KDM4D
entrez
55693
canonical
uniprot
Q6B0I6
canonical
ensembl
ENSG00000186280
resolver
ensp
ENSP00000334181
resolver
ensp
ENSP00000460897
resolver
ensp
ENSP00000482224
resolver
enst
ENST00000335080
resolver
enst
ENST00000536741
resolver
enst
ENST00000610872
resolver
genesymbol
KDM4D
resolver
genesymbol_syn
JHDM3D
resolver
genesymbol_syn
JMJD2D
resolver
hgnc
HGNC:25498
resolver
uniprot
B3KPC4
resolver
uniprot
Q0VF39
resolver
uniprot
Q9NT41
resolver
uniprot
Q9NW76
resolver
uniprot_entry
KDM4D_HUMAN
resolver
uniprot_sec
B3KPC4
resolver
uniprot_sec
Q0VF39
resolver
uniprot_sec
Q9NT41
resolver
uniprot_sec
Q9NW76
resolver
amino_acid_sequence
METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELSTQKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRAAAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLAGTTCTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWAPVP
uniprot
proteins
ec_number
1.14.11.66
uniprot
proteins
function
FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:35145029}.
uniprot
proteins
mass_dalton
58603
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated via 'Lys-63'-linked ubiquitin chains. Deubiquitinated by USP14 with the help of TRIM14 leading to stabilization. {ECO:0000269|PubMed:35145029}.
uniprot
proteins
protein_family
JHDM3 histone demethylase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15138608
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16603238
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23102699
uniprot
proteins
pubmed
26741168
uniprot
proteins
pubmed
35145029
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:35145029}.
uniprot
proteins