Pigu
entrez
353304
canonical
uniprot
Q8CHJ1
canonical
ensembl
ENSRNOG00000025181
resolver
ensembl
ENSRNOG00055024253
resolver
ensembl
ENSRNOG00060027148
resolver
ensembl
ENSRNOG00065028148
resolver
ensp
ENSRNOP00000032963
resolver
ensp
ENSRNOP00000075495
resolver
enst
ENSRNOT00000089935
resolver
genesymbol
Pigu
resolver
genesymbol_syn
Cdc91l1
resolver
uniprot
A0A0G2KAR3
resolver
uniprot_entry
A0A0G2KAR3_RAT
resolver
uniprot_entry
PIGU_RAT
resolver
amino_acid_sequence
MAAPLALVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLALLDLGVSPYSGAVFHETPLIIYLFHFLIDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSVFLSAIFLALATYQSLYPITLFAPGLLYLLQRQYIPVKVKSKAFWIFSWEYAMMYTGSLVVIVCLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTVPLAIKLKEHPIFFMFIQIAIISIFKSYPTVGDVALYMAFFPVWSHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAGSANSNFFYAITLTFNVGQILLISDYFYAFLRREYYLTHGLYLTAKDGTEAMLVLK
uniprot
proteins
function
FUNCTION: Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis (PubMed:12802054). Binds the lipid portion of GPI-anchor. May act as an organizer in the transmembrane layer to recruit other subunits, and thus is essential for assembly of the complex (By similarity). {ECO:0000250|UniProtKB:Q9H490, ECO:0000269|PubMed:12802054}.
uniprot
proteins
mass_dalton
49953
uniprot
proteins
pathway_participation
PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000269|PubMed:12802054}.
uniprot
proteins
protein_family
PIGU family
uniprot
proteins
pubmed
12802054
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9H490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H490}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..22; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 137..158; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 159..178; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 179..194; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 195..205; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 223..244; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 287..306; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 312..331; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 332..345; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 355..372; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490"; TRANSMEM 385..406; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9H490
uniprot
proteins