Bmp10
entrez
500245
canonical
uniprot
Q4AEG6
canonical
ensembl
ENSRNOG00000009316
resolver
ensembl
ENSRNOG00055012919
resolver
ensembl
ENSRNOG00060030679
resolver
ensembl
ENSRNOG00065014959
resolver
ensp
ENSRNOP00000012365
resolver
ensp
ENSRNOP00055017968
resolver
ensp
ENSRNOP00060044316
resolver
ensp
ENSRNOP00065019326
resolver
enst
ENSRNOT00000012365
resolver
enst
ENSRNOT00055022127
resolver
enst
ENSRNOT00060053300
resolver
enst
ENSRNOT00065024741
resolver
genesymbol
Bmp10
resolver
uniprot
A0A0H2UHH4
resolver
uniprot_entry
A0A0H2UHH4_RAT
resolver
uniprot_entry
BMP10_RAT
resolver
amino_acid_sequence
MGSLVLPLSAVFCLVARLASGSPIMGLEQSPLEEDMPFFDDIFTEQDGIDFNTLLQSMKDEFLKTLNLSDIPPQDTGRVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSFNGIRKYPLLFNVSIPHHEEVVMAELRLYTLVQRDRLMYDGVDRKIIIFEVLESADGSEDERSMLVLVSTEIYGTNSEWETFDITDATRRWQKSGPSTHQLEIHIESRQNQAEDTGRGQLEIDMSAQNKHDPLLVVFSDDQSGDKEQKEELNELISHEQDLDLGTDGFFGGPDEEALLQMRSNMIDDSTARIRRNAKGNYCKKTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLDPISILYLDKGVVTYKFKYEGMAVSECGCR
uniprot
proteins
function
FUNCTION: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. {ECO:0000250|UniProtKB:O95393}.
uniprot
proteins
mass_dalton
47767
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
15978772
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P12643}.
uniprot
proteins