Cfap45
entrez
71870
canonical
uniprot
Q9D9U9
canonical
ensembl
ENSMUSG00000026546
resolver
ensp
ENSMUSP00000083057
resolver
enst
ENSMUST00000085894
resolver
genesymbol
Cfap45
resolver
genesymbol_syn
Ccdc19
resolver
genesymbol_syn
Nesg1
resolver
uniprot_entry
CFA45_MOUSE
resolver
amino_acid_sequence
MPLRPGDASSSASTASNRSRTRTRYRTKAMNSEVDESLFGGVKPSSQGKSDSPIVVIHDKHAIRKTLSALGLEHKTETIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASQVLTKEELNAREQALKKEKEGILEAVTIRKKIMKQKEMTWNNNKKLSDLEEVARERAQNLLQRADKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDEEERRLDHMMEIDRRESLQRQEDRERKRREERVRGKRHIVEQIKKNEEERSLQAEHREQEKEQMLAYLDRLQEEDLQDLERRHQEKLKMQAEIKRINDENQRQKAEMLAQERLADQMVMEFTKKKMAREAEYEAEQEKIRREKEKEIARLRALQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENAQKKIETEEKLRKSRLEQVAFKEHTLAVQVQRDRDEFERILRAQREQIEREKQEQEKKAKGCLQHANELRRQVRENQQKHVQNRLATFEEGRRLKEEAEKRRERIEDIKKQKLEELRATGLPEKYCIEVERKANILPATSVN
uniprot
proteins
function
FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:37295417, PubMed:37865089, PubMed:37989994). It is an AMP-binding protein that may facilitate dynein ATPase-dependent ciliary and flagellar beating via adenine nucleotide homeostasis (By similarity). May function as a donor of AMP to AK8 and hence promote ADP production (PubMed:33139725). {ECO:0000250|UniProtKB:Q32LN4, ECO:0000269|PubMed:33139725, ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37865089, ECO:0000269|PubMed:37989994}.
uniprot
proteins
mass_dalton
65826
uniprot
proteins
protein_family
CFAP45 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
33139725
uniprot
proteins
pubmed
37295417
uniprot
proteins
pubmed
37865089
uniprot
proteins
pubmed
37989994
uniprot
proteins
sequence_length
551
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:33139725}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:33139725, ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37865089, ECO:0000269|PubMed:37989994}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9UL16}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9UL16}. Note=Located in the proximal region of respiratory cilia. {ECO:0000269|PubMed:33139725}.
uniprot
proteins