Hax1
entrez
23897
canonical
uniprot
O35387
canonical
ensembl
ENSMUSG00000027944
resolver
ensp
ENSMUSP00000078661
resolver
ensp
ENSMUSP00000142445
resolver
ensp
ENSMUSP00000142627
resolver
ensp
ENSMUSP00000143155
resolver
enst
ENSMUST00000079724
resolver
enst
ENSMUST00000197767
resolver
enst
ENSMUST00000197786
resolver
enst
ENSMUST00000198782
resolver
genesymbol
Hax1
resolver
genesymbol_syn
Hs1bp1
resolver
uniprot
A0A0G2JDP0
resolver
uniprot
A0A0G2JE46
resolver
uniprot
A0A0G2JFF9
resolver
uniprot
B9EJR4
resolver
uniprot
Q3UXX9
resolver
uniprot
Q542F8
resolver
uniprot
Q8R5I5
resolver
uniprot_entry
A0A0G2JDP0_MOUSE
resolver
uniprot_entry
A0A0G2JE46_MOUSE
resolver
uniprot_entry
A0A0G2JFF9_MOUSE
resolver
uniprot_entry
B9EJR4_MOUSE
resolver
uniprot_entry
HAX1_MOUSE
resolver
uniprot_entry
Q3UXX9_MOUSE
resolver
uniprot_entry
Q8R5I5_MOUSE
resolver
uniprot_sec
Q542F8
resolver
amino_acid_sequence
MSVFDLFRGFFGFPGPRSHRDPFFGGMTRDDDDDDDDDDEAEEDRGAWGRESYAFDGSQPPEEFGFSFSPRGGMRFHGNFGFDDLVRDFNSIFSEMGAWTLPSHSPELPGPESETPGERLREGQTLRDSMLKYPDSHQPRIFEGVLESHAKPESPKPAPDWGSQGPFHRLDDTWPVSPHSRAKEDKDLDSQVSQEGLGPLLQPQPKSYFKSISVTKITKPDGTVEERRTVVDSEGRRETTVTHQEAHDSSRSDPDSQRSSALDDPFSILDLLLGRWFRSR
uniprot
proteins
function
FUNCTION: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. {ECO:0000250|UniProtKB:O00165}.
uniprot
proteins
mass_dalton
31654
uniprot
proteins
protein_family
HAX1 family
uniprot
proteins
pubmed
10760273
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16814492
uniprot
proteins
pubmed
18288109
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26915802
uniprot
proteins
pubmed
26997484
uniprot
proteins
sequence_length
280
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:16814492, ECO:0000269|PubMed:26915802}. Endoplasmic reticulum {ECO:0000269|PubMed:10760273}. Nucleus membrane {ECO:0000305|PubMed:16814492}. Cytoplasmic vesicle {ECO:0000269|PubMed:10760273, ECO:0000269|PubMed:16814492}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:O00165}. Cell membrane {ECO:0000250|UniProtKB:O00165}; Peripheral membrane protein {ECO:0000250|UniProtKB:O00165}; Cytoplasmic side {ECO:0000250|UniProtKB:O00165}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q7TSE9}. Cytoplasm, P-body {ECO:0000250|UniProtKB:O00165}. Cytoplasm {ECO:0000250|UniProtKB:O00165}. Nucleus {ECO:0000250|UniProtKB:O00165}. Note=Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited (in vitro). {ECO:0000250|UniProtKB:O00165}.
uniprot
proteins