Kcnh2
entrez
117018
canonical
uniprot
O08962
canonical
ensembl
ENSRNOG00000009872
resolver
ensp
ENSRNOP00000013800
resolver
ensp
ENSRNOP00000073593
resolver
ensp
ENSRNOP00000104113
resolver
enst
ENSRNOT00000084826
resolver
enst
ENSRNOT00000171126
resolver
genesymbol
Kcnh2
resolver
genesymbol_syn
Erg
resolver
uniprot
A0ABK0LHI8
resolver
uniprot
A0ACM8Q4H8
resolver
uniprot
A6K570
resolver
uniprot
O08720
resolver
uniprot
Q6DKY7
resolver
uniprot_entry
A0ABK0LHI8_RAT
resolver
uniprot_entry
A0ACM8Q4H8_RAT
resolver
uniprot_entry
A6K570_RAT
resolver
uniprot_entry
KCNH2_RAT
resolver
uniprot_sec
O08720
resolver
uniprot_sec
Q6DKY7
resolver
amino_acid_sequence
MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPSTSWLASGRAKTFRLKLPALLALTARESPMRTGSTGSPGAPGAVVVDVDLTPAAPSSESLALDEVSAMDNHVAGLGPAEERRALVGPASASPVASIPGPHPSPRAQSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGALPLPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQAPDCGYACQPLAVVDLLVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPSSAELESGFNRQRKRKLSFRRRTDKDTEQPGEVSALGQGPARVGPGPSCRGQPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGDSPGGEPLTEDGEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPAPSLLNIPLSSPGRRSRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVGPVPTLTLDSLSQVSQFVAFEELPAGAPELPQDGPTRRLSLPGQLGALTSQPLHRHGSDPGS
uniprot
proteins
function
FUNCTION: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed:11212207, PubMed:9664620). Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization (PubMed:11212207, PubMed:9664620). Channel properties are modulated by cAMP and subunit assembly. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity (By similarity). {ECO:0000250|UniProtKB:Q12809, ECO:0000269|PubMed:11212207, ECO:0000269|PubMed:9664620}.
uniprot
proteins
mass_dalton
126952
uniprot
proteins
mutagenesis
MUTAGEN 630; /note="G->S: Dominant negative mutant; abolishes ERG current."; /evidence="ECO:0000269|PubMed:11212207
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction. {ECO:0000250|UniProtKB:Q12809}.
uniprot
proteins
protein_family
H (Eag) (TC 1.A.1.20) subfamily
uniprot
proteins
protein_family
Kv11.1/KCNH2 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10718922
uniprot
proteins
pubmed
11212207
uniprot
proteins
pubmed
14525949
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9012748
uniprot
proteins
pubmed
9664620
uniprot
proteins
sequence_length
1163
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q12809}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 406..426; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 453..473; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 498..518; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 523..543; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 550..570; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 641..661; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins