RBM33
entrez
155435
canonical
uniprot
Q96EV2
canonical
ensembl
ENSG00000184863
resolver
ensp
ENSP00000384160
resolver
genesymbol
RBM33
resolver
genesymbol_syn
PRR8
resolver
hgnc
HGNC:27223
resolver
uniprot
A4D244
resolver
uniprot
B5MC24
resolver
uniprot
Q52LF5
resolver
uniprot
Q75LN9
resolver
uniprot
Q75ML5
resolver
uniprot
Q9NSV0
resolver
uniprot_entry
RBM33_HUMAN
resolver
uniprot_sec
A4D244
resolver
uniprot_sec
B5MC24
resolver
uniprot_sec
Q52LF5
resolver
uniprot_sec
Q75LN9
resolver
uniprot_sec
Q75ML5
resolver
uniprot_sec
Q9NSV0
resolver
amino_acid_sequence
MAAALGASGGAGAGDDDFDQFDKPGAERSWRRRAADEDWDSELEDDLLGEDLLSGKKNQSDLSDEELNDDLLQSDNEDEENFSSQGVTISLNATSGMVTSFELSDNTNDQSGEQESEYEQEQGEDELVYHKSDGSELYTQEYPEEGQYEGHEAELTEDQIEYVEEPEEEQLYTDEVLDIEINEPLDEFTGGMETLELQKDIKEESDEEEEDDEESGRLRFKTERKEGTIIRLSDVTRERRNIPETLELSAEAKAALLEFEERERQHKQGRYSSRRGGRRGGPLMCRGVGDQRRESTERGRMKDHRPALLPTQPPVVPQAPPPPPPPPQQQPIRSLFQPQPLQPLLPVQHPHHPSPPQGMHMPPQLETPRMMMTPPPVTPQQPKNIHINPHFKGTVVTPVQVPLLPVPSQPRPAVGPQRFPGPPEFPQHTPGPVPNSFSQPPRLPLQDQWRAPPPPQDRDPFFLGVSGEPRFPSHLFLEQRSPPPPPPPPTLLNSSHPVPTQSPLPFTQPGPAFNQQGQQPVFPRERPVRPALQPPGPVGILHFSQPGSATTRPFIPPRQPFLPGPGQPFLPTHTQPNLQGPLHPPLPPPHQPQPQQPQQQPPPQHQPPHQPPHQPPPQHQPPPQHPPQHPPQHQHHHHHHHLSVPPPPLMPMSQPQFRPHVQTAQPQASSSRMQCPQRQGLRHNTTSQNVSKRPMQQMQPTAPRNSNLRELPIAPSHVIEMSSSRCSATPSAQVKPIVSASPPSRAVAGSRSSQGKTEVKVKPASPVAQPKEEAKTETEFPDEDEETRLYRLKIEEQKRLREEILKQKELRRQQQAGARKKELLERLAQQQQQLYAPPPPAEQEEQALSPSPTNGNPLLPFPGAQVRQNVKNRLLVKNQDVSISNVQPKTSNFVPSSANMQYQGQQMKALKHLRQTRTVPQSQTQPLHKVLPIKPADVEEPAVPQTPRVASIQGRPQDTKPGVKRTVTHRTNSGGGDGPHISSKVRVIKLSGGGGESDGFFHPEGQPQRLPQPPEVGPQPARKVTLTRGGLQQPPHLPAGPHAHSPVPPGIKSIQGIHPAKKAIMHGRGRGVAGPMGRGRLMPNKQNLRVVECKPQPCVVSVEGLSSSTTDAQLKSLLMSVGPIQSLQMLPQQRKAIAKFKEPAHALAFQQKFHRHMIDLSHINVALIVE
uniprot
proteins
function
FUNCTION: RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}.
uniprot
proteins
mass_dalton
129986
uniprot
proteins
mutagenesis
MUTAGEN 1101; /note="S->A: Abolished interaction with ALKBH5."; /evidence="ECO:0000269|PubMed:37257451"; MUTAGEN 1106; /note="S->A: Does not affect interaction with ALKBH5."; /evidence="ECO:0000269|PubMed:37257451"; MUTAGEN 1110; /note="T->A: Does not affect interaction with ALKBH5."; /evidence="ECO:0000269|PubMed:37257451"; MUTAGEN 1134; /note="R->A: Abolished interaction with ALKBH5."; /evidence="ECO:0000269|PubMed:37257451"; MUTAGEN 1169; /note="V->A: Does not affect interaction with ALKBH5."; /evidence="ECO:0000269|PubMed:37257451
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
35589130
uniprot
proteins
pubmed
37257451
uniprot
proteins
sequence_length
1170
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35589130}. Cytoplasm {ECO:0000269|PubMed:35589130}. Note=Localizes predominantly to the nucleus. {ECO:0000269|PubMed:35589130}.
uniprot
proteins