Tafazzin
entrez
66826
canonical
uniprot
Q91WF0
canonical
ensembl
ENSMUSG00000009995
resolver
ensp
ENSMUSP00000065270
resolver
ensp
ENSMUSP00000109818
resolver
ensp
ENSMUSP00000134745
resolver
ensp
ENSMUSP00000135308
resolver
ensp
ENSMUSP00000135593
resolver
ensp
ENSMUSP00000294303
resolver
ensp
ENSMUSP00000294311
resolver
ensp
ENSMUSP00000294317
resolver
ensp
ENSMUSP00000294318
resolver
ensp
ENSMUSP00000294323
resolver
ensp
ENSMUSP00000294324
resolver
ensp
ENSMUSP00000363095
resolver
enst
ENSMUST00000114180
resolver
enst
ENSMUST00000132437
resolver
genesymbol
Tafazzin
resolver
genesymbol_syn
TAZ
resolver
genesymbol_syn
Taz
resolver
uniprot
H3BK99
resolver
uniprot
I7HJS2
resolver
uniprot
Q810E8
resolver
uniprot_entry
H3BK99_MOUSE
resolver
uniprot_entry
I7HJS2_MOUSE
resolver
uniprot_entry
TAZ_MOUSE
resolver
uniprot_sec
Q810E8
resolver
amino_acid_sequence
MPLHVKWPFPAVPRLTWTLASSVVMGLVGTYSCFWTKYMNHLTVHNKEVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGDGVYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSTLPVLERLRAENKSAVEMRKALTDFIQEEFQRLKMQAEQLHNHFQPGR
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
function
FUNCTION: Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function (PubMed:19114128, PubMed:21068380, PubMed:21091282, PubMed:23130124, PubMed:26114544, PubMed:30055293, PubMed:30389594). Its role in cellular physiology is to improve mitochondrial performance (By similarity). CL is critical for the coassembly of lipids and proteins in mitochondrial membranes, for instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (By similarity). Catalyzes the transacylation between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL. Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations. Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate. Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution. Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor. CoA-independent, it can reshuffle molecular species within a single phospholipid class. Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL. Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane. Hence, by contributing to the flexibility of the lipid composition, it plays an important role in the dynamics of mitochondria membranes. Essential for the final stage of spermatogenesis, spermatid individualization (By similarity). Required for the initiation of mitophagy (PubMed:25919711). Required to ensure progression of spermatocytes through meiosis (PubMed:26114544). {ECO:0000250|UniProtKB:Q06510, ECO:0000250|UniProtKB:Q16635, ECO:0000250|UniProtKB:Q9V6G5, ECO:0000269|PubMed:19114128, ECO:0000269|PubMed:21068380, ECO:0000269|PubMed:21091282, ECO:0000269|PubMed:23130124, ECO:0000269|PubMed:25919711, ECO:0000269|PubMed:26114544, ECO:0000269|PubMed:30055293, ECO:0000269|PubMed:30389594}.
uniprot
proteins
mass_dalton
30334
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism. {ECO:0000250|UniProtKB:Q16635}.
uniprot
proteins
protein_family
Taffazin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15499385
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19114128
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21068380
uniprot
proteins
pubmed
21091282
uniprot
proteins
pubmed
23130124
uniprot
proteins
pubmed
23616771
uniprot
proteins
pubmed
25919711
uniprot
proteins
pubmed
26114544
uniprot
proteins
pubmed
30055293
uniprot
proteins
pubmed
30389594
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q16635}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q16635}; Intermembrane side {ECO:0000250|UniProtKB:Q16635}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q16635}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q16635}; Intermembrane side {ECO:0000250|UniProtKB:Q16635}.
uniprot
proteins