CABLES1
entrez
91768
canonical
uniprot
Q8TDN4
canonical
ensembl
ENSG00000134508
resolver
ensp
ENSP00000256925
resolver
ensp
ENSP00000383321
resolver
ensp
ENSP00000413851
resolver
genesymbol
CABLES1
resolver
genesymbol_syn
CABLES
resolver
hgnc
HGNC:25097
resolver
uniprot
A7K6Y5
resolver
uniprot
B4DK60
resolver
uniprot
Q8N3Y8
resolver
uniprot
Q8NA22
resolver
uniprot
Q9BTG1
resolver
uniprot_entry
A7K6Y5_HUMAN
resolver
uniprot_entry
CABL1_HUMAN
resolver
uniprot_sec
B4DK60
resolver
uniprot_sec
Q8N3Y8
resolver
uniprot_sec
Q8NA22
resolver
uniprot_sec
Q9BTG1
resolver
amino_acid_sequence
MAAAAAAATTAACSSGSAGTDAAGASGLQQPPPQPQPQPAAAAPAQPPPEPPRKPRMDPRRRQAALSFLTNISLDGRLPPQDAEWGGGEEGGAAKPGAGGACGARTRFSLLAAAERGGCIALAAPGTPAAGLAAGSGPCLPQPSSLPPLIPGGHATVSGPGVARGFASPLGAGRASGEQWQPPRPAPLAACAQLQLLDGSGAAGQEELEEDDAFISVQVPAAAFLGSGTPGSGSGSRGRLNSFTQGILPIAFSRPTSQNYCSLEQPGQGGSTSAFEQLQRSRRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTRNGRIVLISGRRSFCSIFSVLPYRDSTQVGDLKLDGGRQSTGAVSLKEIIGLEGVELGADGKTVSYTQFLLPTNAFGARRNTIDSTSSFSQFRNLSHRSLSIGRASGTQGSLDTGSDLGDFMDYDPNLLDDPQWPCGKHKRVLIFPSYMTTVIDYVKPSDLKKDMNETFKEKFPHIKLTLSKIRSLKREMRKLAQEDCGLEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHEVKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLVQSS
uniprot
proteins
function
FUNCTION: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
67599
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-313 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
11585773
uniprot
proteins
pubmed
11706030
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14729625
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
633
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity). {ECO:0000250}.
uniprot
proteins