SESN1
entrez
27244
canonical
uniprot
Q9Y6P5
canonical
ensembl
ENSG00000080546
resolver
ensp
ENSP00000306734
resolver
ensp
ENSP00000349061
resolver
ensp
ENSP00000393762
resolver
genesymbol
SESN1
resolver
genesymbol_syn
PA26
resolver
genesymbol_syn
SEST1
resolver
hgnc
HGNC:21595
resolver
uniprot
Q2M2B7
resolver
uniprot
Q5T316
resolver
uniprot
Q9NV00
resolver
uniprot
Q9UPD5
resolver
uniprot
Q9Y6P6
resolver
uniprot_entry
SESN1_HUMAN
resolver
uniprot_sec
Q2M2B7
resolver
uniprot_sec
Q5T316
resolver
uniprot_sec
Q9NV00
resolver
uniprot_sec
Q9UPD5
resolver
uniprot_sec
Q9Y6P6
resolver
amino_acid_sequence
MRLAAAANEAYTAPLAVSGLLGCKQCGGGRDQDEELGIRIPRPLGQGPSRFIPEKEILQVGSEDAQMHALFADSFAALGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYIGIMAAARHQCSYLVNLHVNDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSWSLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEMPVNSAENVSVSDSFFEVEALMEKMRQLQECRDEEEASQEEMASRFEIEKRESMFVFSSDDEEVTPARAVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
function
FUNCTION: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity). {ECO:0000250|UniProtKB:P58004, ECO:0000269|PubMed:15105503, ECO:0000269|PubMed:23274085, ECO:0000269|PubMed:25263562, ECO:0000269|PubMed:26449471}.
uniprot
proteins
mass_dalton
56557
uniprot
proteins
mutagenesis
MUTAGEN 130; /note="C->S: Loss of the ability to decrease intracellular reactive oxygen species."; /evidence="ECO:0000269|PubMed:15105503
uniprot
proteins
protein_family
Sestrin family
uniprot
proteins
pubmed
12607115
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15105503
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23274085
uniprot
proteins
pubmed
25259925
uniprot
proteins
pubmed
25263562
uniprot
proteins
pubmed
26449471
uniprot
proteins
pubmed
9926927
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9926927}. Cytoplasm {ECO:0000269|PubMed:15105503}.
uniprot
proteins