ATF6B
entrez
1388
canonical
uniprot
Q99941
canonical
ensembl
ENSG00000168468
resolver
ensembl
ENSG00000213676
resolver
ensembl
ENSG00000228628
resolver
ensembl
ENSG00000234539
resolver
ensp
ENSP00000364347
resolver
ensp
ENSP00000364349
resolver
genesymbol
ATF6B
resolver
genesymbol_syn
CREBL1
resolver
genesymbol_syn
G13
resolver
hgnc
HGNC:2349
resolver
uniprot
B0UYX6
resolver
uniprot
Q13269
resolver
uniprot
Q14343
resolver
uniprot
Q14345
resolver
uniprot
Q5SSW7
resolver
uniprot
Q6AZW6
resolver
uniprot
Q99635
resolver
uniprot
Q99637
resolver
uniprot
Q9H3V9
resolver
uniprot
Q9H3W1
resolver
uniprot
Q9NPL0
resolver
uniprot_entry
ATF6B_HUMAN
resolver
uniprot_entry
Q6AZW6_HUMAN
resolver
uniprot_sec
B0UYX6
resolver
uniprot_sec
Q13269
resolver
uniprot_sec
Q14343
resolver
uniprot_sec
Q14345
resolver
uniprot_sec
Q5SSW7
resolver
uniprot_sec
Q99635
resolver
uniprot_sec
Q99637
resolver
uniprot_sec
Q9H3V9
resolver
uniprot_sec
Q9H3W1
resolver
uniprot_sec
Q9NPL0
resolver
amino_acid_sequence
MAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQVKSEPSSPCSSSSLSSESSRLSTEPSSEALGVGEVLHVKTESLAPPLCLLGDDPTSSFETVQINVIPTSDDSSDVQTKIEPVSPCSSVNSEASLLSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPSLGAVQISMGPSLDGSSGKALPTRKPPLQPKPVVLTTVPMPSRAVPPSTTVLLQSLVQPPPVSPVVLIQGAIRVQPEGPAPSLPRPERKSIVPAPMPGNSCPPEVDAKLLKRQQRMIKNRESACQSRRKKKEYLQGLEARLQAVLADNQQLRRENAALRRRLEALLAENSELKLGSGNRKVVCIMVFLLFIAFNFGPVSISEPPSAPISPRMNKGEPQPRRHLLGFSEQEPVQGVEPLQGSSQGPKEPQPSPTDQPSFSNLTAFPGGAKELLLRDLDQLFLSSDCRHFNRTESLRLADELSGWVQRHQRGRRKIPQRAQERQKSQPRKKSPPVKAVPIQPPGPPERDSVGQLQLYRHPDRSQPAFLDAIDRREDTFYVVSFRRDHLLLPAISHNKTSRPKMSLVMPAMAPNETLSGRGAPGDYEEMMQIECEVMDTRVIHIKTSTVPPSLRKQPSPTPGNATGGPLPVSAASQAHQASHQPLYLNHP
uniprot
proteins
function
FUNCTION: [Cyclic AMP-dependent transcription factor ATF-6 beta]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane (PubMed:11256944). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:11256944). {ECO:0000269|PubMed:11256944}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress (PubMed:11256944). Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE (PubMed:11256944). {ECO:0000269|PubMed:11256944}.
uniprot
proteins
mass_dalton
76709
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:11256944}.; PTM: During unfolded protein response, a fragment of approximately 60 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 (MBTPS1, S1P) and site-2 (MBTPS2, S2P) proteases. {ECO:0000305|PubMed:11256944}.
uniprot
proteins
protein_family
ATF subfamily
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
11256944
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
8586413
uniprot
proteins
pubmed
8870652
uniprot
proteins
pubmed
8923003
uniprot
proteins
sequence_length
703
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11256944}; Single-pass type II membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Nucleus {ECO:0000269|PubMed:11256944}. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. {ECO:0000269|PubMed:11256944}.
uniprot
proteins
transmembrane_region
TRANSMEM 397..417; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins