Trem1
entrez
58217
canonical
uniprot
Q9JKE2
canonical
ensembl
ENSMUSG00000042265
resolver
ensp
ENSMUSP00000038636
resolver
ensp
ENSMUSP00000108877
resolver
enst
ENSMUST00000048782
resolver
enst
ENSMUST00000113251
resolver
genesymbol
Trem1
resolver
uniprot
F7A1H8
resolver
uniprot
Q14DT9
resolver
uniprot
Q3TAL7
resolver
uniprot_entry
F7A1H8_MOUSE
resolver
uniprot_entry
Q14DT9_MOUSE
resolver
uniprot_entry
TREM1_MOUSE
resolver
uniprot_sec
Q3TAL7
resolver
amino_acid_sequence
MRKAGLWGLLCVFFVSEVKAAIVLEEERYDLVEGQTLTVKCPFNIMKYANSQKAWQRLPDGKEPLTLVVTQRPFTRPSEVHMGKFTLKHDPSEAMLQVQMTDLQVTDSGLYRCVIYHPPNDPVVLFHPVRLVVTKGSSDVFTPVIIPITRLTERPILITTKYSPSDTTTTRSLPKPTAVVSSPGLGVTIINGTDADSVSTSSVTISVICGLLSKSLVFIILFIVTKRTFG
uniprot
proteins
function
FUNCTION: Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:23241959, PubMed:27328755). By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (By similarity). {ECO:0000250|UniProtKB:Q9NP99, ECO:0000269|PubMed:23241959, ECO:0000269|PubMed:27328755}.
uniprot
proteins
mass_dalton
25409
uniprot
proteins
pubmed
10799849
uniprot
proteins
pubmed
15561137
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23241959
uniprot
proteins
pubmed
27328755
uniprot
proteins
sequence_length
230
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NP99}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9NP99}. Note=Recruited to lipid rafts when activated. {ECO:0000250|UniProtKB:Q9NP99}.
uniprot
proteins
transmembrane_region
TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins