Kbtbd8
entrez
243574
canonical
uniprot
Q3UQV5
canonical
ensembl
ENSMUSG00000030031
resolver
ensp
ENSMUSP00000032107
resolver
ensp
ENSMUSP00000113739
resolver
genesymbol
Kbtbd8
resolver
genesymbol_syn
Kiaa1842
resolver
uniprot
Q3TJB2
resolver
uniprot
Q5M7B2
resolver
uniprot
Q8CH97
resolver
uniprot_entry
KBTB8_MOUSE
resolver
uniprot_sec
Q3TJB2
resolver
uniprot_sec
Q5M7B2
resolver
uniprot_sec
Q8CH97
resolver
amino_acid_sequence
MAASADLSKSSPTPNGIPSSDTANDTMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMDLVLNYAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQSEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIVKSCGEPSNTSGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWMTVCAMPVAMEFHNAVEHKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRVFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRATQVTVEEHIFRTSRKNSLYQYDDIADQWMKVYETPDRLWDLGRHFECAVAKLYPQCLQKVL
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. {ECO:0000250|UniProtKB:Q8NFY9}.
uniprot
proteins
mass_dalton
68660
uniprot
proteins
protein_family
KBTBD8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
26399832
uniprot
proteins
sequence_length
599
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8NFY9}. Golgi apparatus {ECO:0000250|UniProtKB:Q8NFY9}. Note=Translocates to the spindle apparatus during mitosis. {ECO:0000250|UniProtKB:Q8NFY9}.
uniprot
proteins