P27732
uniprot
P27732
canonical
amino_acid_sequence
MMMMMMMKKMQHQRQQQEDHANEANYARGTRLPISGEGPTSQPNSSKQTVLSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVDWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIASGLLLHPNASVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCAANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGETQGCCGSLWCWWKRRGAAKTGPSGCRRWGQAISKSKLRSHGAREALCVCRCSLESLVKLWTSRFSAHLQAAYVRPYSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLKLFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEEAEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEDSKPEEEDVFKRNGALLGNYVNHVNSDRRESLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGDLEHVSENGHYSYKHDRELQRRSSIKRTRYYETYIRSESGDEQLPTIFREDPEIHGYFRDPRCFGEQEYFSSEECCEDDSSPTWSRQNYSYYNRYPGSSMDFERPRGYHHPQGFLEDDDSPIGYDSRRSPRRRLLPPTPPSHRRSSFNFECLRRQNSQDDVLPSPALPHRAALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVDRSESMDQVNGSLPSLHRSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGSVCPRANGDMGPISHRQDYELQDFGPGYSDEEPDPGREEEDLADEMICITTL
uniprot
proteins
function
FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. {ECO:0000269|PubMed:17050707, ECO:0000269|PubMed:7760845}.; FUNCTION: [Isoform 1]: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. {ECO:0000269|PubMed:7760845}.; FUNCTION: [Isoform 2]: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. {ECO:0000269|PubMed:7760845}.
uniprot
proteins
mass_dalton
250136
uniprot
proteins
mutagenesis
MUTAGEN 1656..1657; /note="IQ->AA: Loss of calcium-dependent inactivation related to the C-terminal lobe of calmodulin."; /evidence="ECO:0000269|PubMed:17050707
uniprot
proteins
protein_family
CACNA1D subfamily
uniprot
proteins
protein_family
Calcium channel alpha-1 subunit (TC 1.A.1.11) family
uniprot
proteins
pubmed
1279681
uniprot
proteins
pubmed
1648940
uniprot
proteins
pubmed
1692134
uniprot
proteins
pubmed
17050707
uniprot
proteins
pubmed
7479909
uniprot
proteins
pubmed
7553731
uniprot
proteins
pubmed
7760845
uniprot
proteins
pubmed
9232351
uniprot
proteins
sequence_length
2203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q01668}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 127..145; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 164..183; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 196..214; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 236..254; /note="Helical; Name=S4 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 274..293; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 382..406; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 583..602; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 618..636; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 645..663; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 674..692; /note="Helical; Name=S4 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 712..732; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 787..811; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 946..964; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 981..1000; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1013..1031; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1038..1057; /note="Helical; Name=S4 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1077..1096; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1187..1207; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1265..1283; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1299..1318; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1326..1347; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1358..1377; /note="Helical; Name=S4 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1397..1416; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1484..1508; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000255
uniprot
proteins