Naa50
entrez
72117
canonical
uniprot
Q6PGB6
canonical
ensembl
ENSMUSG00000022698
resolver
ensp
ENSMUSP00000070140
resolver
ensp
ENSMUSP00000124291
resolver
ensp
ENSMUSP00000125517
resolver
genesymbol
Naa50
resolver
genesymbol_syn
Mak3
resolver
genesymbol_syn
Nat13
resolver
uniprot
Q3TH79
resolver
uniprot
Q3TK59
resolver
uniprot
Q7TML2
resolver
uniprot
Q80VE3
resolver
uniprot
Q9D0Q8
resolver
uniprot_entry
NAA50_MOUSE
resolver
uniprot_sec
Q3TH79
resolver
uniprot_sec
Q3TK59
resolver
uniprot_sec
Q7TML2
resolver
uniprot_sec
Q80VE3
resolver
uniprot_sec
Q9D0Q8
resolver
amino_acid_sequence
MKGSRIELGDVTPHNIKQLKRLNQVIFPVSYNDKFYKDVLEVGELAKLAYFNDIAVGAVCCRVDHSQNQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEKDGTFDNIYLHVQISNESAIDFYRKFGFEIIETKKNYYKRIEPADAHVLQKNLKVPSGQNAETQKTDN
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.258
uniprot
proteins
function
FUNCTION: N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (By similarity). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (By similarity). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (By similarity). Autoacetylates in vivo (By similarity). The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo (By similarity). Component of N-alpha-acetyltransferase complexes containing NAA10 and NAA15, which has N-alpha-acetyltransferase activity (By similarity). Does not influence the acetyltransferase activity of NAA10 (By similarity). However, it negatively regulates the N-alpha-acetyltransferase activity of the N-terminal acetyltransferase A complex (also called the NatA complex) (By similarity). The multiprotein complexes probably constitute the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides (By similarity). Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 (By similarity). {ECO:0000250|UniProtKB:Q9GZZ1}.
uniprot
proteins
mass_dalton
19414
uniprot
proteins
protein_family
Acetyltransferase family
uniprot
proteins
protein_family
GNAT subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16484612
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
169
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16484612}. Nucleus {ECO:0000250|UniProtKB:Q9GZZ1}. Note=Localizes to the cytoplasm in interphase cells. {ECO:0000250|UniProtKB:Q9GZZ1}.
uniprot
proteins