ACSL5
entrez
51703
canonical
uniprot
Q9ULC5
canonical
ensembl
ENSG00000197142
resolver
ensp
ENSP00000346680
resolver
ensp
ENSP00000348429
resolver
ensp
ENSP00000376796
resolver
ensp
ENSP00000403647
resolver
enst
ENST00000433418
resolver
genesymbol
ACSL5
resolver
genesymbol_syn
ACS5
resolver
genesymbol_syn
FACL5
resolver
hgnc
HGNC:16526
resolver
uniprot
A0A8C8L3F5
resolver
uniprot
A6GV77
resolver
uniprot
D3DRB3
resolver
uniprot
Q6UX44
resolver
uniprot
Q9UIU4
resolver
uniprot_entry
A0A8C8L3F5_HUMAN
resolver
uniprot_entry
ACSL5_HUMAN
resolver
uniprot_sec
A6GV77
resolver
uniprot_sec
D3DRB3
resolver
uniprot_sec
Q6UX44
resolver
uniprot_sec
Q9UIU4
resolver
amino_acid_sequence
MLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIEGGARKGVSQKNNDLTSCCFSDAKTMYEVFQRGLAVSDNGPCLGYRKPNQPYRWLSYKQVSDRAEYLGSCLLHKGYKSSPDQFVGIFAQNRPEWIISELACYTYSMVAVPLYDTLGPEAIVHIVNKADIAMVICDTPQKALVLIGNVEKGFTPSLKVIILMDPFDDDLKQRGEKSGIEILSLYDAENLGKEHFRKPVPPSPEDLSVICFTSGTTGDPKGAMITHQNIVSNAAAFLKCVEHAYEPTPDDVAISYLPLAHMFERIVQAVVYSCGARVGFFQGDIRLLADDMKTLKPTLFPAVPRLLNRIYDKVQNEAKTPLKKFLLKLAVSSKFKELQKGIIRHDSFWDKLIFAKIQDSLGGRVRVIVTGAAPMSTSVMTFFRAAMGCQVYEAYGQTECTGGCTFTLPGDWTSGHVGVPLACNYVKLEDVADMNYFTVNNEGEVCIKGTNVFKGYLKDPEKTQEALDSDGWLHTGDIGRWLPNGTLKIIDRKKNIFKLAQGEYIAPEKIENIYNRSQPVLQIFVHGESLRSSLVGVVVPDTDVLPSFAAKLGVKGSFEELCQNQVVREAILEDLQKIGKESGLKTFEQVKAIFLHPEPFSIENGLLTPTLKAKRGELSKYFRTQIDSLYEHIQD
uniprot
proteins
disease_involvement
DISEASE: Diarrhea 13 (DIAR13) [MIM:620357]: An autosomal recessive disorder characterized by neonatal onset of recurrent vomiting and diarrhea, leading to severe failure to thrive. {ECO:0000269|PubMed:33191500}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
6.2.1.15
uniprot
proteins
ec_number
6.2.1.3
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:22633490, PubMed:24269233, PubMed:33191500). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. {ECO:0000250, ECO:0000269|PubMed:17681178, ECO:0000269|PubMed:18806831, ECO:0000269|PubMed:19459852, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233, ECO:0000269|PubMed:33191500}.
uniprot
proteins
mass_dalton
75991
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17681178
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18806831
uniprot
proteins
pubmed
19459852
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22633490
uniprot
proteins
pubmed
24269233
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
33191500
uniprot
proteins
sequence_length
683
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:17681178, ECO:0000269|PubMed:33191500}. Endoplasmic reticulum {ECO:0000269|PubMed:17681178, ECO:0000269|PubMed:24269233, ECO:0000269|PubMed:33191500}. Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:24269233}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins