Spart
entrez
229285
canonical
uniprot
Q8R1X6
canonical
ensembl
ENSMUSG00000036580
resolver
ensp
ENSMUSP00000042367
resolver
ensp
ENSMUSP00000103605
resolver
ensp
ENSMUSP00000113621
resolver
ensp
ENSMUSP00000181108
resolver
ensp
ENSMUSP00000181110
resolver
ensp
ENSMUSP00000181111
resolver
ensp
ENSMUSP00000181124
resolver
ensp
ENSMUSP00000181125
resolver
genesymbol
Spart
resolver
genesymbol_syn
Kiaa0610
resolver
genesymbol_syn
Spg20
resolver
uniprot
Q3TVW1
resolver
uniprot
Q6ZQ87
resolver
uniprot
Q8BJD3
resolver
uniprot
Q8BM37
resolver
uniprot
Q8BZ63
resolver
uniprot_entry
Q3TVW1_MOUSE
resolver
uniprot_entry
SPART_MOUSE
resolver
uniprot_sec
Q6ZQ87
resolver
uniprot_sec
Q8BJD3
resolver
uniprot_sec
Q8BM37
resolver
uniprot_sec
Q8BZ63
resolver
amino_acid_sequence
MEREPENGEPAEIKIIKEAYEKAFMFVNKGLNTDELGQKEEAKNYYKQGIGHLLRGISIAAAEPGHTGPAWEAARQMQQKMKETLQNVRTRLEILEKGLATSLRNDLQDVPKLYPEFPPKDACKKSPEQESVSTAPQRAEVDGSASAACAGPSGAPSALPVPSPSCPAEAPPAYSPQAAEGHYTVSYGTDSGEFSSVGEDFYRNRSQPPPLETLGLDADELILIPNGVQIFFVNPAGEVSAPSYPGYLRIVRFLDNSLDTVLNRPPGFLQVCDWLYPLVPDRSPVLKCTVGAYMFPDTMLQAAGCFVGVVLSSELPEDDRELFEDLLRQMSDLRLQANWNREEDEFQIPGRSSHPSEPPKEASGTDVRQSSSSGSSIDQGSKDARHKGKRGKKTKDSSEEVNLSQIVPCEPSSEEKSKELPEWSEKVAHNILSGASWVSWGLVKGAEFTGKAIQKGASKLRERIQPEEKPVEVSPAVTRGLYIAKQATGGAAKVSQLLVDGVCTVANCVGKELAPHVKKHGSKLVPESLKRDKDGKSALDGAMVVAASSVQGFSTVWQGLECAAKCIVNNVSAETVQTVRYKYGHNAGEATHNAVDSAINVGLTAYNIDNIGIKAMVKKTAKQTGHTLLEDYQIVERPQRESQGGATSTEGRRDIGKQVEEEKPGAGKKDK
uniprot
proteins
function
FUNCTION: Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons (PubMed:37443287). Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy. Lipid transfer protein required for lipid droplet degradation, including by lipophagy. Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown. May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (By similarity). {ECO:0000250|UniProtKB:Q8N0X7, ECO:0000269|PubMed:37443287}.
uniprot
proteins
mass_dalton
72655
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; ubiquitination does not require ITCH and WWP1. {ECO:0000250|UniProtKB:Q8N0X7}.
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
37443287
uniprot
proteins
sequence_length
671
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8N0X7}. Midbody {ECO:0000250|UniProtKB:Q8N0X7}. Lipid droplet {ECO:0000250|UniProtKB:Q8N0X7}. Note=Transiently associated with endosomes. Colocalized with IST1 to the ends of Flemming bodies during cytokinesis. {ECO:0000250|UniProtKB:Q8N0X7}.
uniprot
proteins