Tead3
entrez
21678
canonical
uniprot
P70210
canonical
ensembl
ENSMUSG00000002249
resolver
ensp
ENSMUSP00000110447
resolver
ensp
ENSMUSP00000115443
resolver
ensp
ENSMUSP00000118582
resolver
enst
ENSMUST00000114799
resolver
enst
ENSMUST00000154873
resolver
enst
ENSMUST00000156862
resolver
genesymbol
Tead3
resolver
genesymbol_syn
Tcf13r2
resolver
genesymbol_syn
Tef5
resolver
uniprot
F8VPU0
resolver
uniprot
O08516
resolver
uniprot
O70623
resolver
uniprot
P70209
resolver
uniprot_entry
F8VPU0_MOUSE
resolver
uniprot_entry
TEAD3_MOUSE
resolver
uniprot_sec
O08516
resolver
uniprot_sec
O70623
resolver
uniprot_sec
P70209
resolver
amino_acid_sequence
MASNSWTANSSPGEAREDGSEGLDKGLDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSSSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPALNSYESLAPLPPAAASATASAPAWQDRTIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEGPGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD
uniprot
proteins
function
FUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
48938
uniprot
proteins
pubmed
8920920
uniprot
proteins
pubmed
9502435
uniprot
proteins
pubmed
9671946
uniprot
proteins
sequence_length
439
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins