Fosb
entrez
14282
canonical
uniprot
P13346
canonical
ensembl
ENSMUSG00000003545
resolver
ensp
ENSMUSP00000003640
resolver
ensp
ENSMUSP00000146789
resolver
genesymbol
Fosb
resolver
uniprot
A0A140LIE4
resolver
uniprot
A2RSD4
resolver
uniprot_entry
A2RSD4_MOUSE
resolver
uniprot_entry
FOSB_MOUSE
resolver
uniprot_sec
A0A140LIE4
resolver
amino_acid_sequence
MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPAVDPYDMPGTSYSTPGLSAYSTGGASGSGGPSTSTTTSGPVSARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSTSAKEDGFGWLLPPPPPPPLPFQSSRDAPPNLTASLFTHSEVQVLGDPFPVVSPSYTSSFVLTCPEVSAFAGAQRTSGSEQPSDPLNSPSLLAL
uniprot
proteins
function
FUNCTION: Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity (PubMed:1900040, PubMed:2498083). As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (PubMed:29272704). Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Exhibits transactivation activity in vitro (PubMed:17241283). Involved in the display of nurturing behavior towards newborns (PubMed:8706134). May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (PubMed:23303048, PubMed:30902680). Implicated in behavioral responses related to morphine reward and spatial memory (PubMed:18407360, PubMed:9294222). {ECO:0000250|UniProtKB:P53539, ECO:0000269|PubMed:17241283, ECO:0000269|PubMed:18407360, ECO:0000269|PubMed:1900040, ECO:0000269|PubMed:23303048, ECO:0000269|PubMed:2498083, ECO:0000269|PubMed:29272704, ECO:0000269|PubMed:30902680, ECO:0000269|PubMed:8706134, ECO:0000269|PubMed:9294222}.; FUNCTION: [Isoform 2]: Exhibits lower transactivation activity than isoform 1 in vitro (PubMed:17241283). The heterodimer with JUN does not display any transcriptional activity, and may thereby act as an transcriptional inhibitor (PubMed:1900040). May be involved in the regulation of neurogenesis in the hippocampus (PubMed:23303048). May play a role in synaptic modifications in nucleus accumbens medium spiny neurons and thereby play a role in adaptive and pathological reward-dependent learning, including maladaptive responses involved in drug addiction (PubMed:23319622). Seems to be more stably expressed with a half-life of ~9.5 hours in cell culture as compared to 1.5 hours half-life of isoform 1 (PubMed:18407360). {ECO:0000269|PubMed:17241283, ECO:0000269|PubMed:18407360, ECO:0000269|PubMed:1900040, ECO:0000269|PubMed:23303048, ECO:0000269|PubMed:23319622}.
uniprot
proteins
mass_dalton
35977
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="S->A: Increased degradation by the proteasome and a decrease in isoform 2/deltaFosB transactivation activity."; /evidence="ECO:0000269|PubMed:16687504"; MUTAGEN 27; /note="S->D: Increased protein stability."; /evidence="ECO:0000269|PubMed:16687504
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:16687504}.; PTM: [Isoform 2]: Phosphorylated at Ser-27 by CSNK2A1; phosphorylation increases protein stability and transactivation potential. {ECO:0000269|PubMed:16687504, ECO:0000269|PubMed:17241283}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
Fos subfamily
uniprot
proteins
pubmed
16687504
uniprot
proteins
pubmed
17241283
uniprot
proteins
pubmed
1741260
uniprot
proteins
pubmed
18407360
uniprot
proteins
pubmed
1900040
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20473292
uniprot
proteins
pubmed
23303048
uniprot
proteins
pubmed
23319622
uniprot
proteins
pubmed
2498083
uniprot
proteins
pubmed
26446228
uniprot
proteins
pubmed
29272704
uniprot
proteins
pubmed
30902680
uniprot
proteins
pubmed
8706134
uniprot
proteins
pubmed
9294222
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17241283, ECO:0000269|PubMed:23303048, ECO:0000269|PubMed:2498083, ECO:0000269|PubMed:30902680, ECO:0000269|PubMed:9294222}.
uniprot
proteins