Sdc1
entrez
20969
canonical
uniprot
P18828
canonical
ensembl
ENSMUSG00000020592
resolver
ensp
ENSMUSP00000020911
resolver
genesymbol
Sdc1
resolver
genesymbol_syn
Synd-1
resolver
genesymbol_syn
Synd1
resolver
uniprot
Q3V1F2
resolver
uniprot
Q62278
resolver
uniprot
Q9WVD2
resolver
uniprot_entry
Q3V1F2_MOUSE
resolver
uniprot_entry
SDC1_MOUSE
resolver
uniprot_sec
Q62278
resolver
uniprot_sec
Q9WVD2
resolver
amino_acid_sequence
MRRAALWLWLCALALRLQPALPQIVAVNVPPEDQDGSGDDSDNFSGSGTGALPDTLSRQTPSTWKDVWLLTATPTAPEPTSSNTETAFTSVLPAGEKPEEGEPVLHVEAEPGFTARDKEKEVTTRPRETVQLPITQRASTVRVTTAQAAVTSHPHGGMQPGLHETSAPTAPGQPDHQPPRVEGGGTSVIKEVVEDGTANQLPAGEGSGEQDFTFETSGENTAVAAVEPGLRNQPPVDEGATGASQSLLDRKEVLGGVIAGGLVGLIFAVCLVAFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA
uniprot
proteins
function
FUNCTION: Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (PubMed:8163535). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (By similarity). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (PubMed:8898217). {ECO:0000250|UniProtKB:P18827, ECO:0000269|PubMed:8163535, ECO:0000269|PubMed:8898217}.
uniprot
proteins
mass_dalton
32905
uniprot
proteins
post_translational_modification
PTM: Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. {ECO:0000269|PubMed:10684261}.
uniprot
proteins
protein_family
Syndecan proteoglycan family
uniprot
proteins
pubmed
10373479
uniprot
proteins
pubmed
10684261
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16156648
uniprot
proteins
pubmed
20361982
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2494194
uniprot
proteins
pubmed
8163535
uniprot
proteins
pubmed
8349612
uniprot
proteins
pubmed
8496192
uniprot
proteins
pubmed
8898217
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:10684261}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P18827}. Note=Shedding of the ectodomain produces a soluble form. {ECO:0000269|PubMed:10684261}.
uniprot
proteins
transmembrane_region
TRANSMEM 256..276; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins