Fbxo28
entrez
67948
canonical
uniprot
Q8BIG4
canonical
ensembl
ENSMUSG00000047539
resolver
ensp
ENSMUSP00000054718
resolver
enst
ENSMUST00000051431
resolver
genesymbol
Fbxo28
resolver
genesymbol_syn
D1Ertd578e
resolver
genesymbol_syn
Kiaa0483
resolver
uniprot
Q3TS97
resolver
uniprot
Q7TMH9
resolver
uniprot
Q8BIF6
resolver
uniprot_entry
FBX28_MOUSE
resolver
uniprot_sec
Q3TS97
resolver
uniprot_sec
Q7TMH9
resolver
uniprot_sec
Q8BIF6
resolver
amino_acid_sequence
MAAASEERMAEEGGGGHGDGGSCSAAGSAQRQPPAPPSQAPPPGSQAPAAPALAPDHLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERFHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGSPPVPGPSAALTTMQLFSKQNPSRQEVTKLQQQVRTNGAGVTVLRREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGTSSGSGQSEESPRKRRKATEAIDSLRKSKRLRNRK
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, promoting ubiquitination and proteasomal degradation of specific target proteins including TOP2A, RAB27A or itself. Regulates topoisomerase IIalpha/TOP2A decatenation activity and plays an important role in maintaining genomic stability (By similarity). Plays a role in lipid metabolism and inflammation through the ubiquitinated degradation of RAB27A (PubMed:38696123). Strongly regulates beta-cell survival without having any significant independent effect on insulin secretion (By similarity). Plays an essential role in spindle morphology and actin-based spindle migration probably through the ARPC2/ARP3 signaling pathway (PubMed:38960234). {ECO:0000250|UniProtKB:Q9NVF7, ECO:0000269|PubMed:38696123, ECO:0000269|PubMed:38960234}.
uniprot
proteins
mass_dalton
40978
uniprot
proteins
post_translational_modification
PTM: Degraded through self-ubiquitination. {ECO:0000250|UniProtKB:Q9NVF7}.
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
38696123
uniprot
proteins
pubmed
38960234
uniprot
proteins
sequence_length
368
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9NVF7}. Nucleus {ECO:0000269|PubMed:38696123, ECO:0000269|PubMed:38960234}. Chromosome {ECO:0000269|PubMed:38960234}.
uniprot
proteins