Gpr171
entrez
229323
canonical
uniprot
Q8BG55
canonical
ensembl
ENSMUSG00000050075
resolver
ensp
ENSMUSP00000082115
resolver
enst
ENSMUST00000085040
resolver
genesymbol
Gpr171
resolver
uniprot
Q8BTN1
resolver
uniprot
Q8BY85
resolver
uniprot
Q8CIF3
resolver
uniprot_entry
GP171_MOUSE
resolver
uniprot_sec
Q8BTN1
resolver
uniprot_sec
Q8BY85
resolver
uniprot_sec
Q8CIF3
resolver
amino_acid_sequence
MTNSSTFCPVYRDLEPFTYFFYLVFLIGIIGSCFATWAFIQKTTNHRCVSIYLINLLTADFLLTLALPVKIIVDLGVAPWKLRIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLIHSCKIYRIQEPGFAKMISAVVWLMVLLIMVPNMVIPIKDIKEKSNVGCMEFKKEFGRNWHLLTNFICVAIFLNFSVIILISNFLAIRQLYRNRDNTNYPSVKSALLHILLVTASYIICFVPYHAVRIPYTLSQTEVISDCSTRIALFKAKEATLLLAVSNLCFDPILYYHLSKAFRLKVTETFASPKKSKPLEERLRSENDV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N) (PubMed:24043826, PubMed:28425495). Acts through a G(i)-alpha-mediated pathway in response to Big LEN (PubMed:24043826). Big LEN-GPR171 system plays an important role in regulating feeding and metabolism (PubMed:24043826). Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala (PubMed:28425495). Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception (PubMed:31308196). Acts as a negative regulator T cell function (PubMed:34615877). {ECO:0000269|PubMed:24043826, ECO:0000269|PubMed:28425495, ECO:0000269|PubMed:31308196, ECO:0000269|PubMed:34615877}.
uniprot
proteins
mass_dalton
36720
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24043826
uniprot
proteins
pubmed
27117253
uniprot
proteins
pubmed
28425495
uniprot
proteins
pubmed
31308196
uniprot
proteins
pubmed
34615877
uniprot
proteins
sequence_length
319
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24043826, ECO:0000269|PubMed:28425495}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalized with GPR83 in the paraventricular nucleus. {ECO:0000269|PubMed:27117253}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 49..69; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 133..153; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 182..202; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins