SMPDL3B
entrez
27293
canonical
uniprot
Q92485
canonical
ensembl
ENSG00000130768
resolver
ensp
ENSP00000362995
resolver
ensp
ENSP00000363001
resolver
ensp
ENSP00000587848
resolver
genesymbol
SMPDL3B
resolver
genesymbol_syn
ASML3B
resolver
genesymbol_syn
ASMLPD
resolver
hgnc
HGNC:21416
resolver
uniprot
B4DEC6
resolver
uniprot
B4DW34
resolver
uniprot
B7ZB35
resolver
uniprot
Q5T0Z0
resolver
uniprot
Q96CB7
resolver
uniprot_entry
ASM3B_HUMAN
resolver
uniprot_entry
B4DEC6_HUMAN
resolver
uniprot_entry
B4DW34_HUMAN
resolver
uniprot_sec
B7ZB35
resolver
uniprot_sec
Q5T0Z0
resolver
uniprot_sec
Q96CB7
resolver
amino_acid_sequence
MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQGTPRWELEYQLTEAYGVPDASAHSMHTVLDRIAGDQSTLQRYYVYNSVSYSAGVCDEACSMQHVCAMRQVDIDAYTTCLYASGTTPVPQLPLLLMALLGLCTLVL
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
function
FUNCTION: Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358). Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity). {ECO:0000250|UniProtKB:P58242, ECO:0000269|PubMed:26095358}.
uniprot
proteins
mass_dalton
50814
uniprot
proteins
mutagenesis
MUTAGEN 135; /note="H->A: Reduced phosphodiesterase activity."; /evidence="ECO:0000269|PubMed:26095358
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:26095358}.
uniprot
proteins
protein_family
Acid sphingomyelinase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
26095358
uniprot
proteins
sequence_length
455
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:P58242}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P58242}.
uniprot
proteins