STK38
entrez
11329
canonical
uniprot
Q15208
canonical
ensembl
ENSG00000112079
resolver
ensp
ENSP00000229812
resolver
ensp
ENSP00000520947
resolver
ensp
ENSP00000539194
resolver
ensp
ENSP00000539195
resolver
ensp
ENSP00000539198
resolver
ensp
ENSP00000640415
resolver
ensp
ENSP00000665765
resolver
ensp
ENSP00000665766
resolver
ensp
ENSP00000693835
resolver
enst
ENST00000229812
resolver
enst
ENST00000850860
resolver
enst
ENST00000869135
resolver
enst
ENST00000869136
resolver
enst
ENST00000869139
resolver
enst
ENST00000970356
resolver
genesymbol
STK38
resolver
genesymbol_syn
NDR1
resolver
hgnc
HGNC:17847
resolver
uniprot
Q503A1
resolver
uniprot_entry
STK38_HUMAN
resolver
uniprot_sec
Q503A1
resolver
activity_regulation
ACTIVITY REGULATION: Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38. {ECO:0000269|PubMed:12493777, ECO:0000269|PubMed:14661952, ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:15197186}.
uniprot
proteins
amino_acid_sequence
MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKAAK
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (PubMed:32537488). {ECO:0000269|PubMed:12493777, ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:17906693, ECO:0000269|PubMed:32537488, ECO:0000269|PubMed:7761441}.
uniprot
proteins
mass_dalton
54190
uniprot
proteins
mutagenesis
MUTAGEN 74; /note="T->A: Decreases autophosphorylation and kinase activity. Reduced binding of S100B."; /evidence="ECO:0000269|PubMed:12493777"; MUTAGEN 118; /note="K->A: Loss of autophosphorylation and kinase activity."; /evidence="ECO:0000269|PubMed:12493777, ECO:0000269|PubMed:7761441"; MUTAGEN 281; /note="S->A: Loss of autophosphorylation and kinase activity."; /evidence="ECO:0000269|PubMed:12493777"; MUTAGEN 306..311; /note="WSLGVI->ASAGAA: Abolished binding to ufmylated histone H4."; /evidence="ECO:0000269|PubMed:32537488"; MUTAGEN 444; /note="T->A: Decreases autophosphorylation and kinase activity."; /evidence="ECO:0000269|PubMed:12493777
uniprot
proteins
post_translational_modification
PTM: ISGylated. {ECO:0000305|PubMed:16884686}.; PTM: Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B. {ECO:0000269|PubMed:12493777, ECO:0000269|PubMed:18362890}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
12493777
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14661952
uniprot
proteins
pubmed
15067004
uniprot
proteins
pubmed
15197186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16884686
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17906693
uniprot
proteins
pubmed
18362890
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19377461
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24336203
uniprot
proteins
pubmed
32537488
uniprot
proteins
pubmed
7761441
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12493777, ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:7761441}. Cytoplasm {ECO:0000269|PubMed:17906693, ECO:0000269|PubMed:7761441}. Chromosome {ECO:0000269|PubMed:32537488}. Note=Localizes to DNA double-strand breaks in response to DNA damage. {ECO:0000269|PubMed:32537488}.
uniprot
proteins