Impact
entrez
16210
canonical
uniprot
O55091
canonical
ensembl
ENSMUSG00000024423
resolver
ensp
ENSMUSP00000025290
resolver
enst
ENSMUST00000025290
resolver
genesymbol
Impact
resolver
uniprot
Q3UUR6
resolver
uniprot
Q9EQH0
resolver
uniprot_entry
IMPCT_MOUSE
resolver
uniprot_sec
Q3UUR6
resolver
uniprot_sec
Q9EQH0
resolver
amino_acid_sequence
MAEEEVGNSQRQSEEIEAMAAIYGEEWCVIDENAKIFCIRVTDFMDDPKWTLCLQVMLPSEYPGTAPPSYQLNAPWLKGQERADLSNSLEEIYVHNMGESILYQWVEKIRDALIQKSQITEPDPDVKKKTEEVEVESEEDPILEHPPENPVKTLDLKISEETQPETEELPPVAHGVPITDRRSTFQAHVAPVVCPEQVKLVLAKLYENKKIASATHNIYAYRIFCEDKQTFLQDCEDDGETAAGGRLLHLMEILNVKNVMVVVSRWYGGILLGPDRFKHINNCARNILVEKNFTNTPDESTKNLGKKKVKKDKKKNDH
uniprot
proteins
function
FUNCTION: Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis (PubMed:15937339, PubMed:23447528, PubMed:24333428). May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis (PubMed:15937339, PubMed:23447528). Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth (PubMed:23447528). {ECO:0000269|PubMed:15937339, ECO:0000269|PubMed:23447528, ECO:0000269|PubMed:24333428}.
uniprot
proteins
mass_dalton
36276
uniprot
proteins
protein_family
IMPACT family
uniprot
proteins
pubmed
11116084
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15871461
uniprot
proteins
pubmed
15937339
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18260151
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22404850
uniprot
proteins
pubmed
23447528
uniprot
proteins
pubmed
24333428
uniprot
proteins
pubmed
9256468
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:23447528}.
uniprot
proteins