Slc29a4
entrez
243328
canonical
uniprot
Q8R139
canonical
ensembl
ENSMUSG00000050822
resolver
ensp
ENSMUSP00000059896
resolver
ensp
ENSMUSP00000228057
resolver
enst
ENSMUST00000058418
resolver
genesymbol
Slc29a4
resolver
genesymbol_syn
Ent4
resolver
genesymbol_syn
pmat
resolver
uniprot_entry
S29A4_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated at acidic pH. {ECO:0000269|PubMed:16873718}.
uniprot
proteins
amino_acid_sequence
MGSIGSQRLKEPCVAATSDQSVVTSFSFDNFQLETTAEGAQDPGIRVRGVPTFTDSAVEEPVPDDRYHAIYFAMLLAGVGFLLPYNSFITDVDYLHHKYPGTSIVFDMSLTYILVALAAVLLNNVVVERLNLHTRITTGYLLALGPLLFISICDVWLQLFSHDQAYAINLAAVGTVAFGCTVQQSSFYGYTGLLPKRYTQGVMTGESTAGVMISLSRILTKLLLPDERASTIIFFLVSAGLELLCFLLHLLVRRSRFVLYYTTRPRDSRPVQAGYRVHHDVASGDIHFEHQTPALSSSRSPKESPAHEVTHSNSGVYMRFDVPRPRVKRSWPTFRALLLHRYVVARVIWADMLSIAVTYFITLCLFPGLESEIRHCVLGEWLPILVMAVFNLSDFVGKILAALPVEWRGTHLLACSCLRVVFIPLFILCVYPSGMPALRHPAWPCVFSLLMGISNGYFGSVPMILAAGKVSPKQRELAGNTMTVSYMSGLTLGSAVAYCTYSLTRDAHGSCFQTATAAAANDSIPVGP
uniprot
proteins
function
FUNCTION: Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs (PubMed:16873718, PubMed:23255610). Utilizes the physiologic inside-negative membrane potential as a driving force to facilitate cellular uptake of organic cations (By similarity). Functions as a Na(+)- and Cl(-)-independent bidirectional transporter (By similarity). Substrate transport is pH-dependent and enhanced under acidic condition, which is most likely the result of allosteric changes in the transporter structure (PubMed:16873718). Implicated in monoamine neurotransmitters uptake such as serotonin, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the central nervous system (PubMed:23255610). Also responsible for the uptake of bioactive amines and drugs through the blood-cerebrospinal fluid (CSF) barrier, from the CSF into choroid plexus epithelial cells, thereby playing a significant role in the clearance of cationic neurotoxins, xenobiotics and metabolic waste in the brain (PubMed:23255610). Involved in bidirectional transport of the purine nucleoside adenosine and plays a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia (PubMed:16873718). May be involved in organic cation uptake from the tubular lumen into renal tubular cells, thereby contributing to organic cation reabsorption in the kidney (PubMed:23255610). Also transports adenine and guanidine (PubMed:16873718). {ECO:0000250|UniProtKB:Q7RTT9, ECO:0000269|PubMed:16873718, ECO:0000269|PubMed:23255610}.
uniprot
proteins
mass_dalton
58099
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:16873718}.
uniprot
proteins
protein_family
SLC29A/ENT transporter (TC 2.A.57) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16873718
uniprot
proteins
pubmed
23255610
uniprot
proteins
sequence_length
528
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7RTT9}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:23255610}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the apical blood-cerebrospinal fluid(CSF)-facing membrane of the choroid plexus epithelium. {ECO:0000269|PubMed:23255610}.
uniprot
proteins
transmembrane_region
TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 347..367; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 412..432; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 446..466; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 482..504; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins