EI24
entrez
9538
canonical
uniprot
O14681
canonical
ensembl
ENSG00000149547
resolver
ensp
ENSP00000278903
resolver
ensp
ENSP00000431633
resolver
ensp
ENSP00000479943
resolver
ensp
ENSP00000534242
resolver
enst
ENST00000527235
resolver
genesymbol
EI24
resolver
genesymbol_syn
PIG8
resolver
hgnc
HGNC:13276
resolver
uniprot
A8K7D6
resolver
uniprot
B4DKL6
resolver
uniprot
E9PK61
resolver
uniprot
Q9BUQ1
resolver
uniprot_entry
E9PK61_HUMAN
resolver
uniprot_entry
EI24_HUMAN
resolver
uniprot_sec
A8K7D6
resolver
uniprot_sec
B4DKL6
resolver
uniprot_sec
Q9BUQ1
resolver
amino_acid_sequence
MADSVKTFLQDLARGIKDSIWGICTISKLDARIQQKREEQRRRRASSVLAQRRAQSIERKQESEPRIVSRIFQCCAWNGGVFWFSLLLFYRVFIPVLQSVTARIIGDPSLHGDVWSWLEFFLTSIFSALWVLPLFVLSKVVNAIWFQDIADLAFEVSGRKPHPFPSVSKIIADMLFNLLLQALFLIQGMFVSLFPIHLVGQLVSLLHMSLLYSLYCFEYRWFNKGIEMHQRLSNIERNWPYYFGFGLPLAFLTAMQSSYIISGCLFSILFPLFIISANEAKTPGKAYLFQLRLFSLVVFLSNRLFHKTVYLQSALSSSTSAEKFPSPHPSPAKLKATAGH
uniprot
proteins
disease_involvement
DISEASE: Note=EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness.
uniprot
proteins
function
FUNCTION: Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
38965
uniprot
proteins
protein_family
EI24 family
uniprot
proteins
pubmed
11753653
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21154811
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9305847
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:21154811}; Multi-pass membrane protein {ECO:0000269|PubMed:21154811}. Cytoplasm {ECO:0000269|PubMed:21154811}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 77..97; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 238..255; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 257..277; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins