SPAG8
entrez
26206
canonical
uniprot
Q99932
canonical
ensembl
ENSG00000137098
resolver
ensp
ENSP00000340982
resolver
ensp
ENSP00000379878
resolver
ensp
ENSP00000541910
resolver
ensp
ENSP00000644423
resolver
genesymbol
SPAG8
resolver
hgnc
HGNC:14105
resolver
uniprot
A0A140VJV0
resolver
uniprot
B4DY89
resolver
uniprot
E9PDV6
resolver
uniprot
Q12937
resolver
uniprot
Q5TCV8
resolver
uniprot
Q8WWB4
resolver
uniprot_entry
A0A140VJV0_HUMAN
resolver
uniprot_entry
SPAG8_HUMAN
resolver
uniprot_sec
B4DY89
resolver
uniprot_sec
E9PDV6
resolver
uniprot_sec
Q12937
resolver
uniprot_sec
Q5TCV8
resolver
uniprot_sec
Q8WWB4
resolver
amino_acid_sequence
METNESTEGSRSRSRSLDIQPSSEGLGPTSEPFPSSDDSPRSALAAATAAAAAAASAAAATAAFTTAKAAALSTKTPAPCSEFMEPSSDPSLLGEPCAGPGFTHNIAHGSLGFEPVYVSCIAQDTCTTTDHSSNPGPVPGSSSGPVLGSSSGAGHGSGSGSGPGCGSVPGSGSGPGPGSGPGSGPGHGSGSHPGPASGPGPDTGPDSELSPCIPPGFRNLVADRVPNYTSWSQHCPWEPQKQPPWEFLQVLEPGARGLWKPPDIKGKLMVCYETLPRGQCLLYNWEEERATNHLDQVPSMQDGSESFFFRHGHRGLLTMQLKSPMPSSTTQKDSYQPPGNVYWPLRGKREAMLEMLLQHQICKEVQAEQEPTRKLFEVESVTHHDYRMELAQAGTPAPTKPHDYRQEQPETFWIQRAPQLPGVSNIRTLDTPFRKNCSFSTPVPLSLGKLLPYEPENYPYQLGEISSLPCPGGRLGGGGGRMTPF
uniprot
proteins
function
FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (PubMed:19548270). May play a role in fertility and microtubule formation through interaction with RANBP9 (PubMed:10500252). {ECO:0000250|UniProtKB:Q3V0Q6, ECO:0000269|PubMed:10500252, ECO:0000269|PubMed:19548270, ECO:0000269|PubMed:36191189}.
uniprot
proteins
mass_dalton
51139
uniprot
proteins
protein_family
SPAG8 family
uniprot
proteins
pubmed
10500252
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15014887
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17187156
uniprot
proteins
pubmed
19548270
uniprot
proteins
pubmed
36191189
uniprot
proteins
pubmed
38538594
uniprot
proteins
pubmed
8788182
uniprot
proteins
sequence_length
485
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3V0Q6}. Nucleus {ECO:0000250|UniProtKB:Q3V0Q6}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:15014887, ECO:0000269|PubMed:17187156, ECO:0000269|PubMed:8788182}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:19548270}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19548270}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q3V0Q6}. Note=In mature sperm cells, detected in the acrosomal region of the head and in the middle piece of the tail (By similarity). Localized to the nucleus and cytoplasm of spermatocytes and round spermatids while, in elongating spermatids, expressed in the cytoplasm but not in the nucleus (By similarity). During the cell cycle, localized on the microtubule-organizing center (MTOC) during prophase. In metaphase, extends along spindle microtubules. In anaphase, detected on the astral microtubules and mid-zone. In telophase, remains at the mid-zone. After cytokinesis, returns to the MTOC (PubMed:19548270). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme (By similarity). {ECO:0000250|UniProtKB:E1BNS6, ECO:0000250|UniProtKB:Q3V0Q6, ECO:0000269|PubMed:19548270}.
uniprot
proteins