SLC5A11
entrez
115584
canonical
uniprot
Q8WWX8
canonical
ensembl
ENSG00000158865
resolver
ensembl
ENSG00000288216
resolver
ensp
ENSP00000289932
resolver
ensp
ENSP00000416782
resolver
ensp
ENSP00000454401
resolver
ensp
ENSP00000456234
resolver
ensp
ENSP00000456376
resolver
ensp
ENSP00000457179
resolver
ensp
ENSP00000569749
resolver
ensp
ENSP00000648605
resolver
genesymbol
SLC5A11
resolver
genesymbol_syn
KST1
resolver
genesymbol_syn
SLGTX
resolver
genesymbol_syn
SMIT2
resolver
hgnc
HGNC:23091
resolver
uniprot
B7Z329
resolver
uniprot
B7Z8N3
resolver
uniprot
Q05BF1
resolver
uniprot
Q6PF02
resolver
uniprot
Q6ZUW3
resolver
uniprot
Q86Y55
resolver
uniprot
Q96PP5
resolver
uniprot_entry
B7Z8N3_HUMAN
resolver
uniprot_entry
SC5AB_HUMAN
resolver
uniprot_sec
B7Z329
resolver
uniprot_sec
Q05BF1
resolver
uniprot_sec
Q6PF02
resolver
uniprot_sec
Q6ZUW3
resolver
uniprot_sec
Q86Y55
resolver
uniprot_sec
Q96PP5
resolver
activity_regulation
ACTIVITY REGULATION: MI transport activity inhibited by D-chiro-inositol (DCI), phlorizin (Pz) and sodium (Na(+)) (By similarity). Insulin increases D-chiro-inositol uptake (PubMed:19032932). {ECO:0000250|UniProtKB:Q9Z1F2, ECO:0000269|PubMed:19032932}.
uniprot
proteins
amino_acid_sequence
MESGTSSPQPPQLDPLDAFPQKGLEPGDIAVLVLYFLFVLAVGLWSTVKTKRDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSGAATGISVSAYELNGLFSVLMLAWIFLPIYIAGQVTTMPEYLRKRFGGIRIPIILAVLYLFIYIFTKISVDMYAGAIFIQQSLHLDLYLAIVGLLAITAVYTVAGGLAAVIYTDALQTLIMLIGALTLMGYSFAAVGGMEGLKEKYFLALASNRSENSSCGLPREDAFHIFRDPLTSDLPWPGVLFGMSIPSLWYWCTDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPLFIMVFPGMVSRILFPDQVACADPEICQKICSNPSGCSDIAYPKLVLELLPTGLRGLMMAVMVAALMSSLTSIFNSASTIFTMDLWNHLRPRASEKELMIVGRVFVLLLVLVSILWIPVVQASQGGQLFIYIQSISSYLQPPVAVVFIMGCFWKRTNEKGAFWGLISGLLLGLVRLVLDFIYVQPRCDQPDERPVLVKSIHYLYFSMILSTVTLITVSTVSWFTEPPSKEMVSHLTWFTRHDPVVQKEQAPPAAPLSLTLSQNGMPEASSSSSVQFEMVQENTSKTHSCDMTPKQSKVVKAILWLCGIQEKGKEELPARAEAIIVSLEENPLVKTLLDVNLIFCVSCAIFIWGYFA
uniprot
proteins
function
FUNCTION: Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1 (PubMed:15172003, PubMed:19032932). Exclusively responsible for apical MI transport and absorption in intestine (By similarity). Can also transport D-chiro-inositol (DCI) but not L-fucose (PubMed:15172003, PubMed:19032932). Exhibits stereospecific cotransport of both D-glucose and D-xylose (By similarity). May induce apoptosis through the TNF, PDCD1 pathway (PubMed:15172003, PubMed:18069935). May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity). {ECO:0000250|UniProtKB:Q28728, ECO:0000250|UniProtKB:Q9Z1F2, ECO:0000269|PubMed:15172003, ECO:0000269|PubMed:18069935, ECO:0000269|PubMed:19032932}.
uniprot
proteins
mass_dalton
74036
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
12039040
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15172003
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
18069935
uniprot
proteins
pubmed
19032932
uniprot
proteins
sequence_length
675
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:19032932}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q9Z1F2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Z1F2}. Note=Located on apical membrane of enterocytes (By similarity). Located on membrane of kidney brush border membrane vesicles (BBMVs) and apical membrane of proximal convoluted tubules (By similarity). {ECO:0000250|UniProtKB:Q28728, ECO:0000250|UniProtKB:Q9Z1F2}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..48; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 66..88; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 181..201; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 209..229; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 273..293; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 309..329; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 376..396; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 419..439; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 447..467; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 480..500; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 522..542; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 655..675; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins