Anxa1
entrez
16952
canonical
uniprot
P10107
canonical
ensembl
ENSMUSG00000024659
resolver
ensp
ENSMUSP00000025561
resolver
ensp
ENSMUSP00000158305
resolver
enst
ENSMUST00000025561
resolver
enst
ENSMUST00000235280
resolver
genesymbol
Anxa1
resolver
genesymbol_syn
Anx1
resolver
genesymbol_syn
Lpc-1
resolver
genesymbol_syn
Lpc1
resolver
uniprot
Q4FJV4
resolver
uniprot_entry
ANXA1_MOUSE
resolver
uniprot_entry
Q4FJV4_MOUSE
resolver
amino_acid_sequence
MAMVSEFLKQARFLENQEQEYVQAVKSYKGGPGSAVSPYPSFNVSSDVAALHKAIMVKGVDEATIIDILTKRTNAQRQQIKAAYLQENGKPLDEVLRKALTGHLEEVVLAMLKTPAQFDADELRGAMKGLGTDEDTLIEILTTRSNEQIREINRVYREELKRDLAKDITSDTSGDFRKALLALAKGDRCQDLSVNQDLADTDARALYEAGERRKGTDVNVFTTILTSRSFPHLRRVFQNYGKYSQHDMNKALDLELKGDIEKCLTTIVKCATSTPAFFAEKLYEAMKGAGTRHKALIRIMVSRSEIDMNEIKVFYQKKYGISLCQAILDETKGDYEKILVALCGGN
uniprot
proteins
function
FUNCTION: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:12475898). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (PubMed:12475898). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T cells (PubMed:17948261). Promotes the differentiation of T cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17948261). Has no effect on unstimulated T cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (By similarity). Plays a role in the formation of phagocytic cups and phagosomes (PubMed:21245195). Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (PubMed:21245195). In the context of antitumor immunity, interacts with FPR1 on dendritic cells allowing for tumor-associated antigens uptake and cross-presentation to T cells to mount an antitumor specific T cell response. {ECO:0000250|UniProtKB:P04083, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:12475898, ECO:0000269|PubMed:17948261, ECO:0000269|PubMed:21245195, ECO:0000269|PubMed:25664854, ECO:0000269|PubMed:26516201}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2. {ECO:0000250|UniProtKB:P04083}.
uniprot
proteins
mass_dalton
38734
uniprot
proteins
mutagenesis
MUTAGEN 257; /note="K->R: Strongly decreased sumoylation."; /evidence="ECO:0000269|PubMed:23727357
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by protein kinase C, EGFR and TRPM7. Phosphorylated in response to EGF treatment. {ECO:0000250|UniProtKB:P04083}.; PTM: Sumoylated. {ECO:0000269|PubMed:23727357}.; PTM: Proteolytically cleaved by cathepsin CTSG to release the active N-terminal peptide Ac2-26. {ECO:0000250|UniProtKB:P04083}.
uniprot
proteins
protein_family
Annexin family
uniprot
proteins
pubmed
12475898
uniprot
proteins
pubmed
14506282
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1676980
uniprot
proteins
pubmed
17384087
uniprot
proteins
pubmed
17948261
uniprot
proteins
pubmed
18641677
uniprot
proteins
pubmed
18802107
uniprot
proteins
pubmed
19104500
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21245195
uniprot
proteins
pubmed
23727357
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
2522299
uniprot
proteins
pubmed
25664854
uniprot
proteins
pubmed
26516201
uniprot
proteins
pubmed
2974946
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P07150}. Cytoplasm {ECO:0000269|PubMed:18802107, ECO:0000269|PubMed:21245195}. Cell projection, cilium {ECO:0000269|PubMed:17384087}. Basolateral cell membrane {ECO:0000250|UniProtKB:P51662}. Lateral cell membrane {ECO:0000269|PubMed:18802107}. Cell membrane {ECO:0000269|PubMed:14506282, ECO:0000269|PubMed:21245195}; Peripheral membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:17384087, ECO:0000269|PubMed:18802107}. Membrane {ECO:0000269|PubMed:23727357}; Peripheral membrane protein {ECO:0000269|PubMed:23727357}. Early endosome {ECO:0000250|UniProtKB:P19619}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P19619}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19619}. Endosome membrane {ECO:0000250|UniProtKB:P07150}; Peripheral membrane protein {ECO:0000250|UniProtKB:P07150}. Secreted {ECO:0000269|PubMed:25664854}. Secreted, extracellular space {ECO:0000250|UniProtKB:P04083}. Cell membrane {ECO:0000250|UniProtKB:P04083}; Peripheral membrane protein {ECO:0000250|UniProtKB:P04083}; Extracellular side {ECO:0000250|UniProtKB:P04083}. Secreted, extracellular exosome {ECO:0000269|PubMed:25664854}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000269|PubMed:25664854}. Cell projection, phagocytic cup {ECO:0000269|PubMed:21245195}. Note=Colocalizes with actin fibers at phagocytic cups (PubMed:21245195). Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Secretion is increased in response to wounding and inflammation (PubMed:25664854). Detected in gelatinase granules in resting neutrophils. Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect. Displays calcium-dependent binding to phospholipid membranes (By similarity). {ECO:0000250|UniProtKB:P04083, ECO:0000269|PubMed:25664854}.
uniprot
proteins