SLC35D3
entrez
340146
canonical
uniprot
Q5M8T2
canonical
ensembl
ENSG00000182747
resolver
ensp
ENSP00000333591
resolver
enst
ENST00000331858
resolver
genesymbol
SLC35D3
resolver
genesymbol_syn
FRCL1
resolver
hgnc
HGNC:15621
resolver
uniprot
B4DI58
resolver
uniprot
B7Z9Y0
resolver
uniprot
Q5QNZ6
resolver
uniprot
Q6NX71
resolver
uniprot_entry
B7Z9Y0_HUMAN
resolver
uniprot_entry
S35D3_HUMAN
resolver
uniprot_sec
B4DI58
resolver
uniprot_sec
Q5QNZ6
resolver
uniprot_sec
Q6NX71
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by proton uncouplers that directly abolish the proton electrochemical gradient. {ECO:0000269|PubMed:34269178}.
uniprot
proteins
amino_acid_sequence
MRQLCRGRVLGISVAIAHGVFSGSLNILLKFLISRYQFSFLTLVQCLTSSTAALSLELLRRLGLIAVPPFGLSLARSFAGVAVLSTLQSSLTLWSLRGLSLPMYVVFKRCLPLVTMLIGVLVLKNGAPSPGVLAAVLITTCGAALAGAGDLTGDPIGYVTGVLAVLVHAAYLVLIQKASADTEHGPLTAQYVIAVSATPLLVICSFASTDSIHAWTFPGWKDPAMVCIFVACILIGCAMNFTTLHCTYINSAVTTSFVGVVKSIATITVGMVAFSDVEPTSLFIAGVVVNTLGSIIYCVAKFMETRKQSNYEDLEAQPRGEEAQLSGDQLPFVMEELPGEGGNGRSEGGEAAGGPAQESRQEVRGSPRGVPLVAGSSEEGSRRSLKDAYLEVWRLVRGTRYMKKDYLIENEELPSP
uniprot
proteins
function
FUNCTION: Probable UDP-glucose transmembrane transporter involved in UDP-glucose transport from the cytosol to the lumen of synaptic vesicles (PubMed:34269178). It is involved in platelet dense granules maturation (By similarity). {ECO:0000250|UniProtKB:Q8BGF8, ECO:0000269|PubMed:34269178}.; FUNCTION: Alternatively, could function as a molecular adapter enhancing the formation of the PI3KC3-C1/AIC/autophagy initiation complex to promote autophagy in dopaminergic neurons. Could also regulate the plasma membrane localization of the D(1A) dopamine receptor/DRD1 and dopamine signaling. {ECO:0000250|UniProtKB:Q8BGF8}.
uniprot
proteins
mass_dalton
44183
uniprot
proteins
protein_family
SLC35D subfamily
uniprot
proteins
protein_family
TPT transporter family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
34269178
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:34269178}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q8BGF8}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BGF8}; Multi-pass membrane protein {ECO:0000255}. Note=Active at early endosome membrane in the biosynthesis of mature platelet-dense granules. {ECO:0000250|UniProtKB:Q8BGF8}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 64..84; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 131..151; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 187..207; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 257..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 280..300; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins