TP73
entrez
7161
canonical
uniprot
O15350
canonical
ensembl
ENSG00000078900
resolver
ensp
ENSP00000346423
resolver
ensp
ENSP00000367529
resolver
ensp
ENSP00000367534
resolver
ensp
ENSP00000367537
resolver
ensp
ENSP00000367539
resolver
ensp
ENSP00000367545
resolver
ensp
ENSP00000474322
resolver
ensp
ENSP00000474626
resolver
ensp
ENSP00000475143
resolver
ensp
ENSP00000518863
resolver
ensp
ENSP00000518864
resolver
genesymbol
TP73
resolver
genesymbol_syn
P73
resolver
hgnc
HGNC:12003
resolver
uniprot
A0A0C4DFW9
resolver
uniprot
B7Z7J4
resolver
uniprot
B7Z8Z1
resolver
uniprot
B7Z9C1
resolver
uniprot
C9J521
resolver
uniprot
O15351
resolver
uniprot
Q17RN8
resolver
uniprot
Q5TBV5
resolver
uniprot
Q5TBV6
resolver
uniprot
Q8NHW9
resolver
uniprot
Q8TDY5
resolver
uniprot
Q8TDY6
resolver
uniprot
Q9NTK8
resolver
uniprot_entry
P73_HUMAN
resolver
uniprot_sec
A0A0C4DFW9
resolver
uniprot_sec
B7Z7J4
resolver
uniprot_sec
B7Z8Z1
resolver
uniprot_sec
B7Z9C1
resolver
uniprot_sec
C9J521
resolver
uniprot_sec
O15351
resolver
uniprot_sec
Q17RN8
resolver
uniprot_sec
Q5TBV5
resolver
uniprot_sec
Q5TBV6
resolver
uniprot_sec
Q8NHW9
resolver
uniprot_sec
Q8TDY5
resolver
uniprot_sec
Q8TDY6
resolver
uniprot_sec
Q9NTK8
resolver
amino_acid_sequence
MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH
uniprot
proteins
disease_involvement
DISEASE: Ciliary dyskinesia, primary, 47, and lissencephaly (CILD47) [MIM:619466]: A form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD47 is an autosomal recessive form characterized by onset soon after birth or in early childhood. Affected individuals also have neurologic features, such as impaired intellectual development and central hypotonia, associated with structural brain abnormalities, most notably lissencephaly and thin or absent corpus callosum. No situs abnormalities have been observed. {ECO:0000269|PubMed:34077761}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761). {ECO:0000250|UniProtKB:Q9JJP2, ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:34077761}.
uniprot
proteins
mass_dalton
69623
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="T->A: Impaired phosphorylation."; /evidence="ECO:0000269|PubMed:18174154"; MUTAGEN 99; /note="Y->F: Impaired phosphorylation of isoform beta by ABL1."; /evidence="ECO:0000269|PubMed:10391251"; MUTAGEN 487; /note="Y->A: Loss of interaction with WWOX."; /evidence="ECO:0000269|PubMed:15070730"; MUTAGEN 627; /note="K->R: Strongly diminishes sumoylation but does not affect transcriptional activity."; /evidence="ECO:0000269|PubMed:10961991
uniprot
proteins
post_translational_modification
PTM: Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function. {ECO:0000269|PubMed:10961991}.; PTM: Higher levels of phosphorylation seen in the brain from patients with Huntington disease.; PTM: Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome. {ECO:0000269|PubMed:19581926, ECO:0000269|PubMed:21994467}.
uniprot
proteins
protein_family
P53 family
uniprot
proteins
pubmed
10203277
uniprot
proteins
pubmed
10362363
uniprot
proteins
pubmed
10381648
uniprot
proteins
pubmed
10391251
uniprot
proteins
pubmed
10449409
uniprot
proteins
pubmed
10961991
uniprot
proteins
pubmed
11706030
uniprot
proteins
pubmed
11753569
uniprot
proteins
pubmed
11925430
uniprot
proteins
pubmed
12890487
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15070730
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15558019
uniprot
proteins
pubmed
16461361
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17535448
uniprot
proteins
pubmed
18174154
uniprot
proteins
pubmed
18280240
uniprot
proteins
pubmed
18418051
uniprot
proteins
pubmed
19490146
uniprot
proteins
pubmed
19581926
uniprot
proteins
pubmed
21994467
uniprot
proteins
pubmed
24314664
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28291250
uniprot
proteins
pubmed
34077761
uniprot
proteins
pubmed
9288759
uniprot
proteins
pubmed
9721206
uniprot
proteins
pubmed
9802988
uniprot
proteins
sequence_length
636
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24314664}. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage.
uniprot
proteins