Capzb
entrez
12345
canonical
uniprot
P47757
canonical
ensembl
ENSMUSG00000028745
resolver
ensp
ENSMUSP00000030518
resolver
ensp
ENSMUSP00000099565
resolver
ensp
ENSMUSP00000099566
resolver
genesymbol
Capzb
resolver
genesymbol_syn
Cappb1
resolver
uniprot
A2AMV7
resolver
uniprot
Q923G3
resolver
uniprot_entry
CAPZB_MOUSE
resolver
uniprot_entry
Q923G3_MOUSE
resolver
uniprot_sec
A2AMV7
resolver
amino_acid_sequence
MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSLDAIPDNHKFKQLQRELSQVLTQRQVYIQPDN
uniprot
proteins
function
FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000250|UniProtKB:P47756}.
uniprot
proteins
mass_dalton
31345
uniprot
proteins
protein_family
F-actin-capping protein beta subunit family
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19341723
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7929588
uniprot
proteins
sequence_length
277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A9XFX6}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Cytoplasm, myofibril, sarcomere {ECO:0000250}. Note=In cardiac muscle, isoform 1 is located at Z-disks of sarcomeres while isoform 2 is enriched at intercalated disks. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytoskeleton, perinuclear theca, calyx {ECO:0000250|UniProtKB:P79136}. Note=Isoform 3 is located to sperm head cytoskeletal structure tightly associated to the nucleus (By similarity). Isoform 3 colocalizes with the alpha subunit in testicular sperm and to the acrosome in elongating and condensing spermatids. {ECO:0000250|UniProtKB:P79136}.
uniprot
proteins