Cdx2
entrez
12591
canonical
uniprot
P43241
canonical
ensembl
ENSMUSG00000029646
resolver
ensp
ENSMUSP00000031650
resolver
enst
ENSMUST00000031650
resolver
genesymbol
Cdx2
resolver
genesymbol_syn
Cdx-2
resolver
uniprot
Q543L9
resolver
uniprot_entry
CDX2_MOUSE
resolver
uniprot_entry
Q543L9_MOUSE
resolver
amino_acid_sequence
MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAATANLDSAQSPGPSWPTAYGAPLREDWNGYAPGGAAAANAVAHGLNGGSPAAAMGYSSPAEYHAHHHPHHHPHHPAASPSCASGLLQTLNLGPPGPAATAAAEQLSPSGQRRNLCEWMRKPAQQSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHFSRYITIRRKSELAATLGLSERQVKIWFQNRRAKERKIKKKQQQQQQQQQQQPPQPPPQPSQPQPGALRSVPEPLSPVTSLQGSVPGSVPGVLGPAGGVLNSTVTQ
uniprot
proteins
function
FUNCTION: Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (PubMed:16027724, PubMed:9933478). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (PubMed:7935448). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (PubMed:9933478). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (PubMed:16027724). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (PubMed:9512360). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (By similarity). {ECO:0000250|UniProtKB:Q04649, ECO:0000250|UniProtKB:Q99626, ECO:0000269|PubMed:16027724, ECO:0000269|PubMed:7935448, ECO:0000269|PubMed:9512360, ECO:0000269|PubMed:9933478}.
uniprot
proteins
mass_dalton
33476
uniprot
proteins
mutagenesis
MUTAGEN 60; /note="S->A: Reduced phosphorylation. Does not affect nuclear localization."; /evidence="ECO:0000269|PubMed:11729123
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation by the proteasome. {ECO:0000269|PubMed:16027724}.; PTM: Phosphorylation at Ser-60 reduces transactivation capacity (PubMed:11729123). Phosphorylation at Ser-281 reduces transactivation capacity and increases ubiquitin-dependent proteasome degradation (PubMed:16027724). {ECO:0000269|PubMed:11729123, ECO:0000269|PubMed:16027724}.
uniprot
proteins
protein_family
Caudal homeobox family
uniprot
proteins
pubmed
11729123
uniprot
proteins
pubmed
16027724
uniprot
proteins
pubmed
1671571
uniprot
proteins
pubmed
7910823
uniprot
proteins
pubmed
7935448
uniprot
proteins
pubmed
9512360
uniprot
proteins
pubmed
9933478
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11729123, ECO:0000269|PubMed:7910823}.
uniprot
proteins