C9
entrez
117512
canonical
uniprot
Q62930
canonical
ensembl
ENSRNOG00000013736
resolver
ensp
ENSRNOP00000018545
resolver
genesymbol
C9
resolver
uniprot
Q5BKC4
resolver
uniprot
Q62957
resolver
uniprot_entry
CO9_RAT
resolver
uniprot_entry
Q5BKC4_RAT
resolver
uniprot_sec
Q62957
resolver
activity_regulation
ACTIVITY REGULATION: Membrane attack complex (MAC) assembly is inhibited by CD59, thereby protecting self-cells from damage during complement activation. CD59 acts by preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. MAC assembly is also inhibited by clusterin (CLU) chaperones that inhibit polymerization of C9. {ECO:0000250|UniProtKB:P02748}.
uniprot
proteins
amino_acid_sequence
MASGVTITLAIAIFALEINAQAPEPTPREEPSADALLPIDCRMSTWSQWSQCDPCLKQRFRSRSIEVFGQFQGKSCADALGDRQHCEPTQECEEVQENCGNDFQCETGRCIKRKLLCNGDNDCGDFSDESDCESDPRLPCRDRVVEESELGRTAGYGINILGMDPLGTPFDNEFYNGLCDRVRDGNTLTYYRKPWNVAFLAYETKADKNFRTENYEEQFEMFKTIVRDRTTSFNANLALKFTITEAPIKKVGVDEVSPEKNSSKPKDSSVDFQFSYFKKENFQRLSSYLSQTKKMFLHVKGMIQLGRFVMRNRGVMLTTTFLDDVKALPVSYEKGEYFGFLETYGTHYSSSGSLGGLYELIYVLDKASMKEKGVELSDVKRCLGFNLDVSLYTPLQTALEGPSLTANVNHSDCLKTGDGKVVNISRDHIIDDVISFIRGGTRKQAVLLKEKLLRGAKTIDVNDFINWASSLDDAPALISQKLSPIYNLIPLTMKDAYAKKQNMEKAIEDYVNEFSARKCYPCQNGGTAILLDGQCMCSCTIKFKGIACEISKQR
uniprot
proteins
function
FUNCTION: Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:9212048). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (By similarity). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (By similarity). Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore (By similarity). {ECO:0000250|UniProtKB:P02748, ECO:0000269|PubMed:9212048}.
uniprot
proteins
mass_dalton
62281
uniprot
proteins
post_translational_modification
PTM: Phosphorylation sites are present in the extracellular medium. {ECO:0000250|UniProtKB:P02748}.
uniprot
proteins
protein_family
Complement C6/C7/C8/C9 family
uniprot
proteins
pubmed
9212048
uniprot
proteins
sequence_length
554
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9212048}. Target cell membrane {ECO:0000269|PubMed:9212048}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P02748}. Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore. {ECO:0000250|UniProtKB:P02748}.
uniprot
proteins
transmembrane_region
TRANSMEM 233..240; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:P02748"; TRANSMEM 267..274; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:P02748"; TRANSMEM 376..383; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:P02748"; TRANSMEM 384..392; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:P02748
uniprot
proteins