Inava
entrez
67313
canonical
uniprot
Q7TN12
canonical
ensembl
ENSMUSG00000041605
resolver
ensp
ENSMUSP00000113785
resolver
ensp
ENSMUSP00000257902
resolver
enst
ENSMUST00000120339
resolver
genesymbol
Inava
resolver
uniprot
G3X9Z8
resolver
uniprot
Q7TN27
resolver
uniprot
Q8BGK3
resolver
uniprot_entry
G3X9Z8_MOUSE
resolver
uniprot_entry
INAVA_MOUSE
resolver
uniprot_sec
Q7TN27
resolver
uniprot_sec
Q8BGK3
resolver
amino_acid_sequence
MLQMPKLNEIPPGRGGPGEPWGEGRWAGPTGPEAARPARGARGQARGARARWDSWEHSRLPTHPGPGWDQCSPSFLCAPSSQKLIMESKDEVSDSDSGIILQSGPDSPVSPMKELTNAVRKQQRALEARLEACLEELRRLCLREAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDEWALHREDPLSSLERQLALQLQITEAARRLCAEENLSRQARRQRKHAALQEEKKLRDLQRCLGDRRRNSEPPPTTVPSLGRELSASDDSSLSDGLLLEEEDSQAPKPPPESPAPPSRPLPPQSLEGLQPTGPESGGQERAPIQNSPWKETSLDHPYEKPRKSSELSSESSSPATTPQDQPNPSSLWVLDAASYHVVPIRNVPGQRQGRTSAPATPEMQGRRGQSQSLRVDSFRAGAEGRGRSAFPRRRPTHYTVTVPDSCFTPGKPPLPHPACHSCSEDSGSDVSSISHPTSPGSSSPDISFLRPLCLPEPPRHRGAWGPACGRELAPHYSKLLLPAGYFPTGRYVMVAEGHLPPGEWELCRAAVGAAYDEEGAPLRYQRLVPSHSRIVRTPSLKDSPAGRGLSKAAVSEELKWWHERARLRSSRPHSLDRQGAFRVRSLPPGRESFGRASGPRTQVPPVYVLRRSTDGAPVQVFVPENGEIISQV
uniprot
proteins
function
FUNCTION: Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (By similarity). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). {ECO:0000250|UniProtKB:Q3KP66, ECO:0000269|PubMed:29420262}.
uniprot
proteins
mass_dalton
72693
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
29420262
uniprot
proteins
sequence_length
663
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3KP66}. Cytoplasm {ECO:0000250|UniProtKB:Q3KP66}. Note=Translocates to the nucleus upon NOD2 stimulation. {ECO:0000250|UniProtKB:Q3KP66}.
uniprot
proteins