Tpi1
entrez
21991
canonical
uniprot
P17751
canonical
ensembl
ENSMUSG00000023456
resolver
ensp
ENSMUSP00000130858
resolver
genesymbol
Tpi1
resolver
genesymbol_syn
Tpi
resolver
uniprot
Q3TJH2
resolver
uniprot
Q3UC04
resolver
uniprot
Q3UKG9
resolver
uniprot
Q64513
resolver
uniprot
Q9CVF9
resolver
uniprot
Q9CWE7
resolver
uniprot_entry
TPIS_MOUSE
resolver
uniprot_sec
Q3TJH2
resolver
uniprot_sec
Q3UC04
resolver
uniprot_sec
Q3UKG9
resolver
uniprot_sec
Q64513
resolver
uniprot_sec
Q9CVF9
resolver
uniprot_sec
Q9CWE7
resolver
amino_acid_sequence
MAPTRKFFVGGNWKMNGRKKCLGELICTLNAANVPAGTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDLGATWVVLGHSERRHVFGESDELIGQKVSHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVNDGVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ
uniprot
proteins
ec_number
4.2.3.3
uniprot
proteins
ec_number
5.3.1.1
uniprot
proteins
function
FUNCTION: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000250|UniProtKB:P00939}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}.
uniprot
proteins
mass_dalton
26713
uniprot
proteins
mutagenesis
MUTAGEN 163; /note="L->Q: 50% reduced activity."; /evidence="ECO:0000269|PubMed:7739600"; MUTAGEN 193; /note="L->Q: 50% reduced activity."; /evidence="ECO:0000269|PubMed:7739600
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. {ECO:0000255|PROSITE-ProRule:PRU10127}.; PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. {ECO:0000255|PROSITE-ProRule:PRU10127}.
uniprot
proteins
protein_family
Triosephosphate isomerase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16800626
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2377473
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7739600
uniprot
proteins
pubmed
9445485
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU10127}.
uniprot
proteins