TFDP1
entrez
7027
canonical
uniprot
Q14186
canonical
ensembl
ENSG00000198176
resolver
ensp
ENSP00000364519
resolver
ensp
ENSP00000536300
resolver
ensp
ENSP00000536301
resolver
ensp
ENSP00000536303
resolver
ensp
ENSP00000536306
resolver
ensp
ENSP00000536311
resolver
ensp
ENSP00000597766
resolver
ensp
ENSP00000597769
resolver
ensp
ENSP00000597770
resolver
ensp
ENSP00000597774
resolver
ensp
ENSP00000630116
resolver
ensp
ENSP00000630119
resolver
ensp
ENSP00000630125
resolver
ensp
ENSP00000786569
resolver
ensp
ENSP00000786571
resolver
ensp
ENSP00000794081
resolver
genesymbol
TFDP1
resolver
genesymbol_syn
DP1
resolver
hgnc
HGNC:11749
resolver
uniprot
B4DLQ9
resolver
uniprot
Q5JSB4
resolver
uniprot
Q8IZL5
resolver
uniprot_entry
TFDP1_HUMAN
resolver
uniprot_sec
B4DLQ9
resolver
uniprot_sec
Q5JSB4
resolver
uniprot_sec
Q8IZL5
resolver
amino_acid_sequence
MAKDAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVIGTPQRPAASNTLVVGSPHTPSTHFASQNQPSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRHAEQQASRPPPPNSVIHLPFIIVNTSKKTVIDCSISNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKMARSLVPKALEPYVTEMAQGTVGGVFITTAGSTSNGTRFSASDLTNGADGMLATSSNGSQYSGSRVETPVSYVGEDDEEDDDFNENDEDD
uniprot
proteins
function
FUNCTION: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:7739537, PubMed:8405995). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:7739537, ECO:0000269|PubMed:8405995}.
uniprot
proteins
mass_dalton
45070
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation. {ECO:0000269|PubMed:8039504}.; PTM: Ubiquitinated by the BCR(KBTBD5) complex, leading to its subsequent degradation. {ECO:0000250|UniProtKB:Q08639}.
uniprot
proteins
protein_family
E2F/DP family
uniprot
proteins
pubmed
12004135
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17531812
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20176812
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
7739537
uniprot
proteins
pubmed
8039504
uniprot
proteins
pubmed
8405995
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q08639}. Cytoplasm {ECO:0000250|UniProtKB:Q08639}. Note=Shuttles between the cytoplasm and nucleus and translocates into the nuclear compartment upon heterodimerization with E2F1. {ECO:0000250|UniProtKB:Q08639}.
uniprot
proteins