RRAS2
entrez
22800
canonical
uniprot
P62070
canonical
ensembl
ENSG00000133818
resolver
ensp
ENSP00000256196
resolver
ensp
ENSP00000403282
resolver
ensp
ENSP00000431954
resolver
ensp
ENSP00000434104
resolver
ensp
ENSP00000437547
resolver
genesymbol
RRAS2
resolver
genesymbol_syn
TC21
resolver
hgnc
HGNC:17271
resolver
uniprot
B2R9Z3
resolver
uniprot
B7Z5Z2
resolver
uniprot
B7Z6C4
resolver
uniprot
B7Z7H6
resolver
uniprot
P17082
resolver
uniprot_entry
RRAS2_HUMAN
resolver
uniprot_sec
B2R9Z3
resolver
uniprot_sec
B7Z5Z2
resolver
uniprot_sec
B7Z6C4
resolver
uniprot_sec
B7Z7H6
resolver
uniprot_sec
P17082
resolver
amino_acid_sequence
MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQEQECPPSPEPTRKEKDKKGCHCVIF
uniprot
proteins
disease_involvement
DISEASE: Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. {ECO:0000269|PubMed:8052619}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Noonan syndrome 12 (NS12) [MIM:618624]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. NS12 inheritance is autosomal dominant. There is considerable variability in severity. {ECO:0000269|PubMed:31130282, ECO:0000269|PubMed:31130285}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: GTP-binding protein with GTPase activity, involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (PubMed:31130282, PubMed:31130285, PubMed:39809765). Regulates craniofacial development (PubMed:31130282, PubMed:31130285). {ECO:0000269|PubMed:31130282, ECO:0000269|PubMed:31130285, ECO:0000269|PubMed:39809765}.
uniprot
proteins
mass_dalton
23400
uniprot
proteins
mutagenesis
MUTAGEN 192..197; /note="KEKDKK->RERDRR: Strongly decreased lysine fatty-acylation."; /evidence="ECO:0000269|PubMed:28406396"; MUTAGEN 199; /note="C->S: Does not affect lysine fatty-acylation."; /evidence="ECO:0000269|PubMed:28406396
uniprot
proteins
post_translational_modification
PTM: May be post-translationally modified by both palmitoylation and polyisoprenylation. {ECO:0000269|PubMed:15308774}.; PTM: Fatty-acylation at Lys-192, Lys-194; lys-196 and Lys-197 is required for localization to the plasma membrane and activity (PubMed:28406396). Defatty-acylated by SIRT6, affecting its localization to the plasma membrane (PubMed:28406396). {ECO:0000269|PubMed:28406396}.
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15308774
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
2108320
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28406396
uniprot
proteins
pubmed
31130282
uniprot
proteins
pubmed
31130285
uniprot
proteins
pubmed
39809765
uniprot
proteins
pubmed
8052619
uniprot
proteins
sequence_length
204
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28406396, ECO:0000269|PubMed:31130282}; Lipid-anchor {ECO:0000269|PubMed:15308774, ECO:0000269|PubMed:28406396}; Cytoplasmic side. Golgi apparatus membrane {ECO:0000269|PubMed:31130282}; Lipid-anchor {ECO:0000269|PubMed:15308774}.
uniprot
proteins