Triobp
entrez
110253
canonical
uniprot
Q99KW3
canonical
ensembl
ENSMUSG00000033088
resolver
ensp
ENSMUSP00000105309
resolver
ensp
ENSMUSP00000105311
resolver
ensp
ENSMUSP00000105312
resolver
ensp
ENSMUSP00000122988
resolver
ensp
ENSMUSP00000155397
resolver
enst
ENSMUST00000109687
resolver
genesymbol
Triobp
resolver
genesymbol_syn
Kiaa1662
resolver
genesymbol_syn
Tara
resolver
uniprot
A0A2U3TZ82
resolver
uniprot
Q2PZW9
resolver
uniprot
Q2Q402
resolver
uniprot
Q2Q403
resolver
uniprot
Q2Q404
resolver
uniprot
Q6ZPK4
resolver
uniprot
Q8C6T3
resolver
uniprot
Q8CG90
resolver
uniprot_entry
A0A2U3TZ82_MOUSE
resolver
uniprot_entry
TARA_MOUSE
resolver
uniprot_sec
Q2PZW9
resolver
uniprot_sec
Q2Q402
resolver
uniprot_sec
Q2Q403
resolver
uniprot_sec
Q2Q404
resolver
uniprot_sec
Q6ZPK4
resolver
uniprot_sec
Q8C6T3
resolver
uniprot_sec
Q8CG90
resolver
amino_acid_sequence
MSMEQDTRALLPTQGTAWATASAPVARLQGPQGDSHQACSQEPHSPSSAEAPYCDLPRCPPALQNPLRTTTCVGQSVHSLGLGLGQEPQRVWSPTTALPAEGPAAAPKNRHQDSEGIPYLEGLARSSCTDDNDNKDEDEDPNSNTSSSQDSNTPHDTSNSSSVDWDTTERPGVVPSRNRLTEMIPRRPQEGLRADSARKATRSPARGDTAGQRKENSGSGGQSAGQHWAKLRSESGYFSLERQRSGQTQASSGTPPSGPRGTTQASSAQRDVFQAAPAQEAPQTSSLPRNTQRDTQRSTPRTSSPSRVSQRDTPRVMSTQRKNTPLSSPLRATPETLKISAPEDGTHVTPSPCVQDSSLNRTSQRDSSRTPCIQWDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCAQRDNPRAASPNRSTQRDSPRTPCAQRDNPRASSPNRTAQRDNPRTPCAQRDNPRTSCTSQNTPRTPSTQADKTTASCSKWEHLRSACTQRDNPRTFSQGCTQKDNPGPPSPRRATQGSNSRNPSPHRTNKDIPWASFPLRPTQSDSPRTSSPSRTKQNQVPWASISLRPTQGDKPQTSAPTRLAHNDPPQQYSPSLATTSSSSHNPGHSSASRTSSPLHAAPRGAPQTSLESSQPPCTVCIGHRDAPRASSPPRYFQYDPFPFFPDPRSSESESPHHEPPYMPPAVCIGHRDAPRATSPPRHTQFDPFPFLPDTSDADNESPQHDPPQFPPPVCIGYRDAPRASSPPRQFPEPSFFQDLPRASTESLVPSTDSMHEPPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSIDSLHGCPLLPPQVCIGHRDAPRASSPPRHPPSDIGLLAPSPPPGSSGSRGSAPPGETRHNLEREEYTMLADLPPPRRLAQRGPEPQAQGSNEGRTRSPGRAEVERLFGQERRKSEAPGAFQTRDEGRSQRPSQAQSQLRRQSSPAPSRQVTKPSAKQAEPTRQSRTGPPHPKSPDKRPEGDRQLQRTSPPARTPARPPERKAQIERHLESGHTGPRQSLGGWQSQERLSGPQSPNRHPEKSWGSQKEGPSLGGWPELEGPSLEGIWRGPPQEHREQWGHSEAWEEPPSNGIQGAPPRGQGRLQELSRPHQPTPSSENSWAGPAECSCALQPEASTAVGWRAEGTSPHQRSAERPPDLDWRDLLGLLRAPEDGAWTRLPRLDWEGLLELLQARLPQKDPARHWHDPAKASGPEQGSSGTEDTLKTEPQTQPEGRAKATLANGHRPGQQSESPAQLPSPACTSTQWPTTKVTSGPETSPLAALEQIDHLESHSPPDLEFQPEEPEASEPSRGEDSRAVQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPALFNPYLLSLGVLRWQRPDLLNFKKGWMSILDEPGEWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDCNKENTLHGYGTQKSSLKIGEQRTGSEVIGRGGPRKADGPRPSLDYVELSPLAPSSPQRMRTLSRSTPERPTKQEDLERDLAQRSEERRKWFESTDGRTPETPSGDGSRRGLGAPLTDDQQSRLSEEIEKKWQELEKLPLRENKRVPLTALLNQAHNDRRGPTSDSHEALEKEVQSLRAQLEAWRLRGEAPQNAPRLQEDSHIPPGYISQEACERSLAEMESSHQQVMEQLQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPESLRKQHQLDMEALKQELQVLSERYSQKCLEIGALTRQAEEREHTLRRCQQEGQELLRHNQELHSHLSEEIDRLRSFIASQGTGNSCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQVIQKDKRFTGKYQDVYVELNHIKTRSEREIEQLKEHLRLAMAALQEKEAVRNSLAE
uniprot
proteins
function
FUNCTION: May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TRIOBP and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. {ECO:0000250|UniProtKB:Q9H2D6}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of rootlets. {ECO:0000269|PubMed:31217345}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of rootlets. {ECO:0000305}.
uniprot
proteins
mass_dalton
223368
uniprot
proteins
post_translational_modification
PTM: [Isoform 1]: Phosphorylation at Thr-445 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation. Phosphorylation at residues Thr-209 and Thr-445 by kinase NEK2A and PLK1 coordinates TERF1 translocation from telomere to spindle pole. {ECO:0000250|UniProtKB:Q9H2D6}.; PTM: Ubiquitinated by HECTD3, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:Q9H2D6}.
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16385457
uniprot
proteins
pubmed
16385458
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
20510926
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
28209736
uniprot
proteins
pubmed
31217345
uniprot
proteins
pubmed
35175278
uniprot
proteins
sequence_length
2014
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:Q9H2D6}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9H2D6}. Midbody {ECO:0000250|UniProtKB:Q9H2D6}. Note=Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-445 and lasts from prophase to anaphase. At telophase, relocalizes to midbody (By similarity). {ECO:0000250|UniProtKB:Q9H2D6}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell projection, stereocilium {ECO:0000269|PubMed:31217345}. Note=Restricted to the lower half of rootlets, immediately below the apical surface of a hair cell within the cuticular plate. {ECO:0000269|PubMed:31217345}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell projection, stereocilium {ECO:0000269|PubMed:31217345}. Note=Detected in the upper half of rootlets embedded in stereocilia cores. {ECO:0000269|PubMed:31217345}.
uniprot
proteins