Cul5
entrez
64624
canonical
uniprot
Q9JJ31
canonical
ensembl
ENSRNOG00000008039
resolver
ensp
ENSRNOP00000010956
resolver
ensp
ENSRNOP00000097338
resolver
enst
ENSRNOT00000114900
resolver
genesymbol
Cul5
resolver
genesymbol_syn
Vacm1
resolver
uniprot
A0A8I6ASH3
resolver
uniprot_entry
A0A8I6ASH3_RAT
resolver
uniprot_entry
CUL5_RAT
resolver
amino_acid_sequence
MATSNLLKNKGSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGSSKIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEVTLLGKQSSNKKSNMEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPGGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYDPQVNSPKDFTEGTLFSVNQDFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDEADINTFIYMA
uniprot
proteins
function
FUNCTION: Core component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes, also named CRL5 complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Acts a scaffold protein that contributes to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable SOCS box-containing substrate recognition component (By similarity). Acts as a key regulator of neuron positioning during cortex development: component of various SOCS-containing ECS complexes, such as the ECS(SOCS7) complex, that regulate reelin signaling by mediating ubiquitination and degradation of DAB1 (By similarity). ECS(SOCS1) seems to direct ubiquitination of JAK2. The ECS(SOCS2) complex mediates the ubiquitination and subsequent proteasomal degradation of phosphorylated EPOR and GHR. The ECS(SPSB3) complex catalyzes ubiquitination of nuclear CGAS. ECS(KLHDC1) complex is part of the DesCEND (destruction via C-end degrons) pathway and mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine. The ECS(ASB9) complex mediates ubiquitination and degradation of CKB. As part of some ECS complex, promotes 'Lys-11'-linked ubiquitination and degradation of BTRC. As part of a multisubunit ECS complex, polyubiquitinates monoubiquitinated POLR2A. As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration. As part of the ECS(RAB40A) complex, mediates RHOU 'Lys-48'-linked ubiquitination and degradation, thus inhibiting focal adhesion disassembly during cell migration. As part of the ECS(RAB40B) complex, mediates LIMA1/EPLIN and RAP2 ubiquitination, thereby regulating actin cytoskeleton dynamics and stress fiber formation during cell migration. The ECS(ASB7) complex acts a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1. As part of the ECS(LRRC58) complex, mediates CDO1 ubiquitination and degradation, regulating cysteine catabolism. May form a cell surface vasopressin receptor (By similarity). {ECO:0000250|UniProtKB:Q93034, ECO:0000250|UniProtKB:Q9D5V5}.
uniprot
proteins
mass_dalton
90890
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q93034}.
uniprot
proteins
post_translational_modification
PTM: Neddylated; which enhances the ubiquitination activity of ECS complexes and prevents binding of the inhibitor CAND1. Deneddylated via its interaction with the COP9 signalosome (CSN). {ECO:0000250|UniProtKB:Q93034}.
uniprot
proteins
protein_family
Cullin family
uniprot
proteins
pubmed
10849213
uniprot
proteins
sequence_length
780
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q93034}. Note=Localizes to sites of DNA damage in a UBAP2 and UBAP2L-dependent manner. {ECO:0000250|UniProtKB:Q93034}.
uniprot
proteins