PXN
entrez
5829
canonical
uniprot
P49023
canonical
ensembl
ENSG00000089159
resolver
ensp
ENSP00000228307
resolver
ensp
ENSP00000267257
resolver
ensp
ENSP00000391283
resolver
ensp
ENSP00000395536
resolver
ensp
ENSP00000443887
resolver
ensp
ENSP00000489840
resolver
ensp
ENSP00000554848
resolver
ensp
ENSP00000554849
resolver
ensp
ENSP00000554850
resolver
ensp
ENSP00000554854
resolver
ensp
ENSP00000554856
resolver
ensp
ENSP00000554858
resolver
ensp
ENSP00000554861
resolver
ensp
ENSP00000586230
resolver
ensp
ENSP00000586233
resolver
ensp
ENSP00000637133
resolver
ensp
ENSP00000637134
resolver
ensp
ENSP00000644304
resolver
ensp
ENSP00000644306
resolver
enst
ENST00000536957
resolver
enst
ENST00000637617
resolver
genesymbol
PXN
resolver
hgnc
HGNC:9718
resolver
uniprot
A0A140VJQ8
resolver
uniprot
A0A1B0GTU4
resolver
uniprot
B2RAI3
resolver
uniprot
B7ZMB4
resolver
uniprot
F5GZ78
resolver
uniprot
O14970
resolver
uniprot
O14971
resolver
uniprot
O60360
resolver
uniprot
Q5HYA4
resolver
uniprot_entry
A0A140VJQ8_HUMAN
resolver
uniprot_entry
A0A1B0GTU4_HUMAN
resolver
uniprot_entry
F5GZ78_HUMAN
resolver
uniprot_entry
PAXI_HUMAN
resolver
uniprot_sec
B2RAI3
resolver
uniprot_sec
B7ZMB4
resolver
uniprot_sec
O14970
resolver
uniprot_sec
O14971
resolver
uniprot_sec
O60360
resolver
uniprot_sec
Q5HYA4
resolver
amino_acid_sequence
MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPSSEALNGTILDPLDQWQPSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEEEHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKIQGLEQRADGERCWAAGWPRDGGRSSPGGQDEGGFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC
uniprot
proteins
function
FUNCTION: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}.
uniprot
proteins
mass_dalton
64505
uniprot
proteins
mutagenesis
MUTAGEN 7..8; /note="LL->RR: Loss of interaction with PDCD10."; /evidence="ECO:0000269|PubMed:20489202
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility (PubMed:23128389). Phosphorylation at Ser-272 promotes focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000250, ECO:0000269|PubMed:11774284, ECO:0000269|PubMed:15572663, ECO:0000269|PubMed:18042622, ECO:0000269|PubMed:23128389, ECO:0000269|PubMed:26598620}.
uniprot
proteins
protein_family
Paxillin family
uniprot
proteins
pubmed
10604475
uniprot
proteins
pubmed
10749932
uniprot
proteins
pubmed
10938112
uniprot
proteins
pubmed
11035932
uniprot
proteins
pubmed
11774284
uniprot
proteins
pubmed
12861019
uniprot
proteins
pubmed
14527389
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15572663
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15817463
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17297458
uniprot
proteins
pubmed
17462669
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18042622
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18508764
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18940607
uniprot
proteins
pubmed
19358827
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20037584
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20489202
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22869380
uniprot
proteins
pubmed
23128389
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24694988
uniprot
proteins
pubmed
25015296
uniprot
proteins
pubmed
26598620
uniprot
proteins
pubmed
37316325
uniprot
proteins
pubmed
7534286
uniprot
proteins
pubmed
9054445
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20489202}. Cell junction, focal adhesion {ECO:0000269|PubMed:20489202, ECO:0000269|PubMed:23128389, ECO:0000269|PubMed:25015296}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q8VI36}. Note=Colocalizes with integrins at the cell periphery. Colocalize with PXN to membrane ruffles and the leading edge of migrating cells (PubMed:23128389). {ECO:0000250, ECO:0000269|PubMed:23128389}.
uniprot
proteins