Gpr83
entrez
140595
canonical
uniprot
Q8VHD7
canonical
ensembl
ENSRNOG00000030318
resolver
ensembl
ENSRNOG00055006959
resolver
ensembl
ENSRNOG00060005568
resolver
ensembl
ENSRNOG00065012029
resolver
ensp
ENSRNOP00000043707
resolver
ensp
ENSRNOP00055009029
resolver
ensp
ENSRNOP00060006967
resolver
ensp
ENSRNOP00065015005
resolver
enst
ENSRNOT00000044945
resolver
enst
ENSRNOT00055011482
resolver
enst
ENSRNOT00060009262
resolver
enst
ENSRNOT00065019571
resolver
genesymbol
Gpr83
resolver
genesymbol_syn
Gir
resolver
uniprot_entry
GPR83_RAT
resolver
amino_acid_sequence
MNVPPVLLLFLLSSVRATEQPQVVTEHPSMDAALTGANASHFWANYTFSDWQNFVGRRRYGAESQNPTVKALLIVAYSFIIVFSLFGNVLVCHVIFKNQRMHSATSLFIVNLAVADIMITLLNTPFTLVRFVNSTWVFGKGMCHVSRFAQYCSLHVSALTLTAIAVDRHQVIMHPLKPRISITKGVIYIAVIWVMATFFSLPHAICQKLFTFKYSEDIVRSLCLPDFPEPADLFWKYLDLATFILLYLLPLFIISVAYARVAKKLWLCNTIGDVTTEQYLALRRKKKTTVKMLVLVVVLFALCWFPLNCYVLLLSSKAIHTNNALYFAFHWFAMSSTCYNPFIYCWLNENFRVELKALLSMCQRPSKPQEDRLPSPVPSFRVAWTEKSHGRRALLANHHLPSSQIQSGKTDLSSVEPTVAVS
uniprot
proteins
function
FUNCTION: G protein-coupled peptide receptor. Several peptides, PEN, derived from the proSAAS precursor (encoded by PCSK1N), the procholecystokinin-derived peptide proCCK56-63, and the related proteins FAM237A and FAM237B have been reported to activate GPR83 through GNAI1/G(i) and GNAS/G(s)-mediated signaling pathways. G protein-coupled peptide receptor (By similarity). However, due to conflicting evidence about the ability of these peptides to bind to and activate the GPR83, the endogenous ligand of GPR83 still remains uncertain. Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors (By similarity). {ECO:0000250|UniProtKB:P30731, ECO:0000250|UniProtKB:Q9NYM4}.
uniprot
proteins
mass_dalton
47957
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11698613
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17240481
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P30731}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with GPR171 in the paraventricular nucleus. Colocalizes with the ghrelin receptor GHSR1A in the hypothalamus. {ECO:0000250|UniProtKB:P30731}.
uniprot
proteins
transmembrane_region
TRANSMEM 71..91; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 107..127; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 144..166; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 185..205; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 237..257; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 293..313; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 327..347; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins