Hmbs
entrez
15288
canonical
uniprot
P22907
canonical
ensembl
ENSMUSG00000032126
resolver
ensp
ENSMUSP00000076575
resolver
ensp
ENSMUSP00000095166
resolver
genesymbol
Hmbs
resolver
genesymbol_syn
Uros1
resolver
uniprot
Q3TIV0
resolver
uniprot
Q3UBC6
resolver
uniprot
Q3UPG1
resolver
uniprot_entry
HEM3_MOUSE
resolver
uniprot_entry
Q3UBC6_MOUSE
resolver
uniprot_entry
Q3UPG1_MOUSE
resolver
uniprot_sec
Q3TIV0
resolver
amino_acid_sequence
MSGNGGAATTAEENGSKMRVIRVGTRKSQLARIQTDTVVAMLKALYPGIQFEIIAMSTTGDKILDTALSKIGEKSLFTKELENALEKNEVDLVVHSLKDVPTILPPGFTIGAICKRENPCDAVVFHPKFIGKTLETLPEKSAVGTSSLRRVAQLQRKFPHLEFKSIRGNLNTRLRKLDELQEFSAIVLAVAGLQRMGWQNRVGQILHPEECMYAVGQGALAVEVRAKDQDILDLVSVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTVMKDGQLYLTGGVWSLDGSDSMQETMQATIQVPVQQEDGPEDDPQLVGITARNIPRGAQLAAENLGISLASLLLNKGAKNILDVARQLNDVR
uniprot
proteins
ec_number
2.5.1.61
uniprot
proteins
function
FUNCTION: As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact. {ECO:0000250|UniProtKB:P08397}.
uniprot
proteins
mass_dalton
39344
uniprot
proteins
pathway_participation
PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. {ECO:0000250|UniProtKB:P08397}.
uniprot
proteins
protein_family
HMBS family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
2768242
uniprot
proteins
pubmed
8563760
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:8563760}.
uniprot
proteins