Nup62
entrez
18226
canonical
uniprot
Q63850
canonical
ensembl
ENSMUSG00000109511
resolver
ensp
ENSMUSP00000056785
resolver
ensp
ENSMUSP00000146695
resolver
ensp
ENSMUSP00000147181
resolver
enst
ENSMUST00000057195
resolver
enst
ENSMUST00000207103
resolver
enst
ENSMUST00000208626
resolver
genesymbol
Nup62
resolver
uniprot
Q5FWJ9
resolver
uniprot
Q99JN7
resolver
uniprot_entry
NUP62_MOUSE
resolver
uniprot_entry
Q5FWJ9_MOUSE
resolver
uniprot_sec
Q99JN7
resolver
amino_acid_sequence
MSGFNFGGTGAPAGGFTFGTAKTATTTPATGFSFSASGTGTGGFNFGTPSQPAATTPSTSLFSLTTQTPTTQTPGFNFGTTPASGGTGFSLGISTPKLSLSNAAATPATANTGSFGLGSSTLTNAISSGSTSNQGTAPTGFVFGSSTTSAPSTGSTGFSFTSGSASQPGASGFSLGSVGSSAQPTALSGSPFTPATLVTTTAGATQPAAAAPTAATTSAGSTLFASIAAAPASSSATGLSLPAPVTTAATPSAGTLGFSLKAPGAAPGASTTSTTTTTTTTTTTAAAAAASTTTTGFALSLKPLVSAGPSSVAATALPASSTAAGTATGPAMTYAQLESLINKWSLELEDQERHFLQQATQVNAWDRTLIENGEKITSLHREVEKVKLDQKRLDQELDFILSQQKELEDLLSPLEESVKEQSGTIYLQHADEEREKTYKLAENIDAQLKRMAQDLKDIIEHLNMAGGPADTSDPLQQICKILNAHMDSLQWVDQSSALLQRRVEEASRVCEGRRKEQERSLRIAFD
uniprot
proteins
function
FUNCTION: Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown. {ECO:0000250|UniProtKB:P37198}.
uniprot
proteins
mass_dalton
53255
uniprot
proteins
mutagenesis
MUTAGEN 479; /note="C->S: Loss of reduction of influx rate of NLS cargo upon oxidative stress; when associated with S-509."; /evidence="ECO:0000269|PubMed:23641069"; MUTAGEN 510; /note="C->S: Loss of reduction of influx rate of NLS cargo upon oxidative stress; when associated with S-478."; /evidence="ECO:0000269|PubMed:23641069
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000303|PubMed:1915419}.; PTM: The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC.
uniprot
proteins
protein_family
Nucleoporin NSP1/NUP62 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
1915419
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23641069
uniprot
proteins
sequence_length
526
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P37198}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P37198}. Nucleus envelope {ECO:0000250|UniProtKB:P37198}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P37198}. Note=Central region of the nuclear pore, within the transporter. During mitotic cell division, it associates with the poles of the mitotic spindle. {ECO:0000250|UniProtKB:P37198}.
uniprot
proteins