IFNL2
entrez
282616
canonical
uniprot
Q8IZJ0
canonical
ensembl
ENSG00000183709
resolver
ensembl
ENSG00000291875
resolver
ensp
ENSP00000333639
resolver
ensp
ENSP00000517479
resolver
enst
ENST00000331982
resolver
enst
ENST00000709041
resolver
genesymbol
IFNL2
resolver
genesymbol_syn
IL28A
resolver
genesymbol_syn
ZCYTO20
resolver
hgnc
HGNC:18364
resolver
uniprot
Q45KQ8
resolver
uniprot
Q6VN55
resolver
uniprot
Q8IWL7
resolver
uniprot_entry
IFNL2_HUMAN
resolver
uniprot_sec
Q45KQ8
resolver
uniprot_sec
Q6VN55
resolver
uniprot_sec
Q8IWL7
resolver
amino_acid_sequence
MKLDMTGDCTPVLVLMAAVLTVTGAVPVARLHGALPDARGCHIAQFKSLSPQELQAFKRAKDALEESLLLKDCRCHSRLFPRTWDLRQLQVRERPMALEAELALTLKVLEATADTDPALVDVLDQPLHTLHHILSQFRACIQPQPTAGPRTRGRLHHWLYRLQEAPKKESPGCLEASVTFNLFRLLTRDLNCVASGDLCV
uniprot
proteins
function
FUNCTION: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210, ECO:0000269|PubMed:16539846}.
uniprot
proteins
mass_dalton
22288
uniprot
proteins
protein_family
Type-III (or lambda) interferon family
uniprot
proteins
pubmed
12469119
uniprot
proteins
pubmed
12483210
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16146571
uniprot
proteins
pubmed
16539846
uniprot
proteins
pubmed
20712453
uniprot
proteins
pubmed
24751921
uniprot
proteins
sequence_length
200
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12483210}.
uniprot
proteins