Rftn1
entrez
76438
canonical
uniprot
Q6A0D4
canonical
ensembl
ENSMUSG00000039316
resolver
ensp
ENSMUSP00000046524
resolver
enst
ENSMUST00000044503
resolver
genesymbol
Rftn1
resolver
genesymbol_syn
Kiaa0084
resolver
uniprot
Q3U654
resolver
uniprot
Q3U8P6
resolver
uniprot
Q80US1
resolver
uniprot_entry
RFTN1_MOUSE
resolver
uniprot_sec
Q3U654
resolver
uniprot_sec
Q3U8P6
resolver
uniprot_sec
Q80US1
resolver
amino_acid_sequence
MGCSLNKLEKREEKRPGNIYSTLKRPQVETKVDVTYEYCFLEFTTLTAAELPRSSATRLASLRDLPDQLLELYQQGFSLAALHPFVQPTRRQEKILLEHIFRAILVKKTNRSQKAELHDEGYTLELDYCSSLEHLADQKLIPEFIKKVQEAASQGLKFVSVVPQYQPSVSSAGSRRLKPVANSVEDARDVKCTLGDRSSLENDTPKAAETDAATAGVNRRPETKPGSTGDVPSAQQPGIPSPSAENEAGEFPLRGLQPALDRSEGDPSNGPEELPSRKMEIFAFFNRPKSQQKCRQYYPVTIPLQVSKNGQTVSSLDASWLEHMSDHFRKGGVLVNAVFQLGMANDSFYGLTDGVFIFEAVSTEDNRTTQGYDAIVVEQWTVLEGTEVQTDYMPLLNSLAAYGWQLTCVLPTPILKTTREGNVSTKQIVFLQRPCLPQKTKKRESKFQWRFSRNEIHGRQTRKSKGKLSASNKQQAEENEKNLEDQFSKAGDVGNCVLGAPQWGRASEVREQRQGSAAVQNGPAGHNRDSVALRHSNPRAEAELAAGPTPTEAN
uniprot
proteins
function
FUNCTION: Involved in protein trafficking via association with clathrin and AP2 complex (By similarity). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages, and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (PubMed:19414744). May regulate B-cell antigen receptor-mediated signaling (By similarity). May play a pivotal role in the formation and/or maintenance of lipid rafts (By similarity). {ECO:0000250|UniProtKB:Q14699, ECO:0000269|PubMed:19414744, ECO:0000269|PubMed:27022195}.
uniprot
proteins
mass_dalton
61537
uniprot
proteins
protein_family
Raftlin family
uniprot
proteins
pubmed
12805216
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19414744
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27022195
uniprot
proteins
sequence_length
554
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19414744}; Lipid-anchor {ECO:0000250|UniProtKB:Q14699}. Cytoplasm {ECO:0000250|UniProtKB:Q14699}. Membrane raft {ECO:0000250|UniProtKB:Q14699}. Endosome {ECO:0000250|UniProtKB:Q14699}. Early endosome {ECO:0000250|UniProtKB:Q14699}. Note=Translocates from cytoplasm to cell membrane where it colocalizes with poly (I:C) and then moves to endosomes where it colocalizes with TLR3. Translocates from cytoplasm to cell membrane where it colocalizes with TLR4 and then together with TLR4 moves to endosomes, upon lipopolysaccharide stimulation (PubMed:27022195). {ECO:0000250|UniProtKB:Q14699}.
uniprot
proteins