ENAH
entrez
55740
canonical
uniprot
Q8N8S7
canonical
ensembl
ENSG00000154380
resolver
ensp
ENSP00000355808
resolver
ensp
ENSP00000355809
resolver
ensp
ENSP00000563282
resolver
ensp
ENSP00000563283
resolver
ensp
ENSP00000563284
resolver
ensp
ENSP00000563289
resolver
genesymbol
ENAH
resolver
genesymbol_syn
MENA
resolver
hgnc
HGNC:18271
resolver
uniprot
A0A097PIC4
resolver
uniprot
A0A097PID1
resolver
uniprot
A0A4D6J698
resolver
uniprot
D0PQI2
resolver
uniprot
Q502W5
resolver
uniprot
Q5T5M7
resolver
uniprot
Q5VTQ9
resolver
uniprot
Q5VTR0
resolver
uniprot
Q9NVF3
resolver
uniprot
Q9UFB8
resolver
uniprot_entry
A0A097PIC4_HUMAN
resolver
uniprot_entry
A0A097PID1_HUMAN
resolver
uniprot_entry
A0A4D6J698_HUMAN
resolver
uniprot_entry
ENAH_HUMAN
resolver
uniprot_sec
D0PQI2
resolver
uniprot_sec
Q502W5
resolver
uniprot_sec
Q5T5M7
resolver
uniprot_sec
Q5VTQ9
resolver
uniprot_sec
Q5VTR0
resolver
uniprot_sec
Q9NVF3
resolver
uniprot_sec
Q9UFB8
resolver
amino_acid_sequence
MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDKGEDSEPVTSKASSTSTPEPTRKPWERTNTMNGSKSPVISRRDSPRKNQIVFDNRSYDSLHRPKSTPLSQPSANGVQTEGLDYDRLKQDILDEMRKELTKLKEELIDAIRQELSKSNTA
uniprot
proteins
function
FUNCTION: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}.
uniprot
proteins
mass_dalton
66510
uniprot
proteins
post_translational_modification
PTM: NTN1-induced PKA phosphorylation on Ser-265 directly parallels the formation of filopodial protrusions. {ECO:0000250}.
uniprot
proteins
protein_family
Ena/VASP family
uniprot
proteins
pubmed
10801818
uniprot
proteins
pubmed
11696321
uniprot
proteins
pubmed
12941633
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15027125
uniprot
proteins
pubmed
15469845
uniprot
proteins
pubmed
15469846
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17686488
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18158903
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21278383
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23129656
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9312002
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Synapse {ECO:0000250}. Cell junction, focal adhesion. Note=Targeted to the leading edge of lamellipodia and filopodia by MRL family members. Colocalizes at filopodial tips with a number of other proteins including vinculin and zyxlin. Colocalizes with N-WASP at the leading edge. Colocalizes with GPHN and PFN at synapses (By similarity). {ECO:0000250}.
uniprot
proteins