SENP8
entrez
123228
canonical
uniprot
Q96LD8
canonical
ensembl
ENSG00000166192
resolver
ensp
ENSP00000340505
resolver
ensp
ENSP00000446057
resolver
ensp
ENSP00000589495
resolver
enst
ENST00000340912
resolver
enst
ENST00000542035
resolver
enst
ENST00000919436
resolver
genesymbol
SENP8
resolver
genesymbol_syn
DEN1
resolver
genesymbol_syn
NEDP1
resolver
genesymbol_syn
PRSC2
resolver
hgnc
HGNC:22992
resolver
uniprot
A8K8D3
resolver
uniprot
Q96QA4
resolver
uniprot_entry
A8K8D3_HUMAN
resolver
uniprot_entry
SENP8_HUMAN
resolver
uniprot_sec
Q96QA4
resolver
amino_acid_sequence
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
function
FUNCTION: Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. {ECO:0000269|PubMed:12730221, ECO:0000269|PubMed:12759362, ECO:0000269|PubMed:12759363, ECO:0000269|PubMed:15242646, ECO:0000269|PubMed:15775960}.
uniprot
proteins
mass_dalton
24107
uniprot
proteins
mutagenesis
MUTAGEN 10; /note="D->A: No effect on activity."; /evidence="ECO:0000269|PubMed:15775960"; MUTAGEN 26; /note="W->A: Strongly reduces activity."; /evidence="ECO:0000269|PubMed:15775960"; MUTAGEN 29; /note="D->A,N: Abolishes activity."; /evidence="ECO:0000269|PubMed:15775960"; MUTAGEN 58; /note="V->A: No effect on activity."; /evidence="ECO:0000269|PubMed:15775960"; MUTAGEN 74; /note="F->A: No effect on activity."; /evidence="ECO:0000269|PubMed:15775960"; MUTAGEN 77; /note="P->A: No effect on activity."; /evidence="ECO:0000269|PubMed:15775960"; MUTAGEN 91; /note="N->A: Abolishes activity."; /evidence="ECO:0000269|PubMed:15775960"; MUTAGEN 102; /note="H->N: Abolishes activity."; /evidence="ECO:0000269|PubMed:15775960"; MUTAGEN 103; /note="W->A,H: Strongly reduces activity."; /evidence="ECO:0000269|PubMed:15775960"; MUTAGEN 119; /note="D->A,N: Abolishes activity."; /evidence="ECO:0000269|PubMed:15775960"; MUTAGEN 157; /note="Q->A: No effect on activity."; /evidence="ECO:0000269|PubMed:15775960"; MUTAGEN 163; /note="C->A: Abolishes activity."; /evidence="ECO:0000269|PubMed:12730221, ECO:0000269|PubMed:15242646, ECO:0000269|PubMed:15775960
uniprot
proteins
protein_family
Peptidase C48 family
uniprot
proteins
pubmed
12730221
uniprot
proteins
pubmed
12759362
uniprot
proteins
pubmed
12759363
uniprot
proteins
pubmed
15242646
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15567417
uniprot
proteins
pubmed
15775960
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
22223895
uniprot
proteins
sequence_length
212
uniprot
proteins