Ak4
entrez
11639
canonical
uniprot
Q9WUR9
canonical
ensembl
ENSMUSG00000028527
resolver
ensp
ENSMUSP00000099841
resolver
ensp
ENSMUSP00000102558
resolver
ensp
ENSMUSP00000102559
resolver
ensp
ENSMUSP00000121112
resolver
ensp
ENSMUSP00000332127
resolver
enst
ENSMUST00000102780
resolver
enst
ENSMUST00000106945
resolver
enst
ENSMUST00000106946
resolver
genesymbol
Ak4
resolver
genesymbol_syn
AK3L1
resolver
genesymbol_syn
AK4
resolver
genesymbol_syn
Ak-4
resolver
genesymbol_syn
Ak3b
resolver
genesymbol_syn
Ak3l1
resolver
uniprot
Q3U489
resolver
uniprot
Q9R1X7
resolver
uniprot_entry
KAD4_MOUSE
resolver
uniprot_entry
Q3U489_MOUSE
resolver
uniprot_sec
Q9R1X7
resolver
amino_acid_sequence
MASKLLRAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTGTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQHWLLDGFPRTLVQAEALDGICDVDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVQGIDDITGEPLVQQEDDKPEAVAARLRRYKDAAKPVIELYKSRGVLHQFSGTETNRIWPYVYTLFSNKITPIQSKEAY
uniprot
proteins
ec_number
2.7.4.4
uniprot
proteins
ec_number
2.7.4.6
uniprot
proteins
function
FUNCTION: Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions. Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP. Phosphorylates only AMP when using GTP as phosphate donor. In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor. Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors. Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK. Plays a protective role in the cellular response to oxidative stress. {ECO:0000250|UniProtKB:P27144}.
uniprot
proteins
mass_dalton
25062
uniprot
proteins
protein_family
AK3 subfamily
uniprot
proteins
protein_family
Adenylate kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19130895
uniprot
proteins
pubmed
19492028
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
9813319
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P27144, ECO:0000255|HAMAP-Rule:MF_03170}.
uniprot
proteins