Cblc
entrez
80794
canonical
uniprot
Q80XL1
canonical
ensembl
ENSMUSG00000040525
resolver
ensp
ENSMUSP00000039955
resolver
ensp
ENSMUSP00000104088
resolver
enst
ENSMUST00000108449
resolver
genesymbol
Cblc
resolver
genesymbol_syn
Cbl3
resolver
uniprot
G3X9U0
resolver
uniprot
Q99PB6
resolver
uniprot
Q9D6L2
resolver
uniprot
Q9D7A9
resolver
uniprot_entry
CBLC_MOUSE
resolver
uniprot_entry
G3X9U0_MOUSE
resolver
uniprot_sec
Q99PB6
resolver
uniprot_sec
Q9D6L2
resolver
uniprot_sec
Q9D7A9
resolver
activity_regulation
ACTIVITY REGULATION: Phosphorylation at Tyr-340 is necessary and sufficient for the activation of E3 activity. {ECO:0000250|UniProtKB:Q9ULV8}.
uniprot
proteins
amino_acid_sequence
MAAAAAPRGWQRGEPRALSRAVKLLQRLEEQCRDPRMVTGPPSLRDLLPRTAQLLGEVAKARREAREDPEGPGGADDFLAIYLANLEVKGRQVAELLPPRGKKDVNQDVFREGSRFRRQLAKLALIFSHMHAELSALFPAGKYCGHLYQLTKGSAHIFWRQNCGVRCVLPWAEFQSLLCACHPVEPGPTMQALRSTLDLTCNGHVSVFEFDVFTRLFQPWPTLLRNWQLLAVNHPGYMAFLTYDEVQTRLQAYRDKPGSYIFRPSCTRLGQWAIGYVSSDGSILQTIPLNKPLLQVLLKGQKDGIFLFPDGKKHNPDLTELCRVEPYQRIQVSEEQLLLYQAMNSTFQLCKICAERDKDVRIEPCGHLLCSCCLAAWQDSDSQTCPFCRCEIKGREAVSICQAQERPTEVRTAADGSRDNCHQEAAEQKLGPVIPSAPSLLPEDQFPQGPQDKGWLTLAPLALPRLRPPLPLPKMASVLWEVTSRPRAREEATESS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-424', has the highest ubiquitin ligase activity among CBL family proteins. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. {ECO:0000250|UniProtKB:Q9ULV8}.
uniprot
proteins
mass_dalton
55715
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines by EGFR. {ECO:0000250}.; PTM: Phosphorylated on multiple tyrosine residues by SRC. Isoform 1, but not isoform 2, is phosphorylated on tyrosines by EGFR. {ECO:0000250|UniProtKB:Q9ULV8}.; PTM: Autoubiquitinated, when phosphorylated at Tyr-340. {ECO:0000250|UniProtKB:Q9ULV8}.
uniprot
proteins
pubmed
11162497
uniprot
proteins
pubmed
14560016
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
496
uniprot
proteins