Thumpd2
entrez
72167
canonical
uniprot
Q9CZB3
canonical
ensembl
ENSMUSG00000024246
resolver
ensp
ENSMUSP00000025093
resolver
ensp
ENSMUSP00000225946
resolver
ensp
ENSMUSP00000225948
resolver
ensp
ENSMUSP00000225950
resolver
ensp
ENSMUSP00000225955
resolver
enst
ENSMUST00000025093
resolver
genesymbol
Thumpd2
resolver
uniprot_entry
THUM2_MOUSE
resolver
amino_acid_sequence
MAVAQADPGSDPAGGARFFCTAGRGLEPFLMREVRARLEATQVEYISGKVFFTTCSDLPSMKKLKSAERLFVLIKKQLPIAVSSLHKGKILNEMQRFVNDDPGSWLEAISLWKKLLEHDPKREKVSQRDANPLKRKAGENETIIAKKLKVEEKQEVAKDHGESQEDKLLQGSPEQGEAVTRTELQDHRLNSTTEKAADAQDQEDLTFRVSCRCTGNVRKVITGQEAGRVIGLALMRQFGWKADLRNPNIEIFMHLSDAYSVVGIPLLRMPLASRTYIQTAGLRSTIAWAMASIAEIKAGALVLDPMCGLGTILVEAAEEWPDVFYMGADMSDAQLLGACDNLKAAGLTDRIELLKSSVTDLPLPSQSTDVIISDIPFGKKFKLGKDIKSILQEMERVLRVGGAMVLLLSEDHHRHLTDCGGSSIPLTSKGHIAEPEMKTLSNPDRTGAPDTASPSQRASSVQCLGRMRPCGSLVPVESFKVSLGKTDAFICKYKKAQASGLSSAECHEPGAHTEMAAMQESPSLQDSL
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Catalytic subunit of the THUMPD2-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotides, most probably at position 72 (m2G72), in the U6snRNA of the major spliceosome. This modification in the U6 snRNA affects the constitutive splicing efficiency of introns that have suboptimal splice sites and can impact final mRNA levels. {ECO:0000250|UniProtKB:Q9BTF0}.
uniprot
proteins
mass_dalton
57669
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
528
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BTF0}.
uniprot
proteins