H1.8
entrez
171506
canonical
uniprot
Q8VIK3
canonical
ensembl
ENSMUSG00000042279
resolver
ensp
ENSMUSP00000036951
resolver
ensp
ENSMUSP00000123797
resolver
genesymbol
H1.8
resolver
genesymbol_syn
H1f8
resolver
genesymbol_syn
H1foo
resolver
genesymbol_syn
H1oo
resolver
uniprot_entry
H18_MOUSE
resolver
amino_acid_sequence
MAPGSVSSVSSSSFPSRDTSPSGSCGLPGADKPGPSCRRIQAGQRNPTMLHMVLEALKAREARQGTSVVAIKVYIQHKYPTVDTTRFKYLLKQALETGVRRGLLTRPAHSKAKGATGSFKLVPKPKTKKACAPKAGRGAAGAKETGSKKSGLLKKDQVGKATMEKGQKRRAYPCKAATLEMAPKKAKAKPKEVRKAPLKQDKAAGAPLTANGGQKVKRSGSRQEANAHGKTKGEKSKPLASKVQNSVASLAKRKMADMAHTVTVVQGAETVQETKVPTPSQDIGHKVQPIPRVRKAKTPENTQA
uniprot
proteins
function
FUNCTION: May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling. {ECO:0000269|PubMed:11171391, ECO:0000269|PubMed:14729479, ECO:0000269|PubMed:15371275, ECO:0000269|PubMed:17519519}.
uniprot
proteins
mass_dalton
32223
uniprot
proteins
protein_family
Histone H1/H5 family
uniprot
proteins
pubmed
11171391
uniprot
proteins
pubmed
14729479
uniprot
proteins
pubmed
15371275
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17519519
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus. Chromosome. Note=In the germinal vesicle oocyte, localizes to the condensed chromosomes. In the 1-cell embryo found in condensed maternal metaphase chromatin but not in the sperm head. Following second polar body extrusion, detected in the swollen sperm head as well as in the second polar body. Reduced expression in the nucleus in 2-cell embryo is seen as compared to 1-cell embryo.
uniprot
proteins