ERC1
entrez
23085
canonical
uniprot
Q8IUD2
canonical
ensembl
ENSG00000082805
resolver
ensp
ENSP00000347621
resolver
ensp
ENSP00000354158
resolver
ensp
ENSP00000380386
resolver
ensp
ENSP00000410064
resolver
ensp
ENSP00000438546
resolver
ensp
ENSP00000442739
resolver
ensp
ENSP00000445336
resolver
ensp
ENSP00000565680
resolver
ensp
ENSP00000565681
resolver
ensp
ENSP00000565682
resolver
ensp
ENSP00000565689
resolver
ensp
ENSP00000565690
resolver
ensp
ENSP00000586712
resolver
ensp
ENSP00000620383
resolver
ensp
ENSP00000620384
resolver
ensp
ENSP00000620386
resolver
ensp
ENSP00000620387
resolver
ensp
ENSP00000704603
resolver
ensp
ENSP00000776029
resolver
enst
ENST00000355446
resolver
enst
ENST00000542302
resolver
enst
ENST00000546231
resolver
enst
ENST00000950324
resolver
enst
ENST00000950325
resolver
enst
ENST00000950327
resolver
genesymbol
ERC1
resolver
genesymbol_syn
ELKS
resolver
genesymbol_syn
KIAA1081
resolver
genesymbol_syn
RAB6IP2
resolver
hgnc
HGNC:17072
resolver
uniprot
A2RU77
resolver
uniprot
A7E295
resolver
uniprot
D3DUP7
resolver
uniprot
D3DUP8
resolver
uniprot
G8JLD3
resolver
uniprot
Q6NVK2
resolver
uniprot
Q8IUD3
resolver
uniprot
Q8IUD4
resolver
uniprot
Q8IUD5
resolver
uniprot
Q8NAS1
resolver
uniprot
Q9NXN5
resolver
uniprot
Q9UIK7
resolver
uniprot
Q9UPS1
resolver
uniprot
X6RLX0
resolver
uniprot
X6RM00
resolver
uniprot_entry
G8JLD3_HUMAN
resolver
uniprot_entry
RB6I2_HUMAN
resolver
uniprot_entry
X6RLX0_HUMAN
resolver
uniprot_entry
X6RM00_HUMAN
resolver
uniprot_sec
A2RU77
resolver
uniprot_sec
A7E295
resolver
uniprot_sec
D3DUP7
resolver
uniprot_sec
D3DUP8
resolver
uniprot_sec
Q6NVK2
resolver
uniprot_sec
Q8IUD3
resolver
uniprot_sec
Q8IUD4
resolver
uniprot_sec
Q8IUD5
resolver
uniprot_sec
Q8NAS1
resolver
uniprot_sec
Q9NXN5
resolver
uniprot_sec
Q9UIK7
resolver
uniprot_sec
Q9UPS1
resolver
amino_acid_sequence
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQVVNALEESS
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving ERC1/RAB6IP2 is found in papillary thyroid carcinomas (PTCs). Translocation t(10;12)(q11;p13) involving RET. In vitro, isoform 1, isoform 3 and isoform 5 participating in a ERC1-RET fusion protein activate tyrosine-protein kinase activity. {ECO:0000269|PubMed:10337992}.
uniprot
proteins
function
FUNCTION: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}.
uniprot
proteins
mass_dalton
128086
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in an N-terminal region by SRPK1 and/or SRPK2. {ECO:0000250|UniProtKB:Q811U3}.
uniprot
proteins
pubmed
10337992
uniprot
proteins
pubmed
10470851
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12203787
uniprot
proteins
pubmed
12923177
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15218148
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24120883
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27224062
uniprot
proteins
pubmed
27410476
uniprot
proteins
sequence_length
1116
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27224062}. Cytoplasm {ECO:0000250|UniProtKB:Q811U3}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q811U3}. Cell projection, podosome {ECO:0000250|UniProtKB:Q99MI1}. Note=Recruited on Golgi membranes by RAB6A in a GTP-dependent manner (By similarity). Localized to the cortex of myotube podosomes (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q99MI1}.
uniprot
proteins