Clic1
entrez
406864
canonical
uniprot
Q6MG61
canonical
ensembl
ENSRNOG00000029682
resolver
ensembl
ENSRNOG00055007230
resolver
ensembl
ENSRNOG00060004384
resolver
ensembl
ENSRNOG00065032148
resolver
ensp
ENSRNOP00000098091
resolver
ensp
ENSRNOP00055009546
resolver
ensp
ENSRNOP00060005612
resolver
ensp
ENSRNOP00065045579
resolver
enst
ENSRNOT00000120409
resolver
enst
ENSRNOT00055012043
resolver
enst
ENSRNOT00060007402
resolver
enst
ENSRNOT00065055406
resolver
genesymbol
Clic1
resolver
uniprot_entry
CLIC1_RAT
resolver
amino_acid_sequence
MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTSGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGISQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVARALK
uniprot
proteins
ec_number
1.8.-.-
uniprot
proteins
ec_number
1.8.5.1
uniprot
proteins
function
FUNCTION: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (By similarity). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle (By similarity). {ECO:0000250|UniProtKB:O00299}.
uniprot
proteins
mass_dalton
26981
uniprot
proteins
protein_family
Chloride channel CLIC family
uniprot
proteins
pubmed
15060004
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
26777142
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O00299}. Nucleus membrane {ECO:0000250|UniProtKB:O00299}; Single-pass membrane protein {ECO:0000250|UniProtKB:O00299}. Cytoplasm {ECO:0000250|UniProtKB:O00299}. Cell membrane {ECO:0000250|UniProtKB:O00299}; Single-pass membrane protein {ECO:0000250|UniProtKB:O00299}. Endoplasmic reticulum {ECO:0000269|PubMed:26777142}. Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Might not be present in the nucleus of cardiac cells. {ECO:0000250|UniProtKB:O00299, ECO:0000269|PubMed:26777142}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical; Note=After insertion into the membrane"; /evidence="ECO:0000255
uniprot
proteins