H1-5
entrez
56702
canonical
uniprot
P43276
canonical
ensembl
ENSMUSG00000058773
resolver
ensp
ENSMUSP00000079356
resolver
enst
ENSMUST00000080511
resolver
genesymbol
H1-5
resolver
genesymbol_syn
H1f5
resolver
genesymbol_syn
Hist1h1b
resolver
uniprot
Q9CRM8
resolver
uniprot_entry
H15_MOUSE
resolver
uniprot_sec
Q9CRM8
resolver
amino_acid_sequence
MSETAPAETAAPAPVEKSPAKKKTTKKAGAAKRKATGPPVSELITKAVSASKERGGVSLPALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKAKKTGAAKAKKPAGATPKKPKKTAGAKKTVKKTPKKAKKPAAAGVKKVAKSPKKAKAAAKPKKAAKSPAKPKAVKSKASKPKVTKPKTAKPKAAKAKKAVSKKK
uniprot
proteins
function
FUNCTION: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. {ECO:0000250|UniProtKB:P10412}.
uniprot
proteins
mass_dalton
22576
uniprot
proteins
post_translational_modification
PTM: Deamidation of Asn-76 and Asn-77 by CTPS1 in response to DNA damage promotes subsequent acetylation of histone H1 at Lys-75 (H1K75ac). {ECO:0000250|UniProtKB:P10412}.; PTM: Acetylated at Lys-75 (H1K75ac) by EP300 following deamidation of Asn-76 and Asn-77 by CTPS1 in response to DNA damage, thereby increasing chromatin accessibility to facilitate the recruitment of DNA repair proteins. {ECO:0000250|UniProtKB:P10412}.; PTM: H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter. {ECO:0000250|UniProtKB:P16401}.; PTM: Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. {ECO:0000269|PubMed:24463520}.; PTM: Hydroxybutyrylation of histones is induced by starvation. {ECO:0000250|UniProtKB:P43277}.
uniprot
proteins
protein_family
Histone H1/H5 family
uniprot
proteins
pubmed
12408966
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16600910
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24463520
uniprot
proteins
pubmed
28539972
uniprot
proteins
pubmed
8589518
uniprot
proteins
pubmed
8858344
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P16401}. Chromosome {ECO:0000250|UniProtKB:P16401}. Note=Enriched at the nuclear periphery and colocalizes with compacted DNA (heterochromatin). Also associates with actively transcribed chromatin. {ECO:0000250|UniProtKB:P16401}.
uniprot
proteins