PLA2G5
entrez
5322
canonical
uniprot
P39877
canonical
ensembl
ENSG00000127472
resolver
ensp
ENSP00000364249
resolver
ensp
ENSP00000564132
resolver
ensp
ENSP00000564133
resolver
ensp
ENSP00000564134
resolver
ensp
ENSP00000564135
resolver
ensp
ENSP00000564136
resolver
ensp
ENSP00000564137
resolver
ensp
ENSP00000564138
resolver
ensp
ENSP00000564139
resolver
ensp
ENSP00000564140
resolver
ensp
ENSP00000564141
resolver
ensp
ENSP00000564142
resolver
ensp
ENSP00000564143
resolver
ensp
ENSP00000564144
resolver
ensp
ENSP00000564145
resolver
ensp
ENSP00000564146
resolver
ensp
ENSP00000564147
resolver
ensp
ENSP00000564148
resolver
ensp
ENSP00000564149
resolver
ensp
ENSP00000564150
resolver
ensp
ENSP00000564151
resolver
ensp
ENSP00000564152
resolver
ensp
ENSP00000564153
resolver
ensp
ENSP00000564154
resolver
ensp
ENSP00000564155
resolver
ensp
ENSP00000632214
resolver
ensp
ENSP00000632215
resolver
ensp
ENSP00000632216
resolver
ensp
ENSP00000632217
resolver
ensp
ENSP00000632218
resolver
ensp
ENSP00000632219
resolver
ensp
ENSP00000632221
resolver
ensp
ENSP00000632222
resolver
ensp
ENSP00000632223
resolver
ensp
ENSP00000632224
resolver
ensp
ENSP00000632225
resolver
ensp
ENSP00000632226
resolver
ensp
ENSP00000632227
resolver
ensp
ENSP00000632228
resolver
ensp
ENSP00000632229
resolver
ensp
ENSP00000632230
resolver
ensp
ENSP00000632231
resolver
ensp
ENSP00000632232
resolver
ensp
ENSP00000632233
resolver
ensp
ENSP00000632234
resolver
ensp
ENSP00000632235
resolver
ensp
ENSP00000632236
resolver
ensp
ENSP00000632237
resolver
enst
ENST00000375108
resolver
enst
ENST00000894073
resolver
enst
ENST00000894074
resolver
enst
ENST00000894075
resolver
enst
ENST00000894076
resolver
enst
ENST00000894077
resolver
enst
ENST00000894078
resolver
enst
ENST00000894079
resolver
enst
ENST00000894080
resolver
enst
ENST00000894081
resolver
enst
ENST00000894082
resolver
enst
ENST00000894083
resolver
enst
ENST00000894084
resolver
enst
ENST00000894085
resolver
enst
ENST00000894086
resolver
enst
ENST00000894087
resolver
enst
ENST00000894088
resolver
enst
ENST00000894089
resolver
enst
ENST00000894090
resolver
enst
ENST00000894091
resolver
enst
ENST00000894092
resolver
enst
ENST00000894093
resolver
enst
ENST00000894094
resolver
enst
ENST00000894095
resolver
enst
ENST00000894096
resolver
enst
ENST00000962155
resolver
enst
ENST00000962156
resolver
enst
ENST00000962157
resolver
enst
ENST00000962158
resolver
enst
ENST00000962159
resolver
enst
ENST00000962160
resolver
enst
ENST00000962162
resolver
enst
ENST00000962163
resolver
enst
ENST00000962164
resolver
enst
ENST00000962165
resolver
enst
ENST00000962166
resolver
enst
ENST00000962167
resolver
enst
ENST00000962168
resolver
enst
ENST00000962169
resolver
enst
ENST00000962170
resolver
enst
ENST00000962171
resolver
enst
ENST00000962172
resolver
enst
ENST00000962173
resolver
enst
ENST00000962174
resolver
enst
ENST00000962175
resolver
enst
ENST00000962176
resolver
enst
ENST00000962177
resolver
enst
ENST00000962178
resolver
genesymbol
PLA2G5
resolver
hgnc
HGNC:9038
resolver
uniprot
Q8N435
resolver
uniprot_entry
PA2G5_HUMAN
resolver
uniprot_sec
Q8N435
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cardiolipin. {ECO:0000269|PubMed:23533611}.
uniprot
proteins
amino_acid_sequence
MKGLLPLAWFLACSVPAVQGGLLDLKSMIEKVTGKNALTNYGFYGCYCGWGGRGTPKDGTDWCCWAHDHCYGRLEEKGCNIRTQSYKYRFAWGVVTCEPGPFCHVNLCACDRKLVYCLKRNLRSYNPQYQYFPNILCS
uniprot
proteins
disease_involvement
DISEASE: Fleck retina, familial benign (FRFB) [MIM:228980]: An autosomal recessive condition associated with a distinctive retinal appearance and no apparent visual or electrophysiologic deficits. Affected individuals are asymptomatic, but fundus examination reveals a striking pattern of diffuse, yellow-white, fleck-like lesions extending to the far periphery of the retina but sparing the foveal region. {ECO:0000269|PubMed:22137173, ECO:0000269|PubMed:25549071}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:8300559). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups (PubMed:14998370, PubMed:23533611, PubMed:8300559). Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype (By similarity). May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of cardiolipin, a major component of the inner membrane of mitochondria and bacterial membranes (PubMed:23533611). Promotes phagocytosis of bacteria in macrophages through production of lysophosphatidylethanolamines (PubMed:25725101). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). Promotes phagocytosis and killing of ingested fungi likely through controlling phagosome-lysosome fusion and phagosome maturation (By similarity). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells (PubMed:12124392, PubMed:12796497). In eosinophils, triggers perinuclear arachidonate release and LTC4 synthesis in a PLA2G4A-independent way (PubMed:12796497). In neutrophils, amplifies CysLTs biosynthesis initiated by PLA2G4A (PubMed:12124392). Promotes immune complex clearance in macrophages via stimulating synthesis of CysLTs, which act through CYSLTR1 to trigger phagocytosis (By similarity). May regulate antigen processing in antigen-presenting cells (By similarity). In pulmonary macrophages regulates IL33 production required for activation of group 2 innate lymphoid cells (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (PubMed:14998370). {ECO:0000250|UniProtKB:P97391, ECO:0000269|PubMed:11694541, ECO:0000269|PubMed:12124392, ECO:0000269|PubMed:12796497, ECO:0000269|PubMed:14998370, ECO:0000269|PubMed:23533611, ECO:0000269|PubMed:25725101, ECO:0000269|PubMed:8300559}.
uniprot
proteins
mass_dalton
15674
uniprot
proteins
mutagenesis
MUTAGEN 50; /note="W->A: Impairs arachidonate release from cell membranes."; /evidence="ECO:0000269|PubMed:12796497"; MUTAGEN 112; /note="R->E: Decreases arachidonate release from cell membranes; when associated with E-113."; /evidence="ECO:0000269|PubMed:12796497"; MUTAGEN 113; /note="K->E: Decreases arachidonate release from cell membranes; when associated with E-112."; /evidence="ECO:0000269|PubMed:12796497
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000269|PubMed:25725101}.; PATHWAY: Lipid metabolism; leukotriene B4 biosynthesis. {ECO:0000269|PubMed:12124392}.; PATHWAY: Lipid metabolism; leukotriene C4 biosynthesis. {ECO:0000269|PubMed:12796497}.
uniprot
proteins
post_translational_modification
PTM: This enzyme lacks one of the seven disulfide bonds found in similar PLA2 proteins.
uniprot
proteins
protein_family
Phospholipase A2 family
uniprot
proteins
pubmed
11694541
uniprot
proteins
pubmed
12124392
uniprot
proteins
pubmed
12796497
uniprot
proteins
pubmed
14998370
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
22137173
uniprot
proteins
pubmed
23533611
uniprot
proteins
pubmed
25549071
uniprot
proteins
pubmed
25725101
uniprot
proteins
pubmed
8300559
uniprot
proteins
sequence_length
138
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8300559}. Cell membrane {ECO:0000250|UniProtKB:P97391}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P97391}. Recycling endosome {ECO:0000250|UniProtKB:P97391}. Golgi apparatus, cis-Golgi network {ECO:0000250|UniProtKB:P97391}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P97391}.
uniprot
proteins