Psrc1
entrez
56742
canonical
uniprot
Q9D0P7
canonical
ensembl
ENSMUSG00000068744
resolver
ensp
ENSMUSP00000088049
resolver
ensp
ENSMUSP00000099689
resolver
enst
ENSMUST00000090561
resolver
enst
ENSMUST00000102629
resolver
genesymbol
Psrc1
resolver
genesymbol_syn
Dda3
resolver
uniprot
Q8K4L8
resolver
uniprot
Q9QXY5
resolver
uniprot_entry
PSRC1_MOUSE
resolver
uniprot_sec
Q8K4L8
resolver
uniprot_sec
Q9QXY5
resolver
amino_acid_sequence
MEDLKEDIKFIVDETLDFGGLSPSDSHEEEDITVLVSPEKPLRRGLAHRSNPNEVAPALQGVRFSLGPLSPEKLEEILDEANRLAAQLEECALKDRERAGTGPGRPSPRGKPSPRRETFVLKDSPVRDLLPTVSSWSTPPPSSLAGLRSSDKKGSARAVRVASGKKPSSIKKESPTCNLFPASKSPGRSPLAQPILPPRRKTGFGARTTASPPIPVRPVPQSSASNSQCSSRLQGAAVKSSSRLPVPSAIPKPATRVPLIGRSLPPGKGALAPDSLSTQKGHPSAIGHRASVSQKTNLPTTSAARGRTTSAARGRAQPLRKAAVPGPTR
uniprot
proteins
function
FUNCTION: Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (By similarity). {ECO:0000250|UniProtKB:Q6PGN9}.
uniprot
proteins
mass_dalton
34707
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during mitosis. {ECO:0000250}.
uniprot
proteins
protein_family
PSRC1 family
uniprot
proteins
pubmed
10618717
uniprot
proteins
pubmed
12082536
uniprot
proteins
pubmed
12427559
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17310996
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12427559}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:12427559}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase (By similarity). {ECO:0000250}.
uniprot
proteins