Lsr
entrez
54135
canonical
uniprot
Q99KG5
canonical
ensembl
ENSMUSG00000001247
resolver
ensp
ENSMUSP00000001279
resolver
ensp
ENSMUSP00000096153
resolver
ensp
ENSMUSP00000103751
resolver
genesymbol
Lsr
resolver
genesymbol_syn
Ildr3
resolver
genesymbol_syn
Lisch7
resolver
uniprot
Q3TJE7
resolver
uniprot
Q3UIQ9
resolver
uniprot
Q61148
resolver
uniprot
Q61149
resolver
uniprot
Q6U816
resolver
uniprot_entry
LSR_MOUSE
resolver
uniprot_sec
Q3TJE7
resolver
uniprot_sec
Q3UIQ9
resolver
uniprot_sec
Q61148
resolver
uniprot_sec
Q61149
resolver
uniprot_sec
Q6U816
resolver
amino_acid_sequence
MAPAASACAGAPGSHPATTIFVCLFLIIYCPDRASAIQVTVPDPYHVVILFQPVTLHCTYQMSNTLTAPIVIWKYKSFCRDRVADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFEQTAWGDSGVYYCSVVSAQDLDGNNEAYAELIVLGRTSEAPELLPGFRAGPLEDWLFVVVVCLASLLFFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSIYTHLSPAKTPPPPPAMIPMRPPYGYPGDFDRTSSVGGHSSQVPLLREVDGSVSSEVRSGYRIQANQQDDSMRVLYYMEKELANFDPSRPGPPNGRVERAMSEVTSLHEDDWRSRPSRAPALTPIRDEEWNRHSPRSPRTWEQEPLQEQPRGGWGSGRPRARSVDALDDINRPGSTESGRSSPPSSGRRGRAYAPPRSRSRDDLYDPDDPRDLPHSRDPHYYDDLRSRDPRADPRSRQRSHDPRDAGFRSRDPQYDGRLLEEALKKKGAGERRRVYREEEEEEEEGHYPPAPPPYSETDSQASRERRMKKNLALSRESLVV
uniprot
proteins
function
FUNCTION: Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (PubMed:15265030). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (PubMed:21245199, PubMed:23239027). {ECO:0000269|PubMed:15265030, ECO:0000269|PubMed:21245199, ECO:0000269|PubMed:23239027}.
uniprot
proteins
mass_dalton
66108
uniprot
proteins
mutagenesis
MUTAGEN 308; /note="S->A: Decreased phosphorylation levels."; /evidence="ECO:0000269|PubMed:24889144
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-308 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions. {ECO:0000269|PubMed:24889144}.; PTM: Polyubiquitinated at Lys-583 via 'Lys-63'-linked ubiquitin chains; deubiquitinated by USP53. {ECO:0000250|UniProtKB:Q86X29}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
LISCH7 family
uniprot
proteins
pubmed
15265030
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21245199
uniprot
proteins
pubmed
23239027
uniprot
proteins
pubmed
24889144
uniprot
proteins
pubmed
30250217
uniprot
proteins
sequence_length
594
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21245199}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:21245199, ECO:0000269|PubMed:23239027, ECO:0000269|PubMed:24889144}. Note=Located at tricellular contacts. {ECO:0000269|PubMed:21245199, ECO:0000269|PubMed:23239027, ECO:0000269|PubMed:24889144}.
uniprot
proteins
transmembrane_region
TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins