PDE4A
entrez
5141
canonical
uniprot
P27815
canonical
ensembl
ENSG00000065989
resolver
ensp
ENSP00000293683
resolver
ensp
ENSP00000341007
resolver
ensp
ENSP00000370078
resolver
ensp
ENSP00000394754
resolver
ensp
ENSP00000468507
resolver
genesymbol
PDE4A
resolver
genesymbol_syn
DPDE2
resolver
hgnc
HGNC:8780
resolver
uniprot
O75522
resolver
uniprot
O76092
resolver
uniprot
Q16255
resolver
uniprot
Q16691
resolver
uniprot
Q5DM53
resolver
uniprot
Q6PMT2
resolver
uniprot
Q8IVA7
resolver
uniprot
Q8WUQ3
resolver
uniprot
Q9H3H2
resolver
uniprot_entry
PDE4A_HUMAN
resolver
uniprot_sec
O75522
resolver
uniprot_sec
O76092
resolver
uniprot_sec
Q16255
resolver
uniprot_sec
Q16691
resolver
uniprot_sec
Q5DM53
resolver
uniprot_sec
Q6PMT2
resolver
uniprot_sec
Q8IVA7
resolver
uniprot_sec
Q8WUQ3
resolver
uniprot_sec
Q9H3H2
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform 1]: Inhibited by rolipram, cilomilast, Ro 20-1724, roflumilast and denbufylline. {ECO:0000269|PubMed:15738310}.; ACTIVITY REGULATION: [Isoform 2]: Inhibited by rolipram, cilomilast, Ro 20-1724, roflumilast and denbufylline. {ECO:0000269|PubMed:15738310}.; ACTIVITY REGULATION: [Isoform 3]: Inhibited by rolipram. {ECO:0000269|PubMed:7888306}.; ACTIVITY REGULATION: [Isoform 4]: Inhibited by rolipram. {ECO:0000269|PubMed:9677330}.; ACTIVITY REGULATION: [Isoform 6]: Inhibited by rolipram, cilomilast, Ro 20-1724, roflumilast and denbufylline. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; ACTIVITY REGULATION: [Isoform 7]: Inhibited by rolipram and cilomilast. {ECO:0000269|PubMed:18095939}.
uniprot
proteins
amino_acid_sequence
MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
uniprot
proteins
ec_number
3.1.4.53
uniprot
proteins
function
FUNCTION: Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}.
uniprot
proteins
mass_dalton
98143
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. {ECO:0000305|PubMed:15738310}.
uniprot
proteins
post_translational_modification
PTM: [Isoform 1]: Proteolytically cleaved by CASP3. {ECO:0000269|PubMed:15738310}.; PTM: [Isoform 2]: Phosphorylated at Ser-119 by PKA. {ECO:0000269|PubMed:15738310}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE4 subfamily
uniprot
proteins
pubmed
11306681
uniprot
proteins
pubmed
11566027
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15738310
uniprot
proteins
pubmed
17727341
uniprot
proteins
pubmed
18095939
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20196770
uniprot
proteins
pubmed
2160582
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
7772058
uniprot
proteins
pubmed
7888306
uniprot
proteins
pubmed
8413254
uniprot
proteins
pubmed
9677330
uniprot
proteins
sequence_length
886
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15738310}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15738310}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15738310}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytosol {ECO:0000269|PubMed:7888306}.; SUBCELLULAR LOCATION: [Isoform 4]: Membrane; Peripheral membrane protein {ECO:0000269|PubMed:9677330}. Note=Isoform 4 has propensity for association with membranes. {ECO:0000269|PubMed:9677330}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm, cytosol. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:18095939}. Note=Predominantly cytosolic. {ECO:0000269|PubMed:18095939}.
uniprot
proteins