SPO11
entrez
23626
canonical
uniprot
Q9Y5K1
canonical
ensembl
ENSG00000054796
resolver
ensp
ENSP00000316034
resolver
ensp
ENSP00000360310
resolver
ensp
ENSP00000770968
resolver
genesymbol
SPO11
resolver
hgnc
HGNC:11250
resolver
uniprot
Q5TCI1
resolver
uniprot
Q8N4V0
resolver
uniprot
Q9NQM7
resolver
uniprot
Q9NQM8
resolver
uniprot_entry
SPO11_HUMAN
resolver
uniprot_sec
Q5TCI1
resolver
uniprot_sec
Q8N4V0
resolver
uniprot_sec
Q9NQM7
resolver
uniprot_sec
Q9NQM8
resolver
activity_regulation
ACTIVITY REGULATION: Homodimerization transforms the enzyme from an inactive monomer into a functional dimer capable of catalyzing programmed DNA double-strand breaks (DSBs) to initiate meiosis. {ECO:0000250|UniProtKB:Q9WTK8}.
uniprot
proteins
amino_acid_sequence
MAFAPMGPEASFFDVLDRHRESLLAALRRGGREPPTGGSRLASSSEVLASIENIIQDIITSLARNEAPAFTIDNRSSWENIKFEDSVGLQMVSHCTTRKIKSDSPKSAQKFSLILKILSMIYKLVQSNTYATKRDIYYTDSQLFGNQTVVDNIINDISCMLKVSRRSLHILSTSKGLIAGNLRYIEEDGTKVNCTCGATAVAVPSNIQGIRNLVTDAKFVLIVEKDATFQRLLDDNFCNKLSPCIMITGKGVPDLNTRLLVKKLWDTFHVPVFTLVDADPHGIEIMCIYKYGSMSMSFEAHHLTVPAIRWLGLLPSDLKRLNVPKDSLIPLTKRDQMKLDSILRRPYVTCQPFWRKEMEIMADSKMKAEIQALTFLSSDYLSRVYLPNKLKFGGWI
uniprot
proteins
ec_number
5.6.2.2
uniprot
proteins
function
FUNCTION: DNA endonuclease, which specifically mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. SPO11 covalently attaches itself to the 5' DNA strand during DSB formation and each strand is cleaved by a composite active site assembled at the interface of two SPO11 monomers, with the two cleavages staggered to produce a two-nucleotide 5' overhang. SPO11 cleavage site selection is driven by a mild sequence bias and a preference for bendable and underwound DNA. Together with TOP6BL, promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Required for the phosphorylation of SMC3, HORMAD1 and HORMAD2. {ECO:0000250|UniProtKB:Q9WTK8}.
uniprot
proteins
mass_dalton
44537
uniprot
proteins
protein_family
TOP6A family
uniprot
proteins
pubmed
10534401
uniprot
proteins
pubmed
10622720
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q9WTK8}. Nucleus {ECO:0000250|UniProtKB:Q9WTK8}. Note=Localizes to discrete foci during leptotene and to homologously synapsed chromosomes. {ECO:0000250|UniProtKB:Q9WTK8}.
uniprot
proteins