Arc
entrez
54323
canonical
uniprot
Q63053
canonical
ensembl
ENSRNOG00000043465
resolver
ensembl
ENSRNOG00055025242
resolver
ensembl
ENSRNOG00060023163
resolver
ensembl
ENSRNOG00065009634
resolver
ensp
ENSRNOP00000068090
resolver
ensp
ENSRNOP00000101948
resolver
ensp
ENSRNOP00055035508
resolver
ensp
ENSRNOP00060033063
resolver
ensp
ENSRNOP00065011615
resolver
enst
ENSRNOT00000076998
resolver
enst
ENSRNOT00000145814
resolver
enst
ENSRNOT00055043515
resolver
enst
ENSRNOT00060040062
resolver
enst
ENSRNOT00065015439
resolver
genesymbol
Arc
resolver
uniprot
Q62743
resolver
uniprot_entry
ARC_RAT
resolver
uniprot_sec
Q62743
resolver
amino_acid_sequence
MELDHMTTGGLHAYPAPRGGPAAKPNVILQIGKCRAEMLEHVRRTHRHLLTEVSKQVERELKGLHRSVGKLENNLDGYVPTGDSQRWKKSIKACLCRCQETIANLERWVKREMHVWREVFYRLERWADRLESMGGKYPVGSEPARHTVSVGVGGPEPYCQEADGYDYTVSPYAITPPPAAGELPEQESVGAQQYQSWVPGEDGQPSPGVDTQIFEDPREFLSHLEEYLRQVGGSEEYWLSQIQNHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYSEGTLSREAIQRELDLPQKQGEPLDQFLWRKRDLYQTLYVDAEEEEIIQYVVGTLQPKFKRFLRHPLPKTLEQLIQRGMEVQDGLEQAAEPSVTPLPTEDETEALTPALTSESVASDRTQPE
uniprot
proteins
function
FUNCTION: Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system (PubMed:29328916). ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation (PubMed:29328916). ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons (PubMed:29328916). Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory (PubMed:10818134, PubMed:17088211, PubMed:17088212, PubMed:17088213). Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis (PubMed:17088211, PubMed:17088212). Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses (PubMed:23791196). Accumulates at weaker synapses, probably to prevent their undesired enhancement (PubMed:22579289). This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material (PubMed:29328916). Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (PubMed:10818134). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (By similarity). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (By similarity). {ECO:0000250|UniProtKB:Q9WV31, ECO:0000269|PubMed:10818134, ECO:0000269|PubMed:17088211, ECO:0000269|PubMed:17088212, ECO:0000269|PubMed:17088213, ECO:0000269|PubMed:22579289, ECO:0000269|PubMed:23791196, ECO:0000269|PubMed:29328916}.
uniprot
proteins
mass_dalton
45353
uniprot
proteins
post_translational_modification
PTM: Palmitoylation anchors the protein into the membrane by allowing direct insertion into the hydrophobic core of the lipid bilayer. {ECO:0000250|UniProtKB:Q9WV31}.; PTM: Ubiquitinated by UBE3A, leading to its degradation by the proteasome, thereby promoting AMPA receptors (AMPARs) expression at synapses. Ubiquitinated by RNF216 at Lys-268 and Lys-269 limiting ARC protein levels induced by synaptic activity and thus regulating ARC-dependent forms of synaptic plasticity. {ECO:0000250|UniProtKB:Q7LC44, ECO:0000250|UniProtKB:Q9WV31}.; PTM: Phosphorylation at Ser-260 by CaMK2 prevents homooligomerization into virion-like capsids by disrupting an interaction surface essential for high-order oligomerization. Phosphorylation by CaMK2 inhibits synaptic activity. {ECO:0000250|UniProtKB:Q9WV31}.
uniprot
proteins
protein_family
ARC/ARG3.1 family
uniprot
proteins
pubmed
10570490
uniprot
proteins
pubmed
10818134
uniprot
proteins
pubmed
11226315
uniprot
proteins
pubmed
17088211
uniprot
proteins
pubmed
17088212
uniprot
proteins
pubmed
17088213
uniprot
proteins
pubmed
18614031
uniprot
proteins
pubmed
22579289
uniprot
proteins
pubmed
23791196
uniprot
proteins
pubmed
25864631
uniprot
proteins
pubmed
29328916
uniprot
proteins
pubmed
30028513
uniprot
proteins
pubmed
31080121
uniprot
proteins
pubmed
7777577
uniprot
proteins
pubmed
7857651
uniprot
proteins
pubmed
9808461
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Extracellular vesicle membrane {ECO:0000269|PubMed:29328916}; Lipid-anchor {ECO:0000250|UniProtKB:Q9WV31}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9WV31}; Lipid-anchor {ECO:0000250|UniProtKB:Q9WV31}. Synapse {ECO:0000269|PubMed:17088211, ECO:0000269|PubMed:22579289}. Postsynaptic density {ECO:0000269|PubMed:17088211}. Early endosome membrane {ECO:0000269|PubMed:17088211}. Cell projection, dendrite {ECO:0000269|PubMed:7857651, ECO:0000269|PubMed:9808461}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:7857651}. Cytoplasm, cell cortex {ECO:0000269|PubMed:7857651}. Cell projection, dendritic spine {ECO:0000269|PubMed:17088211}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9WV31}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q7LC44}. Note=Forms virion-like extracellular vesicles that are released from neurons (PubMed:29328916). Enriched in postsynaptic density of dendritic spines (PubMed:17088211). Targeted to inactive synapses following interaction with CAMK2B in the kinase inactive state (PubMed:22579289). Accumulation at weaker synapses may be required to prevent their undesired enhancement (PubMed:22579289). Associated with the cell cortex of neuronal soma and dendrites (PubMed:7857651). Associated with the sperm tail (By similarity). {ECO:0000250|UniProtKB:Q7LC44, ECO:0000250|UniProtKB:Q9WV31, ECO:0000269|PubMed:17088211, ECO:0000269|PubMed:22579289, ECO:0000269|PubMed:29328916, ECO:0000269|PubMed:7777577, ECO:0000269|PubMed:7857651}.
uniprot
proteins