STYX
entrez
6815
canonical
uniprot
Q8WUJ0
canonical
ensembl
ENSG00000198252
resolver
ensp
ENSP00000346599
resolver
ensp
ENSP00000403214
resolver
ensp
ENSP00000545008
resolver
enst
ENST00000354586
resolver
enst
ENST00000442123
resolver
enst
ENST00000874949
resolver
genesymbol
STYX
resolver
hgnc
HGNC:11447
resolver
uniprot
B9EJG0
resolver
uniprot
Q99850
resolver
uniprot_entry
STYX_HUMAN
resolver
uniprot_sec
B9EJG0
resolver
uniprot_sec
Q99850
resolver
amino_acid_sequence
MEDVKLEFPSLPQCKEDAEEWTYPMRREMQEILPGLFLGPYSSAMKSKLPVLQKHGITHIICIRQNIEANFIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIYLAKLTIQMMSPLQIERSLSVHSGTTGSLKRTHEEEDDFGTMQVATAQNG
uniprot
proteins
function
FUNCTION: Catalytically inactive phosphatase (PubMed:23847209). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (PubMed:28007894). Plays a role in spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q60969, ECO:0000269|PubMed:23847209, ECO:0000269|PubMed:28007894}.
uniprot
proteins
mass_dalton
25492
uniprot
proteins
mutagenesis
MUTAGEN 76..78; /note="FQQ->AAA: Loss of interaction with FBXW7. Does not affect interaction with MAPK1 and nuclear localization."; /evidence="ECO:0000269|PubMed:28007894"; MUTAGEN 120; /note="G->C: Confers phosphatase activity. Dephosphorylates MAPK1. Does not affect interaction with FBXW7 and nuclear localization."; /evidence="ECO:0000269|PubMed:23847209, ECO:0000269|PubMed:28007894"; MUTAGEN 142..144; /note="KYR->AAA: Increases interaction with FBXW7."; /evidence="ECO:0000269|PubMed:28007894
uniprot
proteins
protein_family
Non-receptor class subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18058037
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23847209
uniprot
proteins
pubmed
28007894
uniprot
proteins
pubmed
9633825
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23847209, ECO:0000269|PubMed:28007894}. Cytoplasm, cytosol {ECO:0000269|PubMed:23847209}. Note=Predominantly localizes to the nucleus. {ECO:0000269|PubMed:23847209, ECO:0000269|PubMed:28007894}.
uniprot
proteins