Rnf182
entrez
328234
canonical
uniprot
Q8C432
canonical
ensembl
ENSMUSG00000044164
resolver
ensp
ENSMUSP00000062005
resolver
ensp
ENSMUSP00000300578
resolver
enst
ENSMUST00000059986
resolver
genesymbol
Rnf182
resolver
uniprot_entry
RN182_MOUSE
resolver
amino_acid_sequence
MASQPLEEPAESQASDELECKICYNRYNLKQRKPKVLECCHRVCAKCLYKIIDFGDSPQGVIVCPFCRFETCLPDDEVSSLPDDNNILVNLTCGGKGKKCLPENPTELLLTPKRLASLVSPSHTSSNCLVITIMEVQRESSPSLSSTPVVEFYRPASFDSVTTVSHNWTVWNCTSLLFQTSIRVLVWLLGLLYFSSLPLGIYLLVSKKVTLGVVFVSLVPSSLVILMVYGFCQCVCHEFLDCMALPS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Also plays a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. {ECO:0000250|UniProtKB:Q8N6D2}.
uniprot
proteins
mass_dalton
27444
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8N6D2}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18298843
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8N6D2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N6D2}. Cytoplasm {ECO:0000250|UniProtKB:Q8N6D2}.
uniprot
proteins
transmembrane_region
TRANSMEM 184..204; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins