MOSPD2
entrez
158747
canonical
uniprot
Q8NHP6
canonical
ensembl
ENSG00000130150
resolver
ensp
ENSP00000369860
resolver
ensp
ENSP00000473271
resolver
enst
ENST00000482354
resolver
genesymbol
MOSPD2
resolver
hgnc
HGNC:28381
resolver
uniprot
Q8N3H2
resolver
uniprot
Q8NA83
resolver
uniprot
R4GMN1
resolver
uniprot_entry
MSPD2_HUMAN
resolver
uniprot_entry
R4GMN1_HUMAN
resolver
uniprot_sec
Q8N3H2
resolver
uniprot_sec
Q8NA83
resolver
amino_acid_sequence
MAENHAQNKAKLISETRRRFEAEYVTDKSDKYDARDVERLQQDDNWVESYLSWRHNIVDETLKMLDESFQWRKEISVNDLNESSIPRWLLEIGVIYLHGYDKEGNKLFWIRVKYHVKDQKTILDKKKLIAFWLERYAKRENGKPVTVMFDLSETGINSIDMDFVRFIINCFKVYYPKYLSKIVIFDMPWLMNAAFKIVKTWLGPEAVSLLKFTSKNEVQDYVSVEYLPPHMGGTDPFKYSYPPLVDDDFQTPLCENGPITSEDETSSKEDIESDGKETLETISNEEQTPLLKKINPTESTSKAEENEKVDSKVKAFKKPLSVFKGPLLHISPAEELYFGSTESGEKKTLIVLTNVTKNIVAFKVRTTAPEKYRVKPSNSSCDPGASVDIVVSPHGGLTVSAQDRFLIMAAEMEQSSGTGPAELTQFWKEVPRNKVMEHRLRCHTVESSKPNTLTLKDNAFNMSDKTSEDICLQLSRLLESNRKLEDQVQRCIWFQQLLLSLTMLLLAFVTSFFYLLYS
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins (PubMed:29858488, PubMed:33124732, PubMed:35389430). In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis (PubMed:35389430). The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs (PubMed:35389430). Promotes migration of primary monocytes and neutrophils, in response to various chemokines (PubMed:28137892). {ECO:0000269|PubMed:28137892, ECO:0000269|PubMed:29858488, ECO:0000269|PubMed:33124732, ECO:0000269|PubMed:35389430}.
uniprot
proteins
mass_dalton
59746
uniprot
proteins
mutagenesis
MUTAGEN 201; /note="W->E: Does not affect endoplasmic reticulum distribution. Does not impair the folding of the CRAL-TRIO domain. Decreases lipid droplets (LDs) binding."; /evidence="ECO:0000269|PubMed:35389430"; MUTAGEN 363; /note="K->L: Partially affects the binding of the FFAT motif of OSBPL1A. Partially affects the binding of the phosphorylated FFAT motif of STARD3."; /evidence="ECO:0000269|PubMed:33124732"; MUTAGEN 404; /note="R->D: Prevents binding to the FFAT motif of target proteins STARD3, STARD3NL, RMDN3, OSBPL1A and CERT1 and impairs recruitment to interorganelle membrane contacts; when associated with D-406. Significantly increases the recruitment at the periphery of lipid droplets, both in the presence and in the absence of oleic acid (OA); when associated with D-406. Does not affect endoplasmic reticulum membrane location; when associated with D-406."; /evidence="ECO:0000269|PubMed:29858488, ECO:0000269|PubMed:35389430"; MUTAGEN 406; /note="L->D: Prevents binding to the FFAT motif of target proteins STARD3, STARD3NL, RMDN3, OSBPL1A and CERT1 and impairs recruitment to interorganelle membrane contacts; when associated with D-404. Significantly increases the recruitment at the periphery of lipid droplets, both in the presence and in the absence of oleic acid (OA); when associated with D-404. Does not affect endoplasmic reticulum membrane location; when associated with D-404."; /evidence="ECO:0000269|PubMed:29858488, ECO:0000269|PubMed:35389430"; MUTAGEN 493..518; /note="Missing: Loss of localization to endoplasmic reticulum membrane."; /evidence="ECO:0000269|PubMed:29858488
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
28137892
uniprot
proteins
pubmed
29858488
uniprot
proteins
pubmed
33124732
uniprot
proteins
pubmed
35389430
uniprot
proteins
sequence_length
518
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:28137892, ECO:0000269|PubMed:29858488, ECO:0000269|PubMed:35389430}; Single-pass type IV membrane protein {ECO:0000269|PubMed:29858488}. Note=Localization to contact sites involving the endoplasmic reticulum and several organelles is regulated by interaction with proteins containing FFAT motif (PubMed:29858488). Dynamically distributes between specific subdomains of the endoplasmic reticulum (ER): ER membranes in contact with lipid droplets (LDs) and the remainder of the ER (PubMed:35389430). {ECO:0000269|PubMed:29858488, ECO:0000269|PubMed:35389430}.
uniprot
proteins
transmembrane_region
TRANSMEM 497..518; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000269|PubMed:29858488, ECO:0000269|PubMed:35389430
uniprot
proteins