ARL6IP5
entrez
10550
canonical
uniprot
O75915
canonical
ensembl
ENSG00000144746
resolver
ensp
ENSP00000273258
resolver
enst
ENST00000273258
resolver
genesymbol
ARL6IP5
resolver
genesymbol_syn
DERP11
resolver
genesymbol_syn
JWA
resolver
genesymbol_syn
PRA2
resolver
genesymbol_syn
PRAF3
resolver
hgnc
HGNC:16937
resolver
uniprot
B2R6V5
resolver
uniprot
Q53ES3
resolver
uniprot
Q5KU08
resolver
uniprot_entry
PRAF3_HUMAN
resolver
uniprot_sec
B2R6V5
resolver
uniprot_sec
Q53ES3
resolver
uniprot_sec
Q5KU08
resolver
amino_acid_sequence
MDVNIAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISIVGFLSPFNMILGGIVVVLVFTGFVWAAHNKDVLRRMKKRYPTTFVMVVMLASYFLISMFGGVMVFVFGITFPLLLMFIHASLRLRNLKNKLENKMEGIGLKRTPMGIVLDALEQQEEGINRLTDYISKVKE
uniprot
proteins
function
FUNCTION: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q8R5J9, ECO:0000250|UniProtKB:Q9ES40}.
uniprot
proteins
mass_dalton
21615
uniprot
proteins
protein_family
PRA1 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
12438930
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12761501
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14761432
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15757671
uniprot
proteins
pubmed
16481131
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
188
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ES40}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9ES40}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9ES40}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9ES40}. Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules. {ECO:0000250|UniProtKB:Q9ES40}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 57..77; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins