MTNR1B
entrez
4544
canonical
uniprot
P49286
canonical
ensembl
ENSG00000134640
resolver
ensp
ENSP00000257068
resolver
enst
ENST00000257068
resolver
genesymbol
MTNR1B
resolver
hgnc
HGNC:7464
resolver
uniprot_entry
MTR1B_HUMAN
resolver
amino_acid_sequence
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
uniprot
proteins
function
FUNCTION: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
uniprot
proteins
mass_dalton
40188
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10696804
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28827538
uniprot
proteins
pubmed
31019305
uniprot
proteins
pubmed
7568007
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 43..63; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 77..97; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 156..176; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 254..274; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 288..308; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins