Sdhaf1
entrez
68332
canonical
uniprot
Q3U276
canonical
ensembl
ENSMUSG00000074211
resolver
ensp
ENSMUSP00000096185
resolver
enst
ENSMUST00000098586
resolver
genesymbol
Sdhaf1
resolver
genesymbol_syn
Lyrm8
resolver
uniprot
B2RVF8
resolver
uniprot_entry
SDHF1_MOUSE
resolver
uniprot_sec
B2RVF8
resolver
amino_acid_sequence
MSRPSRLQRQVLSLYRELLRAGRGTPGAEARVRAEFRQHASLPRTDVLRIEYLYRRGRRQLQLLRSGHATAMGTFVRPRGPAEEPGDATAPGTRLDDGGAPKNSCEDTGARETRSDGR
uniprot
proteins
function
FUNCTION: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit Sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3. Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. {ECO:0000250|UniProtKB:A6NFY7}.
uniprot
proteins
mass_dalton
13142
uniprot
proteins
protein_family
Complex I LYR family
uniprot
proteins
protein_family
SDHAF1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
118
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:A6NFY7}.
uniprot
proteins