SLC7A13
entrez
157724
canonical
uniprot
Q8TCU3
canonical
ensembl
ENSG00000164893
resolver
ensp
ENSP00000297524
resolver
genesymbol
SLC7A13
resolver
genesymbol_syn
AGT1
resolver
genesymbol_syn
XAT2
resolver
hgnc
HGNC:23092
resolver
uniprot
Q05C37
resolver
uniprot
Q08AH9
resolver
uniprot
Q96N84
resolver
uniprot_entry
S7A13_HUMAN
resolver
uniprot_sec
Q05C37
resolver
uniprot_sec
Q08AH9
resolver
uniprot_sec
Q96N84
resolver
amino_acid_sequence
MDRGEKIQLKRVFGYWWGTSFLLINIIGAGIFVSPKGVLAYSCMNVGVSLCVWAGCAILAMTSTLCSAEISISFPCSGAQYYFLKRYFGSTVAFLNLWTSLFLGSGVVAGQALLLAEYSIQPFFPSCSVPKLPKKCLALAMLWIVGILTSRGVKEVTWLQIASSVLKVSILSFISLTGVVFLIRGKKENVERFQNAFDAELPDISHLIQAIFQGYFAYSGGACFTLIAGELKKPRTTIPKCIFTALPLVTVVYLLVNISYLTVLTPREILSSDAVAITWADRAFPSLAWIMPFAISTSLFSNLLISIFKSSRPIYLASQEGQLPLLFNTLNSHSSPFTAVLLLVTLGSLAIILTSLIDLINYIFFTGSLWSILLMIGILRRRYQEPNLSIPYKVFLSFPLATIVIDVGLVVIPLVKSPNVHYVYVLLLVLSGLLFYIPLIHFKIRLAWFEKMTCYLQLLFNICLPDVSEE
uniprot
proteins
function
FUNCTION: Associates with SLC3A1/rBAT to form a functional heterodimeric complex that transports anionic and neutral amino acids across the apical plasma membrane of renal epithelium. Preferentially mediates exchange transport, but can also operate via facilitated diffusion. May act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate. {ECO:0000250|UniProtKB:Q91WN3}.
uniprot
proteins
mass_dalton
52114
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
pubmed
11943479
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q91WN3}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 46..66; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 129..149; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 288..308; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 337..357; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 359..379; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 394..414; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 422..442; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins