Dpy19l1
entrez
244745
canonical
uniprot
A6X919
canonical
ensembl
ENSMUSG00000043067
resolver
ensp
ENSMUSP00000119986
resolver
ensp
ENSMUSP00000129575
resolver
genesymbol
Dpy19l1
resolver
uniprot
Q3UP31
resolver
uniprot
Q8CD79
resolver
uniprot_entry
D19L1_MOUSE
resolver
uniprot_sec
Q3UP31
resolver
uniprot_sec
Q8CD79
resolver
amino_acid_sequence
MVLQARSKHRDAAPRPPRSARSSPPPLSGASEVDAGELGSERTPPSPGRRGAAGRKGPRAGTAAPAPDGLAGRLAAGLHWALGLRRGRGRTWSTLLLASFAALLHWSHITHLFENDRHFSHLSTLEREMAFRTEMGLYYSYFKTIVEAPSFLNGVWMIMNDKLTEYPLVINTLKRFNLYPEVILASWYRIYTKIMDLIGIQTKICWTVTRGEGLSPIESCEGLGDPACFYVAVIFMLNGLMMALFFIYGTYLSGSRLGGVVTVLCFFFNHGECTRVMWTPPLRESFSYPFLVLQMLLVTHILRAPELCRGSLIALCISNVLFMLPWQFAQFVLLTQIASLFAVYVVGYIDTHKLQKIIYMHMISLVLCFVLMFGNSMLLTSYYASSLVIIWGMLAMKPQFLRMNVSELSLWVIQGCGWLFGTVILKSVTSRIFGIADDAHIGNLLTSKFFSYKDFDTLLYTCAAEFDFMEKETPLRYTKTLLLPVVLVTVAAIVRKIFNDMRGVVAKQRTHTRKQQFEHGELVYHALQLLAYTALGVLIMRLKLFLTPHMCVMASLICSRQLFGWLFGKVHPGAVVFAILAAMSIQGSANLQTQWNIVGEFSNLPQEELIEWIRYSTKPDAVFAGAMPTMASVKLSALRPVVNHPHYEDAGLRARTKIVYSMYSRKAPEDVKKELMKLKVNYYILEESWCIRRSKPGCSMPEIWDVEDPDNAGKTPLCNILVKDSKPHFTTVFQNSVYKVLEVLRQ
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
function
FUNCTION: C-mannosyltransferase that mediates the C-mannosylation tryptophan residues on target proteins. The reaction occurs on the luminal side of the endoplasmic reticulum and involves the transfer of a mannose unit from a dolichylphosphate mannose (Dol-P-Man) donor to an acceptor protein containing a WxxW consensus sequence (PubMed:28202721). C-mannosylates the first two tryptophans in the WxxWxxWxxC sequence motif in thrombospondin (TSP) type-1 repeats of UNC5A (PubMed:28202721). Regulates neurite extension during development (PubMed:27959946, PubMed:28202721). {ECO:0000269|PubMed:27959946, ECO:0000269|PubMed:28202721}.
uniprot
proteins
mass_dalton
84187
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:28202721}.
uniprot
proteins
protein_family
Dpy-19 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22028030
uniprot
proteins
pubmed
27959946
uniprot
proteins
pubmed
28202721
uniprot
proteins
sequence_length
746
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27959946}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 137..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 227..247; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 257..279; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 307..325; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 331..350; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 357..374; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 380..396; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 405..425; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 481..501; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 520..540; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 562..582; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins