Gpr137b
entrez
83924
canonical
uniprot
Q8BNQ3
canonical
ensembl
ENSMUSG00000021306
resolver
ensp
ENSMUSP00000021738
resolver
ensp
ENSMUSP00000152434
resolver
ensp
ENSMUSP00000152494
resolver
enst
ENSMUST00000021738
resolver
enst
ENSMUST00000220628
resolver
enst
ENSMUST00000223093
resolver
genesymbol
Gpr137b
resolver
genesymbol_syn
Tm7sf1
resolver
uniprot
A0A0R4J022
resolver
uniprot
A0A1Y7VLJ5
resolver
uniprot
Q3T9U4
resolver
uniprot
Q99LK4
resolver
uniprot
Q9JHD9
resolver
uniprot_entry
A0A0R4J022_MOUSE
resolver
uniprot_entry
A0A1Y7VLJ5_MOUSE
resolver
uniprot_entry
G137B_MOUSE
resolver
uniprot_sec
Q3T9U4
resolver
uniprot_sec
Q99LK4
resolver
uniprot_sec
Q9JHD9
resolver
amino_acid_sequence
MEAPPWEPVRNDSLPPTLSPAVPPYVKLGLTAVYTVFYALLFVFIYAQLWLVLRYRHKRLSYQSVFLFLCLFWASLRTVLFSFYFRDFVAANSFSPFVFWLLYCFPVCLQFFTLTLMNLYFTQVIFKAKSKYSPELLKYRLPLYLASLFISLVFLLVNLTCAVLVKTGDWDRKVIVSVRVAINDTLFVLCAISLSICLYKISKMSLANIYLESKGSSVCQVTAIGVTVILLYTSRACYNLFILSFSQIKNVHSFDYDWYNVSDQADLKSQLGDAGYVVFGVVLFVWELLPTTLVVYFFRVRNPTKDLTNPGMVPSHGFSPRSYFFDNPRRYDSDDDLAWNIAPQGLQGSFAPDYCDWGQQNNSFLAQAGTLHQDSTLDPDKASQG
uniprot
proteins
function
FUNCTION: Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomal localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Also acts as a negative regulator of osteoclast activity (PubMed:31173907). Involved in interleukin-4-induced M2 macrophage polarization (PubMed:30595385). {ECO:0000250|UniProtKB:O60478, ECO:0000269|PubMed:30595385, ECO:0000269|PubMed:31173907}.; FUNCTION: Also acts as a negative regulator of osteoclast activity (PubMed:31173907). Involved in interleukin-4-induced M2 macrophage polarization (PubMed:30595385). {ECO:0000269|PubMed:30595385, ECO:0000269|PubMed:31173907}.
uniprot
proteins
mass_dalton
44055
uniprot
proteins
protein_family
GPR137 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
30595385
uniprot
proteins
pubmed
31173907
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:31173907}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalized with MTOR in lysosome after amino acid stimulation. {ECO:0000250|UniProtKB:O60478}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..53; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 65..85; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 97..117; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 145..165; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 174..194; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 223..243; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 278..298; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins