Commd1
entrez
17846
canonical
uniprot
Q8K4M5
canonical
ensembl
ENSMUSG00000051355
resolver
ensp
ENSMUSP00000053606
resolver
ensp
ENSMUSP00000124719
resolver
ensp
ENSMUSP00000255404
resolver
enst
ENSMUST00000159081
resolver
genesymbol
Commd1
resolver
genesymbol_syn
Murr1
resolver
uniprot
A2RSF1
resolver
uniprot
Q3V012
resolver
uniprot
Q80WG2
resolver
uniprot
Q80Z41
resolver
uniprot
Q8BNL9
resolver
uniprot
Q8K2S9
resolver
uniprot_entry
A2RSF1_MOUSE
resolver
uniprot_entry
COMD1_MOUSE
resolver
uniprot_sec
Q3V012
resolver
uniprot_sec
Q80WG2
resolver
uniprot_sec
Q80Z41
resolver
uniprot_sec
Q8BNL9
resolver
uniprot_sec
Q8K2S9
resolver
amino_acid_sequence
MAGDLEGGKSLSGLLSGLAQNAFHGHSGVTEELLHSQLYPEVPPEEFRPFLAKMRGLLKSIASADMDFNQLEAFLTAQTKKQGGITSEQAAVISKFWKSHKIKIRESLMKQSRWDNGLRGLSWRVDGKSQSRHSTQIHSPVAIIELEFGKNGQESEFLCLEFDEVKVKQILKKLSEVEESINRLMQAA
uniprot
proteins
function
FUNCTION: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (By similarity). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (By similarity). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (By similarity). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (By similarity). Promotes CFTR cell surface expression through regulation of its ubiquitination (By similarity). Down-regulates SOD1 activity by interfering with its homodimerization (By similarity). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (By similarity). Can bind one copper ion per monomer (By similarity). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (By similarity). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (By similarity). Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q8N668}.
uniprot
proteins
mass_dalton
20996
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; undergoes both 'Lys-63'- and 'Lys-48'-linked polyubiquitination. Ubiquitinated by XIAP, leading to its proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:Q8N668}.
uniprot
proteins
protein_family
COMM domain-containing protein 1 family
uniprot
proteins
pubmed
14673161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
188
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N668}. Cytoplasm {ECO:0000250|UniProtKB:Q8N668}. Endosome membrane {ECO:0000250|UniProtKB:Q8N668}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q8N668}. Early endosome {ECO:0000250|UniProtKB:Q8N668}. Recycling endosome {ECO:0000250|UniProtKB:Q8N668}. Note=Shuttles between nucleus and cytosol. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins (By similarity). {ECO:0000250|UniProtKB:Q8N668}.
uniprot
proteins