Setd4
entrez
224440
canonical
uniprot
P58467
canonical
ensembl
ENSMUSG00000022948
resolver
ensp
ENSMUSP00000023669
resolver
ensp
ENSMUSP00000156553
resolver
ensp
ENSMUSP00000156698
resolver
ensp
ENSMUSP00000156723
resolver
ensp
ENSMUSP00000242260
resolver
ensp
ENSMUSP00000242268
resolver
ensp
ENSMUSP00000242279
resolver
enst
ENSMUST00000023669
resolver
enst
ENSMUST00000233931
resolver
genesymbol
Setd4
resolver
genesymbol_syn
ORF21
resolver
uniprot
G3X9W6
resolver
uniprot_entry
SETD4_MOUSE
resolver
uniprot_sec
G3X9W6
resolver
amino_acid_sequence
MQRRRGRTERARKRRRRSSGSRAVNESYRSEFIELRKWLKERKFEDTDLVPASFPGTGRGLMSKASLQEGQVMISLPESCLLTTDTVIRSSLGPYIKKWKPPVSPLLALCTFLVSEKHAGCRSLWKSYLDILPKSYTCPVCLEPEVVDLLPSPLKAKAEEQRARVQDLFTSARGFFSTLQPLFAEPVDSVFSYRAFLWAWCTVNTRAVYLRSRRQECLSAEPDTCALAPFLDLLNHSPHVQVKAAFNEKTRCYEIRTASRCRKHQEVFICYGPHDNQRLLLEYGFVSVRNPHACVPVSADMLVKFLPAADKQLHRKITILKDHGFTGNLTFGWDGPSWRLLTALKLLCLEAERFTSWKKVLLGEVISDTNEKTSLGVAQKICSDVIEETHAVLRKVSDMKEGTVSLRSQLSLVEALRMEELRILQASAEILSGLLAPFS
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.364
uniprot
proteins
function
FUNCTION: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins (PubMed:31376731, PubMed:31794893, PubMed:33506343). Via its catalytic activity, regulates many processes, including cell proliferation, cell differentiation, inflammatory response and apoptosis. Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of pro-inflammatory cytokines IL6 and TNF (PubMed:31376731). Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (By similarity) (PubMed:33506343). In the brain, epigenetically controls quiescence of neural stem cells for sustaining a protected neural stem cell population and maintaining a stem cell reservoir for neurogenesis (PubMed:36027907). Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (PubMed:33506343). Through the catalysis of XRCC5/Ku70 trimethylation, regulates BAX-mediated apoptosis. SETD4-catalyzed XRCC5 methylation results in XRCC5 translocation to the cytoplasm, where it interacts with BAX, sequestering it from the mitochondria, hence preventing BAX-mediated apoptosis (By similarity). {ECO:0000250|UniProtKB:Q9NVD3, ECO:0000269|PubMed:31376731, ECO:0000269|PubMed:31794893, ECO:0000269|PubMed:33506343, ECO:0000269|PubMed:36027907}.
uniprot
proteins
mass_dalton
49810
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
SETD4 family
uniprot
proteins
pubmed
11707072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
31376731
uniprot
proteins
pubmed
31794893
uniprot
proteins
pubmed
32259569
uniprot
proteins
pubmed
33506343
uniprot
proteins
pubmed
36027907
uniprot
proteins
sequence_length
439
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:31376731}. Nucleus {ECO:0000269|PubMed:31376731}.
uniprot
proteins