Cd300lf
entrez
246746
canonical
uniprot
Q6SJQ7
canonical
ensembl
ENSMUSG00000047798
resolver
ensp
ENSMUSP00000053983
resolver
ensp
ENSMUSP00000102171
resolver
ensp
ENSMUSP00000102172
resolver
ensp
ENSMUSP00000240408
resolver
enst
ENSMUST00000106562
resolver
genesymbol
Cd300lf
resolver
genesymbol_syn
CLM-1
resolver
genesymbol_syn
Clm1
resolver
genesymbol_syn
Lmir3
resolver
uniprot
A0A1C9ZQ14
resolver
uniprot
A2A6Z1
resolver
uniprot
A2A6Z2
resolver
uniprot
A2A6Z3
resolver
uniprot
Q6PEU7
resolver
uniprot
Q8K4V9
resolver
uniprot_entry
A0A1C9ZQ14_MOUSE
resolver
uniprot_entry
A2A6Z2_MOUSE
resolver
uniprot_entry
CLM1_MOUSE
resolver
uniprot_sec
A2A6Z1
resolver
uniprot_sec
A2A6Z3
resolver
uniprot_sec
Q6PEU7
resolver
uniprot_sec
Q8K4V9
resolver
amino_acid_sequence
MHLSLLVPFLFWITGCCTAEDPVTGPEEVSGQEQGSLTVQCRYTSGWKDYKKYWCQGVPQRSCKTLVETDASEQLVKKNRVSIRDNQRDFIFTVTMEDLRMSDAGIYWCGITKGGLDPMFKVTVNIGPAIQVPITVPTMPPITSTTTIFTVTTTVKETSMFPTLTSYYSDNGHGGGDSGGGEDGVGDGFLDLSVLLPVISAVLLLLLLVASLFAWRMVRRQKKAAGPPSEQAQSLEGDLCYADLSLKQPRTSPGSSWKKGSSMSSSGKDHQEEVEYVTMAPFPREEVSYAALTLAGLGQEPTYGNTGCPITHVPRTGLEEETTEYSSIRRPLPAAMP
uniprot
proteins
function
FUNCTION: Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:17438331). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells (PubMed:21865548). Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (PubMed:26768664). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide which acts as a ligand (PubMed:23123064). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (PubMed:26124135). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (By similarity). Inhibits osteoclast formation (PubMed:14662855). Induces macrophage cell death upon engagement (PubMed:18097021). {ECO:0000250|UniProtKB:Q8TDQ1, ECO:0000269|PubMed:14662855, ECO:0000269|PubMed:17438331, ECO:0000269|PubMed:18097021, ECO:0000269|PubMed:21865548, ECO:0000269|PubMed:23123064, ECO:0000269|PubMed:26124135, ECO:0000269|PubMed:26768664}.; FUNCTION: (Microbial infection) Acts as a functional receptor for murine norovirus (MNV). Mediates binding to the cell surface and is both necessary and sufficient for viral entry and replication (PubMed:27540007, PubMed:27681626, PubMed:30194229). This interaction requires Mg(2+) and Ca(2+) and is enhanced by bile acids (PubMed:30194229). Primary determinant of MNV species tropism and is sufficient to render cells permissive to infection by MNV. Can render nonmurine mammalian cells susceptible to MNV infection (PubMed:27540007, PubMed:27681626). {ECO:0000269|PubMed:27540007, ECO:0000269|PubMed:27681626, ECO:0000269|PubMed:30194229}.
uniprot
proteins
mass_dalton
36715
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine. {ECO:0000269|PubMed:23123064}.
uniprot
proteins
protein_family
CD300 family
uniprot
proteins
pubmed
14662855
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17438331
uniprot
proteins
pubmed
18097021
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21865548
uniprot
proteins
pubmed
23123064
uniprot
proteins
pubmed
26124135
uniprot
proteins
pubmed
26768664
uniprot
proteins
pubmed
27540007
uniprot
proteins
pubmed
27681626
uniprot
proteins
pubmed
30194229
uniprot
proteins
sequence_length
337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 194..214; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins