Pola2
entrez
18969
canonical
uniprot
P33611
canonical
ensembl
ENSMUSG00000024833
resolver
ensp
ENSMUSP00000025752
resolver
ensp
ENSMUSP00000128866
resolver
ensp
ENSMUSP00000174642
resolver
ensp
ENSMUSP00000332781
resolver
enst
ENSMUST00000025752
resolver
enst
ENSMUST00000165143
resolver
genesymbol
Pola2
resolver
uniprot
F7B9W1
resolver
uniprot
Q8C2T6
resolver
uniprot
Q8VDR3
resolver
uniprot_entry
DPOA2_MOUSE
resolver
uniprot_entry
F7B9W1_MOUSE
resolver
uniprot_entry
Q8C2T6_MOUSE
resolver
uniprot_sec
Q8VDR3
resolver
amino_acid_sequence
MAVSTQQLAEELQIFGLDYEDSLLEKLAELCVLYRQTEDGMVSELIAFCTSAGKTCLTVDILNSFEYEVLNKKLSKAWHSASKDSGHAGTRDIVSIQELIEAEEEEETLLSSYTTPSKGPLKRVSSTPETPLTKRSVAARSPRQLLSPSSFSPSATPSQKYTSRTNRGEVVTTFGSAQGLSWSGRGGSGSVSLKVVGDPEPLTGSYKAMFQQLMGVREVLTSKIEELGSELKEHHKIEAFTPLLVPAQEPVILLGQIGCDSNGKLNSKSVILEGDQEHSYGAQIPVDLSELKEYSLFPGQVVIMEGFNTTGRRLTATKLYEGVPLPFYQPTEEEGASEQTMVVVACGPYTTSDSITYDPLLDLIAIINRDQPDVCILFGPFLDAKHEQVENCKLTSPFEDVFKQCLRTVIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFTFSELSREDKKRVQFVSEPCSLSINGVMFGLTSTDLLFHIGAEEIFSSSGTSDRFSRVLKHILTQRSYYPLYPPHEDMAIDYENFYTYAQLPVTPDVFIVPSELRYFVKDIFGCVCVNPGRLTKGQVGGTFGRLYLRRQPKAMDGGGRQGLSVAAQVVRI
uniprot
proteins
function
FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (By similarity). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerizing short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P20664, ECO:0000250|UniProtKB:Q14181}.
uniprot
proteins
mass_dalton
66214
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in a cell cycle-dependent manner, in G2/M phase. {ECO:0000250}.
uniprot
proteins
protein_family
DNA polymerase alpha subunit B family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8463324
uniprot
proteins
sequence_length
600
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins