Ift81
entrez
12589
canonical
uniprot
O35594
canonical
ensembl
ENSMUSG00000029469
resolver
ensp
ENSMUSP00000031426
resolver
ensp
ENSMUSP00000267119
resolver
ensp
ENSMUSP00000267123
resolver
ensp
ENSMUSP00000267127
resolver
genesymbol
Ift81
resolver
genesymbol_syn
Cdv-1
resolver
genesymbol_syn
Cdv1
resolver
uniprot
Q8R4W2
resolver
uniprot
Q9CSA1
resolver
uniprot
Q9EQM1
resolver
uniprot_entry
IFT81_MOUSE
resolver
uniprot_sec
Q8R4W2
resolver
uniprot_sec
Q9CSA1
resolver
uniprot_sec
Q9EQM1
resolver
amino_acid_sequence
MSDQIKFIVDSLNKEPFKKNYNLITFDSLGPMQLLQVLNDVLAEIDPKQDVDIREEMPEQTAKRMLNLLGILKYKPPGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRSNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKECEQLKTSGFSTAEIRRDISAMEEEKDQLMKRVERLKKRVETVQNHQRMLKIARQLRVEKEREEFLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRHAAADAKPESLMKRLEEEIKFNSYMVTEKFPKELESKKKELHFLQKVVSEPAMGHSDLLELETKVNEVNTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQETKEKLASLEREVLVKTNQTREFDGTEVLKGDEFKRYVSKLRSKSTVFKKKHQIIAEFKAEFGLLQRTEELLKQRQETIQHQLRTIEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLNSLVSEKKSALAPVIKELRQLRQKCQELTQECDEKKAQYDSCAAGLESNRSKLEQEVRGLREECLQEESKYHYTNCMIKNLEVELRRATDEMKAYVSSDQQEKRKAIREQYTKNITEQENLGKKLREKQKAVRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSPASIGQVIQEGGEDRLVL
uniprot
proteins
function
FUNCTION: Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling (By similarity). Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella (PubMed:32233951). {ECO:0000250|UniProtKB:Q8WYA0, ECO:0000269|PubMed:32233951}.; FUNCTION: [Isoform CDV-1]: May be involved in cardiac hypertrophy caused by carnitine deficiency. {ECO:0000269|PubMed:10210276}.; FUNCTION: [Isoform CDV-1R]: May play a role in development of the testis and spermatogenesis. {ECO:0000269|PubMed:12549821}.
uniprot
proteins
mass_dalton
79285
uniprot
proteins
post_translational_modification
PTM: Palmitoylated by ZDHC5. {ECO:0000269|PubMed:41182177}.
uniprot
proteins
protein_family
IFT81 family
uniprot
proteins
pubmed
10210276
uniprot
proteins
pubmed
11130971
uniprot
proteins
pubmed
12549821
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19253336
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23055941
uniprot
proteins
pubmed
23810713
uniprot
proteins
pubmed
32233951
uniprot
proteins
pubmed
34792097
uniprot
proteins
pubmed
41182177
uniprot
proteins
pubmed
9187371
uniprot
proteins
sequence_length
676
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:19253336}. Cytoplasm {ECO:0000269|PubMed:32233951, ECO:0000269|PubMed:41182177}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8WYA0}.
uniprot
proteins