NAA40
entrez
79829
canonical
uniprot
Q86UY6
canonical
ensembl
ENSG00000110583
resolver
ensp
ENSP00000367024
resolver
ensp
ENSP00000442055
resolver
ensp
ENSP00000531981
resolver
genesymbol
NAA40
resolver
genesymbol_syn
NAT11
resolver
genesymbol_syn
PATT1
resolver
hgnc
HGNC:25845
resolver
uniprot
B4DR03
resolver
uniprot
B4DU10
resolver
uniprot
Q5HYL5
resolver
uniprot
Q9H897
resolver
uniprot_entry
NAA40_HUMAN
resolver
uniprot_sec
B4DR03
resolver
uniprot_sec
B4DU10
resolver
uniprot_sec
Q5HYL5
resolver
uniprot_sec
Q9H897
resolver
amino_acid_sequence
MGRKSSKAKEKKQKRLEERAAMDAVCAKVDAANRLGDPLEAFPVFKKYDRNGLNVSIECKRVSGLEPATVDWAFDLTKTNMQTMYEQSEWGWKDREKREEMTDDRAWYLIAWENSSVPVAFSHFRFDVECGDEVLYCYEVQLESKVRRKGLGKFLIQILQLMANSTQMKKVMLTVFKHNHGAYQFFREALQFEIDDSSPSMSGCCGEDCSYEILSRRTKFGDSHHSHAGGHCGGCCH
uniprot
proteins
ec_number
2.3.1.257
uniprot
proteins
function
FUNCTION: N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (PubMed:21935442, PubMed:25619998). In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence' (PubMed:21935442, PubMed:25619998). Acts as a negative regulator of apoptosis (PubMed:26666750). May play a role in hepatic lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q8VE10, ECO:0000269|PubMed:21935442, ECO:0000269|PubMed:25619998, ECO:0000269|PubMed:26666750}.
uniprot
proteins
mass_dalton
27194
uniprot
proteins
mutagenesis
MUTAGEN 85; /note="Y->A: Strongly reduced N-alpha-acetyltransferase activity."; /evidence="ECO:0000269|PubMed:25619998"; MUTAGEN 90; /note="W->A: Strongly reduced N-alpha-acetyltransferase activity."; /evidence="ECO:0000269|PubMed:25619998"; MUTAGEN 100; /note="E->A: 5 times reduced N-alpha-acetyltransferase activity."; /evidence="ECO:0000269|PubMed:25619998"; MUTAGEN 127..129; /note="DVE->AVA: Strongly reduced N-alpha-acetyltransferase activity."; /evidence="ECO:0000269|PubMed:25619998"; MUTAGEN 136; /note="Y->A: Strongly reduced N-alpha-acetyltransferase activity."; /evidence="ECO:0000269|PubMed:25619998"; MUTAGEN 136; /note="Y->F: Slightly reduced N-alpha-acetyltransferase activity."; /evidence="ECO:0000269|PubMed:19695338, ECO:0000269|PubMed:25619998"; MUTAGEN 137; /note="C->A: Reduced N-alpha-acetyltransferase activity."; /evidence="ECO:0000269|PubMed:25619998"; MUTAGEN 138; /note="Y->A: Strongly reduced N-alpha-acetyltransferase activity."; /evidence="ECO:0000269|PubMed:25619998"; MUTAGEN 139; /note="E->Q: Abolished N-alpha-acetyltransferase activity."; /evidence="ECO:0000269|PubMed:19695338, ECO:0000269|PubMed:25619998"; MUTAGEN 174; /note="T->A: Does not affect N-alpha-acetyltransferase activity."; /evidence="ECO:0000269|PubMed:25619998"; MUTAGEN 211; /note="Y->A: Does not affect N-alpha-acetyltransferase activity."; /evidence="ECO:0000269|PubMed:25619998
uniprot
proteins
protein_family
Acetyltransferase family
uniprot
proteins
protein_family
NAA40 subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19660095
uniprot
proteins
pubmed
19695338
uniprot
proteins
pubmed
21935442
uniprot
proteins
pubmed
24248912
uniprot
proteins
pubmed
25619998
uniprot
proteins
pubmed
25732826
uniprot
proteins
pubmed
26666750
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25732826}. Nucleus {ECO:0000269|PubMed:25732826}.
uniprot
proteins