Supv3l1
entrez
294385
canonical
uniprot
Q5EBA1
canonical
ensembl
ENSRNOG00000000392
resolver
ensembl
ENSRNOG00055014607
resolver
ensembl
ENSRNOG00060007530
resolver
ensembl
ENSRNOG00065003251
resolver
ensp
ENSRNOP00000075096
resolver
ensp
ENSRNOP00055020489
resolver
ensp
ENSRNOP00060009386
resolver
ensp
ENSRNOP00065003327
resolver
enst
ENSRNOT00000080773
resolver
enst
ENSRNOT00055025059
resolver
enst
ENSRNOT00060012415
resolver
enst
ENSRNOT00065004628
resolver
genesymbol
Supv3l1
resolver
uniprot_entry
SUV3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Helicase activity toward DNA substrate is inhibited by micromolar concentrations of 5,6-dichloro-1-(beta-D-ribofuranosyl)benzotriazole (DRBT) and 4,5,6,7-tetrabromobenzotriazole (TBBT). Helicase activity toward RNA substrate is inhibited by elevated concentrations of TBBT. Inhibited by some ring-expanded nucleoside analogs. {ECO:0000250|UniProtKB:Q8IYB8}.
uniprot
proteins
amino_acid_sequence
MSLPRCALLWARLPAGRGAGPRAAPCSALRALVGSFPGASGRVPCLAASSSASGGSKAPNTSLFVPLTVKPQGPSADGDVGAELTRPLDKNEVKKILDKFYKRQEIQKLSADYGLDARLFHQAFISFRNYIMQSHSLDVDIHIVLNDICFSAAHVDDLFPFFLRHAKQIFPVLECKDDLRQISDLRRPPNWYPEARAIQRKIIFHSGPTNSGKTYHAIQRYLSATSGVYCGPLKLLAHEIFEKSNAAGVPCDLVTGEERLTVEPEGKQATHVSCTVEMCNVATPYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEVHLCGESAAIDLVTELLYTTGEEVEVQKYERLTPISVLDRALESLDNLRPGDCIVCFSKNDIYSVSRQIEIRGLESAVIYGSLPPGTKLAQARKFNDPNDPCKILVATDAIGMGLNLSIRRIIFYSLIKPSINEKGEKELEPITTSQALQIAGRAGRFSSHFKEGEVTTMHRDDLALLKEILNRPVDPIQAAGLHPTAEQIEMFAYHLPETTLSNLIDIFVDFAQVDGQYFVCNMDDFKFSAELIQHIPLSLRVRYVFCTAPINKKQPFVCSSLLQFARQYSRNEPLTFAWLRRYIKWPLLPPKNIKDLMDLEAVHDVFDLYLWLSYRFIDMFPDSSFVRSLQKELDVIIQEGVHNITKLIKISESHKLLNLEPSGSQSRLPGASKSPARRTRGTKTGNKAAEPPSPSDKELPLASRLVQQGLLTADMLKQLQKEWLTQRPEQGKEKVGTRRKKKDPNSD
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. {ECO:0000250|UniProtKB:Q8IYB8}.
uniprot
proteins
mass_dalton
86706
uniprot
proteins
protein_family
Helicase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
776
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8IYB8}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q8IYB8}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:Q8IYB8}.
uniprot
proteins