CD5
entrez
921
canonical
uniprot
P06127
canonical
ensembl
ENSG00000110448
resolver
ensp
ENSP00000342681
resolver
enst
ENST00000347785
resolver
genesymbol
CD5
resolver
genesymbol_syn
LEU1
resolver
hgnc
HGNC:1685
resolver
uniprot
A0N0P4
resolver
uniprot
A8K9I3
resolver
uniprot_entry
CD5_HUMAN
resolver
uniprot_sec
A0N0P4
resolver
uniprot_sec
A8K9I3
resolver
amino_acid_sequence
MPMGSLQPLATLYLLGMLVASCLGRLSWYDPDFQARLTRSNSKCQGQLEVYLKDGWHMVCSQSWGRSSKQWEDPSQASKVCQRLNCGVPLSLGPFLVTYTPQSSIICYGQLGSFSNCSHSRNDMCHSLGLTCLEPQKTTPPTTRPPPTTTPEPTAPPRLQLVAQSGGQHCAGVVEFYSGSLGGTISYEAQDKTQDLENFLCNNLQCGSFLKHLPETEAGRAQDPGEPREHQPLPIQWKIQNSSCTSLEHCFRKIKPQKSGRVLALLCSGFQPKVQSRLVGGSSICEGTVEVRQGAQWAALCDSSSARSSLRWEEVCREQQCGSVNSYRVLDAGDPTSRGLFCPHQKLSQCHELWERNSYCKKVFVTCQDPNPAGLAAGTVASIILALVLLVVLLVVCGPLAYKKLVKKFRQKKQRQWIGPTGMNQNMSFHRNHTATVRSHAENPTASHVDNEYSQPPRNSHLSAYPALEGALHRSSMQPDNSSDSDYDLHGAQRL
uniprot
proteins
function
FUNCTION: Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (PubMed:1384049, PubMed:1385158). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (PubMed:23376399). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (PubMed:27499044). {ECO:0000250|UniProtKB:P13379, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:23376399, ECO:0000269|PubMed:27499044}.
uniprot
proteins
mass_dalton
54578
uniprot
proteins
mutagenesis
MUTAGEN 446..447; /note="AS->VD: No loss of ERK1/2 activation and IL-10 production."; /evidence="ECO:0000269|PubMed:27499044"; MUTAGEN 452..454; /note="EYS->AAA: Strong reduction of ERK1/2 activation and IL-10 production."; /evidence="ECO:0000269|PubMed:27499044
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine, threonine and tyrosine residues following TCR stimulation (PubMed:1385158). Phosphorylated by LCK on Tyr-453 and Tyr-487 upon TCR engagement. {ECO:0000250|UniProtKB:P13379, ECO:0000269|PubMed:1385158}.
uniprot
proteins
pubmed
12522270
uniprot
proteins
pubmed
1384049
uniprot
proteins
pubmed
1385158
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
1711157
uniprot
proteins
pubmed
17322294
uniprot
proteins
pubmed
18339402
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23376399
uniprot
proteins
pubmed
27499044
uniprot
proteins
pubmed
3093892
uniprot
proteins
pubmed
8740779
uniprot
proteins
sequence_length
495
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P13379}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P13379}.
uniprot
proteins
transmembrane_region
TRANSMEM 373..402; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins