Cyp24a1
entrez
25279
canonical
uniprot
Q09128
canonical
ensembl
ENSRNOG00000013062
resolver
ensp
ENSRNOP00000043298
resolver
enst
ENSRNOT00000046011
resolver
genesymbol
Cyp24a1
resolver
genesymbol_syn
Cyp24
resolver
uniprot
Q498V4
resolver
uniprot
Q63685
resolver
uniprot_entry
CP24A_RAT
resolver
uniprot_sec
Q498V4
resolver
uniprot_sec
Q63685
resolver
amino_acid_sequence
MSCPIDKRRTLIAFLRRLRDLGQPPRSVTSKASASRAPKEVPLCPLMTDGETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRPR
uniprot
proteins
ec_number
1.14.15.16
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24-oxidation pathway, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:10231362, PubMed:16617161, PubMed:2026586). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid (PubMed:10231362, PubMed:16617161). Hydroxylates at C-24 or C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol (PubMed:25727742). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:2026586). {ECO:0000269|PubMed:10231362, ECO:0000269|PubMed:16617161, ECO:0000269|PubMed:2026586, ECO:0000269|PubMed:25727742}.
uniprot
proteins
mass_dalton
59448
uniprot
proteins
mutagenesis
MUTAGEN 416; /note="T->F: Increases the C23:C24 hydroxylation ratio from 0.01 to 0.12."; /evidence="ECO:0000269|PubMed:16617161"; MUTAGEN 416; /note="T->I: Increases the C23:C24 hydroxylation ratio from 0.01 to 0.19."; /evidence="ECO:0000269|PubMed:16617161"; MUTAGEN 416; /note="T->M: Increases the C23:C24 hydroxylation ratio from 0.01 to 0.08."; /evidence="ECO:0000269|PubMed:16617161"; MUTAGEN 416; /note="T->V: Increases the C23:C24 hydroxylation ratio from 0.01 to 0.16."; /evidence="ECO:0000269|PubMed:16617161"; MUTAGEN 500; /note="I->A: Increases the C23:C24 hydroxylation ratio from 0.01 to 0.15."; /evidence="ECO:0000269|PubMed:16617161"; MUTAGEN 500; /note="I->T,L: Increases the C23:C24 hydroxylation ratio from 0.01 to 0.16."; /evidence="ECO:0000269|PubMed:16617161"; MUTAGEN 500; /note="I->V: Increases the C23:C24 hydroxylation ratio from 0.01 to 0.13."; /evidence="ECO:0000269|PubMed:16617161
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10231362
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15574355
uniprot
proteins
pubmed
16617161
uniprot
proteins
pubmed
1991512
uniprot
proteins
pubmed
19961857
uniprot
proteins
pubmed
2026586
uniprot
proteins
pubmed
25727742
uniprot
proteins
pubmed
8036172
uniprot
proteins
pubmed
8418863
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305|PubMed:2026586}.
uniprot
proteins