Ppp2r2a
entrez
71978
canonical
uniprot
Q6P1F6
canonical
ensembl
ENSMUSG00000022052
resolver
ensp
ENSMUSP00000086640
resolver
ensp
ENSMUSP00000153191
resolver
enst
ENSMUST00000089230
resolver
enst
ENSMUST00000225380
resolver
genesymbol
Ppp2r2a
resolver
uniprot
A0A286YCX9
resolver
uniprot
Q3TT94
resolver
uniprot
Q9CWU3
resolver
uniprot_entry
2ABA_MOUSE
resolver
uniprot_entry
A0A286YCX9_MOUSE
resolver
uniprot_entry
Q3TT94_MOUSE
resolver
uniprot_entry
Q9CWU3_MOUSE
resolver
amino_acid_sequence
MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKVN
uniprot
proteins
function
FUNCTION: Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:39003739). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (PubMed:39003739). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (By similarity). {ECO:0000250|UniProtKB:P63151, ECO:0000269|PubMed:39003739}.
uniprot
proteins
mass_dalton
51692
uniprot
proteins
protein_family
Phosphatase 2A regulatory subunit B family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30611118
uniprot
proteins
pubmed
32582689
uniprot
proteins
pubmed
39003739
uniprot
proteins
sequence_length
447
uniprot
proteins