Abr
entrez
287537
canonical
uniprot
A0A0G2JTR4
canonical
ensembl
ENSRNOG00000056837
resolver
ensp
ENSRNOP00000068811
resolver
ensp
ENSRNOP00000071246
resolver
ensp
ENSRNOP00000085287
resolver
ensp
ENSRNOP00000085893
resolver
ensp
ENSRNOP00000090388
resolver
enst
ENSRNOT00000080703
resolver
enst
ENSRNOT00000084670
resolver
enst
ENSRNOT00000098977
resolver
enst
ENSRNOT00000105253
resolver
enst
ENSRNOT00000109843
resolver
genesymbol
Abr
resolver
uniprot
A0A0G2JZZ7
resolver
uniprot
A0A4X0W8E9
resolver
uniprot
A0A8I6A171
resolver
uniprot
A0A8I6A3Q6
resolver
uniprot
A0A8I6GI56
resolver
uniprot_entry
A0A0G2JZZ7_RAT
resolver
uniprot_entry
A0A4X0W8E9_RAT
resolver
uniprot_entry
A0A8I6A171_RAT
resolver
uniprot_entry
A0A8I6A3Q6_RAT
resolver
uniprot_entry
A0A8I6GI56_RAT
resolver
uniprot_entry
ABR_RAT
resolver
amino_acid_sequence
MEPLSHRGLPRLSWIDTLYSNFSYGAEDYDAEGHEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGESISPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEMSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKVKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTTEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVESKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCIEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV
uniprot
proteins
function
FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). {ECO:0000250|UniProtKB:Q12979, ECO:0000250|UniProtKB:Q5SSL4}.
uniprot
proteins
mass_dalton
97693
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
20962234
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
859
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q5SSL4}. Cell projection, axon {ECO:0000250|UniProtKB:Q5SSL4}. Synapse {ECO:0000269|PubMed:20962234}.
uniprot
proteins