Tyrp1
entrez
22178
canonical
uniprot
P07147
canonical
ensembl
ENSMUSG00000005994
resolver
ensp
ENSMUSP00000006151
resolver
ensp
ENSMUSP00000099895
resolver
enst
ENSMUST00000006151
resolver
enst
ENSMUST00000102831
resolver
genesymbol
Tyrp1
resolver
genesymbol_syn
Tyrp-1
resolver
uniprot
Q3UFS3
resolver
uniprot_entry
Q3UFS3_MOUSE
resolver
uniprot_entry
TYRP1_MOUSE
resolver
amino_acid_sequence
MKSYNVLPLAYISLFLMLFYQVWAQFPRECANIEALRRGVCCPDLLPSSGPGTDPCGSSSGRGRCVAVIADSRPHSRHYPHDGKDDREAWPLRFFNRTCQCNDNFSGHNCGTCRPGWRGAACNQKILTVRRNLLDLSPEEKSHFVRALDMAKRTTHPQFVIATRRLEDILGPDGNTPQFENISVYNYFVWTHYYSVKKTFLGTGQESFGDVDFSHEGPAFLTWHRYHLLQLERDMQEMLQEPSFSLPYWNFATGKNVCDVCTDDLMGSRSNFDSTLISPNSVFSQWRVVCESLEEYDTLGTLCNSTEGGPIRRNPAGNVGRPAVQRLPEPQDVTQCLEVRVFDTPPFYSNSTDSFRNTVEGYSAPTGKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYAYEVQWPGQEFTVSEIITIAVVAALLLVAAIFGVASCLIRSRSTKNEANQPLLTDHYQRYAEDYEELPNPNHSMV
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Tyrp1 are the cause of the brown (b) phenotype. Brown mice have a brown or hypopigmented coat. {ECO:0000269|PubMed:2245916}.
uniprot
proteins
ec_number
1.14.18.-
uniprot
proteins
function
FUNCTION: Plays a role in melanin biosynthesis (PubMed:2245916). Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid (PubMed:7813420). May regulate or influence the type of melanin synthesized (PubMed:2245916, PubMed:7813420). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (PubMed:1537333). {ECO:0000269|PubMed:1537333, ECO:0000269|PubMed:2245916, ECO:0000269|PubMed:7813420}.
uniprot
proteins
mass_dalton
60761
uniprot
proteins
pathway_participation
PATHWAY: Pigment biosynthesis; melanin biosynthesis. {ECO:0000269|PubMed:2245916}.
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:1537333}.
uniprot
proteins
protein_family
Tyrosinase family
uniprot
proteins
pubmed
1537333
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1693779
uniprot
proteins
pubmed
17182842
uniprot
proteins
pubmed
18650808
uniprot
proteins
pubmed
2245916
uniprot
proteins
pubmed
26620560
uniprot
proteins
pubmed
3008090
uniprot
proteins
pubmed
3132713
uniprot
proteins
pubmed
35469906
uniprot
proteins
pubmed
7813420
uniprot
proteins
pubmed
8270621
uniprot
proteins
sequence_length
537
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:18650808, ECO:0000269|PubMed:26620560}; Single-pass type I membrane protein {ECO:0000269|PubMed:17182842}. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:26620560}.
uniprot
proteins
transmembrane_region
TRANSMEM 478..501; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins