Tut4
entrez
230594
canonical
uniprot
B2RX14
canonical
ensembl
ENSMUSG00000034610
resolver
ensp
ENSMUSP00000044836
resolver
ensp
ENSMUSP00000095538
resolver
ensp
ENSMUSP00000120172
resolver
ensp
ENSMUSP00000337622
resolver
enst
ENSMUST00000043368
resolver
enst
ENSMUST00000097925
resolver
genesymbol
Tut4
resolver
genesymbol_syn
Kiaa0191
resolver
genesymbol_syn
Zcchc11
resolver
uniprot
A2A8R7
resolver
uniprot
A2A8R8
resolver
uniprot
Q3UYT6
resolver
uniprot
Q3V3D5
resolver
uniprot
Q5DU43
resolver
uniprot
Q9EQN6
resolver
uniprot_entry
A2A8R7_MOUSE
resolver
uniprot_entry
Q3V3D5_MOUSE
resolver
uniprot_entry
Q9EQN6_MOUSE
resolver
uniprot_entry
TUT4_MOUSE
resolver
uniprot_sec
A2A8R8
resolver
uniprot_sec
Q3UYT6
resolver
uniprot_sec
Q5DU43
resolver
amino_acid_sequence
MEEPKTSKNENHEPKKNIICEESKAVKIISNQTLKPRNDKSEIGTSSLNRNSSKKTKQNDICIEKTEAKSCKVNAASVPGPKDLGLVHRDQSHCKMKKLPNSPMKAQKGSSQTKLEKTPSLQTKAEKVPKSPNLPVKAEKAPCTTAEATTEKALNSQRKEENTPTSQMKLQKTPRSPLEPENVPSLLLKENVKQTESQQTGKKLTSSFVSMDKRKSEALQGEKSALENSSLSQKQQTQTDNIADSDDSASGIEDTADDLSKMKSEESNKENSSEMDYLENATVIDESALTPEQRLGLKQAEERLERDHIFRLEKRSPEYTNCRYLCKLCLIHIENIQGAHKHIKEKRHKKNILEKQEESELRSLPSPSSAHLAALSVAVVELAKEQGITDDDLRIRQDIVEEMSKVIMTFLPECSLRLYGSSLTKFALKSSDVNIDIKFPPKMNHPDLLIQVLGILKKSALYIDVESDFHAKVPVVVCKDRKSALLCRVSAGNDMACLTTDLLAALGKVEPVFTPLVLAFRYWAKLCYIDSQTDGGIPSYCFALMVMFFLQQRKPPLLPCLLGSWIEGFDPKRMDDFQLKGIVEEKFVKWEYNSSSATEKNLIADENKAKADEPKDDTKKTETDNQSNAAKAKHGKSPLTLEAPNQVPLGQLWLELLKFYTLDFALEEYVICVRIQDILTRENKNWPKRRIAIEDPFSVKRNVARSLNSQLVYEYVVERFRAAYRYFACPQKKGGNKSTMDPKKKEKGKLSSKKPVKSDCSATNCCILGESAEKIHMERGQPAKHDETEFTSQRCIVDNDSLLVNELGLANHGQDSSSLSTASGGSDLKQKSAEKQGDLTPSETSLKKELSQCICIGTPDGAESAGTDCRSNLEMDSSHQIVCNNVSATSCNCKATEVTSDLVDEDNLPSQELYYVFDKFILTSGKPPTIVCSICKKDGHSKNDCPEDFRKIDLKPLPPMTNRFREILDLVCKRCFDELSPPCSEQHNREQILIGLEKFIQKEYDEKARLCLFGSSKNGFGFRDSDLDICMTLEGHENAEKLNCKEIIENLAKILKRHPGLRNILPITTAKVPIVKFEHRRSGLEGDISLYNTLAQHNTRMLATYAAIDPRVQYLGYTMKVFAKRCDIGDASRGSLSSYAYILMVLYFLQQRKPPVIPVLQEIFDGKQIPQRMVDGWNAFFFDKTEELKKRLPSLGKNTESLGELWLGLLRFYTEEFDFKEYVISIRQKKLLTTFEKQWTSKCIAIEDPFDLNHNLGAGVSRKMTNFIMKAFINGRKLFGTPFYPLIGREAEYFFDSRVLTDGELAPNDRCCRVCGKIGHYMKDCPKRKRLKKKDSEEEKEGNEEEKDSRDLLDSRDLRCFICGDAGHVRRECPEVKMARQRNSSVAAAQLVRNLVNAQQVAGSAQQQSDQSIRTRQSSECSDSPSYSPQPQPFPQNSPQPSALPPPPSQPGSQPKLGPPQQGGQPPHQVQMPLYNFPQSPPAHYSPMHSMGLLPMHPLQIPAPSWPIHGPMLHSAPGSTPSNIGLNDPSIIFAQPAARPMAIPSPSHDGHWPRTVAPNSLVNNGAVGNSEPRFRGLNPPIPWEHAPRHFPLVPASWPYGLHQNFMHQGNPRFQPKPFYAQADRCATRRCRERCPHPPRGNVSE
uniprot
proteins
ec_number
2.7.7.52
uniprot
proteins
function
FUNCTION: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:28792939). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (PubMed:28792939). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (By similarity). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (By similarity). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (By similarity). Does not play a role in replication-dependent histone mRNA degradation (By similarity). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:22898984, PubMed:28671666, PubMed:28792939). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (By similarity). {ECO:0000250|UniProtKB:Q5TAX3, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22898984, ECO:0000269|PubMed:28671666, ECO:0000269|PubMed:28792939}.
uniprot
proteins
mass_dalton
184650
uniprot
proteins
mutagenesis
MUTAGEN 326; /note="C->A: No effect on basal uridylation activity, but loss of LIN28A-enhanced uridylation; when associated with A-329."; /evidence="ECO:0000269|PubMed:22898984"; MUTAGEN 329; /note="C->A: No effect on basal uridylation activity, but loss of LIN28A-enhanced uridylation; when associated with A-326."; /evidence="ECO:0000269|PubMed:22898984"; MUTAGEN 1026; /note="D->A: Loss of nucleotidyltransferase activity and oocytes are unable to support early embryonic development; when associated with A-1028."; /evidence="ECO:0000269|PubMed:19701194, ECO:0000269|PubMed:28792939"; MUTAGEN 1028; /note="D->A: Loss of nucleotidyltransferase activity and oocytes are unable to support early embryonic development; when associated with A-1026."; /evidence="ECO:0000269|PubMed:19701194, ECO:0000269|PubMed:28792939
uniprot
proteins
protein_family
DNA polymerase type-B-like family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19701194
uniprot
proteins
pubmed
19703396
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22898984
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
28671666
uniprot
proteins
pubmed
28792939
uniprot
proteins
sequence_length
1644
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5TAX3}. Cytoplasm {ECO:0000269|PubMed:19703396}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q5TAX3}. Note=Mainly cytoplasmic (PubMed:19703396). Translocates into the cytoplasm following treatment of the cell with LPS. Co-enriched in cytoplasmic foci with MOV10. {ECO:0000250|UniProtKB:Q5TAX3, ECO:0000269|PubMed:19703396}.
uniprot
proteins