Acsl5
entrez
94340
canonical
uniprot
O88813
canonical
ensembl
ENSRNOG00000016265
resolver
ensp
ENSRNOP00000022126
resolver
ensp
ENSRNOP00000078386
resolver
ensp
ENSRNOP00000080415
resolver
enst
ENSRNOT00000022126
resolver
enst
ENSRNOT00000110033
resolver
genesymbol
Acsl5
resolver
genesymbol_syn
Acs5
resolver
genesymbol_syn
Facl5
resolver
uniprot
A0ABZ3NN85
resolver
uniprot
A0ACM8Q4A5
resolver
uniprot
A6JHY8
resolver
uniprot
F1LPB3
resolver
uniprot
Q6IN15
resolver
uniprot_entry
A0ABZ3NN85_RAT
resolver
uniprot_entry
A0ACM8Q4A5_RAT
resolver
uniprot_entry
A6JHY8_RAT
resolver
uniprot_entry
ACSL5_RAT
resolver
uniprot_sec
F1LPB3
resolver
uniprot_sec
Q6IN15
resolver
amino_acid_sequence
MLFIFNFLFSPLPTPALICLLTFGTAIFLWLINRPQPVLPLIDLDNQSVGIEGGARRGAFQKNNDLILYYFSDAKTLYEVFQRGLAVSDNGPCLGYRKPNQPYKWISYKQVSDRAEYLGSCLLHKGYKPSQDQFIGIFAQNRPEWVISELACYTYSMVAVPLYDTLGAEAIIYVINRADISVVICDTPQKATMLIENVEKDLTPGLKTVILMDPFDDDLMKRGEKCGIEMLSLHDAENLGKENFKKPMPPNPEDLSVICFTSGTTGDPKGAMLTHQNIVSNMAAFLKFLEPIFQPTPEDVTISYLPLAHMFERLVQGVIFSCGGKIGFFQGDIRLLPDDMKALKPTVFPTVPRLLNRVYDKVQNEAKTPLKKFLLNLAIISKFNEVRNGIIRRNSLWDKLVFSKIQSSLGGKVRLMITGAAPISTPVLTFFRAAMGCWVFEAYGQTECTAGCSITSPGDWTAGHVGTPVSCNFVKLEDVADMNYFSVNNEGEICIKGNNVFKGYLKDPEKTQEVLDKDGWLHTGDIGRWLPNGTLKIIDRKKNIFKLAQGEYIAPEKIENVYSRSRPILQVFVHGESLRSFLIGVVVPDPESLPSFAAKIGVKGSFEELCQNQCVKKAILEDLQKVGKEGGLKSFEQVKSIFVHPEPFSIENGLLTPTLKAKRVELAKFFQTQIKSLYESIEE
uniprot
proteins
ec_number
6.2.1.15
uniprot
proteins
ec_number
6.2.1.3
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:28209804). ACSL5 may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL at the villus tip of the crypt-villus axis of the small intestine (By similarity). May have a role in the survival of glioma cells (By similarity). May activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. It was suggested that it may also stimulate fatty acid oxidation. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids. {ECO:0000250, ECO:0000269|PubMed:16263710, ECO:0000269|PubMed:17761945, ECO:0000269|PubMed:28209804, ECO:0000269|PubMed:9722683}.
uniprot
proteins
mass_dalton
76405
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
15683247
uniprot
proteins
pubmed
16263710
uniprot
proteins
pubmed
17761945
uniprot
proteins
pubmed
28209804
uniprot
proteins
pubmed
29196521
uniprot
proteins
pubmed
9722683
uniprot
proteins
sequence_length
683
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16263710}. Endoplasmic reticulum {ECO:0000269|PubMed:16263710}. Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:Q9ULC5}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins