GPR37L1
entrez
9283
canonical
uniprot
O60883
canonical
ensembl
ENSG00000170075
resolver
ensp
ENSP00000356251
resolver
enst
ENST00000367282
resolver
genesymbol
GPR37L1
resolver
genesymbol_syn
ETBRLP2
resolver
hgnc
HGNC:14923
resolver
uniprot
B2R7M9
resolver
uniprot
Q5SXP7
resolver
uniprot
Q86VP7
resolver
uniprot_entry
G37L1_HUMAN
resolver
uniprot_sec
B2R7M9
resolver
uniprot_sec
Q5SXP7
resolver
uniprot_sec
Q86VP7
resolver
amino_acid_sequence
MRWLWPLAVSLAVILAVGLSRVSGGAPLHLGRHRAETQEQQSRSKRGTEDEEAKGVQQYVPEEWAEYPRPIHPAGLQPTKPLVATSPNPGKDGGTPDSGQELRGNLTGAPGQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPAPTMGTLDSCIMKPSASLPESLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKSECRASKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANGSDNKLKTEVSSSIYFHKPRESPPLLPLGTPC
uniprot
proteins
function
FUNCTION: G protein-coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity). {ECO:0000250|UniProtKB:Q99JG2, ECO:0000269|PubMed:23690594, ECO:0000269|PubMed:27072655, ECO:0000269|PubMed:28688853}.
uniprot
proteins
mass_dalton
52771
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000269|PubMed:23234360}.; PTM: Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity. {ECO:0000269|PubMed:27072655}.; PTM: Ubiquitinated. {ECO:0000269|PubMed:28688853}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
23234360
uniprot
proteins
pubmed
23690594
uniprot
proteins
pubmed
27072655
uniprot
proteins
pubmed
28688853
uniprot
proteins
pubmed
9539149
uniprot
proteins
sequence_length
481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28688853}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q99JG2}; Multi-pass membrane protein {ECO:0000255}. Note=Associates with the basal membrane of Bergmann glia cell primary cilia. {ECO:0000250|UniProtKB:Q99JG2}.
uniprot
proteins
transmembrane_region
TRANSMEM 135..155; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 206..226; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 252..272; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 399..419; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins