Pard3
entrez
81918
canonical
uniprot
Q9Z340
canonical
ensembl
ENSRNOG00000032437
resolver
ensembl
ENSRNOG00055005278
resolver
ensembl
ENSRNOG00060005209
resolver
ensembl
ENSRNOG00065019347
resolver
ensp
ENSRNOP00000048964
resolver
ensp
ENSRNOP00000075058
resolver
ensp
ENSRNOP00000079670
resolver
ensp
ENSRNOP00000092087
resolver
ensp
ENSRNOP00000097873
resolver
enst
ENSRNOT00000105322
resolver
enst
ENSRNOT00000109223
resolver
enst
ENSRNOT00000111522
resolver
genesymbol
Pard3
resolver
genesymbol_syn
Par3
resolver
uniprot
A0A8I5ZN95
resolver
uniprot
A0A8I6AGY4
resolver
uniprot
A0A8I6GMQ2
resolver
uniprot_entry
A0A8I5ZN95_RAT
resolver
uniprot_entry
A0A8I6AGY4_RAT
resolver
uniprot_entry
A0A8I6GMQ2_RAT
resolver
uniprot_entry
PARD3_RAT
resolver
amino_acid_sequence
MKVTVCFGRTRVVVPCGDGRMKVFSLIQQAVTRYRKAVAKDPNYWIQVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFRPYQTTSEIEVTPSVLRANMPLHVRRSSDPALTGLSTSVSDNNFSSEEPSRKNPTRWSTTAGFLKQNTTGSPKTCDRKKDENYRSLPRDPSSWSNQFQRDNARSSLSASHPMVDRWLEKQEQDEEGTEEDSSRVEPVGHADTGLENMPNFSLDDMVKLVQVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEQENLFHENDCIVRINDGDLRNRRFEQAQHMFRQAMRARVIWFHVVPAANKEQYEQLSQREMNNYSPGRFSPDSHCVANRSVANNAPQALPRAPRLSQPPEQLDAHPRLPHSAHASTKPPTAPALAPPNVLSTSVGSVYNTKRVGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTKMEGTVSLLVFRQEEAFHPREMNAEPSQMQSPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKANQEAMETLRRSMSTEGNKRGMIQLIVARRISRCNELRSPGSPAAPELPIETELDDRERRISHSLYSGIEGLDESPTRNAALSRIMGESGKCQLSPTVNMPHDDTVMIEDDRLPVLPPHLSDQSSSSSHDDVGFIMTEAGTWAKATISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSNASQLDFVKTRKSKSMDLGIADETKLNTVDDQRAGSPNRDVGPSLGLKKSSSLESLQTAVAEVTLNGNIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPMVDDDDEGMETLEEDTEESSRSGRESVSTSSDQPSYSLERQMNGDPEKRDKAEKKKDKAGKDKKKDREKEKDKLKAKKGMLKGLGDMFRFGKHRKDDKMEKMGRIKIQDSFTSEEDRVRMKEEQERIQAKTREFRERQARERDYAEIQDFHRTFGCDDELLYGGMSSYDGCLALNARPQSPREGHLMDTLYAQVKKPRSSKPGDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQSWSSSRPASQSGRHSVSVEVQVQRQRQEERESFQQAQRQYSSLPRQSRKNASSVSQDSWEQNYAPGEGFQSAKENPRYSSYQGSRNGYLGGHGFNARVMLETQELLRQEQRRKEQQLKKQPPADGVRGPFRQDVPPSPSQVARLNRLQTPEKGRPFYS
uniprot
proteins
function
FUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:18550519). Seems to play a central role in the formation of epithelial tight junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination (PubMed:21949390). Targets the phosphatase PTEN to cell junctions (PubMed:18082612). {ECO:0000250|UniProtKB:Q8TEW0, ECO:0000250|UniProtKB:Q99NH2, ECO:0000269|PubMed:18082612, ECO:0000269|PubMed:18550519, ECO:0000269|PubMed:21949390}.
uniprot
proteins
mass_dalton
149448
uniprot
proteins
mutagenesis
MUTAGEN 458; /note="K->E: Reduces binding to membranes containing phosphoinositol lipids by half. Abolishes binding to membranes containing phosphoinositol lipids; when associated with E-546."; /evidence="ECO:0000269|PubMed:18082612"; MUTAGEN 491; /note="K->A: Slightly reduced binding to membranes containing phosphoinositol lipids."; /evidence="ECO:0000269|PubMed:18082612"; MUTAGEN 491; /note="K->E: Strongly reduced binding to membranes containing phosphoinositol lipids."; /evidence="ECO:0000269|PubMed:18082612"; MUTAGEN 504; /note="R->A: Slightly reduced binding to membranes containing phosphoinositol lipids; when associated with A-506."; /evidence="ECO:0000269|PubMed:18082612"; MUTAGEN 504; /note="R->E: Abolishes binding to membranes containing phosphoinositol lipids; when associated with E-506."; /evidence="ECO:0000269|PubMed:18082612"; MUTAGEN 506; /note="K->A: Slightly reduced binding to membranes containing phosphoinositol lipids; when associated with A-504."; /evidence="ECO:0000269|PubMed:18082612"; MUTAGEN 506; /note="K->E: Abolishes binding to membranes containing phosphoinositol lipids; when associated with E-504."; /evidence="ECO:0000269|PubMed:18082612"; MUTAGEN 532; /note="R->A: Reduces binding to membranes containing phosphoinositol lipids by half; when associated with A-535."; /evidence="ECO:0000269|PubMed:18082612"; MUTAGEN 532; /note="R->E: Almost abolished binding to membranes containing phosphoinositol lipids; when associated with E-535."; /evidence="ECO:0000269|PubMed:18082612"; MUTAGEN 535; /note="K->A: Reduces binding to membranes containing phosphoinositol lipids by half; when associated with A-532."; /evidence="ECO:0000269|PubMed:18082612"; MUTAGEN 535; /note="K->E: Almost abolished binding to membranes containing phosphoinositol lipids; when associated with E-532."; /evidence="ECO:0000269|PubMed:18082612"; MUTAGEN 546; /note="R->E: Abolishes binding to membranes containing phosphoinositol lipids; when associated with E-458."; /evidence="ECO:0000269|PubMed:18082612"; MUTAGEN 827; /note="S->E: Abolishes binding to PKCI."; /evidence="ECO:0000269|PubMed:22579248"; MUTAGEN 829; /note="S->A: No detectable impact on binding to PKCI."; /evidence="ECO:0000269|PubMed:22579248"; MUTAGEN 829; /note="S->E: Abolishes binding to PKCI."; /evidence="ECO:0000269|PubMed:22579248
uniprot
proteins
post_translational_modification
PTM: Acetylated. Deacetylated by SIRT2, thereby inhibiting Schwann cell peripheral myelination. {ECO:0000269|PubMed:21949390}.; PTM: Phosphorylation at Ser-827 by PRKCZ and PRKCI occurs at the most apical tip of epithelial cell-cell contacts during the initial phase of tight junction formation and may promote dissociation of the complex with PARD6. EGF-induced Tyr-1127 phosphorylation mediates dissociation from LIMK2 (By similarity). Phosphorylation by AURKA at Ser-962 is required for the normal establishment of neuronal polarity (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
PAR3 family
uniprot
proteins
pubmed
12045219
uniprot
proteins
pubmed
17476308
uniprot
proteins
pubmed
18082612
uniprot
proteins
pubmed
18550519
uniprot
proteins
pubmed
21949390
uniprot
proteins
pubmed
22579248
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9763423
uniprot
proteins
sequence_length
1337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endomembrane system. Cell junction. Cell junction, tight junction {ECO:0000250|UniProtKB:Q99NH2}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q99NH2}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. Colocalized with SIRT2 in internode region of myelin sheath (By similarity). {ECO:0000250}.
uniprot
proteins