Tac1
entrez
21333
canonical
uniprot
P41539
canonical
ensembl
ENSMUSG00000061762
resolver
ensp
ENSMUSP00000138818
resolver
ensp
ENSMUSP00000139347
resolver
ensp
ENSMUSP00000167091
resolver
genesymbol
Tac1
resolver
genesymbol_syn
Nka
resolver
genesymbol_syn
Nkna
resolver
genesymbol_syn
Tac2
resolver
uniprot
B7ZMQ2
resolver
uniprot
Q00073
resolver
uniprot
Q149W7
resolver
uniprot_entry
B7ZMQ2_MOUSE
resolver
uniprot_entry
Q149W7_MOUSE
resolver
uniprot_entry
TKN1_MOUSE
resolver
uniprot_sec
Q00073
resolver
amino_acid_sequence
MKILVAVAVFFLVSTQLFAEEIDANDDLNYWSDWSDSDQIKEAMPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSVEKQVALLKALYGHGQISHKRHKTDSFVGLMGKRALNSVAYERSAMQNYERRRK
uniprot
proteins
function
FUNCTION: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.; FUNCTION: [Substance P]: Is a ligand for Tacr1, and triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C. Substance P binding to Tacr1 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity). Is also a TACR3 agonist with low receptor affinity. Basic secretagogue neuropeptide released from the terminals of specific sensory nerves (PubMed:30686732). Acts as a ligand for Mrgprb2 receptor in mast cells, initiating a signaling that mediates neurogenic inflammation and pain (PubMed:30686732). Neurogenic inflammation includes mast cell activation, recruitment of immune cells and release of inflammatory mediators, such as cytokines and chemokines (PubMed:30686732). The inflammatory response can then activate or sensitize nociceptors, promoting pain (PubMed:30686732). Also acts as a ligand for Mrgpra1 receptor in mast cells, initiating a signaling that elicits itch (PubMed:30686732). {ECO:0000250|UniProtKB:P06767, ECO:0000269|PubMed:30686732}.; FUNCTION: [Neurokinin A]: Is a ligand for Tacr2, and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C. Binding to Tacr2 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP). {ECO:0000250|UniProtKB:P20366}.
uniprot
proteins
mass_dalton
15045
uniprot
proteins
post_translational_modification
PTM: [Substance P]: The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME). {ECO:0000250|UniProtKB:P20366}.
uniprot
proteins
protein_family
Tachykinin family
uniprot
proteins
pubmed
1708336
uniprot
proteins
pubmed
28219706
uniprot
proteins
pubmed
30686732
uniprot
proteins
sequence_length
130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.; SUBCELLULAR LOCATION: [Substance P]: Secreted {ECO:0000250|UniProtKB:P20366}.
uniprot
proteins