Ffar2
entrez
292794
canonical
uniprot
Q76EI6
canonical
ensembl
ENSRNOG00000021021
resolver
ensembl
ENSRNOG00055032419
resolver
ensembl
ENSRNOG00060031916
resolver
ensembl
ENSRNOG00065033395
resolver
ensp
ENSRNOP00000028532
resolver
ensp
ENSRNOP00000092741
resolver
ensp
ENSRNOP00055046140
resolver
ensp
ENSRNOP00055046144
resolver
ensp
ENSRNOP00060045789
resolver
ensp
ENSRNOP00060045792
resolver
ensp
ENSRNOP00065047252
resolver
ensp
ENSRNOP00065047253
resolver
enst
ENSRNOT00000028532
resolver
enst
ENSRNOT00000110584
resolver
enst
ENSRNOT00055055984
resolver
enst
ENSRNOT00055055988
resolver
enst
ENSRNOT00060055345
resolver
enst
ENSRNOT00060055348
resolver
enst
ENSRNOT00065057411
resolver
enst
ENSRNOT00065057412
resolver
genesymbol
Ffar2
resolver
genesymbol_syn
Gpr43
resolver
uniprot_entry
FFAR2_RAT
resolver
amino_acid_sequence
MTPDWHSSLILTAYILIFLTGLPANLLALRAFVSRVRQPQPAPVHILLLNLTLADLLLLLLLPFRIVEAASNFRWYLPKIVCALTGFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWIMSFGHCTIVIIVQYLNSTEQVGTENQITCYENFTQAQLDVVLPVRLELCLVLFFVPMTVTIFCYWRFVWIMLTQPHVGAQRRRRAVGLAVVTLLNFLVCFGPYNMSHLVGFHLRQSPSWRVEAVVFSSLNASLDPLLFYFSSSVVRRAFGKGLLLLRNPGSSMLGRGAEETVEGTKTDRGGSQTEGAQSSDFVTE
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes. {ECO:0000269|PubMed:23589301}.
uniprot
proteins
mass_dalton
36994
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
16453106
uniprot
proteins
pubmed
23589301
uniprot
proteins
sequence_length
330
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 44..64; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 80..100; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 185..205; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 220..240; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 256..276; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins