FNDC5
entrez
252995
canonical
uniprot
Q8NAU1
canonical
ensembl
ENSG00000160097
resolver
ensp
ENSP00000362570
resolver
ensp
ENSP00000476320
resolver
enst
ENST00000373471
resolver
genesymbol
FNDC5
resolver
genesymbol_syn
FRCP2
resolver
hgnc
HGNC:20240
resolver
uniprot
A0A0A0MRR6
resolver
uniprot
A0AA34QVI5
resolver
uniprot
A6NMC9
resolver
uniprot
D3DPQ6
resolver
uniprot
Q6P6D9
resolver
uniprot
Q7Z676
resolver
uniprot_entry
A0A0A0MRR6_HUMAN
resolver
uniprot_entry
FNDC5_HUMAN
resolver
uniprot_sec
A0AA34QVI5
resolver
uniprot_sec
A6NMC9
resolver
uniprot_sec
D3DPQ6
resolver
uniprot_sec
Q6P6D9
resolver
uniprot_sec
Q7Z676
resolver
amino_acid_sequence
MQAARGGAGRPERPGRPGRGPERERERPPGAGAASPCAAPGLPAGGATIHPGSPSAWPPRARAALRLWLGCVCFALVQADSPSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQGQSPASEPVLFKTPREAEKMASKNKDEVTMKEMGRNQQLRTGEVLIIVVVLFMWAGVIALFCRQYDIIKDNEPNNNKEKTKSASETSTPEHQGGGLLRSKI
uniprot
proteins
function
FUNCTION: [Irisin]: Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. {ECO:0000250|UniProtKB:Q8K4Z2}.
uniprot
proteins
mass_dalton
28283
uniprot
proteins
mutagenesis
MUTAGEN 126; /note="R->E: Abolishes dimerization; probably prevents inter-subunit salt bridge formation."; /evidence="ECO:0000269|PubMed:24114836
uniprot
proteins
post_translational_modification
PTM: The extracellular domain is cleaved and released from the cell membrane. {ECO:0000250|UniProtKB:Q8K4Z2}.; PTM: N-Glycosylated. {ECO:0000250|UniProtKB:Q8K4Z2}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
22237023
uniprot
proteins
pubmed
24040023
uniprot
proteins
pubmed
24114836
uniprot
proteins
pubmed
26278051
uniprot
proteins
pubmed
38471509
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Fibronectin type III domain-containing protein 5]: Cell membrane {ECO:0000269|PubMed:22237023}; Single-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000250|UniProtKB:Q8K4Z2}; Single-pass membrane protein {ECO:0000255}. Note=Imported into peroxisomes through the PEX5 receptor pathway. {ECO:0000250|UniProtKB:Q8K4Z2}.; SUBCELLULAR LOCATION: [Irisin]: Secreted {ECO:0000269|PubMed:22237023}. Note=Detected in plasma following endurance exercise. {ECO:0000269|PubMed:22237023}.
uniprot
proteins
transmembrane_region
TRANSMEM 201..221; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins