Aox1
entrez
11761
canonical
uniprot
O54754
canonical
ensembl
ENSMUSG00000063558
resolver
ensp
ENSMUSP00000001027
resolver
enst
ENSMUST00000001027
resolver
genesymbol
Aox1
resolver
genesymbol_syn
Ao
resolver
genesymbol_syn
Ro
resolver
uniprot
G3X8P9
resolver
uniprot
Q9WU85
resolver
uniprot
Q9Z2Z5
resolver
uniprot_entry
AOXA_MOUSE
resolver
uniprot_entry
G3X8P9_MOUSE
resolver
uniprot_sec
Q9WU85
resolver
uniprot_sec
Q9Z2Z5
resolver
amino_acid_sequence
MDPIQLLFYVNGQKVVEKNVDPEMMLLPYLRKNLRLTGTKYGCGGGGCGACTVMISRYNPSTKAIRHHPVNACLTPICSLHGTAVTTVEGLGNTRTRLHPIQERIAKCHGTQCGFCTPGMVMSMYALLRNHPEPTLDQLTDALGGNLCRCTGYRPIIDACKTFCKASACCQSKENGVCCLDQEINGLAESQEEDKTSPELFSEEEFLPLDPTQELIFPPELMRIAEKQPPKTRVFYGERVTWISPVTLKELVEAKFKYPQAPIVMGYTSVGPEVKFKGVFHPIIISPDRIEELGVISQARDGLTLGAGLSLDQVKDILADIVQKLPEEKTQTYRALLKHLRTLAGSQIRNMASLGGHIVSRHLDSDLNPLLAVGNCTLNLLSKDGERRIPLSEEFLRKCPEADLKPQEVLVSVNIPWSRKWEFVSAFRQAQRQQNALAIVNSGMRVLFREGGGVIEELSILYGGVGSTIISAKNSCQRLIGRPWNEGMLDTRCRLVLDEVTLAASAPGGKVEFKRTLIISFLFKFYLEVSQGLKREDPGHSPSLAGNHESALDDLHSKHPWRTLTHQNVDPAQLPQDPIGRPIMHLSGIKHATGEAIYCDDMPAVDRELFLTFVTSSRAHAKIVSIDLSEALSLPGVVDIITADHLQEANTFGTETFLATDEVHCVGHLVCAVIADSETRAKQAAKQVKVVYQDLAPLILTIEEAIQHKSFFKSERKLECGNVDEAFKIVDQILEGEIHIGGQEHFYMETQSMLVVPKGEDGEIDIYVSTQFPKYIQDIVAATLKLSANKVMCHVRRVGGAFGGKVGKTSILAAITAFAASKHGRAVRCILERGEDMLITGGRHPYLGKYKAGFMNEGRILALDVEHYCNGGCSLDESLWVIEMGLLKLDNAYKFPNLRCRGWACRTNLPSNTALRGFGFPQAGLVTEACITEVAIKCGLSPEQVRTINMYKHVDTTHYKQEFSAKALSECWRECMAKCSYFERKAAIGKFNAENSWKKRGMAVIPLKFPVGIGSVAMGQAAALVHIYLDGSALVSHGGIEMGQGVHTKMIQVVSRELRMPMSSVHLRGTSTETVPNTNASGGSVVADLNGLAVKDACQTLLKRLEPIISKNPQGTWKDWAQTAFDQSISLSAVGYFRGYESNIDWEKGEGHPFEYFVFGAACSEVEINCLTGDHKNIRTNIVMDVGHSINPALDIGQVEGAFIQGMGLYTIEELSYSPQGTLYSRGPNQYKIPAICDIPTEMHISFLPPSEHSNTLYSSKGLGESGVFLGCSVFFAIHDAVKAARQERGISGPWKLNSPLTPEKIRMACEDKFTKMIPRDEPGSYVPCNIPV
uniprot
proteins
ec_number
1.17.3.-
uniprot
proteins
ec_number
1.2.3.1
uniprot
proteins
ec_number
1.2.3.8
uniprot
proteins
ec_number
1.2.3.9
uniprot
proteins
function
FUNCTION: Primarily catalyzes oxidation reactions of a broad range of drug and xenobiotic substrates and participates in their metabolism through oxidative biotransformation (PubMed:10190983, PubMed:10377246, PubMed:19401776, PubMed:23462233, PubMed:4256441). Oxidizes at least three structural types of substrates: aldehydes such as benzaldehyde, retinal, pyridoxal, and vanillin; aromatic azaheterocyclic compounds such as phthalazine, quinazoline and phenanthridine; and quaternary azaheterocyclic compounds such as 1-methylnicotinamide and nicotine imine (PubMed:10190983, PubMed:10377246, PubMed:19401776, PubMed:23462233, PubMed:4256441). Converts aldehydes to carboxylic acids, aromatic and quaternary azaheterocyclic compounds to lactams, typically by using molecular oxygen as the terminal electron acceptor and producing hydrogen peroxide as a by-product (PubMed:10190983, PubMed:10377246, PubMed:19401776, PubMed:23462233, PubMed:4256441). Under some conditions, especially with electron-deficient substrates or limited oxygen, can also catalyze reduction reactions using N-methylnicotinamide, 2-hydroxypyrimidine or benzaldehyde as electron donor substrate (PubMed:15720138, PubMed:23462233). These reductive activities include N-O bond reductions in nitro groups (e.g., imidacloprid, IMI), hydroxamic acids, and oxazoles (e.g., zonisamide), as well as N-S bond reductions of sulfoxides (e.g., sulindac) (By similarity). {ECO:0000250|UniProtKB:Q5FB27, ECO:0000269|PubMed:10190983, ECO:0000269|PubMed:10377246, ECO:0000269|PubMed:15720138, ECO:0000269|PubMed:19401776, ECO:0000269|PubMed:23462233, ECO:0000269|PubMed:4256441}.
uniprot
proteins
mass_dalton
146678
uniprot
proteins
mutagenesis
MUTAGEN 806; /note="V->E: Decreases substrate affinity and activity on benzaldehyde, phthalazine and acetaldehyde, while increases affinity for more hydrophobic aldehydes like retinal. Abolishes catalytic activity; when associated with R-884."; /evidence="ECO:0000269|PubMed:19401776"; MUTAGEN 884; /note="M->R: Abolishes catalytic activity on phthalazine and acetaldehyde. Decreases catalytic efficiency on benzaldehyde and retinal. Abolishes catalytic activity; when associated with E-806."; /evidence="ECO:0000269|PubMed:19401776"; MUTAGEN 1265; /note="E->Q: Abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:19401776
uniprot
proteins
protein_family
Xanthine dehydrogenase family
uniprot
proteins
pubmed
10190983
uniprot
proteins
pubmed
10377246
uniprot
proteins
pubmed
10673024
uniprot
proteins
pubmed
15720138
uniprot
proteins
pubmed
18671973
uniprot
proteins
pubmed
19401776
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23263164
uniprot
proteins
pubmed
23462233
uniprot
proteins
pubmed
4256441
uniprot
proteins
pubmed
9243637
uniprot
proteins
sequence_length
1333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10377246}.
uniprot
proteins