PELI2
entrez
57161
canonical
uniprot
Q9HAT8
canonical
ensembl
ENSG00000139946
resolver
ensp
ENSP00000267460
resolver
enst
ENST00000267460
resolver
genesymbol
PELI2
resolver
hgnc
HGNC:8828
resolver
uniprot
B2RDY5
resolver
uniprot
Q9H716
resolver
uniprot_entry
PELI2_HUMAN
resolver
uniprot_entry
Q9H716_HUMAN
resolver
uniprot_sec
B2RDY5
resolver
amino_acid_sequence
MFSPGQEEHCAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASKAISCKGQHSISYTLSRNQTVVVEYTHDKDTDMFQVGRSTESPIDFVVTDTISGSQNTDEAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPDGHMDGLTTNGVLVMHPRGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGATLLWRTADGLFHTPTQKHIEALRQEINAARPQCPVGLNTLAFPSINRKEVVEEKQPWAYLSCGHVHGYHNWGHRSDTEANERECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNCIKLIFQGPID
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:17675297, PubMed:17997719, PubMed:38917796). Specifically recognizes and binds proteins phosphorylated on threonine residues (PubMed:19081057, PubMed:38917796). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 (PubMed:12860405, PubMed:17997719, PubMed:22669975). Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination (PubMed:12860405, PubMed:17997719). Acts as a negative regulator of cGAS-STING signaling: recognizes and binds phosphorylated STING1 and mediates 'Lys-63'-linked polyubiquitination of TBK1, inhibiting cGAS-STING signaling, while simultaneously enhancing the STING1-dependent NF-kappa-B axis (PubMed:38917796). May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation (PubMed:12804775). Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1 (PubMed:12804775). {ECO:0000269|PubMed:12804775, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:17675297, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:19081057, ECO:0000269|PubMed:22669975, ECO:0000269|PubMed:38917796}.
uniprot
proteins
mass_dalton
46435
uniprot
proteins
mutagenesis
MUTAGEN 106; /note="R->A: Abolishes binding to IRAK1. Abolished ability to recognize and bind proteins phosphorylated on threonine residues."; /evidence="ECO:0000269|PubMed:19081057, ECO:0000269|PubMed:38917796"; MUTAGEN 187; /note="T->A: Abolishes binding to IRAK1; when associated with A-188."; /evidence="ECO:0000269|PubMed:19081057"; MUTAGEN 188; /note="N->A: Abolishes binding to IRAK1; when associated with A-187."; /evidence="ECO:0000269|PubMed:19081057"; MUTAGEN 397..400; /note="CPFC->APFA: Abolished E3 ubiquitin-protein ligase activity."; /evidence="ECO:0000269|PubMed:38917796"; MUTAGEN 397; /note="C->A: Loss of IRAK1-polyubiquitination."; /evidence="ECO:0000269|PubMed:22669975"; MUTAGEN 400; /note="C->A: Loss of IRAK1-polyubiquitination."; /evidence="ECO:0000269|PubMed:22669975
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:17675297, ECO:0000269|PubMed:38917796}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by IRAK1 and IRAK4 enhancing its E3 ligase activity. {ECO:0000269|PubMed:12860405}.
uniprot
proteins
protein_family
Pellino family
uniprot
proteins
pubmed
11306823
uniprot
proteins
pubmed
12804775
uniprot
proteins
pubmed
12860405
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17675297
uniprot
proteins
pubmed
17997719
uniprot
proteins
pubmed
19081057
uniprot
proteins
pubmed
22669975
uniprot
proteins
pubmed
38917796
uniprot
proteins
sequence_length
420
uniprot
proteins