Mgrn1
entrez
17237
canonical
uniprot
Q9D074
canonical
ensembl
ENSMUSG00000022517
resolver
ensp
ENSMUSP00000023159
resolver
ensp
ENSMUSP00000068314
resolver
ensp
ENSMUSP00000155034
resolver
ensp
ENSMUSP00000278800
resolver
ensp
ENSMUSP00000278861
resolver
ensp
ENSMUSP00000338299
resolver
ensp
ENSMUSP00000338300
resolver
ensp
ENSMUSP00000359579
resolver
ensp
ENSMUSP00000359580
resolver
genesymbol
Mgrn1
resolver
genesymbol_syn
Kiaa0544
resolver
uniprot
Q3U5V9
resolver
uniprot
Q3UDA1
resolver
uniprot
Q6ZQ97
resolver
uniprot
Q8BZM9
resolver
uniprot_entry
MGRN1_MOUSE
resolver
uniprot_sec
Q3U5V9
resolver
uniprot_sec
Q3UDA1
resolver
uniprot_sec
Q6ZQ97
resolver
uniprot_sec
Q8BZM9
resolver
amino_acid_sequence
MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKEDADSPTEDGEKPRVLYSLEFTFDADARVAITIYCQAVEELVNGVAVYSCKNPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHVDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSSECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPISFSPVLAQSVDHDEHSSSDSIPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAGLDRIMESGLQKGKTQSKSPDSTLRSPSFPIHEEDEEKLSEDSDAPLPPSGVELVLRESSSPESFGTEEGDEPSLKQGSRVPSIDDVLQDGSPQHHGCSQPVPPADIYLPALGPESCSVGIEE
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination (By similarity). Also acts as a negative regulator of hedgehog signaling (PubMed:29290584). {ECO:0000250, ECO:0000269|PubMed:12560552, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:29290584}.
uniprot
proteins
mass_dalton
58477
uniprot
proteins
mutagenesis
MUTAGEN 278..281; /note="CVVC->AVVA: Loss of ubiquitin-protein ligase activity. Increase in TSG101-binding."; /evidence="ECO:0000269|PubMed:19703557"; MUTAGEN 384..387; /note="PSAP->ASAA: Loss of TSG101-binding."; /evidence="ECO:0000269|PubMed:19703557
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated in vitro. {ECO:0000269|PubMed:12560552}.
uniprot
proteins
pubmed
12438443
uniprot
proteins
pubmed
12560552
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17075880
uniprot
proteins
pubmed
17083490
uniprot
proteins
pubmed
17720281
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19422019
uniprot
proteins
pubmed
19524515
uniprot
proteins
pubmed
19703557
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29290584
uniprot
proteins
sequence_length
532
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:19422019, ECO:0000269|PubMed:19524515}. Note=The endosomal localization is dependent on the interaction with TSG101. {ECO:0000250|UniProtKB:O60291}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Cell membrane {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm. Nucleus. Note=In the cytoplasm, predominantly localized to the perinuclear region and discrete vesicular structures. In the nucleus, broadly distributed, but excluded from nucleoli.
uniprot
proteins