TMEM87A
entrez
25963
canonical
uniprot
Q8NBN3
canonical
ensembl
ENSG00000103978
resolver
ensp
ENSP00000305894
resolver
ensp
ENSP00000374484
resolver
ensp
ENSP00000457308
resolver
ensp
ENSP00000516026
resolver
ensp
ENSP00000516027
resolver
ensp
ENSP00000547025
resolver
ensp
ENSP00000547026
resolver
ensp
ENSP00000547028
resolver
ensp
ENSP00000623510
resolver
ensp
ENSP00000623512
resolver
ensp
ENSP00000623513
resolver
ensp
ENSP00000676899
resolver
ensp
ENSP00000711091
resolver
ensp
ENSP00000759368
resolver
enst
ENST00000566014
resolver
enst
ENST00000704760
resolver
enst
ENST00000704761
resolver
genesymbol
TMEM87A
resolver
genesymbol_syn
GOLPHCAT
resolver
hgnc
HGNC:24522
resolver
uniprot
A0A994J4W5
resolver
uniprot
A0A994J7M5
resolver
uniprot
H3BTS6
resolver
uniprot
Q6NT77
resolver
uniprot
Q8NCA4
resolver
uniprot
Q9BS46
resolver
uniprot
Q9P103
resolver
uniprot
Q9Y3Y7
resolver
uniprot_entry
A0A994J4W5_HUMAN
resolver
uniprot_entry
A0A994J7M5_HUMAN
resolver
uniprot_entry
GPHCC_HUMAN
resolver
uniprot_entry
H3BTS6_HUMAN
resolver
uniprot_sec
Q6NT77
resolver
uniprot_sec
Q8NCA4
resolver
uniprot_sec
Q9BS46
resolver
uniprot_sec
Q9P103
resolver
uniprot_sec
Q9Y3Y7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by gluconate. {ECO:0000269|PubMed:38992057}.
uniprot
proteins
amino_acid_sequence
MAAAAWLQVLPVILLLLGAHPSPLSFFSAGPATVAAADRSKWHIPIPSGKNYFSFGKILFRNTTIFLKFDGEPCDLSLNITWYLKSADCYNEIYNFKAEEVELYLEKLKEKRGLSGKYQTSSKLFQNCSELFKTQTFSGDFMHRLPLLGEKQEAKENGTNLTFIGDKTAMHEPLQTWQDAPYIFIVHIGISSSKESSKENSLSNLFTMTVEVKGPYEYLTLEDYPLMIFFMVMCIVYVLFGVLWLAWSACYWRDLLRIQFWIGAVIFLGMLEKAVFYAEFQNIRYKGESVQGALILAELLSAVKRSLARTLVIIVSLGYGIVKPRLGVTLHKVVVAGALYLLFSGMEGVLRVTGAQTDLASLAFIPLAFLDTALCWWIFISLTQTMKLLKLRRNIVKLSLYRHFTNTLILAVAASIVFIIWTTMKFRIVTCQSDWRELWVDDAIWRLLFSMILFVIMVLWRPSANNQRFAFSPLSEEEEEDEQKEPMLKESFEGMKMRSTKQEPNGNSKVNKAQEDDLKWVEENVPSSVTDVALPALLDSDEERMITHFERSKME
uniprot
proteins
function
FUNCTION: Voltage- and pH-dependent, inwardly rectifying cation channel that mediates ion flux across the Golgi membrane, supporting luminal acidification necessary for normal Golgi morphology and function (PubMed:38992057). Implicated in normal touch sensitivity through the generation of mechanically activated currents (PubMed:32228863, PubMed:38422143). Could also be involved in cell mechanosensitivity regulating cell adhesion and migration (PubMed:32228863). May also be involved in retrograde transport from endosomes to the trans-Golgi network (TGN) (PubMed:26157166). Contributes to hippocampal spatial and contextual memory by maintaining Golgi function and structural integrity in hippocampal neurons (By similarity). {ECO:0000250|UniProtKB:Q8BXN9, ECO:0000269|PubMed:26157166, ECO:0000269|PubMed:32228863, ECO:0000269|PubMed:38422143}.
uniprot
proteins
mass_dalton
63430
uniprot
proteins
mutagenesis
MUTAGEN 237; /note="Y->A: Significant decrease in channel activity. No effect on plasma membrane localization."; /evidence="ECO:0000269|PubMed:38992057"; MUTAGEN 271; /note="L->F: Reduced mechanosensitive channel activity in Tmem87a-expressing cells."; /evidence="ECO:0000269|PubMed:32228863"; MUTAGEN 272; /note="E->A: Significant decrease in channel activity. No effect on plasma membrane localization."; /evidence="ECO:0000269|PubMed:38992057"; MUTAGEN 273; /note="K->A: Significant decrease in channel activity. No effect on plasma membrane localization."; /evidence="ECO:0000269|PubMed:38992057"; MUTAGEN 279; /note="E->A: Loss of channel activity. No effect on plasma membrane localization."; /evidence="ECO:0000269|PubMed:38992057"; MUTAGEN 288; /note="E->R: Increase in channel activity."; /evidence="ECO:0000269|PubMed:38992057"; MUTAGEN 292; /note="G->N: Reduced mechanosensitive channel activity in Tmem87a-expressing cells."; /evidence="ECO:0000269|PubMed:32228863"; MUTAGEN 298; /note="E->A: Partial loss of channel activity. No effect on plasma membrane localization."; /evidence="ECO:0000269|PubMed:38992057"; MUTAGEN 301; /note="S->A: Significant decrease in channel activity. No effect on plasma membrane localization."; /evidence="ECO:0000269|PubMed:38992057"; MUTAGEN 304; /note="K->A: Significant decrease in channel activity. No effect on plasma membrane localization."; /evidence="ECO:0000269|PubMed:38992057"; MUTAGEN 305; /note="R->A: Significant decrease in channel activity. No effect on plasma membrane localization."; /evidence="ECO:0000269|PubMed:38992057"; MUTAGEN 308; /note="A->M: Partial loss of channel activity."; /evidence="ECO:0000269|PubMed:38992057"; MUTAGEN 309; /note="R->A: Significant decrease in channel activity. No effect on plasma membrane localization."; /evidence="ECO:0000269|PubMed:38992057"; MUTAGEN 318..320; /note="GYG->AAA: Loss of channel activity. No effect on plasma membrane localization."; /evidence="ECO:0000269|PubMed:38992057
uniprot
proteins
protein_family
LU7TM family
uniprot
proteins
protein_family
TMEM87 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26157166
uniprot
proteins
pubmed
32228863
uniprot
proteins
pubmed
36373655
uniprot
proteins
pubmed
38422143
uniprot
proteins
pubmed
38992057
uniprot
proteins
sequence_length
555
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:32228863, ECO:0000269|PubMed:38992057}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:26157166, ECO:0000269|PubMed:32228863, ECO:0000269|PubMed:38992057}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:32228863}; Multi-pass membrane protein {ECO:0000255}. Cell projection, ruffle {ECO:0000269|PubMed:32228863}.
uniprot
proteins
transmembrane_region
TRANSMEM 226..246; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 306..322; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 326..346; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 404..424; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 438..458; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins