CARD16
entrez
114769
canonical
uniprot
Q5EG05
canonical
ensembl
ENSG00000204397
resolver
ensp
ENSP00000509408
resolver
genesymbol
CARD16
resolver
genesymbol_syn
COP
resolver
genesymbol_syn
COP1
resolver
hgnc
HGNC:33701
resolver
uniprot
Q96RJ9
resolver
uniprot_entry
CAR16_HUMAN
resolver
uniprot_sec
Q96RJ9
resolver
amino_acid_sequence
MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTCSSPEGRIKLCFLEDAQRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQWLFLRTNFIERFWRNILLLPLHKGSLYPRIPGLGKELQTGTHKLS
uniprot
proteins
function
FUNCTION: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. {ECO:0000269|PubMed:11432859, ECO:0000269|PubMed:11536016, ECO:0000269|PubMed:16920334}.
uniprot
proteins
mass_dalton
22625
uniprot
proteins
pubmed
11432859
uniprot
proteins
pubmed
11536016
uniprot
proteins
pubmed
11821383
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16354923
uniprot
proteins
pubmed
16920334
uniprot
proteins
pubmed
21269460
uniprot
proteins
sequence_length
197
uniprot
proteins