Slc8a1
entrez
20541
canonical
uniprot
P70414
canonical
ensembl
ENSMUSG00000054640
resolver
ensp
ENSMUSP00000083725
resolver
ensp
ENSMUSP00000126373
resolver
ensp
ENSMUSP00000132809
resolver
ensp
ENSMUSP00000157030
resolver
ensp
ENSMUSP00000157278
resolver
ensp
ENSMUSP00000159714
resolver
enst
ENSMUST00000086538
resolver
enst
ENSMUST00000163123
resolver
enst
ENSMUST00000234131
resolver
enst
ENSMUST00000235015
resolver
enst
ENSMUST00000249357
resolver
genesymbol
Slc8a1
resolver
genesymbol_syn
Ncx
resolver
uniprot
A0A3Q4EBU5
resolver
uniprot
A0A3Q4EH13
resolver
uniprot
A0AA74KSJ5
resolver
uniprot
G3X9J1
resolver
uniprot
Q27PY9
resolver
uniprot
Q68FL0
resolver
uniprot_entry
A0A3Q4EBU5_MOUSE
resolver
uniprot_entry
A0A3Q4EH13_MOUSE
resolver
uniprot_entry
A0AA74KSJ5_MOUSE
resolver
uniprot_entry
G3X9J1_MOUSE
resolver
uniprot_entry
NAC1_MOUSE
resolver
uniprot_entry
Q27PY9_MOUSE
resolver
uniprot_entry
Q68FL0_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by micromolar levels of Ca(2+). {ECO:0000250|UniProtKB:Q01728}.
uniprot
proteins
amino_acid_sequence
MLRLSLPPNVSMGFRLVALVALLFSHVDHITADTEAETGGNETTECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVSSPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPASKTEIEMDGKVVNSHVDNFLDGALVLEVDERDQDDEEARREMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNMEMAENDPVSKIFFEQGTYQCLENCGTVALTIMRRGGDLSTTVFVDFRTEDGTANAASDYEFTEGTVIFKPGETQKEIRVGIIDDDIFEEDENFLVHLSNVRVSSDVSEDGILESNHASSIACLGSPSTATITIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIIPYKTIEGTARGGGEDFEDTCGEPEFQNDEIVKTISVKVIDDEEYEKNKTFFIEIGEPRLVEMSEKKALLLNELGGFTLTGKEMYGQPIFRKVHARDHPIPSTVITISEEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIQESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSSLFVLLWLLYIFFSSLEAYCHIKGF
uniprot
proteins
function
FUNCTION: Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:8659820). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:8659820). In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum (PubMed:8659820). SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:10967099). Required for normal embryonic heart development and the onset of heart contractions (PubMed:10967099). {ECO:0000269|PubMed:10967099, ECO:0000269|PubMed:8659820, ECO:0000305}.
uniprot
proteins
mass_dalton
108035
uniprot
proteins
protein_family
Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family
uniprot
proteins
protein_family
SLC8 subfamily
uniprot
proteins
pubmed
10967099
uniprot
proteins
pubmed
12781968
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23506867
uniprot
proteins
pubmed
8659820
uniprot
proteins
sequence_length
970
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8659820}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 134..154; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 229..249; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 798..818; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 822..842; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 872..892; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 904..924; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 942..962; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins