RRAS
entrez
6237
canonical
uniprot
P10301
canonical
ensembl
ENSG00000126458
resolver
ensp
ENSP00000246792
resolver
enst
ENST00000246792
resolver
genesymbol
RRAS
resolver
hgnc
HGNC:10447
resolver
uniprot
Q6FH12
resolver
uniprot_entry
RRAS_HUMAN
resolver
uniprot_sec
Q6FH12
resolver
amino_acid_sequence
MSSGAASGTGRGRPRGGGPGPGDPPPSETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDPTIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGHGFLLVFAINDRQSFNEVGKLFTQILRVKDRDDFPVVLVGNKADLESQRQVPRSEASAFGASHHVAYFEASAKLRLNVDEAFEQLVRAVRKYQEQELPPSPPSAPRKKGGGCPCVLL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: GTP-binding protein with GTPase activity, likely involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (PubMed:39809765). Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267). {ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:39809765}.
uniprot
proteins
mass_dalton
23480
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="G->V: No effect on interaction with OSBPL3."; /evidence="ECO:0000269|PubMed:18270267"; MUTAGEN 43; /note="S->N: No effect on interaction with OSBPL3."; /evidence="ECO:0000269|PubMed:18270267
uniprot
proteins
post_translational_modification
PTM: S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability. {ECO:0000269|PubMed:20074548}.
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15242332
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16537651
uniprot
proteins
pubmed
16773572
uniprot
proteins
pubmed
18270267
uniprot
proteins
pubmed
20074548
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
3098437
uniprot
proteins
pubmed
39809765
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
uniprot
proteins