Kcnk10
entrez
65272
canonical
uniprot
Q9JIS4
canonical
ensembl
ENSRNOG00000003813
resolver
ensembl
ENSRNOG00055015349
resolver
ensembl
ENSRNOG00060005081
resolver
ensembl
ENSRNOG00065014345
resolver
ensp
ENSRNOP00000005175
resolver
ensp
ENSRNOP00000092512
resolver
ensp
ENSRNOP00000107366
resolver
ensp
ENSRNOP00055021353
resolver
ensp
ENSRNOP00060006348
resolver
ensp
ENSRNOP00065018425
resolver
enst
ENSRNOT00000005175
resolver
enst
ENSRNOT00000111719
resolver
enst
ENSRNOT00000141601
resolver
enst
ENSRNOT00055026257
resolver
enst
ENSRNOT00060008469
resolver
enst
ENSRNOT00065023671
resolver
genesymbol
Kcnk10
resolver
genesymbol_syn
Trek2
resolver
uniprot
A0A8I6AHS2
resolver
uniprot
A0ABK0LQG5
resolver
uniprot
Q548D8
resolver
uniprot_entry
A0A8I6AHS2_RAT
resolver
uniprot_entry
A0ABK0LQG5_RAT
resolver
uniprot_entry
KCNKA_RAT
resolver
uniprot_sec
Q548D8
resolver
activity_regulation
ACTIVITY REGULATION: Activated by stimuli such as mechanical stretch, acidic pH and polyunsaturated free fatty acids. {ECO:0000269|PubMed:10747911}.
uniprot
proteins
amino_acid_sequence
MKFPIETPRKQVNWDPKVAVPAAAPPVCQPKSATNGHHPVPRLSISSRATVVARMEGASQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHICVSPQELETLIQHALDADNAGVSPVGNSSNSSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIINKFGSTSKLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEDETEKMCNSDNSSTAMLTECIQQQAEMENGMVPMDTKDQGLENNSLLEDRN
uniprot
proteins
function
FUNCTION: K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). In trigeminal ganglia sensory neurons, the heterodimer of KCNK10/TREK-2 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). Permeable to other monovalent ions such as Rb(+) and Cs(+) (By similarity) (PubMed:10747911). {ECO:0000250|UniProtKB:P57789, ECO:0000250|UniProtKB:Q8BUW1, ECO:0000269|PubMed:10747911}.
uniprot
proteins
mass_dalton
59801
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
10747911
uniprot
proteins
pubmed
11897838
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BUW1}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 182..202; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 234..254; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 299..319; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins