Eef2k
entrez
13631
canonical
uniprot
O08796
canonical
ensembl
ENSMUSG00000035064
resolver
ensp
ENSMUSP00000046595
resolver
ensp
ENSMUSP00000102097
resolver
ensp
ENSMUSP00000102098
resolver
ensp
ENSMUSP00000286293
resolver
ensp
ENSMUSP00000286297
resolver
ensp
ENSMUSP00000286305
resolver
ensp
ENSMUSP00000286310
resolver
ensp
ENSMUSP00000286312
resolver
enst
ENSMUST00000047875
resolver
enst
ENSMUST00000106488
resolver
enst
ENSMUST00000106489
resolver
genesymbol
Eef2k
resolver
uniprot
Q7TPC7
resolver
uniprot
Q8BNP6
resolver
uniprot
Q8CEC8
resolver
uniprot_entry
EF2K_MOUSE
resolver
uniprot_entry
Q7TPC7_MOUSE
resolver
uniprot_entry
Q8BNP6_MOUSE
resolver
uniprot_entry
Q8CEC8_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent. {ECO:0000250|UniProtKB:P70531}.
uniprot
proteins
amino_acid_sequence
MADEDLIFCLEGVDGGRCSRAGHNADSDTDSDDDEGYFICPITDDHMSNQNVSSKVQSYYSNLTKTECGSTGSPASSFHFKEAWKHAIEKAKHMPDPWAEFHLEDIATEHATRHRYNAVTGEWLKDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRSVYFEDVQLQMEAKLWGEDYNRHKPPKQVDIMQMCIIELKDRPGQPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTEKGTDFGDGNLGVRGMALFFYSHACNRICQSMGLTPFDLSPREQDAVNQSTRLLQSAKTILRGTEEKCGSPRIRTLSSSRPPLLLRLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFGDLDNMGPRDHDRMDNHRDSENSGDSGYPSEKRSDLDDPEPREHGHSNGNRRHESDEDSLGSSGRVCVETWNLLNPSRLHLPRPSAVALEVQRLNALDLGRKIGKSVLGKVHLAMVRYHEGGRFCEKDEEWDRESAIFHLEHAADLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRHSMILVARAFDTGLNLSPDRCQDWSEALHWYNTALETTDCDEGGEYDGIQDEPQYALLAREAEMLLTGGFGLDKNPQRSGDLYTQAAEAAMEAMKGRLANQYYEKAEEAWAQMEE
uniprot
proteins
ec_number
2.7.11.20
uniprot
proteins
function
FUNCTION: Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation (PubMed:34815424, PubMed:9144159). Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive (PubMed:34815424, PubMed:9144159). In turn, the rate of protein synthesis is reduced (PubMed:34815424, PubMed:9144159). {ECO:0000269|PubMed:34815424, ECO:0000269|PubMed:9144159}.
uniprot
proteins
mass_dalton
81739
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated at multiple residues, Thr-347 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-397 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-77 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-358 or RPS6KA1 and RPS6KB1 at Ser-365 instead decrease EEF2K activity and promote protein synthesis (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Alpha-type protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34815424
uniprot
proteins
pubmed
9144159
uniprot
proteins
sequence_length
724
uniprot
proteins