Tmem201
entrez
230917
canonical
uniprot
A2A8U2
canonical
ensembl
ENSMUSG00000044700
resolver
ensp
ENSMUSP00000099497
resolver
ensp
ENSMUSP00000101312
resolver
ensp
ENSMUSP00000270798
resolver
genesymbol
Tmem201
resolver
genesymbol_syn
AV028368
resolver
genesymbol_syn
D4Ertd429e
resolver
genesymbol_syn
Net5
resolver
genesymbol_syn
Samp1
resolver
uniprot
Q3TXY3
resolver
uniprot
Q3U5F3
resolver
uniprot
Q6GQS9
resolver
uniprot
Q8BNY3
resolver
uniprot
Q8C397
resolver
uniprot
Q8C9U2
resolver
uniprot_entry
Q3TXY3_MOUSE
resolver
uniprot_entry
Q8C397_MOUSE
resolver
uniprot_entry
Q8C9U2_MOUSE
resolver
uniprot_entry
TM201_MOUSE
resolver
uniprot_sec
Q3U5F3
resolver
uniprot_sec
Q6GQS9
resolver
uniprot_sec
Q8BNY3
resolver
amino_acid_sequence
MEGVSALLASCPTAGLAGGLGVTACAAAGVVLYRIARRVKPTHTMVNCWFCNHDTLVPYGNRNCWDCPHCEQYNGFQENGDYNKPIPAQYMEHLNHVVSSVPSPRDPAQPQQWVSSQVLLCRRCSHHQTTKIKQLAAFTPREEGRYDEEIEVYRHHLEQMYKLCRPCQAAVEYYIKHQNRQLRALLLSHQFRRREADQAHGQSFSSSAVKAPFQVILLRALAFLACAFLLFTTLYGPSEPFTPGAALPPALPPGGNSSAASDNTTSQAEGWQQLLGLLPEHATEKLHEAWAFGQSHQTSIVAVGLLTCLLAMLLAGRIRLRRIDAFSTCLWALLLGLHLAEHYLQAASPGWLDTLKFSTTSLCCLVGFTAAVATRKSTGPRRFRPRRYFSGDSASLFPSSPSLAVPYPSVTSSPASLFIPTPPGFLPLTKQQLFRSPRRVSPSSLPGRLSRALSLGTIPPLTRTDSGYLFSGSRPPSRVSPAGEVSLSDYFSLLSSSFPASPLPSPAPSVASSVASSSGSLRHRRPLISPARLNLKGQKLLLFSSPGEAPNTPSSSEEFSPPNGSLFIESPQLPQRNHTRDTKHTMEMRSMLARDSARSSHSIKKEDESSQSSTCVVDTTTKGCSEETTPWKARVSPSLVRGLLAVSLAVNALFTSAYLYQSLR
uniprot
proteins
function
FUNCTION: Critical regulator of angiogenesis and endothelial cell (EC) migration. Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope. This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (By similarity). Involved in nuclear movement during fibroblast polarization and migration (PubMed:22349700). May recruit Ran GTPase to the nuclear periphery (By similarity). {ECO:0000250|UniProtKB:Q5SNT2, ECO:0000269|PubMed:22349700, ECO:0000269|PubMed:35311970}.; FUNCTION: [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle. Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina. {ECO:0000250|UniProtKB:Q5SNT2}.; FUNCTION: [Isoform 3]: Proposed to be involved in actin-dependent nuclear movement; via SUN2 associates with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow. {ECO:0000305|PubMed:22349700}.
uniprot
proteins
mass_dalton
72500
uniprot
proteins
protein_family
TMEM201 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22349700
uniprot
proteins
pubmed
35311970
uniprot
proteins
sequence_length
664
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Nucleus inner membrane {ECO:0000250|UniProtKB:Q5SNT2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5SNT2}. Note=The C-terminal of isoform 2 is located on the nucleoplasmic side. During interphase, isoform 2 is distributed in the inner nuclear membrane and during mitosis, it is found in the ER but it also localizes to the polar regions of the mitotic spindle (By similarity). {ECO:0000250|UniProtKB:Q5SNT2}.
uniprot
proteins
transmembrane_region
TRANSMEM 215..235; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 298..318; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 323..343; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 357..374; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 643..663; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins