Ccl21a
entrez
18829
canonical
uniprot
P84444
canonical
ensembl
ENSMUSG00000094686
resolver
ensp
ENSMUSP00000092732
resolver
enst
ENSMUST00000095114
resolver
genesymbol
Ccl21a
resolver
genesymbol_syn
Scya21
resolver
genesymbol_syn
Scya21a
resolver
uniprot
O09002
resolver
uniprot
O09006
resolver
uniprot
Q3U1J2
resolver
uniprot
Q91V84
resolver
uniprot_entry
CC21A_MOUSE
resolver
uniprot_sec
O09002
resolver
uniprot_sec
O09006
resolver
uniprot_sec
Q3U1J2
resolver
uniprot_sec
Q91V84
resolver
amino_acid_sequence
MAQMMTLSLLSLVLALCIPWTQGSDGGGQDCCLKYSQKKIPYSIVRGYRKQEPSLGCPIPAILFSPRKHSKPELCANPEEGWVQNLMRRLDQPPAPGKQSPGCRKNRGTSKSGKKGKGSKGCKRTEQTQPSRG
uniprot
proteins
disease_involvement
DISEASE: Note=Mice carrying an autosomal recessive mutation designated paucity of lymph node T-cells (plt) show dramatically reduced numbers of T-cells in lymph nodes, Peyer patches, and the white pulp of the spleen. Plt seems to correspond to Scya21b. {ECO:0000269|PubMed:10523616}.
uniprot
proteins
function
FUNCTION: Binds to chemokine receptors CCR7 and CXCR3. Also binds to G protein-coupled receptor GPR174 (PubMed:31875850). Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. {ECO:0000269|PubMed:31875850}.
uniprot
proteins
mass_dalton
14558
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
10523616
uniprot
proteins
pubmed
11123313
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
31875850
uniprot
proteins
pubmed
9257816
uniprot
proteins
pubmed
9419363
uniprot
proteins
pubmed
9548511
uniprot
proteins
sequence_length
133
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins