Catsper4
entrez
329954
canonical
uniprot
Q8BVN3
canonical
ensembl
ENSMUSG00000048003
resolver
ensp
ENSMUSP00000051694
resolver
ensp
ENSMUSP00000131094
resolver
ensp
ENSMUSP00000351696
resolver
enst
ENSMUST00000055892
resolver
enst
ENSMUST00000169381
resolver
genesymbol
Catsper4
resolver
uniprot
A2A9K6
resolver
uniprot
B3VNK5
resolver
uniprot
F7AE71
resolver
uniprot_entry
B3VNK5_MOUSE
resolver
uniprot_entry
CTSR4_MOUSE
resolver
uniprot_entry
F7AE71_MOUSE
resolver
uniprot_sec
A2A9K6
resolver
activity_regulation
ACTIVITY REGULATION: In contrast to the human ortholog, not activated by progesterone (PubMed:21412339). Activated by intracellular alkalinization (By similarity). {ECO:0000250|UniProtKB:Q7RTX7, ECO:0000269|PubMed:21412339}.
uniprot
proteins
amino_acid_sequence
MSEKHKWWQQVENIDITHLGPKRKAYELLGRHEEQVLINRRDVMEKKDAWDVQEFITQMYIKQLLRHPAFQLLLAFLLLSNAITIALRTNSYLGQKHYELFSTIDDIVLTILICEVLLGWLNGFWIFWKDGWNILNFAIVFILFMGFFIKQLDMVAITYPLRVLRLVHVCMAVEPLARIIKVILQSMPDLANVMALILFFMLVFSVFGVTLFGAFVPKHFQNMGVALYTLFICITQDGWLDIYTDFQMDEREYAMEVGGAIYFAVFITLGAFIGLNLFVVVVTTNLEQMMKTGEEEGHLNIKFTETEEDEDWTDELPLVHCTEARKDTSTVPKEPLVGGPLSNLTEKTCDNFCLVLEAIQENLMEYKEIREELNMIVEEVSSIRFNQEQQNVILHKYTSKSATFLSEPPEGANKQDLITALVSREKVSDSNINMVNKHKFSH
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. {ECO:0000269|PubMed:17227845, ECO:0000269|PubMed:17344468}.
uniprot
proteins
mass_dalton
51130
uniprot
proteins
protein_family
Cation channel sperm-associated (TC 1.A.1.19) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16107607
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17227845
uniprot
proteins
pubmed
17344468
uniprot
proteins
pubmed
17347248
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21224844
uniprot
proteins
pubmed
21412339
uniprot
proteins
pubmed
34225353
uniprot
proteins
sequence_length
442
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:16107607, ECO:0000269|PubMed:17227845}; Multi-pass membrane protein {ECO:0000269|PubMed:34225353}. Note=Specifically located in the principal piece of the sperm tail. {ECO:0000269|PubMed:17227845, ECO:0000269|PubMed:34225353}.
uniprot
proteins
transmembrane_region
TRANSMEM 67..88; /note="Helical; Name=Segment S1"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 99..125; /note="Helical; Name=Segment S2"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 130..153; /note="Helical; Name=Segment S3"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 157..175; /note="Helical; Name=Segment S4"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 189..212; /note="Helical; Name=Segment S5"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 256..283; /note="Helical; Name=Segment S6"; /evidence="ECO:0000269|PubMed:34225353
uniprot
proteins