PPIH
entrez
10465
canonical
uniprot
O43447
canonical
ensembl
ENSG00000171960
resolver
ensp
ENSP00000306614
resolver
ensp
ENSP00000503384
resolver
ensp
ENSP00000504195
resolver
genesymbol
PPIH
resolver
genesymbol_syn
CYP20
resolver
genesymbol_syn
CYPH
resolver
hgnc
HGNC:14651
resolver
uniprot
A6NNE7
resolver
uniprot
D3DPW5
resolver
uniprot
Q6FH36
resolver
uniprot_entry
PPIH_HUMAN
resolver
uniprot_entry
Q6FH36_HUMAN
resolver
uniprot_sec
A6NNE7
resolver
uniprot_sec
D3DPW5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by cyclosporin A. {ECO:0000305|PubMed:20676357}.
uniprot
proteins
amino_acid_sequence
MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM
uniprot
proteins
ec_number
5.2.1.8
uniprot
proteins
function
FUNCTION: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. {ECO:0000269|PubMed:11823439, ECO:0000269|PubMed:12875835, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:9570313}.
uniprot
proteins
mass_dalton
19208
uniprot
proteins
mutagenesis
MUTAGEN 133; /note="W->F: Abolishes inhibition by cyclosporin A."; /evidence="ECO:0000269|PubMed:11823439
uniprot
proteins
protein_family
Cyclophilin-type PPIase family
uniprot
proteins
protein_family
PPIase H subfamily
uniprot
proteins
pubmed
10713041
uniprot
proteins
pubmed
11823439
uniprot
proteins
pubmed
12875835
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16723661
uniprot
proteins
pubmed
20676357
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9404889
uniprot
proteins
pubmed
9570313
uniprot
proteins
sequence_length
177
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:9570313}. Cytoplasm {ECO:0000269|PubMed:9570313}. Note=Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic.
uniprot
proteins