DDX1
entrez
1653
canonical
uniprot
Q92499
canonical
ensembl
ENSG00000079785
resolver
ensp
ENSP00000233084
resolver
genesymbol
DDX1
resolver
hgnc
HGNC:2734
resolver
uniprot
A3RJH1
resolver
uniprot
B4DME8
resolver
uniprot
B4DPN6
resolver
uniprot_entry
A3RJH1_HUMAN
resolver
uniprot_entry
DDX1_HUMAN
resolver
uniprot_sec
B4DME8
resolver
uniprot_sec
B4DPN6
resolver
amino_acid_sequence
MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPVIQIVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWHGCRATKGLMKGKHYYEVSCHDQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDIDKGHVKFSKNGKDLGLAFEIPPHMKNQALFPACVLKNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGGSYKGHVDILAPTVQELAALEKEAQTSFLHLGYLPNQLFRTF
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. It is also an accessory subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. Cooperates with ZBTB8OS (also known as archease) for the guanylylation of RTCB, a key intermediate step in activation of the tRNA ligase (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}.
uniprot
proteins
mass_dalton
82432
uniprot
proteins
mutagenesis
MUTAGEN 52; /note="K->N: Abolishes ability to promote guanylylation of RTCB."; /evidence="ECO:0000269|PubMed:24870230"; MUTAGEN 371; /note="E->G: Inhibits the transcriptional activity of RELA and attenuates NF-kappa-B-mediated gene expression."; /evidence="ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:24870230"; MUTAGEN 371; /note="E->Q: Abolishes ability to promote guanylylation of RTCB."; /evidence="ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:24870230
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ATM kinase; phosphorylation is increased in response to ionizing radiation (IR). {ECO:0000269|PubMed:18710941}.
uniprot
proteins
protein_family
DDX1 subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
11598190
uniprot
proteins
pubmed
12183465
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15567440
uniprot
proteins
pubmed
18335541
uniprot
proteins
pubmed
18710941
uniprot
proteins
pubmed
19058135
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20573827
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21311021
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21589879
uniprot
proteins
pubmed
21933836
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24608264
uniprot
proteins
pubmed
24870230
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26030138
uniprot
proteins
pubmed
26323305
uniprot
proteins
pubmed
27105836
uniprot
proteins
pubmed
28040436
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
7689221
uniprot
proteins
sequence_length
740
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasmic granule. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q91VR5}. Mitochondrion {ECO:0000250|UniProtKB:Q91VR5}. Note=Localized with MBNL1, TIAL1 and YBX1 in stress granules upon stress. Localized with CSTF2 in cleavage bodies. Forms large aggregates called DDX1 bodies. Relocalized into multiple foci (IR-induced foci or IRIF) after IR treatment, a process that depends on the presence of chromosomal DNA and/or RNA-DNA duplexes. Relocalized at sites of DNA double-strand breaks (DSBs) in an ATM-dependent manner after IR treatment. Colocalized with RELA in the nucleus upon TNF induction. Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264). Colocalizes in the cytosol with DDX21, DHX36 and TICAM1. Colocalizes in the mitochondria with TICAM1 and poly(I:C) RNA ligand. The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) stimulation (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:24608264}.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20573827}. Note=(Microbial infection) Relocalized to the cytoplasm with a perinuclear staining pattern in avian infectious bronchitis virus (IBV)-infected cells (PubMed:20573827). Required for proper localization of HIV-1 Rev (PubMed:15567440). {ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:20573827}.
uniprot
proteins