GID8
entrez
54994
canonical
uniprot
Q9NWU2
canonical
ensembl
ENSG00000101193
resolver
ensp
ENSP00000266069
resolver
ensp
ENSP00000544988
resolver
ensp
ENSP00000544989
resolver
ensp
ENSP00000544991
resolver
ensp
ENSP00000544992
resolver
ensp
ENSP00000544993
resolver
ensp
ENSP00000544994
resolver
ensp
ENSP00000544995
resolver
ensp
ENSP00000544997
resolver
ensp
ENSP00000609544
resolver
ensp
ENSP00000609545
resolver
ensp
ENSP00000609547
resolver
ensp
ENSP00000609548
resolver
ensp
ENSP00000617436
resolver
ensp
ENSP00000617437
resolver
ensp
ENSP00000617438
resolver
enst
ENST00000266069
resolver
enst
ENST00000874929
resolver
enst
ENST00000874930
resolver
enst
ENST00000874932
resolver
enst
ENST00000874933
resolver
enst
ENST00000874934
resolver
enst
ENST00000874935
resolver
enst
ENST00000874936
resolver
enst
ENST00000874938
resolver
enst
ENST00000939485
resolver
enst
ENST00000939486
resolver
enst
ENST00000939488
resolver
enst
ENST00000939489
resolver
enst
ENST00000947377
resolver
enst
ENST00000947378
resolver
enst
ENST00000947379
resolver
genesymbol
GID8
resolver
genesymbol_syn
C20orf11
resolver
genesymbol_syn
TWA1
resolver
hgnc
HGNC:15857
resolver
uniprot
E1P5I3
resolver
uniprot
Q8N5M5
resolver
uniprot_entry
GID8_HUMAN
resolver
uniprot_sec
E1P5I3
resolver
uniprot_sec
Q8N5M5
resolver
amino_acid_sequence
MSYAEKPDEITKDEWMEKLNNLHVQRADMNRLIMNYLVTEGFKEAAEKFRMESGIEPSVDLETLDERIKIREMILKGQIQEAIALINSLHPELLDTNRYLYFHLQQQHLIELIRQRETEAALEFAQTQLAEQGEESRECLTEMERTLALLAFDSPEESPFGDLLHTMQRQKVWSEVNQAVLDYENRESTPKLAKLLKLLLWAQNELDQKKVKYPKMTDLSKGVIEEPK
uniprot
proteins
function
FUNCTION: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046). {ECO:0000269|PubMed:28829046, ECO:0000269|PubMed:29911972}.
uniprot
proteins
mass_dalton
26749
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated through 'Lys-48'-polyubiquitin chains, leading to proteasomal degradation in the absence of Wnt stimulation. {ECO:0000269|PubMed:28829046}.
uniprot
proteins
protein_family
GID8 family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12559565
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17467196
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24143168
uniprot
proteins
pubmed
28829046
uniprot
proteins
pubmed
29911972
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:24143168, ECO:0000269|PubMed:28829046}. Nucleus {ECO:0000269|PubMed:12559565, ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:24143168, ECO:0000269|PubMed:28829046, ECO:0000269|PubMed:29911972}. Note=Localizes in the cytoplasm in the absence of Wnt stimulation and in the nucleus in the presence of Wnt stimulation. {ECO:0000269|PubMed:28829046}.
uniprot
proteins