Acvr1c
entrez
245921
canonical
uniprot
P70539
canonical
ensembl
ENSRNOG00000004828
resolver
ensp
ENSRNOP00000056047
resolver
enst
ENSRNOT00000059280
resolver
genesymbol
Acvr1c
resolver
genesymbol_syn
Alk7
resolver
uniprot
F1LQM3
resolver
uniprot
P70603
resolver
uniprot_entry
ACV1C_RAT
resolver
uniprot_entry
F1LQM3_RAT
resolver
uniprot_sec
P70603
resolver
amino_acid_sequence
MTPARRSALSLALLLVALASDLAAGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVSKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITQHLPTASPDAPRLGPTELTVVITVPVCLLSIAAMLTIWACQDRQCTYRKTKRHNVEEPLAEYSLVNAGKTLKDLIYDATASGSGSGPPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGLVEEYQLPYYDMVPSDPSIEEMRKVVCDQKLRPNLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVKEDCKA
uniprot
proteins
ec_number
2.7.11.30
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL (PubMed:15196700). Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells (PubMed:9920806, PubMed:11084022, PubMed:22550067). Acts as a positive regulator for macrophage activation partially through down-regulation of PPARG expression (By similarity). {ECO:0000250|UniProtKB:Q8K348, ECO:0000250|UniProtKB:Q8NER5, ECO:0000269|PubMed:11084022, ECO:0000269|PubMed:15196700, ECO:0000269|PubMed:22550067, ECO:0000269|PubMed:8875430, ECO:0000269|PubMed:9920806}.
uniprot
proteins
mass_dalton
54842
uniprot
proteins
mutagenesis
MUTAGEN 194; /note="T->D: Constitutively activates downstream transcription factor function."; /evidence="ECO:0000269|PubMed:8875430, ECO:0000269|PubMed:9920806"; MUTAGEN 222; /note="K->R: Fails to activate downstream transcription factor function."; /evidence="ECO:0000269|PubMed:8875430
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TGFB receptor subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
11084022
uniprot
proteins
pubmed
15196700
uniprot
proteins
pubmed
22550067
uniprot
proteins
pubmed
8875430
uniprot
proteins
pubmed
8940033
uniprot
proteins
pubmed
9920806
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:15196700}; Single-pass type I membrane protein {ECO:0000269|PubMed:15196700}.
uniprot
proteins
transmembrane_region
TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins