Q99PW3
uniprot
Q99PW3
canonical
amino_acid_sequence
MVGAEPSRPPGPPSYWTGRRGQGLAAIFLLLVSAAGSEARTEDDFSLVQPLVTMEQLLWVSGKQIGSVDTFRIPLITATPRGTLLAFAEARKKSASDEGAKFIAMRRSTDQGSTWSSTAFIVDDGEASDGLNLGAVVNDVDTGVVFLIYTLCAHKVNCQVASTMLVWSKDDGVSWSPPRNLSVDIGTEMFAPGPGSGIQKQREPWKGRLIVCGHGTLERDGVFCLLSDDHGASWHYGTGVSGIPFGQPKHDHDFNPDECQPYELPDGSVIINARNQNNYHCRCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGALATSSGIVFFSNPAHPEYRVNLTLRWSFSNGTFWQKERVQLWPGPSGYSSLTALENSTDGKKQPPQLFVLYEKGLNRYTESISMVKISVYGTL
uniprot
proteins
ec_number
3.2.1.18
uniprot
proteins
function
FUNCTION: Lysosomal exo-alpha-sialidase that catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269|PubMed:11162581}.
uniprot
proteins
mass_dalton
44695
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q99519}.; PTM: Phosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane. {ECO:0000250|UniProtKB:Q99519}.
uniprot
proteins
protein_family
Glycosyl hydrolase 33 family
uniprot
proteins
pubmed
11162581
uniprot
proteins
sequence_length
409
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome lumen {ECO:0000269|PubMed:11162581}. Lysosome membrane {ECO:0000269|PubMed:11162581}; Peripheral membrane protein {ECO:0000305|PubMed:11162581}; Lumenal side {ECO:0000305|PubMed:11162581}. Cell membrane {ECO:0000269|PubMed:11162581}; Peripheral membrane protein {ECO:0000305|PubMed:11162581}. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles. Was also suggested to have transmembrane topology. {ECO:0000250|UniProtKB:Q99519}.
uniprot
proteins