SLC6A15
entrez
55117
canonical
uniprot
Q9H2J7
canonical
ensembl
ENSG00000072041
resolver
ensp
ENSP00000266682
resolver
ensp
ENSP00000390706
resolver
ensp
ENSP00000450145
resolver
ensp
ENSP00000505134
resolver
ensp
ENSP00000695310
resolver
enst
ENST00000679989
resolver
genesymbol
SLC6A15
resolver
genesymbol_syn
B0AT2
resolver
genesymbol_syn
NTT73
resolver
genesymbol_syn
SBAT1
resolver
hgnc
HGNC:13621
resolver
uniprot
A0A7P0T8I1
resolver
uniprot
A8K592
resolver
uniprot
B7Z2P7
resolver
uniprot
E7ESJ5
resolver
uniprot
Q8IXG2
resolver
uniprot
Q9H9F5
resolver
uniprot
Q9NW50
resolver
uniprot_entry
A0A7P0T8I1_HUMAN
resolver
uniprot_entry
Q8IXG2_HUMAN
resolver
uniprot_entry
Q9NW50_HUMAN
resolver
uniprot_entry
S6A15_HUMAN
resolver
uniprot_sec
A8K592
resolver
uniprot_sec
B7Z2P7
resolver
uniprot_sec
E7ESJ5
resolver
uniprot_sec
Q9H9F5
resolver
amino_acid_sequence
MPKNSKVVKRELDDDVTESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPALHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDDSSGNLASVTYKRGRVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMADIMPDMPESDL
uniprot
proteins
function
FUNCTION: Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269|PubMed:16226721}.
uniprot
proteins
mass_dalton
81836
uniprot
proteins
protein_family
SLC6A15 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
11112352
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16226721
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
730
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:16226721}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 70..90; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 98..117; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 226..244; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 253..270; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 306..323; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 335..356; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 453..472; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 496..514; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 530..550; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 571..592; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 620..642; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins