PTGS1
entrez
5742
canonical
uniprot
P23219
canonical
ensembl
ENSG00000095303
resolver
ensp
ENSP00000223423
resolver
ensp
ENSP00000354612
resolver
ensp
ENSP00000362802
resolver
ensp
ENSP00000437709
resolver
ensp
ENSP00000483540
resolver
ensp
ENSP00000494717
resolver
ensp
ENSP00000533448
resolver
enst
ENST00000619306
resolver
genesymbol
PTGS1
resolver
genesymbol_syn
COX1
resolver
hgnc
HGNC:9604
resolver
uniprot
A0A087X296
resolver
uniprot
A8K1V7
resolver
uniprot
B4DHQ2
resolver
uniprot
B4E2S5
resolver
uniprot
Q15122
resolver
uniprot
Q3HY28
resolver
uniprot
Q3HY29
resolver
uniprot
Q5T7T6
resolver
uniprot
Q5T7T7
resolver
uniprot
Q5T7T8
resolver
uniprot_entry
A0A087X296_HUMAN
resolver
uniprot_entry
PGH1_HUMAN
resolver
uniprot_sec
A8K1V7
resolver
uniprot_sec
B4DHQ2
resolver
uniprot_sec
B4E2S5
resolver
uniprot_sec
Q15122
resolver
uniprot_sec
Q3HY28
resolver
uniprot_sec
Q3HY29
resolver
uniprot_sec
Q5T7T6
resolver
uniprot_sec
Q5T7T7
resolver
uniprot_sec
Q5T7T8
resolver
activity_regulation
ACTIVITY REGULATION: The cyclooxygenase activity is inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen, flurbiprofen, ketoprofen, naproxen, flurbiprofen, anirolac, fenclofenac and diclofenac. {ECO:0000269|PubMed:7947975}.
uniprot
proteins
amino_acid_sequence
MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
uniprot
proteins
ec_number
1.14.99.1
uniprot
proteins
function
FUNCTION: Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons (PubMed:7947975). Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (Probable). Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products (By similarity). {ECO:0000250|UniProtKB:P05979, ECO:0000269|PubMed:7947975, ECO:0000305|PubMed:10966456, ECO:0000305|PubMed:24605250}.
uniprot
proteins
mass_dalton
68686
uniprot
proteins
mutagenesis
MUTAGEN 529; /note="S->N: Abolishes cyclooxygenase activity."; /evidence="ECO:0000269|PubMed:1907252
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; prostaglandin biosynthesis. {ECO:0000269|PubMed:7947975}.
uniprot
proteins
protein_family
Prostaglandin G/H synthase family
uniprot
proteins
pubmed
10966456
uniprot
proteins
pubmed
12192304
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15308583
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1587858
uniprot
proteins
pubmed
16141368
uniprot
proteins
pubmed
1734857
uniprot
proteins
pubmed
1907252
uniprot
proteins
pubmed
24605250
uniprot
proteins
pubmed
2512924
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7947975
uniprot
proteins
sequence_length
599
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
uniprot
proteins