Atp2b2
entrez
11941
canonical
uniprot
Q9R0K7
canonical
ensembl
ENSMUSG00000030302
resolver
ensp
ENSMUSP00000086398
resolver
ensp
ENSMUSP00000098605
resolver
ensp
ENSMUSP00000098606
resolver
ensp
ENSMUSP00000138165
resolver
ensp
ENSMUSP00000145174
resolver
ensp
ENSMUSP00000209436
resolver
ensp
ENSMUSP00000209437
resolver
ensp
ENSMUSP00000209438
resolver
ensp
ENSMUSP00000209442
resolver
ensp
ENSMUSP00000209451
resolver
ensp
ENSMUSP00000209455
resolver
ensp
ENSMUSP00000209458
resolver
ensp
ENSMUSP00000209464
resolver
ensp
ENSMUSP00000209471
resolver
ensp
ENSMUSP00000209475
resolver
ensp
ENSMUSP00000209476
resolver
ensp
ENSMUSP00000209477
resolver
ensp
ENSMUSP00000209483
resolver
ensp
ENSMUSP00000209494
resolver
ensp
ENSMUSP00000326794
resolver
enst
ENSMUST00000089003
resolver
enst
ENSMUST00000101044
resolver
enst
ENSMUST00000101045
resolver
enst
ENSMUST00000152831
resolver
enst
ENSMUST00000205052
resolver
genesymbol
Atp2b2
resolver
genesymbol_syn
Pmca2
resolver
uniprot
A0A0N4SVN1
resolver
uniprot
F8WHB1
resolver
uniprot
O88863
resolver
uniprot
Q3UHH0
resolver
uniprot
Q3UHJ3
resolver
uniprot
S4R1C4
resolver
uniprot_entry
A0A0N4SVN1_MOUSE
resolver
uniprot_entry
AT2B2_MOUSE
resolver
uniprot_entry
F8WHB1_MOUSE
resolver
uniprot_entry
Q3UHH0_MOUSE
resolver
uniprot_entry
Q3UHJ3_MOUSE
resolver
uniprot_entry
S4R1C4_MOUSE
resolver
uniprot_sec
O88863
resolver
activity_regulation
ACTIVITY REGULATION: Up-regulated by calmodulin which increases the affinity of the pump for Ca(2+) ions (By similarity). Regulated by phospholipids such as phosphatidylinositol 4,5-bisphosphate; this interaction is essential for optimal activity (PubMed:40836084). {ECO:0000250|UniProtKB:Q01814, ECO:0000269|PubMed:40836084}.
uniprot
proteins
amino_acid_sequence
MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGESNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQIKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKAKQQDGAAAMEMQPLKSAEGGDADDKKKANMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLTECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINAKTLELLVNAIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFVLDLRQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKMPDESFRMYSKGASEIVLKKCCKILSGAGEARVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLTLIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Atp2b2 are associated with early onset profound hearing loss and severe vestibular dysfunction. {ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:9697703}.
uniprot
proteins
ec_number
7.2.2.10
uniprot
proteins
function
FUNCTION: ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:17234811, PubMed:9668038, PubMed:40836084). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:40836084). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics (PubMed:17409239, PubMed:20083513). At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (PubMed:17409239, PubMed:20083513). Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (By similarity) (PubMed:9668038). Regulates Ca(2+) signaling through dissipation of Ca(2+) transients generated by store-operated channels (By similarity). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (PubMed:15302868). {ECO:0000250|UniProtKB:Q01814, ECO:0000269|PubMed:15302868, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:17409239, ECO:0000269|PubMed:20083513, ECO:0000269|PubMed:40836084, ECO:0000269|PubMed:9668038}.
uniprot
proteins
mass_dalton
132588
uniprot
proteins
mutagenesis
MUTAGEN 344; /note="K->T: Impairs transporter activity; when associated with T-347 and L-351."; /evidence="ECO:0000269|PubMed:40836084"; MUTAGEN 347; /note="K->T: Impairs transporter activity; when associated with T-344 and L-351."; /evidence="ECO:0000269|PubMed:40836084"; MUTAGEN 351; /note="Q->L: Impairs transporter activity; when associated with T-344 and T-347."; /evidence="ECO:0000269|PubMed:40836084"; MUTAGEN 412; /note="E->K: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:40836084"; MUTAGEN 837; /note="Q->A: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:40836084"; MUTAGEN 841; /note="N->D: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:40836084"; MUTAGEN 873; /note="D->K: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:40836084"; MUTAGEN 877; /note="S->F: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:40836084
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIB subfamily
uniprot
proteins
pubmed
11985881
uniprot
proteins
pubmed
12209837
uniprot
proteins
pubmed
15302868
uniprot
proteins
pubmed
17234811
uniprot
proteins
pubmed
17409239
uniprot
proteins
pubmed
20083513
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
40836084
uniprot
proteins
pubmed
9668038
uniprot
proteins
pubmed
9697703
uniprot
proteins
sequence_length
1198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:40836084}; Multi-pass membrane protein {ECO:0000269|PubMed:40836084}. Apical cell membrane {ECO:0000250|UniProtKB:Q01814}; Multi-pass membrane protein {ECO:0000269|PubMed:40836084}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q01814}; Multi-pass membrane protein {ECO:0000269|PubMed:40836084}. Synapse {ECO:0000269|PubMed:12209837}.
uniprot
proteins
transmembrane_region
TRANSMEM 95..115; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:40836084, ECO:0007744|PDB:9GSD, ECO:0007744|PDB:9GSE, ECO:0007744|PDB:9GSF, ECO:0007744|PDB:9GSG, ECO:0007744|PDB:9GSH, ECO:0007744|PDB:9GSI, ECO:0007744|PDB:9GSY, ECO:0007744|PDB:9GTB"; TRANSMEM 153..173; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:40836084, ECO:0007744|PDB:9GSD, ECO:0007744|PDB:9GSE, ECO:0007744|PDB:9GSF, ECO:0007744|PDB:9GSG, ECO:0007744|PDB:9GSH, ECO:0007744|PDB:9GSI, ECO:0007744|PDB:9GSY, ECO:0007744|PDB:9GTB"; TRANSMEM 346..365; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:40836084, ECO:0007744|PDB:9GSD, ECO:0007744|PDB:9GSE, ECO:0007744|PDB:9GSF, ECO:0007744|PDB:9GSG, ECO:0007744|PDB:9GSH, ECO:0007744|PDB:9GSI, ECO:0007744|PDB:9GSY, ECO:0007744|PDB:9GTB"; TRANSMEM 399..416; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:40836084, ECO:0007744|PDB:9GSD, ECO:0007744|PDB:9GSE, ECO:0007744|PDB:9GSF, ECO:0007744|PDB:9GSG, ECO:0007744|PDB:9GSH, ECO:0007744|PDB:9GSI, ECO:0007744|PDB:9GSY, ECO:0007744|PDB:9GTB"; TRANSMEM 831..850; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:40836084, ECO:0007744|PDB:9GSD, ECO:0007744|PDB:9GSE, ECO:0007744|PDB:9GSF, ECO:0007744|PDB:9GSG, ECO:0007744|PDB:9GSH, ECO:0007744|PDB:9GSI, ECO:0007744|PDB:9GSY, ECO:0007744|PDB:9GTB"; TRANSMEM 861..881; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:40836084, ECO:0007744|PDB:9GSD, ECO:0007744|PDB:9GSE, ECO:0007744|PDB:9GSF, ECO:0007744|PDB:9GSG, ECO:0007744|PDB:9GSH, ECO:0007744|PDB:9GSI, ECO:0007744|PDB:9GSY, ECO:0007744|PDB:9GTB"; TRANSMEM 902..924; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:40836084, ECO:0007744|PDB:9GSD, ECO:0007744|PDB:9GSE, ECO:0007744|PDB:9GSF, ECO:0007744|PDB:9GSG, ECO:0007744|PDB:9GSH, ECO:0007744|PDB:9GSI, ECO:0007744|PDB:9GSY, ECO:0007744|PDB:9GTB"; TRANSMEM 943..964; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:40836084, ECO:0007744|PDB:9GSD, ECO:0007744|PDB:9GSE, ECO:0007744|PDB:9GSF, ECO:0007744|PDB:9GSG, ECO:0007744|PDB:9GSH, ECO:0007744|PDB:9GSI, ECO:0007744|PDB:9GSY, ECO:0007744|PDB:9GTB"; TRANSMEM 984..1005; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:40836084, ECO:0007744|PDB:9GSD, ECO:0007744|PDB:9GSE, ECO:0007744|PDB:9GSF, ECO:0007744|PDB:9GSG, ECO:0007744|PDB:9GSH, ECO:0007744|PDB:9GSI, ECO:0007744|PDB:9GSY, ECO:0007744|PDB:9GTB"; TRANSMEM 1016..1037; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:40836084, ECO:0007744|PDB:9GSD, ECO:0007744|PDB:9GSE, ECO:0007744|PDB:9GSF, ECO:0007744|PDB:9GSG, ECO:0007744|PDB:9GSH, ECO:0007744|PDB:9GSI, ECO:0007744|PDB:9GSY, ECO:0007744|PDB:9GTB
uniprot
proteins