ATP2C2
entrez
9914
canonical
uniprot
O75185
canonical
ensembl
ENSG00000064270
resolver
ensp
ENSP00000262429
resolver
ensp
ENSP00000397925
resolver
genesymbol
ATP2C2
resolver
genesymbol_syn
KIAA0703
resolver
genesymbol_syn
SPCA2
resolver
hgnc
HGNC:29103
resolver
uniprot
B3KR57
resolver
uniprot
B4DU76
resolver
uniprot
E7ES94
resolver
uniprot
Q5HYC3
resolver
uniprot
Q5S053
resolver
uniprot
Q68CQ2
resolver
uniprot_entry
AT2C2_HUMAN
resolver
uniprot_entry
B3KR57_HUMAN
resolver
uniprot_sec
B4DU76
resolver
uniprot_sec
E7ES94
resolver
uniprot_sec
Q5HYC3
resolver
uniprot_sec
Q5S053
resolver
uniprot_sec
Q68CQ2
resolver
amino_acid_sequence
MVEGRVSEFLKKLGFSGGGRQYQALEKDEEEALIDEQSELKAIEKEKKVTALPPKEACKCQKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSALVSVLTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELTKLVPPECNCLREGKLQHLLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKMDLSDIKNSYIRKKEIPFSSEQKWMAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQEEKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKLQAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGTLFIFWKEMPEDRASTPRTTTMTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGALDLLFLTGLASSVFILSELLKLCEKYCCSPKRVQMHPEDV
uniprot
proteins
ec_number
7.2.2.10
uniprot
proteins
function
FUNCTION: ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:15677451, PubMed:15831496, PubMed:16332677, PubMed:30923126). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:15831496, PubMed:16332677). Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May facilitate transepithelial transport of large quantities of Ca(2+) for milk secretion via activation of Ca(2+) influx channels at the plasma membrane and active Ca(2+) transport at the Golgi apparatus (PubMed:20887894, PubMed:23840669). {ECO:0000269|PubMed:15677451, ECO:0000269|PubMed:15831496, ECO:0000269|PubMed:16332677, ECO:0000269|PubMed:20887894, ECO:0000269|PubMed:23840669, ECO:0000269|PubMed:30923126}.
uniprot
proteins
mass_dalton
103169
uniprot
proteins
mutagenesis
MUTAGEN 379; /note="D->N: Loss of calcium-dependent ATPase activity. Has no effect on trafficking to the plasma membrane."; /evidence="ECO:0000269|PubMed:20887894"; MUTAGEN 772; /note="D->A: Loss of calcium-dependent ATPase activity."; /evidence="ECO:0000269|PubMed:20887894
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIA subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
15677451
uniprot
proteins
pubmed
15831496
uniprot
proteins
pubmed
16332677
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20887894
uniprot
proteins
pubmed
23840669
uniprot
proteins
pubmed
30923126
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
946
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15831496}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:20887894}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:A7L9Z8}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 107..127; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 130..150; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 294..314; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 332..352; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 751..771; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 805..825; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 838..855; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 875..895; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 906..926; /note="Helical; Name=10"; /evidence="ECO:0000255
uniprot
proteins