Tmem106a
entrez
287722
canonical
uniprot
Q5BK83
canonical
ensembl
ENSRNOG00000023628
resolver
ensembl
ENSRNOG00055033328
resolver
ensembl
ENSRNOG00060013860
resolver
ensembl
ENSRNOG00065031923
resolver
ensp
ENSRNOP00000036228
resolver
ensp
ENSRNOP00055047512
resolver
ensp
ENSRNOP00060018841
resolver
ensp
ENSRNOP00065045235
resolver
enst
ENSRNOT00000035523
resolver
enst
ENSRNOT00055057620
resolver
enst
ENSRNOT00060023689
resolver
enst
ENSRNOT00065054996
resolver
genesymbol
Tmem106a
resolver
uniprot
A0A8L2UL38
resolver
uniprot_entry
A0A8L2UL38_RAT
resolver
uniprot_entry
T106A_RAT
resolver
amino_acid_sequence
MGKAFSQLTSQKDEDKSILPDNPAMASKAANYFSTGNRKPSHSCVPCEKAASTSFVTCPTCQGNGEIPQELEKQLVALIPYGDQRLKPRRTKLSVFLAVTICLLIFSLTIFFLYPRNIVVHPVGLNSSTVAFDETHVQLNMTNVLNITNSNFYPVTVTQLTAEVLHQTSVVGQVTSSLRLHIGPLASKQMPYEVASRILDENTYKICTWPKIRVHHILVNIQGALTCSYLTHPQQLPFESFEYVDCRENMSMPHLELPRPA
uniprot
proteins
function
FUNCTION: Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (By similarity). {ECO:0000250|UniProtKB:Q8VC04, ECO:0000250|UniProtKB:Q96A25}.
uniprot
proteins
mass_dalton
29136
uniprot
proteins
protein_family
TMEM106 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8VC04}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins