Fbxo39
entrez
303287
canonical
uniprot
Q66H10
canonical
ensembl
ENSRNOG00000014953
resolver
ensembl
ENSRNOG00055030756
resolver
ensembl
ENSRNOG00060022018
resolver
ensembl
ENSRNOG00065023715
resolver
ensp
ENSRNOP00000020071
resolver
ensp
ENSRNOP00055044119
resolver
ensp
ENSRNOP00060031422
resolver
ensp
ENSRNOP00065033095
resolver
enst
ENSRNOT00055053362
resolver
enst
ENSRNOT00060038126
resolver
enst
ENSRNOT00065040606
resolver
genesymbol
Fbxo39
resolver
uniprot
Q498T6
resolver
uniprot_entry
FBX39_RAT
resolver
uniprot_sec
Q498T6
resolver
amino_acid_sequence
MDEDSEVTQPQDQSCWATLPDVCLRRVFWWLGDRDRSRAALVCRKWNQIMYSADLWRYRTITFSGRPSRVHASEFESALWYVKKFGRYLEHLEIKFLNPYNAVLTKKFQVTMRGLLSCLGKSNNRLRSLSIQHLELDRLVWRNSIRGSLIKSLSFFLKKMGKHLDHLSLKGARLTVEQGCHILNSLSYMRNENVASELNIEDFFSHHLAVYGSSQFNKAMATFHNLTFLTLNYNCISDELLETLSENNAGTLRTMNIKCHVHDPHGQVVWGMSWAKLARQASNLKVNFFFERVMKYERLARILLQEIPVRSISLRSCYFSDPDWSMRPTLTDLLPTFRNTLQKLTFEFNNNHESLDEQLHLLILACRKLFYFKIWAFLDVKFVERILKSQEEGQCSLRTLKVRIYTNRYETNEEDRTLREIYRKYRKLIDSELNYFVIAYPMM
uniprot
proteins
function
FUNCTION: Testis-enriched substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Acts as a critical regulator of spermatogenesis, maintaining mitochondrial homeostasis to inhibit ferroptotic cell death. Mechanistically, targets lysine-specific demethylase 5A (KDM5A) for ubiquitin-dependent degradation. {ECO:0000250|UniProtKB:Q5NBU5}.
uniprot
proteins
mass_dalton
52504
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
443
uniprot
proteins