Q8BZ21
uniprot
Q8BZ21
canonical
amino_acid_sequence
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRRTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDTKQSVDWNKLLKRAFEGLAETGGSTLKSIERFLKSQKDVSAACGGSAAPGFHQQLRLAIKRAVGHGRLLKDGPLYRLNTKAASAEGKEGCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKQPEELVSCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYANPIGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITVSSQSASSSEEGYLERIDGLDFCRDSNAPLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKKGNRKSSTSDWPTDNQDGWESKQENEERLFGSQEIMTERDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGVCPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEDEDEEADEGEKEEPQGQERELETRVKVGKSVSREKKDQESSSLIETDKKPEVKELASSSRLSKQALPRDSLPANSQPPRRGRCGRKNRKTQERFGDKDSKMLVDETLSASQEQYGDCEEKSETSQERFTEMEEQLAAPQVQADGKPDIPKGRFSESVELWRGQLKKSPETLKCRLPEGNDRLPCCYTDGDRAFFRGFSESSEEEEEPESPRSNSPPILTKPTLKRKKPILHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEMEEEEEEEEEESELFPRGYFHCLSSQDILRCQSSSKRPSKEEEEEEEESDDADDTPVLKPVSLLRKCDVNSASLEPDTSTPMKKKKGWPKGKSRKPIHWKKRPGRKPGFKLNQEIIAASAQECIVEPVVPIKPGRKPRTQENEEIVEVKEDLLEERKEEMHTEPDEEAEEEEDTTSSDIRAMSPLDSSNSPEAEPKEPEPEEEDEKPSDDQRQSEEEPQELEEQEQEEEDEVTTEANQNEDHDADDEDEGHLDSLKTKEPEEQPAREDDKEEPGIQGSFLAANMQDSRENTKDKDEAEPDSEEDQPSHEASVVSETMPGSEEDHEEDSNTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTHTDEDPQMSMVEDCHASEHNSPISSIPSHPSQSVRSVNSPSMPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGSSICGNNSSQSSCSYGGLSSSSSLTQNSCVVTQQMANMGNSCSMLQQNTVQPAANCNIKSPQTCVVERPPSNQQPPPPPPPPPPPQQPQPPPQQQAAPQPPPPQPQQQQQQQQQPPPPQQQPQPPPPQQQPPLSQCSMNNSFTAAPMIMEIPESGSTGNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPLAGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSKSAPLPSATAHQQQLYGRSPPAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLNAMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTGPSHHSYMNAAGVPKQSLNGPYMRR
uniprot
proteins
ec_number
2.3.1.48
uniprot
proteins
function
FUNCTION: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro) (By similarity). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2 (PubMed:11742995). Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML (By similarity). May play a role in leukemogenic gene transcription (By similarity). {ECO:0000250|UniProtKB:Q92794, ECO:0000269|PubMed:11742995}.
uniprot
proteins
mass_dalton
224919
uniprot
proteins
post_translational_modification
PTM: Autoacetylated; autoacetylation at Lys-603 is required for proper function (By similarity). Acetylation at Lys-1007 and Lys-1014 is required for the interaction with MLLT1/ENL and MLLT3/AF9 (By similarity). {ECO:0000250|UniProtKB:Q9H7Z6}.; PTM: Crotonylated; crotonylation at Lys-1007 and Lys-1014 promotes the interaction with MLLT1/ENL and MLLT3/AF9. {ECO:0000250|UniProtKB:Q9H7Z6}.; PTM: Phosphorylation at Thr-369 by PKB/AKT1 inhibits its interaction with PML and negatively regulates its acetylation activity towards p53/TP53. {ECO:0000250}.
uniprot
proteins
protein_family
MYST (SAS/MOZ) family
uniprot
proteins
pubmed
11742995
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
2003
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q92794}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q92794}. Nucleus, PML body {ECO:0000250|UniProtKB:Q92794}. Note=Recruited into PML body after DNA damage. {ECO:0000250|UniProtKB:Q92794}.
uniprot
proteins