Mcl1
entrez
17210
canonical
uniprot
P97287
canonical
ensembl
ENSMUSG00000038612
resolver
ensp
ENSMUSP00000044048
resolver
genesymbol
Mcl1
resolver
uniprot
D2K6L9
resolver
uniprot
Q3TUS0
resolver
uniprot
Q792P0
resolver
uniprot
Q9CRI4
resolver
uniprot_entry
MCL1_MOUSE
resolver
uniprot_sec
D2K6L9
resolver
uniprot_sec
Q3TUS0
resolver
uniprot_sec
Q792P0
resolver
uniprot_sec
Q9CRI4
resolver
amino_acid_sequence
MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREGGGEAALLPGARVVARPPPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPEAIGKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVTNWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
uniprot
proteins
function
FUNCTION: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity. {ECO:0000269|PubMed:16543145, ECO:0000269|PubMed:19919825}.
uniprot
proteins
mass_dalton
35217
uniprot
proteins
post_translational_modification
PTM: Cleaved by CASP3 during apoptosis, yielding a pro-apoptotic C-terminal fragment. {ECO:0000250}.; PTM: Rapidly degraded in the absence of phosphorylation in the PEST region. {ECO:0000250}.; PTM: Phosphorylated on Ser-140, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-140 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites. {ECO:0000269|PubMed:16543145}.; PTM: Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-140 (By similarity). Deubiquitinated by USP20; leading to increased stability. {ECO:0000250|UniProtKB:Q07820}.
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15550399
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16543145
uniprot
proteins
pubmed
18589438
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19919825
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21502331
uniprot
proteins
pubmed
21546903
uniprot
proteins
pubmed
27013495
uniprot
proteins
pubmed
9655929
uniprot
proteins
pubmed
9671497
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Mitochondrion. Nucleus, nucleoplasm {ECO:0000250}. Note=Cytoplasmic, associated with mitochondria.
uniprot
proteins
transmembrane_region
TRANSMEM 308..330; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins