Eif3k
entrez
73830
canonical
uniprot
Q9DBZ5
canonical
ensembl
ENSMUSG00000053565
resolver
ensp
ENSMUSP00000066038
resolver
ensp
ENSMUSP00000146940
resolver
ensp
ENSMUSP00000147214
resolver
enst
ENSMUST00000208616
resolver
genesymbol
Eif3k
resolver
genesymbol_syn
EIF3K
resolver
genesymbol_syn
EIF3S12
resolver
genesymbol_syn
Eif3s12
resolver
uniprot
A0A140LJH4
resolver
uniprot
Q3TY56
resolver
uniprot
Q58EU9
resolver
uniprot
Q8K3A1
resolver
uniprot_entry
A0A140LJH4_MOUSE
resolver
uniprot_entry
EIF3K_MOUSE
resolver
uniprot_entry
Q3TY56_MOUSE
resolver
uniprot_sec
Q58EU9
resolver
uniprot_sec
Q8K3A1
resolver
amino_acid_sequence
MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLTDNQLKVWMSKYGWSADESGQVFICSQEESIKPKNIVEKIDFDSVSSIMASSQ
uniprot
proteins
function
FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000255|HAMAP-Rule:MF_03010, ECO:0000269|PubMed:17581632}.
uniprot
proteins
mass_dalton
25087
uniprot
proteins
protein_family
EIF-3 subunit K family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17581632
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03010}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03010}.
uniprot
proteins