PIK3CB
entrez
5291
canonical
uniprot
P42338
canonical
ensembl
ENSG00000051382
resolver
ensp
ENSP00000417869
resolver
ensp
ENSP00000418143
resolver
ensp
ENSP00000501150
resolver
ensp
ENSP00000564598
resolver
ensp
ENSP00000564602
resolver
ensp
ENSP00000564605
resolver
ensp
ENSP00000608822
resolver
ensp
ENSP00000608825
resolver
ensp
ENSP00000608827
resolver
ensp
ENSP00000608828
resolver
ensp
ENSP00000625083
resolver
ensp
ENSP00000625084
resolver
ensp
ENSP00000625087
resolver
ensp
ENSP00000625089
resolver
ensp
ENSP00000718791
resolver
enst
ENST00000477593
resolver
enst
ENST00000674063
resolver
enst
ENST00000894539
resolver
enst
ENST00000894543
resolver
enst
ENST00000894546
resolver
enst
ENST00000938763
resolver
enst
ENST00000938766
resolver
enst
ENST00000938769
resolver
enst
ENST00000955024
resolver
enst
ENST00000955025
resolver
enst
ENST00000955028
resolver
enst
ENST00000955030
resolver
genesymbol
PIK3CB
resolver
genesymbol_syn
PIK3C1
resolver
hgnc
HGNC:8976
resolver
uniprot
B4DER4
resolver
uniprot
D3DNF0
resolver
uniprot
Q24JU2
resolver
uniprot_entry
B4DER4_HUMAN
resolver
uniprot_entry
PK3CB_HUMAN
resolver
uniprot_sec
D3DNF0
resolver
uniprot_sec
Q24JU2
resolver
amino_acid_sequence
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
uniprot
proteins
ec_number
2.7.1.153
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G protein-coupled receptor (GPCR) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Also has a protein kinase activity showing autophosphorylation (PubMed:12502714). {ECO:0000269|PubMed:12502714, ECO:0000269|PubMed:15135396, ECO:0000269|PubMed:18594509, ECO:0000269|PubMed:18755892, ECO:0000269|PubMed:21030680, ECO:0000269|PubMed:21383062}.
uniprot
proteins
mass_dalton
122762
uniprot
proteins
mutagenesis
MUTAGEN 342; /note="K->N: Enhanced inhibition by PIK3R1 leading to reduced lipid kinase activity and reduced oncogenicity. Does not modify regulation by GPCRs."; /evidence="ECO:0000269|PubMed:21030680"; MUTAGEN 805; /note="K->R: Loss of lipid kinase activity. May not affect insulin signaling and cell proliferation. Partially affects oncogene-induced transformation."; /evidence="ECO:0000269|PubMed:18594509"; MUTAGEN 1070; /note="S->A: Loss of autophosphorylation. No effect on phosphatidylinositol-4,5-bisphosphate 3-kinase activity."; /evidence="ECO:0000269|PubMed:12502714"; MUTAGEN 1070; /note="S->D,E: Loss of autophosphorylation. Decreased basal and stimulated phosphatidylinositol-4,5-bisphosphate 3-kinase activity."; /evidence="ECO:0000269|PubMed:12502714
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis. {ECO:0000305|PubMed:15135396}.
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation at Ser-1070 negatively regulates the phosphatidylinositol-4,5-bisphosphate 3-kinase activity. {ECO:0000269|PubMed:12502714}.
uniprot
proteins
protein_family
PI3/PI4-kinase family
uniprot
proteins
pubmed
11016459
uniprot
proteins
pubmed
12502714
uniprot
proteins
pubmed
15135396
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18594509
uniprot
proteins
pubmed
18755892
uniprot
proteins
pubmed
19635806
uniprot
proteins
pubmed
21030680
uniprot
proteins
pubmed
21035500
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21321382
uniprot
proteins
pubmed
21383062
uniprot
proteins
pubmed
32606397
uniprot
proteins
pubmed
8246984
uniprot
proteins
sequence_length
1070
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21383062, ECO:0000269|PubMed:32606397}. Nucleus {ECO:0000269|PubMed:21383062}. Note=Interaction with PIK3R2 is required for nuclear localization and export.
uniprot
proteins