Large2
entrez
311202
canonical
uniprot
Q6P7A1
canonical
ensembl
ENSRNOG00000006353
resolver
ensp
ENSRNOP00000041797
resolver
ensp
ENSRNOP00000089432
resolver
ensp
ENSRNOP00000100953
resolver
enst
ENSRNOT00000051258
resolver
enst
ENSRNOT00000098647
resolver
enst
ENSRNOT00000147683
resolver
genesymbol
Large2
resolver
genesymbol_syn
Gyltl1b
resolver
uniprot
A0A8I6ACM6
resolver
uniprot
A0A8L2QLT7
resolver
uniprot
A0ABK0LCB2
resolver
uniprot_entry
A0A8I6ACM6_RAT
resolver
uniprot_entry
A0A8L2QLT7_RAT
resolver
uniprot_entry
A0ABK0LCB2_RAT
resolver
uniprot_entry
LARG2_RAT
resolver
amino_acid_sequence
MLPRGRPRALGAALLLLLLLVVGFFLFGRDPEYGLGTTATLDGDPYGSRNRSTSSLQLLLPPKCEMLHVAIVCAGYNSSREIITLMKSVLFYRKNPLHLHLITDAVARNILETLFRTWMVPAVVVSFYDAEELKPLVSWIPNKHYSGLYGLMKLVLPSVLPLSLARVIVLDTDVTFSSDIMELWALFGHFSDKQVVGLVENQSDWYLGNLWKNHRPWPALGRGFNTGVILLWLDRLQQIGWEQMWKLTAKRELLTLTATSLADQDIFNAVIKEHPELVHPLPCVWNVQLSDHTLAERCYLEAADLKVIHWNSPKKLRVKNKHAEFFRDLHLTFLGFDGKLLCRELFGCPNQFPPGVEQLQQALAQLDEEEPCFEFRQQQLTVHRVHITFLSHQPPPPRPHDVTLVAQLSMDRLQMLEALCRHWRGPMSLALYLTDAEAQQFLRFVETSPVLSARKDVAYHVVYRDGPLYPVNQLRNVALAQALTPYVFLSDIDFLPAYSLYDYLRASIEQLALGRRQRKAALVVPAFETLHYRFSFPNSKAELLTLLDAGSLHTFRYHEWPQGHASTDYTRWREAQAPYRVQWSADYEPYVVVPRDCPRYDPRFVGFGWNKVAHIIELDAQEYEFLVLPEAFSIHLPHAPSLDISRFRSSPTYRDCLQALKEEFHQDLSRRYGSAALKYLTALQQSRSRA
uniprot
proteins
ec_number
2.4.-.-
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.2.-
uniprot
proteins
function
FUNCTION: Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (By similarity). Supports the maturation of DAG1 more effectively than LARGE1 (By similarity). In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (By similarity). {ECO:0000250|UniProtKB:Q5XPT3, ECO:0000250|UniProtKB:Q8N3Y3}.
uniprot
proteins
mass_dalton
79309
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q5XPT3}.
uniprot
proteins
protein_family
Glycosyltransferase 49 family; Glycosyltransferase 8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
690
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q5XPT3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q5XPT3}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins