Oprd1
entrez
18386
canonical
uniprot
P32300
canonical
ensembl
ENSMUSG00000050511
resolver
ensp
ENSMUSP00000050077
resolver
enst
ENSMUST00000056336
resolver
genesymbol
Oprd1
resolver
uniprot
A2AD37
resolver
uniprot
Q8BLP9
resolver
uniprot_entry
A2AD37_MOUSE
resolver
uniprot_entry
OPRD_MOUSE
resolver
uniprot_entry
Q8BLP9_MOUSE
resolver
amino_acid_sequence
MELVPSARAELQSSPLVNLSDAFPSAFPSAGANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRTPCGRQEPGSLRRPRQATTRERVTACTPSDGPGGGAAA
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. {ECO:0000269|PubMed:10677041, ECO:0000269|PubMed:1334555, ECO:0000269|PubMed:1335167}.
uniprot
proteins
mass_dalton
40561
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. A basal ubiquitination does not seem to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4. {ECO:0000269|PubMed:18836069}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10677041
uniprot
proteins
pubmed
1334555
uniprot
proteins
pubmed
1335167
uniprot
proteins
pubmed
18836069
uniprot
proteins
pubmed
22596164
uniprot
proteins
pubmed
8393575
uniprot
proteins
pubmed
8397421
uniprot
proteins
pubmed
8415697
uniprot
proteins
pubmed
8844829
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10677041, ECO:0000269|PubMed:1334555, ECO:0000269|PubMed:1335167, ECO:0000269|PubMed:18836069, ECO:0000269|PubMed:22596164}; Multi-pass membrane protein {ECO:0000269|PubMed:10677041, ECO:0000269|PubMed:1334555, ECO:0000269|PubMed:1335167, ECO:0000269|PubMed:22596164}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..75; /note="Helical; Name=1"; TRANSMEM 86..110; /note="Helical; Name=2"; TRANSMEM 123..144; /note="Helical; Name=3"; TRANSMEM 164..186; /note="Helical; Name=4"; TRANSMEM 207..238; /note="Helical; Name=5"; TRANSMEM 262..284; /note="Helical; Name=6"; TRANSMEM 300..321; /note="Helical; Name=7
uniprot
proteins