Slc25a15
entrez
306574
canonical
uniprot
A0A0G2K309
canonical
ensembl
ENSRNOG00000011881
resolver
ensembl
ENSRNOG00055007863
resolver
ensembl
ENSRNOG00060028226
resolver
ensembl
ENSRNOG00065008805
resolver
ensp
ENSRNOP00000045952
resolver
ensp
ENSRNOP00000072459
resolver
ensp
ENSRNOP00055010593
resolver
ensp
ENSRNOP00060041033
resolver
ensp
ENSRNOP00065010488
resolver
enst
ENSRNOT00000050637
resolver
enst
ENSRNOT00000078971
resolver
enst
ENSRNOT00055013217
resolver
enst
ENSRNOT00060049159
resolver
enst
ENSRNOT00065014049
resolver
genesymbol
Slc25a15
resolver
uniprot
A0A8L2UQI9
resolver
uniprot
Q7TPA1
resolver
uniprot_entry
A0A8L2UQI9_RAT
resolver
uniprot_entry
ORNT1_RAT
resolver
uniprot_entry
Q7TPA1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by pyridoxal 5'-phosphate as well as by mercurials (mersalyl, p-chloromercuribenzene sulfonate, and mercuric chloride), N-ethylmaleimide and spermine. {ECO:0000250|UniProtKB:Q9Y619}.
uniprot
proteins
amino_acid_sequence
MKSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLRTYSQVGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVVGLDRQAKLSDLQNAAAGSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAASQNTVWSVVKEIFRKDGPLGFYHGLSSTLLREVPGYFFFFGGYELSRSFFASGRSKDELGPIPLMLSGGFGGICLWLAVYPVDCIKSRIQVLSMTGKQTGLIRTFLSIVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLMMSQLEAC
uniprot
proteins
function
FUNCTION: Mitochondrial ornithine-citrulline antiporter. Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle (PubMed:10417335, PubMed:9359400). Lysine and arginine are also transported by the antiport mechanism (By similarity). In addition, catalyzes an electroneutral exchange of ornithine or lysine for H(+), a reaction driven by the pH gradient across the inner membrane (PubMed:10417335). {ECO:0000250|UniProtKB:Q9Y619, ECO:0000269|PubMed:10417335, ECO:0000269|PubMed:9359400}.
uniprot
proteins
mass_dalton
32797
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
10417335
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
9359400
uniprot
proteins
sequence_length
301
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q12375}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:15057822}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 68..88; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 237..257; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins