Eif2s2
entrez
67204
canonical
uniprot
Q99L45
canonical
ensembl
ENSMUSG00000074656
resolver
ensp
ENSMUSP00000096777
resolver
enst
ENSMUST00000099173
resolver
genesymbol
Eif2s2
resolver
uniprot
Q3ULL5
resolver
uniprot
Q9CSH6
resolver
uniprot
Q9CT12
resolver
uniprot_entry
IF2B_MOUSE
resolver
uniprot_entry
Q3ULL5_MOUSE
resolver
uniprot_sec
Q9CSH6
resolver
uniprot_sec
Q9CT12
resolver
amino_acid_sequence
MSGDEMIFDPTMSKKKKKKKKPFMLDEEGDAQTEETQPSETKEVEPEPTEEKDVDADEEDSRKKDASDDLDDLNFFNQKKKKKKTKKIFDIDEAEEAIKDVKIESDAQEPAEPEDDLDIMLGNKKKKKKNVKFPEEDEILEKDEALEDEDSKKDDGISFSSQTAWAGSERDYTYEELLNRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAKAN
uniprot
proteins
function
FUNCTION: Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B. {ECO:0000250|UniProtKB:P05198}.
uniprot
proteins
mass_dalton
38092
uniprot
proteins
protein_family
EIF-2-beta/eIF-5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16931514
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56329}.
uniprot
proteins