LIME1
entrez
54923
canonical
uniprot
Q9H400
canonical
ensembl
ENSG00000203896
resolver
ensp
ENSP00000309521
resolver
ensp
ENSP00000477561
resolver
enst
ENST00000480139
resolver
genesymbol
LIME1
resolver
genesymbol_syn
LIME
resolver
hgnc
HGNC:26016
resolver
uniprot
A0A087WT39
resolver
uniprot
E1P5K5
resolver
uniprot
E1P5K6
resolver
uniprot
Q5JWJ2
resolver
uniprot
Q6XYB3
resolver
uniprot
Q9NX69
resolver
uniprot_entry
A0A087WT39_HUMAN
resolver
uniprot_entry
LIME1_HUMAN
resolver
uniprot_sec
E1P5K5
resolver
uniprot_sec
E1P5K6
resolver
uniprot_sec
Q5JWJ2
resolver
uniprot_sec
Q6XYB3
resolver
uniprot_sec
Q9NX69
resolver
amino_acid_sequence
MGLPVSWAPPALWVLGCCALLLSLWALCTACRRPEDAVAPRKRARRQRARLQGSATAAEASLLRRTHLCSLSKSDTRLHELHRGPRSSRALRPASMDLLRPHWLEVSRDITGPQAAPSAFPHQELPRALPAAAATAGCAGLEATYSNVGLAALPGVSLAASPVVAEYARVQKRKGTHRSPQEPQQGKTEVTPAAQVDVLYSRVCKPKRRDPGPTTDPLDPKGQGAILALAGDLAYQTLPLRALDVDSGPLENVYESIRELGDPAGRSSTCGAGTPPASSCPSLGRGWRPLPASLP
uniprot
proteins
function
FUNCTION: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:14610046}.
uniprot
proteins
mass_dalton
31288
uniprot
proteins
mutagenesis
MUTAGEN 145; /note="Y->F: No change in binding to LCK, CSK or FYN."; /evidence="ECO:0000269|PubMed:14610046"; MUTAGEN 167; /note="Y->F: Abolishes binding to CSK."; /evidence="ECO:0000269|PubMed:14610046"; MUTAGEN 200; /note="Y->F: Reduces binding to CSK."; /evidence="ECO:0000269|PubMed:14610046"; MUTAGEN 235; /note="Y->F: No change in binding to LCK, CSK or FYN."; /evidence="ECO:0000269|PubMed:14610046"; MUTAGEN 254; /note="Y->F: Abolishes binding to LCK and reduces binding to FYN."; /evidence="ECO:0000269|PubMed:14610046
uniprot
proteins
post_translational_modification
PTM: Palmitoylation of Cys-28 and Cys-31 is required for raft targeting. {ECO:0000269|PubMed:14610046}.; PTM: Phosphorylated on tyrosines upon TCR activation and/or CD4 coreceptor stimulation, or upon BCR stimulation; which leads to the recruitment of SH2-containing proteins. {ECO:0000269|PubMed:14610044, ECO:0000269|PubMed:14610046}.
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14610044
uniprot
proteins
pubmed
14610046
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16160011
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14610044, ECO:0000269|PubMed:14610046}; Single-pass type III membrane protein {ECO:0000269|PubMed:14610044, ECO:0000269|PubMed:14610046}. Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins