Tsc22d3
entrez
14605
canonical
uniprot
Q9Z2S7
canonical
ensembl
ENSMUSG00000031431
resolver
ensp
ENSMUSP00000062589
resolver
ensp
ENSMUSP00000108620
resolver
ensp
ENSMUSP00000192679
resolver
ensp
ENSMUSP00000192684
resolver
ensp
ENSMUSP00000192686
resolver
ensp
ENSMUSP00000192687
resolver
genesymbol
Tsc22d3
resolver
genesymbol_syn
Dsip1
resolver
genesymbol_syn
Dsipi
resolver
genesymbol_syn
Gilz
resolver
uniprot
B1AVF3
resolver
uniprot
C6EX03
resolver
uniprot
Q3UNI6
resolver
uniprot
Q8K160
resolver
uniprot
Q9EQN0
resolver
uniprot
Q9EQN1
resolver
uniprot
Q9EQN2
resolver
uniprot_entry
T22D3_MOUSE
resolver
uniprot_sec
B1AVF3
resolver
uniprot_sec
C6EX03
resolver
uniprot_sec
Q3UNI6
resolver
uniprot_sec
Q8K160
resolver
uniprot_sec
Q9EQN0
resolver
uniprot_sec
Q9EQN1
resolver
uniprot_sec
Q9EQN2
resolver
amino_acid_sequence
MNTEMYQTPMEVAVYQLHNFSISFFSSLLGGDVVSVKLDNSASGASVVALDNKIEQAMDLVKNHLMYAVREEVEVLKEQIRELLEKNSQLERENTLLKTLASPEQLEKFQSRLSPEEPAPEAPETPETPEAPGGSAV
uniprot
proteins
function
FUNCTION: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed:26752201). In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (By similarity). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (By similarity). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (PubMed:11397794). {ECO:0000250|UniProtKB:Q99576, ECO:0000269|PubMed:11397794, ECO:0000269|PubMed:26752201}.; FUNCTION: [Isoform 1]: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. {ECO:0000269|PubMed:20124407}.; FUNCTION: [Isoform 4]: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. {ECO:0000269|PubMed:20124407}.
uniprot
proteins
mass_dalton
15177
uniprot
proteins
protein_family
TSC-22/Dip/Bun family
uniprot
proteins
pubmed
11397794
uniprot
proteins
pubmed
11468175
uniprot
proteins
pubmed
12393603
uniprot
proteins
pubmed
15031210
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17147695
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20124407
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26752201
uniprot
proteins
pubmed
9430225
uniprot
proteins
sequence_length
137
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:20124407}. Nucleus {ECO:0000269|PubMed:20124407}. Note=Localization depends on differentiation status of myoblasts (PubMed:20124407). In undifferentiated myoblasts; localizes to the cytoplasm, but in differentiating myoblast; localizes to the nucleus (PubMed:20124407). {ECO:0000269|PubMed:20124407}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:20124407}. Nucleus {ECO:0000269|PubMed:20124407}. Note=Localization depends on differentiation status of myoblasts (PubMed:20124407). In undifferentiated myoblasts; localizes to the cytoplasm, but in differentiating myoblasts; localizes to the nucleus (PubMed:20124407). {ECO:0000269|PubMed:20124407}.
uniprot
proteins