Rad51ap1
entrez
19362
canonical
uniprot
Q8C551
canonical
ensembl
ENSMUSG00000030346
resolver
ensp
ENSMUSP00000107839
resolver
ensp
ENSMUSP00000107841
resolver
enst
ENSMUST00000112220
resolver
enst
ENSMUST00000112221
resolver
genesymbol
Rad51ap1
resolver
uniprot
A0A0R4J1G4
resolver
uniprot
A0A0R4J1H1
resolver
uniprot
O55219
resolver
uniprot
Q8BP36
resolver
uniprot
Q99L94
resolver
uniprot
Q9D0J0
resolver
uniprot_entry
A0A0R4J1G4_MOUSE
resolver
uniprot_entry
A0A0R4J1H1_MOUSE
resolver
uniprot_entry
R51A1_MOUSE
resolver
uniprot_sec
O55219
resolver
uniprot_sec
Q8BP36
resolver
uniprot_sec
Q99L94
resolver
uniprot_sec
Q9D0J0
resolver
amino_acid_sequence
MVRPTRNRKPINYSQFEDSGNDSDDDFISSSTPVNKSKTVPKVLKQDKPKPNLKNLQKEEVLPTEPPKKRVALDDKVFQRGLEVALALSVKELPTLTNQVKKSKEKSTDKQGKEKTENTGKPPRVSNCSVASDDVEDLDKITEEGDASSVEGERKSPSQAKAPRRRAPSEGSDGSSANDTESESATGEGSESDPDFDESKESDEDFGVRRSKESKKKTVQKKPAGEKKERKSKPKCEASVTSVDPAPAAIKSGSPSLPQAVGLPSEATRKPAIMCSPSAESKRPKWVPPAASGSRNSSSNALAGTPAKSPSQSLRLGLSRLAPVKRLHPSATSSQVR
uniprot
proteins
function
FUNCTION: Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination. Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51. Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation. Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair. WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2. Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination. {ECO:0000250|UniProtKB:Q96B01}.
uniprot
proteins
mass_dalton
36227
uniprot
proteins
post_translational_modification
PTM: Sumoylation with SUMO2/3 by NSMCE2/MMS21 promotes stabilization, possibly by preventing ubiquitination. {ECO:0000250|UniProtKB:Q96B01}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21307306
uniprot
proteins
pubmed
9192668
uniprot
proteins
sequence_length
337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:21307306, ECO:0000269|PubMed:9192668}. Nucleus {ECO:0000269|PubMed:21307306, ECO:0000269|PubMed:9192668}. Chromosome, telomere {ECO:0000250|UniProtKB:Q96B01}. Note=Colocalizes with RAD51 to multiple nuclear foci (PubMed:21307306, PubMed:9192668). Colocalizes with DMC1 on meiotic chromatin (PubMed:21307306). {ECO:0000269|PubMed:21307306, ECO:0000269|PubMed:9192668}.
uniprot
proteins