Spdya
entrez
70891
canonical
uniprot
Q5IBH7
canonical
ensembl
ENSMUSG00000052525
resolver
ensp
ENSMUSP00000118426
resolver
ensp
ENSMUSP00000118994
resolver
ensp
ENSMUSP00000125912
resolver
genesymbol
Spdya
resolver
genesymbol_syn
Spdy1
resolver
uniprot
B2RWC8
resolver
uniprot
B8JJC0
resolver
uniprot
Q5IBH8
resolver
uniprot
Q8C5T5
resolver
uniprot_entry
B2RWC8_MOUSE
resolver
uniprot_entry
SPDYA_MOUSE
resolver
uniprot_sec
B8JJC0
resolver
uniprot_sec
Q5IBH8
resolver
uniprot_sec
Q8C5T5
resolver
amino_acid_sequence
MRHNQMYCETPPTVTIHVKSGSNRSHQTRKPISLKRPILKDSWEASENNAQNNKSKRPRGPCLIIQRQEMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTINEHTRINFFIALYLANTVEEDEEEAKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRDEVHLPRGPSATPVDCSLCGKKGRYVRLGLSSSSSSSSDTGELMEKDSQELHSAFSVDTAGDPPHTYSQVANDHQSNKENETNFVKKNKSVEWFAESEE
uniprot
proteins
function
FUNCTION: Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:15611625). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation. Interferes with CDKN1B-mediated inhibition of CDK2. Mediates cell survival during the DNA damage process through activation of CDK2 (By similarity). {ECO:0000250|UniProtKB:Q5MJ70, ECO:0000269|PubMed:15611625}.
uniprot
proteins
mass_dalton
36115
uniprot
proteins
mutagenesis
MUTAGEN 89; /note="D->A: Abolishes interaction with CDK2."; /evidence="ECO:0000269|PubMed:15611625"; MUTAGEN 102; /note="M->A: Abolishes interaction with CDK2."; /evidence="ECO:0000269|PubMed:15611625"; MUTAGEN 106; /note="Y->A: Abolishes interaction with CDK2."; /evidence="ECO:0000269|PubMed:15611625"; MUTAGEN 107; /note="F->A: Abolishes interaction with CDK2."; /evidence="ECO:0000269|PubMed:15611625"; MUTAGEN 133..135; /note="EED->AAA: No effect on CDK2-binding."; /evidence="ECO:0000269|PubMed:15611625
uniprot
proteins
protein_family
Speedy/Ringo family
uniprot
proteins
pubmed
11730327
uniprot
proteins
pubmed
15611625
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20339383
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20339383}.
uniprot
proteins