Bfsp1
entrez
25394
canonical
uniprot
Q02435
canonical
ensembl
ENSRNOG00000005707
resolver
ensp
ENSRNOP00000007727
resolver
genesymbol
Bfsp1
resolver
uniprot_entry
BFSP1_RAT
resolver
amino_acid_sequence
MYRRSYVFQARQERYERAQPAGPTAQPGGTAPGLAALQALGERVAAQVQRARALQQRHAGLRRQLYAFQRLGEQPGPEEALARHVEANLQRARDLAAEHARLERQEAEAQRALDEFRSKYENECECQLVLKEMLERLNKEADEALLRNLHLQLEAQFLQADISVAKDRYKKNLLEIQTYITILQQIIQTAPQVSLVTGGMREEKLLTEREVAALRNQLDEGREAVTHLQAQKAELQAQTTALEQAIKHAHECYDDEIQLYNGQIENLRKEIEEAERSLERSSYDCRQLAVAQQTLRNELDRYHRIIEIEGNRLSSVFIETPISLITPSHGASLSLGSNVKDLTRAVQDITAAKPRQKALPKSLPKRKEIIAQDKVDETLEDAPLKTLQEPKAVQGELTGDGDSQLGAGGGHEVSPTQEGGPEDVPDGSQISKAFGKLCKVVKERVSGHKEPVPEPPADLFTKGRHILVTGESSFVDPEFYSSSIPARGGVVVSIEEDSMHHDGHVEPSPGQPMPPVENGQGVPQGREGAHSNHQQVTDKNGIRAKEPKDLEEKDDDSRKDDEAGRRPCPVIIPGPDGPSTTHSQTSGSNQGGPEGPGSKSSSLLAKSPSKALSFKKV
uniprot
proteins
function
FUNCTION: Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). Involved in altering the calcium regulation of MIP water permeability (By similarity). {ECO:0000250|UniProtKB:A2AMT1, ECO:0000250|UniProtKB:Q12934}.
uniprot
proteins
mass_dalton
68038
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved during lens cell fiber differentiation with increased fragmentation as fiber cell age increases. {ECO:0000250|UniProtKB:Q06002}.; PTM: [Filensin C-terminal fragment]: Myristoylated at Gly-427 following proteolytic cleavage at Asp-426. {ECO:0000250|UniProtKB:Q06002}.; PTM: [Filensin N-terminal fragment]: Acetylated at Ala-35 following proteolytic cleavage at Leu-34. {ECO:0000250|UniProtKB:Q06002}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
1378722
uniprot
proteins
pubmed
18449355
uniprot
proteins
sequence_length
617
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18449355}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q06002}; Cytoplasmic side {ECO:0000250|UniProtKB:Q06002}. Cytoplasm {ECO:0000269|PubMed:18449355}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q06002}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q06002}.
uniprot
proteins