IL7
entrez
3574
canonical
uniprot
P13232
canonical
ensembl
ENSG00000104432
resolver
ensp
ENSP00000263851
resolver
ensp
ENSP00000368408
resolver
ensp
ENSP00000427750
resolver
ensp
ENSP00000438922
resolver
enst
ENST00000379113
resolver
enst
ENST00000541183
resolver
genesymbol
IL7
resolver
hgnc
HGNC:6023
resolver
uniprot
A0A0A0MTG5
resolver
uniprot
A0N0L3
resolver
uniprot
A8K673
resolver
uniprot
F6U4X5
resolver
uniprot
Q5FBX5
resolver
uniprot
Q5FBY5
resolver
uniprot
Q5FBY9
resolver
uniprot_entry
A0A0A0MTG5_HUMAN
resolver
uniprot_entry
A8K673_HUMAN
resolver
uniprot_entry
F6U4X5_HUMAN
resolver
uniprot_entry
IL7_HUMAN
resolver
uniprot_entry
Q5FBX5_HUMAN
resolver
uniprot_sec
A0N0L3
resolver
uniprot_sec
Q5FBY5
resolver
uniprot_sec
Q5FBY9
resolver
amino_acid_sequence
MFHVSFRYIFGLPPLILVLLPVASSDCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQVKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 130 with HPV-related verrucosis (IMD130) [MIM:618309]: An autosomal recessive immunologic disorder characterized by susceptibility to human papillomavirus (HPV) infections that lead to the development of warts and verrucous or plaque-like skin lesions. There is an increased risk of skin malignancy. Some patients may also suffer from mycobacterial, herpes simplex virus (HSV), or fungal infections. Immunologic workup shows T-cell lymphopenia, particularly affecting CD4+ T cells. {ECO:0000269|PubMed:25981006}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis (PubMed:25870237, PubMed:7527823). Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG (PubMed:8128231). Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5 (PubMed:18523275, PubMed:20974963). {ECO:0000269|PubMed:18523275, ECO:0000269|PubMed:20974963, ECO:0000269|PubMed:25870237, ECO:0000269|PubMed:7527823, ECO:0000269|PubMed:8128231}.
uniprot
proteins
mass_dalton
20187
uniprot
proteins
protein_family
IL-7/IL-9 family
uniprot
proteins
pubmed
10850801
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
18523275
uniprot
proteins
pubmed
19141282
uniprot
proteins
pubmed
20974963
uniprot
proteins
pubmed
2329282
uniprot
proteins
pubmed
25870237
uniprot
proteins
pubmed
25981006
uniprot
proteins
pubmed
2643102
uniprot
proteins
pubmed
7527823
uniprot
proteins
pubmed
8128231
uniprot
proteins
pubmed
8862549
uniprot
proteins
pubmed
9407080
uniprot
proteins
sequence_length
177
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25870237}.
uniprot
proteins