ADM
entrez
133
canonical
uniprot
P35318
canonical
ensembl
ENSG00000148926
resolver
ensp
ENSP00000278175
resolver
ensp
ENSP00000435124
resolver
ensp
ENSP00000436607
resolver
ensp
ENSP00000549187
resolver
ensp
ENSP00000582146
resolver
ensp
ENSP00000633894
resolver
enst
ENST00000278175
resolver
enst
ENST00000525063
resolver
enst
ENST00000528655
resolver
enst
ENST00000879128
resolver
enst
ENST00000912087
resolver
enst
ENST00000963835
resolver
genesymbol
ADM
resolver
genesymbol_syn
AM
resolver
hgnc
HGNC:259
resolver
uniprot
B2R793
resolver
uniprot
D3DQV3
resolver
uniprot
Q6FGW2
resolver
uniprot_entry
ADML_HUMAN
resolver
uniprot_sec
B2R793
resolver
uniprot_sec
D3DQV3
resolver
uniprot_sec
Q6FGW2
resolver
amino_acid_sequence
MKLVSVALMYLGSLAFLGADTARLDVASEFRKKWNKWALSRGKRELRMSSSYPTGLADVKAGPAQTLIRPQDMKGASRSPEDSSPDAARIRVKRYRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSKISPQGYGRRRRRSLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL
uniprot
proteins
function
FUNCTION: Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents (PubMed:8387282, PubMed:9620797). Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. {ECO:0000269|PubMed:8387282, ECO:0000269|PubMed:9620797}.; FUNCTION: [Adrenomedullin]: Peptide hormone that act as potent hypotensive and vasodilatator agents (PubMed:8387282). ADM function is mediated by the CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes with ADM showing the highest potency for the CALCRL-RAMP2 complex (PubMed:32296767, PubMed:9620797). {ECO:0000269|PubMed:32296767, ECO:0000269|PubMed:8387282, ECO:0000269|PubMed:9620797}.; FUNCTION: [Proadrenomedullin N-20 terminal peptide]: Peptide hormone that act as potent hypotensive and vasodilatator agents by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells (PubMed:10588445, PubMed:9578982). Acts as a ligand for MRGPRX2 receptor in mast cells (PubMed:15823563). {ECO:0000269|PubMed:15823563, ECO:0000303|PubMed:10588445, ECO:0000303|PubMed:9578982}.; FUNCTION: [Proadrenomedullin 9-20 terminal peptide]: Peptide hormone that act as potent hypotensive and vasodilatator agents by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells (PubMed:10588445, PubMed:9578982). Acts as a ligand for MRGPRX2 receptor in mast cells (PubMed:15823563, PubMed:34789875). {ECO:0000269|PubMed:15823563, ECO:0000269|PubMed:34789875, ECO:0000303|PubMed:10588445, ECO:0000303|PubMed:9578982}.
uniprot
proteins
mass_dalton
20420
uniprot
proteins
protein_family
Adrenomedullin family
uniprot
proteins
pubmed
10588445
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15823563
uniprot
proteins
pubmed
16315141
uniprot
proteins
pubmed
32296767
uniprot
proteins
pubmed
34789875
uniprot
proteins
pubmed
7688224
uniprot
proteins
pubmed
8074714
uniprot
proteins
pubmed
8387282
uniprot
proteins
pubmed
9578982
uniprot
proteins
pubmed
9620797
uniprot
proteins
sequence_length
185
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8387282}.
uniprot
proteins