DHRS7
entrez
51635
canonical
uniprot
Q9Y394
canonical
ensembl
ENSG00000100612
resolver
ensp
ENSP00000442993
resolver
ensp
ENSP00000451882
resolver
genesymbol
DHRS7
resolver
genesymbol_syn
DHRS7A
resolver
genesymbol_syn
RETSDR4
resolver
genesymbol_syn
SDR34C1
resolver
hgnc
HGNC:21524
resolver
uniprot
B2R896
resolver
uniprot
Q9UKU2
resolver
uniprot_entry
DHRS7_HUMAN
resolver
uniprot_sec
B2R896
resolver
uniprot_sec
Q9UKU2
resolver
amino_acid_sequence
MNWELLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPVQSNIVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQYMPTWAWWITNKMGKKRIENFKSGVDADSSYFKIFKTKHD
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
function
FUNCTION: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics (PubMed:24246760, PubMed:26466768, PubMed:28457967, PubMed:28687384). Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function (PubMed:28457967, PubMed:28687384). Involved in the reduction of all-trans-retinal to all-trans-retinol (PubMed:26466768). Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable (PubMed:28457967). Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group (PubMed:24246760, PubMed:26466768). A dehydrogenase activity has not been detected so far (PubMed:24246760). May play a role as tumor suppressor (PubMed:26311046). {ECO:0000269|PubMed:24246760, ECO:0000269|PubMed:26311046, ECO:0000269|PubMed:26466768, ECO:0000269|PubMed:28457967, ECO:0000269|PubMed:28687384}.
uniprot
proteins
mass_dalton
38299
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
10800688
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19027726
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24246760
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26311046
uniprot
proteins
pubmed
26466768
uniprot
proteins
pubmed
28457967
uniprot
proteins
pubmed
28687384
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24246760, ECO:0000269|PubMed:28457967}. Note=Bound to the endoplasmic reticulum membrane, possibly through a N-terminus anchor. The main bulk of the polypeptide chain was first reported to be facing toward the lumen of the endoplasmic reticulum (PubMed:24246760). However, it was later shown to be facing the cytosol (PubMed:28457967). {ECO:0000269|PubMed:24246760, ECO:0000269|PubMed:28457967}.
uniprot
proteins