Elovl1
entrez
54325
canonical
uniprot
Q9JLJ5
canonical
ensembl
ENSMUSG00000006390
resolver
ensp
ENSMUSP00000006557
resolver
ensp
ENSMUSP00000064816
resolver
ensp
ENSMUSP00000099734
resolver
ensp
ENSMUSP00000126685
resolver
ensp
ENSMUSP00000243420
resolver
ensp
ENSMUSP00000243422
resolver
enst
ENSMUST00000006557
resolver
enst
ENSMUST00000067896
resolver
enst
ENSMUST00000102673
resolver
enst
ENSMUST00000167636
resolver
genesymbol
Elovl1
resolver
genesymbol_syn
ELOVL1
resolver
genesymbol_syn
Ssc1
resolver
uniprot
F6RWE2
resolver
uniprot
Q4V9V3
resolver
uniprot
Q548M4
resolver
uniprot
Q9D1B2
resolver
uniprot_entry
ELOV1_MOUSE
resolver
uniprot_entry
F6RWE2_MOUSE
resolver
uniprot_entry
Q4V9V3_MOUSE
resolver
uniprot_entry
Q548M4_MOUSE
resolver
uniprot_sec
Q9D1B2
resolver
amino_acid_sequence
MEAVVNLYHELMKHADPRIQSYPLMGSPLLITSILLTYVYFILSLGPRIMANRKPFQLRGFMIVYNFSLVILSLYIVYEFLMSGWLSTYTWRCDPIDFSNSPEALRMVRVAWLFMLSKVIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGIKIAPGGMGSFHAMINSSVHVVMYLYYGLSALGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMPSCNYQYPIIIHLIWMYGTIFFILFSNFWYHSYTKGKRLPRAVQQNGAPATTKVKAN
uniprot
proteins
ec_number
2.3.1.199
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. {ECO:0000255|HAMAP-Rule:MF_03201, ECO:0000269|PubMed:10791983, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:23407971, ECO:0000269|PubMed:23689133}.
uniprot
proteins
mass_dalton
32678
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03201, ECO:0000269|PubMed:20937905}.
uniprot
proteins
protein_family
ELO family
uniprot
proteins
protein_family
ELOVL1 subfamily
uniprot
proteins
pubmed
10791983
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20937905
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23407971
uniprot
proteins
pubmed
23689133
uniprot
proteins
sequence_length
279
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03201}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03201}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03201"; TRANSMEM 61..81; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03201"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03201"; TRANSMEM 137..154; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03201"; TRANSMEM 176..196; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03201"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03201"; TRANSMEM 231..251; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03201
uniprot
proteins