Ecrg4
entrez
78896
canonical
uniprot
Q99LS0
canonical
ensembl
ENSMUSG00000026051
resolver
ensp
ENSMUSP00000027217
resolver
enst
ENSMUST00000027217
resolver
genesymbol
Ecrg4
resolver
uniprot
Q9D2U7
resolver
uniprot_entry
AUGN_MOUSE
resolver
uniprot_sec
Q9D2U7
resolver
amino_acid_sequence
MSTSSARPAVLALAGLALLLLLCLGPDGISGNKLKKMLQKREGPVPSKTNVAVAENTAKEFLGGLKRAKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDVNYWLNRNRNGHDYYGDYYQRHYDEDAAIGPHSRESFRHGASVNYNDY
uniprot
proteins
function
FUNCTION: Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (PubMed:20404145). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (PubMed:20404145). {ECO:0000269|PubMed:20404145}.
uniprot
proteins
mass_dalton
16992
uniprot
proteins
protein_family
Augurin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17284679
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20404145
uniprot
proteins
pubmed
21349154
uniprot
proteins
sequence_length
148
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17284679, ECO:0000269|PubMed:20404145}. Cytoplasm {ECO:0000250|UniProtKB:Q9H1Z8}. Apical cell membrane {ECO:0000250|UniProtKB:Q9H1Z8}.
uniprot
proteins