Nfatc4
entrez
73181
canonical
uniprot
Q8K120
canonical
ensembl
ENSMUSG00000023411
resolver
ensp
ENSMUSP00000024179
resolver
ensp
ENSMUSP00000132763
resolver
genesymbol
Nfatc4
resolver
genesymbol_syn
Nfat3
resolver
uniprot
B5B2X2
resolver
uniprot
Q3TXW7
resolver
uniprot
Q9EP91
resolver
uniprot_entry
NFAC4_MOUSE
resolver
uniprot_sec
B5B2X2
resolver
uniprot_sec
Q3TXW7
resolver
uniprot_sec
Q9EP91
resolver
amino_acid_sequence
MGAASCEDEELEFKLVFGEEKEPPPLGPGGPGEELDSEDTPPCCRLALGEPLPYGAAPIGIPRPPPPRPGMHSPPPRPAPSPGTWESQPARSVRLGGPGGNAGGAGGGRVLECPSIRITSISPTPDPPTSLEDTSETWGDGSPRDYPPPEGFGGYREAGGQGGGAFFSPSPGSSSLSSWSFFSDASDEAALYAACDEVESELNEAASRFGLSSPLPSPRASPRPWTPEDPWSLYGPSSGGRAPEDSWLLLSAPGPVPASPRPASPCGKRRYSSSGTPSSASPALSRRGSLGEEGPEPPPPPPLPLVRDPSSPGPFDYVGAPPTESIPQKTRRTSSEQAVALPRSEEPPSCNGKLPSGTEDSVAAPGALRKEVAGMDYLAVPSPLAWSKARIGGHSPIFRTSALPPLDWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHPVVKLLGYSEKPLTLQMFIGTADERSLRPHAFYQVHRITGKMVATASYEAVVSGTKVLEMTLLPENNMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGGGKVVSVQAASVPIECSQRSAQELPQVETYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGPDGKLQWEEEAAVNRLQSSEVTLTLTIPEYSNKRVSRPVQVYFYVSNGRRKRSPTQSFKFLPVVFKEEPLPDSSLRGFPSTSGPPFGPDVDFSPPRPPYPSYPHEDPAYETPYLSEGFGYSTPALYPQTGPPPSYRSGLRMFPETGGTTGCARLPSVSFLPRPFPGDQYGGQGSSFALGLPFSPPAPFRPPLPSSPPLEDPFHPQSAIHPLPPEGYNEVGPGYTPGEGASEQEKARGGYSSGFRDSVPIQGITLEEVSEIIGRDLSGFPARPGEEPPA
uniprot
proteins
function
FUNCTION: Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:17198697). Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (PubMed:19538478). Along with NFATC3, involved in embryonic heart development (PubMed:12750314, PubMed:17198697). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (PubMed:12750314). Transactivates many genes involved in heart physiology. Along with GATA4, binds to and activates NPPB/BNP promoter (PubMed:9568714). Activates NPPA/ANP/ANF and MYH7/beta-MHC transcription (By similarity). Binds to and transactivates AGTR2 gene promoter (PubMed:17198697). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (PubMed:22586092). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during a developmental critical period when auditory neurons depend on afferent input for survival (PubMed:18354019). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP). Plays a role in adipocyte differentiation. May be involved in myoblast differentiation into myotubes (By similarity). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription. Binds to PPARG gene promoter and regulates its activity (By similarity). Binds to PPARG and REG3G gene promoters (PubMed:17198697). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q14934, ECO:0000269|PubMed:12750314, ECO:0000269|PubMed:17198697, ECO:0000269|PubMed:18354019, ECO:0000269|PubMed:19538478, ECO:0000269|PubMed:22586092, ECO:0000269|PubMed:9568714, ECO:0000305|PubMed:9568714}.
uniprot
proteins
mass_dalton
95782
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NFATC-kinases; dephosphorylated by calcineurin/PPP3CA. Phosphorylated on Ser-168 and Ser-170 by MTOR, IRAK1, MAPK7/ERK5 and MAPK14/p38, on Ser-213 and Ser-217 by MAPK8 and MAPK9, and on Ser-289 and Ser-344 by RPS6KA3 (PubMed:18691762). Phosphorylated by GSK3B (By similarity). Phosphorylation by GSK3B markedly increases NFATC4 ubiquitination (By similarity). Phosphorylation by MAPK8/JNK1, MAPK9/JNK2 and RPS6KA3 may stimulate NFATC4 transcriptional activity. Phosphorylation at Ser-168 and Ser-170 is stimulated by UV irradiation (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q14934, ECO:0000269|PubMed:18691762}.; PTM: Ubiquitinated, leading to degradation by the proteasome. Ubiquitination may be stimulated by GSK3B-dependent phosphorylation. Polyubiquitin linkage mainly occurs through 'Lys-48'. {ECO:0000250|UniProtKB:Q14934}.
uniprot
proteins
pubmed
11344309
uniprot
proteins
pubmed
12370307
uniprot
proteins
pubmed
12750314
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17198697
uniprot
proteins
pubmed
17579027
uniprot
proteins
pubmed
18354019
uniprot
proteins
pubmed
18675896
uniprot
proteins
pubmed
18691762
uniprot
proteins
pubmed
19538478
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21435446
uniprot
proteins
pubmed
22586092
uniprot
proteins
pubmed
24970700
uniprot
proteins
pubmed
25215946
uniprot
proteins
pubmed
25663301
uniprot
proteins
pubmed
9568714
uniprot
proteins
sequence_length
901
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18354019, ECO:0000269|PubMed:22586092, ECO:0000269|PubMed:24970700}. Nucleus {ECO:0000269|PubMed:18354019, ECO:0000269|PubMed:22586092, ECO:0000269|PubMed:24970700, ECO:0000269|PubMed:25215946}. Note=When hyperphosphorylated, localizes in the cytosol. When intracellular Ca(2+) levels increase, dephosphorylation by calcineurin/PPP3CA leads to translocation into the nucleus (By similarity). MAPK7/ERK5 and MTOR regulate NFATC4 nuclear export through phosphorylation at Ser-168 and Ser-170 (By similarity). {ECO:0000250|UniProtKB:Q14934}.
uniprot
proteins