SPATA18
entrez
132671
canonical
uniprot
Q8TC71
canonical
ensembl
ENSG00000163071
resolver
ensp
ENSP00000295213
resolver
ensp
ENSP00000415309
resolver
ensp
ENSP00000521933
resolver
ensp
ENSP00000521935
resolver
ensp
ENSP00000521936
resolver
ensp
ENSP00000627095
resolver
genesymbol
SPATA18
resolver
genesymbol_syn
MIEAP
resolver
hgnc
HGNC:29579
resolver
uniprot
A0A140VKF4
resolver
uniprot
B4E2R0
resolver
uniprot
E5RLK1
resolver
uniprot
Q8IY48
resolver
uniprot
Q8N7D7
resolver
uniprot_entry
A0A140VKF4_HUMAN
resolver
uniprot_entry
MIEAP_HUMAN
resolver
uniprot_sec
B4E2R0
resolver
uniprot_sec
E5RLK1
resolver
uniprot_sec
Q8IY48
resolver
uniprot_sec
Q8N7D7
resolver
amino_acid_sequence
MAENLKRLVSNETLRTLQEKLDFWLKEYNTNTCDQNLNHCLELIEQVAKVQGQLFGILTAAAQEGGRNDGVETIKSRLLPWLEASFTAASLGKSVDSKVPSLQDTFDRERHKDPSPRDRDMQQLDSNLNSTRSQCNQVQDDLVETEKNLEESKNRSAISLLAAEEEINQLKKQLKSLQAQEDARHRNTDQRSSENRRSEPWSLEERKREQWNSLKQNADQQDTEAMSDYKKQLRNLKEEIAVLSAEKSALQGRSSRSRSPSPAPRSRSCSRSRSASPSTAVKVRRPSPNRSKLSNVARKAALLSRFSDSYSQARLDAQCLLRRCIDKAETVQRIIYIATVEAFHVAKMAFRHFKIHVRKSLTPSYVGSNDFENAVLDYVICHLDLYDSQSSVNDVIRAMNVNPKISFPPVVDFCLLSDFIQEICCIAFAMQALEPPLDIAYGADGEVFNDCKYRRSYDSDFTAPLVLYHVWPALMENDCVIMKGEAVTRRGAFWNSVRSVSRCRSRSLSPICPRSQIGLNTMSRSRSPSPIRCGLPRF
uniprot
proteins
function
FUNCTION: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage (PubMed:21264221, PubMed:21264228, PubMed:22292033, PubMed:22532927). Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen (PubMed:21264221, PubMed:21264228, PubMed:22292033, PubMed:22532927). Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (PubMed:21264228). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (PubMed:22292033). Binds cardiolipin (PubMed:38322995). May form molecular condensates (non-membrane-bounded organelles) within mitochondria that compartmentalize and promote cardiolipin metabolism (PubMed:38322995). {ECO:0000269|PubMed:21264221, ECO:0000269|PubMed:21264228, ECO:0000269|PubMed:22292033, ECO:0000269|PubMed:38322995}.
uniprot
proteins
mass_dalton
61109
uniprot
proteins
protein_family
MIEAP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
21264221
uniprot
proteins
pubmed
21264228
uniprot
proteins
pubmed
21300779
uniprot
proteins
pubmed
22292033
uniprot
proteins
pubmed
22532927
uniprot
proteins
pubmed
38322995
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21264228, ECO:0000269|PubMed:22292033, ECO:0000269|PubMed:22532927}. Mitochondrion outer membrane {ECO:0000269|PubMed:21264228, ECO:0000269|PubMed:22292033}. Mitochondrion matrix {ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:38322995}. Note=Localizes to the cytosol under normal conditions (PubMed:21264228, PubMed:22532927). Relocalizes to mitochondrion outer membrane following cellular stress. May form molecular condensates in the mitochondrial matrix (PubMed:38322995). Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane (PubMed:22292033). {ECO:0000269|PubMed:21264228, ECO:0000269|PubMed:22292033, ECO:0000269|PubMed:22532927}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:22532927}. Mitochondrion matrix {ECO:0000269|PubMed:22532927}. Note=Appears to predominantly remain in the cytosol following induction of MALM (mitochondrial protein catabolic process). {ECO:0000269|PubMed:22532927}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:22532927}. Mitochondrion matrix {ECO:0000269|PubMed:22532927}. Note=Appears to predominantly localize to the mitochondrial matrix following induction of MALM (mitochondrial protein catabolic process). {ECO:0000269|PubMed:22532927}.
uniprot
proteins