Il36a
entrez
54448
canonical
uniprot
Q9JLA2
canonical
ensembl
ENSMUSG00000026984
resolver
ensp
ENSMUSP00000028361
resolver
enst
ENSMUST00000028361
resolver
genesymbol
Il36a
resolver
genesymbol_syn
Fil1e
resolver
genesymbol_syn
Il1e
resolver
genesymbol_syn
Il1f6
resolver
genesymbol_syn
Il1h1
resolver
uniprot
Q149U6
resolver
uniprot_entry
IL36A_MOUSE
resolver
uniprot_entry
Q149U6_MOUSE
resolver
amino_acid_sequence
MNKEKELRAASPSLRHVQDLSSRVWILQNNILTAVPRKEQTVPVTITLLPCQYLDTLETNRGDPTYMGVQRPMSCLFCTKDGEQPVLQLGEGNIMEMYNKKEPVKASLFYHKKSGTTSTFESAAFPGWFIAVCSKGSCPLILTQELGEIFITDFEMIVVH
uniprot
proteins
function
FUNCTION: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of pro-inflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes. May play a role in pro-inflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c(+) alveolar macrophages. May be involved in T-cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c(+) cells. May be involved in CD4(+) T-cell proliferation. Induces NF-kappa B activation in macrophages. {ECO:0000269|PubMed:21860022, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23029241, ECO:0000269|PubMed:24829417}.
uniprot
proteins
mass_dalton
18015
uniprot
proteins
post_translational_modification
PTM: N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold). {ECO:0000269|PubMed:21965679}.
uniprot
proteins
protein_family
IL-1 family
uniprot
proteins
pubmed
10744718
uniprot
proteins
pubmed
11466363
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20101239
uniprot
proteins
pubmed
21860022
uniprot
proteins
pubmed
21881584
uniprot
proteins
pubmed
21965679
uniprot
proteins
pubmed
23029241
uniprot
proteins
pubmed
24829417
uniprot
proteins
sequence_length
160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UHA7}. Secreted {ECO:0000250|UniProtKB:Q9UHA7}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000250|UniProtKB:Q9UHA7}.
uniprot
proteins