HIC1
entrez
3090
canonical
uniprot
Q14526
canonical
ensembl
ENSG00000177374
resolver
ensp
ENSP00000314080
resolver
ensp
ENSP00000477858
resolver
genesymbol
HIC1
resolver
genesymbol_syn
ZBTB29
resolver
hgnc
HGNC:4909
resolver
uniprot
A0PJI1
resolver
uniprot
D3DTI4
resolver
uniprot_entry
A0PJI1_HUMAN
resolver
uniprot_entry
HIC1_HUMAN
resolver
uniprot_sec
D3DTI4
resolver
amino_acid_sequence
MTFPEADILLKSGECAGQTMLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQACYPSPVGPPPPPAAEPPSGPEAAVNTHCAELYASGPGPAAALCASERRCSPLCGLDLSKKSPPGSAAPERPLAERELPPRPDSPPSAGPAAYKEPPLALPSLPPLPFQKLEEAAPPSDPFRGGSGSPGPEPPGRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPSERCEERGGDAAVSPGGPPLGLAPPPRYPGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT
uniprot
proteins
function
FUNCTION: Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). {ECO:0000250|UniProtKB:Q9R1Y5, ECO:0000269|PubMed:12052894, ECO:0000269|PubMed:15231840, ECO:0000269|PubMed:16269335, ECO:0000269|PubMed:16690027, ECO:0000269|PubMed:16724116, ECO:0000269|PubMed:18347096, ECO:0000269|PubMed:19486893, ECO:0000269|PubMed:19525223, ECO:0000269|PubMed:20154726, ECO:0000269|PubMed:20547755}.
uniprot
proteins
mass_dalton
76508
uniprot
proteins
mutagenesis
MUTAGEN 244; /note="L->A: Abolishes interaction with CTBP1 and CTBP2. Impairs transcriptional repression."; /evidence="ECO:0000269|PubMed:16762039"; MUTAGEN 333; /note="K->Q: Mimicks acetylation. Impairs interaction with RBBP4 and MTA1 and no effect on interaction with CTBP2. Reduces transcriptional repression."; /evidence="ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:20547755"; MUTAGEN 333; /note="K->R: Abolishes sumoylation; impairs transcriptional repression activity."; /evidence="ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:20547755"; MUTAGEN 335; /note="E->A: Impairs transcriptional repression activity. Decreases interaction with MTA1."; /evidence="ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:20547755"; MUTAGEN 336; /note="P->A: Impairs K-333 acetylation; no effect on sumoylation. Decreases interaction with MTA1."; /evidence="ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:20547755"; MUTAGEN 540; /note="C->S: Abolishes repression activity."; /evidence="ECO:0000269|PubMed:15231840
uniprot
proteins
post_translational_modification
PTM: Acetylated on several residues, including Lys-333. Lys-333 is deacetylated by SIRT1. {ECO:0000269|PubMed:17283066}.; PTM: Sumoylated on Lys-333 by a PIAS family member, which enhances interaction with MTA1, positively regulates transcriptional repression activity and is enhanced by HDAC4. {ECO:0000269|PubMed:17283066}.
uniprot
proteins
protein_family
Hic subfamily
uniprot
proteins
protein_family
Krueppel C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
10611298
uniprot
proteins
pubmed
11554746
uniprot
proteins
pubmed
12052894
uniprot
proteins
pubmed
15231840
uniprot
proteins
pubmed
16269335
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16690027
uniprot
proteins
pubmed
16724116
uniprot
proteins
pubmed
16762039
uniprot
proteins
pubmed
17213307
uniprot
proteins
pubmed
17283066
uniprot
proteins
pubmed
18347096
uniprot
proteins
pubmed
19486893
uniprot
proteins
pubmed
19525223
uniprot
proteins
pubmed
20154726
uniprot
proteins
pubmed
20547755
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25646486
uniprot
proteins
pubmed
7585125
uniprot
proteins
sequence_length
733
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11554746}.
uniprot
proteins