TRIM9
entrez
114088
canonical
uniprot
Q9C026
canonical
ensembl
ENSG00000100505
resolver
ensp
ENSP00000298355
resolver
ensp
ENSP00000342970
resolver
ensp
ENSP00000353561
resolver
ensp
ENSP00000507131
resolver
ensp
ENSP00000580777
resolver
ensp
ENSP00000580778
resolver
ensp
ENSP00000580779
resolver
ensp
ENSP00000580780
resolver
ensp
ENSP00000580781
resolver
ensp
ENSP00000580782
resolver
ensp
ENSP00000580783
resolver
ensp
ENSP00000587933
resolver
ensp
ENSP00000638564
resolver
ensp
ENSP00000678354
resolver
enst
ENST00000684578
resolver
genesymbol
TRIM9
resolver
genesymbol_syn
KIAA0282
resolver
genesymbol_syn
RNF91
resolver
hgnc
HGNC:16288
resolver
uniprot
A0A804HIL7
resolver
uniprot
D3DSB7
resolver
uniprot
D3DSB8
resolver
uniprot
Q92557
resolver
uniprot
Q96D24
resolver
uniprot
Q96NI4
resolver
uniprot
Q9C025
resolver
uniprot
Q9C027
resolver
uniprot_entry
A0A804HIL7_HUMAN
resolver
uniprot_entry
TRIM9_HUMAN
resolver
uniprot_sec
D3DSB7
resolver
uniprot_sec
D3DSB8
resolver
uniprot_sec
Q92557
resolver
uniprot_sec
Q96D24
resolver
uniprot_sec
Q96NI4
resolver
uniprot_sec
Q9C025
resolver
uniprot_sec
Q9C027
resolver
amino_acid_sequence
MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELDDGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAFDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKNLTFFINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation (PubMed:20085810). Regulates filopodial dynamics in brain by promoting the ubiqutination and degradation of actin polymerase VASP; this activity is antagonized by TRIM67 (By similarity). May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. {ECO:0000250|UniProtKB:Q8C7M3, ECO:0000269|PubMed:20085810}.
uniprot
proteins
mass_dalton
79177
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:20085810}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. Poly-ubiquitinated in cultured cells, whereas it is monoubiquitinated in vitro (PubMed:20085810). {ECO:0000269|PubMed:20085810}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20085810
uniprot
proteins
pubmed
40821731
uniprot
proteins
pubmed
9179496
uniprot
proteins
sequence_length
710
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20085810}. Cell projection, dendrite {ECO:0000269|PubMed:20085810}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q91ZY8}. Synapse {ECO:0000250|UniProtKB:Q91ZY8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91ZY8}. Note=Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum (PubMed:20085810). {ECO:0000250|UniProtKB:Q91ZY8, ECO:0000269|PubMed:20085810}.
uniprot
proteins