Pbld
entrez
171564
canonical
uniprot
Q68G31
canonical
ensembl
ENSRNOG00000000386
resolver
ensembl
ENSRNOG00055009331
resolver
ensembl
ENSRNOG00060002916
resolver
ensembl
ENSRNOG00065023881
resolver
ensp
ENSRNOP00000000434
resolver
ensp
ENSRNOP00055012681
resolver
ensp
ENSRNOP00060003380
resolver
ensp
ENSRNOP00065033460
resolver
enst
ENSRNOT00055015801
resolver
enst
ENSRNOT00060004719
resolver
enst
ENSRNOT00065040979
resolver
genesymbol
Pbld
resolver
genesymbol_syn
Mawbp
resolver
uniprot
Q8R423
resolver
uniprot_entry
PBLD_RAT
resolver
uniprot_sec
Q8R423
resolver
amino_acid_sequence
MKLPIFIADAFTVTAFHGNPAAVCLLESILQEDAHQQIAREMNLSETAFIRKLQPTDSFSQSSCFGLRWFTPVSEVPLCGHATMASAAVLFHKIKNVNSTLTFVTLSGELKARRAEDGIVLDFPLYPTFPQDFHEVKDLIKAAIGDTTVQDIQYSPDTRKLLVRLSDSYDRSFLESLKVNTEPLPGIEKTGKVKGLILTVKGESGGQTTPYDFYSRYFAPWVGVPEDPVTGSAHTVLSSYWSQQLGKKEMRAFQCSCRGGELDISLRPDGRVDMKGGAAVVLEGMLTA
uniprot
proteins
function
FUNCTION: Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication. Enhances IRF3-mediated innate immune signaling and promotes apoptotic cell death, thereby suppressing viral replication. Facilitates virus-induced type I interferon (IFN-I) signaling by promoting IRF3 phosphorylation. Up-regulates the type I interferon (IFN-I) response by activating the NF-kappaB signaling pathway, potentially through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection. {ECO:0000250|UniProtKB:P30039}.
uniprot
proteins
mass_dalton
31687
uniprot
proteins
protein_family
PhzF family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
288
uniprot
proteins