IDO2
entrez
169355
canonical
uniprot
Q6ZQW0
canonical
ensembl
ENSG00000188676
resolver
ensp
ENSP00000443432
resolver
ensp
ENSP00000646101
resolver
genesymbol
IDO2
resolver
genesymbol_syn
INDOL1
resolver
hgnc
HGNC:27269
resolver
uniprot
A4UD41
resolver
uniprot
F5H5G0
resolver
uniprot_entry
I23O2_HUMAN
resolver
uniprot_sec
A4UD41
resolver
uniprot_sec
F5H5G0
resolver
activity_regulation
ACTIVITY REGULATION: Activity is inhibited by D-1MT (1-methyl-D-tryptophan) and MTH-trp (methylthiohydantoin-DL-tryptophan) but not L-1MT (1-methyl-L-tryptophan). {ECO:0000269|PubMed:17671174}.
uniprot
proteins
amino_acid_sequence
MEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIANKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSRNLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGFILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSGWKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYHITMVTKYLITAAAKAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG
uniprot
proteins
ec_number
1.13.11.-
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885). {ECO:0000269|PubMed:17671174, ECO:0000303|PubMed:25691885}.
uniprot
proteins
mass_dalton
45424
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
uniprot
proteins
protein_family
3-dioxygenase family
uniprot
proteins
protein_family
Indoleamine 2
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17499941
uniprot
proteins
pubmed
17671174
uniprot
proteins
pubmed
18418598
uniprot
proteins
pubmed
25394548
uniprot
proteins
pubmed
25477879
uniprot
proteins
pubmed
25691885
uniprot
proteins
pubmed
25950090
uniprot
proteins
sequence_length
407
uniprot
proteins