Clspn
entrez
269582
canonical
uniprot
Q80YR7
canonical
ensembl
ENSMUSG00000042489
resolver
ensp
ENSMUSP00000045344
resolver
ensp
ENSMUSP00000339340
resolver
enst
ENSMUST00000048391
resolver
genesymbol
Clspn
resolver
uniprot
B1ARX6
resolver
uniprot
Q69GM2
resolver
uniprot_entry
CLSPN_MOUSE
resolver
uniprot_sec
B1ARX6
resolver
uniprot_sec
Q69GM2
resolver
amino_acid_sequence
MTGEVGSEVNLEVNDLKLLSQEAADSPVDSGQGSFETLEPLSERDSDEEIFVSKKPKSRKVLQDSDSEAEDRDDAPEKPTYDDSAEDTQENLHSGKSQSRSFPKALADSDESDMEETPSQESPETQEAPSLEPGHQTGHSVDFTTGRKLSKTLLREGAEGKAKSKRRLEKEERTMEKIRRLKKKETRCEESDADRPLNDSGCLLEDSDLFETGLEEENDSALEDEESLESIRAAVKNKVKNRKKKEPTLESEAFSLEDGNELSKGSARKERKAARLSKEALKKLHSETQRLVRESALNLPYHMPESKTIHDFFKRKPRPTCQGSAMALLKSCKYQSGHYKETVNPADAAGMGAEDSSRGSEQRTGAGIAAETNVLSEVSEEAGITAGSDEACGKDPVRRGELEIEETEKHSDDRPYSPGDRSMSQQESSIPRIEDNEGHQAGDLTESDPPALEGEELKTVEKTDAKEGMPEQKTQSAAAAAVAVVTAAAAPPEKVRRFTVDRLRQLGVDVSSQPRLGADEDSFVILDEPKTNRELEALKQRFWRHANPAASPRACQTVNVNIIVKDLGTNGKEELKAEVVPVTLAAEKLEGASHAKPGEKLQMLKAKLQEAMKLRRLEERQKRQALFKLDNEDGFEEEEEEEEMTDESEEDGEEETTEYLLGSEDTETKDEKETDKENTDTSSDIGKSVALCVPKPLSSDSTLLLFKDSSSKMGYFPTEEKSETDEYLAKQSDKLDEDDSSSLLTKESSHNSSFELIGSTIPSYQPCNRQIGRGASFLPTAGFRSPSPGLFRGSLISSASKSSGKLSEPSLPVEDSQDLYTASPEPKTLFLGAGDFQFCLEDDTQSQLLDADGFLNIRNHRHRYQAVKPQLPLASMDENAMDANMDELLDLCTGQFTSQPEEKCQPRKNDKKENMEELLNLCSGKFPTQDASPVAPLGLRSQEKESSTEDPMEEALALCSGSFPTDREEEGEEEEFGDFQLVSKENGFASDEDEHSDSNDEELALDLEDDEEELLKQSEKMKRQMRLKKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELESQIKKIHMKTMLDDDKRRLRLYQERYLADGDLHSDGPGRTRKFRWKHIDDTSQMDLFHRDSDDDQVEEQLDETEAKWRKERIEREQWLREQAQQGKIAADEEDIGDDSQFMMLAKKVTAKALQKNASHTVVVQESKSVLRNPFETIRPGGAHQLKTGSLLNQPKAVLQKLAALSDLNPSAPRNSRNFVFHTLSPTKAEAAKDSSKPQVRRRGLSSMMSPSPKRLKTNGSSPGPKRSIFRYLES
uniprot
proteins
function
FUNCTION: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:27401717). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (By similarity). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication (PubMed:27401717). Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS. Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (By similarity). {ECO:0000250|UniProtKB:Q9HAW4, ECO:0000269|PubMed:27401717}.
uniprot
proteins
mass_dalton
146715
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Undergoes ATR-dependent phosphorylation by CHEK1 during activation of DNA replication or damage checkpoints. Phosphorylation by CSNK1G1/CK1 promotes CHEK1 binding. Phosphorylated by CDC7 during DNA replication, phosphorylation inhibits interaction between the acidic patch and N-terminal segments leading to increased binding to DNA and PCNA. {ECO:0000250|UniProtKB:Q9HAW4}.; PTM: Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) during G1 phase, leading to its degradation by the proteasome. Ubiquitination is mediated via its interaction with FZR1/CDH1. Following DNA damage, it is deubiquitinated by USP28 in G2 phase, preventing its degradation (By similarity). {ECO:0000250|UniProtKB:Q9HAW4}.; PTM: Proteolytically cleaved by caspase-7 (CASP7) in response to apoptosis, leading to its inactivation. {ECO:0000250|UniProtKB:Q9HAW4}.
uniprot
proteins
protein_family
Claspin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27401717
uniprot
proteins
sequence_length
1315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9HAW4}.
uniprot
proteins