Riox1
entrez
71952
canonical
uniprot
Q9JJF3
canonical
ensembl
ENSMUSG00000046791
resolver
ensp
ENSMUSP00000057984
resolver
enst
ENSMUST00000053744
resolver
genesymbol
Riox1
resolver
genesymbol_syn
Mapjd
resolver
genesymbol_syn
No66
resolver
uniprot
B2RQV2
resolver
uniprot_entry
RIOX1_MOUSE
resolver
uniprot_sec
B2RQV2
resolver
amino_acid_sequence
MDELPNGNGAALLKRGRGRRRRHPQSQPRGASVLALPLRPRKIRRHRKSAAASRVAALRARALRSEDSDSKVAVASVRGKRKRPAELLEASRSAEPRPVSARPRSASATLPSRVEGWAALSRNLGTAAPPPPGSHADEPGRPRASPLQQVLTELNGIPSSRRRAARLFEWLLAPLPPDHFYRRLWEREAVLVRRQDRSYYEGLFSTADLDSMLRYEDVQFGQHLDAARYVDGRRETLNPPGRALPAAAWSLYRAGCSLRLLCPQAFSPTVWQFLAVLQEQFGSMAGSNVYLTPPDSQGFAPHYDDIEAFVLQLEGRKLWRVYRPRDPSEELALTSSPNFSQEDLGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLSTYQRNTWGDFLEAVLPLAVQAAIEENVEFRRGLPRDFMDYMGAQHSDSKDPRRTAFMEKVRVLVARLGHFAPVDAVADQRAKDFIHDSLPPVLTDRERALSVHGLPVRWEAGEPVNVGAQLTTETQVHMLQDGVARLVGEGGRLFLYHTVENSRVYHLEEPKCLEIHPQQADAMELLLRSYPEFVRVGDLPCDSVEDQLSLATMLYDKGLLLTKTPLVPS
uniprot
proteins
ec_number
1.14.11.27
uniprot
proteins
ec_number
1.14.11.79
uniprot
proteins
function
FUNCTION: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (PubMed:19927124). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (PubMed:19927124). Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (PubMed:19927124). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (PubMed:19927124). Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (PubMed:35210392). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (By similarity). Participates in MYC-induced transcriptional activation (By similarity). {ECO:0000250|UniProtKB:Q9H6W3, ECO:0000269|PubMed:19927124, ECO:0000269|PubMed:35210392}.
uniprot
proteins
mass_dalton
67557
uniprot
proteins
mutagenesis
MUTAGEN 302; /note="H->A: Abolished lysine demethylase activity; when associated with A-367."; /evidence="ECO:0000269|PubMed:19927124, ECO:0000269|PubMed:35210392"; MUTAGEN 367; /note="H->A: Abolished lysine demethylase activity; when associated with A-302."; /evidence="ECO:0000269|PubMed:19927124, ECO:0000269|PubMed:35210392
uniprot
proteins
protein_family
NO66 subfamily
uniprot
proteins
protein_family
ROX family
uniprot
proteins
pubmed
14742713
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19927124
uniprot
proteins
pubmed
35210392
uniprot
proteins
sequence_length
603
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:14742713}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19927124}.
uniprot
proteins