Slc29a1
entrez
63959
canonical
uniprot
Q9JIM1
canonical
ensembl
ENSMUSG00000023942
resolver
ensp
ENSMUSP00000063096
resolver
ensp
ENSMUSP00000063757
resolver
ensp
ENSMUSP00000094923
resolver
ensp
ENSMUSP00000126703
resolver
ensp
ENSMUSP00000129242
resolver
ensp
ENSMUSP00000131976
resolver
ensp
ENSMUSP00000195544
resolver
ensp
ENSMUSP00000195546
resolver
ensp
ENSMUSP00000195552
resolver
ensp
ENSMUSP00000195557
resolver
ensp
ENSMUSP00000195558
resolver
ensp
ENSMUSP00000195561
resolver
ensp
ENSMUSP00000195570
resolver
ensp
ENSMUSP00000195603
resolver
ensp
ENSMUSP00000195606
resolver
ensp
ENSMUSP00000195609
resolver
ensp
ENSMUSP00000195610
resolver
genesymbol
Slc29a1
resolver
genesymbol_syn
Ent1
resolver
uniprot
Q3TCZ2
resolver
uniprot
Q99K84
resolver
uniprot
Q9DBT8
resolver
uniprot
Q9JHF0
resolver
uniprot_entry
Q3TCZ2_MOUSE
resolver
uniprot_entry
S29A1_MOUSE
resolver
uniprot_sec
Q99K84
resolver
uniprot_sec
Q9DBT8
resolver
uniprot_sec
Q9JHF0
resolver
activity_regulation
ACTIVITY REGULATION: Transporter activity is sensitive to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR). {ECO:0000269|PubMed:11085929, ECO:0000269|PubMed:23639800}.
uniprot
proteins
amino_acid_sequence
MTTSHQPQDRYKAVWLIFFVLGLGTLLPWNFFMTATKYFTNRLDVSQNVSSDTDQSCESTKALADPTVALPARSSLSAIFNNVMTLCAMLPLLVFTCLNSFLHQRISQSVRILGSLLAILLVFLVTAALVKVEMDALIFFVITMIKIVLINSFGAILQASLFGLAGVLPANYTAPIMSGQGLAGFFTSVAMICAIASGSELSESAFGYFITACAVVILAILCYLALPRTEFYRHYLQLNLAGPAEQETKLDLISKGEEPKGRREESGVPGPNSPPTNRNQSIKAILKSICVPALSVCFIFTVTIGLFPAVTAEVESSIAGTSPWKSYFIPVACFLNFNVFDWLGRSLTAVCMWPGQDSRWLPVLVASRIVFIPLLMLCNVKARHCGAQRHHFVFKHDAWFIAFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGNIMSFFLCLGLALGAVLSFLLRALV
uniprot
proteins
function
FUNCTION: Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:11085929, PubMed:35790189). Functions as a Na(+)-independent transporter (By similarity). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:11085929, PubMed:23639800, PubMed:35790189). Also transports purine (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (By similarity). Also mediates the uptake of nicotinamide; contributes to maintaining nicotinamide homeostasis but also regulated nicotinamide biological roles (By similarity). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189). {ECO:0000250|UniProtKB:O54698, ECO:0000250|UniProtKB:Q99808, ECO:0000269|PubMed:11085929, ECO:0000269|PubMed:35790189}.
uniprot
proteins
mass_dalton
50192
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:19349973}.
uniprot
proteins
protein_family
SLC29A/ENT transporter (TC 2.A.57) family
uniprot
proteins
pubmed
11027664
uniprot
proteins
pubmed
11085929
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23639800
uniprot
proteins
pubmed
35790189
uniprot
proteins
sequence_length
460
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:Q99808}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:Q99808}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q99808}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..36; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 80..103; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 109..131; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 141..163; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 173..194; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 203..224; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 289..312; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 329..350; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 359..377; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 398..420; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 435..454; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q99808
uniprot
proteins