Cdk2ap2
entrez
52004
canonical
uniprot
Q9CPY4
canonical
ensembl
ENSMUSG00000024856
resolver
ensp
ENSMUSP00000025779
resolver
enst
ENSMUST00000025779
resolver
genesymbol
Cdk2ap2
resolver
genesymbol_syn
D19Ertd144e
resolver
genesymbol_syn
Doc1r
resolver
uniprot_entry
CDKA2_MOUSE
resolver
amino_acid_sequence
MSYKPIAPAPSSTPGSSTPGPGTPVPTAGSVPSPSGSVPGAAAPFRPLFNDFGPPSMGYVQAMKPPGSQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETERNART
uniprot
proteins
function
FUNCTION: Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (By similarity). Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs (PubMed:22548356). Regulates microtubule organization of metaphase II oocytes (PubMed:12944431). {ECO:0000250|UniProtKB:O75956, ECO:0000269|PubMed:12944431, ECO:0000269|PubMed:22548356}.
uniprot
proteins
mass_dalton
13202
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK1 and CDK2. {ECO:0000269|PubMed:12944431}.
uniprot
proteins
protein_family
CDK2AP family
uniprot
proteins
pubmed
12944431
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22548356
uniprot
proteins
sequence_length
127
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12944431}. Nucleus {ECO:0000269|PubMed:12944431}. Note=Accumulates in immature oocytes in the nucleus. During the first meiotic division, accumulates in the cytoplasm and localizes in dots in the vicinity of the chromosomes in a region enriched in microtubules. {ECO:0000269|PubMed:12944431}.
uniprot
proteins