Ddx39a
entrez
89827
canonical
uniprot
Q5U216
canonical
ensembl
ENSRNOG00000004373
resolver
ensembl
ENSRNOG00055008421
resolver
ensembl
ENSRNOG00060013193
resolver
ensembl
ENSRNOG00065009645
resolver
ensp
ENSRNOP00000068949
resolver
ensp
ENSRNOP00000110804
resolver
ensp
ENSRNOP00055011464
resolver
ensp
ENSRNOP00060017850
resolver
ensp
ENSRNOP00065011662
resolver
enst
ENSRNOT00000090312
resolver
enst
ENSRNOT00055014273
resolver
enst
ENSRNOT00060022528
resolver
enst
ENSRNOT00065015486
resolver
genesymbol
Ddx39a
resolver
genesymbol_syn
Ddx39
resolver
genesymbol_syn
Ddxl
resolver
uniprot
O70498
resolver
uniprot_entry
DX39A_RAT
resolver
uniprot_sec
O70498
resolver
amino_acid_sequence
MAEQDVENELLDYDEDEEPQVPQESTPAPPKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQIEPINGQVSVLVMCHTRELAFQISKEYERFSKYMPSVKVSVFFGGLSIKKDEDVLKKNCPHVVVGTPGRILALVRSRSLNLRNVKHFVLDECDKMLEQLDMRRDVQEIFRLTPHEKQCMMFSATLSKEIRPVCRKFMQDPMEVFVDDETKLTLHGLQQYYVKLKDSEKNRKLFDLLDVLEFNQVVIFVKSVQRCMALAQLLVEQNFPAIAIHRGMAQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAVTFVSDENDAKILNDVQDRFEVNVAELPEEIDISTYIEQSR
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing. Regulates nuclear mRNA export to the cytoplasm through association with ECD. Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX. Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression. Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA. {ECO:0000250|UniProtKB:O00148}.
uniprot
proteins
mass_dalton
49109
uniprot
proteins
post_translational_modification
PTM: SUMOylated by RANBP2; SUMOylation modification affects its ability to bind RNA. {ECO:0000250|UniProtKB:O00148}.
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
protein_family
DECD subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
427
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O00148}. Cytoplasm {ECO:0000250|UniProtKB:O00148}. Note=Can translocate to the cytoplasm in the presence of MX1. Accumulates in the cytoplasm upon infection with chikungunya virus. {ECO:0000250|UniProtKB:O00148}.
uniprot
proteins