Gpr183
entrez
321019
canonical
uniprot
Q3U6B2
canonical
ensembl
ENSMUSG00000051212
resolver
ensp
ENSMUSP00000052404
resolver
enst
ENSMUST00000049872
resolver
genesymbol
Gpr183
resolver
genesymbol_syn
Ebi2
resolver
uniprot
Q3U1F6
resolver
uniprot
Q7TMV7
resolver
uniprot
Q80T40
resolver
uniprot_entry
GP183_MOUSE
resolver
uniprot_sec
Q3U1F6
resolver
uniprot_sec
Q7TMV7
resolver
uniprot_sec
Q80T40
resolver
amino_acid_sequence
MANNFTTPLATSHGNNCDLYAHHSTARVLMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSMNLVISDILFTTALPTRIAYYALGFDWRIGDALCRVTALVFYINTYAGVNFMTCLSIDRFFAVVHPLRYNKIKRIEYAKGVCLSVWILVFAQTLPLLLTPMSKEEGDKTTCMEYPNFEGTASLPWILLGACLLGYVLPITVILLCYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFILCFTPYHVAIIQHMIKMLCSPGALECGARHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMKMLKRQVSVSISSAVRSAPEENSREMTESQMMIHSKASNGR
uniprot
proteins
function
FUNCTION: G protein-coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (PubMed:19597478, PubMed:19615922, PubMed:21796211, PubMed:21796212, PubMed:21844396, PubMed:27147029). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796211, PubMed:21796212). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (PubMed:21796211, PubMed:21796212, PubMed:27147029). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (PubMed:21796211, PubMed:21796212). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:21948984, PubMed:22913878). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (PubMed:19597478, PubMed:19615922, PubMed:21844396). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (PubMed:19615922). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (PubMed:27147029). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (PubMed:27147029). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (PubMed:23502855, PubMed:23682316). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897, PubMed:27166278). Promotes osteoclast precursor migration to bone surfaces (PubMed:26438360). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (By similarity). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity). {ECO:0000250|UniProtKB:P32249, ECO:0000269|PubMed:19597478, ECO:0000269|PubMed:19615922, ECO:0000269|PubMed:21796211, ECO:0000269|PubMed:21796212, ECO:0000269|PubMed:21844396, ECO:0000269|PubMed:21948984, ECO:0000269|PubMed:22913878, ECO:0000269|PubMed:23502855, ECO:0000269|PubMed:23682316, ECO:0000269|PubMed:25297897, ECO:0000269|PubMed:26438360, ECO:0000269|PubMed:27147029, ECO:0000269|PubMed:27166278}.
uniprot
proteins
mass_dalton
40185
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19597478
uniprot
proteins
pubmed
19615922
uniprot
proteins
pubmed
21673108
uniprot
proteins
pubmed
21796211
uniprot
proteins
pubmed
21796212
uniprot
proteins
pubmed
21844396
uniprot
proteins
pubmed
21948984
uniprot
proteins
pubmed
22913878
uniprot
proteins
pubmed
23502855
uniprot
proteins
pubmed
23682316
uniprot
proteins
pubmed
25176650
uniprot
proteins
pubmed
25297897
uniprot
proteins
pubmed
26438360
uniprot
proteins
pubmed
27147029
uniprot
proteins
pubmed
27166278
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P32249}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..53; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 74..91; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 102..123; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 146..164; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 189..211; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 238..261; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 284..308; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins