SORBS3
entrez
10174
canonical
uniprot
O60504
canonical
ensembl
ENSG00000120896
resolver
ensp
ENSP00000240123
resolver
ensp
ENSP00000429764
resolver
ensp
ENSP00000654343
resolver
genesymbol
SORBS3
resolver
genesymbol_syn
SCAM1
resolver
hgnc
HGNC:30907
resolver
uniprot
Q5BJE4
resolver
uniprot
Q6NX54
resolver
uniprot
Q96FY4
resolver
uniprot
Q9UQE4
resolver
uniprot_entry
VINEX_HUMAN
resolver
uniprot_sec
Q5BJE4
resolver
uniprot_sec
Q6NX54
resolver
uniprot_sec
Q96FY4
resolver
uniprot_sec
Q9UQE4
resolver
amino_acid_sequence
MQGPPRSLRAGLSLDDFIPGHLQSHIGSSSRGTRVPVIRNGGSNTLNFQFHDPAPRTVCNGGYTPRRDASQHPDPAWYQTWPGPGSKPSASTKIPASQHTQNWSATWTKDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFEEPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV
uniprot
proteins
function
FUNCTION: Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
uniprot
proteins
mass_dalton
75341
uniprot
proteins
mutagenesis
MUTAGEN 649; /note="W->F: Loss of SOS-binding ability."; /evidence="ECO:0000269|PubMed:9885244"; MUTAGEN 667; /note="Y->V: Loss of SOS-binding ability."; /evidence="ECO:0000269|PubMed:9885244
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-530 by MAPK1/ERK2 during cell spreading. {ECO:0000250}.
uniprot
proteins
pubmed
10585480
uniprot
proteins
pubmed
12660241
uniprot
proteins
pubmed
15242778
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16302969
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18662323
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19807924
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9885244
uniprot
proteins
sequence_length
671
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Alpha]: Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform Beta]: Cell junction {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites, vinexin beta was also found in the nucleus. {ECO:0000250}.
uniprot
proteins