CENPB
entrez
1059
canonical
uniprot
P07199
canonical
ensembl
ENSG00000125817
resolver
ensp
ENSP00000369075
resolver
enst
ENST00000379751
resolver
genesymbol
CENPB
resolver
hgnc
HGNC:1852
resolver
uniprot
Q96EI4
resolver
uniprot_entry
CENPB_HUMAN
resolver
uniprot_sec
Q96EI4
resolver
amino_acid_sequence
MGPKRRQLTFREKSRIIQEVEENPDLRKGEIARRFNIPPSTLSTILKNKRAILASERKYGVASTCRKTNKLSPYDKLEGLLIAWFQQIRAAGLPVKGIILKEKALRIAEELGMDDFTASNGWLDRFRRRHGVVSCSGVARARARNAAPRTPAAPASPAAVPSEGSGGSTTGWRAREEQPPSVAEGYASQDVFSATETSLWYDFLPDQAAGLCGGDGRPRQATQRLSVLLCANADGSEKLPPLVAGKSAKPRAGQAGLPCDYTANSKGGVTTQALAKYLKALDTRMAAESRRVLLLAGRLAAQSLDTSGLRHVQLAFFPPGTVHPLERGVVQQVKGHYRQAMLLKAMAALEGQDPSGLQLGLTEALHFVAAAWQAVEPSDIAACFREAGFGGGPNATITTSLKSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEEEEDEESSSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSDSEEEDDEEEDDEDEDDDDDEEDGDEVPVPSFGEAMAYFAMVKRYLTSFPIDDRVQSHILHLEHDLVHVTRKNHARQAGVRGLGHQS
uniprot
proteins
function
FUNCTION: Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box (PubMed:11726497). May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable). {ECO:0000269|PubMed:11726497, ECO:0000305}.
uniprot
proteins
mass_dalton
65171
uniprot
proteins
mutagenesis
MUTAGEN 4; /note="K->Q: Abolishes N-terminal methylation."; /evidence="ECO:0000269|PubMed:23978223
uniprot
proteins
post_translational_modification
PTM: Poly-ADP-ribosylated by PARP1. {ECO:0000250|UniProtKB:P27790}.; PTM: N-terminally methylated by METTL11A/NTM1. Alpha-N-methylation is stimulated in response to extracellular stimuli, including increased cell density and heat shock, and seems to facilitate binding to CENP-B boxes. Chromatin-bound CENP-B is primarily trimethylated. {ECO:0000269|PubMed:23978223}.
uniprot
proteins
pubmed
11726497
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14522975
uniprot
proteins
pubmed
1469042
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18072184
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
1893793
uniprot
proteins
pubmed
19412974
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23978223
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2435739
uniprot
proteins
pubmed
24522885
uniprot
proteins
pubmed
27499292
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
9451007
uniprot
proteins
sequence_length
599
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320, ECO:0000255|PROSITE-ProRule:PRU00583, ECO:0000269|PubMed:18072184}. Chromosome, centromere {ECO:0000269|PubMed:18072184}.
uniprot
proteins