Alad
entrez
17025
canonical
uniprot
P10518
canonical
ensembl
ENSMUSG00000028393
resolver
ensp
ENSMUSP00000030090
resolver
ensp
ENSMUSP00000103068
resolver
ensp
ENSMUSP00000272174
resolver
enst
ENSMUST00000030090
resolver
enst
ENSMUST00000107444
resolver
genesymbol
Alad
resolver
genesymbol_syn
Lv
resolver
uniprot
Q3THV6
resolver
uniprot
Q9DD05
resolver
uniprot_entry
HEM2_MOUSE
resolver
uniprot_entry
Q9DD05_MOUSE
resolver
uniprot_sec
Q3THV6
resolver
activity_regulation
ACTIVITY REGULATION: Can alternate between a fully active homooctamer and a low-activity homohexamer. A bound magnesium ion may promote the assembly of the fully active homooctamer. The magnesium-binding site is absent in the low-activity homohexamer. Inhibited by compounds that favor the hexameric state. Inhibited by divalent lead ions. The lead ions partially displace the zinc cofactor. {ECO:0000250|UniProtKB:P13716}.
uniprot
proteins
amino_acid_sequence
MHHQSVLHSGYFHPLLRSWQTAASTVSASNLIYPIFVTDVPDDVQPIASLPGVARYGVNQLEEMLRPLVEAGLRCVLIFGVPSRVPKDEQGSAADSEDSPTIEAVRLLRKTFPSLLVACDVCLCPYTSHGHCGLLSENGAFLAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKAALLKHGLGNRVSVMSYSAKFASCFYGPFRDAAQSSPAFGDRRCYQLPPGARGLALRAVARDIQEGADMLMVKPGLPYLDMVREVKDKHPELPLAVYQVSGEFAMLWHGAQAGAFDLRTAVLETMTAFRRAGADIIITYFAPQLLKWLKEE
uniprot
proteins
ec_number
4.2.1.24
uniprot
proteins
function
FUNCTION: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. {ECO:0000269|PubMed:4981581}.
uniprot
proteins
mass_dalton
36024
uniprot
proteins
pathway_participation
PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4. {ECO:0000250|UniProtKB:P13716}.
uniprot
proteins
protein_family
ALAD family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
2922298
uniprot
proteins
pubmed
4981581
uniprot
proteins
sequence_length
330
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:4981581}.
uniprot
proteins