Fgf2
entrez
14173
canonical
uniprot
P15655
canonical
ensembl
ENSMUSG00000037225
resolver
ensp
ENSMUSP00000122227
resolver
ensp
ENSMUSP00000143094
resolver
ensp
ENSMUSP00000201121
resolver
enst
ENSMUST00000138563
resolver
enst
ENSMUST00000200585
resolver
genesymbol
Fgf2
resolver
genesymbol_syn
Fgf-2
resolver
genesymbol_syn
Fgf2a
resolver
uniprot
Q541T2
resolver
uniprot_entry
FGF2_MOUSE
resolver
uniprot_entry
Q541T2_MOUSE
resolver
amino_acid_sequence
MAASGITSLPALPEDGGAAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHVKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTEECFFFERLESNNYNTYRSRKYSSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
uniprot
proteins
function
FUNCTION: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Also acts as an integrin ligand which is required for FGF2 signaling (By similarity). Binds to integrin ITGAV:ITGB3 (By similarity). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (By similarity). Functions as a potent mitogen in vitro (By similarity). Can induce angiogenesis (By similarity). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (By similarity). {ECO:0000250|UniProtKB:P09038}.
uniprot
proteins
mass_dalton
17153
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-81 regulates FGF2 unconventional secretion. {ECO:0000250}.
uniprot
proteins
protein_family
Heparin-binding growth factors family
uniprot
proteins
pubmed
20851768
uniprot
proteins
pubmed
2318343
uniprot
proteins
pubmed
28323137
uniprot
proteins
pubmed
9178765
uniprot
proteins
sequence_length
154
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P09038}. Nucleus {ECO:0000250|UniProtKB:P09038}. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism (By similarity). Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (By similarity). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (By similarity). Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (By similarity). {ECO:0000250|UniProtKB:P09038}.
uniprot
proteins