SLC25A47
entrez
283600
canonical
uniprot
Q6Q0C1
canonical
ensembl
ENSG00000140107
resolver
ensp
ENSP00000354886
resolver
ensp
ENSP00000451078
resolver
enst
ENST00000557052
resolver
genesymbol
SLC25A47
resolver
genesymbol_syn
C14orf68
resolver
genesymbol_syn
HDMCP
resolver
hgnc
HGNC:20115
resolver
uniprot
B2RP39
resolver
uniprot
G3V374
resolver
uniprot
Q68CL2
resolver
uniprot
Q6PZD8
resolver
uniprot
Q86U14
resolver
uniprot_entry
G3V374_HUMAN
resolver
uniprot_entry
S2547_HUMAN
resolver
uniprot_sec
B2RP39
resolver
uniprot_sec
Q68CL2
resolver
uniprot_sec
Q6PZD8
resolver
uniprot_sec
Q86U14
resolver
amino_acid_sequence
MDFVAGAIGGVCGVAVGYPLDTVKVRIQTEPKYTGIWHCVRDTYHRERVWGFYRGLSLPVCTVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLTSPTEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEGLCGLYKGSSALVLRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGVLVAGGCAGVLAWAVATPMDVIKSRLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCCRAFPVNMVVFVAYEAVLRLARGLLT
uniprot
proteins
function
FUNCTION: Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q6IS41, ECO:0000269|PubMed:36804859}.
uniprot
proteins
mass_dalton
33435
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="K->A: Impaired NAD(+) uptake."; /evidence="ECO:0000269|PubMed:36804859"; MUTAGEN 188; /note="R->A: Impaired NAD(+) uptake."; /evidence="ECO:0000269|PubMed:36804859"; MUTAGEN 284; /note="R->A: Impaired NAD(+) uptake."; /evidence="ECO:0000269|PubMed:36804859
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15221005
uniprot
proteins
pubmed
15322095
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
36804859
uniprot
proteins
sequence_length
308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:15322095}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q6IS41}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 3..23; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 49..69; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 98..116; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 273..293; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins