Bex4
entrez
406217
canonical
uniprot
Q9CWT2
canonical
ensembl
ENSMUSG00000047844
resolver
ensp
ENSMUSP00000112226
resolver
ensp
ENSMUSP00000269191
resolver
ensp
ENSMUSP00000269192
resolver
enst
ENSMUST00000116527
resolver
genesymbol
Bex4
resolver
uniprot
Q14BB8
resolver
uniprot_entry
BEX4_MOUSE
resolver
uniprot_entry
Q14BB8_MOUSE
resolver
amino_acid_sequence
MASKFKQVILDLTVEKDKKDKKGGKASKQSEEEPHHLEEVENKKPGGNVRRKVRRLVPNFLWAIPNRHVDRNEGGEDVGRFVVQGTEVKRKTTEQQVRPYRRFRTPEPDNHYDFCLIP
uniprot
proteins
function
FUNCTION: May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (PubMed:34562363). {ECO:0000250|UniProtKB:Q9NWD9, ECO:0000269|PubMed:34562363}.
uniprot
proteins
mass_dalton
13820
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated and degraded by the proteasome. {ECO:0000250|UniProtKB:Q3MKP9}.
uniprot
proteins
protein_family
BEX family
uniprot
proteins
pubmed
15958283
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
28145533
uniprot
proteins
pubmed
28295929
uniprot
proteins
pubmed
34562363
uniprot
proteins
sequence_length
118
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9NWD9}. Nucleus {ECO:0000250|UniProtKB:Q9NWD9}. Cytoplasm {ECO:0000269|PubMed:28295929}. Note=Also localizes to microtubules. {ECO:0000250|UniProtKB:Q9NWD9}.
uniprot
proteins