Parp16
entrez
214424
canonical
uniprot
Q7TMM8
canonical
ensembl
ENSMUSG00000032392
resolver
ensp
ENSMUSP00000070098
resolver
ensp
ENSMUSP00000149927
resolver
ensp
ENSMUSP00000150318
resolver
ensp
ENSMUSP00000247057
resolver
enst
ENSMUST00000069000
resolver
enst
ENSMUST00000213396
resolver
enst
ENSMUST00000216702
resolver
genesymbol
Parp16
resolver
genesymbol_syn
Artd15
resolver
uniprot
Q3V031
resolver
uniprot
Q8CC71
resolver
uniprot_entry
PAR16_MOUSE
resolver
uniprot_sec
Q3V031
resolver
uniprot_sec
Q8CC71
resolver
activity_regulation
ACTIVITY REGULATION: In absence of activation signal, PARP16 is autoinhibited by the PARP alpha-helical domain (also named HD region), which prevents effective NAD(+)-binding. Activity is highly stimulated by signals, which unfold the PARP alpha-helical domain, relieving autoinhibition. {ECO:0000250|UniProtKB:Q9UGN5}.
uniprot
proteins
amino_acid_sequence
MQLSNRAAAREAASRDVLAADLRCSLFASALQSYKRDSVLRPFPASYARHDCKDFEALLADTGRLPNLKELLQSSRDTDKQAWDLVSWILSSKILTIHSAKKAEFEKIQQLTGAPHTPVPTPDFLFEIEYFDPANSRFYETKGERDLIYAFHGSRLENFHSIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVIDHPDVKCQIKKKDSKEIDRSRARIKHSEGGEIPPKYFVVTNNQLLRVKYLLVYSQKQPKRASSQLSWLSSHWFVIMMSLYLLLLLIVSVTNSSVFHHFWNRVKR
uniprot
proteins
ec_number
2.4.2.-
uniprot
proteins
function
FUNCTION: Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes. Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading. Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2. Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases. {ECO:0000250|UniProtKB:Q8N5Y8}.
uniprot
proteins
mass_dalton
36764
uniprot
proteins
post_translational_modification
PTM: Auto-mono-ADP-ribosylated. {ECO:0000250|UniProtKB:Q8N5Y8}.
uniprot
proteins
protein_family
ARTD/PARP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8N5Y8}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8N5Y8}.
uniprot
proteins
transmembrane_region
TRANSMEM 288..308; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins