TMSB4X
entrez
7114
canonical
uniprot
P62328
canonical
ensembl
ENSG00000205542
resolver
ensp
ENSP00000370007
resolver
ensp
ENSP00000370009
resolver
ensp
ENSP00000370010
resolver
ensp
ENSP00000414376
resolver
ensp
ENSP00000546218
resolver
ensp
ENSP00000546219
resolver
ensp
ENSP00000546220
resolver
ensp
ENSP00000601371
resolver
ensp
ENSP00000601372
resolver
ensp
ENSP00000601373
resolver
ensp
ENSP00000601374
resolver
ensp
ENSP00000601375
resolver
enst
ENST00000380633
resolver
enst
ENST00000380635
resolver
enst
ENST00000380636
resolver
enst
ENST00000451311
resolver
enst
ENST00000876159
resolver
enst
ENST00000876160
resolver
enst
ENST00000876161
resolver
enst
ENST00000931312
resolver
enst
ENST00000931313
resolver
enst
ENST00000931314
resolver
enst
ENST00000931315
resolver
enst
ENST00000931316
resolver
genesymbol
TMSB4X
resolver
genesymbol_syn
TB4X
resolver
genesymbol_syn
THYB4
resolver
genesymbol_syn
TMSB4
resolver
hgnc
HGNC:11881
resolver
uniprot
A2VCK8
resolver
uniprot
P01253
resolver
uniprot
P01254
resolver
uniprot
Q0P5T0
resolver
uniprot
Q546P5
resolver
uniprot
Q63576
resolver
uniprot
Q9UE55
resolver
uniprot_entry
A2VCK8_HUMAN
resolver
uniprot_entry
Q0P5T0_HUMAN
resolver
uniprot_entry
TYB4_HUMAN
resolver
uniprot_sec
P01253
resolver
uniprot_sec
P01254
resolver
uniprot_sec
Q546P5
resolver
uniprot_sec
Q63576
resolver
uniprot_sec
Q9UE55
resolver
amino_acid_sequence
MSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
uniprot
proteins
function
FUNCTION: Plays an important role in the organization of the cytoskeleton (PubMed:10848969, PubMed:1999398). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed:10848969, PubMed:1999398). {ECO:0000269|PubMed:10848969, ECO:0000269|PubMed:1999398}.; FUNCTION: [Hemoregulatory peptide AcSDKP]: Potent inhibitor of bone marrow derived stem cell differentiation (PubMed:7694679). Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity). {ECO:0000250|UniProtKB:P62326, ECO:0000269|PubMed:7694679}.
uniprot
proteins
mass_dalton
5053
uniprot
proteins
mutagenesis
MUTAGEN 12; /note="K->P: Very weak actin binding; no inhibition of actin polymerization."; MUTAGEN 16; /note="S->A: Binds actin 2.5-fold less than wild-type; little change in inhibition of actin polymerization."; MUTAGEN 16; /note="S->AS: Very weak actin binding; no inhibition of actin polymerization."; MUTAGEN 18; /note="L->A,P: Very weak actin binding; no inhibition of actin polymerization.
uniprot
proteins
post_translational_modification
PTM: [Hemoregulatory peptide AcSDKP]: AcSDKP is inactivated by ACE, which removes the dipeptide Lys-Pro from its C-terminus. {ECO:0000269|PubMed:7876104, ECO:0000269|PubMed:8257427}.
uniprot
proteins
protein_family
Thymosin beta family
uniprot
proteins
pubmed
10848969
uniprot
proteins
pubmed
16010977
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
1999398
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23009842
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25946035
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
3500230
uniprot
proteins
pubmed
6548414
uniprot
proteins
pubmed
7694679
uniprot
proteins
pubmed
7876104
uniprot
proteins
pubmed
8257427
uniprot
proteins
sequence_length
44
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:1999398}.
uniprot
proteins