TRIM62
entrez
55223
canonical
uniprot
Q9BVG3
canonical
ensembl
ENSG00000116525
resolver
ensp
ENSP00000291416
resolver
ensp
ENSP00000441173
resolver
genesymbol
TRIM62
resolver
hgnc
HGNC:25574
resolver
uniprot
B3KVH5
resolver
uniprot
B4DTE4
resolver
uniprot
D3DPR1
resolver
uniprot
Q9NVG0
resolver
uniprot_entry
TRI62_HUMAN
resolver
uniprot_sec
B3KVH5
resolver
uniprot_sec
B4DTE4
resolver
uniprot_sec
D3DPR1
resolver
uniprot_sec
Q9NVG0
resolver
amino_acid_sequence
MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQAHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (PubMed:26488816). E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 (PubMed:23402750). {ECO:0000269|PubMed:23402750, ECO:0000269|PubMed:26488816}.
uniprot
proteins
mass_dalton
54268
uniprot
proteins
mutagenesis
MUTAGEN 11..14; /note="CSIC->ASIA: Abolished E3 ubiquitin ligase activity."; /evidence="ECO:0000269|PubMed:26488816
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:23402750, ECO:0000269|PubMed:26488816}.
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated, autoubiquitinated in the presence of UBE2D2. {ECO:0000269|PubMed:23402750}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
23402750
uniprot
proteins
pubmed
26488816
uniprot
proteins
sequence_length
475
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23402750, ECO:0000269|PubMed:26488816}.
uniprot
proteins