TAB2
entrez
23118
canonical
uniprot
Q9NYJ8
canonical
ensembl
ENSG00000055208
resolver
ensp
ENSP00000356426
resolver
ensp
ENSP00000490618
resolver
ensp
ENSP00000564658
resolver
ensp
ENSP00000564660
resolver
ensp
ENSP00000564661
resolver
ensp
ENSP00000589190
resolver
genesymbol
TAB2
resolver
genesymbol_syn
KIAA0733
resolver
genesymbol_syn
MAP3K7IP2
resolver
hgnc
HGNC:17075
resolver
uniprot
B2RCC4
resolver
uniprot
B4DIR9
resolver
uniprot
E1P5A0
resolver
uniprot
O94838
resolver
uniprot
Q6I9W8
resolver
uniprot
Q76N06
resolver
uniprot
Q9UFP7
resolver
uniprot_entry
B4DIR9_HUMAN
resolver
uniprot_entry
TAB2_HUMAN
resolver
uniprot_sec
B2RCC4
resolver
uniprot_sec
E1P5A0
resolver
uniprot_sec
O94838
resolver
uniprot_sec
Q6I9W8
resolver
uniprot_sec
Q76N06
resolver
uniprot_sec
Q9UFP7
resolver
amino_acid_sequence
MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSELFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVTLAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTLNRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDTEDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF
uniprot
proteins
disease_involvement
DISEASE: Congenital heart defects, multiple types, 2 (CHTD2) [MIM:614980]: A disease characterized by congenital developmental abnormalities involving structures of the heart. CHTD2 patients have left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation. {ECO:0000269|PubMed:20493459}. Note=The disease is caused by variants affecting the gene represented in this entry. A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25).
uniprot
proteins
function
FUNCTION: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020, PubMed:33184450, PubMed:36681779). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020). The RanBP2-type zinc finger (NZF) specifically recognizes 'Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed:20493459). {ECO:0000250|UniProtKB:Q99K90, ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:20493459, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:33184450, ECO:0000269|PubMed:36681779}.
uniprot
proteins
mass_dalton
76494
uniprot
proteins
mutagenesis
MUTAGEN 329; /note="K->R: Loss of TRIM60-mediated SUMOylation; when associated with R-562."; /evidence="ECO:0000269|PubMed:33184450"; MUTAGEN 562; /note="K->R: Loss of TRIM60-mediated SUMOylation; when associated with R-329."; /evidence="ECO:0000269|PubMed:33184450"; MUTAGEN 611; /note="K->R: Loss of TRIM35-mediated ubiquitination."; /evidence="ECO:0000269|PubMed:36681779"; MUTAGEN 670; /note="C->S: Disrupted zinc-finger; abolished methylation at C-673."; /evidence="ECO:0000269|PubMed:22158122"; MUTAGEN 673; /note="C->L,M: Abolished Cys methylation and ability to bind 'Lys-63'-linked ubiquitin."; /evidence="ECO:0000269|PubMed:22158122"; MUTAGEN 675; /note="F->A: Abolishes ubiquitin binding."; /evidence="ECO:0000269|PubMed:19935683"; MUTAGEN 678; /note="H->A: Abolishes ubiquitin binding."; /evidence="ECO:0000269|PubMed:19935683"; MUTAGEN 681; /note="L->A: Abolishes ubiquitin binding."; /evidence="ECO:0000269|PubMed:19935683"; MUTAGEN 684; /note="C->S: Disrupted zinc-finger; abolished methylation at C-673."; /evidence="ECO:0000269|PubMed:22158122"; MUTAGEN 685; /note="E->A: Abolishes ubiquitin binding."; /evidence="ECO:0000269|PubMed:19935683"; MUTAGEN 687; /note="C->S: Disrupted zinc-finger; abolished methylation at C-673."; /evidence="ECO:0000269|PubMed:22158122
uniprot
proteins
post_translational_modification
PTM: Degraded in a lysosome-dependent manner following interaction with TRIM38. {ECO:0000269|PubMed:24434549}.; PTM: SUMOylated by TRIM60; leading to inhibition of MAPK/NF-kappaB activation and the innate immune response. {ECO:0000269|PubMed:33184450}.; PTM: Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation. Ubiquitinated at Lys-611 by TRIM45 leading to proteasomal degradation (PubMed:36681779). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:17449468, ECO:0000269|PubMed:36681779}.; PTM: Phosphorylated. {ECO:0000305|PubMed:10882101}.; PTM: (Microbial infection) Methylated at Cys-673 by enteropathogenic E.coli protein NleE or S.flexneri protein OspZ: methylation disrupts zinc-binding and ability to bind 'Lys-63'-linked ubiquitin, leading to NF-kappa-B inactivation. {ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:25412445, ECO:0000269|PubMed:27445336}.
uniprot
proteins
pubmed
10882101
uniprot
proteins
pubmed
11460167
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14633987
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15327770
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17449468
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18079694
uniprot
proteins
pubmed
18299187
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19521662
uniprot
proteins
pubmed
19675569
uniprot
proteins
pubmed
19935683
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20493459
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21512573
uniprot
proteins
pubmed
22158122
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24434549
uniprot
proteins
pubmed
25412445
uniprot
proteins
pubmed
27426733
uniprot
proteins
pubmed
27445336
uniprot
proteins
pubmed
27746020
uniprot
proteins
pubmed
33184450
uniprot
proteins
pubmed
33431678
uniprot
proteins
pubmed
36681779
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
693
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:24434549}; Peripheral membrane protein {ECO:0000269|PubMed:10882101}. Endosome membrane {ECO:0000269|PubMed:24434549}; Peripheral membrane protein {ECO:0000269|PubMed:10882101}. Lysosome membrane {ECO:0000269|PubMed:24434549}; Peripheral membrane protein {ECO:0000269|PubMed:10882101}. Cytoplasm, cytosol {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:24434549, ECO:0000269|PubMed:36681779}. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol (PubMed:10882101). Interaction with TRIM38 promotes translocation from cytosol to endosome and lysosome (PubMed:24434549). {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:24434549}.
uniprot
proteins