Cldn4
entrez
12740
canonical
uniprot
O35054
canonical
ensembl
ENSMUSG00000047501
resolver
ensp
ENSMUSP00000053420
resolver
enst
ENSMUST00000051401
resolver
genesymbol
Cldn4
resolver
genesymbol_syn
Cper
resolver
genesymbol_syn
Cpetr1
resolver
uniprot
Q3UM35
resolver
uniprot_entry
CLD4_MOUSE
resolver
uniprot_entry
Q3UM35_MOUSE
resolver
amino_acid_sequence
MASMGLQVLGISLAVLGWLGIILSCALPMWRVTAFIGSNIVTAQTSWEGLWMNCVVQSTGQMQCKMYDSMLALPQDLQAARALMVISIIVGALGMLLSVVGGKCTNCMEDETVKAKIMITAGAVFIVASMLIMVPVSWTAHNVIRDFYNPMVASGQKREMGASLYVGWAASGLLLLGGGLLCCSCPPRSNDKPYSAKYSAARSVPASNYV
uniprot
proteins
function
FUNCTION: Can associate with other claudins to regulate tight junction structural and functional strand dynamics (By similarity) (PubMed:20921420, PubMed:35773259). May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (PubMed:20921420, PubMed:25831548). May integrate into CLDN3 strands to modulate localized tight junction barrier properties (By similarity). May disrupt strand assembly of channel-forming CLDN2 and CLDN15 and inhibit cation conductance. Cannot form tight junction strands on its own (By similarity). {ECO:0000250|UniProtKB:O14493, ECO:0000269|PubMed:20921420, ECO:0000269|PubMed:25831548, ECO:0000269|PubMed:35773259}.
uniprot
proteins
mass_dalton
22339
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="R->T: No effect."; /evidence="ECO:0000269|PubMed:20921420"; MUTAGEN 48; /note="E->Q: No effect."; /evidence="ECO:0000269|PubMed:20921420"; MUTAGEN 65; /note="K->T: Abolishes ability to form paracellular chloride channel."; /evidence="ECO:0000269|PubMed:20921420"; MUTAGEN 68; /note="D->N: No effect."; /evidence="ECO:0000269|PubMed:20921420"; MUTAGEN 76; /note="D->N: No effect."; /evidence="ECO:0000269|PubMed:20921420
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1 (By similarity). {ECO:0000250|UniProtKB:O14493}.
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
10601346
uniprot
proteins
pubmed
16236711
uniprot
proteins
pubmed
20921420
uniprot
proteins
pubmed
25831548
uniprot
proteins
pubmed
30734065
uniprot
proteins
pubmed
35773259
uniprot
proteins
pubmed
9334247
uniprot
proteins
pubmed
9892664
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:20921420, ECO:0000269|PubMed:25831548, ECO:0000269|PubMed:30734065, ECO:0000269|PubMed:9892664}. Cell membrane {ECO:0000269|PubMed:20921420, ECO:0000269|PubMed:9892664}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins