Emc8
entrez
361425
canonical
uniprot
Q5FVL2
canonical
ensembl
ENSRNOG00000017654
resolver
ensembl
ENSRNOG00055021979
resolver
ensembl
ENSRNOG00060017924
resolver
ensembl
ENSRNOG00065006759
resolver
ensp
ENSRNOP00000023855
resolver
ensp
ENSRNOP00055030770
resolver
ensp
ENSRNOP00060024906
resolver
ensp
ENSRNOP00065007732
resolver
enst
ENSRNOT00000023855
resolver
enst
ENSRNOT00055037727
resolver
enst
ENSRNOT00060030760
resolver
enst
ENSRNOT00065010509
resolver
genesymbol
Emc8
resolver
genesymbol_syn
Cox4nb
resolver
uniprot_entry
EMC8_RAT
resolver
amino_acid_sequence
MPGVKLTTQAYCKMVLHGAKYPHCAVNGLLVAERQRPRKEHPPGAGNHTLFVDCIPLFHGTLALTPMLEVALTLIDSWCKDNSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFSDAALIMVDNAKFTMDCAAPTIHVYEQHENRWRCRDPHHDYCEDWPEAQRISASLLDSRSYETLVDFDNHLDDIRSDWTNPEINKAVLHLC
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. {ECO:0000250|UniProtKB:O43402}.
uniprot
proteins
mass_dalton
23406
uniprot
proteins
protein_family
EMC8/EMC9 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
207
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43402}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43402}; Cytoplasmic side {ECO:0000250|UniProtKB:O43402}.
uniprot
proteins