Gdf6
entrez
252834
canonical
uniprot
Q6HA10
canonical
ensembl
ENSRNOG00000067800
resolver
ensembl
ENSRNOG00055020007
resolver
ensembl
ENSRNOG00065015165
resolver
ensp
ENSRNOP00000082414
resolver
ensp
ENSRNOP00055027705
resolver
ensp
ENSRNOP00065019648
resolver
enst
ENSRNOT00000101359
resolver
enst
ENSRNOT00055034153
resolver
enst
ENSRNOT00065025106
resolver
genesymbol
Gdf6
resolver
genesymbol_syn
Bmp13
resolver
genesymbol_syn
Gdf16
resolver
uniprot
Q8K4X4
resolver
uniprot_entry
GDF6_RAT
resolver
uniprot_sec
Q8K4X4
resolver
amino_acid_sequence
MDTPRVLLWAIFLISFLWDLPGFQQASISSSSSTELDSTKDVENRKGGKMQRTPQESAEGRTPKEHRPRPNELRRRLPGQSLGQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSTLSDKEELVGAELRLYRQAPPTPWGPQTRPLHLQLFPCLSPLLLDSRTLDPQGPTEAGWEVFDVWQVLRPQPWKQLCLELRAVWGELDARDSGARPRGPQQSPPLDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFTEMHEQLGSAEAAGAEGSWPAPSGAPDAGSWLPSPGRRRRRTALSSRHGKRHGKKSRLRCSRKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR
uniprot
proteins
function
FUNCTION: Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures. Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG. Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38. {ECO:0000250|UniProtKB:P43028, ECO:0000250|UniProtKB:Q6KF10}.
uniprot
proteins
mass_dalton
51013
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
sequence_length
452
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6KF10}.
uniprot
proteins