NELL2
entrez
4753
canonical
uniprot
Q99435
canonical
ensembl
ENSG00000184613
resolver
ensp
ENSP00000327988
resolver
ensp
ENSP00000378866
resolver
ensp
ENSP00000390680
resolver
ensp
ENSP00000394612
resolver
ensp
ENSP00000416341
resolver
ensp
ENSP00000637296
resolver
genesymbol
NELL2
resolver
genesymbol_syn
NRP2
resolver
hgnc
HGNC:7751
resolver
uniprot
B7Z2U7
resolver
uniprot
B7Z5Q4
resolver
uniprot
B7Z625
resolver
uniprot
B7Z9J5
resolver
uniprot
B7Z9U3
resolver
uniprot
Q96JS2
resolver
uniprot_entry
B7Z625_HUMAN
resolver
uniprot_entry
NELL2_HUMAN
resolver
uniprot_sec
B7Z2U7
resolver
uniprot_sec
B7Z5Q4
resolver
uniprot_sec
B7Z9J5
resolver
uniprot_sec
B7Z9U3
resolver
uniprot_sec
Q96JS2
resolver
amino_acid_sequence
MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL
uniprot
proteins
function
FUNCTION: Plays multiple roles in neural tissues, regulates neuronal proliferation, survival, differentiation, polarization, as well as axon guidance and synaptic functions. Plays an important role in axon development during neuronal differentiation through the MAPK intracellular signaling pathway (By similarity). Via binding to its receptor ROBO3, plays a role in axon guidance, functioning as a repulsive axon guidance cue that contributes to commissural axon guidance to the midline (PubMed:32198364). Required for neuron survival through the modulation of MAPK signaling pathways too. Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity). {ECO:0000250|UniProtKB:Q62918, ECO:0000269|PubMed:32198364}.; FUNCTION: Epididymal-secreted protein that signals through a ROS1-pathway to regulate the epididymal initial segment (IS) maturation, sperm maturation and male fertility. {ECO:0000250|UniProtKB:Q61220}.
uniprot
proteins
mass_dalton
91346
uniprot
proteins
mutagenesis
MUTAGEN 448; /note="R->A: Diminished binding to ROBO3; when associated with A-450."; /evidence="ECO:0000269|PubMed:32198364"; MUTAGEN 450; /note="Y->A: Diminished binding to ROBO3; when associated with A-448."; /evidence="ECO:0000269|PubMed:32198364"; MUTAGEN 452; /note="R->A: Diminished binding to ROBO3."; /evidence="ECO:0000269|PubMed:32198364"; MUTAGEN 476; /note="D->A: Abolished binding to ROBO3."; /evidence="ECO:0000269|PubMed:32198364"; MUTAGEN 477; /note="D->A: Abolished binding to ROBO3; when associated with A-478."; /evidence="ECO:0000269|PubMed:32198364"; MUTAGEN 478; /note="Y->A: Abolished binding to ROBO3; when associated with A-477."; /evidence="ECO:0000269|PubMed:32198364"; MUTAGEN 498; /note="L->A: Abolished binding to ROBO3; when associated with A-500."; /evidence="ECO:0000269|PubMed:32198364"; MUTAGEN 500; /note="F->A: Abolished binding to ROBO3; when associated with A-498."; /evidence="ECO:0000269|PubMed:32198364"; MUTAGEN 509; /note="V->A: Diminished binding to ROBO3."; /evidence="ECO:0000269|PubMed:32198364
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
32198364
uniprot
proteins
pubmed
8975702
uniprot
proteins
sequence_length
816
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q62918}.
uniprot
proteins