Ch25h
entrez
12642
canonical
uniprot
Q9Z0F5
canonical
ensembl
ENSMUSG00000050370
resolver
ensp
ENSMUSP00000049683
resolver
enst
ENSMUST00000050562
resolver
genesymbol
Ch25h
resolver
uniprot
Q3TUM6
resolver
uniprot
Q8CHQ2
resolver
uniprot_entry
CH25H_MOUSE
resolver
uniprot_sec
Q3TUM6
resolver
uniprot_sec
Q8CHQ2
resolver
amino_acid_sequence
MGCYNGSELQDLGCSSQLLLQPLWDTIRTREAFTRSPIFPVTFSIITYVGFCLPFVVLDVLYPWVPILRRYKIHPDFSPSVKQLLPCLGLTLYQHLVFVFPVTLLHWVRSPALLPQEAPELVQLLSHVLICLLLFDTEIFAWHLLHHKVPWLYRTFHKVHHQNSSSFALATQYMSFWELLSLTFFDVLNVAVLRCHPLTIFTFHVINIWLSVEDHSGYDFPWSTHRLVPFGWYGGVAHHDMHHSQFNCNFAPYFTHWDKMLGTLRSAPLPESLCACGERCVNSRERCAVHLIQKKKQT
uniprot
proteins
ec_number
1.14.99.38
uniprot
proteins
function
FUNCTION: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:29033131, PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (PubMed:22999953). May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing (PubMed:9852097). In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation (PubMed:9852097). Required to restrain inflammation in macrophages: production of 25-hydroxycholesterol protects macrophages from cholesterol overload, thereby preventing mitochondrial DNA release and subsequent activation of the AIM2 inflammasome (PubMed:29033131). Interferon-stimulated gene which has broad antiviral activities against a wide range of enveloped viruses (By similarity). {ECO:0000250|UniProtKB:O95992, ECO:0000269|PubMed:22999953, ECO:0000269|PubMed:29033131, ECO:0000269|PubMed:9852097}.
uniprot
proteins
mass_dalton
34672
uniprot
proteins
mutagenesis
MUTAGEN 242..243; /note="HH->EE: Loss of function."; /evidence="ECO:0000269|PubMed:9852097
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:9852097}.
uniprot
proteins
protein_family
Sterol desaturase family
uniprot
proteins
pubmed
12543708
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22999953
uniprot
proteins
pubmed
29033131
uniprot
proteins
pubmed
9852097
uniprot
proteins
sequence_length
298
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9852097}; Multi-pass membrane protein {ECO:0000269|PubMed:9852097}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 124..144; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins