ANPEP
entrez
290
canonical
uniprot
P15144
canonical
ensembl
ENSG00000166825
resolver
ensp
ENSP00000300060
resolver
ensp
ENSP00000452934
resolver
ensp
ENSP00000453413
resolver
ensp
ENSP00000502886
resolver
ensp
ENSP00000559353
resolver
ensp
ENSP00000559354
resolver
ensp
ENSP00000559355
resolver
ensp
ENSP00000559356
resolver
ensp
ENSP00000559358
resolver
ensp
ENSP00000640366
resolver
enst
ENST00000300060
resolver
enst
ENST00000559874
resolver
enst
ENST00000560137
resolver
enst
ENST00000679248
resolver
enst
ENST00000889294
resolver
enst
ENST00000889295
resolver
enst
ENST00000889296
resolver
enst
ENST00000889297
resolver
enst
ENST00000970307
resolver
genesymbol
ANPEP
resolver
genesymbol_syn
APN
resolver
genesymbol_syn
CD13
resolver
genesymbol_syn
PEPN
resolver
hgnc
HGNC:500
resolver
uniprot
Q16728
resolver
uniprot
Q59E93
resolver
uniprot
Q6GT90
resolver
uniprot
Q8IUK3
resolver
uniprot
Q8IVH3
resolver
uniprot
Q9UCE0
resolver
uniprot_entry
AMPN_HUMAN
resolver
uniprot_entry
Q59E93_HUMAN
resolver
uniprot_sec
Q16728
resolver
uniprot_sec
Q6GT90
resolver
uniprot_sec
Q8IUK3
resolver
uniprot_sec
Q8IVH3
resolver
uniprot_sec
Q9UCE0
resolver
amino_acid_sequence
MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQWFTENSK
uniprot
proteins
ec_number
3.4.11.2
uniprot
proteins
function
FUNCTION: Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity). {ECO:0000250|UniProtKB:P97449, ECO:0000269|PubMed:10605003, ECO:0000269|PubMed:10676659, ECO:0000269|PubMed:11384645, ECO:0000269|PubMed:12473585, ECO:0000269|PubMed:7576235, ECO:0000269|PubMed:8102610, ECO:0000269|PubMed:9056417}.; FUNCTION: (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. {ECO:0000269|PubMed:12551991, ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485, ECO:0000269|PubMed:9367365}.; FUNCTION: (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection. {ECO:0000269|PubMed:8105105}.
uniprot
proteins
mass_dalton
109540
uniprot
proteins
mutagenesis
MUTAGEN 288..295; /note="DYVEKQAS->QSVEETAQ: No change in receptor activity and HCoV-229E infection."; /evidence="ECO:0000269|PubMed:11559807"; MUTAGEN 288..295; /note="DYVEKQAS->QSVNEQAQ: No change in receptor activity and HCoV-229E infection."; /evidence="ECO:0000269|PubMed:11559807"; MUTAGEN 288..295; /note="DYVEKQAS->QSVNETAQ: Complete loss of receptor activity and blocks HCoV-229E infection. No loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:11559807"; MUTAGEN 291..293; /note="EKQ->NKT: Complete loss of receptor activity and blocks HCoV-229E infection. No loss of enzymatic activity."; MUTAGEN 291; /note="E->N: No change of receptor activity and HCoV-229E infection."; MUTAGEN 293; /note="Q->T: No change of receptor activity and HCoV-229E infection."; MUTAGEN 392; /note="H->A: Loss of aminopeptidase activity."; /evidence="ECO:0000269|PubMed:8887485"; MUTAGEN 818; /note="N->E: Very low receptor activity and HCoV-229E infection."; /evidence="ECO:0000269|PubMed:11559807
uniprot
proteins
post_translational_modification
PTM: Sulfated. {ECO:0000250|UniProtKB:P15145}.; PTM: N- and O-glycosylated. {ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:1705556, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22932899, ECO:0000269|PubMed:9056417}.; PTM: May undergo proteolysis and give rise to a soluble form. {ECO:0000269|PubMed:7902291}.
uniprot
proteins
protein_family
Peptidase M1 family
uniprot
proteins
pubmed
10605003
uniprot
proteins
pubmed
10676659
uniprot
proteins
pubmed
11384645
uniprot
proteins
pubmed
11559807
uniprot
proteins
pubmed
12473585
uniprot
proteins
pubmed
12551991
uniprot
proteins
pubmed
1350662
uniprot
proteins
pubmed
15084671
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
1675638
uniprot
proteins
pubmed
1705556
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22932899
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2564851
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2901990
uniprot
proteins
pubmed
6149934
uniprot
proteins
pubmed
7576235
uniprot
proteins
pubmed
7902291
uniprot
proteins
pubmed
8102610
uniprot
proteins
pubmed
8105105
uniprot
proteins
pubmed
8887485
uniprot
proteins
pubmed
9056417
uniprot
proteins
pubmed
9367365
uniprot
proteins
pubmed
9452074
uniprot
proteins
sequence_length
967
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2564851, ECO:0000269|PubMed:9056417}; Single-pass type II membrane protein {ECO:0000305|PubMed:1350662}. Note=Also found as a soluble form. {ECO:0000269|PubMed:7902291}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..32; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins