H2BC5
entrez
3017
canonical
uniprot
P58876
canonical
ensembl
ENSG00000158373
resolver
ensp
ENSP00000289316
resolver
ensp
ENSP00000367008
resolver
ensp
ENSP00000560851
resolver
ensp
ENSP00000609457
resolver
ensp
ENSP00000609458
resolver
enst
ENST00000289316
resolver
enst
ENST00000377777
resolver
enst
ENST00000890792
resolver
enst
ENST00000939398
resolver
enst
ENST00000939399
resolver
genesymbol
H2BC5
resolver
genesymbol_syn
H2BFB
resolver
genesymbol_syn
HIRIP2
resolver
genesymbol_syn
HIST1H2BD
resolver
hgnc
HGNC:4747
resolver
uniprot_entry
H2B1D_HUMAN
resolver
amino_acid_sequence
MPEPTKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
uniprot
proteins
function
FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
uniprot
proteins
mass_dalton
13936
uniprot
proteins
post_translational_modification
PTM: Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons. {ECO:0000269|PubMed:16627869}.; PTM: Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:12757711). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination. {ECO:0000250|UniProtKB:Q64475, ECO:0000269|PubMed:12757711}.; PTM: GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity). {ECO:0000250|UniProtKB:P62807}.; PTM: ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (PubMed:27723750, PubMed:34874266). H2BS6ADPr promotes recruitment of CHD1L (PubMed:34874266). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (PubMed:27530147). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). {ECO:0000250|UniProtKB:Q6ZWY9, ECO:0000269|PubMed:27530147, ECO:0000269|PubMed:27723750, ECO:0000269|PubMed:34874266}.; PTM: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. {ECO:0000269|PubMed:21925322}.; PTM: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. {ECO:0000269|PubMed:31645732}.
uniprot
proteins
protein_family
Histone H2B family
uniprot
proteins
pubmed
12408966
uniprot
proteins
pubmed
12757711
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16283522
uniprot
proteins
pubmed
16307923
uniprot
proteins
pubmed
16319397
uniprot
proteins
pubmed
16457587
uniprot
proteins
pubmed
16627869
uniprot
proteins
pubmed
16713563
uniprot
proteins
pubmed
1916825
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21726816
uniprot
proteins
pubmed
21925322
uniprot
proteins
pubmed
22389435
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23824326
uniprot
proteins
pubmed
24681537
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
27105113
uniprot
proteins
pubmed
27105115
uniprot
proteins
pubmed
27530147
uniprot
proteins
pubmed
27723750
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
30154464
uniprot
proteins
pubmed
31542297
uniprot
proteins
pubmed
31645732
uniprot
proteins
pubmed
34545082
uniprot
proteins
pubmed
34874266
uniprot
proteins
pubmed
34961760
uniprot
proteins
pubmed
9710638
uniprot
proteins
sequence_length
126
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome.
uniprot
proteins