Phb1
entrez
25344
canonical
uniprot
P67779
canonical
ensembl
ENSRNOG00000046799
resolver
ensembl
ENSRNOG00055032766
resolver
ensembl
ENSRNOG00060025492
resolver
ensembl
ENSRNOG00065018762
resolver
ensp
ENSRNOP00000066502
resolver
ensp
ENSRNOP00055046752
resolver
ensp
ENSRNOP00060036599
resolver
ensp
ENSRNOP00065025087
resolver
enst
ENSRNOT00000075733
resolver
enst
ENSRNOT00055056646
resolver
enst
ENSRNOT00060044120
resolver
enst
ENSRNOT00065031490
resolver
genesymbol
Phb1
resolver
genesymbol_syn
Phb
resolver
uniprot
P24142
resolver
uniprot
Q4V8M6
resolver
uniprot_entry
PHB1_RAT
resolver
uniprot_sec
P24142
resolver
uniprot_sec
Q4V8M6
resolver
amino_acid_sequence
MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIYTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLPQ
uniprot
proteins
function
FUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus. Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity) (PubMed:1996099). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (PubMed:32173312). {ECO:0000250|UniProtKB:P67778, ECO:0000269|PubMed:1996099, ECO:0000269|PubMed:32173312}.; FUNCTION: In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner. Regulates mitochondrial respiration activity playing a role in cellular aging. The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (By similarity). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (By similarity). {ECO:0000250|UniProtKB:P35232, ECO:0000250|UniProtKB:P67778}.; FUNCTION: In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses. Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells. {ECO:0000250|UniProtKB:P35232}.; FUNCTION: In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. {ECO:0000250|UniProtKB:P67778}.
uniprot
proteins
mass_dalton
29820
uniprot
proteins
protein_family
Prohibitin family
uniprot
proteins
pubmed
11302691
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19423663
uniprot
proteins
pubmed
1996099
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
32173312
uniprot
proteins
sequence_length
272
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11302691}. Nucleus {ECO:0000250|UniProtKB:P35232}. Cytoplasm {ECO:0000250|UniProtKB:P35232}. Cell membrane {ECO:0000250|UniProtKB:P35232}.
uniprot
proteins