ARHGAP11B
entrez
89839
canonical
uniprot
Q3KRB8
canonical
ensembl
ENSG00000274734
resolver
ensembl
ENSG00000284906
resolver
ensembl
ENSG00000285077
resolver
ensembl
ENSG00000286139
resolver
ensp
ENSP00000392760
resolver
ensp
ENSP00000457054
resolver
ensp
ENSP00000482099
resolver
ensp
ENSP00000498432
resolver
ensp
ENSP00000498846
resolver
ensp
ENSP00000508838
resolver
ensp
ENSP00000510601
resolver
ensp
ENSP00000513489
resolver
enst
ENST00000428041
resolver
enst
ENST00000563110
resolver
enst
ENST00000621228
resolver
enst
ENST00000650801
resolver
enst
ENST00000651601
resolver
enst
ENST00000685924
resolver
enst
ENST00000693711
resolver
enst
ENST00000697964
resolver
genesymbol
ARHGAP11B
resolver
genesymbol_syn
FAM7B1
resolver
hgnc
HGNC:15782
resolver
uniprot_entry
RHGBB_HUMAN
resolver
amino_acid_sequence
MWDQRLVKLALLQHLRAFYGIKVKGVRGQCDRRRHETAATEIGGKIFGVPFNALPHSAVPEYGHIPSFLVDACTSLEEHIHTEGLFRKSGSVIRLKALKNKVDHGEGCLSSAPPCDIAGLLKQFFRELPEPILPADLHEALLKAQQLGTEEKNKAILLLSCLLADHTVHVLRYFFNFLRNVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSSNAEKKGVYQTLSWKRYQPCWVLMVSVLLHHWKALKKVNMKLLVNIREREDNV
uniprot
proteins
function
FUNCTION: Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex (PubMed:25721503, PubMed:27957544, PubMed:30484771, PubMed:32554627, PubMed:33938018). Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion (PubMed:25721503). Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation (PubMed:31883789). Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development (PubMed:25721503, PubMed:27957544). {ECO:0000269|PubMed:25721503, ECO:0000269|PubMed:27957544, ECO:0000269|PubMed:30484771, ECO:0000269|PubMed:31883789, ECO:0000269|PubMed:32554627, ECO:0000269|PubMed:33938018}.
uniprot
proteins
mass_dalton
30251
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
25721503
uniprot
proteins
pubmed
27957544
uniprot
proteins
pubmed
28580430
uniprot
proteins
pubmed
30484771
uniprot
proteins
pubmed
31883789
uniprot
proteins
pubmed
32554627
uniprot
proteins
pubmed
33938018
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:31883789}.
uniprot
proteins