GRP
entrez
2922
canonical
uniprot
P07492
canonical
ensembl
ENSG00000134443
resolver
ensp
ENSP00000256857
resolver
ensp
ENSP00000389696
resolver
ensp
ENSP00000434101
resolver
genesymbol
GRP
resolver
hgnc
HGNC:4605
resolver
uniprot
A0A140VJM7
resolver
uniprot
P07491
resolver
uniprot
P81553
resolver
uniprot
Q14454
resolver
uniprot
Q53YA0
resolver
uniprot
Q9BSY7
resolver
uniprot_entry
A0A140VJM7_HUMAN
resolver
uniprot_entry
GRP_HUMAN
resolver
uniprot_sec
P07491
resolver
uniprot_sec
P81553
resolver
uniprot_sec
Q14454
resolver
uniprot_sec
Q53YA0
resolver
uniprot_sec
Q9BSY7
resolver
amino_acid_sequence
MRGRELPLVLLALVLCLAPRGRAVPLPAGGGTVLTKMYPRGNHWAVGHLMGKKSTGESSSVSERGSLKQQLREYIRWEEAARNLLGLIEAKENRNHQPPQPKALGNQQPSWDSEDSSNFKDVGSKGKVGRLSAPGSQREGRNPQLNQQ
uniprot
proteins
function
FUNCTION: Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (By similarity). Contributes primarily to nonhistaminergic itch sensation (By similarity). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (By similarity). Contributes to the regulation of food intake (By similarity). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). {ECO:0000250|UniProtKB:P24393, ECO:0000250|UniProtKB:P63153, ECO:0000250|UniProtKB:Q8R1I2}.; FUNCTION: [Neuromedin-C]: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation. {ECO:0000250|UniProtKB:Q8R1I2}.
uniprot
proteins
mass_dalton
16213
uniprot
proteins
protein_family
Bombesin/neuromedin-B/ranatensin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
3001723
uniprot
proteins
pubmed
3003116
uniprot
proteins
pubmed
3211139
uniprot
proteins
sequence_length
148
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3211139}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:Q863C3}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q8R1I2}. Note=In neurons of the retrotrapezoid nucleus/parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex. {ECO:0000250|UniProtKB:Q8R1I2}.
uniprot
proteins