Psmc5
entrez
19184
canonical
uniprot
P62196
canonical
ensembl
ENSMUSG00000020708
resolver
ensp
ENSMUSP00000021049
resolver
enst
ENSMUST00000021049
resolver
genesymbol
Psmc5
resolver
genesymbol_syn
Sug1
resolver
uniprot
O35051
resolver
uniprot
P47210
resolver
uniprot
P52915
resolver
uniprot
P52916
resolver
uniprot
Q3UL51
resolver
uniprot
Q9CWN5
resolver
uniprot_entry
PRS8_MOUSE
resolver
uniprot_sec
O35051
resolver
uniprot_sec
P47210
resolver
uniprot_sec
P52915
resolver
uniprot_sec
P52916
resolver
uniprot_sec
Q3UL51
resolver
uniprot_sec
Q9CWN5
resolver
amino_acid_sequence
MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000250|UniProtKB:P62195}.
uniprot
proteins
mass_dalton
45626
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16857966
uniprot
proteins
pubmed
17349974
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8598193
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62195}. Nucleus {ECO:0000250|UniProtKB:P62195}.
uniprot
proteins