DYRK4
entrez
8798
canonical
uniprot
Q9NR20
canonical
ensembl
ENSG00000010219
resolver
ensp
ENSP00000439697
resolver
ensp
ENSP00000441755
resolver
enst
ENST00000543431
resolver
genesymbol
DYRK4
resolver
hgnc
HGNC:3095
resolver
uniprot
A0A0A0MTH5
resolver
uniprot
A8K8F7
resolver
uniprot
B4E1A4
resolver
uniprot
D3JEN2
resolver
uniprot
Q8NEF2
resolver
uniprot
Q92631
resolver
uniprot_entry
A0A0A0MTH5_HUMAN
resolver
uniprot_entry
B4E1A4_HUMAN
resolver
uniprot_entry
D3JEN2_HUMAN
resolver
uniprot_entry
DYRK4_HUMAN
resolver
uniprot_sec
A8K8F7
resolver
uniprot_sec
Q8NEF2
resolver
uniprot_sec
Q92631
resolver
amino_acid_sequence
MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV
uniprot
proteins
ec_number
2.7.12.1
uniprot
proteins
function
FUNCTION: Possible non-essential role in spermiogenesis. {ECO:0000250}.
uniprot
proteins
mass_dalton
59608
uniprot
proteins
mutagenesis
MUTAGEN 133; /note="K->R: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:17292540"; MUTAGEN 264; /note="Y->F: Abolishes kinase activity."; /evidence="ECO:0000269|PubMed:21127067
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation on Tyr-264 in the activation loop is required for kinase activity. {ECO:0000269|PubMed:21127067}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MNB/DYRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11062477
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17292540
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
21127067
uniprot
proteins
pubmed
9748265
uniprot
proteins
sequence_length
520
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:17292540}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:21127067}. Nucleus {ECO:0000269|PubMed:21127067}.
uniprot
proteins