LTB
entrez
4050
canonical
uniprot
Q06643
canonical
ensembl
ENSG00000204487
resolver
ensembl
ENSG00000206437
resolver
ensembl
ENSG00000223448
resolver
ensembl
ENSG00000227507
resolver
ensembl
ENSG00000231314
resolver
ensembl
ENSG00000236237
resolver
ensembl
ENSG00000236925
resolver
ensembl
ENSG00000238114
resolver
ensp
ENSP00000410481
resolver
ensp
ENSP00000416113
resolver
genesymbol
LTB
resolver
genesymbol_syn
TNFC
resolver
genesymbol_syn
TNFSF3
resolver
hgnc
HGNC:6711
resolver
uniprot
P78370
resolver
uniprot
Q52LU8
resolver
uniprot
Q99761
resolver
uniprot_entry
TNFC_HUMAN
resolver
uniprot_sec
P78370
resolver
uniprot_sec
Q52LU8
resolver
uniprot_sec
Q99761
resolver
amino_acid_sequence
MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLEGAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGAVMVG
uniprot
proteins
function
FUNCTION: Cytokine that binds to LTBR/TNFRSF3 (PubMed:24248355). May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. {ECO:0000269|PubMed:24248355}.
uniprot
proteins
mass_dalton
25390
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="K->E: In subunit 1; reduces binding of LTA(1)-LTB(2) to LTBR and abolishes LTBR-mediated NF-kappa-B signaling activation; when associated with R-109 and E-142, and 'A-142' in LTA. In subunit 2; reduces binding of LTA(1)-LTB(2) to LTBR and abolishes LTBR-mediated NF-kappa-B signaling activation; when associated with R-109 and E-142, and with 'A-170' in LTB (subunit 1). In subunit 1; abolishes binding of LTA(1)-LTB(2) to LTBR and abolishes LTBR-mediated NF-kappa-B signaling activation; when associated with R-109; E-142 and A-170, and with 'E-108'; 'R-109' and 'E-142' in LTB (subunit 2), and with 'A-142' in LTA."; /evidence="ECO:0000269|PubMed:24248355"; MUTAGEN 109; /note="E->R: In subunit 1; reduces binding of LTA(1)-LTB(2) to LTBR and abolishes LTBR-mediated NF-kappa-B signaling activation; when associated with E-108 and E-142, and 'A-142' in LTA. In subunit 2; reduces binding of LTA(1)-LTB(2) to LTBR and abolishes LTBR-mediated NF-kappa-B signaling activation; when associated with E-108 and E-142, and with 'A-170' in LTB (subunit 1). In subunit 1; abolishes binding of LTA(1)-LTB(2) to LTBR and abolishes LTBR-mediated NF-kappa-B signaling activation; when associated with E-108; E-142 and A-170, and with 'E-108'; 'R-109' and 'E-142' in LTB (subunit 2), and with 'A-142' in LTA."; /evidence="ECO:0000269|PubMed:24248355"; MUTAGEN 142; /note="R->E: In subunit 1; reduces binding of LTA(1)-LTB(2) to LTBR and abolishes LTBR-mediated NF-kappa-B signaling activation; when associated with E-108 and R-109, and 'A-142' in LTA. In subunit 2; reduces binding of LTA(1)-LTB(2) to LTBR and abolishes LTBR-mediated NF-kappa-B signaling activation; when associated with E-108 and R-109, and with 'A-170' in LTB (subunit 1). In subunit 1; abolishes binding of LTA(1)-LTB(2) to LTBR and abolishes LTBR-mediated NF-kappa-B signaling activation; when associated with E-108; R-109 and A-170, and with 'E-108'; 'R-109' and 'E-142' in LTB (subunit 2), and with 'A-142' in LTA."; /evidence="ECO:0000269|PubMed:24248355"; MUTAGEN 170; /note="Y->A: In subunit 2; no significant effect on binding of LTA(1)-LTB(2) to LTBR and LTBR-mediated NF-kappa-B signaling activation. In subunit 1; reduces binding of LTA(1)-LTB(2) to LTBR and abolishes LTBR-mediated NF-kappa-B signaling activation; when associated with 'E-108', 'R-109' and 'E-142' in LTB (subunit 2). In subunit 1, abolishes binding of LTA(1)-LTB(2) to LTBR and abolishes LTBR-mediated NF-kappa-B signaling activation; when associated with E-108; R-109 and E-142, and with 'E-108'; 'R-109' and 'E-142' in LTB (subunit 2), and with 'A-142' in LTA."; /evidence="ECO:0000269|PubMed:24248355
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
10202016
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24248355
uniprot
proteins
pubmed
7916655
uniprot
proteins
pubmed
9299492
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..48; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins