SNCB
entrez
6620
canonical
uniprot
Q16143
canonical
ensembl
ENSG00000074317
resolver
ensp
ENSP00000308057
resolver
ensp
ENSP00000377296
resolver
ensp
ENSP00000422223
resolver
ensp
ENSP00000424073
resolver
ensp
ENSP00000479489
resolver
ensp
ENSP00000532667
resolver
ensp
ENSP00000532668
resolver
ensp
ENSP00000532670
resolver
ensp
ENSP00000582615
resolver
ensp
ENSP00000582617
resolver
ensp
ENSP00000582618
resolver
ensp
ENSP00000616246
resolver
ensp
ENSP00000616250
resolver
ensp
ENSP00000616251
resolver
ensp
ENSP00000616253
resolver
ensp
ENSP00000616254
resolver
ensp
ENSP00000616256
resolver
ensp
ENSP00000616257
resolver
ensp
ENSP00000682535
resolver
enst
ENST00000310112
resolver
enst
ENST00000393693
resolver
enst
ENST00000506696
resolver
enst
ENST00000510387
resolver
enst
ENST00000614675
resolver
enst
ENST00000862608
resolver
enst
ENST00000862609
resolver
enst
ENST00000862611
resolver
enst
ENST00000912556
resolver
enst
ENST00000912558
resolver
enst
ENST00000912559
resolver
enst
ENST00000946187
resolver
enst
ENST00000946191
resolver
enst
ENST00000946192
resolver
enst
ENST00000946194
resolver
enst
ENST00000946195
resolver
enst
ENST00000946197
resolver
enst
ENST00000946198
resolver
genesymbol
SNCB
resolver
hgnc
HGNC:11140
resolver
uniprot
A0A087WVK3
resolver
uniprot
G4Y815
resolver
uniprot
G4Y816
resolver
uniprot
Q6IAX7
resolver
uniprot_entry
A0A087WVK3_HUMAN
resolver
uniprot_entry
G4Y815_HUMAN
resolver
uniprot_entry
G4Y816_HUMAN
resolver
uniprot_entry
SYUB_HUMAN
resolver
uniprot_sec
Q6IAX7
resolver
amino_acid_sequence
MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDPPQEEYQEYEPEA
uniprot
proteins
function
FUNCTION: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
uniprot
proteins
mass_dalton
14288
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation by G protein-coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II. {ECO:0000269|PubMed:10852916}.
uniprot
proteins
protein_family
Synuclein family
uniprot
proteins
pubmed
10852916
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8194594
uniprot
proteins
pubmed
9806846
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins