Arhgef28
entrez
110596
canonical
uniprot
P97433
canonical
ensembl
ENSMUSG00000021662
resolver
ensp
ENSMUSP00000105053
resolver
ensp
ENSMUSP00000158740
resolver
ensp
ENSMUSP00000230068
resolver
enst
ENSMUST00000238746
resolver
genesymbol
Arhgef28
resolver
genesymbol_syn
Kiaa1998
resolver
genesymbol_syn
Rgnef
resolver
genesymbol_syn
Rhoip2
resolver
genesymbol_syn
Rip2
resolver
uniprot
A0A571BEH9
resolver
uniprot
A0PJC1
resolver
uniprot
B2RQQ2
resolver
uniprot
G5E8P2
resolver
uniprot
Q69Z41
resolver
uniprot
Q6DI55
resolver
uniprot_entry
A0A571BEH9_MOUSE
resolver
uniprot_entry
ARG28_MOUSE
resolver
uniprot_sec
A0PJC1
resolver
uniprot_sec
B2RQQ2
resolver
uniprot_sec
G5E8P2
resolver
uniprot_sec
Q69Z41
resolver
uniprot_sec
Q6DI55
resolver
amino_acid_sequence
MELSCSEVPLYGQKTVYAKFGKNVYLPEDAEFYFVYGGSHQRHVVIADRVQDNVLQSSIPGHWLQETVTVSVCLCSEGYSPVTMGSGSVTYVDNMACRLARLLVTQADRLTACSHQTLLTPFALTVEALPALDEELVLALTQLELPLGWTVLGNSSLEVSLHRESLLHLAVRWALPKLFHFLLCLPGGVKALKLPNEEATTPLDLALQGGHSTLVEDITNFQGSHSPGFSRLRLNEEATLQFVHSSETLTLTVNHTAEHLLEADIKLFRKYFWDRAFLVKALEQEAKTEKATMPSGAAETEEEVRNLESGRSPSEEEEDAKSIKSQVDGPSEHEDQDRLPLDRSFDGLKKSKHVPASLAAGQLSDVLNGGDEVYANCMVIDQVGDLDINYINLEGLSTHTSPESGRSMLGPQACMHTLPPDTSPCGRPLIENSEGTLDAAASQSFVTPSSSRTSNLNLSFGLHGFEKEQSHLKKRSSSLDALVADSEGEGGSEPPICYAVGSQSSPRTGLPSGDELDSFETNTEPDCNISRTESLSLSSTLHSKESLLSGIRSRSYSCSSPKISSGKSRLVRDFTVCSTSEEQRSYSFQEPPGEKRIQEEEWDEYVIPAKSESEKYKVSRTFSFLMNRMTSPRNKSKMKNKDTKEKEKMNRHQFVPGTFSGVLQCSGCDKTLLGKESLQCANCKANTHKGCKDAVPPCTKKFQEKYNKNKPQSILGSSSVRDVPAPGLSLHPSSSMPIGLPAGRKEFAAQVHPLSRSVPGTTLESFRRAVTSLESEGDSWRSRSHSDELFQSMGSSPSTESFMMEDVVDSSLWIDLSSDAQEFEAESWSLVVDPSFCSRQEKDVIKRQDVIFELMQTEVHHIQTLLIMSEVFRKGMKEELQLDHSTVDKIFPCLDELLETHRHFFFSMKERRQESCAGSDRNFVINQIGDILVQQFSEENASKMKRIYGEFCSHHKEAMSLFKELQQNKKFQNFIKIRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHRDLCKALGLIKDMIAAVDLKVSEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALLSQERALLHDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEEGGRTSESDEERRKAEARVAKIQQCQEILSNQDQQICTYLEEKLHIYAELGELSGFEDVHLEPHLLIKPDPGEPPQAASLLAAALREAESLQVAVKASKMGDVSQSSEESPGGTVLMDTPSTQDVPASPTASLVTEGTEGRGCWDVDPGLQGVVTDLAVSDAGEKVEYRSFSGSSQSEIIQAIQNLTRLLYSLQAALTIQDSHIEIHKLVLQQRESLAPSHSFRGGPLQDQEKSRYLEKQREELANIHKLQHQFQQEQRRWHRTCDQQQREQEAQESWLQARERECQSQEELLLRHRSELDHQLQEYQQSLERLREGQRMVERERQKMRVQQGLLGHCKHSRQRSLPAVFSPGSKEVTELNRAESLCHENSFFINEAFGHMSLNTSNKPNPSGVPWDAHPLEGSHFDLARTSESPTELKIDISQPPDVNSELWTTGPGHQRPALQENSKESYKNVADLDSFQSESSSPQDSNQRGPQPQTLTTEAKLSLPMAAGHGGDAGDGAEENILYL
uniprot
proteins
function
FUNCTION: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis. {ECO:0000269|PubMed:11058585, ECO:0000269|PubMed:11435431, ECO:0000269|PubMed:12496377, ECO:0000269|PubMed:12702722, ECO:0000269|PubMed:14499478, ECO:0000269|PubMed:15378065, ECO:0000269|PubMed:16236762, ECO:0000269|PubMed:17993462, ECO:0000269|PubMed:18195107, ECO:0000269|PubMed:9199174}.
uniprot
proteins
mass_dalton
190489
uniprot
proteins
mutagenesis
MUTAGEN 1003; /note="Y->A: Loss of function."; /evidence="ECO:0000269|PubMed:11058585"; MUTAGEN 1375; /note="N->A: Alters interaction with YWHAH."; /evidence="ECO:0000269|PubMed:11533041"; MUTAGEN 1376; /note="L->A: Alters interaction with YWHAH."; /evidence="ECO:0000269|PubMed:11533041"; MUTAGEN 1563; /note="F->A: Alters interaction with MAPK8IP1."; /evidence="ECO:0000269|PubMed:10574993"; MUTAGEN 1565; /note="N->A: Alters interaction with MAPK8IP1."; /evidence="ECO:0000269|PubMed:10574993"; MUTAGEN 1568; /note="F->A: Alters interaction with MAPK8IP1."; /evidence="ECO:0000269|PubMed:10574993
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine upon stimulation of cells by laminin. {ECO:0000269|PubMed:12702722}.
uniprot
proteins
pubmed
10574993
uniprot
proteins
pubmed
11058585
uniprot
proteins
pubmed
11435431
uniprot
proteins
pubmed
11533041
uniprot
proteins
pubmed
12496377
uniprot
proteins
pubmed
12702722
uniprot
proteins
pubmed
14499478
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15378065
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16236762
uniprot
proteins
pubmed
17993462
uniprot
proteins
pubmed
18195107
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9199174
uniprot
proteins
sequence_length
1700
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Colocalizes with the microtubule radial and cortical systems.
uniprot
proteins