Hsf2bp
entrez
74377
canonical
uniprot
Q9D4G2
canonical
ensembl
ENSMUSG00000002076
resolver
ensp
ENSMUSP00000002145
resolver
ensp
ENSMUSP00000115909
resolver
ensp
ENSMUSP00000157466
resolver
enst
ENSMUST00000002145
resolver
enst
ENSMUST00000133308
resolver
enst
ENSMUST00000238192
resolver
genesymbol
Hsf2bp
resolver
genesymbol_syn
Meilb2
resolver
uniprot
A0A3T0ZJB3
resolver
uniprot
F6UJ67
resolver
uniprot_entry
A0A3T0ZJB3_MOUSE
resolver
uniprot_entry
F6UJ67_MOUSE
resolver
uniprot_entry
HSF2B_MOUSE
resolver
amino_acid_sequence
MAATVGDGSGTEEACRNMESKEEFVKVRKKDLERLTTEVMQIRDFLPRILNGELLESFQKLKMVEKNLERKEQELEQLIMDREHFKARLETAQADSGREKKEKLALRQQLNEAKQQLLQQAEYCTQMGAVTCTLLWGVSSSEEVVKTILGGDKALKFFNITGQTMESFVKSLDGDVKEVDSDENQFVFALAGIVTNVAAIACGREFLVNSSRVLLDTMLQLLGDLKPGQCTKLKVLMLMSLYNVSINSKGLKYITESPGFIPLLWWLLSDPDAEVCLHTLRLIQSVVLEPDVFSKVASELQSSLPLQRILAMSKSRNSHLQSAAQELLEDLRALDCNV
uniprot
proteins
function
FUNCTION: Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (PubMed:30760716, PubMed:31242413, PubMed:32345962, PubMed:32463460). Required for proper recombinase recruitment in female meiosis (PubMed:30760716, PubMed:32845237). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (PubMed:23707421). May be involved in modulating HSF2 activation in testis (By similarity). {ECO:0000250|UniProtKB:O75031, ECO:0000269|PubMed:23707421, ECO:0000269|PubMed:30760716, ECO:0000269|PubMed:31242413, ECO:0000269|PubMed:32345962, ECO:0000269|PubMed:32463460, ECO:0000269|PubMed:32845237}.
uniprot
proteins
mass_dalton
37963
uniprot
proteins
mutagenesis
MUTAGEN 167; /note="S->L: Mutant females show reduced fertility with smaller litter sizes. Produces DNA repair defects during meiotic prophase I. Reduces loading of BRME1 and HSF2BP at the recombination nodules. Males show a slight non-significant reduction in fertility. No effect on interaction with BRCA2 and BRME1. No effect on subcellular location. Reduces BRME1 expression."; /evidence="ECO:0000269|PubMed:32845237"; MUTAGEN 204; /note="R->T: Abolishes interaction with BRCA2 and location to double-strand breaks in chromosomes."; /evidence="ECO:0000269|PubMed:32345962
uniprot
proteins
post_translational_modification
PTM: Sumoylated by UBE2I in response to MEKK1-mediated stimuli. {ECO:0000250|UniProtKB:O75031}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23707421
uniprot
proteins
pubmed
30760716
uniprot
proteins
pubmed
31242413
uniprot
proteins
pubmed
32345962
uniprot
proteins
pubmed
32460033
uniprot
proteins
pubmed
32463460
uniprot
proteins
pubmed
32845237
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23707421, ECO:0000269|PubMed:32845237}. Chromosome {ECO:0000269|PubMed:30760716, ECO:0000269|PubMed:31242413, ECO:0000269|PubMed:32345962, ECO:0000269|PubMed:32463460, ECO:0000269|PubMed:32845237}. Note=Localizes on double-strand breaks (DSBs) in mitotic and meiotic chromosomes. {ECO:0000269|PubMed:30760716, ECO:0000269|PubMed:31242413, ECO:0000269|PubMed:32345962, ECO:0000269|PubMed:32463460, ECO:0000269|PubMed:32845237}.
uniprot
proteins