CLPTM1
entrez
1209
canonical
uniprot
O96005
canonical
ensembl
ENSG00000104853
resolver
ensp
ENSP00000336994
resolver
ensp
ENSP00000442011
resolver
ensp
ENSP00000443192
resolver
genesymbol
CLPTM1
resolver
hgnc
HGNC:2087
resolver
uniprot
A0A0S2Z3H2
resolver
uniprot
B3KQH2
resolver
uniprot
B4DDS3
resolver
uniprot
B4E2X9
resolver
uniprot
B7Z9X9
resolver
uniprot
F5H8J3
resolver
uniprot
Q53ET6
resolver
uniprot
Q9BSS5
resolver
uniprot_entry
A0A0S2Z3H2_HUMAN
resolver
uniprot_entry
CLPT1_HUMAN
resolver
uniprot_sec
B3KQH2
resolver
uniprot_sec
B4DDS3
resolver
uniprot_sec
B4E2X9
resolver
uniprot_sec
B7Z9X9
resolver
uniprot_sec
F5H8J3
resolver
uniprot_sec
Q53ET6
resolver
uniprot_sec
Q9BSS5
resolver
amino_acid_sequence
MAAAQEADGARSAVVAAGGGSSGQVTSNGSIGRDPPAETQPQNPPAQPAPNAWQVIKGVLFRIFIIWAISSWFRRGPAPQDQAGPGGAPRVASRNLFPKDTLMNLHVYISEHEHFTDFNATSALFWEQHDLVYGDWTSGENSDGCYEHFAELDIPQSVQQNGSIYIHVYFTKSGFHPDPRQKALYRRLATVHMSRMINKYKRRRFQKTKNLLTGETEADPEMIKRAEDYGPVEVISHWHPNITINIVDDHTPWVKGSVPPPLDQYVKFDAVSGDYYPIIYFNDYWNLQKDYYPINESLASLPLRVSFCPLSLWRWQLYAAQSTKSPWNFLGDELYEQSDEEQDSVKVALLETNPYLLALTIIVSIVHSVFEFLAFKNDIQFWNSRQSLEGLSVRSVFFGVFQSFVVLLYILDNETNFVVQVSVFIGVLIDLWKITKVMDVRLDREHRVAGIFPRLSFKDKSTYIESSTKVYDDMAFRYLSWILFPLLGCYAVYSLLYLEHKGWYSWVLSMLYGFLLTFGFITMTPQLFINYKLKSVAHLPWRMLTYKALNTFIDDLFAFVIKMPVMYRIGCLRDDVVFFIYLYQRWIYRVDPTRVNEFGMSGEDPTAAAPVAEVPTAAGALTPTPAPTTTTATREEASTSLPTKPTQGASSASEPQEAPPKPAEDKKKD
uniprot
proteins
function
FUNCTION: Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate (By similarity). Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity). Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states (PubMed:29255114). May play a role in T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8VBZ3, ECO:0000250|UniProtKB:Q96KA5, ECO:0000269|PubMed:29255114}.
uniprot
proteins
mass_dalton
76097
uniprot
proteins
protein_family
CLPTM1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16263699
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25489052
uniprot
proteins
pubmed
29255114
uniprot
proteins
pubmed
9828125
uniprot
proteins
sequence_length
669
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 355..375; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 391..411; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 417..437; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 478..498; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 503..523; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins