Cep55
entrez
294074
canonical
uniprot
Q4V7C8
canonical
ensembl
ENSRNOG00000016377
resolver
ensp
ENSRNOP00000022133
resolver
genesymbol
Cep55
resolver
uniprot_entry
CEP55_RAT
resolver
amino_acid_sequence
MSSRSPKDLIKSKWGSRPSSSKSDTALEKFKGEIAAFKTSLDEITNGKGKVANKDRSKLLEKIQVLEAEREKNVYYLMEKDKEIQRLKDHLRSRYSSSSLLEQLEEKTKECEKKQQLLESLSRETDILKKQLSATTKRLSELESKASTLHLSQSVPANCFNSSMNSIHEKEMQLKDALEKNQQWLVYDQQREAYVKGLLAKIFELEKRTETAAASLPQQMKKTESEGYLQEEKQKYDHLLENAKKDLEVERQTVTQLRLELDEFRRKYEETQKEVEDLNQLLSSQRKADIQHLEEDKHKTEKIQKLREESSVFKGKLEEERKKSEELLSQVRILYDSLLKHQEEQSRVALLERQMQACTLDFENEKLDRQNMQHQLYVILKELRKAKSQITQLESLKQLHGFTFTEQPFPLQGEPENRVKATSPKSPTAVLNESLVECPKCSVQYPATEHRDLLVHVEYCMK
uniprot
proteins
function
FUNCTION: Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney. {ECO:0000250|UniProtKB:Q53EZ4}.
uniprot
proteins
mass_dalton
53995
uniprot
proteins
post_translational_modification
PTM: There is a hierachy of phosphorylation, where both Ser-423 and Ser-426 are phosphorylated at the onset of mitosis, prior to Ser-434. Phosphorylation at Ser-423 and Ser-426 is required for dissociation from the centrosome at the G2/M boundary. Phosphorylation at the 3 sites, Ser-423, Ser-426 and Ser-434, is required for protein function at the final stages of cell division to complete cytokinesis successfully (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q53EZ4}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q53EZ4}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q53EZ4}. Cleavage furrow {ECO:0000250|UniProtKB:Q53EZ4}. Midbody, Midbody ring {ECO:0000250|UniProtKB:Q53EZ4}. Midbody {ECO:0000250|UniProtKB:Q53EZ4}. Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loses affinity for the centrosome at the onset of prophase and diffuses throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis. {ECO:0000250|UniProtKB:Q53EZ4}.
uniprot
proteins