Bad
entrez
64639
canonical
uniprot
O35147
canonical
ensembl
ENSRNOG00000021147
resolver
ensp
ENSRNOP00000028712
resolver
ensp
ENSRNOP00000096573
resolver
enst
ENSRNOT00000028712
resolver
genesymbol
Bad
resolver
uniprot
A0A8L2UKI4
resolver
uniprot
O70256
resolver
uniprot
Q9JHX1
resolver
uniprot_entry
A0A8L2UKI4_RAT
resolver
uniprot_entry
BAD_RAT
resolver
uniprot_sec
O70256
resolver
uniprot_sec
Q9JHX1
resolver
amino_acid_sequence
MGTPKQPSLAPAHALGLRKSDPGIRSLGSDAGGRRWRPAAQSMFQIPEFEPSEQEDASTTDRGLGPSLTEDQPGPYLAPGLLGSIVQQQPGQAANNSHHGGAGTMETRSRHSSYPAGTEEDEGMEEELSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFEGSFKGLPRPKSAGTATQMRQSASWTRIIQSWWDRNLGKGGSTPSQ
uniprot
proteins
function
FUNCTION: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}.
uniprot
proteins
mass_dalton
22228
uniprot
proteins
mutagenesis
MUTAGEN 113; /note="S->A: No effect on heterodimerization with 14-3-3 proteins."; /evidence="ECO:0000269|PubMed:9369453"; MUTAGEN 137; /note="S->A: No heterodimerization with 14-3-3 proteins. No effect on heterodimerization with BCL2 nor with protein P11."; /evidence="ECO:0000269|PubMed:9369453
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at one or more of Ser-113, Ser-137, Ser-156 and Ser-171 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-137 or Ser-113 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-156, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-137 is the major site of AKT/PKB phosphorylation, Ser-156 the major site of protein kinase A (CAPK) phosphorylation.; PTM: Methylation at Arg-132 and Arg-134 by PRMT1 inhibits Akt-mediated phosphorylation at Ser-137. {ECO:0000250}.
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
11161472
uniprot
proteins
pubmed
17998337
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9369453
uniprot
proteins
pubmed
9535132
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane. Cytoplasm {ECO:0000250|UniProtKB:Q61337}. Note=Colocalizes with HIF3A in the cytoplasm. Upon phosphorylation, locates to the cytoplasm. {ECO:0000250|UniProtKB:Q61337}.
uniprot
proteins