NUDT4
entrez
11163
canonical
uniprot
Q9NZJ9
canonical
ensembl
ENSG00000173598
resolver
ensembl
ENSG00000177144
resolver
ensp
ENSP00000338352
resolver
ensp
ENSP00000406612
resolver
ensp
ENSP00000448032
resolver
ensp
ENSP00000449552
resolver
ensp
ENSP00000449724
resolver
enst
ENST00000548662
resolver
enst
ENST00000549992
resolver
genesymbol
NUDT4
resolver
genesymbol_syn
DIPP2
resolver
genesymbol_syn
KIAA0487
resolver
hgnc
HGNC:8051
resolver
uniprot
A0A0C4DGJ4
resolver
uniprot
B7Z916
resolver
uniprot
Q4AEJ6
resolver
uniprot
Q53EZ2
resolver
uniprot
Q68DD7
resolver
uniprot
Q9NPC5
resolver
uniprot
Q9NS30
resolver
uniprot
Q9NZK0
resolver
uniprot
Q9NZK1
resolver
uniprot_entry
A0A0C4DGJ4_HUMAN
resolver
uniprot_entry
NUDT4_HUMAN
resolver
uniprot_sec
B7Z916
resolver
uniprot_sec
Q4AEJ6
resolver
uniprot_sec
Q53EZ2
resolver
uniprot_sec
Q68DD7
resolver
uniprot_sec
Q9NPC5
resolver
uniprot_sec
Q9NS30
resolver
uniprot_sec
Q9NZK0
resolver
uniprot_sec
Q9NZK1
resolver
amino_acid_sequence
MMKFKPNQTRTYDREGFKKRAACLCFRSEQEDEVLLVSSSRYPDQWIVPGGGMEPEEEPGGAAVREVYEEAGVKGKLGRLLGIFENQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREWFKVEDAIKVLQCHKPVHAEYLEKLKLGCSPANGNSTVPSLPDNNALFVTAAQTSGLPSSVR
uniprot
proteins
ec_number
3.6.1.52
uniprot
proteins
ec_number
3.6.1.61
uniprot
proteins
function
FUNCTION: Cleaves the beta-phosphate from diphosphoinositol polyphosphates such as PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 (diphosphoinositol tetrakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10777568). Diadenosine polyphosphates, particularly Ap6A (P(1),P(6)-bis(5a-adenosyl) hexaphosphate) and Ap5A (P(1),P(5)-bis(5'-adenosyl) pentaphosphate) are downstream effectors of a signaling cascade that regulates cardiac KATP channels, can also be substrates, although with lower preference than the diphosphoinositol polyphosphates (PubMed:10777568). Can also catalyze the hydrolysis of 5-phosphoribose 1-diphosphate, generating the glycolytic activator ribose 1,5-bisphosphate (PubMed:12370170). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250|UniProtKB:Q8R2U6, ECO:0000269|PubMed:10777568, ECO:0000269|PubMed:12370170}.
uniprot
proteins
mass_dalton
20306
uniprot
proteins
protein_family
DIPP subfamily
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
10777568
uniprot
proteins
pubmed
12121577
uniprot
proteins
pubmed
12370170
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
9455484
uniprot
proteins
sequence_length
180
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12121577}.
uniprot
proteins