IKZF3
entrez
22806
canonical
uniprot
Q9UKT9
canonical
ensembl
ENSG00000161405
resolver
ensp
ENSP00000341977
resolver
ensp
ENSP00000344471
resolver
ensp
ENSP00000344544
resolver
ensp
ENSP00000345622
resolver
ensp
ENSP00000367179
resolver
ensp
ENSP00000367180
resolver
ensp
ENSP00000367188
resolver
ensp
ENSP00000367194
resolver
ensp
ENSP00000377741
resolver
ensp
ENSP00000403027
resolver
ensp
ENSP00000403776
resolver
ensp
ENSP00000420463
resolver
ensp
ENSP00000438972
resolver
ensp
ENSP00000462452
resolver
ensp
ENSP00000485515
resolver
genesymbol
IKZF3
resolver
genesymbol_syn
ZNFN1A3
resolver
hgnc
HGNC:13178
resolver
uniprot
B4DVV5
resolver
uniprot
Q69BL6
resolver
uniprot
Q69BL7
resolver
uniprot
Q69BL8
resolver
uniprot
Q69BL9
resolver
uniprot
Q69BM0
resolver
uniprot
Q69BM1
resolver
uniprot
Q69BM2
resolver
uniprot
Q69BM3
resolver
uniprot
Q69BM5
resolver
uniprot
Q8N574
resolver
uniprot
Q8WWQ9
resolver
uniprot
Q8WWR0
resolver
uniprot
Q8WWR1
resolver
uniprot
Q8WWR2
resolver
uniprot
Q8WWR3
resolver
uniprot_entry
IKZF3_HUMAN
resolver
uniprot_sec
B4DVV5
resolver
uniprot_sec
Q69BL6
resolver
uniprot_sec
Q69BL7
resolver
uniprot_sec
Q69BL8
resolver
uniprot_sec
Q69BL9
resolver
uniprot_sec
Q69BM0
resolver
uniprot_sec
Q69BM1
resolver
uniprot_sec
Q69BM2
resolver
uniprot_sec
Q69BM3
resolver
uniprot_sec
Q69BM5
resolver
uniprot_sec
Q8N574
resolver
uniprot_sec
Q8WWQ9
resolver
uniprot_sec
Q8WWR0
resolver
uniprot_sec
Q8WWR1
resolver
uniprot_sec
Q8WWR2
resolver
uniprot_sec
Q8WWR3
resolver
amino_acid_sequence
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDDSMKVKDEYSERDENVLKSEPMGNAEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKMNCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRTFLQSTDPGDTASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRALLK
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 84 (IMD84) [MIM:619437]: An autosomal recessive immunologic disorder characterized by recurrent sinopulmonary infections from childhood associated with low levels of B cells and impaired early B-cell development. There may also be variable T-cell abnormalities. Patients have increased susceptibility to infection with Epstein-Barr virus and a propensity for the development of lymphoma in adulthood. {ECO:0000269|PubMed:34155405}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. {ECO:0000269|PubMed:10369681, ECO:0000269|PubMed:34155405}.
uniprot
proteins
mass_dalton
58023
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells. {ECO:0000269|PubMed:10369681, ECO:0000269|PubMed:11714801}.
uniprot
proteins
protein_family
Ikaros C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
10369681
uniprot
proteins
pubmed
10552935
uniprot
proteins
pubmed
10978333
uniprot
proteins
pubmed
11714801
uniprot
proteins
pubmed
11745366
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17646674
uniprot
proteins
pubmed
20676092
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
34155405
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10369681}. Cytoplasm {ECO:0000269|PubMed:10369681}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:17646674, ECO:0000269|PubMed:34155405}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:17646674}.; SUBCELLULAR LOCATION: [Isoform 11]: Nucleus {ECO:0000269|PubMed:17646674}.; SUBCELLULAR LOCATION: [Isoform 14]: Nucleus {ECO:0000269|PubMed:17646674}. Cytoplasm {ECO:0000269|PubMed:17646674}.; SUBCELLULAR LOCATION: [Isoform 12]: Cytoplasm {ECO:0000269|PubMed:17646674}.
uniprot
proteins