NTRK2
entrez
4915
canonical
uniprot
Q16620
canonical
ensembl
ENSG00000148053
resolver
ensp
ENSP00000277120
resolver
ensp
ENSP00000306167
resolver
ensp
ENSP00000314586
resolver
ensp
ENSP00000352906
resolver
ensp
ENSP00000365381
resolver
ensp
ENSP00000365386
resolver
ensp
ENSP00000379221
resolver
ensp
ENSP00000508443
resolver
ensp
ENSP00000508497
resolver
ensp
ENSP00000508622
resolver
ensp
ENSP00000508829
resolver
ensp
ENSP00000508947
resolver
ensp
ENSP00000509020
resolver
ensp
ENSP00000509058
resolver
ensp
ENSP00000509145
resolver
ensp
ENSP00000509169
resolver
ensp
ENSP00000509743
resolver
ensp
ENSP00000510032
resolver
ensp
ENSP00000510060
resolver
ensp
ENSP00000510071
resolver
ensp
ENSP00000510134
resolver
ensp
ENSP00000510356
resolver
ensp
ENSP00000510451
resolver
ensp
ENSP00000510619
resolver
ensp
ENSP00000510640
resolver
ensp
ENSP00000510717
resolver
ensp
ENSP00000510766
resolver
ensp
ENSP00000554816
resolver
ensp
ENSP00000674670
resolver
enst
ENST00000323115
resolver
enst
ENST00000686542
resolver
enst
ENST00000689301
resolver
enst
ENST00000692473
resolver
genesymbol
NTRK2
resolver
genesymbol_syn
TRKB
resolver
hgnc
HGNC:8032
resolver
uniprot
A0A8I5KR47
resolver
uniprot
A0A8I5KUZ1
resolver
uniprot
A0A8I5KZB7
resolver
uniprot
A0A8J8YUT9
resolver
uniprot
B1ANZ4
resolver
uniprot
B4DFV9
resolver
uniprot
Q16675
resolver
uniprot
Q548C2
resolver
uniprot
Q59GJ1
resolver
uniprot
Q5VWE5
resolver
uniprot
Q8WXJ5
resolver
uniprot
Q8WXJ6
resolver
uniprot
Q8WXJ7
resolver
uniprot_entry
A0A8I5KR47_HUMAN
resolver
uniprot_entry
A0A8I5KUZ1_HUMAN
resolver
uniprot_entry
A0A8I5KZB7_HUMAN
resolver
uniprot_entry
A0A8J8YUT9_HUMAN
resolver
uniprot_entry
NTRK2_HUMAN
resolver
uniprot_entry
Q548C2_HUMAN
resolver
uniprot_entry
Q5VWE5_HUMAN
resolver
uniprot_sec
B1ANZ4
resolver
uniprot_sec
B4DFV9
resolver
uniprot_sec
Q16675
resolver
uniprot_sec
Q59GJ1
resolver
uniprot_sec
Q8WXJ5
resolver
uniprot_sec
Q8WXJ6
resolver
uniprot_sec
Q8WXJ7
resolver
activity_regulation
ACTIVITY REGULATION: The neuronal activity and the influx of calcium positively regulate the kinase activity and the internalization of the receptor which are both important for active signaling. Regulated by NGFR that may control the internalization of the receptor. NGFR may also stimulate the activation by BDNF compared to NTF3 and NTF4. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. The formation of active receptors dimers able to fully transduce the ligand-mediated signal, may be negatively regulated by the formation of inactive heterodimers with the non-catalytic isoforms (By similarity). {ECO:0000250|UniProtKB:P15209, ECO:0000250|UniProtKB:Q63604}.
uniprot
proteins
amino_acid_sequence
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
uniprot
proteins
disease_involvement
DISEASE: Developmental and epileptic encephalopathy 58 (DEE58) [MIM:617830]: A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE58 is an autosomal dominant condition characterized by onset of refractory seizures in the first days or months of life. {ECO:0000269|PubMed:29100083}. Note=The disease may be caused by variants affecting the gene represented in this entry.; DISEASE: Obesity, hyperphagia, and developmental delay (OBHD) [MIM:613886]: A disorder characterized by early-onset obesity, hyperphagia, and severe developmental delay in motor function, speech, and language. {ECO:0000269|PubMed:15494731, ECO:0000269|PubMed:27884935, ECO:0000269|PubMed:29100083}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:15494731, PubMed:7574684). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. {ECO:0000250|UniProtKB:P15209, ECO:0000269|PubMed:15494731, ECO:0000269|PubMed:7574684}.
uniprot
proteins
mass_dalton
91999
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Isoform TrkB-T-Shc is not phosphorylated. {ECO:0000269|PubMed:15494731}.; PTM: Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Insulin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10092678
uniprot
proteins
pubmed
10388563
uniprot
proteins
pubmed
11738045
uniprot
proteins
pubmed
11798182
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15494731
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18293376
uniprot
proteins
pubmed
20193039
uniprot
proteins
pubmed
27884935
uniprot
proteins
pubmed
29100083
uniprot
proteins
pubmed
35840571
uniprot
proteins
pubmed
7574684
uniprot
proteins
pubmed
7789988
uniprot
proteins
pubmed
7823156
uniprot
proteins
pubmed
7936202
uniprot
proteins
sequence_length
822
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15494731}; Single-pass type I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000250|UniProtKB:P15209}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P15209}. Early endosome membrane {ECO:0000250|UniProtKB:P15209}. Cell projection, axon {ECO:0000250|UniProtKB:Q63604}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63604}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q63604}. Postsynaptic density {ECO:0000250|UniProtKB:P15209}. Note=Internalized to endosomes upon ligand-binding. {ECO:0000250|UniProtKB:P15209}.
uniprot
proteins
transmembrane_region
TRANSMEM 431..454; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins