Brdt
entrez
114642
canonical
uniprot
Q91Y44
canonical
ensembl
ENSMUSG00000029279
resolver
ensp
ENSMUSP00000031215
resolver
ensp
ENSMUSP00000108297
resolver
genesymbol
Brdt
resolver
genesymbol_syn
Fsrg3
resolver
uniprot
G3X8Z8
resolver
uniprot
Q59HJ4
resolver
uniprot
Q8BNZ8
resolver
uniprot_entry
BRDT_MOUSE
resolver
uniprot_entry
Q8BNZ8_MOUSE
resolver
uniprot_sec
G3X8Z8
resolver
uniprot_sec
Q59HJ4
resolver
amino_acid_sequence
MSLPSRQTAIVNPPPPEYINTKKSGRLTNQLQFLQRVVLKALWKHGFSWPFQQPVDAVKLKLPDYYTIIKTPMDLNTIKKRLENKYYEKASECIEDFNTMFSNCYLYNKTGDDIVVMAQALEKLFMQKLSQMPQEEQVVGGKERIKKDIQQKIAVSSAKEQIPSKAAENVFKRQEIPSGLPDISLSPLNMAQEAPPICDSQSLVQITKGVKRRADTTTPTTSIAKASSESPPTLRETKPVNMPVKENTVKNVLPDSQQQHKVLKTVKVTEQLKHCSEILKEMLAKKHLPYAWPFYNPVDADALGLHNYYDVVKNPMDLGTIKGKMDNQEYKDAYEFAADVRLMFMNCYKYNPPDHEVVAMARTLQDVFELHFAKIPDEPIESMHACHLTTNSAQALSRESSSEASSGDASSEDSEDERVQHLAKLQEQLNAVHQQLQVLSQVPLRKLKKKNEKSKRAPKRKKVNNRDENPRKKPKQMKQKEKAKINQPKKKKPLLKSEEEDNAKPMNYDEKRQLSLDINKLPGDKLGRIVHIIQSREPSLRNSNPDEIEIDFETLKASTLRELEKYVLACLRKRSLKPQAKKVVRSKEELHSEKKLELERRLLDVNNQLNCRKRQTKRPAKVEKPPPPPPPPPPPPPPPELASGSRLTDSSSSSGSGSGSSSSSSGSSSSSSSSGSASSSSDSSSSDSSDSEPEIFPKFTGVKQNDLPPKENIKQIQSSVQDITSAEAPLAQQSTAPCGAPGKHSQQMLGCQVTQHLQATENTASVQTQPLSGDCKRVLLGPPVVHTSAESLTVLEPECHAPAQKDIKIKNADSWKSLGKPVKASSVLKSSDELFNQFRKAAIEKEVKARTQEQMRKHLEHNAKDPKVSQENQREPGSGLTLESLSSKVQDKSLEEDQSEQQPPSEAQDVSKLWLLKDRNLAREKEQERRRREAMAGTIDMTLQSDIMTMFENNFD
uniprot
proteins
function
FUNCTION: Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed:12861021, PubMed:19794495, PubMed:22901802, PubMed:22922464). Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA (PubMed:22901802, PubMed:32726616). Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (PubMed:27105113). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids (PubMed:22570411). Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin (PubMed:22020252). {ECO:0000269|PubMed:12861021, ECO:0000269|PubMed:19794495, ECO:0000269|PubMed:22020252, ECO:0000269|PubMed:22570411, ECO:0000269|PubMed:22901802, ECO:0000269|PubMed:22922464, ECO:0000269|PubMed:27105113, ECO:0000269|PubMed:32726616}.
uniprot
proteins
mass_dalton
107255
uniprot
proteins
mutagenesis
MUTAGEN 50..51; /note="PF->AA: Abolishes interaction with histone H4 acetylated N-terminus; when associated with A-55."; /evidence="ECO:0000269|PubMed:12861021"; MUTAGEN 55; /note="V->A: Abolishes interaction with histone H4 acetylated N-terminus; when associated with 50-AA-51."; /evidence="ECO:0000269|PubMed:12861021"; MUTAGEN 293..294; /note="PF->AA: Abolishes interaction with histone H4 acetylated N-terminus; when associated with A-298."; /evidence="ECO:0000269|PubMed:12861021"; MUTAGEN 298; /note="V->A: Abolishes interaction with histone H4 acetylated N-terminus; when associated with 293-AA-294."; /evidence="ECO:0000269|PubMed:12861021
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated in a SPOP-dependent manner, leading to proteasomal degradation. {ECO:0000269|PubMed:32726616}.
uniprot
proteins
protein_family
BET family
uniprot
proteins
pubmed
12861021
uniprot
proteins
pubmed
15261828
uniprot
proteins
pubmed
17049203
uniprot
proteins
pubmed
17728347
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19794495
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22020252
uniprot
proteins
pubmed
22570411
uniprot
proteins
pubmed
22901802
uniprot
proteins
pubmed
22922464
uniprot
proteins
pubmed
27105113
uniprot
proteins
pubmed
32726616
uniprot
proteins
sequence_length
956
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17728347, ECO:0000269|PubMed:19794495, ECO:0000269|PubMed:22020252, ECO:0000269|PubMed:32726616}. Note=Detected on chromatin (PubMed:19794495). Excluded from the chromocenter. {ECO:0000269|PubMed:19794495, ECO:0000269|PubMed:22020252}.
uniprot
proteins