ALKBH4
entrez
54784
canonical
uniprot
Q9NXW9
canonical
ensembl
ENSG00000160993
resolver
ensp
ENSP00000292566
resolver
genesymbol
ALKBH4
resolver
genesymbol_syn
ABH4
resolver
hgnc
HGNC:21900
resolver
uniprot
Q53H92
resolver
uniprot
Q9H6A4
resolver
uniprot_entry
ALKB4_HUMAN
resolver
uniprot_sec
Q53H92
resolver
uniprot_sec
Q9H6A4
resolver
amino_acid_sequence
MAAAAAETPEVLRECGCKGIRTCLICERQRGSDPPWELPPAKTYRFIYCSDTGWAVGTEESDFEGWAFPFPGVMLIEDFVTREEEAELVRLMDRDPWKLSQSGRRKQDYGPKVNFRKQKLKTEGFCGLPSFSREVVRRMGLYPGLEGFRPVEQCNLDYCPERGSAIDPHLDDAWLWGERLVSLNLLSPTVLSMCREAPGSLLLCSAPSAAPEALVDSVIAPSRSVLCQEVEVAIPLPARSLLVLTGAARHQWKHAIHRRHIEARRVCVTFRELSAEFGPGGRQQELGQELLRIALSFQGRPV
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
ec_number
1.14.11.51
uniprot
proteins
function
FUNCTION: Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (PubMed:23673617). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (By similarity). {ECO:0000250|UniProtKB:Q9D8F1, ECO:0000269|PubMed:23673617}.
uniprot
proteins
mass_dalton
33838
uniprot
proteins
mutagenesis
MUTAGEN 169; /note="H->A: Loss of function mutant that acts as a dominant-negative mutant when overexpressed, leading to multinucleation and cleavage furrow disorganization; when associated with A-171 and A-254."; /evidence="ECO:0000269|PubMed:23673617"; MUTAGEN 171; /note="D->A: Loss of function mutant that acts as a dominant-negative mutant when overexpressed, leading to multinucleation and cleavage furrow disorganization; when associated with A-169 and A-254."; /evidence="ECO:0000269|PubMed:23673617"; MUTAGEN 254; /note="H->A: Loss of function mutant that acts as a dominant-negative mutant when overexpressed, leading to multinucleation and cleavage furrow disorganization; when associated with A-169 and A-171."; /evidence="ECO:0000269|PubMed:23673617
uniprot
proteins
protein_family
AlkB family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17979886
uniprot
proteins
pubmed
21166655
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23145062
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23673617
uniprot
proteins
sequence_length
302
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17979886}. Nucleus {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:23145062}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9D8F1}. Midbody {ECO:0000269|PubMed:23673617}. Note=Associates with the contractile ring and midbody. {ECO:0000269|PubMed:23673617}.
uniprot
proteins