Ern2
entrez
26918
canonical
uniprot
Q9Z2E3
canonical
ensembl
ENSMUSG00000030866
resolver
ensp
ENSMUSP00000033153
resolver
ensp
ENSMUSP00000145716
resolver
enst
ENSMUST00000033153
resolver
enst
ENSMUST00000206198
resolver
genesymbol
Ern2
resolver
genesymbol_syn
Ire2
resolver
uniprot
A0A0U1RNV3
resolver
uniprot
Q32MS5
resolver
uniprot
Q3U5E3
resolver
uniprot
Q3UTN5
resolver
uniprot_entry
A0A0U1RNV3_MOUSE
resolver
uniprot_entry
ERN2_MOUSE
resolver
uniprot_entry
Q32MS5_MOUSE
resolver
uniprot_entry
Q3UTN5_MOUSE
resolver
uniprot_sec
Q3U5E3
resolver
activity_regulation
ACTIVITY REGULATION: The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain (By similarity). {ECO:0000250|UniProtKB:O75460}.
uniprot
proteins
amino_acid_sequence
MARPVQRFQLWSPLGFLLQLVTLLGKLGPQVQSVRPESLLFVSTLDGSLHALNKQTGDLKWTVKDDPIIQGPMYVTEMAFLSDPADGSLYVLGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTEGLSTPQLFIGRTQYTVSMHDLRTPALRWNTTYRRYSAPLLNGSPGKYMSHLTSCGMGLLLTVDPGSGIVLWTQDLGVPVTGIYTWHQDGLHQLPHLTLARDTLHFLVLRWGHIRLPASSYQDTATQFSSLDTQLLMTLYVGKEEAGFYVSKALVHAGVALVPRGLTLAPMDGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGYHEPPPVLHTTMLRVHPIPGKVSAETRASEDLHAPPVFFELLNLRREDPELHPEEKASDSYPGLGSQDLLAATFTAILLGAWVLYLMRQQQQSPSAPAGPPDLSQDAQGQLSRDILQDQRRFQSPSEPAQPPHDPEAGQPTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTEHGPQFHYIALELCQASLQEYVESPDLDRWGLEPTTVLQQMMSGLAHLHSLHIVHRDLKPANILMAGPDSQGQGRVVISDFGLCKKLPVGRCSFSLHSGIPGTEGWMAPELLQLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGESLYRQANILSGDPCLAQLQEETHDKVVALDLVRAMLSLLPQDRPSAGWVLAHPLFWSRAKELQFFQDVSDWLEKEPDQGPLVSALEAGSYKVVREDWHKHISAPLQADLKRFRSYKGTSVRDLLRAMRNKKHHYRELPAEVRQTLGQLPAGFIQYFTQRFPRLLLHTHRAMRTCASESLFLPYYPPALEARRPDATKS
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
3.1.26.-
uniprot
proteins
function
FUNCTION: Role in expression of the DDIT3 transcription factor, required for the unfolded-protein response, growth arrest and apoptosis. Has no effect on 28S ribosomal RNA cleavage, unlike the corresponding human protein. {ECO:0000269|PubMed:9755171}.
uniprot
proteins
mass_dalton
101262
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000250|UniProtKB:O75460}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9755171
uniprot
proteins
sequence_length
911
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9755171}; Single-pass type I membrane protein {ECO:0000269|PubMed:9755171}.
uniprot
proteins
transmembrane_region
TRANSMEM 427..447; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins