PTOV1
entrez
53635
canonical
uniprot
Q86YD1
canonical
ensembl
ENSG00000104960
resolver
ensp
ENSP00000375717
resolver
ensp
ENSP00000469128
resolver
ensp
ENSP00000469541
resolver
ensp
ENSP00000471458
resolver
ensp
ENSP00000472816
resolver
enst
ENST00000600603
resolver
enst
ENST00000601638
resolver
genesymbol
PTOV1
resolver
genesymbol_syn
ACID2
resolver
hgnc
HGNC:9632
resolver
uniprot
A0A0C4DGR2
resolver
uniprot
M0QY25
resolver
uniprot
Q6UXX7
resolver
uniprot
Q96BU3
resolver
uniprot
Q9HBN4
resolver
uniprot
Q9NYL1
resolver
uniprot_entry
A0A0C4DGR2_HUMAN
resolver
uniprot_entry
M0QY25_HUMAN
resolver
uniprot_entry
PTOV1_HUMAN
resolver
uniprot_sec
Q6UXX7
resolver
uniprot_sec
Q96BU3
resolver
uniprot_sec
Q9HBN4
resolver
uniprot_sec
Q9NYL1
resolver
amino_acid_sequence
MVRPRRAPYRSGAGGPLGGRGRPPRPLVVRAVRSRSWPASPRGPQPPRIRARSAPPMEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIPQQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTRKQAVGPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQGEILRTEQWPRKLYMQLIPQQLLTTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFAGCVHFSYKASCEIRVLMLLYSSEKKIFIGLIPHDQGNFVNGIRRVIANQQQVLQRNLEQEQQQRGMGG
uniprot
proteins
function
FUNCTION: May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:15713644, ECO:0000269|PubMed:17641689}.
uniprot
proteins
mass_dalton
46869
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the CRL2(KLHDC2) complex, which recognizes the diglycine (Gly-Gly) at the C-terminus, leading to its degradation (PubMed:29779948). Ubiquitinated by the CRL2(APPBP2) complex, which recognizes the Arg-Xaa-Xaa-Gly sequence at the C-terminus, leading to its degradation (PubMed:29779948). {ECO:0000269|PubMed:29779948}.
uniprot
proteins
protein_family
Mediator complex subunit 25 family
uniprot
proteins
protein_family
PTOV1 subfamily
uniprot
proteins
pubmed
11313889
uniprot
proteins
pubmed
12598323
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14657022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
15713644
uniprot
proteins
pubmed
15778465
uniprot
proteins
pubmed
16639697
uniprot
proteins
pubmed
17641689
uniprot
proteins
pubmed
29779948
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:16639697}. Nucleus {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:15713644}. Cell membrane {ECO:0000269|PubMed:15713644}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11313889}. Note=Translocates from the cytoplasm to the nucleus at the onset of S-phase (PubMed:12598323). Also localizes to lipid rafts (PubMed:15713644). {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:15713644}.
uniprot
proteins