Q8IYR6
uniprot
Q8IYR6
canonical
amino_acid_sequence
MGAAAAEAPLRLPAAPPLAFCCYTSVLLLFAFSLPGSRASNQPPGGGGGSGGDCPGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNRGRRQKQNLGHFTSDTSSRMV
uniprot
proteins
disease_involvement
DISEASE: Note=Encephalopathy, acute, infection-induced, herpes-specific (IIAE) (PubMed:39048830). A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals (PubMed:39048830). It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes (PubMed:39048830). Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome (PubMed:39048830). Disease susceptibility is associated with variants affecting the gene represented in this entry (PubMed:39048830). {ECO:0000269|PubMed:39048830}.
uniprot
proteins
function
FUNCTION: Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry (PubMed:39048823, PubMed:39048830). Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent (PubMed:39048823). Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane (PubMed:39048823, PubMed:39048830). Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors (PubMed:39048823). May be a tumor suppressor in brain cancers (PubMed:12743596). {ECO:0000269|PubMed:12743596, ECO:0000269|PubMed:39048823, ECO:0000269|PubMed:39048830}.
uniprot
proteins
mass_dalton
40934
uniprot
proteins
protein_family
Tomoregulin family
uniprot
proteins
pubmed
12743596
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16407223
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
39048823
uniprot
proteins
pubmed
39048830
uniprot
proteins
pubmed
8752111
uniprot
proteins
sequence_length
380
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12743596, ECO:0000269|PubMed:39048830}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 331..351; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins