DIS3
entrez
22894
canonical
uniprot
Q9Y2L1
canonical
ensembl
ENSG00000083520
resolver
ensp
ENSP00000366997
resolver
ensp
ENSP00000367011
resolver
ensp
ENSP00000440058
resolver
enst
ENST00000545453
resolver
genesymbol
DIS3
resolver
genesymbol_syn
KIAA1008
resolver
genesymbol_syn
RRP44
resolver
hgnc
HGNC:20604
resolver
uniprot
A6NI21
resolver
uniprot
B2RBL2
resolver
uniprot
G3V1J5
resolver
uniprot
Q5W0P7
resolver
uniprot
Q5W0P8
resolver
uniprot
Q658Z7
resolver
uniprot
Q7Z481
resolver
uniprot
Q8WWI2
resolver
uniprot
Q9UG36
resolver
uniprot_entry
G3V1J5_HUMAN
resolver
uniprot_entry
RRP44_HUMAN
resolver
uniprot_sec
A6NI21
resolver
uniprot_sec
B2RBL2
resolver
uniprot_sec
Q5W0P7
resolver
uniprot_sec
Q5W0P8
resolver
uniprot_sec
Q658Z7
resolver
uniprot_sec
Q7Z481
resolver
uniprot_sec
Q8WWI2
resolver
uniprot_sec
Q9UG36
resolver
amino_acid_sequence
MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIDVLEDPAIRNVIVLQTVLQEVRNRSAPVYKRIRDVTNNQEKHFYTFTNEHHRETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNLEIKTDTAKSLAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADVIVHRLLAVAIGADCTYPELTDKHKLADICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTVFHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLNGPKKKKMKLGK
uniprot
proteins
ec_number
3.1.13.-
uniprot
proteins
ec_number
3.1.26.-
uniprot
proteins
function
FUNCTION: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. {ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20531386}.
uniprot
proteins
mass_dalton
109003
uniprot
proteins
mutagenesis
MUTAGEN 146; /note="D->N: Loss of endonuclease activity; when associated with N-487."; /evidence="ECO:0000269|PubMed:20531386"; MUTAGEN 487; /note="D->N: Loss of exonuclease activity. Loss of endonuclease activity; when associated with N-146."; /evidence="ECO:0000269|PubMed:20531386
uniprot
proteins
protein_family
RNR ribonuclease family
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
11935316
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19056938
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20531386
uniprot
proteins
pubmed
20531389
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25220460
uniprot
proteins
pubmed
29906447
uniprot
proteins
pubmed
30047866
uniprot
proteins
pubmed
9562621
uniprot
proteins
sequence_length
958
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20531386}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Nucleus, nucleoplasm {ECO:0000269|PubMed:20531389}. Nucleus {ECO:0000269|PubMed:20531386}. Note=Predominantly located in the nucleus (PubMed:20531386). According to PubMed:12429849, found in the nucleolus (PubMed:12429849). According to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3 (PubMed:20531386). {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:20531386}.
uniprot
proteins