Sparc
entrez
24791
canonical
uniprot
P16975
canonical
ensembl
ENSRNOG00000012840
resolver
ensp
ENSRNOP00000017486
resolver
genesymbol
Sparc
resolver
uniprot
O08953
resolver
uniprot
Q6GSZ4
resolver
uniprot_entry
SPRC_RAT
resolver
uniprot_sec
O08953
resolver
uniprot_sec
Q6GSZ4
resolver
amino_acid_sequence
MRAWIFFLLCLAGRALAAPQTEAAEEMVAEETVVEETGLPVGANPVQVEMGEFEEGAEETVEEVVAENPCQNHHCKHGKVCELDESNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIAPCLDSELTEFPLRMRDWLKNVLVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALEEWAGCFGIKEQDINKDLVI
uniprot
proteins
function
FUNCTION: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
uniprot
proteins
mass_dalton
34296
uniprot
proteins
protein_family
SPARC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2322281
uniprot
proteins
pubmed
8660135
uniprot
proteins
pubmed
9541258
uniprot
proteins
sequence_length
301
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:2322281}. Note=In or around the basement membrane. {ECO:0000250}.
uniprot
proteins