Eif1a
entrez
317163
canonical
uniprot
Q6VV72
canonical
ensembl
ENSRNOG00000031421
resolver
ensembl
ENSRNOG00055018068
resolver
ensembl
ENSRNOG00060011284
resolver
ensembl
ENSRNOG00065019356
resolver
ensp
ENSRNOP00000046345
resolver
ensp
ENSRNOP00000069410
resolver
ensp
ENSRNOP00000092892
resolver
ensp
ENSRNOP00000094920
resolver
ensp
ENSRNOP00000099297
resolver
ensp
ENSRNOP00000102515
resolver
ensp
ENSRNOP00055024684
resolver
ensp
ENSRNOP00055024687
resolver
ensp
ENSRNOP00055024690
resolver
ensp
ENSRNOP00060014898
resolver
ensp
ENSRNOP00060014902
resolver
ensp
ENSRNOP00060014906
resolver
ensp
ENSRNOP00065026023
resolver
ensp
ENSRNOP00065026029
resolver
ensp
ENSRNOP00065026031
resolver
enst
ENSRNOT00000041237
resolver
enst
ENSRNOT00000087984
resolver
enst
ENSRNOT00000099432
resolver
enst
ENSRNOT00000099676
resolver
enst
ENSRNOT00000121417
resolver
enst
ENSRNOT00000160045
resolver
enst
ENSRNOT00055030642
resolver
enst
ENSRNOT00055030687
resolver
enst
ENSRNOT00055030692
resolver
enst
ENSRNOT00060019076
resolver
enst
ENSRNOT00060019080
resolver
enst
ENSRNOT00060019084
resolver
enst
ENSRNOT00065032598
resolver
enst
ENSRNOT00065032604
resolver
enst
ENSRNOT00065032606
resolver
genesymbol
Eif1a
resolver
genesymbol_syn
Eif1ax
resolver
uniprot
Q566D5
resolver
uniprot_entry
IF1A_RAT
resolver
uniprot_entry
Q566D5_RAT
resolver
amino_acid_sequence
MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVRRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQFDDIGDDDEDIDDI
uniprot
proteins
function
FUNCTION: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. {ECO:0000250|UniProtKB:P47813}.
uniprot
proteins
mass_dalton
16502
uniprot
proteins
protein_family
EIF-1A family
uniprot
proteins
sequence_length
144
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins