H2AB1
entrez
474382
canonical
uniprot
P0C5Y9
canonical
ensembl
ENSG00000274183
resolver
ensp
ENSP00000484261
resolver
enst
ENST00000620016
resolver
genesymbol
H2AB1
resolver
genesymbol_syn
H2AFB1
resolver
hgnc
HGNC:22516
resolver
uniprot
A0PK90
resolver
uniprot
P98176
resolver
uniprot
Q5TZB2
resolver
uniprot
Q6FG78
resolver
uniprot
Q96PR7
resolver
uniprot_entry
H2AB1_HUMAN
resolver
uniprot_sec
A0PK90
resolver
uniprot_sec
P98176
resolver
uniprot_sec
Q5TZB2
resolver
uniprot_sec
Q6FG78
resolver
uniprot_sec
Q96PR7
resolver
amino_acid_sequence
MPRRRRRRGSSGAGGRGRTCSRTVRAELSFSVSQVERSLREGHYAQRLSRTAPVYLAAVIEYLTAKVPELAGNEAQNSGERNITPLLLDMVVHNDRLLSTLFNTTTISQVAPGED
uniprot
proteins
function
FUNCTION: Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PubMed:22795134). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15257289, PubMed:16287874, PubMed:16957777, PubMed:17591702, PubMed:17726088, PubMed:18329190, PubMed:22795134). Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo (PubMed:15257289, PubMed:16957777, PubMed:17591702, PubMed:24336483). They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase (PubMed:17591702, PubMed:24753410). They associate with spliceosome components and are required for mRNA splicing (PubMed:22795134). {ECO:0000269|PubMed:15257289, ECO:0000269|PubMed:16287874, ECO:0000269|PubMed:16957777, ECO:0000269|PubMed:17591702, ECO:0000269|PubMed:17726088, ECO:0000269|PubMed:18329190, ECO:0000269|PubMed:22795134, ECO:0000269|PubMed:24336483, ECO:0000269|PubMed:24753410}.
uniprot
proteins
mass_dalton
12697
uniprot
proteins
protein_family
Histone H2A family
uniprot
proteins
pubmed
15257289
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16287874
uniprot
proteins
pubmed
16957777
uniprot
proteins
pubmed
17591702
uniprot
proteins
pubmed
17726088
uniprot
proteins
pubmed
18329190
uniprot
proteins
pubmed
20008104
uniprot
proteins
pubmed
22795134
uniprot
proteins
pubmed
24336483
uniprot
proteins
pubmed
24753410
uniprot
proteins
pubmed
26166249
uniprot
proteins
pubmed
8528212
uniprot
proteins
sequence_length
115
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20008104, ECO:0000269|PubMed:24336483}. Chromosome {ECO:0000269|PubMed:20008104, ECO:0000269|PubMed:22795134, ECO:0000269|PubMed:24336483}. Note=Associated with the active X chromosome and with autosomes, while it is absent from the inactive X chromosome and excluded from Barr bodies. {ECO:0000269|PubMed:20008104}.
uniprot
proteins