AP1AR
entrez
55435
canonical
uniprot
Q63HQ0
canonical
ensembl
ENSG00000138660
resolver
ensp
ENSP00000274000
resolver
ensp
ENSP00000309023
resolver
genesymbol
AP1AR
resolver
genesymbol_syn
C4orf16
resolver
hgnc
HGNC:28808
resolver
uniprot
B2RCV7
resolver
uniprot
Q96GG6
resolver
uniprot
Q9H0V0
resolver
uniprot
Q9P1L4
resolver
uniprot_entry
AP1AR_HUMAN
resolver
uniprot_sec
B2RCV7
resolver
uniprot_sec
Q96GG6
resolver
uniprot_sec
Q9H0V0
resolver
uniprot_sec
Q9P1L4
resolver
amino_acid_sequence
MGNCCWTQCFGLLRKEAGRLQRVGGGGGSKYFRTCSRGEHLTIEFENLVESDEGESPGSSHRPLTEEEIVDLRERHYDSIAEKQKDLDKKIQKELALQEEKLRLEEEALYAAQREAARAAKQRKLLEQERQRIVQQYHPSNNGEYQSSGPEDDFESCLRNMKSQYEVFRSSRLSSDATVLTPNTESSCDLMTKTKSTSGNDDSTSLDLEWEDEEGMNRMLPMRERSKTEEDILRAALKYSNKKTGSNPTSASDDSNGLEWENDFVSAEMDDNGNSEYSGFVNPVLELSDSGIRHSDTDQQTR
uniprot
proteins
function
FUNCTION: Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984, ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240, ECO:0000269|PubMed:22689987}.
uniprot
proteins
mass_dalton
34280
uniprot
proteins
mutagenesis
MUTAGEN 4..5; /note="CC->SS: Loss of association with membranes, no effect on interaction with AP1G1; when associated with 9-S."; /evidence="ECO:0000269|PubMed:19965873"; MUTAGEN 9; /note="C->S: Loss of association with membranes, no effect on interaction with AP1G1; when associated with 4-S-S-5."; /evidence="ECO:0000269|PubMed:19965873"; MUTAGEN 210; /note="W->A: Loss of association with the Arp2/3 complex and endosomal colocalization. Abolishes interaction with KLC2, no effect on interaction with AP1G1."; /evidence="ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:22689987"; MUTAGEN 260; /note="W->L: Decreases interaction with AP1G1; when associated with L-264."; /evidence="ECO:0000269|PubMed:19965873"; MUTAGEN 264; /note="F->L: Decreases interaction with AP1G1; when associated with L-260."; /evidence="ECO:0000269|PubMed:19965873
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. {ECO:0000269|PubMed:19965873}.
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15775984
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19706427
uniprot
proteins
pubmed
19965873
uniprot
proteins
pubmed
21525240
uniprot
proteins
pubmed
22689987
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
302
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network. Late endosome. Early endosome. Note=Localizes to the juxta-nuclear Golgi region and to tubular structures throughout the cytoplasm, which are highly mobile and cycle between the juxta-nuclear area and the cell periphery.
uniprot
proteins