ALS2CL
entrez
259173
canonical
uniprot
Q60I27
canonical
ensembl
ENSG00000178038
resolver
ensp
ENSP00000313670
resolver
ensp
ENSP00000413223
resolver
genesymbol
ALS2CL
resolver
hgnc
HGNC:20605
resolver
uniprot
Q32MA1
resolver
uniprot
Q6AI56
resolver
uniprot
Q6ZNC5
resolver
uniprot
Q6ZNC7
resolver
uniprot
Q6ZTL4
resolver
uniprot
Q86YD2
resolver
uniprot
Q8N9U1
resolver
uniprot
Q8NAL7
resolver
uniprot_entry
AL2CL_HUMAN
resolver
uniprot_sec
Q32MA1
resolver
uniprot_sec
Q6AI56
resolver
uniprot_sec
Q6ZNC5
resolver
uniprot_sec
Q6ZNC7
resolver
uniprot_sec
Q6ZTL4
resolver
uniprot_sec
Q86YD2
resolver
uniprot_sec
Q8N9U1
resolver
uniprot_sec
Q8NAL7
resolver
amino_acid_sequence
MCNPEEAALLRLEEVFSATLAHVNSLVLQPLLPAAPDPSDPWGRECLRLLQQLHKSSQQLWEVTEESLHSLQERLRYPDSTGLESLLLLRGADRVLQAHIEYIESYTSCMVVQAFQKAAKRRSEYWRGQRKALRQLLSGVSSEGSVGASLGQALHQPLAHHVQQYVLLLLSLGDTIGEHHPTRELVVNAVTLFGNLQSFMKQELDQAVATQALWHTLRGRLRDVLCTPAHRLLQDSQDVPVTVAPLRAERVLLFDDALVLLQGHNVHTFDLKLVWVDPGQDGCTFHLLTPEEEFSFCAKDSQGQAVWQWKVTWAVHQALHGKKDFPVLGAGLEPSQPPDCRCAEYTFQAEGRLCQATYEGEWCRGRPHGKGTLKWPDGRNHVGNFCQGLEHGFGIRLLPQASEDKFDCYKCHWREGSMCGYGICEYSTDEVYKGYFQEGLRHGFGVLESGPQAPQPFRYTGHWERGQRSGYGIEEDGDRGERYIGMWQAGQRHGPGVMVTQAGVCYQGTFQADKTVGPGILLSEDDSLYEGTFTRDLTLMGKGKVTFPNGFTLEGSFGSGAGRGLHTQGVLDTAALPPDPSSTCKRQLGVGAFPVESRWQGVYSPFRDFVCAGCPRDLQEALLGFDVQSSRELRRSQDYLSCERTHPEDSVGSMEDILEELLQHREPKALQLYLRKALSNSLHPLGKLLRTLMLTFQATYAGVGANKHLQELAQEEVKQHAQELWAAYRGLLRVALERKGQALEEDEDTETRDLQVHGLVLPLMLPSFYSELFTLYLLLHEREDSFYSQGIANLSLFPDTQLLEFLDVQKHLWPLKDLTLTSNQRYSLVRDKCFLSATECLQKIMTTVDPREKLEVLERTYGEIEGTVSRVLGREYKLPMDDLLPLLIYVVSRARIQHLGAEIHLIRDMMDPNHTGGLYDFLLTALESCYEHIQKEDMRLHRLPGHWHSRELW
uniprot
proteins
function
FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. {ECO:0000269|PubMed:15388334, ECO:0000269|PubMed:16473597, ECO:0000269|PubMed:17239822}.
uniprot
proteins
mass_dalton
107748
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15388334
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16473597
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17239822
uniprot
proteins
pubmed
17974005
uniprot
proteins
sequence_length
953
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15388334, ECO:0000269|PubMed:17239822}. Note=Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells.
uniprot
proteins