FGG
entrez
2266
canonical
uniprot
P02679
canonical
ensembl
ENSG00000171557
resolver
ensp
ENSP00000336829
resolver
ensp
ENSP00000384860
resolver
genesymbol
FGG
resolver
hgnc
HGNC:3694
resolver
uniprot
A0A140VJJ6
resolver
uniprot
A8K057
resolver
uniprot
P04469
resolver
uniprot
P04470
resolver
uniprot
Q53Y18
resolver
uniprot
Q96A14
resolver
uniprot
Q96KJ3
resolver
uniprot
Q9UC62
resolver
uniprot
Q9UC63
resolver
uniprot
Q9UCF3
resolver
uniprot_entry
A0A140VJJ6_HUMAN
resolver
uniprot_entry
FIBG_HUMAN
resolver
uniprot_sec
A8K057
resolver
uniprot_sec
P04469
resolver
uniprot_sec
P04470
resolver
uniprot_sec
Q53Y18
resolver
uniprot_sec
Q96A14
resolver
uniprot_sec
Q96KJ3
resolver
uniprot_sec
Q9UC62
resolver
uniprot_sec
Q9UC63
resolver
uniprot_sec
Q9UCF3
resolver
amino_acid_sequence
MSWSLHPRNLILYFYALLFLSSTCVAYVATRDNCCILDERFGSYCPTTCGIADFLSTYQTKVDKDLQSLEDILHQVENKTSEVKQLIKAIQLTYNPDESSKPNMIDAATLKSRKMLEEIMKYEASILTHDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLTIGEGQQHHLGGAKQVRPEHPAETEYDSLYPEDDL
uniprot
proteins
disease_involvement
DISEASE: Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. {ECO:0000269|PubMed:25427968}. Note=The disease is caused by variants affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.; DISEASE: Dysfibrinogenemia, congenital (DYSFIBRIN) [MIM:616004]: A disorder characterized by qualitative abnormalities (dysfibrinogenemia) of the circulating fibrinogen. Affected individuals are frequently asymptomatic, but some patients have bleeding diathesis, thromboembolic complications, or both. In some cases, dysfibrinogenemia is associated with low circulating fibrinogen levels (hypodysfibrinogenemia). {ECO:0000269|PubMed:15632207, ECO:0000269|PubMed:2257302, ECO:0000269|PubMed:2976995, ECO:0000269|PubMed:3708159}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
uniprot
proteins
mass_dalton
51512
uniprot
proteins
post_translational_modification
PTM: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. {ECO:0000269|PubMed:2143188}.; PTM: Sulfation of C-terminal tyrosines increases affinity for thrombin. {ECO:0000269|PubMed:11307817, ECO:0000269|PubMed:1892842}.
uniprot
proteins
pubmed
10074346
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
11307817
uniprot
proteins
pubmed
11435303
uniprot
proteins
pubmed
11986213
uniprot
proteins
pubmed
1421174
uniprot
proteins
pubmed
1455400
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14760718
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15632207
uniprot
proteins
pubmed
16263699
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
1685103
uniprot
proteins
pubmed
1733971
uniprot
proteins
pubmed
18780401
uniprot
proteins
pubmed
1892842
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19296670
uniprot
proteins
pubmed
2071611
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2143188
uniprot
proteins
pubmed
2257302
uniprot
proteins
pubmed
2328317
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2496144
uniprot
proteins
pubmed
25427968
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
2738036
uniprot
proteins
pubmed
2819242
uniprot
proteins
pubmed
2971042
uniprot
proteins
pubmed
2971046
uniprot
proteins
pubmed
2976995
uniprot
proteins
pubmed
2990550
uniprot
proteins
pubmed
3160702
uniprot
proteins
pubmed
3337908
uniprot
proteins
pubmed
3563970
uniprot
proteins
pubmed
3708159
uniprot
proteins
pubmed
6092346
uniprot
proteins
pubmed
6325435
uniprot
proteins
pubmed
6326808
uniprot
proteins
pubmed
6383194
uniprot
proteins
pubmed
6451630
uniprot
proteins
pubmed
6575689
uniprot
proteins
pubmed
6592597
uniprot
proteins
pubmed
6688357
uniprot
proteins
pubmed
6689067
uniprot
proteins
pubmed
6860649
uniprot
proteins
pubmed
6933547
uniprot
proteins
pubmed
7306501
uniprot
proteins
pubmed
7654933
uniprot
proteins
pubmed
7841300
uniprot
proteins
pubmed
8080993
uniprot
proteins
pubmed
8400260
uniprot
proteins
pubmed
8470043
uniprot
proteins
pubmed
8509453
uniprot
proteins
pubmed
9016719
uniprot
proteins
pubmed
9207064
uniprot
proteins
pubmed
9333233
uniprot
proteins
pubmed
936108
uniprot
proteins
pubmed
9628725
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10074346, ECO:0000269|PubMed:19296670, ECO:0000269|PubMed:9628725}.
uniprot
proteins