Kcnn1
entrez
84036
canonical
uniprot
Q9EQR3
canonical
ensembl
ENSMUSG00000002908
resolver
ensp
ENSMUSP00000105705
resolver
ensp
ENSMUSP00000148544
resolver
ensp
ENSMUSP00000148705
resolver
ensp
ENSMUSP00000215390
resolver
enst
ENSMUST00000110078
resolver
enst
ENSMUST00000212509
resolver
enst
ENSMUST00000212611
resolver
genesymbol
Kcnn1
resolver
genesymbol_syn
Sk1
resolver
uniprot
A0A140T8Q8
resolver
uniprot
A0A1D5RMB2
resolver
uniprot
Q5CZY7
resolver
uniprot
Q6JXY1
resolver
uniprot
Q99JA9
resolver
uniprot_entry
A0A140T8Q8_MOUSE
resolver
uniprot_entry
A0A1D5RMB2_MOUSE
resolver
uniprot_entry
KCNN1_MOUSE
resolver
uniprot_sec
Q5CZY7
resolver
uniprot_sec
Q6JXY1
resolver
uniprot_sec
Q99JA9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by bee venom neurotoxin apamin. Inhibited by d-tubocurarine and tetraethylammonium (TEA). {ECO:0000250|UniProtKB:Q92952}.
uniprot
proteins
amino_acid_sequence
MSSHSHNGSVGQPLGSGPGFLGWEPVDPEAGRPLQPTQGPGLQMVAKGQPVRLSPGGSRGHPQEQEEEEEEEEEEDKTGSGKPPTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQLFLVDNGADDWRIAMTWERVSLISLELVVCAIHPVPGHYRFTWTARLAFSLVPSAAEADLDVLLSIPMFLRLYLLARVMLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSVSSWIVAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQGRVRKHQRKFLQAIHQAQKLRSVKIEQGKVNDQANTLAELAKAQSIAYEVVSELQAQQEELEARLAALESRLDVLGASLQALPGLIAQAICPLPPPWPGPGHLATATHSPQSHWLPTMGSDCG
uniprot
proteins
function
FUNCTION: Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:11267657, PubMed:11557517). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:11557517). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (By similarity). Activation is followed by membrane hyperpolarization (PubMed:11557517). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (Probable). {ECO:0000250|UniProtKB:Q92952, ECO:0000269|PubMed:11267657, ECO:0000269|PubMed:11557517, ECO:0000305|PubMed:11557517}.
uniprot
proteins
mass_dalton
59330
uniprot
proteins
protein_family
KCa2.1/KCNN1 subfamily
uniprot
proteins
protein_family
Potassium channel KCNN family
uniprot
proteins
pubmed
11267657
uniprot
proteins
pubmed
11557517
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16055520
uniprot
proteins
pubmed
20689065
uniprot
proteins
sequence_length
537
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:20689065}.
uniprot
proteins
transmembrane_region
TRANSMEM 108..128; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 137..157; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 176..196; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 274..294; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255
uniprot
proteins