Ngf
entrez
18049
canonical
uniprot
P01139
canonical
ensembl
ENSMUSG00000027859
resolver
ensp
ENSMUSP00000040345
resolver
ensp
ENSMUSP00000102538
resolver
enst
ENSMUST00000035952
resolver
enst
ENSMUST00000106925
resolver
genesymbol
Ngf
resolver
genesymbol_syn
Ngfb
resolver
uniprot
Q3UMZ8
resolver
uniprot
Q63864
resolver
uniprot
Q6LDB7
resolver
uniprot
Q6LDU8
resolver
uniprot_entry
NGF_MOUSE
resolver
uniprot_entry
Q3UMZ8_MOUSE
resolver
uniprot_entry
Q6LDU8_MOUSE
resolver
uniprot_sec
Q63864
resolver
uniprot_sec
Q6LDB7
resolver
amino_acid_sequence
MSMLFYTLITAFLIGVQAEPYTDSNVPEGDSVPEAHWTKLQHSLDTALRRARSAPTAPIAARVTGQTRNITVDPRLFKKRRLHSPRVLFSTQPPPTSSDTLDLDFQAHGTIPFNRTHRSKRSSTHPVFHMGEFSVCDSVSVWVGDKTTATDIKGKEVTVLAEVNINNSVFRQYFFETKCRASNPVESGCRGIDSKHWNSYCTTTHTFVKALTTDEKQAAWRFIRIDTACVCVLSRKATRRG
uniprot
proteins
function
FUNCTION: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:20036257). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:22649032). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse (PubMed:22155786). In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (PubMed:20036257). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer (PubMed:22649032, PubMed:26144237). The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (PubMed:22649032). {ECO:0000250|UniProtKB:P01138, ECO:0000269|PubMed:20036257, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:22649032, ECO:0000269|PubMed:26144237}.
uniprot
proteins
mass_dalton
27077
uniprot
proteins
mutagenesis
MUTAGEN 49..50; /note="RR->AA: Abolishes production of the mature chain and promotes apoptosis of superior cervical ganglion neurons; when associated with 79-A-A-80 and 120-A-A-121."; /evidence="ECO:0000269|PubMed:20036257"; MUTAGEN 79..80; /note="KR->AA: Abolishes production of the mature chain and promotes apoptosis of superior cervical ganglion neurons; when associated with 49-A-A-50 and 120-A-A-121."; /evidence="ECO:0000269|PubMed:20036257"; MUTAGEN 120..121; /note="KR->AA: Abolishes production of the mature chain and promotes apoptosis of superior cervical ganglion neurons; when associated with 49-A-A-50 and 79-A-A-80."; /evidence="ECO:0000269|PubMed:20036257"; MUTAGEN 209; /note="K->L: Near loss of the ability to trigger histamine release from mast cells. No effect on interaction with NTRK1."; /evidence="ECO:0000269|PubMed:22649032
uniprot
proteins
protein_family
NGF-beta family
uniprot
proteins
pubmed
1284621
uniprot
proteins
pubmed
1956407
uniprot
proteins
pubmed
20036257
uniprot
proteins
pubmed
22155786
uniprot
proteins
pubmed
22649032
uniprot
proteins
pubmed
23785138
uniprot
proteins
pubmed
24908487
uniprot
proteins
pubmed
26144237
uniprot
proteins
pubmed
30061605
uniprot
proteins
pubmed
3670305
uniprot
proteins
pubmed
4566923
uniprot
proteins
pubmed
6327169
uniprot
proteins
pubmed
6336309
uniprot
proteins
pubmed
6688123
uniprot
proteins
pubmed
8201620
uniprot
proteins
pubmed
9351801
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1284621}. Endosome lumen {ECO:0000269|PubMed:20036257}. Note=ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR. {ECO:0000269|PubMed:20036257}.
uniprot
proteins