Arhgap32
entrez
330914
canonical
uniprot
Q811P8
canonical
ensembl
ENSMUSG00000041444
resolver
ensp
ENSMUSP00000128448
resolver
ensp
ENSMUSP00000133898
resolver
genesymbol
Arhgap32
resolver
genesymbol_syn
Grit
resolver
genesymbol_syn
Kiaa0712
resolver
genesymbol_syn
Rics
resolver
uniprot
B9EHJ8
resolver
uniprot
Q6A010
resolver
uniprot_entry
RHG32_MOUSE
resolver
uniprot_sec
B9EHJ8
resolver
uniprot_sec
Q6A010
resolver
amino_acid_sequence
METESETSSLGDDSVFWLDCEGVTQLTDGDEEEREESFRKMKSSIHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLTLKSCGSTASTKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLTELPRSDVLKDSPESVTQMLTAYLSRLSTIAGNKINCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQVGLFPGHCVELINQKVPQSVTNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGKISAVMQEGAASLSRPKSLLVSSPSTKLLTLEEAQARTQAQVSSPIVTENKYIEVGEGPAALQGKFHTVIEFPLERKRPQNKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEESLTSLHAVDGDSKLFRPRRPRSSSDALSASFNGDVLGNRCNSYDNLPHDNESEEEVGLLHIPALVSPHSAEDVDLSPPDIGVASLDFDPMSFQCSPPKAESECLESGASFLDSLGYTRDKLSPSKKDAEAGGSQSQTPGSTASSEPVSPVQEKLSPFFTLDLSPTDDKSSKPSSFTEKVVYAFSPKIGRKLSKSPSMNISEPISVTLPPRVSEVIGTVSNTVAQNASPTSWDKSVEERDVINRSPTQLQLGKMKAGEREAQETCEPEAQPLEQGAAEEVELPGTEERPVLSSQSKAVPSGQSQTGAVTHDPPQDPVPVSSVSLIPPPPPPKNVARMLALALAESAQQASSQTLKRPGASQAGCTSYGDTAVVPSEEKLPSSYSSLTLDKTCFQTDRPAEQFHPQINGLGNCNQPLPEAAAMGGPTQSNTTDSGEQLHQVDLIGNSLHRNHISGDPEKARSTSAPLTDSEKSDDHGSFPEDHAGKSSVSTVSFLEQDQSPLHFSCGDQPLSYLGTSVDKPHHSSELTDKSPMPSTLPRDKAHHPLSGSPEENSSTATMAYMMATPARAEPSNSEASRVLAEQPSAADFVAATLQRTHRTNRPLPPPPSQRPAEQPPVVGQVQEAPSIGLNNSHKVQGTAPAPERPPESRAMGDPAPIFLSDGTAAAQCPMGASAPQPGLPEKVRESSRAPPLHLRAESFPGHSCGFAAPVPPTRTMESKMAAALHSSAADATSSSNYHSFVPSSASVDDVMPVPLPVSQPKHASQKIAYSSFARPDVTAEPFGPENCLHFNMTPNCQFRPQSVPPHHNKLEPHQVYGARSEPPASMGPRYNTYVAPGRNMSGHHSKPCSRVEYVSSLGSSVRNPCCPEDILPYPTIRRVQSLHAPPPSMIRSVPISRTEVPPDDEPAYCPRPVYQYKPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYSSSSSSYYSPEGALCDVDAYGTVQLRPLHRLSSRDFAFYNPRLQGKNVYNYAGLPPRPRANATGYFSGNDHNVVTMPPTADGKHTYTSWDLEDMEKYRMQSIRRESRARQKVKGPIMSQYDNMTPAVQEDLGGIYVIHLRSKSDPGKTGLLSVAEGKEGRHPAKAVSPEGDERFYRKHPESEFDRAHHHGGYGSTQAEKPSLPQKQSSLRNRKLHDMGCSLPEHRAHQEASHRQLCESKNGPPYPQGAGQLDYGSKGMPDTSEPSNYHNSGKYMTSGQGSLTLNHKEVRLPKDLDRPRARQPPGPEKHSRDCYKEEEHFSQSMVPPPKPERSHSLKLHHTQNLERDPSVLYQYQTHSKRQSSMTVVSQYDNLEDYHSLPQHQRGGFGGAGMGAYVPSGFVHPQSRTYATALGQGAFLPTELSLPHPDTQIHAE
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity. {ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:16716191, ECO:0000269|PubMed:17272280}.
uniprot
proteins
mass_dalton
229719
uniprot
proteins
mutagenesis
MUTAGEN 58; /note="R->K: Does not affect RhoA or CDC42 activity."; /evidence="ECO:0000269|PubMed:17272280
uniprot
proteins
post_translational_modification
PTM: Isoform 2 is phosphorylated on multiple tyrosine residues by FYN (By similarity). Phosphorylated tyrosine residues undergo dephosphorylation after stimulation of NMDA receptors. Phosphorylated in vitro by CaMK2 in the presence of calmodulin and calcium; which inhibits GAP activity. {ECO:0000250}.
uniprot
proteins
protein_family
PX domain-containing GAP family
uniprot
proteins
pubmed
12454018
uniprot
proteins
pubmed
12531901
uniprot
proteins
pubmed
12819203
uniprot
proteins
pubmed
12857875
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
16716191
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17272280
uniprot
proteins
pubmed
17663722
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
27609886
uniprot
proteins
sequence_length
2089
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic density {ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:27609886}. Cell projection, dendritic spine {ECO:0000269|PubMed:12531901}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:A7KAX9}. Endosome membrane {ECO:0000269|PubMed:17663722}. Golgi apparatus membrane {ECO:0000269|PubMed:17663722}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17663722}. Membrane {ECO:0000250|UniProtKB:A7KAX9}. Note=Association to membrane via PX domain (By similarity). Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic spine and postsynaptic density after differentiation (PubMed:12531901). Colocalizes with EGFR at the cell membrane upon EGF treatment (By similarity). Colocalizes with GAB2 at the cell membrane (By similarity). {ECO:0000250|UniProtKB:A7KAX9, ECO:0000269|PubMed:12531901}.
uniprot
proteins