Kcnj6
entrez
16522
canonical
uniprot
P48542
canonical
ensembl
ENSMUSG00000043301
resolver
ensp
ENSMUSP00000093558
resolver
ensp
ENSMUSP00000097108
resolver
ensp
ENSMUSP00000130321
resolver
ensp
ENSMUSP00000156014
resolver
enst
ENSMUST00000095873
resolver
enst
ENSMUST00000099508
resolver
enst
ENSMUST00000165538
resolver
enst
ENSMUST00000232562
resolver
genesymbol
Kcnj6
resolver
genesymbol_syn
Girk2
resolver
genesymbol_syn
Kcnj7
resolver
genesymbol_syn
W
resolver
uniprot
A0A0R4J239
resolver
uniprot
A0A338P6L0
resolver
uniprot
F7C460
resolver
uniprot
F7CNX7
resolver
uniprot
O70290
resolver
uniprot
P70216
resolver
uniprot
P70306
resolver
uniprot
P70307
resolver
uniprot
P70308
resolver
uniprot
P70309
resolver
uniprot
P70454
resolver
uniprot
Q0VB45
resolver
uniprot
Q8C4T8
resolver
uniprot
Q8C8Y6
resolver
uniprot
Q9QYH5
resolver
uniprot_entry
A0A0R4J239_MOUSE
resolver
uniprot_entry
A0A338P6L0_MOUSE
resolver
uniprot_entry
F7C460_MOUSE
resolver
uniprot_entry
F7CNX7_MOUSE
resolver
uniprot_entry
KCNJ6_MOUSE
resolver
uniprot_entry
Q0VB45_MOUSE
resolver
uniprot_entry
Q8C4T8_MOUSE
resolver
uniprot_entry
Q8C8Y6_MOUSE
resolver
uniprot_sec
O70290
resolver
uniprot_sec
P70216
resolver
uniprot_sec
P70306
resolver
uniprot_sec
P70307
resolver
uniprot_sec
P70308
resolver
uniprot_sec
P70309
resolver
uniprot_sec
P70454
resolver
uniprot_sec
Q9QYH5
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2). {ECO:0000250|UniProtKB:P48550}.
uniprot
proteins
amino_acid_sequence
MTMAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQSDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGIVEATGMTCQARSSYITSEILWGYRFTPVLTMEDGFYEVDYNSFHETYETSTPSLSAKELAELANRAEVPLSWSVSSKLNQHAELETEEEEKNPEELTERNGDVANLENESKV
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Kcnj6 are the cause of the weaver (wv) phenotype. Homozygous animals suffer from severe ataxia that is obvious by about the second postnatal week. The cerebellum of these animals is drastically reduced in size due to depletion of the major cell type of cerebellum, the granule cell neuron. Heterozygous animals are not ataxic but have an intermediate number of surviving granule cells. Male homozygotes are sterile, because of complete failure of sperm production. Both hetero- and homozygous animals undergo sporadic tonic-clonic seizures. {ECO:0000269|PubMed:7550338}.
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins (By similarity). Forms a functional channel in association with KCNJ3/GIRK1 (PubMed:10341034). {ECO:0000250|UniProtKB:P48051, ECO:0000269|PubMed:10341034}.; FUNCTION: [Isoform GIRK2-1]: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins. {ECO:0000269|PubMed:7499385, ECO:0000269|PubMed:7926018}.; FUNCTION: [Isoform GIRK2B]: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins. {ECO:0000269|PubMed:8573147}.; FUNCTION: [Isoform GIRK2D]: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins. {ECO:0000269|PubMed:10562331}.
uniprot
proteins
mass_dalton
48652
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ6 subfamily
uniprot
proteins
pubmed
10341034
uniprot
proteins
pubmed
10562331
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7499385
uniprot
proteins
pubmed
7550338
uniprot
proteins
pubmed
7926018
uniprot
proteins
pubmed
8573147
uniprot
proteins
pubmed
9721208
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform GIRK2D]: Membrane {ECO:0000269|PubMed:10562331}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 92..116; /note="Helical; Name=M1"; /evidence="ECO:0000250"; TRANSMEM 169..190; /note="Helical; Name=M2"; /evidence="ECO:0000250
uniprot
proteins