Mavs
entrez
228607
canonical
uniprot
Q8VCF0
canonical
ensembl
ENSMUSG00000037523
resolver
ensp
ENSMUSP00000038339
resolver
ensp
ENSMUSP00000105828
resolver
enst
ENSMUST00000041362
resolver
enst
ENSMUST00000110199
resolver
genesymbol
Mavs
resolver
genesymbol_syn
Ips1
resolver
genesymbol_syn
Visa
resolver
uniprot
Q3U5B1
resolver
uniprot_entry
MAVS_MOUSE
resolver
uniprot_entry
Q3U5B1_MOUSE
resolver
amino_acid_sequence
MTFAEDKTYKYIRDNHSKFCCVDVLEILPYLSCLTASDQDRLRASYRQIGNRDTLWGLFNNLQRRPGWVEVFIRALQICELPGLADQVTRVYQSYLPPGTSLRSLEPLQLPDFPAAVSGPSAFAPGHNIPDHGLRETPSCPKPVQDTQPPESPVENSEQLLQTNSGAVARMSGGSLIPSPNQQALSPQPSREHQEQEPELGGAHAANVASVPIATYGPVSPTVSFQPLPRTALRTNLLSGVTVSALSADTSLSSSSTGSAFAKGAGDQAKAATCFSTTLTNSVTTSSVPSPRLVPVKTMSSKLPLSSKSTAAMTSTVLTNTAPSKLPSNSVYAGTVPSRVPASVAKAPANTIPPERNSKQAKETPEGPATKVTTGGNQTGPNSSIRSLHSGPEMSKPGVLVSQLDEPFSACSVDLAISPSSSLVSEPNHGPEENEYSSFRIQVDESPSADLLGSPEPLATQQPQEEEEHCASSMPWAKWLGATSALLAVFLAVMLYRSRRLAQ
uniprot
proteins
function
FUNCTION: Adapter required for innate immune defense against viruses (PubMed:24037184). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5) (PubMed:24037184). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (By similarity). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (By similarity). May activate the same pathways following detection of extracellular dsRNA by TLR3 (By similarity). May protect cells from apoptosis (By similarity). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000250|UniProtKB:Q7Z434, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:24037184}.
uniprot
proteins
mass_dalton
53399
uniprot
proteins
post_translational_modification
PTM: Following activation, phosphorylated by TBK1 at Ser-418 in the pLxIS motif. The phosphorylated pLxIS motif constitutes an IRF3-binding motif, leading to recruitment of the transcription factor IRF3 to induce type-I interferons and other cytokines. {ECO:0000250|UniProtKB:Q7Z434}.; PTM: Ubiquitinated. Undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS/IPS1 proteasomal degradation. Ubiquitinated by RNF125, leading to its degradation by the proteasome. Undergoes 'Lys-48'-linked ubiquitination catalyzed by SMURF1. Undergoes 'Lys-48'-linked ubiquitination catalyzed by MARCHF5 at Lys-7, leading to proteasomal degradation (By similarity). Ubiquitinated via 'Lys-63'-linked ubiquitination at Lys-10 by TRIM31, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria. Undergoes 'Lys-63'-linked ubiquitination leading to enhanced interaction between MAVS and TRAF2. Undergoes 'Lys-27'-linked ubiquitination by UBE2N and TRIM21 leading to enhanced interaction between MAVS and TBK1 (By similarity). Deubiquitinated by USP10 leading to attenuation of RIGI-mediated MAVS aggregation and production of type I interferon (By similarity). Undergoes 'Lys-48'-linked polyubiquitination catalyzed by RNF115 leading to its degradation (By similarity). Deubiquitinated by USP4, leading to maintain MAVS protein stability, resulting in increased production of type I interferons (IFN-I) and enhanced antiviral innate immune responses against viral infections (By similarity). {ECO:0000250|UniProtKB:Q7Z434}.; PTM: Proteolytically cleaved by apoptotic caspases during apoptosis, leading to its inactivation. Cleavage by CASP3 during virus-induced apoptosis inactivates it, preventing cytokine overproduction. {ECO:0000250|UniProtKB:Q7Z434}.; PTM: Palmitoylated by ZHDDC4. Palmitoylation promotes MAVS stabilization and activation by inhibiting 'Lys-48'- but facilitating 'Lys-63'-linked ubiquitination. {ECO:0000250|UniProtKB:Q7Z434}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16125763
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16153868
uniprot
proteins
pubmed
16177806
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18849341
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23087404
uniprot
proteins
pubmed
23582325
uniprot
proteins
pubmed
24037184
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
31685995
uniprot
proteins
sequence_length
503
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q7Z434}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q7Z434}. Mitochondrion {ECO:0000269|PubMed:23582325}. Peroxisome {ECO:0000250|UniProtKB:Q7Z434}.
uniprot
proteins
transmembrane_region
TRANSMEM 479..496; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins