Sdccag8
entrez
76816
canonical
uniprot
Q80UF4
canonical
ensembl
ENSMUSG00000026504
resolver
ensp
ENSMUSP00000027785
resolver
ensp
ENSMUSP00000199307
resolver
ensp
ENSMUSP00000199308
resolver
ensp
ENSMUSP00000199314
resolver
enst
ENSMUST00000027785
resolver
genesymbol
Sdccag8
resolver
genesymbol_syn
Cccap
resolver
uniprot_entry
SDCG8_MOUSE
resolver
amino_acid_sequence
MAKSPGNSTLEDSLGQYQRSLRERANRSIHQLKCALREVDVTVEEDALDPSTSINVENEDTGVAWHELQHSHAVNQLKALLRQQTNKENETSPPRRRKLSPSRPSECDDGSMPTMHNLVPIINDQSQYIHHLEAEVKFCKDELSGMKNRVQVVVLENERLQQELKSQRPEETLREQTFLDASGNMQNSWIMTREDSRVDEAAKRPFSHGDAETGKTASTGDANKWKLELERLKLTYEAKTDLLESQLMLLRKDLAEYQKTCEDLKERLKHKESLLAASASSRVGGLCLKCAQHEAVLSQTHSNVHIQTIERLTKERDDLMSVLVSVRSSLAEAQKRETSAYEQVKHAVQMTEEANFEKTKALIQCEQLKSELERQTERLEKELASQQEKRAVEKEMIKKEVAREREDAESKMLILSQNIAKLEAQVEKVTREKTAAVSHLEEIQNHVASQEMDVTKVCGEMRFQLNKTKMEKDEVEKEHREYKAKSHKDLEMKVQEIEKLRLELSESEQHVEQEQQKAARARQECLRVTELLGEAERQLHLTRLEKDSIQQSFSNEAKAQALQAQQREQELTQKIQQMETQHDKTESEQYLLLTSQNTFLTKLKEECCLLAKKLEKVSLKSRSQIVRLSQEKRYLCDKLEKLQKRNDELEEQCIQHGRVHETMKERLRQLDKHGQATAQQLVQLLNKQNQLLLERQNLSEEVARLRAQLPSMPQSDC
uniprot
proteins
function
FUNCTION: Plays a role in the establishment of cell polarity and epithelial lumen formation (PubMed:20835237). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062). {ECO:0000269|PubMed:20835237, ECO:0000269|PubMed:27224062}.
uniprot
proteins
mass_dalton
82979
uniprot
proteins
pubmed
12559564
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20835237
uniprot
proteins
pubmed
27224062
uniprot
proteins
sequence_length
717
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:12559564, ECO:0000269|PubMed:20835237}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q86SQ7}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q86SQ7}. Cell junction {ECO:0000250|UniProtKB:Q86SQ7}. Note=Located at the distal ends of both centrioles and colocalizes to centrosomes throughout the cell cycle. {ECO:0000250|UniProtKB:Q86SQ7}.
uniprot
proteins