SLC15A4
entrez
121260
canonical
uniprot
Q8N697
canonical
ensembl
ENSG00000139370
resolver
ensp
ENSP00000266771
resolver
ensp
ENSP00000593449
resolver
ensp
ENSP00000715096
resolver
genesymbol
SLC15A4
resolver
genesymbol_syn
PHT1
resolver
genesymbol_syn
PTR4
resolver
hgnc
HGNC:23090
resolver
uniprot
A6H8Y9
resolver
uniprot
B3KTK1
resolver
uniprot
Q71M34
resolver
uniprot
Q7Z5F8
resolver
uniprot
Q8TAH0
resolver
uniprot_entry
S15A4_HUMAN
resolver
uniprot_sec
A6H8Y9
resolver
uniprot_sec
B3KTK1
resolver
uniprot_sec
Q71M34
resolver
uniprot_sec
Q7Z5F8
resolver
uniprot_sec
Q8TAH0
resolver
amino_acid_sequence
MEGSGGGAGERAPLLGARRAAAAAAAAGAFAGRRAACGAVLLTELLERAAFYGITSNLVLFLNGAPFCWEGAQASEALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGMLAFPLLAAPATRAALCGSARLLNCTAPGPDAAARCCSPATFAGLVLVGLGVATVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQQNVSFVTGYAIPTVCVGLAFVVFLCGQSVFITKPPDGSAFTDMFKILTYSCCSQKRSGERQSNGEGIGVFQQSSKQSLFDSCKMSHGGPFTEEKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYVLQSLHLRIPEISNITTTPHTLPAAWLTMFDAVLILLLIPLKDKLVDPILRRHGLLPSSLKRIAVGMFFVMCSAFAAGILESKRLNLVKEKTINQTIGNVVYHAADLSLWWQVPQYLLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGVGSFVGSGLLALVSIKAIGWMSSHTDFGNINGCYLNYYFFLLAAIQGATLLLFLIISVKYDHHRDHQRSRANGVPTSRRA
uniprot
proteins
function
FUNCTION: Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:16289537, PubMed:25238095, PubMed:29224352, PubMed:39719710). Preferably binds to short peptides with a basic residue at the first position and a hydrophobic residue at the second position (PubMed:39719710). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29224352, PubMed:31073693). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:25238095, PubMed:29224352). Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:25238095). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (PubMed:32433612, PubMed:39719710). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (By similarity). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity). {ECO:0000250|UniProtKB:O09014, ECO:0000250|UniProtKB:Q91W98, ECO:0000269|PubMed:16289537, ECO:0000269|PubMed:25238095, ECO:0000269|PubMed:29224352, ECO:0000269|PubMed:31073693, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:39719710}.
uniprot
proteins
mass_dalton
62034
uniprot
proteins
mutagenesis
MUTAGEN 14..15; /note="LL->AA: Abolished localization to the lysosome membrane and promotes relocalization to the plasma membrane; when associated with 318-A-A-319. Does not affect interaction with TASL."; /evidence="ECO:0000269|PubMed:29224352, ECO:0000269|PubMed:32433612"; MUTAGEN 44; /note="E->A: Does not affect interaction with TASL."; /evidence="ECO:0000269|PubMed:32433612"; MUTAGEN 47; /note="E->A: Does not affect interaction with TASL."; /evidence="ECO:0000269|PubMed:32433612"; MUTAGEN 318..319; /note="LV->AA: Abolished localization to the lysosome membrane and promotes relocalization to the plasma membrane; when associated with 14-A-A-15."; /evidence="ECO:0000269|PubMed:29224352"; MUTAGEN 465; /note="E->K: Abolished transmembrane transporter activity. Abolished interaction with TASL."; /evidence="ECO:0000269|PubMed:25238095, ECO:0000269|PubMed:32433612
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family
uniprot
proteins
pubmed
11741232
uniprot
proteins
pubmed
11741260
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16289537
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25238095
uniprot
proteins
pubmed
29224352
uniprot
proteins
pubmed
31073693
uniprot
proteins
pubmed
32433612
uniprot
proteins
pubmed
39719710
uniprot
proteins
sequence_length
577
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:25238095, ECO:0000269|PubMed:29224352, ECO:0000269|PubMed:32433612}; Multi-pass membrane protein {ECO:0000269|PubMed:39719710}. Endosome membrane {ECO:0000269|PubMed:32433612}; Multi-pass membrane protein {ECO:0000269|PubMed:39719710}. Early endosome membrane {ECO:0000250|UniProtKB:Q91W98}; Multi-pass membrane protein {ECO:0000269|PubMed:39719710}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..62; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX3, ECO:0007744|PDB:8WX4, ECO:0007744|PDB:8WX5"; TRANSMEM 77..96; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX3, ECO:0007744|PDB:8WX4, ECO:0007744|PDB:8WX5"; TRANSMEM 105..125; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX3, ECO:0007744|PDB:8WX4, ECO:0007744|PDB:8WX5"; TRANSMEM 156..176; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX3, ECO:0007744|PDB:8WX4, ECO:0007744|PDB:8WX5"; TRANSMEM 194..216; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX3, ECO:0007744|PDB:8WX4, ECO:0007744|PDB:8WX5"; TRANSMEM 223..243; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX3, ECO:0007744|PDB:8WX4, ECO:0007744|PDB:8WX5"; TRANSMEM 317..338; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX3, ECO:0007744|PDB:8WX4, ECO:0007744|PDB:8WX5"; TRANSMEM 367..392; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX3, ECO:0007744|PDB:8WX4, ECO:0007744|PDB:8WX5"; TRANSMEM 405..422; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX3, ECO:0007744|PDB:8WX4, ECO:0007744|PDB:8WX5"; TRANSMEM 455..475; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX3, ECO:0007744|PDB:8WX4, ECO:0007744|PDB:8WX5"; TRANSMEM 487..510; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX3, ECO:0007744|PDB:8WX4, ECO:0007744|PDB:8WX5"; TRANSMEM 536..553; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX3, ECO:0007744|PDB:8WX4, ECO:0007744|PDB:8WX5
uniprot
proteins