Mllt3
entrez
70122
canonical
uniprot
A2AM29
canonical
ensembl
ENSMUSG00000028496
resolver
ensp
ENSMUSP00000077232
resolver
ensp
ENSMUSP00000128366
resolver
ensp
ENSMUSP00000129523
resolver
enst
ENSMUST00000078090
resolver
enst
ENSMUST00000126353
resolver
enst
ENSMUST00000149357
resolver
genesymbol
Mllt3
resolver
genesymbol_syn
Af9
resolver
uniprot
F6ZRJ5
resolver
uniprot
F7BAY9
resolver
uniprot
Q3UIA3
resolver
uniprot
Q8VDR6
resolver
uniprot
Q99MK4
resolver
uniprot
Q9D2P1
resolver
uniprot_entry
AF9_MOUSE
resolver
uniprot_entry
F6ZRJ5_MOUSE
resolver
uniprot_entry
F7BAY9_MOUSE
resolver
uniprot_entry
Q3UIA3_MOUSE
resolver
uniprot_entry
Q9D2P1_MOUSE
resolver
uniprot_sec
Q8VDR6
resolver
uniprot_sec
Q99MK4
resolver
amino_acid_sequence
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPKKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKDSSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKADSNLLTVTSGQQDKKAPSKRPPASDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSMLPPFDDIVDPNDSDVEENMSSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEAEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS
uniprot
proteins
function
FUNCTION: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (By similarity). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (By similarity). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (By similarity). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (By similarity). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (By similarity). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (By similarity). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (By similarity). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than conferring, HSC stemness (By similarity). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (By similarity). Required for DOT1L-mediated H3K79 hypermethylation at the SCNN1A promoter, resulting in transcriptional repression (PubMed:16636056). May play a role in leukemogenic gene transcription (By similarity). {ECO:0000250|UniProtKB:P42568, ECO:0000269|PubMed:16636056}.
uniprot
proteins
mass_dalton
63375
uniprot
proteins
pubmed
11439343
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16636056
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
569
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00376, ECO:0000269|PubMed:11439343}. Chromosome {ECO:0000250|UniProtKB:P42568}. Note=Colocalizes with acylated histone H3. Colocalizes with histone H3 crotonylated at 'Lys-18' (H3K18cr). {ECO:0000250|UniProtKB:P42568}.
uniprot
proteins