Il17rd
entrez
171463
canonical
uniprot
Q8JZL1
canonical
ensembl
ENSMUSG00000040717
resolver
ensp
ENSMUSP00000036076
resolver
ensp
ENSMUSP00000153543
resolver
ensp
ENSMUSP00000341035
resolver
genesymbol
Il17rd
resolver
genesymbol_syn
Il17rlm
resolver
genesymbol_syn
Sef
resolver
uniprot
B2RRY7
resolver
uniprot
Q8K447
resolver
uniprot
Q8R5J8
resolver
uniprot_entry
I17RD_MOUSE
resolver
uniprot_sec
B2RRY7
resolver
uniprot_sec
Q8K447
resolver
uniprot_sec
Q8R5J8
resolver
amino_acid_sequence
MAPWLQLCSFFFTVNACLNGSQLAVAAGGSGRARGADTCGWRGVGPASRNSGLHNITFRYDNCTTYLNPGGKHAIADAQNITISQYACHDQVAVTILWSPGALGIEFLKGFRVILEELKSEGRQCQQLILKDPKQLNSSFRRTGMESQPFLNMKFETDYFVKIVPFPSIKNESNYHPFFFRTRACDLLLQPDNLACKPFWKPRNLNISQHGSDMHVSFDHAPQNFGFRGFHVLYKLKHEGPFRRRTCRQDQNTETTSCLLQNVSPGDYIIELVDDSNTTRKAAQYVVKSVQSPWAGPIRAVAITVPLVVISAFATLFTVMCRKKQQENIYSHLDEESPESSTYAAALPRDRLRPQPKVFLCYSNKDGQNHMNVVQCFAYFLQDFCGCEVALDLWEDFSLCREGQREWAIQKIHESQFIIVVCSKGMKYFVDKKNFRHKGGSRGEAQGEFFLVAVAAIAEKLRQAKQSSSAALRKFIAVYFDYSCEGDVPCSLDLSTKYKLMDHLPELCAHLHSGEQEVLGQHPGHSSRRNYFRSKSGRSLYVAICNMHQFIDEEPDWFEKQFIPFQHPPVRYQEPVLEKFDSGLVLNDVISKPGPESDFCRKVEACVLGAAGPADSYSYLESQHVGLDQDTEAQPSCDSAPALQPLLHAVKAGSPSEMPRDSGIYDSSVPSSELSLPLMEGLSPDQIETSSLTESVSSSSGLGEEDPPTLPSKLLASGVSREHGCHSHTDELQALAPL
uniprot
proteins
function
FUNCTION: Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation (PubMed:12604616). Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK (By similarity). Mediates JNK activation and may be involved in apoptosis (PubMed:15277532). May inhibit FGF-induced FGFR1 tyrosine phosphorylation (PubMed:12604616). Might have a role in the early stages of fate specification of GnRH-secreting neurons (PubMed:23643382). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (PubMed:25576668). {ECO:0000250|UniProtKB:Q8NFM7, ECO:0000269|PubMed:12604616, ECO:0000269|PubMed:15277532, ECO:0000269|PubMed:23643382, ECO:0000269|PubMed:25576668}.
uniprot
proteins
mass_dalton
82348
uniprot
proteins
pubmed
11960706
uniprot
proteins
pubmed
12604616
uniprot
proteins
pubmed
12958313
uniprot
proteins
pubmed
15277532
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23643382
uniprot
proteins
pubmed
25576668
uniprot
proteins
sequence_length
738
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 300..320; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins