SNX27
entrez
81609
canonical
uniprot
Q96L92
canonical
ensembl
ENSG00000143376
resolver
ensp
ENSP00000357831
resolver
ensp
ENSP00000357836
resolver
ensp
ENSP00000400333
resolver
ensp
ENSP00000496645
resolver
ensp
ENSP00000561389
resolver
ensp
ENSP00000561390
resolver
ensp
ENSP00000655820
resolver
enst
ENST00000642376
resolver
genesymbol
SNX27
resolver
genesymbol_syn
KIAA0488
resolver
hgnc
HGNC:20073
resolver
uniprot
A0A2R8Y8A7
resolver
uniprot
Q32Q36
resolver
uniprot
Q4AEJ5
resolver
uniprot
Q5VWB0
resolver
uniprot
Q5VWB1
resolver
uniprot
Q5VWB2
resolver
uniprot
Q6IPP6
resolver
uniprot
Q86UB1
resolver
uniprot
Q96D79
resolver
uniprot
Q9H3K8
resolver
uniprot_entry
A0A2R8Y8A7_HUMAN
resolver
uniprot_entry
SNX27_HUMAN
resolver
uniprot_sec
Q32Q36
resolver
uniprot_sec
Q4AEJ5
resolver
uniprot_sec
Q5VWB0
resolver
uniprot_sec
Q5VWB1
resolver
uniprot_sec
Q5VWB2
resolver
uniprot_sec
Q6IPP6
resolver
uniprot_sec
Q86UB1
resolver
uniprot_sec
Q96D79
resolver
uniprot_sec
Q9H3K8
resolver
amino_acid_sequence
MADEDGEGIHPSAPHRNGGGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQAVPISVPRYKHVEQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELRVALPDGTTVTVRVKKNSTTDQVYQAIAAKVGMDSTTVNYFALFEVISHSFVRKLAPNEFPHKLYIQNYTSAVPGTCLTIRKWLFTTEEEILLNDNDLAVTYFFHQAVDDVKKGYIKAEEKSYQLQKLYEQRKMVMYLNMLRTCEGYNEIIFPHCACDSRRKGHVITAISITHFKLHACTEEGQLENQVIAFEWDEMQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKWRKENIFQMARSQQRDVAT
uniprot
proteins
function
FUNCTION: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. {ECO:0000269|PubMed:17351151, ECO:0000269|PubMed:20733053, ECO:0000269|PubMed:21300787, ECO:0000269|PubMed:21303929, ECO:0000269|PubMed:21602791, ECO:0000269|PubMed:21926430, ECO:0000269|PubMed:22411990, ECO:0000269|PubMed:23563491}.
uniprot
proteins
mass_dalton
61265
uniprot
proteins
mutagenesis
MUTAGEN 114; /note="H->A: Abolishes interaction with ADRB2, sorting and recycling of ADRB2."; /evidence="ECO:0000269|PubMed:20733053
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
15466885
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17351151
uniprot
proteins
pubmed
17577583
uniprot
proteins
pubmed
17644068
uniprot
proteins
pubmed
19555689
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20733053
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21300787
uniprot
proteins
pubmed
21303929
uniprot
proteins
pubmed
21602791
uniprot
proteins
pubmed
21926430
uniprot
proteins
pubmed
22411990
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23563491
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25851603
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9455484
uniprot
proteins
sequence_length
541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:25851603}; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products.
uniprot
proteins