PYHIN1
entrez
149628
canonical
uniprot
Q6K0P9
canonical
ensembl
ENSG00000163564
resolver
ensp
ENSP00000357117
resolver
ensp
ENSP00000357120
resolver
ensp
ENSP00000357122
resolver
ensp
ENSP00000376082
resolver
ensp
ENSP00000376083
resolver
genesymbol
PYHIN1
resolver
genesymbol_syn
IFIX
resolver
hgnc
HGNC:28894
resolver
uniprot
Q5T3W6
resolver
uniprot
Q6K0P6
resolver
uniprot
Q6K0P7
resolver
uniprot
Q6K0P8
resolver
uniprot
Q8WW65
resolver
uniprot_entry
IFIX_HUMAN
resolver
uniprot_sec
Q5T3W6
resolver
uniprot_sec
Q6K0P6
resolver
uniprot_sec
Q6K0P7
resolver
uniprot_sec
Q6K0P8
resolver
uniprot_sec
Q8WW65
resolver
amino_acid_sequence
MANNYKKIVLLKGLEVINDYHFRIVKSLLSNDLKLNPKMKEEYDKIQIADLMEEKFPGDAGLGKLIEFFKEIPTLGDLAETLKREKLKVANKIESIPVKGIIPSKKTKQKEVYPATPACTPSNRLTAKGAEETLGPQKRKKPSEEETGTKRSKMSKEQTRPSCSAGASTSTAMGRSPPPQTSSSAPPNTSSTESLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHLKTPQMPPTTPSSSSFTKKDETHPGAQSSPANFRITSPTVAPPLSSDTSTNRHPAVP
uniprot
proteins
function
FUNCTION: Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. {ECO:0000269|PubMed:16479015, ECO:0000269|PubMed:18247378}.
uniprot
proteins
mass_dalton
55065
uniprot
proteins
protein_family
HIN-200 family
uniprot
proteins
pubmed
15122330
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16479015
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18247378
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleoplasm.; SUBCELLULAR LOCATION: [Isoform 5]: Nucleus. Nucleus speckle.
uniprot
proteins