Actg1
entrez
11465
canonical
uniprot
P63260
canonical
ensembl
ENSMUSG00000062825
resolver
ensp
ENSMUSP00000071486
resolver
ensp
ENSMUSP00000101822
resolver
enst
ENSMUST00000071555
resolver
enst
ENSMUST00000106215
resolver
genesymbol
Actg1
resolver
genesymbol_syn
Actg
resolver
uniprot
P02571
resolver
uniprot
P14104
resolver
uniprot
P99022
resolver
uniprot
Q4KL81
resolver
uniprot_entry
ACTG_MOUSE
resolver
uniprot_entry
Q4KL81_MOUSE
resolver
uniprot_sec
P02571
resolver
uniprot_sec
P14104
resolver
uniprot_sec
P99022
resolver
amino_acid_sequence
MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Plays a role in the repair of noise-induced stereocilia gaps following recruitment by XIRP2 isoform 3, thereby maintains hearing sensitivity following loud noise damage (PubMed:37294664). {ECO:0000250|UniProtKB:P63261, ECO:0000269|PubMed:37294664}.
uniprot
proteins
mass_dalton
41793
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="G->R: No effect on interaction with XIRP2."; /evidence="ECO:0000269|PubMed:37294664
uniprot
proteins
post_translational_modification
PTM: Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form (PubMed:23911929). The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (PubMed:23911929). {ECO:0000269|PubMed:23911929}.; PTM: Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. {ECO:0000250|UniProtKB:P63261}.; PTM: [Actin, cytoplasmic 2, N-terminally processed]: N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. In contrast, filament nucleation by the Arp2/3 complex is not affected. {ECO:0000250|UniProtKB:P63261}.; PTM: [Actin, cytoplasmic 2]: N-terminal cleavage of acetylated methionine of immature cytoplasmic actin by ACTMAP. {ECO:0000250|UniProtKB:P63261}.; PTM: Methylated at His-73 by SETD3. {ECO:0000250|UniProtKB:P63261}.
uniprot
proteins
protein_family
Actin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
213279
uniprot
proteins
pubmed
23911929
uniprot
proteins
pubmed
3210229
uniprot
proteins
pubmed
3221869
uniprot
proteins
pubmed
37294664
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P63261}.
uniprot
proteins