IL12RB2
entrez
3595
canonical
uniprot
Q99665
canonical
ensembl
ENSG00000081985
resolver
ensp
ENSP00000262345
resolver
ensp
ENSP00000360039
resolver
ensp
ENSP00000442443
resolver
ensp
ENSP00000445276
resolver
ensp
ENSP00000497959
resolver
ensp
ENSP00000501329
resolver
ensp
ENSP00000512852
resolver
ensp
ENSP00000512853
resolver
ensp
ENSP00000512854
resolver
ensp
ENSP00000616419
resolver
ensp
ENSP00000616420
resolver
enst
ENST00000696754
resolver
enst
ENST00000696755
resolver
genesymbol
IL12RB2
resolver
hgnc
HGNC:5972
resolver
uniprot
A0A8Q3SIX0
resolver
uniprot
B1AN98
resolver
uniprot
B4DGA4
resolver
uniprot
B7ZB60
resolver
uniprot
B7ZKL9
resolver
uniprot
F5H7L6
resolver
uniprot
Q2M3V3
resolver
uniprot_entry
A0A8Q3SIX0_HUMAN
resolver
uniprot_entry
B4DGA4_HUMAN
resolver
uniprot_entry
B7ZB60_HUMAN
resolver
uniprot_entry
I12R2_HUMAN
resolver
uniprot_sec
B1AN98
resolver
uniprot_sec
B7ZKL9
resolver
uniprot_sec
F5H7L6
resolver
uniprot_sec
Q2M3V3
resolver
amino_acid_sequence
MAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIRVYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKYPIAEEKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLVDLYKVLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLKMRCDSLML
uniprot
proteins
function
FUNCTION: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
uniprot
proteins
mass_dalton
97135
uniprot
proteins
mutagenesis
MUTAGEN 678; /note="Y->F: No loss of STAT4 activation. No loss of SOCS3 binding."; /evidence="ECO:0000269|PubMed:10198225, ECO:0000269|PubMed:14559241, ECO:0000269|PubMed:9890938"; MUTAGEN 767; /note="Y->F: No loss of STAT4 activation. No loss of SOCS3 binding."; /evidence="ECO:0000269|PubMed:10198225, ECO:0000269|PubMed:14559241, ECO:0000269|PubMed:9890938"; MUTAGEN 800; /note="Y->F: Loss of STAT4 activation. Abolishes SOCS3 binding."; /evidence="ECO:0000269|PubMed:10198225, ECO:0000269|PubMed:14559241, ECO:0000269|PubMed:9890938"; MUTAGEN 801; /note="L->A: Abolishes in vitro STAT4 binding to a phosphorylated Y-800 peptide."; /evidence="ECO:0000269|PubMed:10415122"; MUTAGEN 802; /note="P->A: No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide."; /evidence="ECO:0000269|PubMed:10415122"; MUTAGEN 803; /note="S->A: No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide."; /evidence="ECO:0000269|PubMed:10415122"; MUTAGEN 804; /note="N->A: No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide."; /evidence="ECO:0000269|PubMed:10415122
uniprot
proteins
post_translational_modification
PTM: On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding. {ECO:0000269|PubMed:10415122, ECO:0000269|PubMed:14559241}.
uniprot
proteins
protein_family
Type 2 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
10198225
uniprot
proteins
pubmed
10415122
uniprot
proteins
pubmed
10600539
uniprot
proteins
pubmed
10663559
uniprot
proteins
pubmed
14559241
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
8943050
uniprot
proteins
pubmed
9120388
uniprot
proteins
pubmed
9890938
uniprot
proteins
sequence_length
862
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 623..643; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins