HACL2
entrez
10994
canonical
uniprot
A1L0T0
canonical
ensembl
ENSG00000105135
resolver
ensp
ENSP00000263383
resolver
ensp
ENSP00000470942
resolver
ensp
ENSP00000533011
resolver
ensp
ENSP00000533018
resolver
enst
ENST00000263383
resolver
enst
ENST00000534378
resolver
enst
ENST00000862952
resolver
enst
ENST00000862959
resolver
genesymbol
HACL2
resolver
genesymbol_syn
AHAS
resolver
genesymbol_syn
ILVBL
resolver
hgnc
HGNC:6041
resolver
uniprot
M0R026
resolver
uniprot
O43341
resolver
uniprot
Q96F08
resolver
uniprot
Q99651
resolver
uniprot
Q9BWN5
resolver
uniprot
Q9UEB2
resolver
uniprot_entry
HACL2_HUMAN
resolver
uniprot_entry
M0R026_HUMAN
resolver
uniprot_sec
O43341
resolver
uniprot_sec
Q96F08
resolver
uniprot_sec
Q99651
resolver
uniprot_sec
Q9BWN5
resolver
uniprot_sec
Q9UEB2
resolver
amino_acid_sequence
METPAAAAPAGSLFPSFLLLACGTLVAALLGAAHRLGLFYQLLHKVDKASVRHGGENVAAVLRAHGVRFIFTLVGGHISPLLVACEKLGIRVVDTRHEVTAVFAADAMARLSGTVGVAAVTAGPGLTNTVTAVKNAQMAQSPILLLGGAASTLLQNRGALQAVDQLSLFRPLCKFCVSVRRVRDIVPTLRAAMAAAQSGTPGPVFVELPVDVLYPYFMVQKEMVPAKPPKGLVGRVVSWYLENYLANLFAGAWEPQPEGPLPLDIPQASPQQVQRCVEILSRAKRPLMVLGSQALLTPTSADKLRAAVETLGVPCFLGGMARGLLGRNHPLHIRENRSAALKKADVIVLAGTVCDFRLSYGRVLSHSSKIIIVNRNREEMLLNSDIFWKPQEAVQGDVGSFVLKLVEGLQGQTWAPDWVEELREADRQKEQTFREKAAMPVAQHLNPVQVLQLVEETLPDNSILVVDGGDFVGTAAHLVQPRGPLRWLDPGAFGTLGVGAGFALGAKLCRPDAEVWCLFGDGAFGYSLIEFDTFVRHKIPVMALVGNDAGWTQISREQVPSLGSNVACGLAYTDYHKAAMGLGARGLLLSRENEDQVVKVLHDAQQQCRDGHPVVVNILIGRTDFRDGSIAV
uniprot
proteins
ec_number
4.1.2.-
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway. {ECO:0000269|PubMed:28289220}.
uniprot
proteins
mass_dalton
67868
uniprot
proteins
protein_family
TPP enzyme family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28289220
uniprot
proteins
pubmed
8954801
uniprot
proteins
sequence_length
632
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:28289220}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins