Hspa2
entrez
15512
canonical
uniprot
P17156
canonical
ensembl
ENSMUSG00000059970
resolver
ensp
ENSMUSP00000079306
resolver
ensp
ENSMUSP00000151408
resolver
ensp
ENSMUSP00000190079
resolver
enst
ENSMUST00000080449
resolver
enst
ENSMUST00000219555
resolver
genesymbol
Hspa2
resolver
genesymbol_syn
Hcp70.2
resolver
genesymbol_syn
Hsp70-2
resolver
uniprot
Q99KD7
resolver
uniprot_entry
HSP72_MOUSE
resolver
uniprot_sec
Q99KD7
resolver
amino_acid_sequence
MSARGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGEMKTFFPEEISSMVLTKMKEIAEAYLGGKVQSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDLLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQEAERYKSEDEANRDRVAAKNAVESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQMAEKDEYEHKQKELERVCNPIISKLYQGGPGGGGSSGGPTIEEVD
uniprot
proteins
function
FUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (By similarity). Plays a role in spermatogenesis (PubMed:24557841). In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (PubMed:24557841). {ECO:0000250|UniProtKB:P54652, ECO:0000269|PubMed:24557841}.
uniprot
proteins
mass_dalton
69642
uniprot
proteins
protein_family
Heat shock protein 70 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18849567
uniprot
proteins
pubmed
20547853
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21224844
uniprot
proteins
pubmed
23055941
uniprot
proteins
pubmed
24557841
uniprot
proteins
pubmed
3405224
uniprot
proteins
pubmed
39868537
uniprot
proteins
sequence_length
633
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:24557841}. Note=Colocalizes with SHCBP1L at spindle during the meiosis process (PubMed:24557841). {ECO:0000269|PubMed:24557841}.
uniprot
proteins