Rtn2
entrez
20167
canonical
uniprot
O70622
canonical
ensembl
ENSMUSG00000030401
resolver
ensp
ENSMUSP00000032559
resolver
ensp
ENSMUSP00000104108
resolver
genesymbol
Rtn2
resolver
genesymbol_syn
Nspl1
resolver
uniprot
O70620
resolver
uniprot
Q3TUZ6
resolver
uniprot
Q6IM74
resolver
uniprot
Q6IM75
resolver
uniprot_entry
Q3TUZ6_MOUSE
resolver
uniprot_entry
Q6IM74_MOUSE
resolver
uniprot_entry
Q6IM75_MOUSE
resolver
uniprot_entry
RTN2_MOUSE
resolver
uniprot_sec
O70620
resolver
amino_acid_sequence
MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEDEEEETTSQDWGTPRELTFSYIAFDGVVGSGGRRDSVVRRPRPQGRSVSEPRDPPQQSGLGDSLESIPSLSQSPEPGRRGDPDPVPPAERPLEELRLRLDQLGWVVRSAGSGEDSATSSSTPLENEEPDGLEASEAGEETNLELRLAQSLHLQLEVLTPQLSPSSGTPQAHTPSPQRSQDSNSGPDDEPLLNVVEEHWRLLEQEPITAQCLDSTDQSEFMLEPLLLVADLLYWKDTRTSGAVFTGLMASLLCLLHFSIVSVAAHLALLGLCATISLRVYRKVLQAVHRGDGTNPFQAYLDMDLTLTREQTERLSQQIASHVVSTATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLVILGVVALFTVPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGTLAPTASVSGSKAKAE
uniprot
proteins
function
FUNCTION: Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity (By similarity). Enhances trafficking of the glutamate transporter SLC1A1/EAAC1 from the endoplasmic reticulum to the cell surface (By similarity). Plays a role in the translocation of SLC2A4/GLUT4 from intracellular membranes to the cell membrane which facilitates the uptake of glucose into the cell (PubMed:19720795). {ECO:0000250|UniProtKB:O75298, ECO:0000250|UniProtKB:Q6WN19, ECO:0000269|PubMed:19720795}.
uniprot
proteins
mass_dalton
51347
uniprot
proteins
pubmed
10672514
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19720795
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9530622
uniprot
proteins
sequence_length
471
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O75298}; Multi-pass membrane protein {ECO:0000255}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:19720795}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q6WN19}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000269|PubMed:19720795}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma, T-tubule {ECO:0000269|PubMed:19720795}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:10672514}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10672514}. Note=Localizes to intermediate filaments in mononucleated myoblasts and to Z lines in mature myotubes. {ECO:0000269|PubMed:10672514}.
uniprot
proteins
transmembrane_region
TRANSMEM 295..315; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 390..410; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins