PRSS3
entrez
5646
canonical
uniprot
P35030
canonical
ensembl
ENSG00000010438
resolver
ensp
ENSP00000340889
resolver
ensp
ENSP00000354280
resolver
ensp
ENSP00000368715
resolver
ensp
ENSP00000401828
resolver
enst
ENST00000361005
resolver
genesymbol
PRSS3
resolver
genesymbol_syn
PRSS4
resolver
genesymbol_syn
TRY3
resolver
genesymbol_syn
TRY4
resolver
hgnc
HGNC:9486
resolver
uniprot
A0A7P0MP65
resolver
uniprot
A8CED1
resolver
uniprot
A8CED3
resolver
uniprot
A9Z1Y4
resolver
uniprot
E7ES07
resolver
uniprot
F8W7P3
resolver
uniprot
P15951
resolver
uniprot
Q15665
resolver
uniprot
Q5VXV0
resolver
uniprot
Q6ISJ4
resolver
uniprot
Q7Z5F4
resolver
uniprot
Q9UQV3
resolver
uniprot_entry
A0A7P0MP65_HUMAN
resolver
uniprot_entry
Q7Z5F4_HUMAN
resolver
uniprot_entry
TRY3_HUMAN
resolver
uniprot_sec
A8CED1
resolver
uniprot_sec
A8CED3
resolver
uniprot_sec
A9Z1Y4
resolver
uniprot_sec
E7ES07
resolver
uniprot_sec
F8W7P3
resolver
uniprot_sec
P15951
resolver
uniprot_sec
Q15665
resolver
uniprot_sec
Q5VXV0
resolver
uniprot_sec
Q6ISJ4
resolver
uniprot_sec
Q9UQV3
resolver
activity_regulation
ACTIVITY REGULATION: Not inhibited by Kunitz-type trypsin inhibitors. {ECO:0000269|PubMed:18077447, ECO:0000269|PubMed:9099703}.
uniprot
proteins
amino_acid_sequence
MCGPDDRCPARWPGPGRAVKCGKGLAAARPGRVERGGAQRGGAGLELHPLLGGRTWRAARDADGCEALGTVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKDTIAANS
uniprot
proteins
ec_number
3.4.21.4
uniprot
proteins
function
FUNCTION: Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. {ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:14507909, ECO:0000269|PubMed:18077447, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0000269|PubMed:9099703}.
uniprot
proteins
mass_dalton
32529
uniprot
proteins
mutagenesis
MUTAGEN 257; /note="S->A: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:27810896
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
11827488
uniprot
proteins
pubmed
12021776
uniprot
proteins
pubmed
14507909
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18077447
uniprot
proteins
pubmed
19924134
uniprot
proteins
pubmed
2326201
uniprot
proteins
pubmed
25301953
uniprot
proteins
pubmed
27810896
uniprot
proteins
pubmed
6698368
uniprot
proteins
pubmed
8294000
uniprot
proteins
pubmed
9099703
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:6698368}.
uniprot
proteins