Larp1
entrez
73158
canonical
uniprot
Q6ZQ58
canonical
ensembl
ENSMUSG00000037331
resolver
ensp
ENSMUSP00000136673
resolver
genesymbol
Larp1
resolver
genesymbol_syn
Kiaa0731
resolver
genesymbol_syn
Larp
resolver
uniprot
A2AFQ8
resolver
uniprot
J3QNB1
resolver
uniprot
Q7TSF7
resolver
uniprot_entry
LARP1_MOUSE
resolver
uniprot_sec
A2AFQ8
resolver
uniprot_sec
J3QNB1
resolver
uniprot_sec
Q7TSF7
resolver
amino_acid_sequence
MATQVEPLLPAGAPLLQAEEHGLARKKPAPDAQAESGPGDGGGEPDGGVRRPRPACARPGRDGAERESPRPPAAAEAPAGSDGEDGGRRDFVEAPPPKVNPWTKHAPPPAAVNGQPPPEPSAPAKVVRAAAPKPRKGSKVGDFGDAVNWPTPGEIAHKSVQPQSHKPQPARKLPPKKDMKEQEKGDGSDSKESPKTKSDESGEEKNGDEDCQRGGQKKKGSKHKWVPLQIDMKPEVPREKLASRPTRPQEPRHTPAVRGEMKGSEPATYMPVSVAPPTPAWQPETKVEPAWHDQDETSSVKSDGAGGARASFRGRGRGRGRGRGRGRGGTRTHFDYQFGYRKFDGTEGPRTHKYMNNITYYFDNVSSNEIYSMDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEMVEEKVRRREEPEKWPLPGPPIVDYSQTDFSQLLNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSESWIEVKKRPRPSPARPKKPEEPRFSHPTALPQQLPSQQLMSKDQDEQEELDFLFDEEMEQMDGRKNTFTAWSEEDSDYEIDDRDVNKILIVTQTPPYMRRHPGGDRTGNHTSRAKMSAELAKVINDGLFYYEQDLWTEKFEPEYSQIKQEVENFKKVNMISREQFDTLTPEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNARTPRTPRTPQLKDSSQTPRFYPVVKEGRTLDAKMPRKRKTRHSSNPPLESHVGWVMDSREHRPRTASISSSPSEGTPAVGSYGCTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFKDFQEETVKDYEAGQLYGLEKFWAFLKYSKAKNLDIDPKLQEYLGKFRRLEDFRVDPPMGEEGNHKRHPVVAGGSGEGRKRCPSQSSSRPATGISQPPTTPTGQATREDAKWTSQHSDTLTLRK
uniprot
proteins
function
FUNCTION: RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1. When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA. Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif. Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes. Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation. Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis. {ECO:0000250|UniProtKB:Q6PKG0}.
uniprot
proteins
mass_dalton
121125
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on multiple Ser and Thr residues in response to active mTORC1. Phosphorylation is important for interaction with RPTOR and the mTORC1 complex. Phosphorylation promotes dissociation from the 5'UTR of mRNA molecules with a 5'TOP motif. {ECO:0000250|UniProtKB:Q6PKG0}.
uniprot
proteins
protein_family
LARP family
uniprot
proteins
pubmed
10878606
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
1072
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10878606}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q6PKG0}. Note=Colocalizes with RPTOR and PABPC1 in cytoplasmic granules that resemble stress granules. {ECO:0000250|UniProtKB:Q6PKG0}.
uniprot
proteins