NUMB
entrez
8650
canonical
uniprot
P49757
canonical
ensembl
ENSG00000133961
resolver
ensp
ENSP00000348644
resolver
ensp
ENSP00000451117
resolver
ensp
ENSP00000451300
resolver
ensp
ENSP00000451625
resolver
ensp
ENSP00000452416
resolver
genesymbol
NUMB
resolver
genesymbol_syn
C14orf41
resolver
hgnc
HGNC:8060
resolver
uniprot
B1P2N5
resolver
uniprot
B1P2N6
resolver
uniprot
B1P2N7
resolver
uniprot
B1P2N8
resolver
uniprot
B1P2N9
resolver
uniprot
B4E2B1
resolver
uniprot
Q6NUQ7
resolver
uniprot
Q86SY1
resolver
uniprot
Q8WW73
resolver
uniprot
Q9UBG1
resolver
uniprot
Q9UEQ4
resolver
uniprot
Q9UKE8
resolver
uniprot
Q9UKE9
resolver
uniprot
Q9UKF0
resolver
uniprot
Q9UQJ4
resolver
uniprot_entry
NUMB_HUMAN
resolver
uniprot_sec
B1P2N5
resolver
uniprot_sec
B1P2N6
resolver
uniprot_sec
B1P2N7
resolver
uniprot_sec
B1P2N8
resolver
uniprot_sec
B1P2N9
resolver
uniprot_sec
B4E2B1
resolver
uniprot_sec
Q6NUQ7
resolver
uniprot_sec
Q86SY1
resolver
uniprot_sec
Q8WW73
resolver
uniprot_sec
Q9UBG1
resolver
uniprot_sec
Q9UEQ4
resolver
uniprot_sec
Q9UKE8
resolver
uniprot_sec
Q9UKE9
resolver
uniprot_sec
Q9UKF0
resolver
uniprot_sec
Q9UQJ4
resolver
amino_acid_sequence
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASADRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL
uniprot
proteins
function
FUNCTION: Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}.
uniprot
proteins
mass_dalton
70804
uniprot
proteins
mutagenesis
MUTAGEN 102; /note="T->A: Loss of AAK1-mediated phosphorylation."; /evidence="ECO:0000269|PubMed:18657069
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-276 and Ser-295 by CaMK1. {ECO:0000250}.; PTM: Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. {ECO:0000250}.
uniprot
proteins
pubmed
10468633
uniprot
proteins
pubmed
11752454
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12775724
uniprot
proteins
pubmed
14670962
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18657069
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21486681
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7596406
uniprot
proteins
pubmed
9303539
uniprot
proteins
sequence_length
651
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18657069}; Peripheral membrane protein {ECO:0000305|PubMed:18657069}; Cytoplasmic side {ECO:0000305|PubMed:18657069}. Endosome membrane {ECO:0000269|PubMed:18657069}; Peripheral membrane protein {ECO:0000305|PubMed:18657069}; Cytoplasmic side {ECO:0000305|PubMed:18657069}. Note=Localizes to perinuclear endosomes in an AAK1-dependent manner. {ECO:0000269|PubMed:18657069}.
uniprot
proteins