Epm2a
entrez
114005
canonical
uniprot
Q91XQ2
canonical
ensembl
ENSRNOG00000040242
resolver
ensembl
ENSRNOG00055001787
resolver
ensembl
ENSRNOG00060004833
resolver
ensembl
ENSRNOG00065025151
resolver
ensp
ENSRNOP00000076978
resolver
ensp
ENSRNOP00055002176
resolver
ensp
ENSRNOP00060006018
resolver
ensp
ENSRNOP00065035469
resolver
enst
ENSRNOT00000099572
resolver
enst
ENSRNOT00055002894
resolver
enst
ENSRNOT00060008042
resolver
enst
ENSRNOT00065043273
resolver
genesymbol
Epm2a
resolver
uniprot
F1LPW7
resolver
uniprot_entry
EPM2A_RAT
resolver
uniprot_sec
F1LPW7
resolver
amino_acid_sequence
MLFRFGVVVPPAVAGTRLELLLAGSRPELGRWEPRGAVRLRPAGTAAGAAALALQEPGLWLAEVELAPEEEAADGAEPGRIDTFWYKFLQREPGGELHWEGNGPHHDRCCTYNENNLVDGVYCLPVGHWIEATGHTNEMKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQLEHVTIKLKHELGITAVMNFQTEWDIIQNSSGCNRYPEPMTPDTMMKLYKEEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLENGHTVYVHCNAGVGRSTAAVCGWLHYVIGWSLRKVQYFIMAKRPAVYIDEEALAQAQQDFFQKFGKVHSSICTL
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro). Has also been shown to dephosphorylate MAPT. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates. Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. {ECO:0000250|UniProtKB:O95278, ECO:0000250|UniProtKB:Q9WUA5}.
uniprot
proteins
mass_dalton
37144
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated by NHLRC1/malin. {ECO:0000250|UniProtKB:O95278}.; PTM: Phosphorylation on Ser-25 by AMPK affects the phosphatase activity of the enzyme and its ability to homodimerize and interact with NHLRC1, PPP1R3C or PRKAA2. {ECO:0000250|UniProtKB:O95278}.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
11355878
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O95278}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O95278}; Peripheral membrane protein {ECO:0000250|UniProtKB:O95278}; Cytoplasmic side {ECO:0000250|UniProtKB:O95278}. Cell membrane {ECO:0000250|UniProtKB:O95278}. Note=Colocalizes with glycogen synthase in punctate structures in the cytoplasm. Primarily associated with polyribosomes at the rough endoplasmic reticulum, and also detected at the plasma membrane. Under glycogenolytic conditions localizes to the nucleus. {ECO:0000250|UniProtKB:O95278}.
uniprot
proteins