Pak4
entrez
70584
canonical
uniprot
Q8BTW9
canonical
ensembl
ENSMUSG00000030602
resolver
ensp
ENSMUSP00000032823
resolver
ensp
ENSMUSP00000103918
resolver
enst
ENSMUST00000032823
resolver
enst
ENSMUST00000108283
resolver
genesymbol
Pak4
resolver
genesymbol_syn
Kiaa1142
resolver
uniprot
Q6ZPX0
resolver
uniprot
Q80Z97
resolver
uniprot
Q9CS71
resolver
uniprot_entry
PAK4_MOUSE
resolver
uniprot_sec
Q6ZPX0
resolver
uniprot_sec
Q80Z97
resolver
uniprot_sec
Q9CS71
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by INKA1; which inhibits the serine/threonine-protein kinase activity by binding PAK4 in a substrate-like manner. {ECO:0000250|UniProtKB:O96013}.
uniprot
proteins
amino_acid_sequence
MFGKKKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLIDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRESPPPPARAHQENGMLEERAAPARMAPDKAGSRARATGHSEAGSGSGDRRRVGPEKRPKSSRDGPGGPQEASRDKRPLSGPDVSTPQPGSLTSGTKLAAGRPFNTYPRADTDHPPRGAQGEPHTMAPNGPSATGLAAPQSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPARALAAPAVPPAPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFLTKAGPPASIVPLMRQHRTR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (By similarity). {ECO:0000250|UniProtKB:O96013, ECO:0000269|PubMed:11413130, ECO:0000269|PubMed:21381077}.
uniprot
proteins
mass_dalton
64623
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on serine residues when activated by CDC42/p21 (By similarity). Phosphorylated on tyrosine residues upon stimulation of FGFR2 (PubMed:12529371). Methylated by SETD6. {ECO:0000250|UniProtKB:O96013, ECO:0000269|PubMed:12529371}.; PTM: Polyubiquitinated, leading to its proteasomal degradation. {ECO:0000250|UniProtKB:O96013}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
11413130
uniprot
proteins
pubmed
12529371
uniprot
proteins
pubmed
14517283
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21381077
uniprot
proteins
pubmed
21382368
uniprot
proteins
sequence_length
593
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O96013}. Note=Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways. {ECO:0000250|UniProtKB:O96013}.
uniprot
proteins