LYVE1
entrez
10894
canonical
uniprot
Q9Y5Y7
canonical
ensembl
ENSG00000133800
resolver
ensp
ENSP00000256178
resolver
enst
ENST00000256178
resolver
genesymbol
LYVE1
resolver
genesymbol
XLKD1
resolver
genesymbol_syn
CRSBP1
resolver
genesymbol_syn
HAR
resolver
genesymbol_syn
XLKD1
resolver
hgnc
HGNC:14687
resolver
uniprot
B2R672
resolver
uniprot
Q8TC18
resolver
uniprot
Q9UNF4
resolver
uniprot_entry
B2R672_HUMAN
resolver
uniprot_entry
LYVE1_HUMAN
resolver
uniprot_sec
Q8TC18
resolver
uniprot_sec
Q9UNF4
resolver
amino_acid_sequence
MARCFSLVLLLTSIWTTRLLVQGSLRAEELSIQVSCRIMGITLVSKKANQQLNFTEAKEACRLLGLSLAGKDQVETALKASFETCSYGWVGDGFVVISRISPNPKCGKNGVGVLIWKVPVSRQFAAYCYNSSDTWTNSCIPEIITTKDPIFNTQTATQTTEFIVSDSTYSVASPYSTIPAPTTTPPAPASTSIPRRKKLICVTEVFMETSTMSTETEPFVENKAAFKNEAAGFGGVPTALLVLALLFFGAAAGLGFCYVKRYVKAFPFTNKNQQKEMIETKVVKEEKANDSNPNEESKKTDKNPEESKSPSKTTVRCLEAEV
uniprot
proteins
function
FUNCTION: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:10037799). Binds to pericellular hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (PubMed:26823460). {ECO:0000269|PubMed:10037799, ECO:0000269|PubMed:26823460}.
uniprot
proteins
mass_dalton
35213
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
10037799
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
26823460
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10037799, ECO:0000269|PubMed:26823460}; Single-pass type I membrane protein {ECO:0000269|PubMed:10037799}. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. Localizes at cell-cell junctions.
uniprot
proteins
transmembrane_region
TRANSMEM 239..259; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins