Nkx1-2
entrez
20231
canonical
uniprot
P42580
canonical
ensembl
ENSMUSG00000048528
resolver
ensp
ENSMUSP00000052778
resolver
enst
ENSMUST00000054562
resolver
genesymbol
Nkx1-2
resolver
genesymbol_syn
Nkx1.1
resolver
genesymbol_syn
Sax1
resolver
uniprot
A4QPC3
resolver
uniprot
Q9JHF2
resolver
uniprot
Q9JKW5
resolver
uniprot
Q9JKW6
resolver
uniprot
Q9JKW9
resolver
uniprot
Q9JKX0
resolver
uniprot
Q9JKX1
resolver
uniprot_entry
NKX12_MOUSE
resolver
uniprot_sec
A4QPC3
resolver
uniprot_sec
Q9JHF2
resolver
uniprot_sec
Q9JKW5
resolver
uniprot_sec
Q9JKW6
resolver
uniprot_sec
Q9JKW9
resolver
uniprot_sec
Q9JKX0
resolver
uniprot_sec
Q9JKX1
resolver
amino_acid_sequence
MLAWQDVGAKAAPSHHKISFSVLDILDPQKFTRAALPPVRLAALEAKKSLEEVEAGQDACSGNPIGSQETPDAVGRGIDPGSPVEGSEAEEEEEAEDAGRAHQPERWQGVHEGSPEARAVAVGTEESGAEGLPASPGSPGSPRPRRRRAESSCAKPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADGAVQAGGGAPQPGTPGAVAGGGGSATGSSPGPPVPGALPYQTFPTYPATNVLFPAASFPLTTAANGSPFTPFLGPSYLTPFYAPHL
uniprot
proteins
function
FUNCTION: Transcriptional repressor (Probable). May play a role in early development as a Wnt/beta-catenin effector, hence controlling pluripotency and preimplantation development of embryonic stem cells (PubMed:38701778). May promote adipogenesis in mesenchymal stem cells, possibly by inhibiting the expression of the antiadipogenic factor NR2F2 (PubMed:31615896). May inhibit osteoblastogenic differentiation (PubMed:31615896). {ECO:0000269|PubMed:31615896, ECO:0000269|PubMed:38701778, ECO:0000305|PubMed:31615896}.
uniprot
proteins
mass_dalton
32013
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by HIPK2 in vitro. {ECO:0000269|PubMed:9748262}.
uniprot
proteins
protein_family
NK-1 homeobox family
uniprot
proteins
pubmed
10681422
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
31615896
uniprot
proteins
pubmed
38701778
uniprot
proteins
pubmed
7669696
uniprot
proteins
pubmed
9370304
uniprot
proteins
pubmed
9748262
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:38701778}. Nucleus, nucleolus {ECO:0000269|PubMed:38701778}. Note=In the very first hours following fertilization, at 0.5 dpc, found exclusively in the maternal pronucleus. Specifically localizes to the nucleoli of oocytes and preimplantation embryos. {ECO:0000269|PubMed:38701778}.
uniprot
proteins