Actl9
entrez
69481
canonical
uniprot
Q8CG27
canonical
ensembl
ENSMUSG00000092519
resolver
ensp
ENSMUSP00000134564
resolver
enst
ENSMUST00000174088
resolver
genesymbol
Actl9
resolver
genesymbol_syn
Actl7c
resolver
uniprot
Q497R1
resolver
uniprot
Q5EBK5
resolver
uniprot_entry
ACTL9_MOUSE
resolver
uniprot_sec
Q497R1
resolver
uniprot_sec
Q5EBK5
resolver
amino_acid_sequence
MDVNGHPKFQPSPETDGPLPLTSSTLMVSKSLQQDSLSMVGDRLPPKTGAVVIDMGTGTCKVGFAGQSQPTYTVATILGCQPKKQATKDQSELETFIGEAARSRPELRLVKPIRNGIVVDWEAAELIWRHILEHDLQVATHEHPLLFSDPPFSPATNREKLVEVAFESLHSPALYVASQSVLSVYAHGRVNGLVVDTGHGVSYTVPVVQGYNLPHAIQRLDLAGNHLTAFLAEMLLGSGFSLQQEDLDLVENIKHHYCYLAPDFQKEQARPDEECKQSLKLPDGRTVTLGKELFQCPELLFHPPEIPGLSPIGLPAMAEQSLLKVPQELRPHVARNVILCGGSSLFTGLEGRFRAELLHSLSPEDHVVVMAHPNRNLSVWIGGSILASLHAFQSCWVLREQYEERGPQVVYRKCY
uniprot
proteins
function
FUNCTION: Testis-specic protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation. {ECO:0000269|PubMed:33626338}.
uniprot
proteins
mass_dalton
45771
uniprot
proteins
mutagenesis
MUTAGEN 379; /note="V->L: Homozygous knockin male mice are infertile. Testis size, sperm concentration, viability and motility are normal. However the acrosome is detached from the nuclear envelope in sperm. Proacrosomal vesicles in the Golgi phase are atypical and separated in testis and they failed to fuse in the cap phase."; /evidence="ECO:0000269|PubMed:33626338
uniprot
proteins
protein_family
Actin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33626338
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8TC94}. Cytoplasm, cytoskeleton, perinuclear theca {ECO:0000250|UniProtKB:Q8TC94}. Note=Localizes predominantly in the equatorial segment of the sperm head and neck regions, with some localization in the acrosomal segment of the head. Colocalizes in the acrosomal and equatorial segments of sperm with ACTL7A. Colocalizes with PLCZ1 in the equatorial segment of the head of capacitated sperm. {ECO:0000250|UniProtKB:Q8TC94}.
uniprot
proteins