INTS12
entrez
57117
canonical
uniprot
Q96CB8
canonical
ensembl
ENSG00000138785
resolver
ensp
ENSP00000340737
resolver
ensp
ENSP00000378221
resolver
ensp
ENSP00000415433
resolver
ensp
ENSP00000561101
resolver
ensp
ENSP00000561102
resolver
ensp
ENSP00000561105
resolver
ensp
ENSP00000561107
resolver
ensp
ENSP00000561110
resolver
ensp
ENSP00000561111
resolver
ensp
ENSP00000561112
resolver
ensp
ENSP00000561113
resolver
ensp
ENSP00000561114
resolver
ensp
ENSP00000561115
resolver
ensp
ENSP00000561116
resolver
ensp
ENSP00000561117
resolver
ensp
ENSP00000561118
resolver
ensp
ENSP00000561119
resolver
ensp
ENSP00000561120
resolver
ensp
ENSP00000561121
resolver
ensp
ENSP00000595894
resolver
ensp
ENSP00000595897
resolver
ensp
ENSP00000617285
resolver
enst
ENST00000340139
resolver
enst
ENST00000394735
resolver
enst
ENST00000451321
resolver
enst
ENST00000891042
resolver
enst
ENST00000891043
resolver
enst
ENST00000891046
resolver
enst
ENST00000891048
resolver
enst
ENST00000891051
resolver
enst
ENST00000891052
resolver
enst
ENST00000891053
resolver
enst
ENST00000891054
resolver
enst
ENST00000891055
resolver
enst
ENST00000891056
resolver
enst
ENST00000891057
resolver
enst
ENST00000891058
resolver
enst
ENST00000891059
resolver
enst
ENST00000891060
resolver
enst
ENST00000891061
resolver
enst
ENST00000891062
resolver
enst
ENST00000925835
resolver
enst
ENST00000925838
resolver
enst
ENST00000947226
resolver
genesymbol
INTS12
resolver
genesymbol_syn
PHF22
resolver
hgnc
HGNC:25067
resolver
uniprot
B2RC48
resolver
uniprot
Q3B6Z3
resolver
uniprot
Q9HD71
resolver
uniprot_entry
INT12_HUMAN
resolver
uniprot_sec
B2RC48
resolver
uniprot_sec
Q3B6Z3
resolver
uniprot_sec
Q9HD71
resolver
amino_acid_sequence
MAATVNLELDPIFLKALGFLHSKSKDSAEKLKALLDESLARGIDSSYRPSQKDVEPPKISSTKNISIKQEPKISSSLPSGNNNGKVLTTEKVKKEAEKRPADKMKSDITEGVDIPKKPRLEKPETQSSPITVQSSKDLPMADLSSFEETSADDFAMEMGLACVVCRQMMVASGNQLVECQECHNLYHRDCHKPQVTDKEANDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPAVVSVTPAVKDPLVKKPETKLKQETTFLAFKRTEVKTSTVISGNSSSASVSSSVTSGLTGWAAFAAKTSSAGPSTAKLSSTTQNNTGKPATSSANQKPVGLTGLATSSKGGIGSKIGSNNSTTPTVPLKPPPPLTLGKTGLSRSVSCDNVSKVGLPSPSSLVPGSSSQLSGNGNSGTSGPSGSTTSKTTSESSSSPSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:38570683}.
uniprot
proteins
mass_dalton
48808
uniprot
proteins
post_translational_modification
PTM: Dephosphorylated at Ser-128 by the PNUTS-PP1 complex, promoting RNA polymerase II transcription pause-release. {ECO:0000269|PubMed:39603240}.
uniprot
proteins
protein_family
Integrator subunit 12 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16239144
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23904267
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
38570683
uniprot
proteins
pubmed
39032490
uniprot
proteins
pubmed
39603240
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:39032490}.
uniprot
proteins