Syt10
entrez
54526
canonical
uniprot
Q9R0N4
canonical
ensembl
ENSMUSG00000063260
resolver
ensp
ENSMUSP00000029441
resolver
ensp
ENSMUSP00000309426
resolver
ensp
ENSMUSP00000309429
resolver
enst
ENSMUST00000029441
resolver
genesymbol
Syt10
resolver
uniprot
Q059J3
resolver
uniprot_entry
Q059J3_MOUSE
resolver
uniprot_entry
SYT10_MOUSE
resolver
amino_acid_sequence
MSFRKEDGVSSLCQKALHIITELCFAGQVEWDKCSGIFPADRSGQGGGGTDISVSLLAVVVSFCGLALLVVSLFVFWKLCWPCWKSKLVAPNLSVLPQSISSAPTEVFETEEKKEVEENEKPAPKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQRQTTEPTSSSRHNSFRRHLPRQMNVSSVDFSVGTEPILQRGETRTSIGRIKPELYKQKSVDSEGNRKDDVKTCGKLNFALQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKIYLLPDRKKKFQTRVHRKTLNPLFDELFQFPVVYDQLSNRKLHFSIYDFDRFSRHDMIGEVILDNLFEVSDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLCIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLAYHRKPITHWHPLLELPGRATSFDSQGSCSSPRPPSTP
uniprot
proteins
function
FUNCTION: Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb (PubMed:21496647). Exocytosis of IGF1 is required for sensory perception of smell (PubMed:21496647). Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (PubMed:21496647). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). {ECO:0000250|UniProtKB:O08625, ECO:0000269|PubMed:21496647}.
uniprot
proteins
mass_dalton
59019
uniprot
proteins
mutagenesis
MUTAGEN 268; /note="D->A: Loss of function; when associated with A-320; A-322; A-400; A-454 and A-456."; /evidence="ECO:0000269|PubMed:21496647"; MUTAGEN 320; /note="D->A: Loss of function; when associated with A-268; A-322; A-400; A-454 and A-456."; /evidence="ECO:0000269|PubMed:21496647"; MUTAGEN 322; /note="D->A: Loss of function; when associated with A-268; A-320; A-400; A-454 and A-456."; /evidence="ECO:0000269|PubMed:21496647"; MUTAGEN 400; /note="D->A: Loss of function; when associated with A-268; A-320; A-322; A-454 and A-456."; /evidence="ECO:0000269|PubMed:21496647"; MUTAGEN 454; /note="D->A: Loss of function; when associated with A-268; A-320; A-322; A-400 and A-456."; /evidence="ECO:0000269|PubMed:21496647"; MUTAGEN 456; /note="D->A: Loss of function; when associated with A-268; A-320; A-322; A-400 and A-454."; /evidence="ECO:0000269|PubMed:21496647
uniprot
proteins
protein_family
Synaptotagmin family
uniprot
proteins
pubmed
10531343
uniprot
proteins
pubmed
10531344
uniprot
proteins
pubmed
10871604
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21496647
uniprot
proteins
pubmed
23345244
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:21496647, ECO:0000269|PubMed:23345244}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to neuronal vesicles containing IGF1 that are not enriched at synapses (PubMed:21496647, PubMed:23345244). Does not colocalize with synaptic vesicles or with the Golgi apparatus (PubMed:21496647, PubMed:23345244). {ECO:0000269|PubMed:21496647, ECO:0000269|PubMed:23345244}.
uniprot
proteins
transmembrane_region
TRANSMEM 56..76; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins