Ccp110
entrez
101565
canonical
uniprot
Q7TSH4
canonical
ensembl
ENSMUSG00000033904
resolver
ensp
ENSMUSP00000038881
resolver
ensp
ENSMUSP00000102167
resolver
ensp
ENSMUSP00000147070
resolver
ensp
ENSMUSP00000279213
resolver
ensp
ENSMUSP00000279214
resolver
enst
ENSMUST00000038650
resolver
enst
ENSMUST00000106557
resolver
genesymbol
Ccp110
resolver
genesymbol_syn
Cep110
resolver
genesymbol_syn
Cp110
resolver
genesymbol_syn
Kiaa0419
resolver
uniprot
Q6A072
resolver
uniprot_entry
CP110_MOUSE
resolver
uniprot_sec
Q6A072
resolver
amino_acid_sequence
MEEYEEFCEKALGRAQEASLSTGSFLPAQAESVSLIRFHGVAVLSPLLTIEKRKKIQEEKQKALDVQSRKQANRKKALLTRVQEILENVQVRKAPNASDFDQWATETIYSNPEVTDLNVPVRVPNSLPSPTEHCTSVKLEKITGLLPVNNEDQQTPKRVGLPGDSEVSGSLRQCESPESRQAEDGAALRLSSASPQETIISDVLGKEEQDPSCLAEVTPDPYIMSLQNLMKRSKEYVERELSSRSLRNSLKRSVNETHSDRENDAAKASDCVKEKAPPMPIGRHCGSAIPDKPSLNKSNVLLQGASQASSMGTAGLASFSKIDLPAGAAPPAAPDAGSDFTVIPTFVTENKVKSLKGPYAKLPSPEPSMSPTMHRRHSRSASACQILINNPVNACELSPKGKEEAVDRTAPAAAETTNESETVPKSPTDLTGVCSSNVSATKITSESTREMVVGKPSQRQQALGAHLGNNVTVERSAMEGPFIADDRGAQKVDGTCMAVPKLHELQPSSQCVSSQTLEDVCELKSASLLAKNSCNLQMELNKSYDVKHPSPLLTQTQTSRQQMDTPPVFRGNEQFVDNSFEKVKRRLDLDVDSLQKENCPYIITAGVAEQERDRLLERRYPKGFVHINKNKMLETSPKEGQELLKSKMLAFEEMRKRLEEQHAQQLSLLIAEQEREQEQLQKEIEEQEKMLKEKAVTTDVSDLNSALEWRQRTDSALLETMLSQVDSLQTSNNSGFITSALQYSFGSAGEAPFYLWGSLTSGVTRVSGTRPCGRAQAKWSQVFNPEIHAKFNKITAVAKGFLTRKLMQTDKLKQLRQTVKDTMEFIRSFQSEAPLKRGVVSAQDASLQERVLAQLRAALYGIHDIFFVMDAAERMSILHHDREARKEKLLRQMDKMKSPRVALSVATQKSLDRKKFMKVAEMGMPNKKFLLKQNPSETRVLQPNQGQNAPVHRLLSRQGTPKTSVKGVVQNRQKPSQSRVPNRAPVSGAYAGKTQRKRPNVATI
uniprot
proteins
function
FUNCTION: Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:23141541). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (PubMed:26965371). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (By similarity). {ECO:0000250|UniProtKB:O43303, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:26965371}.
uniprot
proteins
mass_dalton
111139
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDKs. {ECO:0000250|UniProtKB:O43303}.; PTM: Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Ubiquitinated by the EDVP complex, leading to its degradation. {ECO:0000250|UniProtKB:O43303}.
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23141541
uniprot
proteins
pubmed
23807208
uniprot
proteins
pubmed
26670998
uniprot
proteins
pubmed
26965371
uniprot
proteins
pubmed
30375385
uniprot
proteins
pubmed
35301795
uniprot
proteins
pubmed
39092789
uniprot
proteins
sequence_length
1004
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:O43303}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23807208, ECO:0000269|PubMed:30375385}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23807208}. Note=Recruited early and then associates with the growing distal tips (PubMed:23141541). Recruited to the mother centriole by KIF24 (By similarity). Removed from centrioles by TTBK2, leading to initiation of ciliogenesis and localizes only to the daughter centriole in ciliated cells (PubMed:23141541). In cytotoxic T lymphocytes remains associated with the mother centriole during docking of the centrosome at the immunological synapse upon target contact (PubMed:26670998). Recruited at the distal end of the mother centriole by MPHOSPH9 (By similarity). {ECO:0000250|UniProtKB:O43303, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:26670998}.
uniprot
proteins