MED28
entrez
80306
canonical
uniprot
Q9H204
canonical
ensembl
ENSG00000118579
resolver
ensp
ENSP00000237380
resolver
enst
ENST00000237380
resolver
genesymbol
MED28
resolver
genesymbol_syn
EG1
resolver
hgnc
HGNC:24628
resolver
uniprot
Q9BZJ5
resolver
uniprot_entry
MED28_HUMAN
resolver
uniprot_sec
Q9BZJ5
resolver
amino_acid_sequence
MAAPLGGMFSGQPPGPPQAPPGLPGQASLLQAAPGAPRPSSSTLVDELESSFEACFASLVSQDYVNGTDQEEIRTGVDQCIQKFLDIARQTECFFLQKRLQLSVQKPEQVIKEDVSELRNELQRKDALVQKHLTKLRHWQQVLEDINVQHKKPADIPQGSLAYLEQASANIPAPLKPT
uniprot
proteins
function
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. {ECO:0000269|PubMed:15467741}.
uniprot
proteins
mass_dalton
19520
uniprot
proteins
protein_family
Mediator complex subunit 28 family
uniprot
proteins
pubmed
11779215
uniprot
proteins
pubmed
15175163
uniprot
proteins
pubmed
15467741
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15989967
uniprot
proteins
pubmed
21269460
uniprot
proteins
sequence_length
178
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15467741}. Cytoplasm {ECO:0000269|PubMed:15467741}. Membrane {ECO:0000269|PubMed:15467741}; Peripheral membrane protein {ECO:0000269|PubMed:15467741}. Note=According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated.
uniprot
proteins