FDX1
entrez
2230
canonical
uniprot
P10109
canonical
ensembl
ENSG00000137714
resolver
ensp
ENSP00000260270
resolver
enst
ENST00000260270
resolver
genesymbol
FDX1
resolver
genesymbol_syn
ADX
resolver
hgnc
HGNC:3638
resolver
uniprot
B0YJ14
resolver
uniprot
Q53YD6
resolver
uniprot_entry
ADX_HUMAN
resolver
uniprot_sec
B0YJ14
resolver
uniprot_sec
Q53YD6
resolver
amino_acid_sequence
MAAAGGARLLRAASAVLGGPAGRWLHHAGSRAGSSGLLRNRGPGGSAEASRSLSVSARARSSSEDKITVHFINRDGETLTTKGKVGDSLLDVVVENNLDIDGFGACEGTLACSTCHLIFEDHIYEKLDAITDEENDMLDLAYGLTDRSRLGCQICLTKSMDNMTVRVPETVADARQSIDVGKTS
uniprot
proteins
function
FUNCTION: Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). {ECO:0000250|UniProtKB:P00257, ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:21636783}.
uniprot
proteins
mass_dalton
19393
uniprot
proteins
protein_family
Adrenodoxin/putidaredoxin family
uniprot
proteins
pubmed
12699818
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
1909889
uniprot
proteins
pubmed
20547883
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21636783
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2340092
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2969697
uniprot
proteins
pubmed
3229285
uniprot
proteins
pubmed
3343244
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:20547883}.
uniprot
proteins