SLC47A1
entrez
55244
canonical
uniprot
Q96FL8
canonical
ensembl
ENSG00000142494
resolver
ensp
ENSP00000270570
resolver
genesymbol
SLC47A1
resolver
genesymbol_syn
MATE1
resolver
hgnc
HGNC:25588
resolver
uniprot
Q53HF5
resolver
uniprot
Q6PD77
resolver
uniprot
Q86VL4
resolver
uniprot
Q9NVA3
resolver
uniprot_entry
S47A1_HUMAN
resolver
uniprot_sec
Q53HF5
resolver
uniprot_sec
Q6PD77
resolver
uniprot_sec
Q86VL4
resolver
uniprot_sec
Q9NVA3
resolver
amino_acid_sequence
MEAPEEPAPVRGGPEATLEVRGSRCLRLSAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNVPRSGNSALPQDPLHPGCPENLEGILTNDVGKTGEPQSDQQMRQEEPLPEHPQDGAKLSRKQLVLRRGLLLLGVFLILLVGILVRFYVRIQ
uniprot
proteins
function
FUNCTION: Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:16330770, PubMed:17509534). Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373). Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373). May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17495125, ECO:0000269|PubMed:17509534, ECO:0000269|PubMed:17582384, ECO:0000269|PubMed:18305230, ECO:0000269|PubMed:19158817, ECO:0000269|PubMed:21128598, ECO:0000269|PubMed:24961373, ECO:0000305|PubMed:35307651}.
uniprot
proteins
mass_dalton
61922
uniprot
proteins
mutagenesis
MUTAGEN 273; /note="E->A: Abolishes membrane subcellular location. Abolishes TEA transport."; /evidence="ECO:0000269|PubMed:18305230"; MUTAGEN 273; /note="E->D: Does not affect membrane subcellular location. Decreases TEA transport. Higher affinity for cimetidine and reduced affinity to TEA."; /evidence="ECO:0000269|PubMed:18305230"; MUTAGEN 273; /note="E->Q: No change in subcellular location and abolition of MATE1-dependent TEA transport activity."; /evidence="ECO:0000269|PubMed:16330770"; MUTAGEN 278; /note="E->A: Does not affect membrane subcellular location. Abolishes TEA transport."; /evidence="ECO:0000269|PubMed:18305230"; MUTAGEN 278; /note="E->D: Does not affect membrane subcellular location. Decreases TEA transport."; /evidence="ECO:0000269|PubMed:18305230"; MUTAGEN 299; /note="Y->F: Decreased TEA and metformin uptake."; /evidence="ECO:0000269|PubMed:26979622"; MUTAGEN 300; /note="E->A,D: Does not affect membrane subcellular location. Decreases TEA transport."; /evidence="ECO:0000269|PubMed:18305230"; MUTAGEN 389; /note="E->A,D: Does not affect membrane subcellular location. Decreases TEA transport."; /evidence="ECO:0000269|PubMed:18305230
uniprot
proteins
protein_family
Multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16330770
uniprot
proteins
pubmed
16641166
uniprot
proteins
pubmed
16914559
uniprot
proteins
pubmed
17495125
uniprot
proteins
pubmed
17509534
uniprot
proteins
pubmed
17582384
uniprot
proteins
pubmed
18305230
uniprot
proteins
pubmed
19158817
uniprot
proteins
pubmed
21128598
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24961373
uniprot
proteins
pubmed
26979622
uniprot
proteins
pubmed
35307651
uniprot
proteins
sequence_length
570
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16641166, ECO:0000269|PubMed:18305230, ECO:0000269|PubMed:19158817}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:16330770}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the plasma membrane; at the brush border membranes of the proximal tubules (kidney) and at the bile caniculi (liver). {ECO:0000269|PubMed:16330770}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 73..93; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 124..144; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 153..173; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 257..276; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 296..316; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 337..357; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 371..391; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 409..429; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 438..458; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 547..567; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins