Lyset
entrez
320351
canonical
uniprot
Q8BH26
canonical
ensembl
ENSMUSG00000046675
resolver
ensp
ENSMUSP00000054611
resolver
enst
ENSMUST00000057416
resolver
genesymbol
Lyset
resolver
genesymbol_syn
C14orf109
resolver
genesymbol_syn
Tmem251
resolver
uniprot_entry
LYSET_MOUSE
resolver
amino_acid_sequence
MPKAPDCSELSDSCSLAGGTGRFSGPLHRAWRMMNFRQRMGWIGVGLYLLASAAAFYYVFEINETYNRLALEHILQHPEEPREGTTWTHSLKARLLSLPFWLWTIIFLIPYLQMFLFLYSCTRADPKTVGYCIIPICLAVICNRHQAFVKASNQISRLQLIDT
uniprot
proteins
function
FUNCTION: Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes. LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB. GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes. LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases (By similarity). Plays an essential function for cells that depend on lysosomal catabolism to generate nutrients (PubMed:36074821). {ECO:0000250|UniProtKB:Q8N6I4, ECO:0000269|PubMed:36074821}.
uniprot
proteins
mass_dalton
18720
uniprot
proteins
protein_family
LYSET family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
36074821
uniprot
proteins
pubmed
36074822
uniprot
proteins
sequence_length
163
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8N6I4}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with GNPTAB and GNPTG in Golgi apparatus cisternae. {ECO:0000250|UniProtKB:Q8N6I4}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 98..118; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins