ATP1A4
entrez
480
canonical
uniprot
Q13733
canonical
ensembl
ENSG00000132681
resolver
ensp
ENSP00000357060
resolver
ensp
ENSP00000433094
resolver
genesymbol
ATP1A4
resolver
genesymbol_syn
ATP1AL2
resolver
hgnc
HGNC:14073
resolver
uniprot
Q504T2
resolver
uniprot
Q7Z4I9
resolver
uniprot
Q8TBN8
resolver
uniprot
Q8WXA7
resolver
uniprot
Q8WXH7
resolver
uniprot
Q8WY13
resolver
uniprot_entry
AT1A4_HUMAN
resolver
uniprot_sec
Q504T2
resolver
uniprot_sec
Q7Z4I9
resolver
uniprot_sec
Q8TBN8
resolver
uniprot_sec
Q8WXA7
resolver
uniprot_sec
Q8WXH7
resolver
uniprot_sec
Q8WY13
resolver
activity_regulation
ACTIVITY REGULATION: Specifically inhibited by an endogenous cardiac glycoside, ouabain. {ECO:0000269|PubMed:16175638, ECO:0000269|PubMed:16861705}.
uniprot
proteins
amino_acid_sequence
MGLWGKKGTVAPHDQSPRRRPKKGLIKKKMVKREKQKRNMEELKKEVVMDDHKLTLEELSTKYSVDLTKGHSHQRAKEILTRGGPNTVTPPPTTPEWVKFCKQLFGGFSLLLWTGAILCFVAYSIQIYFNEEPTKDNLYLSIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVIRGGEKMQINVQEVVLGDLVEIKGGDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPDFTHENPLETRNICFFSTNCVEGTARGIVIATGDSTVMGRIASLTSGLAVGQTPIAAEIEHFIHLITVVAVFLGVTFFALSLLLGYGWLEAIIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTTEEQTGKTFTKSSDTWFMLARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQSYSSVAEMREKNPKVAEIPFNSTNKYQMSIHLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMNDEMKEAFQNAYLELGGLGERVLGFCFLNLPSSFSKGFPFNTDEINFPMDNLCFVGLISMIDPPRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKIPISKVDASAAKAIVVHGAELKDIQSKQLDQILQNHPEIVFARTSPQQKLIIVEGCQRLGAVVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIMYTLTSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKRLPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDSYGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYTPGMDVALRMYPLKITWWLCAIPYSILIFVYDEIRKLLIRQHPDGWVERETYY
uniprot
proteins
ec_number
7.2.2.13
uniprot
proteins
function
FUNCTION: Sperm-specific catalytic alpha subunit of the Na(+)/K(+)-ATPase responsible for ATP-dependent Na(+)/K(+) exchange across the plasma membrane. Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze (PubMed:16861705). Plays an essential for sperm motility, capacitation, and male fertility by maintaining ionic gradients required for flagellar function and signaling (By similarity). {ECO:0000250|UniProtKB:Q9WV27, ECO:0000269|PubMed:16861705}.
uniprot
proteins
mass_dalton
114166
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIC subfamily
uniprot
proteins
pubmed
12119109
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16175638
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16861705
uniprot
proteins
pubmed
39596464
uniprot
proteins
pubmed
7809153
uniprot
proteins
sequence_length
1029
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16175638, ECO:0000269|PubMed:16861705}; Multi-pass membrane protein {ECO:0000269|PubMed:39596464}. Note=In mature sperm, located in the principle piece of the sperm flagellum.
uniprot
proteins
transmembrane_region
TRANSMEM 100..124; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:39596464, ECO:0007744|PDB:8ZYJ"; TRANSMEM 135..156; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:39596464, ECO:0007744|PDB:8ZYJ"; TRANSMEM 296..319; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:39596464, ECO:0007744|PDB:8ZYJ"; TRANSMEM 325..350; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:39596464, ECO:0007744|PDB:8ZYJ"; TRANSMEM 778..800; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:39596464, ECO:0007744|PDB:8ZYJ"; TRANSMEM 806..828; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:39596464, ECO:0007744|PDB:8ZYJ"; TRANSMEM 851..874; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:39596464, ECO:0007744|PDB:8ZYJ"; TRANSMEM 924..945; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:39596464, ECO:0007744|PDB:8ZYJ"; TRANSMEM 954..976; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:39596464, ECO:0007744|PDB:8ZYJ"; TRANSMEM 988..1013; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:39596464, ECO:0007744|PDB:8ZYJ
uniprot
proteins