Mov10
entrez
17454
canonical
uniprot
P23249
canonical
ensembl
ENSMUSG00000002227
resolver
ensp
ENSMUSP00000002297
resolver
ensp
ENSMUSP00000126897
resolver
ensp
ENSMUSP00000128246
resolver
ensp
ENSMUSP00000279200
resolver
ensp
ENSMUSP00000337214
resolver
enst
ENSMUST00000166979
resolver
enst
ENSMUST00000168015
resolver
genesymbol
Mov10
resolver
genesymbol_syn
Gb110
resolver
uniprot
E9PW39
resolver
uniprot
Q3UD86
resolver
uniprot
Q9DC64
resolver
uniprot_entry
E9PW39_MOUSE
resolver
uniprot_entry
MOV10_MOUSE
resolver
uniprot_entry
Q3UD86_MOUSE
resolver
uniprot_sec
Q9DC64
resolver
amino_acid_sequence
MPSKFSCRKLRETGQRFESFLAERGLDLETDRERLRTIYNHDFKPSYGTPAPGFSSMLYGMKIANLAFVTKTRVRFFKLDRWADVQLPEKRRIKPGSNISKQHRSLLARIFHDRAEYLHGKHGVDVEVQGPHEARDGQLLIHLDLNRKEVLTLRLRNGGSKPVTLTHLFPLCWTPQFVFYHGEQDLPCPLGPGESYELHIYCKTSIVGYFPATVLWELLGPGESGAEGAETFYIARFLAAVAHSPLAAQLKPTTPFKRPPRLTRNSVLTNRIEEGERPDRAKGYELELSLALGTYYPPILLRQLLPTLLQGPSIFTAPKEVAEIKAQLETTLKSRNYEVKLRLLLHLEELQMEHDIRHYDLDSVPMTWDPVDQNPRLLTLEVPGVAESRPSVLRGDHLFALLSSETQQDDPVTYKGFVHKVELDRVKLSFSTSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWVLWPMLFPVASRGVSLLPSDVKFKLYDRSLESNPEQLQAMKHIVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKTCCNWDAKKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLALKHGLGYSLLERLLAYNSLYKKGPNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVDRERFCRWEGLPQQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKQLLAPSSKKGKARLSPRNVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKENGGYTGCPFPAKLDLQQGQDLLQGLSKLSPSTSGPRRHQNLPQEREGEGGLPLQVEPEWRNEL
uniprot
proteins
ec_number
5.6.2.5
uniprot
proteins
function
FUNCTION: 5'-3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production. Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation. Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs. Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2. Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1. Facilitates LINE-1 uridylation by TUT4 and TUT7 (By similarity). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (PubMed:28662698). May function as a messenger ribonucleoprotein (mRNP) clearance factor (By similarity). {ECO:0000250|UniProtKB:Q9HCE1, ECO:0000269|PubMed:28662698}.
uniprot
proteins
mass_dalton
113583
uniprot
proteins
mutagenesis
MUTAGEN 531; /note="K->A: Abolishes inhibition of retrotransposition."; /evidence="ECO:0000269|PubMed:28662698
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the DCX(DCAF12) complex that specifically recognizes the glutamate-leucine (Glu-Leu) degron at the C-terminus, leading to its degradation. {ECO:0000269|PubMed:34065512}.
uniprot
proteins
protein_family
DNA2/NAM7 helicase family
uniprot
proteins
protein_family
SDE3 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1899287
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28662698
uniprot
proteins
pubmed
34065512
uniprot
proteins
pubmed
36001654
uniprot
proteins
pubmed
8065313
uniprot
proteins
sequence_length
1004
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000250|UniProtKB:Q9HCE1}. Nucleus {ECO:0000269|PubMed:28662698}. Cytoplasm {ECO:0000269|PubMed:28662698}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q9HCE1}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q9HCE1}. Note=In young mouse (P2) neurons, localizes both in nucleus and cytoplasm, but in the adulthood it is only cytoplasmic (PubMed:28662698). Co-enriched in cytoplasmic foci with TUT4 (By similarity). {ECO:0000250|UniProtKB:Q9HCE1, ECO:0000269|PubMed:28662698}.
uniprot
proteins