COX8C
entrez
341947
canonical
uniprot
Q7Z4L0
canonical
ensembl
ENSG00000187581
resolver
ensembl
ENSG00000277018
resolver
ensp
ENSP00000340568
resolver
ensp
ENSP00000480706
resolver
enst
ENST00000342144
resolver
enst
ENST00000620478
resolver
genesymbol
COX8C
resolver
hgnc
HGNC:24382
resolver
uniprot
Q495K7
resolver
uniprot_entry
COX8C_HUMAN
resolver
uniprot_sec
Q495K7
resolver
amino_acid_sequence
MPLLRGRCPARRHYRRLALLGLQPAPRFAHSGPPRQRPLSAAEMAVGLVVFFTTFLTPAAYVLGNLKQFRRN
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P10175}.
uniprot
proteins
mass_dalton
8129
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P10175}.
uniprot
proteins
protein_family
Cytochrome c oxidase VIII family
uniprot
proteins
pubmed
12909344
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
72
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P10175}; Single-pass membrane protein {ECO:0000250|UniProtKB:P10175}.
uniprot
proteins
transmembrane_region
TRANSMEM 41..64; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P10175
uniprot
proteins