KLHDC3
entrez
116138
canonical
uniprot
Q9BQ90
canonical
ensembl
ENSG00000124702
resolver
ensp
ENSP00000313995
resolver
ensp
ENSP00000562852
resolver
ensp
ENSP00000562853
resolver
ensp
ENSP00000562855
resolver
ensp
ENSP00000562856
resolver
ensp
ENSP00000562858
resolver
ensp
ENSP00000562859
resolver
ensp
ENSP00000562861
resolver
ensp
ENSP00000562862
resolver
ensp
ENSP00000562863
resolver
ensp
ENSP00000562864
resolver
ensp
ENSP00000601115
resolver
ensp
ENSP00000601116
resolver
ensp
ENSP00000601117
resolver
ensp
ENSP00000601118
resolver
ensp
ENSP00000601119
resolver
ensp
ENSP00000601120
resolver
ensp
ENSP00000601122
resolver
ensp
ENSP00000601123
resolver
ensp
ENSP00000635830
resolver
enst
ENST00000326974
resolver
enst
ENST00000892793
resolver
enst
ENST00000892794
resolver
enst
ENST00000892796
resolver
enst
ENST00000892797
resolver
enst
ENST00000892799
resolver
enst
ENST00000892800
resolver
enst
ENST00000892802
resolver
enst
ENST00000892803
resolver
enst
ENST00000892804
resolver
enst
ENST00000892805
resolver
enst
ENST00000931056
resolver
enst
ENST00000931057
resolver
enst
ENST00000931058
resolver
enst
ENST00000931059
resolver
enst
ENST00000931060
resolver
enst
ENST00000931061
resolver
enst
ENST00000931063
resolver
enst
ENST00000931064
resolver
enst
ENST00000965771
resolver
genesymbol
KLHDC3
resolver
genesymbol_syn
PEAS
resolver
hgnc
HGNC:20704
resolver
uniprot
A8K2W9
resolver
uniprot_entry
KLDC3_HUMAN
resolver
uniprot_sec
A8K2W9
resolver
amino_acid_sequence
MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29775578, PubMed:29779948). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29775578, PubMed:29779948). The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons (PubMed:29775578, PubMed:29779948). The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine (PubMed:26138980). May be involved in meiotic recombination process (PubMed:12606021). {ECO:0000269|PubMed:12606021, ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948}.
uniprot
proteins
mass_dalton
43088
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948}.
uniprot
proteins
pubmed
12606021
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26138980
uniprot
proteins
pubmed
29775578
uniprot
proteins
pubmed
29779948
uniprot
proteins
pubmed
36805027
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12606021}.
uniprot
proteins