Akt3
entrez
23797
canonical
uniprot
Q9WUA6
canonical
ensembl
ENSMUSG00000019699
resolver
ensp
ENSMUSP00000106789
resolver
ensp
ENSMUSP00000106790
resolver
genesymbol
Akt3
resolver
uniprot
Q8C6X4
resolver
uniprot_entry
AKT3_MOUSE
resolver
uniprot_entry
Q8C6X4_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Two specific sites, one in the kinase domain (Thr-305) and the other in the C-terminal regulatory region (Ser-472), need to be phosphorylated for its full activation. IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDDDGMDGMDNERRPHFPQFSYSASGRE
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269|PubMed:15713641, ECO:0000269|PubMed:21159799, ECO:0000269|PubMed:21954288}.
uniprot
proteins
mass_dalton
55714
uniprot
proteins
mutagenesis
MUTAGEN 219; /note="D->V: Enhances kinase activity and causes low seizure threshold, sporadic tonic-clonic seizures, brain enlargement and ectopic neurons in the dentate hilus and molecular layer of the hippocampus."; /evidence="ECO:0000269|PubMed:21159799
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Thr-305 and Ser-472 is required for full activity. Phosphorylation of the activation loop at Thr-305 by PDPK1/PDK1 is a prerequisite for full activation (By similarity). Phosphorylation at Ser-472 by mTORC2 in response to growth factors plays a key role in AKT1 activation by facilitating subsequent phosphorylation of the activation loop by PDPK1/PDK1 (By similarity). {ECO:0000250|UniProtKB:Q60823, ECO:0000250|UniProtKB:Q9Y243}.; PTM: Ubiquitinated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome (By similarity). {ECO:0000250}.; PTM: O-GlcNAcylation at Thr-302 and Thr-309 inhibits activating phosphorylation at Thr-305 via disrupting the interaction between AKT and PDPK1/PDK1. {ECO:0000250|UniProtKB:P31749}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
RAC subfamily
uniprot
proteins
pubmed
10092583
uniprot
proteins
pubmed
11387345
uniprot
proteins
pubmed
15713641
uniprot
proteins
pubmed
18160256
uniprot
proteins
pubmed
18524868
uniprot
proteins
pubmed
21159799
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21620960
uniprot
proteins
pubmed
21954288
uniprot
proteins
pubmed
24156551
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.
uniprot
proteins