HAVCR1
entrez
26762
canonical
uniprot
Q96D42
canonical
ensembl
ENSG00000113249
resolver
ensp
ENSP00000344844
resolver
ensp
ENSP00000427898
resolver
ensp
ENSP00000428524
resolver
ensp
ENSP00000514125
resolver
ensp
ENSP00000623732
resolver
ensp
ENSP00000623733
resolver
ensp
ENSP00000762335
resolver
ensp
ENSP00000762338
resolver
enst
ENST00000339252
resolver
enst
ENST00000522693
resolver
enst
ENST00000523175
resolver
enst
ENST00000953673
resolver
enst
ENST00000953674
resolver
genesymbol
HAVCR1
resolver
genesymbol_syn
KIM1
resolver
genesymbol_syn
TIM1
resolver
genesymbol_syn
TIMD1
resolver
hgnc
HGNC:17866
resolver
uniprot
B4DPB1
resolver
uniprot
E9PFX0
resolver
uniprot
F1CME7
resolver
uniprot
O43656
resolver
uniprot_entry
B4DPB1_HUMAN
resolver
uniprot_entry
E9PFX0_HUMAN
resolver
uniprot_entry
F1CME7_HUMAN
resolver
uniprot_entry
HAVR1_HUMAN
resolver
uniprot_sec
O43656
resolver
amino_acid_sequence
MHPQVVILSLILHLADSVAGSVKVGGEAGPSVTLPCHYSGAVTSMCWNRGSCSLFTCQNGIVWTNGTHVTYRKDTRYKLLGDLSRRDVSLTIENTAVSDSGVYCCRVEHRGWFNDMKITVSLEIVPPKVTTTPIVTTVPTVTTVRTSTTVPTTTTVPMTTVPTTTVPTTMSIPTTTTVLTTMTVSTTTSVPTTTSIPTTTSVPVTTTVSTFVPPMPLPRQNHEPVATSPSSPQPAETHPTTLQGAIRREPTSSPLYSYTTDGNDTVTESSDGLWNNNQTQLFLEHSLLTANTTKGIYAGVCISVLVLLALLGVIIAKKYFFKKEVQQLSVSFSSLQIKALQNAVEKEVQAEDNIYIENSLYATD
uniprot
proteins
function
FUNCTION: Phosphatidylserine receptor that plays an important functional role in regulatory B-cell homeostasis including generation, expansion and suppressor functions (PubMed:18082433, PubMed:18414680). Involved in efferocytosis, the process by which apoptotic cells are removed, by binding to phosphatidylserine present on apoptotic cells and promoting their engulfment (PubMed:18082433). Confers phagocytic ability on injured kidney epithelial cells, allowing them to bind to and internalize apoptotic bodies and necrotic debris following kidney injury (PubMed:17471468, PubMed:18414680). The ectodomain binds to the surface of apoptotic kidney epithelial cells via phosphatidylserine and oxidized phospholipids exposed on the cell membrane of the apoptotic cells (PubMed:18414680). HAVCR1-expressing cells are also capable of phagocytosing Gram-negative and Gram-positive bacteria (PubMed:18414680). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (PubMed:24703780). Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (PubMed:24703780). Acts as a regulator of T-cell proliferation (By similarity). Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity). {ECO:0000250|UniProtKB:Q5QNS5, ECO:0000269|PubMed:17471468, ECO:0000269|PubMed:18082433, ECO:0000269|PubMed:18414680, ECO:0000269|PubMed:24703780}.; FUNCTION: (Microbial infection) Acts as a receptor for Hepatitis A virus. {ECO:0000269|PubMed:29437974, ECO:0000269|PubMed:9658108}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871). Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP (PubMed:26487564). {ECO:0000269|PubMed:21536871, ECO:0000269|PubMed:26487564}.; FUNCTION: (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:23084921). TIM1 and Dengue virus are co-internalized during virus entry (PubMed:29742433). {ECO:0000269|PubMed:23084921, ECO:0000269|PubMed:29742433}.; FUNCTION: (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E. {ECO:0000269|PubMed:32641828}.; FUNCTION: (Microbial infection) Plays a positive role in Chikungunya virus cell entry. {ECO:0000269|PubMed:34359995}.
uniprot
proteins
mass_dalton
39250
uniprot
proteins
mutagenesis
MUTAGEN 114; /note="N->A: About 60% loss of Chikungunya virus entry."; /evidence="ECO:0000269|PubMed:34359995"; MUTAGEN 115; /note="D->A: About 25% loss of Chikungunya virus entry."; /evidence="ECO:0000269|PubMed:34359995"; MUTAGEN 338; /note="K->R: About 50% loss of ubiquitination."; /evidence="ECO:0000269|PubMed:29742433"; MUTAGEN 338; /note="K->R: Complete loss of ubiquitination; when associated with R-346."; /evidence="ECO:0000269|PubMed:29742433"; MUTAGEN 346; /note="K->R: About 50% loss of ubiquitination."; /evidence="ECO:0000269|PubMed:29742433"; MUTAGEN 346; /note="K->R: Complete loss of ubiquitination; when associated with R-338."; /evidence="ECO:0000269|PubMed:29742433
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated at two lysine residues Lys-338 and Lys-346 on its cytoplasmic domain. Ubiquitination promotes receptor endocytosis and target receptors for lysosomal degradation and termination of receptor signaling. {ECO:0000269|PubMed:29742433}.; PTM: (Microbial infection) Ubiquitination is required for Dengue virus endocytosis. {ECO:0000269|PubMed:29742433}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
TIM family
uniprot
proteins
pubmed
14534576
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17229699
uniprot
proteins
pubmed
17471468
uniprot
proteins
pubmed
18082433
uniprot
proteins
pubmed
18414680
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21536871
uniprot
proteins
pubmed
23084921
uniprot
proteins
pubmed
24703780
uniprot
proteins
pubmed
26487564
uniprot
proteins
pubmed
26726878
uniprot
proteins
pubmed
29437974
uniprot
proteins
pubmed
29742433
uniprot
proteins
pubmed
32641828
uniprot
proteins
pubmed
34359995
uniprot
proteins
pubmed
9658108
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29742433}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, phagocytic cup {ECO:0000269|PubMed:18414680}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:18414680}.
uniprot
proteins
transmembrane_region
TRANSMEM 296..316; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins