Bmp5
entrez
12160
canonical
uniprot
P49003
canonical
ensembl
ENSMUSG00000032179
resolver
ensp
ENSMUSP00000012281
resolver
genesymbol
Bmp5
resolver
genesymbol_syn
Bmp-5
resolver
uniprot
Q3UXE6
resolver
uniprot
Q8CCE0
resolver
uniprot_entry
BMP5_MOUSE
resolver
uniprot_entry
Q3UXE6_MOUSE
resolver
uniprot_sec
Q8CCE0
resolver
amino_acid_sequence
MHWTVFLLRGIVGFLWSGWVQVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMASEDNPEEYLVRVSLAGEAKETRKGYPASPNGYAHRLHLPPRTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDKGNHRFENETIKISIYQIIKEYTNRDADLFLLDTRKTQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRHGPQSKQPFMVAFFKASEVLLRSVRAASKRKNQNRNKSNSHQDPSRMPSAGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
uniprot
proteins
function
FUNCTION: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed:29321139, PubMed:7958439). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (By similarity). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509). {ECO:0000250|UniProtKB:P22003, ECO:0000269|PubMed:29321139, ECO:0000269|PubMed:30097509, ECO:0000269|PubMed:7958439}.
uniprot
proteins
mass_dalton
51512
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
29321139
uniprot
proteins
pubmed
30097509
uniprot
proteins
pubmed
7958439
uniprot
proteins
sequence_length
452
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins