CHMP6
entrez
79643
canonical
uniprot
Q96FZ7
canonical
ensembl
ENSG00000176108
resolver
ensp
ENSP00000317468
resolver
ensp
ENSP00000461098
resolver
enst
ENST00000325167
resolver
genesymbol
CHMP6
resolver
genesymbol_syn
VPS20
resolver
hgnc
HGNC:25675
resolver
uniprot
A8K7U0
resolver
uniprot
Q53FU4
resolver
uniprot
Q9HAE8
resolver
uniprot_entry
CHMP6_HUMAN
resolver
uniprot_sec
A8K7U0
resolver
uniprot_sec
Q53FU4
resolver
uniprot_sec
Q9HAE8
resolver
amino_acid_sequence
MGNLFGRKKQSRVTEQDKAILQLKQQRDKLRQYQKRIAQQLERERALARQLLRDGRKERAKLLLKKKRYQEQLLDRTENQISSLEAMVQSIEFTQIEMKVMEGLQFGNECLNKMHQVMSIEEVERILDETQEAVEYQRQIDELLAGSFTQEDEDAILEELSAITQEQIELPEVPSEPLPEKIPENVPVKARPRQAELVAAS
uniprot
proteins
function
FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.
uniprot
proteins
mass_dalton
23485
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Abolishes myristoylation."; /evidence="ECO:0000269|PubMed:15511219"; MUTAGEN 49; /note="R->E: Does not affect the subcellular location."; /evidence="ECO:0000269|PubMed:15511219"; MUTAGEN 168..201; /note="Missing: Membrane association; releases autoinhibition."; /evidence="ECO:0000269|PubMed:17547705"; MUTAGEN 170; /note="L->D: Abolishes interaction with VPS4A."; /evidence="ECO:0000269|PubMed:18606141"; MUTAGEN 173; /note="V->D: Abolishes interaction with VPS4A."; /evidence="ECO:0000269|PubMed:18606141"; MUTAGEN 178; /note="L->D: Reduces interaction with VPS4A."; /evidence="ECO:0000269|PubMed:18606141
uniprot
proteins
post_translational_modification
PTM: ISGylated in a CHMP5-dependent manner. Isgylation weakens its interaction with VPS4A. {ECO:0000269|PubMed:21543490}.
uniprot
proteins
protein_family
SNF7 family
uniprot
proteins
pubmed
14505570
uniprot
proteins
pubmed
14519844
uniprot
proteins
pubmed
14583093
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15511219
uniprot
proteins
pubmed
17547705
uniprot
proteins
pubmed
18606141
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21543490
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane {ECO:0000305}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Localizes to endosomal membranes.
uniprot
proteins