Kcnma1
entrez
83731
canonical
uniprot
Q62976
canonical
ensembl
ENSRNOG00000005985
resolver
ensp
ENSRNOP00000058962
resolver
ensp
ENSRNOP00000071652
resolver
ensp
ENSRNOP00000082424
resolver
ensp
ENSRNOP00000086150
resolver
enst
ENSRNOT00000065542
resolver
enst
ENSRNOT00000109865
resolver
genesymbol
Kcnma1
resolver
genesymbol_syn
Kcnma
resolver
uniprot
A0A8I5ZV96
resolver
uniprot
F1LNC7
resolver
uniprot
O08626
resolver
uniprot
O55180
resolver
uniprot
O88659
resolver
uniprot
Q7TMZ7
resolver
uniprot
Q7TMZ8
resolver
uniprot
Q7TQ55
resolver
uniprot
Q7TQ56
resolver
uniprot
Q7TQ57
resolver
uniprot
Q9WUI3
resolver
uniprot_entry
A0A8I5ZV96_RAT
resolver
uniprot_entry
F1LNC7_RAT
resolver
uniprot_entry
KCMA1_RAT
resolver
uniprot_sec
O08626
resolver
uniprot_sec
O55180
resolver
uniprot_sec
O88659
resolver
uniprot_sec
Q7TMZ7
resolver
uniprot_sec
Q7TMZ8
resolver
uniprot_sec
Q7TQ55
resolver
uniprot_sec
Q7TQ56
resolver
uniprot_sec
Q7TQ57
resolver
uniprot_sec
Q9WUI3
resolver
activity_regulation
ACTIVITY REGULATION: Ethanol and carbon monoxide-bound heme increase channel activation. {ECO:0000250|UniProtKB:Q12791}.; ACTIVITY REGULATION: [Isoform 2]: Heme inhibits channel activation. {ECO:0000269|PubMed:16166559}.
uniprot
proteins
amino_acid_sequence
MANGGGGGGGGSSGSSGGGGGGGGGETALRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEVVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRSRKRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDVTDPKRIKKCGCRRLEDEQPPTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELAKPGKLPLVSVNQEKNSGTHILMITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRPNRPKSRESRDKQKKEMVYR
uniprot
proteins
function
FUNCTION: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). {ECO:0000269|PubMed:10651830}.; FUNCTION: [Isoform 2]: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). {ECO:0000269|PubMed:16166559, ECO:0000269|PubMed:9403560}.
uniprot
proteins
mass_dalton
134374
uniprot
proteins
mutagenesis
MUTAGEN 685..686; /note="CH->SR: Loss of heme-induced channel inhibition as well as carbon monoxide-induced channel activation."; /evidence="ECO:0000269|PubMed:16166559
uniprot
proteins
post_translational_modification
PTM: Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity (By similarity). {ECO:0000250|UniProtKB:Q12791, ECO:0000305}.; PTM: Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network (By similarity). {ECO:0000250|UniProtKB:Q12791}.
uniprot
proteins
protein_family
Calcium-activated (TC 1.A.1.3) subfamily
uniprot
proteins
protein_family
KCa1.1/KCNMA1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10384881
uniprot
proteins
pubmed
10651830
uniprot
proteins
pubmed
11278440
uniprot
proteins
pubmed
16166559
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9403560
uniprot
proteins
sequence_length
1209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q12791}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 7]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11278440}; Multi-pass membrane protein {ECO:0000255}. Note=Has a dominant-negative effect on other isoforms, preventing their localization to the cell membrane. {ECO:0000269|PubMed:11278440}.
uniprot
proteins
transmembrane_region
TRANSMEM 88..108; /note="Helical; Name=Segment S0"; /evidence="ECO:0000255"; TRANSMEM 180..200; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 216..236; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 266..286; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 302..322; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 369..389; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins