Matn1
entrez
17180
canonical
uniprot
P51942
canonical
ensembl
ENSMUSG00000040533
resolver
ensp
ENSMUSP00000099636
resolver
enst
ENSMUST00000102576
resolver
genesymbol
Matn1
resolver
genesymbol_syn
Cmp
resolver
genesymbol_syn
Crtm
resolver
uniprot
Q80VN5
resolver
uniprot_entry
MATN1_MOUSE
resolver
uniprot_sec
Q80VN5
resolver
amino_acid_sequence
MKVTSGPAFALCSLLLLLLLLLQVPDSLSLVPQPRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGLVNYASTVKPEFPLRAHGSKASLLQAVRRIQPLSTGTMTGLALQFAITKALSDAEGGRARSPDISKVVIVVTDGRPQDSVRDVSERARASGIELFAIGVGRVDKATLRQIASEPQDEHVDYVESYNVIEKLAKKFQEAFCVVSDLCATGDHDCEQLCVSSPGSYTCACHEGFTLNSDGKTCNVCRGGGSGSATDLVFLIDGSKSVRPENFELVKKFINQIVDTLDVSDRLAQVGLVQYSSSIRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAARKAKDLGFKMFAVGVGNAVEEELREIASEPVADHYFYTADFKTINQIGKKLQKQICVEEDPCACESILKFEAKVEGLLQALTRKLEAVSGRLAVLENRII
uniprot
proteins
function
FUNCTION: A major component of the extracellular matrix of non-articular cartilage (By similarity). Binds to type 2 collagens and forms long concatenated protein networks as part of the extracellular matrix (By similarity). Required for the network-like organization and bundling of collagen fibrils surrounding chondrocytes in the zones of maturation and hypertrophy (PubMed:10633862). Required for mechanotransduction and adaption to mechanical loading in cartilage chondrocytes, resulting in an increase in expression of the extracellular matrix components ACAN and COL2A1 (PubMed:27270603). Acts as a moderator of angiogenesis in response to injury (PubMed:24692560). {ECO:0000250|UniProtKB:P05099, ECO:0000269|PubMed:10633862, ECO:0000269|PubMed:24692560, ECO:0000269|PubMed:27270603}.
uniprot
proteins
mass_dalton
54421
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; reduces binding affinity for type 2 collagens. {ECO:0000250|UniProtKB:P21941}.
uniprot
proteins
pubmed
10633862
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24692560
uniprot
proteins
pubmed
27270603
uniprot
proteins
pubmed
8665920
uniprot
proteins
sequence_length
500
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P05099}.
uniprot
proteins