Dach1
entrez
13134
canonical
uniprot
Q9QYB2
canonical
ensembl
ENSMUSG00000055639
resolver
ensp
ENSMUSP00000064970
resolver
ensp
ENSMUSP00000071464
resolver
genesymbol
Dach1
resolver
genesymbol_syn
Dach
resolver
uniprot
B2RUG1
resolver
uniprot
O88716
resolver
uniprot
Q3UTV2
resolver
uniprot
Q80WU5
resolver
uniprot
Q8BPQ0
resolver
uniprot
Q8C8D7
resolver
uniprot
Q9QY47
resolver
uniprot
Q9R218
resolver
uniprot
Q9Z0Y5
resolver
uniprot_entry
DACH1_MOUSE
resolver
uniprot_entry
Q3UTV2_MOUSE
resolver
uniprot_entry
Q80WU5_MOUSE
resolver
uniprot_sec
B2RUG1
resolver
uniprot_sec
O88716
resolver
uniprot_sec
Q8BPQ0
resolver
uniprot_sec
Q8C8D7
resolver
uniprot_sec
Q9QY47
resolver
uniprot_sec
Q9R218
resolver
uniprot_sec
Q9Z0Y5
resolver
amino_acid_sequence
MAVPAALIPPTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASSASSSAAATVTSPGGGGGGSGGGGGSGGNGGGGGSNCNPSLAAGSSGGGVSAGGGGASSTPITASTGSSSSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNASSRPGRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPPTGLTAAAAAAAAATNAAIAEAMKVKKIKLEAMSNYHASNNQHGADSENGDMNSSVGSSGGSWDKETLHSPPSQGSQAPVAHARMPAAFSLPVSHPLNHLQHSHLPPNGLELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAAQVQSPPSRVETSVIKERVPDSPSPAPSLEEGRRPGSHPSSHRSSSVSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHESKRIHIEKDETPLSTPTARDSIDKLSLTGHGQPLPPGFPSPFLFPDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFETKRREQAEQTLKQAASADSLRVLNDSLTPEIEADRSGGRADAERTIQDGRLYLKTTVMY
uniprot
proteins
function
FUNCTION: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation also seems to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1 (By similarity). Binds to chromatin DNA via its DACHbox-N domain. {ECO:0000250, ECO:0000269|PubMed:12130660, ECO:0000269|PubMed:12215533, ECO:0000269|PubMed:14628042}.
uniprot
proteins
mass_dalton
77972
uniprot
proteins
protein_family
DACH/dachshund family
uniprot
proteins
pubmed
10502109
uniprot
proteins
pubmed
10502110
uniprot
proteins
pubmed
11543628
uniprot
proteins
pubmed
12130660
uniprot
proteins
pubmed
12215533
uniprot
proteins
pubmed
14628042
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9651501
uniprot
proteins
pubmed
9915577
uniprot
proteins
sequence_length
751
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins