Pacsin1
entrez
29704
canonical
uniprot
Q9Z0W5
canonical
ensembl
ENSRNOG00000054603
resolver
ensembl
ENSRNOG00065024677
resolver
ensp
ENSRNOP00000089554
resolver
ensp
ENSRNOP00065034675
resolver
enst
ENSRNOT00000094726
resolver
enst
ENSRNOT00065042381
resolver
genesymbol
Pacsin1
resolver
uniprot
A0A8I6A7J3
resolver
uniprot_entry
A0A8I6A7J3_RAT
resolver
uniprot_entry
PACN1_RAT
resolver
amino_acid_sequence
MSGPYDEASEEITDSFWEVGNYKRTVKRIDDGHRLCNDLMSCVQERAKIEKAYAQQLTDWAKRWRQLIEKGPQYGSLERAWGAMMTEADKVSELHQEVKNSLLNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSVTPEQQKKLVDKVDKCRQDVQKTQEKYEKVLEDVGKTTPQYMEGMEQVFEQCQQFEEKRLVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTAAKKEKQPKKAEGAALSNATGAVESTSQAGDRGSVSSYDRGQAYATEWSDDESGNPFGGNEANGGANPFEDDAKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI
uniprot
proteins
function
FUNCTION: Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission. {ECO:0000269|PubMed:16648848, ECO:0000269|PubMed:17437541, ECO:0000269|PubMed:19846719, ECO:0000269|PubMed:21725280, ECO:0000269|PubMed:22355135}.
uniprot
proteins
mass_dalton
50449
uniprot
proteins
mutagenesis
MUTAGEN 62..63; /note="KR->QQ: Reduces membrane-binding. Abolishes membrane tubulation."; /evidence="ECO:0000269|PubMed:22355135"; MUTAGEN 76; /note="S->A: No effect on membrane-binding. Reduces membrane tubulation."; /evidence="ECO:0000269|PubMed:22355135"; MUTAGEN 127; /note="K->Q: Reduces membrane-binding; when associated with Q-130. Abolishes membrane tubulation."; /evidence="ECO:0000269|PubMed:22355135"; MUTAGEN 130; /note="K->Q: Reduces membrane-binding. Abolishes membrane tubulation; when associated with Q-127."; /evidence="ECO:0000269|PubMed:22355135"; MUTAGEN 154..155; /note="KK->QQ: Reduces membrane-binding. Abolishes membrane tubulation."; /evidence="ECO:0000269|PubMed:22355135"; MUTAGEN 181; /note="T->A: No effect on membrane-binding."; /evidence="ECO:0000269|PubMed:22355135"; MUTAGEN 181; /note="T->E: Reduces membrane-binding. Abolishes membrane tubulation."; /evidence="ECO:0000269|PubMed:22355135"; MUTAGEN 276; /note="D->A: Reduces membrane tubulation; when associated with A-280."; /evidence="ECO:0000269|PubMed:22355135"; MUTAGEN 280; /note="D->A: Reduces membrane tubulation; when associated with A-276."; /evidence="ECO:0000269|PubMed:22355135"; MUTAGEN 434; /note="P->L: Abolishes interaction with DNM1, SYNJ1 and WASL."; /evidence="ECO:0000269|PubMed:9950691
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). {ECO:0000305|PubMed:22355135}.
uniprot
proteins
protein_family
PACSIN family
uniprot
proteins
pubmed
11082044
uniprot
proteins
pubmed
15930129
uniprot
proteins
pubmed
16648848
uniprot
proteins
pubmed
17437541
uniprot
proteins
pubmed
17956734
uniprot
proteins
pubmed
19846719
uniprot
proteins
pubmed
21725280
uniprot
proteins
pubmed
22355135
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9950691
uniprot
proteins
sequence_length
441
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell projection. Synapse, synaptosome. Cell projection, ruffle membrane {ECO:0000250}. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with MAPT in axons (By similarity). In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites. {ECO:0000250}.
uniprot
proteins