Rnf185
entrez
193670
canonical
uniprot
Q91YT2
canonical
ensembl
ENSMUSG00000020448
resolver
ensp
ENSMUSP00000067053
resolver
ensp
ENSMUSP00000076333
resolver
genesymbol
Rnf185
resolver
uniprot
Q6ZWS3
resolver
uniprot_entry
RN185_MOUSE
resolver
uniprot_sec
Q6ZWS3
resolver
amino_acid_sequence
MASKGPSASASTENSNAGGPSGSSNGTGESGGQDSTFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPGTPQYVDEQFLSRLFLFVALVIMFWLLIA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (By similarity). Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (By similarity). Protects cells from ER stress-induced apoptosis (By similarity). Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (By similarity). Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity (PubMed:28273161). Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (By similarity). {ECO:0000250|UniProtKB:Q96GF1, ECO:0000269|PubMed:28273161}.
uniprot
proteins
mass_dalton
20520
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q96GF1}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
27485036
uniprot
proteins
pubmed
28273161
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q96GF1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96GF1}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96GF1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96GF1}.
uniprot
proteins
transmembrane_region
TRANSMEM 131..151; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins