NDUFAB1
entrez
4706
canonical
uniprot
O14561
canonical
ensembl
ENSG00000004779
resolver
ensp
ENSP00000007516
resolver
ensp
ENSP00000458770
resolver
ensp
ENSP00000552906
resolver
enst
ENST00000007516
resolver
enst
ENST00000570319
resolver
genesymbol
NDUFAB1
resolver
hgnc
HGNC:7694
resolver
uniprot
B2R4M1
resolver
uniprot
Q9UNV1
resolver
uniprot_entry
ACPM_HUMAN
resolver
uniprot_sec
B2R4M1
resolver
uniprot_sec
Q9UNV1
resolver
amino_acid_sequence
MASRVLSAYVSRLPAAFAPLPRVRMLAVARPLSTALCSAGTQTRLGTLQPALVLAQVPGRVTQLCRQYSDMPPLTLEGIQDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDVYE
uniprot
proteins
function
FUNCTION: Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) (PubMed:27626371). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:31664822). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). {ECO:0000250|UniProtKB:P52505, ECO:0000250|UniProtKB:Q9H1K1, ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:31664822}.
uniprot
proteins
mass_dalton
17417
uniprot
proteins
post_translational_modification
PTM: Phosphopantetheinylation at Ser-112 is essential for interactions with LYR motif-containing proteins. {ECO:0000269|PubMed:31664822}.
uniprot
proteins
protein_family
Acyl carrier protein (ACP) family
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
12611891
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19892738
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23157686
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27499296
uniprot
proteins
pubmed
27626371
uniprot
proteins
pubmed
28892042
uniprot
proteins
pubmed
30215512
uniprot
proteins
pubmed
31664822
uniprot
proteins
pubmed
35177605
uniprot
proteins
pubmed
9878551
uniprot
proteins
sequence_length
156
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12611891, ECO:0000269|PubMed:28892042}.
uniprot
proteins