Pde4a
entrez
18577
canonical
uniprot
O89084
canonical
ensembl
ENSMUSG00000032177
resolver
ensp
ENSMUSP00000003395
resolver
ensp
ENSMUSP00000037025
resolver
ensp
ENSMUSP00000111118
resolver
ensp
ENSMUSP00000160020
resolver
enst
ENSMUST00000249923
resolver
genesymbol
Pde4a
resolver
uniprot
A0AAQ4VMW1
resolver
uniprot
B2RTL2
resolver
uniprot
Q3TUD0
resolver
uniprot
Q8R078
resolver
uniprot
Q9JHQ4
resolver
uniprot
Q9QX48
resolver
uniprot
Q9QX49
resolver
uniprot
Q9QXI8
resolver
uniprot_entry
A0AAQ4VMW1_MOUSE
resolver
uniprot_entry
B2RTL2_MOUSE
resolver
uniprot_entry
PDE4A_MOUSE
resolver
uniprot_entry
Q3TUD0_MOUSE
resolver
uniprot_sec
Q8R078
resolver
uniprot_sec
Q9JHQ4
resolver
uniprot_sec
Q9QX48
resolver
uniprot_sec
Q9QX49
resolver
uniprot_sec
Q9QXI8
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform 2]: Inhibited by rolipram and diazepam. {ECO:0000269|PubMed:11267656}.
uniprot
proteins
amino_acid_sequence
MEPPAAPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERSEPERSPHRPIERADAVDTGDRPGLRTTRMSWPSSFHGTGTGGGSSRRLEAENGPTPSPGRSPLDSQASPGLMLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVASEAHGEDLIVTPFAQVLASLRNVRSNFSLLTNVPIPSNKRSPLGGPPSVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEIPSPTPRQRPFQQPPPAAVQQAQPMSQITGLKKLVHTGSLNINVPRFGVKTDQEDLLAQELENLSKWGLNIFCVSEYAGGRSLSCIMYTIFQERDLLKKFHIPVDTMMTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEENCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNRDWYHSAIRQSPSPTLEEEPGVLSDPALPDKFQFELTLEEEDEEDSLEVPGLPCTEETLLAPHDTRAQAMEQSKVKGQSPAVVEVAESLKQETASAHGAPEESAEAVGHSFSLETSILPDLRTLSPSEEAQGLLGLPSMAAEVEAPRDHLAAMRACSACSGTSGDNSAVISAPGRWGSGGDPA
uniprot
proteins
ec_number
3.1.4.53
uniprot
proteins
function
FUNCTION: Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11267656}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11267656}.
uniprot
proteins
mass_dalton
93558
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. {ECO:0000305|PubMed:11267656}.
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by CASP3. {ECO:0000250|UniProtKB:P27815}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE4 subfamily
uniprot
proteins
pubmed
10602991
uniprot
proteins
pubmed
11267656
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9677330
uniprot
proteins
sequence_length
844
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P27815}. Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:P27815}.
uniprot
proteins