Tspan5
entrez
56224
canonical
uniprot
P62080
canonical
ensembl
ENSMUSG00000028152
resolver
ensp
ENSMUSP00000029800
resolver
ensp
ENSMUSP00000113230
resolver
ensp
ENSMUSP00000113359
resolver
enst
ENSMUST00000029800
resolver
enst
ENSMUST00000119993
resolver
enst
ENSMUST00000121826
resolver
genesymbol
Tspan5
resolver
genesymbol_syn
Tm4sf9
resolver
uniprot
D3Z641
resolver
uniprot
O60628
resolver
uniprot
O60746
resolver
uniprot
Q9JLY1
resolver
uniprot_entry
D3Z641_MOUSE
resolver
uniprot_entry
TSN5_MOUSE
resolver
uniprot_sec
O60628
resolver
uniprot_sec
O60746
resolver
uniprot_sec
Q9JLY1
resolver
amino_acid_sequence
MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEKGVLSNISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRASW
uniprot
proteins
function
FUNCTION: Regulates ADAM10 maturation and trafficking to the cell surface (PubMed:23035126). Promotes ADAM10-mediated cleavage of CD44 (By similarity). {ECO:0000250|UniProtKB:P62079}.; FUNCTION: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:23035126). Promotes ADAM10-mediated cleavage of CD44. Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration (By similarity). {ECO:0000250|UniProtKB:P62079, ECO:0000269|PubMed:23035126}.
uniprot
proteins
mass_dalton
30337
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. {ECO:0000250|UniProtKB:P62079}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23035126
uniprot
proteins
pubmed
26668317
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P62079}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins