PIEZO2
entrez
63895
canonical
uniprot
Q9H5I5
canonical
ensembl
ENSG00000154864
resolver
ensp
ENSP00000372900
resolver
ensp
ENSP00000421377
resolver
ensp
ENSP00000463094
resolver
ensp
ENSP00000501957
resolver
enst
ENST00000674853
resolver
genesymbol
PIEZO2
resolver
genesymbol_syn
C18orf30
resolver
genesymbol_syn
C18orf58
resolver
genesymbol_syn
FAM38B
resolver
hgnc
HGNC:26270
resolver
uniprot
A0A2H4UKA7
resolver
uniprot
A0A6Q8PFS6
resolver
uniprot
B7Z812
resolver
uniprot
M4GPJ9
resolver
uniprot
Q6ZS91
resolver
uniprot
Q8N787
resolver
uniprot
Q8NAR6
resolver
uniprot
Q9H5R4
resolver
uniprot_entry
A0A2H4UKA7_HUMAN
resolver
uniprot_entry
A0A6Q8PFS6_HUMAN
resolver
uniprot_entry
PIEZ2_HUMAN
resolver
uniprot_sec
B7Z812
resolver
uniprot_sec
M4GPJ9
resolver
uniprot_sec
Q6ZS91
resolver
uniprot_sec
Q8N787
resolver
uniprot_sec
Q8NAR6
resolver
uniprot_sec
Q9H5R4
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by auxillary subunits MDFIC and MDFI (PubMed:37590348). Channel activity is inhibited by TMEM120A (By similarity). Phosphatidic acid and lysophosphatidic acid inhibit PIEZO2 channel activity (By similarity). {ECO:0000250|UniProtKB:Q8CD54, ECO:0000269|PubMed:37590348}.
uniprot
proteins
amino_acid_sequence
MASEVVCGLIFRLLLPICLAVACAFRYNGLSFVYLIYLLLIPLFSEPTKTTMQGHTGRLLKSLCFISLSFLLLHIIFHITLVSLEAQHRIAPGYNCSTWEKTFRQIGFESLKGADAGNGIRVFVPDIGMFIASLTIWLLCRNIVQKPVTDEAAQSNPEFENEELAEGEKIDSEEALIYEEDFNGGDGVEGELEESTKLKMFRRLASVASKLKEFIGNMITTAGKVVVTILLGSSGMMLPSLTSSVYFFVFLGLCTWWSWCRTFDPLLFSCLCVLLAIFTAGHLIGLYLYQFQFFQEAVPPNDYYARLFGIKSVIQTDCSSTWKIIVNPDLSWYHHANPILLLVMYYTLATLIRIWLQEPLVQDEGTKEEDKALACSPIQITAGRRRSLWYATHYPTDERKLLSMTQDDYKPSDGLLVTVNGNPVDYHTIHPSLPMENGPGKADLYSTPQYRWEPSDESSEKREEEEEEKEEFEEERSREEKRSIKVHAMVSVFQFIMKQSYICALIAMMAWSITYHSWLTFVLLIWSCTLWMIRNRRKYAMISSPFMVVYGNLLLILQYIWSFELPEIKKVPGFLEKKEPGELASKILFTITFWLLLRQHLTEQKALQEKEALLSEVKIGSQENEEKDEELQDIQVEGEPKEEEEEEAKEEKQERKKVEQEEAEEEDEQDIMKVLGNLVVAMFIKYWIYVCGGMFFFVSFEGKIVMYKIIYMVLFLFCVALYQVHYEWWRKILKYFWMSVVIYTMLVLIFIYTYQFENFPGLWQNMTGLKKEKLEDLGLKQFTVAELFTRIFIPTSFLLVCILHLHYFHDRFLELTDLKSIPSKEDNTIYRLAHPEGSLPDLTMMHLTASLEKPEVRKLAEPGEEKLEGYSEKAQKGDLGKDSEESEEDGEEEEESEEEEETSDLRNKWHLVIDRLTVLFLKFLEYFHKLQVFMWWILELHIIKIVSSYIIWVSVKEVSLFNYVFLISWAFALPYAKLRRLASSVCTVWTCVIIVCKMLYQLQTIKPENFSVNCSLPNENQTNIPFNELNKSLLYSAPIDPTEWVGLRKSSPLLVYLRNNLLMLAILAFEVTIYRHQEYYRGRNNLTAPVSRTIFHDITRLHLDDGLINCAKYFINYFFYKFGLETCFLMSVNVIGQRMDFYAMIHACWLIAVLYRRRRKAIAEIWPKYCCFLACIITFQYFICIGIPPAPCRDYPWRFKGASFNDNIIKWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCRSYLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGTLVHNSCWLIQAFSLACTVKGYQMPAANSPCTLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQEPGEGQDMQKLSEEDDEREADKQKAKGKKKQWWRPWVDHASMVRSGDYYLFETDSEEEEEEELKKEDEEPPRRSAFQFVYQAWITDPKTALRQRHKEKKRSAREERKRRRKGSKEGPVEWEDREDEPIKKKSDGPDNIIKRIFNILKFTWVLFLATVDSFTTWLNSISREHIDISTVLRIERCMLTREIKKGNVPTRESIHMYYQNHIMNLSRESGLDTIDEHPGAASGAQTAHRMDSLDSHDSISSEPTQCTMLYSRQGTTETIEEVEAEQEEEAGSTAPEPREAKEYEATGYDVGAMGAEEASLTPEEELTQFSTLDGDVEAPPSYSKAVSFEHLSFGSQDDSAGKNRMAVSPDDSRTDKLGSSILPPLTHELTASELLLKKMFHDDELEESEKFYVGQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMVSASMITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKNVEVNKDKPYHPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDEDDMTESGMAREESDDELSLGHGRRDSSDSLKSINLAASVESVHVTFPEQQTAVRRKRSGSSSEPSQRSSFSSNRSQRGSTSTRNSSQKGSSVLSIKQKGKRELYMEKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKYNSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREKTN
uniprot
proteins
disease_involvement
DISEASE: Arthrogryposis, distal, 5 (DA5) [MIM:108145]: A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA5 features include ocular abnormalities, typically ptosis, ophthalmoplegia and/or strabismus, in addition to contractures of the skeletal muscles. Some patients have pulmonary hypertension as a result of restrictive lung disease. {ECO:0000269|PubMed:23487782, ECO:0000269|PubMed:24726473}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Arthrogryposis, distal, 3 (DA3) [MIM:114300]: A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA3 features include short stature and cleft palate. {ECO:0000269|PubMed:24726473}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Marden-Walker syndrome (MWKS) [MIM:248700]: A syndrome characterized by a mask-like face with blepharophimosis, micrognathia, cleft or high-arched palate, low-set ears, congenital joint contractures, kyphoscoliosis, pectus excavatum or carinatum, and arachnodactyly. Additional features include decreased muscular mass, failure to thrive, renal anomalies, hypoplastic corpus callosum, cerebellar vermis hypoplasia, enlarged cisterna magna, and psychomotor retardation. {ECO:0000269|PubMed:24726473}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Arthrogryposis, distal, with impaired proprioception and touch (DAIPT) [MIM:617146]: A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DAIPT is an autosomal recessive disease characterized by selective loss of discriminative touch perception, ataxia, difficulty walking, dysmetria, and progressive skeletal contractures. {ECO:0000269|PubMed:27607563, ECO:0000269|PubMed:27653382}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (By similarity). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (By similarity). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (By similarity). In the lower urinary tract, acts as a sensor in both the bladder urothelium and innervating sensory neurons being required for bladder-stretch sensing and urethral micturition reflexes, ensuring proper urinary function (PubMed:33057202). Additionally, PIEZO2 serves as the principal mechanotransducer in proprioceptors, facilitating proprioception and coordinated body movements (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). Required for Merkel-cell mechanotransduction (By similarity). Plays a major role in light-touch mechanosensation (By similarity). In kidney, during blood volume challenges, regulates calcium dynamics and maintains renin production, thereby serving as an essential regulator of the renin-angiotensin-aldosterone system (RAAS) and systemic blood volume control (By similarity). {ECO:0000250|UniProtKB:Q8CD54, ECO:0000269|PubMed:33057202, ECO:0000269|PubMed:37590348}.
uniprot
proteins
mass_dalton
318064
uniprot
proteins
protein_family
PIEZO (TC 1.A.75) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
23487782
uniprot
proteins
pubmed
24726473
uniprot
proteins
pubmed
27607563
uniprot
proteins
pubmed
27653382
uniprot
proteins
pubmed
33057202
uniprot
proteins
pubmed
37590348
uniprot
proteins
sequence_length
2752
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8CD54}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8CD54}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..24; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 31..43; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 51..76; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 123..141; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 222..237; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 241..258; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 265..287; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 336..355; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 493..514; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 520..531; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 536..562; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 584..614; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 686..699; /note="Helical; Name=13"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 706..724; /note="Helical; Name=14"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 734..753; /note="Helical; Name=15"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 786..807; /note="Helical; Name=16"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 941..956; /note="Helical; Name=17"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 963..972; /note="Helical; Name=18"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 981..1001; /note="Helical; Name=19"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 1058..1082; /note="Helical; Name=20"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 1124..1138; /note="Helical; Name=21"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 1141..1154; /note="Helical; Name=22"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 1166..1185; /note="Helical; Name=23"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 1223..1243; /note="Helical; Name=24"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 1298..1310; /note="Helical; Name=25"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 1317..1329; /note="Helical; Name=26"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 1339..1364; /note="Helical; Name=27"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 1414..1430; /note="Helical; Name=28"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 1922..1936; /note="Helical; Name=29"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 1944..1955; /note="Helical; Name=30"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 1962..1983; /note="Helical; Name=31"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 2017..2035; /note="Helical; Name=32"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 2190..2209; /note="Helical; Name=33"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 2232..2252; /note="Helical; Name=34"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 2257..2280; /note="Helical; Name=35"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 2290..2312; /note="Helical; Name=36"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 2398..2421; /note="Helical; Name=37"; /evidence="ECO:0000250|UniProtKB:Q8CD54"; TRANSMEM 2670..2690; /note="Helical; Name=38"; /evidence="ECO:0000250|UniProtKB:Q8CD54
uniprot
proteins