Pex12
entrez
116718
canonical
uniprot
O88177
canonical
ensembl
ENSRNOG00000009718
resolver
ensembl
ENSRNOG00055029462
resolver
ensembl
ENSRNOG00060028884
resolver
ensembl
ENSRNOG00065021081
resolver
ensp
ENSRNOP00000013233
resolver
ensp
ENSRNOP00055042037
resolver
ensp
ENSRNOP00060041808
resolver
ensp
ENSRNOP00065028899
resolver
enst
ENSRNOT00000013233
resolver
enst
ENSRNOT00055051036
resolver
enst
ENSRNOT00060050172
resolver
enst
ENSRNOT00065035840
resolver
genesymbol
Pex12
resolver
genesymbol_syn
Paf3
resolver
uniprot_entry
PEX12_RAT
resolver
amino_acid_sequence
MAEHGAHITTASVADDQPSIFEVVAQDSLMTAVRPALQHVVKVLAESNPAHYGFFWRWFDEIFTLLDFLLQQHYLSRTSASFSEHFYGLKRIVAGSSPQLQRPASAGLPKEHLWKSAMFLVLLPYLKVKLEKLASTLREEDEYSIHPPSSHWKRFYRVFLAAYPFVTMTWEGWFLTQQLRYILGKAEHHSPLLKLAGVRLGRLTAQDIQAMEHRLVEASAMQEPVRSIGKKIKSALKKAVGGVALSLSTGLSVGVFFLQFLDWWYSSENQETIKSLTALPTPPPPVHLDYNSDSPLLPKMKTVCPLCRKARVNDTVLATSGYVFCYRCVFNYVRSHQACPITGYPTEVQHLIKLYSPEN
uniprot
proteins
function
FUNCTION: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity). {ECO:0000250|UniProtKB:O00623, ECO:0000250|UniProtKB:Q04370}.
uniprot
proteins
mass_dalton
40681
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:O00623}.
uniprot
proteins
protein_family
Pex2/pex10/pex12 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9354782
uniprot
proteins
pubmed
9632816
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:9354782}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..47; /note="Helical; Name=TM1"; /evidence="ECO:0000250|UniProtKB:G2Q5N0"; TRANSMEM 52..76; /note="Helical; Name=TM2"; /evidence="ECO:0000250|UniProtKB:G2Q5N0"; TRANSMEM 110..139; /note="Helical; Name=TM3"; /evidence="ECO:0000250|UniProtKB:G2Q5N0"; TRANSMEM 145..183; /note="Helical; Name=TM4"; /evidence="ECO:0000250|UniProtKB:G2Q5N0"; TRANSMEM 250..277; /note="Helical; Name=TM5"; /evidence="ECO:0000250|UniProtKB:G2Q5N0
uniprot
proteins