Ercc8
entrez
71991
canonical
uniprot
Q8CFD5
canonical
ensembl
ENSMUSG00000021694
resolver
ensp
ENSMUSP00000059211
resolver
ensp
ENSMUSP00000279673
resolver
ensp
ENSMUSP00000359101
resolver
enst
ENSMUST00000054835
resolver
genesymbol
Ercc8
resolver
genesymbol_syn
Ckn1
resolver
genesymbol_syn
Csa
resolver
uniprot
Q3TZV2
resolver
uniprot
Q3U066
resolver
uniprot
Q8VDC4
resolver
uniprot
Q9CWK7
resolver
uniprot_entry
ERCC8_MOUSE
resolver
uniprot_entry
Q3TZV2_MOUSE
resolver
uniprot_sec
Q3U066
resolver
uniprot_sec
Q8VDC4
resolver
uniprot_sec
Q9CWK7
resolver
amino_acid_sequence
MLSFLSARQSGLEDPLRLRRAQSTRRVLGLELNKDRDVERIHGSGVNTLDIEPVEGRYMLSGGSDGVVVLYDLENASRQPHYTCKAVCSVGRSHPDVHKYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQAADVFNFEETVYSHHMSPAATKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYILATASADSRVKLWDVRRASGCLLTLDQHNGKKSQAAESANTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSSSGDNTLVNYGKVCNDSRKGLQFAVSCGCSSEFVFVPHGSTIAVYAVHSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAWVPPSYEPVPDDDDEAPAKSQLNPAFADAWSSSDEDG
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes. Following recruitment to lesion-stalled RNA polymerase II (Pol II), the CSA complex mediates ubiquitination of Pol II subunit POLR2A/RPB1 at 'Lys-1268', a critical TC-NER checkpoint, governing RNA Pol II stability and initiating DNA damage excision by TFIIH recruitment. The CSA complex also promotes the ubiquitination and subsequent proteasomal degradation of ERCC6/CSB in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. Also plays a role in DNA double-strand breaks (DSSBs) repair by non-homologous end joining (NHEJ). {ECO:0000250|UniProtKB:Q13216}.
uniprot
proteins
mass_dalton
43689
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q13216}.
uniprot
proteins
pubmed
12509261
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13216}. Chromosome {ECO:0000250|UniProtKB:Q13216}. Nucleus matrix {ECO:0000250|UniProtKB:Q13216}. Note=Recruited to lesion-stalled RNA polymerase II (Pol II) sites by ERCC6/CSB. UV-induced translocation to the nuclear matrix is dependent on ERCC6/CSB. {ECO:0000250|UniProtKB:Q13216}.
uniprot
proteins