Ptprq
entrez
237523
canonical
uniprot
P0C5E4
canonical
ensembl
ENSMUSG00000035916
resolver
ensp
ENSMUSP00000058572
resolver
enst
ENSMUST00000050702
resolver
genesymbol
Ptprq
resolver
uniprot_entry
PTPRQ_MOUSE
resolver
amino_acid_sequence
MDFLFFFLFSLIGTSESQVDVSGSFDDTVYDITLSSISATTYSSPVSRTLATNVSKPGPPVFLAGERVGSAGILLSWNTPPNPNGRIISYVVKYKEVCPWMQTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEALNYSAVNLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIKVEDLLSGKLPECNENSDSFLWSTTSPSPTLSRATPPLRTTHLSNTLARNKISSVWKEPISFVVTHLRPYTTYLFEVSAVTTEAGYIDSTIVRTPESVPEGPPQNCITGNVTGKAFSISWDPPAIVTGKFSYRVELYGPTGRILDNSTKDLRFVFTHLTPFTMYDVYVAAETSAGVGPKSNLSVFTPPDVPGAVFDLQIVEVEATEIRVSWRKPRQPNGIISQYRVKVSVLESGVILENTLLTGQDEYINNPMTPEIMNLVDPMIGFYEGSGEMSSDLHSLASFIYNSHPHDFPARTRVEDQRSPVVATRNQYMTDIAAEHLSYVIRRLVPFTEHTISVSAFTVMGEGPPTVLTVRTREQVPSSIQIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQMTTVDNSFLITGLKKYTRYKMRVAASTHVGESSLSEENDLFVRTPEDEPESSPQDVKVTDVSPSELSLTWSPPEKPNGIIIAYEVFYQNADALFVKNTSTTNITLSDLKPYTLYNISIQSYTRLGHGNQSSSLLSVRTSETVPDSAPENITYKNISSEEIEIFFLPPRSPNGIIQKYTIYLKRSNSHEARTIETTSLTLTIGGLKKYTHYVIEVSASTLKGEGVRSMPISILTEEDAPDSPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDKVSLKTINATEVSLELSDLDYHADYSAYVTASTRFGDGKTRSSVINFRTPEGEPSDPPKDVHYVNLSSSSIILFWTPPVKPNGIIQYYSVYYQNTSSTFVQNFTLLEVTQEPGNVTVSARIYKLAVFSYYTFWLTASTLVGNGNKSSDVIHVYTDQDIPEGGVGNLTYESLSSTAINVSWTPPSQPNGLVFYYVSLNLQQSPPRHRRPPLTTYENSIYFDNLEKYTDYIFKITPSTEKGFSETYTAQLHIKTEEDVPDTPPIINTFKNLSSTSILLSWDPPLKPNGAILSYHLTLQGTHANRTFVTSGNHIVLEELSPFTLYSFLAAARTMKGLGPSSILFFYTDESAPLAPPQNLTLINYTSDFVWLTWSPSPLPGGIVKVYSFKIHEHETDTVFYKNISGFQTDAKLAGLEPVSTYSISVSAFTKVGNGNQFSNVVKFTTQESVPDAVQNIACVARDWQSVSVMWDPPRKANGIIIHYMITVEGNSTKVSPRDPMYTFTKLLANTSYIFEVRASTSAGEGNESQCNVSTLPETVPSVPTNTAFSNVQSTSVTLRWIKPDTILGYFQNYKITTQLRAQKCREWEPEECVEHQEVQYLYEANQTEDTVRGLKKFQWYRFQVAASTNAGYGNASSWISTQTLPGPPDGPPENVRVVATSPFGINISWNEPAIITGPTFYLIDVKSVDNDNFNISFVKSNEENKTTEINDLEVFTRYSVVITAFVGNVSGAYTDGKSSAEVIITTLESVPKDPPNNMTFQKIPDEVTKFQLSFLPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTDTSVIAMLEGLKGGHTYNISVYAINSAGAGPKVQMRITMDIKAPARPKTKPIPIHDATGKLLVTSTTITIRMPICYYNDDHGPIRNVQVLVAEAGAQQDGNVTKWYDAYFNKARPYFTNEGFPNPPCIEGKTKFSGNEEIYVIGADNACMIPGNEEKICNGPLKPKKQYLFKFRATNVMGQFTDSEYSDPIKTLGEGLSERTVEIILSVTLCILSIILLGTAIFAFARIRQKQKEGGTYSPRDAEIIDTKFKLDQLITVADLELKDERLTRLLSYRKSIKPVSKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADVSIPGSDYINASYVSGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDILITKLMEDIQIDWTIRDLKIERHGDCMTVRQCNFTGWPEHGVPENTTPLIHFVKLVRTSRAHDATPMVVHCSAGVGRTGVFIALDHLTQHIHDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGGHQPVCFVNYSTLQKMDSLDAMEGDVELEWEETTM
uniprot
proteins
ec_number
3.1.3.36
uniprot
proteins
ec_number
3.1.3.67
uniprot
proteins
ec_number
3.1.3.86
uniprot
proteins
ec_number
3.1.3.95
uniprot
proteins
function
FUNCTION: Dephosphorylates phosphatidylinositol phosphates, such as phosphatidylinositol 3,4,5-trisphosphate (PIP3) and phosphatidylinositol 3,5-diphosphates, with preference for PIP3. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity in vitro; however, the relevance of such activity in vivo is unclear (By similarity). Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by regulating the levels of PIP3 in MSCs and preadipocyte cells (By similarity). Required for hair bundle maturation, a process that enables hair cells to detect and transmit sound and balance signals effectively, therefore affecting auditory function (PubMed:14534255). May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles (Probable). {ECO:0000250|UniProtKB:O88488, ECO:0000250|UniProtKB:Q9UMZ3, ECO:0000269|PubMed:14534255, ECO:0000305|PubMed:14534255}.
uniprot
proteins
mass_dalton
256785
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 2A subfamily
uniprot
proteins
pubmed
14534255
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24285636
uniprot
proteins
pubmed
37952086
uniprot
proteins
sequence_length
2300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, stereocilium {ECO:0000269|PubMed:24285636, ECO:0000269|PubMed:37952086}. Apical cell membrane {ECO:0000269|PubMed:24285636}; Single-pass type I membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000250|UniProtKB:Q9UMZ3}; Single-pass type I membrane protein {ECO:0000255}. Note=Detected at the stereocilium base and at the apical cell membrane in mature hair cells (PubMed:24285636). Forms ring-like structures in the stereocilium taper region (PubMed:37952086). Detected at the basal cell membrane in fetal kidney podocytes (By similarity). {ECO:0000250|UniProtKB:Q9UMZ3, ECO:0000269|PubMed:24285636, ECO:0000269|PubMed:37952086}.
uniprot
proteins
transmembrane_region
TRANSMEM 1907..1927; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins