Slc9a9
entrez
363115
canonical
uniprot
D4A7H1
canonical
ensembl
ENSRNOG00000008554
resolver
ensembl
ENSRNOG00055017495
resolver
ensembl
ENSRNOG00060011912
resolver
ensp
ENSRNOP00000011358
resolver
ensp
ENSRNOP00055023759
resolver
ensp
ENSRNOP00060015838
resolver
enst
ENSRNOT00055029594
resolver
enst
ENSRNOT00060020165
resolver
genesymbol
Slc9a9
resolver
genesymbol_syn
Nhe9
resolver
uniprot_entry
SL9A9_RAT
resolver
amino_acid_sequence
MAGQLRLTSGKDEDHFQHQGAVELLAFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIDSGTVYNCGKLLFSPSTLLVNITDQVYEYKYQREINQHNISPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCVVIGLIMYGFVKAMVHAGQLKSGDFHFTDCLFFGSLMSATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPKENPNAFDTAAFFQSVGNFLGIFAGSFAMGSAYAVVTALLTKFTKLREFPMLETGLFFLLSWSAFLSAEAAGLTGIVAVLFCGVTQAHYTYNNLSSDSKLRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNALFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIRNTESQPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDESLKEEPSSQQEANKVDKDMTKTESAQLFRMWYGFDHKYLKPILTHSGPPLTTTLPAWCGPVSRLLTSPQAYGEQLKEDDVECIVNQDELAMNYQEQSPTSSSPATKLALDQKSSGLTLGKENIYEGDLGLGGYELKLEQTRGQPQMD
uniprot
proteins
function
FUNCTION: Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters (By similarity). Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain (By similarity). Regulates synaptic transmission by regulating the luminal pH of axonal endosomes. Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages. Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracellular pH (By similarity). {ECO:0000250|UniProtKB:Q8BZ00, ECO:0000250|UniProtKB:Q8IVB4}.
uniprot
proteins
mass_dalton
72055
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17005858
uniprot
proteins
pubmed
21858920
uniprot
proteins
sequence_length
644
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:Q8IVB4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Early endosome membrane {ECO:0000250|UniProtKB:Q8IVB4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q8IVB4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Cell membrane {ECO:0000250|UniProtKB:Q8BZ00}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q8BZ00}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Note=Localized to the plasma membrane in inner ear hair cell bundle. {ECO:0000250|UniProtKB:Q8BZ00}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:F7B113"; TRANSMEM 46..66; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:F7B113"; TRANSMEM 127..147; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:F7B113"; TRANSMEM 165..185; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:F7B113"; TRANSMEM 204..224; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:F7B113"; TRANSMEM 236..256; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:F7B113"; TRANSMEM 278..298; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:F7B113"; TRANSMEM 310..327; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:F7B113"; TRANSMEM 334..350; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:F7B113"; TRANSMEM 365..385; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:F7B113"; TRANSMEM 387..407; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:F7B113"; TRANSMEM 430..450; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:F7B113"; TRANSMEM 466..486; /note="Helical; Name=13"; /evidence="ECO:0000250|UniProtKB:F7B113
uniprot
proteins