Mybl1
entrez
17864
canonical
uniprot
P51960
canonical
ensembl
ENSMUSG00000025912
resolver
ensp
ENSMUSP00000086034
resolver
ensp
ENSMUSP00000111128
resolver
enst
ENSMUST00000088658
resolver
enst
ENSMUST00000115468
resolver
genesymbol
Mybl1
resolver
genesymbol_syn
Amyb
resolver
uniprot
A0A0R4J132
resolver
uniprot
E9QLX9
resolver
uniprot_entry
A0A0R4J132_MOUSE
resolver
uniprot_entry
E9QLX9_MOUSE
resolver
uniprot_entry
MYBA_MOUSE
resolver
amino_acid_sequence
MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCATMDHLQTQNQFYIPVQIPGYQYVSPDGNCVEHVQTSAFIQQPFVDEDPDKEKKIKELELLLMSAENEVRRKRLPPQPGSFSSWSGSFLMDDSMSNTLNNLEEHTTEFYSMDENQTVSAQQNSPTKFLAVEANAVLSSLQTIPEFPRTLELIESDPVAWSDVTSFDLSDAAASPVKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNSRNGGDSEAIPLTSPNVVKFSTPPTISRKKKRIRVGQSAGSELGSASLSEVGNRRIKHTPVKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKVLITTPLQKEATPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDIFLKEEDEPAYKSCKQEHSASVKKVRKSLALESWDKEEPGTQLLTEDISDMQSENILTTSLLMIPLLEIHDNRCNLTPEKQDINSANKTYTLNKKRPNPNPCKAVKLEKSLQSNCEWETVVYGKTEDQLIMTEQARRYLSTYTATSSTSRALIL
uniprot
proteins
function
FUNCTION: Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:23523368, PubMed:7813437). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism, such as PIWIL1 (PubMed:21750041, PubMed:23523368). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (PubMed:23523368). Transcriptional activator of SOX30 (PubMed:29848638). {ECO:0000269|PubMed:21750041, ECO:0000269|PubMed:23523368, ECO:0000269|PubMed:29848638, ECO:0000269|PubMed:7813437}.
uniprot
proteins
mass_dalton
85728
uniprot
proteins
mutagenesis
MUTAGEN 213; /note="A->E: In Repro9; male sterility due to defects in spermatogenesis. Impaired piRNA biogenesis."; /evidence="ECO:0000269|PubMed:21750041, ECO:0000269|PubMed:23523368
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21750041
uniprot
proteins
pubmed
23523368
uniprot
proteins
pubmed
29848638
uniprot
proteins
pubmed
7813437
uniprot
proteins
pubmed
8084617
uniprot
proteins
sequence_length
751
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21750041}.
uniprot
proteins