SNRPD3
entrez
6634
canonical
uniprot
P62318
canonical
ensembl
ENSG00000100028
resolver
ensembl
ENSG00000286070
resolver
ensp
ENSP00000215829
resolver
ensp
ENSP00000535674
resolver
genesymbol
SNRPD3
resolver
hgnc
HGNC:11160
resolver
uniprot
B4DJP7
resolver
uniprot
B5BU13
resolver
uniprot
P43331
resolver
uniprot_entry
SMD3_HUMAN
resolver
uniprot_sec
B4DJP7
resolver
uniprot_sec
B5BU13
resolver
uniprot_sec
P43331
resolver
amino_acid_sequence
MSIGVPIKVLHEAEGHIVTCETNTGEVYRGKLIEAEDNMNCQMSNITVTYRDGRVAQLEQVYIRGSKIRFLILPDMLKNAPMLKSMKNKNQGSGAGRGKAAILKAQVAARGRGRGMGRGNIFQKRR
uniprot
proteins
function
FUNCTION: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). {ECO:0000250|UniProtKB:P62320, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932}.
uniprot
proteins
mass_dalton
13916
uniprot
proteins
post_translational_modification
PTM: Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs. {ECO:0000269|PubMed:11747828, ECO:0000269|PubMed:17709427}.
uniprot
proteins
protein_family
SnRNP core protein family
uniprot
proteins
pubmed
10025403
uniprot
proteins
pubmed
10500148
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11135666
uniprot
proteins
pubmed
11574479
uniprot
proteins
pubmed
11747828
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
12628254
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15146077
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16314521
uniprot
proteins
pubmed
17709427
uniprot
proteins
pubmed
18984161
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
19325628
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21516107
uniprot
proteins
pubmed
25555158
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26912367
uniprot
proteins
pubmed
28076346
uniprot
proteins
pubmed
28502770
uniprot
proteins
pubmed
28781166
uniprot
proteins
pubmed
32494006
uniprot
proteins
pubmed
33509932
uniprot
proteins
pubmed
36797247
uniprot
proteins
pubmed
7527560
uniprot
proteins
sequence_length
126
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.
uniprot
proteins