SLC38A5
entrez
92745
canonical
uniprot
Q8WUX1
canonical
ensembl
ENSG00000017483
resolver
ensp
ENSP00000481291
resolver
ensp
ENSP00000545481
resolver
ensp
ENSP00000625914
resolver
ensp
ENSP00000733087
resolver
genesymbol
SLC38A5
resolver
genesymbol_syn
JM24
resolver
genesymbol_syn
SN2
resolver
genesymbol_syn
SNAT5
resolver
hgnc
HGNC:18070
resolver
uniprot
B3KT20
resolver
uniprot
B5MDE6
resolver
uniprot
B7WPJ9
resolver
uniprot
Q6PIW9
resolver
uniprot
Q8WYU2
resolver
uniprot
Q96PQ4
resolver
uniprot_entry
S38A5_HUMAN
resolver
uniprot_sec
B3KT20
resolver
uniprot_sec
B5MDE6
resolver
uniprot_sec
B7WPJ9
resolver
uniprot_sec
Q6PIW9
resolver
uniprot_sec
Q8WYU2
resolver
uniprot_sec
Q96PQ4
resolver
activity_regulation
ACTIVITY REGULATION: Not inhibited by lithium (PubMed:11243884). Partial allosteric regulation on ions sodium binding (By similarity). {ECO:0000250|UniProtKB:A2VCW5, ECO:0000269|PubMed:11243884}.
uniprot
proteins
amino_acid_sequence
MELQDPKMNGALPSDAVGYRQEREGFLPSRGPAPGSKPVQFMDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCAGIAGIRAYEQLGQRAFGPAGKVVVATVICLHNVGAMSSYLFIIKSELPLVIGTFLYMDPEGDWFLKGNLLIIIVSVLIILPLALMKHLGYLGYTSGLSLTCMLFFLVSVIYKKFQLGCAIGHNETAMESEALVGLPSQGLNSSCEAQMFTVDSQMSYTVPIMAFAFVCHPEVLPIYTELCRPSKRRMQAVANVSIGAMFCMYGLTATFGYLTFYSSVKAEMLHMYSQKDPLILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPGKAFSWPRHVAIALILLVLVNVLVICVPTIRDIFGVIGSTSAPSLIFILPSIFYLRIVPSEVEPFLSWPKIQALCFGVLGVLFMAVSLGFMFANWATGQSRMSGH
uniprot
proteins
function
FUNCTION: Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:11243884). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the NMDA receptors activation (By similarity). In addition, contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells therefore, participates in the retinal glutamate-glutamine cycle (By similarity). The transport activity is pH sensitive and Li(+) tolerant (PubMed:11243884). Moreover functions in both direction and is associated with large uncoupled fluxes of protons (By similarity). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). May have a particular importance for modulation of net hepatic glutamine flux (By similarity). {ECO:0000250|UniProtKB:A2VCW5, ECO:0000250|UniProtKB:Q3U1J0, ECO:0000269|PubMed:11243884}.
uniprot
proteins
mass_dalton
51457
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
pubmed
11243884
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
22814378
uniprot
proteins
sequence_length
472
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A2VCW5}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at astroglial membrane. {ECO:0000250|UniProtKB:A2VCW5}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..71; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 126..146; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 296..316; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 335..355; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 400..420; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 440..460; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins