Kdm5c
entrez
20591
canonical
uniprot
P41230
canonical
ensembl
ENSMUSG00000025332
resolver
ensp
ENSMUSP00000080814
resolver
ensp
ENSMUSP00000108203
resolver
ensp
ENSMUSP00000108207
resolver
ensp
ENSMUSP00000331526
resolver
genesymbol
Kdm5c
resolver
genesymbol_syn
Jarid1c
resolver
genesymbol_syn
Kiaa0234
resolver
genesymbol_syn
Smcx
resolver
genesymbol_syn
Xe169
resolver
uniprot
O54995
resolver
uniprot
Q3TYU8
resolver
uniprot
Q3U1X6
resolver
uniprot
Q3U282
resolver
uniprot
Q6ZQF8
resolver
uniprot
Q80XQ9
resolver
uniprot
Q9CVI4
resolver
uniprot
Q9D0C3
resolver
uniprot
Q9QVR8
resolver
uniprot
Q9R039
resolver
uniprot_entry
KDM5C_MOUSE
resolver
uniprot_sec
O54995
resolver
uniprot_sec
Q3TYU8
resolver
uniprot_sec
Q3U1X6
resolver
uniprot_sec
Q3U282
resolver
uniprot_sec
Q6ZQF8
resolver
uniprot_sec
Q80XQ9
resolver
uniprot_sec
Q9CVI4
resolver
uniprot_sec
Q9D0C3
resolver
uniprot_sec
Q9QVR8
resolver
uniprot_sec
Q9R039
resolver
amino_acid_sequence
MELGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGGYETICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRPFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKMESTSPKTFLEGKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQRLKNCLSEAEACVSRALGLVSGQEAGPDRVAGLQMTLAELRDFLGQMNNLPCAMHQIGDVKGILEQVEAYQTEAREALVSQPSSPGLLQSLLERGQQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAIMRGLLVAGASVAPSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAIIHEAENIPVHLPNIQSLKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLALLTTASSTASICVCGQVPAGVGALQCDLCQDWFHGRCVTVPRLLSSQRSSLPSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQVLASEEVTALLGRLAELRQRLQAESKPEESLAYPSDGGEGTGNMPKVQGLLENGDSVTSPEKVATEEGSGKRDLELLSSILPQLSGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLKRVQTLLELEKAERHGSRTRGRALERRRRRKVDRGGEPDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEVPPVPFPNSGSPSIQEDQDGLEPVLEAGSDTSAPFSTLTSRLLMSCPQQPSLQQL
uniprot
proteins
ec_number
1.14.11.67
uniprot
proteins
function
FUNCTION: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements (By similarity). Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. {ECO:0000250|UniProtKB:P41229, ECO:0000269|PubMed:21960634}.
uniprot
proteins
mass_dalton
175313
uniprot
proteins
protein_family
JARID1 histone demethylase family
uniprot
proteins
pubmed
10441747
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21960634
uniprot
proteins
pubmed
7544442
uniprot
proteins
pubmed
7951230
uniprot
proteins
pubmed
7951318
uniprot
proteins
pubmed
9723615
uniprot
proteins
sequence_length
1554
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537}.
uniprot
proteins