Cd5
entrez
54236
canonical
uniprot
P51882
canonical
ensembl
ENSRNOG00000020872
resolver
ensp
ENSRNOP00000051697
resolver
enst
ENSRNOT00000054812
resolver
genesymbol
Cd5
resolver
uniprot
A0A8L2QP90
resolver
uniprot
Q63098
resolver
uniprot_entry
A0A8L2QP90_RAT
resolver
uniprot_entry
CD5_RAT
resolver
uniprot_sec
Q63098
resolver
amino_acid_sequence
MDSHEVLLAATYLLGTLAAFCLGQSGRGFVGAQVMLSGSNSKCQGLVEVQMNGMKTVCSSSWRLSQDLWKNANEASTVCQQLGCGNPLALGHLTLWNRPKNQILCQGPPWSFSNCSTSSLGQCLPLSLVCLEPQKTTPLPTTTLPTTMPEPTAPPRLQLVPGHEGLRCTGVVEFYNGSRGGTILYKAKARPVDLGNLICKSLQCGSFLTHLSRIETAGTPAPAELRDPRPLPIRWEAQNGSCTSLQQCFQKTTVQEGSQALAVVCSDFQPKVQSRLVGGSSVCEGIAEVRQRSQWAALCDSSAARGPGRWEELCQEQQCGNLISFHVMDADRTSPGVLCTQEKLSQCYQLQKKTHCKRVFITCKDPNPVGLAPGTVASIILTLVLLVVLMVMCGPLIYKKLVKKFRQKKQRQWIGPTGVNQSMSFHRSHTATVRSQVENPAASHVDNEYSQPPRNSRLSAYPALEGALHRSSTQPDNSSDSDYDLQVAQRL
uniprot
proteins
function
FUNCTION: Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (By similarity). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (By similarity). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (By similarity). {ECO:0000250|UniProtKB:P06127, ECO:0000250|UniProtKB:P13379}.
uniprot
proteins
mass_dalton
53440
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine, threonine and tyrosine residues following TCR stimulation. Phosphorylated by LCK on Tyr-449 and Tyr-483 upon TCR engagement. {ECO:0000250|UniProtKB:P06127, ECO:0000250|UniProtKB:P13379}.
uniprot
proteins
pubmed
7510236
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P13379}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P13379}.
uniprot
proteins
transmembrane_region
TRANSMEM 369..398; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins