Clcc1
entrez
170927
canonical
uniprot
Q9WU61
canonical
ensembl
ENSRNOG00000020360
resolver
ensembl
ENSRNOG00060028126
resolver
ensp
ENSRNOP00000042185
resolver
enst
ENSRNOT00000051701
resolver
genesymbol
Clcc1
resolver
genesymbol_syn
Mclc
resolver
uniprot
A0A140TAF5
resolver
uniprot
Q66HQ5
resolver
uniprot
Q8VIE8
resolver
uniprot
Q8VIE9
resolver
uniprot
Q8VIF0
resolver
uniprot
Q8VIF1
resolver
uniprot_entry
A0A140TAF5_RAT
resolver
uniprot_entry
CLCC1_RAT
resolver
uniprot_sec
Q66HQ5
resolver
uniprot_sec
Q8VIE8
resolver
uniprot_sec
Q8VIE9
resolver
uniprot_sec
Q8VIF0
resolver
uniprot_sec
Q8VIF1
resolver
amino_acid_sequence
MLCSLLLCGCLLLITGYAHDDDWIDPTDMLNYDAASGTMRKSQAKYGTSEKKEVNPGLSDAQELSDCLQRLDSLTHKVDDCEKKKMKDYESQSNPVFRRYLNKILIEAGKLGLPDEDRVDVRYDAEILLTRQTLLEIQKFLSGEEWKPGALDDALSDILTNFKSHDAEAWKWQFEDYFGVDPYNVFMVLLCLLCIVALVATELWTYVRWHTQLKRVCIISFLVSLGWNWIYLYKVAFAQHQANVAKMAPLNDVCAKKMDWTENLWEWFRISWTYKDDPCQKYYELLIVNPIWLVPPTKALAVTFTNFVTEPLKYIGKGTGEFIKALMKEIPVLLQIPVLVILALAVLGFCYGAGQSVPMLRHFRGPEREPPRALEPDDRRRQKELDYRFHGGAGDADFSYRGPAGSIEQGPYDKMHVCERDVLRQRQVNMRFPSGNKSPEVLRAFDLPDTEAQEHPEVVPSHKPSIVNTSLKETSELPRESTLAECSQCAKDGSGQVPSTAESSPIVEKAQLKTDSECRPHSTEAAAAAARGTDPVSSPCG
uniprot
proteins
function
FUNCTION: Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity) (PubMed:11279057). {ECO:0000250|UniProtKB:Q96S66, ECO:0000250|UniProtKB:Q99LI2, ECO:0000269|PubMed:11279057}.
uniprot
proteins
mass_dalton
61174
uniprot
proteins
protein_family
Chloride channel MCLC family
uniprot
proteins
pubmed
11279057
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11279057}; Multi-pass membrane protein {ECO:0000255}. Note=Within the endoplasmic reticulum (ER), localizes to the mitochondria-associated ER membrane, a zone of contact between the ER and mitochondrial membranes. Enriched in the rough ER. {ECO:0000250|UniProtKB:Q96S66, ECO:0000250|UniProtKB:Q99LI2}.
uniprot
proteins
transmembrane_region
TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 218..238; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 330..350; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins