Plaur
entrez
18793
canonical
uniprot
P35456
canonical
ensembl
ENSMUSG00000046223
resolver
ensp
ENSMUSP00000002284
resolver
ensp
ENSMUSP00000196263
resolver
genesymbol
Plaur
resolver
uniprot
P35457
resolver
uniprot
Q545X5
resolver
uniprot_entry
Q545X5_MOUSE
resolver
uniprot_entry
UPAR_MOUSE
resolver
uniprot_sec
P35457
resolver
activity_regulation
ACTIVITY REGULATION: Cleavage of the GPI anchor by GDPD2 inactivates receptor functions in vitronectin-mediated cell-matrix adhesion and plasmin-dependent extracellular matrix remodeling. {ECO:0000250|UniProtKB:Q03405}.
uniprot
proteins
amino_acid_sequence
MGLPRRLLLLLLLATTCVPASQGLQCMQCESNQSCLVEECALGQDLCRTTVLREWQDDRELEVVTRGCAHSEKTNRTMSYRMGSMIISLTETVCATNLCNRPRPGARGRAFPQGRYLECASCTSLDQSCERGREQSLQCRYPTEHCIEVVTLQSTERSLKDEDYTRGCGSLPGCPGTAGFHSNQTFHFLKCCNYTHCNGGPVLDLQSFPPNGFQCYSCEGNNTLGCSSEEASLINCRGPMNQCLVATGLDVLGNRSYTVRGCATASWCQGSHVADSFPTHLNVSVSCCHGSGCNSPTGGAPRPGPAQLSLIASLLLTLGLWGVLLWT
uniprot
proteins
function
FUNCTION: GPI-anchored receptor that recruits and activates the urokinase-type plasminogen activator (uPA) at the cell surface. Activated uPA converts plasminogen into plasmin, initiating extracellular matrix degradation and remodeling. Also binds the extracellular matrix protein vitronectin, promoting cell-matrix adhesion and indirectly integrin signaling. This dual interaction coordinates dynamic changes in cell migration, proliferation, and tissue remodeling. {ECO:0000250|UniProtKB:Q03405}.
uniprot
proteins
mass_dalton
35428
uniprot
proteins
post_translational_modification
PTM: Attached to the external leaflet of the plasma membrane via a GPI anchor. The GPI anchor can be cleaved by a phospholipase, releasing the protein from membranes. {ECO:0000250|UniProtKB:Q03405}.
uniprot
proteins
pubmed
1661735
uniprot
proteins
pubmed
19667118
uniprot
proteins
pubmed
20133942
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7929309
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:Q03405}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q03405}. Cell projection, invadopodium membrane {ECO:0000250|UniProtKB:Q03405}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q03405}. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. {ECO:0000250|UniProtKB:Q03405}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000250|UniProtKB:P49616}.
uniprot
proteins