Ddhd2
entrez
72108
canonical
uniprot
Q80Y98
canonical
ensembl
ENSMUSG00000061313
resolver
ensp
ENSMUSP00000033975
resolver
ensp
ENSMUSP00000147859
resolver
ensp
ENSMUSP00000298694
resolver
ensp
ENSMUSP00000298697
resolver
ensp
ENSMUSP00000298700
resolver
ensp
ENSMUSP00000298703
resolver
enst
ENSMUST00000211688
resolver
genesymbol
Ddhd2
resolver
genesymbol_syn
Kiaa0725
resolver
genesymbol_syn
Samwd1
resolver
uniprot
A0A1B0GSA5
resolver
uniprot
E9QKK2
resolver
uniprot
Q0VF66
resolver
uniprot
Q6A008
resolver
uniprot
Q9CVE9
resolver
uniprot_entry
A0A1B0GSA5_MOUSE
resolver
uniprot_entry
DDHD2_MOUSE
resolver
uniprot_sec
E9QKK2
resolver
uniprot_sec
Q0VF66
resolver
uniprot_sec
Q6A008
resolver
uniprot_sec
Q9CVE9
resolver
amino_acid_sequence
MSSGESHQEQLSQSDPSPSPNSCSSFELIDMDASSSYEPVSPHWFYCKVLDSKELWIPFNSEDSQQLEDAYGSGKDCNERIVPTDGGRYDVHLGERMRYAVYWDELPSEVRRCTWFYKGDKDNKYVPYSESFSQVLEDTYMLAVTLDEWKKKIESPNREIIVLHNPKLMVHYQPIAGSDEWGSTSTEQGRPRSVKRGVENIPVDIHCGEPLQIDHLVFVVHGIGPACDLRFRSIVQCVNDFRSVSLNLLQTHFKKAQENEQIGRVEFLPVNWHSPLHSTGVDIDLQRITLPSINRLRHFTNDTILDVFFYNSPTYCQTIVDTVASEMNRIYTLFLQRNPDFKGGVSIAGHSLGSLILFDILTNQKNSIGDIDSEKGSLSSAEDRGDASTLEEDLKKLQLSEFVTVFEKEKVDREALALCTDRDLQEMGIPLGPRKKILNHFSARKNSVSINRPAMSASEVNISKENGDYLDVGIGQVSVKYPRLNYKPEIFFAFGSPIGMFLTVRGLRRIDPNYKFPTCKGFFNIYHPFDPVAYRIEPMVAPGIEFEPMLIPHHKGRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKSFTRGPYPALQASETAEETEAEPESSSEKSNEANTEEPPVEVKEEAPISVGMLNGGQRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTVLLVLKEIYQTQGVFLDQPLQ
uniprot
proteins
ec_number
3.1.1.-
uniprot
proteins
ec_number
3.1.1.3
uniprot
proteins
function
FUNCTION: Diacylglycerol (DAG) and triacylglycerol (TAG) lipase that is required for proper lipid homeostasis in the central nervous system (PubMed:25267624, PubMed:37832604). It cooperates with PNPLA2/ATGL in neuronal TAG catabolism and hydrolyzes sn-1,3-DAG downstream of PNPLA2/ATGL (PubMed:37832604). In vitro, also acts as a phospholipase that hydrolyzes preferentially phosphatidic acids, including 1,2-dioleoyl-sn-phosphatidic acid, phosphatidylcholine and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:25267624, ECO:0000269|PubMed:37832604}.
uniprot
proteins
mass_dalton
79577
uniprot
proteins
mutagenesis
MUTAGEN 351; /note="S->A: Loss of TAG hydrolase activity."; /evidence="ECO:0000269|PubMed:25267624
uniprot
proteins
protein_family
PA-PLA1 family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25267624
uniprot
proteins
pubmed
37832604
uniprot
proteins
sequence_length
699
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Golgi apparatus, cis-Golgi network {ECO:0000250}. Note=Cycles between the Golgi apparatus and the cytosol. DDHD2 recruitment to the Golgi/endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is regulated by the levels of phosphoinositides, including PI(4)P (By similarity). {ECO:0000250}.
uniprot
proteins