Q8JZQ5
uniprot
Q8JZQ5
canonical
activity_regulation
ACTIVITY REGULATION: Inhibited by amiloride and amiloride analogs. {ECO:0000250|UniProtKB:P19801}.
uniprot
proteins
amino_acid_sequence
MSLAFGWAAVILLLQTADTASAVTTPHDKARIFADLSPQEIKAVHSFLMSRKELGLESSKNLTLAKNSVFLIEMLLPKKKNVLKFLDEGRKSPVREARAIIFFGAQDHPNVTEFAVGPLPRPCYVQALSPRPGHHLSWSSRPISTAEYDLLYHMLNRAITPLHQFFLDTTGFSFLGCDDRFLTFTDVAPRGVESGQRRSWLIVQRYVEGYFLHPTGLEILVDHSSTDVQDWRVEQLWYNGKFYNSPEELAQKYAVGEVEAVVLEEVVLEDPLPGATEQPPLFSSYKPRGEFHTPVTVAGPHVVQPSGPRYKLEGNVVLYGDWSFSYRLRSSSGLQIFNVLFGGERVAYEVSVQEAVALYGGHTPAGMQTKYIDVGWGLGSVTHELAPGIDCPETATFLDAFHYYDSDGPVLYPRALCLFEMPTGVPLRRHFDSNFKGGFNFYAGLKGYVLVLRTTSTVYNYDYIWDFIFYPNGVMETKMHATGYVHATFYTPEGLRHGTRLQTHLLGNIHTHLVHYRVDLDVAGTKNSFRTLKTKLENITNPWSPSHSLVQPTLEQTQYSHEHQAAFRFGQTLPKYLLFSSPQKNRWGHRRSYRLQIHSMAEQVLPPGWQEERAVTWARYPLAVTKYRESERYSSSLYNQNDPWDPPVVFEEFLRNNENIENEDLVAWVTVGFLHIPHSEDVPNTATPGNCVGFLIRPFNFFEEDPSLASRDTVIVWPQDNGLNHVQRWIPENRDCLVSPPFSYNGTYKPV
uniprot
proteins
ec_number
1.4.3.22
uniprot
proteins
function
FUNCTION: Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Its preferred substrates in vitro are the diamines histamine and 1-methylhistamine and it could therefore play a role in allergic and immune responses. Has a broad specificity for diamines and can also act on cadaverine and putrescine, two products of amino acid catabolism. It could also act on polyamines, like spermidine and spermine though less efficiently, and regulate various biological processes. {ECO:0000250|UniProtKB:P19801}.
uniprot
proteins
mass_dalton
85424
uniprot
proteins
post_translational_modification
PTM: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. {ECO:0000250|UniProtKB:P12807}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:P19801}.
uniprot
proteins
protein_family
Copper/topaquinone oxidase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
751
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250|UniProtKB:P19801}. Cell membrane {ECO:0000250|UniProtKB:P19801}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19801}; Extracellular side {ECO:0000250|UniProtKB:P19801}.
uniprot
proteins