RPA4
entrez
29935
canonical
uniprot
Q13156
canonical
ensembl
ENSG00000204086
resolver
ensp
ENSP00000362131
resolver
enst
ENST00000373040
resolver
genesymbol
RPA4
resolver
hgnc
HGNC:30305
resolver
uniprot
Q3SY03
resolver
uniprot_entry
RFA4_HUMAN
resolver
uniprot_sec
Q3SY03
resolver
amino_acid_sequence
MSKSGFGSYGSISAADGASGGSDQLCERDATPAIKTQRPKVRIQDVVPCNVNQLLSSTVFDPVFKVRGIIVSQVSIVGVIRGAEKASNHICYKIDDMTAKPIEARQWFGREKVKQVTPLSVGVYVKVFGILKCPTGTKSLEVLKIHVLEDMNEFTVHILETVNAHMMLDKARRDTTVESVPVSPSEVNDAGDNDESHRNFIQDEVLRLIHECPHQEGKSIHELRAQLCDLSVKAIKEAIDYLTVEGHIYPTVDREHFKSAD
uniprot
proteins
function
FUNCTION: As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. {ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19942684, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:20545304}.
uniprot
proteins
mass_dalton
28868
uniprot
proteins
protein_family
Replication factor A protein 2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
19116208
uniprot
proteins
pubmed
19942684
uniprot
proteins
pubmed
19996105
uniprot
proteins
pubmed
20545304
uniprot
proteins
pubmed
7760808
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19942684}. Note=Localizes to DNA repair foci after DNA damage.
uniprot
proteins