DRAP1
entrez
10589
canonical
uniprot
Q14919
canonical
ensembl
ENSG00000175550
resolver
ensp
ENSP00000307850
resolver
genesymbol
DRAP1
resolver
hgnc
HGNC:3019
resolver
uniprot
Q13448
resolver
uniprot_entry
NC2A_HUMAN
resolver
uniprot_sec
Q13448
resolver
amino_acid_sequence
MPSKKKKYNARFPPARIKKIMQTDEEIGKVAAAVPVIISRALELFLESLLKKACQVTQSRNAKTMTTSHLKQCIELEQQFDFLKDLVASVPDMQGDGEDNHMDGDKGARRGRKPGSGGRKNGGMGTKSKDKKLSGTDSEQEDESEDTDTDGEEETSQPPPQASHPSAHFQSPPTPFLPFASTLPLPPAPPGPSAPDEEDEEDYDS
uniprot
proteins
function
FUNCTION: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. {ECO:0000269|PubMed:8608938, ECO:0000269|PubMed:8670811}.
uniprot
proteins
mass_dalton
22350
uniprot
proteins
post_translational_modification
PTM: Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding. {ECO:0000269|PubMed:8608938, ECO:0000269|PubMed:8670811}.
uniprot
proteins
protein_family
NC2 alpha/DRAP1 family
uniprot
proteins
pubmed
11461703
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15509807
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
8608938
uniprot
proteins
pubmed
8670811
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins