O88384
uniprot
O88384
canonical
amino_acid_sequence
MAASAASSEHFEKLHEIFRGLLEDLQGVPERLLGTAGTEEKKKLVRDFDENQQEANETLAEMEEELRYAPLTFRNPMMSKLRNYRKDLAKLHREVRSTPLTAAPGGRGDLKYGTYTLENEHLNRLQSQRALLLQGTESLNRATQSIERSHRIATETDQIGTEIIEELGEQRDQLERTKSRLVNTNENLSKSRKILRSMSRKVITNKLLLSVIILLELAILVGLVYYKFFRHH
uniprot
proteins
function
FUNCTION: SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (PubMed:11786915, PubMed:15363411). On late endosomes, regulates trafficking from late endosomes to the lysosome (By similarity). {ECO:0000250|UniProtKB:Q9UEU0, ECO:0000269|PubMed:11786915, ECO:0000269|PubMed:15363411}.
uniprot
proteins
mass_dalton
26713
uniprot
proteins
protein_family
VTI1 family
uniprot
proteins
pubmed
11786915
uniprot
proteins
pubmed
15363411
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9553086
uniprot
proteins
sequence_length
232
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:Q9UEU0}; Single-pass type IV membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q9UEU0}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9UEU0}. Lysosome membrane {ECO:0000250|UniProtKB:Q9UEU0}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q9UEU0}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9UEU0}; Single-pass type IV membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 209..229; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins