Dpm2
entrez
29640
canonical
uniprot
Q9Z325
canonical
ensembl
ENSRNOG00000084654
resolver
ensp
ENSRNOP00000104528
resolver
enst
ENSRNOT00000131121
resolver
genesymbol
Dpm2
resolver
uniprot_entry
DPM2_RAT
resolver
amino_acid_sequence
MATGTDQAVGFGLVAVSLIIFTYYTTWVILLPFIDSQHVIHKYFLPRAYAVLLPLAAGLLLLLFVGLFITYVLLKSQKVTKKAQ
uniprot
proteins
function
FUNCTION: Regulates the biosynthesis of dolichol phosphate-mannose (PubMed:9724629). Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1 (PubMed:9724629). Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the GPI-GNT complex (By similarity). {ECO:0000250|UniProtKB:O94777, ECO:0000269|PubMed:9724629}.
uniprot
proteins
mass_dalton
9344
uniprot
proteins
mutagenesis
MUTAGEN 21; /note="F->L: Abolishes interaction with DPM1; when associated with S-23."; /evidence="ECO:0000269|PubMed:9724629"; MUTAGEN 23; /note="Y->S: Abolishes interaction with DPM1; when associated with L-21."; /evidence="ECO:0000269|PubMed:9724629
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:9724629}.
uniprot
proteins
protein_family
DPM2 family
uniprot
proteins
pubmed
9724629
uniprot
proteins
sequence_length
84
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9724629}; Multi-pass membrane protein {ECO:0000269|PubMed:9724629}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins