Slamf6
entrez
30925
canonical
uniprot
Q9ET39
canonical
ensembl
ENSMUSG00000015314
resolver
ensp
ENSMUSP00000130610
resolver
ensp
ENSMUSP00000141448
resolver
ensp
ENSMUSP00000141944
resolver
ensp
ENSMUSP00000167349
resolver
genesymbol
Slamf6
resolver
genesymbol_syn
Ly108
resolver
genesymbol_syn
Ly108s
resolver
uniprot
C6ESQ1
resolver
uniprot
Q18PG5
resolver
uniprot
Q18PJ0
resolver
uniprot
Q9ET40
resolver
uniprot_entry
Q18PG5_MOUSE
resolver
uniprot_entry
Q18PJ0_MOUSE
resolver
uniprot_entry
SLAF6_MOUSE
resolver
uniprot_sec
C6ESQ1
resolver
uniprot_sec
Q9ET40
resolver
amino_acid_sequence
MAVSRAPAPDSACQRMVWLFPLVFCLGSGSEVSQSSSDPQLMNGVLGESAVLPLKLPAGKIANIIIWNYEWEASQVTALVINLSNPESPQIMNTDVKKRLNITQSYSLQISNLTMADTGSYTAQITTKDSEVITFKYILRVFERLGNLETTNYTLLLENGTCQIHLACVLKNQSQTVSVEWQATGNISLGGPNVTIFWDPRNSGDQTYVCRAKNAVSNLSVSVSTQSLCKGVLTNPPWNAVWFMTTISIISAVILIFVCWSIHVWKRRGSLPLTSQHPESSQSTDGPGSPGNTVYAQVTRPMQEMKIPKPIKNDSMTIYSIVNHSREETVALTGYNQPITLKVNTLINYNS
uniprot
proteins
function
FUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:19648922). Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (By similarity). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (By similarity). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (PubMed:18031695). Promotes T cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (By similarity). Promotes recruitment of RORC to the IL-17 promoter (By similarity). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response (PubMed:25926831). In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP (PubMed:22683125). However, reported to mediated T-cell adhesion, to participate in stable T-cell:B-cell interactions and to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (PubMed:20153220, PubMed:25801429). Involved in regulation of autoimmunity. Isoform 3 may be suppressor of pathogenic T-cell proliferation (PubMed:21422172). {ECO:0000250|UniProtKB:Q96DU3, ECO:0000269|PubMed:18031695, ECO:0000269|PubMed:19648922, ECO:0000269|PubMed:20153220, ECO:0000269|PubMed:21422172, ECO:0000269|PubMed:22683125, ECO:0000269|PubMed:25801429}.
uniprot
proteins
mass_dalton
38638
uniprot
proteins
mutagenesis
MUTAGEN 295; /note="Y->F: Decreases inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-319 and F-349."; /evidence="ECO:0000269|PubMed:22683125"; MUTAGEN 295; /note="Y->F: Strong inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-335 and F-349."; /evidence="ECO:0000269|PubMed:22683125"; MUTAGEN 319; /note="Y->F: Decreases inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-295 and F-349."; /evidence="ECO:0000269|PubMed:22683125"; MUTAGEN 319; /note="Y->F: Strong inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-335 and F-349."; /evidence="ECO:0000269|PubMed:22683125"; MUTAGEN 335; /note="Y->F: Strong inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-295 and F-349."; /evidence="ECO:0000269|PubMed:22683125"; MUTAGEN 335; /note="Y->F: Strong inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-319 and F-349."; /evidence="ECO:0000269|PubMed:22683125"; MUTAGEN 349; /note="Y->F: Decreases inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-295 and F-319."; /evidence="ECO:0000269|PubMed:22683125"; MUTAGEN 349; /note="Y->F: Strong inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-295 and F-335."; /evidence="ECO:0000269|PubMed:22683125"; MUTAGEN 349; /note="Y->F: Strong inhibitory signaling in germinal center formation (absence of SH2D1A/SAP); when associated with F-319 and F-335."; /evidence="ECO:0000269|PubMed:22683125
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250}.
uniprot
proteins
pubmed
11132158
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18031695
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19648922
uniprot
proteins
pubmed
20153220
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21422172
uniprot
proteins
pubmed
22683125
uniprot
proteins
pubmed
25801429
uniprot
proteins
pubmed
25926831
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 240..262; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins