Egr1
entrez
24330
canonical
uniprot
P08154
canonical
ensembl
ENSRNOG00000019422
resolver
ensp
ENSRNOP00000026303
resolver
enst
ENSRNOT00000026303
resolver
genesymbol
Egr1
resolver
uniprot
A0A0H2UHR3
resolver
uniprot
Q53YM5
resolver
uniprot_entry
A0A0H2UHR3_RAT
resolver
uniprot_entry
EGR1_RAT
resolver
uniprot_sec
Q53YM5
resolver
amino_acid_sequence
MDNYPKLEEMMLLSNGAPQFLGAAGTPEGSGGNNSSSSSSSSSGGGGGGGSNSGSSAFNPQGEPSEQPYEHLTTESFSDIALNNEKALVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPTSSSSAPSPAASSSSSASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPATKGGFQVPMIPDYLFPQQQGDLSLGTPDQKPFQGLENRTQQPSLTPLSTIKAFATQSGSQDLKALNNTYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASSAASSLSSYPSPVATSYPSPATTSFPSPVPTSYSSPGSSTYPSPAHSGFPSPSVATTYASVPPAFPAQVSTFQSAGVSNSFSTSTGLSDMTATFSPRTIEIC
uniprot
proteins
function
FUNCTION: Transcriptional regulator (PubMed:8413279). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (PubMed:15220929). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). Regulates biosynthesis of glucocorticoid receptor GR/NR3C1 in the hippocampus and thereby may play a role in the behavioral and hypothalamic-pituitary-adrenal responses to stress in offspring (PubMed:15220929). {ECO:0000250|UniProtKB:P08046, ECO:0000250|UniProtKB:P18146, ECO:0000269|PubMed:8413279}.
uniprot
proteins
mass_dalton
53935
uniprot
proteins
mutagenesis
MUTAGEN 265; /note="I->F: Increases transcriptional activity."; /evidence="ECO:0000269|PubMed:8413279
uniprot
proteins
protein_family
EGR C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
15220929
uniprot
proteins
pubmed
1859855
uniprot
proteins
pubmed
2492104
uniprot
proteins
pubmed
3672127
uniprot
proteins
pubmed
8413279
uniprot
proteins
sequence_length
508
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1859855}. Cytoplasm {ECO:0000250|UniProtKB:P18146}.
uniprot
proteins