Cdk16
entrez
18555
canonical
uniprot
Q04735
canonical
ensembl
ENSMUSG00000031065
resolver
ensp
ENSMUSP00000033380
resolver
ensp
ENSMUSP00000111021
resolver
genesymbol
Cdk16
resolver
genesymbol_syn
Crk5
resolver
genesymbol_syn
Pctaire1
resolver
genesymbol_syn
Pctk1
resolver
uniprot
Q3TM24
resolver
uniprot
Q543G3
resolver
uniprot_entry
CDK16_MOUSE
resolver
uniprot_entry
Q3TM24_MOUSE
resolver
uniprot_entry
Q543G3_MOUSE
resolver
amino_acid_sequence
MDRMKKIKRQLSMTLRGGRGIDKTNGVPEQIGLDESGGGGGSDLGEAPTRIAPGELRSVRGPLSSAPEIVHEDMKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNVINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFRTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDARKHPFFLSLGERIHKLPDTTSIFALKEVQLQKEANIRSTSMPDSGRPAFRVVDTEF
uniprot
proteins
ec_number
2.7.11.22
uniprot
proteins
function
FUNCTION: Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Can phosphorylate CCNY at 'Ser-336' (in vitro) (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development. {ECO:0000250, ECO:0000269|PubMed:16461345, ECO:0000269|PubMed:21335063, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}.
uniprot
proteins
mass_dalton
55914
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="S->A,D: Does not affect interaction with CCNYl1."; /evidence="ECO:0000269|PubMed:26305884"; MUTAGEN 78; /note="S->A: Increases interaction with CCNYl1."; /evidence="ECO:0000269|PubMed:26305884"; MUTAGEN 95; /note="S->A: Abolishes phosphorylation by CDK5. Impairs normal dendrite development."; /evidence="ECO:0000269|PubMed:21335063"; MUTAGEN 110; /note="S->A,D: Reduces interaction with CCNYL1."; /evidence="ECO:0000269|PubMed:26305884"; MUTAGEN 119; /note="S->A: Reduces interaction with CCNYL1."; /evidence="ECO:0000269|PubMed:26305884"; MUTAGEN 146; /note="S->A,D: Abolishes interaction with CCNYl1. Decreases protein kinase activity."; /evidence="ECO:0000269|PubMed:26305884"; MUTAGEN 153; /note="S->A: Increases interaction with CCNYl1."; /evidence="ECO:0000269|PubMed:26305884"; MUTAGEN 153; /note="S->D: Reduces interaction with CCNYL1."; /evidence="ECO:0000269|PubMed:26305884"; MUTAGEN 175; /note="T->A: Reduces interaction with CCNYL1."; /evidence="ECO:0000269|PubMed:26305884"; MUTAGEN 175; /note="T->D: Increasse interaction with CCNYL1."; /evidence="ECO:0000269|PubMed:26305884"; MUTAGEN 194; /note="K->R: Does not affect interaction with CCNYl1."; /evidence="ECO:0000269|PubMed:26305884"; MUTAGEN 480; /note="S->A,D: Does not affect interaction with CCNYl1."; /evidence="ECO:0000269|PubMed:26305884
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of CDK16 is essential for the binding of CCNY, but also essential for the regulation of CDK16 kinase activity (By similarity). Phosphorylation of CDK16 is essential for the binding of CCNYl1, but also essential for the regulation of CDK16 kinase activity (PubMed:26305884). Ser-146 and Ser-153 are the critical sites for the binding of CCNYL1 and for modulating CDK16 kinase activity (PubMed:26305884). Phosphorylation at Ser-153 inhibits kinase activity (By similarity). {ECO:0000250|UniProtKB:Q00536, ECO:0000269|PubMed:26305884}.
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
1437147
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16461345
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21335063
uniprot
proteins
pubmed
22184064
uniprot
proteins
pubmed
22796189
uniprot
proteins
pubmed
22798068
uniprot
proteins
pubmed
26305884
uniprot
proteins
pubmed
8444355
uniprot
proteins
pubmed
9197417
uniprot
proteins
sequence_length
496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26305884}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q63686}. Cell membrane {ECO:0000269|PubMed:26305884}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q00536}; Cytoplasmic side {ECO:0000250|UniProtKB:Q00536}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q63686}. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY. {ECO:0000250|UniProtKB:Q00536}.
uniprot
proteins