Q9QZX9
uniprot
Q9QZX9
canonical
amino_acid_sequence
MKYIAKKCGVRFQPPAMILIYENEAEGKSRQRIMPVRNFSKFSDCTRAAEQLKNNPRHKSYLEQVSLKQLEKLFVFLRGSLQGQSLAETMEQIQRETTIDPEEDLNKLDDKELAKRKSIMDELFEKNQKRKDDPSFVYDVEVEFPQDEQLQSCSWDTASVDEF
uniprot
proteins
function
FUNCTION: Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes. {ECO:0000250|UniProtKB:Q96LK0}.
uniprot
proteins
mass_dalton
19149
uniprot
proteins
protein_family
CEP19 family
uniprot
proteins
sequence_length
163
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q96LK0}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q96LK0}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q96LK0}. Note=Associates with the mother centriole in early interphase. Localizes to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase. Localizes slightly apical to the subdistal appendage on the mother centriole, but below the distal appendage. {ECO:0000250|UniProtKB:Q96LK0}.
uniprot
proteins