Kcnu1
entrez
16532
canonical
uniprot
O54982
canonical
ensembl
ENSMUSG00000031576
resolver
ensp
ENSMUSP00000096457
resolver
genesymbol
Kcnu1
resolver
genesymbol_syn
Kcnma3
resolver
genesymbol_syn
Ksper
resolver
genesymbol_syn
Slo3
resolver
uniprot
D3Z5P2
resolver
uniprot
G3X9P7
resolver
uniprot_entry
KCNU1_MOUSE
resolver
uniprot_sec
D3Z5P2
resolver
uniprot_sec
G3X9P7
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by changes in cytosolic pH; activated by alkalization (PubMed:9452476). In contrast to human KCNU1 is not activated by Ca(2+) or Mg(2+) (PubMed:9452476). The auxiliary subunit LRRC52 shifts the activation of KCNU1 to more negative potentials at a given pH (PubMed:22084117). {ECO:0000269|PubMed:22084117, ECO:0000269|PubMed:9452476}.
uniprot
proteins
amino_acid_sequence
MSQTLLDSLNQKELTETSCTIEIQAAFILSSLATFFGGLIILFLFRIALKSSRSWKYVKGPRGLLELFSSRRIEANPLRKLYFHGVFRQRIEMLLSAQTVVGQVLVILVFVLSIGSLVIYFINSMDPVRRCSSYEDKIVHVDLSFNAFFSFYFGLRFWAAEDKIKFWLEMNSIVDIFTIPPTFISYYLKSNWLGLRFLRALRLLELPKILQILQVIKTSNSVKLSKLLSIVISTWFTAAGFLHLVENSGDPWLNGRNSQTMSYFESIYLVTATMSTVGFGDVVAKTSLGRIFIVFFTLGSLILFANYIPEMVELFSTRKKYTKPYEAVKGKKFIVVCGNITVDSVTAFLRNFLHWKSGEINIEIVFLGETLPCLELETLLKCHTSCTNFVCGTALKFEDLKRVAVENSEACLILANHFCSDLHDEDNSNIMRVLSIKNYYPQTRVIIQILQSQNKVFLSKIPNWDWSAGDNILCFAELKLGFIAQGCLVPGLCTFLTTLFIEQNQKVFPKHPWQKHFLNGLKNKILTQRLSNDFVGMTFPQVSRLCFVKLNLMLIAIQHKPFFHSCCTLILNPSSQVRLNKDTLGFFIADSSKAVKRAFFYCSNCHSDVCNPELIGKCNCKIKSRQQLIAPTIMVMKSSLTDFTTSSHIHASMSTEIHTCFSREQPSLITITTNRPTTNDTVDDTDMLDSSGMFHWCRAMPLDKVVLKRSEKAKHEFQNHIVVCVFGDAQCTLVGLRNFVMPLRASNYTRQELKDIVFIGSLEYFQREWRFLRNFPKIHIMPGSALYMGDLIAVNVEQCSMCVILATPYKALSSQILVDTEAIMATLNIQSLRITSPTPGSSKSEVKPSSAFDSKERKQRYKQIPILTELKNPSNIHFIEQMGGLDGMLKGTSLHLSTSFSTGAVFSDTFLDSLLATSFYNYHVVELLQMLVTGGISSEMEHYLVKEKPYKTTDDYEAIKSGRTRCKLGLLSLDQTVLSGINPRKTFGQLFCGSLDNFGILCVGLYRMIDEEEPSQEHKRFVITRPSNECHLLPSDLVFCAIPFNTTCGKSDSSPSIQAQNNSTNATTPLAQGSNFFDSHHADESHDLYPVDDTGERWSQHHHSRVYPLDTLDASDIVQEK
uniprot
proteins
function
FUNCTION: Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+) (PubMed:25675513, PubMed:9452476). Represents the primary spermatozoan K(+) current. The channel underlies a pH-triggered membrane hyperpolarization during the process of sperm capacitation, as sperm encounter the alkaline environment near the ovum in the female reproductive tract, thereby playing an essential for male fertility (PubMed:11696614, PubMed:11723163, PubMed:15201331, PubMed:16940554, PubMed:16940555, PubMed:20138882, PubMed:21427226, PubMed:23129643, PubMed:25675513, PubMed:9452476). {ECO:0000269|PubMed:11696614, ECO:0000269|PubMed:11723163, ECO:0000269|PubMed:15201331, ECO:0000269|PubMed:16940554, ECO:0000269|PubMed:16940555, ECO:0000269|PubMed:20138882, ECO:0000269|PubMed:21427226, ECO:0000269|PubMed:23129643, ECO:0000269|PubMed:25675513, ECO:0000269|PubMed:9452476}.
uniprot
proteins
mass_dalton
126912
uniprot
proteins
mutagenesis
MUTAGEN 279; /note="F->Y: Does not induce any change in single channel conductance or variance in open current levels."; /evidence="ECO:0000269|PubMed:16940554"; MUTAGEN 720; /note="H->R: Homozygous males are infertile. In mutant sperm, the protein is barely detectable by Western blot."; /evidence="ECO:0000269|PubMed:35551387
uniprot
proteins
protein_family
Calcium-activated (TC 1.A.1.3) subfamily
uniprot
proteins
protein_family
KCa5.1/KCNU1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
11696614
uniprot
proteins
pubmed
11723163
uniprot
proteins
pubmed
15201331
uniprot
proteins
pubmed
16940554
uniprot
proteins
pubmed
16940555
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20138882
uniprot
proteins
pubmed
21427226
uniprot
proteins
pubmed
22084117
uniprot
proteins
pubmed
23129643
uniprot
proteins
pubmed
25675513
uniprot
proteins
pubmed
31270758
uniprot
proteins
pubmed
35551387
uniprot
proteins
pubmed
9452476
uniprot
proteins
sequence_length
1121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:22084117}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:31270758}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical; Name=Segment S0"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 138..158; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 166..186; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 227..247; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 291..311; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins