SPTSSB
entrez
165679
canonical
uniprot
Q8NFR3
canonical
ensembl
ENSG00000196542
resolver
ensp
ENSP00000352097
resolver
ensp
ENSP00000420115
resolver
ensp
ENSP00000480827
resolver
ensp
ENSP00000556360
resolver
ensp
ENSP00000605697
resolver
ensp
ENSP00000611758
resolver
ensp
ENSP00000611759
resolver
enst
ENST00000359175
resolver
enst
ENST00000497137
resolver
enst
ENST00000620149
resolver
enst
ENST00000886301
resolver
enst
ENST00000935638
resolver
enst
ENST00000941699
resolver
enst
ENST00000941700
resolver
genesymbol
C3orf57
resolver
genesymbol
SPTSSB
resolver
genesymbol_syn
ADMP
resolver
genesymbol_syn
C3orf57
resolver
genesymbol_syn
SSSPTB
resolver
hgnc
HGNC:24045
resolver
uniprot
B2R5D3
resolver
uniprot
D3DNM8
resolver
uniprot
Q0P5S6
resolver
uniprot
Q6ZWB5
resolver
uniprot_entry
Q6ZWB5_HUMAN
resolver
uniprot_entry
SPTSB_HUMAN
resolver
uniprot_sec
B2R5D3
resolver
uniprot_sec
D3DNM8
resolver
uniprot_sec
Q0P5S6
resolver
amino_acid_sequence
MDLRRVKEYFSWLYYQYQIISCCAVLEPWERSMFNTILLTIIAMVVYTAYVFIPIHIRLAWEFFSKICGYHSTISN
uniprot
proteins
function
FUNCTION: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases (PubMed:19416851). The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core (PubMed:19416851). Within the SPT complex, SPTSSB stimulates the catalytic activity and plays a role in substrate specificity. SPT complexes with this subunit showing a preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (PubMed:19416851). {ECO:0000269|PubMed:19416851}.
uniprot
proteins
mass_dalton
9198
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism.
uniprot
proteins
protein_family
SPTSS family
uniprot
proteins
protein_family
SPTSSB subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15777716
uniprot
proteins
pubmed
19416851
uniprot
proteins
sequence_length
76
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 37..57; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins