Rdh12
entrez
77974
canonical
uniprot
Q8BYK4
canonical
ensembl
ENSMUSG00000021123
resolver
ensp
ENSMUSP00000021548
resolver
ensp
ENSMUSP00000112543
resolver
enst
ENSMUST00000021548
resolver
enst
ENSMUST00000122227
resolver
genesymbol
Rdh12
resolver
uniprot
A0A0R4J1M3
resolver
uniprot
Q91WA5
resolver
uniprot
Q9D1Y4
resolver
uniprot_entry
A0A0R4J1M3_MOUSE
resolver
uniprot_entry
RDH12_MOUSE
resolver
uniprot_sec
Q91WA5
resolver
uniprot_sec
Q9D1Y4
resolver
amino_acid_sequence
MLFILVLLTSFLSILYLTAPSIRKFFAGGVCTTNVQIPGKVVVITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIRADTKNSQVLVRKLDLSDTKSIRAFAERFLAEEKKLHILINNAGVMMCPYSKTTDGFETHFGVNHLGHFLLTYLLLERLKESAPARVVNLSSIAHLIGKIRFHDLQGQKRYCSAFAYGHSKLANLLFTRELAKRLQGTGVTAYAVHPGVVLSEITRNSYLLCLLWRLFSPFFKSTSQGAQTSLHCALAEDLEPLSGKYFSDCKRMWVSSRARNKKTAERLWNVSCELLGIQWE
uniprot
proteins
ec_number
1.1.1.300
uniprot
proteins
function
FUNCTION: Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity toward 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal (By similarity). Plays an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:17032653, PubMed:19686838, PubMed:22621924). Has no dehydrogenase activity towards steroids (By similarity). {ECO:0000250|UniProtKB:Q96NR8, ECO:0000269|PubMed:17032653, ECO:0000269|PubMed:19686838, ECO:0000269|PubMed:22621924}.
uniprot
proteins
mass_dalton
35292
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000250|UniProtKB:Q96NR8}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
12226107
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17032653
uniprot
proteins
pubmed
19686838
uniprot
proteins
pubmed
22621924
uniprot
proteins
sequence_length
316
uniprot
proteins