Nacc1
entrez
171454
canonical
uniprot
O35260
canonical
ensembl
ENSRNOG00000002864
resolver
ensp
ENSRNOP00000071927
resolver
ensp
ENSRNOP00000108418
resolver
genesymbol
Nacc1
resolver
genesymbol_syn
Btbd14b
resolver
genesymbol_syn
Nac1
resolver
uniprot_entry
NACC1_RAT
resolver
amino_acid_sequence
MAQTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQILTFCYTGRLSMNMGDQFLLIYTAGFLQIQEIMEKGTEFFLKVSSPSCDSQGLHPEEAPSSEPQSPVAQILGWPACSTPLPLVSRVKTEQELDSVQCTPMAKRLWDSSQKEAGGSGGNNGSRKMAKFSTPDLAPNRMPQPVSVATATAAVAVVAVGGCVSGPSMSERTSPGTSSAYTSDSPSSYHNEEDEEEDAGEEGTDEQYRQICNMYTMYSMLNVGQTVEKVEALPEQVVLESHSRIRVRQDLASLPAELINQIGNRCHPKLYDEGDPSEKLELVTGTNVYITRAQLMNCHVSAGTRHKVLLRRLLASFFDRNTLANSCGTGIRSSTNDPRRKPLDSRVLHAVKYYCQNFAPNFKESEMNAIAADMCTNARRVVRKSWLPKTKPLHLVEGDNYSSFISDTGKIEPDMMSMEHSFETASHDGEAGPSAEVLQ
uniprot
proteins
function
FUNCTION: Functions as a transcriptional repressor. Isoform 1 is a stronger transcriptional repressor than isoform 2. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. {ECO:0000269|PubMed:11906783, ECO:0000269|PubMed:16033423, ECO:0000269|PubMed:17254023, ECO:0000269|PubMed:17699672}.
uniprot
proteins
mass_dalton
56450
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="Q->L: Abrogates transcriptional repression."; /evidence="ECO:0000269|PubMed:17254023
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by protein kinase C (PKC). {ECO:0000269|PubMed:16045493}.
uniprot
proteins
pubmed
11906783
uniprot
proteins
pubmed
16033423
uniprot
proteins
pubmed
16045493
uniprot
proteins
pubmed
17254023
uniprot
proteins
pubmed
17699672
uniprot
proteins
pubmed
9278521
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Punctate distribution in nucleus. In differentiated PC12 cells diffusely distributed in the cytoplasm and is dependent on phosphorylation.
uniprot
proteins