Cryaa
entrez
12954
canonical
uniprot
P24622
canonical
ensembl
ENSMUSG00000024041
resolver
ensp
ENSMUSP00000019192
resolver
ensp
ENSMUSP00000154747
resolver
ensp
ENSMUSP00000157708
resolver
enst
ENSMUST00000228089
resolver
genesymbol
Cryaa
resolver
genesymbol_syn
Crya1
resolver
uniprot
A0A494B9Q6
resolver
uniprot
P02490
resolver
uniprot
P02496
resolver
uniprot
P82532
resolver
uniprot
Q546L9
resolver
uniprot
Q569M7
resolver
uniprot
Q61444
resolver
uniprot
Q6LEL4
resolver
uniprot_entry
A0A494B9Q6_MOUSE
resolver
uniprot_entry
CRYAA_MOUSE
resolver
uniprot_entry
Q546L9_MOUSE
resolver
uniprot_entry
Q569M7_MOUSE
resolver
uniprot_sec
P02490
resolver
uniprot_sec
P02496
resolver
uniprot_sec
P82532
resolver
uniprot_sec
Q61444
resolver
uniprot_sec
Q6LEL4
resolver
amino_acid_sequence
MDVTIQHPWFKRALGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISELMTHMWFVMHQPHAGNPKNNPVKVRSDRDKFVIFLDVKHFSPEDLTVKVLEDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFSGPKVQSGLDAGHSERAIPVSREEKPSSAPSS
uniprot
proteins
function
FUNCTION: Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. {ECO:0000250|UniProtKB:P02489}.
uniprot
proteins
mass_dalton
22489
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-93 may increase chaperone activity. {ECO:0000250|UniProtKB:P02489}.; PTM: Undergoes age-dependent proteolytical cleavage at the C-terminus. {ECO:0000250|UniProtKB:P02489}.
uniprot
proteins
protein_family
Small heat shock protein (HSP20) family
uniprot
proteins
pubmed
6187470
uniprot
proteins
pubmed
7156978
uniprot
proteins
sequence_length
196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P02489}. Nucleus {ECO:0000250|UniProtKB:P02489}. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. {ECO:0000250|UniProtKB:P02489}.
uniprot
proteins