Setd7
entrez
73251
canonical
uniprot
Q8VHL1
canonical
ensembl
ENSMUSG00000037111
resolver
ensp
ENSMUSP00000043492
resolver
enst
ENSMUST00000037141
resolver
genesymbol
Setd7
resolver
genesymbol_syn
Kiaa1717
resolver
genesymbol_syn
Set7
resolver
genesymbol_syn
Set9
resolver
uniprot
Q6ZPJ6
resolver
uniprot
Q80UU3
resolver
uniprot
Q8C7Y6
resolver
uniprot_entry
SETD7_MOUSE
resolver
uniprot_sec
Q6ZPJ6
resolver
uniprot_sec
Q80UU3
resolver
uniprot_sec
Q8C7Y6
resolver
amino_acid_sequence
MDSDDEVVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDSDGRLIFKGQYKDNNRHGVCWIHYPDGGSLVGEVNEDGEMTGEKIAYVYPDQRTALYGKFIDGEMLEGKLATLMATEEGRPHFEVTSGSSVYHFDKSTSSCISSDALLPDPYESERVYVADSLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCVYDLFVHPRFGPIKCIRTLRAVEAEEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK
uniprot
proteins
ec_number
2.1.1.364
uniprot
proteins
function
FUNCTION: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (By similarity). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:12711597). Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (By similarity). Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed:35210392). Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (By similarity). Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (By similarity). Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (PubMed:35210392). Acts as a positive regulator of smoothened signaling by mediating methylation of full-length GLI3, increasing GLI3 ability to bind DNA (By similarity). {ECO:0000250|UniProtKB:Q8WTS6, ECO:0000269|PubMed:12711597, ECO:0000269|PubMed:35210392}.
uniprot
proteins
mass_dalton
40506
uniprot
proteins
mutagenesis
MUTAGEN 297; /note="H->A: Abolishes methyltransferase activity."; /evidence="ECO:0000269|PubMed:35210392
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
protein_family
SET7 subfamily
uniprot
proteins
pubmed
11779497
uniprot
proteins
pubmed
12711597
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15975555
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
35210392
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WTS6}. Chromosome {ECO:0000250|UniProtKB:Q8WTS6}.
uniprot
proteins