CNOT4
entrez
4850
canonical
uniprot
O95628
canonical
ensembl
ENSG00000080802
resolver
ensp
ENSP00000326731
resolver
ensp
ENSP00000354673
resolver
ensp
ENSP00000388491
resolver
ensp
ENSP00000399108
resolver
ensp
ENSP00000406777
resolver
ensp
ENSP00000445508
resolver
ensp
ENSP00000516715
resolver
genesymbol
CNOT4
resolver
genesymbol_syn
NOT4
resolver
hgnc
HGNC:7880
resolver
uniprot
B7Z6I4
resolver
uniprot
E7ET38
resolver
uniprot
F8VQP3
resolver
uniprot
O95339
resolver
uniprot
O95627
resolver
uniprot
Q8IYM7
resolver
uniprot
Q8NCL0
resolver
uniprot
Q9NPQ1
resolver
uniprot
Q9NZN6
resolver
uniprot_entry
CNOT4_HUMAN
resolver
uniprot_sec
B7Z6I4
resolver
uniprot_sec
E7ET38
resolver
uniprot_sec
F8VQP3
resolver
uniprot_sec
O95339
resolver
uniprot_sec
O95627
resolver
uniprot_sec
Q8IYM7
resolver
uniprot_sec
Q8NCL0
resolver
uniprot_sec
Q9NPQ1
resolver
uniprot_sec
Q9NZN6
resolver
amino_acid_sequence
MSRSPDAKEDPVECPLCMEPLEIDDINFFPCTCGYQICRFCWHRIRTDENGLCPACRKPYPEDPAVYKPLSQEELQRIKNEKKQKQNERKQKISENRKHLASVRVVQKNLVFVVGLSQRLADPEVLKRPEYFGKFGKIHKVVINNSTSYAGSQGPSASAYVTYIRSEDALRAIQCVNNVVVDGRTLKASLGTTKYCSYFLKNMQCPKPDCMYLHELGDEAASFTKEEMQAGKHQEYEQKLLQELYKLNPNFLQLSTGSVDKNKNKVTPLQRYDTPIDKPSDSLSIGNGDNSQQISNSDTPSPPPGLSKSNPVIPISSSNHSARSPFEGAVTESQSLFSDNFRHPNPIPSGLPPFPSSPQTSSDWPTAPEPQSLFTSETIPVSSSTDWQAAFGFGSSKQPEDDLGFDPFDVTRKALADLIEKELSVQDQPSLSPTSLQNSSSHTTTAKGPGSGFLHPAAATNANSLNSTFSVLPQRFPQFQQHRAVYNSFSFPGQAARYPWMAFPRNSIMHLNHTANPTSNSNFLDLNLPPQHNTGLGGIPVAGEEEVKVSTMPLSTSSHSLQQGQQPTSLHTTVA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292). Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038). Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292). Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391). {ECO:0000269|PubMed:11823428, ECO:0000269|PubMed:22159038, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:29861391}.
uniprot
proteins
mass_dalton
63510
uniprot
proteins
mutagenesis
MUTAGEN 16; /note="L->A,E: Abolishes interaction with E2 ubiquitin ligases."; /evidence="ECO:0000269|PubMed:11823428"; MUTAGEN 17; /note="C->A: Abolishes interaction with E2 ubiquitin ligases."; /evidence="ECO:0000269|PubMed:11823428"; MUTAGEN 18; /note="M->A: Strongly reduces interaction with E2 ubiquitin ligases."; /evidence="ECO:0000269|PubMed:11823428"; MUTAGEN 33; /note="C->R: Abolishes interaction with E2 ubiquitin ligases."; /evidence="ECO:0000269|PubMed:11823428"; MUTAGEN 42; /note="W->A: Strongly reduces interaction with E2 ubiquitin ligases."; /evidence="ECO:0000269|PubMed:11823428"; MUTAGEN 44; /note="R->A,E: Strongly reduces interaction with E2 ubiquitin ligases."; /evidence="ECO:0000269|PubMed:11823428"; MUTAGEN 45; /note="I->A,W: Strongly reduces interaction with E2 ubiquitin ligases."; /evidence="ECO:0000269|PubMed:11823428"; MUTAGEN 49; /note="E->A: Strongly reduces interaction with E2 ubiquitin ligases."; /evidence="ECO:0000269|PubMed:11823428, ECO:0000269|PubMed:15001359"; MUTAGEN 49; /note="E->K: Strongly reduced interaction with UBE2D2."; /evidence="ECO:0000269|PubMed:11823428, ECO:0000269|PubMed:15001359"; MUTAGEN 54; /note="P->A: Strongly reduces interaction with E2 ubiquitin ligases."; /evidence="ECO:0000269|PubMed:11823428"; MUTAGEN 57; /note="R->A,E: Strongly reduces interaction with E2 ubiquitin ligases."; /evidence="ECO:0000269|PubMed:11823428
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:26575292}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000269|PubMed:11823428, ECO:0000269|PubMed:15001359}.
uniprot
proteins
pubmed
10637334
uniprot
proteins
pubmed
11087754
uniprot
proteins
pubmed
11823428
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15001359
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22159038
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
26575292
uniprot
proteins
pubmed
29861391
uniprot
proteins
sequence_length
575
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
uniprot
proteins