Chac1
entrez
69065
canonical
uniprot
Q8R3J5
canonical
ensembl
ENSMUSG00000027313
resolver
ensp
ENSMUSP00000028780
resolver
enst
ENSMUST00000028780
resolver
genesymbol
Chac1
resolver
genesymbol_syn
Botch
resolver
uniprot
A2AV63
resolver
uniprot
Q9D944
resolver
uniprot_entry
CHAC1_MOUSE
resolver
uniprot_sec
A2AV63
resolver
uniprot_sec
Q9D944
resolver
amino_acid_sequence
MKQESASQSTPPPSLSPAPSSAQPSWGDGDPQALWIFGYGSLVWKPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDREGCTWGVAYQVRGEQVNEALKYLNVREAVLGGYDTKEVTFYPQDTPDQPLTALAYVATPQNPGYLGPAPEEVIATQILACRGFSGHNLEYLLRLADFMQLCGPQAQDEHLEAIVDAVGTLLPCSYLPEQPLALT
uniprot
proteins
ec_number
4.3.2.7
uniprot
proteins
function
FUNCTION: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (By similarity). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366). {ECO:0000250|UniProtKB:Q9BUX1, ECO:0000269|PubMed:22445366, ECO:0000269|PubMed:23070364}.
uniprot
proteins
mass_dalton
24547
uniprot
proteins
mutagenesis
MUTAGEN 116; /note="E->Q: Loss of catalytic activity against glutathione."; /evidence="ECO:0000269|PubMed:23070364
uniprot
proteins
protein_family
ChaC subfamily
uniprot
proteins
protein_family
Gamma-glutamylcyclotransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22445366
uniprot
proteins
pubmed
23070364
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BUX1}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:22445366}.
uniprot
proteins