Dnaja3
entrez
83945
canonical
uniprot
Q99M87
canonical
ensembl
ENSMUSG00000004069
resolver
ensp
ENSMUSP00000053842
resolver
ensp
ENSMUSP00000111520
resolver
genesymbol
Dnaja3
resolver
genesymbol_syn
Tid1
resolver
uniprot
Q3TJA9
resolver
uniprot
Q8BSM0
resolver
uniprot
Q99L09
resolver
uniprot
Q99P71
resolver
uniprot
Q99P76
resolver
uniprot
Q9CT11
resolver
uniprot
Q9DBJ7
resolver
uniprot
Q9DC44
resolver
uniprot_entry
DNJA3_MOUSE
resolver
uniprot_entry
Q3TJA9_MOUSE
resolver
uniprot_sec
Q8BSM0
resolver
uniprot_sec
Q99L09
resolver
uniprot_sec
Q99P71
resolver
uniprot_sec
Q99P76
resolver
uniprot_sec
Q9CT11
resolver
uniprot_sec
Q9DBJ7
resolver
uniprot_sec
Q9DC44
resolver
amino_acid_sequence
MAAWCSPRWLRVAVGTPRLPAAAGRGVQQPQGGVVATSLCRKLCVSAFGLSMGAHGPRALLTLRPGVRLTGTKSFPFVCTTSFHTSASLAKDDYYQILGVPRNASQKDIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDPGTSSSGQGYWRGGPSVDPEELFRKIFGEFSSSPFGDFQNVFDQPQEYIMELTFNQAAKGVNKEFTVNIMDTCERCDGKGNEPGTKVQHCHYCGGSGMETINTGPFVMRSTCRRCGGRGSIITNPCVVCRGAGQAKQKKRVTIPVPAGVEDGQTVRMPVGKREIFVTFRVQKSPVFRRDGADIHSDLFISIAQAILGGTAKAQGLYETINVTIPAGIQTDQKIRLTGKGIPRINSYGYGDHYIHIKIRVPKRLSSRQQNLILSYAEDETDVEGTVNGVTHTSTGGRTMDSSAGSKDRREAGEDNEGFLSKLKKIFTS
uniprot
proteins
function
FUNCTION: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity (By similarity). Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:19038220}.
uniprot
proteins
mass_dalton
52443
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated.
uniprot
proteins
pubmed
11116152
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19038220
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:19038220}. Postsynaptic cell membrane {ECO:0000269|PubMed:19038220}; Peripheral membrane protein {ECO:0000269|PubMed:19038220}. Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK.
uniprot
proteins