Kcnj3
entrez
50599
canonical
uniprot
P63251
canonical
ensembl
ENSRNOG00000005369
resolver
ensembl
ENSRNOG00055000706
resolver
ensembl
ENSRNOG00060008163
resolver
ensembl
ENSRNOG00065008281
resolver
ensp
ENSRNOP00000007335
resolver
ensp
ENSRNOP00000082842
resolver
ensp
ENSRNOP00055000971
resolver
ensp
ENSRNOP00060010298
resolver
ensp
ENSRNOP00065009704
resolver
enst
ENSRNOT00000007335
resolver
enst
ENSRNOT00000116585
resolver
enst
ENSRNOT00055001216
resolver
enst
ENSRNOT00060013520
resolver
enst
ENSRNOT00065013133
resolver
genesymbol
Kcnj3
resolver
genesymbol_syn
Girk1
resolver
genesymbol_syn
Kga
resolver
uniprot
A0A8L2Q345
resolver
uniprot
P35562
resolver
uniprot_entry
A0A8L2Q345_RAT
resolver
uniprot_entry
KCNJ3_RAT
resolver
uniprot_sec
P35562
resolver
activity_regulation
ACTIVITY REGULATION: Heteromultimer composed of KCNJ3/GIRK1 and KCNJ5/GIRK4 is activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2). {ECO:0000269|PubMed:9486652}.
uniprot
proteins
amino_acid_sequence
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQGPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEVVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDISTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGPTRMEGNLPAKLRKMNSDRFT
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins (PubMed:8234283, PubMed:8355805, PubMed:9486652). This receptor plays a crucial role in regulating the heartbeat (PubMed:8234283). Forms a functional channel in association with KCNJ9/GIRK3 (PubMed:8670306). {ECO:0000269|PubMed:8234283, ECO:0000269|PubMed:8355805, ECO:0000269|PubMed:8670306, ECO:0000269|PubMed:9486652, ECO:0000303|PubMed:8234283}.
uniprot
proteins
mass_dalton
56573
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ3 subfamily
uniprot
proteins
pubmed
7704424
uniprot
proteins
pubmed
8234283
uniprot
proteins
pubmed
8355805
uniprot
proteins
pubmed
8642402
uniprot
proteins
pubmed
8670306
uniprot
proteins
pubmed
9486652
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 81..105; /note="Helical; Name=M1"; /evidence="ECO:0000250"; TRANSMEM 158..179; /note="Helical; Name=M2"; /evidence="ECO:0000250
uniprot
proteins