Ppp1r3c
entrez
53412
canonical
uniprot
Q7TMB3
canonical
ensembl
ENSMUSG00000067279
resolver
ensp
ENSMUSP00000084578
resolver
enst
ENSMUST00000087321
resolver
genesymbol
Ppp1r3c
resolver
genesymbol_syn
Ppp1r5
resolver
uniprot
O08541
resolver
uniprot
Q8BJW8
resolver
uniprot_entry
PPR3C_MOUSE
resolver
uniprot_sec
O08541
resolver
uniprot_sec
Q8BJW8
resolver
amino_acid_sequence
MSCTRMIHVLDPRPLTSSVMPVDMAMRICLAHSPPLKSFLGPYNGFQRRNFVNKLKPLKPCLSVKQEAKSQSEWKSPHNQAKKRVVFADSKGLSLTAIHVFSDLPEEPAWDLQFDLLDLNDISSSLKLHEEKNLVFDFPQPSTDYLSFRDRFQKNFVCLENCSLQDRTVTGTVKVKNVSFEKKVQVRITFDTWKTYTDVDCVYMKNVYSSSDSDTFSFAIDLPRVIPTEEKIEFCISYHANGRIFWDNNEGQNYRIVHVQWKPDGVQTQVAPKDCAFQQGPPKTEIEPTVFGSPRLASGLFPEWQSWGRVENLTSYR
uniprot
proteins
function
FUNCTION: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types. {ECO:0000269|PubMed:10683377, ECO:0000269|PubMed:10862764, ECO:0000269|PubMed:10998419, ECO:0000269|PubMed:12727934, ECO:0000269|PubMed:12805359, ECO:0000269|PubMed:15322104, ECO:0000269|PubMed:16354703, ECO:0000269|PubMed:9045612, ECO:0000269|PubMed:9242697, ECO:0000269|PubMed:9756875}.
uniprot
proteins
mass_dalton
36460
uniprot
proteins
mutagenesis
MUTAGEN 85; /note="V->A: Abolishes binding to PP1 but has no effect on binding to glycogen synthase, glycogen phosphorylase or glycogen; when associated with A-87."; /evidence="ECO:0000269|PubMed:10938087"; MUTAGEN 87; /note="F->A: Abolishes binding to PP1 but has no effect on binding to glycogen synthase, glycogen phosphorylase or glycogen; when associated with A-85."; /evidence="ECO:0000269|PubMed:10938087"; MUTAGEN 247; /note="D->A: Abolishes binding to glycogen synthase and glycogen phosphorylase but has no effect on binding to PP1 or glycogen; when associated with A-250."; /evidence="ECO:0000269|PubMed:10938087"; MUTAGEN 250; /note="E->A: Abolishes binding to glycogen synthase and glycogen phosphorylase but has no effect on binding to PP1 or glycogen; when associated with A-247."; /evidence="ECO:0000269|PubMed:10938087
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner. {ECO:0000250}.
uniprot
proteins
pubmed
10683377
uniprot
proteins
pubmed
10862764
uniprot
proteins
pubmed
10938087
uniprot
proteins
pubmed
10998419
uniprot
proteins
pubmed
12727934
uniprot
proteins
pubmed
12805359
uniprot
proteins
pubmed
15322104
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16354703
uniprot
proteins
pubmed
9045612
uniprot
proteins
pubmed
9242697
uniprot
proteins
pubmed
9756875
uniprot
proteins
sequence_length
317
uniprot
proteins