Dcaf15
entrez
212123
canonical
uniprot
Q6PFH3
canonical
ensembl
ENSMUSG00000037103
resolver
ensp
ENSMUSP00000038568
resolver
ensp
ENSMUSP00000147690
resolver
genesymbol
Dcaf15
resolver
uniprot
Q3U305
resolver
uniprot
Q8BMB2
resolver
uniprot_entry
DCA15_MOUSE
resolver
uniprot_sec
Q3U305
resolver
uniprot_sec
Q8BMB2
resolver
amino_acid_sequence
MAPSSKSERNSGAGSAGGGPGGTGGKRAVGRRREHVLKQLERVKISGQLSPRLFRKLPPRVCVSLKNIVDEDFLYAGHIFLGFSKCGRYVLSYTSSSGDDDFSFYIYHLYWWEFNVHSKLKLVRQVRLFQDEEIYSDLYLTVCEWPSDASKVIVFGFNTRSANGMLMNMMMMSDENHRDIYISTVAVPPRGRCAACQDASRAHPGDPSAQCLRHGFMLHTKYQVVYPFPTFQPAFQLKKDQVVLLNTSYSLVACAVSVHSAGDSSFCQILYDHTALPPAPPSSPGPWSPEAAPAFPSLGVEVVPAQPSGAPEPSPAIAKAKEFVADIFRRAKEAKGSPLEETRLPSSLGPSSSRCRPSLEPQAPSGEVVPRDSPPAAETTAPEPGYINYTKLHYVLQSGEGTEPEDEFEDDKISLPFVVTDLRGRNLRPMRERTDMQGQYLTVEQLTLDFEYVINEVIRHDATWGHQFCSFSDYDIVILEVCPETNQVLINIGLLLLAFPAPTEEGQLRPKTYHTSLKVAWDLNTGIFETVSVGDLTEVKGQTSGSVWSSYRKSCVDMVMKWLVPESSGRYVNRMTNEALHKGCSLKVLADSERYTWIVL
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins. The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3. May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells. {ECO:0000250|UniProtKB:Q66K64}.
uniprot
proteins
mass_dalton
66643
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q66K64}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
600
uniprot
proteins