MATR3
entrez
9782
canonical
uniprot
P43243
canonical
ensembl
ENSG00000015479
resolver
ensembl
ENSG00000280987
resolver
ensp
ENSP00000354346
resolver
ensp
ENSP00000378279
resolver
ensp
ENSP00000378284
resolver
ensp
ENSP00000421218
resolver
ensp
ENSP00000422319
resolver
ensp
ENSP00000423533
resolver
ensp
ENSP00000423587
resolver
ensp
ENSP00000426030
resolver
ensp
ENSP00000482895
resolver
ensp
ENSP00000580073
resolver
ensp
ENSP00000580075
resolver
ensp
ENSP00000580087
resolver
ensp
ENSP00000598265
resolver
ensp
ENSP00000598266
resolver
ensp
ENSP00000625776
resolver
ensp
ENSP00000707241
resolver
ensp
ENSP00000707242
resolver
ensp
ENSP00000707244
resolver
ensp
ENSP00000707246
resolver
ensp
ENSP00000757320
resolver
ensp
ENSP00000757321
resolver
ensp
ENSP00000757323
resolver
enst
ENST00000361059
resolver
enst
ENST00000394800
resolver
enst
ENST00000502499
resolver
enst
ENST00000502929
resolver
enst
ENST00000504203
resolver
enst
ENST00000910014
resolver
enst
ENST00000910016
resolver
enst
ENST00000910028
resolver
enst
ENST00000928206
resolver
enst
ENST00000928207
resolver
enst
ENST00000955717
resolver
genesymbol
MATR3
resolver
genesymbol_syn
KIAA0723
resolver
hgnc
HGNC:6912
resolver
uniprot
A0A0R4J2E8
resolver
uniprot
A8MXP9
resolver
uniprot
B3KM87
resolver
uniprot
B4DF66
resolver
uniprot
B7ZAV5
resolver
uniprot
D3DQC3
resolver
uniprot
F6SVW3
resolver
uniprot
Q9H4N1
resolver
uniprot
Q9UHW0
resolver
uniprot
Q9UQ27
resolver
uniprot_entry
A0A0R4J2E8_HUMAN
resolver
uniprot_entry
A8MXP9_HUMAN
resolver
uniprot_entry
B3KM87_HUMAN
resolver
uniprot_entry
B4DF66_HUMAN
resolver
uniprot_entry
F6SVW3_HUMAN
resolver
uniprot_entry
MATR3_HUMAN
resolver
uniprot_entry
Q9H4N1_HUMAN
resolver
uniprot_sec
B7ZAV5
resolver
uniprot_sec
D3DQC3
resolver
uniprot_sec
Q9UHW0
resolver
uniprot_sec
Q9UQ27
resolver
amino_acid_sequence
MSKSFQQSSLSRDSQGHGRDLSAAGIGLLAAATQSLSMPASLGRMNQGTARLASLMNLGMSSSLNQQGAHSALSSASTSSHNLQSIFNIGSRGPLPLSSQHRGDADQASNILASFGLSARDLDELSRYPEDKITPENLPQILLQLKRRRTEEGPTLSYGRDGRSATREPPYRVPRDDWEEKRHFRRDSFDDRGPSLNPVLDYDHGSRSQESGYYDRMDYEDDRLRDGERCRDDSFFGETSHNYHKFDSEYERMGRGPGPLQERSLFEKKRGAPPSSNIEDFHGLLPKGYPHLCSICDLPVHSNKEWSQHINGASHSRRCQLLLEIYPEWNPDNDTGHTMGDPFMLQQSTNPAPGILGPPPPSFHLGGPAVGPRGNLGAGNGNLQGPRHMQKGRVETSRVVHIMDFQRGKNLRYQLLQLVEPFGVISNHLILNKINEAFIEMATTEDAQAAVDYYTTTPALVFGKPVRVHLSQKYKRIKKPEGKPDQKFDQKQELGRVIHLSNLPHSGYSDSAVLKLAEPYGKIKNYILMRMKSQAFIEMETREDAMAMVDHCLKKALWFQGRCVKVDLSEKYKKLVLRIPNRGIDLLKKDKSRKRSYSPDGKESPSDKKSKTDGSQKTESSTEGKEQEEKSGEDGEKDTKDDQTEQEPNMLLESEDELLVDEEEAAALLESGSSVGDETDLANLGDVASDGKKEPSDKAVKKDGSASAAAKKKLKKVDKIEELDQENEAALENGIKNEENTEPGAESSENADDPNKDTSENADGQSDENKDDYTIPDEYRIGPYQPNVPVGIDYVIPKTGFYCKLCSLFYTNEEVAKNTHCSSLPHYQKLKKFLNKLAEERRQKKET
uniprot
proteins
disease_involvement
DISEASE: Amyotrophic lateral sclerosis 21 (ALS21) [MIM:606070]: A neurodegenerative disorder affecting upper and lower motor neurons, resulting in muscle weakness and respiratory failure. Some patients may develop myopathic features or dementia. {ECO:0000269|PubMed:19344878, ECO:0000269|PubMed:24686783, ECO:0000269|PubMed:25771394, ECO:0000269|PubMed:26199109}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}.
uniprot
proteins
mass_dalton
94623
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
11525732
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
17932509
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19131338
uniprot
proteins
pubmed
19344878
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
2033075
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24686783
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25771394
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26199109
uniprot
proteins
pubmed
27731383
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28431233
uniprot
proteins
pubmed
28712728
uniprot
proteins
pubmed
29476152
uniprot
proteins
pubmed
32245947
uniprot
proteins
pubmed
37548402
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
847
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus matrix.
uniprot
proteins