Chrm2
entrez
243764
canonical
uniprot
Q9ERZ4
canonical
ensembl
ENSMUSG00000045613
resolver
ensp
ENSMUSP00000130874
resolver
ensp
ENSMUSP00000280276
resolver
ensp
ENSMUSP00000280277
resolver
ensp
ENSMUSP00000280280
resolver
enst
ENSMUST00000172278
resolver
genesymbol
Chrm2
resolver
genesymbol_syn
Chrm-2
resolver
uniprot
E9Q9P0
resolver
uniprot_entry
ACM2_MOUSE
resolver
uniprot_sec
E9Q9P0
resolver
amino_acid_sequence
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGGTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDDNSRQTCIKIVTKTQKGDACTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
uniprot
proteins
function
FUNCTION: Muscarinic receptor for acetylcholine, a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. CHRM2 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G proteins and mediates signaling by inhibiting adenylate cyclase activity. {ECO:0000250|UniProtKB:P08172}.
uniprot
proteins
mass_dalton
51499
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of the P-X-P-P motif promotes association with beta-arrestin (ARRB1 and/or ARRB2), leading to receptor desensitization and negative regulation of G protein-coupled receptor signaling. {ECO:0000250|UniProtKB:P08172}.
uniprot
proteins
protein_family
CHRM2 sub-subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Muscarinic acetylcholine receptor subfamily
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08172}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08172}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P08172}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08172}. Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250|UniProtKB:P06199}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..46; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P08172"; TRANSMEM 61..85; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P08172"; TRANSMEM 93..119; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P08172"; TRANSMEM 141..162; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P08172"; TRANSMEM 183..207; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P08172"; TRANSMEM 388..412; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P08172"; TRANSMEM 420..442; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P08172
uniprot
proteins