Pcbd1
entrez
29700
canonical
uniprot
P61459
canonical
ensembl
ENSRNOG00000000566
resolver
ensembl
ENSRNOG00055009218
resolver
ensembl
ENSRNOG00055009225
resolver
ensembl
ENSRNOG00060002847
resolver
ensembl
ENSRNOG00060002857
resolver
ensembl
ENSRNOG00065022667
resolver
ensembl
ENSRNOG00065022728
resolver
ensp
ENSRNOP00000100247
resolver
ensp
ENSRNOP00055012513
resolver
ensp
ENSRNOP00055012548
resolver
ensp
ENSRNOP00060003276
resolver
ensp
ENSRNOP00060003291
resolver
ensp
ENSRNOP00065031407
resolver
ensp
ENSRNOP00065031512
resolver
enst
ENSRNOT00000130263
resolver
enst
ENSRNOT00055015598
resolver
enst
ENSRNOT00055015634
resolver
enst
ENSRNOT00060004600
resolver
enst
ENSRNOT00060004617
resolver
enst
ENSRNOT00065038716
resolver
enst
ENSRNOT00065038852
resolver
genesymbol
Pcbd1
resolver
genesymbol_syn
Dcoh
resolver
genesymbol_syn
Pcbd
resolver
uniprot
P70519
resolver
uniprot
P80095
resolver
uniprot
Q9D930
resolver
uniprot_entry
PHS_RAT
resolver
uniprot_sec
P70519
resolver
uniprot_sec
P80095
resolver
uniprot_sec
Q9D930
resolver
amino_acid_sequence
MAGKAHRLSAEERDQLLPNLRAVGWNELEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKLDHHPEWFNVYNKVHITLSTHECAGLSERDINLASFIEQVAVSMT
uniprot
proteins
ec_number
4.2.1.96
uniprot
proteins
function
FUNCTION: Involved in tetrahydrobiopterin biosynthesis (PubMed:8444860, PubMed:8618906). Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (PubMed:8444860). Coactivator for HNF1A-dependent transcription (PubMed:1763325). Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (PubMed:1763325). Also acts as a coactivator for HNF1B-dependent transcription (By similarity). {ECO:0000250|UniProtKB:P61457, ECO:0000269|PubMed:1763325, ECO:0000269|PubMed:8444860, ECO:0000269|PubMed:8618906}.
uniprot
proteins
mass_dalton
12000
uniprot
proteins
mutagenesis
MUTAGEN 82; /note="C->R: Reduced dehydratase activity. No impact on hydroxytetrahydrobiopterin-binding."; /evidence="ECO:0000269|PubMed:8618906
uniprot
proteins
protein_family
Pterin-4-alpha-carbinolamine dehydratase family
uniprot
proteins
pubmed
10966642
uniprot
proteins
pubmed
1465414
uniprot
proteins
pubmed
1763325
uniprot
proteins
pubmed
7744010
uniprot
proteins
pubmed
8444860
uniprot
proteins
pubmed
8618906
uniprot
proteins
pubmed
8897596
uniprot
proteins
pubmed
9865610
uniprot
proteins
sequence_length
104
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8444860}. Nucleus {ECO:0000269|PubMed:8444860}. Note=Recruited to the nucleus through the interaction with HNF1B. {ECO:0000250|UniProtKB:P35680}.
uniprot
proteins