Anapc7
entrez
56317
canonical
uniprot
Q9WVM3
canonical
ensembl
ENSMUSG00000029466
resolver
ensp
ENSMUSP00000031422
resolver
ensp
ENSMUSP00000113928
resolver
enst
ENSMUST00000031422
resolver
enst
ENSMUST00000122010
resolver
genesymbol
Anapc7
resolver
genesymbol_syn
Apc7
resolver
uniprot
Q3UBM7
resolver
uniprot
Q8BSR2
resolver
uniprot
Q91W13
resolver
uniprot_entry
APC7_MOUSE
resolver
uniprot_sec
Q3UBM7
resolver
uniprot_sec
Q8BSR2
resolver
uniprot_sec
Q91W13
resolver
amino_acid_sequence
MSVIDHVRDMAAAGLHSNVRLLSSLLLTMSNNNPELFSPSQKYQLLVYHADSLFHDKEYRNAVSKYAMALQQKKALSKTSKVRPSTGNSASTPQSQCLPSEIEVKYKMAECYTMLKLDKDAIAVLDGIPSRQRTPKINMMLANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNSRAINTICSLEKKSLLRDNVDLLGSLADLYFRAGDSKNSVLKFEQAQMLDPYLIRGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALAQRPDYVKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). Has an enzyme-substrate adapter activity mediating the processive ubiquitination of specific substrates (PubMed:34942119). Involved in brain development through the specific ubiquitination and clearance of MKI67 from constitutive heterochromatin after neuronal progenitors exit mitosis (PubMed:34942119). {ECO:0000250|UniProtKB:Q9UJX3, ECO:0000269|PubMed:34942119}.
uniprot
proteins
mass_dalton
63021
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:34942119}.
uniprot
proteins
protein_family
APC7 family
uniprot
proteins
pubmed
10515598
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
34942119
uniprot
proteins
sequence_length
565
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9UJX3}. Nucleus {ECO:0000250|UniProtKB:Q9UJX3}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9UJX3}. Note=Localizes to spindle during metaphase and to cytoplasmic microtubules during interphase. {ECO:0000250|UniProtKB:Q9UJX3}.
uniprot
proteins