Asxl3
entrez
211961
canonical
uniprot
Q8C4A5
canonical
ensembl
ENSMUSG00000045215
resolver
ensp
ENSMUSP00000112793
resolver
ensp
ENSMUSP00000159205
resolver
genesymbol
Asxl3
resolver
uniprot
Q8C380
resolver
uniprot_entry
ASXL3_MOUSE
resolver
uniprot_sec
Q8C380
resolver
amino_acid_sequence
MKDKRKKKDRTWAEAARLALEKHPNSPMTAKQILEVIQKEGLKETGTSPLACLNAMLHTNTRVGDGTFFKIPGKSGLYALRKEESSCPVDGTLDLVVDPDLDGAEMAEASANGEENRVCTKQVTDEVSSTRDCSLTNTAVQSKLVSSFQQHTKKALKQALRQQQKRRNGVSMMVNKTVPRVVLTPLKVSDEQSDSPSGSESKNGEADSSDKEMKHGQKSPTGKQTSQHLKRLKKSGLGHLKWTKAEDIDIETPGSILVNTNLRALINKHTFASFPQHFQQYLLLLLPEVDRQMGSDGILRLSTSALNNEFFAYAAQGWKQRLAEGEFTPEMQLRIRQEIEKEKKTEPWKEKFFERFYGERSGMSREESIKLTSGPNHEGAEGSSSHGDSGIPGPSAQNALEEQQPKILKSSASLEPDFCTTVCPMLEVPVKDVMTESETEDIFIPEESVIQEEVAEEVETSIYECQDEHLKTIPAFSEESESPATPCEEPQVAAPEDSLESCVVMNDILHTLPHIEVKIVEKLECPQEEMSVVIDQLEICDSLLPCPSSVTHILDVEQKEQETTIETSAMALREGPSSLESQLPNEGIAVDMELQSDPEEQLSENACISETSFSSESPEGACASLPSPGGETQSTSEESCTPASLETTFCSEVSSTENTDKYNQRNPTGESLHASLVSEVSPLATSPEISEASLMSNLPLTSEASPVSNLPLTSEASPMSDLPPTSETSSESSMPLTSETPFVSSLPIPAETSPISNSSVNERMVHQQRKSPSGSEEANSPQKEEPSIPTKPLGESLVSHPKPLSTIPEPINMSSAMVPEALPPEGLHSQTLSQEPCNAHVEMEKLYASSIPELPSSEMTKVKNHSVLQRPEKKGLSAPLEVPVFSEETETKGIELPPAKLQDKQYAPSVDKATFLEGSRNKIHKQSSTLNRLETSHTSKVSEPSKSPDGIRNDNRESEISKRKTVEHSFGICKEKRARIEDDQSARSLASSSPPEKEQPPREEPRVPPLKIQLSKIGPPFIIKSQPVSKAESRASTSTSVSSGRNTGARTLADIKARAQQARAQREAAAAAAVAAAASIVSGAMGSPGEGGKARTLAHIKEQTKAKLFAKHQSRAHLFQTSKETRLPSVSTKEDSLNMEASPTPETKMEGSTGVIIINPNCRSPSSKPTHIREITTVLQQPLNPPQIPETATDLSVHSSDDNIPVSHLTEKIVSSTSSENSSVPILHNKSPINPIPMSVCSTAMSGAIKEHPFVSPVDKSSVLMSVDSANSTISACNISMLKSIQGSDAPCIALVPKCINRTPIPAAPEGTGQSNSMDGKALLVPSSKAANVISNQYTSVPAPTIASNLPNHLCTSSVLIPPTGINNRFVSEKIAMPGSEEQAAVSIGATMRTALSCGDSVAVTDSLVPRSPIAMFAGNMLTANSYNCPPKLSGENLDNNSGPLNRTDNSEKPQQPAGGFVPATINRSIPCKVIVDHSTTLTSNLSLTVSIESGDSSLDSQTRSVRTDVSIQPVACPQVSVISRPEQATSEGLDHGSVFIAAPTAKQDCKTLQATCTSLRELPLTLPDKLNEVTVPTHGFAEQARNSSTFKKETDTACSNQYNPGNRICWSEDPMRNTAPPVVSHSSSSKQKEHPEQTGLKAVKTEHVSYAHVSDLHPRNLITNVSLPVKPEPHEVDKGFRMDTEDFPGPERPPPVTEVTSSASVQPTQTMKPSTTSPVEEAISLAPDTLKRIPSASSSSCRLSSVEANNPLVTQLLQGNLPLEKVLPQPRLGAKLEINRLPLPLQTTSVGKTGLERNMVEMPSSSPNPDGKGYLAGTLAPVQMRKRENHPKKRAARTVGDHAQVKCEPGKMVMEPDVKAVPCVISPSMSQLGHNQPFKQERLNKPSMANRIMPSPEVKQQKRLLPACSFQPSLFHVNKNEGFHADTGTSHRQQFYQMPMAARGPLPTPALLQNSPKTPVGCNAFAFNRHLEQKALGDVNLPTAPHQLRLANMLSPNMPIKEGEDGGGTTHTMPSKAVVHAPLPPPPPPPPPPPPPLALPPPPPPPPPLPPPLPTVEVPSDQKQPPVNMETTKRLSWPQSTGICSNIKSEPLSFEESLSSSCELGMKQVPYDQNEVKEQLKAFALKNADFSSYLLSEPQKPFTQLAAQKLPVPQQQPLCGSYPTIHFGSTNFKRAASAIEKSIGILGSGSNPATSTGLTGQNTQMPVQNFADNSNADELELKCSCRLKAMIVCKGCGAFCHDDCIGPSKLCVACLVVR
uniprot
proteins
function
FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (By similarity). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex and are essential for chromatin recruitment and transcriptional activation of associated genes (PubMed:32747411). {ECO:0000250, ECO:0000250|UniProtKB:Q9C0F0, ECO:0000269|PubMed:32747411}.
uniprot
proteins
mass_dalton
243673
uniprot
proteins
protein_family
Asx family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16412590
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
32747411
uniprot
proteins
sequence_length
2259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins