Ryr3
entrez
20192
canonical
uniprot
A2AGL3
canonical
ensembl
ENSMUSG00000057378
resolver
ensp
ENSMUSP00000079503
resolver
ensp
ENSMUSP00000147250
resolver
enst
ENSMUST00000208290
resolver
genesymbol
Ryr3
resolver
uniprot
A0A140LJK7
resolver
uniprot
P70184
resolver
uniprot
P70185
resolver
uniprot
Q3V1H0
resolver
uniprot
Q4JFC4
resolver
uniprot
Q60836
resolver
uniprot
Q62175
resolver
uniprot
Q62198
resolver
uniprot
Q9QY91
resolver
uniprot_entry
A0A140LJK7_MOUSE
resolver
uniprot_entry
RYR3_MOUSE
resolver
uniprot_sec
P70184
resolver
uniprot_sec
P70185
resolver
uniprot_sec
Q3V1H0
resolver
uniprot_sec
Q4JFC4
resolver
uniprot_sec
Q60836
resolver
uniprot_sec
Q62175
resolver
uniprot_sec
Q62198
resolver
uniprot_sec
Q9QY91
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is modulated by the alkaloid ryanodine that binds to the open calcium-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by elevated cytoplasmic calcium levels in the micromolar range, by caffeine and adenine nucleotides, such as AMP and ATP. Inhibited by Mg(2+) and ruthenium red. {ECO:0000250|UniProtKB:Q9TS33}.
uniprot
proteins
amino_acid_sequence
MAEAGEGGEDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIPPDLCVCNFVLEQSLSVRALQEMLANTVENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSISNGSIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTDQNDSQHRRVFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTEDQGLLLQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDMEGMGVPEIKYGDSVCFVQHVASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQQEESQAARIIRNTTALFSQFVSGNNRTTAPVALPTEEVLQTLQDLIAYFQPPEDEMQHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNIYNSVAHFAGIVREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDVLCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSPQYKKWYFELIIDQVEPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRIPRAVASINQHLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGVRDLLGTTQFLSQASFIPCPIDTSQVVLPLHLEKIRDRLAENIHELWGMNKIELGWTYGKVRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPTVEKVSIDKIRFFRVERSYAVKSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGSGYFGRTWQPGDVVGCMINLDDASMVFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGRMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAVWFSKRLPTFVNVPKDHPHIEVVRIDGTMDSPPCLKVTHKTFGTQNSNANMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDIVASSQRSSRSNVDLEIGCLLDLAMGMLSFSANGKELGTCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPTPQCPPRLDVQTIQPVLWSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMQFHYHTLRLYSAVCALGNSRVASALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLANAKERKLMMKNEYIIPITSATRNIRLYPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTSEDHQKQSPEIPLQILKTKALSMLTEAVHCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDDDDVRQILLLIDPSVFGEHSGETEEGVEKEVTHAEEKAVEAGEKACKEAPVKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTARKTREFRSPPQEQINMLLNFHLGENCPCPEEIREELYDFHEDLLVHCGVPLEEEEEEEEDTSWTGKLCALVYKIKGPPKPEKEQPTEEEKPYPTTLKELVSQTMIRWAQENQIQDAELVRMMFNLLRRQYDSIGELLQALRKTYTISQASVNDTINLLAALGQIRSLLSVRMGREEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLEKVVTYLAGCGLQSCPMLLARGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKTEVTQDDGEEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYLCSAVLPLLTRCAPLFSGTEHCTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLSEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDLDLFRMALPCLSAIAGALPPDYLDTRITATLEKQVSVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSHSGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRENEKLRCVSQTNQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGILVSRGMKDLELDASSMEKRFAYKFLKKILKYVDAAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHIAQHQFGVDLLLSDVQVSCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPSLNRHNPLSVFNTKTPRERSILGMPDKVEDMCPDIPQLEGLMKEINDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKTDGKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDPDSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSCRDTDEEVKEHLRNNLHLQEKSDDPAVKWQLNLYKDVLRNDEPSNPEKTVERVQSISAALFHLEQVEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEAHFFEEKLVQDLAKSPRVEDEEEEETERQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEEEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQNDEFTQDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISRKEFQKAMEGLKQYTQSEIDFLLSCTEADENDMFNYVDFVERFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKSLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDSTDRPEEEEEEDEDSAYSIETEGEEEEKSFESASAFTMACVSVKRNVTKFLKRATLKNLRKQYRNVKKMSAKELVKVFFSFFWMLFVGLFQLLFTIFGGIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDVIETDRAEVTEPGVTTELVHFVKGEAGDTDIMSDLFGIHSKKEGGLKQGPEVGLGDLSEIIGKDEPPTLESTVRKKRKAQAAEMKAVHEAEGKAESEKADMEDREKEDKIKEEGQTDYLWADVTVKKTRRRGQKAEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETEDVANLWNSFNDDDEEEAMVFFVLQESTGYMAPTLRALAIVHTIISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEEAKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG
uniprot
proteins
function
FUNCTION: Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Plays a role in cellular calcium signaling. Contributes to cellular calcium ion homeostasis. Isoform 2 lacks a predicted transmembrane segment and does not form functional calcium channels by itself; however, it can form tetramers with isoforms that contain the full complement of transmembrane segments and modulate their activity. {ECO:0000269|PubMed:11500519, ECO:0000269|PubMed:11717163, ECO:0000269|PubMed:17596299, ECO:0000269|PubMed:7621815, ECO:0000269|PubMed:8702664, ECO:0000269|PubMed:9582272}.
uniprot
proteins
mass_dalton
551328
uniprot
proteins
protein_family
RYR3 subfamily
uniprot
proteins
protein_family
Ryanodine receptor (TC 1.A.3.1) family
uniprot
proteins
pubmed
11500519
uniprot
proteins
pubmed
11717163
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17596299
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19503748
uniprot
proteins
pubmed
20214899
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7621815
uniprot
proteins
pubmed
7635066
uniprot
proteins
pubmed
7876312
uniprot
proteins
pubmed
8702664
uniprot
proteins
pubmed
9582272
uniprot
proteins
sequence_length
4863
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:9582272}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 4180..4200; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 4403..4423; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 4478..4498; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 4603..4623; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 4626..4646; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 4665..4685; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 4746..4766; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins