TRIM55
entrez
84675
canonical
uniprot
Q9BYV6
canonical
ensembl
ENSG00000147573
resolver
ensp
ENSP00000276573
resolver
ensp
ENSP00000297348
resolver
ensp
ENSP00000323913
resolver
ensp
ENSP00000332302
resolver
ensp
ENSP00000527384
resolver
ensp
ENSP00000527386
resolver
genesymbol
TRIM55
resolver
genesymbol_syn
MURF2
resolver
genesymbol_syn
RNF29
resolver
hgnc
HGNC:14215
resolver
uniprot
B3KRC0
resolver
uniprot
B3KRJ3
resolver
uniprot
Q53XX3
resolver
uniprot
Q8IUD9
resolver
uniprot
Q8IUE4
resolver
uniprot
Q96DV2
resolver
uniprot
Q96DV3
resolver
uniprot
Q9BYV5
resolver
uniprot_entry
TRI55_HUMAN
resolver
uniprot_sec
B3KRC0
resolver
uniprot_sec
B3KRJ3
resolver
uniprot_sec
Q53XX3
resolver
uniprot_sec
Q8IUD9
resolver
uniprot_sec
Q8IUE4
resolver
uniprot_sec
Q96DV2
resolver
uniprot_sec
Q96DV3
resolver
uniprot_sec
Q9BYV5
resolver
amino_acid_sequence
MSASLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNPYLPTRGGTTMASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKSDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAILVGSNDRVQGVISQLEDTCKTIEECCRKQKQELCEKFDYLYGILEERKNEMTQVITRTQEEKLEHVRALIKKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLKKISEASKAFQMEKIEHGYENMNHFTVNLNREEKIIREIDFYREDEDEEEEEGGEGEKEGEGEVGGEAVEVEEVENVQTEFPGEDENPEKASELSQVELQAAPGALPVSSPEPPPALPPAADAPVTQGEVVPTGSEQTTESETPVPAAAETADPLFYPSWYKGQTRKATTNPPCTPGSEGLGQIGPPGSEDSNVRKAEVAAAAASERAAVSGKETSAPAATSQIGFEAPPLQGQAAAPASGSGADSEPARHIFSFSWLNSLNE
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays an important role in regulating cardiac development and contractility, muscle growth, metabolism, and fiber-type differentiation. Acts as a critical factor that regulates cardiomyocyte size during development in concert with TRIM63 by regulating E2F1-mediated gene expression (By similarity). Plays a role in apoptosis induction in cardiomyocytes by promoting ubiquitination of the DUSP1 phosphatase. Promotes non-canonical NF-kappa-B signaling and B-cell-mediated immune responses by mediating NFKB2 'Lys-48'-linked ubiquitination and processing. In turn, NFKB2 is further processed by valosin-containing protein/VCP, an ATPase that mediates ubiquitin-dependent protein degradation by the proteasome. May play a role in preventing macrophages from producing inflammatory factors and migrating by down-regulating the level of nuclear NF-kappa-B subunit RELA. Also modifies PPARG via polyubiquitination and accelerates PPARG proteasomal degradation to inhibit its activity (PubMed:36737649). {ECO:0000250|UniProtKB:G3X8Y1, ECO:0000269|PubMed:36737649, ECO:0000269|PubMed:37816088}.
uniprot
proteins
mass_dalton
60466
uniprot
proteins
post_translational_modification
PTM: Targeted for degradation through the proteasomal and lysosomal pathways in the presence of SUMO3. {ECO:0000269|PubMed:37703582}.
uniprot
proteins
pubmed
11243782
uniprot
proteins
pubmed
12414993
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15802564
uniprot
proteins
pubmed
24865491
uniprot
proteins
pubmed
36737649
uniprot
proteins
pubmed
37703582
uniprot
proteins
pubmed
37816088
uniprot
proteins
sequence_length
548
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:G3X8Y1}. Cytoplasm {ECO:0000250|UniProtKB:G3X8Y1}. Note=TLR4 signaling pathway promotes nuclear translocation. {ECO:0000250|UniProtKB:G3X8Y1}.
uniprot
proteins