Pou3f2
entrez
18992
canonical
uniprot
P31360
canonical
ensembl
ENSMUSG00000095139
resolver
ensp
ENSMUSP00000136147
resolver
enst
ENSMUST00000178174
resolver
genesymbol
Pou3f2
resolver
genesymbol_syn
Brn-2
resolver
genesymbol_syn
Brn2
resolver
genesymbol_syn
Otf7
resolver
uniprot
A2AJY1
resolver
uniprot_entry
PO3F2_MOUSE
resolver
uniprot_sec
A2AJY1
resolver
amino_acid_sequence
MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ
uniprot
proteins
function
FUNCTION: Transcription factor that plays a key role in neuronal differentiation (PubMed:24243019). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (PubMed:18403418, PubMed:18505825). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (PubMed:24243019). {ECO:0000250|UniProtKB:P56222, ECO:0000269|PubMed:18403418, ECO:0000269|PubMed:18505825, ECO:0000269|PubMed:20107439, ECO:0000269|PubMed:24243019, ECO:0000269|PubMed:27281220}.
uniprot
proteins
mass_dalton
47149
uniprot
proteins
protein_family
Class-3 subfamily
uniprot
proteins
protein_family
POU transcription factor family
uniprot
proteins
pubmed
1565620
uniprot
proteins
pubmed
18403418
uniprot
proteins
pubmed
18505825
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20107439
uniprot
proteins
pubmed
24243019
uniprot
proteins
pubmed
24643061
uniprot
proteins
pubmed
27281220
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins