TNNT2
entrez
7139
canonical
uniprot
P45379
canonical
ensembl
ENSG00000118194
resolver
ensp
ENSP00000356287
resolver
ensp
ENSP00000356289
resolver
ensp
ENSP00000395163
resolver
ensp
ENSP00000408731
resolver
ensp
ENSP00000414036
resolver
ensp
ENSP00000422031
resolver
ensp
ENSP00000499593
resolver
ensp
ENSP00000519588
resolver
ensp
ENSP00000519589
resolver
ensp
ENSP00000519593
resolver
ensp
ENSP00000632056
resolver
ensp
ENSP00000632057
resolver
ensp
ENSP00000715236
resolver
ensp
ENSP00000772580
resolver
ensp
ENSP00000772584
resolver
enst
ENST00000714312
resolver
enst
ENST00000714317
resolver
genesymbol
TNNT2
resolver
hgnc
HGNC:11949
resolver
uniprot
A0AAQ5BHX3
resolver
uniprot
A2TDB9
resolver
uniprot
A8K3K6
resolver
uniprot
O60214
resolver
uniprot
Q15607
resolver
uniprot
Q99596
resolver
uniprot
Q99597
resolver
uniprot
Q9BUF6
resolver
uniprot
Q9UM96
resolver
uniprot_entry
A0AAQ5BHX3_HUMAN
resolver
uniprot_entry
Q15607_HUMAN
resolver
uniprot_entry
TNNT2_HUMAN
resolver
uniprot_sec
A2TDB9
resolver
uniprot_sec
A8K3K6
resolver
uniprot_sec
O60214
resolver
uniprot_sec
Q99596
resolver
uniprot_sec
Q99597
resolver
uniprot_sec
Q9BUF6
resolver
uniprot_sec
Q9UM96
resolver
amino_acid_sequence
MSDIEEVVEEYEEEEQEEAAVEEEEDWREDEDEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
uniprot
proteins
disease_involvement
DISEASE: Cardiomyopathy, familial hypertrophic, 2 (CMH2) [MIM:115195]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO:0000269|PubMed:10525521, ECO:0000269|PubMed:11034944, ECO:0000269|PubMed:12707239, ECO:0000269|PubMed:12974739, ECO:0000269|PubMed:15563892, ECO:0000269|PubMed:16199542, ECO:0000269|PubMed:21846512, ECO:0000269|PubMed:7898523, ECO:0000269|PubMed:8205619, ECO:0000269|PubMed:8989109, ECO:0000269|PubMed:9060892, ECO:0000269|PubMed:9140840, ECO:0000269|PubMed:9482583, ECO:0000269|Ref.19}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Cardiomyopathy, dilated, 1D (CMD1D) [MIM:601494]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269|PubMed:11106718, ECO:0000269|PubMed:11684629, ECO:0000269|PubMed:15542288, ECO:0000269|PubMed:15769782, ECO:0000269|PubMed:21846512}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Cardiomyopathy, familial restrictive 3 (RCM3) [MIM:612422]: A heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function. {ECO:0000269|PubMed:16651346}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
uniprot
proteins
mass_dalton
35924
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity. {ECO:0000250}.
uniprot
proteins
protein_family
Troponin T family
uniprot
proteins
pubmed
10525521
uniprot
proteins
pubmed
11034944
uniprot
proteins
pubmed
11106718
uniprot
proteins
pubmed
11684629
uniprot
proteins
pubmed
12707239
uniprot
proteins
pubmed
12840750
uniprot
proteins
pubmed
12974739
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15542288
uniprot
proteins
pubmed
15563892
uniprot
proteins
pubmed
15769782
uniprot
proteins
pubmed
16199542
uniprot
proteins
pubmed
16651346
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21846512
uniprot
proteins
pubmed
7498159
uniprot
proteins
pubmed
7534662
uniprot
proteins
pubmed
7895342
uniprot
proteins
pubmed
7898523
uniprot
proteins
pubmed
8088824
uniprot
proteins
pubmed
8205619
uniprot
proteins
pubmed
8344420
uniprot
proteins
pubmed
8576938
uniprot
proteins
pubmed
8989109
uniprot
proteins
pubmed
9060892
uniprot
proteins
pubmed
9140840
uniprot
proteins
pubmed
9482583
uniprot
proteins
pubmed
9689598
uniprot
proteins
sequence_length
298
uniprot
proteins