Rasgrp4
entrez
233046
canonical
uniprot
Q8BTM9
canonical
ensembl
ENSMUSG00000030589
resolver
ensp
ENSMUSP00000032811
resolver
ensp
ENSMUSP00000124183
resolver
ensp
ENSMUSP00000125137
resolver
genesymbol
Rasgrp4
resolver
uniprot
Q3TNQ1
resolver
uniprot
Q3TRL5
resolver
uniprot
Q3U3I4
resolver
uniprot
Q811P7
resolver
uniprot
Q8BKV7
resolver
uniprot
Q91ZC8
resolver
uniprot
Q920A2
resolver
uniprot_entry
GRP4_MOUSE
resolver
uniprot_sec
Q3TNQ1
resolver
uniprot_sec
Q3TRL5
resolver
uniprot_sec
Q3U3I4
resolver
uniprot_sec
Q811P7
resolver
uniprot_sec
Q8BKV7
resolver
uniprot_sec
Q91ZC8
resolver
uniprot_sec
Q920A2
resolver
amino_acid_sequence
MNRKDIKRKSHQECSGKAGGRGRSRQARRHKTCPTPREISKVMASMNLGVLSESSCSEDELLEECIRCFDSAGSLRRGDHILKMVLTMHSWVLPSSELAARLLTSYQKAAKDAQELRQLQICYLVRYWLTHHHEAVHQEPQLEAVISRFWTTVAQEGNMAQRSLGDASSLLSPGGPGPPPPMSSPGLGKKRKVSLLFDHLETEELAQHLTYLEFRSFQAITPQDLRGYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPAQRAQVLDKFIRVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHVHLSPDSTKALLELTELLSSHNNYAHYRRTWAGCTGFRLPVLGVHLKDLVSLYEAHPDRLPDGRLHLPKLNSLYLRLQELMALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFKAPVVVEWAQGVTPKPDSVTLGQHVEQLVESVFKNYDPEGRGSISLEDFERLSGNFPFACHGLHPPPRHGSGSFSREELTKYLLHASAICSKLGLAFLHAFQEVTFRKPTFCHSCSGFLWGVTKQGYRCRDCGLCCHRHCRDQVRVECKKRPETKGDPGPPGAPVPATSLPPANCGSEESLSYTLSPDPESGCHLRHAWTQTESSHSSWEPEVVPCPARVLPSRASSKPSV
uniprot
proteins
function
FUNCTION: Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP (PubMed:12817022, PubMed:22728827). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting Ras-mediated activation of PIK3CG/PI3Kgamma to promote neutrophil functional responses (PubMed:22728827). In CD117(+) dendritic cells and mast cells, participates in an lipopolysaccharide (LPS)-activated signaling pathway that stimulates the production of interferon-gamma and other pro-inflammatory cytokines by natural killer (NK) cells (PubMed:26982501). May function in mast cell differentiation (PubMed:12817022). Does not appear to be required for the development of B-cells, DC-cells, T-cells, or NK-cells (PubMed:26982501). {ECO:0000269|PubMed:12817022, ECO:0000269|PubMed:22728827, ECO:0000269|PubMed:26982501}.; FUNCTION: [Isoform 1]: Binds diacylglycerol (DAG). {ECO:0000269|PubMed:17523924}.; FUNCTION: [Isoform 2]: Unable to bind diacylglycerol (DAG). {ECO:0000269|PubMed:17523924}.
uniprot
proteins
mass_dalton
74907
uniprot
proteins
protein_family
RASGRP family
uniprot
proteins
pubmed
11956218
uniprot
proteins
pubmed
12817022
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17523924
uniprot
proteins
pubmed
22728827
uniprot
proteins
pubmed
26982501
uniprot
proteins
sequence_length
673
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11956218}. Cell membrane {ECO:0000269|PubMed:11956218, ECO:0000269|PubMed:12817022}. Note=Recruited to membranes upon activation by DAG. {ECO:0000269|PubMed:12817022}.
uniprot
proteins