Rnf170
entrez
77733
canonical
uniprot
Q8CBG9
canonical
ensembl
ENSMUSG00000013878
resolver
ensp
ENSMUSP00000014022
resolver
ensp
ENSMUSP00000118689
resolver
ensp
ENSMUSP00000289762
resolver
ensp
ENSMUSP00000289767
resolver
ensp
ENSMUSP00000289779
resolver
genesymbol
Rnf170
resolver
uniprot
A6H618
resolver
uniprot
Q3U796
resolver
uniprot
Q78QX6
resolver
uniprot
Q8C8S1
resolver
uniprot
Q8C9I0
resolver
uniprot
Q8K0H6
resolver
uniprot_entry
RN170_MOUSE
resolver
uniprot_sec
A6H618
resolver
uniprot_sec
Q3U796
resolver
uniprot_sec
Q78QX6
resolver
uniprot_sec
Q8C8S1
resolver
uniprot_sec
Q8C9I0
resolver
uniprot_sec
Q8K0H6
resolver
amino_acid_sequence
MQRYWRFQDNKIQDICFGVLGESWIQRPVMARYYSEGQSLQQDDSFIEGVSDQVLVAVVVSLALTATLLYALLRNVQQNIHPENQELVRVLREQFQTEQDVPAPARQQFYTEMYCPICLHQASFPVETNCGHLFCGSCIIAYWRYGSWLGAISCPICRQTVTLLLTVFGEDDQSQDVIRLRQDVNDYNRRFSGQPRSIMERIMDLPTLLRHAFREVFSVGGLFWMFRIRIMLCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLLLIYISIMYREVITQRLTR
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Selectively inhibits the TLR3-triggered innate immune response by promoting the 'Lys-48'-linked polyubiquitination and degradation of TLR3 (PubMed:31076723). {ECO:0000269|PubMed:21610068, ECO:0000269|PubMed:31076723}.
uniprot
proteins
mass_dalton
33414
uniprot
proteins
mutagenesis
MUTAGEN 130; /note="C->S: Loss of E3 ligase activity."; /evidence="ECO:0000269|PubMed:21610068"; MUTAGEN 132; /note="H->S: Loss of E3 ligase activity."; /evidence="ECO:0000269|PubMed:21610068
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21610068
uniprot
proteins
pubmed
31076723
uniprot
proteins
sequence_length
286
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21610068}; Multi-pass membrane protein {ECO:0000269|PubMed:21610068}.
uniprot
proteins
transmembrane_region
TRANSMEM 53..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 230..250; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 252..272; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins