Madd
entrez
228355
canonical
uniprot
Q80U28
canonical
ensembl
ENSMUSG00000040687
resolver
ensp
ENSMUSP00000069350
resolver
ensp
ENSMUSP00000097311
resolver
ensp
ENSMUSP00000097313
resolver
ensp
ENSMUSP00000107001
resolver
ensp
ENSMUSP00000107004
resolver
ensp
ENSMUSP00000170247
resolver
ensp
ENSMUSP00000170248
resolver
ensp
ENSMUSP00000170249
resolver
ensp
ENSMUSP00000170250
resolver
ensp
ENSMUSP00000170252
resolver
ensp
ENSMUSP00000170253
resolver
ensp
ENSMUSP00000170254
resolver
ensp
ENSMUSP00000170255
resolver
ensp
ENSMUSP00000170256
resolver
ensp
ENSMUSP00000170257
resolver
ensp
ENSMUSP00000170258
resolver
ensp
ENSMUSP00000170259
resolver
ensp
ENSMUSP00000170260
resolver
ensp
ENSMUSP00000170261
resolver
ensp
ENSMUSP00000170262
resolver
ensp
ENSMUSP00000170263
resolver
ensp
ENSMUSP00000170264
resolver
ensp
ENSMUSP00000170266
resolver
ensp
ENSMUSP00000170267
resolver
ensp
ENSMUSP00000170269
resolver
ensp
ENSMUSP00000170270
resolver
ensp
ENSMUSP00000170271
resolver
ensp
ENSMUSP00000170272
resolver
ensp
ENSMUSP00000170273
resolver
ensp
ENSMUSP00000170275
resolver
ensp
ENSMUSP00000170276
resolver
ensp
ENSMUSP00000170277
resolver
ensp
ENSMUSP00000170279
resolver
ensp
ENSMUSP00000170280
resolver
ensp
ENSMUSP00000170281
resolver
ensp
ENSMUSP00000170287
resolver
ensp
ENSMUSP00000170288
resolver
ensp
ENSMUSP00000170292
resolver
ensp
ENSMUSP00000170293
resolver
ensp
ENSMUSP00000170296
resolver
ensp
ENSMUSP00000170302
resolver
ensp
ENSMUSP00000170307
resolver
ensp
ENSMUSP00000170317
resolver
ensp
ENSMUSP00000326989
resolver
enst
ENSMUST00000066473
resolver
enst
ENSMUST00000099723
resolver
enst
ENSMUST00000099725
resolver
enst
ENSMUST00000111370
resolver
genesymbol
Madd
resolver
genesymbol_syn
Kiaa0358
resolver
uniprot
A0A0R4J1F4
resolver
uniprot
A2AGR0
resolver
uniprot
E9QKN1
resolver
uniprot
E9QN47
resolver
uniprot
Q3TQK3
resolver
uniprot
Q6P4I6
resolver
uniprot
Q80W52
resolver
uniprot
Q80WL3
resolver
uniprot
Q80WL4
resolver
uniprot
Q80WL5
resolver
uniprot
Q80WL6
resolver
uniprot
Q80WL7
resolver
uniprot
Q80WL8
resolver
uniprot
Q80WL9
resolver
uniprot
Q80WM0
resolver
uniprot
Q80WM1
resolver
uniprot
Q80WM2
resolver
uniprot
Q8CBC1
resolver
uniprot_entry
A0A0R4J1F4_MOUSE
resolver
uniprot_entry
A2AGR0_MOUSE
resolver
uniprot_entry
E9QN47_MOUSE
resolver
uniprot_entry
MADD_MOUSE
resolver
uniprot_sec
E9QKN1
resolver
uniprot_sec
Q3TQK3
resolver
uniprot_sec
Q6P4I6
resolver
uniprot_sec
Q80W52
resolver
uniprot_sec
Q80WL3
resolver
uniprot_sec
Q80WL4
resolver
uniprot_sec
Q80WL5
resolver
uniprot_sec
Q80WL6
resolver
uniprot_sec
Q80WL7
resolver
uniprot_sec
Q80WL8
resolver
uniprot_sec
Q80WL9
resolver
uniprot_sec
Q80WM0
resolver
uniprot_sec
Q80WM1
resolver
uniprot_sec
Q80WM2
resolver
uniprot_sec
Q8CBC1
resolver
amino_acid_sequence
MVQKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRMPKEKVEGGAGPRGKEGAHTSGASEEAATGSSESGSTLQPPSADSTPDINQSPWGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLQDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQQALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIHNNTFDPALIGDKPKWYAHQLQPIHYRVYDGNSQLAEALSVPPERDSDSDPTEDSGSDSQDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQPQKEGEEPGPDSENSQENPPLRSSSSTTASSSPSTVVHSAHSEAADSTEMGDKATAGISKPLPPVPPSICKSTVDRRQTETGEGSVCQRTYDNPYFEPQYGFPPEEDEEEQGESYTPRFSQHVSGSRAQKLLRPNSLKLASDSDAESDSRASSPNSTVSNNSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKTTPFPSLKVFGLNTLMEIVTEAGPGSGEGNRRALVDQKSSVIKHSPTVKREPSSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRAVQSEDDARQDVIQDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTENVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFVASVELWNKHQEVKKQKALEKQRPEGIKPVFDLGETEEKKSQMSADSGVSLTSASQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGADSDLSSNAGDGPGGEGSAHLASSRATLSDSEIETNSATSAIFGKAHSLKPKEKPAGSPIRSSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSLSKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQVNEVLDQLNSLNGRDLSIRSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHNQFLKLKKW
uniprot
proteins
function
FUNCTION: Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:11359932, PubMed:18559336). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (PubMed:11359932, PubMed:12388783, PubMed:18849981). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (PubMed:12388783). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (PubMed:18849981). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (By similarity). May link TNFRSF1A with MAP kinase activation (By similarity). May be involved in the regulation of TNFA-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q8WXG6, ECO:0000269|PubMed:11359932, ECO:0000269|PubMed:12388783, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:18849981}.
uniprot
proteins
mass_dalton
175180
uniprot
proteins
protein_family
MADD family
uniprot
proteins
pubmed
11359932
uniprot
proteins
pubmed
12388783
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
18559336
uniprot
proteins
pubmed
18849981
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1577
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8WXG6}. Cytoplasm {ECO:0000250|UniProtKB:Q8WXG6}. Cell projection, axon {ECO:0000269|PubMed:18849981}.
uniprot
proteins