Slu7
entrez
303057
canonical
uniprot
Q80ZG5
canonical
ensembl
ENSRNOG00000003822
resolver
ensembl
ENSRNOG00055018819
resolver
ensembl
ENSRNOG00060020931
resolver
ensembl
ENSRNOG00065001219
resolver
ensp
ENSRNOP00000005132
resolver
ensp
ENSRNOP00055025935
resolver
ensp
ENSRNOP00060029810
resolver
ensp
ENSRNOP00065001126
resolver
enst
ENSRNOT00000005132
resolver
enst
ENSRNOT00055032076
resolver
enst
ENSRNOT00060036243
resolver
enst
ENSRNOT00065001610
resolver
genesymbol
Slu7
resolver
uniprot
B0BNL0
resolver
uniprot
Q6P6G1
resolver
uniprot_entry
B0BNL0_RAT
resolver
uniprot_entry
SLU7_RAT
resolver
uniprot_sec
Q6P6G1
resolver
amino_acid_sequence
MSAAAVDPVSATPMTGSKEMNLEEPKKMTREDWRKKKELEEQRKLGNAPAEVDEEGKDINPHIPQYISSVPWYIDPSKRPTLKHQRPQPEKQKQFSSSGEWYKRGVKENSITTKYRKGACENCGAMTHKRKDCFERPRRVGAKFTGTNIAPDEHIQPQLMFDYDGKRDRWNGYNPEEHMKIVEEYAKVDLAKRTLKAQKLQEELASGKLVEQANSPKHQWGEEEPNSQMEKDHNSEDEDEDKYADDIDMPGQNFDSKRRITVRNLRIREDIAKYLRNLDPNSAYYDPKTRAMRENPYANAGKNPDEVSYAGDNFVRYTGDTISMAQTQLFAWEAYDKGSEVHLQADPTKLELLYKSFKVKKEDFKEQQKESILEKYGGQEHLDAPPAELLLAQTEDYVEYSRHGTVIKGQERAVACSKYEEDVKINNHTHIWGSYWKEGRWGYKCCHSFFKYSYCTGEAGKESVNSEECIINDATGEEPVKKPQTLMELHQEKLKEEKKKKKKKKKHRKSSSDSDDDEERKQEKLKKALNAEEARLLHVKEIMQVDERKRPYNSIYETREPTEEEMEAYRMKRQRPDDPMASFLGQ
uniprot
proteins
function
FUNCTION: Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000250|UniProtKB:O95391}.
uniprot
proteins
mass_dalton
68337
uniprot
proteins
protein_family
SLU7 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15181151
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
586
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95391}. Nucleus speckle {ECO:0000250|UniProtKB:O95391}. Cytoplasm {ECO:0000250|UniProtKB:O95391}. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules. {ECO:0000250|UniProtKB:O95391}.
uniprot
proteins