Treml4
entrez
224840
canonical
uniprot
Q3LRV9
canonical
ensembl
ENSMUSG00000051682
resolver
ensp
ENSMUSP00000054121
resolver
ensp
ENSMUSP00000115290
resolver
ensp
ENSMUSP00000118772
resolver
ensp
ENSMUSP00000119177
resolver
ensp
ENSMUSP00000120550
resolver
enst
ENSMUST00000136272
resolver
enst
ENSMUST00000154335
resolver
genesymbol
Treml4
resolver
genesymbol_syn
TLT4
resolver
genesymbol_syn
Treml3
resolver
uniprot
A6XA78
resolver
uniprot
D3YY88
resolver
uniprot
D3YYN5
resolver
uniprot
E9Q825
resolver
uniprot
Q3LRW0
resolver
uniprot_entry
D3YY88_MOUSE
resolver
uniprot_entry
D3YYN5_MOUSE
resolver
uniprot_entry
TRML4_MOUSE
resolver
uniprot_sec
A6XA78
resolver
uniprot_sec
E9Q825
resolver
uniprot_sec
Q3LRW0
resolver
amino_acid_sequence
MAWRYSQLLLVPVQLVFLASVCCPGVWGSTVSEELHRMVGQSLSVQCQYKPKEESYVLKTWCRQTAPSKCTRVVTTSEPRKAARELQHTIWDDPEAGFFNITMTQLTEDDSAFYWCGPYYPSLREVTVLRNISLVVSPAPSTLPSQTIAPLPESTATIFMPFPVLTTSPEETTDSSINGTGHRNQSSSSPGWTSPGLLVSVQYGLLLLKALMLSVFCVLLCWRSGQGREYMAETMELSKLPHISKSLDTVSHISGYEKKANWY
uniprot
proteins
function
FUNCTION: Positively regulates Toll-like receptor signaling via TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages (PubMed:25848864). Regulates TLR7 signaling by controlling ligand-induced recruitment of TLR7 from the endoplasmic reticulum to endosomes and lysosomes (PubMed:25848864). Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production (PubMed:25848864). Involved in the anti-viral response to several viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus (PubMed:25848864). Binds to late apoptotic, and necrotic cells, but not living or early apoptotic cells, but is not essential for uptake of dying cells by dendritic cells (DCs) (PubMed:19155473, PubMed:22210914, PubMed:25848864). Does not bind nucleic acids (PubMed:25848864). May participate in antigen presentation (PubMed:22210914). {ECO:0000269|PubMed:19155473, ECO:0000269|PubMed:22210914, ECO:0000269|PubMed:25848864}.
uniprot
proteins
mass_dalton
29355
uniprot
proteins
mutagenesis
MUTAGEN 209; /note="K->L: Loss of TLR7 signaling."; /evidence="ECO:0000269|PubMed:25848864
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19155473
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22210914
uniprot
proteins
pubmed
25848864
uniprot
proteins
sequence_length
263
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:19155473, ECO:0000305|PubMed:22210914}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 201..221; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins