RHOU
entrez
58480
canonical
uniprot
Q7L0Q8
canonical
ensembl
ENSG00000116574
resolver
ensembl
ENSG00000284984
resolver
ensp
ENSP00000355652
resolver
genesymbol
RHOU
resolver
genesymbol_syn
ARHU
resolver
genesymbol_syn
CDC42L1
resolver
genesymbol_syn
G28K
resolver
genesymbol_syn
WRCH1
resolver
hgnc
HGNC:17794
resolver
uniprot
B1AKN1
resolver
uniprot
Q59FE9
resolver
uniprot
Q8TDQ2
resolver
uniprot_entry
RHOU_HUMAN
resolver
uniprot_sec
B1AKN1
resolver
uniprot_sec
Q59FE9
resolver
uniprot_sec
Q8TDQ2
resolver
amino_acid_sequence
MPPQQGDPAFPDRCEAPPVPPRRERGGRGGRGPGEPGGRGRAGGAEGRGVKCVLVGDGAVGKTSLVVSYTTNGYPTEYIPTAFDNFSAVVSVDGRPVRLQLCDTAGQDEFDKLRPLCYTNTDIFLLCFSVVSPSSFQNVSEKWVPEIRCHCPKAPIILVGTQSDLREDVKVLIELDKCKEKPVPEEAAKLCAEEIKAASYIECSALTQKNLKEVFDAAIVAGIQYSDTQQQPKKSKSRTPDKMKNLSKSWWKKYCCFV
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Binds to and activates protein kinase PAK1 (PubMed:11459829). Plays a role in the regulation of cell morphology, cytoskeletal organization and focal adhesion assembly during cell migration (PubMed:11459829, PubMed:17620058, PubMed:18086875, PubMed:21834987). Also stimulates quiescent cells to reenter the cell cycle (PubMed:11459829). Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound (PubMed:16472646). {ECO:0000269|PubMed:11459829, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:21834987}.
uniprot
proteins
mass_dalton
28218
uniprot
proteins
mutagenesis
MUTAGEN 63; /note="T->N: Loss of GTP-binding and localization to focal adhesions. No effect on ARHGAP30-binding."; /evidence="ECO:0000269|PubMed:11459829, ECO:0000269|PubMed:17620058, ECO:0000269|PubMed:21565175"; MUTAGEN 80; /note="P->G: No effect on ARHGAP30-binding."; /evidence="ECO:0000269|PubMed:21565175"; MUTAGEN 81; /note="T->S: Loss of binding to PAK3; when associated with A-83 and C-86."; /evidence="ECO:0000269|PubMed:17620058"; MUTAGEN 83; /note="F->A: Loss of binding to PAK3; when associated with S-81 and C-86."; /evidence="ECO:0000269|PubMed:17620058, ECO:0000269|PubMed:21565175"; MUTAGEN 83; /note="F->G: Loss of ARHGAP30-binding."; /evidence="ECO:0000269|PubMed:17620058, ECO:0000269|PubMed:21565175"; MUTAGEN 86; /note="F->C: Loss of PAK3-binding; when associated with S-81 and A-83. No effect on ARHGAP30-binding."; /evidence="ECO:0000269|PubMed:17620058, ECO:0000269|PubMed:21565175"; MUTAGEN 107; /note="Q->L: Constitutively active. Results in increased rates of stress fiber dissolution and cell migration. No effect on ARHGAP30-binding."; /evidence="ECO:0000269|PubMed:11459829, ECO:0000269|PubMed:17620058, ECO:0000269|PubMed:21565175"; MUTAGEN 177; /note="K->R: Decreased ubiquitination."; /evidence="ECO:0000269|PubMed:26598620"; MUTAGEN 248; /note="K->R: Decreased ubiquitination."; /evidence="ECO:0000269|PubMed:26598620"; MUTAGEN 255; /note="C->S: No effect on subcellular location."; /evidence="ECO:0000269|PubMed:16046391"; MUTAGEN 256; /note="C->S: Loss of subcellular location to plasma and intracellular membranes."; /evidence="ECO:0000269|PubMed:16046391
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. 'Lys-48'-linked ubiquitination at Lys-177 and Lys-248 by the ECS(RAB40A) complex leading to its degradation. {ECO:0000269|PubMed:26598620}.; PTM: Tyrosine phosphorylated by SRC in response to PTK2B/PYK2 activation. {ECO:0000269|PubMed:18086875}.
uniprot
proteins
protein_family
Rho family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11459829
uniprot
proteins
pubmed
11894124
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14731133
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16046391
uniprot
proteins
pubmed
16472646
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16751668
uniprot
proteins
pubmed
17620058
uniprot
proteins
pubmed
18086875
uniprot
proteins
pubmed
21565175
uniprot
proteins
pubmed
21834987
uniprot
proteins
pubmed
26598620
uniprot
proteins
sequence_length
258
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}; Lipid-anchor {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}; Cytoplasmic side {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}. Golgi apparatus membrane {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}; Lipid-anchor {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}. Cell junction, focal adhesion {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058, ECO:0000269|PubMed:26598620}. Cell projection, podosome {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}. Note=Localizes to podosomes in SRC-transformed cells. {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}.
uniprot
proteins