KCNJ12
entrez
3768
canonical
uniprot
Q14500
canonical
ensembl
ENSG00000184185
resolver
ensp
ENSP00000328150
resolver
ensp
ENSP00000463778
resolver
ensp
ENSP00000574767
resolver
ensp
ENSP00000574768
resolver
ensp
ENSP00000574769
resolver
ensp
ENSP00000574770
resolver
ensp
ENSP00000574771
resolver
ensp
ENSP00000574772
resolver
ensp
ENSP00000588302
resolver
ensp
ENSP00000618771
resolver
ensp
ENSP00000618772
resolver
ensp
ENSP00000618773
resolver
enst
ENST00000331718
resolver
enst
ENST00000583088
resolver
enst
ENST00000904708
resolver
enst
ENST00000904709
resolver
enst
ENST00000904710
resolver
enst
ENST00000904711
resolver
enst
ENST00000904712
resolver
enst
ENST00000904713
resolver
enst
ENST00000918243
resolver
enst
ENST00000948712
resolver
enst
ENST00000948713
resolver
enst
ENST00000948714
resolver
genesymbol
KCNJ12
resolver
genesymbol_syn
IRK2
resolver
genesymbol_syn
KCNJN1
resolver
hgnc
HGNC:6258
resolver
uniprot
O43401
resolver
uniprot
Q15756
resolver
uniprot
Q8NG63
resolver
uniprot_entry
KCJ12_HUMAN
resolver
uniprot_sec
O43401
resolver
uniprot_sec
Q15756
resolver
uniprot_sec
Q8NG63
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphatidylinositol 4,5-biphosphate (PtdIns(4,5)P2) (PubMed:20921230). PtdIns(4,5)P2 binding to the cytoplasmic side of the channel triggers a conformation change leading to channel opening (By similarity). Inhibited by Ba(2+) (PubMed:7859381, PubMed:8647284). {ECO:0000250|UniProtKB:F1NHE9, ECO:0000269|PubMed:20921230, ECO:0000269|PubMed:7859381, ECO:0000269|PubMed:8647284}.
uniprot
proteins
amino_acid_sequence
MTAASRANPYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEPAEGRGRTPCVMQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYEVPSTPRCSAKDLVENKFLLPSANSFCYENELAFLSRDEEDEADGDQDGRSRDGLSPQARHDFDRLQAGGGVLEQRPYRRESEI
uniprot
proteins
function
FUNCTION: Inward rectifying potassium channel that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. {ECO:0000269|PubMed:12417321, ECO:0000269|PubMed:20921230, ECO:0000269|PubMed:7859381, ECO:0000269|PubMed:8647284}.
uniprot
proteins
mass_dalton
49001
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ12 subfamily
uniprot
proteins
pubmed
12032359
uniprot
proteins
pubmed
12417321
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20921230
uniprot
proteins
pubmed
21209095
uniprot
proteins
pubmed
7859381
uniprot
proteins
pubmed
8647284
uniprot
proteins
pubmed
9430667
uniprot
proteins
sequence_length
433
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:21209095}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:P52188}.
uniprot
proteins
transmembrane_region
TRANSMEM 78..104; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:F1NHE9"; TRANSMEM 156..183; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:F1NHE9
uniprot
proteins