TM4SF19
entrez
116211
canonical
uniprot
Q96DZ7
canonical
ensembl
ENSG00000145107
resolver
ensembl
ENSG00000273331
resolver
ensp
ENSP00000273695
resolver
ensp
ENSP00000387728
resolver
genesymbol
TM4SF19
resolver
genesymbol_syn
OCTM4
resolver
hgnc
HGNC:25167
resolver
uniprot
B2RV20
resolver
uniprot
B7ZW46
resolver
uniprot
E9PH22
resolver
uniprot
Q336K7
resolver
uniprot_entry
B7ZW46_HUMAN
resolver
uniprot_entry
T4S19_HUMAN
resolver
uniprot_sec
B2RV20
resolver
uniprot_sec
E9PH22
resolver
uniprot_sec
Q336K7
resolver
amino_acid_sequence
MVSSPCTQASSRTCSRILGLSLGTAALFAAGANVALLLPNWDVTYLLRGLLGRHAMLGTGLWGGGLMVLTAAILISLMGWRYGCFSKSGLCRSVLTALLSGGLALLGALICFVTSGVALKDGPFCMFDVSSFNQTQAWKYGYPFKDLHSRNYLYDRSLWNSVCLEPSAAVVWHVSLFSALLCISLLQLLLVVVHVINSLLGLFCSLCEK
uniprot
proteins
function
FUNCTION: Negatively regulates vacuolar (H+)-ATPase (V-ATPase) activity by interacting with members of V-ATPase V0 complex and hence inhibiting V1-V0 complex assembly. Required for multinucleation during osteoclast differentiation. {ECO:0000250|UniProtKB:E9Q9H8}.
uniprot
proteins
mass_dalton
22433
uniprot
proteins
protein_family
L6 tetraspanin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
33059922
uniprot
proteins
pubmed
38016540
uniprot
proteins
pubmed
38555350
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:E9Q9H8}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:E9Q9H8}. Cell projection, filopodium {ECO:0000250|UniProtKB:E9Q9H8}. Note=In osteoclasts, localizes not only to the actin ring, but also to the filopodia, the stretched structures for searching cells to fuse, and the fusopod, the cytoplasmic bridge for contacting other osteoclasts to fuse. {ECO:0000250|UniProtKB:E9Q9H8}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 60..80; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 176..196; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins