Clec4e
entrez
56619
canonical
uniprot
Q9R0Q8
canonical
ensembl
ENSMUSG00000030142
resolver
ensp
ENSMUSP00000032239
resolver
enst
ENSMUST00000032239
resolver
genesymbol
Clec4e
resolver
genesymbol_syn
Clecsf9
resolver
genesymbol_syn
Mincle
resolver
uniprot
Q4FK29
resolver
uniprot_entry
CLC4E_MOUSE
resolver
uniprot_entry
Q4FK29_MOUSE
resolver
amino_acid_sequence
MNSTKSPASHHTERGCFKNSQVLSWTIAGASILFLSGCFITRCVVTYRSSQISGQNLQPHRNIKELSCYSEASGSVKNCCPLNWKHYQSSCYFFSTTTLTWSSSLKNCSDMGAHLVVIDTQEEQEFLFRTKPKRKEFYIGLTDQVVEGQWQWVDDTPFTESLSFWDAGEPNNIVLVEDCATIRDSSNSRKNWNDIPCFYSMPWICEMPEISPLD
uniprot
proteins
function
FUNCTION: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:18490740, PubMed:18509109, PubMed:18776906, PubMed:19171887, PubMed:20008526, PubMed:23602766). The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions (PubMed:20008526, PubMed:23602766). Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells (PubMed:18776906, PubMed:23602766). Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 (Th1) and T-helper 17 (Th17) cell subtypes (PubMed:23602766). Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation (PubMed:19171887). Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue (PubMed:18776906). {ECO:0000269|PubMed:18490740, ECO:0000269|PubMed:18509109, ECO:0000269|PubMed:18776906, ECO:0000269|PubMed:19171887, ECO:0000269|PubMed:20008526, ECO:0000269|PubMed:23602766}.
uniprot
proteins
mass_dalton
24431
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="R->I: Abolishes the association with FCER1G."; /evidence="ECO:0000269|PubMed:18776906"; MUTAGEN 169; /note="E->Q: Abrogates Malassezia recognition; when associated with D-171."; /evidence="ECO:0000269|PubMed:19171887"; MUTAGEN 171; /note="N->D: Abrogates Malassezia recognition; when associated with Q-169."; /evidence="ECO:0000269|PubMed:19171887
uniprot
proteins
pubmed
10528209
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18490740
uniprot
proteins
pubmed
18509109
uniprot
proteins
pubmed
18776906
uniprot
proteins
pubmed
19171887
uniprot
proteins
pubmed
20008526
uniprot
proteins
pubmed
23602766
uniprot
proteins
sequence_length
214
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18490740, ECO:0000305|PubMed:10528209, ECO:0000305|PubMed:23602766}; Single-pass type II membrane protein {ECO:0000305|PubMed:10528209}. Cell projection, phagocytic cup {ECO:0000269|PubMed:18490740}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..45; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins