APBA1
entrez
320
canonical
uniprot
Q02410
canonical
ensembl
ENSG00000107282
resolver
ensp
ENSP00000265381
resolver
genesymbol
APBA1
resolver
genesymbol_syn
MINT1
resolver
genesymbol_syn
X11
resolver
hgnc
HGNC:578
resolver
uniprot
O14914
resolver
uniprot
O60570
resolver
uniprot
Q5VYR8
resolver
uniprot_entry
APBA1_HUMAN
resolver
uniprot_sec
O14914
resolver
uniprot_sec
O60570
resolver
uniprot_sec
Q5VYR8
resolver
amino_acid_sequence
MNHLEGSAEVEVTDEAAGGEVNESVEADLEHPEVEEEQQQPPQQQHYVGRHQRGRALEDLRAQLGQEEEERGECLARSASTESGFHNHTDTAEGDVIAAARDGYDAERAQDPEDESAYAVQYRPEAEEYTEQAEAEHAEATHRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRGEDEPYSEPYADYGGLQEHVYEEIGDAPELDARDGLRLYEQERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERPPTPAGGRPDSPGLQAPAGQQRAVGPAGGGEAGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPMDGDSPSPGSSSPLGAESSSTSLHPSDPVEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKMAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQETMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
uniprot
proteins
function
FUNCTION: Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}.
uniprot
proteins
mass_dalton
92865
uniprot
proteins
mutagenesis
MUTAGEN 608; /note="F->V: Diminishes interaction with APP."; /evidence="ECO:0000269|PubMed:8887653
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20531236
uniprot
proteins
pubmed
23737971
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7678331
uniprot
proteins
pubmed
8887653
uniprot
proteins
pubmed
9321393
uniprot
proteins
pubmed
9395480
uniprot
proteins
pubmed
9614075
uniprot
proteins
sequence_length
837
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20531236}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:20531236}. Nucleus {ECO:0000269|PubMed:20531236}. Note=Only about 5% of the protein is located in the nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus {ECO:0000269|PubMed:23737971}.
uniprot
proteins