Q8K358
uniprot
Q8K358
canonical
amino_acid_sequence
MAAPLALVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLALLDLGVSPYSGAVFHETPLIIYLFHFLIDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSVFLSAVFLALATYQSLYPVTLFAPGLLYLLQRQYIPVKVKSKAFWIFSWEYAMMYTGSLVVIVCLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTVPLAIKLKEHPIFFMFIQIAIISIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAGSANSNFFYAITLTFNVGQILLISDYFYAFLRREYYLTHGLYLTAKDGTEAMLVLK
uniprot
proteins
function
FUNCTION: Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. Binds the lipid portion of GPI-anchor. May act as an organizer in the transmembrane layer to recruit other subunits, and thus is essential for assembly of the complex. {ECO:0000250|UniProtKB:Q9H490}.
uniprot
proteins
mass_dalton
49804
uniprot
proteins
pathway_participation
PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000250|UniProtKB:Q9H490}.
uniprot
proteins
protein_family
PIGU family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9H490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H490}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..22; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 137..157; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 158..177; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 178..193; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 194..204; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 222..243; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 286..305; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 311..330; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 331..344; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 354..371; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 384..405; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490
uniprot
proteins