AKR1A1
entrez
10327
canonical
uniprot
P14550
canonical
ensembl
ENSG00000117448
resolver
ensp
ENSP00000312606
resolver
ensp
ENSP00000361140
resolver
ensp
ENSP00000480713
resolver
ensp
ENSP00000533996
resolver
ensp
ENSP00000533997
resolver
ensp
ENSP00000533998
resolver
ensp
ENSP00000534005
resolver
ensp
ENSP00000534006
resolver
ensp
ENSP00000534011
resolver
ensp
ENSP00000534012
resolver
ensp
ENSP00000610668
resolver
ensp
ENSP00000632632
resolver
ensp
ENSP00000632633
resolver
ensp
ENSP00000750378
resolver
enst
ENST00000351829
resolver
enst
ENST00000372070
resolver
enst
ENST00000621846
resolver
enst
ENST00000863937
resolver
enst
ENST00000863938
resolver
enst
ENST00000863939
resolver
enst
ENST00000863946
resolver
enst
ENST00000863947
resolver
enst
ENST00000863952
resolver
enst
ENST00000863953
resolver
enst
ENST00000940609
resolver
enst
ENST00000962573
resolver
enst
ENST00000962574
resolver
genesymbol
AKR1A1
resolver
genesymbol
HEL-S-165mP
resolver
genesymbol_syn
ALDR1
resolver
genesymbol_syn
ALR
resolver
genesymbol_syn
HEL-S-6
resolver
hgnc
HGNC:380
resolver
uniprot
A8KAL8
resolver
uniprot
D3DQ04
resolver
uniprot
Q6IAZ4
resolver
uniprot
V9HWI0
resolver
uniprot_entry
AK1A1_HUMAN
resolver
uniprot_entry
V9HWI0_HUMAN
resolver
uniprot_sec
A8KAL8
resolver
uniprot_sec
D3DQ04
resolver
uniprot_sec
Q6IAZ4
resolver
amino_acid_sequence
MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVPRDAGHPLYPFNDPY
uniprot
proteins
ec_number
1.1.1.19
uniprot
proteins
ec_number
1.1.1.2
uniprot
proteins
ec_number
1.1.1.20
uniprot
proteins
ec_number
1.1.1.372
uniprot
proteins
ec_number
1.1.1.54
uniprot
proteins
ec_number
1.6.-.-
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:10510318, PubMed:30538128). Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed:10510318, PubMed:30538128). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes (By similarity). Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic (By similarity). Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) (PubMed:11306097, PubMed:18276838). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (PubMed:30538128). S-nitroso-CoA reductase activity is involved in reprogramming intermediary metabolism in renal proximal tubules, notably by inhibiting protein S-nitrosylation of isoform 2 of PKM (PKM2) (By similarity). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione (PubMed:31649033). Displays no reductase activity towards retinoids (By similarity). {ECO:0000250|UniProtKB:P50578, ECO:0000250|UniProtKB:P51635, ECO:0000269|PubMed:10510318, ECO:0000269|PubMed:11306097, ECO:0000269|PubMed:18276838, ECO:0000269|PubMed:30538128, ECO:0000269|PubMed:31649033}.
uniprot
proteins
mass_dalton
36573
uniprot
proteins
mutagenesis
MUTAGEN 50; /note="Y->A: Abolished reductase activity."; /evidence="ECO:0000269|PubMed:30538128, ECO:0000269|PubMed:31649033"; MUTAGEN 50; /note="Y->F: Complete loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:7669785"; MUTAGEN 50; /note="Y->H: Complete loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:7669785"; MUTAGEN 80; /note="K->M: Complete loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:7669785"; MUTAGEN 113; /note="H->Q: Strong decrease in enzymatic activity."; /evidence="ECO:0000269|PubMed:7669785"; MUTAGEN 127; /note="K->A: Abolished S-nitroso-CoA reductase activity without affecting ability to reduce S-nitrosoglutathione, glyceraldehyde or glucuronate."; /evidence="ECO:0000269|PubMed:30538128, ECO:0000269|PubMed:31649033"; MUTAGEN 299; /note="I->A: No change in enzymatic activity."; /evidence="ECO:0000269|PubMed:7669785"; MUTAGEN 299; /note="I->C: No change in enzymatic activity."; /evidence="ECO:0000269|PubMed:7669785"; MUTAGEN 300; /note="V->C: No change in enzymatic activity."; /evidence="ECO:0000269|PubMed:7669785"; MUTAGEN 312; /note="R->A: Abolished S-nitrosoglutathione reductase activity without affecting ability to reduce S-nitroso-CoA."; /evidence="ECO:0000269|PubMed:31649033
uniprot
proteins
protein_family
Aldo/keto reductase family
uniprot
proteins
pubmed
10393438
uniprot
proteins
pubmed
10486210
uniprot
proteins
pubmed
10510318
uniprot
proteins
pubmed
11306097
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15299353
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18276838
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2498333
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30538128
uniprot
proteins
pubmed
31649033
uniprot
proteins
pubmed
3615425
uniprot
proteins
pubmed
7669785
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JII6}. Apical cell membrane {ECO:0000250|UniProtKB:Q9JII6}.
uniprot
proteins