Stk38
entrez
106504
canonical
uniprot
Q91VJ4
canonical
ensembl
ENSMUSG00000024006
resolver
ensp
ENSMUSP00000009138
resolver
ensp
ENSMUSP00000113657
resolver
ensp
ENSMUSP00000156592
resolver
ensp
ENSMUSP00000156711
resolver
enst
ENSMUST00000009138
resolver
enst
ENSMUST00000119274
resolver
enst
ENSMUST00000232836
resolver
genesymbol
Stk38
resolver
genesymbol_syn
Ndr1
resolver
uniprot_entry
STK38_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38. {ECO:0000250|UniProtKB:Q15208}.
uniprot
proteins
amino_acid_sequence
MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPVSEKAKGLILRFCCEWEHRIGAPGVEEIKNNLFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVTTSSHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKAAK
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:21730291). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (By similarity). {ECO:0000250|UniProtKB:Q15208, ECO:0000269|PubMed:21730291}.
uniprot
proteins
mass_dalton
54174
uniprot
proteins
post_translational_modification
PTM: ISGylated. {ECO:0000250|UniProtKB:Q15208}.; PTM: Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B. {ECO:0000250|UniProtKB:Q15208}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15037617
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21730291
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15208}. Cytoplasm {ECO:0000250|UniProtKB:Q15208}. Chromosome {ECO:0000250|UniProtKB:Q15208}. Note=Localizes to DNA double-strand breaks in response to DNA damage. {ECO:0000250|UniProtKB:Q15208}.
uniprot
proteins