Tmed2
entrez
65165
canonical
uniprot
Q63524
canonical
ensembl
ENSRNOG00000001053
resolver
ensembl
ENSRNOG00055002509
resolver
ensembl
ENSRNOG00055013725
resolver
ensembl
ENSRNOG00060002792
resolver
ensembl
ENSRNOG00065002135
resolver
ensembl
ENSRNOG00065006789
resolver
ensp
ENSRNOP00000001397
resolver
ensp
ENSRNOP00000077165
resolver
ensp
ENSRNOP00055003009
resolver
ensp
ENSRNOP00055019192
resolver
ensp
ENSRNOP00060003182
resolver
ensp
ENSRNOP00065001937
resolver
ensp
ENSRNOP00065007793
resolver
enst
ENSRNOT00000001397
resolver
enst
ENSRNOT00000105841
resolver
enst
ENSRNOT00055003987
resolver
enst
ENSRNOT00055023585
resolver
enst
ENSRNOT00060004488
resolver
enst
ENSRNOT00065002813
resolver
enst
ENSRNOT00065010572
resolver
genesymbol
Tmed2
resolver
genesymbol_syn
Rnp24
resolver
uniprot
A0A8I5Y5Z9
resolver
uniprot_entry
A0A8I5Y5Z9_RAT
resolver
uniprot_entry
TMED2_RAT
resolver
amino_acid_sequence
MVTLAELLVLLAALLATASGYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV
uniprot
proteins
function
FUNCTION: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing (By similarity). {ECO:0000250, ECO:0000269|PubMed:21219331}.
uniprot
proteins
mass_dalton
22733
uniprot
proteins
mutagenesis
MUTAGEN 200..201; /note="VV->AA: Localization at cell surface."; /evidence="ECO:0000269|PubMed:11739402
uniprot
proteins
protein_family
EMP24/GP25L family
uniprot
proteins
pubmed
10214941
uniprot
proteins
pubmed
11703931
uniprot
proteins
pubmed
11739402
uniprot
proteins
pubmed
11748249
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15718469
uniprot
proteins
pubmed
17693410
uniprot
proteins
pubmed
21219331
uniprot
proteins
pubmed
8663407
uniprot
proteins
pubmed
9472029
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:10214941, ECO:0000269|PubMed:15718469, ECO:0000269|PubMed:9472029}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10214941}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q15363}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10214941}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:10214941}; Single-pass type I membrane protein {ECO:0000255}. Note=Cycles between compartments of the early secretatory pathway. {ECO:0000269|PubMed:10214941}.
uniprot
proteins
transmembrane_region
TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins