Q08125
uniprot
Q08125
canonical
amino_acid_sequence
MRMLLCLNVLTLSCVWAIAMEIPMSTVVKETLIQLSTHRALLTSNETMRLPVPTHKNHQLCIGEIFQGLDILKNQTVRGGTVEILFQNLSLIKKYIDGQKEKCGEERRKTRHFLDYLQEFLGVMSTEWAMEV
uniprot
proteins
function
FUNCTION: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:10446387). Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity). {ECO:0000250|UniProtKB:P04401, ECO:0000250|UniProtKB:P05113, ECO:0000269|PubMed:10446387}.
uniprot
proteins
mass_dalton
15207
uniprot
proteins
protein_family
IL-5 family
uniprot
proteins
pubmed
10446387
uniprot
proteins
pubmed
1653053
uniprot
proteins
sequence_length
132
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins