Olfm2
entrez
313783
canonical
uniprot
Q568Y7
canonical
ensembl
ENSRNOG00000020519
resolver
ensembl
ENSRNOG00055012712
resolver
ensembl
ENSRNOG00060027856
resolver
ensembl
ENSRNOG00065011442
resolver
ensp
ENSRNOP00000027829
resolver
ensp
ENSRNOP00000097675
resolver
enst
ENSRNOT00000108558
resolver
genesymbol
Olfm2
resolver
uniprot
A0A8I6GMM3
resolver
uniprot
A6JNL2
resolver
uniprot_entry
A0A8I6GMM3_RAT
resolver
uniprot_entry
NOE2_RAT
resolver
uniprot_sec
A6JNL2
resolver
amino_acid_sequence
MSVPLLKIGAVLSTMAMVTNWMSQTLPSLVGLNSTVSRAGSSEKITLFQSPEEGWQLYTSAQAPDGKCICTAVIPAQSTCARDGRSRELRQLMEKVQNVSQSMEVLELRTYRDLQYVRSMETLMRSLDARLRTADGSVSAKSFQELKDRMTELLPLSSVLEQYKADTRTIVRLREEVRNLSGNLAAIQEEMGAYGYEDLQQRVMALEARLHACAQKLGCGKLTGVSNPITIRAMGSRFGSWMTDTMAPSADSRVWYMDGYYKGRRVLEFRTLGDFIKGQNFIQHLLPQPWAGTGHVVYNGSLFYNKYQSNVVVKYHFRSRSVLVQRSLPGAGYNNTFPYSWGGFSDMDFMVDESGLWAVYTTNQNAGNIVVSRLDPHTLEVVRSWDTGYPKRSAGEAFMICGVLYVTNSHLAGAKVYFAYFTNTSSYEYTDVPFHNQYSHISMLDYNPRERALYTWNNGHQVLYNVTLFHVISTAGDP
uniprot
proteins
function
FUNCTION: Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and nuclear translocation of OLFM2 where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes. Plays a role in AMPAR complex organization. Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (PubMed:28062493). {ECO:0000250|UniProtKB:O95897, ECO:0000250|UniProtKB:Q8BM13, ECO:0000269|PubMed:28062493}.
uniprot
proteins
mass_dalton
53870
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22632720
uniprot
proteins
pubmed
28062493
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O95897}. Synapse {ECO:0000305|PubMed:22632720}. Membrane {ECO:0000250|UniProtKB:Q8BM13}. Nucleus {ECO:0000250|UniProtKB:O95897}. Cytoplasm {ECO:0000250|UniProtKB:O95897}. Note=Nuclear localization is induced by TGF-beta. {ECO:0000250|UniProtKB:O95897}.
uniprot
proteins