NCAPH2
entrez
29781
canonical
uniprot
Q6IBW4
canonical
ensembl
ENSG00000025770
resolver
ensp
ENSP00000299821
resolver
ensp
ENSP00000379050
resolver
ensp
ENSP00000410088
resolver
genesymbol
NCAPH2
resolver
genesymbol_syn
CAPH2
resolver
hgnc
HGNC:25071
resolver
uniprot
B7WPH1
resolver
uniprot
O43788
resolver
uniprot
Q13391
resolver
uniprot
Q96C14
resolver
uniprot
Q96GJ0
resolver
uniprot
Q9BQ71
resolver
uniprot
Q9BUT3
resolver
uniprot
Q9BVD1
resolver
uniprot_entry
CNDH2_HUMAN
resolver
uniprot_sec
B7WPH1
resolver
uniprot_sec
O43788
resolver
uniprot_sec
Q13391
resolver
uniprot_sec
Q96C14
resolver
uniprot_sec
Q96GJ0
resolver
uniprot_sec
Q9BQ71
resolver
uniprot_sec
Q9BUT3
resolver
uniprot_sec
Q9BVD1
resolver
amino_acid_sequence
MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKVEYLYSLVYQALDFISGKRRAKQLSSVQEDRANGVASSGVPQEAENEFLSLDDFPDSRTNVDLKNDQTPSEVLIIPLLPMALVAPDEMEKNNNPLYSRQGEVLASRKDFRMNTCVPHPRGAFMLEPEGMSPMEPAGVSPMPGTQKDTGRTEEQPMEVSVCRSPVPALGFSQEPGPSPEGPMPLGGGEDEDAEEAVELPEASAPKAALEPKESRSPQQSAALPRRYMLREREGAPEPASCVKETPDPWQSLDPFDSLESKPFKKGRPYSVPPCVEEALGQKRKRKGAAKLQDFHQWYLAAYADHADSRRLRRKGPSFADMEVLYWTHVKEQLETLRKLQRREVAEQWLRPAEEDHLEDSLEDLGAADDFLEPEEYMEPEGADPREAADLDAVPMSLSYEELVRRNVELFIATSQKFVQETELSQRIRDWEDTVQPLLQEQEQHVPFDIHTYGDQLVSRFPQLNEWCPFAELVAGQPAFEVCRSMLASLQLANDYTVEITQQPGLEMAVDTMSLRLLTHQRAHKRFQTYAAPSMAQP
uniprot
proteins
function
FUNCTION: Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}.
uniprot
proteins
mass_dalton
68227
uniprot
proteins
protein_family
CND2 H2 (condensin-2 subunit 2) family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12529303
uniprot
proteins
pubmed
14532007
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
605
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14532007}. Chromosome {ECO:0000269|PubMed:14532007}. Note=Distributed along the arms of chromosomes assembled in vivo and in vitro.
uniprot
proteins