Lepr
entrez
16847
canonical
uniprot
P48356
canonical
ensembl
ENSMUSG00000057722
resolver
ensp
ENSMUSP00000037385
resolver
ensp
ENSMUSP00000099838
resolver
ensp
ENSMUSP00000102534
resolver
ensp
ENSMUSP00000308036
resolver
ensp
ENSMUSP00000308039
resolver
genesymbol
Lepr
resolver
genesymbol_syn
Db
resolver
genesymbol_syn
Obr
resolver
uniprot
O35686
resolver
uniprot
O54986
resolver
uniprot
Q3UNU8
resolver
uniprot
Q3US58
resolver
uniprot
Q61215
resolver
uniprot
Q640Q2
resolver
uniprot
Q64309
resolver
uniprot
Q9QWG3
resolver
uniprot
Q9QWV5
resolver
uniprot_entry
LEPR_MOUSE
resolver
uniprot_entry
Q3UNU8_MOUSE
resolver
uniprot_entry
Q3US58_MOUSE
resolver
uniprot_entry
Q640Q2_MOUSE
resolver
uniprot_sec
O35686
resolver
uniprot_sec
O54986
resolver
uniprot_sec
Q61215
resolver
uniprot_sec
Q64309
resolver
uniprot_sec
Q9QWG3
resolver
uniprot_sec
Q9QWV5
resolver
amino_acid_sequence
MMCQKFYVVLLHWEFLYVIAALNLAYPISPWKFKLFCGPPNTTDDSFLSPAGAPNNASALKGASEAIVEAKFNSSGIYVPELSKTVFHCCFGNEQGQNCSALTDNTEGKTLASVVKASVFRQLGVNWDIECWMKGDLTLFICHMEPLPKNPFKNYDSKVHLLYDLPEVIDDSPLPPLKDSFQTVQCNCSLRGCECHVPVPRAKLNYALLMYLEITSAGVSFQSPLMSLQPMLVVKPDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQYQVKYLENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLDGSGVWSDWSSPQVFTTQDVVYFPPKILTSVGSNASFHCIYKNENQIISSKQIVWWRNLAEKIPEIQYSIVSDRVSKVTFSNLKATRPRGKFTYDAVYCCNEQACHHRYAELYVIDVNINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDSPSIHPTSEPKNCVLQRDGFYECVFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSNVKAEITVNTGLLKVSWEKPVFPENNLQFQIRYGLSGKEIQWKTHEVFDAKSKSASLLVSDLCAVYVVQVRCRRLDGLGYWSNWSSPAYTLVMDVKVPMRGPEFWRKMDGDVTKKERNVTLLWKPLTKNDSLCSVRRYVVKHRTAHNGTWSEDVGNRTNLTFLWTEPAHTVTVLAVNSLGASLVNFNLTFSWPMSKVSAVESLSAYPLSSSCVILSWTLSPDDYSLLYLVIEWKILNEDDGMKWLRIPSNVKKFYIHDNFIPIEKYQFSLYPVFMEGVGKPKIINGFTKDAIDKQQNDAGLYVIVPIIISSCVLLLGTLLISHQRMKKLFWDDVPNPKNCSWAQGLNFQKPETFEHLFTKHAESVIFGPLLLEPEPISEEISVDTAWKNKDEMVPAAMVSLLLTTPDPESSSICISDQCNSANFSGSQSTQVTCEDECQRQPSVKYATLVSNDKLVETDEEQGFIHSPVSNCISSNHSPLRQSFSSSSWETEAQTFFLLSDQQPTMISPQLSFSGLDELLELEGSFPEENHREKSVCYLGVTSVNRRESGVLLTGEAGILCTFPAQCLFSDIRILQERCSHFVENNLSLGTSGENFVPYMPQFQTCSTHSHKIMENKMCDLTV
uniprot
proteins
function
FUNCTION: Receptor for hormone LEP/leptin (Probable) (PubMed:11861497). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS (PubMed:10799542, PubMed:11861497, PubMed:11923481, PubMed:25383904). In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:10660043, PubMed:12594516). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:11923481, PubMed:25383904). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis (PubMed:12594516). Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus (PubMed:25383904). Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (PubMed:9732873). {ECO:0000269|PubMed:10660043, ECO:0000269|PubMed:10799542, ECO:0000269|PubMed:11861497, ECO:0000269|PubMed:11923481, ECO:0000269|PubMed:12594516, ECO:0000269|PubMed:25383904, ECO:0000269|PubMed:9732873, ECO:0000305|PubMed:25232147}.; FUNCTION: [Isoform A]: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis (PubMed:17620316, PubMed:20223942). Does not induce phosphorylation of and activate STAT3 (PubMed:11923481, PubMed:20223942). {ECO:0000269|PubMed:11923481, ECO:0000269|PubMed:17620316, ECO:0000269|PubMed:20223942}.; FUNCTION: [Isoform E]: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis. {ECO:0000269|PubMed:17620316}.
uniprot
proteins
mass_dalton
130789
uniprot
proteins
mutagenesis
MUTAGEN 891; /note="E->A: No effect on STAT3 phosphorylation."; /evidence="ECO:0000269|PubMed:11923481"; MUTAGEN 894; /note="E->A: No effect on STAT3 phosphorylation."; /evidence="ECO:0000269|PubMed:11923481"; MUTAGEN 896..897; /note="LF->AA: Abrogates STAT3 phosphorylation."; /evidence="ECO:0000269|PubMed:11923481"; MUTAGEN 899..900; /note="KH->AA: No effect on STAT3 phosphorylation."; /evidence="ECO:0000269|PubMed:11923481"; MUTAGEN 902; /note="E->A: No effect on STAT3 phosphorylation."; /evidence="ECO:0000269|PubMed:11923481"; MUTAGEN 908; /note="P->A: No effect on STAT3 phosphorylation."; /evidence="ECO:0000269|PubMed:11923481"; MUTAGEN 985; /note="Y->L: No change in EPO-induced JAK2 activation and EPO-induced tyrosine phosphorylation. No phosphorylation; when associated with S-1138. No phosphorylation; when associated with both S-1138 and F-1077. No change in STAT3 activation. No PTPN11 binding. No SOCS3 binding nor inhibition of signaling. Greatly reduced ERK/FOS activation. Mutants are hyperphagic, obese and hyperglycaemic, females show a defect in lactation."; /evidence="ECO:0000269|PubMed:10799542, ECO:0000269|PubMed:11018044, ECO:0000269|PubMed:12594516"; MUTAGEN 1077; /note="Y->F: No effect on EPO-induced tyrosine phosphorylation."; /evidence="ECO:0000269|PubMed:10799542"; MUTAGEN 1138; /note="Y->S: No change in EPO-induced JAK2 activation and EPO-induced tyrosine phosphorylation. No phosphorylation; when associated with L-985. No phosphorylation; when associated with L-985 and F-1077. No STAT3 activation. No change in SOCS3 binding nor signaling inhibition. No effect on ERK/FOS activation."; /evidence="ECO:0000269|PubMed:10799542, ECO:0000269|PubMed:11018044
uniprot
proteins
post_translational_modification
PTM: On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-985 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1138 is required for STAT3 binding/activation. Phosphorylation of Tyr-1077 has a more accessory role. {ECO:0000269|PubMed:10799542, ECO:0000269|PubMed:11108838}.
uniprot
proteins
protein_family
Type 2 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
10660043
uniprot
proteins
pubmed
10799542
uniprot
proteins
pubmed
11018044
uniprot
proteins
pubmed
11108838
uniprot
proteins
pubmed
11861497
uniprot
proteins
pubmed
11923481
uniprot
proteins
pubmed
12196522
uniprot
proteins
pubmed
12594516
uniprot
proteins
pubmed
17620316
uniprot
proteins
pubmed
20223942
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25232147
uniprot
proteins
pubmed
25383904
uniprot
proteins
pubmed
8548812
uniprot
proteins
pubmed
8608603
uniprot
proteins
pubmed
8616721
uniprot
proteins
pubmed
8628397
uniprot
proteins
pubmed
8692797
uniprot
proteins
pubmed
9322935
uniprot
proteins
pubmed
9344648
uniprot
proteins
pubmed
9732873
uniprot
proteins
pubmed
9845674
uniprot
proteins
sequence_length
1162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P48357}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P48357}. Basolateral cell membrane {ECO:0000250|UniProtKB:P48357}.; SUBCELLULAR LOCATION: [Isoform E]: Secreted {ECO:0000305|PubMed:17620316}.
uniprot
proteins
transmembrane_region
TRANSMEM 840..860; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins