Bin2
entrez
366988
canonical
uniprot
Q68FR2
canonical
ensembl
ENSRNOG00000031930
resolver
ensp
ENSRNOP00000039630
resolver
genesymbol
Bin2
resolver
uniprot_entry
BIN2_RAT
resolver
amino_acid_sequence
MAEGKAGGAAGLFAKQMQKKFSRAQEKVLQKLGKTVETKDERFEQSASNFYQQQAEGHRLYKDLKNFLSAVKVMRESSKRVSETLQEIYNSDWDGHEDLKAIVGNNDLLWEDYEEKLADQALRTMENYVSQFSEVKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKMAKAEEDFSKAQVVFEDLNQELLEELPVLYNSRIGCYVTVFQNISNLRDVFYREMSKLNHSLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVQTCTAFSPVSPVTSPTSPNALSVTSESESVSATAEELTSEAVGEDSCESEESLKDEEADEDQSETSSSEEEEDEDEDEDEEESLAACNGPTPTPAPTPAPASPAAEVKSQEEAAPCSPTSSLGRGQTGKEHSPPGEVVLRARASSEGAEQSKRTASVQRTSAPPSRPPPPKASGGGLSSPPGSAEASKACHPRASSDASSDPEPPETGEKEGTGSSGPKEPHASSTKSATQVVSNDENTEL
uniprot
proteins
function
FUNCTION: Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation (By similarity). Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000250, ECO:0000269|PubMed:23285027}.
uniprot
proteins
mass_dalton
55118
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23285027
uniprot
proteins
sequence_length
507
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UBW5}. Cell projection, podosome membrane {ECO:0000269|PubMed:23285027}; Peripheral membrane protein {ECO:0000269|PubMed:23285027}; Cytoplasmic side {ECO:0000269|PubMed:23285027}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9UBW5}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q9UBW5}. Note=Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure. {ECO:0000250|UniProtKB:Q9UBW5}.
uniprot
proteins