FZD1
entrez
8321
canonical
uniprot
Q9UP38
canonical
ensembl
ENSG00000157240
resolver
ensp
ENSP00000287934
resolver
enst
ENST00000287934
resolver
genesymbol
FZD1
resolver
hgnc
HGNC:4038
resolver
uniprot
A4D1E8
resolver
uniprot
O94815
resolver
uniprot
Q549T8
resolver
uniprot_entry
FZD1_HUMAN
resolver
uniprot_sec
A4D1E8
resolver
uniprot_sec
O94815
resolver
uniprot_sec
Q549T8
resolver
amino_acid_sequence
MAEEEAPKKSRAAGGGASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLWLLEAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins (PubMed:10557084). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084). Contradictory results showing activation by WNT7B have been described for mouse (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). {ECO:0000250|UniProtKB:O70421, ECO:0000269|PubMed:10557084, ECO:0000305}.; FUNCTION: (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium. {ECO:0000269|PubMed:27680706}.
uniprot
proteins
mass_dalton
71158
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
10557084
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19188438
uniprot
proteins
pubmed
27680706
uniprot
proteins
pubmed
9707618
uniprot
proteins
pubmed
9813155
uniprot
proteins
sequence_length
647
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10557084}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 323..343; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 355..375; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 403..423; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 446..466; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 490..510; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 537..557; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 602..622; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins