AKIRIN2
entrez
55122
canonical
uniprot
Q53H80
canonical
ensembl
ENSG00000135334
resolver
ensp
ENSP00000257787
resolver
enst
ENST00000257787
resolver
genesymbol
AKIRIN2
resolver
genesymbol_syn
C6orf166
resolver
hgnc
HGNC:21407
resolver
uniprot
Q9BQB1
resolver
uniprot
Q9NW35
resolver
uniprot_entry
AKIR2_HUMAN
resolver
uniprot_entry
Q9NW35_HUMAN
resolver
uniprot_sec
Q9BQB1
resolver
amino_acid_sequence
MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPTSAAASPLSAAAATAASFSAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLETSFQQTDPCCTSDAQPHAFLLSGPASPGTSSAASSPLKKEQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASYVS
uniprot
proteins
function
FUNCTION: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:34711951). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (PubMed:34711951). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity). {ECO:0000250|UniProtKB:B1AXD8, ECO:0000269|PubMed:34711951}.
uniprot
proteins
mass_dalton
22496
uniprot
proteins
mutagenesis
MUTAGEN 201..203; /note="Missing: Abolished association with the 20S and 26S proteasomes."; /evidence="ECO:0000269|PubMed:34711951
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated (PubMed:37409633). Polyubiquitination is dependent of UBR5 that extends pre-ubiquitinated AKIRIN2 (PubMed:37409633). {ECO:0000269|PubMed:37409633}.
uniprot
proteins
protein_family
Akirin family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18066067
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
34711951
uniprot
proteins
pubmed
37409633
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18066067, ECO:0000269|PubMed:34711951}. Cytoplasm {ECO:0000250|UniProtKB:B1AXD8}. Membrane {ECO:0000250|UniProtKB:B1AXD8}. Note=Present mainly in the nuclear fraction, and at much lower level in the cytoplasmic and membrane fractions. {ECO:0000250|UniProtKB:B1AXD8}.
uniprot
proteins