Sdhb
entrez
67680
canonical
uniprot
Q9CQA3
canonical
ensembl
ENSMUSG00000009863
resolver
ensp
ENSMUSP00000010007
resolver
ensp
ENSMUSP00000259758
resolver
enst
ENSMUST00000010007
resolver
genesymbol
Sdhb
resolver
uniprot
Q3TF82
resolver
uniprot
Q9DC91
resolver
uniprot_entry
SDHB_MOUSE
resolver
uniprot_sec
Q3TF82
resolver
uniprot_sec
Q9DC91
resolver
activity_regulation
ACTIVITY REGULATION: Enol-oxaloacetate inhibits the succinate dehydrogenase activity. {ECO:0000250|UniProtKB:Q3T189}.
uniprot
proteins
amino_acid_sequence
MAATVGVSLKRGFPAAVLGRVGLQFQACRGAQTAAAAAPRIKKFAIYRWDPDKTGDKPRMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTDLSKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEDREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSVYRCHTIMNCTQTCPKGLNPGKAIAEIKKMMATYKEKRALA
uniprot
proteins
ec_number
1.1.5.-
uniprot
proteins
ec_number
1.3.5.1
uniprot
proteins
function
FUNCTION: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity). {ECO:0000250|UniProtKB:P21912, ECO:0000250|UniProtKB:Q3T189}.
uniprot
proteins
mass_dalton
31814
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
uniprot
proteins
protein_family
Succinate dehydrogenase/fumarate reductase iron-sulfur protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
sequence_length
282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9YHT2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9YHT2}; Matrix side {ECO:0000250|UniProtKB:Q9YHT2}.
uniprot
proteins