Sag
entrez
20215
canonical
uniprot
P20443
canonical
ensembl
ENSMUSG00000056055
resolver
ensp
ENSMUSP00000076948
resolver
enst
ENSMUST00000077772
resolver
genesymbol
Sag
resolver
uniprot
Q3UPX6
resolver
uniprot
Q91W62
resolver
uniprot_entry
ARRS_MOUSE
resolver
uniprot_entry
Q3UPX6_MOUSE
resolver
uniprot_sec
Q91W62
resolver
amino_acid_sequence
MAACGKTNKSHVIFKKVSRDKSVTIYLGKRDYVDHVSQVEPVDGVVLVDPELVKGKKVYVTLTCAFRYGQEDIDVMGLTFRRDLYFSRVQVYPPVGAMSVLTQLQESLLKKLGDNTYPFLLTFPDYLPCSVMLQPAPQDVGKSCGVDFEVKAFASDITDPEEDKIPKKSSVRLLIRKVQHAPPEMGPQPSAEASWQFFMSDKPLNLSVSLSKEIYFHGEPIPVTVTVTNNTDKVVKKIKVSVEQIANVVLYSSDYYVKPVASEETQEKVQPNSTLTKTLVLVPLLANNRERRGIALDGKIKHEDTNLASSTIIKEGIDRTVMGILVSYHIKVKLTVSGFLGELTSSEVATEVPFRLMHPQPEDPAKESVQDENLVFEEFARQNLKDTGENTEGKKDEDAGQDE
uniprot
proteins
function
FUNCTION: Involved in the regulation of phototransduction, playing a key role in signal termination after rhodopsin (RHO) has been activated by light in rod photoreceptors. Binds to photoactivated and phosphorylated RHO, preventing its interaction with transducin (GNAT1) and terminating transducin-mediated opsin signaling (PubMed:16421323, PubMed:9333241). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (PubMed:16421323). {ECO:0000269|PubMed:16421323, ECO:0000269|PubMed:9333241}.
uniprot
proteins
mass_dalton
44930
uniprot
proteins
mutagenesis
MUTAGEN 86; /note="F->A: Abrogates tetramerization, reduces dimerization, does not affect binding to microtubules and to phosphorylated light-activated rhodopsin; when associated with A-198, or with A-198 and V-349."; /evidence="ECO:0000269|PubMed:21288033"; MUTAGEN 198; /note="F->A: Abrogates tetramerization, reduces dimerization, does not affect binding to microtubules and to phosphorylated light-activated rhodopsin; when associated with A-86, or with A-86 and V-349."; /evidence="ECO:0000269|PubMed:21288033"; MUTAGEN 349; /note="A->V: Abrogates tetramerization, reduces dimerization, does not affect binding to microtubules and to phosphorylated light-activated rhodopsin; when associated with A-86 and A-198."; /evidence="ECO:0000269|PubMed:21288033"; MUTAGEN 374..376; /note="LVF->AAA: Strongly increases affinity for RHO."; /evidence="ECO:0000269|PubMed:26200343
uniprot
proteins
protein_family
Arrestin family
uniprot
proteins
pubmed
12716919
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421323
uniprot
proteins
pubmed
21288033
uniprot
proteins
pubmed
26200343
uniprot
proteins
pubmed
28753425
uniprot
proteins
pubmed
2977355
uniprot
proteins
pubmed
9333241
uniprot
proteins
sequence_length
403
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor inner segment {ECO:0000269|PubMed:12716919}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:12716919, ECO:0000269|PubMed:16421323}. Membrane {ECO:0000269|PubMed:16421323}; Peripheral membrane protein {ECO:0000269|PubMed:16421323}. Note=In dark-adapted retina, it is predominatly localized to the outer nuclear layer and photoreceptor inner segments (PubMed:12716919). Localized to photoreceptor outer segments in light-exposed retina. During light exposure it first accumulates in the proximal region of photoreceptor outer segments, and moves toward the distal tip of the outer segment as light exposure is prolonged (PubMed:12716919). {ECO:0000269|PubMed:12716919}.
uniprot
proteins