Ikbkg
entrez
309295
canonical
uniprot
Q6TMG5
canonical
ensembl
ENSRNOG00000060936
resolver
ensembl
ENSRNOG00055023876
resolver
ensembl
ENSRNOG00060007005
resolver
ensembl
ENSRNOG00065015300
resolver
ensp
ENSRNOP00000075158
resolver
ensp
ENSRNOP00000092097
resolver
ensp
ENSRNOP00000100028
resolver
ensp
ENSRNOP00000110774
resolver
ensp
ENSRNOP00055033314
resolver
ensp
ENSRNOP00060008633
resolver
ensp
ENSRNOP00065019917
resolver
enst
ENSRNOT00000107762
resolver
enst
ENSRNOT00000122628
resolver
enst
ENSRNOT00000129825
resolver
enst
ENSRNOT00055040983
resolver
enst
ENSRNOT00060011512
resolver
enst
ENSRNOT00065025392
resolver
genesymbol
Ikbkg
resolver
genesymbol_syn
Nemo
resolver
uniprot
A0A8I6AH74
resolver
uniprot
A0ABK0LEZ1
resolver
uniprot
A0ABK0LWR3
resolver
uniprot_entry
A0A8I6AH74_RAT
resolver
uniprot_entry
A0ABK0LEZ1_RAT
resolver
uniprot_entry
A0ABK0LWR3_RAT
resolver
uniprot_entry
NEMO_RAT
resolver
amino_acid_sequence
MSRHLWKNQLSEMVQPSGGPAEDQDMLGEESSLGKPAMLHLPSEQGTPETLQRCLEENQELRDAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEKLDLRRQREQALEDLEHLKKCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKERQTLEGRIRAVSEQVRQLESEREVLQQQHSVQVDQLRMQNQSVEAALRMERQAASEEKRKLAQLQAAYHQLFQDYDSHIKSSKGMQLEDLRQQLQQAEEALVAKQELIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERHAREKLVERKELLQEQLEQLQREFNKLKVGCHESARIEDMRKRHVETSQPPLLPAPAHHSFHLALSNQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
uniprot
proteins
function
FUNCTION: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways. Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. {ECO:0000250|UniProtKB:Q9Y6K9}.
uniprot
proteins
mass_dalton
48066
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-68 attenuates aminoterminal homodimerization. {ECO:0000250|UniProtKB:Q9Y6K9}.; PTM: Polyubiquitinated on Lys-278 via 'Lys-63'-linked ubiquitin; the ubiquitination is mediated downstream of NOD2 and RIPK2 and probably plays a role in signaling by facilitating interactions with ubiquitin domain-containing proteins and activates the NF-kappa-B pathway. Polyubiquitinated on Lys-278 and Lys-302 through 'Lys-63'-linked ubiquitin; the ubiquitination is mediated by BCL10, MALT1 and TRAF6 and probably plays a role in signaling by facilitating interactions with ubiquitin domain-containing proteins and activates the NF-kappa-B pathway. Monoubiquitinated on Lys-270 and Lys-302; promotes nuclear export. Polyubiquitinated through 'Lys-27' by TRIM23; involved in antiviral innate and inflammatory responses. Linear polyubiquitinated on Lys-111, Lys-143, Lys-226, Lys-246, Lys-270, Lys-278, Lys-285, Lys-295, Lys-302 and Lys-319; the head-to-tail polyubiquitination is mediated by the LUBAC complex and plays a key role in NF-kappa-B activation. Deubiquitinated by USP10 in a TANK-dependent and -independent manner, leading to the negative regulation of NF-kappa-B signaling upon DNA damage. Ubiquitinated at Lys-319 by MARCHF2 following bacterial and viral infection which leads to its degradation. Polyubiquitinated via 'Lys-29'-linked ubiquitin; leading to lysosomal degradation. {ECO:0000250|UniProtKB:Q9Y6K9}.; PTM: Sumoylated on Lys-270 and Lys-302 with SUMO1; the modification results in phosphorylation of Ser-85 by ATM leading to a replacement of the sumoylation by mono-ubiquitination on these residues. {ECO:0000250|UniProtKB:Q9Y6K9}.; PTM: Neddylated by TRIM40, resulting in stabilization of NFKBIA and down-regulation of NF-kappa-B activity. {ECO:0000250|UniProtKB:Q9Y6K9}.
uniprot
proteins
pubmed
12968033
uniprot
proteins
sequence_length
412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y6K9}. Nucleus {ECO:0000250|UniProtKB:Q9Y6K9}. Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress. {ECO:0000250|UniProtKB:Q9Y6K9}.
uniprot
proteins