RADX
entrez
55086
canonical
uniprot
Q6NSI4
canonical
ensembl
ENSG00000147231
resolver
ensp
ENSP00000361623
resolver
ensp
ENSP00000361628
resolver
ensp
ENSP00000667624
resolver
genesymbol
RADX
resolver
genesymbol_syn
CXorf57
resolver
hgnc
HGNC:25486
resolver
uniprot
H7BY89
resolver
uniprot
Q4G0L7
resolver
uniprot
Q5JQS1
resolver
uniprot
Q5JRF9
resolver
uniprot
Q6PHY5
resolver
uniprot
Q6PII9
resolver
uniprot
Q6PJU8
resolver
uniprot
Q9H7W5
resolver
uniprot
Q9NWA6
resolver
uniprot_entry
RADX_HUMAN
resolver
uniprot_sec
H7BY89
resolver
uniprot_sec
Q4G0L7
resolver
uniprot_sec
Q5JQS1
resolver
uniprot_sec
Q5JRF9
resolver
uniprot_sec
Q6PHY5
resolver
uniprot_sec
Q6PII9
resolver
uniprot_sec
Q6PJU8
resolver
uniprot_sec
Q9H7W5
resolver
uniprot_sec
Q9NWA6
resolver
amino_acid_sequence
MSGESGQPEAGPSHAGLDWPNPERNRAGVPGGVIRRAGSQGPRSWIQKVLEQIMDSPRQCVTPSEVVPVTVLAVQRYLLEDEPRDTVPKPPLYCYDVTISDGVYQEKCYLDPSLNSLVYQNILKVGIQMRISRVSCLYNEKRIGQGILCIDNVHCGETSDSISLETPFRNRAHQEKPERPLRGGKSHYLALWNNEDPYGDIWLTDKQPEEHNFSDTKIISLSHLEMTWTNRRNFPALLVRILHKSKLRYYGKPDKKMIEPYQTFLEVADSSGTVSVIMWNALCPEWYKSLRVGLVLLLQDYSVKKSYPFRIQPVPVDPQIKLISTMEICLNLRDPPTNIIIIPEKQVKPEWRLPKLNHRFTTRSELDDMPENCICDVIGLLVFVGRVQRSKKKENREDFWSYRWIHIADGTSEQPFIVELFSTSQPEIFENIYPMAYFVCTQLKVVRNDNQVPKLLYLTTTNESGVFITGHRGQPYTYDAKVKNFIQWIRTKSDSGEQKNMVIGGYYPYPPVPETFSKYSSSIKVESLLTAISEVRKEIEDLQYREQKRIAIQGIITAIKYIPHSSATESASASETLRNANRPSTSQAARVEIQERNGKRHQDDEPVNSQYFQTTSTNLSLSNKIRILQGPHANPVAVPQPGASVQTKGIKPGMPSIFNRRANINANLQGKARKTISDRWESQLWREKKFGLIDHLHYSRVYPESIPRKFMFEHRKFLSDQYNSQPAKYVPPEGRPPKLDDFKSARSLGHFEVTILGLNHEIAIDVAFLPMYCPEDIRTSQIDTLLTSMNYSCAYPQDTTGNDRLPGPRAVAGDIIKAATELDRVHIVGILDICNLGNNKVEVYLHKIYSPENTS
uniprot
proteins
function
FUNCTION: Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed:28735897). {ECO:0000269|PubMed:28735897}.
uniprot
proteins
mass_dalton
97554
uniprot
proteins
mutagenesis
MUTAGEN 240; /note="R->E: Decreased binding to single-stranded DNA; when associated with E-248; 252-E--E-256; A-279; E-304; E-310 and A-327."; /evidence="ECO:0000269|PubMed:28735897"; MUTAGEN 248; /note="R->E: Decreased binding to single-stranded DNA; when associated with E-240; 252-E--E-256; A-279; E-304; E-310 and A-327."; /evidence="ECO:0000269|PubMed:28735897"; MUTAGEN 252..256; /note="KPDKK->EPDEE: Decreased binding to single-stranded DNA; when associated with E-240; E-248; A-279; E-304; E-310 and A-327."; /evidence="ECO:0000269|PubMed:28735897"; MUTAGEN 279; /note="W->A: Decreased binding to single-stranded DNA; when associated with E-240; E-248; 252-E--E-256; E-304; E-310 and A-327."; /evidence="ECO:0000269|PubMed:28735897"; MUTAGEN 304; /note="K->E: Decreased binding to single-stranded DNA; when associated with E-240; E-248; 252-E--E-256; A-279; E-310 and A-327."; /evidence="ECO:0000269|PubMed:28735897"; MUTAGEN 310; /note="R->E: Decreased binding to single-stranded DNA; when associated with E-240; E-248; 252-E--E-256; A-279; E-304 and A-327."; /evidence="ECO:0000269|PubMed:28735897"; MUTAGEN 327; /note="E->A: Decreased binding to single-stranded DNA; when associated with E-240; E-248; 252-E--E-256; A-279; E-304 and E-310."; /evidence="ECO:0000269|PubMed:28735897
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
28735897
uniprot
proteins
sequence_length
855
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:28735897}. Note=Recruited to replication forks. {ECO:0000269|PubMed:28735897}.
uniprot
proteins