Katna1
entrez
292464
canonical
uniprot
Q6E0V2
canonical
ensembl
ENSRNOG00000014996
resolver
ensp
ENSRNOP00000020417
resolver
enst
ENSRNOT00000020417
resolver
genesymbol
Katna1
resolver
genesymbol_syn
KATNA1
resolver
uniprot
Q4V7G3
resolver
uniprot
Z4YNM2
resolver
uniprot_entry
KTNA1_RAT
resolver
uniprot_entry
Z4YNM2_RAT
resolver
uniprot_sec
Q4V7G3
resolver
activity_regulation
ACTIVITY REGULATION: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1. {ECO:0000255|HAMAP-Rule:MF_03023}.
uniprot
proteins
amino_acid_sequence
MSLLMITENVKLAREYALLGNYDSAMVYYQGVLDQINKYLYSVKDTHLHQKWQQVWQEINVEAKHVKEIMKTLESFKLDSTSLKAAQHELPSSEGEVWSLPVPVERRPLPGPRKRQSTQHSDPKPHSNRPGAVVRAHRPSAQSLHSDRGKAVRSREKKEQSKGREEKNKLPAAVTEPEANKFDSTGYDKDLVEALERDIISQNPNVRWYDIADLVEAKKLLQEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVNLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSREEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIVEFGSC
uniprot
proteins
ec_number
5.6.1.1
uniprot
proteins
function
FUNCTION: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10209026, ECO:0000269|PubMed:15215300}.
uniprot
proteins
mass_dalton
55844
uniprot
proteins
mutagenesis
MUTAGEN 255; /note="K->A: Abolishes ATPase activity."; /evidence="ECO:0000269|PubMed:15215300
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation. {ECO:0000255|HAMAP-Rule:MF_03023}.; PTM: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation. {ECO:0000255|HAMAP-Rule:MF_03023}.
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
protein_family
Katanin p60 subunit A1 subfamily
uniprot
proteins
pubmed
10209026
uniprot
proteins
pubmed
15215300
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Midbody {ECO:0000255|HAMAP-Rule:MF_03023}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole {ECO:0000255|HAMAP-Rule:MF_03023}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:O75449}. Note=Predominantly cytoplasmic. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase and telophase is localized at the midbody region. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1 (By similarity). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (By similarity). Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches (By similarity). {ECO:0000250|UniProtKB:O75449, ECO:0000255|HAMAP-Rule:MF_03023}.
uniprot
proteins