Abcb8
entrez
74610
canonical
uniprot
Q9CXJ4
canonical
ensembl
ENSMUSG00000028973
resolver
ensp
ENSMUSP00000072826
resolver
ensp
ENSMUSP00000110729
resolver
enst
ENSMUST00000073076
resolver
enst
ENSMUST00000115077
resolver
genesymbol
Abcb8
resolver
genesymbol_syn
Mitosur
resolver
uniprot
Q8C695
resolver
uniprot
Q8C7W4
resolver
uniprot_entry
MITOS_MOUSE
resolver
uniprot_sec
Q8C695
resolver
uniprot_sec
Q8C7W4
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity inhibited by ATP via ABCB8/MITOSUR subunit. {ECO:0000250|UniProtKB:Q9NUT2}.
uniprot
proteins
amino_acid_sequence
MLVHLFRFGIRGGPVPGWSLQSLRFQTFSAARSSDDRLSSHLLRTVAQLRVQLRAHLPRAPPASHWSPSAWCWVGGTLVVPAVLWQHPRLCLIALCEAKESPPAQPTRAPELRFNWKLFWHFLHPHLLALGAAIVLALGAALVNVQIPLLLGQLVEIVAKYTRDHMGSFVSESRKLSVQLLLLYGVQGLLTFGYLVLLSHIGERMAMDMRKALFSSLLRQDIAFFDAKKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVIGSLVSLSMLSPRLTLMLAVVTPALMGVGTLMGSGLRKLSRQCQEQIARATGVADEALGNVRTVRAFAMEKREEERYQAELESCCCKAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLKGGDLMSFLVASQTVQRSMASLSVLFGQVVRGLSAGARVFEYMALSPVIPLTGGYCIPNKDIRGSITFQNVTFSYPCRPGFNVLKDFTLKLPSGKIVALVGQSGGGKTTVASLLERFYDPEAGSVTLDGHDLRTLNPSWLRGQVIGFISQEPVLFATTIMENIRFGKLDASDEEVYTAAREANAHEFISSFPDGYSTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRAAHSIIVMANGQVCEAGTHEELLKKGGLYSELIRRQTLDASLTSTPPAEKPEDPKSCQSKA
uniprot
proteins
function
FUNCTION: ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix (By similarity). Plays a role in mitochondrial iron transport (PubMed:22375032). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (PubMed:22375032). {ECO:0000250|UniProtKB:Q9NUT2, ECO:0000269|PubMed:22375032}.
uniprot
proteins
mass_dalton
78000
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCB family
uniprot
proteins
protein_family
Multidrug resistance exporter (TC 3.A.1.201) subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22375032
uniprot
proteins
sequence_length
717
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9NUT2}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
uniprot
proteins
transmembrane_region
TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 178..198; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 278..298; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 365..385; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins