NCKAP1
entrez
10787
canonical
uniprot
Q9Y2A7
canonical
ensembl
ENSG00000061676
resolver
ensp
ENSP00000354251
resolver
ensp
ENSP00000355348
resolver
ensp
ENSP00000515489
resolver
ensp
ENSP00000515490
resolver
enst
ENST00000703824
resolver
enst
ENST00000703825
resolver
genesymbol
NCKAP1
resolver
genesymbol_syn
HEM2
resolver
genesymbol_syn
KIAA0587
resolver
genesymbol_syn
NAP1
resolver
hgnc
HGNC:7666
resolver
uniprot
A0A994J4I5
resolver
uniprot
A0A994J6K9
resolver
uniprot
O60329
resolver
uniprot
Q53QN5
resolver
uniprot
Q53S94
resolver
uniprot
Q53Y35
resolver
uniprot_entry
A0A994J4I5_HUMAN
resolver
uniprot_entry
A0A994J6K9_HUMAN
resolver
uniprot_entry
NCKP1_HUMAN
resolver
uniprot_sec
O60329
resolver
uniprot_sec
Q53QN5
resolver
uniprot_sec
Q53S94
resolver
uniprot_sec
Q53Y35
resolver
amino_acid_sequence
MSRSVLQPSQQKLAEKLTILNDRGVGMLTRLYNIKKACGDPKAKPSYLIDKNLESAVKFIVRKFPAVETRNNNQQLAQLQKEKSEILKNLALYYFTFVDVMEFKDHVCELLNTIDVCQVFFDITVNFDLTKNYLDLIITYTTLMILLSRIEERKAIIGLYNYAHEMTHGASDREYPRLGQMIVDYENPLKKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDTMPCEYLSLDAMEKWIIFGFILCHGILNTDATALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNKRINDIRECKEAAVSHAGSMHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIWLLRHADNMPKKSADDFIDKHIAELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLGLADHRELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSIAFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMVVWEHTFTPREYLTSHLEIRFTKSIVGMTMYNQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDISEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQMRTSFDKPDQMAALFKRLSSVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSSAAGLPCEIDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTIHKGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIVQESPFLTMDLLESCFPYVLLRNAYHAVYKQSVTSSA
uniprot
proteins
function
FUNCTION: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. {ECO:0000250|UniProtKB:P28660}.
uniprot
proteins
mass_dalton
128790
uniprot
proteins
protein_family
HEM-1/HEM-2 family
uniprot
proteins
pubmed
10673335
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21107423
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25121749
uniprot
proteins
pubmed
28940097
uniprot
proteins
pubmed
29288388
uniprot
proteins
pubmed
33726789
uniprot
proteins
pubmed
9628581
uniprot
proteins
sequence_length
1128
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P28660}; Single-pass membrane protein {ECO:0000250|UniProtKB:P28660}; Cytoplasmic side {ECO:0000250|UniProtKB:P28660}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:P28660}; Single-pass membrane protein {ECO:0000250|UniProtKB:P28660}; Cytoplasmic side {ECO:0000250|UniProtKB:P28660}. Note=At the interface between the lamellipodial actin meshwork and the membrane. {ECO:0000250|UniProtKB:P28660}.
uniprot
proteins
transmembrane_region
TRANSMEM 995..1015; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins