P00787
uniprot
P00787
canonical
amino_acid_sequence
MWWSLIPLSCLLALTSAHDKPSSHPLSDDMINYINKQNTTWQAGRNFYNVDISYLKKLCGTVLGGPNLPERVGFSEDINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWGIENGVPYWLVANSWNVDWGDNGFFKILRGENHCGIESEIVAGIPRTQQYWGRF
uniprot
proteins
ec_number
3.4.22.1
uniprot
proteins
function
FUNCTION: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:1639824). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). {ECO:0000250|UniProtKB:P07858, ECO:0000250|UniProtKB:P10605, ECO:0000269|PubMed:1639824}.
uniprot
proteins
mass_dalton
37470
uniprot
proteins
protein_family
Peptidase C1 family
uniprot
proteins
pubmed
1639824
uniprot
proteins
pubmed
2986112
uniprot
proteins
pubmed
6574504
uniprot
proteins
pubmed
7890671
uniprot
proteins
pubmed
8001549
uniprot
proteins
pubmed
8740363
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:8001549}. Melanosome {ECO:0000250|UniProtKB:P07858}. Secreted, extracellular space {ECO:0000250|UniProtKB:A1E295}. Apical cell membrane {ECO:0000250|UniProtKB:P10605}; Peripheral membrane protein {ECO:0000250|UniProtKB:P10605}; Extracellular side {ECO:0000250|UniProtKB:P10605}. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells. {ECO:0000250|UniProtKB:P10605}.
uniprot
proteins