Pik3cd
entrez
18707
canonical
uniprot
O35904
canonical
ensembl
ENSMUSG00000039936
resolver
ensp
ENSMUSP00000036434
resolver
ensp
ENSMUSP00000101313
resolver
ensp
ENSMUSP00000101314
resolver
ensp
ENSMUSP00000101315
resolver
ensp
ENSMUSP00000112863
resolver
ensp
ENSMUSP00000136045
resolver
ensp
ENSMUSP00000314744
resolver
ensp
ENSMUSP00000314746
resolver
ensp
ENSMUSP00000314749
resolver
ensp
ENSMUSP00000314751
resolver
ensp
ENSMUSP00000314752
resolver
ensp
ENSMUSP00000314754
resolver
ensp
ENSMUSP00000314758
resolver
enst
ENSMUST00000038859
resolver
enst
ENSMUST00000105688
resolver
enst
ENSMUST00000105690
resolver
enst
ENSMUST00000118704
resolver
enst
ENSMUST00000177654
resolver
genesymbol
Pik3cd
resolver
uniprot
F6U6P2
resolver
uniprot
F7CMJ1
resolver
uniprot
F7CMK9
resolver
uniprot
F8WHQ7
resolver
uniprot
Q3T9Y0
resolver
uniprot
Q3TBW3
resolver
uniprot
Q3UDT3
resolver
uniprot
Q8BS14
resolver
uniprot
Q8CI98
resolver
uniprot
Q8CJ28
resolver
uniprot_entry
F6U6P2_MOUSE
resolver
uniprot_entry
F7CMJ1_MOUSE
resolver
uniprot_entry
F7CMK9_MOUSE
resolver
uniprot_entry
F8WHQ7_MOUSE
resolver
uniprot_entry
PK3CD_MOUSE
resolver
uniprot_entry
Q3T9Y0_MOUSE
resolver
uniprot_entry
Q3TBW3_MOUSE
resolver
uniprot_entry
Q3UDT3_MOUSE
resolver
uniprot_entry
Q8BS14_MOUSE
resolver
uniprot_entry
Q8CI98_MOUSE
resolver
uniprot_sec
Q8CJ28
resolver
activity_regulation
ACTIVITY REGULATION: Activated by growth factors and cytokine receptors through a tyrosine-kinase-dependent mechanism. Activated by RAS. IC87114 inhibits lipid kinase activity and is selective in cells at doses up to 5-10 uM. Among other effects, IC87114 reduces allergic responses, prevents the recruitment of antigen-specific T cells into target tissue, and affects natural killer cell chemotaxis. {ECO:0000269|PubMed:15496927, ECO:0000269|PubMed:18259608, ECO:0000269|PubMed:19297623}.
uniprot
proteins
amino_acid_sequence
MPPGVDCPMEFWTKEESQSVVVDFLLPTGVYLNFPVSRNANLSTIKQVLWHRAQYEPLFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWVEWLQYSFPLQLEPSARGWRAGLLRVSNRALLVNVKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVEQPEEYALQVNGRHEYLYGNYPLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFSIELIEGRKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMARLCFALYAVVEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPAGTVRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRITEEELQLREILERRGSGELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDSKMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ
uniprot
proteins
ec_number
2.7.1.137
uniprot
proteins
ec_number
2.7.1.153
uniprot
proteins
function
FUNCTION: Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:9235916). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Plays a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Plays important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. {ECO:0000269|PubMed:12130661, ECO:0000269|PubMed:12235209, ECO:0000269|PubMed:15496927, ECO:0000269|PubMed:16116162, ECO:0000269|PubMed:18259608, ECO:0000269|PubMed:18809712, ECO:0000269|PubMed:19297623, ECO:0000269|PubMed:9235916}.
uniprot
proteins
mass_dalton
119712
uniprot
proteins
mutagenesis
MUTAGEN 910; /note="D->A: Inhibits lipid kinase activity. Mice are viable and fertile but display defective adaptive and innate immune responses Signaling defects in B-cells, T-cells, mast cells and natural killer cells. Reduced B and T-cell receptor signaling. Affects development and differentiation of B -ells. Reduced memory T-cell number. Affects B- and T-cell proliferation. Attenuates immune responses in vivo. Induces inflammatory bowel disease development. Lost TCR-induced migration and localization to antigenic tissue. Affects natural killer cell maturation and cytokine production."; /evidence="ECO:0000269|PubMed:12130661, ECO:0000269|PubMed:15496927, ECO:0000269|PubMed:18259608, ECO:0000269|PubMed:18809712
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis. {ECO:0000305|PubMed:9235916}.
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation on Ser-1038 results in the almost complete inactivation of the lipid kinase activity. {ECO:0000250}.
uniprot
proteins
protein_family
PI3/PI4-kinase family
uniprot
proteins
pubmed
12130661
uniprot
proteins
pubmed
12235209
uniprot
proteins
pubmed
12774123
uniprot
proteins
pubmed
15496927
uniprot
proteins
pubmed
16116162
uniprot
proteins
pubmed
18259608
uniprot
proteins
pubmed
18809712
uniprot
proteins
pubmed
19297623
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20081827
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22020336
uniprot
proteins
pubmed
9235916
uniprot
proteins
sequence_length
1043
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins