Map2k6
entrez
26399
canonical
uniprot
P70236
canonical
ensembl
ENSMUSG00000020623
resolver
ensp
ENSMUSP00000020949
resolver
ensp
ENSMUSP00000097831
resolver
enst
ENSMUST00000020949
resolver
enst
ENSMUST00000100260
resolver
genesymbol
Map2k6
resolver
genesymbol_syn
Prkmk6
resolver
genesymbol_syn
Sapkk3
resolver
uniprot
A2AGS2
resolver
uniprot
Q543Z5
resolver
uniprot
Q60521
resolver
uniprot_entry
A2AGS2_MOUSE
resolver
uniprot_entry
MP2K6_MOUSE
resolver
uniprot_entry
Q543Z5_MOUSE
resolver
uniprot_entry
Q60521_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by dual phosphorylation on Ser-207 and Thr-211 in response to a variety of cellular stresses, including UV radiation, osmotic shock, hypoxia, inflammatory cytokines, interferon gamma (IFNG), and less often by growth factors. MAP2K6/MKK6 is activated by the majority of M3Ks, such as MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK3, MAP3K4/MEKK4, MAP3K7/TAK1, MAP3K11/MLK3 and MAP3K17/TAOK2. {ECO:0000269|PubMed:15644321}.
uniprot
proteins
amino_acid_sequence
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSADFVDFTSQCLKKNSKERPTYPELMQHPFFTVHESKAADVASFVKLILGD
uniprot
proteins
ec_number
2.7.12.2
uniprot
proteins
function
FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases. {ECO:0000269|PubMed:12151339, ECO:0000269|PubMed:12824301, ECO:0000269|PubMed:12893778, ECO:0000269|PubMed:15644321, ECO:0000269|PubMed:16387856, ECO:0000269|PubMed:16498455, ECO:0000269|PubMed:20004242}.
uniprot
proteins
mass_dalton
37432
uniprot
proteins
post_translational_modification
PTM: Weakly autophosphorylated. Phosphorylated at Ser-207 and Thr-211 by the majority of M3Ks, such as MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK3, MAP3K4/MEKK4, MAP3K7/TAK1, MAP3K11/MLK3 and MAP3K17/TAOK2. {ECO:0000250|UniProtKB:P52564}.; PTM: In response to genotoxic stress, MAP3K-phosphorylated MAP2K6 is ubiquitinated and degraded by the SCF(FBXO31) complex. {ECO:0000250|UniProtKB:P52564}.
uniprot
proteins
protein_family
MAP kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
12151339
uniprot
proteins
pubmed
12482988
uniprot
proteins
pubmed
12824301
uniprot
proteins
pubmed
12893778
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15644321
uniprot
proteins
pubmed
16387856
uniprot
proteins
pubmed
16498455
uniprot
proteins
pubmed
20004242
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8861944
uniprot
proteins
pubmed
9779990
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P52564}. Cytoplasm {ECO:0000250|UniProtKB:P52564}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P52564}. Note=Binds to microtubules. {ECO:0000250|UniProtKB:P52564}.
uniprot
proteins