Slc34a1
entrez
25548
canonical
uniprot
Q06496
canonical
ensembl
ENSRNOG00000015262
resolver
ensembl
ENSRNOG00055015870
resolver
ensp
ENSRNOP00000031764
resolver
ensp
ENSRNOP00055021812
resolver
enst
ENSRNOT00000033749
resolver
enst
ENSRNOT00055027010
resolver
genesymbol
Slc34a1
resolver
genesymbol_syn
Slc17a2
resolver
uniprot_entry
NPT2A_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Transport activity is significantly increased in response to dietary phosphate deprivation. {ECO:0000269|PubMed:9058191}.
uniprot
proteins
amino_acid_sequence
MMSYSERLGGPAVSPLPVRGRHMVHGAAFAYVPSPQVLHRIPGTTTYAISSLSPVALTEHSCPYGEVLECHDPLPAKLAQEEEQKPEPRLSQKLAQVGTKLLKVPLMLGFLYLFVCSLDVLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHVTGLVVASFNIRGGRDAPDLLKVITEPFTKLIIQLDKSVITSIAVGDESLRNHSLIRIWCQPETKEASTSMSRVEAIGSLANTTMEKCNHIFVDTGLPDLAVGLILLAGSLVVLCTCLILLVKMLNSLLKGQVANVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSSFQIALCHFFFNISGILLWYPLPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQAMVGVGTPFGALLAFVVLVNVLQSRSPGHLPKWLQTWDFLPRWMHSLQPLDGLITRATLCYARPEPRSPQLPPRVFLEELPPATPSPRLALPAHHNATRL
uniprot
proteins
function
FUNCTION: Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:10198426, PubMed:10370077, PubMed:10926678, PubMed:8327470, PubMed:9058191). The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (PubMed:10198426). {ECO:0000269|PubMed:10198426, ECO:0000269|PubMed:10370077, ECO:0000269|PubMed:10926678, ECO:0000269|PubMed:8327470, ECO:0000269|PubMed:9058191}.
uniprot
proteins
mass_dalton
68707
uniprot
proteins
mutagenesis
MUTAGEN 62; /note="C->S: Reduced protein expression and transport activity."; /evidence="ECO:0000269|PubMed:10926678"; MUTAGEN 70; /note="C->S: No effect on protein expression and transport activity."; /evidence="ECO:0000269|PubMed:10926678"; MUTAGEN 116; /note="C->S: No effect on protein expression and transport activity."; /evidence="ECO:0000269|PubMed:10926678"; MUTAGEN 225; /note="C->S: No effect on protein expression but reduced transport activity. Reduced protein expression and loss of transport activity; when associated with S-306 or S-334."; /evidence="ECO:0000269|PubMed:10926678"; MUTAGEN 306; /note="C->S: No effect on protein expression but reduced transport activity. Reduced protein expression and loss of transport activity; when associated with S-225 or S-520. No effect on protein expression and reduced transport activity; when associated with S-334."; /evidence="ECO:0000269|PubMed:10926678"; MUTAGEN 334; /note="C->S: No effect on protein expression but reduced transport activity. Reduced protein expression and loss of transport activity; when associated with S-225. No effect on protein expression and reduced transport activity; when associated with S-306."; /evidence="ECO:0000269|PubMed:10926678"; MUTAGEN 361; /note="C->S: No effect on protein expression and transport activity."; /evidence="ECO:0000269|PubMed:10926678"; MUTAGEN 363; /note="C->S: No effect on protein expression but reduced transport activity."; /evidence="ECO:0000269|PubMed:10926678"; MUTAGEN 474; /note="C->S: Reduced protein expression and transport activity."; /evidence="ECO:0000269|PubMed:10926678"; MUTAGEN 491; /note="C->S: No effect on protein expression and transport activity."; /evidence="ECO:0000269|PubMed:10926678"; MUTAGEN 520; /note="C->S: No effect on protein expression and transport activity. Reduced protein expression and loss of transport activity; when associated with S-306."; /evidence="ECO:0000269|PubMed:10926678"; MUTAGEN 597; /note="C->S: Reduced protein expression and transport activity."; /evidence="ECO:0000269|PubMed:10926678
uniprot
proteins
protein_family
SLC34A transporter family
uniprot
proteins
pubmed
10198426
uniprot
proteins
pubmed
10370077
uniprot
proteins
pubmed
10926678
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8327470
uniprot
proteins
pubmed
8691716
uniprot
proteins
pubmed
9058191
uniprot
proteins
sequence_length
637
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q06495}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:10370077, ECO:0000269|PubMed:8691716, ECO:0000269|PubMed:9058191}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of the proximal tubules. Internalized from the cell surface upon PTH stimulation (By similarity). {ECO:0000250|UniProtKB:Q60825, ECO:0000269|PubMed:8691716, ECO:0000269|PubMed:9058191}.
uniprot
proteins
transmembrane_region
TRANSMEM 104..125; /note="Helical; Name=M1"; /evidence="ECO:0000255"; TRANSMEM 146..163; /note="Helical; Name=M2"; /evidence="ECO:0000255"; TRANSMEM 217..236; /note="Helical; Name=M3"; /evidence="ECO:0000255"; TRANSMEM 346..368; /note="Helical; Name=M4"; /evidence="ECO:0000255"; TRANSMEM 411..434; /note="Helical; Name=M5"; /evidence="ECO:0000255"; TRANSMEM 465..485; /note="Helical; Name=M6"; /evidence="ECO:0000255"; TRANSMEM 512..532; /note="Helical; Name=M7"; /evidence="ECO:0000255"; TRANSMEM 538..559; /note="Helical; Name=M8"; /evidence="ECO:0000255
uniprot
proteins