ENOX2
entrez
10495
canonical
uniprot
Q16206
canonical
ensembl
ENSG00000165675
resolver
ensp
ENSP00000337146
resolver
ensp
ENSP00000359965
resolver
ensp
ENSP00000359973
resolver
ensp
ENSP00000377890
resolver
ensp
ENSP00000509235
resolver
ensp
ENSP00000519773
resolver
ensp
ENSP00000570574
resolver
ensp
ENSP00000607213
resolver
ensp
ENSP00000607218
resolver
ensp
ENSP00000607219
resolver
enst
ENST00000686943
resolver
enst
ENST00000714528
resolver
genesymbol
ENOX2
resolver
genesymbol_syn
COVA1
resolver
hgnc
HGNC:2259
resolver
uniprot
A0A8I5KRI1
resolver
uniprot
A0AAQ5BI24
resolver
uniprot
A8K197
resolver
uniprot
A8K1C2
resolver
uniprot
Q32ND0
resolver
uniprot
Q5VTJ1
resolver
uniprot
Q5VTJ2
resolver
uniprot
Q8WUX0
resolver
uniprot
Q9NTP6
resolver
uniprot
Q9UH82
resolver
uniprot_entry
A0A8I5KRI1_HUMAN
resolver
uniprot_entry
A0AAQ5BI24_HUMAN
resolver
uniprot_entry
ENOX2_HUMAN
resolver
uniprot_entry
Q32ND0_HUMAN
resolver
uniprot_sec
A8K197
resolver
uniprot_sec
A8K1C2
resolver
uniprot_sec
Q5VTJ1
resolver
uniprot_sec
Q5VTJ2
resolver
uniprot_sec
Q8WUX0
resolver
uniprot_sec
Q9NTP6
resolver
uniprot_sec
Q9UH82
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the antitumor sulfonylurea LY181984, the vabilloid capsaicin, and retinoids. {ECO:0000269|PubMed:11888291, ECO:0000269|PubMed:9046026, ECO:0000269|PubMed:9932650}.
uniprot
proteins
amino_acid_sequence
MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPILPDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGIISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWKFCGFEGLKLT
uniprot
proteins
ec_number
1.-.-.-
uniprot
proteins
function
FUNCTION: May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. {ECO:0000269|PubMed:12356293, ECO:0000269|PubMed:9932650}.
uniprot
proteins
mass_dalton
70082
uniprot
proteins
mutagenesis
MUTAGEN 396; /note="M->A: No effect on activity but response to capsaicin is lost."; /evidence="ECO:0000269|PubMed:11888291"; MUTAGEN 505; /note="C->A: No effect on activity."; /evidence="ECO:0000269|PubMed:11888291"; MUTAGEN 510; /note="C->A: Loss of activity."; /evidence="ECO:0000269|PubMed:11888291"; MUTAGEN 546; /note="H->A: Loss of activity."; /evidence="ECO:0000269|PubMed:11888291"; MUTAGEN 558; /note="C->A: Period length of activity extended to 42 minutes."; /evidence="ECO:0000269|PubMed:11888291"; MUTAGEN 562; /note="H->A: Loss of activity."; /evidence="ECO:0000269|PubMed:11888291"; MUTAGEN 569; /note="C->A: Loss of activity."; /evidence="ECO:0000269|PubMed:11888291"; MUTAGEN 575; /note="C->A: Period length of activity extended to 36 minutes."; /evidence="ECO:0000269|PubMed:11888291"; MUTAGEN 592; /note="G->V: Loss of activity."; /evidence="ECO:0000269|PubMed:11888291"; MUTAGEN 602; /note="C->A: Period length of activity extended to 36 minutes."; /evidence="ECO:0000269|PubMed:11888291
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:8150545}.
uniprot
proteins
protein_family
ENOX family
uniprot
proteins
pubmed
10354495
uniprot
proteins
pubmed
11412089
uniprot
proteins
pubmed
11437345
uniprot
proteins
pubmed
11488599
uniprot
proteins
pubmed
11888291
uniprot
proteins
pubmed
11941450
uniprot
proteins
pubmed
12356293
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
23033978
uniprot
proteins
pubmed
39406892
uniprot
proteins
pubmed
8150545
uniprot
proteins
pubmed
9046026
uniprot
proteins
pubmed
9932650
uniprot
proteins
sequence_length
610
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated.
uniprot
proteins