Ang4
entrez
219033
canonical
uniprot
Q3TMQ6
canonical
ensembl
ENSMUSG00000060615
resolver
ensp
ENSMUSP00000073525
resolver
enst
ENSMUST00000073860
resolver
genesymbol
Ang4
resolver
uniprot
Q3UWE7
resolver
uniprot
Q80XS4
resolver
uniprot
Q80Z85
resolver
uniprot_entry
ANG4_MOUSE
resolver
uniprot_sec
Q3UWE7
resolver
uniprot_sec
Q80XS4
resolver
uniprot_sec
Q80Z85
resolver
amino_acid_sequence
MTMSPCPLLLVFVLGLVVIPPTLAQNERYEKFLRQHYDAKPNGRDDRYCESMMKERKLTSPCKDVNTFIHGTKKNIRAICGKKGSPYGENFRISNSPFQITTCTHSGASPRPPCGYRAFKDFRYIVIACEDGWPVHFDESFISP
uniprot
proteins
ec_number
3.1.27.-
uniprot
proteins
function
FUNCTION: Has bactericidal activity against E.faecalis and L.monocytogenes, but not against L.innocua and E.coli. Promotes angiogenesis (in vitro). Has low ribonuclease activity (in vitro). Promotes proliferation of melanoma cells, but not of endothelial cells or fibroblasts (in vitro). {ECO:0000269|PubMed:12548285, ECO:0000269|PubMed:17279775}.
uniprot
proteins
mass_dalton
16425
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="H->A: Loss of ribonuclease activity. Loss of angiogenic activity."; /evidence="ECO:0000269|PubMed:17279775"; MUTAGEN 56; /note="R->A: Loss of angiogenic activity. No effect on ribonuclease activity."; /evidence="ECO:0000269|PubMed:17279775"; MUTAGEN 83; /note="K->N: Loss of angiogenic activity. No effect on ribonuclease activity."; /evidence="ECO:0000269|PubMed:17279775"; MUTAGEN 136; /note="H->A: Loss of ribonuclease activity. Loss of angiogenic activity."; /evidence="ECO:0000269|PubMed:17279775"; MUTAGEN 139; /note="E->A: Loss of angiogenic activity. Increased ribonuclease activity."; /evidence="ECO:0000269|PubMed:17279775
uniprot
proteins
protein_family
Pancreatic ribonuclease family
uniprot
proteins
pubmed
12548285
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17279775
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
144
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12548285}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000269|PubMed:12548285}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P03950}. Note=Exposure to bacterial lipopolysaccharide (LPS) triggers secretion from intestinal epithelium cells (PubMed:12548285). Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity). {ECO:0000250|UniProtKB:P03950, ECO:0000269|PubMed:12548285}.
uniprot
proteins