ACSM1
entrez
116285
canonical
uniprot
Q08AH1
canonical
ensembl
ENSG00000166743
resolver
ensp
ENSP00000301956
resolver
ensp
ENSP00000428047
resolver
ensp
ENSP00000558220
resolver
genesymbol
ACSM1
resolver
genesymbol_syn
BUCS1
resolver
genesymbol_syn
LAE
resolver
genesymbol_syn
MACS1
resolver
hgnc
HGNC:18049
resolver
uniprot
B2RAP4
resolver
uniprot
Q08AH2
resolver
uniprot
Q96A20
resolver
uniprot_entry
ACSM1_HUMAN
resolver
uniprot_entry
B2RAP4_HUMAN
resolver
uniprot_sec
Q08AH2
resolver
uniprot_sec
Q96A20
resolver
activity_regulation
ACTIVITY REGULATION: Activated by monovalent cations, such as potassium, rubidium or ammonium. {ECO:0000269|PubMed:10434065}.
uniprot
proteins
amino_acid_sequence
MQWLMRFRTLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLDYWAQKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCPSLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTKVIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTGLLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNIGIRIKPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKKETGQM
uniprot
proteins
ec_number
6.2.1.2
uniprot
proteins
ec_number
6.2.1.25
uniprot
proteins
function
FUNCTION: Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10434065). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10434065). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (By similarity). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (By similarity). {ECO:0000250|UniProtKB:Q9BEA2, ECO:0000269|PubMed:10434065}.
uniprot
proteins
mass_dalton
65273
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
10434065
uniprot
proteins
pubmed
11470804
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27351777
uniprot
proteins
sequence_length
577
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q91VA0}. Mitochondrion {ECO:0000250|UniProtKB:Q91VA0}.
uniprot
proteins