OXA1L
entrez
5018
canonical
uniprot
Q15070
canonical
ensembl
ENSG00000155463
resolver
ensp
ENSP00000285848
resolver
ensp
ENSP00000483491
resolver
enst
ENST00000285848
resolver
genesymbol
OXA1L
resolver
hgnc
HGNC:8526
resolver
uniprot
A0A087X0L7
resolver
uniprot
B4DPA2
resolver
uniprot
J3KNA0
resolver
uniprot
Q2M1J6
resolver
uniprot_entry
J3KNA0_HUMAN
resolver
uniprot_entry
OXA1L_HUMAN
resolver
uniprot_entry
Q2M1J6_HUMAN
resolver
uniprot_sec
A0A087X0L7
resolver
uniprot_sec
B4DPA2
resolver
amino_acid_sequence
MAMGLMCGRRELLRLLQSGRRVHSVAGPSQWLGKPLTTRLLFPAAPCCCRPHYLFLAASGPRSLSTSAISFAEVQVQAPPVVAATPSPTAVPEVASGETADVVQTAAEQSFAELGLGSYTPVGLIQNLLEFMHVDLGLPWWGAIAACTVFARCLIFPLIVTGQREAARIHNHLPEIQKFSSRIREAKLAGDHIEYYKASSEMALYQKKHGIKLYKPLILPVTQAPIFISFFIALREMANLPVPSLQTGGLWWFQDLTVSDPIYILPLAVTATMWAVLELGAETGVQSSDLQWMRNVIRMMPLITLPITMHFPTAVFMYWLSSNLFSLVQVSCLRIPAVRTVLKIPQRVVHDLDKLPPREGFLESFKKGWKNAEMTRQLREREQRMRNQLELAARGPLRQTFTHNPLLQPGKDNPPNIPSSSSKPKSKYPWHDTLG
uniprot
proteins
function
FUNCTION: Mitochondrial membrane insertase that mediates the cotranslational insertion of integral membrane proteins into the mitochondrial inner membrane (PubMed:17936786, PubMed:33602856, PubMed:7991568). Essential for the activity and assembly of cytochrome oxidase (PubMed:17936786, PubMed:7991568). Required for the correct biogenesis of ATP synthase and complex I in mitochondria (PubMed:17936786, PubMed:7991568). {ECO:0000269|PubMed:17936786, ECO:0000269|PubMed:33602856, ECO:0000269|PubMed:7991568}.
uniprot
proteins
mass_dalton
48520
uniprot
proteins
mutagenesis
MUTAGEN 337; /note="A->C: Increases weakly homooligomer formation in presence or absence of magnesium."; /evidence="ECO:0000269|PubMed:20739282"; MUTAGEN 372; /note="A->C: Increases strongly homooligomer formation in presence of magnesium, but weakly in absence of magnesium."; /evidence="ECO:0000269|PubMed:20739282"; MUTAGEN 400; /note="T->C: Increases homooligomer formation in presence or absence of magnesium."; /evidence="ECO:0000269|PubMed:20739282"; MUTAGEN 426; /note="S->C: Increases weakly homooligomer formation in presence of magnesium, but strongly in absence of magnesium."; /evidence="ECO:0000269|PubMed:20739282
uniprot
proteins
protein_family
OXA1/ALB3/YidC family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17936786
uniprot
proteins
pubmed
20601428
uniprot
proteins
pubmed
20739282
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30201738
uniprot
proteins
pubmed
33243891
uniprot
proteins
pubmed
33602856
uniprot
proteins
pubmed
38199007
uniprot
proteins
pubmed
7991568
uniprot
proteins
pubmed
9247084
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:17936786, ECO:0000269|PubMed:33602856}; Multi-pass membrane protein {ECO:0000269|PubMed:33602856}.
uniprot
proteins
transmembrane_region
TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 261..281; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 300..320; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins