Ptpa
entrez
110854
canonical
uniprot
P58389
canonical
ensembl
ENSMUSG00000039515
resolver
ensp
ENSMUSP00000046837
resolver
ensp
ENSMUSP00000227435
resolver
ensp
ENSMUSP00000227438
resolver
enst
ENSMUST00000042055
resolver
genesymbol
Ptpa
resolver
genesymbol_syn
Ppp2r4
resolver
uniprot
Q543N6
resolver
uniprot_entry
PTPA_MOUSE
resolver
uniprot_entry
Q543N6_MOUSE
resolver
amino_acid_sequence
MAEGERQPPPDSSEETPPTTQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFDYKVSEAIEKLVALLDTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDQEAENLVATVVPTHLAAAVPEVAVYLKEAVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQVAIVFKVFDRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIDHPHLEPRHFVDEKAVSENHKDYMFLQCILFITEMKTGPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVTSG
uniprot
proteins
ec_number
5.2.1.8
uniprot
proteins
function
FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) (By similarity). Modulates PP2A activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase (By similarity). Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro) (By similarity). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex (By similarity). Is involved in apoptosis; the function appears to be independent from PP2A (By similarity). {ECO:0000250|UniProtKB:Q15257, ECO:0000250|UniProtKB:Q28717}.
uniprot
proteins
mass_dalton
36710
uniprot
proteins
protein_family
PTPA-type PPIase family
uniprot
proteins
pubmed
12952889
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15257}. Nucleus {ECO:0000250|UniProtKB:Q15257}.
uniprot
proteins