GNAI2
entrez
2771
canonical
uniprot
P04899
canonical
ensembl
ENSG00000114353
resolver
ensp
ENSP00000266027
resolver
ensp
ENSP00000312999
resolver
ensp
ENSP00000406369
resolver
ensp
ENSP00000406871
resolver
genesymbol
GNAI2
resolver
genesymbol_syn
GNAI2B
resolver
hgnc
HGNC:4385
resolver
uniprot
B3KP24
resolver
uniprot
B3KTZ0
resolver
uniprot
B3KX51
resolver
uniprot
B4DYA0
resolver
uniprot
B4E2X5
resolver
uniprot
Q6B6N3
resolver
uniprot
Q8IZ71
resolver
uniprot_entry
B3KP24_HUMAN
resolver
uniprot_entry
B3KX51_HUMAN
resolver
uniprot_entry
GNAI2_HUMAN
resolver
uniprot_sec
B3KTZ0
resolver
uniprot_sec
B4DYA0
resolver
uniprot_sec
B4E2X5
resolver
uniprot_sec
Q6B6N3
resolver
uniprot_sec
Q8IZ71
resolver
amino_acid_sequence
MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVLPDDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:38505600, PubMed:29925945, PubMed:35637350, PubMed:35365641). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:12359238). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:29925945). Examples of interacting GPCRs include the adenosine A1 receptor/ADORA1, CNR1, and FPR2 (PubMed:29925945, PubMed:35637350, PubMed:35365641). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:12359238). Signaling is mediated via effector proteins, such as adenylate cyclase: inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels. Plays an important role in the activation of the transcription factor NFAT in endothelial cells to promote angiogenesis (PubMed:38505600). The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. Plays an essential role for neutrophil recruitment in the context of acute inflammation suggesting a linked function of both GNAI2 in neutrophils and endothelial cells for polymorphonuclear neutrophils transmigration (By similarity). {ECO:0000250|UniProtKB:P08752, ECO:0000269|PubMed:12359238, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:29925945, ECO:0000269|PubMed:35365641, ECO:0000269|PubMed:35637350, ECO:0000269|PubMed:38505600}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}.
uniprot
proteins
mass_dalton
40451
uniprot
proteins
mutagenesis
MUTAGEN 205; /note="Q->L: Constitutively activated GTPase deficient mutant."; /evidence="ECO:0000269|PubMed:12359238
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Deamidated at Gln-205 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA. {ECO:0000269|PubMed:24141704}.
uniprot
proteins
protein_family
G(i/o/t/z) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
pubmed
12359238
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17550964
uniprot
proteins
pubmed
17635935
uniprot
proteins
pubmed
19211784
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
24141704
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
25807930
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26126266
uniprot
proteins
pubmed
28219978
uniprot
proteins
pubmed
2834384
uniprot
proteins
pubmed
2837412
uniprot
proteins
pubmed
29925945
uniprot
proteins
pubmed
3100330
uniprot
proteins
pubmed
3120178
uniprot
proteins
pubmed
35365641
uniprot
proteins
pubmed
35637350
uniprot
proteins
pubmed
38505600
uniprot
proteins
pubmed
8662698
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17635935}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17635935}. Cell membrane {ECO:0000269|PubMed:17635935}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.
uniprot
proteins