EML4
entrez
27436
canonical
uniprot
Q9HC35
canonical
ensembl
ENSG00000143924
resolver
ensp
ENSP00000320663
resolver
ensp
ENSP00000384939
resolver
ensp
ENSP00000385059
resolver
ensp
ENSP00000591529
resolver
ensp
ENSP00000707071
resolver
enst
ENST00000401738
resolver
genesymbol
EML4
resolver
genesymbol_syn
C2orf2
resolver
genesymbol_syn
EMAPL4
resolver
hgnc
HGNC:1316
resolver
uniprot
A6H8Y6
resolver
uniprot
A6P4T4
resolver
uniprot
A6P4V4
resolver
uniprot
B2RBK3
resolver
uniprot
B2RTW7
resolver
uniprot
B5MBZ0
resolver
uniprot
B5MCW9
resolver
uniprot
Q3SWW0
resolver
uniprot
Q53R29
resolver
uniprot
Q53TW8
resolver
uniprot
Q6PJ45
resolver
uniprot
Q9NV40
resolver
uniprot_entry
B5MBZ0_HUMAN
resolver
uniprot_entry
EMAL4_HUMAN
resolver
uniprot_sec
A6H8Y6
resolver
uniprot_sec
A6P4T4
resolver
uniprot_sec
A6P4V4
resolver
uniprot_sec
B2RBK3
resolver
uniprot_sec
B2RTW7
resolver
uniprot_sec
B5MCW9
resolver
uniprot_sec
Q3SWW0
resolver
uniprot_sec
Q53R29
resolver
uniprot_sec
Q53TW8
resolver
uniprot_sec
Q6PJ45
resolver
uniprot_sec
Q9NV40
resolver
amino_acid_sequence
MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNEISKEQAKATLLEDQQDPSPSS
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving EML4 has been identified in a subset of patients with non-small-cell lung carcinoma. This aberration leads to the production of a fusion protein between the N-terminus of EML4 and the C-terminus of ALK. It is unclear whether the fusion protein is caused by a simple inversion within 2p (inv(2)(p21p23)) or whether the chromosome translocation involving 2p is more complex. When tested in a heterologous system, the fusion protein EML4-ALK possesses transforming activity that is dependent on ALK catalytic activity, possibly due to spontaneous dimerization mediated by the EML4 moiety, leading to ALK kinase activation. {ECO:0000269|PubMed:17625570}.
uniprot
proteins
function
FUNCTION: Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}.
uniprot
proteins
mass_dalton
108916
uniprot
proteins
mutagenesis
MUTAGEN 144; /note="S->A: Phosphorylation-deficient mutant which shows increased localization to microtubules during mitosis, increased microtubule stability and impaired chromosome congression; when associated with A-146."; /evidence="ECO:0000269|PubMed:31409757"; MUTAGEN 144; /note="S->D: Phosphomimetic mutant which shows reduced localization to microtubules during interphase; when associated with D-146."; /evidence="ECO:0000269|PubMed:31409757"; MUTAGEN 146; /note="S->A: Phosphorylation-deficient mutant which shows increased localization to microtubules during mitosis, increased microtubule stability and impaired chromosome congression; when associated with A-144."; /evidence="ECO:0000269|PubMed:31409757"; MUTAGEN 146; /note="S->D: Phosphomimetic mutant which shows reduced localization to microtubules during interphase; when associated with D-144."; /evidence="ECO:0000269|PubMed:31409757
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during mitosis (PubMed:16890222). Phosphorylation at Ser-144 and Ser-146 promotes its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:31409757}.
uniprot
proteins
protein_family
WD repeat EMAP family
uniprot
proteins
pubmed
10995578
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16890222
uniprot
proteins
pubmed
17625570
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25740311
uniprot
proteins
pubmed
25789526
uniprot
proteins
pubmed
31409757
uniprot
proteins
sequence_length
981
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:31409757, ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16890222}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526}. Midbody {ECO:0000269|PubMed:25789526}. Note=Localizes to microtubules (MTs) during interphase with a significantly reduced affinity for MTs during mitosis. {ECO:0000269|PubMed:31409757}.
uniprot
proteins