GPR171
entrez
29909
canonical
uniprot
O14626
canonical
ensembl
ENSG00000174946
resolver
ensp
ENSP00000308479
resolver
ensp
ENSP00000482588
resolver
enst
ENST00000309180
resolver
enst
ENST00000617554
resolver
genesymbol
GPR171
resolver
genesymbol_syn
H963
resolver
hgnc
HGNC:30057
resolver
uniprot
D3DNJ4
resolver
uniprot
Q8IV06
resolver
uniprot_entry
GP171_HUMAN
resolver
uniprot_sec
D3DNJ4
resolver
uniprot_sec
Q8IV06
resolver
amino_acid_sequence
MTNSSFFCPVYKDLEPFTYFFYLVFLVGIIGSCFATWAFIQKNTNHRCVSIYLINLLTADFLLTLALPVKIVVDLGVAPWKLKIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLTHSCKIYRIQEPGFAKMISTVVWLMVLLIMVPNMMIPIKDIKEKSNVGCMEFKKEFGRNWHLLTNFICVAIFLNFSAIILISNCLVIRQLYRNKDNENYPNVKKALINILLVTTGYIICFVPYHIVRIPYTLSQTEVITDCSTRISLFKAKEATLLLAVSNLCFDPILYYHLSKAFRSKVTETFASPKETKAQKEKLRCENNA
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception (By similarity). Acts as a negative regulator T cell function (PubMed:34615877). {ECO:0000250|UniProtKB:Q8BG55, ECO:0000269|PubMed:34615877}.
uniprot
proteins
mass_dalton
36754
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11524702
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
34615877
uniprot
proteins
pubmed
9370294
uniprot
proteins
sequence_length
319
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BG55}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalized with GPR83 in the paraventricular nucleus. {ECO:0000250|UniProtKB:Q8BG55}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 49..69; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 133..153; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 182..202; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins