GP6
entrez
51206
canonical
uniprot
Q9HCN6
canonical
ensembl
ENSG00000088053
resolver
ensembl
ENSG00000274050
resolver
ensembl
ENSG00000274566
resolver
ensembl
ENSG00000275633
resolver
ensembl
ENSG00000275931
resolver
ensembl
ENSG00000276065
resolver
ensembl
ENSG00000276211
resolver
ensembl
ENSG00000277439
resolver
ensembl
ENSG00000278316
resolver
ensembl
ENSG00000278670
resolver
ensp
ENSP00000308782
resolver
ensp
ENSP00000334552
resolver
ensp
ENSP00000394922
resolver
genesymbol
GP6
resolver
hgnc
HGNC:14388
resolver
uniprot
Q9HCN7
resolver
uniprot
Q9UIF2
resolver
uniprot_entry
GPVI_HUMAN
resolver
uniprot_sec
Q9HCN7
resolver
uniprot_sec
Q9UIF2
resolver
amino_acid_sequence
MSPSPTALFCLGLCLGRVPAQSGPLPKPSLQALPSSLVPLEKPVTLRCQGPPGVDLYRLEKLSSSRYQDQAVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQLELVATGVFAKPSLSAQPGPAVSSGGDVTLQCQTRYGFDQFALYKEGDPAPYKNPERWYRASFPIITVTAAHSGTYRCYSFSSRDPYLWSAPSDPLELVVTGTSVTPSRLPTEPPSPVAEFSEATAELTVSFTNEVFTTETSRSITASPKESDSPAGPARQYYTKGNLVRICLGAVILIILAGFLAEDWHSRRKRLRHRGRAVQRPLPPLPPLPLTRKSNGGQDGGRQDVHSRGLCS
uniprot
proteins
disease_involvement
DISEASE: Bleeding disorder, platelet-type, 11 (BDPLT11) [MIM:614201]: A mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen. {ECO:0000269|PubMed:19549989, ECO:0000269|PubMed:19552682}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. {ECO:0000269|PubMed:10961879, ECO:0000269|PubMed:18955485}.
uniprot
proteins
mass_dalton
36866
uniprot
proteins
mutagenesis
MUTAGEN 61; /note="K->A: Increases collagen binding."; /evidence="ECO:0000269|PubMed:16405521"; MUTAGEN 79; /note="K->E: Dramatically reduces collagen binding."; /evidence="ECO:0000269|PubMed:16405521"; MUTAGEN 80; /note="R->A: Reduces collagen binding."; /evidence="ECO:0000269|PubMed:16405521"; MUTAGEN 92; /note="N->A: Reduces collagen binding (65 to 70%)."; /evidence="ECO:0000269|PubMed:16014566"; MUTAGEN 94; /note="S->A: Reduces collagen binding (65 to 70%)."; /evidence="ECO:0000269|PubMed:16014566"; MUTAGEN 95; /note="L->H: No effect on collagen binding."; /evidence="ECO:0000269|PubMed:16014566"; MUTAGEN 186; /note="R->A: Reduces collagen binding."; /evidence="ECO:0000269|PubMed:16405521
uniprot
proteins
post_translational_modification
PTM: N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX). {ECO:0000269|PubMed:16014566}.
uniprot
proteins
pubmed
10961879
uniprot
proteins
pubmed
11027634
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16014566
uniprot
proteins
pubmed
16405521
uniprot
proteins
pubmed
16861347
uniprot
proteins
pubmed
18955485
uniprot
proteins
pubmed
19549989
uniprot
proteins
pubmed
19552682
uniprot
proteins
pubmed
20946164
uniprot
proteins
pubmed
21552524
uniprot
proteins
pubmed
9295288
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 268..288; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins