Ldlrad4
entrez
52662
canonical
uniprot
Q8BWJ4
canonical
ensembl
ENSMUSG00000024544
resolver
ensp
ENSMUSP00000068471
resolver
ensp
ENSMUSP00000315422
resolver
ensp
ENSMUSP00000315423
resolver
ensp
ENSMUSP00000315426
resolver
ensp
ENSMUSP00000315427
resolver
ensp
ENSMUSP00000315428
resolver
ensp
ENSMUSP00000315431
resolver
ensp
ENSMUSP00000315432
resolver
enst
ENSMUST00000063775
resolver
genesymbol
Ldlrad4
resolver
genesymbol_syn
D18Ertd653e
resolver
uniprot
Q4VAH9
resolver
uniprot
Q8BYE2
resolver
uniprot_entry
LRAD4_MOUSE
resolver
uniprot_entry
Q4VAH9_MOUSE
resolver
uniprot_entry
Q8BYE2_MOUSE
resolver
amino_acid_sequence
MPEAGFQATNAFTECKFTCTSGKCLYLGSLVCNQQNDCGDNSDEENCLLVTEHPPPGIFNSELEFAQILIIVVVVTVMVVVVVCLLNHYKVSTRSFINRPNQSQRQEDGLQPEGSLWPSDSSVQRPGASEIMCAPRGRDRFTTPSFIQRDPFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTVFDSDLIDISMYNGGPCPPSSHSGISAATCSSNGRMEGPPPTYSEVMGHYPGTSFFHHQHSNTHRGSRPQFQPNNSEGTIVPIKGKDRKPGDLV
uniprot
proteins
function
FUNCTION: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. {ECO:0000269|PubMed:24627487}.
uniprot
proteins
mass_dalton
33857
uniprot
proteins
protein_family
PMEPA1 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24627487
uniprot
proteins
sequence_length
306
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 65..85; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins