Tbxas1
entrez
21391
canonical
uniprot
P36423
canonical
ensembl
ENSMUSG00000029925
resolver
ensp
ENSMUSP00000003017
resolver
ensp
ENSMUSP00000306026
resolver
ensp
ENSMUSP00000306027
resolver
ensp
ENSMUSP00000306029
resolver
enst
ENSMUST00000003017
resolver
genesymbol
Tbxas1
resolver
genesymbol_syn
Cyp5
resolver
genesymbol_syn
Cyp5a1
resolver
uniprot
P97505
resolver
uniprot
Q3UTF0
resolver
uniprot_entry
Q3UTF0_MOUSE
resolver
uniprot_entry
THAS_MOUSE
resolver
uniprot_sec
P97505
resolver
amino_acid_sequence
MEVLGLLKFEVSGTIVTVTLLVALLALLKWYSMSAFSRLEKLGIRHPKPSPFVGNLMFFRQGFWESQLELRERYGPLCGYYLGRRMHVVISEPDMIKQVLVENFSNFSNRMASGLEPKMVADSVLLLRDRRWEEVRGALMSSFSPEKLDEMTPLISQACELLVAHLKRYAASRDAFNIQRCYCCYTIDVVASVAFGTQVDSQNSPEDPFVQHCRRASTFCIPRPLLVLILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDQQAAEERRRDFLQMVLDAQHSMNSVGVEGFDMVPESLSSSECTKEPPQRCHPTSTSKPFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPAPEYHSLQEGLPYLDMVISETLRMYPPAFRFTREAAQDCEVLGQRIPAGTVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPETQVPLQLESKSALGPKNGVYIKIVSR
uniprot
proteins
ec_number
4.2.1.152
uniprot
proteins
ec_number
5.3.99.5
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE. {ECO:0000250|UniProtKB:P24557}.
uniprot
proteins
mass_dalton
60391
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
15010374
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7688225
uniprot
proteins
pubmed
9367676
uniprot
proteins
sequence_length
533
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P24557}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 76..96; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 336..356; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins