Tmem65
entrez
74868
canonical
uniprot
Q4VAE3
canonical
ensembl
ENSMUSG00000062373
resolver
ensp
ENSMUSP00000071984
resolver
ensp
ENSMUSP00000218462
resolver
ensp
ENSMUSP00000327948
resolver
enst
ENSMUST00000072113
resolver
genesymbol
Tmem65
resolver
uniprot
Q810S8
resolver
uniprot_entry
TMM65_MOUSE
resolver
uniprot_sec
Q810S8
resolver
amino_acid_sequence
MSRLLPLLGSRTARSLRPGPAAAPRLPSWCCCGRGLLALGVPGGPRLLGTHPKKEPMEALNTAQGARDFIYSLHSTERSCLLKELHRFESIAIAQEKLEALPPTPGQLRYVFFHNAIPFVGFGFLDNAIMIVAGTQIELSIGIILGISTMAAAALGNLVSDLAGLGLAGYVEALASRLGLSIPDLTPKQVDMWQTRVSTHLGKAVGVTIGCILGMFPLIFFGGSEEDEKLETTN
uniprot
proteins
function
FUNCTION: Mitochondrial protein that plays a critical role in the sodium-dependent calcium efflux from mitochondrion (PubMed:40200126). The precise role of TMEM65 in mitochondrial sodium/calcium exchange is however unclear: TMEM65 associates with the SLC8B1/NCLX antiporter and probably promotes the sodium/calcium exchange mediated by SLC8B1/NCLX (By similarity). According to another report, TMEM65 functions as the mitochondrial sodium/calcium antiporter itself: homodimerization drives formation of a pocket capable of binding calcium (By similarity). Essential for maintaining proper cardiac intercalated disk (ICD) structure and function as well as cardiac conduction velocity in the heart (PubMed:36257954). Its association with SCN1B is required for stabilizing the perinexus in the ICD and for localization of GJA1 and SCN5A to the ICD (PubMed:26403541, PubMed:36257954). {ECO:0000250|UniProtKB:Q6PI78, ECO:0000269|PubMed:26403541, ECO:0000269|PubMed:36257954, ECO:0000269|PubMed:40200126}.
uniprot
proteins
mass_dalton
24918
uniprot
proteins
protein_family
TMEM65 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26403541
uniprot
proteins
pubmed
36257954
uniprot
proteins
pubmed
40200126
uniprot
proteins
sequence_length
234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q6PI78}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:26403541}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes at the intercalated disk in ventricular tissue and cardiomyocytes. {ECO:0000269|PubMed:26403541}.
uniprot
proteins
transmembrane_region
TRANSMEM 111..131; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins