Cnpy3
entrez
72029
canonical
uniprot
Q9DAU1
canonical
ensembl
ENSMUSG00000023973
resolver
ensp
ENSMUSP00000050309
resolver
ensp
ENSMUSP00000187756
resolver
genesymbol
Cnpy3
resolver
genesymbol_syn
Prat4a
resolver
genesymbol_syn
Tnrc5
resolver
uniprot
Q571I0
resolver
uniprot
Q8BUS5
resolver
uniprot
Q8BUV5
resolver
uniprot
Q8C0C5
resolver
uniprot_entry
CNPY3_MOUSE
resolver
uniprot_sec
Q571I0
resolver
uniprot_sec
Q8BUS5
resolver
uniprot_sec
Q8BUV5
resolver
uniprot_sec
Q8C0C5
resolver
amino_acid_sequence
MESMSELAPRCLLFPLLLLLPLLLLPAPKLGPSPAGAEETDWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIDTGYGILDGKGSGVKYTKSDLRLIEVTETICKRLLDYSLHKERTGSNRFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDWYRNHQEEDLTEFLCANHVLKGKDTSCLAERWSGKKGDIASLGGKKSKKKRSGVKGSSSGSSKQRKELGGLGEDANAEEEEGVQKASPLPHSPPDEL
uniprot
proteins
function
FUNCTION: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses. {ECO:0000269|PubMed:16849487, ECO:0000269|PubMed:17998391, ECO:0000269|PubMed:20865800}.
uniprot
proteins
mass_dalton
30538
uniprot
proteins
mutagenesis
MUTAGEN 95; /note="R->L: Does not affect association with TLR2, TLR4 and TLR9; does not affect cell-surface expression of TLR2, TLR4 and TLR9; does not affect responses of TLR2, TLR4 and TLR9."; /evidence="ECO:0000269|PubMed:18780723"; MUTAGEN 145; /note="M->K: Loss of HSP90B1-binding. Impairs association with TLR2 and TLR4; does not impair association with TLR9; partially affects responses of TLR2 and TLR4; affects responses of TLR9; does not affect cell-surface expression of TLR2; affects cell-surface expression of TLR4 and TLR9."; /evidence="ECO:0000269|PubMed:18780723, ECO:0000269|PubMed:20865800"; MUTAGEN 231; /note="S->I: Does not affect association with TLR2, TLR4 and TLR9; does not affect cell-surface expression of TLR2, TLR4 and TLR9; does not affect responses of TLR2, TLR4 and TLR9."; /evidence="ECO:0000269|PubMed:18780723
uniprot
proteins
protein_family
Canopy family
uniprot
proteins
pubmed
12511604
uniprot
proteins
pubmed
15449545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16338228
uniprot
proteins
pubmed
16849487
uniprot
proteins
pubmed
17998391
uniprot
proteins
pubmed
18780723
uniprot
proteins
pubmed
20865800
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29394991
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:17998391, ECO:0000269|PubMed:20865800}.
uniprot
proteins