Slc9a8
entrez
311651
canonical
uniprot
Q4L208
canonical
genesymbol
Slc9a8
resolver
genesymbol_syn
Nhe8
resolver
uniprot_entry
SL9A8_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Expression and activity are regulated by acid media by increasing the rate of trafficking to the apical membrane (PubMed:22088432). Inhibited by HOE694 and S3226 (PubMed:18209477). {ECO:0000269|PubMed:18209477, ECO:0000269|PubMed:22088432}.
uniprot
proteins
amino_acid_sequence
MAEEFSNTTHESFNFTLHTTLGVTTKLVLPTPAEPILPVQTGEQAQQEEQSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKVIEFKKLANWKEEEMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRKHMSDVSGWQTFSQALGYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLGLEPMEKRQLIGTTTIIIVLFTILLLGGSTMPLIRLVDIEDARARRRSKKDVNLSKTEKMGNAIESEHLSELTEEEYEAHYIRQQDLKGFMWLDAKYLNPFFTRRLTQEDLHHGRIQMKSLTNKWYEEVRQGPSGSEDDEQELF
uniprot
proteins
function
FUNCTION: Na(+)/H(+) antiporter. Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Acts as an Na(+)/H(+) exchanger in the trans-Golgi. Contributes to the regulation of pH regulation of Golgi apparatus, and consequently, in protein trafficking and endosomal morphology (By similarity). In germ cells, plays a crucial role in acrosome biogenesis and sperm development, probably by playing a role in the fusion of the Golgi-derived vesicles that form the acrosomal cap (By similarity). Can also be active at the cell surface of specialized cells (PubMed:22088432). In the small intestine, at the cell membrane, plays a major physiological role in transepithelial absorption of Na(+) and regulates intracellular pH homeostasis of intestinal epithelial cells (PubMed:18209477, PubMed:34288721). Acts as an important regulator of mucosal integrity in the intestine and in the stomach, could mediate the pH fluctuation necessary for mucin exocytosis or assist membrane trafficking of other proteins. Plays a role in photoreceptor survival and in the maintenance of intracellular pH homeostasis in retinal pigment epithelium (RPE cells) (By similarity). {ECO:0000250|UniProtKB:Q8R4D1, ECO:0000250|UniProtKB:Q9Y2E8, ECO:0000269|PubMed:18209477, ECO:0000269|PubMed:22088432, ECO:0000269|PubMed:34288721}.
uniprot
proteins
mass_dalton
64609
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
12409279
uniprot
proteins
pubmed
15522984
uniprot
proteins
pubmed
15731506
uniprot
proteins
pubmed
18209477
uniprot
proteins
pubmed
22088432
uniprot
proteins
pubmed
34288721
uniprot
proteins
sequence_length
575
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Y2E8}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9Y2E8}; Multi-pass membrane protein {ECO:0000255}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:Q9Y2E8}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:12409279, ECO:0000269|PubMed:15522984, ECO:0000269|PubMed:15731506, ECO:0000269|PubMed:22088432, ECO:0000269|PubMed:34288721}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8R4D1}. Note=Intracellular versus plasma membrane-resident location may vary with cell type. Mainly localized to the mid- to trans-Golgi compartments but a proportion is also localized to multivesicular bodies (By similarity). Expressed in the apical membrane of the epithelial cells in the small intestine, along the crypt villus axis (PubMed:22088432). Recruitment to the plasma membrane upon acid stimulation (PubMed:22088432). In the kidney localizes to the apical membrane and coated pit regions (PubMed:15522984). {ECO:0000250|UniProtKB:Q9Y2E8, ECO:0000269|PubMed:15522984, ECO:0000269|PubMed:22088432}.
uniprot
proteins
transmembrane_region
TRANSMEM 54..74; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 78..98; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 348..368; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 373..393; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 411..431; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 445..465; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins