IHO1
entrez
339834
canonical
uniprot
Q8IYA8
canonical
ensembl
ENSG00000173421
resolver
ensp
ENSP00000296449
resolver
ensp
ENSP00000391788
resolver
ensp
ENSP00000407837
resolver
ensp
ENSP00000631170
resolver
genesymbol
IHO1
resolver
genesymbol_syn
CCDC36
resolver
hgnc
HGNC:27945
resolver
uniprot
B4DZP6
resolver
uniprot
C9JJL0
resolver
uniprot
Q05DG9
resolver
uniprot
Q96LP7
resolver
uniprot_entry
B4DZP6_HUMAN
resolver
uniprot_entry
IHO1_HUMAN
resolver
uniprot_sec
C9JJL0
resolver
uniprot_sec
Q05DG9
resolver
uniprot_sec
Q96LP7
resolver
amino_acid_sequence
MNFNVWNIKEMLSIPSGSGNKKSSNWNNNQNDYSSLSDSQFLFGSQFCPENSETLSAPLDFGAHLRHSKQSQQNYLEGEPSIFTKYQTKPQLFGGDIKDGGLFPPPLSVGKSKGLLEQFEEKKKRAKDKCDSETLYNFVSNVRESILRLQTSVEKSEDHLSSRSQSILDSLETVAKTLQETIQAQNDLVFEAVQDKGNMEQAILEMKKRFEARQGEFIEMKSNLKHLEVLVAQQSQEFQQLCEQLGQLNVPSVLAELKRLISVPPVKDSASQTSPPLAQSLNLTRQEKYTSEKPVLWQAQALPAAWNPGMGSLQPGEFDVWGEGAKNDDLQEEAALPAFGSHERNRHVKDKVVQTNCKNWAVTKTGAKNHGSSVPGHKIPSDRDLVSQGASQLTSLEINFSTSIKNACQKYQAQSMFLCDPREHLVIKQKDGTVEMRGKDKKQQPRKAHRAHRGRLIASKQKQIPIQTCKFNSKYQSPQPAISVPQSPFLGQQEPRAQPLHLQCPRSPRKPVCPILGGTVMPNKTVRAVQGRLLQLSRCSSQDNWLLSSSSQGDHQMSWFSDLNLGCSETPLCKEAGKNLLYDLGFDSSDDDGF
uniprot
proteins
function
FUNCTION: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. {ECO:0000250|UniProtKB:Q6PDM4}.
uniprot
proteins
mass_dalton
66343
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
27723721
uniprot
proteins
pubmed
31704776
uniprot
proteins
sequence_length
594
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q6PDM4}. Note=Specifically localizes to unsynapsed chromosomal regions during meiosis. {ECO:0000250|UniProtKB:Q6PDM4}.
uniprot
proteins