Nr3c1
entrez
14815
canonical
uniprot
P06537
canonical
ensembl
ENSMUSG00000024431
resolver
ensp
ENSMUSP00000025300
resolver
ensp
ENSMUSP00000095199
resolver
ensp
ENSMUSP00000111229
resolver
ensp
ENSMUSP00000111233
resolver
genesymbol
Nr3c1
resolver
genesymbol_syn
Grl
resolver
genesymbol_syn
Grl1
resolver
uniprot
E0ZPU5
resolver
uniprot
E9PUR6
resolver
uniprot
E9PYV1
resolver
uniprot
Q06VW2
resolver
uniprot
Q3U126
resolver
uniprot
Q3U2M7
resolver
uniprot
Q61628
resolver
uniprot
Q61629
resolver
uniprot_entry
GCR_MOUSE
resolver
uniprot_sec
E0ZPU5
resolver
uniprot_sec
E9PUR6
resolver
uniprot_sec
E9PYV1
resolver
uniprot_sec
Q06VW2
resolver
uniprot_sec
Q3U126
resolver
uniprot_sec
Q3U2M7
resolver
uniprot_sec
Q61628
resolver
uniprot_sec
Q61629
resolver
amino_acid_sequence
MDSKESLAPPGRDEVPSSLLGRGRGSVMDLYKTLRGGATVKVSASSPSVAAASQADSKQQRILLDFSKGSASNAQQQQQQQQQQQQQQQQQPQPDLSKAVSLSMGLYMGETETKVMGNDLGYPQQGQLGLSSGETDFRLLEESIANLNRSTSRPENPKSSTPAAGCATPTEKEFPQTHSDPSSEQQNRKSQPGTNGGSVKLYTTDQSTFDILQDLEFSAGSPGKETNESPWRSDLLIDENLLSPLAGEDDPFLLEGDVNEDCKPLILPDTKPKIQDTGDTILSSPSSVALPQVKTEKDDFIELCTPGVIKQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPVFNVIPPIPVGSENWNRCQGSGEDNLTSLGAMNFAGRSVFSNGYSSPGMRPDVSSPPSSSSTATGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENANKTIVPAALPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQASGNLLCFAPDLIINEQRMTLPCMYDQCKHMLFISTELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHDVVENLLSYCFQTFLDKSMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
uniprot
proteins
function
FUNCTION: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:10678832). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (PubMed:15037546). {ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:10678832, ECO:0000269|PubMed:15037546}.; FUNCTION: [Isoform 1]: Has transcriptional activation and repression activity (By similarity). Mediates glucocorticoid-induced apoptosis (By similarity). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (PubMed:21994940). {ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:21994940, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform 3]: Acts as a dominant negative inhibitor of isoform 1 (PubMed:20660300). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (By similarity). Loses this transcription modulator function on its own (By similarity). Has no hormone-binding activity (PubMed:20660300). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (PubMed:20660300). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (By similarity). Directly regulates STAT1 expression in isoform Alpha-independent manner (By similarity). {ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:20660300}.
uniprot
proteins
mass_dalton
87164
uniprot
proteins
mutagenesis
MUTAGEN 1; /note="M->T: Abolishes expression of A-type isoforms."; /evidence="ECO:0000269|PubMed:11435610"; MUTAGEN 28; /note="M->T: Abolishes expression of B-type isoforms. 1-B."; /evidence="ECO:0000269|PubMed:11435610"; MUTAGEN 435; /note="K->A: Abolishes glucocorticoid-mediated degradation and enhances transcription trans-activation."; /evidence="ECO:0000269|PubMed:11555652"; MUTAGEN 493; /note="R->A: Abolishes transactivation activity."; /evidence="ECO:0000269|PubMed:25676786"; MUTAGEN 493; /note="R->C: Abolishes transcriptional activity. Does not impair ligand binding."; /evidence="ECO:0000269|PubMed:25676786"; MUTAGEN 493; /note="R->K: Does not change transactivation activity."; /evidence="ECO:0000269|PubMed:25676786
uniprot
proteins
post_translational_modification
PTM: Acetylation by CLOCK reduces its binding to glucocorticoid response elements and its transcriptional activity. {ECO:0000250|UniProtKB:P04150}.; PTM: Increased proteasome-mediated degradation in response to glucocorticoids. {ECO:0000269|PubMed:11555652}.; PTM: Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoids. Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-221, Ser-243 and Ser-421-phosphorylated forms are mainly cytoplasmic, and the Ser-229-phosphorylated form is nuclear (By similarity). Phosphorylation at Ser-229 increases transcriptional activity (By similarity). Phosphorylation at Ser-221, Ser-243 and Ser-421 decreases signaling capacity (By similarity). Phosphorylation at Ser-421 may protect from glucocorticoid-induced apoptosis (By similarity). Phosphorylation at Ser-221 and Ser-229 is not required in regulation of chromosome segregation (By similarity). May be dephosphorylated by PPP5C, attenuates NR3C1 action (PubMed:21994940). {ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:2019585, ECO:0000269|PubMed:21994940}.; PTM: Sumoylation at Lys-294 and Lys-310 negatively regulates its transcriptional activity. Sumoylation at Lys-718 positively regulates its transcriptional activity in the presence of RWDD3. Sumoylation at Lys-294 and Lys-310 is dispensable whereas sumoylation at Lys-718 is critical for the stimulatory effect of RWDD3 on its transcriptional activity. Heat shock increases sumoylation in a RWDD3-dependent manner. {ECO:0000250|UniProtKB:P06536}.; PTM: Ubiquitinated (PubMed:11555652). Ubiquitination by UBR5 leads to its degradation: UBR5 specifically recognizes and binds ligand-bound NR3C1 when it is not associated with coactivators (NCOAs) (By similarity). In presence of NCOAs, the UBR5-degron is not accessible, preventing its ubiquitination and degradation (By similarity). {ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:11555652}.
uniprot
proteins
protein_family
NR3 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10678832
uniprot
proteins
pubmed
10848625
uniprot
proteins
pubmed
11278753
uniprot
proteins
pubmed
11435610
uniprot
proteins
pubmed
11555652
uniprot
proteins
pubmed
11751894
uniprot
proteins
pubmed
12949501
uniprot
proteins
pubmed
15037546
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17012242
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
2019585
uniprot
proteins
pubmed
20660300
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21994940
uniprot
proteins
pubmed
22170608
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24736997
uniprot
proteins
pubmed
25676786
uniprot
proteins
pubmed
25847991
uniprot
proteins
pubmed
2702670
uniprot
proteins
pubmed
27686098
uniprot
proteins
pubmed
28751364
uniprot
proteins
pubmed
2911477
uniprot
proteins
pubmed
30698747
uniprot
proteins
pubmed
3780669
uniprot
proteins
pubmed
9195923
uniprot
proteins
pubmed
9528750
uniprot
proteins
pubmed
9742105
uniprot
proteins
sequence_length
792
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11278753, ECO:0000269|PubMed:25676786, ECO:0000269|PubMed:27686098}. Nucleus {ECO:0000269|PubMed:10678832, ECO:0000269|PubMed:11278753, ECO:0000269|PubMed:25676786, ECO:0000269|PubMed:27686098}. Mitochondrion {ECO:0000250|UniProtKB:P04150}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P04150}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P04150}. Chromosome {ECO:0000269|PubMed:30698747}. Nucleus, nucleoplasm {ECO:0000269|PubMed:10678832}. Note=After ligand activation, translocates from the cytoplasm to the nucleus (PubMed:11278753). The hormone-occupied receptor undergoes rapid exchange between chromatin and the nucleoplasmic compartment (PubMed:10678832). In the presence of NR1D1 shows a time-dependent subcellular localization, localizing to the cytoplasm at ZT8 and to the nucleus at ZT20 (PubMed:27686098). Lacks this diurnal pattern of localization in the absence of NR1D1, localizing to both nucleus and the cytoplasm at ZT8 and ZT20 (PubMed:27686098). Upon dexamethasone binding associates with the glucocorticoid response elements of target genes (PubMed:30698747). {ECO:0000269|PubMed:10678832, ECO:0000269|PubMed:11278753, ECO:0000269|PubMed:27686098, ECO:0000269|PubMed:30698747}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:P04150}. Nucleus {ECO:0000250|UniProtKB:P04150}. Mitochondrion {ECO:0000250|UniProtKB:P04150}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P04150}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P04150}. Note=After ligand activation, translocates from the cytoplasm to the nucleus. {ECO:0000250|UniProtKB:P04150}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:20660300}. Cytoplasm {ECO:0000269|PubMed:20660300}. Note=Expressed predominantly in the nucleus with some expression also detected in the cytoplasm. {ECO:0000269|PubMed:20660300}.
uniprot
proteins