SAMD1
entrez
90378
canonical
uniprot
Q6SPF0
canonical
ensembl
ENSG00000288488
resolver
ensp
ENSP00000500116
resolver
enst
ENST00000673075
resolver
genesymbol
SAMD1
resolver
hgnc
HGNC:17958
resolver
uniprot
Q6P0R3
resolver
uniprot
Q6PIS7
resolver
uniprot
Q96IM4
resolver
uniprot_entry
SAMD1_HUMAN
resolver
uniprot_sec
Q6P0R3
resolver
uniprot_sec
Q6PIS7
resolver
uniprot_sec
Q96IM4
resolver
amino_acid_sequence
MAGPPALPPPETAAAATTAAAASSSAASPHYQEWILDTIDSLRSRKARPDLERICRMVRRRHGPEPERTRAELEKLIQQRAVLRVSYKGSISYRNAARVQPPRRGATPPAPPRAPRGAPAAAAAAAPPPTPAPPPPPAPVAAAAPARAPRAAAAAATAPPSPGPAQPGPRAQRAAPLAAPPPAPAAPPAVAPPAGPRRAPPPAVAAREPPLPPPPQPPAPPQQQQPPPPQPQPPPEGGAVRAGGAARPVSLREVVRYLGGSGGAGGRLTRGRVQGLLEEEAAARGRLERTRLGALALPRGDRPGRAPPAASARPSRSKRGGEERVLEKEEEEDDDEDEDEEDDVSEGSEVPESDRPAGAQHHQLNGERGPQSAKERVKEWTPCGPHQGQDEGRGPAPGSGTRQVFSMAAMNKEGGTASVATGPDSPSPVPLPPGKPALPGADGTPFGCPPGRKEKPSDPVEWTVMDVVEYFTEAGFPEQATAFQEQEIDGKSLLLMQRTDVLTGLSIRLGPALKIYEHHIKVLQQGHFEDDDPDGFLG
uniprot
proteins
function
FUNCTION: Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor (PubMed:33980486). Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs (PubMed:33980486). Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell (PubMed:16159594, PubMed:34006929). {ECO:0000269|PubMed:16159594, ECO:0000269|PubMed:33980486, ECO:0000269|PubMed:34006929}.
uniprot
proteins
mass_dalton
56052
uniprot
proteins
mutagenesis
MUTAGEN 43; /note="R->A: Slightly decreases binding to unmethylated CpG islands."; /evidence="ECO:0000269|PubMed:33980486"; MUTAGEN 45..46; /note="RK->AA: Strongly decreases binding to unmethylated CpG islands. Abolishes interaction with KDM1A."; /evidence="ECO:0000269|PubMed:33980486"; MUTAGEN 48; /note="R->A: Decreases binding to unmethylated CpG islands."; /evidence="ECO:0000269|PubMed:33980486"; MUTAGEN 87..88; /note="YK->AA: Decreases binding to unmethylated CpG islands."; /evidence="ECO:0000269|PubMed:33980486"; MUTAGEN 94; /note="R->A: Decreases binding to unmethylated CpG islands."; /evidence="ECO:0000269|PubMed:33980486"; MUTAGEN 498..514; /note="RTDVLTGLSIRLGPALK->ATDVLTGLSIRLGPALA: Abolishes interaction with L3MBTL3."; /evidence="ECO:0000269|PubMed:33980486
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16159594
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
33980486
uniprot
proteins
pubmed
34006929
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34006929}. Chromosome {ECO:0000269|PubMed:34006929}. Secreted {ECO:0000269|PubMed:16159594, ECO:0000269|PubMed:34006929}. Note=In atherosclerotic lesions, it is found in the extracellular compartment and in foam cells cytoplasm. {ECO:0000269|PubMed:16159594, ECO:0000269|PubMed:34006929}.
uniprot
proteins