TSPAN1
entrez
10103
canonical
uniprot
O60635
canonical
ensembl
ENSG00000117472
resolver
ensp
ENSP00000361072
resolver
ensp
ENSP00000563479
resolver
ensp
ENSP00000563480
resolver
ensp
ENSP00000563481
resolver
ensp
ENSP00000563482
resolver
ensp
ENSP00000563483
resolver
ensp
ENSP00000563489
resolver
ensp
ENSP00000563490
resolver
ensp
ENSP00000642244
resolver
ensp
ENSP00000642245
resolver
ensp
ENSP00000642246
resolver
ensp
ENSP00000642247
resolver
ensp
ENSP00000642248
resolver
ensp
ENSP00000786716
resolver
enst
ENST00000372003
resolver
enst
ENST00000893420
resolver
enst
ENST00000893421
resolver
enst
ENST00000893422
resolver
enst
ENST00000893423
resolver
enst
ENST00000893424
resolver
enst
ENST00000893430
resolver
enst
ENST00000893431
resolver
enst
ENST00000972185
resolver
enst
ENST00000972186
resolver
enst
ENST00000972187
resolver
enst
ENST00000972188
resolver
enst
ENST00000972189
resolver
genesymbol
TSPAN1
resolver
hgnc
HGNC:20657
resolver
uniprot
D3DQ14
resolver
uniprot
O60745
resolver
uniprot
Q5VST0
resolver
uniprot_entry
TSN1_HUMAN
resolver
uniprot_sec
D3DQ14
resolver
uniprot_sec
O60745
resolver
uniprot_sec
Q5VST0
resolver
amino_acid_sequence
MQCFSFIKTMMILFNLLIFLCGAALLAVGIWVSIDGASFLKIFGPLSSSAMQFVNVGYFLIAAGVVVFALGFLGCYGAKTESKCALVTFFFILLLIFIAEVAAAVVALVYTTMAEHFLTLLVVPAIKKDYGSQEDFTQVWNTTMKGLKCCGFTNYTDFEDSPYFKENSAFPPFCCNDNVTNTANETCTKQKAHDQKVEGCFNQLLYDIRTNAVTVGGVAAGIGGLELAAMIVSMYLYCNLQ
uniprot
proteins
function
FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (PubMed:30066932, PubMed:30291375). Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways (By similarity). Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK (PubMed:30291375). Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process (PubMed:21836059). {ECO:0000250|UniProtKB:Q6AYR9, ECO:0000269|PubMed:21836059, ECO:0000269|PubMed:30066932, ECO:0000269|PubMed:30291375}.
uniprot
proteins
mass_dalton
26301
uniprot
proteins
mutagenesis
MUTAGEN 141; /note="N->A: Loss of glycosylation."; /evidence="ECO:0000269|PubMed:19508227"; MUTAGEN 154; /note="N->A: Loss of glycosylation."; /evidence="ECO:0000269|PubMed:19508227"; MUTAGEN 178; /note="N->A: Loss of glycosylation."; /evidence="ECO:0000269|PubMed:19508227"; MUTAGEN 184; /note="N->A: Loss of glycosylation."; /evidence="ECO:0000269|PubMed:19508227
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19508227
uniprot
proteins
pubmed
21836059
uniprot
proteins
pubmed
30066932
uniprot
proteins
pubmed
30291375
uniprot
proteins
pubmed
9714763
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21836059, ECO:0000269|PubMed:30291375}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:19508227}; Multi-pass membrane protein {ECO:0000269|PubMed:19508227}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 89..109; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 212..232; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins