Rtp4
entrez
67775
canonical
uniprot
Q9ER80
canonical
ensembl
ENSMUSG00000033355
resolver
ensp
ENSMUSP00000041091
resolver
ensp
ENSMUSP00000147442
resolver
ensp
ENSMUSP00000147521
resolver
enst
ENSMUST00000038423
resolver
enst
ENSMUST00000209422
resolver
enst
ENSMUST00000210901
resolver
genesymbol
Rtp4
resolver
genesymbol_syn
Ifrg28
resolver
uniprot
Q9D3D6
resolver
uniprot_entry
RTP4_MOUSE
resolver
uniprot_sec
Q9D3D6
resolver
amino_acid_sequence
MLFPDDFSTWEQTFQELMQEEKPGAKWSLHLDKNIVPDGAALGWRQHQQTVLGRFQCSRCCRSWTSAQVMILCHMYPDTLKSQGQARMRIFGQKCQKCFGCQFETPKFSTEIIKRILNNLVNYILQRYYGHRKIALTSNASLGEKVTLDGPHDTRNCEACSLNSHGRCALAHKVKPPRSPSPLPKSSSPSKSCPPPPQTRNTDFGNKTFQDFGNRTFQGCREPPQREIEPPLFLFLSIAAFALFSLFTR
uniprot
proteins
function
FUNCTION: Chaperone protein that facilitates the trafficking and functional cell surface expression of some G protein-coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (By similarity). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (PubMed:18836069). In addition, acts as a potent IFN-inducible suppressor of pathogens including lyssavirus rabies, influenza A or yellow fever virus (By similarity). Mechanistically, associates with the viral replicase, binds viral RNA, and thereby suppresses viral genome amplification that replicates at the endoplasmic reticulum (PubMed:38941768). In addition, restores antiviral signaling by interacting with and sequestering influenza virus protein NS1 (By similarity). {ECO:0000250|UniProtKB:Q96DX8, ECO:0000269|PubMed:18836069, ECO:0000269|PubMed:38941768}.
uniprot
proteins
mass_dalton
28392
uniprot
proteins
mutagenesis
MUTAGEN 57; /note="C->S: Almost no change in rabies lyssavirus viral genomic RNA binding."; /evidence="ECO:0000269|PubMed:38941768"; MUTAGEN 95; /note="C->S: Complete loss of rabies lyssavirus viral genomic RNA binding."; /evidence="ECO:0000269|PubMed:38941768"; MUTAGEN 157; /note="C->S: Almost no change in rabies lyssavirus viral genomic RNA binding."; /evidence="ECO:0000269|PubMed:38941768
uniprot
proteins
protein_family
TMEM7 family
uniprot
proteins
pubmed
15550249
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18836069
uniprot
proteins
pubmed
38941768
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q96DX8}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:Q96DX8}. Cytoplasm {ECO:0000250|UniProtKB:Q96DX8}.
uniprot
proteins
transmembrane_region
TRANSMEM 228..248; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins