Bpifa1
entrez
18843
canonical
uniprot
P97361
canonical
ensembl
ENSMUSG00000027483
resolver
ensp
ENSMUSP00000028985
resolver
enst
ENSMUST00000028985
resolver
genesymbol
Bpifa1
resolver
genesymbol_syn
Plunc
resolver
genesymbol_syn
Splunc1
resolver
uniprot
Q7TQJ2
resolver
uniprot_entry
BPIA1_MOUSE
resolver
uniprot_sec
Q7TQJ2
resolver
amino_acid_sequence
MFLVGSLVVLCGLLAHSTAQLAGLPLPLGQGPPLPLNQGPPLPLNQGQLLPLAQGLPLAVSPALPSNPTDLLAGKFTDALSGGLLSGGLLGILENIPLLDVIKSGGGNSNGLVGGLLGKLTSSVPLLNNILDIKITDPQLLELGLVQSPDGHRLYVTIPLGLTLNVNMPVVGSLLQLAVKLNITAEVLAVKDNQGRIHLVLGDCTHSPGSLKISLLNGVTPVQSFLDNLTGILTKVLPELIQGKVCPLVNGILSGLDVTLVHNIAELLIHGLQFVIKV
uniprot
proteins
function
FUNCTION: Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (By similarity). Plays a role in the innate immune responses of the upper airways (PubMed:23499554). Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae (PubMed:23499554). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (By similarity). Plays a role in the airway inflammatory response after exposure to irritants (By similarity). May attract macrophages and neutrophils (By similarity). {ECO:0000250|UniProtKB:Q9NP55, ECO:0000269|PubMed:23499554}.
uniprot
proteins
mass_dalton
28625
uniprot
proteins
protein_family
BPI/LBP/Plunc superfamily
uniprot
proteins
protein_family
Plunc family
uniprot
proteins
pubmed
10224143
uniprot
proteins
pubmed
11396972
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23499554
uniprot
proteins
pubmed
29717993
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23499554}. Note=Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.
uniprot
proteins