Cox15
entrez
226139
canonical
uniprot
Q8BJ03
canonical
ensembl
ENSMUSG00000040018
resolver
ensp
ENSMUSP00000041820
resolver
genesymbol
Cox15
resolver
uniprot
Q3URB2
resolver
uniprot
Q8VDN0
resolver
uniprot
Q921K5
resolver
uniprot_entry
COX15_MOUSE
resolver
uniprot_sec
Q3URB2
resolver
uniprot_sec
Q8VDN0
resolver
uniprot_sec
Q921K5
resolver
amino_acid_sequence
MQRLLLPSLRALTGSRNVGLLVPRVASRTQCGSSCGSQRPLRPGQYSTITEVALQSGKGTVSLPSRAAERAVGRWLLVCSGTVAGAVILGGVTRLTESGLSMVDWHLIKEMKPPTSQEEWEAEFQKYQQFPEFKILNHDMTLAEFKFIWYMEYSHRMWGRAVGLAYILPAAYFWRKGWLNRGMKGRVLALCGLVCFQGLLGWYMVKSGLEEKPESYDIPRVSQYRLAAHLGSALVLYCASLWTSLSLLLPQHKLPETRQLLWLRRFAGGTAGLVFLTALSGAFVAGLDAGLVYNSFPKMGESWIPEDLLTFSPVLKNVFENPTMVQFDHRLLGVTSVTAITVLYFLSRRIPLPRRTKMAAVTLLALAYAQVALGISTLLMYVPTPLAATHQSGSLALLSGALWLMNELRRVPK
uniprot
proteins
ec_number
1.17.99.9
uniprot
proteins
function
FUNCTION: Catalyzes the second reaction in the biosynthesis of heme A, a prosthetic group of mitochondrial cytochrome c oxidase (CcO). Heme A is synthesized from heme B by two sequential enzymatic reactions catalyzed by heme O synthase (HOS) and heme A synthase (HAS). HAS catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8, in a reaction that involves matrix ferredoxin and ferredoxin reductase. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A. {ECO:0000250|UniProtKB:P40086}.
uniprot
proteins
mass_dalton
45853
uniprot
proteins
pathway_participation
PATHWAY: Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1. {ECO:0000250|UniProtKB:P40086}.
uniprot
proteins
protein_family
COX15/CtaA family
uniprot
proteins
protein_family
Type 2 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
413
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P40086}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 157..174; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 187..207; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 230..250; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 272..292; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 330..347; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 360..380; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 385..405; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins