INTS9
entrez
55756
canonical
uniprot
Q9NV88
canonical
ensembl
ENSG00000104299
resolver
ensp
ENSP00000398208
resolver
ensp
ENSP00000429065
resolver
ensp
ENSP00000430943
resolver
ensp
ENSP00000637932
resolver
ensp
ENSP00000637933
resolver
ensp
ENSP00000701549
resolver
genesymbol
INTS9
resolver
genesymbol_syn
RC74
resolver
hgnc
HGNC:25592
resolver
uniprot
B7Z560
resolver
uniprot
B7Z6M5
resolver
uniprot
O00224
resolver
uniprot
Q8TB16
resolver
uniprot_entry
INT9_HUMAN
resolver
uniprot_sec
B7Z560
resolver
uniprot_sec
B7Z6M5
resolver
uniprot_sec
O00224
resolver
uniprot_sec
Q8TB16
resolver
amino_acid_sequence
MKLYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLKDGNAFLDKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILISNYHCMMALPYITEHTGFTGTVYATEPTVQIGRLLMEELVNFIERVPKAQSASLWKNKDIQRLLPSPLKDAVEVSTWRRCYTMQEVNSALSKIQLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGSSLLTTHPQPMDQASLKNSDVLVLTGLTQIPTANPDGMVGEFCSNLALTVRNGGNVLVPCYPSGVIYDLLECLYQYIDSAGLSSVPLYFISPVANSSLEFSQIFAEWLCHNKQSKVYLPEPPFPHAELIQTNKLKHYPSIHGDFSNDFRQPCVVFTGHPSLRFGDVVHFMELWGKSSLNTVIFTEPDFSYLEALAPYQPLAMKCIYCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPPPAQSHRMDLMIDCQPPAMSYRRAEVLALPFKRRYEKIEIMPELADSLVPMEIKPGISLATVSAVLHTKDNKHLLQPPPRPAQPTSGKKRKRVSDDVPDCKVLKPLLSGSIPVEQFVQTLEKHGFSDIKVEDTAKGHIVLLQEAETLIQIEEDSTHIICDNDEMLRVRLRDLVLKFLQKF
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:33548203, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:22252320, PubMed:26308897, PubMed:30737432). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:22252320, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33548203, ECO:0000269|PubMed:38570683}.
uniprot
proteins
mass_dalton
73814
uniprot
proteins
mutagenesis
MUTAGEN 280..290; /note="EFCSNLALTVR->RFCMNLAATVA: Abolished interaction with BRAT1."; /evidence="ECO:0000269|PubMed:39032490"; MUTAGEN 283; /note="S->M: Abolished interaction with BRAT1."; /evidence="ECO:0000269|PubMed:39032490"; MUTAGEN 283; /note="S->R: Decreased interaction with INTS11 and BRAT1."; /evidence="ECO:0000269|PubMed:39032489"; MUTAGEN 566..570; /note="KKRKR->SSSSS: Decreased localization in the nucleus."; /evidence="ECO:0000269|PubMed:39032489"; MUTAGEN 633..635; /note="THI->PHP: Abolished interaction with INTS11."; /evidence="ECO:0000269|PubMed:28396433"; MUTAGEN 644..648; /note="RVRLR->EVRLE: Abolished interaction with INTS11."; /evidence="ECO:0000269|PubMed:28396433"; MUTAGEN 644; /note="R->E: Abolished interaction with INTS11."; /evidence="ECO:0000269|PubMed:28396433
uniprot
proteins
protein_family
INTS9 subfamily
uniprot
proteins
protein_family
Metallo-beta-lactamase superfamily
uniprot
proteins
protein_family
RNA-metabolizing metallo-beta-lactamase-like family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15684398
uniprot
proteins
pubmed
16239144
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
22252320
uniprot
proteins
pubmed
23904267
uniprot
proteins
pubmed
25201415
uniprot
proteins
pubmed
26308897
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28396433
uniprot
proteins
pubmed
29471365
uniprot
proteins
pubmed
30737432
uniprot
proteins
pubmed
33243860
uniprot
proteins
pubmed
33548203
uniprot
proteins
pubmed
33686175
uniprot
proteins
pubmed
34762484
uniprot
proteins
pubmed
36869814
uniprot
proteins
pubmed
38570683
uniprot
proteins
pubmed
39032489
uniprot
proteins
pubmed
39032490
uniprot
proteins
sequence_length
658
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15684398, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:29471365, ECO:0000269|PubMed:39032489, ECO:0000269|PubMed:39032490}. Cytoplasm {ECO:0000269|PubMed:29471365, ECO:0000269|PubMed:39032489, ECO:0000269|PubMed:39032490}.
uniprot
proteins