NFATC4
entrez
4776
canonical
uniprot
Q14934
canonical
ensembl
ENSG00000100968
resolver
ensembl
ENSG00000285485
resolver
ensp
ENSP00000250373
resolver
ensp
ENSP00000388910
resolver
ensp
ENSP00000396788
resolver
ensp
ENSP00000450686
resolver
ensp
ENSP00000451151
resolver
ensp
ENSP00000451454
resolver
ensp
ENSP00000452039
resolver
ensp
ENSP00000452349
resolver
genesymbol
NFATC4
resolver
genesymbol_syn
NFAT3
resolver
hgnc
HGNC:7778
resolver
uniprot
B4DDG5
resolver
uniprot
B4DY55
resolver
uniprot
B5B2U7
resolver
uniprot
B5B2U8
resolver
uniprot
B5B2U9
resolver
uniprot
B5B2V0
resolver
uniprot
B5B2V1
resolver
uniprot
B5B2V2
resolver
uniprot
B5B2V3
resolver
uniprot
B5B2V4
resolver
uniprot
B5B2V5
resolver
uniprot
B5B2V7
resolver
uniprot
B5B2V8
resolver
uniprot
B5B2V9
resolver
uniprot
B5B2W0
resolver
uniprot
B5B2W1
resolver
uniprot
B5B2W2
resolver
uniprot
B5B2W3
resolver
uniprot
B5B2W4
resolver
uniprot
B5B2W5
resolver
uniprot
B5B2W6
resolver
uniprot
B5B2W7
resolver
uniprot
B5B2W8
resolver
uniprot
B5B2W9
resolver
uniprot
B5B2X0
resolver
uniprot
Q7Z598
resolver
uniprot
Q96H68
resolver
uniprot_entry
NFAC4_HUMAN
resolver
uniprot_sec
B4DDG5
resolver
uniprot_sec
B4DY55
resolver
uniprot_sec
B5B2U7
resolver
uniprot_sec
B5B2U8
resolver
uniprot_sec
B5B2U9
resolver
uniprot_sec
B5B2V0
resolver
uniprot_sec
B5B2V1
resolver
uniprot_sec
B5B2V2
resolver
uniprot_sec
B5B2V3
resolver
uniprot_sec
B5B2V4
resolver
uniprot_sec
B5B2V5
resolver
uniprot_sec
B5B2V7
resolver
uniprot_sec
B5B2V8
resolver
uniprot_sec
B5B2V9
resolver
uniprot_sec
B5B2W0
resolver
uniprot_sec
B5B2W1
resolver
uniprot_sec
B5B2W2
resolver
uniprot_sec
B5B2W3
resolver
uniprot_sec
B5B2W4
resolver
uniprot_sec
B5B2W5
resolver
uniprot_sec
B5B2W6
resolver
uniprot_sec
B5B2W7
resolver
uniprot_sec
B5B2W8
resolver
uniprot_sec
B5B2W9
resolver
uniprot_sec
B5B2X0
resolver
uniprot_sec
Q7Z598
resolver
uniprot_sec
Q96H68
resolver
activity_regulation
ACTIVITY REGULATION: Transcriptional activity may be repressed by ESR1 and ESR2. {ECO:0000269|PubMed:18668201}.
uniprot
proteins
amino_acid_sequence
MGAASCEDEELEFKLVFGEEKEAPPLGAGGLGEELDSEDAPPCCRLALGEPPPYGAAPIGIPRPPPPRPGMHSPPPRPAPSPGTWESQPARSVRLGGPGGGAGGAGGGRVLECPSIRITSISPTPEPPAALEDNPDAWGDGSPRDYPPPEGFGGYREAGGQGGGAFFSPSPGSSSLSSWSFFSDASDEAALYAACDEVESELNEAASRFGLGSPLPSPRASPRPWTPEDPWSLYGPSPGGRGPEDSWLLLSAPGPTPASPRPASPCGKRRYSSSGTPSSASPALSRRGSLGEEGSEPPPPPPLPLARDPGSPGPFDYVGAPPAESIPQKTRRTSSEQAVALPRSEEPASCNGKLPLGAEESVAPPGGSRKEVAGMDYLAVPSPLAWSKARIGGHSPIFRTSALPPLDWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHPVVKLLGYSEKPLTLQMFIGTADERNLRPHAFYQVHRITGKMVATASYEAVVSGTKVLEMTLLPENNMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGGGKVVSVQAASVPIECSQRSAQELPQVEAYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGPDGKLQWEEEATVNRLQSNEVTLTLTVPEYSNKRVSRPVQVYFYVSNGRRKRSPTQSFRFLPVICKEEPLPDSSLRGFPSASATPFGTDMDFSPPRPPYPSYPHEDPACETPYLSEGFGYGMPPLYPQTGPPPSYRPGLRMFPETRGTTGCAQPPAVSFLPRPFPSDPYGGRGSSFSLGLPFSPPAPFRPPPLPASPPLEGPFPSQSDVHPLPAEGYNKVGPGYGPGEGAPEQEKSRGGYSSGFRDSVPIQGITLEEVSEIIGRDLSGFPAPPGEEPPA
uniprot
proteins
function
FUNCTION: Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}.
uniprot
proteins
mass_dalton
95449
uniprot
proteins
mutagenesis
MUTAGEN 168; /note="S->A: Promotes nuclear localization and increases transcriptional activity; when associated with A-170."; /evidence="ECO:0000269|PubMed:11997522"; MUTAGEN 170; /note="S->A: Promotes nuclear localization and increases transcriptional activity; when associated with A-168."; /evidence="ECO:0000269|PubMed:11997522"; MUTAGEN 213; /note="S->A: Marked decrease in phosphorylation by MAPK8 or MAPK9. Complete loss of phosphorylation by MAPK8 or MAPK9, but no effect on MAPK8/9-binding; when associated with A-217. Decreased transcriptional activity; when associated with A-217."; /evidence="ECO:0000269|PubMed:17875713"; MUTAGEN 217; /note="S->A: Marked decrease in phosphorylation by MAPK8 or MAPK9. Complete loss of phosphorylation by MAPK8 or MAPK9, but no effect on MAPK8/9-binding; when associated with A-213. Decreased transcriptional activity; when associated with A-213."; /evidence="ECO:0000269|PubMed:17875713
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NFATC-kinases; dephosphorylated by calcineurin/PPP3CA. Phosphorylated on Ser-168 and Ser-170 by MTOR, IRAK1, MAPK7/ERK5 and MAPK14/p38, on Ser-213 and Ser-217 by MAPK8/JNK1 and MAPK9/JNK2, and on Ser-289 and Ser-344 by RPS6KA3 (PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18347059). Phosphorylated by GSK3B (PubMed:18347059). Phosphorylation by GSK3B markedly increases NFATC4 ubiquitination (By similarity). Phosphorylation at Ser-168 and Ser-170 is stimulated by UV irradiation (PubMed:18347059). Phosphorylation determines subcellular location: the hyperphosphorylated protein is cytosolic, while the dephosphorylated form is targeted to the nucleus. {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059}.; PTM: Ubiquitinated, leading to degradation by the proteasome. Ubiquitination may be stimulated by GSK3B-dependent phosphorylation. Polyubiquitin linkage mainly occurs through 'Lys-48'. {ECO:0000269|PubMed:19026640}.
uniprot
proteins
pubmed
10089876
uniprot
proteins
pubmed
11514544
uniprot
proteins
pubmed
11997522
uniprot
proteins
pubmed
12370307
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17213202
uniprot
proteins
pubmed
17875713
uniprot
proteins
pubmed
18218901
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18347059
uniprot
proteins
pubmed
18668201
uniprot
proteins
pubmed
18675896
uniprot
proteins
pubmed
18691762
uniprot
proteins
pubmed
19026640
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
25663301
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
7749981
uniprot
proteins
sequence_length
902
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201}. Nucleus {ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:12370307, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:18691762}. Note=When hyperphosphorylated, localizes in the cytosol. When intracellular Ca(2+) levels increase, dephosphorylation by calcineurin/PPP3CA leads to translocation into the nucleus (PubMed:11997522, PubMed:18347059). MAPK7/ERK5 and MTOR regulate NFATC4 nuclear export through phosphorylation at Ser-168 and Ser-170 (PubMed:18347059). {ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:18347059}.
uniprot
proteins