Tdrd9
entrez
74691
canonical
uniprot
Q14BI7
canonical
ensembl
ENSMUSG00000054003
resolver
ensp
ENSMUSP00000078022
resolver
ensp
ENSMUSP00000347818
resolver
genesymbol
Tdrd9
resolver
uniprot
B1Q3J8
resolver
uniprot
Q14AW6
resolver
uniprot_entry
TDRD9_MOUSE
resolver
uniprot_sec
B1Q3J8
resolver
uniprot_sec
Q14AW6
resolver
amino_acid_sequence
MLRKLTVDQINDWFTIGKTVTNVELLGLPPAFPAEAPREEVQRSEEVPNEDPTAQAQVPVKATAPARPASTSGRSLSQRSSEMEYINKYRQLEEQELDIYGQDQPPSGPGLRSPLAKLSNVACIPETTYKYPDLPINRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLVGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATINCKQFADYFAVPVQNKMNPAYVFEVEGKPHAIEEYYLNDLGHIYHSGLPYRLEEPVITKDVYEVAVSLIQMFDDLDMKESGNKTWSGAQFVSERSSVLVFLPGLGEINYMHELLTNMIHKRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCDQRKGRAGRVSKGYCYRLIPRDFWDSAIPDHVVPEMLRCPLGSTILKVKLLDMGEPRALLATALSPPSLSDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVSQQLGKLVVLGHVFGCLDECLIIAAALSLKNFFTMPFRQHLDGYRNKVHFSGSSRSDCLALVEAFRAWQACRQRGELRRPKDELDWGRLNYIQIKRIREVAELYEELKNRISQFNMFVGPHHPVLDQEYPYKQRFILQVVLAGAFYPNYFTFGQPDEEMAVRELAGKDPKTTVVLKHIPPYGFLYYKQLQSLFRQCGQVKSIVFDGAKAFVEFSRNPTERFKTLPAVNLAVKMSQLKVSLELSVHAAEEIEGKVQGGSVSKLRNTRVNVDFQKQTVDPMQVSFNTLDRPRTVADLLLTIDVTEVVEVGHFWGYRIDERNAELLKQLTAEINRLELVPLPIHPHPDLVCLAPFTDYNKESYFRAQILYVSGNSAEVFFVDYGNRSHVDLDLLREIPCQFLELPFQALEFKICKMRPSAKSLICGEHWSGGAHGRFAALVGGCPLLVKVFSIVHSVLHVDVYRYSGAQDAVNVRDVLIREGYAELAEESYESKQSYEVLKGFFAKSVDTMPDGSVSSPLKDDEKHLLRILLESFASNRLGAPNCKAVLHGPFNPYELKCHSLTRISKFRCVWIEKESINSVVISDSPADLHQRMLVAASLSVNETGSTMLLRETSLMPHIPGLPALLSMLFAPVMELRVDREGKCYTGVLCGLGWNSATEAPILPEHDIELAFDVRLNVEDIVEINILRAAINKLVCDGPNGSKYLGPERIAQLQENARQKLLGLFCRLKPREKITPQWHEKPYEWNQVDPRLIMEQAEPEGSPGKSTSLYQLHTPVVLSP
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:20059948, PubMed:28633017). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20059948, PubMed:28633017). Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4 (PubMed:28633017). {ECO:0000269|PubMed:20059948, ECO:0000269|PubMed:28633017}.
uniprot
proteins
mass_dalton
155980
uniprot
proteins
mutagenesis
MUTAGEN 257; /note="E->Q: In Tdrd9(KI); heterozygous and homozygous knockin male mice are infertile due to derepression of transposable elements. PiRNA biogenesis in not affected but piRNAs fail to accumulate in the nucleus."; /evidence="ECO:0000269|PubMed:28633017
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
protein_family
DEAH subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19584108
uniprot
proteins
pubmed
20011505
uniprot
proteins
pubmed
20059948
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28633017
uniprot
proteins
sequence_length
1383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20011505, ECO:0000269|PubMed:20059948, ECO:0000269|PubMed:28633017}. Nucleus {ECO:0000269|PubMed:20059948, ECO:0000269|PubMed:28633017}. Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies. {ECO:0000269|PubMed:20059948}.
uniprot
proteins