ATG4C
entrez
84938
canonical
uniprot
Q96DT6
canonical
ensembl
ENSG00000125703
resolver
ensp
ENSP00000322159
resolver
ensp
ENSP00000360161
resolver
ensp
ENSP00000522893
resolver
ensp
ENSP00000522896
resolver
ensp
ENSP00000522898
resolver
ensp
ENSP00000522899
resolver
ensp
ENSP00000522901
resolver
ensp
ENSP00000599207
resolver
ensp
ENSP00000615416
resolver
ensp
ENSP00000615418
resolver
ensp
ENSP00000615419
resolver
enst
ENST00000317868
resolver
enst
ENST00000371120
resolver
enst
ENST00000852834
resolver
enst
ENST00000852837
resolver
enst
ENST00000852839
resolver
enst
ENST00000852840
resolver
enst
ENST00000852842
resolver
enst
ENST00000929148
resolver
enst
ENST00000945357
resolver
enst
ENST00000945359
resolver
enst
ENST00000945360
resolver
genesymbol
ATG4C
resolver
genesymbol_syn
APG4C
resolver
genesymbol_syn
AUTL1
resolver
genesymbol_syn
AUTL3
resolver
hgnc
HGNC:16040
resolver
uniprot
A0A384MTY5
resolver
uniprot
A6NLR8
resolver
uniprot
D3DQ58
resolver
uniprot
Q96K04
resolver
uniprot_entry
A0A384MTY5_HUMAN
resolver
uniprot_entry
ATG4C_HUMAN
resolver
uniprot_sec
A6NLR8
resolver
uniprot_sec
D3DQ58
resolver
uniprot_sec
Q96K04
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethylmaleimide. {ECO:0000269|PubMed:21177865}.
uniprot
proteins
amino_acid_sequence
MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLPAESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKETIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGERTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVNGHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
function
FUNCTION: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:21177865, PubMed:29458288, PubMed:30661429). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine (PubMed:21177865). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:29458288, PubMed:33909989). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:29458288, PubMed:33909989). Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity (PubMed:29458288). In contrast to other members of the family, weakly or not involved in phagophore growth during mitophagy (PubMed:33773106). {ECO:0000250|UniProtKB:Q9Y4P1, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:29458288, ECO:0000269|PubMed:30661429, ECO:0000269|PubMed:33773106, ECO:0000269|PubMed:33909989}.
uniprot
proteins
mass_dalton
52497
uniprot
proteins
protein_family
Peptidase C54 family
uniprot
proteins
pubmed
12446702
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21177865
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29458288
uniprot
proteins
pubmed
30661429
uniprot
proteins
pubmed
30808002
uniprot
proteins
pubmed
33773106
uniprot
proteins
pubmed
33909989
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BGE6}.
uniprot
proteins