S1pr1
entrez
29733
canonical
uniprot
P48303
canonical
ensembl
ENSRNOG00000013683
resolver
ensembl
ENSRNOG00055001051
resolver
ensembl
ENSRNOG00060000950
resolver
ensembl
ENSRNOG00065022778
resolver
ensp
ENSRNOP00000052627
resolver
ensp
ENSRNOP00000098635
resolver
ensp
ENSRNOP00000100933
resolver
ensp
ENSRNOP00000101281
resolver
ensp
ENSRNOP00000107206
resolver
ensp
ENSRNOP00000108446
resolver
ensp
ENSRNOP00055001361
resolver
ensp
ENSRNOP00060000541
resolver
ensp
ENSRNOP00065031535
resolver
enst
ENSRNOT00000018318
resolver
enst
ENSRNOT00000125679
resolver
enst
ENSRNOT00000140136
resolver
enst
ENSRNOT00000142036
resolver
enst
ENSRNOT00000144764
resolver
enst
ENSRNOT00000172725
resolver
enst
ENSRNOT00055001746
resolver
enst
ENSRNOT00060001259
resolver
enst
ENSRNOT00065038878
resolver
genesymbol
S1pr1
resolver
genesymbol_syn
Edg1
resolver
uniprot
Q4V7F6
resolver
uniprot_entry
S1PR1_RAT
resolver
uniprot_sec
Q4V7F6
resolver
amino_acid_sequence
MVSSTSIPVVKALRSQVSDYGNYDIIVRHYNYTGKLNIGVEKDHGIKLTSVVFILICCLIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCISSLSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKTCDILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIISCCKCPNGDSAGKFKRPIIPGMEFSRSKSDNSSHPQKDDGDNPETIMSSGNVNSSS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury (By similarity). {ECO:0000250|UniProtKB:P21453}.
uniprot
proteins
mass_dalton
42746
uniprot
proteins
post_translational_modification
PTM: Palmitoylated by ZDHHC5. Palmitoylation is required for targeting to plasma membrane, enabling G(i) coupling. {ECO:0000250|UniProtKB:P21453}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7959012
uniprot
proteins
sequence_length
383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P21453}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P21453}. Endosome {ECO:0000250|UniProtKB:P21453}. Membrane raft {ECO:0000250|UniProtKB:P21453}. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization. {ECO:0000250|UniProtKB:P21453}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..69; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 84..105; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 118..139; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 162..183; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 198..225; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 259..279; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 291..311; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins