Cplx4
entrez
225644
canonical
uniprot
Q80WM3
canonical
ensembl
ENSMUSG00000024519
resolver
ensp
ENSMUSP00000025397
resolver
enst
ENSMUST00000025397
resolver
genesymbol
Cplx4
resolver
uniprot
Q8C8Y0
resolver
uniprot
Q91WE5
resolver
uniprot_entry
CPLX4_MOUSE
resolver
uniprot_sec
Q8C8Y0
resolver
uniprot_sec
Q91WE5
resolver
amino_acid_sequence
MAFFVKNMISNQVKNLGFGGGSEEKKEEGGTSDPAAAKGMTREEYEEYQKQMIEEKMERDAAFTQKKAERACLRVHLRDKYRLPKSEMDETQIQLAGDDVDLPEDLRKMVDEDQDEEEEKDSILGQLQNLQNMDLDTIKEKAQATFTEIKQSAEQKCSVM
uniprot
proteins
function
FUNCTION: Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (PubMed:19386896). Required for the maintenance of synaptic ultrastructure in the adult retina (PubMed:19386896). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (PubMed:15911881, PubMed:19386896, PubMed:27335398). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (PubMed:22694764, PubMed:27335398). {ECO:0000269|PubMed:15911881, ECO:0000269|PubMed:19386896, ECO:0000269|PubMed:22694764, ECO:0000269|PubMed:27335398}.
uniprot
proteins
mass_dalton
18351
uniprot
proteins
post_translational_modification
PTM: Farnesylation mediates presynaptic targeting and is important for function in neurotransmitter release. {ECO:0000269|PubMed:15911881}.
uniprot
proteins
protein_family
Complexin/synaphin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15911881
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19386896
uniprot
proteins
pubmed
22694764
uniprot
proteins
pubmed
27335398
uniprot
proteins
sequence_length
160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000269|PubMed:15911881, ECO:0000269|PubMed:22694764}. Cell membrane {ECO:0000269|PubMed:15911881}; Lipid-anchor {ECO:0000269|PubMed:15911881}. Note=Enriched at the synaptic terminal. {ECO:0000269|PubMed:15911881}.
uniprot
proteins