Mecom
entrez
14013
canonical
uniprot
P14404
canonical
ensembl
ENSMUSG00000027684
resolver
ensp
ENSMUSP00000103905
resolver
ensp
ENSMUSP00000133310
resolver
ensp
ENSMUSP00000133410
resolver
ensp
ENSMUSP00000134303
resolver
ensp
ENSMUSP00000134626
resolver
ensp
ENSMUSP00000241863
resolver
ensp
ENSMUSP00000241869
resolver
ensp
ENSMUSP00000241870
resolver
ensp
ENSMUSP00000241873
resolver
enst
ENSMUST00000172694
resolver
enst
ENSMUST00000173495
resolver
genesymbol
Mecom
resolver
genesymbol_syn
Evi1
resolver
genesymbol_syn
Mds1
resolver
genesymbol_syn
Prdm3
resolver
uniprot
G3UWT0
resolver
uniprot
G3UZ13
resolver
uniprot
G3UZT5
resolver
uniprot
H9T841
resolver
uniprot
Q9Z1L8
resolver
uniprot_entry
G3UZ13_MOUSE
resolver
uniprot_entry
G3UZT5_MOUSE
resolver
uniprot_entry
H9T841_MOUSE
resolver
uniprot_entry
MECOM_MOUSE
resolver
uniprot_sec
G3UWT0
resolver
uniprot_sec
Q9Z1L8
resolver
amino_acid_sequence
MRSKGRARKLATSNECAYGNYPEIPLEEMPDADADGITSVPSLHIQEPCSPATSSESFTPKEGSPYKAPIYIPDDIPIPDEFELRESTMPGAGLGIWTKRKIEIGEKFGPYMGEQRSDLKDSSYGWEILDEFCNVKFCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEEDPHEPMAPDIHEERQHRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDLQQNLESESDLREIHGNQDCKECDRVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGTNRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASPPVKGLSSTEQSNKCQSPLLTHPQILPATQDILKALSKHPPVGDNKPVELLPERSSEERPLEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDLESDKEKCKENGKMFKDKVSPLQNLASITNKKEHNNHSVFSASVEEQSAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQSPSEVKKLQKGSSESPFDLTTKRKDEKPLTSGPSKPSGTPATSQDQPLDLSMGSRGRASGTKLTEPRKNHVFGEKKGSNMDTRPSSDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQSVPSMFSFRAPPNTLPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESAGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNMEERMNGSHFKDKKALATSQNSDLLDDEEVEDEVLLDEEDEDNDIPGKPRKELGVTRLDEEIPEDDYEEAGALEMSCKASPVRYKEEDYKSGLSALDHIRHFTDSLKMREMEENQYTDAELSSISSSHVPEELKQTLHRKSKSQAYAMMLSLSDKDSLHPTSHSSSNVWHSMARAAAESSAIQSISHV
uniprot
proteins
ec_number
2.1.1.367
uniprot
proteins
function
FUNCTION: [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:15889140, ECO:0000269|PubMed:18619962, ECO:0000269|PubMed:19767769}.; FUNCTION: [Isoform 3]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) (PubMed:22939622). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (PubMed:22939622). Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation (PubMed:22939622). {ECO:0000269|PubMed:22939622}.
uniprot
proteins
mass_dalton
138100
uniprot
proteins
post_translational_modification
PTM: May be acetylated by CREBBP and KAT2B. {ECO:0000250|UniProtKB:Q03112}.
uniprot
proteins
pubmed
15889140
uniprot
proteins
pubmed
18619962
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19767769
uniprot
proteins
pubmed
2106070
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22939622
uniprot
proteins
pubmed
2842066
uniprot
proteins
pubmed
9256345
uniprot
proteins
pubmed
9837768
uniprot
proteins
sequence_length
1232
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:2106070}. Nucleus speckle {ECO:0000250|UniProtKB:Q03112}. Cytoplasm {ECO:0000250|UniProtKB:Q03112}.
uniprot
proteins