TMT1A
entrez
25840
canonical
uniprot
Q9H8H3
canonical
ensembl
ENSG00000185432
resolver
ensp
ENSP00000331787
resolver
ensp
ENSP00000447542
resolver
ensp
ENSP00000448286
resolver
ensp
ENSP00000448785
resolver
ensp
ENSP00000619739
resolver
enst
ENST00000332160
resolver
enst
ENST00000547104
resolver
enst
ENST00000548553
resolver
enst
ENST00000550097
resolver
enst
ENST00000949680
resolver
genesymbol
TMT1A
resolver
genesymbol_syn
METTL7A
resolver
hgnc
HGNC:24550
resolver
uniprot
Q9H7R3
resolver
uniprot
Q9UHZ7
resolver
uniprot
Q9Y422
resolver
uniprot_entry
TMT1A_HUMAN
resolver
uniprot_sec
Q9H7R3
resolver
uniprot_sec
Q9UHZ7
resolver
uniprot_sec
Q9Y422
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 2,3-dichloro-alpha-methylbenzylamine (DCMB). {ECO:0000269|PubMed:37137720}.
uniprot
proteins
amino_acid_sequence
MELTIFILRLAIYILTFPLYLLNFLGLWSWICKKWFPYFLVRFTVIYNEQMASKKRELFSNLQEFAGPSGKLSLLEVGCGTGANFKFYPPGCRVTCIDPNPNFEKFLIKSIAENRHLQFERFVVAAGENMHQVADGSVDVVVCTLVLCSVKNQERILREVCRVLRPGGAFYFMEHVAAECSTWNYFWQQVLDPAWHLLFDGCNLTRESWKALERASFSKLKLQHIQAPLSWELVRPHIYGYAVK
uniprot
proteins
ec_number
2.1.1.348
uniprot
proteins
ec_number
2.1.1.9
uniprot
proteins
function
FUNCTION: Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes (PubMed:37137720). Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface (PubMed:34980213). Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival (PubMed:34226523, PubMed:34790668). Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles (PubMed:19773358). {ECO:0000269|PubMed:19773358, ECO:0000269|PubMed:34980213, ECO:0000269|PubMed:37137720}.; FUNCTION: (Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation. {ECO:0000269|PubMed:26185986}.
uniprot
proteins
mass_dalton
28319
uniprot
proteins
post_translational_modification
PTM: Methylated at lysine residues most likely by EZH2. {ECO:0000269|PubMed:34980213}.
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18477614
uniprot
proteins
pubmed
19773358
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26185986
uniprot
proteins
pubmed
34226523
uniprot
proteins
pubmed
34790668
uniprot
proteins
pubmed
34980213
uniprot
proteins
pubmed
37137720
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:18477614, ECO:0000269|PubMed:19773358, ECO:0000269|PubMed:26185986}. Endoplasmic reticulum {ECO:0000269|PubMed:19773358}. Membrane {ECO:0000269|PubMed:18477614}. Microsome {ECO:0000269|PubMed:37137720}. Cytoplasm, cytosol {ECO:0000269|PubMed:37137720}. Note=Inserted in the ER membrane and migrates from the inserted site to lipid droplet. {ECO:0000269|PubMed:18477614, ECO:0000269|PubMed:19773358}.
uniprot
proteins