Cerk
entrez
223753
canonical
uniprot
Q8K4Q7
canonical
ensembl
ENSMUSG00000035891
resolver
ensp
ENSMUSP00000038203
resolver
ensp
ENSMUSP00000232155
resolver
ensp
ENSMUSP00000232169
resolver
enst
ENSMUST00000044332
resolver
genesymbol
Cerk
resolver
uniprot
Q52KP2
resolver
uniprot_entry
CERK1_MOUSE
resolver
uniprot_sec
Q52KP2
resolver
amino_acid_sequence
MGAMGAAEPLHSVLWVKRRRCAVSLEPARALLRWWRSPEPGPSAPGADARSVLVSEIIAVEEKDDCEKHASSGRWHKMENPFAFTVHRVKRVRHHRWKWARVTFWSADEQLCHLWLQTLRGLLESLTSRPKHLLVFINPFGGKGQGKRIYEKTVAPLFTLASITTEIIITEHANQAKETLYEINTDSYDGIVCVGGDGMFSEVLHGVIGRTQQSAGIDPNHPRAVLVPSTLRIGIIPAGSTDCVCYSTVGTNDAETSALHIIIGDSLAIDVSSVHYHNTLLRYSVSLLGYGFYGDLIKDSEKKRWMGLVRYDFSGLKTFLSHQYYEGTLSFLPAQHTVGSPRDNKPCRAGCFVCRQSKQQLEEEEKKALYGLENAEEMEEWQVTCGKFLAINATNMSCACPRSPGGLSPFAHLGDGSSDLILIRKCSRFNFLRFLIRHTNQEDQFDFTFVEVYRVKKFHFTSKHVEDEDNDSKEQEKQKFGKICKDRPSCTCSASRSSWNCDGEVMHSPAIEVRVHCQLVRLFARGIEEES
uniprot
proteins
ec_number
2.7.1.138
uniprot
proteins
function
FUNCTION: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:16269826). Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:16269826). Shows a greater preference for D-erythro isomer of ceramides (By similarity). Binds phosphoinositides (By similarity). {ECO:0000250|UniProtKB:Q8TCT0, ECO:0000269|PubMed:16269826}.
uniprot
proteins
mass_dalton
59843
uniprot
proteins
pubmed
11956206
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16269826
uniprot
proteins
sequence_length
531
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8TCT0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8TCT0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8TCT0}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8TCT0}.
uniprot
proteins