Arglu1
entrez
234023
canonical
uniprot
Q3UL36
canonical
ensembl
ENSMUSG00000040459
resolver
ensp
ENSMUSP00000039493
resolver
genesymbol
Arglu1
resolver
uniprot
Q80XJ0
resolver
uniprot_entry
ARGL1_MOUSE
resolver
uniprot_sec
Q80XJ0
resolver
amino_acid_sequence
MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNAAASRRERERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD
uniprot
proteins
function
FUNCTION: Dual function regulator of gene expression; regulator of transcription and modulator of alternative splicing (PubMed:30698747). General coactivator of nuclear receptor-induced gene expression, including genes activated by the glucocorticoid receptor NR3C1 (PubMed:30698747). Binds to a subset of pre-mRNAs and to components of the spliceosome machinery to directly modulate basal alternative splicing; involved in simple and complex cassette exon splicing events (PubMed:30698747). Binds its own pre-mRNA and regulates its alternative splicing and degradation; one of the alternatively spliced products is a stable intronic sequence RNA (sisRNA) that binds the protein to regulate its ability to affect splicing (By similarity). Binding of the sisRNA stimulates phase separation and localization to nuclear speckles, which may contribute to activation of nuclear receptor-induced gene expression (By similarity). May also indirectly modulate alternative splicing (PubMed:30698747). Regulates transcription of genes involved in heart development, neuronal cell function, protein localization and chromatin localization (PubMed:30698747). Regulates splicing of genes involved in neurogenesis and chromatin organization (PubMed:30698747, PubMed:37612280). Essential for central nervous system development (PubMed:30698747, PubMed:37612280). Required for the estrogen-dependent expression of ESR1 target genes (By similarity). Can act in cooperation with MED1 (By similarity). {ECO:0000250|UniProtKB:Q9NWB6, ECO:0000269|PubMed:30698747, ECO:0000269|PubMed:37612280}.
uniprot
proteins
mass_dalton
32887
uniprot
proteins
protein_family
ARGLU1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
30698747
uniprot
proteins
pubmed
37612280
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30698747}. Nucleus speckle {ECO:0000269|PubMed:30698747}. Chromosome {ECO:0000269|PubMed:30698747}. Note=Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters (By similarity). Colocalizes with MED1 in nuclear speckles (By similarity). Binding of sisRNA promotes phase separation and localization to nuclear speckles (By similarity). Associated with glucocorticoid response elements of target genes, even in the absence of glucocorticoid receptor ligands (PubMed:30698747). {ECO:0000250|UniProtKB:Q9NWB6, ECO:0000269|PubMed:30698747}.
uniprot
proteins