Skic8
entrez
66317
canonical
uniprot
Q9ERF3
canonical
ensembl
ENSMUSG00000061559
resolver
ensp
ENSMUSP00000056359
resolver
ensp
ENSMUSP00000113560
resolver
ensp
ENSMUSP00000123077
resolver
ensp
ENSMUSP00000208146
resolver
ensp
ENSMUSP00000345515
resolver
enst
ENSMUST00000051822
resolver
enst
ENSMUST00000121204
resolver
enst
ENSMUST00000130368
resolver
genesymbol
Skic8
resolver
genesymbol_syn
Wdr61
resolver
uniprot
A0ACM8Q1X9
resolver
uniprot
A0MNP4
resolver
uniprot
D6RDC7
resolver
uniprot
Q3U562
resolver
uniprot
Q9CWZ4
resolver
uniprot
Q9CZP1
resolver
uniprot_entry
A0ACM8Q1X9_MOUSE
resolver
uniprot_entry
A0MNP4_MOUSE
resolver
uniprot_entry
D6RDC7_MOUSE
resolver
uniprot_entry
SKI8_MOUSE
resolver
uniprot_sec
Q3U562
resolver
uniprot_sec
Q9CWZ4
resolver
uniprot_sec
Q9CZP1
resolver
amino_acid_sequence
MTNQYSILFKQEQAHDDAIWSVAWETNKKENIETVVTGSLDDLVKVWKWRDERLELQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQMKSIDAGPVDAWTLAFSPDSQYLATGTHMGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCIHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHVYDCPI
uniprot
proteins
function
FUNCTION: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency (PubMed:19345177). PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1 (By similarity). PAF1C is required for transcription of Hox and Wnt target genes (By similarity). PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL (By similarity). PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription (By similarity). PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors (By similarity). In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription (By similarity). Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3) (By similarity). Required for Hox gene transcription (By similarity). Also acts as a component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (By similarity). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (By similarity). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (By similarity). {ECO:0000250|UniProtKB:Q9GZS3, ECO:0000269|PubMed:19345177}.
uniprot
proteins
mass_dalton
33773
uniprot
proteins
protein_family
SKI8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19345177
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27749823
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9GZS3}. Cytoplasm {ECO:0000250|UniProtKB:Q9GZS3}.
uniprot
proteins