Coxfa4l2
entrez
407790
canonical
uniprot
Q4FZG9
canonical
ensembl
ENSMUSG00000040280
resolver
ensp
ENSMUSP00000042185
resolver
enst
ENSMUST00000035735
resolver
genesymbol
Coxfa4l2
resolver
genesymbol_syn
Ndufa4l2
resolver
uniprot_entry
CX4L2_MOUSE
resolver
amino_acid_sequence
MAGTSLGTRFYRQIKRHPGLIPMIGFICLGMGSAGLYLLRLALRSPDVCWDRKNNPEPWNRLSPNDQYKFLAVSTDYKKLKKDRPDF
uniprot
proteins
function
FUNCTION: Mitochondrial protein that plays a regulatory role in cellular metabolism, particularly under hypoxic conditions (PubMed:22100406, PubMed:34724256). Down-regulates mitochondrial respiratory chain complex I activity under hypoxia, reduces oxygen consumption and ROS (PubMed:22100406, PubMed:34724256, PubMed:37558878). {ECO:0000269|PubMed:22100406, ECO:0000269|PubMed:34724256, ECO:0000269|PubMed:37558878}.
uniprot
proteins
mass_dalton
10046
uniprot
proteins
protein_family
Complex IV COXFA4 subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22100406
uniprot
proteins
pubmed
34724256
uniprot
proteins
pubmed
37558878
uniprot
proteins
sequence_length
87
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9NRX3}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins