CCDC102B
entrez
79839
canonical
uniprot
Q68D86
canonical
ensembl
ENSG00000150636
resolver
ensp
ENSP00000353377
resolver
ensp
ENSP00000573483
resolver
genesymbol
CCDC102B
resolver
genesymbol_syn
C18orf14
resolver
hgnc
HGNC:26295
resolver
uniprot
A1A4H1
resolver
uniprot
Q7Z467
resolver
uniprot
Q8NDK7
resolver
uniprot
Q9H5C1
resolver
uniprot_entry
C102B_HUMAN
resolver
uniprot_sec
A1A4H1
resolver
uniprot_sec
Q7Z467
resolver
uniprot_sec
Q8NDK7
resolver
uniprot_sec
Q9H5C1
resolver
amino_acid_sequence
MNLDSIHRLIEETQIFQMQQSSIKSRGDMVAPASPPRDTCNTCFPLHGLQSHAAHNFCAHSYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQKEALEAKVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQNW
uniprot
proteins
function
FUNCTION: During interphase, forms fibers at the proximal ends of centrioles to maintain centrosome cohesion (PubMed:30404835). During mitosis, dissociates from the centrosome following phosphorylation to allow centrosome separation (PubMed:30404835). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:30404835}.
uniprot
proteins
mass_dalton
60448
uniprot
proteins
mutagenesis
MUTAGEN 21; /note="S->A: Substantial decrease in phosphorylation; when associated with A-22, A-34, A-135, A-142, A-194, A-210, A-401, A-404 and A-406."; /evidence="ECO:0000269|PubMed:30404835"; MUTAGEN 22; /note="S->A: Substantial decrease in phosphorylation; when associated with A-21, A-34, A-135, A-142, A-194, A-210, A-401, A-404 and A-406."; /evidence="ECO:0000269|PubMed:30404835"; MUTAGEN 34; /note="S->A: Substantial decrease in phosphorylation; when associated with A-21, A-22, A-135, A-142, A-194, A-210, A-401, A-404 and A-406."; /evidence="ECO:0000269|PubMed:30404835"; MUTAGEN 135; /note="S->A: Substantial decrease in phosphorylation; when associated with A-21, A-22, A-34, A-142, A-194, A-210, A-401, A-404 and A-406."; /evidence="ECO:0000269|PubMed:30404835"; MUTAGEN 142; /note="S->A: Substantial decrease in phosphorylation; when associated with A-21, A-22, A-34, A-135, A-194, A-210, A-401, A-404 and A-406."; /evidence="ECO:0000269|PubMed:30404835"; MUTAGEN 194; /note="S->A: Substantial decrease in phosphorylation; when associated with A-21, A-22, A-34, A-135, A-142, A-210, A-401, A-404 and A-406."; /evidence="ECO:0000269|PubMed:30404835"; MUTAGEN 210; /note="S->A: Substantial decrease in phosphorylation; when associated with A-21, A-22, A-34, A-135, A-142, A-194, A-401, A-404 and A-406."; /evidence="ECO:0000269|PubMed:30404835"; MUTAGEN 401; /note="S->A: Substantial decrease in phosphorylation; when associated with A-21, A-22, A-34, A-135, A-142, A-194, A-210, A-404 and A-406."; /evidence="ECO:0000269|PubMed:30404835"; MUTAGEN 404; /note="S->A: Substantial decrease in phosphorylation; when associated with A-21, A-22, A-34, A-135, A-142, A-194, A-210, A-401 and A-406."; /evidence="ECO:0000269|PubMed:30404835"; MUTAGEN 406; /note="S->A: Substantial decrease in phosphorylation; when associated with A-21, A-22, A-34, A-135, A-142, A-194, A-210, A-401 and A-404."; /evidence="ECO:0000269|PubMed:30404835
uniprot
proteins
post_translational_modification
PTM: Phosphorylated directly or indirectly by NEK2 during mitosis which causes dissociation of CCDC102B from the centrosome and allows for centrosome separation. {ECO:0000269|PubMed:30404835}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
30404835
uniprot
proteins
sequence_length
513
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:30404835}. Note=Concentrated at the proximal ends of centrioles where it forms fibers (PubMed:30404835). Centrosomal localization becomes weak when cells enter prophase and is significantly decreased in metaphase (PubMed:30404835). {ECO:0000269|PubMed:30404835}.
uniprot
proteins