Hacl1
entrez
85255
canonical
uniprot
Q8CHM7
canonical
ensembl
ENSRNOG00000019630
resolver
ensp
ENSRNOP00000026588
resolver
ensp
ENSRNOP00000082285
resolver
ensp
ENSRNOP00000085929
resolver
enst
ENSRNOT00000026588
resolver
enst
ENSRNOT00000108746
resolver
enst
ENSRNOT00000111010
resolver
genesymbol
Hacl1
resolver
genesymbol_syn
2hpcl
resolver
genesymbol_syn
Hpcl2
resolver
genesymbol_syn
Phyh2
resolver
uniprot
A0A8I6A4D4
resolver
uniprot
A0A8I6G9A1
resolver
uniprot_entry
A0A8I6A4D4_RAT
resolver
uniprot_entry
A0A8I6G9A1_RAT
resolver
uniprot_entry
HACL1_RAT
resolver
amino_acid_sequence
MSESNSAEGSDRSEEQVSGAKVIAQALKTQDVEYMFGVVGIPVTEIALAAQELGIKYIGMRNEQAACYAASAVGYLTGRPGVCLVVSGPGLIHALGGMANANMNCWPLIVIGGSSERNQEAMGAFQEFPQVEACRLYSKFSARPSSIQHIPFVIEKAVRSSIYGRPGACYIDVPADLVTLQESTTSIKYKECCMPPPLSLAETSAVRAAASVLRSAKQPLLIIGKGAAYSHAEDSIRKLVELCNLPFLPTPMGKGVVPDNHPNCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQADVKFIQIDICAEELGNNVRPSVTLLGDVNAVSKQLLEQFVKNPWQYPTDSKWWETLREKRKNNEAVSKELASKKSLPMNYYTVFYHVQEQLPRNCFIVSEGANTMDIGRTVLQNYLPRHRLDAGSFGTMGVGLGFAIAAAVVAKERSPGQRVICVEGDSAFGFSGMEVETICRYNLPIIILVVNNNGIYQGFDADTWGKILNFQGTATTIPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQDSLRQALKDTSKPCLINIMIEPQSTRKAQDFHWLTRSNI
uniprot
proteins
ec_number
4.1.2.63
uniprot
proteins
function
FUNCTION: Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.; FUNCTION: Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid (PubMed:10468558). Involved also in the shortening of 2-hydroxy long-chain fatty acids (By similarity). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity). {ECO:0000250|UniProtKB:Q9QXE0, ECO:0000250|UniProtKB:Q9UJ83, ECO:0000269|PubMed:10468558}.
uniprot
proteins
mass_dalton
63616
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism.
uniprot
proteins
protein_family
TPP enzyme family
uniprot
proteins
pubmed
10468558
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
581
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:10468558}.
uniprot
proteins