O75920
uniprot
O75920
canonical
amino_acid_sequence
MARGNQRELARQKNMKKTQEISKGKRKEDSLTASQRKQSSGGQKSESKMSAGPHLPLKAPRENPCFPLPAAGGSRYYLAYGSITPISAFVFVVFFSVFFPSFYEDFCCWI
uniprot
proteins
function
FUNCTION: Positive regulator of amyloid protein aggregation and proteotoxicity (PubMed:20723760, PubMed:22854022, PubMed:31034892). Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates (PubMed:20723760, PubMed:22854022, PubMed:31034892). {ECO:0000269|PubMed:20723760, ECO:0000269|PubMed:22854022, ECO:0000269|PubMed:31034892}.
uniprot
proteins
mass_dalton
12349
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="R->A: No effect on SNCA binding."; /evidence="ECO:0000269|PubMed:31034892"; MUTAGEN 11; /note="R->E: Decreases SNCA binding."; /evidence="ECO:0000269|PubMed:31034892"; MUTAGEN 12; /note="Q->A: Slightly decreases SNCA binding."; /evidence="ECO:0000269|PubMed:31034892"; MUTAGEN 13; /note="K->A: Decreases SNCA binding."; /evidence="ECO:0000269|PubMed:31034892"; MUTAGEN 13; /note="K->E: Inhibits SNCA binding."; /evidence="ECO:0000269|PubMed:31034892"; MUTAGEN 14; /note="N->A: Decreases SNCA binding."; /evidence="ECO:0000269|PubMed:31034892"; MUTAGEN 16; /note="K->A: Drastically decreases SNCA binding."; /evidence="ECO:0000269|PubMed:31034892"; MUTAGEN 16; /note="K->E: Inhibits SNCA binding."; /evidence="ECO:0000269|PubMed:31034892"; MUTAGEN 17; /note="K->A: Drastically decreases SNCA binding."; /evidence="ECO:0000269|PubMed:31034892"; MUTAGEN 17; /note="K->E: Inhibits SNCA binding."; /evidence="ECO:0000269|PubMed:31034892"; MUTAGEN 18; /note="T->A: No effect on SNCA binding."; /evidence="ECO:0000269|PubMed:31034892
uniprot
proteins
protein_family
SERF family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20723760
uniprot
proteins
pubmed
22854022
uniprot
proteins
pubmed
31034892
uniprot
proteins
pubmed
9731538
uniprot
proteins
sequence_length
110
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:31034892}. Nucleus {ECO:0000269|PubMed:31034892}.
uniprot
proteins