Il27ra
entrez
50931
canonical
uniprot
O70394
canonical
ensembl
ENSMUSG00000005465
resolver
ensp
ENSMUSP00000005601
resolver
ensp
ENSMUSP00000179958
resolver
ensp
ENSMUSP00000179963
resolver
enst
ENSMUST00000005601
resolver
genesymbol
Il27ra
resolver
genesymbol_syn
Tccr
resolver
genesymbol_syn
Wsx1
resolver
uniprot
E9QNY4
resolver
uniprot
Q3UZN3
resolver
uniprot_entry
I27RA_MOUSE
resolver
uniprot_entry
Q3UZN3_MOUSE
resolver
uniprot_sec
E9QNY4
resolver
amino_acid_sequence
MNRLRVARLTPLELLLSLMSLLLGTRPHGSPGPLQCYSVGPLGILNCSWEPLGDLETPPVLYHQSQKYHPNRVWEVKVPSKQSWVTIPREQFTMADKLLIWGTQKGRPLWSSVSVNLETQMKPDTPQIFSQVDISEEATLEATVQWAPPVWPPQKVLICQFRYKECQAETWTRLEPQLKTDGLTPVEMQNLEPGTCYQVSGRCQVENGYPWGEWSSPLSFQTPFLDPEDVWVSGTVCETSGKRAALLVWKDPRPCVQVTYTVWFGAGDITTTQEEVPCCKSPVPAWMEWAVVSPGNSTSWVPPTNLSLVCLAPESAPCDVGVSSADGSPGIKVTWKQGTRKPLEYVVDWAQDGDSLDKLNWTRLPPGNLSTLLPGEFKGGVPYRITVTAVYSGGLAAAPSVWGFREELVPLAGPAVWRLPDDPPGTPVVAWGEVPRHQLRGQATHYTFCIQSRGLSTVCRNVSSQTQTATLPNLHLGSFKLWVTVSTVAGQGPPGPNLSLHLPDNRIRWKALPWFLSLWGLLLMGCGLSLASTRCLQARCLHWRHKLLPQWIWERVPDPANSNSGQPYIKEVSLPQPPKDGPILEVEEVELQPVVESPKASAPIYSGYEKHFLPTPEELGLLV
uniprot
proteins
function
FUNCTION: Signal-transducing subunit for an heterodimeric cytokine composed of IL27/p28 and a soluble receptor EBI3. Heterodimerizes with IL6ST/GP130 to mediate signal transduction in response to the heterodimeric cytokine IL27/p28-EBI3. This signaling system acts through STAT3 and STAT1. Also acts as a signaling receptor as part of the humanin receptor complex; binding of MT-RNR2/humanin (HN) activates the intracellular JAK-STAT3 signaling pathway leading to neuroprotection (By similarity). Involved in the regulation of Th1-type immune responses (PubMed:11057672). Also appears to be involved in innate defense mechanisms (By similarity). {ECO:0000250|UniProtKB:Q6UWB1, ECO:0000269|PubMed:11057672}.
uniprot
proteins
mass_dalton
69093
uniprot
proteins
protein_family
Type 2 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
11057672
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9600072
uniprot
proteins
sequence_length
623
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 511..531; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins