Gabra5
entrez
29707
canonical
uniprot
P19969
canonical
ensembl
ENSRNOG00000010803
resolver
ensp
ENSRNOP00000072389
resolver
enst
ENSRNOT00000083894
resolver
genesymbol
Gabra5
resolver
genesymbol_syn
Gabra-5
resolver
uniprot_entry
GBRA5_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically potentiated by alphaxalone. Allosterically inhibited by pregnenolone sulfate. Inhibited by zinc and lanthanum. {ECO:0000269|PubMed:10462548}.
uniprot
proteins
amino_acid_sequence
MDNGMLSRFIMTKTLLVFCISMTLSSHFGFSQMPTSSVQDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKERELILNKSTNAFTTGKLTHPPNIPKEQLPGGTGNAVGTASIRASEEKTSESKKTYNSISKIDKMSRIVFPILFGTFNLVYWATYLNREPVIKGATSPK
uniprot
proteins
function
FUNCTION: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10462548, PubMed:1660002, PubMed:2153588). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10462548, PubMed:1660002, PubMed:2153588). GABAARs containing alpha-5/GABRA5 subunits are mainly extrasynaptic and contribute to the tonic GABAergic inhibition in the hippocampus (By similarity). Extrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes (By similarity). {ECO:0000250|UniProtKB:P31644, ECO:0000250|UniProtKB:Q8BHJ7, ECO:0000269|PubMed:10462548, ECO:0000269|PubMed:1660002, ECO:0000269|PubMed:2153588}.
uniprot
proteins
mass_dalton
52337
uniprot
proteins
protein_family
GABRA5 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
10462548
uniprot
proteins
pubmed
1660002
uniprot
proteins
pubmed
2153588
uniprot
proteins
pubmed
2157817
uniprot
proteins
pubmed
2561977
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P31644}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31644}. Cell membrane {ECO:0000250|UniProtKB:P31644}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31644}.
uniprot
proteins
transmembrane_region
TRANSMEM 261..281; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P31644"; TRANSMEM 287..308; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P31644"; TRANSMEM 319..340; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P31644"; TRANSMEM 430..450; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P31644
uniprot
proteins