Insc
entrez
233752
canonical
uniprot
Q3HNM7
canonical
ensembl
ENSMUSG00000048782
resolver
ensp
ENSMUSP00000112682
resolver
ensp
ENSMUSP00000119459
resolver
ensp
ENSMUSP00000125061
resolver
ensp
ENSMUSP00000250252
resolver
enst
ENSMUST00000117543
resolver
enst
ENSMUST00000136645
resolver
genesymbol
Insc
resolver
uniprot
B2RTA5
resolver
uniprot
D3Z267
resolver
uniprot
G3UW77
resolver
uniprot
Q8C7I7
resolver
uniprot_entry
D3Z267_MOUSE
resolver
uniprot_entry
INSC_MOUSE
resolver
uniprot_sec
B2RTA5
resolver
uniprot_sec
G3UW77
resolver
uniprot_sec
Q8C7I7
resolver
amino_acid_sequence
MRRPPGDGDSTGEGPGNWGLWGAQESRRLCCVGPDRCGQALLQIGINMMALPGGRHLDSVPLQEQRLHFMQVDSVQRWMEDLKLMTECECMCVLQAKPISLEEDTQGDLILAGGPGPGDPLQLLLKRGWVISTELRRIGQKLAQDRWARVHSMSVRLTCHARSMVSEYSTISRTASQEMGQAEKLLMEKCSELSAVTERCLQVENEHVLKSMKACVSETLSLLGEHFGQLLELALTREVQALVRKIDTSDNIYITESTTGNLFGLTQEGAPLCRIIAKEGGVVALFKVCRQDSFRCLYPQALRTLASICCVEEGVHQLEKVDGILCLADILTDESHSEATRAEAAAVVAQVTSPHLSFTQHLTSFLENMEEIVTALIKLCQEASSGEVFLLASAALANITFFDKMACEMLLQLNAIRVLLEACGDKQRVDTPYTRDQIVTILANMSVLEQCGSDIIQENGVQLIMGMLSEKPRSGTPAEVAACERVQQKAAVTLARLCRDPDVAQEAVRLSCMSRLIELCRSPSERNSSDAVLVACLAALRRLAGVCPEGLQDSDFQQLVQPRLVDSFLLCSNMEESFV
uniprot
proteins
function
FUNCTION: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis (PubMed:16301171, PubMed:21816348). May regulate cell proliferation and differentiation in the developing nervous system (PubMed:16301171). May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (PubMed:16094321). {ECO:0000269|PubMed:16094321, ECO:0000269|PubMed:16301171, ECO:0000269|PubMed:21816348}.
uniprot
proteins
mass_dalton
63615
uniprot
proteins
mutagenesis
MUTAGEN 74; /note="S->E: Abolishes interaction with GPSM2."; /evidence="ECO:0000269|PubMed:21816348"; MUTAGEN 78; /note="W->E: Abolishes interaction with GPSM2."; /evidence="ECO:0000269|PubMed:21816348"; MUTAGEN 79; /note="M->E: Abolishes interaction with GPSM2."; /evidence="ECO:0000269|PubMed:21816348"; MUTAGEN 82; /note="L->E: Abolishes interaction with GPSM2."; /evidence="ECO:0000269|PubMed:21816348
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16094321
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16301171
uniprot
proteins
pubmed
21816348
uniprot
proteins
sequence_length
579
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16094321, ECO:0000269|PubMed:16301171, ECO:0000269|PubMed:21816348}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q1MX18}. Note=Uniformly distributed in the cytoplasm during interphase. During metaphase, detected in the cell cortex, adjacent to the mitotic spindle poles. {ECO:0000250|UniProtKB:Q1MX18}.
uniprot
proteins