Rarb
entrez
218772
canonical
uniprot
P22605
canonical
ensembl
ENSMUSG00000017491
resolver
ensp
ENSMUSP00000067694
resolver
genesymbol
Rarb
resolver
genesymbol_syn
Nr1b2
resolver
uniprot
P11417
resolver
uniprot
P22604
resolver
uniprot
Q6DFX0
resolver
uniprot_entry
Q6DFX0_MOUSE
resolver
uniprot_entry
RARB_MOUSE
resolver
uniprot_sec
P11417
resolver
uniprot_sec
P22604
resolver
amino_acid_sequence
MSTSSHACPVPAVRGHMTHYPAAPYPLLFPPVIRGLSLPPLHGLHGHPPPSGCSTPSPASVGQACQRTTGGSQFAASTKWTPSLNAAIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNIAEHSPSVSPSSVENSGVSQSPLLQ
uniprot
proteins
function
FUNCTION: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (PubMed:19389355). {ECO:0000250|UniProtKB:P10826, ECO:0000269|PubMed:19389355}.
uniprot
proteins
mass_dalton
53331
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
1313565
uniprot
proteins
pubmed
15528208
uniprot
proteins
pubmed
1663808
uniprot
proteins
pubmed
1846599
uniprot
proteins
pubmed
19389355
uniprot
proteins
pubmed
2544807
uniprot
proteins
pubmed
8383767
uniprot
proteins
sequence_length
482
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P10826}. Cytoplasm {ECO:0000250|UniProtKB:P10826}.
uniprot
proteins