Tax1bp1
entrez
52440
canonical
uniprot
Q3UKC1
canonical
ensembl
ENSMUSG00000004535
resolver
ensp
ENSMUSP00000079548
resolver
ensp
ENSMUSP00000195096
resolver
ensp
ENSMUSP00000195105
resolver
enst
ENSMUST00000080723
resolver
genesymbol
Tax1bp1
resolver
uniprot
Q91YT6
resolver
uniprot
Q9CVF0
resolver
uniprot
Q9DC45
resolver
uniprot_entry
TAXB1_MOUSE
resolver
uniprot_sec
Q91YT6
resolver
uniprot_sec
Q9CVF0
resolver
uniprot_sec
Q9DC45
resolver
amino_acid_sequence
MTSFQEVQLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHSKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRAASPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTLKEKEELLKLIAVLEKETAQLREQVGRMERELSQEKGRCEQLQAEQKGLLEVSQSLRVENEEFMKRYSDATAKVQQLEEDIVSVTHKAIEKETDLDSLKDKLRKAQHEREQLECQLQTEKDEKELYKVHLKNTEIENTKLVSEIQTLKNLDGNKESMITHFKEEISKLQSCLADKENLYRALLLTTSNKEDTLFLKEQLRKAEEQVQATRQELIFLTKELSDAVNVRDKTMADLHTARLENERVKKQLADTLAELQLHAVKKDQEKTDTLEHELRREVEDLKLRLQMAADHYREKFKECQRLQKQINKLSDQAASTNSVFTKKMGSQQKVNDASINTDPAASTSASAVDVKPAASCAETGFDMSTKDHVCEMTKEIAEKIEKYNKCKQLLQDEKTKCNKYAEELAKMELKWKEQVKIAENVKLELAEVEDNYKVQLAEKEKEINGLASYLENLSREKELTKSLEDQKGRKLEGQSPQQVSRCLNTCSEQNGLLPPLSSAQPVLQYGNPYSAQETRDGADGAFYPDEIQRPPVRVPSWEDNVVCSQPARNLSRPDGLEDPEDSREDENVPIPPDPANQHLRSHGAGFCFDSSFDVHKKCPLCELMFPPNYDQTKFEEHVESHWKVCPMCSEQFPPDYDQQGFERHVQTHFDQNVLNFD
uniprot
proteins
function
FUNCTION: Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:18239685, PubMed:33207181). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates. Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (By similarity). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:18239685). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (By similarity). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis. Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (By similarity). Mediates the autophagic degradation of other substrates including TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q86VP1, ECO:0000269|PubMed:18239685, ECO:0000269|PubMed:33207181}.
uniprot
proteins
mass_dalton
93630
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation. {ECO:0000250}.
uniprot
proteins
pubmed
10435631
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15509224
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18239685
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33207181
uniprot
proteins
sequence_length
814
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86VP1}. Mitochondrion {ECO:0000250|UniProtKB:Q86VP1}. Preautophagosomal structure {ECO:0000250|UniProtKB:Q86VP1}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q86VP1}.
uniprot
proteins