Irag1
entrez
17540
canonical
uniprot
Q9WUX5
canonical
ensembl
ENSMUSG00000005611
resolver
ensp
ENSMUSP00000005751
resolver
ensp
ENSMUSP00000114578
resolver
ensp
ENSMUSP00000120045
resolver
enst
ENSMUST00000127935
resolver
genesymbol
Irag1
resolver
genesymbol_syn
Irag
resolver
genesymbol_syn
Mrvi1
resolver
uniprot
F6XPS5
resolver
uniprot
Q3U069
resolver
uniprot
Q3UR44
resolver
uniprot
Q9R2C5
resolver
uniprot_entry
F6XPS5_MOUSE
resolver
uniprot_entry
IRAG1_MOUSE
resolver
uniprot_entry
Q3UR44_MOUSE
resolver
uniprot_sec
Q3U069
resolver
uniprot_sec
Q9R2C5
resolver
amino_acid_sequence
MGRSLTCPFGISPACGAQASWSIFGVGTAEVPGTHSHSNQAAAMPHIPEDEEPPGEPQAAQTQDSPSAGPFPSPPTIVLTGDASSPEGETDKNLVNRAPSPHRRLSHRHLKVSTASLTSVDPSGHVIDLVNDQLPDISISEEDKKKNLALLEEAKLVSERFLTRRGRKSRSSLGDSPSAVSPNLSSGASPASSRSCSLTISTSPGLDICSGPQSPLPGAPPQQKGHEDGVSSPCPGEPNVSKGLADLKQNDQRKVSQGRLAPRSPTVEKTKELTVEQKENFDPLQHVEATPMAQASGASISGKMALNSPQPGPAEMELGRQLLKTAREGNPLPRTTAQGSGGTVSPHSLGQGSAGEPMGPKAGSKAELRSPVSRPPLIRGVSWDSSPEEPGPLLQKVLAKLPLAEEEKRFPGKAKPAKPPGLKDFQIQVQPVRMQKLTKLREEHILMRNQNLVGFKLPELSEAAEQDKGVSPELAPAAEEEESKSGLDVMPNISDILLRKLRVHKSLTGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNLTEENTEKELENFKASITSSANIWYHCEHRETYQKLLEDIAVLHRLAARLSSRAEVVGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNSSRSCGPSEDGVPRTARSMSLTMGKNMPRRRVSVAVVPKFNALNLPGQAPSSSPMPSLPALSESSNGKSSISVSPALPALLENGKTNAEANCEVGAPVPLPSCLEETSQETKAKAEEEAYSKGYQEGVKKTEELQDLKEEEEEEQKTESPEEPEEVEETQEDEKDQGSSKLEELVHFLQVMYPKLCQHWQVIWMMAAVMLVLSVVLGLYSSYNSCTEEADGPPGRSTCSAAQRDSWWSSGLQQELPAEQ
uniprot
proteins
function
FUNCTION: Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Also mediates NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (PubMed:32647060). {ECO:0000269|PubMed:10321731, ECO:0000269|PubMed:15388327, ECO:0000269|PubMed:15483626, ECO:0000269|PubMed:16990611, ECO:0000269|PubMed:32647060}.
uniprot
proteins
mass_dalton
97434
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKG1/cGKI. {ECO:0000250}.
uniprot
proteins
pubmed
10321731
uniprot
proteins
pubmed
15388327
uniprot
proteins
pubmed
15483626
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16990611
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32647060
uniprot
proteins
sequence_length
899
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15388327}. Sarcoplasmic reticulum {ECO:0000269|PubMed:15388327}.
uniprot
proteins
transmembrane_region
TRANSMEM 839..859; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins