CBX1
entrez
10951
canonical
uniprot
P83916
canonical
ensembl
ENSG00000108468
resolver
ensp
ENSP00000225603
resolver
ensp
ENSP00000377060
resolver
ensp
ENSP00000534384
resolver
ensp
ENSP00000534385
resolver
ensp
ENSP00000534386
resolver
ensp
ENSP00000534388
resolver
ensp
ENSP00000592278
resolver
ensp
ENSP00000592279
resolver
ensp
ENSP00000592281
resolver
ensp
ENSP00000592282
resolver
ensp
ENSP00000592283
resolver
enst
ENST00000225603
resolver
enst
ENST00000393408
resolver
enst
ENST00000864325
resolver
enst
ENST00000864326
resolver
enst
ENST00000864327
resolver
enst
ENST00000864329
resolver
enst
ENST00000922219
resolver
enst
ENST00000922220
resolver
enst
ENST00000922222
resolver
enst
ENST00000922223
resolver
enst
ENST00000922224
resolver
genesymbol
CBX1
resolver
genesymbol_syn
CBX
resolver
hgnc
HGNC:1551
resolver
uniprot
P23197
resolver
uniprot
Q6IBN6
resolver
uniprot_entry
CBX1_HUMAN
resolver
uniprot_entry
Q6IBN6_HUMAN
resolver
uniprot_sec
P23197
resolver
amino_acid_sequence
MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDCPDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHSYPSEDDDKKDDKN
uniprot
proteins
function
FUNCTION: Component of heterochromatin, which recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression (PubMed:41094145). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me) (PubMed:16127177). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph) (PubMed:16127177). Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane (By similarity). {ECO:0000250|UniProtKB:P83917, ECO:0000269|PubMed:16127177, ECO:0000269|PubMed:41094145}.
uniprot
proteins
mass_dalton
21418
uniprot
proteins
mutagenesis
MUTAGEN 161; /note="I->E: Abolishes homodimer formation and binding to EMSY."; /evidence="ECO:0000269|PubMed:15947784
uniprot
proteins
post_translational_modification
PTM: Not phosphorylated.; PTM: Ubiquitinated. {ECO:0000269|PubMed:20498703}.
uniprot
proteins
pubmed
10202156
uniprot
proteins
pubmed
10460410
uniprot
proteins
pubmed
14651845
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15899859
uniprot
proteins
pubmed
15947784
uniprot
proteins
pubmed
16127177
uniprot
proteins
pubmed
16615912
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
19880879
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20498703
uniprot
proteins
pubmed
20562864
uniprot
proteins
pubmed
20850016
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21346195
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23542155
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25750265
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
26721387
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28977666
uniprot
proteins
pubmed
41094145
uniprot
proteins
pubmed
9169582
uniprot
proteins
sequence_length
185
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10460410, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9169582}. Note=Unassociated with chromosomes during mitosis.
uniprot
proteins