Rab39b
entrez
67790
canonical
uniprot
Q8BHC1
canonical
ensembl
ENSMUSG00000031202
resolver
ensp
ENSMUSP00000033545
resolver
enst
ENSMUST00000033545
resolver
genesymbol
Rab39b
resolver
genesymbol_syn
Rab39B
resolver
uniprot
Q0PD14
resolver
uniprot
Q3TUJ3
resolver
uniprot_entry
Q0PD14_MOUSE
resolver
uniprot_entry
RB39B_MOUSE
resolver
uniprot_sec
Q3TUJ3
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including C9orf72-SMCR8 complex, which promote the exchange of bound GDP for free GTP (By similarity). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000250|UniProtKB:Q96DA2, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MEAIWLYQFRLIVIGDSTVGKSCLIRRFTEGRFAQVSDPTVGVDFFSRLVEIEPGKRIKLQIWDTAGQERFRSITRAYYRNSVGGLLLFDITNRRSFQNVHEWLEETKVHVQPYQIVFVLVGHKCDLDTQRQVTRHEAEKLAAAYGMKYIETSARDAINVEKAFTDLTRDIYELVKRGEITIQEGWEGVKSGFVPNVVHSSEEVIKSERRCLC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20159109, PubMed:25784538). RAB39B is involved in autophagy and may function in autophagosome formation (By similarity). Binds downstream effector PICK1 to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR composition at the post-synapses and thus synaptic transmission (PubMed:25784538). May regulate the homeostasis of SNCA/alpha-synuclein (PubMed:25434005). {ECO:0000250|UniProtKB:Q96DA2, ECO:0000269|PubMed:20159109, ECO:0000269|PubMed:25434005, ECO:0000269|PubMed:25784538}.
uniprot
proteins
mass_dalton
24636
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20159109
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23294242
uniprot
proteins
pubmed
23624502
uniprot
proteins
pubmed
25434005
uniprot
proteins
pubmed
25784538
uniprot
proteins
pubmed
31651360
uniprot
proteins
sequence_length
213
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96DA2}; Lipid-anchor {ECO:0000250|UniProtKB:Q96DA2}; Cytoplasmic side {ECO:0000250|UniProtKB:Q96DA2}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q96DA2}; Lipid-anchor {ECO:0000250|UniProtKB:Q96DA2}; Cytoplasmic side {ECO:0000250|UniProtKB:Q96DA2}. Golgi apparatus {ECO:0000269|PubMed:20159109}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q96DA2}. Autolysosome membrane {ECO:0000250|UniProtKB:Q96DA2}. Note=Partial colocalization with markers that cycle from the cell surface to the trans-Golgi network. Colocalized with STX17 in autolysosomes in autophagy-induced conditions, although less compared with RAB39A (By similarity). {ECO:0000250|UniProtKB:Q96DA2, ECO:0000269|PubMed:20159109}.
uniprot
proteins