Gab2
entrez
84477
canonical
uniprot
Q9EQH1
canonical
ensembl
ENSRNOG00000011882
resolver
ensp
ENSRNOP00000016361
resolver
enst
ENSRNOT00000016361
resolver
genesymbol
Gab2
resolver
uniprot
F1LSR2
resolver
uniprot_entry
F1LSR2_RAT
resolver
uniprot_entry
GAB2_RAT
resolver
amino_acid_sequence
MSGGGGDDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNEHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEADMNKWVQSICQICGFNQAEESTDSLRNLSSASHGPRSSPAEFSSSQHLLRERKSSAPSHSSQPTLFTFEPPMTSHMQPALSTSAPQEYLYLHQCISRRTENSRSASFSQGTRQKSDTAVQKLAQSNGHCINGVSNQVHGFYSLPKPSRHNTEFKDSTYDLPRSLASHGHTKSSLTGSETDNEDVYTFKMPSNTLCREFGDLLVDNMDVPTTPLSAYQIPRTFTLDKNHNAMTVATSGDSAIAPPPRPPKPSQAETPRWGSPQQKPPIGENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPTRGSGESASWSAESPGKTAVGRSDSASSDENYVPMNPGSSTLLAMERAGDNSQSAYIPMGPGPHHFDPLGYPSTALPIHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPVTKSWSRINHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPRKSTGSVDYLALDFQPGSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL
uniprot
proteins
function
FUNCTION: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
73328
uniprot
proteins
post_translational_modification
PTM: Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling (By similarity). Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity). Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL (By similarity). {ECO:0000250}.; PTM: Dephosphorylated by PTPN11. {ECO:0000250}.
uniprot
proteins
protein_family
GAB family
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
665
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UQC2}. Cell membrane {ECO:0000250|UniProtKB:Q9UQC2}. Membrane raft {ECO:0000250|UniProtKB:Q9Z1S8}.
uniprot
proteins