CETN2
entrez
1069
canonical
uniprot
P41208
canonical
ensembl
ENSG00000147400
resolver
ensembl
ENSG00000292191
resolver
ensp
ENSP00000359300
resolver
ensp
ENSP00000517979
resolver
enst
ENST00000370277
resolver
enst
ENST00000709996
resolver
genesymbol
CETN2
resolver
genesymbol_syn
CALT
resolver
genesymbol_syn
CEN2
resolver
hgnc
HGNC:1867
resolver
uniprot
B2R4T4
resolver
uniprot
Q53XW1
resolver
uniprot_entry
CETN2_HUMAN
resolver
uniprot_sec
B2R4T4
resolver
uniprot_sec
Q53XW1
resolver
amino_acid_sequence
MASNFKKANMASSSQRKRMSPKPELTEEQKQEIREAFDLFDADGTGTIDVKELKVAMRALGFEPKKEEIKKMISEIDKEGTGKMNFGDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVSEQEFLRIMKKTSLY
uniprot
proteins
function
FUNCTION: Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.; FUNCTION: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. {ECO:0000269|PubMed:22307388, ECO:0000305|PubMed:23591820}.
uniprot
proteins
mass_dalton
19738
uniprot
proteins
protein_family
Centrin family
uniprot
proteins
pubmed
10854409
uniprot
proteins
pubmed
11279143
uniprot
proteins
pubmed
12176356
uniprot
proteins
pubmed
12578356
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15356003
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
15964821
uniprot
proteins
pubmed
16411764
uniprot
proteins
pubmed
16533048
uniprot
proteins
pubmed
16627479
uniprot
proteins
pubmed
16760425
uniprot
proteins
pubmed
16956364
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17154534
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22307388
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23591820
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
32110738
uniprot
proteins
pubmed
32946374
uniprot
proteins
pubmed
36702832
uniprot
proteins
pubmed
37934472
uniprot
proteins
pubmed
8248209
uniprot
proteins
sequence_length
172
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:37934472}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:32110738, ECO:0000269|PubMed:32946374, ECO:0000269|PubMed:37934472}. Nucleus envelope {ECO:0000269|PubMed:23591820}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:23591820}. Nucleus {ECO:0000305}. Note=Localizes to the inner scaffold in the central region of centrioles and to the distal end of centrioles. {ECO:0000269|PubMed:37934472}.
uniprot
proteins