Rdh16
entrez
19683
canonical
uniprot
O54909
canonical
ensembl
ENSMUSG00000069456
resolver
ensp
ENSMUSP00000071573
resolver
enst
ENSMUST00000071646
resolver
genesymbol
Rdh16
resolver
genesymbol_syn
Crad
resolver
genesymbol_syn
Crad1
resolver
genesymbol_syn
Rdh1
resolver
genesymbol_syn
Rdh6
resolver
uniprot_entry
RDH16_MOUSE
resolver
amino_acid_sequence
MWLYLVALVGLWTLLRFFRVRQVVSHLQDKYVFITGCDSGFGTLLARQLDRRGMRVLAACLTEKGAEELRNKTSDRLETVILDVTKTESIVTATQWVKEHVGNRGLWGLVNNAGISTPSGPNEWMKKQDFAHVLDVNLLGMIEVTLSMLPLVRKARGRVVNVSSVMGRVSLFGGGYCISKYGVEAFSDSLRRELSYFGVKVAIIEPGFFLTGVTSSARLCSNTQMLWDQTSSEIREIYGEKYLASYLKRLNKLDKRCNKDLSGVTDCMEHALTACHPRTRYSAGWDAKLFYLPLSYLPTFLVDALLYWTSLKPEKAL
uniprot
proteins
ec_number
1.1.1.105
uniprot
proteins
ec_number
1.1.1.209
uniprot
proteins
ec_number
1.1.1.315
uniprot
proteins
ec_number
1.1.1.53
uniprot
proteins
function
FUNCTION: Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction. {ECO:0000250|UniProtKB:O75452}.
uniprot
proteins
mass_dalton
35744
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000250|UniProtKB:O75452}.
uniprot
proteins
post_translational_modification
PTM: Not glycosylated. {ECO:0000269|PubMed:15355969}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
11279029
uniprot
proteins
pubmed
15355969
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16223484
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9407098
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11279029, ECO:0000269|PubMed:15355969, ECO:0000269|PubMed:16223484}; Single-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000269|PubMed:9407098}.
uniprot
proteins
transmembrane_region
TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins