Armcx3
entrez
71703
canonical
uniprot
Q8BHS6
canonical
ensembl
ENSMUSG00000049047
resolver
ensp
ENSMUSP00000080518
resolver
ensp
ENSMUSP00000084093
resolver
ensp
ENSMUSP00000084097
resolver
ensp
ENSMUSP00000322004
resolver
ensp
ENSMUSP00000322019
resolver
enst
ENSMUST00000081834
resolver
enst
ENSMUST00000086880
resolver
enst
ENSMUST00000086884
resolver
genesymbol
Armcx3
resolver
genesymbol_syn
Alex3
resolver
uniprot
A2AKS4
resolver
uniprot
Q91VP8
resolver
uniprot
Q9DC32
resolver
uniprot_entry
ARMX3_MOUSE
resolver
uniprot_sec
A2AKS4
resolver
uniprot_sec
Q91VP8
resolver
uniprot_sec
Q9DC32
resolver
amino_acid_sequence
MGYARKVGWVTAGLVIGAGACYCIYRLTRGRKQNKEKMAEGGSGDVDDAGDCSGARYNDWSDDDDDSNESKSIVWYPPWARIGTEAGTRARARARARATRARRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTVTSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDFFRLFSAGNEETKLQVLKLLLNLAENPAMTRELLRAQVPSSLGSLFNKKEYKEVILKLLIIFENINDNFKWEENEPAQNHFSEGSLFFFLKEFQVCADKVLGIESRHDFQVRVKVGKFVAKLTERMFPKSQE
uniprot
proteins
function
FUNCTION: Regulates mitochondrial aggregation and transport in axons in living neurons (PubMed:22569362, PubMed:23844091). May link mitochondria to the Trak2-kinesin motor complex via its interaction with Miro and Trak2 (PubMed:22569362). Mitochondrial distribution and dynamics is regulated through Armcx3 protein degradation, which is promoted by PCK and negatively regulated by Wnt1 (PubMed:23844091). Enhances the Sox10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters (PubMed:19304657). {ECO:0000269|PubMed:19304657, ECO:0000269|PubMed:22569362, ECO:0000269|PubMed:23844091}.
uniprot
proteins
mass_dalton
42620
uniprot
proteins
protein_family
Eutherian X-chromosome-specific Armcx family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19304657
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22569362
uniprot
proteins
pubmed
23844091
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:19304657, ECO:0000269|PubMed:22569362}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:22569362}. Nucleus {ECO:0000269|PubMed:22569362}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..29; /note="Helical; Signal-anchor"; /evidence="ECO:0000255
uniprot
proteins