LAMTOR5
entrez
10542
canonical
uniprot
O43504
canonical
ensembl
ENSG00000134248
resolver
ensp
ENSP00000256644
resolver
ensp
ENSP00000473439
resolver
enst
ENST00000256644
resolver
enst
ENST00000602318
resolver
genesymbol
LAMTOR5
resolver
genesymbol_syn
HBXIP
resolver
genesymbol_syn
XIP
resolver
hgnc
HGNC:17955
resolver
uniprot
A0A0C4DGV4
resolver
uniprot
A0A8Z5A536
resolver
uniprot
Q6IBD8
resolver
uniprot_entry
A0A8Z5A536_HUMAN
resolver
uniprot_entry
LTOR5_HUMAN
resolver
uniprot_sec
A0A0C4DGV4
resolver
uniprot_sec
Q6IBD8
resolver
amino_acid_sequence
MEATLEQHLEDTMKNPSIVGVLCTDSQGLNLGCRGTLSDEHAGVISVLAQQAAKLTSDPTDIPVVCLESDNGNIMIQKHDGITVAVHKMAS
uniprot
proteins
function
FUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:22980980, PubMed:29158492, PubMed:30181260). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22053050, PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29158492, PubMed:30181260). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:22980980, PubMed:29158492, PubMed:30181260). When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway (PubMed:12773388). {ECO:0000269|PubMed:12773388, ECO:0000269|PubMed:22053050, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:30181260}.
uniprot
proteins
mass_dalton
9614
uniprot
proteins
mutagenesis
MUTAGEN 12; /note="T->A: No change."; /evidence="ECO:0000269|PubMed:9499022"; MUTAGEN 36; /note="T->A: No interaction with XABX14-154 (truncated form of HBX)."; /evidence="ECO:0000269|PubMed:9499022
uniprot
proteins
protein_family
LAMTOR5 family
uniprot
proteins
pubmed
12773388
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16176273
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21059355
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22053050
uniprot
proteins
pubmed
22980980
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25561175
uniprot
proteins
pubmed
25567906
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28935770
uniprot
proteins
pubmed
29107538
uniprot
proteins
pubmed
29123114
uniprot
proteins
pubmed
29158492
uniprot
proteins
pubmed
29285400
uniprot
proteins
pubmed
30181260
uniprot
proteins
pubmed
31314152
uniprot
proteins
pubmed
31601708
uniprot
proteins
pubmed
31672913
uniprot
proteins
pubmed
31704029
uniprot
proteins
pubmed
32868926
uniprot
proteins
pubmed
35338845
uniprot
proteins
pubmed
36103527
uniprot
proteins
pubmed
36697823
uniprot
proteins
pubmed
9499022
uniprot
proteins
sequence_length
91
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:22980980}. Cytoplasm, cytosol {ECO:0000269|PubMed:12773388}.
uniprot
proteins