Klhdc10
entrez
312199
canonical
uniprot
Q5U3Y0
canonical
ensembl
ENSRNOG00000010267
resolver
ensembl
ENSRNOG00055021500
resolver
ensembl
ENSRNOG00060022296
resolver
ensembl
ENSRNOG00065026706
resolver
ensp
ENSRNOP00000038586
resolver
ensp
ENSRNOP00000106559
resolver
ensp
ENSRNOP00055029827
resolver
ensp
ENSRNOP00060031900
resolver
ensp
ENSRNOP00065037803
resolver
enst
ENSRNOT00000034429
resolver
enst
ENSRNOT00000096895
resolver
enst
ENSRNOT00055036733
resolver
enst
ENSRNOT00060038642
resolver
enst
ENSRNOT00065046076
resolver
genesymbol
Klhdc10
resolver
uniprot
A0ABK0LXK3
resolver
uniprot_entry
A0ABK0LXK3_RAT
resolver
uniprot_entry
KLD10_RAT
resolver
amino_acid_sequence
MSAAQGWDRNRRRGGGAAGGASGVSGAGAAGGGRGTGQLNRFVQLSGRPHLPGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKRPSRIYGQAMALINGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNLANLSRTQLLHLGLTQELIERLK
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C-terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) or an alanine tail (CAT tail) at the C-terminus, leading to their ubiquitination and degradation (By similarity). The CRL2(KLHDC10) complex is involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: CRL2(KLHDC10) acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (By similarity). Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5 (By similarity). Acts as a regulator of necroptosis (By similarity). {ECO:0000250|UniProtKB:Q6PAR0, ECO:0000250|UniProtKB:Q6PID8}.
uniprot
proteins
mass_dalton
45380
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q6PID8}.
uniprot
proteins
protein_family
KLHDC10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6PID8}. Cytoplasm {ECO:0000250|UniProtKB:Q6PID8}.
uniprot
proteins