Mymx
entrez
653016
canonical
uniprot
Q2Q5T5
canonical
ensembl
ENSMUSG00000079471
resolver
ensp
ENSMUSP00000109157
resolver
ensp
ENSMUSP00000126690
resolver
ensp
ENSMUSP00000137630
resolver
ensp
ENSMUSP00000146823
resolver
genesymbol
Mymx
resolver
genesymbol_syn
Gm7325
resolver
genesymbol_syn
minion
resolver
uniprot
A0A223PZC0
resolver
uniprot
E9PXI1
resolver
uniprot_entry
A0A223PZC0_MOUSE
resolver
uniprot_entry
MYMX_MOUSE
resolver
uniprot_sec
E9PXI1
resolver
amino_acid_sequence
MPVPLLPMVLRSLLSRLLLPVARLARQHLLPLLRRLARRLSSQDMREALLSCLLFVLSQQQPPDSGEASRVDHSQRKERLGPQK
uniprot
proteins
function
FUNCTION: Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed:28386024, PubMed:28569745, PubMed:28569755, PubMed:30197239). Involved in membrane fusion downstream of the lipid mixing step mediated by MYMK (PubMed:30197239). Acts by generating membrane stresses via its extracellular C-terminus, leading to drive fusion pore formation (PubMed:30197239). Acts independently of MYMK (PubMed:30197239). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (PubMed:29581287). {ECO:0000269|PubMed:28386024, ECO:0000269|PubMed:28569745, ECO:0000269|PubMed:28569755, ECO:0000269|PubMed:29581287, ECO:0000269|PubMed:30197239}.
uniprot
proteins
mass_dalton
9598
uniprot
proteins
mutagenesis
MUTAGEN 34; /note="R->E: Decreased interaction with MYMK without affecting localization to the cell membrane."; /evidence="ECO:0000269|PubMed:28386024"; MUTAGEN 38; /note="R->E: Decreased interaction with MYMK without affecting localization to the cell membrane."; /evidence="ECO:0000269|PubMed:28386024"; MUTAGEN 46; /note="R->E: Decreased interaction with MYMK without affecting localization to the cell membrane."; /evidence="ECO:0000269|PubMed:28386024"; MUTAGEN 46; /note="Missing: Homozygous mice die perinatally due to muscle abnormalities."; /evidence="ECO:0000269|PubMed:35642635"; MUTAGEN 52; /note="C->A: Abolishes the ability to mediate myoblast fusion; does not affect interaction with MYMK; does not affect localization to the cell membrane."; /evidence="ECO:0000269|PubMed:28386024
uniprot
proteins
protein_family
MYMX family
uniprot
proteins
pubmed
16331322
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
28386024
uniprot
proteins
pubmed
28569745
uniprot
proteins
pubmed
28569755
uniprot
proteins
pubmed
29581287
uniprot
proteins
pubmed
30197239
uniprot
proteins
pubmed
35642635
uniprot
proteins
sequence_length
84
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28386024, ECO:0000269|PubMed:28569745, ECO:0000269|PubMed:28569755}; Single-pass membrane protein {ECO:0000269|PubMed:30197239}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins