Dgkq
entrez
110524
canonical
uniprot
Q6P5E8
canonical
ensembl
ENSMUSG00000004815
resolver
ensp
ENSMUSP00000057859
resolver
ensp
ENSMUSP00000279887
resolver
ensp
ENSMUSP00000279901
resolver
ensp
ENSMUSP00000279924
resolver
genesymbol
Dgkq
resolver
uniprot
Q3UYE8
resolver
uniprot_entry
DGKQ_MOUSE
resolver
uniprot_sec
Q3UYE8
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphatidylserine. {ECO:0000250|UniProtKB:P52824}.
uniprot
proteins
amino_acid_sequence
MAAAAEPGARTWPGSGSPRLGSPAGSPVLGISGRTRPGSGPERTSRAIGSAAPGHSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLKQVKTPCTSIAPSLVRVPVAHCFGSLGLYKRKFCVVCRKSLEVPAFRCEVCELHVHPDCVPFACSDCRQCHQDGQQDYDTYHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSVCSTALAPECTFGRLRSMVLPPSCVRLLSRNFSKMHCFRIPETMVLELGDGDDGVDGSAAIGTGREVLTATESTKQTLKIFDGNDSMRKNQFRLVTVSRLARNEEVMEAALRAYYISEDPKDFQLQALPLSGNAQALGKAGTTEEEASKGSCPRDSVPEAWVIRSLPRTQEILKIYPGWLKVGVAYVSIRVNSQSTARSVVQEVLPLFGQQVEDKERFQLIEVLMSSRQVQRTVLADEEPLLDRLWDIRQTSVRQVSQTRFYVAETRATAPRVSLFVGGLPPGLSPQDYSNLLHEAMATKAAVVSVSHVYSLQGAVILDVTCFAEAERLYMLARDTAVHGRPLTALVLPDVLHTKLPPDCCPLLVFVNPKSGGLKGRELLCSFRKLLNPHQVFELTNGGPLPGFHLFSQVPSFRVLVCGGDGTVGWVLAALEETRRHLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLVSVDEADAVLMDRWTILLDAHEIDSTENNVVETEPPKIVQMNNYCGIGIDAELSLDFHQAREEEPGKFTSRFHNKGVYVRVGLQKISHSRSLHKEIRLQVEQQEVELPSIEGLIFINIPSWGSGADLWGSDNDSRFEKPRIDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGHMIISATAPKVHMLRKAKQKPRKAGANRDTRVDTLPAPEGNPL
uniprot
proteins
ec_number
2.7.1.107
uniprot
proteins
ec_number
2.7.1.93
uniprot
proteins
function
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:26748701). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (By similarity). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701). {ECO:0000250|UniProtKB:D3ZEY4, ECO:0000250|UniProtKB:P52824, ECO:0000269|PubMed:26748701}.
uniprot
proteins
mass_dalton
102254
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000269|PubMed:26748701}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKCE and PRKCH in vitro. {ECO:0000250|UniProtKB:P52824}.
uniprot
proteins
protein_family
Eukaryotic diacylglycerol kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26748701
uniprot
proteins
sequence_length
934
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P52824}. Cytoplasm, cytosol {ECO:0000269|PubMed:26748701}. Cell membrane {ECO:0000250|UniProtKB:P52824}. Synapse {ECO:0000269|PubMed:26748701}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P52824}. Nucleus {ECO:0000250|UniProtKB:P52824}. Nucleus speckle {ECO:0000250|UniProtKB:P52824}. Nucleus matrix {ECO:0000250|UniProtKB:D3ZEY4}. Note=Translocates to the plasma membrane in response to steroid hormone receptor stimulation. Translocation to the plasma membrane is dependent on G protein-coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH. Translocates to the nucleus in response to thrombin stimulation (By similarity). Association with the nuclear matrix is regulated by nerve growth factor (By similarity). {ECO:0000250|UniProtKB:D3ZEY4, ECO:0000250|UniProtKB:P52824}.
uniprot
proteins