Ahcy
entrez
29443
canonical
uniprot
P10760
canonical
ensembl
ENSRNOG00000017777
resolver
ensembl
ENSRNOG00055005580
resolver
ensembl
ENSRNOG00055024122
resolver
ensembl
ENSRNOG00060007906
resolver
ensembl
ENSRNOG00060026924
resolver
ensembl
ENSRNOG00065010890
resolver
ensembl
ENSRNOG00065027869
resolver
ensp
ENSRNOP00000024310
resolver
ensp
ENSRNOP00055006834
resolver
ensp
ENSRNOP00055033707
resolver
ensp
ENSRNOP00060009886
resolver
ensp
ENSRNOP00060038798
resolver
ensp
ENSRNOP00065013557
resolver
ensp
ENSRNOP00065039458
resolver
enst
ENSRNOT00000024310
resolver
enst
ENSRNOT00055008970
resolver
enst
ENSRNOT00055041423
resolver
enst
ENSRNOT00060013030
resolver
enst
ENSRNOT00060046660
resolver
enst
ENSRNOT00065017660
resolver
enst
ENSRNOT00065048058
resolver
genesymbol
Ahcy
resolver
uniprot_entry
SAHH_RAT
resolver
amino_acid_sequence
MADKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY
uniprot
proteins
ec_number
3.13.2.1
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:11927587). Binds copper ions (By similarity). {ECO:0000250|UniProtKB:P50247, ECO:0000269|PubMed:11927587}.
uniprot
proteins
mass_dalton
47538
uniprot
proteins
mutagenesis
MUTAGEN 131; /note="D->N: Strongly reduces S-adenosyl-L-homocysteine hydrolase activity."; /evidence="ECO:0000269|PubMed:11927587"; MUTAGEN 186; /note="K->N: Strongly reduces S-adenosyl-L-homocysteine hydrolase activity."; /evidence="ECO:0000269|PubMed:11927587"; MUTAGEN 190; /note="D->N: Strongly reduces S-adenosyl-L-homocysteine hydrolase activity."; /evidence="ECO:0000269|PubMed:11927587"; MUTAGEN 191; /note="N->S: Strongly reduces S-adenosyl-L-homocysteine hydrolase activity."; /evidence="ECO:0000269|PubMed:11927587"; MUTAGEN 245; /note="D->E: Changes active site geometry and alters affinity for NAD.
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. {ECO:0000305|PubMed:11927587}.
uniprot
proteins
protein_family
Adenosylhomocysteinase family
uniprot
proteins
pubmed
10387078
uniprot
proteins
pubmed
10913437
uniprot
proteins
pubmed
11741948
uniprot
proteins
pubmed
11927587
uniprot
proteins
pubmed
3027698
uniprot
proteins
pubmed
3759971
uniprot
proteins
pubmed
7744082
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P23526}. Melanosome {ECO:0000250|UniProtKB:P23526}. Nucleus {ECO:0000250|UniProtKB:P23526}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P23526}.
uniprot
proteins