HNRNPC
entrez
3183
canonical
uniprot
P07910
canonical
ensembl
ENSG00000092199
resolver
ensp
ENSP00000442816
resolver
ensp
ENSP00000450544
resolver
ensp
ENSP00000451291
resolver
ensp
ENSP00000452276
resolver
ensp
ENSP00000531437
resolver
ensp
ENSP00000531441
resolver
ensp
ENSP00000531444
resolver
ensp
ENSP00000531448
resolver
ensp
ENSP00000531456
resolver
ensp
ENSP00000531463
resolver
ensp
ENSP00000531464
resolver
ensp
ENSP00000531468
resolver
ensp
ENSP00000583967
resolver
ensp
ENSP00000618394
resolver
genesymbol
HNRNPC
resolver
genesymbol_syn
HNRPC
resolver
hgnc
HGNC:5035
resolver
uniprot
D3DS19
resolver
uniprot
D3DS22
resolver
uniprot
P22628
resolver
uniprot
Q53EX2
resolver
uniprot
Q59FD3
resolver
uniprot
Q5FWE8
resolver
uniprot
Q86SF8
resolver
uniprot
Q86U45
resolver
uniprot
Q96HK7
resolver
uniprot
Q96HM4
resolver
uniprot
Q96IY5
resolver
uniprot
Q9BTS3
resolver
uniprot_entry
HNRPC_HUMAN
resolver
uniprot_sec
D3DS19
resolver
uniprot_sec
D3DS22
resolver
uniprot_sec
P22628
resolver
uniprot_sec
Q53EX2
resolver
uniprot_sec
Q59FD3
resolver
uniprot_sec
Q5FWE8
resolver
uniprot_sec
Q86SF8
resolver
uniprot_sec
Q86U45
resolver
uniprot_sec
Q96HK7
resolver
uniprot_sec
Q96HM4
resolver
uniprot_sec
Q96IY5
resolver
uniprot_sec
Q9BTS3
resolver
amino_acid_sequence
MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAAEPKVNRGKAGVKRSAAEMYGSVTEHPSPSPLLSSSFDLDYDFQRDYYDRMYSYPARVPPPPPIARAVVPSKRQRVSGNTSRRGKSGFNSKSGQRGSSKSGKLKGDDLQAIKKELTQIKQKVDSLLENLEKIEKEQSKQAVEMKNDKSEEEQSSSSVKKDETNVKMESEGGADDSAEEGDLLDDDDNEDRGDDQLELIKDDEKEAEEGEDDRDSANGEDDS
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, autosomal dominant 74 (MRD74) [MIM:620688]: An autosomal dominant disorder characterized by global developmental delay, including delay of motor skills and speech delay, intellectual disability, behavioral abnormalities, and subtle facial dysmorphology. {ECO:0000269|PubMed:37541189}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}.
uniprot
proteins
mass_dalton
33670
uniprot
proteins
mutagenesis
MUTAGEN 197; /note="K->R: No effect on sumoylation."; /evidence="ECO:0000269|PubMed:15082759"; MUTAGEN 250; /note="K->R: Loss of sumoylation."; /evidence="ECO:0000269|PubMed:15082759
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide. {ECO:0000269|PubMed:12564933}.; PTM: Sumoylated. Sumoylation reduces affinity for mRNA. {ECO:0000269|PubMed:15082759}.; PTM: Ubiquitinated and degraded after nucleo-cytoplasmic transport by YWHAE. {ECO:0000269|PubMed:37599448}.
uniprot
proteins
protein_family
RALY subfamily
uniprot
proteins
protein_family
RRM HNRPC family
uniprot
proteins
pubmed
11162094
uniprot
proteins
pubmed
11687588
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
12509468
uniprot
proteins
pubmed
12564933
uniprot
proteins
pubmed
1380452
uniprot
proteins
pubmed
1385725
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
15082759
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15936032
uniprot
proteins
pubmed
16010978
uniprot
proteins
pubmed
16807684
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17289661
uniprot
proteins
pubmed
17693683
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
2557628
uniprot
proteins
pubmed
25678563
uniprot
proteins
pubmed
25719671
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
2587210
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
3110598
uniprot
proteins
pubmed
37541189
uniprot
proteins
pubmed
37599448
uniprot
proteins
pubmed
7567451
uniprot
proteins
pubmed
8264621
uniprot
proteins
sequence_length
306
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:37599448}. Note=Component of ribonucleosomes.
uniprot
proteins