LYPD6B
entrez
130576
canonical
uniprot
Q8NI32
canonical
ensembl
ENSG00000150556
resolver
ensp
ENSP00000280115
resolver
ensp
ENSP00000386479
resolver
ensp
ENSP00000386650
resolver
ensp
ENSP00000387077
resolver
ensp
ENSP00000569503
resolver
ensp
ENSP00000569506
resolver
ensp
ENSP00000569507
resolver
ensp
ENSP00000569508
resolver
ensp
ENSP00000569510
resolver
ensp
ENSP00000569511
resolver
ensp
ENSP00000569512
resolver
ensp
ENSP00000621220
resolver
ensp
ENSP00000774512
resolver
ensp
ENSP00000774514
resolver
genesymbol
LYPD6B
resolver
hgnc
HGNC:27018
resolver
uniprot
D3DP90
resolver
uniprot
Q53TK0
resolver
uniprot
Q7Z747
resolver
uniprot
Q8IXK7
resolver
uniprot_entry
LPD6B_HUMAN
resolver
uniprot_sec
D3DP90
resolver
uniprot_sec
Q53TK0
resolver
uniprot_sec
Q7Z747
resolver
uniprot_sec
Q8IXK7
resolver
amino_acid_sequence
MLYKSSDRPAHKVSMLLLCHALAIAVVQIVIFSESWAFAKNINFYNVRPPLDPTPFPNSFKCFTCENAGDNYNCNRWAEDKWCPQNTQYCLTVHHFTSHGRSTSITKKCASRSECHFVGCHHSRDSEHTECRSCCEGMICNVELPTNHTNAVFAVMHAQRTSGSSAPTLYLPVLAWVFVLPLL
uniprot
proteins
function
FUNCTION: Likely acts as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (PubMed:26586467, PubMed:34631692). In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner (PubMed:26586467). Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence (PubMed:26586467). However, according to another report in vitro it can weakly inhibits alpha-7 nAChRs (PubMed:34631692). {ECO:0000269|PubMed:26586467, ECO:0000269|PubMed:34631692}.
uniprot
proteins
mass_dalton
20656
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
26586467
uniprot
proteins
pubmed
33019770
uniprot
proteins
pubmed
34631692
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
uniprot
proteins