LILRB1
entrez
10859
canonical
uniprot
Q8NHL6
canonical
ensembl
ENSG00000104972
resolver
ensembl
ENSG00000274669
resolver
ensembl
ENSG00000277134
resolver
ensembl
ENSG00000277807
resolver
ensp
ENSP00000315997
resolver
ensp
ENSP00000379608
resolver
ensp
ENSP00000379610
resolver
ensp
ENSP00000379618
resolver
ensp
ENSP00000379622
resolver
ensp
ENSP00000379623
resolver
ensp
ENSP00000410165
resolver
ensp
ENSP00000481700
resolver
ensp
ENSP00000481701
resolver
ensp
ENSP00000482978
resolver
ensp
ENSP00000484746
resolver
ensp
ENSP00000560853
resolver
ensp
ENSP00000560854
resolver
ensp
ENSP00000560855
resolver
ensp
ENSP00000560856
resolver
ensp
ENSP00000560857
resolver
ensp
ENSP00000560859
resolver
ensp
ENSP00000560861
resolver
ensp
ENSP00000560862
resolver
ensp
ENSP00000625196
resolver
ensp
ENSP00000625198
resolver
ensp
ENSP00000692014
resolver
ensp
ENSP00000692015
resolver
enst
ENST00000324602
resolver
enst
ENST00000396315
resolver
enst
ENST00000396317
resolver
enst
ENST00000396327
resolver
enst
ENST00000396331
resolver
enst
ENST00000396332
resolver
enst
ENST00000610641
resolver
enst
ENST00000611295
resolver
enst
ENST00000615841
resolver
enst
ENST00000616408
resolver
enst
ENST00000890794
resolver
enst
ENST00000890795
resolver
enst
ENST00000890796
resolver
enst
ENST00000890797
resolver
enst
ENST00000890798
resolver
enst
ENST00000890800
resolver
enst
ENST00000890802
resolver
enst
ENST00000890803
resolver
enst
ENST00000955139
resolver
genesymbol
LILRB1
resolver
genesymbol_syn
ILT2
resolver
genesymbol_syn
LIR1
resolver
genesymbol_syn
MIR7
resolver
hgnc
HGNC:6605
resolver
uniprot
A0A087WSV6
resolver
uniprot
A0A087WSX8
resolver
uniprot
A0A0B4J1W1
resolver
uniprot
A0A0G2JNM2
resolver
uniprot
A0A0G2JP64
resolver
uniprot
A0A0G2JQ15
resolver
uniprot
A2IXV4
resolver
uniprot
A8MVE2
resolver
uniprot
A8MXT0
resolver
uniprot
D9IDM5
resolver
uniprot
O75024
resolver
uniprot
O75025
resolver
uniprot
Q8NHJ9
resolver
uniprot
Q8NHK0
resolver
uniprot_entry
A0A087WSV6_HUMAN
resolver
uniprot_entry
A0A087WSX8_HUMAN
resolver
uniprot_entry
A0A0B4J1W1_HUMAN
resolver
uniprot_entry
A0A0G2JNM2_HUMAN
resolver
uniprot_entry
A0A0G2JP64_HUMAN
resolver
uniprot_entry
A0A0G2JQ15_HUMAN
resolver
uniprot_entry
A8MVE2_HUMAN
resolver
uniprot_entry
D9IDM5_HUMAN
resolver
uniprot_entry
LIRB1_HUMAN
resolver
uniprot_sec
A2IXV4
resolver
uniprot_sec
A8MXT0
resolver
uniprot_sec
O75024
resolver
uniprot_sec
O75025
resolver
uniprot_sec
Q8NHJ9
resolver
uniprot_sec
Q8NHK0
resolver
amino_acid_sequence
MTPILTVLICLGLSLGPRTHVQAGHLPKPTLWAEPGSVITQGSPVTLRCQGGQETQEYRLYREKKTALWITRIPQELVKKGQFPIPSITWEHAGRYRCYYGSDTAGRSESSDPLELVVTGAYIKPTLSAQPSPVVNSGGNVILQCDSQVAFDGFSLCKEGEDEHPQCLNSQPHARGSSRAIFSVGPVSPSRRWWYRCYAYDSNSPYEWSLPSDLLELLVLGVSKKPSLSVQPGPIVAPEETLTLQCGSDAGYNRFVLYKDGERDFLQLAGAQPQAGLSQANFTLGPVSRSYGGQYRCYGAHNLSSEWSAPSDPLDILIAGQFYDRVSLSVQPGPTVASGENVTLLCQSQGWMQTFLLTKEGAADDPWRLRSTYQSQKYQAEFPMGPVTSAHAGTYRCYGSQSSKPYLLTHPSDPLELVVSGPSGGPSSPTTGPTSTSGPEDQPLTPTGSDPQSGLGRHLGVVIGILVAVILLLLLLLLLFLILRHRRQGKHWTSTQRKADFQHPAGAVGPEPTDRGLQWRSSPAADAQEENLYAAVKHTQPEDGVEMDTRSPHDEDPQAVTYAEVKHSRPRREMASPPSPLSGEFLDTKDRQAEEDRQMDTEAAASEAPQDVTYAQLHSLTLRREATEPPPSQEGPSPAVPSIYATLAIH
uniprot
proteins
function
FUNCTION: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:19304799, PubMed:29262349). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251). {ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:16455647, ECO:0000269|PubMed:19304799, ECO:0000269|PubMed:24453251, ECO:0000269|PubMed:28636952, ECO:0000269|PubMed:29262349, ECO:0000269|PubMed:9285411, ECO:0000269|PubMed:9842885}.
uniprot
proteins
mass_dalton
70819
uniprot
proteins
mutagenesis
MUTAGEN 533; /note="Y->F: Impairs receptor phosphorylation and abolishes inhibition of serotonin release. No effect on PTPN6 binding; when associated with F-562."; /evidence="ECO:0000269|PubMed:11907092"; MUTAGEN 562; /note="Y->F: No effect on PTPN6 binding; when associated with F-533."; /evidence="ECO:0000269|PubMed:11907092"; MUTAGEN 614; /note="Y->F: No effect on PTPN6 binding. Abolishes PTPN6 binding; when associated with F-644."; /evidence="ECO:0000269|PubMed:11907092"; MUTAGEN 644; /note="Y->F: Reduces PTPN6 binding. Abolishes PTPN6 binding; when associated with F-614."; /evidence="ECO:0000269|PubMed:11907092
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. {ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:9285411, ECO:0000269|PubMed:9842885}.
uniprot
proteins
pubmed
10591185
uniprot
proteins
pubmed
10941837
uniprot
proteins
pubmed
11114384
uniprot
proteins
pubmed
11907092
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16455647
uniprot
proteins
pubmed
19304799
uniprot
proteins
pubmed
19658091
uniprot
proteins
pubmed
20448110
uniprot
proteins
pubmed
20600445
uniprot
proteins
pubmed
24453251
uniprot
proteins
pubmed
28636952
uniprot
proteins
pubmed
29262349
uniprot
proteins
pubmed
9259559
uniprot
proteins
pubmed
9285411
uniprot
proteins
pubmed
9842885
uniprot
proteins
sequence_length
650
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:24453251, ECO:0000269|PubMed:29262349, ECO:0000305|PubMed:19658091}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted {ECO:0000269|PubMed:19658091}.
uniprot
proteins
transmembrane_region
TRANSMEM 462..482; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins