Aebp2
entrez
11569
canonical
uniprot
Q9Z248
canonical
ensembl
ENSMUSG00000030232
resolver
ensp
ENSMUSP00000032359
resolver
ensp
ENSMUSP00000084896
resolver
ensp
ENSMUSP00000092993
resolver
ensp
ENSMUSP00000123897
resolver
ensp
ENSMUSP00000124148
resolver
ensp
ENSMUSP00000125479
resolver
ensp
ENSMUSP00000259024
resolver
genesymbol
Aebp2
resolver
uniprot
Q6PF91
resolver
uniprot
Q78HB0
resolver
uniprot
Q8BGV1
resolver
uniprot
Q8CE51
resolver
uniprot_entry
AEBP2_MOUSE
resolver
uniprot_sec
Q6PF91
resolver
uniprot_sec
Q78HB0
resolver
uniprot_sec
Q8BGV1
resolver
uniprot_sec
Q8CE51
resolver
amino_acid_sequence
MAAALADMADLEELSRLSPLSPGSPGPAARGRAEPPEEEEEEDDEEAEAEAVAALLLNGGAGGGAGGGEAETMSEPSPESASQAGGDEDEDEEDDEDEGSSSGGAEEESSAESLVGSSSGGCSGDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGGPGGPGSSGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTLMDIDSTISSGRSTPAMMNGQGSTTASSKHIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEESGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRFDILNFPR
uniprot
proteins
function
FUNCTION: Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene. Plays a role in nucleosome localization of the PRC2 complex. {ECO:0000269|PubMed:20144788, ECO:0000305|PubMed:10329662}.
uniprot
proteins
mass_dalton
52963
uniprot
proteins
mutagenesis
MUTAGEN 315..316; /note="HS->R: Abrogates transcriptional repression but does not affect DNA-binding."; /evidence="ECO:0000269|PubMed:10329662
uniprot
proteins
protein_family
AEBP2/jing C2H2-type zinc-finger family
uniprot
proteins
pubmed
10329662
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19026780
uniprot
proteins
pubmed
20144788
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
504
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6ZN18}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000250|UniProtKB:Q6ZN18}.
uniprot
proteins