NR0B2
entrez
8431
canonical
uniprot
Q15466
canonical
ensembl
ENSG00000131910
resolver
ensp
ENSP00000254227
resolver
ensp
ENSP00000772530
resolver
enst
ENST00000254227
resolver
genesymbol
NR0B2
resolver
genesymbol_syn
SHP
resolver
hgnc
HGNC:7961
resolver
uniprot
F1D8P5
resolver
uniprot
Q5QP36
resolver
uniprot_entry
NR0B2_HUMAN
resolver
uniprot_sec
F1D8P5
resolver
uniprot_sec
Q5QP36
resolver
amino_acid_sequence
MSTSQPGACPCQGAASRPAILYALLSSSLKAVPRPRSRCLCRQHRPVQLCAPHRTCREALDVLAKTVAFLRNLPSFWQLPPQDQRRLLQGCWGPLFLLGLAQDAVTFEVAEAPVPSILKKILLEEPSSSGGSGQLPDRPQPSLAAVQWLQCCLESFWSLELSPKEYACLKGTILFNPDVPGLQAASHIGHLQQEAHWVLCEVLEPWCPAAQGRLTRVLLTASTLKSIPTSLLGDLFFRPIIGDVDIAGLLGDMLLLR
uniprot
proteins
disease_involvement
DISEASE: Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269|PubMed:11136233}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (PubMed:22504882). Specifically inhibits transactivation of the nuclear receptor with which it interacts (PubMed:22504882). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (PubMed:14752053). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity). {ECO:0000250|UniProtKB:Q62227, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:22504882}.
uniprot
proteins
mass_dalton
28058
uniprot
proteins
post_translational_modification
PTM: Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors. {ECO:0000250|UniProtKB:Q62227}.
uniprot
proteins
protein_family
NR0 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
11136233
uniprot
proteins
pubmed
14752053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15723037
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21262773
uniprot
proteins
pubmed
22504882
uniprot
proteins
pubmed
28128295
uniprot
proteins
pubmed
28797635
uniprot
proteins
pubmed
8650544
uniprot
proteins
pubmed
9603951
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:28797635}. Cytoplasm {ECO:0000269|PubMed:14752053}. Note=Colocalizes with NEUROD1 in the nucleus.
uniprot
proteins