CADM1
entrez
23705
canonical
uniprot
Q9BY67
canonical
ensembl
ENSG00000182985
resolver
ensp
ENSP00000329797
resolver
ensp
ENSP00000395359
resolver
ensp
ENSP00000439176
resolver
ensp
ENSP00000439817
resolver
ensp
ENSP00000440322
resolver
enst
ENST00000536727
resolver
genesymbol
CADM1
resolver
genesymbol_syn
IGSF4
resolver
genesymbol_syn
IGSF4A
resolver
genesymbol_syn
NECL2
resolver
genesymbol_syn
SYNCAM
resolver
genesymbol_syn
TSLC1
resolver
hgnc
HGNC:5951
resolver
uniprot
A0A044PYB0
resolver
uniprot
A0A4Z1
resolver
uniprot
A4FVB5
resolver
uniprot
F5H0J4
resolver
uniprot
H0YGA7
resolver
uniprot
H1ZZV9
resolver
uniprot
H1ZZW1
resolver
uniprot
H1ZZW2
resolver
uniprot
Q86WB8
resolver
uniprot
Q8N2F4
resolver
uniprot
X5D2C8
resolver
uniprot
X5D7A8
resolver
uniprot
X5D8W0
resolver
uniprot
X5DQR8
resolver
uniprot
X5DQS5
resolver
uniprot_entry
A0A044PYB0_HUMAN
resolver
uniprot_entry
A0A4Z1_HUMAN
resolver
uniprot_entry
CADM1_HUMAN
resolver
uniprot_entry
X5D7A8_HUMAN
resolver
uniprot_entry
X5D8W0_HUMAN
resolver
uniprot_entry
X5DQR8_HUMAN
resolver
uniprot_entry
X5DQS5_HUMAN
resolver
uniprot_sec
A4FVB5
resolver
uniprot_sec
F5H0J4
resolver
uniprot_sec
H0YGA7
resolver
uniprot_sec
H1ZZV9
resolver
uniprot_sec
H1ZZW1
resolver
uniprot_sec
H1ZZW2
resolver
uniprot_sec
Q86WB8
resolver
uniprot_sec
Q8N2F4
resolver
uniprot_sec
X5D2C8
resolver
amino_acid_sequence
MASVVLPSGSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDSRAGEEGSIRAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI
uniprot
proteins
function
FUNCTION: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:12050160, PubMed:22438059). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). In mast cells, may mediate attachment to and promote communication with nerves (PubMed:15905536). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:22438059). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity). Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PubMed:11279526, PubMed:12234973). May contribute to the less invasive phenotypes of lepidic growth tumor cells (PubMed:12920246). {ECO:0000250|UniProtKB:Q8R5M8, ECO:0000269|PubMed:11279526, ECO:0000269|PubMed:12050160, ECO:0000269|PubMed:12234973, ECO:0000269|PubMed:12920246, ECO:0000269|PubMed:15811952, ECO:0000269|PubMed:15905536, ECO:0000269|PubMed:22438059}.; FUNCTION: [Isoform 5]: (Microbial infection) Induces cell fusion in neuron infected by a neuropathogenic strain of measles. Interacts with measles hemagglutinin to trigger hyperfusogenic F-mediated membrane fusion and presumably transsynaptic cell-to-cell transmission of the virus. {ECO:0000269|PubMed:37166307}.
uniprot
proteins
mass_dalton
48509
uniprot
proteins
mutagenesis
MUTAGEN 406; /note="Y->A: Nearly abolishes EPB41L3 binding."; /evidence="ECO:0000269|PubMed:21131357"; MUTAGEN 408; /note="T->A: Strongly reduced affinity for EPB41L3."; /evidence="ECO:0000269|PubMed:21131357
uniprot
proteins
post_translational_modification
PTM: Glycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction. {ECO:0000250}.
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
11279526
uniprot
proteins
pubmed
12050160
uniprot
proteins
pubmed
12234973
uniprot
proteins
pubmed
12920246
uniprot
proteins
pubmed
12925956
uniprot
proteins
pubmed
13679854
uniprot
proteins
pubmed
14633730
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15184878
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15781451
uniprot
proteins
pubmed
15811952
uniprot
proteins
pubmed
15893517
uniprot
proteins
pubmed
15905536
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21131357
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22438059
uniprot
proteins
pubmed
23871486
uniprot
proteins
pubmed
24503895
uniprot
proteins
pubmed
24722188
uniprot
proteins
pubmed
25268382
uniprot
proteins
pubmed
29698475
uniprot
proteins
pubmed
37166307
uniprot
proteins
sequence_length
442
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11279526, ECO:0000269|PubMed:22438059}; Single-pass type I membrane protein {ECO:0000269|PubMed:11279526}. Synapse {ECO:0000250|UniProtKB:Q8R5M8}. Note=Localized to the basolateral plasma membrane of epithelial cells in gall bladder. {ECO:0000250|UniProtKB:Q8R5M8}.
uniprot
proteins
transmembrane_region
TRANSMEM 375..395; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins