Stat5a
entrez
24918
canonical
uniprot
Q62771
canonical
ensembl
ENSRNOG00000019496
resolver
ensp
ENSRNOP00000026662
resolver
enst
ENSRNOT00000026662
resolver
genesymbol
Stat5a
resolver
genesymbol_syn
Mgf
resolver
uniprot
G3V8K7
resolver
uniprot_entry
G3V8K7_RAT
resolver
uniprot_entry
STA5A_RAT
resolver
amino_acid_sequence
MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRGQATQLLEGLVQELQKKAEHQVGEDGFVLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNCSSPAGVLVDAMSQKHLQINQTFEELRLITQDTESELKKLQQTQEYFIIQYQESLRIQAQFGQLAQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELVEKHQKTLQLLRKQQTIILDDELIQWKRGQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNRRSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVFAKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGANATYMDQAPSPVVCPQAHYNMYPPNPDPVLDQDGEFDLDETMDVARHVEELLRRPMDSLDPRLSPPAGLFTSARSSLS
uniprot
proteins
function
FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. {ECO:0000269|PubMed:19088846}.
uniprot
proteins
mass_dalton
90833
uniprot
proteins
post_translational_modification
PTM: ISGylated. {ECO:0000250|UniProtKB:P42230}.; PTM: Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO (By similarity). Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus (By similarity). Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:22673903). Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 at Tyr-694 (By similarity). {ECO:0000250|UniProtKB:P40763, ECO:0000250|UniProtKB:P42229, ECO:0000250|UniProtKB:P42230}.
uniprot
proteins
protein_family
Transcription factor STAT family
uniprot
proteins
pubmed
19088846
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8584036
uniprot
proteins
sequence_length
793
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mostly cytoplasmic during pregnancy, whereas it becomes predominantly nuclear during early lactation. It is translocated into the nucleus in response to phosphorylation (By similarity). {ECO:0000250}.
uniprot
proteins