Dnd1
entrez
213236
canonical
uniprot
Q6VY05
canonical
ensembl
ENSMUSG00000044595
resolver
ensp
ENSMUSP00000054412
resolver
genesymbol
Dnd1
resolver
genesymbol_syn
Rbms4
resolver
genesymbol_syn
Ter
resolver
uniprot
Q8CFK7
resolver
uniprot_entry
DND1_MOUSE
resolver
uniprot_sec
Q8CFK7
resolver
amino_acid_sequence
MQSKRECEQWCERVNPENKAALEAWVRETGIRLVQVNGQRKYGGPPPGWVGSPPPSGSEVYIGRLPQDVYEHQLIPLFQRVGRLYEFRLMMTFSGLNRGFAYARYSSRRGAQAAIATLHNHQLRPSCQLLVCRSTEKCELTVDGLPLSLNRRALLLALQPFGPCLQETLLLPSPGSAPSQIALLKFSTHRAAAMAKKALVEGQSRLCGEQVAVEWLKPDLKQHFRQQLAGPSLRFLRPDVSQLTQTREKLGSQGARAALQLLCQRMKLGSPVFLTKCLGTGPAGWHRFWYQVVIPGHPVPFSGLIWVVLASDWQDGHEVAKDAVSAQLLEALSEPRTSLWSPGAEAGTMVKQ
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Dnd1 are the cause of the Ter mutation phenotype. Ter mice are characterized by primordial germ cell loss and susceptibility to spontaneous testicular germ cell tumors (TGCT). They are sterile, but viable. Isoform 1 defects may be the cause of tumor development. {ECO:0000269|PubMed:15902260}.
uniprot
proteins
function
FUNCTION: RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression (By similarity). Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs (By similarity). Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs (By similarity). Does not bind to miRNAs (By similarity). Isoform 1 may play a role during primordial germ cell (PGC) survival. However, does not seem to be essential for PGC migration. {ECO:0000250}.
uniprot
proteins
mass_dalton
39076
uniprot
proteins
pubmed
12932328
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15902260
uniprot
proteins
pubmed
17291453
uniprot
proteins
pubmed
18509452
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Perinuclear germ granules, also called germ plasm or chromatoid body (By similarity). Colocalizes in perinuclear sites with APOBEC3. {ECO:0000250}.
uniprot
proteins