Fzd8
entrez
14370
canonical
uniprot
Q61091
canonical
ensembl
ENSMUSG00000036904
resolver
ensp
ENSMUSP00000039660
resolver
enst
ENSMUST00000041080
resolver
genesymbol
Fzd8
resolver
uniprot
A2RTK9
resolver
uniprot_entry
FZD8_MOUSE
resolver
uniprot_sec
A2RTK9
resolver
amino_acid_sequence
MEWGYLLEVTSLLAALAVLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPPGEQPPSGSGHSRPPGARPPHRGGSSRGSGDAAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAAGAGAAGAGASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRALCTRCCWASKGAAVGAGAGGSGPGGSGPGPGGGGGHGGGGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (By similarity). The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. {ECO:0000250, ECO:0000269|PubMed:10097073, ECO:0000269|PubMed:10395542, ECO:0000269|PubMed:15454084, ECO:0000269|PubMed:16543246}.
uniprot
proteins
mass_dalton
73045
uniprot
proteins
mutagenesis
MUTAGEN 685; /note="V->A: Reduces interaction with GOPC."; /evidence="ECO:0000269|PubMed:11520064
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
10097073
uniprot
proteins
pubmed
10395542
uniprot
proteins
pubmed
11452312
uniprot
proteins
pubmed
11520064
uniprot
proteins
pubmed
15454084
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16543246
uniprot
proteins
pubmed
22653731
uniprot
proteins
pubmed
8626800
uniprot
proteins
sequence_length
685
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Golgi apparatus. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with GOPC at the Golgi apparatus.
uniprot
proteins
transmembrane_region
TRANSMEM 273..293; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 310..330; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 395..415; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 438..458; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 482..502; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 531..551; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 583..603; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins