Bbs2
entrez
113948
canonical
uniprot
Q99MH9
canonical
ensembl
ENSRNOG00000019020
resolver
ensembl
ENSRNOG00055021525
resolver
ensembl
ENSRNOG00060015507
resolver
ensembl
ENSRNOG00065004017
resolver
ensp
ENSRNOP00000087643
resolver
ensp
ENSRNOP00055029858
resolver
ensp
ENSRNOP00060021225
resolver
ensp
ENSRNOP00065004209
resolver
enst
ENSRNOT00000106411
resolver
enst
ENSRNOT00055036769
resolver
enst
ENSRNOT00060026546
resolver
enst
ENSRNOT00065005854
resolver
genesymbol
Bbs2
resolver
uniprot
A0A8I6A3J2
resolver
uniprot_entry
A0A8I6A3J2_RAT
resolver
uniprot_entry
BBS2_RAT
resolver
amino_acid_sequence
MLLPVFTLKLRHKISPRMVAIGRYDGTHPCLAAATQAGKVFIHNPHMRSQHFSTSRVFQSPLESDVSLLNINQTVSCLGAGVLNPELGYDTLLVGTQTSLLAYDIYNNSDLFYREVADGANALVLGTLGDIAPPLAIIGGNCALQGFDHEGNDLFWTVTGDNVHSLALCDFDGDGKSELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTARYWRIKSKNHAMSIHAFDINSDGVCELITGWSNGKVDARSDRTGEVIFKDNFSSAVAGVVEGDYRMDGHVQLICCSVDGEIRGYLPGTAEMKGNLLDTSVEQGLIRELSQKKQNLLLELRNYEENTKAELSSPLNEADGQKGIIPANTKLHTALSVNLGNDAQDAHAELRISTSNDTIIRAVLIFAEGIFAGESHVVHPSTHNLSSSIRVPITPPKDVPVDLHLKTFVGYRSSTQFHVFELIRQLPRFTMYALTSPDAASEPVSFVNFIVVERAQRMVTWLNQNFLLPEDSNIQNAPFHVCFTSLRNGGQLYIKMKPSGEITVNTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELRKVLLKVDEYHSVHQKLSANMADNSNLIRSLLVRAEDARLMRDMKTMKTRYMELYDLNKDLLNGYKIRCNNHTELLGNLKAVNQAIQRAGRLRVGKPKNQVISACRDAIRSNNINTLFRIMRVGTAPS
uniprot
proteins
function
FUNCTION: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
79918
uniprot
proteins
pubmed
11285252
uniprot
proteins
sequence_length
721
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250}.
uniprot
proteins