CTDSPL2
entrez
51496
canonical
uniprot
Q05D32
canonical
ensembl
ENSG00000137770
resolver
ensp
ENSP00000260327
resolver
ensp
ENSP00000452837
resolver
ensp
ENSP00000453051
resolver
ensp
ENSP00000542606
resolver
ensp
ENSP00000607624
resolver
ensp
ENSP00000668008
resolver
ensp
ENSP00000793041
resolver
genesymbol
CTDSPL2
resolver
genesymbol_syn
SCP4
resolver
hgnc
HGNC:26936
resolver
uniprot
Q3ZTU1
resolver
uniprot
Q6AI06
resolver
uniprot
Q8IYI9
resolver
uniprot
Q9NVT2
resolver
uniprot
Q9NZX8
resolver
uniprot
Q9P030
resolver
uniprot_entry
CTSL2_HUMAN
resolver
uniprot_sec
Q3ZTU1
resolver
uniprot_sec
Q6AI06
resolver
uniprot_sec
Q8IYI9
resolver
uniprot_sec
Q9NVT2
resolver
uniprot_sec
Q9NZX8
resolver
uniprot_sec
Q9P030
resolver
amino_acid_sequence
MRLRTRKASQQSNQIQTQRTARAKRKYSEVDDSLPSGGEKPSKNETGLLSSIKKFIKGSTPKEERENPSKRSRIERDIDNNLITSTPRAGEKPNKQISRVRRKSQVNGEAGSYEMTNQHVKQNGKLEDNPSSGSPPRTTLLGTIFSPVFNFFSPANKNGTSGSDSPGQAVEAEEIVKQLDMEQVDEITTSTTTSTNGAAYSNQAVQVRPSLNNGLEEAEETVNRDIPPLTAPVTPDSGYSSAHAEATYEEDWEVFDPYYFIKHVPPLTEEQLNRKPALPLKTRSTPEFSLVLDLDETLVHCSLNELEDAALTFPVLFQDVIYQVYVRLRPFFREFLERMSQMYEIILFTASKKVYADKLLNILDPKKQLVRHRLFREHCVCVQGNYIKDLNILGRDLSKTIIIDNSPQAFAYQLSNGIPIESWFMDKNDNELLKLIPFLEKLVELNEDVRPHIRDRFRLHDLLPPD
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Serine/threonine phosphatase that promotes gluconeogenesis by dephosphorylating FOXO1 and FOXO3A, promoting their nuclear retention and enhancing their transcriptional activity on PCK1 and G6PC1, key enzymes in hepatic gluconeogenesis (PubMed:28851713). Essential for proper embryonic skeletal development by regulating chondrocyte survival through dephosphorylation of FOXO3 (By similarity). By maintaining FOXO3 in its active, dephosphorylated form, inhibits excessive apoptosis of chondrocytes, which is essential for normal endochondral ossification and cartilage formation (By similarity). {ECO:0000250|UniProtKB:Q8BG15, ECO:0000269|PubMed:28851713}.
uniprot
proteins
mass_dalton
52999
uniprot
proteins
mutagenesis
MUTAGEN 295; /note="D->N: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:28851713
uniprot
proteins
protein_family
CTDSPL2 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16533400
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28851713
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28851713}.
uniprot
proteins