Il36b
entrez
69677
canonical
uniprot
Q9D6Z6
canonical
ensembl
ENSMUSG00000026985
resolver
ensp
ENSMUSP00000028363
resolver
enst
ENSMUST00000028363
resolver
genesymbol
Il36b
resolver
genesymbol_syn
Fil1e
resolver
genesymbol_syn
Il1f8
resolver
uniprot
Q08EA6
resolver
uniprot
Q8R461
resolver
uniprot_entry
IL36B_MOUSE
resolver
uniprot_entry
Q08EA6_MOUSE
resolver
uniprot_sec
Q8R461
resolver
amino_acid_sequence
MMAFPPQSCVHVLPPKSIQMWEPNHNTMHGSSQSPRNYRVHDSQQMVWVLTGNTLTAVPASNNVKPVILSLIACRDTEFQDVKKGNLVFLGIKNRNLCFCCVEMEGKPTLQLKEVDIMNLYKERKAQKAFLFYHGIEGSTSVFQSVLYPGWFIATSSIERQTIILTHQRGKLVNTNFYIESEK
uniprot
proteins
function
FUNCTION: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF and IL-23, and activates p38 MAPK phosphorylation in BMDCs. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by T-helper 1 (Th1) cells, cultured CD4(+) T-cells and splenocytes. {ECO:0000250|UniProtKB:Q9NZH7, ECO:0000269|PubMed:21860022, ECO:0000269|PubMed:21965679}.
uniprot
proteins
mass_dalton
20878
uniprot
proteins
post_translational_modification
PTM: N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold). {ECO:0000269|PubMed:21965679}.
uniprot
proteins
protein_family
IL-1 family
uniprot
proteins
pubmed
11991723
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19717513
uniprot
proteins
pubmed
21860022
uniprot
proteins
pubmed
21965679
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NZH7}. Secreted {ECO:0000269|PubMed:19717513}. Note=Secreted upon LPS treatment followed by ATP-induced activation of P2rx7. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (By similarity). {ECO:0000250|UniProtKB:Q9NZH7, ECO:0000269|PubMed:19717513}.
uniprot
proteins