PICALM
entrez
8301
canonical
uniprot
Q13492
canonical
ensembl
ENSG00000073921
resolver
ensp
ENSP00000348718
resolver
ensp
ENSP00000377015
resolver
ensp
ENSP00000433846
resolver
ensp
ENSP00000434884
resolver
ensp
ENSP00000436958
resolver
ensp
ENSP00000560445
resolver
ensp
ENSP00000560446
resolver
ensp
ENSP00000560447
resolver
ensp
ENSP00000560448
resolver
ensp
ENSP00000560449
resolver
ensp
ENSP00000560450
resolver
ensp
ENSP00000560453
resolver
ensp
ENSP00000560454
resolver
ensp
ENSP00000560455
resolver
ensp
ENSP00000560456
resolver
ensp
ENSP00000560457
resolver
ensp
ENSP00000560458
resolver
ensp
ENSP00000560460
resolver
ensp
ENSP00000560472
resolver
ensp
ENSP00000647079
resolver
ensp
ENSP00000693679
resolver
ensp
ENSP00000693681
resolver
genesymbol
PICALM
resolver
genesymbol_syn
CALM
resolver
hgnc
HGNC:15514
resolver
uniprot
B4DTM3
resolver
uniprot
E9PN05
resolver
uniprot
F8VPG7
resolver
uniprot
O60700
resolver
uniprot
Q4LE54
resolver
uniprot
Q6GMQ6
resolver
uniprot
Q86XZ9
resolver
uniprot_entry
PICAL_HUMAN
resolver
uniprot_sec
B4DTM3
resolver
uniprot_sec
E9PN05
resolver
uniprot_sec
F8VPG7
resolver
uniprot_sec
O60700
resolver
uniprot_sec
Q4LE54
resolver
uniprot_sec
Q6GMQ6
resolver
uniprot_sec
Q86XZ9
resolver
amino_acid_sequence
MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQIQFM
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving PICALM is found in diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with MLLT10. {ECO:0000269|PubMed:8643484}.
uniprot
proteins
function
FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}.
uniprot
proteins
mass_dalton
70755
uniprot
proteins
protein_family
PICALM/SNAP91 family
uniprot
proteins
pubmed
10436022
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16262731
uniprot
proteins
pubmed
16491119
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21808019
uniprot
proteins
pubmed
22118466
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23741335
uniprot
proteins
pubmed
24067654
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25241929
uniprot
proteins
pubmed
25898166
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27574975
uniprot
proteins
pubmed
8643484
uniprot
proteins
pubmed
9737689
uniprot
proteins
sequence_length
652
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16262731}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:10436022}. Golgi apparatus {ECO:0000269|PubMed:10436022}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:10436022}. Nucleus {ECO:0000269|PubMed:16491119}. Note=Colocalized with clathrin in the Golgi area (PubMed:10436022). Interaction with PIMREG may target PICALM to the nucleus in some cells (PubMed:16491119). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16491119}.
uniprot
proteins