Dclre1b
entrez
310745
canonical
uniprot
Q4KLY6
canonical
ensembl
ENSRNOG00000019367
resolver
ensp
ENSRNOP00000026213
resolver
enst
ENSRNOT00000026213
resolver
genesymbol
Dclre1b
resolver
genesymbol_syn
Snm1b
resolver
uniprot
G3V8I3
resolver
uniprot_entry
DCR1B_RAT
resolver
uniprot_entry
G3V8I3_RAT
resolver
amino_acid_sequence
MNGVVIPQTPIAVDFWSLRRAGTARLFFLSHMHCDHTVGLSSTWARPLYCSPITAHLLHRRLQVSKQWIRALEIGESHVLLLDEIGQETMTVTLIDANHCPGSVMFLFEGYFGTILYTGDFRYTPSMLKEPALTLGKQIHTLYLDNTNCNPALVLPSRQEATQQIIQLIRQFPQHNIKIGLYSLGKESLLEQLALEFQTWVVLSPQRLELVQLLGLADVFTVEEEAGRIHAVDHMEICHSAMLQWNQTHPTIAIFPTSRKIRSPHPSIYSIPYSDHSSYSELRAFVAALRPCQVVPIVREQPCGEFFQDSLSPRLSMPLIPHSVQQYMSSSSRKTNVFWQLERRLKRPRTQGVVFESPEEKADQVKVDRDSKKHKKESLSPWAGCLSRLCPHPLQARKQLFPDFCRKEGDEPVLFCDSNKMATVLTAPLELSVQLQPVDEFPFPETREEIGLGSPLWSGGGSGSPTRGKQSNGMGCGSPPTHISRTTHLTPESGGLALKYLLTPVDFLQAGFSSRNFDQQVEKHQRVQCNNPAVMNTVDDV
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
ec_number
3.5.2.6
uniprot
proteins
function
FUNCTION: 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint (By similarity). Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (By similarity). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
60924
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation. Interaction with TERF2 protects it from ubiquitination (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
DNA repair metallo-beta-lactamase (DRMBL) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome, telomere {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome (By similarity). {ECO:0000250}.
uniprot
proteins