Shisa7
entrez
232813
canonical
uniprot
Q8C3Q5
canonical
ensembl
ENSMUSG00000053550
resolver
ensp
ENSMUSP00000064886
resolver
ensp
ENSMUSP00000112423
resolver
ensp
ENSMUSP00000210577
resolver
ensp
ENSMUSP00000210579
resolver
ensp
ENSMUSP00000210581
resolver
genesymbol
Shisa7
resolver
uniprot
A0A172Q401
resolver
uniprot
A0A172Q418
resolver
uniprot
Q3UMB3
resolver
uniprot_entry
SHSA7_MOUSE
resolver
uniprot_sec
A0A172Q401
resolver
uniprot_sec
A0A172Q418
resolver
uniprot_sec
Q3UMB3
resolver
amino_acid_sequence
MPALLLLGTVALLASAAGPAGARPSNDTSSVAPGPLPALLAHLRRLTGALAGGGSAAGTSANATKTSPASGTGAAARAPPPAELCHGYYDVMGQYDATFNCSTGSYRFCCGTCHYRFCCEHRHMRLAQASCSNYDTPRWATTPPPLAGGAGGAGGAGGGPGPGQAGWLEGGRAGGAGGRGGEGPGGSTAYVVCGVISFALAVGVGAKVAFSKASRAPRAHREINVPRALVDILRHQAGPATRPDRARSSSLTPGLGGPDSMAPRTPKNLYNTMKPSNLDNLHYNVNSPKHHAATLDWRAMPPPSPSLHYSTLSCSRSFHNLSHLPPSYEAAVKSELNRYSSLKRLAEKDLDEAYLKRRQLEMPRGTLPLHALRRPGTGGGYRMDGWGGPEELGLAPAPNPRRVMSQEHLLGDGSRASRYEFTLPRARLVSQEHLLLSSPEALRQSREHLLSPPRSPALPPDPTTRASLAASHSNLLLGPGGPPTPLHGLPPSGLHAHHHHALHGSPQPAWMSDAGGGGGTLARRPPFQRQGTLEQLQFIPGHHLPQHLRTASKNEVTV
uniprot
proteins
function
FUNCTION: Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain (PubMed:31601770). Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain (PubMed:31601770). May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall (Probable). May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses (Probable). {ECO:0000269|PubMed:31601770, ECO:0000305|PubMed:26623514, ECO:0000305|PubMed:29199957}.
uniprot
proteins
mass_dalton
58334
uniprot
proteins
mutagenesis
MUTAGEN 154..175; /note="Missing: Abolishes the colocalization with GPHN."; /evidence="ECO:0000269|PubMed:31601770"; MUTAGEN 555..558; /note="Missing: Loss of interaction with PDZ-domain of DLG4."; /evidence="ECO:0000269|PubMed:29199957
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:29199957}.
uniprot
proteins
protein_family
Shisa family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26623514
uniprot
proteins
pubmed
29199957
uniprot
proteins
pubmed
31601770
uniprot
proteins
sequence_length
558
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic density membrane {ECO:0000269|PubMed:29199957, ECO:0000269|PubMed:31601770}; Single-pass type I membrane protein {ECO:0000305|PubMed:29199957}. Note=Localizes at GABAergic inhibitory synapses and colocalizes with gephyrin in hippocampal neurons. {ECO:0000269|PubMed:31601770}.
uniprot
proteins
transmembrane_region
TRANSMEM 190..210; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins