Aifm1
entrez
83533
canonical
uniprot
Q9JM53
canonical
ensembl
ENSRNOG00000006067
resolver
ensembl
ENSRNOG00055015107
resolver
ensembl
ENSRNOG00060018802
resolver
ensembl
ENSRNOG00065011395
resolver
ensp
ENSRNOP00000008503
resolver
ensp
ENSRNOP00000074241
resolver
ensp
ENSRNOP00055021081
resolver
ensp
ENSRNOP00060026473
resolver
ensp
ENSRNOP00065014149
resolver
enst
ENSRNOT00000008503
resolver
enst
ENSRNOT00000084848
resolver
enst
ENSRNOT00055025853
resolver
enst
ENSRNOT00060032463
resolver
enst
ENSRNOT00065018509
resolver
genesymbol
Aifm1
resolver
genesymbol_syn
Aif
resolver
genesymbol_syn
Pdcd8
resolver
uniprot
A0A0G2K7K2
resolver
uniprot
Q548E3
resolver
uniprot_entry
A0A0G2K7K2_RAT
resolver
uniprot_entry
AIFM1_RAT
resolver
uniprot_sec
Q548E3
resolver
amino_acid_sequence
MFRCGGLAGAFKQKLVPLVRSVCVQRPKQRNRLPGNLFQQWRVPLELQMARQMASSGPSGGKMDNSVLVLIVGLSTIGAGAYAYKTIKEDQKRYNERIMGLGLSPEEKQRRAIASAAEGGSVPPIRVPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLQFRQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRALEKISREVKSITVIGGGFLGSELACALGRKSQASGIEVIQLFPEKGNMGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGKLLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIPPSDPAVPQVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED
uniprot
proteins
ec_number
1.6.99.-
uniprot
proteins
function
FUNCTION: Functions both as NADH oxidoreductase and as regulator of apoptosis (By similarity). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Binds to DNA in a sequence-independent manner (By similarity). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (By similarity). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (By similarity). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (By similarity). {ECO:0000250|UniProtKB:O95831, ECO:0000250|UniProtKB:Q9Z0X1}.
uniprot
proteins
mass_dalton
66723
uniprot
proteins
post_translational_modification
PTM: Under normal conditions, a 54-residue N-terminal segment is first proteolytically removed during or just after translocation into the mitochondrial intermembrane space (IMS) by the mitochondrial processing peptidase (MPP) to form the inner-membrane-anchored mature form (AIFmit). During apoptosis, it is further proteolytically processed at amino-acid position 101 leading to the generation of the mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis in a caspase-independent manner. {ECO:0000250|UniProtKB:O95831}.; PTM: Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation. Ubiquitination at Lys-254 by XIAP/BIRC4 blocks its ability to bind DNA and induce chromatin degradation, thereby inhibiting its ability to induce cell death. {ECO:0000250|UniProtKB:O95831}.
uniprot
proteins
protein_family
FAD-dependent oxidoreductase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
612
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q9Z0X1}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9Z0X1}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z0X1}. Nucleus {ECO:0000250|UniProtKB:Q9Z0X1}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O95831}. Note=Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit) (By similarity). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol) (By similarity). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). Translocation into the nucleus is promoted by interaction with (auto-poly-ADP-ribosylated) processed form of PARP1 (By similarity). Colocalizes with EIF3G in the nucleus and perinuclear region (By similarity). {ECO:0000250|UniProtKB:O95831, ECO:0000250|UniProtKB:Q9Z0X1}.
uniprot
proteins