Tnfaip1
entrez
287543
canonical
uniprot
Q7TNY1
canonical
ensembl
ENSRNOG00000009069
resolver
ensembl
ENSRNOG00055025958
resolver
ensembl
ENSRNOG00060019827
resolver
ensembl
ENSRNOG00065023400
resolver
ensp
ENSRNOP00000012245
resolver
ensp
ENSRNOP00055036693
resolver
ensp
ENSRNOP00060028090
resolver
ensp
ENSRNOP00065032508
resolver
enst
ENSRNOT00000012245
resolver
enst
ENSRNOT00055044791
resolver
enst
ENSRNOT00060034252
resolver
enst
ENSRNOT00065039993
resolver
genesymbol
Tnfaip1
resolver
uniprot_entry
BACD2_RAT
resolver
amino_acid_sequence
MSGDTCLCPASGAKPKISGFKGGGLGNKYVQLNVGGSLHYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVTLPQSRQEIQELMAEAKYYLIQGLVSLCQAALQDKKDSYQPVCNIPIITSLREEDRLIESSTKPVVKLLYNRSNNKYSYTSNSDDHLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNVLLYETPRVPDNSLLEATSRSRSQASPSEDEDTFELRDRVRRIHVKRYSTYDDRQLGHQSAHRD
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis (By similarity). May enhance the PCNA-dependent DNA polymerase delta activity. {ECO:0000250, ECO:0000269|PubMed:15726626}.
uniprot
proteins
mass_dalton
36046
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA. {ECO:0000250}.
uniprot
proteins
protein_family
BACURD family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15726626
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endosome {ECO:0000250}. Note=Colocalizes with RHOB in endosomes. {ECO:0000250}.
uniprot
proteins