Slpi
entrez
20568
canonical
uniprot
P97430
canonical
ensembl
ENSMUSG00000017002
resolver
ensp
ENSMUSP00000104992
resolver
enst
ENSMUST00000109367
resolver
genesymbol
Slpi
resolver
uniprot
O09081
resolver
uniprot
O09082
resolver
uniprot
Q548X8
resolver
uniprot_entry
Q548X8_MOUSE
resolver
uniprot_entry
SLPI_MOUSE
resolver
uniprot_sec
O09081
resolver
uniprot_sec
O09082
resolver
amino_acid_sequence
MKSCGLLPFTVLLALGILAPWTVEGGKNDAIKIGACPAKKPAQCLKLEKPQCRTDWECPGKQRCCQDACGSKCVNPVPIRKPVWRKPGRCVKTQARCMMLNPPNVCQRDGQCDGKYKCCEGICGKVCLPPM
uniprot
proteins
function
FUNCTION: Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:9126337). Modulates the innate immune response after bacterial infection (PubMed:12615907). Contributes to regulate the inflammatory and immune responses to the intracellular parasite L.major (PubMed:25030421). Down-regulates responses to bacterial lipopolysaccharide (LPS) (PubMed:12615907, PubMed:25030421, PubMed:9039268). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:11017147, PubMed:12615907). Has antimicrobial activity against mycobacteria, but not against salmonella (PubMed:18322212). Contributes to normal resistance against infection by M.tuberculosis (PubMed:18322212). Required for normal resistance to L.major (PubMed:25030421). Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (PubMed:11017147, PubMed:25030421). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (By similarity). {ECO:0000250|UniProtKB:P03973, ECO:0000269|PubMed:11017147, ECO:0000269|PubMed:12615907, ECO:0000269|PubMed:18322212, ECO:0000269|PubMed:25030421, ECO:0000269|PubMed:9039268, ECO:0000269|PubMed:9126337, ECO:0000269|PubMed:9351627, ECO:0000305}.
uniprot
proteins
mass_dalton
14308
uniprot
proteins
mutagenesis
MUTAGEN 39..40; /note="KK->DD: Loss of antimicrobial activity."; /evidence="ECO:0000269|PubMed:18322212"; MUTAGEN 92; /note="K->D: Loss of antimicrobial activity; when associated with A-96."; /evidence="ECO:0000269|PubMed:18322212"; MUTAGEN 96; /note="R->D: Loss of antimicrobial activity; when associated with A-92."; /evidence="ECO:0000269|PubMed:18322212
uniprot
proteins
pubmed
11017147
uniprot
proteins
pubmed
12526812
uniprot
proteins
pubmed
12615907
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18322212
uniprot
proteins
pubmed
25030421
uniprot
proteins
pubmed
9039268
uniprot
proteins
pubmed
9126337
uniprot
proteins
pubmed
9351627
uniprot
proteins
sequence_length
131
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18322212, ECO:0000269|PubMed:9126337}.
uniprot
proteins