Crym
entrez
12971
canonical
uniprot
O54983
canonical
ensembl
ENSMUSG00000030905
resolver
ensp
ENSMUSP00000033198
resolver
enst
ENSMUST00000033198
resolver
genesymbol
Crym
resolver
uniprot
Q3UPX0
resolver
uniprot_entry
CRYM_MOUSE
resolver
uniprot_entry
Q3UPX0_MOUSE
resolver
amino_acid_sequence
MKRAPAFLSAEEVQDHLRSSSLLIPPLEAALANFSKGPDGGVMQPVRTVVPVAKHRGFLGVMPAYSAAEDALTTKLVTFYEGHSNTAVPSHQASVLLFDPSNGSLLAVMDGNVITAKRTAAVSAIATKLLKPPGSDVLCILGAGVQAYSHYEIFTEQFSFKEVRMWNRTRENAEKFASTVQGDVRVCSSVQEAVTGADVIITVTMATEPILFGEWVKPGAHINAVGASRPDWRELDDELMRQAVLYVDSREAALKESGDVLLSGADIFAELGEVISGAKPAHCEKTTVFKSLGMAVEDLVAAKLVYDSWSSGK
uniprot
proteins
ec_number
1.5.1.1
uniprot
proteins
ec_number
1.5.1.25
uniprot
proteins
function
FUNCTION: Catalyzes the NAD(P)H-dependent reduction of imine double bonds of a number of cyclic ketimine substrates, including sulfur-containing cyclic ketimines. Under physiological conditions, it efficiently catalyzes delta(1)-piperideine-2-carboxylate (P2C) and delta(1)-pyrroline-2-carboxylate (Pyr2C) reduction, suggesting a central role in lysine and glutamate metabolism. Additional substrates are delta(2)-thiazoline-2-carboxylate (T2C), 3,4-dehydrothiomorpholine-3-carboxylate (AECK), and (R)-lanthionine ketimine (LK) that is reduced at very low rate compared to other substrates (By similarity). Also catalyzes the NAD(P)H-dependent reduction of (S)-cystathionine ketimine (CysK) (By similarity). {ECO:0000250|UniProtKB:Q14894, ECO:0000250|UniProtKB:Q2KHX6}.
uniprot
proteins
mass_dalton
33523
uniprot
proteins
protein_family
Ornithine cyclodeaminase/mu-crystallin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16740909
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24467707
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14894}.
uniprot
proteins