Pbld1
entrez
68371
canonical
uniprot
Q9DCG6
canonical
ensembl
ENSMUSG00000112129
resolver
ensp
ENSMUSP00000136589
resolver
enst
ENSMUST00000178684
resolver
genesymbol
Pbld1
resolver
genesymbol_syn
Mawbp2
resolver
genesymbol_syn
Pbld
resolver
uniprot
Q8VCF3
resolver
uniprot_entry
PBLD1_MOUSE
resolver
uniprot_sec
Q8VCF3
resolver
amino_acid_sequence
MKLPIFIADAFTATAFRGNPAAVCLLERTLEEDAHQQIAREMNLSETAFIRKLQPTDSFTQSSRFGLRWFTPVSEVPLCGHATLASAAVLFHKIQNRNSTLTFVTMSGELKARRAEDGIVLDFPVYPTFPQDFHEVEDLIKAAIGDTLVQDIRYSTDTRKLLVRLSDSYDRSFLESLKVNTEPLPAIEKTGKVRGLILTVKGEPGGQTAPYDFYSRYFAPWVGIAEDPVTGSAHTVLSSYWSQQLRKKEMRAFQCSRRGGELDISLRPDGRVDIKGGAVIVLEGTLTA
uniprot
proteins
function
FUNCTION: Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication (PubMed:39362857, PubMed:39779683). Enhances IRF3-mediated innate immune signaling and promotes apoptotic cell death, thereby suppressing viral replication. Facilitates virus-induced type I interferon (IFN-I) signaling by promoting IRF3 phosphorylation. Up-regulates the type I interferon (IFN-I) response by activating the NF-kappaB signaling pathway (PubMed:34059646). This may occur through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection (By similarity). {ECO:0000250|UniProtKB:P30039, ECO:0000269|PubMed:34059646, ECO:0000269|PubMed:39362857, ECO:0000269|PubMed:39779683}.
uniprot
proteins
mass_dalton
32048
uniprot
proteins
protein_family
PhzF family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34059646
uniprot
proteins
pubmed
39362857
uniprot
proteins
pubmed
39589880
uniprot
proteins
pubmed
39779683
uniprot
proteins
sequence_length
288
uniprot
proteins