ARFGAP2
entrez
84364
canonical
uniprot
Q8N6H7
canonical
ensembl
ENSG00000149182
resolver
ensp
ENSP00000400226
resolver
ensp
ENSP00000434442
resolver
ensp
ENSP00000434809
resolver
ensp
ENSP00000562937
resolver
ensp
ENSP00000562938
resolver
ensp
ENSP00000562948
resolver
enst
ENST00000426335
resolver
enst
ENST00000525314
resolver
genesymbol
ARFGAP2
resolver
genesymbol_syn
ZNF289
resolver
hgnc
HGNC:13504
resolver
uniprot
B4DX29
resolver
uniprot
B7Z9M7
resolver
uniprot
D3DQQ9
resolver
uniprot
E9PN48
resolver
uniprot
G5E9L0
resolver
uniprot
Q3LIF2
resolver
uniprot
Q8N3I1
resolver
uniprot
Q96SX7
resolver
uniprot_entry
ARFG2_HUMAN
resolver
uniprot_entry
E9PN48_HUMAN
resolver
uniprot_entry
G5E9L0_HUMAN
resolver
uniprot_sec
B4DX29
resolver
uniprot_sec
B7Z9M7
resolver
uniprot_sec
D3DQQ9
resolver
uniprot_sec
Q3LIF2
resolver
uniprot_sec
Q8N3I1
resolver
uniprot_sec
Q96SX7
resolver
amino_acid_sequence
MAAEPNKTEIQTLFKRLRAVPTNKACFDCGAKNPSWASITYGVFLCIDCSGVHRSLGVHLSFIRSTELDSNWNWFQLRCMQVGGNANATAFFRQHGCTANDANTKYNSRAAQMYREKIRQLGSAALARHGTDLWIDNMSSAVPNHSPEKKDSDFFTEHTQPPAWDAPATEPSGTQQPAPSTESSGLAQPEHGPNTDLLGTSPKASLELKSSIIGKKKPAAAKKGLGAKKGLGAQKVSSQSFSEIERQAQVAEKLREQQAADAKKQAEESMVASMRLAYQELQIDRKKEEKKLQNLEGKKREQAERLGMGLVSRSSVSHSVLSEMQVIEQETPVSAKSSRSQLDLFDDVGTFASGPPKYKDNPFSLGESFGSRWDTDAAWGMDRVEEKEPEVTISSIRPISERATNRREVESRSSGLESSEARQKFAGAKAISSDMFFGREVDAEYEARSRLQQLSGSSAISSSDLFGDMDGAHGAGSVSLGNVLPTADIAQFKQGVKSVAGKMAVLANGVMNSLQDRYGSY
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1), which is essential for COPI vesicle formation and retrograde transport between the Golgi and the endoplasmic reticulum (PubMed:17760859, PubMed:20858901). Hydrolysis of ARF1-bound GTP leads to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (PubMed:20858901). Promotes the proper assembly of the COPI coat lattice, rather than just acting as a simple curvature-dependent GAP like ARFGAP1 (PubMed:20858901). Also acts as a regulator of STING1 activity, both by promoting cytokine secretion in certain cell types and promoting the proton channel activity of STING1 in the trans-Golgi (PubMed:39947179). {ECO:0000269|PubMed:17760859, ECO:0000269|PubMed:20858901, ECO:0000269|PubMed:39947179}.
uniprot
proteins
mass_dalton
56720
uniprot
proteins
pubmed
12880961
uniprot
proteins
pubmed
14690497
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17760859
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20858901
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22375848
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
39947179
uniprot
proteins
sequence_length
521
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:17760859, ECO:0000269|PubMed:20858901, ECO:0000269|PubMed:39947179}; Peripheral membrane protein {ECO:0000269|PubMed:17760859, ECO:0000269|PubMed:20858901}; Cytoplasmic side {ECO:0000269|PubMed:17760859}. Cytoplasm {ECO:0000269|PubMed:17760859}. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment. {ECO:0000269|PubMed:17760859}.
uniprot
proteins