Cyp2e1
entrez
25086
canonical
uniprot
P05182
canonical
ensembl
ENSRNOG00000012458
resolver
ensp
ENSRNOP00000016883
resolver
genesymbol
Cyp2e1
resolver
genesymbol_syn
Cyp2e
resolver
genesymbol_syn
Cyp2e-1
resolver
uniprot_entry
CP2E1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: The omega-1 hydroxylase activity is stimulated by cytochrome b5. {ECO:0000250|UniProtKB:P05181}.
uniprot
proteins
amino_acid_sequence
MAVLGITIALLVWVATLLVISIWKQIYNSWNLPPGPFPLPILGNIFQLDLKDIPKSFTKLAKRFGPVFTLHLGSRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYKNKGIIFNNGPTWKDVRRFSLSILRDWGMGKQGNEARIQREAQFLVEELKKTKGQPFDPTFLIGCAPCNVIADILFNKRFDYNDKKCLRLMSLFNENFYLLSTPWIQLYNNFADYLRYLPGSHRKIMKNVSEIKQYTLEKAKEHLQSLDINCARDVTDCLLIEMEKEKHSQEPMYTMENVSVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRVPAVRDRLDMPYMDAVVHEIQRFINLVPSNLPHEATRDTVFQGYVIPKGTVVIPTLDSLLYDSHEFPDPEKFKPEHFLNENGKFKYSDYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTVGFGSIPPQFKLCVIPRS
uniprot
proteins
ec_number
1.14.13.n7
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. {ECO:0000250|UniProtKB:P05181}.
uniprot
proteins
mass_dalton
56627
uniprot
proteins
mutagenesis
MUTAGEN 129; /note="S->A: Reduces interaction with HSP70; impairs interaction with HSP90."; /evidence="ECO:0000269|PubMed:19401463
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000250|UniProtKB:P05181}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
1441586
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19401463
uniprot
proteins
pubmed
2321956
uniprot
proteins
pubmed
2832413
uniprot
proteins
pubmed
3308889
uniprot
proteins
pubmed
3782137
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:19401463}; Peripheral membrane protein. Microsome membrane {ECO:0000305|PubMed:19401463}; Peripheral membrane protein. Mitochondrion inner membrane {ECO:0000305|PubMed:19401463}; Peripheral membrane protein {ECO:0000305|PubMed:19401463}. Note=Post-translationally targeted to mitochondria. TOMM70 is required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein. {ECO:0000305|PubMed:19401463}.
uniprot
proteins