EHMT2
entrez
10919
canonical
uniprot
Q96KQ7
canonical
ensembl
ENSG00000204371
resolver
ensembl
ENSG00000206376
resolver
ensembl
ENSG00000227333
resolver
ensembl
ENSG00000232045
resolver
ensembl
ENSG00000236759
resolver
ensembl
ENSG00000238134
resolver
ensp
ENSP00000364678
resolver
ensp
ENSP00000364680
resolver
ensp
ENSP00000364687
resolver
ensp
ENSP00000379078
resolver
ensp
ENSP00000382886
resolver
ensp
ENSP00000382888
resolver
ensp
ENSP00000396119
resolver
ensp
ENSP00000397323
resolver
ensp
ENSP00000398286
resolver
ensp
ENSP00000400861
resolver
ensp
ENSP00000403402
resolver
ensp
ENSP00000416957
resolver
ensp
ENSP00000562754
resolver
ensp
ENSP00000562755
resolver
ensp
ENSP00000562756
resolver
enst
ENST00000375528
resolver
enst
ENST00000395728
resolver
enst
ENST00000400006
resolver
enst
ENST00000400008
resolver
enst
ENST00000420336
resolver
enst
ENST00000420930
resolver
enst
ENST00000421926
resolver
enst
ENST00000428442
resolver
enst
ENST00000436403
resolver
enst
ENST00000443951
resolver
genesymbol
EHMT2
resolver
genesymbol_syn
BAT8
resolver
genesymbol_syn
C6orf30
resolver
genesymbol_syn
G9A
resolver
genesymbol_syn
KMT1C
resolver
genesymbol_syn
NG36
resolver
hgnc
HGNC:14129
resolver
uniprot
A2ABF8
resolver
uniprot
A2ABF9
resolver
uniprot
B0UZY2
resolver
uniprot
B7Z852
resolver
uniprot
Q14349
resolver
uniprot
Q59FM7
resolver
uniprot
Q5JP83
resolver
uniprot
Q5JQ92
resolver
uniprot
Q5JQA1
resolver
uniprot
Q5JQG3
resolver
uniprot
Q6PK06
resolver
uniprot
Q96MH5
resolver
uniprot
Q96QD0
resolver
uniprot
Q9UQL8
resolver
uniprot
Q9Y331
resolver
uniprot_entry
A2ABF8_HUMAN
resolver
uniprot_entry
A2ABF9_HUMAN
resolver
uniprot_entry
B7Z852_HUMAN
resolver
uniprot_entry
EHMT2_HUMAN
resolver
uniprot_entry
Q59FM7_HUMAN
resolver
uniprot_sec
B0UZY2
resolver
uniprot_sec
Q14349
resolver
uniprot_sec
Q5JP83
resolver
uniprot_sec
Q5JQ92
resolver
uniprot_sec
Q5JQA1
resolver
uniprot_sec
Q5JQG3
resolver
uniprot_sec
Q6PK06
resolver
uniprot_sec
Q96MH5
resolver
uniprot_sec
Q96QD0
resolver
uniprot_sec
Q9UQL8
resolver
uniprot_sec
Q9Y331
resolver
amino_acid_sequence
MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.367
uniprot
proteins
function
FUNCTION: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones (PubMed:11316813, PubMed:20084102). Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication (PubMed:22387026). Also weakly methylates 'Lys-27' of histone H3 (H3K27me) (PubMed:11316813). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. Also able to mono- and dimethylate histone H1-4 at 'Lys-26' (H1.4K26me1 and H1.4K26me2, respectively) (PubMed:19144645). In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53 (PubMed:20118233). Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself (PubMed:18438403). {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:19144645, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026}.
uniprot
proteins
mass_dalton
132370
uniprot
proteins
mutagenesis
MUTAGEN 786; /note="W->A: Abolishes binding to histone H3K9me without affecting the histone methyltransferase activity."; /evidence="ECO:0000269|PubMed:18264113"; MUTAGEN 791; /note="W->A: Abolishes binding to histone H3K9me without affecting the histone methyltransferase activity."; /evidence="ECO:0000269|PubMed:18264113"; MUTAGEN 794; /note="E->A: Abolishes binding to histone H3K9me without affecting the histone methyltransferase activity."; /evidence="ECO:0000269|PubMed:18264113"; MUTAGEN 817; /note="E->R: Impairs binding to histone H3K9me."; /evidence="ECO:0000269|PubMed:18264113"; MUTAGEN 824; /note="W->A: Abolishes binding to histone H3K9me without affecting the histone methyltransferase activity."; /evidence="ECO:0000269|PubMed:18264113"; MUTAGEN 852; /note="D->R: Impairs binding to histone H3K9me."; /evidence="ECO:0000269|PubMed:18264113
uniprot
proteins
post_translational_modification
PTM: Methylated at Lys-185; automethylated. {ECO:0000269|PubMed:18438403}.
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
protein_family
Suvar3-9 subfamily
uniprot
proteins
pubmed
11316813
uniprot
proteins
pubmed
11707778
uniprot
proteins
pubmed
12004135
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16688220
uniprot
proteins
pubmed
16702210
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18264113
uniprot
proteins
pubmed
18438403
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19056828
uniprot
proteins
pubmed
19061646
uniprot
proteins
pubmed
19144645
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20084102
uniprot
proteins
pubmed
20118233
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21549307
uniprot
proteins
pubmed
22387026
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24900801
uniprot
proteins
pubmed
27648579
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
34278292
uniprot
proteins
pubmed
8457211
uniprot
proteins
sequence_length
1210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11316813}. Chromosome {ECO:0000269|PubMed:11316813}. Note=Associates with euchromatic regions (PubMed:11316813). Does not associate with heterochromatin (PubMed:11316813). {ECO:0000269|PubMed:11316813}.
uniprot
proteins