GPD1
entrez
2819
canonical
uniprot
P21695
canonical
ensembl
ENSG00000167588
resolver
ensp
ENSP00000301149
resolver
ensp
ENSP00000446768
resolver
genesymbol
GPD1
resolver
hgnc
HGNC:4455
resolver
uniprot
A0A024R138
resolver
uniprot
F8W1L5
resolver
uniprot
Q8N1B0
resolver
uniprot_entry
A0A024R138_HUMAN
resolver
uniprot_entry
GPDA_HUMAN
resolver
uniprot_sec
F8W1L5
resolver
uniprot_sec
Q8N1B0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by zinc ions and sulfate. {ECO:0000269|PubMed:16460752}.
uniprot
proteins
amino_acid_sequence
MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAAEDADILIFVVPHQFIGKICDQLKGHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGPETARELYSILQHKGLVDKFPLFMAVYKVCYEGQPVGEFIHCLQNHPEHM
uniprot
proteins
disease_involvement
DISEASE: Hypertriglyceridemia, transient infantile (HTGTI) [MIM:614480]: An autosomal recessive disorder characterized by onset of moderate to severe transient hypertriglyceridemia in infancy that normalizes with age. The hypertriglyceridemia is associated with hepatomegaly, moderately elevated transaminases, persistent fatty liver, and the development of hepatic fibrosis. {ECO:0000269|PubMed:22226083, ECO:0000269|PubMed:24549054}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.1.1.8
uniprot
proteins
function
FUNCTION: Has glycerol-3-phosphate dehydrogenase activity. {ECO:0000269|PubMed:7772607}.
uniprot
proteins
mass_dalton
37568
uniprot
proteins
protein_family
NAD-dependent glycerol-3-phosphate dehydrogenase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16460752
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22226083
uniprot
proteins
pubmed
2398890
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24549054
uniprot
proteins
pubmed
7772607
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7772607}.
uniprot
proteins