Htr2b
entrez
15559
canonical
uniprot
Q02152
canonical
ensembl
ENSMUSG00000026228
resolver
ensp
ENSMUSP00000027431
resolver
enst
ENSMUST00000027431
resolver
genesymbol
Htr2b
resolver
uniprot
Q8JZK5
resolver
uniprot
Q9QWS2
resolver
uniprot_entry
5HT2B_MOUSE
resolver
uniprot_sec
Q8JZK5
resolver
uniprot_sec
Q9QWS2
resolver
amino_acid_sequence
MASSYKMSEQSTTSEHILQKTCDHLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLILAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWLISIGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFLTIHTLQKKAYLVKNKPPQRLTRWTVPTVFLREDSSFSSPEKVAMLDGSHRDKILPNSSDETLMRRMSSVGKRSAQTISNEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCNQTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKSVKALRKFSSTLCFGNSMVENSKFFTKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLTENDGDKAEEQVSYI
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1426253, PubMed:17325130). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:1426253, PubMed:16940156). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). HTR2B is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (By similarity). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity (PubMed:16940156, PubMed:18337424). May play a role in the perception of pain (PubMed:21273425). Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development (PubMed:10944220, PubMed:11413089). Protects cardiomyocytes against apoptosis (PubMed:12738797). Plays a role in the adaptation of pulmonary arteries to chronic hypoxia (PubMed:12244304). Plays a role in vasoconstriction (PubMed:12244304, PubMed:23346101). Required for normal osteoblast function and proliferation, and for maintaining normal bone density (PubMed:17846081). Required for normal proliferation of the interstitial cells of Cajal in the intestine (PubMed:19941613). {ECO:0000250|UniProtKB:P41595, ECO:0000269|PubMed:10944220, ECO:0000269|PubMed:11413089, ECO:0000269|PubMed:12244304, ECO:0000269|PubMed:12738797, ECO:0000269|PubMed:1426253, ECO:0000269|PubMed:16940156, ECO:0000269|PubMed:17325130, ECO:0000269|PubMed:17846081, ECO:0000269|PubMed:18337424, ECO:0000269|PubMed:19941613, ECO:0000269|PubMed:21179162, ECO:0000269|PubMed:21273425, ECO:0000269|PubMed:23346101}.
uniprot
proteins
mass_dalton
53597
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10944220
uniprot
proteins
pubmed
11413089
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
12244304
uniprot
proteins
pubmed
12738797
uniprot
proteins
pubmed
1426253
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16940156
uniprot
proteins
pubmed
17325130
uniprot
proteins
pubmed
17846081
uniprot
proteins
pubmed
18337424
uniprot
proteins
pubmed
19941613
uniprot
proteins
pubmed
21179162
uniprot
proteins
pubmed
21273425
uniprot
proteins
pubmed
23346101
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1426253, ECO:0000269|PubMed:17325130}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41595}. Synapse, synaptosome {ECO:0000269|PubMed:18337424}.
uniprot
proteins
transmembrane_region
TRANSMEM 56..78; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P41595"; TRANSMEM 90..112; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P41595"; TRANSMEM 129..150; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P41595"; TRANSMEM 171..191; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P41595"; TRANSMEM 216..238; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P41595"; TRANSMEM 324..344; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P41595"; TRANSMEM 360..381; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P41595
uniprot
proteins