SLC7A2
entrez
6542
canonical
uniprot
P52569
canonical
ensembl
ENSG00000003989
resolver
ensp
ENSP00000004531
resolver
ensp
ENSP00000381164
resolver
ensp
ENSP00000419140
resolver
ensp
ENSP00000419873
resolver
ensp
ENSP00000430464
resolver
ensp
ENSP00000578598
resolver
ensp
ENSP00000578599
resolver
ensp
ENSP00000578600
resolver
ensp
ENSP00000578601
resolver
ensp
ENSP00000578602
resolver
ensp
ENSP00000578603
resolver
enst
ENST00000470360
resolver
enst
ENST00000908539
resolver
enst
ENST00000908540
resolver
enst
ENST00000908541
resolver
enst
ENST00000908543
resolver
enst
ENST00000908544
resolver
genesymbol
SLC7A2
resolver
genesymbol_syn
ATRC2
resolver
genesymbol_syn
CAT2
resolver
hgnc
HGNC:11060
resolver
uniprot
A0A9H4ATX5
resolver
uniprot
B7ZL54
resolver
uniprot
O15291
resolver
uniprot
O15292
resolver
uniprot
Q14CQ6
resolver
uniprot
Q6NSZ7
resolver
uniprot
Q86TC6
resolver
uniprot_entry
A0A9H4ATX5_HUMAN
resolver
uniprot_entry
CTR2_HUMAN
resolver
uniprot_sec
B7ZL54
resolver
uniprot_sec
O15291
resolver
uniprot_sec
O15292
resolver
uniprot_sec
Q14CQ6
resolver
uniprot_sec
Q6NSZ7
resolver
uniprot_sec
Q86TC6
resolver
amino_acid_sequence
MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLFCPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFSYGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF
uniprot
proteins
function
FUNCTION: Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed:28684763, PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity). {ECO:0000250|UniProtKB:P18581, ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.; FUNCTION: [Isoform 1]: Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). Shows a much higher affinity for L-arginine and L-homoarginine than isoform 2. {ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.; FUNCTION: [Isoform 2]: Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). {ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.
uniprot
proteins
mass_dalton
71673
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
protein_family
Cationic amino acid transporter (CAT) (TC 2.A.3.3) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28684763
uniprot
proteins
pubmed
8954799
uniprot
proteins
pubmed
9174363
uniprot
proteins
sequence_length
658
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9174363}; Multi-pass membrane protein {ECO:0000269|PubMed:9174363}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..59; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 64..84; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 164..184; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 249..269; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 290..309; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 340..360; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 387..407; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 411..431; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 491..511; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 525..549; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 558..578; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 583..603; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins