Cetn2
entrez
26370
canonical
uniprot
Q9R1K9
canonical
ensembl
ENSMUSG00000031347
resolver
ensp
ENSMUSP00000110198
resolver
enst
ENSMUST00000114551
resolver
genesymbol
Cetn2
resolver
genesymbol_syn
Calt
resolver
uniprot
B1AUQ6
resolver
uniprot
B1AUQ8
resolver
uniprot
Q3UBB4
resolver
uniprot
Q9CWM0
resolver
uniprot_entry
CETN2_MOUSE
resolver
uniprot_sec
B1AUQ6
resolver
uniprot_sec
B1AUQ8
resolver
uniprot_sec
Q3UBB4
resolver
uniprot_sec
Q9CWM0
resolver
amino_acid_sequence
MASNFKKTTMASSAQRKRMSPKPELTEDQKQEIREAFDLFDADGTGTIDIKELKVAMRALGFEPKKEEIKKMISEIDKEGTGKMNFSDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVNEQEFLRIMKKTSLY
uniprot
proteins
function
FUNCTION: Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity). {ECO:0000250}.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with Rad23b appears to stabilize Xpc. In vitro, stimulates DNA binding of the Xpc:Rad23b dimer (By similarity). {ECO:0000250}.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (By similarity). {ECO:0000250}.; FUNCTION: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. {ECO:0000250|UniProtKB:P41208}.
uniprot
proteins
mass_dalton
19797
uniprot
proteins
protein_family
Centrin family
uniprot
proteins
pubmed
10854409
uniprot
proteins
pubmed
11250075
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
172
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P41208}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:11250075}. Nucleus {ECO:0000250|UniProtKB:P41208}. Nucleus envelope {ECO:0000250|UniProtKB:P41208}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P41208}. Note=Localizes to the inner scaffold in the central region of centrioles and to the distal end of centrioles. {ECO:0000250|UniProtKB:P41208}.
uniprot
proteins