SPSB4
entrez
92369
canonical
uniprot
Q96A44
canonical
ensembl
ENSG00000175093
resolver
ensp
ENSP00000311609
resolver
ensp
ENSP00000557636
resolver
ensp
ENSP00000601096
resolver
ensp
ENSP00000601097
resolver
ensp
ENSP00000601098
resolver
ensp
ENSP00000601099
resolver
ensp
ENSP00000623774
resolver
enst
ENST00000310546
resolver
enst
ENST00000887577
resolver
enst
ENST00000931037
resolver
enst
ENST00000931038
resolver
enst
ENST00000931039
resolver
enst
ENST00000931040
resolver
enst
ENST00000953715
resolver
genesymbol
SPSB4
resolver
genesymbol_syn
SSB4
resolver
hgnc
HGNC:30630
resolver
uniprot_entry
SPSB4_HUMAN
resolver
amino_acid_sequence
MGQKLSGSLKSVEVREPALRPAKRELRGAEPGRPARLDQLLDMPAAGLAVQLRHAWNPEDRSLNVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATARAPLHSVGYTALVGSDAESWGWDLGRSRLYHDGKNQPGVAYPAFLGPDEAFALPDSLLVVLDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCRRSIRSALGRQRLQDISSLPLPQSLKNYLQYQ
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 (PubMed:28931592). Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 (PubMed:26392558). {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:21199876, ECO:0000269|PubMed:26392558, ECO:0000269|PubMed:28931592}.
uniprot
proteins
mass_dalton
30179
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
SPSB family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15601820
uniprot
proteins
pubmed
15713673
uniprot
proteins
pubmed
20561531
uniprot
proteins
pubmed
21199876
uniprot
proteins
pubmed
26392558
uniprot
proteins
pubmed
28931592
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:21199876}. Note=Exhibits a diffuse cytosolic localization. {ECO:0000269|PubMed:21199876}.
uniprot
proteins