Them4
entrez
75778
canonical
uniprot
Q3UUI3
canonical
ensembl
ENSMUSG00000028145
resolver
ensp
ENSMUSP00000062841
resolver
enst
ENSMUST00000049822
resolver
genesymbol
Them4
resolver
genesymbol_syn
Ctmp
resolver
uniprot
A3KPD5
resolver
uniprot
Q8BYS9
resolver
uniprot
Q8R234
resolver
uniprot
Q9D5Y3
resolver
uniprot_entry
THEM4_MOUSE
resolver
uniprot_sec
A3KPD5
resolver
uniprot_sec
Q8BYS9
resolver
uniprot_sec
Q8R234
resolver
uniprot_sec
Q9D5Y3
resolver
amino_acid_sequence
MLRNCAMRLRTLGATPARRPGAARRLFSSEKVIRKDYALPNPSWTKDLRLLFDQFMKKCEDGSWKRMPSHRQNPTRAIQEFQTLFVDSKFKKEEQMSKAQQFTRSFEEGLGFEYAMFYNKVEKRTVSLFQGGLHLQGVPGFVHGGAIATIIDVTTGTCAISEGVAMTANLNITYKKPIPLLSVVVVNSQLQKIEGRKLFVSCTIQSIDEKTLYTEATALFIKLDPEKPLT
uniprot
proteins
ec_number
3.1.2.2
uniprot
proteins
function
FUNCTION: Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism (By similarity). Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (PubMed:19421406). {ECO:0000250|UniProtKB:Q5T1C6, ECO:0000269|PubMed:19421406}.
uniprot
proteins
mass_dalton
26031
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q5T1C6}.
uniprot
proteins
protein_family
THEM4/THEM5 thioesterase family
uniprot
proteins
pubmed
11598301
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19421406
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
230
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5T1C6}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q5T1C6}. Cytoplasm {ECO:0000250|UniProtKB:Q5T1C6}. Mitochondrion {ECO:0000269|PubMed:19421406}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q5T1C6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q5T1C6}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q5T1C6}. Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli. {ECO:0000250|UniProtKB:Q5T1C6}.
uniprot
proteins