Ppara
entrez
25747
canonical
uniprot
P37230
canonical
ensembl
ENSRNOG00000021463
resolver
ensembl
ENSRNOG00055032099
resolver
ensembl
ENSRNOG00060023253
resolver
ensembl
ENSRNOG00065033228
resolver
ensp
ENSRNOP00000112415
resolver
ensp
ENSRNOP00055045786
resolver
ensp
ENSRNOP00060033175
resolver
ensp
ENSRNOP00065047023
resolver
enst
ENSRNOT00000136133
resolver
enst
ENSRNOT00055055491
resolver
enst
ENSRNOT00060040199
resolver
enst
ENSRNOT00065057129
resolver
genesymbol
Ppara
resolver
genesymbol_syn
Nr1c1
resolver
genesymbol_syn
Ppar
resolver
uniprot_entry
PPARA_RAT
resolver
amino_acid_sequence
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSLGEESSGSFSFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPAVPTSTDESPGNALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLAKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVENKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
uniprot
proteins
function
FUNCTION: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
52377
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:8828512}.; PTM: Ubiquitinated by E3 ubiquitin-protein ligase HUWE1; leading to proteasomal degradation. {ECO:0000250|UniProtKB:P23204}.
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
1316614
uniprot
proteins
pubmed
15051727
uniprot
proteins
pubmed
8828512
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins