IL15RA
entrez
3601
canonical
uniprot
Q13261
canonical
ensembl
ENSG00000134470
resolver
ensp
ENSP00000369306
resolver
ensp
ENSP00000369312
resolver
ensp
ENSP00000380420
resolver
ensp
ENSP00000380421
resolver
ensp
ENSP00000380422
resolver
ensp
ENSP00000380426
resolver
ensp
ENSP00000431529
resolver
ensp
ENSP00000435454
resolver
ensp
ENSP00000435995
resolver
ensp
ENSP00000521478
resolver
ensp
ENSP00000521484
resolver
enst
ENST00000397248
resolver
genesymbol
IL15RA
resolver
hgnc
HGNC:5978
resolver
uniprot
A0A0A0MS77
resolver
uniprot
B4E2C2
resolver
uniprot
G8CVM3
resolver
uniprot
Q3B769
resolver
uniprot
Q5JVA1
resolver
uniprot
Q5JVA2
resolver
uniprot
Q5JVA4
resolver
uniprot
Q6B0J2
resolver
uniprot
Q7LDR4
resolver
uniprot
Q7Z609
resolver
uniprot_entry
A0A0A0MS77_HUMAN
resolver
uniprot_entry
G8CVM3_HUMAN
resolver
uniprot_entry
I15RA_HUMAN
resolver
uniprot_sec
B4E2C2
resolver
uniprot_sec
Q3B769
resolver
uniprot_sec
Q5JVA1
resolver
uniprot_sec
Q5JVA2
resolver
uniprot_sec
Q5JVA4
resolver
uniprot_sec
Q6B0J2
resolver
uniprot_sec
Q7LDR4
resolver
uniprot_sec
Q7Z609
resolver
amino_acid_sequence
MAPRRARGCRTLGLPALLLLLLLRPPATRGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSTVTTAGVTPQPESLSPSGKEPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTAKNWELTASASHQPPGVYPQGHSDTTVAISTSTVLLCGLSAVSLLACYLKSRQTPPLASVEMEAMEALPVTWGTSSRDEDLENCSHHL
uniprot
proteins
function
FUNCTION: High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed:15123770). Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910). {ECO:0000250|UniProtKB:Q60819, ECO:0000269|PubMed:10480910, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:8530383}.; FUNCTION: [Isoform 5]: Does not bind IL15. {ECO:0000269|PubMed:10480910}.; FUNCTION: [Isoform 6]: Does not bind IL15. {ECO:0000269|PubMed:10480910}.; FUNCTION: [Isoform 7]: Does not bind IL15. {ECO:0000269|PubMed:10480910}.; FUNCTION: [Isoform 8]: Does not bind IL15. {ECO:0000269|PubMed:10480910}.
uniprot
proteins
mass_dalton
28233
uniprot
proteins
post_translational_modification
PTM: N-glycosylated and O-glycosylated. {ECO:0000269|PubMed:10480910}.; PTM: A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor (PubMed:15265897). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor (PubMed:15265897). {ECO:0000269|PubMed:15265897}.
uniprot
proteins
pubmed
10480910
uniprot
proteins
pubmed
11714793
uniprot
proteins
pubmed
12114302
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15039446
uniprot
proteins
pubmed
15123770
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15265897
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16377614
uniprot
proteins
pubmed
17643103
uniprot
proteins
pubmed
21289315
uniprot
proteins
pubmed
8530383
uniprot
proteins
pubmed
9110174
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10480910}; Single-pass type I membrane protein {ECO:0000269|PubMed:10480910}. Nucleus membrane {ECO:0000269|PubMed:10480910}; Single-pass type I membrane protein {ECO:0000269|PubMed:10480910}. Cell surface {ECO:0000269|PubMed:15123770}. Note=Mainly found associated with the nuclear membrane.; SUBCELLULAR LOCATION: [Isoform 5]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.; SUBCELLULAR LOCATION: [Isoform 6]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.; SUBCELLULAR LOCATION: [Isoform 7]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.; SUBCELLULAR LOCATION: [Isoform 8]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.; SUBCELLULAR LOCATION: [Soluble interleukin-15 receptor subunit alpha]: Secreted, extracellular space {ECO:0000269|PubMed:15265897}.
uniprot
proteins
transmembrane_region
TRANSMEM 206..228; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins