Nfatc2ip
entrez
308983
canonical
uniprot
Q6AYG7
canonical
ensembl
ENSRNOG00000057384
resolver
ensp
ENSRNOP00000111459
resolver
enst
ENSRNOT00000121352
resolver
genesymbol
Nfatc2ip
resolver
uniprot_entry
NF2IP_RAT
resolver
amino_acid_sequence
MAEPLRRRGPRSRGGRASRGARRARAARGRCPRAPRSPTRLIPDTVLVDLVSDSDEEVLEVVADPGEVPVARLPAPAAPEQDSDSDSEGAAEGPAGAPRTLVRRRRRLLDPGEAPVVPVYSGKVQSSLNLIPDNSSLLKLCPSEPEDEADLTDSGSPPSEDALPPGSPWKKKLRKKHEKEEKKMEEFPDQDISPLPQPSSRNKSRKHTEALQKLREVNKRLQDLRSCLSPKQHQSPALQNTDDEVVLVEGSVLPQNPRLFTLKIRCRADLVRLPVKTSEPLQNVVDHMASHLGVSPNRILLLFGETELSPTATPRTLKLGVADIIDCVVLASSSEDTETSQELRLRVQGKEKHQMLEISLSPDSPLKVLMSHYEEAMGLSGHKLSFFFDGTKLSGKELPTDLGLESGDLIEVWG
uniprot
proteins
function
FUNCTION: In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
45430
uniprot
proteins
post_translational_modification
PTM: Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
414
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus. {ECO:0000250}.
uniprot
proteins