GPR142
entrez
350383
canonical
uniprot
Q7Z601
canonical
ensembl
ENSG00000257008
resolver
ensp
ENSP00000335158
resolver
ensp
ENSP00000464632
resolver
genesymbol
GPR142
resolver
genesymbol_syn
GPRG1B
resolver
genesymbol_syn
PGR2
resolver
hgnc
HGNC:20088
resolver
uniprot
A4CYJ8
resolver
uniprot
J3QSD0
resolver
uniprot
Q86SL3
resolver
uniprot_entry
GP142_HUMAN
resolver
uniprot_sec
A4CYJ8
resolver
uniprot_sec
J3QSD0
resolver
uniprot_sec
Q86SL3
resolver
amino_acid_sequence
MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
uniprot
proteins
function
FUNCTION: Highly selective G protein-coupled receptor for aromatic amino acids specifically L-Tryptophan (L-Trp) and L-Phenylalanine (L-Phe), with L-Trp being the most potent and efficacious agonist (PubMed:27104960, PubMed:27322810). GPR142 agonists triggers the activation of both GNAQ/G(q) and GNAI1/G(i)-coupled signaling pathways (PubMed:27104960). L-Trp stimulates glucose-induced insulin secretion and triggers G(q)-mediated signaling (By similarity). GPR142 appears to have a role as a sensor of aromatic essential amino acids controlling the secretion of both insulin in the pancreas and other gastrointestinal hormones including glucagon but also CCK and incretin in the gastrointestinal-tract, contributing to the control of glucose homeostasis by coordinating pancreatic and gut hormone secretion (By similarity). {ECO:0000250|UniProtKB:Q7TQN9, ECO:0000269|PubMed:27104960, ECO:0000269|PubMed:27322810}.
uniprot
proteins
mass_dalton
51106
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
14623098
uniprot
proteins
pubmed
15845401
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
27104960
uniprot
proteins
pubmed
27322810
uniprot
proteins
pubmed
30472415
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 153..173; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 234..254; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 279..299; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 317..337; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 358..378; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 398..418; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins