Ggh
entrez
25455
canonical
uniprot
Q62867
canonical
ensembl
ENSRNOG00000007351
resolver
ensembl
ENSRNOG00055000363
resolver
ensembl
ENSRNOG00060001092
resolver
ensembl
ENSRNOG00065016092
resolver
ensp
ENSRNOP00000009758
resolver
ensp
ENSRNOP00055000509
resolver
ensp
ENSRNOP00060000738
resolver
ensp
ENSRNOP00065021002
resolver
enst
ENSRNOT00000009758
resolver
enst
ENSRNOT00055000647
resolver
enst
ENSRNOT00060001507
resolver
enst
ENSRNOT00065026755
resolver
genesymbol
Ggh
resolver
uniprot_entry
GGH_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activity is altered by insulin and estrogen.
uniprot
proteins
amino_acid_sequence
MASLGRLLCAWVLLLCGLASPGLSGSYERGSKRPIIGIIMQECYGNMTKLGRFYIAASYVKFIESAGARVVPIRLDLNDAQYETLFRSINGVLLPGGGANLTHSGYSRVAKIFFTKALESFDNGDYFPVWGTCLGLEELSVLVSNDNLLTLTNTSSVKLPLNFTRDSKQSRMFRNLPEELLNSLASENLTANFHKWSLSVKNFTENEKLKKFFNILTVNTDGKTEFISSMEGYKYPIYAVQWHPEKAPFEWKKLRGISHAPNAVKTSFYLAKFFISEALKNDHHFENELEETESLIYQFCPVYTGNISSFQQAYMFN
uniprot
proteins
ec_number
3.4.19.9
uniprot
proteins
function
FUNCTION: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates (PubMed:8343522, PubMed:8621474). Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Exhibits either endo- or exopeptidase activity depending upon the tissue of origin. When secreted, it acts primarily as an endopeptidase (By similarity). {ECO:0000250|UniProtKB:Q92820, ECO:0000269|PubMed:8343522, ECO:0000269|PubMed:8621474}.
uniprot
proteins
mass_dalton
35830
uniprot
proteins
protein_family
Peptidase C26 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
8343522
uniprot
proteins
pubmed
8621474
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250|UniProtKB:Q92820}. Lysosome {ECO:0000250|UniProtKB:Q92820}. Melanosome {ECO:0000250|UniProtKB:Q92820}. Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. {ECO:0000250|UniProtKB:Q92820}.
uniprot
proteins