Bmpr1a
entrez
12166
canonical
uniprot
P36895
canonical
ensembl
ENSMUSG00000021796
resolver
ensp
ENSMUSP00000035900
resolver
ensp
ENSMUSP00000185571
resolver
ensp
ENSMUSP00000185573
resolver
ensp
ENSMUSP00000185574
resolver
ensp
ENSMUSP00000185580
resolver
enst
ENSMUST00000049005
resolver
genesymbol
Bmpr1a
resolver
genesymbol_syn
Acvrlk3
resolver
genesymbol_syn
Bmpr
resolver
uniprot
Q53Z43
resolver
uniprot_entry
BMR1A_MOUSE
resolver
uniprot_entry
Q53Z43_MOUSE
resolver
amino_acid_sequence
MTQLYTYIRLLGACLFIISHVQGQNLDSMLHGTGMKSDLDQKKPENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLTSGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVVLISMAVCIVAMIIFSSCFCYKHYCKSISSRGRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDIPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
uniprot
proteins
ec_number
2.7.11.30
uniprot
proteins
function
FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149). Mediates induction of adipogenesis by GDF6 (PubMed:23527555). May promote the expression of HAMP, potentially via its interaction with BMP2 (PubMed:31800957). {ECO:0000269|PubMed:23527555, ECO:0000269|PubMed:24098149, ECO:0000269|PubMed:31800957}.
uniprot
proteins
mass_dalton
60063
uniprot
proteins
mutagenesis
MUTAGEN 73; /note="N->Q: Reduced glycosylation and increased protein stability; when associated with Q-314 and Q-373."; /evidence="ECO:0000269|PubMed:29415997"; MUTAGEN 314; /note="N->Q: Reduced glycosylation and increased protein stability; when associated with Q-373 and Q-373."; /evidence="ECO:0000269|PubMed:29415997"; MUTAGEN 373; /note="N->Q: Reduced glycosylation and increased protein stability; when associated with Q-73 and Q-314."; /evidence="ECO:0000269|PubMed:29415997
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:29415997}.; PTM: Ubiquitinated by the complex made of the adapter SMAD6 and the E3 ligase SMURF1, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q13950}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TGFB receptor subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23527555
uniprot
proteins
pubmed
24098149
uniprot
proteins
pubmed
29415997
uniprot
proteins
pubmed
31800957
uniprot
proteins
pubmed
7750489
uniprot
proteins
pubmed
7937936
uniprot
proteins
pubmed
8065329
uniprot
proteins
sequence_length
532
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P36898}; Single-pass type I membrane protein {ECO:0000255}. Cell surface {ECO:0000269|PubMed:29415997}.
uniprot
proteins
transmembrane_region
TRANSMEM 153..176; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins