SMC6
entrez
79677
canonical
uniprot
Q96SB8
canonical
ensembl
ENSG00000163029
resolver
ensp
ENSP00000323439
resolver
ensp
ENSP00000404092
resolver
ensp
ENSP00000531936
resolver
ensp
ENSP00000630909
resolver
ensp
ENSP00000659262
resolver
ensp
ENSP00000659264
resolver
genesymbol
SMC6
resolver
genesymbol_syn
SMC6L1
resolver
hgnc
HGNC:20466
resolver
uniprot
A0A2S1ZR87
resolver
uniprot
A8K8Q6
resolver
uniprot
D6W518
resolver
uniprot
Q05BV4
resolver
uniprot
Q9H0X3
resolver
uniprot
Q9H6M0
resolver
uniprot_entry
A0A2S1ZR87_HUMAN
resolver
uniprot_entry
SMC6_HUMAN
resolver
uniprot_sec
A8K8Q6
resolver
uniprot_sec
D6W518
resolver
uniprot_sec
Q05BV4
resolver
uniprot_sec
Q9H0X3
resolver
uniprot_sec
Q9H6M0
resolver
amino_acid_sequence
MAKRKEENFSSPKNAKRPRQEELEDFDKDGDEDECKGTTLTAAEVGIIESIHLKNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVKDGQNSADISITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFRPVTQEEDDDQR
uniprot
proteins
function
FUNCTION: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:26983541}.
uniprot
proteins
mass_dalton
126326
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:11408570}.; PTM: Sumoylated by NSMCE2/MMS21. {ECO:0000269|PubMed:16055714, ECO:0000269|PubMed:18086888}.; PTM: Ubiquitinated. {ECO:0000269|PubMed:18086888}.; PTM: (Microbial infection) SMC5-SMC6 complex is degraded by the activity of Hepatitis B X protein. {ECO:0000269|PubMed:26983541}.
uniprot
proteins
protein_family
SMC family
uniprot
proteins
protein_family
SMC6 subfamily
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11408570
uniprot
proteins
pubmed
14701739
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16055714
uniprot
proteins
pubmed
16810316
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17589526
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18086888
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25931565
uniprot
proteins
pubmed
26983541
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
35263599
uniprot
proteins
pubmed
35914008
uniprot
proteins
pubmed
36373674
uniprot
proteins
sequence_length
1091
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11408570, ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:35263599, ECO:0000269|PubMed:35914008}. Nucleus speckle {ECO:0000269|PubMed:11408570}. Chromosome {ECO:0000250|UniProtKB:Q924W5}. Nucleus, PML body {ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:36373674}. Chromosome, telomere {ECO:0000269|PubMed:17589526}. Note=Colocalizes with SMC5 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (By similarity). Localizes to PML nuclear bodies in ALT cell lines (PubMed:17589526). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). Localizes in interchromatin granule clusters (PubMed:11408570). {ECO:0000250|UniProtKB:Q924W5, ECO:0000269|PubMed:11408570, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:25931565}.
uniprot
proteins