Grid1
entrez
14803
canonical
uniprot
Q61627
canonical
ensembl
ENSMUSG00000041078
resolver
ensp
ENSMUSP00000044009
resolver
enst
ENSMUST00000043349
resolver
genesymbol
Grid1
resolver
uniprot
Q3UUL5
resolver
uniprot_entry
GRID1_MOUSE
resolver
uniprot_sec
Q3UUL5
resolver
amino_acid_sequence
MEALTLWLLPWICQCVTVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCMRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRSQSATQPRPSASATLHSAIWIVYGAFVQQGGESSVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQLEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSNPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHTGRCDLTSHSSTQTEGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRINSLMDEDIAHKQISPASIELSALEMGGLAPSQALEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPLPLSSSATMPSIQCKHRSPNGGLFRQSPVKTPIPMSFQPVPGGVLPEALDTSHGTSI
uniprot
proteins
function
FUNCTION: Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Instead, forms trans-synaptic adhesion complexes with presynaptic neurexins and cerebellins, regulating NMDA and AMPA receptor activity and influencing synaptic plasticity through signal transduction (PubMed:34135511). In the presence of NRX1B-CBLN1, forms cation-selective channels that are proposed to be gated by glycine and D-serine (PubMed:34936451). However, recent research disputes this ligand-gated cation channel activity (PubMed:39052831). Cation-selective ion channel can be triggered by GRM1 in dopaminergic neurons (PubMed:28696429). Also acts as a receptor for GABA, modulating inhibitory synaptic plasticity through non-ionotropic mechanisms (By similarity). {ECO:0000250|UniProtKB:Q9ULK0, ECO:0000269|PubMed:28696429, ECO:0000269|PubMed:34135511, ECO:0000269|PubMed:34936451, ECO:0000269|PubMed:39052831}.
uniprot
proteins
mass_dalton
112210
uniprot
proteins
mutagenesis
MUTAGEN 73; /note="F->D: Abolishes dimerization. Weakly interacts with C1q domain of CBLN1."; /evidence="ECO:0000269|PubMed:27418511"; MUTAGEN 617; /note="V->R: Loss of cation channel activity."; /evidence="ECO:0000269|PubMed:28696429"; MUTAGEN 940..944; /note="SRTLS->GQGHG: Impairs regulation of NMDAR postsynaptic response."; /evidence="ECO:0000269|PubMed:34135511"; MUTAGEN 944; /note="S->A: Impairs regulation of NMDAR postsynaptic response."; /evidence="ECO:0000269|PubMed:34135511"; MUTAGEN 968..983; /note="HRSPNGGLFRQSPVKT->GQGHG: Impairs regulation of AMPAR postsynaptic response."; /evidence="ECO:0000269|PubMed:34135511"; MUTAGEN 968..969; /note="HR->AA: Impairs regulation of AMPAR postsynaptic response."; /evidence="ECO:0000269|PubMed:34135511"; MUTAGEN 1006..1009; /note="GTSI->EYYV: No effect on regulation of AMPAR or NMDAR postsynaptic responses."; /evidence="ECO:0000269|PubMed:34135511
uniprot
proteins
protein_family
GRID1 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
1372507
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22220752
uniprot
proteins
pubmed
27418511
uniprot
proteins
pubmed
28696429
uniprot
proteins
pubmed
34135511
uniprot
proteins
pubmed
34936451
uniprot
proteins
pubmed
39052831
uniprot
proteins
sequence_length
1009
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:34135511}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 563..583; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 638..658; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 831..851; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins