Pcgf6
entrez
309457
canonical
uniprot
Q5XI70
canonical
ensembl
ENSRNOG00000020250
resolver
ensp
ENSRNOP00000027450
resolver
ensp
ENSRNOP00000077535
resolver
ensp
ENSRNOP00000112266
resolver
enst
ENSRNOT00000027450
resolver
enst
ENSRNOT00000094399
resolver
genesymbol
Pcgf6
resolver
genesymbol_syn
Rnf134
resolver
uniprot
A0A8I5XW83
resolver
uniprot
A0A8L2QF06
resolver
uniprot_entry
A0A8I5XW83_RAT
resolver
uniprot_entry
A0A8L2QF06_RAT
resolver
uniprot_entry
PCGF6_RAT
resolver
amino_acid_sequence
MEEAETDATENKRASEAKRASAMLPPPPPPISPPALIPAPAAGEEGPASLAQAGAPGCSRSRPPELEPERSLGRLRGRFEDYDEELEEDEEMEEEEEEEEEMSHFSLRLESGRADSEDEEERLINLVELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVVNLEEREKKQMHDFYKERGLEVPKPAVPQPVPASKGRTKKALESVFRIPPELDVSLLLEFIGANEDTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLERYQTLREIRRAIGDTAMQDGLLVLHYGLVVSPLKIT
uniprot
proteins
function
FUNCTION: Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. {ECO:0000250|UniProtKB:Q9BYE7}.
uniprot
proteins
mass_dalton
39706
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during mitosis. {ECO:0000250|UniProtKB:Q9BYE7}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BYE7}.
uniprot
proteins