Pwwp2a
entrez
70802
canonical
uniprot
Q69Z61
canonical
ensembl
ENSMUSG00000044950
resolver
ensp
ENSMUSP00000054154
resolver
ensp
ENSMUSP00000091852
resolver
ensp
ENSMUSP00000183613
resolver
ensp
ENSMUSP00000183615
resolver
ensp
ENSMUSP00000183621
resolver
ensp
ENSMUSP00000183623
resolver
genesymbol
Pwwp2a
resolver
genesymbol_syn
Kiaa1935
resolver
uniprot
A2AJK9
resolver
uniprot
A2AJL0
resolver
uniprot
Q3TBG3
resolver
uniprot
Q9CUT9
resolver
uniprot_entry
PWP2A_MOUSE
resolver
uniprot_sec
A2AJK9
resolver
uniprot_sec
A2AJL0
resolver
uniprot_sec
Q3TBG3
resolver
uniprot_sec
Q9CUT9
resolver
amino_acid_sequence
MAAVAAEAAATAASPGEGGAGEAEPELEPIPGSEAGTPLPVTATEAAVPDGEADGRQSAPQADEQPLPPPPPPPPPGELADSSEAEEAKPPEPAAVPVSPPEQPPAAPEQPEDAPRPPPAPALVPPAGGDSAVSHLIPGSEVRVTLDHIIEDALVVSFRLGEKLFSGVLMDLSKRFGPHGIPVTVFPKREYKDKPDAMQLQSTTFQEGIEVKQEVNGAVPDDLSPVPPPERLWASKPPPLFHEGAPYPPPLFIRDTYNQSIPQPPPRKIKRPKRKMYREEPTSIMNAIKLRPRQVLCDKCKNSVVAEKKEIRKGSSDSSRYEDKKRRNDSVATVNKKLKTDHKVDGKNQNESQRRNTVVRVSSIAHSRGRVVKVSAQANTSKAQLNTKKVLQSKNMDHAKAREVLKIAKEKAQKKQSETSTSKTAHAKVHFTRRYQSPSSGSLPPRVRLKPQRYRNEENDSSLKTGLEKIRSGKLAPKPQSRCTSTRSAGEAPSEKPSPSEGPEESAGEVQDTSRVRVPGEQEELRMLGKKGSKSSISVYLTLNQETSDSSSASVCSIDSMDDLKSSNSECSSSESFVFPPGCMHAPSASSTSTSFSSKEENSLRNSLKMKIFSKNVSKCITPDGRTICVGDIVWAKIYGFPWWPARILTITVSRKDNGLLARQEARISWFASPTTSSLALSQLSPFLENFQLRFNKKRKGLYRRAITEAAKAAKQLTPEVRALLTQFET
uniprot
proteins
function
FUNCTION: Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:33235983). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (By similarity). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (PubMed:30228260, PubMed:33235983). Essential for proper mitosis progression (By similarity). {ECO:0000250|UniProtKB:Q96N64, ECO:0000269|PubMed:30228260, ECO:0000269|PubMed:33235983}.
uniprot
proteins
mass_dalton
79388
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
30228260
uniprot
proteins
pubmed
33235983
uniprot
proteins
sequence_length
730
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96N64}.
uniprot
proteins