PFKM
entrez
5213
canonical
uniprot
P08237
canonical
ensembl
ENSG00000152556
resolver
ensp
ENSP00000309438
resolver
ensp
ENSP00000345771
resolver
ensp
ENSP00000352842
resolver
ensp
ENSP00000446829
resolver
ensp
ENSP00000446945
resolver
ensp
ENSP00000447997
resolver
ensp
ENSP00000449426
resolver
ensp
ENSP00000450369
resolver
ensp
ENSP00000496597
resolver
ensp
ENSP00000543577
resolver
ensp
ENSP00000543587
resolver
ensp
ENSP00000543588
resolver
ensp
ENSP00000543589
resolver
ensp
ENSP00000543594
resolver
ensp
ENSP00000612286
resolver
enst
ENST00000550257
resolver
enst
ENST00000642730
resolver
genesymbol
PFKM
resolver
genesymbol_syn
PFKX
resolver
hgnc
HGNC:8877
resolver
uniprot
A0A024R0Y5
resolver
uniprot
A0A0S2Z4I1
resolver
uniprot
A0A2R8Y891
resolver
uniprot
F8VTQ3
resolver
uniprot
J3KNX3
resolver
uniprot
Q16814
resolver
uniprot
Q16815
resolver
uniprot
Q6ZTT1
resolver
uniprot_entry
A0A024R0Y5_HUMAN
resolver
uniprot_entry
A0A0S2Z4I1_HUMAN
resolver
uniprot_entry
A0A2R8Y891_HUMAN
resolver
uniprot_entry
F8VTQ3_HUMAN
resolver
uniprot_entry
PFKAM_HUMAN
resolver
uniprot_sec
J3KNX3
resolver
uniprot_sec
Q16814
resolver
uniprot_sec
Q16815
resolver
uniprot_sec
Q6ZTT1
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
uniprot
proteins
amino_acid_sequence
MTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRPPVSKSGSHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKRSGEAAV
uniprot
proteins
disease_involvement
DISEASE: Glycogen storage disease 7 (GSD7) [MIM:232800]: A metabolic disorder characterized by exercise intolerance with associated nausea and vomiting, muscle cramping, exertional myopathy and compensated hemolysis. Short bursts of intense activity are particularly difficult. Severe muscle cramps and myoglobinuria develop after vigorous exercise. {ECO:0000269|PubMed:22133655, ECO:0000269|PubMed:24427140, ECO:0000269|PubMed:7513946, ECO:0000269|PubMed:7825568, ECO:0000269|PubMed:8037209, ECO:0000269|PubMed:8889589}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.1.11
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
uniprot
proteins
mass_dalton
85183
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. {ECO:0000255|HAMAP-Rule:MF_03184}.
uniprot
proteins
post_translational_modification
PTM: GlcNAcylation decreases enzyme activity. {ECO:0000250}.
uniprot
proteins
protein_family
ATP-dependent PFK group I subfamily
uniprot
proteins
protein_family
Eukaryotic two domain clade 'E' sub-subfamily
uniprot
proteins
protein_family
Phosphofructokinase type A (PFKA) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
1833270
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2140567
uniprot
proteins
pubmed
22133655
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24427140
uniprot
proteins
pubmed
2526044
uniprot
proteins
pubmed
2526045
uniprot
proteins
pubmed
2822475
uniprot
proteins
pubmed
29775581
uniprot
proteins
pubmed
7513946
uniprot
proteins
pubmed
7550225
uniprot
proteins
pubmed
7825568
uniprot
proteins
pubmed
8037209
uniprot
proteins
pubmed
8889589
uniprot
proteins
sequence_length
780
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}.
uniprot
proteins