TFRC
entrez
7037
canonical
uniprot
P02786
canonical
ensembl
ENSG00000072274
resolver
ensp
ENSP00000353224
resolver
ensp
ENSP00000376197
resolver
ensp
ENSP00000390133
resolver
ensp
ENSP00000513646
resolver
ensp
ENSP00000513650
resolver
ensp
ENSP00000513651
resolver
ensp
ENSP00000513654
resolver
ensp
ENSP00000513655
resolver
ensp
ENSP00000543456
resolver
ensp
ENSP00000586380
resolver
ensp
ENSP00000636740
resolver
ensp
ENSP00000636742
resolver
ensp
ENSP00000636744
resolver
ensp
ENSP00000636745
resolver
enst
ENST00000360110
resolver
enst
ENST00000392396
resolver
enst
ENST00000420415
resolver
enst
ENST00000698280
resolver
enst
ENST00000698285
resolver
enst
ENST00000698286
resolver
enst
ENST00000698291
resolver
enst
ENST00000873397
resolver
enst
ENST00000916321
resolver
enst
ENST00000966681
resolver
enst
ENST00000966683
resolver
enst
ENST00000966685
resolver
enst
ENST00000966686
resolver
genesymbol
TFRC
resolver
hgnc
HGNC:11763
resolver
uniprot
A0A8V8TM46
resolver
uniprot
A8K6Q8
resolver
uniprot
B7Z2I6
resolver
uniprot
D3DXB0
resolver
uniprot
G3V0E5
resolver
uniprot
Q1HE24
resolver
uniprot
Q59G55
resolver
uniprot
Q9UCN0
resolver
uniprot
Q9UCU5
resolver
uniprot
Q9UDF9
resolver
uniprot
Q9UK21
resolver
uniprot_entry
A0A8V8TM46_HUMAN
resolver
uniprot_entry
A8K6Q8_HUMAN
resolver
uniprot_entry
B7Z2I6_HUMAN
resolver
uniprot_entry
G3V0E5_HUMAN
resolver
uniprot_entry
TFR1_HUMAN
resolver
uniprot_sec
D3DXB0
resolver
uniprot_sec
Q1HE24
resolver
uniprot_sec
Q59G55
resolver
uniprot_sec
Q9UCN0
resolver
uniprot_sec
Q9UCU5
resolver
uniprot_sec
Q9UDF9
resolver
uniprot_sec
Q9UK21
resolver
amino_acid_sequence
MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPKRCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSKVWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRKQNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 46 (IMD46) [MIM:616740]: An autosomal recessive primary immunodeficiency disorder characterized by early-onset chronic diarrhea, recurrent infections, hypo- or agammaglobulinemia, normal lymphocyte counts, intermittent neutropenia, and intermittent thrombocytopenia. {ECO:0000269|PubMed:26642240}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738, PubMed:41772062). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (By similarity). {ECO:0000250|UniProtKB:Q62351, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:26642240, ECO:0000269|PubMed:3568132}.; FUNCTION: (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. {ECO:0000269|PubMed:17287727, ECO:0000269|PubMed:18268337}.; FUNCTION: (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762, ECO:0000269|PubMed:36779763}.; FUNCTION: (Microbial infection) Acts as a host entry factor for SARS-CoV, MERS-CoV and SARS-CoV-2 viruses that hijack the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762}.; FUNCTION: (Microbial infection) Acts as a receptor for Plasmodium vivax. {ECO:0000269|PubMed:29302006}.
uniprot
proteins
mass_dalton
84871
uniprot
proteins
mutagenesis
MUTAGEN 9..12; /note="FSNL->YTRF: Only 80% as active as wild-type receptor."; MUTAGEN 20..34; /note="YTRFSLARQVDGDNS->PPGYSLARQVDYTRF: No influence on endocytic uptake of the receptor."; MUTAGEN 20..23; /note="YTRF->PPGY: Only 16% as active as wild-type receptor."; /evidence="ECO:0000269|PubMed:8408022"; MUTAGEN 20; /note="Y->C: Only 35% as active as wild-type receptor."; /evidence="ECO:0000269|PubMed:2298808, ECO:0000269|PubMed:2327986, ECO:0000269|PubMed:8408022"; MUTAGEN 20; /note="Y->G: Only 20% as active as wild-type receptor."; /evidence="ECO:0000269|PubMed:2298808, ECO:0000269|PubMed:2327986, ECO:0000269|PubMed:8408022"; MUTAGEN 21; /note="T->F: Only 88% as active as wild-type receptor."; /evidence="ECO:0000269|PubMed:8408022"; MUTAGEN 21; /note="T->TA: Only 14% as active as wild-type receptor."; /evidence="ECO:0000269|PubMed:8408022"; MUTAGEN 21; /note="T->TAA: Only 19% as active as wild-type receptor."; /evidence="ECO:0000269|PubMed:8408022"; MUTAGEN 23; /note="F->Y: Only 48% as active as wild-type receptor."; /evidence="ECO:0000269|PubMed:8408022"; MUTAGEN 31..34; /note="GDNS->YTRF: 2-fold increase of the endocytic uptake of the receptor."; MUTAGEN 39; /note="K->R: Loss of DTX2-mediated ubiquitination."; /evidence="ECO:0000269|PubMed:41772062"; MUTAGEN 47..50; /note="NADN->YTRF: 1.27-fold increase of the endocytic uptake of the receptor."; MUTAGEN 149; /note="E->A: Significantly reduces interaction with P.vivax RBP2b. No effect on binding to transferrin."; /evidence="ECO:0000269|PubMed:29950717"; MUTAGEN 208; /note="R->A: Reduces interaction with P.vivax RBP2b. No effect on binding to transferrin."; /evidence="ECO:0000269|PubMed:29950717"; MUTAGEN 211; /note="Y->A: Significantly reduces interaction with P.vivax RBP2b. No effect on binding to transferrin."; /evidence="ECO:0000269|PubMed:29950717"; MUTAGEN 214; /note="E->A: Reduces interaction with P.vivax RBP2b. No effect on binding to transferrin."; /evidence="ECO:0000269|PubMed:29950717"; MUTAGEN 217; /note="Missing: Abolishes interaction with P.vivax RBP2b. No effect on binding to transferrin."; /evidence="ECO:0000269|PubMed:29950717"; MUTAGEN 294; /note="E->A: Significantly reduces interaction with P.vivax RBP2b. No effect on binding to transferrin."; /evidence="ECO:0000269|PubMed:29950717"; MUTAGEN 348; /note="N->A: No significant effect on interaction with P.vivax RBP2b. No effect on binding to transferrin."; /evidence="ECO:0000269|PubMed:29950717"; MUTAGEN 574; /note="K->A: Reduces interaction with P.vivax RBP2b. No effect on binding to transferrin."; /evidence="ECO:0000269|PubMed:29950717"; MUTAGEN 578; /note="E->A: No significant effect on interaction with P.vivax RBP2b. No effect on binding to transferrin."; /evidence="ECO:0000269|PubMed:29950717"; MUTAGEN 619; /note="L->A: 20-fold reduced affinity for transferrin receptor. No binding to HFE."; MUTAGEN 622; /note="V->A: No significant effect on binding to transferrin nor HFE."; MUTAGEN 623; /note="R->A: No significant effect on binding to transferrin nor HFE."; MUTAGEN 629; /note="R->A: >5-fold reduced affinity for transferrin. >10-fold reduced affinity for HFE."; MUTAGEN 640; /note="Q->A: No effect on binding to transferrin. >10-fold reduced affinity for HFE."; MUTAGEN 641; /note="W->A: No significant effect on binding to transferrin nor HFE."; MUTAGEN 643; /note="Y->A: 20-fold reduced affinity for transferrin. No binding to HFE."; MUTAGEN 644; /note="S->A: No significant effect on binding to transferrin nor HFE."; MUTAGEN 646; /note="R->A,H: No binding to transferrin."; /evidence="ECO:0000269|PubMed:10377239"; MUTAGEN 646; /note="R->K: 5% binding to transferrin."; /evidence="ECO:0000269|PubMed:10377239"; MUTAGEN 647; /note="G->A: Large effect on affinity for transferrin. 4-fold reduced affinity for HFE."; /evidence="ECO:0000269|PubMed:10377239"; MUTAGEN 648; /note="D->A: 16% binding to transferrin."; /evidence="ECO:0000269|PubMed:10377239"; MUTAGEN 648; /note="D->E: 57% binding to transferrin."; /evidence="ECO:0000269|PubMed:10377239"; MUTAGEN 650; /note="F->Q: >5-fold reduced affinity for transferrin. >10-fold reduced affinity for HFE.
uniprot
proteins
post_translational_modification
PTM: Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation (PubMed:26214738). Stearoylation does not affect iron uptake (PubMed:26214738). {ECO:0000269|PubMed:26214738}.; PTM: N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. {ECO:0000269|PubMed:1421756, ECO:0000269|PubMed:1421757, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:3582362}.; PTM: Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).; PTM: Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. {ECO:0000269|PubMed:3582362}.; PTM: Ubiquitinated via 'Lys-27'-linked chains, leading to enhanced degradation. {ECO:0000269|PubMed:41772062}.
uniprot
proteins
protein_family
M28B subfamily
uniprot
proteins
protein_family
Peptidase M28 family
uniprot
proteins
pubmed
10377239
uniprot
proteins
pubmed
10531064
uniprot
proteins
pubmed
11702220
uniprot
proteins
pubmed
11800564
uniprot
proteins
pubmed
1380674
uniprot
proteins
pubmed
1421756
uniprot
proteins
pubmed
1421757
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16325581
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
17287727
uniprot
proteins
pubmed
18268337
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
1871153
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2229063
uniprot
proteins
pubmed
2298808
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2327986
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2507316
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26214738
uniprot
proteins
pubmed
26642240
uniprot
proteins
pubmed
29302006
uniprot
proteins
pubmed
29950717
uniprot
proteins
pubmed
3568132
uniprot
proteins
pubmed
3582362
uniprot
proteins
pubmed
36779762
uniprot
proteins
pubmed
36779763
uniprot
proteins
pubmed
37158588
uniprot
proteins
pubmed
41772062
uniprot
proteins
pubmed
6090955
uniprot
proteins
pubmed
6094009
uniprot
proteins
pubmed
7780197
uniprot
proteins
pubmed
7864799
uniprot
proteins
pubmed
8408022
uniprot
proteins
pubmed
8631371
uniprot
proteins
pubmed
9358047
uniprot
proteins
pubmed
9782058
uniprot
proteins
sequence_length
760
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.; SUBCELLULAR LOCATION: [Transferrin receptor protein 1, serum form]: Secreted {ECO:0000269|PubMed:17081065}.
uniprot
proteins
transmembrane_region
TRANSMEM 68..88; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins