Btbd1
entrez
83962
canonical
uniprot
P58544
canonical
ensembl
ENSMUSG00000025103
resolver
ensp
ENSMUSP00000026093
resolver
ensp
ENSMUSP00000315769
resolver
enst
ENSMUST00000026093
resolver
genesymbol
Btbd1
resolver
genesymbol_syn
Gsrp
resolver
uniprot
Q6GQU7
resolver
uniprot
Q8BTZ0
resolver
uniprot
Q8K0J0
resolver
uniprot_entry
BTBD1_MOUSE
resolver
uniprot_sec
Q6GQU7
resolver
uniprot_sec
Q8BTZ0
resolver
uniprot_sec
Q8K0J0
resolver
amino_acid_sequence
MASLGSAAAGEPATGAEAEPGPPAPPPPPPPPPAPSPSALGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTVDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAIVRWAEAECQRQQLAVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIRFTVNRRISVVGFGLYGSIHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFKEPIEILPNVCYTACATLKGPDSHYGTKGLKKVVHETPAASKTVFLFFSSPGNNNGTSIEDGQIPEIIFYT
uniprot
proteins
function
FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (PubMed:15486563, PubMed:17462629). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (PubMed:15486563, PubMed:17462629). {ECO:0000250|UniProtKB:Q9H0C5, ECO:0000269|PubMed:15486563, ECO:0000269|PubMed:17462629}.
uniprot
proteins
mass_dalton
53233
uniprot
proteins
mutagenesis
MUTAGEN 1..108; /note="Missing: Fails to induce myogenic differentiation in C2C12 cells."; /evidence="ECO:0000269|PubMed:15486563
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
15486563
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17462629
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15486563}. Note=Localizes to punctate or elongated cytoplasmic bodies. {ECO:0000250|UniProtKB:Q9H0C5}.
uniprot
proteins