TRIP10
entrez
9322
canonical
uniprot
Q15642
canonical
ensembl
ENSG00000125733
resolver
ensp
ENSP00000320117
resolver
ensp
ENSP00000320493
resolver
ensp
ENSP00000469360
resolver
ensp
ENSP00000647774
resolver
ensp
ENSP00000647777
resolver
enst
ENST00000596758
resolver
genesymbol
TRIP10
resolver
genesymbol_syn
CIP4
resolver
genesymbol_syn
STOT
resolver
genesymbol_syn
STP
resolver
hgnc
HGNC:12304
resolver
uniprot
B2R8A6
resolver
uniprot
B7WP22
resolver
uniprot
D6W645
resolver
uniprot
O15184
resolver
uniprot
Q53G22
resolver
uniprot
Q5TZN1
resolver
uniprot
Q6FI24
resolver
uniprot
Q8NFL1
resolver
uniprot
Q8TCY1
resolver
uniprot
Q8TDX3
resolver
uniprot
Q96RJ1
resolver
uniprot
W4VSQ9
resolver
uniprot_entry
CIP4_HUMAN
resolver
uniprot_entry
W4VSQ9_HUMAN
resolver
uniprot_sec
B2R8A6
resolver
uniprot_sec
B7WP22
resolver
uniprot_sec
D6W645
resolver
uniprot_sec
O15184
resolver
uniprot_sec
Q53G22
resolver
uniprot_sec
Q5TZN1
resolver
uniprot_sec
Q6FI24
resolver
uniprot_sec
Q8NFL1
resolver
uniprot_sec
Q8TCY1
resolver
uniprot_sec
Q8TDX3
resolver
uniprot_sec
Q96RJ1
resolver
amino_acid_sequence
MDWGTELWDQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAKDDPESKFSQQQSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRSHMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELEVVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGFARPGDVEFEDFSQPMNRAPSDSSLGTPSDGRPELRGPGRSRTKRWPFGKKNKPRPPPLSPLGGPVPSALPNGPPSPRSGRDPLAILSEISKSVKPRLASFRSLRGSRGTVVTEDFSHLPPEQQRKRLQQQLEERSRELQKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTSPIGHCVAIYHFEGSSEGTISMAEGEDLSLMEEDKGDGWTRVRRKEGGEGYVPTSYLRVTLN
uniprot
proteins
function
FUNCTION: Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}.
uniprot
proteins
mass_dalton
68352
uniprot
proteins
mutagenesis
MUTAGEN 454; /note="I->S: Abrogates interaction with CDC42."; /evidence="ECO:0000269|PubMed:10713100"; MUTAGEN 468; /note="L->S: Impairs interaction with CDC42."; /evidence="ECO:0000269|PubMed:10713100
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated. Also phosphorylated by PKA. {ECO:0000269|PubMed:12456510, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:16343437}.
uniprot
proteins
protein_family
FNBP1 family
uniprot
proteins
pubmed
10713100
uniprot
proteins
pubmed
11069762
uniprot
proteins
pubmed
11294612
uniprot
proteins
pubmed
11431473
uniprot
proteins
pubmed
11691828
uniprot
proteins
pubmed
12054674
uniprot
proteins
pubmed
12456510
uniprot
proteins
pubmed
12604778
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15047863
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16318909
uniprot
proteins
pubmed
16326391
uniprot
proteins
pubmed
16343437
uniprot
proteins
pubmed
16630611
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17512409
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19387844
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7776974
uniprot
proteins
pubmed
9210375
uniprot
proteins
sequence_length
601
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Note=Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm, perinuclear region.
uniprot
proteins