Mical2
entrez
365352
canonical
uniprot
D4A1F2
canonical
ensembl
ENSRNOG00000016210
resolver
ensembl
ENSRNOG00000079050
resolver
ensp
ENSRNOP00000039759
resolver
ensp
ENSRNOP00000074877
resolver
ensp
ENSRNOP00000093313
resolver
enst
ENSRNOT00000102148
resolver
genesymbol
Mical2
resolver
genesymbol_syn
Micalcl
resolver
uniprot
A0A8I6AIG9
resolver
uniprot
F1LW55
resolver
uniprot
Q498N8
resolver
uniprot
Q4G091
resolver
uniprot
Q80WN5
resolver
uniprot_entry
A0A8I6AIG9_RAT
resolver
uniprot_entry
MICA2_RAT
resolver
uniprot_sec
F1LW55
resolver
uniprot_sec
Q498N8
resolver
uniprot_sec
Q4G091
resolver
uniprot_sec
Q80WN5
resolver
amino_acid_sequence
MGENEDEKQAQASQVFENFVQATTCKGTLQAFNILTCLLDLDPLDHRNFYTQLKSKVNTWKAKALWHKLDKRGSHKEYKRGKACSNTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDTFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVNVEFVRVREPPKDQENRKIGWRAEFLPADHALSNFEFDVIIGADGHRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDSTHYFVMTAKKQSLLDKGVILNDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAINHNGQPDVAMFDFTSMYASENAALMRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWDQGTPPLEVLAERESLYRLLPQTTPENINKNFEQYTLDPATRYPNLNVHCVRPHQVKHLYITKEMDRFPLERWGSVRRSASLSRRESDIRPNKLLTWCQQQTKGYQHVRVTDLTTSWRSGLALCAIIHSFRPELINFDSLNENDVVENNQLAFDVAKREFGILPVTTGKEMASTQEPDKLSMVMYLSKFYELFRGTPLRPMDSRRKNYGENADFGLGKTFFQNNYLNLTLPRKRTPRVDAQTEENDVNKRRRQGFNNLEELPAFSSRSLGSSQEYAKESGNQNKVKYMANQLLAKFEENTRNPSALKQDCPRVSGMGKPVLCSASRPPGTSHCPKLEESTPRLPPPLKRQFSSTVATGQVLRELNQVPASGECPGRPWRARAKSDLQLGGAENLATLPPTCQGALALSGVLRRLQQVEEKVLQKRAQNLANREFHTKNIKEKAAHLASMFGHGDLPQDKLLSKRVPHAHPPSPPSCLPSPDPAAAPSPPAADSVSPARKVLTVGKVSSGIGAAAEVLVNLYLNDHRPKTQATSPDLESLRKAEFPLSLGGRDTCYFCKKRVYVMERLSAEGHFFHRECFRCSVCAAILRVAAYAFDCDEGKFYCKLHFAHCKTSSKQRKRRAELNQQREEEGTWPEQEAARRDVPAESSCAVAAISTPEGSPPDEPISPKKSKSVPKPNSRPMEVEATSPRPSEWTSVRIGPGQDGQDVLAVRVLVTSEDSSSDTESDSGSIIGPCTEACEERPRLPESPPLSQPLTRHISLRETLTQPVSLLLHHKEPQAVPGLQRAYSLQSPSKYQNWRRKFQSNSTPMNQRALSPPKEPPPSSSSSSPSLPSSFSSASVPGHTTDDSSSPQVTYNLHSPQISRDDVSPTPIYLRRARAQGITKEIPLYLPHSPMLESTEHCLVSPDGEELRSPEEISASDGCQKALALGNSESTHKDSYPVSGKDPYLPNQMLALGAAGNTGDLSEESRMGQTGGAELSKERKLGLKKLVLTEEQKTMLLDWNDYTQEHKAGERLAQEKAENGRGNSLKPICSSTLSQAVKEKLLSQKKALGETRTPAAKAPREREVPPPKSPLRLIANAIFRSLLPSSEAGKKTSSKPETKTLPRGQPHAFTRSFSFRKLGSSKDGDQQSPGRHMAKKASAFFSLASPTSKAAQASDLSPPNPILRSRSLPNRPSKMFFATTSLPPSSKVEDVPTLLEKVSLQDAAQGPKKGASHISPLGLKDKSFESFLQECKERKDIGDFFNSPKEKGPPGNRVPSLEKLVQPVDSTSMGQVAHPSSTGQDAQAAVRTQAGKEGSSLVSSLVLVSGPGAPVTEDTSSPTSSSAEEDVETQLSSRLKEKIPRRRRKLEKQMAKQEELKRLHKAQAIQRQLEEVEERQRTSEIQGVRLEKVLRGETADSGTQDEAQLLQEWFKLVLEKNKLMRYESELLIMAQELELEDHQSRLEQKLRQKMLKDEGQKDENDLKEEQEIFEEMMQVIEQRNKLVDSLEEQRIKERTQDQHFENFVLSRGCQLSRT
uniprot
proteins
ec_number
1.14.13.225
uniprot
proteins
function
FUNCTION: Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (By similarity). {ECO:0000250|UniProtKB:O94851, ECO:0000250|UniProtKB:Q8TDZ2}.
uniprot
proteins
mass_dalton
217484
uniprot
proteins
protein_family
Mical family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1948
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O94851}. Cytoplasm {ECO:0000250|UniProtKB:Q8BML1}.
uniprot
proteins