Lmnb1
entrez
16906
canonical
uniprot
P14733
canonical
ensembl
ENSMUSG00000024590
resolver
ensp
ENSMUSP00000025486
resolver
enst
ENSMUST00000025486
resolver
genesymbol
Lmnb1
resolver
uniprot
Q61791
resolver
uniprot_entry
LMNB1_MOUSE
resolver
uniprot_sec
Q61791
resolver
amino_acid_sequence
MATATPVQQQRAGSRASAPATPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELADARRALDDTARERAKLQIELGKFKAEHDQLLLNYAKKESDLSGAQIKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLSAAKKQLADETLLKVDLENRCQSLTEDLEFRKNMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELEDMLAKERDNSRRMLSDREREMAEIRDQMQQQLSDYEQLLDVKLALDMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGKRKRVDVEESEASSSVSISHSASATGNVCIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRKIGDTSVSYKYTSRYVLKAGQTVTVWAANAGVTASPPTDLIWKNQNSWGTGEDVKVILKNSQGEEVAQRSTVFKTTIPEEEEEEEEEPIGVAVEEERFHQQGAPRASNKSCAIM
uniprot
proteins
function
FUNCTION: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28241138). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28241138). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28241138). Plays a role in sperm morphological development during late stages of spermiogenesis, particularly the anchoring of the sperm head to the tail (PubMed:38870534). Component of the LMNB1/SUN5/SEPT12 bridge that connects the sperm proximal centriole to the implantation fossa, the bridge functions to prevent detachment of the proximal centriole from the posterior nucleus during steps 13 to 16 of spermiogenesis (PubMed:38870534). {ECO:0000269|PubMed:28241138, ECO:0000269|PubMed:38870534}.
uniprot
proteins
mass_dalton
66786
uniprot
proteins
post_translational_modification
PTM: B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. {ECO:0000250|UniProtKB:P20700}.; PTM: Phosphorylation plays a key role in lamin organization, subcellular localization and nuclear envelope disintegration (By similarity). Phosphorylation by CDK1 at Ser-24 and Ser-394 at the onset of mitosis drives lamin disassembly and nuclear envelope breakdown (By similarity). {ECO:0000250|UniProtKB:P02545}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
28241138
uniprot
proteins
pubmed
3243285
uniprot
proteins
pubmed
38870534
uniprot
proteins
pubmed
39868537
uniprot
proteins
pubmed
8586436
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus lamina {ECO:0000269|PubMed:28241138, ECO:0000269|PubMed:39868537}. Note=Expressed in the posterior part of the nucleus during steps 9 to 12 of spermiogenesis, expression became more localized to the implantation fossa between steps 13 to 16 (PubMed:38870534). Expressed at the neck region in mature sperm (PubMed:38870534). {ECO:0000269|PubMed:38870534}.
uniprot
proteins