Kcnq4
entrez
298496
canonical
uniprot
Q9JK96
canonical
ensembl
ENSRNOG00000060435
resolver
ensp
ENSRNOP00000073695
resolver
ensp
ENSRNOP00000107130
resolver
enst
ENSRNOT00000087445
resolver
enst
ENSRNOT00000126081
resolver
genesymbol
Kcnq4
resolver
uniprot
A0A0G2K666
resolver
uniprot
A0ABK0LXG6
resolver
uniprot_entry
A0ABK0LXG6_RAT
resolver
uniprot_entry
KCNQ4_RAT
resolver
uniprot_sec
A0A0G2K666
resolver
activity_regulation
ACTIVITY REGULATION: Two molecules of phosphatidylinositol-4,5-bisphosphate (PIP2-I and PIP2-II) are essential to activate KCNQ4 channel by inducing the coupling of the voltage-sensing domain (VSD) and the pore-forming domain (PD). Upon channel activation, PIP2-I and PIP2-II disrupt the VSD-calmodulin/CALM interaction, causing the release of CALM from the VSD which triggers the opening of the gate. Calcium suppresses KCNQ4 channel current through calcium-bound CALM C-terminus. Therefore CALM acts as calcium sensor that controls channel activity. {ECO:0000250|UniProtKB:P56696}.
uniprot
proteins
amino_acid_sequence
MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIIRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDTSRAYLTATWYYYDSILPSFRELALLFEHIQRARNGGLRPLEVRRAPVPDGAASRYPPVATCHRPGSASFCPGESSRMGIKDRIRMSSSQKRTGPSKQHLAPPPIPTSPSSEQVGEASSPSKVQKSWSFNDRTRFRASLRLKPRCSTEEGPSEEVAEEKSYQCELTVDDVMPTVKTVIRSVRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQARVDQIVGRGPGDRKTREKGDKGPSDTEAVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGTVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of sensory cells excitability in the cochlea. KCNQ4/Kv7.4 channel is composed of 4 pore-forming subunits assembled as tetramers. Promotes the outflow of potassium ions in the repolarization phase of action potential which plays a role in regulating membrane potential of excitable cells. The channel conducts a slowly activating and deactivating current. Current often shows some inward rectification at positive potentials. Channel may be selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) = Rb(+) > Cs(+) > Na(+). Important for normal physiological function of inner ear such as sensory perception of sound. {ECO:0000250|UniProtKB:P56696}.
uniprot
proteins
mass_dalton
77061
uniprot
proteins
protein_family
KQT (TC 1.A.1.15) subfamily
uniprot
proteins
protein_family
Kv7.4/KCNQ4 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
11042367
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
695
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basal cell membrane {ECO:0000269|PubMed:11042367}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56696}. Note=Situated at the basal membrane of cochlear outer hair cells. {ECO:0000269|PubMed:11042367}.
uniprot
proteins
transmembrane_region
TRANSMEM 97..118; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:P56696"; TRANSMEM 130..152; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:P56696"; TRANSMEM 169..191; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:P56696"; TRANSMEM 203..223; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:P56696"; TRANSMEM 236..258; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:P56696"; TRANSMEM 294..322; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:P56696
uniprot
proteins