Gpr52
entrez
620246
canonical
uniprot
P0C5J4
canonical
ensembl
ENSMUSG00000118401
resolver
ensp
ENSMUSP00000158769
resolver
ensp
ENSMUSP00000363562
resolver
enst
ENSMUST00000238289
resolver
genesymbol
Gpr52
resolver
uniprot_entry
GPR52_MOUSE
resolver
amino_acid_sequence
MNESRWTEWRILNMSSSIVNVSEHHSCPLGFGHYSVEDVCIFETVVIVLLTFLIISGNLTVIFVFHCAPLLHHYTTSYFIQTMAYADLLVGVTCLVPTLSLLHYSTGVHESLTCQVFGYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIIMIWIYSCLIFLPSFFGWGKPGYHGDIFEWCATSWLTSAYFTCFIVCLLYAPAALVVCFTYFHIFKICRQHTKEINDRRARFPSHEVEASREAGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNCVIYSLSNSVFRLGLRRLSETMCTSCVCAKDQEAQDPKPRRRANSCSI
uniprot
proteins
function
FUNCTION: G protein-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (By similarity). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241, PubMed:28583861). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228). {ECO:0000250|UniProtKB:Q9Y2T5, ECO:0000269|PubMed:24587241, ECO:0000269|PubMed:25738228, ECO:0000269|PubMed:28583861}.
uniprot
proteins
mass_dalton
41343
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24587241
uniprot
proteins
pubmed
25738228
uniprot
proteins
pubmed
28583861
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 45..65; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 206..226; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 266..286; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 297..317; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins