TAF12
entrez
6883
canonical
uniprot
Q16514
canonical
ensembl
ENSG00000120656
resolver
ensp
ENSP00000263974
resolver
ensp
ENSP00000362930
resolver
ensp
ENSP00000508345
resolver
ensp
ENSP00000509370
resolver
enst
ENST00000495422
resolver
genesymbol
TAF12
resolver
genesymbol_syn
TAF15
resolver
genesymbol_syn
TAF2J
resolver
genesymbol_syn
TAFII20
resolver
hgnc
HGNC:11545
resolver
uniprot
A0A804HLG9
resolver
uniprot
D3DPM5
resolver
uniprot
Q15775
resolver
uniprot
Q5T077
resolver
uniprot_entry
A0A804HLG9_HUMAN
resolver
uniprot_entry
TAF12_HUMAN
resolver
uniprot_sec
D3DPM5
resolver
uniprot_sec
Q15775
resolver
uniprot_sec
Q5T077
resolver
amino_acid_sequence
MNQFGPSALINLSNFSSIKPEPASTPPQGSMANSTAVVKIPGTPGAGGRLSPENNQVLTKKKLQDLVREVDPNEQLDEDVEEMLLQIADDFIESVVTAACQLARHRKSSTLEVKDVQLHLERQWNMWIPGFGSEEIRPYKKACTTEAHKQRMALIRKTTKK
uniprot
proteins
function
FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:10373431, PubMed:7729427, PubMed:8598932, PubMed:8663456, PubMed:9674425, PubMed:9885574). {ECO:0000269|PubMed:10373431, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:7729427, ECO:0000269|PubMed:8598932, ECO:0000269|PubMed:8663456, ECO:0000269|PubMed:9674425, ECO:0000269|PubMed:9885574}.
uniprot
proteins
mass_dalton
17924
uniprot
proteins
mutagenesis
MUTAGEN 87..91; /note="IADDF->EADDK: Drastically reduces binding to TAF4."; /evidence="ECO:0000269|PubMed:10594036"; MUTAGEN 95..96; /note="VV->EK: Drastically reduces binding to TAF4."; /evidence="ECO:0000269|PubMed:10594036"; MUTAGEN 99..103; /note="ACQLA->RCQLR: Drastically reduces binding to TAF4."; /evidence="ECO:0000269|PubMed:10594036
uniprot
proteins
protein_family
TAF12 family
uniprot
proteins
pubmed
10373431
uniprot
proteins
pubmed
10594036
uniprot
proteins
pubmed
11564863
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15735663
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
33795473
uniprot
proteins
pubmed
7729427
uniprot
proteins
pubmed
8598932
uniprot
proteins
pubmed
8647459
uniprot
proteins
pubmed
8663456
uniprot
proteins
pubmed
9674425
uniprot
proteins
pubmed
9885574
uniprot
proteins
sequence_length
161
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9674425}.
uniprot
proteins