Hint1
entrez
690660
canonical
uniprot
P62959
canonical
ensembl
ENSRNOG00000086472
resolver
ensembl
ENSRNOG00055029100
resolver
ensembl
ENSRNOG00060027623
resolver
ensembl
ENSRNOG00065006211
resolver
ensp
ENSRNOP00000102416
resolver
ensp
ENSRNOP00055041475
resolver
ensp
ENSRNOP00060039880
resolver
ensp
ENSRNOP00065006791
resolver
enst
ENSRNOT00000165419
resolver
enst
ENSRNOT00055050389
resolver
enst
ENSRNOT00060047936
resolver
enst
ENSRNOT00065009476
resolver
genesymbol
Hint1
resolver
genesymbol_syn
Hint
resolver
genesymbol_syn
Pkci1
resolver
uniprot
B5DEM9
resolver
uniprot
P16436
resolver
uniprot_entry
HINT1_RAT
resolver
uniprot_sec
B5DEM9
resolver
uniprot_sec
P16436
resolver
amino_acid_sequence
MADEIAKAQVAQPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVADDDDESLLGHLMIVGKKCAADLGLKRGYRMVVNEGADGGQSVYHIHLHVLGGRQMNWPPG
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
ec_number
3.9.1.-
uniprot
proteins
function
FUNCTION: Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate) (By similarity). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester (By similarity). Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide (By similarity). In addition, functions as a scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 (By similarity). Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RANGAP1 and RGS17 (By similarity). {ECO:0000250|UniProtKB:P49773, ECO:0000250|UniProtKB:P70349}.
uniprot
proteins
mass_dalton
13777
uniprot
proteins
post_translational_modification
PTM: Deubiquitinated by USP40, leading to stabilization. {ECO:0000250|UniProtKB:P70349}.
uniprot
proteins
protein_family
HINT family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
126
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P49773}. Nucleus {ECO:0000250|UniProtKB:P49773}.
uniprot
proteins