GRK7
entrez
131890
canonical
uniprot
Q8WTQ7
canonical
ensembl
ENSG00000114124
resolver
ensp
ENSP00000264952
resolver
ensp
ENSP00000508022
resolver
enst
ENST00000264952
resolver
enst
ENST00000682958
resolver
genesymbol
GRK7
resolver
genesymbol_syn
GPRK7
resolver
hgnc
HGNC:17031
resolver
uniprot_entry
GRK7_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by phosphorylation of Ser-36. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLCEQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCEEGNSSKSGVCLLL
uniprot
proteins
ec_number
2.7.11.14
uniprot
proteins
function
FUNCTION: Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). {ECO:0000269|PubMed:15946941}.
uniprot
proteins
mass_dalton
62212
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="S->A: No effect on kinase activity. Increase kinase activity; when associated with A-36."; /evidence="ECO:0000269|PubMed:15946941"; MUTAGEN 36; /note="S->A: No effect on kinase activity. Increase kinase activity; when associated with A-23."; /evidence="ECO:0000269|PubMed:15946941
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated in vitro at Ser-490. Phosphorylation at Ser-36 is regulated by light and activated by cAMP. {ECO:0000269|PubMed:18803695}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
GPRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11717351
uniprot
proteins
pubmed
11754336
uniprot
proteins
pubmed
15946941
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18803695
uniprot
proteins
sequence_length
553
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8WMV0}; Lipid-anchor {ECO:0000250|UniProtKB:Q8WMV0}.
uniprot
proteins