ADTRP
entrez
84830
canonical
uniprot
Q96IZ2
canonical
ensembl
ENSG00000111863
resolver
ensp
ENSP00000229583
resolver
ensp
ENSP00000368726
resolver
ensp
ENSP00000404416
resolver
ensp
ENSP00000669903
resolver
genesymbol
ADTRP
resolver
genesymbol_syn
C6orf105
resolver
hgnc
HGNC:21214
resolver
uniprot
B2R7T9
resolver
uniprot
B4DV39
resolver
uniprot
Q5THW1
resolver
uniprot_entry
ADTRP_HUMAN
resolver
uniprot_sec
B2R7T9
resolver
uniprot_sec
B4DV39
resolver
uniprot_sec
Q5THW1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-hydroxyhydantoin carbamate JJH260 and beta-lactone KC01. {ECO:0000269|PubMed:27018888}.
uniprot
proteins
amino_acid_sequence
MTKTSTCIYHFLVLSWYTFLNYYISQEGKDEVKPKILANGARWKYMTLLNLLLQTIFYGVTCLDDVLKRTKGGKDIKFLTAFRDLLFTTLAFPVSTFVFLAFWILFLYNRDLIYPKVLDTVIPVWLNHAMHTFIFPITLAEVVLRPHSYPSKKTGLTLLAAASIAYISRILWLYFETGTWVYPVFAKLSLLGLAAFFSLSYVFIASIYLLGEKLNHWKWGDMRQPRKKRK
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed:21868574). {ECO:0000269|PubMed:21868574, ECO:0000269|PubMed:27018888}.
uniprot
proteins
mass_dalton
26842
uniprot
proteins
mutagenesis
MUTAGEN 47; /note="T->A: Loss of hydrolase activity."; /evidence="ECO:0000269|PubMed:27018888"; MUTAGEN 131; /note="H->A: Loss of hydrolase activity."; /evidence="ECO:0000269|PubMed:27018888
uniprot
proteins
protein_family
AIG1 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21868574
uniprot
proteins
pubmed
27018888
uniprot
proteins
sequence_length
230
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21868574, ECO:0000269|PubMed:27018888}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalized with TFPI and CAV1 in lipid rafts. {ECO:0000269|PubMed:21868574}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 86..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins