AK4
entrez
205
canonical
uniprot
P27144
canonical
ensembl
ENSG00000162433
resolver
ensp
ENSP00000322175
resolver
ensp
ENSP00000378743
resolver
ensp
ENSP00000445912
resolver
ensp
ENSP00000448458
resolver
ensp
ENSP00000570868
resolver
ensp
ENSP00000570869
resolver
ensp
ENSP00000570870
resolver
ensp
ENSP00000570874
resolver
ensp
ENSP00000608073
resolver
ensp
ENSP00000608074
resolver
ensp
ENSP00000608075
resolver
ensp
ENSP00000627502
resolver
enst
ENST00000327299
resolver
enst
ENST00000395334
resolver
enst
ENST00000545314
resolver
enst
ENST00000546702
resolver
enst
ENST00000900809
resolver
enst
ENST00000900810
resolver
enst
ENST00000900811
resolver
enst
ENST00000900815
resolver
enst
ENST00000938014
resolver
enst
ENST00000938015
resolver
enst
ENST00000938016
resolver
enst
ENST00000957443
resolver
genesymbol
AK4
resolver
genesymbol_syn
AK3
resolver
genesymbol_syn
AK3L1
resolver
hgnc
HGNC:363
resolver
uniprot
B2R927
resolver
uniprot
D3DQ62
resolver
uniprot
F8VS11
resolver
uniprot
Q6IBH4
resolver
uniprot
Q6NXQ5
resolver
uniprot
Q8IUU9
resolver
uniprot_entry
F8VS11_HUMAN
resolver
uniprot_entry
KAD4_HUMAN
resolver
uniprot_sec
B2R927
resolver
uniprot_sec
D3DQ62
resolver
uniprot_sec
Q6IBH4
resolver
uniprot_sec
Q6NXQ5
resolver
uniprot_sec
Q8IUU9
resolver
amino_acid_sequence
MASKLLRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELENRRGQHWLLDGFPRTLGQAEALDKICEVDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTETNKIWPYVYTLFSNKITPIQSKEAY
uniprot
proteins
ec_number
2.7.4.4
uniprot
proteins
ec_number
2.7.4.6
uniprot
proteins
function
FUNCTION: Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions (PubMed:19073142, PubMed:19766732, PubMed:23416111, PubMed:24767988). Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP (PubMed:19766732). Phosphorylates only AMP when using GTP as phosphate donor (PubMed:19766732). In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor (PubMed:19766732, PubMed:23416111). Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors (PubMed:23416111). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (PubMed:24767988, PubMed:26980435). Plays a protective role in the cellular response to oxidative stress (PubMed:19130895, PubMed:23474458, PubMed:26980435). {ECO:0000269|PubMed:19073142, ECO:0000269|PubMed:19130895, ECO:0000269|PubMed:19766732, ECO:0000269|PubMed:23416111, ECO:0000269|PubMed:23474458, ECO:0000269|PubMed:24767988, ECO:0000269|PubMed:26980435}.
uniprot
proteins
mass_dalton
25268
uniprot
proteins
mutagenesis
MUTAGEN 4; /note="K->G: Abolishes mitochondrial import; when associated with G-7."; /evidence="ECO:0000269|PubMed:19766732"; MUTAGEN 7; /note="R->G: Abolishes mitochondrial import; when associated with G-4."; /evidence="ECO:0000269|PubMed:19766732
uniprot
proteins
protein_family
AK3 subfamily
uniprot
proteins
protein_family
Adenylate kinase family
uniprot
proteins
pubmed
11485571
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1639383
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19073142
uniprot
proteins
pubmed
19130895
uniprot
proteins
pubmed
19766732
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23416111
uniprot
proteins
pubmed
23474458
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24767988
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26980435
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03170, ECO:0000269|PubMed:11485571, ECO:0000269|PubMed:19766732, ECO:0000269|PubMed:26980435}.
uniprot
proteins