Dnmt3l
entrez
54427
canonical
uniprot
Q9CWR8
canonical
ensembl
ENSMUSG00000000730
resolver
ensp
ENSMUSP00000000746
resolver
ensp
ENSMUSP00000116970
resolver
ensp
ENSMUSP00000117827
resolver
ensp
ENSMUSP00000119571
resolver
ensp
ENSMUSP00000121562
resolver
ensp
ENSMUSP00000123015
resolver
enst
ENSMUST00000000746
resolver
enst
ENSMUST00000123940
resolver
enst
ENSMUST00000131825
resolver
enst
ENSMUST00000138785
resolver
enst
ENSMUST00000139539
resolver
enst
ENSMUST00000151242
resolver
genesymbol
Dnmt3l
resolver
uniprot
A3EWM2
resolver
uniprot
D3YUQ4
resolver
uniprot_entry
A3EWM2_MOUSE
resolver
uniprot_entry
D3YUQ4_MOUSE
resolver
uniprot_entry
DNM3L_MOUSE
resolver
amino_acid_sequence
MGSRETPSSCSKTLETLDLETSDSSSPDADSPLEEQWLKSSPALKEDSVDVVLEDCKEPLSPSSPPTGREMIRYEVKVNRRSIEDICLCCGTLQVYTRHPLFEGGLCAPCKDKFLESLFLYDDDGHQSYCTICCSGGTLFICESPDCTRCYCFECVDILVGPGTSERINAMACWVCFLCLPFSRSGLLQRRKRWRHQLKAFHDQEGAGPMEIYKTVSAWKRQPVRVLSLFRNIDKVLKSLGFLESGSGSGGGTLKYVEDVTNVVRRDVEKWGPFDLVYGSTQPLGSSCDRCPGWYMFQFHRILQYALPRQESQRPFFWIFMDNLLLTEDDQETTTRFLQTEAVTLQDVRGRDYQNAMRVWSNIPGLKSKHAPLTPKEEEYLQAQVRSRSKLDAPKVDLLVKNCLLPLREYFKYFSQNSLPL
uniprot
proteins
function
FUNCTION: Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (PubMed:11719692, PubMed:15318244, PubMed:15671018, PubMed:24074865). Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:15671018). Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:15671018). Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (By similarity). Plays a key role in embryonic stem cells and germ cells (PubMed:11719692, PubMed:15318244, PubMed:24074865). In germ cells, required for the methylation of imprinted loci together with DNMT3A (PubMed:11719692). In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (PubMed:15318244). Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation (PubMed:24074865). While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (PubMed:24074865). Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (PubMed:24074865). Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (PubMed:24074865). {ECO:0000250|UniProtKB:Q9UJW3, ECO:0000269|PubMed:11719692, ECO:0000269|PubMed:15318244, ECO:0000269|PubMed:15671018, ECO:0000269|PubMed:24074865}.
uniprot
proteins
mass_dalton
47993
uniprot
proteins
mutagenesis
MUTAGEN 297; /note="F->A,E: Loss of binding to DNMT3A."; /evidence="ECO:0000269|PubMed:18945701
uniprot
proteins
pubmed
11306809
uniprot
proteins
pubmed
11719692
uniprot
proteins
pubmed
15318244
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15671018
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18945701
uniprot
proteins
pubmed
24074865
uniprot
proteins
pubmed
32674113
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins