FOXM1
entrez
2305
canonical
uniprot
Q08050
canonical
ensembl
ENSG00000111206
resolver
ensp
ENSP00000342307
resolver
ensp
ENSP00000352901
resolver
ensp
ENSP00000354492
resolver
ensp
ENSP00000486536
resolver
ensp
ENSP00000535690
resolver
ensp
ENSP00000535691
resolver
ensp
ENSP00000535692
resolver
ensp
ENSP00000587243
resolver
ensp
ENSP00000587244
resolver
ensp
ENSP00000587245
resolver
ensp
ENSP00000587248
resolver
ensp
ENSP00000587249
resolver
ensp
ENSP00000587255
resolver
ensp
ENSP00000732801
resolver
ensp
ENSP00000732802
resolver
ensp
ENSP00000732803
resolver
ensp
ENSP00000732804
resolver
ensp
ENSP00000732806
resolver
ensp
ENSP00000732808
resolver
ensp
ENSP00000732811
resolver
enst
ENST00000627656
resolver
genesymbol
FOXM1
resolver
genesymbol_syn
FKHL16
resolver
genesymbol_syn
HFH11
resolver
genesymbol_syn
MPP2
resolver
genesymbol_syn
WIN
resolver
hgnc
HGNC:3818
resolver
uniprot
A0A0D9SFF0
resolver
uniprot
A0A2P9DTZ0
resolver
uniprot
A0A2P9DTZ1
resolver
uniprot
A0A2P9DTZ8
resolver
uniprot
A8K591
resolver
uniprot
O43258
resolver
uniprot
O43259
resolver
uniprot
O43260
resolver
uniprot
Q4ZGG7
resolver
uniprot
Q53Y49
resolver
uniprot
Q9BRL2
resolver
uniprot_entry
A0A0D9SFF0_HUMAN
resolver
uniprot_entry
A0A2P9DTZ1_HUMAN
resolver
uniprot_entry
A0A2P9DTZ8_HUMAN
resolver
uniprot_entry
A8K591_HUMAN
resolver
uniprot_entry
FOXM1_HUMAN
resolver
uniprot_entry
Q53Y49_HUMAN
resolver
uniprot_sec
A0A2P9DTZ0
resolver
uniprot_sec
O43258
resolver
uniprot_sec
O43259
resolver
uniprot_sec
O43260
resolver
uniprot_sec
Q4ZGG7
resolver
uniprot_sec
Q9BRL2
resolver
amino_acid_sequence
MKTSPRRPLILKRRRLPLPVQNAPSETSEEEPKRSPAQQESNQAEASKEVAESNSCKFPAGIKIINHPTMPNTQVVAIPNNANIHSIITALTAKGKESGSSGPNKFILISCGGAPTQPPGLRPQTQTSYDAKRTEVTLETLGPKPAARDVNLPRPPGALCEQKRETCADGEAAGCTINNSLSNIQWLRKMSSDGLGSRSIKQEMEEKENCHLEQRQVKVEEPSRPSASWQNSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRYLTLDQVFKPLDPGSPQLPEHLESQQKRPNPELRRNMTIKTELPLGARRKMKPLLPRVSSYLVPIQFPVNQSLVLQPSVKVPLPLAASLMSSELARHSKRVRIAPKVLLAEEGIAPLSSAGPGKEEKLLFGEGFSPLLPVQTIKEEEIQPGEEMPHLARPIKVESPPLEEWPSPAPSFKEESSHSWEDSSQSPTPRPKKSYSGLRSPTRCVSEMLVIQHRERRERSRSRRKQHLLPPCVDEPELLFSEGPSTSRWAAELPFPADSSDPASQLSYSQEVGGPFKTPIKETLPISSTPSKSVLPRTPESWRLTPPAKVGGLDFSPVQTSQGASDPLPDPLGLMDLSTTPLQSAPPLESPQRLLSSEPLDLISVPFGNSSPSDIDVPKPGSPEPQVSGLAANRSLTEGLVLDTMNDSLSKILLDISFPGLDEDPLGPDNINWSQFIPELQ
uniprot
proteins
function
FUNCTION: Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}.; FUNCTION: [Isoform 5]: Required for the activation of Rho-associated protein kinases ROCK1 and ROCK2 and promotes epithelial-mesenchymal transition (PubMed:27399334). Enhances the activation of phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) by binding simultaneously to the catalytic and regulatory subunits (PubMed:32606397). This relieves the inhibitory effect of the regulatory subunit on the kinase activity of the catalytic subunit, resulting in downstream signaling events such as AKT activation, GSK3B inactivation, and increased levels of SNAI1 (PubMed:32606397). Promotes glycolysis by binding to the pyruvate kinase PKM homotetramer to form a heterooctamer, inhibiting PKM activity (PubMed:33314660). Promotes the IMP4-mediated nuclear translocation of both PKM and the NF-kappa-B complex which increases transcription of VEGFA, leading to increased angiogenesis (PubMed:33314660). {ECO:0000269|PubMed:27399334, ECO:0000269|PubMed:32606397, ECO:0000269|PubMed:33314660}.
uniprot
proteins
mass_dalton
84283
uniprot
proteins
mutagenesis
MUTAGEN 489; /note="S->A: Prevents phosphorylation by GSK3 and subsequent ubiquitination."; /evidence="ECO:0000269|PubMed:26912724"; MUTAGEN 611; /note="T->A: Prevents phosphorylation by CDK1 and subsequent binding of POLO box domains of PLK1; when associated with A-693."; /evidence="ECO:0000269|PubMed:19160488"; MUTAGEN 693; /note="S->A: Prevents phosphorylation by CDK1 and subsequent binding of POLO box domains of PLK1; when associated with A-611."; /evidence="ECO:0000269|PubMed:19160488"; MUTAGEN 730; /note="S->A: Prevents phosphorylation by PLK1 and impairs transcription activity; when associated with A-739."; /evidence="ECO:0000269|PubMed:19160488"; MUTAGEN 739; /note="S->A: Prevents phosphorylation by PLK1 and impairs transcription activity; when associated with A-730."; /evidence="ECO:0000269|PubMed:19160488
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in M (mitotic) phase (PubMed:17101782, PubMed:19160488, PubMed:30139873). Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair (PubMed:17101782). Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1 (PubMed:19160488, PubMed:30139873). Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators (PubMed:19160488). Phosphorylated by GSK3B leading to ubiquitination and proteasomal degradation (PubMed:26912724). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:30139873}.; PTM: Ubiquitinated in a FBXW7-dependent manner leading to proteasomal degradation. {ECO:0000269|PubMed:26912724}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17101782
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19160488
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20360045
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
26912724
uniprot
proteins
pubmed
27399334
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
30139873
uniprot
proteins
pubmed
32606397
uniprot
proteins
pubmed
33314660
uniprot
proteins
pubmed
33754036
uniprot
proteins
pubmed
8290587
uniprot
proteins
pubmed
9032290
uniprot
proteins
pubmed
9242644
uniprot
proteins
sequence_length
763
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:33314660}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:27399334, ECO:0000269|PubMed:33314660}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:33314660}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:27399334, ECO:0000269|PubMed:32606397, ECO:0000269|PubMed:33314660}.
uniprot
proteins