Cirbp
entrez
12696
canonical
uniprot
P60824
canonical
ensembl
ENSMUSG00000045193
resolver
ensp
ENSMUSP00000101004
resolver
ensp
ENSMUSP00000243451
resolver
ensp
ENSMUSP00000332827
resolver
enst
ENSMUST00000105365
resolver
genesymbol
Cirbp
resolver
genesymbol_syn
Cirp
resolver
uniprot
O09069
resolver
uniprot
O09148
resolver
uniprot
Q3V1A6
resolver
uniprot
Q61413
resolver
uniprot_entry
CIRBP_MOUSE
resolver
uniprot_sec
O09069
resolver
uniprot_sec
O09148
resolver
uniprot_sec
Q3V1A6
resolver
uniprot_sec
Q61413
resolver
amino_acid_sequence
MASDEGKLFVGGLSFDTNEQALEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRSRGRGFSRGGGDRGYGGGRFESRSGGYGGSRDYYASRSQGGSYGYRSSGGSYRDSYDSYATHNE
uniprot
proteins
function
FUNCTION: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpressed. Seems to play an essential role in cold-induced suppression of cell proliferation. Acts as a translational repressor. Acts as a translational activator. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. {ECO:0000269|PubMed:17967451, ECO:0000269|PubMed:9151692}.
uniprot
proteins
mass_dalton
18607
uniprot
proteins
mutagenesis
MUTAGEN 91; /note="R->K: Inhibits translational repression."; /evidence="ECO:0000269|PubMed:17967451"; MUTAGEN 94; /note="R->K: Inhibits stress granules localization and translational repression."; /evidence="ECO:0000269|PubMed:17967451"; MUTAGEN 101; /note="R->K: Inhibits translational repression."; /evidence="ECO:0000269|PubMed:17967451"; MUTAGEN 105; /note="R->K: Inhibits stress granules localization and translational repression."; /evidence="ECO:0000269|PubMed:17967451"; MUTAGEN 108; /note="R->K: Inhibits translational repression."; /evidence="ECO:0000269|PubMed:17967451"; MUTAGEN 110; /note="R->K: Inhibits translational repression."; /evidence="ECO:0000269|PubMed:17967451"; MUTAGEN 112; /note="R->K: Inhibits translational repression."; /evidence="ECO:0000269|PubMed:17967451"; MUTAGEN 116; /note="R->K: Inhibits stress granules localization and translational repression."; /evidence="ECO:0000269|PubMed:17967451"; MUTAGEN 121; /note="R->K: Inhibits translational repression."; /evidence="ECO:0000269|PubMed:17967451"; MUTAGEN 127; /note="R->K: Inhibits translational repression."; /evidence="ECO:0000269|PubMed:17967451"; MUTAGEN 131; /note="R->K: Inhibits translational repression."; /evidence="ECO:0000269|PubMed:17967451
uniprot
proteins
post_translational_modification
PTM: Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs. {ECO:0000269|PubMed:17967451}.; PTM: Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17967451
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9151692
uniprot
proteins
sequence_length
172
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:17967451}. Cytoplasm {ECO:0000269|PubMed:17967451}. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation (By similarity). Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins. {ECO:0000250}.
uniprot
proteins