Scai
entrez
320271
canonical
uniprot
Q8C8N2
canonical
ensembl
ENSMUSG00000035236
resolver
ensp
ENSMUSP00000037194
resolver
ensp
ENSMUSP00000218040
resolver
ensp
ENSMUSP00000218042
resolver
ensp
ENSMUSP00000218044
resolver
genesymbol
Scai
resolver
uniprot
A2RTF5
resolver
uniprot
A3KGQ2
resolver
uniprot
Q8C409
resolver
uniprot
Q8C4E7
resolver
uniprot
Q8C8K2
resolver
uniprot_entry
Q8C4E7_MOUSE
resolver
uniprot_entry
SCAI_MOUSE
resolver
uniprot_sec
A2RTF5
resolver
uniprot_sec
A3KGQ2
resolver
uniprot_sec
Q8C409
resolver
uniprot_sec
Q8C8K2
resolver
amino_acid_sequence
MVRGARQSQQPRSRLAPRLSGTVEKPPRKRKSRTEFTLKETMSSGGAEDDIPQGERKTVTDFCYLLDKSKQLFNGLRDLPQYGQKQWQSYFGRTFDVYTKLWKFQQQHRQVLDNRYGLKRWQIGEIASKIGQLYYHYYLRTSETSYLNEAFSFYSAIRQRSYYSQVNKEDRPELVVKKLRYYARFIVVCLLLNKMDVVKDLVKELSDEIEDYTHRFNTEDQVEWNLVLQEVAAFIEADPVMVLNDDNTIVITSNRLAETGAPLLEQGMIVGQLSLADALIIGNCNNQVKFSELTVDMFRMLQALEREPMNLASQMNKPGIQEPADKPTRRENPHKYLLYKPTFSQLYTFLAASFKELPANSVLLIYLSATGVFPTGRSDGEGPYDFGGVLTNSNRDIINGDAIHKRNQSHKEMHCLHPGDLYPFTRKPLFIVVDSSNSVAYKNFTNLFGQPLVCLLSPTAYPKALQDQSQRGSLFTLFLNNPLMAFLFVSGLSSMRRGLWEKCQEYLRKINRDIAQLLTHSRSIDQAFLQFFGDEFLRLLLTRFVFCSATMRMHKAFRETRNYPESYPQLPRDETVENPHLQKHILELASILDVRNIFFENSMDDY
uniprot
proteins
function
FUNCTION: Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. {ECO:0000269|PubMed:19350017}.
uniprot
proteins
mass_dalton
70275
uniprot
proteins
protein_family
SCAI family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19350017
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
606
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000269|PubMed:19350017}. Cytoplasm {ECO:0000269|PubMed:19350017}. Note=Nuclear localization is required for inhibition of MRTFA.
uniprot
proteins
transmembrane_region
TRANSMEM 472..492; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins