Pla2g2d
entrez
18782
canonical
uniprot
Q9WVF6
canonical
ensembl
ENSMUSG00000041202
resolver
ensp
ENSMUSP00000030528
resolver
ensp
ENSMUSP00000101432
resolver
genesymbol
Pla2g2d
resolver
genesymbol_syn
Pla2a2
resolver
genesymbol_syn
Splash
resolver
uniprot
Q3TYT9
resolver
uniprot
Q3V4B8
resolver
uniprot
Q9JLK0
resolver
uniprot_entry
PA2GD_MOUSE
resolver
uniprot_entry
Q3TYT9_MOUSE
resolver
uniprot_sec
Q3V4B8
resolver
uniprot_sec
Q9JLK0
resolver
amino_acid_sequence
MRLALLCGLLLAGITATQGGLLNLNKMVTHMTGKKAFFSYWPYGCHCGLGGKGQPKDATDWCCQKHDCCYAHLKIDGCKSLTDNYKYSISQGTIQCSDNGSWCERQLCACDKEVALCLKQNLDSYNKRLRYYWRPRCKGKTPAC
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions (PubMed:10455175, PubMed:10531313, PubMed:23690440, PubMed:26392224). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity). In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins (PubMed:23690440). During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response (PubMed:23690440, PubMed:27226632). May act in an autocrine and paracrine manner. Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance (PubMed:19564598). May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). {ECO:0000250|UniProtKB:Q9UNK4, ECO:0000269|PubMed:10455175, ECO:0000269|PubMed:10531313, ECO:0000269|PubMed:11694541, ECO:0000269|PubMed:19564598, ECO:0000269|PubMed:23690440, ECO:0000269|PubMed:26392224, ECO:0000269|PubMed:27226632}.
uniprot
proteins
mass_dalton
16164
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="H->A: Has no effect on Treg effector functions."; /evidence="ECO:0000269|PubMed:19564598
uniprot
proteins
protein_family
Phospholipase A2 family
uniprot
proteins
pubmed
10383420
uniprot
proteins
pubmed
10455175
uniprot
proteins
pubmed
10531313
uniprot
proteins
pubmed
11196711
uniprot
proteins
pubmed
11694541
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19564598
uniprot
proteins
pubmed
23690440
uniprot
proteins
pubmed
26392224
uniprot
proteins
pubmed
27226632
uniprot
proteins
sequence_length
144
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000269|PubMed:10455175}. Cell membrane {ECO:0000269|PubMed:19564598}. Note=Localizes to cell membrane likely through binding to heparan sulfate proteoglycans. {ECO:0000269|PubMed:19564598}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}.
uniprot
proteins