Nsmce2
entrez
68501
canonical
uniprot
Q91VT1
canonical
ensembl
ENSMUSG00000059586
resolver
ensp
ENSMUSP00000078641
resolver
ensp
ENSMUSP00000128893
resolver
ensp
ENSMUSP00000154811
resolver
ensp
ENSMUSP00000280041
resolver
ensp
ENSMUSP00000341695
resolver
enst
ENSMUST00000227173
resolver
genesymbol
Nsmce2
resolver
genesymbol_syn
Mms21
resolver
uniprot
A0A2I3BS18
resolver
uniprot
Q8BQ88
resolver
uniprot
Q9D1D3
resolver
uniprot_entry
A0A2I3BS18_MOUSE
resolver
uniprot_entry
NSE2_MOUSE
resolver
uniprot_sec
Q8BQ88
resolver
uniprot_sec
Q9D1D3
resolver
amino_acid_sequence
MPGRSSTSSGSTRYISFSGIESALSSLKNFQSCISSGMDTVSSVALDLVETQTEVSSEYSMDKAMVEFAKMDRELSHYVKAVQSTINHVKEERPEKVPDLKLLVEKKFLALQDKNSDADFKENEKFVQFKQQLRELKKQYGIHADRENDLTEGVDEDMIVTQSQTNFICPITQLEMKKPVKNKMCGHTYEEEAIVRMIESKHKRKKKACCPKIGCSHTDMRMSDLIPDEALRRAIESHNKKKKRHSE
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
function
FUNCTION: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression. {ECO:0000250|UniProtKB:Q96MF7}.
uniprot
proteins
mass_dalton
28231
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein sumoylation. {ECO:0000250|UniProtKB:Q96MF7}.
uniprot
proteins
post_translational_modification
PTM: Sumoylated, possibly via autosumoylation. {ECO:0000250|UniProtKB:Q96MF7}.
uniprot
proteins
protein_family
NSE2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96MF7}. Chromosome, telomere {ECO:0000250|UniProtKB:Q96MF7}. Nucleus, PML body {ECO:0000250|UniProtKB:Q96MF7}. Note=Localizes to PML nuclear bodies in ALT cell lines. {ECO:0000250|UniProtKB:Q96MF7}.
uniprot
proteins