Rbm46
entrez
633285
canonical
uniprot
P86049
canonical
ensembl
ENSMUSG00000033882
resolver
ensp
ENSMUSP00000045511
resolver
ensp
ENSMUSP00000138429
resolver
enst
ENSMUST00000048647
resolver
enst
ENSMUST00000182818
resolver
genesymbol
Rbm46
resolver
uniprot
S4R1Y9
resolver
uniprot_entry
RBM46_MOUSE
resolver
uniprot_entry
S4R1Y9_MOUSE
resolver
amino_acid_sequence
MNEENTDGTNGCSKVRTGTQNEAALLALMEKTGYNMVQENGQRKFGGPPPGWEGPPPPRGCEVFVGKIPRDMYEDELVPVFERAGKIYEFRLMMEFSGENRGYAFVMYTTKEEAQLAIRILNNYEIRPGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDEMKKVTEGVVDVIVYPSATDKTKNRGFAFVEYESHRAAAMARRKLIPGTFQLWGHTIQVDWADPEKEVDEETMQRVKVLYVRNLMISTTEETIKAEFSKFKPGAVERVKKLRDYAFVHFFHREDAVAAMSVMNGKCIDGASIEVTLAKPVNKENTWRQHLNGQISPNSENLLVYANKEESHSKSLGKPPTLPTRLNGQHSPSPPEIERCTYPFFPGTKLTPISMYSLKSNHFNSAVMHLDYYCNKNNWAPPEYYLYSTTSQDGKVLLVYKIVIPAIANGSQSYFMPDKLCTTLEDAKELAAQFTLLHLDFNFRRSSINSLSPVSTTLSSGTPSMLPYTSRPSSYPSYPLSPTISLANGSHVGQRLYISNQASFF
uniprot
proteins
function
FUNCTION: Essential for male and female fertility, playing a crucial role in regulating germ cell development by ensuring the proper progression of meiosis prophase I (PubMed:36001654, PubMed:36129965, PubMed:36726756). Regulates mitotic-to-meiotic transition in spermatogenesis by forming a complex with MEIOC and YTHDC2 which recognizes and down-regulates mitotic transcripts for a successful meiotic entry (PubMed:36129965). Required for normal synaptonemal complex formation during meiosis, binding meiotic cohesin subunit mRNAs containing GCCUAU/GUUCGA motifs in their 3'UTRs regions and positively regulating their translation (PubMed:36726756). Required for spermatogonial differentiation in both developing and adult testis (PubMed:36129965). {ECO:0000269|PubMed:36001654, ECO:0000269|PubMed:36129965, ECO:0000269|PubMed:36726756}.
uniprot
proteins
mass_dalton
60077
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36001654
uniprot
proteins
pubmed
36129965
uniprot
proteins
pubmed
36726756
uniprot
proteins
sequence_length
533
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36001654, ECO:0000269|PubMed:36129965, ECO:0000269|PubMed:36726756}.
uniprot
proteins