Polk
entrez
27015
canonical
uniprot
Q9QUG2
canonical
ensembl
ENSMUSG00000021668
resolver
ensp
ENSMUSP00000022172
resolver
ensp
ENSMUSP00000088950
resolver
ensp
ENSMUSP00000152178
resolver
ensp
ENSMUSP00000152192
resolver
ensp
ENSMUSP00000152647
resolver
enst
ENSMUST00000091387
resolver
enst
ENSMUST00000221645
resolver
enst
ENSMUST00000221899
resolver
enst
ENSMUST00000222389
resolver
genesymbol
Polk
resolver
genesymbol_syn
Dinb1
resolver
uniprot
A0A1Y7VIV8
resolver
uniprot
A0A1Y7VLH7
resolver
uniprot
A0A1Y7VLU3
resolver
uniprot
F7D0M1
resolver
uniprot
Q3UUL1
resolver
uniprot
Q5Q9H0
resolver
uniprot
Q5Q9H6
resolver
uniprot
Q5Q9H7
resolver
uniprot
Q7TPY7
resolver
uniprot
Q9CRV6
resolver
uniprot_entry
A0A1Y7VIV8_MOUSE
resolver
uniprot_entry
A0A1Y7VLH7_MOUSE
resolver
uniprot_entry
A0A1Y7VLU3_MOUSE
resolver
uniprot_entry
F7D0M1_MOUSE
resolver
uniprot_entry
POLK_MOUSE
resolver
uniprot_entry
Q3UUL1_MOUSE
resolver
uniprot_entry
Q5Q9H0_MOUSE
resolver
uniprot_entry
Q5Q9H6_MOUSE
resolver
uniprot_entry
Q5Q9H7_MOUSE
resolver
uniprot_entry
Q9CRV6_MOUSE
resolver
uniprot_sec
Q7TPY7
resolver
amino_acid_sequence
MDNTKEKDNFKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDKFAMELERNRNLNNTIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQDWPEDKRRYFIKMGNYLKIDTPRQEANELTEYERSISPLLFEDSPPDLQPQGSPFQLNSEEQNNPQIAQNSVVFGTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQRALLSLLFSETSWHYFLHIALGLGSTDLARDGERKSMSVERTFSEISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELLRTEVNVGSPHPLRLRLMGVRMSTFSSEDDRKHQQRSIIGFLQAGNQALSSTGDSLDKTDKTELAKPLEMSHKKSFFDKKRSERISNCQDTSRCKTAGQQALQILEPSQALKKLSESFETSENSNDCQTFICPVCFREQEGVSLEAFNEHVDECLDGPSTSENSKISCYSHASSADIGQKEDVHPSIPLCEKRGHENGEITLVDGVDLTGTEDRSLKAARMDTLENNRSKEECPDIPDKSCPISLENETISTLSRQDSVQPCTDEVVTGRALVCPVCNLEQETSDLTLFNIHVDICLNKGIIQELRNSEGNSVKQPKESSRSTDRLQKASGRTKRPGTKTKSSTLKKTKPRDPRHTLDGFFK
uniprot
proteins
ec_number
2.7.7.7
uniprot
proteins
function
FUNCTION: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:12432099). Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity). {ECO:0000250|UniProtKB:Q9UBT6, ECO:0000269|PubMed:12432099}.
uniprot
proteins
mass_dalton
96003
uniprot
proteins
protein_family
DNA polymerase type-Y family
uniprot
proteins
pubmed
10518552
uniprot
proteins
pubmed
10620008
uniprot
proteins
pubmed
12432099
uniprot
proteins
pubmed
14657033
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22859295
uniprot
proteins
sequence_length
852
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UBT6}. Note=Detected throughout the nucleus and at replication foci. Recruited to DNA damage sites in response to ultraviolet irradiation: N6-methyladenosine (m6A)-containing mRNAs accumulate in the vicinity of DNA damage sites and their presence is required to recruit POLK. {ECO:0000250|UniProtKB:Q9UBT6}.
uniprot
proteins