Samd7
entrez
75953
canonical
uniprot
Q8C8Y5
canonical
ensembl
ENSMUSG00000051860
resolver
ensp
ENSMUSP00000103897
resolver
genesymbol
Samd7
resolver
uniprot
F8WHA0
resolver
uniprot
G3UXH0
resolver
uniprot_entry
SAMD7_MOUSE
resolver
uniprot_sec
F8WHA0
resolver
uniprot_sec
G3UXH0
resolver
amino_acid_sequence
MTNPMMSVSSLLTSGQQKVPMVPSPFGPPIVDRDVLSSSIAPTDPSQFCVPSQFGSSGLPNANMPNPLSSHFYSGWGILPPEPIKAVTTRNEMFERHHAARAEMEMYSLYQQRRMERVNPKGLSGLGIPLFYGSSCLGGPTGFQGRSTLPASDVHLHRSTFRHLQGNPILLATRPHFTECWGQKYRLRRGAVYQKPPESDTESFKSQAEEKSSSQMPTLSYEEEEYIKDPDIEVDNQQKPRVADGKPTTVPANPHGELHTHQRKPSSLEANAWDDGKGKPSEQVYEGCDGKNGVFRPVSILPLSGTHEQVALRENCSLSDIQKWTVDDVYNFIRSLPGCSDYAQVFKDHAIDGETLPLLTEQHLRGTMGLKLGPALKIQSQVSQHVGNMFCKKLPSLPTHARQAFDQPADTSPLLDMSSWSDGLSIPGPQDLLSPKRTEQDVMRN
uniprot
proteins
function
FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells (PubMed:28900001, PubMed:33603070). Via its association with the PRC1-like complex, promotes epigenetic repressive marks H3K27me3 and H2AK119ub marks in nonrod genes, silencing their transcription (PubMed:28900001). Represses Crx-controlled photoreceptor-specific gene expression (PubMed:23565263). {ECO:0000269|PubMed:23565263, ECO:0000269|PubMed:28900001, ECO:0000269|PubMed:33603070}.
uniprot
proteins
mass_dalton
49259
uniprot
proteins
mutagenesis
MUTAGEN 328; /note="D->V: Decreased repression of CRX-controlled gene expression."; /evidence="ECO:0000269|PubMed:38272031"; MUTAGEN 372; /note="L->R: Disrupts oligomerization and localization to nuclear polycomb bodies."; /evidence="ECO:0000269|PubMed:28900001
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23565263
uniprot
proteins
pubmed
28900001
uniprot
proteins
pubmed
33603070
uniprot
proteins
pubmed
38272031
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23565263, ECO:0000269|PubMed:28900001}. Cytoplasm {ECO:0000269|PubMed:23565263}. Note=Co-localizes with PHC2 and RNF2 in nuclear polycomb bodies. {ECO:0000269|PubMed:28900001}.
uniprot
proteins