N4bp1
entrez
80750
canonical
uniprot
Q6A037
canonical
ensembl
ENSMUSG00000031652
resolver
ensp
ENSMUSP00000034074
resolver
ensp
ENSMUSP00000294656
resolver
ensp
ENSMUSP00000294658
resolver
enst
ENSMUST00000034074
resolver
genesymbol
N4bp1
resolver
genesymbol_syn
BC004022
resolver
genesymbol_syn
Kiaa0615
resolver
uniprot
Q3TCI4
resolver
uniprot
Q3UH87
resolver
uniprot
Q3UY69
resolver
uniprot
Q5EBQ4
resolver
uniprot_entry
N4BP1_MOUSE
resolver
uniprot_entry
Q5EBQ4_MOUSE
resolver
uniprot_sec
Q3TCI4
resolver
uniprot_sec
Q3UH87
resolver
uniprot_sec
Q3UY69
resolver
activity_regulation
ACTIVITY REGULATION: Proteolytic cleavage by CASP8 or MALT1 leads to its inactivation. {ECO:0000269|PubMed:32971525}.
uniprot
proteins
amino_acid_sequence
MAARVVLDEFTAPAEKAALLERSRGRIEALFGVGLAVLGALGAEEPLPARIWLQLRGAQEAVHSAKEYIKGICEPELEEKECYPKAMHCIFVGAQSLFLKSLIQDTCADLCVLDTGLLGIRGSAEAVVMARSHIQQFVKLFESNENLPSNQRESEIKREFRQFVEAHADSYTMDLLILPTSLKKELLSLTQGEESLFETDDDVITVGDVRPPEYTQSAATGPSSARDEVVVQEDSRNKARTPVSELTKHMDTVFSSSPDVLFVPVNGLSPDEDALSKDRVCHKRRSSDTEERHTKKQFSLENVPEGELLPDGKGSAGNEVIDLSDPASNSTNLSPDGKDTTEEMEYNILVNFFKTMGYSQEIVEKVIREYGPSTEPLLLLEEIEKENKRLQEDRDFPPCTVYPDASQSRNAGVGSTTNELTADSTPKKAQSHTEQSMVERFSQLPFKDSKHCTSNCKVNSFRTVPVGQKQEIWGSKQNSSCTVDLETDGHSASAASASPKDISFVSRGASGHQQRNPAFPENGFQQQTEPLLPNNTKPACEKRSGSCSSPQPKPNYPPLSPPLPLPQLLPSVTEARLGGSSDHIDSSVTGVQRFRDTLKIPYKLELKNEPGRADLKHIVIDGSNVAITHGLKKFFSCRGIAIAVEYFWKLGNRNITVFVPQWRTRRDPNITEQHFLTQLQELGILSLTPARMVFGERIASHDDRFLLHLADKTGGIIVTNDNFREFVTESVSWREIITKRLLQYTFVGDIFMVPDDPLGRNGPRLEEFLRKEAFLRHMQPLLNALPSVGTFDPGFRSPSTQVANNSHQPPPRIQTSSSPWLPQQSHFTALATLPSMQQNPPLPAQRSSAETSELREALLKIFPDSEQKLKIDQILAAHPYMKDLNALSALVLD
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation (PubMed:32971525). Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults (PubMed:32971525). In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (PubMed:32971525). Acts as a restriction factor against some viruses: restricts viral replication by binding to mRNA viruses and mediating their degradation via its ribonuclease activity (By similarity). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (PubMed:17592138). {ECO:0000250|UniProtKB:O75113, ECO:0000269|PubMed:17592138, ECO:0000269|PubMed:32971525}.
uniprot
proteins
mass_dalton
99147
uniprot
proteins
mutagenesis
MUTAGEN 488; /note="D->A: Prevents cleavage by CASP8 and subsequent inactivation."; /evidence="ECO:0000269|PubMed:32971525
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation (PubMed:32971525). Mainly cleaved at Asp-488 by CASP8 (PubMed:32971525). Cleaved by caspase-like protein MALT1, leading to its inactivation (By similarity). {ECO:0000250|UniProtKB:O75113, ECO:0000269|PubMed:32971525}.; PTM: Mono- and polyubiquitinated on the CoCUN region (By similarity). Monoubiquitinated by NEDD4 (PubMed:11717310). Polyubiquitinated, leading to its degradation by the proteasome (PubMed:20233849). Sumoylated with SUMO1, abrogating polyubiquitination and subsequent degradation (PubMed:20233849). Desumoylated by SENP1, leading to accumulation in PML nuclear bodies (PubMed:20233849). {ECO:0000250|UniProtKB:O75113, ECO:0000269|PubMed:11717310, ECO:0000269|PubMed:20233849}.
uniprot
proteins
protein_family
N4BP1 family
uniprot
proteins
pubmed
11717310
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17592138
uniprot
proteins
pubmed
20233849
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32971525
uniprot
proteins
sequence_length
893
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:32971525}. Nucleus {ECO:0000269|PubMed:11717310}. Nucleus, nucleolus {ECO:0000269|PubMed:20233849}. Nucleus, PML body {ECO:0000269|PubMed:20233849}. Note=Primarily localizes to the nucleolus (PubMed:20233849). Also localizes to the PML nuclear bodies, when desumoylated (PubMed:20233849). {ECO:0000269|PubMed:20233849}.
uniprot
proteins