Atp6v1e1
entrez
297566
canonical
uniprot
Q6PCU2
canonical
ensembl
ENSRNOG00000011905
resolver
ensp
ENSRNOP00000016495
resolver
enst
ENSRNOT00000016495
resolver
genesymbol
Atp6v1e1
resolver
uniprot
G3V7L8
resolver
uniprot_entry
G3V7L8_RAT
resolver
uniprot_entry
VATE1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: V-ATPase activity on lysosomes is inhibited in response to calorie restriction: deacetylated by SIRT1 downstream of TULP3, leading to (1) V-ATPase complex inhibition on lysosomes and (2) AMP-activated protein kinase (AMPK) activation via the AXIN1-STK11/LKB1 axis. {ECO:0000250|UniProtKB:P50518}.
uniprot
proteins
amino_acid_sequence
MALSDADVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKKDVDVQIDLEAYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRGALFGANANRKFLD
uniprot
proteins
function
FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32165585). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32165585). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). {ECO:0000250|UniProtKB:P36543, ECO:0000269|PubMed:32165585}.
uniprot
proteins
mass_dalton
26128
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-52, Lys-99 and Lys-191 regulates the activity of the V-ATPase complex. Deacetylation at Lys-52, Lys-99 and Lys-191 by SIRT1 in response to calorie restriction inhibits the V-ATPase complex on lysosomes and promotes AMPK activation via the AXIN1-STK11/LKB1 axis. {ECO:0000250|UniProtKB:P50518}.
uniprot
proteins
protein_family
V-ATPase E subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
32165585
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P36543}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:32165585}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:32165585}; Peripheral membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000250|UniProtKB:P36543}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins