HPR
entrez
3250
canonical
uniprot
P00739
canonical
ensembl
ENSG00000261701
resolver
ensp
ENSP00000441828
resolver
genesymbol
HPR
resolver
hgnc
HGNC:5156
resolver
uniprot
Q7LE20
resolver
uniprot
Q92658
resolver
uniprot
Q92659
resolver
uniprot
Q9ULB0
resolver
uniprot_entry
HPTR_HUMAN
resolver
uniprot_sec
Q7LE20
resolver
uniprot_sec
Q92658
resolver
uniprot_sec
Q92659
resolver
uniprot_sec
Q9ULB0
resolver
amino_acid_sequence
MSDLGAVISLLLWGRQLFALYSGNDVTDISDDRFPKPPEIANGYVEHLFRYQCKNYYRLRTEGDGVYTLNDKKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYHQVDIGLIKLKQKVLVNERVMPICLPSKNYAEVGRVGYVSGWGQSDNFKLTDHLKYVMLPVADQYDCITHYEGSTCPKWKAPKSPVGVQPILNEHTFCVGMSKYQEDTCYGDAGSAFAVHDLEEDTWYAAGILSFDKSCAVAEYGVYVKVTSIQHWVQKTIAEN
uniprot
proteins
function
FUNCTION: Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron. {ECO:0000269|PubMed:16778136}.
uniprot
proteins
mass_dalton
39030
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
1478675
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16778136
uniprot
proteins
pubmed
25037218
uniprot
proteins
pubmed
2987228
uniprot
proteins
pubmed
4018023
uniprot
proteins
pubmed
8945641
uniprot
proteins
sequence_length
348
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16778136}. Note=Secreted into blood plasma and associated with subtypes of high density lipoproteins (HDL). {ECO:0000269|PubMed:16778136}.
uniprot
proteins