Gabbr2
entrez
242425
canonical
uniprot
Q80T41
canonical
ensembl
ENSMUSG00000039809
resolver
ensp
ENSMUSP00000103378
resolver
enst
ENSMUST00000107749
resolver
genesymbol
Gabbr2
resolver
genesymbol_syn
Gm425
resolver
genesymbol_syn
Gpr51
resolver
uniprot
A2AL05
resolver
uniprot_entry
GABR2_MOUSE
resolver
uniprot_sec
A2AL05
resolver
amino_acid_sequence
MASPPSSGQPRPPPPPPPPARLLLPLLLSLLLSLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHFRWRRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGWYEPAWWEQVHVEANSSRCLRRSLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNSKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILSLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL
uniprot
proteins
function
FUNCTION: Component of a heterodimeric G protein-coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:10075644). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (By similarity). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (By similarity). Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (PubMed:20400944). {ECO:0000250|UniProtKB:O75899, ECO:0000269|PubMed:10075644, ECO:0000269|PubMed:20400944}.
uniprot
proteins
mass_dalton
105666
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
protein_family
GABA-B receptor subfamily
uniprot
proteins
pubmed
10075644
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20400944
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
940
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20400944}; Multi-pass membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000269|PubMed:20400944}; Multi-pass membrane protein {ECO:0000250}. Note=Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 483..503; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 522..542; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 551..571; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 597..617; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 654..674; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 691..711; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 720..740; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins