SLC22A14
entrez
9389
canonical
uniprot
Q9Y267
canonical
ensembl
ENSG00000144671
resolver
ensp
ENSP00000273173
resolver
ensp
ENSP00000396283
resolver
enst
ENST00000273173
resolver
enst
ENST00000448498
resolver
genesymbol
SLC22A14
resolver
genesymbol_syn
OCTL2
resolver
genesymbol_syn
ORCTL4
resolver
hgnc
HGNC:8495
resolver
uniprot
A0AVS9
resolver
uniprot
A1L4H6
resolver
uniprot
B2RCX3
resolver
uniprot
Q6DJT3
resolver
uniprot_entry
S22AE_HUMAN
resolver
uniprot_sec
A0AVS9
resolver
uniprot_sec
A1L4H6
resolver
uniprot_sec
B2RCX3
resolver
uniprot_sec
Q6DJT3
resolver
amino_acid_sequence
MAGEENFKEELRSQDASRNLNQHEVAGHPHSWSLEMLLRRLRAVHTKQDDKFANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTDTCQDGWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAILSLTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQIRNKVKDMKTKETSSDDV
uniprot
proteins
function
FUNCTION: Riboflavin transporter localized at the inner mitochondrial membrane of the spermatozoa midpiece, which is required for male fertility (By similarity). SLC22A14-mediated riboflavin transport is essential for spermatozoa energy generation and motility: riboflavin is the precursor of FMN and FAD, which are coenzymes of many enzymes in the TCA cycle (the citric acid cycle) in mitochondria (By similarity). Required for sperm motility and normal sperm flagellar structure (By similarity). {ECO:0000250|UniProtKB:Q497L9}.
uniprot
proteins
mass_dalton
66684
uniprot
proteins
mutagenesis
MUTAGEN 388; /note="W->A: Strongly reduced riboflavin transport; when associated with A-395 and A-487."; /evidence="ECO:0000269|PubMed:33882315"; MUTAGEN 395; /note="Y->A: Strongly reduced riboflavin transport; when associated with A-388 and A-487."; /evidence="ECO:0000269|PubMed:33882315"; MUTAGEN 487; /note="R->A: Strongly reduced riboflavin transport; when associated with A-388 and A-395."; /evidence="ECO:0000269|PubMed:33882315
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
10072596
uniprot
proteins
pubmed
10231028
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
33882315
uniprot
proteins
sequence_length
594
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:33882315}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q497L9}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the principle piece of the sperm tail. {ECO:0000250|UniProtKB:Q497L9}.
uniprot
proteins
transmembrane_region
TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 271..291; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 298..318; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 380..400; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 409..431; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 438..458; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 489..509; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 513..533; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 539..559; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins