Trub1
entrez
361775
canonical
uniprot
Q5M934
canonical
ensembl
ENSRNOG00000017321
resolver
ensembl
ENSRNOG00055028561
resolver
ensembl
ENSRNOG00060021209
resolver
ensembl
ENSRNOG00065010510
resolver
ensp
ENSRNOP00000023309
resolver
ensp
ENSRNOP00055040687
resolver
ensp
ENSRNOP00060030267
resolver
ensp
ENSRNOP00065013045
resolver
enst
ENSRNOT00000023309
resolver
enst
ENSRNOT00055049432
resolver
enst
ENSRNOT00060036757
resolver
enst
ENSRNOT00065017031
resolver
genesymbol
Trub1
resolver
uniprot_entry
TRUB1_RAT
resolver
amino_acid_sequence
MAAEEAEVVSPLIVDTAPDTSGTAAASLAAAVSAAAAAARTGSQAQVSKAALAAKLMSLSGVFAVHKPKGPTSAELLNRLKEKLLAEAGLPSPEWNKRQKQTLKVGHGGTLDSAAQGVLVVGIGRGTKMLTSMLSGSKRYIATGELGKATDTLDSTGKVTEEKPYDKITQEDIEGILQKFTGNIMQVPPLYSALKKDGQRLSTLMKRGETVEARPARPVTVHSISLLKYQPPFFTLDVECGGGFYIRSLVSDIGKELSSCATVLELTRTKQGPFTLAQHALPEDRWTINDIAQSLKRCTSLLPEELTFKKSKSEPSSDQALSCGYITLRETKREDDTVKTL
uniprot
proteins
ec_number
5.4.99.-
uniprot
proteins
ec_number
5.4.99.25
uniprot
proteins
function
FUNCTION: Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity. Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation. {ECO:0000250|UniProtKB:Q8WWH5}.
uniprot
proteins
mass_dalton
36404
uniprot
proteins
protein_family
Pseudouridine synthase TruB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
341
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WWH5}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8WWH5}. Note=Catalyzes pseudouridylation of mRNAs in the nucleus. {ECO:0000250|UniProtKB:Q8WWH5}.
uniprot
proteins