Cxcr3
entrez
12766
canonical
uniprot
O88410
canonical
ensembl
ENSMUSG00000050232
resolver
ensp
ENSMUSP00000052444
resolver
enst
ENSMUST00000056614
resolver
genesymbol
Cxcr3
resolver
genesymbol_syn
Cmkar3
resolver
uniprot
Q4V9Y6
resolver
uniprot
Q9QWN6
resolver
uniprot_entry
CXCR3_MOUSE
resolver
uniprot_sec
Q4V9Y6
resolver
uniprot_sec
Q9QWN6
resolver
amino_acid_sequence
MYLEVSERQVLDASDFAFLLENSTSPYDYGENESDFSDSPPCPQDFSLNFDRTFLPALYSLLFLLGLLGNGAVAAVLLSQRTALSSTDTFLLHLAVADVLLVLTLPLWAVDAAVQWVFGPGLCKVAGALFNINFYAGAFLLACISFDRYLSIVHATQIYRRDPRVRVALTCIVVWGLCLLFALPDFIYLSANYDQRLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRFRAMRLVVVVVAAFAVCWTPYHLVVLVDILMDVGVLARNCGRESHVDVAKSVTSGMGYMHCCLNPLLYAFVGVKFREQMWMLFTRLGRSDQRGPQRQPSSSRRESSWSETTEASYLGL
uniprot
proteins
function
FUNCTION: Receptor for the C-X-C chemokines CXCL9, CXCL10 and CXCL11, and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G protein signaling pathway. Probably promotes cell chemotaxis response (By similarity). Receptor for chemokine CCL21 (PubMed:10201891, PubMed:9653165). Upon activation by PF4, induces activated T-lymphocyte migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. {ECO:0000250|UniProtKB:P49682, ECO:0000269|PubMed:10201891, ECO:0000269|PubMed:9653165, ECO:0000269|PubMed:9790904}.
uniprot
proteins
mass_dalton
41018
uniprot
proteins
post_translational_modification
PTM: Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding. {ECO:0000250}.; PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10201891
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9653165
uniprot
proteins
pubmed
9790904
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 53..79; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 89..109; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 125..146; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 169..188; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 212..232; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 255..276; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 298..320; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins