Syncrip
entrez
56403
canonical
uniprot
Q7TMK9
canonical
ensembl
ENSMUSG00000032423
resolver
ensp
ENSMUSP00000063744
resolver
ensp
ENSMUSP00000133649
resolver
ensp
ENSMUSP00000134071
resolver
ensp
ENSMUSP00000134342
resolver
enst
ENSMUST00000174282
resolver
enst
ENSMUST00000174391
resolver
genesymbol
Syncrip
resolver
genesymbol_syn
Hnrpq
resolver
genesymbol_syn
Nsap1
resolver
genesymbol_syn
Nsap1l
resolver
uniprot
A0A0R4J259
resolver
uniprot
G3UZ48
resolver
uniprot
O88991
resolver
uniprot
Q2YDV8
resolver
uniprot
Q3TRV3
resolver
uniprot
Q68ED6
resolver
uniprot
Q80YV6
resolver
uniprot
Q8BGP1
resolver
uniprot
Q8C5K6
resolver
uniprot
Q8CGC2
resolver
uniprot
Q91ZR0
resolver
uniprot
Q99KU9
resolver
uniprot
Q9QYF4
resolver
uniprot_entry
A0A0R4J259_MOUSE
resolver
uniprot_entry
G3UZ48_MOUSE
resolver
uniprot_entry
HNRPQ_MOUSE
resolver
uniprot_entry
Q3TRV3_MOUSE
resolver
uniprot_sec
O88991
resolver
uniprot_sec
Q2YDV8
resolver
uniprot_sec
Q68ED6
resolver
uniprot_sec
Q80YV6
resolver
uniprot_sec
Q8BGP1
resolver
uniprot_sec
Q8C5K6
resolver
uniprot_sec
Q8CGC2
resolver
uniprot_sec
Q91ZR0
resolver
uniprot_sec
Q99KU9
resolver
uniprot_sec
Q9QYF4
resolver
amino_acid_sequence
MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKSFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPPRGRAGYSQRGGPGSARGVRGARGGAQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDTKRRQTNNQNWGSQPIAQQPLQGGDHSGNYGYKSENQEFYQDTFGQQWK
uniprot
proteins
function
FUNCTION: Heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1 and isoform 2 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences (By similarity). Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself (By similarity). May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 2 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. {ECO:0000250}.
uniprot
proteins
mass_dalton
69633
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine. The membrane-bound form found in microsomes is phosphorylated in vitro by insulin receptor tyrosine kinase (INSR). Phosphorylation is inhibited upon binding to RNA, whereas the cytoplasmic form is poorly phosphorylated. {ECO:0000269|PubMed:11994298}.
uniprot
proteins
pubmed
10734137
uniprot
proteins
pubmed
11773003
uniprot
proteins
pubmed
11994298
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19470752
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9847309
uniprot
proteins
sequence_length
623
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10734137, ECO:0000269|PubMed:11994298}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:O43390}. Microsome {ECO:0000269|PubMed:11994298}. Cytoplasm {ECO:0000269|PubMed:10734137}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). Isoforms 1 and 2 are expressed predominantly in the nucleoplasm. According to PubMed:10734137, isoform 2 is predominantly found in cytoplasm. The tyrosine phosphorylated form bound to RNA is found in microsomes. {ECO:0000250|UniProtKB:O43390, ECO:0000269|PubMed:10734137}.
uniprot
proteins