Agap1
entrez
347722
canonical
uniprot
Q8BXK8
canonical
ensembl
ENSMUSG00000055013
resolver
ensp
ENSMUSP00000027521
resolver
ensp
ENSMUSP00000074478
resolver
ensp
ENSMUSP00000140599
resolver
enst
ENSMUST00000027521
resolver
enst
ENSMUST00000074945
resolver
enst
ENSMUST00000190096
resolver
genesymbol
Agap1
resolver
genesymbol_syn
Centg2
resolver
genesymbol_syn
Kiaa1099
resolver
uniprot
A0A087WRF2
resolver
uniprot
E9Q3K3
resolver
uniprot
Q3UHA0
resolver
uniprot
Q6ZPX9
resolver
uniprot
Q8BZG0
resolver
uniprot_entry
A0A087WRF2_MOUSE
resolver
uniprot_entry
AGAP1_MOUSE
resolver
uniprot_entry
E9Q3K3_MOUSE
resolver
uniprot_sec
Q3UHA0
resolver
uniprot_sec
Q6ZPX9
resolver
uniprot_sec
Q8BZG0
resolver
activity_regulation
ACTIVITY REGULATION: GAP activity stimulated by phosphatidylinositol 3,4,5-trisphosphate (PIP3) and, to a lesser extent, by phosphatidylinositol 4,5-bisphosphate (PIP2). Phosphatidic acid potentiates PIP2 stimulation (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAISSTNPRVIDDVRARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPKTNGLAKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQWSDATVIANSAISSDTGLGDSVCSSPSISSSTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENLEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCDTQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPMELIKVMSSIGNELANSVWEEGSQGRTKPSLDSTREEKERWIRAKYEQKLFLAPLPCTEFSLGQQLLRATAEEDLRTVILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLSRKSNSRNNSSGRAPSVI
uniprot
proteins
function
FUNCTION: GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
94411
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines. {ECO:0000250}.
uniprot
proteins
protein_family
Centaurin gamma-like family
uniprot
proteins
pubmed
12640130
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15381706
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
857
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Associates with the endocytic compartment. {ECO:0000250}.
uniprot
proteins