RPS6KB2
entrez
6199
canonical
uniprot
Q9UBS0
canonical
ensembl
ENSG00000175634
resolver
ensp
ENSP00000308413
resolver
ensp
ENSP00000675099
resolver
ensp
ENSP00000742253
resolver
genesymbol
RPS6KB2
resolver
genesymbol_syn
STK14B
resolver
hgnc
HGNC:10437
resolver
uniprot
B2RMZ9
resolver
uniprot
B4DML8
resolver
uniprot
O94809
resolver
uniprot
Q9UEC1
resolver
uniprot_entry
KS6B2_HUMAN
resolver
uniprot_sec
B2RMZ9
resolver
uniprot_sec
B4DML8
resolver
uniprot_sec
O94809
resolver
uniprot_sec
Q9UEC1
resolver
amino_acid_sequence
MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRAPVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRPGR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193). {ECO:0000269|PubMed:29750193}.
uniprot
proteins
mass_dalton
53455
uniprot
proteins
post_translational_modification
PTM: Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention. {ECO:0000269|PubMed:12087098, ECO:0000269|PubMed:12529391}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
S6 kinase subfamily
uniprot
proteins
pubmed
10490847
uniprot
proteins
pubmed
12087098
uniprot
proteins
pubmed
12529391
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29750193
uniprot
proteins
pubmed
9804755
uniprot
proteins
pubmed
9878560
uniprot
proteins
sequence_length
482
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
uniprot
proteins