PHAF1
entrez
80262
canonical
uniprot
Q9BSU1
canonical
ensembl
ENSG00000125149
resolver
ensp
ENSP00000219139
resolver
ensp
ENSP00000455182
resolver
ensp
ENSP00000682245
resolver
genesymbol
PHAF1
resolver
genesymbol_syn
C16orf6
resolver
genesymbol_syn
C16orf70
resolver
hgnc
HGNC:29564
resolver
uniprot
Q9HA86
resolver
uniprot_entry
PHAF1_HUMAN
resolver
uniprot_sec
Q9HA86
resolver
amino_acid_sequence
MLDLEVVPERSLGNEQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQSPLSHDLILNLTQDGIKLMFDAFNQRLKVIEVCDLTKVKLKYCGVHFNSQAIAPTIEQIDQSFGATHPGVYNSAEQLFHLNFRGLSFSFQLDSWTEAPKYEPNFAHGLASLQIPHGATVKRMYIYSGNSLQDTKAPMMPLSCFLGNVYAESVDVLRDGTGPAGLRLRLLAAGCGPGLLADAKMRVFERSVYFGDSCQDVLSMLGSPHKVFYKSEDKMKIHSPSPHKQVPSKCNDYFFNYFTLGVDILFDANTHKVKKFVLHTNYPGHYNFNIYHRCEFKIPLAIKKENADGQTETCTTYSKWDNIQELLGHPVEKPVVLHRSSSPNNTNPFGSTFCFGLQRMIFEVMQNNHIASVTLYGPPRPGSHLRTAELP
uniprot
proteins
function
FUNCTION: Plays a regulatory role in autophagic activity. In complex with BCAS3, associates with the autophagosome formation site during both non-selective and selective autophagy. {ECO:0000269|PubMed:33499712}.
uniprot
proteins
mass_dalton
47524
uniprot
proteins
protein_family
PHAF1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
33499712
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:33499712}. Preautophagosomal structure {ECO:0000269|PubMed:33499712}. Note=The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner. {ECO:0000269|PubMed:33499712}.
uniprot
proteins