Bglap2
entrez
12097
canonical
uniprot
P86547
canonical
ensembl
ENSMUSG00000074486
resolver
ensp
ENSMUSP00000096555
resolver
enst
ENSMUST00000098956
resolver
genesymbol
Bglap2
resolver
uniprot
P04641
resolver
uniprot_entry
OSTC2_MOUSE
resolver
uniprot_sec
P04641
resolver
amino_acid_sequence
MRTLSLLTLLALAALCLSDLTDAKPSGPESDKAFMSKQEGNKVVNRLRRYLGASVPSPDPLEPTREQCELNPACDELSDQYGLKTAYKRIYGITI
uniprot
proteins
function
FUNCTION: The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein: it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization (PubMed:8684484). The carboxylated form binds strongly to apatite and calcium (PubMed:17693256). {ECO:0000269|PubMed:17693256, ECO:0000269|PubMed:8684484}.; FUNCTION: The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development (PubMed:17693256, PubMed:20655470, PubMed:20655471, PubMed:21333348, PubMed:24074871). Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure (PubMed:17693256, PubMed:20655470, PubMed:20655471). Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (PubMed:21333348). Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA) (PubMed:24074871, PubMed:28851741). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development (PubMed:24074871). {ECO:0000269|PubMed:17693256, ECO:0000269|PubMed:20655470, ECO:0000269|PubMed:20655471, ECO:0000269|PubMed:21333348, ECO:0000269|PubMed:24074871, ECO:0000269|PubMed:28851741}.
uniprot
proteins
mass_dalton
10459
uniprot
proteins
post_translational_modification
PTM: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation by GGCX (By similarity). These residues are essential for the binding of calcium (By similarity). Carboxylated in a Ptprv/Esp-dependent process (PubMed:17693256, PubMed:20655470, PubMed:20655471). Decarboxylation promotes the hormone activity (PubMed:17693256, PubMed:20655470, PubMed:20655471, PubMed:21333348, PubMed:24074871). {ECO:0000250|UniProtKB:P02818, ECO:0000269|PubMed:17693256, ECO:0000269|PubMed:20655470, ECO:0000269|PubMed:20655471, ECO:0000269|PubMed:21333348, ECO:0000269|PubMed:24074871}.
uniprot
proteins
protein_family
Osteocalcin/matrix Gla protein family
uniprot
proteins
pubmed
17693256
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20655470
uniprot
proteins
pubmed
20655471
uniprot
proteins
pubmed
21333348
uniprot
proteins
pubmed
24074871
uniprot
proteins
pubmed
28851741
uniprot
proteins
pubmed
3019668
uniprot
proteins
pubmed
8243336
uniprot
proteins
pubmed
8288580
uniprot
proteins
pubmed
8684484
uniprot
proteins
sequence_length
95
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17693256, ECO:0000269|PubMed:20655470, ECO:0000269|PubMed:20655471, ECO:0000269|PubMed:21333348, ECO:0000269|PubMed:24074871}.
uniprot
proteins