Grm2
entrez
24415
canonical
uniprot
P31421
canonical
ensembl
ENSRNOG00000013171
resolver
ensembl
ENSRNOG00055011818
resolver
ensembl
ENSRNOG00060017564
resolver
ensembl
ENSRNOG00065008268
resolver
ensp
ENSRNOP00000017607
resolver
ensp
ENSRNOP00000091771
resolver
ensp
ENSRNOP00055016160
resolver
ensp
ENSRNOP00060024237
resolver
ensp
ENSRNOP00065009696
resolver
enst
ENSRNOT00000017607
resolver
enst
ENSRNOT00055020073
resolver
enst
ENSRNOT00060030031
resolver
enst
ENSRNOT00065013122
resolver
genesymbol
Grm2
resolver
genesymbol_syn
Gprc1b
resolver
genesymbol_syn
Mglur2
resolver
uniprot_entry
GRM2_RAT
resolver
amino_acid_sequence
MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL
uniprot
proteins
function
FUNCTION: Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (By similarity). Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling (By similarity). Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization (By similarity). {ECO:0000250|UniProtKB:Q14416, ECO:0000250|UniProtKB:Q14BI2}.
uniprot
proteins
mass_dalton
95774
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
pubmed
11850456
uniprot
proteins
pubmed
1309649
uniprot
proteins
sequence_length
872
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Synapse {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 568..590; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 605..625; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 637..655; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 680..700; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 726..747; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 761..783; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 794..819; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins