TRPC4
entrez
7223
canonical
uniprot
Q9UBN4
canonical
ensembl
ENSG00000133107
resolver
ensp
ENSP00000342580
resolver
ensp
ENSP00000348025
resolver
ensp
ENSP00000351264
resolver
ensp
ENSP00000368995
resolver
ensp
ENSP00000369027
resolver
ensp
ENSP00000486109
resolver
genesymbol
TRPC4
resolver
hgnc
HGNC:12336
resolver
uniprot
B1ALE0
resolver
uniprot
B1ALE1
resolver
uniprot
B1ALE2
resolver
uniprot
Q15721
resolver
uniprot
Q3SWS6
resolver
uniprot
Q96P03
resolver
uniprot
Q96P04
resolver
uniprot
Q96P05
resolver
uniprot
Q9UIB0
resolver
uniprot
Q9UIB1
resolver
uniprot
Q9UIB2
resolver
uniprot_entry
TRPC4_HUMAN
resolver
uniprot_sec
B1ALE0
resolver
uniprot_sec
B1ALE1
resolver
uniprot_sec
B1ALE2
resolver
uniprot_sec
Q15721
resolver
uniprot_sec
Q3SWS6
resolver
uniprot_sec
Q96P03
resolver
uniprot_sec
Q96P04
resolver
uniprot_sec
Q96P05
resolver
uniprot_sec
Q9UIB0
resolver
uniprot_sec
Q9UIB1
resolver
uniprot_sec
Q9UIB2
resolver
activity_regulation
ACTIVITY REGULATION: May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G protein coupled receptors (PubMed:11042129, PubMed:11713258, PubMed:16144838, PubMed:19996314). May be activated by intracellular calcium store depletion (By similarity). Inhibited by xanthine-based inhibitor Pico145 (PubMed:39478185). {ECO:0000250|UniProtKB:Q9QUQ5, ECO:0000269|PubMed:11042129, ECO:0000269|PubMed:11713258, ECO:0000269|PubMed:16144838, ECO:0000269|PubMed:19996314, ECO:0000269|PubMed:39478185}.
uniprot
proteins
amino_acid_sequence
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRKVNFVTDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL
uniprot
proteins
function
FUNCTION: Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11042129, PubMed:11713258, PubMed:16144838, PubMed:39478185). Acts as a cell-cell contact-dependent endothelial calcium entry channel (PubMed:19996314). Forms a homomeric ion channel or a heteromeric ion channel with TRPC1; the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel (PubMed:39478185). Also permeable to monovalent ions including sodium, lithium and cesium ions (PubMed:39478185). {ECO:0000250|UniProtKB:Q9QUQ5, ECO:0000269|PubMed:11042129, ECO:0000269|PubMed:11713258, ECO:0000269|PubMed:16144838, ECO:0000269|PubMed:19996314, ECO:0000269|PubMed:39478185}.; FUNCTION: [Isoform Beta]: Forms a receptor-activated non-selective calcium permeant cation channel. {ECO:0000269|PubMed:11713258}.
uniprot
proteins
mass_dalton
112101
uniprot
proteins
mutagenesis
MUTAGEN 959; /note="Y->F: Reduced EGF-induced phosphorylation and decreased association with NHERF1. Loss of EGF-induced phosphorylation and decreased association with NHERF1; when associated with F-972."; /evidence="ECO:0000269|PubMed:16144838"; MUTAGEN 972; /note="Y->F: Reduced EGF-induced phosphorylation and decreased association with NHERF1. Loss of EGF-induced phosphorylation and decreased association with NHERF1; when associated with F-959."; /evidence="ECO:0000269|PubMed:16144838"; MUTAGEN 975..977; /note="Missing: Loss of interaction with NHERF1."; /evidence="ECO:0000269|PubMed:12154080
uniprot
proteins
post_translational_modification
PTM: Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with NHERF1. {ECO:0000269|PubMed:16144838}.
uniprot
proteins
protein_family
STrpC subfamily
uniprot
proteins
protein_family
TRPC4 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
11042129
uniprot
proteins
pubmed
11163362
uniprot
proteins
pubmed
11713258
uniprot
proteins
pubmed
12032305
uniprot
proteins
pubmed
12154080
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15757897
uniprot
proteins
pubmed
16144838
uniprot
proteins
pubmed
16254212
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17850865
uniprot
proteins
pubmed
18048348
uniprot
proteins
pubmed
19996314
uniprot
proteins
pubmed
20164195
uniprot
proteins
pubmed
39478185
uniprot
proteins
pubmed
8646775
uniprot
proteins
sequence_length
977
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11042129, ECO:0000269|PubMed:11713258, ECO:0000269|PubMed:12154080, ECO:0000269|PubMed:16144838, ECO:0000269|PubMed:16254212}; Multi-pass membrane protein {ECO:0000269|PubMed:39478185}. Note=Enhanced insertion into the cell membrane after activation of the EGF receptor. {ECO:0000269|PubMed:16144838}.; SUBCELLULAR LOCATION: [Isoform Beta]: Cell membrane {ECO:0000269|PubMed:11713258}; Multi-pass membrane protein {ECO:0000269|PubMed:39478185}.
uniprot
proteins
transmembrane_region
TRANSMEM 363..383; /note="Helical; Name=S1"; /evidence="ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM, ECO:0007744|PDB:8WPN"; TRANSMEM 404..418; /note="Helical; Name=S2"; /evidence="ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM, ECO:0007744|PDB:8WPN"; TRANSMEM 433..453; /note="Helical; Name=S3"; /evidence="ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM, ECO:0007744|PDB:8WPN"; TRANSMEM 476..498; /note="Helical; Name=S4"; /evidence="ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM, ECO:0007744|PDB:8WPN"; TRANSMEM 512..534; /note="Helical; Name=S5"; /evidence="ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM, ECO:0007744|PDB:8WPN"; TRANSMEM 600..620; /note="Helical; Name=S6"; /evidence="ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM, ECO:0007744|PDB:8WPN
uniprot
proteins