Tac1
entrez
24806
canonical
uniprot
P06767
canonical
ensembl
ENSRNOG00000078101
resolver
ensembl
ENSRNOG00055001856
resolver
ensembl
ENSRNOG00060020569
resolver
ensembl
ENSRNOG00065010762
resolver
ensp
ENSRNOP00000101198
resolver
ensp
ENSRNOP00000107053
resolver
ensp
ENSRNOP00000109336
resolver
genesymbol
Tac1
resolver
genesymbol_syn
Nka
resolver
genesymbol_syn
Nkna
resolver
genesymbol_syn
Tac2
resolver
uniprot
P08856
resolver
uniprot
P08857
resolver
uniprot
P22356
resolver
uniprot
Q6LD93
resolver
uniprot_entry
TKN1_RAT
resolver
uniprot_sec
P08856
resolver
uniprot_sec
P08857
resolver
uniprot_sec
P22356
resolver
uniprot_sec
Q6LD93
resolver
amino_acid_sequence
MKILVAVAVFFLVSTQLFAEEIGANDDLNYWSDWSDSDQIKEAMPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKRHKTDSFVGLMGKRALNSVAYERSAMQNYERRRK
uniprot
proteins
function
FUNCTION: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.; FUNCTION: [Substance P]: Is a ligand for TACR1, and triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C (PubMed:1370820). Substance P binding to TACR1 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (PubMed:1370820). Is also a TACR3 agonist with low receptor affinity (By similarity). Basic secretagogue neuropeptide released from the terminals of specific sensory nerves (By similarity). Acts as a ligand for MRGPRB2 receptor in mast cells, initiating a signaling that mediates neurogenic inflammation and pain (By similarity). Neurogenic inflammation includes mast cell activation, recruitment of immune cells and release of inflammatory mediators, such as cytokines and chemokines (By similarity). The inflammatory response can then activate or sensitize nociceptors, promoting pain (By similarity). {ECO:0000250|UniProtKB:P20366, ECO:0000250|UniProtKB:P41539, ECO:0000269|PubMed:1370820}.; FUNCTION: [Neurokinin A]: Is a ligand for TACR2, and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (PubMed:1370820). Binding to TACR2 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (PubMed:1370820). {ECO:0000269|PubMed:1370820}.
uniprot
proteins
mass_dalton
15001
uniprot
proteins
post_translational_modification
PTM: [Substance P]: The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME). {ECO:0000250|UniProtKB:P20366}.
uniprot
proteins
protein_family
Tachykinin family
uniprot
proteins
pubmed
1370820
uniprot
proteins
pubmed
1695945
uniprot
proteins
pubmed
1702066
uniprot
proteins
pubmed
2429656
uniprot
proteins
pubmed
2433692
uniprot
proteins
pubmed
2809597
uniprot
proteins
pubmed
7519424
uniprot
proteins
pubmed
8448217
uniprot
proteins
sequence_length
130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.; SUBCELLULAR LOCATION: [Substance P]: Secreted {ECO:0000250|UniProtKB:P20366}.
uniprot
proteins