Palld
entrez
72333
canonical
uniprot
Q9ET54
canonical
ensembl
ENSMUSG00000058056
resolver
ensp
ENSMUSP00000034057
resolver
ensp
ENSMUSP00000112374
resolver
ensp
ENSMUSP00000112442
resolver
ensp
ENSMUSP00000113874
resolver
ensp
ENSMUSP00000318507
resolver
ensp
ENSMUSP00000318508
resolver
ensp
ENSMUSP00000318510
resolver
genesymbol
Palld
resolver
genesymbol_syn
Kiaa0992
resolver
uniprot
A0JNZ3
resolver
uniprot
K0BWC3
resolver
uniprot
Q69ZT7
resolver
uniprot
Q6DFX7
resolver
uniprot
Q9CWW1
resolver
uniprot_entry
K0BWC3_MOUSE
resolver
uniprot_entry
PALLD_MOUSE
resolver
uniprot_sec
A0JNZ3
resolver
uniprot_sec
Q69ZT7
resolver
uniprot_sec
Q6DFX7
resolver
uniprot_sec
Q9CWW1
resolver
amino_acid_sequence
MSETSSHDSFYDSLSDVQEEGKSADFFPGLSAFLSQEEINKSLDLARRAIDSSETEDFDSEKEISQIFSKSPISLCETPSHEEPKSGKQTSSERPQDSRRAPVQPLTGDQAERITSPGSKRKPGVSPLLASPSYIRSLRKAEKRGAKNPNPSSKPKTAQQSKAGPQSQLCDKAASFIEELTSIFREAAKPRNRSPNGESSSPDSGYLSPKNQPSALMSASASQSPTADQLDQLEMDAEVKQAQGSLCYQAHQASEETLPLAHIPHPQPQKARHLPTAPRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELYNSPDVQIHCESGELHTLVIAEAFEDDTGRYTCLATNPSGSDSTSAEVFIEGASSTDSDSESLSFISKAGAMPQAQKKTTSVSLTIGSSAPKTGVTTAVIQPLSVPVQQAHSATSYLCRPDGTTMGCLLPVFTKELQNTAASEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAEPEEICTLVIAESFPEDAGIFTCSATNDYGSVTSTAQLVITSANNENCSYDSTGEPNSDHFQHFPPPPPILETGSYELASQKPSEIQQVNSPNLGFSMAALQMQFNTAERETNGVHPSHGVNGLINGKAYGNKSPPTPTALLSPTKEPPPLLAKPKLDPLKLQQLQNQVRLEQEACAWPPAPPGVPCNSSSSGSSAPPSPPFPPPPPAFPELAACASPVPSEPMSALASRATAMQSSGSFNYARPKQFIAAQNLGPASGLPTPTSSPSSSSLPSPLSPTPRPFGRAPGPPFVEPEAMWGPSSPSPPPPPPPVFSPSAAYPVPDVFPLPPPPPPLPSSTSHCASPARFGPSQTPAAFLSALLPSQPPPVAVNALGLPKGVTPAGFPKKSSRTARIASDEEIQGTKDAVIQDLERKLRFKEDLLNNGQPRLTYEERMARRLLGADSANVFNIQEPEETAANQDAGAPRASVGGPLDGQKEYKVSSCEQRLISEIEYRLERSPVDESGDEVQDPDVPVENATAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQGRVSCTGRLMVQAVNQRGRSPRSPSGHPHARRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPIRPDSAHKMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFNLELVVAAKEAHKAPVFMEKLQNTGVADGYPVRLECRVSGVPPPQIFWKKENESLTHSTERVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDVYTQWHQQPQTTKPKKVRPSASRYAALSDQGLDIKAAFQPEASPSHLTLNSGLVESEDL
uniprot
proteins
function
FUNCTION: Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular locations. May be required for the initiation of neural tube closure. {ECO:0000269|PubMed:10931874, ECO:0000269|PubMed:15950489, ECO:0000269|PubMed:16492705, ECO:0000269|PubMed:17115415}.
uniprot
proteins
mass_dalton
152131
uniprot
proteins
post_translational_modification
PTM: Phosphorylated predominantly on serines and, to a lesser extent, on tyrosines. Phosphorylation at Ser-1143 by PKB/AKT1 modulates cytoskeletal organization and cell motility (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Myotilin/palladin family
uniprot
proteins
pubmed
10931874
uniprot
proteins
pubmed
11438925
uniprot
proteins
pubmed
14983521
uniprot
proteins
pubmed
15449545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15950489
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16164966
uniprot
proteins
pubmed
16492705
uniprot
proteins
pubmed
16868024
uniprot
proteins
pubmed
17115415
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17431131
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1408
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10931874}. Cell junction, focal adhesion {ECO:0000269|PubMed:10931874}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:10931874}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q8WX93}. Cell projection, podosome {ECO:0000250|UniProtKB:P0C5E3}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q8WX93}. Cell projection, axon {ECO:0000250|UniProtKB:P0C5E3}. Cell projection, growth cone {ECO:0000250|UniProtKB:P0C5E3}. Note=Localizes to stress fibers and Z lines (PubMed:10931874). Preferentially expressed in the excitatory presynaptic terminals (By similarity). {ECO:0000250|UniProtKB:P0C5E3, ECO:0000269|PubMed:10931874}.
uniprot
proteins