Ceacam20
entrez
71601
canonical
uniprot
Q9D2Z1
canonical
ensembl
ENSMUSG00000070777
resolver
ensp
ENSMUSP00000092344
resolver
enst
ENSMUST00000094753
resolver
genesymbol
Ceacam20
resolver
uniprot
Q80Y42
resolver
uniprot_entry
CEA20_MOUSE
resolver
uniprot_sec
Q80Y42
resolver
amino_acid_sequence
MELAGFHCCSWTVILLSALLPTTWRPPAAAHFIHRADLLSNTQMERAPLAKLTLTVNQSTVTEQREMAVFYCNTNADNITIHWVSNNSLLVLNERMKLSADNKTLTILIVQREDSGSYLCEVQHGFEVQRSNTASLTVNYGPDPVSIKLDSGVAAGDVVEVMEGNTVNFRVEAQSSPVPAYAWYLPSDFIQPPTTGTFTIDAVSREHEGMYRCLVSNPVTNLSRLGVVKVQVLEKVTAPNIEFPTLALVENATSVTLTCKTSHQRVGVHWFLKGQPLRPSDRLTLSSQNRTLTIHGLQRDDIGPYECEVWNWGSQARSVPLKLTINYGPDQVEITQGPASGVVSTIEAMLNSSLTLYCRADSIPGARYQWTHEHSSKVLDGEQLSIEALRQEHQGIYSCTSSNDVTGLARSASVLVMVVGLQSSSMSPGAIAGIVIGILVAIALAIGLGYFLYSTKDRWTRRRSASDTTSSNTIPPTSVMQSTPESRHNKPMTVYDNTPKPEGEARGKKMWSLPRDSPEQFYEKKPPSAAPEGPRKPLPQIPKQPLMPPGPGRNEESNYEKLLNSNHSLYCKITPSA
uniprot
proteins
function
FUNCTION: Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response. {ECO:0000269|PubMed:26195794}.
uniprot
proteins
mass_dalton
63444
uniprot
proteins
mutagenesis
MUTAGEN 559; /note="Y->F: Abolishes tyrosine phosphorylation and interaction with SYK; when associated with F-570."; /evidence="ECO:0000269|PubMed:26195794"; MUTAGEN 570; /note="Y->F: Abolishes tyrosine phosphorylation and interaction with SYK; when associated with F-559."; /evidence="ECO:0000269|PubMed:26195794
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by SYK, SRC and FYN in vitro. {ECO:0000269|PubMed:26195794}.
uniprot
proteins
protein_family
CEA family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16139472
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25908210
uniprot
proteins
pubmed
26195794
uniprot
proteins
sequence_length
577
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, microvillus membrane {ECO:0000269|PubMed:25908210, ECO:0000269|PubMed:26195794}; Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:25908210, ECO:0000269|PubMed:26195794}; Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with PTPRH and CEACAM1 at the apical brush border of intestinal cells. {ECO:0000269|PubMed:25908210, ECO:0000269|PubMed:26195794}.
uniprot
proteins
transmembrane_region
TRANSMEM 431..451; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins