Slamf1
entrez
27218
canonical
uniprot
Q9QUM4
canonical
ensembl
ENSMUSG00000015316
resolver
ensp
ENSMUSP00000015460
resolver
genesymbol
Slamf1
resolver
genesymbol_syn
Slam
resolver
uniprot
Q544K1
resolver
uniprot
Q8CAU4
resolver
uniprot
Q9QXZ3
resolver
uniprot_entry
Q544K1_MOUSE
resolver
uniprot_entry
Q8CAU4_MOUSE
resolver
uniprot_entry
SLAF1_MOUSE
resolver
uniprot_sec
Q9QXZ3
resolver
amino_acid_sequence
MDPKGSLSWRILLFLSLAFELSYGTGGGVMDCPVILQKLGQDTWLPLTNEHQINKSVNKSVRILVTMATSPGSKSNKKIVSFDLSKGSYPDHLEDGYHFQSKNLSLKILGNRRESEGWYLVSVEENVSVQQFCKQLKLYEQVSPPEIKVLNKTQENENGTCSLLLACTVKKGDHVTYSWSDEAGTHLLSRANRSHLLHITLSNQHQDSIYNCTASNPVSSISRTFNLSSQACKQESSSESSPWMQYTLVPLGVVIIFILVFTAIIMMKRQGKSNHCQPPVEEKSLTIYAQVQKSGPQEKKLHDALTDQDPCTTIYVAATEPAPESVQEPNPTTVYASVTLPES
uniprot
proteins
function
FUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (By similarity). However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (By similarity). Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (PubMed:12351401, PubMed:9126961). Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (PubMed:11477403, PubMed:15539155, PubMed:16847311). Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells (PubMed:15123745). Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells (PubMed:11477403). Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (PubMed:20525889). May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (By similarity). May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (PubMed:16528012). In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (PubMed:18031695). Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (PubMed:18606638). In macrophages involved in down-regulation of IL-12, TNF and nitric oxide in response to lipopolysaccharide (LPS) (PubMed:15123745). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (PubMed:15315965). In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (PubMed:25926831). {ECO:0000250|UniProtKB:Q13291, ECO:0000269|PubMed:11477403, ECO:0000269|PubMed:15123745, ECO:0000269|PubMed:15315965, ECO:0000269|PubMed:15539155, ECO:0000269|PubMed:16528012, ECO:0000269|PubMed:16847311, ECO:0000269|PubMed:18031695, ECO:0000269|PubMed:18606638, ECO:0000269|PubMed:25926831, ECO:0000269|PubMed:9126961}.; FUNCTION: (Microbial infection) Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulated of PdtIns(3)P and NOX2 activity in the phagosomes (PubMed:20818396, PubMed:22493499). {ECO:0000269|PubMed:20818396, ECO:0000305|PubMed:22493499}.
uniprot
proteins
mass_dalton
38094
uniprot
proteins
mutagenesis
MUTAGEN 288; /note="Y->A: Greatly reduces SLAMF1:SH2D1A-mediated intracellular tyrosine phosphorylation."; /evidence="ECO:0000269|PubMed:11477403"; MUTAGEN 315; /note="Y->A: Abolishes SLAMF1:SH2D1A-mediated intracellular tyrosine phosphorylation, no effect on interaction with SH2D1A; when associated with A-335."; /evidence="ECO:0000269|PubMed:11477403"; MUTAGEN 335; /note="Y->A: Abolishes SLAMF1:SH2D1A-mediated intracellular tyrosine phosphorylation, no effect on interaction with SH2D1A; when associated with A-315."; /evidence="ECO:0000269|PubMed:11477403
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by FYN (By similarity). {ECO:0000250|UniProtKB:Q13291, ECO:0000269|PubMed:11477403}.
uniprot
proteins
pubmed
10570270
uniprot
proteins
pubmed
11477403
uniprot
proteins
pubmed
11689425
uniprot
proteins
pubmed
12351401
uniprot
proteins
pubmed
15123745
uniprot
proteins
pubmed
15315965
uniprot
proteins
pubmed
15539155
uniprot
proteins
pubmed
16528012
uniprot
proteins
pubmed
16847311
uniprot
proteins
pubmed
18031695
uniprot
proteins
pubmed
18606638
uniprot
proteins
pubmed
20525889
uniprot
proteins
pubmed
20818396
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22493499
uniprot
proteins
pubmed
25926831
uniprot
proteins
pubmed
9126961
uniprot
proteins
pubmed
9774102
uniprot
proteins
sequence_length
343
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13291}; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells. Located at the plasma membrane contacts between neighboring T cells. {ECO:0000250|UniProtKB:Q13291}.
uniprot
proteins
transmembrane_region
TRANSMEM 243..265; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins