CLDN14
entrez
23562
canonical
uniprot
O95500
canonical
ensembl
ENSG00000159261
resolver
ensp
ENSP00000339292
resolver
ensp
ENSP00000382087
resolver
ensp
ENSP00000382088
resolver
ensp
ENSP00000382090
resolver
ensp
ENSP00000382092
resolver
ensp
ENSP00000547668
resolver
ensp
ENSP00000547669
resolver
ensp
ENSP00000547670
resolver
ensp
ENSP00000547671
resolver
ensp
ENSP00000547672
resolver
ensp
ENSP00000547673
resolver
ensp
ENSP00000547674
resolver
ensp
ENSP00000547675
resolver
ensp
ENSP00000547676
resolver
ensp
ENSP00000547677
resolver
ensp
ENSP00000547678
resolver
enst
ENST00000342108
resolver
enst
ENST00000399135
resolver
enst
ENST00000399136
resolver
enst
ENST00000399137
resolver
enst
ENST00000399139
resolver
enst
ENST00000877609
resolver
enst
ENST00000877610
resolver
enst
ENST00000877611
resolver
enst
ENST00000877612
resolver
enst
ENST00000877613
resolver
enst
ENST00000877614
resolver
enst
ENST00000877615
resolver
enst
ENST00000877616
resolver
enst
ENST00000877617
resolver
enst
ENST00000877618
resolver
enst
ENST00000877619
resolver
genesymbol
CLDN14
resolver
hgnc
HGNC:2035
resolver
uniprot_entry
CLD14_HUMAN
resolver
amino_acid_sequence
MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAILGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQDEAPYRPYQAPPRATTTTANTAPAYQPPAAYKDNRAPSVTSATHSGYRLNDYV
uniprot
proteins
disease_involvement
DISEASE: Deafness, autosomal recessive, 29 (DFNB29) [MIM:614035]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269|PubMed:11163249, ECO:0000269|PubMed:22246673, ECO:0000269|PubMed:23235333}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.
uniprot
proteins
mass_dalton
25699
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
11163249
uniprot
proteins
pubmed
12791041
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22246673
uniprot
proteins
pubmed
23235333
uniprot
proteins
pubmed
23590985
uniprot
proteins
sequence_length
239
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins