Ncaph2
entrez
52683
canonical
uniprot
Q8BSP2
canonical
ensembl
ENSMUSG00000008690
resolver
ensp
ENSMUSP00000036900
resolver
ensp
ENSMUSP00000074139
resolver
ensp
ENSMUSP00000086095
resolver
ensp
ENSMUSP00000175831
resolver
enst
ENSMUST00000036987
resolver
genesymbol
Ncaph2
resolver
genesymbol_syn
D15Ertd785e
resolver
uniprot
E9PY48
resolver
uniprot
Q3TNI4
resolver
uniprot
Q8C2N3
resolver
uniprot
Q8C3K9
resolver
uniprot
Q8C4X8
resolver
uniprot
Q8CAZ3
resolver
uniprot
Q99L21
resolver
uniprot
Q9CT99
resolver
uniprot_entry
CNDH2_MOUSE
resolver
uniprot_entry
E9PY48_MOUSE
resolver
uniprot_sec
Q3TNI4
resolver
uniprot_sec
Q8C2N3
resolver
uniprot_sec
Q8C3K9
resolver
uniprot_sec
Q8C4X8
resolver
uniprot_sec
Q8CAZ3
resolver
uniprot_sec
Q99L21
resolver
uniprot_sec
Q9CT99
resolver
amino_acid_sequence
MEDVEVRFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKVEYLYSLVYQALDFISGKRRAKQLSLVQEDGSKKTVNSETPCETENEFLSLDDFPDSRANVDLKNDQASSELLIIPLLPMALVAPDEVEKNSSPLYSCQGDILASRKDFRMNTCMPNPRGCFMLDPVGMCPVEPVVPVEPYPMSRSQKDPEDAEEQPMEVSRNGSPVPVPDISQEPDGPALSGGEEDAEDGAEPLEVALEPAEPRTSQQSAILPRRYMLRERQGAPEPASRLQETPDPWQSLDPFDSLESKVFQKGKPYSVPPGVEEAPGQKRKRKGATKLQDFHKWYLDAYAEHPDGRRARRKGPTFADMEVLYWKHVKEQLETLQKLRRRKINERWLPGAKQDLWPTEEDRLEESLEDLGVADDFLEPEEYVEEPAGVMPEEAADLDAEAMPESLRYEELVRRNVELFIATSQKFIQETELSQRIRDWEDTIQPLLQEQEQHVPFDIHIYGDQLASRFPQLNEWCPFSELVAGQPAFEVCRSMLASLQLANDYTVEITQQPGLEAAVDTMSLRLLTHQRAHTRFQTYAAPSMAQP
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Ncaph2 are the cause of the nessy phenotype which is characterized by a specific defect in T-cell development. Nessy thymuses are smaller, with corticomedullary junctions less well defined, and cortical cells sparser than in wild-type. The thymocyte defect is typified by an increased proportion of CD4-CD8- DN T-cell progenitors. Only thymocyte differentiation is affected in Nessy mice and not cell differentiation.
uniprot
proteins
function
FUNCTION: Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (By similarity). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). Seems to have lineage-specific role in T-cell development (By similarity). {ECO:0000250|UniProtKB:Q6IBW4, ECO:0000269|PubMed:27737959}.
uniprot
proteins
mass_dalton
68945
uniprot
proteins
protein_family
CND2 H2 (condensin-2 subunit 2) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17640884
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27737959
uniprot
proteins
sequence_length
607
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins