Pak3
entrez
18481
canonical
uniprot
Q61036
canonical
ensembl
ENSMUSG00000031284
resolver
ensp
ENSMUSP00000033640
resolver
ensp
ENSMUSP00000108484
resolver
ensp
ENSMUSP00000108485
resolver
ensp
ENSMUSP00000126562
resolver
ensp
ENSMUSP00000171261
resolver
ensp
ENSMUSP00000171262
resolver
ensp
ENSMUSP00000171264
resolver
ensp
ENSMUSP00000171265
resolver
ensp
ENSMUSP00000171266
resolver
ensp
ENSMUSP00000171275
resolver
ensp
ENSMUSP00000171277
resolver
ensp
ENSMUSP00000171281
resolver
ensp
ENSMUSP00000171282
resolver
ensp
ENSMUSP00000171283
resolver
ensp
ENSMUSP00000171285
resolver
ensp
ENSMUSP00000171289
resolver
ensp
ENSMUSP00000171290
resolver
ensp
ENSMUSP00000171292
resolver
ensp
ENSMUSP00000171294
resolver
genesymbol
Pak3
resolver
genesymbol_syn
Pak-3
resolver
genesymbol_syn
Pakb
resolver
genesymbol_syn
Stk4
resolver
uniprot
B1GX80
resolver
uniprot
B1GX81
resolver
uniprot
O88645
resolver
uniprot
Q8K1R5
resolver
uniprot
Q8K1R6
resolver
uniprot_entry
B1GX80_MOUSE
resolver
uniprot_entry
B1GX81_MOUSE
resolver
uniprot_entry
PAK3_MOUSE
resolver
uniprot_sec
O88645
resolver
uniprot_sec
Q8K1R5
resolver
uniprot_sec
Q8K1R6
resolver
activity_regulation
ACTIVITY REGULATION: Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-436 and allows the kinase domain to adopt an active structure (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MSDSLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHQSNTKTASEPPLAPPVSEEEDEEEEEEEDDNEPPPVIAPRPEHTKSIYTRSVVESIASPAAPNKEDIPPSAENANSTTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNSSR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity (PubMed:25851601). Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (PubMed:15800193). {ECO:0000269|PubMed:12242269, ECO:0000269|PubMed:15574732, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:17537723, ECO:0000269|PubMed:20540949, ECO:0000269|PubMed:25851601}.
uniprot
proteins
mass_dalton
62398
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="R->C: Decreases interaction of PAK3 with CDC42 but increases interaction with RAC1."; /evidence="ECO:0000269|PubMed:17537723"; MUTAGEN 78; /note="H->L: When expressed in hippocampal neurons, strongly decreases the number of dendritic spines; when associated with L-81 and R-312."; /evidence="ECO:0000269|PubMed:15800193"; MUTAGEN 81; /note="H->L: When expressed in hippocampal neurons, strongly decreases the number of dendritic spines; when associated with L-78 and R-312."; /evidence="ECO:0000269|PubMed:15800193"; MUTAGEN 312; /note="K->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15574732"; MUTAGEN 312; /note="K->R: When expressed in hippocampal neurons, decreases the number of dendritic spines. Strong decrease in the number of dendritic spines; when associated with L-78 and L-81."; /evidence="ECO:0000269|PubMed:15800193"; MUTAGEN 436; /note="T->E: When expressed in hippocampal neurons, increases the density of both spines and dendritic protrusions."; /evidence="ECO:0000269|PubMed:15800193
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated when activated by CDC42/p21.; PTM: Neddylated. {ECO:0000250}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
10352232
uniprot
proteins
pubmed
10747784
uniprot
proteins
pubmed
12242269
uniprot
proteins
pubmed
12464619
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15574732
uniprot
proteins
pubmed
15800193
uniprot
proteins
pubmed
16014725
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17537723
uniprot
proteins
pubmed
20540949
uniprot
proteins
pubmed
21115725
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25851601
uniprot
proteins
pubmed
7559398
uniprot
proteins
sequence_length
559
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins