Nrros
entrez
303875
canonical
uniprot
Q5BK65
canonical
ensembl
ENSRNOG00000001752
resolver
ensembl
ENSRNOG00060025033
resolver
ensembl
ENSRNOG00065020341
resolver
ensp
ENSRNOP00000109205
resolver
ensp
ENSRNOP00060035899
resolver
ensp
ENSRNOP00065027514
resolver
enst
ENSRNOT00000138184
resolver
enst
ENSRNOT00060043345
resolver
enst
ENSRNOT00065034362
resolver
genesymbol
Nrros
resolver
genesymbol_syn
Lrrc33
resolver
uniprot_entry
LRC33_RAT
resolver
amino_acid_sequence
MEFLPLWLCLGFHFLIVEWRSGRGTATAASQGGCKVVDRVADCRSLNLASVPSGLPAHSRMLVLDANPLRVLWNHSLQAYPRLEDLSLHSCHLDRISHWAFHEQGHLQNLVLADNRLSENYKESATALHTLLRLRRLDLSGNSLTEDMAALMLQNLSSLEVVSLARNTLMRLDDSVFEGLERLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNLPCIVDFSLTQLRFLNVSYNILEWFLAAREEAAFELEILDLSHNQLLFFPLLPQCGKLHTLLLQDNSMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVSLWEEFSSSDLSALRFLDMSQNQLRHLPDGFLKKTPSLSHLNLNQNCLTKLHIREHEPPGALTELDLSRNQLAELHLAPGLTGSLKNLRVFNLSSNQLLGVPTGLFHSASSITTLDMSHNQISLCPQTVPLDWEEPSSCVDFRNMASLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNWGILNGSVSPLSAVAPTLQVLSLRNVGLGSGAAEMDFSGFGNLRELDLSGNSLTSFPKFKGSSALQTLDLRRNSLTALPQRVVSEQPLRGLQTIYLSQNPYDCCGVEGWGALQHFKTIADLSMVTCNLSSKIIRVVELPEGIPQDCKWGQVDTGLFYLVLILPSCLTLLVASTVIFLTFKKPLLQVIKSRCHWSSIY
uniprot
proteins
function
FUNCTION: Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling. {ECO:0000250|UniProtKB:Q8BMT4}.
uniprot
proteins
mass_dalton
77070
uniprot
proteins
protein_family
LRRC32/LRRC33 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
692
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BMT4}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BMT4}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 651..671; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins