DLC1
entrez
10395
canonical
uniprot
Q96QB1
canonical
ensembl
ENSG00000164741
resolver
ensp
ENSP00000276297
resolver
ensp
ENSP00000351797
resolver
ensp
ENSP00000422595
resolver
ensp
ENSP00000425878
resolver
ensp
ENSP00000428028
resolver
ensp
ENSP00000645117
resolver
genesymbol
DLC1
resolver
genesymbol_syn
ARHGAP7
resolver
genesymbol_syn
KIAA1723
resolver
genesymbol_syn
STARD12
resolver
hgnc
HGNC:2897
resolver
uniprot
A8K119
resolver
uniprot
B4DR10
resolver
uniprot
B8PTI0
resolver
uniprot
E9PDZ8
resolver
uniprot
E9PF76
resolver
uniprot
E9PGY9
resolver
uniprot
O14868
resolver
uniprot
O43199
resolver
uniprot
Q7Z5R8
resolver
uniprot
Q86UC6
resolver
uniprot
Q9C0E0
resolver
uniprot
Q9H7A2
resolver
uniprot_entry
A8K119_HUMAN
resolver
uniprot_entry
RHG07_HUMAN
resolver
uniprot_sec
B4DR10
resolver
uniprot_sec
B8PTI0
resolver
uniprot_sec
E9PDZ8
resolver
uniprot_sec
E9PF76
resolver
uniprot_sec
E9PGY9
resolver
uniprot_sec
O14868
resolver
uniprot_sec
O43199
resolver
uniprot_sec
Q7Z5R8
resolver
uniprot_sec
Q86UC6
resolver
uniprot_sec
Q9C0E0
resolver
uniprot_sec
Q9H7A2
resolver
amino_acid_sequence
MSVAIRKRSWEEHVTHWMGQPFNSDDRNTACHHGLVADSLQASMEKDATLNVDRKEKCVSLPDCCHGSELRDFPGRPMGHLSKDVDENDSHEGEDQFLSLEASTETLVHVSDEDNNADLCLTDDKQVLNTQGQKTSGQHMIQGAGSLEKALPIIQSNQVSSNSWGIAGETELALVKESGERKVTDSISKSLELCNEISLSEIKDAPKVNAVDTLNVKDIAPEKQLLNSAVIAQQRRKPDPPKDENERSTCNVVQNEFLDTPCTNRGLPLLKTDFGSCLLQPPSCPNGMSAENGLEKSGFSQHQNKSPPKVKAEDGMQCLQLKETLATQEPTDNQVRLRKRKEIREDRDRARLDSMVLLIMKLDQLDQDIENALSTSSSPSGTPTNLRRHVPDLESGSESGADTISVNQTRVNLSSDTESTDLPSSTPVANSGTKPKTTAIQGISEKEKAEIEAKEACDWLRATGFPQYAQLYEDFLFPIDISLVKREHDFLDRDAIEALCRRLNTLNKCAVMKLEISPHRKRSDDSDEDEPCAISGKWTFQRDSKRWSRLEEFDVFSPKQDLVPGSPDDSHPKDGPSPGGTLMDLSERQEVSSVRSLSSTGSLPSHAPPSEDAATPRTNSVISVCSSSNLAGNDDSFGSLPSPKELSSFSFSMKGHEKTAKSKTRSLLKRMESLKLKSSHHSKHKAPSKLGLIISGPILQEGMDEEKLKQLNCVEISALNGNRINVPMVRKRSVSNSTQTSSSSSQSETSSAVSTPSPVTRTRSLSACNKRVGMYLEGFDPFNQSTFNNVVEQNFKNRESYPEDTVFYIPEDHKPGTFPKALTNGSFSPSGNNGSVNWRTGSFHGPGHISLRRENSSDSPKELKRRNSSSSMSSRLSIYDNVPGSILYSSSGDLADLENEDIFPELDDILYHVKGMQRIVNQWSEKFSDEGDSDSALDSVSPCPSSPKQIHLDVDNDRTTPSDLDSTGNSLNEPEEPSEIPERRDSGVGASLTRSNRHRLRWHSFQSSHRPSLNSVSLQINCQSVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYKDRSVFGVPLTVNVQRTGQPLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNEGAIDCVNYEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAPSLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAECKKLFQVPEEMSRCRNSYTEQELKPLTLEALGHLGNDDSADYQHFLQDCVDGLFKEVKEKFKGWVSYSTSEQAELSYKKVSEGPPLRLWRSVIEVPAVPEEILKRLLKEQHLWDVDLLDSKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNLPKGACALLLTSVDHDRAPVVGVRVNVLLSRYLIEPCGPGKSKLTYMCRVDLRGHMPEWYTKSFGHLCAAEVVKIRDSFSNQNTETKDTKSR
uniprot
proteins
function
FUNCTION: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}.
uniprot
proteins
mass_dalton
170591
uniprot
proteins
mutagenesis
MUTAGEN 475; /note="F->G: Abolishes interaction with EF1A1."; /evidence="ECO:0000269|PubMed:19158340"; MUTAGEN 476; /note="L->G: Abolishes interaction with EF1A1."; /evidence="ECO:0000269|PubMed:19158340"; MUTAGEN 877; /note="S->A: Abolishes interaction with TNS4 and results in diffuse cytoplasmic localization."; /evidence="ECO:0000269|PubMed:17190795"; MUTAGEN 879; /note="Y->F: Unable to displace endogenous DLC1 from focal adhesions. Abolishes interaction with TNS4 and results in diffuse cytoplasmic localization."; /evidence="ECO:0000269|PubMed:17190795, ECO:0000269|PubMed:18786931"; MUTAGEN 1114; /note="R->E: No catalytic activity."; /evidence="ECO:0000269|PubMed:19158340
uniprot
proteins
pubmed
10649492
uniprot
proteins
pubmed
11214970
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17190795
uniprot
proteins
pubmed
18786931
uniprot
proteins
pubmed
19158340
uniprot
proteins
pubmed
19170769
uniprot
proteins
pubmed
19317456
uniprot
proteins
pubmed
19710422
uniprot
proteins
pubmed
19826001
uniprot
proteins
pubmed
20798394
uniprot
proteins
pubmed
21217778
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26166433
uniprot
proteins
pubmed
26427649
uniprot
proteins
pubmed
9605766
uniprot
proteins
sequence_length
1528
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion {ECO:0000269|PubMed:17190795}. Membrane; Peripheral membrane protein. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery.
uniprot
proteins