INTS3
entrez
65123
canonical
uniprot
Q68E01
canonical
ensembl
ENSG00000143624
resolver
ensembl
ENSG00000262826
resolver
ensp
ENSP00000318641
resolver
ensp
ENSP00000404290
resolver
genesymbol
INTS3
resolver
genesymbol_syn
C1orf193
resolver
genesymbol_syn
C1orf60
resolver
hgnc
HGNC:26153
resolver
uniprot
A8K1W0
resolver
uniprot
B4DQC8
resolver
uniprot
B4E3U9
resolver
uniprot
D3DV57
resolver
uniprot
Q4G0E5
resolver
uniprot
Q5VUQ5
resolver
uniprot
Q5VUQ6
resolver
uniprot
Q5VUR0
resolver
uniprot
Q5VUR1
resolver
uniprot
Q68DJ1
resolver
uniprot
Q69YR5
resolver
uniprot
Q6AI57
resolver
uniprot
Q6DKG7
resolver
uniprot
Q6MZQ4
resolver
uniprot
Q6MZZ9
resolver
uniprot
Q8NC46
resolver
uniprot
Q8TB23
resolver
uniprot
Q9H6S9
resolver
uniprot_entry
INT3_HUMAN
resolver
uniprot_sec
A8K1W0
resolver
uniprot_sec
B4DQC8
resolver
uniprot_sec
B4E3U9
resolver
uniprot_sec
D3DV57
resolver
uniprot_sec
Q4G0E5
resolver
uniprot_sec
Q5VUQ5
resolver
uniprot_sec
Q5VUQ6
resolver
uniprot_sec
Q5VUR0
resolver
uniprot_sec
Q5VUR1
resolver
uniprot_sec
Q68DJ1
resolver
uniprot_sec
Q69YR5
resolver
uniprot_sec
Q6AI57
resolver
uniprot_sec
Q6DKG7
resolver
uniprot_sec
Q6MZQ4
resolver
uniprot_sec
Q6MZZ9
resolver
uniprot_sec
Q8NC46
resolver
uniprot_sec
Q8TB23
resolver
uniprot_sec
Q9H6S9
resolver
amino_acid_sequence
MELQKGKGAAAAAAASGAAGGGGGGAGAGAPGGGRLLLSTSLDAKDELEERLERCMSIVTSMTAGVSEREANDALNAYVCKGLPQHEEICLGLFTLILTEPAQAQKCYRDLALVSRDGMNIVLNKINQILMEKYLKLQDTCRTQLVWLVRELVKSGVLGADGVCMTFMKQIAGGGDVTAKNIWLAESVLDILTEQREWVLKSSILIAMAVYTYLRLIVDHHGTAQLQALRQKEVDFCISLLRERFMECLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQSRTSRKFLACRLTPDMETKLLFMTSRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRAMLREKFPEFCSSPSPPVEVKIEEPVSMEMDNHMSDKDESCYDNAEAAFSDDEEDLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDESLRDKVLQLQKGSDTEAQCEVMQEIVDQVLEEDFDSEQLSVLASCLQELFKAHFRGEVLPEEITEESLEESVGKPLYLIFRNLCQMQEDNSSFSLLLDLLSELYQKQPKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDLHTCLMMDMKACQEDDVRLLCHLTPSIYTEFPDETLRSGELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEALSCLLLQLRREKPSEEMVKMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKSLLIKNNSLPRKRQSLRSSSSKLAQLTLEQILEHLDNLRLNLTNTKQNFFSQTPILQALQHVQASCDEAHKMKFSDLFSLAEEYEDSSTKPPKSRRKAALSSPRSRKNATQPPNAEEESGSSSASEEEDTKPKPTKRKRKGSSAVGSDSD
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS3 is involved in the post-termination step: INTS3 binds INTS7 in the open conformation of integrator complex and prevents the rebinding of Pol II to the integrator after termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:38570683}.; FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}.
uniprot
proteins
mass_dalton
118070
uniprot
proteins
protein_family
Integrator subunit 3 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16239144
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19605351
uniprot
proteins
pubmed
19683501
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23904267
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29471365
uniprot
proteins
pubmed
38570683
uniprot
proteins
pubmed
39032490
uniprot
proteins
sequence_length
1043
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:29471365, ECO:0000269|PubMed:39032490}. Cytoplasm {ECO:0000269|PubMed:23904267}. Note=Localizes to nuclear foci following DNA damage. {ECO:0000269|PubMed:19683501}.
uniprot
proteins