SLC35B1
entrez
10237
canonical
uniprot
P78383
canonical
ensembl
ENSG00000121073
resolver
ensp
ENSP00000240333
resolver
ensp
ENSP00000423323
resolver
genesymbol
SLC35B1
resolver
genesymbol_syn
UGTREL1
resolver
hgnc
HGNC:20798
resolver
uniprot
B4DEC4
resolver
uniprot
J3KQV4
resolver
uniprot
Q96EW7
resolver
uniprot_entry
S35B1_HUMAN
resolver
uniprot_sec
B4DEC4
resolver
uniprot_sec
J3KQV4
resolver
uniprot_sec
Q96EW7
resolver
amino_acid_sequence
MASSSSLVPDRLRLPLCFLGVFVCYFYYGILQEKITRGKYGEGAKQETFTFALTLVFIQCVINAVFAKILIQFFDTARVDRTRSWLYAACSISYLGAMVSSNSALQFVNYPTQVLGKSCKPIPVMLLGVTLLKKKYPLAKYLCVLLIVAGVALFMYKPKKVVGIEEHTVGYGELLLLLSLTLDGLTGVSQDHMRAHYQTGSNHMMLNINLWSTLLLGMGILFTGELWEFLSFAERYPAIIYNILLFGLTSALGQSFIFMTVVYFGPLTCSIITTTRKFFTILASVILFANPISPMQWVGTVLVFLGLGLDAKFGKGAKKTSH
uniprot
proteins
function
FUNCTION: ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane (PubMed:30154480, PubMed:35041824, PubMed:40399679). Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction (PubMed:30154480, PubMed:35041824, PubMed:40399679). Regulates ER energy metabolism and protein biogenesis (PubMed:30154480). Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply (PubMed:30154480). Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER (PubMed:30154480, PubMed:35041824). Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established (PubMed:30154480, PubMed:35041824). {ECO:0000269|PubMed:30154480, ECO:0000269|PubMed:35041824, ECO:0000269|PubMed:40399679}.; FUNCTION: [Isoform 1]: ATP:ADP antiporter. {ECO:0000269|PubMed:30154480, ECO:0000269|PubMed:35041824, ECO:0000269|PubMed:40399679}.; FUNCTION: [Isoform 2]: ATP:ADP antiporter. {ECO:0000269|PubMed:30154480}.
uniprot
proteins
mass_dalton
35760
uniprot
proteins
mutagenesis
MUTAGEN 25; /note="Y->A: Decreases ADP uptake."; /evidence="ECO:0000269|PubMed:40399679"; MUTAGEN 94; /note="Y->A: Decreases ADP uptake."; /evidence="ECO:0000269|PubMed:40399679"; MUTAGEN 117; /note="K->A: Loss of ATP:ADP antiporter activity. Decreases ADP uptake."; /evidence="ECO:0000269|PubMed:35041824, ECO:0000269|PubMed:40399679"; MUTAGEN 120; /note="K->A: Loss of ATP:ADP antiporter activity. Decreases ADP uptake."; /evidence="ECO:0000269|PubMed:35041824, ECO:0000269|PubMed:40399679"; MUTAGEN 190; /note="Q->A: Decreases ADP uptake."; /evidence="ECO:0000269|PubMed:40399679"; MUTAGEN 254; /note="Q->A: Decreases ADP uptake."; /evidence="ECO:0000269|PubMed:40399679"; MUTAGEN 257; /note="I->E: Decreases ADP uptake."; /evidence="ECO:0000269|PubMed:40399679"; MUTAGEN 261; /note="V->T: Decreases ADP uptake."; /evidence="ECO:0000269|PubMed:40399679"; MUTAGEN 273; /note="T->A: Decreases ADP uptake."; /evidence="ECO:0000269|PubMed:40399679"; MUTAGEN 276; /note="R->A: Loss of ATP:ADP antiporter activity. Decreases ADP uptake."; /evidence="ECO:0000269|PubMed:35041824, ECO:0000269|PubMed:40399679"; MUTAGEN 277; /note="K->A: Loss of ATP:ADP antiporter activity. Decreases ADP uptake."; /evidence="ECO:0000269|PubMed:35041824, ECO:0000269|PubMed:40399679
uniprot
proteins
protein_family
Nucleotide-sugar transporter family
uniprot
proteins
protein_family
SLC35B subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
30154480
uniprot
proteins
pubmed
35041824
uniprot
proteins
pubmed
40399679
uniprot
proteins
pubmed
9010752
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30154480}; Multi-pass membrane protein {ECO:0000269|PubMed:40399679}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:40399679, ECO:0007744|PDB:9GRY, ECO:0007744|PDB:9GRZ, ECO:0007744|PDB:9GS3, ECO:0007744|PDB:9GS5, ECO:0007744|PDB:9GS7, ECO:0007744|PDB:9GSL, ECO:0007744|PDB:9I20"; TRANSMEM 51..71; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:40399679, ECO:0007744|PDB:9GRY, ECO:0007744|PDB:9GRZ, ECO:0007744|PDB:9GS3, ECO:0007744|PDB:9GS5, ECO:0007744|PDB:9GS7, ECO:0007744|PDB:9GSL, ECO:0007744|PDB:9I20"; TRANSMEM 85..105; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:40399679, ECO:0007744|PDB:9GRY, ECO:0007744|PDB:9GRZ, ECO:0007744|PDB:9GS3, ECO:0007744|PDB:9GS5, ECO:0007744|PDB:9GS7, ECO:0007744|PDB:9GSL, ECO:0007744|PDB:9I20"; TRANSMEM 109..131; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:40399679, ECO:0007744|PDB:9GRY, ECO:0007744|PDB:9GRZ, ECO:0007744|PDB:9GS3, ECO:0007744|PDB:9GS5, ECO:0007744|PDB:9GS7, ECO:0007744|PDB:9GSL, ECO:0007744|PDB:9I20"; TRANSMEM 138..156; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:40399679, ECO:0007744|PDB:9GRY, ECO:0007744|PDB:9GRZ, ECO:0007744|PDB:9GS3, ECO:0007744|PDB:9GS5, ECO:0007744|PDB:9GS7, ECO:0007744|PDB:9GSL, ECO:0007744|PDB:9I20"; TRANSMEM 174..189; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:40399679, ECO:0007744|PDB:9GRY, ECO:0007744|PDB:9GRZ, ECO:0007744|PDB:9GS3, ECO:0007744|PDB:9GS5, ECO:0007744|PDB:9GS7, ECO:0007744|PDB:9GSL, ECO:0007744|PDB:9I20"; TRANSMEM 205..222; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:40399679, ECO:0007744|PDB:9GRY, ECO:0007744|PDB:9GRZ, ECO:0007744|PDB:9GS3, ECO:0007744|PDB:9GS5, ECO:0007744|PDB:9GS7, ECO:0007744|PDB:9GSL, ECO:0007744|PDB:9I20"; TRANSMEM 239..259; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:40399679, ECO:0007744|PDB:9GRY, ECO:0007744|PDB:9GRZ, ECO:0007744|PDB:9GS3, ECO:0007744|PDB:9GS5, ECO:0007744|PDB:9GS7, ECO:0007744|PDB:9GSL, ECO:0007744|PDB:9I20"; TRANSMEM 267..287; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:40399679, ECO:0007744|PDB:9GRY, ECO:0007744|PDB:9GRZ, ECO:0007744|PDB:9GS3, ECO:0007744|PDB:9GS5, ECO:0007744|PDB:9GS7, ECO:0007744|PDB:9GSL, ECO:0007744|PDB:9I20"; TRANSMEM 294..313; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:40399679, ECO:0007744|PDB:9GRY, ECO:0007744|PDB:9GRZ, ECO:0007744|PDB:9GS3, ECO:0007744|PDB:9GS5, ECO:0007744|PDB:9GS7, ECO:0007744|PDB:9GSL, ECO:0007744|PDB:9I20
uniprot
proteins