Sqle
entrez
29230
canonical
uniprot
P52020
canonical
ensembl
ENSRNOG00000009550
resolver
ensembl
ENSRNOG00065002388
resolver
ensembl
ENSRNOG00065004951
resolver
ensp
ENSRNOP00000012883
resolver
ensp
ENSRNOP00065002145
resolver
ensp
ENSRNOP00065004986
resolver
enst
ENSRNOT00000012883
resolver
enst
ENSRNOT00065003139
resolver
enst
ENSRNOT00065007206
resolver
genesymbol
Sqle
resolver
genesymbol_syn
Erg1
resolver
uniprot
Q4V8L3
resolver
uniprot_entry
ERG1_RAT
resolver
uniprot_sec
Q4V8L3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by NB-598 ((E)N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-[(3,3'-bi-thiophen-5-yl)methoxy]benzene-methanamine). Contrary to fungal enzymes, the mammalian enzyme is only slightly inhibited by terbinafine. {ECO:0000269|PubMed:7814369}.
uniprot
proteins
amino_acid_sequence
MWTFLGIATFTYFYKKCGDVTLANKELLLCVLVFLSLGLVLSYRCRHRNGGLLGRHQSGSQFAAFSDILSALPLIGFFWAKSPPESEKKEQLESKRRRKEVNLSETTLTGAATSVSTSSVTDPEVIIIGSGVLGSALATVLSRDGRTVTVIERDLKEPDRILGECLQPGGYRVLRELGLGDTVESLNAHHIHGYVIHDCESRSEVQIPYPVSENNQVQSGVAFHHGKFIMSLRKAAMAEPNVKFIEGVVLRLLEEDDAVIGVQYKDKETGDTKELHAPLTVVADGLFSKFRKNLISNKVSVSSHFVGFIMKDAPQFKANFAELVLVDPSPVLIYQISPSETRVLVDIRGELPRNLREYMTEQIYPQIPDHLKESFLEACQNARLRTMPASFLPPSSVNKRGVLLLGDAYNLRHPLTGGGMTVALKDIKIWRQLLKDIPDLYDDAAIFQAKKSFFWSRKRSHSFVVNVLAQALYELFSATDDSLRQLRKACFLYFKLGGECLTGPVGLLSILSPDPLLLIRHFFSVAVYATYFCFKSEPWATKPRALFSSGAILYKACSIIFPLIYSEMKYLVH
uniprot
proteins
ec_number
1.14.14.17
uniprot
proteins
function
FUNCTION: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. {ECO:0000269|PubMed:17112472, ECO:0000269|PubMed:7814369}.
uniprot
proteins
mass_dalton
64024
uniprot
proteins
mutagenesis
MUTAGEN 194; /note="Y->A: Strongly decreased catalytic activity."; /evidence="ECO:0000269|PubMed:17112472"; MUTAGEN 209; /note="Y->A: Nearly abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:17112472"; MUTAGEN 223; /note="F->A: Increased enzyme activity."; /evidence="ECO:0000269|PubMed:17112472"; MUTAGEN 228; /note="F->A: Strongly decreased affinity for squalene."; /evidence="ECO:0000269|PubMed:17112472"; MUTAGEN 287; /note="F->A: Decreased enzyme activity."; /evidence="ECO:0000269|PubMed:17112472"; MUTAGEN 305; /note="F->A: Decreased enzyme activity."; /evidence="ECO:0000269|PubMed:17112472"; MUTAGEN 334; /note="Y->A: Decreased enzyme activity."; /evidence="ECO:0000269|PubMed:17112472"; MUTAGEN 473; /note="Y->A: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:17112472"; MUTAGEN 476; /note="F->A: Decreased enzyme activity."; /evidence="ECO:0000269|PubMed:17112472"; MUTAGEN 491; /note="F->A: Decreased enzyme activity."; /evidence="ECO:0000269|PubMed:17112472"; MUTAGEN 522; /note="F->A: Decreased enzyme activity."; /evidence="ECO:0000269|PubMed:17112472"; MUTAGEN 523; /note="F->A: Decreased enzyme activity."; /evidence="ECO:0000269|PubMed:17112472"; MUTAGEN 528; /note="Y->A: Decreased enzyme activity."; /evidence="ECO:0000269|PubMed:17112472
uniprot
proteins
pathway_participation
PATHWAY: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3. {ECO:0000305|PubMed:7814369}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MARCHF6 in response to high cholesterol levels in intracellular membranes, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q14534}.
uniprot
proteins
protein_family
Squalene monooxygenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17112472
uniprot
proteins
pubmed
7814369
uniprot
proteins
sequence_length
573
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:7814369}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14534}. Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14534}.
uniprot
proteins