P70473
uniprot
P70473
canonical
amino_acid_sequence
MALRGVRVLELAGLAPGPFCGMILADFGAEVVLVDRLGSVNHPSHLARGKRSLALDLKRSPGAAVLRRMCARADVLLEPFRCGVMEKLQLGPETLRQDNPKLIYARLSGFGQSGIFSKVAGHDINYVALSGVLSKIGRSGENPYPPLNLLADFGGGGLMCTLGILLALFERTRSGLGQVIDANMVEGTAYLSTFLWKTQAMGLWAQPRGQNLLDGGAPFYTTYKTADGEFMAVGAIEPQFYTLLLKGLGLESEELPSQMSIEDWPEMKKKFADVFARKTKAEWCQIFDGTDACVTPVLTLEEALHHQHNRERGSFITDEEQHACPRPAPQLSRTPAVPSAKRDPSVGEHTVEVLKDYGFSQEEIHQLHSDRIIESNKLKANL
uniprot
proteins
ec_number
5.1.99.4
uniprot
proteins
function
FUNCTION: Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:8020470, PubMed:9106621). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:8020470, PubMed:9106621). {ECO:0000269|PubMed:8020470, ECO:0000269|PubMed:9106621}.
uniprot
proteins
mass_dalton
41828
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; bile acid biosynthesis.; PATHWAY: Lipid metabolism; fatty acid metabolism.
uniprot
proteins
protein_family
CoA-transferase III family
uniprot
proteins
pubmed
10770938
uniprot
proteins
pubmed
11060359
uniprot
proteins
pubmed
7649182
uniprot
proteins
pubmed
8020470
uniprot
proteins
pubmed
8615858
uniprot
proteins
pubmed
9106621
uniprot
proteins
pubmed
9307041
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:11060359}. Mitochondrion {ECO:0000269|PubMed:11060359, ECO:0000269|PubMed:7649182}.
uniprot
proteins