TMED1
entrez
11018
canonical
uniprot
Q13445
canonical
ensembl
ENSG00000099203
resolver
ensp
ENSP00000214869
resolver
enst
ENST00000214869
resolver
genesymbol
TMED1
resolver
genesymbol_syn
IL1RL1L
resolver
genesymbol_syn
IL1RL1LG
resolver
hgnc
HGNC:17291
resolver
uniprot_entry
TMED1_HUMAN
resolver
amino_acid_sequence
MMAAGAALALALWLLMPPVEVGGAGPPPIQDGEFTFLLPAGRKQCFYQSAPANASLETEYQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEGNLERVNFWSAVNVAVLLLVAVLQVCTLKRFFQDKRPVPT
uniprot
proteins
function
FUNCTION: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1 (PubMed:23319592). Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). {ECO:0000269|PubMed:23319592, ECO:0000269|PubMed:32614325}.
uniprot
proteins
mass_dalton
25206
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="C->S: Significant loss of interaction with IL1RL1."; /evidence="ECO:0000269|PubMed:23319592"; MUTAGEN 106; /note="C->S: Significant loss of interaction with IL1RL1."; /evidence="ECO:0000269|PubMed:23319592
uniprot
proteins
protein_family
EMP24/GP25L family
uniprot
proteins
pubmed
10852829
uniprot
proteins
pubmed
12237308
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19892738
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23319592
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
32614325
uniprot
proteins
pubmed
8621446
uniprot
proteins
sequence_length
227
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:8621446}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308, ECO:0000269|PubMed:23319592}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 195..215; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins