ACP4
entrez
93650
canonical
uniprot
Q9BZG2
canonical
ensembl
ENSG00000142513
resolver
ensp
ENSP00000270593
resolver
genesymbol
ACP4
resolver
genesymbol_syn
ACPT
resolver
hgnc
HGNC:14376
resolver
uniprot
C0H3P7
resolver
uniprot
Q9BZG3
resolver
uniprot
Q9BZG4
resolver
uniprot_entry
PPAT_HUMAN
resolver
uniprot_sec
C0H3P7
resolver
uniprot_sec
Q9BZG3
resolver
uniprot_sec
Q9BZG4
resolver
amino_acid_sequence
MAGLGFWGHPAGPLLLLLLLVLPPRALPEGPLVFVALVFRHGDRAPLASYPMDPHKEVASTLWPRGLGQLTTEGVRQQLELGRFLRSRYEAFLSPEYRREEVYIRSTDFDRTLESAQANLAGLFPEAAPGSPEARWRPIPVHTVPVAEDKLLRFPMRSCPRYHELLREATEAAEYQEALEGWTGFLSRLENFTGLSLVGEPLRRAWKVLDTLMCQQAHGLPLPAWASPDVLRTLAQISALDIGAHVGPPRAAEKAQLTGGILLNAILANFSRVQRLGLPLKMVMYSAHDSTLLALQGALGLYDGHTPPYAACLGFEFRKHLGNPAKDGGNVTVSLFYRNDSAHLPLPLSLPGCPAPCPLGRFYQLTAPARPPAHGVSCHGPYEAAIPPAPVVPLLAGAVAVLVALSLGLGLLAWRPGCLRALGGPV
uniprot
proteins
disease_involvement
DISEASE: Amelogenesis imperfecta 1J (AI1J) [MIM:617297]: A form of amelogenesis imperfecta, a disorder characterized by defective enamel formation. The enamel may be hypoplastic, hypomineralized or both, and affected teeth may be discolored, sensitive or prone to disintegration. AI1J is an autosomal recessive form characterized by hypoplastic enamel, enamel discolorization ranging from yellow to black, and normal dentin. {ECO:0000269|PubMed:27843125}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Protein tyrosine phosphatase that dephosphorylates the receptor tyrosine-protein kinase ERBB4, thereby inhibiting its ligand-induced proteolytic cleavage (PubMed:15219672). Involved in odontogenesis (PubMed:27843125). Regulates odontoblast cell fate via its extracellular catalytic domain by inhibiting proliferation and promoting differentiation (By similarity). {ECO:0000250|UniProtKB:D3YTS9, ECO:0000269|PubMed:15219672, ECO:0000269|PubMed:27843125}.
uniprot
proteins
mass_dalton
46090
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000305|PubMed:15219672}.
uniprot
proteins
protein_family
Histidine acid phosphatase family
uniprot
proteins
pubmed
11414767
uniprot
proteins
pubmed
15219672
uniprot
proteins
pubmed
27843125
uniprot
proteins
sequence_length
426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 394..414; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins