Krt6a
entrez
683313
canonical
uniprot
Q4FZU2
canonical
ensembl
ENSRNOG00000070470
resolver
ensp
ENSRNOP00000087976
resolver
enst
ENSRNOT00000102479
resolver
genesymbol
Krt6a
resolver
uniprot_entry
K2C6A_RAT
resolver
amino_acid_sequence
MSTKTVIRSQTSHRGFSAGSARLPGLNRSGFSSVSVCRSRGSGGSRAVCGGAGFGSRSLCGVGSSQRISIGGGSCGIGGGYGGRFGGSFGYGGGAGGSLGFGAGAGFGGGYGGAGFPVCPPGGIQEVTINQSLLTPMNLQIDPTIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWALLQEQGTKTVRQGLETLFEQYINDLRKELDNILGQRGRLDSELRNMQGTVEDYKSKYEDEINRRTAAENEFVTLKKDVDAAYMNKVELQAKADSLTDEINFLRALYEAELSQMQTHISDTSVVLSMDNNRSLDLDSIIAEVKAQYEEIAKRSRAEAESWYQTKYEELQITAGRHGDDLRNTKQEISEINRMIQRLRSEIDHVKKQIANLQAAIAEAEQRGEMALKDARGKLEGLEDALQKAKQDMARLLKEYQDLMNVKLALDVEIATYRTLLEGEECRLNGEGVGPVNISVVQSTVSSSYGSAGGASSSIGLGGSSSFSYGGSHSIGGGFSAGSGRGISSGLSSSGGSSSTIKYTTTSSTRKSYRP
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in epithelial keratinocytes. Forms heteropolymers with the type I keratins KRT16 and KRT17, assembling into keratin intermediate filament networks that contribute to the structural integrity and stress resilience of stratified epithelia, particularly in epidermis, nail bed and oral mucosa (By similarity). Rapidly induced in wound-edge keratinocytes and participates in cytoskeletal reorganization during re-epithelialization. Negatively regulates collective keratinocyte migration by stabilizing non-muscle myosin MYH9 and desmoplakin, thereby altering cell-cell and cell-matrix adhesion and reducing the speed and directionality of epithelial sheet movement during wound repair. Also limits epithelial migration by inhibiting SRC activity during wound repair (By similarity). Required for normal plantar and nail unit integrity (By similarity). {ECO:0000250|UniProtKB:P02538, ECO:0000250|UniProtKB:P50446}.
uniprot
proteins
mass_dalton
59249
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
552
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P50446}.
uniprot
proteins