TMEM198
entrez
130612
canonical
uniprot
Q66K66
canonical
ensembl
ENSG00000188760
resolver
ensp
ENSP00000343507
resolver
ensp
ENSP00000362990
resolver
ensp
ENSP00000589866
resolver
ensp
ENSP00000589867
resolver
ensp
ENSP00000589868
resolver
enst
ENST00000344458
resolver
enst
ENST00000373883
resolver
enst
ENST00000919807
resolver
enst
ENST00000919808
resolver
enst
ENST00000919809
resolver
genesymbol
TMEM198
resolver
hgnc
HGNC:33704
resolver
uniprot_entry
TM198_HUMAN
resolver
amino_acid_sequence
MPGTVATLRFQLLPPEPDDAFWGAPCEQPLERRYQALPALVCIMCCLFGVVYCFFGYRCFKAVLFLTGLLFGSVVIFLLCYRERVLETQLSAGASAGIALGIGLLCGLVAMLVRSVGLFLVGLLLGLLLAAAALLGSAPYYQPGSVWGPLGLLLGGGLLCALLTLRWPRPLTTLATAVTGAALIATAADYFAELLLLGRYVVERLRAAPVPPLCWRSWALLALWPLLSLMGVLVQWRVTAEGDSHTEVVISRQRRRVQLMRIRQQEDRKEKRRKKRPPRAPLRGPRAPPRPGPPDPAYRRRPVPIKRFNGDVLSPSYIQSFRDRQTGSSLSSFMASPTDADYEYGSRGPLTACSGPPVRV
uniprot
proteins
function
FUNCTION: Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity. {ECO:0000269|PubMed:21536646}.
uniprot
proteins
mass_dalton
39475
uniprot
proteins
protein_family
TMEM198 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21536646
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Largely located to vesicle-like structures. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 59..79; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 145..165; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 218..238; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins