Abcg5
entrez
114628
canonical
uniprot
Q99PE7
canonical
ensembl
ENSRNOG00000005250
resolver
ensembl
ENSRNOG00065015140
resolver
ensp
ENSRNOP00000007174
resolver
ensp
ENSRNOP00065019644
resolver
enst
ENSRNOT00000007174
resolver
enst
ENSRNOT00065025097
resolver
genesymbol
Abcg5
resolver
uniprot
Q8CIQ4
resolver
uniprot_entry
ABCG5_RAT
resolver
uniprot_sec
Q8CIQ4
resolver
amino_acid_sequence
MSELPFLSPEGARGPHNNRGSQSSLEEGSVTGSEARHSLGVLNVSFSVSNRVGPWWNIKSCQQKWDRKILKDVSLYIESGQTMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGCELRRDQFQDCVSYLLQSDVFLSSLTVRETLRYTAMLALRSSSADFYDKKVEAVLTELSLSHVADQMIGNYNFGGISSGERRRVSIAAQLLQDPKVMMLDEPTTGLDCMTANHIVLLLVELARRNRIVIVTIHQPRSELFHHFDKIAILTYGELVFCGTPEEMLGFFNNCGYPCPEHSNPFDFYMDLTSVDTQSREREIETYKRVQMLESAFRQSDICHKILENIERTRHLKTLPMVPFKTKNPPGMFCKLGVLLRRVTRNLMRNKQVVIMRLVQNLIMGLFLIFYLLRVQNNMLKGAVQDRVGLLYQLVGATPYTGMLNAVNLFPMLRAVSDQESQDGLYQKWQMLLAYVLHALPFSIVATVIFSSVCYWTLGLYPEVARFGYFSAALLAPHLIGEFLTLVLLGMVQNPNIVNSIVALLSISGLLIGSGFIRNIEEMPIPLKILGYFTFQKYCCEILVVNEFYGLNFTCGGSNTSVPNNPMCSMTQGIQFIEKTCPGATSRFTTNFLILYSFIPTLVILGMVVFKVRDYLISR
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
function
FUNCTION: ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG8 has ATPase activity. {ECO:0000250|UniProtKB:Q9H222}.
uniprot
proteins
mass_dalton
73372
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. N-glycosylation is important for efficient export out of the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q99PE8}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCG family
uniprot
proteins
protein_family
Eye pigment precursor importer (TC 3.A.1.204) subfamily
uniprot
proteins
pubmed
11138003
uniprot
proteins
pubmed
12783625
uniprot
proteins
sequence_length
652
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H222}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H222}. Apical cell membrane {ECO:0000250|UniProtKB:Q9H222}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H222}.
uniprot
proteins
transmembrane_region
TRANSMEM 385..405; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9H222"; TRANSMEM 423..443; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9H222"; TRANSMEM 469..490; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9H222"; TRANSMEM 502..522; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9H222"; TRANSMEM 530..550; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9H222"; TRANSMEM 625..645; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9H222
uniprot
proteins