Nectin3
entrez
58998
canonical
uniprot
Q9JLB9
canonical
ensembl
ENSMUSG00000022656
resolver
ensp
ENSMUSP00000023334
resolver
ensp
ENSMUSP00000023335
resolver
ensp
ENSMUSP00000093757
resolver
ensp
ENSMUSP00000222746
resolver
ensp
ENSMUSP00000222757
resolver
genesymbol
Nectin3
resolver
genesymbol_syn
Pvrl3
resolver
uniprot
Q059N7
resolver
uniprot
Q9D006
resolver
uniprot
Q9JLB7
resolver
uniprot
Q9JLB8
resolver
uniprot_entry
NECT3_MOUSE
resolver
uniprot_sec
Q059N7
resolver
uniprot_sec
Q9D006
resolver
uniprot_sec
Q9JLB7
resolver
uniprot_sec
Q9JLB8
resolver
amino_acid_sequence
MARTPGPAPLCPGGGKAQLSSAFPPAAGLLLPAPTPPPLLLLLIPLLLFSRLCGALAGSIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSTQTVAVHHPQYGFSVQGDYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAVCVAATGKPVAQIDWEGDLGEMESSTTSFPNETATIVSQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTVNYSGVYVCKVSNSLGQRSDQKVIYISDPPTTTTLQPTVQWHSSPADVQDIATEHKKLPFPLSTLATLKDDTIGTIIASVVGGALFLVLVSILAGVFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLHQDELDSYPDSVKKENKNPVNNLIRKDYLEEPEKTQWNNVENLTRFERPMDYYEDLKMGMKFVSDERYNESEDGLVSHVDGSVISRREWYV
uniprot
proteins
function
FUNCTION: Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions (PubMed:10744716, PubMed:11827984, PubMed:12121624, PubMed:12558799, PubMed:15328010, PubMed:16128743, PubMed:21798896). Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1 (PubMed:16128743). Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation (PubMed:16128743). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (PubMed:15328010). Also involved in the formation of cell-cell junctions, including adherens junctions and synapses (PubMed:11827984). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN1: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (PubMed:21798896). Plays a role in the morphology of the ciliary body (PubMed:15728677). {ECO:0000269|PubMed:10744716, ECO:0000269|PubMed:11827984, ECO:0000269|PubMed:12121624, ECO:0000269|PubMed:12558799, ECO:0000269|PubMed:15328010, ECO:0000269|PubMed:15728677, ECO:0000269|PubMed:16128743, ECO:0000269|PubMed:21798896}.
uniprot
proteins
mass_dalton
60583
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
10744716
uniprot
proteins
pubmed
11827984
uniprot
proteins
pubmed
12121624
uniprot
proteins
pubmed
12558799
uniprot
proteins
pubmed
12826663
uniprot
proteins
pubmed
15328010
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15728677
uniprot
proteins
pubmed
15741237
uniprot
proteins
pubmed
16128743
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16300961
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21798896
uniprot
proteins
sequence_length
549
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21798896}; Single-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000269|PubMed:11827984}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000269|PubMed:15328010}. Note=In the auditory epithelium, specificaly localizes to the apical side of the lateral membranes of supporting cells. {ECO:0000269|PubMed:21798896}.
uniprot
proteins
transmembrane_region
TRANSMEM 405..425; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins