Npy
entrez
109648
canonical
uniprot
P57774
canonical
ensembl
ENSMUSG00000029819
resolver
ensp
ENSMUSP00000031843
resolver
enst
ENSMUST00000031843
resolver
genesymbol
Npy
resolver
uniprot
Q925V2
resolver
uniprot
Q9ET27
resolver
uniprot_entry
NPY_MOUSE
resolver
uniprot_sec
Q925V2
resolver
uniprot_sec
Q9ET27
resolver
amino_acid_sequence
MLGNKRMGLCGLTLALSLLVCLGILAEGYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMKESTENAPRTRLEDPSMW
uniprot
proteins
function
FUNCTION: [Neuropeptide Y]: Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by NPY also leads to an increase of intracellular Ca(2+) levels. Is involved in the regulation of eating behavior, acting as a stimulator of food intake (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (PubMed:21457230). {ECO:0000250|UniProtKB:P01303, ECO:0000250|UniProtKB:P07808, ECO:0000269|PubMed:21457230}.
uniprot
proteins
mass_dalton
10874
uniprot
proteins
post_translational_modification
PTM: The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro). {ECO:0000250|UniProtKB:P01303}.
uniprot
proteins
protein_family
NPY family
uniprot
proteins
pubmed
11210195
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21457230
uniprot
proteins
pubmed
37545877
uniprot
proteins
sequence_length
97
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:37545877}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle {ECO:0000250|UniProtKB:P07808}.
uniprot
proteins