Klf10
entrez
21847
canonical
uniprot
O89091
canonical
ensembl
ENSMUSG00000037465
resolver
ensp
ENSMUSP00000073690
resolver
ensp
ENSMUSP00000154265
resolver
enst
ENSMUST00000074043
resolver
enst
ENSMUST00000227920
resolver
genesymbol
Klf10
resolver
genesymbol_syn
Gdnfif
resolver
genesymbol_syn
Tieg
resolver
genesymbol_syn
Tieg1
resolver
uniprot
A0A2I3BQQ2
resolver
uniprot
Q8C900
resolver
uniprot_entry
A0A2I3BQQ2_MOUSE
resolver
uniprot_entry
KLF10_MOUSE
resolver
uniprot_entry
Q8C900_MOUSE
resolver
amino_acid_sequence
MLNFGASLQQASEGKMELISEKPREGMHPWDKAEQSDFEAVEALMSMSCDWKSHFKKYLENRPVTPVSDTSEDDSLLPGTPDLQTVPAFCLTPPYSPSDFEPSQGSNLTASAPSTGHFKSFSDAAKPPGATPFKEEEKNPLAAPPLPKAQATSVIRHTADAQLCNHQSCPVKAASILNYQDNSFRRRTHGNVEATRKNIPCAAVSPNRSKPEPSTVSDGDEKAGAALYDFAVPSSETVICRSQPAPSSPVQKSVLVSSPTVSTGGVPPLPVICQMVPLPANNSLVSTVVPSTPPSQPPAVCSPVLFMGTQVPEGTVVFVVPQPVVQSPRPPVVSPSGTRLSPIAPAPGFSPSAARVTPQIDSSRVRSHICSHPGCGKTYFKSSHLKAHVRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDRRFMRSDHLTKHARRHLSAKKLPNWQMEVSKLNDIALPPTPASAQ
uniprot
proteins
function
FUNCTION: Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. {ECO:0000250|UniProtKB:Q13118, ECO:0000269|PubMed:20070857, ECO:0000269|PubMed:20385766}.
uniprot
proteins
mass_dalton
51756
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. {ECO:0000250|UniProtKB:Q13118}.
uniprot
proteins
protein_family
Sp1 C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20070857
uniprot
proteins
pubmed
20385766
uniprot
proteins
pubmed
9348334
uniprot
proteins
pubmed
9745041
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20070857}.
uniprot
proteins