SLC25A35
entrez
399512
canonical
uniprot
Q3KQZ1
canonical
ensembl
ENSG00000125434
resolver
ensp
ENSP00000369407
resolver
ensp
ENSP00000462395
resolver
ensp
ENSP00000464071
resolver
ensp
ENSP00000464231
resolver
ensp
ENSP00000464307
resolver
ensp
ENSP00000549513
resolver
ensp
ENSP00000609454
resolver
ensp
ENSP00000720755
resolver
ensp
ENSP00000720756
resolver
genesymbol
SLC25A35
resolver
hgnc
HGNC:31921
resolver
uniprot
Q494X5
resolver
uniprot
Q6RGS3
resolver
uniprot
Q8N7Y5
resolver
uniprot_entry
S2535_HUMAN
resolver
uniprot_sec
Q494X5
resolver
uniprot_sec
Q6RGS3
resolver
uniprot_sec
Q8N7Y5
resolver
amino_acid_sequence
MDFLMSGLAACGACVFTNPLEVVKTRMQLQGELQAPGTYQRHYRNVFHAFITIGKVDGLAALQKGLAPALLYQFLMNGIRLGTYGLAEAGGYLHTAEGTHSPARSAAAGAMAGVMGAYLGSPIYMVKTHLQAQAASEIAVGHQYKHQGMFQALTEIGQKHGLVGLWRGALGGLPRVIVGSSTQLCTFSSTKDLLSQWEIFPPQSWKLALVAAMMSGIAVVLAMAPFDVACTRLYNQPTDAQGKGLMYRGILDALLQTARTEGIFGMYKGIGASYFRLGPHTILSLFFWDQLRSLYYTDTK
uniprot
proteins
function
FUNCTION: Mediates phosphoenolpyruvate (PEP) efflux across the inner membrane of mitochondria as part of glyceroneogenesis pathway in the liver and adipose tissue. Transports PEP generated via the mitochondrial PC- and PCK2-dependent pyruvate-to-PEP bypass, thereby driving PEP flux required for cytosolic glycerol 3-phosphate and triglyceride synthesis. Controls INS-induced glycerolipid synthesis in adipocytes (By similarity). Most likely operates as an antiporter that exchanges monocarboxylates such as PEP and possibly dicarboxylates and sulfur oxoanions across the inner membrane of mitochondria. PEP transport is gated by mitochondrial membrane potential, although the precise transport mechanism has yet to be fully elucidated (By similarity) (PubMed:18682385). {ECO:0000250|UniProtKB:Q5SWT3, ECO:0000269|PubMed:18682385}.
uniprot
proteins
mass_dalton
32438
uniprot
proteins
pathway_participation
PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis. {ECO:0000250|UniProtKB:Q5SWT3}.
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16949250
uniprot
proteins
pubmed
18682385
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q5SWT3}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 59..79; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 91..119; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 169..190; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 205..225; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 277..300; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins