Tpm4
entrez
326618
canonical
uniprot
Q6IRU2
canonical
ensembl
ENSMUSG00000031799
resolver
ensp
ENSMUSP00000003575
resolver
enst
ENSMUST00000003575
resolver
genesymbol
Tpm4
resolver
uniprot_entry
TPM4_MOUSE
resolver
amino_acid_sequence
MAGLNSLEAVKRKIQALQQQADDAEDRAQGLQRELDGERERREKAEGDAAALNRRIQLLEEELDRAQEQLATALQNLEEAEKAADESERGMKVIENRAMKDEEKMEILEMQLKEAKHITDEADRKYEEVARKLVILEGELKRAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVSKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI
uniprot
proteins
function
FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium (By similarity). Plays a role in platelet biogenesis (PubMed:28134622). {ECO:0000250|UniProtKB:P09495, ECO:0000250|UniProtKB:P67936, ECO:0000269|PubMed:28134622}.
uniprot
proteins
mass_dalton
28468
uniprot
proteins
protein_family
Tropomyosin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28134622
uniprot
proteins
sequence_length
248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P09495}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P09495}.
uniprot
proteins