Cnp
entrez
12799
canonical
uniprot
P16330
canonical
ensembl
ENSMUSG00000006782
resolver
ensp
ENSMUSP00000099409
resolver
genesymbol
Cnp
resolver
genesymbol_syn
Cnp1
resolver
uniprot
Q3TYL9
resolver
uniprot
Q3TYV5
resolver
uniprot
Q61424
resolver
uniprot
Q8C7C9
resolver
uniprot
Q91V42
resolver
uniprot
Q923F3
resolver
uniprot_entry
CN37_MOUSE
resolver
uniprot_entry
Q3TYL9_MOUSE
resolver
uniprot_entry
Q3TYV5_MOUSE
resolver
uniprot_sec
Q61424
resolver
uniprot_sec
Q8C7C9
resolver
uniprot_sec
Q91V42
resolver
uniprot_sec
Q923F3
resolver
amino_acid_sequence
MNTSFTRKSHTFLPKLFFRKMSSSGAKEKPELQFPFLQDEDTVATLHECKTLFILRGLPGSGKSTLARLILEKYHDGTKMVSADAYKIIPGSRADFSEAYKRLDEDLAGYCRRDIRVLVLDDTNHERERLDQLFEMADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLKPGLEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFISGDEPKEKLELVSYFGKRPPGVLHCTTKFCDYGKAAGAEEYAQQEVVKRSYGKAFKLSISALFVTPKTAGAQVVLTDQELQLWPSDLDKPSASEGLPPGSRAHVTLGCAADVQPVQTGLDLLDILQQVKGGSQGEAVGELPRGKLYSLGKGRWMLSLTKKMEVKAIFTGYYGKGKPVPIHGSRKGGAMQICTII
uniprot
proteins
ec_number
3.1.4.37
uniprot
proteins
function
FUNCTION: Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides (PubMed:22393399). In the mitochondria, regulates the functioning of the mitochondrial permeability transition pore (mPTP), and thus is involved in the mechanisms of cell death, both apoptosis and necrosis. Acts as an antiviral factor by suppressing the assembly of SARS-CoV-2 virions. {ECO:0000250|UniProtKB:P06623, ECO:0000250|UniProtKB:P09543, ECO:0000269|PubMed:22393399}.
uniprot
proteins
mass_dalton
47123
uniprot
proteins
post_translational_modification
PTM: Acetylated. Acetylation suppresses enzymatic activity through restricting substrate accessibility. Deacetylated by SIRT3. {ECO:0000250|UniProtKB:P09543}.
uniprot
proteins
protein_family
2H phosphoesterase superfamily
uniprot
proteins
protein_family
CNPase family
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18076147
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2167669
uniprot
proteins
pubmed
22393399
uniprot
proteins
pubmed
2558653
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:18076147}; Lipid-anchor {ECO:0000269|PubMed:18076147}. Melanosome {ECO:0000250|UniProtKB:P09543}. Mitochondrion {ECO:0000250|UniProtKB:P09543}. Note=Firmly bound to membrane structures of brain white matter. {ECO:0000269|PubMed:18076147}.
uniprot
proteins