PLEKHA8
entrez
84725
canonical
uniprot
Q96JA3
canonical
ensembl
ENSG00000106086
resolver
ensp
ENSP00000258679
resolver
ensp
ENSP00000379556
resolver
ensp
ENSP00000379558
resolver
ensp
ENSP00000397947
resolver
ensp
ENSP00000484427
resolver
ensp
ENSP00000760861
resolver
ensp
ENSP00000789111
resolver
ensp
ENSP00000789112
resolver
enst
ENST00000396259
resolver
enst
ENST00000622102
resolver
genesymbol
PLEKHA8
resolver
genesymbol_syn
FAPP2
resolver
hgnc
HGNC:30037
resolver
uniprot
A0A087X1S6
resolver
uniprot
A0A2P1JJM6
resolver
uniprot
B4DH00
resolver
uniprot
B5MDU3
resolver
uniprot
Q7Z5V8
resolver
uniprot
Q9BU78
resolver
uniprot
Q9H274
resolver
uniprot
Q9H8Z7
resolver
uniprot_entry
A0A087X1S6_HUMAN
resolver
uniprot_entry
A0A2P1JJM6_HUMAN
resolver
uniprot_entry
B5MDU3_HUMAN
resolver
uniprot_entry
PKHA8_HUMAN
resolver
uniprot_sec
B4DH00
resolver
uniprot_sec
Q7Z5V8
resolver
uniprot_sec
Q9BU78
resolver
uniprot_sec
Q9H274
resolver
uniprot_sec
Q9H8Z7
resolver
amino_acid_sequence
MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSELRLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSELLYRTPPGSPQLAMLKSSKMKHPIIPIHNSLERQMELSTCENGSLNMEINGEEEILMKNKNSLYLKSAEIDCSISSEENTDDNITVQGEIRKEDGMENLKNHDNNLTQSGSDSSCSPECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLKGFLTEVKNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAALTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV
uniprot
proteins
function
FUNCTION: Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane, playing a pivotal role in the synthesis of complex glycosphingolipids; binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for this GlcCer transfer ability (PubMed:15107860, PubMed:16103222, PubMed:17687330). Also functions as a cargo transport protein required for apical transport from the Golgi complex, including transport of AQP2 from the TGN to sites of AQP2 phosphorylation. Additionally required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity). {ECO:0000250|UniProtKB:D2KC46, ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:16103222, ECO:0000269|PubMed:17687330}.
uniprot
proteins
mass_dalton
58261
uniprot
proteins
mutagenesis
MUTAGEN 18; /note="R->L: Abolishes binding to phosphatylinositol 4-phosphate, less association with Golgi and no preference for TGN location."; /evidence="ECO:0000269|PubMed:17687330"; MUTAGEN 367; /note="K->S: Impairs transfer of glycosphingolipids."; /evidence="ECO:0000269|PubMed:30206120"; MUTAGEN 403; /note="E->L: Impairs transfer of glycosphingolipids."; /evidence="ECO:0000269|PubMed:30206120"; MUTAGEN 407; /note="W->A: Loss of glucosylceramide transfer activity from the TGN to the plasma membrane."; /evidence="ECO:0000269|PubMed:17687330
uniprot
proteins
pubmed
11001876
uniprot
proteins
pubmed
12747765
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15107860
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16103222
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17687330
uniprot
proteins
pubmed
30206120
uniprot
proteins
sequence_length
519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15107860}; Peripheral membrane protein {ECO:0000269|PubMed:15107860}; Cytoplasmic side {ECO:0000269|PubMed:15107860}. Note=Binds through its PH domain to PtdIns(4)P and ARF1, and subsequently localizes to TGN exit sites. {ECO:0000269|PubMed:15107860}.
uniprot
proteins