Nolc1
entrez
70769
canonical
uniprot
E9Q5C9
canonical
ensembl
ENSMUSG00000015176
resolver
ensp
ENSMUSP00000128331
resolver
ensp
ENSMUSP00000153329
resolver
ensp
ENSMUSP00000153545
resolver
ensp
ENSMUSP00000297653
resolver
enst
ENSMUST00000223728
resolver
enst
ENSMUST00000225780
resolver
genesymbol
Nolc1
resolver
genesymbol_syn
Kiaa0035
resolver
uniprot
A0A286YDA2
resolver
uniprot
A0A286YDT3
resolver
uniprot
Q3TKZ9
resolver
uniprot
Q3U6W2
resolver
uniprot
Q3UBB6
resolver
uniprot
Q3UI16
resolver
uniprot
Q6ZQK6
resolver
uniprot
Q8CE21
resolver
uniprot_entry
A0A286YDA2_MOUSE
resolver
uniprot_entry
A0A286YDT3_MOUSE
resolver
uniprot_entry
NOLC1_MOUSE
resolver
uniprot_sec
Q3TKZ9
resolver
uniprot_sec
Q3U6W2
resolver
uniprot_sec
Q3UBB6
resolver
uniprot_sec
Q3UI16
resolver
uniprot_sec
Q6ZQK6
resolver
uniprot_sec
Q8CE21
resolver
amino_acid_sequence
MADTGLRRVVPSDLYPLVLRFLRDSQLSEVASKFAKATGATQQDANASSLLDIYSFWLNRSTKAPKVKLQSNGPVTKKAKKETSSSDSSEDSSEDEDKKAQGLPTQKAAAQVKRASVPQHAGKAAAKASESSSSEESSEEEEEDKKKKPVQQKAAKPQAKAVRPPAKKAESSESDSDSDSDSSSEEETPQTQKPKAAVAAKAQTKAEAKPGTPAKAQPKVANGKAAASSSSSSSSDDSEEEKKAAAPPKKTVPKKQVVAKAPVKVAAAPTQKSSSSEDSSSEEEEGQRQPMKKKAGPYSSVPPPSVPLPKKSPGTQAPKKAAAQTQPADSSDDSSDDSDSSSEEEKKPPAKTVVSKTPAKAAPVKKKAESSSDSSDSDSSEDEAPAKPVSTTKSPKPAVTPKPSAAKAVTTPKQPAGSNQKPQSRKADSSSSEEESSSSEEEEASKKSATTPKAKVTAKAAPAKQAPQAAGDSSSDSDSSSSEEEEKTPKPPAKKKAAGGAVSTPAPGKKAEAKSSSSSSSSSSEDSSEEEKKKKPKATTPKIQASKANGTPASLNGKAAKESEEEEEEEETEEKKKAAGTKPGSGKKRKQNETADEATTPQAKKVKLETPNTFPKRKKGERRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGSISVQVNSVKFDSE
uniprot
proteins
function
FUNCTION: Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (By similarity). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (By similarity). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:11424213). It has intrinsic GTPase and ATPase activities (By similarity). {ECO:0000250|UniProtKB:Q14978, ECO:0000269|PubMed:11424213}.
uniprot
proteins
mass_dalton
73698
uniprot
proteins
mutagenesis
MUTAGEN 77..98; /note="KKAKKETSSSDSSEDSSEDEDK->AAAAAETSSSDSSEDSSEDEDA: Strongly reduced pyrophosphorylation."; /evidence="ECO:0000269|PubMed:15604408"; MUTAGEN 83; /note="T->A: Does not affect pyrophosphorylation."; /evidence="ECO:0000269|PubMed:17873058"; MUTAGEN 84..89; /note="SSSDSS->AAADAA: Abolished pyrophosphorylation."; /evidence="ECO:0000269|PubMed:15604408"; MUTAGEN 87..97; /note="DSSEDSSEDED->NSSQNSSQQQN: Strongly reduced pyrophosphorylation."; /evidence="ECO:0000269|PubMed:15604408
uniprot
proteins
post_translational_modification
PTM: Undergoes rapid and massive phosphorylation/dephosphorylation cycles on CK2 and PKC sites. NOLC1 is one of the mostly phosphorylated proteins in the cell. {ECO:0000250|UniProtKB:Q14978}.; PTM: Pyrophosphorylated by 5-diphosphoinositol pentakisphosphate (5-IP7) (PubMed:15604408). Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue (PubMed:15604408, PubMed:17873058). {ECO:0000269|PubMed:15604408, ECO:0000269|PubMed:17873058}.; PTM: Ubiquitinated. Monoubiquitination by the BCR(KBTBD8) complex promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. {ECO:0000250|UniProtKB:Q14978}.
uniprot
proteins
protein_family
NOLC1 family
uniprot
proteins
pubmed
11424213
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15604408
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17873058
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
702
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q14978}. Cytoplasm {ECO:0000250|UniProtKB:Q14978}. Note=Shuttles between the nucleolus and the cytoplasm. At telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase. {ECO:0000250|UniProtKB:Q14978}.
uniprot
proteins