RPH3A
entrez
22895
canonical
uniprot
Q9Y2J0
canonical
ensembl
ENSG00000089169
resolver
ensp
ENSP00000374036
resolver
ensp
ENSP00000405357
resolver
ensp
ENSP00000440384
resolver
ensp
ENSP00000448297
resolver
genesymbol
RPH3A
resolver
genesymbol_syn
KIAA0985
resolver
hgnc
HGNC:17056
resolver
uniprot
B7Z3C3
resolver
uniprot
Q96AE0
resolver
uniprot_entry
RP3A_HUMAN
resolver
uniprot_sec
B7Z3C3
resolver
uniprot_sec
Q96AE0
resolver
amino_acid_sequence
MTDTVFSNSSNRWMYPSDRPLQSNDKEQLQAGWSVHPGGQPDRQRKQEELTDEEKEIINRVIARAEKMEEMEQERIGRLVDRLENMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKKNVCTKCGVETNNRLHSVWLCKICIEQREVWKRSGAWFFKGFPKQVLPQPMPIKKTKPQQPVSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKTGPDPASAPGRGNYGPPVRRASEARMSSSSRDSESWDHSGGAGDSSRSPAGLRRANSVQASRPAPGSVQSPAPPQPGQPGTPGGSRPGPGPAGRFPDQKPEVAPSDPGTTAPPREERTGGVGGYPAVGAREDRMSHPSGPYSQASAAAPQPAAARQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNENHVSSD
uniprot
proteins
function
FUNCTION: Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity). {ECO:0000250|UniProtKB:P47709}.
uniprot
proteins
mass_dalton
76872
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Deubiquitinated by CAND1 to prevent its degradation. {ECO:0000250|UniProtKB:P47709}.
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15207266
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
40166812
uniprot
proteins
pubmed
41492970
uniprot
proteins
sequence_length
694
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P47709}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P47709}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P47709}. Membrane {ECO:0000250|UniProtKB:P47709}; Peripheral membrane protein {ECO:0000250|UniProtKB:P47709}.
uniprot
proteins