TRIM59
entrez
286827
canonical
uniprot
Q8IWR1
canonical
ensembl
ENSG00000213186
resolver
ensp
ENSP00000311219
resolver
ensp
ENSP00000540940
resolver
ensp
ENSP00000540941
resolver
ensp
ENSP00000540942
resolver
ensp
ENSP00000587050
resolver
ensp
ENSP00000587051
resolver
ensp
ENSP00000587052
resolver
ensp
ENSP00000587053
resolver
ensp
ENSP00000587054
resolver
ensp
ENSP00000587055
resolver
ensp
ENSP00000587056
resolver
enst
ENST00000309784
resolver
enst
ENST00000870881
resolver
enst
ENST00000870882
resolver
enst
ENST00000870883
resolver
enst
ENST00000916991
resolver
enst
ENST00000916992
resolver
enst
ENST00000916993
resolver
enst
ENST00000916994
resolver
enst
ENST00000916995
resolver
enst
ENST00000916996
resolver
enst
ENST00000916997
resolver
genesymbol
TRIM59
resolver
genesymbol_syn
RNF104
resolver
genesymbol_syn
TRIM57
resolver
genesymbol_syn
TSBF1
resolver
hgnc
HGNC:30834
resolver
uniprot
A8K5G9
resolver
uniprot
D3DNL9
resolver
uniprot_entry
TRI59_HUMAN
resolver
uniprot_sec
A8K5G9
resolver
uniprot_sec
D3DNL9
resolver
amino_acid_sequence
MHNFEEELTCPICYSIFEDPRVLPCSHTFCRNCLENILQASGNFYIWRPLRIPLKCPNCRSITEIAPTGIESLPVNFALRAIIEKYQQEDHPDIVTCPEHYRQPLNVYCLLDKKLVCGHCLTIGQHHGHPIDDLQSAYLKEKDTPQKLLEQLTDTHWTDLTHLIEKLKEQKSHSEKMIQGDKEAVLQYFKELNDTLEQKKKSFLTALCDVGNLINQEYTPQIERMKEIREQQLELMALTISLQEESPLKFLEKVDDVRQHVQILKQRPLPEVQPVEIYPRVSKILKEEWSRTEIGQIKNVLIPKMKISPKRMSCSWPGKDEKEVEFLKILNIVVVTLISVILMSILFFNQHIITFLSEITLIWFSEASLSVYQSLSNSLHKVKNILCHIFYLLKEFVWKIVSH
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase involved in different processes such as development and immune response (PubMed:22588174, PubMed:30231667). Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT (PubMed:22588174). Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1 (PubMed:30231667). On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway. On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex. In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation (PubMed:30231667). Also acts as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'-linked ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q922Y2, ECO:0000269|PubMed:22588174, ECO:0000269|PubMed:30231667}.
uniprot
proteins
mass_dalton
47114
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18601909
uniprot
proteins
pubmed
22588174
uniprot
proteins
pubmed
30231667
uniprot
proteins
sequence_length
403
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22588174}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 329..349; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins