RIPOR1
entrez
79567
canonical
uniprot
Q6ZS17
canonical
ensembl
ENSG00000039523
resolver
ensp
ENSP00000042381
resolver
ensp
ENSP00000368614
resolver
ensp
ENSP00000389456
resolver
ensp
ENSP00000400099
resolver
ensp
ENSP00000443568
resolver
ensp
ENSP00000531050
resolver
ensp
ENSP00000531054
resolver
enst
ENST00000540839
resolver
genesymbol
RIPOR1
resolver
genesymbol_syn
FAM65A
resolver
genesymbol_syn
KIAA1930
resolver
hgnc
HGNC:25836
resolver
uniprot
A0A0A0MTL6
resolver
uniprot
B4DEQ9
resolver
uniprot
B4DIM2
resolver
uniprot
E9PBS3
resolver
uniprot
Q4G0A4
resolver
uniprot
Q7Z5R7
resolver
uniprot
Q8NDA4
resolver
uniprot
Q96J39
resolver
uniprot
Q96PV8
resolver
uniprot
Q9H8D9
resolver
uniprot_entry
A0A0A0MTL6_HUMAN
resolver
uniprot_entry
RIPR1_HUMAN
resolver
uniprot_sec
B4DEQ9
resolver
uniprot_sec
B4DIM2
resolver
uniprot_sec
E9PBS3
resolver
uniprot_sec
Q4G0A4
resolver
uniprot_sec
Q7Z5R7
resolver
uniprot_sec
Q8NDA4
resolver
uniprot_sec
Q96J39
resolver
uniprot_sec
Q96PV8
resolver
uniprot_sec
Q9H8D9
resolver
amino_acid_sequence
MMSLSVRPQRRLLSARVNRSQSFAGVLGSHERGPSLSFRSFPVFSPPGPPRKPPALSRVSRMFSVAHPAAKVPQPERLDLVYTALKRGLTAYLEVHQQEQEKLQGQIRESKRNSRLGFLYDLDKQVKSIERFLRRLEFHASKIDELYEAYCVQRRLRDGAYNMVRAYTTGSPGSREARDSLAEATRGHREYTESMCLLESELEAQLGEFHLRMKGLAGFARLCVGDQYEICMKYGRQRWKLRGRIEGSGKQVWDSEETIFLPLLTEFLSIKVTELKGLANHVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEVTWSPFDKDDQPSAASSVNKASTVTKRFSTYSQSPPDTPSLREQAFYNMLRRQEELENGTAWSLSSESSDDSSSPQLSGTARHSPAPRPLVQQPEPLPIQVAFRRPETPSSGPLDEEGAVAPVLANGHAPYSRTLSHISEASVDAALAEASVEAVGPESLAWGPSPPTHPAPTHGEHPSPVPPALDPGHSATSSTLGTTGSVPTSTDPAPSAHLDSVHKSTDSGPSELPGPTHTTTGSTYSAITTTHSAPSPLTHTTTGSTHKPIISTLTTTGPTLNIIGPVQTTTSPTHTMPSPTHTTASPTHTSTSPTHTPTSPTHKTSMSPPTTTSPTPSGMGLVQTATSPTHPTTSPTHPTTSPILINVSPSTSLELATLSSPSKHSDPTLPGTDSLPCSPPVSNSYTQADPMAPRTPHPSPAHSSRKPLTSPAPDPSESTVQSLSPTPSPPTPAPQHSDLCLAMAVQTPVPTAAGGSGDRSLEEALGALMAALDDYRGQFPELQGLEQEVTRLESLLMQRQGLTRSRASSLSITVEHALESFSFLNEDEDEDNDVPGDRPPSSPEAGAEDSIDSPSARPLSTGCPALDAALVRHLYHCSRLLLKLGTFGPLRCQEAWALERLLREARVLEAVCEFSRRWEIPASSAQEVVQFSASRPGFLTFWDQCTERLSCFLCPVERVLLTFCNQYGARLSLRQPGLAEAVCVKFLEDALGQKLPRRPQPGPGEQLTVFQFWSFVETLDSPTMEAYVTETAEEVLLVRNLNSDDQAVVLKALRLAPEGRLRRDGLRALSSLLVHGNNKVMAAVSTQLRSLSLGPTFRERALLCFLDQLEDEDVQTRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQCGEEGQSAHRRLEESLDALPRIFGPGSMASTAF
uniprot
proteins
function
FUNCTION: Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269|PubMed:27807006}.
uniprot
proteins
mass_dalton
132308
uniprot
proteins
protein_family
RIPOR family
uniprot
proteins
pubmed
11572484
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27807006
uniprot
proteins
sequence_length
1223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27807006}. Golgi apparatus {ECO:0000269|PubMed:27807006}. Note=Localizes to the podocyte major processes and cell body (By similarity). Colocalized with STK26 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with STK26 upon serum stimulation in a Rho- and PDCD10-dependent manner (PubMed:27807006). {ECO:0000250|UniProtKB:Q68FE6, ECO:0000269|PubMed:27807006}.
uniprot
proteins