Pnliprp2
entrez
117554
canonical
uniprot
P54318
canonical
ensembl
ENSRNOG00000017982
resolver
ensp
ENSRNOP00000063609
resolver
enst
ENSRNOT00000068119
resolver
genesymbol
Pnliprp2
resolver
genesymbol_syn
Plrp2
resolver
uniprot
D3ZX17
resolver
uniprot_entry
D3ZX17_RAT
resolver
uniprot_entry
LIPR2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: CLPS stimulates triacylglycerol lipase activity. Triacylglycerol lipase activity is not inhibited by increasing bile salt concentration. {ECO:0000269|PubMed:8656075}.
uniprot
proteins
amino_acid_sequence
MLLCWIVSLLLATVGGKEVCYGHLGCFSNDKPWAGMLQRPLKIFPWSPEDIDTRFLLYTNENPNNYQKISATEPDTIKFSNFQLDRKTRFIVHGFIDKGEDGWLLDMCKKMFQVEKVNCICVDWRRGSRTEYTQASYNTRVVGAEIAFLVQVLSTEMGYSPENVHLIGHSLGAHVVGEAGRRLEGHVGRITGLDPAEPCFQGLPEEVRLDPSDAMFVDVIHTDSAPIIPYLGFGMSQKVGHLDFFPNGGKEMPGCQKNILSTIVDINGIWEGTQNFVACNHLRSYKYYASSILNPDGFLGYPCSSYEKFQQNDCFPCPEEGCPKMGHYADQFEGKTATVEQTVYLNTGDSGNFTRWRYKVSVTLSGAKKLSGYILVALYGNNGNSKQYEIFKGSLKPEARHVRDIDVDINVGEIQKVKFLWNNKVINLFRPTLGASQITVQSGVDGKEYNFCSSDTVREDVLQSLYPC
uniprot
proteins
ec_number
3.1.1.26
uniprot
proteins
ec_number
3.1.1.3
uniprot
proteins
function
FUNCTION: Lipase that primarily hydrolyzes triglycerides and galactosylglycerides (PubMed:8656075, PubMed:9822688). In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (By similarity). Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (PubMed:8656075). Can completely deacylate triacylglycerols (By similarity). When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase (By similarity). Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids (By similarity). Hydrolyzes medium- and long-chain fatty acyls in galactolipids (PubMed:9822688). May act together with LIPF to hydrolyze partially digested triglycerides (By similarity). Hydrolyzes long-chain monoglycerides with high efficiency. In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Also has low phospholipase activity (PubMed:8656075, PubMed:9822688). In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (PubMed:32963038). The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (PubMed:32963038). {ECO:0000250|UniProtKB:P17892, ECO:0000250|UniProtKB:P54317, ECO:0000269|PubMed:32963038, ECO:0000269|PubMed:8656075, ECO:0000269|PubMed:9822688}.
uniprot
proteins
mass_dalton
52535
uniprot
proteins
mutagenesis
MUTAGEN 170; /note="S->G: Abolishes rescue of lipase-deficient activity in Pnliprp2 knockout neurons."; /evidence="ECO:0000269|PubMed:32963038"; MUTAGEN 281; /note="H->L: Abolishes rescue of lipase-deficient activity in Pnliprp2 knockout neurons."; /evidence="ECO:0000269|PubMed:32963038
uniprot
proteins
pathway_participation
PATHWAY: Glycerolipid metabolism; triacylglycerol degradation. {ECO:0000250|UniProtKB:P54317}.; PATHWAY: Glycolipid metabolism. {ECO:0000250|UniProtKB:P54317}.
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
Lipase family
uniprot
proteins
pubmed
32963038
uniprot
proteins
pubmed
8203536
uniprot
proteins
pubmed
8486693
uniprot
proteins
pubmed
8656075
uniprot
proteins
pubmed
9822688
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P54317}. Zymogen granule membrane {ECO:0000269|PubMed:8486693}; Peripheral membrane protein {ECO:0000305|PubMed:8486693}. Cell projection, neuron projection {ECO:0000269|PubMed:32963038}. Note=Localizes to neurite tips in neuronal cells. {ECO:0000269|PubMed:32963038}.
uniprot
proteins