TMCO3
entrez
55002
canonical
uniprot
Q6UWJ1
canonical
ensembl
ENSG00000150403
resolver
ensp
ENSP00000389399
resolver
ensp
ENSP00000484053
resolver
ensp
ENSP00000579220
resolver
ensp
ENSP00000579234
resolver
ensp
ENSP00000645681
resolver
ensp
ENSP00000645683
resolver
ensp
ENSP00000720297
resolver
ensp
ENSP00000720302
resolver
ensp
ENSP00000720317
resolver
ensp
ENSP00000720321
resolver
ensp
ENSP00000720333
resolver
ensp
ENSP00000786347
resolver
ensp
ENSP00000792173
resolver
ensp
ENSP00000792181
resolver
ensp
ENSP00000792182
resolver
genesymbol
SLC9D1
resolver
genesymbol
TMCO3
resolver
genesymbol_syn
C13orf11
resolver
genesymbol_syn
TMCO3
resolver
hgnc
HGNC:20329
resolver
uniprot
A0A024RE09
resolver
uniprot
Q5JSB1
resolver
uniprot
Q6NUN1
resolver
uniprot
Q8NG29
resolver
uniprot
Q8TCI6
resolver
uniprot
Q96EA6
resolver
uniprot
Q9NWT2
resolver
uniprot_entry
A0A024RE09_HUMAN
resolver
uniprot_entry
SL9D1_HUMAN
resolver
uniprot_sec
Q5JSB1
resolver
uniprot_sec
Q6NUN1
resolver
uniprot_sec
Q8NG29
resolver
uniprot_sec
Q8TCI6
resolver
uniprot_sec
Q96EA6
resolver
uniprot_sec
Q9NWT2
resolver
amino_acid_sequence
MKVLGRSFFWVLFPVLPWAVQAVEHEEVAQRVIKLHRGRGVAAMQSRQWVRDSCRKLSGLLRQKNAVLNKLKTAIGAVEKDVGLSDEEKLFQVHTFEIFQKELNESENSVFQAVYGLQRALQGDYKDVVNMKESSRQRLEALREAAIKEETEYMELLAAEKHQVEALKNMQHQNQSLSMLDEILEDVRKAADRLEEEIEEHAFDDNKSVKGVNFEAVLRVEEEEANSKQNITKREVEDDLGLSMLIDSQNNQYILTKPRDSTIPRADHHFIKDIVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKVWKISLQGPCYMTLLMIAFGLLWGHLLRIKPTQSVFISTCLSLSSTPLVSRFLMGSARGDKEGDIDYSTVLLGMLVTQDVQLGLFMAVMPTLIQAGASASSSIVVEVLRILVLIGQILFSLAAVFLLCLVIKKYLIGPYYRKLHMESKGNKEILILGISAFIFLMLTVTELLDVSMELGCFLAGALVSSQGPVVTEEIATSIEPIRDFLAIVFFASIGLHVFPTFVAYELTVLVFLTLSVVVMKFLLAALVLSLILPRSSQYIKWIVSAGLAQVSEFSFVLGSRARRAGVISREVYLLILSVTTLSLLLAPVLWRAAITRCVPRPERRSSL
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in this gene seem to be linked to short stature and cornea guttata and anterior polar cataract. {ECO:0000269|PubMed:27484837, ECO:0000269|PubMed:37554015}.
uniprot
proteins
function
FUNCTION: Probable Na(+):H(+) or K(+):H(+) antiporter (Probable). Upon IGF1-dependent phosphorylation, facilitates the membrane translocation and activation of AKT1 (PubMed:40285646). {ECO:0000269|PubMed:40285646, ECO:0000305|PubMed:37554015, ECO:0000305|PubMed:40285646}.
uniprot
proteins
mass_dalton
75598
uniprot
proteins
mutagenesis
MUTAGEN 85; /note="S->A: Not phosphorylated. Unable to locate at the membrane and activate AKT1."; /evidence="ECO:0000269|PubMed:40285646
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-85 induced by IGF1 facilitates the membrane translocation and activation of AKT1. {ECO:0000269|PubMed:40285646}.
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
27484837
uniprot
proteins
pubmed
37554015
uniprot
proteins
pubmed
40285646
uniprot
proteins
sequence_length
677
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:37554015}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:40285646}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 286..306; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 317..337; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 350..370; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 416..436; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 456..476; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 498..518; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 554..574; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 578..598; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 608..628; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 640..660; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins