Acmsd
entrez
266645
canonical
uniprot
Q8R519
canonical
ensembl
ENSMUSG00000026348
resolver
ensp
ENSMUSP00000048482
resolver
enst
ENSMUST00000038006
resolver
genesymbol
Acmsd
resolver
uniprot
B9EI97
resolver
uniprot
Q3UNW3
resolver
uniprot_entry
ACMSD_MOUSE
resolver
uniprot_sec
B9EI97
resolver
uniprot_sec
Q3UNW3
resolver
activity_regulation
ACTIVITY REGULATION: Competitively inhibited by pyridine-2,6-dicarboxylic acid (PDC), a cyclic substrate analog. Oligomerization increases activity. {ECO:0000250|UniProtKB:Q8TDX5}.
uniprot
proteins
amino_acid_sequence
MKIDIHTHILPKEWPDLEKRFGYGGWVQLQQQGKGEAKMIKDGKLFRVIQQNCWDPEVRIREMNQKGVTVQALSTVPVMFSYWAKPKDTLELCQFLNNDLAATVARYPRRFVGLGTLPMQAPELAVEEMERCVKALGFPGIQIGSHINTWDLNDPELFPIYAAAERLNCSLFVHPWDMQMDGRMAKYWLPWLVGMPSETTMAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTIGRIAHGFNMRPDLCAQDNPSDPRKYLGSFYTDSLVHDPLSLKLLTDVIGKDKVMLGTDYPFPLGEQEPGKLIESMAEFDEETKDKLTAGNALAFLGLERKLFE
uniprot
proteins
ec_number
4.1.1.45
uniprot
proteins
function
FUNCTION: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolinate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. {ECO:0000250|UniProtKB:Q8TDX5}.
uniprot
proteins
mass_dalton
38027
uniprot
proteins
protein_family
ACMSD family
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
pubmed
12140278
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
336
uniprot
proteins