Srsf10
entrez
14105
canonical
uniprot
Q9R0U0
canonical
ensembl
ENSMUSG00000028676
resolver
ensp
ENSMUSP00000095455
resolver
ensp
ENSMUSP00000099603
resolver
ensp
ENSMUSP00000101479
resolver
ensp
ENSMUSP00000114564
resolver
ensp
ENSMUSP00000280822
resolver
ensp
ENSMUSP00000346050
resolver
enst
ENSMUST00000102544
resolver
genesymbol
Srsf10
resolver
genesymbol_syn
Fusip1
resolver
genesymbol_syn
Nssr
resolver
genesymbol_syn
Sfrs13a
resolver
genesymbol_syn
Srsf13a
resolver
uniprot
B1AV44
resolver
uniprot
B1AV45
resolver
uniprot
F8WGF3
resolver
uniprot
O70307
resolver
uniprot
O88468
resolver
uniprot
Q3TFP0
resolver
uniprot
Q3TGW7
resolver
uniprot
Q3UA07
resolver
uniprot
Q8CFZ1
resolver
uniprot
Q9R0T9
resolver
uniprot_entry
F8WGF3_MOUSE
resolver
uniprot_entry
Q3TFP0_MOUSE
resolver
uniprot_entry
Q3UA07_MOUSE
resolver
uniprot_entry
SRS10_MOUSE
resolver
uniprot_sec
B1AV44
resolver
uniprot_sec
B1AV45
resolver
uniprot_sec
O70307
resolver
uniprot_sec
O88468
resolver
uniprot_sec
Q3TGW7
resolver
uniprot_sec
Q8CFZ1
resolver
uniprot_sec
Q9R0T9
resolver
amino_acid_sequence
MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHSDNDRFKHRNRSFSRSKSNSRSRSKSQPKKEMKAKSRSRSASHTKTRGTSKTDSKTHYKSGSRYEKESRKKEPPRSKSQSRSQSRSRSKSRSRSWTSPKSSGH
uniprot
proteins
function
FUNCTION: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (By similarity). May be involved in regulation of alternative splicing in neurons (PubMed:10583508). {ECO:0000250|UniProtKB:O75494, ECO:0000269|PubMed:10583508}.
uniprot
proteins
mass_dalton
31301
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock. {ECO:0000250|UniProtKB:O75494}.
uniprot
proteins
protein_family
Splicing factor SR family
uniprot
proteins
pubmed
10583508
uniprot
proteins
pubmed
10779324
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9774382
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:10583508}.
uniprot
proteins