Pdia3
entrez
14827
canonical
uniprot
P27773
canonical
ensembl
ENSMUSG00000027248
resolver
ensp
ENSMUSP00000028683
resolver
enst
ENSMUST00000028683
resolver
genesymbol
Pdia3
resolver
genesymbol_syn
Erp
resolver
genesymbol_syn
Erp60
resolver
genesymbol_syn
Grp58
resolver
uniprot
Q3TEI9
resolver
uniprot
Q3TIL2
resolver
uniprot
Q3UZK8
resolver
uniprot
Q8C2F4
resolver
uniprot
Q99LF6
resolver
uniprot_entry
PDIA3_MOUSE
resolver
uniprot_sec
Q3TEI9
resolver
uniprot_sec
Q3TIL2
resolver
uniprot_sec
Q3UZK8
resolver
uniprot_sec
Q8C2F4
resolver
uniprot_sec
Q99LF6
resolver
amino_acid_sequence
MRFSCLALLPGVALLLASARLAAASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNIESLVKEYDDNGEGITIFRPLHLANKFEDKTVAYTEKKMTSGKIKKFIQDSIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEVPVVAIRTAKGEKFVMQEEFSRDGKALEQFLQEYFDGNLKRYLKSEPIPESNEGPVKVVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATNPPIIQEEKPKKKKKAQEDL
uniprot
proteins
ec_number
5.3.4.1
uniprot
proteins
function
FUNCTION: Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity. {ECO:0000250|UniProtKB:P30101}.
uniprot
proteins
mass_dalton
56678
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|Ref.7}.; PTM: Within the major histocompatibility complex class I (MHC I) peptide loading complex forms reversible disulfide-linked heterodimers with TAPBP as part of its protein folding chaperone activity. This is essential to assist the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. {ECO:0000250|UniProtKB:P30101}.
uniprot
proteins
protein_family
Protein disulfide isomerase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
2033248
uniprot
proteins
pubmed
20400973
uniprot
proteins
pubmed
21093319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23395171
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7523108
uniprot
proteins
sequence_length
505
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:P30101}. Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:P11598}. Melanosome {ECO:0000250|UniProtKB:P30101}.
uniprot
proteins