Tnfaip3
entrez
21929
canonical
uniprot
Q60769
canonical
ensembl
ENSMUSG00000019850
resolver
ensp
ENSMUSP00000019997
resolver
ensp
ENSMUSP00000101167
resolver
enst
ENSMUST00000019997
resolver
enst
ENSMUST00000105527
resolver
genesymbol
Tnfaip3
resolver
genesymbol_syn
Tnfip3
resolver
uniprot
Q3TBB9
resolver
uniprot
Q3U968
resolver
uniprot
Q7TQD1
resolver
uniprot_entry
Q3TBB9_MOUSE
resolver
uniprot_entry
Q7TQD1_MOUSE
resolver
uniprot_entry
TNAP3_MOUSE
resolver
uniprot_sec
Q3U968
resolver
amino_acid_sequence
MAEQLLPQALYLSNMRKAVKIRERTPEDIFKPTNGIIYHFKTMHRYTLEMFRTCQFCPQFREIIHKALIDRSVQASLESQKKLNWCREVRKLVALKTNGDGNCLMHAACQYMWGVQDTDLVLRKALCSTLKETDTRNFKFRWQLESLKSQEFVETGLCYDTRNWNDEWDNLVKMASADTPAARSGLQYNSLEEIHIFVLSNILRRPIIVISDKMLRSLESGSNFAPLKVGGIYLPLHWPAQECYRYPIVLGYDSQHFVPLVTLKDSGPELRAVPLVNRDRGRFEDLKVHFLTDPENEMKEKLLKEYLIVMEIPVQGWDHGTTHLINAAKLDEANLPKEINLVDDYFELVQHEYKKWQENSDQARRAAHAQNPLEPSTPQLSLMDIKCETPNCPFFMSVNTQPLCHECSERRQKNQSKLPKLNSKLGPEGLPGVGLGSSNWSPEETAGGPHSAPPTAPSLFLFSETTAMKCRSPGCPFTLNVQHNGFCERCHARQINASHTADPGKCQACLQDVTRTFNGICSTCFKRTTAEPSSSLTSSIPASCHQRSKSDPSQLIQSLTPHSCHRTGNVSPSGCLSQAARTPGDRAGTSKCRKAGCMYFGTPENKGFCTLCFIEYRENKQSVTASEKAGSPAPRFQNNVPCLGRECGTLGSTMFEGYCQKCFIEAQNQRFHEARRTEEQLRSSQHRDMPRTTQVASRLKCARASCKNILACRSEELCMECQHLSQRVGSVAHRGEPTPEEPPKQRCRAPACDHFGNAKCNGYCNECYQFKQMYG
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
ec_number
3.4.19.12
uniprot
proteins
function
FUNCTION: Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of pro-inflammatory cytokines and IFN beta in LPS-tolerized macrophages. {ECO:0000269|PubMed:10385526, ECO:0000269|PubMed:11389905, ECO:0000269|PubMed:15334086, ECO:0000269|PubMed:18342009, ECO:0000269|PubMed:20185725, ECO:0000269|PubMed:23609450}.
uniprot
proteins
mass_dalton
87654
uniprot
proteins
mutagenesis
MUTAGEN 100; /note="D->A: Loss of deubiquitinating activity."; /evidence="ECO:0000269|PubMed:15334086"; MUTAGEN 103; /note="C->A: Loss of deubiquitinating activity, does not disassemble TRAF6:UBE2N ubiquitin ligase complex, abolioshes TAX1BP1 interaction with UBE2N."; /evidence="ECO:0000269|PubMed:15334086, ECO:0000269|PubMed:20185725
uniprot
proteins
protein_family
Peptidase C64 family
uniprot
proteins
pubmed
10385526
uniprot
proteins
pubmed
11389905
uniprot
proteins
pubmed
15334086
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18342009
uniprot
proteins
pubmed
19131965
uniprot
proteins
pubmed
20185725
uniprot
proteins
pubmed
23609450
uniprot
proteins
pubmed
7836754
uniprot
proteins
sequence_length
775
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Lysosome {ECO:0000250}.
uniprot
proteins