Flad1
entrez
319945
canonical
uniprot
Q8R123
canonical
ensembl
ENSMUSG00000042642
resolver
ensp
ENSMUSP00000103049
resolver
ensp
ENSMUSP00000122252
resolver
genesymbol
Flad1
resolver
uniprot
Q3TSN6
resolver
uniprot
Q8BXQ1
resolver
uniprot_entry
FAD1_MOUSE
resolver
uniprot_sec
Q3TSN6
resolver
uniprot_sec
Q8BXQ1
resolver
amino_acid_sequence
MASRASELPPGSGRSVTAGIIIVGDEILKGHTQDTNTYFLCRTLRSLGVQVCRVSVVPDEVATIASEVNSFSRRFTHVLTAGGIGPTHDDVTFEAVAQAFGEELKPHPELQAAIKTLGGEGWEKLSMVPSSARLHYGTDPRTGHPFRFPLVSVRNVYLFPGIPELLRRVLEGLKGLFQNTAVQFHLKELYVAASEGSIAPILSEAQAHFGRRLSLGSYPDWSSNYFQVKLILDSEEKEPLEECLAYLTARLPQGSLVPYQPDAVEKAGEAVYKLAESGSCLGKKVAGALQTIETALAQYHLSQLCVGFNGGKDCTALLHLFHAAVQRKFPDVPKPLQILYIRSISPFPELEQFLQDTIKRYNLQVLEAEGNMKQALGELQEKHPQLEAVLMGTRRTDPYSCSLSHFSPTDPGWPSFMRINPLLDWTYRNIWEFLRQLFVPYCILYDRGYTSLGSRENTTQNPALKCLSPGGHPVYRPAYLLENEDEERNSRM
uniprot
proteins
ec_number
2.7.7.2
uniprot
proteins
ec_number
3.6.1.18
uniprot
proteins
ec_number
3.6.1.22
uniprot
proteins
function
FUNCTION: This enzyme has two activities: FAD diphosphatase activity and FAD synthase activity. FAD diphosphatase acts on FAD and NADH to produce FMN and NMNH(2-), respectively. FAD synthase catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In addition to its catalytic activities, the protein also facilitates the delivery of FAD to client apo-flavoproteins. The balance between FAD synthesis and hydrolysis may be regulated by redox-sensing cysteine residues. At a much lower rate, FAD synthase catalyzes the reverse pyrophosphorolytic reaction. {ECO:0000250|UniProtKB:Q8NFF5}.
uniprot
proteins
mass_dalton
54766
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.
uniprot
proteins
post_translational_modification
PTM: May form disulfide bonds. {ECO:0000250|UniProtKB:Q8NFF5}.
uniprot
proteins
protein_family
FAD1 subfamily
uniprot
proteins
protein_family
MoaB/Mog family; PAPS reductase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:D4A4P4}. Mitochondrion matrix {ECO:0000250|UniProtKB:D4A4P4}. Nucleus {ECO:0000250|UniProtKB:D4A4P4}.
uniprot
proteins