Tulp3
entrez
22158
canonical
uniprot
O88413
canonical
ensembl
ENSMUSG00000001521
resolver
ensp
ENSMUSP00000001562
resolver
enst
ENSMUST00000001562
resolver
genesymbol
Tulp3
resolver
uniprot_entry
TULP3_MOUSE
resolver
amino_acid_sequence
MEAARCAPGPRGDSAFDDETLRLRQLKLDNQRALLEKKQRKKRLEPLMVQPNPEARLRRLKPRGSEEHTPLVDPQMPRSDVILHGIDGPAAFLKPEAQDLESKPQVLSVGSPAPEEGTEGSADGESPEETAPKPDLQEILQKHGILSSVNYDEEPDKEEDEGGNLSSPSARSEESAAASQKAASETGASGVTAQQGDAQLGEVENLEDFAYSPAPRGVTVKCKVTRDKKGMDRGLFPTYYMHLEREENRKIFLLAGRKRKKSKTSNYLVSTDPTDLSREGESYIGKLRSNLMGTKFTVYDHGVNPVKAQGLVEKAHTRQELAAICYETNVLGFKGPRKMSVIIPGMNMNHERIPFRPRNEHESLLSKWQNKSMENLIELHNKAPVWNDDTQSYVLNFHGRVTQASVKNFQIVHGNDPDYIVMQFGRVADDVFTLDYNYPLCALQAFAIGLSSFDSKLACE
uniprot
proteins
function
FUNCTION: Protein-protein adapter that drives transport of G protein-coupled receptors into primary cilia by mediating association between the intraflagellar transport complex A (IFT-A) and G protein-coupled receptors FFAR4, GPR45 and GPR161 (PubMed:19286674, PubMed:19334287, PubMed:31761534, PubMed:34346313, PubMed:40472089). Acts as a negative regulator of the Shh signaling by promoting trafficking of GPR161 to cilia (PubMed:19223390, PubMed:19286674, PubMed:19334287, PubMed:34346313). During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes (PubMed:31761534). Promotes transport of GPR45 into primary cilia of neurons in paraventricular nucleus (PVN) of the hypothalamus (PubMed:40472089). Binds to phosphorylated inositide (phosphoinositide) lipids; both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking (By similarity). Besides its role in cilium localization, acts as a regulator of AMP-activated protein kinase (AMPK) activity in response to calorie restriction: binds lithocholic acid, a metabolite generated in response to calorie restriction, promoting TULP3 ability to activate SIRT1, which then deacetylates the ATP6V1E1 subunit of the V-ATPase complex, leading to (1) V-ATPase complex inhibition on lysosomes and (2) AMPK activation via the AXIN1-STK11/LKB1 axis (PubMed:39695235). {ECO:0000250|UniProtKB:O75386, ECO:0000269|PubMed:19223390, ECO:0000269|PubMed:19286674, ECO:0000269|PubMed:19334287, ECO:0000269|PubMed:31761534, ECO:0000269|PubMed:34346313, ECO:0000269|PubMed:39695235, ECO:0000269|PubMed:40472089}.
uniprot
proteins
mass_dalton
51231
uniprot
proteins
protein_family
TUB family
uniprot
proteins
pubmed
11406614
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19223390
uniprot
proteins
pubmed
19286674
uniprot
proteins
pubmed
19334287
uniprot
proteins
pubmed
19695251
uniprot
proteins
pubmed
21209331
uniprot
proteins
pubmed
31761534
uniprot
proteins
pubmed
34346313
uniprot
proteins
pubmed
39695235
uniprot
proteins
pubmed
40472089
uniprot
proteins
pubmed
9828123
uniprot
proteins
sequence_length
460
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:19286674, ECO:0000269|PubMed:21209331}. Cell membrane {ECO:0000250|UniProtKB:O75386}. Nucleus {ECO:0000250|UniProtKB:O75386}. Cytoplasm {ECO:0000250|UniProtKB:O75386}. Secreted {ECO:0000269|PubMed:19695251}. Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (PubMed:19695251). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha (By similarity). {ECO:0000250|UniProtKB:O75386, ECO:0000269|PubMed:19695251}.
uniprot
proteins