Lpcat2
entrez
270084
canonical
uniprot
Q8BYI6
canonical
ensembl
ENSMUSG00000033192
resolver
ensp
ENSMUSP00000049252
resolver
ensp
ENSMUSP00000147941
resolver
genesymbol
Lpcat2
resolver
genesymbol_syn
Aytl1
resolver
genesymbol_syn
Aytl1a
resolver
genesymbol_syn
Lpcat2a
resolver
uniprot
A3KBM0
resolver
uniprot
A9Q1G2
resolver
uniprot
A9Q1G3
resolver
uniprot_entry
PCAT2_MOUSE
resolver
uniprot_sec
A3KBM0
resolver
uniprot_sec
A9Q1G2
resolver
uniprot_sec
A9Q1G3
resolver
activity_regulation
ACTIVITY REGULATION: Acetyltransferase activity is increased following acute inflammatory stimulation by lipopolysaccharide (LPS). Acyltransferase activity is unchanged. {ECO:0000269|PubMed:17182612}.
uniprot
proteins
amino_acid_sequence
MNRCAEAAAVAATVPGSGVGDAGLRPPMVPRQASFFPPPVPNPFVQQTTISASRRLQMFLLGIILLPVRALLVGIILLLAWPFAVISTACCPEKLTHPISNWRRKITRPALTFLARAMFFSMGFTVTVKGKVASPLEAPIFVVAPHSTFFDGIACVVAGLPSLVSRNENAQTPLVGRLLRALQPVLVSRVDPDSRKNTINEIKKRATSGGEWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNKLDTVTWTWQGYTFLQLCVLTFCQLFTKVEIEFMPVQAPSEEEKNDPVLFASRIRNLMAEALEIPVTDHTYEDCRLMISAGQLTLPMEAGLVEFSKISRKLKLDWDGIRKHLDEYASIASSSKGGRIGIEEFAEYLKLPVSDVLRQLFALFDRNNDGSIDFREYVIGLAVLCNPANTEEIIQVAFKLFDVDEDGYITEEEFCTILQASLGVPDLNVSGLFREIAQRDSVSYEEFKSFALKHPEYAKIFTTYLDLQTCHVFSLPEEVQTAPSVASNKVSPESQEEGTSDKKVD
uniprot
proteins
ec_number
2.3.1.23
uniprot
proteins
ec_number
2.3.1.25
uniprot
proteins
ec_number
2.3.1.51
uniprot
proteins
ec_number
2.3.1.67
uniprot
proteins
function
FUNCTION: Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:18156367, PubMed:18285344). Activity is calcium-dependent (PubMed:17182612). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:17182612, PubMed:18156367). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:17182612, PubMed:18285344). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (PubMed:17182612). Under resting conditions, acyltransferase activity is preferred (PubMed:17182612). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (PubMed:17182612). Involved in the regulation of lipid droplet number and size (By similarity). {ECO:0000250|UniProtKB:Q8NF37, ECO:0000269|PubMed:17182612, ECO:0000269|PubMed:18156367, ECO:0000269|PubMed:18285344}.
uniprot
proteins
mass_dalton
60254
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; phospholipid metabolism.
uniprot
proteins
protein_family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17182612
uniprot
proteins
pubmed
18156367
uniprot
proteins
pubmed
18285344
uniprot
proteins
sequence_length
544
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17182612}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q7L5N7}. Golgi apparatus membrane {ECO:0000269|PubMed:17182612}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q7L5N7}. Cell membrane {ECO:0000305|PubMed:18156367}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q7L5N7}. Lipid droplet {ECO:0000250|UniProtKB:Q7L5N7}.
uniprot
proteins
transmembrane_region
TRANSMEM 59..79; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins