SSX2IP
entrez
117178
canonical
uniprot
Q9Y2D8
canonical
ensembl
ENSG00000117155
resolver
ensp
ENSP00000340279
resolver
ensp
ENSP00000412781
resolver
ensp
ENSP00000474480
resolver
ensp
ENSP00000474925
resolver
ensp
ENSP00000539215
resolver
ensp
ENSP00000539216
resolver
ensp
ENSP00000539218
resolver
ensp
ENSP00000539220
resolver
ensp
ENSP00000539222
resolver
ensp
ENSP00000539223
resolver
ensp
ENSP00000539225
resolver
ensp
ENSP00000539226
resolver
ensp
ENSP00000587205
resolver
ensp
ENSP00000587206
resolver
ensp
ENSP00000671162
resolver
ensp
ENSP00000700666
resolver
ensp
ENSP00000700667
resolver
ensp
ENSP00000700669
resolver
genesymbol
SSX2IP
resolver
genesymbol_syn
KIAA0923
resolver
hgnc
HGNC:16509
resolver
uniprot
A8K8W0
resolver
uniprot
B4DFE3
resolver
uniprot
B7ZB07
resolver
uniprot
D3DT13
resolver
uniprot
J3KR02
resolver
uniprot
Q6P2P8
resolver
uniprot
Q6ULS1
resolver
uniprot
Q7L168
resolver
uniprot
Q9UIX0
resolver
uniprot_entry
ADIP_HUMAN
resolver
uniprot_entry
B7ZB07_HUMAN
resolver
uniprot_sec
A8K8W0
resolver
uniprot_sec
B4DFE3
resolver
uniprot_sec
D3DT13
resolver
uniprot_sec
J3KR02
resolver
uniprot_sec
Q6P2P8
resolver
uniprot_sec
Q6ULS1
resolver
uniprot_sec
Q7L168
resolver
uniprot_sec
Q9UIX0
resolver
amino_acid_sequence
MGDWMTVTDPGLSSESKTISQYTSETKMSPSSLYSQQVLCSSIPLSKNVHSFFSAFCTEDNIEQSISYLDQELTTFGFPSLYEESKGKETKRELNIVAVLNCMNELLVLQRKNLLAQENVETQNLKLGSDMDHLQSCYSKLKEQLETSRREMIGLQERDRQLQCKNRNLHQLLKNEKDEVQKLQNIIASRATQYNHDMKRKEREYNKLKERLHQLVMNKKDKKIAMDILNYVGRADGKRGSWRTGKTEARNEDEMYKILLNDYEYRQKQILMENAELKKVLQQMKKEMISLLSPQKKKPRERVDDSTGTVISDVEEDAGELSRESMWDLSCETVREQLTNSIRKQWRILKSHVEKLDNQVSKVHLEGFNDEDVISRQDHEQETEKLELEIQQCKEMIKTQQQLLQQQLATAYDDDTTSLLRDCYLLEEKERLKEEWSLFKEQKKNFERERRSFTEAAIRLGLERKAFEEERASWLKQQFLNMTTFDHQNSENVKLFSAFSGSSDWDNLIVHSRQPQKKPHSVSNGSPVCMSKLTKSLPASPSTSDFCQTRSCISEHSSINVLNITAEEIKPNQVGGECTNQKWSVASRPGSQEGCYSGCSLSYTNSHVEKDDLP
uniprot
proteins
function
FUNCTION: Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449, ECO:0000305|PubMed:26545777}.
uniprot
proteins
mass_dalton
71236
uniprot
proteins
protein_family
ADIP family
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
12007189
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17686061
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19179477
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23816619
uniprot
proteins
pubmed
23826132
uniprot
proteins
pubmed
24356449
uniprot
proteins
pubmed
26545777
uniprot
proteins
sequence_length
614
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24356449}. Note=Not found at cell-matrix AJs. {ECO:0000250}.
uniprot
proteins