REPS2
entrez
9185
canonical
uniprot
Q8NFH8
canonical
ensembl
ENSG00000169891
resolver
ensp
ENSP00000306033
resolver
ensp
ENSP00000349824
resolver
ensp
ENSP00000526289
resolver
ensp
ENSP00000526290
resolver
ensp
ENSP00000526291
resolver
ensp
ENSP00000526292
resolver
ensp
ENSP00000596510
resolver
ensp
ENSP00000612376
resolver
ensp
ENSP00000790495
resolver
genesymbol
REPS2
resolver
genesymbol_syn
POB1
resolver
hgnc
HGNC:9963
resolver
uniprot
A6PWZ6
resolver
uniprot
O43428
resolver
uniprot
Q5JNZ8
resolver
uniprot
Q8NFI5
resolver
uniprot_entry
REPS2_HUMAN
resolver
uniprot_sec
A6PWZ6
resolver
uniprot_sec
O43428
resolver
uniprot_sec
Q5JNZ8
resolver
uniprot_sec
Q8NFI5
resolver
amino_acid_sequence
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLHQITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSYPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDSNSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQSEQVSEAELLPQLSRAPSQAAESSPAKKDVLYSQPPSKPIRRKFRPENQATENQEPSTAASGPASAATMKPHPTVQKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKEVHQERIALENQLEQLRPVTVL
uniprot
proteins
function
FUNCTION: Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}.
uniprot
proteins
mass_dalton
71534
uniprot
proteins
mutagenesis
MUTAGEN 562; /note="P->A: Abolishes interaction with ASAP1."; /evidence="ECO:0000269|PubMed:12149250"; MUTAGEN 565; /note="P->A: Abolishes interaction with ASAP1."; /evidence="ECO:0000269|PubMed:12149250
uniprot
proteins
post_translational_modification
PTM: Tyrosine-phosphorylated upon stimulation of cells with EGF. Phosphorylation on Tyr-residues induces its association with the EGF receptor probably indirectly through an adapter like GRB2. {ECO:0000269|PubMed:9422736}.
uniprot
proteins
pubmed
10393179
uniprot
proteins
pubmed
10557078
uniprot
proteins
pubmed
12149250
uniprot
proteins
pubmed
12771942
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
23033978
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9422736
uniprot
proteins
pubmed
9928989
uniprot
proteins
sequence_length
660
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12771942}.
uniprot
proteins