BPIFA1
entrez
51297
canonical
uniprot
Q9NP55
canonical
ensembl
ENSG00000198183
resolver
ensp
ENSP00000346251
resolver
ensp
ENSP00000364562
resolver
ensp
ENSP00000364571
resolver
genesymbol
BPIFA1
resolver
genesymbol_syn
LUNX
resolver
genesymbol_syn
NASG
resolver
genesymbol_syn
PLUNC
resolver
genesymbol_syn
SPLUNC1
resolver
genesymbol_syn
SPURT
resolver
hgnc
HGNC:15749
resolver
uniprot
A6XMV5
resolver
uniprot
A8K9R3
resolver
uniprot
E1P5M9
resolver
uniprot
Q9NZT0
resolver
uniprot_entry
BPIA1_HUMAN
resolver
uniprot_sec
A6XMV5
resolver
uniprot_sec
A8K9R3
resolver
uniprot_sec
E1P5M9
resolver
uniprot_sec
Q9NZT0
resolver
amino_acid_sequence
MFQTGGLIVFYGLLAQTMAQFGGLPVPLDQTLPLNVNPALPLSPTGLAGSLTNALSNGLLSGGLLGILENLPLLDILKPGGGTSGGLLGGLLGKVTSVIPGLNNIIDIKVTDPQLLELGLVQSPDGHRLYVTIPLGIKLQVNTPLVGASLLRLAVKLDITAEILAVRDKQERIHLVLGDCTHSPGSLQISLLDGLGPLPIQGLLDSLTGILNKVLPELVQGNVCPLVNEVLRGLDITLVHDIVNMLIHGLQFVIKV
uniprot
proteins
function
FUNCTION: Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (PubMed:25223608). Plays a role in the innate immune responses of the upper airways (PubMed:23132494, PubMed:23499554). Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae (PubMed:23132494, PubMed:23499554, PubMed:27145151). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (PubMed:24043776, PubMed:24124190). Plays a role in the airway inflammatory response after exposure to irritants (PubMed:11425234). May attract macrophages and neutrophils (PubMed:23132494). {ECO:0000269|PubMed:11425234, ECO:0000269|PubMed:23132494, ECO:0000269|PubMed:23499554, ECO:0000269|PubMed:24043776, ECO:0000269|PubMed:24124190, ECO:0000269|PubMed:25223608, ECO:0000269|PubMed:27145151}.
uniprot
proteins
mass_dalton
26713
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="A->C: Forms an artificial disulfide bond. Negligible effect on surfactant activity; when associated with C-253."; /evidence="ECO:0000269|PubMed:27145151"; MUTAGEN 76; /note="I->C: Forms an artificial disulfide bond. Reduced surfactant activity; when associated with C-214."; /evidence="ECO:0000269|PubMed:27145151"; MUTAGEN 87..92; /note="LLGGLL->AAGGAA,SSGGSS: Impaired surfactant activity and lipopolysaccharide (LPS) binding. Reduced bacteriostatic activity."; /evidence="ECO:0000269|PubMed:27145151"; MUTAGEN 180; /note="C->A: No effect on surfactant activity; when associated with A-224."; /evidence="ECO:0000269|PubMed:27145151"; MUTAGEN 191..195; /note="LLDGL->AADGA: No effect on surfactant activity; when associated with 203-A-A-204."; /evidence="ECO:0000269|PubMed:27145151"; MUTAGEN 203..204; /note="LL->AA: No effect on surfactant activity; when associated with 191-A--A-195."; /evidence="ECO:0000269|PubMed:27145151"; MUTAGEN 214; /note="V->C: Forms an artificial disulfide bond. Reduced surfactant activity; when associated with C-76."; /evidence="ECO:0000269|PubMed:27145151"; MUTAGEN 224; /note="C->A: No effect on surfactant activity; when associated with A-180."; /evidence="ECO:0000269|PubMed:27145151"; MUTAGEN 253; /note="V->C: Forms an artificial disulfide bond. Negligible effect on surfactant activity; when associated with C-48."; /evidence="ECO:0000269|PubMed:27145151
uniprot
proteins
post_translational_modification
PTM: May be N-glycosylated. {ECO:0000269|PubMed:15158712}.
uniprot
proteins
protein_family
BPI/LBP/Plunc superfamily
uniprot
proteins
protein_family
Plunc family
uniprot
proteins
pubmed
11018263
uniprot
proteins
pubmed
11251963
uniprot
proteins
pubmed
11425234
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12409287
uniprot
proteins
pubmed
12920053
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15158712
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23132494
uniprot
proteins
pubmed
23499554
uniprot
proteins
pubmed
24043776
uniprot
proteins
pubmed
24124190
uniprot
proteins
pubmed
25223608
uniprot
proteins
pubmed
26559477
uniprot
proteins
pubmed
27145151
uniprot
proteins
sequence_length
256
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11425234, ECO:0000269|PubMed:12409287, ECO:0000269|PubMed:12920053, ECO:0000269|PubMed:15158712, ECO:0000269|PubMed:23499554, ECO:0000269|PubMed:24043776, ECO:0000269|PubMed:24124190, ECO:0000269|PubMed:26559477}. Note=Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.
uniprot
proteins