G2XKQ0
uniprot
G2XKQ0
canonical
amino_acid_sequence
MSDLEAKPSTEHLGDKIKDEDIKLRVIGQDSSEIHFKVKMTTPLKKLKKSYCQRQGVPVNSLRFLFEGQRIADNHTPEELGMEEEDVIEVYQEQIGGHSTV
uniprot
proteins
function
FUNCTION: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Regulates the life cycle of promyelocytic leukemia nuclear bodies (PML-NBs). PolySUMO1P1/SUMO5 conjugation on 'Lys-160' of PML facilitates recruitment of PML-NB components, which enlarges PML-NB. SUMO1P1/SUMO5 also increases polySUMO2/3 conjugation of PML, resulting in RNF4-mediated disruption of PML-NBs. {ECO:0000269|PubMed:27211601}.
uniprot
proteins
mass_dalton
11526
uniprot
proteins
mutagenesis
MUTAGEN 12; /note="H->D: Does not affect nuclear bodies formation."; /evidence="ECO:0000269|PubMed:27211601"; MUTAGEN 17..21; /note="IKDED->KEGEY: Unable to form nuclear bodies."; /evidence="ECO:0000269|PubMed:27211601"; MUTAGEN 18; /note="K->R: Unable to form nuclear bodies."; /evidence="ECO:0000269|PubMed:27211601"; MUTAGEN 95; /note="I->T: Does not affect nuclear bodies formatiom."; /evidence="ECO:0000269|PubMed:27211601"; MUTAGEN 96..97; /note="GG->AA: Lost the ability to conjugate UBE2I. Unable to form nuclear bodies."; /evidence="ECO:0000269|PubMed:27211601
uniprot
proteins
post_translational_modification
PTM: Cleavage of precursor form is necessary for function. {ECO:0000250|UniProtKB:P63165}.; PTM: Autosumoylated at Lys-18. {ECO:0000269|PubMed:27211601}.
uniprot
proteins
protein_family
SUMO subfamily
uniprot
proteins
protein_family
Ubiquitin family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
27211601
uniprot
proteins
pubmed
30675988
uniprot
proteins
sequence_length
101
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27211601}. Note=Forms prominent non-membrane-bound structures in the nucleus. {ECO:0000269|PubMed:27211601}.
uniprot
proteins