Noct
entrez
310395
canonical
uniprot
Q9ET55
canonical
ensembl
ENSRNOG00000010799
resolver
ensembl
ENSRNOG00055023550
resolver
ensembl
ENSRNOG00060000850
resolver
ensembl
ENSRNOG00065025920
resolver
ensp
ENSRNOP00000014348
resolver
ensp
ENSRNOP00055032873
resolver
ensp
ENSRNOP00060000352
resolver
ensp
ENSRNOP00065036591
resolver
enst
ENSRNOT00000014348
resolver
enst
ENSRNOT00055040469
resolver
enst
ENSRNOT00060001047
resolver
enst
ENSRNOT00065044680
resolver
genesymbol
Noct
resolver
genesymbol_syn
Ccr4
resolver
genesymbol_syn
Ccrn4l
resolver
genesymbol_syn
Noc
resolver
uniprot
G3V7F4
resolver
uniprot_entry
NOCT_RAT
resolver
uniprot_sec
G3V7F4
resolver
amino_acid_sequence
MYQSPRRLCSALLLRDAPGLRRTLVPGPRRTLAPPVLGSRPASPQLQAAASGAARSRPRTVSPMGNGTSRLYSALAKTINSSAAAQHPEYLVSADPEHLEPIDPKELLEECRAVLHTRPPRYQRDFVDLRTDCSSSHPPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQSRFKLINSTNIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITEGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSAYKLLSPDGQSEPPYTTWKIRTSGECRHTLDYIWYSRHALSVTSALDLLTEEQIGPNRLPSFHYPSDHLSLVCDFSFNEEPDELL
uniprot
proteins
ec_number
3.1.3.108
uniprot
proteins
function
FUNCTION: Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (By similarity). Shows a small preference for NADPH over NADP(+) (By similarity). Represses translation and promotes degradation of target mRNA molecules (By similarity). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity). {ECO:0000250|UniProtKB:O35710, ECO:0000250|UniProtKB:Q9UK39}.
uniprot
proteins
mass_dalton
48122
uniprot
proteins
protein_family
CCR4/nocturin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
428
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O35710}. Nucleus {ECO:0000250|UniProtKB:O35710}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O35710}. Mitochondrion {ECO:0000250|UniProtKB:Q9UK39}.
uniprot
proteins