NAGK
entrez
55577
canonical
uniprot
Q9UJ70
canonical
ensembl
ENSG00000124357
resolver
ensp
ENSP00000244204
resolver
ensp
ENSP00000396070
resolver
ensp
ENSP00000653742
resolver
enst
ENST00000418807
resolver
genesymbol
NAGK
resolver
hgnc
HGNC:17174
resolver
uniprot
A0A384N6G7
resolver
uniprot
B4DLZ5
resolver
uniprot
C9JEV6
resolver
uniprot
Q53HD5
resolver
uniprot
Q6IA84
resolver
uniprot
Q9BS29
resolver
uniprot
Q9BVP0
resolver
uniprot
Q9NV37
resolver
uniprot_entry
A0A384N6G7_HUMAN
resolver
uniprot_entry
C9JEV6_HUMAN
resolver
uniprot_entry
NAGK_HUMAN
resolver
uniprot_sec
B4DLZ5
resolver
uniprot_sec
Q53HD5
resolver
uniprot_sec
Q6IA84
resolver
uniprot_sec
Q9BS29
resolver
uniprot_sec
Q9BVP0
resolver
uniprot_sec
Q9NV37
resolver
amino_acid_sequence
MAAIYGGVEGGGTRSEVLLVSEDGKILAEADGLSTNHWLIGTDKCVERINEMVNRAKRKAGVDPLVPLRSLGLSLSGGDQEDAGRILIEELRDRFPYLSESYLITTDAAGSIATATPDGGVVLISGTGSNCRLINPDGSESGCGGWGHMMGDEGSAYWIAHQAVKIVFDSIDNLEAAPHDIGYVKQAMFHYFQVPDRLGILTHLYRDFDKCRFAGFCRKIAEGAQQGDPLSRYIFRKAGEMLGRHIVAVLPEIDPVLFQGKIGLPILCVGSVWKSWELLKEGFLLALTQGREIQAQNFFSSFTLMKLRHSSALGGASLGARHIGHLLPMDYSANAIAFYSYTFS
uniprot
proteins
ec_number
2.7.1.-
uniprot
proteins
ec_number
2.7.1.59
uniprot
proteins
ec_number
2.7.1.60
uniprot
proteins
function
FUNCTION: Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:22692205). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (PubMed:22692205). Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (PubMed:36002575). {ECO:0000250|UniProtKB:Q9QZ08, ECO:0000269|PubMed:22692205, ECO:0000269|PubMed:36002575}.
uniprot
proteins
mass_dalton
37376
uniprot
proteins
mutagenesis
MUTAGEN 107; /note="D->V: Abolished ability to phosphorylate muramyl dipeptide."; /evidence="ECO:0000269|PubMed:36002575
uniprot
proteins
pathway_participation
PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation. {ECO:0000269|PubMed:22692205}.
uniprot
proteins
protein_family
Eukaryotic-type N-acetylglucosamine kinase family
uniprot
proteins
pubmed
10824116
uniprot
proteins
pubmed
12112843
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17010375
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22692205
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
36002575
uniprot
proteins
sequence_length
344
uniprot
proteins