STX1A
entrez
6804
canonical
uniprot
Q16623
canonical
ensembl
ENSG00000106089
resolver
ensp
ENSP00000222812
resolver
ensp
ENSP00000378583
resolver
ensp
ENSP00000378584
resolver
ensp
ENSP00000378585
resolver
enst
ENST00000395154
resolver
enst
ENST00000395155
resolver
genesymbol
STX1A
resolver
genesymbol_syn
STX1
resolver
hgnc
HGNC:11433
resolver
uniprot
A0A0C4DFZ1
resolver
uniprot
A8MZ54
resolver
uniprot
O15447
resolver
uniprot
O15448
resolver
uniprot
Q12936
resolver
uniprot
Q75MD9
resolver
uniprot
Q75ME0
resolver
uniprot
Q7Z5K3
resolver
uniprot
Q9BPZ6
resolver
uniprot_entry
A0A0C4DFZ1_HUMAN
resolver
uniprot_entry
A8MZ54_HUMAN
resolver
uniprot_entry
Q75ME0_HUMAN
resolver
uniprot_entry
STX1A_HUMAN
resolver
uniprot_sec
O15447
resolver
uniprot_sec
O15448
resolver
uniprot_sec
Q12936
resolver
uniprot_sec
Q75MD9
resolver
uniprot_sec
Q7Z5K3
resolver
uniprot_sec
Q9BPZ6
resolver
amino_acid_sequence
MKDRTQELRTAKDSDDDDDVAVTVDRDRFMDEFFEQVEEIRGFIDKIAENVEEVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMSEYNATQSDYRERCKGRIQRQLEITGRTTTSEELEDMLESGNPAIFASGIIMDSSISKQALSEIETRHSEIIKLENSIRELHDMFMDMAMLVESQGEMIDRIEYNVEHAVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVILGIVIASTVGGIFA
uniprot
proteins
disease_involvement
DISEASE: Note=STX1A is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. {ECO:0000305|PubMed:9311751}.
uniprot
proteins
function
FUNCTION: Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057). Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity). {ECO:0000250|UniProtKB:O35526, ECO:0000269|PubMed:23091057, ECO:0000269|PubMed:26635000}.
uniprot
proteins
mass_dalton
33023
uniprot
proteins
mutagenesis
MUTAGEN 252; /note="K->R: Complete loss of sumoylation; when associated with R-253 and R-256."; /evidence="ECO:0000269|PubMed:26635000"; MUTAGEN 253; /note="K->R: Complete loss of sumoylation; when associated with R-252 and R-256."; /evidence="ECO:0000269|PubMed:26635000"; MUTAGEN 256; /note="K->R: Complete loss of sumoylation; when associated with R-252 and R-253."; /evidence="ECO:0000269|PubMed:26635000
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CK2 (By similarity). Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1. {ECO:0000250, ECO:0000269|PubMed:12730201}.; PTM: Sumoylated, sumoylation is required for regulation of synaptic vesicle endocytosis. {ECO:0000269|PubMed:26635000}.
uniprot
proteins
protein_family
Syntaxin family
uniprot
proteins
pubmed
10644452
uniprot
proteins
pubmed
11977160
uniprot
proteins
pubmed
12130530
uniprot
proteins
pubmed
12586365
uniprot
proteins
pubmed
12730201
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15459722
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15822905
uniprot
proteins
pubmed
23091057
uniprot
proteins
pubmed
26635000
uniprot
proteins
pubmed
7622072
uniprot
proteins
pubmed
9003414
uniprot
proteins
pubmed
9177791
uniprot
proteins
pubmed
9311751
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O35526}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:O35526}. Synapse, synaptosome {ECO:0000250|UniProtKB:O35526}. Cell membrane {ECO:0000250|UniProtKB:P32851}. Note=Colocalizes with KCNB1 at the cell membrane. {ECO:0000250|UniProtKB:P32851}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 266..286; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins