TM7SF3
entrez
51768
canonical
uniprot
Q9NS93
canonical
ensembl
ENSG00000064115
resolver
ensp
ENSP00000342322
resolver
ensp
ENSP00000538021
resolver
ensp
ENSP00000538023
resolver
ensp
ENSP00000654165
resolver
ensp
ENSP00000654168
resolver
ensp
ENSP00000654172
resolver
ensp
ENSP00000693010
resolver
ensp
ENSP00000785039
resolver
enst
ENST00000343028
resolver
genesymbol
TM7SF3
resolver
hgnc
HGNC:23049
resolver
uniprot
B3KMZ3
resolver
uniprot
Q9NUS4
resolver
uniprot_entry
TM7S3_HUMAN
resolver
uniprot_sec
B3KMZ3
resolver
uniprot_sec
Q9NUS4
resolver
amino_acid_sequence
MGFLQLLVVAVLASEHRVAGAAEVFGNSSEGLIEFSVGKFRYFELNRPFPEEAILHDISSNVTFLIFQIHSQYQNTTVSFSPTLLSNSSETGTASGLVFILRPEQSTCTWYLGTSGIQPVQNMAILLSYSERDPVPGGCNLEFDLDIDPNIYLEYNFFETTIKFAPANLGYARGVDPPPCDAGTDQDSRWRLQYDVYQYFLPENDLTEEMLLKHLQRMVSVPQVKASALKVVTLTANDKTSVSFSSLPGQGVIYNVIVWDPFLNTSAAYIPAHTYACSFEAGEGSCASLGRVSSKVFFTLFALLGFFICFFGHRFWKTELFFIGFIIMGFFFYILITRLTPIKYDVNLILTAVTGSVGGMFLVAVWWRFGILSICMLCVGLVLGFLISSVTFFTPLGNLKIFHDDGVFWVTFSCIAILIPVVFMGCLRILNILTCGVIGSYSVVLAIDSYWSTSLSYITLNVLKRALNKDFHRAFTNVPFQTNDFIILAVWGMLAVSGITLQIRRERGRPFFPPHPYKLWKQERERRVTNILDPSYHIPPLRERLYGRLTQIKGLFQKEQPAGERTPLLL
uniprot
proteins
function
FUNCTION: Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623). {ECO:0000269|PubMed:21853325, ECO:0000269|PubMed:27740623}.
uniprot
proteins
mass_dalton
64166
uniprot
proteins
pubmed
10828615
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21853325
uniprot
proteins
pubmed
27740623
uniprot
proteins
sequence_length
570
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10828615}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 296..313; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 320..342; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 347..369; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 371..393; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 408..430; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 437..459; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 479..501; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins