Brcc3
entrez
316794
canonical
uniprot
B2RYM5
canonical
ensembl
ENSRNOG00000048061
resolver
ensembl
ENSRNOG00055016606
resolver
ensembl
ENSRNOG00060026217
resolver
ensembl
ENSRNOG00065014364
resolver
ensp
ENSRNOP00000066438
resolver
ensp
ENSRNOP00000101704
resolver
ensp
ENSRNOP00000111886
resolver
ensp
ENSRNOP00055022699
resolver
ensp
ENSRNOP00060037676
resolver
ensp
ENSRNOP00065018454
resolver
enst
ENSRNOT00000071068
resolver
enst
ENSRNOT00000127736
resolver
enst
ENSRNOT00000147895
resolver
enst
ENSRNOT00055028197
resolver
enst
ENSRNOT00060045378
resolver
enst
ENSRNOT00065023702
resolver
genesymbol
Brcc3
resolver
genesymbol_syn
Brcc36
resolver
uniprot_entry
BRCC3_RAT
resolver
amino_acid_sequence
MAVPVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDVRSESKFAHAGSDVCTVPEKVDSIRVVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSVQAQKSSDYERIEIPVHVVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLRELQREKEELMAELRSLE
uniprot
proteins
ec_number
3.4.19.-
uniprot
proteins
function
FUNCTION: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (By similarity). Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of NLRP3, leading to NLRP3 inflammasome assembly (By similarity). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (By similarity). Deubiquitinates HDAC1 and PWWP2B leading to their stabilization (By similarity). {ECO:0000250|UniProtKB:P46736, ECO:0000250|UniProtKB:P46737}.
uniprot
proteins
mass_dalton
33016
uniprot
proteins
protein_family
BRCC36 subfamily
uniprot
proteins
protein_family
Peptidase M67A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P46736}. Cytoplasm {ECO:0000250|UniProtKB:P46736}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P46736}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). Interaction with ABRAXAS2 retains BRCC3 in the cytoplasm. {ECO:0000250|UniProtKB:P46736}.
uniprot
proteins