Foxl2
entrez
26927
canonical
uniprot
O88470
canonical
ensembl
ENSMUSG00000050397
resolver
ensp
ENSMUSP00000053297
resolver
enst
ENSMUST00000051312
resolver
genesymbol
Foxl2
resolver
genesymbol_syn
Pfrk
resolver
uniprot
Q2TVT7
resolver
uniprot
Q8K3X9
resolver
uniprot_entry
FOXL2_MOUSE
resolver
uniprot_entry
Q2TVT7_MOUSE
resolver
uniprot_sec
Q8K3X9
resolver
amino_acid_sequence
MMASYPEPEDTAGTLLAPESGRAVKEAEASPPSPGKGGGTTPEKPDPAQKPPYSYVALIAMAIRESAEKRLTLSGIYQYIIAKFPFYEKNKKGWQNSIRHNLSLNECFIKVPREGGGERKGNYWTLDPACEDMFEKGNYRRRRRMKRPFRPPPAHFQPGKGLFGSGGAAGGCGVPGAGADGYGYLAPPKYLQSGFLNNSWPLPQPPSPMPYASCQMAAAAAAAAAAAAAAGPGSPGAAAVVKGLAGPAASYGPYSRVQSMALPPGVVNSYNGLGGPPAAPPPPPPPPHPHPHPHAHHLHAAAAPPPAPPHHGAAAPPPGQLSPASPATAAPPAPAPTSAPGLQFACARQPELAMMHCSYWDHDSKTGALHSRLDL
uniprot
proteins
function
FUNCTION: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Is a regulator of CYP19 expression. Is a transcriptional repressor of STAR. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element. {ECO:0000269|PubMed:15059956, ECO:0000269|PubMed:15944199, ECO:0000269|PubMed:19106105, ECO:0000269|PubMed:19797124, ECO:0000269|PubMed:20005806}.
uniprot
proteins
mass_dalton
38887
uniprot
proteins
post_translational_modification
PTM: Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity. {ECO:0000250}.
uniprot
proteins
pubmed
12471206
uniprot
proteins
pubmed
15059956
uniprot
proteins
pubmed
15944199
uniprot
proteins
pubmed
16153597
uniprot
proteins
pubmed
19106105
uniprot
proteins
pubmed
19797124
uniprot
proteins
pubmed
20005806
uniprot
proteins
pubmed
9620855
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:19797124}.
uniprot
proteins