Akirin2
entrez
297968
canonical
uniprot
Q25C79
canonical
ensembl
ENSRNOG00000008288
resolver
ensembl
ENSRNOG00055016103
resolver
ensembl
ENSRNOG00060004914
resolver
ensembl
ENSRNOG00065004924
resolver
ensp
ENSRNOP00000010962
resolver
ensp
ENSRNOP00000105425
resolver
ensp
ENSRNOP00055021961
resolver
ensp
ENSRNOP00060006168
resolver
ensp
ENSRNOP00065004973
resolver
enst
ENSRNOT00000010962
resolver
enst
ENSRNOT00000147111
resolver
enst
ENSRNOT00055027325
resolver
enst
ENSRNOT00060008200
resolver
enst
ENSRNOT00065007171
resolver
genesymbol
Akirin2
resolver
genesymbol_syn
FBI1
resolver
uniprot
A0ABK0L648
resolver
uniprot_entry
A0ABK0L648_RAT
resolver
uniprot_entry
AKIR2_RAT
resolver
amino_acid_sequence
MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPASAAASPAAATAAAAASAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLEASFQQTDPGCSSDSQPHAFLISGPASPGTSSATSSPLKKEQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASYVS
uniprot
proteins
function
FUNCTION: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (By similarity). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (By similarity). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6. Also involved in adaptive immunity by promoting B-cell activation. Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells. Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors. Also plays a role in facilitating interdigital tissue regression during limb development (By similarity). {ECO:0000250|UniProtKB:B1AXD8, ECO:0000250|UniProtKB:Q53H80}.
uniprot
proteins
mass_dalton
22129
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="S->A: Abolishes binding to YWHAB. Reduces transcriptional repressor activity; when associated with A-111 and A-119."; /evidence="ECO:0000269|PubMed:18460465"; MUTAGEN 103; /note="T->A: Abolishes binding to YWHAB. Loss of transcriptional repressor activity; when associated with A-111; A-119 and A-131."; /evidence="ECO:0000269|PubMed:18460465"; MUTAGEN 111; /note="S->A: Abolishes binding to YWHAB. Loss of transcriptional repressor activity; when associated with A-103; A-119 and A-131. Reduces transcriptional repressor activity; when associated with A-31 and A-119."; /evidence="ECO:0000269|PubMed:18460465"; MUTAGEN 119; /note="S->A: Abolishes binding to YWHAB. Loss of transcriptional repressor activity; when associated with A-103; A-111 and A-131. Reduces transcriptional repressor activity; when associated with A-31 and A-111."; /evidence="ECO:0000269|PubMed:18460465"; MUTAGEN 131; /note="S->A: Abolishes binding to YWHAB. Loss of transcriptional repressor activity; when associated with A-103; A-111 and A-119."; /evidence="ECO:0000269|PubMed:18460465
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated. Polyubiquitination is dependent of UBR5 that extends pre-ubiquitinated AKIRIN2. {ECO:0000250|UniProtKB:Q53H80}.
uniprot
proteins
protein_family
Akirin family
uniprot
proteins
pubmed
18460465
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18460465}. Cytoplasm {ECO:0000250|UniProtKB:B1AXD8}. Membrane {ECO:0000250|UniProtKB:B1AXD8}. Note=Present mainly in the nuclear fraction, and at much lower level in the cytoplasmic and membrane fractions. {ECO:0000250|UniProtKB:B1AXD8}.
uniprot
proteins