Adam2
entrez
56806
canonical
uniprot
Q63202
canonical
ensembl
ENSRNOG00000017027
resolver
ensp
ENSRNOP00000061122
resolver
genesymbol
Adam2
resolver
genesymbol_syn
Ftnb
resolver
uniprot_entry
ADAM2_RAT
resolver
amino_acid_sequence
MWLLLLLLSGLSRLGGLSEPQTEGTREKLHVQVTVPEKIRSITSEGYETQVTYSLKIEGKTYILNLMQKAFLPPNFRVYSYDSTGIMRPLEQKFQNICYFQGYIEGYPNSMVIVSTCTGLRGVLQFGNVSYGIEPLESSSGFEHVIYQVEPKKGDTLLYAEKDMDLRDPQYKIRSIKPQRTVSHYLEIHIVVEKQMFEHIGADTAVVTQKIFQLIGLTNAIFAPFNLTVILSSLEFWMDENKISTTGDANKLLYRFLKWKQSYLVLRPHDMAFLLVYRDTTDYVGATYQGKMCDKNYAGGVALHPKAVTLESLAIILVQLLSLSMGVAYDDVNTCQCGVPICVMNPEALHSSGVRSFSNCSMEDFSKFIVSQSSHCLQNQPHLQPSYKMAVCGNGELEEGEVCDCGQEGCDDKPPPCCNPTTCQLSEGSTCSTGSCCDASCNLKAKGELCRPANQECDVTEYCNGTSEVCEEDFFVQDGHPCAEQKWICINGTCQSGAQQCRDLFGTDADYGTKECYSELNSKSDISGSCGITPTGYKDCAPNDRMCGKLICIYQSEDILKMRSAIVIYANISGQICISLEYPPGHKESKKMCVRDGTVCGSGKVCLNQECVEDTFLNYDCTPEKCNHHGVCNNKKHCHCEPTYLPPDCKNTEDTWPGGSVDSGNQQRAESIPARSYVASAYRSKSARWPFFLIIPFYVVILVLIGMLVKVYSQRKKWRMDDFSSEEQFESESESKD
uniprot
proteins
function
FUNCTION: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
82311
uniprot
proteins
post_translational_modification
PTM: The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa. {ECO:0000250}.
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9358007
uniprot
proteins
sequence_length
737
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 689..709; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins