GRAMD1A
entrez
57655
canonical
uniprot
Q96CP6
canonical
ensembl
ENSG00000089351
resolver
ensp
ENSP00000439267
resolver
ensp
ENSP00000441032
resolver
ensp
ENSP00000470220
resolver
ensp
ENSP00000505404
resolver
enst
ENST00000599564
resolver
genesymbol
GRAMD1A
resolver
genesymbol_syn
KIAA1533
resolver
hgnc
HGNC:29305
resolver
uniprot
A6NKY7
resolver
uniprot
B3KQF7
resolver
uniprot
B3KUH3
resolver
uniprot
M0QZ12
resolver
uniprot
Q8NC77
resolver
uniprot
Q9P1Z5
resolver
uniprot_entry
ASTRA_HUMAN
resolver
uniprot_entry
B3KQF7_HUMAN
resolver
uniprot_entry
B3KUH3_HUMAN
resolver
uniprot_entry
M0QZ12_HUMAN
resolver
uniprot_sec
A6NKY7
resolver
uniprot_sec
Q8NC77
resolver
uniprot_sec
Q9P1Z5
resolver
amino_acid_sequence
MFDTTPHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPSTQSLGSRNFIRNSKKMQSWYSMLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLGTPKEVGDVIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVDSQPDASSSQTVTPVAEPPSTEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLAALLPDLSGRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQCKFTDVTLSPWSGDSKCHQRRVLTYTIPISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYCILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEEGGKDARGLLSGLRRRKRPLSWRAHGDGPQHPDPDPCARAGIHTSGSLSSRFSEPSVDQGPGAGIPSALVLISIVICVSLIILIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFPQTATEWAEILALQKQFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVSDPPFDTQPRPDDSFS
uniprot
proteins
function
FUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}.
uniprot
proteins
mass_dalton
80680
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27585821
uniprot
proteins
pubmed
29469807
uniprot
proteins
pubmed
31222192
uniprot
proteins
sequence_length
724
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29469807}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:29469807}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:31222192}. Note=In lipid-poor conditions localizes to the ER membrane and is recruited to endoplasmic reticulum-plasma membrane contact sites (EPCS) in response to excess cholesterol in the PM (By similarity). Localizes to distinct EPCS than GRAMD2A and ESYT2/3 (PubMed:29469807). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:29469807}.
uniprot
proteins
transmembrane_region
TRANSMEM 610..630; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins