Nr2f6
entrez
13864
canonical
uniprot
P43136
canonical
ensembl
ENSMUSG00000002393
resolver
ensp
ENSMUSP00000002466
resolver
enst
ENSMUST00000002466
resolver
genesymbol
Nr2f6
resolver
genesymbol_syn
Ear-2
resolver
genesymbol_syn
Ear2
resolver
genesymbol_syn
Erbal2
resolver
uniprot
Q61504
resolver
uniprot
Q922G8
resolver
uniprot_entry
NR2F6_MOUSE
resolver
uniprot_sec
Q61504
resolver
uniprot_sec
Q922G8
resolver
amino_acid_sequence
MAMVTGGWGDPGGDTNGVDKAGGSYPRATEDDSASPPGATSDAEPGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHALPGPAACSPPGATGVEPFTGPPVSELIAQLLRAEPYPAAGRFGGGGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPAADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDAAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYGSG
uniprot
proteins
function
FUNCTION: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). {ECO:0000269|PubMed:12690040, ECO:0000269|PubMed:15741322, ECO:0000269|PubMed:18701084}.
uniprot
proteins
mass_dalton
41968
uniprot
proteins
protein_family
NR2 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10318855
uniprot
proteins
pubmed
11382775
uniprot
proteins
pubmed
12690040
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15741322
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18701084
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7947324
uniprot
proteins
pubmed
8194772
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:12690040}.
uniprot
proteins