LSM14A
entrez
26065
canonical
uniprot
Q8ND56
canonical
ensembl
ENSG00000257103
resolver
ensembl
ENSG00000262860
resolver
ensp
ENSP00000413964
resolver
ensp
ENSP00000446271
resolver
ensp
ENSP00000446451
resolver
ensp
ENSP00000576115
resolver
ensp
ENSP00000576117
resolver
ensp
ENSP00000576118
resolver
ensp
ENSP00000576120
resolver
ensp
ENSP00000576121
resolver
ensp
ENSP00000649598
resolver
ensp
ENSP00000756046
resolver
ensp
ENSP00000771183
resolver
genesymbol
LSM14A
resolver
genesymbol_syn
C19orf13
resolver
genesymbol_syn
FAM61A
resolver
genesymbol_syn
RAP55
resolver
genesymbol_syn
RAP55A
resolver
hgnc
HGNC:24489
resolver
uniprot
B4DTG6
resolver
uniprot
Q76LX7
resolver
uniprot
Q96AR3
resolver
uniprot
Q96K73
resolver
uniprot
Q96SN5
resolver
uniprot
Q9UFR3
resolver
uniprot_entry
LS14A_HUMAN
resolver
uniprot_sec
B4DTG6
resolver
uniprot_sec
Q76LX7
resolver
uniprot_sec
Q96AR3
resolver
uniprot_sec
Q96K73
resolver
uniprot_sec
Q96SN5
resolver
uniprot_sec
Q9UFR3
resolver
amino_acid_sequence
MSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQDTRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQVAPGAPSAPRRGRGGHRGGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLNAETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGGGRGGTFTAPRGFRGGFRGGRGGREFADFEYRKTTAFGP
uniprot
proteins
function
FUNCTION: Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}.
uniprot
proteins
mass_dalton
50530
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="Y->E: Abolished interaction with EIF4ENIF1/4E-T without affecting interaction with DDX6; when associated with E-29."; /evidence="ECO:0000269|PubMed:29510985"; MUTAGEN 29; /note="I->E: Abolished interaction with EIF4ENIF1/4E-T without affecting interaction with DDX6; when associated with E-22."; /evidence="ECO:0000269|PubMed:29510985"; MUTAGEN 296..298; /note="FDF->ADA: Abolished interaction with DDX6."; /evidence="ECO:0000269|PubMed:29510985"; MUTAGEN 305; /note="F->A: Abolished interaction with DDX6."; /evidence="ECO:0000269|PubMed:29510985"; MUTAGEN 369..371; /note="FFD->AAA: Does not affect interaction with DDX6."; /evidence="ECO:0000269|PubMed:29510985"; MUTAGEN 394..397; /note="ETFG->AAAA: Abolished interaction with DDX6."; /evidence="ECO:0000269|PubMed:29510985"; MUTAGEN 396; /note="F->A: Abolished interaction with DDX6."; /evidence="ECO:0000269|PubMed:29510985
uniprot
proteins
protein_family
LSM14 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16484376
uniprot
proteins
pubmed
17074753
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18723115
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26027925
uniprot
proteins
pubmed
26339800
uniprot
proteins
pubmed
29510985
uniprot
proteins
pubmed
31422817
uniprot
proteins
pubmed
31439631
uniprot
proteins
pubmed
32354837
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:32354837}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:26339800}. Cytoplasm, Stress granule {ECO:0000269|PubMed:16484376}.
uniprot
proteins