P59823
uniprot
P59823
canonical
amino_acid_sequence
MKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSVDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKAWRPSIVFKRDTLLIKEVKEDDIGNYTCELKYGGFVVRRTTELTVTAPLTDKPPKLLYPMESKLTVQETQLGGSANLTCRAFFGYSGDVSPLIYWMKGEKFIEDLDENRVWESDIRILKEHLGEQEVSISLIVDSVEEGDLGNYSCYVENGNGRRHASVLLHKRELMYTVELAGGLGAILLLLICSVTIYKCYKIEIMLFYRNHFGAEELDGDNKDYDAYLSYTKVDPDQWNQETGEEERFALEILPDMLEKHYGYKLFIPDRDLIPTGNIEDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNMLVTGEIKVILIECSELRGIMNYQEVEALKHTIKLLTVIKWHGPKCNKLNSKFWKRLQYEMPFKRIEPITHEQALDVSEQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNTYHSQMRQKHYYRSYEYDVPPTGTLPLTSIGNQHTYCNIPMTLINGQRPQTKSNREPNPDEAHTNSAILPLLPRETSISSVIW
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK (By similarity). Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (PubMed:21940441, PubMed:25908590). {ECO:0000250|UniProtKB:P59824, ECO:0000250|UniProtKB:Q9NZN1, ECO:0000269|PubMed:21940441, ECO:0000269|PubMed:25908590}.
uniprot
proteins
mass_dalton
79630
uniprot
proteins
mutagenesis
MUTAGEN 34; /note="W->A: Abolishes Interaction with PTPRD. Abolishes synaptogenesis."; /evidence="ECO:0000269|PubMed:25908590"; MUTAGEN 37; /note="D->A: Decreases affinity for PTPRD. Significantly decreases synaptogenesis."; /evidence="ECO:0000269|PubMed:25908590"; MUTAGEN 75..77; /note="MWY->AWA: Decreases affinity for PTPRD; when associated with 88-A--A-91. Significantly decreases synaptogenesis; when associated with 88-A--A-91."; /evidence="ECO:0000269|PubMed:25908590"; MUTAGEN 88..91; /note="PIAF->AIAA: Decreases affinity for PTPRD; when associated with 75-A--A-77. Significantly decreases synaptogenesis; when associated with 88-A--A-91."; /evidence="ECO:0000269|PubMed:25908590"; MUTAGEN 292; /note="D->A: Decreases affinity for PTPRD. Significantly decreases synaptogenesis."; /evidence="ECO:0000269|PubMed:25908590
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
12783849
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21940441
uniprot
proteins
pubmed
25908590
uniprot
proteins
sequence_length
695
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection, axon {ECO:0000269|PubMed:21940441}. Cell projection, dendrite {ECO:0000269|PubMed:21940441}. Note=May localize to the cell body and growth cones of dendrite-like processes.
uniprot
proteins
transmembrane_region
TRANSMEM 358..378; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins