Nbr1
entrez
303554
canonical
uniprot
Q501R9
canonical
ensembl
ENSRNOG00000020730
resolver
ensp
ENSRNOP00000028149
resolver
ensp
ENSRNOP00000071486
resolver
ensp
ENSRNOP00000080729
resolver
ensp
ENSRNOP00000085324
resolver
ensp
ENSRNOP00000104389
resolver
enst
ENSRNOT00000077942
resolver
enst
ENSRNOT00000115139
resolver
enst
ENSRNOT00000153438
resolver
genesymbol
Nbr1
resolver
uniprot
A0A0G2K0K7
resolver
uniprot
A0A8I6G713
resolver
uniprot
A0ABK0LLP3
resolver
uniprot
Q9JHG4
resolver
uniprot_entry
A0A0G2K0K7_RAT
resolver
uniprot_entry
A0A8I6G713_RAT
resolver
uniprot_entry
A0ABK0LLP3_RAT
resolver
uniprot_entry
NBR1_RAT
resolver
uniprot_sec
Q9JHG4
resolver
amino_acid_sequence
MEPQVTLNVTFKNETQSFLVSDPENTTWADVEAMVKVSFDLNTIQIKYLDEENEEISINSQGEYEEALKMANIKQGNQLQMQVHEGCHVVDEVLPQTVVEKQATARTGKKPLAHYSSLVRVLGSDMKTTEEPTAEARSPVPCDTDKPQDKPPDWFTSYLEMFREQVVKETVEKLEQRLQEKLVLQKPPFSSSPSEVSMPISEEETLFLPENQFSWHIACSHCQKRIVGVRYQCSLCPSYNICEDCEAGPYSHDTNHILLKFRRPVVISSEPFFYSKYPTPRLPAALEQVRLQKQVDKNFVKAEKQRLRAEKKQRKAEVKELKKQLKLHRKIHLWNSIHGLQSPKSPLGRPESLLQSNTLMLPLQPCAPVMPTLSAAFVDENLPDGTHLQPGTKFIKHWRMKNTGNVKWSADTKLKFMWGNLTLASTEKKDVLVPCLKAGHIGVVSVEFIAPTLEGTYTLHWRLSHKGQQFGPRVWCSIIVDPFPSSESPVNLERDGISSSKADDFTCEQEEAFLLAEEEIPLGEVTKQTEGTGSSAPQKTQHAASERELYIPSVDLLTAQDLLSFELLDINIVQELERVPHNTPVDVTPRMSPLPHDSPLIEKPGLGRIQEESEGAGLKASPDSTVLTKRKAETPASVEETEEDLSGTQFVCETVIRSLTLDAAPDHNPPCRQRSPQRELQLYSTEEQQPLMLPGFCRKDSSLKFALPEEGPHGDEREEIVHIAEEEAIEEEDVQDEEVQSQSSASSEDYIIILPECFDTSRPLGDSMYSSALSQPGLERGAEGEPGIESGQEPAEARERLPERESQPKEQSISDILTTSQHLDTVPLVPEVAGLPAALSRSAPCGQYEAPRVDSPVTIQEVLPVPDHVRGEPRGSTGLANSRQKSCDHSRHHNGSSIAGGLVKGALSVAASAYKALFSGPPVTAQPVISEDQTAALMAHLFEMGFCDRQLNLRLLRKHNHNILQVVTELLQVNNNDWYSHRY
uniprot
proteins
function
FUNCTION: Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis. Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (By similarity). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). {ECO:0000250|UniProtKB:P97432, ECO:0000250|UniProtKB:Q14596}.
uniprot
proteins
mass_dalton
109829
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3A; this phosphorylation inhibits NBR1 involvement in the formation of ubiquitinated protein aggregates. {ECO:0000250|UniProtKB:Q14596}.
uniprot
proteins
pubmed
11179671
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15802564
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
983
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14596}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q14596}. Lysosome {ECO:0000250|UniProtKB:Q14596}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:15802564}. Note=In cardiac muscles localizes to the sarcomeric M line (PubMed:15802564). Is targeted to lysosomes for degradation (By similarity). {ECO:0000250|UniProtKB:Q14596, ECO:0000269|PubMed:15802564}.
uniprot
proteins