NUF2
entrez
83540
canonical
uniprot
Q9BZD4
canonical
ensembl
ENSG00000143228
resolver
ensp
ENSP00000271452
resolver
ensp
ENSP00000356875
resolver
ensp
ENSP00000581897
resolver
ensp
ENSP00000581898
resolver
enst
ENST00000271452
resolver
enst
ENST00000367900
resolver
enst
ENST00000911838
resolver
enst
ENST00000911839
resolver
genesymbol
NUF2
resolver
genesymbol_syn
CDCA1
resolver
genesymbol_syn
NUF2R
resolver
hgnc
HGNC:14621
resolver
uniprot
Q8WU69
resolver
uniprot
Q96HJ4
resolver
uniprot
Q96Q78
resolver
uniprot_entry
NUF2_HUMAN
resolver
uniprot_sec
Q8WU69
resolver
uniprot_sec
Q96HJ4
resolver
uniprot_sec
Q96Q78
resolver
amino_acid_sequence
METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIRLEHFYMMPVNSEVMYPHLMEGFLPFSNLVTHLDSFLPICRVNDFETADILCPKAKRTSRFLSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMST
uniprot
proteins
function
FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:12438418, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23085020}.
uniprot
proteins
mass_dalton
54304
uniprot
proteins
post_translational_modification
PTM: Can be phosphorylated by AURKA and AURKB. {ECO:0000269|PubMed:14602875}.
uniprot
proteins
protein_family
NUF2 family
uniprot
proteins
pubmed
11266451
uniprot
proteins
pubmed
11685532
uniprot
proteins
pubmed
12438418
uniprot
proteins
pubmed
14602875
uniprot
proteins
pubmed
14654001
uniprot
proteins
pubmed
14699129
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15062103
uniprot
proteins
pubmed
15235793
uniprot
proteins
pubmed
15239953
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15548592
uniprot
proteins
pubmed
15961401
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17535814
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23085020
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore localization.
uniprot
proteins