Plau
entrez
18792
canonical
uniprot
P06869
canonical
ensembl
ENSMUSG00000021822
resolver
ensp
ENSMUSP00000022368
resolver
ensp
ENSMUSP00000244435
resolver
enst
ENSMUST00000022368
resolver
genesymbol
Plau
resolver
uniprot
Q0VBA8
resolver
uniprot_entry
Q0VBA8_MOUSE
resolver
uniprot_entry
UROK_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by SERPINA5 (By similarity). Inhibited by SERPINE1 (By similarity). {ECO:0000250|UniProtKB:P00749}.
uniprot
proteins
amino_acid_sequence
MKVWLASLFLCALVVKNSEGGSVLGAPDESNCGCQNGGVCVSYKYFSRIRRCSCPRKFQGEHCEIDASKTCYHGNGDSYRGKANTDTKGRPCLAWNAPAVLQKPYNAHRPDAISLGLGKHNYCRNPDNQKRPWCYVQIGLRQFVQECMVHDCSLSKKPSSSVDQQGFQCGQKALRPRFKIVGGEFTEVENQPWFAAIYQKNKGGSPPSFKCGGSLISPCWVASAAHCFIQLPKKENYVVYLGQSKESSYNPGEMKFEVEQLILHEYYREDSLAYHNDIALLKIRTSTGQCAQPSRSIQTICLPPRFTDAPFGSDCEITGFGKESESDYLYPKNLKMSVVKLVSHEQCMQPHYYGSEINYKMLCAADPEWKTDSCKGDSGGPLICNIEGRPTLSGIVSWGRGCAEKNKPGVYTRVSHFLDWIQSHIGEEKGLAF
uniprot
proteins
ec_number
3.4.21.73
uniprot
proteins
function
FUNCTION: Serine protease that cleaves the inactive precursor plasminogen at a specific Arg-Val peptide bond, converting it into active plasmin (PubMed:28611361, PubMed:30707839). Secreted as an inactive zymogen, it is recruited and activated at the cell surface through interaction with the urokinase plasminogen activator receptor (uPAR). Cell-surface activation enables localized, plasmin-dependent pericellular proteolysis, regulating extracellular matrix degradation in cell migration and tissue remodeling (By similarity). Also contributes to fibrinolysis and blood clot clearance by promoting plasmin generation (PubMed:8650190). {ECO:0000250|UniProtKB:P00749, ECO:0000269|PubMed:28611361, ECO:0000269|PubMed:30707839, ECO:0000269|PubMed:8650190}.
uniprot
proteins
mass_dalton
48268
uniprot
proteins
post_translational_modification
PTM: Produced as an inactive single-chain protein (pro-uPA or sc-uPA), is processed into the active disulfide-linked two-chain form of PLAU/uPA by a proteolytic event mediated, at least, by TMPRSS4. {ECO:0000250|UniProtKB:P00749}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
20133942
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2831940
uniprot
proteins
pubmed
28611361
uniprot
proteins
pubmed
2985383
uniprot
proteins
pubmed
30707839
uniprot
proteins
pubmed
8650190
uniprot
proteins
sequence_length
433
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P00749}. Note=Secreted as an inactive zymogen, it is activated through specific proteolytic cleavage. {ECO:0000250|UniProtKB:P00749}.
uniprot
proteins