Tgfbrap1
entrez
73122
canonical
uniprot
Q3UR70
canonical
ensembl
ENSMUSG00000070939
resolver
ensp
ENSMUSP00000092624
resolver
ensp
ENSMUSP00000140132
resolver
ensp
ENSMUSP00000223528
resolver
ensp
ENSMUSP00000223532
resolver
ensp
ENSMUSP00000223541
resolver
genesymbol
Tgfbrap1
resolver
uniprot
Q8BKN4
resolver
uniprot_entry
TGFA1_MOUSE
resolver
uniprot_sec
Q8BKN4
resolver
amino_acid_sequence
MMNIKAFTLVSAVERELLMGDRDHISIECVECCGRNLYVGTNDCFIYHFLLEEKAMPTGTATFVATKQLHRHLGFKKPVNELCAASALNRLLVLCDNSITLVNMLNLEPVPSGARIKGATTFAVNESPVNGDPFCVEVCIISVKRRTVQMFLVYEDRVQIVKEVSTPEQPLAVAVDGYFLCLALTTQYIILNYSTGLSQDLFPYCSEEKPPIVKRIGRQEFLLAGPGGLGMFATVAGISQRAPVHWSENVIGAAVCFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLPLEKQIQDLLANRRVEEALVLAKGARRNIPKEKFQVMYRRILQQAGFIQFAQLQFLEAKELFRSSQLDVRELISLYPFLLPTSSSFTRSHPPLHEYADLNQLTQGDQEKMAKCKRFLMSYLNEIRSTEVANGYKEDIDTALLKLYAEADHDSLLDLLVTENFCLLTDSAAWLEKHKKYFALGLLYHYNKQDASAVQLWVNIVNGDIQDSTRSDLYEYIVDFLTYCLDQELVWTHADWLLQKSEEIGVQIFTKRPLDEQQQTSFNPDNIISSLKKYPKALVKYLEHLVIDRRLQKEEYHTHLAILYLEEVLRQRVSTGGKDVEATETQAKLRRLLQKSDLYRVHLLKEKVQGAGLPMESAILHGKLGEHEKALHILVHEMGDFSAAEDYCLWSSEGQGAACRQRLFHTLLAMYLRAGPSAQDLTVAAVDLLNHHAREFDVTQVLQLLPDTWSVQLLCPFLMGAMRDSIHARRTTQVALGLAKSENLIYMYDKMKLKGNAVRLSERELCQLCQNPFGEPVFVRYPNGGLVHTHCAASRHTAPSSPSPGTRT
uniprot
proteins
function
FUNCTION: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 (By similarity). {ECO:0000250}.; FUNCTION: Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo (By similarity). {ECO:0000250|UniProtKB:Q8WUH2}.
uniprot
proteins
mass_dalton
97303
uniprot
proteins
protein_family
TRAP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20961651
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25266290
uniprot
proteins
sequence_length
860
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Early endosome {ECO:0000250|UniProtKB:Q8WUH2}. Note=Colocalizes with TGF-beta receptors in the absence of signaling. {ECO:0000250|UniProtKB:Q8WUH2}.
uniprot
proteins