St3gal2
entrez
20444
canonical
uniprot
Q11204
canonical
ensembl
ENSMUSG00000031749
resolver
ensp
ENSMUSP00000034197
resolver
ensp
ENSMUSP00000179273
resolver
ensp
ENSMUSP00000179274
resolver
enst
ENSMUST00000034197
resolver
genesymbol
St3gal2
resolver
genesymbol_syn
Siat4b
resolver
genesymbol_syn
Siat5
resolver
uniprot
Q8BPL0
resolver
uniprot_entry
SIA4B_MOUSE
resolver
uniprot_sec
Q8BPL0
resolver
amino_acid_sequence
MKCSLRVWFLSMAFLLVFIMSLLFTYSHHSMATLPYLDSGALGGTHRVKLVPGYSGLQRLGKEGLLGRNCACSRCMGDASTSEWFDSHFDGNISPVWTRDNMNLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPQQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKALDLMWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYRGN
uniprot
proteins
ec_number
2.4.3.2
uniprot
proteins
ec_number
2.4.3.4
uniprot
proteins
function
FUNCTION: A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8144500, PubMed:9184827). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8144500, PubMed:9184827). Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (PubMed:22735313). Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (PubMed:32030804). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (By similarity). Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:8144500). {ECO:0000250|UniProtKB:Q16842, ECO:0000269|PubMed:22735313, ECO:0000269|PubMed:32030804, ECO:0000269|PubMed:8144500, ECO:0000269|PubMed:9184827}.
uniprot
proteins
mass_dalton
40130
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000305|PubMed:8144500}.; PATHWAY: Glycolipid biosynthesis. {ECO:0000305|PubMed:22735313, ECO:0000305|PubMed:8144500}.
uniprot
proteins
post_translational_modification
PTM: The soluble form derives from the membrane form by proteolytic processing.; PTM: N-glycosylated; necessary for proper exit from endoplasmic reticulum and trafficking to the Golgi apparatus. {ECO:0000250|UniProtKB:Q16842}.
uniprot
proteins
protein_family
Glycosyltransferase 29 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22735313
uniprot
proteins
pubmed
32030804
uniprot
proteins
pubmed
8144500
uniprot
proteins
pubmed
9184827
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q16842}; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form distributed along the Golgi cisternae, mainly in proximal compartments (By similarity). Secreted into the body fluid. {ECO:0000250|UniProtKB:Q16842}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins