DPYSL2
entrez
1808
canonical
uniprot
Q16555
canonical
ensembl
ENSG00000092964
resolver
ensp
ENSP00000309539
resolver
ensp
ENSP00000427985
resolver
ensp
ENSP00000431117
resolver
enst
ENST00000521913
resolver
genesymbol
DPYSL2
resolver
genesymbol_syn
CRMP2
resolver
genesymbol_syn
ULIP2
resolver
hgnc
HGNC:3014
resolver
uniprot
A0A1C7CYX9
resolver
uniprot
A8K5H2
resolver
uniprot
B4DR31
resolver
uniprot
D3DSS7
resolver
uniprot
O00424
resolver
uniprot
Q59GB4
resolver
uniprot_entry
A0A1C7CYX9_HUMAN
resolver
uniprot_entry
DPYL2_HUMAN
resolver
uniprot_entry
Q59GB4_HUMAN
resolver
uniprot_sec
A8K5H2
resolver
uniprot_sec
B4DR31
resolver
uniprot_sec
D3DSS7
resolver
uniprot_sec
O00424
resolver
amino_acid_sequence
MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFSLSGAQIDDNIPRRTTQRIVAPPGGRANITSLG
uniprot
proteins
function
FUNCTION: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}.
uniprot
proteins
mass_dalton
62294
uniprot
proteins
mutagenesis
MUTAGEN 71; /note="D->N: Inhibits axon outgrowth formation in hippocampal neurons and decreases binding to CYFIP1."; /evidence="ECO:0000269|PubMed:16260607"; MUTAGEN 507; /note="S->A: No effect."; /evidence="ECO:0000269|PubMed:10757975"; MUTAGEN 509; /note="T->A: Greatly diminishes binding to 3F4 antibody."; /evidence="ECO:0000269|PubMed:10757975"; MUTAGEN 512; /note="T->A: No effect."; /evidence="ECO:0000269|PubMed:10757975"; MUTAGEN 514; /note="T->A: No effect."; /evidence="ECO:0000269|PubMed:10757975"; MUTAGEN 517; /note="S->A: No effect."; /evidence="ECO:0000269|PubMed:10757975"; MUTAGEN 518; /note="S->A: Greatly diminishes binding to 3F4 antibody."; /evidence="ECO:0000269|PubMed:10757975"; MUTAGEN 521; /note="T->A: No effect."; /evidence="ECO:0000269|PubMed:10757975"; MUTAGEN 522; /note="S->A: Greatly diminishes binding to 3F4 antibody."; /evidence="ECO:0000269|PubMed:10757975
uniprot
proteins
post_translational_modification
PTM: 3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509. {ECO:0000269|PubMed:10757975, ECO:0000269|PubMed:15466863}.; PTM: Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B. {ECO:0000250, ECO:0000269|PubMed:10757975, ECO:0000269|PubMed:15466863}.
uniprot
proteins
protein_family
Hydantoinase/dihydropyrimidinase family
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
pubmed
10574455
uniprot
proteins
pubmed
10757975
uniprot
proteins
pubmed
11477421
uniprot
proteins
pubmed
14685275
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15466863
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16260607
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17250651
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19235893
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19652227
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20801876
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7637782
uniprot
proteins
pubmed
8973361
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20801876}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20801876}. Membrane {ECO:0000269|PubMed:20801876}. Note=Tightly but non-covalently associated with membranes.
uniprot
proteins