Asic3
entrez
171209
canonical
uniprot
Q6X1Y6
canonical
ensembl
ENSMUSG00000038276
resolver
ensp
ENSMUSP00000039914
resolver
ensp
ENSMUSP00000143083
resolver
genesymbol
Asic3
resolver
genesymbol_syn
Accn3
resolver
genesymbol_syn
Drasic
resolver
uniprot
Q7TQH4
resolver
uniprot_entry
ASIC3_MOUSE
resolver
uniprot_sec
Q7TQH4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the diuretic drug amiloride (By similarity). Potentiated by FMRFamide-related neuropeptides, which are induced during inflammation and modulate pain responses (PubMed:10798398). {ECO:0000250|UniProtKB:Q9UHC3, ECO:0000269|PubMed:10798398}.
uniprot
proteins
amino_acid_sequence
MKPPSGLEEAQRRQASDIRVFANSCTMHGLGHIFGPGGLTLRRGLWATAVLLSLAAFLYQVAERVRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRRSRLTPNDLHWAGTALLGLDPAEHAAYLRALGQPPAPPGFMPSPTFDMAQLYARAGHSLEDMLLDCRYRGQPCGPENFTVIFTRMGQCYTFNSGAQGAELLTTPKGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHGQEEPPAIDQLGFGAAPGHQTFVSCQQQQLSFLPPPWGDCNTASVDPDFDPEPSDPLGSPSSSPPYSLIGCRLACESRYVARKCGCRMMHMPGNSPVCSPQQYKDCASPALDAMLRKDTCVCPNPCATTRYAKELSMVRIPSRASARYLARKYNRSETYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFIGASLLTILEILDYLCEVFQDRVLGYFWNRRSSQRRSGNTLLQEELNGHRTHVPHLSLGPRPPTAPSAVTKTLAASHRTCYLVTRL
uniprot
proteins
function
FUNCTION: Forms voltage-independent, pH-gated heterotrimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system (PubMed:11754838, PubMed:14659506). Upon extracellular acidification, these channels generate a biphasic current with a fast inactivating and a slow sustained phase (PubMed:11754838). ASIC3 is more sensitive to protons and gates between closed, open, and desensitized states faster than other ASICs (PubMed:11754838). Displays high selectivity for sodium ions but can also permit the permeation of other cations (By similarity). As a neuronal acid sensor, probably contributes to mechanoreception, acid nociception, and heat nociception (PubMed:11754838, PubMed:12060708). By forming heterotrimeric channels with ASIC2, generates a biphasic current with a fast inactivating and a slow sustained phase, which in sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissues (By similarity). {ECO:0000250|UniProtKB:O35240, ECO:0000269|PubMed:11754838, ECO:0000269|PubMed:12060708, ECO:0000269|PubMed:14659506}.
uniprot
proteins
mass_dalton
58704
uniprot
proteins
protein_family
ASIC3 subfamily
uniprot
proteins
protein_family
Amiloride-sensitive sodium channel (TC 1.A.6) family
uniprot
proteins
pubmed
10798398
uniprot
proteins
pubmed
11754838
uniprot
proteins
pubmed
12060708
uniprot
proteins
pubmed
14659506
uniprot
proteins
pubmed
15051137
uniprot
proteins
pubmed
15317815
uniprot
proteins
pubmed
15471860
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22850675
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9UHC3}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:15051137}. Note=Preferentially expressed at the plasma membrane of the soma and cellular processes of neurons (By similarity). In part cytoplasmic in cochlea cells (PubMed:15051137). Localized in specialized sensory nerve endings (PubMed:11754838). {ECO:0000250|UniProtKB:O35240, ECO:0000269|PubMed:11754838, ECO:0000269|PubMed:15051137}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..62; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 441..460; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins