Acmsd
entrez
171385
canonical
uniprot
Q8R5M5
canonical
ensembl
ENSRNOG00000003884
resolver
ensembl
ENSRNOG00055012818
resolver
ensembl
ENSRNOG00060006187
resolver
ensembl
ENSRNOG00065009677
resolver
ensp
ENSRNOP00000081182
resolver
ensp
ENSRNOP00055017771
resolver
ensp
ENSRNOP00060007639
resolver
ensp
ENSRNOP00065011721
resolver
enst
ENSRNOT00000109111
resolver
enst
ENSRNOT00055021929
resolver
enst
ENSRNOT00060010243
resolver
enst
ENSRNOT00065015547
resolver
genesymbol
Acmsd
resolver
uniprot_entry
ACMSD_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Competitively inhibited by pyridine-2,6-dicarboxylic acid (PDC), a cyclic substrate analog. Oligomerization increases activity. {ECO:0000250|UniProtKB:Q8TDX5}.
uniprot
proteins
amino_acid_sequence
MKIDIHTHILPKEWPDLEKRFGYGGWVQLQQQGKGEAKMMKDGKVFRVIQQNCWDPEVRIREMNQKGVTVQALSTVPVMFSYWAKPKDTLELCQFLNNDLAATVARYPRRFVGLGTLPMQAPGLAVEEMERCVKELGFPGIQIGSHINMWDLNDPELFPIYTAAERLNCSLFVHPWDMQMDGRMAKYWLPWLVGMPSETTTAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTIGRIAHGFNMRPDLCARDNSSDPRKYLGSFYTDSLVHDPLSLKLLTDVIGKDRVILGTDYPFPLGEQEPGKLIESMADFDEETKDKLTAGNALTFLGLERKLFE
uniprot
proteins
ec_number
4.1.1.45
uniprot
proteins
function
FUNCTION: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS) (PubMed:11802786). ACMS can be converted non-enzymatically to quinolinate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway (By similarity). {ECO:0000250|UniProtKB:Q8TDX5, ECO:0000269|PubMed:11802786}.
uniprot
proteins
mass_dalton
38091
uniprot
proteins
protein_family
ACMSD family
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
pubmed
11802786
uniprot
proteins
pubmed
12140278
uniprot
proteins
sequence_length
336
uniprot
proteins