GTF2H3
entrez
2967
canonical
uniprot
Q13889
canonical
ensembl
ENSG00000111358
resolver
ensp
ENSP00000228955
resolver
ensp
ENSP00000441894
resolver
ensp
ENSP00000445162
resolver
ensp
ENSP00000481711
resolver
enst
ENST00000618160
resolver
genesymbol
GTF2H3
resolver
hgnc
HGNC:4657
resolver
uniprot
A0A087WYD5
resolver
uniprot
B2R819
resolver
uniprot
B4DNZ6
resolver
uniprot
Q7L0G0
resolver
uniprot
Q96AT7
resolver
uniprot_entry
A0A087WYD5_HUMAN
resolver
uniprot_entry
TF2H3_HUMAN
resolver
uniprot_sec
B2R819
resolver
uniprot_sec
B4DNZ6
resolver
uniprot_sec
Q7L0G0
resolver
uniprot_sec
Q96AT7
resolver
amino_acid_sequence
MVSDEDELNLLVIVVDANPIWWGKQALKESQFTLSKCIDAVMVLGNSHLFMNRSNKLAVIASHIQESRFLYPGKNGRLGDFFGDPGNPPEFNPSGSKDGKYELLTSANEVIVEEIKDLMTKSDIKGQHTETLLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMNVIFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQLILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAKKKKLKVSA
uniprot
proteins
function
FUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:9852112}.
uniprot
proteins
mass_dalton
34378
uniprot
proteins
protein_family
TFB4 family
uniprot
proteins
pubmed
10024882
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
27193682
uniprot
proteins
pubmed
31253769
uniprot
proteins
pubmed
33902107
uniprot
proteins
pubmed
8194529
uniprot
proteins
pubmed
9852112
uniprot
proteins
sequence_length
308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:9852112}.
uniprot
proteins