Faah
entrez
100911581
canonical
uniprot
P97612
canonical
ensembl
ENSRNOG00000045949
resolver
ensembl
ENSRNOG00055031772
resolver
ensembl
ENSRNOG00060027493
resolver
ensembl
ENSRNOG00065016061
resolver
ensp
ENSRNOP00000015667
resolver
ensp
ENSRNOP00055045429
resolver
ensp
ENSRNOP00060039713
resolver
ensp
ENSRNOP00065020953
resolver
enst
ENSRNOT00000015667
resolver
enst
ENSRNOT00055054982
resolver
enst
ENSRNOT00060047749
resolver
enst
ENSRNOT00065026704
resolver
genesymbol
Faah
resolver
genesymbol_syn
Faah1
resolver
uniprot
Q5BKA3
resolver
uniprot_entry
FAAH1_RAT
resolver
uniprot_sec
Q5BKA3
resolver
activity_regulation
ACTIVITY REGULATION: inhibited by trifluoromethyl ketone. {ECO:0000269|PubMed:9122178}.
uniprot
proteins
amino_acid_sequence
MVLSEVWTTLSGVSGVCLACSLLSAAVVLRWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQPS
uniprot
proteins
ec_number
3.1.1.-
uniprot
proteins
ec_number
3.5.1.99
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:10526230, PubMed:11128635, PubMed:15533037, PubMed:17649977, PubMed:9122178, PubMed:9299394, PubMed:9790682). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:11128635, PubMed:9122178). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:10526230, PubMed:15533037, PubMed:17649977). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity). {ECO:0000250|UniProtKB:O08914, ECO:0000269|PubMed:10526230, ECO:0000269|PubMed:11128635, ECO:0000269|PubMed:15533037, ECO:0000269|PubMed:17649977, ECO:0000269|PubMed:9122178, ECO:0000269|PubMed:9299394, ECO:0000269|PubMed:9790682}.
uniprot
proteins
mass_dalton
63357
uniprot
proteins
mutagenesis
MUTAGEN 142; /note="K->A: Lowers activity 40000-fold. Lowers activity 70000-fold; when associated with A-217."; /evidence="ECO:0000269|PubMed:12734197"; MUTAGEN 217; /note="S->A: Lowers activity 3000-fold. Lowers activity 70000-fold; when associated with A-142."; /evidence="ECO:0000269|PubMed:12734197
uniprot
proteins
protein_family
Amidase family
uniprot
proteins
pubmed
10526230
uniprot
proteins
pubmed
11128635
uniprot
proteins
pubmed
12459591
uniprot
proteins
pubmed
12734197
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15533037
uniprot
proteins
pubmed
17649977
uniprot
proteins
pubmed
18753625
uniprot
proteins
pubmed
8900284
uniprot
proteins
pubmed
9122178
uniprot
proteins
pubmed
9299394
uniprot
proteins
pubmed
9452020
uniprot
proteins
pubmed
9790682
uniprot
proteins
sequence_length
579
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9122178, ECO:0000269|PubMed:9790682}; Single-pass membrane protein {ECO:0000269|PubMed:9122178}. Golgi apparatus membrane {ECO:0000269|PubMed:9122178, ECO:0000269|PubMed:9790682}; Single-pass membrane protein {ECO:0000269|PubMed:9122178}. Note=Seems to be associated with the endoplasmic reticulum and/or Golgi apparatus.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins