SAYSD1
entrez
55776
canonical
uniprot
Q9NPB0
canonical
ensembl
ENSG00000112167
resolver
ensp
ENSP00000229903
resolver
genesymbol
SAYSD1
resolver
genesymbol_syn
C6orf64
resolver
hgnc
HGNC:21025
resolver
uniprot
Q9H0D8
resolver
uniprot_entry
SAYS1_HUMAN
resolver
uniprot_sec
Q9H0D8
resolver
amino_acid_sequence
MEQRLAEFRAARKRAGLAAQPPAASQGAQTPGEKAEAAATLKAAPGWLKRFLVWKPRPASARAQPGLVQEAAQPQGSTSETPWNTAIPLPSCWDQSFLTNITFLKVLLWLVLLGLFVELEFGLAYFVLSLFYWMYVGTRGPEEKKEGEKSAYSVFNPGCEAIQGTLTAEQLERELQLRPLAGR
uniprot
proteins
function
FUNCTION: Ufmylation 'reader' component of a translocation-associated quality control pathway, a mechanism that takes place when a ribosome has stalled during translation, and which is required to degrade clogged substrates (PubMed:36848233). Specifically recognizes and binds ufmylated ribosomes when a ribosome has stalled, promoting the transport of stalled nascent chain via the TRAPP complex to lysosomes for degradation (PubMed:36848233). {ECO:0000269|PubMed:36848233}.
uniprot
proteins
mass_dalton
20163
uniprot
proteins
mutagenesis
MUTAGEN 5..12; /note="LAEFRAAR->AAARAAA: In 3A mutant; abolished interaction with ribosomes."; /evidence="ECO:0000269|PubMed:36848233"; MUTAGEN 7..14; /note="EFRAARKR->AAAAAAAA: Abolished interaction with ribosomes."; /evidence="ECO:0000269|PubMed:36848233"; MUTAGEN 150..156; /note="SAYSVFN->AAAAAAA: In 7A mutant; abolished involvement in the translocation-associated quality control pathway."; /evidence="ECO:0000269|PubMed:36848233
uniprot
proteins
protein_family
SAYSD1 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22361696
uniprot
proteins
pubmed
36848233
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:36848233}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:22361696}.
uniprot
proteins