Slc6a11
entrez
243616
canonical
uniprot
P31650
canonical
ensembl
ENSMUSG00000030307
resolver
ensp
ENSMUSP00000032451
resolver
enst
ENSMUST00000032451
resolver
genesymbol
Slc6a11
resolver
genesymbol_syn
Gabt3
resolver
genesymbol_syn
Gabt4
resolver
genesymbol_syn
Gat-4
resolver
genesymbol_syn
Gat3
resolver
genesymbol_syn
Gat4
resolver
uniprot
Q8BWA7
resolver
uniprot_entry
S6A11_MOUSE
resolver
uniprot_sec
Q8BWA7
resolver
activity_regulation
ACTIVITY REGULATION: GABA transport is inhibited by beta-alanine, taurine, hypotaurine, beta-guanidinopropionic acid and 2,3-diaminopropionic acid (PubMed:8420981). Beta-alanine transport is inhibited by GABA (PubMed:8420981). {ECO:0000269|PubMed:8420981}.
uniprot
proteins
amino_acid_sequence
MTAEQALPLGNGKAAEEARGSETLGGGGGGAAGTREARDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPRTVTVNDCEAKVKGDGTISAITEKETHF
uniprot
proteins
function
FUNCTION: Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:30270321, PubMed:8420981). Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (PubMed:30270321, PubMed:8420981). {ECO:0000269|PubMed:30270321, ECO:0000269|PubMed:8420981}.
uniprot
proteins
mass_dalton
69961
uniprot
proteins
protein_family
SLC6A11 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30270321
uniprot
proteins
pubmed
8420981
uniprot
proteins
sequence_length
627
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P31647}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 54..74; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 82..101; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 126..146; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 221..239; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 248..265; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 301..318; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 330..351; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 384..403; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 433..451; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 468..488; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 509..528; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 548..566; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins