DVL3
entrez
1857
canonical
uniprot
Q92997
canonical
ensembl
ENSG00000161202
resolver
ensp
ENSP00000316054
resolver
genesymbol
DVL3
resolver
genesymbol_syn
KIAA0208
resolver
hgnc
HGNC:3087
resolver
uniprot
B4E3E5
resolver
uniprot
D3DNT0
resolver
uniprot
O14642
resolver
uniprot
Q13531
resolver
uniprot
Q8N5E9
resolver
uniprot
Q92607
resolver
uniprot_entry
DVL3_HUMAN
resolver
uniprot_sec
B4E3E5
resolver
uniprot_sec
D3DNT0
resolver
uniprot_sec
O14642
resolver
uniprot_sec
Q13531
resolver
uniprot_sec
Q8N5E9
resolver
uniprot_sec
Q92607
resolver
amino_acid_sequence
MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPDPAPFCADNPSELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHATRLNGTAKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLASSLRSHHTHPSYGPPGVPPLYGPPMLMMPPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM
uniprot
proteins
disease_involvement
DISEASE: Robinow syndrome, autosomal dominant 3 (DRS3) [MIM:616894]: A form of Robinow syndrome, a rare skeletal dysplasia syndrome characterized by dysmorphic features resembling a fetal face, mesomelic limb shortening, genital hypoplasia, renal anomalies, and costovertebral segmentation defects. {ECO:0000269|PubMed:26924530}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}.
uniprot
proteins
mass_dalton
78055
uniprot
proteins
mutagenesis
MUTAGEN 271; /note="R->K: Localizes to plasma membranes."; /evidence="ECO:0000269|PubMed:23150776"; MUTAGEN 342; /note="R->K: No effect on subcellular location."; /evidence="ECO:0000269|PubMed:23150776"; MUTAGEN 614; /note="R->K: Localizes to plasma membranes."; /evidence="ECO:0000269|PubMed:23150776
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. {ECO:0000269|PubMed:20227366}.; PTM: Phosphorylated by CSNK1D. {ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:22612246}.; PTM: Arginine methylation may function as a switch in regulation of function in Wnt signaling. {ECO:0000269|PubMed:22612246, ECO:0000269|PubMed:23150776}.
uniprot
proteins
protein_family
DSH family
uniprot
proteins
pubmed
12805222
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15677333
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20227366
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21422228
uniprot
proteins
pubmed
22612246
uniprot
proteins
pubmed
22863007
uniprot
proteins
pubmed
23150776
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25557784
uniprot
proteins
pubmed
25805136
uniprot
proteins
pubmed
26924530
uniprot
proteins
pubmed
8817329
uniprot
proteins
pubmed
9039502
uniprot
proteins
pubmed
9192851
uniprot
proteins
pubmed
9344861
uniprot
proteins
sequence_length
716
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O14641}.
uniprot
proteins