Q61234
uniprot
Q61234
canonical
amino_acid_sequence
MASGRRAPRTGLLELRCGAGSGAGGERWQRVLLSLAEDALTVSPADGEPGPEPEPAQLNGAAEPGAAPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQALKKTGKEVVLEVKYMKEVSPYFKNSAGGTSVGWDSPPASPLQRQPSSPGPQPRNLSEAKHVSLKMAYVSRRCTPTDPEPRYLEICAADGQDAVFLRAKDEASARSWAGAIQAQIGTFIPWVKDELQALLTATGTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEKELLFYCSLPQSREALSRPTRTAPLIATSSAHRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGIQEVSTACTWNGRPCSLSVHIDKGFTLWAAEPGAARAMLLRQPFEKLQMSSDDGTSLLFLDFGGAEGEIQLDLHSCPKTMVFIIHSFLSAKVTRLGLLA
uniprot
proteins
function
FUNCTION: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate.
uniprot
proteins
mass_dalton
53665
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CaM-kinase II (PubMed:10525145). Phosphorylation may inhibit the interaction with DMD. Phosphorylated by SRC; phosphorylation mediates laminin-induced activation of RAC1 signaling (PubMed:18044967). {ECO:0000269|PubMed:10525145, ECO:0000269|PubMed:18044967}.
uniprot
proteins
protein_family
Syntrophin family
uniprot
proteins
pubmed
10220348
uniprot
proteins
pubmed
10525145
uniprot
proteins
pubmed
10893187
uniprot
proteins
pubmed
10913299
uniprot
proteins
pubmed
11551227
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18044967
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22371502
uniprot
proteins
pubmed
7547961
uniprot
proteins
pubmed
7691103
uniprot
proteins
pubmed
8625413
uniprot
proteins
pubmed
9063877
uniprot
proteins
pubmed
9214383
uniprot
proteins
pubmed
9412493
uniprot
proteins
sequence_length
503
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000269|PubMed:9214383}; Peripheral membrane protein {ECO:0000269|PubMed:9214383}; Cytoplasmic side {ECO:0000269|PubMed:9214383}. Cell junction {ECO:0000269|PubMed:9214383}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9214383}. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.
uniprot
proteins