PLK2
entrez
10769
canonical
uniprot
Q9NYY3
canonical
ensembl
ENSG00000145632
resolver
ensp
ENSP00000274289
resolver
ensp
ENSP00000478685
resolver
genesymbol
PLK2
resolver
genesymbol_syn
SNK
resolver
hgnc
HGNC:19699
resolver
uniprot
A0A087WUH9
resolver
uniprot
O60679
resolver
uniprot
Q96CV7
resolver
uniprot
Q9UE61
resolver
uniprot_entry
PLK2_HUMAN
resolver
uniprot_sec
A0A087WUH9
resolver
uniprot_sec
O60679
resolver
uniprot_sec
Q96CV7
resolver
uniprot_sec
Q9UE61
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation of Thr-239. Once activated, activity is stimulated by binding target proteins (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MELLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQPPQSQAQVPPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTLLMSGCSSELKNRMEYALNMLLQRCN
uniprot
proteins
ec_number
2.7.11.21
uniprot
proteins
function
FUNCTION: Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CPAP, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CPAP and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress. {ECO:0000269|PubMed:15242618, ECO:0000269|PubMed:19001868, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:20531387}.
uniprot
proteins
mass_dalton
78237
uniprot
proteins
mutagenesis
MUTAGEN 210; /note="N->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:19001868"; MUTAGEN 503; /note="W->F: Impairs localization to the centrosome and centriole duplication; when associated with A-629 and M-631."; /evidence="ECO:0000269|PubMed:19001868"; MUTAGEN 629; /note="H->A: Impairs localization to the centrosome and centriole duplication; when associated with F-503 and M-631."; /evidence="ECO:0000269|PubMed:19001868"; MUTAGEN 631; /note="K->M: Impairs localization to the centrosome and centriole duplication; when associated with F-503 and A-631."; /evidence="ECO:0000269|PubMed:19001868
uniprot
proteins
post_translational_modification
PTM: Catalytic activity is enhanced by phosphorylation of Thr-239. {ECO:0000250}.
uniprot
proteins
protein_family
CDC5/Polo subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
11696980
uniprot
proteins
pubmed
11716500
uniprot
proteins
pubmed
15242618
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16160013
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18832181
uniprot
proteins
pubmed
19001868
uniprot
proteins
pubmed
20352051
uniprot
proteins
pubmed
20531387
uniprot
proteins
pubmed
20671765
uniprot
proteins
pubmed
21340720
uniprot
proteins
sequence_length
685
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15242618, ECO:0000269|PubMed:19001868}. Cell projection, dendrite {ECO:0000250}. Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.
uniprot
proteins