Afg1l
entrez
502479
canonical
uniprot
Q32PX9
canonical
ensembl
ENSRNOG00000043033
resolver
ensp
ENSRNOP00000082827
resolver
genesymbol
Afg1l
resolver
genesymbol_syn
Lace1
resolver
uniprot_entry
AFG1L_RAT
resolver
amino_acid_sequence
MAASWSPLVTLRSAARSRLTGRGVGCGARVIAIFPPAPGPRKPLWKAYTVQTLEGVRPTAASEAHSRALAVCHGPLAHYDFLIKAQELKNDEHQRRVVQCLQKLQEDLKGYNIEEGGLFSKLFSRNKPPKGLYVYGDVGTGKTMVMDMFYEYVEVKSKRRVHFHGFMLDVHKRIHRLKQSLPKRKVGFMAKSYDPIAPIAEEISQEASLLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSNRPPEDLYKNGLQRANFVPFIAVLKEYCNTVQLDSGVDYRKRELTPAGKLYYLTSEADVGTVMDKLFDELAQKQNDLTSPRILKVQGRELRLNKACGTVADCTFEELCERPLGASDYLELSKNFDTVIIRNIPQFSLAKRTQVRRFITLIDNFYDFKVRIICSASVPISSLFVYQHQDSESDQSRVLMDDLGLSQDSAGLSMFTGEEEIFSFQRTLSRLTEMQTEQYWIEGDRSRK
uniprot
proteins
ec_number
3.6.-.-
uniprot
proteins
function
FUNCTION: Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress. {ECO:0000250|UniProtKB:Q8WV93}.
uniprot
proteins
mass_dalton
54503
uniprot
proteins
protein_family
AFG1 ATPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250|UniProtKB:Q8WV93}.
uniprot
proteins