MTNR1A
entrez
4543
canonical
uniprot
P48039
canonical
ensembl
ENSG00000168412
resolver
ensp
ENSP00000302811
resolver
ensp
ENSP00000515216
resolver
enst
ENST00000307161
resolver
enst
ENST00000703170
resolver
genesymbol
MTNR1A
resolver
hgnc
HGNC:7463
resolver
uniprot
A0AVC5
resolver
uniprot
B0M0L2
resolver
uniprot_entry
MTR1A_HUMAN
resolver
uniprot_sec
A0AVC5
resolver
uniprot_sec
B0M0L2
resolver
amino_acid_sequence
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
uniprot
proteins
function
FUNCTION: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Possibly involved in sleep induction, by melatonin activation of the potassium channel KCNMA1/BK and the dissociation of G-beta and G-gamma subunits, thereby decreasing synaptic transmission (By similarity). {ECO:0000250|UniProtKB:Q61184}.
uniprot
proteins
mass_dalton
39375
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10471411
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
31019306
uniprot
proteins
pubmed
7946354
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 64..84; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 188..208; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 275..295; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins