Cldn2
entrez
12738
canonical
uniprot
O88552
canonical
ensembl
ENSMUSG00000047230
resolver
ensp
ENSMUSP00000054219
resolver
ensp
ENSMUSP00000211181
resolver
enst
ENSMUST00000054889
resolver
genesymbol
Cldn2
resolver
uniprot_entry
CLD2_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: The channel permeability is down-regulated at acidic pH. {ECO:0000269|PubMed:19114638}.
uniprot
proteins
amino_acid_sequence
MASLGVQLVGYILGLLGLLGTSIAMLLPNWRTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAMSSLACIISVVGMRCTVFCQDSRAKDRVAVVGGVFFILGGILGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISALFSLVAGVILCFSCSPQGNRTNYYDGYQAQPLATRSSPRSAQQPKAKSEFNSYSLTGYV
uniprot
proteins
function
FUNCTION: Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:10508613, PubMed:12432083, PubMed:19114638, PubMed:23677799). In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and clear enteric pathogens as part of mucosal immune response (PubMed:23089202, PubMed:28618266). In kidney, allows passive sodium and calcium reabsorption across proximal tubules from the lumen back to the bloodstream (PubMed:27214555, PubMed:32149733). In the hepatobiliary tract, allows paracellular water and cation fluxes in the hepatic perivenous areas and biliary epithelium to generate bile flow and maintain osmotic gradients (PubMed:25068494). {ECO:0000269|PubMed:10508613, ECO:0000269|PubMed:12432083, ECO:0000269|PubMed:19114638, ECO:0000269|PubMed:23089202, ECO:0000269|PubMed:23677799, ECO:0000269|PubMed:25068494, ECO:0000269|PubMed:27214555, ECO:0000269|PubMed:28618266, ECO:0000269|PubMed:32149733}.
uniprot
proteins
mass_dalton
24484
uniprot
proteins
mutagenesis
MUTAGEN 53; /note="E->Q: Does not affect the channel activity."; /evidence="ECO:0000269|PubMed:19114638"; MUTAGEN 54; /note="C->A: Disrupts trafficking to tight junction."; /evidence="ECO:0000269|PubMed:23677799"; MUTAGEN 54; /note="C->S: Does not affect trafficking to tight junction. Causes loss of pore formation. Impairs transepithelial conductance. Impairs sodium paracellular permeability."; /evidence="ECO:0000269|PubMed:23677799"; MUTAGEN 64; /note="C->A: Disrupts trafficking to tight junction."; /evidence="ECO:0000269|PubMed:23677799"; MUTAGEN 64; /note="C->S: Does not affect trafficking to tight junction. Causes loss of pore formation. Impairs transepithelial conductance. Impairs sodium paracellular permeability."; /evidence="ECO:0000269|PubMed:23677799"; MUTAGEN 65; /note="D->N: Markedly decreases cation permeability."; /evidence="ECO:0000269|PubMed:19114638"; MUTAGEN 76; /note="D->N: Does not affect the channel activity."; /evidence="ECO:0000269|PubMed:19114638
uniprot
proteins
post_translational_modification
PTM: The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking. {ECO:0000269|PubMed:23677799}.
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
10508613
uniprot
proteins
pubmed
10562289
uniprot
proteins
pubmed
10601346
uniprot
proteins
pubmed
11934881
uniprot
proteins
pubmed
12432083
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19114638
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23089202
uniprot
proteins
pubmed
23677799
uniprot
proteins
pubmed
25068494
uniprot
proteins
pubmed
27214555
uniprot
proteins
pubmed
28618266
uniprot
proteins
pubmed
32149733
uniprot
proteins
pubmed
9647647
uniprot
proteins
sequence_length
230
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:11934881, ECO:0000269|PubMed:12432083, ECO:0000269|PubMed:23677799, ECO:0000269|PubMed:32149733, ECO:0000269|PubMed:9647647}. Cell membrane {ECO:0000269|PubMed:11934881}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins