Ap2b1
entrez
140670
canonical
uniprot
P62944
canonical
ensembl
ENSRNOG00000061543
resolver
ensembl
ENSRNOG00055029479
resolver
ensembl
ENSRNOG00060028921
resolver
ensembl
ENSRNOG00065021097
resolver
ensp
ENSRNOP00000070905
resolver
ensp
ENSRNOP00000072290
resolver
ensp
ENSRNOP00000073619
resolver
genesymbol
Ap2b1
resolver
genesymbol_syn
Clapb1
resolver
uniprot
P21851
resolver
uniprot
Q3ZB97
resolver
uniprot_entry
AP2B1_RAT
resolver
uniprot_entry
Q3ZB97_RAT
resolver
uniprot_sec
P21851
resolver
amino_acid_sequence
MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWILAELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN
uniprot
proteins
function
FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P63010, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838}.
uniprot
proteins
mass_dalton
104553
uniprot
proteins
mutagenesis
MUTAGEN 756; /note="Q->A: Abolishes interaction with PIP5K1C."; /evidence="ECO:0000269|PubMed:19287005"; MUTAGEN 804; /note="Q->A: Abolishes interaction with PIP5K1C."; /evidence="ECO:0000269|PubMed:19287005"; MUTAGEN 806; /note="A->F: Abolishes interaction with PIP5K1C."; /evidence="ECO:0000269|PubMed:19287005"; MUTAGEN 808; /note="K->E: Abolishes interaction with PIP5K1C."; /evidence="ECO:0000269|PubMed:19287005"; MUTAGEN 815; /note="Y->A: Abolishes interaction with PIP5K1C."; /evidence="ECO:0000269|PubMed:19287005
uniprot
proteins
protein_family
Adaptor complexes large subunit family
uniprot
proteins
pubmed
14745134
uniprot
proteins
pubmed
15473838
uniprot
proteins
pubmed
19287005
uniprot
proteins
pubmed
1969413
uniprot
proteins
pubmed
22484487
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2495531
uniprot
proteins
pubmed
7559550
uniprot
proteins
sequence_length
937
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250}.
uniprot
proteins