TAB3
entrez
257397
canonical
uniprot
Q8N5C8
canonical
ensembl
ENSG00000157625
resolver
ensp
ENSP00000288422
resolver
ensp
ENSP00000433193
resolver
ensp
ENSP00000537662
resolver
ensp
ENSP00000537663
resolver
genesymbol
TAB3
resolver
genesymbol_syn
MAP3K7IP3
resolver
hgnc
HGNC:30681
resolver
uniprot
A6NDD9
resolver
uniprot
Q6VQR0
resolver
uniprot_entry
TAB3_HUMAN
resolver
uniprot_sec
A6NDD9
resolver
uniprot_sec
Q6VQR0
resolver
amino_acid_sequence
MAQSSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQESSKYLYMEYHSPDDNRMNRNRLLHINLGIHSPSSYHPGDGAQLNGGRTLVHSSSDGHIDPQHAAGKQLICLVQEPHSAPAVVAATPNYNPFFMNEQNRSAATPPSQPPQQPSSMQTGMNPSAMQGPSPPPPPPSYMHIPRYSTNPITVTVSQNLPSGQTVPRALQILPQIPSNLYGSPGSIYIRQTSQSSSGRQTPQSTPWQSSPQGPVPHYSQRPLPVYPHQQNYQPSQYSPKQQQIPQSAYHSPPPSQCPSPFSSPQHQVQPSQLGHIFMPPSPSTTPPHPYQQGPPSYQKQGSHSVAYLPYTASSLSKGSMKKIEITVEPSQRPGTAINRSPSPISNQPSPRNQHSLYTATTPPSSSPSRGISSQPKPPFSVNPVYITYTQPTGPSCTPSPSPRVIPNPTTVFKITVGRATTENLLNLVDQEERSAAPEPIQPISVIPGSGGEKGSHKYQRSSSSGSDDYAYTQALLLHQRARMERLAKQLKLEKEELERLKSEVNGMEHDLMQRRLRRVSCTTAIPTPEEMTRLRSMNRQLQINVDCTLKEVDLLQSRGNFDPKAMNNFYDNIEPGPVVPPKPSKKDSSDPCTIERKARRISVTSKVQADIHDTQAAAADEHRTGSTQSPRTQPRDEDYEGAPWNCDSCTFLNHPALNRCEQCEMPRYT
uniprot
proteins
function
FUNCTION: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes 'Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}.
uniprot
proteins
mass_dalton
78653
uniprot
proteins
mutagenesis
MUTAGEN 649; /note="K->R: Almost complete loss of AMFR-induced 'Lys-27'-linked ubiquitination."; /evidence="ECO:0000269|PubMed:36593296"; MUTAGEN 689; /note="C->S: Disrupted zinc-finger; abolished methylation at C-692."; /evidence="ECO:0000269|PubMed:22158122"; MUTAGEN 692; /note="C->L,M: Abolished Cys methylation and ability to bind 'Lys-63'-linked ubiquitin."; /evidence="ECO:0000269|PubMed:22158122"; MUTAGEN 703; /note="C->S: Disrupted zinc-finger; abolished methylation at C-692."; /evidence="ECO:0000269|PubMed:22158122"; MUTAGEN 706; /note="C->S: Disrupted zinc-finger; abolished methylation at C-692."; /evidence="ECO:0000269|PubMed:22158122
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; following IL1 stimulation or TRAF6 overexpression (PubMed:14633987). Ubiquitinated by AMFR via 'Lys-27'-linked polyubiquitination; leading to TAK1/MAP3K7 activation (PubMed:36593296). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:36593296}.; PTM: Degraded in a lysosome-dependent manner following interaction with TRIM38. {ECO:0000269|PubMed:24434549}.; PTM: Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment. {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14670075, ECO:0000269|PubMed:18021073}.; PTM: (Microbial infection) Methylated at Cys-692 by enteropathogenic E.coli protein NleE or S.flexneri protein OspZ: methylation disrupts zinc-binding and ability to bind 'Lys-63'-linked ubiquitin, leading to NF-kappa-B inactivation. {ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:27445336}.
uniprot
proteins
pubmed
14633987
uniprot
proteins
pubmed
14670075
uniprot
proteins
pubmed
14766965
uniprot
proteins
pubmed
15327770
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17449468
uniprot
proteins
pubmed
18021073
uniprot
proteins
pubmed
18079694
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19521662
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21512573
uniprot
proteins
pubmed
22158122
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24434549
uniprot
proteins
pubmed
25642820
uniprot
proteins
pubmed
27445336
uniprot
proteins
pubmed
33431678
uniprot
proteins
pubmed
36593296
uniprot
proteins
sequence_length
712
uniprot
proteins