Eps8l2
entrez
98845
canonical
uniprot
Q99K30
canonical
ensembl
ENSMUSG00000025504
resolver
ensp
ENSMUSP00000026577
resolver
genesymbol
Eps8l2
resolver
genesymbol_syn
Eps8r2
resolver
uniprot
Q91VT7
resolver
uniprot_entry
ES8L2_MOUSE
resolver
uniprot_sec
Q91VT7
resolver
amino_acid_sequence
MSQSASMSCCPGAANGSLGRSDGVPRMSAKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAIASVDDAIRKLVQLSSKEKVWAQEVLLQVNDKSLRLLDVESQEELENFPLPTVQHSQTVLNQLRYPSVLLLVCQDSDQNKPDIHFFHCDEVEAELVQEDIESALADYRLGKKMRPQTLKGHQEKIRQRQSILPPPQSPAPIPFQRQPGDSPQAKNRVGLPLPVPFSEPGYRRRESQDEEPRAVLAQRIEKETQILNCTLDDIEWFVARLQKAAEAFKQLNQRKKGKKKNKKGPAEGVLTLRARPPSEGEFVDCFQKTKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIINTCGSPDIARSVSSPLLSTDAVSFLRGHLVPKEMTLWESLGETWMRPRSEWPREPQVPLYVPKFRSGWEPPLDVLQEAPWEVEGLASVPSDQLTPKNRLSVRHSPKHSLSSESQAPEDIAPPGSSPHANRGYQPTPAMTKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRNRSGQAGYVPCNILAEARQEDVGAPLEQSGQKYWGPASPTHKLPPIFAGNKEELIHHMDEVNDELMKKISHIKTQPQRNFRVERSQPVHLPLTFESGPDEVRAWLEAKAFSARIVENLGILTGPQLFSLNKEELKKVCGEEGSRVYSQLTVQKAFLEKQQSGSELEKLMSKIRRAEDSYTSQHTSPESEGAPHL
uniprot
proteins
function
FUNCTION: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). In the cochlea, is required for stereocilia maintenance in adult hair cells (PubMed:23918390). {ECO:0000250|UniProtKB:Q9H6S3, ECO:0000269|PubMed:23918390}.
uniprot
proteins
mass_dalton
82229
uniprot
proteins
protein_family
EPS8 family
uniprot
proteins
pubmed
14565974
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23918390
uniprot
proteins
sequence_length
729
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H6S3}. Cell projection, stereocilium {ECO:0000269|PubMed:23918390}. Note=Localizes at the tips of the stereocilia of the inner and outer hair cells. {ECO:0000269|PubMed:23918390}.
uniprot
proteins