GGA3
entrez
23163
canonical
uniprot
Q9NZ52
canonical
ensembl
ENSG00000125447
resolver
ensp
ENSP00000438085
resolver
ensp
ENSP00000446421
resolver
ensp
ENSP00000462081
resolver
ensp
ENSP00000463288
resolver
genesymbol
GGA3
resolver
genesymbol_syn
KIAA0154
resolver
hgnc
HGNC:17079
resolver
uniprot
A8K6M0
resolver
uniprot
B7Z456
resolver
uniprot
B7Z7E2
resolver
uniprot
B7Z7M9
resolver
uniprot
J3KRN0
resolver
uniprot
Q15017
resolver
uniprot
Q6IS16
resolver
uniprot
Q9UJY3
resolver
uniprot_entry
A8K6M0_HUMAN
resolver
uniprot_entry
B7Z456_HUMAN
resolver
uniprot_entry
GGA3_HUMAN
resolver
uniprot_sec
B7Z7E2
resolver
uniprot_sec
B7Z7M9
resolver
uniprot_sec
J3KRN0
resolver
uniprot_sec
Q15017
resolver
uniprot_sec
Q6IS16
resolver
uniprot_sec
Q9UJY3
resolver
amino_acid_sequence
MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIAVRLLAHKIQSPQEWEALQALTVLEACMKNCGRRFHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLYSWTMALPEEAKIKDAYHMLKRQGIVQSDPPIPVDRTLIPSPPPRPKNPVFDDEEKSKLLAKLLKSKNPDDLQEANKLIKSMVKEDEARIQKVTKRLHTLEEVNNNVRLLSEMLLHYSQEDSSDGDRELMKELFDQCENKRRTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTIIEGQVINGEVATLTLPDSEGNSQCSNQGTLIDLAELDTTNSLSSVLAPAPTPPSSGIPILPPPPQASGPPRSRSSSQAEATLGPSSTSNALSWLDEELLCLGLADPAPNVPPKESAGNSQWHLLQREQSDLDFFSPRPGTAACGASDAPLLQPSAPSSSSSQAPLPPPFPAPVVPASVPAPSAGSSLFSTGVAPALAPKVEPAVPGHHGLALGNSALHHLDALDQLLEEAKVTSGLVKPTTSPLIPTTTPARPLLPFSTGPGSPLFQPLSFQSQGSPPKGPELSLASIHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPLKEKVRLRYKLTFALGEQLSTEVGEVDQFPPVEQWGNL
uniprot
proteins
function
FUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}.
uniprot
proteins
mass_dalton
78315
uniprot
proteins
mutagenesis
MUTAGEN 91; /note="N->A: No effect on regulation of BACE1 degradation."; /evidence="ECO:0000269|PubMed:20484053"; MUTAGEN 194; /note="N->A: Loss of interaction with ARF1 and Golgi localization."; /evidence="ECO:0000269|PubMed:11301005"; MUTAGEN 199; /note="S->P: Loss of interaction with ARF1 and Golgi localization."; /evidence="ECO:0000269|PubMed:11301005"; MUTAGEN 217; /note="T->P: Loss of interaction with ARF1 and Golgi localization."; /evidence="ECO:0000269|PubMed:11301005"; MUTAGEN 247; /note="L->P: Loss of UBC-binding and ubiquitination."; /evidence="ECO:0000269|PubMed:14660606"; MUTAGEN 258; /note="K->M: No effect. Confers an affinity to RABEP1 identical to GGA1; when associated with N-283."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 262; /note="L->S: Loss of UBC-binding and ubiquitination."; /evidence="ECO:0000269|PubMed:14660606"; MUTAGEN 276; /note="L->A: Loss of UBC-binding and ubiquitination. Abolishes binding to ubiquitin. Abolishes regulation of BACE1 degradation. No effect on interaction with NTRK1."; /evidence="ECO:0000269|PubMed:14660606, ECO:0000269|PubMed:15039775, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26446845"; MUTAGEN 276; /note="L->S: Loss of UBC-binding and ubiquitination."; /evidence="ECO:0000269|PubMed:14660606, ECO:0000269|PubMed:15039775"; MUTAGEN 280; /note="L->R: Loss of UBC-binding and ubiquitination."; /evidence="ECO:0000269|PubMed:14660606"; MUTAGEN 283; /note="S->N: Can bind RABEP1. Confers an affinity to RABEP1 identical to GGA1; when associated with M-258."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 284; /note="D->G: Loss of UBC-binding and ubiquitination."; /evidence="ECO:0000269|PubMed:14660606"; MUTAGEN 293; /note="Y->H: Loss of UBC-binding and ubiquitination."; /evidence="ECO:0000269|PubMed:14660606"; MUTAGEN 313; /note="D->A: Acts as a dominant negative. Prevents proteolytic cleavage by CASP3; when associated with A-328, A-333 and A-428."; /evidence="ECO:0000269|PubMed:17553422"; MUTAGEN 328; /note="D->A: Prevents proteolytic cleavage by CASP3; when associated with A-313, A-333 and A-428."; /evidence="ECO:0000269|PubMed:17553422"; MUTAGEN 333; /note="D->A: Prevents proteolytic cleavage by CASP3; when associated with A-313, A-328 and A-428."; /evidence="ECO:0000269|PubMed:17553422"; MUTAGEN 391..395; /note="DEELL->AAAAA: Increased binding to IGF2R."; /evidence="ECO:0000269|PubMed:12060753"; MUTAGEN 428; /note="D->A: Prevents proteolytic cleavage by CASP3; when associated with A-313, A-328 and A-333."; /evidence="ECO:0000269|PubMed:17553422
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CK2 and dephosphorylated by PP2A (By similarity). Phosphorylation of GGA3 allows the internal DXXLL motif to bind the VHS domain and to inhibit the recognition of cargo signals. {ECO:0000250}.; PTM: Ubiquitinated. {ECO:0000269|PubMed:14660606}.; PTM: Proteolytically cleaved during apoptosis by CASP3. {ECO:0000269|PubMed:17553422}.
uniprot
proteins
protein_family
GGA protein family
uniprot
proteins
pubmed
10747089
uniprot
proteins
pubmed
10749927
uniprot
proteins
pubmed
10814529
uniprot
proteins
pubmed
11301005
uniprot
proteins
pubmed
11387475
uniprot
proteins
pubmed
11950392
uniprot
proteins
pubmed
12032548
uniprot
proteins
pubmed
12060753
uniprot
proteins
pubmed
12213833
uniprot
proteins
pubmed
12505986
uniprot
proteins
pubmed
14567678
uniprot
proteins
pubmed
14638859
uniprot
proteins
pubmed
14660606
uniprot
proteins
pubmed
14665628
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15039775
uniprot
proteins
pubmed
15143060
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15615712
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17553422
uniprot
proteins
pubmed
20484053
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26446845
uniprot
proteins
pubmed
26477546
uniprot
proteins
pubmed
26811329
uniprot
proteins
pubmed
41348103
uniprot
proteins
pubmed
8590280
uniprot
proteins
sequence_length
723
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:10749927, ECO:0000269|PubMed:15039775}; Peripheral membrane protein {ECO:0000269|PubMed:10749927, ECO:0000269|PubMed:15039775}. Endosome membrane {ECO:0000269|PubMed:15039775}; Peripheral membrane protein {ECO:0000269|PubMed:15039775}. Early endosome membrane {ECO:0000269|PubMed:11950392}; Peripheral membrane protein {ECO:0000305}. Recycling endosome membrane {ECO:0000250|UniProtKB:A0A0G2JV04}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins