FABP6
entrez
2172
canonical
uniprot
P51161
canonical
ensembl
ENSG00000170231
resolver
ensp
ENSP00000377549
resolver
ensp
ENSP00000385433
resolver
genesymbol
FABP6
resolver
genesymbol_syn
ILBP
resolver
genesymbol_syn
ILLBP
resolver
hgnc
HGNC:3561
resolver
uniprot
Q07DR7
resolver
uniprot
Q8TBI3
resolver
uniprot
Q9UGI7
resolver
uniprot_entry
FABP6_HUMAN
resolver
uniprot_sec
Q07DR7
resolver
uniprot_sec
Q8TBI3
resolver
uniprot_sec
Q9UGI7
resolver
amino_acid_sequence
MAFTGKFEMESEKNYDEFMKLLGISSDVIEKARNFKIVTEVQQDGQDFTWSQHYSGGHTMTNKFTVGKESNIQTMGGKTFKATVQMEGGKLVVNFPNYHQTSEIVGDKLVEVSTIGGVTYERVSKRLA
uniprot
proteins
function
FUNCTION: Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity). {ECO:0000250|UniProtKB:P10289, ECO:0000250|UniProtKB:P51162, ECO:0000269|PubMed:12486725, ECO:0000269|PubMed:7588781}.; FUNCTION: [Isoform 2]: Essential for the survival of colon cancer cells to bile acid-induced apoptosis. {ECO:0000269|PubMed:17909007}.
uniprot
proteins
mass_dalton
14371
uniprot
proteins
protein_family
Calycin superfamily
uniprot
proteins
protein_family
Fatty-acid binding protein (FABP) family
uniprot
proteins
pubmed
11461829
uniprot
proteins
pubmed
12486725
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17909007
uniprot
proteins
pubmed
19744871
uniprot
proteins
pubmed
26613247
uniprot
proteins
pubmed
7588781
uniprot
proteins
pubmed
7619861
uniprot
proteins
sequence_length
128
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:P80020}. Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:P50119}; Cytoplasmic side {ECO:0000250|UniProtKB:P50119}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:17909007}. Note=Localized close to nucleus on the apical side of both normal and neoplastic cells. {ECO:0000269|PubMed:17909007}.
uniprot
proteins