Gabrr1
entrez
29694
canonical
uniprot
P50572
canonical
ensembl
ENSRNOG00000007603
resolver
ensembl
ENSRNOG00065004875
resolver
ensp
ENSRNOP00000010172
resolver
ensp
ENSRNOP00065004896
resolver
enst
ENSRNOT00000010172
resolver
enst
ENSRNOT00065007084
resolver
genesymbol
Gabrr1
resolver
uniprot
F1LPA8
resolver
uniprot_entry
F1LPA8_RAT
resolver
uniprot_entry
GBRR1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by TPMPA, a rho-specific antagonist (By similarity). Inhibited by picrotoxin, when forming a homopentamer (PubMed:8524843, PubMed:8905713). In contrast with other GABAARs, rho-1 GABAAR is not inhibited by bicuculline, when forming a homopentamer (PubMed:8905713). Down-regulated by external protons when forming a homopentamer (PubMed:8905713). {ECO:0000250|UniProtKB:P24046, ECO:0000269|PubMed:8524843, ECO:0000269|PubMed:8905713}.
uniprot
proteins
amino_acid_sequence
MLAVRNMKFGIFLLWWGWVLAAESTVHWPGREVHEPSKKGSRPQRQRRGAHDDAHKQGSPILKRSSDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKISCTCGLPQPRGVMLDSSYSDGEVNDLGGYMPENGEKPDRMMVQLTLASERGSPQRKSQRGSYVSMRINTHAIDKYSRIIFPAAYILFNLIYWSIFS
uniprot
proteins
function
FUNCTION: Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:8524843, PubMed:8905713). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (By similarity). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:8524843, PubMed:8905713). Rho-1 subunits are primarily expressed in retina where rho-1-containing GABAARs may play a role in retinal neurotransmission (By similarity). Rho-1 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (By similarity). Rho-1 GABAARs may also contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (By similarity). {ECO:0000250|UniProtKB:P24046, ECO:0000250|UniProtKB:P56475, ECO:0000269|PubMed:8524843, ECO:0000269|PubMed:8905713}.
uniprot
proteins
mass_dalton
55532
uniprot
proteins
mutagenesis
MUTAGEN 316; /note="P->S: Reduced GABA-evoked current."; /evidence="ECO:0000269|PubMed:8524843"; MUTAGEN 320; /note="T->M: Reduced GABA-evoked current."; /evidence="ECO:0000269|PubMed:8524843
uniprot
proteins
protein_family
GABRR1 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
12431995
uniprot
proteins
pubmed
8524843
uniprot
proteins
pubmed
8905713
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P56475}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P24046}. Cell membrane {ECO:0000250|UniProtKB:P24046}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P24046}.
uniprot
proteins
transmembrane_region
TRANSMEM 282..302; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 315..335; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 347..367; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 459..479; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins