Sigirr
entrez
24058
canonical
uniprot
Q9JLZ8
canonical
ensembl
ENSMUSG00000025494
resolver
ensp
ENSMUSP00000095571
resolver
ensp
ENSMUSP00000147541
resolver
ensp
ENSMUSP00000210224
resolver
ensp
ENSMUSP00000210226
resolver
ensp
ENSMUSP00000210232
resolver
ensp
ENSMUSP00000328002
resolver
genesymbol
Sigirr
resolver
genesymbol_syn
AI256711
resolver
genesymbol_syn
Tir8
resolver
uniprot
Q3UKS3
resolver
uniprot
Q52L48
resolver
uniprot_entry
Q3UKS3_MOUSE
resolver
uniprot_entry
SIGIR_MOUSE
resolver
uniprot_sec
Q52L48
resolver
amino_acid_sequence
MAGVCDMAPNFLSPSEDQALGLALGREVALNCTAWVFSRPQCPQPSVQWLKDGLALGNGSHFSLHEDFWVSANFSEIVSSVLVLNLTNAEDYGTFTCSVWNVSSHSFTLWRAGPAGHVAAVLASLLVLVVLLLVALLYVKCRLNMLLWYQDTYGEVEMNDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLEDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRPWCSQSFREGLCRLLELTRRPIFITFEGQRREPIHPALRLLRQHRHLVTLVLWKPGSVTPSSDFWKELQLALPRKVQYRPVEGDPQTRLQDDKDPMLIVRGRAAQGRGMESELDPDPEGDLGVRGPVFGEPPTPLQETRICIGESHGSEMDVSDLGSRNYSARTDFYCLVSEDDV
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity). {ECO:0000250, ECO:0000269|PubMed:12925853}.
uniprot
proteins
mass_dalton
46159
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
10346978
uniprot
proteins
pubmed
12925853
uniprot
proteins
pubmed
14993616
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21077278
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
409
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 118..138; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins