ESYT1
entrez
23344
canonical
uniprot
Q9BSJ8
canonical
ensembl
ENSG00000139641
resolver
ensp
ENSP00000267113
resolver
ensp
ENSP00000377612
resolver
genesymbol
ESYT1
resolver
genesymbol_syn
FAM62A
resolver
genesymbol_syn
KIAA0747
resolver
genesymbol_syn
MBC2
resolver
hgnc
HGNC:29534
resolver
uniprot
A0FGR7
resolver
uniprot
A8K2S2
resolver
uniprot
O94848
resolver
uniprot
Q6PJN4
resolver
uniprot
Q9H6J1
resolver
uniprot
Q9H6W2
resolver
uniprot
Q9Y416
resolver
uniprot_entry
ESYT1_HUMAN
resolver
uniprot_sec
A0FGR7
resolver
uniprot_sec
A8K2S2
resolver
uniprot_sec
O94848
resolver
uniprot_sec
Q6PJN4
resolver
uniprot_sec
Q9H6J1
resolver
uniprot_sec
Q9H6W2
resolver
uniprot_sec
Q9Y416
resolver
amino_acid_sequence
MERSPGEGPSPSPMDQPSAPSDPTDQPPAAHAKPDPGSGGQPAGPGAAGEALAVLTSFGRRLLVLIPVYLAGAVGLSVGFVLFGLALYLGWRRVRDEKERSLRAARQLLDDEEQLTAKTLYMSHRELPAWVSFPDVEKAEWLNKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQTFTFTRVELGEKPLRIIGVKVHPGQRKEQILLDLNISYVGDVQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLIGDLPFVGAVSMFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQWGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQASVLDDWFPLQGGQGQVHLRLEWLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKDDSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMRILYLDSSEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQELEVEVFDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSIYMERAEDLPLRKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQVRGEGTGVLGSLSLPLSELLVADQLCLDRWFTLSSGQGQVLLRAQLGILVSQHSGVEAHSHSYSHSSSSLSEEPELSGGPPHITSSAPELRQRLTHVDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVARWYDLMDNKDKGSS
uniprot
proteins
function
FUNCTION: Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}.
uniprot
proteins
mass_dalton
122856
uniprot
proteins
mutagenesis
MUTAGEN 406; /note="D->A: No effect on translocation to sites of contact between the endoplasmic reticulum and the cell membrane."; /evidence="ECO:0000269|PubMed:24183667"; MUTAGEN 663; /note="D->A: Abolishes location at the cell membrane; when associated with A-675 and 722-A--A-729."; /evidence="ECO:0000269|PubMed:23791178"; MUTAGEN 675; /note="D->A: Abolishes location at the cell membrane; when associated with A-675 and 722-A--A-729."; /evidence="ECO:0000269|PubMed:23791178"; MUTAGEN 722..729; /note="DKDLDKDD->AKALAKAA: Abolishes location at the cell membrane; when associated with A-663 and A-675."; /evidence="ECO:0000269|PubMed:23791178"; MUTAGEN 724; /note="D->A: Loss of translocation to sites of contact between the endoplasmic reticulum and the cell membrane."; /evidence="ECO:0000269|PubMed:24183667
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser residues in insulin-treated adipocytes (in vitro); this promotes interaction with SLC2A4. {ECO:0000250}.
uniprot
proteins
protein_family
Extended synaptotagmin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
17360437
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22250200
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23791178
uniprot
proteins
pubmed
24183667
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29469807
uniprot
proteins
pubmed
38758649
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
1104
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29469807}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:29469807}; Peripheral membrane protein {ECO:0000269|PubMed:29469807}. Note=Localizes primarily to the endoplasmic reticulum (PubMed:29469807). Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:22250200, PubMed:29469807). {ECO:0000269|PubMed:22250200, ECO:0000269|PubMed:29469807}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 63..83; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins