P09022
uniprot
P09022
canonical
amino_acid_sequence
MNSFLEYPILGSGDSGTCSARAYPSDHGITTFQSCAVSANSCGGDDRFLVGRGVQISSPHHHHHHHHHHHPQTATYQTSGNLGISYSHSSCGPSYGAQNFSAPYGPYGLNQEADVSGGYPPCAPAVYSGNLSTPMVQHHHHHQGYAGGTVGSPQYIHHSYGQEQQTLALATYNNSLSPLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTGKVGEYGYVGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATPPGSDEKTEESSEKSSPSPSAPSPASSTSDTLTTSH
uniprot
proteins
function
FUNCTION: Sequence-specific transcription factor (PubMed:29465778). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (By similarity). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (PubMed:29465778). {ECO:0000250|UniProtKB:P49639, ECO:0000250|UniProtKB:Q90423, ECO:0000269|PubMed:29465778}.; FUNCTION: The homeobox domain presumably directs sequence-specific DNA binding. The N-terminal portion of ERA-1-993 may be involved in interactions with one or more other regulatory proteins. Such an interaction could regulate either the DNA-binding activity or the transcriptional regulatory activity of ERA-1-993.; FUNCTION: The homeoboxless ERA-1-399 protein could act as a competitive inhibitor of the ERA-1-993 protein by competing for interaction with regulatory protein(s) while being unable to bind to DNA.
uniprot
proteins
mass_dalton
36037
uniprot
proteins
mutagenesis
MUTAGEN 1..224; /note="Missing: Loss of interaction with OGT."; /evidence="ECO:0000269|PubMed:29465778"; MUTAGEN 1..40; /note="Missing: Interacts with OGT."; /evidence="ECO:0000269|PubMed:29465778"; MUTAGEN 60..142; /note="Missing: Loss of interaction with OGT."; /evidence="ECO:0000269|PubMed:29465778"; MUTAGEN 60..70; /note="Missing: Loss of interaction with OGT."; /evidence="ECO:0000269|PubMed:29465778"; MUTAGEN 71..199; /note="Missing: Loss of interaction with OGT."; /evidence="ECO:0000269|PubMed:29465778"; MUTAGEN 203..204; /note="WM->AA: Interacts with OGT."; /evidence="ECO:0000269|PubMed:29465778"; MUTAGEN 225..284; /note="Missing: Interacts with OGT."; /evidence="ECO:0000269|PubMed:29465778"; MUTAGEN 272..275; /note="WFQN->SVAA: Interacts with OGT."; /evidence="ECO:0000269|PubMed:29465778
uniprot
proteins
post_translational_modification
PTM: Glycosylated by OGT. {ECO:0000269|PubMed:29465778}.
uniprot
proteins
protein_family
Antp homeobox family
uniprot
proteins
protein_family
Labial subfamily
uniprot
proteins
pubmed
2569969
uniprot
proteins
pubmed
2891503
uniprot
proteins
pubmed
2906112
uniprot
proteins
pubmed
29465778
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29465778}.
uniprot
proteins