GPR83
entrez
10888
canonical
uniprot
Q9NYM4
canonical
ensembl
ENSG00000123901
resolver
ensp
ENSP00000243673
resolver
ensp
ENSP00000441550
resolver
genesymbol
GPR83
resolver
genesymbol_syn
GPR72
resolver
genesymbol_syn
JP05
resolver
genesymbol_syn
KIAA1540
resolver
hgnc
HGNC:4523
resolver
uniprot
B0M0K5
resolver
uniprot
F5GZ43
resolver
uniprot
Q6NWR4
resolver
uniprot
Q9P1Y8
resolver
uniprot_entry
GPR83_HUMAN
resolver
uniprot_sec
B0M0K5
resolver
uniprot_sec
F5GZ43
resolver
uniprot_sec
Q6NWR4
resolver
uniprot_sec
Q9P1Y8
resolver
amino_acid_sequence
MVPHLLLLCLLPLVRATEPHEGRADEQSAEAALAVPNASHFFSWNNYTFSDWQNFVGRRRYGAESQNPTVKALLIVAYSFIIVFSLFGNVLVCHVIFKNQRMHSATSLFIVNLAVADIMITLLNTPFTLVRFVNSTWIFGKGMCHVSRFAQYCSLHVSALTLTAIAVDRHQVIMHPLKPRISITKGVIYIAVIWTMATFFSLPHAICQKLFTFKYSEDIVRSLCLPDFPEPADLFWKYLDLATFILLYILPLLIISVAYARVAKKLWLCNMIGDVTTEQYFALRRKKKKTIKMLMLVVVLFALCWFPLNCYVLLLSSKVIRTNNALYFAFHWFAMSSTCYNPFIYCWLNENFRIELKALLSMCQRPPKPQEDRPPSPVPSFRVAWTEKNDGQRAPLANNLLPTSQLQSGKTDLSSVEPIVTMS
uniprot
proteins
function
FUNCTION: G protein-coupled peptide receptor (PubMed:27117253, PubMed:37689599). Several peptides, PEN, derived from the proSAAS precursor (encoded by PCSK1N), the procholecystokinin-derived peptide proCCK56-63, and the related proteins FAM237A and FAM237B have been reported to activate GPR83 through GNAI1/G(i) and GNAS/G(s)-mediated signaling pathways (PubMed:27117253, PubMed:32713278, PubMed:36853120, PubMed:37689599). However, due to conflicting evidence about the ability of these peptides to bind to and activate the GPR83, the endogenous ligand of GPR83 still remains uncertain (PubMed:36853120, PubMed:37894796). Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors (By similarity). {ECO:0000250|UniProtKB:P30731, ECO:0000269|PubMed:27117253, ECO:0000269|PubMed:32713278, ECO:0000269|PubMed:36853120, ECO:0000269|PubMed:37689599, ECO:0000269|PubMed:37894796}.
uniprot
proteins
mass_dalton
48339
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10760605
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
11720708
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
27117253
uniprot
proteins
pubmed
32713278
uniprot
proteins
pubmed
36853120
uniprot
proteins
pubmed
37689599
uniprot
proteins
pubmed
37894796
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P30731}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with GPR171 in the paraventricular nucleus. Colocalizes with the ghrelin receptor GHSR1A in the hypothalamus. {ECO:0000250|UniProtKB:P30731}.
uniprot
proteins
transmembrane_region
TRANSMEM 72..92; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 108..129; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 146..167; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 187..208; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 239..260; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 294..315; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 328..348; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins