Ncaph2
entrez
300149
canonical
uniprot
Q4V8I2
canonical
ensembl
ENSRNOG00000009598
resolver
ensp
ENSRNOP00000052664
resolver
ensp
ENSRNOP00000073049
resolver
ensp
ENSRNOP00000098486
resolver
enst
ENSRNOT00000055808
resolver
genesymbol
Ncaph2
resolver
uniprot_entry
CNDH2_RAT
resolver
amino_acid_sequence
MNFIEAALLIQGSACVYSKKVEYLYSLVYQALDFISGKRRAKQLSLVQEDGSNRAVNSGTPCETEDEFLSLDDFPDSRANVDLKNDQASSELLIIPLLPMALVAPDEVEKSSNPLYSCQGEVLASRKDFRMNTCTPDPRGSFMLDPVGMCPVEPVDVHPMPRSQKDAEEAEEQPMAVSRNGSPVSVRSISQEPDGPALSSGDEDAEDVAELPEVALEPAEPRTSQQTAILPRRYMLRERQGAPEPASQPQETPDPWQSLDPFDSLDSKLFQKGKPYSVPPGVEEAPGQKRKRKGATKLQDFHQWYLDAYAEHPDGRRARRKGPSFADMEVLYWKHVKEQLETLQKLRRRKMTERWLPGAKQDLWPAEEERLEEPLEDLGVADDFLEAEEYVEESEGVMPREAAGLDAEAIPESLKYEELVRRNVELFIATSQKFIQETELSQRIRDWEDTIQPLLQEQEQHVPFDIHTYGDQLVSRFPQLNEWCPFAELVAGQPAFEVCRSMLASLQLANDYTVEITQQPGLEAAVDTMSLRLLTHQRAHMRFQTYAAPSMAQP
uniprot
proteins
function
FUNCTION: Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (By similarity). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (By similarity). {ECO:0000250|UniProtKB:Q6IBW4, ECO:0000250|UniProtKB:Q8BSP2}.
uniprot
proteins
mass_dalton
62637
uniprot
proteins
protein_family
CND2 H2 (condensin-2 subunit 2) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
554
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins