Il21
entrez
365769
canonical
uniprot
A3QPB9
canonical
ensembl
ENSRNOG00000017376
resolver
ensembl
ENSRNOG00055002203
resolver
ensembl
ENSRNOG00060006837
resolver
ensembl
ENSRNOG00065008720
resolver
ensp
ENSRNOP00000097142
resolver
ensp
ENSRNOP00055002612
resolver
ensp
ENSRNOP00060008365
resolver
ensp
ENSRNOP00065010320
resolver
enst
ENSRNOT00000110753
resolver
enst
ENSRNOT00055003505
resolver
enst
ENSRNOT00060011200
resolver
enst
ENSRNOT00065013873
resolver
genesymbol
Il21
resolver
uniprot_entry
IL21_RAT
resolver
amino_acid_sequence
MERTLVCLILIFLGTVAHKSSPQRPDHLLIRLRHLMDIVEQLKIYENDLDPELLTAPQDVKGQCEHEAFACFQKAKLKPSNTGNNKTFINDLLAQLRRRLPAKRTGNKQRHMAKCPSCDLYEKKTPKEFLERLKWLLQKMIHQHLS
uniprot
proteins
function
FUNCTION: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity). {ECO:0000250|UniProtKB:Q9ES17, ECO:0000250|UniProtKB:Q9HBE4}.
uniprot
proteins
mass_dalton
17065
uniprot
proteins
protein_family
IL-15/IL-21 family
uniprot
proteins
sequence_length
146
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9HBE4}.
uniprot
proteins