Frat1
entrez
14296
canonical
uniprot
P70339
canonical
ensembl
ENSMUSG00000067199
resolver
ensp
ENSMUSP00000147726
resolver
enst
ENSMUST00000087155
resolver
genesymbol
Frat1
resolver
uniprot
B2RU64
resolver
uniprot_entry
B2RU64_MOUSE
resolver
uniprot_entry
FRAT1_MOUSE
resolver
amino_acid_sequence
MPCRREEEEEAGDEAEGEEDDDSFLLLQQSVTLGGSTDVDQLIVQIGETLQLDAAHDRPASPCAAPGPPPPQVLAALPADKTGTPARRLLRPTGSAETGNPAPPGAVRCVLGERGRVRGRSAPYCVAEISPGASALPQQPGLDGPPGTGKLSTPQPLSGPCRRGWLRNAAASRRLQQRRGSQPETRTGDDDDPHRLLQQLVLSGNLIKEAVRRLHSRQLQLHAKLPAHPFLGPLSAPVHEPPSPGSPRAACSDPGAFMGRAQLRTGDDLLVPGS
uniprot
proteins
disease_involvement
DISEASE: Note=Activation contributes to progression of mouse T-cell lymphomas (PubMed:9034327). {ECO:0000269|PubMed:9034327}.
uniprot
proteins
function
FUNCTION: Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis. {ECO:0000269|PubMed:15073180}.
uniprot
proteins
mass_dalton
28875
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:15073180}.
uniprot
proteins
protein_family
GSK-3-binding protein family
uniprot
proteins
pubmed
15073180
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9034327
uniprot
proteins
sequence_length
274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15073180}.
uniprot
proteins