Tmem30a
entrez
300857
canonical
uniprot
Q6AY41
canonical
ensembl
ENSRNOG00000010895
resolver
ensembl
ENSRNOG00055004654
resolver
ensembl
ENSRNOG00060018625
resolver
ensembl
ENSRNOG00065012746
resolver
ensp
ENSRNOP00000070259
resolver
ensp
ENSRNOP00000084954
resolver
ensp
ENSRNOP00055005570
resolver
ensp
ENSRNOP00060026169
resolver
ensp
ENSRNOP00065015990
resolver
enst
ENSRNOT00000085725
resolver
enst
ENSRNOT00000098005
resolver
enst
ENSRNOT00055007413
resolver
enst
ENSRNOT00060032155
resolver
enst
ENSRNOT00065020784
resolver
genesymbol
Tmem30a
resolver
genesymbol_syn
Cdc50a
resolver
uniprot
A0A0G2JXG3
resolver
uniprot_entry
A0A0G2JXG3_RAT
resolver
uniprot_entry
CC50A_RAT
resolver
amino_acid_sequence
MAMNYSAKDEVDGGPTGPPGGAAKTRRPDNTAFKQQRLPAWQPILTAGTVLPTFFIIGLIFIPIGIGIFVTSNNIREIEGNVFMYYGLSNFYQNHRRYVKSRDDSQLNGDPSALLNPSKECEPYRRNEDKPIAPCGAIANSMFNDTLELFLVANESDPKPVPILLKKKGIAWWTDKNVKFRNPPGKDSLQEKFKDTTKPVNWHKPVYELDPDDESNNGFINEDFIVWMRTAALPTFRKLYRLIERTDDLHPTLPAGQYYLNITYNYPVHFFDGRKRMILSTISWMGGKNPFLGIAYITIGSISFLLGVVLLVINHKYRNSSNTADITI
uniprot
proteins
function
FUNCTION: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:CDC50A flippase complex. ATP8A2:CDC50A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:CDC50A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF). Can also mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from ER to other membrane localizations (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
37173
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Contains high mannose-type oligosaccharides (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
CDC50/LEM3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24090084
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9NV96}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus {ECO:0000250|UniProtKB:Q9NV96}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q9NV96}. Apical cell membrane {ECO:0000250|UniProtKB:Q9NV96}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q17QL5}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q17QL5}.
uniprot
proteins
transmembrane_region
TRANSMEM 50..70; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins