Atg10
entrez
66795
canonical
uniprot
Q8R1P4
canonical
ensembl
ENSMUSG00000021619
resolver
ensp
ENSMUSP00000022119
resolver
ensp
ENSMUSP00000172556
resolver
ensp
ENSMUSP00000172558
resolver
ensp
ENSMUSP00000172560
resolver
ensp
ENSMUSP00000172573
resolver
ensp
ENSMUSP00000172576
resolver
enst
ENSMUST00000022119
resolver
genesymbol
Atg10
resolver
genesymbol_syn
Apg10l
resolver
uniprot
A0A0R4J029
resolver
uniprot
Q8BPA9
resolver
uniprot
Q9D3J7
resolver
uniprot_entry
A0A0R4J029_MOUSE
resolver
uniprot_entry
ATG10_MOUSE
resolver
uniprot_sec
Q8BPA9
resolver
uniprot_sec
Q9D3J7
resolver
amino_acid_sequence
MEDEFFGEKSFQHYCAEFIRHSQQIGDGWEWRTAKECSDGYMCKTQFRIKNEASTPHVGTPASVLTCLPTEENLELPMDDSEVTRPAAVAEVIKHEYHVLYSCSYQVPVLYFRASFLDGRPLALEDIWEGVHECYKPRLLQGPWDTITQQEHPILGQPFFVLHPCKTNEFMTAVLKNSQKINRNVNYITSWLSLVGPVVGLNLPLSYAKATSQSE
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
function
FUNCTION: E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3. Plays a role in adenovirus-mediated cell lysis. {ECO:0000269|PubMed:12890687, ECO:0000269|PubMed:20723759, ECO:0000269|PubMed:21367888}.
uniprot
proteins
mass_dalton
24577
uniprot
proteins
mutagenesis
MUTAGEN 165; /note="C->S: Instead of the formation of an intermediate complex with a thiol ester bond between ATG10 (E2-like enzyme) and ATG12 (substrate), a stable complex with an O-ester bond is formed. Does not affect ATG12 conjugation to ATG3."; /evidence="ECO:0000269|PubMed:12482611, ECO:0000269|PubMed:12890687, ECO:0000269|PubMed:20723759
uniprot
proteins
protein_family
ATG10 family
uniprot
proteins
pubmed
12482611
uniprot
proteins
pubmed
12890687
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20723759
uniprot
proteins
pubmed
21367888
uniprot
proteins
sequence_length
215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins