ITGB7
entrez
3695
canonical
uniprot
P26010
canonical
ensembl
ENSG00000139626
resolver
ensp
ENSP00000267082
resolver
ensp
ENSP00000408741
resolver
ensp
ENSP00000455374
resolver
ensp
ENSP00000521234
resolver
ensp
ENSP00000521237
resolver
genesymbol
ITGB7
resolver
hgnc
HGNC:6162
resolver
uniprot
Q9UCP7
resolver
uniprot
Q9UCS7
resolver
uniprot_entry
ITB7_HUMAN
resolver
uniprot_sec
Q9UCP7
resolver
uniprot_sec
Q9UCS7
resolver
amino_acid_sequence
MVALPMVLVLLLVLSRGESELDAKIPSTGDATEWRNPHLSMLGSCQPAPSCQKCILSHPSCAWCKQLNFTASGEAEARRCARREELLARGCPLEELEEPRGQQEVLQDQPLSQGARGEGATQLAPQRVRVTLRPGEPQQLQVRFLRAEGYPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRHPCPTRLERCQSPFSFHHVLSLTGDAQAFEREVGRQSVSGNLDSPEGGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGKLGGIFMPSDGHCHLDSNGLYSRSTEFDYPSVGQVAQALSAANIQPIFAVTSAALPVYQELSKLIPKSAVGELSEDSSNVVQLIMDAYNSLSSTVTLEHSSLPPGVHISYESQCEGPEKREGKAEDRGQCNHVRINQTVTFWVSLQATHCLPEPHLLRLRALGFSEELIVELHTLCDCNCSDTQPQAPHCSDGQGHLQCGVCSCAPGRLGRLCECSVAELSSPDLESGCRAPNGTGPLCSGKGHCQCGRCSCSGQSSGHLCECDDASCERHEGILCGGFGRCQCGVCHCHANRTGRACECSGDMDSCISPEGGLCSGHGRCKCNRCQCLDGYYGALCDQCPGCKTPCERHRDCAECGAFRTGPLATNCSTACAHTNVTLALAPILDDGWCKERTLDNQLFFFLVEDDARGTVVLRVRPQEKGADHTQAIVLGCVGGIVAVGLGLVLAYRLSVEIYDRREYSRFEKEQQQLNWKQDSNPLYKSAITTTINPRFQEADSPTL
uniprot
proteins
function
FUNCTION: Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) (Probable). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract (PubMed:10837471, PubMed:14608374). Also interacts with VCAM1 and fibronectin, an extracellular matrix component (Probable). It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin (Probable). Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin (Probable). Integrin ITGAE/ITGB7 (alpha-E/beta-7, HML-1) is a receptor for E-cadherin (PubMed:10837471). {ECO:0000269|PubMed:10837471, ECO:0000269|PubMed:14608374, ECO:0000305|PubMed:12297042}.; FUNCTION: (Microbial infection) Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. {ECO:0000269|PubMed:18264102}.
uniprot
proteins
mass_dalton
86903
uniprot
proteins
mutagenesis
MUTAGEN 159; /note="D->A: Loss of integrin alpha-E/beta-7 binding to E-cadherin and of integrin alpha-4/beta-7 binding to MADCAM1."; /evidence="ECO:0000269|PubMed:10837471
uniprot
proteins
protein_family
Integrin beta chain family
uniprot
proteins
pubmed
10837471
uniprot
proteins
pubmed
12297042
uniprot
proteins
pubmed
1382574
uniprot
proteins
pubmed
14608374
uniprot
proteins
pubmed
1542691
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16455489
uniprot
proteins
pubmed
1750505
uniprot
proteins
pubmed
1777426
uniprot
proteins
pubmed
18264102
uniprot
proteins
pubmed
19828450
uniprot
proteins
pubmed
2040616
uniprot
proteins
pubmed
2083230
uniprot
proteins
pubmed
22232704
uniprot
proteins
pubmed
38781659
uniprot
proteins
sequence_length
798
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 724..746; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins