Cdca8
entrez
500545
canonical
uniprot
Q6AXW0
canonical
ensembl
ENSRNOG00000031431
resolver
ensembl
ENSRNOG00055012622
resolver
ensembl
ENSRNOG00060017142
resolver
ensembl
ENSRNOG00065017769
resolver
ensp
ENSRNOP00000043633
resolver
ensp
ENSRNOP00055017445
resolver
ensp
ENSRNOP00060023572
resolver
ensp
ENSRNOP00065023619
resolver
enst
ENSRNOT00000048293
resolver
enst
ENSRNOT00055021531
resolver
enst
ENSRNOT00060029308
resolver
enst
ENSRNOT00065029737
resolver
genesymbol
Cdca8
resolver
uniprot_entry
BOREA_RAT
resolver
amino_acid_sequence
MAPKKRSSRGTRTNTLRSRKLASFLKDFDREVQVRTKQIESDRQTLLKEVENLYNIEVLRLPKALQVMKWLDYFALGGNRQALEEAATADRDITEINNLTAEAIQTPLKSVKKRKVIEVDEAIKEEEEDEEEEGGGGGGRKSHKNLRSARVKRCPPSKKRTQSIQGRSRSKRLSHDFVTPAMSRLEPSLVKPTPGMTPRFDSRVFKTPGLRTPAAKEQVYNISINGSPLADSKEISLSVPIGGGASLRLLASDLQRVDIAQLNPEALGNIKKLSSRLAQICSSIRTGR
uniprot
proteins
function
FUNCTION: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). {ECO:0000250|UniProtKB:Q53HL2}.
uniprot
proteins
mass_dalton
32099
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by TTK, essentially at Thr-88 and Thr-94. Phosphorylation (probably by CDK1) promotes targeting of the CPC to centromeric DNA. {ECO:0000250|UniProtKB:Q53HL2}.; PTM: Sumoylated by UBE2I and RANBP2. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3 (By similarity). {ECO:0000250|UniProtKB:Q53HL2}.; PTM: Citrullinated by PADI4. {ECO:0000250|UniProtKB:Q8BHX3}.
uniprot
proteins
protein_family
Borealin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q53HL2}. Cytoplasm {ECO:0000250|UniProtKB:Q53HL2}. Chromosome, centromere {ECO:0000250|UniProtKB:Q53HL2}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q53HL2}. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. {ECO:0000250|UniProtKB:Q53HL2}.
uniprot
proteins