Tecr
entrez
191576
canonical
uniprot
Q64232
canonical
ensembl
ENSRNOG00000021808
resolver
ensp
ENSRNOP00000080279
resolver
ensp
ENSRNOP00000083676
resolver
genesymbol
Tecr
resolver
genesymbol_syn
Gpsn2
resolver
uniprot
B3SVE9
resolver
uniprot_entry
B3SVE9_RAT
resolver
uniprot_entry
TECR_RAT
resolver
amino_acid_sequence
MKHYEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGVQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL
uniprot
proteins
ec_number
1.3.1.93
uniprot
proteins
function
FUNCTION: Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (By similarity). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (By similarity). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (By similarity). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (By similarity). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (By similarity). {ECO:0000250|UniProtKB:Q9NZ01}.
uniprot
proteins
mass_dalton
36123
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000250|UniProtKB:Q9NZ01}.; PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000250|UniProtKB:Q9NZ01}.
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:1404491}.
uniprot
proteins
protein_family
Steroid 5-alpha reductase family
uniprot
proteins
pubmed
1404491
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NZ01}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 87..106; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NZ01"; TRANSMEM 125..147; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NZ01"; TRANSMEM 159..180; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NZ01"; TRANSMEM 190..216; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NZ01"; TRANSMEM 246..262; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NZ01"; TRANSMEM 265..292; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NZ01
uniprot
proteins