TMEFF2
entrez
23671
canonical
uniprot
Q9UIK5
canonical
ensembl
ENSG00000144339
resolver
ensp
ENSP00000272771
resolver
ensp
ENSP00000376128
resolver
ensp
ENSP00000386871
resolver
ensp
ENSP00000547118
resolver
ensp
ENSP00000766140
resolver
ensp
ENSP00000786331
resolver
genesymbol
TMEFF2
resolver
genesymbol_syn
HPP1
resolver
genesymbol_syn
TENB2
resolver
genesymbol_syn
TPEF
resolver
hgnc
HGNC:11867
resolver
uniprot
Q2FA44
resolver
uniprot
Q4ZFW4
resolver
uniprot
Q53H90
resolver
uniprot
Q53RE1
resolver
uniprot
Q8N2R5
resolver
uniprot
Q9NR15
resolver
uniprot
Q9NSS5
resolver
uniprot
Q9P2Y9
resolver
uniprot
Q9UK65
resolver
uniprot_entry
TEFF2_HUMAN
resolver
uniprot_sec
Q2FA44
resolver
uniprot_sec
Q4ZFW4
resolver
uniprot_sec
Q53H90
resolver
uniprot_sec
Q53RE1
resolver
uniprot_sec
Q8N2R5
resolver
uniprot_sec
Q9NR15
resolver
uniprot_sec
Q9NSS5
resolver
uniprot_sec
Q9P2Y9
resolver
uniprot_sec
Q9UK65
resolver
amino_acid_sequence
MVLWESPRQCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRKCPRSNRIHRQKQNTGHYSSDNTTRASTRLI
uniprot
proteins
function
FUNCTION: May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. {ECO:0000269|PubMed:10903839, ECO:0000269|PubMed:17942404}.
uniprot
proteins
mass_dalton
41428
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains chondroitin sulfate glycosaminoglycans. {ECO:0000269|PubMed:11668495}.; PTM: A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or pro-inflammatory cytokines such as TNFalpha, and is mediated by ADAM17.
uniprot
proteins
protein_family
Tomoregulin family
uniprot
proteins
pubmed
10600548
uniprot
proteins
pubmed
10903839
uniprot
proteins
pubmed
10987305
uniprot
proteins
pubmed
11120884
uniprot
proteins
pubmed
11668495
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16439095
uniprot
proteins
pubmed
16805794
uniprot
proteins
pubmed
17942404
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19139490
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 321..341; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins