Efcab9
entrez
69306
canonical
uniprot
Q9DAM2
canonical
ensembl
ENSMUSG00000044056
resolver
ensp
ENSMUSP00000060205
resolver
enst
ENSMUST00000054327
resolver
genesymbol
Efcab9
resolver
uniprot
Q9D5P6
resolver
uniprot_entry
EFCB9_MOUSE
resolver
uniprot_sec
Q9D5P6
resolver
amino_acid_sequence
MKLTPGCFLWYLYMDKIYCLLSLRNVKALMVYFHLLDVHHRNTLNDVLFFHFLQHVTNLNKSQIGMIFDLLDWTAVGEIGFDQFYVLICILLAHQDHLEDHFMYRHSRPVFELLDLDGEMNIGAANFQNYRFLFNIKKQELRDLFHDFDITGDRLLNYKEFKLYTIFCTDKSIDRKKRRKDREAAREREKEKGKDKEKYLHLKKIYSSMLSHRSIL
uniprot
proteins
function
FUNCTION: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation (PubMed:31056283, PubMed:34225353). pH-dependent Ca(2+) sensor required to activate the CatSper channel (PubMed:31056283). Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (PubMed:31056283). Associates with the CatSper complex via direct interaction with CATSPERZ, and senses intracellular Ca(2+) (PubMed:31056283). Together with CATSPERZ, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel (PubMed:31056283). {ECO:0000269|PubMed:31056283, ECO:0000269|PubMed:34225353}.
uniprot
proteins
mass_dalton
26125
uniprot
proteins
mutagenesis
MUTAGEN 72; /note="D->N: Reduced interaction with CATSPERZ due to defects in Ca(2+)-binding; when associated with Q-160."; /evidence="ECO:0000269|PubMed:31056283"; MUTAGEN 160; /note="E->Q: Reduced interaction with CATSPERZ due to defects in Ca(2+)-binding; when associated with N-72."; /evidence="ECO:0000269|PubMed:31056283
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
31056283
uniprot
proteins
pubmed
34225353
uniprot
proteins
sequence_length
216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31056283}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:31056283}. Note=Localizes to the principal piece of the sperm tail. {ECO:0000269|PubMed:31056283}.
uniprot
proteins