Atp13a1
entrez
170759
canonical
uniprot
Q9EPE9
canonical
ensembl
ENSMUSG00000031862
resolver
ensp
ENSMUSP00000034326
resolver
enst
ENSMUST00000034326
resolver
genesymbol
Atp13a1
resolver
genesymbol_syn
Atp13a
resolver
uniprot
B2RS54
resolver
uniprot_entry
AT131_MOUSE
resolver
uniprot_sec
B2RS54
resolver
amino_acid_sequence
MAVVGNAVPCGARPGGARDNGSPQPGSRLRPGLAAGPALIANGDELVAAVWPYRRLALLRRLTVLPFAGLLYPAWLGAAASGCWGWGSSWTQIPEAALLALATICLAHALTVLSGHWSVHAHCALTCTPEYDPNKVTFVKVVPTPNNGSTELVALHRDKGEDGLEVLSFEFQKIKYSYDALEKKQFLPVAFPVGNAFSYYQSNRGFQEDSEIRAAEKKFGSNKAEMVVPDFSELFKERATAPFFVFQVFCVGLWCLDEYWYYSVFTLSMLVAFEASLVQQQMRNMSEIRKMGNKPHMIQVYRSRKWRPVASDDIVPGDIVSIGRSPQENLVPCDVLLLRGRCIVDEAMLTGESVPQMKEPIEDLSPDRVLDLQADARLHVIFGGTKVVQHIPPQKATSGLKPVDNGCVAFVLRTGFNTSQGRLLRTILFGVKRVTANNLETFIFILFLLVFAIAAAAYVWVEGTKDPSRNRYKLFLECTLILTSVVPPELPIELSLAVNTSLIALAKLYMYCTEPFRIPFAGKVEVCCFDKTGTLTSDSLVVRGVAGLRDGKEVTPVSSIPIETHRALASCHSLMQLDDGTLVGDPLEKAMLTAVDWTLTKDEKVFPRSIKTQGLKIHQRFHFASALKRMSVLASYEKLGSTDLCYIAAVKGAPETLHSMFSQCPPDYHHIHTEISREGARVLALGYKELGHLTHQQAREIKREALECSLKFVGFIVVSCPLKADSKAVIREIQNASHRVVMITGDNPLTACHVAQELHFIDKAHTLILHPPSEKGQPCEWRSIDSSIVLPLTLGSPKALALEHALCLTGDGLAHLQAVDPQQLLCLIPHVQVFARVAPKQKEFVITSLKELGYVTLMCGDGTNDVGALKHADVGVALLANAPERVVERRRRPRDSPVLSNSGPRVSRSTKQKSALLSPEEPPASHRDRLSQVLRDLEEESTPIVKLGDASIAAPFTSKLSSIQCICHVIKQGRCTLVTTLQMFKILALNALILAYSQSVLYLEGVKFSDFQATLQGLLLAGCFLFISRSKPLKTLSRERPLPNIFNLYTILTVMLQFSVHFLSLVYLYREAQARSPEKQEQFVDLYKEFEPSLVNSTVYIMAMAMQMATFAINYKGPPFMESLPENKPLVWSLAVSLLAIIGLLLGSSPDFNSQFGLVDIPVEFKLVIGQVLALDFCLALLADRVLQFFLGTPKLRVPS
uniprot
proteins
ec_number
7.4.2.-
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum. Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane. Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains. {ECO:0000250|UniProtKB:Q9HD20}.
uniprot
proteins
mass_dalton
132388
uniprot
proteins
mutagenesis
MUTAGEN 530; /note="D->N: Loss of ATPase activity."; /evidence="ECO:0000269|PubMed:29505581
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type V subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29505581
uniprot
proteins
sequence_length
1200
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29505581}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9HD20}.
uniprot
proteins
transmembrane_region
TRANSMEM 64..84; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 441..461; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 986..1006; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1008..1028; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1048..1068; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1093..1113; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1129..1149; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1163..1183; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins