Rhbdf1
entrez
13650
canonical
uniprot
Q6PIX5
canonical
ensembl
ENSMUSG00000020282
resolver
ensp
ENSMUSP00000020524
resolver
ensp
ENSMUSP00000178460
resolver
ensp
ENSMUSP00000178474
resolver
ensp
ENSMUSP00000178498
resolver
genesymbol
Rhbdf1
resolver
genesymbol_syn
Dist1
resolver
genesymbol_syn
Irhom1
resolver
genesymbol_syn
Kiaa4242
resolver
uniprot
A2AVE2
resolver
uniprot
Q04843
resolver
uniprot
Q5DTF4
resolver
uniprot
Q6PJ49
resolver
uniprot
Q8VIK0
resolver
uniprot_entry
RHDF1_MOUSE
resolver
uniprot_sec
A2AVE2
resolver
uniprot_sec
Q04843
resolver
uniprot_sec
Q5DTF4
resolver
uniprot_sec
Q6PJ49
resolver
uniprot_sec
Q8VIK0
resolver
amino_acid_sequence
MSEARRDSTSSLQRKKPPWLKLDIPAAVPPAAEEPSFLQPLRRQAFLRSVSMPAETARVPSPHHEPRRLVLQRQTSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRMADDTADGLSAPHTPVTPGAASLCSFSSSRSGFNRLPRRRKRESVAKMSFRAAAALVKGRSIRDGTLRRGQRRSFTPASFLEEDMVDFPDELDTSFFAREGVLHEEMSTYPDEVFESPSEAALKDWEKAPDQADLTGGALDRSELERSHLMLPLERGWRKQKEGGPLAPQPKVRLRQEVVSAAGPRRGQRIAVPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSYVKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGIAPVGFSQHETVDSVLRKRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHSFILAAREREKHSACCVRNDRSGCVQTSKEECSSTLAVWVKWPVHPSAPDLAGNKRQFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKSSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSVCFQMTVLRDLEKLAGWHRIAIIYLLSGITGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFAFGLLPWIDNFAHISGFVSGLFLSFAFLPYISFGKFDLYRKRCQIIIFQVVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTDKFCEKYELDAQLH
uniprot
proteins
function
FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. Regulator of proteosomal assembly by promoting formation of the proteosome assembly chaperone PSMG1-PSMG2 heterodimer, positively regulating proteosome activity (By similarity). {ECO:0000250|UniProtKB:Q96CC6}.
uniprot
proteins
mass_dalton
97292
uniprot
proteins
protein_family
Peptidase S54 family
uniprot
proteins
pubmed
11157800
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21439629
uniprot
proteins
pubmed
8318735
uniprot
proteins
sequence_length
856
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96CC6}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q96CC6}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly localized in the endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q96CC6}.
uniprot
proteins
transmembrane_region
TRANSMEM 413..433; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 657..677; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 693..713; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 716..736; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 748..768; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 774..794; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 805..825; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins