Ptpn5
entrez
19259
canonical
uniprot
P54830
canonical
ensembl
ENSMUSG00000030854
resolver
ensp
ENSMUSP00000033142
resolver
ensp
ENSMUSP00000099686
resolver
ensp
ENSMUSP00000227965
resolver
ensp
ENSMUSP00000227968
resolver
genesymbol
Ptpn5
resolver
uniprot
Q64694
resolver
uniprot
Q80WU9
resolver
uniprot
Q8CAN0
resolver
uniprot_entry
PTN5_MOUSE
resolver
uniprot_entry
Q80WU9_MOUSE
resolver
uniprot_sec
Q64694
resolver
uniprot_sec
Q8CAN0
resolver
amino_acid_sequence
MCCSERLLGLPQPVEMEAPDEAEGLPSKQKEMPPPPPPSPPSEPAQKLPPQGAGSHSLTVRSSLCLFAASQFLLACGVLWLSGHGHSWLQNTTDLISSSLTVLNHLGPVAWLGSGTWGIPSLLLVSLTVSLVIVTTLVWHLLKAPPEPPAPLPPEDRRQSVSRQPSFTYSEWMEEKVEDDFLDLDAVPETPVFDCVMDIKPETDPASLTVKSMGLQERRGSNVSLTLDMCTPGCNEEGFGYLVSPREESAHEYLLSASRVLRAEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVRLTSPDPEDPLSSYINANYIRGYSGEEKVYIATQGPIVSTVADFWRMVWQERTPIIVMITNIEEMNEKCTEYWPEEQVVHDGVEITVQKVIHTEDYRLRLISLRRGTEERSLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCSPIIVHCSAGIGRTGCFIATSICCQQLRREGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHAMSLYEKQLSLQSSE
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. {ECO:0000250}.
uniprot
proteins
mass_dalton
60815
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-221 by PKA deactivates PTPN5. Phosphorylation at Thr-231 and Ser-244 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Non-receptor class subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7494467
uniprot
proteins
pubmed
8987810
uniprot
proteins
sequence_length
541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform STEP61]: Endoplasmic reticulum membrane; Multi-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform STEP46]: Cytoplasm.
uniprot
proteins
transmembrane_region
TRANSMEM 64..84; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 122..142; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins