LRRC15
entrez
131578
canonical
uniprot
Q8TF66
canonical
ensembl
ENSG00000172061
resolver
ensp
ENSP00000306276
resolver
ensp
ENSP00000413707
resolver
genesymbol
LRRC15
resolver
genesymbol_syn
LIB
resolver
hgnc
HGNC:20818
resolver
uniprot
B3KWI4
resolver
uniprot
Q495Q6
resolver
uniprot
Q7RTN7
resolver
uniprot_entry
B3KWI4_HUMAN
resolver
uniprot_entry
LRC15_HUMAN
resolver
uniprot_sec
Q495Q6
resolver
uniprot_sec
Q7RTN7
resolver
amino_acid_sequence
MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLAIAAIVIGIVALACSLAACVGCCCCKKRSQAVLMQMKAPNEC
uniprot
proteins
function
FUNCTION: (Microbial infection) Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein (PubMed:36228039, PubMed:36735681, PubMed:36757924). Does not act as a SARS-CoV-2 entry receptor but sequesters virions and antagonizes in trans SARS-CoV-2 infection of ACE2(+) cells when expressed on nearby cells (PubMed:36228039, PubMed:36757924). {ECO:0000269|PubMed:36228039, ECO:0000269|PubMed:36735681, ECO:0000269|PubMed:36757924}.
uniprot
proteins
mass_dalton
64366
uniprot
proteins
pubmed
11785964
uniprot
proteins
pubmed
12923058
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
34702854
uniprot
proteins
pubmed
36228039
uniprot
proteins
pubmed
36735681
uniprot
proteins
pubmed
36757924
uniprot
proteins
sequence_length
581
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:36228039, ECO:0000269|PubMed:36735681, ECO:0000269|PubMed:36757924}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 539..559; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins