Ppp2ca
entrez
24672
canonical
uniprot
P63331
canonical
ensembl
ENSRNOG00055005151
resolver
ensembl
ENSRNOG00060025630
resolver
ensembl
ENSRNOG00065005401
resolver
ensp
ENSRNOP00055006227
resolver
ensp
ENSRNOP00060036781
resolver
ensp
ENSRNOP00065005585
resolver
enst
ENSRNOT00055008257
resolver
enst
ENSRNOT00060044379
resolver
enst
ENSRNOT00065007998
resolver
genesymbol
Ppp2ca
resolver
uniprot
O88591
resolver
uniprot
P13353
resolver
uniprot_entry
PP2AA_RAT
resolver
uniprot_sec
O88591
resolver
uniprot_sec
P13353
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the interaction between PPP2R2A and ARPP19; this inhibition is enhanced when ARPP19 is phosphorylated (By similarity). Inhibited by the interaction between PPP2R2A and PABIR1/FAM122A (By similarity). {ECO:0000250|UniProtKB:P67775}.
uniprot
proteins
amino_acid_sequence
MDEKLFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (By similarity). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate various proteins, such as AXIN1, p53/TP53, PIM3, WEE1. Activates RAF1 by dephosphorylating it at 'Ser-259'. Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC. Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (By similarity). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome. Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway. Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Catalyzes dephosphorylation of PIM3, promoting PIM3 ubiquitination and proteasomal degradation. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex. The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (By similarity). {ECO:0000250|UniProtKB:P63330, ECO:0000250|UniProtKB:P67775}.
uniprot
proteins
mass_dalton
35608
uniprot
proteins
post_translational_modification
PTM: Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (Lcmt1) and protein phosphatase methylesterase 1 (Ppme1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization (By similarity). {ECO:0000250|UniProtKB:P67774}.; PTM: Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation (By similarity). {ECO:0000250|UniProtKB:P67774}.; PTM: Polyubiquitinated, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:P67775}.; PTM: Ubiquitinated by the SCF(FBXO42) complex; leading to proteasomal degradation. {ECO:0000250|UniProtKB:P67775}.
uniprot
proteins
protein_family
PP-1 subfamily
uniprot
proteins
protein_family
PPP phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2461222
uniprot
proteins
pubmed
2554255
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P67775}. Nucleus {ECO:0000250|UniProtKB:P67775}. Chromosome {ECO:0000250|UniProtKB:P67775}. Chromosome, centromere {ECO:0000250|UniProtKB:P67775}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P67775}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles (By similarity). Centromeric localization requires the presence of SGO2 (By similarity). Recruited to chromatin and transcription pause-release checkpoint via its association with the Integrator complex (By similarity). {ECO:0000250|UniProtKB:P63330, ECO:0000250|UniProtKB:P67775}.
uniprot
proteins