REC8
entrez
9985
canonical
uniprot
O95072
canonical
ensembl
ENSG00000100918
resolver
ensembl
ENSG00000285007
resolver
ensp
ENSP00000452701
resolver
ensp
ENSP00000482439
resolver
ensp
ENSP00000482546
resolver
ensp
ENSP00000754072
resolver
genesymbol
REC8
resolver
genesymbol_syn
REC8L1
resolver
hgnc
HGNC:16879
resolver
uniprot
A8K576
resolver
uniprot
D3DS62
resolver
uniprot
Q658V5
resolver
uniprot
Q6IA92
resolver
uniprot
Q8WUV8
resolver
uniprot
Q9BTF2
resolver
uniprot
Q9NVQ9
resolver
uniprot_entry
REC8_HUMAN
resolver
uniprot_sec
A8K576
resolver
uniprot_sec
D3DS62
resolver
uniprot_sec
Q658V5
resolver
uniprot_sec
Q6IA92
resolver
uniprot_sec
Q8WUV8
resolver
uniprot_sec
Q9BTF2
resolver
uniprot_sec
Q9NVQ9
resolver
amino_acid_sequence
MFYYPNVLQRHTGCFATIWLAATRGSRLVKREYLRVNVVKTCEEILNYVLVRVQPPQPGLPRPRFSLYLSAQLQIGVIRVYSQQCQYLVEDIQHILERLHRAQLQIRIDMETELPSLLLPNHLAMMETLEDAPDPFFGMMSVDPRLPSPFDIPQIRHLLEAAIPERVEEIPPEVPTEPREPERIPVTVLPPEAITILEAEPIRMLEIEGERELPEVSRRELDLLIAEEEEAILLEIPRLPPPAPAEVEGIGEALGPEELRLTGWEPGALLMEVTPPEELRLPAPPSPERRPPVPPPPRRRRRRRLLFWDKETQISPEKFQEQLQTRAHCWECPMVQPPERTIRGPAELFRTPTLSGWLPPELLGLWTHCAQPPPKALRRELPEEAAAEEERRKIEVPSEIEVPREALEPSVPLMVSLEISLEAAEEEKSRISLIPPEERWAWPEVEAPEAPALPVVPELPEVPMEMPLVLPPELELLSLEAVHRAVALELQANREPDFSSLVSPLSPRRMAARVFYLLLVLSAQQILHVKQEKPYGRLLIQPGPRFH
uniprot
proteins
function
FUNCTION: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
62614
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
Rad21 family
uniprot
proteins
pubmed
10207075
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6AYJ4}. Chromosome {ECO:0000250|UniProtKB:Q6AYJ4}. Chromosome, centromere {ECO:0000250|UniProtKB:Q6AYJ4}. Note=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II. Localized to centromeres and spindle poles in endopolyploid tumor cells. {ECO:0000250|UniProtKB:Q6AYJ4}.
uniprot
proteins