Sh3rf2
entrez
269016
canonical
uniprot
Q8BZT2
canonical
ensembl
ENSMUSG00000057719
resolver
ensp
ENSMUSP00000071896
resolver
ensp
ENSMUSP00000074247
resolver
ensp
ENSMUSP00000223904
resolver
genesymbol
Sh3rf2
resolver
genesymbol_syn
Posh3
resolver
genesymbol_syn
Ppp1r39
resolver
genesymbol_syn
Rnf158
resolver
uniprot
B2RQJ2
resolver
uniprot
Q80VJ1
resolver
uniprot
Q8C122
resolver
uniprot
Q8C1E3
resolver
uniprot_entry
SH3R2_MOUSE
resolver
uniprot_sec
B2RQJ2
resolver
uniprot_sec
Q80VJ1
resolver
uniprot_sec
Q8C122
resolver
uniprot_sec
Q8C1E3
resolver
amino_acid_sequence
MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRIFKAHKELRCPECRTLVFCSIEALPANLLLVRLLDGVRSGQSSWKGGSFRRPRILTLQDNRKAKSSPRSLQASPFRLVPSVRIHMDGVPRAKALCNYRGKNPGDLKFNKGDVILLRRQLDENWYQGEINGVSGIFPASSVEVIKQLPQPPPLCRALYNFDLRDKDKSENQDCLTFLKDDVITVISRVDENWAEGKLGDKVGIFPILFVEPNVSARHLLENKGHQLSRTRHLSLMSSPSRGKATNTSSLRKSPGSRRKGSGQFSMTTALNTLNRTVHSPEGHQMVEISTPMLISSNSPSVLTQHGDKADFPTSSTGQVSSSQPAPASPGHSTAMVSVPSSQQHLSNNMFVALHTYSAHRPEELDLQKGEGIRVLGKYQDGWLKGLSLLTGRTGIFPSDYVIPVFSSTARKTSSFPDSRSPTVCTTWALSTSSVSSQGSFAEGDPRQSGPFKSVFVPTAVVNPSRSTPGPGSSGQGSLRKVRSSMRKNGSLQRPVQSGIPTFMVGSLRCSPTMVIRPQRFQFYPPQGMTPSPTPIMVEMGSKSIYTGEPALTCINRGSKTRIHSAGNSIIMEGKETPIKSEPPPKPPASAPPSILVKPENSKNGTEKQVKTVRFQNYSPPPTKHSASSPTSGKHDHPATLKGSQHEAVSSGGEMTILFAHRSGCHSGQQTDLRRKSAFGKTMPLLSTASATQTLFPSK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Has E3 ubiquitin-protein ligase activity. Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation. Facilitates TNF-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity (By similarity). {ECO:0000250|UniProtKB:Q8TEC5}.
uniprot
proteins
mass_dalton
80066
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000250|UniProtKB:Q8TEC5}.
uniprot
proteins
protein_family
SH3RF family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
735
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TEC5}.
uniprot
proteins