Chn2
entrez
84031
canonical
uniprot
Q03070
canonical
ensembl
ENSRNOG00000009411
resolver
ensp
ENSRNOP00000012655
resolver
ensp
ENSRNOP00000082836
resolver
enst
ENSRNOT00000012655
resolver
enst
ENSRNOT00000112440
resolver
genesymbol
Chn2
resolver
genesymbol_syn
Arhgap3
resolver
genesymbol_syn
Bch
resolver
uniprot
A0A8I5ZYQ0
resolver
uniprot
G3V773
resolver
uniprot_entry
A0A8I5ZYQ0_RAT
resolver
uniprot_entry
CHIO_RAT
resolver
uniprot_entry
G3V773_RAT
resolver
activity_regulation
ACTIVITY REGULATION: In the inactive state, the N terminus protrudes into the active site of the Rho-GAP domain, sterically blocking Rac binding. Phospholipid binding to the Phorbol-ester/DAG-type zinc-finger/C1 domain triggers the cooperative dissociation of these interactions, allowing the N-terminus to move out of the active site and thereby activating the enzyme (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MLCTSPVNCLDSVCCTSINISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANIYPDINIITGALKLYFRDLPIPIITYDTYTKFIEAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNLMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF
uniprot
proteins
function
FUNCTION: GTPase-activating protein for p21-rac.
uniprot
proteins
mass_dalton
33837
uniprot
proteins
pubmed
8440677
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins