Tifa
entrez
211550
canonical
uniprot
Q793I8
canonical
ensembl
ENSMUSG00000046688
resolver
ensp
ENSMUSP00000054036
resolver
ensp
ENSMUSP00000126692
resolver
ensp
ENSMUSP00000127700
resolver
ensp
ENSMUSP00000132309
resolver
ensp
ENSMUSP00000299598
resolver
ensp
ENSMUSP00000299601
resolver
enst
ENSMUST00000054483
resolver
enst
ENSMUST00000163775
resolver
enst
ENSMUST00000164447
resolver
enst
ENSMUST00000171621
resolver
genesymbol
Tifa
resolver
genesymbol_syn
T2bp
resolver
uniprot
I3PQW8
resolver
uniprot
Q3TLY9
resolver
uniprot_entry
I3PQW8_MOUSE
resolver
uniprot_entry
TIFA_MOUSE
resolver
uniprot_sec
Q3TLY9
resolver
amino_acid_sequence
MSTFEDADTEETVTCLQMTIYHPGQQSGIFKSIRFCSKEKFPSIEVVKFGRNSNMCQYTFQDKQVSRIQFVLQPFKQFNSSVLSFEIKNMSKKTSLMVDNQELGYLNKMDLPYKCMLRFGEYQFLLQKEDGESVESFETQFIMSSRPLLQENNWPTQNPIPEDGMYSSYFTHRSSPSEMDENEL
uniprot
proteins
function
FUNCTION: Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs) (PubMed:11798190). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (By similarity). TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of pro-inflammatory NF-kappa-B signaling (By similarity). {ECO:0000250|UniProtKB:Q96CG3, ECO:0000269|PubMed:11798190}.
uniprot
proteins
mass_dalton
21560
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-9 following detection of ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose) by ALPK1. Phosphorylation at Thr-9 by ALPK1 leads to the formation of an intermolecular binding between the FHA domain and phosphorylated Thr-9, promoting TIFA oligomerization and TIFA-mediated NF-kappa-B activation. {ECO:0000250|UniProtKB:Q96CG3}.
uniprot
proteins
protein_family
TIFA family
uniprot
proteins
pubmed
11798190
uniprot
proteins
pubmed
12566447
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96CG3}. Note=Colocalizes with lysosomal marker LAMP2 following homooligomerization and subsequent activation. {ECO:0000250|UniProtKB:Q96CG3}.
uniprot
proteins