SLU7
entrez
10569
canonical
uniprot
O95391
canonical
ensembl
ENSG00000164609
resolver
ensp
ENSP00000297151
resolver
ensp
ENSP00000525688
resolver
ensp
ENSP00000608566
resolver
ensp
ENSP00000608568
resolver
enst
ENST00000297151
resolver
enst
ENST00000855629
resolver
enst
ENST00000938507
resolver
enst
ENST00000938509
resolver
genesymbol
SLU7
resolver
hgnc
HGNC:16939
resolver
uniprot
D3DQK2
resolver
uniprot
Q3LUJ0
resolver
uniprot
Q3LUJ1
resolver
uniprot
Q6RXQ5
resolver
uniprot
Q96FM9
resolver
uniprot_entry
SLU7_HUMAN
resolver
uniprot_sec
D3DQK2
resolver
uniprot_sec
Q3LUJ0
resolver
uniprot_sec
Q3LUJ1
resolver
uniprot_sec
Q6RXQ5
resolver
uniprot_sec
Q96FM9
resolver
amino_acid_sequence
MSATVVDAVNAAPLSGSKEMSLEEPKKMTREDWRKKKELEEQRKLGNAPAEVDEEGKDINPHIPQYISSVPWYIDPSKRPTLKHQRPQPEKQKQFSSSGEWYKRGVKENSIITKYRKGACENCGAMTHKKKDCFERPRRVGAKFTGTNIAPDEHVQPQLMFDYDGKRDRWNGYNPEEHMKIVEEYAKVDLAKRTLKAQKLQEELASGKLVEQANSPKHQWGEEEPNSQMEKDHNSEDEDEDKYADDIDMPGQNFDSKRRITVRNLRIREDIAKYLRNLDPNSAYYDPKTRAMRENPYANAGKNPDEVSYAGDNFVRYTGDTISMAQTQLFAWEAYDKGSEVHLQADPTKLELLYKSFKVKKEDFKEQQKESILEKYGGQEHLDAPPAELLLAQTEDYVEYSRHGTVIKGQERAVACSKYEEDVKIHNHTHIWGSYWKEGRWGYKCCHSFFKYSYCTGEAGKEIVNSEECIINEITGEESVKKPQTLMELHQEKLKEEKKKKKKKKKKHRKSSSDSDDEEKKHEKLKKALNAEEARLLHVKETMQIDERKRPYNSMYETREPTEEEMEAYRMKRQRPDDPMASFLGQ
uniprot
proteins
function
FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (PubMed:10197984, PubMed:28502770, PubMed:30705154). Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000269|PubMed:10197984, ECO:0000269|PubMed:10647016, ECO:0000269|PubMed:12764196, ECO:0000269|PubMed:15181151, ECO:0000269|PubMed:15728250, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:30705154}.
uniprot
proteins
mass_dalton
68387
uniprot
proteins
mutagenesis
MUTAGEN 116; /note="R->N: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:15181151"; MUTAGEN 117; /note="K->N: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:15181151"; MUTAGEN 120; /note="C->S: Induces a cytoplasmic localization; when associated with S-123; G-128 and S-133."; /evidence="ECO:0000269|PubMed:15181151"; MUTAGEN 123; /note="C->S: Induces a cytoplasmic localization; when associated with S-120; G-128 and S-133."; /evidence="ECO:0000269|PubMed:15181151"; MUTAGEN 125..126; /note="AM->VP: Does not affect nuclear localization."; /evidence="ECO:0000269|PubMed:15181151"; MUTAGEN 128; /note="H->G: Induces a cytoplasmic localization; when associated with S-120; S-123 and S-133."; /evidence="ECO:0000269|PubMed:15181151"; MUTAGEN 129; /note="K->N: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:15181151"; MUTAGEN 133; /note="C->S: Induces a cytoplasmic localization; when associated with S-120; S-123 and G-128."; /evidence="ECO:0000269|PubMed:15181151"; MUTAGEN 136; /note="R->N: Abolishes nuclear localization."; MUTAGEN 166; /note="K->N: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:15181151
uniprot
proteins
protein_family
SLU7 family
uniprot
proteins
pubmed
10197984
uniprot
proteins
pubmed
10647016
uniprot
proteins
pubmed
12764196
uniprot
proteins
pubmed
15181151
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15728250
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21122810
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28502770
uniprot
proteins
pubmed
30705154
uniprot
proteins
sequence_length
586
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10197984, ECO:0000269|PubMed:15728250, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:30705154}. Nucleus speckle {ECO:0000269|PubMed:15181151}. Cytoplasm {ECO:0000269|PubMed:15728250}. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules. {ECO:0000269|PubMed:15728250}.
uniprot
proteins