Tomm20
entrez
266601
canonical
uniprot
Q62760
canonical
ensembl
ENSRNOG00000019980
resolver
ensembl
ENSRNOG00055005434
resolver
ensembl
ENSRNOG00060005145
resolver
ensembl
ENSRNOG00065019302
resolver
ensp
ENSRNOP00000027088
resolver
ensp
ENSRNOP00055006641
resolver
ensp
ENSRNOP00060006424
resolver
ensp
ENSRNOP00065025937
resolver
enst
ENSRNOT00000027088
resolver
enst
ENSRNOT00055008742
resolver
enst
ENSRNOT00060008567
resolver
enst
ENSRNOT00065032496
resolver
genesymbol
Tomm20
resolver
uniprot
O08517
resolver
uniprot
Q63804
resolver
uniprot
Q6AZ66
resolver
uniprot_entry
TOM20_RAT
resolver
uniprot_sec
O08517
resolver
uniprot_sec
Q63804
resolver
uniprot_sec
Q6AZ66
resolver
amino_acid_sequence
MVGRNSAIAAGVCGALFIGYCIYFDRKRRSDPNFKNRLRERRKKQKLAKERAGLSKLPDLKDAEAVQKFFLEEIQLGEELLAQGDYEKGVDHLTNAIAVCGQPQQLLQVLQQTLPPPVFQMLLTKLPTISQRIVSAQSLAEDDVE
uniprot
proteins
function
FUNCTION: Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with TOMM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (PubMed:19401463). {ECO:0000250|UniProtKB:Q15388, ECO:0000269|PubMed:19401463}.
uniprot
proteins
mass_dalton
16284
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. {ECO:0000250|UniProtKB:Q15388}.
uniprot
proteins
protein_family
Tom20 family
uniprot
proteins
pubmed
10721992
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19401463
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
29934347
uniprot
proteins
sequence_length
145
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q15388}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q15388}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..24; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q15388
uniprot
proteins