Nrg4
entrez
83961
canonical
uniprot
Q9WTX4
canonical
ensembl
ENSMUSG00000032311
resolver
ensp
ENSMUSP00000115247
resolver
ensp
ENSMUSP00000130929
resolver
ensp
ENSMUSP00000269767
resolver
ensp
ENSMUSP00000269769
resolver
ensp
ENSMUSP00000335349
resolver
enst
ENSMUST00000130158
resolver
enst
ENSMUST00000164721
resolver
genesymbol
Nrg4
resolver
uniprot_entry
NRG4_MOUSE
resolver
amino_acid_sequence
MPTDHEQPCGPRHRSFCLNGGICYVIPTIPSPFCRCIENYTGARCEEVFLPSSSIPSESNLSAAFVVLAVLLTLTIAALCFLCRKGHLQRASSVQCEISLVETNNTRTRHSHREH
uniprot
proteins
function
FUNCTION: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. {ECO:0000269|PubMed:10348342}.
uniprot
proteins
mass_dalton
12744
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. {ECO:0000250}.; PTM: Extensive glycosylation precedes the proteolytic cleavage. {ECO:0000250}.
uniprot
proteins
protein_family
Neuregulin family
uniprot
proteins
pubmed
10348342
uniprot
proteins
sequence_length
115
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Pro-neuregulin-4, membrane-bound isoform]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.; SUBCELLULAR LOCATION: [Neuregulin-4]: Secreted {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 63..83; /note="Helical; Note=Internal signal sequence"; /evidence="ECO:0000255
uniprot
proteins