GSAP
entrez
54103
canonical
uniprot
A4D1B5
canonical
ensembl
ENSG00000186088
resolver
ensp
ENSP00000257626
resolver
ensp
ENSP00000644394
resolver
ensp
ENSP00000644395
resolver
ensp
ENSP00000644396
resolver
ensp
ENSP00000644398
resolver
ensp
ENSP00000686768
resolver
ensp
ENSP00000686769
resolver
ensp
ENSP00000686771
resolver
ensp
ENSP00000686773
resolver
ensp
ENSP00000778323
resolver
genesymbol
GSAP
resolver
genesymbol_syn
PION
resolver
hgnc
HGNC:28042
resolver
uniprot
A4D1B6
resolver
uniprot
Q3MJC0
resolver
uniprot
Q8ND73
resolver
uniprot
Q9UMH3
resolver
uniprot
Q9Y4L9
resolver
uniprot_entry
GSAP_HUMAN
resolver
uniprot_sec
A4D1B6
resolver
uniprot_sec
Q3MJC0
resolver
uniprot_sec
Q8ND73
resolver
uniprot_sec
Q9UMH3
resolver
uniprot_sec
Q9Y4L9
resolver
amino_acid_sequence
MALRLVADFDLGKDVLPWLRAQRAVSEASGAGSGGADVLENDYESLHVLNVERNGNIIYTYKDDKGNVVFGLYDCQTRQNELLYTFEKDLQVFSCSVNSERTLLAASLVQSTKEGKRNELQPGSKCLTLLVEIHPVNNVKVLKAVDSYIWVQFLYPHIESHPLPENHLLLISEEKYIEQFRIHVAQEDGNRVVIKNSGHLPRDRIAEDFVWAQWDMSEQRLYYIDLKKSRSILKCIQFYADESYNLMFEVPLDISLSNSGFKLVNFGCDYHQYRDKFSKHLTLCVFTNHTGSLCVCYSPKCASWGQITYSVFYIHKGHSKTFTTSLENVGSHMTKGITFLNLDYYVAVYLPGHFFHLLNVQHPDLICHNLFLTGNNEMIDMLPHCPLQSLSGSLVLDCCSGKLYRALLSQSSLLQLLQNTCLDCEKMAALHCALYCGQGAQFLEAQIIQWISENVSACHSFDLIQEFIIASSYWSVYSETSNMDKLLPHSSVLTWNTEIPGITLVTEDIALPLMKVLSFKGYWEKLNSNLEYVKYAKPHFHYNNSVVRREWHNLISEEKTGKRRSAAYVRNILDNAVKVISNLEARNLGPRLTPLLQEEDSHQRLLMGLMVSELKDHFLRHLQGVEKKKIEQMVLDYISKLLDLICHIVETNWRKHNLHSWVLHFNSRGSAAEFAVFHIMTRILEATNSLFLPLPPGFHTLHTILGVQCLPLHNLLHCIDSGVLLLTETAVIRLMKDLDNTEKNEKLKFSIIVRLPPLIGQKICRLWDHPMSSNIISRNHVTRLLQNYKKQPRNSMINKSSFSVEFLPLNYFIEILTDIESSNQALYPFEGHDNVDAEFVEEAALKHTAMLLGL
uniprot
proteins
function
FUNCTION: Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. {ECO:0000269|PubMed:20811458}.
uniprot
proteins
mass_dalton
97802
uniprot
proteins
post_translational_modification
PTM: The protein is first synthesized as a holoprotein form of 98 kDa and rapidly processed into the gamma-secretase-activating protein 16 kDa C-terminal form, which constitutes the predominant form. {ECO:0000269|PubMed:20811458}.
uniprot
proteins
protein_family
GSAP family
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20811458
uniprot
proteins
sequence_length
854
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:20811458}.
uniprot
proteins