Htr4
entrez
25324
canonical
uniprot
Q62758
canonical
ensembl
ENSRNOG00000019134
resolver
ensp
ENSRNOP00000059569
resolver
ensp
ENSRNOP00000106833
resolver
enst
ENSRNOT00000168253
resolver
genesymbol
Htr4
resolver
uniprot
A0A9K3Y826
resolver
uniprot
A0ABK0LS68
resolver
uniprot
C4WYH2
resolver
uniprot
F1LS47
resolver
uniprot
O89034
resolver
uniprot
Q62757
resolver
uniprot
Q63006
resolver
uniprot_entry
5HT4R_RAT
resolver
uniprot_entry
A0A9K3Y826_RAT
resolver
uniprot_entry
A0ABK0LS68_RAT
resolver
uniprot_entry
C4WYH2_RAT
resolver
uniprot_sec
F1LS47
resolver
uniprot_sec
O89034
resolver
uniprot_sec
Q62757
resolver
uniprot_sec
Q63006
resolver
amino_acid_sequence
MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:10220570, PubMed:7796807). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity). {ECO:0000250|UniProtKB:Q13639, ECO:0000269|PubMed:10220570, ECO:0000269|PubMed:7796807}.
uniprot
proteins
mass_dalton
46107
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10220570
uniprot
proteins
pubmed
7656980
uniprot
proteins
pubmed
7796807
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13639}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:P97288}; Multi-pass membrane protein {ECO:0000255}. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with NHERF1 and EZR might target the protein to specialized subcellular regions, such as microvilli. {ECO:0000250|UniProtKB:P97288}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..44; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q13639"; TRANSMEM 55..78; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q13639"; TRANSMEM 93..117; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q13639"; TRANSMEM 134..157; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q13639"; TRANSMEM 189..212; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q13639"; TRANSMEM 258..283; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q13639"; TRANSMEM 291..314; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q13639
uniprot
proteins