Gabrg2
entrez
14406
canonical
uniprot
P22723
canonical
ensembl
ENSMUSG00000020436
resolver
ensp
ENSMUSP00000063812
resolver
ensp
ENSMUSP00000064739
resolver
genesymbol
Gabrg2
resolver
uniprot
Q91V50
resolver
uniprot
Q91VA8
resolver
uniprot_entry
GBRG2_MOUSE
resolver
uniprot_sec
Q91V50
resolver
uniprot_sec
Q91VA8
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by benzodiazepines (By similarity). Activated by pentobarbital (By similarity). Inhibited by the antagonist bicuculline (By similarity). Inhibited by zinc ions (By similarity). Potentiated by histamine (PubMed:18281286). {ECO:0000250|UniProtKB:P18507, ECO:0000250|UniProtKB:P18508, ECO:0000269|PubMed:18281286}.
uniprot
proteins
amino_acid_sequence
MSSPNTWSIGSSVYSPVFSQKMTLWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
uniprot
proteins
function
FUNCTION: Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:18281286, PubMed:27129275). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:27129275). Extrasynaptic gamma-2-containing receptors contribute to the tonic GABAergic inhibition (By similarity). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (PubMed:18281286). {ECO:0000250|UniProtKB:P08219, ECO:0000250|UniProtKB:P18507, ECO:0000250|UniProtKB:P18508, ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:27129275}.
uniprot
proteins
mass_dalton
55099
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:27129275}.; PTM: Palmitoylated by ZDHHC3/GODZ; required for the accumulation of GABA(A) receptors at the postsynaptic membrane of inhibitory GABAergic synapses. {ECO:0000269|PubMed:15207850, ECO:0000269|PubMed:15229235, ECO:0000269|PubMed:17151279}.
uniprot
proteins
protein_family
GABRG2 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
11003197
uniprot
proteins
pubmed
15207850
uniprot
proteins
pubmed
15229235
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17151279
uniprot
proteins
pubmed
18281286
uniprot
proteins
pubmed
1846404
uniprot
proteins
pubmed
25172774
uniprot
proteins
pubmed
27129275
uniprot
proteins
pubmed
28279354
uniprot
proteins
pubmed
28978485
uniprot
proteins
pubmed
29742426
uniprot
proteins
pubmed
31601770
uniprot
proteins
sequence_length
474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:17151279, ECO:0000269|PubMed:18281286}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18507}. Cell membrane {ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:25172774, ECO:0000269|PubMed:28279354}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18507}. Cell projection, dendrite {ECO:0000269|PubMed:25172774}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P18508}.
uniprot
proteins
transmembrane_region
TRANSMEM 275..295; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P18507"; TRANSMEM 302..321; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P18507"; TRANSMEM 334..358; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P18507"; TRANSMEM 451..472; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P18507
uniprot
proteins