Six4
entrez
20474
canonical
uniprot
Q61321
canonical
ensembl
ENSMUSG00000034460
resolver
ensp
ENSMUSP00000036150
resolver
ensp
ENSMUSP00000135699
resolver
enst
ENSMUST00000175693
resolver
genesymbol
Six4
resolver
genesymbol_syn
Arec3
resolver
uniprot
B2RQH3
resolver
uniprot
H3BL91
resolver
uniprot
Q61322
resolver
uniprot
Q61323
resolver
uniprot_entry
H3BL91_MOUSE
resolver
uniprot_entry
SIX4_MOUSE
resolver
uniprot_sec
B2RQH3
resolver
uniprot_sec
Q61322
resolver
uniprot_sec
Q61323
resolver
amino_acid_sequence
MSSSSPTGQIASAADIKQENGMESASEGQEAHREVAGGAAAGLSPPAPAPFPLEPGDAAAASRVSREEGAAAAGAADQVQLHSELLGRHQHAAAAQPPLAFSPDHVACVCEALQQGGNLDRLARFLWSLPQSDLLRGNESLLKARALVAFHQGIYPELYSILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVDKYRLRRKFPLPRTIWDGEETVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQVSNWFKNRRQRDRNPSETQSKSESDGNPSTEDESSKGHEDLSPHPLSGASDGVTNLSLSSHVEPVYMQQIGNAKISLSSSGVLLNGSLVPASTSPVFLNGNSFIQGHNGVILNGLNVGNTQTVSLNPPKMSSNIVGNGIAMTDILGSTSQDVKEFKVLQSSAVNSAATTSYSPSAPVSFPGLIPCTEVKREGIQTVASQDGGSVVTFTTPVQINQYGIVQIPNSGANGQFLNGSIGFSPLQLPPVSVAASQGNLSVTPSTSDGSTFTSEPATVQHGKLFLSPLTPSAVVYTVPNSGQTVGAVKQEGLERGLVFSQLMPVNHSAQVNASLSSENLSGSGLHPLTSSLVNVSAAHGFSLTPPTLLNPTELNPDLAESQPVSAPVASKCTVSSVSNTNYATLQNCSLIPGQDLLSGPMTQAALGEIVPTAEEQVSHASTAVHQDFVREQRLVLQSVPNIKENFLQNSENKATNNLMMLDSKSKYVLDGMVEAGCEDLGTDKKELAKLQTVQLDEDMQDL
uniprot
proteins
function
FUNCTION: Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and from a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer (PubMed:14966291). Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein (PubMed:10490620). Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1 (PubMed:15788460). Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6 (PubMed:15788460, PubMed:17592144). Controls somitic differentiation in myocyte through MYOG transactivation (PubMed:15788460). Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3 (PubMed:19962975, PubMed:21884692). Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes (PubMed:21884692). During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression (PubMed:20696153). During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression (PubMed:17300925). Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation (PubMed:23987514). During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation (PubMed:19027001). Promotes survival of sensory neurons during early trigeminal gangliogenesis (PubMed:16938278). In the developing dorsal root ganglia, up-regulates SLC12A2 transcription (PubMed:15955062). Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression (PubMed:16530750). Forms gustatory papillae during development of the tongue (PubMed:21978088). Also plays a role during embryonic cranial skeleton morphogenesis (PubMed:20515681). {ECO:0000269|PubMed:10490620, ECO:0000269|PubMed:14966291, ECO:0000269|PubMed:15788460, ECO:0000269|PubMed:15955062, ECO:0000269|PubMed:16530750, ECO:0000269|PubMed:16938278, ECO:0000269|PubMed:17300925, ECO:0000269|PubMed:17592144, ECO:0000269|PubMed:19027001, ECO:0000269|PubMed:19962975, ECO:0000269|PubMed:20515681, ECO:0000269|PubMed:20696153, ECO:0000269|PubMed:21884692, ECO:0000269|PubMed:21978088, ECO:0000269|PubMed:23987514, ECO:0000303|PubMed:10490620}.
uniprot
proteins
mass_dalton
82263
uniprot
proteins
protein_family
SIX/Sine oculis homeobox family
uniprot
proteins
pubmed
10490620
uniprot
proteins
pubmed
11313460
uniprot
proteins
pubmed
12215533
uniprot
proteins
pubmed
14966291
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15788460
uniprot
proteins
pubmed
15955062
uniprot
proteins
pubmed
16530750
uniprot
proteins
pubmed
16938278
uniprot
proteins
pubmed
17300925
uniprot
proteins
pubmed
17592144
uniprot
proteins
pubmed
19027001
uniprot
proteins
pubmed
19962975
uniprot
proteins
pubmed
20515681
uniprot
proteins
pubmed
20696153
uniprot
proteins
pubmed
21884692
uniprot
proteins
pubmed
21978088
uniprot
proteins
pubmed
23987514
uniprot
proteins
pubmed
8628654
uniprot
proteins
pubmed
9990334
uniprot
proteins
sequence_length
775
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8628654, ECO:0000269|PubMed:9990334}. Cytoplasm {ECO:0000269|PubMed:8628654, ECO:0000269|PubMed:9990334}.
uniprot
proteins