ARSK
entrez
153642
canonical
uniprot
Q6UWY0
canonical
ensembl
ENSG00000164291
resolver
ensp
ENSP00000369346
resolver
enst
ENST00000380009
resolver
genesymbol
ARSK
resolver
genesymbol_syn
TSULF
resolver
hgnc
HGNC:25239
resolver
uniprot
A2BDE3
resolver
uniprot
B4E1I4
resolver
uniprot
Q3ZCW3
resolver
uniprot
Q8N3Q8
resolver
uniprot_entry
ARSK_HUMAN
resolver
uniprot_sec
A2BDE3
resolver
uniprot_sec
B4E1I4
resolver
uniprot_sec
Q3ZCW3
resolver
uniprot_sec
Q8N3Q8
resolver
amino_acid_sequence
MLLLWVSVVAALALAVLAPGAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCPSRAAMWSGLFTHLTESWNNFKGLDPNYTTWMDVMERHGYRTQKFGKLDYTSGHHSISNRVEAWTRDVAFLLRQEGRPMVNLIRNRTKVRVMERDWQNTDKAVNWLRKEAINYTEPFVIYLGLNLPHPYPSPSSGENFGSSTFHTSLYWLEKVSHDAIKIPKWSPLSEMHPVDYYSSYTKNCTGRFTKKEIKNIRAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHRQFYKMSMYEASAHVPLLMMGPGIKAGLQVSNVVSLVDIYPTMLDIAGIPLPQNLSGYSLLPLSSETFKNEHKVKNLHPPWILSEFHGCNVNASTYMLRTNHWKYIAYSDGASILPQLFDLSSDPDELTNVAVKFPEITYSLDQKLHSIINYPKVSASVHQYNKEQFIKWKQSIGQNYSNVIANLRWHQDWQKEPRKYENAIDQWLKTHMNPRAV
uniprot
proteins
disease_involvement
DISEASE: Mucopolysaccharidosis 10 (MPS10) [MIM:619698]: A form of mucopolysaccharidosis, a group of lysosomal storage diseases characterized by defective degradation of glycosaminoglycans, resulting in their excessive accumulation and secretion. The diseases are progressive and often display a wide spectrum of clinical severity. MPS10 is an autosomal recessive childhood-onset disorder. Clinical features include disproportionate short-trunk short stature and skeletal, cardiac, and ophthalmologic abnormalities. {ECO:0000269|PubMed:34916232}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.6.1
uniprot
proteins
ec_number
3.1.6.18
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (PubMed:23986440). Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (PubMed:28055182, PubMed:34916232). Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (PubMed:28055182). {ECO:0000269|PubMed:23986440, ECO:0000269|PubMed:28055182, ECO:0000269|PubMed:34916232}.
uniprot
proteins
mass_dalton
61450
uniprot
proteins
mutagenesis
MUTAGEN 80; /note="C->A: Loss of arylsulfatase and glucuronate-2-sulfatase activity."; /evidence="ECO:0000269|PubMed:23986440, ECO:0000269|PubMed:28055182
uniprot
proteins
post_translational_modification
PTM: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. {ECO:0000269|PubMed:23986440}.; PTM: The 75-kDa precursor undergoes proteolytic processing to yield a 23 kDa form. {ECO:0000269|PubMed:23986440}.; PTM: N-glycosylated with both high mannose and complex type sugars. {ECO:0000269|PubMed:23986440}.
uniprot
proteins
protein_family
Sulfatase family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16174644
uniprot
proteins
pubmed
16500042
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23986440
uniprot
proteins
pubmed
28055182
uniprot
proteins
pubmed
34916232
uniprot
proteins
sequence_length
536
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23986440}. Lysosome {ECO:0000269|PubMed:23986440}.
uniprot
proteins