Nefm
entrez
18040
canonical
uniprot
P08553
canonical
ensembl
ENSMUSG00000022054
resolver
ensp
ENSMUSP00000022638
resolver
enst
ENSMUST00000022638
resolver
genesymbol
Nefm
resolver
genesymbol_syn
Nef3
resolver
genesymbol_syn
Nfm
resolver
uniprot
A0A0R4J036
resolver
uniprot
A2VCT5
resolver
uniprot
Q0VDM8
resolver
uniprot
Q3HRJ6
resolver
uniprot
Q3TNS4
resolver
uniprot
Q3TPK2
resolver
uniprot
Q61961
resolver
uniprot
Q8BQ20
resolver
uniprot_entry
A0A0R4J036_MOUSE
resolver
uniprot_entry
NFM_MOUSE
resolver
uniprot_sec
A2VCT5
resolver
uniprot_sec
Q0VDM8
resolver
uniprot_sec
Q3HRJ6
resolver
uniprot_sec
Q3TNS4
resolver
uniprot_sec
Q3TPK2
resolver
uniprot_sec
Q61961
resolver
uniprot_sec
Q8BQ20
resolver
amino_acid_sequence
MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSALAPRLAYSSAMLSSAESSLDFSQSSSLLNGGSGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEESSMVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLECHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFSGSITGPLYTHRQPSVTISSKIQKTKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEETLTAIAEELAASAKEEKEEAEEKEEEPEAEKSPVKSPEAKEEEEEGEKEEEEEGQEEEEEEDEGVKSDQAEEGGSEKEGSSEKDEGEQEEEEGETEAEGEGEEAEAKEEKKIEGKVEEVAVKEEIKVEKPEKAKSPMPKSPVEEVKPKPEAKAGKGEQKEEEKVEEEKKEVTKESPKEEKVEKKEEKPKDVADKKKAESPVKEKAVEEVITISKSVKVSLEKDTKEEKPQPQEKVKEKAEEEGGSEEEGSDRSPQESKKEDIAINGEVEGKEEEEQETQEKGSGREEEKGVVTNGLDVSPAEEKKGEDSSDDKVVVTKKVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQGD
uniprot
proteins
function
FUNCTION: Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (PubMed:22723690). {ECO:0000269|PubMed:22723690}.
uniprot
proteins
mass_dalton
95916
uniprot
proteins
post_translational_modification
PTM: There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.; PTM: Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function.; PTM: Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization. {ECO:0000250}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
16452088
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22723690
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
3036526
uniprot
proteins
pubmed
3103856
uniprot
proteins
sequence_length
848
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22723690}. Cell projection, axon {ECO:0000269|PubMed:22723690}.
uniprot
proteins