Ciao1
entrez
29231
canonical
uniprot
Q5M7T1
canonical
ensembl
ENSRNOG00000012638
resolver
ensembl
ENSRNOG00055005334
resolver
ensembl
ENSRNOG00060014702
resolver
ensembl
ENSRNOG00065012925
resolver
ensp
ENSRNOP00000017603
resolver
ensp
ENSRNOP00000089224
resolver
ensp
ENSRNOP00055006525
resolver
ensp
ENSRNOP00060020108
resolver
ensp
ENSRNOP00065016338
resolver
enst
ENSRNOT00000017603
resolver
enst
ENSRNOT00000113397
resolver
enst
ENSRNOT00055008619
resolver
enst
ENSRNOT00060025234
resolver
enst
ENSRNOT00065021174
resolver
genesymbol
Ciao1
resolver
genesymbol_syn
Wdr39
resolver
uniprot
A0A8I6A7Q2
resolver
uniprot_entry
A0A8I6A7Q2_RAT
resolver
uniprot_entry
CIAO1_RAT
resolver
amino_acid_sequence
MKDALVLQSRVPAHPDSRCWFLAWNPTGTLLASCGGDRKIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYQEEGDDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCVCTLSGFHTRTIYDVAWCQLTGALATACGDDAIRVFEEDPGSDPQQPTFSLTAHLRQAHSQDVNCVAWNPKEAGLLASCSDDGEVAFWEYHQPAGL
uniprot
proteins
function
FUNCTION: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (By similarity). Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity). {ECO:0000250|UniProtKB:O76071, ECO:0000255|HAMAP-Rule:MF_03037}.
uniprot
proteins
mass_dalton
37618
uniprot
proteins
protein_family
WD repeat CIA1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O76071}.
uniprot
proteins