Nhlh2
entrez
18072
canonical
uniprot
Q64221
canonical
ensembl
ENSMUSG00000048540
resolver
ensp
ENSMUSP00000064355
resolver
ensp
ENSMUSP00000142746
resolver
ensp
ENSMUSP00000143362
resolver
enst
ENSMUST00000066187
resolver
enst
ENSMUST00000196324
resolver
enst
ENSMUST00000198675
resolver
genesymbol
Nhlh2
resolver
genesymbol_syn
Hen2
resolver
uniprot
Q8BFV7
resolver
uniprot_entry
HEN2_MOUSE
resolver
uniprot_sec
Q8BFV7
resolver
amino_acid_sequence
MMLSPDQAADSDHPSSTHSDPESLGGADTKVLGSVSDLEPVEEADGDGKGGSRAALYPHPQQLSREEKRRRRRATAKYRSAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLDV
uniprot
proteins
function
FUNCTION: Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3' (PubMed:15470499, PubMed:18356286). Involved in regulating energy expenditure, body mass, voluntary physical activity, mating behavior and reproductive longevity, acting through the hypothalamic-pituitary-gonadal axis (PubMed:12419415, PubMed:15465527, PubMed:15470499, PubMed:17717072, PubMed:23785158, PubMed:9090387). Acts as a transcriptional activator of target genes, including Ndn, Pcsk1, Mc4r (PubMed:15470499, PubMed:18356286, PubMed:21664420). Is also a transcriptional activator of KISS1 (By similarity). May act centrally to regulate function of both white and brown adipose tissue (PubMed:19436734, PubMed:20808804). Together with NHLH1, required to maintain migration and survival of cells in the anterior extramural migration stream (aes), which forms the precerebellar nuclei (PubMed:17573818). Also, in concert with Nhlh1, may determine fate of gonadotropin releasing hormone-1 (GnRH-1) neurons (PubMed:15470499). {ECO:0000250|UniProtKB:Q02577, ECO:0000269|PubMed:12419415, ECO:0000269|PubMed:15465527, ECO:0000269|PubMed:15470499, ECO:0000269|PubMed:17573818, ECO:0000269|PubMed:17717072, ECO:0000269|PubMed:18356286, ECO:0000269|PubMed:19436734, ECO:0000269|PubMed:20808804, ECO:0000269|PubMed:21664420, ECO:0000269|PubMed:23785158, ECO:0000269|PubMed:9090387}.
uniprot
proteins
mass_dalton
15004
uniprot
proteins
pubmed
12419415
uniprot
proteins
pubmed
15465527
uniprot
proteins
pubmed
15470499
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1633105
uniprot
proteins
pubmed
17573818
uniprot
proteins
pubmed
17717072
uniprot
proteins
pubmed
18356286
uniprot
proteins
pubmed
19436734
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20808804
uniprot
proteins
pubmed
21664420
uniprot
proteins
pubmed
23785158
uniprot
proteins
pubmed
9011755
uniprot
proteins
pubmed
9090387
uniprot
proteins
sequence_length
135
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
uniprot
proteins