Tnk2
entrez
51789
canonical
uniprot
O54967
canonical
ensembl
ENSMUSG00000022791
resolver
ensp
ENSMUSP00000110773
resolver
ensp
ENSMUSP00000110776
resolver
ensp
ENSMUSP00000110777
resolver
ensp
ENSMUSP00000110778
resolver
ensp
ENSMUSP00000158905
resolver
ensp
ENSMUSP00000159023
resolver
ensp
ENSMUSP00000159113
resolver
ensp
ENSMUSP00000178684
resolver
ensp
ENSMUSP00000178685
resolver
ensp
ENSMUSP00000178686
resolver
enst
ENSMUST00000115120
resolver
enst
ENSMUST00000115123
resolver
enst
ENSMUST00000115124
resolver
enst
ENSMUST00000115125
resolver
enst
ENSMUST00000238806
resolver
enst
ENSMUST00000238856
resolver
genesymbol
Tnk2
resolver
genesymbol_syn
Ack1
resolver
uniprot
A0A0R4J1L0
resolver
uniprot
A0A5F8MPC4
resolver
uniprot
A0A5F8MPM0
resolver
uniprot
D3Z3U6
resolver
uniprot
D3Z3U7
resolver
uniprot
G3X9X7
resolver
uniprot
Q0Z844
resolver
uniprot
Q8C2U0
resolver
uniprot
Q8K0K4
resolver
uniprot_entry
A0A0R4J1L0_MOUSE
resolver
uniprot_entry
A0A5F8MPC4_MOUSE
resolver
uniprot_entry
A0A5F8MPM0_MOUSE
resolver
uniprot_entry
ACK1_MOUSE
resolver
uniprot_entry
D3Z3U6_MOUSE
resolver
uniprot_entry
D3Z3U7_MOUSE
resolver
uniprot_entry
G3X9X7_MOUSE
resolver
uniprot_sec
Q0Z844
resolver
uniprot_sec
Q8C2U0
resolver
uniprot_sec
Q8K0K4
resolver
amino_acid_sequence
MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKAMCKRKSWMSKVFSGKRLEAEFPSQHSQSTFRKPSPTPGSLPGEGTLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPAGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTLPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMAYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPTQHLGRVKREPPPRPPQPAIFTQKTTYDPVSEDPDPLSSDFKRLGLRKPALPRGLWLAKPSARVPGTKADRSSGGEVTLIDFGEEPVVPTPRPCAPSLAQLAMDACSLLDKTPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEVCSINSTLVGAGLPAGPSQGETNYAFVPEQAQMPPALEDNLFLPPQGGGKPPSSVQTAEIFQALQQECMRQLQVPTGQLTPSPTPGGDDKPQVPPRVPIPPRPTRPRVELSPAPSGEEETSRWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPHRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGRKVSSTHYYLLPERPPYLERYQRFLREAQSPEEPAALPVPPLLPPPSTPAPAAPTATVRPMPQAAPDPKANFSTNNSNPGARPPSLRAAARLPQRGCPGDGQEAARPADKVQMLQAMVHGVTTEECQAALQSHSWSVQRAAQYLKVEQLFGLGLRPRVECHKVLEMFDWNLEQAGCHLLGSCGPAHHKR
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. {ECO:0000269|PubMed:17182860, ECO:0000269|PubMed:20333297}.
uniprot
proteins
mass_dalton
116975
uniprot
proteins
mutagenesis
MUTAGEN 158; /note="K->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:16777958"; MUTAGEN 424; /note="W->K: Increase in autophosphorylation activity."; /evidence="ECO:0000269|PubMed:16777958"; MUTAGEN 464; /note="H->D: Loss of CDC42-binding and impairment of autophosphorylation."; /evidence="ECO:0000269|PubMed:16777958"; MUTAGEN 650; /note="Y->A: Loss of interaction with NEDD4 and drastic reduction in its ubiquitination."; /evidence="ECO:0000269|PubMed:17182860
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation regulates kinase activity. Phosphorylation on Tyr-533 is required for interaction with SRC and is observed during association with clathrin-coated pits (By similarity). {ECO:0000250}.; PTM: Polyubiquitinated by NEDD4 and NEDD4L. Degradation can be induced by EGF and is lysosome-dependent. {ECO:0000269|PubMed:20086093}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16052498
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16750431
uniprot
proteins
pubmed
16777958
uniprot
proteins
pubmed
17182860
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18477472
uniprot
proteins
pubmed
20086093
uniprot
proteins
pubmed
20333297
uniprot
proteins
pubmed
21169560
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
25223282
uniprot
proteins
sequence_length
1055
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16777958, ECO:0000269|PubMed:20333297}. Nucleus {ECO:0000269|PubMed:20333297}. Endosome {ECO:0000269|PubMed:17182860}. Cell junction, adherens junction {ECO:0000269|PubMed:18477472}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:Q07912}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q07912}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:21169560}. Cytoplasm, cytosol {ECO:0000269|PubMed:25223282}. Note=The Tyr-284 phosphorylated form is found both in the membrane and nucleus (PubMed:20333297). Co-localizes with EGFR on endosomes (PubMed:17182860). Nuclear translocation is CDC42-dependent (PubMed:21169560). Detected in long filamentous cytosolic structures where it co-localizes with CTPS1 (PubMed:25223282). {ECO:0000269|PubMed:17182860, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:21169560, ECO:0000269|PubMed:25223282}.
uniprot
proteins