Eng
entrez
13805
canonical
uniprot
Q63961
canonical
ensembl
ENSMUSG00000026814
resolver
ensp
ENSMUSP00000009705
resolver
ensp
ENSMUSP00000108897
resolver
ensp
ENSMUSP00000130585
resolver
enst
ENSMUST00000009705
resolver
enst
ENSMUST00000113272
resolver
enst
ENSMUST00000167841
resolver
genesymbol
Eng
resolver
genesymbol_syn
Edg
resolver
uniprot
A0ACM8Q8J8
resolver
uniprot
E9Q5I7
resolver
uniprot
F7A1B4
resolver
uniprot
Q3UAM9
resolver
uniprot
Q61520
resolver
uniprot
Q8K100
resolver
uniprot_entry
A0ACM8Q8J8_MOUSE
resolver
uniprot_entry
EGLN_MOUSE
resolver
uniprot_entry
F7A1B4_MOUSE
resolver
uniprot_entry
Q3UAM9_MOUSE
resolver
uniprot_sec
E9Q5I7
resolver
uniprot_sec
Q61520
resolver
uniprot_sec
Q8K100
resolver
amino_acid_sequence
MDRGVLPLPITLLFVIYSFVPTTGLAERVGCDLQPVDPTRGEVTFTTSQVSEGCVAQAANAVREVHVLFLDFPGMLSHLELTLQASKQNGTETQEVFLVLVSNKNVFVKFQAPEIPLHLAYDSSLVIFQGQPRVNITVLPSLTSRKQILDWAATKGAITSIAALDDPQSIVLQLGQDPKAPFLCLPEAHKDMGATLEWQPRAQTPVQSCRLEGVSGHKEAYILRILPGSEAGPRTVTVMMELSCTSGDAILILHGPPYVSWFIDINHSMQILTTGEYSVKIFPGSKVKGVELPDTPQGLIAEARKLNASIVTSFVELPLVSNVSLRASSCGGVFQTTPAPVVTTPPKDTCSPVLLMSLIQPKCGNQVMTLALNKKHVQTLQCTITGLTFWDSSCQAEDTDDHLVLSSAYSSCGMKVTAHVVSNEVIISFPSGSPPLRKKVQCIDMDSLSFQLGLYLSPHFLQASNTIELGQQAFVQVSVSPLTSEVTVQLDSCHLDLGPEGDMVELIQSRTAKGSCVTLLSPSPEGDPRFSFLLRVYMVPTPTAGTLSCNLALRPSTLSQEVYKTVSMRLNIVSPDLSGKGLVLPSVLGITFGAFLIGALLTAALWYIYSHTRGPSKREPVVAVAAPASSESSSTNHSIGSTQSTPCSTSSMA
uniprot
proteins
function
FUNCTION: Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:10625534). Required for normal structure and integrity of adult vasculature (By similarity). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (PubMed:10625534). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (PubMed:28530658). May play a role in the binding of endothelial cells to integrins. Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (By similarity). {ECO:0000250|UniProtKB:P17813, ECO:0000269|PubMed:10625534, ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:23300529, ECO:0000269|PubMed:28530658}.
uniprot
proteins
mass_dalton
70021
uniprot
proteins
pubmed
10625534
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17540773
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20042635
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21737454
uniprot
proteins
pubmed
23300529
uniprot
proteins
pubmed
28530658
uniprot
proteins
pubmed
8125301
uniprot
proteins
pubmed
8194490
uniprot
proteins
sequence_length
653
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8125301}; Single-pass type I membrane protein {ECO:0000305|PubMed:8125301}.
uniprot
proteins
transmembrane_region
TRANSMEM 582..606; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins