Camk2g
entrez
12325
canonical
uniprot
Q923T9
canonical
ensembl
ENSMUSG00000021820
resolver
ensp
ENSMUSP00000071720
resolver
ensp
ENSMUSP00000079298
resolver
ensp
ENSMUSP00000098398
resolver
ensp
ENSMUSP00000278398
resolver
ensp
ENSMUSP00000278399
resolver
ensp
ENSMUSP00000278400
resolver
ensp
ENSMUSP00000278401
resolver
ensp
ENSMUSP00000278402
resolver
ensp
ENSMUSP00000278403
resolver
ensp
ENSMUSP00000278404
resolver
ensp
ENSMUSP00000278405
resolver
ensp
ENSMUSP00000278406
resolver
ensp
ENSMUSP00000278415
resolver
ensp
ENSMUSP00000278439
resolver
ensp
ENSMUSP00000278467
resolver
genesymbol
Camk2g
resolver
uniprot
Q3U3H3
resolver
uniprot
Q6ZWS7
resolver
uniprot
Q8BW40
resolver
uniprot
Q8VED3
resolver
uniprot_entry
KCC2G_MOUSE
resolver
uniprot_entry
Q6ZWS7_MOUSE
resolver
uniprot_entry
Q8BW40_MOUSE
resolver
uniprot_sec
Q3U3H3
resolver
uniprot_sec
Q8VED3
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity. {ECO:0000250|UniProtKB:Q13555}.
uniprot
proteins
amino_acid_sequence
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (By similarity). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (By similarity). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning (PubMed:30184290). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). {ECO:0000250|UniProtKB:Q13555, ECO:0000269|PubMed:30184290}.
uniprot
proteins
mass_dalton
59607
uniprot
proteins
mutagenesis
MUTAGEN 43; /note="K->M: Abolished calmodulin-dependent protein kinase activity. Abolished ability to phosphorylate STAT1."; /evidence="ECO:0000269|PubMed:11972023
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state (By similarity). {ECO:0000250|UniProtKB:Q13555}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11972023
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30184290
uniprot
proteins
sequence_length
529
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
uniprot
proteins