DGAT2
entrez
84649
canonical
uniprot
Q96PD7
canonical
ensembl
ENSG00000062282
resolver
ensp
ENSP00000228027
resolver
ensp
ENSP00000365438
resolver
genesymbol
DGAT2
resolver
hgnc
HGNC:16940
resolver
uniprot
A6ND76
resolver
uniprot
Q5U810
resolver
uniprot
Q68CL3
resolver
uniprot
Q68DJ0
resolver
uniprot
Q8NDB7
resolver
uniprot
Q96BS0
resolver
uniprot
Q9BYE5
resolver
uniprot_entry
DGAT2_HUMAN
resolver
uniprot_sec
A6ND76
resolver
uniprot_sec
Q5U810
resolver
uniprot_sec
Q68CL3
resolver
uniprot_sec
Q68DJ0
resolver
uniprot_sec
Q8NDB7
resolver
uniprot_sec
Q96BS0
resolver
uniprot_sec
Q9BYE5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by niacin. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
uniprot
proteins
ec_number
2.3.1.20
uniprot
proteins
ec_number
2.3.1.76
uniprot
proteins
function
FUNCTION: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (PubMed:27184406). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Also functions as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {ECO:0000250|UniProtKB:Q9DCV3, ECO:0000269|PubMed:27184406, ECO:0000269|PubMed:28420705}.
uniprot
proteins
mass_dalton
43831
uniprot
proteins
pathway_participation
PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis. {ECO:0000269|PubMed:27184406}.
uniprot
proteins
protein_family
Diacylglycerol acyltransferase family
uniprot
proteins
pubmed
11481335
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14521909
uniprot
proteins
pubmed
15221005
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16214399
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18768481
uniprot
proteins
pubmed
26786738
uniprot
proteins
pubmed
27184406
uniprot
proteins
pubmed
28420705
uniprot
proteins
pubmed
30970241
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14521909, ECO:0000269|PubMed:27184406}; Multi-pass membrane protein {ECO:0000269|PubMed:14521909}. Lipid droplet {ECO:0000269|PubMed:27184406}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27184406}.
uniprot
proteins
transmembrane_region
TRANSMEM 70..88; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..112; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins