Kcnab1
entrez
16497
canonical
uniprot
P63143
canonical
ensembl
ENSMUSG00000027827
resolver
ensp
ENSMUSP00000047480
resolver
ensp
ENSMUSP00000158882
resolver
ensp
ENSMUSP00000159000
resolver
enst
ENSMUST00000049230
resolver
enst
ENSMUST00000238901
resolver
enst
ENSMUST00000239069
resolver
genesymbol
Kcnab1
resolver
genesymbol_syn
Kvb1
resolver
uniprot
A0A5F8MPA4
resolver
uniprot
A0A5F8MPK0
resolver
uniprot
P97380
resolver
uniprot
Q3U6C5
resolver
uniprot
Q61763
resolver
uniprot
Q63277
resolver
uniprot
Q8CD65
resolver
uniprot
Q91WM5
resolver
uniprot_entry
A0A5F8MPA4_MOUSE
resolver
uniprot_entry
A0A5F8MPK0_MOUSE
resolver
uniprot_entry
KCAB1_MOUSE
resolver
uniprot_entry
Q3U6C5_MOUSE
resolver
uniprot_entry
Q8CD65_MOUSE
resolver
uniprot_sec
P97380
resolver
uniprot_sec
Q61763
resolver
uniprot_sec
Q63277
resolver
uniprot_sec
Q91WM5
resolver
amino_acid_sequence
MQVSIACTEHNLKSRNGEDRLLSKQSSNAPNVVNAARAKFRTVAIIARSLGTFTPQHHISLKESTAKQTGMKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILRNKPYSKKDYRS
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
function
FUNCTION: Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:10454353). The beta-1/KCNAB1 cytoplasmic subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members. Promotes the inactivation of KCNA1, KCNA2, KCNA4, KCNA5 and KCNA6 alpha subunit-containing channels (By similarity). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a variety of endogenous aldehydes and ketones (By similarity). The binding of NADPH is required for efficient down-regulation of potassium channel activity (By similarity). Oxidation of the bound NADPH restrains N-terminal domain from blocking the channel, thereby decreasing N-type inactivation of potassium channel activity (By similarity). {ECO:0000250|UniProtKB:P63144, ECO:0000250|UniProtKB:Q14722, ECO:0000269|PubMed:10454353}.
uniprot
proteins
mass_dalton
44723
uniprot
proteins
protein_family
Shaker potassium channel beta subunit family
uniprot
proteins
pubmed
10454353
uniprot
proteins
pubmed
14511342
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15530391
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8824288
uniprot
proteins
pubmed
9468385
uniprot
proteins
sequence_length
401
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14722}. Membrane {ECO:0000250|UniProtKB:P63144}; Peripheral membrane protein {ECO:0000250|UniProtKB:P63144}; Cytoplasmic side {ECO:0000250|UniProtKB:P63144}. Cell membrane {ECO:0000250|UniProtKB:Q14722}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14722}; Cytoplasmic side {ECO:0000250|UniProtKB:Q14722}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. {ECO:0000250|UniProtKB:Q14722}.
uniprot
proteins