Oprk1
entrez
18387
canonical
uniprot
P33534
canonical
ensembl
ENSMUSG00000025905
resolver
ensp
ENSMUSP00000027038
resolver
ensp
ENSMUSP00000124030
resolver
ensp
ENSMUSP00000125105
resolver
ensp
ENSMUSP00000158863
resolver
enst
ENSMUST00000027038
resolver
enst
ENSMUST00000160339
resolver
enst
ENSMUST00000160777
resolver
enst
ENSMUST00000239100
resolver
genesymbol
Oprk1
resolver
uniprot
A0A5F8MP90
resolver
uniprot
Q14AL5
resolver
uniprot
Q3UVW8
resolver
uniprot_entry
A0A5F8MP90_MOUSE
resolver
uniprot_entry
OPRK_MOUSE
resolver
uniprot_entry
Q14AL5_MOUSE
resolver
uniprot_entry
Q3UVW8_MOUSE
resolver
amino_acid_sequence
MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV
uniprot
proteins
function
FUNCTION: G protein-coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269|PubMed:8393575, ECO:0000269|PubMed:9463367}.
uniprot
proteins
mass_dalton
42652
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
7499487
uniprot
proteins
pubmed
7733933
uniprot
proteins
pubmed
7802669
uniprot
proteins
pubmed
8393575
uniprot
proteins
pubmed
9463367
uniprot
proteins
sequence_length
380
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8393575, ECO:0000269|PubMed:9463367}; Multi-pass membrane protein {ECO:0000269|PubMed:8393575, ECO:0000269|PubMed:9463367}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..85; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 96..119; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 133..154; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 174..196; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 223..247; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 275..296; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 312..333; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins