FBXW5
entrez
54461
canonical
uniprot
Q969U6
canonical
ensembl
ENSG00000159069
resolver
ensp
ENSP00000313034
resolver
ensp
ENSP00000528319
resolver
ensp
ENSP00000528325
resolver
ensp
ENSP00000640290
resolver
ensp
ENSP00000713453
resolver
genesymbol
FBXW5
resolver
genesymbol_syn
FBW5
resolver
hgnc
HGNC:13613
resolver
uniprot
B2RDZ6
resolver
uniprot
Q59ET5
resolver
uniprot
Q5SPZ8
resolver
uniprot
Q5SPZ9
resolver
uniprot
Q5SQ00
resolver
uniprot
Q5SQ02
resolver
uniprot
Q5SQ03
resolver
uniprot
Q5SQ04
resolver
uniprot
Q8WY79
resolver
uniprot
Q96GJ6
resolver
uniprot
Q9BSU8
resolver
uniprot
Q9H6A8
resolver
uniprot
Q9HBQ6
resolver
uniprot
Q9NSZ3
resolver
uniprot_entry
FBXW5_HUMAN
resolver
uniprot_sec
B2RDZ6
resolver
uniprot_sec
Q59ET5
resolver
uniprot_sec
Q5SPZ8
resolver
uniprot_sec
Q5SPZ9
resolver
uniprot_sec
Q5SQ00
resolver
uniprot_sec
Q5SQ02
resolver
uniprot_sec
Q5SQ03
resolver
uniprot_sec
Q5SQ04
resolver
uniprot_sec
Q8WY79
resolver
uniprot_sec
Q96GJ6
resolver
uniprot_sec
Q9BSU8
resolver
uniprot_sec
Q9H6A8
resolver
uniprot_sec
Q9HBQ6
resolver
uniprot_sec
Q9NSZ3
resolver
amino_acid_sequence
MDEGGTPLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQFYRYYQVARDVPRHPAAMSWYEEFQRLYDTVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVKIWSNDLTISLLHSADMRPYNWSYTQFSQFNKDDSLLLASGVFLGPHNSSSGEIAVISLDSFALLSRVRNKPYDVFGCWLTETSLISGNLHRIGDITSCSVLWLNNAFQDVESENVNVVKRLFKIQNLNASTVRTVMVADCSRFDSPDLLLEAGDPATSPCRIFDLGSDNEEVVAGPAPAHAKEGLRHFLDRVLEGRAQPQLSERMLETKVAELLAQGHTKPPERSATGAKSKYLIFTTGCLTYSPHQIGIKQILPHQMTTAGPVLGEGRGSDAFFDALDHVIDIHGHIIGMGLSPDNRYLYVNSRAWPNGAVVADPMQPPPIAEEIDLLVFDLKTMREVRRALRAHRAYTPNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLARLRHEDVVNSVVFSPQEQELLLTASDDATIKAWRSPRTMRVLQAPRPRPRTFFSWLASQRR
uniprot
proteins
function
FUNCTION: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. {ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:19232515, ECO:0000269|PubMed:21725316}.
uniprot
proteins
mass_dalton
63922
uniprot
proteins
mutagenesis
MUTAGEN 151; /note="S->A: Impairs phosphorylation by PLK4 and enhances ubiquitination of SASS6."; /evidence="ECO:0000269|PubMed:21725316
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-151 by PLK4 during the G1/S transition, leading to inhibit its ability to ubiquitinate SASS6. {ECO:0000269|PubMed:21725316}.; PTM: Ubiquitinated and degraded by the APC/C complex during mitosis and G1 phase. {ECO:0000269|PubMed:21725316}.
uniprot
proteins
protein_family
FBXW5 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18381890
uniprot
proteins
pubmed
19232515
uniprot
proteins
pubmed
21725316
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
566
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21725316}.
uniprot
proteins