FMNL1
entrez
752
canonical
uniprot
O95466
canonical
ensembl
ENSG00000184922
resolver
ensp
ENSP00000329219
resolver
ensp
ENSP00000465474
resolver
genesymbol
FMNL1
resolver
genesymbol_syn
C17orf1
resolver
genesymbol_syn
C17orf1B
resolver
genesymbol_syn
FMNL
resolver
genesymbol_syn
FRL1
resolver
hgnc
HGNC:1212
resolver
uniprot
D2DGW2
resolver
uniprot
Q6DKG5
resolver
uniprot
Q6IBP3
resolver
uniprot
Q86UH1
resolver
uniprot
Q8N671
resolver
uniprot
Q8TDH1
resolver
uniprot
Q96H10
resolver
uniprot_entry
FMNL1_HUMAN
resolver
uniprot_sec
D2DGW2
resolver
uniprot_sec
Q6DKG5
resolver
uniprot_sec
Q6IBP3
resolver
uniprot_sec
Q86UH1
resolver
uniprot_sec
Q8N671
resolver
uniprot_sec
Q8TDH1
resolver
uniprot_sec
Q96H10
resolver
amino_acid_sequence
MGNAAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYDNEKKWELICDQERFQVKNPPAAYIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQVLRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKPLEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLERLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRERFSESTAMGPSRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFLRANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIEDIITVIKTVPFTARTGKRTSRLLCEASLGEEMPL
uniprot
proteins
function
FUNCTION: Plays a role in actin cytoskeleton dynamics and regulation of cell shape (PubMed:21834987). {ECO:0000269|PubMed:21834987}.
uniprot
proteins
mass_dalton
121854
uniprot
proteins
post_translational_modification
PTM: Myristoylation mediates membrane localization and blebbing. {ECO:0000269|PubMed:19815554}.
uniprot
proteins
protein_family
Formin homology family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19815554
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21148482
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21834987
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
39390519
uniprot
proteins
pubmed
9799091
uniprot
proteins
sequence_length
1100
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:19815554}; Lipid-anchor {ECO:0000269|PubMed:19815554}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cell cortex. Cell projection, bleb. Note=Colocalized with F-actin in bleb protrusions.
uniprot
proteins