Flrt3
entrez
366205
canonical
uniprot
B1H234
canonical
ensembl
ENSRNOG00000004874
resolver
ensembl
ENSRNOG00055023471
resolver
ensembl
ENSRNOG00060002232
resolver
ensembl
ENSRNOG00065029134
resolver
ensp
ENSRNOP00000006454
resolver
ensp
ENSRNOP00000089101
resolver
ensp
ENSRNOP00055032780
resolver
ensp
ENSRNOP00055032783
resolver
ensp
ENSRNOP00060002380
resolver
ensp
ENSRNOP00060002382
resolver
ensp
ENSRNOP00065041343
resolver
ensp
ENSRNOP00065041353
resolver
enst
ENSRNOT00000006454
resolver
enst
ENSRNOT00000115709
resolver
enst
ENSRNOT00055040341
resolver
enst
ENSRNOT00055040344
resolver
enst
ENSRNOT00060003484
resolver
enst
ENSRNOT00060003486
resolver
enst
ENSRNOT00065050321
resolver
enst
ENSRNOT00065050331
resolver
genesymbol
Flrt3
resolver
uniprot
A0A0H2UHD5
resolver
uniprot_entry
A0A0H2UHD5_RAT
resolver
uniprot_entry
FLRT3_RAT
resolver
amino_acid_sequence
MISPAWSLFLIGTKIGLFFQVAPLSVMAKSCPSVCRCDAGFIYCNDRSLTSIPVGIPEDATTLYLQNNQINNVGIPSDLKNLLKVQRIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPGGLPRTIEELRLDDNRISTISSPSLHGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTSLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLSAELFDCKDSGIVSTVQITTAIPNTAYPAQGQWPAPVTKQPDIKNPKLTKDQRTTGSPSRKTILITVKSVTPDTIHISWRLALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVTALEPESPYRVCMVPMETSNLYLFDETPVCIETQTAPLRMYNPTTTLNREQEKEPYKNPNLPLAAIIGGAVALVSIALLALVCWYVHRNGSLFSRNCAYSKGRRRKDDYAEAGTKKDNSILEIRETSFQMLPISNEPISKEEFVIHTIFPPNGMNLYKNNLSESSSNRSYRDSGIPDLDHSHS
uniprot
proteins
function
FUNCTION: Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (By similarity). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (By similarity). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length (PubMed:15485775). Plays a role in the regulation of the density of glutamaergic synapses (PubMed:22405201). Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity). {ECO:0000250|UniProtKB:Q8BGT1, ECO:0000250|UniProtKB:Q9NZU0, ECO:0000269|PubMed:15485775, ECO:0000269|PubMed:22405201}.
uniprot
proteins
mass_dalton
72911
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q8BGT1}.; PTM: Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease. {ECO:0000250|UniProtKB:Q8BGT1}.
uniprot
proteins
pubmed
14706654
uniprot
proteins
pubmed
15485775
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22405201
uniprot
proteins
sequence_length
649
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15485775, ECO:0000269|PubMed:22405201}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8BGT1}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q8BGT1}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8BGT1}. Synapse, synaptosome {ECO:0000269|PubMed:22405201}. Postsynaptic density {ECO:0000269|PubMed:22405201}. Cell projection, dendrite {ECO:0000269|PubMed:22405201}. Synapse {ECO:0000269|PubMed:22405201}. Presynaptic cell membrane {ECO:0000269|PubMed:15485775}. Cell projection, axon {ECO:0000269|PubMed:15485775}. Cell projection, growth cone membrane {ECO:0000269|PubMed:15485775}. Cytoplasmic vesicle {ECO:0000269|PubMed:15485775}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BGT1}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q8BGT1}. Secreted {ECO:0000250|UniProtKB:Q8BGT1}. Note=Detected on dendritic punctae that colocalize in part with glutamaergic synapses, but not with GABAergic synapses (PubMed:22405201). Proteolytic cleavage in the juxtamembrane region gives rise to a shedded ectodomain (By similarity). {ECO:0000250|UniProtKB:Q8BGT1, ECO:0000269|PubMed:15485775, ECO:0000269|PubMed:22405201}.
uniprot
proteins
transmembrane_region
TRANSMEM 529..549; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins