CEACAM5
entrez
1048
canonical
uniprot
P06731
canonical
ensembl
ENSG00000105388
resolver
ensp
ENSP00000221992
resolver
ensp
ENSP00000381600
resolver
ensp
ENSP00000385072
resolver
ensp
ENSP00000482157
resolver
ensp
ENSP00000482303
resolver
ensp
ENSP00000558570
resolver
ensp
ENSP00000558576
resolver
ensp
ENSP00000558589
resolver
ensp
ENSP00000618484
resolver
enst
ENST00000615021
resolver
enst
ENST00000617332
resolver
genesymbol
CEACAM5
resolver
genesymbol_syn
CEA
resolver
hgnc
HGNC:1817
resolver
uniprot
A0A024R0K5
resolver
uniprot
A0A087WYX0
resolver
uniprot
H9KVA7
resolver
uniprot
Q53G30
resolver
uniprot_entry
A0A024R0K5_HUMAN
resolver
uniprot_entry
A0A087WYX0_HUMAN
resolver
uniprot_entry
CEAM5_HUMAN
resolver
uniprot_entry
Q53G30_HUMAN
resolver
uniprot_sec
H9KVA7
resolver
amino_acid_sequence
MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSAGATVGIMIGVLVGVALI
uniprot
proteins
function
FUNCTION: Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050). {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:10910050, ECO:0000269|PubMed:2803308}.; FUNCTION: (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. {ECO:0000269|PubMed:18086185}.
uniprot
proteins
mass_dalton
76796
uniprot
proteins
mutagenesis
MUTAGEN 63; /note="F->I: No effect on dimerization. Reduced affinity for E.coli Dr adhesins."; /evidence="ECO:0000269|PubMed:18086185"; MUTAGEN 63; /note="F->R: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins."; /evidence="ECO:0000269|PubMed:18086185"; MUTAGEN 66; /note="S->N: Abolishes dimerization."; /evidence="ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185"; MUTAGEN 68; /note="Y->A: Abolishes dimerization."; /evidence="ECO:0000269|PubMed:10864933"; MUTAGEN 68; /note="Y->F: No effect on dimerization."; /evidence="ECO:0000269|PubMed:10864933"; MUTAGEN 69; /note="K->A: Abolishes dimerization."; /evidence="ECO:0000269|PubMed:10864933"; MUTAGEN 73; /note="V->A: Abolishes dimerization."; /evidence="ECO:0000269|PubMed:18086185"; MUTAGEN 74; /note="D->A: No effect on dimerization."; /evidence="ECO:0000269|PubMed:18086185"; MUTAGEN 74; /note="D->L,R: Abolishes dimerization."; /evidence="ECO:0000269|PubMed:18086185"; MUTAGEN 78; /note="Q->L,R: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins."; /evidence="ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185"; MUTAGEN 125; /note="I->A: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins."; /evidence="ECO:0000269|PubMed:18086185"; MUTAGEN 129; /note="L->A,C: No effect on dimerization. Reduced affinity for E.coli Dr adhesins."; /evidence="ECO:0000269|PubMed:18086185"; MUTAGEN 129; /note="L->S: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins."; /evidence="ECO:0000269|PubMed:18086185"; MUTAGEN 133; /note="E->A: Abolishes dimerization."; /evidence="ECO:0000269|PubMed:18086185
uniprot
proteins
post_translational_modification
PTM: Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
uniprot
proteins
protein_family
CEA family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
10436421
uniprot
proteins
pubmed
10854848
uniprot
proteins
pubmed
10864933
uniprot
proteins
pubmed
10910050
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
16740002
uniprot
proteins
pubmed
18086185
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
2317824
uniprot
proteins
pubmed
2342461
uniprot
proteins
pubmed
26483485
uniprot
proteins
pubmed
2803308
uniprot
proteins
pubmed
3033671
uniprot
proteins
pubmed
3220478
uniprot
proteins
pubmed
3387431
uniprot
proteins
pubmed
3670312
uniprot
proteins
pubmed
3814146
uniprot
proteins
sequence_length
702
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185, ECO:0000269|PubMed:2317824, ECO:0000269|PubMed:2803308, ECO:0000269|PubMed:3387431}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185, ECO:0000269|PubMed:2317824, ECO:0000269|PubMed:2803308, ECO:0000269|PubMed:3387431}; Extracellular side {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185, ECO:0000269|PubMed:2317824, ECO:0000269|PubMed:2803308, ECO:0000269|PubMed:3387431}. Apical cell membrane {ECO:0000269|PubMed:10436421}. Cell surface {ECO:0000269|PubMed:2317824, ECO:0000269|PubMed:2803308}. Note=Localized to the apical glycocalyx surface. {ECO:0000269|PubMed:10436421}.
uniprot
proteins