Hspa1l
entrez
15482
canonical
uniprot
P16627
canonical
ensembl
ENSMUSG00000007033
resolver
ensp
ENSMUSP00000007248
resolver
enst
ENSMUST00000007248
resolver
genesymbol
Hspa1l
resolver
genesymbol_syn
Hsc70t
resolver
uniprot
A1L347
resolver
uniprot
O88686
resolver
uniprot
Q61693
resolver
uniprot_entry
A1L347_MOUSE
resolver
uniprot_entry
HS71L_MOUSE
resolver
uniprot_sec
O88686
resolver
uniprot_sec
Q61693
resolver
amino_acid_sequence
MAANKGMAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDAKRLIGRKFNDPVVQSDMKLWPFQVINEAGKPKVMVSYKGEKKAFYPEEISSMVLTKMKETAEAFLGHNVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGSHGERHVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKSLRDAKMDKAKIHDIVLVGGSTRIPKVQKLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLLDVAPLSLGLETAGGVMTVLIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAMDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEGQREKIAAKNALESYAFNMKSAVGDEGLKDKISESDKKKILDKCNEVLSWLEANQLAEKDEFDHKRKELENMCNPIITKLYQSGCTGPTCTPGYTPGRAATGPTIEEVD
uniprot
proteins
function
FUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria. {ECO:0000250|UniProtKB:P34931}.
uniprot
proteins
mass_dalton
70637
uniprot
proteins
protein_family
Heat shock protein 70 family
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2302214
uniprot
proteins
pubmed
8026864
uniprot
proteins
pubmed
9685725
uniprot
proteins
sequence_length
641
uniprot
proteins