Slc5a1
entrez
25552
canonical
uniprot
P53790
canonical
ensembl
ENSRNOG00000017775
resolver
ensp
ENSRNOP00000024165
resolver
enst
ENSRNOT00000024165
resolver
genesymbol
Slc5a1
resolver
genesymbol_syn
Sglt1
resolver
uniprot
P97787
resolver
uniprot_entry
SC5A1_RAT
resolver
uniprot_sec
P97787
resolver
activity_regulation
ACTIVITY REGULATION: Enhanced by the interaction with PDZK1IP1/MAP17; but unlike SLC5A2/SGLT2, PDZK1IP1 is not essential for SLC5A1 transporter activity (By similarity). Possibly modulated by cholesterol binding (By similarity). {ECO:0000250|UniProtKB:P13866}.
uniprot
proteins
amino_acid_sequence
MDSSTLSPAVTATDAPIQSYERIRNAADISVIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAAAGIAMGGFEWNALVFVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGKRIQIYLSVLSLLLYIFTKISADIFSGAIFINLALGLDIYLAIFILLAITALYTITGGLAAVIYTDTLQTAIMLVGSFILTGFAFREVGGYEAFMDKYMKAIPTLVSDGNITVKEECYTPRADSFHIFRDPITGDMPWPGLIFGLSILALWYWCTDQVIVQRCLSAKNMSHVKAGCTLCGYLKLLPMFLMVMPGMISRILYTDKIACVLPSECKKYCGTPVGCTNIAYPTLVVELMPNGLRGLMLSVMMASLMSSLTSIFNSASTLFTMDIYTKIRKGASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLILGFLIGISRMITEFAYGTGSCMEPSNCPKIICGVHYLYFAIILFAISVVTVLVISLLTKPIPDVHLYRLCWSLRNSTEERIDLDAGEEEPVEEDPKDTIEIDAEAPQKEKGCFRKAYDLFCGLDQDKGPKMTKEEEEAMKLKMTDTSEKPLWRTVVNINGIILLAVAVFCHAYFA
uniprot
proteins
function
FUNCTION: Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (By similarity). Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (By similarity). Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules (By similarity). Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception (By similarity). Acts as a water channel enabling passive water transport in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity comparable to aquaporins and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine. {ECO:0000250|UniProtKB:P13866, ECO:0000250|UniProtKB:Q8C3K6}.
uniprot
proteins
mass_dalton
73066
uniprot
proteins
post_translational_modification
PTM: N-glycosylation is not necessary for the cotransporter function. {ECO:0000250|UniProtKB:P13866}.
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8163506
uniprot
proteins
pubmed
9214758
uniprot
proteins
sequence_length
665
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q8C3K6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P13866}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..47; /note="Helical; Name=TM0"; /evidence="ECO:0000250|UniProtKB:P13866"; TRANSMEM 67..90; /note="Helical; Name=TM1"; /evidence="ECO:0000250|UniProtKB:P13866"; TRANSMEM 96..117; /note="Helical; Name=TM2"; /evidence="ECO:0000250|UniProtKB:P13866"; TRANSMEM 140..169; /note="Helical; Name=TM3"; /evidence="ECO:0000250|UniProtKB:P13866"; TRANSMEM 177..193; /note="Helical; Name=TM4"; /evidence="ECO:0000250|UniProtKB:P13866"; TRANSMEM 203..221; /note="Helical; Name=TM5"; /evidence="ECO:0000250|UniProtKB:P13866"; TRANSMEM 276..295; /note="Helical; Name=TM6"; /evidence="ECO:0000250|UniProtKB:P13866"; TRANSMEM 310..331; /note="Helical; Name=TM7"; /evidence="ECO:0000250|UniProtKB:P13866"; TRANSMEM 376..406; /note="Helical; Name=TM8"; /evidence="ECO:0000250|UniProtKB:P13866"; TRANSMEM 423..444; /note="Helical; Name=TM9"; /evidence="ECO:0000250|UniProtKB:P13866"; TRANSMEM 452..477; /note="Helical; Name=TM10"; /evidence="ECO:0000250|UniProtKB:P13866"; TRANSMEM 482..504; /note="Helical; Name=TM11"; /evidence="ECO:0000250|UniProtKB:P13866"; TRANSMEM 526..547; /note="Helical; Name=TM12"; /evidence="ECO:0000250|UniProtKB:P13866"; TRANSMEM 646..663; /note="Helical; Name=TM13"; /evidence="ECO:0000250|UniProtKB:P13866
uniprot
proteins