CD68
entrez
968
canonical
uniprot
P34810
canonical
ensembl
ENSG00000129226
resolver
ensp
ENSP00000250092
resolver
ensp
ENSP00000369867
resolver
genesymbol
CD68
resolver
hgnc
HGNC:1693
resolver
uniprot
B4DVT4
resolver
uniprot
Q53HR6
resolver
uniprot
Q53XI3
resolver
uniprot
Q96BI7
resolver
uniprot_entry
CD68_HUMAN
resolver
uniprot_sec
B4DVT4
resolver
uniprot_sec
Q53HR6
resolver
uniprot_sec
Q53XI3
resolver
uniprot_sec
Q96BI7
resolver
amino_acid_sequence
MRLAVLFSGALLGLLAAQGTGNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTTTHRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNATVHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRVMYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSYMAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCSNSSIILSPAVHLDLLSLRLQAAQLPHTGVFGQSFSCPSDRSILLPLIIGLILLGLLALVLIAFCIIRRRPSAYQAL
uniprot
proteins
function
FUNCTION: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
uniprot
proteins
mass_dalton
37408
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated. {ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:19159218}.
uniprot
proteins
protein_family
LAMP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15194571
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15647451
uniprot
proteins
pubmed
16263699
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18405323
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7680921
uniprot
proteins
pubmed
9790779
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Short]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Long]: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 320..344; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00740
uniprot
proteins