HSD17B13
entrez
345275
canonical
uniprot
Q7Z5P4
canonical
ensembl
ENSG00000170509
resolver
ensp
ENSP00000305438
resolver
ensp
ENSP00000333300
resolver
genesymbol
HSD17B13
resolver
genesymbol_syn
SCDR9
resolver
genesymbol_syn
SDR16C3
resolver
hgnc
HGNC:18685
resolver
uniprot
A8K9R9
resolver
uniprot
Q2M1L5
resolver
uniprot
Q86W22
resolver
uniprot
Q86W23
resolver
uniprot_entry
DHB13_HUMAN
resolver
uniprot_sec
A8K9R9
resolver
uniprot_sec
Q2M1L5
resolver
uniprot_sec
Q86W22
resolver
uniprot_sec
Q86W23
resolver
amino_acid_sequence
MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
ec_number
1.1.1.105
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
function
FUNCTION: Plays a pivotal role in hepatic lipid metabolism (PubMed:29562163). In vitro, it catalyzes the oxidation of a variety of lipid substrates, including 17beta-estradiol, retinol, retinal, and leukotriene B4 (PubMed:29562163, PubMed:30415504, PubMed:32973038). {ECO:0000269|PubMed:29562163, ECO:0000269|PubMed:30415504, ECO:0000269|PubMed:32973038}.; FUNCTION: [Isoform 2]: Has retinol/retinal dehydrogenase activity in vitro. {ECO:0000269|PubMed:30415504, ECO:0000269|PubMed:32973038}.; FUNCTION: [Isoform 1]: Does not have retinol/retinal dehydrogenase activity in vitro. {ECO:0000269|PubMed:30415504}.
uniprot
proteins
mass_dalton
33655
uniprot
proteins
mutagenesis
MUTAGEN 22..28; /note="Missing: Does not localize to lipid droplets."; /evidence="ECO:0000269|PubMed:30415504"; MUTAGEN 47..49; /note="GIG->AIA: Loss of retinol/retinal dehydrogenase activity."; /evidence="ECO:0000269|PubMed:30415504"; MUTAGEN 69..84; /note="Missing: Does not localize to lipid droplets."; /evidence="ECO:0000269|PubMed:32973038"; MUTAGEN 85..93; /note="Missing: Does not localize to lipid droplets."; /evidence="ECO:0000269|PubMed:32973038"; MUTAGEN 94..106; /note="Missing: Does not localize to lipid droplets."; /evidence="ECO:0000269|PubMed:32973038"; MUTAGEN 97; /note="R->A: Decreased retinol/retinal dehydrogenase activity; when associated with A-101."; /evidence="ECO:0000269|PubMed:32973038"; MUTAGEN 101; /note="Y->A: Decreased retinol/retinal dehydrogenase activity; when associated with A-97."; /evidence="ECO:0000269|PubMed:32973038"; MUTAGEN 144; /note="N->A: Loss of retinol/retinal dehydrogenase activity."; /evidence="ECO:0000269|PubMed:32973038"; MUTAGEN 153; /note="K->A: Loss of retinol/retinal dehydrogenase activity; when associated with A-156."; /evidence="ECO:0000269|PubMed:32973038"; MUTAGEN 156; /note="L->A: Loss of retinol/retinal dehydrogenase activity; when associated with A-153."; /evidence="ECO:0000269|PubMed:32973038"; MUTAGEN 172; /note="S->A: Loss of retinol/retinal dehydrogenase activity."; /evidence="ECO:0000269|PubMed:32973038"; MUTAGEN 185; /note="Y->A: Loss of retinol/retinal dehydrogenase activity; when associated with A-189."; /evidence="ECO:0000269|PubMed:32973038"; MUTAGEN 189; /note="K->A: Loss of retinol/retinal dehydrogenase activity; when associated with A-185."; /evidence="ECO:0000269|PubMed:32973038"; MUTAGEN 199; /note="L->A: Loss of retinol/retinal dehydrogenase activity; when associated with A-202."; /evidence="ECO:0000269|PubMed:32973038"; MUTAGEN 202; /note="E->A: Loss of retinol/retinal dehydrogenase activity; when associated with A-199."; /evidence="ECO:0000269|PubMed:32973038"; MUTAGEN 208; /note="K->A: Decreased retinol/retinal dehydrogenase activity."; /evidence="ECO:0000269|PubMed:32973038
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15221005
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17311113
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29562163
uniprot
proteins
pubmed
30415504
uniprot
proteins
pubmed
32973038
uniprot
proteins
pubmed
34930143
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Lipid droplet {ECO:0000269|PubMed:29562163, ECO:0000269|PubMed:30415504, ECO:0000269|PubMed:32973038}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8VCR2}. Note=Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation. {ECO:0000250|UniProtKB:Q8VCR2}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:30415504}. Note=Does not localize to lipid droplets. {ECO:0000269|PubMed:30415504}.
uniprot
proteins