QSOX2
entrez
169714
canonical
uniprot
Q6ZRP7
canonical
ensembl
ENSG00000165661
resolver
ensp
ENSP00000351536
resolver
enst
ENST00000358701
resolver
genesymbol
QSOX2
resolver
genesymbol_syn
QSCN6L1
resolver
genesymbol_syn
SOXN
resolver
hgnc
HGNC:30249
resolver
uniprot
A2CEE0
resolver
uniprot
A6NLB0
resolver
uniprot
Q5TB37
resolver
uniprot
Q7Z7B6
resolver
uniprot
Q86VV7
resolver
uniprot
Q8N3G2
resolver
uniprot_entry
QSOX2_HUMAN
resolver
uniprot_sec
A2CEE0
resolver
uniprot_sec
A6NLB0
resolver
uniprot_sec
Q5TB37
resolver
uniprot_sec
Q7Z7B6
resolver
uniprot_sec
Q86VV7
resolver
uniprot_sec
Q8N3G2
resolver
amino_acid_sequence
MAAAGAAVARSPGIGAGPALRARRSPPPRAARLPRLLVLLAAAAVGPGAGGAARLYRAGEDAVWVLDSGSVRGATANSSAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDIHFYPTFRYFKAFTKEFTTGENFKGPDRELRTVRQTMIDFLQNHTEGSRPPACPRLDPIQPSDVLSLLDNRGSHYVAIVFESNSSYLGREVILDLIPYESIVVTRALDGDKAFLEKLGVSSVPSCYLIYPNGSHGLINVVKPLRAFFSSYLKSLPDVRKKSLPLPEKPHKEENSEIVVWREFDKSKLYTVDLESGLHYLLRVELAAHKSLAGAELKTLKDFVTVLAKLFPGRPPVKKLLEMLQEWLASLPLDRIPYNAVLDLVNNKMRISGIFLTNHIKWVGCQGSRSELRGYPCSLWKLFHTLTVEASTHPDALVGTGFEDDPQAVLQTMRRYVHTFFGCKECGEHFEEMAKESMDSVKTPDQAILWLWKKHNMVNGRLAGHLSEDPRFPKLQWPTPDLCPACHEEIKGLASWDEGHVLTFLKQHYGRDNLLDTYSADQGDSSEGGTLARGEEEEKRLTPPEVSHGDRDTQSVRPPGALGPRPALPESLHHSLDGKLQSLDGPGAHKEVGGAAPFLGVDFSSLDMSLCVVLYVASSLFLMVMYFFFRVRSRRWKVKHHHPAV
uniprot
proteins
ec_number
1.8.3.2
uniprot
proteins
function
FUNCTION: Sulfhydryl oxidase that catalyzes the oxidation of protein thiol groups to form disulfide bonds, with the reduction of oxygen to hydrogen peroxide (By similarity). May contribute to disulfide bond formation in secreted proteins (By similarity). May play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis (PubMed:14633699). Required for normal ovarian function (By similarity). {ECO:0000250|UniProtKB:O00391, ECO:0000250|UniProtKB:Q3TMX7, ECO:0000269|PubMed:14633699}.
uniprot
proteins
mass_dalton
77529
uniprot
proteins
protein_family
Quiescin-sulfhydryl oxidase (QSOX) family
uniprot
proteins
pubmed
14633699
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
698
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:14633699}; Single-pass membrane protein {ECO:0000269|PubMed:14633699}. Secreted {ECO:0000269|PubMed:14633699}. Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane.
uniprot
proteins
transmembrane_region
TRANSMEM 662..682; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins