Cox19
entrez
68033
canonical
uniprot
Q8K0C8
canonical
ensembl
ENSMUSG00000045438
resolver
ensp
ENSMUSP00000062046
resolver
enst
ENSMUST00000049630
resolver
genesymbol
Cox19
resolver
uniprot_entry
COX19_MOUSE
resolver
amino_acid_sequence
MSTAMNFGTKSFQPRPPDKGSFPLDHFGECKSFKEKFMRCLRDKNYENALCRNESKEYLMCRMQRQLMAPEPLEKLGFRDLMEGKPEAKDEC
uniprot
proteins
function
FUNCTION: Assembly factor for cytochrome c oxidase (respiratory chain complex IV, CIV). Acts as a COX11 chaperone that supports COX11 copper coordination. Also stimulates SCO2-mediated metalation of COX2. Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis. In the absence of COX11, capable of stimulating copper delivery to the copper B site of COX1. {ECO:0000250|UniProtKB:Q49B96}.
uniprot
proteins
mass_dalton
10821
uniprot
proteins
protein_family
COX19 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23676665
uniprot
proteins
sequence_length
92
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q49B96}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q49B96}. Mitochondrion {ECO:0000250|UniProtKB:Q49B96}. Note=Partitions between mitochondria and the cytosol in a copper-dependent manner. Enriched in the cytosol when intracellular copper concentrations are elevated. {ECO:0000250|UniProtKB:Q49B96}.
uniprot
proteins