P29321
uniprot
P29321
canonical
amino_acid_sequence
RIHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLREAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTILQLVGMLKGVGAGMRYLSDLGYIHRDLAARNILVDGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNQDVISSVEEGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFSHVVSVLEALVHSPESLRATATVSRCPAPAFARSCFDLRAGGNGNGDLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLHMNAQDVRALGITLMGHQKKILGSIQTMRSQLSCTQGPRRHL
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
41233
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation is stimulated upon binding of its ligands including EFNA2, EFNA3 and EFNA5. Autophosphorylation on Tyr-206 modulates tyrosine kinase activity (By similarity). {ECO:0000250}.; PTM: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
1648701
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O09127}; Single-pass type I membrane protein {ECO:0000255}. Cell projection {ECO:0000250|UniProtKB:O09127}. Early endosome membrane {ECO:0000250|UniProtKB:O09127}. Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes. {ECO:0000250|UniProtKB:O09127}.
uniprot
proteins