STBD1
entrez
8987
canonical
uniprot
O95210
canonical
ensembl
ENSG00000118804
resolver
ensp
ENSP00000237642
resolver
enst
ENST00000237642
resolver
genesymbol
STBD1
resolver
hgnc
HGNC:24854
resolver
uniprot
B3KVZ9
resolver
uniprot_entry
STBD1_HUMAN
resolver
uniprot_sec
B3KVZ9
resolver
amino_acid_sequence
MGAVWSALLVGGGLAGALFVWLLRGGPGDTGKDGDAEQEKDAPLGGAAIPGGHQSGSSGLSPGPSGQELVTKPEHLQESNGHLISKTKDLGKLQAASWRLQNPSREVCDNSREHVPSGQFPDTEAPATSETSNSRSYSEVSRNESLESPMGEWGFQKGQEISAKAATCFAEKLPSSNLLKNRAKEEMSLSDLNSQDRVDHEEWEMVPRHSSWGDVGVGGSLKAPVLNLNQGMDNGRSTLVEARGQQVHGKMERVAVMPAGSQQVSVRFQVHYVTSTDVQFIAVTGDHECLGRWNTYIPLHYNKDGFWSHSIFLPADTVVEWKFVLVENGGVTRWEECSNRFLETGHEDKVVHAWWGIH
uniprot
proteins
function
FUNCTION: Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}.
uniprot
proteins
mass_dalton
39007
uniprot
proteins
mutagenesis
MUTAGEN 203; /note="W->A: Abolishes interaction with GABARAPL1."; /evidence="ECO:0000269|PubMed:21893048"; MUTAGEN 206; /note="V->A: Abolishes interaction with GABARAPL1."; /evidence="ECO:0000269|PubMed:21893048"; MUTAGEN 293; /note="W->G,L: Abolishes GYS2- and glycogen-binding, and leads to rapid degradation."; /evidence="ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:24837458
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, which leads to proteasomal degradation. {ECO:0000269|PubMed:24837458}.
uniprot
proteins
pubmed
12424126
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20810658
uniprot
proteins
pubmed
21893048
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24837458
uniprot
proteins
pubmed
9794794
uniprot
proteins
sequence_length
358
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Preautophagosomal structure membrane {ECO:0000269|PubMed:20810658, ECO:0000305|PubMed:21893048}; Single-pass type III membrane protein {ECO:0000305|PubMed:9794794}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24837458}; Single-pass type III membrane protein {ECO:0000305|PubMed:9794794}. Cell membrane, sarcolemma, T-tubule {ECO:0000269|PubMed:9794794}. Note=Also detected near the junctional sarcoplasmic reticulum (PubMed:9794794). Concentrates at perinuclear structures (PubMed:21893048). {ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:9794794}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..23; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins