Trim34a
entrez
94094
canonical
uniprot
Q99PP6
canonical
ensembl
ENSMUSG00000056144
resolver
ensp
ENSMUSP00000055058
resolver
ensp
ENSMUSP00000102461
resolver
ensp
ENSMUSP00000102462
resolver
genesymbol
Trim34a
resolver
uniprot
E9PYZ4
resolver
uniprot
F8VPK2
resolver
uniprot
Q99PP4
resolver
uniprot
Q99PP5
resolver
uniprot_entry
TR34A_MOUSE
resolver
uniprot_sec
E9PYZ4
resolver
uniprot_sec
F8VPK2
resolver
uniprot_sec
Q99PP4
resolver
uniprot_sec
Q99PP5
resolver
amino_acid_sequence
MASTGLTNIQEKTTCPVCQELLTKALSLGCGHRVCQACLITKKNAVINPREKSSCPVCGTRFSLENLQANKHLANVVERLGEVKLKPDIGTKRDLCVHHGEKLLLFCKEDKKAICWVCERSQEHRGHHTFLWEEAVRECQENLQKALTRLRKEQEKVETLEADIKEDRLSWKCQVQTERQRIQTGFNQLRRILDKEEQRELKRLREEEQMILDSLAGAEAELAQQSQLVEELISDLELRREWSDTELLQDMSGILKWSQIWTLKKPKAVSKKLSMVFQAPDLSGMLQKFRELTAVRAYWDNFTFNPENLNLNLILSEDHRQVTSVSIWPFKCCNNGILGSKCFSSGKHYWEVDVSEKKAWTLGVYTRKRTLRFDVRQRKGQPNGYHRYKPQNGYWVIGLQHGSKYSIFEDSSNCDPTVLNPFVATPLHRVGVFLDCEEGTVSFLNVTNHGSLIYKFSQCCFSQPAYPYFNPWDCPAPMTLCPLNS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Functions as antiviral protein and contributes to the defense against retroviral infections (By similarity). Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses. During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination. In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (By similarity). Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis. Also promotes the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (By similarity). Plays an essential role in sustaining the integrity of the inner mucus layer in the colon by controlling the exocytosis of the major component of colonic mucus MUC2 from colonic goblet cells (PubMed:32094504). {ECO:0000250|UniProtKB:Q9BYJ4, ECO:0000269|PubMed:32094504}.
uniprot
proteins
mass_dalton
55950
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9BYJ4}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
32094504
uniprot
proteins
sequence_length
485
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BYJ4}. Mitochondrion {ECO:0000250|UniProtKB:Q9BYJ4}.
uniprot
proteins