M0R3K6
uniprot
M0R3K6
canonical
amino_acid_sequence
MARAGPEYREWNSELIKPKKLLNPVKASRSHQELHRELLMNHKRGLGMDRKPELQRVLEHRRRNQLIKKKEEELEAKRMQCPFEQELLRRQQRLNQLENPPQREEDHAPEFIKVRENLRRITTLTSEERAL
uniprot
proteins
function
FUNCTION: Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development (By similarity). {ECO:0000250|UniProtKB:O95990, ECO:0000250|UniProtKB:Q78TU8}.
uniprot
proteins
mass_dalton
15930
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
21969592
uniprot
proteins
sequence_length
131
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95990}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:O95990}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:O95990}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O95990}. Synapse {ECO:0000250|UniProtKB:Q78TU8}. Cell projection {ECO:0000269|PubMed:21969592}. Note=Colocalizes with F-actin and COMMD1 in the nucleus. Colocalizes with MAP1A along actin stress fibers and membrane ruffles. {ECO:0000250|UniProtKB:O95990}.
uniprot
proteins