Rnh1
entrez
100360501
canonical
uniprot
P29315
canonical
ensembl
ENSRNOG00000016416
resolver
ensp
ENSRNOP00000022241
resolver
ensp
ENSRNOP00000098900
resolver
enst
ENSRNOT00000022241
resolver
enst
ENSRNOT00000154403
resolver
genesymbol
Rnh1
resolver
genesymbol_syn
LOC100360501
resolver
genesymbol_syn
Rnh
resolver
genesymbol_syn
rnase-inh
resolver
uniprot
A0ABK0KWL7
resolver
uniprot
E2RUH2
resolver
uniprot
F7F8M8
resolver
uniprot
Q6IRS9
resolver
uniprot_entry
A0ABK0KWL7_RAT
resolver
uniprot_entry
E2RUH2_RAT
resolver
uniprot_entry
F7F8M8_RAT
resolver
uniprot_entry
RINI_RAT
resolver
uniprot_sec
Q6IRS9
resolver
amino_acid_sequence
MSLDIQCEQLSDARWTELLPLIQQYQVVRLDDCGLTEVRCKDIRSAIQANPALTELSLRTNELGDAGVGLVLQGLQNPTCKIQKLSLQNCSLTEAGCGVLPDVLRSLSTLRELHLNDNPLGDEGLKLLCEGLRDPQCRLEKLQLEYCNLTATSCEPLASVLRVKPDFKELVLSNNDFHEAGIHTLCQGLKDSACQLESLKLENCGITSANCKDLCDVVASKASLQELDLGSNKLGNTGIAALCSGLLLPSCRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEGAQLLCESLLEPGCQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVELCKALGYPDTVLRVLWLGDCDVTDSGCSSLATVLLANRSLRELDLSNNCMGDNGVLQLLESLKQPSCILQQLVLYDIYWTDEVEDQLRALEEERPSLRIIS
uniprot
proteins
function
FUNCTION: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:1536887). May play a role in redox homeostasis. Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (By similarity). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (By similarity). {ECO:0000250|UniProtKB:P13489, ECO:0000269|PubMed:1536887}.
uniprot
proteins
mass_dalton
49974
uniprot
proteins
pubmed
1536887
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P13489}. Nucleus {ECO:0000250|UniProtKB:P13489}. Note=Localizes in the cytoplasm in absence of stress; translocates to the nucleus in response to stress. {ECO:0000250|UniProtKB:P13489}.
uniprot
proteins