Ppm1d
entrez
53892
canonical
uniprot
Q9QZ67
canonical
ensembl
ENSMUSG00000020525
resolver
ensp
ENSMUSP00000020835
resolver
enst
ENSMUST00000020835
resolver
genesymbol
Ppm1d
resolver
genesymbol_syn
Wip1
resolver
uniprot
B1B0B0
resolver
uniprot
Q3TZJ9
resolver
uniprot
Q80WV2
resolver
uniprot_entry
PPM1D_MOUSE
resolver
uniprot_entry
Q3TZJ9_MOUSE
resolver
uniprot_entry
Q80WV2_MOUSE
resolver
uniprot_sec
B1B0B0
resolver
amino_acid_sequence
MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPAAEDKPAPVPRRALGLPATPTLAGVGPSEKGPAAARDPAPDAAASLPAGRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHSGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGKFVVSPEPDTSVHTLDPRKHKYIILGSDGLWNMVPPQDAISMCQDQEEKKYLMGEQGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELFLNLTDSPTYNSQETCVMTSSPSSTPPIKSPEEDAWPRLSSKDHIPALVRSNAFSEKFLEVPAEIARGNIQTVVMTSKDSETLEENCPKALTLRIHDSLNNTLSVGLIPTNSTNTIMDQKNLKMSTPGQMKAQEVERTPPANFKRTLEESNSGPLMKKHRRNGLSRSSGAQASSLPTASQRRHSVKLTLRRRLRGQRKMGNPLLHQHRKTVCVC
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation (By similarity). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (PubMed:24135283). {ECO:0000250|UniProtKB:O15297, ECO:0000269|PubMed:24135283}.
uniprot
proteins
mass_dalton
65723
uniprot
proteins
protein_family
PP2C family
uniprot
proteins
pubmed
10756097
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24135283
uniprot
proteins
sequence_length
598
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O15297}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O15297}.
uniprot
proteins