Dap
entrez
223453
canonical
uniprot
Q91XC8
canonical
ensembl
ENSMUSG00000039168
resolver
ensp
ENSMUSP00000047186
resolver
enst
ENSMUST00000044524
resolver
genesymbol
Dap
resolver
uniprot
Q3U706
resolver
uniprot_entry
DAP1_MOUSE
resolver
uniprot_entry
Q3U706_MOUSE
resolver
amino_acid_sequence
MSSPPEGKLETKAGHPPAVKAGGMRIVQKHPHTGDGKEERDKDDQEWESTSPPKPTVFISGVIARGDKDFPPAAAQVAHQKPHASMDKHVSPRTQHIQQPRK
uniprot
proteins
function
FUNCTION: Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation. Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation. Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation. Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity). {ECO:0000250|UniProtKB:P51397, ECO:0000250|UniProtKB:Q9I9N1}.
uniprot
proteins
mass_dalton
11155
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy. {ECO:0000250|UniProtKB:P51397}.
uniprot
proteins
protein_family
DAP-DAPL1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
102
uniprot
proteins