Dlg2
entrez
64053
canonical
uniprot
Q63622
canonical
ensembl
ENSRNOG00000022635
resolver
ensp
ENSRNOP00000076548
resolver
ensp
ENSRNOP00000078924
resolver
ensp
ENSRNOP00000079565
resolver
ensp
ENSRNOP00000107730
resolver
enst
ENSRNOT00000095796
resolver
enst
ENSRNOT00000106839
resolver
enst
ENSRNOT00000112321
resolver
enst
ENSRNOT00000139981
resolver
genesymbol
Dlg2
resolver
genesymbol_syn
Dlgh2
resolver
uniprot
A0A8I5ZK38
resolver
uniprot
A0A8I5ZMA3
resolver
uniprot
A0A8I6G5H5
resolver
uniprot
A0ABK0LB07
resolver
uniprot
P70548
resolver
uniprot
Q62939
resolver
uniprot_entry
A0A8I5ZK38_RAT
resolver
uniprot_entry
A0A8I5ZMA3_RAT
resolver
uniprot_entry
A0A8I6G5H5_RAT
resolver
uniprot_entry
A0ABK0LB07_RAT
resolver
uniprot_entry
DLG2_RAT
resolver
uniprot_sec
P70548
resolver
uniprot_sec
Q62939
resolver
amino_acid_sequence
MFFACYCALRTNVKKYRYQDEDGPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSTPYPHYHLGLLPDSDMTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVILDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
uniprot
proteins
function
FUNCTION: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
94934
uniprot
proteins
mutagenesis
MUTAGEN 5; /note="C->S: Loss of palmitoylation and targeting to postsynaptic density."; /evidence="ECO:0000269|PubMed:10779526"; MUTAGEN 7; /note="C->S: Loss of palmitoylation and targeting to postsynaptic density."; /evidence="ECO:0000269|PubMed:10779526
uniprot
proteins
post_translational_modification
PTM: Palmitoylation of isoform 1 and isoform 2 is not required for targeting to postsynaptic density. {ECO:0000269|PubMed:10779526}.
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
10779526
uniprot
proteins
pubmed
11095503
uniprot
proteins
pubmed
11997254
uniprot
proteins
pubmed
15304517
uniprot
proteins
pubmed
16630835
uniprot
proteins
pubmed
19118189
uniprot
proteins
pubmed
20089912
uniprot
proteins
pubmed
21119615
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8625413
uniprot
proteins
pubmed
8755482
uniprot
proteins
pubmed
8922396
uniprot
proteins
sequence_length
852
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10779526}; Lipid-anchor {ECO:0000269|PubMed:10779526}. Postsynaptic density {ECO:0000269|PubMed:11095503}. Synapse. Cell projection, axon {ECO:0000269|PubMed:20089912}. Membrane {ECO:0000269|PubMed:11997254, ECO:0000269|PubMed:20089912}. Perikaryon {ECO:0000269|PubMed:11095503}. Note=Concentrated in soma and postsynaptic density of a subset of neurons (PubMed:11095503). {ECO:0000269|PubMed:11095503}.
uniprot
proteins