
uniprot_sec
P10320
resolver
uniprot_sec
P18463
resolver
uniprot_sec
P18464
resolver
uniprot_sec
P18465
resolver
uniprot_sec
P19373
resolver
uniprot_sec
P30460
resolver
uniprot_sec
P30461
resolver
uniprot_sec
P30462
resolver
uniprot_sec
P30463
resolver
uniprot_sec
P30464
resolver
uniprot_sec
P30465
resolver
uniprot_sec
P30466
resolver
uniprot_sec
P30467
resolver
uniprot_sec
P30468
resolver
uniprot_sec
P30469
resolver
uniprot_sec
P30470
resolver
uniprot_sec
P30471
resolver
uniprot_sec
P30472
resolver
uniprot_sec
P30473
resolver
uniprot_sec
P30474
resolver
uniprot_sec
P30475
resolver
uniprot_sec
P30476
resolver
uniprot_sec
P30477
resolver
uniprot_sec
P30478
resolver
uniprot_sec
P30479
resolver
uniprot_sec
P30480
resolver
uniprot_sec
P30481
resolver
uniprot_sec
P30482
resolver
uniprot_sec
P30483
resolver
uniprot_sec
P30484
resolver
uniprot_sec
P30485
resolver
uniprot_sec
P30486
resolver
uniprot_sec
P30487
resolver
uniprot_sec
P30488
resolver
uniprot_sec
P30489
resolver
uniprot_sec
P30490
resolver
uniprot_sec
P30491
resolver
uniprot_sec
P30492
resolver
uniprot_sec
P30493
resolver
uniprot_sec
P30494
resolver
uniprot_sec
P30495
resolver
uniprot_sec
P30496
resolver
uniprot_sec
P30497
resolver
uniprot_sec
P30498
resolver
uniprot_sec
P30513
resolver
uniprot_sec
P30685
resolver
uniprot_sec
P79489
resolver
uniprot_sec
P79490
resolver
uniprot_sec
P79496
resolver
uniprot_sec
P79504
resolver
uniprot_sec
P79523
resolver
uniprot_sec
P79524
resolver
uniprot_sec
P79542
resolver
uniprot_sec
P79555
resolver
uniprot_sec
Q04826
resolver
uniprot_sec
Q08136
resolver
uniprot_sec
Q29633
resolver
uniprot_sec
Q29636
resolver
uniprot_sec
Q29638
resolver
uniprot_sec
Q29661
resolver
uniprot_sec
Q29665
resolver
uniprot_sec
Q29678
resolver
uniprot_sec
Q29679
resolver
uniprot_sec
Q29681
resolver
uniprot_sec
Q29693
resolver
uniprot_sec
Q29695
resolver
uniprot_sec
Q29697
resolver
uniprot_sec
Q29718
resolver
uniprot_sec
Q29742
resolver
uniprot_sec
Q29749
resolver
uniprot_sec
Q29762
resolver
uniprot_sec
Q29764
resolver
uniprot_sec
Q29829
resolver
uniprot_sec
Q29836
resolver
uniprot_sec
Q29842
resolver
uniprot_sec
Q29845
resolver
uniprot_sec
Q29846
resolver
uniprot_sec
Q29847
resolver
uniprot_sec
Q29848
resolver
uniprot_sec
Q29850
resolver
uniprot_sec
Q29851
resolver
uniprot_sec
Q29852
resolver
uniprot_sec
Q29854
resolver
uniprot_sec
Q29855
resolver
uniprot_sec
Q29857
resolver
uniprot_sec
Q29858
resolver
uniprot_sec
Q29861
resolver
uniprot_sec
Q29924
resolver
uniprot_sec
Q29925
resolver
uniprot_sec
Q29933
resolver
uniprot_sec
Q29935
resolver
uniprot_sec
Q29936
resolver
uniprot_sec
Q29940
resolver
uniprot_sec
Q29953
resolver
uniprot_sec
Q29961
resolver
uniprot_sec
Q29982
resolver
uniprot_sec
Q30173
resolver
uniprot_sec
Q30198
resolver
uniprot_sec
Q31603
resolver
uniprot_sec
Q31610
resolver
uniprot_sec
Q31612
resolver
uniprot_sec
Q31613
resolver
uniprot_sec
Q546L8
resolver
uniprot_sec
Q546M4
resolver
uniprot_sec
Q5JP37
resolver
uniprot_sec
Q5QT24
resolver
uniprot_sec
Q5RIP1
resolver
uniprot_sec
Q5SRJ2
resolver
uniprot_sec
Q5TK76
resolver
uniprot_sec
Q5TK77
resolver
uniprot_sec
Q860I4
resolver
uniprot_sec
Q861B5
resolver
uniprot_sec
Q8HWF0
resolver
uniprot_sec
Q8MGQ3
resolver
uniprot_sec
Q8MHN4
resolver
uniprot_sec
Q8SNC5
resolver
uniprot_sec
Q95343
resolver
uniprot_sec
Q95344
resolver
uniprot_sec
Q95365
resolver
uniprot_sec
Q95369
resolver
uniprot_sec
Q95392
resolver
uniprot_sec
Q95HA3
resolver
uniprot_sec
Q95HA8
resolver
uniprot_sec
Q95HM9
resolver
uniprot_sec
Q95IA6
resolver
uniprot_sec
Q95IB8
resolver
uniprot_sec
Q95IH5
resolver
uniprot_sec
Q95J00
resolver
uniprot_sec
Q96IT9
resolver
uniprot_sec
Q9BCM6
resolver
uniprot_sec
Q9BCM7
resolver
uniprot_sec
Q9BCM8
resolver
uniprot_sec
Q9BD06
resolver
uniprot_sec
Q9BD38
resolver
uniprot_sec
Q9BD43
resolver
uniprot_sec
Q9GIL3
resolver
uniprot_sec
Q9GIM3
resolver
uniprot_sec
Q9GIX1
resolver
uniprot_sec
Q9GIY5
resolver
uniprot_sec
Q9GIZ0
resolver
uniprot_sec
Q9GIZ9
resolver
uniprot_sec
Q9GJ00
resolver
uniprot_sec
Q9GJ17
resolver
uniprot_sec
Q9GJ20
resolver
uniprot_sec
Q9GJ23
resolver
uniprot_sec
Q9GJ31
resolver
uniprot_sec
Q9GJF0
resolver
uniprot_sec
Q9GJM7
resolver
uniprot_sec
Q9MX21
resolver
uniprot_sec
Q9MY37
resolver
uniprot_sec
Q9MY42
resolver
uniprot_sec
Q9MY43
resolver
uniprot_sec
Q9MY61
resolver
uniprot_sec
Q9MY75
resolver
uniprot_sec
Q9MY78
resolver
uniprot_sec
Q9MY79
resolver
uniprot_sec
Q9MY84
resolver
uniprot_sec
Q9MY92
resolver
uniprot_sec
Q9MY93
resolver
uniprot_sec
Q9MY94
resolver
uniprot_sec
Q9MYB8
resolver
uniprot_sec
Q9MYC3
resolver
uniprot_sec
Q9MYC7
resolver
uniprot_sec
Q9MYF4
resolver
uniprot_sec
Q9MYG1
resolver
uniprot_sec
Q9TP35
resolver
uniprot_sec
Q9TP36
resolver
uniprot_sec
Q9TP37
resolver
uniprot_sec
Q9TP95
resolver
uniprot_sec
Q9TPQ7
resolver
uniprot_sec
Q9TPQ9
resolver
uniprot_sec
Q9TPR2
resolver
uniprot_sec
Q9TPR4
resolver
uniprot_sec
Q9TPS6
resolver
uniprot_sec
Q9TPT2
resolver
uniprot_sec
Q9TPT4
resolver
uniprot_sec
Q9TPT6
resolver
uniprot_sec
Q9TPV2
resolver
uniprot_sec
Q9TQG1
resolver
uniprot_sec
Q9TQH3
resolver
uniprot_sec
Q9TQH6
resolver
uniprot_sec
Q9TQH7
resolver
uniprot_sec
Q9TQH8
resolver
uniprot_sec
Q9TQH9
resolver
uniprot_sec
Q9TQM2
resolver
uniprot_sec
Q9TQN4
resolver
uniprot_sec
Q9TQN6
resolver
uniprot_sec
Q9UQS8
resolver
uniprot_sec
Q9UQT0
resolver
amino_acid_sequence
MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSLTA
uniprot
proteins
disease_involvement
DISEASE: Stevens-Johnson syndrome (SJS) [MIM:608579]: A rare blistering mucocutaneous disease that share clinical and histopathologic features with toxic epidermal necrolysis. Both disorders are characterized by high fever, malaise, and a rapidly developing blistering exanthema of macules and target-like lesions accompanied by mucosal involvement. Stevens-Johnson syndrome is a milder disease characterized by destruction and detachment of the skin epithelium and mucous membranes involving less than 10% of the body surface area. Ocular symptoms include ulcerative conjunctivitis, keratitis, iritis, uveitis and sometimes blindness. It can be caused by a severe adverse reaction to particular types of medication, although Mycoplasma infections may induce some cases. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. Increased susceptibility to Stevens-Johnson syndrome is conferred by allele B*15:02. {ECO:0000269|PubMed:15057820}.; DISEASE: Spondyloarthropathy 1 (SPDA1) [MIM:106300]: A chronic rheumatic disease with multifactorial inheritance. It includes a spectrum of related disorders comprising ankylosing spondylitis, a subset of psoriatic arthritis, reactive arthritis (e.g. Reiter syndrome), arthritis associated with inflammatory bowel disease and undifferentiated spondyloarthropathy. These disorders may occur simultaneously or sequentially in the same patient, probably representing various phenotypic expressions of the same disease. Ankylosing spondylitis is the form of rheumatoid arthritis affecting the spine and is considered the prototype of seronegative spondyloarthropathies. It produces pain and stiffness as a result of inflammation of the sacroiliac, intervertebral, and costovertebral joints. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. A restricted number of HLA-B*27 subtypes can be associated with ankylosing spondylitis and other B*27-related diseases, and an elevated frequency of the B*27:02 allele in ankylosing spondylitis patients is identified. The allele B*27:07 seems to have a protective role in some populations because it was found only in the healthy controls. {ECO:0000269|PubMed:15603872}.; DISEASE: Note=There is evidence that HLA-B*51 is associated with susceptibility to Behcet disease (BD). However, it is not certain whether HLA-B*51 itself or a closely linked gene is responsible for susceptibility. The world distribution of HLA-B*51 in healthy people corresponds to the global distribution of BD; in Southern hemisphere countries (Africa, South Pacific, etc.) and in some parts of Europe, the prevalence of HLA-B*51 in healthy people is low or null, corresponding to a low prevalence of BD. The wide variation that exists in the relative risk of HLA-B*51 would support other nongenetic risk factors. {ECO:0000269|PubMed:23291587}.; DISEASE: Note=The presence of allele B*57:01 is associated with increased susceptibility to abacavir hypersensitivity [MIM:142830] in HIV-1 patients. {ECO:0000269|PubMed:11888582}.; DISEASE: Note=Allele group B*08 is associated with increased susceptibility to rheumatoid arthritis, where affected individuals have antibodies to cyclic citrullinated peptide (anti-CCP-positive rheumatoid arthritis). {ECO:0000269|PubMed:22286218}.
