Ccl20
entrez
20297
canonical
uniprot
O89093
canonical
ensembl
ENSMUSG00000026166
resolver
ensp
ENSMUSP00000109064
resolver
ensp
ENSMUSP00000139923
resolver
genesymbol
Ccl20
resolver
genesymbol_syn
Larc
resolver
genesymbol_syn
Scya20
resolver
uniprot
Q642U4
resolver
uniprot
Q9Z1X3
resolver
uniprot_entry
CCL20_MOUSE
resolver
uniprot_entry
Q642U4_MOUSE
resolver
uniprot_sec
Q9Z1X3
resolver
amino_acid_sequence
MACGGKRLLFLALAWVLLAHLCSQAEAASNYDCCLSYIQTPLPSRAIVGFTRQMADEACDINAIIFHTKKRKSVCADPKQNWVKRAVNLLSLRVKKM
uniprot
proteins
function
FUNCTION: Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:20068036, PubMed:9862452). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (By similarity). Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation (PubMed:19050256). Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (PubMed:24638065). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (PubMed:10064080). {ECO:0000250|UniProtKB:P78556, ECO:0000269|PubMed:10064080, ECO:0000269|PubMed:19050256, ECO:0000269|PubMed:20068036, ECO:0000269|PubMed:24638065, ECO:0000269|PubMed:25122636, ECO:0000269|PubMed:9862452, ECO:0000303|PubMed:21376174}.
uniprot
proteins
mass_dalton
10826
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
10064080
uniprot
proteins
pubmed
11373289
uniprot
proteins
pubmed
19050256
uniprot
proteins
pubmed
20068036
uniprot
proteins
pubmed
21376174
uniprot
proteins
pubmed
24638065
uniprot
proteins
pubmed
25122636
uniprot
proteins
pubmed
9862452
uniprot
proteins
pubmed
9916893
uniprot
proteins
sequence_length
97
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P78556}.
uniprot
proteins