Ostc
entrez
362040
canonical
uniprot
B0K025
canonical
ensembl
ENSRNOG00000023322
resolver
ensembl
ENSRNOG00055011493
resolver
ensembl
ENSRNOG00060002762
resolver
ensembl
ENSRNOG00065014405
resolver
ensp
ENSRNOP00000094880
resolver
ensp
ENSRNOP00055015752
resolver
ensp
ENSRNOP00060003100
resolver
ensp
ENSRNOP00065018518
resolver
enst
ENSRNOT00055019531
resolver
enst
ENSRNOT00060004405
resolver
enst
ENSRNOT00065023795
resolver
genesymbol
Ostc
resolver
genesymbol_syn
Dc2
resolver
uniprot_entry
OSTC_RAT
resolver
amino_acid_sequence
METLYRVPFLVLECPNLKLKKPPWVHMPSAMTVYALVVVSYFLITGGIIYDVIVEPPSVGSMTDEHGHQRPVAFLAYRVNGQYIMEGLASSFLFTMGGLGFIILDRSNAPNIPKLNRFLLLFIGFVCVLLSFFMARVFMRMKLPGYLMG
uniprot
proteins
function
FUNCTION: Subunit of STT3A-containing oligosaccharyl transferase (OST-A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. {ECO:0000250|UniProtKB:Q9NRP0}.
uniprot
proteins
mass_dalton
16815
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q9NRP0}.
uniprot
proteins
protein_family
OSTC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
149
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9NRP0}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..53; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins