Gbp2
entrez
14469
canonical
uniprot
Q9Z0E6
canonical
ensembl
ENSMUSG00000028270
resolver
ensp
ENSMUSP00000132435
resolver
enst
ENSMUST00000165774
resolver
genesymbol
Gbp2
resolver
uniprot
Q4FK03
resolver
uniprot
Q8CIC6
resolver
uniprot
Q921N2
resolver
uniprot
Q9R1I0
resolver
uniprot_entry
GBP2_MOUSE
resolver
uniprot_sec
Q4FK03
resolver
uniprot_sec
Q8CIC6
resolver
uniprot_sec
Q921N2
resolver
uniprot_sec
Q9R1I0
resolver
amino_acid_sequence
MASEIHMSEPMCLIENTEAQLVINQEALRILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKRTGFSLGSTVQSHTKGIWMWCVPHPKKAGQTLVLLDTEGLEDVEKGDNQNDCWIFALAVLLSSTFIYNSIGTINQQAMDQLHYVTELTDLIKSKSSPDQSGVDDSANFVGFFPTFVWTLRDFSLELEVNGKPVTSDEYLEHSLTLKKGADKKTKSFNEPRLCIRKFFPKRKCFIFDRPAQRKQLSKLETLREEELCGEFVEQVAEFTSYILSYSSVKTLCGGIIVNGPRLKSLVQTYVGAISNGSLPCMESAVLTLAQIENSAAVQKAITHYEEQMNQKIQMPTETLQELLDLHRPIESEAIEVFLKNSFKDVDQKFQTELGNLLVAKRDAFIKKNMDVSSARCSDLLEDIFGPLEEEVKLGTFSKPGGYYLFLQMRQELEKKYNQAPGKGLQAEAMLKNYFDSKADVVETLLQTDQSLTEAAKEVEEERTKAEAAEAANRELEKKQKEFELMMQQKEKSYQEHVKKLTEKMKDEQKQLLAEQENIIAAKLREQEKFLKEGFENESKKLIREIDTLKQNKSSGKCTIL
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:18025219, PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716, PubMed:27693356, PubMed:30062052). Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis, such as Gm12250/Irgb10: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716, PubMed:27693356, PubMed:30062052). Confers protection to the protozoan pathogen Toxoplasma gondii (PubMed:18025219). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity by inhibiting FURIN-mediated maturation of viral envelope proteins (By similarity). {ECO:0000250|UniProtKB:P32456, ECO:0000269|PubMed:18025219, ECO:0000269|PubMed:24715728, ECO:0000269|PubMed:24739961, ECO:0000269|PubMed:25774715, ECO:0000269|PubMed:25774716, ECO:0000269|PubMed:27693356, ECO:0000269|PubMed:30062052}.
uniprot
proteins
mass_dalton
66739
uniprot
proteins
post_translational_modification
PTM: Isoprenylation is required for proper subcellular location. {ECO:0000250|UniProtKB:P32456}.
uniprot
proteins
protein_family
GB1 subfamily
uniprot
proteins
protein_family
GB1/RHD3 GTPase family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
10386861
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18025219
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24715728
uniprot
proteins
pubmed
24739961
uniprot
proteins
pubmed
25774715
uniprot
proteins
pubmed
25774716
uniprot
proteins
pubmed
27693356
uniprot
proteins
pubmed
30062052
uniprot
proteins
pubmed
31964735
uniprot
proteins
pubmed
9858320
uniprot
proteins
pubmed
9862701
uniprot
proteins
sequence_length
589
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18025219, ECO:0000269|PubMed:31964735}; Lipid-anchor {ECO:0000250|UniProtKB:P32456}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P32456}; Lipid-anchor {ECO:0000250|UniProtKB:P32456}. Cytoplasm {ECO:0000250|UniProtKB:P32456}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P32456}. Note=GBP2-GBP5 dimers localize to the Golgi apparatus. {ECO:0000250|UniProtKB:P32456}.
uniprot
proteins