S100b
entrez
25742
canonical
uniprot
P04631
canonical
ensembl
ENSRNOG00000001295
resolver
ensembl
ENSRNOG00055022964
resolver
ensembl
ENSRNOG00060024014
resolver
ensembl
ENSRNOG00065025565
resolver
ensp
ENSRNOP00000001743
resolver
ensp
ENSRNOP00055032032
resolver
ensp
ENSRNOP00060034444
resolver
ensp
ENSRNOP00065036114
resolver
enst
ENSRNOT00000001743
resolver
enst
ENSRNOT00055039457
resolver
enst
ENSRNOT00060041565
resolver
enst
ENSRNOT00065044031
resolver
genesymbol
S100b
resolver
uniprot_entry
S100B_RAT
resolver
amino_acid_sequence
MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDEDGDGECDFQEFMAFVSMVTTACHEFFEHE
uniprot
proteins
function
FUNCTION: Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (PubMed:14621986, PubMed:15823027, PubMed:18949447, PubMed:20351179). Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer (PubMed:15823027). Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites (By similarity). Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation (By similarity). Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue (By similarity). Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase (By similarity). Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (PubMed:19910580). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity). May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity). {ECO:0000250|UniProtKB:P02638, ECO:0000250|UniProtKB:P04271, ECO:0000250|UniProtKB:P50114, ECO:0000269|PubMed:14621986, ECO:0000269|PubMed:15823027, ECO:0000269|PubMed:18949447, ECO:0000269|PubMed:19910580, ECO:0000269|PubMed:20351179}.
uniprot
proteins
mass_dalton
10744
uniprot
proteins
mutagenesis
MUTAGEN 16; /note="H->A: Decreased zinc-binding."; /evidence="ECO:0000269|PubMed:14621986"; MUTAGEN 26; /note="H->A: Decreased zinc-binding."; /evidence="ECO:0000269|PubMed:14621986"; MUTAGEN 43; /note="H->A: Does not affect zinc-binding."; /evidence="ECO:0000269|PubMed:14621986"; MUTAGEN 69; /note="C->A: Does not affect zinc-binding."; /evidence="ECO:0000269|PubMed:14621986"; MUTAGEN 85; /note="C->A: Decreased zinc-binding."; /evidence="ECO:0000269|PubMed:14621986"; MUTAGEN 86; /note="H->A: Decreased zinc-binding."; /evidence="ECO:0000269|PubMed:14621986"; MUTAGEN 91; /note="H->A: Decreased zinc-binding."; /evidence="ECO:0000269|PubMed:14621986
uniprot
proteins
protein_family
S-100 family
uniprot
proteins
pubmed
10211826
uniprot
proteins
pubmed
12042313
uniprot
proteins
pubmed
12470955
uniprot
proteins
pubmed
14621986
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15823027
uniprot
proteins
pubmed
1653388
uniprot
proteins
pubmed
18949447
uniprot
proteins
pubmed
19910580
uniprot
proteins
pubmed
20351179
uniprot
proteins
pubmed
3818655
uniprot
proteins
pubmed
6093041
uniprot
proteins
pubmed
8794737
uniprot
proteins
pubmed
9485423
uniprot
proteins
sequence_length
92
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P04271}. Nucleus {ECO:0000250|UniProtKB:P04271}. Secreted {ECO:0000250|UniProtKB:P50114}. Note=Secretion into the medium is promoted by interaction with isoform CLSTN3beta of CLSTN3. {ECO:0000250|UniProtKB:P50114}.
uniprot
proteins