SETD3
entrez
84193
canonical
uniprot
Q86TU7
canonical
ensembl
ENSG00000183576
resolver
ensp
ENSP00000327436
resolver
ensp
ENSP00000327910
resolver
ensp
ENSP00000526695
resolver
ensp
ENSP00000526696
resolver
ensp
ENSP00000607420
resolver
genesymbol
SETD3
resolver
genesymbol_syn
C14orf154
resolver
hgnc
HGNC:20493
resolver
uniprot
A0PJU3
resolver
uniprot
A5PLP0
resolver
uniprot
B4DZE8
resolver
uniprot
Q0VAQ2
resolver
uniprot
Q659C0
resolver
uniprot
Q86TU8
resolver
uniprot
Q96GY9
resolver
uniprot
Q9H5U5
resolver
uniprot_entry
SETD3_HUMAN
resolver
uniprot_sec
A0PJU3
resolver
uniprot_sec
A5PLP0
resolver
uniprot_sec
B4DZE8
resolver
uniprot_sec
Q0VAQ2
resolver
uniprot_sec
Q659C0
resolver
uniprot_sec
Q86TU8
resolver
uniprot_sec
Q96GY9
resolver
uniprot_sec
Q9H5U5
resolver
amino_acid_sequence
MGKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAEFVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHFTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSVRAKMAIKLRLGEKEILEKAVKSAAVNREYYRQQMEEKAPLPKYEESNLGLLESSVGDSRLPLVLRNLEEEAGVQDALNIREAISKAKATENGLVNGENSIPNGTRSENESLNQESKRAVEDAKGSSSDSTAGVKE
uniprot
proteins
ec_number
2.1.1.85
uniprot
proteins
function
FUNCTION: Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). {ECO:0000269|PubMed:30526847, ECO:0000269|PubMed:30626964, ECO:0000269|PubMed:30785395, ECO:0000269|PubMed:31388018, ECO:0000269|PubMed:31993215}.
uniprot
proteins
mass_dalton
67257
uniprot
proteins
mutagenesis
MUTAGEN 37..42; /note="SSPAPG->ASPAPA: Does not affect ubiquitination and degradation by the SCF(FBXW7) complex."; /evidence="ECO:0000269|PubMed:28442573"; MUTAGEN 181..185; /note="SEYDT->AEYDA: Decreased ubiquitination and degradation by the SCF(FBXW7) complex."; /evidence="ECO:0000269|PubMed:28442573"; MUTAGEN 215; /note="R->A: Decreased binding to actin and decreased protein-histidine N-methyltransferase activity."; /evidence="ECO:0000269|PubMed:30785395"; MUTAGEN 256; /note="N->A,V: Decreased binding to actin and decreased protein-histidine N-methyltransferase activity. Increased protein-lysine methyltransferase activity toward an actin mutant with a Lys instead of a His target residue. Increased protein-methionine methyltransferase activity toward an actin mutant with a Met instead of a His target residue."; /evidence="ECO:0000269|PubMed:30785395, ECO:0000269|PubMed:31388018, ECO:0000269|PubMed:32503840"; MUTAGEN 256; /note="N->F: Shows protein-lysine methyltransferase activity toward an actin mutant with a Lys instead of a His target residue; when associated with A-274."; /evidence="ECO:0000269|PubMed:31911441"; MUTAGEN 260..264; /note="TEDGS->AEDGA: Does not affect ubiquitination and degradation by the SCF(FBXW7) complex."; /evidence="ECO:0000269|PubMed:28442573"; MUTAGEN 274; /note="W->A: Shows protein-lysine methyltransferase activity toward an actin mutant with a Lys instead of a His target residue; when associated with F-256."; /evidence="ECO:0000269|PubMed:31911441"; MUTAGEN 313; /note="Y->A: Abolished protein-histidine N-methyltransferase activity."; /evidence="ECO:0000269|PubMed:30626964"; MUTAGEN 313; /note="Y->F: Strongly decreased binding to actin and decreased protein-histidine N-methyltransferase activity."; /evidence="ECO:0000269|PubMed:30785395"; MUTAGEN 316; /note="R->A: Decreased binding to actin and decreased protein-histidine N-methyltransferase activity."; /evidence="ECO:0000269|PubMed:30785395"; MUTAGEN 373..378; /note="TEPPIS->AEPPIA: Strongly decreased ubiquitination and degradation by the SCF(FBXW7) complex."; /evidence="ECO:0000269|PubMed:28442573"; MUTAGEN 512..517; /note="SSVGDS->ASVGDA: Does not affect ubiquitination and degradation by the SCF(FBXW7) complex."; /evidence="ECO:0000269|PubMed:28442573"; MUTAGEN 565..569; /note="SENES->AENEA: Does not affect ubiquitination and degradation by the SCF(FBXW7) complex."; /evidence="ECO:0000269|PubMed:28442573
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3B, which is required for recognition by the SCF(FBXW7) complex and subsequent degradation. {ECO:0000269|PubMed:28442573}.; PTM: Ubiquitinated by the SCF(FBXW7) complex following phosphorylation by GSK3B, leading to its degradation by the proteasome. {ECO:0000269|PubMed:28442573}.
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
SETD3 actin-histidine methyltransferase family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28442573
uniprot
proteins
pubmed
30526847
uniprot
proteins
pubmed
30626964
uniprot
proteins
pubmed
30785395
uniprot
proteins
pubmed
31388018
uniprot
proteins
pubmed
31911441
uniprot
proteins
pubmed
31993215
uniprot
proteins
pubmed
32503840
uniprot
proteins
sequence_length
594
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28442573, ECO:0000269|PubMed:30626964}. Nucleus {ECO:0000269|PubMed:28442573}. Note=Localizes mainly in the cytoplasm. {ECO:0000269|PubMed:28442573}.
uniprot
proteins