O35116
uniprot
O35116
canonical
amino_acid_sequence
FPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGEANGKDAESSGCWGKKKKKKKSQDQWDGVG
uniprot
proteins
function
FUNCTION: Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of canonical Wnt signaling (By similarity). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (PubMed:20623542). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33 (By similarity). {ECO:0000250|UniProtKB:O35927, ECO:0000250|UniProtKB:Q9UQB3, ECO:0000269|PubMed:20623542, ECO:0000269|PubMed:25807484}.
uniprot
proteins
mass_dalton
28928
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000250}.; PTM: Phosphorylated by CDK5 (PubMed:17009320). Phosphorylated by GSK3B (By similarity). {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:17009320}.
uniprot
proteins
protein_family
Beta-catenin family
uniprot
proteins
pubmed
10896674
uniprot
proteins
pubmed
17009320
uniprot
proteins
pubmed
20623542
uniprot
proteins
pubmed
25807484
uniprot
proteins
sequence_length
264
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O35927}. Cell junction, adherens junction {ECO:0000250|UniProtKB:O35927}. Cell projection, dendrite {ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:20623542}. Perikaryon {ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:20623542}.
uniprot
proteins