Dusp29
entrez
435391
canonical
uniprot
Q8BK84
canonical
ensembl
ENSMUSG00000063821
resolver
ensp
ENSMUSP00000073534
resolver
ensp
ENSMUSP00000192490
resolver
enst
ENSMUST00000073870
resolver
genesymbol
Dusp29
resolver
genesymbol_syn
Dupd1
resolver
genesymbol_syn
Dusp27
resolver
uniprot
B2RW26
resolver
uniprot_entry
DUS29_MOUSE
resolver
uniprot_sec
B2RW26
resolver
amino_acid_sequence
MASGDTKTSVKHAHLCAERLSVREEEGDAEDYCTPGAFELERLFWKGSPQYTHVNEVWPRLHIGDEATALDRYGLQKAGFTHVLNAAHGRWNVDTGPDYYRDMAIEYHGVEADDVPTFDLSIFFYSAAAFIDSALRDDHSKILVHCAMGRSRSATLVLAYLMIHKNMTLVDAIQQVAKNRCVLPNRGFLKQLRELDKQLVKQRRQAGPGDSDLGL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of intracellular signaling cascades. In skeletal muscle regulates systemic glucose homeostasis by activating, AMPK, an energy sensor protein kinase (PubMed:30201684). Affects MAP kinase signaling though modulation of the MAPK1/2 cascade in skeletal muscle promoting muscle cell differentiation, development and atrophy (PubMed:32639872). {ECO:0000250|UniProtKB:Q68J44, ECO:0000269|PubMed:30201684, ECO:0000269|PubMed:32639872}.
uniprot
proteins
mass_dalton
24192
uniprot
proteins
mutagenesis
MUTAGEN 146; /note="C->S: Does not affect AMPK activity."; /evidence="ECO:0000269|PubMed:30201684
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17498703
uniprot
proteins
pubmed
30201684
uniprot
proteins
pubmed
32639872
uniprot
proteins
sequence_length
215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30201684, ECO:0000269|PubMed:32639872}. Nucleus {ECO:0000269|PubMed:32639872}.
uniprot
proteins