IL22RA1
entrez
58985
canonical
uniprot
Q8N6P7
canonical
ensembl
ENSG00000142677
resolver
ensp
ENSP00000270800
resolver
enst
ENST00000270800
resolver
genesymbol
IL22RA1
resolver
genesymbol_syn
IL22R
resolver
hgnc
HGNC:13700
resolver
uniprot
A8K839
resolver
uniprot
B2R9Y9
resolver
uniprot
Q9HB22
resolver
uniprot_entry
I22R1_HUMAN
resolver
uniprot_sec
A8K839
resolver
uniprot_sec
B2R9Y9
resolver
uniprot_sec
Q9HB22
resolver
amino_acid_sequence
MRTLLTILTVGSLAAHAPEDPSDLLQHVKFQSSNFENILTWDSGPEGTPDTVYSIEYKTYGERDWVAKKGCQRITRKSCNLTVETGNLTELYYARVTAVSAGGRSATKMTDRFSSLQHTTLKPPDVTCISKVRSIQMIVHPTPTPIRAGDGHRLTLEDIFHDLFYHLELQVNRTYQMHLGGKQREYEFFGLTPDTEFLGTIMICVPTWAKESAPYMCRVKTLPDRTWTYSFSGAFLFSMGFLVAVLCYLSYRYVTKPPAPPNSLNVQRVLTFQPLRFIQEHVLIPVFDLSGPSSLAQPVQYSQIRVSGPREPAGAPQRHSLSEITYLGQPDISILQPSNVPPPQILSPLSYAPNAAPEVGPPSYAPQVTPEAQFPFYAPQAISKVQPSSYAPQATPDSWPPSYGVCMEGSGKDSPTGTLSSPKHLRPKGQLQKEPPAGSCMLGGLSLQEVTSLAMEESQEAKSLHQPLGICTDRTSDPNVLHSGEEGTPQYLKGQLPLLSSVQIEGHPMSLPLQPPSRPCSPSDQGPSPWGLLESLVCPKDEAKSPAPETSDLEQPTELDSLFRGLALTVQWES
uniprot
proteins
function
FUNCTION: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. {ECO:0000269|PubMed:11035029, ECO:0000269|PubMed:11564763, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:12351624, ECO:0000269|PubMed:12941841, ECO:0000269|PubMed:17204547}.
uniprot
proteins
mass_dalton
63077
uniprot
proteins
mutagenesis
MUTAGEN 58; /note="K->A: Strongly reduced response to IL22."; /evidence="ECO:0000269|PubMed:18675809"; MUTAGEN 60; /note="Y->A,R: Loss of response to IL22."; /evidence="ECO:0000269|PubMed:18675809
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. {ECO:0000269|PubMed:26171402}.
uniprot
proteins
protein_family
Type II cytokine receptor family
uniprot
proteins
pubmed
10875937
uniprot
proteins
pubmed
11035029
uniprot
proteins
pubmed
11564763
uniprot
proteins
pubmed
11706020
uniprot
proteins
pubmed
12351624
uniprot
proteins
pubmed
12407026
uniprot
proteins
pubmed
12941841
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15120653
uniprot
proteins
pubmed
15308104
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17204547
uniprot
proteins
pubmed
17828272
uniprot
proteins
pubmed
17900301
uniprot
proteins
pubmed
17906500
uniprot
proteins
pubmed
18061474
uniprot
proteins
pubmed
18675809
uniprot
proteins
pubmed
26171402
uniprot
proteins
sequence_length
574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:12351624}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 229..249; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins