Gspt2
entrez
14853
canonical
uniprot
Q149F3
canonical
ensembl
ENSMUSG00000071723
resolver
ensp
ENSMUSP00000109523
resolver
enst
ENSMUST00000096368
resolver
genesymbol
Gspt2
resolver
genesymbol_syn
Erf3b
resolver
uniprot
O88180
resolver
uniprot
Q9CY91
resolver
uniprot_entry
ERF3B_MOUSE
resolver
uniprot_sec
O88180
resolver
uniprot_sec
Q9CY91
resolver
amino_acid_sequence
MDLGSSSDSAPDCWDQVDMEAPGSAPSGDGIAPAAMAAAEAAEAEAQRKHLSLAFSSQLNIHAKPFVPSVSAAEFVPSFLPGSAQPPAPTASSCDETCIGGAGEPEGKRMEWGAPVEPSKDGPLVSWEGSSSVVTMELSEPVVENGEVEMALEESWELKEVSEAKPEASLGDAGPPEESVKEVMEEKEEVRKSKSVSIPSGAPKKEHVNVVFIGHVDAGKSTIGGQIMFLTGMVDRRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKYLIVLINKMDDPTVDWSSERYEECKEKLVPFLKKVGFSPKKDIHFMPCSGLTGANIKEQSDFCPWYTGLPFIPYLDSLPNFNRSIDGPIRLPIVDKYKDMGTVVLGKLESGSIFKGQQLVMMPNKHSVEVLGIVSDDAETDFVAPGENLKIRLKGIEEEEILPGFILCEPSNLCHSGRTFDVQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALISLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:12354098). GSPT2/ERF3B mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (By similarity). GTP hydrolysis by GSPT2/ERF3B induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). {ECO:0000250|UniProtKB:Q8IYD1, ECO:0000269|PubMed:12354098}.
uniprot
proteins
mass_dalton
69147
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
ERF3 subfamily
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
12354098
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15987998
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9712840
uniprot
proteins
sequence_length
632
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins