Syt3
entrez
25731
canonical
uniprot
P40748
canonical
ensembl
ENSRNOG00000019318
resolver
ensp
ENSRNOP00000026251
resolver
enst
ENSRNOT00000026251
resolver
genesymbol
Syt3
resolver
uniprot
A0A0G2JSR2
resolver
uniprot
Q925B7
resolver
uniprot_entry
A0A0G2JSR2_RAT
resolver
uniprot_entry
SYT3_RAT
resolver
uniprot_sec
Q925B7
resolver
amino_acid_sequence
MSGDYEDDLCRRALILVSDLCARIRDADTNDRCQEFNELRIRGYPRGPDADISVSLLSVIVTFCGIVLLGVSLFVSWKLCWVPWRDKGGSAVGGGPLRKDLAPGVGLAGLVGGGGHHLGASLGGHPLLGGPHHHAHPAHHPPFAELLEPGGLGGSEPPEPSYLDMDSYPEAAVASVVAAGVKPSQTSPELPSEGGTGSGLLLLPPSGGGLPSAQSHQQVTSLAPTTRYPALPRPLTQQTLTTQADPSSEERPPALPLPLPGGEEKAKLIGQIKPELYQGTGPGGRRTGGGSGEAGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPIFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDILEGGSEKADLGELNFSLCYLPTAGLLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPEAADPHGREHWAEMLANPRKPVEHWHQLVEEKTLSSFTKGGKGLSEKENSE
uniprot
proteins
function
FUNCTION: Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (PubMed:11823420, PubMed:18508778). Plays a role in dendrite formation by melanocytes (By similarity). {ECO:0000250|UniProtKB:Q9BQG1, ECO:0000269|PubMed:11823420, ECO:0000269|PubMed:18508778}.
uniprot
proteins
mass_dalton
63313
uniprot
proteins
mutagenesis
MUTAGEN 334; /note="D->N: Abolishes Ca(2+)-dependent phospholipid-binding."; /evidence="ECO:0000269|PubMed:11823420
uniprot
proteins
protein_family
Synaptotagmin family
uniprot
proteins
pubmed
10545502
uniprot
proteins
pubmed
11823420
uniprot
proteins
pubmed
18508778
uniprot
proteins
pubmed
20173762
uniprot
proteins
pubmed
8163462
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11823420}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 55..75; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins