Tln1
entrez
21894
canonical
uniprot
P26039
canonical
ensembl
ENSMUSG00000028465
resolver
ensp
ENSMUSP00000030187
resolver
enst
ENSMUST00000030187
resolver
genesymbol
Tln1
resolver
genesymbol_syn
Tln
resolver
genesymbol_syn
mKIAA1027
resolver
uniprot
A2AIM8
resolver
uniprot
Q0V930
resolver
uniprot
Q3UHS6
resolver
uniprot
Q80TM2
resolver
uniprot
Q8VEF0
resolver
uniprot_entry
Q0V930_MOUSE
resolver
uniprot_entry
Q3UHS6_MOUSE
resolver
uniprot_entry
Q80TM2_MOUSE
resolver
uniprot_entry
TLN1_MOUSE
resolver
uniprot_sec
A2AIM8
resolver
uniprot_sec
Q8VEF0
resolver
amino_acid_sequence
MVALSLKISIGNVVKTMQFEPSTMVYDACRMIRERIPEALAGPPNDFGLFLSDDDPKKGIWLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKDEGTGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWSLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKVEHGSVALPAIMRSGASGPENFQVGSMPPAQQQITSGQMHRGHMPPLTSAQQALTGTINSSMQAVQAAQATLDDFETLPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGNGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDVLMQLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASAPKASAGPQPLLVQSCKAVAEQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEIKAAARDGKLKPLPGETMEKCTQDLGNSTKAVSSAIAKLLGEIAQGNENYAGIAARDVAGGLRSLAQAARGVAALTSDPAVQAIVLDTASDVLDKASSLIEEAKKASGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPASPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRQLETVRELLENPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAIATASKALCGFTEAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLASARTANPTAKRQFVQSAKEVANSTANLVKTIKALDGDFTEENRAQCRAATAPLLEAVDNLSAFASNPEFSSVPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPRWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLASAARAEASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGDPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASQAKPAAVAAENEEIGAHIKHRVQELGHGCSALVTKAGALQCSPSDVYTKKELIECARRVSEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGAETFADHREGILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACKEAAFHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQKPNPDLKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEDQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYKFLPSELRDEH
uniprot
proteins
function
FUNCTION: High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000269|PubMed:27410476}.
uniprot
proteins
mass_dalton
269821
uniprot
proteins
mutagenesis
MUTAGEN 809; /note="T->I: Reduces stability and binding to VCL with little effect on binding to APBB1IP; when associated with V-833; V-867 and I-901."; /evidence="ECO:0000269|PubMed:23389036"; MUTAGEN 833; /note="T->V: Reduces stability and binding to VCL with little effect on binding to APBB1IP; when associated with I-809; V-867 and I-901."; /evidence="ECO:0000269|PubMed:23389036"; MUTAGEN 867; /note="T->V: Reduces stability and binding to VCL with little effect on binding to APBB1IP; when associated with I-809; V-833 and I-901."; /evidence="ECO:0000269|PubMed:23389036"; MUTAGEN 901; /note="T->I: Reduces stability and binding to VCL with little effect on binding to APBB1IP; when associated with I-809; V-833 and V-867."; /evidence="ECO:0000269|PubMed:23389036"; MUTAGEN 1404; /note="G->L: Does not affect focal adhesion (FA) formation, cell adhesion and spreading. Impairs the interaction with KANK1 and abrogates KANK1 association with FAs. Interferes with CMSCs clustering and causes microtubule disorganization in the vicinity of FAs."; /evidence="ECO:0000269|PubMed:27410476"; MUTAGEN 1630; /note="W->A: Impairs the interaction with KANK1."; /evidence="ECO:0000269|PubMed:27410476"; MUTAGEN 1641; /note="S->E: Does not significantly affect the interaction with KANK1."; /evidence="ECO:0000269|PubMed:27410476
uniprot
proteins
pubmed
15272303
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15623515
uniprot
proteins
pubmed
15642262
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20610383
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2120593
uniprot
proteins
pubmed
21768292
uniprot
proteins
pubmed
23389036
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
27410476
uniprot
proteins
pubmed
36792666
uniprot
proteins
pubmed
7622520
uniprot
proteins
sequence_length
2541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell surface {ECO:0000269|PubMed:21768292}. Cell junction, focal adhesion {ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:27410476}. Note=Colocalizes with LAYN at the membrane ruffles (By similarity). Localized preferentially in focal adhesions than fibrillar adhesions. {ECO:0000250}.
uniprot
proteins