TNFRSF10B
entrez
8795
canonical
uniprot
O14763
canonical
ensembl
ENSG00000120889
resolver
ensp
ENSP00000276431
resolver
ensp
ENSP00000317859
resolver
genesymbol
TNFRSF10B
resolver
genesymbol_syn
DR5
resolver
genesymbol_syn
KILLER
resolver
genesymbol_syn
TRAILR2
resolver
genesymbol_syn
TRICK2
resolver
genesymbol_syn
ZTNFR9
resolver
hgnc
HGNC:11905
resolver
uniprot
O14720
resolver
uniprot
O15508
resolver
uniprot
O15517
resolver
uniprot
O15531
resolver
uniprot
Q6UXM8
resolver
uniprot
Q7Z360
resolver
uniprot
Q9BVE0
resolver
uniprot_entry
TR10B_HUMAN
resolver
uniprot_sec
O14720
resolver
uniprot_sec
O15508
resolver
uniprot_sec
O15517
resolver
uniprot_sec
O15531
resolver
uniprot_sec
Q6UXM8
resolver
uniprot_sec
Q7Z360
resolver
uniprot_sec
Q9BVE0
resolver
amino_acid_sequence
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
uniprot
proteins
disease_involvement
DISEASE: Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. {ECO:0000269|PubMed:10542098, ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:15322075}.
uniprot
proteins
mass_dalton
47878
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3. {ECO:0000269|PubMed:30902834}.
uniprot
proteins
pubmed
10072170
uniprot
proteins
pubmed
10542098
uniprot
proteins
pubmed
10549288
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15322075
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18846110
uniprot
proteins
pubmed
23498957
uniprot
proteins
pubmed
23555243
uniprot
proteins
pubmed
30902834
uniprot
proteins
pubmed
9242610
uniprot
proteins
pubmed
9242611
uniprot
proteins
pubmed
9285725
uniprot
proteins
pubmed
9311998
uniprot
proteins
pubmed
9325248
uniprot
proteins
pubmed
9326928
uniprot
proteins
pubmed
9373179
uniprot
proteins
pubmed
9430227
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins