ABCB8
entrez
11194
canonical
uniprot
Q9NUT2
canonical
ensembl
ENSG00000197150
resolver
ensp
ENSP00000297504
resolver
ensp
ENSP00000351717
resolver
ensp
ENSP00000418271
resolver
ensp
ENSP00000438776
resolver
genesymbol
ABCB8
resolver
genesymbol_syn
MABC1
resolver
genesymbol_syn
MITOSUR
resolver
hgnc
HGNC:49
resolver
uniprot
A5D8W3
resolver
uniprot
B2RBL8
resolver
uniprot
B3KND2
resolver
uniprot
B4DG02
resolver
uniprot
G3XAP3
resolver
uniprot
O95787
resolver
uniprot
Q53GM0
resolver
uniprot_entry
MITOS_HUMAN
resolver
uniprot_sec
A5D8W3
resolver
uniprot_sec
B2RBL8
resolver
uniprot_sec
B3KND2
resolver
uniprot_sec
B4DG02
resolver
uniprot_sec
G3XAP3
resolver
uniprot_sec
O95787
resolver
uniprot_sec
Q53GM0
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity inhibited by ATP via ABCB8/MITOSUR subunit. {ECO:0000269|PubMed:31435016}.
uniprot
proteins
amino_acid_sequence
MLVHLFRVGIRGGPFPGRLLPPLRFQTFSAVRNTWRNGKTGQLHKAEGEYSDGYRSSSLLRAVAHLRSQLWAHLPRAPLAPRWSPSAWCWVGGALLGPMVLSKHPHLCLVALCEAEEAPPASSTPHVVGSRFNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQALDAPRTAAPPPKKPEGPRSHQHKS
uniprot
proteins
function
FUNCTION: ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)) (PubMed:31435016). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane (PubMed:31435016). An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix (PubMed:31435016). Plays a role in mitochondrial iron transport (PubMed:30623799). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity). {ECO:0000250|UniProtKB:Q9CXJ4, ECO:0000269|PubMed:30623799, ECO:0000269|PubMed:31435016}.
uniprot
proteins
mass_dalton
79989
uniprot
proteins
mutagenesis
MUTAGEN 512..513; /note="GK->AR: Renders the protein unstable."; /evidence="ECO:0000269|PubMed:9878413"; MUTAGEN 513; /note="K->A: Abolish binding to ATP."; /evidence="ECO:0000269|PubMed:31435016
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCB family
uniprot
proteins
protein_family
Multidrug resistance exporter (TC 3.A.1.201) subfamily
uniprot
proteins
pubmed
11829140
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16259955
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
21046154
uniprot
proteins
pubmed
25063848
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30623799
uniprot
proteins
pubmed
31435016
uniprot
proteins
pubmed
9878413
uniprot
proteins
sequence_length
735
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:16259955, ECO:0000269|PubMed:31435016}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
uniprot
proteins
transmembrane_region
TRANSMEM 145..165; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 296..316; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins