Cilk1
entrez
56542
canonical
uniprot
Q9JKV2
canonical
ensembl
ENSMUSG00000009828
resolver
ensp
ENSMUSP00000048234
resolver
ensp
ENSMUSP00000112961
resolver
ensp
ENSMUSP00000333157
resolver
enst
ENSMUST00000044551
resolver
enst
ENSMUST00000118869
resolver
genesymbol
Cilk1
resolver
genesymbol_syn
Ick
resolver
genesymbol_syn
mKIAA0936
resolver
uniprot
Q69ZV0
resolver
uniprot
Q8K138
resolver
uniprot_entry
CILK1_MOUSE
resolver
uniprot_entry
Q69ZV0_MOUSE
resolver
uniprot_sec
Q8K138
resolver
amino_acid_sequence
MNRYTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANIVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDIWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFLWPQCIPNNLKTLIPNASSEAIQLLRDLLQWDPKKRPTASQALRYPYFQIGHPLGIISKDSGKPQREVQDKTGPPPYIKPAPPAQAPAKAYTLISSRPSQASQPPQHSVHPYKGDVSRTEQLSHVQEGKPSPPFFPSLHNKNLQPKILASLEQKNGEIKPKSRRRWGLISRSTKGSDDWADLDDLDFSPSLTRIDVKNKKRQSDDTLCRFESVLDLKPSESVGTGTTVSTQASSQRRDTPTLQSSAKQHYLKHSRYLPGINIRNGVLPNPGKDFLPSNSWSSSGLSGKSSGTVSVVSKITSVGSGSASSSGLTGSYIPSFLKKEIGSVMQRVQLAPLAAPPPGYSSLKAVRPHPGRPFFHTQPRSTPGLIPRPPAAQPVHGRIDWSSKYPSRR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Has an essential role in ciliogenesis, particularly in neuronal and retinal progenitor cells (PubMed:24797473). Phosphorylates KIF3A (PubMed:24797473). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (PubMed:24797473, PubMed:24853502). May play a role in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling -dependent manner and this regulation requires its kinase activity (PubMed:25243405). {ECO:0000250|UniProtKB:Q62726, ECO:0000269|PubMed:24797473, ECO:0000269|PubMed:24853502, ECO:0000269|PubMed:25243405}.
uniprot
proteins
mass_dalton
70592
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="K->M: No effect on cilium length."; /evidence="ECO:0000269|PubMed:25243405"; MUTAGEN 33; /note="K->R: Loss of kinase activity; no effect on nuclear subcellular location."; /evidence="ECO:0000269|PubMed:15988018"; MUTAGEN 157..159; /note="TDY->ADF: Loss of kinase activity and of autophosphorylation; loss of phosphorylation by CDK7; no effect on nuclear subcellular location."; /evidence="ECO:0000269|PubMed:15988018"; MUTAGEN 157; /note="T->A: Loss of kinase activity; loss of phosphorylation by CDK7; no effect on autophosphorylation."; /evidence="ECO:0000269|PubMed:15988018"; MUTAGEN 159; /note="Y->F: Loss of kinase activity and of autophosphorylation; no effect on phosphorylation by CDK7."; /evidence="ECO:0000269|PubMed:15988018"; MUTAGEN 169; /note="E->A: Complete loss of kinase activity and of nuclear localization."; /evidence="ECO:0000269|PubMed:15988018"; MUTAGEN 184; /note="W->A: Complete loss of kinase activity and of nuclear localization."; /evidence="ECO:0000269|PubMed:15988018"; MUTAGEN 270; /note="K->A: Partial loss of autocatalytic kinase activity. Complete loss of kinase activity and of nuclear localization; when associated with A-271 and A-272."; /evidence="ECO:0000269|PubMed:15988018"; MUTAGEN 271; /note="K->A: Partial loss of kinase activity. Complete loss of kinase activity and of nuclear localization; when associated with A-270 and A-272."; /evidence="ECO:0000269|PubMed:15988018"; MUTAGEN 272; /note="R->A: Complete loss of kinase activity and of nuclear localization. Complete loss of kinase activity and of nuclear localization; when associated with A-270 and A-272."; /evidence="ECO:0000269|PubMed:15988018
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-157 by CDK7/Cak1p increases kinase activity. {ECO:0000269|PubMed:15988018}.
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10699974
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15988018
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24797473
uniprot
proteins
pubmed
24853502
uniprot
proteins
pubmed
25243405
uniprot
proteins
pubmed
29539279
uniprot
proteins
sequence_length
629
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q62726}. Cell projection, cilium {ECO:0000269|PubMed:24797473, ECO:0000269|PubMed:25243405}. Nucleus {ECO:0000269|PubMed:15988018, ECO:0000269|PubMed:25243405}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24853502}. Note=Also found at the ciliary tip (PubMed:24797473). Predominant nuclear localization has been observed with a N-terminally GFP-tagged construct in transfected COS-7 cells (PubMed:15988018). {ECO:0000269|PubMed:15988018, ECO:0000269|PubMed:24797473}.
uniprot
proteins