HPN
entrez
3249
canonical
uniprot
P05981
canonical
ensembl
ENSG00000105707
resolver
ensp
ENSP00000262626
resolver
ensp
ENSP00000376060
resolver
ensp
ENSP00000500664
resolver
ensp
ENSP00000500909
resolver
ensp
ENSP00000533249
resolver
ensp
ENSP00000533252
resolver
ensp
ENSP00000533253
resolver
ensp
ENSP00000533259
resolver
ensp
ENSP00000533260
resolver
ensp
ENSP00000533262
resolver
ensp
ENSP00000533266
resolver
ensp
ENSP00000533268
resolver
ensp
ENSP00000533269
resolver
ensp
ENSP00000533272
resolver
ensp
ENSP00000533274
resolver
ensp
ENSP00000533281
resolver
ensp
ENSP00000533283
resolver
enst
ENST00000262626
resolver
enst
ENST00000392226
resolver
enst
ENST00000672452
resolver
enst
ENST00000673426
resolver
enst
ENST00000863190
resolver
enst
ENST00000863193
resolver
enst
ENST00000863194
resolver
enst
ENST00000863200
resolver
enst
ENST00000863201
resolver
enst
ENST00000863203
resolver
enst
ENST00000863207
resolver
enst
ENST00000863209
resolver
enst
ENST00000863210
resolver
enst
ENST00000863213
resolver
enst
ENST00000863215
resolver
enst
ENST00000863222
resolver
enst
ENST00000863224
resolver
genesymbol
HPN
resolver
genesymbol_syn
TMPRSS1
resolver
hgnc
HGNC:5155
resolver
uniprot
A0A140VJK9
resolver
uniprot
B2RDS4
resolver
uniprot
B7Z1L4
resolver
uniprot_entry
A0A140VJK9_HUMAN
resolver
uniprot_entry
B7Z1L4_HUMAN
resolver
uniprot_entry
HEPS_HUMAN
resolver
uniprot_sec
B2RDS4
resolver
amino_acid_sequence
MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
uniprot
proteins
ec_number
3.4.21.106
uniprot
proteins
function
FUNCTION: Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:15839837, PubMed:21875933). Plays a role in cell growth and maintenance of cell morphology (PubMed:21875933, PubMed:8346233). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890). {ECO:0000269|PubMed:15839837, ECO:0000269|PubMed:21875933, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:26673890, ECO:0000269|PubMed:8346233}.
uniprot
proteins
mass_dalton
45011
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
12962630
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15839837
uniprot
proteins
pubmed
1885621
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21875933
uniprot
proteins
pubmed
24227843
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26673890
uniprot
proteins
pubmed
2835076
uniprot
proteins
pubmed
8346233
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1885621}; Single-pass type II membrane protein {ECO:0000269|PubMed:1885621}. Apical cell membrane {ECO:0000269|PubMed:26673890}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..44; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins