Pcid2
entrez
234069
canonical
uniprot
Q8BFV2
canonical
ensembl
ENSMUSG00000038542
resolver
ensp
ENSMUSP00000133204
resolver
enst
ENSMUST00000164416
resolver
genesymbol
Pcid2
resolver
uniprot
Q147Z6
resolver
uniprot
Q8C951
resolver
uniprot_entry
PCID2_MOUSE
resolver
uniprot_sec
Q147Z6
resolver
uniprot_sec
Q8C951
resolver
amino_acid_sequence
MAHITINQYLQQVYEAIDTRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRIFANNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRITYKYYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTIELLRKYHLMQFSEVTKAVSEGNLLLLNEALAKHETFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMHVEDVDIDEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPLSTVC
uniprot
proteins
function
FUNCTION: Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (PubMed:20870947). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability (By similarity). Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (PubMed:29138493). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (PubMed:29138493). {ECO:0000250|UniProtKB:Q5JVF3, ECO:0000269|PubMed:20870947, ECO:0000269|PubMed:29138493}.
uniprot
proteins
mass_dalton
46132
uniprot
proteins
protein_family
CSN12 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20870947
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29138493
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5JVF3}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q5JVF3}.
uniprot
proteins