KLF8
entrez
11279
canonical
uniprot
O95600
canonical
ensembl
ENSG00000102349
resolver
ensp
ENSP00000364063
resolver
ensp
ENSP00000417303
resolver
ensp
ENSP00000431911
resolver
ensp
ENSP00000492126
resolver
ensp
ENSP00000686812
resolver
enst
ENST00000358094
resolver
genesymbol
KLF8
resolver
genesymbol_syn
BKLF3
resolver
genesymbol_syn
ZNF741
resolver
hgnc
HGNC:6351
resolver
uniprot
B4DJN3
resolver
uniprot
E7EQQ8
resolver
uniprot
F6WDJ1
resolver
uniprot
L0R3U8
resolver
uniprot
L0R4U2
resolver
uniprot
Q05BZ3
resolver
uniprot
Q2M246
resolver
uniprot
Q59GV5
resolver
uniprot
Q5HYQ5
resolver
uniprot
Q5JXP7
resolver
uniprot
Q6MZJ7
resolver
uniprot
Q9UGC4
resolver
uniprot_entry
F6WDJ1_HUMAN
resolver
uniprot_entry
KLF8_HUMAN
resolver
uniprot_entry
Q05BZ3_HUMAN
resolver
uniprot_sec
B4DJN3
resolver
uniprot_sec
E7EQQ8
resolver
uniprot_sec
L0R3U8
resolver
uniprot_sec
L0R4U2
resolver
uniprot_sec
Q2M246
resolver
uniprot_sec
Q59GV5
resolver
uniprot_sec
Q5HYQ5
resolver
uniprot_sec
Q5JXP7
resolver
uniprot_sec
Q6MZJ7
resolver
uniprot_sec
Q9UGC4
resolver
amino_acid_sequence
MVDMDKLINNLEVQLNSEGGSMQVFKQVTASVRNRDPPEIEYRSNMTSPTLLDANPMENPALFNDIKIEPPEELLASDFSLPQVEPVDLSFHKPKAPLQPASMLQAPIRPPKPQSSPQTLVVSTSTSDMSTSANIPTVLTPGSVLTSSQSTGSQQILHVIHTIPSVSLPNKMGGLKTIPVVVQSLPMVYTTLPADGGPAAITVPLIGGDGKNAGSVKVDPTSMSPLEIPSDSEESTIESGSSALQSLQGLQQEPAAMAQMQGEESLDLKRRRIHQCDFAGCSKVYTKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDELTRHFRKHTGIKPFRCTDCNRSFSRSDHLSLHRRRHDTM
uniprot
proteins
function
FUNCTION: Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). {ECO:0000269|PubMed:10756197, ECO:0000269|PubMed:12820964, ECO:0000269|PubMed:16617055}.
uniprot
proteins
mass_dalton
39314
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="K->R: Abolishes sumoylation. No change in nuclear location. Increases transcriptional activity and cell cycle progression. Abolishes sumoylation; when associated with R-217."; /evidence="ECO:0000269|PubMed:16617055"; MUTAGEN 217; /note="K->R: No change in sumoylation. Abolishes sumoylation; when associated with R-67."; /evidence="ECO:0000269|PubMed:16617055
uniprot
proteins
post_translational_modification
PTM: Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G(1) phase. Has no effect on subcellular location. {ECO:0000269|PubMed:16617055}.
uniprot
proteins
protein_family
Sp1 C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
10756197
uniprot
proteins
pubmed
12820964
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16617055
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23134681
uniprot
proteins
pubmed
31375868
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16617055}.
uniprot
proteins