Sap18
entrez
20220
canonical
uniprot
O55128
canonical
ensembl
ENSMUSG00000021963
resolver
ensp
ENSMUSP00000120071
resolver
genesymbol
Sap18
resolver
uniprot
Q4FZH3
resolver
uniprot
Q545L4
resolver
uniprot_entry
Q4FZH3_MOUSE
resolver
uniprot_entry
SAP18_MOUSE
resolver
uniprot_sec
Q545L4
resolver
amino_acid_sequence
MAVESRVTQEEIKKEPEKPIDREKTCPLLLRVFTTNNGRHHRMDEFSRGNVPSSELQIYTWMDATLKELTSLVKEVYPEARKKGTHFNFAIVFMDLKRPGYRVKEIGSTMSGRKGTDDSMTLQSQKFQIGDYLDIAITPPNRAPPSSGRMRPY
uniprot
proteins
function
FUNCTION: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function (By similarity). {ECO:0000250, ECO:0000269|PubMed:22388736}.
uniprot
proteins
mass_dalton
17595
uniprot
proteins
mutagenesis
MUTAGEN 26; /note="C->R: Impairs interactions with RNPS1, ACIN1 and PNN; reduces ASAP and PSAP complex assemblies."; /evidence="ECO:0000269|PubMed:22388736
uniprot
proteins
protein_family
SAP18 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22388736
uniprot
proteins
pubmed
9511770
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O00422}. Cytoplasm {ECO:0000250|UniProtKB:O00422}. Nucleus speckle {ECO:0000250|UniProtKB:O00422}. Note=Shuttles between the nucleus and the cytoplasm (By similarity). Colocalizes with ACIN1 and SRSF2 in nuclear speckles (By similarity). {ECO:0000250|UniProtKB:O00422}.
uniprot
proteins