Tsc22d4
entrez
78829
canonical
uniprot
Q9EQN3
canonical
ensembl
ENSMUSG00000144223
resolver
ensp
ENSMUSP00000098107
resolver
enst
ENSMUST00000100539
resolver
genesymbol
Tsc22d4
resolver
genesymbol_syn
Thg1-pit
resolver
uniprot
Q99PD5
resolver
uniprot
Q9D2V9
resolver
uniprot_entry
T22D4_MOUSE
resolver
uniprot_sec
Q99PD5
resolver
uniprot_sec
Q9D2V9
resolver
amino_acid_sequence
MSGGKKKSSFQITSVTTDYEGPGSPGASDSPVPPALAGPPPRLPNGDPNPDPGGRGTPRNGSPPPGAPASRFRVVKLPQGLGEPYRRGRWTCVDVYERDLEPPSFGRLLEGIRGASGGTGGRSLDSRLELASLGISTPIPQPGLSQGPTSWLRPPPTSPGPQARSFTGGLGQLAGPGKAKVETPPLSASPPQQRPPGPGTGDSAQTLPSLRVEVESGGSAAATPPLSRRRDGAVRLRMELVAPAETGKVPPTDSRPNSPALYFDASLVHKSPDPFGAAAAQSLSLARSMLAISGHLDSDDDSGSGSLVGIDNKIEQAMDLVKSHLMFAVREEVEVLKEQIRDLAERNAALEQENGLLRALASPEQLAQLPSSGLPRLGPSAPNGPSI
uniprot
proteins
function
FUNCTION: Binds DNA and acts as a transcriptional repressor (PubMed:27827363). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (PubMed:27827363). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (PubMed:20878296). {ECO:0000269|PubMed:20878296, ECO:0000269|PubMed:23307490, ECO:0000269|PubMed:27827363}.
uniprot
proteins
mass_dalton
39979
uniprot
proteins
protein_family
TSC-22/Dip/Bun family
uniprot
proteins
pubmed
11707329
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17147695
uniprot
proteins
pubmed
20878296
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23307490
uniprot
proteins
pubmed
27827363
uniprot
proteins
sequence_length
387
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20878296}. Cytoplasm {ECO:0000269|PubMed:20878296}. Cell projection, dendrite {ECO:0000269|PubMed:20878296}. Synapse {ECO:0000269|PubMed:20878296}. Note=Localizes away from the nucleus to neurite processes and synaptic termini as cerebellar granular neurons differentiate (PubMed:20878296). Accumulates in the cytoplasm of differentiated Purkinje cells (PubMed:20878296). Localized to both the cytoplasm and nucleus in immature cerebellar granular neurons and atrophic Purkinje cells (PubMed:20878296). {ECO:0000269|PubMed:20878296}.
uniprot
proteins