DUSP3
entrez
1845
canonical
uniprot
P51452
canonical
ensembl
ENSG00000108861
resolver
ensp
ENSP00000226004
resolver
genesymbol
DUSP3
resolver
genesymbol_syn
VHR
resolver
hgnc
HGNC:3069
resolver
uniprot
D3DX45
resolver
uniprot
Q5U0J1
resolver
uniprot
Q8IYJ9
resolver
uniprot_entry
DUS3_HUMAN
resolver
uniprot_sec
D3DX45
resolver
uniprot_sec
Q5U0J1
resolver
uniprot_sec
Q8IYJ9
resolver
amino_acid_sequence
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines (PubMed:10224087, PubMed:11863439). Specifically dephosphorylates and inactivates ERK1 and ERK2 (PubMed:10224087, PubMed:11863439). {ECO:0000269|PubMed:10224087, ECO:0000269|PubMed:11863439}.
uniprot
proteins
mass_dalton
20478
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
10224087
uniprot
proteins
pubmed
11863439
uniprot
proteins
pubmed
1281549
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19888758
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
27346674
uniprot
proteins
pubmed
27941812
uniprot
proteins
pubmed
8650541
uniprot
proteins
sequence_length
185
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10224087, ECO:0000269|PubMed:27346674}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9D7X3}.
uniprot
proteins