Scnn1b
entrez
24767
canonical
uniprot
P37090
canonical
ensembl
ENSRNOG00000030981
resolver
ensp
ENSRNOP00000063755
resolver
enst
ENSRNOT00000067138
resolver
genesymbol
Scnn1b
resolver
uniprot
A0A9K3Y6R5
resolver
uniprot
B8QP48
resolver
uniprot
F1LQG4
resolver
uniprot
O09183
resolver
uniprot_entry
A0A9K3Y6R5_RAT
resolver
uniprot_entry
B8QP48_RAT
resolver
uniprot_entry
SCNNB_RAT
resolver
uniprot_sec
F1LQG4
resolver
uniprot_sec
O09183
resolver
activity_regulation
ACTIVITY REGULATION: Originally identified and characterized by its inhibition by the diuretic drug amiloride. {ECO:0000269|PubMed:8107805}.
uniprot
proteins
amino_acid_sequence
MPVKKYLLKCLHRLQKGPGYTYKELLVWYCNNTNTHGPKRIICEGPKKKAMWFLLTLLFACLVCWQWGVFIQTYLSWEVSVSLSMGFKTMNFPAVTVCNSSPFQYSKVKHLLKDLYKLMEAVLDKILAPKSSHTNTTSTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMRLCSANGTVCTFRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILACLFGTEPCSHRNFTPIFYPDYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLLDKLQGKGEPYSPCTMNGSDVAIQNLYSDYNTTYSIQACLHSCFQDHMIHNCSCGHYLYPLPAGEKYCNNRDFPDWAYCYLSLQMSVVQRETCLSMCKESCNDTQYKMTISMADWPSEASEDWILHVLSQERDQSSNITLSRKGIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITVIKLVASCKGLRRRRPQAPYTGPPPTVAELVEAHTNFGFQPDTTSCRPNAEVYPDQQTLPIPGTPPPNYDSLRLQPLDTMESDSEVEAI
uniprot
proteins
function
FUNCTION: This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:8107805, PubMed:9118951). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:11352848, PubMed:11773057, PubMed:9118951). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (By similarity). This subunit is not essential for ENaC function in airway surface liquid homeostasis and proper mucus clearance (By similarity). {ECO:0000250|UniProtKB:Q9WU38, ECO:0000269|PubMed:11352848, ECO:0000269|PubMed:11773057, ECO:0000269|PubMed:8107805, ECO:0000269|PubMed:9118951}.
uniprot
proteins
mass_dalton
71995
uniprot
proteins
mutagenesis
MUTAGEN 615; /note="P->A: Decreased interaction with NEDD4."; /evidence="ECO:0000269|PubMed:8665844"; MUTAGEN 616; /note="P->A: Loss of interaction with NEDD4. Loss of inhibition by NEDD4 and NEDD4L."; /evidence="ECO:0000269|PubMed:12654927, ECO:0000269|PubMed:8665844"; MUTAGEN 618; /note="Y->A: Loss of interaction with NEDD4. Loss of inhibition by NEDD4 and NEDD4L."; /evidence="ECO:0000269|PubMed:12654927, ECO:0000269|PubMed:8665844"; MUTAGEN 621; /note="L->A: Decreased interaction with NEDD4. Decreased inhibition by NEDD4 and NEDD4L."; /evidence="ECO:0000269|PubMed:12654927
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Can be ubiquitinated at multiple sites and undergo monoubiquitination and polyubiquitination. Ubiquitination by NEDD4 or NEDD4L inhibits the ENaC channel through endocytosis, intracellular retention and degradation of its individual subunits (PubMed:11323714, PubMed:12654927, PubMed:8665844). However, some studies could not confirm the ubiquitination of this subunit of the ENaC (PubMed:9351815). {ECO:0000269|PubMed:11323714, ECO:0000269|PubMed:12654927, ECO:0000269|PubMed:8665844, ECO:0000269|PubMed:9351815}.; PTM: N-glycosylated (PubMed:11773057). N-glycosylation is required for interaction with BPIFA1 (By similarity). {ECO:0000250|UniProtKB:P51168, ECO:0000269|PubMed:11773057}.; PTM: Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. {ECO:0000269|PubMed:9501257}.
uniprot
proteins
protein_family
Amiloride-sensitive sodium channel (TC 1.A.6) family
uniprot
proteins
protein_family
SCNN1B subfamily
uniprot
proteins
pubmed
11323714
uniprot
proteins
pubmed
11352848
uniprot
proteins
pubmed
11773057
uniprot
proteins
pubmed
12654927
uniprot
proteins
pubmed
30659401
uniprot
proteins
pubmed
8107805
uniprot
proteins
pubmed
8665844
uniprot
proteins
pubmed
9039092
uniprot
proteins
pubmed
9118951
uniprot
proteins
pubmed
9351815
uniprot
proteins
pubmed
9501257
uniprot
proteins
sequence_length
638
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11352848, ECO:0000269|PubMed:11773057, ECO:0000269|PubMed:9118951}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P37089}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:11352848, ECO:0000269|PubMed:11773057}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P37089}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..71; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 531..551; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins