GPN1
entrez
11321
canonical
uniprot
Q9HCN4
canonical
ensembl
ENSG00000198522
resolver
ensp
ENSP00000384255
resolver
ensp
ENSP00000398115
resolver
ensp
ENSP00000412170
resolver
ensp
ENSP00000476446
resolver
genesymbol
GPN1
resolver
genesymbol
XAB1
resolver
genesymbol_syn
MBDIN
resolver
genesymbol_syn
RPAP4
resolver
genesymbol_syn
XAB1
resolver
hgnc
HGNC:17030
resolver
uniprot
B4DQJ5
resolver
uniprot
B4DQM4
resolver
uniprot
B4DXU4
resolver
uniprot
B5MBZ5
resolver
uniprot
O76004
resolver
uniprot
Q53RZ9
resolver
uniprot_entry
GPN1_HUMAN
resolver
uniprot_entry
Q53RZ9_HUMAN
resolver
uniprot_sec
B4DQJ5
resolver
uniprot_sec
B4DQM4
resolver
uniprot_sec
B4DXU4
resolver
uniprot_sec
B5MBZ5
resolver
uniprot_sec
O76004
resolver
activity_regulation
ACTIVITY REGULATION: Adopts a GDP-bound closed conformation and a GTP-bound open conformation with a hydrophobic pocket and switch from one to another by the binding of RNAPII subunit-derived hydrophobic peptides that are located at subunit interfaces. Peptide binding is thought to allosterically alter the active site, decreasing GDP affinity, promoting GDP release, and increasing GTP affinity to facilitate GTP rebinding. {ECO:0000250|UniProtKB:P47122}.
uniprot
proteins
amino_acid_sequence
MAASAAAAELQASGGPRHPVCLLVLGMAGSGKTTFVQRLTGHLHAQGTPPYVINLDPAVHEVPFPANIDIRDTVKYKEVMKQYGLGPNGGIVTSLNLFATRFDQVMKFIEKAQNMSKYVLIDTPGQIEVFTWSASGTIITEALASSFPTVVIYVMDTSRSTNPVTFMSNMLYACSILYKTKLPFIVVMNKTDIIDHSFAVEWMQDFEAFQDALNQETTYVSNLTRSMSLVLDEFYSSLRVVGVSAVLGTGLDELFVQVTSAAEEYEREYRPEYERLKKSLANAESQQQREQLERLRKDMGSVALDAGTAKDSLSPVLHPSDLILTRGTLDEEDEEADSDTDDIDHRVTEESHEEPAFQNFMQESMAQYWKRNNK
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Small GTPase involved in the correct assembly of RNA polymerase II (RNAPII) complex, ensuring proper nuclear import of RNAPII (PubMed:11058119, PubMed:20855544, PubMed:21768307, PubMed:28153773). In vitro, exhibits a chaperone-like activity and a chaperone substrate protein can stimulate its GTPase activity. It is proposed to bind exposed hydrophobic peptide regions of newly synthesized RNAP II subunit, triggering the opening of a hydrophobic pocket in its GDP-bound state. This interaction likely traps exposed hydrophobic regions, preventing misassembly and providing a time window for association with the cognate RNAP II subunit. Peptide binding promotes GDP release, and increasing GTP affinity to facilitate GTP rebinding. Subsequent GTP hydrolysis would then lead to the release of the bound RNAP II subunit to enable association with cognate subunits and RNAP II assembly (By similarity). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). {ECO:0000250|UniProtKB:P47122, ECO:0000269|PubMed:11058119, ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:20855544, ECO:0000269|PubMed:21768307, ECO:0000269|PubMed:28153773}.
uniprot
proteins
mass_dalton
41740
uniprot
proteins
mutagenesis
MUTAGEN 29..32; /note="GSGK->AAAA: Abolishes GTPase activity and decreases association with GPN3."; /evidence="ECO:0000269|PubMed:21768307
uniprot
proteins
protein_family
GPN-loop GTPase family
uniprot
proteins
pubmed
11058119
uniprot
proteins
pubmed
11124703
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17643375
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20855544
uniprot
proteins
pubmed
20864038
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21768307
uniprot
proteins
pubmed
21844196
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25241168
uniprot
proteins
pubmed
28153773
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11058119, ECO:0000269|PubMed:20855544, ECO:0000269|PubMed:25241168}. Nucleus {ECO:0000269|PubMed:20855544, ECO:0000269|PubMed:25241168}. Note=Shuttles with GPN3 between the nucleus and the cytoplasm. {ECO:0000269|PubMed:20855544, ECO:0000269|PubMed:25241168}.
uniprot
proteins