Gnptg
entrez
214505
canonical
uniprot
Q6S5C2
canonical
ensembl
ENSMUSG00000035521
resolver
ensp
ENSMUSP00000042073
resolver
ensp
ENSMUSP00000110807
resolver
ensp
ENSMUSP00000359065
resolver
enst
ENSMUST00000038973
resolver
enst
ENSMUST00000115154
resolver
genesymbol
Gnptg
resolver
genesymbol_syn
Mdcp1
resolver
uniprot
A0A0R4J0H5
resolver
uniprot
A0A140T8R4
resolver
uniprot
Q7TNE0
resolver
uniprot
Q8C5J3
resolver
uniprot_entry
A0A0R4J0H5_MOUSE
resolver
uniprot_entry
A0A140T8R4_MOUSE
resolver
uniprot_entry
GNPTG_MOUSE
resolver
uniprot_sec
Q7TNE0
resolver
uniprot_sec
Q8C5J3
resolver
amino_acid_sequence
MAGRLAGFLMLLGLASQGPAPAYAGKMKVVEEPNTFGLNNPFLPQASRLQPKREPSAVSGPLHLFRLAGKCFSLVESTYKYEFCPFHNVTQHEQTFRWNAYSGILGIWHEWEIINNTFKGMWMTDGDSCHSRSRQSKVELTCGKINRLAHVSEPSTCVYALTFETPLVCHPHSLLVYPTLSEALQQRWDQVEQDLADELITPQGYEKLLRVLFEDAGYLKVPGETHPTQLAGGSKGLGLETLDNCRKAHAELSQEVQRLTSLLQQHGIPHTQPTETTHSQHLGQQLPIGAIAAEHLRSDPGLRGNIL
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of the N-acetylglucosamine-1-phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors. {ECO:0000269|PubMed:15716021}.
uniprot
proteins
mass_dalton
34169
uniprot
proteins
mutagenesis
MUTAGEN 84; /note="C->S: Abolishes homodimerization; when associated with S-157 and S-245. Does not affect homodimerization; when associated with S-157."; /evidence="ECO:0000269|PubMed:21173149"; MUTAGEN 88; /note="N->Q: Abolishes localization to the Golgi apparatus; when associated with Q-115."; /evidence="ECO:0000269|PubMed:21173149"; MUTAGEN 115; /note="N->Q: Abolishes localization to the Golgi apparatus; when associated with Q-88."; /evidence="ECO:0000269|PubMed:21173149"; MUTAGEN 142; /note="C->S: Does not affect homodimerization."; /evidence="ECO:0000269|PubMed:21173149"; MUTAGEN 157; /note="C->S: Abolishes homodimerization; when associated with S-84 S-245."; /evidence="ECO:0000269|PubMed:21173149"; MUTAGEN 169; /note="C->S: Does not affect homodimerization."; /evidence="ECO:0000269|PubMed:21173149"; MUTAGEN 245; /note="C->S: Abolishes homodimerization. Abolishes homodimerization; when associated with S-84 and S-157."; /evidence="ECO:0000269|PubMed:21173149
uniprot
proteins
post_translational_modification
PTM: Cys-245 mediates the formation of the interchain disulfide bond for formation of the homodimer. Cys-142, Cys-157 and Cys-169 are involved in intramolecular disulfide bonds formation (PubMed:21173149). {ECO:0000269|PubMed:21173149}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15716021
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21173149
uniprot
proteins
sequence_length
307
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted. Golgi apparatus.
uniprot
proteins