NFAT5
entrez
10725
canonical
uniprot
O94916
canonical
ensembl
ENSG00000102908
resolver
ensp
ENSP00000338806
resolver
ensp
ENSP00000346420
resolver
ensp
ENSP00000457593
resolver
ensp
ENSP00000566514
resolver
genesymbol
NFAT5
resolver
genesymbol_syn
KIAA0827
resolver
genesymbol_syn
TONEBP
resolver
hgnc
HGNC:7774
resolver
uniprot
A2RRB4
resolver
uniprot
A6H8V5
resolver
uniprot
E9PHR7
resolver
uniprot
O95693
resolver
uniprot
Q7LA65
resolver
uniprot
Q969Q8
resolver
uniprot
Q96QH3
resolver
uniprot
Q9UN18
resolver
uniprot_entry
NFAT5_HUMAN
resolver
uniprot_sec
A2RRB4
resolver
uniprot_sec
A6H8V5
resolver
uniprot_sec
E9PHR7
resolver
uniprot_sec
O95693
resolver
uniprot_sec
Q7LA65
resolver
uniprot_sec
Q969Q8
resolver
uniprot_sec
Q96QH3
resolver
uniprot_sec
Q9UN18
resolver
amino_acid_sequence
MPSDFISLLSADLDLESPKSLYSRESVYDLLPKELQLPPSRETSVASMSQTSGGEAGSPPPAVVAADASSAPSSSSMGGACSSFTTSSSPTIYSTSVTDSKAMQVESCSSAVGVSNRGVSEKQLTSNTVQQHPSTPKRHTVLYISPPPEDLLDNSRMSCQDEGCGLESEQSCSMWMEDSPSNFSNMSTSSYNDNTEVPRKSRKRNPKQRPGVKRRDCEESNMDIFDADSAKAPHYVLSQLTTDNKGNSKAGNGTLENQKGTGVKKSPMLCGQYPVKSEGKELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVKPHGFYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEARIGIAGSKKKSTRARLVFRVNIMRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSDENSWKSEAEIDMELFHQNHLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDPAAAGALNVNVKKEISSPARPCSFEEAMKAMKTTGCNLDKVNIIPNALMTPLIPSSMIKSEDVTPMEVTAEKRSSTIFKTTKSVGSTQQTLENISNIAGNGSFSSPSSSHLPSENEKQQQIQPKAYNPETLTTIQTQDISQPGTFPAVSASSQLPNSDALLQQATQFQTRETQSREILQSDGTVVNLSQLTEASQQQQQSPLQEQAQTLQQQISSNIFPSPNSVSQLQNTIQQLQAGSFTGSTASGSSGSVDLVQQVLEAQQQLSSVLFSAPDGNENVQEQLSADIFQQVSQIQSGVSPGMFSSTEPTVHTRPDNLLPGRAESVHPQSENTLSNQQQQQQQQQQVMESSAAMVMEMQQSICQAAAQIQSELFPSTASANGNLQQSPVYQQTSHMMSALSTNEDMQMQCELFSSPPAVSGNETSTTTTQQVATPGTTMFQTSSSGDGEETGTQAKQIQNSVFQTMVQMQHSGDNQPQVNLFSSTKSMMSVQNSGTQQQGNGLFQQGNEMMSLQSGNFLQQSSHSQAQLFHPQNPIADAQNLSQETQGSLFHSPNPIVHSQTSTTSSEQMQPPMFHSQSTIAVLQGSSVPQDQQSTNIFLSQSPMNNLQTNTVAQEAFFAAPNSISPLQSTSNSEQQAAFQQQAPISHIQTPMLSQEQAQPPQQGLFQPQVALGSLPPNPMPQSQQGTMFQSQHSIVAMQSNSPSQEQQQQQQQQQQQQQQQQQSILFSNQNTMATMASPKQPPPNMIFNPNQNPMANQEQQNQSIFHQQSNMAPMNQEQQPMQFQSQSTVSSLQNPGPTQSESSQTPLFHSSPQIQLVQGSPSSQEQQVTLFLSPASMSALQTSINQQDMQQSPLYSPQNNMPGIQGATSSPQPQATLFHNTAGGTMNQLQNSPGSSQQTSGMFLFGIQNNCSQLLTSGPATLPDQLMAISQPGQPQNEGQPPVTTLLSQQMPENSPLASSINTNQNIEKIDLLVSLQNQGNNLTGSF
uniprot
proteins
function
FUNCTION: Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes (PubMed:10377394, PubMed:11485737, PubMed:41652173). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394, PubMed:11485737). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:11485737, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:41652173}.
uniprot
proteins
mass_dalton
165763
uniprot
proteins
mutagenesis
MUTAGEN 120; /note="S->A: Normal nuclear localization."; /evidence="ECO:0000269|PubMed:21209322"; MUTAGEN 134; /note="S->A: Reduced nuclear localization."; /evidence="ECO:0000269|PubMed:21209322"; MUTAGEN 135; /note="T->A: Reduced nuclear localization."; /evidence="ECO:0000269|PubMed:21209322"; MUTAGEN 155; /note="S->A: Increased nuclear localization."; /evidence="ECO:0000269|PubMed:21209322"; MUTAGEN 293..296; /note="RARY->AARA: In DB mut2 mutant; abolished DNA-binding without affecting dimerization."; /evidence="ECO:0000269|PubMed:11485737"; MUTAGEN 298..302; /note="TEGSR->AAGSA: In DB mut1 mutant; abolished DNA-binding without affecting dimerization."; /evidence="ECO:0000269|PubMed:11485737"; MUTAGEN 464..466; /note="FLI->ALA: In DIM mut1 mutant; abolihed dimerization and ability to activate transcription."; /evidence="ECO:0000269|PubMed:11485737"; MUTAGEN 500..506; /note="HQNHLIV->AQHNLAA: In DIM mut2 mutant; abolihed dimerization and ability to activate transcription."; /evidence="ECO:0000269|PubMed:11485737
uniprot
proteins
post_translational_modification
PTM: Phosphorylated (PubMed:10377394). Phosphorylated at Thr-135 by CDK5 in response to osmotic stress; this phosphorylation mediates its rapid nuclear localization (PubMed:21209322). {ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:21209322}.; PTM: Poly-ADP-ribosylated by PARP1 in response to DNA damage, promoting recruitment to sites of R-loop-associated DNA damage. {ECO:0000269|PubMed:34049076}.
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
10051678
uniprot
proteins
pubmed
10377394
uniprot
proteins
pubmed
10565538
uniprot
proteins
pubmed
11233530
uniprot
proteins
pubmed
11485737
uniprot
proteins
pubmed
11528118
uniprot
proteins
pubmed
11780147
uniprot
proteins
pubmed
11934689
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21209322
uniprot
proteins
pubmed
22266867
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
34049076
uniprot
proteins
pubmed
41652173
uniprot
proteins
sequence_length
1531
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10377394}. Cytoplasm {ECO:0000250|UniProtKB:Q9WV30}. Chromosome {ECO:0000269|PubMed:34049076}. Note=Nuclear distribution increases under hypertonic conditions (By similarity). Recruited to sites of R-loop-associated DNA damage following poly-ADP-ribosylation by PARP1 (PubMed:34049076). {ECO:0000250|UniProtKB:Q9WV30, ECO:0000269|PubMed:34049076}.
uniprot
proteins