Rnf187
entrez
360533
canonical
uniprot
D3Z8N2
canonical
genesymbol
Rnf187
resolver
uniprot_entry
RN187_RAT
resolver
amino_acid_sequence
MALPAGPAEAICALCQRAPREPVRADCGHRFCRACVVRFWAEEDGPFPCPECADDCWQRAVEPSRPPLSRRLLALEEAAAAPARDGPASEAALQLLCRADGDPLCSACRMAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVMDRRKKALTDYKKLRAFFVEEEEHFLQEAEKDEGASDDDELADPADRFRSLLQAVSELEKKHRNLGLSMLLQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8. {ECO:0000250|UniProtKB:Q5TA31}.
uniprot
proteins
mass_dalton
26313
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; undergoes 'Lys-48'-linked autoubiquitination in the absence of growth factors and MAP3K1-induced 'Lys-63'-linked polyubiquitination. 'Lys-48'-autoubiquitination leads to degradation by the proteasome, while MAP3K1-induced 'Lys-63'-linked polyubiquitination results in the stabilization of the protein. 'Lys-48'- and 'Lys-63'-linked polyubiquitinations occur most probably on the same 3 C-terminal lysine residues (Lys-195, Lys-224 and Lys-225) and are thus mutually exclusive. Other sites of ubiquitination are not excluded. 'Lys-63'-linked polyubiquitination by TRIM7 in response to growth factor signaling via the MEK/ERK pathway enhances protein stability. {ECO:0000250|UniProtKB:Q5TA31}.; PTM: Arginine methylation by PRMT1 stabilizes RNF187 by facilitating K63-linked ubiquitin chain formation, and enables dimerization, c-Jun interaction and subsequent AP1 target gene expression. {ECO:0000250|UniProtKB:Q5TA31}.
uniprot
proteins
pubmed
20852630
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5TA31}. Nucleus {ECO:0000250|UniProtKB:Q5TA31}. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250|UniProtKB:Q5TA31}.
uniprot
proteins