DCXR
entrez
51181
canonical
uniprot
Q7Z4W1
canonical
ensembl
ENSG00000169738
resolver
ensp
ENSP00000303356
resolver
ensp
ENSP00000462272
resolver
enst
ENST00000306869
resolver
genesymbol
DCXR
resolver
genesymbol_syn
SDR20C1
resolver
hgnc
HGNC:18985
resolver
uniprot
A0A384NY14
resolver
uniprot
Q9BTZ3
resolver
uniprot
Q9UHY9
resolver
uniprot_entry
A0A384NY14_HUMAN
resolver
uniprot_entry
DCXR_HUMAN
resolver
uniprot_sec
Q9BTZ3
resolver
uniprot_sec
Q9UHY9
resolver
activity_regulation
ACTIVITY REGULATION: Competitively inhibited by butanoic acid, which binds to the enzyme-NADP(+) complex (PubMed:11882650). Inhibited by 4-methyl-[1,2,3]-thiadiazole-5-carboxylic acid benzyloxyamide (MTB) and 4-methylthiophene-2-carboxylic acid N-(2,3,3-trichloroacryloyl)-hydrazide (MTT) (PubMed:15906319). {ECO:0000269|PubMed:11882650, ECO:0000269|PubMed:15906319}.
uniprot
proteins
amino_acid_sequence
MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFWAC
uniprot
proteins
disease_involvement
DISEASE: Pentosuria (PNTSU) [MIM:260800]: An inborn error of metabolism characterized by excessive urinary excretion of L-xylulose. {ECO:0000269|PubMed:11882650, ECO:0000269|PubMed:22042873, ECO:0000269|PubMed:4392213}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.1.1.10
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose (PubMed:11882650, PubMed:19337691, PubMed:40737316). Can use both NAD and NADP as cosubstrate but shows higher activity with NADP (PubMed:11882650). Participates in the uronate cycle of glucose metabolism (PubMed:11882650). May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules (PubMed:11882650). {ECO:0000269|PubMed:11882650, ECO:0000269|PubMed:19337691, ECO:0000269|PubMed:40737316, ECO:0000303|PubMed:11882650}.
uniprot
proteins
mass_dalton
25913
uniprot
proteins
mutagenesis
MUTAGEN 107; /note="N->L,D: Loss of function. Probably due to defects in formation of the active site and binding of coenzyme."; /evidence="ECO:0000269|PubMed:15103634"; MUTAGEN 138; /note="C->A: Reduces substrate affinity by 2-fold but slightly increases the catalytic efficiency."; /evidence="ECO:0000269|PubMed:19337691
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
10385429
uniprot
proteins
pubmed
11882650
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12680326
uniprot
proteins
pubmed
15103634
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15906319
uniprot
proteins
pubmed
19337691
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22042873
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
40737316
uniprot
proteins
pubmed
4392213
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q91X52}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q91X52}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q91XV4}. Note=Probably recruited to membranes via an interaction with phosphatidylinositol. {ECO:0000250|UniProtKB:Q91XV4}.
uniprot
proteins