Tmem33
entrez
67878
canonical
uniprot
Q9CR67
canonical
ensembl
ENSMUSG00000037720
resolver
ensp
ENSMUSP00000042852
resolver
ensp
ENSMUSP00000124390
resolver
ensp
ENSMUSP00000124765
resolver
ensp
ENSMUSP00000124766
resolver
enst
ENSMUST00000037918
resolver
enst
ENSMUST00000160352
resolver
enst
ENSMUST00000161369
resolver
enst
ENSMUST00000162543
resolver
genesymbol
Tmem33
resolver
genesymbol_syn
Db83
resolver
uniprot
A0A0R4J1Z3
resolver
uniprot
F6UHC5
resolver
uniprot
Q544Q3
resolver
uniprot
Q9CZM3
resolver
uniprot
Q9D3M3
resolver
uniprot
Q9DAV4
resolver
uniprot_entry
A0A0R4J1Z3_MOUSE
resolver
uniprot_entry
F6UHC5_MOUSE
resolver
uniprot_entry
Q9CZM3_MOUSE
resolver
uniprot_entry
TMM33_MOUSE
resolver
uniprot_sec
Q544Q3
resolver
uniprot_sec
Q9D3M3
resolver
uniprot_sec
Q9DAV4
resolver
amino_acid_sequence
MADTTPNGPQGAGAVQFMMTNKLDTAMWLSRLFTVYCSALFVLPLLGLHEAASFYQRALLANALTSALRLHQRLPHFQLSRAFLAQALLEDSCHYLLYSLIFVNSYPVTMSIFPVLLFSLLHAATYTKKVLDAKGSNSLPLLRSFLDKLSTNQQNILKFIACNEIFLMPATVFMLFSGQGSLLQPFIYYRFLTLRYSSRRNPYCRNLFNELRIVVEHIIMKPSCPLFVRRLCLQSIAFISRLAPTVA
uniprot
proteins
function
FUNCTION: Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (PubMed:31048699). Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling. Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis. Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (By similarity). {ECO:0000250|UniProtKB:P57088, ECO:0000269|PubMed:31048699}.
uniprot
proteins
mass_dalton
28031
uniprot
proteins
protein_family
PER33/POM33 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31048699
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:31048699}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000250|UniProtKB:P57088}. Nucleus envelope {ECO:0000250|UniProtKB:P57088}. Note=Co-localizes with RTN4 at the ER sheets. {ECO:0000250|UniProtKB:P57088}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 101..121; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 156..176; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins