Rec8
entrez
290227
canonical
uniprot
Q6AYJ4
canonical
ensembl
ENSRNOG00000019503
resolver
ensembl
ENSRNOG00055012593
resolver
ensembl
ENSRNOG00060023402
resolver
ensembl
ENSRNOG00065033488
resolver
ensp
ENSRNOP00000026430
resolver
ensp
ENSRNOP00055017390
resolver
ensp
ENSRNOP00060033503
resolver
ensp
ENSRNOP00065047388
resolver
enst
ENSRNOT00000026430
resolver
enst
ENSRNOT00055021475
resolver
enst
ENSRNOT00060040538
resolver
enst
ENSRNOT00065057566
resolver
genesymbol
Rec8
resolver
genesymbol_syn
Rec8L1
resolver
uniprot
Q6QQR2
resolver
uniprot_entry
REC8_RAT
resolver
uniprot_sec
Q6QQR2
resolver
amino_acid_sequence
MFYYPNVLQRHTGCFATIWLAATRGSRLVKREYLKVNVVKTCEEILNYVLVRVQPPMPGLPRPRFSLYLSAQLQIGVIRVYFQQCQYLVEDIQHILEHLHRAQLRIRIDMEEADLPSLLLPNCLAMMETLEDAPEPFFGTMSVDPTLPSPFDIPQIRHLLEAATPEKIREETLPEATPEPRKPDRTLAMVQSPEVITLQEAEPIRMLRIEGEQDLPEISRGDLDLLIAEEDDAILLEERQRGRLLRQRRASPPLDESKEEPRALEGDGLVSSLSPPAPAQVEGIREPLPDQAFPPEVQKMPGWEPGVLLTEVTPPQELRLPAPPSIEKRPPSPQRPPRRRRRGRQLLFWDKETQISREKFEEQLQTGAHCCEYPVVQPPKRKLMSPAELFRTPTLSGWLSPELLALWTHCAQVPPRMLRQRPQLETEETVEEERVADKEERRKTEALSEIEVLREAQEPSGPLMLSSELSLEVAEEEKSRTSFIPPEERWAWIEERQPEPPALPMLPELPEVPMEMPPGPELLSSEAVLRAVALELQANREPDFSSLVPPLSSRKLASRVFYLLLVLSAQKILLVDQQKPYGRLLIRLGPKFP
uniprot
proteins
function
FUNCTION: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity). {ECO:0000250|UniProtKB:Q8C5S7}.
uniprot
proteins
mass_dalton
67874
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:12615909}.
uniprot
proteins
protein_family
Rad21 family
uniprot
proteins
pubmed
12615909
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
593
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12615909}. Chromosome {ECO:0000269|PubMed:12615909}. Chromosome, centromere {ECO:0000269|PubMed:12615909}. Note=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II. {ECO:0000269|PubMed:12615909}.
uniprot
proteins