Hmgb3
entrez
15354
canonical
uniprot
O54879
canonical
ensembl
ENSMUSG00000015217
resolver
ensp
ENSMUSP00000015361
resolver
ensp
ENSMUSP00000086260
resolver
ensp
ENSMUSP00000110229
resolver
ensp
ENSMUSP00000110232
resolver
ensp
ENSMUSP00000284625
resolver
ensp
ENSMUSP00000284626
resolver
ensp
ENSMUSP00000284627
resolver
ensp
ENSMUSP00000284633
resolver
enst
ENSMUST00000015361
resolver
enst
ENSMUST00000072699
resolver
enst
ENSMUST00000088874
resolver
enst
ENSMUST00000114582
resolver
genesymbol
Hmgb3
resolver
genesymbol_syn
Hmg2a
resolver
genesymbol_syn
Hmg4
resolver
uniprot
Q544R9
resolver
uniprot_entry
HMGB3_MOUSE
resolver
uniprot_entry
Q544R9_MOUSE
resolver
amino_acid_sequence
MAKGDPKKPKGKMSAYAFFVQTCREEHKKKNPEVPVNFAEFSKKCSERWKTMSSKEKSKFDEMAKADKVRYDREMKDYGPAKGGKKKKDPNAPKRPPSGFFLFCSEFRPKIKSTNPGISIGDVAKKLGEMWNNLSDNEKQPYVTKAAKLKEKYEKDVADYKSKGKFDGAKGPAKVARKKVEEEEEEEEEEEEEEEEEEDE
uniprot
proteins
function
FUNCTION: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (PubMed:19890330). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (PubMed:12714519, PubMed:15358624, PubMed:16945912). {ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P40618, ECO:0000269|PubMed:12714519, ECO:0000269|PubMed:15358624, ECO:0000269|PubMed:16945912, ECO:0000269|PubMed:19890330}.
uniprot
proteins
mass_dalton
23010
uniprot
proteins
post_translational_modification
PTM: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-104 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB3 (HMGB3C23hC45hC104h), 2- disulfide HMGB3 (HMGB3C23-C45C104h) and 3- sulfonyl HMGB3 (HMGB3C23soC45soC104so). {ECO:0000250|UniProtKB:P09429}.
uniprot
proteins
protein_family
HMGB family
uniprot
proteins
pubmed
12714519
uniprot
proteins
pubmed
15358624
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16945912
uniprot
proteins
pubmed
19890330
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9598312
uniprot
proteins
sequence_length
200
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40618, ECO:0000255|PROSITE-ProRule:PRU00267}. Chromosome {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:19890330}.
uniprot
proteins