SPIB
entrez
6689
canonical
uniprot
Q01892
canonical
ensembl
ENSG00000269404
resolver
ensp
ENSP00000270632
resolver
ensp
ENSP00000391877
resolver
ensp
ENSP00000471921
resolver
genesymbol
SPIB
resolver
hgnc
HGNC:11242
resolver
uniprot
A8K9C9
resolver
uniprot
B4DUG6
resolver
uniprot
Q15359
resolver
uniprot_entry
SPIB_HUMAN
resolver
uniprot_sec
A8K9C9
resolver
uniprot_sec
B4DUG6
resolver
uniprot_sec
Q15359
resolver
amino_acid_sequence
MLALEAAQLDGPHFSCLYPDGVFYDLDSCKHSSYPDSEGAPDSLWDWTVAPPVPATPYEAFDPAAAAFSHPQAAQLCYEPPTYSPAGNLELAPSLEAPGPGLPAYPTENFASQTLVPPAYAPYPSPVLSEEEDLPLDSPALEVSDSESDEALVAGPEGKGSEAGTRKKLRLYQFLLGLLTRGDMRECVWWVEPGAGVFQFSSKHKELLARRWGQQKGNRKRMTYQKLARALRNYAKTGEIRKVKRKLTYQFDSALLPAVRRA
uniprot
proteins
function
FUNCTION: Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. {ECO:0000269|PubMed:10196196, ECO:0000269|PubMed:12393575, ECO:0000269|PubMed:1406622, ECO:0000269|PubMed:15583020}.
uniprot
proteins
mass_dalton
28819
uniprot
proteins
mutagenesis
MUTAGEN 37; /note="S->A: No effect on transcriptional activation."; /evidence="ECO:0000269|PubMed:10196196"; MUTAGEN 56; /note="T->A: No effect on transcriptional activation."; /evidence="ECO:0000269|PubMed:10196196"; MUTAGEN 144; /note="S->A: Reduces interaction with IRF4 and transcriptional activation."; /evidence="ECO:0000269|PubMed:10196196"; MUTAGEN 242; /note="K->G: Abrogates DNA-binding."; /evidence="ECO:0000269|PubMed:10196196
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
10196196
uniprot
proteins
pubmed
11841448
uniprot
proteins
pubmed
11864910
uniprot
proteins
pubmed
12393575
uniprot
proteins
pubmed
1406622
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15583020
uniprot
proteins
pubmed
8670269
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:12393575}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:12393575}.
uniprot
proteins