Pelo
entrez
105083
canonical
uniprot
Q80X73
canonical
ensembl
ENSMUSG00000042275
resolver
ensp
ENSMUSP00000104849
resolver
enst
ENSMUST00000109226
resolver
genesymbol
Pelo
resolver
uniprot
Q3TCN0
resolver
uniprot
Q6PG91
resolver
uniprot
Q91UZ2
resolver
uniprot_entry
PELO_MOUSE
resolver
uniprot_sec
Q3TCN0
resolver
uniprot_sec
Q6PG91
resolver
uniprot_sec
Q91UZ2
resolver
amino_acid_sequence
MKLVRKDIEKDNAGQVTLVPEEPEDMWHTFNLVQVGDSLRASTIRKVQTESSTGSVGSNRVRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSVVLERIEQACDPAWSADVAAVVMQEGLAHVCLVTPSMTLTRAKVEVNIPRKRKGNCSQHDRALERFYEQVVQAIQRHINFEVVKCVLVASPGFVREQFCDYMFQQAVKTDNKVLLENRSKFLQVHASSGHKYSLKEALCDPTVASRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKQVERANEALAIDTLLISDELFRHQDVATRSRYVRLVDSVKENAGTVRIFSSLHVSGEQLGQLTGVAAILRFPVPELSDQEDDSSSEED
uniprot
proteins
function
FUNCTION: Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy. {ECO:0000250|UniProtKB:Q9BRX2}.
uniprot
proteins
mass_dalton
43349
uniprot
proteins
protein_family
Eukaryotic release factor 1 family
uniprot
proteins
protein_family
Pelota subfamily
uniprot
proteins
pubmed
12438745
uniprot
proteins
pubmed
12556505
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25061210
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BRX2}.
uniprot
proteins