LHCGR
entrez
3973
canonical
uniprot
P22888
canonical
ensembl
ENSG00000138039
resolver
ensp
ENSP00000294954
resolver
ensp
ENSP00000583126
resolver
genesymbol
LHCGR
resolver
genesymbol_syn
LCGR
resolver
genesymbol_syn
LGR2
resolver
genesymbol_syn
LHRHR
resolver
hgnc
HGNC:6585
resolver
uniprot
Q14751
resolver
uniprot
Q15996
resolver
uniprot
Q9UEW9
resolver
uniprot_entry
LSHR_HUMAN
resolver
uniprot_sec
Q14751
resolver
uniprot_sec
Q15996
resolver
uniprot_sec
Q9UEW9
resolver
amino_acid_sequence
MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
uniprot
proteins
disease_involvement
DISEASE: Familial male precocious puberty (FMPP) [MIM:176410]: In FMPP the receptor is constitutively activated. {ECO:0000269|PubMed:11134146, ECO:0000269|PubMed:11391350, ECO:0000269|PubMed:7629248, ECO:0000269|PubMed:7692306, ECO:0000269|PubMed:7714085, ECO:0000269|PubMed:7757065, ECO:0000269|PubMed:7892197, ECO:0000269|PubMed:8281137, ECO:0000269|PubMed:8812739, ECO:0000269|PubMed:8829636, ECO:0000269|PubMed:8929952, ECO:0000269|PubMed:9467560, ECO:0000269|PubMed:9661624, ECO:0000269|PubMed:9973550}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Luteinizing hormone resistance (LHR) [MIM:238320]: An autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. {ECO:0000269|PubMed:12050206, ECO:0000269|PubMed:15372531, ECO:0000269|PubMed:15472221, ECO:0000269|PubMed:19551906, ECO:0000269|PubMed:7719343, ECO:0000269|PubMed:8559204, ECO:0000269|PubMed:9215288, ECO:0000269|PubMed:9514160, ECO:0000269|PubMed:9626144, ECO:0000269|PubMed:9626653}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). {ECO:0000269|PubMed:11847099}.
uniprot
proteins
mass_dalton
78643
uniprot
proteins
mutagenesis
MUTAGEN 331; /note="Y->F: Reduces intracellular cAMP accumulation."; /evidence="ECO:0000269|PubMed:11847099"; MUTAGEN 333; /note="Y->F: No change in intracellular cAMP accumulation."; /evidence="ECO:0000269|PubMed:11847099"; MUTAGEN 643; /note="C->G: Loss of palmitoylation."; /evidence="ECO:0000269|PubMed:15539429"; MUTAGEN 644; /note="C->G: Loss of palmitoylation."; /evidence="ECO:0000269|PubMed:15539429
uniprot
proteins
post_translational_modification
PTM: Sulfated. {ECO:0000269|PubMed:11847099}.
uniprot
proteins
protein_family
FSH/LSH/TSH subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10215412
uniprot
proteins
pubmed
10580072
uniprot
proteins
pubmed
11134146
uniprot
proteins
pubmed
11391350
uniprot
proteins
pubmed
11847099
uniprot
proteins
pubmed
12050206
uniprot
proteins
pubmed
12679452
uniprot
proteins
pubmed
15372531
uniprot
proteins
pubmed
15472221
uniprot
proteins
pubmed
15539429
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
1922095
uniprot
proteins
pubmed
19551906
uniprot
proteins
pubmed
2244890
uniprot
proteins
pubmed
2293030
uniprot
proteins
pubmed
7556872
uniprot
proteins
pubmed
7629248
uniprot
proteins
pubmed
7692306
uniprot
proteins
pubmed
7714085
uniprot
proteins
pubmed
7719343
uniprot
proteins
pubmed
7757065
uniprot
proteins
pubmed
7892197
uniprot
proteins
pubmed
8281137
uniprot
proteins
pubmed
8559204
uniprot
proteins
pubmed
8747461
uniprot
proteins
pubmed
8812739
uniprot
proteins
pubmed
8829636
uniprot
proteins
pubmed
8929952
uniprot
proteins
pubmed
9215288
uniprot
proteins
pubmed
9467560
uniprot
proteins
pubmed
9514160
uniprot
proteins
pubmed
9626144
uniprot
proteins
pubmed
9626653
uniprot
proteins
pubmed
9661624
uniprot
proteins
pubmed
9851790
uniprot
proteins
pubmed
9858858
uniprot
proteins
pubmed
9973550
uniprot
proteins
sequence_length
699
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11847099}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 364..385; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 396..416; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 440..462; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 483..505; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 526..549; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 571..594; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 606..627; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins