TAC3
entrez
6866
canonical
uniprot
Q9UHF0
canonical
ensembl
ENSG00000166863
resolver
ensp
ENSP00000404056
resolver
ensp
ENSP00000408208
resolver
genesymbol
TAC3
resolver
genesymbol_syn
NKNB
resolver
hgnc
HGNC:11521
resolver
uniprot
Q6IAG2
resolver
uniprot
Q71BC6
resolver
uniprot
Q71BC9
resolver
uniprot_entry
TKNK_HUMAN
resolver
uniprot_sec
Q6IAG2
resolver
uniprot_sec
Q71BC6
resolver
uniprot_sec
Q71BC9
resolver
amino_acid_sequence
MRIMLLFTAILAFSLAQSFGAVCKEPQEEVVPGGGRSKRDPDLYQLLQRLFKSHSSLEGLLKALSQASTDPKESTSPEKRDMHDFFVGLMGKRSVQPDSPTDVNQENVPSFGILKYPPRAE
uniprot
proteins
disease_involvement
DISEASE: Hypogonadotropic hypogonadism 10 with or without anosmia (HH10) [MIM:614839]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269|PubMed:19079066, ECO:0000269|PubMed:23643382}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.; FUNCTION: [Neurokinin-B]: Is a ligand for TACR3, and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (PubMed:37391393). Binding to TACR3 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity). Is a critical central regulator of gonadal function (By similarity) (PubMed:19079066). {ECO:0000250|UniProtKB:P08435, ECO:0000269|PubMed:19079066, ECO:0000269|PubMed:37391393}.
uniprot
proteins
mass_dalton
13438
uniprot
proteins
protein_family
Tachykinin family
uniprot
proteins
pubmed
10866201
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19079066
uniprot
proteins
pubmed
23643382
uniprot
proteins
pubmed
37391393
uniprot
proteins
sequence_length
121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins