Sirpa
entrez
19261
canonical
uniprot
P97797
canonical
ensembl
ENSMUSG00000037902
resolver
ensp
ENSMUSP00000049022
resolver
ensp
ENSMUSP00000096713
resolver
ensp
ENSMUSP00000099491
resolver
ensp
ENSMUSP00000099492
resolver
ensp
ENSMUSP00000124048
resolver
ensp
ENSMUSP00000124888
resolver
ensp
ENSMUSP00000125004
resolver
ensp
ENSMUSP00000137611
resolver
ensp
ENSMUSP00000283443
resolver
ensp
ENSMUSP00000283449
resolver
ensp
ENSMUSP00000283458
resolver
ensp
ENSMUSP00000283476
resolver
enst
ENSMUST00000163034
resolver
genesymbol
Sirpa
resolver
genesymbol_syn
Bit
resolver
genesymbol_syn
Myd1
resolver
genesymbol_syn
Ptpns1
resolver
genesymbol_syn
Shps1
resolver
genesymbol_syn
Sirp
resolver
uniprot
A0A0R4J1Z7
resolver
uniprot
E0CX65
resolver
uniprot
E0CYM8
resolver
uniprot
E9QPT7
resolver
uniprot
O08907
resolver
uniprot
O35924
resolver
uniprot
O88555
resolver
uniprot
O88556
resolver
uniprot
P97796
resolver
uniprot
Q6P6I8
resolver
uniprot
Q8R559
resolver
uniprot
Q9QX57
resolver
uniprot
Q9WTN4
resolver
uniprot_entry
E0CX65_MOUSE
resolver
uniprot_entry
Q6P6I8_MOUSE
resolver
uniprot_entry
SHPS1_MOUSE
resolver
uniprot_sec
A0A0R4J1Z7
resolver
uniprot_sec
E0CYM8
resolver
uniprot_sec
E9QPT7
resolver
uniprot_sec
O08907
resolver
uniprot_sec
O35924
resolver
uniprot_sec
O88555
resolver
uniprot_sec
O88556
resolver
uniprot_sec
P97796
resolver
uniprot_sec
Q8R559
resolver
uniprot_sec
Q9QX57
resolver
uniprot_sec
Q9WTN4
resolver
amino_acid_sequence
MEPAGPAPGRLGPLLLCLLLSASCFCTGATGKELKVTQPEKSVSVAAGDSTVLNCTLTSLLPVGPIRWYRGVGPSRLLIYSFAGEYVPRIRNVSDTTKRNNMDFSIRISNVTPADAGIYYCVKFQKGSSEPDTEIQSGGGTEVYVLAKPSPPEVSGPADRGIPDQKVNFTCKSHGFSPRNITLKWFKDGQELHPLETTVNPSGKNVSYNISSTVRVVLNSMDVNSKVICEVAHITLDRSPLRGIANLSNFIRVSPTVKVTQQSPTSMNQVNLTCRAERFYPEDLQLIWLENGNVSRNDTPKNLTKNTDGTYNYTSLFLVNSSAHREDVVFTCQVKHDQQPAITRNHTVLGFAHSSDQGSMQTFPDNNATHNWNVFIGVGVACALLVVLLMAALYLLRIKQKKAKGSTSSTRLHEPEKNAREITQVQSLIQDTNDINDITYADLNLPKEKKPAPRAPEPNNHTEYASIETGKVPRPEDTLTYADLDMVHLSRAQPAPKPEPSFSEYASVQVQRK
uniprot
proteins
function
FUNCTION: Immunoglobulin-like cell surface receptor for CD47 (PubMed:18045614). Acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity). Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (PubMed:30726215). Receptor for THBS1 (By similarity). Interaction with THBS1 stimulates phosphorylation of SIRPA (By similarity). In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production (By similarity). {ECO:0000250|UniProtKB:P78324, ECO:0000250|UniProtKB:P97710, ECO:0000269|PubMed:18045614, ECO:0000269|PubMed:30726215}.
uniprot
proteins
mass_dalton
56414
uniprot
proteins
mutagenesis
MUTAGEN 441; /note="A->V: Almost complete loss of CD47 binding."; /evidence="ECO:0000269|PubMed:18045614
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10585853, ECO:0000269|PubMed:16944957, ECO:0000269|PubMed:9348339, ECO:0000269|PubMed:9507023, ECO:0000269|PubMed:9712903}.; PTM: Phosphorylated on tyrosine residues. {ECO:0000269|PubMed:9507023, ECO:0000269|PubMed:9712903}.
uniprot
proteins
pubmed
10585853
uniprot
proteins
pubmed
10662797
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
16944957
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18045614
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2303162
uniprot
proteins
pubmed
30726215
uniprot
proteins
pubmed
9070220
uniprot
proteins
pubmed
9073522
uniprot
proteins
pubmed
9348339
uniprot
proteins
pubmed
9507023
uniprot
proteins
pubmed
9712903
uniprot
proteins
pubmed
9872987
uniprot
proteins
sequence_length
513
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 374..394; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins