DDX49
entrez
54555
canonical
uniprot
Q9Y6V7
canonical
ensembl
ENSG00000105671
resolver
ensp
ENSP00000247003
resolver
genesymbol
DDX49
resolver
hgnc
HGNC:18684
resolver
uniprot
E7ENA0
resolver
uniprot
Q53FJ1
resolver
uniprot
Q9BVQ8
resolver
uniprot_entry
DDX49_HUMAN
resolver
uniprot_sec
E7ENA0
resolver
uniprot_sec
Q53FJ1
resolver
uniprot_sec
Q9BVQ8
resolver
amino_acid_sequence
MAGFAELGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTFSIKKIRFLVMDEADRLLEQGCTDFTVDLEAILAAVPARRQTLLFSATLTDTLRELQGLATNQPFFWEAQAPVSTVEQLDQRYLLVPEKVKDAYLVHLIQRFQDEHEDWSIIIFTNTCKTCQILCMMLRKFSFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLVHAIEEQIKKKLEEFSVEEAEVLQILTQVNVVRRECEIKLEAAHFDEKKEINKRKQLILEGKDPDLEAKRKAELAKIKQKNRRFKEKVEETLKRQKAGRAGHKGRPPRTPSGSHSGPVPSQGLV
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including the regulation of mRNA export and the levels of pre-ribosomal RNA. Regulates the stability and synthesis of pre-ribosomal RNA and thereby regulates cell proliferation (PubMed:29618122). Also possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation (PubMed:36298642). {ECO:0000269|PubMed:29618122, ECO:0000269|PubMed:36298642}.
uniprot
proteins
mass_dalton
54226
uniprot
proteins
protein_family
DDX49/DBP8 subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
29618122
uniprot
proteins
pubmed
36298642
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:29618122}.
uniprot
proteins