Krt2
entrez
16681
canonical
uniprot
Q3TTY5
canonical
ensembl
ENSMUSG00000064201
resolver
ensp
ENSMUSP00000023712
resolver
enst
ENSMUST00000023712
resolver
genesymbol
Krt2
resolver
genesymbol_syn
K2e
resolver
genesymbol_syn
Krt2-17
resolver
genesymbol_syn
Krt2a
resolver
uniprot
Q0VBW1
resolver
uniprot
Q61869
resolver
uniprot_entry
K22E_MOUSE
resolver
uniprot_sec
Q0VBW1
resolver
uniprot_sec
Q61869
resolver
amino_acid_sequence
MSCQISCRSRRGGGGGGGGGFRGFSSGSAVVSGGSRRSNTSFSCISRHGGGRGGSGGGGFGSQSLVGLGGYKSISSSVAGNSGGYGGSSFGGSSGFGGGRGFGGGQGFGGSGGFGGGSGFGGGQGFGGGSRFGGGSGFGGGGFGGGSFGGGRFGGGPGGFGGPGGFPGGGIHEVSVNQSLLQPLDVKVDPEIQNVKSQEREQIKTLNNKFASFIDKVRFLEQQNQVLRTKWELLQQLDVGSRTTNLDPIFQAYIGMLKKQVDRLSAERTSQESELNNMQDLVEDFKKKYEDEINKRTSAENDFVTIKKDVDSCYMDKTELQARLDILAQEVNFLRTLYDAELSQLQQDVTDTNVILSMDNNRNLDLDSIIAEVQNQYEMIAHKSKAESEELYHSKYEELQVTAVKHGDSLKEIKMEISELNRTIQRLQGEISHVKKQCKGVQDSIADAEQRGEHAIKDARGKLTDLEEALQQCREDLARLLRDYQELMNTKLSLDVEIATYRKLLEGEECRMSGDFSDNVSVSITSSTISSSVASKTGFGSGGQSSGGRGSYGGRGGGGGGGSTYGSGGRSSGSRGSGSGSGGGGYSSGGGSRGGSGGGYGSGGGSRGGSGGGYGSGGGSGSGGGYSSGGGSRGGSGGGGVSSGGGSRGGSSSGGGSRGGSSSGGGGYSSGGGSRGGSSSGGAGSSSEKGGSGSGEGCGSGVTFSFR
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Krt2 are a cause of ichthyosis bullosa of siemens (IBS). IBS is a rare autosomal dominant disorder displaying a type of epidermolytic hyperkeratosis characterized by extensive blistering from birth. Hyperkeratoses and shedding of the outer layers of the epidermis (molting) are observed in later weeks.
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in suprabasal keratinocytes of stratified epidermis. Forms heteropolymers with type I keratins (e.g., KRT10), assembling into keratin intermediate filament networks that support epidermal differentiation and barrier integrity (PubMed:24751727, PubMed:26603179). Contributes to terminal differentiation and cornification of keratinocytes and plays a role in establishing the epidermal barrier, particularly in plantar (sole) skin and in the epidermis of the ear and tail (PubMed:24751727, PubMed:26603179). {ECO:0000269|PubMed:24751727, ECO:0000269|PubMed:26603179}.
uniprot
proteins
mass_dalton
70923
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
12533510
uniprot
proteins
pubmed
15118396
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
2448177
uniprot
proteins
pubmed
24751727
uniprot
proteins
pubmed
26603179
uniprot
proteins
pubmed
7508961
uniprot
proteins
pubmed
9378767
uniprot
proteins
sequence_length
707
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24751727}.
uniprot
proteins