Q9Z2C8
uniprot
Q9Z2C8
canonical
amino_acid_sequence
MSEAEASVVATAAPAATVPATAAGVVAVVVPVPAGEPQKAGGGAGGGGGAASGPAAGTPLHAPGPRTPGNQATAASGTPAPPARSQADKPVLAIQVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKRNNPRKFLRSVGDGETVEFDVVEGEKGARAANVTGPGGVPVKGSRYAPNRRRFRRFIPRPRPAAPPPMVAEAPSGGTEPGSEGERAEDSGQRPRRRRPPPFFYRRRFVRGPRPPNQQQPIEGSDGVEPKETAPLEGDQQQGDERVPPPRFRPRYRRPFRPRPPQQPTTEGGDGETKPSQGPTDGSRPEPQRPRNRPYFQRRRQQPPGPRQPIAAETSAPINSGDPPTTILE
uniprot
proteins
function
FUNCTION: Major constituent of messenger ribonucleoprotein particles (mRNPs) (PubMed:10076007, PubMed:12297523, PubMed:12648488). Involved in the regulation of the stability and/or translation of germ cell mRNAs (PubMed:15031116). Binds to Y-box consensus promoter element (PubMed:10076007, PubMed:12297523, PubMed:12648488). Binds to full-length mRNA with high affinity in a sequence-independent manner (PubMed:10076007, PubMed:12297523, PubMed:12648488). Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity (PubMed:10076007, PubMed:12297523, PubMed:12648488). Its binding with maternal mRNAs is necessary for its cytoplasmic retention (PubMed:10076007, PubMed:12297523, PubMed:12648488). May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (PubMed:15665108). {ECO:0000269|PubMed:10076007, ECO:0000269|PubMed:12297523, ECO:0000269|PubMed:12648488, ECO:0000269|PubMed:15031116, ECO:0000269|PubMed:15665108}.
uniprot
proteins
mass_dalton
38271
uniprot
proteins
mutagenesis
MUTAGEN 109; /note="Y->A: Abolishes cytoplasmic retention and mRNA-binding affinity; when associated with A-111."; /evidence="ECO:0000269|PubMed:12648488"; MUTAGEN 111; /note="F->A: Abolishes cytoplasmic retention and mRNA-binding affinity; when associated with A-109."; /evidence="ECO:0000269|PubMed:12648488
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during oocyte maturation and dephosphorylated following egg activation. Phosphorylated in vitro by a kinase activity associated with testicular mRNPs. Dephosphorylation leads to a decrease in its affinity to bind RNA in vitro. {ECO:0000269|PubMed:10076007, ECO:0000269|PubMed:11566752}.
uniprot
proteins
pubmed
10076007
uniprot
proteins
pubmed
10772793
uniprot
proteins
pubmed
11564883
uniprot
proteins
pubmed
11566752
uniprot
proteins
pubmed
12297523
uniprot
proteins
pubmed
12648488
uniprot
proteins
pubmed
15031116
uniprot
proteins
pubmed
15665108
uniprot
proteins
pubmed
15824319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31598710
uniprot
proteins
pubmed
9780336
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11566752}. Nucleus {ECO:0000269|PubMed:11566752}.
uniprot
proteins