RNF138
entrez
51444
canonical
uniprot
Q8WVD3
canonical
ensembl
ENSG00000134758
resolver
ensp
ENSP00000257190
resolver
ensp
ENSP00000261593
resolver
ensp
ENSP00000528643
resolver
ensp
ENSP00000581747
resolver
genesymbol
RNF138
resolver
genesymbol_syn
NARF
resolver
hgnc
HGNC:17765
resolver
uniprot
A0A140VJT9
resolver
uniprot
B2RE17
resolver
uniprot
Q9H8K2
resolver
uniprot
Q9UF87
resolver
uniprot
Q9UKI6
resolver
uniprot_entry
A0A140VJT9_HUMAN
resolver
uniprot_entry
RN138_HUMAN
resolver
uniprot_sec
B2RE17
resolver
uniprot_sec
Q9H8K2
resolver
uniprot_sec
Q9UF87
resolver
uniprot_sec
Q9UKI6
resolver
amino_acid_sequence
MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLTAMRESGAHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQDEYGVSSIIPNFQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285). {ECO:0000269|PubMed:16714285, ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}.
uniprot
proteins
mass_dalton
28193
uniprot
proteins
mutagenesis
MUTAGEN 18..21; /note="CPVC->APVA: Catalytic inactive mutant that abolishes ability to promote DNA resection and homologous recombination."; /evidence="ECO:0000269|PubMed:26502057"; MUTAGEN 18; /note="C->A: Catalytic inactive mutant that abolishes ability to promote DNA resection and homologous recombination; when associated with A-54."; /evidence="ECO:0000269|PubMed:26502055"; MUTAGEN 54; /note="C->A: Catalytic inactive mutant that abolishes ability to promote DNA resection and homologous recombination; when associated with A-18."; /evidence="ECO:0000269|PubMed:26502055
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:16714285, ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000269|PubMed:16714285}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16714285
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26502055
uniprot
proteins
pubmed
26502057
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}. Note=Recruited at DNA damage sites (PubMed:26502055). Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers (PubMed:26502055, PubMed:26502057). {ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}.
uniprot
proteins