Tyms
entrez
29261
canonical
uniprot
P45352
canonical
ensembl
ENSRNOG00000037225
resolver
ensembl
ENSRNOG00055007718
resolver
ensembl
ENSRNOG00060004837
resolver
ensembl
ENSRNOG00065009297
resolver
ensp
ENSRNOP00000084093
resolver
ensp
ENSRNOP00055010305
resolver
ensp
ENSRNOP00060006026
resolver
ensp
ENSRNOP00065011108
resolver
enst
ENSRNOT00000093931
resolver
enst
ENSRNOT00055012922
resolver
enst
ENSRNOT00060008051
resolver
enst
ENSRNOT00065014859
resolver
genesymbol
Tyms
resolver
uniprot
A0JN23
resolver
uniprot_entry
TYSY_RAT
resolver
uniprot_sec
A0JN23
resolver
amino_acid_sequence
MLVEGSELQSGAQQPRTEAPQHGELQYLRQVEHIMRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGADYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV
uniprot
proteins
ec_number
2.1.1.45
uniprot
proteins
function
FUNCTION: Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant (Probable). Contributes to the mitochondrial and nuclear de novo thymidylate biosynthesis pathway (By similarity). {ECO:0000250|UniProtKB:P04818, ECO:0000305|PubMed:9894005}.
uniprot
proteins
mass_dalton
35017
uniprot
proteins
pathway_participation
PATHWAY: Pyrimidine metabolism; dTTP biosynthesis. {ECO:0000305|PubMed:9894005}.
uniprot
proteins
post_translational_modification
PTM: Sumoylated by UBE2I/UBC9. {ECO:0000250|UniProtKB:P04818}.
uniprot
proteins
protein_family
Thymidylate synthase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7711067
uniprot
proteins
pubmed
9894005
uniprot
proteins
sequence_length
307
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P04818}. Cytoplasm {ECO:0000250|UniProtKB:P04818}. Mitochondrion {ECO:0000250|UniProtKB:P04818}. Mitochondrion matrix {ECO:0000250|UniProtKB:P04818}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P04818}. Note=Localized to the nucleus during S and G2/M phasesof the cell cycle. As a component of the de novo thymidylate synthesis complex, localizes specifically to replication forks during DNA synthesis (By similarity). {ECO:0000250|UniProtKB:P04818}.
uniprot
proteins