GPR12
entrez
2835
canonical
uniprot
P47775
canonical
ensembl
ENSG00000132975
resolver
ensp
ENSP00000370844
resolver
ensp
ENSP00000384932
resolver
ensp
ENSP00000551805
resolver
enst
ENST00000381436
resolver
enst
ENST00000405846
resolver
enst
ENST00000881746
resolver
genesymbol
GPR12
resolver
hgnc
HGNC:4466
resolver
uniprot
A8K2F5
resolver
uniprot
B4DG25
resolver
uniprot
Q5T8P3
resolver
uniprot_entry
A8K2F5_HUMAN
resolver
uniprot_entry
B4DG25_HUMAN
resolver
uniprot_entry
GPR12_HUMAN
resolver
uniprot_sec
Q5T8P3
resolver
amino_acid_sequence
MNEDLKVNLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLAQRARSPSDV
uniprot
proteins
function
FUNCTION: Brain-specific G protein-coupled receptor involved in regulating diverse physiological processes including neurite outgrowth, meiotic arrest, and lipid and carbohydrate metabolism (By similarity). Functions as a receptor with constitutive G(s)-mediated signaling activity that stimulates cyclic AMP (cAMP) production (PubMed:36593162). Also engages the G(i)/G(o) pathway, which counteracts the cAMP increase driven by G(s) activation (PubMed:12220620). Additionally, two lipids sphingosylphosphorylcholine (SPC) and sphingosine-1-phosphate (S1P) may act as endogenous ligand and activate GPR12 (PubMed:12220620). {ECO:0000250|UniProtKB:P35412, ECO:0000269|PubMed:12220620, ECO:0000269|PubMed:36593162}.
uniprot
proteins
mass_dalton
36730
uniprot
proteins
mutagenesis
MUTAGEN 47; /note="W->A: Greatly decreased constitutive activity of GPR12."; /evidence="ECO:0000269|PubMed:36593162"; MUTAGEN 181; /note="C->S: Greatly decreased constitutive activity of GPR12."; /evidence="ECO:0000269|PubMed:36593162"; MUTAGEN 188; /note="C->S: Greatly decreased constitutive activity of GPR12."; /evidence="ECO:0000269|PubMed:36593162"; MUTAGEN 284; /note="Y->L: Greatly decreased constitutive activity of GPR12."; /evidence="ECO:0000269|PubMed:36593162
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12220620
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19286662
uniprot
proteins
pubmed
36593162
uniprot
proteins
pubmed
8530049
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..71; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:36593162"; TRANSMEM 78..103; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:36593162"; TRANSMEM 114..136; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:36593162"; TRANSMEM 154..176; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:36593162"; TRANSMEM 193..217; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:36593162"; TRANSMEM 252..274; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:36593162"; TRANSMEM 281..303; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:36593162
uniprot
proteins