PNOC
entrez
5368
canonical
uniprot
Q13519
canonical
ensembl
ENSG00000168081
resolver
ensp
ENSP00000301908
resolver
ensp
ENSP00000430145
resolver
ensp
ENSP00000763904
resolver
ensp
ENSP00000763905
resolver
genesymbol
PNOC
resolver
genesymbol_syn
OFQ
resolver
hgnc
HGNC:9163
resolver
uniprot
B7Z749
resolver
uniprot
Q6FH16
resolver
uniprot_entry
PNOC_HUMAN
resolver
uniprot_sec
B7Z749
resolver
uniprot_sec
Q6FH16
resolver
amino_acid_sequence
MKVLLCDLLLLSLFSSVFSSCQRDCLTCQEKLHPALDSFDLEVCILECEEKVFPSPLWTPCTKVMARSSWQLSPAAPEHVAAALYQPRASEMQHLRRMPRVRSLFQEQEEPEPGMEEAGEMEQKQLQKRFGGFTGARKSARKLANQKRFSEFMRQYLVLSMQSSQRRRTLHQNGNV
uniprot
proteins
function
FUNCTION: [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. {ECO:0000250|UniProtKB:P55791}.; FUNCTION: [Nocistatin]: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia. {ECO:0000250|UniProtKB:O62647}.; FUNCTION: [Orphanin FQ2]: Has potent analgesic activity. {ECO:0000250|UniProtKB:Q64387}.
uniprot
proteins
mass_dalton
20295
uniprot
proteins
post_translational_modification
PTM: Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.; PTM: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
uniprot
proteins
protein_family
Opioid neuropeptide precursor family
uniprot
proteins
pubmed
12950177
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8710928
uniprot
proteins
pubmed
8710930
uniprot
proteins
pubmed
9168905
uniprot
proteins
sequence_length
176
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins