HDGFL2
entrez
84717
canonical
uniprot
Q7Z4V5
canonical
ensembl
ENSG00000167674
resolver
ensp
ENSP00000483345
resolver
ensp
ENSP00000483702
resolver
ensp
ENSP00000571420
resolver
ensp
ENSP00000571421
resolver
genesymbol
HDGFL2
resolver
genesymbol_syn
HDGF2
resolver
genesymbol_syn
HDGFRP2
resolver
genesymbol_syn
HRP2
resolver
hgnc
HGNC:14680
resolver
uniprot
I3L080
resolver
uniprot
K7EQZ6
resolver
uniprot
Q96GI5
resolver
uniprot
Q9BW08
resolver
uniprot_entry
HDGR2_HUMAN
resolver
uniprot_sec
I3L080
resolver
uniprot_sec
K7EQZ6
resolver
uniprot_sec
Q96GI5
resolver
uniprot_sec
Q9BW08
resolver
amino_acid_sequence
MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERARGDSEALDEES
uniprot
proteins
function
FUNCTION: Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}.
uniprot
proteins
mass_dalton
74317
uniprot
proteins
mutagenesis
MUTAGEN 21; /note="W->A: Loss of interaction with histone H3K36me2."; /evidence="ECO:0000269|PubMed:32459350"; MUTAGEN 527..528; /note="RR->AA,DD: Loss of interaction with SMARCA4, SMARCC1, SMARCD1 and DPF3/BAF45C isoform 2."; /evidence="ECO:0000269|PubMed:32459350
uniprot
proteins
protein_family
HDGF family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21720545
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25689719
uniprot
proteins
pubmed
26721387
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
32459350
uniprot
proteins
pubmed
34415726
uniprot
proteins
sequence_length
671
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26721387}. Cytoplasm {ECO:0000250|UniProtKB:Q925G1}.
uniprot
proteins