GABRG3
entrez
2567
canonical
uniprot
Q99928
canonical
ensembl
ENSG00000182256
resolver
ensp
ENSP00000452244
resolver
ensp
ENSP00000479113
resolver
genesymbol
GABRG3
resolver
hgnc
HGNC:4088
resolver
uniprot
G3V594
resolver
uniprot
Q9HD46
resolver
uniprot
Q9NYT2
resolver
uniprot_entry
GBRG3_HUMAN
resolver
uniprot_sec
G3V594
resolver
uniprot_sec
Q9HD46
resolver
uniprot_sec
Q9NYT2
resolver
amino_acid_sequence
MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYWVGYLYL
uniprot
proteins
function
FUNCTION: Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride across the cell membrane down their electrochemical gradient (By similarity). {ECO:0000250|UniProtKB:P18507, ECO:0000250|UniProtKB:P28473}.
uniprot
proteins
mass_dalton
54289
uniprot
proteins
post_translational_modification
PTM: May be palmitoylated. {ECO:0000250|UniProtKB:P22723}.
uniprot
proteins
protein_family
GABRG3 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
26566883
uniprot
proteins
pubmed
8719414
uniprot
proteins
sequence_length
467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000255}. Cell membrane; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 257..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 284..303; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 312..332; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 447..467; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins