TRIM22
entrez
10346
canonical
uniprot
Q8IYM9
canonical
ensembl
ENSG00000132274
resolver
ensp
ENSP00000369299
resolver
genesymbol
TRIM22
resolver
genesymbol_syn
RNF94
resolver
genesymbol_syn
STAF50
resolver
hgnc
HGNC:16379
resolver
uniprot
B4DQS5
resolver
uniprot
Q05CQ0
resolver
uniprot
Q15521
resolver
uniprot_entry
B4DQS5_HUMAN
resolver
uniprot_entry
TRI22_HUMAN
resolver
uniprot_sec
Q05CQ0
resolver
uniprot_sec
Q15521
resolver
amino_acid_sequence
MDFSVKVDIEKEVTCPICLELLTEPLSLDCGHSFCQACITAKIKESVIISRGESSCPVCQTRFQPGNLRPNRHLANIVERVKEVKMSPQEGQKRDVCEHHGKKLQIFCKEDGKVICWVCELSQEHQGHQTFRINEVVKECQEKLQVALQRLIKEDQEAEKLEDDIRQERTAWKNYIQIERQKILKGFNEMRVILDNEEQRELQKLEEGEVNVLDNLAAATDQLVQQRQDASTLISDLQRRLRGSSVEMLQDVIDVMKRSESWTLKKPKSVSKKLKSVFRVPDLSGMLQVLKELTDVQYYWVDVMLNPGSATSNVAISVDQRQVKTVRTCTFKNSNPCDFSAFGVFGCQYFSSGKYYWEVDVSGKIAWILGVHSKISSLNKRKSSGFAFDPSVNYSKVYSRYRPQYGYWVIGLQNTCEYNAFEDSSSSDPKVLTLFMAVPPCRIGVFLDYEAGIVSFFNVTNHGALIYKFSGCRFSRPAYPYFNPWNCLVPMTVCPPSS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Interferon-induced E3 ubiquitin ligase that plays important roles in innate and adaptive immunity (PubMed:25683609, PubMed:35777501). Restricts the replication of many viruses including HIV-1, encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), hepatitis C virus (HCV) or Zika virus (ZIKV) (PubMed:25683609, PubMed:35777501, PubMed:36042495). Mechanistically, negatively regulates HCV replication by promoting ubiquitination and subsequent degradation of viral NS5A (PubMed:25683609). Also acts by promoting the degradation of Zika virus NS1 and NS3 proteins through proteasomal degradation (PubMed:36042495). Acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 binding to the HIV-1 promoter (PubMed:26683615). Also plays a role in antiviral immunity by co-regulating together with NT5C2 the RIGI/NF-kappa-B pathway by promoting 'Lys-63'-linked ubiquitination of RIGI, while NT5C2 is responsible for 'Lys-48'-linked ubiquitination of RIGI (PubMed:36159777). Participates in adaptive immunity by suppressing the amount of MHC class II protein in a negative feedback manner in order to limit the extent of MHC class II induction (PubMed:35777501). {ECO:0000269|PubMed:18389079, ECO:0000269|PubMed:18656448, ECO:0000269|PubMed:19218198, ECO:0000269|PubMed:19585648, ECO:0000269|PubMed:25683609, ECO:0000269|PubMed:26683615, ECO:0000269|PubMed:35777501, ECO:0000269|PubMed:36042495, ECO:0000269|PubMed:36159777}.
uniprot
proteins
mass_dalton
56947
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="C->A: Loss of E3 ubiquitin-protein ligase activity, reduces auto-ubiquitination and not affect nuclear bodies formation. Loss of antiviral activity; when associated with A-18."; /evidence="ECO:0000269|PubMed:18389079, ECO:0000269|PubMed:18656448, ECO:0000269|PubMed:19481078"; MUTAGEN 18; /note="C->A: Loss of antiviral activity and not affect nuclear bodies formation; when associated with A-15."; /evidence="ECO:0000269|PubMed:18389079, ECO:0000269|PubMed:19481078"; MUTAGEN 493..494; /note="VC->AA: Reduces formation of regular nuclear bodies."; /evidence="ECO:0000269|PubMed:19481078
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000269|PubMed:18656448}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
15064739
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17156811
uniprot
proteins
pubmed
18389079
uniprot
proteins
pubmed
18656448
uniprot
proteins
pubmed
19218198
uniprot
proteins
pubmed
19331816
uniprot
proteins
pubmed
19481078
uniprot
proteins
pubmed
19585648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25683609
uniprot
proteins
pubmed
26683615
uniprot
proteins
pubmed
35777501
uniprot
proteins
pubmed
36042495
uniprot
proteins
pubmed
36159777
uniprot
proteins
pubmed
7797467
uniprot
proteins
sequence_length
498
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:25683609}. Nucleus {ECO:0000269|PubMed:17156811}. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.
uniprot
proteins