ITGAX
entrez
3687
canonical
uniprot
P20702
canonical
ensembl
ENSG00000140678
resolver
ensp
ENSP00000268296
resolver
ensp
ENSP00000454623
resolver
enst
ENST00000268296
resolver
enst
ENST00000562522
resolver
genesymbol
ITGAX
resolver
genesymbol_syn
CD11C
resolver
hgnc
HGNC:6152
resolver
uniprot
H3BN02
resolver
uniprot
Q8IVA6
resolver
uniprot_entry
H3BN02_HUMAN
resolver
uniprot_entry
ITAX_HUMAN
resolver
uniprot_sec
Q8IVA6
resolver
amino_acid_sequence
MTRTRAALLLFTALATSLGFNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQEQDIVFLIDGSGSISSRNFATMMNFVRAVISQFQRPSTQFSLMQFSNKFQTHFTFEEFRRSSNPLSLLASVHQLQGFTYTATAIQNVVHRLFHASYGARRDAAKILIVITDGKKEGDSLDYKDVIPMADAAGIIRYAIGVGLAFQNRNSWKELNDIASKPSQEHIFKVEDFDALKDIQNQLKEKIFAIEGTETTSSSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEKYKVHNPTPLIVGSSIGGLLLLALITAVLYKVGFFKRQYKEMMEEANGQIAPENGTQTPSPPSEK
uniprot
proteins
function
FUNCTION: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Functions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis (PubMed:16985175). {ECO:0000269|PubMed:16985175}.
uniprot
proteins
mass_dalton
127829
uniprot
proteins
protein_family
Integrin alpha chain family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16985175
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
20033057
uniprot
proteins
pubmed
21763482
uniprot
proteins
pubmed
22844534
uniprot
proteins
pubmed
2303426
uniprot
proteins
pubmed
3327687
uniprot
proteins
pubmed
3549901
uniprot
proteins
sequence_length
1163
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16985175}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 1108..1128; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins