ACVR1C
entrez
130399
canonical
uniprot
Q8NER5
canonical
ensembl
ENSG00000123612
resolver
ensp
ENSP00000243349
resolver
ensp
ENSP00000335139
resolver
ensp
ENSP00000335178
resolver
ensp
ENSP00000387168
resolver
genesymbol
ACVR1C
resolver
genesymbol_syn
ALK7
resolver
hgnc
HGNC:18123
resolver
uniprot
Q4ZFZ8
resolver
uniprot
Q86UL1
resolver
uniprot
Q86UL2
resolver
uniprot
Q8TBG2
resolver
uniprot_entry
ACV1C_HUMAN
resolver
uniprot_sec
Q4ZFZ8
resolver
uniprot_sec
Q86UL1
resolver
uniprot_sec
Q86UL2
resolver
uniprot_sec
Q8TBG2
resolver
amino_acid_sequence
MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA
uniprot
proteins
ec_number
2.7.11.30
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells (PubMed:15531507, PubMed:15150278). Acts as a positive regulator for macrophage activation partially through down-regulation of PPARG expression (By similarity). {ECO:0000250|UniProtKB:P70539, ECO:0000250|UniProtKB:Q8K348, ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:15150278, ECO:0000269|PubMed:15531507}.
uniprot
proteins
mass_dalton
54871
uniprot
proteins
mutagenesis
MUTAGEN 194; /note="T->D: Pro-apoptotic."; /evidence="ECO:0000269|PubMed:15531507"; MUTAGEN 222; /note="K->R: Loss of response to NODAL and SMAD2 phosphorylation."; /evidence="ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:15150278, ECO:0000269|PubMed:15531507
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TGFB receptor subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
12063393
uniprot
proteins
pubmed
12606401
uniprot
proteins
pubmed
15150278
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15531507
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17344846
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12606401}; Single-pass type I membrane protein {ECO:0000269|PubMed:12606401}.
uniprot
proteins
transmembrane_region
TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins