Skic3
entrez
218343
canonical
uniprot
F8VPK0
canonical
ensembl
ENSMUSG00000033991
resolver
ensp
ENSMUSP00000089045
resolver
ensp
ENSMUSP00000153521
resolver
ensp
ENSMUSP00000213610
resolver
ensp
ENSMUSP00000213614
resolver
ensp
ENSMUSP00000213618
resolver
enst
ENSMUST00000091466
resolver
enst
ENSMUST00000224386
resolver
genesymbol
Skic3
resolver
uniprot_entry
SKI3_MOUSE
resolver
amino_acid_sequence
MSSKEVKTALKSARDAIRNKEYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQGAYKKAAELEPEQLLAWQGLASLYEKCNQVNAKDDLPGVYQKLLDLYESADRQKWCDVCKKLVALYHQEKKHLEVARTWHRLIKTRQEDGADRQELYELWRKLSQLLAENIEDQNNETQQMLLTAFENALDLADNIPSEDHQVLYRNFIQCLSKFPHETTKLKKACEEMIAIYPTVQYPLEVICLYLIDSGSLTSEGHQYCCKLVEMNSKSGPGLIGLGIIALQDKKYEDAVRHLTEGLKESPVCIAGWCHLAEAQVKMHRPKEAILSCNQALKTIDNFGASGGNLHQKNLCLRLKAEALLKLSDGASSEEAVRTLDQVSDVDNTPGLLVLQGLACLNTGAVDKATKIMEDLVTSYPDLAEAHALEGRVHFTKKDYVQAEVSFQRALEKDAEVAEYHYQLGLTYWFMGEETRKDKTKALTHFLKAARLDAHMGKVFCYLGHYYRDVAGDRNRARGCYRKAFELDDNDAESGAAAVDLSLELEDTETALAILTAVTQKASAGAAKWAWLRRGLYHLKAGQHSQAVADLQAALRADPKDCNCWESLGEAYLSRGGYTTALKSFMKASELNPDSTYSVFKVAAIQQILGRYSEAIAQYQLIIKMKEDYVPALKGLGECHLLLGKVALVDFLDGKAVDYVEQALGYFTRALQHRADVSCLWKLVGDACTCLHPVSPSKVHVHVLGALLGQKEGQEVLKKEELLSLGGRCYGRALKLMSTSNTWCDLGINYYRQVQHLAETGSSMSDLTELLEKSLHCLKKAVRLDSNNHLHWNALGVVACYRGVGNYALAQHCFIKSIQAEQINAAAWTNLGVLYLATENIEQAHEAFKMAQSLDPSYLLCWIGQALIAERVGSYDTMDLFRHTTELSMHTEGAIGYAYWVCTTLQDKSNRETELYQYNILEMNAIPAAQGVLCKYVERIQNSASAFTMLGYLNEHLQLKKEAAEAYQRATTLLHSAEDQNTYNVAVRNWGRLLCSIGDYDRAIQAFKSTPLVELEDIIGFALALFMKGLYKESGSAYERALAVCKSEQDKAHILTAMAIVEYKQGKMDAAKSFLFKCSILKEPTAESLQALCALGLAMRDATLSKAALNELLKHIKRRNDYHSCLLMSAIYALQGHSVAVQRQVAKAVHSNPADPALWSLLSRIVAQYTQRSAKGGAVAGNVAHILDLNHGKKALLYTAVNQLAMGSSTAEDKSNTALKTIQKAAFLSPDDPAVWAGLMAACHADDKLALLNNTQPKRVDLYLALRSAVAASLKDKEILQNYNQSLEKWSFSQVVTGLIDTGKTSEAESLCTQSLKSNPDQPAVILLLRQVQCMSLLESQKPLPDAVLEELQKTVMSNSTSVPAWQWLAQVYQSQGMMGAAEMCYRKSLQVASQQGNWSGKLSSLLKLALLALEVCMANVSGDHWSSLVQEATSEALKVCFSPLAVFLQALLQFNRKMGARETRRLLERIVYQTGYPSSIVSAARWYLLRHLYAKDDPELIDVLVRNAETHGDKRILELNRKLSAQ
uniprot
proteins
function
FUNCTION: Component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). {ECO:0000250|UniProtKB:Q6PGP7}.
uniprot
proteins
mass_dalton
173942
uniprot
proteins
protein_family
SKI3 family
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
1563
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6PGP7}. Nucleus {ECO:0000250|UniProtKB:Q6PGP7}.
uniprot
proteins