NPTN
entrez
27020
canonical
uniprot
Q9Y639
canonical
ensembl
ENSG00000156642
resolver
ensp
ENSP00000290401
resolver
ensp
ENSP00000342958
resolver
ensp
ENSP00000456349
resolver
ensp
ENSP00000457028
resolver
ensp
ENSP00000709577
resolver
genesymbol
NPTN
resolver
genesymbol_syn
SDFR1
resolver
genesymbol_syn
SDR1
resolver
hgnc
HGNC:17867
resolver
uniprot
B2RAL7
resolver
uniprot
B7Z4D3
resolver
uniprot
B7ZLL2
resolver
uniprot
Q17R52
resolver
uniprot
Q59EJ9
resolver
uniprot
Q6NVX7
resolver
uniprot
Q9Y640
resolver
uniprot_entry
NPTN_HUMAN
resolver
uniprot_sec
B2RAL7
resolver
uniprot_sec
B7Z4D3
resolver
uniprot_sec
B7ZLL2
resolver
uniprot_sec
Q17R52
resolver
uniprot_sec
Q59EJ9
resolver
uniprot_sec
Q6NVX7
resolver
uniprot_sec
Q9Y640
resolver
amino_acid_sequence
MSGSSLPSALALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLTGDAFELYCDVVGSPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGVSVLRITRLTLEDSGTYECRASNDPKRNDLRQNPSITWIRAQATISVLQKPRIVTSEEVIIRDSPVLPVTLQCNLTSSSHTLTYSYWTKNGVELSATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDIVNTSGRFFIINKENYTELNIVNLQITEDPGEYECNATNAIGSASVVTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTNNHKDKNLRQRNTN
uniprot
proteins
function
FUNCTION: Accessory subunit of plasma membrane calcium-transporting ATPase ATP2B2/PMCA2 that stabilizes the transporter at the cell surface (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed:30190470). Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK (By similarity). May also regulate neurite outgrowth by activating the FGFR1 signaling pathway (By similarity). May play a role in synaptic plasticity (By similarity). Promotes localization of XKR8 at the cell membrane (PubMed:27503893). {ECO:0000250|UniProtKB:P97300, ECO:0000250|UniProtKB:P97546, ECO:0000269|PubMed:27503893, ECO:0000269|PubMed:30190470}.
uniprot
proteins
mass_dalton
44387
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17196182
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
27503893
uniprot
proteins
pubmed
30190470
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P97300}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P97300}.; SUBCELLULAR LOCATION: [Isoform 2]: Postsynaptic density {ECO:0000250|UniProtKB:P97546}.
uniprot
proteins
transmembrane_region
TRANSMEM 340..360; /note="Helical"; /evidence="ECO:0000269|PubMed:30190470, ECO:0007744|PDB:6A69
uniprot
proteins