Ncaph
entrez
215387
canonical
uniprot
Q8C156
canonical
ensembl
ENSMUSG00000034906
resolver
ensp
ENSMUSP00000106017
resolver
enst
ENSMUST00000110387
resolver
genesymbol
Ncaph
resolver
genesymbol_syn
Brrn
resolver
genesymbol_syn
Brrn1
resolver
genesymbol_syn
Caph
resolver
uniprot
Q8BY01
resolver
uniprot
Q8VDM9
resolver
uniprot_entry
CND2_MOUSE
resolver
uniprot_sec
Q8BY01
resolver
uniprot_sec
Q8VDM9
resolver
amino_acid_sequence
MRIPRSETMNSSFLKARGQQDVLSSPLERVPPASRPGKAPLGTPKTPVLEDFPQNDDEKERMQRRRSRVFDLQFSTDSIHLASPNRNIDVSTTISKFTNTQITEHYSTCIKLSSENKITTKNAFGLHLIDFMSEILKQKDAEPTNFKVAAGTLDASTKIYAVRVDAVHADVYRVLGGLGKDTPPQGEESHSGDGSTLETERTKKPAKPKKKQSCKTIEQNLSNINVSEADGKCAVDPMFQKTAASFDECSTTGVFLSTLHCQDYRSELLFPSDMQTLSSGEPLELPDLGFVDMTDLEASLQQCVEDRPLCPSLAGFQFTKWDSETHNESVSALVDKFKKNDQVFDINAEAEDDEEDVPDGPLVEDFVDNDEPDLSAAGDHEEFRSWKELCQVQSNQEEVISLEDRDIQVMCSFLSMKPGEYSYFSPRTMKMWAGPDHWRFRPRPKQDATSCTEHKKKSAKKDFEINFDDDIDFDAYFQKTKAATILTKSTLENQNWKATTLPTDFHYETDNLIQLHLKPGKRSLKMDQDQKAKTEHYEEIEDYDYNNPNDTSNYCPGLQAADSDYEEADDLFADPVGTLDLESDPKTTQENGHISPENQGVDITTYQELNLVAEPQKVNKIEIHYAKTAKKMDMKKLKQSMWSLLTKFSRKEADTEANHTESGQEGAPEEVADEKKLSGLTKDLQTRLPPLMAQNLSIPLAFACLLHLANEKNLKLEGTEDLSDVLVMQGD
uniprot
proteins
function
FUNCTION: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size. {ECO:0000250|UniProtKB:Q15003}.
uniprot
proteins
mass_dalton
82303
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
CND2 (condensin subunit 2) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
731
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Chromosome {ECO:0000250}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase (By similarity). {ECO:0000250}.
uniprot
proteins