LY96
entrez
23643
canonical
uniprot
Q9Y6Y9
canonical
ensembl
ENSG00000154589
resolver
ensp
ENSP00000284818
resolver
ensp
ENSP00000430533
resolver
ensp
ENSP00000774065
resolver
ensp
ENSP00000791428
resolver
genesymbol
LY96
resolver
genesymbol_syn
ESOP1
resolver
genesymbol_syn
MD2
resolver
hgnc
HGNC:17156
resolver
uniprot
B3Y6A5
resolver
uniprot
E5RJJ7
resolver
uniprot_entry
LY96_HUMAN
resolver
uniprot_sec
B3Y6A5
resolver
uniprot_sec
E5RJJ7
resolver
amino_acid_sequence
MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKRSKGLLHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFSFKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN
uniprot
proteins
function
FUNCTION: Binds bacterial lipopolysaccharide (LPS) (PubMed:17569869, PubMed:17803912). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581). {ECO:0000269|PubMed:10359581, ECO:0000269|PubMed:11160242, ECO:0000269|PubMed:11593030, ECO:0000269|PubMed:17569869, ECO:0000269|PubMed:17803912}.
uniprot
proteins
mass_dalton
18546
uniprot
proteins
mutagenesis
MUTAGEN 95; /note="C->Y: Abolishes LPS-response."; /evidence="ECO:0000269|PubMed:11435474
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; high-mannose. {ECO:0000269|PubMed:11593030, ECO:0000269|PubMed:17569869}.
uniprot
proteins
pubmed
10359581
uniprot
proteins
pubmed
10891475
uniprot
proteins
pubmed
11160242
uniprot
proteins
pubmed
11274165
uniprot
proteins
pubmed
11435474
uniprot
proteins
pubmed
11593030
uniprot
proteins
pubmed
12642668
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17569869
uniprot
proteins
pubmed
17803912
uniprot
proteins
pubmed
18810425
uniprot
proteins
sequence_length
160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:10359581, ECO:0000269|PubMed:11593030, ECO:0000305|PubMed:11274165}. Secreted {ECO:0000269|PubMed:11593030}. Note=Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581). {ECO:0000269|PubMed:10359581, ECO:0000269|PubMed:11593030}.
uniprot
proteins