Pear1
entrez
73182
canonical
uniprot
Q8VIK5
canonical
ensembl
ENSMUSG00000028073
resolver
ensp
ENSMUSP00000078090
resolver
ensp
ENSMUSP00000133323
resolver
ensp
ENSMUSP00000133474
resolver
ensp
ENSMUSP00000208107
resolver
genesymbol
Pear1
resolver
genesymbol_syn
Jedi
resolver
genesymbol_syn
Megf12
resolver
uniprot
Q3URX7
resolver
uniprot
Q6KAQ6
resolver
uniprot
Q8CGA7
resolver
uniprot
Q8VHF4
resolver
uniprot
Q8VHL7
resolver
uniprot
Q9CXP0
resolver
uniprot_entry
PEAR1_MOUSE
resolver
uniprot_entry
Q9CXP0_MOUSE
resolver
uniprot_sec
Q3URX7
resolver
uniprot_sec
Q6KAQ6
resolver
uniprot_sec
Q8CGA7
resolver
uniprot_sec
Q8VHF4
resolver
uniprot_sec
Q8VHL7
resolver
amino_acid_sequence
MPLCPLLLLALGLRLTGTLNSNDPNVCTFWESFTTTTKESHLRPFSLLPAESCHRPWEDPHTCAQPTVVYRTVYRQVVKMDSRPRLQCCRGYYESRGACVPLCAQECVHGRCVAPNQCQCAPGWRGGDCSSECAPGMWGPQCDKFCHCGNNSSCDPKSGTCFCPSGLQPPNCLQPCPAGHYGPACQFDCQCYGASCDPQDGACFCPPGRAGPSCNVPCSQGTDGFFCPRTYPCQNGGVPQGSQGSCSCPPGWMGVICSLPCPEGFHGPNCTQECRCHNGGLCDRFTGQCHCAPGYIGDRCQEECPVGRFGQDCAETCDCAPGARCFPANGACLCEHGFTGDRCTERLCPDGRYGLSCQEPCTCDPEHSLSCHPMHGECSCQPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGLCLADSGLCRCAPGYTGPHCANLCPPDTYGINCSSRCSCENAIACSPIDGTCICKEGWQRGNCSVPCPLGTWGFNCNASCQCAHDGVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASVCDCDHSDGCDPVHGQCRCQAGWMGTRCHLPCPEGFWGANCSNTCTCKNGGTCVSENGNCVCAPGFRGPSCQRPCPPGRYGKRCVQCKCNNNHSSCHPSDGTCSCLAGWTGPDCSEACPPGHWGLKCSQLCQCHHGGTCHPQDGSCICTPGWTGPNCLEGCPPRMFGVNCSQLCQCDLGEMCHPETGACVCPPGHSGADCKMGSQESFTIMPTSPVTHNSLGAVIGIAVLGTLVVALIALFIGYRQWQKGKEHEHLAVAYSTGRLDGSDYVMPDVSPSYSHYYSNPSYHTLSQCSPNPPPPNKVPGSQLFVSSQAPERPSRAHGRENHVTLPADWKHRREPHERGASHLDRSYSCSYSHRNGPGPFCHKGPISEEGLGASVMSLSSENPYATIRDLPSLPGEPRESGYVEMKGPPSVSPPRQSLHLRDRQQRQLQPQRDSGTYEQPSPLSHNEESLGSTPPLPPGLPPGHYDSPKNSHIPGHYDLPPVRHPPSPPSRRQDR
uniprot
proteins
function
FUNCTION: Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (PubMed:17226770). {ECO:0000269|PubMed:17226770, ECO:0000269|PubMed:36792666}.
uniprot
proteins
mass_dalton
110580
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in the intracellular domain on tyrosine residues (PubMed:17226770). Phosphorylated on tyrosine residues by SRC (By similarity). Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation (By similarity). Tyrosine phosphorylation enhanced its association with SHC1 and SHC2 (By similarity). Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated when in the presence of SVEP1 (By similarity). {ECO:0000250|UniProtKB:Q5VY43, ECO:0000269|PubMed:17226770}.
uniprot
proteins
protein_family
MEGF family
uniprot
proteins
pubmed
15449545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15851471
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17226770
uniprot
proteins
pubmed
36792666
uniprot
proteins
sequence_length
1034
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5VY43}; Single-pass membrane protein {ECO:0000255}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q5VY43}. Note=Detected on the cell surface in resting platelets. {ECO:0000250|UniProtKB:Q5VY43}.
uniprot
proteins
transmembrane_region
TRANSMEM 755..775; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins