Acvrl1
entrez
25237
canonical
uniprot
P80203
canonical
ensembl
ENSRNOG00000028713
resolver
ensembl
ENSRNOG00055028741
resolver
ensembl
ENSRNOG00060015566
resolver
ensembl
ENSRNOG00065022556
resolver
ensp
ENSRNOP00000008673
resolver
ensp
ENSRNOP00000104153
resolver
ensp
ENSRNOP00055040972
resolver
ensp
ENSRNOP00060021306
resolver
ensp
ENSRNOP00065031204
resolver
enst
ENSRNOT00000008673
resolver
enst
ENSRNOT00055049771
resolver
enst
ENSRNOT00060026631
resolver
enst
ENSRNOT00065038495
resolver
genesymbol
Acvrl1
resolver
genesymbol_syn
Acvrlk1
resolver
uniprot
Q63559
resolver
uniprot_entry
ACVL1_RAT
resolver
uniprot_sec
Q63559
resolver
amino_acid_sequence
MTLGIFRRVFLMLSVALGLTKGDLVKPSRGQLVNCTCENPHCKRPICQGAWCTVVLVREQGRHPQVYRGCGSLNQELCLGRPTEFVNHHCCYRSFCNHNVSLMLEATQTPSEEPEVDAHLPLILGPVLALLVLVALGTLGLWRVRRRQEKQRGLHSDLGESSLILKASEQGDSMLGDFLVSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSQNPEKPKVIH
uniprot
proteins
ec_number
2.7.11.30
uniprot
proteins
function
FUNCTION: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. {ECO:0000250|UniProtKB:P37023}.
uniprot
proteins
mass_dalton
56703
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TGFB receptor subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8395914
uniprot
proteins
pubmed
8928814
uniprot
proteins
sequence_length
504
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P37023}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 122..142; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins