Fam162a
entrez
70186
canonical
uniprot
Q9D6U8
canonical
ensembl
ENSMUSG00000003955
resolver
ensp
ENSMUSP00000004057
resolver
enst
ENSMUST00000004057
resolver
genesymbol
Fam162a
resolver
genesymbol_syn
E2ig5
resolver
uniprot_entry
F162A_MOUSE
resolver
amino_acid_sequence
MWSLGGLRLAAGHCLRLYERNASSSLRFTRNTDLKRINGFCTKPQESPKTPTQSYRHGVPLHKPTDFEKKILLWSGRFKKEEEIPETISFEMLDAAKNKLRVKVSYLMIALTVAGCIYMVIEGKKAAKRHESLTSLNLERKARLREEAAMKAKTD
uniprot
proteins
function
FUNCTION: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (PubMed:17316997). {ECO:0000269|PubMed:15082785, ECO:0000269|PubMed:17316997}.
uniprot
proteins
mass_dalton
17725
uniprot
proteins
protein_family
UPF0389 family
uniprot
proteins
pubmed
15082785
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17316997
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
155
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250|UniProtKB:Q96A26}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 104..121; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins