Etv4
entrez
18612
canonical
uniprot
P28322
canonical
ensembl
ENSMUSG00000017724
resolver
ensp
ENSMUSP00000017868
resolver
ensp
ENSMUSP00000102794
resolver
ensp
ENSMUSP00000129261
resolver
ensp
ENSMUSP00000309750
resolver
ensp
ENSMUSP00000309754
resolver
ensp
ENSMUSP00000309759
resolver
enst
ENSMUST00000017868
resolver
enst
ENSMUST00000107176
resolver
genesymbol
Etv4
resolver
genesymbol_syn
Pea-3
resolver
genesymbol_syn
Pea3
resolver
uniprot
A2A5C2
resolver
uniprot
A2A5C3
resolver
uniprot
A6MDC6
resolver
uniprot
Q3UMZ6
resolver
uniprot_entry
A2A5C2_MOUSE
resolver
uniprot_entry
A2A5C3_MOUSE
resolver
uniprot_entry
A6MDC6_MOUSE
resolver
uniprot_entry
ETV4_MOUSE
resolver
uniprot_sec
Q3UMZ6
resolver
amino_acid_sequence
MERRMKGGYLDQRVPYTFCSKSPGNGSLGEALMVPQGKLMDPGSLPPSDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENSFHSPTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDSPRQIAIKSPAPGAPGQSPLQPFSRAEQQQSLLRASSSSQSHPGHGYLGEHSSVFQQPVDMCHSFTSPQGGGREPLPAPYQHQLSEPCPPYPQQNFKQEYHDPLYEQAGQPASSQGGVSGHRYPGAGVVIKQERTDFAYDSDVPGCASMYLHPEGFSGPSPGDGVMGYGYEKSLRPFPDDVCIVPEKFEGDIKQEGIGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDESPAYLPELTGPAPPFGHRGGYSY
uniprot
proteins
function
FUNCTION: Transcriptional activator (PubMed:1547944). Regulates the positioning of motor neurons within the lateral medial column of the spinal cord and controls the terminal arborization of specific motor neuron axons within their target muscles (PubMed:12372283). Required for the expression of CDH8 and SEMA3E in ETV4-expressing motor neurons and for the exclusion of CDH7 expression from these neurons (PubMed:12372283). May play a role in keratinocyte differentiation (By similarity). {ECO:0000250|UniProtKB:P43268, ECO:0000269|PubMed:12372283, ECO:0000269|PubMed:1547944}.
uniprot
proteins
mass_dalton
54008
uniprot
proteins
post_translational_modification
PTM: Sumoylated; enhanced upon ERK/MAP kinase pathway activation it positively regulates the transcriptional activator capacity. Sumoylation at Lys-95 probably requires phosphorylation at Ser-100. Transiently polysumoylated and desumoylated by SENP1. Sumoylation is a prerequisite to polyubiquitination which in turn increases proteasomal-mediated degradation. Probably polyubiquitinated by RNF4 and deubiquitinated by USP2. {ECO:0000250|UniProtKB:P43268}.
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
12372283
uniprot
proteins
pubmed
1547944
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
485
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
uniprot
proteins