Sde2
entrez
289315
canonical
uniprot
Q5BJN8
canonical
ensembl
ENSRNOG00000003247
resolver
ensp
ENSRNOP00000004350
resolver
ensp
ENSRNOP00000075283
resolver
enst
ENSRNOT00000004350
resolver
genesymbol
Sde2
resolver
uniprot
A0A8L2Q245
resolver
uniprot_entry
A0A8L2Q245_RAT
resolver
uniprot_entry
SDE2_RAT
resolver
amino_acid_sequence
MAEAAVLAWVRGPGTAWKALPCASVGCSVRDVIYRHCEEQEIPVECFFVKCNGVLVAAGDKVCHGAVYSLEPRLRGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWVKQQAEREAEKEQRRLERLQRKLAEPAHCFASPDYQRQCHEMAERLEDSVLKGMQAASSKVVSAEVTETRKRPNRSKTDQGAGAKKKRCFWLGMEGLEAAEGSSTGSSDDSEDDDHEDAPGTSGPSCCARENGSDGGEVAADSPGSVQSSGSGTRSESPKELQNPMTEPGQGILENTGTEPGETSTREHNERKTVTVTETEETPARKETESPEPTEKGQETGVIGEDRAAMALSGEDRKSIPAATPEGSNSGDTALGVEALDLSAFSCAAELELLGLERLKCALMALGLKCGGTLQERAARLFSVRGLSKELIDPTLFAKPSKGKKK
uniprot
proteins
function
FUNCTION: Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (By similarity). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (By similarity). {ECO:0000250|UniProtKB:Q6IQ49}.; FUNCTION: Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content (By similarity). May recruit CACTIN to the spliceosome (By similarity). {ECO:0000250|UniProtKB:O14113, ECO:0000250|UniProtKB:Q6IQ49}.; FUNCTION: Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (By similarity). Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (By similarity). {ECO:0000250|UniProtKB:Q6IQ49}.
uniprot
proteins
mass_dalton
48084
uniprot
proteins
post_translational_modification
PTM: Upon binding to PCNA, the N-terminal UBL (ubiquitin-like) propeptide is cleaved at Gly-77 by an unidentified deubiquitinating enzyme; the resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. {ECO:0000250|UniProtKB:Q6IQ49}.; PTM: Both SDE2-UBL and the mature SDE2 are polyubiquitinated. {ECO:0000250|UniProtKB:Q6IQ49}.
uniprot
proteins
protein_family
SDE2 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6IQ49}. Cytoplasm {ECO:0000250|UniProtKB:Q6IQ49}.
uniprot
proteins