LRRC45
entrez
201255
canonical
uniprot
Q96CN5
canonical
ensembl
ENSG00000169683
resolver
ensp
ENSP00000306760
resolver
ensp
ENSP00000751676
resolver
enst
ENST00000306688
resolver
genesymbol
LRRC45
resolver
hgnc
HGNC:28302
resolver
uniprot_entry
LRC45_HUMAN
resolver
amino_acid_sequence
MEEFRRSYSRLCRESGAEPQEAVLQQLHQLPRGRLDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQASPVRTLSPPK
uniprot
proteins
function
FUNCTION: Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion (PubMed:24035387). Is probably involved in the early stages of ciliogenesis (PubMed:30131441, PubMed:39638757). Plays a role in the organization of centriolar satellites, likely by regulating the accumulation of centriolar satellite proteins, such as PCM1 and SSX2IP, at the centrosome (PubMed:30131441). {ECO:0000269|PubMed:24035387}.
uniprot
proteins
mass_dalton
75951
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NEK2 during misosis, phosphorylation reduces centrosomal localization which subsequently leads to centrosome separation. {ECO:0000269|PubMed:24035387}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24035387
uniprot
proteins
pubmed
30131441
uniprot
proteins
pubmed
30404835
uniprot
proteins
pubmed
31974111
uniprot
proteins
pubmed
39638757
uniprot
proteins
sequence_length
670
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24035387, ECO:0000269|PubMed:31974111}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:30131441}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:30131441}. Note=Localizes to the proteinaceous linker between the proximal ends of the centrioles (PubMed:24035387). Also localized to the distal appendages of the mother centriole (PubMed:30131441). {ECO:0000269|PubMed:24035387, ECO:0000269|PubMed:30131441}.
uniprot
proteins