TAFA5
entrez
25817
canonical
uniprot
Q7Z5A7
canonical
ensembl
ENSG00000219438
resolver
ensp
ENSP00000351043
resolver
ensp
ENSP00000383933
resolver
genesymbol
TAFA5
resolver
genesymbol_syn
FAM19A5
resolver
hgnc
HGNC:21592
resolver
uniprot
A6NII9
resolver
uniprot
B0QZ13
resolver
uniprot
B0QZ14
resolver
uniprot
B0QZ15
resolver
uniprot
O95902
resolver
uniprot
Q5H9C4
resolver
uniprot
Q6UWC9
resolver
uniprot
Q8IXR8
resolver
uniprot_entry
TAFA5_HUMAN
resolver
uniprot_sec
A6NII9
resolver
uniprot_sec
B0QZ13
resolver
uniprot_sec
B0QZ14
resolver
uniprot_sec
B0QZ15
resolver
uniprot_sec
O95902
resolver
uniprot_sec
Q5H9C4
resolver
uniprot_sec
Q6UWC9
resolver
uniprot_sec
Q8IXR8
resolver
amino_acid_sequence
MAPSPRTGSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDARIIKTKQWCDMLPCLEGEGCDLLINRSGWTCTQPGGRIKTTTVS
uniprot
proteins
function
FUNCTION: Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2 (By similarity). Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (By similarity). {ECO:0000250|UniProtKB:M0R7X9, ECO:0000250|UniProtKB:Q91WE9}.
uniprot
proteins
mass_dalton
14301
uniprot
proteins
protein_family
TAFA family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15028294
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
29453251
uniprot
proteins
sequence_length
132
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15028294, ECO:0000269|PubMed:29453251}.
uniprot
proteins