SNX4
entrez
8723
canonical
uniprot
O95219
canonical
ensembl
ENSG00000114520
resolver
ensp
ENSP00000251775
resolver
ensp
ENSP00000543429
resolver
genesymbol
SNX4
resolver
hgnc
HGNC:11175
resolver
uniprot
B3KMH0
resolver
uniprot
B4DQV4
resolver
uniprot
D3DNA3
resolver
uniprot_entry
SNX4_HUMAN
resolver
uniprot_sec
B3KMH0
resolver
uniprot_sec
B4DQV4
resolver
uniprot_sec
D3DNA3
resolver
amino_acid_sequence
MEQAPPDPERQLQPAPLEPLGSPDAGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYLIETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNWKETVNETGFQLKADSRLKALNATFRVKNPDKRFTDLKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILEDEEHYADQLKEYLFYAEALRAVCRKHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLEEQINEGEQQLKSKNLEGREFVKNAWADIERFKEQKNRDLKEALISYAVMQISMCKKGIQVWTNAKECFSKM
uniprot
proteins
function
FUNCTION: Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730, PubMed:17994011, PubMed:32513819, PubMed:33468622). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (PubMed:17994011). Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A (PubMed:32513819, PubMed:33468622). {ECO:0000269|PubMed:12668730, ECO:0000269|PubMed:17994011, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:33468622}.
uniprot
proteins
mass_dalton
51909
uniprot
proteins
mutagenesis
MUTAGEN 132; /note="K->A: Abolishes phosphatidylinositol phosphate binding. Abolishes endosomal location."; /evidence="ECO:0000269|PubMed:17994011
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
12668730
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17994011
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
32513819
uniprot
proteins
pubmed
33468622
uniprot
proteins
pubmed
37158588
uniprot
proteins
pubmed
9819414
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:17994011, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:33468622}; Peripheral membrane protein {ECO:0000269|PubMed:17994011}; Cytoplasmic side {ECO:0000269|PubMed:17994011}. Note=Also detected on a juxtanuclear endocytic recycling compartment (ERC). {ECO:0000269|PubMed:17994011}.
uniprot
proteins