BHLHB2
entrez
8553
canonical
uniprot
O14503
canonical
ensembl
ENSG00000134107
resolver
ensp
ENSP00000256495
resolver
ensp
ENSP00000601129
resolver
enst
ENST00000256495
resolver
enst
ENST00000931070
resolver
genesymbol
BHLHB2
resolver
genesymbol
BHLHE40
resolver
genesymbol_syn
BHLHB2
resolver
genesymbol_syn
DEC1
resolver
genesymbol_syn
SHARP2
resolver
genesymbol_syn
STRA13
resolver
hgnc
HGNC:1046
resolver
uniprot
A0A024R2D0
resolver
uniprot
Q6IB83
resolver
uniprot
Q96TD3
resolver
uniprot_entry
BHE40_HUMAN
resolver
uniprot_entry
Q6IB83_HUMAN
resolver
uniprot_sec
A0A024R2D0
resolver
uniprot_sec
Q96TD3
resolver
amino_acid_sequence
MERIPSAQPPPACLPKAPGLEHGDLPGMYPAHMYQVYKSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTKKNRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAAALSSFMNPDKISAPLLMPQRLPSPLPAHPSVDSSVLLQALKPIPPLNLETKD
uniprot
proteins
function
FUNCTION: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:12397359, PubMed:18411297). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop) (PubMed:14672706). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2 (PubMed:15193144). Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1|BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:15560782). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2 (PubMed:14672706). Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity (PubMed:19786558). May be involved in the regulation of chondrocyte differentiation via the cAMP pathway (PubMed:19786558). Represses the transcription of NR0B2 and attenuates the transactivation of NR0B2 by the CLOCK-BMAL1 complex (PubMed:28797635). Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (PubMed:30012868). {ECO:0000269|PubMed:12397359, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:15193144, ECO:0000269|PubMed:15560782, ECO:0000269|PubMed:18411297, ECO:0000269|PubMed:19786558, ECO:0000269|PubMed:28797635, ECO:0000269|PubMed:30012868}.
uniprot
proteins
mass_dalton
45510
uniprot
proteins
mutagenesis
MUTAGEN 56; /note="P->A: No loss of repressor activity against NR0B2."; /evidence="ECO:0000269|PubMed:28797635"; MUTAGEN 57; /note="H->A: No effect on its interaction with BMAL1 or its repressor activity against the CLOCK-BMAL1 heterodimer. Significant reduction in E-box binding."; /evidence="ECO:0000269|PubMed:15560782"; MUTAGEN 58; /note="R->A: Loss of repressor activity against NR0B2."; /evidence="ECO:0000269|PubMed:28797635"; MUTAGEN 65; /note="R->A: Loss of interaction with BMAL1 and E-box binding. Significant reduction in its repressor activity against the CLOCK-BMAL1 heterodimer."; /evidence="ECO:0000269|PubMed:15560782"; MUTAGEN 78..79; /note="LL->AA: Abolishes RXRA repression."; /evidence="ECO:0000269|PubMed:19786558"; MUTAGEN 159; /note="K->R: Partial loss of sumoylation. Complete loss of sumoylation; when associated with R-279."; /evidence="ECO:0000269|PubMed:21829689"; MUTAGEN 279; /note="K->R: Partial loss of sumoylation. Complete loss of sumoylation; when associated with R-159."; /evidence="ECO:0000269|PubMed:21829689
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; which may lead to proteasomal degradation. {ECO:0000269|PubMed:11278694}.; PTM: Sumoylation inhibits its ubiquitination and promotes its negative regulation of the CLOCK-BMAL1 heterodimer transcriptional activator activity. {ECO:0000269|PubMed:11278694, ECO:0000269|PubMed:21829689}.
uniprot
proteins
pubmed
11226878
uniprot
proteins
pubmed
11278694
uniprot
proteins
pubmed
12397359
uniprot
proteins
pubmed
14672706
uniprot
proteins
pubmed
15193144
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15560782
uniprot
proteins
pubmed
18411297
uniprot
proteins
pubmed
19786558
uniprot
proteins
pubmed
21829689
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28797635
uniprot
proteins
pubmed
30012868
uniprot
proteins
pubmed
9240428
uniprot
proteins
sequence_length
412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21829689}. Nucleus {ECO:0000269|PubMed:11278694, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:28797635}. Note=Predominantly localized in the nucleus (PubMed:11278694). {ECO:0000269|PubMed:11278694}.
uniprot
proteins