Dzip1
entrez
66573
canonical
uniprot
Q8BMD2
canonical
ensembl
ENSMUSG00000042156
resolver
ensp
ENSMUSP00000004055
resolver
ensp
ENSMUSP00000039689
resolver
ensp
ENSMUSP00000181320
resolver
ensp
ENSMUSP00000181323
resolver
ensp
ENSMUSP00000181324
resolver
ensp
ENSMUSP00000181326
resolver
ensp
ENSMUSP00000181328
resolver
genesymbol
Dzip1
resolver
genesymbol_syn
Kiaa0996
resolver
uniprot
Q4QQM0
resolver
uniprot
Q6ZQ10
resolver
uniprot
Q9CRK5
resolver
uniprot_entry
DZIP1_MOUSE
resolver
uniprot_sec
Q4QQM0
resolver
uniprot_sec
Q6ZQ10
resolver
uniprot_sec
Q9CRK5
resolver
amino_acid_sequence
MPFQKHVYYPLANSPEGPDASAIGAAPMAFVPPSAASGPLPFFQFRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSGVDPVLLKLIRLAQLTIEYLMHSQEFLTSQLNLVEERLRLSLLDYEQSKQLLTKQAGEIKLLKEECKRRKKMLSTQQLMIEAKASYYQCHFCDKAFMNQAFLQSHIQRRHTEDSHLEYNTKAQTDRLQKEIDMLKEQLQLTRSQLESAQHSHAVRFSKDYEMQKSKEEDFLKLFDRWKEEEKEKLLEEMEKVKGMFMREFKELTSKNSALEYQLLEIQKSNIQIKSNIGTLRDVTELREDHLPCPQDFQNMLQLLDSQASKWTDRFQVLNEEHSKEKGQLLSHIEKLRSSMMKDLSADNVFYKRRVEELGQKLQEQNELIISQKQQIREFASKPYSSISELKGTPLTRQTLEPKSAAPTTPMTASATQNLDGASSLTMVHEQVFSSHILEPIEELSSEEEKGRENEQKLNKKTSLRKPSSTSPSPQELRTNLERELGNKLRSFGIGANIQGIPCEILNRSLKAMQVARHDLAKQMPDIQQIRESLEHQLICKMEEKVSLSSDRHHVPSMTTFPPEEVPKATQLPHKSRPLVRQRTVFTDKVSVPKLKKNTKESHFLRRFPSTKTPPFSSEEEPDEEDLLHAYLSPDSLATAATQPPKSSMSHFGKSAVKSDTDWTEGSEMDDSDFSPKLTGTSITIQTDTVETMALPQGSGNKAVPGMNPADTVIKKESLQELKCTDADDEDWDISSLEEEKSLGSKIEQREPPPAKRDPSCTQVQRAWGPVNPREFKEEGLHENEPSTLKSNLVTVTDWSDVLDV
uniprot
proteins
function
FUNCTION: Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body (PubMed:23955340, PubMed:25860027, PubMed:31118289, PubMed:32051257). At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium (PubMed:25860027). Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium (PubMed:27979967). It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN (PubMed:23955340). Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm (PubMed:23955340). It is involved in spermatogenesis through its role in organization of the basal body and assembly of the sperm flagellum (PubMed:32051257). Also indirectly involved in heart development through its function in ciliogenesis (PubMed:31118289). {ECO:0000269|PubMed:23955340, ECO:0000269|PubMed:25860027, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:31118289, ECO:0000269|PubMed:32051257}.
uniprot
proteins
mass_dalton
97263
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="S->R: Changed cilium assembly. Adult animals develop myxomatous mitral valves and functional mitral valve prolapse."; /evidence="ECO:0000269|PubMed:31118289"; MUTAGEN 210; /note="S->A: Loss of phosphorylation by PLK1. Increased interaction with PCM1."; /evidence="ECO:0000269|PubMed:27979967"; MUTAGEN 210; /note="S->D: Loss of interaction with PCM1."; /evidence="ECO:0000269|PubMed:27979967"; MUTAGEN 520; /note="S->A: Loss of phosphorylation by GSK3-beta. Decreased interaction with GDI2."; /evidence="ECO:0000269|PubMed:25860027"; MUTAGEN 520; /note="S->D: Phosphorylation mimicking mutant. Increased interaction with GDI2."; /evidence="ECO:0000269|PubMed:25860027
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-210 by PLK1 before mitosis prevents interaction with PCM1 and localization to centriolar satellites. Thereby, it negatively regulates the localization of the BBSome to centriolar satellites (PubMed:27979967). Undergoes postmitotic phosphorylation at Ser-520 by GSK3B. That phosphorylated form of DZIP1 interacts with GDI2, disrupting its interaction with RAB8A, leading to RAB8A activation and localization to the cilium where it mediates protein transport and participates to cilium biogenesis (PubMed:25860027). {ECO:0000269|PubMed:25860027, ECO:0000269|PubMed:27979967}.
uniprot
proteins
protein_family
DZIP C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15081113
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23955340
uniprot
proteins
pubmed
25860027
uniprot
proteins
pubmed
27979967
uniprot
proteins
pubmed
31118289
uniprot
proteins
pubmed
32051257
uniprot
proteins
sequence_length
852
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23955340, ECO:0000269|PubMed:25860027, ECO:0000269|PubMed:31118289}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:27979967}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:25860027}. Nucleus {ECO:0000269|PubMed:15081113}. Nucleus speckle {ECO:0000269|PubMed:31118289}. Cytoplasm {ECO:0000269|PubMed:15081113}. Note=Localizes to the centriole in cells lacking cilia and to the cilium basal body in ciliated cells (By similarity). At the exit of mitosis, when the primary cilium is reassembled in daughter cells, localizes at the mother centriole that acts as the basal body of the assembling primary cilium and also accumulates at the ciliary base that constitutes a diffusion barrier for ciliary proteins (PubMed:25860027). {ECO:0000250|UniProtKB:Q86YF9, ECO:0000269|PubMed:25860027}.
uniprot
proteins