PIGX
entrez
54965
canonical
uniprot
Q8TBF5
canonical
ensembl
ENSG00000163964
resolver
ensp
ENSP00000296333
resolver
ensp
ENSP00000376192
resolver
genesymbol
PIGX
resolver
hgnc
HGNC:26046
resolver
uniprot
Q9NWZ2
resolver
uniprot_entry
PIGX_HUMAN
resolver
uniprot_sec
Q9NWZ2
resolver
amino_acid_sequence
MAARVAAVRAAAWLLLGAATGLTRGPAAAFTAARSDAGIRAMCSEIILRQEVLKDGFHRDLLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLRERNITEAVMVSENFDIEAPNYLSKESEVLIYARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQEFPILKCWAHSEVAAPCALENEDICQWNKMKYKSVYKNVILQVPVGLTVHTSLVCSVTLLITILCSTLILVAVFKYGHFSL
uniprot
proteins
function
FUNCTION: Stabilizing subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM. {ECO:0000250|UniProtKB:Q60GF7}.
uniprot
proteins
mass_dalton
28788
uniprot
proteins
pathway_participation
PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000250|UniProtKB:Q60GF7}.
uniprot
proteins
protein_family
PIGX family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15635094
uniprot
proteins
pubmed
16641997
uniprot
proteins
sequence_length
258
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q60GF7}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q60GF7}.
uniprot
proteins
transmembrane_region
TRANSMEM 231..251; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins