Styx
entrez
56291
canonical
uniprot
Q60969
canonical
ensembl
ENSMUSG00000053205
resolver
ensembl
ENSMUSG00000071748
resolver
ensp
ENSMUSP00000153854
resolver
ensp
ENSMUSP00000244739
resolver
genesymbol
Styx
resolver
uniprot
Q3TMA3
resolver
uniprot
Q60970
resolver
uniprot
Q9DCF8
resolver
uniprot_entry
STYX_MOUSE
resolver
uniprot_sec
Q3TMA3
resolver
uniprot_sec
Q60970
resolver
uniprot_sec
Q9DCF8
resolver
amino_acid_sequence
MEDVKLEFPSLPQCKDDAEEWTYPMRREMQEVLPGLFLGPYSSAMKSKLPILQKHGITHIICIRQNIEANFIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQNGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIYLAKLTIQMMSPLQIERSLAVHSGTTGSVKRTHEEDDDFGNMQVATAQNG
uniprot
proteins
function
FUNCTION: Catalytically inactive phosphatase (PubMed:7592916). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (By similarity). Plays a role in spermatogenesis (PubMed:11842224). {ECO:0000250|UniProtKB:Q8WUJ0, ECO:0000269|PubMed:11842224, ECO:0000269|PubMed:7592916}.
uniprot
proteins
mass_dalton
25430
uniprot
proteins
mutagenesis
MUTAGEN 120; /note="G->C: Confers phosphatase activity."; /evidence="ECO:0000269|PubMed:7592916
uniprot
proteins
protein_family
Non-receptor class subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
11842224
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7592916
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WUJ0}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8WUJ0}. Note=Predominantly localizes to the nucleus. {ECO:0000250|UniProtKB:Q8WUJ0}.
uniprot
proteins