Hlf
entrez
217082
canonical
uniprot
Q8BW74
canonical
ensembl
ENSMUSG00000003949
resolver
ensp
ENSMUSP00000004051
resolver
ensp
ENSMUSP00000323240
resolver
enst
ENSMUST00000004051
resolver
genesymbol
Hlf
resolver
uniprot
Q6PF83
resolver
uniprot_entry
HLF_MOUSE
resolver
uniprot_sec
Q6PF83
resolver
amino_acid_sequence
MEKMSRQLPLNPTFIPPPYGVLRSLLENPLKLPLHPEDAFSKEKDKGKKLDDESSSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSTAPSVMDLSSRATAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL
uniprot
proteins
function
FUNCTION: Transcription factor which selectively binds with high affinity to the consensus sequence 5'-GTTACGTAAT-3' and to closely related sites (By similarity). Has transcriptional activator activity (By similarity). Also has transcriptional repressor activity (PubMed:41379973). Binds to multiple sites in the promoter regions of coagulation factors F8 and F9 and activates transcription; transactivation activity is enhanced by formation of a heterodimer with DBP (By similarity). Binds to the promoter region of IRF2 and activates transcription (PubMed:29262330). Maintains quiescence of hematopoietic stem cells under steady-state conditions and protects the stem cell pool from toxic insults (PubMed:29262330). Regulates the tissue residency and proinflammatory function of CD4+ tissue-resident memory T (TRM) cells (PubMed:41379973). Down-regulates the expression of genes involved in promoting tissue egress of CD4+ TRM cells including S1PR1, KLF2 and TCF7 while up-regulating expression of tissue retention molecules such as CD69 (PubMed:41379973). Also up-regulates BHLHE40 expression, promoting proinflammatory cytokine production (PubMed:41379973). {ECO:0000250|UniProtKB:Q16534, ECO:0000269|PubMed:29262330, ECO:0000269|PubMed:41379973}.
uniprot
proteins
mass_dalton
33149
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
PAR subfamily
uniprot
proteins
pubmed
15175240
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
29262330
uniprot
proteins
pubmed
41379973
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q16534}.
uniprot
proteins