Arpp19
entrez
60336
canonical
uniprot
Q712U5
canonical
ensembl
ENSRNOG00000023086
resolver
ensembl
ENSRNOG00000063103
resolver
ensp
ENSRNOP00000087184
resolver
ensp
ENSRNOP00000109754
resolver
enst
ENSRNOT00000098678
resolver
genesymbol
Arpp19
resolver
uniprot
A0A8I6A6T3
resolver
uniprot_entry
A0A8I6A6T3_RAT
resolver
uniprot_entry
ARP19_RAT
resolver
amino_acid_sequence
MSAEVPEAASAEEQKEMEDKVTSPEKAEEAKLKARYPHLGQKPGGSDFLRKRLQKGQKYFDSGDYNMAKAKMKNKQLPAAAPDKTEVTGDHIPTPQDLPQRKPSLVASKLAG
uniprot
proteins
function
FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis (By similarity). Inhibition of PP2A is enhanced when ARPP19 is phosphorylated (By similarity). When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). May indirectly enhance GAP43 expression by binding to the NGF-regulatory region of its mRNA (PubMed:12221279). {ECO:0000250|UniProtKB:P56211, ECO:0000269|PubMed:12221279}.
uniprot
proteins
mass_dalton
12293
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-62 by MASTL/GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated at Ser-104 by PKA (By similarity). Phosphorylated at Ser-62 by MAST3 (By similarity). Phosphorylation by PKA and MAST3 is mutually antagonistic, with each kinase inhibiting phosphorylation by the other (By similarity). {ECO:0000250|UniProtKB:P56211, ECO:0000250|UniProtKB:Q6DEB4, ECO:0000269|PubMed:11279279}.
uniprot
proteins
protein_family
Endosulfine family
uniprot
proteins
pubmed
11279279
uniprot
proteins
pubmed
12221279
uniprot
proteins
pubmed
12944371
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2158525
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
112
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12944371, ECO:0000269|PubMed:2158525}.
uniprot
proteins