Mocs2
entrez
17434
canonical
uniprot
Q9Z223
canonical
uniprot
Q9Z224
canonical
ensembl
ENSMUSG00000015536
resolver
ensp
ENSMUSP00000015680
resolver
ensp
ENSMUSP00000125797
resolver
ensp
ENSMUSP00000129021
resolver
ensp
ENSMUSP00000133069
resolver
ensp
ENSMUSP00000139064
resolver
ensp
ENSMUSP00000139355
resolver
ensp
ENSMUSP00000316513
resolver
enst
ENSMUST00000164737
resolver
genesymbol
Mocs2
resolver
uniprot
A0A0R4J206
resolver
uniprot
E9PVP5
resolver
uniprot
F6ZGI7
resolver
uniprot
Q8C5E5
resolver
uniprot
Q8R1M7
resolver
uniprot
Q9D6Q0
resolver
uniprot
Q9DCK1
resolver
uniprot_entry
E9PVP5_MOUSE
resolver
uniprot_entry
MOC2A_MOUSE
resolver
uniprot_entry
MOC2B_MOUSE
resolver
uniprot_sec
A0A0R4J206
resolver
uniprot_sec
F6ZGI7
resolver
uniprot_sec
Q8C5E5
resolver
uniprot_sec
Q8R1M7
resolver
uniprot_sec
Q9D6Q0
resolver
uniprot_sec
Q9DCK1
resolver
amino_acid_sequence
MSSLEISNSCFSPETRSPSSRQSVEDNASEPSGKDVDDVQEKPKDIIQFTAEKLSVGEVSQLVVSPLCGAVSLFVGTTRNNFEGKKVISLEYEAYVPMAENEIRKICNDIRQKWPVRHIAVFHRLGLVPVSEASTVIAVSSAHRAASLEAVSYAIDSLKAKVPIWKKEIYEESTSSWKRNKECFWAAGD
uniprot
proteins
amino_acid_sequence
MVPRCQIDVLYFAKSAEIAGVRSETISVPQEIKASELWKELESLHPGLADVRNQVIFAVRQEYVELGDQQLLLQPGDEVAIIPPISGG
uniprot
proteins
ec_number
2.8.1.12
uniprot
proteins
function
FUNCTION: Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin. {ECO:0000250|UniProtKB:O96033}.
uniprot
proteins
function
FUNCTION: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group (By similarity). Together with MBIP, inhibits the activity of stress kinase EIF2AK2/PKR; this may suppress JNK activation and subsequent stress-responsive transcription, or suppress eIF2a phosphorylation to favor translation (By similarity). {ECO:0000250|UniProtKB:O96007, ECO:0000255|HAMAP-Rule:MF_03052}.
uniprot
proteins
mass_dalton
20924
uniprot
proteins
mass_dalton
9701
uniprot
proteins
mutagenesis
MUTAGEN 30..88; /note="Missing: The activity of sulfite oxidase is undetectable."; /evidence="ECO:0000269|PubMed:30810871
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03051}.
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03052}.
uniprot
proteins
post_translational_modification
PTM: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3. {ECO:0000255|HAMAP-Rule:MF_03051}.
uniprot
proteins
protein_family
MOCS2A subfamily
uniprot
proteins
protein_family
MOCS2B subfamily
uniprot
proteins
protein_family
MoaD family
uniprot
proteins
protein_family
MoaE family
uniprot
proteins
pubmed
10053003
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27138983
uniprot
proteins
pubmed
30810871
uniprot
proteins
sequence_length
189
uniprot
proteins
sequence_length
88
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O96007, ECO:0000255|HAMAP-Rule:MF_03052}. Nucleus {ECO:0000250|UniProtKB:O96007}.
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_03051}. Nucleus {ECO:0000250|UniProtKB:O96033}.
uniprot
proteins