Prr7
entrez
498704
canonical
uniprot
P0C6T3
canonical
ensembl
ENSRNOG00055015685
resolver
ensembl
ENSRNOG00060022633
resolver
ensembl
ENSRNOG00065022421
resolver
ensp
ENSRNOP00055021666
resolver
ensp
ENSRNOP00060032456
resolver
ensp
ENSRNOP00065030950
resolver
enst
ENSRNOT00055026733
resolver
enst
ENSRNOT00060039250
resolver
enst
ENSRNOT00065038230
resolver
genesymbol
Prr7
resolver
uniprot_entry
PRR7_RAT
resolver
amino_acid_sequence
MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGSLAGSPPGLAPPPPPHRSRLEAPVHAHSHVHVHPLLHHGPAQPHAHPHPHHHALPHPPPSHLSVPPRPWSYPRQAESDMSKPPCYEEAVLMAEPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPAAPCPALCLQADRSRRVFPSWTDSELSSREPLEHGAWRLPVSIPLFGRTTAV
uniprot
proteins
function
FUNCTION: Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (PubMed:27458189). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (By similarity). Might promote apoptosis in T cells (By similarity). {ECO:0000250|UniProtKB:Q8TB68, ECO:0000269|PubMed:27458189}.
uniprot
proteins
mass_dalton
30377
uniprot
proteins
mutagenesis
MUTAGEN 39..47; /note="KRRQEERLR->AAAQEEALA: Loss of nuclear localization and loss of apoptosis induction."; /evidence="ECO:0000269|PubMed:27458189
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. {ECO:0000250|UniProtKB:Q8TB68}.; PTM: Tyrosine phosphorylated, possibly by SRC. {ECO:0000250|UniProtKB:Q8TB68}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15629447
uniprot
proteins
pubmed
27458189
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8TB68}; Single-pass type III membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000269|PubMed:15629447}; Single-pass type III membrane protein {ECO:0000305}. Postsynaptic density membrane {ECO:0000269|PubMed:15629447, ECO:0000269|PubMed:27458189}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8TB68}. Synapse {ECO:0000269|PubMed:27458189}. Cell projection, dendrite {ECO:0000269|PubMed:27458189}. Nucleus {ECO:0000269|PubMed:27458189}. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD) (PubMed:15629447, PubMed:27458189). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern (PubMed:15629447). Translocates from synapses to nuclei following NMDA receptor activity (PubMed:27458189). {ECO:0000269|PubMed:15629447, ECO:0000269|PubMed:27458189}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins