SQLE
entrez
6713
canonical
uniprot
Q14534
canonical
ensembl
ENSG00000104549
resolver
ensp
ENSP00000265896
resolver
ensp
ENSP00000430331
resolver
enst
ENST00000265896
resolver
genesymbol
SQLE
resolver
genesymbol_syn
ERG1
resolver
hgnc
HGNC:11279
resolver
uniprot
Q9UEK6
resolver
uniprot
Q9UNR6
resolver
uniprot_entry
ERG1_HUMAN
resolver
uniprot_sec
Q9UEK6
resolver
uniprot_sec
Q9UNR6
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by NB-598 ((E)N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-[(3,3'-bi-thiophen-5-yl)methoxy]benzene-methanamine). Contrary to fungal enzymes, the mammalian enzyme is only slightly inhibited by terbinafine (PubMed:30626872). Inhibited by tellurite, tellurium dioxide, selenite, and selenium dioxide (PubMed:10666321). {ECO:0000269|PubMed:10666321, ECO:0000269|PubMed:30626872}.
uniprot
proteins
amino_acid_sequence
MWTFLGIATFTYFYKKFGDFITLANREVLLCVLVFLSLGLVLSYRCRHRNGGLLGRQQSGSQFALFSDILSGLPFIGFFWAKSPPESENKEQLEARRRRKGTNISETSLIGTAACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIFPLIYSEMKYMVH
uniprot
proteins
ec_number
1.14.14.17
uniprot
proteins
function
FUNCTION: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. {ECO:0000269|PubMed:10666321, ECO:0000269|PubMed:30626872}.
uniprot
proteins
mass_dalton
63923
uniprot
proteins
mutagenesis
MUTAGEN 35; /note="F->A: Increased expression levels and decreased degradation in response to high membrane cholesterol levels; when associated with A-37; A-65 and A-69."; /evidence="ECO:0000269|PubMed:28972164"; MUTAGEN 37; /note="S->A: Increased expression levels and decreased degradation in response to high membrane cholesterol levels; when associated with A-35; A-65 and A-69."; /evidence="ECO:0000269|PubMed:28972164"; MUTAGEN 62..73; /note="Missing: Abolishes degradation in response to high membrane cholesterol levels."; /evidence="ECO:0000269|PubMed:28972164"; MUTAGEN 65; /note="L->A: Increased expression levels and decreased degradation in response to high membrane cholesterol levels; when associated with A-35; A-37 and A-69."; /evidence="ECO:0000269|PubMed:28972164"; MUTAGEN 69; /note="I->A: Increased expression levels and decreased degradation in response to high membrane cholesterol levels; when associated with A-35; A-37 and A-65."; /evidence="ECO:0000269|PubMed:28972164"; MUTAGEN 195; /note="Y->A,F: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:30626872
uniprot
proteins
pathway_participation
PATHWAY: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3. {ECO:0000269|PubMed:24449766, ECO:0000305|PubMed:10666321, ECO:0000305|PubMed:30626872}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MARCHF6 in response to high cholesterol levels in intracellular membranes, leading to proteasomal degradation. {ECO:0000269|PubMed:24449766}.
uniprot
proteins
protein_family
Squalene monooxygenase family
uniprot
proteins
pubmed
10666321
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24449766
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26434806
uniprot
proteins
pubmed
28972164
uniprot
proteins
pubmed
29765154
uniprot
proteins
pubmed
30626872
uniprot
proteins
pubmed
8626488
uniprot
proteins
pubmed
9286711
uniprot
proteins
sequence_length
574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:26434806, ECO:0000269|PubMed:28972164, ECO:0000269|PubMed:30626872}; Peripheral membrane protein {ECO:0000269|PubMed:26434806, ECO:0000269|PubMed:28972164}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:26434806}; Peripheral membrane protein {ECO:0000269|PubMed:26434806, ECO:0000269|PubMed:28972164}.
uniprot
proteins