Orc2
entrez
18393
canonical
uniprot
Q60862
canonical
ensembl
ENSMUSG00000026037
resolver
ensp
ENSMUSP00000027198
resolver
ensp
ENSMUSP00000109964
resolver
ensp
ENSMUSP00000307190
resolver
ensp
ENSMUSP00000307192
resolver
ensp
ENSMUSP00000307198
resolver
enst
ENSMUST00000027198
resolver
enst
ENSMUST00000114325
resolver
genesymbol
Orc2
resolver
genesymbol_syn
Orc2l
resolver
uniprot
F6W7Z0
resolver
uniprot
Q543F8
resolver
uniprot
Q59IX1
resolver
uniprot_entry
F6W7Z0_MOUSE
resolver
uniprot_entry
ORC2_MOUSE
resolver
uniprot_entry
Q543F8_MOUSE
resolver
uniprot_entry
Q59IX1_MOUSE
resolver
amino_acid_sequence
MSTLQLKETKVPSVQFVGDDDVLSHILDREGGTKLKKEKAQLLVNPQKVIKKADCELEKSDLEVLEDQNYVKVLGRNIQESLGNGSAKDGRNKVYSFQQRKHPEEMTKLALELAKTSGKKDPLDSNDPEITKNIAQKSKGHSTSEKAPLVNNNKTEFLSTQPHNLRKRIIASRSHYDSESEYSASSSEDDEEATKDEEEDTNVARLSQKSQGQNRLLPAPVSKETLPKKKKRDKASDLVEEYFEAHSSSKVLTSDRTLQRLRRARVDQKTLHNLLRKFVPSFSAEIERLNQQHEKLFHKWMLQLHLGFNIVLYGLGSKRDLLEKFRTTMLQDSIHVVINGYFPGVSVKSILNSITEDVLSHVGTFQSVLDQRDWIINRFKEDSSLELFLLIHNLDSQMLRGDNSQQILGQLSSLHNVYLIASIDHLNAPLMWDHAKQSLYNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLIHVLRSLTPNARGIFRLLMKFQLDNQDSPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDSGILADFLEKEEEEA
uniprot
proteins
function
FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
65893
uniprot
proteins
protein_family
ORC2 family
uniprot
proteins
pubmed
12614612
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8808289
uniprot
proteins
sequence_length
576
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins