Q9JJI5
uniprot
Q9JJI5
canonical
amino_acid_sequence
MTPPCLNCSFFPGQLSPNASTGLLSCNDSEFKEHFDLEDLNLTHEDLRLKYLGPQQVKQFLPICVTYLLIFVVGTLGNGLTCTVILRQKAMHTPTNFYLFSLAVSDLLVLLVGLPLELYEMQHNYPFQLGAGGCYFRILLLETVCLASVLNVTALSVERYVAVVHPLQAKSVMTRTHVRRMLGAIWVFAILFSLPNTSLHGLSPLYVPCRGPVPDSVTCTLVRPQFFYKLVIQTTILLFFCLPMVTISVLYLLIGLRLRRERILLQEEVKGRISAAARQASHRSIQLRDRERRQVTKMLIALVIVFGTCWVPFHADRLMWSMVSHWTDGLRLAFQSVHLASGVFLYLGSAANPVLYNLMSTRFRESFRETLGLGTRCCHRHQPRHDSHSHLRLTTVSTLCDRNSRDVPLAENRDPGCEQETDPPE
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for the neuropeptides neuromedin-U (NMU) and neuromedin-S (NMS) (PubMed:10783389). Functionally, is involved in regulation of feeding and energy balance (PubMed:10894543). Additionally modulates blood pressure, smooth muscle contraction, hormone release and inflammatory responses in a tissue- and receptor-dependent manner (By similarity). Mechanistically, upon ligand binding, couples to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits. GNAQ/Gaq or GNA11/Ga11 coupling activatse a phospholipase C (PLC), hydrolyzing PIP2 (phosphatidylinositol 4,5-bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate) and mobilizing intracellular calcium via IP3 receptors on the endoplasmic reticulum. Also couples to GNAI1/Gai to inhibit forskolin-stimulated cAMP accumulation (By similarity). In pancreatic beta cells, through neuromedin U-25, regulates insulin secretion where it coupled to GNAI2 and GNAO1, resulting in reduced intracellular Ca2+ influx and cAMP levels. Through neuromedin U-25 in Th2-type T cells, enhances type 2 cytokine secretion and modulates inflammatory responses via activation of PLC-calcineurin-MEK and PI3K signaling pathways (By similarity). {ECO:0000250|UniProtKB:O55040, ECO:0000250|UniProtKB:P12760, ECO:0000250|UniProtKB:Q9HB89, ECO:0000269|PubMed:10783389, ECO:0000269|PubMed:10894543}.
uniprot
proteins
mass_dalton
48129
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10783389
uniprot
proteins
pubmed
10894543
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9HB89}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9HB89}.
uniprot
proteins
transmembrane_region
TRANSMEM 66..86; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9HB89"; TRANSMEM 98..118; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9HB89"; TRANSMEM 139..161; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9HB89"; TRANSMEM 182..202; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9HB89"; TRANSMEM 236..256; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9HB89"; TRANSMEM 295..315; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9HB89"; TRANSMEM 339..359; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9HB89
uniprot
proteins