Acox1
entrez
11430
canonical
uniprot
Q9R0H0
canonical
ensembl
ENSMUSG00000020777
resolver
ensp
ENSMUSP00000063325
resolver
ensp
ENSMUSP00000072717
resolver
ensp
ENSMUSP00000122185
resolver
ensp
ENSMUSP00000321510
resolver
genesymbol
Acox1
resolver
genesymbol_syn
Acox
resolver
genesymbol_syn
Paox
resolver
uniprot
A2A850
resolver
uniprot
O35616
resolver
uniprot
Q3TDG0
resolver
uniprot
Q8BYC3
resolver
uniprot_entry
ACOX1_MOUSE
resolver
uniprot_sec
A2A850
resolver
uniprot_sec
O35616
resolver
uniprot_sec
Q3TDG0
resolver
uniprot_sec
Q8BYC3
resolver
amino_acid_sequence
MNPDLRKERAAATFNPELITHILDGSPENTRRRREIENLILNDPDFQHEDYNFLTRSQRYEVAVKKSATMVKKMREFGIADPEEIMWFKKLHMVNFVEPVGLNYSMFIPTLLNQGTTAQQEKWMHPSQELQIIGTYAQTEMGHGTHLRGLETTATYDPKTQEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITRGECYGLHAFVVPIREIGTHKPLPGITVGDIGPKFGYEEMDNGYLKMDNYRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGSAAQSLSKACTIAIRYSAVRRQSEIKRSEPEPQILDFQTQQYKLFPLLATAYAFHFLGRYIKETYMRINESIGQGDLSELPELHALTAGLKAFTTWTANAGIEECRMACGGHGYSHSSGIPNIYVTFTPACTFEGENTVMMLQTARFLMKIYDQVQSGKLVGGMVSYLNDLPSQRIQPQQVAVWPTLVDINSLDSLTEAYKLRAARLVEIAAKNLQAQVSHRKSKEVAWNLTSVDLVRASEAHCHYVTVKVFADKLPKIQDRAVQAVLRNLCLLYSLYGISQKGGDFLEGNIITGAQMSQVNSRILELLTVTRPNAVALVDAFDFKDVTLGSVLGRYDGNVYENLFEWAKKSPLNKTEVHESYYKHLKPLQSKL
uniprot
proteins
ec_number
1.3.3.6
uniprot
proteins
function
FUNCTION: Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids (VLCFAs). Catalyzes the desaturation of fatty acyl-CoAs that have a saturated bond between C2 and C3 (2,3-saturated acyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs), and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)). May play a role in peroxisomal beta-oxidation step in polyunsaturated fatty acids (PUFAs) biosynthesis. Possibly regulates systemic levels of docosahexaenoic acid (DHA, C22:6n-3) through a process involving endoplasmic reticulum desaturation and elongation of alpha-linolenic acid (ALA, C18:3n-3) to form tetracosahexaenoic acid (THA, C24:6n-3), which is then beta-oxidized to DHA in peroxisomes (By similarity). Involved in VLCFA-dependent hepatic-to-adipose tissue inter-organ signaling in response to diet. Through hepatic beta-oxidation of THA, may regulate THA systemic levels and THA-dependent activation of FFAR4 signaling in adipocytes, limiting adipose tissue thermogenesis (PubMed:38760332). {ECO:0000250|UniProtKB:Q15067, ECO:0000269|PubMed:38760332, ECO:0000305|PubMed:11855929, ECO:0000305|PubMed:20195242, ECO:0000305|PubMed:38760332}.; FUNCTION: [Isoform 1]: Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro. {ECO:0000250|UniProtKB:Q15067}.; FUNCTION: [Isoform 2]: Is active against a much broader range of substrates and shows activity towards long-chain and very-long-chain fatty acyl-CoAs. {ECO:0000250|UniProtKB:Q15067}.
uniprot
proteins
mass_dalton
74649
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation. {ECO:0000269|PubMed:11855929, ECO:0000269|PubMed:20195242}.
uniprot
proteins
protein_family
Acyl-CoA oxidase family
uniprot
proteins
pubmed
10672038
uniprot
proteins
pubmed
11855929
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17208939
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20195242
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
38760332
uniprot
proteins
sequence_length
661
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:P07872}.
uniprot
proteins