TRIB3
entrez
57761
canonical
uniprot
Q96RU7
canonical
ensembl
ENSG00000101255
resolver
ensp
ENSP00000217233
resolver
ensp
ENSP00000391873
resolver
ensp
ENSP00000415416
resolver
ensp
ENSP00000478194
resolver
ensp
ENSP00000519693
resolver
ensp
ENSP00000519694
resolver
ensp
ENSP00000519696
resolver
ensp
ENSP00000519697
resolver
ensp
ENSP00000553856
resolver
ensp
ENSP00000553857
resolver
ensp
ENSP00000553859
resolver
ensp
ENSP00000553860
resolver
ensp
ENSP00000600202
resolver
ensp
ENSP00000600203
resolver
ensp
ENSP00000639479
resolver
enst
ENST00000217233
resolver
enst
ENST00000422053
resolver
enst
ENST00000449710
resolver
enst
ENST00000615226
resolver
enst
ENST00000714424
resolver
enst
ENST00000714425
resolver
enst
ENST00000714427
resolver
enst
ENST00000714428
resolver
enst
ENST00000883797
resolver
enst
ENST00000883798
resolver
enst
ENST00000883800
resolver
enst
ENST00000883801
resolver
enst
ENST00000930143
resolver
enst
ENST00000930144
resolver
enst
ENST00000969420
resolver
genesymbol
TRIB3
resolver
genesymbol_syn
C20orf97
resolver
genesymbol_syn
NIPK
resolver
genesymbol_syn
SKIP3
resolver
genesymbol_syn
TRB3
resolver
hgnc
HGNC:16228
resolver
uniprot
B4DMM9
resolver
uniprot
J3KR25
resolver
uniprot
Q53GU4
resolver
uniprot
Q53ZW7
resolver
uniprot
Q6I9Y9
resolver
uniprot
Q8TAI6
resolver
uniprot
Q9H5M8
resolver
uniprot
Q9NUD2
resolver
uniprot_entry
B4DMM9_HUMAN
resolver
uniprot_entry
J3KR25_HUMAN
resolver
uniprot_entry
TRIB3_HUMAN
resolver
uniprot_sec
Q53GU4
resolver
uniprot_sec
Q53ZW7
resolver
uniprot_sec
Q6I9Y9
resolver
uniprot_sec
Q8TAI6
resolver
uniprot_sec
Q9H5M8
resolver
uniprot_sec
Q9NUD2
resolver
amino_acid_sequence
MRATPLAAPAGSLSRKKRLELDDNLDTERPVQKRARSGPQPRLPPCLLPLSPPTAPDRATAVATASRLGPYVLLEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVVPDGLGLDEAREEEGDREVVLYG
uniprot
proteins
function
FUNCTION: Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (PubMed:15775988, PubMed:15781252). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (PubMed:15775988, PubMed:15781252). May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (PubMed:15775988, PubMed:15781252). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (By similarity). Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (By similarity). May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity (PubMed:12736262). Interacts with MAPK kinases and regulates activation of MAP kinases (PubMed:15299019). Can inhibit APOBEC3A editing of nuclear DNA (PubMed:22977230). {ECO:0000250|UniProtKB:Q8K4K2, ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:15781252, ECO:0000269|PubMed:22977230}.
uniprot
proteins
mass_dalton
39578
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tribbles subfamily
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12736262
uniprot
proteins
pubmed
12743605
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15299019
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15775988
uniprot
proteins
pubmed
15781252
uniprot
proteins
pubmed
16129579
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17872950
uniprot
proteins
pubmed
22977230
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
358
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22977230}.
uniprot
proteins