Slx1b
entrez
75764
canonical
uniprot
Q8BX32
canonical
ensembl
ENSMUSG00000059772
resolver
ensp
ENSMUSP00000118182
resolver
genesymbol
Slx1b
resolver
genesymbol_syn
Giyd1
resolver
genesymbol_syn
Giyd2
resolver
genesymbol_syn
Gm6939
resolver
genesymbol_syn
Slx1
resolver
uniprot
Q3TQB5
resolver
uniprot
Q9D609
resolver
uniprot_entry
Q3TQB5_MOUSE
resolver
uniprot_entry
SLX1_MOUSE
resolver
uniprot_sec
Q9D609
resolver
amino_acid_sequence
MDHAARPGRFFGVYLLYCQNPRHRGRVYVGFTVNPARRVRQHNAGRKKGGAWRTSGRGPWDMVLIIHGFPSAVAALRFEWAWQHPQASRRLTHVGPRLRSEAAFAFHLRVLAHMLRVPPWVRLPLTLRWLRPDFRHELCPAPPAHMPIAFGPPPPQPLVPKRPAVSEADSERQLDLGTKARCSLCARLLQDEEGPLCCPHPGCPLRAHIICLAEEFLQEEPGQLLPLEGHCPSCKKSLLWGNLVGQCHADTEEEEDLELEEEHWTDLLET
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. {ECO:0000255|HAMAP-Rule:MF_03100}.
uniprot
proteins
mass_dalton
30656
uniprot
proteins
protein_family
SLX1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
27010503
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03100}.
uniprot
proteins