SLC22A15
entrez
55356
canonical
uniprot
Q8IZD6
canonical
ensembl
ENSG00000163393
resolver
ensp
ENSP00000358514
resolver
ensp
ENSP00000358515
resolver
ensp
ENSP00000548009
resolver
ensp
ENSP00000671061
resolver
ensp
ENSP00000752607
resolver
ensp
ENSP00000781766
resolver
genesymbol
SLC22A15
resolver
genesymbol_syn
FLIPT1
resolver
hgnc
HGNC:20301
resolver
uniprot
A8MUR3
resolver
uniprot
B3KWH0
resolver
uniprot
Q6UXP5
resolver
uniprot
Q8TAL9
resolver
uniprot
Q9NSH5
resolver
uniprot_entry
B3KWH0_HUMAN
resolver
uniprot_entry
S22AF_HUMAN
resolver
uniprot_sec
A8MUR3
resolver
uniprot_sec
Q6UXP5
resolver
uniprot_sec
Q8TAL9
resolver
uniprot_sec
Q9NSH5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by gamma-aminobutyric acid and drugs including quinidine and levofloxacin. {ECO:0000269|PubMed:33124720}.
uniprot
proteins
amino_acid_sequence
MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQSHGNQSAGEDQAFGDWLLTANGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVYSYRRLGEEALSLQALDPQQCVDKESSLGSESEEEEEFYDADEETQMIK
uniprot
proteins
function
FUNCTION: Organic zwitterion/cation transporter with apparent specificity for amino acids and their derivatives. Has low affinity for its substrates and may regulate their flux across the plasma membrane at high substrate concentrations (PubMed:33124720). Bidirectionally transports carnitine and acetylcarnitine, possibly regulating their cytosolic abundance and further fatty acid catabolism via beta oxidation (PubMed:33124720). Displays high transport activity toward zwitterionic substrates such as glycine betaine and diet-derived ergothioneine and carnosine. Can transport cations having an indole skeleton such as thiamine with lower efficiency. Does not transport agmatine (PubMed:15028572, PubMed:33124720). The transport mechanism, symport with sodium or facilitated diffusion allosterically regulated by sodium, remains to be elucidated (Probable). {ECO:0000269|PubMed:15028572, ECO:0000269|PubMed:33124720, ECO:0000305|PubMed:33124720}.
uniprot
proteins
mass_dalton
60540
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:33124720}.
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
12372408
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15028572
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
33124720
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:33124720}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 111..131; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 165..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 226..246; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 303..323; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 338..358; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 368..388; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 401..420; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 433..453; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 462..482; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins