Dapk2
entrez
13143
canonical
uniprot
Q8VDF3
canonical
ensembl
ENSMUSG00000032380
resolver
ensp
ENSMUSP00000034944
resolver
ensp
ENSMUSP00000158747
resolver
enst
ENSMUST00000238682
resolver
genesymbol
Dapk2
resolver
genesymbol_syn
DAPK2
resolver
uniprot
A0A571BF39
resolver
uniprot
E9JGN0
resolver
uniprot
O88861
resolver
uniprot
Q9QYM4
resolver
uniprot_entry
A0A571BF39_MOUSE
resolver
uniprot_entry
DAPK2_MOUSE
resolver
uniprot_entry
E9JGN0_MOUSE
resolver
uniprot_sec
O88861
resolver
uniprot_sec
Q9QYM4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Regulated by a double locking mechanism, involving autophosphorylation at Ser-318, calmodulin binding, and dimerization. In the inactive state, Ser-318 is phosphorylated, and the kinase is dimeric. Activation involves: dephosphorylation at Ser-318, release-of-autoinhibition mechanism where calmodulin binding induces a conformational change that relieves the steric block of the active site by the autoinhibitory domain, and generation of the monomeric active form of the kinase. {ECO:0000269|PubMed:21497605}.
uniprot
proteins
amino_acid_sequence
MVQASMRSPNMETFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDTQQAMVRRESVVNLENFKKQYVRRRWKLSFSIVSLCNHLTRSLMKKVHLRTSEDLRNCESDTEENIARRKALHPRRRSSTS
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity). Regulates granulocytes motility by controlling cell spreading and polarization (PubMed:24163421). {ECO:0000250|UniProtKB:Q9UIK4, ECO:0000269|PubMed:24163421}.
uniprot
proteins
mass_dalton
42778
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to activated Fas and TNF receptors. {ECO:0000250|UniProtKB:Q9UIK4}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
DAP kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10376525
uniprot
proteins
pubmed
10629061
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21408167
uniprot
proteins
pubmed
21497605
uniprot
proteins
pubmed
24163421
uniprot
proteins
pubmed
24906443
uniprot
proteins
pubmed
26047703
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, autophagosome lumen {ECO:0000250}.
uniprot
proteins