Gtpbp1
entrez
14904
canonical
uniprot
O08582
canonical
ensembl
ENSMUSG00000042535
resolver
ensp
ENSMUSP00000043575
resolver
enst
ENSMUST00000046463
resolver
genesymbol
Gtpbp1
resolver
genesymbol_syn
Gtpbp
resolver
uniprot
Q3UD96
resolver
uniprot
Q3UGW6
resolver
uniprot
Q545R1
resolver
uniprot
Q80ZY5
resolver
uniprot_entry
GTPB1_MOUSE
resolver
uniprot_sec
Q3UD96
resolver
uniprot_sec
Q3UGW6
resolver
uniprot_sec
Q545R1
resolver
uniprot_sec
Q80ZY5
resolver
amino_acid_sequence
MAAERSRSPVDSPVPASMFAPEPSSPGAARAAAAAARLHGGFDSDCSEDGEALNGEPELDLTSKLVLVSPTSEQYDSLLRQMWERMDEGCGETIYVIGQGSDGTEYGLSEADMEASYATVKSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTLLGVLTHGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSSKVITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSSERMCPIFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATVHFRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLSKREEGGPCGVPAAGGPPTGDEASSLGTAQAASTSGLQPQPKPSSGGRRRGGQRHKVKSGACVTPASGC
uniprot
proteins
ec_number
3.6.5.3
uniprot
proteins
function
FUNCTION: GTPase that plays a role in the elongation phase of protein synthesis by forming ternary complexes with GTP and aminoacyl-transfer RNAs (aa-tRNAs), and delivering aa-tRNAs to the ribosomal A site in a GTP-dependent manner. Is also able to deliver deacylated tRNA to the A site. Additionally, it is involved in RNA quality control; after GTP hydrolysis, which is not immediately followed by rapid peptide bond formation, GTPBP1 likely retains aa-tRNA in the A site and promotes exosomal degradation of faulty mRNAs engaged in 80S elongation complexes (By similarity). Plays a role in the regulation of circadian mRNA stability (By similarity). {ECO:0000250|UniProtKB:D2XV59, ECO:0000250|UniProtKB:O00178}.
uniprot
proteins
mass_dalton
72301
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
GTPBP1 subfamily
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
10938096
uniprot
proteins
pubmed
11911820
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21515746
uniprot
proteins
pubmed
9070279
uniprot
proteins
sequence_length
668
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:D2XV59}.
uniprot
proteins