KIR2DS5
entrez
3810
canonical
uniprot
Q14953
canonical
ensembl
ENSG00000274739
resolver
ensembl
ENSG00000275047
resolver
ensembl
ENSG00000277650
resolver
ensembl
ENSG00000284217
resolver
ensembl
ENSG00000288206
resolver
ensembl
ENSG00000288357
resolver
ensp
ENSP00000482547
resolver
ensp
ENSP00000483733
resolver
ensp
ENSP00000484843
resolver
ensp
ENSP00000492015
resolver
ensp
ENSP00000492235
resolver
ensp
ENSP00000492394
resolver
ensp
ENSP00000493745
resolver
ensp
ENSP00000496107
resolver
ensp
ENSP00000496607
resolver
enst
ENST00000614053
resolver
enst
ENST00000618443
resolver
enst
ENST00000619698
resolver
enst
ENST00000638690
resolver
enst
ENST00000639440
resolver
enst
ENST00000639571
resolver
enst
ENST00000643495
resolver
enst
ENST00000644792
resolver
enst
ENST00000645738
resolver
genesymbol
KIR2DS5
resolver
genesymbol_syn
CD158G
resolver
genesymbol_syn
NKAT9
resolver
hgnc
HGNC:6337
resolver
uniprot
A0A0C4ZMZ1
resolver
uniprot_entry
KI2S5_HUMAN
resolver
uniprot_sec
A0A0C4ZMZ1
resolver
amino_acid_sequence
MSLMVISMACVAFFLLQGAWPHEGFRRKPSLLAHPGPLVKSEETVILQCWSDVMFEHFLLHREGTFNHTLRLIGEHIDGVSKGNFSIGRMTQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHERRLPAGPKVNRTFQADFPLDPATHGGTYRCFGSFRDSPYEWSKSSDPLLVSVTGNSSNSWPSPTEPSSETGNPRHLHVLIGTSVVKLPFTILLFFLLHRWCSNKKNASVMDQGPAGNRTVNREDSDEQDHQEVSYA
uniprot
proteins
function
FUNCTION: Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity (PubMed:18624290, PubMed:18682925, PubMed:28685972). Able to activate NK cells citotoxicity and cytokine production such as IFNG (PubMed:18624290, PubMed:24269691). Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 represented in this entry (PubMed:28685972). {ECO:0000269|PubMed:18624290, ECO:0000269|PubMed:18682925, ECO:0000269|PubMed:24269691, ECO:0000269|PubMed:28685972}.
uniprot
proteins
mass_dalton
33698
uniprot
proteins
mutagenesis
MUTAGEN 68; /note="H->D: Increases expression at the cell surface."; /evidence="ECO:0000269|PubMed:18682925"; MUTAGEN 68; /note="H->L: Reduces expression at the cell surface."; /evidence="ECO:0000269|PubMed:18682925
uniprot
proteins
post_translational_modification
PTM: N-glycosylated, glycosylation varies depending on the allele which alters cell surface expression levels. {ECO:0000269|PubMed:18682925, ECO:0000269|PubMed:24269691}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
18624290
uniprot
proteins
pubmed
18682925
uniprot
proteins
pubmed
24269691
uniprot
proteins
pubmed
28569259
uniprot
proteins
pubmed
28685972
uniprot
proteins
pubmed
8662091
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18624290, ECO:0000269|PubMed:18682925, ECO:0000269|PubMed:24269691}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000269|PubMed:18682925, ECO:0000269|PubMed:24269691}.
uniprot
proteins
transmembrane_region
TRANSMEM 246..264; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins