Cryab
entrez
12955
canonical
uniprot
P23927
canonical
ensembl
ENSMUSG00000032060
resolver
ensp
ENSMUSP00000034562
resolver
ensp
ENSMUSP00000149759
resolver
ensp
ENSMUSP00000149803
resolver
ensp
ENSMUSP00000150669
resolver
ensp
ENSMUSP00000163909
resolver
ensp
ENSMUSP00000163925
resolver
enst
ENSMUST00000034562
resolver
enst
ENSMUST00000214962
resolver
enst
ENSMUST00000216755
resolver
enst
ENSMUST00000217475
resolver
genesymbol
Cryab
resolver
genesymbol_syn
Crya2
resolver
uniprot
Q52L78
resolver
uniprot
Q64325
resolver
uniprot_entry
CRYAB_MOUSE
resolver
uniprot_entry
Q52L78_MOUSE
resolver
uniprot_sec
Q64325
resolver
amino_acid_sequence
MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFSTATSLSPFYLRPPSFLRAPSWIDTGLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVAAAPKK
uniprot
proteins
function
FUNCTION: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (PubMed:31786107). {ECO:0000269|PubMed:31786107}.
uniprot
proteins
mass_dalton
20069
uniprot
proteins
protein_family
Small heat shock protein (HSP20) family
uniprot
proteins
pubmed
10751411
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1846673
uniprot
proteins
pubmed
19538478
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2725488
uniprot
proteins
pubmed
31786107
uniprot
proteins
pubmed
7838723
uniprot
proteins
sequence_length
175
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P02511}. Nucleus {ECO:0000250|UniProtKB:P02511}. Secreted {ECO:0000250|UniProtKB:P02511}. Lysosome {ECO:0000305|PubMed:31786107}. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. Localizes at the Z-bands and the intercalated disk in cardiomyocytes. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000250|UniProtKB:P02511}.
uniprot
proteins