Dll3
entrez
13389
canonical
uniprot
O88516
canonical
ensembl
ENSMUSG00000003436
resolver
ensp
ENSMUSP00000103951
resolver
genesymbol
Dll3
resolver
uniprot
O35675
resolver
uniprot
Q3UND5
resolver
uniprot
Q80W06
resolver
uniprot
Q9QWL9
resolver
uniprot
Q9QWZ7
resolver
uniprot_entry
DLL3_MOUSE
resolver
uniprot_entry
Q3UND5_MOUSE
resolver
uniprot_sec
O35675
resolver
uniprot_sec
Q80W06
resolver
uniprot_sec
Q9QWL9
resolver
uniprot_sec
Q9QWZ7
resolver
amino_acid_sequence
MVSLQVSPLSQTLILAFLLPQALPAGVFELQIHSFGPGPGLGTPRSPCNARGPCRLFFRVCLKPGVSQEATESLCALGAALSTSVPVYTEHPGESAAALPLPDGLVRVPFRDAWPGTFSLVIETWREQLGEHAGGPAWNLLARVVGRRRLAAGGPWARDVQRTGTWELHFSYRARCEPPAVGAACARLCRSRSAPSRCGPGLRPCTPFPDECEAPSVCRPGCSPEHGYCEEPDECRCLEGWTGPLCTVPVSTSSCLNSRVPGPASTGCLLPGPGPCDGNPCANGGSCSETSGSFECACPRGFYGLRCEVSGVTCADGPCFNGGLCVGGEDPDSAYVCHCPPGFQGSNCEKRVDRCSLQPCQNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGSRRCSCALGFGGRDCRERADPCASRPCAHGGRCYAHFSGLVCACAPGYMGVRCEFAVRPDGADAVPAAPRGLRQADPQRFLLPPALGLLVAAGLAGAALLVIHVRRRGPGQDTGTRLLSGTREPSVHTLPDALNNLRLQDGAGDGPSSSADWNHPEDGDSRSIYVIPAPSIYAREDWLIQVLF
uniprot
proteins
disease_involvement
DISEASE: Note=A truncating mutation in Dll3 is the cause of the pudgy (pu) phenotype. Pudgy mice exhibit patterning defects at the earliest stages of somitogenesis. Adult pudgy mice present severe vertebral and rib deformities. {ECO:0000269|PubMed:9662403}.
uniprot
proteins
function
FUNCTION: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
uniprot
proteins
mass_dalton
62069
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9272948
uniprot
proteins
pubmed
9662403
uniprot
proteins
sequence_length
592
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 491..511; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins