Slc31a2
entrez
20530
canonical
uniprot
Q9CPU9
canonical
ensembl
ENSMUSG00000066152
resolver
ensp
ENSMUSP00000081578
resolver
ensp
ENSMUSP00000103091
resolver
ensp
ENSMUSP00000103092
resolver
enst
ENSMUST00000084530
resolver
enst
ENSMUST00000107467
resolver
enst
ENSMUST00000107468
resolver
genesymbol
Slc31a2
resolver
uniprot
F6VMZ6
resolver
uniprot
Q4KL43
resolver
uniprot
Q9D524
resolver
uniprot_entry
COPT2_MOUSE
resolver
uniprot_entry
F6VMZ6_MOUSE
resolver
uniprot_entry
Q4KL43_MOUSE
resolver
uniprot_entry
Q9D524_MOUSE
resolver
amino_acid_sequence
MPMHFIFSDEAVLLFDFWRVHSPTGMALSVLVVLLLAVLYEGIKVGKAKLLHKTLESLPATNSQQFILGPDQDSTGSRSTSDNRTRLRWFLCYFGQSLVHVIQVVIGYFVMLAVMSYNTWIFLGVVLGSAVGYYLAYPLLNMT
uniprot
proteins
function
FUNCTION: Does not function as a copper(1+) importer in vivo (PubMed:24167251). However, in vitro functions as a low-affinity copper(1+) importer (By similarity). Regulator of SLC31A1 which facilitates the cleavage of the SLC31A1 ecto-domain or which stabilizes the truncated form of SLC31A1 (Truncated CTR1 form), thereby drives the SLC31A1 truncated form-dependent endosomal copper export and modulates the copper and cisplatin accumulation via SLC31A1 (PubMed:24167251). {ECO:0000250|UniProtKB:O15432, ECO:0000269|PubMed:24167251}.
uniprot
proteins
mass_dalton
16069
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; ubiquitination and the subsequent proteasomal degradation are prevent by SLC31A1 that stabilizes it. {ECO:0000250|UniProtKB:O15432}.
uniprot
proteins
protein_family
Copper transporter (Ctr) (TC 1.A.56) family
uniprot
proteins
protein_family
SLC31A subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24167251
uniprot
proteins
sequence_length
143
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:O15432}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O15432}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000305|PubMed:24167251}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:O15432}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000305|PubMed:24167251}; Multi-pass membrane protein {ECO:0000255}. Note=Plasma membrane localization is partial (By similarity). Localizes in endosomes recycling from and to the plasma membrane, as well as in late endosomes trafficking to the trans-Golgi network (TGN) (PubMed:24167251). {ECO:0000250|UniProtKB:O15432, ECO:0000269|PubMed:24167251}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins