Tsen2
entrez
312649
canonical
uniprot
Q5M954
canonical
ensembl
ENSRNOG00000060175
resolver
ensembl
ENSRNOG00055009167
resolver
ensembl
ENSRNOG00060025995
resolver
ensembl
ENSRNOG00065029073
resolver
ensp
ENSRNOP00000073692
resolver
ensp
ENSRNOP00055012433
resolver
ensp
ENSRNOP00060037398
resolver
ensp
ENSRNOP00065041281
resolver
enst
ENSRNOT00000081957
resolver
enst
ENSRNOT00055015518
resolver
enst
ENSRNOT00060045077
resolver
enst
ENSRNOT00065050259
resolver
genesymbol
Tsen2
resolver
uniprot_entry
SEN2_RAT
resolver
amino_acid_sequence
MAEAVFRAPKRKRRVYESYESPLPIPFSQDQSPRKEFRIFQAEMISNNVVVRGTEDMEQLYGKGYFGKGILSRSRPNFTISNPKLAARWKGVQTDMPIITSEKYQHRVEWARDFMRRQGHDESTVQKILTDYTEPLEPPYRERKGESPQHEPLSSKADSSLEGREGKDELSVTTGGAGQSDDLQGLNTHSDCRQEGPGHATLTVASPSSLNGHAIEDPEALSQIPCCSQEALGQQDDLWPEASSQIAGESRAAHEYVLIEEELCDVQEGAAPHDELLKRKRLVCRRNPYRIFEYLQLSLEEAFFLAYALGCLSIYYEKEPLTIVKLWQAFTAVQPTFRTTYMAYHYFRSKGWVPKVGLKYGTDLLLYRKGPPFYHASYSVIIELVDDNFEGSLRRPFSWKSLAALSRVSGNVSKELMLCYLIKPSTMTNEDMETPECMRRIQVQEVILSRWVSSRERSDQDEL
uniprot
proteins
ec_number
4.6.1.16
uniprot
proteins
function
FUNCTION: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
52952
uniprot
proteins
protein_family
TRNA-intron endonuclease family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=May be transiently localized in the nucleolus. {ECO:0000250}.
uniprot
proteins