Capn15
entrez
50817
canonical
uniprot
Q9JLG8
canonical
ensembl
ENSMUSG00000037326
resolver
ensp
ENSMUSP00000148486
resolver
ensp
ENSMUSP00000148718
resolver
ensp
ENSMUSP00000288441
resolver
ensp
ENSMUSP00000288451
resolver
ensp
ENSMUSP00000288457
resolver
ensp
ENSMUSP00000288462
resolver
enst
ENSMUST00000212520
resolver
genesymbol
Capn15
resolver
genesymbol_syn
Solh
resolver
uniprot
A0A1D5RLS3
resolver
uniprot
Q6PEE9
resolver
uniprot_entry
A0A1D5RLS3_MOUSE
resolver
uniprot_entry
CAN15_MOUSE
resolver
uniprot_sec
Q6PEE9
resolver
amino_acid_sequence
MATVGEWSCARCTFLNPAGQRQCSICEAPRHKPDLDQILRLSVEEQKWPCARCTFRNFLGKEACEVCGFTPEPVPGAPLLPIINGVLPKPPTILVEPKGSGKEEAGPVRTAGLVATEPARGRPEGEEEREERGEEEEKEQEGEGERAEPGSGWACQRCTLHNTPVASSCSACGGPRKLSLPRIPPEALVVPEVVAPTGFHVVPAPSQPVLPGEGAEADSPSTSQGPTSTDQEPPRVPLFSPFSPTLQNNPVPRSRREVPPQLQPPVPEAVQSSASTSSKGPQQGPGRAAAGASRLAELLSGKELLPGKRLSVLEEEVPESSPARCESCSDVIDLAGDIVRYTPASPSSPDFTTWSCARCTLRNPTTAPRCSVCGGSKLHGFQEHSEPPTHCPDCGANKPGPCVGSCGRAPSAHKAVRLLPDRPGQWACPACTLINTPRAKHCAACHTPQLLVTQCRGATPLRRRESMHVEKRRQTDEGEAKALWENIVAFCRENSVNFVDDSFPPGPASVGFPVGDSVQQRVKQWLRPHEINCSVFRDHGTPWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEGAYQVRLCKDGTWTTVLVDDMLPCDEAGFLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLALQVSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDAAYESLGLRPRHAYSVLDVRDVQGSRLLRLRNPWGRFSWNGSWSDEWPHWPGHLRAELMPHGSSEGVFWMEYSDFIRYFDSVDICKVHSDWQEARVQGCFPSTAGGPVGVTALTVLERASLEFALFQEGSRRSDSVDSHLLDLCILVFRATFGTGGRLSLGRLLAHSKRAVKKFVNCDVMLEPGEYAVVCCAFNHWNPAPPGPPAQASSPSAGVPRGAPEPPGHVLAVYSSRLVMVEPVEAQPTTLADAIILLTESRGERHEGREGMTCYYLTHGWAGLIVVVENRHPKSYLHVQCDCTDSFNVVSTRGSLRTQDSVPPLHRQVLVILSQLEGNAGFSITHRLAHRKAAQAFLSDWTASRGTHSPPLTPDVAGLHGPRPL
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
function
FUNCTION: Calcium-dependent cysteine protease that functions as a non-proteasomal, ubiquitin-directed protease regulating cell adhesion through cleavage of E-cadherin/CDH1. Binds to ubiquitinated proteins via its N-terminal, preferentially recognizing longer polyubiquitin chains including both 'Lys-48- and 'Lys-63'-linked chains. Recognizes the ubiquitinated E-cadherin-catenin complex and cleaves E-cadherin in a calcium- and ubiquitination-dependent manner resulting in lysosomal degradation of the resultant fragment (By similarity). Plays a critical role in eye, brain and cerebellar development (PubMed:33951504). In the developing brain, may regulate transcription factor abundance including PAX2 and PAX5 levels. Additional putative substrates include P-cadherin/CDH3, DCX and TUBB3 (PubMed:40238785). {ECO:0000250|UniProtKB:O75808, ECO:0000269|PubMed:33951504, ECO:0000269|PubMed:40238785}.
uniprot
proteins
mass_dalton
118719
uniprot
proteins
protein_family
Peptidase C2 family
uniprot
proteins
pubmed
10708520
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
32885237
uniprot
proteins
pubmed
33951504
uniprot
proteins
pubmed
40238785
uniprot
proteins
sequence_length
1095
uniprot
proteins