Spi1
entrez
20375
canonical
uniprot
P17433
canonical
ensembl
ENSMUSG00000002111
resolver
ensp
ENSMUSP00000002180
resolver
enst
ENSMUST00000002180
resolver
genesymbol
Spi1
resolver
genesymbol_syn
Sfpi-1
resolver
genesymbol_syn
Sfpi1
resolver
uniprot
Q3U5L4
resolver
uniprot
Q99L57
resolver
uniprot_entry
Q3U5L4_MOUSE
resolver
uniprot_entry
SPI1_MOUSE
resolver
uniprot_sec
Q99L57
resolver
activity_regulation
ACTIVITY REGULATION: Transcriptional activity at macrophage-specific genes is inhibited by interaction with GFI1, which results in inhibition of SPI1-induced macrophage differentiation of myeloid progenitor cells, but not that of the granulocyte lineage. {ECO:0000269|PubMed:17197705}.
uniprot
proteins
amino_acid_sequence
MLQACKMEGFSLTAPPSDDLVTYDSELYQRPMHDYYSFVGSDGESHSDHYWDFSAHHVHNNEFENFPENHFTELQSVQPPQLQQLYRHMELEQMHVLDTPMVPPHTGLSHQVSYMPRMCFPYQTLSPAHQQSSDEEEGERQSPPLEVSDGEADGLEPGPGLLHGETGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGEVLGRGGLAERRLPPH
uniprot
proteins
disease_involvement
DISEASE: Note=May be involved in murine acute Friend erythroleukemia. It is a target region for SFFV proviral insertion. {ECO:0000269|PubMed:1985210, ECO:0000269|PubMed:2594367}.
uniprot
proteins
function
FUNCTION: Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites (PubMed:8079170). Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (By similarity). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition (PubMed:8079170). Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:2180582). In vitro can bind RNA and interfere with pre-mRNA splicing (PubMed:8626664). {ECO:0000250|UniProtKB:P17947, ECO:0000250|UniProtKB:Q6BDS1, ECO:0000269|PubMed:2180582, ECO:0000269|PubMed:8079170, ECO:0000269|PubMed:8626664}.
uniprot
proteins
mass_dalton
31349
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17197705
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
1985210
uniprot
proteins
pubmed
2180582
uniprot
proteins
pubmed
2594367
uniprot
proteins
pubmed
7594592
uniprot
proteins
pubmed
8079170
uniprot
proteins
pubmed
8602247
uniprot
proteins
pubmed
8626664
uniprot
proteins
sequence_length
272
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P17947}.
uniprot
proteins