TNKS2
entrez
80351
canonical
uniprot
Q9H2K2
canonical
ensembl
ENSG00000107854
resolver
ensp
ENSP00000360689
resolver
enst
ENST00000371627
resolver
genesymbol
TNKS2
resolver
genesymbol_syn
PARP5B
resolver
genesymbol_syn
TANK2
resolver
genesymbol_syn
TNKL
resolver
hgnc
HGNC:15677
resolver
uniprot
B2RBD3
resolver
uniprot
Q9H8F2
resolver
uniprot
Q9HAS4
resolver
uniprot_entry
TNKS2_HUMAN
resolver
uniprot_sec
B2RBD3
resolver
uniprot_sec
Q9H8F2
resolver
uniprot_sec
Q9HAS4
resolver
activity_regulation
ACTIVITY REGULATION: Specifically inhibited by XAV939, a small molecule, leading to inhibit the Wnt signaling pathway by stabilizing AXIN1 and AXIN2 (PubMed:19759537). Inhibited by talazoparib (PubMed:33361107). {ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:33361107}.
uniprot
proteins
amino_acid_sequence
MSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFEREQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEGMVDG
uniprot
proteins
ec_number
2.4.2.-
uniprot
proteins
ec_number
2.4.2.30
uniprot
proteins
function
FUNCTION: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Stimulates 26S proteasome activity (PubMed:23622245). {ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:11802774, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379}.
uniprot
proteins
mass_dalton
126918
uniprot
proteins
mutagenesis
MUTAGEN 553; /note="H->D: Enhanced hydroxylation by HIF1AN."; /evidence="ECO:0000269|PubMed:21251231"; MUTAGEN 553; /note="H->N: Enhanced hydroxylation by HIF1AN."; /evidence="ECO:0000269|PubMed:21251231"; MUTAGEN 1054; /note="M->V: Loss of activity."; /evidence="ECO:0000269|PubMed:19759537
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated; this leads to degradation. Deubiquitinated by USP25; leading to stabilization (By similarity). {ECO:0000250|UniProtKB:O95271, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:21799911}.; PTM: ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. {ECO:0000269|PubMed:21478859}.; PTM: The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer. {ECO:0000269|PubMed:21251231}.
uniprot
proteins
protein_family
ARTD/PARP family
uniprot
proteins
pubmed
11205898
uniprot
proteins
pubmed
11278563
uniprot
proteins
pubmed
11294570
uniprot
proteins
pubmed
11454873
uniprot
proteins
pubmed
11739745
uniprot
proteins
pubmed
11802774
uniprot
proteins
pubmed
12080061
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
18936059
uniprot
proteins
pubmed
19759537
uniprot
proteins
pubmed
20106667
uniprot
proteins
pubmed
21251231
uniprot
proteins
pubmed
21478859
uniprot
proteins
pubmed
21799911
uniprot
proteins
pubmed
23622245
uniprot
proteins
pubmed
25043379
uniprot
proteins
pubmed
33361107
uniprot
proteins
sequence_length
1166
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome, telomere {ECO:0000305}. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.
uniprot
proteins