Map1lc3a
entrez
362245
canonical
uniprot
Q6XVN8
canonical
ensembl
ENSRNOG00000025443
resolver
ensembl
ENSRNOG00055024242
resolver
ensembl
ENSRNOG00060027125
resolver
ensembl
ENSRNOG00065028129
resolver
ensp
ENSRNOP00000032429
resolver
ensp
ENSRNOP00055033856
resolver
ensp
ENSRNOP00060039131
resolver
ensp
ENSRNOP00065039752
resolver
enst
ENSRNOT00000035060
resolver
enst
ENSRNOT00055041616
resolver
enst
ENSRNOT00060047048
resolver
enst
ENSRNOT00065048479
resolver
genesymbol
Map1lc3a
resolver
uniprot_entry
MLP3A_RAT
resolver
amino_acid_sequence
MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYASQETFGF
uniprot
proteins
function
FUNCTION: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. {ECO:0000250|UniProtKB:Q9H492}.
uniprot
proteins
mass_dalton
14272
uniprot
proteins
post_translational_modification
PTM: The precursor molecule is cleaved by ATG4 (ATG4A, ATG4B, ATG4C or ATG4D) to expose the glycine at the C-terminus and form the cytosolic form, LC3-I (PubMed:16874114). The processed form is then activated by APG7L/ATG7, transferred to ATG3 and conjugated to phosphatidylethanolamine (PE) phospholipid to form the membrane-bound form, LC3-II. During non-canonical autophagy, the processed form is conjugated to phosphatidylserine (PS) phospholipid. ATG4 proteins also mediate the delipidation of PE-conjugated forms. In addition, ATG4B and ATG4D mediate delipidation of ATG8 proteins conjugated to PS during non-canonical autophagy. ATG4B constitutes the major protein for proteolytic activation (By similarity). ATG4D is the main enzyme for delipidation activity (By similarity). {ECO:0000250|UniProtKB:Q91VR7, ECO:0000250|UniProtKB:Q9H492, ECO:0000269|PubMed:16874114}.; PTM: Phosphorylation at Ser-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE). {ECO:0000250|UniProtKB:Q9H492}.
uniprot
proteins
protein_family
ATG8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16874114
uniprot
proteins
pubmed
22421968
uniprot
proteins
pubmed
29934347
uniprot
proteins
sequence_length
121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250|UniProtKB:Q9H492}; Lipid-anchor {ECO:0000250|UniProtKB:Q9H492}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q9H492}; Lipid-anchor {ECO:0000250|UniProtKB:Q9H492}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q9H492}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91VR7}. Note=LC3-II binds to the autophagic membranes. {ECO:0000250|UniProtKB:Q9H492}.
uniprot
proteins