ERBIN
entrez
55914
canonical
uniprot
Q96RT1
canonical
ensembl
ENSG00000112851
resolver
ensp
ENSP00000284037
resolver
ensp
ENSP00000370325
resolver
ensp
ENSP00000370330
resolver
ensp
ENSP00000422015
resolver
ensp
ENSP00000422766
resolver
ensp
ENSP00000425728
resolver
ensp
ENSP00000426632
resolver
ensp
ENSP00000514083
resolver
ensp
ENSP00000514089
resolver
ensp
ENSP00000544199
resolver
ensp
ENSP00000595712
resolver
enst
ENST00000699005
resolver
enst
ENST00000699010
resolver
genesymbol
ERBIN
resolver
genesymbol_syn
ERBB2IP
resolver
genesymbol_syn
KIAA1225
resolver
genesymbol_syn
LAP2
resolver
hgnc
HGNC:15842
resolver
uniprot
A0A8V8TML4
resolver
uniprot
A0A8V8TPC7
resolver
uniprot
A0AVR1
resolver
uniprot
B4E3F1
resolver
uniprot
B7ZLV9
resolver
uniprot
E7EQW9
resolver
uniprot
E9PCR8
resolver
uniprot
Q1RMD0
resolver
uniprot
Q86W38
resolver
uniprot
Q9NR18
resolver
uniprot
Q9NW48
resolver
uniprot
Q9ULJ5
resolver
uniprot_entry
A0A8V8TML4_HUMAN
resolver
uniprot_entry
A0A8V8TPC7_HUMAN
resolver
uniprot_entry
ERBIN_HUMAN
resolver
uniprot_sec
A0AVR1
resolver
uniprot_sec
B4E3F1
resolver
uniprot_sec
B7ZLV9
resolver
uniprot_sec
E7EQW9
resolver
uniprot_sec
E9PCR8
resolver
uniprot_sec
Q1RMD0
resolver
uniprot_sec
Q86W38
resolver
uniprot_sec
Q9NR18
resolver
uniprot_sec
Q9NW48
resolver
uniprot_sec
Q9ULJ5
resolver
amino_acid_sequence
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKFKAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVKITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSVSSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKKHPQTSSSGDPCQDGIFISGQQNYSSATLSHKDVPPDSLMKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS
uniprot
proteins
function
FUNCTION: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). Acts as a mediator of keratinocyte differentiation by sequestering SHOC2 away from ERK-activating RAS complexes (PubMed:23524970). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728, ECO:0000269|PubMed:23524970}.
uniprot
proteins
mass_dalton
158298
uniprot
proteins
protein_family
LAP (LRR and PDZ) protein family
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
10878805
uniprot
proteins
pubmed
11375975
uniprot
proteins
pubmed
11821434
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12444095
uniprot
proteins
pubmed
12446668
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16203728
uniprot
proteins
pubmed
16737969
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23524970
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
39256359
uniprot
proteins
sequence_length
1412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, hemidesmosome {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:11375975}. Nucleus membrane {ECO:0000250}. Basolateral cell membrane {ECO:0000269|PubMed:16203728}. Cytoplasm {ECO:0000269|PubMed:23524970}. Cell membrane {ECO:0000269|PubMed:23524970}. Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity). {ECO:0000250}.
uniprot
proteins