PDK3
entrez
5165
canonical
uniprot
Q15120
canonical
ensembl
ENSG00000067992
resolver
ensp
ENSP00000368460
resolver
ensp
ENSP00000498864
resolver
genesymbol
PDK3
resolver
genesymbol_syn
PDHK3
resolver
hgnc
HGNC:8811
resolver
uniprot
B4DXG6
resolver
uniprot_entry
PDK3_HUMAN
resolver
uniprot_sec
B4DXG6
resolver
activity_regulation
ACTIVITY REGULATION: Activated by interaction with DLAT. Inhibited by AZD7545, dichloroacetate and radicicol. {ECO:0000269|PubMed:10748134, ECO:0000269|PubMed:17683942}.
uniprot
proteins
amino_acid_sequence
MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQ
uniprot
proteins
disease_involvement
DISEASE: Charcot-Marie-Tooth disease, X-linked dominant, 6 (CMTX6) [MIM:300905]: A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies characterized by severely reduced motor nerve conduction velocities (NCVs) (less than 38m/s) and segmental demyelination and remyelination, and primary peripheral axonal neuropathies characterized by normal or mildly reduced NCVs and chronic axonal degeneration and regeneration on nerve biopsy. {ECO:0000269|PubMed:23297365}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.2
uniprot
proteins
function
FUNCTION: Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. {ECO:0000269|PubMed:10748134, ECO:0000269|PubMed:11486000, ECO:0000269|PubMed:15861126, ECO:0000269|PubMed:16436377, ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18718909, ECO:0000269|PubMed:22865452}.
uniprot
proteins
mass_dalton
46939
uniprot
proteins
mutagenesis
MUTAGEN 120; /note="N->H: No effect on kinase activity; when associated with N-121."; /evidence="ECO:0000269|PubMed:23297365"; MUTAGEN 121; /note="D->N: No effect on kinase activity; when associated with H-120."; /evidence="ECO:0000269|PubMed:23297365
uniprot
proteins
protein_family
PDK/BCKDK protein kinase family
uniprot
proteins
pubmed
10748134
uniprot
proteins
pubmed
11486000
uniprot
proteins
pubmed
11978179
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15861126
uniprot
proteins
pubmed
16436377
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17532006
uniprot
proteins
pubmed
17669420
uniprot
proteins
pubmed
17683942
uniprot
proteins
pubmed
18718909
uniprot
proteins
pubmed
20715114
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22865452
uniprot
proteins
pubmed
23297365
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7499431
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix.
uniprot
proteins