Srrt
entrez
83701
canonical
uniprot
Q99MR6
canonical
ensembl
ENSMUSG00000037364
resolver
ensp
ENSMUSP00000142564
resolver
ensp
ENSMUSP00000143232
resolver
ensp
ENSMUSP00000196233
resolver
genesymbol
Srrt
resolver
genesymbol_syn
Ars2
resolver
genesymbol_syn
Asr2
resolver
uniprot
Q3UD04
resolver
uniprot
Q5D042
resolver
uniprot
Q8VEE6
resolver
uniprot
Q99MR4
resolver
uniprot
Q99MR5
resolver
uniprot
Q99MR7
resolver
uniprot_entry
SRRT_MOUSE
resolver
uniprot_sec
Q3UD04
resolver
uniprot_sec
Q5D042
resolver
uniprot_sec
Q8VEE6
resolver
uniprot_sec
Q99MR4
resolver
uniprot_sec
Q99MR5
resolver
uniprot_sec
Q99MR7
resolver
amino_acid_sequence
MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYDMPYAGGGGGPTYGPPQPWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPIMKSFKEFLLSLDDSVDETEAVKRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLKVFLSLMESGWFDNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKTGEASKKEEARAGPALGEGERKANDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEEAEKEAKKSKKRNRKQSGDDSFDEGSVSESESESEGGQAEEEKEEAEEALKEKEKPKEEEKEKPKDAAGLECKPRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASEPGTPPVPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGPPPEEPPKEGNPAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPGLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF
uniprot
proteins
function
FUNCTION: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription. {ECO:0000269|PubMed:19632182, ECO:0000269|PubMed:22198669}.
uniprot
proteins
mass_dalton
100452
uniprot
proteins
protein_family
ARS2 family
uniprot
proteins
pubmed
11239002
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18086880
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19632182
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22198669
uniprot
proteins
sequence_length
875
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way.
uniprot
proteins