Chmp3
entrez
282834
canonical
uniprot
Q8CGS4
canonical
ensembl
ENSRNOG00000007356
resolver
ensembl
ENSRNOG00055019915
resolver
ensembl
ENSRNOG00060014902
resolver
ensembl
ENSRNOG00065005188
resolver
ensp
ENSRNOP00000010253
resolver
ensp
ENSRNOP00000093828
resolver
ensp
ENSRNOP00055027632
resolver
ensp
ENSRNOP00060020326
resolver
ensp
ENSRNOP00065005288
resolver
enst
ENSRNOT00000010253
resolver
enst
ENSRNOT00055034018
resolver
enst
ENSRNOT00060025493
resolver
enst
ENSRNOT00065007623
resolver
genesymbol
Chmp3
resolver
genesymbol_syn
Vps24
resolver
uniprot_entry
CHMP3_RAT
resolver
amino_acid_sequence
MGLFGKTQEKPPKELVNEWSLKIRKEMRVVDRQIRDIQREEEKVKRSVKDAAKKGQKEVCVVLAKEMIRSRKAVSKLYASKAHMNSVLMGMKNQLAVLRVAGSLQKSTEVMKAMQSLVKIPEIQATMRELSKEMMKAGIIEEMLEDTFESMDDQEEMEEAAEMEIDRILFEITAGALGKAPSKVTDALPEPEPAGAMAASEGDEEDDEEDLEAMQSRLATLRS
uniprot
proteins
function
FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor (By similarity). {ECO:0000250, ECO:0000269|PubMed:12878588}.
uniprot
proteins
mass_dalton
25062
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="K->D: Strongly reduces binding to PtdIns(3,5)P2."; /evidence="ECO:0000269|PubMed:12878588
uniprot
proteins
protein_family
SNF7 family
uniprot
proteins
pubmed
12878588
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12878588}. Membrane {ECO:0000269|PubMed:12878588}; Lipid-anchor {ECO:0000269|PubMed:12878588}. Endosome {ECO:0000269|PubMed:12878588}. Late endosome membrane {ECO:0000250}. Note=Localizes to the midbody of dividing cells. {ECO:0000250}.
uniprot
proteins