Ifnar2
entrez
15976
canonical
uniprot
O35664
canonical
ensembl
ENSMUSG00000022971
resolver
ensp
ENSMUSP00000023693
resolver
ensp
ENSMUSP00000086443
resolver
ensp
ENSMUSP00000113358
resolver
ensp
ENSMUSP00000252052
resolver
genesymbol
Ifnar2
resolver
uniprot
O35238
resolver
uniprot
O35663
resolver
uniprot
O35983
resolver
uniprot
Q923Z5
resolver
uniprot
Q9D1R7
resolver
uniprot_entry
INAR2_MOUSE
resolver
uniprot_entry
Q9D1R7_MOUSE
resolver
uniprot_sec
O35238
resolver
uniprot_sec
O35663
resolver
uniprot_sec
O35983
resolver
uniprot_sec
Q923Z5
resolver
amino_acid_sequence
MRSRCTVSAVGLLSLCLVVSASLETITPSAFDGYPDEPCTINITIRNSRLILSWELENKSGPPANYTLWYTVMSKDENLTKVKNCSDTTKSSCDVTDKWLEGMESYVVAIVIVHRGDLTVCRCSDYIVPANAPLEPPEFEIVGFTDHINVTMEFPPVTSKIIQEKMKTTPFVIKEQIGDSVRKKHEPKVNNVTGNFTFVLRDLLPKTNYCVSLYFDDDPAIKSPLKCIVLQPGQESGLSESAIVGITTSCLVVMVFVSTIVMLKRIGYICLKDNLPNVLNFRHFLTWIIPERSPSEAIDRLEIIPTNKKKRLWNYDYEDGSDSDEEVPTASVTGYTMHGLTGKPLQQTSDTSASPEDPLHEEDSGAEESDEAGAGAGAEPELPTEAGAGPSEDPTGPYERRKSVLEDSFPREDNSSMDEPGDNIIFNVNLNSVFLRVLHDEDASETLSLEEDTILLDEGPQRTESDLRIAGGDRTQPPLPSLPSQDLWTEDGSSEKSDTSDSDADVGDGYIMR
uniprot
proteins
function
FUNCTION: Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. {ECO:0000250|UniProtKB:P48551}.; FUNCTION: [Isoform 2]: May be potent inhibitors of type I IFN receptor activity. {ECO:0000305|PubMed:9295335, ECO:0000305|PubMed:9322767}.; FUNCTION: [Isoform 3]: May be potent inhibitors of type I IFN receptor activity. {ECO:0000305|PubMed:9295335, ECO:0000305|PubMed:9322767}.
uniprot
proteins
mass_dalton
56578
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-335 or Tyr-510 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types (By similarity). {ECO:0000250|UniProtKB:P48551}.
uniprot
proteins
protein_family
Type II cytokine receptor family
uniprot
proteins
pubmed
11939908
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16944957
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9295335
uniprot
proteins
pubmed
9322767
uniprot
proteins
sequence_length
513
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305|PubMed:9295335, ECO:0000305|PubMed:9322767}; Single-pass type I membrane protein {ECO:0000305|PubMed:9322767}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305|PubMed:9322767}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305|PubMed:9295335, ECO:0000305|PubMed:9322767}.
uniprot
proteins
transmembrane_region
TRANSMEM 243..263; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins