Psmc3ip
entrez
19183
canonical
uniprot
O35047
canonical
ensembl
ENSMUSG00000019303
resolver
ensp
ENSMUSP00000019447
resolver
enst
ENSMUST00000019447
resolver
genesymbol
Psmc3ip
resolver
genesymbol_syn
Hop2
resolver
genesymbol_syn
Tbpip
resolver
uniprot
C4PFH5
resolver
uniprot
Q3V035
resolver
uniprot_entry
C4PFH5_MOUSE
resolver
uniprot_entry
HOP2_MOUSE
resolver
uniprot_sec
Q3V035
resolver
amino_acid_sequence
MSKSRAEAAAGAPGIILRYLQEQNRPYSAQDVFGNLQKEHGLGKAAVVKALDQLAQEGKIKEKTYGKQKIYFADQNQFDTVSDADLHGLDASIVALTAKVQSLQQSCRHMEAELKELTSALTTPEMQKEIQELKKECAQYTERLKNIKAATNHVTPEEKEKVYRDRQKYCKEWRKRKRMTTELCDAILEGYPKSKKQFFEEVGIETDEDHNVLLPDP
uniprot
proteins
function
FUNCTION: Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. {ECO:0000269|PubMed:15192114, ECO:0000269|PubMed:16675459, ECO:0000269|PubMed:17426123, ECO:0000269|PubMed:17639080, ECO:0000269|PubMed:17639081, ECO:0000269|PubMed:9345291}.
uniprot
proteins
mass_dalton
24748
uniprot
proteins
mutagenesis
MUTAGEN 136; /note="E->P: Alters PSMC3/MND1 formation."; /evidence="ECO:0000269|PubMed:16675459
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA, PKC and MAPK. {ECO:0000250}.
uniprot
proteins
protein_family
HOP2 family
uniprot
proteins
pubmed
11739747
uniprot
proteins
pubmed
14667414
uniprot
proteins
pubmed
15192114
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16675459
uniprot
proteins
pubmed
17426123
uniprot
proteins
pubmed
17639080
uniprot
proteins
pubmed
17639081
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9345291
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11739747}.
uniprot
proteins