DNAJC10
entrez
54431
canonical
uniprot
Q8IXB1
canonical
ensembl
ENSG00000077232
resolver
ensp
ENSP00000264065
resolver
ensp
ENSP00000479930
resolver
genesymbol
DNAJC10
resolver
genesymbol_syn
ERDJ5
resolver
hgnc
HGNC:24637
resolver
uniprot
Q17RJ6
resolver
uniprot
Q3B7W8
resolver
uniprot
Q4ZG06
resolver
uniprot
Q53QT7
resolver
uniprot
Q6UWZ6
resolver
uniprot
Q86T61
resolver
uniprot
Q8NC82
resolver
uniprot
Q8TD87
resolver
uniprot
Q96K38
resolver
uniprot
Q96K44
resolver
uniprot
Q96K54
resolver
uniprot
Q9NSY6
resolver
uniprot_entry
DJC10_HUMAN
resolver
uniprot_sec
Q17RJ6
resolver
uniprot_sec
Q3B7W8
resolver
uniprot_sec
Q4ZG06
resolver
uniprot_sec
Q53QT7
resolver
uniprot_sec
Q6UWZ6
resolver
uniprot_sec
Q86T61
resolver
uniprot_sec
Q8NC82
resolver
uniprot_sec
Q8TD87
resolver
uniprot_sec
Q96K38
resolver
uniprot_sec
Q96K44
resolver
uniprot_sec
Q96K54
resolver
uniprot_sec
Q9NSY6
resolver
amino_acid_sequence
MGVWLNKDDYIRDLKRIILCFLIVYMAILVGTDQDFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHGDFLKINRAYEVLKDEDLRKKYDKYGEKGLEDNQGGQYESWNYYRYDFGIYDDDPEIITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAPVKYHGDRSKESLVSFAMQHVRSTVTELWTGNFVNSIQTAFAAGIGWLITFCSKGGDCLTSQTRLRLSGMLDGLVNVGWMDCATQDNLCKSLDITTSTTAYFPPGATLNNKEKNSILFLNSLDAKEIYLEVIHNLPDFELLSANTLEDRLAHHRWLLFFHFGKNENSNDPELKKLKTLLKNDHIQVGRFDCSSAPDICSNLYVFQPSLAVFKGQGTKEYEIHHGKKILYDILAFAKESVNSHVTTLGPQNFPANDKEPWLVDFFAPWCPPCRALLPELRRASNLLYGQLKFGTLDCTVHEGLCNMYNIQAYPTTVVFNQSNIHEYEGHHSAEQILEFIEDLMNPSVVSLTPTTFNELVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSIDCQQYHSFCAQENVQRYPEIRFFPPKSNKAYHYHSYNGWNRDAYSLRIWGLGFLPQVSTDLTPQTFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLARMIKGKVKAGKVDCQAYAQTCQKAGIRAYPTVKFYFYERAKRNFQEEQINTRDAKAIAALISEKLETLRNQGKRNKDEL
uniprot
proteins
ec_number
1.8.4.2
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum disulfide reductase that collaborates directly with the chaperone BIP/HSPA5 (GRP78) to maintain protein quality control by facilitating either the correct folding or the targeted degradation of misfolded proteins (PubMed:12411443, PubMed:23769672, PubMed:37739037). Essential for efficient maturation of newly synthesized polypeptides in the endoplasmic reticulum, binds to substrate proteins and specifically catalyzes the reduction and removal of improper (non-native) disulfide bonds during the folding process (PubMed:23769672, PubMed:37739037). In endoplasmic reticulum-associated degradation (ERAD), DNAJC10 reduces incorrect disulfide bonds specifically in misfolded glycoproteins that have been recognized by EDEM1, a key component of the ERAD pathway, thereby enabling their retrotranslocation and degradation (PubMed:18400946). Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress (PubMed:19122239). {ECO:0000269|PubMed:12411443, ECO:0000269|PubMed:18400946, ECO:0000269|PubMed:19122239, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:37739037}.
uniprot
proteins
mass_dalton
91080
uniprot
proteins
mutagenesis
MUTAGEN 63; /note="H->Q: Prevents interaction with HSPA5, leading to prolonged interaction with substrate proteins."; /evidence="ECO:0000269|PubMed:23769672"; MUTAGEN 161; /note="C->A: Abolishes disulfide reductase activity; when associated with A-483; A-591 and A-703."; /evidence="ECO:0000269|PubMed:23769672"; MUTAGEN 483; /note="C->A: Abolishes disulfide reductase activity; when associated with A-161; A-591 and A-703."; /evidence="ECO:0000269|PubMed:23769672"; MUTAGEN 591; /note="C->A: Abolishes disulfide reductase activity; when associated with A-161; A-483 and A-703."; /evidence="ECO:0000269|PubMed:23769672"; MUTAGEN 703; /note="C->A: Abolishes disulfide reductase activity; when associated with A-161; A-483 and A-591."; /evidence="ECO:0000269|PubMed:23769672
uniprot
proteins
pubmed
12411443
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14587667
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18400946
uniprot
proteins
pubmed
19122239
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23769672
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
37739037
uniprot
proteins
sequence_length
793
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12411443, ECO:0000269|PubMed:23769672}.
uniprot
proteins