Tmem168
entrez
101118
canonical
uniprot
Q91VX9
canonical
ensembl
ENSMUSG00000029569
resolver
ensp
ENSMUSP00000031554
resolver
ensp
ENSMUSP00000344057
resolver
enst
ENSMUST00000031554
resolver
genesymbol
Tmem168
resolver
uniprot
Q3TDA5
resolver
uniprot_entry
TM168_MOUSE
resolver
uniprot_sec
Q3TDA5
resolver
amino_acid_sequence
MCRSLRYCVSHCLYLAMTRLEEVNREVNMHSSVRYLGYLARINLLVAICLGLYVRWEKTANSLILVIFILGLFVLGIASILYYYFSMEAASLSLSNLWFGFLLGLLCFLDNSSFKSDVKEETTKYLLLTSIVLRILCALVERISGYVRHRPTLLTTVEFLELVGFAIASTTMLVEKSLSVILLVMALAMLIIDLRMKSFLAIPNLIIFSVLLFFSSLETPQNPIAFACFFICLVTDPFLDIYFSGLSVTERWKPFLHRGRICRRLSVLFTAMIELTFFILSAFKLRDTHLWYFVIPGFSIFGFFWMICHIIFLLTLWGFHTKLNDCHKVYINHRADNNSLDRIMASKGMRHFCLISEQLVFFSLLATAILGAVSWQPTNGIFLSMFLIVLPLESMAHGLFHELGNCLGGTSVGYAIVIPTNFCSPDGQPTLLPPEHVQELNLRSTGMLNAIQRFFAYHMIETYGCDYSTSGLSFDTLHSKLKAFLELRTVDGPRHDTYVLYYSGHTHGSGEWALAGGDILRLDTLLEWWREKNGSFCSRLIIILDSENSTPWVKEVRKINDQYVAVQGAELAKTVDIEEADPPQLGDFTRDWVEYNCNSTNNICWTEKGRTVRAVYGVSKRWSDYTLHLPTGSDVAKHWMLHFPRVTYPLVHLANWLCGLNLFWVCKACFRCLKRLKMSWFLPTVLDTGQGFKLVKS
uniprot
proteins
function
FUNCTION: Plays a key role in maintaining the cardiac electrical stability by modulating cell surface expression of SCN5A (PubMed:32175648). Plays a role i the modulation of anxiety behavior by regulating GABAergic neuronal system in the nucleus accumbens (PubMed:29211814). {ECO:0000269|PubMed:29211814, ECO:0000269|PubMed:32175648}.
uniprot
proteins
mass_dalton
79674
uniprot
proteins
protein_family
TMEM168 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29211814
uniprot
proteins
pubmed
32175648
uniprot
proteins
sequence_length
697
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:32175648}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 63..83; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 89..109; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 199..219; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 223..243; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 352..372; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 380..400; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins