MYLIP
entrez
29116
canonical
uniprot
Q8WY64
canonical
ensembl
ENSG00000007944
resolver
ensp
ENSP00000349298
resolver
ensp
ENSP00000520754
resolver
ensp
ENSP00000520755
resolver
enst
ENST00000718320
resolver
enst
ENST00000718321
resolver
genesymbol
MYLIP
resolver
genesymbol_syn
BZF1
resolver
genesymbol_syn
IDOL
resolver
hgnc
HGNC:21155
resolver
uniprot
A0ABB0MVD9
resolver
uniprot
A0ABB0MVE0
resolver
uniprot
Q5TIA4
resolver
uniprot
Q9BU73
resolver
uniprot
Q9NRL9
resolver
uniprot
Q9UHE7
resolver
uniprot_entry
A0ABB0MVD9_HUMAN
resolver
uniprot_entry
A0ABB0MVE0_HUMAN
resolver
uniprot_entry
MYLIP_HUMAN
resolver
uniprot_sec
Q5TIA4
resolver
uniprot_sec
Q9BU73
resolver
uniprot_sec
Q9NRL9
resolver
uniprot_sec
Q9UHE7
resolver
activity_regulation
ACTIVITY REGULATION: Can bind 1 iron ion per dimer. Iron binding seems to decrease LDLR degradation activity. {ECO:0000269|PubMed:21685362}.
uniprot
proteins
amino_acid_sequence
MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFGDYNQNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRNNQSPSHSPLKSSESSMNCSSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. {ECO:0000269|PubMed:10593918, ECO:0000269|PubMed:12826659, ECO:0000269|PubMed:14550572, ECO:0000269|PubMed:19520913, ECO:0000269|PubMed:20427281, ECO:0000269|PubMed:22109552}.
uniprot
proteins
mass_dalton
49910
uniprot
proteins
mutagenesis
MUTAGEN 265; /note="Y->A: Unable to clear LDLR from the plasma membrane."; /evidence="ECO:0000269|PubMed:22109552"; MUTAGEN 269; /note="T->R: Unable to clear LDLR from the plasma membrane."; /evidence="ECO:0000269|PubMed:22109552"; MUTAGEN 387; /note="C->A: Abolishes autoubiquitination."; /evidence="ECO:0000269|PubMed:14550572, ECO:0000269|PubMed:19520913, ECO:0000269|PubMed:21685362"; MUTAGEN 387; /note="C->A: Abolishes ubiquitin ligase activity."; /evidence="ECO:0000269|PubMed:14550572, ECO:0000269|PubMed:19520913, ECO:0000269|PubMed:21685362"; MUTAGEN 389; /note="V->R: Inhibits LDLR degradation."; /evidence="ECO:0000269|PubMed:21685362"; MUTAGEN 415; /note="L->E: Inhibits LDLR degradation."; /evidence="ECO:0000269|PubMed:21685362
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000269|PubMed:14550572, ECO:0000269|PubMed:22109552}.
uniprot
proteins
pubmed
10593918
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
12826659
uniprot
proteins
pubmed
14550572
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
19520913
uniprot
proteins
pubmed
20427281
uniprot
proteins
pubmed
21685362
uniprot
proteins
pubmed
22109552
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:14550572}. Cell membrane {ECO:0000269|PubMed:14550572}; Peripheral membrane protein {ECO:0000269|PubMed:14550572}.
uniprot
proteins