Gpr174
entrez
213439
canonical
uniprot
Q3U507
canonical
ensembl
ENSMUSG00000073008
resolver
ensp
ENSMUSP00000098852
resolver
ensp
ENSMUSP00000112808
resolver
ensp
ENSMUSP00000112974
resolver
ensp
ENSMUSP00000113032
resolver
ensp
ENSMUSP00000137372
resolver
enst
ENSMUST00000101294
resolver
enst
ENSMUST00000117310
resolver
enst
ENSMUST00000118820
resolver
enst
ENSMUST00000120971
resolver
enst
ENSMUST00000178838
resolver
genesymbol
Gpr174
resolver
genesymbol_syn
Gm376
resolver
uniprot_entry
GP174_MOUSE
resolver
amino_acid_sequence
MTDNFTCNKTDGDNTDFRYFIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVVFMINLAIADLLQILSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFNDCKQKYDLYISIIGWLIICLACLLFPLLRTNDDTPGNRTKCFVDLPIRNVNLAQSVAMITIGEVVGFVTPLMIVLYCTWKTALSLQNKYPISQHLGEKKKALKMILTCAGVFLVCFVPYHFSFPLDFLVKSNEIKSCFARRVILIFHSVALCLASLNSCLDPVIYYFTTNEFRRRLSRQDLPDNIQLHTKSYKIASNHATSTVAAELC
uniprot
proteins
function
FUNCTION: G protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response. Plays a negative role in regulatory T-cell accumulation and homeostasis (PubMed:26077720). Under inflammatory conditions where LysoPS production increases, contributes to the down-regulation of regulatory T-cell activity to favor effector response (PubMed:26077720). Mediates the suppression of IL-2 production in activated T-lymphocytes leading to inhibition of growth, proliferation and differentiation of T-cells (PubMed:29457279). Mechanistically, acts via G(s)-containing heterotrimeric G proteins to trigger elevated cyclic AMP levels and protein kinase A/PKA activity, which may in turn act to antagonize proximal TCR signaling (PubMed:29457279). Plays an important role in the initial period of sepsis through the regulation of macrophage polarization and pro- and anti-inflammatory cytokine secretions (PubMed:30850582). Upon testosterone treatment, acts as a receptor for CCL21 and subsequently triggers through G(q)-alpha and G(12)/G(13) proteins a calcium flux leading to chemotactic effects on activated B-cells (PubMed:31875850). Signals via GNA13 and PKA to promote CD86 up-regulation by follicular B-cells (PubMed:35639700). {ECO:0000269|PubMed:26077720, ECO:0000269|PubMed:29457279, ECO:0000269|PubMed:30850582, ECO:0000269|PubMed:31875850, ECO:0000269|PubMed:35639700}.
uniprot
proteins
mass_dalton
38761
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23178570
uniprot
proteins
pubmed
26077720
uniprot
proteins
pubmed
29457279
uniprot
proteins
pubmed
30850582
uniprot
proteins
pubmed
31875850
uniprot
proteins
pubmed
35639700
uniprot
proteins
sequence_length
335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 28..48; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 54..74; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 135..155; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins