Pirt
entrez
193003
canonical
uniprot
Q8BFY0
canonical
ensembl
ENSMUSG00000048070
resolver
ensp
ENSMUSP00000128117
resolver
ensp
ENSMUSP00000347228
resolver
enst
ENSMUST00000123434
resolver
genesymbol
Pirt
resolver
genesymbol_syn
A530088H08Rik
resolver
uniprot
Q3UFA4
resolver
uniprot_entry
PIRT_MOUSE
resolver
uniprot_entry
Q3UFA4_MOUSE
resolver
amino_acid_sequence
MEVLPKALEVDERSPESKDLLPSQTASSLCISSRSESVWTTTPKSNWEIYHKPIIIMSVGAAILLFGVAITCVAYILEEKHKVVQVLRMIGPAFLSLGLMMLVCGLVWVPIIKKKQKQRQKSNFFQSLKFFLLNR
uniprot
proteins
function
FUNCTION: Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI). {ECO:0000269|PubMed:18455988}.
uniprot
proteins
mass_dalton
15264
uniprot
proteins
mutagenesis
MUTAGEN 113..121; /note="KKKQKQRQK->AAAQAQAQA: Abolishes phosphoinositide-binding but does not affect the interaction with TRPV1."; /evidence="ECO:0000269|PubMed:18455988"; MUTAGEN 113..115; /note="KKK->QQQ: Abolishes phosphoinositide-binding and ability to activate TRPV1 without affecting the interaction with TRPV1."; /evidence="ECO:0000269|PubMed:18455988
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18455988
uniprot
proteins
sequence_length
135
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 54..74; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins