Phactr4
entrez
100169
canonical
uniprot
Q501J7
canonical
ensembl
ENSMUSG00000066043
resolver
ensp
ENSMUSP00000081185
resolver
ensp
ENSMUSP00000081270
resolver
ensp
ENSMUSP00000099628
resolver
genesymbol
Phactr4
resolver
genesymbol_syn
Kiaa4120
resolver
uniprot
A2ALF7
resolver
uniprot
A2ALG0
resolver
uniprot
F6QNZ3
resolver
uniprot
Q5DTM4
resolver
uniprot
Q6DI97
resolver
uniprot
Q8C7U9
resolver
uniprot_entry
PHAR4_MOUSE
resolver
uniprot_sec
A2ALF7
resolver
uniprot_sec
A2ALG0
resolver
uniprot_sec
F6QNZ3
resolver
uniprot_sec
Q5DTM4
resolver
uniprot_sec
Q6DI97
resolver
uniprot_sec
Q8C7U9
resolver
amino_acid_sequence
MEDPSEEAEQPSGDPGMGMDSVEAGDTTPPTKRKSKFSALGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELVKRGVLLEDPEQDGEDSGKLSHAALKNGHTTPIGSARSSSPVLVEEEPERSLRNLTPEEESKKRLGSTGSQPNSEAEPGPEHAPKQPLLPPKRPLSSSCEAKEVPAGSTARSVSSTSGSTTVTSAATTAATDMTKTVKSFVGPTPAPAPAPRTLPAAPASANTAATTTAPAKQPPIPPPKPAQRNSNPIIAELSQAMNSGTVLSKPSPPLPPKRGIPSTSIPSLEPAASFTTKTANDQREKTVSLCLEPPLIIPPSSPSPPLPTHIPPEPPRSPLVPAKTFQIVPEVEFSSSSDLFQDISQQEDQKTEVPKKIQDQSFGESHIPSRLPPLPLHIRIQQALTSPLPVTPPLEGTHRAHSLLFENSDSFSEDTGTLGRTRSLPITIEMLKVPDDEEEEQTCPFVEDVTSTSATPSLPLCLREEEKESDSDSEGPIKYRDEEEDDDDDESHQSALANRVKRKDTLAMKLSSRPSEPETNLNSWPRKSKEEWNEIRHQIGNTLIRRLSQRPTAEELEQRNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAHDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHVDSKHFTRYHRP
uniprot
proteins
function
FUNCTION: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway. {ECO:0000269|PubMed:17609112, ECO:0000269|PubMed:22215812}.
uniprot
proteins
mass_dalton
76632
uniprot
proteins
mutagenesis
MUTAGEN 650; /note="R->P: In humdy; failure to close the neural tube and optic fissure, causing exencephaly and retinal coloboma and common birth defects. Specifically disrupts interaction with PPP1CA while it does not affect interaction with actin."; /evidence="ECO:0000269|PubMed:17609112
uniprot
proteins
protein_family
Phosphatase and actin regulator family
uniprot
proteins
pubmed
15107502
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17609112
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22215812
uniprot
proteins
sequence_length
694
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell projection, lamellipodium.
uniprot
proteins