NTMT1
entrez
28989
canonical
uniprot
Q9BV86
canonical
ensembl
ENSG00000148335
resolver
ensp
ENSP00000361558
resolver
ensp
ENSP00000361559
resolver
ensp
ENSP00000361561
resolver
ensp
ENSP00000361564
resolver
ensp
ENSP00000473900
resolver
ensp
ENSP00000478521
resolver
ensp
ENSP00000483489
resolver
ensp
ENSP00000484447
resolver
ensp
ENSP00000619757
resolver
ensp
ENSP00000619758
resolver
ensp
ENSP00000649975
resolver
ensp
ENSP00000694352
resolver
ensp
ENSP00000694356
resolver
enst
ENST00000482347
resolver
enst
ENST00000617943
resolver
genesymbol
NTMT1
resolver
genesymbol_syn
C9orf32
resolver
genesymbol_syn
METTL11A
resolver
genesymbol_syn
NRMT
resolver
genesymbol_syn
NRMT1
resolver
hgnc
HGNC:23373
resolver
uniprot
A8K4J2
resolver
uniprot
A8K8G7
resolver
uniprot
Q5SZB9
resolver
uniprot
Q9UI28
resolver
uniprot
S4R338
resolver
uniprot_entry
NTM1A_HUMAN
resolver
uniprot_entry
S4R338_HUMAN
resolver
uniprot_sec
A8K4J2
resolver
uniprot_sec
A8K8G7
resolver
uniprot_sec
Q5SZB9
resolver
uniprot_sec
Q9UI28
resolver
amino_acid_sequence
MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDINSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFREVDMVDITEDFLVQAKTYLGEEGKRVRNYFCCGLQDFTPEPDSYDVIWIQWVIGHLTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLDVVRRIICSAGLSLLAEERQENLPDEIYHVYSFALR
uniprot
proteins
ec_number
2.1.1.244
uniprot
proteins
function
FUNCTION: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. {ECO:0000269|PubMed:20481588, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:24090352, ECO:0000269|PubMed:26543159}.
uniprot
proteins
mass_dalton
25387
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="Y->A,F: Decreased methyltransferase activity with CENPA."; /evidence="ECO:0000269|PubMed:26543159"; MUTAGEN 19; /note="Y->A: Reduced methyltransferase activity with CENPA."; /evidence="ECO:0000269|PubMed:26543159"; MUTAGEN 20; /note="W->A,M,Y: Nearly abolishes methyltransferase activity with CENPA."; /evidence="ECO:0000269|PubMed:26543159"; MUTAGEN 136; /note="W->L: Strongly reduces methyltransferase activity with CENPA."; /evidence="ECO:0000269|PubMed:26543159"; MUTAGEN 167; /note="D->A: Does not affect methyltransferase activity."; /evidence="ECO:0000269|PubMed:20668449"; MUTAGEN 167; /note="D->N,Q: Abolishes methyltransferase activity with CENPA."; /evidence="ECO:0000269|PubMed:26543159"; MUTAGEN 168; /note="N->A: Decreased methyltransferase activity."; /evidence="ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:26543159"; MUTAGEN 168; /note="N->K: Loss of methyltransferase activity."; /evidence="ECO:0000269|PubMed:20668449"; MUTAGEN 177; /note="D->A: Induces a slight decrease in methyltransferase activity."; /evidence="ECO:0000269|PubMed:20668449"; MUTAGEN 177; /note="D->K: Induces a strong decrease in methyltransferase activity."; /evidence="ECO:0000269|PubMed:20668449"; MUTAGEN 177; /note="D->N: Strongly reduces methyltransferase activity with CENPA."; /evidence="ECO:0000269|PubMed:26543159"; MUTAGEN 180; /note="D->A: Induces a decrease in methyltransferase activity."; /evidence="ECO:0000269|PubMed:20668449"; MUTAGEN 180; /note="D->K: Induces a strong decrease in methyltransferase activity."; /evidence="ECO:0000269|PubMed:20668449"; MUTAGEN 180; /note="D->N: Reduced methyltransferase activity with CENPA."; /evidence="ECO:0000269|PubMed:26543159"; MUTAGEN 182; /note="S->A: Induces a slight decrease in methyltransferase activity."; /evidence="ECO:0000269|PubMed:20668449"; MUTAGEN 182; /note="S->K: Induces a strong decrease in methyltransferase activity."; /evidence="ECO:0000269|PubMed:20668449
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
protein_family
NTM1 family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20481588
uniprot
proteins
pubmed
20668449
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
24090352
uniprot
proteins
pubmed
26543159
uniprot
proteins
pubmed
26543161
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:24090352}. Note=Predominantly nuclear (PubMed:24090352).
uniprot
proteins