O88667
uniprot
O88667
canonical
amino_acid_sequence
MTLNGGSGASGSRGAGGRERDRRRGSTPWGPAPPLHRRSMPVDERDLQAALAPGSLATTAAGTRTQGQRLDWPEGSSDSLSSGGSGSEEGVYKVLLLGAPGVGKSALARIFGGIEDGPEAEAAGHTYDRSITVDGEEASLLVYDIWEEDGGCWLPGHCMAMGDAYVIVYSITDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEDNARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL
uniprot
proteins
function
FUNCTION: May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-dependent L-type Ca(2+) currents (PubMed:17525370). Regulates voltage-gated L-type calcium channel subunit alpha-1C trafficking to the cell membrane (PubMed:17525370). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway (PubMed:18056528). Inhibits phosphorylation and activation of CAMK2D (By similarity). {ECO:0000250|UniProtKB:P55042, ECO:0000269|PubMed:17525370, ECO:0000269|PubMed:18056528, ECO:0000269|PubMed:36424916}.
uniprot
proteins
mass_dalton
33279
uniprot
proteins
mutagenesis
MUTAGEN 26; /note="S->A: Reduces amplitude of peak Ca(2+) current induced in ventricular and atrial cardiomyocytes by nonselective beta-adrenoreceptor agonist isoproterenol; however, basal electrophysiological properties of Ca(2+) channels did not differ; when associated with A-39; A-273 and A-301."; /evidence="ECO:0000269|PubMed:36424916"; MUTAGEN 39; /note="S->A: Reduces amplitude of peak Ca(2+) current induced in ventricular and atrial cardiomyocytes by nonselective beta-adrenoreceptor agonist isoproterenol; however, basal electrophysiological properties of Ca(2+) channels did not differ; when associated with A-26; A-273 and A-301."; /evidence="ECO:0000269|PubMed:36424916"; MUTAGEN 105; /note="S->A: Loss of interaction with CACNB2. QT prolongation and ventricular arrhythmias, caused by the augmentation of L-type Ca(2+) channels in the heart."; /evidence="ECO:0000269|PubMed:17525370"; MUTAGEN 273; /note="S->A: Reduces amplitude of peak Ca(2+) current induced in ventricular and atrial cardiomyocytes by nonselective beta-adrenoreceptor agonist isoproterenol; however, basal electrophysiological properties of Ca(2+) channels did not differ; when associated with A-26; A-39 and A-301."; /evidence="ECO:0000269|PubMed:36424916"; MUTAGEN 301; /note="S->A: Reduces amplitude of peak Ca(2+) current induced in ventricular and atrial cardiomyocytes by nonselective beta-adrenoreceptor agonist isoproterenol; however, basal electrophysiological properties of Ca(2+) channels did not differ; when associated with A-26; A-39 and A-273."; /evidence="ECO:0000269|PubMed:36424916
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-26, Ser-39, Ser-273 and Ser-301 may be involved in regulating inhibition of voltage-gated L-type Ca(2+) channels. {ECO:0000269|PubMed:36424916}.
uniprot
proteins
protein_family
RGK family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
17525370
uniprot
proteins
pubmed
18056528
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
36424916
uniprot
proteins
sequence_length
308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17525370}.
uniprot
proteins