Hpn
entrez
15451
canonical
uniprot
O35453
canonical
ensembl
ENSMUSG00000001249
resolver
ensp
ENSMUSP00000038149
resolver
ensp
ENSMUSP00000103737
resolver
ensp
ENSMUSP00000131658
resolver
enst
ENSMUST00000039435
resolver
enst
ENSMUST00000168884
resolver
genesymbol
Hpn
resolver
uniprot
B2RSC4
resolver
uniprot
E9Q5P0
resolver
uniprot
G3UWE8
resolver
uniprot
Q9CW97
resolver
uniprot_entry
E9Q5P0_MOUSE
resolver
uniprot_entry
G3UWE8_MOUSE
resolver
uniprot_entry
HEPS_MOUSE
resolver
uniprot_sec
B2RSC4
resolver
uniprot_sec
Q9CW97
resolver
amino_acid_sequence
MAKEDEEPGAHRGGSTCSRPQPGKGGRTAACCSRPKVAALIVGTLLFLTGIGAASWAIVTILLQSDQEPLYQVQLSPGDSRLAVFDKTEGTWRLLCSSRSNARVAGLGCEEMGFLRALAHSELDVRTAGANGTSGFFCVDEGGLPLAQRLLDVISVCDCPRGRFLTATCQDCGRRKLPVDRIVGGQDSSLGRWPWQVSLRYDGTHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVARTSPHAVQLGVQAVIYHGGYLPFRDPTIDENSNDIALVHLSSSLPLTEYIQPVCLPAAGQALVDGKVCTVTGWGNTQFYGQQAMVLQEARVPIISNEVCNSPDFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISGTSRWRLCGIVSWGTGCALARKPGVYTKVTDFREWIFKAIKTHSEASGMVTQP
uniprot
proteins
ec_number
3.4.21.106
uniprot
proteins
function
FUNCTION: Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL. Plays a role in cell growth and maintenance of cell morphology. Plays a role in the proteolytic processing of ACE2 (By similarity). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890). {ECO:0000250|UniProtKB:P05981, ECO:0000269|PubMed:26673890}.
uniprot
proteins
mass_dalton
46821
uniprot
proteins
mutagenesis
MUTAGEN 372; /note="S->A: Abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:9395459
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10411637
uniprot
proteins
pubmed
11127869
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17620368
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26673890
uniprot
proteins
pubmed
9395459
uniprot
proteins
pubmed
9435303
uniprot
proteins
sequence_length
436
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:26673890}; Single-pass type II membrane protein {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P05981}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P05981}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:9395459}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins