GPR50
entrez
9248
canonical
uniprot
Q13585
canonical
ensembl
ENSG00000102195
resolver
ensp
ENSP00000218316
resolver
enst
ENST00000218316
resolver
genesymbol
GPR50
resolver
hgnc
HGNC:4506
resolver
uniprot
Q0VGG3
resolver
uniprot
Q3ZAR0
resolver
uniprot_entry
MTR1L_HUMAN
resolver
uniprot_sec
Q0VGG3
resolver
uniprot_sec
Q3ZAR0
resolver
amino_acid_sequence
MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIFNYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSVHFKPDSVHFKPASSNPKPITGHHVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTTADYPKPATTSHPKPTAADNPELSASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAASQLESDTIADLPDPTVVTTSTNDYHDVVVIDVEDDPDEMAV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration (PubMed:19699797). Promotes self-renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways (By similarity). Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalization (PubMed:21858214). Also plays a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration (PubMed:29572483). {ECO:0000250|UniProtKB:O88495, ECO:0000269|PubMed:16778767, ECO:0000269|PubMed:19699797, ECO:0000269|PubMed:21858214, ECO:0000269|PubMed:29572483}.; FUNCTION: [C-terminal domain]: Upon cleavage by CAPN1, functions as a scaffold in the nucleus for interacting partners such as GTF2I to promote FOS promoter activation. {ECO:0000250|UniProtKB:O88495, ECO:0000269|PubMed:19699797, ECO:0000269|PubMed:21858214, ECO:0000269|PubMed:31900622}.
uniprot
proteins
mass_dalton
67369
uniprot
proteins
post_translational_modification
PTM: Cleaved by CAPN1 in a calcium-dependent manner. {ECO:0000269|PubMed:31900622}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16436372
uniprot
proteins
pubmed
16778767
uniprot
proteins
pubmed
19699797
uniprot
proteins
pubmed
21858214
uniprot
proteins
pubmed
29572483
uniprot
proteins
pubmed
31900622
uniprot
proteins
pubmed
8647286
uniprot
proteins
sequence_length
617
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21858214}; Multi-pass membrane protein. Postsynaptic density {ECO:0000269|PubMed:19699797}.; SUBCELLULAR LOCATION: [C-terminal domain]: Nucleus {ECO:0000269|PubMed:31900622}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 65..85; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 240..260; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 274..294; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins