TMEM117
entrez
84216
canonical
uniprot
Q9H0C3
canonical
ensembl
ENSG00000139173
resolver
ensp
ENSP00000266534
resolver
ensp
ENSP00000448595
resolver
ensp
ENSP00000638434
resolver
ensp
ENSP00000638435
resolver
enst
ENST00000266534
resolver
enst
ENST00000551577
resolver
enst
ENST00000968375
resolver
enst
ENST00000968376
resolver
genesymbol
TMEM117
resolver
hgnc
HGNC:25308
resolver
uniprot
F8VS00
resolver
uniprot
Q05C15
resolver
uniprot_entry
F8VS00_HUMAN
resolver
uniprot_entry
Q05C15_HUMAN
resolver
uniprot_entry
TM117_HUMAN
resolver
amino_acid_sequence
MGKDFRYYFQHPWSRMIVAYLVIFFNFLIFAEDPVSHSQTEANVIVVGNCFSFVTNKYPRGVGWRILKVLLWLLAILTGLIAGKFLFHQRLFGQLLRLKMFREDHGSWMTMFFSTILFLFIFSHIYNTILLMDGNMGAYIITDYMGIRNESFMKLAAVGTWMGDFVTAWMVTDMMLQDKPYPDWGKSARAFWKKGNVRITLFWTVLFTLTSVVVLVITTDWISWDKLNRGFLPSDEVSRAFLASFILVFDLLIVMQDWEFPHFMGDVDVNLPGLHTPHMQFKIPFFQKIFKEEYRIHITGKWFNYGIIFLVLILDLNMWKNQIFYKPHEYGQYIGPGQKIYTVKDSESLKDLNRTKLSWEWRSNHTNPRTNKTYVEGDMFLHSRFIGASLDVKCLAFVPSLIAFVWFGFFIWFFGRFLKNEPRMENQDKTYTRMKRKSPSEHSKDMGITRENTQASVEDPLNDPSLVCIRSDFNEIVYKSSHLTSENLSSQLNESTSATEADQDPTTSKSTPTN
uniprot
proteins
function
FUNCTION: Involved in endoplasmic reticulum (ER) stress-induced cell death pathway. {ECO:0000269|PubMed:28285135}.
uniprot
proteins
mass_dalton
60185
uniprot
proteins
mutagenesis
MUTAGEN 353; /note="N->A: Reduced N-glycosylation. Loss of N-glycosylation; when associated with A-371."; /evidence="ECO:0000269|PubMed:27391701"; MUTAGEN 371; /note="N->A: Reduced N-glycosylation. Loss of N-glycosylation; when associated with A-353."; /evidence="ECO:0000269|PubMed:27391701
uniprot
proteins
protein_family
TMEM117 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
27391701
uniprot
proteins
pubmed
28285135
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27391701}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 66..86; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 111..131; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 199..219; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 240..260; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 296..316; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 395..415; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins