PUM2
entrez
23369
canonical
uniprot
Q8TB72
canonical
ensembl
ENSG00000055917
resolver
ensp
ENSP00000354370
resolver
ensp
ENSP00000409905
resolver
ensp
ENSP00000516061
resolver
ensp
ENSP00000569178
resolver
ensp
ENSP00000569179
resolver
ensp
ENSP00000569181
resolver
ensp
ENSP00000569182
resolver
ensp
ENSP00000569185
resolver
ensp
ENSP00000569186
resolver
ensp
ENSP00000569190
resolver
ensp
ENSP00000569191
resolver
ensp
ENSP00000569193
resolver
ensp
ENSP00000569196
resolver
ensp
ENSP00000569197
resolver
ensp
ENSP00000569199
resolver
ensp
ENSP00000569201
resolver
ensp
ENSP00000569202
resolver
ensp
ENSP00000589085
resolver
ensp
ENSP00000589089
resolver
ensp
ENSP00000625829
resolver
ensp
ENSP00000780494
resolver
ensp
ENSP00000780497
resolver
genesymbol
PUM2
resolver
genesymbol_syn
KIAA0235
resolver
genesymbol_syn
PUMH2
resolver
hgnc
HGNC:14958
resolver
uniprot
B3KSL0
resolver
uniprot
B4E2B6
resolver
uniprot
B7ZL34
resolver
uniprot
D6W527
resolver
uniprot
O00234
resolver
uniprot
Q53TV7
resolver
uniprot
Q8WY43
resolver
uniprot
Q9HAN2
resolver
uniprot_entry
B7ZL34_HUMAN
resolver
uniprot_entry
PUM2_HUMAN
resolver
uniprot_sec
B3KSL0
resolver
uniprot_sec
B4E2B6
resolver
uniprot_sec
D6W527
resolver
uniprot_sec
O00234
resolver
uniprot_sec
Q53TV7
resolver
uniprot_sec
Q8WY43
resolver
uniprot_sec
Q9HAN2
resolver
amino_acid_sequence
MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGASHHSMSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGLGVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNALTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQQAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAANPTLAFGQGLATGMPGYQVLAPTAYYDQTGALVVGPGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAGGTASSLTGSTNGLFRPIGTQPPQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFSHGPGQPGSTSLGFGSGNSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYKRSSSSLAPIGQPFYNSLGFSSSPSPIGMPLPSQTPGHSLTPPPSLSSHGSSSSLHLGGLTNGSGRYISAAPGAEAKYRSASSTSSLFSSSSQLFPPSRLRYNRSDIMPSGRSRLLEDFRNNRFPNLQLRDLIGHIVEFSQDQHGSRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQMYGCRVIQKALESISSDQQVISEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKDQYANYVVQKMIDMAEPAQRKIIMHKIRPHITTLRKYTYGKHILAKLEKYYLKNSPDLGPIGGPPNGML
uniprot
proteins
function
FUNCTION: Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}.
uniprot
proteins
mass_dalton
114216
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12459267
uniprot
proteins
pubmed
12511597
uniprot
proteins
pubmed
12690449
uniprot
proteins
pubmed
12771951
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18776931
uniprot
proteins
pubmed
19168546
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21397187
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21800163
uniprot
proteins
pubmed
22345517
uniprot
proteins
pubmed
22955276
uniprot
proteins
pubmed
23125361
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25340845
uniprot
proteins
pubmed
25349211
uniprot
proteins
pubmed
26724866
uniprot
proteins
pubmed
28431233
uniprot
proteins
pubmed
9039502
uniprot
proteins
sequence_length
1066
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:19168546}. Cytoplasmic granule {ECO:0000269|PubMed:25340845}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19168546}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules. Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells. {ECO:0000269|PubMed:25340845}.
uniprot
proteins