Myod1
entrez
17927
canonical
uniprot
P10085
canonical
ensembl
ENSMUSG00000009471
resolver
ensp
ENSMUSP00000072330
resolver
enst
ENSMUST00000072514
resolver
genesymbol
Myod1
resolver
genesymbol_syn
Myod
resolver
uniprot
Q8C6B1
resolver
uniprot_entry
MYOD1_MOUSE
resolver
uniprot_sec
Q8C6B1
resolver
amino_acid_sequence
MELLSPPLRDIDLTGPDGSLCSFETADDFYDDPCFDSPDLRFFEDLDPRLVHMGALLKPEEHAHFPTAVHPGPGAREDEHVRAPSGHHQAGRCLLWACKACKRKTTNADRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLRDQDAAPPGAAAFYAPGPLPPGRGSEHYSGDSDASSPRSNCSDGMMDYSGPPSGPRRQNGYDTAYYSEAARESRPGKSAAVSSLDCLSSIVERISTDSPAAPALLLADAPPESPPGPPEGASLSDTEQGTQTPSPDAAPQCPAGSNPNAIYQVL
uniprot
proteins
function
FUNCTION: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation (PubMed:16901893). Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (PubMed:21798092, PubMed:3175662). {ECO:0000269|PubMed:16901893, ECO:0000269|PubMed:21798092, ECO:0000269|PubMed:3175662}.
uniprot
proteins
mass_dalton
34233
uniprot
proteins
post_translational_modification
PTM: Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function. {ECO:0000269|PubMed:9029156}.; PTM: Ubiquitinated on the N-terminus; which is required for proteasomal degradation. {ECO:0000250}.; PTM: Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation (By similarity). {ECO:0000250}.; PTM: Methylation at Lys-104 by EHMT2/G9a inhibits myogenic activity. {ECO:0000250}.
uniprot
proteins
pubmed
11532390
uniprot
proteins
pubmed
12037670
uniprot
proteins
pubmed
12887892
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16901893
uniprot
proteins
pubmed
17011493
uniprot
proteins
pubmed
1754380
uniprot
proteins
pubmed
19723804
uniprot
proteins
pubmed
20124407
uniprot
proteins
pubmed
21798092
uniprot
proteins
pubmed
21832073
uniprot
proteins
pubmed
22569126
uniprot
proteins
pubmed
3175662
uniprot
proteins
pubmed
3286015
uniprot
proteins
pubmed
3690668
uniprot
proteins
pubmed
8181063
uniprot
proteins
pubmed
9029156
uniprot
proteins
pubmed
9343420
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16901893}.
uniprot
proteins