MOAP1
entrez
64112
canonical
uniprot
Q96BY2
canonical
ensembl
ENSG00000165943
resolver
ensembl
ENSG00000278268
resolver
ensp
ENSP00000298894
resolver
ensp
ENSP00000451594
resolver
ensp
ENSP00000482284
resolver
ensp
ENSP00000486260
resolver
ensp
ENSP00000535661
resolver
ensp
ENSP00000535662
resolver
ensp
ENSP00000535663
resolver
enst
ENST00000298894
resolver
enst
ENST00000556883
resolver
enst
ENST00000616515
resolver
enst
ENST00000627896
resolver
enst
ENST00000865602
resolver
enst
ENST00000865603
resolver
enst
ENST00000865604
resolver
genesymbol
MOAP1
resolver
genesymbol_syn
PNMA4
resolver
hgnc
HGNC:16658
resolver
uniprot
B2RDF6
resolver
uniprot
Q9H833
resolver
uniprot
Q9HAS1
resolver
uniprot_entry
MOAP1_HUMAN
resolver
uniprot_sec
B2RDF6
resolver
uniprot_sec
Q9H833
resolver
uniprot_sec
Q9HAS1
resolver
amino_acid_sequence
MTLRLLEDWCRGMDMNPRKALLIAGISQSCSVAEIEEALQAGLAPLGEYRLLGRMFRRDENRKVALVGLTAETSHALVPKEIPGKGGIWRVIFKPPDPDNTFLSRLNEFLAGEGMTVGELSRALGHENGSLDPEQGMIPEMWAPMLAQALEALQPALQCLKYKKLRVFSGRESPEPGEEEFGRWMFHTTQMIKAWQVPDVEKRRRLLESLRGPALDVIRVLKINNPLITVDECLQALEEVFGVTDNPRELQVKYLTTYQKDEEKLSAYVLRLEPLLQKLVQRGAIERDAVNQARLDQVIAGAVHKTIRRELNLPEDGPAPGFLQLLVLIKDYEAAEEEEALLQAILEGNFT
uniprot
proteins
function
FUNCTION: Retrotransposon-derived protein that forms virion-like capsids (By similarity). Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis (PubMed:11060313, PubMed:16199525). Required for death receptor-dependent apoptosis (PubMed:11060313). When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (PubMed:15949439). Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins (PubMed:33783314). Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex (PubMed:33393215). {ECO:0000250|UniProtKB:Q9ERH6, ECO:0000269|PubMed:11060313, ECO:0000269|PubMed:15949439, ECO:0000269|PubMed:16199525, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33783314}.
uniprot
proteins
mass_dalton
39513
uniprot
proteins
mutagenesis
MUTAGEN 49..52; /note="YRLL->ARLA: Abolished interaction with ATG8 proteins MAP1LC3A, MAP1LC3B and MAP1LC3C."; /evidence="ECO:0000269|PubMed:33783314"; MUTAGEN 89..92; /note="WRVI->ARVA: Does not affect interaction with ATG8 proteins MAP1LC3A, MAP1LC3B and MAP1LC3C."; /evidence="ECO:0000269|PubMed:33783314"; MUTAGEN 120..127; /note="Missing: Abrogates interaction with BAX, resulting in a nonapoptotic protein."; /evidence="ECO:0000269|PubMed:11060313"; MUTAGEN 120; /note="L->E: Weakened interaction with BAX, resulting in a nonapoptotic protein."; /evidence="ECO:0000269|PubMed:11060313"; MUTAGEN 125..127; /note="GHE->VLA: Abrogates interaction with BAX, resulting in a nonapoptotic protein."; /evidence="ECO:0000269|PubMed:11060313"; MUTAGEN 161..166; /note="KYKKLR->AYAALA: No effect on RASSF1-binding."; /evidence="ECO:0000269|PubMed:15949439"; MUTAGEN 162..165; /note="YKKL->AKKA: Does not affect interaction with ATG8 proteins MAP1LC3A, MAP1LC3B and MAP1LC3C."; /evidence="ECO:0000269|PubMed:33783314"; MUTAGEN 178..180; /note="EEE->AAA: No effect on RASSF1-binding; interacts with BAX in the absence of RASSF1."; MUTAGEN 202..205; /note="KRRR->AAAA: Loss of RASSF1-binding; interacts with BAX in the absence of RASSF1."; /evidence="ECO:0000269|PubMed:15949439
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39. {ECO:0000269|PubMed:22529100}.
uniprot
proteins
protein_family
PNMA family
uniprot
proteins
pubmed
11060313
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15949439
uniprot
proteins
pubmed
16199525
uniprot
proteins
pubmed
19100260
uniprot
proteins
pubmed
19366867
uniprot
proteins
pubmed
22529100
uniprot
proteins
pubmed
33393215
uniprot
proteins
pubmed
33783314
uniprot
proteins
pubmed
34357660
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19100260}. Mitochondrion outer membrane {ECO:0000269|PubMed:16199525}. Extracellular vesicle membrane {ECO:0000250|UniProtKB:Q9ERH6}. Note=Forms virion-like extracellular vesicles that are released from cells. {ECO:0000250|UniProtKB:Q9ERH6}.
uniprot
proteins