Steep1
entrez
77644
canonical
uniprot
Q8VDP2
canonical
ensembl
ENSMUSG00000006423
resolver
ensp
ENSMUSP00000110903
resolver
ensp
ENSMUSP00000290618
resolver
genesymbol
Steep1
resolver
uniprot
A2A3V4
resolver
uniprot
Q3URC0
resolver
uniprot
Q8C8Z1
resolver
uniprot
Q9CWC1
resolver
uniprot_entry
STEEP_MOUSE
resolver
uniprot_sec
A2A3V4
resolver
uniprot_sec
Q3URC0
resolver
uniprot_sec
Q8C8Z1
resolver
uniprot_sec
Q9CWC1
resolver
amino_acid_sequence
MPKVVSRSVVCSDTRDREEYDDGEKPLHVYYCLCGQMVLVLDCQLEKLPMRPRDRSRVIDAAKHAHKFCNTEDEETTYLRRPEGIERQYRKKCAKCGLPLFYQSQPKNAPVTFIVDGAVVKFGQGFGKTNIYTQKQEPPKKVMMTKRTKDMGKFSSVTVSTIDEEEEEIEAREVADSYAQNAKVIEKQLERKGMSKRRLQELAELEAKKAKMKGTLIDNQFK
uniprot
proteins
function
FUNCTION: Molecular adapter that stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (By similarity). Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers (PubMed:32690950). {ECO:0000250|UniProtKB:Q9H5V9, ECO:0000269|PubMed:32690950}.
uniprot
proteins
mass_dalton
25594
uniprot
proteins
protein_family
STEEP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29374277
uniprot
proteins
pubmed
32690950
uniprot
proteins
pubmed
32929276
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29374277}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9H5V9}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H5V9}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H5V9}. Nucleus {ECO:0000269|PubMed:29374277}. Note=Recruited to the endoplasmic reticulum following interaction with phosphorylated STING1 (By similarity). Detected in the nucleus and cell soma of pyramidal neurons in the brain cortex and Purkinje cells, as well as in neurons in the granular layer in the cerebellum (PubMed:29374277). {ECO:0000250|UniProtKB:Q9H5V9, ECO:0000269|PubMed:29374277}.
uniprot
proteins