Slc39a2
entrez
214922
canonical
uniprot
G3X943
canonical
ensembl
ENSMUSG00000072572
resolver
ensp
ENSMUSP00000038707
resolver
ensp
ENSMUSP00000302524
resolver
ensp
ENSMUSP00000302525
resolver
enst
ENSMUST00000047726
resolver
genesymbol
Slc39a2
resolver
genesymbol_syn
Zip2
resolver
uniprot
Q2HIZ9
resolver
uniprot_entry
S39A2_MOUSE
resolver
uniprot_sec
Q2HIZ9
resolver
amino_acid_sequence
MEVLLGVKIGCLLALLVLTLGCGLTPIYVKWFQMDAATGHHHRVLSLLGCTSAGVFLGAGLMHMTAEALEGIESEIQKFVEQNSTGSKGNSSRDAASSYVEYPYGELVISLGFFFVFLLESLALQCCHGAAGGSTVQEEEWGGTHAFGFHKHPAVPSPSRGPLRALVLLLSLSFHSVFEGLAVGLQATVAATIQLCVAVLAHKGLVVFSVGLRLGKIGTGPRWATFCILSLALMSPVGLALGLTVAGGASGQTQGLAQAVLEGIAAGTFLYVTFLEILPRELACPEAPLAKYSCVAAGFAFMALIALWA
uniprot
proteins
function
FUNCTION: Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space (PubMed:14525987). The Zn(2+) uniporter activity is independent of H(+)-driving force, but is modulated by extracellular pH and membrane potential. Transports also other divalent cations Zn(2+), Cd2(+), Cu2(+), Co2(+) in the order of decreasing affinity, respectively (By similarity). In the skin, aids in the differentiation of keratinocytes in the epidermis (PubMed:24936057). {ECO:0000250|UniProtKB:Q9NP94, ECO:0000269|PubMed:14525987, ECO:0000269|PubMed:24936057}.
uniprot
proteins
mass_dalton
32236
uniprot
proteins
protein_family
ZIP transporter (TC 2.A.5) family
uniprot
proteins
pubmed
14525987
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17506078
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24936057
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NP94}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 44..64; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 226..246; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 259..279; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins