NOTUM
entrez
147111
canonical
uniprot
Q6P988
canonical
ensembl
ENSG00000185269
resolver
ensp
ENSP00000387310
resolver
ensp
ENSP00000553579
resolver
ensp
ENSP00000629304
resolver
enst
ENST00000409678
resolver
enst
ENST00000883520
resolver
enst
ENST00000959245
resolver
genesymbol
NOTUM
resolver
hgnc
HGNC:27106
resolver
uniprot
Q8N410
resolver
uniprot
Q8NI82
resolver
uniprot_entry
NOTUM_HUMAN
resolver
uniprot_sec
Q8N410
resolver
uniprot_sec
Q8NI82
resolver
amino_acid_sequence
MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVEGNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHDSHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQPQGLEPSELLGMLSNGS
uniprot
proteins
ec_number
3.1.1.98
uniprot
proteins
function
FUNCTION: Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175). {ECO:0000269|PubMed:25731175}.
uniprot
proteins
mass_dalton
55699
uniprot
proteins
mutagenesis
MUTAGEN 232; /note="S->A: Abolishes enzyme activity. Unable to mediate serine depalmitoleoylation of WNT proteins."; /evidence="ECO:0000269|PubMed:25731175
uniprot
proteins
protein_family
Notum subfamily
uniprot
proteins
protein_family
Pectinacetylesterase family
uniprot
proteins
pubmed
12015973
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18429952
uniprot
proteins
pubmed
25731175
uniprot
proteins
pubmed
26091039
uniprot
proteins
sequence_length
496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9VUX3}.
uniprot
proteins