Gatm
entrez
67092
canonical
uniprot
Q9D964
canonical
ensembl
ENSMUSG00000027199
resolver
ensp
ENSMUSP00000028624
resolver
enst
ENSMUST00000028624
resolver
genesymbol
Gatm
resolver
uniprot
A2AK36
resolver
uniprot
Q3U8U4
resolver
uniprot
Q3UAM0
resolver
uniprot
Q3UKD9
resolver
uniprot
Q6IU01
resolver
uniprot_entry
GATM_MOUSE
resolver
uniprot_sec
A2AK36
resolver
uniprot_sec
Q3U8U4
resolver
uniprot_sec
Q3UAM0
resolver
uniprot_sec
Q3UKD9
resolver
uniprot_sec
Q6IU01
resolver
amino_acid_sequence
MLRVRCLRGGSRGAEAVHYIGSRLGGSLTGWVQRTFQSTQAATASSRNSCAAEDKATHPLPKDCPVSSYNEWDPLEEVIVGRAENACVPPFTVEVKANTYEKYWPFYQKNGGLYFPKDHLKKAVAEVEEMCNILSMEGVTVRRPDPIDWSLKYKTPDFESTGLYSAMPRDILMVVGNEIIEAPMAWRSRFFEYRAYRSIIKDYFHRGAKWTTAPKPTMADELYDQNYPIHSVEDRHKLAAQGKFVTTEFEPCFDAADFIRAGRDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFKDPNPMHIDATFNIIGPGLVLSNPDRPCHQIDLFKKAGWTIVTPPTPVIPDDHPLWMSSKWLSMNVLMLDEKRVMVDANEVPIQKMFEKLGISTIKVNIRNANSLGGGFHCWTCDVRRRGTLQSYFD
uniprot
proteins
ec_number
2.1.4.1
uniprot
proteins
function
FUNCTION: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives (By similarity). Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (By similarity). {ECO:0000250|UniProtKB:P50440}.
uniprot
proteins
mass_dalton
48297
uniprot
proteins
pathway_participation
PATHWAY: Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 1/2. {ECO:0000250|UniProtKB:P50440}.
uniprot
proteins
protein_family
Amidinotransferase family
uniprot
proteins
pubmed
12671064
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29654216
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}.
uniprot
proteins