Clpp
entrez
53895
canonical
uniprot
O88696
canonical
ensembl
ENSMUSG00000002660
resolver
ensp
ENSMUSP00000002735
resolver
enst
ENSMUST00000002735
resolver
genesymbol
Clpp
resolver
uniprot
Q3TI13
resolver
uniprot_entry
CLPP_MOUSE
resolver
uniprot_sec
Q3TI13
resolver
amino_acid_sequence
MWPRVLLGEARVAVDGCRALLSRLAVHFSPPWTAVSCSPLRRSLHGTATRAFPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGSPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEPELVQKETATAPTDPPAPTST
uniprot
proteins
ec_number
3.4.21.92
uniprot
proteins
function
FUNCTION: Protease component of the ClpXP complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The ClpXP complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion. {ECO:0000250|UniProtKB:Q16740}.
uniprot
proteins
mass_dalton
29800
uniprot
proteins
protein_family
Peptidase S14 family
uniprot
proteins
pubmed
10754102
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22710082
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
23851121
uniprot
proteins
sequence_length
272
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:10754102, ECO:0000269|PubMed:22710082}.
uniprot
proteins