ANKS4B
entrez
257629
canonical
uniprot
Q8N8V4
canonical
ensembl
ENSG00000175311
resolver
ensembl
ENSG00000284290
resolver
ensp
ENSP00000308772
resolver
ensp
ENSP00000491748
resolver
enst
ENST00000311620
resolver
enst
ENST00000639229
resolver
genesymbol
ANKS4B
resolver
genesymbol_syn
HARP
resolver
hgnc
HGNC:26795
resolver
uniprot_entry
ANS4B_HUMAN
resolver
amino_acid_sequence
MSTRYHQAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKKVTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSSKGTFSRSSPSNASAPGTFGSLSKGIKDTFKIKFKKNKDTAEQVGKEGRSGQRNVMEVFREEEEDSFSGDFKEKLQLSAEEDGSVHHESILNRPGLGSIVFRRNRISSPEDISDSKREFGFKLPSELLQRQGASEADEGAADEEGEENGLKDDLPWDDDEVEWEEDVVDATPLEVFLLSQHLEEFLPIFKREQIDLEALLLCSDEDLQSIQMQLGPRKKVLNAINRRKQVLQQPGQLVDTSL
uniprot
proteins
function
FUNCTION: As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (PubMed:26812018). May play a role in cellular response to endoplasmic reticulum stress (By similarity). {ECO:0000250|UniProtKB:Q8K3X6, ECO:0000269|PubMed:26812018}.
uniprot
proteins
mass_dalton
46597
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="L->P: Decreased localization to microvilli."; /evidence="ECO:0000269|PubMed:26812018"; MUTAGEN 417; /note="L->R: Decreased interaction with USH1C."; /evidence="ECO:0000269|PubMed:26812018
uniprot
proteins
pubmed
12588794
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26812017
uniprot
proteins
pubmed
26812018
uniprot
proteins
pubmed
32209652
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, microvillus {ECO:0000269|PubMed:26812018, ECO:0000269|PubMed:32209652}. Note=Localizes at the tip of microvilli (PubMed:26812018, PubMed:32209652). May associate with endoplasmic reticulum membranes (By similarity). {ECO:0000250|UniProtKB:Q8K3X6, ECO:0000269|PubMed:26812018, ECO:0000269|PubMed:32209652}.
uniprot
proteins