SPRING1
entrez
79794
canonical
uniprot
Q9H741
canonical
ensembl
ENSG00000111412
resolver
ensp
ENSP00000261318
resolver
ensp
ENSP00000790838
resolver
enst
ENST00000261318
resolver
genesymbol
SPRING1
resolver
genesymbol_syn
C12orf49
resolver
genesymbol_syn
SPRING
resolver
hgnc
HGNC:26128
resolver
uniprot
Q53GE8
resolver
uniprot_entry
SPRNG_HUMAN
resolver
uniprot_sec
Q53GE8
resolver
amino_acid_sequence
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQEERAVRDRNLLQVHDHNQPIPWKVQFNLGNSSRPSNQCRNSIQGKHLITDELGYVCERKDLLVNGCCNVNVPSTKQYCCDGCWPNGCCSAYEYCVSCCLQPNKQLLLERFLNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCYGESPPELFPA
uniprot
proteins
function
FUNCTION: Positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP. {ECO:0000269|PubMed:32111832}.
uniprot
proteins
mass_dalton
23594
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="N->Q: Loss of glycosylation."; /evidence="ECO:0000269|PubMed:32111832
uniprot
proteins
protein_family
SPRING family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
32111832
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:32111832}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..35; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins