SIRPA
entrez
140885
canonical
uniprot
P78324
canonical
ensembl
ENSG00000198053
resolver
ensp
ENSP00000348307
resolver
ensp
ENSP00000351621
resolver
ensp
ENSP00000382941
resolver
ensp
ENSP00000478763
resolver
ensp
ENSP00000559503
resolver
ensp
ENSP00000559506
resolver
ensp
ENSP00000559511
resolver
ensp
ENSP00000559515
resolver
ensp
ENSP00000559528
resolver
ensp
ENSP00000583981
resolver
ensp
ENSP00000634352
resolver
genesymbol
SIRPA
resolver
genesymbol_syn
BIT
resolver
genesymbol_syn
MFR
resolver
genesymbol_syn
MYD1
resolver
genesymbol_syn
PTPNS1
resolver
genesymbol_syn
SHPS1
resolver
genesymbol_syn
SIRP
resolver
hgnc
HGNC:9662
resolver
uniprot
A2A2E1
resolver
uniprot
A8K411
resolver
uniprot
B2R6C3
resolver
uniprot
O00683
resolver
uniprot
O43799
resolver
uniprot
Q8N517
resolver
uniprot
Q8TAL8
resolver
uniprot
Q9H0Z2
resolver
uniprot
Q9UDX2
resolver
uniprot
Q9UIJ6
resolver
uniprot
Q9Y4U9
resolver
uniprot_entry
SHPS1_HUMAN
resolver
uniprot_sec
A2A2E1
resolver
uniprot_sec
A8K411
resolver
uniprot_sec
B2R6C3
resolver
uniprot_sec
O00683
resolver
uniprot_sec
O43799
resolver
uniprot_sec
Q8N517
resolver
uniprot_sec
Q8TAL8
resolver
uniprot_sec
Q9H0Z2
resolver
uniprot_sec
Q9UDX2
resolver
uniprot_sec
Q9UIJ6
resolver
uniprot_sec
Q9Y4U9
resolver
amino_acid_sequence
MEPAGPAPGRLGPLLCLLLAASCAWSGVAGEEELQVIQPDKSVLVAAGETATLRCTATSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRIGNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAARATPQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHSTAKVVLTREDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVRKFYPQRLQLTWLENGNVSRTETASTVTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVSAHPKEQGSNTAAENTGSNERNIYIVVGVVCTLLVALLMAALYLVRIRQKKAQGSTSSTRLHEPEKNAREITQDTNDITYADLNLPKGKKPAPQAAEPNNHTEYASIQTSPQPASEDTLTYADLDMVHLNRTPKQPAPKPEPSFSEYASVQVPRK
uniprot
proteins
function
FUNCTION: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (By similarity). Receptor for THBS1 (PubMed:24511121). Interaction with THBS1 stimulates phosphorylation of SIRPA (By similarity). In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production (PubMed:24511121). {ECO:0000250, ECO:0000250|UniProtKB:P97710, ECO:0000269|PubMed:10469599, ECO:0000269|PubMed:11509594, ECO:0000269|PubMed:24511121}.
uniprot
proteins
mass_dalton
54967
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:9062191}.; PTM: Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11. {ECO:0000269|PubMed:10842184, ECO:0000269|PubMed:9062191}.
uniprot
proteins
pubmed
10469599
uniprot
proteins
pubmed
10585853
uniprot
proteins
pubmed
10842184
uniprot
proteins
pubmed
11509594
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
17369261
uniprot
proteins
pubmed
18657508
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24511121
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9062191
uniprot
proteins
pubmed
9070220
uniprot
proteins
pubmed
9485180
uniprot
proteins
sequence_length
504
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 374..394; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins