TSTD1
entrez
100131187
canonical
uniprot
Q8NFU3
canonical
ensembl
ENSG00000215845
resolver
ensp
ENSP00000325518
resolver
ensp
ENSP00000357003
resolver
ensp
ENSP00000388293
resolver
genesymbol
TSTD1
resolver
genesymbol_syn
KAT
resolver
hgnc
HGNC:35410
resolver
uniprot
Q5SY48
resolver
uniprot
Q5SY49
resolver
uniprot
Q5SY50
resolver
uniprot
Q5SY51
resolver
uniprot
Q8NFU2
resolver
uniprot
Q9BV22
resolver
uniprot_entry
TSTD1_HUMAN
resolver
uniprot_sec
Q5SY48
resolver
uniprot_sec
Q5SY49
resolver
uniprot_sec
Q5SY50
resolver
uniprot_sec
Q5SY51
resolver
uniprot_sec
Q8NFU2
resolver
uniprot_sec
Q9BV22
resolver
activity_regulation
ACTIVITY REGULATION: GSS(-) is a potent inhibitor of TSTD1, since the presence of the sulfur dioxygenase (SDO) strongly increases the TSTD1 catalytic activity (PubMed:24981631). {ECO:0000269|PubMed:24981631}.
uniprot
proteins
amino_acid_sequence
MAGAPTVSLPELRSLLASGRARLFDVRSREEAAAGTIPGALNIPVSELESALQMEPAAFQALYSAEKPKLEDEHLVFFCQMGKRGLQATQLARSLGYTGARNYAGAYREWLEKES
uniprot
proteins
ec_number
2.8.1.3
uniprot
proteins
function
FUNCTION: Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631). GSS(-) spontaneously reacts with glutathione to form glutathione disulfide (Probable). {ECO:0000269|PubMed:24981631, ECO:0000305}.
uniprot
proteins
mass_dalton
12530
uniprot
proteins
mutagenesis
MUTAGEN 79; /note="C->A,S: Leads to the loss of catalytic activity."; /evidence="ECO:0000269|PubMed:24981631
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12817473
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24981631
uniprot
proteins
sequence_length
115
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12817473}. Note=Localized around the nuclear membranes.
uniprot
proteins