SRBD1
entrez
55133
canonical
uniprot
Q8N5C6
canonical
ensembl
ENSG00000068784
resolver
ensp
ENSP00000263736
resolver
genesymbol
SRBD1
resolver
hgnc
HGNC:25521
resolver
uniprot
B7Z6X7
resolver
uniprot
Q53T56
resolver
uniprot
Q96TA4
resolver
uniprot
Q9NW11
resolver
uniprot_entry
B7Z6X7_HUMAN
resolver
uniprot_entry
SRBD1_HUMAN
resolver
uniprot_sec
Q53T56
resolver
uniprot_sec
Q96TA4
resolver
uniprot_sec
Q9NW11
resolver
amino_acid_sequence
MSSLPRRAKVQVQDVVLKDEFSSFSELSSASEEDDKEDSAWEPQKKVPRSRKQPPPKESKPKRMPRVKKNAPQISDGSEVVVVKEELNSSVAIADTALEDRKNKLDTVQTLKTAKTKQKCAAQPHTVRRTKKLKVEEETSKASNLEGESNSSETPSTSTVWGGTCKKEENDDDFTFGQSALKKIKTETYPQGQPVKFPANANSTKEEVEMNWDMVQVLSERTNIEPWVCANIIRLFNDDNTIPFIIRYRKELINNLDADSLREVQQTLEELRAVAKKVHSTIQKIKKEGKMSECLLKAMLNCKTFEELEHVSAPYKTGSKGTKAQRARQLGLEGAARALLEKPGELSLLSYIRPDVKGLSTLQDIEIGVQHILADMIAKDKDTLDFIRNLCQKRHVCIQSSLAKVSSKKVNEKDVDKFLLYQHFSCNIRNIHHHQILAINRGENLKVLTVKVNISDGVKDEFCRWCIQNRWRPRSFARPELMKILYNSLNDSFKRLIYPLLCREFRAKLTSDAEKESVMMFGRNLRQLLLTSPVPGRTLMGVDPGYKHGCKLAIISPTSQILHTDVVYLHCGQGFREAEKIKTLLLNFNCSTVVIGNGTACRETEAYFADLIMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMPGLDPNLRSAVSIARRVQDPLAELVKIEPKHIGVGMYQHDVSQTLLKATLDSVVEECVSFVGVDINICSEVLLRHIAGLNANRAKNIIEWREKNGPFINREQLKKVKGLGPKSFQQCAGFIRINQDYIRTFCSQQTETSGQIQGVAVTSSADVEVTNEKQGKKKSKTAVNVLLKPNPLDQTCIHPESYDIAMRFLSSIGGTLYEVGKPEMQQKINSFLEKEGMEKIAERLQTTVHTLQVIIDGLSQPESFDFRTDFDKPDFKRSIVCLEDLQIGTVLTGKVENATLFGIFVDIGVGKSGLIPIRNVTEAKLSKTKKRRSLGLGPGERVEVQVLNIDIPRSRITLDLIRVL
uniprot
proteins
function
FUNCTION: DNA- and histone-binding protein that localizes to the central axes of mitotic chromosomes (PubMed:39955279, PubMed:40106440). Promotes chromosome segregation by facilitating TOP2A recruitment to mitotic chromosomes, thereby preventing anaphase failure (PubMed:39955279). During prophase, safeguards the decatenation process to avoid the formation of difficult-to-resolve DNA structures, preventing chromosome missegregation (PubMed:40106440). Also contributes to the regulation of nucleus pulposus cell senescence (PubMed:38169523). {ECO:0000269|PubMed:38169523, ECO:0000269|PubMed:39955279, ECO:0000269|PubMed:40106440}.
uniprot
proteins
mass_dalton
111776
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
38169523
uniprot
proteins
pubmed
39955279
uniprot
proteins
pubmed
40106440
uniprot
proteins
sequence_length
995
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:38169523}. Nucleus, nucleolus {ECO:0000269|PubMed:40106440}. Cytoplasm {ECO:0000269|PubMed:38169523}. Chromosome {ECO:0000269|PubMed:39955279, ECO:0000269|PubMed:40106440}.
uniprot
proteins