Krt15
entrez
16665
canonical
uniprot
Q61414
canonical
ensembl
ENSMUSG00000054146
resolver
ensp
ENSMUSP00000103034
resolver
enst
ENSMUST00000107411
resolver
genesymbol
Krt15
resolver
genesymbol_syn
Krt1-15
resolver
uniprot
B1AQ77
resolver
uniprot
Q6PEQ0
resolver
uniprot_entry
B1AQ77_MOUSE
resolver
uniprot_entry
K1C15_MOUSE
resolver
uniprot_sec
Q6PEQ0
resolver
amino_acid_sequence
MATTFLQTSSTFGGSSTRGASLRAGGGSFGGGSLYGGGGSRSISASSARFVSSGAGGGFGGGMSCGFGGGFGGGFGGGFGGGFGDFGGGDGGLLSGNEKVTMQNLNDRLASYLDKVRALEQANTELEVKIRDWYQKQSPASPDRDYSHYFKTMEEIRDKILAATIDNSRVVLEIDNARLAADDFRLKYENELTLRQGVEADINGLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRMLAEMREQYEAIAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTLQGLEIELQSQLSMKAGLENSLAEVECRYATQLQQIQGVITGLETQLSELRCEMEAQNQEYNMLLDIKTRLEQEIATYRNLLEGQDAKMAGIGVREGSSGGGGSSSSSSNFHISVEESVDGKVVSSRKREI
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in the epithelium. Forms heteropolymers with type II keratin KRT5, assembling into keratin intermediate filament network that promotes mechanical resilience of undifferentiated cells, including hair follicle bulge cells, foregut basal progenitors and intestinal crypt cells (PubMed:14708593, PubMed:29805107, PubMed:7539810). Dislays an antagonist role with KRT14 in basal epithelial cells, where KRT14 promotes cell differentiation while KRT15 maintains the progenitor state and promotes proliferation and clonogenicity (PubMed:10623468, PubMed:36512409). Promotes the progenitor state in basal keratinocytes by maintaining cytoplasmic YAP1 less effectively than KRT14 due to missing biochemical motifs, thereby allowing higher YAP1 nuclear activity (By similarity). Also contributes to epithelial cell regeneration after injury (PubMed:29805107, PubMed:36512409). In the absence of KRT14, forms a bona fide, but ultrastructurally distinct keratin filament network with KRT5 (PubMed:7539810). {ECO:0000250|UniProtKB:P19012, ECO:0000269|PubMed:10623468, ECO:0000269|PubMed:14708593, ECO:0000269|PubMed:29805107, ECO:0000269|PubMed:36512409, ECO:0000269|PubMed:7539810}.
uniprot
proteins
mass_dalton
49138
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
10623468
uniprot
proteins
pubmed
11408584
uniprot
proteins
pubmed
14506658
uniprot
proteins
pubmed
14708593
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29805107
uniprot
proteins
pubmed
36512409
uniprot
proteins
pubmed
7510260
uniprot
proteins
pubmed
7539810
uniprot
proteins
sequence_length
452
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14708593}.
uniprot
proteins