Hbs1l
entrez
56422
canonical
uniprot
Q69ZS7
canonical
ensembl
ENSMUSG00000019977
resolver
ensp
ENSMUSP00000020153
resolver
ensp
ENSMUSP00000090344
resolver
ensp
ENSMUSP00000135902
resolver
ensp
ENSMUSP00000151689
resolver
ensp
ENSMUSP00000295958
resolver
ensp
ENSMUSP00000295970
resolver
enst
ENSMUST00000020153
resolver
enst
ENSMUST00000061324
resolver
enst
ENSMUST00000092674
resolver
genesymbol
Hbs1l
resolver
genesymbol_syn
Gm9923
resolver
genesymbol_syn
Hbs1
resolver
genesymbol_syn
Kiaa1038
resolver
uniprot
A0A1X7SB57
resolver
uniprot
J3KMK0
resolver
uniprot
L7N209
resolver
uniprot
Q3TGM7
resolver
uniprot
Q91Z32
resolver
uniprot
Q9CVT2
resolver
uniprot
Q9CZ95
resolver
uniprot
Q9WTY5
resolver
uniprot_entry
A0A1X7SB57_MOUSE
resolver
uniprot_entry
HBS1L_MOUSE
resolver
uniprot_entry
J3KMK0_MOUSE
resolver
uniprot_entry
L7N209_MOUSE
resolver
uniprot_entry
Q3TGM7_MOUSE
resolver
uniprot_sec
Q91Z32
resolver
uniprot_sec
Q9CVT2
resolver
uniprot_sec
Q9CZ95
resolver
uniprot_sec
Q9WTY5
resolver
amino_acid_sequence
MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDNPEEEYGYEDLRESSNSLLNHQLSEIDQARLYSCLDHMREVLGDAVPDDILTEAILKHKFDVQKALSVVLEQDGVQPWKEKSERAVCAGQPSKGKSVISRSSQSESEIVPKVAKMTVSGKKQTMGFEVPGLTSEENGLSVRAPHKGPPGDDVSVASPNIPETGTPKSALPPPSLQTSEELGSTPTPVRKSGKLRQQIDVKAELEKRQGGKQLLNLVVIGHVDAGKSTLMGHMLYLLGNVNKRTMHKYEQESKKAGKASFAYAWVLDETGEERERGVTMDVGMTKFETTTKVITLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMDQVNWQQERFQEITGKLGHFLKQAGFKESDVAFIPTSGLSGENLTARSQSSDLTTWYKGMCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQGSGFCVTGKIEAGYIQTGDRLLAMPPNETCTAKGITLHDEPVDWAAAGDHVNLTLVGMDIIKINVGCIFCGPKEPIKACTRFRARILVFNIEVPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTKKKPKLLTKGQNALVELQTQRPVALELYKDFKELGRFMLRYGGSTVAAGVVTEIKE
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. {ECO:0000250|UniProtKB:Q9Y450}.
uniprot
proteins
mass_dalton
75100
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
33899734
uniprot
proteins
pubmed
9872408
uniprot
proteins
sequence_length
682
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y450}.
uniprot
proteins