INCENP
entrez
3619
canonical
uniprot
Q9NQS7
canonical
ensembl
ENSG00000149503
resolver
ensp
ENSP00000278849
resolver
ensp
ENSP00000378295
resolver
ensp
ENSP00000557913
resolver
ensp
ENSP00000557914
resolver
ensp
ENSP00000653026
resolver
genesymbol
INCENP
resolver
hgnc
HGNC:6058
resolver
uniprot
A8MQD2
resolver
uniprot
Q5Y192
resolver
uniprot_entry
INCE_HUMAN
resolver
uniprot_sec
A8MQD2
resolver
uniprot_sec
Q5Y192
resolver
amino_acid_sequence
MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSPPLQGARVPSSLAYSLKKH
uniprot
proteins
function
FUNCTION: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}.
uniprot
proteins
mass_dalton
105429
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="F->R: Loss of binding to CDCA8 and BIRC5; when associated with R-34."; /evidence="ECO:0000269|PubMed:17956729"; MUTAGEN 34; /note="L->R: Loss of binding to CDCA8 and BIRC5; when associated with R-22."; /evidence="ECO:0000269|PubMed:17956729"; MUTAGEN 35; /note="E->R: Loss of localization to the central spindle and midbody in anaphase or cytokinesis; when associated with R-36; R-39 and R-40."; /evidence="ECO:0000269|PubMed:17956729"; MUTAGEN 36; /note="E->R: Loss of localization to the central spindle and midbody in anaphase or cytokinesis; when associated with R-35; R-39 and R-40."; /evidence="ECO:0000269|PubMed:17956729"; MUTAGEN 39; /note="E->R: Loss of localization to the central spindle and midbody in anaphase or cytokinesis; when associated with R-35; R-36 and R-40."; /evidence="ECO:0000269|PubMed:17956729"; MUTAGEN 40; /note="E->R: Loss of localization to the central spindle and midbody in anaphase or cytokinesis; when associated with R-35; R-36 and R-39."; /evidence="ECO:0000269|PubMed:17956729"; MUTAGEN 167; /note="P->A: Decreases interaction with CBX5, abolishes localization to centromeres in interphase; when associated with A-169 and A-171."; /evidence="ECO:0000269|PubMed:21346195"; MUTAGEN 169; /note="V->A: Decreases interaction with CBX5, abolishes localization to centromeres in interphase; when associated with A-167 and A-171."; /evidence="ECO:0000269|PubMed:21346195"; MUTAGEN 169; /note="V->E: Abolishes interaction with CBX5."; /evidence="ECO:0000269|PubMed:20562864"; MUTAGEN 171; /note="I->A: Decreases interaction with CBX5, abolishes localization to centromeres in interphase; when associated with A-167 and A-169."; /evidence="ECO:0000269|PubMed:21346195"; MUTAGEN 171; /note="I->E: Abolishes interaction with CBX5 and AURKB."; /evidence="ECO:0000269|PubMed:20562864
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by AURKB or AURKC at its C-terminal part is important for AURKB or AURKC activation by INCENP. {ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:27332895}.
uniprot
proteins
protein_family
INCENP family
uniprot
proteins
pubmed
11139336
uniprot
proteins
pubmed
11453556
uniprot
proteins
pubmed
12925766
uniprot
proteins
pubmed
14610074
uniprot
proteins
pubmed
15249581
uniprot
proteins
pubmed
15316025
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16571674
uniprot
proteins
pubmed
16760428
uniprot
proteins
pubmed
16764853
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17956729
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20562864
uniprot
proteins
pubmed
21225229
uniprot
proteins
pubmed
21346195
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22920039
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27332895
uniprot
proteins
pubmed
9864353
uniprot
proteins
sequence_length
918
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11453556}. Chromosome, centromere {ECO:0000269|PubMed:11453556, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11453556, ECO:0000269|PubMed:15316025}. Midbody {ECO:0000269|PubMed:15316025}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14610074}. Note=Colocalized at synaptonemal complex central element from zygotene up to late pachytene when it begins to relocalize to heterochromatic chromocenters. Colocalizes with AURKB at a connecting strand traversing the centromere region and joining sister kinetochores, in metaphase II centromeres. This strand disappears at the metaphase II/anaphase II transition and relocalizes to the spindle midzone (By similarity). Colocalizes with AURKB at mitotic chromosomes (PubMed:11453556). Localizes to inner kinetochore (PubMed:16760428). Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis (PubMed:15316025). Cocalizes to the equatorial cell cortex at anaphase (PubMed:11453556). {ECO:0000250|UniProtKB:Q9WU62, ECO:0000269|PubMed:11453556, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428}.
uniprot
proteins