Adi1
entrez
104923
canonical
uniprot
Q99JT9
canonical
ensembl
ENSMUSG00000020629
resolver
ensp
ENSMUSP00000020957
resolver
enst
ENSMUST00000020957
resolver
genesymbol
Adi1
resolver
genesymbol_syn
Mtcbp1
resolver
uniprot_entry
MTND_MOUSE
resolver
amino_acid_sequence
MVQAWYMDESTADPRKPHRAQPDRPVSLEQLRTLGVLYWKLDADKYENDPELEKIRKMRNYSWMDIITICKDTLPNYEEKIKMFFEEHLHLDEEIRYILEGSGYFDVRDKEDKWIRISMEKGDMITLPAGIYHRFTLDEKNYVKAMRLFVGEPVWTPYNRPADHFDARVQYMSFLEGTA
uniprot
proteins
ec_number
1.13.11.53
uniprot
proteins
ec_number
1.13.11.54
uniprot
proteins
function
FUNCTION: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (PubMed:26858196). Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway (PubMed:26858196). Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (PubMed:26858196). Also down-regulates cell migration mediated by MMP14 (By similarity). {ECO:0000255|HAMAP-Rule:MF_03154, ECO:0000269|PubMed:26858196}.
uniprot
proteins
mass_dalton
21524
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. {ECO:0000255|HAMAP-Rule:MF_03154}.
uniprot
proteins
protein_family
Acireductone dioxygenase (ARD) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16783794
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26858196
uniprot
proteins
sequence_length
179
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03154}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03154}. Cell membrane {ECO:0000255|HAMAP-Rule:MF_03154}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03154}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03154}. Note=Localizes to the plasma membrane when complexed to MMP14. {ECO:0000255|HAMAP-Rule:MF_03154}.
uniprot
proteins