Nudt21
entrez
291877
canonical
uniprot
Q4KM65
canonical
ensembl
ENSRNOG00000042983
resolver
ensembl
ENSRNOG00055021547
resolver
ensembl
ENSRNOG00060015572
resolver
ensembl
ENSRNOG00065004058
resolver
ensp
ENSRNOP00000099169
resolver
ensp
ENSRNOP00000103396
resolver
ensp
ENSRNOP00055029934
resolver
ensp
ENSRNOP00060021368
resolver
ensp
ENSRNOP00065004265
resolver
enst
ENSRNOT00000150195
resolver
enst
ENSRNOT00055036847
resolver
enst
ENSRNOT00060026693
resolver
enst
ENSRNOT00065005947
resolver
genesymbol
Nudt21
resolver
genesymbol_syn
Cpsf5
resolver
uniprot
A0ABK0LD78
resolver
uniprot
B4F764
resolver
uniprot_entry
A0ABK0LD78_RAT
resolver
uniprot_entry
B4F764_RAT
resolver
uniprot_entry
CPSF5_RAT
resolver
amino_acid_sequence
MSVVPPNRSQTGWPRGVNQFGNKYIQQTKPLTLERTINLYPLTNYTFGTKEPLYEKDSSVAARFQRMREEFDKIGMRRTVEGVLIVHEHRLPHVLLLQLGTTFFKLPGGELNPGEDEVEGLKRLMTEILGRQDGVLQDWVIDDCIGNWWRPNFEPPQYPYIPAHITKPKEHKKLFLVQLQEKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQLLSRFNFIYN
uniprot
proteins
function
FUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7. Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function. Binds to chromatin. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. {ECO:0000250|UniProtKB:O43809, ECO:0000250|UniProtKB:Q9CQF3}.
uniprot
proteins
mass_dalton
26240
uniprot
proteins
post_translational_modification
PTM: Acetylated mainly by p300/CBP, recruited to the complex by CPSF6. Acetylation decreases interaction with PAPAO. Deacetylated by the class I/II HDACs, HDAC1, HDAC3 and HDAC10, and by the class III HDACs, SIRT1 and SIRT2. {ECO:0000250|UniProtKB:O43809}.
uniprot
proteins
protein_family
CPSF5 subfamily
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
227
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43809}. Cytoplasm {ECO:0000250|UniProtKB:O43809}. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm). In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles. {ECO:0000250|UniProtKB:O43809}.
uniprot
proteins