TMEM164
entrez
84187
canonical
uniprot
Q5U3C3
canonical
ensembl
ENSG00000157600
resolver
ensp
ENSP00000288381
resolver
ensp
ENSP00000361138
resolver
ensp
ENSP00000361143
resolver
ensp
ENSP00000384075
resolver
ensp
ENSP00000520920
resolver
ensp
ENSP00000566251
resolver
ensp
ENSP00000566253
resolver
enst
ENST00000288381
resolver
enst
ENST00000896194
resolver
genesymbol
RP13-360B22.2
resolver
genesymbol
TMEM164
resolver
hgnc
HGNC:26217
resolver
uniprot
A0ACM8PXF2
resolver
uniprot
A1PI58
resolver
uniprot
B3KSQ8
resolver
uniprot
F5H2P2
resolver
uniprot
F6RZ86
resolver
uniprot_entry
A0ACM8PXF2_HUMAN
resolver
uniprot_entry
A1PI58_HUMAN
resolver
uniprot_entry
TM164_HUMAN
resolver
uniprot_sec
B3KSQ8
resolver
uniprot_sec
F5H2P2
resolver
uniprot_sec
F6RZ86
resolver
amino_acid_sequence
MSRYSYQSLLDWLYGGVDPSFAGNGGPDCAAFLSWQQRLLESVVVLTLALLEILVALRHILRQTKEDGRGSPGSQPEQVTQRPEEGKESLSKNLLLVALCLTFGVEVGFKFATKTVIYLLNPCHLVTMMHIFLLACPPCRGAIVVFKLQMHMLNGALLALLFPVVNTRLLPFELEIYYIQHVMLYVVPIYLLWKGGAYTPEPLSSFRWALLSTGLMFFYHFSVLQILGLVTEVNLNNMLCPAISDPFYGPWYRIWASGHQTLMTMTHGKLVILFSYMAGPLCKYLLDLLRLPAKKID
uniprot
proteins
function
FUNCTION: Positive regulator of ferroptosis (PubMed:35947500, PubMed:36782012). Involved in the acylation of ether lysophospholipids with the arachidonoyl chain (5Z,8Z,11Z,14Z-eicosatetraenoyl; C20:4) of diacylglycerophospholipids, generating C20:4 ether glycerophospholipids (ePEs) such as 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine (PE (P-18:0/20:4)), which promotes ferroptosis (PubMed:36782012). Selectively mediates ATG5-dependent autophagosome formation during ferroptosis, rather than during starvation, and regulates the degradation of ferritin, GPX4 and lipid droplets to increase iron accumulation and lipid peroxidation, thereby promoting ferroptotic cell death (PubMed:35947500). {ECO:0000269|PubMed:35947500, ECO:0000269|PubMed:36782012}.
uniprot
proteins
mass_dalton
33508
uniprot
proteins
protein_family
TMEM164 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
35947500
uniprot
proteins
pubmed
36782012
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 210..230; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 262..282; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins