Obox5
entrez
252829
canonical
uniprot
G3X9P6
canonical
ensembl
ENSMUSG00000074366
resolver
ensp
ENSMUSP00000096400
resolver
enst
ENSMUST00000098802
resolver
genesymbol
Obox5
resolver
uniprot
G3UZE6
resolver
uniprot
G3UZS7
resolver
uniprot
Q7TPZ5
resolver
uniprot
Q8VHG4
resolver
uniprot_entry
OBOX5_MOUSE
resolver
uniprot_sec
G3UZE6
resolver
uniprot_sec
G3UZS7
resolver
uniprot_sec
Q7TPZ5
resolver
uniprot_sec
Q8VHG4
resolver
amino_acid_sequence
MAEGPSLHPKLQVASNIPIEIRSQIPQEPARNLAFQMSQSPLVTPGSTMQSSLSVPERNLLQQESEGSSRQSGSMPLSDKYVNKQTGPMASRKFRKERTVYTKEQQRLLQKHFDECQYPNEKKIMELAVSVGVTKMEIKIWFKNNRAKYRRMNLQNIKQALPESNGISKAVSESTHFPGSIPVVASDNGESMCSGTFGEDSMPKFNCSQESSLYCFQACDGDMCCPQEYLLDGHAPVTAWNSGQSAAVEYQTDIAVAEAPVRLAYAAQAPEDAHNSGPSADELWQRILEDF
uniprot
proteins
function
FUNCTION: Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:37459895). Together with other Obox family members, required in early two-cell stage embryos to kick-start the major ZGA wave by facilitating RNA Polymerase II 'pre-configuration', during which RNA Polymerase II relocates from the initial one-cell stage binding targets to ZGA gene promoters and distal enhancers (PubMed:37459895). Mechanistically, promotes recruitment of RNA Polymerase II from (CG-rich) non-ZGA genes to (CG-poor) ZGA genes at the two-cell stage (PubMed:37459895). Binds to regulatory DNA sequences containing a 5'-ACNCCTTTAATCCCAG-3' sequence motif (PubMed:37459895). Most maternal and zygotic Obox family proteins can compensate for one another (PubMed:37459895). {ECO:0000269|PubMed:37459895}.
uniprot
proteins
mass_dalton
32302
uniprot
proteins
mutagenesis
MUTAGEN 98; /note="R->E: Abolished DNA-binding."; /evidence="ECO:0000269|PubMed:37459895
uniprot
proteins
protein_family
Obox subfamily
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
11991721
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
37459895
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
uniprot
proteins