CHORDC1
entrez
26973
canonical
uniprot
Q9UHD1
canonical
ensembl
ENSG00000110172
resolver
ensembl
ENSG00000285023
resolver
ensp
ENSP00000319255
resolver
ensp
ENSP00000401080
resolver
ensp
ENSP00000436945
resolver
ensp
ENSP00000493836
resolver
ensp
ENSP00000784826
resolver
enst
ENST00000525317
resolver
enst
ENST00000644264
resolver
genesymbol
CHORDC1
resolver
genesymbol_syn
CHP1
resolver
hgnc
HGNC:14525
resolver
uniprot
B2R6P8
resolver
uniprot
E9PPQ5
resolver
uniprot
Q6IN49
resolver
uniprot
Q8WVL9
resolver
uniprot
Q9H3D6
resolver
uniprot_entry
CHRD1_HUMAN
resolver
uniprot_entry
E9PPQ5_HUMAN
resolver
uniprot_sec
B2R6P8
resolver
uniprot_sec
Q6IN49
resolver
uniprot_sec
Q8WVL9
resolver
uniprot_sec
Q9H3D6
resolver
amino_acid_sequence
MALLCYNRGCGQRFDPETNSDDACTYHPGVPVFHDALKGWSCCKRRTTDFSDFLSIVGCTKGRHNSEKPPEPVKPEVKTTEKKELCELKPKFQEHIIQAPKPVEAIKRPSPDEPMTNLELKISASLKQALDKLKLSSGNEENKKEEDNDEIKIGTSCKNGGCSKTYQGLESLEEVCVYHSGVPIFHEGMKYWSCCRRKTSDFNTFLAQEGCTKGKHMWTKKDAGKKVVPCRHDWHQTGGEVTISVYAKNSLPELSRVEANSTLLNVHIVFEGEKEFDQNVKLWGVIDVKRSYVTMTATKIEITMRKAEPMQWASLELPAAKKQEKQKDATTD
uniprot
proteins
function
FUNCTION: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105). Involved in stress response (PubMed:20230755). Prevents tumorigenesis (PubMed:20230755). {ECO:0000269|PubMed:20230755, ECO:0000269|PubMed:32053105}.
uniprot
proteins
mass_dalton
37490
uniprot
proteins
pubmed
10571178
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19875381
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20230755
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
32053105
uniprot
proteins
sequence_length
332
uniprot
proteins