CCNE1
entrez
898
canonical
uniprot
P24864
canonical
ensembl
ENSG00000105173
resolver
ensp
ENSP00000262643
resolver
ensp
ENSP00000350625
resolver
ensp
ENSP00000410179
resolver
ensp
ENSP00000526027
resolver
ensp
ENSP00000607564
resolver
enst
ENST00000357943
resolver
genesymbol
CCNE1
resolver
genesymbol
pCCNE1
resolver
genesymbol_syn
CCNE
resolver
hgnc
HGNC:1589
resolver
uniprot
A0A0G3DHS8
resolver
uniprot
A0ACM8QJS9
resolver
uniprot
A8K684
resolver
uniprot
C9J2U0
resolver
uniprot
Q14091
resolver
uniprot
Q8NFG1
resolver
uniprot
Q92501
resolver
uniprot
Q9UD21
resolver
uniprot
V5W5X2
resolver
uniprot
V5W643
resolver
uniprot_entry
A0A0G3DHS8_HUMAN
resolver
uniprot_entry
A0ACM8QJS9_HUMAN
resolver
uniprot_entry
C9J2U0_HUMAN
resolver
uniprot_entry
CCNE1_HUMAN
resolver
uniprot_entry
V5W5X2_HUMAN
resolver
uniprot_sec
A8K684
resolver
uniprot_sec
Q14091
resolver
uniprot_sec
Q8NFG1
resolver
uniprot_sec
Q92501
resolver
uniprot_sec
Q9UD21
resolver
uniprot_sec
V5W643
resolver
amino_acid_sequence
MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA
uniprot
proteins
function
FUNCTION: Essential for the control of the cell cycle at the G1/S (start) transition. {ECO:0000269|PubMed:7739542}.
uniprot
proteins
mass_dalton
47077
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7. {ECO:0000269|PubMed:14536078, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:21952639, ECO:0000269|PubMed:8861947}.; PTM: Ubiquitinated by UHRF2; appears to occur independently of phosphorylation. {ECO:0000269|PubMed:21952639}.
uniprot
proteins
protein_family
Cyclin E subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
14536078
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15178429
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15660127
uniprot
proteins
pubmed
17434132
uniprot
proteins
pubmed
1833066
uniprot
proteins
pubmed
1833068
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
21540187
uniprot
proteins
pubmed
21952639
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
7739542
uniprot
proteins
pubmed
8207080
uniprot
proteins
pubmed
8649818
uniprot
proteins
pubmed
8833152
uniprot
proteins
pubmed
8861947
uniprot
proteins
pubmed
9840943
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7739542}.
uniprot
proteins