Sesn2
entrez
230784
canonical
uniprot
P58043
canonical
ensembl
ENSMUSG00000028893
resolver
ensp
ENSMUSP00000030724
resolver
enst
ENSMUST00000030724
resolver
genesymbol
Sesn2
resolver
uniprot_entry
SESN2_MOUSE
resolver
amino_acid_sequence
MIVADSECHSEIKGYLPFTRGGVAGPETREEHREGQARRGSRGPSAFIPVEEILREGAESLEQHLGLEALMSSGRVDNLAVVMGLHPDYLSSFWRLHYLLLHTDGPLASSWRHYIAIMAAARHQCSYLVGSHMTEFLQTGGDPEWLLGLHRAPEKLRKLSEVNKLLAHRPWLITKEHIQALLKTGEHSWSLAELIQALVLLTHCHSLASFVFGCGILPEGDAEGSPASQAPSPPSEQGTPPSGDPLNNSGGFEAARDVEALMERMRQLQESLLRDEGASQEEMENRFELEKSESLLVTPSADILEPSPHPDILCFVEDPAFGYEDFTRRGTQAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQVACSLTYNTIAMHSGVDTSMLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKIYIKTVACYPEKTTRRMYNLFWRHFRHSEKVHVNLLLLEARMQAALLYALRAITRYMT
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
function
FUNCTION: Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex (PubMed:18692468, PubMed:25259925). In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling (PubMed:18692468, PubMed:25259925). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:18692468, PubMed:25259925). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses (By similarity). May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed (By similarity). {ECO:0000250|UniProtKB:P58004, ECO:0000269|PubMed:18692468, ECO:0000269|PubMed:23274085, ECO:0000269|PubMed:24947615, ECO:0000269|PubMed:25259925}.
uniprot
proteins
mass_dalton
54377
uniprot
proteins
mutagenesis
MUTAGEN 419; /note="R->A: Unable to inhibit TORC1 signaling; when associated with A-422 and A-426."; /evidence="ECO:0000269|PubMed:25259925"; MUTAGEN 422; /note="K->A: Unable to inhibit TORC1 signaling; when associated with A-419 and A-426."; /evidence="ECO:0000269|PubMed:25259925"; MUTAGEN 426; /note="K->A: Unable to inhibit TORC1 signaling; when associated with A-419 and A-422."; /evidence="ECO:0000269|PubMed:25259925
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ULK1 at multiple sites. {ECO:0000250|UniProtKB:P58004}.; PTM: Ubiquitinated at Lys-175 by RNF167 via 'Lys-63'-linked polyubiquitination in response to leucine deprivation: ubiquitination promotes SESN2-interaction with the GATOR2 complex, leading to inhibit the TORC1 signaling pathway. Deubiquitinated at Lys-175 by STAMBPL1, promoting the TORC1 signaling pathway. Ubiquitinated by RNF186; ubiquitination mediates proteasomal degradation. {ECO:0000250|UniProtKB:P58004}.
uniprot
proteins
protein_family
Sestrin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18692468
uniprot
proteins
pubmed
22958918
uniprot
proteins
pubmed
23274085
uniprot
proteins
pubmed
24947615
uniprot
proteins
pubmed
25040165
uniprot
proteins
pubmed
25259925
uniprot
proteins
pubmed
25377878
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P58004}.
uniprot
proteins