Ska1
entrez
66468
canonical
uniprot
Q9CPV1
canonical
ensembl
ENSMUSG00000036223
resolver
ensp
ENSMUSP00000049156
resolver
ensp
ENSMUSP00000137357
resolver
enst
ENSMUST00000040188
resolver
enst
ENSMUST00000177604
resolver
genesymbol
Ska1
resolver
uniprot
A0A0R4J0M5
resolver
uniprot
Q005W7
resolver
uniprot
Q8VE34
resolver
uniprot
Q9CYW9
resolver
uniprot_entry
SKA1_MOUSE
resolver
uniprot_sec
A0A0R4J0M5
resolver
uniprot_sec
Q005W7
resolver
uniprot_sec
Q8VE34
resolver
uniprot_sec
Q9CYW9
resolver
amino_acid_sequence
MDSELEDLCSYVNEKIGNIKKILSIRNLGQDPALKTTLSKIGDEIIAVNELLNKFELEIQYQEQTNSSLKELCESLREECEDVEHLKEHVPPHLPQVTATQSLVHKPEPDPKESDKAEEPGLPKKPPREQRIIKEMQFITMDEFSDVPAYMKSRLTYCQINDIIKEINKAVVSKYKIMHQPKASMSSVKRNLYQRFINEETKDTKGHHFIVEADIKEFTALKVDKRFYVIMHILRHCHRLSEVRGGGLTRYVIT
uniprot
proteins
function
FUNCTION: Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint (By similarity). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (By similarity). The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (By similarity). The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces (By similarity). The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules (By similarity). The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase (By similarity). In the complex, it mediates interactions with microtubules (By similarity). It also stimulates AURKB/Aurora B catalytic activity (By similarity). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (PubMed:22336914). {ECO:0000250|UniProtKB:Q96BD8, ECO:0000269|PubMed:22336914}.
uniprot
proteins
mass_dalton
29459
uniprot
proteins
protein_family
SKA1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22336914
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:22336914}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q96BD8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q96BD8}. Note=Localizes to bioriented kinetochores and spindle microtubules during metaphase in a NDC80 complex-dependent manner (By similarity). The SKA complex begins to concentrate at kinetochores before microtubule attachment but reaches maximum levels on bioriented metaphase chromosomes (By similarity). Localizes both to microtubule plus-ends and along the length of microtubules (By similarity). The localization of the SKA complex to kinetochores is positively regulated by kinase CDK1 (By similarity). The localization of the SKA complex to kinetochores is negatively regulated by protein serine/threonine kinase AURKB, and this action is opposed directly or indirectly by the PP1 and PP2A protein phosphatase complexes (By similarity). Localizes at the centrosome during interphase and prophase (By similarity). Localizes to the meiotic spindle, but not to kinetochores, from the stage of germinal vesicle breakdown (GVBD) to meiosis II (MII) (PubMed:22336914). {ECO:0000250|UniProtKB:Q96BD8, ECO:0000269|PubMed:22336914}.
uniprot
proteins