RTN3
entrez
10313
canonical
uniprot
O95197
canonical
ensembl
ENSG00000133318
resolver
ensp
ENSP00000340903
resolver
ensp
ENSP00000344106
resolver
ensp
ENSP00000346492
resolver
ensp
ENSP00000348279
resolver
ensp
ENSP00000367050
resolver
ensp
ENSP00000440874
resolver
ensp
ENSP00000442733
resolver
ensp
ENSP00000646178
resolver
ensp
ENSP00000682467
resolver
genesymbol
RTN3
resolver
genesymbol_syn
ASYIP
resolver
genesymbol_syn
NSPL2
resolver
hgnc
HGNC:10469
resolver
uniprot
B3KQS2
resolver
uniprot
B7Z308
resolver
uniprot
B7Z4M0
resolver
uniprot
F5H774
resolver
uniprot
Q147U9
resolver
uniprot
Q496K2
resolver
uniprot
Q53GN3
resolver
uniprot
Q59EP0
resolver
uniprot
Q5UEP2
resolver
uniprot
Q6T930
resolver
uniprot
Q7RTM7
resolver
uniprot
Q7RTM8
resolver
uniprot
Q7RTN3
resolver
uniprot_entry
RTN3_HUMAN
resolver
uniprot_sec
B3KQS2
resolver
uniprot_sec
B7Z308
resolver
uniprot_sec
B7Z4M0
resolver
uniprot_sec
F5H774
resolver
uniprot_sec
Q147U9
resolver
uniprot_sec
Q496K2
resolver
uniprot_sec
Q53GN3
resolver
uniprot_sec
Q59EP0
resolver
uniprot_sec
Q5UEP2
resolver
uniprot_sec
Q6T930
resolver
uniprot_sec
Q7RTM7
resolver
uniprot_sec
Q7RTM8
resolver
uniprot_sec
Q7RTN3
resolver
amino_acid_sequence
MAEPSAATQSHSISSSSFGAEPSAPGGGGSPGACPALGTKSCSSSCADSFVSSSSSQPVSLFSTSQEGLSSLCSDEPSSEIMTSSFLSSSEIHNTGLTILHGEKSHVLGSQPILAKEGKDHLDLLDMKKMEKPQGTSNNVSDSSVSLAAGVHCDRPSIPASFPEHPAFLSKKIGQVEEQIDKETKNPNGVSSREAKTALDADDRFTLLTAQKPPTEYSKVEGIYTYSLSPSKVSGDDVIEKDSPESPFEVIIDKAAFDKEFKDSYKESTDDFGSWSVHTDKESSEDISETNDKLFPLRNKEAGRYPMSALLSRQFSHTNAALEEVSRCVNDMHNFTNEILTWDLVPQVKQQTDKSSDCITKTTGLDMSEYNSEIPVVNLKTSTHQKTPVCSIDGSTPITKSTGDWAEASLQQENAITGKPVPDSLNSTKEFSIKGVQGNMQKQDDTLAELPGSPPEKCDSLGSGVATVKVVLPDDHLKDEMDWQSSALGEITEADSSGESDDTVIEDITADTSFENNKIQAEKPVSIPSAVVKTGEREIKEIPSCEREEKTSKNFEELVSDSELHQDQPDILGRSPASEAACSKVPDTNVSLEDVSEVAPEKPITTENPKLPSTVSPNVFNETEFSLNVTTSAYLESLHGKNVKHIDDSSPEDLIAAFTETRDKGIVDSERNAFKAISEKMTDFKTTPPVEVLHENESGGSEIKDIGSKYSEQSKETNGSEPLGVFPTQGTPVASLDLEQEQLTIKALKELGERQVEKSTSAQRDAELPSEEVLKQTFTFAPESWPQRSYDILERNVKNGSDLGISQKPITIRETTRVDAVSSLSKTELVKKHVLARLLTDFSVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE
uniprot
proteins
function
FUNCTION: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}.
uniprot
proteins
mass_dalton
112611
uniprot
proteins
pubmed
10331947
uniprot
proteins
pubmed
12811824
uniprot
proteins
pubmed
12832288
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14986927
uniprot
proteins
pubmed
15286784
uniprot
proteins
pubmed
15350194
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15946766
uniprot
proteins
pubmed
16054885
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16965550
uniprot
proteins
pubmed
16979658
uniprot
proteins
pubmed
17031492
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17182608
uniprot
proteins
pubmed
17191123
uniprot
proteins
pubmed
17699523
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19665976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21976701
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24262037
uniprot
proteins
pubmed
25612671
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29117567
uniprot
proteins
pubmed
32620754
uniprot
proteins
pubmed
34313226
uniprot
proteins
sequence_length
1032
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12811824, ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:16979658, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17182608, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:29117567, ECO:0000269|PubMed:34313226}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:16979658, ECO:0000269|PubMed:29117567}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins