SSNA1
entrez
8636
canonical
uniprot
O43805
canonical
ensembl
ENSG00000176101
resolver
ensp
ENSP00000313752
resolver
enst
ENST00000322310
resolver
genesymbol
SSNA1
resolver
genesymbol_syn
NA14
resolver
hgnc
HGNC:11321
resolver
uniprot
Q5VSG0
resolver
uniprot
Q6FG70
resolver
uniprot
Q9BVW8
resolver
uniprot_entry
SSNA1_HUMAN
resolver
uniprot_sec
Q5VSG0
resolver
uniprot_sec
Q6FG70
resolver
uniprot_sec
Q9BVW8
resolver
amino_acid_sequence
MTQQGAALQNYNNELVKCIEELCQKREELCRQIQEEEDEKQRLQNEVRQLTEKLARVNENLARKIASRNEFDRTIAETEAAYLKILESSQTLLSVLKREAGNLTKATAPDQKSSGGRDS
uniprot
proteins
function
FUNCTION: Microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage, protecting microtubules from the microtubule-severing enzyme SPAST (PubMed:34970964). Induces microtubule branching which is mediated by the formation of long SSNA1 fibrils which guide microtubule protofilaments to split apart from the mother microtubule and form daughter microtubules (By similarity). Plays a role in axon outgrowth and branching (PubMed:25390646). Required for cell division (PubMed:25390646). {ECO:0000250|UniProtKB:Q9XF62, ECO:0000269|PubMed:25390646, ECO:0000269|PubMed:34970964}.
uniprot
proteins
mass_dalton
13596
uniprot
proteins
mutagenesis
MUTAGEN 18; /note="C->S: Does not affect oligomer formation; when associated with S-23 and S-30."; /evidence="ECO:0000269|PubMed:22008182"; MUTAGEN 23; /note="C->S: Does not affect oligomer formation; when associated with S-18 and S-30."; /evidence="ECO:0000269|PubMed:22008182"; MUTAGEN 30; /note="C->S: Does not affect oligomer formation; when associated with S-18 and S-23."; /evidence="ECO:0000269|PubMed:22008182
uniprot
proteins
protein_family
SSNA1 family
uniprot
proteins
pubmed
12640030
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15269182
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22008182
uniprot
proteins
pubmed
25390646
uniprot
proteins
pubmed
34970964
uniprot
proteins
pubmed
9430706
uniprot
proteins
sequence_length
119
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9430706}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12640030, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:25390646}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:25390646}. Midbody {ECO:0000269|PubMed:25390646}. Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000269|PubMed:12640030}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:12640030}. Cell projection, axon {ECO:0000250|UniProtKB:Q9JJ94}. Note=In sperm, strongly expressed in the basal body region with weaker expression in the axoneme (PubMed:12640030). Localizes to axon branching points in neurons (By similarity). {ECO:0000250|UniProtKB:Q9JJ94, ECO:0000269|PubMed:12640030}.
uniprot
proteins