Camsap3
entrez
69697
canonical
uniprot
Q80VC9
canonical
ensembl
ENSMUSG00000044433
resolver
ensp
ENSMUSP00000058958
resolver
ensp
ENSMUSP00000125993
resolver
ensp
ENSMUSP00000146359
resolver
ensp
ENSMUSP00000146565
resolver
ensp
ENSMUSP00000146772
resolver
ensp
ENSMUSP00000146852
resolver
ensp
ENSMUSP00000146896
resolver
ensp
ENSMUSP00000147209
resolver
ensp
ENSMUSP00000253505
resolver
ensp
ENSMUSP00000253506
resolver
ensp
ENSMUSP00000253507
resolver
ensp
ENSMUSP00000253508
resolver
ensp
ENSMUSP00000253510
resolver
ensp
ENSMUSP00000253515
resolver
ensp
ENSMUSP00000344980
resolver
ensp
ENSMUSP00000344983
resolver
genesymbol
Camsap3
resolver
genesymbol_syn
Kiaa1543
resolver
uniprot
E9Q5B0
resolver
uniprot
Q5DTW9
resolver
uniprot
Q8BUZ0
resolver
uniprot
U5LGR7
resolver
uniprot
U5LGS1
resolver
uniprot
U5LGS5
resolver
uniprot
U5LGT0
resolver
uniprot
U5LHT8
resolver
uniprot
U5LHU4
resolver
uniprot
U5LHW1
resolver
uniprot
U5LHW4
resolver
uniprot
U5LHW9
resolver
uniprot
U5LK15
resolver
uniprot
U5LK19
resolver
uniprot
U5LK24
resolver
uniprot
U5LK70
resolver
uniprot
U5LK74
resolver
uniprot
U5LK79
resolver
uniprot_entry
CAMP3_MOUSE
resolver
uniprot_sec
E9Q5B0
resolver
uniprot_sec
Q5DTW9
resolver
uniprot_sec
Q8BUZ0
resolver
uniprot_sec
U5LGR7
resolver
uniprot_sec
U5LGS1
resolver
uniprot_sec
U5LGS5
resolver
uniprot_sec
U5LGT0
resolver
uniprot_sec
U5LHT8
resolver
uniprot_sec
U5LHU4
resolver
uniprot_sec
U5LHW1
resolver
uniprot_sec
U5LHW4
resolver
uniprot_sec
U5LHW9
resolver
uniprot_sec
U5LK15
resolver
uniprot_sec
U5LK19
resolver
uniprot_sec
U5LK24
resolver
uniprot_sec
U5LK70
resolver
uniprot_sec
U5LK74
resolver
uniprot_sec
U5LK79
resolver
amino_acid_sequence
MVEAAPAGSGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPPELWEPFYTDQYAQEHVKPPVTRLLLSAELYCRAWRQALPQLEPSPSPSALLALLARRGTVPSLPEHPVREADLKHQPILMGAHLAVIDALMVAFSFEWTKTLPGPLALSSLEHKLLFWVDTTVRRLQEKTEQEAAQRASPAAPLDGASPAQPSIRYRKDRAIARRAPCFPNVTTLQDLASGAALAATIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLVQDFCASHLPRGCPLSLEDLLYVPPPLKVNLVVLLAEMYMCFEVLKPDFVQAKDLPDGHAVSPRNTETVPSQNNSGSSSPVFNFRHPLLSPGGPQSPLRGSTGSLKSSPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPPRPVSTSSRNSAQPAPESGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGLSKPPLSPYPPEGASKPLSDRLNKAPIYISHPENPSKSSPCSTGEILKPPPPSEGSPKAVASSPAANNSEVKMTSFAERKKQLVKAEAESGLGSPTSTPVAPEALSSEMSELGARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREAAGEAEEEAELGSVPGGERPAGEGQGEPSLRHKSVTFSPDLGPVPPEGLGDYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPPEAPGPAPPPAAWVIPGPATGPKAASPSPARRAPAARRSPGPGPSPTPRSPKHARPAELKLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLSEGTPPEEPTTKPALIEIPLASLGEPAADEEGDGSPPGAEDSLEEEASSEGEPRSGLGFFYKDEDKPEDEMAQKRASLLERQQRRVEEARRRKQWQEAEKEQKREEAARLAQEAPGLAFTTPVVASAAPVATLAPTTRAMAPAEEEVGPRRGDFTRLEYERRAQLKLMDDLDKVLRPRASGTGGPGRGGRRATRPRSGCCDDSALARSPARGLLGSRLSKVYSQSTLSLSTVANEAPNNLGVKRPTSRAPSPSGLMSPSRLPGSRERDWENGSNASSPASVPEYTGPRLYKEPSAKSNKFIIHNALSHCCLAGKVNEPQKNRILEEIEKSKANHFLILFRDSSCQFRALYTLSGETEELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQIPAKTMSMSVDAFTIQGHLWQSKKPTTPKKGGGTPK
uniprot
proteins
function
FUNCTION: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24706919, PubMed:26715742). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24706919). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (By similarity). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (PubMed:28860385). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (By similarity). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (By similarity). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (By similarity). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (By similarity). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (PubMed:32482850). {ECO:0000250|UniProtKB:Q9P1Y5, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:28860385, ECO:0000269|PubMed:32482850}.
uniprot
proteins
mass_dalton
135175
uniprot
proteins
mutagenesis
MUTAGEN 608..612; /note="LEEKR->AAAAA: Retains the ability to interact with microtubules but abolishes the apical localization in epithelial cells."; /evidence="ECO:0000269|PubMed:26715742
uniprot
proteins
protein_family
CAMSAP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23169647
uniprot
proteins
pubmed
24244856
uniprot
proteins
pubmed
24706919
uniprot
proteins
pubmed
26715742
uniprot
proteins
pubmed
27349180
uniprot
proteins
pubmed
28860385
uniprot
proteins
pubmed
30787442
uniprot
proteins
pubmed
32482850
uniprot
proteins
sequence_length
1252
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24244856, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:28860385}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9P1Y5}. Cytoplasm {ECO:0000250|UniProtKB:Q9P1Y5}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:32482850}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:32482850}. Note=Scattered in the cytoplasm, associated with the minus-end of microtubules and also detected at the centrosomes (PubMed:24706919, PubMed:26715742). Decorates the minus-end of microtubules by decreasing the rate of tubulin incorporation and remaining bound (By similarity). Localizes along zonula adherens only at mature cell-cell contacts (By similarity). In early embryos, accumulates at the microtubule bridges that connect pairs of cells: this structure is present in early embryos, which lack centrosomes (PubMed:28860385). This cytokinetic bridge does not undergo stereotypical abscission after cell division (PubMed:28860385). Accumulates to the pericentrosomal region following interaction with KATNA1 (By similarity). {ECO:0000250|UniProtKB:Q9P1Y5, ECO:0000269|PubMed:28860385}.
uniprot
proteins