Nudt5
entrez
53893
canonical
uniprot
Q9JKX6
canonical
ensembl
ENSMUSG00000025817
resolver
ensp
ENSMUSP00000026927
resolver
ensp
ENSMUSP00000117670
resolver
ensp
ENSMUSP00000176426
resolver
ensp
ENSMUSP00000176427
resolver
ensp
ENSMUSP00000176428
resolver
enst
ENSMUST00000026927
resolver
genesymbol
Nudt5
resolver
uniprot
A2ATT6
resolver
uniprot
Q99KM4
resolver
uniprot_entry
NUDT5_MOUSE
resolver
uniprot_sec
A2ATT6
resolver
uniprot_sec
Q99KM4
resolver
amino_acid_sequence
METRESTESSPGKHLVTSEELISEGKWVKFEKTTYMDPTGKTRTWETVKLTTRKGKSADAVSVIPVLQRTLHHECVILVKQFRPPMGSYCLEFPAGFIEDGESPEAAALRELEEETGYKGEVAECSPAVCMDPGLSNCTTHVVTVTINGDDAGNVRPKPKPGDGEFMEVISLPKNDLLTRLDALGAEQHLTVDAKVYAYGLALKHANSKPFEVPFLKF
uniprot
proteins
ec_number
2.7.7.96
uniprot
proteins
ec_number
3.6.1.13
uniprot
proteins
ec_number
3.6.1.58
uniprot
proteins
function
FUNCTION: Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (By similarity). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10722730). Can also hydrolyze other nucleotide sugars with low activity (PubMed:10722730). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate (By similarity). Nuclear ATP synthesis takes place when dephosphorylated at Thr-44 (By similarity). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). In vitro, it has decapping activity on 11-mer RNA capped with uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) by hydrolyzing the pyrophosphate bridge of the sugar cap (By similarity). Does not play a role in U8 snoRNA decapping (PubMed:21070968). Binds U8 snoRNA (PubMed:21070968). {ECO:0000250|UniProtKB:Q9UKK9, ECO:0000269|PubMed:10722730, ECO:0000269|PubMed:21070968}.
uniprot
proteins
mass_dalton
23984
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-44 is required for homodimer stability; dephosphorylation results in destabilization of the homodimer. Dephosphorylation at Thr-44 promotes the ATP-synthesis activity. {ECO:0000250|UniProtKB:Q9UKK9}.
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
10722730
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21070968
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UKK9}.
uniprot
proteins