KCNJ4
entrez
3761
canonical
uniprot
P48050
canonical
ensembl
ENSG00000168135
resolver
ensp
ENSP00000306497
resolver
ensp
ENSP00000610622
resolver
ensp
ENSP00000617162
resolver
enst
ENST00000303592
resolver
enst
ENST00000940563
resolver
enst
ENST00000947103
resolver
genesymbol
KCNJ4
resolver
genesymbol_syn
IRK3
resolver
hgnc
HGNC:6265
resolver
uniprot
Q14D44
resolver
uniprot
Q58F07
resolver
uniprot_entry
KCNJ4_HUMAN
resolver
uniprot_entry
Q58F07_HUMAN
resolver
uniprot_sec
Q14D44
resolver
amino_acid_sequence
MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. {ECO:0000269|PubMed:7576658, ECO:0000269|PubMed:8016146, ECO:0000269|PubMed:8034048, ECO:0000269|PubMed:8051145}.
uniprot
proteins
mass_dalton
49500
uniprot
proteins
mutagenesis
MUTAGEN 117; /note="H->E: Abolishes inwardly rectifying potassium currents and pH-sensitivity."; /evidence="ECO:0000269|PubMed:7576658
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ4 subfamily
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12032359
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19635485
uniprot
proteins
pubmed
7576658
uniprot
proteins
pubmed
8016146
uniprot
proteins
pubmed
8034048
uniprot
proteins
pubmed
8051145
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P52189}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P52189}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P52189}. Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 family members and KCNJ4 internalization. {ECO:0000250|UniProtKB:P52189}.
uniprot
proteins
transmembrane_region
TRANSMEM 56..80; /note="Helical; Name=M1"; /evidence="ECO:0000250"; TRANSMEM 149..170; /note="Helical; Name=M2"; /evidence="ECO:0000250
uniprot
proteins