TMPRSS2
entrez
7113
canonical
uniprot
O15393
canonical
ensembl
ENSG00000184012
resolver
ensp
ENSP00000330330
resolver
ensp
ENSP00000381588
resolver
ensp
ENSP00000503877
resolver
enst
ENST00000678171
resolver
genesymbol
TMPRSS2
resolver
genesymbol_syn
PRSS10
resolver
hgnc
HGNC:11876
resolver
uniprot
A0A7I2V474
resolver
uniprot
A8K6Z8
resolver
uniprot
B2R8E5
resolver
uniprot
B7Z459
resolver
uniprot
D3DSJ2
resolver
uniprot
F8WES1
resolver
uniprot
Q6GTK7
resolver
uniprot
Q9BXX1
resolver
uniprot_entry
A0A7I2V474_HUMAN
resolver
uniprot_entry
TMPS2_HUMAN
resolver
uniprot_sec
A8K6Z8
resolver
uniprot_sec
B2R8E5
resolver
uniprot_sec
B7Z459
resolver
uniprot_sec
D3DSJ2
resolver
uniprot_sec
F8WES1
resolver
uniprot_sec
Q6GTK7
resolver
uniprot_sec
Q9BXX1
resolver
amino_acid_sequence
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
uniprot
proteins
ec_number
3.4.21.122
uniprot
proteins
function
FUNCTION: Plasma membrane-anchored serine protease that cleaves at arginine residues (PubMed:32703818, PubMed:35676539, PubMed:37990007, PubMed:38964328). Participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:25122198, PubMed:26018085). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity). {ECO:0000250|UniProtKB:Q9JIQ8, ECO:0000269|PubMed:15537383, ECO:0000269|PubMed:25122198, ECO:0000269|PubMed:26018085, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:35676539, ECO:0000269|PubMed:37990007, ECO:0000269|PubMed:38964328}.; FUNCTION: (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436, PubMed:33051876, PubMed:34159616, PubMed:35676539, PubMed:37990007). The cleavage of SARS-COV2 spike glycoprotein occurs between the S2 and S2' site (PubMed:32703818). Upon SARS-CoV-2 infection, increases syncytia formation by accelerating the fusion process (PubMed:33051876, PubMed:34159616, PubMed:35676539). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. {ECO:0000269|PubMed:21068237, ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651, ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32404436, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:34159616, ECO:0000269|PubMed:35676539, ECO:0000269|PubMed:37990007}.; FUNCTION: (Microbial infection) Receptor for human coronavirus HKU1-CoV, acts synergistically with disialoside glycans to facilitate the entry of the virus. After binding to cell-surface disialoside glycans, the viral S protein interacts with the inactive form of TMPRSS2 and inhibits its protease activity. {ECO:0000269|PubMed:38964326, ECO:0000269|PubMed:38964328, ECO:0000269|PubMed:38964329}.
uniprot
proteins
mass_dalton
53859
uniprot
proteins
mutagenesis
MUTAGEN 255; /note="R->Q: Loss of cleavage. No effect on HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:11245484, ECO:0000269|PubMed:38964326"; MUTAGEN 316; /note="R->A: No effect on catalytic activity or HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964326"; MUTAGEN 340; /note="K->D: No effect on HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964328"; MUTAGEN 341; /note="T->A,S: No effect on catalytic activity or HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964326, ECO:0000269|PubMed:38964328"; MUTAGEN 409; /note="R->A,T: No effect on catalytic activity. Reduces HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964326, ECO:0000269|PubMed:38964328"; MUTAGEN 412; /note="S->A,N: No effect on catalytic activity. Reduces HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964326, ECO:0000269|PubMed:38964328"; MUTAGEN 413; /note="R->A,K,V: No effect on catalytic activity. Reduces HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964326, ECO:0000269|PubMed:38964328"; MUTAGEN 414; /note="Y->A,S,L,R: No effect on catalytic activity. Almost abolishes S protein-binding and HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964326, ECO:0000269|PubMed:38964328, ECO:0000269|PubMed:38964329"; MUTAGEN 415; /note="V->I: No effect on HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964328"; MUTAGEN 416; /note="Y->A: No effect on catalytic activity. Almost abolishes HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964326"; MUTAGEN 417; /note="D->A,N: No effect on catalytic activity. Almost abolishes HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964326, ECO:0000269|PubMed:38964328"; MUTAGEN 419; /note="L->R,A,M: No effect on catalytic activity. Abolishes HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964326, ECO:0000269|PubMed:38964328"; MUTAGEN 430; /note="L->R: No effect on catalytic activity. Abolishes HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964326"; MUTAGEN 431; /note="Q->A: No effect on catalytic activity or HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964326"; MUTAGEN 433; /note="N->A: No effect on catalytic activity or HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964326"; MUTAGEN 441; /note="S->A: Loss of activity. No effect on HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:11245484, ECO:0000269|PubMed:38964326, ECO:0000269|PubMed:38964328, ECO:0000269|PubMed:38964329"; MUTAGEN 461; /note="W->A: No effect on catalytic activity. Abolishes HKU1-CoVS protein-binding and viral entry."; /evidence="ECO:0000269|PubMed:38964326, ECO:0000269|PubMed:38964328"; MUTAGEN 463; /note="S->A,T,Y,F: No effect on catalytic activity. Reduces HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964326, ECO:0000269|PubMed:38964328"; MUTAGEN 467; /note="K->A: No effect on catalytic activity. Reduces HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964326"; MUTAGEN 468; /note="A->P: No effect on HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964328"; MUTAGEN 469; /note="Y->A,N,L: No effect on catalytic activity. Reduces HKU1-CoV viral entry."; /evidence="ECO:0000269|PubMed:38964326, ECO:0000269|PubMed:38964328, ECO:0000269|PubMed:38964329"; MUTAGEN 470; /note="R->A,K: No effect on catalytic activity. Abolishes HKU1-CoVS protein-binding and viral entry."; /evidence="ECO:0000269|PubMed:38964326, ECO:0000269|PubMed:38964328, ECO:0000269|PubMed:38964329
uniprot
proteins
post_translational_modification
PTM: Proteolytically processed; by an autocatalytic mechanism. Autocleavage induces active conformation. {ECO:0000269|PubMed:11245484, ECO:0000269|PubMed:38964326, ECO:0000269|PubMed:38964328}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
11169526
uniprot
proteins
pubmed
11245484
uniprot
proteins
pubmed
11414763
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15537383
uniprot
proteins
pubmed
17918732
uniprot
proteins
pubmed
20382709
uniprot
proteins
pubmed
21068237
uniprot
proteins
pubmed
21325420
uniprot
proteins
pubmed
23536651
uniprot
proteins
pubmed
23966399
uniprot
proteins
pubmed
24027332
uniprot
proteins
pubmed
24227843
uniprot
proteins
pubmed
25122198
uniprot
proteins
pubmed
26018085
uniprot
proteins
pubmed
32142651
uniprot
proteins
pubmed
32327758
uniprot
proteins
pubmed
32404436
uniprot
proteins
pubmed
32703818
uniprot
proteins
pubmed
32867305
uniprot
proteins
pubmed
33051876
uniprot
proteins
pubmed
33522642
uniprot
proteins
pubmed
34159616
uniprot
proteins
pubmed
35676539
uniprot
proteins
pubmed
37990007
uniprot
proteins
pubmed
38964326
uniprot
proteins
pubmed
38964328
uniprot
proteins
pubmed
38964329
uniprot
proteins
pubmed
9325052
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237, ECO:0000269|PubMed:38964328}; Single-pass type II membrane protein {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}.; SUBCELLULAR LOCATION: [Transmembrane protease serine 2 catalytic chain]: Secreted {ECO:0000269|PubMed:20382709}. Note=Activated by cleavage and secreted. {ECO:0000269|PubMed:11245484, ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:38964328}.
uniprot
proteins
transmembrane_region
TRANSMEM 85..105; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins