NCS1
entrez
23413
canonical
uniprot
P62166
canonical
ensembl
ENSG00000107130
resolver
ensp
ENSP00000361475
resolver
ensp
ENSP00000486695
resolver
genesymbol
NCS1
resolver
genesymbol_syn
FLUP
resolver
genesymbol_syn
FREQ
resolver
hgnc
HGNC:3953
resolver
uniprot
E9PAY3
resolver
uniprot
P36610
resolver
uniprot
Q9UK26
resolver
uniprot_entry
NCS1_HUMAN
resolver
uniprot_sec
E9PAY3
resolver
uniprot_sec
P36610
resolver
uniprot_sec
Q9UK26
resolver
amino_acid_sequence
MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDGLV
uniprot
proteins
function
FUNCTION: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
21879
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: No effect on interaction with RIC8A."; /evidence="ECO:0000269|PubMed:28119500"; MUTAGEN 81; /note="E->T: Reduces calcium binding; when associated with A-117 or A-165. Abolishes calcium binding; when associated with A-117 and A-165."; /evidence="ECO:0000269|PubMed:11092894"; MUTAGEN 117; /note="T->A: Reduces calcium binding; when associated with T-81. Abolishes calcium binding; when associated with T-81 and A-165."; /evidence="ECO:0000269|PubMed:11092894"; MUTAGEN 165; /note="T->A: Reduces calcium binding; when associated with A-117. Abolishes calcium binding; when associated with T-81 and A-117."; /evidence="ECO:0000269|PubMed:11092894
uniprot
proteins
protein_family
Recoverin family
uniprot
proteins
pubmed
11092894
uniprot
proteins
pubmed
11606724
uniprot
proteins
pubmed
12783849
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17555535
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25074811
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
28119500
uniprot
proteins
pubmed
29966094
uniprot
proteins
sequence_length
190
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:17555535}. Postsynaptic density {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11092894, ECO:0000269|PubMed:17555535}. Cytoplasm {ECO:0000250|UniProtKB:P62168}. Cell membrane {ECO:0000269|PubMed:17555535}; Peripheral membrane protein. Membrane {ECO:0000250|UniProtKB:P62168}; Lipid-anchor {ECO:0000305}. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions. {ECO:0000305, ECO:0000305|PubMed:17555535}.
uniprot
proteins