Cadm4
entrez
365216
canonical
uniprot
Q1WIM1
canonical
ensembl
ENSRNOG00000024243
resolver
ensembl
ENSRNOG00055032445
resolver
ensembl
ENSRNOG00060032999
resolver
ensembl
ENSRNOG00065033704
resolver
ensp
ENSRNOP00000026793
resolver
ensp
ENSRNOP00055046191
resolver
ensp
ENSRNOP00060047333
resolver
ensp
ENSRNOP00065047688
resolver
enst
ENSRNOT00000026793
resolver
enst
ENSRNOT00055056035
resolver
enst
ENSRNOT00060057254
resolver
enst
ENSRNOT00065057904
resolver
genesymbol
Cadm4
resolver
genesymbol_syn
Igsf4c
resolver
genesymbol_syn
Necl4
resolver
uniprot_entry
CADM4_RAT
resolver
amino_acid_sequence
MGRARRFQWPLLLLWAAAAGPGTAQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAAVLRWYRDRKELKGVSSGQENGKVWSVASTVRFRVDRKDDGGIVICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEALGETLTLPGLVSADNGTYTCEAANKHGHARALYVLVVYDPGAVVEAQTSVPYAIVGGILALLVFLIICVLVGMVWCSVRQKGSYLTHEASGLDEQGEAREAFLNGSDGHKRKEEFFI
uniprot
proteins
function
FUNCTION: Cell adhesion molecule, exhibiting calcium- and magnesium-independent cell-cell adhesion activity. In its palmitoylated form, is required for proper oligodendrocyte maturation and myelination in CNS via its association with other cell adhesion molecules such as CADM2/3 and MAG. May have tumor-suppressor activity. {ECO:0000250|UniProtKB:Q8NFZ8, ECO:0000250|UniProtKB:Q8R464}.
uniprot
proteins
mass_dalton
42781
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q8R464}.; PTM: Palmitoylation, specifically at Cys-347 catalyzed by ZDHHC3, is essential for its localization to the plasma membrane and protein stability This localization is crucial for its function in CNS myelination, particularly through its associations with other cell adhesion molecules like CADM2/3 and MAG. {ECO:0000250|UniProtKB:Q8R464}.
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24090084
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8R464}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8R464}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 325..345; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins