Doc2b
entrez
81820
canonical
uniprot
P70610
canonical
ensembl
ENSRNOG00000060054
resolver
ensp
ENSRNOP00000077032
resolver
genesymbol
Doc2b
resolver
uniprot_entry
DOC2B_RAT
resolver
amino_acid_sequence
MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPTAAPRASAPPDAPARSPAATAGPRSPSDGARDDDEDVDQLFGAYGASPGPSPGPSPVRPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTISKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPSWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKAEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLKPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKTLEVTVWDYDIGKSNDFIGGVVLGINAKGERLKHWFDCLKNKDKRIERWHTLTNEIPGAVLSD
uniprot
proteins
function
FUNCTION: Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes. {ECO:0000269|PubMed:18596155, ECO:0000269|PubMed:20150444}.
uniprot
proteins
mass_dalton
45841
uniprot
proteins
mutagenesis
MUTAGEN 15..20; /note="QEHMAI->YKDWAF: Prevents diacylglycerol-induced localization to the plasma membrane. Probably prevents interaction with UNC13A."; /evidence="ECO:0000269|PubMed:15033971"; MUTAGEN 158; /note="H->A: Loss of calcium-dependent binding to liposomes and altered fusion-promoting activity; when associated with A-222 and A-360."; /evidence="ECO:0000269|PubMed:20150444"; MUTAGEN 218; /note="D->N: Binds liposomes in a calcium-independent manner; when associated with N-220."; /evidence="ECO:0000269|PubMed:18596155"; MUTAGEN 220; /note="D->N: Binds liposomes in a calcium-independent manner; when associated with N-218."; /evidence="ECO:0000269|PubMed:18596155"; MUTAGEN 222; /note="F->A: Loss of calcium-dependent binding to liposomes and altered fusion-promoting activity; when associated with A-158 and A-360."; /evidence="ECO:0000269|PubMed:20150444"; MUTAGEN 237; /note="K->E: Loss of calcium-independent binding to liposomes. Loss of interaction with the SNARE complex and altered fusion-promoting activity; when associated with E-319."; /evidence="ECO:0000269|PubMed:20150444"; MUTAGEN 319; /note="K->E: Loss of calcium-independent binding to liposomes. Loss of interaction with the SNARE complex and altered fusion-promoting activity; when associated with E-237."; /evidence="ECO:0000269|PubMed:20150444"; MUTAGEN 360; /note="I->A: Loss of calcium-dependent binding to liposomes and altered fusion-promoting activity; when associated with A-158 and A-222."; /evidence="ECO:0000269|PubMed:20150444
uniprot
proteins
pubmed
15033971
uniprot
proteins
pubmed
18596155
uniprot
proteins
pubmed
20150444
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9115738
uniprot
proteins
pubmed
9804756
uniprot
proteins
sequence_length
412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic granule {ECO:0000250}. Cell membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane in a calcium-dependent manner.
uniprot
proteins