Kcne1
entrez
16509
canonical
uniprot
P23299
canonical
ensembl
ENSMUSG00000039639
resolver
ensp
ENSMUSP00000052248
resolver
ensp
ENSMUSP00000130866
resolver
enst
ENSMUST00000051705
resolver
enst
ENSMUST00000166707
resolver
genesymbol
Kcne1
resolver
uniprot
Q545H6
resolver
uniprot_entry
KCNE1_MOUSE
resolver
uniprot_entry
Q545H6_MOUSE
resolver
amino_acid_sequence
MSLPNSTTVLPFLARLWQETAEQGGNVSGLARKSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKAVFQARVLESFRACYVIENQAAVEQPATHLPELKPLS
uniprot
proteins
function
FUNCTION: Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE1 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit. Associates with KCNQ1/KVLQT1 alpha subunit to form the slowly activating delayed rectifier cardiac potassium (IKs) channel responsible for ventricular muscle action potential repolarization. The outward current reaches its steady state only after 50 seconds. Assembly with KCNH2/HERG alpha subunit Kv channel may regulate the rapidly activating component of the delayed rectifying potassium current (IKr) in heart. {ECO:0000250|UniProtKB:P15382}.
uniprot
proteins
mass_dalton
14578
uniprot
proteins
post_translational_modification
PTM: Phosphorylation inhibits the potassium current. {ECO:0000250}.; PTM: N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5. {ECO:0000250}.
uniprot
proteins
protein_family
Potassium channel KCNE family
uniprot
proteins
pubmed
1568475
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1655403
uniprot
proteins
pubmed
8900282
uniprot
proteins
sequence_length
129
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P15382, ECO:0000250|UniProtKB:P15383}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P15382}. Apical cell membrane {ECO:0000250|UniProtKB:P15383}. Membrane raft {ECO:0000250|UniProtKB:P15382}. Note=Colocalizes with KCNB1 at the plasma membrane (By similarity). Targets to the membrane raft when associated with KCNQ1 (By similarity). {ECO:0000250|UniProtKB:P15382, ECO:0000250|UniProtKB:P15383}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..66; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins