Tle3
entrez
84424
canonical
uniprot
Q9JIT3
canonical
ensembl
ENSRNOG00000013013
resolver
ensp
ENSRNOP00000018467
resolver
ensp
ENSRNOP00000079710
resolver
ensp
ENSRNOP00000109823
resolver
enst
ENSRNOT00000108424
resolver
enst
ENSRNOT00000164911
resolver
genesymbol
Tle3
resolver
genesymbol_syn
Esp3
resolver
uniprot
A0A8I5ZNN2
resolver
uniprot
A0ABK0M505
resolver
uniprot_entry
A0A8I5ZNN2_RAT
resolver
uniprot_entry
A0ABK0M505_RAT
resolver
uniprot_entry
TLE3_RAT
resolver
amino_acid_sequence
MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKPPGMDPIASALRTPISLTSSYAAPFAMMSHHEMNGSLTSPSAYAGLHNIPSQMSAAAAAAAAAYGRSPMVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY
uniprot
proteins
function
FUNCTION: Transcriptional coregulator that binds to a number of transcription factors. Acts as a regulator of adipogenesis both by acting as a corepressor of Wnt signaling and coactivator for PPARG (By similarity). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (By similarity). Promotes diffentiation of white adipocytes by acting as a coactivator for PPARG and preventing the association between PRDM16 and PPARG, thereby preventing browning of white adipocytes (By similarity). {ECO:0000250|UniProtKB:Q04726, ECO:0000250|UniProtKB:Q08122}.
uniprot
proteins
mass_dalton
82644
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4. Ubiquitinated at Lys-712 by UBR5 in response to Wnt signaling, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome. {ECO:0000250|UniProtKB:Q04726}.
uniprot
proteins
protein_family
WD repeat Groucho/TLE family
uniprot
proteins
pubmed
10800926
uniprot
proteins
pubmed
18254933
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
764
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q08122}. Chromosome {ECO:0000250|UniProtKB:Q08122}. Note=Localizes to chromatin. {ECO:0000250|UniProtKB:Q08122}.
uniprot
proteins