Figla
entrez
26910
canonical
uniprot
O55208
canonical
ensembl
ENSMUSG00000030001
resolver
ensp
ENSMUSP00000032070
resolver
enst
ENSMUST00000032070
resolver
genesymbol
Figla
resolver
uniprot
H6UWL1
resolver
uniprot_entry
FIGLA_MOUSE
resolver
uniprot_entry
H6UWL1_MOUSE
resolver
amino_acid_sequence
MDTAPASPEPFLVTPQAEVLEELIQAQMGPLPRLAAICRLKRLPSGGYSTTDDLHLVLERRRVANAKERERIKNLNRGFAKLKALVPFLPQSRKPSKVDILKGATEYIQILGCVLEEAKVSEKQSPEEQTHSGRPSDPHVSSTRELLGNATQPTSCASGLKKEEEGPWAYAGHSEPLYSYHQSTVPETRSYFTH
uniprot
proteins
function
FUNCTION: Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. {ECO:0000269|PubMed:11023867}.
uniprot
proteins
mass_dalton
21529
uniprot
proteins
pubmed
11023867
uniprot
proteins
pubmed
9362457
uniprot
proteins
sequence_length
194
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins