SVIP
entrez
258010
canonical
uniprot
Q8NHG7
canonical
ensembl
ENSG00000198168
resolver
ensp
ENSP00000346130
resolver
ensp
ENSP00000721916
resolver
ensp
ENSP00000764111
resolver
enst
ENST00000354193
resolver
genesymbol
SVIP
resolver
hgnc
HGNC:25238
resolver
uniprot_entry
SVIP_HUMAN
resolver
amino_acid_sequence
MGLCFPCPGESAPPTPDLEEKRAKLAEAAERRQKEAASRGILDVQSVQEKRKKKEKIEKQIATSGPPPEGGLRWTVS
uniprot
proteins
function
FUNCTION: Negative regulator of the ER-associated degradation pathway (ERAD) of misfolded proteins. It competes with AMFR/gp78 for binding VCP/p97, and inhibits AMFR/gp78-VCP/p97 complex formation that is required for degradation of ERAD substrates (PubMed:17872946). Involved in the regulation of adrenal cortisol and dehydroepiandrosterone (DHEA) biosynthesis (PubMed:35042898). {ECO:0000269|PubMed:17872946, ECO:0000269|PubMed:35042898}.
uniprot
proteins
mass_dalton
8443
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Loss of myristoylation. Does not localize to membranes but is exclusively localized in the cytosol. Has no effect on protein degradation by ERAD pathway."; /evidence="ECO:0000269|PubMed:17872946, ECO:0000269|PubMed:39117616"; MUTAGEN 4; /note="C->S: Decreased palmitoylation. Loss of palmitoylation; when associated in cis with S-7."; /evidence="ECO:0000269|PubMed:39117616"; MUTAGEN 7; /note="C->S: Decreased palmitoylation. Loss of palmitoylation; when associated in cis with S-4."; /evidence="ECO:0000269|PubMed:39117616
uniprot
proteins
protein_family
SVIP family
uniprot
proteins
pubmed
17872946
uniprot
proteins
pubmed
21896481
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
33479240
uniprot
proteins
pubmed
35042898
uniprot
proteins
pubmed
39117616
uniprot
proteins
sequence_length
77
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:17872946}; Lipid-anchor {ECO:0000269|PubMed:17872946}. Smooth endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P0C0A9}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0C0A9}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P0C0A9}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0C0A9}. Cell membrane {ECO:0000250|UniProtKB:P0C0A9}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0C0A9}. Lysosome membrane {ECO:0000269|PubMed:35042898}.
uniprot
proteins