Rab5c
entrez
19345
canonical
uniprot
P35278
canonical
ensembl
ENSMUSG00000019173
resolver
ensp
ENSMUSP00000019317
resolver
ensp
ENSMUSP00000102987
resolver
ensp
ENSMUSP00000268135
resolver
enst
ENSMUST00000019317
resolver
enst
ENSMUST00000107364
resolver
genesymbol
Rab5c
resolver
genesymbol_syn
Rab5C
resolver
uniprot
F8WGW6
resolver
uniprot
Q3TJ39
resolver
uniprot
Q8C266
resolver
uniprot
Q8R1V8
resolver
uniprot
Q8R2N8
resolver
uniprot_entry
F8WGW6_MOUSE
resolver
uniprot_entry
Q3TJ39_MOUSE
resolver
uniprot_entry
Q8C266_MOUSE
resolver
uniprot_entry
RAB5C_MOUSE
resolver
uniprot_sec
Q8R1V8
resolver
uniprot_sec
Q8R2N8
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP (Probable). Regulated by GTPase activating proteins (GAPs) including SGSM3, which increase the GTP hydrolysis activity (By similarity). Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000250|UniProtKB:P51148, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MAGRGGAARPNGPAAGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNTDTFARAKNWVKELQRQASPNIVIALAGNKADLASKRAVEFQEAQAYADDNSLLFMETSAKTAMNVNEIFMAIAKKLPKNEPQNAAGAPGRTRGVDLQESNPASRSQCCSN
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in early endocytic trafficking. Required for EEA1 recruitment to early endosomes. Required for EGF and transferrin endocytosis and trafficking through early endosomes. {ECO:0000250|UniProtKB:P51148}.
uniprot
proteins
mass_dalton
23413
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-85 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2. {ECO:0000250|UniProtKB:P51148}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11278565
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1555775
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20339}; Lipid-anchor {ECO:0000250|UniProtKB:P20339}; Cytoplasmic side {ECO:0000250|UniProtKB:P20339}. Early endosome membrane {ECO:0000250|UniProtKB:P20339}; Lipid-anchor {ECO:0000250|UniProtKB:P20339}. Melanosome {ECO:0000250|UniProtKB:P51148}.
uniprot
proteins