KLHDC5
entrez
57542
canonical
uniprot
Q9P2K6
canonical
ensembl
ENSG00000087448
resolver
ensp
ENSP00000370671
resolver
ensp
ENSP00000444748
resolver
ensp
ENSP00000706036
resolver
enst
ENST00000381271
resolver
enst
ENST00000539176
resolver
genesymbol
KLHDC5
resolver
genesymbol
KLHL42
resolver
genesymbol_syn
KIAA1340
resolver
genesymbol_syn
KLHDC5
resolver
hgnc
HGNC:29252
resolver
uniprot
B2RNT7
resolver
uniprot
F5H523
resolver
uniprot
Q2VPK1
resolver
uniprot
Q8N334
resolver
uniprot_entry
B2RNT7_HUMAN
resolver
uniprot_entry
F5H523_HUMAN
resolver
uniprot_entry
KLH42_HUMAN
resolver
uniprot_sec
Q2VPK1
resolver
uniprot_sec
Q8N334
resolver
amino_acid_sequence
MSAEEMVQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVLDFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQLLLSQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVSLKQRLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVTLSTSLEHRVFLKYNIFSDSWEAFRRFPAFGHNLLVSSLYLPNKAET
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis. {ECO:0000269|PubMed:19261606}.
uniprot
proteins
mass_dalton
56868
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
19261606
uniprot
proteins
sequence_length
505
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19261606}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19261606}. Note=Predominantly in mitotic cells. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase cells is localized between the two sets of separated chromosomes as well as at the spindle poles. During telophase is localized arround the nuclei of the two daughter cells. Not detected at the midbody region during cytokinesis.
uniprot
proteins