Atp6v0c
entrez
11984
canonical
uniprot
P63082
canonical
ensembl
ENSMUSG00000024121
resolver
ensp
ENSMUSP00000024932
resolver
ensp
ENSMUSP00000111059
resolver
enst
ENSMUST00000024932
resolver
enst
ENSMUST00000098862
resolver
genesymbol
Atp6v0c
resolver
genesymbol_syn
Atp6c
resolver
genesymbol_syn
Atp6l
resolver
genesymbol_syn
Atpl
resolver
genesymbol_syn
Mvp
resolver
uniprot
A3KML5
resolver
uniprot
P23967
resolver
uniprot
Q3TD69
resolver
uniprot
Q4KL27
resolver
uniprot
Q5XK06
resolver
uniprot_entry
A3KML5_MOUSE
resolver
uniprot_entry
VATL_MOUSE
resolver
uniprot_sec
P23967
resolver
uniprot_sec
Q3TD69
resolver
uniprot_sec
Q4KL27
resolver
uniprot_sec
Q5XK06
resolver
amino_acid_sequence
MADIKNNPEYSSFFGVMGASSAMVFSAMGAAYGTAKSGTGIAAMSVMRPELIMKSIIPVVMAGIIAIYGLVVAVLIANSLTDGITLYRSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK
uniprot
proteins
function
FUNCTION: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments, and in some cell types, it is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). {ECO:0000250|UniProtKB:P23956, ECO:0000250|UniProtKB:P27449}.
uniprot
proteins
mass_dalton
15808
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by RNF182, leading to its degradation via the ubiquitin-proteasome pathway. {ECO:0000250|UniProtKB:P27449}.
uniprot
proteins
protein_family
V-ATPase proteolipid subunit family
uniprot
proteins
pubmed
11441017
uniprot
proteins
pubmed
11495928
uniprot
proteins
pubmed
11595166
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1828149
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8741845
uniprot
proteins
sequence_length
155
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P63081}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P63081}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:P27449}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 56..76; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 132..152; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins