DCX
entrez
1641
canonical
uniprot
O43602
canonical
ensembl
ENSG00000077279
resolver
ensp
ENSP00000348553
resolver
ensp
ENSP00000350776
resolver
ensp
ENSP00000361061
resolver
ensp
ENSP00000419861
resolver
ensp
ENSP00000489635
resolver
ensp
ENSP00000490357
resolver
ensp
ENSP00000490614
resolver
ensp
ENSP00000490878
resolver
ensp
ENSP00000505501
resolver
ensp
ENSP00000632158
resolver
ensp
ENSP00000774371
resolver
ensp
ENSP00000774372
resolver
enst
ENST00000356220
resolver
enst
ENST00000371993
resolver
enst
ENST00000636035
resolver
enst
ENST00000637453
resolver
enst
ENST00000637570
resolver
enst
ENST00000680476
resolver
enst
ENST00000962099
resolver
genesymbol
DCX
resolver
genesymbol_syn
DBCN
resolver
genesymbol_syn
LISX
resolver
hgnc
HGNC:2714
resolver
uniprot
A0A1B0GWD1
resolver
uniprot
A0A1C7CYW0
resolver
uniprot
A0A7P0T9C5
resolver
uniprot
A0A804CF28
resolver
uniprot
A6NFY6
resolver
uniprot
A8K340
resolver
uniprot
A9Z1V8
resolver
uniprot
D3DUY8
resolver
uniprot
D3DUY9
resolver
uniprot
D3DUZ0
resolver
uniprot
O43911
resolver
uniprot
Q5JYZ5
resolver
uniprot_entry
A0A1B0GWD1_HUMAN
resolver
uniprot_entry
A0A1C7CYW0_HUMAN
resolver
uniprot_entry
A0A7P0T9C5_HUMAN
resolver
uniprot_entry
A0A804CF28_HUMAN
resolver
uniprot_entry
A8K340_HUMAN
resolver
uniprot_entry
DCX_HUMAN
resolver
uniprot_sec
A6NFY6
resolver
uniprot_sec
A9Z1V8
resolver
uniprot_sec
D3DUY8
resolver
uniprot_sec
D3DUY9
resolver
uniprot_sec
D3DUZ0
resolver
uniprot_sec
O43911
resolver
uniprot_sec
Q5JYZ5
resolver
amino_acid_sequence
MELDFGHFDERDKTSRNMRGSRMNGLPSPTHSAHCSFYRTRTLQALSNEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQSLASSNSAQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSATAGPKASPTPQKTSAKSPGPMRRSKSPADSGNDQDANGTSSSQLSTPKSKQSPISTPTSPGSLRKHKDLYLPLSLDDSDSLGDSM
uniprot
proteins
disease_involvement
DISEASE: Lissencephaly, X-linked 1 (LISX1) [MIM:300067]: A classic lissencephaly characterized by intellectual disability and seizures that are more severe in male patients. Affected boys show an abnormally thick cortex with absent or severely reduced gyri. Clinical manifestations include feeding problems, abnormal muscular tone, seizures and severe to profound psychomotor retardation. Female patients display a less severe phenotype referred to as 'doublecortex'. {ECO:0000269|PubMed:11468322, ECO:0000269|PubMed:12552055, ECO:0000269|PubMed:27292316, ECO:0000269|PubMed:9489699, ECO:0000269|PubMed:9489700, ECO:0000269|PubMed:9668176, ECO:0000269|PubMed:9817918}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Subcortical band heterotopia X-linked (SBHX) [MIM:300067]: SBHX is a mild brain malformation of the lissencephaly spectrum. It is characterized by bilateral and symmetric plates or bands of gray matter found in the central white matter between the cortex and cerebral ventricles, cerebral convolutions usually appearing normal. {ECO:0000269|PubMed:10369164, ECO:0000269|PubMed:10441340, ECO:0000269|PubMed:10807542, ECO:0000269|PubMed:11175293, ECO:0000269|PubMed:11601509, ECO:0000269|PubMed:12390976, ECO:0000269|PubMed:9618162, ECO:0000269|PubMed:9989615}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=A chromosomal aberration involving DCX is found in lissencephaly. Translocation t(X;2)(q22.3;p25.1).
uniprot
proteins
function
FUNCTION: Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. {ECO:0000269|PubMed:22359282}.
uniprot
proteins
mass_dalton
40574
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by MARK1, MARK2 and PKA regulates its ability to bind microtubules (By similarity). Phosphorylation at Ser-265 and Ser-297 seems to occur only in neonatal brain, the levels falling precipitously by postnatal day 21 (By similarity). {ECO:0000250|UniProtKB:O88809, ECO:0000250|UniProtKB:Q9ESI7}.; PTM: Ubiquitinated by MDM2, leading to its degradation by the proteasome. Ubiquitinated by MDM2 and subsequent degradation leads to reduce the dendritic spine density of olfactory bulb granule cells. {ECO:0000250|UniProtKB:O88809}.
uniprot
proteins
pubmed
10369164
uniprot
proteins
pubmed
10441340
uniprot
proteins
pubmed
10807542
uniprot
proteins
pubmed
11175293
uniprot
proteins
pubmed
11468322
uniprot
proteins
pubmed
11601509
uniprot
proteins
pubmed
12027577
uniprot
proteins
pubmed
12390976
uniprot
proteins
pubmed
12552055
uniprot
proteins
pubmed
12692530
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
22359282
uniprot
proteins
pubmed
24607389
uniprot
proteins
pubmed
27292316
uniprot
proteins
pubmed
9489699
uniprot
proteins
pubmed
9489700
uniprot
proteins
pubmed
9618162
uniprot
proteins
pubmed
9668176
uniprot
proteins
pubmed
9817918
uniprot
proteins
pubmed
9989615
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q9ESI7}. Note=Localizes at neurite tips. {ECO:0000250|UniProtKB:Q9ESI7}.
uniprot
proteins