Slc1a4
entrez
55963
canonical
uniprot
O35874
canonical
ensembl
ENSMUSG00000020142
resolver
ensp
ENSMUSP00000105223
resolver
enst
ENSMUST00000109594
resolver
genesymbol
Slc1a4
resolver
genesymbol_syn
Asct1
resolver
genesymbol_syn
Satt
resolver
uniprot
Q3US35
resolver
uniprot
Q3UTP8
resolver
uniprot_entry
Q3US35_MOUSE
resolver
uniprot_entry
Q3UTP8_MOUSE
resolver
uniprot_entry
SATT_MOUSE
resolver
amino_acid_sequence
MEKSGETNGYLDGTQAEPAAGPRTPETAMGKSQRCASFFRRHALVLLTVSGVLVGAGMGAALRGLQLTRTQITYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASSLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGAGAQTLQSSSLGLENSGPPPVSKETVDSFLDLLRNLFPSNLVVAAFTTSATDYTVVTHNTSSGNVTKEKIPVVTDVEGMNILGLVLFALVLGVALKKLGPEGEDLIRFFNSFNEATMVLVSWIMWYVPIGIMFLIGSKIVEMKDIVMLVTSLGKYIFASMLGHVIHGGIVLPLVYFAFTRKNPFTFLLGLLTPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVDLNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLSLILAVDWIVDRTTTVVNVEGDALGAGILNHLNQKVVKKGEQELQEVKVEAIPNSKSEEETSPLVTHQNPAGPVAIAPELESKESVL
uniprot
proteins
function
FUNCTION: Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (By similarity) (PubMed:30185558). Exchanges neutral amino acids such as L- and D-serine, L-threonine, L-asparagine and L-alanine in a bidirectional way (By similarity) (PubMed:30185558). Involved in homeostasis of D-serine, a coagonist of synaptic NMDA receptors. In astrocytes at excitatory synapses, mediates electrogenic D-serine influx coupled to L-serine efflux and L-serine shuttling to neurons for de novo D-serine synthesis (PubMed:30185558, PubMed:37238689). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) > NO3(-) > I(-) > Cl(-) (By similarity). {ECO:0000250|UniProtKB:P43007, ECO:0000269|PubMed:30185558, ECO:0000269|PubMed:37238689}.
uniprot
proteins
mass_dalton
56062
uniprot
proteins
protein_family
Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family
uniprot
proteins
protein_family
SLC1A4 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30185558
uniprot
proteins
pubmed
35195906
uniprot
proteins
pubmed
37238689
uniprot
proteins
sequence_length
532
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P43007}; Multi-pass membrane protein {ECO:0000255}. Melanosome membrane {ECO:0000250|UniProtKB:P43007}; Multi-pass membrane protein {ECO:0000255}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250|UniProtKB:P43007}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..67; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P43007, ECO:0000250|UniProtKB:Q15758"; TRANSMEM 81..102; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P43007, ECO:0000250|UniProtKB:Q15758"; TRANSMEM 117..139; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P43007, ECO:0000250|UniProtKB:Q15758"; TRANSMEM 217..240; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P43007, ECO:0000250|UniProtKB:Q15758"; TRANSMEM 250..277; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P43007, ECO:0000250|UniProtKB:Q15758"; TRANSMEM 299..320; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P43007, ECO:0000250|UniProtKB:Q15758"; TRANSMEM 366..392; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P43007, ECO:0000250|UniProtKB:Q15758"; TRANSMEM 453..474; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P43007, ECO:0000250|UniProtKB:Q15758
uniprot
proteins