RHOT2
entrez
89941
canonical
uniprot
Q8IXI1
canonical
ensembl
ENSG00000140983
resolver
ensp
ENSP00000321971
resolver
ensp
ENSP00000513180
resolver
ensp
ENSP00000597779
resolver
ensp
ENSP00000649461
resolver
enst
ENST00000697194
resolver
genesymbol
RHOT2
resolver
genesymbol_syn
ARHT2
resolver
genesymbol_syn
C16orf39
resolver
hgnc
HGNC:21169
resolver
uniprot
A0A8V8TM48
resolver
uniprot
A2IDC2
resolver
uniprot
Q8NF53
resolver
uniprot
Q96C13
resolver
uniprot
Q96S17
resolver
uniprot
Q9BT60
resolver
uniprot
Q9H7M8
resolver
uniprot_entry
A0A8V8TM48_HUMAN
resolver
uniprot_entry
MIRO2_HUMAN
resolver
uniprot_sec
A2IDC2
resolver
uniprot_sec
Q8NF53
resolver
uniprot_sec
Q96C13
resolver
uniprot_sec
Q96S17
resolver
uniprot_sec
Q9BT60
resolver
uniprot_sec
Q9H7M8
resolver
amino_acid_sequence
MRRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPPRAEEITIPADVTPEKVPTHIVDYSEAEQTDEELREEIHKANVVCVVYDVSEEATIEKIRTKWIPLVNGGTTQGPRVPIILVGNKSDLRSGSSMEAVLPIMSQFPEIETCVECSAKNLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDLDQALSDEELNAFQKSCFGHPLAPQALEDVKTVVCRNVAGGVREDRLTLDGFLFLNTLFIQRGRHETTWTILRRFGYSDALELTADYLSPLIHVPPGCSTELNHLGYQFVQRVFEKHDQDRDGALSPVELQSLFSVFPAAPWGPELPRTVRTEAGRLPLHGYLCQWTLVTYLDVRSCLGHLGYLGYPTLCEQDQAHAITVTREKRLDQEKGQTQRSVLLCKVVGARGVGKSAFLQAFLGRGLGHQDTREQPPGYAIDTVQVNGQEKYLILCEVGTDGLLATSLDATCDVACLMFDGSDPKSFAHCASVYKHHYMDGQTPCLFVSSKADLPEGVAVSGPSPAEFCRKHRLPAPVPFSCAGPAEPSTTIFTQLATMAAFPHLVHAELHPSSFWLRGLLGVVGAAVAAVLSFSLYRVLVKSQ
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657). Can hydrolyze GTP (By similarity). Can hydrolyze ATP and UTP (PubMed:30513825). {ECO:0000250|UniProtKB:Q8IXI2, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:30513825}.
uniprot
proteins
mass_dalton
68118
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="A->V: Causes constitutive activation inducing an aggregation of the mitochondrial network."; /evidence="ECO:0000269|PubMed:14521508, ECO:0000269|PubMed:16630562"; MUTAGEN 18; /note="T->N: Induces an aggregation of the mitochondrial network."; /evidence="ECO:0000269|PubMed:16630562
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by PRKN in a PINK1-dependent manner, leading to its degradation. {ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:27605430}.
uniprot
proteins
protein_family
Mitochondrial Rho GTPase family
uniprot
proteins
pubmed
11157797
uniprot
proteins
pubmed
12482879
uniprot
proteins
pubmed
14521508
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15218247
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16630562
uniprot
proteins
pubmed
19528298
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22396657
uniprot
proteins
pubmed
24995978
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27605430
uniprot
proteins
pubmed
30513825
uniprot
proteins
sequence_length
618
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}; Single-pass type IV membrane protein {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}. Note=Colocalizes with MGARP and RHOT2 at the mitochondria.
uniprot
proteins
transmembrane_region
TRANSMEM 593..615; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins