O89043
uniprot
O89043
canonical
amino_acid_sequence
MAVSTQQLAEELQIFGLDCEDSLLEKLAELCTLYRQTEERMVSELIAFCTSAGKSCLTGEILSSFEHEVLNKKLSKACHSASKDNRHAGARDIVSIQELIEAEEEEETLLSAYTTPSKGPHKRVSSTPETPLTKRSISTRSPHQLLSPSSFSPSATPSQKYSSRTNRGEVVTTFGSAQGVSWSGRGGSGSISLKVMGYPEPLTSSYKTMFQQLPDIREVLTCKIEELGSELKEHYKIEAFTPLLVPAQEPVILLGQIGCDSNGRLNSKSVILEGDREHSSGAQIPVDVSELKDYSLFPGQVVIMEGFNTTGRRLTATKLYEGVPLPFYQPTEEEGDFEQTMVLVACGPYTTSDSITYDPLLDLISTINHDRPDVCILFGPFLDAKHEQVENCKLTSPFEDIFKQCLRTVIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFTFSELPREDKKRVQFVSEPCNLSINGVMFGLTSTDLLFHIGAEEICSSSGTSDRFSRILKHILTQRSYYPLYPPHEDMAIDYENFYTYAQLPVTPDVFIVPSELRYFVKDIFGCVCMNPGRLTKGQVGGTFGRLYLRRQPKGTDSEGRQGLSVAAQVVRI
uniprot
proteins
function
FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (By similarity). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerizing short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P20664, ECO:0000250|UniProtKB:Q14181}.
uniprot
proteins
mass_dalton
66636
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in a cell cycle-dependent manner, in G2/M phase. {ECO:0000250}.
uniprot
proteins
protein_family
DNA polymerase alpha subunit B family
uniprot
proteins
pubmed
10541966
uniprot
proteins
pubmed
11536367
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
600
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins