Pllp
entrez
67801
canonical
uniprot
Q9DCU2
canonical
ensembl
ENSMUSG00000031775
resolver
ensp
ENSMUSP00000034227
resolver
enst
ENSMUST00000034227
resolver
genesymbol
Pllp
resolver
genesymbol_syn
Plapi
resolver
genesymbol_syn
Pmlp
resolver
genesymbol_syn
Tm4sf11
resolver
uniprot
Q544Q5
resolver
uniprot_entry
PLLP_MOUSE
resolver
uniprot_sec
Q544Q5
resolver
amino_acid_sequence
MAEFPSKVSTRTSSPAQGVGASVSALRPDLGFVRSALGVLALLQLALGLLVWALIADTPYHLYPAYGWVMFVAVFLWLVTIVFFIIYLFQLHMKLYMVPWPLVLLIFFVAATVLYITAFIACAAAVDLTSLRGSRPYNQRSAASFFACLVMIAYGVSAFFSFQAWRGVGSNAATSQMAGGYS
uniprot
proteins
function
FUNCTION: Main component of the myelin sheath that plays an important role in myelin membrane biogenesis and myelination (By similarity). Plays an essential function in apical endocytosis. Regulates epithelial development through the regulation of apical endocytosis (By similarity). Part of the intracellular machinery that mediates basolateral-to-apical transport of ICAM-1, an essential adhesion receptor in epithelial cells, from the subapical compartment in hepatic epithelial cells (By similarity). {ECO:0000250|UniProtKB:A3KQ86, ECO:0000250|UniProtKB:Q9Y342}.
uniprot
proteins
mass_dalton
19801
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:P47987}.
uniprot
proteins
protein_family
MAL family
uniprot
proteins
pubmed
11707781
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26002055
uniprot
proteins
sequence_length
182
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11707781}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9Y342}; Multi-pass membrane protein {ECO:0000255}. Myelin membrane {ECO:0000250|UniProtKB:P47987}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:P47987}; Multi-pass membrane protein {ECO:0000255}. Note=In polarized cells, localized predominantly in the apical membrane (By similarity). Located in lipid raft (By similarity). Recycled between the plasma membrane and the Golgi complex (PubMed:26002055). PLLP is continuously recirculating in the cell (PubMed:26002055). {ECO:0000250|UniProtKB:A3KQ86, ECO:0000250|UniProtKB:P47987, ECO:0000269|PubMed:26002055}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins