Samd1
entrez
666704
canonical
uniprot
D3YXK1
canonical
ensembl
ENSMUSG00000079003
resolver
ensp
ENSMUSP00000092853
resolver
enst
ENSMUST00000095228
resolver
genesymbol
Samd1
resolver
uniprot_entry
SAMD1_MOUSE
resolver
amino_acid_sequence
MAGPPALPPPETAAAATTAAAASSSAASPHYQEWILDTIDSLRSRKARPDLERICRMVRRRHGPEPERTRAELEKLIQQRAVLRVSYKGSISYRNAARVQPPRRGATPPAPPRVPRGGPAAPPPTPAPPPAPVAAPTRAPRAAAATAPPSPGPAQPGPRAQRAAPLAAPPPAPAAPPAAAPPAGPRRAPPPAVAAREPPAPPQQQQPPPPQPQPPPEGGAARAGGPARPVSLREVVRYLGGSGGASGRLTRGRVQGLLEEEAARGRLERTRLGALALPRGDRPGRAPPAASARAARSKRGGEERVFEKEEEDEDEDEEEEEEDNVSEGSEVPESDRPAGAQHHQINGERGPQSAKERVKEWSPCGPYQGQDEGRGPAPGSCTRQVFPMTAVNKEGGSACVGAAPDSPSPVPLPPGKPALPGADGTPFGCPPGRKEKPTDPVEWTVMDVVEYFTEAGFPEQATAFQEQEIDGKSLLLMQRTDVLTGLSIRLGPALKIYEHHIKVLQQGHFEDDDPDGLLG
uniprot
proteins
function
FUNCTION: Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor (PubMed:33980486, PubMed:34006929). Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs (PubMed:33980486). Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell (PubMed:34006929). {ECO:0000269|PubMed:33980486, ECO:0000269|PubMed:34006929}.
uniprot
proteins
mass_dalton
54533
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33980486
uniprot
proteins
pubmed
34006929
uniprot
proteins
sequence_length
519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33980486}. Chromosome {ECO:0000269|PubMed:33980486}. Secreted {ECO:0000269|PubMed:34006929}. Note=In atherosclerotic lesions, it is found in the extracellular compartment and in foam cells cytoplasm. {ECO:0000269|PubMed:34006929}.
uniprot
proteins