Ranbp9
entrez
56705
canonical
uniprot
P69566
canonical
ensembl
ENSMUSG00000038546
resolver
ensp
ENSMUSP00000130636
resolver
ensp
ENSMUSP00000152620
resolver
enst
ENSMUST00000144326
resolver
genesymbol
Ranbp9
resolver
genesymbol_syn
Ranbpm
resolver
uniprot
E9Q5D6
resolver
uniprot
P84500
resolver
uniprot
Q3V136
resolver
uniprot_entry
E9Q5D6_MOUSE
resolver
uniprot_entry
RANB9_MOUSE
resolver
uniprot_sec
P84500
resolver
uniprot_sec
Q3V136
resolver
amino_acid_sequence
MSGQPPPPPPQQQPPPPPPPASAAAPATAPPGLAVGPGPAAGVPVPGLAAGSSAAAPFPHGDSALNEQEKELQRRLKRLYPAVDEQETPLPRSWSPKDKFSYIGLSQNNLRVHYKGHGKTPKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINNTCFYTKNGHSLGIAFTDLPPNLYPTVGLQTPGEVVDANFGQHPFVFDIEDYMREWRTKIQAQIDRFPIGDREGEWQTMIQKMVSSYLVHHGYCATAEAFARSTDQTVLEELASIKNRQRIQKLVLAGRMGEAIETTQQLYPSLLERNPNLLFTLKVRQFIEMVNGTDSEVRCLGGRSPKSQDSYPVSPRPFSSPSMSPSHGMSIHSLAPGKSSTAHFSGFESCSNGVISNKAHQSYCHSKHQLSSLTVPELNSLNVSRSQQVNNFTSNDVDMETDHYSNGVGETSSNGFLNGSSKHDHEMEDCDTEMEVDCSQLRRQLCGGSQAAIERMIHFGRELQAMSEQLRRECGKNTANKKMLKDAFSLLAYSDPWNSPVGNQLDPIQREPVCSALNSAILETHNLPKQPPLALAMGQATQCLGLMARSGVGSCAFATVEDYLH
uniprot
proteins
function
FUNCTION: May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000250|UniProtKB:Q96S59}.
uniprot
proteins
mass_dalton
71012
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in response to stress. {ECO:0000250|UniProtKB:Q96S59}.; PTM: Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system (By similarity). {ECO:0000250|UniProtKB:Q96S59}.
uniprot
proteins
protein_family
RANBP9/10 family
uniprot
proteins
pubmed
12963025
uniprot
proteins
pubmed
14648869
uniprot
proteins
pubmed
14722085
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18710924
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28254886
uniprot
proteins
sequence_length
653
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18710924}. Cell membrane {ECO:0000305|PubMed:18710924}; Peripheral membrane protein {ECO:0000305|PubMed:18710924}; Cytoplasmic side {ECO:0000305|PubMed:18710924}. Nucleus {ECO:0000269|PubMed:18710924}. Note=Predominantly cytoplasmic (PubMed:18710924). A phosphorylated form is associated with the plasma membrane (By similarity). Perinuclear in spermatids (PubMed:14648869). {ECO:0000250|UniProtKB:Q96S59, ECO:0000269|PubMed:14648869, ECO:0000269|PubMed:18710924}.
uniprot
proteins