Abcc1
entrez
17250
canonical
uniprot
O35379
canonical
ensembl
ENSMUSG00000023088
resolver
ensp
ENSMUSP00000097743
resolver
ensp
ENSMUSP00000169322
resolver
ensp
ENSMUSP00000169328
resolver
enst
ENSMUST00000100167
resolver
genesymbol
Abcc1
resolver
genesymbol_syn
Abcc1a
resolver
genesymbol_syn
Abcc1b
resolver
genesymbol_syn
Mdrap
resolver
genesymbol_syn
Mrp
resolver
uniprot
A5D6P3
resolver
uniprot_entry
A5D6P3_MOUSE
resolver
uniprot_entry
MRP1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: MK 571 inhibits sphingosine 1-phosphate and leukotriene C4 export. {ECO:0000250|UniProtKB:P33527}.
uniprot
proteins
amino_acid_sequence
MALRSFCSADGSDPLWDWNVTWHTSNPDFTKCFQNTVLTWVPCFYLWSCFPLYFFYLSRHDRGYIQMTHLNKTKTALGFFLWIICWADLFYSFWERSQGVLRAPVLLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALLCALAILRSKIISALKKDAHVDVFRDSTFYLYFTLVLVQLVLSCFSDCSPLFSETVHDRNPCPESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPVRIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPKILELIINFVNDREAPDWQGYFYTALLFVSACLQTLALHQYFHICFVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRSIKSGEGNSITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTYANAEQDLASEDDSVSGSGKESKPVENGMLVTDTVGKHLQRHLSNSSSHSGDTSQQHSSIAELQKAGAKEETWKLMEADKAQTGQVQLSVYWNYMKAIGLFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQANRNFRLSVYGALGILQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELLQQRGIFYSMAKDAGLV
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
ec_number
7.6.2.3
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable the active transport of organic anions conjugated with glutathione, glucuronate or sulfate. Operates at the plasma membrane where it mediates the efflux of substrates from the cytoplasm into the extracellular space. The rate of transport is in some way coupled to the reduced glutathione (GSH) intracellular levels (By similarity). Mediates the systemic release of glutathione-conjugated leukotriene C4 (LTC4) from myeloid cells such as mast cells, as part of the inflammatory response (PubMed:9281595, PubMed:9359705). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (PubMed:34088745). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells. Can export both GSH and its oxidized form GSSG in a protective mechanism that limits cellular damage especially during oxidative stress. Regulates GSH and GSSG release from astrocytes to maintain glutathione redox equilibrium in the brain (PubMed:16539673). Transports signaling molecules. Appears to selectively recognize cyclic 2'3'-GMP-AMP (cGAMP) produced by mammals but not 3'3'-cGAMP produced by bacteria. Mediates 2'3'-cGAMP export and limits intracellular cGAMP-mediated cGAS-STING signaling and type I interferon synthesis (PubMed:36070769). Exports sphingosine 1-phosphate from mast cells independently of their degranulation. Confers resistance to anticancer drugs by mediating ATP- and GSH-dependent drug export. Similarly to MRP2, transports various steroids, bile acids and bilirubin conjugates (By similarity). {ECO:0000250|UniProtKB:P33527, ECO:0000269|PubMed:16539673, ECO:0000269|PubMed:34088745, ECO:0000269|PubMed:36070769, ECO:0000269|PubMed:9281595, ECO:0000269|PubMed:9359705}.
uniprot
proteins
mass_dalton
171185
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCC family
uniprot
proteins
protein_family
Conjugate transporter (TC 3.A.1.208) subfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16539673
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
34088745
uniprot
proteins
pubmed
36070769
uniprot
proteins
pubmed
8649356
uniprot
proteins
pubmed
9281595
uniprot
proteins
pubmed
9359705
uniprot
proteins
sequence_length
1528
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P33527}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P33527}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..50; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 76..90; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 107..120; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 137..150; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 173..188; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 330..343; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 368..382; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 444..457; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 470..485; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 546..561; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 587..600; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 969..985; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 1020..1035; /note="Helical; Name=13"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 1089..1105; /note="Helical; Name=14"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 1111..1123; /note="Helical; Name=15"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 1198..1211; /note="Helical; Name=16"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 1230..1243; /note="Helical; Name=17"; /evidence="ECO:0000250|UniProtKB:P33527
uniprot
proteins