Snx3
entrez
54198
canonical
uniprot
O70492
canonical
ensembl
ENSMUSG00000019804
resolver
ensp
ENSMUSP00000019939
resolver
genesymbol
Snx3
resolver
uniprot
Q78ZM0
resolver
uniprot_entry
SNX3_MOUSE
resolver
uniprot_sec
Q78ZM0
resolver
amino_acid_sequence
MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
uniprot
proteins
function
FUNCTION: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (PubMed:19576982). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC). May act in part as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (By similarity). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (PubMed:18632802). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (By similarity). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor Tfrc presuambly by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (PubMed:23416069). Involved in regulation of neurite outgrowth in primary neurons (PubMed:19576982). Required for trafficking of WLS to the early endosome for recycling which promotes both canonical and non-canonical WNT signaling and is essential for neural tube closure (PubMed:33214242). {ECO:0000250|UniProtKB:O60493, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:23416069, ECO:0000269|PubMed:33214242}.
uniprot
proteins
mass_dalton
18762
uniprot
proteins
mutagenesis
MUTAGEN 152; /note="K->A: Abolishes phosphoinositide-binding of C-terminus; when associated with A-158, A-160 and A-161."; /evidence="ECO:0000269|PubMed:19576982"; MUTAGEN 158; /note="K->A: Abolishes phosphoinositide-binding of C-terminus; when associated with A-152, A-160 and A-161."; /evidence="ECO:0000269|PubMed:19576982"; MUTAGEN 160; /note="R->A: Abolishes phosphoinositide-binding of C-terminus; when associated with A-152, A-160 and A-161."; /evidence="ECO:0000269|PubMed:19576982"; MUTAGEN 161; /note="H->A: Abolishes phosphoinositide-binding of C-terminus; when associated with A-152, A-158 and A-160."; /evidence="ECO:0000269|PubMed:19576982
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP10. {ECO:0000269|PubMed:18632802}.
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
12079282
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18632802
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19576982
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23416069
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
33214242
uniprot
proteins
sequence_length
162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:23416069, ECO:0000269|PubMed:33214242}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:O60493}. Note=Colocalizes to clathrin-coated endosomal vesicles morphologically distinct from retromer-decorated non-branched endosomal tubule structures. Colocalizes with EEA1 on nascent phagosomes in dendritic cells but competes with EEA1 for binding to phagosomal membrane (By similarity). {ECO:0000250|UniProtKB:O60493, ECO:0000269|PubMed:23416069}.
uniprot
proteins