SLC30A5
entrez
64924
canonical
uniprot
Q8TAD4
canonical
ensembl
ENSG00000145740
resolver
ensp
ENSP00000370241
resolver
ensp
ENSP00000379836
resolver
ensp
ENSP00000421251
resolver
ensp
ENSP00000793339
resolver
genesymbol
SLC30A5
resolver
genesymbol_syn
ZNT5
resolver
genesymbol_syn
ZNTL1
resolver
genesymbol_syn
ZTL1
resolver
hgnc
HGNC:19089
resolver
uniprot
B7ZM89
resolver
uniprot
Q6UX54
resolver
uniprot
Q7L4M4
resolver
uniprot
Q8TDG3
resolver
uniprot
Q9BVY8
resolver
uniprot
Q9H9H1
resolver
uniprot_entry
ZNT5_HUMAN
resolver
uniprot_sec
B7ZM89
resolver
uniprot_sec
Q6UX54
resolver
uniprot_sec
Q7L4M4
resolver
uniprot_sec
Q8TDG3
resolver
uniprot_sec
Q9BVY8
resolver
uniprot_sec
Q9H9H1
resolver
amino_acid_sequence
MEEKYGGDVLAGPGGGGGLGPVDVPSARLTKYIVLLCFTKFLKAVGLFESYDLLKAVHIVQFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLRTLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPEGHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQALSHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSKCARYGSFPIFISALLFGNFWTHPITDQLRAMNKAAHQESTEHVLSGGVVVSAIFFILSANILSSPSKRGQKGTLIGYSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIFYFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYGYGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAFSHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQVTGILKDAGVNNLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM
uniprot
proteins
function
FUNCTION: Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:11904301, PubMed:15525635, PubMed:15994300, PubMed:19366695, PubMed:22529353). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15525635, PubMed:15994300, PubMed:16636052, PubMed:35525268). Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin (PubMed:11904301). {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:15525635, ECO:0000269|PubMed:15994300, ECO:0000269|PubMed:16636052, ECO:0000269|PubMed:19366695, ECO:0000269|PubMed:22529353, ECO:0000269|PubMed:35525268}.; FUNCTION: [Isoform 2]: Zinc ion:proton antiporter mediating influx and efflux of zinc at the plasma membrane. {ECO:0000269|PubMed:11937503, ECO:0000269|PubMed:17355957}.
uniprot
proteins
mass_dalton
84047
uniprot
proteins
mutagenesis
MUTAGEN 451; /note="H->A: Loss of zinc transporter activity."; /evidence="ECO:0000269|PubMed:19366695"; MUTAGEN 451; /note="H->D: No effect on zinc ion transmembrane transporter activity. No effect on zinc ion import into Golgi. Loss of specificity for zinc ions as it can also transport cadmium ions."; /evidence="ECO:0000269|PubMed:22529353"; MUTAGEN 599; /note="D->A: Loss of zinc transporter activity. No effect on localization to the trans-Golgi network."; /evidence="ECO:0000269|PubMed:19366695"; MUTAGEN 599; /note="D->E: No effect on zinc transporter activity. No effect on localization to the trans-Golgi network."; /evidence="ECO:0000269|PubMed:19366695
uniprot
proteins
post_translational_modification
PTM: Could homodimerize through the formation of dityrosine bonds upon oxidative stress. {ECO:0000269|PubMed:19521526}.
uniprot
proteins
protein_family
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
uniprot
proteins
protein_family
SLC30A subfamily
uniprot
proteins
pubmed
11904301
uniprot
proteins
pubmed
11937503
uniprot
proteins
pubmed
12095919
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15276077
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15525635
uniprot
proteins
pubmed
15994300
uniprot
proteins
pubmed
16636052
uniprot
proteins
pubmed
17355957
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19366695
uniprot
proteins
pubmed
19521526
uniprot
proteins
pubmed
19759014
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21887337
uniprot
proteins
pubmed
22529353
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25582195
uniprot
proteins
pubmed
35525268
uniprot
proteins
sequence_length
765
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:12095919, ECO:0000269|PubMed:15525635, ECO:0000269|PubMed:21887337, ECO:0000269|PubMed:22529353}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:15525635}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:11904301}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19366695}; Multi-pass membrane protein {ECO:0000255}. Lateral cell membrane {ECO:0000250|UniProtKB:Q8R4H9}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8R4H9}. Note=Enriched in early compartments of the secretory pathway including COPII-coated vesicles and the Golgi cis cisterna. {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:15525635}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21887337}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:11937503, ECO:0000269|PubMed:17355957}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:11937503}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..53; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 57..77; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 99..119; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 121..141; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 153..173; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 194..214; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 239..259; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 268..288; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 304..324; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 343..363; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 419..439; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 449..469; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 484..504; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 521..541; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 593..613; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 618..638; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins