SH3RF3
entrez
344558
canonical
uniprot
Q8TEJ3
canonical
ensembl
ENSG00000172985
resolver
ensp
ENSP00000309186
resolver
ensp
ENSP00000781421
resolver
enst
ENST00000309415
resolver
genesymbol
SH3RF3
resolver
genesymbol_syn
POSH2
resolver
genesymbol_syn
SH3MD4
resolver
hgnc
HGNC:24699
resolver
uniprot
A0SDZ7
resolver
uniprot
A8MPR1
resolver
uniprot
Q8NDU1
resolver
uniprot_entry
SH3R3_HUMAN
resolver
uniprot_sec
A0SDZ7
resolver
uniprot_sec
A8MPR1
resolver
uniprot_sec
Q8NDU1
resolver
amino_acid_sequence
MLLGASWLCASKAAAAAAQSEGDEDRPGERRRRRAAATAAGAGEDMDESSLLDLLECSVCLERLDTTAKVLPCQHTFCRRCLESIVCSRHELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRAGSCPIESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Has E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:20696164}.
uniprot
proteins
mass_dalton
92776
uniprot
proteins
mutagenesis
MUTAGEN 73; /note="C->A: Significant reduction in autoubiquitination; when associated with A-75."; /evidence="ECO:0000269|PubMed:20696164"; MUTAGEN 75; /note="H->A: Significant reduction in autoubiquitination; when associated with A-73."; /evidence="ECO:0000269|PubMed:20696164"; MUTAGEN 403; /note="I->N: Significant loss of interaction with RAC1; alone or when associated with P-404 and A-406."; /evidence="ECO:0000269|PubMed:20696164"; MUTAGEN 404; /note="S->P: Reduced JNK activation. Significant loss of interaction with RAC1; alone or when associated with N-403 and A-406."; /evidence="ECO:0000269|PubMed:20696164"; MUTAGEN 406; /note="P->A: Significant loss of interaction with RAC1; when associated with N-403 and P-404."; /evidence="ECO:0000269|PubMed:20696164
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000269|PubMed:20696164}.
uniprot
proteins
protein_family
SH3RF family
uniprot
proteins
pubmed
12693554
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16374509
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20696164
uniprot
proteins
sequence_length
882
uniprot
proteins