O54901
uniprot
O54901
canonical
amino_acid_sequence
MGSLVFRRPFCHLSTYSLIWGMAAVALSTAQVEVVTQDERKALHTTASLRCSLKTSQEPLIVTWQKKKAVSPENMVTYSKTHGVVIQPAYKDRINVTELGLWNSSITFWNTTLEDEGCYMCLFNTFGSQKVSGTACLTLYVQPIVHLHYNYFEDHLNITCSATARPAPAISWKGTGTGIENSTESHFHSNGTTSVTSILRVKDPKTQVGKEVICQVLYLGNVIDYKQSLDKGFWFSVPLLLSIVSLVILLVLISILLYWKRHRNQERGESSQGMQRMK
uniprot
proteins
function
FUNCTION: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
31256
uniprot
proteins
mutagenesis
MUTAGEN 37; /note="Q->K: No effect on binding to CD200R."; /evidence="ECO:0000269|PubMed:23602662"; MUTAGEN 57; /note="Q->K: Enhances binding to CD200R."; /evidence="ECO:0000269|PubMed:23602662"; MUTAGEN 60; /note="L->K: Abolishes binding to CD200R."; /evidence="ECO:0000269|PubMed:23602662"; MUTAGEN 61; /note="I->E: Abolishes binding to CD200R."; /evidence="ECO:0000269|PubMed:23602662"; MUTAGEN 74; /note="N->A: Abolishes binding to CD200R."; /evidence="ECO:0000269|PubMed:23602662"; MUTAGEN 122; /note="L->A: Abolishes binding to CD200R."; /evidence="ECO:0000269|PubMed:23602662"; MUTAGEN 124; /note="N->K: Abolishes binding to CD200R."; /evidence="ECO:0000269|PubMed:23602662"; MUTAGEN 126; /note="F->D: Abolishes binding to CD200R."; /evidence="ECO:0000269|PubMed:23602662
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23602662
uniprot
proteins
pubmed
9434094
uniprot
proteins
pubmed
9457671
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 233..259; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins