Htr1f
entrez
15557
canonical
uniprot
Q02284
canonical
ensembl
ENSMUSG00000050783
resolver
ensp
ENSMUSP00000063136
resolver
enst
ENSMUST00000063076
resolver
genesymbol
Htr1f
resolver
genesymbol_syn
5ht1f
resolver
genesymbol_syn
Htr1eb
resolver
uniprot
Q543V2
resolver
uniprot_entry
5HT1F_MOUSE
resolver
uniprot_entry
Q543V2_MOUSE
resolver
amino_acid_sequence
MDFLNASDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVLCDIWLSVDIICCTCSILHLSAIALDRYRAITDAVEYARKRTPRHAGIMITIVWVISVFISMPPLFWRHQGTSRDDECVIKHDHIVSTIYSTFGAFYIPLVLILILYYKIYRAARTLYHKRQASRMIKEELNGQVFLESGEKSIKLVSTSYMLEKSLSDPSTDFDRIHSTVKSPRSELKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCEKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRY
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1328180). Also functions as a receptor for various alkaloids and psychoactive substances (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (By similarity). {ECO:0000250|UniProtKB:P30939, ECO:0000269|PubMed:1328180}.
uniprot
proteins
mass_dalton
41977
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1328180
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1328180}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30939}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..49; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P30939"; TRANSMEM 60..81; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P30939"; TRANSMEM 97..119; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P30939"; TRANSMEM 140..159; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P30939"; TRANSMEM 179..202; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P30939"; TRANSMEM 292..315; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P30939"; TRANSMEM 328..350; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P30939
uniprot
proteins