Bsg
entrez
25246
canonical
uniprot
P26453
canonical
ensembl
ENSRNOG00000008414
resolver
ensembl
ENSRNOG00055031052
resolver
ensembl
ENSRNOG00060027051
resolver
ensembl
ENSRNOG00065020463
resolver
ensp
ENSRNOP00000011275
resolver
ensp
ENSRNOP00000050252
resolver
genesymbol
Bsg
resolver
uniprot
Q6GT74
resolver
uniprot
Q7TNP1
resolver
uniprot_entry
BASI_RAT
resolver
uniprot_entry
Q6GT74_RAT
resolver
uniprot_sec
Q7TNP1
resolver
amino_acid_sequence
MAAALLLALAFTFLSGQGACAAAGFLKAPMSQEQWAGGSVVLHCEAVGSPMPEIQWWFEGNEPNDSCSQLWDGARLDRVHIHATYRQHAASTLSVDGLAAEDTGTYECRASSDPDRNHLTRPPRVKWVRAQASVVVLEPGTIVTSVQEVDSKTQLTCFLNSSGIDIVGHRWMRGGKVLQEDTLPDLQMKYTVDADDRSGEYSCIFLPEPVGRGNINVEGPPRIKVGKKSEHASEGEFVKLICKSEASHPPVDEWVWFKTSDTGDQTISNGTEANSKYVIISTPELSELIISDLDMNVDPGTYVCNATNSQGSARETISLRVRSRLAALWPFLGIVAEVLVLVTIIFIYEKRRKPDQTLDEDDPGAAPLKGSGSHLNDKDKNVRQRNAT
uniprot
proteins
function
FUNCTION: [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (By similarity). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (By similarity). {ECO:0000250|UniProtKB:P18572}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity). Plays an important role in targeting the monocarboxylate transporters SLC16A1/GLUT1 and SLC16A3 to the plasma membrane (PubMed:10921872). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity). Plays an important role in spermatogenesis; mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids (By similarity). {ECO:0000250|UniProtKB:P18572, ECO:0000250|UniProtKB:P35613, ECO:0000269|PubMed:10921872}.; FUNCTION: Plays a role in neurite outgrowth. {ECO:0000250|UniProtKB:P18572}.
uniprot
proteins
mass_dalton
42436
uniprot
proteins
pubmed
10921872
uniprot
proteins
pubmed
11719518
uniprot
proteins
pubmed
12141934
uniprot
proteins
pubmed
12939332
uniprot
proteins
pubmed
2009910
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
35257743
uniprot
proteins
pubmed
8425897
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:P35613}; Single-pass type I membrane protein {ECO:0000303|PubMed:11719518}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P18572}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P18572}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11719518}; Single-pass type I membrane protein {ECO:0000303|PubMed:11719518}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P35613}; Single-pass type I membrane protein {ECO:0000303|PubMed:11719518}. Basolateral cell membrane {ECO:0000250|UniProtKB:P35613}; Single-pass type I membrane protein {ECO:0000303|PubMed:11719518}.
uniprot
proteins
transmembrane_region
TRANSMEM 327..347; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins