ADAM2
entrez
2515
canonical
uniprot
Q99965
canonical
ensembl
ENSG00000104755
resolver
ensembl
ENSG00000276286
resolver
ensp
ENSP00000265708
resolver
ensp
ENSP00000343854
resolver
ensp
ENSP00000369182
resolver
ensp
ENSP00000429352
resolver
ensp
ENSP00000478636
resolver
ensp
ENSP00000480574
resolver
ensp
ENSP00000488853
resolver
enst
ENST00000379853
resolver
enst
ENST00000521880
resolver
enst
ENST00000611998
resolver
enst
ENST00000619491
resolver
enst
ENST00000633755
resolver
genesymbol
ADAM2
resolver
genesymbol_syn
FTNB
resolver
hgnc
HGNC:198
resolver
uniprot
A0A0G2JM69
resolver
uniprot
A0A0G2JN33
resolver
uniprot
B4DWY7
resolver
uniprot
P78326
resolver
uniprot
Q6P2G0
resolver
uniprot
Q9UQQ8
resolver
uniprot_entry
A0A0G2JM69_HUMAN
resolver
uniprot_entry
A0A0G2JN33_HUMAN
resolver
uniprot_entry
ADAM2_HUMAN
resolver
uniprot_entry
B4DWY7_HUMAN
resolver
uniprot_entry
Q6P2G0_HUMAN
resolver
uniprot_sec
P78326
resolver
uniprot_sec
Q9UQQ8
resolver
amino_acid_sequence
MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNLMQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG
uniprot
proteins
function
FUNCTION: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
uniprot
proteins
mass_dalton
82457
uniprot
proteins
post_translational_modification
PTM: The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8702389
uniprot
proteins
pubmed
9041139
uniprot
proteins
pubmed
9070941
uniprot
proteins
sequence_length
735
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 687..707; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins