Cops5
entrez
26754
canonical
uniprot
O35864
canonical
ensembl
ENSMUSG00000025917
resolver
ensp
ENSMUSP00000027050
resolver
enst
ENSMUST00000027050
resolver
genesymbol
Cops5
resolver
genesymbol_syn
Csn5
resolver
genesymbol_syn
Jab1
resolver
genesymbol_syn
Kic2
resolver
uniprot
Q3UA70
resolver
uniprot
Q8C1S1
resolver
uniprot_entry
CSN5_MOUSE
resolver
uniprot_sec
Q3UA70
resolver
uniprot_sec
Q8C1S1
resolver
amino_acid_sequence
MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINVA
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Promotes the proteasomal degradation of BRSK2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. {ECO:0000250|UniProtKB:Q92905}.
uniprot
proteins
mass_dalton
37549
uniprot
proteins
mutagenesis
MUTAGEN 151; /note="D->N: Abolishes ability to deneddylate cullins, but keeps ability to stabilize HIF1A protein."; /evidence="ECO:0000269|PubMed:15082527
uniprot
proteins
protein_family
CSN5 subfamily
uniprot
proteins
protein_family
Peptidase M67A family
uniprot
proteins
pubmed
10086358
uniprot
proteins
pubmed
10721695
uniprot
proteins
pubmed
11707426
uniprot
proteins
pubmed
15082527
uniprot
proteins
pubmed
15451666
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9341143
uniprot
proteins
pubmed
9707402
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10721695}. Nucleus {ECO:0000269|PubMed:10721695}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q92905}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q92905}. Note=Nuclear localization is diminished in the presence of IFIT3. {ECO:0000250|UniProtKB:Q92905}.
uniprot
proteins