Q9JIA3
uniprot
Q9JIA3
canonical
amino_acid_sequence
MAGVACLGKTADADEWCDSGLGSLGPDAAAPGGPGLVAELSPELSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYLDLQNDLGQTALHLAAILGEASTVEKLYAAGAGVLVTERGGHTALHLACRVRAHTCAYVLLQPRPSHPRDASDTYLTQSQDHTPDTSHAPVATDPQPNPGNEEELRDEDWRLQLEAENYDGHTPLHVAVIHKDAEMVQLLRDAGADLNKPEPTCGRTPLHLAVEGQAAGVLALLLKAGADPTARMYGGRTPLGSALLRPNPVLARLLRAHGAPEPEDKDDKLSPCSNSSSDSDSDNRDEGDEYDDIVVHSRRSQNQPPPSPAAKPLPDDPNPA
uniprot
proteins
function
FUNCTION: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
uniprot
proteins
mass_dalton
38081
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
NF-kappa-B inhibitor family
uniprot
proteins
pubmed
10827092
uniprot
proteins
pubmed
16822942
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins