Acss1
entrez
68738
canonical
uniprot
Q99NB1
canonical
ensembl
ENSMUSG00000027452
resolver
ensp
ENSMUSP00000028944
resolver
enst
ENSMUST00000028944
resolver
genesymbol
Acss1
resolver
genesymbol_syn
Acas2
resolver
genesymbol_syn
Acas2l
resolver
genesymbol_syn
mKIAA1846
resolver
uniprot
Q3UJ89
resolver
uniprot
Q69Z91
resolver
uniprot
Q8K0M6
resolver
uniprot_entry
ACS2L_MOUSE
resolver
uniprot_entry
Q3UJ89_MOUSE
resolver
uniprot_entry
Q69Z91_MOUSE
resolver
uniprot_sec
Q8K0M6
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by acetylation at Lys-635 and activated by deacetylation mediated by the deacetylase SIRT3. {ECO:0000269|PubMed:16790548}.
uniprot
proteins
amino_acid_sequence
MAARSLGSGVGRLLRGLQGRSGQSGWSLSVSRSTATRLPGCVPAAAQPGSYPALSAQAAQEPAAFWGPLARDTLVWDTPYHTVWDCDFRTGKIGWFLGGQLNVSVNCLDQHVQKSPETIALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAIHTVVFAGFSAESLAGRINDAKCKAVITFNQGLRGGRVVELKKIVDEAVKSCPTVQHVLVAHRTDTKVPMGSLDIPLEQEMAKEAPVCTPESMSSEDMLFMLYTSGSTGTPKGLVHTQAGYLLYAAMTHKLVFDYQPGDVFGCVADIGWITGHSYVVYGPLCNGATTVLFESTPVYPDAGRYWETVQRLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINHEAWEWLHKVVGDGRCTLVDTWWQTETGGICIAPRPSEDGAEILPGMAMRPFFGIVPVLMDEKGNVLEGGDVSGALCISQAWPGMARTIYGDHQRFVDAYFRAYPGYYFTGDGAHRTEGGYYQITGRMDDVINISGHRLGTAEIEDAMADHPAVPETAVIGYPHDIKGEAAFAFIVLKDNISDENMVVNELKLSVATKIAKYAVPDQILVVKRLPKTRSGKVMRRLLRKIITSRGQDLGDTTTLEDPSVITEILSAFQKYEEQRAATN
uniprot
proteins
ec_number
6.2.1.1
uniprot
proteins
ec_number
6.2.1.17
uniprot
proteins
function
FUNCTION: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:11150295, PubMed:16790548). Acetate is the preferred substrate (PubMed:11150295, PubMed:16790548). Can also utilize propionate with a much lower affinity (PubMed:11150295). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (PubMed:11150295). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (PubMed:19187775). {ECO:0000269|PubMed:11150295, ECO:0000269|PubMed:16790548, ECO:0000269|PubMed:19187775}.
uniprot
proteins
mass_dalton
74623
uniprot
proteins
post_translational_modification
PTM: Reversibly acetylated at Lys-635 (PubMed:16790548). The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation mediated by the deacetylase SIRT3. {ECO:0000269|PubMed:16790548}.
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
11150295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16790548
uniprot
proteins
pubmed
19187775
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
682
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:11150295}.
uniprot
proteins