Il11
entrez
16156
canonical
uniprot
P47873
canonical
ensembl
ENSMUSG00000004371
resolver
ensp
ENSMUSP00000092492
resolver
ensp
ENSMUSP00000131168
resolver
ensp
ENSMUSP00000157240
resolver
enst
ENSMUST00000094892
resolver
enst
ENSMUST00000163481
resolver
enst
ENSMUST00000234277
resolver
genesymbol
Il11
resolver
uniprot
A3KPB8
resolver
uniprot
F7A7F2
resolver
uniprot
Q3V0U3
resolver
uniprot_entry
A3KPB8_MOUSE
resolver
uniprot_entry
F7A7F2_MOUSE
resolver
uniprot_entry
IL11_MOUSE
resolver
uniprot_entry
Q3V0U3_MOUSE
resolver
amino_acid_sequence
MNCVCRLVLVVLSLWPDRVVAPGPPAGSPRVSSDPRADLDSAVLLTRSLLADTRQLAAQMRDKFPADGDHSLDSLPTLAMSAGTLGSLQLPGVLTRLRVDLMSYLRHVQWLRRAGGPSLKTLEPELGALQARLERLLRRLQLLMSRLALPQAAPDQPVIPLGPPASAWGSIRAAHAILGGLHLTLDWAVRGLLLLKTRL
uniprot
proteins
function
FUNCTION: Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:8913282). Also promotes the proliferation of hepatocytes in response to liver damage (PubMed:22253262). Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers (PubMed:10026196, PubMed:23948300). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3 (PubMed:22253262, PubMed:23948300). The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (By similarity). {ECO:0000250|UniProtKB:P20809, ECO:0000269|PubMed:10026196, ECO:0000269|PubMed:22253262, ECO:0000269|PubMed:23948300, ECO:0000269|PubMed:8913282}.
uniprot
proteins
mass_dalton
21522
uniprot
proteins
mutagenesis
MUTAGEN 168; /note="W->A: Slightly increases IL11RA binding. Abolishes interaction with IL6ST. Abolishes stimulation of cell proliferation."; /evidence="ECO:0000269|PubMed:10026196"; MUTAGEN 172; /note="R->A: No effect on IL11RA binding. Decreases stimulation of cell proliferation."; /evidence="ECO:0000269|PubMed:10026196"; MUTAGEN 190; /note="R->A: Srongly reduces IL11RA binding and stimulation of cell proliferation."; /evidence="ECO:0000269|PubMed:10026196"; MUTAGEN 193; /note="L->A: Impairs IL11RA binding and mildly reduces stimulation of cell proliferation."; /evidence="ECO:0000269|PubMed:10026196
uniprot
proteins
protein_family
IL-6 superfamily
uniprot
proteins
pubmed
10026196
uniprot
proteins
pubmed
22253262
uniprot
proteins
pubmed
23948300
uniprot
proteins
pubmed
8913282
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22253262}.
uniprot
proteins