Trim41
entrez
211007
canonical
uniprot
Q5NCC3
canonical
ensembl
ENSMUSG00000040365
resolver
ensp
ENSMUSP00000037055
resolver
enst
ENSMUST00000047145
resolver
genesymbol
Trim41
resolver
uniprot_entry
TRI41_MOUSE
resolver
amino_acid_sequence
MAAVAMTPNPVQTLQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLWGGEDEEDRDELDREEEEEEVGEEEEVEAVGAGGGWDTPMREEDYEGDMEEEAEEEEEVFWSSGIGGSNWDNMDYVWEEEEEEEEEELDYYLGDVADLRGEDEDEEEEVLEEDEEEELDPITQLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVNEQGICPRHQEALKLFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAANRLEEQAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEIQLQPPEIWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALLLSPDRRGVRLAERRQEVPEHSKRFSADCCVLGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGSGGSSVSSGDASSSRHHHRRRRLHLPQQLLLQREVWCVGTHGKRYQAQSSTEQTLLSPCEKPRRFGVYLDYEAGRLGFYNADTLAHVHTFSAAFLGERVFPFFRVLSKGTRIKLCP
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ligase that plays essential roles in innate antiviral response (PubMed:33640899). Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (By similarity). Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS (By similarity). Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (PubMed:33640899). Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (PubMed:30485814). {ECO:0000250|UniProtKB:Q8WV44, ECO:0000269|PubMed:30485814, ECO:0000269|PubMed:33640899}.
uniprot
proteins
mass_dalton
71818
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:33640899}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000250|UniProtKB:Q8WV44}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30485814
uniprot
proteins
pubmed
33640899
uniprot
proteins
sequence_length
630
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:33640899}. Nucleus {ECO:0000250|UniProtKB:Q8WV44}.
uniprot
proteins