Ercc4
entrez
50505
canonical
uniprot
Q9QZD4
canonical
ensembl
ENSMUSG00000022545
resolver
ensp
ENSMUSP00000023206
resolver
enst
ENSMUST00000023206
resolver
genesymbol
Ercc4
resolver
genesymbol_syn
Xpf
resolver
uniprot
O54810
resolver
uniprot
Q3UEU6
resolver
uniprot
Q8R0I3
resolver
uniprot_entry
Q3UEU6_MOUSE
resolver
uniprot_entry
XPF_MOUSE
resolver
uniprot_sec
O54810
resolver
uniprot_sec
Q8R0I3
resolver
amino_acid_sequence
MEPGLSGERRSMAPLLEYERQQVLELLDSDGLVVCARGLGTDRLLYHFLRLHCHPACLVLVLNTQPAEEEYFINQLKIEGVEHLPRRVTNEIASNSRYEVYTQGGIIFATSRILVVDFLTGRIPSDLITGILVYRAHRIIESCQEAFILRLFRQKNKRGFIKAFTDNAVAFDTGFCHVERVMRNLFVRKLYLWPRFHVAVNSFLEQHKPEVVEIHVSMTPAMLAIQTAILDILNACLKELKCHNPSLEVEDLSLENALGKPFDKTIRHYLDPLWHQLGAKTKSLVQDLKILRTLLQYLSQYDCVTFLNLLESLRATEKVFGQNSGWLFLDASTSMFVNARARVYRVPDVKLNKKAKTSEKTSSPEVQETKKELVLESNPKWEALTDVLKEIEAENKESEALGGPGRVLICASDDRTCCQLRDYLSAGAETFLLRLYRKTFEKDGKAEEVWVNVRKGDGPKRTTKSDKRPKAAPNKERASAKRGAPLKRKKQELTLTQVLGSAEEPPEDKALEEDLCRQTSSSPEGCGVEIKRESFDLNVSSDAAYGILKEPLTIIHPLLGCSDPYALTRVLHEVEPRYVVLYDAELTFVRQLEIYRASRPGKPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIREKASMVVPEEREGRDETNLDLARGSAALDAPTDTRKAGGQEQNGTQSSIVVDMREFRSELPSLIHRRGIDIEPVTLEVGDYILTPELCVERKSVSDLIGSLHSGRLYSQCLAMSRYYRRPVLLIEFDPSKPFSLAPRGAFFQEMSSSDVSSKLTLLTLHFPRLRLLWCPSPHATAELFEELKQNKPQPDAATAMAITADSETLPESDRYNPGPQDFVLKMPGVNAKNCRSLMNQVKNIAELATLSLERLTTILGHSGNAKQLHDFLHTAYADLVSKGRVRK
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair. {ECO:0000250|UniProtKB:Q92889}.
uniprot
proteins
mass_dalton
103690
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-912 by KAT5 promotes interaction with ERCC1 by disrupting a salt bridge between Asp-908 and Lys-912, thereby exposing a second binding site for ERCC1 (By similarity). Deacetylated by SIRT1 (By similarity). {ECO:0000250|UniProtKB:Q92889}.
uniprot
proteins
protein_family
XPF family
uniprot
proteins
pubmed
10644440
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
917
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92889}. Chromosome {ECO:0000250|UniProtKB:Q92889}. Note=Localizes to sites of DNA damage. {ECO:0000250|UniProtKB:Q92889}.
uniprot
proteins