MCM7
entrez
4176
canonical
uniprot
P33993
canonical
ensembl
ENSG00000166508
resolver
ensp
ENSP00000307288
resolver
ensp
ENSP00000411295
resolver
ensp
ENSP00000518500
resolver
ensp
ENSP00000518502
resolver
enst
ENST00000425308
resolver
enst
ENST00000710813
resolver
enst
ENST00000710815
resolver
genesymbol
MCM7
resolver
genesymbol_syn
CDC47
resolver
genesymbol_syn
MCM2
resolver
hgnc
HGNC:6950
resolver
uniprot
A0A0S2Z4A5
resolver
uniprot
A4D2A1
resolver
uniprot
A4D2A2
resolver
uniprot
C6EMX8
resolver
uniprot
C9J8M6
resolver
uniprot
E9PGN9
resolver
uniprot
Q15076
resolver
uniprot
Q96D34
resolver
uniprot
Q96GL1
resolver
uniprot_entry
A0A0S2Z4A5_HUMAN
resolver
uniprot_entry
C6EMX8_HUMAN
resolver
uniprot_entry
C9J8M6_HUMAN
resolver
uniprot_entry
MCM7_HUMAN
resolver
uniprot_sec
A4D2A1
resolver
uniprot_sec
A4D2A2
resolver
uniprot_sec
E9PGN9
resolver
uniprot_sec
Q15076
resolver
uniprot_sec
Q96D34
resolver
uniprot_sec
Q96GL1
resolver
amino_acid_sequence
MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVRSPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV
uniprot
proteins
ec_number
3.6.4.12
uniprot
proteins
function
FUNCTION: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}.
uniprot
proteins
mass_dalton
81308
uniprot
proteins
post_translational_modification
PTM: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. {ECO:0000269|PubMed:22967762}.; PTM: Ubiquitinated by ECS(LRR1) E3 ubiquitin-protein ligase complex when forks converge following formation of DNA interstrand cross-links. During mitosis, ubiquitinated by TRAIP when forks converge following formation of DNA interstrand cross-links (By similarity). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase (By similarity). {ECO:0000250|UniProtKB:Q61881, ECO:0000250|UniProtKB:Q91876}.
uniprot
proteins
protein_family
MCM family
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15210935
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15538388
uniprot
proteins
pubmed
16899510
uniprot
proteins
pubmed
17116885
uniprot
proteins
pubmed
17296731
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22967762
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23711367
uniprot
proteins
pubmed
25661590
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28191891
uniprot
proteins
pubmed
32453425
uniprot
proteins
pubmed
34694004
uniprot
proteins
pubmed
34700328
uniprot
proteins
pubmed
35585232
uniprot
proteins
pubmed
7842741
uniprot
proteins
pubmed
8265339
uniprot
proteins
pubmed
8626784
uniprot
proteins
pubmed
9305914
uniprot
proteins
sequence_length
719
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000305|PubMed:35585232}.
uniprot
proteins