GET1
entrez
7485
canonical
uniprot
O00258
canonical
ensembl
ENSG00000182093
resolver
ensp
ENSP00000370084
resolver
ensp
ENSP00000381737
resolver
ensp
ENSP00000496813
resolver
genesymbol
GET1
resolver
genesymbol_syn
CHD5
resolver
genesymbol_syn
WRB
resolver
hgnc
HGNC:12790
resolver
uniprot
A8KAP8
resolver
uniprot
A8MQ44
resolver
uniprot
D3DSH9
resolver
uniprot
O60740
resolver
uniprot_entry
GET1_HUMAN
resolver
uniprot_sec
A8KAP8
resolver
uniprot_sec
A8MQ44
resolver
uniprot_sec
D3DSH9
resolver
uniprot_sec
O60740
resolver
amino_acid_sequence
MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYVLQAALMISLIWKYYSVPVAVVPSKWITPLDRLVAFPTRVAGGVGITCWILVCNKVVAIVLHPFS
uniprot
proteins
function
FUNCTION: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER) (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539). Required to ensure correct topology and ER insertion of CAMLG (PubMed:31417168, PubMed:32187542). {ECO:0000269|PubMed:21444755, ECO:0000269|PubMed:23041287, ECO:0000269|PubMed:24392163, ECO:0000269|PubMed:27226539, ECO:0000269|PubMed:31417168, ECO:0000269|PubMed:32187542}.
uniprot
proteins
mass_dalton
19780
uniprot
proteins
protein_family
WRB/GET1 family
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21444755
uniprot
proteins
pubmed
23041287
uniprot
proteins
pubmed
24392163
uniprot
proteins
pubmed
27226539
uniprot
proteins
pubmed
31417168
uniprot
proteins
pubmed
32187542
uniprot
proteins
pubmed
32910895
uniprot
proteins
pubmed
9544840
uniprot
proteins
sequence_length
174
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21444755}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 149..169; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins