Gje1
entrez
76743
canonical
uniprot
Q9CX92
canonical
ensembl
ENSMUSG00000019867
resolver
ensp
ENSMUSP00000020016
resolver
enst
ENSMUST00000020016
resolver
genesymbol
Gje1
resolver
genesymbol_syn
Cx23
resolver
genesymbol_syn
Gjf1
resolver
uniprot_entry
CXE1_MOUSE
resolver
amino_acid_sequence
MSLNYIKNFYEGCVKPPTVIGQFHTLFFGSVRMFFLGVLGFAVYGNEALHFSCDPDKREINLFCYNQFRPITPQVFWALQLVIVLLPGAIFHLYAACKSINQDCILQKPVYTVIYVLSVLLRISLEVFAFWLQIHLFGFQVKPIYLCDTESLGKKPNILKCMVPEHFEKTIFLIAMYTFTVITMVLCVAEVFEIIFRRSCFLFKR
uniprot
proteins
function
FUNCTION: Mediates calcium-independent ATP release, suggesting activity as a hemichannel (PubMed:18849090). Does not form functional gap junctions (PubMed:18849090). May play a non-essential role in eye lens development (PubMed:18385072, PubMed:27038752). {ECO:0000269|PubMed:18385072, ECO:0000269|PubMed:27038752}.
uniprot
proteins
mass_dalton
23831
uniprot
proteins
mutagenesis
MUTAGEN 32; /note="R->Q: In Aey12; dominant negative mutation. Viable and fertile with a small eye phenotype. The lens is absent and only the lens envelope remains. The retina is misfolded and poorly differentiated. Heterozygotes show variable degrees of lens opacity and abnormal primary lens fiber elongation. Defects are apparent from embryonic stage 12.5 dpc onwards."; /evidence="ECO:0000269|PubMed:18385072
uniprot
proteins
protein_family
Beta-type (group I) subfamily
uniprot
proteins
protein_family
Connexin family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18385072
uniprot
proteins
pubmed
18849090
uniprot
proteins
pubmed
27038752
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18849090}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 75..95; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 171..191; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins