RBPMS2
entrez
348093
canonical
uniprot
Q6ZRY4
canonical
ensembl
ENSG00000166831
resolver
ensp
ENSP00000300069
resolver
genesymbol
RBPMS2
resolver
hgnc
HGNC:19098
resolver
uniprot
A2RRG0
resolver
uniprot_entry
RBPS2_HUMAN
resolver
uniprot_sec
A2RRG0
resolver
amino_acid_sequence
MSNLKPDGEHGGSTGTGSGAGSGGALEEEVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLIKLTARQPVGFVIFDSRAGAEAAKNALNGIRFDPENPQTLRLEFAKANTKMAKSKLMATPNPSNVHPALGAHFIARDPYDLMGAALIPASPEAWAPYPLYTTELTPAISHAAFTYPTATAAAAALHAQVRWYPSSDTTQQGWKYRQFC
uniprot
proteins
function
FUNCTION: RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (PubMed:25064856). Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (By similarity). Acts as a pre-mRNA alternative splicing regulator (By similarity). Mediates ACTN1 and FLNB alternative splicing (By similarity). Likely binds to mRNA tandem CAC trinucleotide or CA dinucleotide motifs (PubMed:24860013). {ECO:0000250|UniProtKB:B5DFF2, ECO:0000250|UniProtKB:Q9W6I1, ECO:0000269|PubMed:24860013, ECO:0000269|PubMed:25064856}.
uniprot
proteins
mass_dalton
22497
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="L->E: Strongly reduces homodimerization and interaction with EEF2. Strongly reduces NOG mRNA binding. Loss of function in gastrointestinal smooth muscle cell differentiation."; /evidence="ECO:0000269|PubMed:25064856"; MUTAGEN 49; /note="L->Q: No effect on homodimerization. No effect on function in gastrointestinal smooth muscle cell differentiation."; /evidence="ECO:0000269|PubMed:25064856
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
24860013
uniprot
proteins
pubmed
25064856
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24860013, ECO:0000269|PubMed:25064856}. Nucleus {ECO:0000269|PubMed:24860013}. Cytoplasm, Stress granule {ECO:0000269|PubMed:24860013}. Note=Localized to cytoplasmic stress granules after oxidative stress. {ECO:0000269|PubMed:24860013}.
uniprot
proteins