Smad5
entrez
59328
canonical
uniprot
Q9R1V3
canonical
ensembl
ENSRNOG00000022870
resolver
ensembl
ENSRNOG00055024650
resolver
ensembl
ENSRNOG00060019755
resolver
ensembl
ENSRNOG00065024555
resolver
ensp
ENSRNOP00000016704
resolver
ensp
ENSRNOP00055034721
resolver
ensp
ENSRNOP00060028141
resolver
ensp
ENSRNOP00065034538
resolver
enst
ENSRNOT00000016704
resolver
enst
ENSRNOT00055042516
resolver
enst
ENSRNOT00060034308
resolver
enst
ENSRNOT00065042234
resolver
genesymbol
Smad5
resolver
genesymbol_syn
Madh5
resolver
uniprot
B1WBR0
resolver
uniprot_entry
B1WBR0_RAT
resolver
uniprot_entry
SMAD5_RAT
resolver
amino_acid_sequence
MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNSTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQPMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPANNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS
uniprot
proteins
function
FUNCTION: Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis. Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network. Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes. Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis. {ECO:0000250|UniProtKB:Q99717}.
uniprot
proteins
mass_dalton
52215
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase. {ECO:0000250|UniProtKB:Q99717}.; PTM: Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1. {ECO:0000250|UniProtKB:Q99717}.
uniprot
proteins
protein_family
Dwarfin/SMAD family
uniprot
proteins
pubmed
11527422
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99717}. Nucleus {ECO:0000250|UniProtKB:Q99717}. Mitochondrion {ECO:0000250|UniProtKB:Q99717}. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. {ECO:0000250|UniProtKB:Q99717}.
uniprot
proteins