TMEM87B
entrez
84910
canonical
uniprot
Q96K49
canonical
ensembl
ENSG00000153214
resolver
ensp
ENSP00000283206
resolver
ensp
ENSP00000498298
resolver
enst
ENST00000650799
resolver
genesymbol
TMEM87B
resolver
hgnc
HGNC:25913
resolver
uniprot
A0A494BZZ8
resolver
uniprot
A8K2M9
resolver
uniprot
Q1RLN2
resolver
uniprot
Q53R54
resolver
uniprot_entry
A0A494BZZ8_HUMAN
resolver
uniprot_entry
TM87B_HUMAN
resolver
uniprot_sec
A8K2M9
resolver
uniprot_sec
Q1RLN2
resolver
uniprot_sec
Q53R54
resolver
amino_acid_sequence
MVAACRSVAGLLPRRRRCFPARAPLLRVALCLLCWTPAAVRAVPELGLWLETVNDKSGPLIFRKTMFNSTDIKLSVKSFHCSGPVKFTIVWHLKYHTCHNEHSNLEELFQKHKLSVDEDFCHYLKNDNCWTTKNENLDCNSDSQVFPSLNNKELINIRNVSNQERSMDVVARTQKDGFHIFIVSIKTENTDASWNLNVSLSMIGPHGYISASDWPLMIFYMVMCIVYILYGILWLTWSACYWKDILRIQFWIAAVIFLGMLEKAVFYSEYQNISNTGLSTQGLLIFAELISAIKRTLARLLVIIVSLGYGIVKPRLGTVMHRVIGLGLLYLIFAAVEGVMRVIGGSNHLAVVLDDIILAVIDSIFVWFIFISLAQTMKTLRLRKNTVKFSLYRHFKNTLIFAVLASIVFMGWTTKTFRIAKCQSDWMERWVDDAFWSFLFSLILIVIMFLWRPSANNQRYAFMPLIDDSDDEIEEFMVTSENLTEGIKLRASKSVSNGTAKPATSENFDEDLKWVEENIPSSFTDVALPVLVDSDEEIMTRSEMAEKMFSSEKIM
uniprot
proteins
disease_involvement
DISEASE: Note=TMEM87B mutations may be involved in restrictive cardiomyopathy (RCM), a rare non-ischemic myocardial disease. RCM is characterized by restrictive ventricular-filling physiology in the presence of normal or reduced diastolic and/or systolic volumes (of 1 or both ventricles), biatrial enlargement, and normal ventricular wall thickness. {ECO:0000269|PubMed:27148590}.
uniprot
proteins
function
FUNCTION: May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). {ECO:0000269|PubMed:26157166}.
uniprot
proteins
mass_dalton
63536
uniprot
proteins
protein_family
LU7TM family
uniprot
proteins
protein_family
TMEM87 subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26157166
uniprot
proteins
pubmed
27148590
uniprot
proteins
sequence_length
555
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305|PubMed:26157166}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 215..235; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 248..268; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 300..320; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 323..343; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 351..371; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 397..417; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 430..450; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins