PPP2R2A
entrez
5520
canonical
uniprot
P63151
canonical
ensembl
ENSG00000221914
resolver
ensp
ENSP00000325074
resolver
ensp
ENSP00000370113
resolver
ensp
ENSP00000499441
resolver
ensp
ENSP00000675578
resolver
ensp
ENSP00000715932
resolver
enst
ENST00000660435
resolver
genesymbol
PPP2R2A
resolver
hgnc
HGNC:9304
resolver
uniprot
A0A140VJT0
resolver
uniprot
A0A590UJJ1
resolver
uniprot
B2RBU8
resolver
uniprot
B4E1T7
resolver
uniprot
P50409
resolver
uniprot
Q00007
resolver
uniprot_entry
2ABA_HUMAN
resolver
uniprot_entry
A0A140VJT0_HUMAN
resolver
uniprot_entry
A0A590UJJ1_HUMAN
resolver
uniprot_sec
B2RBU8
resolver
uniprot_sec
B4E1T7
resolver
uniprot_sec
P50409
resolver
uniprot_sec
Q00007
resolver
amino_acid_sequence
MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKVN
uniprot
proteins
function
FUNCTION: Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:1849734, PubMed:33108758). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). {ECO:0000250|UniProtKB:Q6P1F6, ECO:0000269|PubMed:1849734, ECO:0000269|PubMed:33108758}.
uniprot
proteins
mass_dalton
51692
uniprot
proteins
protein_family
Phosphatase 2A regulatory subunit B family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17245430
uniprot
proteins
pubmed
1849734
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25816751
uniprot
proteins
pubmed
27588481
uniprot
proteins
pubmed
28609714
uniprot
proteins
pubmed
30611118
uniprot
proteins
pubmed
33108758
uniprot
proteins
pubmed
38123684
uniprot
proteins
sequence_length
447
uniprot
proteins