Birc3
entrez
11796
canonical
uniprot
O08863
canonical
ensembl
ENSMUSG00000032000
resolver
ensp
ENSMUSP00000013949
resolver
ensp
ENSMUSP00000306978
resolver
enst
ENSMUST00000013949
resolver
genesymbol
Birc3
resolver
uniprot
A2CGA5
resolver
uniprot
E9QLX3
resolver
uniprot
Q3TSE5
resolver
uniprot_entry
A2CGA5_MOUSE
resolver
uniprot_entry
BIRC3_MOUSE
resolver
uniprot_entry
Q3TSE5_MOUSE
resolver
uniprot_sec
E9QLX3
resolver
activity_regulation
ACTIVITY REGULATION: USP19 regulates the stability of BIRC3/c-IAP2 by preventing its ubiquitination. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MVQDSAFLAKLMKSADTFELKYDFSCELYRLSTYSAFPRGVPVSERSLARAGFYYTGANDKVKCFCCGLMLDNWKQGDSPMEKHRKLYPSCNFVQTLNPANSLEASPRPSLPSTAMSTMPLSFASSENTGYFSGSYSSFPSDPVNFRANQDCPALSTSPYHFAMNTEKARLLTYETWPLSFLSPAKLAKAGFYYIGPGDRVACFACDGKLSNWERKDDAMSEHQRHFPSCPFLKDLGQSASRYTVSNLSMQTHAARIRTFSNWPSSALVHSQELASAGFYYTGHSDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEYLLRIKGQEFVSQVQAGYPHLLEQLLSTSDSPEDENADAAIVHFGPGESSEDVVMMSTPVVKAALEMGFSRSLVRQTVQWQILATGENYRTVSDLVIGLLDAEDEMREEQMEQAAEEEESDDLALIRKNKMVLFQHLTCVTPMLYCLLSARAITEQECNAVKQKPHTLQASTLIDTVLAKGNTAATSFRNSLREIDPALYRDIFVQQDIRSLPTDDIAALPMEEQLRKLQEERMCKVCMDREVSIVFIPCGHLVVCKDCAPSLRKCPICRGTIKGTVRTFLS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. {ECO:0000269|PubMed:18621737}.
uniprot
proteins
mass_dalton
67228
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated and degraded by the proteasome in apoptotic cells. {ECO:0000250}.
uniprot
proteins
protein_family
IAP family
uniprot
proteins
pubmed
18621737
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9441758
uniprot
proteins
sequence_length
600
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins