Ttll12
entrez
223723
canonical
uniprot
Q3UDE2
canonical
ensembl
ENSMUSG00000016757
resolver
ensp
ENSMUSP00000016901
resolver
enst
ENSMUST00000016901
resolver
genesymbol
Ttll12
resolver
uniprot
Q7TPC3
resolver
uniprot_entry
TTL12_MOUSE
resolver
uniprot_sec
Q7TPC3
resolver
amino_acid_sequence
MEIQSGPQPGSPGRAERLNARLLDEFVSLHGPTLRASGVPERLWGRLLHKLEHEVFDAGEMFGIMQVEEVEEAEDEAAREAQRKQPNPGGELCYKVIVTSESGVRADDPNSIFLIDHAWTCRVEHARKQLQQVPGLLHRMANLMGIEFHGEVPSPEVVALVLEEMWKFNQTYQLAHGTAEEKVPVWYIMDEFGSRIQHSDMPSFATAPFFYMPQQVAYTLLWPLRDLDTGEEVTRDFAYGEADPLIRKCMLLPWAPADMLDLSFSTPEPPAKYYQAILEENKEKLPLAISPVARPQGHVFRVHCDVQQVLGHLTHPRFTFTDSEADADIFFHFSHFKDYMKLSQESPQVLLNQFPCENLLTVKDCLASIARRAGGPEGPPWLPRTFNLRTELPQFVSYFQHRERRGEDNHWICKPWNLARSLDTHVTNNLHSIIRHRESTPKVVSKYIESPVLFLREDVGNVKFDIRYIVLLRSVRPLRLFAYDVFWLRFSNRPFALDDLDDYEKHFTVMNYDPDVVLKQVHYNEFIPQFEKQYPEFPWSDVQAEIFKAFTELFQVACAKPPPMGLCDYPSSRAMYAIDLMLNWDNHPDGKRVMQPQILEVNFNPDCERACRYHPSFFNDVFSTLFLDETDNCHVTRII
uniprot
proteins
function
FUNCTION: Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE. {ECO:0000250|UniProtKB:Q14166}.
uniprot
proteins
mass_dalton
74043
uniprot
proteins
protein_family
Tubulin--tyrosine ligase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17499049
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
639
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14166}. Midbody {ECO:0000250|UniProtKB:Q14166}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q14166}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q14166}. Nucleus {ECO:0000250|UniProtKB:Q14166}. Note=Predominantly localizes in the cytoplasm. {ECO:0000250|UniProtKB:Q14166}.
uniprot
proteins