Dctn4
entrez
67665
canonical
uniprot
Q8CBY8
canonical
ensembl
ENSMUSG00000024603
resolver
ensp
ENSMUSP00000025505
resolver
ensp
ENSMUSP00000153008
resolver
genesymbol
Dctn4
resolver
uniprot
Q3TQY2
resolver
uniprot
Q923A0
resolver
uniprot
Q9D4X0
resolver
uniprot_entry
DCTN4_MOUSE
resolver
uniprot_entry
Q3TQY2_MOUSE
resolver
uniprot_sec
Q923A0
resolver
uniprot_sec
Q9D4X0
resolver
amino_acid_sequence
MASLLQSERVLYLVQGEKKVRAPLSQLYFCRYCSELRSLECVSHEVDSHYCPSCLENMPSAEAKLKKNRCANCFDCPGCMHTLSTRATSISTQLPDDPAKTTMKKAYYLACGFCRWTSRDVGMADKSVASGGWQEPENPHTQRMNKLIEYYQQLAQKEKVERDRKKLARRRNYMPLAFSQHTIHVVDKYSLGTRLQRPRAGASISTLAGLSLREGEDQKEVKIEPAQAVAEVEPLPEDYYTRPVNLTEVTTLQQRLLQPDLQPVSASQLYPRHKHLLIKRSLRCRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLLECDEGDPDNINSTAKVVVPPKELILAGKDAAAEYDELAEPQDFQDDPDIVAFRKANKVGIFIKVTPQREEGEVTVCFKMKHDFKNLAAPIRPVEEGDQGTEVIWLTQHVELSFGPLLP
uniprot
proteins
function
FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:A0A4X1TB62}.
uniprot
proteins
mass_dalton
53057
uniprot
proteins
protein_family
Dynactin subunit 4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19109891
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34197691
uniprot
proteins
sequence_length
467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9UJW0}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9UJW0}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q9QUR2}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9QUR2}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:19109891}. Note=Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin (By similarity). Overexpression in cultured mammalian cells revealed colocalization with cortical actin, stress fibers, and focal adhesion sites, sites of potential interaction between microtubules and the cell cortex (By similarity). In skeletal muscles, costamere localization requires the presence of ANK2 (PubMed:19109891). {ECO:0000250|UniProtKB:Q9QUR2, ECO:0000250|UniProtKB:Q9UJW0, ECO:0000269|PubMed:19109891}.
uniprot
proteins