Slc4a11
entrez
269356
canonical
uniprot
A2AJN7
canonical
ensembl
ENSMUSG00000074796
resolver
ensp
ENSMUSP00000096963
resolver
ensp
ENSMUSP00000232822
resolver
enst
ENSMUST00000099362
resolver
genesymbol
Slc4a11
resolver
genesymbol_syn
BTR1
resolver
uniprot
Q0VG86
resolver
uniprot
Q3URQ1
resolver
uniprot_entry
S4A11_MOUSE
resolver
uniprot_sec
Q0VG86
resolver
uniprot_sec
Q3URQ1
resolver
amino_acid_sequence
MSQNEHCQDSGEYFSAGTQGYFKNNMEDNLEVREDSLGDEVFDTVNSSIVSGESIRFFVNVNLEVQPSKSDLEAATGGCVLLHTSRKYLKLKNFEEEVRAHRDLDGFLAQASIILNETATSLDDVLRTMLNRFALDPNHAEPDCDLDLLMAKLFTDAGAPMESKVHLLSDTIQGVTATVRGVQYEQSWLCIICTMKTLQKRHVCISRLVRPQNWGENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDITFRQKLLKTRTEEEFKEALVHQRQLLTMMMPRAAGHSMSSLHTHRHPQPPKCKDFFPFGKGIWMDIMRRFPVYPMDFTDGIIGKSKSVGKYVTTTLFLYFACLLPTIAFGSLNDENTNGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLAIYTQVIRVICDDYNLDFNAFYAWTGLWNSFFLALYAFLNLSLLMNLFKRSTEEIIALFISITFVLDAVKGMVKIFGKYYYGHHYHTKRTSSLVSLLGIGRSPNSSLHTALNASLLASPVEMATTSSPGSTHSGQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVRETLSDCALPIAVLSFSLIGSYGFQEIEMSKFRYNPSESLFEVAQIHSLSFKAIGSAMGLGFLLSLLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYETIVDVKETRLTALGASVLVGLSLLLLPFPLQWIPKPVLYGLFLYIALTSLDGNQLFSRVALLLKEQTSYPPTHYIRRVPQRKIHYFTGLQILQLLLLCAFGMSSLPYMKMVFPLIMIAMIPIRYNLLPRIIEAKYLDVMDAEHRP
uniprot
proteins
function
FUNCTION: Multifunctional transporter with an impact in cell morphology and differentiation (PubMed:20185830). In the presence of borate B(OH)4(-), acts as a voltage-dependent electrogenic Na(+)-coupled B(OH)4(-) cotransporter controlling boron homeostasis (By similarity). At early stages of stem cell differentiation, participates in synergy with ITGA5-ITGB1 and ITGAV-ITGB3 integrins and BMPR1A to promote cell adhesion and contractility that drives differentiation toward osteogenic commitment while inhibiting adipogenesis (PubMed:33247189). In the absence of B(OH)4(-), acts as a Na(+)-coupled OH(-) or H(+) permeable channel with implications in cellular redox balance. Regulates the oxidative stress response in corneal endothelium by enhancing antioxidant defenses and protecting cells from reactive oxygen species. In response to hypo-osmotic challenge, also acts as water permeable channel at the basolateral cell membrane of corneal endothelial cells and facilitates transendothelial fluid reabsorption in the aqueous humor. In the presence of ammonia, acts as an electrogenic NH3/H(+) cotransporter and may play a role in ammonia transport and reabsorption in renal Henle's loop epithelium (By similarity). {ECO:0000250|UniProtKB:Q8NBS3, ECO:0000269|PubMed:20185830, ECO:0000269|PubMed:33247189}.
uniprot
proteins
mass_dalton
96751
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q8NBS3}.
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20185830
uniprot
proteins
pubmed
23813972
uniprot
proteins
pubmed
33247189
uniprot
proteins
sequence_length
862
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8NBS3}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8NBS3}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 344..366; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 380..393; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 399..415; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 429..452; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 461..481; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 543..564; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 578..599; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 628..645; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 671..691; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 722..746; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 753..770; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 775..797; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 803..819; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 824..844; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins