DPP10
entrez
57628
canonical
uniprot
Q8N608
canonical
ensembl
ENSG00000175497
resolver
ensp
ENSP00000309066
resolver
ensp
ENSP00000376855
resolver
ensp
ENSP00000386565
resolver
ensp
ENSP00000387038
resolver
genesymbol
DPP10
resolver
genesymbol_syn
DPRP3
resolver
genesymbol_syn
KIAA1492
resolver
hgnc
HGNC:20823
resolver
uniprot
A8K1Q2
resolver
uniprot
B2RCJ8
resolver
uniprot
B4DKB5
resolver
uniprot
J3KPP2
resolver
uniprot
J3KQ46
resolver
uniprot
Q0GLB7
resolver
uniprot
Q0GLB8
resolver
uniprot
Q0GLB9
resolver
uniprot
Q53QT3
resolver
uniprot
Q53S86
resolver
uniprot
Q53SL8
resolver
uniprot
Q53SS4
resolver
uniprot
Q6TTV4
resolver
uniprot
Q86YR9
resolver
uniprot
Q9P236
resolver
uniprot_entry
B2RCJ8_HUMAN
resolver
uniprot_entry
B4DKB5_HUMAN
resolver
uniprot_entry
DPP10_HUMAN
resolver
uniprot_entry
Q0GLB7_HUMAN
resolver
uniprot_entry
Q0GLB9_HUMAN
resolver
uniprot_sec
A8K1Q2
resolver
uniprot_sec
J3KPP2
resolver
uniprot_sec
J3KQ46
resolver
uniprot_sec
Q0GLB8
resolver
uniprot_sec
Q53QT3
resolver
uniprot_sec
Q53S86
resolver
uniprot_sec
Q53SL8
resolver
uniprot_sec
Q53SS4
resolver
uniprot_sec
Q6TTV4
resolver
uniprot_sec
Q86YR9
resolver
uniprot_sec
Q9P236
resolver
amino_acid_sequence
MNQTASVSHHIKCQPSKTIKELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHVAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE
uniprot
proteins
disease_involvement
DISEASE: Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269|PubMed:14566338, ECO:0000269|PubMed:19237393}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155). {ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:15671030}.
uniprot
proteins
mass_dalton
90888
uniprot
proteins
mutagenesis
MUTAGEN 257; /note="N->Q: Abolishes sorting to the cell surface and dimerization."; /evidence="ECO:0000269|PubMed:22387313
uniprot
proteins
post_translational_modification
PTM: N-glycosylation is important for cell surface expression, especially at Asn-257, which is crucial. {ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:22387313}.
uniprot
proteins
protein_family
DPPIV subfamily
uniprot
proteins
protein_family
Peptidase S9B family
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
12662155
uniprot
proteins
pubmed
12675227
uniprot
proteins
pubmed
14566338
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15454437
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15671030
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16899223
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19237393
uniprot
proteins
pubmed
22387313
uniprot
proteins
sequence_length
796
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6NXK7, ECO:0000269|PubMed:14566338}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P42658}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..55; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins