Fkbp5
entrez
14229
canonical
uniprot
Q64378
canonical
ensembl
ENSMUSG00000024222
resolver
ensp
ENSMUSP00000078382
resolver
ensp
ENSMUSP00000110440
resolver
ensp
ENSMUSP00000156418
resolver
enst
ENSMUST00000079413
resolver
enst
ENSMUST00000114792
resolver
enst
ENSMUST00000233102
resolver
genesymbol
Fkbp5
resolver
genesymbol_syn
Fkbp51
resolver
uniprot
Q4FJN2
resolver
uniprot_entry
FKBP5_MOUSE
resolver
uniprot_entry
Q4FJN2_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by both FK506 and rapamycin. {ECO:0000269|PubMed:7542743}.
uniprot
proteins
amino_acid_sequence
MTTDEGTSNNGENPAATMTEQGEDITTKKDRGVLKIVKRVGTSDEAPMFGDKVYVHYKGMLSDGKKFDSSHDRKKPFAFSLGQGQVIKAWDIGVSTMKKGEICHLLCKPEYAYGSAGHLQKIPSNATLFFEIELLDFKGEDLFEDSGVIRRIKRKGEGYSNPNEGATVKVHLEGCCGGRTFDCRDVVFVVGEGEDHDIPIGIDKALVKMQREEQCILYLGPRYGFGEAGKPKFGIDPNAELMYEVTLKSFEKAKESWEMDTKEKLTQAAIVKEKGTVYFKGGKYTQAVIQYRKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYNKAVECCDKALGLDSANEKGLYRRGEAQLLMNDFESAKGDFEKVLAVNPQNRAARLQISMCQRKAKEHNERDRRVYANMFKKFAERDAKEEASKAGSKKAVEGAAGKQHESQAMEEGKAKGHV
uniprot
proteins
ec_number
5.2.1.8
uniprot
proteins
function
FUNCTION: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production. {ECO:0000250|UniProtKB:Q13451}.
uniprot
proteins
mass_dalton
50966
uniprot
proteins
post_translational_modification
PTM: Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1. Deacetylation by SIRT7 promotes interaction between Akt/AKT1 and PHLPP1, leading to suppress Akt/AKT1 activation. {ECO:0000250|UniProtKB:Q13451}.; PTM: Ubiquitinated, leading to degradation in a proteasome-dependent manner. Deubiquitinated by USP49, leading to stabilization. {ECO:0000250|UniProtKB:Q13451}.
uniprot
proteins
pubmed
11751894
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21994940
uniprot
proteins
pubmed
7479941
uniprot
proteins
pubmed
7542743
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11751894}. Nucleus {ECO:0000269|PubMed:11751894}.
uniprot
proteins