Adarb1
entrez
25367
canonical
uniprot
P51400
canonical
ensembl
ENSRNOG00000001227
resolver
ensp
ENSRNOP00000001642
resolver
ensp
ENSRNOP00000099902
resolver
enst
ENSRNOT00000001642
resolver
enst
ENSRNOT00000145951
resolver
genesymbol
Adarb1
resolver
genesymbol_syn
Red1
resolver
uniprot
A0ABK0KYI9
resolver
uniprot
G3V649
resolver
uniprot_entry
A0ABK0KYI9_RAT
resolver
uniprot_entry
G3V649_RAT
resolver
uniprot_entry
RED1_RAT
resolver
amino_acid_sequence
MDIEDEENMSSSSIDVKENRNLDNMPPKDSSTPGPGEGIPLSNGGGGSTSRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYMLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKSEPPFYVGSNGDDSFSSSGDVSLSASPVPASLTQPPLPIPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALATVFNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGKFSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYAQLELYLNNKEDQKKSIFQKSERGGFRLKDTVQFHLYISTSPCGDARIFSPHEPVLEGMAPDSHQLTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGALLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDTAIEVINATTGKDELGRPSRLCKHALYCRWMRVHGKVPPHLLRTKITKPTTYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSFTP
uniprot
proteins
ec_number
3.5.4.37
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently (By similarity). Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000250, ECO:0000269|PubMed:16472753, ECO:0000269|PubMed:20501795, ECO:0000269|PubMed:20946981}.
uniprot
proteins
mass_dalton
77925
uniprot
proteins
mutagenesis
MUTAGEN 84; /note="M->A: Strongly reduced RNA editing activity."; /evidence="ECO:0000269|PubMed:20946981"; MUTAGEN 104..105; /note="VH->AA: Strongly reduced RNA editing activity."; /evidence="ECO:0000269|PubMed:20946981"; MUTAGEN 128; /note="K->A: Reduced RNA editing activity; when associated with A-281."; /evidence="ECO:0000269|PubMed:16472753"; MUTAGEN 238; /note="M->A: Strongly reduced RNA editing activity."; /evidence="ECO:0000269|PubMed:20946981"; MUTAGEN 258..259; /note="SH->AA: Abolishes RNA editing activity."; /evidence="ECO:0000269|PubMed:20946981"; MUTAGEN 281; /note="K->A: Reduced RNA editing activity; when associated with A-128."; /evidence="ECO:0000269|PubMed:16472753
uniprot
proteins
pubmed
16472753
uniprot
proteins
pubmed
20501795
uniprot
proteins
pubmed
20946981
uniprot
proteins
pubmed
8559253
uniprot
proteins
sequence_length
711
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P78563}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P78563}. Note=Shuttles between nucleoli and the nucleoplasm. {ECO:0000250|UniProtKB:P78563}.
uniprot
proteins