Nono
entrez
53610
canonical
uniprot
Q99K48
canonical
ensembl
ENSMUSG00000031311
resolver
ensp
ENSMUSP00000033673
resolver
ensp
ENSMUSP00000166333
resolver
ensp
ENSMUSP00000346845
resolver
genesymbol
Nono
resolver
uniprot
Q4FK11
resolver
uniprot
Q63887
resolver
uniprot
Q9CYQ4
resolver
uniprot
Q9DBP2
resolver
uniprot_entry
NONO_MOUSE
resolver
uniprot_entry
Q4FK11_MOUSE
resolver
uniprot_sec
Q63887
resolver
uniprot_sec
Q9CYQ4
resolver
uniprot_sec
Q9DBP2
resolver
amino_acid_sequence
MQSNKAFNLEKQNHTPRKHHQHHHQQHHQQQQQQQQQQPPPPIPANGQQASSQNEGLTIDLKNFRKPGEKTFTQRSRLFVGNLPPDITEEEMRKLFEKYGKAGEVFIHKDKGFGFIRLETRTLAEIAKVELDNMPLRGKQLRVRFACHSASLTVRNLPQYVSNELLEEAFSVFGQVERAVVIVDDRGRPSGKGIVEFSGKPAARKALDRCSEGSFLLTTFPRPVTVEPMDQLDDEEGLPEKLVIKNQQFHKEREQPPRFAQPGSFEYEYAMRWKALIEMEKQQQDQVDRNIKEAREKLEMEMEAARHEHQVMLMRQDLMRRQEELRRMEELHNQEVQKRKQLELRQEEERRRREEEMRRQQEEMMRRQQEGFKGTFPDAREQEIRMGQMAMGGAMGINNRGAMPPAPVPPGTPAPPGPATMMPDGTLGLTPPTTERFGQAATMEGIGAIGGTPPAFNRPAPGAEFAPNKRRRY
uniprot
proteins
function
FUNCTION: DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA (PubMed:8355702). Also binds single-stranded DNA and RNA at a site independent of the duplex site (By similarity). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (By similarity). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (By similarity). Together with PSPC1, required for the formation of nuclear paraspeckles (By similarity). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (By similarity). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (By similarity). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (By similarity). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (By similarity). NONO is involved in transcriptional regulation (By similarity). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (PubMed:9001221). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (PubMed:22966205). Important for the functional organization of GABAergic synapses (PubMed:26571461). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (PubMed:26571461). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (PubMed:32286661). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity). {ECO:0000250|UniProtKB:Q15233, ECO:0000269|PubMed:22966205, ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:32286661, ECO:0000269|PubMed:8355702, ECO:0000269|PubMed:9001221}.
uniprot
proteins
mass_dalton
54541
uniprot
proteins
pubmed
12522145
uniprot
proteins
pubmed
15140795
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15860628
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22966205
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
26571461
uniprot
proteins
pubmed
32286661
uniprot
proteins
pubmed
8355702
uniprot
proteins
pubmed
8626664
uniprot
proteins
pubmed
9001221
uniprot
proteins
sequence_length
473
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15860628, ECO:0000269|PubMed:26571461}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q15233}. Nucleus speckle {ECO:0000250|UniProtKB:Q15233}. Chromosome {ECO:0000269|PubMed:32286661}. Note=Detected in punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. {ECO:0000250|UniProtKB:Q15233}.
uniprot
proteins