Cdc42bpg
entrez
240505
canonical
uniprot
Q80UW5
canonical
ensembl
ENSMUSG00000024769
resolver
ensp
ENSMUSP00000025681
resolver
enst
ENSMUST00000025681
resolver
genesymbol
Cdc42bpg
resolver
uniprot_entry
MRCKG_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25}.
uniprot
proteins
amino_acid_sequence
MEQRLRALEQLVRGEAGGSPGLDGLLDLLLGVHQELSSAPLRRERNVAQFLSWASPFVTKVKELRLQRDDFEILKVIGRGAFGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDMNGHIRLADFGSCLRLNNNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPADVTDVPASAQDLIRQLLCRQEERLGRGGLDDFRKHPFFEGVDWERLATSTAPYIPELRGPMDTSNFDVDDDTLNRPETLPPSSHGAFSGHHLPFVGFTYTSGSPFDVQSSELMAAPEGTPHCVEQVKVELSHKCQEPLHGPLQPQELVRLQKEVQVLQEKLAETLRDSKASLSQTDGLHARSPAPNIQLQQEKDRLQQELTEAQAALRVQDAELCQAQNRQEEFLQRLWEAQEREAAAASQIQALNSQLEEAWVVRRELEGQVTTLSQEVTRLQGQCKQESSQAKTVHAAPETNGIGSPEGQSQEAQLRKEVAALREQLEHACSQGISVGKEEVLCRLQEENQRLSREQERLAGELELELQSKQRLEGERRETESNWEAQIADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPTRPLDHQWKARRLQKMEASARLELQSALEAEIRAKQSLQEQLTQVQEAQRQAERRLQEAEKQSQALQQEVAELREELQARGPGDARPSTSLIPLLSFWNTEKDSAKDPGNSGEGPRSGAEAELRPEGRRSLRMGSVFPRVPAATTTPAEGPPAKPGSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDTCGYFCHSACASQAPPCPVPPELLRTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVYAALSDSRLLLFDAPDPRGSLASGVLLQALDLRDPQFSATPVLAPDVIHAQSKDLPRIFRVTASQLTVPPTTCTVLLLAENEGERERWLQVLGELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHALCAAVIDQERLALGTEEGLFVIHLHSNDIFQVGDCRRVQRLAVSSAAGLLAVLCGRGPSVRLFALDELESAEVAGAKIPESRGCQALVAGRILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPAPVQSLGLLGDRLCVGAAGTFALYPLLNEAAPLALGTGLVAEELPASRGGLGEALGAVELSLSELLLLFATAGVYVDSAGRKSRSHELLWPAAPTGWGYTAPYLTVFSENALDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRNPLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSDELRQQQRREMLKDPFVRSKFISPPTNFNHLVHVGPTEGRPNTRDGTRAQEQKSRGARSSGPQRPHSFSEAFRRPVSTGSDGLPGETDPLVKRKPWTSLSSESVSCPQGSLSPAASLIQVSERPRSLPPDPESESSP
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25}.
uniprot
proteins
mass_dalton
172147
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
DMPK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1551
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Concentrates at the leading edge of cells. {ECO:0000250}.
uniprot
proteins