P2RX1
entrez
5023
canonical
uniprot
P51575
canonical
ensembl
ENSG00000108405
resolver
ensp
ENSP00000225538
resolver
ensp
ENSP00000531613
resolver
ensp
ENSP00000638448
resolver
enst
ENST00000225538
resolver
genesymbol
P2RX1
resolver
genesymbol_syn
P2X1
resolver
hgnc
HGNC:8533
resolver
uniprot
Q9UK84
resolver
uniprot_entry
P2RX1_HUMAN
resolver
uniprot_sec
Q9UK84
resolver
activity_regulation
ACTIVITY REGULATION: Activated by low concentrations of ATP (<1 uM) (PubMed:10440098, PubMed:8834001). Undergoes rapid desensitization (PubMed:10440098). Sensitive to the ATP agonist:alpha/beta-methylene-ATP (PubMed:19635923, PubMed:8834001). Modulated by cholesterol (PubMed:20699225). {ECO:0000269|PubMed:10440098, ECO:0000269|PubMed:19635923, ECO:0000269|PubMed:20699225, ECO:0000269|PubMed:8834001}.
uniprot
proteins
amino_acid_sequence
MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSGLISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHPEGGICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESGQNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNLSPGFNFRFARHFVENGTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGAAERDLAATSSTLGLQENMRTS
uniprot
proteins
function
FUNCTION: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability (PubMed:10440098, PubMed:15056721, PubMed:20699225, PubMed:8834001, PubMed:8961184). Furthermore, CTP functions as a weak affinity agonist for P2RX1 (PubMed:14699168). Plays a role a role in urogenital, immune and cardiovascular function (By similarity). Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function (By similarity). In addition, contributes to smooth muscle contractions of the urinary bladder (By similarity). On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis (By similarity). On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells (PubMed:19635923). {ECO:0000250|UniProtKB:P51576, ECO:0000269|PubMed:10440098, ECO:0000269|PubMed:14699168, ECO:0000269|PubMed:15056721, ECO:0000269|PubMed:19635923, ECO:0000269|PubMed:20699225, ECO:0000269|PubMed:8834001, ECO:0000269|PubMed:8961184}.
uniprot
proteins
mass_dalton
44980
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
10440098
uniprot
proteins
pubmed
10816552
uniprot
proteins
pubmed
11809854
uniprot
proteins
pubmed
14699168
uniprot
proteins
pubmed
15056721
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19635923
uniprot
proteins
pubmed
20699225
uniprot
proteins
pubmed
22971236
uniprot
proteins
pubmed
8809107
uniprot
proteins
pubmed
8834001
uniprot
proteins
pubmed
8961184
uniprot
proteins
pubmed
9565569
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10816552, ECO:0000269|PubMed:11809854}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}. Note=Detected at plasma membrane lipid rafts. {ECO:0000269|PubMed:20699225}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..50; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 339..358; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins