GPR155
entrez
151556
canonical
uniprot
Q7Z3F1
canonical
ensembl
ENSG00000163328
resolver
ensp
ENSP00000295500
resolver
ensp
ENSP00000376334
resolver
ensp
ENSP00000376335
resolver
ensp
ENSP00000481104
resolver
ensp
ENSP00000556551
resolver
ensp
ENSP00000556552
resolver
ensp
ENSP00000602291
resolver
ensp
ENSP00000602292
resolver
ensp
ENSP00000619698
resolver
ensp
ENSP00000619699
resolver
ensp
ENSP00000619700
resolver
ensp
ENSP00000619701
resolver
ensp
ENSP00000619703
resolver
enst
ENST00000295500
resolver
enst
ENST00000392551
resolver
enst
ENST00000392552
resolver
enst
ENST00000614352
resolver
enst
ENST00000886492
resolver
enst
ENST00000886493
resolver
enst
ENST00000932232
resolver
enst
ENST00000932233
resolver
enst
ENST00000949639
resolver
enst
ENST00000949640
resolver
enst
ENST00000949641
resolver
enst
ENST00000949642
resolver
enst
ENST00000949644
resolver
genesymbol
GPR155
resolver
genesymbol_syn
PGR22
resolver
hgnc
HGNC:22951
resolver
uniprot
A0A087WXK4
resolver
uniprot
B2RCI2
resolver
uniprot
D3DPE2
resolver
uniprot
Q49AJ5
resolver
uniprot
Q4G0Y6
resolver
uniprot
Q53SJ3
resolver
uniprot
Q53TA8
resolver
uniprot
Q69YG8
resolver
uniprot
Q86SP9
resolver
uniprot
Q8N261
resolver
uniprot
Q8N639
resolver
uniprot
Q8N8K3
resolver
uniprot
Q96MV6
resolver
uniprot_entry
A0A087WXK4_HUMAN
resolver
uniprot_entry
LYCHS_HUMAN
resolver
uniprot_entry
Q49AJ5_HUMAN
resolver
uniprot_sec
B2RCI2
resolver
uniprot_sec
D3DPE2
resolver
uniprot_sec
Q4G0Y6
resolver
uniprot_sec
Q53SJ3
resolver
uniprot_sec
Q53TA8
resolver
uniprot_sec
Q69YG8
resolver
uniprot_sec
Q86SP9
resolver
uniprot_sec
Q8N261
resolver
uniprot_sec
Q8N639
resolver
uniprot_sec
Q8N8K3
resolver
uniprot_sec
Q96MV6
resolver
amino_acid_sequence
MNSNLPAENLTIAVNMTKTLPTAVTHGFNSTNDPPSMSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWSFLYSILIAKASVFFIVCVLTLLVASPDSRFSKAGLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKWKDTQNASQNKIKIVGLGLLRVLQNPIVFMVFIGIAFNFILDRKVPVYVENFLDGLGNSFSGSALFYLGLTMVGKIKRLKKSAFVVLILLITAKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDPKPLAYAIQNVSFDISIVSLISLIWSLAILLLSKKYKQLPHMLTTNLLIAQSIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAISLFLLKKRERVQIPVGIIIISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSILIAGISLMCMNQTAQAGSYEGFDQSQSHKVVEPGNTAFEESPAPVNEPELFTSSIPETSCCSCSMGNGELHCPSIEPIANTSTSEPVIPSFEKNNHCVSRCNSQSCILAQEEEQYLQSGDQQLTRHVLLCLLLIIGLFANLSSCLWWLFNQEPGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNNKDTAENRDSPVSEEIKMTCQQFIHYHRDLCIRNIVKERRCGAKTSAGTFCGCDLVSWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPEQSPPAINANTLQQERYKEIEHSSPPSHSPKT
uniprot
proteins
function
FUNCTION: Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway (PubMed:36007018). Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disruption of the interaction between the GATOR1 and KICSTOR complexes and promotion of mTORC1 signaling (PubMed:36007018, PubMed:39358511). Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition (PubMed:36007018). Binds indole-3-acetic acid and may play a role in tryptophan metabolism (PubMed:39358511). {ECO:0000269|PubMed:36007018, ECO:0000269|PubMed:39358511}.
uniprot
proteins
mass_dalton
96919
uniprot
proteins
mutagenesis
MUTAGEN 43..44; /note="FP->IA: Nearly abolished cholesterol-binding."; /evidence="ECO:0000269|PubMed:36007018"; MUTAGEN 43; /note="F->I: Strongly reduced cholesterol-binding."; /evidence="ECO:0000269|PubMed:36007018"; MUTAGEN 48; /note="E->Q: Does not affect cholesterol-binding."; /evidence="ECO:0000269|PubMed:36007018"; MUTAGEN 57; /note="Y->A: Strongly reduced cholesterol-binding. Abolishes cholesterol-dependent mTORC1 activity."; /evidence="ECO:0000269|PubMed:36007018, ECO:0000269|PubMed:39358511"; MUTAGEN 145; /note="N->A: Reduces binding to indole-3-acetic acid."; /evidence="ECO:0000269|PubMed:39358511"; MUTAGEN 148; /note="A->W: Reduces binding to indole-3-acetic acid."; /evidence="ECO:0000269|PubMed:39358511"; MUTAGEN 177; /note="L->W: Reduces binding to indole-3-acetic acid."; /evidence="ECO:0000269|PubMed:39358511"; MUTAGEN 352; /note="F->A: Abolishes the effect of cholesterol depletion in mTORC1 activity. Abolishes the effect of cholesterol depletion in mTORC1 activity; when associated with R-678."; /evidence="ECO:0000269|PubMed:39358511"; MUTAGEN 551; /note="Y->A: Abolished ability to regulate mTORC1."; /evidence="ECO:0000269|PubMed:36007018"; MUTAGEN 595; /note="C->A: In 4CA, abolished ability to regulate mTORC1; when associated with A-604, A-629 and A-638."; /evidence="ECO:0000269|PubMed:36007018"; MUTAGEN 604; /note="C->A: In 4CA, abolished ability to regulate mTORC1; when associated with A-595, A-629 and A-638."; /evidence="ECO:0000269|PubMed:36007018"; MUTAGEN 629; /note="C->A: In 4CA, abolished ability to regulate mTORC1; when associated with A-595, A-604 and A-638."; /evidence="ECO:0000269|PubMed:36007018"; MUTAGEN 638; /note="C->A: In 4CA, abolished ability to regulate mTORC1; when associated with A-595, A-604 and A-629."; /evidence="ECO:0000269|PubMed:36007018"; MUTAGEN 678; /note="W->R: Abolishes the effect of cholestrol depletion in mTORC1 activity; when associated with A-352."; /evidence="ECO:0000269|PubMed:39358511
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
36007018
uniprot
proteins
pubmed
39358511
uniprot
proteins
sequence_length
870
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:36007018}; Multi-pass membrane protein {ECO:0000269|PubMed:39358511}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X"; TRANSMEM 80..100; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X"; TRANSMEM 105..125; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X"; TRANSMEM 134..154; /note="Discontinuously helical; Name=4"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X"; TRANSMEM 168..188; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X"; TRANSMEM 214..234; /note="Discontinuously helical; Name=6"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X"; TRANSMEM 244..264; /note="Discontinuously helical; Name=7"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X"; TRANSMEM 274..294; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X"; TRANSMEM 316..336; /note="Discontinuously helical; Name=9"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X"; TRANSMEM 347..367; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X"; TRANSMEM 382..402; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X"; TRANSMEM 415..435; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X"; TRANSMEM 439..459; /note="Helical; Name=13"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X"; TRANSMEM 481..501; /note="Helical; Name=14"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X"; TRANSMEM 521..541; /note="Helical; Name=15"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X"; TRANSMEM 661..681; /note="Helical; Name=16"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X"; TRANSMEM 692..712; /note="Helical; Name=17"; /evidence="ECO:0000269|PubMed:39358511, ECO:0007744|PDB:8U54, ECO:0007744|PDB:8U56, ECO:0007744|PDB:8U58, ECO:0007744|PDB:8U5C, ECO:0007744|PDB:8U5N, ECO:0007744|PDB:8U5Q, ECO:0007744|PDB:8U5V, ECO:0007744|PDB:8U5X
uniprot
proteins