MIF
entrez
4282
canonical
uniprot
P14174
canonical
ensembl
ENSG00000240972
resolver
ensembl
ENSG00000276701
resolver
ensp
ENSP00000215754
resolver
ensp
ENSP00000482779
resolver
enst
ENST00000215754
resolver
enst
ENST00000613839
resolver
genesymbol
MIF
resolver
genesymbol_syn
GLIF
resolver
genesymbol_syn
MMIF
resolver
hgnc
HGNC:7097
resolver
uniprot
A5Z1R8
resolver
uniprot
B2R4S3
resolver
uniprot
I4AY87
resolver
uniprot
Q2V4Y5
resolver
uniprot
Q6FHV0
resolver
uniprot_entry
I4AY87_HUMAN
resolver
uniprot_entry
MIF_HUMAN
resolver
uniprot_sec
A5Z1R8
resolver
uniprot_sec
B2R4S3
resolver
uniprot_sec
Q2V4Y5
resolver
uniprot_sec
Q6FHV0
resolver
amino_acid_sequence
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
uniprot
proteins
disease_involvement
DISEASE: Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. {ECO:0000269|PubMed:11508429}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
5.3.2.1
uniprot
proteins
ec_number
5.3.3.12
uniprot
proteins
function
FUNCTION: Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens (PubMed:15908412, PubMed:17443469, PubMed:23776208). The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense (PubMed:15908412, PubMed:17443469, PubMed:23776208). Counteracts the anti-inflammatory activity of glucocorticoids (PubMed:15908412, PubMed:17443469, PubMed:23776208). Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known (PubMed:11439086, PubMed:17526494). It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (PubMed:11439086, PubMed:17526494). {ECO:0000269|PubMed:11439086, ECO:0000269|PubMed:15908412, ECO:0000269|PubMed:17443469, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:23776208}.
uniprot
proteins
mass_dalton
12476
uniprot
proteins
mutagenesis
MUTAGEN 111; /note="N->C: Causes formation of interchain disulfide bonds with Cys-81 from another subunit."; /evidence="ECO:0000269|PubMed:23776208
uniprot
proteins
protein_family
MIF family
uniprot
proteins
pubmed
10353846
uniprot
proteins
pubmed
11089976
uniprot
proteins
pubmed
11170644
uniprot
proteins
pubmed
11439086
uniprot
proteins
pubmed
11508429
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12681488
uniprot
proteins
pubmed
12782713
uniprot
proteins
pubmed
1286669
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15908412
uniprot
proteins
pubmed
17443469
uniprot
proteins
pubmed
17526494
uniprot
proteins
pubmed
19090677
uniprot
proteins
pubmed
19454686
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23776208
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2552447
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7679497
uniprot
proteins
pubmed
7683862
uniprot
proteins
pubmed
7947826
uniprot
proteins
pubmed
8188240
uniprot
proteins
pubmed
8234256
uniprot
proteins
pubmed
8610159
uniprot
proteins
pubmed
8643551
uniprot
proteins
pubmed
8766818
uniprot
proteins
sequence_length
115
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15908412, ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:2552447, ECO:0000269|PubMed:8234256}. Cytoplasm {ECO:0000269|PubMed:11089976, ECO:0000269|PubMed:19454686}. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. {ECO:0000269|PubMed:15908412}.
uniprot
proteins