SIGLEC15
entrez
284266
canonical
uniprot
Q6ZMC9
canonical
ensembl
ENSG00000197046
resolver
ensp
ENSP00000374125
resolver
genesymbol
SIGLEC15
resolver
genesymbol_syn
CD33L3
resolver
hgnc
HGNC:27596
resolver
uniprot
A8K2Y5
resolver
uniprot
B4DVQ9
resolver
uniprot_entry
SIG15_HUMAN
resolver
uniprot_sec
A8K2Y5
resolver
uniprot_sec
B4DVQ9
resolver
amino_acid_sequence
MEKSIWLLACLAWVLPTGSFVRTKIDTTENLLNTEVHSSPAQRWSMQVPPEVSAEAGDAAVLPCTFTHPHRHYDGPLTAIWRAGEPYAGPQVFRCAAARGSELCQTALSLHGRFRLLGNPRRNDLSLRVERLALADDRRYFCRVEFAGDVHDRYESRHGVRLHVTAAPRIVNISVLPSPAHAFRALCTAEGEPPPALAWSGPALGNSLAAVRSPREGHGHLVTAELPALTHDGRYTCTAANSLGRSEASVYLFRFHGASGASTVALLLGALGFKALLLLGVLAARAARRRPEHLDTPDTPPRSQAQESNYENLSQMNPRSPPATMCSP
uniprot
proteins
function
FUNCTION: Binds sialylated glycoproteins. {ECO:0000269|PubMed:17483134}.
uniprot
proteins
mass_dalton
35653
uniprot
proteins
mutagenesis
MUTAGEN 143; /note="R->A: Abrogates glycan-binding."; /evidence="ECO:0000269|PubMed:17483134"; MUTAGEN 274; /note="K->A: Abrogates interaction with HCST and TYROBP."; /evidence="ECO:0000269|PubMed:17483134
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
SIGLEC (sialic acid binding Ig-like lectin) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
17483134
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 264..284; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins