Atp4b
entrez
11945
canonical
uniprot
P50992
canonical
ensembl
ENSMUSG00000031449
resolver
ensp
ENSMUSP00000033826
resolver
enst
ENSMUST00000033826
resolver
genesymbol
Atp4b
resolver
uniprot
Q0VBB6
resolver
uniprot
Q9D6S3
resolver
uniprot
Q9D6T2
resolver
uniprot
Q9D6Y2
resolver
uniprot_entry
ATP4B_MOUSE
resolver
uniprot_entry
Q0VBB6_MOUSE
resolver
uniprot_sec
Q9D6S3
resolver
uniprot_sec
Q9D6T2
resolver
uniprot_sec
Q9D6Y2
resolver
amino_acid_sequence
MAALQEKKSCSQRMAEFRHYCWNPDTGQMLGRTPARWVWISLYYAGFYVVMTGLFALCIYVLMQTIDPYTPDYQDQLKSPGVTLRPDVYGERGLKISYNVSENSSWAGLTHTLHSFLAGYTPASQQDSINCTSEKYFFQESFAAPNHTKFSCKFTADMLQNCSGLADPSFGFEEGKPCFIIKMNRIVKFLPSNNTAPRVDCTFQDDPQKPRKDTEPLQVEYYPPNGTFSLHYFPYYGKKAQPHYSNPLVAAKLLNVPKNMQVSIVCKILADHVTFNNPHDPYEGKVEFKLTIQK
uniprot
proteins
function
FUNCTION: The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (By similarity). {ECO:0000250|UniProtKB:P18597, ECO:0000250|UniProtKB:P19156}.
uniprot
proteins
mass_dalton
33566
uniprot
proteins
post_translational_modification
PTM: N-glycosylation is necessary for assembly and functional expression of the pump at the plasma membrane. {ECO:0000250|UniProtKB:P18597}.
uniprot
proteins
protein_family
X(+)/potassium ATPases subunit beta family
uniprot
proteins
pubmed
10764766
uniprot
proteins
pubmed
1370459
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1654563
uniprot
proteins
sequence_length
294
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P20648}; Single-pass type II membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P18597}; Single-pass type II membrane protein {ECO:0000255}. Note=Localized in the apical canalicular membrane of parietal cells. {ECO:0000250|UniProtKB:P20648}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..57; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins