H1-5
entrez
680522
canonical
uniprot
D3ZBN0
canonical
ensembl
ENSRNOG00000060355
resolver
ensembl
ENSRNOG00055005363
resolver
ensembl
ENSRNOG00060014587
resolver
ensembl
ENSRNOG00065021992
resolver
ensp
ENSRNOP00000074300
resolver
ensp
ENSRNOP00000111662
resolver
ensp
ENSRNOP00055006518
resolver
ensp
ENSRNOP00060019852
resolver
ensp
ENSRNOP00065030232
resolver
enst
ENSRNOT00000091688
resolver
enst
ENSRNOT00000151391
resolver
enst
ENSRNOT00055008604
resolver
enst
ENSRNOT00060024919
resolver
enst
ENSRNOT00065037436
resolver
genesymbol
H1-5
resolver
genesymbol_syn
H1f5
resolver
genesymbol_syn
HIf5
resolver
genesymbol_syn
Hist1h1b
resolver
uniprot_entry
H15_RAT
resolver
amino_acid_sequence
MSETAPAETTAPAPVEKSPAKKKTKKAGAAKRKATGPPVSELITKAVSASKERGGVSLPALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKVASGEAKPKAKKTGAAKAKKPTGATPKKPKKTAGAKKTVKKTPKKAKKPAAAGVKKVTKSPKKAKAAAKPKKATKSPARPKAVKSKASKPKVTKPKAAKPKAAKVKKAVSKKK
uniprot
proteins
function
FUNCTION: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. {ECO:0000250|UniProtKB:P10412}.
uniprot
proteins
mass_dalton
22649
uniprot
proteins
post_translational_modification
PTM: Deamidation of Asn-75 and Asn-76 by CTPS1 in response to DNA damage promotes subsequent acetylation of histone H1 at Lys-74 (H1K75ac). {ECO:0000250|UniProtKB:P10412}.; PTM: Acetylated at Lys-74 (H1K75ac) by EP300 following deamidation of Asn-75 and Asn-76 by CTPS1 in response to DNA damage, thereby increasing chromatin accessibility to facilitate the recruitment of DNA repair proteins. {ECO:0000250|UniProtKB:P10412}.; PTM: H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter. {ECO:0000250|UniProtKB:P16401}.; PTM: Citrullination at Arg-53 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. {ECO:0000250|UniProtKB:P43276}.
uniprot
proteins
protein_family
Histone H1/H5 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P16401}. Chromosome {ECO:0000250|UniProtKB:P16401}. Note=Mainly localizes with heterochromatin (By similarity). Associates with actively transcribed chromatin and not heterochromatin (By similarity). {ECO:0000250|UniProtKB:P16401}.
uniprot
proteins