Ptn
entrez
19242
canonical
uniprot
P63089
canonical
ensembl
ENSMUSG00000029838
resolver
ensp
ENSMUSP00000099073
resolver
ensp
ENSMUSP00000286003
resolver
enst
ENSMUST00000101534
resolver
genesymbol
Ptn
resolver
uniprot
P20935
resolver
uniprot_entry
PTN_MOUSE
resolver
uniprot_sec
P20935
resolver
amino_acid_sequence
MSSQQYQQQRRKFAAAFLALIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSGDCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGSLKRALHNADCQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD
uniprot
proteins
function
FUNCTION: Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (By similarity). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (PubMed:15121180, PubMed:19442624, PubMed:27445335, PubMed:30497772). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (PubMed:11414790, PubMed:25000129). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK or AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:27445335). Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:27445335). Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (By similarity). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (PubMed:30497772). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion (By similarity). Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (By similarity). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (By similarity). Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway (PubMed:15121180). Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration (PubMed:21791434). In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway (PubMed:16619002, PubMed:17121547, PubMed:28657144). {ECO:0000250|UniProtKB:P21246, ECO:0000250|UniProtKB:P63090, ECO:0000269|PubMed:11414790, ECO:0000269|PubMed:15121180, ECO:0000269|PubMed:16619002, ECO:0000269|PubMed:17121547, ECO:0000269|PubMed:19442624, ECO:0000269|PubMed:21791434, ECO:0000269|PubMed:25000129, ECO:0000269|PubMed:27445335, ECO:0000269|PubMed:28657144, ECO:0000269|PubMed:30497772}.
uniprot
proteins
mass_dalton
18869
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NEK6. {ECO:0000250|UniProtKB:P21246}.
uniprot
proteins
protein_family
Pleiotrophin family
uniprot
proteins
pubmed
11414790
uniprot
proteins
pubmed
12093164
uniprot
proteins
pubmed
1457042
uniprot
proteins
pubmed
15121180
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1550576
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16619002
uniprot
proteins
pubmed
1701634
uniprot
proteins
pubmed
17121547
uniprot
proteins
pubmed
1768439
uniprot
proteins
pubmed
19442624
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21791434
uniprot
proteins
pubmed
25000129
uniprot
proteins
pubmed
27445335
uniprot
proteins
pubmed
28657144
uniprot
proteins
pubmed
30497772
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P21246}.
uniprot
proteins