Plpp6
entrez
74411
canonical
uniprot
Q9D4F2
canonical
ensembl
ENSMUSG00000040105
resolver
ensp
ENSMUSP00000047776
resolver
enst
ENSMUST00000045674
resolver
genesymbol
Plpp6
resolver
uniprot_entry
PLPP6_MOUSE
resolver
amino_acid_sequence
MPSPRRTIEGRPLGSSGGSSVPGSPAHGGGSGGGRFEFQSLLNCRAGADPACARLRASDSPVHRRGSFPLAASGPAQAAPAPPPEDARMNLNPSFLGIALRSLLAIDLWLSKKLGVCAGESSAWGSVRPLMKLLEISGHGIPWLLGTLYCLLRSDSWAGREVLMNLLFALLLDLLLVAVIKGLVRRRRPAHNQKDMFFTLSVDRYSFPSGHATRAALVSRFILNHLVLAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVAFGFFLGYMQYSIVDYCWLSPHNVPVLFVLWNQQ
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
ec_number
3.6.1.68
uniprot
proteins
function
FUNCTION: Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates. Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation. May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway. May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins. Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols. May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate. {ECO:0000250|UniProtKB:Q8IY26}.
uniprot
proteins
mass_dalton
31744
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PKC activates the phosphatase activity towards presqualene diphosphate. {ECO:0000250|UniProtKB:Q8IY26}.
uniprot
proteins
protein_family
PA-phosphatase related phosphoesterase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8IY26}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IY26}. Nucleus envelope {ECO:0000250|UniProtKB:Q8IY26}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q8IY26}.
uniprot
proteins
transmembrane_region
TRANSMEM 132..152; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 162..182; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 226..246; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins