Dbh
entrez
13166
canonical
uniprot
Q64237
canonical
ensembl
ENSMUSG00000000889
resolver
ensp
ENSMUSP00000000910
resolver
enst
ENSMUST00000000910
resolver
genesymbol
Dbh
resolver
uniprot
Q3V1U4
resolver
uniprot_entry
DOPO_MOUSE
resolver
uniprot_sec
Q3V1U4
resolver
amino_acid_sequence
MQAHLSHQPCWSSLPSPSVREAASMYGTAVAIFLVILVAALRGSEPPESPFPYHIPLDPEGILELSWNVSYVQEIIHFQLQVQGLRAGVLFGMSDRGEMENADLIMLWTDGDRAYFADAWSDRKGQIHLDSQQDYQLLQAQRTRDGLSLLFKRPFVTCDPKDYVIEDDTVHLVYGILEEPFQSLEAINTSGLHTGLQRVQLLKSEVPTPSMPEDVQTMDIRAPDILIPDNETTYWCYITELPPRFPRHHIIMYEAIVTEGNEALVHHMEVFQCAAESEDFPQFNGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPKEAGVPFGGPGSSPFLRLEVHYHNPRKIQGRQDSSGIRLHYTATLRRYDAGIMELGLVYTPLMAIPPQETAFVLTGYCTDKCTQMALQDSGIHIFASQLHTHLTGRKVVTVLARDGQERKVVNRDNHYSPHFQEIRMLKKVVTVYPGDVLITSCTYNTENKTLATVGGFGILEEMCVNYVHYYPQTELELCKSAVDDGFLQKYFHMVNRFSSEEVCTCPQASVPQQFSSVPWNSFNRDMLKALYDYAPISMHCNKTSAVRFPGEWNLQPLPKITSTLEEPTPRCPIRQTQSPANPTVPITTEADAE
uniprot
proteins
ec_number
1.14.17.1
uniprot
proteins
function
FUNCTION: Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters. {ECO:0000269|PubMed:27148966, ECO:0000269|PubMed:7715704}.
uniprot
proteins
mass_dalton
70314
uniprot
proteins
pathway_participation
PATHWAY: Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1. {ECO:0000269|PubMed:27148966, ECO:0000269|PubMed:7715704}.
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form. {ECO:0000250|UniProtKB:P15101}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:P09172}.
uniprot
proteins
protein_family
Copper type II ascorbate-dependent monooxygenase family
uniprot
proteins
pubmed
1280432
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27148966
uniprot
proteins
pubmed
7715704
uniprot
proteins
pubmed
7961964
uniprot
proteins
sequence_length
622
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000269|PubMed:7961964}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen {ECO:0000269|PubMed:7961964}.; SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:7961964}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000269|PubMed:7961964}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins