Nicol1
entrez
381633
canonical
uniprot
Q3UR78
canonical
ensembl
ENSMUSG00000070858
resolver
ensp
ENSMUSP00000092467
resolver
ensp
ENSMUSP00000110024
resolver
ensp
ENSMUSP00000110025
resolver
genesymbol
Nicol1
resolver
genesymbol_syn
Gm1673
resolver
uniprot
B9EJP7
resolver
uniprot
Q3V2U0
resolver
uniprot_entry
NICOL_MOUSE
resolver
uniprot_sec
B9EJP7
resolver
uniprot_sec
Q3V2U0
resolver
amino_acid_sequence
MAPALRSLLSPRTLLLLLLSLALLGARAEPATGSAVPAQSRPCVDCHAFEFMQRALQDLRKTAYSLDARTETLLLQAERRALCACWPAGR
uniprot
proteins
function
FUNCTION: mRNA-binding protein which interacts with a range of target mRNAs including SERPINE1, ACTA2, CCN2 and COL4A1 and may promote extracellular matrix production (PubMed:38625739). Binds to the 3'-UTR of SERPINE1 mRNA and stabilizes the mRNA, possibly by competing for binding with SERBP1 and preventing SERBP1-mediated mRNA degradation (PubMed:38625739). Also binds to the 3'-UTR of ACTA2 (PubMed:38625739). Testis-derived lumicrine factor that triggers epididymal differentiation and sperm maturation (PubMed:37095084). {ECO:0000269|PubMed:37095084, ECO:0000269|PubMed:38625739}.
uniprot
proteins
mass_dalton
9806
uniprot
proteins
protein_family
NICOL family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21287218
uniprot
proteins
pubmed
37095084
uniprot
proteins
pubmed
38625739
uniprot
proteins
sequence_length
90
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:37095084, ECO:0000269|PubMed:38625739}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:38625739}. Note=Detected in the perinuclear region of fibroblasts. {ECO:0000269|PubMed:38625739}.
uniprot
proteins