Cnot3
entrez
232791
canonical
uniprot
Q8K0V4
canonical
ensembl
ENSMUSG00000035632
resolver
ensp
ENSMUSP00000039098
resolver
ensp
ENSMUSP00000188126
resolver
ensp
ENSMUSP00000188130
resolver
ensp
ENSMUSP00000188133
resolver
ensp
ENSMUSP00000188134
resolver
ensp
ENSMUSP00000188135
resolver
ensp
ENSMUSP00000188138
resolver
ensp
ENSMUSP00000328401
resolver
ensp
ENSMUSP00000328407
resolver
enst
ENSMUST00000038913
resolver
genesymbol
Cnot3
resolver
genesymbol_syn
Not3
resolver
uniprot
B2RUA7
resolver
uniprot_entry
CNOT3_MOUSE
resolver
uniprot_sec
B2RUA7
resolver
amino_acid_sequence
MADKRKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAANANQKEKYEADLKKEIKKLQRLRDQIKTWVASNEIKDKRQLIENRKLIETQMERFKVVERETKTKAYSKEGLGLAQKVDPAQKEKEEVGQWLTNTIDTLNMQVDQFESEVESLSVQTRKKKGDKDKQDRIEGLKRHIEKHRYHVRMLETILRMLDNDSILVDAIRKIKDDVEYYVDSSQDPDFEENEFLYDDLDLEDIPQALVATSPPSHSHMEDEIFNQSSSTPTSTTSSSPIPPSPANCTTENSEDDKKRGRSTDSEVSQSPAKNGSKPVHSNQHPQSPAVPPTYPSGPPPTTSALSSTPGNNGASTPAAPTSALGPKASPAPSHNSGTPAPYAQAVAPPNASGPSNAQPRPPSAQPSGGSGGGSGGSSSNSNSGTGGGAGKQNGATSYSSVVADSPAEVTLSSSGGSSASSQALGPTSGPHNPAPSTSKESSTAAPSGAGNVASGSGNNSGGPSLLVPLPVNPPSSPTPSFSEAKAAGTLLNGPPQFSTTPEIKAPEPLSSLKSMAERAAISSGIEDPVPTLHLTDRDIILSSTSAPPTSSQPPLQLSEVNIPLSLGVCPLGPVSLTKEQLYQQAMEEAAWHHMPHPSDSERIRQYLPRNPCPTPPYHHQMPPPHSDTVEFYQRLSTETLFFIFYYLEGTKAQYLAAKALKKQSWRFHTKYMMWFQRHEEPKTITDEFEQGTYIYFDYEKWGQRKKEGFTFEYRYLEDRDLQ
uniprot
proteins
function
FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:34210974). Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages. {ECO:0000269|PubMed:21897366, ECO:0000269|PubMed:22367759, ECO:0000269|PubMed:34210974}.
uniprot
proteins
mass_dalton
81946
uniprot
proteins
protein_family
CNOT2/3/5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20133598
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21897366
uniprot
proteins
pubmed
22367759
uniprot
proteins
pubmed
34210974
uniprot
proteins
sequence_length
751
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:20133598}. Cytoplasm, P-body {ECO:0000269|PubMed:20133598}. Note=NANOS2 promotes its localization to P-body.
uniprot
proteins