Scn10a
entrez
20264
canonical
uniprot
Q6QIY3
canonical
ensembl
ENSMUSG00000034533
resolver
ensp
ENSMUSP00000081845
resolver
ensp
ENSMUSP00000148987
resolver
ensp
ENSMUSP00000150830
resolver
enst
ENSMUST00000084787
resolver
enst
ENSMUST00000214408
resolver
genesymbol
Scn10a
resolver
genesymbol_syn
Sns
resolver
uniprot
K3W4P8
resolver
uniprot
Q62243
resolver
uniprot
Q6EWG7
resolver
uniprot
Q6KCH7
resolver
uniprot
Q703F9
resolver
uniprot_entry
K3W4P8_MOUSE
resolver
uniprot_entry
SCNAA_MOUSE
resolver
uniprot_sec
Q62243
resolver
uniprot_sec
Q6EWG7
resolver
uniprot_sec
Q6KCH7
resolver
uniprot_sec
Q703F9
resolver
amino_acid_sequence
MEFPFGSVGTTNFRRFTPESLAEIEKQIAAHRAAKKGRPKQRGQKDKSEKPRPQLDLKACNQLPRFYGELPAELVGEPLEDLDPFYSTHRTFIVLDKSRTISRFSATWALWLFSPFNLIRRTAIKVSVHSWFSIFITVTILVNCVCMTRTDLPEKLEYAFTVVYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGAAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGLQLFKGNLKNKCIKNGTDPHKADNLSSEMAGDIFIKPGTTDPLLCGNGSDAGHCPNDYVCRKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIFLGSFYLVNLILAVVTMAYEEQSQATIAEIEAKEKKFKEALEVLQKEQEVLAALGIDTTSLYSHNGSPLAPKNANERRPRVKSRMSEGSTDDNRSLQSDPYNQRRMSFLGLSSGRRRASHSSVFHFRAPSQDVSFPDGILDDGVFHGDQESRRSSILLGRGAGQAGPLPRSPLPQSPNPGPRRGEEGQRGVPTGELATGAPEGPALDAAGQKNFLSADYLNEPFRAQRAMSVVSIMTSVIEELEESKLKCPPCLISLAQKYLIWECCPKWKKFKMVLFELVTDPFAELTITLCIVVNTVFMAMEHYPMTDAFDAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSTSKKGSLSVLRTFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTFILAIIVFIFALVGKQLLSENYGCRRDGISVWNGERLRWHMCDFFHSFLVVFRILCGEWIENMWVCMEVSQDYICLTLFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRASRAITSYIRSHCRLRWPKVETQLGMKPPLTSCKAENHIATDAVNAAVGNLAKPALGGPKENHGDFITDPNVWVSVPIAEGESDLDELEEDVEHASQSSWQEESPKGQQELLQQVQKCEDHQAARSPPSGMSSEDLAPYLGERWQREESPRVPAEGVDDTSSSEGSTVDCPDPEEILRKIPELAEELDEPDDCFPEGCTRRCPCCKVNTSKFPWATGWQVRKTCYRIVEHSWFESFIIFMILLSSGALAFEDNYLEEKPRVKSVLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILEYSDVASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFSRCVDTRSNPFSVVNSTFVTNKSDCYNQNNTGHFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSRDINSQPNWEESLYMYLYFVVFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFVFDIVTRQAFDIIIMALICLNMITMMVETDNQSEEKTKVLGRINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVILSISSLLFSAILSSLESYFSPTLLRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMASFANVIDEAGIDDMFNFKTFGNSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNRPNSNGSKGNCGSPAVGILFFTTYIIISFLIVVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFIAFSALSDFADTLSGPLRIPKPNQNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKTNMEEKFMATNLSKASYEPIATTLRCKQEDISATIIQKAYRNYMLQRSLMLSNPLHVPRAEEDGVSLPREGYVTFMANDNGGLPDKSETASATSFPPSYDSVTRGLSDRANISTSSSMQNEDEVTAKEGKSPGPQ
uniprot
proteins
function
FUNCTION: Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. {ECO:0000269|PubMed:24159039}.
uniprot
proteins
mass_dalton
220552
uniprot
proteins
mutagenesis
MUTAGEN 861; /note="Q->E: Sensitive to inhibition by some components of the venom of Centruroides sculpturatus."; /evidence="ECO:0000269|PubMed:24159039"; MUTAGEN 1922; /note="Y->A: No regulation by NEDD4L."; /evidence="ECO:0000269|PubMed:15123669
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by NEDD4L; which promotes its endocytosis. {ECO:0000305}.; PTM: Phosphorylation at Ser-1452 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. {ECO:0000250}.; PTM: Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 815) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4. {ECO:0000250|UniProtKB:P15389}.
uniprot
proteins
protein_family
Nav1.8/SCN10A subfamily
uniprot
proteins
protein_family
Sodium channel (TC 1.A.1.10) family
uniprot
proteins
pubmed
15047701
uniprot
proteins
pubmed
15123669
uniprot
proteins
pubmed
24159039
uniprot
proteins
sequence_length
1958
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:D0E0C2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}. Note=It can be translocated to the cell membrane through association with S100A10. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 126..149; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 155..174; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 188..206; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 213..232; /note="Helical; Voltage-sensor; Name=S4 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 249..272; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 373..398; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 659..683; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 695..718; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 727..746; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 753..772; /note="Helical; Voltage-sensor; Name=S4 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 789..809; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 864..889; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 1149..1172; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1186..1211; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1218..1239; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1244..1265; /note="Helical; Voltage-sensor; Name=S4 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1285..1312; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1393..1419; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1473..1496; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1508..1531; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1538..1561; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1574..1595; /note="Helical; Voltage-sensor; Name=S4 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1611..1633; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1699..1723; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000255
uniprot
proteins