Nop53
entrez
68077
canonical
uniprot
Q8BK35
canonical
ensembl
ENSMUSG00000041560
resolver
ensp
ENSMUSP00000043981
resolver
enst
ENSMUST00000044158
resolver
genesymbol
Nop53
resolver
genesymbol_syn
Gltscr2
resolver
genesymbol_syn
Pict1
resolver
uniprot
Q8VD18
resolver
uniprot_entry
NOP53_MOUSE
resolver
uniprot_sec
Q8VD18
resolver
amino_acid_sequence
MAAGGNRDGEKRGSRSQADSGFLGLRPTSVDPALRRRRRGPRNKKRGWRRLAEEPLGLEVDQFLEDVRLQERTTGGLLAEAPNEKLFFVDTGFKRKEPRKKRTLVQKKSQRLQKPLRVDLALENHSKIPAPKDILAHQVPNAKKLRRKEELWEKLAKQGELPRDVRKAQARLLSPPTPKAKPGPQDIIERPFYDLWNPDNPLDTPLIGQDAFFLEQTKKKGVRRPQRLHIKPSQVPAVEVIPAGASYNPTFEDHQALLREAHEVELQREKEAEKLERQLALPTSEQAATQESVFREMCEGLLEESDGEDEHEAGRAGQPEAGDGTTEISPTGAAGPEKRMEKKTEQQRRREKAARKLRVQQAALRAARLQHQELFRLRGIKAQVARRLAELARRREQRRIRRLAEADKPRRLGRLKYQAPDIDVQLSSELSGSLRTLKPEGHILRDRFKSFQKRNMIEPRERAKFKRKYKVKLVEKRAYREIQL
uniprot
proteins
function
FUNCTION: Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription (By similarity). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:21804542). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation. Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway. May also inhibit cell proliferation and increase apoptosis through its interaction with NF2. May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation. Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex. May also regulate cellular aerobic respiration. In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI (By similarity). {ECO:0000250|UniProtKB:Q9NZM5, ECO:0000269|PubMed:21804542}.
uniprot
proteins
mass_dalton
55793
uniprot
proteins
post_translational_modification
PTM: Ubiquitin-mediated proteasomal degradation is regulated by c-JUN. It is associated with relocalization to the nucleoplasm and decreased homooligomerization. {ECO:0000250|UniProtKB:Q9NZM5}.; PTM: Phosphorylated upon DNA damage probably by ATM and DNA-PK; may regulate NOP53 degradation. {ECO:0000250|UniProtKB:Q9NZM5}.
uniprot
proteins
protein_family
NOP53 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21804542
uniprot
proteins
sequence_length
484
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:21804542}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9NZM5}. Note=In the nucleolus may be more specifically localized to the fibrillar center. Mainly nucleolar it relocalizes to the nucleoplasm under specific conditions including ribosomal stress enabling it to interact and regulate nucleoplasmic proteins like p53/TP53. Also detected in the cytosol. {ECO:0000250|UniProtKB:Q9NZM5}.
uniprot
proteins