Eme2
entrez
193838
canonical
uniprot
Q56A04
canonical
ensembl
ENSMUSG00000073436
resolver
ensp
ENSMUSP00000113936
resolver
enst
ENSMUST00000121542
resolver
genesymbol
Eme2
resolver
uniprot_entry
EME2_MOUSE
resolver
amino_acid_sequence
MAEVGPGRVTVSRLGRGLRLGHRRPQTWEISDSDGEGVPAREVGTQAPSPAGERRAAAKALRADQVLGRLVVCVDPAVLEDAGSDILMEALGTLGCECRIEPQHQARSLQWNVVRPDPAPSNVPLEAKAENEQEQLLLLEPQEFLQGAAQLTQITDPPCSIPWLSPKSLTRSHLAVIGLDAYLWSHQLSSQKTWQLKKSKEAHARGAISWAEVEEILVLLQLHANLDVLLMASWQELSQYVCAFTRALSQLPSKQHRDSQAFSFCTAGHWASGQQVTRDGSGLRGVWWRQIRQFNRVSPAVADAVVTAFPSPRLLQQALLDCSTEQERLSLLADLPVKAHKGKQPRRVGPDLSRRICIFLTTTNPDLLLDLSS
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of the structure-specific, heterodimeric DNA endonuclease MUS81-EME2 which is involved in the maintenance of genome stability. In the complex, EME2 is required for DNA cleavage, participating in DNA recognition and bending. MUS81-EME2 cleaves 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs. MUS81-EME2 which is active during the replication of DNA is more specifically involved in replication fork processing. Replication forks frequently encounter obstacles to their passage, including DNA base lesions, DNA interstrand cross-links, difficult-to-replicate sequences, transcription bubbles, or tightly bound proteins. One mechanism for the restart of a stalled replication fork involves nucleolytic cleavage mediated by the MUS81-EME2 endonuclease. By acting upon the stalled fork, MUS81-EME2 generates a DNA double-strand break (DSB) that can be repaired by homologous recombination, leading to the restoration of an active fork. MUS81-EME2 could also function in telomere maintenance. {ECO:0000250|UniProtKB:A4GXA9}.
uniprot
proteins
mass_dalton
41083
uniprot
proteins
protein_family
EME1/MMS4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A4GXA9}.
uniprot
proteins