PRKRA
entrez
8575
canonical
uniprot
O75569
canonical
ensembl
ENSG00000180228
resolver
ensp
ENSP00000318176
resolver
ensp
ENSP00000393883
resolver
ensp
ENSP00000430604
resolver
ensp
ENSP00000502919
resolver
ensp
ENSP00000503011
resolver
ensp
ENSP00000504030
resolver
ensp
ENSP00000504507
resolver
enst
ENST00000677460
resolver
enst
ENST00000677689
resolver
enst
ENST00000678775
resolver
enst
ENST00000678845
resolver
genesymbol
PRKRA
resolver
genesymbol_syn
PACT
resolver
genesymbol_syn
RAX
resolver
hgnc
HGNC:9438
resolver
uniprot
A0A7I2V2I8
resolver
uniprot
A0A7I2V4P6
resolver
uniprot
A0A7I2V5H3
resolver
uniprot
A8K3I6
resolver
uniprot
B4DJC7
resolver
uniprot
Q53G24
resolver
uniprot
Q6X7T5
resolver
uniprot
Q8NDK4
resolver
uniprot_entry
A0A7I2V2I8_HUMAN
resolver
uniprot_entry
A0A7I2V4P6_HUMAN
resolver
uniprot_entry
A0A7I2V5H3_HUMAN
resolver
uniprot_entry
B4DJC7_HUMAN
resolver
uniprot_entry
PRKRA_HUMAN
resolver
uniprot_sec
A8K3I6
resolver
uniprot_sec
Q53G24
resolver
uniprot_sec
Q6X7T5
resolver
uniprot_sec
Q8NDK4
resolver
amino_acid_sequence
MSQSRHRAEAPPLEREDSGTFSLGKMITAKPGKTPIQVLHEYGMKTKNIPVYECERSDVQIHVPTFTFRVTVGDITCTGEGTSKKLAKHRAAEAAINILKANASICFAVPDPLMPDPSKQPKNQLNPIGSLQELAIHHGWRLPEYTLSQEGGPAHKREYTTICRLESFMETGKGASKKQAKRNAAEKFLAKFSNISPENHISLTNVVGHSLGCTWHSLRNSPGEKINLLKRSLLSIPNTDYIQLLSEIAKEQGFNITYLDIDELSANGQYQCLAELSTSPITVCHGSGISCGNAQSDAAHNALQYLKIIAERK
uniprot
proteins
disease_involvement
DISEASE: Dystonia 16 (DYT16) [MIM:612067]: An early-onset dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT16 patients have progressive, generalized dystonia with axial muscle involvement, oro-mandibular (sardonic smile) and laryngeal dystonia and, in some cases, parkinsonian features. {ECO:0000269|PubMed:18243799, ECO:0000269|PubMed:18420150}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). May function as regulator of gastric epithelial differentiation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9WTX2, ECO:0000269|PubMed:10336432, ECO:0000269|PubMed:11238927, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:16982605, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:9687506}.
uniprot
proteins
mass_dalton
34404
uniprot
proteins
mutagenesis
MUTAGEN 18; /note="S->A: No effect on apoptosis induction under conditions of stress."; /evidence="ECO:0000269|PubMed:16982605"; MUTAGEN 18; /note="S->D: Does not induce apoptosis."; /evidence="ECO:0000269|PubMed:16982605"; MUTAGEN 243; /note="Q->A: Abrogates apoptosis induction under conditions of stress."; /evidence="ECO:0000269|PubMed:16982605"; MUTAGEN 246; /note="S->A: Abrogates apoptosis induction under conditions of stress and binding to EIF2AK2. Prevents activation of EIF2AK2 in stressed cells; when associated with A-287."; /evidence="ECO:0000269|PubMed:16982605"; MUTAGEN 246; /note="S->D: Induces activation of EIF2AK2 and apoptosis in unstressed cells; when associated with D-287."; /evidence="ECO:0000269|PubMed:16982605"; MUTAGEN 260; /note="D->A: Abrogates apoptosis induction under conditions of stress."; /evidence="ECO:0000269|PubMed:16982605"; MUTAGEN 262; /note="D->A: Abrogates apoptosis induction under conditions of stress."; /evidence="ECO:0000269|PubMed:16982605"; MUTAGEN 265; /note="S->A: Abrogates apoptosis induction under conditions of stress."; /evidence="ECO:0000269|PubMed:16982605"; MUTAGEN 271; /note="Q->A: Abrogates apoptosis induction under conditions of stress."; /evidence="ECO:0000269|PubMed:16982605"; MUTAGEN 279; /note="S->A: Abrogates apoptosis induction under conditions of stress."; /evidence="ECO:0000269|PubMed:16982605"; MUTAGEN 287; /note="S->A: Abrogates apoptosis induction under conditions of stress. Prevents activation of EIF2AK2 in stressed cells; when associated with A-246."; /evidence="ECO:0000269|PubMed:16982605"; MUTAGEN 287; /note="S->D: Induces activation of EIF2AK2 and apoptosis in unstressed cells; when associated with D-246."; /evidence="ECO:0000269|PubMed:16982605"; MUTAGEN 288; /note="G->A: Abrogates apoptosis induction under conditions of stress."; /evidence="ECO:0000269|PubMed:16982605"; MUTAGEN 291; /note="C->A: Abrogates apoptosis induction under conditions of stress."; /evidence="ECO:0000269|PubMed:16982605"; MUTAGEN 298..299; /note="AA->KK: Abrogates interaction with DICER1 but does not affect interaction with AGO2."; /evidence="ECO:0000269|PubMed:16424907
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-246 in unstressed cells and at Ser-287 in stressed cells. Phosphorylation at Ser-246 appears to be a prerequisite for subsequent phosphorylation at Ser-287. Phosphorylation at Ser-246 and Ser-287 are necessary for activation of EIF2AK2/PKR under conditions of stress. {ECO:0000269|PubMed:16982605}.
uniprot
proteins
protein_family
PRKRA family
uniprot
proteins
pubmed
10336432
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11238927
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16424907
uniprot
proteins
pubmed
16982605
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17452327
uniprot
proteins
pubmed
18096616
uniprot
proteins
pubmed
18243799
uniprot
proteins
pubmed
18420150
uniprot
proteins
pubmed
18421256
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21228243
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22214662
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23870315
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29084250
uniprot
proteins
pubmed
9687506
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Cytoplasm.
uniprot
proteins