Cyct
entrez
13067
canonical
uniprot
P00015
canonical
ensembl
ENSMUSG00000056436
resolver
ensp
ENSMUSP00000028430
resolver
ensp
ENSMUSP00000360588
resolver
enst
ENSMUST00000028430
resolver
genesymbol
Cyct
resolver
uniprot_entry
CYC2_MOUSE
resolver
amino_acid_sequence
MGDAEAGKKIFVQKCAQCHTVEKGGKHKTGPNLWGLFGRKTGQAPGFSYTDANKNKGVIWSEETLMEYLENPKKYIPGTKMIFAGIKKKSEREDLIKYLKQATSS
uniprot
proteins
function
FUNCTION: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.; FUNCTION: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
11714
uniprot
proteins
post_translational_modification
PTM: Binds 1 heme c group covalently per subunit.; PTM: Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration. {ECO:0000250}.
uniprot
proteins
protein_family
Cytochrome c family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
240690
uniprot
proteins
pubmed
2834389
uniprot
proteins
sequence_length
105
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
uniprot
proteins