ASIC2
entrez
40
canonical
uniprot
Q16515
canonical
ensembl
ENSG00000108684
resolver
ensp
ENSP00000225823
resolver
ensp
ENSP00000352934
resolver
genesymbol
ASIC2
resolver
genesymbol_syn
ACCN
resolver
genesymbol_syn
ACCN1
resolver
hgnc
HGNC:99
resolver
uniprot
E9PBX2
resolver
uniprot
Q13553
resolver
uniprot
Q6DJU1
resolver
uniprot
Q8N3E2
resolver
uniprot_entry
ASIC2_HUMAN
resolver
uniprot_sec
E9PBX2
resolver
uniprot_sec
Q13553
resolver
uniprot_sec
Q6DJU1
resolver
uniprot_sec
Q8N3E2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the diuretic drug amiloride (PubMed:10842183, PubMed:8626462, PubMed:8631835). Inhibited by gadolinium ions, the heterotrimer with ASIC3 being more sensitive (PubMed:10842183). Heterotrimer composed of ASIC1 and ASIC2 are inhibited by the snake venom mambalgin-1 (PubMed:23034652). {ECO:0000269|PubMed:10842183, ECO:0000269|PubMed:23034652, ECO:0000269|PubMed:8626462, ECO:0000269|PubMed:8631835}.
uniprot
proteins
amino_acid_sequence
MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQTTLGTLEEIAC
uniprot
proteins
function
FUNCTION: Forms pH-gated trimeric sodium channels that act as postsynaptic excitatory sensors in the nervous system (PubMed:10842183, PubMed:23034652, PubMed:8626462, PubMed:8631835). Upon extracellular acidification, these channels generate rapid, transient inward currents that fully desensitize (PubMed:10842183). Highly selective for sodium, they are permeable to other cations (PubMed:8626462, PubMed:8631835). By forming heterotrimeric channels with ASIC1, could contribute to synaptic plasticity, learning, and memory. Additionally, as acid sensors at nerve terminals, plays a role in mechanosensation and phototransduction (By similarity). {ECO:0000250|UniProtKB:Q925H0, ECO:0000269|PubMed:10842183, ECO:0000269|PubMed:23034652, ECO:0000269|PubMed:8626462, ECO:0000269|PubMed:8631835}.
uniprot
proteins
mass_dalton
57709
uniprot
proteins
mutagenesis
MUTAGEN 430; /note="G->S: No effect on cation channel activity."; /evidence="ECO:0000269|PubMed:8631835"; MUTAGEN 430; /note="G->T,V,F,K: Increased cation channel activity; constitutively active."; /evidence="ECO:0000269|PubMed:8631835
uniprot
proteins
protein_family
ASIC2 subfamily
uniprot
proteins
protein_family
Amiloride-sensitive sodium channel (TC 1.A.6) family
uniprot
proteins
pubmed
10842183
uniprot
proteins
pubmed
11802773
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23034652
uniprot
proteins
pubmed
8626462
uniprot
proteins
pubmed
8631835
uniprot
proteins
pubmed
9037075
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10842183, ECO:0000269|PubMed:8626462}; Multi-pass membrane protein {ECO:0000269|Ref.10}. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes. {ECO:0000250|UniProtKB:Q925H0}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..64; /note="Helical"; /evidence="ECO:0000305|Ref.10, ECO:0007744|PDB:6L6P"; TRANSMEM 425..439; /note="Helical"; /evidence="ECO:0000305|Ref.10, ECO:0007744|PDB:6L6P
uniprot
proteins