Tgfbr3
entrez
21814
canonical
uniprot
O88393
canonical
ensembl
ENSMUSG00000029287
resolver
ensp
ENSMUSP00000031224
resolver
enst
ENSMUST00000031224
resolver
genesymbol
Tgfbr3
resolver
uniprot
A0A0R4J097
resolver
uniprot
Q6NS72
resolver
uniprot_entry
A0A0R4J097_MOUSE
resolver
uniprot_entry
TGBR3_MOUSE
resolver
uniprot_sec
Q6NS72
resolver
amino_acid_sequence
MAVTSHHMVPVFVLMSACLATAGPEPSTRCELSPISASHPVQALMESFTVLSGCASRGTTGLPREVHILNLRSTDQGLGQPQREVTLHLNPIASVHTHHKPVVFLLNSPQPLVWHVKTERLAAGVPRLFLVSEGSVVQFSSGNFSLTAETEERSFPQENEHLLHWAQKEYGAVTSFTELKIARNIYIKVGEDQVFPPTCNIGKNFLSLNYLAEYLQPKAAEGCVLASQPHEKEVHIIELISPNSNPYSTFQVDIIIDIRPAREDPEVVKNLVLILKCKKSVNWVIKSFDVKGNLKVIAPDSIGFGKESERSMTVTKLVRNDYPSTQENLMKWALDNGYSPVTSYTIAPVANRFHLRLENNEEMRDEEVHTIPPELRILLGPDHLPALDSPPFQGEIPNGGFPFPFPDIPRRGWKEGEDRIPRPKEPIIPRVQLLPDHREPEEVQGGVNIALSVKCDNEKMVVAVDKDSFQTNGYSGMELTLLDPSCKAKMNGTHFVLESPLNGCGTRHRRSAPDGVVYYNSIVVQAPSPGDSSGWPDGYEDLESGDNGFPGDTDEGETAPLSRAGVVVFNCSLRQLRSPSGFQDQLDGNATFNMELYNTDLFLVPSPGVFSVAENEHVYVEVSVTKADQDLGFAIQTCFISPYSNPDRMSDYTIIENICPKDDSVKFYSSKRVHFPIPHAEVDKKRFSFVFKSVFNTSLLFLHCELTLCSRNKGSQKLPKCVTPDDACTSLDATMIWTMMQNKKTFTKPLAVVLQVDYKENVPNMKESSPVPPPPQIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETARRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA
uniprot
proteins
function
FUNCTION: Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5. Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B (By similarity). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (PubMed:30364975, PubMed:34910520). Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization (By similarity). Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway (By similarity). {ECO:0000250|UniProtKB:P26342, ECO:0000269|PubMed:30364975, ECO:0000269|PubMed:34910520}.
uniprot
proteins
mass_dalton
93829
uniprot
proteins
mutagenesis
MUTAGEN 533; /note="S->A: Loss of glycosaminoglycan chains; when associated with A-544."; /evidence="ECO:0000269|PubMed:9659379"; MUTAGEN 544; /note="S->A: Loss of glycosaminoglycan chains; when associated with A-533."; /evidence="ECO:0000269|PubMed:9659379
uniprot
proteins
post_translational_modification
PTM: Extensively modified by glycosaminoglycan groups (GAG). {ECO:0000250|UniProtKB:Q03167}.; PTM: Phosphorylated in the cytoplasmic domain by the type II receptor TGFBR2 at THR-839 to mediate recruitment of ARRB2 and subsequent internalization of TGFBR2 and TGFBR3. {ECO:0000250|UniProtKB:Q03167}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17704211
uniprot
proteins
pubmed
21871877
uniprot
proteins
pubmed
22033038
uniprot
proteins
pubmed
23826237
uniprot
proteins
pubmed
30364975
uniprot
proteins
pubmed
34910520
uniprot
proteins
pubmed
9659379
uniprot
proteins
sequence_length
850
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P26342}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:P26342}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P26342}. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix. {ECO:0000250|UniProtKB:P26342}.
uniprot
proteins
transmembrane_region
TRANSMEM 786..808; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins