Scn4b
entrez
399548
canonical
uniprot
Q7M729
canonical
ensembl
ENSMUSG00000046480
resolver
ensp
ENSMUSP00000062507
resolver
enst
ENSMUST00000060125
resolver
genesymbol
Scn4b
resolver
genesymbol_syn
Gm1471
resolver
genesymbol_syn
SCN4B
resolver
uniprot
Q1MXF9
resolver
uniprot_entry
Q1MXF9_MOUSE
resolver
uniprot_entry
SCN4B_MOUSE
resolver
amino_acid_sequence
MSRAGNRGNTQARWLGTGLLGLFLLPMYLSLEVSVGKATTIYAINGSSILLPCTFSSCYGFENLYFKWSYNNSETSRILIDGIVKNDKSDPKVRVKDDDRITLEGSTKEKTNNISILLSDLEFSDTGRYTCFVRNPKEKDLNNSATIFLQVVDKLEKVDNTVTLIILAVVGGVIGLLVCILLLKKLITFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPTKV
uniprot
proteins
function
FUNCTION: Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1. Modulates the activity of SCN2A/Nav1.2. {ECO:0000250|UniProtKB:Q8IWT1}.
uniprot
proteins
mass_dalton
25192
uniprot
proteins
post_translational_modification
PTM: Contains an interchain disulfide bond with SCN2A. {ECO:0000250|UniProtKB:Q8IWT1}.
uniprot
proteins
protein_family
Sodium channel auxiliary subunit SCN4B (TC 8.A.17) family
uniprot
proteins
pubmed
12930796
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IWT1}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8IWT1}.
uniprot
proteins
transmembrane_region
TRANSMEM 162..182; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins