Q62871
uniprot
Q62871
canonical
amino_acid_sequence
MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAAVSVQEESDLEKKRREAEALLQSMGLTTDSPIVFSEHWVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRTLHWDTDPSALQLHSDSDLGRGPIKLGMAKITQVDFPPREIVTYTKETQTPVTAQPKEDEEEEDDVAAPKPPVEPEEEKILKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEEAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNKPLYSFEDNSDYVYDVIGSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINASRADAEEEAATRIPA
uniprot
proteins
function
FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:11340075). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:11340075). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (PubMed:11340075). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (PubMed:11340075). {ECO:0000269|PubMed:11340075}.
uniprot
proteins
mass_dalton
71178
uniprot
proteins
mutagenesis
MUTAGEN 90; /note="S->A: No effect on interaction with DCTN1 (mimicks dephosphorylated form)."; /evidence="ECO:0000269|PubMed:11340075"; MUTAGEN 90; /note="S->D: Impairs interaction with DCTN1 (mimicks phosphorylated form)."; /evidence="ECO:0000269|PubMed:11340075
uniprot
proteins
post_translational_modification
PTM: The phosphorylation status of Ser-90 appears to be involved in dynactin-dependent target binding. {ECO:0000269|PubMed:11340075}.; PTM: Pyrophosphorylation by 5-diphosphoinositol pentakisphosphate (5-IP7) promotes interaction with DCTN1. Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue. {ECO:0000250|UniProtKB:O88487}.
uniprot
proteins
protein_family
Dynein intermediate chain family
uniprot
proteins
pubmed
10893223
uniprot
proteins
pubmed
11340075
uniprot
proteins
pubmed
17279546
uniprot
proteins
pubmed
17965411
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
27502274
uniprot
proteins
pubmed
8522607
uniprot
proteins
pubmed
8688562
uniprot
proteins
pubmed
9790665
uniprot
proteins
sequence_length
638
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11340075}. Cytoplasm {ECO:0000250|UniProtKB:O88487}. Note=Detected in the cytoplasm of pachytene spermatocytes. Localizes to the manchette in elongating spermatids. {ECO:0000250|UniProtKB:O88487}.
uniprot
proteins