Tgfb2
entrez
21808
canonical
uniprot
P27090
canonical
ensembl
ENSMUSG00000039239
resolver
ensp
ENSMUSP00000043849
resolver
ensp
ENSMUSP00000142149
resolver
ensp
ENSMUSP00000310857
resolver
ensp
ENSMUSP00000310858
resolver
enst
ENSMUST00000045288
resolver
enst
ENSMUST00000195201
resolver
genesymbol
Tgfb2
resolver
uniprot
A0A0A6YXU9
resolver
uniprot
Q3TWH5
resolver
uniprot
Q8CDZ9
resolver
uniprot
Q91VP5
resolver
uniprot_entry
A0A0A6YXU9_MOUSE
resolver
uniprot_entry
Q3TWH5_MOUSE
resolver
uniprot_entry
Q8CDZ9_MOUSE
resolver
uniprot_entry
TGFB2_MOUSE
resolver
uniprot_sec
Q91VP5
resolver
amino_acid_sequence
MHYCVLSTFLLLHLVPVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPDEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPSHLPSENAIPPTFYRPYFRIVRFDVSTMEKNASNLVKAEFRVFRLQNPKARVAEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVQEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYASGDQKTIKSTRKKTSGKTPHLLLMLLPSYRLESQQSSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHTKVLSLYNTINPEASASPCCVSQDLEPLTILYYIGNTPKIEQLSNMIVKSCKCS
uniprot
proteins
function
FUNCTION: [Transforming growth factor beta-2 proprotein]: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. {ECO:0000250|UniProtKB:P01137, ECO:0000250|UniProtKB:P04202}.; FUNCTION: [Latency-associated peptide]: Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2. {ECO:0000250|UniProtKB:P01137, ECO:0000250|UniProtKB:P04202}.; FUNCTION: [Transforming growth factor beta-2]: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). {ECO:0000250|UniProtKB:P01137, ECO:0000250|UniProtKB:P04202, ECO:0000250|UniProtKB:P61812}.
uniprot
proteins
mass_dalton
47589
uniprot
proteins
post_translational_modification
PTM: [Transforming growth factor beta-2]: The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-2 (TGF-beta-2) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-2 inactive. {ECO:0000250|UniProtKB:P01137}.
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
14973287
uniprot
proteins
pubmed
14985127
uniprot
proteins
pubmed
15206957
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23963447
uniprot
proteins
pubmed
2797004
uniprot
proteins
sequence_length
414
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P01137}.; SUBCELLULAR LOCATION: [Transforming growth factor beta-2]: Secreted {ECO:0000250|UniProtKB:P01137}.
uniprot
proteins