Crk
entrez
12928
canonical
uniprot
Q64010
canonical
ensembl
ENSMUSG00000017776
resolver
ensp
ENSMUSP00000017920
resolver
ensp
ENSMUSP00000090803
resolver
ensp
ENSMUSP00000104063
resolver
ensp
ENSMUSP00000104064
resolver
ensp
ENSMUSP00000116527
resolver
enst
ENSMUST00000093115
resolver
enst
ENSMUST00000108425
resolver
enst
ENSMUST00000108426
resolver
genesymbol
Crk
resolver
genesymbol_syn
Crko
resolver
uniprot
F6RS59
resolver
uniprot
F6RS69
resolver
uniprot
F7CGB4
resolver
uniprot
Q3TQV3
resolver
uniprot
Q3TTI0
resolver
uniprot
Q5ND50
resolver
uniprot
Q5ND51
resolver
uniprot
Q8JZR2
resolver
uniprot_entry
CRK_MOUSE
resolver
uniprot_entry
F6RS59_MOUSE
resolver
uniprot_entry
F6RS69_MOUSE
resolver
uniprot_entry
F7CGB4_MOUSE
resolver
uniprot_entry
Q3TQV3_MOUSE
resolver
uniprot_entry
Q5ND50_MOUSE
resolver
uniprot_entry
Q5ND51_MOUSE
resolver
uniprot_entry
Q8JZR2_MOUSE
resolver
uniprot_sec
Q3TTI0
resolver
amino_acid_sequence
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVARSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS
uniprot
proteins
function
FUNCTION: Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000250|UniProtKB:P46108}.; FUNCTION: Isoform CRK-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (By similarity). May regulate the EFNA5-EPHA3 signaling (PubMed:11870224). {ECO:0000250|UniProtKB:P46108, ECO:0000269|PubMed:11870224}.
uniprot
proteins
mass_dalton
33815
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway (PubMed:12878163, PubMed:8194526). Isoform Crk-II: Phosphorylated by KIT (By similarity). {ECO:0000250|UniProtKB:P46108, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:8194526}.; PTM: Proline isomerization at Pro-237 by PPIA acts as a switch between two conformations: an autoinhibitory conformation in the cis form, where the tandem SH3 domains interact intramolecularly, and an activated conformation in the trans form. {ECO:0000250}.
uniprot
proteins
protein_family
CRK family
uniprot
proteins
pubmed
10854253
uniprot
proteins
pubmed
11870224
uniprot
proteins
pubmed
12842890
uniprot
proteins
pubmed
12878163
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7735837
uniprot
proteins
pubmed
8183562
uniprot
proteins
pubmed
8194526
uniprot
proteins
pubmed
9395447
uniprot
proteins
pubmed
9722576
uniprot
proteins
pubmed
9819391
uniprot
proteins
pubmed
9851931
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocated to the plasma membrane upon cell adhesion. {ECO:0000250}.
uniprot
proteins