DNAJC15
entrez
29103
canonical
uniprot
Q9Y5T4
canonical
ensembl
ENSG00000120675
resolver
ensp
ENSP00000368523
resolver
enst
ENST00000379221
resolver
genesymbol
DNAJC15
resolver
genesymbol_syn
DNAJD1
resolver
hgnc
HGNC:20325
resolver
uniprot
B2R4L0
resolver
uniprot
Q5T219
resolver
uniprot
Q6X963
resolver
uniprot_entry
DJC15_HUMAN
resolver
uniprot_sec
B2R4L0
resolver
uniprot_sec
Q5T219
resolver
uniprot_sec
Q6X963
resolver
amino_acid_sequence
MAARGVIAPVGESLRYAEYLQPSAKRPDADVDQQRLVRSLIAVGLGVAALAFAGRYAFRIWKPLEQVITETAKKISTPSFSSYYKGGFEQKMSRREAGLILGVSPSAGKAKIRTAHRRVMILNHPDKGGSPYVAAKINEAKDLLETTTKH
uniprot
proteins
disease_involvement
DISEASE: Note=Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin. {ECO:0000269|PubMed:11358853}.
uniprot
proteins
function
FUNCTION: Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. {ECO:0000250, ECO:0000269|PubMed:23263864}.
uniprot
proteins
mass_dalton
16383
uniprot
proteins
pubmed
11358853
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23263864
uniprot
proteins
pubmed
23530063
uniprot
proteins
sequence_length
150
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:23263864, ECO:0000269|PubMed:23530063}; Single-pass membrane protein {ECO:0000269|PubMed:23263864, ECO:0000269|PubMed:23530063}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..58; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins