AZIN2
entrez
113451
canonical
uniprot
Q96A70
canonical
ensembl
ENSG00000142920
resolver
ensp
ENSP00000294517
resolver
ensp
ENSP00000362540
resolver
ensp
ENSP00000362542
resolver
ensp
ENSP00000581057
resolver
ensp
ENSP00000581058
resolver
ensp
ENSP00000581063
resolver
ensp
ENSP00000714636
resolver
ensp
ENSP00000714638
resolver
genesymbol
AZIN2
resolver
genesymbol_syn
ADC
resolver
genesymbol_syn
KIAA1945
resolver
genesymbol_syn
ODCP
resolver
hgnc
HGNC:29957
resolver
uniprot
B2RDU5
resolver
uniprot
D3DPQ9
resolver
uniprot
Q5TIF4
resolver
uniprot
Q5TIF5
resolver
uniprot
Q5TIF6
resolver
uniprot
Q8TF56
resolver
uniprot
Q96L54
resolver
uniprot
Q96L55
resolver
uniprot
Q96L56
resolver
uniprot
Q96L57
resolver
uniprot
Q96MD9
resolver
uniprot_entry
AZIN2_HUMAN
resolver
uniprot_sec
B2RDU5
resolver
uniprot_sec
D3DPQ9
resolver
uniprot_sec
Q5TIF4
resolver
uniprot_sec
Q5TIF5
resolver
uniprot_sec
Q5TIF6
resolver
uniprot_sec
Q8TF56
resolver
uniprot_sec
Q96L54
resolver
uniprot_sec
Q96L55
resolver
uniprot_sec
Q96L56
resolver
uniprot_sec
Q96L57
resolver
uniprot_sec
Q96MD9
resolver
amino_acid_sequence
MAGYLSESDFVMVEEGFSTRDLLKELTLGASQATTDEVAAFFVADLGAIVRKHFCFLKCLPRVRPFYAVKCNSSPGVLKVLAQLGLGFSCANKAEMELVQHIGIPASKIICANPCKQIAQIKYAAKHGIQLLSFDNEMELAKVVKSHPSAKMVLCIATDDSHSLSCLSLKFGVSLKSCRHLLENAKKHHVEVVGVSFHIGSGCPDPQAYAQSIADARLVFEMGTELGHKMHVLDLGGGFPGTEGAKVRFEEIASVINSALDLYFPEGCGVDIFAELGRYYVTSAFTVAVSIIAKKEVLLDQPGREEENGSTSKTIVYHLDEGVYGIFNSVLFDNICPTPILQKKPSTEQPLYSSSLWGPAVDGCDCVAEGLWLPQLHVGDWLVFDNMGAYTVGMGSPFWGTQACHITYAMSRVAWEALRRQLMAAEQEDDVEGVCKPLSCGWEITDTLCVGPVFTPASIM
uniprot
proteins
function
FUNCTION: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728). {ECO:0000269|PubMed:17900240, ECO:0000269|PubMed:20188728}.
uniprot
proteins
mass_dalton
49980
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteasomal-independent manner. {ECO:0000269|PubMed:17900240}.
uniprot
proteins
protein_family
ODC antizyme inhibitor subfamily
uniprot
proteins
protein_family
Orn/Lys/Arg decarboxylase class-II family
uniprot
proteins
pubmed
11587527
uniprot
proteins
pubmed
11853319
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14738999
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17900240
uniprot
proteins
pubmed
19718454
uniprot
proteins
pubmed
19756694
uniprot
proteins
pubmed
19832840
uniprot
proteins
pubmed
19956990
uniprot
proteins
pubmed
20188728
uniprot
proteins
sequence_length
460
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region. Membrane {ECO:0000250}. Cytoplasmic vesicle. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Golgi apparatus, cis-Golgi network {ECO:0000250}. Golgi apparatus, trans-Golgi network. Cytoplasmic granule. Cell projection, axon. Cell projection, dendrite. Perikaryon. Note=Colocalizes with KDEL receptors in ER-Golgi intermediate compartment (ERGIC). Translocates from the ERGIC structure to the cytoplasm in an antizyme-dependent manner. Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules (By similarity). Detected as vesicle-like pattern in neurite outgrowths. Localizes to the vesicular compartments of the secretory pathway, predominantly in the trans-Golgi network (TGN). Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules. {ECO:0000250}.
uniprot
proteins