Cr1l
entrez
12946
canonical
uniprot
Q64735
canonical
ensembl
ENSMUSG00000016481
resolver
ensp
ENSMUSP00000074902
resolver
ensp
ENSMUSP00000142069
resolver
ensp
ENSMUSP00000142309
resolver
enst
ENSMUST00000193094
resolver
enst
ENSMUST00000194111
resolver
genesymbol
Cr1l
resolver
genesymbol_syn
Crry
resolver
genesymbol_syn
Cry
resolver
uniprot
A0A0A6YXN9
resolver
uniprot
A0A0A6YY75
resolver
uniprot
E9QL18
resolver
uniprot
Q3TV30
resolver
uniprot
Q58E68
resolver
uniprot
Q61447
resolver
uniprot
Q61449
resolver
uniprot
Q8CF59
resolver
uniprot
Q8K328
resolver
uniprot_entry
A0A0A6YXN9_MOUSE
resolver
uniprot_entry
A0A0A6YY75_MOUSE
resolver
uniprot_entry
CR1L_MOUSE
resolver
uniprot_sec
E9QL18
resolver
uniprot_sec
Q3TV30
resolver
uniprot_sec
Q58E68
resolver
uniprot_sec
Q61447
resolver
uniprot_sec
Q61449
resolver
uniprot_sec
Q8CF59
resolver
uniprot_sec
Q8K328
resolver
amino_acid_sequence
MEVSSRSSEPLDPVWLLVAFGRGGVKLEVLLLFLLPFTLGELRGGLGKHGHTVHREPAVNRLCADSKRWSGLPVSAQRPFPMGHCPAPSQLPSAKPINLTDESMFPIGTYLLYECLPGYIKRQFSITCKQDSTWTSAEDKCIRKQCKTPSDPENGLVHVHTGIQFGSRINYTCNQGYRLIGSSSAVCVITDQSVDWDTEAPICEWIPCEIPPGIPNGDFFSSTREDFHYGMVVTYRCNTDARGKALFNLVGEPSLYCTSNDGEIGVWSGPPPQCIELNKCTPPPYVENAVMLSENRSLFSLRDIVEFRCHPGFIMKGASSVHCQSLNKWEPELPSCFKGVICRLPQEMSGFQKGLGMKKEYYYGENVTLECEDGYTLEGSSQSQCQSDGSWNPLLAKCVSRSISGLIVGIFIGIIVFILVIIVFIWMILKYKKRNTTDEKYKEVGIHLNYKEDSCVRLQSLLTSQENSSTTSPARNSLTQEVS
uniprot
proteins
function
FUNCTION: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion. {ECO:0000269|PubMed:10642554, ECO:0000269|PubMed:10779754, ECO:0000269|PubMed:11986227, ECO:0000269|PubMed:1730912, ECO:0000269|PubMed:7528766}.
uniprot
proteins
mass_dalton
53763
uniprot
proteins
protein_family
Receptors of complement activation (RCA) family
uniprot
proteins
pubmed
10642554
uniprot
proteins
pubmed
10779754
uniprot
proteins
pubmed
11986227
uniprot
proteins
pubmed
12767833
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
1730912
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2307848
uniprot
proteins
pubmed
2911011
uniprot
proteins
pubmed
7528766
uniprot
proteins
pubmed
7691944
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 406..426; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins