IAPP
entrez
3375
canonical
uniprot
P10997
canonical
ensembl
ENSG00000121351
resolver
ensp
ENSP00000240652
resolver
ensp
ENSP00000437357
resolver
ensp
ENSP00000548040
resolver
enst
ENST00000240652
resolver
enst
ENST00000539393
resolver
enst
ENST00000877981
resolver
genesymbol
IAPP
resolver
hgnc
HGNC:5329
resolver
uniprot
Q0ZD87
resolver
uniprot
Q14598
resolver
uniprot_entry
IAPP_HUMAN
resolver
uniprot_sec
Q0ZD87
resolver
uniprot_sec
Q14598
resolver
amino_acid_sequence
MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKRNAVEVLKREPLNYLPL
uniprot
proteins
function
FUNCTION: Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (PubMed:2690069). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes (By similarity). Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (By similarity). {ECO:0000250|UniProtKB:P12969, ECO:0000269|PubMed:2690069}.
uniprot
proteins
mass_dalton
9806
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="F->A,D,S: Promotes formation of fibrillar aggregates."; /evidence="ECO:0000269|PubMed:19475663
uniprot
proteins
post_translational_modification
PTM: Amyloid fibrils are degraded by insulin-degrading enzyme IDE. {ECO:0000269|PubMed:17051221}.
uniprot
proteins
protein_family
Calcitonin family
uniprot
proteins
pubmed
12717720
uniprot
proteins
pubmed
1282806
uniprot
proteins
pubmed
17051221
uniprot
proteins
pubmed
17374526
uniprot
proteins
pubmed
19244249
uniprot
proteins
pubmed
19475663
uniprot
proteins
pubmed
2039456
uniprot
proteins
pubmed
2091067
uniprot
proteins
pubmed
2223885
uniprot
proteins
pubmed
2365085
uniprot
proteins
pubmed
2608057
uniprot
proteins
pubmed
2651160
uniprot
proteins
pubmed
2666169
uniprot
proteins
pubmed
2690069
uniprot
proteins
pubmed
3035556
uniprot
proteins
pubmed
3053705
uniprot
proteins
pubmed
3181427
uniprot
proteins
pubmed
3317417
uniprot
proteins
pubmed
3535798
uniprot
proteins
pubmed
8772735
uniprot
proteins
pubmed
9794116
uniprot
proteins
sequence_length
89
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17374526}.
uniprot
proteins