DHFR2
entrez
200895
canonical
uniprot
Q86XF0
canonical
ensembl
ENSG00000178700
resolver
ensp
ENSP00000319170
resolver
ensp
ENSP00000377768
resolver
ensp
ENSP00000418415
resolver
ensp
ENSP00000480823
resolver
ensp
ENSP00000621403
resolver
enst
ENST00000314636
resolver
enst
ENST00000394221
resolver
enst
ENST00000461173
resolver
enst
ENST00000619045
resolver
enst
ENST00000951344
resolver
genesymbol
DHFR2
resolver
genesymbol_syn
DHFRL1
resolver
genesymbol_syn
DHFRP4
resolver
hgnc
HGNC:27309
resolver
uniprot
B3KV46
resolver
uniprot
D3DN30
resolver
uniprot
Q6P4I9
resolver
uniprot_entry
B3KV46_HUMAN
resolver
uniprot_entry
DYR2_HUMAN
resolver
uniprot_sec
D3DN30
resolver
uniprot_sec
Q6P4I9
resolver
amino_acid_sequence
MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSSVYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKFEVCEKDD
uniprot
proteins
ec_number
1.5.1.3
uniprot
proteins
function
FUNCTION: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR. {ECO:0000269|PubMed:21876184, ECO:0000269|PubMed:21876188}.
uniprot
proteins
mass_dalton
21620
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
uniprot
proteins
protein_family
Dihydrofolate reductase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21876184
uniprot
proteins
pubmed
21876188
uniprot
proteins
pubmed
25980602
uniprot
proteins
sequence_length
187
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21876184, ECO:0000269|PubMed:21876188}. Mitochondrion matrix {ECO:0000269|PubMed:21876188}. Mitochondrion inner membrane {ECO:0000269|PubMed:21876188}.
uniprot
proteins