DGKB
entrez
1607
canonical
uniprot
Q9Y6T7
canonical
ensembl
ENSG00000136267
resolver
ensp
ENSP00000382260
resolver
ensp
ENSP00000384909
resolver
ensp
ENSP00000385031
resolver
ensp
ENSP00000385780
resolver
ensp
ENSP00000386066
resolver
ensp
ENSP00000580887
resolver
ensp
ENSP00000580888
resolver
ensp
ENSP00000580889
resolver
ensp
ENSP00000580890
resolver
ensp
ENSP00000580892
resolver
ensp
ENSP00000580893
resolver
ensp
ENSP00000637786
resolver
ensp
ENSP00000637788
resolver
enst
ENST00000402815
resolver
enst
ENST00000407950
resolver
enst
ENST00000910829
resolver
enst
ENST00000967727
resolver
genesymbol
DGKB
resolver
genesymbol_syn
DAGK2
resolver
genesymbol_syn
KIAA0718
resolver
hgnc
HGNC:2850
resolver
uniprot
A4D116
resolver
uniprot
A4D117
resolver
uniprot
A8MXU2
resolver
uniprot
B5MBY2
resolver
uniprot
B5MCD5
resolver
uniprot
B5MDK1
resolver
uniprot
O75241
resolver
uniprot
Q2M377
resolver
uniprot
Q75MF9
resolver
uniprot
Q75MU7
resolver
uniprot
Q86UI5
resolver
uniprot
Q86UM9
resolver
uniprot
Q9UQ29
resolver
uniprot_entry
B5MBY2_HUMAN
resolver
uniprot_entry
B5MCD5_HUMAN
resolver
uniprot_entry
DGKB_HUMAN
resolver
uniprot_sec
A4D116
resolver
uniprot_sec
A4D117
resolver
uniprot_sec
A8MXU2
resolver
uniprot_sec
B5MDK1
resolver
uniprot_sec
O75241
resolver
uniprot_sec
Q2M377
resolver
uniprot_sec
Q75MF9
resolver
uniprot_sec
Q75MU7
resolver
uniprot_sec
Q86UI5
resolver
uniprot_sec
Q86UM9
resolver
uniprot_sec
Q9UQ29
resolver
activity_regulation
ACTIVITY REGULATION: Activated by calcium. {ECO:0000250|UniProtKB:P49621}.
uniprot
proteins
amino_acid_sequence
MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPRTTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFCSLVKRTRNRSKE
uniprot
proteins
ec_number
2.7.1.107
uniprot
proteins
function
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity). {ECO:0000250|UniProtKB:P49621, ECO:0000250|UniProtKB:Q6NS52, ECO:0000269|PubMed:11719522, ECO:0000305}.; FUNCTION: [Isoform 2]: Does not associate with membranes but has a diacylglycerol kinase activity. {ECO:0000269|PubMed:11719522}.
uniprot
proteins
mass_dalton
90595
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000305|PubMed:11719522}.
uniprot
proteins
protein_family
Eukaryotic diacylglycerol kinase family
uniprot
proteins
pubmed
11719522
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
804
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q6NS52}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NS52}. Cell membrane {ECO:0000269|PubMed:11719522}; Peripheral membrane protein {ECO:0000305|PubMed:11719522}. Cytoplasm {ECO:0000269|PubMed:11719522}. Note=Translocation to the plasma membrane is induced by phorbol esters. {ECO:0000269|PubMed:11719522}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:11719522}.
uniprot
proteins