Nps
entrez
100360071
canonical
uniprot
P0C0P7
canonical
ensembl
ENSRNOG00000036653
resolver
ensembl
ENSRNOG00060025820
resolver
ensp
ENSRNOP00000051780
resolver
ensp
ENSRNOP00060037022
resolver
enst
ENSRNOT00000054896
resolver
enst
ENSRNOT00060044670
resolver
genesymbol
Nps
resolver
uniprot_entry
NPS_RAT
resolver
amino_acid_sequence
MIGSLKLNLILALSLSVVHVIWSYPVLSSKVPGKPDYFLILLSTCPARLEGSDGLAFLKPILEKTSMKRSFRNGVGSGVKKTSFRRAKQ
uniprot
proteins
function
FUNCTION: Ligand for NPSR1 (PubMed:15312648). Binds to its receptor with nanomolar affinity and initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway (PubMed:15312648). This results in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels (PubMed:15312648). In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction (By similarity). Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade (By similarity). May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. {ECO:0000250|UniProtKB:P0C0P6, ECO:0000269|PubMed:15312648, ECO:0000269|PubMed:15919054}.
uniprot
proteins
mass_dalton
9763
uniprot
proteins
pubmed
15312648
uniprot
proteins
pubmed
15919054
uniprot
proteins
pubmed
21861171
uniprot
proteins
sequence_length
89
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21861171}.
uniprot
proteins