FBXO46
entrez
23403
canonical
uniprot
Q6PJ61
canonical
ensembl
ENSG00000177051
resolver
ensp
ENSP00000410007
resolver
ensp
ENSP00000595283
resolver
ensp
ENSP00000595284
resolver
ensp
ENSP00000595285
resolver
ensp
ENSP00000789923
resolver
enst
ENST00000317683
resolver
enst
ENST00000925224
resolver
enst
ENST00000925225
resolver
enst
ENST00000925226
resolver
genesymbol
FBXO46
resolver
genesymbol_syn
FBX46
resolver
genesymbol_syn
FBXO34L
resolver
hgnc
HGNC:25069
resolver
uniprot_entry
FBX46_HUMAN
resolver
amino_acid_sequence
MDRGSLLPFQLWCPRPFGTYSQNQPRPPSAALKPSACPEPGGGAEPDHGPAHSENTPPALATEVPASQPAPLLSAAAAGDEGRVLLDTWYVIKPGNTKEKVAFFVAHQCGGGSRASSMKVKGHWGSDSSKAKRRRRCLDPTKAPPDPGGREGPPAAEEGPASAGEDVDLLSVAEMVALVEQRAALALQSYPRPTTPAPVVFVSAEQGGPAKGVGSERRSGGGDCSRVAEAVAHFEAQRDSPPTKGLRKEERPGPGPGEVRIAFRISNGREPRAPDSGLPSGGGGRPGCAYPGSPGPGARAKDKITCDLYQLISPSRDALPSNVEFLLARADEASEGDSPAPARPEDTPPAPPPPPARDCGASGFHVDVVVTGVVDECIFFGKDGTKNVKEETVCLTVSPEEPPPPGQLFFLQNRGPDGPPEPPPADSPATAPGPDDAEGTADTSLCRLYRHVSHDFLEIRFKIQRLLEPRQYMLLLPEHVLVKIFSFLPTRALAALKCTCHHFKGIIEAFGVRATDSRWSRDPLYRDDPCKQCRKRYEKGDVSLCRWHPKPYHHDLPYGRSYWMCCRRADRETPGCRLGLHDNNWVLPCNGPGGGRAGREEGR
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}.
uniprot
proteins
mass_dalton
64631
uniprot
proteins
mutagenesis
MUTAGEN 21; /note="S->A: Decreased degradation in response to genotoxic stress."; /evidence="ECO:0000269|PubMed:30171069"; MUTAGEN 67; /note="S->A: Decreased degradation in response to genotoxic stress."; /evidence="ECO:0000269|PubMed:30171069"; MUTAGEN 216; /note="E->A: Does not affect interaction with FBXO31."; /evidence="ECO:0000269|PubMed:30171069"; MUTAGEN 217; /note="R->A: Decreased interaction with FBXO31; when associated with 440-A--A-442."; /evidence="ECO:0000269|PubMed:30171069"; MUTAGEN 440..442; /note="TAD->AAA: Decreased interaction with FBXO31; when associated with A-217."; /evidence="ECO:0000269|PubMed:30171069
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:30171069}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ATM in response to DNA damage, promoting ubiquitination and degradation by the SCF(FBXO31) complex. {ECO:0000269|PubMed:30171069}.; PTM: ATM-phosphorylated FBXO46 is ubiquitinated and degradaded by the SCF(FBXO31) complex in response to DNA damage. {ECO:0000269|PubMed:30171069}.
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30171069
uniprot
proteins
sequence_length
603
uniprot
proteins