Thap4
entrez
67026
canonical
uniprot
Q6P3Z3
canonical
ensembl
ENSMUSG00000026279
resolver
ensp
ENSMUSP00000140761
resolver
ensp
ENSMUSP00000143943
resolver
enst
ENSMUST00000189728
resolver
genesymbol
Thap4
resolver
uniprot
A0A0J9YU08
resolver
uniprot
Q3US28
resolver
uniprot
Q6NZN6
resolver
uniprot
Q6PEN6
resolver
uniprot
Q91WR2
resolver
uniprot
Q9CVE5
resolver
uniprot
Q9CVG3
resolver
uniprot_entry
A0A0J9YU08_MOUSE
resolver
uniprot_entry
THAP4_MOUSE
resolver
uniprot_sec
Q3US28
resolver
uniprot_sec
Q6NZN6
resolver
uniprot_sec
Q6PEN6
resolver
uniprot_sec
Q91WR2
resolver
uniprot_sec
Q9CVE5
resolver
uniprot_sec
Q9CVG3
resolver
amino_acid_sequence
MVICCAAVNCSNRQGKGEKRAVSFHRFPLKDSKRLIQWLKAVQRDNWTPTKYSFLCSEHFTKDSFSKRLEDQHRLLKPTAVPSIFHLSEKKRGAGGHGHARRKTTAAMRGHTSAETGKGTIGSSLSSSDNLMAKPESRKLKRASPQDDAAPKVTPGAVSQEQGQSLEKTPGDDPAAPLARGQEEAQASATEADHQKASSSTDAEGADKSGISMDDFTPPGSGACKFIGSLHSYSFSSKHTRERPSVPREPMDRKRLKREMEPRCSGNSVAQSPPSSSLTATPQKASQSPSAPPTDVTPKPAAEAVQSEHSDASPMSINEVILSASGACKLIDSLHSYCFSARQNKSQVCCLREQVEKKNGELKSLRQKVSRSDSQVRKLREKLDELRRASLPYLPYLSGLLPPSHEPPKLNPVVEPLSWMLGTWLSDPPGVGTFPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPETHKPMHRECGFIRLKPDTNKVAFVSAQNTGIVEVEEGEVNGQELCVSSHSVSRISFAKEPHVEQITRKFRLNSEGKLEQTVSMATTTQPMTQHLHITYKKVTP
uniprot
proteins
ec_number
5.99.-.-
uniprot
proteins
function
FUNCTION: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region. {ECO:0000250|UniProtKB:Q8WY91}.
uniprot
proteins
mass_dalton
62571
uniprot
proteins
pathway_participation
PATHWAY: Nitrogen metabolism. {ECO:0000250|UniProtKB:Q8WY91}.
uniprot
proteins
protein_family
Nitrobindin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
569
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8WY91}. Nucleus {ECO:0000250|UniProtKB:Q8WY91}. Note=Localizes mainly in the cytoplasm and partially in the nucleus. {ECO:0000250|UniProtKB:Q8WY91}.
uniprot
proteins