SMTNL1
entrez
219537
canonical
uniprot
A8MU46
canonical
ensembl
ENSG00000214872
resolver
ensp
ENSP00000432651
resolver
enst
ENST00000527972
resolver
genesymbol
SMTNL1
resolver
hgnc
HGNC:32394
resolver
uniprot
E9PPJ3
resolver
uniprot_entry
SMTL1_HUMAN
resolver
uniprot_sec
E9PPJ3
resolver
amino_acid_sequence
MEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK
uniprot
proteins
function
FUNCTION: Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
52987
uniprot
proteins
post_translational_modification
PTM: Maximal phosphorylation of Ser-336 correlates with maximal relaxation of aorta in response to acetylcholine. {ECO:0000250}.
uniprot
proteins
protein_family
Smoothelin family
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18310078
uniprot
proteins
pubmed
20634291
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, myofibril {ECO:0000269|PubMed:18310078}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm (By similarity). Phosphorylation at Ser-301 promotes translocation to the nucleus (By similarity). {ECO:0000250}.
uniprot
proteins