Grin2c
entrez
14813
canonical
uniprot
Q01098
canonical
ensembl
ENSMUSG00000020734
resolver
ensp
ENSMUSP00000003351
resolver
ensp
ENSMUSP00000102164
resolver
ensp
ENSMUSP00000223688
resolver
ensp
ENSMUSP00000223696
resolver
ensp
ENSMUSP00000223700
resolver
ensp
ENSMUSP00000223711
resolver
ensp
ENSMUSP00000223716
resolver
enst
ENSMUST00000003351
resolver
enst
ENSMUST00000106554
resolver
genesymbol
Grin2c
resolver
uniprot
A2A6S2
resolver
uniprot_entry
A2A6S2_MOUSE
resolver
uniprot_entry
NMDE3_MOUSE
resolver
amino_acid_sequence
MGGALGPALLLTSLLGAWAGLGAGQGEQAVTVAVVFGSSGPLQAQARTRLTPQNFLDLPLEIQPLTIGVNNTNPSSILTQICGLLGAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASYLSWRLLDVLTLELGPGGPRARTQRLLRQVDAPVLVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPAAFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYRRQYGTLPAPAGDCRSHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRWDHGVLYMKYPVWPRYSTSLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDITPYTKLCCKGFCIDILKKLAKVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTKGKKSGGPSFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICHNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPSSSQLDFLLAFSRGIYSCFNGVQSLPSPARPPSPDLTAGSAQANVLKMLQAARDMVSTADVSGSLDRATRTIENWGNNRRAPAPTTSGPRSCTPGPPGQPSPSGWRPPGGGRTPLARRAPQPPARPATCAGSPQPDVSRASCRHAWDARWPVRVGHQGSHLSASERRALPERSLLHAHCHYSSFPRAERSGRPFLPLFPEPPEPDDLPLLGPEQLARREALLRAAWARGPRPRHASLPSSVAEAFTRSNPLPARCTGHACACPCPQSRPSCRHVAQTQSLRLPSYREACVEGVPAGVAATWQPRQHVCLHTHTHLPFCWGTVCRHPPPCSSHSPWLIGTWEPPSHRGRTLGLGTGYRDSGVLEEVSREACGTQGFPRSCTWRRISSLESEV
uniprot
proteins
function
FUNCTION: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:1377365). Participates in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current and long-term synaptic potentiation (PubMed:8987814). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1377365, PubMed:7790891). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:1377365). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex (PubMed:27922130). {ECO:0000250|UniProtKB:P35438, ECO:0000269|PubMed:1377365, ECO:0000269|PubMed:27922130, ECO:0000269|PubMed:7790891, ECO:0000269|PubMed:8987814}.
uniprot
proteins
mass_dalton
135420
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
protein_family
NR2C/GRIN2C subfamily
uniprot
proteins
pubmed
1377365
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27922130
uniprot
proteins
pubmed
7790891
uniprot
proteins
pubmed
8987814
uniprot
proteins
sequence_length
1239
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1377365}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 555..575; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q14957"; TRANSMEM 627..644; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q14957"; TRANSMEM 814..836; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q14957
uniprot
proteins