Ppp1r21
entrez
73825
canonical
uniprot
Q3TDD9
canonical
ensembl
ENSMUSG00000034709
resolver
ensp
ENSMUSP00000048443
resolver
genesymbol
Ppp1r21
resolver
genesymbol_syn
Ccdc128
resolver
genesymbol_syn
Klraq1
resolver
uniprot
B2RPZ6
resolver
uniprot
Q3KQN7
resolver
uniprot
Q3U2U9
resolver
uniprot
Q8BHS9
resolver
uniprot
Q9D1A1
resolver
uniprot_entry
PPR21_MOUSE
resolver
uniprot_sec
B2RPZ6
resolver
uniprot_sec
Q3KQN7
resolver
uniprot_sec
Q3U2U9
resolver
uniprot_sec
Q8BHS9
resolver
uniprot_sec
Q9D1A1
resolver
amino_acid_sequence
MASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQASSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEHHRHVEAELRSRLATLETEAAQHQAVIDGLTRKYMETIEKLQSDKAKLEVKSQTLEKEAKECRLRTEECQLQLKNLHEDLSGRLEESLSIINEKVPFNDTKCHLYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVPALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKMFSDHLTSYVRFLRKILPYQLKSLEEECESSLCTPALRARNLELSQDMKTMTAVFEKLQTYVTLLALPSTEPDGLLRTNYTSVLTNVGAALHGFHDVMKDISKHYSQKASIEHEIPTATQKLVTTNDCILSSAVTLTNGAGKIASFFGNNVDYFIASLSYGPKTASGFISPLSAECMLQYKKKAAAYMKSLRTPLAESVPYGEAVANRRVLLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADRLRGTTSAQLPGLAQENATVPIASSQEEAAAKVLTEPVQSTSLVGMLTRTPDSEAPDVESREDLIKSHYMARIAELTSQLQLADSKSVHFYAECRALSKRLALAEKSKETLTEEMRLASQNISRLQDELMTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMASKGNSKKTRNR
uniprot
proteins
function
FUNCTION: Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction. In the complex, PPP1R21 serves as a binding hub connecting all five complex subunits and mediating the binding to mRNA and early endosomes via RAB5A (By similarity). Putative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway (By similarity). {ECO:0000250|UniProtKB:Q6ZMI0}.
uniprot
proteins
mass_dalton
88338
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30520571
uniprot
proteins
sequence_length
780
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000250|UniProtKB:Q6ZMI0}.
uniprot
proteins