Slc30a4
entrez
22785
canonical
uniprot
O35149
canonical
ensembl
ENSMUSG00000005802
resolver
ensp
ENSMUSP00000005952
resolver
ensp
ENSMUSP00000097056
resolver
enst
ENSMUST00000005952
resolver
enst
ENSMUST00000099457
resolver
genesymbol
Slc30a4
resolver
genesymbol_syn
Lm
resolver
genesymbol_syn
Znt4
resolver
uniprot
A2AK40
resolver
uniprot
O35154
resolver
uniprot
Q3UYZ9
resolver
uniprot_entry
A2AK40_MOUSE
resolver
uniprot_entry
ZNT4_MOUSE
resolver
uniprot_sec
O35154
resolver
uniprot_sec
Q3UYZ9
resolver
amino_acid_sequence
MAGPGAWKRLKSLLRKDDTPLFLNDTSAFDFSDEVSDEGLSRFNKLRVVVADDDSEAPERPVNGAHPALQADDDSLLDQDLPLTNSQLSLKMDPCDNCSKRRELLKQRKVKTRLTIAAVLYLLFMIGELVGGYMANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTRRFTFGFHRLEVLSAMISVMLVYVLMGFLLYEAVQRTIHMNYEINGDVMLITAAVGVAVNVIMGFLLNQSGHHHSHAHSHSLPSNSPSMVSSGHNHGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYKIADPICTYIFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKESLMKIEDVYSVEDLNIWSLTSGKSTAIVHMQLIPGSSSKWEEVQSKAKHLLLNTFGMYKCTIQLQSYRQEVIRTCANCHSSST
uniprot
proteins
disease_involvement
DISEASE: Note=Defect in Slc30a4 is the cause of the lethal milk (lm) phenotype. Mice with lm are defective in zinc transport into breast milk, due to a premature translation termination codon at position 297. Only homozygous mutant adults develop dermatitis, skin lesions, and hair loss due to a systemic zinc deficiency. Pups of any genotype suckled on homozygous mutant female also develop symptoms characteristic of nutritional zinc deficiency, including dermatitis, alopecia and stunted growth. {ECO:0000269|PubMed:9354792}.
uniprot
proteins
function
FUNCTION: Probable proton-coupled zinc ion antiporter mediating zinc import from cytoplasm potentially into the endocytic compartment (PubMed:9354792). Controls zinc deposition in milk (PubMed:9354792). {ECO:0000269|PubMed:9354792}.
uniprot
proteins
mass_dalton
47800
uniprot
proteins
protein_family
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
uniprot
proteins
protein_family
SLC30A subfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17101726
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9354792
uniprot
proteins
sequence_length
430
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:O55174}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:O14863}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:O14863}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:17101726}. Note=Enriched in vesicles within the basal region of epithelial cells (By similarity). Expressed in the cytoplasm in the epithelial cells in the large intestine (PubMed:17101726). {ECO:0000250|UniProtKB:O55174, ECO:0000269|PubMed:17101726}.
uniprot
proteins
transmembrane_region
TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 276..296; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 312..332; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins