Tnrc18
entrez
231861
canonical
uniprot
Q80WC3
canonical
ensembl
ENSMUSG00000039477
resolver
ensp
ENSMUSP00000114769
resolver
ensp
ENSMUSP00000227054
resolver
ensp
ENSMUSP00000227055
resolver
ensp
ENSMUSP00000227057
resolver
enst
ENSMUST00000151477
resolver
genesymbol
Tnrc18
resolver
genesymbol_syn
EG381742
resolver
genesymbol_syn
Kiaa1856
resolver
genesymbol_syn
Zfp469
resolver
uniprot
D3YV17
resolver
uniprot
Q1LZJ7
resolver
uniprot
Q52KG0
resolver
uniprot
Q69Z86
resolver
uniprot_entry
D3YV17_MOUSE
resolver
uniprot_entry
Q52KG0_MOUSE
resolver
uniprot_entry
TNC18_MOUSE
resolver
uniprot_sec
Q1LZJ7
resolver
uniprot_sec
Q69Z86
resolver
amino_acid_sequence
MDGRDFGPQRSVHGPPPPLLSGLAMDSHRVGAATAGRLPSSGLPGPPPPGKYMAGLNLHPHPGFSHLPSGLYPSYLHLNHLDPPSSGSPLLSQLGQPSIFDTQKDGFYLPAPGTLHAHTPSSRTPSGHSSGGPAKGSSREGTGKDRAGRGGDPPPLFGKKDPRAREEVSGPRGVVDLTQEARAEGRQDRGSSRLAERLSPFLAEVKAKGALQPSALSLCNGVVDAGLVAELGRGGAKEVARQEENARLLRRAEALLPAARPCGSPLPPPPPLPPKGPPAPPSSTPAGVYTVFREPGREHRVVAPTFVPSVEAFDERVGPIQIASQARDVRAREREPGRPGVLQGPPGSPRLERPEVLREKSSVIRSLKRPPPSDGPPAARSSRSSPDARAYLPPKELLKPEADPRPCERAPRGPSASAAQQAAKLFGLEPSRPPGPEHKWKPFELGNFATTQMAVLAAQHHHASRAEEEAAVATASKKAYLDPGGAMPRASATCGRPGADLHSAAHGPGEASAMQSLIKYSGSFAREAVAVRPGGCGKKSPFGGLGTMKPEPTPTSAGPPRAQARLTHPGVPTAGGGRQLKRDPERPESAKAFGREGSGAQGEAEVRHPPVGIAVAVARQKDSGSSSRLGPGLGDQERTLSLNNVKGHGRTDDECDRARHREDRLLGTRLDRDQEKLLRESKELADLARLHPTSCAPNGLNPNLMVTGGPTLAGSGRWSADPAAHLATNPWLPRSGSTSMWLAGHPYGLGPPSLHQGMAPAFPPGLGGSLPSAYQFVRDPQSGQLVVIPSDHLPHFAELMERAAVPPLWPALYPPGRSPLHHAQQLQLFSQQHFLRQQELLYLQQQAAQALELQRSAQLVERLKAQEHRTEMEEKISKRSLETTGKAGLSAAGPGLLPRKSAGLANGPAGSHGKAVSPPPSPRASPVTSLKAKVIQKVEDVSKPPAYTYPATPSSHPSSPPPASPPPTPGLTRKEEAPENVVEKKDLELEKETPSPFQALFTDIPPRYPFQALPPHYGRPYPFLLQPAAASDADGLAPDVPLPADGPERLALSPEDKPICLSPSKIPEPPRDSPEEEQLADREVKAEVEDIEEGPTELPPLESPLALPVPETMVAVSPAGGCGGSPLEAQALSTAGPGCREPSEVSDFAQVAEPQIELPSKTEHRMTALELGTQLTPEPLVETKEEPVEVPLDVPMEEPTTEAGPEDSLPQPSLTEPQPSLELSDCDLPVPEGQCLNLEAQEAVPAPASTCYLEETHSESLLPGLDDPLAGMNALAAAAELPQARPLPSLGPGVPAGEKLDTAPSLVLEHSFLQGITLLSEIAELELDRRGQEAADPEPNLVVRPSLESLLAASSHMLKEVLESPFSDPLKNLRLPRELNSNKKYSWMQKKEERMFAMKSSLEDMDALELDFRMRLAEVQRRYKEKQRELVKLQRRRDSGDRHEDAHRSLARRGPGRPRKRTHTLSALSPPCKRKSHSSSGKGLSSKSLLTSDDYDLGAGIRKRHKGPEEEQEALMGMGKARSRNQSWDDHDSSSDFMSQLKIKKKKMASDQEQLASKLDRALSLTKQDKLKSPFKFSDGPGGKPKTGGGCGRFLTQYDSLLGKDRKALAKGLGLSLKPSREGKHKRASKARKMEGGFQARGQPKSVHSPFASEVSSQSYNTDSDEDEDFLKNEWSAQGPSSSKLTSSLLCGMVPKNSKPATGPKLTKRGLAGPRTLKPKVVTSRKQSFCLLLREAEARSSFSDSSEEDSFDQDDSSEEEEEELEEEEEDEEEEGIGSYRLGAGEQALSPSLEESGLGLLARFAASALPSPVVGPPLSVVQLEAEQKARKKEERQSLLGTEFEYTDSESEVKVPKQSAAGLLRTKKGVGEPGQSLAAPGPGSRASGPSSPDKAKLVSEKGRKARKIRGPKEPGFEAGPEASDDDLWTRRRSERIFLHDASAAVQATSNTAPATKPSRCGRGGAPSPRKDTGRAKDRKDPRKKKRGKEAGSAATLPPPRVSTLPDSRAPHPGALATAKRSKAKARGKEAKKENRGKGGAVSKLMECMAAEEDFEANQDSSFSEDEHLPRGGATERPLTPAPRSCIIDKEELKDGLRVLIPLDDKLLYAGHVQTVHSPDIYRVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRFLPQGTRIAAYWSQQYRCLYPGTVVRGLLDLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKTSKDTGEVKEGAATGPQEATGGKARGRGRKPSTKAKADRAVVLEEGAATNEVPSAPLALEPISTPNSKKSTPEPVDKRARAPKARSISAQPSPVPPTFSSCPAPEPFGELPTPATAPLVTMPVTMPATRPKPKKARAAEGSGAKGPRRPGEDDELLVKLDHEGVMSPKSKKAKEALLLREDPGPGGWPESTGLLSLGSYSPAVGSSEPKATWPKGLDGDLTQEPGPGLPLEDPGNSKNPDKAQAEQDGAEESETTSSSSSSSSSSSSSSSSSSSSSSSSSGSETEGEEDAEKNREDGRGAGGRTCSAASSRASSPASSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDEEAAPAPAAGPSTQPALPTKVSKPPSKARSSAHSPGKKAPTTTQPPPQPPPQPQQTLQPKTQAGAGAKSRPKKREGVHLPTTKELAKRQRLPSVENRPKIAAFLPARQLWKWFGKPTQRRGMKGKARKLFYKAIVRGKEMIRIGDCAVFLSAGRPNLPYIGRIQSMWESWGNNMVVRVKWFYHPEETSPGKQFHEGQHWDQKSGHSLPAALRASSQRKDFMERALYQSSHVDENDVQTVSHKCLVVGLEQYEQMLKTKKYQDSEGLYYLAGTYEPTTGMIFSTDGVPVLC
uniprot
proteins
function
FUNCTION: Chromatin reader involved in the silencing of endogenous retroviruses (ERV) class-I elements, such as LTR12 (PubMed:15368895). Specifically binds histone H3 trimethylated at 'Lys-9' (H3K9me3) deposited by SETB1 at class-I ERV and directly mediates recruitment of corepressor complexes, such as Sin3-type and N-Cor complexes, leading to ERV silencing (By similarity). {ECO:0000250|UniProtKB:O15417, ECO:0000269|PubMed:15368895}.
uniprot
proteins
mass_dalton
307635
uniprot
proteins
mutagenesis
MUTAGEN 2768..2770; /note="WFY->AFA: Knockin mice show neonatal lethality. Surviving animals show dwarfism. Endogenous retroviruses (ERV) derepression is observed in cells."; /evidence="ECO:0000269|PubMed:37938770
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
37938770
uniprot
proteins
sequence_length
2878
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O15417}. Chromosome {ECO:0000250|UniProtKB:O15417}. Note=Specifically binds histone H3 trimethylated at 'Lys-9' (H3K9me3) at endogenous retroviruses (ERV) sites on chromatin. {ECO:0000250|UniProtKB:O15417}.
uniprot
proteins