Thoc1
entrez
225160
canonical
uniprot
Q8R3N6
canonical
ensembl
ENSMUSG00000024287
resolver
ensp
ENSMUSP00000025137
resolver
ensp
ENSMUSP00000236427
resolver
ensp
ENSMUSP00000236434
resolver
enst
ENSMUST00000025137
resolver
genesymbol
Thoc1
resolver
genesymbol_syn
Hpr1
resolver
uniprot
Q8BWD5
resolver
uniprot
Q8BXY3
resolver
uniprot_entry
THOC1_MOUSE
resolver
uniprot_sec
Q8BWD5
resolver
uniprot_sec
Q8BXY3
resolver
amino_acid_sequence
MSPTPALFSLPEARTRFTKSTREALNNKNIKPLLTAFSQLPGSENEKKCTLDQAFRGVLEEEIINHSACENVLAIISLAIGGVTESVCTASTPFVLLGDVLDCLPLDQCDTIFTFVEKNVATWKSNTFYSAGKNYLLRMCNDLLRRLSKSQNTVFCGRIQLFLARLFPLSEKSGLNLQSQFNLENVTVFNTNEQESTLGQKHTEDREEGMDVEEGEMGDDEAPTTCSIPIDYNLYRKFWSLQDYFRNPVQCYEKISWKTFLKYSEEVLAVFKSYKLDDTQASRKKMEELKTGGEHVYFAKFLTSEKLMDLQLSDSNFRRHILLQYLILFQYLKGQVKFKSSNYVLTDEQSLWIEDTTKSVYQLLSENPPDGERFSKMVEHILNTEENWNSWKNEGCPSFVKERASDTKPTRVVRKRAAPEDFLGKGPNKKILIGNEELTRLWNLCPDNMEACKSETREYMPTLEEFFEEAIEQADPENMVESEYKAVNNSNYGWRALRLLARRSPHFFQPTNQQFKSLPEYLENMVIKLAKELPPPSEEIKTGEDEDEEDNDALLKENESPDVRRDKPITGEQIESFANKLGEQWKILAPYLEIKDSDIRQIECDSEDMKMRAKQLLVAWQDQEGVHATTDNLISALNKSGLSDLAESLTNDTETNS
uniprot
proteins
function
FUNCTION: Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (By similarity). Required for efficient export of polyadenylated RNA (By similarity). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B (By similarity). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (By similarity). Regulates transcriptional elongation of a subset of genes (By similarity). Involved in genome stability by preventing co-transcriptional R-loop formation (By similarity). May play a role in hair cell formation, hence may be involved in hearing (By similarity). {ECO:0000250|UniProtKB:Q7SYB2, ECO:0000250|UniProtKB:Q96FV9}.; FUNCTION: Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1 (By similarity). Essential for early embryonic development. Required for normal gene expression during postnatal testis development. {ECO:0000250, ECO:0000269|PubMed:16705185, ECO:0000269|PubMed:19307311}.
uniprot
proteins
mass_dalton
75436
uniprot
proteins
post_translational_modification
PTM: Expression is altered specifically during apoptosis and is accompanied by the appearance of novel forms with smaller apparent molecular mass. {ECO:0000250}.; PTM: Polyubiquitinated, leading to proteasomal degradation; probably involves NEDD4. {ECO:0000250}.
uniprot
proteins
protein_family
THOC1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16705185
uniprot
proteins
pubmed
16909111
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19307311
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32776944
uniprot
proteins
sequence_length
657
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32776944}. Nucleus, nucleoplasm {ECO:0000269|PubMed:16705185}. Nucleus matrix {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:32776944}. Note=Predominantly localized in the nucleus (PubMed:32776944). Shuttles between the nucleus and cytosol. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution (By similarity). {ECO:0000250, ECO:0000269|PubMed:32776944}.
uniprot
proteins