Cln8
entrez
26889
canonical
uniprot
Q9QUK3
canonical
ensembl
ENSMUSG00000026317
resolver
ensp
ENSMUSP00000027554
resolver
ensp
ENSMUSP00000315915
resolver
ensp
ENSMUSP00000315916
resolver
enst
ENSMUST00000027554
resolver
genesymbol
Cln8
resolver
uniprot
Q542J5
resolver
uniprot_entry
CLN8_MOUSE
resolver
uniprot_entry
Q542J5_MOUSE
resolver
amino_acid_sequence
MTPVSSHGLAESIFDLDYASWKIRSTLAVAGFVFYLGVFVVCHQLSSSLNATYRSLAAKEKVFWNLAATRAVFGVQSTTAGLWALLGDPVLYADKALGQQNWCWFHITTATGFFFFENVAVHLSNLFFRTFDLFLVVHHLFAFLGFLGSAINLRAGHYLAMTTLLLEMSTPFTCISWMLLKAGWSDSLFWKANQWLMIHMFHCRMILTYHMWWVCFCHWDALTSSLHLPHWALFLFGLALLTAVINPYWTHKKTQQLLHPVDWNFAQEEAKGSRQERTNGQVPRKKRL
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Cln8 are the cause of the phenotype motor neuron degeneration (mnd). Mnd is a naturally occurring mutant It is characterized by progressive motor system degeneration. It has intracellular autofluorescent inclusions similar to those seen in human Cln8. {ECO:0000269|PubMed:10508524}.
uniprot
proteins
function
FUNCTION: Could play a role in cell proliferation during neuronal differentiation and in protection against cell death. {ECO:0000250|UniProtKB:Q9UBY8}.
uniprot
proteins
mass_dalton
33109
uniprot
proteins
pubmed
10508524
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19941651
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UBY8}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q9UBY8}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:19941651}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 131..151; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins