APOBEC1
entrez
339
canonical
uniprot
P41238
canonical
ensembl
ENSG00000111701
resolver
ensp
ENSP00000229304
resolver
enst
ENST00000229304
resolver
genesymbol
APOBEC1
resolver
hgnc
HGNC:604
resolver
uniprot
Q9UE64
resolver
uniprot
Q9UM71
resolver
uniprot_entry
ABEC1_HUMAN
resolver
uniprot_sec
Q9UE64
resolver
uniprot_sec
Q9UM71
resolver
amino_acid_sequence
MTSEKGPSTGDPTLRRRIEPWEFDVFYDPRELRKEACLLYEIKWGMSRKIWRSSGKNTTNHVEVNFIKKFTSERDFHPSMSCSITWFLSWSPCWECSQAIREFLSRHPGVTLVIYVARLFWHMDQQNRQGLRDLVNSGVTIQIMRASEYYHCWRNFVNYPPGDEAHWPQYPPLWMMLYALELHCIILSLPPCLKISRRWQNHLTFFRLHLQNCHYQTIPPHILLATGLIHPSVAWR
uniprot
proteins
ec_number
3.5.4.-
uniprot
proteins
ec_number
3.5.4.36
uniprot
proteins
function
FUNCTION: Cytidine deaminase catalyzing the cytidine to uridine postranscriptional editing of a variety of mRNAs (PubMed:30844405). Form complexes with cofactors that confer differential editing activity and selectivity. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the apolipoprotein B mRNA (PubMed:24916387). Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA (PubMed:11727199). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (By similarity). {ECO:0000250|UniProtKB:P51908, ECO:0000269|PubMed:11727199, ECO:0000269|PubMed:24916387, ECO:0000269|PubMed:30844405}.
uniprot
proteins
mass_dalton
28192
uniprot
proteins
protein_family
Cytidine and deoxycytidylate deaminase family
uniprot
proteins
pubmed
11352648
uniprot
proteins
pubmed
11727199
uniprot
proteins
pubmed
22580899
uniprot
proteins
pubmed
24916387
uniprot
proteins
pubmed
30844405
uniprot
proteins
pubmed
8078915
uniprot
proteins
pubmed
8208612
uniprot
proteins
pubmed
8999813
uniprot
proteins
pubmed
9186903
uniprot
proteins
pubmed
9479499
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22580899}. Nucleus {ECO:0000269|PubMed:24916387}.
uniprot
proteins