Adi1
entrez
298934
canonical
uniprot
Q562C9
canonical
ensembl
ENSRNOG00055005737
resolver
ensembl
ENSRNOG00060009020
resolver
ensembl
ENSRNOG00065010582
resolver
ensp
ENSRNOP00055007102
resolver
ensp
ENSRNOP00060011741
resolver
ensp
ENSRNOP00065013106
resolver
enst
ENSRNOT00055009261
resolver
enst
ENSRNOT00060015116
resolver
enst
ENSRNOT00065017124
resolver
genesymbol
Adi1
resolver
genesymbol_syn
Alp1
resolver
genesymbol_syn
Mtcbp1
resolver
uniprot
Q6V9S4
resolver
uniprot_entry
MTND_RAT
resolver
uniprot_sec
Q6V9S4
resolver
amino_acid_sequence
MVQAWYMDESTADPRMPHRAQPDRPVGLEQLRTLGVLYWKLDADKYENDPELEQIRKTRNYSWMDIITICKDSLPNYEEKIKMFFEEHLHLDEEIRYILEGSGYFDVRDKEDKWIRISMEKGDMITLPAGIYHRFTLDEKNYVKAMRLFVGEPVWTPYNRPADHFDARVQYVKFLEGTA
uniprot
proteins
ec_number
1.13.11.53
uniprot
proteins
ec_number
1.13.11.54
uniprot
proteins
function
FUNCTION: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14. {ECO:0000255|HAMAP-Rule:MF_03154}.
uniprot
proteins
mass_dalton
21461
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. {ECO:0000255|HAMAP-Rule:MF_03154}.
uniprot
proteins
protein_family
Acireductone dioxygenase (ARD) family
uniprot
proteins
pubmed
14684610
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
179
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03154}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03154, ECO:0000269|PubMed:14684610}. Cell membrane {ECO:0000255|HAMAP-Rule:MF_03154, ECO:0000269|PubMed:14684610}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03154, ECO:0000269|PubMed:14684610}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03154, ECO:0000269|PubMed:14684610}. Note=Localizes to the plasma membrane when complexed to MMP14. {ECO:0000255|HAMAP-Rule:MF_03154}.
uniprot
proteins