Rgs2
entrez
84583
canonical
uniprot
Q9JHX0
canonical
ensembl
ENSRNOG00000003687
resolver
ensembl
ENSRNOG00055000807
resolver
ensembl
ENSRNOG00060005468
resolver
ensembl
ENSRNOG00065005731
resolver
ensp
ENSRNOP00000005156
resolver
ensp
ENSRNOP00055001107
resolver
ensp
ENSRNOP00060006854
resolver
ensp
ENSRNOP00065006040
resolver
enst
ENSRNOT00000005156
resolver
enst
ENSRNOT00055001375
resolver
enst
ENSRNOT00060009093
resolver
enst
ENSRNOT00065008565
resolver
genesymbol
Rgs2
resolver
uniprot_entry
RGS2_RAT
resolver
amino_acid_sequence
MQSAMFLAVQHDCVPMDKSAGNGPKVEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKSKQQTFIKPSPEEALLWAEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT
uniprot
proteins
function
FUNCTION: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity). {ECO:0000250|UniProtKB:O08849, ECO:0000250|UniProtKB:P41220}.
uniprot
proteins
mass_dalton
24323
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity. Phosphorylation of Ser-3 protects RGS2 from FBXO44-mediated proteasomal degradation. {ECO:0000250|UniProtKB:P41220}.; PTM: Ubiquitinated by the cullin-RING ligase (CRL) complex composed of CUL4B, DDB1 and FBXO44; ubiquitination leads to RGS2 proteasomal degradation. {ECO:0000250|UniProtKB:P41220}.
uniprot
proteins
pubmed
10692485
uniprot
proteins
pubmed
11409749
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P41220}. Cytoplasm {ECO:0000250|UniProtKB:P41220}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P41220}.
uniprot
proteins