Espn
entrez
56226
canonical
uniprot
Q9ET47
canonical
ensembl
ENSMUSG00000028943
resolver
ensp
ENSMUSP00000030785
resolver
ensp
ENSMUSP00000037982
resolver
ensp
ENSMUSP00000065545
resolver
ensp
ENSMUSP00000078951
resolver
ensp
ENSMUSP00000081131
resolver
ensp
ENSMUSP00000101282
resolver
ensp
ENSMUSP00000101284
resolver
ensp
ENSMUSP00000221564
resolver
ensp
ENSMUSP00000221566
resolver
enst
ENSMUST00000049305
resolver
genesymbol
Espn
resolver
uniprot
A2AK06
resolver
uniprot
A2AK09
resolver
uniprot
A2AK13
resolver
uniprot
B1AWP3
resolver
uniprot
B1AWP6
resolver
uniprot
B1AWQ2
resolver
uniprot
F6S587
resolver
uniprot
Q6GYS0
resolver
uniprot
Q6GYS1
resolver
uniprot
Q80ZC0
resolver
uniprot
Q80ZC1
resolver
uniprot
Q80ZC2
resolver
uniprot
Q80ZC3
resolver
uniprot
Q811J1
resolver
uniprot
Q9DD12
resolver
uniprot
Q9QY27
resolver
uniprot_entry
ESPN_MOUSE
resolver
uniprot_entry
F6S587_MOUSE
resolver
uniprot_entry
Q9DD12_MOUSE
resolver
uniprot_sec
A2AK06
resolver
uniprot_sec
A2AK09
resolver
uniprot_sec
A2AK13
resolver
uniprot_sec
B1AWP3
resolver
uniprot_sec
B1AWP6
resolver
uniprot_sec
B1AWQ2
resolver
uniprot_sec
Q6GYS0
resolver
uniprot_sec
Q6GYS1
resolver
uniprot_sec
Q80ZC0
resolver
uniprot_sec
Q80ZC1
resolver
uniprot_sec
Q80ZC2
resolver
uniprot_sec
Q80ZC3
resolver
uniprot_sec
Q811J1
resolver
uniprot_sec
Q9QY27
resolver
amino_acid_sequence
MALEQALQAARRGDLDVLRSLHAAGLLGPSLRDSLDALPVHHAARSGKLHCLRYLVEEVALPAVSRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVKWLLYQGGANSAITTDTGALPIHYAAAKGDLPSLKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVLSWLLLHGAEISQDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLAEFNGHTHCSRYLRTVQTLSLEHRVLSRDQSMDLEAKQLDSGMSSPNTTMSVQPMTFDLGSPTSTFSNYDSCSSSHSSSKGQRSNRGIPGARAADLQSYMDMLNPEKSLPRGKLGKPSPPPPPPPPPPSFPPPPPPTGTQPPPPPPGYPAPNPPVGLHLNNIYMQTKNKLRHVEVDSLKEPKVELNDQFAQPSSGDGHSGLHRQDSGLLRQDSELLHRQELLRHSTGLRRQDSDRKQRSFSKQPSTGDYYRQLGRSPGEPLAARPGMAHSEEAALLPGNHVHNGCSADSKASRELPPPPPPPPLPEALSSPPPAPPLPIEGAGAACGQRRSSSSTGKVRVLRHRKSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGSGQPASQPESPQPLVSPAPSRTRSPTPPASGSQPLLNGSVVPAPPATPAPGVHLDVEALIPTLDEQGRPIPEWKRQVMVRKLQQKMQEEEEQRRKEEEEEARLASLPAWRRDILRKKLEEEREQKRKEEERQKLEEIQRAKEQSEKLRTLGYDEAKLAPWQRQVILKKGEIPK
uniprot
proteins
function
FUNCTION: Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells (PubMed:14657236, PubMed:15190118). Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia (PubMed:21455486). Involved in the elongation of actin in stereocilia (PubMed:19287378, PubMed:22264607). In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation (PubMed:26926603). {ECO:0000269|PubMed:14657236, ECO:0000269|PubMed:15190118, ECO:0000269|PubMed:19287378, ECO:0000269|PubMed:21455486, ECO:0000269|PubMed:22264607, ECO:0000269|PubMed:26926603}.
uniprot
proteins
mass_dalton
94497
uniprot
proteins
pubmed
10588661
uniprot
proteins
pubmed
10975527
uniprot
proteins
pubmed
12598619
uniprot
proteins
pubmed
14657236
uniprot
proteins
pubmed
15190118
uniprot
proteins
pubmed
16569662
uniprot
proteins
pubmed
19287378
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21455486
uniprot
proteins
pubmed
22264607
uniprot
proteins
pubmed
26754646
uniprot
proteins
pubmed
26785147
uniprot
proteins
pubmed
26926603
uniprot
proteins
sequence_length
871
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, stereocilium {ECO:0000269|PubMed:26754646}. Cell projection, microvillus. Cell junction.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.; SUBCELLULAR LOCATION: [Isoform 8]: Cytoplasm, cytoskeleton. Cell junction. Note=Isoform 8 localizes to parallel actin bundles of ectoplasmic specializations between neighboring Sertoli cells and at sites where Sertoli cells contact the heads of elongate spermatids.
uniprot
proteins