Cd244
entrez
64025
canonical
uniprot
Q9JLM2
canonical
ensembl
ENSRNOG00000068754
resolver
ensp
ENSRNOP00000100801
resolver
enst
ENSRNOT00000152303
resolver
genesymbol
Cd244
resolver
genesymbol
Cd244l1
resolver
genesymbol_syn
2b4
resolver
genesymbol_syn
Nmrk
resolver
uniprot
A0ABK0LDB6
resolver
uniprot
Q9JLM3
resolver
uniprot_entry
A0ABK0LDB6_RAT
resolver
uniprot_entry
CD244_RAT
resolver
uniprot_sec
Q9JLM3
resolver
amino_acid_sequence
MLQQTVLLSLFLLLRAHQGQDCADSSEEVLGVSGKPVRLRPSNIQAKHVSIEWKKKTGHQQTPQIVTWDTTDNKNFNMCCSDIYGFESENFALSIKSAKLNDSGHYLLEITNQRGIVCTKNFQMLIFDPVETPHLTVQGTLWANGTCQLSLSCFVPKDDNVSYALYRGSMLISNQRYGTHWENRTDASSLHTYTCNVSNKASWANHTLTSPQSCQSVPSKFNYLPFMVSIGILVKFFHGAIDCFCVWNRKRKQSQSIAKESLTIHEYVKNAQVSRDQRGHFRASGSSSDVRGDERGQRESDRRLFQFINRS
uniprot
proteins
function
FUNCTION: Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor. Activating function implicates association with SH2D1A and FYN. Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2. Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (By similarity). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1. At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (By similarity). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD48 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity). {ECO:0000250|UniProtKB:Q07763, ECO:0000250|UniProtKB:Q9BZW8}.
uniprot
proteins
mass_dalton
35300
uniprot
proteins
post_translational_modification
PTM: N-linked glycosylation is essential for the binding to its ligand CD48. Also O-glycosylated, in contrast, O-linked sialylation has a negative impact on ligand binding. {ECO:0000250|UniProtKB:Q9BZW8}.; PTM: Phosphorylated by FYN and CSK on tyrosine residues following activation. Coligation with inhibitory receptors such as KIR2DL1 inhibits phosphorylation upon contact of NK cells with sensitive target cells. {ECO:0000250|UniProtKB:Q9BZW8}.
uniprot
proteins
pubmed
10803843
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9BZW8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9BZW8}. Cell membrane {ECO:0000250|UniProtKB:Q9BZW8}. Membrane raft {ECO:0000250|UniProtKB:Q9BZW8}. Note=Receptor engagement results in a recruitment to lipid drafts essential for the subsequent tyrosine phosphorylation of the ITSMs. {ECO:0000250|UniProtKB:Q9BZW8}.
uniprot
proteins
transmembrane_region
TRANSMEM 224..247; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins