Trim27
entrez
19720
canonical
uniprot
Q62158
canonical
ensembl
ENSMUSG00000021326
resolver
ensp
ENSMUSP00000021761
resolver
ensp
ENSMUSP00000152179
resolver
ensp
ENSMUSP00000152230
resolver
ensp
ENSMUSP00000152730
resolver
enst
ENSMUST00000021761
resolver
enst
ENSMUST00000221464
resolver
enst
ENSMUST00000222544
resolver
enst
ENSMUST00000223065
resolver
genesymbol
Trim27
resolver
genesymbol_syn
Rfp
resolver
uniprot
A0A1Y7VJ13
resolver
uniprot
A0A1Y7VKW0
resolver
uniprot
Q62157
resolver
uniprot
Q8C2Q5
resolver
uniprot
Q99LK1
resolver
uniprot_entry
A0A1Y7VJ13_MOUSE
resolver
uniprot_entry
A0A1Y7VKW0_MOUSE
resolver
uniprot_entry
TRI27_MOUSE
resolver
uniprot_sec
Q62157
resolver
uniprot_sec
Q8C2Q5
resolver
uniprot_sec
Q99LK1
resolver
amino_acid_sequence
MASGSVAECLQQETTCPVCLQYFVEPMMLDCGHNICCACLARCWGAAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEQDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNRLDHLRRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQFSCNISHLSGLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWAVSLWYGKEYWALTSPMTALPLRTPLQRVGIFLDYDAGEVSFYNVTERCHTFTFSHATFCGPVRPYFSLSYSGGKSAAPLIICPMSGIDGFSGHVGNHGHSMETSP
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy (PubMed:24144979). Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation (By similarity). Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (By similarity). Has a transcriptional repressor activity by cooperating with EPC1 (By similarity). Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events (By similarity). May function in male germ cell development (By similarity). Has DNA-binding activity and preferentially bound to double-stranded DNA (By similarity). Forms a complex with and ubiquitinates the ubiquitin-specific protease USP7, which in turn deubiquitinates RIPK1 resulting in the positive regulation of TNF-induced apoptosis (PubMed:24144979). In addition, acts with USP7 or PTPN11 as an inhibitor of the antiviral signaling pathway by promoting kinase TBK1 ubiquitination and degradation (By similarity). Acts as a negative regulator of NOD2 signaling by mediating ubiquitination of NOD2, promoting its degradation by the proteasome (By similarity). Alternatively, facilitates mitophagy via TBK1 activation (By similarity). Negatively regulates autophagy flux under basal conditions by directly polyubiquitinating ULK1 (By similarity). During starvation-induced autophagy, catalyzes non-degradative ubiquitination of the kinase STK38L promoting its activation and phosphorylation of ULK1 leading to its ubiquitination and degradation to restrain the amplitude and duration of autophagy (By similarity). {ECO:0000250|UniProtKB:P14373, ECO:0000269|PubMed:24144979}.
uniprot
proteins
mass_dalton
58513
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:24144979}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
10571821
uniprot
proteins
pubmed
1437549
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24144979
uniprot
proteins
pubmed
26365382
uniprot
proteins
pubmed
9023983
uniprot
proteins
sequence_length
513
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P14373}. Cytoplasm {ECO:0000250|UniProtKB:P14373}. Nucleus, PML body {ECO:0000250|UniProtKB:P14373}. Early endosome {ECO:0000250|UniProtKB:P14373}. Mitochondrion {ECO:0000250|UniProtKB:P14373}. Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2. Co-localizes with p62/SQSTM1 and TBK1 in cytoplasmic structures that are closely associated with the mitochondria (By similarity). {ECO:0000250|UniProtKB:P14373, ECO:0000269|PubMed:10571821}.
uniprot
proteins