HSD17B6
entrez
8630
canonical
uniprot
O14756
canonical
ensembl
ENSG00000025423
resolver
ensp
ENSP00000318631
resolver
ensp
ENSP00000450698
resolver
ensp
ENSP00000451406
resolver
ensp
ENSP00000451753
resolver
ensp
ENSP00000452273
resolver
ensp
ENSP00000529715
resolver
ensp
ENSP00000529716
resolver
ensp
ENSP00000529717
resolver
ensp
ENSP00000529718
resolver
ensp
ENSP00000529720
resolver
ensp
ENSP00000529721
resolver
ensp
ENSP00000529722
resolver
ensp
ENSP00000529723
resolver
ensp
ENSP00000529724
resolver
ensp
ENSP00000529725
resolver
ensp
ENSP00000529726
resolver
ensp
ENSP00000529727
resolver
ensp
ENSP00000529728
resolver
ensp
ENSP00000529729
resolver
ensp
ENSP00000529730
resolver
ensp
ENSP00000529731
resolver
ensp
ENSP00000529732
resolver
ensp
ENSP00000529735
resolver
ensp
ENSP00000529736
resolver
ensp
ENSP00000529737
resolver
ensp
ENSP00000529738
resolver
ensp
ENSP00000529739
resolver
ensp
ENSP00000529740
resolver
ensp
ENSP00000529741
resolver
ensp
ENSP00000529742
resolver
ensp
ENSP00000529743
resolver
ensp
ENSP00000529744
resolver
ensp
ENSP00000603001
resolver
ensp
ENSP00000603002
resolver
ensp
ENSP00000612560
resolver
ensp
ENSP00000612561
resolver
ensp
ENSP00000676739
resolver
ensp
ENSP00000789153
resolver
enst
ENST00000322165
resolver
enst
ENST00000554150
resolver
enst
ENST00000554643
resolver
enst
ENST00000555159
resolver
enst
ENST00000555805
resolver
enst
ENST00000859656
resolver
enst
ENST00000859657
resolver
enst
ENST00000859658
resolver
enst
ENST00000859659
resolver
enst
ENST00000859661
resolver
enst
ENST00000859662
resolver
enst
ENST00000859663
resolver
enst
ENST00000859664
resolver
enst
ENST00000859665
resolver
enst
ENST00000859666
resolver
enst
ENST00000859667
resolver
enst
ENST00000859668
resolver
enst
ENST00000859669
resolver
enst
ENST00000859670
resolver
enst
ENST00000859671
resolver
enst
ENST00000859672
resolver
enst
ENST00000859673
resolver
enst
ENST00000859676
resolver
enst
ENST00000859677
resolver
enst
ENST00000859678
resolver
enst
ENST00000859679
resolver
enst
ENST00000859680
resolver
enst
ENST00000859681
resolver
enst
ENST00000859682
resolver
enst
ENST00000859683
resolver
enst
ENST00000859684
resolver
enst
ENST00000859685
resolver
enst
ENST00000932942
resolver
enst
ENST00000932943
resolver
enst
ENST00000942501
resolver
enst
ENST00000942502
resolver
genesymbol
HSD17B6
resolver
genesymbol_syn
RODH
resolver
genesymbol_syn
SDR9C6
resolver
hgnc
HGNC:23316
resolver
uniprot
A0A219K5H4
resolver
uniprot
A0A219K684
resolver
uniprot
O43275
resolver
uniprot_entry
A0A219K5H4_HUMAN
resolver
uniprot_entry
A0A219K684_HUMAN
resolver
uniprot_entry
H17B6_HUMAN
resolver
uniprot_sec
O43275
resolver
amino_acid_sequence
MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADYILTRSWPKPAQAV
uniprot
proteins
ec_number
1.1.1.105
uniprot
proteins
ec_number
1.1.1.209
uniprot
proteins
ec_number
1.1.1.239
uniprot
proteins
ec_number
1.1.1.53
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
function
FUNCTION: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. {ECO:0000269|PubMed:10896656, ECO:0000269|PubMed:11360992, ECO:0000269|PubMed:11513953}.
uniprot
proteins
mass_dalton
35966
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
10896656
uniprot
proteins
pubmed
11360992
uniprot
proteins
pubmed
11513953
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9188497
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:11360992}; Peripheral membrane protein {ECO:0000269|PubMed:11360992}; Lumenal side {ECO:0000269|PubMed:11360992}. Early endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Lumenal side {ECO:0000305}.
uniprot
proteins