TRIM34
entrez
53840
canonical
uniprot
Q9BYJ4
canonical
ensembl
ENSG00000258659
resolver
ensp
ENSP00000402595
resolver
ensp
ENSP00000422947
resolver
genesymbol
TRIM34
resolver
genesymbol_syn
IFP1
resolver
genesymbol_syn
RNF21
resolver
hgnc
HGNC:10063
resolver
uniprot
D3DQS7
resolver
uniprot
Q9C016
resolver
uniprot
Q9HCR0
resolver
uniprot
Q9HCR1
resolver
uniprot
Q9HCR2
resolver
uniprot_entry
TRI34_HUMAN
resolver
uniprot_sec
D3DQS7
resolver
uniprot_sec
Q9C016
resolver
uniprot_sec
Q9HCR0
resolver
uniprot_sec
Q9HCR1
resolver
uniprot_sec
Q9HCR2
resolver
amino_acid_sequence
MASKILLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSFEHLQANQHLANIVERLKEVKLSPDNGKKRDLCDHHGEKLLLFCKEDRKVICWLCERSQEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQRIQTEFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVECRSQWSTMELLQDMSGIMKWSEIWRLKKPKMVSKKLKTVFHAPDLSRMLQMFRELTAVRCYWVDVTLNSVNLNLNLVLSEDQRQVISVPIWPFQCYNYGVLGSQYFSSGKHYWEVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYGVFEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVYPYFNPWNCPAPMTLCPPSS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Functions as antiviral protein and contributes to the defense against retroviral infections (PubMed:17156811, PubMed:32282853). Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses (PubMed:32282853). During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination (PubMed:35065966). In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (PubMed:35065966). Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis (PubMed:31956709). Also promotes the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (PubMed:31487507). {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:31487507, ECO:0000269|PubMed:31956709, ECO:0000269|PubMed:32282853, ECO:0000269|PubMed:35065966}.
uniprot
proteins
mass_dalton
56864
uniprot
proteins
mutagenesis
MUTAGEN 121; /note="R->E: Reduced association with TRIM5."; /evidence="ECO:0000269|PubMed:21680743
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11013086
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
17156811
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21680743
uniprot
proteins
pubmed
31487507
uniprot
proteins
pubmed
31956709
uniprot
proteins
pubmed
32282853
uniprot
proteins
pubmed
35065966
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:31487507, ECO:0000269|PubMed:32282853}. Mitochondrion {ECO:0000269|PubMed:31956709}. Note=Localizes in cytoplasmic bodies together with TRIM5 and incoming HIV-1 capsids during infection. {ECO:0000269|PubMed:32282853}.
uniprot
proteins