Slc12a7
entrez
20499
canonical
uniprot
Q9WVL3
canonical
ensembl
ENSMUSG00000017756
resolver
ensp
ENSMUSP00000017900
resolver
ensp
ENSMUSP00000160251
resolver
ensp
ENSMUSP00000241013
resolver
genesymbol
Slc12a7
resolver
genesymbol_syn
Kcc4
resolver
uniprot
B9EIV8
resolver
uniprot
Q3TB23
resolver
uniprot
Q3TDX1
resolver
uniprot
Q3UE50
resolver
uniprot
Q6KAS8
resolver
uniprot_entry
B9EIV8_MOUSE
resolver
uniprot_entry
S12A7_MOUSE
resolver
uniprot_sec
Q3TB23
resolver
uniprot_sec
Q3TDX1
resolver
uniprot_sec
Q3UE50
resolver
uniprot_sec
Q6KAS8
resolver
activity_regulation
ACTIVITY REGULATION: Activated by N-ethylmaleimide (NEM). Inhibited by furosemide, DIDS and bumetanide. The inhibition is much stronger in the presence of 50 mM K(+) in the uptake medium. Inhibited by DIOA. Inhibited by WNK3. {ECO:0000250|UniProtKB:Q9Y666}.
uniprot
proteins
amino_acid_sequence
MPTNFTVVPVEARADGAGDEAAERTEEPESPESVDQTSPTPGDGNPRENSPFINNVEVERESYFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEDSRRREVKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVMESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPSAAIFQAETADGEAAALLNNMRVYGSCALALMAVVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFAPPDIPVCLLGNRTLANRNFDTCAKMQVVSNGTVTTALWRLFCNGSSLGATCDEYFAQNNVTEIQGIPGVASGVFLDNLWSTYSDKGAFVEKKGVSSVPVSEESRPGGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIIPFLQVFGHGKANGEPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALFAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDSEQCVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHVEAQRAEENIRSLMSAEKTKGFCQLVVSSNLRDGASHLIQSAGLGGMKHNTVLMAWPEAWKEADNPFSWKNFVDTVRDTTAAHQALLVAKNIDLFPQNQERFSDGNIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYEKTLMMEQRSQMLKQMQLSKNEREREAQLIHDRNTASHTTATARTQAPPTPDKVQMTWTKEKLIAEKHRNKDTGPSGFKDLFSLKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKSRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Slc12a7 are a cause of deafness due to the progressive degeneration of outer and inner hair cells in the cochlea and of neurons in the cochlear ganglion, leading to the loss of the organ of Corti. {ECO:0000269|PubMed:11976689}.
uniprot
proteins
function
FUNCTION: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:11551954, PubMed:12106695). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti (PubMed:11976689). May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (Probable). {ECO:0000269|PubMed:11551954, ECO:0000269|PubMed:11976689, ECO:0000269|PubMed:12106695, ECO:0000305}.
uniprot
proteins
mass_dalton
119481
uniprot
proteins
post_translational_modification
PTM: Glycosylation at Asn-331 and Asn-344 is required for proper trafficking to the cell surface, and augments protein stability. {ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:19656770, ECO:0000269|PubMed:23376777}.
uniprot
proteins
protein_family
K/Cl co-transporter subfamily
uniprot
proteins
protein_family
SLC12A transporter family
uniprot
proteins
pubmed
10347194
uniprot
proteins
pubmed
11551954
uniprot
proteins
pubmed
11976689
uniprot
proteins
pubmed
12106695
uniprot
proteins
pubmed
15449545
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23376777
uniprot
proteins
sequence_length
1083
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23376777}; Multi-pass membrane protein {ECO:0000269|PubMed:23376777}.
uniprot
proteins
transmembrane_region
TRANSMEM 120..142; /note="Discontinuously helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 150..172; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 197..225; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 250..271; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 272..300; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 420..440; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 451..473; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 505..531; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 555..573; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 574..598; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 613..635; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 636..651; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q9Y666
uniprot
proteins