Acvr2a
entrez
29263
canonical
uniprot
P38444
canonical
ensembl
ENSRNOG00000065897
resolver
ensp
ENSRNOP00000007404
resolver
ensp
ENSRNOP00000083010
resolver
enst
ENSRNOT00000007404
resolver
enst
ENSRNOT00000113342
resolver
genesymbol
Acvr2a
resolver
genesymbol_syn
Actrii
resolver
genesymbol_syn
Acvr2
resolver
genesymbol_syn
ENSRNOG00000065897
resolver
uniprot
A0A8I5ZYE8
resolver
uniprot
F1MA24
resolver
uniprot_entry
A0A8I5ZYE8_RAT
resolver
uniprot_entry
AVR2A_RAT
resolver
uniprot_entry
F1MA24_RAT
resolver
amino_acid_sequence
MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWERDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHMMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSGGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCLGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
uniprot
proteins
ec_number
2.7.11.30
uniprot
proteins
function
FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6. {ECO:0000250|UniProtKB:P27037, ECO:0000250|UniProtKB:P27038}.
uniprot
proteins
mass_dalton
57893
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TGFB receptor subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
1385212
uniprot
proteins
pubmed
7916681
uniprot
proteins
sequence_length
513
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P27038}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 136..161; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins