NSFL1C
entrez
55968
canonical
uniprot
Q9UNZ2
canonical
ensembl
ENSG00000088833
resolver
ensp
ENSP00000216879
resolver
ensp
ENSP00000338643
resolver
ensp
ENSP00000418529
resolver
ensp
ENSP00000434067
resolver
genesymbol
NSFL1C
resolver
genesymbol_syn
UBXN2C
resolver
hgnc
HGNC:15912
resolver
uniprot
A2A2L1
resolver
uniprot
B2RD74
resolver
uniprot
Q53FE8
resolver
uniprot
Q5JXA4
resolver
uniprot
Q5JXA5
resolver
uniprot
Q7Z533
resolver
uniprot
Q9H102
resolver
uniprot
Q9NVL9
resolver
uniprot
Q9UI06
resolver
uniprot_entry
NSF1C_HUMAN
resolver
uniprot_entry
Q53FE8_HUMAN
resolver
uniprot_sec
A2A2L1
resolver
uniprot_sec
B2RD74
resolver
uniprot_sec
Q5JXA4
resolver
uniprot_sec
Q5JXA5
resolver
uniprot_sec
Q7Z533
resolver
uniprot_sec
Q9H102
resolver
uniprot_sec
Q9NVL9
resolver
uniprot_sec
Q9UI06
resolver
amino_acid_sequence
MAAERQEALREFVAVTGAEEDRARFFLESAGWDLQIALASFYEDGGDEDIVTISQATPSSVSRGTAPSDNRVTSFRDLIHDQDEDEEEEEGQRFYAGGSERSGQQIVGPPRKKSPNELVDDLFKGAKEHGAVAVERVTKSPGETSKPRPFAGGGYRLGAAPEEESAYVAGEKRQHSSQDVHVVLKLWKSGFSLDNGELRSYQDPSNAQFLESIRRGEVPAELRRLAHGGQVNLDMEDHRDEDFVKPKGAFKAFTGEGQKLGSTAPQVLSTSSPAQQAENEAKASSSILIDESEPTTNIQIRLADGGRLVQKFNHSHRISDIRLFIVDARPAMAATSFILMTTFPNKELADESQTLKEANLLNAVIVQRLT
uniprot
proteins
function
FUNCTION: Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}.
uniprot
proteins
mass_dalton
40573
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during mitosis. Phosphorylation inhibits interaction with Golgi membranes and is required for the fragmentation of the Golgi stacks during mitosis (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
NSFL1C family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498563
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23649807
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O35987}. Golgi apparatus, Golgi stack {ECO:0000250|UniProtKB:O35987}. Chromosome {ECO:0000250|UniProtKB:O35987}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O35987}. Note=Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks. Localizes to centrosome during mitotic prophase and metaphase. {ECO:0000250|UniProtKB:O35987}.
uniprot
proteins