Gabbr2
entrez
83633
canonical
uniprot
O88871
canonical
ensembl
ENSRNOG00000008431
resolver
ensp
ENSRNOP00000011573
resolver
enst
ENSRNOT00000011573
resolver
genesymbol
Gabbr2
resolver
genesymbol_syn
Gpr51
resolver
uniprot
A0A0A0MXV8
resolver
uniprot
Q9JK36
resolver
uniprot
Q9QWU2
resolver
uniprot_entry
A0A0A0MXV8_RAT
resolver
uniprot_entry
GABR2_RAT
resolver
uniprot_sec
Q9JK36
resolver
uniprot_sec
Q9QWU2
resolver
amino_acid_sequence
MASPPSSGQPRPPPPPPPPARLLLPLLLSLLLWLAPGAWGWTRGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHFRWRRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGWYEPAWWEQVHVEANSSRCLRRSLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQFEREYNSKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGKIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILSLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL
uniprot
proteins
function
FUNCTION: Component of a heterodimeric G protein-coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872315, PubMed:9872317, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:10658574, PubMed:9872317). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10924501, PubMed:9872315, PubMed:9872317, PubMed:9872744, Ref.4). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10457184, PubMed:10924501, PubMed:9872315, PubMed:9872317, PubMed:9872744). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:10457184, PubMed:9872317, PubMed:9872744). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10924501, PubMed:9872744). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (By similarity). {ECO:0000250|UniProtKB:O75899, ECO:0000269|PubMed:10075644, ECO:0000269|PubMed:10457184, ECO:0000269|PubMed:10658574, ECO:0000269|PubMed:10924501, ECO:0000269|PubMed:9872315, ECO:0000269|PubMed:9872317, ECO:0000269|PubMed:9872744, ECO:0000269|Ref.4}.
uniprot
proteins
mass_dalton
105751
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
protein_family
GABA-B receptor subfamily
uniprot
proteins
pubmed
10075644
uniprot
proteins
pubmed
10457184
uniprot
proteins
pubmed
10658574
uniprot
proteins
pubmed
10727622
uniprot
proteins
pubmed
10924501
uniprot
proteins
pubmed
14718537
uniprot
proteins
pubmed
20400944
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
9872315
uniprot
proteins
pubmed
9872317
uniprot
proteins
pubmed
9872744
uniprot
proteins
sequence_length
940
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9872315, ECO:0000269|PubMed:9872317, ECO:0000305|PubMed:10457184}; Multi-pass membrane protein {ECO:0000269|PubMed:9872317}. Postsynaptic cell membrane {ECO:0000269|PubMed:9872317}; Multi-pass membrane protein {ECO:0000269|PubMed:9872317}. Perikaryon {ECO:0000269|PubMed:14718537}. Cell projection, dendrite {ECO:0000269|PubMed:10457184}. Note=Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane (PubMed:10457184). In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane. {ECO:0000305|PubMed:10457184}.
uniprot
proteins
transmembrane_region
TRANSMEM 483..503; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 522..542; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 551..571; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 597..617; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 654..674; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 691..711; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 720..740; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins