Ggt1
entrez
116568
canonical
uniprot
P07314
canonical
ensembl
ENSRNOG00000047697
resolver
ensembl
ENSRNOG00055021266
resolver
ensembl
ENSRNOG00060024316
resolver
ensembl
ENSRNOG00065000398
resolver
ensembl
ENSRNOG00065026858
resolver
ensp
ENSRNOP00000065923
resolver
ensp
ENSRNOP00055029517
resolver
ensp
ENSRNOP00060034910
resolver
ensp
ENSRNOP00065000527
resolver
ensp
ENSRNOP00065038023
resolver
enst
ENSRNOT00000074533
resolver
enst
ENSRNOT00055036325
resolver
enst
ENSRNOT00060042100
resolver
enst
ENSRNOT00065000603
resolver
enst
ENSRNOT00065046357
resolver
genesymbol
Ggt1
resolver
genesymbol_syn
Ggt
resolver
uniprot
Q63217
resolver
uniprot
Q63218
resolver
uniprot
Q6AZ32
resolver
uniprot_entry
GGT1_RAT
resolver
uniprot_sec
Q63217
resolver
uniprot_sec
Q63218
resolver
uniprot_sec
Q6AZ32
resolver
activity_regulation
ACTIVITY REGULATION: Activated by autocatalytic cleavage. {ECO:0000250|UniProtKB:P19440}.
uniprot
proteins
amino_acid_sequence
MKNRFLVLGLVAVVLVFVIIGLCIWLPTTSGKPDHVYSRAAVATDAKRCSEIGRDMLQEGGSVVDAAIASLLCMGLINAHSMGIGGGLFFTIYNSTTRKAEVINAREMAPRLANTSMFNNSKDSEEGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARHGFPVGKGLARALDKKRDIIEKTPALCEVFCRQGKVLQEGETVTMPKLADTLQILAQEGARAFYNGSLTAQIVKDIQEAGGIMTVEDLNNYRAEVIEHPMSIGLGDSTLYVPSAPLSGPVLILILNILKGYNFSPKSVATPEQKALTYHRIVEAFRFAYAKRTMLGDPKFVDVSQVIRNMSSEFYATQLRARITDETTHPTAYYEPEFYLPDDGGTAHLSVVSEDGSAVAATSTINLYFGSKVLSRVSGILFNDEMDDFSSPNFTNQFGVAPSPANFIKPGKQPLSSMCPSIIVDKDGKVRMVVGASGGTQITTSVALAIINSLWFGYDVKRAVEEPRLHNQLLPNTTTVEKNIDQVVTAGLKTRHHHTEVTPDFIAVVQAVVRTSGGWAAASDSRKGGEPAGY
uniprot
proteins
ec_number
2.3.2.2
uniprot
proteins
ec_number
3.4.19.13
uniprot
proteins
ec_number
3.4.19.14
uniprot
proteins
function
FUNCTION: Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4) (By similarity) (PubMed:6122208). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases (PubMed:6122208). In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:6122208). Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4 (PubMed:6122208). {ECO:0000250|UniProtKB:P19440, ECO:0000269|PubMed:6122208}.
uniprot
proteins
mass_dalton
61610
uniprot
proteins
pathway_participation
PATHWAY: Sulfur metabolism; glutathione metabolism. {ECO:0000305|PubMed:6122208}.; PATHWAY: Lipid metabolism; leukotriene D4 biosynthesis. {ECO:0000305|PubMed:6122208}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated on both chains; contains sialic acid residues. It is not known if the sialic acid residues are present on N-linked or on O-linked glycans. {ECO:0000269|PubMed:6142889}.; PTM: O-glycosylated; close to the membrane anchor on the heavy chain and on the light chain. The sugar moieties are localized to the stretch Thr-28 to Ser-30. Contains sialic acid residues. It is not known if the sialic acid residues are present on N-linked or on O-linked glycans. {ECO:0000269|PubMed:2573604}.; PTM: Cleaved by autocatalysis into a large and a small subunit and the autocatalytic cleavage is essential to the functional activation of the enzyme. {ECO:0000250|UniProtKB:P19440}.
uniprot
proteins
protein_family
Gamma-glutamyltransferase family
uniprot
proteins
pubmed
10392451
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1671556
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
2567622
uniprot
proteins
pubmed
2573604
uniprot
proteins
pubmed
2869471
uniprot
proteins
pubmed
2869484
uniprot
proteins
pubmed
2896486
uniprot
proteins
pubmed
2907498
uniprot
proteins
pubmed
6122208
uniprot
proteins
pubmed
6136502
uniprot
proteins
pubmed
6142889
uniprot
proteins
pubmed
7910821
uniprot
proteins
pubmed
8776
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P19440}; Single-pass type II membrane protein {ECO:0000305|PubMed:6136502}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..26; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000305|PubMed:6136502
uniprot
proteins