LIPC
entrez
3990
canonical
uniprot
P11150
canonical
ensembl
ENSG00000166035
resolver
ensp
ENSP00000299022
resolver
ensp
ENSP00000348425
resolver
ensp
ENSP00000571698
resolver
ensp
ENSP00000571704
resolver
ensp
ENSP00000571705
resolver
ensp
ENSP00000571707
resolver
ensp
ENSP00000571708
resolver
ensp
ENSP00000571711
resolver
enst
ENST00000299022
resolver
enst
ENST00000356113
resolver
enst
ENST00000901639
resolver
enst
ENST00000901645
resolver
enst
ENST00000901646
resolver
enst
ENST00000901648
resolver
enst
ENST00000901649
resolver
enst
ENST00000901652
resolver
genesymbol
LIPC
resolver
genesymbol_syn
HTGL
resolver
hgnc
HGNC:6619
resolver
uniprot
A2RUB4
resolver
uniprot
A6H8L5
resolver
uniprot
A8K9B6
resolver
uniprot
O43571
resolver
uniprot
P78529
resolver
uniprot
Q99465
resolver
uniprot_entry
A6H8L5_HUMAN
resolver
uniprot_entry
LIPC_HUMAN
resolver
uniprot_sec
A2RUB4
resolver
uniprot_sec
A8K9B6
resolver
uniprot_sec
O43571
resolver
uniprot_sec
P78529
resolver
uniprot_sec
Q99465
resolver
activity_regulation
ACTIVITY REGULATION: Phospholipase A1 and triacylglycerol lipase are inhibited by sphingomyelin. {ECO:0000269|PubMed:26193433}.
uniprot
proteins
amino_acid_sequence
MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQGCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQFINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKWENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQEKIFVKCEIKSKTSKRKIR
uniprot
proteins
disease_involvement
DISEASE: Hepatic lipase deficiency (HL deficiency) [MIM:614025]: A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins. {ECO:0000269|PubMed:10660332, ECO:0000269|PubMed:1301939}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.1.3
uniprot
proteins
ec_number
3.1.1.32
uniprot
proteins
ec_number
3.1.1.5
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (PubMed:12032167, PubMed:26193433, PubMed:7592706, PubMed:8798474). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (PubMed:26193433). {ECO:0000250|UniProtKB:P07867, ECO:0000269|PubMed:12032167, ECO:0000269|PubMed:26193433, ECO:0000269|PubMed:7592706, ECO:0000269|PubMed:8798474}.
uniprot
proteins
mass_dalton
55914
uniprot
proteins
mutagenesis
MUTAGEN 255..276; /note="HFLELYRHIAQHGFNAITQTIK->CFHLEYLRIHQAHGFNATIQTKI: Loss of triglyceride hydrolase and phospholipase activity."; /evidence="ECO:0000269|PubMed:7592706"; MUTAGEN 255..275; /note="HFLELYRHIAQHGFNAITQTI->NIGEAIRVIAERGLGDVDQLV: Increased triglyceride hydrolase and reduced phospholipase activity."; /evidence="ECO:0000269|PubMed:7592706
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
Lipase family
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
10660332
uniprot
proteins
pubmed
12032167
uniprot
proteins
pubmed
12966036
uniprot
proteins
pubmed
1301939
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15126514
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
18364377
uniprot
proteins
pubmed
2324091
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2447084
uniprot
proteins
pubmed
2605236
uniprot
proteins
pubmed
26193433
uniprot
proteins
pubmed
2828141
uniprot
proteins
pubmed
2839510
uniprot
proteins
pubmed
7592706
uniprot
proteins
pubmed
8798474
uniprot
proteins
pubmed
8865180
uniprot
proteins
sequence_length
499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2828141}.
uniprot
proteins