ITGB6
entrez
3694
canonical
uniprot
P18564
canonical
ensembl
ENSG00000115221
resolver
ensp
ENSP00000283249
resolver
ensp
ENSP00000386367
resolver
ensp
ENSP00000386828
resolver
ensp
ENSP00000408024
resolver
ensp
ENSP00000481183
resolver
enst
ENST00000428609
resolver
enst
ENST00000620391
resolver
genesymbol
ITGB6
resolver
hgnc
HGNC:6161
resolver
uniprot
A0A087WXP3
resolver
uniprot
B2R9W5
resolver
uniprot
B4E2B8
resolver
uniprot
C9JA97
resolver
uniprot
E9PEE8
resolver
uniprot
Q0VA95
resolver
uniprot
Q16500
resolver
uniprot
Q53RG5
resolver
uniprot
Q53RR6
resolver
uniprot_entry
A0A087WXP3_HUMAN
resolver
uniprot_entry
B4E2B8_HUMAN
resolver
uniprot_entry
E9PEE8_HUMAN
resolver
uniprot_entry
ITB6_HUMAN
resolver
uniprot_sec
B2R9W5
resolver
uniprot_sec
C9JA97
resolver
uniprot_sec
Q0VA95
resolver
uniprot_sec
Q16500
resolver
uniprot_sec
Q53RG5
resolver
uniprot_sec
Q53RR6
resolver
amino_acid_sequence
MGIELLCLFFLFLGRNDHVQGGCALGGAETCEDCLLIGPQCAWCAQENFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKNKPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNSSKCHHGNGSFQCGVCACHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGGNGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQAREECVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKQKVDLSTDC
uniprot
proteins
disease_involvement
DISEASE: Amelogenesis imperfecta 1H (AI1H) [MIM:616221]: A disorder characterized by defective enamel formation, resulting in hypoplastic and hypomineralized tooth enamel that may be rough, pitted, and/or discolored. {ECO:0000269|PubMed:24305999, ECO:0000269|PubMed:24319098}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17158881, PubMed:17545607). It recognizes the sequence R-G-D in its ligands (PubMed:17158881, PubMed:17545607). Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17158881, PubMed:17545607). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:17545607, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:25383667, ECO:0000269|PubMed:28117447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1. {ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:9426447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260). {ECO:0000269|PubMed:24367260}.
uniprot
proteins
mass_dalton
85936
uniprot
proteins
protein_family
Integrin beta chain family
uniprot
proteins
pubmed
11807098
uniprot
proteins
pubmed
1382574
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15184403
uniprot
proteins
pubmed
15194773
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17158881
uniprot
proteins
pubmed
17545607
uniprot
proteins
pubmed
22278742
uniprot
proteins
pubmed
2365683
uniprot
proteins
pubmed
24305999
uniprot
proteins
pubmed
24319098
uniprot
proteins
pubmed
24367260
uniprot
proteins
pubmed
25383667
uniprot
proteins
pubmed
28117447
uniprot
proteins
pubmed
9426447
uniprot
proteins
sequence_length
788
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17545607}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, focal adhesion {ECO:0000269|PubMed:17158881}.
uniprot
proteins
transmembrane_region
TRANSMEM 710..730; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins