Peak1
entrez
244895
canonical
uniprot
Q69Z38
canonical
ensembl
ENSMUSG00000074305
resolver
ensp
ENSMUSP00000109901
resolver
ensp
ENSMUSP00000225425
resolver
ensp
ENSMUSP00000225426
resolver
enst
ENSMUST00000061552
resolver
genesymbol
Peak1
resolver
genesymbol_syn
Kiaa2002
resolver
genesymbol_syn
Sgk269
resolver
uniprot
E9QKY2
resolver
uniprot
Q8BX56
resolver
uniprot
Q8R365
resolver
uniprot_entry
PEAK1_MOUSE
resolver
uniprot_sec
E9QKY2
resolver
uniprot_sec
Q8BX56
resolver
uniprot_sec
Q8R365
resolver
amino_acid_sequence
MSACNTFTEHVWKPGECKNCFKPKSLHQLPPDSEKTPITHGSGKTNANHSNNHRVRSTGNFRPPVAKKPTIAVKPTMMVADGQSVCGELSIQEHCENKPVILGWNQNKTSLSQKPLNNNSEGDAEGFGSDPQQCANNDSAQKISNNNNGLTEVLKEIAGLEATPPVRGNETNARETFLGRINDCYKRSLERKIPPSCMTGSMKDSQGKHVILSGSAEVISNEGGRFCYPEFSSGEESEEDVLFSNMEEEHESWDESDEELLAMEIRMRGQPRFANFRANTLSPVRFFVSKKWNTIPLRNKSLQRICAVDYDDSYDEILNGYEENSGVSYGQGSVQSTISSDCTSPGSSFTEESRSETASSLSQKVCNGGISPGNPGNSKDIAETESNFESPPGNNEEKDESLTSKSSVKVPETHKAVLALRLQEKDGKIAVHTEKPESKASTDIAGQAVTISLVPVEEQTKPYRVVNLEQPLCKPYTVVDVSAAMASEHLGRPKIKGSSSTPNSPVTSPALTPGQINAHLKKSSAIRYQEVWTSSTSPRQKIPKIELSTGGPGPNVPPRKNCHKSAPTSPTATNISSKTIPVKSPNLSEIKFNSYNNAGMPPFPIIIHDEPSYARSSKNAIKVPIVINPNAYDNLAIYKSFLGTSGELSVKEKTTSVISHTYEEIETESKVSDSTPSKLTDCPQAKGFSNSTERKRGSVAQKVQEFNNCLNRGQSSPQRSYSSTHSSPAKIQRPTQEPAGKTEGAQGSQVPGSSSNSTREKASAVLCQIVASIQPPQTPPEAPQSSPKACSVEELYAVPPDADTTKSIPKNPPVRPKSLFTSQSSGEGEAHQTTESPTAKIQKDPSTKPVTSPPSKLVTSAQSEPPPPFPPPRSTSSPYHASNLLQRHFTNWTKPTSPTRSTEAESILHSEGSRRAADAKPKRWISFKSFFRRRKTDEEEEKEKEREKGKLVGLDGTVIHMLPPPPVQRHHWFTEAKGEASEKPAIVFMYRCDPDQGHLSVDQSKAGAEKGRAEEVLLRNSEEKKSSYLPSQIPDKACSRVTHEVAGELSPRDPRTPAGKQDGTSVTPTLPPPDLEREEEKDDTLDPTDVSPCSATYSNLGQSRAAMIPPKHPRHPKGAVDDAIAFGEKTDQEGLNASQPTPPPLPKKMIRANTEPISKDLQKAMESSLCVMANPTYDIDPNWDASSAGSSISYELKGLDVESYESLERPLHKERPVPSAANSISSLATLSVKDRFSNSMESLSSRRGLSYRQTRSIQKPQRQALYRGLDNREEVVGKLRSLHTDALKRLAVKCEDLFMAGQKDQLRFGVDSWSDFRLTSDKPCCEAGDAVYYTASYAKDPLSNYAVKICKSKAKESQQYYHSLAVRQSLPVHFNIQQDCGHFLAEVPSRLLPWEDPDAPEKAEDGTEDSEEEGKAETLGGNPEPCSETEPSQKENQRVTNRKQRSHVVVITREVPHLTVADFVRDSLAHHGNSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVQHQPGGAAQGPSPADPCPTLACPTRLIVSNFSQAKQKSHLVDPQILRDQSRLAPEIITATQYKKCDEFQTGILIYEMLHLPNPFDENPELKEKEYTRTDLPRIPLRSPYSWGLQQLASCLLNPNPSERILISDAKGILQCLLWGPREDLFQIFTTSATLAQKNALLQNWLDIKRTLLMIKFAEKSLDREGGISLEDWLCAQYLAFATTDSLSYIVKILQYR
uniprot
proteins
function
FUNCTION: Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling. {ECO:0000250|UniProtKB:Q9H792}.
uniprot
proteins
mass_dalton
191097
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine in a CSK-dependent manner in response to adhesion to fibronectin and to EGF stimulation (PubMed:20534451). Phosphorylation at Tyr-662 by a Src family kinase controls subcellular localization to focal adhesion and focal adhesion dynamics. Phosphorylation at Tyr-1177 is essential for binding to SHC1. Phosphorylation at Tyr-632 promotes interaction with tensin TNS3. {ECO:0000250|UniProtKB:Q9H792, ECO:0000269|PubMed:20534451}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20534451
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
35687021
uniprot
proteins
sequence_length
1735
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20534451}. Cell junction, focal adhesion {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:35687021}. Note=Colocalizes with actin (PubMed:20534451).
uniprot
proteins