Tnfrsf14
entrez
230979
canonical
uniprot
Q80WM9
canonical
ensembl
ENSMUSG00000042333
resolver
ensp
ENSMUSP00000116757
resolver
ensp
ENSMUSP00000151575
resolver
enst
ENSMUST00000123514
resolver
enst
ENSMUST00000219534
resolver
genesymbol
Tnfrsf14
resolver
genesymbol_syn
hvem
resolver
uniprot
A0A1W2P7D5
resolver
uniprot_entry
A0A1W2P7D5_MOUSE
resolver
uniprot_entry
TNR14_MOUSE
resolver
amino_acid_sequence
MEPLPGWGSAPWSQAPTDNTFRLVPCVFLLNLLQRISAQPSCRQEEFLVGDECCPMCNPGYHVKQVCSEHTGTVCAPCPPQTYTAHANGLSKCLPCGVCDPDMGLLTWQECSSWKDTVCRCIPGYFCENQDGSHCSTCLQHTTCPPGQRVEKRGTHDQDTVCADCLTGTFSLGGTQEECLPWTNCSAFQQEVRRGTNSTDTTCSSQVVYYVVSILLPLVIVGAGIAGFLICTRRHLHTSSVAKELEPFQEQQENTIRFPVTEVGFAETEEETASN
uniprot
proteins
function
FUNCTION: Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (By similarity). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (By similarity). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:25711213). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (PubMed:22801499). Upon binding to CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (By similarity). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed:15568026, PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:15568026, PubMed:19915044). {ECO:0000250|UniProtKB:Q92956, ECO:0000269|PubMed:15568026, ECO:0000269|PubMed:19915044, ECO:0000269|PubMed:22801499, ECO:0000269|PubMed:25711213}.
uniprot
proteins
mass_dalton
30171
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000255|PROSITE-ProRule:PRU00498}.
uniprot
proteins
protein_family
Tumor necrosis factor receptor superfamily
uniprot
proteins
pubmed
15568026
uniprot
proteins
pubmed
18193050
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19915044
uniprot
proteins
pubmed
22801499
uniprot
proteins
pubmed
25711213
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15568026}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q92956}.
uniprot
proteins
transmembrane_region
TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins