Jak3
entrez
16453
canonical
uniprot
Q62137
canonical
ensembl
ENSMUSG00000031805
resolver
ensp
ENSMUSP00000060073
resolver
ensp
ENSMUSP00000105639
resolver
ensp
ENSMUSP00000105640
resolver
enst
ENSMUST00000051995
resolver
enst
ENSMUST00000110012
resolver
enst
ENSMUST00000110013
resolver
genesymbol
Jak3
resolver
uniprot
A0A0R4J0R7
resolver
uniprot
A2RRI3
resolver
uniprot
Q0D2M8
resolver
uniprot
Q61746
resolver
uniprot
Q61747
resolver
uniprot
Q8BTY6
resolver
uniprot
Q8BYU2
resolver
uniprot_entry
A0A0R4J0R7_MOUSE
resolver
uniprot_entry
JAK3_MOUSE
resolver
uniprot_sec
A2RRI3
resolver
uniprot_sec
Q0D2M8
resolver
uniprot_sec
Q61746
resolver
uniprot_sec
Q61747
resolver
uniprot_sec
Q8BTY6
resolver
uniprot_sec
Q8BYU2
resolver
amino_acid_sequence
MAPPSEETPLIPQRSCSLSSSEAGALHVLLPPRGPGPPQRLSFSFGDYLAEDLCVRAAKACGILPVYHSLFALATEDFSCWFPPSHIFCIEDVDTQVLVYRLRFYFPDWFGLETCHRFGLRKDLTSAILDLHVLEHLFAQHRSDLVSGRLPVGLSMKEQGEFLSLAVLDLAQMAREQAQRPGELLKTVSYKACLPPSLRDVIQGQNFVTRRRIRRTVVLALRRVVACQADRYALMAKYILDLERLHPAATTETFRVGLPGAQEEPGLLRVAGDNGISWSSGDQELFQTFCDFPEIVDVSIKQAPRVGPAGEHRLVTVTRMDGHILEAEFPGLPEALSFVALVDGYFRLICDSRHYFCKEVAPPRLLEEEAELCHGPITLDFAIHKLKAAGSLPGTYILRRSPQDYDSFLLTACVQTPLGPDYKGCLIRQDPSGAFSLVGLSQPHRSLRELLAACWNSGLRVDGAALNLTSCCAPRPKEKSNLIVVRRGCTPAPAPGCSPSCCALTQLSFHTIPTDSLEWHENLGHGSFTKIFRGRRREVVDGETHDSEVLLKVMDSRHRNCMESFLEAASLMSQVSYPHLVLLHGVCMAGDSIMVQEFVYLGAIDMYLRKRGHLVSASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGGDGNPPFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLQEAQTLCLEADKWGFGATTWEVFSGGPAHITSLEPAKKLKFYEDQGQLPALKWTELAGLITQCMAYDPGRRPSFRAILRDLNGLITSDYELLSDPTPGIPSPRDELCGGAQLYACQDPAIFEERHLKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLHTDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAKLLPLGKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGPEREGPPLCRLLELLAEGRRLPPPPTCPTEVQELMQLCWAPSPHDRPAFGTLSPQLDALWRGRPG
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation (PubMed:20696842). Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. {ECO:0000269|PubMed:20696842, ECO:0000269|PubMed:9016869}.
uniprot
proteins
mass_dalton
122641
uniprot
proteins
mutagenesis
MUTAGEN 853; /note="L->R: Loss of activity."; /evidence="ECO:0000269|PubMed:8605329
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated, leading to regulate its activity. IL2 promotes phosphorylation on tyrosine residues, including autophosphorylation on Tyr-781 (By similarity). Dephosphorylation of Tyr-976 and Tyr-977 by PTPN2 negatively regulates cytokine-mediated signaling (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
JAK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10733938
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20696842
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7481767
uniprot
proteins
pubmed
7481769
uniprot
proteins
pubmed
7518579
uniprot
proteins
pubmed
8022486
uniprot
proteins
pubmed
8605329
uniprot
proteins
pubmed
9016869
uniprot
proteins
pubmed
9620658
uniprot
proteins
sequence_length
1100
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
uniprot
proteins