Tgfb1i1
entrez
21804
canonical
uniprot
Q62219
canonical
ensembl
ENSMUSG00000030782
resolver
ensp
ENSMUSP00000130964
resolver
ensp
ENSMUSP00000132100
resolver
ensp
ENSMUSP00000321272
resolver
ensp
ENSMUSP00000321274
resolver
ensp
ENSMUSP00000321276
resolver
genesymbol
Tgfb1i1
resolver
genesymbol_syn
Ara55
resolver
uniprot
Q3YBY7
resolver
uniprot
Q3YBY8
resolver
uniprot
Q3YBZ0
resolver
uniprot
Q3YBZ1
resolver
uniprot
Q3YBZ3
resolver
uniprot
Q3YBZ4
resolver
uniprot
Q3YBZ5
resolver
uniprot
Q3YBZ6
resolver
uniprot_entry
TGFI1_MOUSE
resolver
uniprot_sec
Q3YBY7
resolver
uniprot_sec
Q3YBY8
resolver
uniprot_sec
Q3YBZ0
resolver
uniprot_sec
Q3YBZ1
resolver
uniprot_sec
Q3YBZ3
resolver
uniprot_sec
Q3YBZ4
resolver
uniprot_sec
Q3YBZ5
resolver
uniprot_sec
Q3YBZ6
resolver
amino_acid_sequence
MEDLDALLSDLETTTSHMSRLGAPKERPPETLTPPPPYGHQPQTGSGESSGTTGDKDHLYSTVCKPRSPKPVAPVAPPFSSSSGVLGNGLCELDRLLQELNATQFNITDEIMSQFPSSKMAEGEEKEDQSEDKSSPTVPPSPFPAPSKPSATSATQELDRLMASLSDFRVQNHLPASGPPQPPAASPTREGCPSPPGQTSKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFLCSGCSTTLGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGEEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECLAPFSGGSFFEHEGRPLCENHFHAQRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERASKPYCQPCFLKLFG
uniprot
proteins
function
FUNCTION: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10649439, ECO:0000269|PubMed:10848625, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11546764, ECO:0000269|PubMed:11937715, ECO:0000269|PubMed:12153727, ECO:0000269|PubMed:14755691, ECO:0000269|PubMed:15687259, ECO:0000269|PubMed:15713747, ECO:0000269|PubMed:16183059, ECO:0000269|PubMed:16291758, ECO:0000269|PubMed:16737959, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:17299801, ECO:0000269|PubMed:7929412, ECO:0000269|PubMed:9722648}.
uniprot
proteins
mass_dalton
50101
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="Y->F: Reduced phosphorylation. Loss of phosphorylation; when associated with F-60."; /evidence="ECO:0000269|PubMed:16183059"; MUTAGEN 60; /note="Y->F: Reduced phosphorylation. Loss of phosphorylation; when associated with F-38."; /evidence="ECO:0000269|PubMed:16183059"; MUTAGEN 64; /note="C->N: Increase in nuclear localization."; /evidence="ECO:0000269|PubMed:12631731"; MUTAGEN 91; /note="C->S: Increase in nuclear localization."; /evidence="ECO:0000269|PubMed:12631731"; MUTAGEN 161; /note="L->A: Increase in nuclear localization."; /evidence="ECO:0000269|PubMed:12631731"; MUTAGEN 366; /note="H->G: Loss of interaction with PTPN12; when associated with G-369."; /evidence="ECO:0000269|PubMed:10092676"; MUTAGEN 369; /note="C->A: Loss of localization to focal adhesion; when associated with A-372."; /evidence="ECO:0000269|PubMed:10092676, ECO:0000269|PubMed:16183059"; MUTAGEN 369; /note="C->G: Loss of interaction with PTPN12; when associated with G-366."; /evidence="ECO:0000269|PubMed:10092676, ECO:0000269|PubMed:16183059"; MUTAGEN 372; /note="C->A: Loss of localization to focal adhesion; when associated with A-369."; /evidence="ECO:0000269|PubMed:16183059
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by gonadotropin-releasing hormone-activated SRC. {ECO:0000250}.
uniprot
proteins
protein_family
Paxillin family
uniprot
proteins
pubmed
10092676
uniprot
proteins
pubmed
10330411
uniprot
proteins
pubmed
10649439
uniprot
proteins
pubmed
10831843
uniprot
proteins
pubmed
10848625
uniprot
proteins
pubmed
11134073
uniprot
proteins
pubmed
11437454
uniprot
proteins
pubmed
11463817
uniprot
proteins
pubmed
11546764
uniprot
proteins
pubmed
11779876
uniprot
proteins
pubmed
11805099
uniprot
proteins
pubmed
11937715
uniprot
proteins
pubmed
12153727
uniprot
proteins
pubmed
12177201
uniprot
proteins
pubmed
12631731
uniprot
proteins
pubmed
14755691
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15687259
uniprot
proteins
pubmed
15713747
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16183059
uniprot
proteins
pubmed
16219310
uniprot
proteins
pubmed
16219691
uniprot
proteins
pubmed
16291758
uniprot
proteins
pubmed
16624805
uniprot
proteins
pubmed
16737959
uniprot
proteins
pubmed
17166536
uniprot
proteins
pubmed
17233630
uniprot
proteins
pubmed
17299801
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7929412
uniprot
proteins
pubmed
9422762
uniprot
proteins
pubmed
9722648
uniprot
proteins
pubmed
9756887
uniprot
proteins
pubmed
9858471
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton, colocalizes with stress fibers.
uniprot
proteins