Gpr15
entrez
71223
canonical
uniprot
Q0VDU3
canonical
ensembl
ENSMUSG00000047293
resolver
ensp
ENSMUSP00000086731
resolver
enst
ENSMUST00000089318
resolver
genesymbol
Gpr15
resolver
uniprot
E9QKY6
resolver
uniprot
Q3B800
resolver
uniprot_entry
GPR15_MOUSE
resolver
uniprot_sec
E9QKY6
resolver
uniprot_sec
Q3B800
resolver
amino_acid_sequence
MEPATALLIVDYYDYTSPDPPFLETPSHLSYTSVFLPIFYTVVFLTGVVGNFILMIALHFKRGNRRLIDIFIINLAASDFIFLVTVPLWMDKEASLGLWRTGSFLCKGSSYVISVNMHCSVFLLTCMSMDRYLAIMHPALAKRLRRRSSAYAVCAVVWIISCVLGLPTLLSRELTHIEGKPYCAEKKPTSLKLMWGLVALITTFFVPLLSIVTCYCCITRRLCAHYQQSGKHNKKLKKSIKIVIIAVAAFTVSWVPFNTFKLLAIVSGFQPEGLFHSEALQLAMNVTGPLAFASSCVNPLIYYVFDSYIRRAIVRCLCPCLKTHNFGSSTETSDSHLTKALSNFIHAEDFIRRRKRSVSL
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that plays an important role in immune homeostasis. Acts via its natural ligand GPR15LG, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues. GPR15-GPR15LG signaling axis regulates intestinal homeostasis and inflammation through the migration of immune cells (By similarity). Controls thereby the specific homing of T-cells, particularly FOXP3+ regulatory T-cells (Tregs), to the large intestine lamina propria (PubMed:23661644). Also required for skin localization of thymus-derived dendritic epidermal T-cells (PubMed:24838826). Plays an important role in mediating cytoprotective function as well as angiogenesis of thrombomodulin (PubMed:28386128). Mechanistically, preferentially signals through the Gi/o pathway to inhibit adenylate cyclase activity and activate a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (By similarity). {ECO:0000250|UniProtKB:P49685, ECO:0000269|PubMed:23661644, ECO:0000269|PubMed:24838826, ECO:0000269|PubMed:28386128}.
uniprot
proteins
mass_dalton
40542
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is necessary for YWHAE binding and efficient surface expression. {ECO:0000250|UniProtKB:P49685}.; PTM: O-glycosylated. Sialylated O-glycans in the N-terminal tail inhibits binding of GPR15LG. {ECO:0000250|UniProtKB:P49685}.; PTM: Sulfation is required for efficient binding of GPR15LG. {ECO:0000250|UniProtKB:P49685}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23661644
uniprot
proteins
pubmed
24838826
uniprot
proteins
pubmed
28386128
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P49685}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P49685}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 70..90; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 121..141; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 240..260; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 285..305; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins