Ano2
entrez
243634
canonical
uniprot
Q8CFW1
canonical
ensembl
ENSMUSG00000038115
resolver
ensp
ENSMUSP00000125303
resolver
ensp
ENSMUSP00000302916
resolver
enst
ENSMUST00000160496
resolver
genesymbol
Ano2
resolver
genesymbol_syn
Tmem16b
resolver
uniprot
C4N788
resolver
uniprot
M1GRW0
resolver
uniprot
M1H0B0
resolver
uniprot
Q8C8N6
resolver
uniprot_entry
ANO2_MOUSE
resolver
uniprot_entry
M1GRW0_MOUSE
resolver
uniprot_entry
M1H0B0_MOUSE
resolver
uniprot_sec
C4N788
resolver
uniprot_sec
Q8C8N6
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is repressed by chloride inhibitors; strongly by niflumic acid (NFA), partially by flufenamic acid (FFA), and only slightly by meclofenamic acid (MFA), 5-Nitro-2-(3-phenylpropylamino)benzoic acid (NPPB), 4-acetamido-4'-isothiocyanato-stilben-2,2'-disulfonate (SITS), and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS). {ECO:0000269|PubMed:19475416}.
uniprot
proteins
amino_acid_sequence
MAAPGLRDIPLLPGSPRRLSSRTVARGSQGPKHGQQYLKVPGHRAPGQRDNSSLHPSQVSRRESSRDRSVINNYLDANEPPSSEARLSRMHFHDNQRKVDYVLAYHYRKRGAHLGHGSPGHSLAVISNGETGKERHGGGPGDVELGPLDALEEERREQRDEFEHNLMAAGLELEKDLESKSQGSVFVRIHAPWQVLAREAEFLKIKVPTKKMYEIKAGGSIAKKFSAILQTLSSPLQPRVPEHSNNRMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPGDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSKEMCDHQNAFTMCPLCDKSCDYWNLSSACGTARASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERSQEHSRPEYETKVREKLLKESGKSAVQKLEANSPEDDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEPGESDPDHSKRPEQWDLDHSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVIINAFVIAVTSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWSVLSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKVKLADEPTQRSQGGGDRSRRSRAASSAPSGRSQPGSIASSGSQHTNV
uniprot
proteins
function
FUNCTION: Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. {ECO:0000269|PubMed:19474308, ECO:0000269|PubMed:19475416, ECO:0000269|PubMed:19561302, ECO:0000269|PubMed:22075693}.
uniprot
proteins
mass_dalton
114134
uniprot
proteins
mutagenesis
MUTAGEN 1000..1002; /note="Missing: Impaired interaction with DLG4."; /evidence="ECO:0000269|PubMed:19474308
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:19474308}.
uniprot
proteins
protein_family
Anoctamin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18729231
uniprot
proteins
pubmed
19474308
uniprot
proteins
pubmed
19475416
uniprot
proteins
pubmed
19561302
uniprot
proteins
pubmed
20056604
uniprot
proteins
pubmed
22075693
uniprot
proteins
pubmed
23576756
uniprot
proteins
sequence_length
1002
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19474308, ECO:0000269|PubMed:19561302}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 365..385; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 434..454; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 537..557; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 581..601; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 622..642; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 747..767; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 800..820; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 906..926; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins