Nmbr
entrez
25264
canonical
uniprot
P24053
canonical
ensembl
ENSRNOG00000012103
resolver
ensembl
ENSRNOG00055001740
resolver
ensembl
ENSRNOG00060005676
resolver
ensembl
ENSRNOG00065024358
resolver
ensp
ENSRNOP00000016215
resolver
ensp
ENSRNOP00055002099
resolver
ensp
ENSRNOP00060007101
resolver
ensp
ENSRNOP00065034151
resolver
enst
ENSRNOT00055002804
resolver
enst
ENSRNOT00060009434
resolver
enst
ENSRNOT00065041783
resolver
genesymbol
Nmbr
resolver
uniprot_entry
NMBR_RAT
resolver
amino_acid_sequence
MPPRSLPNLSLPTEASESELEPEVWENDFLPDSDGTTAELVIRCVIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHILYLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHFNSQLCCGQKSYPERSTSYLLSSSAVRMTSLKSNAKNVVTNSVLLNGHSTKQEIAL
uniprot
proteins
function
FUNCTION: Receptor for neuromedin-B (PubMed:1848080). Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (By similarity). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity). {ECO:0000250|UniProtKB:O54799, ECO:0000269|PubMed:1848080, ECO:0000269|PubMed:26855425}.
uniprot
proteins
mass_dalton
43535
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1848080
uniprot
proteins
pubmed
26855425
uniprot
proteins
pubmed
8391296
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..65; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 80..99; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 118..139; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 157..177; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 212..235; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 267..287; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 300..327; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins