IGF2BP3
entrez
10643
canonical
uniprot
O00425
canonical
ensembl
ENSG00000136231
resolver
ensp
ENSP00000258729
resolver
genesymbol
IGF2BP3
resolver
genesymbol_syn
IMP3
resolver
genesymbol_syn
KOC1
resolver
genesymbol_syn
VICKZ3
resolver
hgnc
HGNC:28868
resolver
uniprot
A0A4Z5
resolver
uniprot
Q63HM0
resolver
uniprot
Q6MZZ2
resolver
uniprot
Q86VB1
resolver
uniprot_entry
IF2B3_HUMAN
resolver
uniprot_sec
A0A4Z5
resolver
uniprot_sec
Q63HM0
resolver
uniprot_sec
Q6MZZ2
resolver
uniprot_sec
Q86VB1
resolver
amino_acid_sequence
MNKLYIGNLSENAAPSDLESIFKDAKIPVSGPFLVKTGYAFVDCPDESWALKAIEALSGKIELHGKPIEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNTDSETAVVNVTYSSKDQARQALDKLNGFQLENFTLKVAYIPDEMAAQQNPLQQPRGRRGLGQRGSSRQGSPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGNVETCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGPPSAMTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGKTVNELQNLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVKQHQQQKALQSGPPQSRRK
uniprot
proteins
function
FUNCTION: RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152}.
uniprot
proteins
mass_dalton
63705
uniprot
proteins
mutagenesis
MUTAGEN 213; /note="K->E: Partial reduction in interaction with m6A-modified mRNA; when associated with E-294. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, modestly impaired binding to ACTB and MYC transcripts and almost no effect on ELAVL1-, DHX9- and HNRNPU-binding, nor on subcellular location; when associated with E-294; 422-E-E-423 and 505-E-E-506."; /evidence="ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152"; MUTAGEN 294; /note="K->E: Partial reduction in interaction with m6A-modified mRNA; when associated with E-213. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, modestly impaired binding to ACTB and MYC transcripts and almost no effect on ELAVL1-, DHX9- and HNRNPU-binding, nor on subcellular location; when associated with E-213; 422-E-E-423 and 505-E-E-506."; /evidence="ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152"; MUTAGEN 423..424; /note="KQ->EE: Loss of interaction with m6A-modified mRNA; when associated with 505-E-E-506. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, modestly impaired binding to ACTB and MYC transcripts and almost no effect on ELAVL1-, DHX9- and HNRNPU-binding, nor on subcellular location; when associated with E-213; E-294 and 505-E-E-506."; /evidence="ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152"; MUTAGEN 505..506; /note="KG->EE: Loss of interaction with m6A-modified mRNA; when associated with 422-E-E-423. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, modestly impaired binding to ACTB and MYC transcripts and almost no effect on ELAVL1-, DHX9- and HNRNPU-binding, nor on subcellular location; when associated with E-213; E-294 and 422-E-E-423."; /evidence="ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152
uniprot
proteins
protein_family
RRM IMP/VICKZ family
uniprot
proteins
pubmed
10525192
uniprot
proteins
pubmed
11465943
uniprot
proteins
pubmed
12161597
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
12921532
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15601260
uniprot
proteins
pubmed
15644775
uniprot
proteins
pubmed
16049158
uniprot
proteins
pubmed
16541107
uniprot
proteins
pubmed
16814207
uniprot
proteins
pubmed
17192788
uniprot
proteins
pubmed
17289661
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20080952
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23640942
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29476152
uniprot
proteins
pubmed
9178771
uniprot
proteins
pubmed
9891060
uniprot
proteins
sequence_length
579
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, P-body {ECO:0000269|PubMed:29476152}. Cytoplasm, Stress granule {ECO:0000269|PubMed:29476152}. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules.
uniprot
proteins