Tfap2c
entrez
21420
canonical
uniprot
Q61312
canonical
ensembl
ENSMUSG00000028640
resolver
ensp
ENSMUSP00000030391
resolver
ensp
ENSMUSP00000129922
resolver
enst
ENSMUST00000030391
resolver
enst
ENSMUST00000170744
resolver
genesymbol
Tfap2c
resolver
genesymbol_syn
Tcfap2c
resolver
uniprot
A0A023UF19
resolver
uniprot
F7ASS5
resolver
uniprot
Q3ULB3
resolver
uniprot
Q99L72
resolver
uniprot_entry
A0A023UF19_MOUSE
resolver
uniprot_entry
AP2C_MOUSE
resolver
uniprot_entry
F7ASS5_MOUSE
resolver
uniprot_entry
Q3ULB3_MOUSE
resolver
uniprot_sec
Q99L72
resolver
amino_acid_sequence
MLWKITDNVKYEEDCEDRHDSSSNGNPRIPHLSSPGQHLYSPAPPLSHTGVAEYQPPPYFPPPYQQLAYSQSADHYSHLGEAYAAAMNPLHQPAATGSQQQAWPGRQSQEGSSLASHHSRSASLIPHISGLEGGSVSARREVYRRSDLLLPHAHALEAGLAENLGLHEMAHPIEEVQNVDDAHLLLHDQTVIRKGPISMTKNPLGLPCQKDLVGVVMNPSEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAHVTLLTSLVEGEAVHLARDFAYVCEAEFPSKAVADYLTRPHLGGRNEMATRKSMLLAAQQVCKEFTDLLHQDRTPNGNNRPAQVLEPNIQNCLSHFSLITHGFGSQAICAAVSAVQNYIKEALIAIDKSYMNPGDQSPADSSKTMEKMEKHRK
uniprot
proteins
function
FUNCTION: Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:38243114, PubMed:8660922). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:38243114, PubMed:8660922). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (PubMed:38243114). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (PubMed:38243114). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (PubMed:38243114). Binds to both closed and open chromatin with other transcription factors (PubMed:38243114). {ECO:0000269|PubMed:38243114, ECO:0000269|PubMed:8660922}.
uniprot
proteins
mass_dalton
49137
uniprot
proteins
post_translational_modification
PTM: Sumoylated on Lys-10; which inhibits transcriptional activity. {ECO:0000250|UniProtKB:Q92754}.
uniprot
proteins
protein_family
AP-2 family
uniprot
proteins
pubmed
12504852
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
38243114
uniprot
proteins
pubmed
8660922
uniprot
proteins
sequence_length
449
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92754}.
uniprot
proteins