Cacna1i
entrez
56827
canonical
uniprot
Q9Z0Y8
canonical
ensembl
ENSRNOG00000060407
resolver
ensp
ENSRNOP00000080577
resolver
enst
ENSRNOT00000092608
resolver
genesymbol
Cacna1i
resolver
uniprot
A0A8I5ZQK3
resolver
uniprot
Q9EQ59
resolver
uniprot_entry
A0A8I5ZQK3_RAT
resolver
uniprot_entry
CAC1I_RAT
resolver
uniprot_sec
Q9EQ59
resolver
amino_acid_sequence
MADSNLPPSSAAAPAPEPGITEQPGPRSPPPSPPGLEEPLEGTNPDVPHPDLAPVAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMECLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLTGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGNANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQNRRQAMGPGTPAPAKPGPHAKEPSHCKLCPRHSPLDPTPHTLVQPISAILASDPSSCPHCQHEAGRRPSGLGSTDSGQEGSGSGGSAEAEANGDGPQSSEDGVSSDLGKEEEQEDGAARLCGDVWRETREKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTTPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNLEEFDKLPEGLDNSRDLKLCPIPMTPNGHLDPSLPLGAHLGPAGTMGTAPRLSLQPDPVLVALDSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSGTWASRRSSWNSLKHKPPSAEHESLLSGEGGGSCVRACEGAREEAPTRTAPLHAPHAHHAHHGPHLAHRHRHHRRTLSLDTRDSVDLGELVPVVGAHSRAAWRGAGQAPGHEDCNGRMPNIAKDVFTKMDDCRDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENKFRILCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCVAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCPTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAEIELEMAHGLGPCPGPCPGPCPCPWPLAPVLARGCPLVLLGATGARIGRGRCWRRHRESPVPSTRYSPAQETLWLDSVSLIIKDSLEGELTIIDNLSGSVFHHYASPDGCGKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPVQSWLKHDSSQAPPSPFSPDGSSPLLQMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPSVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPVQVPGPRASLSPATRRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCLPPTLPPPGLTPARKFNSTSSLAAGPGRPGSTVSARGLVRSPSWAADRSKDPPGQAQLVSGLGSSAPGPQPPPGESTDAASKRKR
uniprot
proteins
function
FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H. {ECO:0000269|PubMed:11073957}.; FUNCTION: [Isoform 2]: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. {ECO:0000269|PubMed:10066244}.
uniprot
proteins
mass_dalton
243693
uniprot
proteins
post_translational_modification
PTM: In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II. {ECO:0000250}.
uniprot
proteins
protein_family
CACNA1I subfamily
uniprot
proteins
protein_family
Calcium channel alpha-1 subunit (TC 1.A.1.11) family
uniprot
proteins
pubmed
10066244
uniprot
proteins
pubmed
11073957
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
2201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 77..97; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 116..137; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 147..166; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 172..189; /note="Helical; Name=S4 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 210..230; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 372..396; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 599..619; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 633..654; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 661..679; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 688..711; /note="Helical; Name=S4 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 723..743; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 796..820; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 1126..1148; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1167..1187; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1198..1217; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1232..1253; /note="Helical; Name=S4 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1264..1287; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1365..1390; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1446..1466; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1481..1502; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1510..1528; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1543..1566; /note="Helical; Name=S4 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1581..1601; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1665..1692; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000255
uniprot
proteins