Rnf183
entrez
76072
canonical
uniprot
Q8QZS5
canonical
ensembl
ENSMUSG00000063851
resolver
ensp
ENSMUSP00000078389
resolver
ensp
ENSMUSP00000103078
resolver
ensp
ENSMUSP00000103079
resolver
enst
ENSMUST00000079420
resolver
enst
ENSMUST00000107454
resolver
enst
ENSMUST00000107455
resolver
genesymbol
Rnf183
resolver
uniprot
B7ZCH3
resolver
uniprot
Q5NBV8
resolver
uniprot_entry
RN183_MOUSE
resolver
uniprot_sec
B7ZCH3
resolver
uniprot_sec
Q5NBV8
resolver
amino_acid_sequence
MSEPQGQELRAECPVCWNPFNNTFHTPKVLDCCHSFCVECLAHLSLVTPARRRLLCPLCRQPTVLASGQPVTDLPTDTAMLTLLRLEPHHVILEGHQLCLKDQPKSRYFLRQPRVYTLDLGAEPGSQTGLPQDTAPDTRPVPIPSHYSLRECVRNPHFRIFAYLMAVILSVTLLLIFSIFWTKQFFWGMG
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Acts as an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29300766, PubMed:31732153). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (By similarity). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (By similarity). Mediates the ubiquitination and subsequent lysosomal degradation of ATP1B1 (PubMed:31732153). {ECO:0000250|UniProtKB:Q96D59, ECO:0000269|PubMed:29300766, ECO:0000269|PubMed:31732153}.
uniprot
proteins
mass_dalton
21625
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="C->S: Decrease in autoubiquitination; when associated with S-16."; /evidence="ECO:0000269|PubMed:29300766"; MUTAGEN 16; /note="C->S: Decrease in autoubiquitination; when associated with S-13."; /evidence="ECO:0000269|PubMed:29300766
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:29300766}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated (in vitro). {ECO:0000269|PubMed:29300766}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
29300766
uniprot
proteins
pubmed
29507230
uniprot
proteins
pubmed
31732153
uniprot
proteins
sequence_length
190
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29300766}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q96D59}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q96D59}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:29300766}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q96D59}. Lysosome membrane {ECO:0000269|PubMed:29300766, ECO:0000269|PubMed:31732153}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q96D59}.
uniprot
proteins
transmembrane_region
TRANSMEM 160..180; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins