Snap25
entrez
25012
canonical
uniprot
P60881
canonical
ensembl
ENSRNOG00000006037
resolver
ensembl
ENSRNOG00055023176
resolver
ensembl
ENSRNOG00060002425
resolver
ensembl
ENSRNOG00065028823
resolver
ensp
ENSRNOP00000007998
resolver
ensp
ENSRNOP00000008734
resolver
ensp
ENSRNOP00000072612
resolver
genesymbol
Snap25
resolver
genesymbol_syn
Snap
resolver
uniprot
P13795
resolver
uniprot
P36974
resolver
uniprot
P70557
resolver
uniprot
P70558
resolver
uniprot
Q8IXK3
resolver
uniprot
Q96FM2
resolver
uniprot
Q9BR45
resolver
uniprot_entry
SNP25_RAT
resolver
uniprot_sec
P13795
resolver
uniprot_sec
P36974
resolver
uniprot_sec
P70557
resolver
uniprot_sec
P70558
resolver
uniprot_sec
Q8IXK3
resolver
uniprot_sec
Q96FM2
resolver
uniprot_sec
Q9BR45
resolver
amino_acid_sequence
MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNLTDLGKFCGLCVCPCNKLKSSDAYKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG
uniprot
proteins
function
FUNCTION: t-SNARE involved in the molecular regulation of neurotransmitter release (PubMed:8103915, PubMed:8243676). May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells (PubMed:12403834). {ECO:0000269|PubMed:12403834, ECO:0000305|PubMed:8103915, ECO:0000305|PubMed:8243676}.
uniprot
proteins
mass_dalton
23315
uniprot
proteins
mutagenesis
MUTAGEN 113; /note="V->A: Inhibits interaction with ZDHHC13 and ZDHHC17."; /evidence="ECO:0000269|PubMed:26198635"; MUTAGEN 116; /note="Q->A: Inhibits interaction with ZDHHC13 and ZDHHC17."; /evidence="ECO:0000269|PubMed:26198635"; MUTAGEN 117; /note="P->A: Inhibits interaction with ZDHHC13 and ZDHHC17."; /evidence="ECO:0000269|PubMed:26198635
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association (By similarity). {ECO:0000250|UniProtKB:P60879}.; PTM: (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type A (BoNT/A, botA) which hydrolyzes the 197-Gln-|-Arg-198 bond and inhibits neurotransmitter release (PubMed:8103915, PubMed:8243676). {ECO:0000269|PubMed:8243676, ECO:0000269|PubMed:8294407, ECO:0000305|PubMed:8103915}.; PTM: (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type E (BoNT/E) which hydrolyzes the 180-Arg-|-Ile-181 bond and inhibits neurotransmitter release (PubMed:8103915, PubMed:8243676). {ECO:0000269|PubMed:8243676, ECO:0000269|PubMed:8294407, ECO:0000305|PubMed:8103915}.
uniprot
proteins
protein_family
SNAP-25 family
uniprot
proteins
pubmed
10037470
uniprot
proteins
pubmed
10336434
uniprot
proteins
pubmed
11438518
uniprot
proteins
pubmed
11533035
uniprot
proteins
pubmed
12145319
uniprot
proteins
pubmed
12403834
uniprot
proteins
pubmed
12459461
uniprot
proteins
pubmed
12496247
uniprot
proteins
pubmed
1281490
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19196426
uniprot
proteins
pubmed
23341457
uniprot
proteins
pubmed
26198635
uniprot
proteins
pubmed
8103915
uniprot
proteins
pubmed
8243676
uniprot
proteins
pubmed
8294407
uniprot
proteins
pubmed
8738135
uniprot
proteins
pubmed
9039916
uniprot
proteins
pubmed
9759724
uniprot
proteins
sequence_length
206
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P60879}. Cell membrane {ECO:0000269|PubMed:12403834, ECO:0000269|PubMed:23341457}; Lipid-anchor {ECO:0000250|UniProtKB:P60879}. Synapse, synaptosome {ECO:0000269|PubMed:1281490}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P60879}. Note=Membrane association requires palmitoylation (By similarity). Expressed throughout cytoplasm, concentrating at the perinuclear region (By similarity). Colocalizes with KCNB1 at the cell membrane (PubMed:12403834). Colocalizes with PLCL1 at the cell membrane (PubMed:23341457). {ECO:0000250|UniProtKB:P60879, ECO:0000269|PubMed:12403834, ECO:0000269|PubMed:1281490, ECO:0000269|PubMed:23341457}.
uniprot
proteins