Rab12
entrez
19328
canonical
uniprot
P35283
canonical
ensembl
ENSMUSG00000023460
resolver
ensp
ENSMUSP00000070134
resolver
enst
ENSMUST00000070538
resolver
genesymbol
Rab12
resolver
uniprot
A2CG35
resolver
uniprot
Q0PD43
resolver
uniprot
Q9CUW7
resolver
uniprot_entry
A2CG35_MOUSE
resolver
uniprot_entry
RAB12_MOUSE
resolver
uniprot_sec
Q0PD43
resolver
uniprot_sec
Q9CUW7
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including DENND3 which promote the exchange of bound GDP for free GTP (PubMed:21718402). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000269|PubMed:21718402, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MLLPLLRRSCFPSSTPGGGGGGGSAERVEGARGPGARGRRPEREPYACMDPSAALHRRPAGGSLGAVSPALSGGQARRRKQPPRPADFKLQVIIIGSRGVGKTSLMERFTDDTFCEACKSTVGVDFKIKTVELRGKKIRLQIWDTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCETDREISRQQGEKFAQQITGMRFCEASAKDNFNVDEIFLKLVDDILKKMPLDVLRNELSNSILSLQPEPEIPPELPPPRPHVRCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB12 may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor (PubMed:21718402). Involved in autophagy (PubMed:23357852). {ECO:0000250|UniProtKB:P61026, ECO:0000269|PubMed:21718402, ECO:0000269|PubMed:23357852}.
uniprot
proteins
mass_dalton
32238
uniprot
proteins
mutagenesis
MUTAGEN 148; /note="Q->L: Probable constitutively active mutant unable to hydrolyze GTP; increases degradation of the transferrin receptor."; /evidence="ECO:0000269|PubMed:21718402
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-153 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2. {ECO:0000250|UniProtKB:Q6IQ22}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
1555775
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16923123
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21718402
uniprot
proteins
pubmed
23357852
uniprot
proteins
pubmed
26824392
uniprot
proteins
pubmed
29125462
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:21718402}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:21718402}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P51152}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:23357852}.
uniprot
proteins