Bbc3
entrez
170770
canonical
uniprot
Q99ML1
canonical
ensembl
ENSMUSG00000002083
resolver
ensp
ENSMUSP00000002152
resolver
ensp
ENSMUSP00000185437
resolver
ensp
ENSMUSP00000185440
resolver
ensp
ENSMUSP00000185443
resolver
ensp
ENSMUSP00000185444
resolver
ensp
ENSMUSP00000185446
resolver
enst
ENSMUST00000002152
resolver
genesymbol
Bbc3
resolver
genesymbol_syn
Puma
resolver
uniprot
B2RVL4
resolver
uniprot_entry
B2RVL4_MOUSE
resolver
uniprot_entry
BBC3_MOUSE
resolver
amino_acid_sequence
MARARQEGSSPEPVEGLARDSPRPFPLGRLMPSAVSCSLCEPGLPAAPAAPALLPAAYLCAPTAPPAVTAALGGPRWPGGHRSRPRGPRPDGPQPSLSPAQQHLESPVPSAPEALAGGPTQAAPGVRVEEEEWAREIGAQLRRMADDLNAQYERRRQEEQHRHRPSPWRVMYNLFMGLLPLPRDPGAPEMEPN
uniprot
proteins
function
FUNCTION: Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (By similarity). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (By similarity). Regulates ER stress-induced neuronal apoptosis (PubMed:21159964, PubMed:22761832). {ECO:0000250|UniProtKB:Q9BXH1, ECO:0000269|PubMed:21159964, ECO:0000269|PubMed:22761832}.
uniprot
proteins
mass_dalton
20749
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
11463391
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18462686
uniprot
proteins
pubmed
18589438
uniprot
proteins
pubmed
21159964
uniprot
proteins
pubmed
22761832
uniprot
proteins
sequence_length
193
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release. {ECO:0000250}.
uniprot
proteins