MTFP1
entrez
51537
canonical
uniprot
Q9UDX5
canonical
ensembl
ENSG00000242114
resolver
ensp
ENSP00000266263
resolver
ensp
ENSP00000347267
resolver
genesymbol
MTFP1
resolver
genesymbol_syn
MTP18
resolver
hgnc
HGNC:26945
resolver
uniprot
A6NFQ5
resolver
uniprot
Q9H3K1
resolver
uniprot
Q9P0N6
resolver
uniprot_entry
MTFP1_HUMAN
resolver
uniprot_sec
A6NFQ5
resolver
uniprot_sec
Q9H3K1
resolver
uniprot_sec
Q9P0N6
resolver
amino_acid_sequence
MSEPQPRGAERDLYRDTWVRYLGYANEVGEAFRSLVPAAVVWLSYGVASSYVLADAIDKGKKAGEVPSPEAGRSARVTVAVVDTFVWQALASVAIPGFTINRVCAASLYVLGTATRWPLAVRKWTTTALGLLTIPIIIHPIDRSVDFLLDSSLRKLYPTVGKPSSS
uniprot
proteins
function
FUNCTION: Plays a role in the regulation of mitochondrial morphology (PubMed:15155745, PubMed:15985469). Inhibits mitochondrial fusion by creating a non-fusogenic lipid environment which affects OPA1 oligomerization and its subsequent capacity to drive fusion (PubMed:38851188). This prevents defective inner mitochondrial membrane (IMM) subdomains from fusing with other mitochondria, facilitating their segregation into small MTFP1-enriched mitochondria (SMEM) which are targeted for autophagic degradation (PubMed:38851188, PubMed:41398051). This IMM quality control mechanism controls mitochondrial DNA levels (PubMed:38851188). {ECO:0000269|PubMed:15155745, ECO:0000269|PubMed:15985469, ECO:0000269|PubMed:38851188, ECO:0000269|PubMed:41398051}.
uniprot
proteins
mass_dalton
18010
uniprot
proteins
protein_family
MTFP1 family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
15155745
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15985469
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
38851188
uniprot
proteins
pubmed
41398051
uniprot
proteins
sequence_length
166
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:38851188, ECO:0000305|PubMed:15155745, ECO:0000305|PubMed:15985469}; Multi-pass membrane protein {ECO:0000255}. Note=Assembles into discrete subdomains known as small MTFP1-enriched mitochondria (SMEM). {ECO:0000269|PubMed:38851188, ECO:0000269|PubMed:41398051}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 80..100; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 129..149; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins