Pttg1
entrez
64193
canonical
uniprot
P97613
canonical
ensembl
ENSRNOG00000003802
resolver
ensembl
ENSRNOG00055018788
resolver
ensembl
ENSRNOG00060020891
resolver
ensp
ENSRNOP00000005070
resolver
ensp
ENSRNOP00000086678
resolver
ensp
ENSRNOP00055025901
resolver
ensp
ENSRNOP00060029736
resolver
enst
ENSRNOT00000005070
resolver
enst
ENSRNOT00000093944
resolver
enst
ENSRNOT00055032030
resolver
enst
ENSRNOT00060036162
resolver
genesymbol
Pttg1
resolver
genesymbol_syn
Pttg
resolver
uniprot
A0A8I6A1P6
resolver
uniprot
B0BMT1
resolver
uniprot_entry
A0A8I6A1P6_RAT
resolver
uniprot_entry
B0BMT1_RAT
resolver
uniprot_entry
PTTG1_RAT
resolver
amino_acid_sequence
MATLIFVDKDNEEPGSRLASKDGLKLGSGVKALDGKLQVSTPRVGKVFGAPGLPKASRKALGTVNRVTEKPVKSSKPLQSKQPTLSVKKITEKSTKTQGSAPAPDDAYPEIEKFFPFDPLDFESFDLPEEHQISLLPLNGVPLMILNEERGLEKLLHLDPPSPLQKPFLPWESDPLPSPPSALSALDVELPPVCYDADI
uniprot
proteins
disease_involvement
DISEASE: Note=Has strong transforming capabilities on a variety of cell lines including NIH 3T3 fibroblasts and on athymic nude mice. Overexpressed in animals suffering from pituitary adenomas. The transforming capability may be due to its interaction and regulation of p53/TP53 pathway. {ECO:0000269|PubMed:9092795}.
uniprot
proteins
function
FUNCTION: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of p53/TP53. The negative regulation of p53/TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
21571
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-162 by CDK1 during mitosis. {ECO:0000250}.; PTM: Phosphorylated in vitro by ds-DNA kinase. {ECO:0000250}.; PTM: Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties by the anaphase promoting complex (APC) at the onset of anaphase, conducting to its degradation. 'Lys-11'-linked ubiquitination is mediated by the E2 ligase UBE2C/UBCH10 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Securin family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9092795
uniprot
proteins
pubmed
9478977
uniprot
proteins
pubmed
9915854
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins