Aloxe3
entrez
287424
canonical
uniprot
D3ZKX9
canonical
ensembl
ENSRNOG00000007454
resolver
ensembl
ENSRNOG00055032634
resolver
ensembl
ENSRNOG00060020365
resolver
ensembl
ENSRNOG00065025961
resolver
ensp
ENSRNOP00000010141
resolver
ensp
ENSRNOP00000102822
resolver
ensp
ENSRNOP00000105835
resolver
ensp
ENSRNOP00055046487
resolver
ensp
ENSRNOP00060028978
resolver
ensp
ENSRNOP00065036630
resolver
enst
ENSRNOT00000010141
resolver
enst
ENSRNOT00000125878
resolver
enst
ENSRNOT00000149702
resolver
enst
ENSRNOT00055056381
resolver
enst
ENSRNOT00060035249
resolver
enst
ENSRNOT00065044734
resolver
genesymbol
Aloxe3
resolver
uniprot
A0ABK0LDR1
resolver
uniprot
A0ABK0LQA1
resolver
uniprot_entry
A0ABK0LDR1_RAT
resolver
uniprot_entry
A0ABK0LQA1_RAT
resolver
uniprot_entry
LOXE3_RAT
resolver
amino_acid_sequence
MAVYRLCVTTGSYLKAGTLDNIYATLVGTCGESPKQKLDRVGRDFATGSVQKYKVRCASELGEILLLRLHKERFAFFCKDPWYCSRICVTTPDGSVVHFPCYQWIDGYCTVELRPGTARTICQDALPLLLDHRKRELQARQECYRWKIYAPGFPRMVDVSSFEEMESDKKFALTKTAPCADQDDNSGNRYLPGFPMKVDIPSLLHMEPNIRYSATKTASLIFNALPASLGMKIRGLLDRKGSWKRLDDIRNIFWCHKTFTSEYVTEHWCEDSFFGYQYLNGVNPIMLHCLSSLPSKLPVTNDMVAPLLGPGTCLQTELERGHIFLADYWILAEAPVHCLNGRQQYVTAPLCLLWLNPQGVLLPLAIQLSQIPGPESPIFLPTDCELDWLLAKTWVRNSEFLVHENNTHFLCTHLLCEAFSMATLRQLPLCHPVYKLLLPHTRYTLQVNTIARATLLNPDGLVDKVTSIGRRGLIYLMSTGLAHFTYTDFCLPDSLRARGVLTIPNYHYRDDGLKIWAAIERFVSEIVSYYYPNDACVQQDSELQAWVGEIFAQAFLGRESSGFPSRLCTPGELVKYLTAIIFNCSAQHAAVNSGQHDFGAWMPNAPSSMRQPPPQTKGNTTMESYLETLPEVNTTCSNLLLFWLVSQEPKDQRPLGTYPDEHFTEEAPRQSIAAFQKCLAQISKDIRARNESLALPYAYLDPPLIENSVSI
uniprot
proteins
ec_number
4.2.1.152
uniprot
proteins
ec_number
5.4.4.7
uniprot
proteins
function
FUNCTION: Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites (By similarity). Also plays a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG (By similarity). Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (PubMed:23382512). {ECO:0000250|UniProtKB:Q9BYJ1, ECO:0000250|UniProtKB:Q9WV07, ECO:0000269|PubMed:23382512}.
uniprot
proteins
mass_dalton
80440
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. {ECO:0000250|UniProtKB:Q9BYJ1}.; PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000250|UniProtKB:Q9BYJ1}.
uniprot
proteins
protein_family
Lipoxygenase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
23382512
uniprot
proteins
sequence_length
711
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00726}.
uniprot
proteins