ELMO1
entrez
9844
canonical
uniprot
Q92556
canonical
ensembl
ENSG00000155849
resolver
ensp
ENSP00000312185
resolver
ensp
ENSP00000379355
resolver
ensp
ENSP00000379360
resolver
ensp
ENSP00000394458
resolver
ensp
ENSP00000406952
resolver
ensp
ENSP00000569026
resolver
ensp
ENSP00000569027
resolver
ensp
ENSP00000569028
resolver
ensp
ENSP00000706560
resolver
ensp
ENSP00000750471
resolver
ensp
ENSP00000779005
resolver
genesymbol
ELMO1
resolver
genesymbol_syn
KIAA0281
resolver
hgnc
HGNC:16286
resolver
uniprot
A4D1X5
resolver
uniprot
A4D1X6
resolver
uniprot
Q29R79
resolver
uniprot
Q6ZTJ0
resolver
uniprot
Q96PB0
resolver
uniprot
Q9H0I1
resolver
uniprot_entry
A4D1X5_HUMAN
resolver
uniprot_entry
ELMO1_HUMAN
resolver
uniprot_sec
A4D1X6
resolver
uniprot_sec
Q29R79
resolver
uniprot_sec
Q6ZTJ0
resolver
uniprot_sec
Q96PB0
resolver
uniprot_sec
Q9H0I1
resolver
amino_acid_sequence
MPPPADIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQHADSSNFYITEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDAKLEALKDLASLSRDVTFAQEFINLDGISLLTQMVESGTERYQKLQKIMKPCFGDMLSFTLTAFVELMDHGIVSWDTFSVAFIKKIASFVNKSAIDISILQRSLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGSDQEIQTYTIAVINALFLKAPDERRQEMANILAQKQLRSIILTHVIRAQRAINNEMAHQLYVLQVLTFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKRKSMYTRDYKKLGFINHVNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSETCNDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQSRPILELKEKIQPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDAPPPIPKEPSNYDFVYDCN
uniprot
proteins
function
FUNCTION: Regulates the activity of DOCK guanine nucleotide exchange factors (GEFs) (PubMed:11595183, PubMed:12134158, PubMed:32651375, PubMed:38857861). Acts in association with DOCK1, DOCK2, DOCK5 and CRK (PubMed:11595183, PubMed:12134158, PubMed:32651375, PubMed:38857861). Promotes RAC1 activation by DOCK5; the activity is stimulated by RHOG (PubMed:38857861). Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility (PubMed:11595183). {ECO:0000269|PubMed:11595183, ECO:0000269|PubMed:12134158, ECO:0000269|PubMed:32651375, ECO:0000269|PubMed:38857861}.
uniprot
proteins
mass_dalton
83829
uniprot
proteins
mutagenesis
MUTAGEN 9; /note="K->A: Decreases binding to RHOG."; /evidence="ECO:0000269|PubMed:36932164"; MUTAGEN 13; /note="E->A: Decreases binding to RHOG."; /evidence="ECO:0000269|PubMed:36932164"; MUTAGEN 21; /note="L->A: Decreases binding to RHOG."; /evidence="ECO:0000269|PubMed:36932164"; MUTAGEN 36..39; /note="EVCD->AVCA: Increases the GEF activity of DOCK5/ELMO1 against RAC1."; /evidence="ECO:0000269|PubMed:38857861
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by HCK. {ECO:0000305|PubMed:12029088, ECO:0000305|PubMed:15952790}.
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11595183
uniprot
proteins
pubmed
12029088
uniprot
proteins
pubmed
12134158
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15952790
uniprot
proteins
pubmed
17881735
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20869035
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24567399
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
32651375
uniprot
proteins
pubmed
36932164
uniprot
proteins
pubmed
38857861
uniprot
proteins
pubmed
9179496
uniprot
proteins
sequence_length
727
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.
uniprot
proteins