Dolk
entrez
227697
canonical
uniprot
Q8R2Y3
canonical
ensembl
ENSMUSG00000075419
resolver
ensp
ENSMUSP00000097792
resolver
enst
ENSMUST00000100219
resolver
genesymbol
Dolk
resolver
genesymbol_syn
Tmem15
resolver
uniprot_entry
DOLK_MOUSE
resolver
amino_acid_sequence
MTRQCPPQESGAALSGSVLAEAAVVFAVVLSIHAAVWDRYSWCAVALAVQAFYVQYKWDRLLQQGNAVFQFRMSANSGLLPASMVMPLLGLVMKERCQTAGNPYFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCAISGLAGGVIIYIMRHSLSVGEVIEVLEVLLIFVYLNMILLYLLPRCFTPGEALLVLGGISFVLNQLIKRSLTESQGDPVDFFLLVVVVGMVLMGVFFSTLFVFMDSGTWASSIFFHLMTCVLGLGVVLPWLHWLIRRNPLLWLLQFLFYTETRIYLLAYWSLLASVACLVVLYQNAKRSSSESKKHRAPTITRKYFHFIVVATYIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSLLSLFLDERDSGPLILTHIYLLLGMSLPIWLIPRPCTQKDSLEGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA
uniprot
proteins
ec_number
2.7.1.108
uniprot
proteins
function
FUNCTION: Catalyzes CTP-mediated phosphorylation of dolichol, the terminal step in de novo dolichyl monophosphate (Dol-P) biosynthesis. Dol-P is a lipid carrier essential for the synthesis of N-linked and O-linked oligosaccharides and for GPI anchors. {ECO:0000250|UniProtKB:Q9UPQ8}.
uniprot
proteins
mass_dalton
59145
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q9UPQ8}.
uniprot
proteins
protein_family
Polyprenol kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
534
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UPQ8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UPQ8}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 73..93; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 133..153; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 162..182; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 187..207; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 221..241; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 253..273; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 294..314; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 334..350; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 356..376; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 398..418; /note="Helical; Name=12"; /evidence="ECO:0000255"; TRANSMEM 433..453; /note="Helical; Name=13"; /evidence="ECO:0000255"; TRANSMEM 469..489; /note="Helical; Name=14"; /evidence="ECO:0000255"; TRANSMEM 492..512; /note="Helical; Name=15"; /evidence="ECO:0000255
uniprot
proteins