NANOG
entrez
79923
canonical
uniprot
Q9H9S0
canonical
ensembl
ENSG00000111704
resolver
ensp
ENSP00000229307
resolver
ensp
ENSP00000435288
resolver
genesymbol
NANOG
resolver
hgnc
HGNC:20857
resolver
uniprot
A8K4D1
resolver
uniprot
D3DUU4
resolver
uniprot
Q2TTG0
resolver
uniprot
Q6JZS5
resolver
uniprot_entry
A8K4D1_HUMAN
resolver
uniprot_entry
NANOG_HUMAN
resolver
uniprot_sec
D3DUU4
resolver
uniprot_sec
Q2TTG0
resolver
uniprot_sec
Q6JZS5
resolver
amino_acid_sequence
MSVDPACPQSLPCFEASDCKESSPMPVICGPEENYPSLQMSSAEMPHTETVSPLPSSMDLLIQDSPDSSTSPKGKQPTSAEKSVAKKEDKVPVKKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQELSNILNLSYKQVKTWFQNQRMKSKRWQKNNWPKNSNGVTQKASAPTYPSLYSSYHQGCLVNPTGNLPMWSNQTWNNSTWSNQTQNIQSWSNHSWNTQTWCTQSWNNQAWNSPFYNCGEESLQSCMQFQPNSPASDLEAALEAAGEGLNVIQQTTRYFSTPQTMDLFLNYSMNMQPEDV
uniprot
proteins
function
FUNCTION: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. {ECO:0000269|PubMed:15983365, ECO:0000269|PubMed:16000880, ECO:0000269|PubMed:16391521, ECO:0000269|PubMed:25825768}.
uniprot
proteins
mass_dalton
34620
uniprot
proteins
mutagenesis
MUTAGEN 102; /note="F->A: No effect on POU5F1 promoter DNA-binding."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 122; /note="L->A: Increased POU5F1 promoter DNA-binding and protein stability."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 124; /note="Q->A: Decreased POU5F1 promoter DNA-binding and protein stability."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 125; /note="M->A: Decreased POU5F1 promoter DNA-binding and protein stability."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 136; /note="Y->A: Decreased POU5F1 promoter DNA-binding and protein stability."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 137; /note="K->A: Inhibits POU5F1 promoter DNA-binding."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 140; /note="K->A: Decreased POU5F1 promoter DNA-binding and protein stability."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 141; /note="T->A: Inhibits POU5F1 promoter DNA-binding."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 144; /note="Q->A: No effect on POU5F1 promoter DNA-binding. Decreased protein stability."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 145; /note="N->A: Inhibits POU5F1 promoter DNA-binding."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 147; /note="R->A: Inhibits POU5F1 promoter DNA-binding."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 148; /note="M->A: No effect on POU5F1 promoter DNA-binding. Increased protein stability."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 151; /note="K->A: Decreased POU5F1 promoter DNA-binding and protein stability."; /evidence="ECO:0000269|PubMed:25825768
uniprot
proteins
protein_family
Nanog homeobox family
uniprot
proteins
pubmed
12787504
uniprot
proteins
pubmed
12787505
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14990856
uniprot
proteins
pubmed
15108323
uniprot
proteins
pubmed
15233988
uniprot
proteins
pubmed
15582778
uniprot
proteins
pubmed
15982323
uniprot
proteins
pubmed
15983365
uniprot
proteins
pubmed
16000880
uniprot
proteins
pubmed
16391521
uniprot
proteins
pubmed
25825768
uniprot
proteins
pubmed
26687479
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15983365}.
uniprot
proteins