Cltrn
entrez
57394
canonical
uniprot
Q9ESG4
canonical
ensembl
ENSMUSG00000015401
resolver
ensp
ENSMUSP00000015545
resolver
ensp
ENSMUSP00000107899
resolver
enst
ENSMUST00000015545
resolver
enst
ENSMUST00000112280
resolver
genesymbol
Cltrn
resolver
genesymbol_syn
Nx17
resolver
genesymbol_syn
Tmem27
resolver
uniprot
Q3UFF6
resolver
uniprot_entry
CLTRN_MOUSE
resolver
uniprot_sec
Q3UFF6
resolver
amino_acid_sequence
MLWALFFLVTTIHAELCHPDAENAFKVRLSIRAALGDKAYVWDTDQEYLFRAMVAFSMRKVPNREATEISHVLLCNITQRVSFWFVVTDPSNNYTLPAAEVQSAIRKNRNRINSAFFLDDHTLEFLKIPSTLAPPMEPSVPVWIIVFGVIFCIVTVAIALLVLSGIRQRRRNNKGPPGVEDAEDKCENIITIENGIPCDPLDMKGGHINDGFLTEDERLTPL
uniprot
proteins
function
FUNCTION: Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity (PubMed:16985211, PubMed:17167413). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (PubMed:16985211). Regulator of SNARE complex function (PubMed:16330323). Stimulator of beta cell replication (PubMed:16330324). {ECO:0000269|PubMed:16330323, ECO:0000269|PubMed:16330324, ECO:0000269|PubMed:16985211, ECO:0000269|PubMed:17167413}.
uniprot
proteins
mass_dalton
25070
uniprot
proteins
post_translational_modification
PTM: Glycosylated. Glycosylation is required for plasma membrane localization and for its cleavage by BACE2. {ECO:0000250|UniProtKB:Q9HBJ8}.; PTM: Proteolytically processed in pancreatic beta cells by BACE2 leading to the generation and extracellular release of soluble CLTRN, and a corresponding cell-associated C-terminal fragment which is later cleaved by gamma-secretase (PubMed:16330324, PubMed:21907142). This shedding process inactivates CLTRN (PubMed:16330324). Three cleavage sites have been identified for BACE2, two clustered sites after Phe-116 and Leu-118 and a more membrane proximal site at Phe-125; the preferred BACE2 cleavage site seems to be between Phe-125 and Leu-126, Phe-116 and Leu-118 act as alternative sites (By similarity). {ECO:0000250|UniProtKB:Q9HBJ8, ECO:0000269|PubMed:16330324, ECO:0000269|PubMed:21907142}.
uniprot
proteins
protein_family
CLTRN family
uniprot
proteins
pubmed
10432394
uniprot
proteins
pubmed
11278314
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16330323
uniprot
proteins
pubmed
16330324
uniprot
proteins
pubmed
16985211
uniprot
proteins
pubmed
17167413
uniprot
proteins
pubmed
19478081
uniprot
proteins
pubmed
19715677
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21907142
uniprot
proteins
pubmed
31520464
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16330324, ECO:0000269|PubMed:17167413}; Single-pass type I membrane protein {ECO:0000255}. Note=Localizes to the brush border membranes of cells in the proximal tubules of kidney (PubMed:17167413). Colocalizes with SLC6A19 in the early proximal S1 tubule (PubMed:17167413). {ECO:0000269|PubMed:17167413}.
uniprot
proteins
transmembrane_region
TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01354
uniprot
proteins