Tnfaip8l2
entrez
69769
canonical
uniprot
Q9D8Y7
canonical
ensembl
ENSMUSG00000013707
resolver
ensp
ENSMUSP00000013851
resolver
ensp
ENSMUSP00000171221
resolver
enst
ENSMUST00000013851
resolver
genesymbol
Tnfaip8l2
resolver
uniprot_entry
TP8L2_MOUSE
resolver
amino_acid_sequence
MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPKAQRVIKDLIKVAVKVAVLHRSGCFGPGELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLLVECRDILLELVEHHLTPKSHDRIRHVFDHYSDPDLLAALYGPDFTQHLGKICDGLRKLLDEGKL
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression (PubMed:18455983). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Also inhibits autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (PubMed:34524845). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (PubMed:34524845). {ECO:0000250|UniProtKB:Q6P589, ECO:0000269|PubMed:18455983, ECO:0000269|PubMed:34524845}.
uniprot
proteins
mass_dalton
20615
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by TAK1/MAP3K7; this phosphorylation triggers association with BTRC and subsequent ubiquitination and degradation. {ECO:0000250|UniProtKB:Q6P589}.; PTM: Ubiquitinated in a BTRC-depdent manner; leading to degradation mediated through the proteasome pathway. {ECO:0000250|UniProtKB:Q6P589}.
uniprot
proteins
protein_family
TNFAIP8 family
uniprot
proteins
protein_family
TNFAIP8L2 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18455983
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34524845
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6P589}. Nucleus {ECO:0000250|UniProtKB:Q6P589}. Lysosome {ECO:0000250|UniProtKB:Q6P589}.
uniprot
proteins