GADD45A
entrez
1647
canonical
uniprot
P24522
canonical
ensembl
ENSG00000116717
resolver
ensp
ENSP00000360024
resolver
ensp
ENSP00000360025
resolver
ensp
ENSP00000496875
resolver
enst
ENST00000650283
resolver
genesymbol
GADD45A
resolver
genesymbol_syn
DDIT1
resolver
genesymbol_syn
GADD45
resolver
hgnc
HGNC:4095
resolver
uniprot
A0A3B3IRQ2
resolver
uniprot
A5JUZ3
resolver
uniprot
Q5TCA7
resolver
uniprot
Q5TCA8
resolver
uniprot_entry
A0A3B3IRQ2_HUMAN
resolver
uniprot_entry
A5JUZ3_HUMAN
resolver
uniprot_entry
GA45A_HUMAN
resolver
uniprot_sec
Q5TCA7
resolver
uniprot_sec
Q5TCA8
resolver
amino_acid_sequence
MTLEEFSAGEQKTERMDKVGDALEEVLSKALSQRTITVGVYEAAKLLNVDPDNVVLCLLAADEDDDRDVALQIHFTLIQAFCCENDINILRVSNPGRLAELLLLETDAGPAASEGAEQPPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVINLPER
uniprot
proteins
function
FUNCTION: In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. {ECO:0000250}.
uniprot
proteins
mass_dalton
18336
uniprot
proteins
mutagenesis
MUTAGEN 77; /note="L->E: Abolishes dimerization."; /evidence="ECO:0000269|PubMed:20460379
uniprot
proteins
protein_family
GADD45 family
uniprot
proteins
pubmed
12716909
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421274
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1990262
uniprot
proteins
pubmed
20460379
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
7973727
uniprot
proteins
pubmed
8226988
uniprot
proteins
sequence_length
165
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7973727}.
uniprot
proteins