Krt14
entrez
287701
canonical
uniprot
Q6IFV1
canonical
ensembl
ENSRNOG00055033529
resolver
ensembl
ENSRNOG00060032139
resolver
ensembl
ENSRNOG00065033359
resolver
ensp
ENSRNOP00055047791
resolver
ensp
ENSRNOP00060046035
resolver
ensp
ENSRNOP00065047188
resolver
enst
ENSRNOT00055057951
resolver
enst
ENSRNOT00060055672
resolver
enst
ENSRNOT00065057347
resolver
genesymbol
Krt14
resolver
genesymbol_syn
Ka14
resolver
genesymbol_syn
Krt1-14
resolver
uniprot
O35813
resolver
uniprot_entry
K1C14_RAT
resolver
uniprot_sec
O35813
resolver
amino_acid_sequence
MATCSRQFTSSSSMKGSCGIGGGSSRMSSVLAGGSCRAPSTYGGMSRFSSAGAYAVGSGYGGGFSSSSFGGGFGGGIGGGIGGGLGGGIGGGFGGGIGGGFGGGIGSGFGGGLGDGLLVGSEKVTMQNLNDRLATYLDKVRALEEANSDLEVKIRDWYQRQRPTEIKDYSPYFKTIEDLKSKILAATVDNANVLLQIDNARLAADDFRTKFETEQSLRINVESDINGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMASMRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFTKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENNLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSAQFSSSSQFSSGSQSSRDVTSTNRQIRTKVMDVHDGKVVSTHEQVLRTKN
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in basal keratinocytes of stratified epithelia. Forms heteropolymers with type II keratin KRT5, contributing to the keratin intermediate filament network that confers mechanical strength and structural integrity to the basal layer of the epidermis and other stratified epithelial. The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. Displays an antagonist role with KRT15 in basal epithelial cells, where KRT14 promotes cell differentiation while KRT15 maintains the progenitor state and promotes proliferation and clonogenicity. Promotes cell differentiation by retaining YAP1 in the cytoplasm of basal keratinocytes via regulatory residue C374 and stratifin/SNF interaction. Contributes to airway basal cell differentiation after injury. {ECO:0000250|UniProtKB:P02533}.
uniprot
proteins
mass_dalton
52684
uniprot
proteins
post_translational_modification
PTM: A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus. {ECO:0000250|UniProtKB:Q61781}.; PTM: Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex. {ECO:0000250|UniProtKB:P02533}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15085952
uniprot
proteins
pubmed
8950218
uniprot
proteins
sequence_length
485
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P02533}. Nucleus {ECO:0000250|UniProtKB:P02533}. Note=Expressed in both as a filamentous pattern. {ECO:0000250|UniProtKB:P02533}.
uniprot
proteins