Rnf121
entrez
75212
canonical
uniprot
Q8R1Z9
canonical
ensembl
ENSMUSG00000070426
resolver
ensp
ENSMUSP00000086453
resolver
ensp
ENSMUSP00000094396
resolver
enst
ENSMUST00000089052
resolver
genesymbol
Rnf121
resolver
uniprot
K4DI70
resolver
uniprot
Q3TXH5
resolver
uniprot
Q8BP06
resolver
uniprot
Q8BSB1
resolver
uniprot
Q9D4X4
resolver
uniprot_entry
K4DI70_MOUSE
resolver
uniprot_entry
RN121_MOUSE
resolver
uniprot_sec
Q3TXH5
resolver
uniprot_sec
Q8BP06
resolver
uniprot_sec
Q8BSB1
resolver
uniprot_sec
Q9D4X4
resolver
amino_acid_sequence
MAAVVEVEVGGGALAERELDEVDMSDLSPEEQWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNMVTLFQMWVVPLYFTVKLHWWRFLVIWIFFSAVTAFVTFRATRKPLVQTTPRLVYKWFLLIYKISYATGIVGYMAVMFTLFGLNLLFKIKPEDAMDFGISLLFYGLYYGVLERDFAEMCADYMASTIGFYSESGMPTKHLSDSVCAVCGQQIFVDVNEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGLVQGISYILGLE
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase which accepts ubiquitin and transfers it to substrates thereby promoting their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway which is a pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (By similarity). May regulate the unfolded protein response to reduce endoplasmic reticulum stress (By similarity). {ECO:0000250|UniProtKB:Q09251}.
uniprot
proteins
mass_dalton
37987
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q09251}.
uniprot
proteins
protein_family
RNF121 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q09251}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 50..70; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 148..168; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 306..326; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins