OSTC
entrez
58505
canonical
uniprot
Q9NRP0
canonical
ensembl
ENSG00000198856
resolver
ensp
ENSP00000354676
resolver
ensp
ENSP00000426167
resolver
ensp
ENSP00000478564
resolver
enst
ENST00000613215
resolver
genesymbol
OSTC
resolver
hgnc
HGNC:24448
resolver
uniprot
A0A087WUD3
resolver
uniprot
A8MYS2
resolver
uniprot
B2R5H1
resolver
uniprot
D6RH22
resolver
uniprot
Q9P075
resolver
uniprot
Q9P1R4
resolver
uniprot_entry
A0A087WUD3_HUMAN
resolver
uniprot_entry
OSTC_HUMAN
resolver
uniprot_sec
A8MYS2
resolver
uniprot_sec
B2R5H1
resolver
uniprot_sec
D6RH22
resolver
uniprot_sec
Q9P075
resolver
uniprot_sec
Q9P1R4
resolver
amino_acid_sequence
METLYRVPFLVLECPNLKLKKPPWLHMPSAMTVYALVVVSYFLITGGIIYDVIVEPPSVGSMTDEHGHQRPVAFLAYRVNGQYIMEGLASSFLFTMGGLGFIILDRSNAPNIPKLNRFLLLFIGFVCVLLSFFMARVFMRMKLPGYLMG
uniprot
proteins
function
FUNCTION: Subunit of STT3A-containing oligosaccharyl transferase (OST-A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:28860277, PubMed:31831667, PubMed:39509507). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER) (PubMed:28860277, PubMed:31831667, PubMed:39509507). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex (PubMed:28860277). May be involved in N-glycosylation of APP (amyloid-beta precursor protein) (PubMed:21768116). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1 (PubMed:21768116). {ECO:0000269|PubMed:21768116, ECO:0000269|PubMed:28860277, ECO:0000269|PubMed:31831667, ECO:0000269|PubMed:39509507}.
uniprot
proteins
mass_dalton
16829
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:28860277, ECO:0000269|PubMed:31831667, ECO:0000269|PubMed:39509507}.
uniprot
proteins
protein_family
OSTC family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15146197
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21768116
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28860277
uniprot
proteins
pubmed
31831667
uniprot
proteins
pubmed
36697828
uniprot
proteins
pubmed
38670073
uniprot
proteins
pubmed
39509507
uniprot
proteins
sequence_length
149
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:21768116}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..53; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins