Stambp
entrez
70527
canonical
uniprot
Q9CQ26
canonical
ensembl
ENSMUSG00000006906
resolver
ensp
ENSMUSP00000070876
resolver
ensp
ENSMUSP00000145871
resolver
ensp
ENSMUSP00000146294
resolver
enst
ENSMUST00000068054
resolver
enst
ENSMUST00000206400
resolver
enst
ENSMUST00000206592
resolver
genesymbol
Stambp
resolver
genesymbol_syn
Amsh
resolver
uniprot
Q3UTI9
resolver
uniprot_entry
STABP_MOUSE
resolver
uniprot_sec
Q3UTI9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethylmaleimide. {ECO:0000250|UniProtKB:O95630}.
uniprot
proteins
amino_acid_sequence
MSDHGDVSLPPQDRVRILSQLGSAVELNEDIPPRRYYRSGVEIIRMASVYSEEGNIEHAFILYNKYITLFIEKLPKHRDYKSAIIPEKKDAVKKLKSVAFPKAEELKTELLRRYTKEYEQYKERKKKEEEELARNIAIQQELEKEKQRVAQQKQKQLEQEQFHAFEEMIQRQELEKERLKIVQEFGKVDPGPCGPLLPDLEKPCVDVAPSSPFSPTQTPDCNTGMRPAKPPVVDRSLKPGALSVIENVPTIEGLRHIVVPRNLCSEFLQLASANTAKGIETCGVLCGKLMRNEFTITHVLIPRQNGGPDYCHTENEEEIFFMQDDLGLLTLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKFQETGFFKLTDYGLQEISTCRQKGFHPHGRDPPLFCDCSHVTVKDRIVTITDLR
uniprot
proteins
ec_number
3.4.19.-
uniprot
proteins
function
FUNCTION: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. {ECO:0000250|UniProtKB:O95630}.
uniprot
proteins
mass_dalton
48514
uniprot
proteins
post_translational_modification
PTM: Phosphorylated after BMP type I receptor activation. {ECO:0000250|UniProtKB:O95630}.; PTM: Ubiquitinated by SMURF2 in the presence of RNF11. {ECO:0000250|UniProtKB:O95630}.
uniprot
proteins
protein_family
Peptidase M67C family
uniprot
proteins
pubmed
11713295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95630}. Membrane {ECO:0000250|UniProtKB:O95630}; Peripheral membrane protein {ECO:0000250|UniProtKB:O95630}. Cytoplasm {ECO:0000250|UniProtKB:O95630}. Early endosome {ECO:0000250|UniProtKB:O95630}.
uniprot
proteins