Abca7
entrez
27403
canonical
uniprot
Q91V24
canonical
ensembl
ENSMUSG00000035722
resolver
ensp
ENSMUSP00000043090
resolver
ensp
ENSMUSP00000115111
resolver
ensp
ENSMUSP00000128121
resolver
ensp
ENSMUSP00000332145
resolver
enst
ENSMUST00000043866
resolver
enst
ENSMUST00000132517
resolver
enst
ENSMUST00000171637
resolver
genesymbol
Abca7
resolver
uniprot
E9Q6G4
resolver
uniprot
Q9JL36
resolver
uniprot_entry
ABCA7_MOUSE
resolver
uniprot_entry
E9Q6G4_MOUSE
resolver
uniprot_sec
Q9JL36
resolver
amino_acid_sequence
MALGTQLMLLLWKNYTYRRRQPIQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAGTVPWLQGLVCNVNNSCFQHPTPGEKPGVLSNFKDSLISRLLADTRTVLGGHSIQDMLDALGKLIPVLRAVGGGARPQESDQPTSQGSVTKLLEKILQRASLDPVLGQAQDSMRKFSDAIRDLAQELLTLPSLMELRALLRRPRGSAGSLELVSEALCSTKGPSSPGGLSLNWYEANQLNEFMGPEVAPALPDNSLSPACSEFVGTLDDHPVSRLLWRRLKPLILGKILFAPDTNFTRKLMAQVNQTFEELALLRDLHELWGVLGPQIFNFMNDSTNVAMLQRLLDVGGTGQRQQTPRAQKKLEAIKDFLDPSRGGYSWREAHADMGRLAGILGQMMECVSLDKLEAVPSEEALVSRALELLGERRLWAGIVFLSPEHPLDPSELSSPALSPGHLRFKIRMDIDDVTRTNKIRDKFWDPGPSADPFMDLRYVWGGFVYLQDLLEQAAVRVLGGGNSRTGLYLQQMPHPCYVDDVFLRVLSRSLPLFLTLAWIYSVALTVKAVVREKETRLRETMRAMGLSRAVLWLGWFLSCLGPFLVSAALLVLVLKLGNILPYSHPVVIFLFLAAFAVATVAQSFLLSAFFSRANLAAACGGLAYFALYLPYVLCVAWRERLHLGGLLAASLLSPVAFGFGCESLALLEEQGDGAQWHNLGTGPAEDVFSLAQVSAFLLLDAVIYGLALWYLEAVCPGQYGIPEPWNFPFRRSYWCGPGPPKSSVLAPAPQDPKVLVEEPPLGLVPGVSIRGLKKHFRGCPQPALQGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLFPPSSGSASILGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLKGVSAAAMGPERERLIRDVGLTLKRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAMVAGGSLCCCGSPLFLRRHLGCGYYLTLVKSSQSLVTHDAKGDSEDPRREKKSDGNGRTSDTAFTRGTSDKSNQAPAPGAVPITPSTARILELVQQHVPGAQLVEDLPHELLLVLPYAGALDGSFAMVFQELDQQLELLGLTGYGISDTNLEEIFLKVVEDAHREGGDSRPQLHLRTCTPQPPTGPEASVLENGELAPQGLAPNAAQVQGWTLTCQQLRALLHKRFLLARRSRRGLFAQVVLPALFVGLALFFSLIVPPFGQYPPLQLSPAMYGPQVSFFSEDAPGDPNRMKLLEALLGEAGLQEPSMQDKDARGSECTHSLACYFTVPEVPPDVASILASGNWTPESPSPACQCSQPGARRLLPDCPAGAGGPPPPQAVAGLGEVVQNLTGRNVSDFLVKTYPSLVRRGLKTKKWVDEVRYGGFSLGGRDPDLPTGHEVVRTLAEIRALLSPQPGNALDRILNNLTQWALGLDARNSLKIWFNNKGWHAMVAFVNRANNGLLHALLPSGPVRHAHSITTLNHPLNLTKEQLSEATLIASSVDVLVSICVVFAMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNFLWDMCNYLVAVCIVVFIFLAFQQRAYVAPENLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINSSMATFVLELLSDQNLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDKQFQSPLRWDIIGKNLLAMMAQGPLFLLITLLLQHRNRLLPQSKPRLLPPLGEEDEDVAQERERVTKGATQGDVLVLRDLTKVYRGQRNPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLPSSGEAVLAGHNVAQERSAAHRSMGYCPQSDAIFDLLTGREHLELFARLRGVPEAQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLSVVREGRSVVLTSHSMEECEALCTRLAIMVNGRFRCLGSSQHLKGRFGAGHTLTLRVPPDQPEPAIAFIRITFPGAELREVHGSRLRFQLPPGGRCTLTRVFRELAAQGRAHGVEDFSVSQTTLEEVFLYFSKDQGEEEESSRQEAEEEEVSKPGRQHPKRVSRFLEDPSSVETMI
uniprot
proteins
function
FUNCTION: Probable ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:12917409, PubMed:15550377, PubMed:16908670, PubMed:20495215, PubMed:27030769, PubMed:27472885). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409). May also mediate cholesterol efflux (By similarity). May regulate cellular ceramide homeostasis during keratinocyte differentiation (By similarity). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (PubMed:28091533). Plays a role in phagocytosis of apoptotic cells by macrophages (PubMed:16908670). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (PubMed:20495215). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (PubMed:27472885). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791, PubMed:27030769). {ECO:0000250|UniProtKB:Q8IZY2, ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:15550377, ECO:0000269|PubMed:16908670, ECO:0000269|PubMed:20495215, ECO:0000269|PubMed:26260791, ECO:0000269|PubMed:27030769, ECO:0000269|PubMed:27472885, ECO:0000269|PubMed:28091533}.
uniprot
proteins
mass_dalton
236884
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:20495215}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCA family
uniprot
proteins
pubmed
10708515
uniprot
proteins
pubmed
11435699
uniprot
proteins
pubmed
12917409
uniprot
proteins
pubmed
15550377
uniprot
proteins
pubmed
16445568
uniprot
proteins
pubmed
16908670
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
20495215
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26260791
uniprot
proteins
pubmed
27030769
uniprot
proteins
pubmed
27472885
uniprot
proteins
pubmed
28091533
uniprot
proteins
sequence_length
2159
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:20495215, ECO:0000269|PubMed:26260791}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:16908670}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:16908670}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:27472885}. Cell projection, ruffle membrane {ECO:0000269|PubMed:16908670}. Cell projection, phagocytic cup {ECO:0000269|PubMed:16908670}. Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes (PubMed:16908670). Localizes to the apical brush border of cells in the proximal tubules of kidney (Probable). {ECO:0000269|PubMed:16908670, ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 547..567; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 590..610; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 623..643; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 652..672; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 678..698; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 732..752; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 846..866; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1246..1266; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1552..1572; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1598..1618; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1635..1655; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1663..1683; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1743..1763; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins