HEXIM1
entrez
10614
canonical
uniprot
O94992
canonical
ensembl
ENSG00000186834
resolver
ensp
ENSP00000328773
resolver
enst
ENST00000332499
resolver
genesymbol
HEXIM1
resolver
genesymbol_syn
CLP1
resolver
genesymbol_syn
EDG1
resolver
genesymbol_syn
HIS1
resolver
genesymbol_syn
MAQ1
resolver
hgnc
HGNC:24953
resolver
uniprot
B2R8Y5
resolver
uniprot_entry
HEXI1_HUMAN
resolver
uniprot_sec
B2R8Y5
resolver
amino_acid_sequence
MAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEEDSRWQSRAFPQLGGRPGPEGEGSLESQPPPLQTQACPESSCLREGEKGQNGDDSSAGGDFPPPAEVEPTPEAELLAQPCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYSKRAAAKSDDTSDDDFMEEGGEEDGGSDGMGGDGSEFLQRDFSETYERYHTESLQNMSKQELIKEYLELEKCLSRMEDENNRLRLESKRLGGDDARVRELELELDRLRAENLQLLTENELHRQQERAPLSKFGD
uniprot
proteins
function
FUNCTION: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}.
uniprot
proteins
mass_dalton
40623
uniprot
proteins
mutagenesis
MUTAGEN 152..155; /note="KHRR->ILAA: Abolishes interaction with 7SK snRNA."; /evidence="ECO:0000269|PubMed:15201869"; MUTAGEN 154..156; /note="RRR->AAA: Abolishes interaction with 7SK snRNA."; /evidence="ECO:0000269|PubMed:16362050"; MUTAGEN 203; /note="Y->D: Abolishes interaction with P-TEFb; when associated with D-205."; /evidence="ECO:0000269|PubMed:15201869"; MUTAGEN 205; /note="T->D: Abolishes interaction with P-TEFb. Same effect; when associated with D-203."; /evidence="ECO:0000269|PubMed:15201869"; MUTAGEN 208; /note="F->A,D,K: Partial loss of function."; /evidence="ECO:0000269|PubMed:15965233"; MUTAGEN 271; /note="Y->A,E: Loss of function."; /evidence="ECO:0000269|PubMed:15965233"; MUTAGEN 287; /note="L->A: Loss of oligomerization; when associated with A-294; A-332 and A-339. Loss of function and interaction with P-TEFb; when associated with A-294."; /evidence="ECO:0000269|PubMed:16377779"; MUTAGEN 294; /note="L->A: Loss of oligomerization; when associated with A-287; A-332 and A-339. Loss of function and interaction with P-TEFb; when associated with A-287."; /evidence="ECO:0000269|PubMed:16377779"; MUTAGEN 332; /note="L->A: Loss of oligomerization; when associated with A-287; A-294 and A-339."; /evidence="ECO:0000269|PubMed:16377779"; MUTAGEN 339; /note="L->A: Loss of oligomerization; when associated with A-287; A-294 and A-332."; /evidence="ECO:0000269|PubMed:16377779
uniprot
proteins
protein_family
HEXIM family
uniprot
proteins
pubmed
12581153
uniprot
proteins
pubmed
12832472
uniprot
proteins
pubmed
12941847
uniprot
proteins
pubmed
14580347
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15169877
uniprot
proteins
pubmed
15201869
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15713661
uniprot
proteins
pubmed
15855166
uniprot
proteins
pubmed
15940264
uniprot
proteins
pubmed
15941832
uniprot
proteins
pubmed
15965233
uniprot
proteins
pubmed
16362050
uniprot
proteins
pubmed
16377779
uniprot
proteins
pubmed
17088550
uniprot
proteins
pubmed
17395637
uniprot
proteins
pubmed
17452463
uniprot
proteins
pubmed
17643375
uniprot
proteins
pubmed
17724342
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19883659
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28712728
uniprot
proteins
pubmed
30134174
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:12941847, ECO:0000269|PubMed:16362050, ECO:0000269|PubMed:17395637}. Cytoplasm {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:17395637}. Note=Binds alpha-importin and is mostly nuclear (PubMed:16362050).
uniprot
proteins