IL23A
entrez
51561
canonical
uniprot
Q9NPF7
canonical
ensembl
ENSG00000110944
resolver
ensp
ENSP00000228534
resolver
enst
ENST00000228534
resolver
genesymbol
IL23A
resolver
genesymbol_syn
SGRF
resolver
hgnc
HGNC:15488
resolver
uniprot
Q6NZ80
resolver
uniprot
Q6NZ82
resolver
uniprot
Q9H2A5
resolver
uniprot_entry
IL23A_HUMAN
resolver
uniprot_sec
Q6NZ80
resolver
uniprot_sec
Q6NZ82
resolver
uniprot_sec
Q9H2A5
resolver
amino_acid_sequence
MLGSRAVMLLLLLPWTAQGRAVPGGSSPAWTQCQQLSQKLCTLAWSAHPLVGHMDLREEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIHQGLIFYEKLLGSDIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGAATLSP
uniprot
proteins
function
FUNCTION: Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed:11114383). Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 (PubMed:29287995, PubMed:32474165, PubMed:33606986). This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A (PubMed:12023369). In turn, participates in the early and effective intracellular bacterial clearance (PubMed:32474165). Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells (PubMed:17676044). {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:16424222, ECO:0000269|PubMed:17676044, ECO:0000269|PubMed:29287995, ECO:0000269|PubMed:32474165, ECO:0000269|PubMed:33606986}.
uniprot
proteins
mass_dalton
20730
uniprot
proteins
protein_family
IL-6 superfamily
uniprot
proteins
pubmed
11114383
uniprot
proteins
pubmed
12023369
uniprot
proteins
pubmed
12421946
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15114670
uniprot
proteins
pubmed
15486065
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15731058
uniprot
proteins
pubmed
16342235
uniprot
proteins
pubmed
16424222
uniprot
proteins
pubmed
16688182
uniprot
proteins
pubmed
16751425
uniprot
proteins
pubmed
17676044
uniprot
proteins
pubmed
18680750
uniprot
proteins
pubmed
29287995
uniprot
proteins
pubmed
32474165
uniprot
proteins
pubmed
32479512
uniprot
proteins
pubmed
33606986
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11114383}. Note=Secreted upon association with IL12B.
uniprot
proteins