Fkbp4
entrez
14228
canonical
uniprot
P30416
canonical
ensembl
ENSMUSG00000030357
resolver
ensp
ENSMUSP00000032508
resolver
enst
ENSMUST00000032508
resolver
genesymbol
Fkbp4
resolver
genesymbol_syn
Fkpb52
resolver
uniprot
Q3TVC9
resolver
uniprot_entry
FKBP4_MOUSE
resolver
uniprot_sec
Q3TVC9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by FK506. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MTAEEMKAAENGAQSAPLPLEGVDISPKQDEGVLKVIKREGTGTETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIRTRGEGYARPNDGAMVEVALEGYHKDRLFDQRELCFEVGEGESLDLPCGLEEAIQRMEKGEHSIVYLKPSYAFGSVGKERFQIPPHAELRYEVRLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSWLEYESSFSGEEMQKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHKVKAEVAAGDHPTDAEMKGERNNVAENQSRVETEA
uniprot
proteins
ec_number
5.2.1.8
uniprot
proteins
function
FUNCTION: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:11278753, ECO:0000269|PubMed:11751894, ECO:0000269|PubMed:8341706}.
uniprot
proteins
mass_dalton
51572
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by CK2 results in loss of HSP90 binding activity.
uniprot
proteins
pubmed
11278753
uniprot
proteins
pubmed
11751894
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
7693550
uniprot
proteins
pubmed
8341706
uniprot
proteins
pubmed
9195923
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11751894}. Mitochondrion {ECO:0000250|UniProtKB:Q02790}. Nucleus {ECO:0000269|PubMed:11751894, ECO:0000269|PubMed:8341706}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor. Colocalized with MAPT/TAU in the distal part of the primary cortical neurons. {ECO:0000250|UniProtKB:Q02790, ECO:0000250|UniProtKB:Q9QVC8}.
uniprot
proteins