Arg2
entrez
29215
canonical
uniprot
O08701
canonical
ensembl
ENSRNOG00000053811
resolver
ensp
ENSRNOP00000073568
resolver
enst
ENSRNOT00000083433
resolver
genesymbol
Arg2
resolver
uniprot
G3V7H6
resolver
uniprot
P97539
resolver
uniprot_entry
ARGI2_RAT
resolver
uniprot_entry
G3V7H6_RAT
resolver
uniprot_sec
P97539
resolver
amino_acid_sequence
MFLRSSVSRLLHGQIPCALTRSVHSVAVVGAPFSRGQKKKGVEYGPAAIREAGLLKRLSMLGCHIKDFGDLSFTNVPKDDPYNNLVVYPRSVGIANQELAEVVSRAVSGGYSCVTLGGDHSLAIGTISGHARHHPDLCVIWVDAHADINTPLTTVSGNIHGQPLSFLIRELQDKVPQLPGFSWIKPCLSPPNLVYIGLRDVEPAEHFILKSFDIQYFSMRDIDRLGIQKVMEQTFDRLIGKRKRPIHLSFDIDAFDPKLAPATGTPVVGGLTYREGLYITEEIHSTGLLSALDLVEVNPHLATSEEEAKATASLAVDVIASSFGQTREGGHIAYDHLPTPSSPHESEKEECVRI
uniprot
proteins
ec_number
3.5.3.1
uniprot
proteins
function
FUNCTION: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity. {ECO:0000250|UniProtKB:O08691, ECO:0000250|UniProtKB:P78540}.
uniprot
proteins
mass_dalton
38640
uniprot
proteins
pathway_participation
PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. {ECO:0000250|UniProtKB:P05089}.
uniprot
proteins
protein_family
Arginase family
uniprot
proteins
pubmed
8898077
uniprot
proteins
pubmed
9608538
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:O08691, ECO:0000250|UniProtKB:P78540}.
uniprot
proteins