Pgap6
entrez
60455
canonical
uniprot
Q9ESN3
canonical
ensembl
ENSMUSG00000024180
resolver
ensp
ENSMUSP00000025010
resolver
genesymbol
Pgap6
resolver
genesymbol_syn
Tmem8
resolver
genesymbol_syn
Tmem8a
resolver
uniprot
Q543X8
resolver
uniprot
Q99JS5
resolver
uniprot_entry
PGAP6_MOUSE
resolver
uniprot_sec
Q543X8
resolver
uniprot_sec
Q99JS5
resolver
amino_acid_sequence
MGRVGAGGTAREAATGSLLLLLLLLARPPPAAASNSKESEAGLVSEHFSQAPQKLSFYSWYGSTRLFHFRVPPDTVLLRWLLHVSQGSPSCTDEEITVHFRYGAPPVINPLGTSFPDNTLSHASFHIRALLSTLMLDNTSVNISHPAPGDWFLVAHLPPSSQKIQVKGFVPTCAYIFQPDMLVMRVVEVSTLEPDVPLPQTLLSYPSYLKIFVPEYTQELRLELQGCVSSVSPGCPVRVTVGATTLPRNFQRVLTCTGLAPSCHLLLSSPPWGRWLQVTFESLAEPHVTVGFTAKAVFTVCRPWSVTIHHLIQNNPNQTYDTSAIQLSQSAVHRDLGRSSRVDSGPFCLLNYPVLREDTDVVSVHFQPLNGAFVLVHSSMPSVMQLRLDTGMDSGGSFIIVLRTNKTEVTNGTLVAACVNAASPFLSFNTSLNCTTAFFQGYPMFLRASSHMANLIMPFPETDNWYLSLQLVCPESPEDCEQAVVRVETILYLVPCLNDCGPYGQCLLLRRYGYVYAGCSCKAGWRGWSCTDNSTAQTVAQQRAAALLLTLSNLMFLAPIAISLHRSFLVEASVYFYTMFFSTFYHACDQPGEAVLCILSYDTLQYCDFLGSGASTWVTILCMARLKTILKQVLLVLGTLVIAMSLQMDRRGIWNLMGPCVFAFVIMASMWIYRCGHRGQCYPTSWQRWVFYLLPGISMASVGIAMYTSMMTSDNYYYTHSIWHILLAGSAAFLLPPREEKAGSWACLQKFPCHYQICRNDRDELYTVT
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP CRIPTO, but not CFC1, at the cell surface. Shedding of CRIPTO modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane. {ECO:0000250|UniProtKB:Q9HCN3}.
uniprot
proteins
mass_dalton
85329
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q9HCN3}.
uniprot
proteins
protein_family
TMEM8 family
uniprot
proteins
pubmed
11006113
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
27881714
uniprot
proteins
sequence_length
769
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9HCN3}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q9HCN3}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 544..564; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 568..588; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 604..624; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 628..648; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 652..672; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 689..709; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 716..736; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins