Slc38a4
entrez
69354
canonical
uniprot
Q8R1S9
canonical
ensembl
ENSMUSG00000022464
resolver
ensp
ENSMUSP00000023101
resolver
ensp
ENSMUSP00000127676
resolver
ensp
ENSMUSP00000154818
resolver
ensp
ENSMUSP00000155158
resolver
ensp
ENSMUSP00000163318
resolver
enst
ENSMUST00000023101
resolver
enst
ENSMUST00000166223
resolver
enst
ENSMUST00000230086
resolver
enst
ENSMUST00000231039
resolver
genesymbol
Slc38a4
resolver
genesymbol_syn
Ata3
resolver
genesymbol_syn
Nat3
resolver
genesymbol_syn
Snat4
resolver
uniprot
Q3TEZ9
resolver
uniprot
Q3TJ89
resolver
uniprot
Q3TPL5
resolver
uniprot
Q8VIE7
resolver
uniprot_entry
S38A4_MOUSE
resolver
uniprot_sec
Q3TEZ9
resolver
uniprot_sec
Q3TJ89
resolver
uniprot_sec
Q3TPL5
resolver
uniprot_sec
Q8VIE7
resolver
amino_acid_sequence
MDPMELNNVSIEPDGDSCSGDSIQDSYTGMENSDKDAMNSQFANEDAESQKFLTNGFLGKKKLADYADEHHPGMTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLTVAILSLYSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFISITMQNIGAMSSYLFIIKYELPEVIRAFMGLEENTGEWYLNGNYLVLFVSVGIILPLSLLKNLGYLGYTSGFSLSCMVFFVSVVIYKKFQIPCPLPALDHNNGNLTFNNTLPIHMISLPNDSESSGVNFMMDYAHHNPAGLDEKQVAGPLHSNGVEYEAQGAEKCQPKYFVFNSRTAYAIPILAFAFVCHPEVLPIYSELKDRSRRKMQTVSNISISGMLVMYLLAALFGYLSFYGDVEDELLHAYSKVYTFDTALLMVRLAVLVAVTLTVPIVLFPIRTSVITLLFPRKPFSWLKHFGIAAIIIALNNILVILVPTIKYIFGFIGASSATMLIFILPAAFYLKLVKKEPLRSPQKIGALVFLVTGIIFMMGSMALIILDWIYNPPNPNHH
uniprot
proteins
function
FUNCTION: Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:12537539, PubMed:23301202, PubMed:23451088). The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+) (PubMed:12537539). Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L-proline and L-glutamine and L-methionine (By similarity). {ECO:0000250|UniProtKB:Q969I6, ECO:0000250|UniProtKB:Q9EQ25, ECO:0000269|PubMed:12537539, ECO:0000269|PubMed:23301202, ECO:0000269|PubMed:23451088}.
uniprot
proteins
mass_dalton
60464
uniprot
proteins
mutagenesis
MUTAGEN 18; /note="C->A: No significant effect on alanine uptake."; /evidence="ECO:0000269|PubMed:23451088"; MUTAGEN 232; /note="C->A: 40% decrease in alanine uptake. Significantly decreases alanine transporter activity. Does not affect cell surface expression."; /evidence="ECO:0000269|PubMed:23301202, ECO:0000269|PubMed:23451088"; MUTAGEN 249; /note="C->A: Abolishes transport activity."; /evidence="ECO:0000269|PubMed:23451088"; MUTAGEN 321; /note="C->A: Abolishes transport activity."; /evidence="ECO:0000269|PubMed:23451088"; MUTAGEN 345; /note="C->A: No significant effect on alanine uptake. Does not affect alanine transport activity.
uniprot
proteins
post_translational_modification
PTM: The disulfide bond plays an important role in substrate transport, but has no effect on trafficking to the cell surface. {ECO:0000269|PubMed:23451088}.
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
pubmed
11820791
uniprot
proteins
pubmed
12537539
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23301202
uniprot
proteins
pubmed
23451088
uniprot
proteins
pubmed
31570606
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12537539, ECO:0000269|PubMed:23451088}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q969I6}. Cell projection, microvillus membrane {ECO:0000250|UniProtKB:Q969I6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q969I6}. Note=Microvillus membrane localization in placenta. {ECO:0000250|UniProtKB:Q969I6}.
uniprot
proteins
transmembrane_region
TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 152..172; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 221..241; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 333..353; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 370..390; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 412..432; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 454..474; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 477..497; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 515..535; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins