Bclaf3
entrez
382252
canonical
uniprot
A2AG58
canonical
ensembl
ENSMUSG00000044150
resolver
ensp
ENSMUSP00000051031
resolver
ensp
ENSMUSP00000108083
resolver
ensp
ENSMUSP00000286562
resolver
ensp
ENSMUSP00000286563
resolver
ensp
ENSMUSP00000286567
resolver
ensp
ENSMUSP00000286572
resolver
ensp
ENSMUSP00000286576
resolver
genesymbol
Bclaf3
resolver
uniprot
A2AG56
resolver
uniprot
A2AG57
resolver
uniprot
Q3UM32
resolver
uniprot
Q8BRL2
resolver
uniprot_entry
BCLA3_MOUSE
resolver
uniprot_sec
A2AG56
resolver
uniprot_sec
A2AG57
resolver
uniprot_sec
Q3UM32
resolver
uniprot_sec
Q8BRL2
resolver
amino_acid_sequence
MARSRSRSPRWKQRSLSPQSRNFEYHEERHFHGHYDPEYRHDQQRPFTWRMDDEKHGQNKPRIPPRVNSYHRSYVNRSPSPNVKPVEKFDTYKPHQEYFPGRGDDDRRSQYMPTYTESAATYMEHERDCYIPTVQGRYTPDDHRGRGRGSGRGEKPPQMSLGKPPKMSLGKPPQMSLADSLRFKEKWHEDELRHQRVQEESYPQSPRRGSEDFGTRNPFQKRYPEDHDFRKYGYTSKRPTDAARYENRDPARIPKWKPEHSFLPFQEKKEEWSFGAQGHRYTEREYPERSSTTRVSYDYRHKHHKLSESEQDFPDGRFHKHLKEEDRKYSSIKAPANRELDCFSTTRGREIENEQINGPFYLYNKNSVSYNHTNIKDADLEPCNDKWKKKISKEDCRKENASFSKQFDTSPKPEEKCYSLIKKKPLSVKVDRNKTDTFRSTSRYSAERQISHDLVAIGKTSDNFHPVFQHLDSTQNPENKPTEEFAQEIITLIHKVKADSFVTPDITLNERFSRIKNRQDADFNQTKSNSDPEFHRRIDMSLDDFQNKYTMVYEPDKTLVKVIEPNDLRHDIERRRKERLQNEDENIFHMASPTERNHQSPSFSKVKTIRADGFQKPPHFIKSNFRKFIQKPYINYTMQRKDAIDQKIFRVEENHQNRRGSKGSFKNFLGGRFQPHYKSHLVQKSMYIQAKYQRLRFAGPRGFITNKFRNRFLRKKKEYPVLPRTNNLELLQVEPTLYEDLTEHLIFVRNWN
uniprot
proteins
function
FUNCTION: Component of the spliceosome complex, important for maintaining embryonic stem cell (ESC) fate. Interacts with long non-coding RNA Panct1, which facilitates BCLAF3 recruitment at sites of OCT-SOX motifs in nuclear foci and regulates alternative splicing of pluripotency genes in ESCs (PubMed:29241531, PubMed:37751355). May also be involved in the negative regulation of Wnt-driven stem cell-dependent epithelial renewal in the gastric mucosa (PubMed:33479180). {ECO:0000269|PubMed:29241531, ECO:0000269|PubMed:33479180, ECO:0000269|PubMed:37751355}.
uniprot
proteins
mass_dalton
90111
uniprot
proteins
protein_family
BCLAF1/THRAP3 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29241531
uniprot
proteins
pubmed
33479180
uniprot
proteins
pubmed
37751355
uniprot
proteins
sequence_length
752
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29241531, ECO:0000269|PubMed:37751355}. Nucleus speckle {ECO:0000269|PubMed:37751355}. Note=Colocalizes with Panct1 RNA to nuclear foci in the early G1 phase in ESCs. {ECO:0000269|PubMed:29241531}.
uniprot
proteins