Gabrr2
entrez
14409
canonical
uniprot
P56476
canonical
ensembl
ENSMUSG00000023267
resolver
ensp
ENSMUSP00000024035
resolver
genesymbol
Gabrr2
resolver
uniprot
Q6PEP0
resolver
uniprot_entry
GBRR2_MOUSE
resolver
uniprot_sec
Q6PEP0
resolver
amino_acid_sequence
MPYLMRLALVLFCLMALVESRKPRRKRWTGLLETSKPSHLYKKNLDVTKMRPGKPRPLLRVEDHDFTMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWRDERLAFPSSSNKSMTFDGRLVKKIWVPDVFFVHSKRSFIHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDHRAVPARVSLGIMTVLTMSTIITGVNASMPRVSYIRAVDIYLWVSFVFVFLSVLEYAAVNYLTTLQEQKERKFREKLPCMCGMLHSRTMMLDGSYSESEANSLAGYPRSHILPEEERPDNIVVHLALNSELTSSRKKGLLKGQMGLYIFQNTHAIDKYSRLIFPAFYIVFNLIYWSVFS
uniprot
proteins
function
FUNCTION: Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (By similarity). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (By similarity). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Rho-2 GABAARs may contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (PubMed:25422464). Rho-2 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (PubMed:16945976). Rho-2 GABAARs expressed in retina may play a role in retinal neurotransmission (By similarity). {ECO:0000250|UniProtKB:P24046, ECO:0000250|UniProtKB:P47742, ECO:0000269|PubMed:16945976, ECO:0000269|PubMed:25422464}.
uniprot
proteins
mass_dalton
54231
uniprot
proteins
protein_family
GABRR2 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16945976
uniprot
proteins
pubmed
25422464
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:16945976}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:25422464}; Multi-pass membrane protein {ECO:0000255}. Note=Located at the plasma membrane of astrocytes, in soma and to some extent in distal processes. {ECO:0000269|PubMed:25422464}.
uniprot
proteins
transmembrane_region
TRANSMEM 261..281; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 294..314; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 326..346; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 444..464; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins