TMC2
entrez
117532
canonical
uniprot
Q8TDI7
canonical
ensembl
ENSG00000149488
resolver
ensp
ENSP00000351732
resolver
genesymbol
TMC2
resolver
genesymbol_syn
C20orf145
resolver
hgnc
HGNC:16527
resolver
uniprot
Q5JXT0
resolver
uniprot
Q5JXT1
resolver
uniprot
Q6UWW4
resolver
uniprot
Q6ZS41
resolver
uniprot
Q8N9F3
resolver
uniprot
Q9BYN2
resolver
uniprot
Q9BYN3
resolver
uniprot
Q9BYN4
resolver
uniprot
Q9BYN5
resolver
uniprot_entry
TMC2_HUMAN
resolver
uniprot_sec
Q5JXT0
resolver
uniprot_sec
Q5JXT1
resolver
uniprot_sec
Q6UWW4
resolver
uniprot_sec
Q6ZS41
resolver
uniprot_sec
Q8N9F3
resolver
uniprot_sec
Q9BYN2
resolver
uniprot_sec
Q9BYN3
resolver
uniprot_sec
Q9BYN4
resolver
uniprot_sec
Q9BYN5
resolver
amino_acid_sequence
MSHQVKGLKEEARGGVKGRVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQEFVEKYEGALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKTQCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEEKAMDFSVLWDFEGYIKYSALFYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLIIVIRSMASNTQGSTGEGESDNFTFSFKMFTSWDYLIGNSETADNKYASITTSFKESIVDEQESNKEENIHLTRFLRVLANFLIICCLCGSGYLIYFVVKRSQQFSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYHPRTGLKWQLGRIFALFLGNLYTFLLALMDDVHLKLANEETIKNITHWTLFNYYNSSGWNESVPRPPLHPADVPRGSCWETAVGIEFMRLTVSDMLVTYITILLGDFLRACFVRFMNYCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTIMSLPPSFDCGPFSGKNRMYDVLQETIENDFPTFLGKIFAFLANPGLIIPAILLMFLAIYYLNSVSKSLSRANAQLRKKIQVLREVEKSHKSVKGKATARDSEDTPKSSSKNATQLQLTKEETTPPSASQSQAMDKKAQGPGTSNSASRTTLPASGHLPISRPPGIGPDSGHAPSQTHPWRSASGKSAQRPPH
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system (PubMed:11850618). The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. MET channel is activated by tension in the tip-link extending from the side wall of one stereocilium to the tip of the adjacent shorter stereocilium, where the channel is located (By similarity). TMC2 MET channel is highly permeable to calcium and likely transports monovalent cations. Also involved in vestibular hair cell transduction current of the mammalian inner ear (By similarity). {ECO:0000250|UniProtKB:Q8R4P4, ECO:0000250|UniProtKB:Q8R4P5, ECO:0000269|PubMed:11850618}.
uniprot
proteins
mass_dalton
102610
uniprot
proteins
protein_family
TMC family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
11850618
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
sequence_length
906
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:E7FFT2}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the stereocilia tips of the cochlear hair cells and plasma membranes of cuticular plates. {ECO:0000250|UniProtKB:Q8R4P4}.
uniprot
proteins
transmembrane_region
TRANSMEM 264..284; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 337..357; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 432..452; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 509..529; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 694..714; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 751..771; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins