Gtf2h5
entrez
66467
canonical
uniprot
Q8K2X8
canonical
ensembl
ENSMUSG00000034345
resolver
ensp
ENSMUSP00000040355
resolver
ensp
ENSMUSP00000098515
resolver
ensp
ENSMUSP00000287314
resolver
enst
ENSMUST00000039487
resolver
enst
ENSMUST00000100955
resolver
genesymbol
Gtf2h5
resolver
genesymbol_syn
D17Wsu155e
resolver
uniprot
Q8BT75
resolver
uniprot_entry
TF2H5_MOUSE
resolver
uniprot_sec
Q8BT75
resolver
amino_acid_sequence
MVNVLKGVLIECDPAMKQFLLYLDEANALGKKFIIQDIDDTHVFVIAELVNVLQERVGELMDQNAFSLTQK
uniprot
proteins
function
FUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell. {ECO:0000250|UniProtKB:Q6ZYL4}.
uniprot
proteins
mass_dalton
8037
uniprot
proteins
protein_family
TFB5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
28888655
uniprot
proteins
sequence_length
71
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28888655}. Cytoplasm {ECO:0000269|PubMed:28888655}.
uniprot
proteins