Fst
entrez
14313
canonical
uniprot
P47931
canonical
ensembl
ENSMUSG00000021765
resolver
ensp
ENSMUSP00000022287
resolver
ensp
ENSMUSP00000153365
resolver
ensp
ENSMUSP00000156375
resolver
ensp
ENSMUSP00000168244
resolver
enst
ENSMUST00000223640
resolver
genesymbol
Fst
resolver
uniprot
A0A286YDD3
resolver
uniprot
A6H6P0
resolver
uniprot
Q8BNY0
resolver
uniprot_entry
A0A286YDD3_MOUSE
resolver
uniprot_entry
FST_MOUSE
resolver
uniprot_entry
Q8BNY0_MOUSE
resolver
uniprot_sec
A6H6P0
resolver
amino_acid_sequence
MVCARHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGRLSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGKCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPSSSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCGGGKKCLWDSKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCNSISEETEEEEEEEDQDYSFPISSILEW
uniprot
proteins
function
FUNCTION: Multifunctional regulatory protein whose primary function is to antagonize members of the transforming growth factor beta (TGF-beta) superfamily including activin, myostatin, GDF11 or bone morphogenetic proteins (BMPs) (PubMed:7885475, PubMed:20810712). Mechanistically, binds to these ligands in the extracellular space, blocking their type II receptor-binding site to inhibit downstream signaling (By similarity). Plays an essential role in muscle fiber formation and growth both by preventing the repressive effects of myostatin and through SMAD3/AKT/mTOR signaling independently of myostatin (PubMed:22711699, PubMed:20810712). Also promotes neural differentiation by antagonizing the action BMP4 (PubMed:9178255). Acts as a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) by sequestering activin A/INHBA. On the other hand, translocates into the nucleus where it down-regulates rRNA synthesis and ribosome biogenesis to maintain cellular energy homeostasis by binding to rDNA (By similarity). {ECO:0000250|UniProtKB:P19883, ECO:0000269|PubMed:20810712, ECO:0000269|PubMed:22711699, ECO:0000269|PubMed:7885475, ECO:0000269|PubMed:9178255}.
uniprot
proteins
mass_dalton
37866
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20810712
uniprot
proteins
pubmed
22711699
uniprot
proteins
pubmed
27182554
uniprot
proteins
pubmed
7600958
uniprot
proteins
pubmed
7885475
uniprot
proteins
pubmed
7956942
uniprot
proteins
pubmed
9178255
uniprot
proteins
sequence_length
344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P19883}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P19883}.
uniprot
proteins