Fzd6
entrez
14368
canonical
uniprot
Q61089
canonical
ensembl
ENSMUSG00000022297
resolver
ensp
ENSMUSP00000022906
resolver
ensp
ENSMUSP00000136328
resolver
ensp
ENSMUSP00000247281
resolver
ensp
ENSMUSP00000247284
resolver
ensp
ENSMUSP00000247285
resolver
ensp
ENSMUSP00000247286
resolver
enst
ENSMUST00000022906
resolver
enst
ENSMUST00000179165
resolver
genesymbol
Fzd6
resolver
uniprot
Q3UTZ0
resolver
uniprot
Q542J1
resolver
uniprot_entry
FZD6_MOUSE
resolver
uniprot_entry
Q3UTZ0_MOUSE
resolver
uniprot_entry
Q542J1_MOUSE
resolver
amino_acid_sequence
MERSPFLLACILLPLVRGHSLFTCEPITVPRCMKMTYNMTFFPNLMGHYDQGIAAVEMGHFLHLANLECSPNIEMFLCQAFIPTCTEQIHVVLPCRKLCEKIVSDCKKLMDTFGIRWPEELECNRLPHCDDTVPVTSHPHTELSGPQKKSDQVPRDIGFWCPKHLRTSGDQGYRFLGIEQCAPPCPNMYFKSDELDFAKSFIGIVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFVGFLLGNSTACNKADEKLELGDTVVLGSKNKACSVVFMFLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGAPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYELVNRITWEMTWFSDHCHQYRIPCPYQANPKARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHGAPGPHRLKVISKSMGTSTGATTNHGTSAMAIADHDYLGQETSTEVHTSPEASVKEGRADRANTPSAKDRDCGESAGPSSKLSGNRNGRESRAGGLKERSNGSEGAPSEGRVSPKSSVPETGLIDCSTSQAASSPEPTSLKGSTSLPVHSASRARKEQGAGSHSDA
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. Activation by Wnt5A stimulates PKC activity via a G protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (By similarity). Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. {ECO:0000250, ECO:0000269|PubMed:16495441}.
uniprot
proteins
mass_dalton
79082
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
10097073
uniprot
proteins
pubmed
10395542
uniprot
proteins
pubmed
16495441
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21665003
uniprot
proteins
pubmed
31073040
uniprot
proteins
pubmed
8626800
uniprot
proteins
sequence_length
709
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10097073}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:10097073}; Multi-pass membrane protein {ECO:0000255}. Cell surface {ECO:0000269|PubMed:16495441}. Apical cell membrane {ECO:0000269|PubMed:16495441}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:16495441}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:31073040}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with FZD3 at the apical face of cells (PubMed:16495441). Localizes to the endoplasmic reticulum membrane in the presence of LMBR1L (PubMed:31073040). {ECO:0000269|PubMed:16495441, ECO:0000269|PubMed:31073040}.
uniprot
proteins
transmembrane_region
TRANSMEM 202..222; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 234..254; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 285..305; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 325..345; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 371..391; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 417..437; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 474..494; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins