Plekho1
entrez
310674
canonical
uniprot
Q5BJM5
canonical
ensembl
ENSRNOG00000021170
resolver
ensp
ENSRNOP00000075725
resolver
ensp
ENSRNOP00000108174
resolver
enst
ENSRNOT00000079621
resolver
genesymbol
Plekho1
resolver
uniprot
A0A0G2KBB3
resolver
uniprot_entry
A0A0G2KBB3_RAT
resolver
uniprot_entry
PKHO1_RAT
resolver
amino_acid_sequence
MKKSGSGKRGPPDGNHQSVAPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYVSEKEVKDEKNSQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLARCRQPGTTAPNLIFLAVSPEEKESWINALSSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPASCAESFRVDLDKSVAQLAGSRRRADSDRIRPSSHRASSLSRPWERPDKGAPYTPQALKKLPSTEKSRCASLEEILSQRDTAPAHPLHLQAEESPAPVPSQPGQLSRIQDLVARKLEKTQELLAEVQGLGDGKWKAKDPPRSPPDSQSEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTSQHSQYRKSLM
uniprot
proteins
function
FUNCTION: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
46068
uniprot
proteins
post_translational_modification
PTM: C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641100
uniprot
proteins
sequence_length
408
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q53GL0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q53GL0}. Nucleus {ECO:0000250|UniProtKB:Q53GL0}. Cytoplasm {ECO:0000250|UniProtKB:Q53GL0}. Note=Predominantly localized to the plasma membrane through the binding to phosphatidylinositol 3-phosphate. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells. {ECO:0000250|UniProtKB:Q53GL0}.
uniprot
proteins