Nfat5
entrez
54446
canonical
uniprot
Q9WV30
canonical
ensembl
ENSMUSG00000003847
resolver
ensp
ENSMUSP00000075311
resolver
ensp
ENSMUSP00000076653
resolver
ensp
ENSMUSP00000116094
resolver
ensp
ENSMUSP00000127784
resolver
enst
ENSMUST00000077440
resolver
genesymbol
Nfat5
resolver
uniprot
A0A1U6URG8
resolver
uniprot
E9Q0P3
resolver
uniprot
E9Q6U2
resolver
uniprot
G5E8N9
resolver
uniprot
Q3UZ77
resolver
uniprot
Q91WY0
resolver
uniprot
Q9JLA1
resolver
uniprot_entry
A0A1U6URG8_MOUSE
resolver
uniprot_entry
NFAT5_MOUSE
resolver
uniprot_entry
Q3UZ77_MOUSE
resolver
uniprot_sec
E9Q0P3
resolver
uniprot_sec
E9Q6U2
resolver
uniprot_sec
G5E8N9
resolver
uniprot_sec
Q91WY0
resolver
uniprot_sec
Q9JLA1
resolver
amino_acid_sequence
MPSDFISLLSADLDLESPKSLYSRESVYDLLPKELQLPPPRETSVASMSQTSGGEAGSPPPAVVAADASSAPSSSSMGGACSSFTTSSSPTIYSTSVTDSKAMQVESCSSAVGVSNRGVSEKQLTGNTVQQHPSTPKRHTVLYISPPPEDLLDNSRMSCQDEGCGLESEQSCSMWMEDSPSNFSNMSTSSYNDNTEVPRKSRKRNPKQRPGVKRRDCEESNMDIFDADSAKAPHYVLSQLTTDNKGNSKAGNGTLDSQKGTGVKKSPMLCGQYPVKSEGKELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVKPHGFYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEARIGIAGSKKKSTRARLVFRVNITRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSDENSWKSEAEIDMELFHQNHLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDPAAGALNVNVKKEISSPARPCSFEEAMKAMKTTGCNVDKVTILPNALITPLISSSMIKTEDVTPMEVTSEKRSSPIFQTTKSIGSTQQTLETISNIAGGAPFSSPSSSSHLTPESENQQQLQPKAYNPETLTTIQTQDISQPGTFPAVSAASQLPSSDALLQQATQFQTREAQSRDTIQSDTVVNLSQLTEASQQQQSPLQEQAQTLQQQIPSNIFPSPSSVSQLQSTIQQLQAGSFTGSAAGGRSGSVDLVQQVLEAQQQLSSVLFSTPDGNENVQEQLNADIFQVSQIQNSVSPGMFSSAESAVHTRPDNLLPGRADSVHQQTENTLSNQQQQQQQQQQVMESSAAMVMEMQQSICQAAAQIQSELFPSAASASGSLQQSPVYQQPSHMMSALPTNEDMQMQCELFSSPPAASGNETSTTTTPQVATPGSTMFQTPSSGDGEETGAQAKQIQNSVFQTMVQMQRSGDSQPQVNLFSSTKNIMSVQNNGTQQQGNSLFQQGSEMMSLQSGNFLQQSSHSQAQLFHPQNPIADAQNLSQETQGSIFHSPNPIVHSQTSTASSEQLQPSMFHSQNTIAVLQGSSVPQDQQSPNIFLSQSSINNLQTNTVAQEEQISFFAAQNSISPLQSTSNTEQQAAFQQQPPISHIQTPILSQEQAQPSQQGLFQPQVALGSLPPNPMPQNQQGPIFQTQRPIVGMQSNSPSQEQQQQQQQQQQQQQQQQQQQQSILFSNQNAMATMASQKQPPPNMMFSPNQNPMASQEQQNQSIFHQQSNMAPMNQEQQPMQFQNQPTVSSLQNPGPTQSESPQTSLFHSSPQIQLVQGSPSSQDQQVTLFLSPASMSALQTSINQPDMQQSPLYSPQNNIPGIQGSTSSPQPQATLFHNTTGGTINQIQNSPGSSQQTSGMFLFGIQNNCSQLLTSGPATLPDQLMAINQQGQPQNEGQSSVTTLLSQQMPETSPLASSVNSSQNMEKIDLLVSLQSQGNNLTGSF
uniprot
proteins
function
FUNCTION: Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes (PubMed:11934689, PubMed:14983020). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (By similarity). Mediates the transcriptional response to hypertonicity (By similarity). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (By similarity). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (By similarity). {ECO:0000250|UniProtKB:O94916, ECO:0000269|PubMed:11934689, ECO:0000269|PubMed:14983020}.
uniprot
proteins
mass_dalton
165800
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-135 by CDK5 in response to osmotic stress; this phosphorylation mediates its rapid nuclear localization. {ECO:0000250|UniProtKB:O94916}.; PTM: Poly-ADP-ribosylated by PARP1 in response to DNA damage, promoting recruitment to sites of R-loop-associated DNA damage. {ECO:0000250|UniProtKB:O94916}.
uniprot
proteins
pubmed
10377394
uniprot
proteins
pubmed
11233530
uniprot
proteins
pubmed
11934689
uniprot
proteins
pubmed
14983020
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23233732
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
1534
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:11934689}. Cytoplasm {ECO:0000269|PubMed:11934689}. Chromosome {ECO:0000250|UniProtKB:O94916}. Note=Nuclear distribution increases under hypertonic conditions (PubMed:11934689). Recruited to sites of R-loop-associated DNA damage following poly-ADP-ribosylation by PARP1 (By similarity). {ECO:0000250|UniProtKB:O94916, ECO:0000269|PubMed:11934689}.
uniprot
proteins