CADM2
entrez
253559
canonical
uniprot
Q8N3J6
canonical
ensembl
ENSG00000175161
resolver
ensp
ENSP00000373200
resolver
ensp
ENSP00000384193
resolver
ensp
ENSP00000384575
resolver
genesymbol
CADM2
resolver
genesymbol_syn
IGSF4D
resolver
genesymbol_syn
NECL3
resolver
hgnc
HGNC:29849
resolver
uniprot
G3XHN4
resolver
uniprot
G3XHN7
resolver
uniprot
G3XHN8
resolver
uniprot
Q3KQY9
resolver
uniprot
Q658Q7
resolver
uniprot
Q8IZP8
resolver
uniprot_entry
CADM2_HUMAN
resolver
uniprot_entry
G3XHN4_HUMAN
resolver
uniprot_sec
G3XHN7
resolver
uniprot_sec
G3XHN8
resolver
uniprot_sec
Q3KQY9
resolver
uniprot_sec
Q658Q7
resolver
uniprot_sec
Q8IZP8
resolver
amino_acid_sequence
MIWKRSAVLRFYSVCGLLLQGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESKGKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDVPNTLLPTTIIPSLTTATVTTTVAITTSPTTSATTSSIRDPNALAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQVNAEEKKEYFI
uniprot
proteins
function
FUNCTION: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. {ECO:0000269|PubMed:17967169}.; FUNCTION: [Isoform 5]: (Microbial infection) Induces cell fusion in neuron infected by a neuropathogenic strain of measles. Interacts with measles hemagglutinin to trigger hyperfusogenic F-mediated membrane fusion and presumably transsynaptic cell-to-cell transmission of the virus. {ECO:0000269|PubMed:37166307}.
uniprot
proteins
mass_dalton
47554
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17967169
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21864505
uniprot
proteins
pubmed
37166307
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17967169}; Single-pass type I membrane protein {ECO:0000269|PubMed:17967169}. Synapse {ECO:0000269|PubMed:17967169}. Cell projection, axon {ECO:0000269|PubMed:17967169}. Note=Found in the axoplasm of myelinated axons.
uniprot
proteins
transmembrane_region
TRANSMEM 368..388; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins