Cd55b
entrez
13137
canonical
uniprot
Q61476
canonical
ensembl
ENSMUSG00000026401
resolver
ensp
ENSMUSP00000108107
resolver
ensp
ENSMUSP00000113352
resolver
ensp
ENSMUSP00000358096
resolver
enst
ENSMUST00000112488
resolver
enst
ENSMUST00000119432
resolver
genesymbol
Cd55b
resolver
genesymbol_syn
Daf2
resolver
uniprot
E9Q731
resolver
uniprot
E9QAP4
resolver
uniprot
E9QLT3
resolver
uniprot_entry
DAF2_MOUSE
resolver
uniprot_entry
E9Q731_MOUSE
resolver
uniprot_entry
E9QAP4_MOUSE
resolver
uniprot_sec
E9QLT3
resolver
amino_acid_sequence
MVSSTWGYDPRAGAGDLVITTTAAGAVTIAVLLFQTVCGDCGPPPDIPNARPILGRHSKFAEQSKVAYSCNNGFKQVPDKSNIVVCLENGQWSSHETFCEKSCDTPERLSFASLKKEYFNMNFFPVGTIVEYECRPGFRKQPSLSGKSTCLEDLVWSPVAQFCKKKSCPNPKDLDNGHINIPTGILFGSEINFSCNPGYRLVGITSILCTIIGNTVDWDDEFPVCTEIFCPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSKSDVGQWSSPPPQCIEESKVPIKKPVVNVPSTGIPSTPQKPTTESVPNPGDQPTPQKPSTVKVPATQHEPDTTTRTSTDKGESNSGGDRYIYGFVAVIAMIDSLIIVKTLWTILSPNRRSDFQGKERKDVSK
uniprot
proteins
function
FUNCTION: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage. {ECO:0000250|UniProtKB:P08174}.
uniprot
proteins
mass_dalton
44511
uniprot
proteins
protein_family
Receptors of complement activation (RCA) family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7545711
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 369..389; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins