Ddx41
entrez
72935
canonical
uniprot
Q91VN6
canonical
ensembl
ENSMUSG00000021494
resolver
ensp
ENSMUSP00000021956
resolver
enst
ENSMUST00000021956
resolver
genesymbol
Ddx41
resolver
uniprot
Q3U0E0
resolver
uniprot
Q3UAC4
resolver
uniprot
Q9CUY2
resolver
uniprot_entry
DDX41_MOUSE
resolver
uniprot_entry
Q3UAC4_MOUSE
resolver
uniprot_entry
Q9CUY2_MOUSE
resolver
uniprot_sec
Q3U0E0
resolver
amino_acid_sequence
MEDSEPERKRARADEATAGGSRSEDEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGATEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVAEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKFPAAILRGLKKKGILHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGERGCAFCGGLGHRITDCPKLEAMQTKQVSNIGRKDYLAHSSMDF
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and hematopoietic homeostasis (PubMed:35303436). Recognizes foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses. Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1. Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity. In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses (PubMed:21892174). During murine leukemia virus infection, primarily senses the DNA/RNA hybrid generated at the first step of reverse transcription, while cGAS recognizes dsDNA generated at the next step and both are needed for the antiretroviral innate immune response (PubMed:29871919). Selectively modulates the transcription of certain immunity-associated genes by regulating their alternative splicing. Binds to RNA (R)-loops, structures consisting of DNA/RNA hybrids and a displaced strand of DNA that occur during transcription, and prevents their accumulation, thereby maintaining genome stability. Also participates in pre-mRNA splicing, translational regulation and snoRNA processing, which is essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q9UJV9, ECO:0000269|PubMed:21892174, ECO:0000269|PubMed:29871919, ECO:0000269|PubMed:35303436}.
uniprot
proteins
mass_dalton
69820
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-9 regulates the nuclear/cytoplasmic localization. {ECO:0000250|UniProtKB:Q9UJV9}.; PTM: Phosphorylated by BTK; phosphorylation induces binding to dsDNA and STING1. {ECO:0000250|UniProtKB:Q9UJV9}.; PTM: 'Lys-48'-linked ubiquitinated and degraded by TRIM21 leading to negative regulation of the innate immune response to intracellular dsDNA. {ECO:0000250|UniProtKB:Q9UJV9}.
uniprot
proteins
protein_family
DDX41 subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21892174
uniprot
proteins
pubmed
29871919
uniprot
proteins
pubmed
35303436
uniprot
proteins
sequence_length
622
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UJV9}. Cytoplasm {ECO:0000250|UniProtKB:Q9UJV9}. Note=Predominantly present in the nucleus and traffics to the cytoplasm, specifically in the perinuclear region, after DNA stimulation. {ECO:0000250|UniProtKB:Q9UJV9}.
uniprot
proteins