Clasp2
entrez
114514
canonical
uniprot
Q99JD4
canonical
ensembl
ENSRNOG00000009161
resolver
ensp
ENSRNOP00000012545
resolver
ensp
ENSRNOP00000071109
resolver
ensp
ENSRNOP00000078073
resolver
ensp
ENSRNOP00000083968
resolver
ensp
ENSRNOP00000095387
resolver
ensp
ENSRNOP00000095411
resolver
ensp
ENSRNOP00000095678
resolver
enst
ENSRNOT00000113161
resolver
enst
ENSRNOT00000117265
resolver
genesymbol
Clasp2
resolver
uniprot
A0A8I5ZKF9
resolver
uniprot
A0A8I6AMJ1
resolver
uniprot_entry
A0A8I5ZKF9_RAT
resolver
uniprot_entry
A0A8I6AMJ1_RAT
resolver
uniprot_entry
CLAP2_RAT
resolver
amino_acid_sequence
MRRLICKRICDYKSFDDEESVDGNRPSSAASAFKVPAPKTPGNPVNSARKPGSAGGPKAGGTSKEGGAGAVDEDDFIKAFTDVPSIQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSSKWSTANPSAVAGRVSVGGSKASPLPGSLQRSRSDIDVNAAAGAKAHHAAGQAVRSGRLGAGALNPGSYASLEDTSDKMDGTASEDGRVRAKLSTPLVAVGNAKTDSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGAQRILVNSASAQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGMSQSSRLSSSVSAMRVLNTGSDVEEAVADALLLGDIRTKKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMSEPLKRDPKKEDGDTVCSGPGMSDPRAGGDAPDSSQPALDNKASLLHSVPLHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERIEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLKEILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTGSKMKLLNLYIKRAQTGSAGADPTTDVSGQS
uniprot
proteins
function
FUNCTION: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000250|UniProtKB:O75122}.
uniprot
proteins
mass_dalton
140638
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3B. Phosphorylation by GSK3B may negatively regulate binding to microtubule lattices in lamella.
uniprot
proteins
protein_family
CLASP family
uniprot
proteins
pubmed
11290329
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1286
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O75122}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O75122}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:O75122}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:O75122}. Golgi apparatus {ECO:0000250|UniProtKB:Q8BRT1}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O75122}. Cell membrane {ECO:0000250|UniProtKB:O75122}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O75122}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:O75122}. Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2. Colocalizes with KANK1 at the cell cortex, likely recruited in cortical microtubule stabilization complexes (CMSC) at focal adhesions rims. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (By similarity). {ECO:0000250|UniProtKB:O75122}.
uniprot
proteins