Dusp1
entrez
114856
canonical
uniprot
Q64623
canonical
ensembl
ENSRNOG00000069024
resolver
ensembl
ENSRNOG00055002861
resolver
ensembl
ENSRNOG00055018497
resolver
ensembl
ENSRNOG00060003253
resolver
ensembl
ENSRNOG00065010710
resolver
ensp
ENSRNOP00000088885
resolver
ensp
ENSRNOP00055003316
resolver
ensp
ENSRNOP00055025383
resolver
ensp
ENSRNOP00060003937
resolver
ensp
ENSRNOP00065013292
resolver
enst
ENSRNOT00000110433
resolver
enst
ENSRNOT00055004476
resolver
enst
ENSRNOT00055031429
resolver
enst
ENSRNOT00060005349
resolver
enst
ENSRNOT00065017348
resolver
genesymbol
Dusp1
resolver
genesymbol_syn
Cl100
resolver
genesymbol_syn
Mkp1
resolver
genesymbol_syn
Ptpn16
resolver
uniprot
Q548G6
resolver
uniprot
Q63683
resolver
uniprot_entry
DUS1_RAT
resolver
uniprot_entry
Q63683_RAT
resolver
uniprot_sec
Q548G6
resolver
amino_acid_sequence
MVMEVGILDAGGLRALLRERAAQCLLLDCRSFFAFNAGHIVGSVNVRFSTIVRRRAKGAMGLEHIVPNTELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARSTQVFFLQGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILSFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKDAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHPTNSALNYLQSPITTSPSC
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. {ECO:0000250|UniProtKB:P28563}.
uniprot
proteins
mass_dalton
39541
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation. {ECO:0000250|UniProtKB:P28563}.; PTM: 'Lys-48'-linked polyubiquitinated by NEURL3, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q91790}.
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
11423551
uniprot
proteins
pubmed
15527789
uniprot
proteins
pubmed
19103603
uniprot
proteins
pubmed
8106404
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91790}.
uniprot
proteins