CHRM3
entrez
1131
canonical
uniprot
P20309
canonical
ensembl
ENSG00000133019
resolver
ensp
ENSP00000255380
resolver
ensp
ENSP00000482377
resolver
ensp
ENSP00000502013
resolver
ensp
ENSP00000502349
resolver
ensp
ENSP00000502667
resolver
ensp
ENSP00000545896
resolver
ensp
ENSP00000545897
resolver
ensp
ENSP00000545898
resolver
ensp
ENSP00000545899
resolver
ensp
ENSP00000545900
resolver
ensp
ENSP00000545901
resolver
ensp
ENSP00000545902
resolver
ensp
ENSP00000545903
resolver
ensp
ENSP00000545904
resolver
ensp
ENSP00000545905
resolver
ensp
ENSP00000545906
resolver
ensp
ENSP00000598319
resolver
ensp
ENSP00000598320
resolver
ensp
ENSP00000598321
resolver
ensp
ENSP00000598322
resolver
ensp
ENSP00000598323
resolver
ensp
ENSP00000598324
resolver
ensp
ENSP00000598325
resolver
ensp
ENSP00000598326
resolver
ensp
ENSP00000598327
resolver
ensp
ENSP00000619051
resolver
ensp
ENSP00000619052
resolver
ensp
ENSP00000619053
resolver
ensp
ENSP00000619054
resolver
enst
ENST00000255380
resolver
enst
ENST00000615928
resolver
enst
ENST00000675184
resolver
enst
ENST00000676153
resolver
enst
ENST00000676433
resolver
enst
ENST00000875837
resolver
enst
ENST00000875838
resolver
enst
ENST00000875839
resolver
enst
ENST00000875840
resolver
enst
ENST00000875841
resolver
enst
ENST00000875842
resolver
enst
ENST00000875843
resolver
enst
ENST00000875844
resolver
enst
ENST00000875845
resolver
enst
ENST00000875846
resolver
enst
ENST00000875847
resolver
enst
ENST00000928260
resolver
enst
ENST00000928261
resolver
enst
ENST00000928262
resolver
enst
ENST00000928263
resolver
enst
ENST00000928264
resolver
enst
ENST00000928265
resolver
enst
ENST00000928266
resolver
enst
ENST00000928267
resolver
enst
ENST00000928268
resolver
enst
ENST00000948992
resolver
enst
ENST00000948993
resolver
enst
ENST00000948994
resolver
enst
ENST00000948995
resolver
genesymbol
CHRM3
resolver
hgnc
HGNC:1952
resolver
uniprot
Q0VAJ8
resolver
uniprot
Q4QRI3
resolver
uniprot
Q5VXY2
resolver
uniprot
Q9HB60
resolver
uniprot_entry
ACM3_HUMAN
resolver
uniprot_sec
Q0VAJ8
resolver
uniprot_sec
Q4QRI3
resolver
uniprot_sec
Q5VXY2
resolver
uniprot_sec
Q9HB60
resolver
amino_acid_sequence
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
uniprot
proteins
disease_involvement
DISEASE: Prune belly syndrome (PBS) [MIM:100100]: A syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities. {ECO:0000269|PubMed:22077972}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. {ECO:0000269|PubMed:7565628}.
uniprot
proteins
mass_dalton
66128
uniprot
proteins
mutagenesis
MUTAGEN 276; /note="E->A: Loss of basolateral sorting."; /evidence="ECO:0000269|PubMed:15870063"; MUTAGEN 276; /note="E->D: Loss of basolateral sorting. No effect on basolateral sorting; when associated with L-280 and L-281."; /evidence="ECO:0000269|PubMed:15870063"; MUTAGEN 280; /note="F->A: Loss of basolateral sorting."; /evidence="ECO:0000269|PubMed:15870063"; MUTAGEN 280; /note="F->L: No effect on basolateral sorting."; /evidence="ECO:0000269|PubMed:15870063"; MUTAGEN 281; /note="V->A: Loss of basolateral sorting."; /evidence="ECO:0000269|PubMed:15870063"; MUTAGEN 281; /note="V->L: No effect on basolateral sorting."; /evidence="ECO:0000269|PubMed:15870063
uniprot
proteins
protein_family
CHRM3 sub-subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Muscarinic acetylcholine receptor subfamily
uniprot
proteins
pubmed
11238933
uniprot
proteins
pubmed
15014171
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15870063
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21056967
uniprot
proteins
pubmed
22077972
uniprot
proteins
pubmed
23521066
uniprot
proteins
pubmed
3272174
uniprot
proteins
pubmed
3443095
uniprot
proteins
pubmed
7565628
uniprot
proteins
sequence_length
590
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21056967}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:15870063}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21056967}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with TMEM147 in the endoplasmic reticulum (ER) membrane. TMEM147 impairs its trafficking to the cell membrane leading to its retention in the ER membrane. {ECO:0000269|PubMed:21056967}.
uniprot
proteins
transmembrane_region
TRANSMEM 68..91; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 105..130; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 143..164; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 185..206; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 230..252; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 492..514; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 527..546; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins