Slc17a9
entrez
362287
canonical
uniprot
P0DX21
canonical
ensembl
ENSRNOG00000010275
resolver
ensembl
ENSRNOG00055001105
resolver
ensembl
ENSRNOG00060001442
resolver
ensembl
ENSRNOG00065014571
resolver
ensp
ENSRNOP00000013621
resolver
ensp
ENSRNOP00000104893
resolver
ensp
ENSRNOP00055001423
resolver
ensp
ENSRNOP00060001316
resolver
ensp
ENSRNOP00065018776
resolver
enst
ENSRNOT00000013623
resolver
enst
ENSRNOT00000166635
resolver
enst
ENSRNOT00055001823
resolver
enst
ENSRNOT00060002121
resolver
enst
ENSRNOT00065024074
resolver
genesymbol
Slc17a9
resolver
uniprot
A0ABK0LH66
resolver
uniprot
D3ZUN1
resolver
uniprot_entry
A0ABK0LH66_RAT
resolver
uniprot_entry
D3ZUN1_RAT
resolver
uniprot_entry
S17A9_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activity is chloride-dependent. {ECO:0000250|UniProtKB:Q9BYT1}.
uniprot
proteins
amino_acid_sequence
MPSQRSSLMQPIPEETRKTPSAAAEDKRWSRPECQLWTGMLLLGTCLLYCTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLLAHLGSGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLLWVYYVYKYLLDEKDLVLALGVLAQGLPVTRPSKVPWRQLFRKASVWAVICSQLSSACSFFILLSWLPTFFKETFPHSKGWVFNVVPWLLAIPASLFSGFISDRLISQGYRVITVRKFMQVMGLGLSSIFALCLGHTTSFLKSMIFASASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLIETTGSWTCVFHLVAIVSNLGLGTFLVFGKAQRVDLVPTHEDL
uniprot
proteins
function
FUNCTION: Voltage-gated ATP nucleotide uniporter that can also transport the purine nucleotides ADP and GTP. Uses the membrane potential as the driving force to control ATP accumulation in lysosomes and secretory vesicles (PubMed:18375752). By controlling ATP storage in lysosomes, regulates ATP-dependent proteins of these organelles (By similarity). Also indirectly regulates the exocytosis of ATP through its import into lysosomes in astrocytes and secretory vesicles such as adrenal chromaffin granules, mucin granules and synaptic vesicles (PubMed:18375752). {ECO:0000250|UniProtKB:Q8VCL5, ECO:0000269|PubMed:18375752}.
uniprot
proteins
mass_dalton
48638
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sodium/anion cotransporter family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
18375752
uniprot
proteins
pubmed
23832620
uniprot
proteins
sequence_length
447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:Q8VCL5}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q8VCL5}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q8VCL5}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to mucin granules and vesicles (By similarity). Localization to lysosomes was not confirmed in microglial cells (PubMed:23832620). {ECO:0000250|UniProtKB:Q9BYT1, ECO:0000269|PubMed:23832620}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..58; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 74..94; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 129..149; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 197..217; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 252..272; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 287..307; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 327..347; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 380..400; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 413..433; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins