Prdx3
entrez
11757
canonical
uniprot
P20108
canonical
ensembl
ENSMUSG00000024997
resolver
ensp
ENSMUSP00000025961
resolver
enst
ENSMUST00000025961
resolver
genesymbol
Prdx3
resolver
genesymbol_syn
Aop1
resolver
genesymbol_syn
Mer5
resolver
uniprot_entry
PRDX3_MOUSE
resolver
amino_acid_sequence
MAAAAGRLLWSSVARHASAISRSISASTVLRPVASRRTCLTDILWSASAQGKSAFSTSSSFHTPAVTQHAPYFKGTAVVNGEFKELSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNITLLSDITKQISRDYGVLLESAGIALRGLFIIDPNGVVKHLSVNDLPVGRSVEETLRLVKAFQFVETHGEVCPANWTPESPTIKPSPTASKEYFEKVHQ
uniprot
proteins
ec_number
1.11.1.24
uniprot
proteins
function
FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (By similarity). Required for the maintenance of physical strength (PubMed:27037278). {ECO:0000250|UniProtKB:P30048, ECO:0000269|PubMed:27037278}.
uniprot
proteins
mass_dalton
28127
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by LRRK2; phosphorylation reduces perodixase activity. {ECO:0000250|UniProtKB:P30048}.; PTM: The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond. {ECO:0000250|UniProtKB:P30048}.; PTM: S-palmitoylated. {ECO:0000269|PubMed:31740833}.
uniprot
proteins
protein_family
AhpC/Prx1 subfamily
uniprot
proteins
protein_family
Peroxiredoxin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
2583515
uniprot
proteins
pubmed
27037278
uniprot
proteins
pubmed
31740833
uniprot
proteins
pubmed
9497357
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:9497357}. Cytoplasm {ECO:0000250|UniProtKB:P30048}. Early endosome {ECO:0000250|UniProtKB:P30048}. Note=Localizes to early endosomes in a RPS6KC1-dependent manner. {ECO:0000250|UniProtKB:P30048}.
uniprot
proteins