SLCO1C1
entrez
53919
canonical
uniprot
Q9NYB5
canonical
ensembl
ENSG00000139155
resolver
ensp
ENSP00000266509
resolver
ensp
ENSP00000438665
resolver
ensp
ENSP00000444149
resolver
ensp
ENSP00000444527
resolver
genesymbol
SLCO1C1
resolver
genesymbol_syn
OATP14
resolver
genesymbol_syn
OATP1C1
resolver
genesymbol_syn
OATPF
resolver
genesymbol_syn
SLC21A14
resolver
hgnc
HGNC:13819
resolver
uniprot
B7Z251
resolver
uniprot
B7Z3Q3
resolver
uniprot
B7Z8P1
resolver
uniprot
F5GZD6
resolver
uniprot
Q5JPA4
resolver
uniprot_entry
SO1C1_HUMAN
resolver
uniprot_sec
B7Z251
resolver
uniprot_sec
B7Z3Q3
resolver
uniprot_sec
B7Z8P1
resolver
uniprot_sec
F5GZD6
resolver
uniprot_sec
Q5JPA4
resolver
activity_regulation
ACTIVITY REGULATION: Estrone 3-glucuronide allosterically inhibits estrone 3-sulfate uptake. {ECO:0000269|PubMed:40680733}.
uniprot
proteins
amino_acid_sequence
MDTSSKENIQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYSPSSNSTLSISPCLLESSSQLPVSVMEKSKSKISNECEVDTSSSMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRSQSREDSNSSSEKSKFIIDDHTDYQTPQGENAKIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVFRHIYLGLTVILGTVSILLSIAVLFILKKNYVSKHRSFITKRERTMVSTRFQKENYTTSDHLLQPNYWPGKETQL
uniprot
proteins
function
FUNCTION: Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane (PubMed:12351693, PubMed:18566113, PubMed:19129463, PubMed:40680733). Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases (PubMed:18566113). Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases (PubMed:18566113). Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency (PubMed:12351693, PubMed:19129463, PubMed:40680733). Transports T4 and E1S in a pH-insensitive manner (PubMed:19129463). Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain (PubMed:30296914). {ECO:0000269|PubMed:12351693, ECO:0000269|PubMed:18566113, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:30296914, ECO:0000269|PubMed:40680733}.
uniprot
proteins
mass_dalton
78696
uniprot
proteins
mutagenesis
MUTAGEN 73; /note="R->A,F,W: Significantly decreased localization to the cell membrane."; /evidence="ECO:0000269|PubMed:40680733"; MUTAGEN 74; /note="F->A,W: Significantly decreased localization to the cell membrane."; /evidence="ECO:0000269|PubMed:40680733"; MUTAGEN 130; /note="Q->E: Significantly decreased localization to the cell membrane."; /evidence="ECO:0000269|PubMed:40680733"; MUTAGEN 130; /note="Q->H: Gain of pH-sensitivity of E1S transport."; /evidence="ECO:0000269|PubMed:19129463"; MUTAGEN 187; /note="W->A: Decreased localization to the cell membrane."; /evidence="ECO:0000269|PubMed:40680733"; MUTAGEN 240; /note="F->A: Does not affect localization to the cell membrane. Loss of L-thyroxine uptake."; /evidence="ECO:0000269|PubMed:40680733"; MUTAGEN 252; /note="D->E: Decreased localization to the cell membrane."; /evidence="ECO:0000269|PubMed:40680733"; MUTAGEN 376; /note="K->A: Does not affect localization to the cell membrane. Loss of L-thyroxine and estrone-3-sulfate uptake."; /evidence="ECO:0000269|PubMed:40680733"; MUTAGEN 399; /note="N->A: Decreased localization to the cell membrane. Significant reduction in L-thyroxine uptake. Loss of estrone-3-sulfate uptake."; /evidence="ECO:0000269|PubMed:40680733"; MUTAGEN 562; /note="S->A: Decreased localization to the cell membrane. Moderate effect on L-thyroxine uptake. Loss of estrone-3-sulfate uptake."; /evidence="ECO:0000269|PubMed:40680733
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
12351693
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18566113
uniprot
proteins
pubmed
18687783
uniprot
proteins
pubmed
19129463
uniprot
proteins
pubmed
30296914
uniprot
proteins
pubmed
35307651
uniprot
proteins
pubmed
40680733
uniprot
proteins
sequence_length
712
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12351693, ECO:0000269|PubMed:18687783, ECO:0000269|PubMed:40680733}; Multi-pass membrane protein {ECO:0000269|PubMed:18687783}. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus. {ECO:0000269|PubMed:18687783}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..63; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:40680733"; TRANSMEM 83..103; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:40680733"; TRANSMEM 110..134; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:40680733"; TRANSMEM 185..213; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:40680733"; TRANSMEM 233..253; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:40680733"; TRANSMEM 272..296; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:40680733"; TRANSMEM 349..370; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:40680733"; TRANSMEM 391..414; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:40680733"; TRANSMEM 419..442; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:40680733"; TRANSMEM 555..577; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:40680733"; TRANSMEM 587..612; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:40680733"; TRANSMEM 647..664; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:40680733
uniprot
proteins