Cpt1a
entrez
25757
canonical
uniprot
P32198
canonical
ensembl
ENSRNOG00000014254
resolver
ensembl
ENSRNOG00055020936
resolver
ensembl
ENSRNOG00065030877
resolver
ensp
ENSRNOP00000019652
resolver
ensp
ENSRNOP00055029003
resolver
ensp
ENSRNOP00065043724
resolver
enst
ENSRNOT00000019652
resolver
enst
ENSRNOT00055035746
resolver
enst
ENSRNOT00065053227
resolver
genesymbol
Cpt1a
resolver
genesymbol_syn
Cpt-1
resolver
genesymbol_syn
Cpt1
resolver
uniprot
P97780
resolver
uniprot
Q6IMZ4
resolver
uniprot_entry
CPT1A_RAT
resolver
uniprot_sec
P97780
resolver
uniprot_sec
Q6IMZ4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by malonyl-CoA. {ECO:0000269|PubMed:16908527, ECO:0000269|PubMed:21990363}.
uniprot
proteins
amino_acid_sequence
MAEAHQAVAFQFTVTPDGIDLRLSHEALKQICLSGLHSWKKKFIRFKNGIITGVFPANPSSWLIVVVGVISSMHAKVDPSLGMIAKISRTLDTTGRMSSQTKNIVSGVLFGTGLWVAVIMTMRYSLKVLLSYHGWMFAEHGKMSRSTKIWMAMVKVLSGRKPMLYSFQTSLPRLPVPAVKDTVSRYLESVRPLMKEEDFQRMTALAQDFAVNLGPKLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMEMLYITPTHIQAARAGNTIHAILLYRRTLDREELKPIRLLGSTIPLCSAQWERLFNTSRIPGEETDTIQHIKDSRHIVVYHRGRYFKVWLYHDGRLLRPRELEQQMQQILDDPSEPQPGEAKLAALTAADRVPWAKCRQTYFARGKNKQSLDAVEKAAFFVTLDESEQGYREEDPEASIDSYAKSLLHGRCFDRWFDKSITFVVFKNSKIGINAEHSWADAPVVGHLWEYVMATDVFQLGYSEDGHCKGDTNPNIPKPTRLQWDIPGECQEVIDASLSSASLLANDVDLHSFPFDSFGKGLIKKCRTSPDAFIQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTMESCNFVQAMMDPKSTAEQRLKLFKIACEKHQHLYRLAMTGAGIDRHLFCLYVVSKYLAVDSPFLKEVLSEPWRLSTSQTPQQQVELFDFEKNPDYVSCGGGFGPVADDGYGVSYIIVGENFIHFHISSKFSSPETDSHRFGKHLRQAMMDIITLFGLTINSKK
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.21
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:16908527, PubMed:21990363, PubMed:24222496). Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (By similarity). Plays an important role in hepatic triglyceride metabolism (PubMed:18349115). Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression (By similarity). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (By similarity). {ECO:0000250|UniProtKB:P50416, ECO:0000269|PubMed:16908527, ECO:0000269|PubMed:18349115, ECO:0000269|PubMed:21990363, ECO:0000269|PubMed:24222496}.
uniprot
proteins
mass_dalton
88125
uniprot
proteins
mutagenesis
MUTAGEN 3; /note="E->R: Decreases susceptibility to inhibition by malonyl-CoA."; /evidence="ECO:0000269|PubMed:21990363"; MUTAGEN 9; /note="A->G: Increases susceptibility to inhibition by malonyl-CoA."; /evidence="ECO:0000269|PubMed:21990363"; MUTAGEN 18; /note="G->A: Increases susceptibility to inhibition by malonyl-CoA."; /evidence="ECO:0000269|PubMed:21990363"; MUTAGEN 381; /note="A->D: Reduces activity by 86%. No effect on inhibition by malonyl-coenzyme A."; /evidence="ECO:0000269|PubMed:11553629"; MUTAGEN 473; /note="H->A: Loss of activity."; /evidence="ECO:0000269|PubMed:11553629"; MUTAGEN 477; /note="D->A: Reduces activity by 98%."; /evidence="ECO:0000269|PubMed:14711372"; MUTAGEN 560; /note="K->A: Reduces activity by 50%."; /evidence="ECO:0000269|PubMed:14711372"; MUTAGEN 567; /note="D->A: Reduces activity by 97%."; MUTAGEN 590; /note="E->D: Reduces activity by over 60%."; /evidence="ECO:0000269|PubMed:14711372"; MUTAGEN 593; /note="M->A,E,S: Almost abolishes inhibition by malonyl-coenzyme A."; /evidence="ECO:0000269|PubMed:12499375"; MUTAGEN 608; /note="C->A: Slightly lowers inhibition by malonyl-coenzyme A."; /evidence="ECO:0000269|PubMed:12499375"; MUTAGEN 685; /note="S->A: Reduces activity by 50%."; /evidence="ECO:0000269|PubMed:14711372"; MUTAGEN 686; /note="T->A: Loss of activity."; /evidence="ECO:0000269|PubMed:14711372"; MUTAGEN 687; /note="S->A: Loss of activity."; /evidence="ECO:0000269|PubMed:14711372
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
uniprot
proteins
protein_family
Carnitine/choline acetyltransferase family
uniprot
proteins
pubmed
11553629
uniprot
proteins
pubmed
12499375
uniprot
proteins
pubmed
14711372
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16908527
uniprot
proteins
pubmed
17478130
uniprot
proteins
pubmed
18192268
uniprot
proteins
pubmed
18349115
uniprot
proteins
pubmed
19136561
uniprot
proteins
pubmed
21622568
uniprot
proteins
pubmed
21990363
uniprot
proteins
pubmed
24222496
uniprot
proteins
pubmed
8348957
uniprot
proteins
pubmed
8449947
uniprot
proteins
pubmed
8449948
uniprot
proteins
pubmed
8636126
uniprot
proteins
pubmed
9136891
uniprot
proteins
pubmed
9169604
uniprot
proteins
sequence_length
773
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:16908527, ECO:0000269|PubMed:18192268, ECO:0000269|PubMed:19136561, ECO:0000269|PubMed:21622568}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..122; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins