Fer
entrez
14158
canonical
uniprot
P70451
canonical
ensembl
ENSMUSG00000000127
resolver
ensp
ENSMUSP00000000129
resolver
ensp
ENSMUSP00000037418
resolver
ensp
ENSMUSP00000156416
resolver
ensp
ENSMUSP00000156523
resolver
ensp
ENSMUSP00000170701
resolver
ensp
ENSMUSP00000170702
resolver
ensp
ENSMUSP00000170703
resolver
ensp
ENSMUSP00000170706
resolver
enst
ENSMUST00000232945
resolver
genesymbol
Fer
resolver
genesymbol_syn
Fert2
resolver
uniprot
A0A3B2WCA6
resolver
uniprot
Q3TME9
resolver
uniprot
Q3TZJ5
resolver
uniprot
Q61561
resolver
uniprot
Q6PEE5
resolver
uniprot
Q80UI3
resolver
uniprot
Q8C481
resolver
uniprot
Q9EQ77
resolver
uniprot_entry
A0A3B2WCA6_MOUSE
resolver
uniprot_entry
FER_MOUSE
resolver
uniprot_entry
Q3TME9_MOUSE
resolver
uniprot_entry
Q3TZJ5_MOUSE
resolver
uniprot_sec
Q61561
resolver
uniprot_sec
Q6PEE5
resolver
uniprot_sec
Q80UI3
resolver
uniprot_sec
Q8C481
resolver
uniprot_sec
Q9EQ77
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphatidic acid binding (By similarity). Activated by hydrogen peroxide (in vitro). Activated by reactive oxygen species (ROS). {ECO:0000250, ECO:0000269|PubMed:16731527, ECO:0000269|PubMed:17606629}.
uniprot
proteins
amino_acid_sequence
MGFGSDLKNSQEAVLKLQDWELRLLETVKKFMALRIKSDKEYAYTLQNLCNQVDKESTVQVNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYVGIHQQIEAEMIKVTKTELEKLKSSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQSQYYDTTLPLLLDSVQKMQEEMIKALKGIFDDYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTADSLQVMLKTLAEELTQTQQMLLHKEAAVLELEKRIEESFETCEKKSDIVLLLGQKQALEELKQSVQQLRCTEAKCAAQKALLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIKSPKSVLGSSTQVCDVISVGERPLAEHDWYHGAIPRIEAQELLKQQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQFVDNLYRFEGTGFSNIPQLIDHHFNTKQVITKKSGVVLLNPIPKDKKWVLNHEDVSLGELLGKGNFGEVYKGTLKDKTPVAIKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVPGGDFLTFLRKRKDELKLKQLVRFSLDVAAGMLYLESKNCIHRDLAARNCLVGENNTLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQNCPEEVFTIMMKCWDYKPENRPKFNDLHKELTVIKKMIT
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3 according to PubMed:10878010 and PubMed:19159681, but clearly plays a redundant role in STAT3 phosphorylation. According to PubMed:11134346, cells where wild type FER has been replaced by a kinase-dead mutant show no reduction in STAT3 phosphorylation. Phosphorylates TMF1. Isoform 3 lacks kinase activity. {ECO:0000269|PubMed:10878010, ECO:0000269|PubMed:11006284, ECO:0000269|PubMed:11994443, ECO:0000269|PubMed:15226396, ECO:0000269|PubMed:16176974, ECO:0000269|PubMed:16731527, ECO:0000269|PubMed:16732323, ECO:0000269|PubMed:17606629, ECO:0000269|PubMed:19159681, ECO:0000269|PubMed:20133938, ECO:0000269|PubMed:7623846, ECO:0000269|PubMed:9742951}.
uniprot
proteins
mass_dalton
94579
uniprot
proteins
mutagenesis
MUTAGEN 135..136; /note="KL->RP: Abolishes homooligomerization."; /evidence="ECO:0000269|PubMed:10391941"; MUTAGEN 322..323; /note="ML->RP: Abolishes homooligomerization."; /evidence="ECO:0000269|PubMed:10391941"; MUTAGEN 571; /note="G->R: Abolishes kinase activity."; /evidence="ECO:0000269|PubMed:9742951"; MUTAGEN 592; /note="K->R: Abolishes kinase activity."; /evidence="ECO:0000269|PubMed:10391941"; MUTAGEN 606; /note="F->A: Abolishes interaction with PPP1CA."; /evidence="ECO:0000269|PubMed:16732323"; MUTAGEN 616; /note="Y->F: Abolishes autophosphorylation."; /evidence="ECO:0000269|PubMed:19159681"; MUTAGEN 715; /note="Y->F: Abolishes autophosphorylation."; /evidence="ECO:0000269|PubMed:10074905"; MUTAGEN 743; /note="D->R: Abolishes kinase activity."; /evidence="ECO:0000269|PubMed:10391941
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000269|PubMed:10074905, ECO:0000269|PubMed:16176974, ECO:0000269|PubMed:16731527, ECO:0000269|PubMed:19159681}.; PTM: Polyubiquitinated; this leads to proteasomal degradation. {ECO:0000269|PubMed:19159681}.
uniprot
proteins
protein_family
Fes/fps subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10074905
uniprot
proteins
pubmed
10391941
uniprot
proteins
pubmed
10878010
uniprot
proteins
pubmed
11006284
uniprot
proteins
pubmed
11134346
uniprot
proteins
pubmed
11339827
uniprot
proteins
pubmed
11994443
uniprot
proteins
pubmed
12200133
uniprot
proteins
pubmed
12738762
uniprot
proteins
pubmed
12901971
uniprot
proteins
pubmed
15226396
uniprot
proteins
pubmed
15467733
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16176974
uniprot
proteins
pubmed
16731527
uniprot
proteins
pubmed
16732323
uniprot
proteins
pubmed
17606629
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19159681
uniprot
proteins
pubmed
20133938
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2294399
uniprot
proteins
pubmed
7623846
uniprot
proteins
pubmed
9742951
uniprot
proteins
sequence_length
823
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection {ECO:0000250}. Cell junction {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus. Cytoplasm, cell cortex {ECO:0000250}. Note=Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts (By similarity). Not detected in the nucleus, but detected in the nuclear area surrounding the chromosomes after breakdown of the nuclear envelope during mitosis (PubMed:11339827). {ECO:0000250, ECO:0000269|PubMed:11339827}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus.
uniprot
proteins