TJP2
entrez
9414
canonical
uniprot
Q9UDY2
canonical
ensembl
ENSG00000119139
resolver
ensp
ENSP00000345893
resolver
ensp
ENSP00000366453
resolver
ensp
ENSP00000438262
resolver
ensp
ENSP00000442090
resolver
ensp
ENSP00000489860
resolver
ensp
ENSP00000496877
resolver
ensp
ENSP00000497861
resolver
ensp
ENSP00000498068
resolver
ensp
ENSP00000566782
resolver
enst
ENST00000649134
resolver
genesymbol
TJP2
resolver
genesymbol_syn
X104
resolver
genesymbol_syn
ZO2
resolver
hgnc
HGNC:11828
resolver
uniprot
A0A3B3IU51
resolver
uniprot
A2A3H9
resolver
uniprot
B7Z2R3
resolver
uniprot
B7Z2R8
resolver
uniprot
B7Z7T6
resolver
uniprot
B7Z954
resolver
uniprot
F5H301
resolver
uniprot
F5H886
resolver
uniprot
Q15883
resolver
uniprot
Q5VXL0
resolver
uniprot
Q5VXL1
resolver
uniprot
Q8N756
resolver
uniprot
Q8NI14
resolver
uniprot
Q99839
resolver
uniprot
Q9UDY0
resolver
uniprot
Q9UDY1
resolver
uniprot_entry
A0A3B3IU51_HUMAN
resolver
uniprot_entry
B7Z2R3_HUMAN
resolver
uniprot_entry
B7Z954_HUMAN
resolver
uniprot_entry
ZO2_HUMAN
resolver
uniprot_sec
A2A3H9
resolver
uniprot_sec
B7Z2R8
resolver
uniprot_sec
B7Z7T6
resolver
uniprot_sec
F5H301
resolver
uniprot_sec
F5H886
resolver
uniprot_sec
Q15883
resolver
uniprot_sec
Q5VXL0
resolver
uniprot_sec
Q5VXL1
resolver
uniprot_sec
Q8N756
resolver
uniprot_sec
Q8NI14
resolver
uniprot_sec
Q99839
resolver
uniprot_sec
Q9UDY0
resolver
uniprot_sec
Q9UDY1
resolver
amino_acid_sequence
MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPSAVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLGKVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
uniprot
proteins
disease_involvement
DISEASE: Hypercholanemia, familial, 1 (FHCA1) [MIM:607748]: A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. {ECO:0000269|PubMed:12704386}. Note=The disease may be caused by variants affecting distinct genetic loci, including the gene represented in this entry.; DISEASE: Cholestasis, progressive familial intrahepatic, 4 (PFIC4) [MIM:615878]: A disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood. PFIC4 inheritance is autosomal recessive. {ECO:0000269|PubMed:24614073}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}.
uniprot
proteins
mass_dalton
133958
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
10360833
uniprot
proteins
pubmed
10495427
uniprot
proteins
pubmed
11018256
uniprot
proteins
pubmed
12704386
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15975580
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17897942
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18823282
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24614073
uniprot
proteins
pubmed
7951235
uniprot
proteins
sequence_length
1190
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9Z0U1}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9Z0U1}. Nucleus {ECO:0000250}. Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures. Localizes to tight junctions during initial stages of their formation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q95168}.
uniprot
proteins