Terb1
entrez
320022
canonical
uniprot
Q8C0V1
canonical
ensembl
ENSMUSG00000052616
resolver
ensp
ENSMUSP00000067324
resolver
ensp
ENSMUSP00000219782
resolver
genesymbol
Terb1
resolver
genesymbol_syn
Ccdc79
resolver
uniprot
A1L2Z9
resolver
uniprot
E9QPF2
resolver
uniprot
Q14CI1
resolver
uniprot
Q8C0N5
resolver
uniprot
U6C3P6
resolver
uniprot_entry
TERB1_MOUSE
resolver
uniprot_entry
U6C3P6_MOUSE
resolver
uniprot_sec
A1L2Z9
resolver
uniprot_sec
E9QPF2
resolver
uniprot_sec
Q14CI1
resolver
uniprot_sec
Q8C0N5
resolver
amino_acid_sequence
MESEKPKKTQEMKTDLKLLLECLKYHMGNPLSQKEVLITIHSVCKQNSDAGIYFREIGGLMFIINLAKSSEQSLVKEAALYTLGSIAEENVYCQQSLCTSELFQDLTGLLTNDDSNTNLKRMSVYVLLVLVSNNRNGQTLVREVGCIEVLSQMFRTVLSNYELNLSDNSVFQSYLLWSSVCSTLCVCVNNPQNDENQMLCCSLFPCVNEWLMNCMRPEVIRPICSFIGLTLANNTHAQNCFVSSGGLDVLCQVLVQLESDSHNTLSSAKLAVIVTKTMDACITDNSAAFTVVLSKYHIVSTLLALLLHESLDSREKFSIILAIGHCTEDCEKNQYELLKNNGLPLMIQALTEFKNEDLSKAATYVLHNCKKITGKLSLSLGQNSFGENEIELKDISEKETLREHWKAAKEILCRIKQFEKGGKEEKQQNRSGHYKDNTPSMKVNIQTNLKRLCADSTGGTRAEDKDINQSRELRSYKPSEIMSKACANENQLTTRKKNTNPVHPFCKEKGQSKIVHETTPSCAQNLDKEKTFDQKDSVSQSSDQVLKHLPHTVKNRKQVPETDPFTLCLDIIDREVGIQATDSCSRMLKYTCSGCIVARKLLNSRNFSKFLHSCAYQCVHHKVIMEAEDKYKNELRKTFICAKKILLTPCRRRQLCKESTASEELKIVHQKPDSKKLPGLEAQALNTSIPEAMERRSPVPGQSGLHKKRRIRKDFTKEEVNYLFHGVKTMGNHWNSILWSFPFQKGRRAVDLAHKYHRLIKGPSCAAL
uniprot
proteins
function
FUNCTION: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis (PubMed:24413433, PubMed:24885367, PubMed:26548954). Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA (PubMed:26548954). In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment' (PubMed:26548954). Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex (PubMed:24413433, PubMed:24885367). Also recruits cohesin to telomeres to develop structural rigidity (PubMed:24413433). {ECO:0000269|PubMed:24413433, ECO:0000269|PubMed:26548954, ECO:0000305|PubMed:24885367}.
uniprot
proteins
mass_dalton
86835
uniprot
proteins
mutagenesis
MUTAGEN 648; /note="T->A: Telomere-attachment defects."; /evidence="ECO:0000269|PubMed:26548954"; MUTAGEN 648; /note="T->D: Mimics phosphorylation state; impairs interaction with TERF1."; /evidence="ECO:0000269|PubMed:24413433
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK (PubMed:24413433, PubMed:26548954). Phosphorylation by CDK takes place in late prophase when the cap exchange is prominent (PubMed:26548954). is important for the stabilization of telomere attachment but dispenable for the cap exchange (PubMed:26548954). {ECO:0000269|PubMed:24413433, ECO:0000269|PubMed:26548954}.
uniprot
proteins
protein_family
TERB1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24413433
uniprot
proteins
pubmed
24885367
uniprot
proteins
pubmed
26548954
uniprot
proteins
sequence_length
768
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome, telomere {ECO:0000269|PubMed:24413433, ECO:0000269|PubMed:24885367}. Nucleus inner membrane {ECO:0000269|PubMed:26548954}. Note=Localizes to telomeres during meiotic prophase (PubMed:24413433). In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane (PubMed:26548954). {ECO:0000269|PubMed:24413433, ECO:0000269|PubMed:26548954}.
uniprot
proteins