Ciita
entrez
12265
canonical
uniprot
P79621
canonical
ensembl
ENSMUSG00000022504
resolver
ensp
ENSMUSP00000023147
resolver
ensp
ENSMUSP00000154946
resolver
ensp
ENSMUSP00000155002
resolver
ensp
ENSMUSP00000155517
resolver
ensp
ENSMUSP00000170860
resolver
enst
ENSMUST00000230146
resolver
genesymbol
Ciita
resolver
genesymbol_syn
C2ta
resolver
genesymbol_syn
Mhc2ta
resolver
uniprot
A0A2R8VHC7
resolver
uniprot
O46787
resolver
uniprot
O78036
resolver
uniprot
O78109
resolver
uniprot
Q31115
resolver
uniprot
Q3KNE0
resolver
uniprot
Q3U5G4
resolver
uniprot
Q3UNW8
resolver
uniprot
Q3UU40
resolver
uniprot
Q8HW99
resolver
uniprot
Q9TPP1
resolver
uniprot_entry
A0A2R8VHC7_MOUSE
resolver
uniprot_entry
C2TA_MOUSE
resolver
uniprot_entry
Q3KNE0_MOUSE
resolver
uniprot_entry
Q3U5G4_MOUSE
resolver
uniprot_entry
Q3UNW8_MOUSE
resolver
uniprot_entry
Q3UU40_MOUSE
resolver
uniprot_entry
Q8HW99_MOUSE
resolver
uniprot_sec
O46787
resolver
uniprot_sec
O78036
resolver
uniprot_sec
O78109
resolver
uniprot_sec
Q31115
resolver
uniprot_sec
Q9TPP1
resolver
amino_acid_sequence
MNHFQAILAQVQTLLSSQKPRQVRALLDGLLEEELLSREYHCALLHEPDGDALARKISLTLLEKGDLDLTFLSWVCNSLQAPTVERGTSYRDHGDHSLCATMDLGSPEGSYLELLNSDADPLHLYHLYDQMDLAGEEEIELSSEPDTDTINCDQFSKLLQDMELDEETREAYANIAELDQYVFQDTQLEGLSKDLFIEHIGAEEGFGENIEIPVEAGQKPQKRRFPEEHAMDSKHRKLVPTSRTSLNYLDLPTGHIQIFTTLPQGLWQISGAGTGLSSVLIYHGEMPQVNQVLPSSSLSIPSLPESPDRPGSTSPFTPSAADLPSMPEPALTSRVNETEDTSPSPCQEGPESSIKLPKWPEAVERFQHSLQDKYKALPQSPRGPLVAVELVRARLERGSNKSQERELATPDWTERQLAHGGLAEVLQVVSDCRRPGETQVVAVLGKAGQGKSHWARTVSHTWACGQLLQYDFVFYVPCHCLDRPGDTYHLRDLLCPPSLQPLAMDDEVLDYIVRQPDRVLLILDAFEELEAQDGLLHGPCGSLSPEPCSLRGLLAGIFQRKLLRGCTLLLTARPRGRLAQSLSKADAIFEVPSFSTKQAKTYMRHYFENSGTAGNQDKALGLLEGQPLLCSYSHSPVVCRAVCQLSKALLEQGTEAQLPCTLTGLYVSLLGPAAQNSPPGALVELAKLAWELGRRHQSTLQETRFSSVEVKTWAVTQGLMQQTLETTEAQLAFSSFLLQCFLGAVWLAQCNEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLVFQPRAHCLGALVEPAVAAVADRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQPGIWEHVAHQLPGHLSFLGTRLTPPDVYVLGRALETASQDFSLDLRQTGVEPSGLGNLVGLSCVTSFRASLSDTMALWESLQQQGEAQLLQAAEEKFTIEPFKAKSPKDVEDLDRLVQTQRLRNPSEDAAKDLPAIRDLKKLEFALGPILGPQAFPTLAKILPAFSSLQHLDLDSLSENKIGDKGVSKLSATFPQLKALETLNLSQNNITDVGACKLAEALPALAKSLLRLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKCPQVETLAMWTPTIPFGVQEHLQQLDARISLR
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter (PubMed:37327784). Does not bind DNA (By similarity). May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both (By similarity). Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (By similarity). Also mediates enhanced MHC class I transcription, the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes (By similarity). Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity (By similarity). Exhibits serine/threonine protein kinase activity: phosphorylates the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (By similarity). {ECO:0000250|UniProtKB:P33076, ECO:0000269|PubMed:32855215, ECO:0000269|PubMed:37327784}.
uniprot
proteins
mass_dalton
127528
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated, affecting interaction with TAF7. {ECO:0000250|UniProtKB:P33076}.
uniprot
proteins
pubmed
32855215
uniprot
proteins
pubmed
37327784
uniprot
proteins
pubmed
8620527
uniprot
proteins
pubmed
8995190
uniprot
proteins
pubmed
9184229
uniprot
proteins
sequence_length
1155
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P33076}. Nucleus, PML body {ECO:0000250|UniProtKB:P33076}. Note=Recruited to PML body by PML. {ECO:0000250|UniProtKB:P33076}.
uniprot
proteins