TAF1B
entrez
9014
canonical
uniprot
Q53T94
canonical
ensembl
ENSG00000115750
resolver
ensp
ENSP00000263663
resolver
genesymbol
TAF1B
resolver
hgnc
HGNC:11533
resolver
uniprot
B4DI42
resolver
uniprot
F8WD72
resolver
uniprot
Q15574
resolver
uniprot
Q8WVC3
resolver
uniprot_entry
TAF1B_HUMAN
resolver
uniprot_sec
B4DI42
resolver
uniprot_sec
F8WD72
resolver
uniprot_sec
Q15574
resolver
uniprot_sec
Q8WVC3
resolver
amino_acid_sequence
MDLEEAEEFKERCTQCAAVSWGLTDEGKYYCTSCHNVTERYQEVTNTDLIPNTQIKALNRGLKKKNNTEKGWDWYVCEGFQYILYQQAEALKNLGVGPELKNDVLHNFWKRYLQKSKQAYCKNPVYTTGRKPTVLEDNLSHSDWASEPELLSDVSCPPFLESGAESQSDIHTRKPFPVSKASQSETSVCSGSLDGVEYSQRKEKGIVKMTMPQTLAFCYLSLLWQREAITLSDLLRFVEEDHIPYINAFQHFPEQMKLYGRDRGIFGIESWPDYEDIYKKTVEVGTFLDLPRFPDITEDCYLHPNILCMKYLMEVNLPDEMHSLTCHVVKMTGMGEVDFLTFDPIAKMAKTVKYDVQAVAIIVVVLKLLFLLDDSFEWSLSNLAEKHNEKNKKDKPWFDFRKWYQIMKKAFDEKKQKWEEARAKYLWKSEKPLYYSFVDKPVAYKKREMVVNLQKQFSTLVESTATAGKKSPSSFQFNWTEEDTDRTCFHGHSLQGVLKEKGQSLLTKNSLYWLSTQKFCRCYCTHVTTYEESNYSLSYQFILNLFSFLLRIKTSLLHEEVSLVEKKLFEKKYSVKRKKSRSKKVRRH
uniprot
proteins
function
FUNCTION: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:21921198, ECO:0000269|PubMed:21921199, ECO:0000269|PubMed:7491500, ECO:0000269|PubMed:7801123, ECO:0000269|PubMed:7801130}.
uniprot
proteins
mass_dalton
68832
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="C->A: Abolishes Pol I transcription but not recruitment of SL1/TIF-IB complex to rDNA promoters."; /evidence="ECO:0000269|PubMed:21921199"; MUTAGEN 31; /note="C->A: Abolishes Pol I transcription but not recruitment of SL1/TIF-IB complex to rDNA promoters."; /evidence="ECO:0000269|PubMed:21921199"; MUTAGEN 34; /note="C->A: Abolishes Pol I transcription but not recruitment of SL1/TIF-IB complex to rDNA promoters."; /evidence="ECO:0000269|PubMed:21921199
uniprot
proteins
protein_family
RRN7/TAF1B family
uniprot
proteins
pubmed
10894955
uniprot
proteins
pubmed
11250903
uniprot
proteins
pubmed
11283244
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15970593
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21921198
uniprot
proteins
pubmed
21921199
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
7491500
uniprot
proteins
pubmed
7801123
uniprot
proteins
pubmed
7801130
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000305|PubMed:11250903, ECO:0000305|PubMed:11283244}.
uniprot
proteins