RAB9B
entrez
51209
canonical
uniprot
Q9NP90
canonical
ensembl
ENSG00000123570
resolver
ensp
ENSP00000243298
resolver
ensp
ENSP00000543795
resolver
ensp
ENSP00000633333
resolver
ensp
ENSP00000633334
resolver
enst
ENST00000243298
resolver
enst
ENST00000873736
resolver
enst
ENST00000963274
resolver
enst
ENST00000963275
resolver
genesymbol
RAB9B
resolver
genesymbol_syn
RAB9L
resolver
hgnc
HGNC:14090
resolver
uniprot
B2R8M0
resolver
uniprot
Q52LX2
resolver
uniprot_entry
RAB9B_HUMAN
resolver
uniprot_sec
B2R8M0
resolver
uniprot_sec
Q52LX2
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MSGKSLLLKVILLGDGGVGKSSLMNRYVTNKFDSQAFHTIGVEFLNRDLEVDGRFVTLQIWDTAGQERFKSLRTPFYRGADCCLLTFSVDDRQSFENLGNWQKEFIYYADVKDPEHFPFVVLGNKVDKEDRQVTTEEAQTWCMENGDYPYLETSAKDDTNVTVAFEEAVRQVLAVEEQLEHCMLGHTIDLNSGSKAGSSCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB9B is involved in the transport of proteins between the endosomes and the trans Golgi network (By similarity). May use NDE1/NDEL1 as an effector to interact with the dynein motor complex in order to control retrograde trafficking of RAB9-associated late endosomes to the TGN (PubMed:34793709). {ECO:0000250|UniProtKB:P51151, ECO:0000250|UniProtKB:P62820, ECO:0000269|PubMed:34793709}.
uniprot
proteins
mass_dalton
22719
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11043518
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
20048159
uniprot
proteins
pubmed
21255211
uniprot
proteins
pubmed
22637480
uniprot
proteins
pubmed
34793709
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
uniprot
proteins