BATF2
entrez
116071
canonical
uniprot
Q8N1L9
canonical
ensembl
ENSG00000168062
resolver
ensp
ENSP00000301887
resolver
ensp
ENSP00000398911
resolver
ensp
ENSP00000434915
resolver
enst
ENST00000527716
resolver
genesymbol
BATF2
resolver
hgnc
HGNC:25163
resolver
uniprot
B4DV37
resolver
uniprot
D9IC56
resolver
uniprot
F6UKE0
resolver
uniprot
Q8NAF4
resolver
uniprot
Q8NAL8
resolver
uniprot
Q96EH4
resolver
uniprot_entry
B4DV37_HUMAN
resolver
uniprot_entry
BATF2_HUMAN
resolver
uniprot_entry
F6UKE0_HUMAN
resolver
uniprot_sec
D9IC56
resolver
uniprot_sec
Q8NAF4
resolver
uniprot_sec
Q8NAL8
resolver
uniprot_sec
Q96EH4
resolver
amino_acid_sequence
MHLCGGNGLLTQTDPKEQQRQLKKQKNRAAAQRSRQKHTDKADALHQQHESLEKDNLALRKEIQSLQAELAWWSRTLHVHERLCPMDCASCSAPGLLGCWDQAEGLLGPGPQGQHGCREQLELFQTPGSCYPAQPLSPGPQPHDSPSLLQCPLPSLSLGPAVVAEPPVQLSPSPLLFASHTGSSLQGSSSKLSALQPSLTAQTAPPQPLELEHPTRGKLGSSPDNPSSALGLARLQSREHKPALSAATWQGLVVDPSPHPLLAFPLLSSAQVHF
uniprot
proteins
function
FUNCTION: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter. {ECO:0000250, ECO:0000269|PubMed:20531301}.
uniprot
proteins
mass_dalton
29398
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19074269
uniprot
proteins
pubmed
20473897
uniprot
proteins
pubmed
20531301
uniprot
proteins
sequence_length
274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
uniprot
proteins