NKX1-2
entrez
390010
canonical
uniprot
Q9UD57
canonical
ensembl
ENSG00000229544
resolver
ensp
ENSP00000451945
resolver
enst
ENST00000451024
resolver
genesymbol
NKX1-2
resolver
genesymbol_syn
C10orf121
resolver
genesymbol_syn
NKX1.1
resolver
hgnc
HGNC:31652
resolver
uniprot_entry
NKX12_HUMAN
resolver
amino_acid_sequence
MLAWQDGGAKAAPSHHKISFSVLDILDPQKFTRAALPAVRPAPREARKSLAEVEAGKDASSRDPVRQLETPDAAGPGAGQASPLEGSEAEEEEDAEDPRRPRLRERAARLLPGLARSPDAPAGALASGEPCEDGGGGPVRSPPGSPGSPRPRRRRLEPNCAKPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADGAAQVGGGAPQPGAAGGGGGGGSGGSPGPPGTGALHFQTFPSYSAANVLFPSAASFPLTAAAPGSPFAPFLGPSYLTPFYAPRL
uniprot
proteins
function
FUNCTION: Transcriptional repressor. May play a role in early development as a Wnt/beta-catenin effector, hence controlling pluripotency and preimplantation development of embryonic stem cells. May promote adipogenesis in mesenchymal stem cells, possibly by inhibiting the expression of the antiadipogenic factor NR2F2. May inhibit osteoblastogenic differentiation. {ECO:0000250|UniProtKB:P42580}.
uniprot
proteins
mass_dalton
32381
uniprot
proteins
protein_family
NK-1 homeobox family
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
7518789
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P42580}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P42580}. Note=Specifically localizes to the nucleoli of oocytes and preimplantation embryos. {ECO:0000250|UniProtKB:P42580}.
uniprot
proteins