Ptk7
entrez
71461
canonical
uniprot
Q8BKG3
canonical
ensembl
ENSMUSG00000023972
resolver
ensp
ENSMUSP00000043703
resolver
enst
ENSMUST00000044442
resolver
genesymbol
Ptk7
resolver
uniprot
Q3V422
resolver
uniprot
Q6W8S9
resolver
uniprot
Q8CHK5
resolver
uniprot
Q8K178
resolver
uniprot_entry
PTK7_MOUSE
resolver
uniprot_sec
Q3V422
resolver
uniprot_sec
Q6W8S9
resolver
uniprot_sec
Q8CHK5
resolver
uniprot_sec
Q8K178
resolver
amino_acid_sequence
MGARPLTLLRALLLPLLAGAQAAIVFIKEPSSQDALQGRRALLRCEVEAPDPVHVYWLLNGVPVQDTERRFAQGSSLSFAAVDRLQDSGAFQCVARDNVTGEEVRSTNASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDDQSTHTVSSRERNLTLRPASPEHSGLYSCCAHNAFGQACSSQNFTLSVADESFARVVLAPQDVVVARNEEAMFHCQFSAQPPPSLQWVFEDETPITNRSRPPHLRRAVVFANGSLLLTQVRPRNAGVYRCIGQGQRGPPIVLEATLHLAEIEDMLPFEPRVFIAGDEERVTCPAPQGLPTPSVWWEHAGVPLPAHGRVHQKGLELVFVTIAESDTGVYTCHASNLAGQRRQDVNITVATVPTWLRKPQDSQLEEGKPGYLHCLTQATPKPTVIWYRNQMLISEDSRFEVSKNGTLRINSVEVYDGTLYRCVSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTVKWVRADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNEPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLRCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGSYTCIAGNSCNIRHTEAPLLVVDKPVMEDSEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPPATNKRHSAGDRMHFPRASLQPITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSLQSRDEQQQLDFRREVEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKNKDEKLKSQPLSTKQKVALCSQVALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAVLEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAPNPKDRPSFSEIASTLGDSPADSKQ
uniprot
proteins
function
FUNCTION: Inactive tyrosine kinase involved in the Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathways. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. Does not bind ATP (By similarity). {ECO:0000250|UniProtKB:Q13308, ECO:0000269|PubMed:15229603, ECO:0000269|PubMed:19439496, ECO:0000269|PubMed:20704721}.
uniprot
proteins
mass_dalton
117532
uniprot
proteins
post_translational_modification
PTM: MMP14 cleaves PTK7 between Pro-613 and Leu-614 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway. {ECO:0000250|UniProtKB:Q13308}.
uniprot
proteins
protein_family
Insulin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
15019986
uniprot
proteins
pubmed
15229603
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19439496
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
20704721
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1062
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13308}; Single-pass type I membrane protein {ECO:0000255}. Cell junction {ECO:0000250|UniProtKB:Q13308}. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells. {ECO:0000250|UniProtKB:Q13308}.
uniprot
proteins
transmembrane_region
TRANSMEM 697..717; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins