Dhcr7
entrez
13360
canonical
uniprot
O88455
canonical
ensembl
ENSMUSG00000058454
resolver
ensp
ENSMUSP00000073541
resolver
ensp
ENSMUSP00000117659
resolver
ensp
ENSMUSP00000121782
resolver
ensp
ENSMUSP00000146947
resolver
ensp
ENSMUSP00000216416
resolver
ensp
ENSMUSP00000216418
resolver
ensp
ENSMUSP00000216420
resolver
ensp
ENSMUSP00000216428
resolver
ensp
ENSMUSP00000216437
resolver
ensp
ENSMUSP00000346443
resolver
enst
ENSMUST00000073878
resolver
enst
ENSMUST00000124340
resolver
enst
ENSMUST00000141916
resolver
enst
ENSMUST00000207143
resolver
genesymbol
Dhcr7
resolver
uniprot
A0A140LIT2
resolver
uniprot_entry
A0A140LIT2_MOUSE
resolver
uniprot_entry
DHCR7_MOUSE
resolver
amino_acid_sequence
MASKSQHNAPKVKSPNGKAGSQGQWGRAWEVDWFSLASIIFLLLFAPFIVYYFIMACDQYSCSLTAPALDIATGHASLADIWAKTPPVTAKAAQLYALWVSFQVLLYSWLPDFCHRFLPGYVGGVQEGAITPAGVVNKYEVNGLQAWLITHILWFVNAYLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIKGYLFPTSAEDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMILVNVLQAIYVLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPNALGILLLGLVGYYIFRMTNHQKDLFRRTDGRCLIWGKKPKAIECSYTSADGLKHHSKLLVSGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIYMTILLTHRCLRDEHRCANKYGRDWERYTAAVPYRLLPGIF
uniprot
proteins
ec_number
1.3.1.21
uniprot
proteins
function
FUNCTION: Oxidoreductase that catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core (PubMed:11230174, PubMed:38297130). Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol (PubMed:11230174). Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation (PubMed:38297130). {ECO:0000269|PubMed:11230174, ECO:0000269|PubMed:38297130}.; FUNCTION: Together with cholestenol Delta-isomerase/EBP, forms part of the microsomal antiestrogen binding site (AEBS), a multiprotein complex located in the ER membrane. This complex is responsible for cholesterol-5,6-epoxide hydrolase (ChEH) activity, which consists in the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3beta,5alpha,6beta-triol (CT). Within this complex, it cooperates in the binding of substrates to ChEH, while EBP carries the catalytic activity. {ECO:0000250|UniProtKB:Q9UBM7}.
uniprot
proteins
mass_dalton
53919
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; cholesterol biosynthesis. {ECO:0000269|PubMed:11230174}.
uniprot
proteins
protein_family
ERG4/ERG24 family
uniprot
proteins
pubmed
11230174
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
38297130
uniprot
proteins
pubmed
9653161
uniprot
proteins
sequence_length
471
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UBM7}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 95..115; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 262..282; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 302..322; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 327..347; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 416..436; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins