CCNH
entrez
902
canonical
uniprot
P51946
canonical
ensembl
ENSG00000134480
resolver
ensp
ENSP00000256897
resolver
ensp
ENSP00000426075
resolver
ensp
ENSP00000494460
resolver
ensp
ENSP00000518855
resolver
ensp
ENSP00000558865
resolver
ensp
ENSP00000558866
resolver
ensp
ENSP00000632291
resolver
ensp
ENSP00000632292
resolver
ensp
ENSP00000672834
resolver
ensp
ENSP00000672840
resolver
ensp
ENSP00000785601
resolver
enst
ENST00000256897
resolver
enst
ENST00000645953
resolver
enst
ENST00000713562
resolver
enst
ENST00000888806
resolver
enst
ENST00000888807
resolver
enst
ENST00000962232
resolver
enst
ENST00000962233
resolver
genesymbol
CCNH
resolver
hgnc
HGNC:1594
resolver
uniprot
A0A2R8YEM2
resolver
uniprot
Q53X72
resolver
uniprot
Q8TBL9
resolver
uniprot_entry
A0A2R8YEM2_HUMAN
resolver
uniprot_entry
CCNH_HUMAN
resolver
uniprot_sec
Q53X72
resolver
uniprot_sec
Q8TBL9
resolver
amino_acid_sequence
MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL
uniprot
proteins
function
FUNCTION: Component of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalyzing the activating threonine phosphorylation of CDKs (PubMed:41100585). Binds and activates cyclin-dependent protein kinase CDK7, the catalytic subunit of CAK (PubMed:41100585). CAK activates major mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, and plays a key role in regulating cell cycle progression (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts (PubMed:7533895, PubMed:10024882). Involved in cell cycle control and in RNA transcription by RNA polymerase II (PubMed:7533895, PubMed:10024882). Its expression and activity are constant throughout the cell cycle. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:7533895}.
uniprot
proteins
mass_dalton
37643
uniprot
proteins
mutagenesis
MUTAGEN 5; /note="S->A: No effect on the transcriptional activity of the reconstituted TFIIH complex."; /evidence="ECO:0000269|PubMed:10993082"; MUTAGEN 304; /note="S->A: No effect on the transcriptional activity of the reconstituted TFIIH complex."; /evidence="ECO:0000269|PubMed:10993082
uniprot
proteins
protein_family
Cyclin C subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
10024882
uniprot
proteins
pubmed
10993082
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
41100585
uniprot
proteins
pubmed
7533895
uniprot
proteins
pubmed
8069918
uniprot
proteins
pubmed
8078587
uniprot
proteins
pubmed
8836101
uniprot
proteins
pubmed
9118957
uniprot
proteins
pubmed
9852112
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins