Rph3a
entrez
19894
canonical
uniprot
P47708
canonical
ensembl
ENSMUSG00000029608
resolver
ensp
ENSMUSP00000078198
resolver
ensp
ENSMUSP00000143917
resolver
ensp
ENSMUSP00000144291
resolver
ensp
ENSMUSP00000307244
resolver
ensp
ENSMUSP00000307246
resolver
ensp
ENSMUSP00000307252
resolver
ensp
ENSMUSP00000307257
resolver
ensp
ENSMUSP00000307258
resolver
ensp
ENSMUSP00000307269
resolver
ensp
ENSMUSP00000307271
resolver
enst
ENSMUST00000079204
resolver
enst
ENSMUST00000202326
resolver
enst
ENSMUST00000202406
resolver
genesymbol
Rph3a
resolver
uniprot_entry
RP3A_MOUSE
resolver
amino_acid_sequence
MTDTVVNRWMYPGDGPLQSNDKEQLQAGWSVHPGAQTDRQRKQEELTDEEKEIINRVIARAEKMEAMEQERIGRLVDRLETMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKKNVCTKCGVETSNNRPHPVWLCKICLEQREVWKRSGAWFFKGFPKQVLPQPMPIKKTKPQQPAGEPATQEQPTPESRHPARAPARGDMEDRRPPGQKPGPDLTSAPGRGSHGPPTRRASEARMSTAARDSEGWDHAHGGGTGDTSRSPAGLRRANSVQAARPAPAPVPSPAPPQPVQPGPPGGSRATPGPGRFPEQSTEAPPSDPGYPGAVAPAREERTGPAGGFQAAPHTAAPYSQAAPARQPPPAEEEEEEANSYDSDEATTLGALEFSLLYDQDNSNLQCTIIRAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPVWNETLQYHGITEEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKANQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERIGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNENHVSSD
uniprot
proteins
function
FUNCTION: Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity). {ECO:0000250|UniProtKB:P47709}.
uniprot
proteins
mass_dalton
75489
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Deubiquitinated by CAND1 to prevent its degradation. {ECO:0000250|UniProtKB:P47709}.
uniprot
proteins
pubmed
10407024
uniprot
proteins
pubmed
12578829
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
18945677
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
7822236
uniprot
proteins
sequence_length
681
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P47709}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P47709}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P47709}. Membrane {ECO:0000250|UniProtKB:P47709}; Peripheral membrane protein {ECO:0000250|UniProtKB:P47709}.
uniprot
proteins