Panx2
entrez
406218
canonical
uniprot
Q6IMP4
canonical
ensembl
ENSMUSG00000058441
resolver
ensp
ENSMUSP00000124354
resolver
genesymbol
Panx2
resolver
uniprot
B1PL20
resolver
uniprot
Q4JGM2
resolver
uniprot_entry
PANX2_MOUSE
resolver
uniprot_sec
B1PL20
resolver
uniprot_sec
Q4JGM2
resolver
amino_acid_sequence
MHHLLEQSADMATALLAGEKLRELILPGSQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSVVPISYLCTYYATQKQNEFTCALGASPDGPVGSAGPTVRVSCKLPSVQLQRIIAGVDIVLLCFMNLIILVNLIHLFIFRKSNFIFDKLNKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDTTPTVRDSGIQTVDPSINPAEPDGSAEPPVVKRPRKKMKWIPTSNPLPQPFKEQLAIMRVENSKTEKPKPVRRKTATDTLIAPLLDAGARAAHHYKGSGGDSGPSSAPPAASEKKHTRHFSLDVHPYILGTKKAKTEAVPPALPASRSQEGGFLSQTEECGLGLAAAPTKDAPLPEKEIPYPTEPALPGLPSGGSFHVCSPPAAPAAASLSPGSLGKADPLTILSRNATHPLLHISTLYEAREEEEGGPCAPSDMGDLLSIPPPQQILIATFEEPRTVVSTVEF
uniprot
proteins
function
FUNCTION: Ion channel with a slight anion preference. Also able to release ATP (By similarity). Plays a role in regulating neurogenesis and apoptosis in keratinocytes (PubMed:20529862, PubMed:34985913). {ECO:0000250|UniProtKB:Q96RD6, ECO:0000269|PubMed:20529862, ECO:0000269|PubMed:34985913}.
uniprot
proteins
mass_dalton
74614
uniprot
proteins
mutagenesis
MUTAGEN 416; /note="D->A: Not cleaved by caspases. No effect on function during apoptosis."; /evidence="ECO:0000269|PubMed:34985913
uniprot
proteins
post_translational_modification
PTM: S-palmitoylated in neural stem and progenitor cells. {ECO:0000269|PubMed:20529862}.; PTM: Cleaved by CASP3 and CASP7 during apoptosis. Cleavage has no effect on it function. {ECO:0000269|PubMed:34985913}.
uniprot
proteins
protein_family
Pannexin family
uniprot
proteins
pubmed
15028292
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20529862
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34985913
uniprot
proteins
sequence_length
677
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20529862}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Golgi apparatus membrane {ECO:0000269|PubMed:20529862}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20529862}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Note=Localizes to Golgi apparatus and endoplasmic reticulum in multipotential neural stem and progenitor cells and to plasma membrane in terminally differentiated neurons. {ECO:0000269|PubMed:20529862}.
uniprot
proteins
transmembrane_region
TRANSMEM 54..74; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"; TRANSMEM 126..146; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"; TRANSMEM 231..251; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"; TRANSMEM 296..316; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351
uniprot
proteins