uniprot
proteins
function
FUNCTION: Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:23209413, PubMed:25808313, PubMed:29531227, PubMed:9620674). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:18991276, PubMed:7743181). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:24600035, PubMed:29531227, PubMed:9620674). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227). {ECO:0000269|PubMed:18991276, ECO:0000269|PubMed:23209413, ECO:0000269|PubMed:24600035, ECO:0000269|PubMed:25808313, ECO:0000269|PubMed:29531227, ECO:0000269|PubMed:7743181, ECO:0000269|PubMed:9620674}.; FUNCTION: Allele B*07:02: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and mainly a Leu anchor residue at the C-terminus (PubMed:7743181). Presents a long peptide (APRGPHGGAASGL) derived from the cancer-testis antigen CTAG1A/NY-ESO-1, eliciting a polyclonal CD8-positive T cell response against tumor cells (PubMed:29531227). Presents viral epitopes derived from HIV-1 gag-pol (TPQDLNTML) and Nef (RPQVPLRPM) (PubMed:25808313). Presents an immunodominant epitope derived from SARS-CoV-2 N/nucleoprotein (SPRWYFYYL) (PubMed:32887977). Displays self-peptides including a peptide derived from the signal sequence of HLA-DPB1 (APRTVALTA) (PubMed:7743181). {ECO:0000269|PubMed:25808313, ECO:0000269|PubMed:29531227, ECO:0000269|PubMed:32887977, ECO:0000269|PubMed:7743181}.; FUNCTION: Allele B*08:01: Presents to CD8-positive T cells viral epitopes derived from EBV/HHV-4 EBNA3 (QAKWRLQTL), eliciting cytotoxic T cell response. {ECO:0000269|PubMed:9620674}.; FUNCTION: Allele B*13:02: Presents multiple HIV-1 epitopes derived from gag (RQANFLGKI, GQMREPRGSDI), nef (RQDILDLWI), gag-pol (RQYDQILIE, GQGQWTYQI) and rev (LQLPPLERL), all having in common a Gln residue at position 2 and mainly hydrophobic amino acids Leu, Ile or Val at the C-terminus. Associated with successful control of HIV-1 infection. {ECO:0000269|PubMed:17251285}.; FUNCTION: Allele B*18:01: Preferentially presents octameric and nonameric peptides sharing a common motif, namely a Glu at position 2 and Phe or Tyr anchor residues at the C-terminus (PubMed:14978097, PubMed:18991276, PubMed:23749632). Presents an EBV/HHV-4 epitope derived from BZLF1 (SELEIKRY) (PubMed:23749632). May present to CD8-positive T cells an antigenic peptide derived from MAGEA3 (MEVDPIGHLY), triggering an anti-tumor immune response (PubMed:12366779). May display a broad repertoire of self-peptides with a preference for peptides derived from RNA-binding proteins (PubMed:14978097). {ECO:0000269|PubMed:12366779, ECO:0000269|PubMed:14978097, ECO:0000269|PubMed:18991276, ECO:0000269|PubMed:23749632}.; FUNCTION: Allele B*27:05: Presents to CD8-positive T cells immunodominant viral epitopes derived from HCV POLG (ARMILMTHF), HIV-1 gag (KRWIILGLNK), IAV NP (SRYWAIRTR), SARS-CoV-2 N/nucleoprotein (QRNAPRITF), EBV/HHV-4 EBNA4 (HRCQAIRKK) and EBV/HHV-4 EBNA6 (RRIYDLIEL), conferring longterm protection against viral infection (PubMed:15113903, PubMed:18385228, PubMed:19139562, PubMed:32887977, PubMed:9620674). Can present self-peptides derived from cytosolic and nuclear proteins. All peptides carry an Arg at position 2 (PubMed:1922338). The peptide-bound form interacts with NK cell inhibitory receptor KIR3DL1 and inhibits NK cell activation in a peptide-specific way, being particularly sensitive to the nature of the amino acid side chain at position 8 of the antigenic peptide (PubMed:15657948, PubMed:8879234). KIR3DL1 fails to recognize HLA-B*27:05 in complex with B2M and EBV/HHV-4 EBNA6 (RRIYDLIEL) peptide, which can lead to increased activation of NK cells during infection (PubMed:15657948). May present an altered repertoire of peptides in the absence of TAP1-TAP2 and TAPBPL (PubMed:9620674). {ECO:0000269|PubMed:15113903, ECO:0000269|PubMed:15657948, ECO:0000269|PubMed:18385228, ECO:0000269|PubMed:19139562, ECO:0000269|PubMed:1922338, ECO:0000269|PubMed:8879234, ECO:0000269|PubMed:9620674}.; FUNCTION: Allele B*40:01: Presents immunodominant viral epitopes derived from EBV/HHV-4 LMP2 (IEDPPFNSL) and SARS-CoV-2 N/nucleoprotein (MEVTPSGTWL), triggering memory CD8-positive T cell response (PubMed:18991276, PubMed:32887977). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and a Leu anchor residue at the C-terminus (PubMed:18991276). {ECO:0000269|PubMed:18991276, ECO:0000269|PubMed:32887977}.; FUNCTION: Allele B*41:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus. {ECO:0000269|PubMed:18991276}.; FUNCTION: Allele B*44:02: Presents immunodominant viral epitopes derived from EBV/HHV-4 EBNA4 (VEITPYKPTW) and EBNA6 (AEGGVGWRHW, EENLLDFVRF), triggering memory CD8-positive T cell response (PubMed:18991276, PubMed:9620674). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Phe, Tyr or Trp anchor residues at the C-terminus (PubMed:18991276). {ECO:0000269|PubMed:18991276, ECO:0000269|PubMed:9620674}.; FUNCTION: Allele B*45:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus. {ECO:0000269|PubMed:18991276}.; FUNCTION: Allele B*46:01: Preferentially presents nonameric peptides sharing a signature motif, namely Ala and Leu at position 2 and Tyr, Phe, Leu, or Met anchor residues at the C-terminus. The peptide-bound form interacts with KIR2DL3 and inhibits NK cell cytotoxic response in a peptide-specific way. {ECO:0000269|PubMed:28514659}.; FUNCTION: Allele B*47:01: Displays self-peptides sharing a signature motif, namely an Asp at position 2 and Leu or Met anchor residues at the C-terminus. {ECO:0000269|PubMed:18991276}.; FUNCTION: Allele B*49:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ile or Val anchor residues at the C-terminus. {ECO:0000269|PubMed:18991276}.; FUNCTION: Allele B*50:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus. {ECO:0000269|PubMed:18991276}.; FUNCTION: Allele B*51:01: Presents an octameric HIV-1 epitope derived from gag-pol (TAFTIPSI) to the public TRAV17/TRBV7-3 TCR clonotype, strongly suppressing HIV-1 replication. {ECO:0000269|PubMed:24600035}.; FUNCTION: Allele B*54:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus. {ECO:0000269|PubMed:7743181}.; FUNCTION: Allele B*55:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus. {ECO:0000269|PubMed:7743181}.; FUNCTION: Allele B*56:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus. {ECO:0000269|PubMed:7743181}.; FUNCTION: Allele B*57:01: The peptide-bound form recognizes KIR3DL1 and inhibits NK cell cytotoxic response. Presents HIV gag peptides (immunodominant KAFSPEVIPMF and subdominant KALGPAATL epitopes) predominantly to CD8-positive T cell clones expressing a TRAV41-containing TCR, triggering HLA-B-restricted T cell responses. {ECO:0000269|PubMed:22020283, ECO:0000269|PubMed:25480565, ECO:0000269|PubMed:34228645}.; FUNCTION: Allele B*67:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Leu anchor residue at the C-terminus. {ECO:0000269|PubMed:7743181}.
uniprot
proteins
mass_dalton
40460
uniprot
proteins
pubmed
10395103
uniprot
proteins
pubmed
11390610
uniprot
proteins
pubmed
11888582
uniprot
proteins
pubmed
12366779
uniprot
proteins
pubmed
12622774
uniprot
proteins
pubmed
1317015
uniprot
proteins
pubmed
1362296
uniprot
proteins
pubmed
1385528
uniprot
proteins
pubmed
1431115
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1481202
uniprot
proteins
pubmed
14978097
uniprot
proteins
pubmed
15057820
uniprot
proteins
pubmed
15113903
uniprot
proteins
pubmed
15489334
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proteins
pubmed
15603872
uniprot
proteins
pubmed
15657948
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proteins
pubmed
1691230
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proteins
pubmed
1699887
uniprot
proteins
pubmed
17057332
uniprot
proteins
pubmed
17251285
uniprot
proteins
pubmed
1737933
uniprot
proteins
pubmed
18385228
uniprot
proteins
pubmed
18991276
uniprot
proteins
pubmed
19139562
uniprot
proteins
pubmed
19159218
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proteins
pubmed
1922338
uniprot
proteins
pubmed
20356336
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proteins
pubmed
21269460
uniprot
proteins
pubmed
21585707
uniprot
proteins
pubmed
21868630
uniprot
proteins
pubmed
22020283
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proteins
pubmed
22286218
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proteins
pubmed
2251138
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proteins
pubmed
2320591
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proteins
pubmed
23209413
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proteins
pubmed
23291587
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proteins
pubmed
23749632
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proteins
pubmed
2437025
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proteins
pubmed
24600035
uniprot
proteins
pubmed
25480565
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proteins
pubmed
25808313
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proteins
pubmed
25944712
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proteins
pubmed
26416272
uniprot
proteins
pubmed
26439010
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proteins
pubmed
2714852
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proteins
pubmed
2715640
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proteins
pubmed
2788131
uniprot
proteins
pubmed
28514659
uniprot
proteins
pubmed
28650991
uniprot
proteins
pubmed
29531227
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proteins
pubmed
2995352
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proteins
pubmed
3011411
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proteins
pubmed
3257938
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proteins
pubmed
32887977
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proteins
pubmed
34228645
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proteins
pubmed
3489755
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proteins
pubmed
37264229
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proteins
pubmed
518865
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proteins
pubmed
7517584
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proteins
pubmed
7517915
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proteins
pubmed
7521976
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proteins
pubmed
7524186
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proteins
pubmed
7558929
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proteins
pubmed
7725307
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proteins
pubmed
7743181
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proteins
pubmed
8362411
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proteins
pubmed
8420828
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proteins
pubmed
8423049
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proteins
pubmed
8547229
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proteins
pubmed
8740766
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proteins
pubmed
8773315
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proteins
pubmed
8847228
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proteins
pubmed
8851728
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proteins
pubmed
8879234
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proteins
pubmed
9036970
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proteins
pubmed
9620674
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25480565, ECO:0000269|PubMed:26439010, ECO:0000269|PubMed:9620674}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:9620674}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 310..333; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins