DGKA
entrez
1606
canonical
uniprot
P23743
canonical
ensembl
ENSG00000065357
resolver
ensp
ENSP00000328405
resolver
ensp
ENSP00000377703
resolver
ensp
ENSP00000450359
resolver
ensp
ENSP00000549215
resolver
genesymbol
DGKA
resolver
genesymbol_syn
DAGK
resolver
genesymbol_syn
DAGK1
resolver
hgnc
HGNC:2849
resolver
uniprot
O75481
resolver
uniprot
O75482
resolver
uniprot
O75483
resolver
uniprot
O95217
resolver
uniprot
Q3ZE25
resolver
uniprot
Q8IZ56
resolver
uniprot
Q8N5Q2
resolver
uniprot_entry
DGKA_HUMAN
resolver
uniprot_sec
O75481
resolver
uniprot_sec
O75482
resolver
uniprot_sec
O75483
resolver
uniprot_sec
O95217
resolver
uniprot_sec
Q3ZE25
resolver
uniprot_sec
Q8IZ56
resolver
uniprot_sec
Q8N5Q2
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by calcium and phosphatidylserine. {ECO:0000269|PubMed:2175712}.
uniprot
proteins
amino_acid_sequence
MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIYLEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYTVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPMLMGPPPRSTNFFGFLS
uniprot
proteins
ec_number
2.7.1.107
uniprot
proteins
ec_number
2.7.1.93
uniprot
proteins
function
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15544348, PubMed:2175712). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:15544348, PubMed:2175712). Also plays an important role in the biosynthesis of complex lipids (Probable). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group (PubMed:15544348). Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol (PubMed:22627129). {ECO:0000269|PubMed:15544348, ECO:0000269|PubMed:2175712, ECO:0000269|PubMed:22627129, ECO:0000305}.
uniprot
proteins
mass_dalton
82630
uniprot
proteins
mutagenesis
MUTAGEN 134; /note="E->Q: Binds calcium but with decreased affinity."; /evidence="ECO:0000269|PubMed:30653270"; MUTAGEN 179; /note="E->Q: Loss of calcium-binding."; /evidence="ECO:0000269|PubMed:30653270
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000305|PubMed:15544348, ECO:0000305|PubMed:2175712, ECO:0000305|PubMed:22627129}.
uniprot
proteins
protein_family
Eukaryotic diacylglycerol kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15544348
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2175712
uniprot
proteins
pubmed
22627129
uniprot
proteins
pubmed
30653270
uniprot
proteins
pubmed
7959783
uniprot
proteins
pubmed
8180475
uniprot
proteins
sequence_length
735
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:2175712}.
uniprot
proteins