MAP3K21
entrez
84451
canonical
uniprot
Q5TCX8
canonical
ensembl
ENSG00000143674
resolver
ensp
ENSP00000355583
resolver
genesymbol
MAP3K21
resolver
genesymbol_syn
KIAA1804
resolver
genesymbol_syn
MLK4
resolver
hgnc
HGNC:29798
resolver
uniprot
A0A1W2PKR9
resolver
uniprot
B2RN34
resolver
uniprot
Q5TCX7
resolver
uniprot
Q5TCX9
resolver
uniprot
Q8WWN1
resolver
uniprot
Q8WWN2
resolver
uniprot
Q96JM1
resolver
uniprot
X6R610
resolver
uniprot_entry
M3K21_HUMAN
resolver
uniprot_sec
A0A1W2PKR9
resolver
uniprot_sec
B2RN34
resolver
uniprot_sec
Q5TCX7
resolver
uniprot_sec
Q5TCX9
resolver
uniprot_sec
Q8WWN1
resolver
uniprot_sec
Q8WWN2
resolver
uniprot_sec
Q96JM1
resolver
uniprot_sec
X6R610
resolver
activity_regulation
ACTIVITY REGULATION: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation. {ECO:0000250|UniProtKB:Q16584}.
uniprot
proteins
amino_acid_sequence
MALRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELNILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSSSSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQMKDRTDCKERIRPLSDGNSPWSTILIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPKQIKLPSQAYIDLPLGKDAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTESALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGIFQRASKSRRSASPPTSLPSTCGEASSPPSLPLSSALGILSTPSFSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCPTAPGSGREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPTPTGATIISATGASALPLCPSPAPHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQAYPQTAVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRSKTSRPSIYELEKEFLS
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. {ECO:0000269|PubMed:21602844}.
uniprot
proteins
mass_dalton
113957
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. {ECO:0000250|UniProtKB:Q16584}.
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21602844
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
1036
uniprot
proteins