Lrrc8d
entrez
305131
canonical
uniprot
Q5U308
canonical
ensembl
ENSRNOG00000002121
resolver
ensp
ENSRNOP00000002888
resolver
ensp
ENSRNOP00000078114
resolver
ensp
ENSRNOP00000081098
resolver
ensp
ENSRNOP00000087579
resolver
ensp
ENSRNOP00000090251
resolver
ensp
ENSRNOP00000091428
resolver
ensp
ENSRNOP00000092059
resolver
ensp
ENSRNOP00000096115
resolver
ensp
ENSRNOP00000096292
resolver
ensp
ENSRNOP00000105257
resolver
enst
ENSRNOT00000002888
resolver
enst
ENSRNOT00000094660
resolver
enst
ENSRNOT00000105738
resolver
enst
ENSRNOT00000106093
resolver
enst
ENSRNOT00000109682
resolver
enst
ENSRNOT00000112887
resolver
enst
ENSRNOT00000117756
resolver
enst
ENSRNOT00000118999
resolver
enst
ENSRNOT00000119904
resolver
enst
ENSRNOT00000138025
resolver
genesymbol
Lrrc8d
resolver
genesymbol_syn
Lrrc5
resolver
uniprot
A0A0H2UHA3
resolver
uniprot_entry
A0A0H2UHA3_RAT
resolver
uniprot_entry
LRC8D_RAT
resolver
amino_acid_sequence
MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPANSKAHTPPGNADVTTEVPKMETATPQDQNGQTTNDIAFGTSAVTPDIPLQATYSHAESTFPSQETKKEKRDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVSTSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTLIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLTGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHVSRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNSIRTIEEIISFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDVLPKQLFKCVKLRTLNLGQNCIASLPEKISQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDQLFDTLPLEVKEALNQDVNVPFANGI
uniprot
proteins
function
FUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:28833202). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:28833202). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity). {ECO:0000250|UniProtKB:Q7L1W4, ECO:0000250|UniProtKB:Q8BGR2, ECO:0000269|PubMed:28833202}.
uniprot
proteins
mass_dalton
97940
uniprot
proteins
protein_family
LRRC8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28833202
uniprot
proteins
sequence_length
858
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28833202}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7L1W4}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q7L1W4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7L1W4}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane. {ECO:0000250|UniProtKB:Q7L1W4}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..48; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q7L1W4"; TRANSMEM 164..182; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q7L1W4"; TRANSMEM 309..330; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q7L1W4"; TRANSMEM 361..386; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q7L1W4
uniprot
proteins