GPRC5A
entrez
9052
canonical
uniprot
Q8NFJ5
canonical
ensembl
ENSG00000013588
resolver
ensp
ENSP00000014914
resolver
ensp
ENSP00000518866
resolver
ensp
ENSP00000577889
resolver
ensp
ENSP00000577891
resolver
ensp
ENSP00000577892
resolver
ensp
ENSP00000577893
resolver
ensp
ENSP00000577894
resolver
ensp
ENSP00000613627
resolver
ensp
ENSP00000613629
resolver
ensp
ENSP00000613630
resolver
ensp
ENSP00000613631
resolver
enst
ENST00000014914
resolver
enst
ENST00000713574
resolver
enst
ENST00000907830
resolver
enst
ENST00000907832
resolver
enst
ENST00000907833
resolver
enst
ENST00000907834
resolver
enst
ENST00000907835
resolver
enst
ENST00000943568
resolver
enst
ENST00000943570
resolver
enst
ENST00000943571
resolver
enst
ENST00000943572
resolver
genesymbol
GPRC5A
resolver
genesymbol_syn
GPCR5A
resolver
genesymbol_syn
RAI3
resolver
genesymbol_syn
RAIG1
resolver
hgnc
HGNC:9836
resolver
uniprot
B3KV45
resolver
uniprot
O95357
resolver
uniprot_entry
RAI3_HUMAN
resolver
uniprot_sec
B3KV45
resolver
uniprot_sec
O95357
resolver
amino_acid_sequence
MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLTKLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRWDDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS
uniprot
proteins
function
FUNCTION: Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218). {ECO:0000250|UniProtKB:Q8BHL4, ECO:0000269|PubMed:18000218}.
uniprot
proteins
mass_dalton
40251
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in two conserved double-tyrosine motifs, Tyr-317/Tyr-320 and Tyr-347/Tyr-350, by EGFR; leading to inactivation of the tumor suppressive function of GPRC5A in lung cancer cells. Tyr-317 and Tyr-320 are the preferred residues responsible for EGFR-mediated GPRC5A phosphorylation. {ECO:0000269|PubMed:25311788}.
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
pubmed
10783259
uniprot
proteins
pubmed
10945465
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18000218
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25311788
uniprot
proteins
pubmed
8832110
uniprot
proteins
pubmed
9857033
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9857033}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9857033}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in perinuclear vesicles, probably Golgi-associated vesicles. {ECO:0000269|PubMed:18000218}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 98..118; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 130..150; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 248..268; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins