SNX5
entrez
27131
canonical
uniprot
Q9Y5X3
canonical
ensembl
ENSG00000089006
resolver
ensp
ENSP00000366988
resolver
ensp
ENSP00000366998
resolver
genesymbol
SNX5
resolver
hgnc
HGNC:14969
resolver
uniprot
B7ZKN3
resolver
uniprot
D3DW26
resolver
uniprot
Q52LC4
resolver
uniprot
Q6P5V6
resolver
uniprot
Q7KZN0
resolver
uniprot
Q9BWP0
resolver
uniprot_entry
Q6P5V6_HUMAN
resolver
uniprot_entry
SNX5_HUMAN
resolver
uniprot_sec
B7ZKN3
resolver
uniprot_sec
D3DW26
resolver
uniprot_sec
Q52LC4
resolver
uniprot_sec
Q7KZN0
resolver
uniprot_sec
Q9BWP0
resolver
amino_acid_sequence
MAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFTGVKEVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN
uniprot
proteins
function
FUNCTION: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941). {ECO:0000269|PubMed:18854019, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:15561769, ECO:0000303|PubMed:19619496, ECO:0000303|PubMed:23085988}.
uniprot
proteins
mass_dalton
46816
uniprot
proteins
mutagenesis
MUTAGEN 186..187; /note="FF->EE: No effect on dimerization."; /evidence="ECO:0000269|PubMed:23085988"; MUTAGEN 224; /note="K->E: Decreaes phosphoinositide binding, including PtdIns(3,4)P2 and PtdIns(3P); when associated with E-235, E-324, E-328 and E-330."; /evidence="ECO:0000269|PubMed:23602387"; MUTAGEN 235; /note="R->E: Decreaes phosphoinositide binding, including PtdIns(3,4)P2 and PtdIns(3P); when associated with E-224, E-324, E-328 and E-330."; /evidence="ECO:0000269|PubMed:23602387"; MUTAGEN 280; /note="E->A: Enables homodimerization; when associated with A-383."; /evidence="ECO:0000269|PubMed:23085988"; MUTAGEN 324; /note="K->E: Decreaes phosphoinositide binding, including PtdIns(3,4)P2 and PtdIns(3P); when associated with E-224, E-235, E-328 and E-330."; /evidence="ECO:0000269|PubMed:23602387"; MUTAGEN 328; /note="K->E: Decreaes phosphoinositide binding, including PtdIns(3,4)P2 and PtdIns(3P); when associated with E-224, E-235, E-324 and E-330."; /evidence="ECO:0000269|PubMed:23602387"; MUTAGEN 330; /note="R->E: Decreaes phosphoinositide binding, including PtdIns(3,4)P2 and PtdIns(3P); when associated with E-224, E-235, E-324 and E-328."; /evidence="ECO:0000269|PubMed:23602387"; MUTAGEN 383; /note="E->A: Enables homodimerization; when associated with A-280.
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
11485546
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15226359
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15561769
uniprot
proteins
pubmed
16857196
uniprot
proteins
pubmed
16968745
uniprot
proteins
pubmed
17148574
uniprot
proteins
pubmed
18596235
uniprot
proteins
pubmed
18854019
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19619496
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21048941
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23085988
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23602387
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24610942
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29444945
uniprot
proteins
pubmed
39073202
uniprot
proteins
sequence_length
404
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome {ECO:0000269|PubMed:11485546}. Early endosome {ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:24610942}. Early endosome membrane {ECO:0000269|PubMed:15561769}; Peripheral membrane protein; Cytoplasmic side. Cell membrane {ECO:0000269|PubMed:15561769}; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:18854019}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Note=Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2) (PubMed:15561769). Detected on macropinosomes (PubMed:16968745, PubMed:21048941). Targeted to membrane ruffles in response to EGFR stimulation. {ECO:0000269|PubMed:15561769, ECO:0000269|PubMed:16968745, ECO:0000269|PubMed:21048941}.
uniprot
proteins