OPRK1
entrez
4986
canonical
uniprot
P41145
canonical
ensembl
ENSG00000082556
resolver
ensp
ENSP00000265572
resolver
ensp
ENSP00000430923
resolver
ensp
ENSP00000500765
resolver
enst
ENST00000673285
resolver
genesymbol
OPRK1
resolver
genesymbol_syn
OPRK
resolver
hgnc
HGNC:8154
resolver
uniprot
A0A5F9ZI09
resolver
uniprot
E5RHC9
resolver
uniprot
Q499G4
resolver
uniprot_entry
A0A5F9ZI09_HUMAN
resolver
uniprot_entry
OPRK_HUMAN
resolver
uniprot_sec
E5RHC9
resolver
uniprot_sec
Q499G4
resolver
amino_acid_sequence
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
uniprot
proteins
function
FUNCTION: G protein-coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.
uniprot
proteins
mass_dalton
42645
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12004055
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16431922
uniprot
proteins
pubmed
17711303
uniprot
proteins
pubmed
20401607
uniprot
proteins
pubmed
20729876
uniprot
proteins
pubmed
22437504
uniprot
proteins
pubmed
7624359
uniprot
proteins
pubmed
7869844
uniprot
proteins
pubmed
7929306
uniprot
proteins
pubmed
8060324
uniprot
proteins
sequence_length
380
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}; Multi-pass membrane protein {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..85; /note="Helical; Name=1"; TRANSMEM 96..119; /note="Helical; Name=2"; TRANSMEM 133..154; /note="Helical; Name=3"; TRANSMEM 174..196; /note="Helical; Name=4"; TRANSMEM 223..247; /note="Helical; Name=5"; TRANSMEM 275..296; /note="Helical; Name=6"; TRANSMEM 312..333; /note="Helical; Name=7
uniprot
proteins