Rlim
entrez
19820
canonical
uniprot
Q9WTV7
canonical
ensembl
ENSMUSG00000056537
resolver
ensp
ENSMUSP00000070662
resolver
ensp
ENSMUSP00000112820
resolver
ensp
ENSMUSP00000177040
resolver
ensp
ENSMUSP00000177041
resolver
ensp
ENSMUSP00000177042
resolver
ensp
ENSMUSP00000177043
resolver
ensp
ENSMUSP00000177044
resolver
ensp
ENSMUSP00000177045
resolver
ensp
ENSMUSP00000177046
resolver
ensp
ENSMUSP00000339868
resolver
enst
ENSMUST00000070705
resolver
enst
ENSMUST00000121153
resolver
genesymbol
Rlim
resolver
genesymbol_syn
Rnf12
resolver
uniprot
Q8CE02
resolver
uniprot
Q91X19
resolver
uniprot
Q9CYY2
resolver
uniprot_entry
RNF12_MOUSE
resolver
uniprot_sec
Q8CE02
resolver
uniprot_sec
Q91X19
resolver
uniprot_sec
Q9CYY2
resolver
amino_acid_sequence
MENSDSNDKGSDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGESTEEELLRRLQQIKEGPPPQSPDENRAGESSDDVTNSDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQTSENESEPSTRRLSVENMESSSQRQMENSASESASARPSRAERNSAEAVTEVPTTRAQRRARSRSPEHRRTRARAERSRSPLQPTSEIPRRAPTLEQSSENEPEGSSRTRHHVTLRQQISGPELLGRGLFAASGSRNPSQGTSSSDTGSNSESSGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQAPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPSASVSSRNVERVESRNGRGSSGGGNSSGSSSSSSPSPSSSGESSESSSEMFEGSSEGGSSGPSRRDGRHRAPVTFDESGSLPFLSLAQFFLLNEDDEDQPRGLTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAVLSSGNRESVV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42/REX1 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. E3 ubiquitin-protein ligase is required for proper regulation of neural cell differentiation from embryonic stem cells (PubMed:29742418). {ECO:0000269|PubMed:10431247, ECO:0000269|PubMed:11882901, ECO:0000269|PubMed:19945382, ECO:0000269|PubMed:22596162, ECO:0000269|PubMed:29742418}.
uniprot
proteins
mass_dalton
66377
uniprot
proteins
mutagenesis
MUTAGEN 575; /note="R->C: Decreased ZFP42/REX1 substrate proteasomal degradation. Results in accelerated neural cell differentiation from embryonic stem cells."; /evidence="ECO:0000269|PubMed:29742418
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
RNF12 family
uniprot
proteins
pubmed
10431247
uniprot
proteins
pubmed
11882901
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16204183
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19945382
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22596162
uniprot
proteins
pubmed
29742418
uniprot
proteins
sequence_length
600
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19945382}.
uniprot
proteins