SLC5A10
entrez
125206
canonical
uniprot
A0PJK1
canonical
ensembl
ENSG00000154025
resolver
ensp
ENSP00000324346
resolver
ensp
ENSP00000379005
resolver
ensp
ENSP00000379007
resolver
ensp
ENSP00000379008
resolver
ensp
ENSP00000401875
resolver
genesymbol
SLC5A10
resolver
genesymbol_syn
SGLT5
resolver
hgnc
HGNC:23155
resolver
uniprot
A8MUC9
resolver
uniprot
B4DPI0
resolver
uniprot
B7WPR4
resolver
uniprot
Q6P5X0
resolver
uniprot
Q8IXM4
resolver
uniprot
Q96LQ1
resolver
uniprot_entry
SC5AA_HUMAN
resolver
uniprot_sec
A8MUC9
resolver
uniprot_sec
B4DPI0
resolver
uniprot_sec
B7WPR4
resolver
uniprot_sec
Q6P5X0
resolver
uniprot_sec
Q8IXM4
resolver
uniprot_sec
Q96LQ1
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform 1]: Inhibited by phlorizin. {ECO:0000269|PubMed:24573086}.
uniprot
proteins
amino_acid_sequence
MAANSTSDLHTPGTQLSVADIIVITVYFALNVAVGIWSSCRASRNTVNGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYISSEIVTLPEYIQKRYGGQRIRMYLSVLSLLLSVFTKISLDLYAGALFVHICLGWNFYLSTILTLGITALYTIAGGLAAVIYTDALQTLIMVVGAVILTIKAFDQIGGYGQLEAAYAQAIPSRTIANTTCHLPRTDAMHMFRDPHTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARDLNHAKAGSILASYLKMLPMGLIIMPGMISRALFPDDVGCVVPSECLRACGAEVGCSNIAYPKLVMELMPIGLRGLMIAVMLAALMSSLTSIFNSSSTLFTMDIWRRLRPRSGERELLLVGRLVIVALIGVSVAWIPVLQDSNSGQLFIYMQSVTSSLAPPVTAVFVLGVFWRRANEQGAFWGLIAGLVVGATRLVLEFLNPAPPCGEPDTRPAVLGSIHYLHFAVALFALSGAVVVAGSLLTPPPQSVQIENLTWWTLAQDVPLGTKAGDGQTPQKHAFWARVCGFNAILLMCVNIFFYAYFA
uniprot
proteins
function
FUNCTION: [Isoform 1]: Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2 (PubMed:22212718, PubMed:23451068, PubMed:24573086). Has likely evolved to enable renal reabsorption of D-mannose, an important constituent of oligosaccharide chains of glycoproteins. Contributes to dietary D-fructose reabsorption from glomerular filtrate across the brush border of the kidney (PubMed:22212718, PubMed:23451068). {ECO:0000269|PubMed:22212718, ECO:0000269|PubMed:23451068, ECO:0000269|PubMed:24573086}.; FUNCTION: [Isoform 2]: Appears to have no transporter activity. {ECO:0000269|PubMed:22212718}.
uniprot
proteins
mass_dalton
64342
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
22212718
uniprot
proteins
pubmed
23451068
uniprot
proteins
pubmed
24573086
uniprot
proteins
sequence_length
596
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q5SWY8}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 73..93; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 174..194; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 301..321; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 356..376; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 410..430; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 444..464; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 472..492; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 514..534; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 576..596; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins