Fbxw21
entrez
320082
canonical
uniprot
Q8BI38
canonical
ensembl
ENSMUSG00000047237
resolver
ensp
ENSMUSP00000056358
resolver
ensp
ENSMUSP00000143095
resolver
enst
ENSMUST00000054925
resolver
enst
ENSMUST00000198076
resolver
genesymbol
Fbxw21
resolver
genesymbol_syn
E330009P21Rik
resolver
uniprot
A0A0G2JFA7
resolver
uniprot
K9J6U2
resolver
uniprot
Q3UWS5
resolver
uniprot_entry
A0A0G2JFA7_MOUSE
resolver
uniprot_entry
K9J6U2_MOUSE
resolver
uniprot_entry
Q3UWS5_MOUSE
resolver
uniprot_entry
Q8BI38_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: In oocytes and preimplantation embryos, SCF(Fbxw21) ubiquitin ligase complex is maintained inactive by cytoplasmic lattices. {ECO:0000269|PubMed:41917274}.
uniprot
proteins
amino_acid_sequence
MEIHLPRLPLMEIFSYLDAYSLLQVAQVNKNWNELASSDVLWRKLCQKRWFYCNMVTQQLLGKETWKEFFIYRTWQEHAKSRAKPEDFIYKEIPAEYGIQAYACYISEHGLTRNGQGRSVICMATSMNRISTWDIHEGVLTWVSPEQPASIKLLTTLPEMYIAVTVDMESTIKLWDCHNSEALATNSLISPCQSLKAVITKDGPIVLIGDTLGNLNIFRIPDLYHITRLKVFPYGISELYCSPQKKWIFLNRKHPHILPKVFYMSSLLRTSEFSAPVSTDLKFSLCQRAFWTPRREDRITLMSIHGPKKIKKFITFDMELEKIGNKITVKEHFFASFSLQNYEERPEWYGVSDKDVIVCSTRFSLLLFDINGHCLQAFQYCPEQILRLWVDPLHVIVSCNDGFLDVYAWEERSQQLNKCYRLQYSKHLPSSGLINKTLSDDVSIIQVITIRTTPCFLMAFILKSALEN
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, which mediates ubiquitination and degradation of target proteins. {ECO:0000250|UniProtKB:E9PXM9}.
uniprot
proteins
mass_dalton
54452
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:E9PXM9}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
41917274
uniprot
proteins
sequence_length
468
uniprot
proteins