Nox1
entrez
237038
canonical
uniprot
Q8CIZ9
canonical
ensembl
ENSMUSG00000031257
resolver
ensp
ENSMUSP00000033610
resolver
genesymbol
Nox1
resolver
uniprot
A2AEK5
resolver
uniprot
Q0KKX3
resolver
uniprot
Q0KKX5
resolver
uniprot
Q811U2
resolver
uniprot_entry
NOX1_MOUSE
resolver
uniprot_sec
A2AEK5
resolver
uniprot_sec
Q0KKX3
resolver
uniprot_sec
Q0KKX5
resolver
uniprot_sec
Q811U2
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform 2]: The oxidase activity is potentiated by NOXA1 and NOXO1. {ECO:0000269|PubMed:12473664}.
uniprot
proteins
amino_acid_sequence
MAGELRGSRGPLQRIQIAPREAPNLHLTMGNWLVNHWLSVLFLVSWLGLNIFLFVYAFLNYEKSDKYYYTREILGTALALARASALCLNFNSMMILIPVCRNLLSFLRGTCSFCNRTLRKPLDHNLTFHKLVAYMICIFTVIHIIAHLFNFERYRRSQQAMDGSLASVLSSLSHPEKEDSWLNPIQSPNMTVMYAAFTSIAGLTGVIATVALVLMVTSAMEFIRRNYFELFWYTHHLFIVYIICLGIHGLGGIVRGQTEESLGESHPHNCSHSFHEWDDHKGSCRHPHFAGHPPESWKWILAPIAFYIFERILRFYRSQQKVVITKVVMHPSNVLELQMRKRGFSMEVGQYIFVNCPSISFLEWHPFTLTSAPEEEFFSVHIRAAGDWTRNLIRTFEQQHSPMPRIEVDGPFGTVSEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQRADNKLKTQKIYFYWICRETGAFAWFNNLLNSLEQEMEELGKMDFLNYRLFLTGWDSNIAGHAALNFDRATDILTGLKQKTSFGRPMWDNEFSRIATAHPKSAVGVFLCGPRTLAKSLRKRCQRYSSLDPRKVQFYFNKETF
uniprot
proteins
ec_number
1.6.3.-
uniprot
proteins
function
FUNCTION: [Isoform 1]: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. {ECO:0000269|PubMed:16724959}.; FUNCTION: [Isoform 2]: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. {ECO:0000269|PubMed:12473664, ECO:0000269|PubMed:16724959}.
uniprot
proteins
mass_dalton
68193
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-457 mediated by PKC/PRKBC positively regulates its interaction with NOXA1 and enzyme activity. {ECO:0000250|UniProtKB:Q9WV87}.
uniprot
proteins
pubmed
12473664
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16724959
uniprot
proteins
pubmed
16814099
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, invadopodium membrane {ECO:0000250|UniProtKB:Q9Y5S8}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9Y5S8}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..59; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 73..97; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 131..151; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 235..255; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 424..444; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins