RTN4
entrez
57142
canonical
uniprot
Q9NQC3
canonical
ensembl
ENSG00000115310
resolver
ensp
ENSP00000322147
resolver
ensp
ENSP00000337838
resolver
ensp
ENSP00000349944
resolver
ensp
ENSP00000350365
resolver
ensp
ENSP00000378107
resolver
ensp
ENSP00000378109
resolver
ensp
ENSP00000384471
resolver
ensp
ENSP00000385650
resolver
genesymbol
RTN4
resolver
genesymbol_syn
KIAA0886
resolver
genesymbol_syn
NOGO
resolver
hgnc
HGNC:14085
resolver
uniprot
O94962
resolver
uniprot
Q7L7Q5
resolver
uniprot
Q7L7Q6
resolver
uniprot
Q7L7Q8
resolver
uniprot
Q8IUA4
resolver
uniprot
Q96B16
resolver
uniprot
Q9BXG5
resolver
uniprot
Q9H212
resolver
uniprot
Q9H3I3
resolver
uniprot
Q9UQ42
resolver
uniprot
Q9Y293
resolver
uniprot
Q9Y2Y7
resolver
uniprot
Q9Y5U6
resolver
uniprot_entry
RTN4_HUMAN
resolver
uniprot_sec
O94962
resolver
uniprot_sec
Q7L7Q5
resolver
uniprot_sec
Q7L7Q6
resolver
uniprot_sec
Q7L7Q8
resolver
uniprot_sec
Q8IUA4
resolver
uniprot_sec
Q96B16
resolver
uniprot_sec
Q9BXG5
resolver
uniprot_sec
Q9H212
resolver
uniprot_sec
Q9H3I3
resolver
uniprot_sec
Q9UQ42
resolver
uniprot_sec
Q9Y293
resolver
uniprot_sec
Q9Y2Y7
resolver
uniprot_sec
Q9Y5U6
resolver
amino_acid_sequence
MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEPVIRSSAENMDLKEQPGNTISAGQEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPTEGTLQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEIIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLESFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE
uniprot
proteins
function
FUNCTION: Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}.
uniprot
proteins
mass_dalton
129931
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
10667780
uniprot
proteins
pubmed
10667797
uniprot
proteins
pubmed
10773680
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11126360
uniprot
proteins
pubmed
11201742
uniprot
proteins
pubmed
11866689
uniprot
proteins
pubmed
11891768
uniprot
proteins
pubmed
12488097
uniprot
proteins
pubmed
12811824
uniprot
proteins
pubmed
15034570
uniprot
proteins
pubmed
15286784
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16835300
uniprot
proteins
pubmed
16877707
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
16965550
uniprot
proteins
pubmed
16979658
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19052207
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19665976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19699797
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21183689
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24262037
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25612671
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26906412
uniprot
proteins
pubmed
27619977
uniprot
proteins
pubmed
27786289
uniprot
proteins
pubmed
32075961
uniprot
proteins
pubmed
33826365
uniprot
proteins
sequence_length
1192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform A]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289}; Multi-pass membrane protein {ECO:0000255}. Cell membrane; Multi-pass membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000269|PubMed:27786289}. Synapse {ECO:0000250|UniProtKB:Q99P72}. Note=Anchored to the membrane of the endoplasmic reticulum (ER) through 2 putative transmembrane domains. Localizes throughout the ER tubular network (PubMed:27619977). Co-localizes with TMEM33 at the ER sheets. {ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:27619977}.; SUBCELLULAR LOCATION: [Isoform B]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27786289}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:15034570}; Multi-pass membrane protein {ECO:0000255}; Extracellular side {ECO:0000269|PubMed:15034570}. Cell junction {ECO:0000269|PubMed:21183689}. Note=Mainly located on endoplasmic reticulum tubules and sheet edges (PubMed:27786289). Upon ICAM1 engagement, redistributed toward endothelial junctions where interacts with CDH5 (PubMed:21183689). {ECO:0000269|PubMed:21183689, ECO:0000269|PubMed:27786289}.; SUBCELLULAR LOCATION: [Isoform C]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25612671}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 1019..1039; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1134..1154; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins