Bco1
entrez
63857
canonical
uniprot
Q9JJS6
canonical
ensembl
ENSMUSG00000031845
resolver
ensp
ENSMUSP00000034308
resolver
ensp
ENSMUSP00000134815
resolver
enst
ENSMUST00000034308
resolver
enst
ENSMUST00000176860
resolver
genesymbol
Bco1
resolver
genesymbol_syn
Bcdo
resolver
genesymbol_syn
Bcdo1
resolver
genesymbol_syn
Bcmo1
resolver
uniprot
E9Q321
resolver
uniprot
Q05AC0
resolver
uniprot
Q6K1L5
resolver
uniprot
Q8C6N5
resolver
uniprot
Q9ERN9
resolver
uniprot_entry
BCDO1_MOUSE
resolver
uniprot_entry
E9Q321_MOUSE
resolver
uniprot_entry
Q05AC0_MOUSE
resolver
uniprot_sec
Q6K1L5
resolver
uniprot_sec
Q8C6N5
resolver
uniprot_sec
Q9ERN9
resolver
amino_acid_sequence
MEIIFGQNKKEQLEPVQAKVTGSIPAWLQGTLLRNGPGMHTVGESKYNHWFDGLALLHSFSIRDGEVFYRSKYLQSDTYIANIEANRIVVSEFGTMAYPDPCKNIFSKAFSYLSHTIPDFTDNCLINIMKCGEDFYATTETNYIRKIDPQTLETLEKVDYRKYVAVNLATSHPHYDEAGNVLNMGTSVVDKGRTKYVIFKIPATVPDSKKKGKSPVKHAEVFCSISSRSLLSPSYYHSFGVTENYVVFLEQPFKLDILKMATAYMRGVSWASCMSFDREDKTYIHIIDQRTRKPVPTKFYTDPMVVFHHVNAYEEDGCVLFDVIAYEDSSLYQLFYLANLNKDFEEKSRLTSVPTLRRFAVPLHVDKDAEVGSNLVKVSSTTATALKEKDGHVYCQPEVLYEGLELPRINYAYNGKPYRYIFAAEVQWSPVPTKILKYDILTKSSLKWSEESCWPAEPLFVPTPGAKDEDDGVILSAIVSTDPQKLPFLLILDAKSFTELARASVDADMHLDLHGLFIPDADWNAVKQTPAETQEVENSDHPTDPTAPELSHSENDFTAGHGGSSL
uniprot
proteins
ec_number
1.13.11.63
uniprot
proteins
function
FUNCTION: Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism. {ECO:0000269|PubMed:11092891, ECO:0000269|PubMed:15951442}.
uniprot
proteins
mass_dalton
63864
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="H->A: No significant effect on beta-carotene 15,15'-monooxygenase activity. Decreased stability."; /evidence="ECO:0000269|PubMed:15951442"; MUTAGEN 52; /note="D->A: Decreased beta-carotene 15,15'-monooxygenase activity. Decreased catalytic efficiency. Loss of beta-carotene 15,15'-monooxygenase activity; when associated with A-140."; /evidence="ECO:0000269|PubMed:15951442"; MUTAGEN 58; /note="H->A: No significant effect on beta-carotene 15,15'-monooxygenase activity. Decreased catalytic efficiency."; /evidence="ECO:0000269|PubMed:15951442"; MUTAGEN 140; /note="E->A: Decreased beta-carotene 15,15'-monooxygenase activity. Decreased catalytic efficiency. Loss of beta-carotene 15,15'-monooxygenase activity; when associated with A-52."; /evidence="ECO:0000269|PubMed:15951442"; MUTAGEN 172; /note="H->A: No effect on protein abundance. Loss of beta-carotene 15,15'-monooxygenase activity. Decreased iron binding."; /evidence="ECO:0000269|PubMed:15951442"; MUTAGEN 174; /note="H->A: No significant effect on beta-carotene 15,15'-monooxygenase activity."; /evidence="ECO:0000269|PubMed:15951442"; MUTAGEN 237; /note="H->A: No effect on protein abundance. Loss of beta-carotene 15,15'-monooxygenase activity. Decreased iron binding."; /evidence="ECO:0000269|PubMed:15951442"; MUTAGEN 308; /note="H->A: No effect on protein abundance. Loss of beta-carotene 15,15'-monooxygenase activity. Decreased iron binding."; /evidence="ECO:0000269|PubMed:15951442"; MUTAGEN 309; /note="H->A: No significant effect on beta-carotene 15,15'-monooxygenase activity."; /evidence="ECO:0000269|PubMed:15951442"; MUTAGEN 314; /note="E->A: No significant effect on beta-carotene 15,15'-monooxygenase activity."; /evidence="ECO:0000269|PubMed:15951442"; MUTAGEN 405; /note="E->A: Loss of beta-carotene 15,15'-monooxygenase activity."; /evidence="ECO:0000269|PubMed:15951442"; MUTAGEN 450; /note="E->A: No significant effect on beta-carotene 15,15'-monooxygenase activity."; /evidence="ECO:0000269|PubMed:15951442"; MUTAGEN 457; /note="E->A: Decreased beta-carotene 15,15'-monooxygenase activity."; /evidence="ECO:0000269|PubMed:15951442"; MUTAGEN 469; /note="E->A: Decreased beta-carotene 15,15'-monooxygenase activity."; /evidence="ECO:0000269|PubMed:15951442"; MUTAGEN 514; /note="H->A: No effect on protein abundance. Loss of beta-carotene 15,15'-monooxygenase activity. Loss of iron binding."; /evidence="ECO:0000269|PubMed:15951442
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000305|PubMed:11092891}.
uniprot
proteins
protein_family
Carotenoid oxygenase family
uniprot
proteins
pubmed
11092891
uniprot
proteins
pubmed
11237856
uniprot
proteins
pubmed
11401432
uniprot
proteins
pubmed
12759335
uniprot
proteins
pubmed
15951442
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
566
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9I993}.
uniprot
proteins