MAX
entrez
4149
canonical
uniprot
P61244
canonical
ensembl
ENSG00000125952
resolver
ensp
ENSP00000246163
resolver
ensp
ENSP00000342482
resolver
ensp
ENSP00000351175
resolver
ensp
ENSP00000351490
resolver
ensp
ENSP00000450955
resolver
ensp
ENSP00000451907
resolver
ensp
ENSP00000452197
resolver
ensp
ENSP00000452286
resolver
ensp
ENSP00000452405
resolver
ensp
ENSP00000678335
resolver
ensp
ENSP00000678337
resolver
ensp
ENSP00000678339
resolver
ensp
ENSP00000678341
resolver
ensp
ENSP00000678344
resolver
ensp
ENSP00000678347
resolver
enst
ENST00000555419
resolver
enst
ENST00000555667
resolver
enst
ENST00000557277
resolver
enst
ENST00000557746
resolver
genesymbol
MAX
resolver
genesymbol_syn
BHLHD4
resolver
hgnc
HGNC:6913
resolver
uniprot
A6NH73
resolver
uniprot
A8K265
resolver
uniprot
A8K4G4
resolver
uniprot
A8K824
resolver
uniprot
G3V302
resolver
uniprot
G3V563
resolver
uniprot
G3V5C3
resolver
uniprot
G3V5L1
resolver
uniprot
P25912
resolver
uniprot
P52163
resolver
uniprot
Q14803
resolver
uniprot
Q6V3B1
resolver
uniprot
Q8TAX8
resolver
uniprot
Q96CY8
resolver
uniprot_entry
G3V302_HUMAN
resolver
uniprot_entry
G3V563_HUMAN
resolver
uniprot_entry
G3V5C3_HUMAN
resolver
uniprot_entry
G3V5L1_HUMAN
resolver
uniprot_entry
MAX_HUMAN
resolver
uniprot_entry
Q6V3B1_HUMAN
resolver
uniprot_entry
Q8TAX8_HUMAN
resolver
uniprot_sec
A6NH73
resolver
uniprot_sec
A8K265
resolver
uniprot_sec
A8K4G4
resolver
uniprot_sec
A8K824
resolver
uniprot_sec
P25912
resolver
uniprot_sec
P52163
resolver
uniprot_sec
Q14803
resolver
uniprot_sec
Q96CY8
resolver
amino_acid_sequence
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDNSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS
uniprot
proteins
disease_involvement
DISEASE: Pheochromocytoma (PCC) [MIM:171300]: A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. {ECO:0000269|PubMed:21685915, ECO:0000269|PubMed:22452945, ECO:0000269|PubMed:26070438}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Polydactyly-macrocephaly syndrome (PDMCS) [MIM:620712]: An autosomal dominant syndrome characterized by progressive macrocephaly and post-axial polydactyly, a condition defined by the occurrence of supernumerary digits affecting the fifth finger and/or toe. Additional variable features include ocular anomalies, global developmental delay and autistic traits. {ECO:0000269|PubMed:38141607}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. {ECO:0000269|PubMed:26070438}.
uniprot
proteins
mass_dalton
18275
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="K->Q: Kept nuclear localization. Loss of nuclear localization; when associated with Q-153 and Q-154."; /evidence="ECO:0000269|PubMed:17217336"; MUTAGEN 66; /note="K->R: Loss of acetylation, kept nuclear localization; when associated with R-153 and R-154."; /evidence="ECO:0000269|PubMed:17217336"; MUTAGEN 153; /note="K->Q: Loss of nuclear localization; when associated with Q-66 and Q-154. Kept nuclear localization; when associated with Q-154."; /evidence="ECO:0000269|PubMed:17217336"; MUTAGEN 153; /note="K->R: Loss of acetylation, kept nuclear localization; when associated with R-66 and R-154."; /evidence="ECO:0000269|PubMed:17217336"; MUTAGEN 154; /note="K->Q: Loss of nuclear localization; when associated with Q-66 and Q-153. Kept nuclear localization; when associated with Q-153."; /evidence="ECO:0000269|PubMed:17217336"; MUTAGEN 154; /note="K->R: Loss of acetylation, kept nuclear localization; when associated with R-66 and R-153."; /evidence="ECO:0000269|PubMed:17217336
uniprot
proteins
post_translational_modification
PTM: Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes. {ECO:0000269|PubMed:17217336}.
uniprot
proteins
protein_family
MAX family
uniprot
proteins
pubmed
12004135
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
1566084
uniprot
proteins
pubmed
15960975
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17217336
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
2006410
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21685915
uniprot
proteins
pubmed
22452945
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26070438
uniprot
proteins
pubmed
38141607
uniprot
proteins
pubmed
8426752
uniprot
proteins
pubmed
8479534
uniprot
proteins
pubmed
9115440
uniprot
proteins
sequence_length
160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cell projection, dendrite {ECO:0000250}.
uniprot
proteins