Ift88
entrez
21821
canonical
uniprot
Q61371
canonical
ensembl
ENSMUSG00000040040
resolver
ensp
ENSMUSP00000113768
resolver
ensp
ENSMUSP00000299936
resolver
ensp
ENSMUSP00000299937
resolver
enst
ENSMUST00000122063
resolver
genesymbol
Ift88
resolver
genesymbol_syn
Tg737
resolver
genesymbol_syn
Tg737Rpw
resolver
genesymbol_syn
TgN737Rpw
resolver
genesymbol_syn
Ttc10
resolver
uniprot
E9QKU0
resolver
uniprot
G3X9Z7
resolver
uniprot
Q3TUP2
resolver
uniprot
Q3UXY9
resolver
uniprot
Q921J5
resolver
uniprot_entry
G3X9Z7_MOUSE
resolver
uniprot_entry
IFT88_MOUSE
resolver
uniprot_entry
Q3TUP2_MOUSE
resolver
uniprot_sec
E9QKU0
resolver
uniprot_sec
Q3UXY9
resolver
uniprot_sec
Q921J5
resolver
amino_acid_sequence
MENVHLAPETDEDDLYSGFNDYNPAYDTEELENDTGFQQAVRTSHGRRPPVTAKIPSTAVSRPIATGYGSKTSLTSSMGRPMTGTIQDGVARPMTAVRAAGFSKAALRGSAFDPLGQSRGPAPPLEAKNEDSPEEKIRQLEKKVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTSPENINLDLTYSVLFNLASQYSANEMYAEALNTYQVIVKNKMFSNAGRLKVNMGNIYLKQRNYSKAIKFYRMALDQIPSVHKEMRIKIMQNIGITFIKTGQYSDAINSFEHIMSMAPSLKAGFNLILSCFAIGDREKMKKAFQKLIAVPLEIDEDDKYISPSDDPHTNLLIEAIKNDHLRQMERERKAMAEKYIMTAAKLIAPVIEASFAVGYNWCVEVVKASQYVELANDLEINKAITYLRQKDFNQAVDTLKMFEKKDSRVKSAAATNLSFLYYLENEFAQASSYADLAVNSDRYNPSALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYKKLNRLDEALDSFLKLHAILRNSAQVLCQIANIYELMEDPNQAIEWLMQLISVVPTDSQALSKLGELYDSEGDKSQAFQYYYESYRYFPSNIEVIEWLGAYYIDTQFCEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKEIHRKFPENVECLRFLVRLCTDIGLKEVQEYATKLKRLEKMKEMREQRIKSGRDSSGGSRSKREGSAGSDSGQNNSASSKSERLSAKLRALPGTDEPYESSGNKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Ift88 are the cause of recessive bilateral polycystic kidney disease (PKD) with collecting duct and tubule ectasia, and a liver lesion involving biliary dysplasia and/or portal fibrosis.
uniprot
proteins
function
FUNCTION: Positively regulates primary cilium biogenesis (PubMed:11062270, PubMed:21289087, PubMed:31761534). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. {ECO:0000269|PubMed:11062270, ECO:0000269|PubMed:21289087, ECO:0000269|PubMed:31761534}.
uniprot
proteins
mass_dalton
92994
uniprot
proteins
pubmed
11062270
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17312020
uniprot
proteins
pubmed
19253336
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20230748
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21289087
uniprot
proteins
pubmed
23386061
uniprot
proteins
pubmed
23810713
uniprot
proteins
pubmed
23955340
uniprot
proteins
pubmed
24089209
uniprot
proteins
pubmed
24469809
uniprot
proteins
pubmed
27682589
uniprot
proteins
pubmed
31761534
uniprot
proteins
pubmed
34124066
uniprot
proteins
pubmed
35587122
uniprot
proteins
pubmed
37352829
uniprot
proteins
pubmed
38038747
uniprot
proteins
pubmed
8191288
uniprot
proteins
sequence_length
824
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:20230748, ECO:0000269|PubMed:23386061}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:19253336, ECO:0000269|PubMed:20230748}. Cell projection, cilium {ECO:0000250|UniProtKB:Q13099}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q13099}. Cytoplasm {ECO:0000269|PubMed:27682589}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:27682589, ECO:0000269|PubMed:34124066}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:34124066, ECO:0000269|PubMed:37352829}. Note=Colocalizes with ENTR1 and gamma-tubulin at the basal body of primary cilia (By similarity). Colocalizes with ENTR1 and pericentrin at the centrosome (By similarity). In sperm cells, localizes to the manchette, head-tail coupling apparatus and flagellum (PubMed:34124066). Localizes to the manchette in elongating spermatids in a CFAP70-dependent manner (PubMed:37352829). {ECO:0000250|UniProtKB:Q13099, ECO:0000269|PubMed:34124066, ECO:0000269|PubMed:37352829}.
uniprot
proteins