HTR6
entrez
3362
canonical
uniprot
P50406
canonical
ensembl
ENSG00000158748
resolver
ensp
ENSP00000289753
resolver
enst
ENST00000289753
resolver
genesymbol
HTR6
resolver
hgnc
HGNC:5301
resolver
uniprot
Q13640
resolver
uniprot
Q5TGZ1
resolver
uniprot_entry
5HT6R_HUMAN
resolver
uniprot_sec
Q13640
resolver
uniprot_sec
Q5TGZ1
resolver
amino_acid_sequence
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:36989299, PubMed:37327704, PubMed:8522988). Also has a high affinity for tricyclic psychotropic drugs (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35714614). HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:35714614, PubMed:37327704). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of mTOR signaling (PubMed:23027611). {ECO:0000250|UniProtKB:P31388, ECO:0000250|UniProtKB:Q9R1C8, ECO:0000269|PubMed:23027611, ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704, ECO:0000269|PubMed:8522988}.
uniprot
proteins
mass_dalton
46954
uniprot
proteins
mutagenesis
MUTAGEN 106; /note="D->A: Abolished G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:36989299"; MUTAGEN 110; /note="C->A: Decreased G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 111; /note="S->A,T: Decreased G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:37327704"; MUTAGEN 182; /note="L->A: Decreased G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 188; /note="F->A: Decreased G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:37327704"; MUTAGEN 192; /note="A->Y: Abolished G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 281; /note="W->A: Abolished G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:36989299"; MUTAGEN 284; /note="F->A: Abolished G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:37327704"; MUTAGEN 285; /note="F->A: Decreased G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 310; /note="Y->A: Decreased G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:37327704
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
23027611
uniprot
proteins
pubmed
35714614
uniprot
proteins
pubmed
36989299
uniprot
proteins
pubmed
37327704
uniprot
proteins
pubmed
7656980
uniprot
proteins
pubmed
8522988
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37327704}; Multi-pass membrane protein {ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..52; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704, ECO:0007744|PDB:7XTB, ECO:0007744|PDB:7YS6, ECO:0007744|PDB:8JLZ"; TRANSMEM 63..88; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704, ECO:0007744|PDB:7XTB, ECO:0007744|PDB:7YS6, ECO:0007744|PDB:8JLZ"; TRANSMEM 97..122; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704, ECO:0007744|PDB:7XTB, ECO:0007744|PDB:7YS6, ECO:0007744|PDB:8JLZ"; TRANSMEM 143..167; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704, ECO:0007744|PDB:7XTB, ECO:0007744|PDB:7YS6, ECO:0007744|PDB:8JLZ"; TRANSMEM 186..209; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:35714614, ECO:0007744|PDB:7XTB"; TRANSMEM 267..293; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704, ECO:0007744|PDB:7XTB, ECO:0007744|PDB:7YS6, ECO:0007744|PDB:8JLZ"; TRANSMEM 300..323; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704, ECO:0007744|PDB:7XTB, ECO:0007744|PDB:7YS6, ECO:0007744|PDB:8JLZ
uniprot
proteins