DCAF17
entrez
80067
canonical
uniprot
Q5H9S7
canonical
ensembl
ENSG00000115827
resolver
ensp
ENSP00000364404
resolver
ensp
ENSP00000442238
resolver
ensp
ENSP00000477604
resolver
ensp
ENSP00000577694
resolver
ensp
ENSP00000577695
resolver
ensp
ENSP00000587851
resolver
ensp
ENSP00000587853
resolver
ensp
ENSP00000796499
resolver
enst
ENST00000539783
resolver
enst
ENST00000611110
resolver
genesymbol
DCAF17
resolver
genesymbol_syn
C2orf37
resolver
hgnc
HGNC:25784
resolver
uniprot
B2RTW5
resolver
uniprot
F5H7W1
resolver
uniprot
Q53TN3
resolver
uniprot
Q9H908
resolver
uniprot_entry
DCA17_HUMAN
resolver
uniprot_entry
F5H7W1_HUMAN
resolver
uniprot_sec
B2RTW5
resolver
uniprot_sec
Q53TN3
resolver
uniprot_sec
Q9H908
resolver
amino_acid_sequence
MGPTRKPNVCSRLSRRALGCFSRDAGVVQRTNLGILRALVCQESTKFKNVWTTHSRSPIAYERGRIYFDNYRRCVSSVASEPRKLYEMPKCSKSEKIEDALLWECPVGDILPNSSDYKSSLIALTAHNWLLRISATTGKILEKIYLAPYCKFRYLSWDTPQEVIAVKSAQNRGSAVARQAGIQQHVLLYLAVFRVLPFSLVGILEINKKIFGNVTDATLSHGILIVMYSSGLVRLYSFQTIAEQFMQQKLDLGCACRWGGTTGTVGEAPFGIPCNIKITDMPPLLFEVSSLENAFQIGGHPWHYIVTPNKKKQKGVFHICALKDNSLAKNGIQEMDCCSLESDWIYFHPDASGRIIHVGPNQVKVLKLTEIENNSSQHQISEDFVILANRENHKNENVLTVTASGRVVKKSFNLLDDDPEQETFKIVDYEDELDLLSVVAVTQIDAEGKAHLDFHCNEYGTLLKSIPLVESWDVTYSHEVYFDRDLVLHIEQKPNRVFSCYVYQMICDTGEEEETINRSC
uniprot
proteins
disease_involvement
DISEASE: Woodhouse-Sakati syndrome (WDSKS) [MIM:241080]: A rare autosomal recessive disorder characterized by hypogonadism, alopecia, diabetes mellitus, intellectual disability, and extrapyramidal syndrome. {ECO:0000269|PubMed:19026396}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367}.
uniprot
proteins
mass_dalton
58778
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16949367
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19026396
uniprot
proteins
sequence_length
520
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Nucleus, nucleolus {ECO:0000269|PubMed:19026396}. Note=According to PubMed:19026396, it is a nucleolar protein, while sequence analysis programs clearly predict 2 transmembrane regions.
uniprot
proteins
transmembrane_region
TRANSMEM 186..206; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 222..242; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins