Aqp6
entrez
29170
canonical
uniprot
Q9WTY0
canonical
ensembl
ENSRNOG00000063448
resolver
ensembl
ENSRNOG00055029603
resolver
ensembl
ENSRNOG00060006532
resolver
ensembl
ENSRNOG00065022399
resolver
ensp
ENSRNOP00000092300
resolver
ensp
ENSRNOP00055042221
resolver
ensp
ENSRNOP00060007925
resolver
ensp
ENSRNOP00065030924
resolver
enst
ENSRNOT00000098480
resolver
enst
ENSRNOT00055051252
resolver
enst
ENSRNOT00060010694
resolver
enst
ENSRNOT00065038198
resolver
genesymbol
Aqp6
resolver
uniprot_entry
AQP6_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by mercury and pH-gated, anion permeability is observed at pH 5.5 and increases markedly at pH 4.0. Selectivity for chloride increases at low pH. The water channel activity is stimulated by mercury by opposition to other aquaporins. {ECO:0000269|PubMed:10647010}.
uniprot
proteins
amino_acid_sequence
MEPGLCNRAYLLVGGLWTAISKALFAEFLATGLYVFFGVGSVLPWPVALPSVLQVAITFNLATATAVQISWKTSGAHANPAVTLAYLVGSHISLPRAVAYIAAQLAGATVGAALLYGVTPGGVRETLGVNVVHNSTSTGQAVAVELVLTLQLVLCVFASMDSRQTLGSPAAMIGTSVALGHLIGIYFTGCSMNPARSFGPAVIVGKFAVHWIFWVGPLTGAVLASLIYNFILFPDTKTVAQRLAILVGTTKVEKVVDLEPQKKESQTNSEDTEVSV
uniprot
proteins
function
FUNCTION: Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (PubMed:10647010, PubMed:12034750, PubMed:12177001). Unlike classical aquaporins, AQP6 is an intracellular channel with selective anion permeability, particularly for nitrate, and exhibits very low water permeability (PubMed:10647010, PubMed:12034750, PubMed:23485707). It may also facilitate the transport of gases, such as CO2 and NH4(+), as demonstrated in vitro (PubMed:23485707). {ECO:0000269|PubMed:10647010, ECO:0000269|PubMed:12034750, ECO:0000269|PubMed:12177001, ECO:0000269|PubMed:23485707}.
uniprot
proteins
mass_dalton
28860
uniprot
proteins
mutagenesis
MUTAGEN 60; /note="N->G: Increased water channel activity."; /evidence="ECO:0000269|PubMed:23485707"; MUTAGEN 63; /note="T->I: Reduced selectivity for nitrate with respect to chloride."; /evidence="ECO:0000269|PubMed:12177001"; MUTAGEN 72; /note="K->E: Loss of chloride ion selectivity with respect to sodium."; /evidence="ECO:0000269|PubMed:10647010"; MUTAGEN 72; /note="K->H: No effect on chloride ion selectivity with respect to sodium."; /evidence="ECO:0000269|PubMed:10647010
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10318966}.
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
10318966
uniprot
proteins
pubmed
10647010
uniprot
proteins
pubmed
12034750
uniprot
proteins
pubmed
12177001
uniprot
proteins
pubmed
23485707
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10318966, ECO:0000269|PubMed:10647010}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 52..70; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 97..118; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 166..185; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181
uniprot
proteins