SOCS7
entrez
30837
canonical
uniprot
O14512
canonical
ensembl
ENSG00000274211
resolver
ensembl
ENSG00000274229
resolver
ensp
ENSP00000482229
resolver
ensp
ENSP00000484381
resolver
enst
ENST00000612932
resolver
genesymbol
SOCS7
resolver
genesymbol_syn
NAP4
resolver
genesymbol_syn
SOCS6
resolver
hgnc
HGNC:29846
resolver
uniprot
A0A5F9YLF9
resolver
uniprot
A2VCU2
resolver
uniprot
Q0IJ63
resolver
uniprot_entry
A0A5F9YLF9_HUMAN
resolver
uniprot_entry
SOCS7_HUMAN
resolver
uniprot_sec
A2VCU2
resolver
uniprot_sec
Q0IJ63
resolver
amino_acid_sequence
MVFRNVGRPPEEEDVEAAPEPGPSELLCPRHRCALDPKALPPGLALERTWGPAAGLEAQLAALGLGQPAGPGVKTVGGGCCPCPCPPQPPPPQPQPPAAAPQAGEDPTETSDALLVLEGLESEAESLETNSCSEEELSSPGRGGGGGGRLLLQPPGPELPPVPFPLQDLVPLGRLSRGEQQQQQQQQPPPPPPPPGPLRPLAGPSRKGSFKIRLSRLFRTKSCNGGSGGGDGTGKRPSGELAASAASLTDMGGSAGRELDAGRKPKLTRTQSAFSPVSFSPLFTGETVSLVDVDISQRGLTSPHPPTPPPPPRRSLSLLDDISGTLPTSVLVAPMGSSLQSFPLPPPPPPHAPDAFPRIAPIRAAESLHSQPPQHLQCPLYRPDSSSFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIPDLPLPKPLISYIRKFYYYDPQEEVYLSLKEAQLISKQKQEVEPST
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1 (PubMed:16127460). Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination (By similarity). The ECS(SOCS7) complex acts as a key regulator of reelin signaling by mediating ubiquitination and degradation of phosphorylated DAB1 in the cortical plate of the developing cerebral cortex, thereby regulating neuron positioning during cortex development (By similarity). Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation (PubMed:16127460). Also inhibits prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA (PubMed:15677474). {ECO:0000250|UniProtKB:Q8VHQ2, ECO:0000269|PubMed:15677474, ECO:0000269|PubMed:16127460}.
uniprot
proteins
mass_dalton
62969
uniprot
proteins
mutagenesis
MUTAGEN 425..427; /note="RDS->KDC: Loss of IRS1 ubiquitination and degradation."; /evidence="ECO:0000269|PubMed:16127460
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:16127460}.
uniprot
proteins
pubmed
10969179
uniprot
proteins
pubmed
15242778
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15677474
uniprot
proteins
pubmed
16127460
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17803907
uniprot
proteins
pubmed
9344857
uniprot
proteins
sequence_length
581
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15242778, ECO:0000269|PubMed:17803907}. Nucleus {ECO:0000269|PubMed:17803907}. Cell membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:15242778}. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus (PubMed:17803907). Rapidly relocalizes to the nucleus after UV irradiation (PubMed:17803907). Cytoplasmic location depends upon SEPT7 presence (PubMed:17803907). {ECO:0000269|PubMed:17803907}.
uniprot
proteins