CATSPER1
entrez
117144
canonical
uniprot
Q8NEC5
canonical
ensembl
ENSG00000175294
resolver
ensp
ENSP00000309052
resolver
enst
ENST00000312106
resolver
genesymbol
CATSPER1
resolver
hgnc
HGNC:17116
resolver
uniprot
Q96P76
resolver
uniprot_entry
CTSR1_HUMAN
resolver
uniprot_sec
Q96P76
resolver
activity_regulation
ACTIVITY REGULATION: The CatSper calcium channel is indirectly activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2 (PubMed:21412338, PubMed:21412339, PubMed:26989199). The CatSper calcium channel is directly inhibited by endocannabinoid 2-arachidonoylglycerol (2AG) (PubMed:26989199). Indirect activation by progesterone takes place via the following mechanism: progesterone binds and activates the acylglycerol lipase ABHD2, which in turn mediates hydrolysis of 2AG inhibitor, relieving inhibition of the CatSper channel (PubMed:26989199). The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers (PubMed:21412338, PubMed:21412339). Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH (PubMed:21412338, PubMed:21412339). {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339, ECO:0000269|PubMed:26989199}.
uniprot
proteins
amino_acid_sequence
MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELHHHGVPHQRGESHHPPEFQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQRDGRRHHDGSQYGGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYLPHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKSPHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYHQHQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSAHSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQAAVIDEIVDTTFEAGEEDFRN
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 7 (SPGF7) [MIM:612997]: An infertility disorder characterized by non-motile sperm or sperm motility below the normal threshold, low sperm count, increased abnormally structured spermatozoa, and reduced semen volume. {ECO:0000269|PubMed:19344877}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.
uniprot
proteins
mass_dalton
90091
uniprot
proteins
protein_family
Cation channel sperm-associated (TC 1.A.1.19) family
uniprot
proteins
pubmed
11595941
uniprot
proteins
pubmed
14688170
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16625279
uniprot
proteins
pubmed
16740636
uniprot
proteins
pubmed
17347248
uniprot
proteins
pubmed
19344877
uniprot
proteins
pubmed
21412338
uniprot
proteins
pubmed
21412339
uniprot
proteins
pubmed
26989199
uniprot
proteins
sequence_length
780
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:16625279}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91ZR5}. Note=Specifically located in the principal piece of the sperm tail. {ECO:0000269|PubMed:16625279}.
uniprot
proteins
transmembrane_region
TRANSMEM 448..469; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:Q91ZR5"; TRANSMEM 479..500; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:Q91ZR5"; TRANSMEM 509..531; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:Q91ZR5"; TRANSMEM 541..563; /note="Helical; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:Q91ZR5"; TRANSMEM 582..604; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:Q91ZR5"; TRANSMEM 646..671; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:Q91ZR5
uniprot
proteins