SLC25A17
entrez
10478
canonical
uniprot
O43808
canonical
ensembl
ENSG00000100372
resolver
ensp
ENSP00000390722
resolver
ensp
ENSP00000438355
resolver
enst
ENST00000435456
resolver
enst
ENST00000544408
resolver
genesymbol
SLC25A17
resolver
genesymbol_syn
PMP34
resolver
hgnc
HGNC:10987
resolver
uniprot
A8KA59
resolver
uniprot
B4DP73
resolver
uniprot
B4DU97
resolver
uniprot
F6RTR7
resolver
uniprot
Q5TFL0
resolver
uniprot
Q9UGW8
resolver
uniprot
Q9UGY7
resolver
uniprot_entry
B4DP73_HUMAN
resolver
uniprot_entry
B4DU97_HUMAN
resolver
uniprot_entry
F6RTR7_HUMAN
resolver
uniprot_entry
PM34_HUMAN
resolver
uniprot_sec
A8KA59
resolver
uniprot_sec
Q5TFL0
resolver
uniprot_sec
Q9UGW8
resolver
uniprot_sec
Q9UGY7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by pyridoxal 5'-phosphate and bathophenanthroline. {ECO:0000269|PubMed:22185573}.
uniprot
proteins
amino_acid_sequence
MASVLSYESLVHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKEEGLLAPYRGWFPVISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPAIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKLTAATFTVMGLKRAHQH
uniprot
proteins
function
FUNCTION: Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. {ECO:0000269|PubMed:22185573}.
uniprot
proteins
mass_dalton
34567
uniprot
proteins
mutagenesis
MUTAGEN 190..199; /note="KRQLLKKRMK->AAQLLAAAMA: Localizes in the cytoplasm."; /evidence="ECO:0000269|PubMed:11121399"; MUTAGEN 283..285; /note="LMF->KKK: Impairs interaction with PEX19."; /evidence="ECO:0000269|PubMed:14709540"; MUTAGEN 289..290; /note="EK->LL: Impairs interaction with PEX19."; /evidence="ECO:0000269|PubMed:14709540"; MUTAGEN 302..303; /note="KR->EE: No effect on interaction with PEX19."; /evidence="ECO:0000269|PubMed:14709540
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10704444
uniprot
proteins
pubmed
11121399
uniprot
proteins
pubmed
11402059
uniprot
proteins
pubmed
12445829
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14709540
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22185573
uniprot
proteins
pubmed
9874197
uniprot
proteins
sequence_length
307
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14709540}. Peroxisome membrane {ECO:0000269|PubMed:11121399, ECO:0000269|PubMed:11402059, ECO:0000269|PubMed:14709540, ECO:0000269|PubMed:9874197}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 67..87; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 281..301; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins