Spry2
entrez
24064
canonical
uniprot
Q9QXV8
canonical
ensembl
ENSMUSG00000022114
resolver
ensp
ENSMUSP00000022709
resolver
ensp
ENSMUSP00000246218
resolver
enst
ENSMUST00000022709
resolver
genesymbol
Spry2
resolver
uniprot
B2RS85
resolver
uniprot
Q9WUQ9
resolver
uniprot_entry
B2RS85_MOUSE
resolver
uniprot_entry
SPY2_MOUSE
resolver
uniprot_sec
Q9WUQ9
resolver
amino_acid_sequence
MEARAQSGNGSQPLLQTAHDSGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQPSQVHSSRAPLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGPSFSHGPAAADGIIRVQPKSELKPGDVKPLSKDDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT
uniprot
proteins
function
FUNCTION: Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (PubMed:29501879). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (PubMed:10074434, PubMed:10498682, PubMed:29501879). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (PubMed:25576668). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (By similarity). {ECO:0000250|UniProtKB:O43597, ECO:0000269|PubMed:10074434, ECO:0000269|PubMed:10498682, ECO:0000269|PubMed:25576668, ECO:0000269|PubMed:29501879}.
uniprot
proteins
mass_dalton
34623
uniprot
proteins
mutagenesis
MUTAGEN 55; /note="Y->A: Abolishes FGF2-induced lens fiber differentiation via inhibition of FGF-mediated ERK1/2 phosphorylation."; /evidence="ECO:0000269|PubMed:29501879
uniprot
proteins
post_translational_modification
PTM: Cleaved at Pro-143 by the prolyl endopeptidase FAP (seprase) activity (in vitro). {ECO:0000250|UniProtKB:O43597}.
uniprot
proteins
protein_family
Sprouty family
uniprot
proteins
pubmed
10074434
uniprot
proteins
pubmed
10498682
uniprot
proteins
pubmed
16877379
uniprot
proteins
pubmed
17974561
uniprot
proteins
pubmed
25576668
uniprot
proteins
pubmed
29501879
uniprot
proteins
sequence_length
315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O43597}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O43597}. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor). {ECO:0000250|UniProtKB:O43597}.
uniprot
proteins