Etf1
entrez
225363
canonical
uniprot
Q8BWY3
canonical
ensembl
ENSMUSG00000024360
resolver
ensp
ENSMUSP00000025218
resolver
enst
ENSMUST00000025218
resolver
genesymbol
Etf1
resolver
uniprot
Q3TF02
resolver
uniprot
Q3TPZ6
resolver
uniprot
Q91VH9
resolver
uniprot_entry
ERF1_MOUSE
resolver
uniprot_entry
Q3TF02_MOUSE
resolver
uniprot_sec
Q3TPZ6
resolver
uniprot_sec
Q91VH9
resolver
amino_acid_sequence
MADDPSAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTASNIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGKEKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGTLQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVAETAVQLFISGDKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLKALEMGAVEILIVYENLDIMRYVLHCQGTEEEKILYLTPEQEKDKSHFTDKETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKSQEGSQFVKGFGGIGGILRYRVDFQGMEYQGGDDEFFDLDDY
uniprot
proteins
function
FUNCTION: Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons. The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA. Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site, followed by hydrolysis of peptidyl-tRNA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. {ECO:0000250|UniProtKB:P62495}.
uniprot
proteins
mass_dalton
49031
uniprot
proteins
post_translational_modification
PTM: Hydroxylation at Lys-63 by JMJD4 promotes its translational termination efficiency. {ECO:0000305|PubMed:24486019}.; PTM: Methylated at Gln-185 by N6AMT1. {ECO:0000305|PubMed:20606008}.; PTM: Ubiquitinated at Lys-279 via 'Lys-6'-linked polyubiquitin chains by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling), leading to its degradation by the proteasome and rescue of stalled ribosomes. {ECO:0000250|UniProtKB:P62495}.
uniprot
proteins
protein_family
Eukaryotic release factor 1 family
uniprot
proteins
pubmed
14636559
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20606008
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24486019
uniprot
proteins
sequence_length
437
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62495}.
uniprot
proteins