Tmc4
entrez
353499
canonical
uniprot
Q7TQ65
canonical
ensembl
ENSMUSG00000019734
resolver
ensp
ENSMUSP00000043853
resolver
enst
ENSMUST00000038743
resolver
genesymbol
Tmc4
resolver
uniprot
F8VQ45
resolver
uniprot
Q7TMJ5
resolver
uniprot
Q7TN62
resolver
uniprot
Q8C7J5
resolver
uniprot
Q8CGE2
resolver
uniprot
Q8R1X9
resolver
uniprot_entry
F8VQ45_MOUSE
resolver
uniprot_entry
TMC4_MOUSE
resolver
uniprot_sec
Q7TMJ5
resolver
uniprot_sec
Q7TN62
resolver
uniprot_sec
Q8C7J5
resolver
uniprot_sec
Q8CGE2
resolver
uniprot_sec
Q8R1X9
resolver
amino_acid_sequence
MEAWGQSPACSSSRKARTGPSLASVLNDLPSAATLRYRGPGVLPWGTLDEDDDEGGRSLQAFAETAQMESHPSRELPWPMQARRAHRKSQATGQLASGSESRAAYWTRQLSRTKGKMKEGFQTIQPWAWTLKKIGGQFGAGTESYFSLLRFLLFLNLVASVIEICMKLIPTWLEGAPPGPPGPNISSPCGSYIPHTHGLVAFPTQLFNLLSGEGYLEWSPLFYGFYPPRSNLAITYLCSVFAISVIYLLCILRRSVSGLKETLLAESDILTSYSHRVFSAWNFGLCGDVHVRLRQRIILYELQVDLEEAVVRRRAAEQTLSQRAKVWSMRALLNVLVLALLGAAFYGIYWATEYTLTLQETPLVRQTPLFKLLVDYLPSIFISLFNFVLPPVFKFIASLEGYTQSRQIVLILLRTVFLRLASLVFLLVSLWSQITCGGNMEAEGCKACGYNYKEIPCWETRLGQEMYKLVLFDLLMGLLVTLLVQFPRKILCGLCPGALGRLSGTLEFQVPDEVLGLIYAQTVVWVGSFFCPLLPLINTAKFLILFCLKKITLFSIYSPASRTFRASTANFFFPLVLLVGLAISAVPVLYSIFLIPPSKLCGPFRGKLSIWAQIPEAIESLPQTAQNFLYFLGTQAFTVPLLILSSILMMYTVALANCYGRLISELKRQIETEVQNKVFLAQRAVALSSRNGTS
uniprot
proteins
function
FUNCTION: Voltage-gated chloride channel involved in high-concentration salt taste sensation (PubMed:34429071). Depolarization induced by high NaCl concentration may trigger the activation of TMC4-mediated chloride influx into taste bud cells, helping the return to resting potential (PubMed:34429071). Also allows permeation of organic anions including gluconate, but their current amplitudes at positive potentials are less than that of chloride (PubMed:34429071). Involved in pH and temperature-dependent modulation of salty taste (By similarity). {ECO:0000250|UniProtKB:Q7Z404, ECO:0000269|PubMed:34429071}.
uniprot
proteins
mass_dalton
77367
uniprot
proteins
protein_family
TMC family
uniprot
proteins
pubmed
12812529
uniprot
proteins
pubmed
12906855
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
34429071
uniprot
proteins
sequence_length
694
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 151..171; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 331..351; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 408..428; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 466..486; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 514..534; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 536..556; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 575..595; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 636..656; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins