Khdrbs3
entrez
64015
canonical
uniprot
Q9JLP1
canonical
ensembl
ENSRNOG00000009539
resolver
ensp
ENSRNOP00000012753
resolver
ensp
ENSRNOP00000076402
resolver
enst
ENSRNOT00000112404
resolver
genesymbol
Khdrbs3
resolver
genesymbol_syn
Slm2
resolver
uniprot
A0A8I5YBJ1
resolver
uniprot_entry
A0A8I5YBJ1_RAT
resolver
uniprot_entry
KHDR3_RAT
resolver
amino_acid_sequence
MEEKYLPELMAEKDSLDPSFTHALRLVNREIEKFQKGEAKDEEKYIDVVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDLHVLIEVFAPPAEAYARMGHALEDIKKFLIPDYNDEIRQAQLQELTYLNGGSENADVPVVRGKSTLRTRGVTTPAITRGRGGVTARPVAVGVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPPPPPTQETYGEYDYDDGYSTAYDDQSYDSYDNSYSTPAQSGADYYDYGHGLGEEAYDSYGQEDWTNSRHKAPSARTAKGVYREQPYGRY
uniprot
proteins
function
FUNCTION: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion (PubMed:11118435). Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (By similarity). Involved in splice site selection of vascular endothelial growth factor. In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (PubMed:11118435). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members. Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity. May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing. Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation (By similarity). {ECO:0000250|UniProtKB:O75525, ECO:0000250|UniProtKB:Q9R226, ECO:0000269|PubMed:11118435}.
uniprot
proteins
mass_dalton
38779
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues. {ECO:0000250|UniProtKB:O75525, ECO:0000250|UniProtKB:Q9R226}.
uniprot
proteins
protein_family
KHDRBS family
uniprot
proteins
pubmed
10332027
uniprot
proteins
pubmed
11118435
uniprot
proteins
pubmed
15345239
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10332027}.
uniprot
proteins