Tmem33
entrez
59303
canonical
uniprot
Q9Z142
canonical
ensembl
ENSRNOG00000002254
resolver
ensembl
ENSRNOG00055018414
resolver
ensembl
ENSRNOG00060014529
resolver
ensembl
ENSRNOG00065013507
resolver
ensp
ENSRNOP00000003128
resolver
ensp
ENSRNOP00000097007
resolver
ensp
ENSRNOP00055025242
resolver
ensp
ENSRNOP00060019815
resolver
ensp
ENSRNOP00065017255
resolver
enst
ENSRNOT00000003128
resolver
enst
ENSRNOT00000110302
resolver
enst
ENSRNOT00055031283
resolver
enst
ENSRNOT00060024878
resolver
enst
ENSRNOT00065022233
resolver
genesymbol
Tmem33
resolver
genesymbol_syn
Db83
resolver
uniprot
A0A0H2UHA6
resolver
uniprot_entry
A0A0H2UHA6_RAT
resolver
uniprot_entry
TMM33_RAT
resolver
amino_acid_sequence
MADTTPNGPQGAGAVQFMMTNKLDTAMWLSRLFTVYCSALFVLPLLGLHEAASFYQRALLANALTSALRLHQRLPHFQLSRAFLAQALLEDSCHYLLYSLIFVNSYPVTMSIFPVLLFSLLHAATYTKKVLDAKGSNSLPLLRSVLDKLSTNQQNILKFIACNEIFLMPATVFMLFSGQGSLLQPFIYYRFLTLRYSSRRNPYCRNLFNELRIVVEHIIMKPSCPLFVRRLCLQSIAFISRLAPTVA
uniprot
proteins
function
FUNCTION: Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (By similarity). Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling. Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis. Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (By similarity). {ECO:0000250|UniProtKB:P57088, ECO:0000250|UniProtKB:Q9CR67}.
uniprot
proteins
mass_dalton
27983
uniprot
proteins
protein_family
PER33/POM33 family
uniprot
proteins
pubmed
9872456
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P57088}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000250|UniProtKB:P57088}. Nucleus envelope {ECO:0000250|UniProtKB:P57088}. Note=Co-localizes with RTN4 at the ER sheets. {ECO:0000250|UniProtKB:P57088}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 101..121; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 156..176; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins