Atp11a
entrez
50770
canonical
uniprot
P98197
canonical
ensembl
ENSMUSG00000031441
resolver
ensp
ENSMUSP00000033818
resolver
ensp
ENSMUSP00000088779
resolver
ensp
ENSMUSP00000303899
resolver
ensp
ENSMUSP00000303900
resolver
ensp
ENSMUSP00000303901
resolver
enst
ENSMUST00000033818
resolver
enst
ENSMUST00000091237
resolver
genesymbol
Atp11a
resolver
uniprot
B2RS49
resolver
uniprot
E9Q3G7
resolver
uniprot_entry
AT11A_MOUSE
resolver
uniprot_entry
E9Q3G7_MOUSE
resolver
uniprot_sec
B2RS49
resolver
amino_acid_sequence
MDCSLLRTLVRRYCAGEENWVDSRTIYVGHKEPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRIANFYFLIIFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSNRADGTCHVTTASLDGESSHKTHYAVQDTKGFHTEADVDSLHATIECEQPQPDLYKFVGRINVYNDLNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNTFLIVYLCILVSKALINTVLKYVWQSEPFRDEPWYNEKTESERQRNLFLRAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEEMGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMAFKECCIEGHVYVPHVICNGQVLPDSSGIDMIDSSPGVCGREREELFFRAICLCHTVQVKDDHCGDDVDGPQKSPDAKSCVYISSSPDEVALVEGVQRLGFTYLRLKDNYMEILNRENDIERFELLEVLTFDSVRRRMSVIVKSTTGEIYLFCKGADSSIFPRVIEGKVDQVRSRVERNAVEGLRTLCVAYKRLEPEQYEDACRLLQSAKVALQDREKKLAEAYEQIEKDLVLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETASATCYACKLFRRSTQLLELTTKKLEEQSLHDVLFDLSKTVLRCSGSMTRDSFSGLSTDMHDYGLIIDGAALSLIMKPREDGSSSGNYRELFLEICRNCSAVLCCRMAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDIAKNALLRWRVFIYWTFLGVFDALVFFFGAYFIFENTTVTINGQMFGNWTFGTLVFTVMVLTVTLKLALDTHYWTWINHFVIWGSLLFYIAFSLLWGGVIWPFLSYQRMYYVFISMLSSGPAWLGIILLVTVGLLPDVLKKVLCRQLWPTATERTQNIQHQDSISEFTPLASLPSWGAQGSRLLAAQCSSPSGRVVCSRWESEECPVLPLHPGLPHKARYGCCRSSLEMPT
uniprot
proteins
ec_number
7.6.2.1
uniprot
proteins
function
FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (By similarity). Does not show flippase activity toward phosphatidylcholine (PC) (By similarity). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). {ECO:0000250|UniProtKB:P98196, ECO:0000269|PubMed:29799007}.
uniprot
proteins
mass_dalton
135502
uniprot
proteins
mutagenesis
MUTAGEN 84; /note="Q->E: Mutant mice surviving beyond the perinatal period show a reduction in brain size, dilated lateral ventricles and neurologic deficits. Increased sphingomyelin levels in various regions of mutant embryos."; /evidence="ECO:0000269|PubMed:34403372
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by CASP3. {ECO:0000250|UniProtKB:P98196}.
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IV subfamily
uniprot
proteins
pubmed
11015572
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29799007
uniprot
proteins
pubmed
30018401
uniprot
proteins
pubmed
34403372
uniprot
proteins
pubmed
36300302
uniprot
proteins
sequence_length
1187
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29799007}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000250|UniProtKB:P98196}. Recycling endosome {ECO:0000250|UniProtKB:P98196}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P98196}; Multi-pass membrane protein {ECO:0000255}. Note=Efficient exit from the endoplasmic reticulum requires the presence of CDC50A. {ECO:0000250|UniProtKB:P98196}.
uniprot
proteins
transmembrane_region
TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 89..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 297..318; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 350..372; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 885..905; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 918..937; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 968..989; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1004..1026; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1033..1053; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1072..1096; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins