Rbbp4
entrez
19646
canonical
uniprot
Q60972
canonical
ensembl
ENSMUSG00000057236
resolver
ensp
ENSMUSP00000099658
resolver
enst
ENSMUST00000102598
resolver
genesymbol
Rbbp4
resolver
genesymbol_syn
Rbap48
resolver
uniprot
A2A875
resolver
uniprot_entry
RBBP4_MOUSE
resolver
uniprot_sec
A2A875
resolver
amino_acid_sequence
MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS
uniprot
proteins
function
FUNCTION: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (By similarity). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (By similarity). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (By similarity). Component of the PRC2 complex, which promotes repression of homeotic genes during development (By similarity). Component of the NURF (nucleosome remodeling factor) complex (By similarity). {ECO:0000250|UniProtKB:Q09028}.
uniprot
proteins
mass_dalton
47656
uniprot
proteins
protein_family
WD repeat RBAP46/RBAP48/MSI1 family
uniprot
proteins
pubmed
10866654
uniprot
proteins
pubmed
10984530
uniprot
proteins
pubmed
11788710
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
19026780
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
28554894
uniprot
proteins
pubmed
34180153
uniprot
proteins
pubmed
7503932
uniprot
proteins
pubmed
9702189
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q09028}. Chromosome, telomere {ECO:0000250|UniProtKB:Q09028}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000250|UniProtKB:Q09028}.
uniprot
proteins