Dok1
entrez
312477
canonical
uniprot
Q4QQV2
canonical
ensembl
ENSRNOG00000007412
resolver
ensp
ENSRNOP00000010020
resolver
genesymbol
Dok1
resolver
uniprot_entry
DOK1_RAT
resolver
amino_acid_sequence
MDGALMEGPLFLQSQRFGTKRWKKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGGSRRLDCKMIRLAECVSVVPVTVESPPEPGASAFRLDTAQRSHLLAADAASSTAWVQILCRTAFPKGGWALAQTENPPKFSALEMLENSLYSPTWEGSQFWVTSQKTEASERCGLQGSYVLRVEAEKLTLLTLGAQSQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVEAAIQQQKAQGKVGQGQDITRTDSHDGETEGKMAPTPVPQEPLGSPPALYAEPLDSLRIPPGPSQDSLYSDPLGSTPAGAGEGVQRKKPLYWDLYGHVQQQLLKTKLIDSKEDPIYDEPEGLAPAPLRGLYDLPQEPKDAWWCQARLKEEGYELPYNPATDDYAVPPPRSSKPTPAPKPQGLILPESGTTAGSGSKGSDTALYSQVQKSGTPGRWDCGLSRVGNDRVGVKSEGST
uniprot
proteins
function
FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
52170
uniprot
proteins
post_translational_modification
PTM: Constitutively tyrosine-phosphorylated (By similarity). Phosphorylated by TEC. Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway (By similarity). Phosphorylated on tyrosine residues by SRMS (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
DOK family
uniprot
proteins
protein_family
Type A subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins