Ptpra
entrez
19262
canonical
uniprot
P18052
canonical
ensembl
ENSMUSG00000027303
resolver
ensp
ENSMUSP00000028769
resolver
ensp
ENSMUSP00000076533
resolver
ensp
ENSMUSP00000162502
resolver
ensp
ENSMUSP00000162521
resolver
enst
ENSMUST00000028769
resolver
genesymbol
Ptpra
resolver
genesymbol_syn
Lrp
resolver
genesymbol_syn
Ptpa
resolver
uniprot
A2AHF2
resolver
uniprot
F8WGM1
resolver
uniprot
Q3TRY9
resolver
uniprot
Q61808
resolver
uniprot
Q91V35
resolver
uniprot_entry
F8WGM1_MOUSE
resolver
uniprot_entry
PTPRA_MOUSE
resolver
uniprot_entry
Q3TRY9_MOUSE
resolver
uniprot_entry
Q91V35_MOUSE
resolver
uniprot_sec
A2AHF2
resolver
uniprot_sec
Q61808
resolver
amino_acid_sequence
MDSWFILVLFGSGLIHVSANNATTVSPSLGTTRLIKTSTTELAKEENKTSNSTSSVISLSVAPTFSPNLTLEPTYVTTVNSSHSDNGTRRAASTESGGTTISPNGSWLIENQFTDAITEPWEGNSSTAATTPETFPPADETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPFLSLAVSKDAVKALNKTTPLLERRFIGKSNSRGCLSDDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNVRVSVEDVTVLVDYTVRKFCIQQVGDVTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHSERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMINIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (PubMed:22801373). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (PubMed:22801373). {ECO:0000269|PubMed:22801373}.
uniprot
proteins
mass_dalton
93698
uniprot
proteins
post_translational_modification
PTM: Integrin binding to extracellular matrix induces phosphorylation at Tyr-825 which induces PTPRA localization and recruitment of BCAR3, BCAR1 and CRK to focal adhesions. {ECO:0000269|PubMed:22801373}.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 4 subfamily
uniprot
proteins
pubmed
1454056
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
1590786
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
1932742
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2162042
uniprot
proteins
pubmed
2166945
uniprot
proteins
pubmed
22801373
uniprot
proteins
pubmed
7832766
uniprot
proteins
pubmed
8406469
uniprot
proteins
pubmed
8700232
uniprot
proteins
sequence_length
829
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22801373}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000269|PubMed:22801373}. Note=Localizes to focal adhesion sites following integrin engagement. {ECO:0000269|PubMed:22801373}.
uniprot
proteins
transmembrane_region
TRANSMEM 143..166; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins