Slc35a1
entrez
24060
canonical
uniprot
Q61420
canonical
ensembl
ENSMUSG00000028293
resolver
ensp
ENSMUSP00000029970
resolver
ensp
ENSMUSP00000200364
resolver
enst
ENSMUST00000029970
resolver
genesymbol
Slc35a1
resolver
uniprot
A2AT44
resolver
uniprot_entry
S35A1_MOUSE
resolver
uniprot_sec
A2AT44
resolver
amino_acid_sequence
MAPARENVSLFFKLYCLTVMTLVAAAYTVALRYTRTTAEELYFSTTAVCITEVIKLLISVGLLAKETGSLGRFKASLSENVLGSPKELAKLSVPSLVYAVQNNMAFLALSNLDAAVYQVTYQLKIPCTALCTVLMLNRTLSKLQWISVFMLCGGVTLVQWKPAQATKVVVAQNPLLGFGAIAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGIVVTLAGTYLSDGAEIQEKGFFYGYTYYVWFVIFLASVGGLYTSVVVKYTDNIMKGFSAAAAIVLSTIASVLLFGLQITLSFALGALLVCVSIYLYGLPRQDTTSIQQEATSKERIIGV
uniprot
proteins
function
FUNCTION: Transports CMP-sialic acid from the cytosol into the Golgi apparatus, functioning as an antiporter that exchanges CMP-sialic acid for CMP (PubMed:10085119, PubMed:30985278, PubMed:34015330, PubMed:8755516). Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP (PubMed:30985278). Also able to exchange CMP-sialic acid for AMP and UMP (By similarity). Also mediates the transport of CDP-ribitol (By similarity) (PubMed:34015330). {ECO:0000250|UniProtKB:P78382, ECO:0000269|PubMed:10085119, ECO:0000269|PubMed:30985278, ECO:0000269|PubMed:34015330, ECO:0000269|PubMed:8755516}.
uniprot
proteins
mass_dalton
36453
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="M->S: No effect on CDP-ribitol and CMP-sialic acid transport activity."; /evidence="ECO:0000269|PubMed:34015330"; MUTAGEN 24; /note="A->Y: Loss of CMP-sialic acid transport activity but no effect on CDP-ribitol transport activity."; /evidence="ECO:0000269|PubMed:34015330"; MUTAGEN 27; /note="Y->H: No effect on CDP-ribitol and CMP-sialic acid transport activity."; /evidence="ECO:0000269|PubMed:34015330"; MUTAGEN 105; /note="A->V: No effect on CDP-ribitol and CMP-sialic acid transport activity."; /evidence="ECO:0000269|PubMed:34015330"; MUTAGEN 118; /note="Q->A: No effect on CDP-ribitol and CMP-sialic acid transport activity."; /evidence="ECO:0000269|PubMed:34015330"; MUTAGEN 121; /note="Y->S: No effect on CDP-ribitol and CMP-sialic acid transport activity."; /evidence="ECO:0000269|PubMed:34015330"; MUTAGEN 122; /note="Q->A: No effect on CDP-ribitol and CMP-sialic acid transport activity."; /evidence="ECO:0000269|PubMed:34015330"; MUTAGEN 184; /note="A->Y: Loss of CMP-sialic acid transport activity but no effect on CDP-ribitol transport activity."; /evidence="ECO:0000269|PubMed:34015330"; MUTAGEN 253; /note="A->Q: No effect on CDP-ribitol and CMP-sialic acid transport activity."; /evidence="ECO:0000269|PubMed:34015330"; MUTAGEN 256; /note="G->N: Loss of CMP-sialic acid transport activity but no effect on CDP-ribitol transport activity."; /evidence="ECO:0000269|PubMed:34015330"; MUTAGEN 260; /note="T->M: No effect on CDP-ribitol and CMP-sialic acid transport activity."; /evidence="ECO:0000269|PubMed:34015330"; MUTAGEN 322..336; /note="Missing: No effect on CMP-sialic acid transport activity."; /evidence="ECO:0000269|PubMed:30985278"; MUTAGEN 336; /note="V->VGSKVKGS: Results in localization to the endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:15932921
uniprot
proteins
protein_family
Nucleotide-sugar transporter family
uniprot
proteins
protein_family
SLC35A subfamily
uniprot
proteins
pubmed
10085119
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15932921
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30985278
uniprot
proteins
pubmed
34015330
uniprot
proteins
pubmed
8755516
uniprot
proteins
sequence_length
336
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:10085119, ECO:0000269|PubMed:15932921, ECO:0000269|PubMed:8755516}; Multi-pass membrane protein {ECO:0000269|PubMed:10085119}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000269|PubMed:30985278"; TRANSMEM 46..64; /note="Helical"; /evidence="ECO:0000269|PubMed:30985278"; TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000269|PubMed:30985278"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000269|PubMed:30985278"; TRANSMEM 142..160; /note="Helical"; /evidence="ECO:0000269|PubMed:30985278"; TRANSMEM 176..196; /note="Helical"; /evidence="ECO:0000269|PubMed:30985278"; TRANSMEM 210..228; /note="Helical"; /evidence="ECO:0000269|PubMed:30985278"; TRANSMEM 244..262; /note="Helical"; /evidence="ECO:0000269|PubMed:30985278"; TRANSMEM 270..288; /note="Helical"; /evidence="ECO:0000269|PubMed:30985278"; TRANSMEM 297..315; /note="Helical"; /evidence="ECO:0000269|PubMed:30985278
uniprot
proteins