Pold4
entrez
69745
canonical
uniprot
Q9CWP8
canonical
ensembl
ENSMUSG00000024854
resolver
ensp
ENSMUSP00000025773
resolver
enst
ENSMUST00000025773
resolver
genesymbol
Pold4
resolver
uniprot
Q547B4
resolver
uniprot_entry
DPOD4_MOUSE
resolver
uniprot_entry
Q547B4_MOUSE
resolver
amino_acid_sequence
MGRKRFITDSYPVVKKREGPPGHSKGELAPELGEDTQSLSQEETELELLRQFDLAWQYGPCTGITRLQRWSRAEQMGLKPPLEVYQVLKAHPEDPHFQCSLWHLYPL
uniprot
proteins
function
FUNCTION: As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity. Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb. Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites. Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival. {ECO:0000250|UniProtKB:Q9HCU8}.
uniprot
proteins
mass_dalton
12403
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination in response to UV irradiation or treatment with an alkylating agent, leading to proteasomal degradation. This modification is mediated, at least in part, by RNF8. {ECO:0000269|PubMed:23233665}.; PTM: Ubiquitinated; undergoes 'Lys-48'-linked ubiquitination in response to UV irradiation, leading to proteasomal degradation. This modification is partly mediated by RNF8 and by the DCX(DTL) E3 ubiquitin ligase complex (also called CRL4(CDT2)). Efficient degradation requires the presence of PCNA and is required for the inhibition of fork progression after DNA damage. {ECO:0000250|UniProtKB:Q9HCU8}.
uniprot
proteins
protein_family
DNA polymerase delta subunit 4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23233665
uniprot
proteins
sequence_length
107
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9HCU8}. Note=Partially recruited to DNA damage sites within 2 hours following UV irradiation, before degradation. {ECO:0000250|UniProtKB:Q9HCU8}.
uniprot
proteins