Fusion of virus membrane with host cell membrane
uniprot_keyword
KW-1169
canonical
name
Fusion of virus membrane with host cell membrane
uniprot
synonym
Viral entry into host cell via plasma membrane fusion
uniprot
definition
Viral protein involved in the merging of the virus envelope with host cytoplasmic membrane during viral penetration into host cell. Virus fusion proteins drive this fusion reaction by undergoing a major conformational change that is triggered by interactions with the target cell. This pathway is used by viruses whose fusion protein is usually pH independent such as most paramyxoviruses, herpesviruses and retroviruses. MHV-JHM coronavirus has been shown to fuse directly with the host cytoplasmic membrane. Prokaryotic viruses such as Tectiviridae fuse their inner membrane with the host cytoplasmic membrane whereas Cystoviridae fuse their outer membrane with the host cytoplasmic membrane.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
uniprot_keywords
uniprot
keywords