Crbn
entrez
58799
canonical
uniprot
Q8C7D2
canonical
ensembl
ENSMUSG00000005362
resolver
ensp
ENSMUSP00000013882
resolver
ensp
ENSMUSP00000108865
resolver
genesymbol
Crbn
resolver
uniprot
Q3TVC2
resolver
uniprot
Q5RJV6
resolver
uniprot
Q6IS49
resolver
uniprot
Q80XJ1
resolver
uniprot
Q8BP45
resolver
uniprot
Q8C6B7
resolver
uniprot
Q9JKR4
resolver
uniprot_entry
CRBN_MOUSE
resolver
uniprot_sec
Q3TVC2
resolver
uniprot_sec
Q5RJV6
resolver
uniprot_sec
Q6IS49
resolver
uniprot_sec
Q80XJ1
resolver
uniprot_sec
Q8BP45
resolver
uniprot_sec
Q8C6B7
resolver
uniprot_sec
Q9JKR4
resolver
amino_acid_sequence
MAGEGDQQDAAHNMGNHLPLLPADSEDEDDEIEMEVEDQDSKEARKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPEVLMILIPGQTLPLQLSHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQEFGIEVVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQVFPSKPISWEDQYSCKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPENPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPETEDEISPDKVILCL
uniprot
proteins
function
FUNCTION: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2, ILF2, GLUL, IKZF1 and CSNK1A1 (By similarity). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). Maintains presynaptic glutamate release and consequently, cognitive functions such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons (PubMed:29530986). Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (By similarity). May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (PubMed:29530986). Plays a negative role in TLR4 signaling by interacting with TRAF6 and ECSIT, leading to inhibition of ECSIT ubiquitination, an important step of the signaling (By similarity). {ECO:0000250|UniProtKB:Q96SW2, ECO:0000269|PubMed:29530986}.
uniprot
proteins
mass_dalton
50880
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q96SW2}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, ubiquitination is mediated by its own DCX protein ligase complex. {ECO:0000250|UniProtKB:Q96SW2}.
uniprot
proteins
protein_family
CRBN family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20131966
uniprot
proteins
pubmed
21995942
uniprot
proteins
pubmed
25108355
uniprot
proteins
pubmed
29530986
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96SW2}. Nucleus {ECO:0000250|UniProtKB:Q96SW2}. Membrane {ECO:0000250|UniProtKB:Q56AP7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q56AP7}.
uniprot
proteins