SLC7A8
entrez
23428
canonical
uniprot
Q9UHI5
canonical
ensembl
ENSG00000092068
resolver
ensp
ENSP00000320378
resolver
ensp
ENSP00000391577
resolver
ensp
ENSP00000416398
resolver
ensp
ENSP00000434345
resolver
genesymbol
SLC7A8
resolver
genesymbol_syn
LAT2
resolver
hgnc
HGNC:11066
resolver
uniprot
B2R8Q4
resolver
uniprot
B4DKT4
resolver
uniprot
B4DTV6
resolver
uniprot
D3DS46
resolver
uniprot
F2Z2J4
resolver
uniprot
Q53EM9
resolver
uniprot
Q86U05
resolver
uniprot
Q9UKQ6
resolver
uniprot
Q9UKQ7
resolver
uniprot
Q9UKQ8
resolver
uniprot
Q9Y445
resolver
uniprot_entry
LAT2_HUMAN
resolver
uniprot_entry
Q53EM9_HUMAN
resolver
uniprot_sec
B2R8Q4
resolver
uniprot_sec
B4DKT4
resolver
uniprot_sec
B4DTV6
resolver
uniprot_sec
D3DS46
resolver
uniprot_sec
F2Z2J4
resolver
uniprot_sec
Q86U05
resolver
uniprot_sec
Q9UKQ6
resolver
uniprot_sec
Q9UKQ7
resolver
uniprot_sec
Q9UKQ8
resolver
uniprot_sec
Q9Y445
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the L-type inhibitor 2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH). {ECO:0000269|PubMed:15081149}.
uniprot
proteins
amino_acid_sequence
MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEVERGSGTEEANEDMEEQQQPMYQPTPTKDKDVAGQPQP
uniprot
proteins
function
FUNCTION: Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1. Functions as amino acid antiporter mediating the influx of extracellular essential amino acids mainly in exchange with the efflux of highly concentrated intracellular amino acids (PubMed:10391915, PubMed:11311135, PubMed:11847106, PubMed:12716892, PubMed:15081149, PubMed:15918515, PubMed:29355479, PubMed:33298890, PubMed:34848541). Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter (PubMed:11847106). This asymmetry allows SLC7A8 to regulate intracellular amino acid pools (mM concentrations) by exchange with external amino acids (uM concentration range), equilibrating the relative concentrations of different amino acids across the plasma membrane instead of mediating their net uptake (PubMed:10391915, PubMed:11847106). May play an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney (PubMed:12716892). Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (PubMed:15769744). Imports the thyroid hormone diiodothyronine (T2) and to a smaller extent triiodothyronine (T3) but not rT 3 or thyroxine (T4) (PubMed:26305885). Mediates the uptake of L-DOPA (By similarity). May participate in auditory function (By similarity). Mediates the uptake of leucine and 3-iodo-L-tyrosine (MIT) (PubMed:26305885). Mediates the uptake of 3,5-diiodo-L-tyrosine (DIT) (PubMed:38661522). {ECO:0000250|UniProtKB:Q9QXW9, ECO:0000250|UniProtKB:Q9WVR6, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11847106, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15081149, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15918515, ECO:0000269|PubMed:26305885, ECO:0000269|PubMed:29355479, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:34848541, ECO:0000269|PubMed:38661522}.
uniprot
proteins
mass_dalton
58382
uniprot
proteins
mutagenesis
MUTAGEN 93; /note="Y->A: Nearly complete reduction of glycine, L-alanine, and L-glutamine uptake. Minimal effect on the transport of L-isoleucine, L-histidine and L-tryptophan."; /evidence="ECO:0000269|PubMed:34848541"; MUTAGEN 134; /note="N->Q: Reduces L-leucine uptake activity. Abolishes L-tryptophan uptake."; /evidence="ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:34848541"; MUTAGEN 134; /note="N->S: The substrate specificity changed dramatically reducing L-glutamine, glycine and L-alanine uptake activity thus mimicking the selectivity of SLC7A5."; /evidence="ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:34848541"; MUTAGEN 174; /note="W->A: Does not affect protein expression, plasma membrane localization, or L-alanine uptake."; /evidence="ECO:0000269|PubMed:34848541"; MUTAGEN 243; /note="F->A: Abolishes leucine and tryptophan transport activities."; /evidence="ECO:0000269|PubMed:33298890"; MUTAGEN 246; /note="G->S: Strong decrease in the uptake of large substrates L-tryptophan, L-glutamine, and L-histidine but increases the uptake of small neutral amino acids glycine and L-alanine."; /evidence="ECO:0000269|PubMed:34848541"; MUTAGEN 395; /note="N->Q: Strongly reduces L-leucine uptake activity. Strongly reduces L-tryptophan uptake activity."; /evidence="ECO:0000269|PubMed:33298890"; MUTAGEN 396; /note="Y->A: Strongly reduces L-leucine uptake activity."; /evidence="ECO:0000269|PubMed:33298890
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
protein_family
L-type amino acid transporter (LAT) (TC 2.A.3.8) family
uniprot
proteins
pubmed
10080183
uniprot
proteins
pubmed
10391915
uniprot
proteins
pubmed
10574970
uniprot
proteins
pubmed
11311135
uniprot
proteins
pubmed
11847106
uniprot
proteins
pubmed
12117417
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12716892
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15081149
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15769744
uniprot
proteins
pubmed
15918515
uniprot
proteins
pubmed
16027961
uniprot
proteins
pubmed
26305885
uniprot
proteins
pubmed
29355479
uniprot
proteins
pubmed
33066406
uniprot
proteins
pubmed
33298890
uniprot
proteins
pubmed
34848541
uniprot
proteins
pubmed
38661522
uniprot
proteins
sequence_length
535
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29355479, ECO:0000269|PubMed:34848541}; Multi-pass membrane protein {ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:34848541}. Basolateral cell membrane {ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:15918515}; Multi-pass membrane protein {ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:34848541}. Note=Localized to the cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi. {ECO:0000269|PubMed:10574970}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..65; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:33298890, ECO:0007744|PDB:7CMH"; TRANSMEM 74..95; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:33298890, ECO:0007744|PDB:7CMH"; TRANSMEM 117..149; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:33298890, ECO:0007744|PDB:7CMH"; TRANSMEM 158..178; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:33298890, ECO:0007744|PDB:7CMH"; TRANSMEM 182..210; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:33298890, ECO:0007744|PDB:7CMH"; TRANSMEM 231..252; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:33298890, ECO:0007744|PDB:7CMH"; TRANSMEM 266..287; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:33298890, ECO:0007744|PDB:7CMH"; TRANSMEM 313..338; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:33298890, ECO:0007744|PDB:7CMH"; TRANSMEM 365..382; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:33298890, ECO:0007744|PDB:7CMH"; TRANSMEM 387..408; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:33298890, ECO:0007744|PDB:7CMH"; TRANSMEM 424..446; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:33298890, ECO:0007744|PDB:7CMH"; TRANSMEM 447..466; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:33298890, ECO:0007744|PDB:7CMH
uniprot
proteins