RMND5B
entrez
64777
canonical
uniprot
Q96G75
canonical
ensembl
ENSG00000145916
resolver
ensp
ENSP00000320623
resolver
ensp
ENSP00000420875
resolver
ensp
ENSP00000437630
resolver
ensp
ENSP00000560067
resolver
ensp
ENSP00000610763
resolver
enst
ENST00000542098
resolver
genesymbol
RMND5B
resolver
hgnc
HGNC:26181
resolver
uniprot
B3KSG5
resolver
uniprot
F5H6G4
resolver
uniprot
Q1HE27
resolver
uniprot
Q6UVY7
resolver
uniprot
Q9H6F6
resolver
uniprot_entry
B3KSG5_HUMAN
resolver
uniprot_entry
F5H6G4_HUMAN
resolver
uniprot_entry
RMD5B_HUMAN
resolver
uniprot_sec
Q1HE27
resolver
uniprot_sec
Q6UVY7
resolver
uniprot_sec
Q9H6F6
resolver
amino_acid_sequence
MEQCACVERELDKVLQKFLTYGQHCERSLEELLHYVGQLRAELASAALQGTPLSATLSLVMSQCCRKIKDTVQKLASDHKDIHSSVSRVGKAIDRNFDSEICGVVSDAVWDAREQQQQILQMAIVEHLYQQGMLSVAEELCQESTLNVDLDFKQPFLELNRILEALHEQDLGPALEWAVSHRQRLLELNSSLEFKLHRLHFIRLLAGGPAKQLEALSYARHFQPFARLHQREIQVMMGSLVYLRLGLEKSPYCHLLDSSHWAEICETFTRDACSLLGLSVESPLSVSFASGCVALPVLMNIKAVIEQRQCTGVWNHKDELPIEIELGMKCWYHSVFACPILRQQTSDSNPPIKLICGHVISRDALNKLINGGKLKCPYCPMEQNPADGKRIIF
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). {ECO:0000269|PubMed:29911972}.
uniprot
proteins
mass_dalton
44414
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25793641
uniprot
proteins
pubmed
29911972
uniprot
proteins
sequence_length
393
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25793641}.
uniprot
proteins