Hic1
entrez
15248
canonical
uniprot
Q9R1Y5
canonical
ensembl
ENSMUSG00000043099
resolver
ensp
ENSMUSP00000053483
resolver
ensp
ENSMUSP00000170070
resolver
ensp
ENSMUSP00001091661
resolver
enst
ENSMUST00000055619
resolver
enst
ENSMUST00000131720
resolver
genesymbol
Hic1
resolver
uniprot
B1ARH0
resolver
uniprot
Q9R1Y6
resolver
uniprot
Q9R2B0
resolver
uniprot
Z4YJP0
resolver
uniprot_entry
HIC1_MOUSE
resolver
uniprot_entry
Z4YJP0_MOUSE
resolver
uniprot_sec
B1ARH0
resolver
uniprot_sec
Q9R1Y6
resolver
uniprot_sec
Q9R2B0
resolver
amino_acid_sequence
MTFPEADILLKSGECAGQTMLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLTDSVEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGSGGGGYAPYGRPGRGLRAATPVIQACYSSPAGPPPPPAAEPPSGPDAAVNTHCAELYASGPGPAASLCAPERRCSPLCGLDLSKKSPPGSSVPERPLSERELPPRPDSPPGAGPAVYKEPSLALPPLPPLPFQKLEEAVPTPDPFRGSGGSPGPEPPGRPDGSSLLYRWMKHEPGLGSYGDELVRDRGSPGERLEERGGDPAASPGGPPLGLVPPPRYPGSLDGPGTGADGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVTGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDSRTIDRFSPT
uniprot
proteins
function
FUNCTION: Transcriptional repressor (PubMed:18347096). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (By similarity). May act as a tumor suppressor (PubMed:16269335, PubMed:18347096). Involved in development of head, face, limbs and ventral body wall (PubMed:10655551). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (By similarity). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (By similarity). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (By similarity). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (By similarity). Probably represses transcription from ACKR3, FGFBP1 and EFNA1 (By similarity). {ECO:0000250|UniProtKB:Q14526, ECO:0000269|PubMed:10655551, ECO:0000269|PubMed:16269335, ECO:0000269|PubMed:18347096}.
uniprot
proteins
mass_dalton
76828
uniprot
proteins
post_translational_modification
PTM: Acetylated on several residues, including Lys-333. Lys-333 is deacetylated by SIRT1 (By similarity). {ECO:0000250}.; PTM: Sumoylated on Lys-333 by a PIAS family member, which enhances interaction with MTA1, positively regulates transcriptional repression activity and is enhanced by HDAC4. {ECO:0000250}.
uniprot
proteins
protein_family
Hic subfamily
uniprot
proteins
protein_family
Krueppel C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
10072440
uniprot
proteins
pubmed
10371200
uniprot
proteins
pubmed
10655551
uniprot
proteins
pubmed
11073960
uniprot
proteins
pubmed
12539045
uniprot
proteins
pubmed
16269335
uniprot
proteins
pubmed
18347096
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
733
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins