Psmc3
entrez
29677
canonical
uniprot
Q63569
canonical
ensembl
ENSRNOG00000011414
resolver
ensp
ENSRNOP00000015757
resolver
enst
ENSRNOT00000015757
resolver
genesymbol
Psmc3
resolver
genesymbol_syn
Tbp1
resolver
uniprot
A0ACM8Q3E9
resolver
uniprot
A6HNA2
resolver
uniprot
P97638
resolver
uniprot
Q6P6U2
resolver
uniprot_entry
A0ACM8Q3E9_RAT
resolver
uniprot_entry
A6HNA2_RAT
resolver
uniprot_entry
PRS6A_RAT
resolver
uniprot_sec
P97638
resolver
uniprot_sec
Q6P6U2
resolver
amino_acid_sequence
MNLLPTPESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIVQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000250|UniProtKB:P17980}.
uniprot
proteins
mass_dalton
49160
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
8607789
uniprot
proteins
pubmed
9266764
uniprot
proteins
sequence_length
439
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Colocalizes with TRIM5 in cytoplasmic bodies. {ECO:0000250|UniProtKB:O88685}.
uniprot
proteins