Atp6v1b2
entrez
117596
canonical
uniprot
P62815
canonical
ensembl
ENSRNOG00000011891
resolver
ensembl
ENSRNOG00055003831
resolver
ensembl
ENSRNOG00060016868
resolver
ensembl
ENSRNOG00065005051
resolver
ensp
ENSRNOP00000015931
resolver
ensp
ENSRNOP00055004576
resolver
ensp
ENSRNOP00060023266
resolver
ensp
ENSRNOP00065005163
resolver
enst
ENSRNOT00055006054
resolver
enst
ENSRNOT00060028899
resolver
enst
ENSRNOT00065007416
resolver
genesymbol
Atp6v1b2
resolver
genesymbol_syn
Atp6b2
resolver
genesymbol_syn
Vat2
resolver
uniprot
O09045
resolver
uniprot
P50517
resolver
uniprot_entry
VATB2_RAT
resolver
uniprot_sec
O09045
resolver
uniprot_sec
P50517
resolver
amino_acid_sequence
MALRAMRGIVNGAAPELPVPTGGPMAGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFEKNFITQGPYENRTVYETLDIGWQLLRIFPKEMLKRIPQSTLSEFYPRDSAKH
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32165585). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32165585). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (By similarity). {ECO:0000250|UniProtKB:P21281, ECO:0000250|UniProtKB:P62814, ECO:0000269|PubMed:32165585}.
uniprot
proteins
mass_dalton
56551
uniprot
proteins
protein_family
ATPase alpha/beta chains family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
32165585
uniprot
proteins
sequence_length
511
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P21281}. Melanosome {ECO:0000250|UniProtKB:P21281}. Cytoplasm {ECO:0000250|UniProtKB:P62814}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:32165585}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:32165585}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins