Slc4a4
entrez
84484
canonical
uniprot
Q9JI66
canonical
ensembl
ENSRNOG00000003134
resolver
ensp
ENSRNOP00000004391
resolver
ensp
ENSRNOP00000035006
resolver
ensp
ENSRNOP00000092374
resolver
enst
ENSRNOT00000101333
resolver
genesymbol
Slc4a4
resolver
genesymbol_syn
Nbc
resolver
genesymbol_syn
Nbc1
resolver
genesymbol_syn
Nbce1
resolver
genesymbol_syn
Rnbc1
resolver
uniprot
A0A8I6AFE1
resolver
uniprot
O35422
resolver
uniprot
O54815
resolver
uniprot
Q9JJ32
resolver
uniprot
Q9QXH6
resolver
uniprot_entry
A0A8I6AFE1_RAT
resolver
uniprot_entry
S4A4_RAT
resolver
uniprot_sec
O35422
resolver
uniprot_sec
O54815
resolver
uniprot_sec
Q9JJ32
resolver
uniprot_sec
Q9QXH6
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS). {ECO:0000269|PubMed:10837348}.
uniprot
proteins
amino_acid_sequence
MEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKAGHKEKKEKERISENYSDKSDVENADESSSSILKPLISPAAERIRFILGEEDDSPAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREASSLPQLVEMIADHQIETGLLKPDLKDKVTYTLLRKHRHQTKKSNLRSLADIGKTVSSASRMFSNPDNGSPAMTHRNLTSSSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDHSFDYLEFRLWIGLWSAFMCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSDFRVGYNTHFSCACLPPDPVNLSVSNDTTLAPEDLPTVSSTDMYHNATFDWAYLSKKECVKFGGKLVGNNCDFVPDITLMSFILFLGTYTSSMAMKKFKTSRYFPTTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPHRGWFVPPFGGNPWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVVCSFMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTSLQVLCLALLWILKSTVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSLDSDNDDSDCPYSEKVPSIKIPMDITEQQPFLSDNKPLDRERSSTFLERHTSC
uniprot
proteins
function
FUNCTION: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10648705, ECO:0000269|PubMed:10837348, ECO:0000269|PubMed:12604466, ECO:0000269|PubMed:9486238}.
uniprot
proteins
mass_dalton
121343
uniprot
proteins
mutagenesis
MUTAGEN Q9JI66-2:33; /note="N->Q: No effect on N-glycosylation."; /evidence="ECO:0000269|PubMed:12604466"; MUTAGEN Q9JI66-2:199; /note="N->Q: No effect on N-glycosylation."; /evidence="ECO:0000269|PubMed:12604466"; MUTAGEN Q9JI66-2:208; /note="N->Q: No effect on N-glycosylation."; /evidence="ECO:0000269|PubMed:12604466"; MUTAGEN Q9JI66-2:497; /note="N->Q: No effect on N-glycosylation."; /evidence="ECO:0000269|PubMed:12604466"; MUTAGEN Q9JI66-2:592; /note="N->Q: No effect on N-glycosylation. Complete loss of N-glycosylation without effect on transporter basic function; when associated with Q-597 and Q-617."; /evidence="ECO:0000269|PubMed:12604466"; MUTAGEN Q9JI66-2:597; /note="N->Q: Reduces the extent of N-glycosylation. Complete loss of N-glycosylation without effect on transporter basic function; when associated with Q-592 and Q-617."; /evidence="ECO:0000269|PubMed:12604466"; MUTAGEN Q9JI66-2:617; /note="N->Q: Reduces the extent of N-glycosylation. Complete loss of N-glycosylation without effect on transporter basic function; when associated with Q-592 and Q-597."; /evidence="ECO:0000269|PubMed:12604466
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylated in presence of STK39 and dephosphorylated in presence of PP1 phosphatase; phosphorylation seems to inhibit SLC4A4 activity. {ECO:0000250|UniProtKB:O88343, ECO:0000250|UniProtKB:Q9Y6R1}.; PTM: [Isoform 2]: N-glycosylation is not necessary for the transporter basic functions. {ECO:0000269|PubMed:12604466}.
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
10648705
uniprot
proteins
pubmed
10837348
uniprot
proteins
pubmed
11592950
uniprot
proteins
pubmed
11703600
uniprot
proteins
pubmed
12444017
uniprot
proteins
pubmed
12604466
uniprot
proteins
pubmed
15329059
uniprot
proteins
pubmed
15781297
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9486238
uniprot
proteins
pubmed
9841505
uniprot
proteins
sequence_length
1079
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000305|PubMed:10837348}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9Y6R1}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 467..491; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 502..520; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 522..542; /note="Discontinuously helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 551..571; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 586..609; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 693..710; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 726..745; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 780..807; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 820..836; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 838..855; /note="Discontinuously helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 878..894; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 902..918; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1
uniprot
proteins