Cd248
entrez
70445
canonical
uniprot
Q91V98
canonical
ensembl
ENSMUSG00000056481
resolver
ensp
ENSMUSP00000070847
resolver
enst
ENSMUST00000070630
resolver
genesymbol
Cd248
resolver
genesymbol_syn
Tem1
resolver
uniprot
Q3UMV6
resolver
uniprot
Q91ZV1
resolver
uniprot_entry
CD248_MOUSE
resolver
uniprot_sec
Q3UMV6
resolver
uniprot_sec
Q91ZV1
resolver
amino_acid_sequence
MLLRLLLAWVAAVPALGQVPWTPEPRAACGPSSCYALFPRRRTFLEAWRACRELGGNLATPRTPEEAQRVDSLVGVGPANGLLWIGLQRQARQCQPQRPLRGFIWTTGDQDTAFTNWAQPATEGPCPAQRCAALEASGEHRWLEGSCTLAVDGYLCQFGFEGACPALPLEVGQAGPAVYTTPFNLVSSEFEWLPFGSVAAVQCQAGRGASLLCVKQPSGGVGWSQTGPLCPGTGCGPDNGGCEHECVEEVDGAVSCRCSEGFRLAADGHSCEDPCAQAPCEQQCEPGGPQGYSCHCRLGFRPAEDDPHRCVDTDECQIAGVCQQMCVNYVGGFECYCSEGHELEADGISCSPAGAMGAQASQDLRDELLDDGEEGEDEEEPWEDFDGTWTEEQGILWLAPTHPPDFGLPYRPNFPQDGEPQRLHLEPTWPPPLSAPRGPYHSSVVSATRPMVISATRPTLPSAHKTSVISATRPPLSPVHPPAMAPATPPAVFSEHQIPKIKANYPDLPFGHKPGITSATHPARSPPYQPPIISTNYPQVFPPHQAPMSPDTHTITYLPPVPPHLDPGDTTSKAHQHPLLPDAPGIRTQAPQLSVSALQPPLPTNSRSSVHETPVPAANQPPAFPSSPLPPQRPTNQTSSISPTHSYSRAPLVPREGVPSPKSVPQLPSVPSTAAPTALAESGLAGQSQRDDRWLLVALLVPTCVFLVVLLALGIVYCTRCGSHAPNKRITDCYRWVTHAGNKSSTEPMPPRGSLTGVQTCRTSV
uniprot
proteins
function
FUNCTION: Cell surface glycoprotein involved in various biological processes including angiogenesis, immune response modulation, and tissue remodeling and repair (PubMed:11489895, PubMed:25243742, PubMed:38061240). Participates in pericyte proliferation through positive modulation of the PDGF receptor signaling pathway (PubMed:30986375). Acts as a scaffold for factor X, triggering allosteric changes and the spatial re-alignment of factor X with the TF-factor VIIa complex, thereby enhancing coagulation activation (PubMed:33830628). Modulates the insulin signaling pathway by interacting with insulin receptor/INSR and by diminishing its capacity to be autophosphorylated in response to insulin (PubMed:38061240). Also regulates LPS-induced inflammatory responses in macrophages by favoring production of proinflammatory cytokines (PubMed:33737161). {ECO:0000269|PubMed:11489895, ECO:0000269|PubMed:25243742, ECO:0000269|PubMed:30986375, ECO:0000269|PubMed:33737161, ECO:0000269|PubMed:33830628, ECO:0000269|PubMed:38061240}.
uniprot
proteins
mass_dalton
81813
uniprot
proteins
post_translational_modification
PTM: O-glycosylated by sialylated oligosaccharides. {ECO:0000250}.; PTM: May be N-glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
11489895
uniprot
proteins
pubmed
11559528
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25243742
uniprot
proteins
pubmed
30986375
uniprot
proteins
pubmed
33737161
uniprot
proteins
pubmed
33830628
uniprot
proteins
pubmed
38061240
uniprot
proteins
sequence_length
765
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 696..716; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins