Smpdl3a
entrez
294422
canonical
uniprot
Q641Z7
canonical
ensembl
ENSRNOG00000066945
resolver
ensembl
ENSRNOG00055014438
resolver
ensembl
ENSRNOG00060007824
resolver
ensembl
ENSRNOG00065003230
resolver
ensp
ENSRNOP00000105296
resolver
ensp
ENSRNOP00055020260
resolver
ensp
ENSRNOP00060009778
resolver
ensp
ENSRNOP00065003275
resolver
enst
ENSRNOT00000113155
resolver
enst
ENSRNOT00055024783
resolver
enst
ENSRNOT00060012902
resolver
enst
ENSRNOT00065004574
resolver
genesymbol
Smpdl3a
resolver
genesymbol_syn
Asml3a
resolver
uniprot_entry
ASM3A_RAT
resolver
amino_acid_sequence
MALPGNFLCCLLVAWLCDPGLGVPLAPAYGAPAVGQFWHVTDLHLDPTYHITDDHTKVCASSKGANVSNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVRELSTGSVIEVITNMTVTVQNLFPNLQVFPALGNHDYWPQDQLPIATSKVYSAVSDLWKPWLDEEAISTLRKGGFYSQKVASNPDLRIISLNTNLYYGPNIMTLNKTDPANQFEWLENTLNSSLRNKEKVYVIAHVPVGYLPYATKTPAMRQYYNEKLVDIFRRYSSVIAGQFYGHTHRDSLMVLSDKNGNPINSVFVAPAVTPVKGVLEKETNNPGVRLFQYKPGDYTLLDMLQYYLNLTEANLKGESNWTLEYTLTQAYGVADLQPKSLHGLAQQLATIDSKQFLKYYHYFFVSYDSSAPCDQRCKTLQICAIMNLDLVSYEDCLKRHL
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
ec_number
3.6.1.15
uniprot
proteins
function
FUNCTION: Cyclic-nucleotide phosphodiesterase that acts as a negative regulator of innate immunity by mediating degradation of 2',3'-cGAMP, thereby inhibiting the cGAS-STING signaling. Specifically linearizes 2',3'-cGAMP into 2'5'-bond pGpA and further hydrolyzes pGpA to produce GpA. Also has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity. {ECO:0000250|UniProtKB:Q92484}.
uniprot
proteins
mass_dalton
49896
uniprot
proteins
protein_family
Acid sphingomyelinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q92484}.
uniprot
proteins