PPME1
entrez
51400
canonical
uniprot
Q9Y570
canonical
ensembl
ENSG00000214517
resolver
ensp
ENSP00000329867
resolver
ensp
ENSP00000381461
resolver
ensp
ENSP00000665854
resolver
genesymbol
PPME1
resolver
genesymbol_syn
PME1
resolver
hgnc
HGNC:30178
resolver
uniprot
A0A140VK39
resolver
uniprot
B3KMU6
resolver
uniprot
B5MEE7
resolver
uniprot
J3QT22
resolver
uniprot
Q8WYG8
resolver
uniprot
Q9NVT5
resolver
uniprot
Q9UI18
resolver
uniprot_entry
A0A140VK39_HUMAN
resolver
uniprot_entry
PPME1_HUMAN
resolver
uniprot_sec
B3KMU6
resolver
uniprot_sec
B5MEE7
resolver
uniprot_sec
J3QT22
resolver
uniprot_sec
Q8WYG8
resolver
uniprot_sec
Q9NVT5
resolver
uniprot_sec
Q9UI18
resolver
amino_acid_sequence
MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFSPVPWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRSHGETKVKNPEDLSAETMAKDVGNVVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESISKRKKEDDMETKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC
uniprot
proteins
ec_number
3.1.1.89
uniprot
proteins
function
FUNCTION: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000269|PubMed:10318862}.
uniprot
proteins
mass_dalton
42315
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1. {ECO:0000250}.
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
10318862
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18394995
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
386
uniprot
proteins