CDK16
entrez
5127
canonical
uniprot
Q00536
canonical
ensembl
ENSG00000102225
resolver
ensp
ENSP00000276052
resolver
ensp
ENSP00000349762
resolver
ensp
ENSP00000405798
resolver
ensp
ENSP00000708909
resolver
ensp
ENSP00000793540
resolver
genesymbol
CDK16
resolver
genesymbol
PCTK1
resolver
genesymbol_syn
PCTAIRE1
resolver
genesymbol_syn
PCTK1
resolver
hgnc
HGNC:8749
resolver
uniprot
A0A140VK97
resolver
uniprot
A8K280
resolver
uniprot
B7Z7C8
resolver
uniprot
J3KN74
resolver
uniprot
J3KQP7
resolver
uniprot
Q9BRL4
resolver
uniprot_entry
A0A140VK97_HUMAN
resolver
uniprot_entry
CDK16_HUMAN
resolver
uniprot_entry
Q9BRL4_HUMAN
resolver
uniprot_sec
A8K280
resolver
uniprot_sec
B7Z7C8
resolver
uniprot_sec
J3KN74
resolver
uniprot_sec
J3KQP7
resolver
amino_acid_sequence
MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSGRPAFRVVDTEF
uniprot
proteins
ec_number
2.7.11.22
uniprot
proteins
function
FUNCTION: Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}.
uniprot
proteins
mass_dalton
55716
uniprot
proteins
mutagenesis
MUTAGEN 12; /note="S->A: Abolishes phosphorylation by BRSK2. Abolishes effect on insulin secretion."; /evidence="ECO:0000269|PubMed:22798068"; MUTAGEN 119; /note="S->A: Strongly reduces interaction with CCNY."; /evidence="ECO:0000269|PubMed:22184064"; MUTAGEN 153; /note="S->A: Constitutively activated, due to loss of an inhibitory phosphorylation site. Increases interaction with CCNY."; /evidence="ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22798068"; MUTAGEN 153; /note="S->D: Abolishes interaction with CCNY."; /evidence="ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22798068"; MUTAGEN 194; /note="K->A: Loss of kinase activity. Abolishes effect on insulin secretion."; /evidence="ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22798068"; MUTAGEN 194; /note="K->R: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22798068
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of CDK16 is essential for the binding of CCNY, but also essential for the regulation of CDK16 kinase activity (PubMed:22798068). Phosphorylation of CDK16 is essential for the binding of CCNYl1, but also essential for the regulation of CDK16 kinase activity (By similarity). Ser-146 and Ser-153 are the most critical sites for the binding of CCNYL1 and for modulating CDK16 kinase activity (By similarity). Phosphorylation at Ser-153 inhibits kinase activity (PubMed:22798068). {ECO:0000250|UniProtKB:Q04735, ECO:0000269|PubMed:22798068}.
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
1639063
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22184064
uniprot
proteins
pubmed
22796189
uniprot
proteins
pubmed
22798068
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22798068}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q63686}. Cell membrane {ECO:0000269|PubMed:22184064}; Peripheral membrane protein {ECO:0000269|PubMed:22184064}; Cytoplasmic side {ECO:0000269|PubMed:22184064}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q63686}. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY.
uniprot
proteins