PYGL
entrez
5836
canonical
uniprot
P06737
canonical
ensembl
ENSG00000100504
resolver
ensp
ENSP00000216392
resolver
ensp
ENSP00000443787
resolver
genesymbol
PYGL
resolver
hgnc
HGNC:9725
resolver
uniprot
A6NDQ4
resolver
uniprot
B4DUB7
resolver
uniprot
F5H816
resolver
uniprot
O60567
resolver
uniprot
O60752
resolver
uniprot
O60913
resolver
uniprot
Q501V9
resolver
uniprot
Q641R5
resolver
uniprot
Q96G82
resolver
uniprot_entry
PYGL_HUMAN
resolver
uniprot_sec
A6NDQ4
resolver
uniprot_sec
B4DUB7
resolver
uniprot_sec
F5H816
resolver
uniprot_sec
O60567
resolver
uniprot_sec
O60752
resolver
uniprot_sec
O60913
resolver
uniprot_sec
Q501V9
resolver
uniprot_sec
Q641R5
resolver
uniprot_sec
Q96G82
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically regulated through the non-covalent binding of metabolites, being activated by AMP and inhibited by ATP, ADP, and glucose-6-phosphate. The activity is also controlled by post-translational modifications including phosphorylation and acetylation. {ECO:0000269|PubMed:22225877}.
uniprot
proteins
amino_acid_sequence
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNESNKVNGN
uniprot
proteins
disease_involvement
DISEASE: Glycogen storage disease 6 (GSD6) [MIM:232700]: A metabolic disorder characterized by mild to moderate hypoglycemia, mild ketosis, growth retardation, and prominent hepatomegaly. Heart and skeletal muscle are not affected. {ECO:0000269|PubMed:9529348}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.4.1.1
uniprot
proteins
function
FUNCTION: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. {ECO:0000269|PubMed:22225877}.
uniprot
proteins
mass_dalton
97149
uniprot
proteins
mutagenesis
MUTAGEN 470; /note="K->Q: Decreased glycogen phosphorylase activity."; /evidence="ECO:0000269|PubMed:22225877"; MUTAGEN 470; /note="K->R: Decreased acetylation; when associated with R-796."; /evidence="ECO:0000269|PubMed:22225877"; MUTAGEN 796; /note="K->Q: Decreased glycogen phosphorylase activity."; /evidence="ECO:0000269|PubMed:22225877"; MUTAGEN 796; /note="K->R: Decreased acetylation; when associated with R-470."; /evidence="ECO:0000269|PubMed:22225877
uniprot
proteins
post_translational_modification
PTM: Acetylation, which is up-regulated by glucose and insulin and down-regulated by glucagon, inhibits the glycogen phosphorylase activity by promoting PPP1R3B-mediated recruitment of phosphatase PP1 and Ser-15 dephosphorylation. {ECO:0000269|PubMed:22225877}.; PTM: Phosphorylation at Ser-15 converts inactive phosphorylase b into active phosphorylase a (PubMed:10949035). Dephosphorylation of Ser-15 by phosphatase PP1 inactivates the enzyme (PubMed:22225877). {ECO:0000269|PubMed:10949035, ECO:0000269|PubMed:22225877}.
uniprot
proteins
protein_family
Glycogen phosphorylase family
uniprot
proteins
pubmed
10949035
uniprot
proteins
pubmed
10980448
uniprot
proteins
pubmed
12204691
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22225877
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2877458
uniprot
proteins
pubmed
3509980
uniprot
proteins
pubmed
9529348
uniprot
proteins
pubmed
9536091
uniprot
proteins
sequence_length
847
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:22225877}.
uniprot
proteins