C8g
entrez
69379
canonical
uniprot
Q8VCG4
canonical
ensembl
ENSMUSG00000015083
resolver
ensp
ENSMUSP00000015227
resolver
ensp
ENSMUSP00000041855
resolver
ensp
ENSMUSP00000289547
resolver
enst
ENSMUST00000015227
resolver
enst
ENSMUST00000040042
resolver
genesymbol
C8g
resolver
uniprot
F6YII1
resolver
uniprot
Q9DAC2
resolver
uniprot_entry
CO8G_MOUSE
resolver
uniprot_entry
F6YII1_MOUSE
resolver
uniprot_entry
Q9DAC2_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Membrane attack complex (MAC) assembly is inhibited by CD59, thereby protecting self-cells from damage during complement activation. MAC assembly is also inhibited by clusterin (CLU) chaperones that inhibit polymerization of C9. {ECO:0000250|UniProtKB:P07360}.
uniprot
proteins
amino_acid_sequence
MLSPGAVLFFTLLLTASSLGQRTRKPIGSTSPISTIQAQVNFSAQKFAGTWLLVAVGSSCRFLQEQGHRAEATTLHAAPQGAAMAVSTFRKLDGICWQVRQLFENTGVPGRFLFQVSRARGPVHMVVAETDYQSFAILYLEQGRKLSVKLYVRSLPVNDSVLDVFERRVREANLTEDQILFFPKYGFCETADQLHILNEVPR
uniprot
proteins
function
FUNCTION: Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8G, together with C8A and C8B, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity. {ECO:0000250|UniProtKB:P07360}.
uniprot
proteins
mass_dalton
22508
uniprot
proteins
protein_family
Calycin superfamily
uniprot
proteins
protein_family
Lipocalin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16944957
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
202
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P07360}. Target cell membrane {ECO:0000250|UniProtKB:P07360}. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells. {ECO:0000250|UniProtKB:P07360}.
uniprot
proteins