SAPCD2
entrez
89958
canonical
uniprot
Q86UD0
canonical
ensembl
ENSG00000186193
resolver
ensp
ENSP00000386348
resolver
ensp
ENSP00000549093
resolver
enst
ENST00000409687
resolver
genesymbol
SAPCD2
resolver
genesymbol_syn
C9orf140
resolver
hgnc
HGNC:28055
resolver
uniprot_entry
SAPC2_HUMAN
resolver
amino_acid_sequence
MAGAAMAERGRVPPPAPAPSTEGLPRAFLQSLRTLFDILDDRRRGCVHLREIESRWQGTDARELPRGVLEGLRQVAPASGYLTFERFVAGLRTSLLSADGGPRDPTRAPARPGDQPPPPPQRLVFAPADEPRTVLERKPLPLGVRAPLAGPSAAARSPEQLCAPAEAAPCPAEPERSQSAALEPSSSADAGAVACRALEADSGDARRAPRARGERRRHTIASGVDCGLLKQMKELEQEKEVLLQGLEMMARGRDWYQQQLQRVQERQRRLGQSRASADFGAAGSPRPLGRLLPKVQEVARCLGELLAAACASRALPPSSSGPPCPALTSTSPPVWQQQTILMLKEQNRLLTQEVTEKSERITQLEQEKSALIKQLFEARALSQQDGGPLDSTFI
uniprot
proteins
function
FUNCTION: Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824). {ECO:0000250|UniProtKB:Q9D818, ECO:0000269|PubMed:23576022, ECO:0000269|PubMed:23704824, ECO:0000269|PubMed:26766442}.
uniprot
proteins
mass_dalton
42637
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17525738
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23576022
uniprot
proteins
pubmed
23704824
uniprot
proteins
pubmed
26766442
uniprot
proteins
sequence_length
394
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17525738}. Nucleus {ECO:0000269|PubMed:17525738}. Cytoplasm, cell cortex {ECO:0000269|PubMed:26766442}. Apical cell membrane {ECO:0000250|UniProtKB:Q9D818}. Cell junction, tight junction {ECO:0000269|PubMed:26766442}. Note=Localized at the apical cortical region during the M phase. In horizontally retinal progenitor dividing cells, localized at the pole cortical region from prophase to telophase cells. In vertically retinal progenitor dividing cells, not detected at the pole cortical region at any stage of mitosis. {ECO:0000250|UniProtKB:Q9D818}.
uniprot
proteins