SLFN11
entrez
91607
canonical
uniprot
Q7Z7L1
canonical
ensembl
ENSG00000172716
resolver
ensp
ENSP00000312402
resolver
ensp
ENSP00000378067
resolver
ensp
ENSP00000510787
resolver
ensp
ENSP00000554453
resolver
ensp
ENSP00000554454
resolver
ensp
ENSP00000554455
resolver
ensp
ENSP00000554456
resolver
ensp
ENSP00000554457
resolver
ensp
ENSP00000554458
resolver
ensp
ENSP00000607359
resolver
ensp
ENSP00000621911
resolver
ensp
ENSP00000621912
resolver
ensp
ENSP00000621913
resolver
enst
ENST00000308377
resolver
enst
ENST00000394566
resolver
enst
ENST00000685675
resolver
enst
ENST00000884394
resolver
enst
ENST00000884395
resolver
enst
ENST00000884396
resolver
enst
ENST00000884397
resolver
enst
ENST00000884398
resolver
enst
ENST00000884399
resolver
enst
ENST00000937300
resolver
enst
ENST00000951852
resolver
enst
ENST00000951853
resolver
enst
ENST00000951854
resolver
genesymbol
SLFN11
resolver
hgnc
HGNC:26633
resolver
uniprot
E1P643
resolver
uniprot
Q8N3S8
resolver
uniprot
Q8N762
resolver
uniprot
Q8TEE0
resolver
uniprot_entry
SLN11_HUMAN
resolver
uniprot_sec
E1P643
resolver
uniprot_sec
Q8N3S8
resolver
uniprot_sec
Q8N762
resolver
uniprot_sec
Q8TEE0
resolver
amino_acid_sequence
MEANQCPLVVEPSYPDLVINVGEVTLGEENRKKLQKIQRDQEKERVMRAACALLNSGGGVIRMAKKVEHPVEMGLDLEQSLRELIQSSDLQAFFETKQQGRCFYIFVKSWSSGPFPEDRSVKPRLCSLSSSLYRRSETSVRSMDSREAFCFLKTKRKPKILEEGPFHKIHKGVYQELPNSDPADPNSDPADLIFQKDYLEYGEILPFPESQLVEFKQFSTKHFQEYVKRTIPEYVPAFANTGGGYLFIGVDDKSREVLGCAKENVDPDSLRRKIEQAIYKLPCVHFCQPQRPITFTLKIVNVLKRGELYGYACMIRVNPFCCAVFSEAPNSWIVEDKYVCSLTTEKWVGMMTDTDPDLLQLSEDFECQLSLSSGPPLSRPVYSKKGLEHKKELQQLLFSVPPGYLRYTPESLWRDLISEHRGLEELINKQMQPFFRGILIFSRSWAVDLNLQEKPGVICDALLIAQNSTPILYTILREQDAEGQDYCTRTAFTLKQKLVNMGGYTGKVCVRAKVLCLSPESSAEALEAAVSPMDYPASYSLAGTQHMEALLQSLVIVLLGFRSLLSDQLGCEVLNLLTAQQYEIFSRSLRKNRELFVHGLPGSGKTIMAMKIMEKIRNVFHCEAHRILYVCENQPLRNFISDRNICRAETRKTFLRENFEHIQHIVIDEAQNFRTEDGDWYGKAKSITRRAKGGPGILWIFLDYFQTSHLDCSGLPPLSDQYPREELTRIVRNADPIAKYLQKEMQVIRSNPSFNIPTGCLEVFPEAEWSQGVQGTLRIKKYLTVEQIMTCVADTCRRFFDRGYSPKDVAVLVSTAKEVEHYKYELLKAMRKKRVVQLSDACDMLGDHIVLDSVRRFSGLERSIVFGIHPRTADPAILPNVLICLASRAKQHLYIFPWGGH
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signaling (PubMed:30374083). Antiviral restriction factor with manganese-dependent type II tRNA endoribonuclease (PubMed:36115853). A single tRNA molecule is bound and cleaved by the SLFN11 dimer (PubMed:36115853). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Impairs the replication of human cytomegalovirus (HCMV) and some Flaviviruses (PubMed:35105802, PubMed:36115853). Exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900, ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061, ECO:0000269|PubMed:30374083, ECO:0000269|PubMed:35105802, ECO:0000269|PubMed:36115853}.
uniprot
proteins
mass_dalton
102836
uniprot
proteins
mutagenesis
MUTAGEN 209; /note="E->A: Complete loss of endonuclease activity."; /evidence="ECO:0000269|PubMed:36115853"; MUTAGEN 214; /note="E->A: Complete loss of endonuclease activity."; /evidence="ECO:0000269|PubMed:36115853"; MUTAGEN 216; /note="K->A: Complete loss of endonuclease activity."; /evidence="ECO:0000269|PubMed:36115853"; MUTAGEN 234; /note="Y->A: No effect on endonuclease activity."; /evidence="ECO:0000269|PubMed:36115853"; MUTAGEN 252; /note="D->A: Slight increase in endonuclease activity."; /evidence="ECO:0000269|PubMed:36115853"; MUTAGEN 605; /note="K->M: Abolishes ATPase activity without affecting its role in DNA damage response; when associated with A-668."; /evidence="ECO:0000269|PubMed:26658330"; MUTAGEN 668; /note="D->A: Abolishes ATPase activity without affecting its role in DNA damage response; when associated with M-605."; /evidence="ECO:0000269|PubMed:26658330"; MUTAGEN 669; /note="E->Q: Abolishes ATPase activity, leading to abolish ability to inhibit DNA replication without affecting subcellular location."; /evidence="ECO:0000269|PubMed:29395061"; MUTAGEN 753; /note="S->D: Complete loss of tRNA cleavage and ssDNA binding."; /evidence="ECO:0000269|PubMed:36115853
uniprot
proteins
protein_family
Schlafen family
uniprot
proteins
protein_family
Subgroup III subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20956525
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22927417
uniprot
proteins
pubmed
23000900
uniprot
proteins
pubmed
26625211
uniprot
proteins
pubmed
26658330
uniprot
proteins
pubmed
27440269
uniprot
proteins
pubmed
28196596
uniprot
proteins
pubmed
28212573
uniprot
proteins
pubmed
29395061
uniprot
proteins
pubmed
30374083
uniprot
proteins
pubmed
35105802
uniprot
proteins
pubmed
36115853
uniprot
proteins
sequence_length
901
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061}. Chromosome {ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061}. Note=Recruited to stressed replication forks carrying extended RPA filaments (PubMed:29395061). Recruited to DNA damage sites via interaction with RPA1 (PubMed:26658330, PubMed:29395061). {ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061}.
uniprot
proteins