ELOVL7
entrez
79993
canonical
uniprot
A1L3X0
canonical
ensembl
ENSG00000164181
resolver
ensp
ENSP00000402634
resolver
ensp
ENSP00000421043
resolver
ensp
ENSP00000424123
resolver
ensp
ENSP00000536696
resolver
ensp
ENSP00000536697
resolver
enst
ENST00000425382
resolver
enst
ENST00000505959
resolver
enst
ENST00000508821
resolver
enst
ENST00000866637
resolver
enst
ENST00000866638
resolver
genesymbol
ELOVL7
resolver
hgnc
HGNC:26292
resolver
uniprot
D6RHD0
resolver
uniprot
Q589T3
resolver
uniprot
Q9H5D0
resolver
uniprot
Q9NT66
resolver
uniprot_entry
D6RHD0_HUMAN
resolver
uniprot_entry
ELOV7_HUMAN
resolver
uniprot_sec
Q589T3
resolver
uniprot_sec
Q9H5D0
resolver
uniprot_sec
Q9NT66
resolver
amino_acid_sequence
MAFSDLTSRTVHLYDNWIKDADPRVEDWLLMSSPLPQTILLGFYVYFVTSLGPKLMENRKPFELKKAMITYNFFIVLFSVYMCYEFVMSGWGIGYSFRCDIVDYSRSPTALRMARTCWLYYFSKFIELLDTIFFVLRKKNSQVTFLHVFHHTIMPWTWWFGVKFAAGGLGTFHALLNTAVHVVMYSYYGLSALGPAYQKYLWWKKYLTSLQLVQFVIVAIHISQFFFMEDCKYQFPVFACIIMSYSFMFLLLFLHFWYRAYTKGQRLPKTVKNGTCKNKDN
uniprot
proteins
ec_number
2.3.1.199
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000255|HAMAP-Rule:MF_03207, ECO:0000269|PubMed:19826053, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:21959040, ECO:0000269|PubMed:34117479}.
uniprot
proteins
mass_dalton
33356
uniprot
proteins
mutagenesis
MUTAGEN 150; /note="H->A: Loss of activity alone or when associated with A-151."; /evidence="ECO:0000269|PubMed:21959040, ECO:0000269|PubMed:34117479"; MUTAGEN 151; /note="H->A: Loss of activity; when associated with A-150."; /evidence="ECO:0000269|PubMed:21959040
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03207, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:21959040}.
uniprot
proteins
protein_family
ELO family
uniprot
proteins
protein_family
ELOVL7 subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19826053
uniprot
proteins
pubmed
20937905
uniprot
proteins
pubmed
21959040
uniprot
proteins
pubmed
34117479
uniprot
proteins
pubmed
38422897
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03207, ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03207}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..48; /note="Helical; Name=1"; /evidence="ECO:0000255|HAMAP-Rule:MF_03207"; TRANSMEM 73..93; /note="Helical; Name=2"; /evidence="ECO:0000255|HAMAP-Rule:MF_03207"; TRANSMEM 116..136; /note="Helical; Name=3"; /evidence="ECO:0000255|HAMAP-Rule:MF_03207"; TRANSMEM 143..162; /note="Helical; Name=4"; /evidence="ECO:0000255|HAMAP-Rule:MF_03207"; TRANSMEM 172..194; /note="Helical; Name=5"; /evidence="ECO:0000255|HAMAP-Rule:MF_03207"; TRANSMEM 207..227; /note="Helical; Name=6"; /evidence="ECO:0000255|HAMAP-Rule:MF_03207"; TRANSMEM 237..257; /note="Helical; Name=7"; /evidence="ECO:0000255|HAMAP-Rule:MF_03207
uniprot
proteins