Popdc1
entrez
23828
canonical
uniprot
Q9ES83
canonical
ensembl
ENSMUSG00000071317
resolver
ensp
ENSMUSP00000093382
resolver
ensp
ENSMUSP00000198283
resolver
ensp
ENSMUSP00000198286
resolver
enst
ENSMUST00000095715
resolver
genesymbol
Popdc1
resolver
genesymbol_syn
Bves
resolver
genesymbol_syn
Pop1
resolver
uniprot
A2RS91
resolver
uniprot
Q8C8L3
resolver
uniprot_entry
POPD1_MOUSE
resolver
uniprot_sec
A2RS91
resolver
uniprot_sec
Q8C8L3
resolver
amino_acid_sequence
MNSTESIPLAQSTVAGFTSELESLTPVPSNETTCENWREIHHLVFHVANVCFAVGLLIPTTLHLHMILLRVMLSLGCTLYVVWATLYRCALDVMIWNSVFLGINILHLSYLLYKKRPVKIEKELGGVYHRLFEPLRVPPDLFRRLTGQFCMIQTLKRGQVYATEDKTSVDDRLSILLKGRMKVSYRGHFLHNIYPCAFIDSPEFRSTQMHKGEKFQVTIVADDNCRFLCWSRERLTYFLESEPFLYEIFRYLIGKDITNKLYSLNDPTLNDKKVKKLEPQMSLCTQISMLEMRNSITSSSDGEDGLHHFLRGSSSTASLPMSSPQQRASAKMKPIEEGVEDDDEVFVSPDALKVHQLP
uniprot
proteins
function
FUNCTION: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3 (PubMed:20057356). Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT (PubMed:18541910). Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (PubMed:11839816). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury (PubMed:24066022). {ECO:0000250|UniProtKB:Q8NE79, ECO:0000269|PubMed:10882522, ECO:0000269|PubMed:11839816, ECO:0000269|PubMed:16188940, ECO:0000269|PubMed:18541910, ECO:0000269|PubMed:20057356, ECO:0000269|PubMed:22354168, ECO:0000269|PubMed:24066022}.
uniprot
proteins
mass_dalton
41016
uniprot
proteins
mutagenesis
MUTAGEN 200; /note="D->A: Almost abolishes cAMP-binding. Interaction with KCNK2 is not inhibited by cAMP."; /evidence="ECO:0000269|PubMed:22354168"; MUTAGEN 202; /note="P->A: No effect on cAMP-binding."; /evidence="ECO:0000269|PubMed:22354168"; MUTAGEN 203; /note="E->A: Decreases cAMP-binding."; /evidence="ECO:0000269|PubMed:22354168"; MUTAGEN 217; /note="V->F: Decreases cAMP-binding."; /evidence="ECO:0000269|PubMed:22354168
uniprot
proteins
protein_family
Popeye family
uniprot
proteins
pubmed
10208750
uniprot
proteins
pubmed
10882522
uniprot
proteins
pubmed
11839816
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16188940
uniprot
proteins
pubmed
18541910
uniprot
proteins
pubmed
20057356
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22354168
uniprot
proteins
pubmed
24066022
uniprot
proteins
pubmed
26642364
uniprot
proteins
sequence_length
358
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lateral cell membrane {ECO:0000250|UniProtKB:Q8NE79}. Cell junction, tight junction {ECO:0000269|PubMed:16188940}. Membrane {ECO:0000269|PubMed:22354168}; Multi-pass membrane protein {ECO:0000305}. Cell membrane, sarcolemma {ECO:0000269|PubMed:24066022}. Membrane, caveola {ECO:0000269|PubMed:24066022}. Note=Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Detected at cell-cell contact but never observed at the free surface of epithelial cells (By similarity). Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle. {ECO:0000269|PubMed:16188940, ECO:0000269|PubMed:20057356}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins