Cfdp1
entrez
292027
canonical
uniprot
Q75UQ2
canonical
ensembl
ENSRNOG00000019326
resolver
ensembl
ENSRNOG00055018546
resolver
ensembl
ENSRNOG00060012607
resolver
ensembl
ENSRNOG00065011175
resolver
ensp
ENSRNOP00000073816
resolver
ensp
ENSRNOP00000083789
resolver
ensp
ENSRNOP00055025498
resolver
ensp
ENSRNOP00060016899
resolver
ensp
ENSRNOP00065013791
resolver
enst
ENSRNOT00000089873
resolver
enst
ENSRNOT00000112483
resolver
enst
ENSRNOT00055031564
resolver
enst
ENSRNOT00060021400
resolver
enst
ENSRNOT00065018101
resolver
genesymbol
Cfdp1
resolver
genesymbol_syn
Bcnt
resolver
uniprot
A0A0G2K6H5
resolver
uniprot_entry
A0A0G2K6H5_RAT
resolver
uniprot_entry
CFDP1_RAT
resolver
amino_acid_sequence
MEEFDSEDFSTSDEDEDYVPSGGEYSEDDVNELVKEDEVDGEEQAEKTKGKRRKAQSIPARKRKQSGLLLDEEEDGEEDSGGSSREEDEEEQEGGLGSETSRKKKEDELWASFLNDVGTKSKAASSSQVKVAEETEETSSSKPLVKADELEKPKESEKVKITKVFDFAGEEVRVTKEVDATSKEAKSFLKQTEKEKPQALVTSAATPPPAGSGIKRTSGMSSLLGKIGAKKQKMSTLEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLERVDHRQFEIERDLRLSKMKP
uniprot
proteins
function
FUNCTION: Required for the structural stability of pericentromeric heterochromatin. Regulates heterochromatin state by stabilizing CBX5/HP1alpha and H3K9me3 at major satellites and CENPA at minor satellites and is required for incorporation of histone H2AZ1/H2AZ into chromatin. Maintenance of chromatin structure promotes binding of guanine-nucleotide releasing factor RCC1 to minor and major satellite repeats. Chromatin-bound RCC1 maintains high levels of GTP-bound RAN near the centromeric heterochromatin, facilitating RAN-mediated microtubule nucleation during mitosis. Plays a role in craniofacial development. Required to maintain normal cell function in embryonic development. {ECO:0000250|UniProtKB:O88271}.
uniprot
proteins
mass_dalton
32969
uniprot
proteins
protein_family
SWC5/CFDP1/CFDP2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9UEE9}. Nucleus {ECO:0000250|UniProtKB:O88271}. Chromosome {ECO:0000250|UniProtKB:O88271}. Note=Colocalizes with heterochromatin at major and minor satellites. {ECO:0000250|UniProtKB:O88271}.
uniprot
proteins