TNFRSF8
entrez
943
canonical
uniprot
P28908
canonical
ensembl
ENSG00000120949
resolver
ensp
ENSP00000263932
resolver
ensp
ENSP00000390650
resolver
ensp
ENSP00000756323
resolver
ensp
ENSP00000756324
resolver
genesymbol
TNFRSF8
resolver
genesymbol_syn
CD30
resolver
genesymbol_syn
D1S166E
resolver
hgnc
HGNC:11923
resolver
uniprot
A5D8T4
resolver
uniprot
B1AN79
resolver
uniprot
B9EGD9
resolver
uniprot
D3YTD8
resolver
uniprot
Q6P4D9
resolver
uniprot_entry
A5D8T4_HUMAN
resolver
uniprot_entry
TNR8_HUMAN
resolver
uniprot_sec
B1AN79
resolver
uniprot_sec
B9EGD9
resolver
uniprot_sec
D3YTD8
resolver
uniprot_sec
Q6P4D9
resolver
amino_acid_sequence
MRVLLAALGLLFLGALRAFPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQRPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVNSCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPTPVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDCRKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARCVPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHRRACRKRIRQKLHLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPTAASGK
uniprot
proteins
function
FUNCTION: Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898). {ECO:0000269|PubMed:8391931, ECO:0000269|PubMed:8999898}.
uniprot
proteins
mass_dalton
63747
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and tyrosine residues (Probable). Isoform 2 is constitutively phosphorylated (PubMed:8839832). {ECO:0000269|PubMed:8839832, ECO:0000305}.
uniprot
proteins
protein_family
TNFR8 family
uniprot
proteins
pubmed
10518213
uniprot
proteins
pubmed
1310894
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
7527901
uniprot
proteins
pubmed
8391931
uniprot
proteins
pubmed
8627180
uniprot
proteins
pubmed
8839832
uniprot
proteins
pubmed
8999898
uniprot
proteins
pubmed
9168896
uniprot
proteins
pubmed
9511754
uniprot
proteins
sequence_length
595
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:8391931, ECO:0000305|PubMed:8999898}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:8839832}.
uniprot
proteins
transmembrane_region
TRANSMEM 386..406; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins