Cd151
entrez
12476
canonical
uniprot
O35566
canonical
ensembl
ENSMUSG00000025510
resolver
ensp
ENSMUSP00000061636
resolver
ensp
ENSMUSP00000101622
resolver
ensp
ENSMUSP00000136331
resolver
enst
ENSMUST00000058746
resolver
enst
ENSMUST00000106000
resolver
enst
ENSMUST00000177840
resolver
genesymbol
Cd151
resolver
genesymbol_syn
Peta3
resolver
uniprot
O89118
resolver
uniprot_entry
CD151_MOUSE
resolver
uniprot_sec
O89118
resolver
amino_acid_sequence
MGEFNEKKATCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASSTYLATAYILVVAGVVVMVTGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYVYYQQLNTELKENLKDTMVKRYHQSGHEGVSSAVDKLQQEFHCCGSNNSQDWQDSEWIRSGEADSRVVPDSCCKTMVAGCGKRDHASNIYKVEGGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRSLKLEHY
uniprot
proteins
function
FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays a role in various cellular and molecular mechanism through its association with both integrin and non-integrin proteins. These interactions facilitate critical cellular functions, including cell-to-cell communication, wound healing, platelet aggregation, trafficking, cell motility, and angiogenesis (PubMed:15199151, PubMed:16410781). Via interaction with JAM-A/F11R and integrin ITGA3:ITGB1, promotes the recruitment of signaling molecules such as RAC1, CDC42 and RhoGTPases to facilitate the polarization of epithelial cells and the reorganization of the actin cytoskeleton, which are critical steps in cell migration process. Regulates the glycosylation pattern of ITGA3:ITGB1 thereby modulating its activity. Plays an essential role in the maintenance of central laminin-binding integrin ITGA6:ITGB4-containing adhesion complexes. Essential for the proper assembly of the glomerular and tubular basement membranes in kidney (PubMed:17015618). Contributes to T-cell activation by modulating integrin signaling leading to activation of downstream targets PTK2 and MAPK1/MAPK3. {ECO:0000250|UniProtKB:P48509, ECO:0000269|PubMed:15199151, ECO:0000269|PubMed:17015618}.
uniprot
proteins
mass_dalton
28246
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Palmitoylation by ZDHHC2 regulates CD151 expression, association with other tetraspanin family proteins and function in cell adhesion. {ECO:0000250|UniProtKB:P48509}.; PTM: Ubiquitinated by RNF128 on lysine residues present in the tetraspanin amino terminus via 'Lys-48'-linked ubiquitin leading to proteasomal degradation. {ECO:0000250|UniProtKB:P48509}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
15199151
uniprot
proteins
pubmed
16410781
uniprot
proteins
pubmed
17015618
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9294006
uniprot
proteins
pubmed
9602068
uniprot
proteins
sequence_length
253
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P48509}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48509}. Note=Relocalizes to the immune synapse in T-cells upon activation. {ECO:0000250|UniProtKB:P48509}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 58..78; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 222..242; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins