O09046
uniprot
O09046
canonical
amino_acid_sequence
MAGLALRLVLAATLLGLAGSLDWKAASSLNPIEKCMEDHDYEQLLKVVTLGLNRTSKPQKVVVVGAGVAGLVAAKMLSDAGHKVTILEADNRIGGRIFTFRDEKTGWIGELGAMRMPSSHRILHKLCRTLGLNLTQFTQYDENTWTEVHNVKLRNYVVEKMPEKLGYNLNNRERGHSPEDIYQMALNKAFKDLKALGCKKAMNKFNKHTLLEYLLEEGNLSRPAVQLLGDVMSEEGFFYLSFAEALRAHACLSDRLRYSRIVGGWDLLPRALLSSLSGALLLNAPVVSITQGRNDVRVHIATSLHSEKTLTADVVLLTASGPALQRITFSPPLTRKRQEALRALHYVAASKVFLSFRRPFWHEEHIEGGHSNTDRPSRLIFYPARGEGSLLLASYTWSDAAAPFAGLSTDQTLRLVLQDVAALHGPVVFRLWDGRGVVKRWAEDPHSQGGFVVQPPLYGREAEDYDWSAPFGRIYFAGEHTALPHGWVETAVKSGLRAAVRINNNYGYGEVDPQMMEHAYAEANYLDQYPEGERPEEQQAREEVSPDEQEPSHKHLLVETSPEGQQHAFVEAIPELQGHVFVETVPQEKGHAHQNIYPSEHVQVHGEVIPEWHGHGGSGTPQMHRVGDHS
uniprot
proteins
ec_number
1.4.3.2
uniprot
proteins
ec_number
1.4.3.25
uniprot
proteins
function
FUNCTION: Secreted L-amino-acid oxidase that acts as a key immunoregulator (PubMed:32818467). Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively (PubMed:15383589). Also has weak L-arginine oxidase activity (By similarity). Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR (PubMed:21469114, PubMed:28405502, PubMed:32818467). IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer (By similarity). AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Also has an immunoregulatory function in some immune cell, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4(+) T-cells into FOXP3(+) regulatory T-cells (Treg) and regulates the development and function of B-cells (PubMed:25778793, PubMed:29288206). Also regulates M2 macrophage polarization by inhibiting T-cell activation (PubMed:26599209). Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4(+) and H2O2 (By similarity). {ECO:0000250|UniProtKB:Q96RQ9, ECO:0000269|PubMed:15383589, ECO:0000269|PubMed:21469114, ECO:0000269|PubMed:25778793, ECO:0000269|PubMed:26599209, ECO:0000269|PubMed:28405502, ECO:0000269|PubMed:29288206, ECO:0000269|PubMed:32818467}.
uniprot
proteins
mass_dalton
70191
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-tryptophan degradation via pyruvate pathway. {ECO:0000250|UniProtKB:Q96RQ9}.
uniprot
proteins
protein_family
FIG1 subfamily
uniprot
proteins
protein_family
Flavin monoamine oxidase family
uniprot
proteins
pubmed
15383589
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16029492
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21469114
uniprot
proteins
pubmed
25778793
uniprot
proteins
pubmed
26599209
uniprot
proteins
pubmed
28405502
uniprot
proteins
pubmed
29288206
uniprot
proteins
pubmed
32818467
uniprot
proteins
pubmed
9122225
uniprot
proteins
pubmed
9798653
uniprot
proteins
sequence_length
630
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q96RQ9}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q96RQ9}. Note=Secreted at the immunological synapse. {ECO:0000250|UniProtKB:Q96RQ9}.; SUBCELLULAR LOCATION: [Isoform 1]: Lysosome {ECO:0000269|PubMed:15383589}.; SUBCELLULAR LOCATION: [Isoform 2]: Lysosome {ECO:0000269|PubMed:15383589}.
uniprot
proteins