Mcm7
entrez
17220
canonical
uniprot
Q61881
canonical
ensembl
ENSMUSG00000029730
resolver
ensp
ENSMUSP00000000505
resolver
enst
ENSMUST00000000505
resolver
genesymbol
Mcm7
resolver
genesymbol_syn
Cdc47
resolver
genesymbol_syn
MCM7
resolver
genesymbol_syn
Mcmd7
resolver
uniprot
Q3U4T8
resolver
uniprot_entry
MCM7_MOUSE
resolver
uniprot_entry
Q3U4T8_MOUSE
resolver
amino_acid_sequence
MALKDYAIEKEKVKKFLQEFYYENELGKKQFKYGTQLVHLAHREQVALYVDLDDIAEDDPELVDSICENAKRYSRLFGDVVQELLPEYKEKEVVNKDVLDVYIEHRLMMEQRSRDPGAVRNPQNQYPSELMRRFELYFRGPSSSKPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSKFVKFQEMKIQEHSDQVPVGNIPRSITVVLEGENTRIAQPGDHVSVTGIFLPVLRTGFQQMAQGLLSETYLEAHWIVKMTKSDDDVSGAGELSSEELKQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNVQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPAQFEPLDMKLMRRYIAMCHERQPTVPESLADYITAAYVEMRREARASKDATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMSKDSLLGEKGQTARTQRPADVIFATIRELVSRGRSVHFSEAEQRCISRGFTPAQFQAALDEYEELNVWQVNTSRTRITFV
uniprot
proteins
ec_number
3.6.4.12
uniprot
proteins
function
FUNCTION: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Uncomplexed form does not show ATPase or DNA helicase (PubMed:12207017). Required for S-phase checkpoint activation upon UV-induced damage (By similarity). {ECO:0000250|UniProtKB:P33993, ECO:0000269|PubMed:12207017}.
uniprot
proteins
mass_dalton
81211
uniprot
proteins
mutagenesis
MUTAGEN 387..388; /note="KS->AA: Almost abolishes MCM complex DNA helicase activity. Strongly decreases MCM complex ATPase activity. No effect on MCM complex formation. No effect on ATP and ssDNA binding."; /evidence="ECO:0000269|PubMed:12207017"; MUTAGEN 445..446; /note="DE->AA: Strongly decreases MCM complex ATPase and DNA helicase activities. No effect on MCM complex formation. No effect on ATP and ssDNA binding."; /evidence="ECO:0000269|PubMed:12207017
uniprot
proteins
post_translational_modification
PTM: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. {ECO:0000250|UniProtKB:P33993}.; PTM: Ubiquitinated by ECS(LRR1) E3 ubiquitin-protein ligase complex when forks converge following formation of DNA interstrand cross-links (PubMed:33590678). During mitosis, ubiquitinated by TRAIP when forks converge following formation of DNA interstrand cross-links (PubMed:33590678). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase (PubMed:33590678). {ECO:0000250|UniProtKB:Q91876, ECO:0000269|PubMed:33590678}.
uniprot
proteins
protein_family
MCM family
uniprot
proteins
pubmed
10567526
uniprot
proteins
pubmed
12207017
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33590678
uniprot
proteins
pubmed
8566808
uniprot
proteins
sequence_length
719
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91876}. Chromosome {ECO:0000250|UniProtKB:Q91876}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000250|UniProtKB:Q91876}.
uniprot
proteins