Hormad1
entrez
67981
canonical
uniprot
Q9D5T7
canonical
ensembl
ENSMUSG00000028109
resolver
ensp
ENSMUSP00000029754
resolver
ensp
ENSMUSP00000088303
resolver
ensp
ENSMUSP00000102772
resolver
ensp
ENSMUSP00000127180
resolver
ensp
ENSMUSP00000352810
resolver
genesymbol
Hormad1
resolver
genesymbol_syn
Nohma
resolver
uniprot
Q9CUF3
resolver
uniprot
Q9D473
resolver
uniprot_entry
HORM1_MOUSE
resolver
uniprot_sec
Q9CUF3
resolver
uniprot_sec
Q9D473
resolver
amino_acid_sequence
MATMQLQRTASLSALVFPNKISTEHQSLMFVKRLLAVSVSCITYLRGIFPERAYGTRYLDDLCVKILKEDKNCPGSSQLVKWMLGCYDALQKKYLRMIILAVYTNPGDPQTISECYQFKFKYTKNGPIMDFISKNQNNKSSTTSADTKKASILLIRKIYVLMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFDGDPTYLNVGEVPTPFHTFRLKVTTEKERMENIDSTILKPKESKTQFEKILMDKDDVEDENHNNFDIKTKMNEQNENSGASEIKEPNLDCKEEETMQFKKSQSPSISHCQVEQLVSKTSELDVSESKTRSGKIFQSKMVNGNNQQGQTSKENRKRSLRQFRKTVLHVLESSQESVLKKRRVSEPKEHT
uniprot
proteins
function
FUNCTION: Plays a key role in meiotic progression (PubMed:19686734, PubMed:21079677, PubMed:21478856). Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends (PubMed:19686734, PubMed:21079677). Promotes synaptonemal-complex formation independently of its role in homology search (PubMed:19686734, PubMed:21079677). Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (PubMed:21478856). {ECO:0000269|PubMed:19686734, ECO:0000269|PubMed:21079677, ECO:0000269|PubMed:21478856}.
uniprot
proteins
mass_dalton
44933
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-375 in a SPO11-dependent manner. {ECO:0000269|PubMed:19686734, ECO:0000269|PubMed:22346761}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15567723
uniprot
proteins
pubmed
15999985
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19686734
uniprot
proteins
pubmed
19851446
uniprot
proteins
pubmed
21079677
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21478856
uniprot
proteins
pubmed
22346761
uniprot
proteins
pubmed
22549958
uniprot
proteins
pubmed
27723721
uniprot
proteins
pubmed
30272023
uniprot
proteins
pubmed
30746471
uniprot
proteins
sequence_length
392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:19686734, ECO:0000269|PubMed:19851446}. Chromosome {ECO:0000269|PubMed:19686734, ECO:0000269|PubMed:19851446, ECO:0000269|PubMed:22346761, ECO:0000269|PubMed:22549958, ECO:0000269|PubMed:27723721, ECO:0000269|PubMed:30272023, ECO:0000269|PubMed:30746471}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis (PubMed:19686734, PubMed:19851446, PubMed:27723721). Accumulates on the chromosomes during the leptotene to zygotene stages of meiotic prophase I (PubMed:19686734, PubMed:19851446, PubMed:27723721). As germ cells progress into the pachytene stage, disappears from the synapsed chromosomal regions (PubMed:19686734, PubMed:19851446, PubMed:27723721). Once the chromosomes desynapse during the diplotene stage, it again accumulates on the chromosome axis of the desynapsed homologs (PubMed:19686734, PubMed:19851446, PubMed:27723721). TRIP13 is required for depletion from synapsed chromosomes (PubMed:19851446). The expression of the phosphorylated form at Ser-375 is restricted to unsynapsed chromosomal regions (PubMed:22346761). {ECO:0000269|PubMed:19686734, ECO:0000269|PubMed:19851446, ECO:0000269|PubMed:22346761, ECO:0000269|PubMed:27723721}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19686734}.
uniprot
proteins