Ehd1
entrez
13660
canonical
uniprot
Q9WVK4
canonical
ensembl
ENSMUSG00000024772
resolver
ensp
ENSMUSP00000025684
resolver
enst
ENSMUST00000025684
resolver
genesymbol
Ehd1
resolver
genesymbol_syn
Past1
resolver
uniprot
Q7TPR6
resolver
uniprot
Q80ZZ0
resolver
uniprot_entry
EHD1_MOUSE
resolver
uniprot_entry
Q80ZZ0_MOUSE
resolver
uniprot_sec
Q7TPR6
resolver
amino_acid_sequence
MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISSGDFPSLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQAVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLIPPSKRRHE
uniprot
proteins
function
FUNCTION: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (By similarity). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15930129, PubMed:20159556). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (PubMed:21177873). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (PubMed:24373286). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (By similarity). {ECO:0000250|UniProtKB:Q641Z6, ECO:0000250|UniProtKB:Q9H4M9, ECO:0000269|PubMed:15930129, ECO:0000269|PubMed:20159556, ECO:0000269|PubMed:21177873, ECO:0000269|PubMed:24373286}.
uniprot
proteins
mass_dalton
60603
uniprot
proteins
mutagenesis
MUTAGEN 65; /note="G->R: Abolishes interaction with PACSIN2."; /evidence="ECO:0000269|PubMed:15930129"; MUTAGEN 485; /note="W->A: Abolishes interaction with PACSIN2."; /evidence="ECO:0000269|PubMed:15930129
uniprot
proteins
protein_family
Dynamin/Fzo/YdjA family
uniprot
proteins
protein_family
EHD subfamily
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
10395801
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15930129
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20159556
uniprot
proteins
pubmed
21177873
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23572513
uniprot
proteins
pubmed
24373286
uniprot
proteins
sequence_length
534
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:Q9H4M9}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome membrane {ECO:0000250|UniProtKB:Q9H4M9}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:21177873}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:24373286}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q9H4M9}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Preferentially associates with tubular recycling endosomes (By similarity). Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (PubMed:21177873). Localizes to the ciliary pocket from where the cilium protrudes (By similarity). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippocampal mossy fiber terminals. {ECO:0000250|UniProtKB:Q9H4M9, ECO:0000269|PubMed:21177873, ECO:0000269|PubMed:24373286}.
uniprot
proteins