Map2k2
entrez
26396
canonical
uniprot
Q63932
canonical
ensembl
ENSMUSG00000035027
resolver
ensp
ENSMUSP00000100968
resolver
ensp
ENSMUSP00000121111
resolver
enst
ENSMUST00000105331
resolver
enst
ENSMUST00000143517
resolver
genesymbol
Map2k2
resolver
genesymbol_syn
Mek2
resolver
genesymbol_syn
Mkk2
resolver
genesymbol_syn
Prkmk2
resolver
uniprot
F6TW03
resolver
uniprot
Q8CB46
resolver
uniprot
Q91YS7
resolver
uniprot
Q9D7B0
resolver
uniprot_entry
F6TW03_MOUSE
resolver
uniprot_entry
MP2K2_MOUSE
resolver
uniprot_entry
Q8CB46_MOUSE
resolver
uniprot_entry
Q91YS7_MOUSE
resolver
uniprot_sec
Q9D7B0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by serine/threonine phosphatase 2A.
uniprot
proteins
amino_acid_sequence
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELDLDEQQRKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLMNHAFIKRSEGEEVDFAGWLCRTLRLKQPSTPTRTAV
uniprot
proteins
ec_number
2.7.12.2
uniprot
proteins
function
FUNCTION: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (PubMed:19219045). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). {ECO:0000250|UniProtKB:P36507, ECO:0000269|PubMed:19219045}.
uniprot
proteins
mass_dalton
44402
uniprot
proteins
mutagenesis
MUTAGEN 101; /note="K->M: Inactivation."; /evidence="ECO:0000269|PubMed:8297798
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser/Thr by MAP kinase kinase kinases (RAF or MEKK1) positively regulates the kinase activity. Phosphorylated by MAP2K1/MEK1. Low levels of autophosphorylation have been observed. {ECO:0000269|PubMed:19219045}.
uniprot
proteins
protein_family
MAP kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
10409742
uniprot
proteins
pubmed
1381507
uniprot
proteins
pubmed
15118098
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19219045
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8297798
uniprot
proteins
sequence_length
401
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10409742}. Membrane {ECO:0000269|PubMed:10409742}; Peripheral membrane protein {ECO:0000269|PubMed:10409742}. Note=Membrane localization is probably regulated by its interaction with KSR1. {ECO:0000269|PubMed:10409742}.
uniprot
proteins