Clcnkb
entrez
79430
canonical
uniprot
P51802
canonical
ensembl
ENSRNOG00000009897
resolver
ensp
ENSRNOP00000049598
resolver
ensp
ENSRNOP00000082436
resolver
enst
ENSRNOT00000050729
resolver
enst
ENSRNOT00000101714
resolver
genesymbol
Clcnkb
resolver
uniprot
A0A8I5ZU48
resolver
uniprot
E9PTA8
resolver
uniprot_entry
A0A8I5ZU48_RAT
resolver
uniprot_entry
CLCKB_RAT
resolver
uniprot_entry
E9PTA8_RAT
resolver
amino_acid_sequence
MEEIVGLREGSPRKPVPLQELWRPCPRIRRNIQGSLEWLKERLFRVGEDWYFLVALGVLMALISYAMNFAIGRVVRAHKWLYREIGDGHLLRYLSWTVYPVALLSFSSGFSQSITPSSGGSGIPEVKTILTGVILEDYLDIKNFGAKVVGLSCTLATGSTIFLGKLGPFVHLSVMIAAYLGRVRTKTVGEPENKTKEMELLAAGAAVGVATVFAAPISGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFHLLAVFNSEQETITSIYKTSFPVDIPFDLPEIFFFVALGAICGILSCGYNYCQRTSLFFLKSNGFTSKLLATSKPLYSALAAVVLASITYPPGVGRFMASRLSMSEYLETLFDNNSWALMTKNSSPPWSAEPDPQNLWLEWCHPQMTVFGTLVFFLVMKFWMLILATTIPIPAGYFLPIFVYGAAIGRLFGEVLSLAFPEGIVAGGKVSPIMPGAYALAGAAAFSGAVTHTLSTALLAFEVSGQIVHALPVLMAVLAANAICQSYQPSFYDGTIIVKKLPYLPWIRGRKIGSHLVTVGHFMNCTLTTLAKDMPLEEVIKVVISTDVTQYPLVETTESQVLVGIVKRTHLVQSLHTDSASWAPGQQPCLQDILANGCPTQPVTLQLSTETSLHETHNLFELLNLQLLFVTSRGRAVGSVSWVELKKAISTLTNPPAPK
uniprot
proteins
function
FUNCTION: Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide (By similarity). Forms a homodimeric channel where each subunit has its own ion conduction pathway. May conduct double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously (By similarity). Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain and functional switch to the ion conducting state. CLCNKB:BSND channels display mostly a linear current-voltage relationship controlled by common gate (By similarity). Mediates chloride conductance along nephron segments, namely the thick ascending limb of Henle's loop, convoluted tubule and the collecting duct, contributing to the maintenance of systemic acid-base and electrolyte homeostasis (By similarity). Conducts chloride currents in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (By similarity). {ECO:0000250|UniProtKB:P51801, ECO:0000250|UniProtKB:Q9WUB6}.
uniprot
proteins
mass_dalton
75218
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P51801}.
uniprot
proteins
protein_family
CLCNKB subfamily
uniprot
proteins
protein_family
Chloride channel (TC 2.A.49) family
uniprot
proteins
pubmed
12111250
uniprot
proteins
pubmed
12761627
uniprot
proteins
pubmed
8021279
uniprot
proteins
pubmed
8041726
uniprot
proteins
sequence_length
687
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:P51801}; Multi-pass membrane protein {ECO:0000255}. Note=Recruited to the plasma membrane in the presence of BSND protein, whereas remains in the Golgi in its absence. {ECO:0000269|PubMed:12761627}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..82; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 91..111; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 141..160; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 161..180; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 236..255; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 282..310; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 325..342; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 400..420; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 421..440; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 500..520; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523
uniprot
proteins