SENP3
entrez
26168
canonical
uniprot
Q9H4L4
canonical
ensembl
ENSG00000161956
resolver
ensp
ENSP00000314029
resolver
ensp
ENSP00000607930
resolver
enst
ENST00000321337
resolver
enst
ENST00000937871
resolver
genesymbol
SENP3
resolver
genesymbol_syn
SSP3
resolver
genesymbol_syn
SUSP3
resolver
hgnc
HGNC:17862
resolver
uniprot
Q66K15
resolver
uniprot
Q86VS7
resolver
uniprot
Q96PS4
resolver
uniprot
Q9Y3W9
resolver
uniprot_entry
SENP3_HUMAN
resolver
uniprot_sec
Q66K15
resolver
uniprot_sec
Q86VS7
resolver
uniprot_sec
Q96PS4
resolver
uniprot_sec
Q9Y3W9
resolver
activity_regulation
ACTIVITY REGULATION: On oxidative stress, SENP3 degradation is blocked by inhibition of its ubiquitination, which stabilizes it as it accumulates in the nucleoplasm. {ECO:0000269|PubMed:19680224}.
uniprot
proteins
amino_acid_sequence
MKETIQGTGSWGPEPPGPGIPPAYSSPRRERLRWPPPPKPRLKSGGGFGPDPGSGTTVPARRLPVPRPSFDASASEEEEEEEEEEDEDEEEEVAAWRLPPRWSQLGTSQRPRPSRPTHRKTCSQRRRRAMRAFRMLLYSKSTSLTFHWKLWGRHRGRRRGLAHPKNHLSPQQGGATPQVPSPCCRFDSPRGPPPPRLGLLGALMAEDGVRGSPPVPSGPPMEEDGLRWTPKSPLDPDSGLLSCTLPNGFGGQSGPEGERSLAPPDASILISNVCSIGDHVAQELFQGSDLGMAEEAERPGEKAGQHSPLREEHVTCVQSILDEFLQTYGSLIPLSTDEVVEKLEDIFQQEFSTPSRKGLVLQLIQSYQRMPGNAMVRGFRVAYKRHVLTMDDLGTLYGQNWLNDQVMNMYGDLVMDTVPEKVHFFNSFFYDKLRTKGYDGVKRWTKNVDIFNKELLLIPIHLEVHWSLISVDVRRRTITYFDSQRTLNRRCPKHIAKYLQAEAVKKDRLDFHQGWKGYFKMNVARQNNDSDCGAFVLQYCKHLALSQPFSFTQQDMPKLRRQIYKELCHCKLTV
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
function
FUNCTION: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}.
uniprot
proteins
mass_dalton
65010
uniprot
proteins
mutagenesis
MUTAGEN 532; /note="C->S: Loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:36050397
uniprot
proteins
protein_family
Peptidase C48 family
uniprot
proteins
pubmed
10806345
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15743823
uniprot
proteins
pubmed
15960975
uniprot
proteins
pubmed
16608850
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18259216
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18946085
uniprot
proteins
pubmed
19015314
uniprot
proteins
pubmed
19680224
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
22872859
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25406032
uniprot
proteins
pubmed
32832608
uniprot
proteins
pubmed
36050397
uniprot
proteins
sequence_length
574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:19680224}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224}. Cytoplasm {ECO:0000250|UniProtKB:Q9EP97}. Note=Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress (PubMed:19680224). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). {ECO:0000250|UniProtKB:Q9EP97, ECO:0000269|PubMed:19680224}.
uniprot
proteins