Ptprj
entrez
19271
canonical
uniprot
Q64455
canonical
ensembl
ENSMUSG00000025314
resolver
ensp
ENSMUSP00000107121
resolver
ensp
ENSMUSP00000129592
resolver
enst
ENSMUST00000111495
resolver
enst
ENSMUST00000168621
resolver
genesymbol
Ptprj
resolver
genesymbol_syn
Byp
resolver
genesymbol_syn
Scc1
resolver
uniprot
A2AWF9
resolver
uniprot
E9Q4S7
resolver
uniprot
Q3UH64
resolver
uniprot
Q3UHL5
resolver
uniprot
Q541R5
resolver
uniprot
Q8CIW9
resolver
uniprot
Q8K3Q2
resolver
uniprot_entry
A2AWF9_MOUSE
resolver
uniprot_entry
E9Q4S7_MOUSE
resolver
uniprot_entry
PTPRJ_MOUSE
resolver
uniprot_sec
Q3UH64
resolver
uniprot_sec
Q3UHL5
resolver
uniprot_sec
Q541R5
resolver
uniprot_sec
Q8CIW9
resolver
uniprot_sec
Q8K3Q2
resolver
amino_acid_sequence
MKPAARETRTPPRSPGLRWALLPLLLLLRQGQVLCAGAAPNPIFDIEAVVSPTSVLLTWKHNDSGASECRIENKMESNLTFPVKNQTSCNITGLSPGTSYTFSIISVTTNETLNKTITTEPWPVSDLHVTSVGVTQARLTWSNANGTASYRMLIEELTTHSSVNISGLKPGTNNSFAFPESNETQADFAVAEEVPDANGTKRIPVTNLSQLHKNSLVSVDPPSGQDPSLTEILLTDLKPDTQYNATIYSQAANGTEGQPRNKVFKTNSTQVSDVRAMNISASSMTLTWKSNYDGSRTSIVYKIHVAGGTHSVNQTVNKTEAIILGLSSSTLYNITVHPFLGQTEGTPGFLQVYTSPDQVSDFRVTNVSTRAIGLAWRSNDSKSFEIFIKQDGGEKHRNASTGNQSYMVEDLKPGTSYHFEIIPRGPDGTEGLSSTVNGSTDPSAVTDIRVVNISTTEMQLEWQNTDDASGYTYHLVLESKSGSIIRTNSSQKWITVGSLTPGTLYNVTIFPEVDQIQGISNSITQYTRPSSVSHIEVNTTTTTAAIRWKNEDAASASYAYSVLILKTGDGSNVTSNFTKDPSILIPELIPGVSYTVKILTQVGDGTTSLVPGWNLFCTEPEPVTSFHCEVVPKEPALVLKWACPFGMYTGFELGVRSDSWDNMTRLENCTSDDDTECRTEVAYLNFSTSYNISIATLSCGKMALPAQNICTTGITDPPTPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTTGEAAQPSADVLKYTYEDFKRGASDTYVTYLIRIEEKGQSQGLSEVLNYEIDVGNQSTTLGYYNGRLEPLGSYRACVAGFTNITYNLQNDGLINGDESYVSFSPYSEAVFLPQDPGVICGAVFGCIFGALAITAVGGFIFWRKKRTDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLIGISLPKYTAEIAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIVMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEVVLPEWTIRDFVVKNMQNSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQIPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIIRAQKDSKVDLIYQNTTAMTIYENLEPVSMFGKTNGYIA
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (By similarity). Plays a role in cell adhesion, migration, proliferation and differentiation (PubMed:18249142). Has a role in megakaryocytes and platelet formation. Involved in vascular development (PubMed:12588999). May be involved in the mechanism of contact inhibition of cell growth (PubMed:12771128). Regulator of macrophage adhesion and spreading (PubMed:19268662). Positively affects cell-matrix adhesion (PubMed:12833140). Positive regulator of platelet activation and thrombosis (PubMed:19246339). Negative regulator of cell proliferation (By similarity). Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR (PubMed:12833140). Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation (By similarity). Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation (By similarity). Enhances the barrier function of epithelial junctions during reassembly (By similarity). Negatively regulates T-cell receptor (TCR) signaling (By similarity). Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling (PubMed:12913111). {ECO:0000250|UniProtKB:Q12913, ECO:0000269|PubMed:12588999, ECO:0000269|PubMed:12771128, ECO:0000269|PubMed:12833140, ECO:0000269|PubMed:12913111, ECO:0000269|PubMed:18249142, ECO:0000269|PubMed:19246339, ECO:0000269|PubMed:19268662}.
uniprot
proteins
mass_dalton
136769
uniprot
proteins
mutagenesis
MUTAGEN 1106; /note="D->A: Substrate trapping with much higher affinity for substrate."; /evidence="ECO:0000269|PubMed:12771128"; MUTAGEN 1140; /note="C->S: Catalytically inactive and substrate trapping with higher affinity for substrate."; /evidence="ECO:0000269|PubMed:12771128, ECO:0000269|PubMed:12833140
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 3 subfamily
uniprot
proteins
pubmed
12089527
uniprot
proteins
pubmed
12588999
uniprot
proteins
pubmed
12771128
uniprot
proteins
pubmed
12833140
uniprot
proteins
pubmed
12913111
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18249142
uniprot
proteins
pubmed
19246339
uniprot
proteins
pubmed
19268662
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8483328
uniprot
proteins
pubmed
8549806
uniprot
proteins
pubmed
9823776
uniprot
proteins
sequence_length
1238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane. Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses. Found at cell borders.
uniprot
proteins
transmembrane_region
TRANSMEM 877..897; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins