Efnb1
entrez
13641
canonical
uniprot
P52795
canonical
ensembl
ENSMUSG00000031217
resolver
ensp
ENSMUSP00000050716
resolver
enst
ENSMUST00000052839
resolver
genesymbol
Efnb1
resolver
genesymbol_syn
Epl2
resolver
genesymbol_syn
Eplg2
resolver
genesymbol_syn
Lerk2
resolver
genesymbol_syn
Stra1
resolver
uniprot
Q544L9
resolver
uniprot_entry
EFNB1_MOUSE
resolver
uniprot_entry
Q544L9_MOUSE
resolver
amino_acid_sequence
MARPGQRWLSKWLVAMVVLTLCRLATPLAKNLEPVSWSSLNPKFLSGKGLVIYPKIGDKLDIICPRAEAGRPYEYYKLYLVRPEQAAACSTVLDPNVLVTCNKPHQEIRFTIKFQEFSPNYMGLEFKKYHDYYITSTSNGSLEGLENREGGVCRTRTMKIVMKVGQDPNAVTPEQLTTSRPSKESDNTVKTATQAPGRGSQGDSDGKHETVNQEEKSGPGAGGGGSGDSDSFFNSKVALFAAVGAGCVIFLLIIIFLTVLLLKLRKRHRKHTQQRAAALSLSTLASPKGGSGTAGTEPSDIIIPLRTTENNYCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
uniprot
proteins
function
FUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:10704386, PubMed:7929389). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:10704386, PubMed:7929389). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (By similarity). Can also bind EPHB2 and EPHB3 (PubMed:7929389). Binds to, and induces the collapse of, commissural axons/growth cones in vitro (PubMed:10704386). May play a role in constraining the orientation of longitudinally projecting axons (PubMed:10704386). {ECO:0000250|UniProtKB:P98172, ECO:0000269|PubMed:10704386, ECO:0000269|PubMed:7929389}.
uniprot
proteins
mass_dalton
37859
uniprot
proteins
post_translational_modification
PTM: Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. {ECO:0000250|UniProtKB:P98172}.; PTM: Proteolytically processed. The ectodomain is cleaved, probably by a metalloprotease, to produce a membrane-tethered C-terminal fragment. This fragment is then further processed by the gamma-secretase complex to yield a soluble intracellular domain peptide which can translocate to the nucleus. The intracellular domain peptide is highly labile suggesting that it is targeted for degradation by the proteasome. {ECO:0000250|UniProtKB:P98172}.
uniprot
proteins
protein_family
Ephrin family
uniprot
proteins
pubmed
10197531
uniprot
proteins
pubmed
10704386
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
19515908
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21429299
uniprot
proteins
pubmed
27446912
uniprot
proteins
pubmed
7649373
uniprot
proteins
pubmed
7896266
uniprot
proteins
pubmed
7929389
uniprot
proteins
sequence_length
345
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7929389, ECO:0000305|PubMed:10704386}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:10197531}. Note=May recruit GRIP1 and GRIP2 to membrane raft domains. {ECO:0000269|PubMed:10197531}.; SUBCELLULAR LOCATION: [Ephrin-B1 C-terminal fragment]: Cell membrane {ECO:0000250|UniProtKB:P98172}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Ephrin-B1 intracellular domain]: Nucleus {ECO:0000269|PubMed:19515908}. Note=Colocalizes with ZHX2 in the nucleus. {ECO:0000269|PubMed:19515908}.
uniprot
proteins
transmembrane_region
TRANSMEM 237..257; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins