Slco1c1
entrez
84511
canonical
uniprot
Q9EPZ7
canonical
ensembl
ENSRNOG00000009740
resolver
ensp
ENSRNOP00000013230
resolver
enst
ENSRNOT00000013230
resolver
genesymbol
Slco1c1
resolver
genesymbol_syn
Bsat1
resolver
genesymbol_syn
Oatp1c1
resolver
genesymbol_syn
Oatpf
resolver
genesymbol_syn
Slc21a14
resolver
uniprot
G3V795
resolver
uniprot_entry
G3V795_RAT
resolver
uniprot_entry
SO1C1_RAT
resolver
amino_acid_sequence
MDTSSKENAHLFHKNSAQPAGGPSFKAGYPSTEEARPCCGKLKVFLGALSFVYFAKALTEGYLKSTITQIERRFDIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGFGTMLIAVPQFFMEKYSYEKYERYSPSSNLTPNISPCYLESSSPSPRSIVGKSQNKINDECEVDTSSSMWVYVFLGNLLRGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGFLSLLAAVPFWCLPKTLPRSQSREDSGSSSEKSKFITDDPVNYQMAPREESMKIMEMARDFLPSLKSLFRNPVYILYLCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLLFLSLFALGCENSSVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYASACLAGCQSSSRSGKNIIFSNCTCVGFAAPKSGNWSGMMGRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRCIQPQLKSFALGIYTLAVRVLAGIPAPVYFGVLIDTSCLKWGFKKCGSRGSCRLYDSHAFRHIYLGLTTLLGTVSVFLSTAVLLVLKKKYVSKRSSFITAREKIVMSSSVKKETCAARDHGLQPKYWPGKETRL
uniprot
proteins
function
FUNCTION: Mediates the Na(+)-independent high affinity transport of thyroid hormones at the plasma membrane of brain capillary endothelial cells (PubMed:12923172, PubMed:17667996, PubMed:19819953). The transport activity of substrates L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) is much greater than that of 3,3',5-triiodo-L-thyronine (T3) (PubMed:12923172, PubMed:17667996, PubMed:19819953). The prehormone, T4, is the major form in the circulating blood and is converted to the active form, T3, by the iodothyronine-deiodinase in peripheral organs (PubMed:12923172). T3 plays an essential role in brain development via binding to specific nuclear receptors (thyroid hormone receptor) (PubMed:12923172). Also transports organic anions such as the conjugated steroid 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)) (PubMed:12923172, PubMed:17667996, PubMed:19819953). Transports T4 and estrone-3-sulfate in a pH-insensitive manner (By similarity). May serve as a drug efflux system at the blood brain barrier (PubMed:12923172, PubMed:17667996). {ECO:0000250|UniProtKB:Q9NYB5, ECO:0000269|PubMed:12923172, ECO:0000269|PubMed:17667996, ECO:0000269|PubMed:19819953, ECO:0000303|PubMed:12923172}.
uniprot
proteins
mass_dalton
78627
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
11149669
uniprot
proteins
pubmed
12923172
uniprot
proteins
pubmed
17667996
uniprot
proteins
pubmed
18687783
uniprot
proteins
pubmed
19819953
uniprot
proteins
sequence_length
716
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12923172, ECO:0000269|PubMed:18687783}; Multi-pass membrane protein {ECO:0000269|PubMed:18687783}. Note=Expressed in the plasma membranes of brain capillary endothelial cells. {ECO:0000269|PubMed:12923172}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..63; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 83..103; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 110..134; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 188..216; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 236..256; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 275..299; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 353..374; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 395..418; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 423..446; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 559..581; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 591..616; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 651..668; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q9NYB5
uniprot
proteins