NRG2
entrez
9542
canonical
uniprot
O14511
canonical
ensembl
ENSG00000158458
resolver
ensp
ENSP00000289409
resolver
ensp
ENSP00000289422
resolver
ensp
ENSP00000342660
resolver
ensp
ENSP00000351323
resolver
ensp
ENSP00000354910
resolver
ensp
ENSP00000444235
resolver
ensp
ENSP00000721808
resolver
enst
ENST00000541337
resolver
genesymbol
NRG2
resolver
genesymbol_syn
NTAK
resolver
hgnc
HGNC:7998
resolver
uniprot
F5GZS7
resolver
uniprot_entry
F5GZS7_HUMAN
resolver
uniprot_entry
NRG2_HUMAN
resolver
amino_acid_sequence
MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPPRAKQDSAPL
uniprot
proteins
function
FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
uniprot
proteins
mass_dalton
91679
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. {ECO:0000250}.; PTM: Extensive glycosylation precedes the proteolytic cleavage. {ECO:0000250}.
uniprot
proteins
protein_family
Neuregulin family
uniprot
proteins
pubmed
10369162
uniprot
proteins
pubmed
10867024
uniprot
proteins
pubmed
9199335
uniprot
proteins
pubmed
9348101
uniprot
proteins
sequence_length
850
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Pro-neuregulin-2, membrane-bound isoform]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.; SUBCELLULAR LOCATION: [Neuregulin-2]: Secreted {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 406..426; /note="Helical; Note=Internal signal sequence"; /evidence="ECO:0000255
uniprot
proteins