Nps
entrez
100043254
canonical
uniprot
P0C0P8
canonical
ensembl
ENSMUSG00000073804
resolver
ensp
ENSMUSP00000095597
resolver
enst
ENSMUST00000097983
resolver
genesymbol
Nps
resolver
uniprot_entry
NPS_MOUSE
resolver
amino_acid_sequence
MIGSLKLSFVLALSLSVMHVLWCYPVLSSKVPGKPDYFLILLSSCPARLEGSDRLAFLKPILEKTSMKRSFRNGVGSGAKKTSFRRAKQ
uniprot
proteins
function
FUNCTION: Ligand for NPSR1. Binds to its receptor with nanomolar affinity and initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway. This results in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels (By similarity). In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction (By similarity). Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade (By similarity). Modulates arousal and anxiety. May play an important anorexigenic role (PubMed:16279934). {ECO:0000250|UniProtKB:P0C0P6, ECO:0000269|PubMed:16279934}.
uniprot
proteins
mass_dalton
9861
uniprot
proteins
pubmed
16279934
uniprot
proteins
sequence_length
89
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C0P7}.
uniprot
proteins