P85967
uniprot
P85967
canonical
activity_regulation
ACTIVITY REGULATION: [Gasdermin-C]: The full-length protein before cleavage is inactive: intramolecular interactions between N- and C-terminal domains mediate autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the released N-terminal moiety (Gasdermin-C, N-terminal) following cleavage by caspase CASP8. {ECO:0000250|UniProtKB:Q9BYG8}.
uniprot
proteins
amino_acid_sequence
MLYTFDQVSKDVVKKLQGKDLRPVRCLSDATKFRQFDILQKTPQSLFFKSEDTPVGYSLLQILEPNFPVPETEVSAPMPLKHITSQKWKADVDVKATIADGGASAEFVQSCGYDIEVQSRSIPDSKLESLQNRQGPWGKLLDKKLSFVTDCQMGRNNLYVVTEVFEVTKDTVVQGSSSIDLSGKALVSQLVKGEAQGQWQRETTDLVPIPKGAVLAYKKKQLVIENNTCAILLSANAKKKTFPGIFNFGMSSRSQTMEIVNSSWIDYIPPIGRIEEPVHLDFKYLEKEVFLRKEQLAMLSKDVQDVVFSNLLPMLSDSDVLFDLINMLELDQLGHMDGPAGLILDELRKNSSTPWIDLKGLILYLLQALMVLSDTQLDLLAQSMEMRILLQQRELVRSILEPNFKYPWNIPFTLQPQLLAPLQGEGLAITYELLKGCGLKMEPNSPRSTWDLEAKMPLSALYGILSCLQQLVEA
uniprot
proteins
function
FUNCTION: [Gasdermin-C]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering pyroptosis. {ECO:0000250|UniProtKB:Q9BYG8}.; FUNCTION: [Gasdermin-C, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis. Produced by the cleavage of gasdermin-C by caspase CASP8 in response to death signals. After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. {ECO:0000250|UniProtKB:Q9BYG8}.
uniprot
proteins
mass_dalton
53252
uniprot
proteins
post_translational_modification
PTM: Cleavage by CASP8 relieves autoinhibition by releasing the N-terminal moiety (Gasdermin-C, N-terminal) that initiates pyroptosis. {ECO:0000250|UniProtKB:Q9BYG8}.; PTM: Palmitoylated. {ECO:0000250|UniProtKB:Q9BYG8}.
uniprot
proteins
protein_family
Gasdermin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Gasdermin-C]: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BYG8}.; SUBCELLULAR LOCATION: [Gasdermin-C, N-terminal]: Cell membrane {ECO:0000250|UniProtKB:Q5Y4Y6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}.
uniprot
proteins