Med1
entrez
19014
canonical
uniprot
Q925J9
canonical
ensembl
ENSMUSG00000018160
resolver
ensp
ENSMUSP00000018304
resolver
ensp
ENSMUSP00000090411
resolver
ensp
ENSMUSP00000103169
resolver
ensp
ENSMUSP00000171967
resolver
enst
ENSMUST00000092735
resolver
genesymbol
Med1
resolver
genesymbol_syn
Crsp210
resolver
genesymbol_syn
Drip205
resolver
genesymbol_syn
Pbp
resolver
genesymbol_syn
Pparbp
resolver
genesymbol_syn
Trap220
resolver
genesymbol_syn
Trip2
resolver
uniprot
A2A526
resolver
uniprot
A2A528
resolver
uniprot
B1AQH6
resolver
uniprot
O88323
resolver
uniprot
Q3UHV0
resolver
uniprot
Q6AXD5
resolver
uniprot
Q8BW37
resolver
uniprot
Q8BX19
resolver
uniprot
Q8VDQ7
resolver
uniprot
Q925K0
resolver
uniprot_entry
B1AQH6_MOUSE
resolver
uniprot_entry
MED1_MOUSE
resolver
uniprot_sec
A2A526
resolver
uniprot_sec
A2A528
resolver
uniprot_sec
O88323
resolver
uniprot_sec
Q3UHV0
resolver
uniprot_sec
Q6AXD5
resolver
uniprot_sec
Q8BW37
resolver
uniprot_sec
Q8BX19
resolver
uniprot_sec
Q8VDQ7
resolver
uniprot_sec
Q925K0
resolver
amino_acid_sequence
MKAQGETEDSERLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFEEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAAPLDKILHGSVGYLTPRSGGHLMNMKYYASPSDLLDDKTASPIILHEKNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPADNKWTPSFSAVTSANSVDLPACFFLKFPQPIPVSKAFVQKLQNCTGIPLFETPPTYLPLYELITQFELSKDPDPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGQSLQGTLVSKITFQHPGRVPLILNMIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKAKKKKSSRVPPDKPKHQTEDDFQRELFSMDVDSQNPMFDVSMTADALDTPHITPAPSQCSTPPATYPQPVSHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDSDVFQTNNNENPYTDPADLIADAAGSPNSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGMPMLGGDNGEPKFKGSSQADTVDFSIISVAGKALGAADLMEHHSGSQSPLLTTGELGKEKTQKRVKEGNGTGASSGSGPGSDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSLASASTSGKVKSSKSEGSSSSKLSGSMYASQGSSGSSQSKNSSQTGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSISKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSSGSHVSGTSSSSGMKSSSGSASSGSVSQKTPPASNSCTPSSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPIDSQMGASTNSSNHPMSSKHNTSGGEFQSKREKSDKDKSKVSASGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESGGDGLRPQIASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNVDSESESGSSIAERSYQNSPSSEDGIRPLPEYSTEKHKKHKKEKKKVRDKDRDKKKSHSMKPENWSKSPISSDPTASVTNNPILSADRPSRLSPDFMIGEEDDDLMDVALIGN
uniprot
proteins
function
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Essential for embryogenesis, including development of the central nervous system, heart, liver and placenta and for erythropoiesis. Also required for normal transcriptional control of thyroid-stimulating hormone beta (TSHB) in the pituitary. Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (By similarity). {ECO:0000250|UniProtKB:Q15648, ECO:0000269|PubMed:10882104, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:14500757, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15150259, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:16137621, ECO:0000269|PubMed:17132730, ECO:0000269|PubMed:9325263}.
uniprot
proteins
mass_dalton
167141
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the nucleolus (By similarity). Phosphorylation increases its interaction with PSIP1 (By similarity). {ECO:0000250|UniProtKB:Q15648}.
uniprot
proteins
protein_family
Mediator complex subunit 1 family
uniprot
proteins
pubmed
10882104
uniprot
proteins
pubmed
11266503
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
11867769
uniprot
proteins
pubmed
12037571
uniprot
proteins
pubmed
12709428
uniprot
proteins
pubmed
14500757
uniprot
proteins
pubmed
14636573
uniprot
proteins
pubmed
15150259
uniprot
proteins
pubmed
15340084
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15528208
uniprot
proteins
pubmed
16137621
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17132730
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24043798
uniprot
proteins
pubmed
25644604
uniprot
proteins
pubmed
25644605
uniprot
proteins
pubmed
32069354
uniprot
proteins
pubmed
9325263
uniprot
proteins
sequence_length
1575
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15150259}. Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3. {ECO:0000250}.
uniprot
proteins