Cd37
entrez
29185
canonical
uniprot
P31053
canonical
ensembl
ENSRNOG00000020699
resolver
ensp
ENSRNOP00000077102
resolver
ensp
ENSRNOP00000101719
resolver
ensp
ENSRNOP00000107676
resolver
enst
ENSRNOT00000136795
resolver
genesymbol
Cd37
resolver
uniprot
A0ABK0LES7
resolver
uniprot_entry
A0ABK0LES7_RAT
resolver
uniprot_entry
CD37_RAT
resolver
amino_acid_sequence
MSAQESCLSLIKYFLFVFNLFFFVLGGLIFCFGTWILIDKTSFVSFVGLSFVPLQTWSKVLSVSGVLTMALALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRVRLERRVQELVLRTIQSYRTNPDETAAEESWDYAQFQLRCCGWQSPRDWNKAQMLKANGSEELFVPCSCYNSTATNDSSGFDKLFLSQLSRLGPRAKLRQTADICALPAKAHIYREGCARSLQKWLHNNIISIVGICLGVGLLELGFMTLSIFLCRNLDHVYDRLARYR
uniprot
proteins
function
FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B (By similarity). Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT (By similarity). Plays also a role in the migration of dendritic cells and neutrophils to draining lymph nodes, as well as in their integrin-mediated adhesion (By similarity). Negatively regulates IL-6 responses through direct interaction with SOCS3 thereby preventing constitutive IL-6 signaling. Alternatively, inhibition of IL-6 signaling can also occur via interaction and stabilization of DECTIN1/CLEC7A at the cell membrane to inhibit its ability to promote the production of IL-6 (By similarity). {ECO:0000250|UniProtKB:P11049, ECO:0000250|UniProtKB:Q61451}.
uniprot
proteins
mass_dalton
31750
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated; leading to activation of downstream signaling pathways. {ECO:0000250|UniProtKB:P11049}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2388030
uniprot
proteins
pubmed
2466944
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P11049}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P11049}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 60..74; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 86..111; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 242..266; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins