GCKR
entrez
2646
canonical
uniprot
Q14397
canonical
ensembl
ENSG00000084734
resolver
ensp
ENSP00000264717
resolver
ensp
ENSP00000780008
resolver
enst
ENST00000264717
resolver
genesymbol
GCKR
resolver
hgnc
HGNC:4196
resolver
uniprot
A0A0C4DFN2
resolver
uniprot
A1L4C2
resolver
uniprot
B4DPQ2
resolver
uniprot
Q53RY6
resolver
uniprot
Q99522
resolver
uniprot_entry
A0A0C4DFN2_HUMAN
resolver
uniprot_entry
GCKR_HUMAN
resolver
uniprot_sec
A1L4C2
resolver
uniprot_sec
B4DPQ2
resolver
uniprot_sec
Q53RY6
resolver
uniprot_sec
Q99522
resolver
amino_acid_sequence
MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEIFQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISVGLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQKAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFERAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDVRGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQTIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISITWPLLFFEYEGNFIQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLRAIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEAVRSALAGPGQKRTADPLEILEPDVQ
uniprot
proteins
function
FUNCTION: Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:23621087, PubMed:23733961). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10456334). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed:23621087, PubMed:23733961). {ECO:0000269|PubMed:10456334, ECO:0000269|PubMed:23621087, ECO:0000269|PubMed:23733961}.
uniprot
proteins
mass_dalton
68685
uniprot
proteins
mutagenesis
MUTAGEN 326..327; /note="KK->TT: No effect on inhibition of glucokinase."; /evidence="ECO:0000269|PubMed:23621087"; MUTAGEN 413; /note="D->A: Impairs inhibition of glucokinase."; /evidence="ECO:0000269|PubMed:23733961"; MUTAGEN 450..451; /note="KK->TT: Impairs inhibition of glucokinase."; /evidence="ECO:0000269|PubMed:23621087"; MUTAGEN 463..465; /note="LLF->ALA: Abolishes interaction with GCK. Abolishes inhibition of GCK."; /evidence="ECO:0000269|PubMed:23733961
uniprot
proteins
protein_family
GCKR family
uniprot
proteins
pubmed
10456334
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18556336
uniprot
proteins
pubmed
18678614
uniprot
proteins
pubmed
19643913
uniprot
proteins
pubmed
23621087
uniprot
proteins
pubmed
23733961
uniprot
proteins
pubmed
8589523
uniprot
proteins
pubmed
9570959
uniprot
proteins
sequence_length
625
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10456334}. Nucleus {ECO:0000269|PubMed:10456334}. Mitochondrion {ECO:0000250|UniProtKB:Q07071}. Note=Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000269|PubMed:10456334}.
uniprot
proteins