Hcrt
entrez
25723
canonical
uniprot
O55232
canonical
ensembl
ENSRNOG00000018892
resolver
ensembl
ENSRNOG00055033322
resolver
ensembl
ENSRNOG00060028629
resolver
ensembl
ENSRNOG00065028475
resolver
ensp
ENSRNOP00000025547
resolver
ensp
ENSRNOP00055047497
resolver
ensp
ENSRNOP00060041514
resolver
ensp
ENSRNOP00065040244
resolver
enst
ENSRNOT00000025547
resolver
enst
ENSRNOT00055057605
resolver
enst
ENSRNOT00060049791
resolver
enst
ENSRNOT00065049071
resolver
genesymbol
Hcrt
resolver
genesymbol_syn
Ox
resolver
genesymbol_syn
Ppox
resolver
uniprot_entry
OREX_RAT
resolver
amino_acid_sequence
MNLPSTKVPWAAVTLLLLLLLPPALLSLGVDAQPLPDCCRQKTCSCRLYELLHGAGNHAAGILTLGKRRPGPPGLQGRLQRLLQANGNHAAGILTMGRRAGAELEPYPCPGRRCPTATATALAPRGGSRV
uniprot
proteins
function
FUNCTION: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions (PubMed:11283317, PubMed:11340621, PubMed:9491897). A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested (PubMed:9491897). A modulation effect on luteinizing hormone-releasing hormone (LHRH) secretion also suggests a more minor contribution to the regulation of reproductive function (PubMed:11340621, PubMed:9879756). {ECO:0000269|PubMed:9491897, ECO:0000269|PubMed:9879756, ECO:0000303|PubMed:11283317, ECO:0000303|PubMed:11340621}.; FUNCTION: [Orexin-A]: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (PubMed:9491897). Stimulates food intake (PubMed:9491897). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (PubMed:9879756). {ECO:0000269|PubMed:9491897, ECO:0000269|PubMed:9879756}.; FUNCTION: [Orexin-B]: Binds to orexin receptor HCRTR2/OX2R only (PubMed:9491897). Stimulates food intake (PubMed:9491897). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (PubMed:9879756). {ECO:0000269|PubMed:9491897, ECO:0000269|PubMed:9879756}.
uniprot
proteins
mass_dalton
13645
uniprot
proteins
post_translational_modification
PTM: Specific enzymatic cleavages at paired basic residues yield the different active peptides. {ECO:0000303|PubMed:9491897}.
uniprot
proteins
protein_family
Orexin family
uniprot
proteins
pubmed
11283317
uniprot
proteins
pubmed
11340621
uniprot
proteins
pubmed
9419374
uniprot
proteins
pubmed
9491897
uniprot
proteins
pubmed
9879756
uniprot
proteins
sequence_length
130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Rough endoplasmic reticulum {ECO:0000269|PubMed:9419374}. Cytoplasmic vesicle {ECO:0000269|PubMed:9419374}. Synapse {ECO:0000269|PubMed:9419374}. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000269|PubMed:9419374}.
uniprot
proteins