Elp6
entrez
72341
canonical
uniprot
Q8BK75
canonical
ensembl
ENSMUSG00000054836
resolver
ensp
ENSMUSP00000142823
resolver
genesymbol
Elp6
resolver
genesymbol_syn
Tmem103
resolver
uniprot
Q9D0M9
resolver
uniprot_entry
ELP6_MOUSE
resolver
uniprot_sec
Q9D0M9
resolver
amino_acid_sequence
MFPELNNLLSTTPDKTEQGTLTLLCDAKTDGSFLVHHFLSFYLKANCKVCFVALVQSFSHYNIVGQKLGVSLTAARDRGQLVFLEGLKSSVEVLFHSQDEPHPLQFLREAGTGNLQSLYTFIQDTLKPADSEESPWKYPVLLVDNLSVLLSLGVGAVAVLDFMQYCRATVCCELKGNVVALVHDTEGATDEGNDTLLNGLSHQSHLILRAEGLATGFCKDVHGQLSILWRRPSRSTAQRAQSLTYQYKIQDKNVSFFAKGMSPAVL
uniprot
proteins
function
FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in cell migration (PubMed:22854966). {ECO:0000250|UniProtKB:Q0PNE2, ECO:0000269|PubMed:22854966}.
uniprot
proteins
mass_dalton
29327
uniprot
proteins
mutagenesis
MUTAGEN 126; /note="L->Q: In wobbly mutant; destabilization of the elongator complex and reduced tRNA wobble base modification leading to protein misfolding and aggregation in Purkinje neurons (PN), PN degeneration, microgliosis triggered by the NLPR3 inflammasome and an ataxia-like phenotype."; /evidence="ECO:0000269|PubMed:30097576
uniprot
proteins
pathway_participation
PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. {ECO:0000250|UniProtKB:Q0PNE2}.
uniprot
proteins
protein_family
ELP6 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22854966
uniprot
proteins
pubmed
30097576
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q0PNE2}. Nucleus {ECO:0000250|UniProtKB:Q0PNE2}. Note=Concentrates in the nucleus upon insulin stimulation. {ECO:0000250|UniProtKB:Q0PNE2}.
uniprot
proteins