KDELR1
entrez
10945
canonical
uniprot
P24390
canonical
ensembl
ENSG00000105438
resolver
ensp
ENSP00000329471
resolver
genesymbol
KDELR1
resolver
genesymbol_syn
ERD2.1
resolver
hgnc
HGNC:6304
resolver
uniprot
B2R6N4
resolver
uniprot
Q54A39
resolver
uniprot
Q8NBW7
resolver
uniprot_entry
ERD21_HUMAN
resolver
uniprot_sec
B2R6N4
resolver
uniprot_sec
Q54A39
resolver
uniprot_sec
Q8NBW7
resolver
amino_acid_sequence
MNLFRFLGDLSHLLAIILLLLKIWKSRSCAGISGKSQVLFAVVFTARYLDLFTNYISLYNTCMKVVYIACSFTTVWLIYSKFKATYDGNHDTFRVEFLVVPTAILAFLVNHDFTPLEILWTFSIYLESVAILPQLFMVSKTGEAETITSHYLFALGVYRTLYLFNWIWRYHFEGFFDLIAIVAGLVQTVLYCDFFYLYITKVLKGKKLSLPA
uniprot
proteins
function
FUNCTION: Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. {ECO:0000269|PubMed:11703931, ECO:0000269|PubMed:14517323, ECO:0000269|PubMed:18086916, ECO:0000269|PubMed:30846601, ECO:0000269|PubMed:8392934}.
uniprot
proteins
mass_dalton
24542
uniprot
proteins
mutagenesis
MUTAGEN 12; /note="H->A: Loss of recycling together with cargo proteins containing the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:30846601"; MUTAGEN 32; /note="I->A: Decreased binding to the sequence motif K-D-E-L."; /evidence="ECO:0000269|PubMed:8392934"; MUTAGEN 47; /note="R->K: Loss of recycling together with cargo proteins containing the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:30846601"; MUTAGEN 91..92; /note="DT->AA: Decreased binding to the sequence motif K-D-E-L."; /evidence="ECO:0000269|PubMed:8392934"; MUTAGEN 127; /note="E->A,Q: Loss of recycling together with cargo proteins containing the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:30846601"; MUTAGEN 158; /note="Y->F: Loss of recycling together with cargo proteins containing the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:30846601"; MUTAGEN 193; /note="D->N: Loss of recycling together with cargo proteins containing the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:30846601, ECO:0000269|PubMed:8392934"; MUTAGEN 204..207; /note="KGKK->AGAA: Loss of recycling together with cargo proteins containing the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:30846601"; MUTAGEN 209; /note="S->A: Inhibits coatomer/ARF-GAP recruitment, receptor redistribution, and intracellular retention of KDEL ligands."; /evidence="ECO:0000269|PubMed:14517323"; MUTAGEN 209; /note="S->D: Redistribution to the ER is not affected upon PKA inactivation."; /evidence="ECO:0000269|PubMed:14517323
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PKA at Ser-209 is required for endoplasmic reticulum retention function. {ECO:0000269|PubMed:14517323}.
uniprot
proteins
protein_family
ERD2 family
uniprot
proteins
pubmed
11703931
uniprot
proteins
pubmed
12761501
uniprot
proteins
pubmed
14517323
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18086916
uniprot
proteins
pubmed
2172835
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30846601
uniprot
proteins
pubmed
8392934
uniprot
proteins
sequence_length
212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:18086916, ECO:0000269|PubMed:2172835, ECO:0000269|PubMed:30846601, ECO:0000269|PubMed:8392934}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:18086916}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18086916, ECO:0000269|PubMed:30846601, ECO:0000269|PubMed:8392934}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:P33946}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L. {ECO:0000269|PubMed:18086916, ECO:0000269|PubMed:30846601, ECO:0000269|PubMed:8392934}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..24; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q5ZKX9"; TRANSMEM 33..52; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q5ZKX9"; TRANSMEM 59..79; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q5ZKX9"; TRANSMEM 93..110; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q5ZKX9"; TRANSMEM 117..135; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q5ZKX9"; TRANSMEM 150..168; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q5ZKX9"; TRANSMEM 179..199; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q5ZKX9
uniprot
proteins