Trim38
entrez
214158
canonical
uniprot
Q5SZ99
canonical
ensembl
ENSMUSG00000064140
resolver
ensp
ENSMUSP00000073709
resolver
ensp
ENSMUSP00000153240
resolver
enst
ENSMUST00000074067
resolver
enst
ENSMUST00000226039
resolver
genesymbol
Trim38
resolver
uniprot
B9EKD3
resolver
uniprot_entry
TRI38_MOUSE
resolver
uniprot_sec
B9EKD3
resolver
amino_acid_sequence
MGSDFSTVKIRKVTSCSICKAMMSHPVSINCGHSYCKSCIQSYYCNVSPKTGWKMLGCPLCSSPFSLENLRPNKELETIIDMIKGMEEQDQDMVCEEHEEKFNRFCEDDGQLLCWRCYWEDRHKGHTLAHVKDVYQNYKEKLQNTMTKLRELQENHEVQIHFITHQINAWKDAVEDRRQTIKSNFKNLQSFLQEEEKFYLWRLENEEKEMLVQLEGSEANLQQTFERAQCQIQELEAKCQGSAQKLLQDVKNTLSRCEAMKRNPLKADPLKVHTKCNVSELYFDVKTILRRHQVSVILDPSTAHLDLALTKGGRLVTYKRCPRDLQARSSAKRFYGLPCVLGCEGFTSGRYYFEVSVENATSWDLGVCVENVHRGFNMKKEPESGFWTIKMSEEDGLEALTSTPTPPLHLIEKPQILGVFLDYEAGAVSFYSVTTGSHIFTFPKASFQDTLRPFFQVYQYSPLFLPAINNQ
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:22539786, PubMed:26392463, PubMed:27637147). Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (PubMed:22539786). Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:26392463). Acts as a positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (PubMed:27637147). Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (By similarity). {ECO:0000250|UniProtKB:O00635, ECO:0000269|PubMed:22539786, ECO:0000269|PubMed:26392463, ECO:0000269|PubMed:27637147}.
uniprot
proteins
mass_dalton
54430
uniprot
proteins
mutagenesis
MUTAGEN 16; /note="C->A: Abolished E3 ubiquitin-protein activity and ability to inhibit type I interferon IFN-beta production."; /evidence="ECO:0000269|PubMed:22539786"; MUTAGEN 31; /note="C->S: Abolished E3 ubiquitin-protein activity and ability to ubiquitinate TICAM1. Abolished E3 SUMO-protein activity and ability to sumoylate CGAS."; /evidence="ECO:0000269|PubMed:26392463, ECO:0000269|PubMed:27637147
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:22539786, ECO:0000269|PubMed:26392463}.; PATHWAY: Protein modification; protein sumoylation. {ECO:0000269|PubMed:27637147}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22539786
uniprot
proteins
pubmed
26392463
uniprot
proteins
pubmed
27637147
uniprot
proteins
sequence_length
471
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22539786}.
uniprot
proteins