AF1Q
entrez
10962
canonical
uniprot
Q13015
canonical
ensembl
ENSG00000213190
resolver
ensp
ENSP00000357917
resolver
ensp
ENSP00000560032
resolver
ensp
ENSP00000560033
resolver
ensp
ENSP00000560034
resolver
ensp
ENSP00000560035
resolver
ensp
ENSP00000589137
resolver
ensp
ENSP00000589138
resolver
ensp
ENSP00000589139
resolver
enst
ENST00000368921
resolver
enst
ENST00000889973
resolver
enst
ENST00000889974
resolver
enst
ENST00000889975
resolver
enst
ENST00000889976
resolver
enst
ENST00000919078
resolver
enst
ENST00000919079
resolver
enst
ENST00000919080
resolver
genesymbol
AF1Q
resolver
genesymbol
MLLT11
resolver
genesymbol_syn
AF1Q
resolver
genesymbol_syn
MLLT11
resolver
hgnc
HGNC:16997
resolver
uniprot
Q6FGF7
resolver
uniprot_entry
AF1Q_HUMAN
resolver
uniprot_entry
Q6FGF7_HUMAN
resolver
amino_acid_sequence
MRDPVSSQYSSFLFWRMPIPELDLSELEGLGLSDTATYKVKDSSVGKMIGQATAADQEKNPEGDGLLEYSTFNFWRAPIASIHSFELDLL
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1.
uniprot
proteins
function
FUNCTION: Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312). {ECO:0000269|PubMed:21715312, ECO:0000269|PubMed:26079538}.
uniprot
proteins
mass_dalton
10061
uniprot
proteins
mutagenesis
MUTAGEN 24..32; /note="LSELEGLGL->ASEAEGAGA: Constitutive nuclear sequestration."; /evidence="ECO:0000269|PubMed:21715312
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to degradation. {ECO:0000269|PubMed:21715312}.
uniprot
proteins
protein_family
MLLT11 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21715312
uniprot
proteins
pubmed
24880125
uniprot
proteins
pubmed
26079538
uniprot
proteins
pubmed
7833468
uniprot
proteins
sequence_length
90
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21715312, ECO:0000269|PubMed:26079538}. Cytoplasm {ECO:0000269|PubMed:21715312, ECO:0000269|PubMed:26079538}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21715312}. Note=Continuous nuclear export is followed by degradation. {ECO:0000269|PubMed:21715312}.
uniprot
proteins