ITSN1
entrez
6453
canonical
uniprot
Q15811
canonical
ensembl
ENSG00000205726
resolver
ensp
ENSP00000370691
resolver
ensp
ENSP00000370719
resolver
ensp
ENSP00000382275
resolver
ensp
ENSP00000382286
resolver
ensp
ENSP00000382289
resolver
ensp
ENSP00000382290
resolver
ensp
ENSP00000382292
resolver
ensp
ENSP00000382301
resolver
ensp
ENSP00000710166
resolver
enst
ENST00000399355
resolver
genesymbol
ITSN1
resolver
genesymbol_syn
ITSN
resolver
genesymbol_syn
SH3D1A
resolver
hgnc
HGNC:6183
resolver
uniprot
A7XZY7
resolver
uniprot
A7Y322
resolver
uniprot
A8CTX8
resolver
uniprot
A8CTY3
resolver
uniprot
A8CTY7
resolver
uniprot
A8D7D0
resolver
uniprot
A8DCP3
resolver
uniprot
B4DTM2
resolver
uniprot
E7ERJ1
resolver
uniprot
E9PE44
resolver
uniprot
E9PG01
resolver
uniprot
E9PHV2
resolver
uniprot
F8W7U0
resolver
uniprot
O95216
resolver
uniprot
Q0PW94
resolver
uniprot
Q0PW95
resolver
uniprot
Q0PW97
resolver
uniprot
Q14BD3
resolver
uniprot
Q1ED40
resolver
uniprot
Q20BK3
resolver
uniprot
Q6PD56
resolver
uniprot
Q9UET5
resolver
uniprot
Q9UK60
resolver
uniprot
Q9UNK1
resolver
uniprot
Q9UNK2
resolver
uniprot
Q9UQ92
resolver
uniprot_entry
A7XZY7_HUMAN
resolver
uniprot_entry
F8W7U0_HUMAN
resolver
uniprot_entry
ITSN1_HUMAN
resolver
uniprot_entry
Q6PD56_HUMAN
resolver
uniprot_sec
A7Y322
resolver
uniprot_sec
A8CTX8
resolver
uniprot_sec
A8CTY3
resolver
uniprot_sec
A8CTY7
resolver
uniprot_sec
A8D7D0
resolver
uniprot_sec
A8DCP3
resolver
uniprot_sec
B4DTM2
resolver
uniprot_sec
E7ERJ1
resolver
uniprot_sec
E9PE44
resolver
uniprot_sec
E9PG01
resolver
uniprot_sec
E9PHV2
resolver
uniprot_sec
O95216
resolver
uniprot_sec
Q0PW94
resolver
uniprot_sec
Q0PW95
resolver
uniprot_sec
Q0PW97
resolver
uniprot_sec
Q14BD3
resolver
uniprot_sec
Q1ED40
resolver
uniprot_sec
Q20BK3
resolver
uniprot_sec
Q9UET5
resolver
uniprot_sec
Q9UK60
resolver
uniprot_sec
Q9UNK1
resolver
uniprot_sec
Q9UNK2
resolver
uniprot_sec
Q9UQ92
resolver
amino_acid_sequence
MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKPCRSHGKSNPYCEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEIRVADIKKDQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDEP
uniprot
proteins
function
FUNCTION: Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688). {ECO:0000250|UniProtKB:Q9WVE9, ECO:0000250|UniProtKB:Q9Z0R4, ECO:0000269|PubMed:11584276, ECO:0000269|PubMed:11744688, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:29887380}.; FUNCTION: [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. {ECO:0000250|UniProtKB:Q9Z0R4}.
uniprot
proteins
mass_dalton
195422
uniprot
proteins
mutagenesis
MUTAGEN 1078; /note="I->K,S: Abolishes interaction with FCHSD2."; /evidence="ECO:0000269|PubMed:29887380"; MUTAGEN 1119; /note="R->A,E: Abolishes interaction with FCHSD2."; /evidence="ECO:0000269|PubMed:29887380"; MUTAGEN 1369; /note="M->L: Decreases specificity for CDC42; when associated with I-1376."; /evidence="ECO:0000269|PubMed:12006984"; MUTAGEN 1376; /note="L->I: Decreases specificity for CDC42; when associated with L-1369."; /evidence="ECO:0000269|PubMed:12006984
uniprot
proteins
pubmed
10482960
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
11584276
uniprot
proteins
pubmed
11690630
uniprot
proteins
pubmed
11744688
uniprot
proteins
pubmed
12006984
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19718658
uniprot
proteins
pubmed
19777371
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20448150
uniprot
proteins
pubmed
20946875
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21712076
uniprot
proteins
pubmed
22484487
uniprot
proteins
pubmed
22648170
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27670116
uniprot
proteins
pubmed
29030480
uniprot
proteins
pubmed
29599122
uniprot
proteins
pubmed
29887380
uniprot
proteins
pubmed
32315611
uniprot
proteins
pubmed
9465890
uniprot
proteins
pubmed
9630982
uniprot
proteins
pubmed
9799604
uniprot
proteins
sequence_length
1721
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:11744688}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q9WVE9}. Cell projection, lamellipodium {ECO:0000269|PubMed:11744688}. Cell membrane {ECO:0000269|PubMed:11744688, ECO:0000269|PubMed:20946875}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:20946875, ECO:0000269|PubMed:29887380}. Recycling endosome {ECO:0000269|PubMed:29030480}. Endosome {ECO:0000250|UniProtKB:Q9Z0R4}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9Z0R4}. Note=Colocalizes with SGIP1 at the plasma membrane in structures corresponding most probably to clathrin-coated pits (PubMed:20946875). Colocalizes with RAB13 on cytoplasmic vesicles that are most likely recycling endosomes (PubMed:29030480). {ECO:0000269|PubMed:20946875, ECO:0000269|PubMed:29030480}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:29599122}. Endomembrane system {ECO:0000269|PubMed:21712076}. Nucleus envelope {ECO:0000269|PubMed:29599122}. Note=Shuttles between the cytoplasm and nucleus in an XPO1/CRM1-dependent manner. {ECO:0000269|PubMed:29599122}.; SUBCELLULAR LOCATION: [Isoform 5]: Endomembrane system {ECO:0000269|PubMed:21712076}.
uniprot
proteins