Stom
entrez
13830
canonical
uniprot
P54116
canonical
ensembl
ENSMUSG00000026880
resolver
ensp
ENSMUSP00000028241
resolver
enst
ENSMUST00000028241
resolver
genesymbol
Stom
resolver
genesymbol_syn
Epb7.2
resolver
genesymbol_syn
Epb72
resolver
uniprot
O88988
resolver
uniprot
Q3UP81
resolver
uniprot
Q60744
resolver
uniprot
Q62455
resolver
uniprot_entry
STOM_MOUSE
resolver
uniprot_sec
O88988
resolver
uniprot_sec
Q3UP81
resolver
uniprot_sec
Q60744
resolver
uniprot_sec
Q62455
resolver
amino_acid_sequence
MSDKRQSSHVQSQRIPESFRENSKTELGACGWILVAASFFFVIITFPISIWICIKIVKEYERVIIFRLGRILQGGAKGPGLFFILPCTDSLIKVDMRTISFDIPPQEVLTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNALGTKNLSQILSDREEIAHHMQSTLDDATDDWGIKVERVEIKDVKLPVQLQRAMAAEAEAAREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPVDMLQGIMGSNH
uniprot
proteins
function
FUNCTION: Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity. {ECO:0000269|PubMed:15471860, ECO:0000269|PubMed:22850675}.
uniprot
proteins
mass_dalton
31375
uniprot
proteins
mutagenesis
MUTAGEN 97; /note="R->D: Does not abolish interaction with ASIC3, but abolishes regulation of ASIC3 channel activity; when associated with D-109 and D-145."; /evidence="ECO:0000269|PubMed:22850675"; MUTAGEN 109; /note="L->D: Does not abolish interaction with ASIC3, but abolishes regulation of ASIC3 channel activity; when associated with D-97 and D-145."; /evidence="ECO:0000269|PubMed:22850675"; MUTAGEN 145; /note="L->D: Does not abolish interaction with ASIC3, but abolishes regulation of ASIC3 channel activity; when associated with D-97 and D-109."; /evidence="ECO:0000269|PubMed:22850675"; MUTAGEN 182; /note="T->W: Does not abolish interaction with ASIC3, but abolishes regulation of ASIC2 and ASIC3 channel activity."; /evidence="ECO:0000269|PubMed:22850675"; MUTAGEN 197; /note="V->P: Abolishes homodimerization and oligomerization. Abolishes regulation of ASIC2 and ASIC3 channel activity."; /evidence="ECO:0000269|PubMed:22850675
uniprot
proteins
protein_family
Band 7/mec-2 family
uniprot
proteins
pubmed
10383825
uniprot
proteins
pubmed
15471860
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22850675
uniprot
proteins
pubmed
7540886
uniprot
proteins
pubmed
8786142
uniprot
proteins
pubmed
8921901
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P27105}; Peripheral membrane protein {ECO:0000250|UniProtKB:P27105}; Cytoplasmic side {ECO:0000250|UniProtKB:P27105}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P27105}. Cell membrane {ECO:0000250|UniProtKB:P27105}; Lipid-anchor {ECO:0000250|UniProtKB:P27105}; Cytoplasmic side {ECO:0000250|UniProtKB:P27105}. Membrane raft {ECO:0000250|UniProtKB:P27105}. Melanosome {ECO:0000250|UniProtKB:P27105}. Cytoplasmic vesicle {ECO:0000269|PubMed:10383825}. Note=Localizes to juxtanuclear structure probably derived from the Golgi apparatus. Colocalizes with cortical actin microfilaments at small plasma membrane protrusions. Associates with alpha-granular lipid rafts. Translocates from the alpha-granular lipid rafts to the cell membrane on thrombin activation and selectively enriched in released microvesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250|UniProtKB:P27105}.
uniprot
proteins