Rnf10
entrez
288710
canonical
uniprot
Q5XI59
canonical
ensembl
ENSRNOG00000001172
resolver
ensp
ENSRNOP00000063855
resolver
ensp
ENSRNOP00000106011
resolver
enst
ENSRNOT00000064910
resolver
genesymbol
Rnf10
resolver
uniprot
A0A0H2UI24
resolver
uniprot_entry
A0A0H2UI24_RAT
resolver
uniprot_entry
RNF10_RAT
resolver
amino_acid_sequence
MPQSSPSTAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSNGSKRYNRKREPSYPKNENFSNQSRRSNSQKSKTFNKTPPQRGGGSSKPFSSSSNGGRRDEVAEAQRAEFSPAQFSGPKKINLNHLLNFTFEPRGQAGHFEGSGHGSWGKRNKWGHKPFNKELFLQANCQFVVSEDQDYTANFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSERTWSKCPICYSSVHKKDLKSVVATESRQYVVGDTITMQLMKREKGVLVALPKSKWMNVDHPISLGDEQHSQYSKLLLASKEQVLHRVVLEEKVALEQQLAEEKHTPESCFIEAALQEVKIREEALSGVAGGRAEVTGVVTALEQLVLMAPLAKESAFQPRKGVLEYLSAFDEEAAQVCSLDPPGPLALPLVEEEEAVSEPEACEDLIADDSLGEGTVCAELSQEEPIAKPGFTQLSSSPCYYFYQAEDGQHMFLHPVNVRCLVREYGSLEQSPEKISATVVEIAGYSMSEDVRQRHRYLSHLPLTCEFSICELALQPPVVSKETLEMFSDDIEKRKRQRQKKAREERRRERRIELEENKRQGRYPEVHIPLENLQQFPAFNSYTCSSDSALGPTSTEGHGALSLSPLSRSPGSHADFLLTPLSPTASQGSPSFCVGSLEEDSPFLSFAQMLRVGKAKADGWPKAAPKKDDNSLAPPAPVDSDGESDNSDRVPVPSFQNSFSQAIEAAFMKLDTPATSDPLSDRGGRKRKRQKQKLLFSTSVVHTK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (By similarity). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC) or elongation (By similarity). The ribosome quality control is activated in response to ribosome subunit imbalance, amino acid starvation or downstream the EIF2AK4/GCN2-mediated integrated stress response (ISR) (By similarity). RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3: monoubiquitinated RPS2/us5 and RPS3/us3 are then recognized by RIOK3 kinase, leading to 18S non-functional rRNA decay and degradation of the 40S ribosomal subunit (By similarity). The action of RNF10 in iRQC is counteracted by USP10 (By similarity). May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (PubMed:18941509). Acts as a regulator of Schwann cell differentiation and myelination (PubMed:18941509). {ECO:0000250|UniProtKB:Q8N5U6, ECO:0000269|PubMed:18941509}.
uniprot
proteins
mass_dalton
88410
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8N5U6}.
uniprot
proteins
protein_family
RNF10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18941509
uniprot
proteins
sequence_length
802
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8N5U6}. Nucleus {ECO:0000269|PubMed:18941509}.
uniprot
proteins