ASB8
entrez
140461
canonical
uniprot
Q9H765
canonical
ensembl
ENSG00000177981
resolver
ensp
ENSP00000320893
resolver
ensp
ENSP00000438498
resolver
ensp
ENSP00000440773
resolver
ensp
ENSP00000445540
resolver
ensp
ENSP00000445622
resolver
ensp
ENSP00000543870
resolver
ensp
ENSP00000543871
resolver
ensp
ENSP00000609025
resolver
ensp
ENSP00000612581
resolver
enst
ENST00000317697
resolver
enst
ENST00000535055
resolver
enst
ENST00000536549
resolver
enst
ENST00000536953
resolver
enst
ENST00000539528
resolver
enst
ENST00000873811
resolver
enst
ENST00000873812
resolver
enst
ENST00000938966
resolver
enst
ENST00000942522
resolver
genesymbol
ASB8
resolver
hgnc
HGNC:17183
resolver
uniprot
A8K1P2
resolver
uniprot
F5GYF0
resolver
uniprot
Q547Q2
resolver
uniprot_entry
ASB8_HUMAN
resolver
uniprot_entry
F5GYF0_HUMAN
resolver
uniprot_sec
A8K1P2
resolver
uniprot_sec
Q547Q2
resolver
amino_acid_sequence
MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREVARDPQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE
uniprot
proteins
function
FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits IFN-beta production through the IRF3 signaling pathway by targeting TBK1 via 'Lys-48'-linked ubiquitination, leading to its proteasomal degradation (PubMed:32298923). {ECO:0000269|PubMed:32298923}.
uniprot
proteins
mass_dalton
31642
uniprot
proteins
mutagenesis
MUTAGEN 17; /note="S->A: Almost complete lost of phosphorylation by TBK1."; /evidence="ECO:0000269|PubMed:32298923
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by TBK1. {ECO:0000269|PubMed:32298923}.
uniprot
proteins
protein_family
Ankyrin SOCS box (ASB) family
uniprot
proteins
pubmed
12559969
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
32298923
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12559969, ECO:0000269|PubMed:32298923}.
uniprot
proteins