GSPT2
entrez
23708
canonical
uniprot
Q8IYD1
canonical
ensembl
ENSG00000189369
resolver
ensp
ENSP00000341247
resolver
enst
ENST00000340438
resolver
genesymbol
GSPT2
resolver
genesymbol_syn
ERF3B
resolver
hgnc
HGNC:4622
resolver
uniprot
Q9H909
resolver
uniprot
Q9NVY0
resolver
uniprot
Q9NY44
resolver
uniprot_entry
ERF3B_HUMAN
resolver
uniprot_sec
Q9H909
resolver
uniprot_sec
Q9NVY0
resolver
uniprot_sec
Q9NY44
resolver
amino_acid_sequence
MDSGSSSSDSAPDCWDQVDMESPGSAPSGDGVSSAVAEAQREPLSSAFSRKLNVNAKPFVPNVHAAEFVPSFLRGPTQPPTLPAGSGSNDETCTGAGYPQGKRMGRGAPVEPSREEPLVSLEGSNSAVTMELSEPVVENGEVEMALEESWEHSKEVSEAEPGGGSSGDSGPPEESGQEMMEEKEEIRKSKSVIVPSGAPKKEHVNVVFIGHVDAGKSTIGGQIMFLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETERKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSIERYEECKEKLVPFLKKVGFSPKKDIHFMPCSGLTGANIKEQSDFCPWYTGLPFIPYLDNLPNFNRSIDGPIRLPIVDKYKDMGTVVLGKLESGSIFKGQQLVMMPNKHNVEVLGILSDDTETDFVAPGENLKIRLKGIEEEEILPGFILCDPSNLCHSGRTFDVQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALISLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:11524954, PubMed:15987998, PubMed:17562865). GSPT2/ERF3B mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:15987998). GTP hydrolysis by GSPT2/ERF3B induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (PubMed:15987998). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). {ECO:0000269|PubMed:11524954, ECO:0000269|PubMed:15987998, ECO:0000269|PubMed:17562865, ECO:0000269|PubMed:19417104}.
uniprot
proteins
mass_dalton
68883
uniprot
proteins
mutagenesis
MUTAGEN 52; /note="L->K: Impairs interaction with UPF1 and PABPC1; when associated with A-55, K-56 and A-59."; /evidence="ECO:0000269|PubMed:18447585"; MUTAGEN 55; /note="N->A: Impairs interaction with UPF1 and PABPC1; when associated with K-52, K-56 and A-59."; /evidence="ECO:0000269|PubMed:18447585"; MUTAGEN 56; /note="A->K: Impairs interaction with UPF1 and PABPC1; when associated with K52, A-55, and A-59."; /evidence="ECO:0000269|PubMed:18447585"; MUTAGEN 59; /note="F->A: Impairs interaction with UPF1 and PABPC1; when associated with K-52, A-55 and K-56."; /evidence="ECO:0000269|PubMed:18447585
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
ERF3 subfamily
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
11524954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
15987998
uniprot
proteins
pubmed
16721809
uniprot
proteins
pubmed
17562865
uniprot
proteins
pubmed
18447585
uniprot
proteins
pubmed
19417104
uniprot
proteins
pubmed
20418951
uniprot
proteins
pubmed
21269460
uniprot
proteins
sequence_length
628
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins