Reln
entrez
24718
canonical
uniprot
P58751
canonical
ensembl
ENSRNOG00000021441
resolver
ensp
ENSRNOP00000010521
resolver
ensp
ENSRNOP00000058574
resolver
ensp
ENSRNOP00000099957
resolver
enst
ENSRNOT00000129632
resolver
genesymbol
Reln
resolver
uniprot
A0ABK0KYD2
resolver
uniprot
Q80T65
resolver
uniprot_entry
A0ABK0KYD2_RAT
resolver
uniprot_entry
RELN_RAT
resolver
uniprot_sec
Q80T65
resolver
amino_acid_sequence
MERGCWAPRTLVLAVLLLLLATLRARAATGYYPRFSPFFFLCTHHGELEGDGEQGEVLISLHIAGNPTYYVPGQEYHVTISTSTFFDGLLVTGLYTSTSIQSSQSIGGSSAFGFGIMSDHQFGNQFMCSVVASHVSHLPTTNLSFVWIAPPAGTGCVNFMATATHRGQVIFKDALAQQLCEQGAPTEATAYSHLAEIHSDSVILRDDFDSYHQLELNPNIWAECSNCDTGEQCGTIMHGNAVTFCEPYGPRELTTTYLNTTTASVLQFSIGSGSCRFSYSDPSIIVSYAKNNTADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQDSLHVGEVYEACWALDNILVINSAHRQVILEDSLDPVDTGNWLFFPGATVKHSCQSDGNAIYFHGNEGSQLNFATTRDVDLSTEDIQEQWSEEFESQPTGWDILGAVVGSECGTIESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFAMGGTCDPGDSHENDVILYAKIEGKKEHIALDTLSYSSYKVPTLVSVVINPELQTPATKFCLRQKNHQGHNQNVWAVDFFHVLPILPSTMSHMIQFSINLGCGTHQPGNSVSLEFSTNHGRSWSLLHTECLPEICAGPHLPHSTIYSSENYSGWNRVTIPLPNAALTRDTRIRWRQTGPILGNMWAIDNVYIGPSCLKFCSGRGQCTRHGCKCDPGFSGPACEMASQTFPMFISESFGSSRLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRAPDQPGEGVLLHYSYDNGITWKLLEHYSYLNYHEPRIISVELPDDAKQFGIQFRWWQPYHSSQGEDVWAIDEILMTSVLFNSISLDFTNLVEVTQSLGFYLGNIQPYCGHDWTLCFTGDSKLASSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDNQVKLEYSTNHGLTWHLVQDECLPSMPSCQEFTSASIYHASEFTQWRRVTVILPQKTWSGATRFRWSQSYYTAQDEWALDDIYIGQQCPNMCSGHGSCDHGVCRCDQGYQGTECHPEAALPSTIMSDFENPSSWDSDWQEVIGGEVVKPEQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESAACNKPDSREEGVLLQYSNNGGIQWHLLAEMYFSDFGKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIIILSEKQKQVIPVVNPTLPQNFYEKPAFDYPINQMSVWLMLANEGMAKNDSFCATTPSAMVFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCASQFSSTAPVLLQYSHDAGMSWFLVKEGCFPASAGKGCEGNSRELSEPTVYYTGDFEEWTRVTIAIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYISEPCPSYCSGHGDCISGVCFCDLGYTAAQGTCVSNIPNHSEMFDRFEGKLSPLWYKISGGQVGTGCGTLSDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPRARNEGLVVQYSNDNGILWHLLRELDFLSFLEPQIISIDLPREAKTPATAFRWWQPQHGKHSAQWALDDVLIGVNDSSQTGFQDKFDGSIDLQANWYRIQGGQVDIDCLSMDTALIFTENIGKPRYAETWDFHVSASSFLQFDMSMGCSKPFSATHSVQLQYSLNNGKDWHPVTEECVPPTIGCVHYTESSTYTSERFQNWRRVTVYLPLATNSPRTRFRWIQANYTMGADAWAIDNVLLASGCPWLCSGRGICDSGRCVCDRGFGGPFCVPVVPLPSILKDDFNGNLHPDLWPEVYGAERGNLNGETIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKGTPERSHSILLQSSINGGVTWRLMDEFYFPQTTSILFINVPLPYSAQTNATRFRLWQPYNNGKKEEIWIIDDFIIDGDNLNNPVMLLDTFDFGPREDNWFFYPGGNIGLYCPYSSKGAPEEDSAMVFVSNEIGEHSITTRDLSVNENTIIQFEINVGCSTDSSSADPVRLEFSRDFGATWHLLLPLCYHSSSLVSSLCSTEHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSQPVTWAIDNVYIGPQCEEMCCGHGSCVNGTKCICDPGYSGPTCKISTKNPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLGCGKGVPDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVGRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIGGNISGNTVLEDDFSTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVTTDIAVNEDSFLQIDFAASCSVTDSCYAIELEYSVDLGLSWHPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPAYTRSQATRFRWHQPAPFDKQQTWAIDNVYIGDGCLDMCSGHGRCIQGSCVCDEQWGGLYCDEPETSLPTQLKDNFNRAPSNQNWLTVNGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPSNRNQGVLLEYSVNGGITWTLLMEIFYDQYSKPGFVNILLPPDAKEIGTRFRWWQPRHDGLDQNDWAIDNVLISGSADQRTVMLDTFSSAPVPQHERSPADAGPVGRIAFDMFMEDKTSVNENWVFHDDCTVERFCDSPDGVMLCGSHDGREVYAVTHDLTPTENWIMQFKISVGCKVPEKIAQNQIHVQFSTDFGVSWSYLVPQCLPADPKCSGTVSQPSVFFPTKGWKRITYPLPESLMGNPVRFRFYQKYSDVQWAIDNFYLGPGCLDNCGGHGDCLKEQCICDPGYSGPHCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGSENNMTSCHRPVCRKEGVLLDYSKDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPFVISNGLVVSGVERAQWALDNILIGGAEINPSQLVDTFDDEGSSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVGCEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNAVNSSSWKRITIQLPDHVSSSATQFRWIQKGEETEKQSWAIDHVYIGEACPRLCSGHGYCTTGAVCICDESFQGDDCSVFSHELPSYIKDNFESARVTEANWETIQGGAIGSGCGQLAPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSTAQTDSCNSDLSGPHTVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHVEVVLVSTRKQNYMMNFSRQHGLRHFYNRRRRSLRRYP
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Reln are the cause of the creeping phenotype, which is characterized by tremor, gait ataxia, cerebellar hypoplasia and abnormal neuronal migration (particularly in the cerebral cortex and hippocampus). The mutation is due to a nucleotide insertion at codon 1892 which results in a translational frameshift and truncation of the protein. {ECO:0000269|PubMed:12670697}.
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. {ECO:0000250|UniProtKB:Q60841}.
uniprot
proteins
mass_dalton
387531
uniprot
proteins
post_translational_modification
PTM: N-glycosylated and to a lesser extent also O-glycosylated. {ECO:0000250|UniProtKB:Q60841}.
uniprot
proteins
protein_family
Reelin family
uniprot
proteins
pubmed
10328932
uniprot
proteins
pubmed
12670697
uniprot
proteins
sequence_length
3462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q60841}.
uniprot
proteins