Arhgef2
entrez
16800
canonical
uniprot
Q60875
canonical
ensembl
ENSMUSG00000028059
resolver
ensp
ENSMUSP00000029694
resolver
ensp
ENSMUSP00000103134
resolver
ensp
ENSMUSP00000127843
resolver
ensp
ENSMUSP00000134834
resolver
ensp
ENSMUSP00000134840
resolver
ensp
ENSMUSP00000135168
resolver
ensp
ENSMUSP00000135177
resolver
ensp
ENSMUSP00000319338
resolver
enst
ENSMUST00000175779
resolver
enst
ENSMUST00000176500
resolver
enst
ENSMUST00000177498
resolver
genesymbol
Arhgef2
resolver
genesymbol_syn
Kiaa0651
resolver
genesymbol_syn
Lbcl1
resolver
genesymbol_syn
Lfc
resolver
uniprot
E9QNW9
resolver
uniprot
H3BJ40
resolver
uniprot
H3BJ45
resolver
uniprot
O09115
resolver
uniprot
Q3TBI4
resolver
uniprot
Q3TJ16
resolver
uniprot
Q8CHE1
resolver
uniprot
Q923E0
resolver
uniprot
Q9ESG7
resolver
uniprot_entry
ARHG2_MOUSE
resolver
uniprot_entry
H3BJ40_MOUSE
resolver
uniprot_entry
H3BJ45_MOUSE
resolver
uniprot_sec
E9QNW9
resolver
uniprot_sec
O09115
resolver
uniprot_sec
Q3TBI4
resolver
uniprot_sec
Q3TJ16
resolver
uniprot_sec
Q8CHE1
resolver
uniprot_sec
Q923E0
resolver
uniprot_sec
Q9ESG7
resolver
amino_acid_sequence
MSRIESLTRARIDRSKEQATKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLRNNTALQSVSLRSKTTTRERPTSAIYPSDSFRQSLLGSRRGLSSLSLAKSVSTTNIAGHFNDESPLGLRQILSQSTDSLNMRNRTLSVESLIDEGVEVFYNELMSDFEMDEKDFEADSWSLAVDSSFLQQHKKEVMKKQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELQMEPEVVQGLFPCVDELSDIHTRFLNQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGSNAEQMRKTYSEFCSRHTKALKLYKELYARDKRFQQFIRKMTRSAVLKRHGVQECILLVTQRITKYPVLINRILQNSHGVEEEYQDLASALGLVKELLSNVDQDVHELEKEARLQEIYNRMDPRAQTPVPGKGPFGRDELLRRKLIHEGCLLWKTATGRFKDVLLLLMTDVLVFLQEKDQKYIFTSLDKPSVVSLQNLIVRDIANQAKGMFLISSGPPEMYEVHAASRDDRTTWIRVIQQSVRLCPSREDFPLIETEDKAYLRRIKTKLQQKNQALVELLQKNVELFAEMVHFQALKAGFVGMPPPALPRGLFRLESFESLRGERLLKDALREVEGLKDLLLGPCVDLPMTSREPALPLDSDSGSCPGVTANGEARTFNGSIELCRADSDSSQKDRNGNQLRSPQEEVLQPLINLYGLLHGLQAVVVQQERLMEALFPEGPERWEKLSRANSRDGEAGRAAVASVTPEKQATELALLQRQHTLLQEELRRCQRLGEERATEAGSLEARLRESEQARALLEREAEEIRRQLAALGQNEPLPAEAPWARRPLDPRRRSLPAGDALYLSFNPPQPSRGHDRLDLPVTVRSLHRPFDDREAQELGSPEDRLQDSSDPDTGSEEEVSSRLSPPHSPRDFTRMQDIPEETESRDGEPTASES
uniprot
proteins
function
FUNCTION: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (PubMed:28453519). {ECO:0000250|UniProtKB:Q865S3, ECO:0000250|UniProtKB:Q92974, ECO:0000269|PubMed:28453519}.
uniprot
proteins
mass_dalton
111974
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-885 by PAK1 induces binding to protein YWHAZ, promoting its relocation to microtubules and the inhibition of its activity. Phosphorylated by AURKA and CDK1 during mitosis, which negatively regulates its activity. Phosphorylation by MAPK1 or MAPK3 increases nucleotide exchange activity. Phosphorylation by PAK4 releases GEF-H1 from the microtubules. Phosphorylated on serine, threonine and tyrosine residues in a RIPK2-dependent manner (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
12465718
uniprot
proteins
pubmed
12604587
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18394899
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21406564
uniprot
proteins
pubmed
28453519
uniprot
proteins
pubmed
7629163
uniprot
proteins
sequence_length
985
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q865S3, ECO:0000250|UniProtKB:Q92974}. Cytoplasm {ECO:0000250|UniProtKB:Q865S3, ECO:0000250|UniProtKB:Q92974}. Cell junction, tight junction {ECO:0000269|PubMed:12604587}. Golgi apparatus {ECO:0000250|UniProtKB:Q92974}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q865S3, ECO:0000250|UniProtKB:Q92974}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q92974}. Note=Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization (By similarity). Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton (By similarity). Associated with apical intercellular junctions in the trophectoderm of the blastocyst (PubMed:12604587). {ECO:0000250|UniProtKB:Q92974, ECO:0000269|PubMed:12604587}.
uniprot
proteins