Dnajc3
entrez
100037258
canonical
uniprot
Q91YW3
canonical
ensembl
ENSMUSG00000022136
resolver
ensp
ENSMUSP00000022734
resolver
enst
ENSMUST00000022734
resolver
genesymbol
Dnajc3
resolver
genesymbol_syn
Dnajc3a
resolver
genesymbol_syn
Dnajc3b
resolver
genesymbol_syn
P58ipk
resolver
uniprot
Q3UFV9
resolver
uniprot
Q60873
resolver
uniprot_entry
DNJC3_MOUSE
resolver
uniprot_entry
Q3UFV9_MOUSE
resolver
uniprot_sec
Q60873
resolver
amino_acid_sequence
MVAPGSVGSRLGAVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIALKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSEQEEKEAESQLVKADEMQRLRSQALDAFDGADYTAAITFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKSDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSVAEYTVRSKERICHCFSKDEKPVEAIRICSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYEAAQEHNENDQQIREGLEKAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEMRKKFDDGEDPLDAESQQGGGGNPFHRSWNSWQGFNPFSSGGPFRFKFHFN
uniprot
proteins
function
FUNCTION: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (PubMed:25329545). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity). {ECO:0000250|UniProtKB:Q13217, ECO:0000250|UniProtKB:Q27968, ECO:0000269|PubMed:12446838, ECO:0000269|PubMed:20184891, ECO:0000269|PubMed:25329545}.
uniprot
proteins
mass_dalton
57464
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="L->D: Reduces binding affinity for misfolded proteins by 40%."; /evidence="ECO:0000269|PubMed:20184891"; MUTAGEN 71; /note="Y->A: Reduces binding affinity for misfolded proteins by 40%."; /evidence="ECO:0000269|PubMed:20184891"; MUTAGEN 75; /note="Y->H: Reduces binding affinity for misfolded proteins by 40%."; /evidence="ECO:0000269|PubMed:20184891"; MUTAGEN 104; /note="F->A: Reduces binding affinity for misfolded proteins by 40%."; /evidence="ECO:0000269|PubMed:20184891"; MUTAGEN 186; /note="W->A: Doesn't affect binding of misfolded proteins."; /evidence="ECO:0000269|PubMed:20184891
uniprot
proteins
pubmed
12446838
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20184891
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25329545
uniprot
proteins
pubmed
8666242
uniprot
proteins
sequence_length
504
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:12446838}.
uniprot
proteins