Nphp1
entrez
53885
canonical
uniprot
Q9QY53
canonical
ensembl
ENSMUSG00000027378
resolver
ensp
ENSMUSP00000028857
resolver
ensp
ENSMUSP00000105986
resolver
ensp
ENSMUSP00000176123
resolver
ensp
ENSMUSP00000176124
resolver
ensp
ENSMUSP00000176125
resolver
ensp
ENSMUSP00000176126
resolver
ensp
ENSMUSP00000176136
resolver
ensp
ENSMUSP00000176137
resolver
ensp
ENSMUSP00000176142
resolver
ensp
ENSMUSP00000176144
resolver
ensp
ENSMUSP00000176147
resolver
ensp
ENSMUSP00000176151
resolver
ensp
ENSMUSP00000336878
resolver
enst
ENSMUST00000028857
resolver
enst
ENSMUST00000110357
resolver
genesymbol
Nphp1
resolver
genesymbol_syn
Nph1
resolver
uniprot
A2APS1
resolver
uniprot
F7AMG9
resolver
uniprot
Q3TWM5
resolver
uniprot
Q9D7G8
resolver
uniprot
Q9QZP0
resolver
uniprot
Q9WUZ2
resolver
uniprot_entry
A2APS1_MOUSE
resolver
uniprot_entry
F7AMG9_MOUSE
resolver
uniprot_entry
NPHP1_MOUSE
resolver
uniprot_entry
Q3TWM5_MOUSE
resolver
uniprot_sec
Q9D7G8
resolver
uniprot_sec
Q9QZP0
resolver
uniprot_sec
Q9WUZ2
resolver
amino_acid_sequence
MLARRPRDPLQALRRRGQELKLQVDSLVTESQLTGALEPSKRREIYQRCIQLKQAVDENKNTLQKLNKADEAAPVGNYEQRKEEEHSLLEKLACQLQELAVSISRKDALKVEAHSDKEEDDTTEDDEEETGGEEEESEGDGEGKQEQASPKQAETETVTYIALGDFAAQQTGDLTFKKGDVLHIIEKKPDGWWLAKDAEGVEGLIPRTYLEPYNKEDKLESSEGSEEGGEEDGEEDVEVVDETADGAQVKQRTDSHWSAVRKAISEQINTVDVLATMGAIPAGFRPSTLSQLLDEAGNQFRASYFLQPELTTSQLAFRDLTWDAKAGTIMSRPSRVSLILTLWSCKMIPLPGTSIQVLSRHIRLCLFDGSKVLSNIHTVRAVWQPKKPKTWTFSPQVTGILPCLLDGDCFIRSNSSTPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGVEVDPSVSRRAQGSVFRQMISVRRQPQLLVKLRSLNRRSRAMLSLLPETLVGSMCSAHLLIFYRQILGDVLLRDRTNLQSADLISHPVLATFPLLLEQPDVMDALRSSWSEKESTLKRAEKRDKELLKAEFLLVYHDCVLPLLHSTLLPPFRWAEEETEAARWKAIADFLKQSRENEGSLKALLSPDGVHKPFDLSEQTFDFLGEIRKNSG
uniprot
proteins
function
FUNCTION: Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells, together with NPHP4 and RPGRIP1L/NPHP8 (PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:19208653). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (PubMed:11493697). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly (PubMed:19208653). Required for normal retina development (PubMed:19208653). In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19 (PubMed:19208653). Involved in spermatogenesis; required for the differentiation of early elongating spermatids into spermatozoa (PubMed:18684731). {ECO:0000269|PubMed:11493697, ECO:0000269|PubMed:18684731, ECO:0000269|PubMed:19208653, ECO:0000269|PubMed:21565611}.
uniprot
proteins
mass_dalton
77035
uniprot
proteins
protein_family
Nephrocystin-1 family
uniprot
proteins
pubmed
10665934
uniprot
proteins
pubmed
10739664
uniprot
proteins
pubmed
11493697
uniprot
proteins
pubmed
12006559
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16885411
uniprot
proteins
pubmed
18477472
uniprot
proteins
pubmed
18684731
uniprot
proteins
pubmed
19208653
uniprot
proteins
pubmed
20856870
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21565611
uniprot
proteins
pubmed
25671767
uniprot
proteins
pubmed
29899041
uniprot
proteins
sequence_length
687
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction {ECO:0000269|PubMed:12006559, ECO:0000269|PubMed:18477472}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9TU19}. Cell projection, cilium {ECO:0000269|PubMed:16885411, ECO:0000269|PubMed:19208653, ECO:0000269|PubMed:29899041}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:19208653}. Cell junction, tight junction {ECO:0000269|PubMed:10739664}. Note=In the retinal photoreceptor cell layer, localizes at the connecting cilium (PubMed:19208653, PubMed:29899041). Colocalizes with E-cadherin and BCAR1 at or near the cell-cell adherens junctions (PubMed:10739664). Localizes to respiratory cilia axoneme (PubMed:16885411). Localized to the transition zone of respiratory cilia (PubMed:16885411). Localized to the transition zone of photoreceptor-connecting cilia and renal monocilia (PubMed:16885411). In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates at basolateral tight junctions (PubMed:21565611). {ECO:0000269|PubMed:10739664, ECO:0000269|PubMed:16885411, ECO:0000269|PubMed:19208653, ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:29899041}.
uniprot
proteins