Q02955
uniprot
Q02955
canonical
amino_acid_sequence
MENMKVLLGFICLIVPLLSLETDKCTEYPNEVISFSSVNEIDIRSCPLTPNEMHGGTIIWYKNDSKTPISADKDSRIHQQNEHLWFVPAKMEDSGYYYCIMRNSTYCLKTKITMSVLENDPGLCYNTQASFIQRLHVAGDGSLVCPYLDFFKDENNELPKVQWYKNCKPLPLDDGNFFGFKNKLMVMNVAEEHRGNYTCRTSYTYQGKQYPVTRVITFITIDDSKRDRPVIMSPRNETMEADPGSTIQLICNVTGQFTDLVYWKWNGSEIEWDDPILAEDYQFLEHPSAKRKYTLITTLNVSEVKSQFYRYPFICFVKNTHILETAHVRLVYPVPDFKNYLIGGFAIFTATAVFCACIYKVFKVDIVLWYRDSCSDFLPRKASDGRTYDAYVLYPKTYGEGSFAYLDTFVFKLLPEVLEGQFGYKLFICGRDDYVGEDTIEVTNENVKRSRRLIIILVRDMGSFSCLGQSSEEQIAIYDALIREGIKIILLELEKIQDYEKMPESIQFIKQKHGAICWSGDFKERPQSAKTRFWKNLRYQMPAQRRSPLSKHHLLTLDPVLDTKEKLQAETHLPLG
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity). {ECO:0000250|UniProtKB:P14778}.
uniprot
proteins
mass_dalton
66759
uniprot
proteins
post_translational_modification
PTM: A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding). {ECO:0000250}.; PTM: Rapidly phosphorylated on Tyr-499 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1. {ECO:0000250}.
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
7684399
uniprot
proteins
sequence_length
576
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000305}. Secreted {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 339..359; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins