Kcna1
entrez
24520
canonical
uniprot
P10499
canonical
ensembl
ENSRNOG00000064052
resolver
ensembl
ENSRNOG00055010711
resolver
ensembl
ENSRNOG00060016588
resolver
ensembl
ENSRNOG00065033451
resolver
ensp
ENSRNOP00000081659
resolver
ensp
ENSRNOP00000103372
resolver
ensp
ENSRNOP00055014537
resolver
ensp
ENSRNOP00060022866
resolver
ensp
ENSRNOP00065047349
resolver
enst
ENSRNOT00000101523
resolver
enst
ENSRNOT00000169507
resolver
enst
ENSRNOT00055018095
resolver
enst
ENSRNOT00060028402
resolver
enst
ENSRNOT00065057508
resolver
genesymbol
Kcna1
resolver
uniprot_entry
KCNA1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 4-aminopyridine (4-AP) and by tetraethylammonium (TEA) (PubMed:2539643). Inhibited by kaliotoxin (KTX) (PubMed:23725331). {ECO:0000269|PubMed:2348860, ECO:0000269|PubMed:23725331, ECO:0000269|PubMed:2539643}.
uniprot
proteins
amino_acid_sequence
MTVMSGENADEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTIHRIDNTTVIYTSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTISKSEYMEIEEDMNNSIAHYRQANIRTGNCTATDQNCVNKSKLLTDV
uniprot
proteins
function
FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:12177193, PubMed:17855588, PubMed:22206926). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:23725331). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2539643). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:10896669, PubMed:12177193, PubMed:2348860, PubMed:23725331). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (PubMed:10896669, PubMed:12114518). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA1 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:12681381, PubMed:22206926, PubMed:2348860, PubMed:23725331, PubMed:8038169). In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:2348860). Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability. Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons (PubMed:12177193, PubMed:23318870). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (PubMed:16306173). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) release (PubMed:17869444). Plays a role in regulating the generation of action potentials and preventing hyperexcitability in myelinated axons of the vagus nerve, and thereby contributes to the regulation of heart contraction (By similarity). Required for normal neuromuscular responses (PubMed:22206926). Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception of pain due to heat stimuli (By similarity). Required for normal responses to auditory stimuli and precise location of sound sources, but not for sound perception (By similarity). The use of toxins that block specific channels suggest that it contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain (By similarity). Plays a role in the reabsorption of Mg(2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (By similarity). {ECO:0000250|UniProtKB:P16388, ECO:0000250|UniProtKB:Q09470, ECO:0000269|PubMed:10896669, ECO:0000269|PubMed:12114518, ECO:0000269|PubMed:12177193, ECO:0000269|PubMed:12681381, ECO:0000269|PubMed:17855588, ECO:0000269|PubMed:17869444, ECO:0000269|PubMed:22206926, ECO:0000269|PubMed:23318870, ECO:0000269|PubMed:2348860, ECO:0000269|PubMed:23725331, ECO:0000269|PubMed:2539643, ECO:0000269|PubMed:8038169, ECO:0000305|PubMed:16306173}.
uniprot
proteins
mass_dalton
56379
uniprot
proteins
mutagenesis
MUTAGEN 309; /note="S->T: In ADMS: Dominant negative mutation that abolishes channel activity; leads to myokymia, neuromyotonia, spontaneous epileptic seizures and premature death."; /evidence="ECO:0000269|PubMed:22206926"; MUTAGEN 352; /note="A->R: Is not blocked by the scorpion mesomartoxin."; /evidence="ECO:0000269|PubMed:25514171"; MUTAGEN 355; /note="H->Q: Is not blocked by the scorpion mesomartoxin."; /evidence="ECO:0000269|PubMed:25514171"; MUTAGEN 357; /note="S->P: Is not blocked by the scorpion mesomartoxin."; /evidence="ECO:0000269|PubMed:25514171"; MUTAGEN 379; /note="Y->V: Is blocked by the scorpion mesomartoxin, with an IC(50)=16.60 nM."; /evidence="ECO:0000269|PubMed:25514171"; MUTAGEN 381; /note="V->T: Is not blocked by the scorpion mesomartoxin."; /evidence="ECO:0000269|PubMed:25514171"; MUTAGEN 443; /note="R->C: Abolishes phosphorylation by PKA; when associated with A-446."; MUTAGEN 446; /note="S->A: Abolishes phosphorylation by PKA; when associated with C-443.
uniprot
proteins
post_translational_modification
PTM: Palmitoylated on Cys-243; which may be required for membrane targeting. {ECO:0000250|UniProtKB:Q09470}.; PTM: N-glycosylated. {ECO:0000269|PubMed:10896669, ECO:0000269|PubMed:8038169}.; PTM: Phosphorylated on tyrosine residues. Phosphorylation increases in response to NRG1; this inhibits channel activity (By similarity). Phosphorylated by PKA (PubMed:12681381, PubMed:8038169). Phosphorylation at Ser-446 regulates channel activity by down-regulating expression at the cell membrane (By similarity). {ECO:0000250|UniProtKB:P16388, ECO:0000250|UniProtKB:Q09470, ECO:0000269|PubMed:12681381, ECO:0000269|PubMed:8038169}.
uniprot
proteins
protein_family
A (Shaker) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv1.1/KCNA1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10884227
uniprot
proteins
pubmed
10896669
uniprot
proteins
pubmed
11086297
uniprot
proteins
pubmed
12114518
uniprot
proteins
pubmed
12177193
uniprot
proteins
pubmed
12681381
uniprot
proteins
pubmed
12777451
uniprot
proteins
pubmed
12907802
uniprot
proteins
pubmed
16306173
uniprot
proteins
pubmed
16504945
uniprot
proteins
pubmed
17855588
uniprot
proteins
pubmed
17869444
uniprot
proteins
pubmed
17917103
uniprot
proteins
pubmed
20805574
uniprot
proteins
pubmed
21483673
uniprot
proteins
pubmed
22206926
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23318870
uniprot
proteins
pubmed
2348860
uniprot
proteins
pubmed
23725331
uniprot
proteins
pubmed
2539643
uniprot
proteins
pubmed
25514171
uniprot
proteins
pubmed
3191911
uniprot
proteins
pubmed
7477295
uniprot
proteins
pubmed
8038169
uniprot
proteins
pubmed
9334400
uniprot
proteins
sequence_length
495
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12114518, ECO:0000269|PubMed:12681381, ECO:0000269|PubMed:17855588, ECO:0000269|PubMed:22206926, ECO:0000269|PubMed:2348860, ECO:0000269|PubMed:23725331, ECO:0000269|PubMed:2539643, ECO:0000269|PubMed:8038169}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:11086297, ECO:0000269|PubMed:9334400}. Cell projection, axon {ECO:0000269|PubMed:11086297, ECO:0000269|PubMed:12177193, ECO:0000269|PubMed:9334400}. Cytoplasmic vesicle {ECO:0000269|PubMed:12177193, ECO:0000269|PubMed:8038169}. Perikaryon {ECO:0000269|PubMed:12177193}. Endoplasmic reticulum {ECO:0000269|PubMed:10896669, ECO:0000269|PubMed:12681381}. Cell projection, dendrite {ECO:0000250|UniProtKB:P16388}. Cell junction {ECO:0000250|UniProtKB:P16388}. Synapse {ECO:0000250|UniProtKB:P16388}. Presynapse {ECO:0000250|UniProtKB:P16388}. Presynaptic cell membrane {ECO:0000269|PubMed:17869444}. Note=Homotetrameric KCNA1 is primarily located in the endoplasmic reticulum. Interaction with KCNA2 and KCNAB2 or with KCNA4 and KCNAB2 promotes expression at the cell membrane (PubMed:10896669). {ECO:0000250|UniProtKB:P16388, ECO:0000269|PubMed:10896669}.
uniprot
proteins
transmembrane_region
TRANSMEM 165..186; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 221..242; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 254..274; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 288..308; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 324..345; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 387..415; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:P63142
uniprot
proteins