CMTR1
entrez
23070
canonical
uniprot
Q8N1G2
canonical
ensembl
ENSG00000137200
resolver
ensp
ENSP00000362550
resolver
ensp
ENSP00000527689
resolver
ensp
ENSP00000527696
resolver
ensp
ENSP00000527697
resolver
enst
ENST00000373451
resolver
enst
ENST00000857630
resolver
enst
ENST00000857637
resolver
enst
ENST00000857638
resolver
genesymbol
CMTR1
resolver
genesymbol_syn
FTSJD2
resolver
genesymbol_syn
KIAA0082
resolver
genesymbol_syn
MTR1
resolver
hgnc
HGNC:21077
resolver
uniprot
A8K949
resolver
uniprot
Q14670
resolver
uniprot
Q96FJ9
resolver
uniprot_entry
CMTR1_HUMAN
resolver
uniprot_sec
A8K949
resolver
uniprot_sec
Q14670
resolver
uniprot_sec
Q96FJ9
resolver
amino_acid_sequence
MKRRTDPECTAPIKKQKKRVAELALSLSSTSDDEPPSSVSHGAKASTTSLSGSDSETEGKQHSSDSFDDAFKADSLVEGTSSRYSMYNSVSQKLMAKMGFREGEGLGKYSQGRKDIVEASSQKGRRGLGLTLRGFDQELNVDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKRKMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTRANPYEMIRGVFFLNRAAMKMANMDFVFDRMFTNPRDSYGKPLVKDREAELLYFADVCAGPGGFSEYVLWRKKWHAKGFGMTLKGPNDFKLEDFYSASSELFEPYYGEGGIDGDGDITRPENISAFRNFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQLLLCQFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLLYCCFERVCLFKPITSRPANSERYVVCKGLKVGIDDVRDYLFAVNIKLNQLRNTDSDVNLVVPLEVIKGDHEFTDYMIRSNESHCSLQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWGIPDQARVAPSSSDPKSKFFELIQGTEIDIFSYKPTLLTSKTLEKIRPVFDYRCMVSGSEQKFLIGLGKSQIYTWDGRQSDRWIKLDLKTELPRDTLLSVEIVHELKGEGKAQRKISAIHILDVLVLNGTDVREQHFNQRIQLAEKFVKAVSKPSRPDMNPIRVKEVYRLEEMEKIFVRLEMKIIKGSSGTPKLSYTGRDDRHFVPMGLYIVRTVNEPWTMGFSKSFKKKFFYNKKTKDSTFDLPADSIAPFHICYYGRLFWEWGDGIRVHDSQKPQDQDKLSKEDVLSFIQMHRA
uniprot
proteins
ec_number
2.1.1.57
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}.
uniprot
proteins
mass_dalton
95321
uniprot
proteins
mutagenesis
MUTAGEN 203; /note="K->A: Reduces both mRNA cap binding and catalytic activity of the enzyme."; /evidence="ECO:0000269|PubMed:24402442"; MUTAGEN 228; /note="R->A: No effect."; /evidence="ECO:0000269|PubMed:24402442"; MUTAGEN 239; /note="K->A: Abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:21310715"; MUTAGEN 364; /note="D->A: Abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:21310715"; MUTAGEN 404; /note="K->A: Abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:21310715
uniprot
proteins
pubmed
12743294
uniprot
proteins
pubmed
12743306
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18533109
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20713356
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21310715
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24402442
uniprot
proteins
pubmed
7788527
uniprot
proteins
sequence_length
835
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:21310715}.
uniprot
proteins