Tmem174
entrez
68344
canonical
uniprot
Q9DCX7
canonical
ensembl
ENSMUSG00000046082
resolver
ensp
ENSMUSP00000057581
resolver
enst
ENSMUST00000050389
resolver
genesymbol
Tmem174
resolver
uniprot
Q96LY0
resolver
uniprot_entry
TM174_MOUSE
resolver
uniprot_sec
Q96LY0
resolver
amino_acid_sequence
MEHSSNRPEDFPLNVFSVTPYTPSTADIQVSDDDKAGATLLFSGIFLGLVGITFTVMGWIKYQGVSHFEWTQLLGPILLSVGVTFILIAVCKFKMLSCQLCSDNEERVPDSDQTSGGQSFVFTGINQPITFHGATVVQYIPPPYGSQEPLGMNATYLQPMMNPCGLIPPSGAAAAAPSPPQYYTIYPQDNAAFVESEGFSPFVGTGYDRPDSDADQLEGTELEEEDCVCFSPPPYEEIYALPR
uniprot
proteins
function
FUNCTION: Regulator of plasma phosphate homeostasis. Decreases serum inorganic phosphate (Pi) uptake by regulating the sodium-phosphate cotransporter SLC34A1 trafficking by PTH and FGF23 in the kidney. {ECO:0000269|PubMed:35428804, ECO:0000269|PubMed:35459732}.
uniprot
proteins
mass_dalton
26449
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
35428804
uniprot
proteins
pubmed
35459732
uniprot
proteins
sequence_length
243
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8WUU8}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:35428804}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with SLC34A1 in the plasma membrane of renal proximal tubule cells. {ECO:0000269|PubMed:35459732}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 73..93; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins