Lrat
entrez
64047
canonical
uniprot
Q9JI61
canonical
ensembl
ENSRNOG00000025608
resolver
ensembl
ENSRNOG00055021938
resolver
ensembl
ENSRNOG00060007355
resolver
ensembl
ENSRNOG00065030920
resolver
ensp
ENSRNOP00000035053
resolver
ensp
ENSRNOP00055030674
resolver
ensp
ENSRNOP00060009123
resolver
ensp
ENSRNOP00065043780
resolver
enst
ENSRNOT00000035411
resolver
enst
ENSRNOT00055037620
resolver
enst
ENSRNOT00060012100
resolver
enst
ENSRNOT00065053284
resolver
genesymbol
Lrat
resolver
uniprot_entry
LRAT_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by all-trans-retinyl alpha-bromoacetate and N-boc-L-biocytinyl-11-aminoundecane chloro-methyl ketone (BACMK). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MKNSMLEAASLLLEKLLLISNFKIFSVCAPGGGTGKKHPYEINSFLRGDVLEVSRTHFTHYGIYLGDNRVAHLMPDILLALTSDKERTQKVVSNKRLLPGVICKVASIRVDTVEDFAYGADILVNHLDETLKKKSLLNEEVARRAEQQLGLTPYSLLWNNCEHFVTYCRYGSPISPQAEKFHETVKILIRDQRSCLASAVLGLVSIIYTGLASYMTLPAVCIPFCLWMMSG
uniprot
proteins
ec_number
2.3.1.135
uniprot
proteins
function
FUNCTION: Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters (PubMed:3410848). Retinyl esters are storage forms of vitamin A (By similarity). LRAT plays a critical role in vision (By similarity). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (By similarity). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity). {ECO:0000250|UniProtKB:O95237, ECO:0000250|UniProtKB:Q9JI60, ECO:0000269|PubMed:17158102, ECO:0000269|PubMed:3410848}.
uniprot
proteins
mass_dalton
25810
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism.
uniprot
proteins
protein_family
H-rev107 family
uniprot
proteins
pubmed
11108736
uniprot
proteins
pubmed
17158102
uniprot
proteins
pubmed
18544127
uniprot
proteins
pubmed
1885578
uniprot
proteins
pubmed
3410848
uniprot
proteins
sequence_length
231
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Rough endoplasmic reticulum {ECO:0000269|PubMed:18544127}. Endosome, multivesicular body {ECO:0000269|PubMed:18544127}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18544127}. Note=Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells.
uniprot
proteins
transmembrane_region
TRANSMEM 195..215; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins