TGFBRAP1
entrez
9392
canonical
uniprot
Q8WUH2
canonical
ensembl
ENSG00000135966
resolver
ensp
ENSP00000377027
resolver
ensp
ENSP00000471434
resolver
ensp
ENSP00000550331
resolver
ensp
ENSP00000550332
resolver
ensp
ENSP00000581339
resolver
ensp
ENSP00000639328
resolver
ensp
ENSP00000755383
resolver
enst
ENST00000393359
resolver
enst
ENST00000595531
resolver
enst
ENST00000880272
resolver
enst
ENST00000880273
resolver
enst
ENST00000911280
resolver
enst
ENST00000969269
resolver
genesymbol
TGFBRAP1
resolver
hgnc
HGNC:16836
resolver
uniprot
A8K5R7
resolver
uniprot
D3DVJ8
resolver
uniprot
O60466
resolver
uniprot_entry
TGFA1_HUMAN
resolver
uniprot_sec
A8K5R7
resolver
uniprot_sec
D3DVJ8
resolver
uniprot_sec
O60466
resolver
amino_acid_sequence
MMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTNDCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPVNELRAASALNRLLVLCDNSISLVNMLNLEPVPSGARIKGAATFALNENPVSGDPFCVEVCIISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFLCLALTTQYIIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATVAGISQRAPVHWSENVIGAAVSFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLPLEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQVMYRRILQQAGFIQFAQLQFLEAKELFRSGQLDVRELISLYPFLLPTSSSFTRSHPPLHEYADLNQLTQGDQEKMAKCKRFLMSYLNEVRSTEVANGYKEDIDTALLKLYAEADHDSLLDLLVTENFCLLTDSAAWLEKHKKYFALGLLYHYNNQDAAAVQLWVNIVNGDVQDSTRSDLYEYIVDFLTYCLDEELVWAYADWVLQKSEEVGVQVFTKRPLDEQQKNSFNPDDIINCLKKYPKALVKYLEHLVIDKRLQKEEYHTHLAVLYLEEVLLQRASASGKGAEATETQAKLRRLLQKSDLYRVHFLLERLQGAGLPMESAILHGKLGEHEKALHILVHELQDFAAAEDYCLWCSEGRDPPHRQQLFHTLLAIYLHAGPTAHELAVAAVDLLNRHATEFDAAQVLQMLPDTWSVQLLCPFLMGAMRDSIHARRTMQVALGLARSENLIYTYDKMKLKGSSIQLSDKKLCQICQNPFCEPVFVRYPNGGLVHTHCAASRHTNPSSSSPGTRT
uniprot
proteins
function
FUNCTION: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. {ECO:0000269|PubMed:11278302, ECO:0000269|PubMed:9545258}.; FUNCTION: Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo (PubMed:25266290). {ECO:0000269|PubMed:25266290, ECO:0000305|PubMed:25266290}.
uniprot
proteins
mass_dalton
97158
uniprot
proteins
protein_family
TRAP1 family
uniprot
proteins
pubmed
10051563
uniprot
proteins
pubmed
11278302
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
25266290
uniprot
proteins
pubmed
9545258
uniprot
proteins
sequence_length
860
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11278302}. Early endosome {ECO:0000269|PubMed:25266290}. Note=Colocalizes with TGF-beta receptors in the absence of signaling.
uniprot
proteins