Inpp5e
entrez
114089
canonical
uniprot
Q9WVR1
canonical
ensembl
ENSRNOG00000019039
resolver
ensembl
ENSRNOG00055008412
resolver
ensembl
ENSRNOG00060032639
resolver
ensembl
ENSRNOG00065002087
resolver
ensembl
ENSRNOG00065028072
resolver
ensp
ENSRNOP00000073935
resolver
ensp
ENSRNOP00055011435
resolver
ensp
ENSRNOP00060046748
resolver
ensp
ENSRNOP00065001889
resolver
ensp
ENSRNOP00065039724
resolver
enst
ENSRNOT00000079882
resolver
enst
ENSRNOT00055014244
resolver
enst
ENSRNOT00060056582
resolver
enst
ENSRNOT00065002755
resolver
enst
ENSRNOT00065048434
resolver
genesymbol
Inpp5e
resolver
uniprot
A0A0G2K6T4
resolver
uniprot_entry
INP5E_RAT
resolver
uniprot_sec
A0A0G2K6T4
resolver
amino_acid_sequence
MPSKSACLRHTEAPGQLEGRMLQGQLSNPEKKLIPTSASLPAADSQSSQTNSMPPLSMPAKPSNQNLQAKANLITPQPPIRPKLERTLSLDDKGWRRRRFRGSQEDLTVQNGASPCRGSLQDSVAQSPAYSRPLPCLSTSLQEIPKPRRATGSEGGSPSLWSDCLSGMISTSLDLLHREAASGGPHSRLASLRATHTPPAMDLNIASSSLRTANKVDPEHTDYKLRMQNRLVRAHSNLGPSRPRSPLAGDDHSIHSARSSFSLLAPIRTKDIRSRSYLEGSLLASGALLGADELARYFPDRNMALFVATWNMQGQKELPASLDEFLLPTEADYTQDLYVIGVQEGCSDRREWETRLQETLGPQYVLLSSAAHGVLYMSLFIRRDLIWFCSEVEYSTVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSGDGKVAERLLDYNRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGGRVAVEAFLKQDPEVDVLALLQHDQLTREMKKGSIFKGFEEAEIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYKSRHKGDICPMKYSSCPGIKTSDHRPVYGLFRVKVRPGRDNIPLAAGKFDRELYLIGIKRRISKEIQRQEALKSQSSSAVCTVS
uniprot
proteins
ec_number
3.1.3.36
uniprot
proteins
ec_number
3.1.3.86
uniprot
proteins
function
FUNCTION: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate PtdIns (4,5)P2 and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Specific for lipid substrates, inactive towards water soluble inositol phosphates (By similarity) (PubMed:10405344). Can also remove the 5-phosphate from 1D-myo-inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) (By similarity). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity). {ECO:0000250|UniProtKB:Q9JII1, ECO:0000250|UniProtKB:Q9NRR6, ECO:0000269|PubMed:10405344}.
uniprot
proteins
mass_dalton
72040
uniprot
proteins
protein_family
4
uniprot
proteins
protein_family
5-trisphosphate 5-phosphatase type IV family
uniprot
proteins
protein_family
Inositol 1
uniprot
proteins
pubmed
10405344
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
648
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9JII1}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q9JII1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JII1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JII1}. Cell membrane {ECO:0000269|PubMed:10405344}; Peripheral membrane protein {ECO:0000269|PubMed:10405344}; Cytoplasmic side {ECO:0000269|PubMed:10405344}. Cell projection, ruffle {ECO:0000269|PubMed:10405344}. Cytoplasm {ECO:0000269|PubMed:10405344}. Nucleus {ECO:0000250|UniProtKB:Q9JII1}. Note=Peripheral membrane protein associated with Golgi stacks. {ECO:0000250|UniProtKB:Q9JII1}.
uniprot
proteins