Kcnd2
entrez
16508
canonical
uniprot
Q9Z0V2
canonical
ensembl
ENSMUSG00000060882
resolver
ensp
ENSMUSP00000080257
resolver
enst
ENSMUST00000081542
resolver
genesymbol
Kcnd2
resolver
genesymbol_syn
Kiaa1044
resolver
uniprot
Q8BSK3
resolver
uniprot
Q8CHB7
resolver
uniprot
Q9JJ60
resolver
uniprot_entry
KCND2_MOUSE
resolver
uniprot_sec
Q8BSK3
resolver
uniprot_sec
Q8CHB7
resolver
uniprot_sec
Q9JJ60
resolver
amino_acid_sequence
MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDNTGESALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEPAFISKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRIPNANVSGSHRGSVQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISIPTPPVTTPEGDDRPESPEYSGGNIVRVSAL
uniprot
proteins
function
FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in rodent heart. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (PubMed:10818150, PubMed:17122039, PubMed:18045912, PubMed:18187474, PubMed:20371829, PubMed:22815518). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites (PubMed:10818150, PubMed:17122039, PubMed:22815518). Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (PubMed:22815518). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (PubMed:18045912). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member (PubMed:10601491, PubMed:11909823, PubMed:23713033, PubMed:9734479). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:22311982, PubMed:9734479). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel (PubMed:11909823). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes (PubMed:11909823). Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (By similarity). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (PubMed:22311982). Upon depolarization, the channel goes from a resting closed state (C state) to an activated but non-conducting state (C* state), from there, the channel may either inactivate (I state) or open (O state) (By similarity). {ECO:0000250|UniProtKB:Q63881, ECO:0000250|UniProtKB:Q9NZV8, ECO:0000269|PubMed:10601491, ECO:0000269|PubMed:10818150, ECO:0000269|PubMed:11909823, ECO:0000269|PubMed:17122039, ECO:0000269|PubMed:18187474, ECO:0000269|PubMed:20371829, ECO:0000269|PubMed:22311982, ECO:0000269|PubMed:23713033, ECO:0000269|PubMed:9734479}.
uniprot
proteins
mass_dalton
70577
uniprot
proteins
mutagenesis
MUTAGEN 362; /note="W->F: Abolishes channel activity. Alters potassium channel kinetics in heart myocytes. Abolishes the fast component of I(to) in heart ventricle."; /evidence="ECO:0000269|PubMed:10601491, ECO:0000269|PubMed:9734479"; MUTAGEN 602; /note="T->A: No effect on the regulation of neuronal A-type current in response to activation of metabotropic glutamate receptors."; /evidence="ECO:0000269|PubMed:18045912"; MUTAGEN 607; /note="T->A: No effect on the regulation of neuronal A-type current in response to activation of metabotropic glutamate receptors."; /evidence="ECO:0000269|PubMed:18045912"; MUTAGEN 616; /note="S->A: Abolishes regulation of neuronal A-type current in response to activation of metabotropic glutamate receptors."; /evidence="ECO:0000269|PubMed:18045912
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-438 in response to MAPK activation is increased in stimulated dendrites. Interaction with KCNIP2 and DPP6 propomtes phosphorylation by PKA at Ser-552. Phosphorylation at Ser-552 has no effect on interaction with KCNIP3, but is required for the regulation of channel activity by KCNIP3. Phosphorylation at Ser-552 leads to KCND2 internalization (By similarity). Phosphorylated by MAPK in response to signaling via the metabotropic glutamate receptor GRM5 (PubMed:18045912). Phosphorylation at Ser-616 is required for the down-regulation of neuronal A-type currents in response to signaling via GRM5 (PubMed:18045912). {ECO:0000250|UniProtKB:Q63881, ECO:0000269|PubMed:18045912}.
uniprot
proteins
protein_family
D (Shal) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv4.2/KCND2 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10601491
uniprot
proteins
pubmed
10818150
uniprot
proteins
pubmed
11040264
uniprot
proteins
pubmed
11606724
uniprot
proteins
pubmed
11909823
uniprot
proteins
pubmed
12465718
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16009497
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16293790
uniprot
proteins
pubmed
17122039
uniprot
proteins
pubmed
17122053
uniprot
proteins
pubmed
17917103
uniprot
proteins
pubmed
18045912
uniprot
proteins
pubmed
18187474
uniprot
proteins
pubmed
18357523
uniprot
proteins
pubmed
19713751
uniprot
proteins
pubmed
20371829
uniprot
proteins
pubmed
20857488
uniprot
proteins
pubmed
20943905
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22098631
uniprot
proteins
pubmed
22311982
uniprot
proteins
pubmed
22612819
uniprot
proteins
pubmed
22738428
uniprot
proteins
pubmed
22815518
uniprot
proteins
pubmed
23713033
uniprot
proteins
pubmed
9734479
uniprot
proteins
sequence_length
630
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16009497, ECO:0000269|PubMed:17122053, ECO:0000269|PubMed:22098631, ECO:0000269|PubMed:22311982, ECO:0000269|PubMed:9734479}; Multi-pass membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000269|PubMed:11040264, ECO:0000269|PubMed:17122053, ECO:0000269|PubMed:22098631}. Synapse {ECO:0000269|PubMed:16009497, ECO:0000269|PubMed:17122053}. Perikaryon {ECO:0000269|PubMed:11040264, ECO:0000269|PubMed:16009497, ECO:0000269|PubMed:17122053, ECO:0000269|PubMed:22098631}. Postsynaptic cell membrane {ECO:0000269|PubMed:16009497}. Cell projection, dendritic spine {ECO:0000269|PubMed:17122053}. Cell junction {ECO:0000250|UniProtKB:Q63881}. Membrane, caveola {ECO:0000250|UniProtKB:Q63881}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q63881}. Note=In neurons, primarily detected on dendrites, dendritic spines and on the neuron cell body, but not on axons (PubMed:17122053, PubMed:22098631). Localized preferentially at the dendrites of pyramidal cells in the hippocampus CA1 layer. Detected at GABAergic synapses (PubMed:16009497). Detected at cell junctions that are distinct from synaptic cell contacts (By similarity). Detected in lipid rafts (By similarity). Detected primarily at the endoplasmic reticulum or Golgi when expressed by itself (By similarity). Interaction with KCNIP1, KCNIP2, KCNIP3 or KCNIP4 promotes expression at the cell membrane (PubMed:22311982). Interaction with DPP6 or DPP10 promotes expression at the cell membrane (By similarity). Internalized from the cell membrane by clathrin-dependent endocytosis in response to activation of AMPA-selective glutamate receptors and PKA-mediated phosphorylation at Ser-552. Redistributed from dendritic spines to the main dendritic shaft in response to activation of AMPA-selective glutamate receptors and activation of PKA (By similarity). {ECO:0000250|UniProtKB:Q63881, ECO:0000269|PubMed:17122053, ECO:0000269|PubMed:22098631, ECO:0000269|PubMed:22311982}.
uniprot
proteins
transmembrane_region
TRANSMEM 185..206; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:Q9NZV8"; TRANSMEM 227..249; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:Q9NZV8"; TRANSMEM 257..281; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:Q9NZV8"; TRANSMEM 288..307; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:Q9NZV8"; TRANSMEM 322..345; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:Q9NZV8"; TRANSMEM 381..403; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:Q9NZV8
uniprot
proteins