Gps2
entrez
56310
canonical
uniprot
Q921N8
canonical
ensembl
ENSMUSG00000023170
resolver
ensp
ENSMUSP00000054072
resolver
ensp
ENSMUSP00000072389
resolver
ensp
ENSMUSP00000112062
resolver
ensp
ENSMUSP00000201635
resolver
enst
ENSMUST00000057884
resolver
enst
ENSMUST00000072581
resolver
enst
ENSMUST00000116358
resolver
genesymbol
Gps2
resolver
uniprot_entry
GPS2_MOUSE
resolver
amino_acid_sequence
MPALLERPKLSNAMARALHRHIMMERERKRQEEEEVDKMMEQKMKEEQERRKKKEMEERMSLEETKEQILKLQEKLSALQEEKHQLFLQLKKVLHEEEKRRRKEQSDLTTLTSAAYQQSLTVHTGTHLLSMQGSPGGHNRPGTLMAADRAKQMFGPQVLTTRHYVGSAAAFAGTPEHGQFQGSPGGAYGTAQPPPHYGPTQPAYSPSQQLRAPSAFPAVQYLSQPQPQPYAVHGHFQPTQTGFLQPGSTLSLQKQMEHANQQTSFSDSSSLRPMHPQALHPAPGLLASPQLPVQIQAAGKSGFATTSQPGPRLPFIQHSQNPRFYHK
uniprot
proteins
function
FUNCTION: Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination (PubMed:22424771, PubMed:24953653, PubMed:28039360, PubMed:28123943, PubMed:29499132). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:18218630, PubMed:24953653, PubMed:25519902, PubMed:27270589, PubMed:28039360). Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (PubMed:22666460, PubMed:24953653). Promotes cholesterol efflux by acting as a transcription coactivator (By similarity). Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (PubMed:28039360). Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes (PubMed:29499132). Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13 (PubMed:29499132). Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG (PubMed:25519902). Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor (PubMed:27270589). Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation (By similarity). In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways (PubMed:22424771, PubMed:28123943). In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the pro-inflammatory TNF pathway; acts by repressing UBE2N/Ubc13 activity (PubMed:22424771). In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13-mediated ubiquitination of AKT (PubMed:28123943). Able to suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction (By similarity). {ECO:0000250|UniProtKB:Q13227, ECO:0000269|PubMed:18218630, ECO:0000269|PubMed:22424771, ECO:0000269|PubMed:22666460, ECO:0000269|PubMed:24953653, ECO:0000269|PubMed:25519902, ECO:0000269|PubMed:27270589, ECO:0000269|PubMed:28039360, ECO:0000269|PubMed:28123943, ECO:0000269|PubMed:29499132}.
uniprot
proteins
mass_dalton
36738
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="K->R: Decreased stability of the protein, probably due inability to interact with TBL1X; when associated with R-71. Abolishes sumoylation; when associated with R-71."; /evidence="ECO:0000269|PubMed:29499132"; MUTAGEN 52..53; /note="KK->AA: Does not affect localization to the nucleus."; /evidence="ECO:0000269|PubMed:26070566"; MUTAGEN 71; /note="K->R: Decreased stability of the protein, probably due inability to interact with TBL1X; when associated with R-45. Abolishes sumoylation; when associated with R-45."; /evidence="ECO:0000269|PubMed:26070566, ECO:0000269|PubMed:29499132"; MUTAGEN 254; /note="K->A: Increased stability due to impaired ubiquitination; when associated with A-300 and A-327."; /evidence="ECO:0000269|PubMed:26070566"; MUTAGEN 300; /note="K->A: Increased stability due to impaired ubiquitination; when associated with A-254 and A-327."; /evidence="ECO:0000269|PubMed:26070566"; MUTAGEN 312; /note="R->A: Abolished methylation; when associated with A-323."; /evidence="ECO:0000269|PubMed:26070566"; MUTAGEN 323; /note="R->A: Promotes ubiquitination and degradation by the proteasome. Abolished methylation; when associated with A-312."; /evidence="ECO:0000269|PubMed:26070566"; MUTAGEN 327; /note="K->A: Increased stability due to impaired ubiquitination; when associated with A-254 and A-300."; /evidence="ECO:0000269|PubMed:26070566
uniprot
proteins
post_translational_modification
PTM: Sumoylation regulates its subcellular location (PubMed:26070566, PubMed:29499132). Sumoylation at Lys-45 and Lys-71 regulates the shuttling between the cytoplasm and the nucleus (By similarity). Sumoylation at Lys-71 is required for interaction with TBL1X (PubMed:26070566). Sumoylated at Lys-45 and Lys-71 in mitochondrion (PubMed:29499132). Desumoylation by SENP1 leads to relocation from the mitochondria to the nucleus (PubMed:29499132). {ECO:0000250|UniProtKB:Q13227, ECO:0000269|PubMed:26070566, ECO:0000269|PubMed:29499132}.; PTM: Ubiquitinated at the C-terminus by SIAH2; leading to its degradation by the proteasome. Interaction with TBL1X and methylation at Arg-323 protect GPS2 against ubiquitination and degradation. {ECO:0000269|PubMed:26070566}.; PTM: Methylated at Arg-312 and Arg-323 by PRMT6. Methylation at Arg-323 protects from degradation by the proteasome. {ECO:0000269|PubMed:26070566}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18218630
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22424771
uniprot
proteins
pubmed
22666460
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24953653
uniprot
proteins
pubmed
25519902
uniprot
proteins
pubmed
26070566
uniprot
proteins
pubmed
27270589
uniprot
proteins
pubmed
28039360
uniprot
proteins
pubmed
28123943
uniprot
proteins
pubmed
29499132
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18218630, ECO:0000269|PubMed:22424771, ECO:0000269|PubMed:22666460, ECO:0000269|PubMed:26070566, ECO:0000269|PubMed:29499132}. Mitochondrion {ECO:0000269|PubMed:29499132}. Cytoplasm, cytosol {ECO:0000269|PubMed:22424771}. Note=Sumoylation regulates the subcellular location (PubMed:29499132). Relocates from the mitochondria to the nucleus following desumoylation, leading to mediate mitochondrial stress response (PubMed:29499132). {ECO:0000250|UniProtKB:Q13227, ECO:0000269|PubMed:29499132}.
uniprot
proteins