TMEM45B
entrez
120224
canonical
uniprot
Q96B21
canonical
ensembl
ENSG00000151715
resolver
ensp
ENSP00000281441
resolver
ensp
ENSP00000436293
resolver
ensp
ENSP00000557416
resolver
ensp
ENSP00000557417
resolver
ensp
ENSP00000557418
resolver
ensp
ENSP00000557419
resolver
ensp
ENSP00000557420
resolver
ensp
ENSP00000557421
resolver
ensp
ENSP00000557422
resolver
ensp
ENSP00000557423
resolver
ensp
ENSP00000557424
resolver
ensp
ENSP00000557428
resolver
ensp
ENSP00000557429
resolver
ensp
ENSP00000557430
resolver
ensp
ENSP00000557432
resolver
ensp
ENSP00000557433
resolver
ensp
ENSP00000557435
resolver
ensp
ENSP00000614835
resolver
ensp
ENSP00000614836
resolver
ensp
ENSP00000614837
resolver
ensp
ENSP00000614838
resolver
ensp
ENSP00000614839
resolver
ensp
ENSP00000614840
resolver
ensp
ENSP00000614841
resolver
enst
ENST00000281441
resolver
enst
ENST00000524567
resolver
enst
ENST00000887357
resolver
enst
ENST00000887358
resolver
enst
ENST00000887359
resolver
enst
ENST00000887360
resolver
enst
ENST00000887361
resolver
enst
ENST00000887362
resolver
enst
ENST00000887363
resolver
enst
ENST00000887364
resolver
enst
ENST00000887365
resolver
enst
ENST00000887369
resolver
enst
ENST00000887370
resolver
enst
ENST00000887371
resolver
enst
ENST00000887373
resolver
enst
ENST00000887374
resolver
enst
ENST00000887376
resolver
enst
ENST00000944776
resolver
enst
ENST00000944777
resolver
enst
ENST00000944778
resolver
enst
ENST00000944779
resolver
enst
ENST00000944780
resolver
enst
ENST00000944781
resolver
enst
ENST00000944782
resolver
genesymbol
TMEM45B
resolver
hgnc
HGNC:25194
resolver
uniprot
A8K2L8
resolver
uniprot_entry
TM45B_HUMAN
resolver
uniprot_sec
A8K2L8
resolver
amino_acid_sequence
MANFKGHALPGSFFLIIGLCWSVKYPLKYFSHTRKNSPLHYYQRLEIVEAAIRTLFSVTGILAEQFVPDGPHLHLYHENHWIKLMNWQHSTMYLFFAVSGIVDMLTYLVSHVPLGVDRLVMAVAVFMEGFLFYYHVHNRPPLDQHIHSLLLYALFGGCVSISLEVIFRDHIVLELFRTSLIILQGTWFWQIGFVLFPPFGTPEWDQKDDANLMFITMCFCWHYLAALSIVAVNYSLVYCLLTRMKRHGRGEIIGIQKLNSDDTYQTALLSGSDEE
uniprot
proteins
function
FUNCTION: Plays a role in innate immunity (PubMed:35938871). Mechanistically, promotes alphaviruses RNA degradation by interacting with the viral polymerase nsP4 and the mRNA-capping enzyme nsP1 and thereby interfering with the interaction between viral RNA and nsP1 (PubMed:35938871). Essential for inflammation- and tissue injury-induced mechanical pain hypersensitivity (By similarity). {ECO:0000250|UniProtKB:Q8VCZ2, ECO:0000269|PubMed:35938871}.
uniprot
proteins
mass_dalton
31826
uniprot
proteins
protein_family
TMEM45 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
35938871
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:35938871}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:35938871}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:35938871}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 180..200; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 212..232; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins