SS18L1
entrez
26039
canonical
uniprot
O75177
canonical
ensembl
ENSG00000184402
resolver
ensp
ENSP00000333012
resolver
ensp
ENSP00000359885
resolver
ensp
ENSP00000748340
resolver
genesymbol
SS18L1
resolver
genesymbol_syn
CREST
resolver
genesymbol_syn
KIAA0693
resolver
hgnc
HGNC:15592
resolver
uniprot
A6NNE3
resolver
uniprot
A8K620
resolver
uniprot
B3KWR8
resolver
uniprot
B4DSR7
resolver
uniprot
E1P5H7
resolver
uniprot
Q5JXJ3
resolver
uniprot
Q6MZV9
resolver
uniprot
Q6NTH3
resolver
uniprot
Q6XYD9
resolver
uniprot
Q8NE69
resolver
uniprot
Q9BR55
resolver
uniprot
Q9H4K6
resolver
uniprot_entry
B4DSR7_HUMAN
resolver
uniprot_entry
CREST_HUMAN
resolver
uniprot_sec
A6NNE3
resolver
uniprot_sec
A8K620
resolver
uniprot_sec
B3KWR8
resolver
uniprot_sec
E1P5H7
resolver
uniprot_sec
Q5JXJ3
resolver
uniprot_sec
Q6MZV9
resolver
uniprot_sec
Q6NTH3
resolver
uniprot_sec
Q6XYD9
resolver
uniprot_sec
Q8NE69
resolver
uniprot_sec
Q9BR55
resolver
uniprot_sec
Q9H4K6
resolver
amino_acid_sequence
MSVAFASARPRGKGEVTQQTIQKMLDENHHLIQCILEYQSKGKTAECTQYQQILHRNLVYLATIADSNQNMQSLLPAPPTQNMNLGPGALTQSGSSQGLHSQGSLSDAISTGLPPSSLLQGQIGNGPSHVSMQQTAPNTLPTTSMSISGPGYSHAGPASQGVPMQGQGTIGNYVSRTNINMQSNPVSMMQQQAATSHYSSAQGGSQHYQGQSSIAMMGQGSQGSSMMGQRPMAPYRPSQQGSSQQYLGQEEYYGEQYSHSQGAAEPMGQQYYPDGHGDYAYQQSSYTEQSYDRSFEESTQHYYEGGNSQYSQQQAGYQQGAAQQQTYSQQQYPSQQSYPGQQQGYGSAQGAPSQYPGYQQGQGQQYGSYRAPQTAPSAQQQRPYGYEQGQYGNYQQ
uniprot
proteins
function
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
42990
uniprot
proteins
protein_family
SS18 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18331714
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity). {ECO:0000250}.
uniprot
proteins