Kcnma1
entrez
16531
canonical
uniprot
Q08460
canonical
ensembl
ENSMUSG00000063142
resolver
ensp
ENSMUSP00000140033
resolver
ensp
ENSMUSP00000140275
resolver
ensp
ENSMUSP00000140751
resolver
ensp
ENSMUSP00000141069
resolver
ensp
ENSMUSP00000152959
resolver
ensp
ENSMUSP00000152999
resolver
ensp
ENSMUSP00000153078
resolver
ensp
ENSMUSP00000153083
resolver
ensp
ENSMUSP00000153158
resolver
ensp
ENSMUSP00000153214
resolver
ensp
ENSMUSP00000153216
resolver
ensp
ENSMUSP00000153247
resolver
ensp
ENSMUSP00000153291
resolver
ensp
ENSMUSP00000153312
resolver
ensp
ENSMUSP00000153316
resolver
ensp
ENSMUSP00000153362
resolver
ensp
ENSMUSP00000153527
resolver
ensp
ENSMUSP00000153584
resolver
ensp
ENSMUSP00000153670
resolver
enst
ENSMUST00000145596
resolver
enst
ENSMUST00000188285
resolver
enst
ENSMUST00000188991
resolver
enst
ENSMUST00000190044
resolver
enst
ENSMUST00000224468
resolver
genesymbol
Kcnma1
resolver
genesymbol_syn
Kcnma
resolver
uniprot
A0A087WQ41
resolver
uniprot
A0A087WQN5
resolver
uniprot
A0A087WRS4
resolver
uniprot
A0A286YD35
resolver
uniprot
A0A286YDM6
resolver
uniprot
Q3UXG3
resolver
uniprot
Q64703
resolver
uniprot
Q8VHF1
resolver
uniprot
Q9R196
resolver
uniprot_entry
A0A087WQ41_MOUSE
resolver
uniprot_entry
A0A087WQN5_MOUSE
resolver
uniprot_entry
A0A087WRS4_MOUSE
resolver
uniprot_entry
A0A286YD35_MOUSE
resolver
uniprot_entry
A0A286YDM6_MOUSE
resolver
uniprot_entry
KCMA1_MOUSE
resolver
uniprot_entry
Q3UXG3_MOUSE
resolver
uniprot_sec
Q64703
resolver
uniprot_sec
Q8VHF1
resolver
uniprot_sec
Q9R196
resolver
activity_regulation
ACTIVITY REGULATION: Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation (By similarity). {ECO:0000250|UniProtKB:Q12791}.
uniprot
proteins
amino_acid_sequence
MANGGGGGGGSSGGGGGGGGGSGLRMSSNIHANNLSLDASSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEVVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRSRKRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDVTDPKRIKKCGCRRLEDEQPPTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELAKPGKLPLVSVNQEKNSGTHILMITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRPNRPKSRESRDKQNRKEMVYR
uniprot
proteins
function
FUNCTION: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). {ECO:0000250|UniProtKB:Q12791}.; FUNCTION: [Isoform 2]: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). {ECO:0000269|PubMed:7687074}.; FUNCTION: [Isoform 3]: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). {ECO:0000269|PubMed:12388098}.; FUNCTION: [Isoform 4]: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). {ECO:0000269|PubMed:10517674}.
uniprot
proteins
mass_dalton
134396
uniprot
proteins
mutagenesis
MUTAGEN 151; /note="V->T: Loss of phosphorylation-independent activation of channel activity by ethanol. CaMK2-dependent phosphorylation leads to populations of partially phosphorylated tetramers with a range of responses to ethanol from activation to inhibition."; /evidence="ECO:0000269|PubMed:16341213"; MUTAGEN 272; /note="R->Q: Alters the voltage-dependent gating."; /evidence="ECO:0000269|PubMed:11112549"; MUTAGEN 278; /note="R->Q: Alters the voltage-dependent gating."; /evidence="ECO:0000269|PubMed:11112549"; MUTAGEN 284; /note="E->R: Alters the voltage-dependent gating; when associated with R-287."; /evidence="ECO:0000269|PubMed:11112549"; MUTAGEN 287; /note="Q->R: Alters the voltage-dependent gating; when associated with K-284."; /evidence="ECO:0000269|PubMed:11112549"; MUTAGEN 427; /note="D->A: Does not affect sensitivity to Ca(2+)."; /evidence="ECO:0000269|PubMed:12192411"; MUTAGEN 432; /note="D->A: Reduced sensitivity to Ca(2+)."; /evidence="ECO:0000269|PubMed:12192411"; MUTAGEN 434; /note="D->A: Does not affect sensitivity to Ca(2+)."; /evidence="ECO:0000269|PubMed:12192411"; MUTAGEN 439; /note="E->A: Abolishes sensitivity to Mg(2+), but not sensitivity to Ca(2+)."; /evidence="ECO:0000269|PubMed:12192410"; MUTAGEN 444; /note="H->G: Reduces sensitivity to Mg(2+), but not sensitivity to Ca(2+)."; /evidence="ECO:0000269|PubMed:12192410"; MUTAGEN 461; /note="T->A: Reduces sensitivity to Mg(2+), but not sensitivity to Ca(2+)."; /evidence="ECO:0000269|PubMed:12192410"; MUTAGEN 462; /note="Q->C: Reduces sensitivity to Mg(2+), but not sensitivity to Ca(2+)."; /evidence="ECO:0000269|PubMed:12192410"; MUTAGEN 464; /note="E->D,A: Remains sensitive to Mg(2+)."; /evidence="ECO:0000269|PubMed:12192410, ECO:0000269|PubMed:12192411"; MUTAGEN 464; /note="E->N: Abolishes sensitivity to Mg(2+), but not sensitivity to Ca(2+)."; /evidence="ECO:0000269|PubMed:12192410, ECO:0000269|PubMed:12192411"; MUTAGEN 992..996; /note="DDDPD->AAAAA: Alters calcium binding."; /evidence="ECO:0000269|PubMed:12149279
uniprot
proteins
post_translational_modification
PTM: Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity. {ECO:0000305}.; PTM: Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network (By similarity). {ECO:0000250|UniProtKB:Q12791}.
uniprot
proteins
protein_family
Calcium-activated (TC 1.A.1.3) subfamily
uniprot
proteins
protein_family
KCa1.1/KCNMA1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10517674
uniprot
proteins
pubmed
10804197
uniprot
proteins
pubmed
11112549
uniprot
proteins
pubmed
12149279
uniprot
proteins
pubmed
12192410
uniprot
proteins
pubmed
12192411
uniprot
proteins
pubmed
12388098
uniprot
proteins
pubmed
16341213
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22935415
uniprot
proteins
pubmed
7687074
uniprot
proteins
pubmed
7987297
uniprot
proteins
sequence_length
1209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q12791}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 87..107; /note="Helical; Name=Segment S0"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 215..235; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 240..260; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 301..321; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 368..388; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins