Parp16
entrez
315760
canonical
uniprot
Q5U2Q4
canonical
genesymbol
Parp16
resolver
genesymbol_syn
Artd15
resolver
uniprot_entry
PAR16_RAT
resolver
activity_regulation
ACTIVITY REGULATION: In absence of activation signal, PARP16 is autoinhibited by the PARP alpha-helical domain (also named HD region), which prevents effective NAD(+)-binding. Activity is highly stimulated by signals, which unfold the PARP alpha-helical domain, relieving autoinhibition. {ECO:0000250|UniProtKB:Q9UGN5}.
uniprot
proteins
amino_acid_sequence
MQLSNRAAARESVSRDVLAADLRCSLFASALQSYKRDSVLRPFPASYARHDCKDFEALLADTGRLPNLKELLQSSRDTDKQTWDLVSWILSSKILTIHSAEKAEFEKIQQLTGAPHTPVPIPDFLFEIEYFDPANARFYETKGGRDLIYAFHGSRLENFHSIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGRGWQHSLLGQTLSCVAVCEVIDHPDVKCQTKKKDSKEIDRSRARIKHSEGGDVPPKYFVVTNNQLLRVKYLLVYSQKQPKRASSQLSWLCSHWFMVAMSLYLLLLLIVSVTNSSAFQHFWNRLKR
uniprot
proteins
ec_number
2.4.2.-
uniprot
proteins
function
FUNCTION: Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes. Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading. Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2. Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases. {ECO:0000250|UniProtKB:Q8N5Y8}.
uniprot
proteins
mass_dalton
36712
uniprot
proteins
post_translational_modification
PTM: Auto-mono-ADP-ribosylated. {ECO:0000250|UniProtKB:Q8N5Y8}.
uniprot
proteins
protein_family
ARTD/PARP family
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8N5Y8}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8N5Y8}.
uniprot
proteins
transmembrane_region
TRANSMEM 285..305; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins