GPR19
entrez
2842
canonical
uniprot
Q15760
canonical
ensembl
ENSG00000183150
resolver
ensp
ENSP00000333744
resolver
ensp
ENSP00000441832
resolver
ensp
ENSP00000498976
resolver
ensp
ENSP00000529114
resolver
ensp
ENSP00000529115
resolver
ensp
ENSP00000529116
resolver
ensp
ENSP00000529117
resolver
ensp
ENSP00000582593
resolver
ensp
ENSP00000582594
resolver
ensp
ENSP00000582595
resolver
ensp
ENSP00000582596
resolver
enst
ENST00000332427
resolver
enst
ENST00000540510
resolver
enst
ENST00000651487
resolver
enst
ENST00000859055
resolver
enst
ENST00000859056
resolver
enst
ENST00000859057
resolver
enst
ENST00000859058
resolver
enst
ENST00000912534
resolver
enst
ENST00000912535
resolver
enst
ENST00000912536
resolver
enst
ENST00000912537
resolver
genesymbol
GPR19
resolver
hgnc
HGNC:4473
resolver
uniprot
Q6IBH2
resolver
uniprot_entry
GPR19_HUMAN
resolver
uniprot_entry
Q6IBH2_HUMAN
resolver
amino_acid_sequence
MVFAHRMDNSKPHLIIPTLLVPLQNRSCTETATPLPSQYLMELSEEHSWMSNQTDLHYVLKPGEVATASIFFGILWLFSIFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLISVASTPFVLLQFTTGRWTLGSATCKVVRYFQYLTPGVQIYVLLSICIDRFYTIVYPLSFKVSREKAKKMIAASWVFDAGFVTPVLFFYGSNWDSHCNYFLPSSWEGTAYTVIHFLVGFVIPSVLIILFYQKVIKYIWRIGTDGRTVRRTMNIVPRTKVKTIKMFLILNLLFLLSWLPFHVAQLWHPHEQDYKKSSLVFTAITWISFSSSASKPTLYSIYNANFRRGMKETFCMSSMKCYRSNAYTITTSSRMAKKNYVGISEIPSMAKTITKDSIYDSFDREAKEKKLAWPINSNPPNTFV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that plays a role in the regulation of circadian rhythms and energy metabolism. Participates in maintaining proper circadian gene expression in the suprachiasmatic nucleus (SCN), the locus of the master circadian clock in the brain (By similarity). May function as a coordinator of aging-associated metabolic dysfunction, stress response, DNA integrity management, and eventual senescence (PubMed:37239845). Upon binding to adropin, modulates mitochondrial energy metabolism via the p44/42-PDK4 signaling pathway, influencing pyruvate dehydrogenase activity (By similarity). {ECO:0000250|UniProtKB:P70585, ECO:0000250|UniProtKB:Q61121, ECO:0000269|PubMed:37239845}.
uniprot
proteins
mass_dalton
47687
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
37239845
uniprot
proteins
pubmed
37923782
uniprot
proteins
pubmed
8830667
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37923782}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 70..90; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 144..161; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 222..242; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 278..298; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 310..325; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins