ALDH1B1
entrez
219
canonical
uniprot
P30837
canonical
ensembl
ENSG00000137124
resolver
ensp
ENSP00000366927
resolver
ensp
ENSP00000567523
resolver
ensp
ENSP00000567524
resolver
ensp
ENSP00000598893
resolver
ensp
ENSP00000639542
resolver
enst
ENST00000377698
resolver
enst
ENST00000897464
resolver
enst
ENST00000897465
resolver
enst
ENST00000928834
resolver
enst
ENST00000969483
resolver
genesymbol
ALDH1B1
resolver
genesymbol_syn
ALDH5
resolver
genesymbol_syn
ALDHX
resolver
hgnc
HGNC:407
resolver
uniprot
A0A384MTJ7
resolver
uniprot
B2R8F0
resolver
uniprot
Q8WX76
resolver
uniprot
Q9BV45
resolver
uniprot_entry
A0A384MTJ7_HUMAN
resolver
uniprot_entry
AL1B1_HUMAN
resolver
uniprot_sec
B2R8F0
resolver
uniprot_sec
Q8WX76
resolver
uniprot_sec
Q9BV45
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by disulfiram. {ECO:0000269|PubMed:20616185}.
uniprot
proteins
amino_acid_sequence
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS
uniprot
proteins
ec_number
1.2.1.28
uniprot
proteins
ec_number
1.2.1.3
uniprot
proteins
ec_number
1.2.1.36
uniprot
proteins
ec_number
1.7.1.-
uniprot
proteins
function
FUNCTION: Broad specificity, mitochondrial aldehyde dehydrogenase that could play a role in the detoxification of alcohol-derived acetaldehyde and other aldehydes (PubMed:20616185, PubMed:25413692, PubMed:35788181). Shows an absolute preference for NAD(+) as no activity is detected with NADP(+) (PubMed:20616185, PubMed:25413692). Has a high affinity and catalytic efficiency toward aliphatic medium-chain saturated aldehydes relative to short-chain and aromatic aldehydes in vitro (PubMed:20616185). Also capable of metabolizing products of lipid peroxidation, namely 4-hydroxynon-2-enal(4-HNE) and malonaldehyde (MDA) but with lower catalytic efficiency (PubMed:20616185). In vitro, it can also display a nitroglycerin reductase activity (PubMed:25413692). Has also an esterase activity in vitro, but this may be not physiologically relevant in vivo (PubMed:20616185). {ECO:0000269|PubMed:20616185, ECO:0000269|PubMed:25413692, ECO:0000269|PubMed:35788181}.
uniprot
proteins
mass_dalton
57249
uniprot
proteins
pathway_participation
PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. {ECO:0000305|PubMed:20616185}.
uniprot
proteins
protein_family
Aldehyde dehydrogenase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2061311
uniprot
proteins
pubmed
20616185
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25413692
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
35788181
uniprot
proteins
pubmed
8244338
uniprot
proteins
sequence_length
517
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305|PubMed:35788181}.
uniprot
proteins