APOC2
entrez
344
canonical
uniprot
P02655
canonical
ensembl
ENSG00000234906
resolver
ensp
ENSP00000252490
resolver
ensp
ENSP00000466775
resolver
ensp
ENSP00000566606
resolver
ensp
ENSP00000566608
resolver
ensp
ENSP00000566612
resolver
ensp
ENSP00000566613
resolver
ensp
ENSP00000566616
resolver
ensp
ENSP00000566619
resolver
ensp
ENSP00000638287
resolver
enst
ENST00000252490
resolver
enst
ENST00000590360
resolver
enst
ENST00000896547
resolver
enst
ENST00000896549
resolver
enst
ENST00000896553
resolver
enst
ENST00000896554
resolver
enst
ENST00000896557
resolver
enst
ENST00000896560
resolver
enst
ENST00000968228
resolver
genesymbol
APOC2
resolver
genesymbol_syn
APC2
resolver
hgnc
HGNC:609
resolver
uniprot
A0A024R0T9
resolver
uniprot
C0JYY4
resolver
uniprot
Q9BS39
resolver
uniprot
Q9UDE3
resolver
uniprot
Q9UNK3
resolver
uniprot_entry
A0A024R0T9_HUMAN
resolver
uniprot_entry
APOC2_HUMAN
resolver
uniprot_sec
C0JYY4
resolver
uniprot_sec
Q9BS39
resolver
uniprot_sec
Q9UDE3
resolver
uniprot_sec
Q9UNK3
resolver
amino_acid_sequence
MGTRLLPALFLVLLVLGFEVQGTQQPQQDEMPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE
uniprot
proteins
disease_involvement
DISEASE: Hyperlipoproteinemia 1B (HLPP1B) [MIM:207750]: Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. {ECO:0000269|PubMed:8323539}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL. {ECO:0000269|PubMed:2209608, ECO:0000303|PubMed:22304839}.
uniprot
proteins
mass_dalton
11284
uniprot
proteins
post_translational_modification
PTM: Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing. {ECO:0000269|PubMed:3525527}.; PTM: Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma. {ECO:0000269|PubMed:3525527}.
uniprot
proteins
protein_family
Apolipoprotein C2 family
uniprot
proteins
pubmed
10391210
uniprot
proteins
pubmed
11310852
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1555583
uniprot
proteins
pubmed
1782747
uniprot
proteins
pubmed
194244
uniprot
proteins
pubmed
2209608
uniprot
proteins
pubmed
22304839
uniprot
proteins
pubmed
23234360
uniprot
proteins
pubmed
2415514
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
3014272
uniprot
proteins
pubmed
3030808
uniprot
proteins
pubmed
3525527
uniprot
proteins
pubmed
3558370
uniprot
proteins
pubmed
3944271
uniprot
proteins
pubmed
6328445
uniprot
proteins
pubmed
6546757
uniprot
proteins
pubmed
6593704
uniprot
proteins
pubmed
6706938
uniprot
proteins
pubmed
6772077
uniprot
proteins
pubmed
7923858
uniprot
proteins
pubmed
8112221
uniprot
proteins
pubmed
8323539
uniprot
proteins
pubmed
8490626
uniprot
proteins
sequence_length
101
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3525527}.
uniprot
proteins