Mapt
entrez
17762
canonical
uniprot
P10637
canonical
ensembl
ENSMUSG00000018411
resolver
ensp
ENSMUSP00000097919
resolver
ensp
ENSMUSP00000102601
resolver
ensp
ENSMUSP00000102602
resolver
ensp
ENSMUSP00000102605
resolver
ensp
ENSMUSP00000102606
resolver
ensp
ENSMUSP00000244213
resolver
ensp
ENSMUSP00000244214
resolver
ensp
ENSMUSP00000244215
resolver
ensp
ENSMUSP00000244217
resolver
ensp
ENSMUSP00000244218
resolver
ensp
ENSMUSP00000244219
resolver
ensp
ENSMUSP00000244222
resolver
ensp
ENSMUSP00000244223
resolver
ensp
ENSMUSP00000244224
resolver
ensp
ENSMUSP00000244227
resolver
ensp
ENSMUSP00000244228
resolver
ensp
ENSMUSP00000244232
resolver
ensp
ENSMUSP00000244234
resolver
ensp
ENSMUSP00000244238
resolver
ensp
ENSMUSP00000244241
resolver
ensp
ENSMUSP00000244244
resolver
ensp
ENSMUSP00000244245
resolver
ensp
ENSMUSP00000244252
resolver
ensp
ENSMUSP00000244256
resolver
ensp
ENSMUSP00000244257
resolver
ensp
ENSMUSP00000244268
resolver
ensp
ENSMUSP00000244269
resolver
ensp
ENSMUSP00000356982
resolver
ensp
ENSMUSP00000356983
resolver
ensp
ENSMUSP00000356985
resolver
enst
ENSMUST00000106988
resolver
enst
ENSMUST00000106989
resolver
enst
ENSMUST00000106993
resolver
genesymbol
Mapt
resolver
genesymbol_syn
Mtapt
resolver
genesymbol_syn
Tau
resolver
uniprot
A0A0A0MQC7
resolver
uniprot
A2A5Y6
resolver
uniprot
A2A5Y9
resolver
uniprot
B1AQW2
resolver
uniprot
P10638
resolver
uniprot
Q3UH19
resolver
uniprot
Q547J4
resolver
uniprot
Q60684
resolver
uniprot
Q60685
resolver
uniprot
Q60686
resolver
uniprot
Q62286
resolver
uniprot
Q8C5K4
resolver
uniprot
Q91WK4
resolver
uniprot_entry
A0A0A0MQC7_MOUSE
resolver
uniprot_entry
A2A5Y6_MOUSE
resolver
uniprot_entry
B1AQW2_MOUSE
resolver
uniprot_entry
Q3UH19_MOUSE
resolver
uniprot_entry
Q547J4_MOUSE
resolver
uniprot_entry
Q8C5K4_MOUSE
resolver
uniprot_entry
TAU_MOUSE
resolver
uniprot_sec
A2A5Y9
resolver
uniprot_sec
P10638
resolver
uniprot_sec
Q60684
resolver
uniprot_sec
Q60685
resolver
uniprot_sec
Q60686
resolver
uniprot_sec
Q62286
resolver
uniprot_sec
Q91WK4
resolver
amino_acid_sequence
MADPRQEFDTMEDHAGDYTLLQDQEGDMDHGLKESPPQPPADDGAEEPGSETSDAKSTPTAEDVTAPLVDERAPDKQAAAQPHTEIPEGITAEEAGIGDTPNQEDQAAGHVTQGRREGQAPDLGTSDWTRQQVSSMSGAPLLPQGLREATCQPSGTRPEDIEKSHPASELLRRGPPQKEGWGQDRLGSEEEVDEDLTVDESSQDSPPSQASLTPGRAAPQAGSGSVCGETASVPGLPTEGSVPLPADFFSKVSAETQASQPEGPGTGPMEEGHEAAPEFTFHVEIKASTPKEQDLEGATVVGVPGEEQKAQTQGPSVGKGTKEASLQEPPGKQPAAGLPGRPVSRVPQLKARVASKDRTGNDEKKAKTSTPSCAKAPSHRPCLSPTRPTLGSSDPLIKPSSPAVSPEPATSPKHVSSVTPRNGSPGTKQMKLKGADGKTGAKIATPRGAASPAQKGTSNATRIPAKTTPSPKTPPGSGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
uniprot
proteins
disease_involvement
DISEASE: Note=May be involved in the pathogenesis of cytoplasmic inclusions (as Mallory bodies) in livers of mice chronically intoxicated with Griseofulvin or DDC (3,5-diethoxycarbonyl-2,4-dihydrocollidine), a model for human alcoholic hepatitis. Alteration of Tau (abnormal phosphorylation and cross-linking) could contribute to Mallory bodies formation and disturbance of microtubule function in alcoholic liver disease.
uniprot
proteins
function
FUNCTION: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
uniprot
proteins
mass_dalton
76243
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated. Requires functional TRAF6 and may provoke SQSTM1-dependent degradation by the proteasome (By similarity). {ECO:0000250}.; PTM: Phosphorylation at various serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK1, CDK1, CDK5, GSK3, MAPK) (a few sites per protein in interphase, more in mitosis), and at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1, MARK2, MARK3, MARK4), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylated by PHK. Dephosphorylation at several serine and threonine residues by the serine/threonine phosphatase PPP5C. Phosphorylation at Ser-554 by BRSK1 and BRSK2 in neurons affects ability to bind microtubules and plays a role in neuron polarization. Phosphorylation at Ser-188 by SGK1 mediates microtubule depolymerization and neurite formation in hippocampal neurons (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P10636}.
uniprot
proteins
pubmed
1374898
uniprot
proteins
pubmed
14999081
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15705853
uniprot
proteins
pubmed
15953362
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17482548
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26192747
uniprot
proteins
pubmed
3122323
uniprot
proteins
pubmed
7877441
uniprot
proteins
pubmed
7927211
uniprot
proteins
pubmed
8402267
uniprot
proteins
sequence_length
733
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P10636}. Cell membrane {ECO:0000250|UniProtKB:P10636}; Peripheral membrane protein {ECO:0000250|UniProtKB:P10636}; Cytoplasmic side {ECO:0000250|UniProtKB:P10636}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P10636}. Cell projection, axon {ECO:0000250|UniProtKB:P10636}. Cell projection, dendrite {ECO:0000250|UniProtKB:P10636}. Secreted {ECO:0000250|UniProtKB:P10636}. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000250|UniProtKB:P10636}.
uniprot
proteins