CUL9
entrez
23113
canonical
uniprot
Q8IWT3
canonical
ensembl
ENSG00000112659
resolver
ensp
ENSP00000252050
resolver
ensp
ENSP00000555155
resolver
ensp
ENSP00000555156
resolver
ensp
ENSP00000555157
resolver
ensp
ENSP00000782594
resolver
genesymbol
CUL9
resolver
genesymbol_syn
H7AP1
resolver
genesymbol_syn
KIAA0708
resolver
genesymbol_syn
PARC
resolver
hgnc
HGNC:15982
resolver
uniprot
O75188
resolver
uniprot
Q5TCY3
resolver
uniprot
Q68CP2
resolver
uniprot
Q68D92
resolver
uniprot
Q8N3W9
resolver
uniprot
Q9BU56
resolver
uniprot_entry
CUL9_HUMAN
resolver
uniprot_sec
O75188
resolver
uniprot_sec
Q5TCY3
resolver
uniprot_sec
Q68CP2
resolver
uniprot_sec
Q68D92
resolver
uniprot_sec
Q8N3W9
resolver
uniprot_sec
Q9BU56
resolver
amino_acid_sequence
MVGERHAGDLMVPLGPRLQAYPEELIRQRPGHDGHPEYLIRWSVLKCGEVGKVGVEEGKAEHILMWLSAPEVYANCPGLLGERALSKGLQHEPAGVSGSFPRDPGGLDEVAMGEMEADVQALVRRAARQLAESGTPSLTAAVLHTIHVLSAYASIGPLTGVFRETGALDLLMHMLCNPEPQIRRSAGKMLQALAAHDAGSRAHVLLSLSQQDGIEQHMDFDSRYTLLELFAETTSSEEHCMAFEGIHLPQIPGKLLFSLVKRYLCVTSLLDQLNSSPELGAGDQSSPCATREKSRGQRELEFSMAVGNLISELVRSMGWARNLSEQGMSPPRPTRSIFQPYISGPSLLLPTIVTTPRRQGWVFRQRSEFSSRSGYGEYVQQTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGIPPVQVFWQSTGRTYWVHWHMLEILGPEEATEDKASAAVEKGAGATVLGTAFPSWDWNPMDGLYPLPYLQPEPQKNERVGYLTQAEWWELLFFIKKLDLCEQQPIFQNLWKNLDETLGEKALGEISVSVEMAESLLQVLSSRFEGSTLNDLLNSQIYTKYGLLSNEPSSSSTSRNHSCTPDPEEESKSEASFSEEETESLKAKAEAPKTEAEPTKTRTETPMAQSDSQLFNQLLVTEGMTLPTEMKEAASEMARALRGPGPRSSLDQHVAAVVATVQISSLDTNLQLSGLSALSQAVEEVTERDHPLVRPDRSLREKLVKMLVELLTNQVGEKMVVVQALRLLYLLMTKHEWRPLFAREGGIYAVLVCMQEYKTSVLVQQAGLAALKMLAVASSSEIPTFVTGRDSIHSLFDAQMTREIFASIDSATRPGSESLLLTVPAAVILMLNTEGCSSAARNGLLLLNLLLCNHHTLGDQIITQELRDTLFRHSGIAPRTEPMPTTRTILMMLLNRYSEPPGSPERAALETPIIQGQDGSPELLIRSLVGGPSAELLLDLERVLCREGSPGGAVRPLLKRLQQETQPFLLLLRTLDAPGPNKTLLLSVLRVITRLLDFPEAMVLPWHEVLEPCLNCLSGPSSDSEIVQELTCFLHRLASMHKDYAVVLCCLGAKEILSKVLDKHSAQLLLGCELRDLVTECEKYAQLYSNLTSSILAGCIQMVLGQIEDHRRTHQPINIPFFDVFLRHLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGSTGSHYITLHMHRGVLVRQLTLLVASEDSSYMPARVVVFGGDSTSCIGTELNTVNVMPSASRVILLENLNRFWPIIQIRIKRCQQGGIDTRVRGVEVLGPKPTFWPLFREQLCRRTCLFYTIRAQAWSRDIAEDHRRLLQLCPRLNRVLRHEQNFADRFLPDDEAAQALGKTCWEALVSPLVQNITSPDAEGVSALGWLLDQYLEQRETSRNPLSRAASFASRVRRLCHLLVHVEPPPGPSPEPSTRPFSKNSKGRDRSPAPSPVLPSSSLRNITQCWLSVVQEQVSRFLAAAWRAPDFVPRYCKLYEHLQRAGSELFGPRAAFMLALRSGFSGALLQQSFLTAAHMSEQFARYIDQQIQGGLIGGAPGVEMLGQLQRHLEPIMVLSGLELATTFEHFYQHYMADRLLSFGSSWLEGAVLEQIGLCFPNRLPQLMLQSLSTSEELQRQFHLFQLQRLDKLFLEQEDEEEKRLEEEEEEEEEEEAEKELFIEDPSPAISILVLSPRCWPVSPLCYLYHPRKCLPTEFCDALDRFSSFYSQSQNHPVLDMGPHRRLQWTWLGRAELQFGKQILHVSTVQMWLLLKFNQTEEVSVETLLKDSDLSPELLLQALVPLTSGNGPLTLHEGQDFPHGGVLRLHEPGPQRSGEALWLIPPQAYLNVEKDEGRTLEQKRNLLSCLLVRILKAHGEKGLHIDQLVCLVLEAWQKGPNPPGTLGHTVAGGVACTSTDVLSCILHLLGQGYVKRRDDRPQILMYAAPEPMGPCRGQADVPFCGSQSETSKPSPEAVATLASLQLPAGRTMSPQEVEGLMKQTVRQVQETLNLEPDVAQHLLAHSHWGAEQLLQSYSEDPEPLLLAAGLCVHQAQAVPVRPDHCPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFIRAIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGTTCSKCGWASCFNCSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQAPIEKNEGCLHMTCAKCNHGFCWRCLKSWKPNHKDYYNCSAMVSKAARQEKRFQDYNERCTFHHQAREFAVNLRNRVSAIHEVPPPRSFTFLNDACQGLEQARKVLAYACVYSFYSQDAEYMDVVEQQTENLELHTNALQILLEETLLRCRDLASSLRLLRADCLSTGMELLRRIQERLLAILQHSAQDFRVGLQSPSVEAWEAKGPNMPGSQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLDQETFFFGDEEEDEDEAYD
uniprot
proteins
function
FUNCTION: Core component of a Cul9-RING ubiquitin-protein ligase complex composed of CUL9 and RBX1 (PubMed:38605244). The CUL9-RBX1 complex mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits the ubiquitination of BIRC5 (PubMed:24793696). The CUL9-RBX1 complex also mediates mono-ubiquitination of p53/TP53 (PubMed:38605244). Acts as a cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and its subsequent function (PubMed:12526791, PubMed:17332328). Ubiquitinates apurinic/apyrimidinic endodeoxyribonuclease APEX2 (PubMed:38605244). Ubiquitination by the CUL9-RBX1 complex is predominantly mediated by E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2D2 (PubMed:38605244). {ECO:0000269|PubMed:12526791, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:24793696, ECO:0000269|PubMed:38605244}.
uniprot
proteins
mass_dalton
281229
uniprot
proteins
mutagenesis
MUTAGEN 125; /note="R->A: Dimeric; disrupts the hexamerization of the CUL9-RBX1 complex; when associated with A-152. Monomeric; abolishes ubiquitination of TP53; when associated with 1650-F--D-1690 del."; /evidence="ECO:0000269|PubMed:38605244"; MUTAGEN 152; /note="Y->A: Dimeric; disrupts the hexamerization of the CUL9-RBX1 complex; when associated with A-125. Monomeric; abolishes ubiquitination of TP53; when associated with 1650-F--D-1690 del."; /evidence="ECO:0000269|PubMed:38605244"; MUTAGEN 1650..1690; /note="Missing: Dimeric; disrupts the hexamerization of the CUL9-RBX1 complex and abolishes ubiquitination of TP53 and APEX2. Monomeric; abolishes ubiquitination of TP53 and APEX2; when associated with A-125 or A-152."; /evidence="ECO:0000269|PubMed:38605244"; MUTAGEN 1881; /note="K->R: Abolishes neddylation. Abolishes ubiquitination of TP53 and APEX2 by the CUL9-RBX1 complex."; /evidence="ECO:0000269|PubMed:38605244"; MUTAGEN 2249; /note="C->A: Abolishes ubiquitination of TP53 and APEX2 by the CUL9-RBX1 complex."; /evidence="ECO:0000269|PubMed:38605244
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU01426}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated by the CUL9-RBX1 complex at Lys-87. {ECO:0000269|PubMed:38605244}.; PTM: Neddylated (PubMed:17332328, PubMed:38605244). Neddylation is mediated by E1 enzyme UBA3-NAE1 complex and E2 enzyme UBE2F (PubMed:38605244). Structural rearrangment of the C-terminal TRIAD/RBR supradomain may play a role in neddylation and deneddylation (PubMed:38605244). {ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:38605244}.
uniprot
proteins
protein_family
Cullin family
uniprot
proteins
pubmed
10521492
uniprot
proteins
pubmed
12526791
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15964813
uniprot
proteins
pubmed
17332328
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24793696
uniprot
proteins
pubmed
38605244
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
2517
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12526791}.
uniprot
proteins