Rabac1
entrez
83583
canonical
uniprot
O35394
canonical
ensembl
ENSRNOG00000020233
resolver
ensembl
ENSRNOG00055033184
resolver
ensembl
ENSRNOG00060029402
resolver
ensembl
ENSRNOG00065031562
resolver
ensp
ENSRNOP00000027435
resolver
ensp
ENSRNOP00055047300
resolver
ensp
ENSRNOP00060042465
resolver
ensp
ENSRNOP00065044763
resolver
enst
ENSRNOT00000027435
resolver
enst
ENSRNOT00055057365
resolver
enst
ENSRNOT00060051045
resolver
enst
ENSRNOT00065054396
resolver
genesymbol
Rabac1
resolver
genesymbol_syn
Pra1
resolver
genesymbol_syn
Praf1
resolver
uniprot_entry
PRAF1_RAT
resolver
amino_acid_sequence
MAAQKDQQKDAEVEGLSATTLLPKLIPSGAGREWLERRRATIRPWGTFVDQQRFSRPRNVGELCQRLVRNVEYYQSNYVFVFLGLILYCVVTSPMLLVALAVFFGACYILYLRTLQSKLVLFGREVSPAHQYALAGGVSFPFFWLAGAGSAVFWVLGATLVLIGSHAAFHQIEPADGEELQMEPV
uniprot
proteins
function
FUNCTION: General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI1. {ECO:0000269|PubMed:10751420, ECO:0000269|PubMed:12107180, ECO:0000269|PubMed:9341137}.
uniprot
proteins
mass_dalton
20643
uniprot
proteins
mutagenesis
MUTAGEN 70; /note="N->T: Retained in endoplasmic reticulum, no interaction with RAB3A or VAMP2."; /evidence="ECO:0000269|PubMed:12107180"; MUTAGEN 73; /note="Y->A: Retained in endoplasmic reticulum, Golgi and tubular structures, no interaction with RAB3A."; /evidence="ECO:0000269|PubMed:12107180"; MUTAGEN 76; /note="S->A,V: Increased interaction with RAB3A or VAMP2, Golgi condensation."; /evidence="ECO:0000269|PubMed:12107180"; MUTAGEN 77; /note="N->A: No effect."; /evidence="ECO:0000269|PubMed:12107180"; MUTAGEN 78; /note="Y->A: Retained in endoplasmic reticulum, no interaction with RAB3A or VAMP2."; /evidence="ECO:0000269|PubMed:12107180"; MUTAGEN 154; /note="W->A: No effect."; /evidence="ECO:0000269|PubMed:12107180"; MUTAGEN 161; /note="V->A: Increased interaction with RAB3A or VAMP2, Golgi condensation."; /evidence="ECO:0000269|PubMed:12107180"; MUTAGEN 166; /note="H->A: Retained in endoplasmic reticulum, Golgi and tubular structures, no interaction with RAB3A."; /evidence="ECO:0000269|PubMed:12107180"; MUTAGEN 176; /note="D->A: Retained in endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:11096102"; MUTAGEN 178; /note="E->A: Retained in endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:11096102"; MUTAGEN 179; /note="E->A: Retained in endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:11096102
uniprot
proteins
protein_family
PRA1 family
uniprot
proteins
pubmed
10707984
uniprot
proteins
pubmed
10751420
uniprot
proteins
pubmed
11096102
uniprot
proteins
pubmed
12107180
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9341137
uniprot
proteins
sequence_length
185
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10751420}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:10751420}. Golgi apparatus {ECO:0000269|PubMed:10751420, ECO:0000269|PubMed:11096102, ECO:0000269|PubMed:12107180}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:10707984}. Note=According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associated to Golgi (PubMed:10751420, PubMed:12107180, PubMed:11096102) and synaptic vesicles (PubMed:10707984). {ECO:0000269|PubMed:10707984, ECO:0000269|PubMed:10751420, ECO:0000269|PubMed:11096102, ECO:0000269|PubMed:12107180}.
uniprot
proteins
transmembrane_region
TRANSMEM 79..94; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 95..112; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 132..148; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 149..165; /note="Helical"; /evidence="ECO:0000250
uniprot
proteins