COMMD7
entrez
149951
canonical
uniprot
Q86VX2
canonical
ensembl
ENSG00000149600
resolver
ensp
ENSP00000278980
resolver
ensp
ENSP00000395339
resolver
ensp
ENSP00000525773
resolver
ensp
ENSP00000525775
resolver
ensp
ENSP00000658943
resolver
ensp
ENSP00000695409
resolver
genesymbol
COMMD7
resolver
genesymbol_syn
C20orf92
resolver
hgnc
HGNC:16223
resolver
uniprot
A2BHJ2
resolver
uniprot
B3KTZ2
resolver
uniprot
Q5JYB0
resolver
uniprot
Q96SI7
resolver
uniprot
Q9BW53
resolver
uniprot_entry
COMD7_HUMAN
resolver
uniprot_sec
A2BHJ2
resolver
uniprot_sec
B3KTZ2
resolver
uniprot_sec
Q5JYB0
resolver
uniprot_sec
Q96SI7
resolver
uniprot_sec
Q9BW53
resolver
amino_acid_sequence
MGRLHCTEDPVPEAVGGDMQQLNQLGAQQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFITLGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELTLPQFYSFLHEMERVRTSMECFC
uniprot
proteins
function
FUNCTION: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966). {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129, ECO:0000305|PubMed:21778237}.
uniprot
proteins
mass_dalton
22540
uniprot
proteins
protein_family
COMM domain-containing protein 7 family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15799966
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21778237
uniprot
proteins
pubmed
23563313
uniprot
proteins
pubmed
23637203
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25355947
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
37172566
uniprot
proteins
pubmed
38459129
uniprot
proteins
pubmed
38504028
uniprot
proteins
sequence_length
200
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:21778237}.
uniprot
proteins