Enkd1
entrez
102124
canonical
uniprot
Q7TSV9
canonical
ensembl
ENSMUSG00000013155
resolver
ensp
ENSMUSP00000013299
resolver
ensp
ENSMUSP00000170687
resolver
ensp
ENSMUSP00000170688
resolver
ensp
ENSMUSP00000170696
resolver
ensp
ENSMUSP00000170697
resolver
enst
ENSMUST00000013299
resolver
genesymbol
Enkd1
resolver
uniprot_entry
ENKD1_MOUSE
resolver
amino_acid_sequence
MCEGPSRISGPIPPDPTLCPDYYRRPASAQGRLEGNALKLDLLTSGRDLDSSPPRGPRIRPEAREILERGQRGVGDVLLQLGCISLGSGVSPKRKNPKDHEKENLRRIKEIQRRFQDQERSREQGQPKPLKALWRSPKYDNVESRVKARMKELGPTSVTEPAHFLRAHSRCGPGLPPSRASSPQLALPGPQAKGPGLGVDFISRNALAAKRAPRRHSRSLQVLAQVQEQQRQAQERYNATQKGHVPHYLLERRDLWRKEAEARQRSQPDPSMPPGHTLMPENQRLETLNNLLQSQSQLLRELVLLPAGADSLRAQGHRAELDRKLVQIEEAIKIFSRPKVFVKMDT
uniprot
proteins
function
FUNCTION: Microtubule-binding protein which regulates microtubule organization and stability (By similarity). Promotes the stability of astral microtubules and facilitates the proper orientation of the mitotic spindle (By similarity). This allows the oriented division of basal keratinocytes and contributes to epidermal stratification (PubMed:35197565). Required for the assembly of both primary and motile cilia (PubMed:35072334, PubMed:35301795). Destabilizes the interaction between CCP110 and CEP97 by competing with CEP97 for binding to CCP110 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis (PubMed:35301795). {ECO:0000250|UniProtKB:Q9H0I2, ECO:0000269|PubMed:35072334, ECO:0000269|PubMed:35197565, ECO:0000269|PubMed:35301795}.
uniprot
proteins
mass_dalton
38967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
35072334
uniprot
proteins
pubmed
35197565
uniprot
proteins
pubmed
35301795
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:35301795}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:35301795}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:35301795}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9H0I2}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9H0I2}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9H0I2}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9H0I2}. Note=Localized at the centrosome and accumulates at the parental centrioles during centriole duplication in cycling cells (By similarity). In ciliated cells, detected at the basal body of the cilium (By similarity). Localizes to the centrosome during interphase, to the primary cilium at G0, to the spindle poles during mitosis and to the centrosomes and central spindle during telophase and cytokinesis (By similarity). {ECO:0000250|UniProtKB:Q9H0I2}.
uniprot
proteins