Spin1
entrez
361217
canonical
uniprot
Q4V8J7
canonical
ensembl
ENSRNOG00000067284
resolver
ensembl
ENSRNOG00055004652
resolver
ensembl
ENSRNOG00055013696
resolver
ensembl
ENSRNOG00060001583
resolver
ensembl
ENSRNOG00060021785
resolver
ensembl
ENSRNOG00065010419
resolver
ensembl
ENSRNOG00065027241
resolver
ensp
ENSRNOP00000088564
resolver
ensp
ENSRNOP00000100473
resolver
ensp
ENSRNOP00055005554
resolver
ensp
ENSRNOP00055019128
resolver
ensp
ENSRNOP00060001555
resolver
ensp
ENSRNOP00060031126
resolver
ensp
ENSRNOP00065012902
resolver
ensp
ENSRNOP00065038544
resolver
enst
ENSRNOT00000095885
resolver
enst
ENSRNOT00055007396
resolver
enst
ENSRNOT00055023519
resolver
enst
ENSRNOT00060002386
resolver
enst
ENSRNOT00060037735
resolver
enst
ENSRNOT00065016861
resolver
enst
ENSRNOT00065046967
resolver
genesymbol
Spin1
resolver
genesymbol_syn
Spin
resolver
uniprot_entry
SPIN1_RAT
resolver
amino_acid_sequence
MKTPFGKTPGQRSRADAGHAGVSANMMKKRTSHKKHRTSVGPSKPVSQPRRNIVGCRIQHGWREGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDDRVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS
uniprot
proteins
function
FUNCTION: Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and 'Lys-9' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis. Plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation (By similarity). Also recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2 (By similarity). Overexpression induces metaphase arrest and chromosomal instability (By similarity). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (By similarity). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (By similarity). {ECO:0000250|UniProtKB:Q61142, ECO:0000250|UniProtKB:Q9Y657}.
uniprot
proteins
mass_dalton
29629
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during oocyte meiotic maturation. {ECO:0000250|UniProtKB:Q61142}.
uniprot
proteins
protein_family
SPIN/STSY family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y657}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9Y657}.
uniprot
proteins