HIRA
entrez
7290
canonical
uniprot
P54198
canonical
ensembl
ENSG00000100084
resolver
ensp
ENSP00000263208
resolver
genesymbol
HIRA
resolver
genesymbol_syn
DGCR1
resolver
genesymbol_syn
HIR
resolver
genesymbol_syn
TUPLE1
resolver
hgnc
HGNC:4916
resolver
uniprot
Q05BU9
resolver
uniprot
Q8IXN2
resolver
uniprot_entry
HIRA_HUMAN
resolver
uniprot_sec
Q05BU9
resolver
uniprot_sec
Q8IXN2
resolver
amino_acid_sequence
MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLKYQRRQQQQQLDQKSAATREMGSATSVAGVVNGESLEDIRKNLLKKQVETRTADGRRRITPLCIAQLDTGDFSTAFFNSIPLSGSLAGTMLSSHSSPQLLPLDSSTPNSFGASKPCTEPVVAASARPAGDSVNKDSMNATSTPAALSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPALTSMTPTAVERLKEQNLVKELRPRDLLESSSDSDEKVPLAKASSLSKRKLELEVETVEKKKKGRPRKDSRLMPVSLSVQSPAALTAEKEAMCLSAPALALKLPIPSPQRAFTLQVSSDPSMYIEVENEVTVVGGVKLSRLKCNREGKEWETVLTSRILTAAGSCDVVCVACEKRMLSVFSTCGRRLLSPILLPSPISTLHCTGSYVMALTAAATLSVWDVHRQVVVVKEESLHSILAGSDMTVSQILLTQHGIPVMNLSDGKAYCFNPSLSTWNLVSDKQDSLAQCADFRSSLPSQDAMLCSGPLAIIQGRTSNSGRQAARLFSVPHVVQQETTLAYLENQVAAALTLQSSHEYRHWLLVYARYLVNEGFEYRLREICKDLLGPVHYSTGSQWESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQLDILRDK
uniprot
proteins
function
FUNCTION: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}.
uniprot
proteins
mass_dalton
111835
uniprot
proteins
mutagenesis
MUTAGEN 449..458; /note="Missing: Impairs binding to ASF1A."; /evidence="ECO:0000269|PubMed:16980972"; MUTAGEN 458..460; /note="RRR->AKK: Abrogates binding to ASF1A."; MUTAGEN 458..460; /note="RRR->KKK: Impairs binding to ASF1A."; MUTAGEN 458..459; /note="RR->AK: Impairs binding to ASF1A."; MUTAGEN 458; /note="R->A: Impairs binding to ASF1A."; MUTAGEN 458; /note="R->K: Impairs binding to ASF1A; when associated with K-460."; MUTAGEN 459..468; /note="Missing: Abrogates binding to ASF1A."; /evidence="ECO:0000269|PubMed:16980972"; MUTAGEN 459; /note="R->A: Abrogates binding to ASF1A."; /evidence="ECO:0000269|PubMed:16980972"; MUTAGEN 460; /note="R->A: Abrogates binding to ASF1A."; /evidence="ECO:0000269|PubMed:16980972"; MUTAGEN 460; /note="R->K: Impairs binding to ASF1A; when associated with K-458."; /evidence="ECO:0000269|PubMed:16980972"; MUTAGEN 461; /note="I->D: Abrogates binding to ASF1A."; /evidence="ECO:0000269|PubMed:16980972"; MUTAGEN 464; /note="L->D: Impairs binding to ASF1A."; /evidence="ECO:0000269|PubMed:16980972"; MUTAGEN 466; /note="I->D: Impairs binding to ASF1A."; /evidence="ECO:0000269|PubMed:16980972"; MUTAGEN 555; /note="T->A: Impairs phosphorylation by CDK2."; /evidence="ECO:0000269|PubMed:11238922"; MUTAGEN 628..631; /note="KRKL->AAAA: Impairs binding to CCNA1 and phosphorylation by CDK2."; /evidence="ECO:0000269|PubMed:11238922
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000269|PubMed:15561718}.; PTM: Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-555 in vitro. Also phosphorylated on Thr-555 and Ser-687 in vivo. {ECO:0000269|PubMed:11238922}.
uniprot
proteins
protein_family
WD repeat HIR1 family
uniprot
proteins
pubmed
11238922
uniprot
proteins
pubmed
12370293
uniprot
proteins
pubmed
14680630
uniprot
proteins
pubmed
14718166
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15561718
uniprot
proteins
pubmed
15621527
uniprot
proteins
pubmed
16980972
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19029251
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28334823
uniprot
proteins
pubmed
7633437
uniprot
proteins
pubmed
8111380
uniprot
proteins
pubmed
8681138
uniprot
proteins
pubmed
9063745
uniprot
proteins
pubmed
9710638
uniprot
proteins
sequence_length
1017
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.
uniprot
proteins