Pitpnb
entrez
114561
canonical
uniprot
P53812
canonical
ensembl
ENSRNOG00000000665
resolver
ensembl
ENSRNOG00055002527
resolver
ensembl
ENSRNOG00060004660
resolver
ensembl
ENSRNOG00065006086
resolver
ensp
ENSRNOP00000078649
resolver
genesymbol
Pitpnb
resolver
uniprot
Q6P7S3
resolver
uniprot_entry
PIPNB_RAT
resolver
uniprot_sec
Q6P7S3
resolver
activity_regulation
ACTIVITY REGULATION: Phosphatidylinositol transfer activity is inhibited by N-ethylmaleimide. {ECO:0000269|PubMed:18636990}.
uniprot
proteins
amino_acid_sequence
MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYENDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANTPDCPKMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNLHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKKGSVRGTSAADA
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of phosphatidylinositol between membranes (PubMed:18636990). Also catalyzes the transfer of phosphatidylcholine and sphingomyelin between membranes (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (By similarity). {ECO:0000250|UniProtKB:P48739, ECO:0000250|UniProtKB:Q9TR36, ECO:0000269|PubMed:18636990}.
uniprot
proteins
mass_dalton
31450
uniprot
proteins
mutagenesis
MUTAGEN 202..203; /note="WW->AA: Loss of Golgi membrane localization."; /evidence="ECO:0000269|PubMed:18636990
uniprot
proteins
post_translational_modification
PTM: Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting. {ECO:0000250|UniProtKB:P53811}.
uniprot
proteins
protein_family
PI transfer class I subfamily
uniprot
proteins
protein_family
PtdIns transfer protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18636990
uniprot
proteins
pubmed
7961615
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18636990}. Golgi apparatus membrane {ECO:0000269|PubMed:18636990}; Peripheral membrane protein {ECO:0000305|PubMed:18636990}; Cytoplasmic side {ECO:0000305|PubMed:18636990}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18636990}; Peripheral membrane protein {ECO:0000305|PubMed:18636990}; Cytoplasmic side {ECO:0000305|PubMed:18636990}. Golgi apparatus {ECO:0000250|UniProtKB:P53811}. Note=Primarily cytosolic in its closed conformation, it becomes enriched on Golgi and endoplasmic reticulum membranes in its open state, where it mediates lipid transfer. {ECO:0000269|PubMed:18636990}.
uniprot
proteins