ARHGEF4
entrez
50649
canonical
uniprot
Q9NR80
canonical
ensembl
ENSG00000136002
resolver
ensp
ENSP00000316845
resolver
ensp
ENSP00000386794
resolver
ensp
ENSP00000387285
resolver
ensp
ENSP00000736589
resolver
enst
ENST00000409359
resolver
genesymbol
ARHGEF4
resolver
genesymbol_syn
KIAA1112
resolver
hgnc
HGNC:684
resolver
uniprot
E7EV07
resolver
uniprot
Q9HDC6
resolver
uniprot
Q9UPP0
resolver
uniprot_entry
ARHG4_HUMAN
resolver
uniprot_entry
E7EV07_HUMAN
resolver
uniprot_sec
Q9HDC6
resolver
uniprot_sec
Q9UPP0
resolver
amino_acid_sequence
MPWEEPAGEKPSCSHSQKAFHMEPAQKPCFTTDMVTWALLCISAETVRGEAPSQPRGIPHRSPVSVDDLWLEKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSHPLSQSAPTGLNHMGWPEHTPGTAMPDGALDTAVCADEVGSEEDLYDDLHSSSHHYSHPGGGGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKAVGRPCYLTRQKHPALPSNRPQQQVLVLAEPRRKPSTFWHSISRLAPFRK
uniprot
proteins
function
FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:12598901, ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19893577}.
uniprot
proteins
mass_dalton
79067
uniprot
proteins
pubmed
10470851
uniprot
proteins
pubmed
10873612
uniprot
proteins
pubmed
10947987
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12598901
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17145773
uniprot
proteins
pubmed
17190834
uniprot
proteins
pubmed
17599059
uniprot
proteins
pubmed
19893577
uniprot
proteins
sequence_length
690
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Associated with membrane ruffles. {ECO:0000305}.
uniprot
proteins