Anapc13
entrez
69010
canonical
uniprot
Q8R034
canonical
ensembl
ENSMUSG00000035048
resolver
ensp
ENSMUSP00000039761
resolver
ensp
ENSMUSP00000139762
resolver
ensp
ENSMUSP00000140325
resolver
ensp
ENSMUSP00000140967
resolver
ensp
ENSMUSP00000215239
resolver
enst
ENSMUST00000038673
resolver
enst
ENSMUST00000186693
resolver
enst
ENSMUST00000188398
resolver
enst
ENSMUST00000190279
resolver
genesymbol
Anapc13
resolver
uniprot_entry
APC13_MOUSE
resolver
amino_acid_sequence
MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLSELPEPEQDNGGTTESVKEQEMKWTDLALQGLHENVPPAGN
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). {ECO:0000250|UniProtKB:Q9BS18}.
uniprot
proteins
mass_dalton
8346
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9BS18}.
uniprot
proteins
protein_family
APC13 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
74
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins