Pfkp
entrez
60416
canonical
uniprot
P47860
canonical
ensembl
ENSRNOG00000017163
resolver
ensembl
ENSRNOG00055006544
resolver
ensembl
ENSRNOG00060015533
resolver
ensembl
ENSRNOG00065003704
resolver
ensp
ENSRNOP00000023252
resolver
ensp
ENSRNOP00000097741
resolver
ensp
ENSRNOP00000108876
resolver
ensp
ENSRNOP00055008257
resolver
ensp
ENSRNOP00060021340
resolver
ensp
ENSRNOP00065003925
resolver
enst
ENSRNOT00000023252
resolver
enst
ENSRNOT00000108657
resolver
enst
ENSRNOT00000170052
resolver
enst
ENSRNOT00055010648
resolver
enst
ENSRNOT00060026666
resolver
enst
ENSRNOT00065005398
resolver
genesymbol
Pfkp
resolver
genesymbol_syn
Pfk-C
resolver
genesymbol_syn
Pfkc
resolver
uniprot
A0A8I6B663
resolver
uniprot
A0ABK0LXG1
resolver
uniprot
C7C5T2
resolver
uniprot
Q5HZX8
resolver
uniprot_entry
A0A8I6B663_RAT
resolver
uniprot_entry
A0ABK0LXG1_RAT
resolver
uniprot_entry
C7C5T2_RAT
resolver
uniprot_entry
PFKAP_RAT
resolver
uniprot_sec
Q5HZX8
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate. {ECO:0000255|HAMAP-Rule:MF_03184}.
uniprot
proteins
amino_acid_sequence
MSDQDSSTSSTSFPKYLEHLSGDGKAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGMVDGGSNIVEAKWECVSSILQVGGTIIGSARCQAFRSREGRLKAACNLVRLGITNLCVIGGDGSLTGANLFRKEWSGLLEELAKNGEIDSDTVKKHAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEEMCLKLSENRARKKRLNIIIVSEGAIDTQNKPITSEKIKELVVTNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVLALLEATPETPACVVSLRGNQAVRLPLMECVQMTQDVQKAMDERRFDEAVKLRGRSFEGNLNTYKRLAIKEPDDKIPKSNCNVAIINVGAPAAGMNAAVRSAVRVGIAEGHKMFAIYDGFDGLANGQIKEIGWGDVGGWTGQGGSILGTKRTLPGKYLEKIAEQMHSKNINALLIIGGFEAYLGLLELAAARNKHEAFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEQFDIRDLQSNVMHLTEKMKTSIQRGLVLRNENCSVNYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGSHGTGKKFVSDDSICVLGIQKRDLLFKPVAELRKATDFEHRIPKQQWWLKLRPIMKILAKYEASYDMSDVGKLEPVHNHGELSAI
uniprot
proteins
ec_number
2.7.1.11
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. {ECO:0000255|HAMAP-Rule:MF_03184}.
uniprot
proteins
mass_dalton
85720
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. {ECO:0000255|HAMAP-Rule:MF_03184}.
uniprot
proteins
post_translational_modification
PTM: GlcNAcylation decreases enzyme activity. {ECO:0000250}.; PTM: Phosphorylation at Ser-386 promotes interaction with ATG4B. {ECO:0000250|UniProtKB:Q01813}.
uniprot
proteins
protein_family
ATP-dependent PFK group I subfamily
uniprot
proteins
protein_family
Eukaryotic two domain clade 'E' sub-subfamily
uniprot
proteins
protein_family
Phosphofructokinase type A (PFKA) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8106374
uniprot
proteins
sequence_length
788
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}.
uniprot
proteins