Tmem135
entrez
72759
canonical
uniprot
Q9CYV5
canonical
ensembl
ENSMUSG00000039428
resolver
ensp
ENSMUSP00000042783
resolver
ensp
ENSMUSP00000189619
resolver
enst
ENSMUST00000041968
resolver
genesymbol
Tmem135
resolver
uniprot
Q8BSY5
resolver
uniprot
Q8CCZ6
resolver
uniprot
Q8CE78
resolver
uniprot_entry
TM135_MOUSE
resolver
uniprot_sec
Q8BSY5
resolver
uniprot_sec
Q8CCZ6
resolver
uniprot_sec
Q8CE78
resolver
amino_acid_sequence
MAALSKSIPHNCYEIGHTWHPSCRVSFLQITWGALEESLRIYAPLYLIAAVLRKRKLEYYLYKLLPEILQSASFLTANGALYITFFCILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLATETLFRMGVARGTITTLRNGEVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSYSPETAYAKVEQKREKHKGTPRAMSIIALVRTLVDSVCKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTEPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIVAGFLAGVSMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPQADTIIYSISTAICFHAAVMEVQNLRPSYWKFLLRLTKGRFALMNRKALDVFGTGASREFHNFIPRLDPRYTVVTPELPIDFS
uniprot
proteins
function
FUNCTION: Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission (PubMed:27863209). May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L (PubMed:27863209). May be involved in peroxisome organization (By similarity). {ECO:0000250|UniProtKB:Q5U4F4, ECO:0000269|PubMed:27863209}.
uniprot
proteins
mass_dalton
52364
uniprot
proteins
protein_family
TMEM135 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17768142
uniprot
proteins
pubmed
21151927
uniprot
proteins
pubmed
27863209
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305|PubMed:27863209}; Multi-pass membrane protein {ECO:0000305}. Peroxisome membrane {ECO:0000305|PubMed:17768142}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 68..88; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 96..116; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 149..169; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 298..318; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 331..351; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins