Cd48
entrez
12506
canonical
uniprot
P18181
canonical
ensembl
ENSMUSG00000015355
resolver
ensp
ENSMUSP00000015499
resolver
ensp
ENSMUSP00000064241
resolver
enst
ENSMUST00000015499
resolver
enst
ENSMUST00000068584
resolver
genesymbol
Cd48
resolver
genesymbol_syn
Bcm-1
resolver
uniprot
F8WHM0
resolver
uniprot
Q545K2
resolver
uniprot_entry
CD48_MOUSE
resolver
uniprot_entry
F8WHM0_MOUSE
resolver
uniprot_sec
Q545K2
resolver
amino_acid_sequence
MCFIKQGWCLVLELLLLPLGTGFQGHSIPDINATTGSNVTLKIHKDPLGPYKRITWLHTKNQKILEYNYNSTKTIFESEFKGRVYLEENNGALHISNVRKEDKGTYYMRVLRETENELKITLEVFDPVPKPSIEINKTEASTDSCHLRLSCEVKDQHVDYTWYESSGPFPKKSPGYVLDLIVTPQNKSTFYTCQVSNPVSSKNDTVYFTLPCDLARSSGVCWTATWLVVTTLIIHRILLT
uniprot
proteins
function
FUNCTION: Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation (PubMed:21278219, PubMed:9881969). Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation (PubMed:9881969). Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells (By similarity) (PubMed:21278219, PubMed:9881969). {ECO:0000250|UniProtKB:P09326, ECO:0000269|PubMed:21278219, ECO:0000269|PubMed:9881969}.
uniprot
proteins
mass_dalton
27383
uniprot
proteins
pubmed
1383383
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1693656
uniprot
proteins
pubmed
17950006
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21278219
uniprot
proteins
pubmed
8475091
uniprot
proteins
pubmed
9881969
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1383383}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:1693656}. Membrane raft {ECO:0000250|UniProtKB:P09326}. Secreted {ECO:0000250|UniProtKB:P09326}.
uniprot
proteins