Eif6
entrez
305506
canonical
uniprot
Q3KRD8
canonical
ensembl
ENSRNOG00000049497
resolver
ensembl
ENSRNOG00055024559
resolver
ensembl
ENSRNOG00060028303
resolver
ensembl
ENSRNOG00065028436
resolver
ensp
ENSRNOP00000080957
resolver
ensp
ENSRNOP00055034509
resolver
ensp
ENSRNOP00060041089
resolver
ensp
ENSRNOP00065040194
resolver
enst
ENSRNOT00055042277
resolver
enst
ENSRNOT00060049230
resolver
enst
ENSRNOT00065049009
resolver
genesymbol
Eif6
resolver
genesymbol_syn
Itgb4bp
resolver
uniprot_entry
IF6_RAT
resolver
amino_acid_sequence
MAVRASFENNCEVGCFAKLTNTYCLVAIGGSENFYSVFEGELSDTIPVVHASIAGCRIIGRMCVGNRHGLLVPNNTTDQELQHIRNSLPDSVQIRRVEERLSALGNVTTCNDYVALVHPDLDRETEEILADVLKVEVFRQTVADQVLVGSYCVFSNQGGLVHPKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVVESVFKLNEAKPSTIATSMRDSLIDSLT
uniprot
proteins
function
FUNCTION: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth. {ECO:0000255|HAMAP-Rule:MF_03132}.
uniprot
proteins
mass_dalton
26571
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export. {ECO:0000250|UniProtKB:P56537}.; PTM: Ufmylated by UFL1. {ECO:0000250|UniProtKB:O55135}.
uniprot
proteins
protein_family
EIF-6 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03132}. Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03132}. Note=Shuttles between cytoplasm and nucleus/nucleolus. {ECO:0000255|HAMAP-Rule:MF_03132}.
uniprot
proteins