Twsg1
entrez
65960
canonical
uniprot
Q9EP52
canonical
ensembl
ENSMUSG00000024098
resolver
ensp
ENSMUSP00000024906
resolver
ensp
ENSMUSP00000156695
resolver
enst
ENSMUST00000024906
resolver
enst
ENSMUST00000233580
resolver
genesymbol
Twsg1
resolver
genesymbol_syn
Tsg
resolver
uniprot
Q8CCB1
resolver
uniprot
Q8CEM6
resolver
uniprot
Q99K77
resolver
uniprot
Q9ERN7
resolver
uniprot_entry
TWSG1_MOUSE
resolver
uniprot_sec
Q8CCB1
resolver
uniprot_sec
Q8CEM6
resolver
uniprot_sec
Q99K77
resolver
uniprot_sec
Q9ERN7
resolver
amino_acid_sequence
MKSHYIVLALASLTFLLCLPVSQSCNKALCASDVSKCLIQELCQCRPGEGNCPCCKECMLCLGALWDECCDCVGMCNPRNYSDTPPTSKSTVEELHEPIPSLFRALTEGDTQLNWNIVSFPVAEELSHHENLVSFLETVNQLHHQNVSVPSNNVHAPFPSDKERMCTVVYFDDCMSIHQCKISCESMGASKYRWFHNACCECIGPECIDYGSKTVKCMNCMF
uniprot
proteins
function
FUNCTION: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development. {ECO:0000269|PubMed:11260715, ECO:0000269|PubMed:12119341, ECO:0000269|PubMed:15843411, ECO:0000269|PubMed:16905550}.
uniprot
proteins
mass_dalton
24801
uniprot
proteins
protein_family
Twisted gastrulation protein family
uniprot
proteins
pubmed
11260715
uniprot
proteins
pubmed
11420619
uniprot
proteins
pubmed
12119341
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15843411
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16905550
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins