Prkg2
entrez
25523
canonical
uniprot
Q64595
canonical
ensembl
ENSRNOG00000002361
resolver
ensembl
ENSRNOG00055006240
resolver
ensembl
ENSRNOG00060023270
resolver
ensembl
ENSRNOG00065018715
resolver
ensp
ENSRNOP00000003237
resolver
ensp
ENSRNOP00055007837
resolver
ensp
ENSRNOP00060033271
resolver
ensp
ENSRNOP00065025050
resolver
enst
ENSRNOT00000003237
resolver
enst
ENSRNOT00055010131
resolver
enst
ENSRNOT00060040299
resolver
enst
ENSRNOT00065031441
resolver
genesymbol
Prkg2
resolver
uniprot_entry
KGP2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Binding of cGMP results in enzyme activation. {ECO:0000305|PubMed:15872007}.
uniprot
proteins
amino_acid_sequence
MGNGSVKPKHSKHPDGQSGNLSNEALRSKVAELEREVKRKDAELQEREYHLKELREQLAKQTVAIAELTEELQSKCIQLNKLQDVIHVQGGSPLQASPDKVPLDVHRKTSGLVSLHSRRGAKAGVSAEPTSRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIVKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEEYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFDELQKYLEGYVATLNRDDEKRHAKRSMSSWKLSKALSLEMIQLKEKVARFSSTSPFQNLEIIATLGVGGFGRVELVKVKNENIAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYFDKYPPEKGVPPDEMSGWDKDF
uniprot
proteins
ec_number
2.7.11.12
uniprot
proteins
function
FUNCTION: Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane (PubMed:9465038). Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (Probable). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (PubMed:18031684). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). {ECO:0000250|UniProtKB:Q61410, ECO:0000269|PubMed:18031684, ECO:0000269|PubMed:9465038, ECO:0000305|PubMed:15872007}.
uniprot
proteins
mass_dalton
87182
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Cytosolic localization."; /evidence="ECO:0000269|PubMed:9465038
uniprot
proteins
post_translational_modification
PTM: Myristoylation mediates membrane localization. {ECO:0000250}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
cGMP subfamily
uniprot
proteins
pubmed
15872007
uniprot
proteins
pubmed
18031684
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
25070890
uniprot
proteins
pubmed
7937783
uniprot
proteins
pubmed
9465038
uniprot
proteins
sequence_length
762
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q13237}; Lipid-anchor {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:9465038}; Lipid-anchor {ECO:0000305|PubMed:9465038}. Note=Plasma membrane localization is required for its function in the activation of CFTR. {ECO:0000269|PubMed:9465038}.
uniprot
proteins