Sstr2
entrez
54305
canonical
uniprot
P30680
canonical
ensembl
ENSRNOG00000002793
resolver
ensembl
ENSRNOG00055032775
resolver
ensembl
ENSRNOG00060023021
resolver
ensembl
ENSRNOG00065019192
resolver
ensp
ENSRNOP00000110504
resolver
genesymbol
Sstr2
resolver
uniprot_entry
SSR2_RAT
resolver
amino_acid_sequence
MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
uniprot
proteins
function
FUNCTION: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. {ECO:0000269|PubMed:11134004, ECO:0000269|PubMed:17981995, ECO:0000269|PubMed:19434240, ECO:0000269|PubMed:8386508}.
uniprot
proteins
mass_dalton
41200
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization. {ECO:0000269|PubMed:17981995, ECO:0000269|PubMed:19389921}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11134004
uniprot
proteins
pubmed
1348934
uniprot
proteins
pubmed
1374909
uniprot
proteins
pubmed
17981995
uniprot
proteins
pubmed
19389921
uniprot
proteins
pubmed
19434240
uniprot
proteins
pubmed
8386508
uniprot
proteins
sequence_length
369
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
uniprot
proteins
transmembrane_region
TRANSMEM 44..67; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 79..103; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 119..138; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 162..181; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 208..229; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 254..278; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 289..303; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins