Col4a1
entrez
12826
canonical
uniprot
P02463
canonical
ensembl
ENSMUSG00000031502
resolver
ensp
ENSMUSP00000033898
resolver
enst
ENSMUST00000033898
resolver
genesymbol
Col4a1
resolver
uniprot
Q3UHJ4
resolver
uniprot
Q3UJE7
resolver
uniprot
Q3UQV2
resolver
uniprot
Q53X35
resolver
uniprot
Q6GQS7
resolver
uniprot
Q6PHB5
resolver
uniprot
Q99LQ8
resolver
uniprot_entry
CO4A1_MOUSE
resolver
uniprot_sec
Q3UHJ4
resolver
uniprot_sec
Q3UJE7
resolver
uniprot_sec
Q3UQV2
resolver
uniprot_sec
Q53X35
resolver
uniprot_sec
Q6GQS7
resolver
uniprot_sec
Q6PHB5
resolver
uniprot_sec
Q99LQ8
resolver
amino_acid_sequence
MGPRLSVWLLLLFAALLLHEERSRAAAKGDCGGSGCGKCDCHGVKGQKGERGLPGLQGVIGFPGMQGPEGPHGPPGQKGDAGEPGLPGTKGTRGPPGAAGYPGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFSGNPGPPGLPGMKGDPGEILGHVPGTLLKGERGFPGIPGMPGSPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGSSFQGPKGDKGEQGVSGPPGVPGQAQVKEKGDFAPTGEKGQKGEPGFPGVPGYGEKGEPGKQGPRGKPGKDGEKGERGSPGIPGDSGYPGLPGRQGPQGEKGEAGLPGPPGTVIGTMPLGEKGDRGYPGAPGLRGEPGPKGFPGTPGQPGPPGFPTPGQAGAPGFPGERGEKGDQGFPGVSLPGPSGRDGAPGPPGPPGPPGQPGHTNGIVECQPGPPGDQGPPGTPGQPGLTGEVGQKGQKGESCLACDTEGLRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGLEGLPGPQGSPGLIGQPGAKGEPGEIFFDMRLKGDKGDPGFPGQPGMPGRAGTPGRDGHPGLPGPKGSPGSIGLKGERGPPGGVGFPGSRGDIGPPGPPGVGPIGPVGEKGQAGFPGGPGSPGLPGPKGEAGKVVPLPGPPGAAGLPGSPGFPGPQGDRGFPGTPGRPGIPGEKGAVGQPGIGFPGLPGPKGVDGLPGEIGRPGSPGRPGFNGLPGNPGPQGQKGEPGIGLPGLKGQPGLPGIPGTPGEKGSIGGPGVPGEQGLTGPPGLQGIRGDPGPPGVQGPAGPPGVPGIGPPGAMGPPGGQGPPGSSGPPGIKGEKGFPGFPGLDMPGPKGDKGSQGLPGLTGQSGLPGLPGQQGTPGVPGFPGSKGEMGVMGTPGQPGSPGPAGTPGLPGEKGDHGLPGSSGPRGDPGFKGDKGDVGLPGMPGSMEHVDMGSMKGQKGDQGEKGQIGPTGDKGSRGDPGTPGVPGKDGQAGHPGQPGPKGDPGLSGTPGSPGLPGPKGSVGGMGLPGSPGEKGVPGIPGSQGVPGSPGEKGAKGEKGQSGLPGIGIPGRPGDKGDQGLAGFPGSPGEKGEKGSAGTPGMPGSPGPRGSPGNIGHPGSPGLPGEKGDKGLPGLDGVPGVKGEAGLPGTPGPTGPAGQKGEPGSDGIPGSAGEKGEQGVPGRGFPGFPGSKGDKGSKGEVGFPGLAGSPGIPGVKGEQGFMGPPGPQGQPGLPGTPGHPVEGPKGDRGPQGQPGLPGHPGPMGPPGFPGINGPKGDKGNQGWPGAPGVPGPKGDPGFQGMPGIGGSPGITGSKGDMGLPGVPGFQGQKGLPGLQGVKGDQGDQGVPGPKGLQGPPGPPGPYDVIKGEPGLPGPEGPPGLKGLQGPPGPKGQQGVTGSVGLPGPPGVPGFDGAPGQKGETGPFGPPGPRGFPGPPGPDGLPGSMGPPGTPSVDHGFLVTRHSQTTDDPLCPPGTKILYHGYSLLYVQGNERAHGQDLGTAGSCLRKFSTMPFLFCNINNVCNFASRNDYSYWLSTPEPMPMSMAPISGDNIRPFISRCAVCEAPAMVMAVHSQTIQIPQCPNGWSSLWIGYSFVMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYANAYSFWLATIERSEMFKKPTPSTLKAGELRTHVSRCQVCMRRT
uniprot
proteins
function
FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. {ECO:0000305|PubMed:28424209}.; FUNCTION: Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. {ECO:0000250|UniProtKB:P02462}.
uniprot
proteins
mass_dalton
160679
uniprot
proteins
post_translational_modification
PTM: Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated. The modified lysines can be O-glycosylated. {ECO:0000269|PubMed:25645914}.; PTM: Contains 4-hydroxyproline. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. {ECO:0000269|PubMed:25645914}.; PTM: Contains 3-hydroxyproline. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4-hydroxyproline. {ECO:0000269|PubMed:24368846, ECO:0000269|PubMed:25645914}.; PTM: Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. {ECO:0000250|UniProtKB:P02462}.; PTM: The trimeric structure of the NC1 domains is stabilized by covalent bonds (sulfilimine cross-links) between Lys and Met residues. These cross-links are important for the mechanical stability of the basement membrane (PubMed:22842973, PubMed:28424209). Sulfilimine cross-link is catalyzed by PXDN (PubMed:22842973). {ECO:0000269|PubMed:22842973, ECO:0000269|PubMed:28424209}.; PTM: Proteolytic processing produces the C-terminal NC1 peptide, arresten. {ECO:0000250|UniProtKB:P02462}.
uniprot
proteins
protein_family
Type IV collagen family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15905400
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17324935
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22842973
uniprot
proteins
pubmed
24368846
uniprot
proteins
pubmed
25645914
uniprot
proteins
pubmed
2578961
uniprot
proteins
pubmed
2703490
uniprot
proteins
pubmed
2842328
uniprot
proteins
pubmed
28424209
uniprot
proteins
pubmed
3009468
uniprot
proteins
pubmed
3198626
uniprot
proteins
pubmed
3200851
uniprot
proteins
pubmed
3338568
uniprot
proteins
pubmed
3379041
uniprot
proteins
pubmed
3597383
uniprot
proteins
pubmed
3755692
uniprot
proteins
sequence_length
1669
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:24368846}.
uniprot
proteins