Asic1
entrez
11419
canonical
uniprot
Q6NXK8
canonical
ensembl
ENSMUSG00000023017
resolver
ensp
ENSMUSP00000023758
resolver
ensp
ENSMUSP00000154379
resolver
ensp
ENSMUSP00000260653
resolver
ensp
ENSMUSP00000260655
resolver
ensp
ENSMUSP00000260657
resolver
genesymbol
Asic1
resolver
genesymbol_syn
Accn2
resolver
genesymbol_syn
Asic
resolver
genesymbol_syn
Bnac2
resolver
uniprot
Q50K97
resolver
uniprot_entry
ASIC1_MOUSE
resolver
uniprot_sec
Q50K97
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the diuretic drug amiloride. {ECO:0000269|PubMed:15369669}.; ACTIVITY REGULATION: [Isoform Asic1b]: The activity of the channel is sensitive to rapid decrease in osmotic pressure. {ECO:0000269|PubMed:18158916}.
uniprot
proteins
amino_acid_sequence
MELKTEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFCYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEACSAEDFKVVFTRYGKCYTFNSGQDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLIYLPSPWGTCNAVTMDSDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHRLCRRGKCQKEAKRNSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
uniprot
proteins
function
FUNCTION: Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:11988176, PubMed:12843249, PubMed:15369669, PubMed:17060608). Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:15369669). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:15369669). Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines (PubMed:15369669, PubMed:17060608). Modulates neuronal activity in the circuits underlying innate fear (PubMed:17662962). {ECO:0000269|PubMed:11988176, ECO:0000269|PubMed:12843249, ECO:0000269|PubMed:15369669, ECO:0000269|PubMed:17060608, ECO:0000269|PubMed:17662962}.; FUNCTION: [Isoform Asic1b]: Has high selectivity for sodium ions but is also potentially permeable to other cations including potassium (PubMed:18158916, PubMed:21036899). Could function in cochlear mechanoelectrical transduction (PubMed:18158916). {ECO:0000269|PubMed:18158916, ECO:0000269|PubMed:21036899}.
uniprot
proteins
mass_dalton
59668
uniprot
proteins
post_translational_modification
PTM: pH-gating could be regulated by serine proteases. {ECO:0000250|UniProtKB:P78348}.; PTM: Phosphorylation by PKA regulates interaction with PICK1 and subcellular localization. Phosphorylation by PKC may regulate the channel. {ECO:0000250|UniProtKB:P78348}.
uniprot
proteins
protein_family
ASIC1 subfamily
uniprot
proteins
protein_family
Amiloride-sensitive sodium channel (TC 1.A.6) family
uniprot
proteins
pubmed
11988176
uniprot
proteins
pubmed
12843249
uniprot
proteins
pubmed
15369669
uniprot
proteins
pubmed
15471860
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15578512
uniprot
proteins
pubmed
17060608
uniprot
proteins
pubmed
17662962
uniprot
proteins
pubmed
18158916
uniprot
proteins
pubmed
21036899
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
526
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11988176}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P78348}. Postsynaptic cell membrane {ECO:0000305|PubMed:11988176}. Cell projection, dendrite {ECO:0000269|PubMed:15471860, ECO:0000269|PubMed:17060608}. Note=Isolated in synaptosomes from the dendritic synapses of neurons. {ECO:0000269|PubMed:11988176}.; SUBCELLULAR LOCATION: [Isoform Asic1a]: Cell membrane {ECO:0000250|UniProtKB:P55926}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 50..66; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P78348"; TRANSMEM 426..456; /note="Discontinuously helical"; /evidence="ECO:0000250|UniProtKB:P78348
uniprot
proteins