Arb2a
entrez
68675
canonical
uniprot
Q3TNH5
canonical
ensembl
ENSMUSG00000064138
resolver
ensp
ENSMUSP00000089038
resolver
ensp
ENSMUSP00000096960
resolver
ensp
ENSMUSP00000133140
resolver
ensp
ENSMUSP00000233024
resolver
ensp
ENSMUSP00000233026
resolver
ensp
ENSMUSP00000233037
resolver
ensp
ENSMUSP00000233038
resolver
enst
ENSMUST00000091459
resolver
genesymbol
Arb2a
resolver
genesymbol_syn
1110033M05Rik
resolver
genesymbol_syn
Fam172a
resolver
uniprot
E9QMA2
resolver
uniprot
Q3TLW0
resolver
uniprot
Q6PFX1
resolver
uniprot_entry
ARB2A_MOUSE
resolver
uniprot_entry
E9QMA2_MOUSE
resolver
uniprot_entry
Q6PFX1_MOUSE
resolver
uniprot_sec
Q3TLW0
resolver
amino_acid_sequence
MSISLSSLIFLPIWINMAQMQQGGSNETEQTAALKDLLSRIDLDELMKKDEPPFDFPDTLEGFEYAFNEKGQLRHIKTGEPFVFNYREDLHRWNQKRYEALGEIITRYVYELLESDCNLKKISIPVDATESEPKSFIFMSEDALTNPQKLMVLIHGSGVVRAGQWARRLIINEDLDSGTQIPFIKRAMDEGYGVIVLNPNENYIEVEKQKMHKQSSSSDGTDEPAGKRERRDKVSKETKKRRDFYEKYRNPQKEKEMMQLFIRENGSPEEHAVYVWDHFIAQAAAENVFFVAHSYGGLAFVELMIQREADVKSKVTAVALTDSVHNVWHQEAGKTIREWMRENCCNWVSSSEPLDTSVESMLPDCPRVSAGTDRHELTSWKSFPSIFKFFAEASEAKSSSQKPALTRRSHRIKHEEL
uniprot
proteins
function
FUNCTION: Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface (PubMed:29311329). May have hydrolase activity (PubMed:29311329). {ECO:0000269|PubMed:29311329}.
uniprot
proteins
mass_dalton
48072
uniprot
proteins
mutagenesis
MUTAGEN 229; /note="E->Q: Fails to interact with AGO2. Decreases nuclear localization."; /evidence="ECO:0000269|PubMed:29311329"; MUTAGEN 294; /note="S->A: Loss of nucleophilicity of Ser-294."; /evidence="ECO:0000269|PubMed:29311329"; MUTAGEN 307..417; /note="Missing: Fails to interact with AGO2."; /evidence="ECO:0000269|PubMed:29311329
uniprot
proteins
protein_family
ARB2A family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29311329
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29311329}. Cytoplasm {ECO:0000269|PubMed:29311329}. Endoplasmic reticulum {ECO:0000269|PubMed:29311329}.
uniprot
proteins