TNFSF12
entrez
8742
canonical
uniprot
O43508
canonical
ensembl
ENSG00000239697
resolver
ensembl
ENSG00000248871
resolver
ensp
ENSP00000293825
resolver
genesymbol
TNFSF12
resolver
genesymbol_syn
APO3L
resolver
genesymbol_syn
DR3LG
resolver
hgnc
HGNC:11927
resolver
uniprot
Q4ACW9
resolver
uniprot
Q8IZK7
resolver
uniprot
Q8WUZ7
resolver
uniprot_entry
Q4ACW9_HUMAN
resolver
uniprot_entry
TNF12_HUMAN
resolver
uniprot_sec
Q8IZK7
resolver
uniprot_sec
Q8WUZ7
resolver
amino_acid_sequence
MAARRSQRRRGRRGEPGTALLVPLALGLGLALACLGLLLAVVSLGSRASLSAQEPAQEELVAEEDQDPSELNPQTEESQDPAPFLNRLVRPRRSAPKGRKTRARRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYCQVHFDEGKAVYLKLDLLVDGVLALRCLEEFSATAASSLGPQLRLCQVSGLLALRPGSSLRIRTLPWAHLKAAPFLTYFGLFQVH
uniprot
proteins
function
FUNCTION: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. {ECO:0000269|PubMed:10085077, ECO:0000269|PubMed:23667509}.
uniprot
proteins
mass_dalton
27216
uniprot
proteins
post_translational_modification
PTM: The soluble form derives from the membrane form by proteolytic processing.
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
10085077
uniprot
proteins
pubmed
12411489
uniprot
proteins
pubmed
12787562
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14961121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
23667509
uniprot
proteins
pubmed
9405449
uniprot
proteins
pubmed
9560343
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12411489}; Single-pass type II membrane protein {ECO:0000269|PubMed:12411489}.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 12, secreted form]: Secreted.; SUBCELLULAR LOCATION: [Isoform TWE-PRIL]: Cell membrane; Single-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins