SOCS1
entrez
8651
canonical
uniprot
O15524
canonical
ensembl
ENSG00000185338
resolver
ensp
ENSP00000329418
resolver
ensp
ENSP00000496577
resolver
ensp
ENSP00000528139
resolver
enst
ENST00000332029
resolver
enst
ENST00000644787
resolver
enst
ENST00000858080
resolver
genesymbol
SOCS1
resolver
genesymbol_syn
SSI1
resolver
genesymbol_syn
TIP3
resolver
hgnc
HGNC:19383
resolver
uniprot
O15097
resolver
uniprot
Q4JHT5
resolver
uniprot
Q9NSA7
resolver
uniprot_entry
Q4JHT5_HUMAN
resolver
uniprot_entry
SOCS1_HUMAN
resolver
uniprot_sec
O15097
resolver
uniprot_sec
Q9NSA7
resolver
amino_acid_sequence
MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI
uniprot
proteins
disease_involvement
DISEASE: Autoinflammatory syndrome, familial, with or without immunodeficiency (AISIMD) [MIM:619375]: An autosomal dominant, autoinflammatory disorder with incomplete penetrance characterized by autoimmune cytopenia, hemolytic anemia, thrombocytopenia, and lymphadenopathy. Additional variable features may include autoimmune thyroiditis, psoriasis or eczema, nephritis, hepatitis, and symptoms of systemic lupus erythematosus. Immunodeficiency is present in some patients. Disease onset is usually in the first decades of life, although later onset has been reported. {ECO:0000269|PubMed:32499645, ECO:0000269|PubMed:32853638, ECO:0000269|PubMed:33087723}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed:32499645, PubMed:33087723). Down-regulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed:9341160). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11278610, PubMed:11313480). {ECO:0000250|UniProtKB:O35716, ECO:0000269|PubMed:11278610, ECO:0000269|PubMed:11313480, ECO:0000269|PubMed:32499645, ECO:0000269|PubMed:33087723, ECO:0000269|PubMed:9341160}.
uniprot
proteins
mass_dalton
23551
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
SOCS1 family
uniprot
proteins
pubmed
10512686
uniprot
proteins
pubmed
11278610
uniprot
proteins
pubmed
11313480
uniprot
proteins
pubmed
11553846
uniprot
proteins
pubmed
11835308
uniprot
proteins
pubmed
12163497
uniprot
proteins
pubmed
12470648
uniprot
proteins
pubmed
16410555
uniprot
proteins
pubmed
23401859
uniprot
proteins
pubmed
32499645
uniprot
proteins
pubmed
32853638
uniprot
proteins
pubmed
33087723
uniprot
proteins
pubmed
9202125
uniprot
proteins
pubmed
9202126
uniprot
proteins
pubmed
9266833
uniprot
proteins
pubmed
9341160
uniprot
proteins
pubmed
9727029
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16410555}. Cytoplasmic vesicle {ECO:0000269|PubMed:16410555}. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
uniprot
proteins