RRM2
entrez
6241
canonical
uniprot
P31350
canonical
ensembl
ENSG00000171848
resolver
ensp
ENSP00000302955
resolver
ensp
ENSP00000353770
resolver
genesymbol
RRM2
resolver
genesymbol_syn
RR2
resolver
hgnc
HGNC:10452
resolver
uniprot
B2R9B5
resolver
uniprot
J3KP43
resolver
uniprot
Q5WRU7
resolver
uniprot_entry
RIR2_HUMAN
resolver
uniprot_sec
B2R9B5
resolver
uniprot_sec
J3KP43
resolver
uniprot_sec
Q5WRU7
resolver
amino_acid_sequence
MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF
uniprot
proteins
ec_number
1.17.4.1
uniprot
proteins
function
FUNCTION: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
uniprot
proteins
mass_dalton
44878
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="S->A: Enhances inhibitory effect on Wnt signaling."; MUTAGEN 20; /note="S->E: Prevents inhibitory effect on Wnt signaling."; MUTAGEN 33; /note="T->A: Strongly reduces the interaction with CCNF. Lack of proteasomal degradation. Increase in the cellular concentration of dATP and dGTP, but not dCTP and dTTP, leading to an imbalance in dNTP pools and genome instability."; /evidence="ECO:0000269|PubMed:22632967"; MUTAGEN 49..51; /note="RRI->ARA: Abolishes the interaction with CCNF. Lack of proteasomal degradation. Increase in the cellular concentration of dATP and dGTP, but not dCTP and dTTP, leading to an imbalance in dNTP pools and genome instability."; /evidence="ECO:0000269|PubMed:22632967
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling. Phosphorylated on Thr-33 by CDK1 and CDK2; predominantly in G2 and M phase (PubMed:22632967). {ECO:0000269|PubMed:22632967}.; PTM: Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex; leading to its degradation by the proteasome. {ECO:0000269|PubMed:22632967}.
uniprot
proteins
protein_family
Ribonucleoside diphosphate reductase small chain family
uniprot
proteins
pubmed
11978970
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
1627826
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22632967
uniprot
proteins
sequence_length
389
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22632967}. Nucleus {ECO:0000269|PubMed:22632967}. Note=Localized to the cytoplasm in S phase cells. May localize to the nucleus in G2 phase cells. {ECO:0000269|PubMed:22632967}.
uniprot
proteins