SHLD3
entrez
112441434
canonical
uniprot
Q6ZNX1
canonical
ensembl
ENSG00000253251
resolver
ensp
ENSP00000424007
resolver
ensp
ENSP00000601161
resolver
enst
ENST00000510585
resolver
enst
ENST00000931102
resolver
genesymbol
SHLD3
resolver
genesymbol_syn
FLJ26957
resolver
genesymbol_syn
RINN1
resolver
hgnc
HGNC:53826
resolver
uniprot_entry
SHLD3_HUMAN
resolver
amino_acid_sequence
MTTEVILHYRPCESDPTQLPKIAEKAIQDFPTRPLSRFIPWFPYDGSKLPLRPKRSPPVISEEAAEDVKQYLTISEHDAKSHSYDCTVDLLEFQPSLKKQHLTWSHTLKEQTNSGNLGKQSEKGKQHKRRSWSISLPSNNCTKNVSPLSKKLQDSLKALNLHSLYRARWTIEHTICNSQTLEDIWTKLNQIIRHNELPSCNATIQRHLGQIWVFCDIMYCEYVGSLLKGRLALTGKINLFVHKYGVIFSM
uniprot
proteins
function
FUNCTION: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. {ECO:0000269|PubMed:29656893}.
uniprot
proteins
mass_dalton
28842
uniprot
proteins
mutagenesis
MUTAGEN 53..58; /note="PKRSPP->AKRSPA: Fails to interact with MAD2L2."; /evidence="ECO:0000269|PubMed:29656893
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
29656893
uniprot
proteins
pubmed
34354233
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:29656893}. Note=Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle. {ECO:0000269|PubMed:29656893}.
uniprot
proteins