Slc48a1
entrez
67739
canonical
uniprot
Q9D8M3
canonical
ensembl
ENSMUSG00000081534
resolver
ensp
ENSMUSP00000112644
resolver
enst
ENSMUST00000117892
resolver
genesymbol
Slc48a1
resolver
genesymbol_syn
Hrg1
resolver
uniprot
Q3UU69
resolver
uniprot
Q9DCK0
resolver
uniprot_entry
HRG1_MOUSE
resolver
uniprot_sec
Q3UU69
resolver
uniprot_sec
Q9DCK0
resolver
amino_acid_sequence
MAPSRLQLGLRAAYSGFSSVAGFSIFFVWTVVYRQPGTAAMGGLAGVLALWVLVTHVMYMQDYWRTWLRGLRGFFFVGALFSAVSVSAFCTFLALAITQHQSLKDPNSYYLSCVWSFISFKWAFLLSLYAHRYRADFADISILSDF
uniprot
proteins
function
FUNCTION: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. In macrophages of the reticuloendothelial system, is the heme transporter for heme-iron recycling. Essential for macrophage iron homeostasis, transports heme from the phagolysosome to the cytoplasm during erythrophagocytosis (EP). {ECO:0000269|PubMed:23395172, ECO:0000269|PubMed:34713217}.
uniprot
proteins
mass_dalton
16489
uniprot
proteins
protein_family
HRG family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23395172
uniprot
proteins
pubmed
34713217
uniprot
proteins
sequence_length
146
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:23395172}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:23395172}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:23395172}; Multi-pass membrane protein {ECO:0000255}. Note=In macrophages, specifically localizes to the phagolysosomal membranes during erythrophagocytosis. {ECO:0000269|PubMed:23395172}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 74..94; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins