MFNG
entrez
4242
canonical
uniprot
O00587
canonical
ensembl
ENSG00000100060
resolver
ensp
ENSP00000349490
resolver
ensp
ENSP00000413855
resolver
genesymbol
MFNG
resolver
hgnc
HGNC:7038
resolver
uniprot
B4DLT6
resolver
uniprot
O43730
resolver
uniprot
Q504S9
resolver
uniprot_entry
MFNG_HUMAN
resolver
uniprot_sec
B4DLT6
resolver
uniprot_sec
O43730
resolver
uniprot_sec
Q504S9
resolver
amino_acid_sequence
MQCRLPRGLAGALLTLLCMGLLCLRYHLNLSPQRVQGTPELSQPNPGPPKLQLHDVFIAVKTTRAFHRLRLELLLDTWVSRTREQTFVFTDSPDKGLQERLGSHLVVTNCSAEHSHPALSCKMAAEFDTFLASGLRWFCHVDDDNYVNPRALLQLLRAFPLARDVYVGRPSLNRPIHASEPQPHNRTRLVQFWFATGGAGFCINRKLALKMAPWASGSRFMDTSALIRLPDDCTMGYIIECKLGGRLQPSPLFHSHLETLQLLRTAQLPEQVTLSYGVFEGKLNVIKLQGPFSPEEDPSRFRSLHCLLYPDTPWCPQLGAR
uniprot
proteins
ec_number
2.4.1.222
uniprot
proteins
function
FUNCTION: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (By similarity). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). {ECO:0000250|UniProtKB:O09008}.
uniprot
proteins
mass_dalton
36202
uniprot
proteins
protein_family
Glycosyltransferase 31 family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9187150
uniprot
proteins
sequence_length
321
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..27; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins