Mid2
entrez
23947
canonical
uniprot
Q9QUS6
canonical
ensembl
ENSMUSG00000000266
resolver
ensp
ENSMUSP00000108614
resolver
ensp
ENSMUSP00000108617
resolver
ensp
ENSMUSP00000300755
resolver
enst
ENSMUST00000112990
resolver
enst
ENSMUST00000112993
resolver
genesymbol
Mid2
resolver
genesymbol_syn
Fxy2
resolver
genesymbol_syn
Trim1
resolver
uniprot
B1AVF4
resolver
uniprot_entry
B1AVF4_MOUSE
resolver
uniprot_entry
TRIM1_MOUSE
resolver
amino_acid_sequence
MGESPASAVLNASAGLFSLKMETLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSESRRERTYRPSSAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPFTSHRLVEPVSDTHLRGITCLDHENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLKQTLEMNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVAMATASSQVLIPDINFNDAFENFALDFSREKKLLEGLDYLTAPNPPSIREELCTASHDTITVHWISDDEFSISSYELQYTIFTGQANFISLYNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAGSRNSEPTRLKTNSQPFKLDPKMTHKKLKISNDGLQMEKDESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMGSSTWYAIGIAYKSAPKNEWIGKNASSWVFSRCNSNFVVRHNNKEMLVDVPPQLKRLGVLLDYDNNMLSFYDPANSLHLHTFDVTFILPVCPTFTIWNKSLMILSGLPAPDFIDYPERQECNCRPQESPYVSGMKACH
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays a role in microtubule stabilization (By similarity). Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 kinase activation by RAB29 (By similarity). {ECO:0000250|UniProtKB:Q9UJV3}.
uniprot
proteins
mass_dalton
79774
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues (By similarity). {ECO:0000250|UniProtKB:Q9UJV3}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
10400986
uniprot
proteins
pubmed
10644436
uniprot
proteins
sequence_length
705
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UJV3}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9UJV3}. Note=Microtubule-associated. {ECO:0000250|UniProtKB:Q9UJV3}.
uniprot
proteins