DCTPP1
entrez
79077
canonical
uniprot
Q9H773
canonical
ensembl
ENSG00000179958
resolver
ensp
ENSP00000322524
resolver
enst
ENST00000319285
resolver
genesymbol
DCTPP1
resolver
genesymbol_syn
XTP3TPA
resolver
hgnc
HGNC:28777
resolver
uniprot_entry
DCTP1_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the reaction end product PPi. Inhibited by dCDP. Inhibited by triptolide. {ECO:0000269|PubMed:24467396}.
uniprot
proteins
amino_acid_sequence
MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLSKMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST
uniprot
proteins
ec_number
3.6.1.12
uniprot
proteins
function
FUNCTION: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:24467396}.
uniprot
proteins
mass_dalton
18681
uniprot
proteins
mutagenesis
MUTAGEN 63; /note="E->Q: Loss of dCTP diphosphatase activity."; /evidence="ECO:0000269|PubMed:24467396
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24467396
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
170
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:24467396}. Nucleus {ECO:0000269|PubMed:24467396}. Cytoplasm, cytosol {ECO:0000269|PubMed:24467396}.
uniprot
proteins