EXOSC4
entrez
54512
canonical
uniprot
Q9NPD3
canonical
ensembl
ENSG00000178896
resolver
ensp
ENSP00000315476
resolver
enst
ENST00000316052
resolver
genesymbol
EXOSC4
resolver
genesymbol_syn
RRP41
resolver
genesymbol_syn
SKI6
resolver
hgnc
HGNC:18189
resolver
uniprot_entry
EXOS4_HUMAN
resolver
amino_acid_sequence
MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEIRGSRARALPDRALVNCQYSSATFSTGERKRRPHGDRKSCEMGLQLRQTFEAAILTQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRDFVCACSAGFVDGTALADLSHVEEAAGGPQLALALLPASGQIALLEMDARLHEDHLERVLEAAAQAARDVHTLLDRVVRQHVREASILLGD
uniprot
proteins
function
FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs. {ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:21255825}.
uniprot
proteins
mass_dalton
26383
uniprot
proteins
protein_family
RNase PH family
uniprot
proteins
pubmed
10465791
uniprot
proteins
pubmed
11110791
uniprot
proteins
pubmed
11719186
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16912217
uniprot
proteins
pubmed
17174896
uniprot
proteins
pubmed
17545563
uniprot
proteins
pubmed
18172165
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20368444
uniprot
proteins
pubmed
20531389
uniprot
proteins
pubmed
21255825
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21791617
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
29906447
uniprot
proteins
pubmed
30047866
uniprot
proteins
pubmed
36912080
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:36912080}. Nucleus, nucleolus {ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:36912080}. Nucleus {ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:36912080}. Nucleus, nucleoplasm {ECO:0000269|PubMed:36912080}.
uniprot
proteins