Scp2
entrez
25541
canonical
uniprot
P11915
canonical
ensembl
ENSRNOG00000011413
resolver
ensp
ENSRNOP00000075342
resolver
enst
ENSRNOT00000088049
resolver
genesymbol
Scp2
resolver
genesymbol_syn
Podn
resolver
genesymbol_syn
Scp-2
resolver
uniprot
A0A0G2KAC1
resolver
uniprot
Q63383
resolver
uniprot
Q642G0
resolver
uniprot_entry
A0A0G2KAC1_RAT
resolver
uniprot_entry
SCP2_RAT
resolver
uniprot_sec
Q63383
resolver
uniprot_sec
Q642G0
resolver
amino_acid_sequence
MPSVALNSPRLPRVFVVGVGMTKFMKPGGENSRDYPDLAKEAGQKALADRQIPYSAVEQACVGYVYGESTCGQRAIYHSLGLTGIPIINVNNNCSTGSTALFMAQQLVQGGLANCVLALGFEKMEKGSLGTKYSDRSNPLEKHIDVLINKYGMSACPFAPQLFGSAGKEHMETYGTKVEHFAKIGWKNHKHSVNNPYSQFQDEYSLDEIMKSRPVFDFLTVLQCCPTSDGAAAAIVSSEEFVQKHGLQSKAVEIVAQEMVTDMPSTFEEKSVIKMVGYDMSKEAARKCYEKSGLGPSDVDVIELHDCFSTNELLTYEALGLCPEGQGGALVDRGDNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQVPGAKVALQHNLGLGGAAVVTLYRMGFPEAASSFRTHQISAAPTSSAGDGFKANLIFKEIEKKLEEEGEEFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPDSDKKADCTITMADSDLLALMTGKMNPQSAFFQGKLKIAGNMGLAMKLQSLQLQPDKAKL
uniprot
proteins
ec_number
2.3.1.155
uniprot
proteins
ec_number
2.3.1.16
uniprot
proteins
ec_number
2.3.1.176
uniprot
proteins
function
FUNCTION: [Isoform SCPx]: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids (PubMed:8063752, PubMed:9325339). Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (PubMed:8063752, PubMed:9325339). Also active with medium and long straight chain 3-oxoacyl-CoAs (PubMed:10706581, PubMed:9325339). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (PubMed:8063752). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (PubMed:9553048). {ECO:0000269|PubMed:10706581, ECO:0000269|PubMed:8063752, ECO:0000269|PubMed:9325339, ECO:0000269|PubMed:9553048}.; FUNCTION: [Isoform SCP2]: Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis (By similarity). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (PubMed:8063752). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3 (By similarity) (PubMed:9553048). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (PubMed:9553048). {ECO:0000250|UniProtKB:P22307, ECO:0000250|UniProtKB:P32020, ECO:0000269|PubMed:8063752, ECO:0000269|PubMed:9553048}.
uniprot
proteins
mass_dalton
58813
uniprot
proteins
post_translational_modification
PTM: [Isoform SCP2]: preSCP2, a protein with a molecular mass of about 15 kDa, is processed into its mature form (SCP2) by proteolytic cleavage of a 20 residue leader sequence after translocation into peroxisomes. {ECO:0000250|UniProtKB:O62742}.
uniprot
proteins
protein_family
Thiolase family
uniprot
proteins
protein_family
Thiolase-like superfamily
uniprot
proteins
pubmed
10706581
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1915369
uniprot
proteins
pubmed
1985920
uniprot
proteins
pubmed
2034675
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2334427
uniprot
proteins
pubmed
2340090
uniprot
proteins
pubmed
3115977
uniprot
proteins
pubmed
3395344
uniprot
proteins
pubmed
8063752
uniprot
proteins
pubmed
9245689
uniprot
proteins
pubmed
9325339
uniprot
proteins
pubmed
9553048
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform SCP2]: Peroxisome {ECO:0000250|UniProtKB:P32020}. Cytoplasm {ECO:0000250|UniProtKB:P22307}. Mitochondrion {ECO:0000250|UniProtKB:P22307}.; SUBCELLULAR LOCATION: [Isoform SCPx]: Peroxisome {ECO:0000269|PubMed:8063752, ECO:0000269|PubMed:9325339}.
uniprot
proteins