Rbpms
entrez
19663
canonical
uniprot
Q9WVB0
canonical
ensembl
ENSMUSG00000031586
resolver
ensp
ENSMUSP00000033994
resolver
ensp
ENSMUSP00000033995
resolver
ensp
ENSMUSP00000055813
resolver
ensp
ENSMUSP00000140387
resolver
enst
ENSMUST00000033994
resolver
genesymbol
Rbpms
resolver
genesymbol_syn
Hermes
resolver
uniprot
Q78HG1
resolver
uniprot
Q8C586
resolver
uniprot
Q9CPU5
resolver
uniprot
T1ECW4
resolver
uniprot_entry
Q8C586_MOUSE
resolver
uniprot_entry
RBPMS_MOUSE
resolver
uniprot_entry
T1ECW4_MOUSE
resolver
uniprot_sec
Q78HG1
resolver
uniprot_sec
Q9CPU5
resolver
amino_acid_sequence
MNGGGKAEKENTPSEANLQEEEVRTLFVSGLPLDIKPRELYLLFRPFKGYEGSLIKLTSKQPVGFVSFDSRSEAEAAKNALNGIRFDPEIPQTLRLEFAKANTKMAKNKLVGTPNPSTPLPNTVPQFIAREPYELTVPALYPSSPEVWAPYPLYPAELAPALPPPAAFTYPASLHAQMRWIPPSEATSQGWKSRQFC
uniprot
proteins
function
FUNCTION: RNA binding protein that mediates the regulation of pre-mRNA alternative splicing (AS) (By similarity). Acts either as activator (FLNB, HSPG2, LIPA1, MYOCD, PTPRF and PPFIBP1) or repressor (TPM1, ACTN1, ITGA7, PIEZO1, LSM14B, MBNL1 and MBML2) of splicing events on specific pre-mRNA targets. Together with RNA binding proteins RBFOX2 and MBNL1/2, activates a splicing program associated with differentiated contractile vascular smooth muscle cells (SMC) by regulating AS of numerous pre-mRNA involved in actin cytoskeleton and focal adhesion machineries, suggesting a role in promoting a cell differentiated state (By similarity). Binds to introns, exons and 3'-UTR associated with tandem CAC trinucleotide motifs separated by a variable spacer region, at a minimum as a dimer. The minimal length of RNA required for RBPMS-binding tandem CAC motifs is 15 nt, with spacing ranging from 1 to 9 nt. Can also bind to CA dinucleotide repeats (By similarity). Mediates repression of TPM1 exon 3 by binding to CAC tandem repeats in the flanking intronic regions, followed by higher-order oligomerization and heterotypic interactions with other splicing regulators including MBNL1 and RBFOX2, which prevents assembly of ATP-dependent splicing complexes (By similarity). {ECO:0000250|UniProtKB:A0A8I6G705, ECO:0000250|UniProtKB:Q93062}.
uniprot
proteins
mass_dalton
21816
uniprot
proteins
pubmed
10096065
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
197
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q93062}. Cytoplasm {ECO:0000250|UniProtKB:Q93062}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q93062}. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q93062}.
uniprot
proteins