DNAJB1
entrez
3337
canonical
uniprot
P25685
canonical
ensembl
ENSG00000132002
resolver
ensp
ENSP00000254322
resolver
ensp
ENSP00000444212
resolver
ensp
ENSP00000470063
resolver
ensp
ENSP00000471073
resolver
ensp
ENSP00000471798
resolver
ensp
ENSP00000472886
resolver
ensp
ENSP00000504527
resolver
genesymbol
DNAJB1
resolver
genesymbol_syn
DNAJ1
resolver
genesymbol_syn
HDJ1
resolver
genesymbol_syn
HSPF1
resolver
hgnc
HGNC:5270
resolver
uniprot
B4DX52
resolver
uniprot
Q6FHS4
resolver
uniprot_entry
DNJB1_HUMAN
resolver
uniprot_entry
Q6FHS4_HUMAN
resolver
uniprot_sec
B4DX52
resolver
amino_acid_sequence
MGKDYYQTLGLARGASDEEIKRAYRRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRKREIFDRYGEEGLKGSGPSGGSGGGANGTSFSYTFHGDPHAMFAEFFGGRNPFDTFFGQRNGEEGMDIDDPFSGFPMGMGGFTNVNFGRSRSAQEPARKKQDPPVTHDLRVSLEEIYSGCTKKMKISHKRLNPDGKSIRNEDKILTIEVKKGWKEGTKITFPKEGDQTSNNIPADIVFVLKDKPHNIFKRDGSDVIYPARISLREALCGCTVNVPTLDGRTIPVVFKDVIRPGMRRKVPGEGLPLPKTPEKRGDLIIEFEVIFPERIPQTSRTVLEQVLPI
uniprot
proteins
function
FUNCTION: Interacts with HSP70 and can stimulate its ATPase activity. Acts also with TTC1 as a chaperone adapter that regulates HSP70-dependent folding process by interacting with the HSP70 amino terminal region (PubMed:14503850). Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:14503850, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9499401}.
uniprot
proteins
mass_dalton
38044
uniprot
proteins
pubmed
14503850
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1586970
uniprot
proteins
pubmed
1754405
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24318877
uniprot
proteins
pubmed
30559338
uniprot
proteins
pubmed
8250930
uniprot
proteins
pubmed
8764402
uniprot
proteins
pubmed
8975727
uniprot
proteins
pubmed
9499401
uniprot
proteins
pubmed
9920933
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1586970}. Nucleus {ECO:0000269|PubMed:1586970}. Nucleus, nucleolus {ECO:0000269|PubMed:1586970}. Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.
uniprot
proteins