Rad51c
entrez
114714
canonical
uniprot
Q924H5
canonical
ensembl
ENSMUSG00000007646
resolver
ensp
ENSMUSP00000007790
resolver
ensp
ENSMUSP00000064079
resolver
ensp
ENSMUSP00000347436
resolver
genesymbol
Rad51c
resolver
genesymbol_syn
Rad51l2
resolver
uniprot
B2KGK7
resolver
uniprot
Q5SX32
resolver
uniprot
Q8C653
resolver
uniprot_entry
RA51C_MOUSE
resolver
uniprot_sec
B2KGK7
resolver
uniprot_sec
Q5SX32
resolver
uniprot_sec
Q8C653
resolver
amino_acid_sequence
MQRELVGYPLSPAVRGKLVAAGFQTAEDVLEVKPSELSKEVGISKEEALETLQILRRECLTNKPRCAGTSVANEKCTALELLEQEHTQGFIITFCSALDNILGGGIPLMKTTEVCGVPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVSLATACIQHLHLIAGTHTEEEHQKALKDFTLENILSHIYYFRCHDYTELLAQVYLLPDFLSDHPKVQLVIIDGIAFPFRHDLEDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKIDKNQALLVPALGESWGHAATIRLIFHWEQKQRFATLYKSPSQKESTIPFQITPQGFRDAVVTAASSQTESSLNFRKRSREPEEEC
uniprot
proteins
function
FUNCTION: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD51 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis. {ECO:0000269|PubMed:20471405}.
uniprot
proteins
mass_dalton
40675
uniprot
proteins
protein_family
RAD51 subfamily
uniprot
proteins
protein_family
RecA family
uniprot
proteins
pubmed
11410366
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20471405
uniprot
proteins
pubmed
24005329
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43502}. Cytoplasm {ECO:0000250|UniProtKB:O43502}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O43502}. Mitochondrion {ECO:0000250|UniProtKB:O43502}. Note=DNA damage induces an increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA. {ECO:0000250|UniProtKB:O43502}.
uniprot
proteins