Lifr
entrez
81680
canonical
uniprot
O70535
canonical
ensembl
ENSRNOG00000011696
resolver
ensp
ENSRNOP00000016036
resolver
enst
ENSRNOT00000016036
resolver
genesymbol
Lifr
resolver
uniprot
G3V7K2
resolver
uniprot_entry
G3V7K2_RAT
resolver
uniprot_entry
LIFR_RAT
resolver
amino_acid_sequence
MGAFSWWRQPSWMADNKRGRMTPSLPWLLSALTLLHLMMHVNGLKRGVQQDLKCTTNNMRVWDCSWPAPLGVSPGTVKDICIKDRPHSCHRLETTNVKIPALSPGDHEVTINYQNGFQSKFTLNEKDVSLVPDTPEILSLSADFSTSTLQLKWNDKGSALPYPSNATWEVKVLQNPRTEPVALVSLNTVLSGKDKGHHWNWTSELPLQCATHSVSIRWHIDYPRFSGYKEWSEWSPLKNISWTRNTETNVFPQDKVVLAGSNMTICCISTTKVLSGQIGNTFRPLIHLYGETVAINILNIPVSENSGSNVIFSTVDDVYGTVVFAGYPPDVPQKLSCETHDLKEIICSWNPGRITGLVGPRNTEYTLFESISGKSAVFHRFEELANETYWLTLKMAPDQEIHNFTLTARNPLGQTESAIVINATERVALHVPISLKVKDVNSTVVTLSWYLPGNFTKINLVCQIEICKANSKKEVRNVTMRGAEDSTYHVAVDKLNPYTIYTFRVRCSSETFWKWSKWSNEKRYLTTEATPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSSEETQSLSEILDPQHKAEIKVNKNDYIISVVARNSAGSSPPSKIASMEIPNDDITVEQAVGIGNRIFLSWQHNPNMTCDYVIKWCNSSWSEPCLLDWIKVPSNSTGTVIESDQFQPGVRYNFYLYGCTNQGYQLLRSTIGYIEELAPIVAPNFTVEDTSADSILVKWDDIPVEELRGFLRGYLFYFQKGERDTPKTRSLETSHSDIKLKNITDISQKTLRIADLQGKTSYHLVLRAYTHGGLGPEKSMFVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSNALKTLEMNPCTPNHVEVLESRSIPPKIEDTEITSPVSERPGESSETDPENQAAVSYCPPIIEEEITNPAADEAGGASQVVYIDVQSMYQPQAKAEDEQDTDPVMVAGYKPQMRLPINPTAEDTTAEDEADKTAGYRPQANVNTWNLVSPDSPRSTDSNSEVVSFGSPCSINSRQFLIPPKDEDSPKSNGGGWSFTNFFQNKPND
uniprot
proteins
function
FUNCTION: Functions as a signal-transducing subunit either in complex with IL6ST/gp130 or as part of the ciliary neurotrophic factor receptor (CNTFR) complex composed by CNTFR, IL6ST/gp130 and LIFR. Signal transmission is initiated either by binding directly to cytokines, such as OSM or LIF, or through the binding of other cytokines, like CNTF, CLCF1 or the heterodimeric complex CRLF1-CLCF1 to the non-signaling receptor CNTFR; ligand binding induces heterodimerization of IL6ST/gp130 and LIFR which activates JAK tyrosine kinases bound to their intracellular domains. These kinases subsequently phosphorylate the homodimer or heterodimer form of IL6ST/gp130. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STATs). Engages sites 3 of ligands cytokines. {ECO:0000250|UniProtKB:P42702}.
uniprot
proteins
mass_dalton
122394
uniprot
proteins
protein_family
Type 2 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
9349722
uniprot
proteins
sequence_length
1093
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P42702}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P42702}.
uniprot
proteins
transmembrane_region
TRANSMEM 830..850; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins