Cdca7l
entrez
217946
canonical
uniprot
Q922M5
canonical
ensembl
ENSMUSG00000021175
resolver
ensp
ENSMUSP00000021592
resolver
ensp
ENSMUSP00000293916
resolver
ensp
ENSMUSP00000293917
resolver
enst
ENSMUST00000021592
resolver
genesymbol
Cdca7l
resolver
uniprot_entry
CDA7L_MOUSE
resolver
amino_acid_sequence
MELATRSQIPKEVADIFSAPSDDEEFVGFQDDVPMQNLSESCGSLDSRELEKQQNVCFRSKYFTEELRRIFKEDTDSEMEDFEGFTESELNMSSNPELMESELSDSDKAYPVMNDAEEDDEEEAAPRRGRSTRRSSFGLRVAFQFPTKKLARTPDKDSSHLLDSKTDLRRKKSSRQPKGKEDSASDAEDESRAESQENSDALLKRAMNIKENKAMLAQLLAELNSVPDFFPVRTPPSASRRRTPRRAFSEGQITRRMNPTRSARPPEKFALENFTFSATKLTEELYSFRRRKTISGGKCQTYRRHRISSFRSVKDITEEDLENIAITVRDKVYDKVLGNTCHQCRQKTIDTKTVCRNQSCGGVRGQFCGPCLRNRYGEDVRTALLDPKWTCPPCRGICNCSYCRRRDGRCATGILIHLAKFYGYDNVKEYLESLQKQL
uniprot
proteins
function
FUNCTION: Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells (By similarity). Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. {ECO:0000250, ECO:0000269|PubMed:16829576}.
uniprot
proteins
mass_dalton
50248
uniprot
proteins
post_translational_modification
PTM: Phosphorylation increases its interaction with PSIP1. {ECO:0000250|UniProtKB:Q96GN5}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15994933
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16829576
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
438
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction (By similarity). {ECO:0000250}.
uniprot
proteins