ADORA3
entrez
140
canonical
uniprot
P0DMS8
canonical
ensembl
ENSG00000282608
resolver
ensp
ENSP00000241356
resolver
ensp
ENSP00000488073
resolver
enst
ENST00000241356
resolver
enst
ENST00000632535
resolver
genesymbol
ADORA3
resolver
hgnc
HGNC:268
resolver
uniprot
A0A0J9YWR0
resolver
uniprot
A2A3P4
resolver
uniprot
H6VQ59
resolver
uniprot
P33765
resolver
uniprot
Q6UWU0
resolver
uniprot
Q9BYZ1
resolver
uniprot_entry
A0A0J9YWR0_HUMAN
resolver
uniprot_entry
AA3R_HUMAN
resolver
uniprot_entry
H6VQ59_HUMAN
resolver
uniprot_sec
A2A3P4
resolver
uniprot_sec
P33765
resolver
uniprot_sec
Q6UWU0
resolver
uniprot_sec
Q9BYZ1
resolver
amino_acid_sequence
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
uniprot
proteins
function
FUNCTION: G protein-coupled receptor (GPCR) for adenosine that plays significant roles in various physiological processes including immune regulation, cardioprotection and neuroprotection (PubMed:38627384, PubMed:40825947, PubMed:9837869). Also acts as a receptor for adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification, which are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs): activated by N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A) (PubMed:33472058, PubMed:39511145). Preferentially couples to the inhibitory G protein (Gi), leading to the suppression of adenylate cyclase activity and a reduction in intracellular cyclic AMP levels (PubMed:33472058, PubMed:38627384). Upon adenosine binding, mediates cardioprotection in cardiomyocytes through anti-apoptotic effects primarily via the ERK1/2 pathway as well as the PI3K pathway (PubMed:9837869). In the central nervous system, participates in the modulation of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus (By similarity). In lung mast cells, receptor activation contributes to the type I allergic response by facilitating mast cell degranulation and histamine release (By similarity). Highly expressed in inflammatory cells such as neutrophils and mast cells, inhibits neutrophil degranulation and reduces superoxide production, thereby modulating inflammatory responses (PubMed:9164961). {ECO:0000250|UniProtKB:P28647, ECO:0000250|UniProtKB:Q61618, ECO:0000269|PubMed:33472058, ECO:0000269|PubMed:38627384, ECO:0000269|PubMed:39511145, ECO:0000269|PubMed:40825947, ECO:0000269|PubMed:9164961, ECO:0000269|PubMed:9837869}.; FUNCTION: [Isoform 2]: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (PubMed:8234299). {ECO:0000269|PubMed:8234299}.
uniprot
proteins
mass_dalton
36185
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="Y->A: Abolished receptor activation upon ligand binding."; /evidence="ECO:0000269|PubMed:38627384, ECO:0000269|PubMed:40825947"; MUTAGEN 73; /note="S->A: Slightly decreased activation by adenosine."; /evidence="ECO:0000269|PubMed:40825947"; MUTAGEN 95; /note="H->A,F: Decreased activation by adenosine."; /evidence="ECO:0000269|PubMed:40825947"; MUTAGEN 169; /note="V->E: Abolished activation by adenosine and N(6)-methyladenosine (m6A)."; /evidence="ECO:0000269|PubMed:33472058"; MUTAGEN 169; /note="V->F,N: Strongly decreased activation by adenosines containing N(6)-methylated adenine (m6A)."; /evidence="ECO:0000269|PubMed:39511145"; MUTAGEN 181; /note="S->N: Abolished receptor activation upon ligand binding."; /evidence="ECO:0000269|PubMed:38627384"; MUTAGEN 247; /note="S->N: Abolished receptor activation upon ligand binding."; /evidence="ECO:0000269|PubMed:38627384"; MUTAGEN 253; /note="I->T,N,Q: Decreased activation by N(6)-methyladenosine (m6A)."; /evidence="ECO:0000269|PubMed:33472058, ECO:0000269|PubMed:39511145"; MUTAGEN 264; /note="L->M: Decreased activation by N(6)-methyladenosine (m6A)."; /evidence="ECO:0000269|PubMed:33472058"; MUTAGEN 265; /note="Y->A: Slightly decreased activation by adenosine."; /evidence="ECO:0000269|PubMed:40825947"; MUTAGEN 271; /note="S->A: Decreased activation by adenosine."; /evidence="ECO:0000269|PubMed:40825947
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11214319
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
27886186
uniprot
proteins
pubmed
33472058
uniprot
proteins
pubmed
38627384
uniprot
proteins
pubmed
39511145
uniprot
proteins
pubmed
40825947
uniprot
proteins
pubmed
8234299
uniprot
proteins
pubmed
8399349
uniprot
proteins
pubmed
9164961
uniprot
proteins
pubmed
9837869
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q28309}; Multi-pass membrane protein {ECO:0000269|PubMed:38627384, ECO:0000269|PubMed:40825947}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..38; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:38627384, ECO:0000269|PubMed:40825947, ECO:0007744|PDB:8X16, ECO:0007744|PDB:8X17, ECO:0007744|PDB:9EBH, ECO:0007744|PDB:9EBI, ECO:0007744|PDB:9EHS"; TRANSMEM 47..69; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:38627384, ECO:0000269|PubMed:40825947, ECO:0007744|PDB:8X16, ECO:0007744|PDB:8X17, ECO:0007744|PDB:9EBH, ECO:0007744|PDB:9EBI, ECO:0007744|PDB:9EHS"; TRANSMEM 84..106; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:38627384, ECO:0000269|PubMed:40825947, ECO:0007744|PDB:8X16, ECO:0007744|PDB:8X17, ECO:0007744|PDB:9EBH, ECO:0007744|PDB:9EBI, ECO:0007744|PDB:9EHS"; TRANSMEM 127..149; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:38627384, ECO:0000269|PubMed:40825947, ECO:0007744|PDB:8X16, ECO:0007744|PDB:8X17, ECO:0007744|PDB:9EBH, ECO:0007744|PDB:9EBI, ECO:0007744|PDB:9EHS"; TRANSMEM 172..197; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:38627384, ECO:0000269|PubMed:40825947, ECO:0007744|PDB:8X16, ECO:0007744|PDB:8X17, ECO:0007744|PDB:9EBH, ECO:0007744|PDB:9EBI, ECO:0007744|PDB:9EHS"; TRANSMEM 229..254; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:38627384, ECO:0000269|PubMed:40825947, ECO:0007744|PDB:8X16, ECO:0007744|PDB:8X17, ECO:0007744|PDB:9EBH, ECO:0007744|PDB:9EBI, ECO:0007744|PDB:9EHS"; TRANSMEM 263..284; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:38627384, ECO:0000269|PubMed:40825947, ECO:0007744|PDB:8X16, ECO:0007744|PDB:8X17, ECO:0007744|PDB:9EBH, ECO:0007744|PDB:9EBI, ECO:0007744|PDB:9EHS
uniprot
proteins