D3ZDX9
uniprot
D3ZDX9
canonical
amino_acid_sequence
MHACEGSAAGRRAFDSICPNRMLDLSRRSLGKPGKPERKFVPPWKSFPGCGGGSPVSVYEDPLDAEPAPLPALTTIDLQDLADCTSLLGTEAPPSGDSPASQNPSLQTEADFNLQNFRDAVDDLIADSSSLTSPPLTDGDFPFSPCDVPSFGSCLSPSLDPPALGSPHLPPPPTEQYWKEVADQNQRALGTALIENNQLHVTLTQKQEEIASLRERNVQLKELACRTRHLASVLDKLMITQSPAEPFQLKATTKRSLEELFSATGQAGQGCAEVDAILRDISQRCEEALQNRDPKRPRLQQEPDSKDCSTRNLHGVFRGLRTDCGASSVNLSHSELEEGGSFSTPIRSHSTIRTLAFPQGKAFTIRTVTGGYKFRWVPS
uniprot
proteins
function
FUNCTION: Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1. {ECO:0000250|UniProtKB:D6RGH6, ECO:0000250|UniProtKB:Q08B36}.
uniprot
proteins
mass_dalton
41162
uniprot
proteins
protein_family
Geminin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:D6RGH6}. Note=Excluded from the nucleolus. {ECO:0000250|UniProtKB:D6RGH6}.
uniprot
proteins