Mfng
entrez
17305
canonical
uniprot
O09008
canonical
ensembl
ENSMUSG00000018169
resolver
ensp
ENSMUSP00000018313
resolver
enst
ENSMUST00000018313
resolver
genesymbol
Mfng
resolver
uniprot
Q3UPI0
resolver
uniprot_entry
MFNG_MOUSE
resolver
uniprot_entry
Q3UPI0_MOUSE
resolver
amino_acid_sequence
MHCRLFRGMAGALFTLLCVGLLSLRYHSSLSQRMIQGALRLNQRNPGPLELQLGDIFIAVKTTWAFHRSRLDLLLDTWVSRIRQQTFIFTDSPDERLQERLGPHLVVTNCSAEHSHPALSCKMAAEFDAFLVSGLRWFCHVDDDNYVNPKALLQLLKTFPQDRDVYVGKPSLNRPIHASELQSKNRTKLVRFWFATGGAGFCINRQLALKMVPWASGSHFVDTSALIRLPDDCTVGYIIECKLGGRLQPSPLFHSHLETLQLLGAAQLPEQVTLSYGVFEGKLNVIKLPGPFSHEEDPSRFRSLHCLLYPDTPWCPLLAAP
uniprot
proteins
ec_number
2.4.1.222
uniprot
proteins
function
FUNCTION: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (PubMed:10935626, PubMed:28089369). {ECO:0000269|PubMed:10935626, ECO:0000269|PubMed:28089369}.
uniprot
proteins
mass_dalton
36200
uniprot
proteins
protein_family
Glycosyltransferase 31 family
uniprot
proteins
pubmed
10935626
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16221665
uniprot
proteins
pubmed
16964258
uniprot
proteins
pubmed
28089369
uniprot
proteins
pubmed
9187150
uniprot
proteins
pubmed
9207795
uniprot
proteins
sequence_length
321
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..27; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins