Terf2
entrez
21750
canonical
uniprot
O35144
canonical
ensembl
ENSMUSG00000031921
resolver
ensp
ENSMUSP00000065586
resolver
ensp
ENSMUSP00000068948
resolver
ensp
ENSMUSP00000112126
resolver
ensp
ENSMUSP00000118759
resolver
ensp
ENSMUSP00000213288
resolver
ensp
ENSMUSP00000213289
resolver
ensp
ENSMUSP00000213290
resolver
enst
ENSMUST00000068388
resolver
enst
ENSMUST00000133925
resolver
genesymbol
Terf2
resolver
genesymbol_syn
Trf2
resolver
uniprot
D3YVG5
resolver
uniprot
D3YZ08
resolver
uniprot
E9QM06
resolver
uniprot
Q80VE2
resolver
uniprot
Q8BQJ9
resolver
uniprot_entry
D3YZ08_MOUSE
resolver
uniprot_entry
E9QM06_MOUSE
resolver
uniprot_entry
TERF2_MOUSE
resolver
uniprot_sec
D3YVG5
resolver
uniprot_sec
Q80VE2
resolver
uniprot_sec
Q8BQJ9
resolver
amino_acid_sequence
MAAGAGTAGPASGPGVVRDPMASQPRKRPSREGGEGGEGERRSNTMAGGGGSSDSSGRAASRRASRSGGRARRGRHEPGLGGAAERGAGEARLEEAVNRWVLKFYFHEALRAFRSSRYRDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTDSMVESSRKLVKEAAVIICIKNKEFEKASKILKKYMSKDPTTQKLRTDLLNIIREKNLAHPVIQNFSYEVFQQKMLRFLESHLDDTEPYLLTMAKKALKSESAASSTMREEKHPEPVEKPLREPPSRQPQNPPATIGIRTLKAAFKALSTAQDSEAAFAKLDQKDLVLANLASPSSPAHKHKRPRKDEHESAAPAEGEGGSDRQPRNSPMTISRLLLEEDSQSTEPSPGLNSSHKAMSASKPRALNQPHPGEKKPKASKDKWNSPNGLEEKEVWLEEDQLFEVQAPGEDRSSSLTRKQKWTIEESEWVKDGVRKYGEGNWAAISKSYPFVNRTAVMIKDRWRTMKKLGMN
uniprot
proteins
function
FUNCTION: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes (PubMed:20339076, PubMed:20619712, PubMed:20622870, PubMed:28216226). In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo (By similarity). Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (By similarity). Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (By similarity). Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair (By similarity). Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo (PubMed:28216226). Preferentially binds to positive supercoiled DNA (By similarity). Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology (By similarity). Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length (PubMed:20339076, PubMed:20619712, PubMed:20622870). {ECO:0000250|UniProtKB:Q15554, ECO:0000269|PubMed:20339076, ECO:0000269|PubMed:20619712, ECO:0000269|PubMed:20622870, ECO:0000269|PubMed:28216226}.
uniprot
proteins
mass_dalton
60263
uniprot
proteins
mutagenesis
MUTAGEN 165; /note="F->A: Abolishes interaction with DCLRE1B/Apollo, leading to activate the ATM signaling pathway."; /evidence="ECO:0000269|PubMed:20619712"; MUTAGEN 335..336; /note="AF->SS: Abolishes interaction with TERF2IP/RAP1 but does not affect protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair."; /evidence="ECO:0000269|PubMed:20339076
uniprot
proteins
post_translational_modification
PTM: Phosphorylated upon DNA damage, most probably by ATM. Phosphorylated TERF2 is not bound to telomeric DNA, and rapidly localizes to damage sites (By similarity). {ECO:0000250|UniProtKB:Q15554}.; PTM: Methylated by PRMT1 at multiple arginines within the N-terminal Arg-rich region. Methylation may control association with telomeres (By similarity). {ECO:0000250|UniProtKB:Q15554}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20339076
uniprot
proteins
pubmed
20619712
uniprot
proteins
pubmed
20622870
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28216226
uniprot
proteins
pubmed
9326950
uniprot
proteins
sequence_length
541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:20339076}. Chromosome, telomere {ECO:0000269|PubMed:20339076}. Note=Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase. {ECO:0000269|PubMed:20339076}.
uniprot
proteins