P0C0A2
uniprot
P0C0A2
canonical
amino_acid_sequence
MDRFVWTSGLLEINETLVIQQRGVRVYDGEEKIKFDAGTLLLSTHRLIWRDQKNNECCMAIPLSQIVFIEEQAAGIGKSAKIVVHLHPAPPNKEPGPFQSSKNSYIKLSFKEHGQIEFYRRLSEEMTQRRWETVPVSQSLQTKKGPQPGRIRAVGIVGIERKLEEKRKETDKNISEAFEDLSKLMIQAKEMVELSKSIANKIKEKQGDVTEDETIRFKSYLLSMGIANPVTRETYGSGTQYHMQLAKQLAGILQAPLEERGGIMSLTEVYCLVNRARGMELLSPEDLVNACKMLEGLKLPVRLRVFDSGVMVIELQTHKEEEMVASALETVSERGSLTSEEFAKLVGMSVLLAKERLLLAEKMGHLCRDDSVEGLRFYPNLFMTQN
uniprot
proteins
function
FUNCTION: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3 (By similarity). {ECO:0000250|UniProtKB:Q86VN1, ECO:0000250|UniProtKB:Q91XD6}.
uniprot
proteins
mass_dalton
43718
uniprot
proteins
protein_family
VPS36 family
uniprot
proteins
pubmed
11278625
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Endosome {ECO:0000250}. Late endosome {ECO:0000250|UniProtKB:Q91XD6}. Membrane {ECO:0000250}. Nucleus {ECO:0000305}. Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation. {ECO:0000250|UniProtKB:Q91XD6}.
uniprot
proteins