Gpbar1
entrez
227289
canonical
uniprot
Q80SS6
canonical
ensembl
ENSMUSG00000064272
resolver
ensp
ENSMUSP00000077135
resolver
ensp
ENSMUSP00000313967
resolver
enst
ENSMUST00000077985
resolver
genesymbol
Gpbar1
resolver
genesymbol_syn
Tgr5
resolver
uniprot
Q14AA9
resolver
uniprot_entry
GPBAR_MOUSE
resolver
uniprot_entry
Q14AA9_MOUSE
resolver
amino_acid_sequence
MMTPNSTELSAIPMGVLGLSLALASLIVIANLLLALGIALDRHLRSPPAGCFFLSLLLAGLLTGLALPMLPGLWSRNHQGYWSCLLLHLTPNFCFLSLLANLLLVHGERYMAVLQPLRPHGSVRLALFLTWVSSLFFASLPALGWNHWSPDANCSSQAVFPAPYLYLEVYGLLLPAVGATALLSVRVLATAHRQLCEIRRLERAVCRDVPSTLARALTWRQARAQAGATLLFLLCWGPYVATLLLSVLAYERRPPLGPGTLLSLISLGSTSAAAVPVAMGLGDQRYTAPWRTAAQRCLRVLRGRAKRDNPGPSTAYHTSSQCSIDLDLN
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for bile acid (PubMed:15721318, PubMed:16400329). Bile acid-binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:16400329). GPBAR1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:16400329). Activated by bile acids, such as lithocholate, deoxycholate, chenodeoxycholate and cholate, in descending order (By similarity). Apart from their role in lipid dietary absorption and cholesterol catabolism, bile acids act as an important signaling molecule, involved in processes, such as energy expenditure or tissue inflammation (By similarity). GPBAR1-mediated signaling promotes energy expenditure and adiposity reduction in brown adipose tissue by activating adenylate cyclase, leading to DIO2 activation (PubMed:16400329). Involved in bile acid promoted GLP-1 secretion (PubMed:15721318). {ECO:0000250|UniProtKB:Q8TDU6, ECO:0000269|PubMed:15721318, ECO:0000269|PubMed:16400329}.
uniprot
proteins
mass_dalton
35650
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12419312
uniprot
proteins
pubmed
12524422
uniprot
proteins
pubmed
15721318
uniprot
proteins
pubmed
16400329
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8TDU6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TDU6}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..40; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q8TDU6"; TRANSMEM 50..71; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q8TDU6"; TRANSMEM 85..107; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q8TDU6"; TRANSMEM 123..143; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q8TDU6"; TRANSMEM 160..185; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q8TDU6"; TRANSMEM 225..248; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q8TDU6"; TRANSMEM 261..282; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q8TDU6
uniprot
proteins