Skap1
entrez
286975
canonical
uniprot
Q4V7G1
canonical
ensembl
ENSRNOG00000023881
resolver
ensp
ENSRNOP00000033594
resolver
ensp
ENSRNOP00000080687
resolver
enst
ENSRNOT00000030159
resolver
enst
ENSRNOT00000095547
resolver
genesymbol
Skap1
resolver
genesymbol_syn
Scap1
resolver
genesymbol_syn
Skap55
resolver
uniprot
A0A8I5ZTK3
resolver
uniprot
Q8CHI6
resolver
uniprot_entry
A0A8I5ZTK3_RAT
resolver
uniprot_entry
SKAP1_RAT
resolver
uniprot_sec
Q8CHI6
resolver
amino_acid_sequence
MQAIALPEEICWLLEDAEDFLAEGLQNENLSPGAQDQRDHILRGFQQIKSRYCWDFQPQGDDLGQDGSDENLSGTHGPALASDASFWSDYQEEGIDDIIRGAQELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVISRGLFLYYANEKSKQPKGTFLIKGYNVRMAPHLRKDSKKDSCFELTSQDRRSYEFTAFSPAEARDWVDQISFLLKDLSSLTIPFEEEEEEEEEDKEQEEMYNDIDGFDSARSGSQGRAMALPEPLDKEEDVYEVLPDEDDLEEDACGAHRRRVDYADYYQGLWDCHGDQPDELSFQRGDLIRILSKEYNMYGWWVGELNSIIGIVPKDYLTTAFEMEGR
uniprot
proteins
function
FUNCTION: Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway (By similarity). Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (PubMed:12681493). {ECO:0000250|UniProtKB:Q86WV1, ECO:0000269|PubMed:12681493}.
uniprot
proteins
mass_dalton
40903
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-267 is required for GRB2 interaction (By similarity). Phosphorylation by FYN on Tyr-290 abolishes interaction with FYB1. Tyr-236 is dephosphorylated by PTPRC (By similarity). {ECO:0000250|UniProtKB:Q86WV1}.
uniprot
proteins
protein_family
SKAP family
uniprot
proteins
pubmed
12681493
uniprot
proteins
pubmed
15199160
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86WV1}. Nucleus {ECO:0000250|UniProtKB:Q86WV1}. Cell membrane {ECO:0000250|UniProtKB:Q86WV1}. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane. {ECO:0000250|UniProtKB:Q86WV1}.
uniprot
proteins