Phf1
entrez
21652
canonical
uniprot
Q9Z1B8
canonical
ensembl
ENSMUSG00000024193
resolver
ensp
ENSMUSP00000073402
resolver
ensp
ENSMUSP00000158483
resolver
enst
ENSMUST00000073724
resolver
enst
ENSMUST00000237412
resolver
genesymbol
Phf1
resolver
genesymbol_syn
Plc1
resolver
genesymbol_syn
Tctex-3
resolver
genesymbol_syn
Tctex3
resolver
uniprot
A0A494BBE6
resolver
uniprot
O54808
resolver
uniprot_entry
A0A494BBE6_MOUSE
resolver
uniprot_entry
PHF1_MOUSE
resolver
uniprot_sec
O54808
resolver
amino_acid_sequence
MAQLPRLSRLGAPSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGASWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDTPKGERSSQLLSALNSHKDRFISGREIKKRKCLFGLHARTPPPVELLTGDGAPTSFPSGQGPGGGVSRPLGKRWRSEPEPLRRRQKGKVEELGPPTAAHSRHGSREQRALQASVSPPPPSPNQSYEGSSGYNFRPTDARCLPSSPIRMFASFHPSASTAGTSGDSEPPDRSPLGLHIGFPTDTPKSSPHSVTASSSSVPALTPGFSRHSPPSPLCRSLSPGTGGGVRGGVSYLSRGDPVRVLARRVRPDGSVQYLVEWGGGGIF
uniprot
proteins
function
FUNCTION: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18086877). According to other reports, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2. Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. {ECO:0000269|PubMed:18086877}.
uniprot
proteins
mass_dalton
61140
uniprot
proteins
protein_family
Polycomblike family
uniprot
proteins
pubmed
10545244
uniprot
proteins
pubmed
11559747
uniprot
proteins
pubmed
18086877
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23104054
uniprot
proteins
pubmed
9799836
uniprot
proteins
sequence_length
559
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18086877}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes specifically to the promoters of numerous target genes. Localizes to double-strand breaks (DSBs) sites following DNA damage. Colocalizes with NEK6 in the centrosome (By similarity). {ECO:0000250}.
uniprot
proteins