Hes6
entrez
55927
canonical
uniprot
Q9JHE6
canonical
ensembl
ENSMUSG00000067071
resolver
ensp
ENSMUSP00000084062
resolver
ensp
ENSMUSP00000244799
resolver
ensp
ENSMUSP00000244801
resolver
enst
ENSMUST00000086851
resolver
genesymbol
Hes6
resolver
uniprot
Q3U2D7
resolver
uniprot_entry
HES6_MOUSE
resolver
uniprot_sec
Q3U2D7
resolver
amino_acid_sequence
MAPSQAPSRDRAGQEDEDRWEARGDRKARKPLVEKKRRARINESLQELRLLLAGTEVQAKLENAEVLELTVRRVQGALRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVSAELLNHLLESMPLREGSSFQDLLGDSLAGLPGGSGRSSWPPGGSPESPLSSPPGPGDDLCSDLEEIPEAELNRVPAEGPDLVSTSLGSLTAARRAQSVWRPW
uniprot
proteins
function
FUNCTION: Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation. {ECO:0000269|PubMed:10851137}.
uniprot
proteins
mass_dalton
24454
uniprot
proteins
pubmed
10851137
uniprot
proteins
pubmed
10906477
uniprot
proteins
pubmed
11044617
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins