O55023
uniprot
O55023
canonical
activity_regulation
ACTIVITY REGULATION: Inhibited by Li(+), Ca(2+) and Mn(2+), but also by Mg(2+) at concentrations above 3 mM. {ECO:0000250|UniProtKB:P29218}.
uniprot
proteins
amino_acid_sequence
MADPWQECMDYAVILARQAGEMIREALKNEMDVMIKSSPADLVTVTDQKVEKMLMSSIKEKYPCHSFIGEESVAAGEKTVFTESPTWFIDPIDGTTNFVHRFPFVAVSIGFLVNKEMEFGIVYSCVEDKMYTGRKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRKPETLRIVLSNMEKLCSIPIHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDMAGAGIIVTEAGGVLMDVTGGPFDLMSRRIIAANSITLAKRIAKEIEIIPLQRDDES
uniprot
proteins
ec_number
3.1.3.25
uniprot
proteins
ec_number
3.1.3.94
uniprot
proteins
function
FUNCTION: Phosphatase involved in the dephosphorylation of myo-inositol monophosphate to generate myo-inositol. Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate. Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP. Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides, and involved in maintaining normal brain function. Has been implicated as the pharmacological target for lithium Li(+) action in brain. {ECO:0000250|UniProtKB:P29218}.
uniprot
proteins
mass_dalton
30436
uniprot
proteins
pathway_participation
PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
uniprot
proteins
protein_family
Inositol monophosphatase superfamily
uniprot
proteins
pubmed
12877981
uniprot
proteins
pubmed
17068342
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23027737
uniprot
proteins
sequence_length
277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P29218}.
uniprot
proteins