SHOC1
entrez
158401
canonical
uniprot
Q5VXU9
canonical
ensembl
ENSG00000165181
resolver
ensp
ENSP00000322108
resolver
ensp
ENSP00000363405
resolver
ensp
ENSP00000378257
resolver
ensp
ENSP00000378259
resolver
ensp
ENSP00000507813
resolver
ensp
ENSP00000508388
resolver
enst
ENST00000394777
resolver
enst
ENST00000682961
resolver
enst
ENST00000683944
resolver
genesymbol
SHOC1
resolver
genesymbol_syn
C9orf84
resolver
genesymbol_syn
ZIP2
resolver
hgnc
HGNC:26535
resolver
uniprot
A0A804HK82
resolver
uniprot
A0A804HLJ8
resolver
uniprot
A2A2V3
resolver
uniprot
A6PVK7
resolver
uniprot
Q2M1H8
resolver
uniprot
Q6ZU10
resolver
uniprot
Q96M73
resolver
uniprot_entry
A0A804HK82_HUMAN
resolver
uniprot_entry
A0A804HLJ8_HUMAN
resolver
uniprot_entry
A6PVK7_HUMAN
resolver
uniprot_entry
Q6ZU10_HUMAN
resolver
uniprot_entry
SHOC1_HUMAN
resolver
uniprot_sec
A2A2V3
resolver
uniprot_sec
Q2M1H8
resolver
uniprot_sec
Q96M73
resolver
amino_acid_sequence
MTDTSVLDQWKASFFVEDFLEKKTITRMVTQINCEFEEVVPSSNPDSQIEVEEVSLYTHMDYNEVFTPVSCLEKCSALQNQNQDLFIDDKGILFVSSRKHLPTLPTLLSRLKLFLVKDPLLDFKGQIFTEANFSRECFSLQETLEAFVKEDFCMDKVNFCQEKLEDTICLNEPSSFLIEYEFLIPPSLKPEIDIPSLSELKELLNPVPEIINYVDEKEKLFERDLTNKHGIEDIGDIKFSSTEILTIQSQSEPEECSKPGELEMPLTPLFLTCQHSSVNSLRTELQTFPLSPVCKINLLTAEESANEYYMMWQLERCRSPLNPFLLTVPRIQEPHSQYSVTDLKKIFSVKEESLVINLEKAEWWKQAGLNLKMMETLEHLNTYLCHDNLSSNDTKIEIFLPTKVLQLESCLEHKSHSSPIALIDEKSTNAHLSLPQKSPSLAKEVPDLCFSDDYFSDKGAAKEEKPKNDQEPVNRIIQKKENNDHFELDCTGPSIKSPSSSIIKKASFEHGKKQENDLDLLSDFIMLRNKYKTCTSKTEVTNSDEKHDKEACSLTLQEESPIVHINKTLEEINQERGTDSVIEIQASDSQCQAFCLLEAAASPILKNLVSLCTLPTANWKFATVIFDQTRFLLKEQEKVVSDAVRQGTIDEREMTFKHAALLHLLVTIRDVLLTCSLDTALGYLSKAKDIYNSILGPYLGDIWRQLEIVQFIRGKKPETNYKIQELQCQILSWMQSQQQIKVLIIIRMDSDGEKHFLIKILNKIEGLTLTVLHSNERKDFLESEGVLRGTSSCVVVHNQYIGADFPWSNFSFVVEYNYVEDSCWTKHCKELNIPYMAFKVILPDTVLERSTLLDRFGGFLLEIQIPYVFFASEGLLNTPDILQLLESNYNISLVERGCSESLKLFGSSECYVVVTIDEHTAIILQDLEELNYEKASDNIIMRLMALSLQYRYCWIILYTKETLNSEYLLTEKTLHHLALIYAALVSFGLNSEELDVKLIIAPGVEATALIIRQIADHSLMTSKRDPHEWLDKSWLKVSPSEEEMYLLDFPCINPLVAQLMLNKGPSLHWILLATLCQLQELLPEVPEKVLKHFCSITSLFKIGSSSITKSPQISSPQENRNQISTLSSQSSASDLDSVIQEHNEYYQYLGLGETVQEDKTTILNDNSSIMELKEISSFLPPVTSYNQTSYWKDSSCKSNIGQNTPFLINIESRRPAYNSFLNHSDSESDVFSLGLTQMNCETIKSPTDTQKRVSVVPRFINSQKRRTHEAKGFINKDVSDPIFSLEGTQSPLHWNFKKNIWEQENHPFNLQYGAQQTACNKLYSQKGNLFTDQQKCLSDESEGLTCESSKDETFWRELPSVPSLDLFRASDSNANQKEFNSLYFYQRAGKSLGQKRHHESSFNSGDKESLTGFMCSQLPQFKKRRLAYEKVPGRVDGQTRLRFF
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 75 (SPGF75) [MIM:619949]: An autosomal recessive disorder characterized by male infertility due to non-obstructive azoospermia resulting from maturation arrest at the spermatocyte stage. {ECO:0000269|PubMed:32741963, ECO:0000269|PubMed:32900840, ECO:0000269|PubMed:35485979}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.6.-.-
uniprot
proteins
function
FUNCTION: ATPase required during meiosis for the formation of crossover recombination intermediates (By similarity). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (PubMed:29742103). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (PubMed:29742103). Plays a key role in homologous recombination and crossing-over in meiotic prophase I in male and female germ cells (By similarity). Required for proper synaptonemal complex assembly and homologous chromosome pairing (By similarity). Requiref for recruitment TEX11 and MSH4 to recombination intermediates (By similarity). {ECO:0000250|UniProtKB:A2ALV5, ECO:0000269|PubMed:29742103}.
uniprot
proteins
mass_dalton
165202
uniprot
proteins
protein_family
XPF family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
29742103
uniprot
proteins
pubmed
32741963
uniprot
proteins
pubmed
32900840
uniprot
proteins
pubmed
35485979
uniprot
proteins
sequence_length
1444
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:A2ALV5}. Note=Localizes to meiotic chromosomes; associates with mid-stage meiotic recombination intermediates. Localization requires meiotic double-strand breaks (DSBs) recombination intermediates catalyzed by DMC1. {ECO:0000250|UniProtKB:A2ALV5}.
uniprot
proteins