PRAMEF6
entrez
440561
canonical
uniprot
Q5VXH4
canonical
ensembl
ENSG00000232423
resolver
ensembl
ENSG00000282119
resolver
ensp
ENSP00000365360
resolver
ensp
ENSP00000401281
resolver
ensp
ENSP00000487731
resolver
ensp
ENSP00000488780
resolver
enst
ENST00000376189
resolver
enst
ENST00000415464
resolver
enst
ENST00000632295
resolver
enst
ENST00000632388
resolver
genesymbol
PRAMEF6
resolver
hgnc
HGNC:30583
resolver
uniprot
A0AUJ9
resolver
uniprot_entry
PRAM6_HUMAN
resolver
uniprot_sec
A0AUJ9
resolver
amino_acid_sequence
MSIRTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWPFRRLPLRPLIKMPCLEAFQAVLDGLDALLTQGVHPRRWKLQVLDLQDVCENFWMVWSEAMARGCFLNAKRNKTPVQDCPRMRGQQPLTVFVELWLKNRTLDEYLTCLLLWVKQRKDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTPYLGHMRNLQKLVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLCCLQKLSMNSVSFLEGHLDQLLSCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPISMATLENLLSHTIILKNLCVELYPAPRESYDADGTLCWSRFAQIRAELMKRVRDLRHPKRILFCTDCCPDCGNRSFYDLEADQCCC
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:26138980). The CRL2(PRAMEF6) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (PubMed:26138980). {ECO:0000269|PubMed:26138980}.
uniprot
proteins
mass_dalton
54852
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:26138980}.
uniprot
proteins
protein_family
PRAME family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
26138980
uniprot
proteins
sequence_length
476
uniprot
proteins