PIK3R6
entrez
146850
canonical
uniprot
Q5UE93
canonical
ensembl
ENSG00000276231
resolver
ensp
ENSP00000480157
resolver
ensp
ENSP00000577511
resolver
ensp
ENSP00000577512
resolver
enst
ENST00000619866
resolver
genesymbol
PIK3R6
resolver
genesymbol_syn
C17orf38
resolver
hgnc
HGNC:27101
resolver
uniprot
B3KRK9
resolver
uniprot
Q658R3
resolver
uniprot_entry
B3KRK9_HUMAN
resolver
uniprot_entry
PI3R6_HUMAN
resolver
uniprot_sec
Q658R3
resolver
amino_acid_sequence
MESSDVELDLQRSVQAVLRELSTQAPALQSNQGMWRWSLHKKVERDPGKSPVLVRILLRELEKAESQDLRHVIIPLLHTVMYVLTKATGITEELYQRIYAFCTRLLTLPTPYCTVALDCAIRLKTEMAVPGTLYQRMVIAEQNLTNELYPYQERVFLFVDPELVSASVCSALLLEIEAAQAQQTPETCMRHVVSHALQAALGEACHAGALHRKLQASPRRTLEHYFHAVVAALEQMASEASPSREGHVERLEEIYCSLLGPAAGRCGGDLVQERPPSIPLPSPYITFHLWTGEEQLWKELVLFLRPRSQLRLSADLEVLDLQGLRPDRELARVSVLSTDSGIERDLPTGADELPAPGSPEMERAGLQRKGGIKKRAWPLDFLMPGSWDGPPGLHRRTGRPSGDGEMLPGVSRLHTARVLVLGDDRMLGRLAQAYHRLRKRETQKFCLTPRLSLQLYYIPVLAPEKPAASRQPELGELATFLGRVDPWYQSNVNTLCPAIHKLAEMPPSLDTSRTVDPFILDVITYYIRMGTQPIYFQIYTVKIFFSDLSQDPTEDIFLIELKVKIQDSKFPKDGFSPRRRGVAEGPGAELSLCYQKALLSHRPREVTVSLRATGLILKAIPASDTEVSGSSHCPLPAAPVTDHTCLNVNVTEVVKSSNLAGKSFSTVTNTFRTNNIQIQSRDQRLLTLSLDKDDQRTFRDVVRFEVAPCPEPCSGAQKSKAPWLNLHGQQEVEAIKAKPKPLLMPINTFSGIVQ
uniprot
proteins
function
FUNCTION: Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. {ECO:0000269|PubMed:21393242}.
uniprot
proteins
mass_dalton
84258
uniprot
proteins
pubmed
16476736
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21393242
uniprot
proteins
sequence_length
754
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3U6Q4}. Cell membrane {ECO:0000250|UniProtKB:Q3U6Q4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q3U6Q4}. Note=Translocated to the plasma membrane in a Ras-dependent manner. {ECO:0000250|UniProtKB:Q3U6Q4}.
uniprot
proteins