GGH
entrez
8836
canonical
uniprot
Q92820
canonical
ensembl
ENSG00000137563
resolver
ensp
ENSP00000260118
resolver
ensp
ENSP00000504520
resolver
enst
ENST00000260118
resolver
enst
ENST00000518113
resolver
genesymbol
GGH
resolver
hgnc
HGNC:4248
resolver
uniprot
A0A7I2V5X9
resolver
uniprot_entry
A0A7I2V5X9_HUMAN
resolver
uniprot_entry
GGH_HUMAN
resolver
amino_acid_sequence
MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYGVQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQFSPIYTGNISSFQQCYIFD
uniprot
proteins
ec_number
3.4.19.9
uniprot
proteins
function
FUNCTION: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate (PubMed:11005824, PubMed:8816764). May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. {ECO:0000269|PubMed:11005824, ECO:0000269|PubMed:8816764}.
uniprot
proteins
mass_dalton
35964
uniprot
proteins
mutagenesis
MUTAGEN 134; /note="C->A: Loss of activity."; /evidence="ECO:0000269|PubMed:10527932, ECO:0000269|PubMed:11005824"; MUTAGEN 195; /note="H->N: Reduces activity 250-fold."; MUTAGEN 244; /note="H->A: Loss of activity."; /evidence="ECO:0000269|PubMed:11005824"; MUTAGEN 246; /note="E->A: Slightly reduced catalytic activity."; /evidence="ECO:0000269|PubMed:11005824
uniprot
proteins
protein_family
Peptidase C26 family
uniprot
proteins
pubmed
10527932
uniprot
proteins
pubmed
10570974
uniprot
proteins
pubmed
11005824
uniprot
proteins
pubmed
11953431
uniprot
proteins
pubmed
12643545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16945597
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8816764
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000305}. Lysosome {ECO:0000269|PubMed:12643545}. Melanosome {ECO:0000269|PubMed:12643545}. Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545}.
uniprot
proteins