Abhd8
entrez
64296
canonical
uniprot
Q8R0P8
canonical
ensembl
ENSMUSG00000007950
resolver
ensp
ENSMUSP00000008094
resolver
enst
ENSMUST00000008094
resolver
genesymbol
Abhd8
resolver
uniprot
Q9DC79
resolver
uniprot
Q9JMF5
resolver
uniprot_entry
ABHD8_MOUSE
resolver
uniprot_sec
Q9DC79
resolver
uniprot_sec
Q9JMF5
resolver
amino_acid_sequence
MTSEHTMLTGVTDGFFCCLLGTPPNAVRPLESVESSDGYTFVEVKPGRVLRVKHAGPAPIPTPPPPPPEDDPGVKTGLVRCQRRITVYRNGRLVVENLGRAPRADLQGRSGSGDPPAALEVELAEPAGGDTRANPGSGRRRRPRRPKRTIHIDCEQRITSCKGAQADVVLFFIHGVGGSLAIWKEQLDFFVRLGYEVVAPDLAGHGASSAPQVAAAYTFYALAEDMRAIFTRYAKKRNVLIGHSYGVSFCTFLAHEYPDLVHKVIMINGGGPTALEPSLCSIFNMPTCVLHCLSPCLAWSFLKAGFARQGAKEKQLLKEGNAFNVSSFVLRAMMSGQYWPEGDEVYHAELTVPVLLVHGMHDKFVPVEEDQRMAEILLLAFLKLIEEGSHMVMLECPETVNTLLHEFLLWEPEPEAEPKLEPKPKPQLLQPEPAPGEEK
uniprot
proteins
ec_number
3.-.-.-
uniprot
proteins
function
FUNCTION: Negatively regulates NLRP3-driven inflammation (PubMed:39225180). Promotes NLRP3 degradation through the chaperone-mediated autophagy (CMA) pathway, hence attenuating inflammasome activation and IL1B secretion. Acts by recruiting palmitoyltransferase ZDHHC12 to NLRP3, facilitating NLRP3 palmitoylation and subsequent degradation (By similarity). {ECO:0000250|UniProtKB:Q96I13, ECO:0000269|PubMed:39225180}.
uniprot
proteins
mass_dalton
48229
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
10679242
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
39225180
uniprot
proteins
sequence_length
439
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96I13}.
uniprot
proteins