Atp1a1
entrez
11928
canonical
uniprot
Q8VDN2
canonical
ensembl
ENSMUSG00000033161
resolver
ensp
ENSMUSP00000039657
resolver
enst
ENSMUST00000036493
resolver
genesymbol
Atp1a1
resolver
uniprot
Q91Z09
resolver
uniprot_entry
AT1A1_MOUSE
resolver
uniprot_sec
Q91Z09
resolver
amino_acid_sequence
MGKGVGRDKYEPAAVSEHGDKKGKKAKKERDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTPARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIRSATEEEPPNDDLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEDVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAEEIEHFIHLITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWFALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIEVCCGSVMEMREKYSKIVEIPFNSTNKYQLSIHKNPNASEPKHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLLLPDEQFPEGFQFDTDDVNFPVDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVNQVNPRDAKACVVHGSDLKDMTSEELDDILRYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIVGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPFHLLGIRETWDDRWVNDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGAALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY
uniprot
proteins
ec_number
7.2.2.13
uniprot
proteins
function
FUNCTION: Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (By similarity). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (PubMed:17408578). {ECO:0000250|UniProtKB:P05023, ECO:0000269|PubMed:17408578}.
uniprot
proteins
mass_dalton
112982
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIC subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15743908
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17283221
uniprot
proteins
pubmed
17408578
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
1023
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17408578}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P05023}. Basolateral cell membrane {ECO:0000250|UniProtKB:P06685}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P05023}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P05023}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P05023}. Cell projection, axon {ECO:0000250|UniProtKB:P06685}. Melanosome {ECO:0000250|UniProtKB:P05023}.
uniprot
proteins
transmembrane_region
TRANSMEM 92..116; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 291..312; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 319..342; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 773..795; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 804..822; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 845..870; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 918..938; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 952..970; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 985..1008; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023, ECO:0000255
uniprot
proteins