Ptprc
entrez
19264
canonical
uniprot
P06800
canonical
ensembl
ENSMUSG00000026395
resolver
ensp
ENSMUSP00000138275
resolver
ensp
ENSMUSP00000138350
resolver
ensp
ENSMUSP00000138800
resolver
enst
ENSMUST00000182755
resolver
genesymbol
Ptprc
resolver
genesymbol_syn
Ly-5
resolver
uniprot
E9QLT5
resolver
uniprot
Q61812
resolver
uniprot
Q61813
resolver
uniprot
Q61814
resolver
uniprot
Q61815
resolver
uniprot
Q78EF1
resolver
uniprot
Q8C6Q7
resolver
uniprot
S4R1M0
resolver
uniprot
S4R1S4
resolver
uniprot
S4R2V1
resolver
uniprot_entry
PTPRC_MOUSE
resolver
uniprot_entry
Q8C6Q7_MOUSE
resolver
uniprot_entry
S4R1M0_MOUSE
resolver
uniprot_sec
E9QLT5
resolver
uniprot_sec
Q61812
resolver
uniprot_sec
Q61813
resolver
uniprot_sec
Q61814
resolver
uniprot_sec
Q61815
resolver
uniprot_sec
Q78EF1
resolver
uniprot_sec
S4R1S4
resolver
uniprot_sec
S4R2V1
resolver
amino_acid_sequence
MTMGLWLKLLAFGFALLDTEVFVTGQTPTPSDELSTTENALLLPQSDPLPARTTESTPPSISERGNGSSETTYHPGVLSTLLPHLSPQPDSQTPSAGGADTQTFSSQADNPTLTPAPGGGTDPPGVPGERTVPGTIPADTAFPVDTPSLARNSSAASPTHTSNVSTTDISSGASLTTLTPSTLGLASTDPPSTTIATTTKQTCAAMFGNITVNYTYESSNQTFKADLKDVQNAKCGNEDCENVLNNLEECSQIKNISVSNDSCAPATTIDLYVPPGTDKFSLHDCTPKEKANTSICLEWKTKNLDFRKCNSDNISYVLHCEPENNTKCIRRNTFIPERCQLDNLRAQTNYTCVAEILYRGVKLVKNVINVQTDLGIPETPKPSCGDPAARKTLVSWPEPVSKPESASKPHGYVLCYKNNSEKCKSLPNNVTSFEVESLKPYKYYEVSLLAYVNGKIQRNGTAEKCNFHTKADRPDKVNGMKTSRPTDNSINVTCGPPYETNGPKTFYILVVRSGGSFVTKYNKTNCQFYVDNLYYSTDYEFLVSFHNGVYEGDSVIRNESTNFNAKALIIFLVFLIIVTSIALLVVLYKIYDLRKKRSSNLDEQQELVERDDEKQLMDVEPIHSDILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKDARKPHNQNKNRYVDILPYDYNRVELSEINGDAGSTYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFKDIVVTINDHKRCPDYIIQKLNVAHKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAEGKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHSCLHNMKKRDPPSDPSPLEAEYQRLPSYRSWRTQHIGNQEENKKKNRNSNVVPYDFNRVPLKHELEMSKESEPESDESSDDDSDSEETSKYINASFVMSYWKPEMMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELVNGDQEVCAQYWGEGKQTYGDMEVEMKDTNRASAYTLRTFELRHSKRKEPRTVYQYQCTTWKGEELPAEPKDLVSMIQDLKQKLPKASPEGMKYHKHASILVHCRDGSQQTGLFCALFNLLESAETEDVVDVFQVVKSLRKARPGVVCSYEQYQFLYDIIASIYPAQNGQVKKTNSQDKIEFHNEVDGGKQDANCVRPDGPLNKAQEDSRGVGTPEPTNSAEEPEHAANGSASPAPTQSS
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity. {ECO:0000250, ECO:0000250|UniProtKB:P08575, ECO:0000269|PubMed:10415030}.
uniprot
proteins
mass_dalton
144837
uniprot
proteins
post_translational_modification
PTM: Heavily N- and O-glycosylated.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 1/6 subfamily
uniprot
proteins
pubmed
10415030
uniprot
proteins
pubmed
1822988
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
1932742
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2522930
uniprot
proteins
pubmed
2944116
uniprot
proteins
pubmed
2948186
uniprot
proteins
pubmed
3037546
uniprot
proteins
pubmed
3211131
uniprot
proteins
pubmed
3417340
uniprot
proteins
pubmed
3570377
uniprot
proteins
pubmed
3864163
uniprot
proteins
pubmed
9148925
uniprot
proteins
sequence_length
1293
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08575}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000250|UniProtKB:P08575}. Synapse {ECO:0000250|UniProtKB:P08575}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000250|UniProtKB:P08575}.
uniprot
proteins
transmembrane_region
TRANSMEM 567..588; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins