Klhdc2
entrez
69554
canonical
uniprot
Q4G5Y1
canonical
ensembl
ENSMUSG00000020978
resolver
ensp
ENSMUSP00000021362
resolver
enst
ENSMUST00000021362
resolver
genesymbol
Klhdc2
resolver
uniprot
E9QKN6
resolver
uniprot
Q99JY2
resolver
uniprot
Q9D784
resolver
uniprot_entry
KLDC2_MOUSE
resolver
uniprot_sec
E9QKN6
resolver
uniprot_sec
Q99JY2
resolver
uniprot_sec
Q9D784
resolver
amino_acid_sequence
MADGNEDARAEDLPGPAFENYEAMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSADRGLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFAWSQPITTGKAPSPRAAHACATVGNKGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGVCPVGRSWHSLTPVSSDHLFLFGGFTTEKQPLSDAWTYCISKNEWIQFNHPYVEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEVLIFSVQPKSLVRLSLEAVICFKEMLANSWSCLPKHLLHSVNQRFGSNNTSGS
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(KLHDC2) complex specifically recognizes proteins with a diglycine (Gly-Gly) at the C-terminus, leading to their ubiquitination and degradation (By similarity). The CRL2(KLHDC2) complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine (By similarity). The CRL2(KLHDC2) complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation (By similarity). May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding (By similarity). {ECO:0000250|UniProtKB:Q9Y2U9}.
uniprot
proteins
mass_dalton
45909
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9Y2U9}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated by the CRL2(KLHDC2) E3 ligase complex. {ECO:0000250|UniProtKB:Q9Y2U9}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16008511
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y2U9}.
uniprot
proteins