Q6Q473
uniprot
Q6Q473
canonical
amino_acid_sequence
MAFSRGPVFLLLLLYLLWGSDTSLIRLNENGYEDIIIAIDPAVPEDTTIIEHIKGMVTKASTYLFEATEKRFFFKNVSILIPESWKDSPQYRRPKQESYKHADIKVAPPTVEGRDEPYTRQFTQCEEKAEYIHFTPDFVLGRKQDEYGDSGKVLVHEWAHLRWGVFDEYNEDQPFYSASSKKIEATRCSTGITGTNRVYACQGGSCAMRRCRTNSTTKLYEKDCQFFPDKVQSEKASIMFMQSIDSVTEFCKKENHNREAPTLHNKKCNYRSTWEVISTSEDFNSSTPMETSPSPPFFSLLRISERIMCLVLDVSGSMTSYDRLNRMNQAAKYFLSQIIENRSWVGMVHFSSQATIVHELIQINSDIERNQLLQTLPTSANGGTSICSGIKAAFQVFKNGEYQTDGTEILLLSDGEDSTAKDCIDEVKDSGSIVHFIALGPLADLAVTNMSILTGGNHKLATDEAQNNGLIDAFGALASENADITQKSLQLESKGAILNNSLWLNDTVVIDSTLGRDTFFLVTWSKQAPAIYLRDPKGTQTTNFTMDSASKMAYLSIPGTAQVGVWTYNLEAKENSEILTITVTSRAANSSVPPITVNAKVNTDTNTFPSPMIVYAEVLQGYTPIIGARVTATIESNSGKTEELVLLDNGAGADAFKDDGVYSRFFTAYSVNGRYSLKVRADGGRNSARRSLRHPSSRAAYIPGWVVDGEIQGNPPRPETTEATQPVLENFSRTASGGAFVVSNVPSGPLPDLYPPNQITDLQATLDGEEISLTWTAPGDDYDVGRVQQYIIRTSKNIIELRDNFNNSPRVDTTNLTPKEANSEETFAFKPENITEENATYIFIAIESVDKSSLSSGPSNIAQVALFTPQAEPDPDESPSSSGVSVATIVLSVLGALVLVCIIVGTTICILKNKRSSSAAITKF
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: May be involved in mediating calcium-activated chloride conductance. {ECO:0000269|PubMed:15284223, ECO:0000269|PubMed:18285349}.
uniprot
proteins
mass_dalton
101872
uniprot
proteins
post_translational_modification
PTM: N-Glycosylated. {ECO:0000269|PubMed:15284223, ECO:0000269|PubMed:18285349}.; PTM: The translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a N-terminal and a C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. {ECO:0000250|UniProtKB:A8K7I4}.
uniprot
proteins
protein_family
CLCR family
uniprot
proteins
pubmed
15284223
uniprot
proteins
pubmed
18285349
uniprot
proteins
sequence_length
924
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein. Apical cell membrane. Secreted. Note=The C-terminus 30 kDa form is anchored to the membrane. The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus. Associated with the microvilli of non-goblet cell enterocytes in the small and large intestine. Colocalizes with CFTR.
uniprot
proteins
transmembrane_region
TRANSMEM 884..904; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins