Fbxo31
entrez
498959
canonical
uniprot
B2RYN2
canonical
ensembl
ENSRNOG00000042274
resolver
ensembl
ENSRNOG00055020702
resolver
ensembl
ENSRNOG00060017555
resolver
ensembl
ENSRNOG00065006359
resolver
ensp
ENSRNOP00000063581
resolver
ensp
ENSRNOP00000070481
resolver
ensp
ENSRNOP00055028666
resolver
ensp
ENSRNOP00060024233
resolver
ensp
ENSRNOP00065007072
resolver
enst
ENSRNOT00000068764
resolver
enst
ENSRNOT00000079651
resolver
enst
ENSRNOT00055035364
resolver
enst
ENSRNOT00060030027
resolver
enst
ENSRNOT00065009766
resolver
genesymbol
Fbxo31
resolver
uniprot
A0A8L2R3E7
resolver
uniprot_entry
A0A8L2R3E7_RAT
resolver
uniprot_entry
FBX31_RAT
resolver
amino_acid_sequence
MAVCARLCGVGPARGCRRRQQRRGPAETAAADSEADTDPEEERIEAGPARCSLLELPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKLLHRYRHILGLWQPDIGPYGGLLNVVVDGLFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVECMYGHKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQEEFRTWLREEWGRTLEDIFHEHMQELILMKFIYTSQYDNCLTYRRIYLPPSHPDDLIKPGLFKGTYGSHGLEIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLQRRIQLPDVENLRNFNELSRIVLEVREQVRQEQEAGEGPAPHREPAVKDPEGPPAKASKEAGPGAEAAEQSSTSGQGQPFVLPAGVSSRNEDYPRTCRLCFYGTGLIAGHGFTSPERTPGVFVLFDEDRFGFLWLELKSFSLYSRVQATFQNADAPSPQAFDEMLRNIQSLTS
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF(FBXO31) protein ligase complex, which specifically mediates the ubiquitination of proteins amidated at their C-terminus in response to oxidative stress, leading to their degradation by the proteasome. FBXO31 specifically recognizes and binds C-terminal peptides bearing an amide: C-terminal amidation in response to oxidative stress takes place following protein fragmentation. The SCF(FBXO31) also plays a role in G1 arrest following DNA damage by mediating ubiquitination of phosphorylated cyclin-D1 (CCND1), promoting its degradation by the proteasome, resulting in G1 arrest (By similarity). The SCF(FBXO31) complex is however not a major regulator of CCND1 stability during the G1/S transition (By similarity). In response to genotoxic stress, the SCF(FBXO31) complex directs ubiquitination and degradation of phosphorylated MDM2, thereby promoting p53/TP53-mediated DNA damage response. SCF(FBXO31) complex is required for genomic integrity by catalyzing ubiquitination and degradation of cyclin-A (CCNA1 and/or CCNA2) during the G1 phase. In response to genotoxic stress, the SCF(FBXO31) complex directs ubiquitination and degradation of phosphorylated FBXO46 and MAP2K6. SCF(FBXO31) complex promotes ubiquitination and degradation of CDT1 during the G2 phase to prevent re-replication. The SCF(FBXO31) complex also mediates ubiquitination and degradation of DUSP6, OGT and PARD6A (By similarity). {ECO:0000250|UniProtKB:Q3TQF0, ECO:0000250|UniProtKB:Q5XUX0}.
uniprot
proteins
mass_dalton
57399
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q5XUX0}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-264 by ATM following gamma-irradiation results in its stabilization. Phosphorylation at Ser-448 in absence of stress promotes its ubiquitination and degradation by the SCF(FBXO46) complex. Phosphorylation at Ser-33 by AKT1 promotes association with CDC20 and ubiquitination by the APC/C complex. {ECO:0000250|UniProtKB:Q5XUX0}.; PTM: Ubiquitinated by the SCF(FBXO46) complex in absence of stress, promoting its degradation. Ubiquitinated by the APC/C complex following phosphorylation at Ser-33, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:Q5XUX0}.
uniprot
proteins
protein_family
FBXO31 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23469015
uniprot
proteins
sequence_length
507
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5XUX0}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23469015}.
uniprot
proteins