GBP3
entrez
2635
canonical
uniprot
Q9H0R5
canonical
ensembl
ENSG00000117226
resolver
ensp
ENSP00000359512
resolver
ensp
ENSP00000520850
resolver
ensp
ENSP00000549109
resolver
enst
ENST00000850557
resolver
genesymbol
GBP3
resolver
hgnc
HGNC:4184
resolver
uniprot
A0ABB0MVI2
resolver
uniprot
A2A317
resolver
uniprot
A6NF86
resolver
uniprot
B2RTW0
resolver
uniprot
F8UW81
resolver
uniprot
Q05D54
resolver
uniprot
Q5T8L8
resolver
uniprot
Q5T8L9
resolver
uniprot
Q6P3V3
resolver
uniprot
Q9NV33
resolver
uniprot_entry
A0ABB0MVI2_HUMAN
resolver
uniprot_entry
GBP3_HUMAN
resolver
uniprot_sec
A2A317
resolver
uniprot_sec
A6NF86
resolver
uniprot_sec
B2RTW0
resolver
uniprot_sec
F8UW81
resolver
uniprot_sec
Q05D54
resolver
uniprot_sec
Q5T8L8
resolver
uniprot_sec
Q5T8L9
resolver
uniprot_sec
Q6P3V3
resolver
uniprot_sec
Q9NV33
resolver
amino_acid_sequence
MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:22106366). Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). Exhibits antiviral activity against influenza virus (PubMed:22106366). {ECO:0000250|UniProtKB:Q61107, ECO:0000269|PubMed:22106366}.; FUNCTION: [Isoform 2]: Shows the most prominent antiviral activity in epithelial cells. {ECO:0000269|PubMed:22106366}.
uniprot
proteins
mass_dalton
68114
uniprot
proteins
mutagenesis
MUTAGEN 105; /note="K->E: Promotes ubiquitination and degradation by S. flexneri IpaH9.8."; /evidence="ECO:0000269|PubMed:31216343
uniprot
proteins
protein_family
GB1 subfamily
uniprot
proteins
protein_family
GB1/RHD3 GTPase family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17266443
uniprot
proteins
pubmed
21151871
uniprot
proteins
pubmed
22106366
uniprot
proteins
pubmed
31216343
uniprot
proteins
sequence_length
595
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17266443}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21151871}. Golgi apparatus membrane {ECO:0000269|PubMed:21151871}. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP5, at the Golgi apparatus. {ECO:0000269|PubMed:21151871}.
uniprot
proteins