Ints5
entrez
109077
canonical
uniprot
Q8CHT3
canonical
ensembl
ENSMUSG00000071652
resolver
ensp
ENSMUSP00000093968
resolver
enst
ENSMUST00000096249
resolver
genesymbol
Ints5
resolver
uniprot
Q3TM44
resolver
uniprot_entry
INT5_MOUSE
resolver
uniprot_sec
Q3TM44
resolver
amino_acid_sequence
MSALCDPPGAPGPPGPAPATHGPAPLSAQELSQEIKAFLTGVDPILGHQLSAREHARCGLLLLRSLPPARAAVLDHLRGVFDESVRAHLAALEESPVAGPPHLRPPPPSHVPTGGPGLEDVVHEVQQVLCEFIRANPKAWAPVISAWSIDLMGQLSSTYSGQHQRVPHATGSLNELLQLWMGCRATRTLMDIYVQCLSALIGSCPDACVDALLDTSVQHSPHFDWVVAHIGSSFPGTIISRVLSCGLKDFCVHSGAGGGASACGNSSQPPSTDPFPGSPAIPGEKRVPKIASVVGILGHLASRHGDSIRRELLRMFHDSLAGGSGGRNGEPSLQATVPFLLQLAVMSPALLGTVSGELVDCLKPPAVLSQLQQHLQGFPREELDNMLNLAVHLVSQASGTGAYRLLQFLVDTAMPASVITTQGLAVPDTVREACDRLIQLLLLHLQKLVHHRGGSPGEGVLGPPPPPRPVPFLDALRNHVGELCGETLRLERKRFLWQHQLLGLLSVYTRPSCGPEALGHLLSRARSPEELSLATQLYAGLVVSLSGLLPLAFRSCLARVHAGTLQPPFTARFLRNLALLVGWEQQGGEGPSALGARFGESASAHLADLAPLLLHPEEEVAEAAASLLAICPFPSEALSPSQLLGLVRAGVHHFFSSLRLHGPPGVASASQLLTRLSQTSPAGLKAVLQLLVEGALHRGNTELFGGEMDGDNETLSIVSTPLASASLLDINRRHTAAVPGPGGIWSVFHAGVIGRGLKPPKIVQSRNHQEVIYNTQSLVSLLVHCCSASGNSEREGCWGAPTLSPEAAKAVAVTLVESVCPDAAGAELAWPPEDHARATVERDLRIGRRFREQPLLFELLKLVAAAPPALCYCSVLLRGLLAALLSHWEASRHPDTTHSPWHLEASCILVAVMAEGSLLPPALGNMHEVFSQLAPFEVRLLLLSVWGFLREHGPLPQKFIFQSERGRFIRDFAREGGAEGGPHLSVLHSVLHRNIDRLGLFSGRFQAPPPSTLLRQGT
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex. {ECO:0000250|UniProtKB:Q6P9B9}.
uniprot
proteins
mass_dalton
108348
uniprot
proteins
protein_family
Integrator subunit 5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
1018
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6P9B9}. Cytoplasm {ECO:0000250|UniProtKB:Q6P9B9}. Nucleus membrane {ECO:0000250|UniProtKB:Q6P9B9}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 533..553; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 855..875; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 929..949; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins