PSMC4
entrez
5704
canonical
uniprot
P43686
canonical
ensembl
ENSG00000013275
resolver
ensembl
ENSG00000281221
resolver
ensp
ENSP00000157812
resolver
ensp
ENSP00000413869
resolver
genesymbol
PSMC4
resolver
genesymbol_syn
MIP224
resolver
genesymbol_syn
TBP7
resolver
hgnc
HGNC:9551
resolver
uniprot
A8K2M0
resolver
uniprot
Q96FV5
resolver
uniprot
Q9UBM3
resolver
uniprot
Q9UEX3
resolver
uniprot_entry
A8K2M0_HUMAN
resolver
uniprot_entry
PRS6B_HUMAN
resolver
uniprot_sec
Q96FV5
resolver
uniprot_sec
Q9UBM3
resolver
uniprot_sec
Q9UEX3
resolver
amino_acid_sequence
MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:8060531}.
uniprot
proteins
mass_dalton
47366
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
1317798
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15831487
uniprot
proteins
pubmed
17292836
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22078707
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
29804830
uniprot
proteins
pubmed
8060531
uniprot
proteins
pubmed
8419915
uniprot
proteins
pubmed
8603043
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
uniprot
proteins