MCF2L
entrez
23263
canonical
uniprot
O15068
canonical
ensembl
ENSG00000126217
resolver
ensp
ENSP00000364747
resolver
ensp
ENSP00000364754
resolver
ensp
ENSP00000364758
resolver
ensp
ENSP00000380225
resolver
ensp
ENSP00000392953
resolver
ensp
ENSP00000397285
resolver
ensp
ENSP00000404422
resolver
ensp
ENSP00000440374
resolver
enst
ENST00000453297
resolver
genesymbol
MCF2L
resolver
genesymbol_syn
KIAA0362
resolver
genesymbol_syn
OST
resolver
hgnc
HGNC:14576
resolver
uniprot
A2A2X1
resolver
uniprot
A2A2X2
resolver
uniprot
A2A3G6
resolver
uniprot
A2A3G8
resolver
uniprot
B4DHD6
resolver
uniprot
B4DIL6
resolver
uniprot
E9PDN8
resolver
uniprot
H0Y4M6
resolver
uniprot
Q5JU56
resolver
uniprot
Q5VXT1
resolver
uniprot
Q6ZWD4
resolver
uniprot
Q765G8
resolver
uniprot
Q765G9
resolver
uniprot
Q8N679
resolver
uniprot_entry
H0Y4M6_HUMAN
resolver
uniprot_entry
MCF2L_HUMAN
resolver
uniprot_sec
A2A2X1
resolver
uniprot_sec
A2A2X2
resolver
uniprot_sec
A2A3G6
resolver
uniprot_sec
A2A3G8
resolver
uniprot_sec
B4DHD6
resolver
uniprot_sec
B4DIL6
resolver
uniprot_sec
E9PDN8
resolver
uniprot_sec
Q5JU56
resolver
uniprot_sec
Q5VXT1
resolver
uniprot_sec
Q6ZWD4
resolver
uniprot_sec
Q765G8
resolver
uniprot_sec
Q765G9
resolver
uniprot_sec
Q8N679
resolver
amino_acid_sequence
MFDCWRFILCKRPGSNSYSSPQRPNEAKKEETDHQIDVSDVIRLVQDTPEATAMATDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCLSSSGKAHVPRAHP
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669). {ECO:0000250|UniProtKB:Q63406, ECO:0000269|PubMed:15157669}.; FUNCTION: [Isoform 3]: Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669). {ECO:0000269|PubMed:15157669}.
uniprot
proteins
mass_dalton
128109
uniprot
proteins
protein_family
MCF2 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15157669
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9205841
uniprot
proteins
sequence_length
1137
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:15157669}. Cell membrane {ECO:0000269|PubMed:15157669}; Peripheral membrane protein {ECO:0000269|PubMed:15157669}; Cytoplasmic side {ECO:0000269|PubMed:15157669}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:15157669}. Endomembrane system {ECO:0000269|PubMed:15157669}. Note=Interaction with membranes enriched in phosphoinositides is mediated by the CRAL-TRIO domain. {ECO:0000269|PubMed:15157669}.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q64096}. Cell membrane {ECO:0000250|UniProtKB:Q64096}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64096}; Cytoplasmic side {ECO:0000250|UniProtKB:Q64096}.
uniprot
proteins