TRDN
entrez
10345
canonical
uniprot
Q13061
canonical
ensembl
ENSG00000186439
resolver
ensp
ENSP00000333984
resolver
ensp
ENSP00000437684
resolver
ensp
ENSP00000439281
resolver
ensp
ENSP00000486095
resolver
ensp
ENSP00000499585
resolver
ensp
ENSP00000682156
resolver
enst
ENST00000546248
resolver
enst
ENST00000662930
resolver
genesymbol
TRDN
resolver
hgnc
HGNC:12261
resolver
uniprot
A0A0A0MTH1
resolver
uniprot
A0A590UJV0
resolver
uniprot
A5D6W5
resolver
uniprot
F5H2W7
resolver
uniprot
H9ME53
resolver
uniprot
Q6NSB8
resolver
uniprot
Q8IVK2
resolver
uniprot_entry
A0A0A0MTH1_HUMAN
resolver
uniprot_entry
A0A590UJV0_HUMAN
resolver
uniprot_entry
H9ME53_HUMAN
resolver
uniprot_entry
Q8IVK2_HUMAN
resolver
uniprot_entry
TRDN_HUMAN
resolver
uniprot_sec
A5D6W5
resolver
uniprot_sec
F5H2W7
resolver
uniprot_sec
Q6NSB8
resolver
amino_acid_sequence
MTEITAEGNASTTTTVIDSKNGSVPKSPGKVLKRTVTEDIVTTFSSPAAWLLVIALIITWSAVAIVMFDLVDYKNFSASSIAKIGSDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKSPISFFQCVYLDGYNGYGFQFPFTPADRPGESSGQANSPGQKQQGQ
uniprot
proteins
disease_involvement
DISEASE: Cardiac arrhythmia syndrome, with or without skeletal muscle weakness (CARDAR) [MIM:615441]: An autosomal recessive cardiac disorder characterized by stress-induced arrhythmias in infancy or early childhood. Patients present with recurrent syncope or cardiac arrest after physical activity or emotional stress. Sudden death may occur in early childhood. Some patients have muscle weakness. {ECO:0000269|PubMed:22422768}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000250|UniProtKB:E9Q9K5, ECO:0000269|PubMed:22422768}.
uniprot
proteins
mass_dalton
81595
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CaMK2. {ECO:0000250|UniProtKB:Q28820}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:E9Q9K5}.
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15485681
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22422768
uniprot
proteins
pubmed
24325401
uniprot
proteins
pubmed
7588753
uniprot
proteins
sequence_length
729
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22422768}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:22422768, ECO:0000269|PubMed:24325401}; Single-pass type II membrane protein {ECO:0000269|PubMed:22422768, ECO:0000269|PubMed:24325401}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..68; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins