IL34
entrez
146433
canonical
uniprot
Q6ZMJ4
canonical
ensembl
ENSG00000157368
resolver
ensp
ENSP00000288098
resolver
ensp
ENSP00000397863
resolver
ensp
ENSP00000463886
resolver
ensp
ENSP00000547165
resolver
ensp
ENSP00000547169
resolver
ensp
ENSP00000623454
resolver
enst
ENST00000566361
resolver
genesymbol
IL34
resolver
genesymbol_syn
C16orf77
resolver
hgnc
HGNC:28529
resolver
uniprot
B2RC28
resolver
uniprot
B2Z4A8
resolver
uniprot
B2ZC70
resolver
uniprot
J3QQT3
resolver
uniprot
Q8N6L2
resolver
uniprot_entry
IL34_HUMAN
resolver
uniprot_entry
J3QQT3_HUMAN
resolver
uniprot_sec
B2RC28
resolver
uniprot_sec
B2Z4A8
resolver
uniprot_sec
B2ZC70
resolver
uniprot_sec
Q8N6L2
resolver
amino_acid_sequence
MPRGFTWLRYLGIFLGVALGNEPLEMWPLTQNEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCEVPSPQSCSPEPSLQYAATQLYPPPPWSPSSPPHSTGSVRPVRAQGEGLLP
uniprot
proteins
function
FUNCTION: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. {ECO:0000269|PubMed:18467591, ECO:0000269|PubMed:20489731, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}.
uniprot
proteins
mass_dalton
27482
uniprot
proteins
protein_family
IL-34 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
18467591
uniprot
proteins
pubmed
20489731
uniprot
proteins
pubmed
20504948
uniprot
proteins
pubmed
20829061
uniprot
proteins
sequence_length
242
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18467591}.
uniprot
proteins