HNRNPD
entrez
3184
canonical
uniprot
Q14103
canonical
ensembl
ENSG00000138668
resolver
ensp
ENSP00000305860
resolver
ensp
ENSP00000313199
resolver
ensp
ENSP00000313327
resolver
ensp
ENSP00000564898
resolver
genesymbol
HNRNPD
resolver
genesymbol_syn
AUF1
resolver
genesymbol_syn
HNRPD
resolver
hgnc
HGNC:5036
resolver
uniprot
A8K9J2
resolver
uniprot
P07029
resolver
uniprot
Q01858
resolver
uniprot
Q14100
resolver
uniprot
Q14101
resolver
uniprot
Q14102
resolver
uniprot
Q4W5A1
resolver
uniprot
Q9UCE8
resolver
uniprot
Q9UCE9
resolver
uniprot_entry
HNRPD_HUMAN
resolver
uniprot_sec
A8K9J2
resolver
uniprot_sec
P07029
resolver
uniprot_sec
Q01858
resolver
uniprot_sec
Q14100
resolver
uniprot_sec
Q14101
resolver
uniprot_sec
Q14102
resolver
uniprot_sec
Q4W5A1
resolver
uniprot_sec
Q9UCE8
resolver
uniprot_sec
Q9UCE9
resolver
amino_acid_sequence
MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAATQGAAAAAGSGAGTGGGTASGGTEGGSAESEGAKIDASKNEEDEGHSNSSPRHSEAATAQREEWKMFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIMEKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGGGPSQNWNQGYSNYWNQGYGNYGYNSQGYGGYGGYDYTGYNNYYGYGDYSNQQSGYGKVSRRGGHQNSYKPY
uniprot
proteins
function
FUNCTION: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. {ECO:0000269|PubMed:10080887, ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:24423872}.
uniprot
proteins
mass_dalton
38434
uniprot
proteins
post_translational_modification
PTM: Arg-345 is dimethylated, probably to asymmetric dimethylarginine.; PTM: Methylated by PRMT1, in an insulin-dependent manner. The PRMT1-mediated methylation regulates tyrosine phosphorylation (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
10024518
uniprot
proteins
pubmed
10080887
uniprot
proteins
pubmed
11051545
uniprot
proteins
pubmed
12674497
uniprot
proteins
pubmed
1433497
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15782174
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17289661
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21515746
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24423872
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
3754960
uniprot
proteins
pubmed
7673195
uniprot
proteins
pubmed
8321232
uniprot
proteins
pubmed
9521873
uniprot
proteins
pubmed
9615222
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally.
uniprot
proteins