Asb7
entrez
117589
canonical
uniprot
Q91ZU0
canonical
ensembl
ENSMUSG00000030509
resolver
ensp
ENSMUSP00000122395
resolver
ensp
ENSMUSP00000170896
resolver
enst
ENSMUST00000124899
resolver
genesymbol
Asb7
resolver
uniprot
C0H5Y0
resolver
uniprot
G3UVX4
resolver
uniprot_entry
ASB7_MOUSE
resolver
uniprot_entry
C0H5Y0_MOUSE
resolver
uniprot_sec
G3UVX4
resolver
amino_acid_sequence
MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQDVTRQPRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDDI
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as LZTS1, PSRC1 and SUV39H1 (By similarity). The ECS(ASB7) complex acts as a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1: ASB7 is recruited to heterochromatin by CBX5 (HP1 alpha), where it associates with SUV39H1, promoting the ubiquitin-proteasome-mediated degradation of SUV39H1 (By similarity). During mitosis, ASB7 is phosphorylated and inactivated, allowing SUV39H1 activity (By similarity). The ECS(ASB7) complex also plays a role in spindle dynamics and genome integrity by targeting the mitotic progression protein PSRC1 for proteasomal degradation in a cell cycle-dependent manner (By similarity). Also participates in meiosis by mediating the proper attachment between kinetochores and microtubules (PubMed:33251222). {ECO:0000250|UniProtKB:Q9H672, ECO:0000269|PubMed:33251222}.
uniprot
proteins
mass_dalton
35984
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9H672}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK1 during mitosis, preventing its association with SUV39H1 substrate. {ECO:0000250|UniProtKB:Q9H672}.
uniprot
proteins
protein_family
Ankyrin SOCS box (ASB) family
uniprot
proteins
pubmed
11509662
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
33251222
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:33251222}. Nucleus {ECO:0000269|PubMed:33251222}. Note=Localizes to heterochromatin; recruited to heterochromatin by CBX5 (HP1 alpha) (By similarity). Mainly localizes to the nucleus of oocytes; with the resumption of meiosis, colocalizes with the chromosomes from pre-metaphase I to metaphase II stage (PubMed:33251222). {ECO:0000250|UniProtKB:Q9H672, ECO:0000269|PubMed:33251222}.
uniprot
proteins