P59665
uniprot
P59665
canonical
amino_acid_sequence
MRTLAILAAILLVALQAQAEPLQARADEVAAAPEQIAADIPEVVVSLAWDESLAPKHPGSRKNMACYCRIPACIAGERRYGTCIYQGRLWAFCC
uniprot
proteins
function
FUNCTION: Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses or by promoting the activation and maturation of some APCs (PubMed:15616305, PubMed:17142766, PubMed:20220136, PubMed:24236072). Interacts with the essential precursor of cell wall synthesis lipid II to inhibit bacterial cell wall synthesis (PubMed:20214904). Inhibits adenovirus infection via inhibition of viral disassembly at the vertex region, thereby restricting the release of internal capsid protein pVI, which is required for endosomal membrane penetration during cell entry (PubMed:18191790). In addition, interaction with adenovirus capsid leads to the redirection of viral particles to TLR4 thereby promoting a NLRP3-mediated inflammasome response and interleukin 1-beta (IL-1beta) release (PubMed:35080426). Induces the production of proinflammatory cytokines including type I interferon (IFN) in plasmacytoid dendritic cells (pDCs) by triggering the degradation of NFKBIA and nuclear translocation of IRF1, both of which are required for activation of pDCs (PubMed:27031443). {ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:17142766, ECO:0000269|PubMed:17452329, ECO:0000269|PubMed:18191790, ECO:0000269|PubMed:20214904, ECO:0000269|PubMed:20220136, ECO:0000269|PubMed:24236072, ECO:0000269|PubMed:27031443, ECO:0000269|PubMed:35080426}.
uniprot
proteins
mass_dalton
10201
uniprot
proteins
mutagenesis
MUTAGEN 90; /note="W->A: Almost complete loss of bactericidal activity."; /evidence="ECO:0000269|PubMed:20220136
uniprot
proteins
post_translational_modification
PTM: ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production.; PTM: Phosphorylation at Tyr-85 has been found in some cancer cell lines, and interferes with ADP-ribosylation. {ECO:0000269|PubMed:21904558}.
uniprot
proteins
protein_family
Alpha-defensin family
uniprot
proteins
pubmed
1339298
uniprot
proteins
pubmed
1445872
uniprot
proteins
pubmed
1445873
uniprot
proteins
pubmed
15064728
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616305
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17142766
uniprot
proteins
pubmed
17452329
uniprot
proteins
pubmed
18191790
uniprot
proteins
pubmed
2019582
uniprot
proteins
pubmed
20214904
uniprot
proteins
pubmed
20220136
uniprot
proteins
pubmed
21904558
uniprot
proteins
pubmed
24236072
uniprot
proteins
pubmed
27031443
uniprot
proteins
pubmed
2917986
uniprot
proteins
pubmed
2918759
uniprot
proteins
pubmed
3174637
uniprot
proteins
pubmed
3370315
uniprot
proteins
pubmed
35080426
uniprot
proteins
pubmed
4056036
uniprot
proteins
pubmed
8325384
uniprot
proteins
pubmed
8477861
uniprot
proteins
pubmed
8530462
uniprot
proteins
sequence_length
94
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins