Acadsb
entrez
25618
canonical
uniprot
P70584
canonical
ensembl
ENSRNOG00000020624
resolver
ensembl
ENSRNOG00055030359
resolver
ensembl
ENSRNOG00060032539
resolver
ensembl
ENSRNOG00065012861
resolver
ensp
ENSRNOP00000096562
resolver
ensp
ENSRNOP00055043703
resolver
ensp
ENSRNOP00060046604
resolver
ensp
ENSRNOP00065016279
resolver
enst
ENSRNOT00000101166
resolver
enst
ENSRNOT00055052880
resolver
enst
ENSRNOT00060056402
resolver
enst
ENSRNOT00065021104
resolver
genesymbol
Acadsb
resolver
uniprot_entry
ACDSB_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethylmaleimide, hydroxymercuribenzoate, methyl mercury iodide and heavy metals such as Hg2+, Cu2+, and Ag2+. {ECO:0000269|PubMed:6874697}.
uniprot
proteins
amino_acid_sequence
MAVSAFQLWRAGGLLRRNFLTHSSSWKIPPRVLKSSQPEALLSVTNNALCFAPLQTFTDEDIMMQKAVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGMMGIEVEAKYGGTEASFLCSVLVIEELAKVDASVALLCDIQNTVINKLFRKHGTEEQKATYLPKLVTEKLGSFCLSEAGAGSDSFALKTRADKSGNYYVINGSKMWISNAEHAELFLVFANVDPPSGYRGITCFLVDRDTEGFQIGRRENKMGIRASSTCQLTFENVKVPETSVLGKIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERMQFGKRIFDFQGLQHQVAHVATQLEAARLLTYNAARLVEAGRPFIKEASMAKYYASEVAGLTTSKCIEWMGGVGYTKDYPVEKFFRDAKIGTIYEGTSNIQLNTIAKHIDAEY
uniprot
proteins
ec_number
1.3.8.1
uniprot
proteins
ec_number
1.3.8.5
uniprot
proteins
function
FUNCTION: Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA) (PubMed:12855692, PubMed:6874697, PubMed:8660691). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (butanoyl-CoA) (PubMed:12855692, PubMed:6874697, PubMed:8660691). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway (By similarity). Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug (PubMed:8660691). {ECO:0000250|UniProtKB:P45954, ECO:0000269|PubMed:12855692, ECO:0000269|PubMed:6874697, ECO:0000269|PubMed:8660691}.
uniprot
proteins
mass_dalton
47824
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; mitochondrial fatty acid beta-oxidation. {ECO:0000269|PubMed:6874697, ECO:0000269|PubMed:8660691}.; PATHWAY: Amino-acid degradation; L-isoleucine degradation. {ECO:0000250|UniProtKB:P45954}.
uniprot
proteins
protein_family
Acyl-CoA dehydrogenase family
uniprot
proteins
pubmed
12855692
uniprot
proteins
pubmed
6874697
uniprot
proteins
pubmed
8660691
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:6874697}.
uniprot
proteins