HYPK
entrez
25764
canonical
uniprot
Q9NX55
canonical
ensembl
ENSG00000242028
resolver
ensp
ENSP00000401155
resolver
ensp
ENSP00000775278
resolver
genesymbol
HYPK
resolver
genesymbol_syn
C15orf63
resolver
hgnc
HGNC:18418
resolver
uniprot
C9JKJ0
resolver
uniprot
O75408
resolver
uniprot
Q8WUW8
resolver
uniprot
Q9P024
resolver
uniprot_entry
HYPK_HUMAN
resolver
uniprot_sec
C9JKJ0
resolver
uniprot_sec
O75408
resolver
uniprot_sec
Q8WUW8
resolver
uniprot_sec
Q9P024
resolver
amino_acid_sequence
MATEGDVELELETETSGPERPPEKPRKHDSGAADLERVTDYAEEKEIQSSNLETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMTEMEISRAAAERSLREHMGNVVEALIALTN
uniprot
proteins
function
FUNCTION: Component of several N-terminal acetyltransferase complexes (PubMed:20154145, PubMed:29754825, PubMed:32042062). Inhibits the N-terminal acetylation activity of the N-terminal acetyltransferase NAA10-NAA15 complex (also called the NatA complex) (PubMed:29754825, PubMed:32042062). Has chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT in neuronal cells probably while associated with the NatA complex (PubMed:17947297, PubMed:20154145). May play a role in the NatA complex-mediated N-terminal acetylation of PCNP (PubMed:20154145). {ECO:0000269|PubMed:17947297, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}.
uniprot
proteins
mass_dalton
13651
uniprot
proteins
mutagenesis
MUTAGEN 28; /note="H->A: Reduces ability to inhibit NAA10-NAA15 complex-mediated N-terminal acetylation, which results in increased N-terminal acetylation."; /evidence="ECO:0000269|PubMed:29754825"; MUTAGEN 35; /note="L->A: Reduces ability to inhibit NAA10-NAA15 complex-mediated N-terminal acetylation, which results in increased N-terminal acetylation; when associated with A-38."; /evidence="ECO:0000269|PubMed:29754825"; MUTAGEN 38; /note="V->A: Reduces ability to inhibit NAA10-NAA15 complex-mediated N-terminal acetylation, which results in increased N-terminal acetylation; when associated with A-35."; /evidence="ECO:0000269|PubMed:29754825"; MUTAGEN 52..121; /note="Missing: Abolishes interaction with NAA10 and NAA15."; /evidence="ECO:0000269|PubMed:29754825
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17947297
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20154145
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29754825
uniprot
proteins
pubmed
32042062
uniprot
proteins
pubmed
9700202
uniprot
proteins
sequence_length
121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20154145}. Cytoplasm {ECO:0000269|PubMed:20154145}. Note=Within the NatA/HYPK complex, may localize to ribosomes. {ECO:0000269|PubMed:20154145}.
uniprot
proteins