MED23
entrez
9439
canonical
uniprot
Q9ULK4
canonical
ensembl
ENSG00000112282
resolver
ensp
ENSP00000346588
resolver
ensp
ENSP00000357032
resolver
ensp
ENSP00000357037
resolver
ensp
ENSP00000357039
resolver
ensp
ENSP00000357047
resolver
ensp
ENSP00000656127
resolver
genesymbol
MED23
resolver
genesymbol_syn
ARC130
resolver
genesymbol_syn
CRSP3
resolver
genesymbol_syn
DRIP130
resolver
genesymbol_syn
KIAA1216
resolver
genesymbol_syn
SUR2
resolver
hgnc
HGNC:2372
resolver
uniprot
B9TX55
resolver
uniprot
O95403
resolver
uniprot
Q05DL5
resolver
uniprot
Q5JWT3
resolver
uniprot
Q5JWT4
resolver
uniprot
Q6P9H6
resolver
uniprot
Q9H0J2
resolver
uniprot
Q9NTT9
resolver
uniprot
Q9NTU0
resolver
uniprot
Q9Y5P7
resolver
uniprot
Q9Y667
resolver
uniprot_entry
MED23_HUMAN
resolver
uniprot_entry
Q05DL5_HUMAN
resolver
uniprot_sec
B9TX55
resolver
uniprot_sec
O95403
resolver
uniprot_sec
Q5JWT3
resolver
uniprot_sec
Q5JWT4
resolver
uniprot_sec
Q6P9H6
resolver
uniprot_sec
Q9H0J2
resolver
uniprot_sec
Q9NTT9
resolver
uniprot_sec
Q9NTU0
resolver
uniprot_sec
Q9Y5P7
resolver
uniprot_sec
Q9Y667
resolver
amino_acid_sequence
METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLRLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAMNSGSPAPQSNQVPVSLPVTQ
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, autosomal recessive 18, with or without epilepsy (MRT18) [MIM:614249]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269|PubMed:21868677}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000250, ECO:0000269|PubMed:10353252, ECO:0000269|PubMed:14759369, ECO:0000269|PubMed:16595664}.
uniprot
proteins
mass_dalton
156474
uniprot
proteins
protein_family
Mediator complex subunit 23 family
uniprot
proteins
pubmed
10235266
uniprot
proteins
pubmed
10235267
uniprot
proteins
pubmed
10353252
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
10993082
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11867769
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14759369
uniprot
proteins
pubmed
15175163
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15989967
uniprot
proteins
pubmed
16595664
uniprot
proteins
pubmed
17000779
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20111005
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21868677
uniprot
proteins
pubmed
9989412
uniprot
proteins
sequence_length
1368
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins