STRA8
entrez
346673
canonical
uniprot
Q7Z7C7
canonical
ensembl
ENSG00000146857
resolver
ensp
ENSP00000275764
resolver
ensp
ENSP00000499386
resolver
ensp
ENSP00000499721
resolver
enst
ENST00000275764
resolver
enst
ENST00000662584
resolver
enst
ENST00000667288
resolver
genesymbol
STRA8
resolver
hgnc
HGNC:30653
resolver
uniprot
A0A590UJF1
resolver
uniprot
A0A590UK75
resolver
uniprot_entry
A0A590UJF1_HUMAN
resolver
uniprot_entry
A0A590UK75_HUMAN
resolver
uniprot_entry
STRA8_HUMAN
resolver
amino_acid_sequence
MGKIDVDKILFFNQEIRLWQLIMATPEENSNPHDRATPQLPAQLQELEHRVARRRLSQARHRATLAALFNNLRKTVYSQSDLIASKWQVLNKAKSHIPELEQTLDNLLKLKASFNLEDGHASSLEEVKKEYASMYSGNDSFPQNGSSPWYLNFYKQTMDLLTGSGIITPQEAALPIVSAAISHLWQNLSEERKASLRQAWAQKHRGPATLAEACREPACAEGSVKDSGVDSQGASCSLVSTPEEILFEDAFDVASFLDKSEVPSTSSSSSVLASCNPENPEEKFQLYMQIINFFKGLSCANTQVKQEASFPVDEEMIMLQCTETFDDEDL
uniprot
proteins
function
FUNCTION: Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis. {ECO:0000250|UniProtKB:P70278}.
uniprot
proteins
mass_dalton
36908
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:P70278}.
uniprot
proteins
pubmed
12489526
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
26742488
uniprot
proteins
pubmed
28718531
uniprot
proteins
sequence_length
330
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P70278}. Nucleus {ECO:0000250|UniProtKB:P70278}. Note=Shuttles between nucleus and cytoplasm. Nuclear export is XPO1-dependent. {ECO:0000250|UniProtKB:P70278}.
uniprot
proteins