Stx4
entrez
20909
canonical
uniprot
P70452
canonical
ensembl
ENSMUSG00000030805
resolver
ensp
ENSMUSP00000033075
resolver
ensp
ENSMUSP00000112927
resolver
ensp
ENSMUSP00000346144
resolver
enst
ENSMUST00000033075
resolver
enst
ENSMUST00000121705
resolver
genesymbol
Stx4
resolver
genesymbol_syn
Stx4a
resolver
uniprot
Q3TSL5
resolver
uniprot
Q3UKQ8
resolver
uniprot
Q80WT8
resolver
uniprot_entry
STX4_MOUSE
resolver
uniprot_sec
Q3TSL5
resolver
uniprot_sec
Q3UKQ8
resolver
uniprot_sec
Q80WT8
resolver
amino_acid_sequence
MRDRTHELRQGDNISDDEDEVRVALVVHSGAARLGSPDDEFFQKVQTIRQTMAKLESKVRELEKQQVTILATPLPEESMKQGLQNLREEIKQLGREVRAQLKAIEPQKEEADENYNSVNTRMKKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHEIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKIALENQKKARKKKVMIAICVSVTVLILAVIIGITITVG
uniprot
proteins
function
FUNCTION: Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones. Required for normal hearing (By similarity). {ECO:0000250|UniProtKB:Q08850, ECO:0000250|UniProtKB:Q12846, ECO:0000269|PubMed:10394363, ECO:0000269|PubMed:18827011, ECO:0000269|PubMed:9045631}.
uniprot
proteins
mass_dalton
34165
uniprot
proteins
protein_family
Syntaxin family
uniprot
proteins
pubmed
10394363
uniprot
proteins
pubmed
11809830
uniprot
proteins
pubmed
12877659
uniprot
proteins
pubmed
15363411
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17548353
uniprot
proteins
pubmed
18827011
uniprot
proteins
pubmed
19033398
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21998599
uniprot
proteins
pubmed
30516436
uniprot
proteins
pubmed
36355422
uniprot
proteins
pubmed
9045631
uniprot
proteins
sequence_length
298
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30516436}; Single-pass type IV membrane protein {ECO:0000305}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q08850}. Cell projection, stereocilium {ECO:0000269|PubMed:36355422}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:30516436}. Note=Localizes to neurite tips in neuronal cells. {ECO:0000250|UniProtKB:Q08850}.
uniprot
proteins
transmembrane_region
TRANSMEM 275..295; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins