TMEM86B
entrez
255043
canonical
uniprot
Q8N661
canonical
ensembl
ENSG00000180089
resolver
ensp
ENSP00000321038
resolver
enst
ENST00000327042
resolver
genesymbol
TMEM86B
resolver
hgnc
HGNC:28448
resolver
uniprot_entry
TM86B_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Competitively inhibited by lysophosphatidic acid. {ECO:0000269|PubMed:21515882}.
uniprot
proteins
amino_acid_sequence
MDAGKAGQTLKTHCSAQRPDVCRWLSPFILSCCVYFCLWIPEDQLSWFAALVKCLPVLCLAGFLWVMSPSGGYTQLLQGALVCSAVGDACLIWPAAFVPGMAAFATAHLLYVWAFGFSPLQPGLLLLIILAPGPYLSLVLQHLEPDMVLPVAAYGLILMAMLWRGLAQGGSAGWGALLFTLSDGVLAWDTFAQPLPHAHLVIMTTYYAAQLLITLSALRSPVPKTD
uniprot
proteins
ec_number
3.3.2.2
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of plasmalogen. {ECO:0000269|PubMed:21515882}.
uniprot
proteins
mass_dalton
24352
uniprot
proteins
protein_family
TMEM86 family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21515882
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D8N3}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:21515882}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..40; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 76..93; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 101..117; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 124..140; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 147..163; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..188; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 200..218; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins