ST3GAL2
entrez
6483
canonical
uniprot
Q16842
canonical
ensembl
ENSG00000157350
resolver
ensp
ENSP00000345477
resolver
ensp
ENSP00000377257
resolver
ensp
ENSP00000529634
resolver
ensp
ENSP00000529635
resolver
ensp
ENSP00000529636
resolver
ensp
ENSP00000603996
resolver
ensp
ENSP00000603997
resolver
ensp
ENSP00000603998
resolver
ensp
ENSP00000603999
resolver
ensp
ENSP00000616033
resolver
ensp
ENSP00000616034
resolver
ensp
ENSP00000616036
resolver
ensp
ENSP00000616037
resolver
ensp
ENSP00000616038
resolver
ensp
ENSP00000616039
resolver
enst
ENST00000342907
resolver
enst
ENST00000393640
resolver
enst
ENST00000859575
resolver
enst
ENST00000859576
resolver
enst
ENST00000859577
resolver
enst
ENST00000933937
resolver
enst
ENST00000933938
resolver
enst
ENST00000933939
resolver
enst
ENST00000933940
resolver
enst
ENST00000945974
resolver
enst
ENST00000945975
resolver
enst
ENST00000945977
resolver
enst
ENST00000945978
resolver
enst
ENST00000945979
resolver
enst
ENST00000945980
resolver
genesymbol
ST3GAL2
resolver
genesymbol_syn
SIAT4B
resolver
hgnc
HGNC:10863
resolver
uniprot
B3KXG9
resolver
uniprot
O00654
resolver
uniprot_entry
B3KXG9_HUMAN
resolver
uniprot_entry
SIA4B_HUMAN
resolver
uniprot_sec
O00654
resolver
amino_acid_sequence
MKCSLRVWFLSVAFLLVFIMSLLFTYSHHSMATLPYLDSGALDGTHRVKLVPGYAGLQRLSKERLSGKSCACRRCMGDAGASDWFDSHFDGNISPVWTRENMDLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLVPFKVLDLLWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYRGN
uniprot
proteins
ec_number
2.4.3.2
uniprot
proteins
ec_number
2.4.3.4
uniprot
proteins
function
FUNCTION: A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8920913, PubMed:9266697). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:25916169, PubMed:8920913, PubMed:9266697). Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8920913, PubMed:9266697). Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity). Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (By similarity). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (PubMed:12716912). Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:25916169, PubMed:9266697). {ECO:0000250|UniProtKB:Q11204, ECO:0000269|PubMed:12716912, ECO:0000269|PubMed:25916169, ECO:0000269|PubMed:8920913, ECO:0000269|PubMed:9266697}.
uniprot
proteins
mass_dalton
40173
uniprot
proteins
mutagenesis
MUTAGEN 92; /note="N->Q: Has a moderate effect on N-glycosylation and sialyltransferase activity; when associated with Q-211."; /evidence="ECO:0000269|PubMed:25916169"; MUTAGEN 211; /note="N->Q: Impairs N-glycosylation. Impairs exit from the endoplasmic reticulum. Decreases sialyltransferase activity."; /evidence="ECO:0000269|PubMed:25916169
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000305|PubMed:9266697}.; PATHWAY: Glycolipid biosynthesis. {ECO:0000305|PubMed:9266697}.
uniprot
proteins
post_translational_modification
PTM: The soluble form derives from the membrane form by proteolytic processing. {ECO:0000250}.; PTM: N-glycosylated; necessary for proper exit from endoplasmic reticulum and trafficking to the Golgi apparatus. {ECO:0000269|PubMed:25916169}.
uniprot
proteins
protein_family
Glycosyltransferase 29 family
uniprot
proteins
pubmed
12716912
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25916169
uniprot
proteins
pubmed
8920913
uniprot
proteins
pubmed
9266697
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:25916169}; Single-pass type II membrane protein {ECO:0000255}. Secreted {ECO:0000250}. Note=Membrane-bound form distributed along the Golgi cisternae, mainly in proximal compartments (PubMed:25916169). Secreted into the body fluid. {ECO:0000250, ECO:0000269|PubMed:25916169}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins