Chrna10
entrez
64574
canonical
uniprot
Q9JLB5
canonical
ensembl
ENSRNOG00000020293
resolver
ensembl
ENSRNOG00055029243
resolver
ensembl
ENSRNOG00060003393
resolver
ensembl
ENSRNOG00065023352
resolver
ensp
ENSRNOP00000027506
resolver
ensp
ENSRNOP00055041751
resolver
ensp
ENSRNOP00060004087
resolver
ensp
ENSRNOP00065032438
resolver
enst
ENSRNOT00000027507
resolver
enst
ENSRNOT00055050674
resolver
enst
ENSRNOT00060005586
resolver
enst
ENSRNOT00065039893
resolver
genesymbol
Chrna10
resolver
uniprot_entry
ACH10_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by a myriad of ligands such as acetylcholine (PubMed:12117536). AChR activity is inhibited by the antagonist alpha-conotoxins RgIA and GeXXA, small disulfide-constrained peptides from cone snails (PubMed:25740413). {ECO:0000269|PubMed:12117536, ECO:0000269|PubMed:25740413}.
uniprot
proteins
amino_acid_sequence
MGTRSHYLDLGFLLLLFLPAECLGAEGRLAHKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLHWDPKAYGDLDAIRIPSRLVWRPDIVLYNKADTQPPASASTNVVVRHDGAVRWDAPAITRSSCRVDVSAFPFDAQRCGLTFGSWTHGGHQLDVRPRGTSASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLILAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPNAHPVPAWARVLLLGHLAKGLCVRERGEPCGQSKPLESAPSLQPPPASPAGPCHEPRCLCHQEALLHHIASIASTFRSHRAAQRRHEDWKRLARVMDRFFLGIFFCMALVMSLIVLVQAL
uniprot
proteins
function
FUNCTION: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:11248107, PubMed:12117536, PubMed:14742688, PubMed:16306403). Forms heteropentamers with CHRNA9. Expressed in the inner ear, in sympathetic neurons and in other non-neuronal cells, such as skin keratinocytes and lymphocytes (PubMed:14742688, PubMed:16306403). nAChR formed by CHRNA9:CHRNA10 mediate central nervous system control of auditory and vestibular sensory processing. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11248107, PubMed:12117536). In the ear, mediates synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma (PubMed:11248107). May also regulate keratinocyte adhesion (By similarity). {ECO:0000250|UniProtKB:Q9GZZ6, ECO:0000269|PubMed:11248107, ECO:0000269|PubMed:12117536, ECO:0000269|PubMed:14742688, ECO:0000269|PubMed:16306403}.
uniprot
proteins
mass_dalton
49820
uniprot
proteins
mutagenesis
MUTAGEN 221; /note="E->Q: CHRNA9-CHRNA10 receptor is 25-fold less potently inhibited by the alpha-conotoxin RgIA."; /evidence="ECO:0000269|PubMed:25740413"; MUTAGEN 224; /note="P->Q: CHRNA9-CHRNA10 receptor is 300-fold less potently inhibited by the alpha-conotoxin RgIA."; /evidence="ECO:0000269|PubMed:25740413
uniprot
proteins
protein_family
Acetylcholine receptor (TC 1.A.9.1) subfamily
uniprot
proteins
protein_family
Alpha-10/CHRNA10 sub-subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
11248107
uniprot
proteins
pubmed
12117536
uniprot
proteins
pubmed
12401316
uniprot
proteins
pubmed
14742688
uniprot
proteins
pubmed
15356192
uniprot
proteins
pubmed
16306403
uniprot
proteins
pubmed
25740413
uniprot
proteins
pubmed
26395518
uniprot
proteins
pubmed
27559150
uniprot
proteins
sequence_length
447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:11248107, ECO:0000269|PubMed:12117536}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 268..288; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 302..322; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 426..446; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins