Abce1
entrez
24015
canonical
uniprot
P61222
canonical
ensembl
ENSMUSG00000058355
resolver
ensp
ENSMUSP00000079379
resolver
enst
ENSMUST00000080536
resolver
genesymbol
Abce1
resolver
genesymbol_syn
Rli
resolver
uniprot
O88793
resolver
uniprot
Q13181
resolver
uniprot
Q13864
resolver
uniprot
Q3TJM9
resolver
uniprot
Q3UHY8
resolver
uniprot
Q96AL0
resolver
uniprot
Q96B10
resolver
uniprot
Q99K66
resolver
uniprot_entry
ABCE1_MOUSE
resolver
uniprot_entry
Q3TJM9_MOUSE
resolver
uniprot_entry
Q3UHY8_MOUSE
resolver
uniprot_sec
O88793
resolver
uniprot_sec
Q13181
resolver
uniprot_sec
Q13864
resolver
uniprot_sec
Q96AL0
resolver
uniprot_sec
Q96B10
resolver
uniprot_sec
Q99K66
resolver
amino_acid_sequence
MADKLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQSKIAWISETLCIGCGICIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVTMPFSVREGINIFLDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKSTGSVRQLLHEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLEITFRRDPNNYRPRINKLNSIKDVEQKKSGNYFFLDD
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (By similarity). Able to hydrolyze ATP, GTP, UTP and CTP (By similarity). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (By similarity). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (By similarity). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (By similarity). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (By similarity). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (By similarity). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:10866653). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (By similarity). {ECO:0000250|UniProtKB:P61221, ECO:0000269|PubMed:10866653}.
uniprot
proteins
mass_dalton
67314
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by CNOT4 (By similarity). Ubiquitination mediates the recruitment of autophagy receptors to the mitochondrial outer membrane and initiates mitophagy (By similarity). {ECO:0000250|UniProtKB:P61221}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCE family
uniprot
proteins
pubmed
10866653
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9524254
uniprot
proteins
sequence_length
599
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P61221}. Mitochondrion {ECO:0000250|UniProtKB:P61221}.
uniprot
proteins