LGALS9
entrez
3965
canonical
uniprot
O00182
canonical
ensembl
ENSG00000168961
resolver
ensp
ENSP00000306228
resolver
ensp
ENSP00000318214
resolver
ensp
ENSP00000378856
resolver
ensp
ENSP00000540823
resolver
ensp
ENSP00000653078
resolver
ensp
ENSP00000799380
resolver
genesymbol
LGALS9
resolver
hgnc
HGNC:6570
resolver
uniprot
A7VJG6
resolver
uniprot
F8W9W4
resolver
uniprot
O14532
resolver
uniprot
O75028
resolver
uniprot
Q3B8N1
resolver
uniprot
Q53FQ0
resolver
uniprot
Q8WYQ7
resolver
uniprot
Q9NQ58
resolver
uniprot_entry
LEG9_HUMAN
resolver
uniprot_sec
A7VJG6
resolver
uniprot_sec
F8W9W4
resolver
uniprot_sec
O14532
resolver
uniprot_sec
O75028
resolver
uniprot_sec
Q3B8N1
resolver
uniprot_sec
Q53FQ0
resolver
uniprot_sec
Q8WYQ7
resolver
uniprot_sec
Q9NQ58
resolver
amino_acid_sequence
MAFSGSQAPYLSPAVPFSGTIQGGLQDGLQITVNGTVLSSSGTRFAVNFQTGFSGNDIAFHFNPRFEDGGYVVCNTRQNGSWGPEERKTHMPFQKGMPFDLCFLVQSSDFKVMVNGILFVQYFHRVPFHRVDTISVNGSVQLSYISFQNPRTVPVQPAFSTVPFSQPVCFPPRPRGRRQKPPGVWPANPAPITQTVIHTVQSAPGQMFSTPAIPPMMYPHPAYPMPFITTILGGLYPSKSILLSGTVLPSAQRFHINLCSGNHIAFHLNPRFDENAVVRNTQIDNSWGSEERSLPRKMPFVRGQSFSVWILCEAHCLKVAVDGQHLFEYYHRLRNLPTINRLEVGGDIQLTHVQT
uniprot
proteins
function
FUNCTION: Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PubMed:23817958). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (PubMed:20209097). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (PubMed:16116184, PubMed:24465902). Inhibits degranulation and induces apoptosis of mast cells (PubMed:24465902). Induces maturation and migration of dendritic cells (PubMed:16116184, PubMed:25754930). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (PubMed:25578313). Astrocyte derived galectin-9 enhances microglial TNF production (By similarity). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity). {ECO:0000250|UniProtKB:O08573, ECO:0000250|UniProtKB:P97840, ECO:0000269|PubMed:16116184, ECO:0000269|PubMed:16286920, ECO:0000269|PubMed:18005988, ECO:0000269|PubMed:18977853, ECO:0000269|PubMed:20209097, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:23408620, ECO:0000269|PubMed:23817958, ECO:0000269|PubMed:24465902, ECO:0000269|PubMed:25578313, ECO:0000269|PubMed:25754930}.; FUNCTION: [Isoform 2]: Acts as an eosinophil chemoattractant (PubMed:9642261). It also inhibits angiogenesis (PubMed:24333696). Suppresses IFNG production by natural killer cells (By similarity). {ECO:0000250|UniProtKB:O08573, ECO:0000269|PubMed:24333696, ECO:0000269|PubMed:9642261}.
uniprot
proteins
mass_dalton
39518
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16116184
uniprot
proteins
pubmed
16286920
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18005988
uniprot
proteins
pubmed
18977853
uniprot
proteins
pubmed
20209097
uniprot
proteins
pubmed
20861009
uniprot
proteins
pubmed
21670307
uniprot
proteins
pubmed
23242525
uniprot
proteins
pubmed
23408620
uniprot
proteins
pubmed
23817958
uniprot
proteins
pubmed
24333696
uniprot
proteins
pubmed
24465902
uniprot
proteins
pubmed
24786365
uniprot
proteins
pubmed
25578313
uniprot
proteins
pubmed
25754930
uniprot
proteins
pubmed
9045665
uniprot
proteins
pubmed
9642261
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23242525}. Nucleus {ECO:0000269|PubMed:23242525}. Secreted {ECO:0000269|PubMed:23817958, ECO:0000269|PubMed:25578313}. Note=May also be secreted by a non-classical secretory pathway (By similarity). Secreted by mesenchymal stromal cells upon IFNG stimulation (PubMed:23817958). {ECO:0000250|UniProtKB:O08573, ECO:0000269|PubMed:23817958}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:24333696}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:24333696}.
uniprot
proteins