Acp5
entrez
11433
canonical
uniprot
Q05117
canonical
ensembl
ENSMUSG00000001348
resolver
ensp
ENSMUSP00000065425
resolver
ensp
ENSMUSP00000110970
resolver
ensp
ENSMUSP00000127128
resolver
ensp
ENSMUSP00000149597
resolver
ensp
ENSMUSP00000150903
resolver
ensp
ENSMUSP00000268390
resolver
enst
ENSMUST00000069330
resolver
enst
ENSMUST00000115315
resolver
enst
ENSMUST00000165735
resolver
enst
ENSMUST00000213815
resolver
enst
ENSMUST00000217643
resolver
genesymbol
Acp5
resolver
genesymbol_syn
T5ap
resolver
genesymbol_syn
Trap
resolver
uniprot_entry
PPA5_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Not inhibited by L(+)-tartrate. Synthesized as a single chain proenzyme, with low enzymatic activity. Proteolytic cleavage converts ACP5 into a more active form. {ECO:0000250|UniProtKB:P13686}.
uniprot
proteins
amino_acid_sequence
MDSWVVLLGLQIIWLPLLTHGTAPTPTLRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQTMGADFIMSLGDNFYFTGVHDASDKRFQETFEDVFSDRALRNIPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPYYRLRFKIPRTNITVAIFMLDTVMLCGNSDDFASQQPKMPRDLGVARTQLSWLKKQLAAAKEDYVLVAGHYPIWSIAEHGPTRCLVKNLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSVRHQRKVPNGYLRFHYGSEDSLGGFTHVEISPKEMTIIYVEASGKSLFKTSLPRRPRP
uniprot
proteins
ec_number
3.1.3.2
uniprot
proteins
function
FUNCTION: Functions as a binuclear Fe(III)-Fe(II) acid phosphatase that hydrolyzes phosphate esters to alcohols and phosphate under acidic conditions (PubMed:22158965). Dephosphorylates a broad range of substrates, including adenosine 5'-diphosphate (ADP), adenosine 5'-triphosphate (ATP), as well as larger phosphoproteins such as osteopontin (SPP1), a highly phosphorylated bone matrix protein, bone sialoprotein (IBSP) and synthetic compounds such as para-nitrophenyl phosphate (p-NPP) (By similarity). Through the dephosphorylation of bone matrix proteins, plays a crucial role in normal cartilage mineralization during skeletal development and in maintaining and remodeling bone integrity in adults (PubMed:36569898). Promotes osteoclast migration by dephosphorylating SPP1, which binds osteoclasts to the bone matrix (By similarity). Also involved in immune regulation and macrophage function, contributes to the breakdown of internalized pathogens within lysosomes (PubMed:11168643). Regulates immune cell recruitment during infection, partly via interaction with SPP1 (PubMed:36569898). The uncleaved form (isoform 5a) functions primarily in immune regulation rather than bone resorption (PubMed:11168643). May contribute to the removal of mannose-6-phosphate (Man6P) from lysosomal proteins after their delivery to lysosomes, acting in concert with ACP2 (PubMed:22158965). {ECO:0000250|UniProtKB:P29288, ECO:0000269|PubMed:11168643, ECO:0000269|PubMed:22158965, ECO:0000269|PubMed:36569898}.
uniprot
proteins
mass_dalton
36807
uniprot
proteins
post_translational_modification
PTM: Produced as a low-activity single-chain proenzyme and becomes activated through proteolytic cleavage of a surface loop by lysosomal, intracellular, or secreted proteases. This cleavage generates two subunits of approximately 16-17 kDa and 20-23 kDa that remain connected by disulfide bonds, forming the active catalytic form (isoform 5b). {ECO:0000250|UniProtKB:P13686}.
uniprot
proteins
pubmed
10639488
uniprot
proteins
pubmed
11168643
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22158965
uniprot
proteins
pubmed
23478294
uniprot
proteins
pubmed
28303318
uniprot
proteins
pubmed
36569898
uniprot
proteins
pubmed
8256664
uniprot
proteins
pubmed
8359686
uniprot
proteins
pubmed
8898228
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:10639488}. Secreted {ECO:0000250|UniProtKB:P13686}. Note=The uncleaved form (isoform 5a) is secreted by macrophage and dendritic cell. The cleaved form (isoform 5b) is secreted by osteoclasts. {ECO:0000250|UniProtKB:P13686}.
uniprot
proteins