Fbxo43
entrez
315034
canonical
uniprot
Q66H04
canonical
ensembl
ENSRNOG00000010459
resolver
ensembl
ENSRNOG00055027285
resolver
ensembl
ENSRNOG00060009928
resolver
ensembl
ENSRNOG00065016081
resolver
ensp
ENSRNOP00000014333
resolver
ensp
ENSRNOP00055038821
resolver
ensp
ENSRNOP00060013116
resolver
ensp
ENSRNOP00065020978
resolver
enst
ENSRNOT00000014333
resolver
enst
ENSRNOT00055047208
resolver
enst
ENSRNOT00060016771
resolver
enst
ENSRNOT00065026731
resolver
genesymbol
Fbxo43
resolver
genesymbol_syn
Emi2
resolver
uniprot_entry
FBX43_RAT
resolver
amino_acid_sequence
MPQKHSASHRAGSNMGSSAVTVRCPSLPDFGPTSSFKHRGPHELSETCSFSKKEKDPMLTCEHLETPRLGFPNPAVSPSPRKKSVSLRKEKEESPELCETPKLRRKKCTLRRRLDLTLTLLKGDSDSQSSSLESNISHSLSLEKRLRDSTSGFPKEDNFSPLVTSTVKTEDAISSSQNSRLHFSQHKTSTIDDSKDDCGLFEVECLSPIEGNDFKDSVTHFSDSGLSASDENTCPELLGSSGSQTTYGADVTTSVTPVSSLIAKIKFHGSQTLASSAEVRDSLSTPEDSGFCSLSWDKSEDFLSDQEGSFQELQKHRGTPTVGDLVRQPKHPGRLRRLPTLQEQGSQSETDDEMQVAHPSAGVRVGTASGVLESQQGSEEKSGDLTLSFKDLSNTPALQLVCELFMKSKRKRFEQADDQEFSEEREEGKIARLQHVLAGLIGKKMGIERLDILTELQYRNLKHILAMVLDSLTAESLYSAWNVSRNWRGIVAQDKRANRRRKLFIAQLKAKAQGAAVLRVQDAATRLRLLSRLALRSVQAQAQAPNGQNEQAPAQSPWGEVLTPVASSSLTHLRSKQEQYLKVARTLFTDEALKPCPRCQSPAKYQPHKKRGLCSRLACGFDFCVLCLCAYHGSEDCRRGSAKGRGSRDVLPGSAQSKRNLKRL
uniprot
proteins
function
FUNCTION: Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (By similarity). Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis. {ECO:0000250|UniProtKB:Q4G163}.
uniprot
proteins
mass_dalton
73228
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Thr-190 and Ser-289 in response to calcium, which is a prerequisite for ubiquitination and proteasomal degradation. {ECO:0000250}.; PTM: Ubiquitinated in response to calcium, which promotes proteasomal degradation. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
664
uniprot
proteins