Appl1
entrez
72993
canonical
uniprot
Q8K3H0
canonical
ensembl
ENSMUSG00000040760
resolver
ensp
ENSMUSP00000042875
resolver
enst
ENSMUST00000036570
resolver
genesymbol
Appl1
resolver
genesymbol_syn
Dip13a
resolver
genesymbol_syn
Kiaa1428
resolver
uniprot
Q3UJP7
resolver
uniprot
Q69ZJ9
resolver
uniprot
Q8BWZ8
resolver
uniprot
Q8VCJ8
resolver
uniprot
Q9CUW4
resolver
uniprot_entry
DP13A_MOUSE
resolver
uniprot_sec
Q3UJP7
resolver
uniprot_sec
Q69ZJ9
resolver
uniprot_sec
Q8BWZ8
resolver
uniprot_sec
Q8VCJ8
resolver
uniprot_sec
Q9CUW4
resolver
amino_acid_sequence
MPGIDKLPIEETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLTSKLLKEYEKQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPISQFKERDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNGQLEEFLANIGTSVQNVRREMDGDVETMQQTIEDLEVASDPLYLPDPDPTKFPINRNLTRKAGYLNARNKTGLVSSTWDRQFYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTINNISKQIYLSENPEETAARVNQSALEAVTPSPSFQQRHESLRPGGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPVCEDQPGQAKAFGQGGRRTNPFGESGGSTKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLVTCDCLKLIDPQTQVTRLTFPLPCVVLYATHQENKRLFGFVLRTSGGRSESNLSSVCYIFESNNEGEKICDSVGLAKQIALHAELDRRASEKQKEIERVKEKQQKELSKQKQIEKDLEEQSRLIAASSRPNQAGSEGQLVLSSSQSEESDLGEEGKKRESEA
uniprot
proteins
function
FUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (By similarity) (PubMed:25328665, PubMed:25568335, PubMed:27219021). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (By similarity). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (PubMed:25328665). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (PubMed:25568335). Regulates TLR4 signaling in activated macrophages (PubMed:27219021). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner. Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (By similarity). Required for fibroblast migration through HGF cell signaling (PubMed:26445298). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (By similarity). {ECO:0000250|UniProtKB:Q9UKG1, ECO:0000269|PubMed:25328665, ECO:0000269|PubMed:25568335, ECO:0000269|PubMed:26445298, ECO:0000269|PubMed:27219021}.
uniprot
proteins
mass_dalton
79328
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-410 by PKA severely impairs binding to OCRL. {ECO:0000250|UniProtKB:Q9UKG1}.
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19661063
uniprot
proteins
pubmed
20133602
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21849472
uniprot
proteins
pubmed
25328665
uniprot
proteins
pubmed
25568335
uniprot
proteins
pubmed
26445298
uniprot
proteins
pubmed
27219021
uniprot
proteins
sequence_length
707
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:21849472}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UKG1}. Nucleus {ECO:0000250|UniProtKB:Q9UKG1}. Cytoplasm {ECO:0000250|UniProtKB:Q9UKG1}. Endosome {ECO:0000269|PubMed:25568335, ECO:0000269|PubMed:27219021}. Cell projection, ruffle {ECO:0000269|PubMed:25568335}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:25568335}. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF. {ECO:0000250|UniProtKB:Q9UKG1}.
uniprot
proteins