INHBA
entrez
3624
canonical
uniprot
P08476
canonical
ensembl
ENSG00000122641
resolver
ensp
ENSP00000242208
resolver
ensp
ENSP00000397197
resolver
ensp
ENSP00000490646
resolver
ensp
ENSP00000537882
resolver
ensp
ENSP00000586786
resolver
ensp
ENSP00000617935
resolver
ensp
ENSP00000617937
resolver
ensp
ENSP00000617938
resolver
enst
ENST00000242208
resolver
enst
ENST00000442711
resolver
enst
ENST00000638023
resolver
enst
ENST00000867823
resolver
enst
ENST00000916727
resolver
enst
ENST00000947876
resolver
enst
ENST00000947878
resolver
enst
ENST00000947879
resolver
genesymbol
INHBA
resolver
hgnc
HGNC:6066
resolver
uniprot
A4D1W7
resolver
uniprot
Q14599
resolver
uniprot_entry
A4D1W7_HUMAN
resolver
uniprot_entry
INHBA_HUMAN
resolver
uniprot_sec
Q14599
resolver
amino_acid_sequence
MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
uniprot
proteins
function
FUNCTION: Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. {ECO:0000269|PubMed:11279126}.; FUNCTION: Activin A is a homodimer of INHBA that plays a role in several essential biological processes including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis (PubMed:3194407, PubMed:16440334). Signals through type I (such as ACVR1B or ACVR1C) and type II receptors (such as ACVR2A, ACVR2B or BMPR2) which, upon ligand binding, phosphorylate SMAD2 and SMAD3 intracellular signaling mediators that form a complex with SMAD4, translocate to the nucleus and modulate gene expression (PubMed:10652306, PubMed:24018044). Can also activate alternative non-canonical intracellular signaling pathways including the p38 MAPK, extracellular signal-regulated kinases 1/2 (ERK1/2) and c-Jun N-terminal kinases (JNKs) to modulate cell migration and differentiation (PubMed:16440334). Alternatively, promotes osteoblastic differentiation via ACVRL1-SMAD1/5/9 pathway (PubMed:34948289). In addition, can engage the type I receptor ACVR1 to form an ACVR1-activin A-type II receptor non-signaling complex (NSC) that renders receptors unavailable for engagement with BMPs, hence resulting in an apparent inhibition of ACVR1-mediated BMP signaling (PubMed:26333933). {ECO:0000269|PubMed:10652306, ECO:0000269|PubMed:16440334, ECO:0000269|PubMed:24018044, ECO:0000269|PubMed:26333933, ECO:0000269|PubMed:3194407, ECO:0000269|PubMed:34948289}.; FUNCTION: Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor. {ECO:0000269|PubMed:10746731}.
uniprot
proteins
mass_dalton
47442
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
10652306
uniprot
proteins
pubmed
10746731
uniprot
proteins
pubmed
11279126
uniprot
proteins
pubmed
12660162
uniprot
proteins
pubmed
12697670
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16440334
uniprot
proteins
pubmed
1777673
uniprot
proteins
pubmed
18768470
uniprot
proteins
pubmed
24018044
uniprot
proteins
pubmed
24302632
uniprot
proteins
pubmed
26333933
uniprot
proteins
pubmed
3194407
uniprot
proteins
pubmed
3267209
uniprot
proteins
pubmed
34948289
uniprot
proteins
pubmed
3754442
uniprot
proteins
pubmed
3758355
uniprot
proteins
sequence_length
426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11279126}.
uniprot
proteins