GRK4
entrez
2868
canonical
uniprot
P32298
canonical
ensembl
ENSG00000125388
resolver
ensp
ENSP00000264764
resolver
ensp
ENSP00000381128
resolver
ensp
ENSP00000381129
resolver
ensp
ENSP00000427445
resolver
ensp
ENSP00000637963
resolver
genesymbol
GRK4
resolver
genesymbol_syn
GPRK2L
resolver
genesymbol_syn
GPRK4
resolver
hgnc
HGNC:4543
resolver
uniprot
O00641
resolver
uniprot
O00642
resolver
uniprot
Q13293
resolver
uniprot
Q13294
resolver
uniprot
Q13295
resolver
uniprot
Q14453
resolver
uniprot
Q14725
resolver
uniprot
Q15313
resolver
uniprot
Q15314
resolver
uniprot
Q15315
resolver
uniprot
Q15316
resolver
uniprot
Q17RH6
resolver
uniprot
Q53EQ8
resolver
uniprot_entry
GRK4_HUMAN
resolver
uniprot_sec
O00641
resolver
uniprot_sec
O00642
resolver
uniprot_sec
Q13293
resolver
uniprot_sec
Q13294
resolver
uniprot_sec
Q13295
resolver
uniprot_sec
Q14453
resolver
uniprot_sec
Q14725
resolver
uniprot_sec
Q15313
resolver
uniprot_sec
Q15314
resolver
uniprot_sec
Q15315
resolver
uniprot_sec
Q15316
resolver
uniprot_sec
Q17RH6
resolver
uniprot_sec
Q53EQ8
resolver
activity_regulation
ACTIVITY REGULATION: Autophosphorylation at Ser-485 activates the protein kinase activity (PubMed:26134571). Inhibited by heparin (PubMed:19520868). {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:26134571}.
uniprot
proteins
amino_acid_sequence
MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC
uniprot
proteins
ec_number
2.7.11.16
uniprot
proteins
function
FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors, such as ADRB2, DRD1 and DRD3 (PubMed:16338988, PubMed:19520868). Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:16338988, PubMed:19520868). Mediates phosphorylation of DRD1 in the absence of dopamine activation, resulting in constitutive desensitization (PubMed:16338988). {ECO:0000269|PubMed:16338988, ECO:0000269|PubMed:19520868}.; FUNCTION: [Isoform 1]: Phosphorylates rhodopsin and its activity is inhibited by calmodulin. {ECO:0000269|PubMed:8626439}.; FUNCTION: [Isoform 2]: In contrast to isoform 1, does not phosphorylate rhodopsin and does not interact with calmodulin. {ECO:0000269|PubMed:8626439}.; FUNCTION: [Isoform 3]: In contrast to isoform 1, does not phosphorylate rhodopsin and does not interact with calmodulin. {ECO:0000269|PubMed:8626439}.; FUNCTION: [Isoform 4]: In contrast to isoform 1, does not phosphorylate rhodopsin and does not interact with calmodulin. {ECO:0000269|PubMed:8626439}.
uniprot
proteins
mass_dalton
66583
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated at Ser-485 activates the protein kinase activity. {ECO:0000269|PubMed:26134571}.; PTM: Palmitoylated. {ECO:0000269|PubMed:8626439}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
GPRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
1338872
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16338988
uniprot
proteins
pubmed
16636192
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
19520868
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
26134571
uniprot
proteins
pubmed
8135832
uniprot
proteins
pubmed
8626439
uniprot
proteins
pubmed
9092566
uniprot
proteins
sequence_length
578
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8626439}. Cytoplasm, cell cortex {ECO:0000269|PubMed:8626439}. Note=Both at the cell surface and dispersed in the cytoplasm under basal conditions (PubMed:8626439). Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes (PubMed:19520868). DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells (PubMed:19520868). {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}.
uniprot
proteins