SLA2
entrez
84174
canonical
uniprot
Q9H6Q3
canonical
ensembl
ENSG00000101082
resolver
ensp
ENSP00000262866
resolver
ensp
ENSP00000353890
resolver
genesymbol
SLA2
resolver
genesymbol_syn
C20orf156
resolver
genesymbol_syn
SLAP2
resolver
hgnc
HGNC:17329
resolver
uniprot
A8K648
resolver
uniprot
E1P5U1
resolver
uniprot
E1P5U2
resolver
uniprot
Q5TH27
resolver
uniprot
Q5TH28
resolver
uniprot
Q8WY18
resolver
uniprot
Q96QI4
resolver
uniprot
Q9H135
resolver
uniprot_entry
SLAP2_HUMAN
resolver
uniprot_sec
A8K648
resolver
uniprot_sec
E1P5U1
resolver
uniprot_sec
E1P5U2
resolver
uniprot_sec
Q5TH27
resolver
uniprot_sec
Q5TH28
resolver
uniprot_sec
Q8WY18
resolver
uniprot_sec
Q96QI4
resolver
uniprot_sec
Q9H135
resolver
amino_acid_sequence
MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEAATGEESLLSEGLRESLSFYISLNDEAVSLDDA
uniprot
proteins
function
FUNCTION: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269|PubMed:11696592}.
uniprot
proteins
mass_dalton
28585
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Abolishes localization to membranes."; /evidence="ECO:0000269|PubMed:11696592
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CSF1R. {ECO:0000250}.
uniprot
proteins
pubmed
11696592
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
11891219
uniprot
proteins
pubmed
12527895
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane. Cytoplasmic vesicle. Note=Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}. Note=May be cytoplasmic and is not localized to membranes.
uniprot
proteins