Tsc22d1
entrez
21807
canonical
uniprot
P62500
canonical
ensembl
ENSMUSG00000022010
resolver
ensp
ENSMUSP00000022587
resolver
ensp
ENSMUSP00000044517
resolver
ensp
ENSMUSP00000099140
resolver
ensp
ENSMUSP00000106513
resolver
ensp
ENSMUSP00000135296
resolver
ensp
ENSMUSP00000135493
resolver
ensp
ENSMUSP00000135561
resolver
ensp
ENSMUSP00000135806
resolver
enst
ENSMUST00000048371
resolver
enst
ENSMUST00000101618
resolver
enst
ENSMUST00000110888
resolver
enst
ENSMUST00000133224
resolver
enst
ENSMUST00000140251
resolver
enst
ENSMUST00000142683
resolver
enst
ENSMUST00000177207
resolver
genesymbol
Tsc22d1
resolver
genesymbol_syn
Kiaa1994
resolver
genesymbol_syn
Tgfb1i4
resolver
genesymbol_syn
Tilz1b
resolver
genesymbol_syn
Tsc22
resolver
uniprot
D3YW86
resolver
uniprot
D3Z0V7
resolver
uniprot
E9QLZ1
resolver
uniprot
H3BLI9
resolver
uniprot
Q00992
resolver
uniprot
Q3UXU0
resolver
uniprot
Q69Z44
resolver
uniprot
Q6PDK1
resolver
uniprot
Q9EQN4
resolver
uniprot_entry
D3YW86_MOUSE
resolver
uniprot_entry
D3Z0V7_MOUSE
resolver
uniprot_entry
E9QLZ1_MOUSE
resolver
uniprot_entry
H3BLI9_MOUSE
resolver
uniprot_entry
Q3UXU0_MOUSE
resolver
uniprot_entry
T22D1_MOUSE
resolver
uniprot_sec
Q00992
resolver
uniprot_sec
Q69Z44
resolver
uniprot_sec
Q6PDK1
resolver
uniprot_sec
Q9EQN4
resolver
amino_acid_sequence
MHQPPESTAAAAAAADISARKMAHPAMFPRRGSGGGSASALNAAGTGVSGAAPSSEDFPPPSLLQPPPPAASSTQGPQPPPPQSLNLLSQAQLQGQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHHLHHHHHPHHGHHLHHGHHHSSHAAVAGPSIPGGPPSSPVSRKLSTTGSSDGGVPVAPPPAVPSSGLPASVMTNIRTPSTTGSLGINSVTGTSATNNVNIAAVGSFSPSVTNSVHGNANINTSNIPNAASISGGPGVTSVVNSSILSGMGNGTVSSSPVANSVLNAAAGITVGVVSSQQQQQQQQQPTVNTSRFRVVKLDSTSEPFKKGRWTCTEFYEKENAVPATEGVAINKVVETVKQTPTEASSSERESTSGSSVSSSVSTLSHYTESVGSGEMMGAPAVVAPQQPPLPPAPPGLQGVALQQLEFSSPAPQSIAAVSMPQSISQSQMSQVQLQPQELSFQQKQTLQPVPLQATMSAATGIQPSPVSVVGVTAAVGQQPSVSSLAQPQLPYSQTAPPVQTPLPGAPPQQLQYGQQQPMVPAQIAPGHGQPVTQNPTSEYVQQQQQPIFQAALSSGQSSSTGTGAGISVIPVAQAQGIQLPGQPTAVQTQPAGAAGQPIGQAQTAVSTVPTGGQIASIGQQANIPTAVQQPSTQVTPSVIQQGAPPSSQVVLPAPTGIIHQGVQTRASSLPQQLVIAPQSTLVTVPPQPQGVETVAQGVVSQQLPTGSPLPSASTISVTNQVSSAAPSGMPSVPTNLVPPQNIAQPPATQNGSLVQSVSQSPLIATNINLPLAQQIPLSSTQFSTQSLAQAIGSQMEDARRPAEPSLGGLPQTMSGDSGGMSAVSDGSSSSLAAPASLFPLKVLPLTTPLVDGEDESSGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPPAQPASQGSGSTA
uniprot
proteins
function
FUNCTION: Transcriptional repressor (By similarity). Acts on the C-type natriuretic peptide (CNP) promoter (By similarity). Acts to promote CASP3-mediated apoptosis (By similarity). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (By similarity). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (By similarity). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (PubMed:20713358). Plays a role in the repression of hematopoietic precursor cell growth (PubMed:19329776). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201). {ECO:0000250|UniProtKB:Q15714, ECO:0000269|PubMed:19329776, ECO:0000269|PubMed:20713358, ECO:0000269|PubMed:26752201}.; FUNCTION: [Isoform 1]: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. {ECO:0000269|PubMed:19745830}.; FUNCTION: [Isoform 2]: Positively regulates cell death in response to TGFB3 during mammary gland involution. {ECO:0000269|PubMed:19745830}.
uniprot
proteins
mass_dalton
109811
uniprot
proteins
mutagenesis
MUTAGEN 1024; /note="L->A: Abolishes homodimerization; when associated with A-1030."; /evidence="ECO:0000269|PubMed:12468551"; MUTAGEN 1030; /note="L->A: Abolishes homodimerization; when associated with A-1024."; /evidence="ECO:0000269|PubMed:12468551
uniprot
proteins
protein_family
TSC-22/Dip/Bun family
uniprot
proteins
pubmed
12468551
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1587811
uniprot
proteins
pubmed
17147695
uniprot
proteins
pubmed
19329776
uniprot
proteins
pubmed
19745830
uniprot
proteins
pubmed
20713358
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26752201
uniprot
proteins
sequence_length
1077
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1587811, ECO:0000269|PubMed:19745830}. Nucleus {ECO:0000269|PubMed:1587811, ECO:0000269|PubMed:19745830}. Cell membrane {ECO:0000250|UniProtKB:Q15714}; Peripheral membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:Q15714}. Nucleus {ECO:0000250|UniProtKB:Q15714}. Mitochondrion {ECO:0000250|UniProtKB:Q15714}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:Q15714}. Nucleus {ECO:0000250|UniProtKB:Q15714}. Mitochondrion {ECO:0000250|UniProtKB:Q15714}.
uniprot
proteins