Stil
entrez
20460
canonical
uniprot
Q60988
canonical
ensembl
ENSMUSG00000028718
resolver
ensp
ENSMUSP00000030490
resolver
ensp
ENSMUSP00000228163
resolver
enst
ENSMUST00000030490
resolver
genesymbol
Stil
resolver
genesymbol_syn
Sil
resolver
uniprot
A0A0A6YYN4
resolver
uniprot
A0A0K0K1B0
resolver
uniprot
A0AAA9U4T8
resolver
uniprot
A2AD39
resolver
uniprot
F6WX10
resolver
uniprot
Q80VK7
resolver
uniprot
Q8BQI9
resolver
uniprot
Q8C7U6
resolver
uniprot
Q8CEL7
resolver
uniprot
Q99KL4
resolver
uniprot_entry
A0AAA9U4T8_MOUSE
resolver
uniprot_entry
Q8BQI9_MOUSE
resolver
uniprot_entry
STIL_MOUSE
resolver
uniprot_sec
A0A0A6YYN4
resolver
uniprot_sec
A0A0K0K1B0
resolver
uniprot_sec
A2AD39
resolver
uniprot_sec
F6WX10
resolver
uniprot_sec
Q80VK7
resolver
uniprot_sec
Q8C7U6
resolver
uniprot_sec
Q8CEL7
resolver
uniprot_sec
Q99KL4
resolver
amino_acid_sequence
MNTRFPSSKMVPFHFPPSKLALWNPMPIGECIYLHLSYYRKPKLMVTEKAIRLAYRHAKQNKKNVPCFLLGSLTVDEDEEGVTLTIDRFDPGREIPECLERTPTASLPGDFLIPCRVHIQGLGSRDVIVHNADDFSSALKALQYHVCSKDFLDCGKLLCLRAQITPRESLDGVDFNLQWTAVTLANSFKCVPVKPIPIIPTALARNLSSNLNISQVQGTYKHGYITMDETRKLLLLLQSDPKVSSLPLVGIWLAGIIHVYSPQVWACCLRYMFSSSIQERVFSESGNFIIVLYSLTHKEPEFYECLPCESRTPDLQFQLLTNKETLHLFNNVEPSGKNPIHFELSAESQDAEAEAEVLSKISKTLPVKRSSQKLSPGKIPINKHDTDLEDEDFSPRPIPSPHPVSQKISKVQPSVPELSLVLDNNFTESSNQSNPLEMMTVENPLLIKPSQPELCDAKHSSEATTGEPFRRGPTNQLSQDTALRQSRGKQSSTCKKESLQFRNTNAKPSLSVPSPDVAEKLQAVSAGSMQKEDYPVRPSTLDSRQPSLAPQAQPHNLVFSTHNSTRPMELQVPTPSLPSYYPTNVCSCCQHHGHIQYSTINSWQGNTVGSIQDLRSESLPKHAFFHSSGCPSLCPNAIYSSSSPVSMKQGGMGAYSPHSNGEPSPVAGPSHVDSCVPHPCAMCMHTPNTAPDNGMMGLSPDAYRFVTEQDRQLRLLQAQIQRLLEAQSLDPGSHKTVATVEDTVKAAKQMELVSMEAQSSPGLHMRKSVSIAVSTGASLFWNAAGDDQEPDSQPKQDDTKISSEDMNFSVDINNEATSLPGSASSLKAVDIPSFEESNLAVEEVNQPLPESNSSSEQSKEPGVPVFFPNALLAESVSMCLQTAPTEGASNSTELPQGTKDEPYRPSDNQKIYQDLLGQVNHLLSNASQETEEPPTKAVVTNRECAKTQNTHHARKKRHNSGLVDKDCVLSATIKQLRSLGVKIDSPTKVKKNEQKVDHASVLACISPEAVISGLNYMSFGNVGMSSLSPTGVDLSMEANAIALKYLSENQLSQLSLARSKQNNGDSSVGLLHINSDRSTVGLSLVSPSNMSFATKKYMKRYGLLQSSDNSEDEEEPPSHADSESDHVLNRNPACRPVQCGHEKEPSWNACEIAQCSDCGSADTRTDVPVLRNITNQAVQPRATEHLNEDSAISLRNLKPNPAMNLRTGKAEFTHHPEKENERDIAVFPGTLPSPETLKQMNSMDSVGTFLDVKRLRQLPKLF
uniprot
proteins
function
FUNCTION: Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (By similarity). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (By similarity). {ECO:0000250|UniProtKB:Q15468, ECO:0000269|PubMed:10385121, ECO:0000269|PubMed:11668681, ECO:0000269|PubMed:8825637}.
uniprot
proteins
mass_dalton
138730
uniprot
proteins
mutagenesis
MUTAGEN 574; /note="T->A: Abolishes mitotic phosphorylation and decreases mitotic index as well as CDK1 activity; when associated with A-643; A-656; A-664; A-686; A-699 and A-760."; /evidence="ECO:0000269|PubMed:16024801"; MUTAGEN 643; /note="S->A: Abolishes mitotic phosphorylation and decreases mitotic index as well as CDK1 activity; when associated with A-574; A-656; A-664; A-686; A-699 and A-760."; /evidence="ECO:0000269|PubMed:16024801"; MUTAGEN 656; /note="S->A: Abolishes mitotic phosphorylation and decreases mitotic index as well as CDK1 activity; when associated with A-574; A-643; A-664; A-686; A-699 and A-760."; /evidence="ECO:0000269|PubMed:16024801"; MUTAGEN 664; /note="S->A: Abolishes mitotic phosphorylation and decreases mitotic index as well as CDK1 activity; when associated with A-574; A-643; A-656; A-686; A-699 and A-760."; /evidence="ECO:0000269|PubMed:16024801"; MUTAGEN 686; /note="T->A: Abolishes mitotic phosphorylation and decreases mitotic index as well as CDK1 activity; when associated with A-574; A-643; A-656; A-664; A-699 and A-760."; /evidence="ECO:0000269|PubMed:16024801"; MUTAGEN 699; /note="S->A: Abolishes mitotic phosphorylation and decreases mitotic index as well as CDK1 activity; when associated with A-574; A-643; A-656; A-664; A-686 and A-760."; /evidence="ECO:0000269|PubMed:16024801"; MUTAGEN 760; /note="S->A: Abolishes mitotic phosphorylation and decreases mitotic index as well as CDK1 activity; when associated with A-574; A-643; A-656; A-664; A-686 and A-699."; /evidence="ECO:0000269|PubMed:16024801
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. {ECO:0000250|UniProtKB:Q15468}.; PTM: Phosphorylated following the activation of the mitotic checkpoint. {ECO:0000305|PubMed:16024801}.
uniprot
proteins
pubmed
10385121
uniprot
proteins
pubmed
11156618
uniprot
proteins
pubmed
11668681
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16024801
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1922059
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8825637
uniprot
proteins
sequence_length
1262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q15468}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q15468}. Note=Localizes at the leading edge. {ECO:0000250|UniProtKB:Q15468}.
uniprot
proteins