Stim2
entrez
116873
canonical
uniprot
P83093
canonical
ensembl
ENSMUSG00000039156
resolver
ensp
ENSMUSP00000113174
resolver
ensp
ENSMUSP00000143855
resolver
enst
ENSMUST00000117661
resolver
enst
ENSMUST00000201469
resolver
genesymbol
Stim2
resolver
genesymbol_syn
Kiaa1482
resolver
uniprot
A5CVE4
resolver
uniprot
I1E4X8
resolver
uniprot
Q69ZI3
resolver
uniprot
Q80VF4
resolver
uniprot_entry
A5CVE4_MOUSE
resolver
uniprot_entry
I1E4X8_MOUSE
resolver
uniprot_entry
STIM2_MOUSE
resolver
uniprot_sec
Q69ZI3
resolver
uniprot_sec
Q80VF4
resolver
amino_acid_sequence
MLLFGLLVAGVADGCDLVPRHLRGRRASGSAGAAASPSAAAAGERQALLTDPCMSLSPPCFTEEDRFSLEALQTIHKQMDDDKDGGIEVDESDEFIREDMKYKDATNKHSHLHREDKHITVEDLWKQWKTSEVHNWTLEDTLQWLIEFVELPQYEKNFRDNNVKGTTLPRIAVHETSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRPPHNWMKDFILTISIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRTVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYSDHSWVVMPRVSIPPYPIAGGVDDLDEDTPPIVPQFPGTVAKPAGSLARSSSLCRSRRSIVPSSPQSQRAQLPAHAPLAAHPRHPHHPQHPQHSLPSPDPDILSVSSCPALYRNEEEEEAIYFTAEKQWEVPDTASECDSLNSSSGRKPSPPSSLEMYQTLSSRKISRDELSLEDSSRGESPVTADVSRGSPECVGLTETKSMIFSPASRVYNGILEKSCSMHQLSSGIPVPHPRHTSCSSAGNDSKPVQEASNVSRVSSIPHDLCHNGEKSKKPSKIKSLFKKKSK
uniprot
proteins
function
FUNCTION: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
83925
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250}.; PTM: Phosphorylated predominantly on Ser residues. {ECO:0000250}.
uniprot
proteins
pubmed
11463338
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
746
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 219..235; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins