Rab3b
entrez
69908
canonical
uniprot
Q9CZT8
canonical
ensembl
ENSMUSG00000003411
resolver
ensp
ENSMUSP00000003502
resolver
ensp
ENSMUSP00000102261
resolver
enst
ENSMUST00000003502
resolver
enst
ENSMUST00000106650
resolver
genesymbol
Rab3b
resolver
genesymbol_syn
Rab3B
resolver
uniprot
Q0PD62
resolver
uniprot
Q80WV9
resolver
uniprot
Q920F1
resolver
uniprot_entry
Q0PD62_MOUSE
resolver
uniprot_entry
RAB3B_MOUSE
resolver
uniprot_sec
Q80WV9
resolver
uniprot_sec
Q920F1
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation. {ECO:0000250|UniProtKB:P20336}.
uniprot
proteins
amino_acid_sequence
MASVTDGKTGIKDASDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWATQIKTYSWDNAQVILVGNKCDMEEERVVPTEKGRLLAEQLGFDFFEASAKENISVRQAFERLVDAICDKMSDSMDTDPSVLGASKTTRLSDTPPLLQQNCSC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P20337}.
uniprot
proteins
mass_dalton
24757
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitor GDI2. {ECO:0000250|UniProtKB:P20337}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
12578829
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18396146
uniprot
proteins
pubmed
18849981
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29125462
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000269|PubMed:18396146}. Note=Colocalizes with DRC4 in the Golgi apparatus. {ECO:0000269|PubMed:18396146}.
uniprot
proteins