ALOX15
entrez
246
canonical
uniprot
P16050
canonical
ensembl
ENSG00000161905
resolver
ensp
ENSP00000293761
resolver
genesymbol
ALOX15
resolver
genesymbol_syn
LOG15
resolver
hgnc
HGNC:433
resolver
uniprot
A8K2P4
resolver
uniprot
B7ZA11
resolver
uniprot
Q8N6R7
resolver
uniprot
Q99657
resolver
uniprot_entry
LOX15_HUMAN
resolver
uniprot_sec
A8K2P4
resolver
uniprot_sec
B7ZA11
resolver
uniprot_sec
Q8N6R7
resolver
uniprot_sec
Q99657
resolver
activity_regulation
ACTIVITY REGULATION: Activity is increased by binding phosphatidylinositol phosphates, especially phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate (PubMed:17052953). Inactivated at 37 degrees Celsius by (13S)-hydroperoxy-(9Z,11E)-octadecadienoate (PubMed:8334154). {ECO:0000269|PubMed:17052953, ECO:0000269|PubMed:8334154}.
uniprot
proteins
amino_acid_sequence
MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMSTGGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVSLHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQHASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQPVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSVAI
uniprot
proteins
disease_involvement
DISEASE: Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry. Met at position 560 may confer interindividual susceptibility to coronary artery disease (CAD) (PubMed:17959182). {ECO:0000269|PubMed:17959182}.
uniprot
proteins
ec_number
1.13.11.-
uniprot
proteins
ec_number
1.13.11.12
uniprot
proteins
ec_number
1.13.11.31
uniprot
proteins
ec_number
1.13.11.33
uniprot
proteins
function
FUNCTION: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:17052953, PubMed:1944593, PubMed:24282679, PubMed:25293588, PubMed:32404334, PubMed:8334154). It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE (PubMed:17052953, PubMed:1944593, PubMed:24282679, PubMed:8334154). It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties (By similarity). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (PubMed:8334154). May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets (PubMed:32404334). Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (PubMed:25293588). Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response. In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties. Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells. It is also implicated in the generation of endogenous ligands for peroxisome proliferator activated receptor (PPAR-gamma), hence modulating macrophage development and function. It may also exert a negative effect on skeletal development by regulating bone mass through this pathway. As well as participates in ER stress and downstream inflammation in adipocytes, pancreatic islets, and liver (By similarity). Finally, it is also involved in the cellular response to IL13/interleukin-13 (PubMed:21831839). {ECO:0000250|UniProtKB:P39654, ECO:0000250|UniProtKB:Q02759, ECO:0000269|PubMed:17052953, ECO:0000269|PubMed:1944593, ECO:0000269|PubMed:21831839, ECO:0000269|PubMed:24282679, ECO:0000269|PubMed:25293588, ECO:0000269|PubMed:32404334, ECO:0000269|PubMed:8334154}.
uniprot
proteins
mass_dalton
74804
uniprot
proteins
mutagenesis
MUTAGEN 418; /note="M->V: Catalyzes 15- and 12-lipoxygenation."; /evidence="ECO:0000269|PubMed:1944593
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. {ECO:0000269|PubMed:1944593}.
uniprot
proteins
protein_family
Lipoxygenase family
uniprot
proteins
pubmed
11418015
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
1662607
uniprot
proteins
pubmed
17052953
uniprot
proteins
pubmed
17959182
uniprot
proteins
pubmed
18755188
uniprot
proteins
pubmed
1944593
uniprot
proteins
pubmed
19528634
uniprot
proteins
pubmed
21831839
uniprot
proteins
pubmed
23242647
uniprot
proteins
pubmed
24282679
uniprot
proteins
pubmed
25293588
uniprot
proteins
pubmed
3202857
uniprot
proteins
pubmed
32404334
uniprot
proteins
pubmed
3356688
uniprot
proteins
pubmed
8334154
uniprot
proteins
pubmed
9224951
uniprot
proteins
pubmed
9414270
uniprot
proteins
pubmed
9700053
uniprot
proteins
sequence_length
662
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17052953, ECO:0000269|PubMed:21831839}. Cell membrane {ECO:0000269|PubMed:21831839}; Peripheral membrane protein {ECO:0000269|PubMed:17052953}. Lipid droplet {ECO:0000269|PubMed:19528634}. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding (By similarity). Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells (By similarity). {ECO:0000250|UniProtKB:P39654}.
uniprot
proteins