Cd38
entrez
25668
canonical
uniprot
Q64244
canonical
ensembl
ENSRNOG00000003069
resolver
ensembl
ENSRNOG00055015136
resolver
ensembl
ENSRNOG00060019019
resolver
ensembl
ENSRNOG00065005575
resolver
ensp
ENSRNOP00000004121
resolver
ensp
ENSRNOP00055021124
resolver
ensp
ENSRNOP00060026919
resolver
ensp
ENSRNOP00065005789
resolver
enst
ENSRNOT00055025910
resolver
enst
ENSRNOT00060032921
resolver
enst
ENSRNOT00065008260
resolver
genesymbol
Cd38
resolver
uniprot_entry
CD38_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Both NAADP and cADPR synthesis are inhibited by nicotinic acid. {ECO:0000305|PubMed:11829748}.
uniprot
proteins
amino_acid_sequence
MANYEFSQVSEDRPGCRLTRKAQIGLGVGLLLLVALVVVVVIVLWPRSPLVWKGKPTTKHFADIILGRCLIYTQILRPEMRDQDCKKILSTFKRGFISKNPCNITNEDYAPLVKLVTQTIPCNKTLFWSKSKHLAHQYTWIQGKMFTLEDTLLGYIADDLRWCGDPSTSDMNYDSCPHWSENCPNNPVAVFWNVISQKFAEDACGVVQVMLNGSLSEPFYRNSTFGSVEVFNLDPNKVHKLQAWVMHDIKGTSSNACSSPSINELKSIVNKRNMIFACQDNYRPVRFLQCVKNPEHPSCRLNV
uniprot
proteins
ec_number
2.4.99.20
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: Multifunctional transmembrane glycoprotein able to exert enzymatic activities and also to mobilize calcium, to transduce signals, to adhere to hyaluronan and to other ligands. Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid (PubMed:11829748). At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity. Functions also as a receptor that binds the ligand CD31 on endothelial cells, promoting lymphocyte activation, proliferation, and migration across the endothelial barrier. Involved in the regulation of crucial dendritic cell functions acquired at the mature stage, such as CCL21-driven migration, survival, and Th1-polarizing activity. In lamina propria T lymphocytes, CD38/CD31 cognate interactions initiate a multistep signaling pathway resulting in activation of LCK anf LAT, followed by cytokine release. {ECO:0000250|UniProtKB:P28907, ECO:0000269|PubMed:11829748}.; FUNCTION: Regulates osteoclastic bone resorption, probably via production of cyclic ADP-ribose and triggering of a cytosolic calcium ion signal through ryanodine receptor activation. {ECO:0000269|PubMed:10477767}.
uniprot
proteins
mass_dalton
34436
uniprot
proteins
protein_family
ADP-ribosyl cyclase family
uniprot
proteins
pubmed
10477767
uniprot
proteins
pubmed
11829748
uniprot
proteins
pubmed
8037769
uniprot
proteins
pubmed
8061050
uniprot
proteins
sequence_length
303
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10477767, ECO:0000305|PubMed:11829748}; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 22..44; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins