PRKAB1
entrez
5564
canonical
uniprot
Q9Y478
canonical
ensembl
ENSG00000111725
resolver
ensp
ENSP00000229328
resolver
ensp
ENSP00000441369
resolver
enst
ENST00000229328
resolver
enst
ENST00000541640
resolver
genesymbol
PRKAB1
resolver
genesymbol_syn
AMPK
resolver
hgnc
HGNC:9378
resolver
uniprot
Q9UBV0
resolver
uniprot
Q9UE20
resolver
uniprot
Q9UEX2
resolver
uniprot
Q9Y6V8
resolver
uniprot_entry
AAKB1_HUMAN
resolver
uniprot_sec
Q9UBV0
resolver
uniprot_sec
Q9UE20
resolver
uniprot_sec
Q9UEX2
resolver
uniprot_sec
Q9Y6V8
resolver
amino_acid_sequence
MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
uniprot
proteins
mass_dalton
30382
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Abolishes myristoylation and AMP-enhanced phosphorylation of PRKAA1 or PRKAA2."; /evidence="ECO:0000269|PubMed:21680840
uniprot
proteins
post_translational_modification
PTM: Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK. {ECO:0000269|PubMed:21460634}.
uniprot
proteins
protein_family
5'-AMP-activated protein kinase beta subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17028174
uniprot
proteins
pubmed
17307971
uniprot
proteins
pubmed
17712357
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18403135
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21460634
uniprot
proteins
pubmed
21680840
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9224708
uniprot
proteins
sequence_length
270
uniprot
proteins