Slc38a5
entrez
192208
canonical
uniprot
A2VCW5
canonical
ensembl
ENSRNOG00000027767
resolver
ensembl
ENSRNOG00055022355
resolver
ensembl
ENSRNOG00060022262
resolver
ensembl
ENSRNOG00065011778
resolver
ensp
ENSRNOP00000038781
resolver
ensp
ENSRNOP00000073818
resolver
enst
ENSRNOT00000038068
resolver
genesymbol
Slc38a5
resolver
genesymbol_syn
Sn2
resolver
genesymbol_syn
Snat5
resolver
uniprot
A0A0H2UHW1
resolver
uniprot
Q91XR7
resolver
uniprot_entry
A0A0H2UHW1_RAT
resolver
uniprot_entry
S38A5_RAT
resolver
uniprot_sec
Q91XR7
resolver
activity_regulation
ACTIVITY REGULATION: Not inhibited by lithium (By similarity). Partial allosteric regulation on ions sodium binding (PubMed:16629640). {ECO:0000250|UniProtKB:Q8WUX1, ECO:0000269|PubMed:16629640}.
uniprot
proteins
amino_acid_sequence
MAISCAVGMEMQEPKMNGTLSTGAAAGYRQEREGFLPTTHGPAPGRKPVQFLDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCASVVGIRAYEQLGQRAFGPAGKVVVAIIICLHNVGAMSSYLFIIKSELPLVIGTFLHMDPEGDWFLKGNLLIILVSLLIILPLALMKHLGYLGYTSSLSLTCMLFFLISVIYKKFQLGCVVSHNDTVVESEPAPLQAFNSSCEAKLFTVDSQMSYTVPIMAFAFVCHPEVLPIYTELCCPTQRRMQAVANMSIGAMFIMYGLTATFGYLTFYSTVKAEMLEMYTQEDLLILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPSKAFSWPRHVAIALILLILVNILVICVPTIRDIFGFIGSTSAPSLIFILPSVFYLRIVPADMEPLFSWPKIQALCFGVLGVLFMAISLGFMFANWATGQSRMSGH
uniprot
proteins
function
FUNCTION: Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:11698233, PubMed:15218073, PubMed:16249471, PubMed:16629640, PubMed:22821889). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-glutamine cycle and the NMDA receptors activation (PubMed:22821889). In addition contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells and, therefore participates in the retinal glutamate-glutamine cycle (PubMed:16249471). The transport activity is pH sensitive (PubMed:22821889, PubMed:15218073, PubMed:11698233), Li(+) tolerant (PubMed:22821889, PubMed:15218073, PubMed:11698233), bidirectional (PubMed:22821889, PubMed:15218073) and associated with large uncoupled fluxes of protons (PubMed:11698233, PubMed:15218073, PubMed:22821889). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (PubMed:22821889). May have particular importance for modulation of net hepatic glutamine flux (PubMed:15218073). {ECO:0000269|PubMed:11698233, ECO:0000269|PubMed:15218073, ECO:0000269|PubMed:16249471, ECO:0000269|PubMed:16629640, ECO:0000269|PubMed:22821889}.
uniprot
proteins
mass_dalton
52436
uniprot
proteins
mutagenesis
MUTAGEN 479; /note="H->A: Modifies the transporter pH-sensitivity."; /evidence="ECO:0000269|PubMed:16629640
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
pubmed
11698233
uniprot
proteins
pubmed
15218073
uniprot
proteins
pubmed
15390093
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16249471
uniprot
proteins
pubmed
16629640
uniprot
proteins
pubmed
22821889
uniprot
proteins
pubmed
24333324
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15390093, ECO:0000269|PubMed:22821889}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at astroglial membrane. {ECO:0000269|PubMed:22821889}.
uniprot
proteins
transmembrane_region
TRANSMEM 59..81; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 98..118; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 303..323; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 342..362; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 384..404; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 447..467; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins