ISYNA1
entrez
51477
canonical
uniprot
Q9NPH2
canonical
ensembl
ENSG00000105655
resolver
ensp
ENSP00000337746
resolver
ensp
ENSP00000415458
resolver
ensp
ENSP00000475677
resolver
genesymbol
ISYNA1
resolver
genesymbol_syn
INO1
resolver
hgnc
HGNC:29821
resolver
uniprot
A0A140VK73
resolver
uniprot
B3KRT1
resolver
uniprot
G5E9U0
resolver
uniprot
Q6NXT5
resolver
uniprot
Q7Z525
resolver
uniprot
Q9BT65
resolver
uniprot
Q9H2Y2
resolver
uniprot
Q9NSU0
resolver
uniprot
Q9NVW7
resolver
uniprot_entry
A0A140VK73_HUMAN
resolver
uniprot_entry
INO1_HUMAN
resolver
uniprot_sec
B3KRT1
resolver
uniprot_sec
G5E9U0
resolver
uniprot_sec
Q6NXT5
resolver
uniprot_sec
Q7Z525
resolver
uniprot_sec
Q9BT65
resolver
uniprot_sec
Q9H2Y2
resolver
uniprot_sec
Q9NSU0
resolver
uniprot_sec
Q9NVW7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by mood-stabilizing drugs such as valproate (VPA) and lithium. {ECO:0000269|PubMed:17901568, ECO:0000269|PubMed:17988368}.
uniprot
proteins
amino_acid_sequence
MEAAAQFFVESPDVVYGPEAIEAQYEYRTTRVSREGGVLKVHPTSTRFTFRTARQVPRLGVMLVGWGGNNGSTLTAAVLANRLRLSWPTRSGRKEANYYGSLTQAGTVSLGLDAEGQEVFVPFSAVLPMVAPNDLVFDGWDISSLNLAEAMRRAKVLDWGLQEQLWPHMEALRPRPSVYIPEFIAANQSARADNLIPGSRAQQLEQIRRDIRDFRSSAGLDKVIVLWTANTERFCEVIPGLNDTAENLLRTIELGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELAWQHRVFVGGDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGENLSAPLQFRSKEVSKSNVVDDMVQSNPVLYTPGEEPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLALLTELCQRVSFCTDMDPEPQTFHPVLSLLSFLFKAPLVPPGSPVVNALFRQRSCIENILRACVGLPPQNHMLLEHKMERPGPSLKRVGPVAATYPMLNKKGPVPAATNGCTGDANGHLQEEPPMPTT
uniprot
proteins
ec_number
5.5.1.4
uniprot
proteins
function
FUNCTION: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:15024000, PubMed:23902760). Rate-limiting enzyme in the synthesis of all inositol-containing compounds (PubMed:15024000). {ECO:0000269|PubMed:15024000, ECO:0000269|PubMed:23902760}.
uniprot
proteins
mass_dalton
61068
uniprot
proteins
mutagenesis
MUTAGEN 177; /note="S->A,D: Decreases activity."; /evidence="ECO:0000269|PubMed:23902760"; MUTAGEN 279; /note="S->A,D: Decreases activity."; /evidence="ECO:0000269|PubMed:23902760"; MUTAGEN 357; /note="S->D: Decreases activity."; /evidence="ECO:0000269|PubMed:23902760
uniprot
proteins
pathway_participation
PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-279 and Ser-357 may be associated with a decrease in activity. {ECO:0000269|PubMed:23902760}.
uniprot
proteins
protein_family
Myo-inositol 1-phosphate synthase family
uniprot
proteins
pubmed
12941308
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15024000
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15464731
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17121280
uniprot
proteins
pubmed
17901568
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
17988368
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23902760
uniprot
proteins
sequence_length
558
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P11986}.
uniprot
proteins