Kcnj8
entrez
16523
canonical
uniprot
P97794
canonical
ensembl
ENSMUSG00000030247
resolver
ensp
ENSMUSP00000032374
resolver
ensp
ENSMUSP00000145440
resolver
ensp
ENSMUSP00000183407
resolver
enst
ENSMUST00000032374
resolver
enst
ENSMUST00000203945
resolver
genesymbol
Kcnj8
resolver
uniprot
A0A0J9YMM3
resolver
uniprot
Q3U118
resolver
uniprot_entry
A0A0J9YMM3_MOUSE
resolver
uniprot_entry
KCNJ8_MOUSE
resolver
uniprot_entry
Q3U118_MOUSE
resolver
amino_acid_sequence
MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACNLAHKNIREQGRFLQDIFTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYMEKGTMEKSGLESAVCVTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMKTAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEVVPIHQQDIPVDNPIESNNIFLVAPLIICHVIDKRSPLYDISATDLANQDLEVIVILEGVVETTGITTQARTSYIAEEIQWGHRFVSIVTEEEGVYSVDYSKFGNTVRVAAPRCSARELDEKPSILIQTLQKSELSHQNSLRKRNSMRRNNSMRRNNSIRRNNSSLMVPKVQFMTPEGNQCPSES
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium (By similarity). Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with ABCC9 (PubMed:9130167). {ECO:0000250|UniProtKB:Q15842, ECO:0000269|PubMed:9130167}.
uniprot
proteins
mass_dalton
47980
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ8 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9130167
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 70..94; /note="Helical; Name=M1"; /evidence="ECO:0000250"; TRANSMEM 155..176; /note="Helical; Name=M2"; /evidence="ECO:0000250
uniprot
proteins