Pgrmc1
entrez
53328
canonical
uniprot
O55022
canonical
ensembl
ENSMUSG00000006373
resolver
ensp
ENSMUSP00000073061
resolver
enst
ENSMUST00000073339
resolver
genesymbol
Pgrmc1
resolver
genesymbol_syn
Pgrmc
resolver
uniprot
Q3TXU8
resolver
uniprot
Q99JN0
resolver
uniprot_entry
PGRC1_MOUSE
resolver
uniprot_entry
Q3TXU8_MOUSE
resolver
uniprot_sec
Q99JN0
resolver
amino_acid_sequence
MAAEDVVATGADPSELEGGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPGASGDNDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTPAQQETLSDWDSQFTFKYHHVGKLLKEGEEPTVYSDDEEPKDETARKNE
uniprot
proteins
function
FUNCTION: Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (PubMed:28005395). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (By similarity). {ECO:0000250|UniProtKB:O00264, ECO:0000269|PubMed:27599036, ECO:0000269|PubMed:28005395}.
uniprot
proteins
mass_dalton
21694
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains chondroitin sulfate attached to Ser-54. Ser-54 is in the cytoplasmic domain but the glycosylated form was detected in urine, suggesting that the membrane-bound form is cleaved, allowing for production of a secreted form which is glycosylated. {ECO:0000250|UniProtKB:O00264}.
uniprot
proteins
protein_family
Cytochrome b5 family
uniprot
proteins
protein_family
MAPR subfamily
uniprot
proteins
pubmed
15378723
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17208939
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27599036
uniprot
proteins
pubmed
28005395
uniprot
proteins
pubmed
31748741
uniprot
proteins
sequence_length
195
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:Q95250}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O00264}; Single-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000269|PubMed:27599036}; Single-pass membrane protein {ECO:0000305}; Extracellular side {ECO:0000269|PubMed:27599036}. Secreted {ECO:0000250|UniProtKB:O00264}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..43; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins