Gpr45
entrez
93690
canonical
uniprot
Q9EQQ4
canonical
ensembl
ENSMUSG00000041907
resolver
ensp
ENSMUSP00000110409
resolver
ensp
ENSMUSP00000135986
resolver
enst
ENSMUST00000114761
resolver
enst
ENSMUST00000179766
resolver
genesymbol
Gpr45
resolver
uniprot
Q148B5
resolver
uniprot
Q8C6N9
resolver
uniprot
Q8CA29
resolver
uniprot_entry
GPR45_MOUSE
resolver
uniprot_entry
Q148B5_MOUSE
resolver
uniprot_entry
Q8C6N9_MOUSE
resolver
uniprot_entry
Q8CA29_MOUSE
resolver
amino_acid_sequence
MACNSTPMGTYEHLLLNVSNTLDPGDTPLSAPLRISLAIMMLLMIVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCMPFTAITLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQRQDKLNPRRAKMIIAASWVLSFCISAPSFTGWTFMEVPARAPQCVLGYTEFPAERAYVVTLVVAVFFAPFGVMLCSYLCILNTVRKNAVRVHNQSDSLDLRQLTGAGLRRLRRQQQQASLDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSAFSRRFYYSASFYTTSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELLPHTFQILPKVPERIQRKIQPSTIYVCNENQSAV
uniprot
proteins
function
FUNCTION: Protein carrier that acts as a regulator of food intake in the paraventricular nucleus of the hypothalamus (PVH) by mediating transport of G(s) into primary cilia (PubMed:40472089). Transported into primary cilia of PVH neurons via its association with TULP3 and carries G(s) into the primary cilia to support MC4R activity and activate ADCY3, leading to cAMP production, which signals to suppress appetite (PubMed:40472089). Does not act as a canonical G protein-coupled receptor: does not promote the exchange of GDP for GTP on G(s) protein but mediates G(s) translocation into primary cilia (PubMed:40472089). {ECO:0000269|PubMed:40472089}.
uniprot
proteins
mass_dalton
42358
uniprot
proteins
mutagenesis
MUTAGEN 214; /note="S->P: In the expansive mutant; obesity due to hyperphagia."; /evidence="ECO:0000269|PubMed:40472089"; MUTAGEN 287; /note="Y->C: In the extensive mutant; obesity due to hyperphagia."; /evidence="ECO:0000269|PubMed:40472089
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11027574
uniprot
proteins
pubmed
27500489
uniprot
proteins
pubmed
40449730
uniprot
proteins
pubmed
40472089
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:40472089}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000269|PubMed:40472089}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 76..96; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 199..219; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 270..290; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 307..327; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins