THBS2
entrez
7058
canonical
uniprot
P35442
canonical
ensembl
ENSG00000186340
resolver
ensp
ENSP00000355751
resolver
ensp
ENSP00000482784
resolver
ensp
ENSP00000503020
resolver
ensp
ENSP00000504416
resolver
ensp
ENSP00000504820
resolver
ensp
ENSP00000576063
resolver
ensp
ENSP00000576064
resolver
ensp
ENSP00000639695
resolver
ensp
ENSP00000639698
resolver
ensp
ENSP00000693643
resolver
enst
ENST00000366787
resolver
enst
ENST00000617924
resolver
enst
ENST00000676498
resolver
enst
ENST00000676628
resolver
enst
ENST00000676760
resolver
enst
ENST00000906004
resolver
enst
ENST00000906005
resolver
enst
ENST00000969636
resolver
enst
ENST00000969639
resolver
genesymbol
THBS2
resolver
genesymbol_syn
TSP2
resolver
hgnc
HGNC:11786
resolver
uniprot
A0A7I2V585
resolver
uniprot
A6H8N1
resolver
uniprot
A7E232
resolver
uniprot
Q5RI52
resolver
uniprot_entry
A0A7I2V585_HUMAN
resolver
uniprot_entry
TSP2_HUMAN
resolver
uniprot_sec
A6H8N1
resolver
uniprot_sec
A7E232
resolver
uniprot_sec
Q5RI52
resolver
amino_acid_sequence
MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRFDYIPPVNADDLSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGPADTLDLTYWIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFYEHLQAEKSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGCQQGQGAEINAISENTETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQELSGLHVLVNQLSENLKRVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDDDNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI
uniprot
proteins
disease_involvement
DISEASE: Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. {ECO:0000269|PubMed:18455130}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Ehlers-Danlos syndrome, classic-like, 3 (EDSCLL3) [MIM:620865]: A form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. EDSCLL3 is an autosomal dominant form. Affected individuals have joint hypermobility, frequent joint dislocations, atrophic scarring, prolonged bleeding time and age-related aortic dilatation and rupture. {ECO:0000269|PubMed:38433265}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. {ECO:0000269|PubMed:20714802}.
uniprot
proteins
mass_dalton
129991
uniprot
proteins
mutagenesis
MUTAGEN 702; /note="N->S: Alters protein stability."; /evidence="ECO:0000269|PubMed:18499674
uniprot
proteins
protein_family
Thrombospondin family
uniprot
proteins
pubmed
11590138
uniprot
proteins
pubmed
1371676
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1559694
uniprot
proteins
pubmed
16186819
uniprot
proteins
pubmed
18455130
uniprot
proteins
pubmed
18499674
uniprot
proteins
pubmed
20714802
uniprot
proteins
pubmed
38433265
uniprot
proteins
pubmed
8406456
uniprot
proteins
sequence_length
1172
uniprot
proteins