Pth
entrez
24694
canonical
uniprot
P04089
canonical
ensembl
ENSRNOG00000014318
resolver
ensembl
ENSRNOG00055023985
resolver
ensembl
ENSRNOG00060016614
resolver
ensembl
ENSRNOG00065029760
resolver
ensp
ENSRNOP00000019199
resolver
ensp
ENSRNOP00055033514
resolver
ensp
ENSRNOP00060022906
resolver
ensp
ENSRNOP00065042344
resolver
enst
ENSRNOT00000019199
resolver
enst
ENSRNOT00055041190
resolver
enst
ENSRNOT00060028459
resolver
enst
ENSRNOT00065051415
resolver
genesymbol
Pth
resolver
uniprot
Q63473
resolver
uniprot_entry
PTHY_RAT
resolver
uniprot_sec
Q63473
resolver
amino_acid_sequence
MMSASTMAKVMILMLAVCLLTQADGKPVKKRAVSEIQLMHNLGKHLASVERMQWLRKKLQDVHNFVSLGVQMAAREGSYQRPTKKEENVLVDGNSKSLGEGDKADVDVLVKAKSQ
uniprot
proteins
function
FUNCTION: Peptide hormone secreted by parathyroid chief cells that acts as a primary endocrine regulator of extracellular calcium and phosphate homeostasis, acting primarily on bone and kidney to maintain serum calcium levels within a narrow range. Acts by binding and activating the G protein-coupled receptor PTH1R, engaging the receptor to activate G(s)-mediated cAMP/PKA signaling and G(q)-mediated PLC/PKC signaling. In bone, acts indirectly on osteoclasts by binding PTH1R on cells of the osteoblast/osteocyte lineage, where it increases expression of TNFSF11/RANKL and decreases expression of TNFRSF11B/OPG, thereby raising the RANKL/OPG ratio and stimulating osteoclast differentiation and bone resorption. Stimulates also [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. In distal renal tubule cells, stimulates active Ca(2+) reabsorption via the adenylyl cyclase-cAMP-protein kinase A (PKA) pathway leading to the phosphorylation and activation of the calcium selective cation channel TRPV5 (By similarity). Acting on PTH1R in proximal renal tubule cells, decreases reabsorption of filtered phosphate by reducing apical abundance of SLC34A1, through a mechanism involving PTH1R-activated PKC-mediated phosphorylation of the scaffold NHERF1, causing dissociation of the NHERF1-SLC34A1 complex and subsequent clathrin-mediated endocytosis and lysosomal degradation of the cotransporter (By similarity). Activates also transcription of CYP27B1 (25-hydroxyvitamin D3 1-alpha-hydroxylase) through a cAMP/PKA/SIK2-SIK3/CRTC2 axis, thereby increasing renal synthesis of the active vitamin D metabolite 1,25-dihydroxyvitamin D(3) (By similarity). {ECO:0000250|UniProtKB:P01270, ECO:0000250|UniProtKB:Q9Z0L6}.
uniprot
proteins
mass_dalton
12722
uniprot
proteins
protein_family
Parathyroid hormone family
uniprot
proteins
pubmed
3628009
uniprot
proteins
pubmed
6321505
uniprot
proteins
pubmed
7588314
uniprot
proteins
sequence_length
115
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01270}.
uniprot
proteins