Nkx2-5
entrez
18091
canonical
uniprot
P42582
canonical
ensembl
ENSMUSG00000015579
resolver
ensp
ENSMUSP00000015723
resolver
ensp
ENSMUSP00000157537
resolver
enst
ENSMUST00000015723
resolver
genesymbol
Nkx2-5
resolver
genesymbol_syn
Csx
resolver
genesymbol_syn
Nkx-2.5
resolver
genesymbol_syn
Nkx2e
resolver
uniprot
P97335
resolver
uniprot
Q3UQU2
resolver
uniprot_entry
NKX25_MOUSE
resolver
uniprot_entry
Q3UQU2_MOUSE
resolver
uniprot_sec
P97335
resolver
amino_acid_sequence
MFPSPALTPTPFSVKDILNLEQQQRSLASGDLSARLEATLAPASCMLAAFKPEAYSGPEAAASGLAELRAEMGPAPSPPKCSPAFPAAPTFYPGAYGDPDPAKDPRADKKELCALQKAVELDKAETDGAERPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQDQTLELLGPPPPPARRIAVPVLVRDGKPCLGDPAAYAPAYGVGLNAYGYNAYPYPSYGGAACSPGYSCAAYPAAPPAAQPPAASANSNFVNFGVGDLNTVQSPGMPQGNSGVSTLHGIRAW
uniprot
proteins
function
FUNCTION: Transcription factor required for the development of the heart and the spleen (PubMed:16556915, PubMed:19483677, PubMed:22560297, PubMed:9584153). During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (PubMed:9584153). May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (PubMed:12023302). Binds to the core DNA motif of NPPA promoter (PubMed:19483677). Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297). Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia (By similarity). {ECO:0000250|UniProtKB:P52952, ECO:0000269|PubMed:12023302, ECO:0000269|PubMed:16556915, ECO:0000269|PubMed:19483677, ECO:0000269|PubMed:22560297, ECO:0000269|PubMed:9584153}.
uniprot
proteins
mass_dalton
34163
uniprot
proteins
protein_family
NK-2 homeobox family
uniprot
proteins
pubmed
12023302
uniprot
proteins
pubmed
14757752
uniprot
proteins
pubmed
15542826
uniprot
proteins
pubmed
16556915
uniprot
proteins
pubmed
17584735
uniprot
proteins
pubmed
19483677
uniprot
proteins
pubmed
22560297
uniprot
proteins
pubmed
7690144
uniprot
proteins
pubmed
7904557
uniprot
proteins
pubmed
7910553
uniprot
proteins
pubmed
9584153
uniprot
proteins
pubmed
9748262
uniprot
proteins
pubmed
9778505
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19483677}.
uniprot
proteins