GRIA3
entrez
2892
canonical
uniprot
P42263
canonical
ensembl
ENSG00000125675
resolver
ensp
ENSP00000478489
resolver
ensp
ENSP00000478758
resolver
ensp
ENSP00000479607
resolver
ensp
ENSP00000481554
resolver
enst
ENST00000611689
resolver
enst
ENST00000616590
resolver
genesymbol
GRIA3
resolver
genesymbol_syn
GLUR3
resolver
genesymbol_syn
GLURC
resolver
genesymbol_syn
GluA3
resolver
hgnc
HGNC:4573
resolver
uniprot
A0A087WUM1
resolver
uniprot
D3DTF1
resolver
uniprot
Q17R51
resolver
uniprot
Q4VXD5
resolver
uniprot
Q4VXD6
resolver
uniprot
Q5XKG2
resolver
uniprot
Q9HDA0
resolver
uniprot
Q9HDA1
resolver
uniprot
Q9HDA2
resolver
uniprot
Q9P0H1
resolver
uniprot_entry
A0A087WUM1_HUMAN
resolver
uniprot_entry
GRIA3_HUMAN
resolver
uniprot_entry
Q17R51_HUMAN
resolver
uniprot_entry
Q5XKG2_HUMAN
resolver
uniprot_sec
D3DTF1
resolver
uniprot_sec
Q4VXD5
resolver
uniprot_sec
Q4VXD6
resolver
uniprot_sec
Q9HDA0
resolver
uniprot_sec
Q9HDA1
resolver
uniprot_sec
Q9HDA2
resolver
uniprot_sec
Q9P0H1
resolver
amino_acid_sequence
MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, X-linked, syndromic, Wu type (MRXSW) [MIM:300699]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXSW patients have moderate intellectual disability, and additional variable features such as macrocephaly, seizures, myoclonic jerks, autistic behavior, asthenic body habitus, distal muscle weakness and hyporeflexia. {ECO:0000269|PubMed:17989220, ECO:0000269|PubMed:24721225}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of calcium (PubMed:17989220). The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:17989220). In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (PubMed:21172611). {ECO:0000250|UniProtKB:P19492, ECO:0000250|UniProtKB:Q9Z2W9, ECO:0000269|PubMed:17989220, ECO:0000269|PubMed:21172611}.
uniprot
proteins
mass_dalton
101157
uniprot
proteins
protein_family
GRIA3 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
10602120
uniprot
proteins
pubmed
10644433
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17989220
uniprot
proteins
pubmed
21172611
uniprot
proteins
pubmed
24721225
uniprot
proteins
pubmed
30165711
uniprot
proteins
pubmed
7918660
uniprot
proteins
sequence_length
894
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17989220}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19492}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P19492}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19492}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P19492}.
uniprot
proteins
transmembrane_region
TRANSMEM 553..573; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 628..648; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 824..844; /note="Helical; Name=M4"; /evidence="ECO:0000250
uniprot
proteins