RFX3
entrez
5991
canonical
uniprot
P48380
canonical
ensembl
ENSG00000080298
resolver
ensp
ENSP00000303847
resolver
ensp
ENSP00000351574
resolver
ensp
ENSP00000371434
resolver
ensp
ENSP00000482598
resolver
ensp
ENSP00000546625
resolver
ensp
ENSP00000638911
resolver
ensp
ENSP00000638912
resolver
genesymbol
RFX3
resolver
hgnc
HGNC:9984
resolver
uniprot
A8K0H5
resolver
uniprot
D3DRH8
resolver
uniprot
D3DRH9
resolver
uniprot
Q5JTL7
resolver
uniprot
Q5JTL8
resolver
uniprot
Q6NW13
resolver
uniprot
Q8WTU4
resolver
uniprot
Q95HL5
resolver
uniprot
Q95HL6
resolver
uniprot_entry
RFX3_HUMAN
resolver
uniprot_sec
A8K0H5
resolver
uniprot_sec
D3DRH8
resolver
uniprot_sec
D3DRH9
resolver
uniprot_sec
Q5JTL7
resolver
uniprot_sec
Q5JTL8
resolver
uniprot_sec
Q6NW13
resolver
uniprot_sec
Q8WTU4
resolver
uniprot_sec
Q95HL5
resolver
uniprot_sec
Q95HL6
resolver
amino_acid_sequence
MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQTVQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPATIEMAIETLQKSDGLSTHRSSLLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEISSLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPTDGTTITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFGDLNAVSPGNLDKDEGSEVESEMDEELDDSSEPQAKREKTELSQAFPVGCMQPVLETGVQPSLLNPIHSEHIVTSTQTIRQCSATGNTYTAV
uniprot
proteins
function
FUNCTION: Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (PubMed:12411430). {ECO:0000250|UniProtKB:P48381, ECO:0000269|PubMed:12411430, ECO:0000269|PubMed:20148032}.
uniprot
proteins
mass_dalton
83530
uniprot
proteins
protein_family
RFX family
uniprot
proteins
pubmed
10330134
uniprot
proteins
pubmed
12411430
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20148032
uniprot
proteins
pubmed
31429579
uniprot
proteins
pubmed
8289803
uniprot
proteins
sequence_length
749
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31429579, ECO:0000305}.
uniprot
proteins