SRCIN1
entrez
80725
canonical
uniprot
Q9C0H9
canonical
ensembl
ENSG00000273608
resolver
ensembl
ENSG00000277363
resolver
ensp
ENSP00000484715
resolver
genesymbol
SRCIN1
resolver
genesymbol_syn
KIAA1684
resolver
genesymbol_syn
P140
resolver
genesymbol_syn
SNIP
resolver
hgnc
HGNC:29506
resolver
uniprot
Q75T46
resolver
uniprot
Q8N4W8
resolver
uniprot_entry
SRCN1_HUMAN
resolver
uniprot_sec
Q75T46
resolver
uniprot_sec
Q8N4W8
resolver
amino_acid_sequence
MGNAPSQDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNSSISF
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. {ECO:0000269|PubMed:14657239, ECO:0000269|PubMed:17525734, ECO:0000269|PubMed:19146815}.
uniprot
proteins
mass_dalton
127105
uniprot
proteins
post_translational_modification
PTM: Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands. {ECO:0000269|PubMed:14657239}.
uniprot
proteins
protein_family
SRCIN1 family
uniprot
proteins
pubmed
11214970
uniprot
proteins
pubmed
14657239
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17525734
uniprot
proteins
pubmed
18475297
uniprot
proteins
pubmed
18662323
uniprot
proteins
pubmed
19146815
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
1183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QXY2}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QXY2}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QXY2}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9QXY2}. Presynapse {ECO:0000250|UniProtKB:Q9QXY2}. Postsynapse {ECO:0000250|UniProtKB:Q9QXY2}. Postsynaptic density {ECO:0000250|UniProtKB:Q9QXY2}. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions. {ECO:0000250|UniProtKB:Q9QXY2}.
uniprot
proteins