Phlda3
entrez
363989
canonical
uniprot
Q5PQT7
canonical
ensembl
ENSRNOG00000009068
resolver
ensembl
ENSRNOG00055022271
resolver
ensembl
ENSRNOG00060015777
resolver
ensembl
ENSRNOG00065020722
resolver
ensp
ENSRNOP00000011999
resolver
ensp
ENSRNOP00000111267
resolver
ensp
ENSRNOP00055031156
resolver
ensp
ENSRNOP00060021651
resolver
ensp
ENSRNOP00065028240
resolver
enst
ENSRNOT00000011999
resolver
enst
ENSRNOT00000149975
resolver
enst
ENSRNOT00055038266
resolver
enst
ENSRNOT00060026997
resolver
enst
ENSRNOT00065035123
resolver
genesymbol
Phlda3
resolver
genesymbol_syn
Tih1
resolver
uniprot_entry
PHLA3_RAT
resolver
amino_acid_sequence
MTAAATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFSRIKAVECVESTGRHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQSLGTGTLVS
uniprot
proteins
function
FUNCTION: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
13735
uniprot
proteins
protein_family
PHLDA3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
125
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
uniprot
proteins