A1CF
entrez
29974
canonical
uniprot
Q9NQ94
canonical
ensembl
ENSG00000148584
resolver
ensp
ENSP00000363105
resolver
ensp
ENSP00000363107
resolver
ensp
ENSP00000363109
resolver
ensp
ENSP00000363113
resolver
ensp
ENSP00000378868
resolver
ensp
ENSP00000378873
resolver
ensp
ENSP00000397953
resolver
ensp
ENSP00000525080
resolver
ensp
ENSP00000525084
resolver
ensp
ENSP00000525086
resolver
enst
ENST00000395489
resolver
genesymbol
A1CF
resolver
genesymbol_syn
ACF
resolver
genesymbol_syn
ASP
resolver
hgnc
HGNC:24086
resolver
uniprot
A1L4F2
resolver
uniprot
A8K7G7
resolver
uniprot
B4E1E3
resolver
uniprot
B7ZM14
resolver
uniprot
F8W9F8
resolver
uniprot
Q5SZQ0
resolver
uniprot
Q9NQ93
resolver
uniprot
Q9NQX8
resolver
uniprot
Q9NQX9
resolver
uniprot
Q9NXC9
resolver
uniprot
Q9NZD3
resolver
uniprot_entry
A1CF_HUMAN
resolver
uniprot_entry
B4E1E3_HUMAN
resolver
uniprot_entry
F8W9F8_HUMAN
resolver
uniprot_sec
A1L4F2
resolver
uniprot_sec
A8K7G7
resolver
uniprot_sec
B7ZM14
resolver
uniprot_sec
Q5SZQ0
resolver
uniprot_sec
Q9NQ93
resolver
uniprot_sec
Q9NQX8
resolver
uniprot_sec
Q9NQX9
resolver
uniprot_sec
Q9NXC9
resolver
uniprot_sec
Q9NZD3
resolver
amino_acid_sequence
MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDAAPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKVEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRKLLPGRIQLWGHGIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNNIKPGAVERVKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRGTMLQGEYTYSLGQVYDPTTTYLGAPVFYAPQTYAAIPSLHFPATKGHLSNRAIIRAPSVREIYMNVPVGAAGVRGLGGRGYLAYTGLGRGYQVKGDKREDKLYDILPGMELTPMNPVTLKPQGIKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKITIPALASQNPAIHPFTPPKLSAFVDEAKTYAAEYTLQTLGIPTDGGDGTMATAAAAATAFPGYAVPNATAPVSAAQLKQAVTLGQDLAAYTTYEVYPTFAVTARGDGYGTF
uniprot
proteins
function
FUNCTION: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. {ECO:0000269|PubMed:10669759, ECO:0000269|PubMed:10781591, ECO:0000269|PubMed:12881431, ECO:0000269|PubMed:24916387}.
uniprot
proteins
mass_dalton
65202
uniprot
proteins
mutagenesis
MUTAGEN 59; /note="F->A: Greatly reduced RNA binding."; /evidence="ECO:0000269|PubMed:11871661"; MUTAGEN 100; /note="F->A: Greatly reduced RNA binding."; /evidence="ECO:0000269|PubMed:11871661"; MUTAGEN 139; /note="F->A: Greatly reduced RNA binding."; /evidence="ECO:0000269|PubMed:11871661"; MUTAGEN 183; /note="F->A: Greatly reduced RNA binding."; /evidence="ECO:0000269|PubMed:11871661"; MUTAGEN 234; /note="Y->A: Slightly reduced RNA binding."; /evidence="ECO:0000269|PubMed:11871661"; MUTAGEN 270; /note="F->A: Slightly reduced RNA binding."; /evidence="ECO:0000269|PubMed:11871661
uniprot
proteins
pubmed
10669759
uniprot
proteins
pubmed
10781591
uniprot
proteins
pubmed
11134005
uniprot
proteins
pubmed
11577082
uniprot
proteins
pubmed
11718896
uniprot
proteins
pubmed
11871661
uniprot
proteins
pubmed
12881431
uniprot
proteins
pubmed
12896982
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24916387
uniprot
proteins
sequence_length
594
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12881431, ECO:0000269|PubMed:24916387}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:12881431}. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. {ECO:0000250}.
uniprot
proteins