L3mbtl1
entrez
311613
canonical
uniprot
D3ZWK4
canonical
ensembl
ENSRNOG00000007044
resolver
ensp
ENSRNOP00000049326
resolver
enst
ENSRNOT00000045677
resolver
genesymbol
L3mbtl1
resolver
genesymbol_syn
L3mbt
resolver
genesymbol_syn
L3mbtl
resolver
uniprot
D4A6H6
resolver
uniprot_entry
LMBL1_RAT
resolver
uniprot_sec
D4A6H6
resolver
amino_acid_sequence
MEGHSDMEIIRAVKGSATGEINVHLVARDSAGSHPHLPTTTFIIPTNAATLGLPSTALDVSYPREPVHVGAAERVAGSEPVTATILPQLSTGPGTNSTVRLLDWTGVSAPLAGSGMRFRINEYATQNMIEIERPRSPEQRHEGGTAGREADIQHPDVHKDPQEVIPQEPSVDAGSCKCQTCGPQQSIGLDVGSSGDRCPQPFQKRSVIVENSGCTVASELIKPMKKRKHKEYQSPSEESEPEAMKQGKGKDPDREPTPGTSENEEWSRSQLVSSEKKEGWSWESYLEEQKAVTAPVSLFQDSQAVTHNKNGFKLGMKLEGVDPQHPSMYFVLTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQYLRSTKAQAAPKHLFVSQSHSPPPVGFQVGMKLEAVDRMNPSLVCVASVTDVVASRFLVHFDDWDDTYDYWCDASSPYIHPVGWCQKQGKPLTPPQDYPDPDSFCWEKYLEETGTSAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKLHFDGWSHNYDFWIDADHPDIHPAGWCSKTGHPLEPPLRPRESSSASPGGCPPLSHRSPPHTKTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSETTARKKNQSNLSPRKKPRHQGRIGRPPKYRKMPDEDFQALPPSVVHQSLFMSTLPTHADRPLSVCWEQHCKLLPGVAGISASAVSKWTIEEVFGFVQTLTGSEDQARLFKEEMIDGEAFLLLTQADIVKIMSVKLGPALKIYNAILMFKNNDDVFK
uniprot
proteins
function
FUNCTION: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
91761
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated in a VCP/p97-dependent way following DNA damage, leading to its removal from DNA damage sites, promoting accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited to DNA damage sites. {ECO:0000250}.
uniprot
proteins
sequence_length
826
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Excluded from the nucleolus. Does not colocalize with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex (By similarity). {ECO:0000250}.
uniprot
proteins