Gigyf2
entrez
227331
canonical
uniprot
Q6Y7W8
canonical
ensembl
ENSMUSG00000048000
resolver
ensp
ENSMUSP00000027475
resolver
ensp
ENSMUSP00000133327
resolver
ensp
ENSMUSP00000134077
resolver
ensp
ENSMUSP00000313345
resolver
ensp
ENSMUSP00000313346
resolver
enst
ENSMUST00000172794
resolver
genesymbol
Gigyf2
resolver
genesymbol_syn
Kiaa0642
resolver
genesymbol_syn
Perq2
resolver
genesymbol_syn
Tnrc15
resolver
uniprot
G3UYG6
resolver
uniprot
Q0VGQ7
resolver
uniprot
Q3UNS2
resolver
uniprot
Q63ZU9
resolver
uniprot
Q80TV1
resolver
uniprot
Q8C585
resolver
uniprot
Q8K0R0
resolver
uniprot
Q8R0A3
resolver
uniprot_entry
G3UYG6_MOUSE
resolver
uniprot_entry
GGYF2_MOUSE
resolver
uniprot_entry
Q8C585_MOUSE
resolver
uniprot_sec
Q0VGQ7
resolver
uniprot_sec
Q3UNS2
resolver
uniprot_sec
Q63ZU9
resolver
uniprot_sec
Q80TV1
resolver
uniprot_sec
Q8K0R0
resolver
uniprot_sec
Q8R0A3
resolver
amino_acid_sequence
MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDYKIPFDLLEKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGRPNFEESGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSTGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEERSDSDSSHNEEAKEPDKTNRREGEKTDRAGAEASEEVPQTSLSSARPGTPSDHQPQEATQFERKDEPKAEQVEKAEEENRSENSLSAKVPSRGDETVPASQQPSTPLPPDTASPLLILSPPVPTPSSASRPVETAAVEAPGMSSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLTSKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQALKMRMSDQNIIPSVTRSVSVPDTGSIWELQPAASQPAVWEGGSVWDLPLDTTAPGPSLEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELELQRQKDLMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTATCQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQQKLSGWGNVSKPAGTTKSLLEIQQEEARQMQKQQQQQQQQQQQHQQSNRARNSTHSNLHTSLGNSVWGSINTGPSNQWASELVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYTRAYLGDTSEAKEFAKQFLERRAKQKVNQQRQQQQQQQQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETLDDY
uniprot
proteins
function
FUNCTION: Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:26763119). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:26763119). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (By similarity). {ECO:0000250|UniProtKB:Q6Y7W6, ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:26763119}.
uniprot
proteins
mass_dalton
149193
uniprot
proteins
protein_family
GIGYF family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
12771153
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19744960
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
26763119
uniprot
proteins
sequence_length
1291
uniprot
proteins