Amh
entrez
11705
canonical
uniprot
P27106
canonical
ensembl
ENSMUSG00000035262
resolver
ensp
ENSMUSP00000043153
resolver
enst
ENSMUST00000036016
resolver
genesymbol
Amh
resolver
uniprot
A0A8Q0P8A2
resolver
uniprot
A7E2R1
resolver
uniprot
Q5EC55
resolver
uniprot_entry
A0A8Q0P8A2_MOUSE
resolver
uniprot_entry
AMH_MOUSE
resolver
uniprot_sec
A7E2R1
resolver
uniprot_sec
Q5EC55
resolver
amino_acid_sequence
MQGPHLSPLVLLLATMGAVLQPEAVENLATNTRGLIFLEDELWPPSSPPEPLCLVTVRGEGNTSRASLRVVGGLNSYEYAFLEAVQESRWGPQDLATFGVCSTDSQATLPALQRLGAWLGETGEQQLLVLHLAEVIWEPELLLKFQEPPPGGASRWEQALLVLYPGPGPQVTVTGTGLRGTQNLCPTRDTRYLVLTVDFPAGAWSGSGLILTLQPSREGATLSIDQLQAFLFGSDSRCFTRMTPTLVVLPPAEPSPQPAHGQLDTMPFPQPGLSLEPEALPHSADPFLETLTRLVRALRGPLTQASNTQLALDPGALASFPQGLVNLSDPAALGRLLDWEEPLLLLLSPAAATEREPMPLHGPASAPWAAGLQRRVAVELQAAASELRDLPGLPPTAPPLLARLLALCPNDSRSSGDPLRALLLLKALQGLRAEWHGREGRGRTGRSAGTGTDGPCALRELSVDLRAERSVLIPETYQANNCQGACAWPQSDRNPRYGNHVVLLLKMQARGAALGRLPCCVPTAYAGKLLISLSEERISAHHVPNMVATECGCV
uniprot
proteins
function
FUNCTION: The anti-Muellerian hormone (AMH) plays an important role in several reproductive functions (PubMed:11606457, PubMed:11861535, PubMed:1782869, PubMed:9435237). Anti-Muellerian hormone binds and activates AMHR2, its specific type-II receptor, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A) to regulate target gene expression through downstream SMAD protein signal transduction (By similarity). Produced and secreted by Sertoli cells of the male fetus, anti-Muellerian hormone induces Muellerian duct regression during male fetal sexual differentiation (PubMed:1782869, PubMed:9435237). In female, it is produced by granulosa cells of the preantral and small antral follicles and acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (PubMed:11606457, PubMed:11861535). Also plays a role in Leydig cell differentiation and function (PubMed:1782869, PubMed:9435237). {ECO:0000250|UniProtKB:P03971, ECO:0000269|PubMed:11606457, ECO:0000269|PubMed:11861535, ECO:0000269|PubMed:1782869, ECO:0000269|PubMed:9435237}.; FUNCTION: Plays an important role in several reproductive functions, including Muellerian duct regression during male fetal sexua,l differentiation and in the adult plays a role in Leydig cell differentiation and function (PubMed:1782869, PubMed:9435237). In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (PubMed:11606457, PubMed:11861535). Binds to its sole type II receptor, AMHR2 that recruits type I receptors ACVR1 and BMPR1A which subsequently activates the Smad pathway (By similarity). {ECO:0000250|UniProtKB:P03971, ECO:0000269|PubMed:11606457, ECO:0000269|PubMed:11861535, ECO:0000269|PubMed:1782869, ECO:0000269|PubMed:9435237}.
uniprot
proteins
mass_dalton
59244
uniprot
proteins
post_translational_modification
PTM: The preproprotein is proteolytically processed to generate the AMH prodomain and the anti-Muellerian hormone (By similarity). Both homodimerize covalently, and homodimers associate to form a non-covalent heterotetrameric complex (By similarity). {ECO:0000250|UniProtKB:P03971}.
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
11606457
uniprot
proteins
pubmed
11861535
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1782869
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7954809
uniprot
proteins
pubmed
8541848
uniprot
proteins
pubmed
9435237
uniprot
proteins
sequence_length
554
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P03971}.
uniprot
proteins