IFI27
entrez
3429
canonical
uniprot
P40305
canonical
ensembl
ENSG00000165949
resolver
ensembl
ENSG00000275214
resolver
ensp
ENSP00000477753
resolver
ensp
ENSP00000482635
resolver
ensp
ENSP00000483430
resolver
ensp
ENSP00000483498
resolver
ensp
ENSP00000528947
resolver
ensp
ENSP00000528951
resolver
ensp
ENSP00000766620
resolver
genesymbol
IFI27
resolver
hgnc
HGNC:5397
resolver
uniprot
A0A087WZF8
resolver
uniprot
A8K0H0
resolver
uniprot
Q53YA6
resolver
uniprot
Q6IEC1
resolver
uniprot
Q7Z5R0
resolver
uniprot
Q7Z5R1
resolver
uniprot
Q7Z5R2
resolver
uniprot
Q96BK3
resolver
uniprot
Q9H4B1
resolver
uniprot_entry
IFI27_HUMAN
resolver
uniprot_sec
A0A087WZF8
resolver
uniprot_sec
A8K0H0
resolver
uniprot_sec
Q53YA6
resolver
uniprot_sec
Q6IEC1
resolver
uniprot_sec
Q7Z5R0
resolver
uniprot_sec
Q7Z5R1
resolver
uniprot_sec
Q7Z5R2
resolver
uniprot_sec
Q96BK3
resolver
uniprot_sec
Q9H4B1
resolver
amino_acid_sequence
MEASALTSSAVTSVAKVVRVASGSAVVLPLARIATVVIGGVVAMAAVPMVLSAMGFTAAGIASSSIAAKMMSAAAIANGGGVASGSLVATLQSLGATGLSGLTKFILGSIGSAIAAVIARFY
uniprot
proteins
function
FUNCTION: Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766). Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:24970806, PubMed:27673746). Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746). Also functions in TNFSF10-induced apoptosis (PubMed:24970806). May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077). May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077). Also promotes virus-induced pyroptosis by activating CASP3 in the mitochondria after 'Lys-6'-linked ubiquitination by TRIM21 (PubMed:36426955). {ECO:0000250|UniProtKB:Q8R412, ECO:0000269|PubMed:18330707, ECO:0000269|PubMed:22427340, ECO:0000269|PubMed:24970806, ECO:0000269|PubMed:27194766, ECO:0000269|PubMed:27673746, ECO:0000269|PubMed:27777077, ECO:0000269|PubMed:36426955}.
uniprot
proteins
mass_dalton
11542
uniprot
proteins
mutagenesis
MUTAGEN 56; /note="F->D: Increased pro-apoptotic activity; when associated with D-96."; /evidence="ECO:0000269|PubMed:27673746"; MUTAGEN 69; /note="K->R: Complete loss of TRIM21-mediated ubiquitination."; /evidence="ECO:0000269|PubMed:36426955"; MUTAGEN 96; /note="A->D: Increased pro-apoptotic activity; when associated with D-56."; /evidence="ECO:0000269|PubMed:27673746
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by TRIM21 via 'Lys-6'-linked ubiquitin chains leading to IFI27 mitochondrial migration. {ECO:0000269|PubMed:36426955}.
uniprot
proteins
protein_family
IFI6/IFI27 family
uniprot
proteins
pubmed
11722583
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12878323
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14728724
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18330707
uniprot
proteins
pubmed
22427340
uniprot
proteins
pubmed
24970806
uniprot
proteins
pubmed
27194766
uniprot
proteins
pubmed
27673746
uniprot
proteins
pubmed
27777077
uniprot
proteins
pubmed
36426955
uniprot
proteins
pubmed
8358738
uniprot
proteins
sequence_length
122
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:18330707, ECO:0000269|PubMed:27673746, ECO:0000269|PubMed:36426955}; Multi-pass membrane protein {ECO:0000255}. Nucleus inner membrane {ECO:0000269|PubMed:11722583, ECO:0000269|PubMed:22427340}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22427340}; Multi-pass membrane protein {ECO:0000255}. Note=Exclusive localizations in either the nucleus or the mitochondrion have been reported. {ECO:0000269|PubMed:22427340, ECO:0000269|PubMed:27673746, ECO:0000269|PubMed:36426955}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..57; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 99..119; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins