PRKG1
entrez
5592
canonical
uniprot
Q13976
canonical
ensembl
ENSG00000185532
resolver
ensp
ENSP00000363087
resolver
ensp
ENSP00000363092
resolver
ensp
ENSP00000384200
resolver
enst
ENST00000373976
resolver
genesymbol
PRKG1
resolver
genesymbol_syn
PRKG1B
resolver
genesymbol_syn
PRKGR1A
resolver
genesymbol_syn
PRKGR1B
resolver
hgnc
HGNC:9414
resolver
uniprot
A5YM56
resolver
uniprot
A6NFM3
resolver
uniprot
B1ALS0
resolver
uniprot
B3KSF3
resolver
uniprot
E2PU10
resolver
uniprot
P14619
resolver
uniprot
Q5JP05
resolver
uniprot
Q5JSJ6
resolver
uniprot
Q6P5T7
resolver
uniprot_entry
B1ALS0_HUMAN
resolver
uniprot_entry
KGP1_HUMAN
resolver
uniprot_sec
A5YM56
resolver
uniprot_sec
A6NFM3
resolver
uniprot_sec
B3KSF3
resolver
uniprot_sec
E2PU10
resolver
uniprot_sec
P14619
resolver
uniprot_sec
Q5JP05
resolver
uniprot_sec
Q5JSJ6
resolver
uniprot_sec
Q6P5T7
resolver
activity_regulation
ACTIVITY REGULATION: In the absence of cGMP, PRKG1 activity is suppressed by autoinhibitory contacts.
uniprot
proteins
amino_acid_sequence
MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF
uniprot
proteins
disease_involvement
DISEASE: Aortic aneurysm, familial thoracic 8 (AAT8) [MIM:615436]: A disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. {ECO:0000269|PubMed:23910461}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.12
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase that acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling also alters gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. {ECO:0000269|PubMed:10567269, ECO:0000269|PubMed:11162591, ECO:0000269|PubMed:11723116, ECO:0000269|PubMed:12082086, ECO:0000269|PubMed:14608379, ECO:0000269|PubMed:15194681, ECO:0000269|PubMed:16990611, ECO:0000269|PubMed:8182057}.
uniprot
proteins
mass_dalton
76364
uniprot
proteins
mutagenesis
MUTAGEN 12; /note="L->A: Loss of binding to PPP1R12A."; /evidence="ECO:0000269|PubMed:10567269"; MUTAGEN 19; /note="I->A: Loss of binding to PPP1R12A."; /evidence="ECO:0000269|PubMed:10567269"; MUTAGEN 26; /note="L->P: Loss of binding to PPP1R12A."; /evidence="ECO:0000269|PubMed:10567269"; MUTAGEN 33; /note="I->A: Loss of binding to PPP1R12A."; /evidence="ECO:0000269|PubMed:10567269"; MUTAGEN 40; /note="L->A: Loss of binding to PPP1R12A."; /evidence="ECO:0000269|PubMed:10567269"; MUTAGEN 281; /note="L->A: Reduces cGMP binding affinity."; /evidence="ECO:0000269|PubMed:24239458"; MUTAGEN 282; /note="R->A: Reduces cGMP binding affinity."; /evidence="ECO:0000269|PubMed:24239458"; MUTAGEN 302; /note="T->A: Reduces cGMP binding affinity."; /evidence="ECO:0000269|PubMed:24239458"; MUTAGEN 336; /note="Y->A: Reduces cGMP binding affinity."; /evidence="ECO:0000269|PubMed:24239458
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation increases kinase activity.; PTM: 65 kDa monomer is produced by proteolytic cleavage. {ECO:0000250}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
cGMP subfamily
uniprot
proteins
pubmed
10567269
uniprot
proteins
pubmed
11162591
uniprot
proteins
pubmed
11723116
uniprot
proteins
pubmed
12082086
uniprot
proteins
pubmed
14608379
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15194681
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16131665
uniprot
proteins
pubmed
16990611
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17904578
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18782776
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20716671
uniprot
proteins
pubmed
20826808
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21402151
uniprot
proteins
pubmed
21526164
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23910461
uniprot
proteins
pubmed
24239458
uniprot
proteins
pubmed
25271401
uniprot
proteins
pubmed
2792381
uniprot
proteins
pubmed
8182057
uniprot
proteins
pubmed
8613202
uniprot
proteins
pubmed
9192852
uniprot
proteins
sequence_length
671
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Colocalized with TRPC7 in the plasma membrane. {ECO:0000250}.
uniprot
proteins