Defb1
entrez
13214
canonical
uniprot
P56386
canonical
ensembl
ENSMUSG00000044748
resolver
ensp
ENSMUSP00000051754
resolver
enst
ENSMUST00000051017
resolver
genesymbol
Defb1
resolver
uniprot
Q3UQE2
resolver
uniprot_entry
DEFB1_MOUSE
resolver
uniprot_entry
Q3UQE2_MOUSE
resolver
amino_acid_sequence
MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS
uniprot
proteins
function
FUNCTION: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. {ECO:0000250|UniProtKB:P60022}.
uniprot
proteins
mass_dalton
7749
uniprot
proteins
protein_family
Beta-defensin family
uniprot
proteins
pubmed
10922379
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9287114
uniprot
proteins
sequence_length
69
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60022}. Membrane {ECO:0000250|UniProtKB:P60022}. Note=Associates with tumor cell membrane-derived microvesicles. {ECO:0000250|UniProtKB:P60022}.
uniprot
proteins