Nek8
entrez
287473
canonical
uniprot
D3ZGQ5
canonical
ensembl
ENSRNOG00000012866
resolver
ensembl
ENSRNOG00055029257
resolver
ensembl
ENSRNOG00060027550
resolver
ensembl
ENSRNOG00065022679
resolver
ensp
ENSRNOP00000017264
resolver
ensp
ENSRNOP00000079841
resolver
ensp
ENSRNOP00055041810
resolver
ensp
ENSRNOP00060039810
resolver
ensp
ENSRNOP00065031463
resolver
enst
ENSRNOT00055050735
resolver
enst
ENSRNOT00060047863
resolver
enst
ENSRNOT00065038793
resolver
genesymbol
Nek8
resolver
genesymbol_syn
Jck
resolver
uniprot_entry
NEK8_RAT
resolver
amino_acid_sequence
MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNIHTDVGSVRMRRAEKCLTPGTPMAPGSTGSRATSARCRGVPRGPVRPAIPPPLSSVYAWGGGLSIPLRLPMPNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGTGGGTLLPGAVELPQPQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSADGELFAWGRGDGGRLGLGTRESHNCPQQVPMVPGQEAQRVVCGIDCSMILTSPGRVLACGSNRFNKLGLDCLSLEEEPVPHQQVEEALSFTPLGSAPLDRETLLCVDLGTAHSAAVTASGACYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTVAIGAEGEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSCCHGNTLLAVRSVTDEPVPP
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q91ZR4}.
uniprot
proteins
mass_dalton
75254
uniprot
proteins
protein_family
NEK Ser/Thr protein kinase family
uniprot
proteins
protein_family
NIMA subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
23793029
uniprot
proteins
sequence_length
698
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q91ZR4}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91ZR4}. Cell projection, cilium {ECO:0000250|UniProtKB:Q91ZR4}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q86SG6}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q86SG6}. Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells (By similarity). {ECO:0000250|UniProtKB:Q91ZR4}.
uniprot
proteins