Stac3
entrez
237611
canonical
uniprot
Q8BZ71
canonical
ensembl
ENSMUSG00000040287
resolver
ensp
ENSMUSP00000048148
resolver
ensp
ENSMUSP00000125124
resolver
enst
ENSMUST00000035839
resolver
enst
ENSMUST00000160019
resolver
genesymbol
Stac3
resolver
uniprot_entry
STAC3_MOUSE
resolver
amino_acid_sequence
MTEKEVVESPQPPFPGETPQSGLQRLKQLFKKGSPETAEMEPPPEPQANGEAVGAGGGPIYYIYEEEEEEEEEEEPPPEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFGKIPPGFRRAYSSPLYSDQQYAVSAANRNDPVFETLRVGVIMANKERKKGQADKKNPLAAMMEEEPESARPEEGKSQDGNNAEKDKKAEKKTPDDKNKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLFPTDFLEEI
uniprot
proteins
function
FUNCTION: Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization (PubMed:23818578, PubMed:27621462, PubMed:29467163). Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction (PubMed:23818578). Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane (PubMed:27621462). Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (PubMed:25548159, PubMed:27621462, PubMed:29467163). Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:25548159, PubMed:29363593). {ECO:0000269|PubMed:23818578, ECO:0000269|PubMed:25548159, ECO:0000269|PubMed:27621462, ECO:0000269|PubMed:29363593, ECO:0000269|PubMed:29467163}.
uniprot
proteins
mass_dalton
41000
uniprot
proteins
mutagenesis
MUTAGEN 104; /note="V->L: Loss of co-localization with CACNA1S and strongly decreased co-localization with CACNA1C; when associated with E-133."; /evidence="ECO:0000269|PubMed:28112192"; MUTAGEN 133; /note="Y->E: Loss of co-localization with CACNA1S and strongly decreased co-localization with CACNA1C; when associated with L-104."; /evidence="ECO:0000269|PubMed:28112192"; MUTAGEN 280; /note="W->S: Loss of normal excitation-contraction coupling. Loss of function in enhancing calcium channel activity."; /evidence="ECO:0000269|PubMed:27621462
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23626854
uniprot
proteins
pubmed
23818578
uniprot
proteins
pubmed
25548159
uniprot
proteins
pubmed
27621462
uniprot
proteins
pubmed
28112192
uniprot
proteins
pubmed
29363593
uniprot
proteins
pubmed
29467163
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28112192, ECO:0000269|PubMed:29467163}. Cell membrane, sarcolemma {ECO:0000269|PubMed:23818578, ECO:0000269|PubMed:28112192, ECO:0000269|PubMed:29363593, ECO:0000269|PubMed:29467163, ECO:0000305|PubMed:25548159}; Peripheral membrane protein {ECO:0000269|PubMed:29363593, ECO:0000269|PubMed:29467163, ECO:0000305|PubMed:25548159}; Cytoplasmic side {ECO:0000269|PubMed:29363593, ECO:0000269|PubMed:29467163, ECO:0000305|PubMed:25548159}. Cell membrane, sarcolemma, T-tubule {ECO:0000269|PubMed:23818578, ECO:0000269|PubMed:28112192, ECO:0000269|PubMed:29363593}. Note=Co-localizes with CACNA1S and CACNA1C on T-tubules. {ECO:0000269|PubMed:23818578, ECO:0000269|PubMed:28112192, ECO:0000269|PubMed:29363593}.
uniprot
proteins