ANXA2
entrez
302
canonical
uniprot
P07355
canonical
ensembl
ENSG00000182718
resolver
ensp
ENSP00000346032
resolver
ensp
ENSP00000379342
resolver
ensp
ENSP00000387545
resolver
ensp
ENSP00000411352
resolver
ensp
ENSP00000453039
resolver
ensp
ENSP00000453869
resolver
enst
ENST00000558985
resolver
enst
ENST00000559113
resolver
genesymbol
ANXA2
resolver
genesymbol_syn
ANX2
resolver
genesymbol_syn
ANX2L4
resolver
genesymbol_syn
CAL1H
resolver
genesymbol_syn
LPC2D
resolver
hgnc
HGNC:537
resolver
uniprot
A0A024R5Z7
resolver
uniprot
H0YL33
resolver
uniprot
H0YN52
resolver
uniprot
Q567R4
resolver
uniprot
Q6N0B3
resolver
uniprot
Q8TBV2
resolver
uniprot
Q96DD5
resolver
uniprot
Q9UDH8
resolver
uniprot_entry
A0A024R5Z7_HUMAN
resolver
uniprot_entry
ANXA2_HUMAN
resolver
uniprot_entry
H0YL33_HUMAN
resolver
uniprot_sec
H0YN52
resolver
uniprot_sec
Q567R4
resolver
uniprot_sec
Q6N0B3
resolver
uniprot_sec
Q8TBV2
resolver
uniprot_sec
Q96DD5
resolver
uniprot_sec
Q9UDH8
resolver
amino_acid_sequence
MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
uniprot
proteins
disease_involvement
DISEASE: Note=Increased expression of ANXA2 is associated with hepatocellular carcinoma tumor progression. {ECO:0000269|PubMed:27121050}.
uniprot
proteins
function
FUNCTION: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}.
uniprot
proteins
mass_dalton
38604
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="Y->A: Abolishes heat stress-induced cell surface localization."; /evidence="ECO:0000269|PubMed:15302870"; MUTAGEN 26; /note="S->E: Stronger interaction with S100A4."; /evidence="ECO:0000269|PubMed:28669632"; MUTAGEN 28..36; /note="KAYTNFDAE->SAYTNFNAS: No effect on interaction with PCSK9."; /evidence="ECO:0000269|PubMed:22848640"; MUTAGEN 37..47; /note="RDALNIETAIK->SDALNIHTAIM: Slightly decreases interaction with PCSK9."; /evidence="ECO:0000269|PubMed:22848640"; MUTAGEN 77..81; /note="RRTKK->AATAA: Strongly decreases interaction with PCSK9."; /evidence="ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640"; MUTAGEN 77..80; /note="RRTK->AATA: Decreases interaction with PCSK9. Strongly decreases interaction with PCSK9; when associated with K-88."; /evidence="ECO:0000269|PubMed:18799458"; MUTAGEN 80..84; /note="KKELA->GKPLD: No effect on interaction with PCSK9."; /evidence="ECO:0000269|PubMed:18799458"; MUTAGEN 88; /note="K->A: Strongly decreases interaction with PCSK9; when associated with 77-A--A-80."; /evidence="ECO:0000269|PubMed:18799458
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. {ECO:0000269|PubMed:15302870, ECO:0000269|PubMed:2946940}.; PTM: ISGylated. {ECO:0000269|PubMed:16139798}.
uniprot
proteins
protein_family
Annexin family
uniprot
proteins
pubmed
14522961
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
15302870
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16139798
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
1825830
uniprot
proteins
pubmed
18799458
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2174397
uniprot
proteins
pubmed
21886777
uniprot
proteins
pubmed
22848640
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24808179
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25139904
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27121050
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28669632
uniprot
proteins
pubmed
2946940
uniprot
proteins
pubmed
3013422
uniprot
proteins
pubmed
33310911
uniprot
proteins
pubmed
8110754
uniprot
proteins
pubmed
8117306
uniprot
proteins
pubmed
8449982
uniprot
proteins
pubmed
8636985
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.
uniprot
proteins