F10
entrez
14058
canonical
uniprot
O88947
canonical
ensembl
ENSMUSG00000031444
resolver
ensp
ENSMUSP00000033821
resolver
ensp
ENSMUSP00000068389
resolver
enst
ENSMUST00000033821
resolver
enst
ENSMUST00000063820
resolver
genesymbol
F10
resolver
uniprot
F8WGE2
resolver
uniprot
O54740
resolver
uniprot
Q3TBR2
resolver
uniprot
Q3U3V1
resolver
uniprot
Q80Y26
resolver
uniprot
Q99L32
resolver
uniprot_entry
F8WGE2_MOUSE
resolver
uniprot_entry
FA10_MOUSE
resolver
uniprot_entry
Q3TBR2_MOUSE
resolver
uniprot_entry
Q3U3V1_MOUSE
resolver
uniprot_entry
Q80Y26_MOUSE
resolver
uniprot_sec
O54740
resolver
uniprot_sec
Q99L32
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by SERPINA5 and SERPINA10. {ECO:0000250|UniProtKB:P00742}.
uniprot
proteins
amino_acid_sequence
MGSPVQLSLLCVVLASLLLPGKGVFINRERANNVLARTRRANSFFEEFKKGNLERECMEEICSYEEVREIFEDDEKTKEYWTKYKDGDQCESSPCQNQGACRDGIGGYTCTCSEGFEGKNCELFVRKLCRLDNGDCDQFCREEQNSVVCSCASGYFLGNDGKSCISTAPFPCGKITTGRRKRSVALNTSDSELDLEDALLDEDFLSPTENPIELLNLNETQPERSSDDLVRIVGGRECKDGECPWQALLINEDNEGFCGGTILNEFYILTAAHCLHQARRFKVRVGDRNTEKEEGNEMVHEVDVVIKHNKFQRDTYDYDIAVLRLKTPITFRMNVAPACLPQKDWAESTLMTQKTGIVSGFGRTHEKGRQSNILKMLEVPYVDRNTCKLSTSFSITQNMFCAGYEAKLEDACQGDSGGPHVTRFKNTYYVTGIVSWGEGCARKGKYGIYTKVTTFLKWIDRSMKARVGPTAETPRTAGPPN
uniprot
proteins
ec_number
3.4.21.6
uniprot
proteins
function
FUNCTION: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (By similarity). Factor Xa activates pro-inflammatory and pro-fibrotic signaling pathways in a protease-activated receptor (PAR)-dependent manner (By similarity). {ECO:0000250|UniProtKB:P00742}.
uniprot
proteins
mass_dalton
54018
uniprot
proteins
post_translational_modification
PTM: Carboxylated by vitamin K-dependent GGCX to form gamma-carboxyglutamate; these residues are essential for the binding of calcium. {ECO:0000250|UniProtKB:P00742}.; PTM: N- and O-glycosylated. {ECO:0000250|UniProtKB:P00742}.; PTM: Proteolytically cleaved and activated by cathepsin CTSG (By similarity). The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway) (By similarity). {ECO:0000250|UniProtKB:P00742, ECO:0000250|UniProtKB:P00743}.; PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. {ECO:0000250|UniProtKB:P00742}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10823271
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16944957
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22383955
uniprot
proteins
pubmed
37469515
uniprot
proteins
pubmed
9684791
uniprot
proteins
pubmed
9783672
uniprot
proteins
sequence_length
481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins