Trim39
entrez
79263
canonical
uniprot
Q9ESN2
canonical
ensembl
ENSMUSG00000045409
resolver
ensp
ENSMUSP00000039790
resolver
ensp
ENSMUSP00000109336
resolver
ensp
ENSMUSP00000133298
resolver
ensp
ENSMUSP00000206513
resolver
ensp
ENSMUSP00000206519
resolver
enst
ENSMUST00000042717
resolver
enst
ENSMUST00000113706
resolver
enst
ENSMUST00000173369
resolver
genesymbol
Trim39
resolver
genesymbol_syn
Rnf23
resolver
genesymbol_syn
Tfp
resolver
genesymbol_syn
mKIAA4179
resolver
uniprot
E9QLN4
resolver
uniprot
G3UWI0
resolver
uniprot
Q570Z1
resolver
uniprot
Q8BPR5
resolver
uniprot
Q8K0F7
resolver
uniprot_entry
E9QLN4_MOUSE
resolver
uniprot_entry
G3UWI0_MOUSE
resolver
uniprot_entry
Q570Z1_MOUSE
resolver
uniprot_entry
TRI39_MOUSE
resolver
uniprot_sec
Q8BPR5
resolver
uniprot_sec
Q8K0F7
resolver
amino_acid_sequence
MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQTVKRKIRDESLCSQHHEPLSLFCYEDQEAVCLICAISHTHRPHTVVPMDDATQEYKEKLQKCLEPLEQKLQEITCCKASEEKKPGELKRLVESRRQQILKEFEELHRRLDEEQQTLLSRLEEEEQDILQRLRENAAHLGDRRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPQRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase (By similarity). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similarity). {ECO:0000250|UniProtKB:Q9HCM9}.
uniprot
proteins
mass_dalton
56369
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000250|UniProtKB:Q9HCM9}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11006080
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9HCM9}. Mitochondrion {ECO:0000250|UniProtKB:Q9HCM9}. Nucleus {ECO:0000250|UniProtKB:Q9HCM9}. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus. {ECO:0000250|UniProtKB:Q9HCM9}.
uniprot
proteins