Htra2
entrez
64704
canonical
uniprot
Q9JIY5
canonical
ensembl
ENSMUSG00000068329
resolver
ensp
ENSMUSP00000087073
resolver
enst
ENSMUST00000089645
resolver
genesymbol
Htra2
resolver
genesymbol_syn
Omi
resolver
genesymbol_syn
Prss25
resolver
uniprot
Q9R108
resolver
uniprot_entry
HTRA2_MOUSE
resolver
uniprot_sec
Q9R108
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by BIRC6. {ECO:0000250|UniProtKB:O43464}.
uniprot
proteins
amino_acid_sequence
MAALKAGRGANWSLRAWRALGGIFWRKPPLLAPDLRALLTSGTPDSQIWMTYGTPSLPAQVPEGFLASRADLTSRTPDLWARLNVGTSGSSDQEARRSPGSRRREWLAVAVGAGGAVVLLLWGWGRGLSTVLAAVPAPPPTSPRSQYNFIADVVEKTAPAVVYIEILDRHPFSGREVPISNGSGFVVASDGLIVTNAHVVADRRRVRVRLPSGDTYEAMVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQNNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSWFGTSGSQRRYIGVMMLTLTPSILIELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEKLAQNAEDVYEAVRTQSQLAVRIRRGSETLTLYVTPEVTE
uniprot
proteins
ec_number
3.4.21.108
uniprot
proteins
function
FUNCTION: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (By similarity). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (PubMed:11604410). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (By similarity). Cleaves THAP5 and promotes its degradation during apoptosis (By similarity). {ECO:0000250|UniProtKB:O43464, ECO:0000269|PubMed:11604410}.
uniprot
proteins
mass_dalton
49348
uniprot
proteins
mutagenesis
MUTAGEN 134; /note="A->G: Loss of interaction with XIAP."; /evidence="ECO:0000269|PubMed:11604410"; MUTAGEN 137; /note="A->I: Stronger interaction with XIAP third BIR domain."; /evidence="ECO:0000269|PubMed:11604410"; MUTAGEN 306; /note="S->A: Loss of protease activity."; /evidence="ECO:0000269|PubMed:11604410
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by BIRC6; this activity is inhibited by DIABLO/SMAC. {ECO:0000250|UniProtKB:O43464}.; PTM: Autoproteolytically activated. {ECO:0000250|UniProtKB:O43464}.
uniprot
proteins
protein_family
Peptidase S1C family
uniprot
proteins
pubmed
10971580
uniprot
proteins
pubmed
11604410
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23479728
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space. Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with BID.
uniprot
proteins
transmembrane_region
TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins