EFNB3
entrez
1949
canonical
uniprot
Q15768
canonical
ensembl
ENSG00000108947
resolver
ensp
ENSP00000226091
resolver
enst
ENST00000226091
resolver
genesymbol
EFNB3
resolver
genesymbol_syn
EPLG8
resolver
genesymbol_syn
LERK8
resolver
hgnc
HGNC:3228
resolver
uniprot
B2RBW2
resolver
uniprot
D3DTQ6
resolver
uniprot
O00680
resolver
uniprot
Q8TBH7
resolver
uniprot
Q92875
resolver
uniprot_entry
EFNB3_HUMAN
resolver
uniprot_sec
B2RBW2
resolver
uniprot_sec
D3DTQ6
resolver
uniprot_sec
O00680
resolver
uniprot_sec
Q8TBH7
resolver
uniprot_sec
Q92875
resolver
amino_acid_sequence
MGPPHSGPGGVRVGALLLLGVLGLVSGLSLEPVYWNSANKRFQAEGGYVLYPQIGDRLDLLCPRARPPGPHSSPNYEFYKLYLVGGAQGRRCEAPPAPNLLLTCDRPDLDLRFTIKFQEYSPNLWGHEFRSHHDYYIIATSDGTREGLESLQGGVCLTRGMKVLLRVGQSPRGGAVPRKPVSEMPMERDRGAAHSLEPGKENLPGDPTSNATSRGAEGPLPPPSMPAVAGAAGGLALLLLGVAGAGGAMCWRRRRAKPSESRHPGPGSFGRGGSLGLGGGGGMGPREAEPGELGIALRGGGAADPPFCPHYEKVSGDYGHPVYIVQDGPPQSPPNIYYKV
uniprot
proteins
function
FUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250}.; FUNCTION: (Microbial infection) Acts as a receptor for nipah virus and hendra virus. {ECO:0000269|PubMed:16477309, ECO:0000269|PubMed:17376907}.
uniprot
proteins
mass_dalton
35835
uniprot
proteins
mutagenesis
MUTAGEN 124..125; /note="LW->YM: Complete loss of Nipah protein G binding."; /evidence="ECO:0000269|PubMed:16477309
uniprot
proteins
protein_family
Ephrin family
uniprot
proteins
pubmed
10197531
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16477309
uniprot
proteins
pubmed
17376907
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8808709
uniprot
proteins
pubmed
9126477
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 227..247; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins