Rtf2
entrez
296410
canonical
uniprot
Q3T1J8
canonical
ensembl
ENSRNOG00000005083
resolver
ensembl
ENSRNOG00055003471
resolver
ensembl
ENSRNOG00060001160
resolver
ensembl
ENSRNOG00065013980
resolver
ensp
ENSRNOP00000006884
resolver
ensp
ENSRNOP00055004003
resolver
ensp
ENSRNOP00060000861
resolver
ensp
ENSRNOP00065017972
resolver
enst
ENSRNOT00000006884
resolver
enst
ENSRNOT00055005390
resolver
enst
ENSRNOT00060001635
resolver
enst
ENSRNOT00065023084
resolver
genesymbol
Rtf2
resolver
genesymbol
Rtfdc1
resolver
genesymbol_syn
Rtfdc1
resolver
uniprot
A0A8L2Q2N4
resolver
uniprot_entry
A0A8L2Q2N4_RAT
resolver
uniprot_entry
RTF2_RAT
resolver
amino_acid_sequence
MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEVLRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKATSHIRSIKNVTELKLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEEDIIVLNGTKEDVEMLKRRMEERRLRAKLEKKTKKPKTAESASKLGISQDSAGPSKAKAGKSEEADPDPREKKSSLAPRGTASNGSASGKVGKPPCGALKRSIADSEESETYKSIFTSHSSAKRSKEESAHWVTHTSYCF
uniprot
proteins
function
FUNCTION: Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. {ECO:0000250|UniProtKB:Q9BY42}.
uniprot
proteins
mass_dalton
33812
uniprot
proteins
post_translational_modification
PTM: Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from stalled replisomes and degradation are required for genome stability. {ECO:0000250|UniProtKB:Q9BY42}.
uniprot
proteins
protein_family
Rtf2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
306
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q9BY42}. Note=Localizes at the replication fork. {ECO:0000250|UniProtKB:Q9BY42}.
uniprot
proteins