Odc1
entrez
18263
canonical
uniprot
P00860
canonical
ensembl
ENSMUSG00000011179
resolver
ensp
ENSMUSP00000128661
resolver
ensp
ENSMUSP00000279059
resolver
ensp
ENSMUSP00000279060
resolver
ensp
ENSMUSP00000279061
resolver
ensp
ENSMUSP00000279063
resolver
ensp
ENSMUSP00000279064
resolver
ensp
ENSMUSP00000279065
resolver
ensp
ENSMUSP00000279069
resolver
ensp
ENSMUSP00000279072
resolver
ensp
ENSMUSP00000336017
resolver
ensp
ENSMUSP00000336018
resolver
ensp
ENSMUSP00000336019
resolver
enst
ENSMUST00000171737
resolver
genesymbol
Odc1
resolver
genesymbol_syn
Odc
resolver
uniprot
Q61997
resolver
uniprot
Q61998
resolver
uniprot
Q6PB87
resolver
uniprot_entry
DCOR_MOUSE
resolver
uniprot_sec
Q61997
resolver
uniprot_sec
Q61998
resolver
uniprot_sec
Q6PB87
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by antizymes (AZs) OAZ1, OAZ2 and OAZ3 in response to polyamine levels. AZs inhibit the assembly of the functional homodimer by binding to ODC monomers. Additionally, OAZ1 targets ODC monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. {ECO:0000250|UniProtKB:P11926}.
uniprot
proteins
amino_acid_sequence
MSSFTKDEFDCHILDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSRAIVSTLAAIGTGFDCASKTEIQLVQGLGVPAERVIYANPCKQVSQIKYAASNGVQMMTFDSEIELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLKTSRLLLERAKELNIDVIGVSFHVGSGCTDPETFVQAVSDARCVFDMATEVGFSMHLLDIGGGFPGSEDTKLKFEEITSVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKTVWKEQPGSDDEDESNEQTFMYYVNDGVYGSFNCILYDHAHVKALLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCNLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPNIYYVMSRPMWQLMKQIQSHGFPPEVEEQDDGTLPMSCAQESGMDRHPAACASARINV
uniprot
proteins
ec_number
4.1.1.17
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. {ECO:0000269|PubMed:18973822, ECO:0000269|PubMed:24967154}.
uniprot
proteins
mass_dalton
51177
uniprot
proteins
mutagenesis
MUTAGEN 387; /note="G->A: Partial loss of activity."; /evidence="ECO:0000269|PubMed:8243470"; MUTAGEN 387; /note="G->C,D,E,F,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y: Loss of activity."; /evidence="ECO:0000269|PubMed:8243470
uniprot
proteins
pathway_participation
PATHWAY: Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
uniprot
proteins
protein_family
Orn/Lys/Arg decarboxylase class-II family
uniprot
proteins
pubmed
10378276
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1730582
uniprot
proteins
pubmed
18973822
uniprot
proteins
pubmed
2026163
uniprot
proteins
pubmed
24967154
uniprot
proteins
pubmed
2982844
uniprot
proteins
pubmed
3362685
uniprot
proteins
pubmed
3372502
uniprot
proteins
pubmed
3456155
uniprot
proteins
pubmed
3856848
uniprot
proteins
pubmed
8106349
uniprot
proteins
pubmed
8243470
uniprot
proteins
pubmed
8350350
uniprot
proteins
pubmed
8504104
uniprot
proteins
sequence_length
461
uniprot
proteins