SULT2A1
entrez
6822
canonical
uniprot
Q06520
canonical
ensembl
ENSG00000105398
resolver
ensp
ENSP00000222002
resolver
enst
ENST00000222002
resolver
genesymbol
SULT2A1
resolver
genesymbol_syn
HST
resolver
genesymbol_syn
STD
resolver
hgnc
HGNC:11458
resolver
uniprot
A8K015
resolver
uniprot_entry
A8K015_HUMAN
resolver
uniprot_entry
ST2A1_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Subject to substrate inhibition. Alternate orientations for binding of steroid substrates to SULT2A1 may play a role in substrate inhibition. {ECO:0000269|PubMed:18042734}.
uniprot
proteins
amino_acid_sequence
MSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSKGDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLMRNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFLLLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVVDKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRELFPWE
uniprot
proteins
ec_number
2.8.2.14
uniprot
proteins
ec_number
2.8.2.2
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed:14573603, PubMed:18042734, PubMed:19589875, PubMed:20102295, PubMed:21187059, PubMed:2268288, PubMed:29671343, PubMed:7678732, PubMed:7854148). Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups (PubMed:14573603, PubMed:18042734, PubMed:19589875, PubMed:20102295, PubMed:21187059, PubMed:2268288, PubMed:29671343, PubMed:7678732, PubMed:7854148). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis (PubMed:14573603, PubMed:19589875, PubMed:21187059). Plays a key role in bile acid metabolism, mediating formation of 3-sulfated bile acids (PubMed:2268288, PubMed:20102295). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity). {ECO:0000250|UniProtKB:P15709, ECO:0000269|PubMed:14573603, ECO:0000269|PubMed:18042734, ECO:0000269|PubMed:19589875, ECO:0000269|PubMed:20102295, ECO:0000269|PubMed:21187059, ECO:0000269|PubMed:2268288, ECO:0000269|PubMed:29671343, ECO:0000269|PubMed:7678732, ECO:0000269|PubMed:7854148}.
uniprot
proteins
mass_dalton
33780
uniprot
proteins
mutagenesis
MUTAGEN 137; /note="M->I: Strongly reduces substrate inhibition when ADT or DHEA are used as substrates."; /evidence="ECO:0000269|PubMed:18042734"; MUTAGEN 137; /note="M->W: Substrate inhibition is completely eliminated for DHEA; when associated with A-238."; /evidence="ECO:0000269|PubMed:18042734"; MUTAGEN 238; /note="Y->A: Completely eliminates the substrate inhibition when ADT is used as substrate. Partially eliminates substrate inhibition when DHEA is used as substrate. Completely eliminates the substrate inhibition for DHEA, when associated with I-137."; /evidence="ECO:0000269|PubMed:18042734"; MUTAGEN 238; /note="Y->F: Strongly reduces substrate inhibition when ADT or DHEA are used as substrates."; /evidence="ECO:0000269|PubMed:18042734"; MUTAGEN 238; /note="Y->W: Strongly reduces substrate inhibition when ADT or DHEA are used as substrates."; /evidence="ECO:0000269|PubMed:18042734
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
10854859
uniprot
proteins
pubmed
11988089
uniprot
proteins
pubmed
14573603
uniprot
proteins
pubmed
1520333
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1588921
uniprot
proteins
pubmed
18042734
uniprot
proteins
pubmed
19589875
uniprot
proteins
pubmed
20102295
uniprot
proteins
pubmed
21187059
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2268288
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29671343
uniprot
proteins
pubmed
7589785
uniprot
proteins
pubmed
7598806
uniprot
proteins
pubmed
7678732
uniprot
proteins
pubmed
7710689
uniprot
proteins
pubmed
7854148
uniprot
proteins
sequence_length
285
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:2268288}.
uniprot
proteins