SIKE1
entrez
80143
canonical
uniprot
Q9BRV8
canonical
ensembl
ENSG00000052723
resolver
ensp
ENSP00000060969
resolver
ensp
ENSP00000358541
resolver
genesymbol
SIKE1
resolver
genesymbol_syn
SIKE
resolver
hgnc
HGNC:26119
resolver
uniprot
Q5TEZ7
resolver
uniprot
Q5TEZ9
resolver
uniprot
Q68DZ4
resolver
uniprot
Q9H778
resolver
uniprot_entry
SIKE1_HUMAN
resolver
uniprot_sec
Q5TEZ7
resolver
uniprot_sec
Q5TEZ9
resolver
uniprot_sec
Q68DZ4
resolver
uniprot_sec
Q9H778
resolver
amino_acid_sequence
MSCTIEKILTDAKTLLERLREHDAAAESLVDQSAALHRRVAAMREAGTALPDQYQEDASDMKDMSKYKPHILLSQENTQIRDLQQENRELWISLEEHQDALELIMSKYRKQMLQLMVAKKAVDAEPVLKAHQSHSAEIESQIDRICEMGEVMRKAVQVDDDQFCKIQEKLAQLELENKELRELLSISSESLQARKENSMDTASQAIK
uniprot
proteins
function
FUNCTION: Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways (PubMed:16281057). Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:30622739). {ECO:0000269|PubMed:16281057, ECO:0000269|PubMed:30622739}.
uniprot
proteins
mass_dalton
23721
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="L->D: Loss of interaction with SLMAP."; /evidence="ECO:0000269|PubMed:30622739"; MUTAGEN 19; /note="L->D: Loss of interaction with SLMAP."; /evidence="ECO:0000269|PubMed:30622739"; MUTAGEN 36; /note="L->D: Loss of interaction with SLMAP."; /evidence="ECO:0000269|PubMed:30622739"; MUTAGEN 43; /note="M->E: No effect on interaction with SLMAP."; /evidence="ECO:0000269|PubMed:30622739"; MUTAGEN 90; /note="L->D: Loss of (SIKE1:SLMAP)STRIPAK complex formation."; /evidence="ECO:0000269|PubMed:30622739"; MUTAGEN 94; /note="L->D: Loss of (SIKE1:SLMAP)STRIPAK complex formation."; /evidence="ECO:0000269|PubMed:30622739"; MUTAGEN 96; /note="E->A: Loss of (SIKE1:SLMAP)STRIPAK complex formation; when associated with A-109."; /evidence="ECO:0000269|PubMed:30622739"; MUTAGEN 97; /note="H->D: Loss of (SIKE1:SLMAP)STRIPAK complex formation."; /evidence="ECO:0000269|PubMed:30622739"; MUTAGEN 101; /note="L->D: Loss of (SIKE1:SLMAP)STRIPAK complex formation."; /evidence="ECO:0000269|PubMed:30622739"; MUTAGEN 109; /note="R->A: Loss of (SIKE1:SLMAP)STRIPAK complex formation; when associated with A-109."; /evidence="ECO:0000269|PubMed:30622739
uniprot
proteins
protein_family
SIKE family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16281057
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
25743393
uniprot
proteins
pubmed
30622739
uniprot
proteins
sequence_length
207
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16281057}.
uniprot
proteins