Sytl4
entrez
27359
canonical
uniprot
Q9R0Q1
canonical
ensembl
ENSMUSG00000031255
resolver
ensp
ENSMUSP00000033608
resolver
ensp
ENSMUSP00000108919
resolver
ensp
ENSMUSP00000108922
resolver
genesymbol
Sytl4
resolver
genesymbol_syn
Slp4
resolver
genesymbol_syn
slp4-a
resolver
uniprot
B1AVI8
resolver
uniprot
B1AVI9
resolver
uniprot
Q549X6
resolver
uniprot
Q8R321
resolver
uniprot
Q9R0Q0
resolver
uniprot_entry
Q549X6_MOUSE
resolver
uniprot_entry
SYTL4_MOUSE
resolver
uniprot_sec
B1AVI8
resolver
uniprot_sec
B1AVI9
resolver
uniprot_sec
Q8R321
resolver
uniprot_sec
Q9R0Q0
resolver
amino_acid_sequence
MSEILDLSFLSEMERDLILGVLQRDEELRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQEGLGRLIPKSSTCVGCNHLVCRECRVLESNGSWRCKVCSKEIELKKATGDWFYDQKVNRFDYRTGSEIIRMSLRQKPAVNKRETAGQSLLQQTQMGDIWPGRRIIQEQQQREQSVLFEVPKTRSGKSALEAESESLDSYTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKEIPPGNQNAVCGDEGDMVFKKNTKKVLRPSEYTKSVIDLRPEDVAQESGILGDRSKSVPGLSVDMEEEEEEEEDIDHLVKLHRQKLARGSMQSGSSMSTLGSIMSIYSEAGDFGNISVTGKIAFSLKFEQKTQTLVIHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETFRYEISESLLAQRTLQFSVWHHGRFGRNTFLGEAEVHMDSWKLDKKLDHCLPLHGKISTESSPGLPAHKGELVVSLKYIPASKLPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKSGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLSPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLRSSMVKQKLGV
uniprot
proteins
function
FUNCTION: Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner. {ECO:0000269|PubMed:12590134}.
uniprot
proteins
mass_dalton
76021
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="E->A: Abolishes interaction with RAB27A."; /evidence="ECO:0000269|PubMed:12590134"; MUTAGEN 18; /note="I->A: Abolishes interaction with RAB27A."; /evidence="ECO:0000269|PubMed:12590134"; MUTAGEN 21; /note="V->A: Abolishes interaction with RAB27A."; /evidence="ECO:0000269|PubMed:12590134"; MUTAGEN 32; /note="D->A: Abolishes interaction with RAB27A."; /evidence="ECO:0000269|PubMed:12590134"; MUTAGEN 43; /note="L->A: Strongly reduces interaction with STX1A."; /evidence="ECO:0000269|PubMed:12101244"; MUTAGEN 118; /note="W->S: Strongly reduces interaction with RAB27A."; /evidence="ECO:0000269|PubMed:12101244
uniprot
proteins
pubmed
10497219
uniprot
proteins
pubmed
11773082
uniprot
proteins
pubmed
11956164
uniprot
proteins
pubmed
12101244
uniprot
proteins
pubmed
12590134
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23798443
uniprot
proteins
sequence_length
673
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10497219}; Peripheral membrane protein {ECO:0000269|PubMed:10497219}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:10497219}; Peripheral membrane protein {ECO:0000269|PubMed:10497219}. Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles.
uniprot
proteins