MC3R
entrez
4159
canonical
uniprot
P41968
canonical
ensembl
ENSG00000124089
resolver
ensp
ENSP00000243911
resolver
enst
ENST00000243911
resolver
genesymbol
MC3R
resolver
hgnc
HGNC:6931
resolver
uniprot
Q4KN27
resolver
uniprot
Q9H517
resolver
uniprot_entry
MC3R_HUMAN
resolver
uniprot_sec
Q4KN27
resolver
uniprot_sec
Q9H517
resolver
amino_acid_sequence
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:37524700, PubMed:8463333). Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which contributes to the regulation of energy homeostasis (PubMed:18231126, PubMed:37524700, PubMed:8463333). Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain (By similarity). Binding of the Agouti-related protein/AGPR antagonist precludes alpha-MSH-induced signaling, blocking cAMP production (PubMed:9311920). {ECO:0000250|UniProtKB:P33033, ECO:0000269|PubMed:18231126, ECO:0000269|PubMed:37524700, ECO:0000269|PubMed:8463333, ECO:0000269|PubMed:9311920}.
uniprot
proteins
mass_dalton
36043
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="F->A: Over 100-fold decrease in gamma-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 94; /note="E->A: Loss of gamma-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 94; /note="E->Q: Decreased gamma-MSH-induced cAMP accumulation."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 98; /note="I->A: 10 to 100-fold decrease in gamma-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 113; /note="I->A: 2 to 10 fold decrease in gamma-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 117; /note="D->A: 10 to 100-fold decrease in gamma-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 117; /note="D->N: Decreased gamma-MSH-induced cAMP accumulation."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 121; /note="D->A: 10 to 100-fold decrease in gamma-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 121; /note="D->N: Loss of gamma-MSH-induced cAMP accumulation."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 180; /note="I->A: 10 to 100-fold decrease in gamma-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 189; /note="I->A: 2 to 10 fold decrease in gamma-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 192; /note="L->A: 2 to 10 fold decrease in gamma-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 258; /note="F->A: 10 to 100-fold decrease in gamma-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 261; /note="H->A: 10 to 100-fold decrease in gamma-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 265; /note="I->M: 3-fold decrease in gamma-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 265; /note="I->W: 18-fold decrease in gamma-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 265; /note="I->Y: 4-fold decrease in gamma-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 281; /note="F->A: 2 to 10 fold decrease in gamma-MSH potency."; /evidence="ECO:0000269|PubMed:37524700
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
11889220
uniprot
proteins
pubmed
15292330
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18231126
uniprot
proteins
pubmed
22433616
uniprot
proteins
pubmed
37524700
uniprot
proteins
pubmed
8463333
uniprot
proteins
pubmed
9311920
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 38..63; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 76..100; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 119..140; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 187..210; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 246..268; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 278..301; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins