Gria4
entrez
14802
canonical
uniprot
Q9Z2W8
canonical
ensembl
ENSMUSG00000025892
resolver
ensp
ENSMUSP00000027020
resolver
ensp
ENSMUSP00000066980
resolver
ensp
ENSMUSP00000129316
resolver
ensp
ENSMUSP00000148533
resolver
ensp
ENSMUSP00000160253
resolver
ensp
ENSMUSP00000160254
resolver
ensp
ENSMUSP00000189183
resolver
enst
ENSMUST00000027020
resolver
enst
ENSMUST00000063508
resolver
enst
ENSMUST00000163309
resolver
enst
ENSMUST00000212533
resolver
genesymbol
Gria4
resolver
genesymbol_syn
Glur4
resolver
uniprot
E9PX01
resolver
uniprot
G5E863
resolver
uniprot
Q6P9M7
resolver
uniprot
Q8C069
resolver
uniprot_entry
E9PX01_MOUSE
resolver
uniprot_entry
G5E863_MOUSE
resolver
uniprot_entry
GRIA4_MOUSE
resolver
uniprot_entry
Q8C069_MOUSE
resolver
uniprot_sec
Q6P9M7
resolver
amino_acid_sequence
MRIICRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVTKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDAPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASDLP
uniprot
proteins
function
FUNCTION: Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (By similarity). {ECO:0000250|UniProtKB:P19493, ECO:0000250|UniProtKB:P42262, ECO:0000250|UniProtKB:P48058}.
uniprot
proteins
mass_dalton
100847
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Depalmitoylated upon L-glutamate stimulation. ZDHHC3/GODZ specifically palmitoylates Cys-611, which leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. {ECO:0000250|UniProtKB:P23819}.; PTM: Phosphorylated at Ser-862 by PRKCG; phosphorylation increases plasma membrane-associated GRI4 expression. {ECO:0000250|UniProtKB:P19493}.
uniprot
proteins
protein_family
GRIA4 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16129400
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33981040
uniprot
proteins
sequence_length
902
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P19493}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19493}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P19493}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19493}. Cell projection, dendrite {ECO:0000250|UniProtKB:P19493}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P42262}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P42262}.
uniprot
proteins
transmembrane_region
TRANSMEM 545..565; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 618..638; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 814..834; /note="Helical; Name=M4"; /evidence="ECO:0000250
uniprot
proteins