CD47
entrez
961
canonical
uniprot
Q08722
canonical
ensembl
ENSG00000196776
resolver
ensp
ENSP00000347512
resolver
ensp
ENSP00000355361
resolver
ensp
ENSP00000557644
resolver
ensp
ENSP00000557648
resolver
genesymbol
CD47
resolver
genesymbol_syn
MER6
resolver
hgnc
HGNC:1682
resolver
uniprot
A0A0A1TSG4
resolver
uniprot
A8K198
resolver
uniprot
D3DN59
resolver
uniprot
Q53Y71
resolver
uniprot
Q96A60
resolver
uniprot_entry
A0A0A1TSG4_HUMAN
resolver
uniprot_entry
CD47_HUMAN
resolver
uniprot_sec
A8K198
resolver
uniprot_sec
D3DN59
resolver
uniprot_sec
Q53Y71
resolver
uniprot_sec
Q96A60
resolver
amino_acid_sequence
MWPLVAALLLGSACCGSAQLLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTELTREGETIIELKYRVVSWFSPNENILIVIFPIFAILLFWGQFGIKTLKYRSGGMDEKTIALLVAGLVITVIVIVGAILFVPGEYSLKNATGLGLIVTSTGILILLHYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLLISGLSILALAQLLGLVYMKFVASNQKTIQPPRKAVEEPLNAFKESKGMMNDE
uniprot
proteins
function
FUNCTION: Adhesive protein that mediates cell-to-cell interactions (PubMed:11509594, PubMed:15383453). Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (PubMed:19004835, PubMed:7691831, PubMed:8550562). Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed:11509594, PubMed:15383453, PubMed:19004835, PubMed:27742621, PubMed:32679764, PubMed:7691831, PubMed:8550562). Plays a role in modulating pulmonary endothelin EDN1 signaling (PubMed:27742621). Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (PubMed:11509594). Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (PubMed:15383453). Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed:32679764). In response to THBS1, negatively modulates wound healing (By similarity). Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). May play a role in membrane transport and/or integrin dependent signal transduction (PubMed:7691831). May prevent premature elimination of red blood cells (By similarity). {ECO:0000250|UniProtKB:P97829, ECO:0000250|UniProtKB:Q61735, ECO:0000269|PubMed:11509594, ECO:0000269|PubMed:15383453, ECO:0000269|PubMed:19004835, ECO:0000269|PubMed:27742621, ECO:0000269|PubMed:32679764, ECO:0000269|PubMed:7691831, ECO:0000269|PubMed:8550562}.
uniprot
proteins
mass_dalton
35214
uniprot
proteins
pubmed
10549293
uniprot
proteins
pubmed
11454874
uniprot
proteins
pubmed
11509594
uniprot
proteins
pubmed
1394148
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15383453
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15917238
uniprot
proteins
pubmed
18657508
uniprot
proteins
pubmed
19004835
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
22079249
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27742621
uniprot
proteins
pubmed
32679764
uniprot
proteins
pubmed
39121194
uniprot
proteins
pubmed
7691831
uniprot
proteins
pubmed
7998989
uniprot
proteins
pubmed
8550562
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:39121194, ECO:0000269|PubMed:7691831}; Multi-pass membrane protein {ECO:0000269|PubMed:7691831}.
uniprot
proteins
transmembrane_region
TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 208..228; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins