KDM2A
entrez
22992
canonical
uniprot
Q9Y2K7
canonical
ensembl
ENSG00000173120
resolver
ensp
ENSP00000309302
resolver
ensp
ENSP00000432786
resolver
ensp
ENSP00000435776
resolver
enst
ENST00000308783
resolver
genesymbol
KDM2A
resolver
genesymbol_syn
CXXC8
resolver
genesymbol_syn
FBL11
resolver
genesymbol_syn
FBL7
resolver
genesymbol_syn
FBXL11
resolver
genesymbol_syn
JHDM1A
resolver
genesymbol_syn
KIAA1004
resolver
hgnc
HGNC:13606
resolver
uniprot
A0A0A0MR24
resolver
uniprot
D4QA03
resolver
uniprot
E9PIL6
resolver
uniprot
I3VM53
resolver
uniprot
I3VM54
resolver
uniprot
I3VM55
resolver
uniprot
Q49A21
resolver
uniprot
Q4G0M3
resolver
uniprot
Q69YY8
resolver
uniprot
Q9BVH5
resolver
uniprot
Q9H7H5
resolver
uniprot
Q9UK66
resolver
uniprot_entry
A0A0A0MR24_HUMAN
resolver
uniprot_entry
I3VM53_HUMAN
resolver
uniprot_entry
I3VM54_HUMAN
resolver
uniprot_entry
KDM2A_HUMAN
resolver
uniprot_sec
D4QA03
resolver
uniprot_sec
E9PIL6
resolver
uniprot_sec
I3VM55
resolver
uniprot_sec
Q49A21
resolver
uniprot_sec
Q4G0M3
resolver
uniprot_sec
Q69YY8
resolver
uniprot_sec
Q9BVH5
resolver
uniprot_sec
Q9H7H5
resolver
uniprot_sec
Q9UK66
resolver
amino_acid_sequence
MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHFISDLSINSLYCLSDEKLIQKIS
uniprot
proteins
ec_number
1.14.11.27
uniprot
proteins
function
FUNCTION: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}.
uniprot
proteins
mass_dalton
132793
uniprot
proteins
mutagenesis
MUTAGEN 212..214; /note="HVD->AVA: Abolishes lysine-specific histone demethylase activity."; /evidence="ECO:0000269|PubMed:28262558"; MUTAGEN 212; /note="H->A: Abolishes histone demethylase activity. No loss of its ability to repress the transcriptional activator activity of the CLOCK-BMAL1 heterodimer."; /evidence="ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:26037310"; MUTAGEN 571; /note="C->A: Abolishes association with centromeric heterochromatin; when associated with A-574 and A-577."; /evidence="ECO:0000269|PubMed:19001877"; MUTAGEN 574; /note="C->A: Abolishes association with centromeric heterochromatin; when associated with A-571 and A-577. Loss of its ability to repress the transcriptional activator activity of the CLOCK-BMAL1 heterodimer; when associated with A-577."; /evidence="ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310"; MUTAGEN 577; /note="C->A: Abolishes association with centromeric heterochromatin; when associated with A-571 and A-574. Loss of its ability to repress the transcriptional activator activity of the CLOCK-BMAL1 heterodimer; when associated with A-574."; /evidence="ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310"; MUTAGEN 620; /note="C->A: No loss of its ability to repress the transcriptional activator activity of the CLOCK-BMAL1 heterodimer; when associated with A-623."; /evidence="ECO:0000269|PubMed:26037310"; MUTAGEN 623; /note="C->A: No loss of its ability to repress the transcriptional activator activity of the CLOCK-BMAL1 heterodimer; when associated with A-620."; /evidence="ECO:0000269|PubMed:26037310"; MUTAGEN 892; /note="W->V: Reduced interaction with UBB."; /evidence="ECO:0000269|PubMed:30033217
uniprot
proteins
post_translational_modification
PTM: Mono-ADP-ribosylated at Arg-1020 in response to DNA damage, leading to displacement from chromatin, resulting in increased dimethylation of histone H3 at 'Lys-36'. {ECO:0000250|UniProtKB:P59997}.
uniprot
proteins
protein_family
JHDM1 histone demethylase family
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
10945468
uniprot
proteins
pubmed
11214971
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16362057
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19001877
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20417597
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26037310
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28262558
uniprot
proteins
pubmed
30033217
uniprot
proteins
sequence_length
1162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:20417597}. Chromosome {ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:20417597}. Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region (PubMed:19001877, PubMed:20417597). Specifically nucleates at CpG islands where its presence results in chromatin depleted in H3K36me2 (PubMed:19001877, PubMed:20417597). {ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:20417597}.
uniprot
proteins