Srrm3
entrez
685890
canonical
uniprot
D3ZQH1
canonical
ensembl
ENSRNOG00000001439
resolver
ensembl
ENSRNOG00055000330
resolver
ensembl
ENSRNOG00060010551
resolver
ensp
ENSRNOP00000001957
resolver
ensp
ENSRNOP00055000441
resolver
ensp
ENSRNOP00060013862
resolver
enst
ENSRNOT00000001957
resolver
enst
ENSRNOT00055000578
resolver
enst
ENSRNOT00060017846
resolver
genesymbol
Srrm3
resolver
uniprot_entry
SRRM3_RAT
resolver
amino_acid_sequence
MSSTVNNGATSMPAPPDAANGFPQPGGSSGSWPRAEEELRAAEPGLVKRAHREILDHERKRRVELKCMELQEMMEEQGYSEEEIRQKVGTFRQMLMEKEGVLTKEDRPGAHIVAETPRRMEGLEPGLEYPPFDEDDGPVDCDCPVACYRGHRGYRTKHWSSSSASPPPKKKKKKKGSHRRSRKKRRLESECSCGSASPLRKKKRSVKKHRRDRSDSGSRRKRRYRSRSLKSKRKEKIKERKRPHTESPGRRSHHHSSVSSHSPSVSSHYSDSGSPNRLSPKHRDDGRKTGSQRSSGSRSLSPSGGSGWGSPQQNGGSRQRSGAHGGRPGSAHSPPDKPSSPRACDKAAAAPTPPARGKDSQSPRSAPSSQGRGGRAAGGTARRRRRRRRRRRSRSSANAPRRRGRRRAKPAPPRGSSRSLSGAHSSSDSGGGAPGPGPEPGSERGHGGHGKRAKERPPRARPASTSPSPGAHGRRGGPEGNSSSRSPGPHPGSWSSSRSPSKSRSRSPDKRTRSPSLSPSPKKPLGRDKDSEGRARHAEAEAARTRRRSRSYSPIRKRRRDSPSFMEPRRITSARKRPIPYYRPSPSSSSSCLSSDYSSRSRSRSPSPGHSHGSYSSRSHGTRSRSCSASRSRSPSYHSRSSSESGGF
uniprot
proteins
function
FUNCTION: RNA splicing factor that regulates inclusion of microexons in mRNA transcripts (PubMed:36759540). Required for motor coordination. In cortical neurons, acts redundantly with SRRM4 and regulates many alternative splicing events, including inclusion of exon 4 into the transcriptional repressor REST transcript, leading to REST inactivation. REST inactivation de-represses potassium-chloride cotransporter 2/SLC12A5 expression, resulting in the switch in GABAergic neurotransmission from immature excitatory to inhibitory (By similarity). Regulates inclusion of a microexon in TBC1D24 in the brain cortex (By similarity). In pancreatic islets, mediates microexon inclusion. Regulates glucose- and amino acid-stimulated insulin secretion, as well as glucagon secretion (PubMed:36759540). Important for islet morphogenesis during pancreas development (By similarity). Regulates microexon inclusion in the developing retina, which is required for outer segment maintenance and vision (By similarity). {ECO:0000250|UniProtKB:A0AB32TVR3, ECO:0000250|UniProtKB:Q80WV7, ECO:0000269|PubMed:36759540}.
uniprot
proteins
mass_dalton
70923
uniprot
proteins
protein_family
CWC21 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
36759540
uniprot
proteins
sequence_length
648
uniprot
proteins