PBLD
entrez
64081
canonical
uniprot
P30039
canonical
ensembl
ENSG00000108187
resolver
ensp
ENSP00000308466
resolver
ensp
ENSP00000351619
resolver
ensp
ENSP00000663302
resolver
ensp
ENSP00000663303
resolver
ensp
ENSP00000663304
resolver
ensp
ENSP00000663308
resolver
genesymbol
HEL-S-306
resolver
genesymbol
PBLD
resolver
genesymbol_syn
MAWBP
resolver
hgnc
HGNC:23301
resolver
uniprot
A0A024QZK5
resolver
uniprot
A8MZJ3
resolver
uniprot
C9JIM0
resolver
uniprot
Q9HCC2
resolver
uniprot_entry
A0A024QZK5_HUMAN
resolver
uniprot_entry
PBLD_HUMAN
resolver
uniprot_sec
A8MZJ3
resolver
uniprot_sec
C9JIM0
resolver
uniprot_sec
Q9HCC2
resolver
amino_acid_sequence
MKLPIFIADAFTARAFRGNPAAVCLLENELDEDMHQKIAREMNLSETAFIRKLHPTDNFAQSSCFGLRWFTPASEVPLCGHATLASAAVLFHKIKNMNSTLTFVTLSGELRARRAEDGIVLDLPLYPAHPQDFHEVEDLIKTAIGNTLVQDICYSPDTQKLLVRLSDVYNRSFLENLKVNTENLLQVENTGKVKGLILTLKGEPGGQTQAFDFYSRYFAPWVGVAEDPVTGSAHAVLSSYWSQHLGKKEMHAFQCSHRGGELGISLRPDGRVDIRGGAAVVLEGTLTA
uniprot
proteins
function
FUNCTION: Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication by enhancing type I interferon (IFN-I) response (PubMed:39362857, PubMed:39589880, PubMed:39779683). PBLD enhances IFN-I signaling via multiple pathways (PubMed:39362857, PubMed:39589880, PubMed:39779683). Promotes IRF3-mediated IFN-I production and apoptosis, thereby inhibiting viral replication (PubMed:39362857). Up-regulates IFN-I response by activating the NF-kappaB signaling pathway, potentially through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection (PubMed:39779683). Additionally, promotes the p53-USP4-MAVS signaling axis by stabilizing MAVS through USP4-mediated deubiquitination, thereby enhancing the IFN-I response against RNA virus infection (PubMed:39589880). Acts as a tumor suppressor, regulating development of various cancers (PubMed:23687415, PubMed:26594798). {ECO:0000269|PubMed:23687415, ECO:0000269|PubMed:26594798, ECO:0000269|PubMed:39362857, ECO:0000269|PubMed:39589880, ECO:0000269|PubMed:39779683}.
uniprot
proteins
mass_dalton
31785
uniprot
proteins
protein_family
PhzF family
uniprot
proteins
pubmed
11355021
uniprot
proteins
pubmed
1286669
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15806103
uniprot
proteins
pubmed
22068589
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23687415
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26594798
uniprot
proteins
pubmed
39362857
uniprot
proteins
pubmed
39589880
uniprot
proteins
pubmed
39779683
uniprot
proteins
sequence_length
288
uniprot
proteins