Traf4
entrez
22032
canonical
uniprot
Q61382
canonical
ensembl
ENSMUSG00000017386
resolver
ensp
ENSMUSP00000017530
resolver
enst
ENSMUST00000017530
resolver
genesymbol
Traf4
resolver
genesymbol_syn
Cart1
resolver
uniprot
Q8BHD9
resolver
uniprot_entry
TRAF4_MOUSE
resolver
uniprot_sec
Q8BHD9
resolver
amino_acid_sequence
MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVVPCPNRCPAKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQCPRLPVPCPNQCGVGTVAREDLPTHLKDSCSTAFVLCPFKESGCKHRCPKLAMGRHVEESVKPHLAMMCALVSRQRQELQELRRELEELSIGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRASVELPRKILS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis. Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation. Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation. Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair. In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (By similarity). Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9BUZ4}.
uniprot
proteins
mass_dalton
53504
uniprot
proteins
mutagenesis
MUTAGEN 263; /note="K->R: Abolished ubiquitination by the SCF(FBXL2) complex."; /evidence="ECO:0000269|PubMed:23542741"; MUTAGEN 312; /note="W->A: Decreased interaction with FBXL2."; /evidence="ECO:0000269|PubMed:23542741
uniprot
proteins
pathway_participation
PATHWAY: Protein degradation; proteasomal ubiquitin-dependent pathway. {ECO:0000250|UniProtKB:Q9BUZ4}.
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated, leading to its proteasomal degradation (By similarity). Ubiquitinated at Lys-263 by the SCF(FBXL2) complex, leading to its degradation by the proteasome (PubMed:23542741). {ECO:0000250|UniProtKB:Q9BUZ4, ECO:0000269|PubMed:23542741}.
uniprot
proteins
protein_family
B subfamily
uniprot
proteins
protein_family
TNF receptor-associated factor family
uniprot
proteins
pubmed
10934170
uniprot
proteins
pubmed
11275257
uniprot
proteins
pubmed
11943846
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16157600
uniprot
proteins
pubmed
18284467
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23542741
uniprot
proteins
pubmed
9507120
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BUZ4}. Nucleus {ECO:0000250|UniProtKB:Q9BUZ4}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9BUZ4}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9BUZ4}. Cell membrane {ECO:0000250|UniProtKB:Q9BUZ4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BUZ4}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9BUZ4}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9BUZ4}.
uniprot
proteins