Il34
entrez
498951
canonical
uniprot
Q4KM46
canonical
ensembl
ENSRNOG00000017602
resolver
ensp
ENSRNOP00000023823
resolver
enst
ENSRNOT00000023823
resolver
genesymbol
Il34
resolver
uniprot
A0A140TAD0
resolver
uniprot_entry
A0A140TAD0_RAT
resolver
uniprot_entry
IL34_RAT
resolver
amino_acid_sequence
MPWGLAWLYCLGILLDVALGNENLEIWTLAQDKECDLTGYLRGKLQYKNRLQYMKHYFPINYRIAVPYEGVLRVANITRLKAHVSERELRYLWVLVSLNATESVLDVLLEGHPSWKYLQEVQTLLENVQRSLMDVEIGPHVEAVLSLLSTPGLSLKLVRPKALLDNCFRVMELLYCSCCKQSPILKWQDCELPRLHPHSPESLMQCAATNVYPLPRQPPTSLPRSPSSNHGPLP
uniprot
proteins
function
FUNCTION: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
26772
uniprot
proteins
protein_family
IL-34 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins