Arl2
entrez
56327
canonical
uniprot
Q9D0J4
canonical
ensembl
ENSMUSG00000024944
resolver
ensp
ENSMUSP00000025893
resolver
enst
ENSMUST00000025893
resolver
genesymbol
Arl2
resolver
uniprot
Q9WUM1
resolver
uniprot_entry
ARL2_MOUSE
resolver
uniprot_sec
Q9WUM1
resolver
amino_acid_sequence
MGLLTILKKMKQKERELRLLMLGLDNAGKTTILKKFNGEDVDTISPTLGFNIKTLEHRGFKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERLAGATLLIFANKQDLPGALSCNAIQEALELDSIRSHHWRIQGCSAVTGEDLLPGIDWLLDDISSRVFTAD
uniprot
proteins
function
FUNCTION: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.
uniprot
proteins
mass_dalton
20864
uniprot
proteins
mutagenesis
MUTAGEN 30; /note="T->L: Reduces affinity to GTP and GDP. Inhibits interaction with PDE6D."; /evidence="ECO:0000269|PubMed:15979089"; MUTAGEN 70; /note="Q->L: Does not reduce affinity fo GTP and GDP. Enhances interaction with PDE6D."; /evidence="ECO:0000269|PubMed:15979089
uniprot
proteins
post_translational_modification
PTM: Not N-myristoylated.
uniprot
proteins
protein_family
Arf family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11809823
uniprot
proteins
pubmed
11980706
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15979089
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules (By similarity). The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria. {ECO:0000250}.
uniprot
proteins