EIF4A1
entrez
1973
canonical
uniprot
P60842
canonical
ensembl
ENSG00000161960
resolver
ensp
ENSP00000293831
resolver
ensp
ENSP00000463486
resolver
genesymbol
EIF4A1
resolver
genesymbol_syn
DDX2A
resolver
genesymbol_syn
EIF4A
resolver
hgnc
HGNC:3282
resolver
uniprot
B2R6L8
resolver
uniprot
D3DTP9
resolver
uniprot
J3QLC4
resolver
uniprot
P04765
resolver
uniprot
Q5U018
resolver
uniprot
Q61516
resolver
uniprot_entry
IF4A1_HUMAN
resolver
uniprot_sec
B2R6L8
resolver
uniprot_sec
D3DTP9
resolver
uniprot_sec
J3QLC4
resolver
uniprot_sec
P04765
resolver
uniprot_sec
Q5U018
resolver
uniprot_sec
Q61516
resolver
activity_regulation
ACTIVITY REGULATION: Helicase activity and function in translation are inhibited by interaction with PDCD4. {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}.
uniprot
proteins
amino_acid_sequence
MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20156963}.
uniprot
proteins
mass_dalton
46154
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
protein_family
eIF4A subfamily
uniprot
proteins
pubmed
11073994
uniprot
proteins
pubmed
11408474
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15282546
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15715967
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17284590
uniprot
proteins
pubmed
18596238
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19153607
uniprot
proteins
pubmed
19204291
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20133758
uniprot
proteins
pubmed
20156963
uniprot
proteins
pubmed
20941364
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23444369
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
37316325
uniprot
proteins
pubmed
39349455
uniprot
proteins
pubmed
8493113
uniprot
proteins
pubmed
9548260
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:20156963}. Cell membrane {ECO:0000269|PubMed:20156963}. Cytoplasm, Stress granule {ECO:0000269|PubMed:20156963}. Note=Colocalizes with PKP1 in stress granules following arsenate or hydrogen peroxide treatment. {ECO:0000269|PubMed:20156963}.
uniprot
proteins