Cryz
entrez
12972
canonical
uniprot
P47199
canonical
ensembl
ENSMUSG00000028199
resolver
ensp
ENSMUSP00000029850
resolver
ensp
ENSMUSP00000142105
resolver
ensp
ENSMUSP00000189845
resolver
ensp
ENSMUSP00000189853
resolver
enst
ENSMUST00000029850
resolver
enst
ENSMUST00000192462
resolver
genesymbol
Cryz
resolver
uniprot
Q62508
resolver
uniprot
Q99L63
resolver
uniprot_entry
QOR_MOUSE
resolver
uniprot_sec
Q62508
resolver
uniprot_sec
Q99L63
resolver
amino_acid_sequence
MATGQKLMRAIRVFEFGGPEVLKLQSDVVVPVPQSHQVLIKVHACGVNPVETYIRSGAYSRKPALPYTPGSDVAGIIESVGDKVSAFKKGDRVFCYSTVSGGYAEFALAADDTIYPLPETLNFRQGAALGIPYFTACRALFHSARARAGESVLVHGASGGVGLATCQIARAHGLKVLGTAGSEEGKKLVLQNGAHEVFNHKEANYIDKIKMSVGDKDKGVDVIIEMLANENLSNDLKLLSHGGRVVVVGCRGPIEINPRDTMAKETSIIGVSLSSSTKEEFQQFAGLLQAGIEKGWVKPVIGSEYPLEKAAQAHEDIIHGSGKTGKMILLL
uniprot
proteins
ec_number
1.6.5.5
uniprot
proteins
function
FUNCTION: Multifunctional crystallin endowed with unrelated mRNA stabilization and enzymatic oxidoreductase activities (By similarity). Binds (AU)-rich elements (ARE) in the 3'-UTR of target mRNA to enhance their stability (PubMed:19657324). Upon metabolic acidosis, stabilizes the mRNA encoding SLC12A1 a cotransporter involved in transepithelial NH4(+) reabsorption in the medullary thick ascending limb in kidney (PubMed:19657324). In response to acidosis, also participates to the adaptive increase in renal ammoniagenesis by stabilizing the mRNAs of enzymes involved in glutamine catabolism (By similarity). By the same mechanism, it also regulates the expression of the antiapoptotic protein BCL2. Beside its mRNA stabilization activity, also catalyzes the reduction of orthoquinones such as 1,2-naphthoquinone or 9,10-phenanthrenequinone in the presence of NADPH in vitro and could be involved in the detoxification of xenobiotics and protection against oxidative stress (By similarity). {ECO:0000250|UniProtKB:Q08257, ECO:0000250|UniProtKB:Q6AYT0, ECO:0000269|PubMed:19657324}.
uniprot
proteins
mass_dalton
35269
uniprot
proteins
protein_family
Quinone oxidoreductase subfamily
uniprot
proteins
protein_family
Zinc-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19657324
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
8170370
uniprot
proteins
pubmed
8645260
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q08257}.
uniprot
proteins