HEY2
entrez
23493
canonical
uniprot
Q9UBP5
canonical
ensembl
ENSG00000135547
resolver
ensp
ENSP00000357348
resolver
ensp
ENSP00000357349
resolver
enst
ENST00000368364
resolver
enst
ENST00000368365
resolver
genesymbol
HEY2
resolver
genesymbol_syn
BHLHB32
resolver
genesymbol_syn
CHF1
resolver
genesymbol_syn
GRL
resolver
genesymbol_syn
HERP
resolver
genesymbol_syn
HERP1
resolver
genesymbol_syn
HRT2
resolver
hgnc
HGNC:4881
resolver
uniprot
Q5TF93
resolver
uniprot_entry
HEY2_HUMAN
resolver
uniprot_entry
Q5TF93_HUMAN
resolver
amino_acid_sequence
MKRPCEETTSESDMDETIDVGSENNYSGQSTSSVIRLNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTCATQREAAAMTSSMAHHHHPLHPHHWAAAFHHLPAALLQPNGLHASESTPCRLSTTSEVPPAHGSALLTATFAHADSALRMPSTGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPPNAAAAVAAATAISPPLSVSATSSPQQTSSGTNNKPYRPWGTEVGAF
uniprot
proteins
function
FUNCTION: Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. {ECO:0000269|PubMed:10692439, ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:15485867, ECO:0000269|PubMed:16293227}.
uniprot
proteins
mass_dalton
35808
uniprot
proteins
mutagenesis
MUTAGEN 54; /note="G->P: Impairs transcriptional repression."; /evidence="ECO:0000269|PubMed:16293227
uniprot
proteins
protein_family
HEY family
uniprot
proteins
pubmed
10415358
uniprot
proteins
pubmed
10692439
uniprot
proteins
pubmed
10710309
uniprot
proteins
pubmed
11095750
uniprot
proteins
pubmed
11486044
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15485867
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16293227
uniprot
proteins
pubmed
16329098
uniprot
proteins
sequence_length
337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
uniprot
proteins