Fchsd2
entrez
207278
canonical
uniprot
Q3USJ8
canonical
ensembl
ENSMUSG00000030691
resolver
ensp
ENSMUSP00000032931
resolver
ensp
ENSMUSP00000095850
resolver
ensp
ENSMUSP00000251298
resolver
genesymbol
Fchsd2
resolver
genesymbol_syn
Kiaa0769
resolver
genesymbol_syn
Sh3md3
resolver
uniprot
Q3UQZ2
resolver
uniprot
Q6P9R0
resolver
uniprot
Q80TS2
resolver
uniprot_entry
FCSD2_MOUSE
resolver
uniprot_sec
Q3UQZ2
resolver
uniprot_sec
Q6P9R0
resolver
uniprot_sec
Q80TS2
resolver
amino_acid_sequence
MQPPPRKVKVTQELRNIQGEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGIQKLASQYLKRDWPGIKTDDRNDYRSMYPVWKSFLEGTMQVAQSRINICENYKNFISEPARAVRSLKEQQLKRCVDQLTKIQTELQETVKDLVKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNTKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAIQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNELECHGVALSEQSRAELEQKIDEARESIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPPAVTSNGTLHSLNADAEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFSGRIGVFPSVLVEELSASENGDTPWTREIQISPSPKPHTSLPPLPLYDQPPSSPYPSPDKRSSQFFPRSPSANENSLHAESPGFSQASRQTPDTSYGKLRPVRAAPPPPTQNHRRTTEKMEDVEITLV
uniprot
proteins
function
FUNCTION: Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling. Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (By similarity). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex (PubMed:23437151). Does not promote actin polymerization in the absence of membranes (By similarity). {ECO:0000250|UniProtKB:O94868, ECO:0000305|PubMed:23437151}.
uniprot
proteins
mass_dalton
84282
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation on a Ser residue is important for recruitment to the cell membrane and for its role in promoting endocytosis. {ECO:0000250|UniProtKB:O94868}.
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15067381
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23437151
uniprot
proteins
pubmed
23761074
uniprot
proteins
pubmed
26567222
uniprot
proteins
pubmed
26686642
uniprot
proteins
pubmed
29887380
uniprot
proteins
sequence_length
740
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:23437151}. Cell junction {ECO:0000250|UniProtKB:O94868}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:O94868}. Cell membrane {ECO:0000250|UniProtKB:O94868}; Peripheral membrane protein {ECO:0000250|UniProtKB:O94868}; Cytoplasmic side {ECO:0000250|UniProtKB:O94868}. Cell projection, stereocilium {ECO:0000269|PubMed:23437151}. Note=Partially localized at clathrin-coated pits at the cell membrane. Detected at the cell membrane at sites around clathrin-coated pits, very close to the clathrin-coated pits but not an intrinsic part of the clathrin-coated pits. Colocalizes at cell-cell contacts with CDH1, but is not detected at tight junctions. {ECO:0000250|UniProtKB:O94868}.
uniprot
proteins