Igfbp1
entrez
16006
canonical
uniprot
P47876
canonical
ensembl
ENSMUSG00000020429
resolver
ensp
ENSMUSP00000020704
resolver
enst
ENSMUST00000020704
resolver
genesymbol
Igfbp1
resolver
genesymbol_syn
Igfbp-1
resolver
uniprot
Q5SVY8
resolver
uniprot
Q61732
resolver
uniprot_entry
IBP1_MOUSE
resolver
uniprot_sec
Q5SVY8
resolver
uniprot_sec
Q61732
resolver
amino_acid_sequence
MPEFLTVVSWPFLILLSFQIGVAAGAPQPWHCAPCTAERLGLCPPVPASCPEISRPAGCGCCPTCALPMGAACGVATARCAQGLSCRALPGEPRPLHALTRGQGACVPEPAAPATSTLFSSQHEEAKAAVVSADELSESPEMTEEQLLDSFHLMAPSREDQPILWNAISTYSSMRAREIADLKKWKEPCQRELYKVLERLAAAQQKAGDEIYKFYLPNCNKNGFYHSKQCETSLDGEAGLCWCVYPWSGKKIPGSLETRGDPNCHQYFNVHN
uniprot
proteins
function
FUNCTION: Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner. Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif. Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (By similarity). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (By similarity). {ECO:0000250|UniProtKB:P08833, ECO:0000250|UniProtKB:P21743}.
uniprot
proteins
mass_dalton
29570
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7509771
uniprot
proteins
pubmed
7529732
uniprot
proteins
sequence_length
272
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P08833}.
uniprot
proteins