CCL8
entrez
6355
canonical
uniprot
P80075
canonical
ensembl
ENSG00000108700
resolver
ensp
ENSP00000378118
resolver
enst
ENST00000394620
resolver
genesymbol
CCL8
resolver
genesymbol_syn
MCP2
resolver
genesymbol_syn
SCYA10
resolver
genesymbol_syn
SCYA8
resolver
hgnc
HGNC:10635
resolver
uniprot
A0AV77
resolver
uniprot
P78388
resolver
uniprot_entry
CCL8_HUMAN
resolver
uniprot_sec
A0AV77
resolver
uniprot_sec
P78388
resolver
amino_acid_sequence
MKVSAALLCLLLMAATFSPQGLAQPDSVSIPITCCFNVINRKIPIQRLESYTRITNIQCPKEAVIFKTKRGKEVCADPKERWVRDSMKHLDQIFQNLKP
uniprot
proteins
function
FUNCTION: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. {ECO:0000269|PubMed:9558113}.
uniprot
proteins
mass_dalton
11246
uniprot
proteins
post_translational_modification
PTM: N-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood monocytes. {ECO:0000269|PubMed:9558113}.
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
11087354
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1613466
uniprot
proteins
pubmed
2518726
uniprot
proteins
pubmed
8898111
uniprot
proteins
pubmed
9070881
uniprot
proteins
pubmed
9119400
uniprot
proteins
pubmed
9558113
uniprot
proteins
sequence_length
99
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins