Ghr
entrez
14600
canonical
uniprot
P16882
canonical
ensembl
ENSMUSG00000055737
resolver
ensp
ENSMUSP00000069457
resolver
ensp
ENSMUSP00000106326
resolver
ensp
ENSMUSP00000124064
resolver
enst
ENSMUST00000069451
resolver
enst
ENSMUST00000161561
resolver
genesymbol
Ghr
resolver
uniprot
F6U2K9
resolver
uniprot
P16590
resolver
uniprot
Q3UNY8
resolver
uniprot
Q3UP14
resolver
uniprot
Q61653
resolver
uniprot
Q6DI66
resolver
uniprot
Q80W86
resolver
uniprot
Q8R1M5
resolver
uniprot
Q920Z3
resolver
uniprot
Q9R264
resolver
uniprot_entry
F6U2K9_MOUSE
resolver
uniprot_entry
GHR_MOUSE
resolver
uniprot_entry
Q3UNY8_MOUSE
resolver
uniprot_entry
Q3UP14_MOUSE
resolver
uniprot_sec
P16590
resolver
uniprot_sec
Q61653
resolver
uniprot_sec
Q6DI66
resolver
uniprot_sec
Q80W86
resolver
uniprot_sec
Q8R1M5
resolver
uniprot_sec
Q920Z3
resolver
uniprot_sec
Q9R264
resolver
amino_acid_sequence
MDLCQVFLTLALAVTSSTFSGSEATPATLGKASPVLQRINPSLGTSSSGKPRFTKCRSPELETFSCYWTEGDNPDLKTPGSIQLYYAKRESQRQAARIAHEWTQEWKECPDYVSAGKNSCYFNSSYTSIWIPYCIKLTTNGDLLDQKCFTVDEIVQPDPPIGLNWTLLNISLTGIRGDIQVSWQPPPNADVLKGWIILEYEIQYKEVNESKWKVMGPIWLTYCPVYSLRMDKEHEVRVRSRQRSFEKYSEFSEVLRVIFPQTNILEACEEDIQFPWFLIIIFGIFGVAVMLFVVIFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILGIHDNYKPDFYNDDSWVEFIELDIDEADVDEKTEGSDTDRLLSNDHEKSAGILGAKDDDSGRTSCYDPDILDTDFHTSDMCDGTLKFRQSQKLNMEADLLCLDQKNLKNLPYDASLGSLHPSITQTVEENKPQPLLSSETEATHQLASTPMSNPTSLANIDFYAQVSDITPAGGDVLSPGQKIKAGIAQGNTQREVATPCQENYSMNSAYFCESDAKKCIAVARRMEATSCIKPSFNQEDIYITTESLTTTAQMSETADIAPDAEMSVPDYTTVHTVQSPRGLILNATALPLPDKKNFPSSCGYVSTDQLNKIMQ
uniprot
proteins
function
FUNCTION: Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. {ECO:0000250|UniProtKB:P10912}.; FUNCTION: [Growth hormone-binding protein]: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. {ECO:0000250|UniProtKB:P10912}.
uniprot
proteins
mass_dalton
72783
uniprot
proteins
post_translational_modification
PTM: The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE (By similarity). Shedding is inhibited by growth hormone (GH) binding to the receptor probably due to a conformational change in GHR rendering the receptor inaccessible to ADAM17 (By similarity). {ECO:0000250|UniProtKB:P10912, ECO:0000250|UniProtKB:P19941}.; PTM: On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2. {ECO:0000269|PubMed:21980433}.; PTM: Ubiquitinated by the ECS(SOCS2) complex following ligand-binding and phosphorylation by JAK2, leading to its degradation by the proteasome (PubMed:21980433). Regulation by the ECS(SOCS2) complex acts as a negative feedback loop of growth hormone receptor signaling (PubMed:21980433). Ubiquitination is not sufficient for GHR internalization (By similarity). {ECO:0000250|UniProtKB:P19941, ECO:0000269|PubMed:21980433}.
uniprot
proteins
protein_family
Type 1 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
10425445
uniprot
proteins
pubmed
12379490
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21980433
uniprot
proteins
pubmed
2739661
uniprot
proteins
pubmed
3398846
uniprot
proteins
pubmed
7894338
uniprot
proteins
pubmed
7988474
uniprot
proteins
sequence_length
650
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P10912}; Single-pass type I membrane protein {ECO:0000255}. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway. {ECO:0000250|UniProtKB:P19941}.; SUBCELLULAR LOCATION: [Growth hormone-binding protein]: Secreted {ECO:0000250|UniProtKB:P10912}. Note=Complexed to a substantial fraction of circulating GH. {ECO:0000250|UniProtKB:P10912}.
uniprot
proteins
transmembrane_region
TRANSMEM 274..297; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins