Nras
entrez
24605
canonical
uniprot
Q04970
canonical
ensembl
ENSRNOG00000023079
resolver
ensembl
ENSRNOG00055020029
resolver
ensembl
ENSRNOG00060030547
resolver
ensembl
ENSRNOG00065030867
resolver
ensp
ENSRNOP00000036381
resolver
ensp
ENSRNOP00055027750
resolver
ensp
ENSRNOP00060044116
resolver
ensp
ENSRNOP00065043696
resolver
enst
ENSRNOT00055034226
resolver
enst
ENSRNOT00060053066
resolver
enst
ENSRNOT00065053199
resolver
genesymbol
Nras
resolver
uniprot
Q4KMB1
resolver
uniprot_entry
RASN_RAT
resolver
uniprot_sec
Q4KMB1
resolver
activity_regulation
ACTIVITY REGULATION: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
uniprot
proteins
amino_acid_sequence
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSEDGTQGCMGLPCVVM
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (By similarity). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity). {ECO:0000250|UniProtKB:P01111}.
uniprot
proteins
mass_dalton
21243
uniprot
proteins
post_translational_modification
PTM: Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by ABHD17A, ABHD17B and ABHD17C. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi. {ECO:0000250|UniProtKB:P01111}.; PTM: Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs). {ECO:0000250|UniProtKB:P01116}.; PTM: Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes. {ECO:0000250|UniProtKB:P01112}.; PTM: Phosphorylation at Ser-89 enhances NRAS association with its downstream effectors. {ECO:0000250|UniProtKB:P01111}.
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1714740
uniprot
proteins
pubmed
19319189
uniprot
proteins
pubmed
2105496
uniprot
proteins
pubmed
8313523
uniprot
proteins
pubmed
8344525
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P01111}; Lipid-anchor {ECO:0000250|UniProtKB:P01111}; Cytoplasmic side {ECO:0000250|UniProtKB:P01111}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P01111}; Lipid-anchor {ECO:0000250|UniProtKB:P01111}. Note=Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000250|UniProtKB:P01111}.
uniprot
proteins