ADAMTS9
entrez
56999
canonical
uniprot
Q9P2N4
canonical
ensembl
ENSG00000163638
resolver
ensp
ENSP00000295903
resolver
ensp
ENSP00000418735
resolver
genesymbol
ADAMTS9
resolver
genesymbol_syn
KIAA1312
resolver
hgnc
HGNC:13202
resolver
uniprot
A1L4L0
resolver
uniprot
B7ZVX9
resolver
uniprot
B9ZVN0
resolver
uniprot
Q9NR29
resolver
uniprot_entry
ATS9_HUMAN
resolver
uniprot_sec
A1L4L0
resolver
uniprot_sec
B7ZVX9
resolver
uniprot_sec
B9ZVN0
resolver
uniprot_sec
Q9NR29
resolver
amino_acid_sequence
MQFVSWATLLTLLVRDLAEMGSPDAAAAVRKDRLHPRQVKLLETLSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGIHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNCELPQNCKEVKRLKGASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYVTLVHGDSENFSEVYGHRLHNPTECPYNGSRRDDCQCRKDYTAAGFSSFQKIRIDLTSMQIITTDLQFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLTESARWISQGNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEVRVL
uniprot
proteins
ec_number
3.4.24.-
uniprot
proteins
function
FUNCTION: Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site) (PubMed:12514189). In addition, catalyzes the shedding of the endopeptidase MMP14 (at the '314-Tyr-|-Gly-315' site), releasing the catalytic domain from the cell surface thereby preventing the downstream pro-MMP2 activation (PubMed:37169079). Is involved in extracellular matrix proteolysis and in ciliary vesicle growth during ciliogenesis in metalloendopeptidase activity dependent manner (PubMed:30814516). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos (PubMed:22419820). {ECO:0000269|PubMed:12514189, ECO:0000269|PubMed:22419820, ECO:0000269|PubMed:30814516, ECO:0000269|PubMed:37169079}.
uniprot
proteins
mass_dalton
216491
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="R->A: No effect on mature form production."; /evidence="ECO:0000269|PubMed:12514189"; MUTAGEN 74; /note="R->A: No effect on mature form production."; /evidence="ECO:0000269|PubMed:12514189"; MUTAGEN 280; /note="R->A: No effect on mature form production."; /evidence="ECO:0000269|PubMed:12514189"; MUTAGEN 287; /note="R->A: No mature form produced."; /evidence="ECO:0000269|PubMed:12514189"; MUTAGEN 435; /note="E->A: Does not restore ciliogenesis in cells lacking ADAMST9. Highly reduces ciliogenesis. Loss of metalloendopeptise activity toward MMP14."; /evidence="ECO:0000269|PubMed:30814516, ECO:0000269|PubMed:37169079
uniprot
proteins
post_translational_modification
PTM: The precursor is cleaved by a furin endopeptidase (PubMed:12514189). The secreted form is internalized, localizing to a subpopulation of late recycling endocytic vesicles targeted to the primary cilium in a highly dynamic process necessary for ciliogenesis (PubMed:30814516). {ECO:0000269|PubMed:12514189, ECO:0000269|PubMed:30814516}.; PTM: N-glycosylated (PubMed:12514189). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). {ECO:0000250|UniProtKB:Q76LX8, ECO:0000269|PubMed:12514189}.
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
10936055
uniprot
proteins
pubmed
12514189
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
22419820
uniprot
proteins
pubmed
30814516
uniprot
proteins
pubmed
37169079
uniprot
proteins
sequence_length
1935
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12514189}. Endoplasmic reticulum {ECO:0000269|PubMed:22419820}. Cell projection, cilium {ECO:0000269|PubMed:30814516}. Recycling endosome {ECO:0000269|PubMed:30814516}. Note=Localized to the cilium base and surrounds the basal body (PubMed:30814516). The secreted form is internalized, localizing to a subpopulation of late recycling endocytic vesicles targeted to the primary cilium in a highly dynamic process necessary for ciliogenesis (PubMed:30814516). {ECO:0000269|PubMed:30814516}.
uniprot
proteins