GPER
entrez
2852
canonical
uniprot
Q99527
canonical
ensembl
ENSG00000164850
resolver
ensp
ENSP00000297469
resolver
ensp
ENSP00000380277
resolver
ensp
ENSP00000380281
resolver
ensp
ENSP00000385151
resolver
ensp
ENSP00000523563
resolver
ensp
ENSP00000523564
resolver
ensp
ENSP00000523565
resolver
ensp
ENSP00000523566
resolver
ensp
ENSP00000523567
resolver
ensp
ENSP00000523568
resolver
ensp
ENSP00000523569
resolver
ensp
ENSP00000523570
resolver
ensp
ENSP00000523571
resolver
ensp
ENSP00000523572
resolver
ensp
ENSP00000634633
resolver
ensp
ENSP00000634634
resolver
enst
ENST00000297469
resolver
enst
ENST00000397088
resolver
enst
ENST00000397092
resolver
enst
ENST00000401670
resolver
enst
ENST00000853504
resolver
enst
ENST00000853505
resolver
enst
ENST00000853506
resolver
enst
ENST00000853507
resolver
enst
ENST00000853508
resolver
enst
ENST00000853509
resolver
enst
ENST00000853510
resolver
enst
ENST00000853511
resolver
enst
ENST00000853512
resolver
enst
ENST00000853513
resolver
enst
ENST00000964574
resolver
enst
ENST00000964575
resolver
genesymbol
GPER
resolver
genesymbol
GPER1
resolver
genesymbol_syn
CEPR
resolver
genesymbol_syn
CMKRL2
resolver
genesymbol_syn
DRY12
resolver
genesymbol_syn
GPER
resolver
genesymbol_syn
GPR30
resolver
hgnc
HGNC:4485
resolver
uniprot
A8K6C5
resolver
uniprot
B5BUJ1
resolver
uniprot
O00143
resolver
uniprot
O43494
resolver
uniprot
Q13631
resolver
uniprot
Q63ZY2
resolver
uniprot
Q6FHL1
resolver
uniprot
Q96F42
resolver
uniprot
Q99981
resolver
uniprot_entry
GPER1_HUMAN
resolver
uniprot_entry
Q63ZY2_HUMAN
resolver
uniprot_sec
A8K6C5
resolver
uniprot_sec
B5BUJ1
resolver
uniprot_sec
O00143
resolver
uniprot_sec
O43494
resolver
uniprot_sec
Q13631
resolver
uniprot_sec
Q6FHL1
resolver
uniprot_sec
Q96F42
resolver
uniprot_sec
Q99981
resolver
amino_acid_sequence
MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV
uniprot
proteins
function
FUNCTION: G protein-coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Also functions as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells. {ECO:0000269|PubMed:11043579, ECO:0000269|PubMed:15539556, ECO:0000269|PubMed:15705806, ECO:0000269|PubMed:19179659, ECO:0000269|PubMed:19342448, ECO:0000269|PubMed:20203690, ECO:0000269|PubMed:20551055, ECO:0000269|PubMed:21149639, ECO:0000269|PubMed:21242460, ECO:0000269|PubMed:21427217, ECO:0000269|PubMed:23135268, ECO:0000269|PubMed:23283935, ECO:0000269|PubMed:23285008, ECO:0000269|PubMed:23674134}.
uniprot
proteins
mass_dalton
42248
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; ubiquitination occurs at the plasma membrane and leads to proteasome-mediated degradation. {ECO:0000269|PubMed:21540189}.; PTM: Glycosylated. {ECO:0000269|PubMed:21427217}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11043579
uniprot
proteins
pubmed
12027886
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15539556
uniprot
proteins
pubmed
15705806
uniprot
proteins
pubmed
16645038
uniprot
proteins
pubmed
17379646
uniprot
proteins
pubmed
18566127
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
19179659
uniprot
proteins
pubmed
19342448
uniprot
proteins
pubmed
19749156
uniprot
proteins
pubmed
19931550
uniprot
proteins
pubmed
20203690
uniprot
proteins
pubmed
20551055
uniprot
proteins
pubmed
21149639
uniprot
proteins
pubmed
21242460
uniprot
proteins
pubmed
21354433
uniprot
proteins
pubmed
21427217
uniprot
proteins
pubmed
21540189
uniprot
proteins
pubmed
22495674
uniprot
proteins
pubmed
22521564
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23135268
uniprot
proteins
pubmed
23283935
uniprot
proteins
pubmed
23285008
uniprot
proteins
pubmed
23674134
uniprot
proteins
pubmed
8920907
uniprot
proteins
pubmed
9070864
uniprot
proteins
pubmed
9141481
uniprot
proteins
pubmed
9367686
uniprot
proteins
pubmed
9398636
uniprot
proteins
pubmed
9479505
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18566127}; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Postsynaptic density {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalized with BSN to the active zone of presynaptic density. Colocalized with DLG4/PSD95 and neurabin-2 PPP1R9B in neuronal synaptosomes (By similarity). Endocytosed in a agonist- and arrestin-independent manner. Colocalized with RAMP3 and clathrin-coated pits at the plasma membrane. Colocalized with transferrin receptor at the plasma membrane and perinuclear region. Accumulated and colocalized with RAB11 proteins in recycling endosomes and trans-Golgi network (TGN), but does neither recycle back to the cell surface nor traffics to late endosome or lysosome. Colocalized with calnexin in the endoplasmic reticulum. Traffics to intracellular sites via cytokeratin intermediate filaments like KRT7 and KRT8 after constitutive endocytosis in epithelial cells. Colocalized with EGFR in the nucleus of agonist-induced cancer-associated fibroblasts (CAF). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 63..84; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 97..120; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 133..153; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 176..194; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 221..236; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 307..327; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins