SYCP2L
entrez
221711
canonical
uniprot
Q5T4T6
canonical
ensembl
ENSG00000153157
resolver
ensp
ENSP00000283141
resolver
genesymbol
SYCP2L
resolver
genesymbol_syn
C6orf177
resolver
genesymbol_syn
NO145
resolver
hgnc
HGNC:21537
resolver
uniprot
A6NDS5
resolver
uniprot
B4DFB8
resolver
uniprot
Q08GK5
resolver
uniprot
Q6ZRM2
resolver
uniprot
Q96EJ2
resolver
uniprot_entry
B4DFB8_HUMAN
resolver
uniprot_entry
SYC2L_HUMAN
resolver
uniprot_sec
A6NDS5
resolver
uniprot_sec
Q08GK5
resolver
uniprot_sec
Q6ZRM2
resolver
uniprot_sec
Q96EJ2
resolver
amino_acid_sequence
MQAKNKDALQPIKEDRTGKAQDDAFWLQSLITDAFHDKGFQKIKEYFQQKESHFPQKYNRLLLYRLDRSINKELDKNEFQSVSLLLKCIQRFLVDGLKEDEPLLIRQGLIPKLVSWFERTTGILTSEGLASDTSLICVIEDFFDTALIISRSSSEGKIQMLDSFLLSLGFLVTEKTVNHLLQQEGLKTFNCILHAVPREERKKFPLSEGMCHLMKDLARTLLTVGDYDQQVAISEALCRLTIKKSRDELVHKWFDDEVIAEAFKEIKDREFETDSRRFLNHLNNRLGDQRRVYSFPCIAAFADEHEMRKPADEKLEKFWIDFNLGSQSVTFYIDNAENTLWDSVTLPKEAVMNFSITETEKIKIFIIYLKKPMIISYKEVMKIEIHFDLQFNISQVSIQALGEDKQMLPDQTKISSELFSKSDKEDRESPSGLERETEQAEESTNMVEFMSAEDDRCLITLHLNDQSEPPVIGEPASDSHLQPVPPFGVPDFPQQPKSHYRKHLFSESNQDSSTSELSWTSNQKKKSLKSYSSRKKTRTRSNLRILPVFPPSSGSGHEKDQAKLLSPSEKEIPEQNNTTSPKTSEQKFQDSFAFLTAEDSAQKTELQDPHSLSELSSLKHSEDEEKPKIVNQESLTESTSLKHKLRNLEDKDIPEGSFAKSQQSRLEEEVAPGSPFSITEERELPEGISTSSLEVVPENLNGSAILPTFENFTKKRKRKYELRYRKRPFNSENAKKAPDCLIKLLNQMQLFRLNKLERFQNLVLQELSSLKQDIQALEHLEKEVLEFWGKQSADLQSFCDLQVLRFNSTQTS
uniprot
proteins
disease_involvement
DISEASE: Premature ovarian failure 24 (POF24) [MIM:620840]: A form of premature ovarian failure, an ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. POF24 inheritance is autosomal recessive. {ECO:0000269|PubMed:32303603}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes. {ECO:0000250|UniProtKB:A0A0M3U1B0}.
uniprot
proteins
mass_dalton
93599
uniprot
proteins
protein_family
SYCP2 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17374641
uniprot
proteins
pubmed
23033978
uniprot
proteins
pubmed
26362258
uniprot
proteins
pubmed
32303603
uniprot
proteins
sequence_length
812
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17374641}. Chromosome, centromere {ECO:0000269|PubMed:26362258, ECO:0000269|PubMed:32303603}. Note=Localized to the synaptonemal complex lateral elements in late diplotene oocytes, while it is absent on the synaptonemal complex of leptotene, zygotene, pachytene and early diplotene oocytes (By similarity). Localizes to centromeres in dictyate oocytes (By similarity). Detected in nuclear granules and sizable aggregates (PubMed:17374641). {ECO:0000250|UniProtKB:A0A0M3U1B0, ECO:0000269|PubMed:17374641}.
uniprot
proteins