Bdh2
entrez
295458
canonical
uniprot
D4A1J4
canonical
ensembl
ENSRNOG00000014490
resolver
ensp
ENSRNOP00000019507
resolver
enst
ENSRNOT00000019507
resolver
genesymbol
Bdh2
resolver
genesymbol_syn
Dhrs6
resolver
uniprot
A0A0A0MXX5
resolver
uniprot_entry
A0A0A0MXX5_RAT
resolver
uniprot_entry
DHRS6_RAT
resolver
amino_acid_sequence
MGRLEGKVIVLTAAAQGIGRASALAFAREGAKVIATDINEAKLQELENYPGIQTRVLDVTKKRQIDQFASEIEKIDVLFNVAGFVHHGTILDCEEKDWDFSMNLNVRSMYLMIKAFLPKMLAQKSGNIINMSSVASSIKGVENRCVYSATKAAVIGLTKSVAADFIQQGIRCNCVCPGTVDTPSLQERIQARDDPKEALKAFLNRQKTGRFASAEEVALLCVYLASDESAYVTGTPVVIDGGWSL
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
ec_number
1.1.1.104
uniprot
proteins
ec_number
1.1.1.30
uniprot
proteins
function
FUNCTION: NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (By similarity). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines (PubMed:35150746). Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (By similarity). May act as a 3-hydroxybutyrate dehydrogenase (By similarity). {ECO:0000250|UniProtKB:Q8JZV9, ECO:0000250|UniProtKB:Q9BUT1, ECO:0000269|PubMed:35150746}.
uniprot
proteins
mass_dalton
26651
uniprot
proteins
mutagenesis
MUTAGEN 147; /note="Y->F: Loss of function."; /evidence="ECO:0000269|PubMed:35150746
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid metabolism. {ECO:0000305|PubMed:35150746}.; PATHWAY: Siderophore biosynthesis. {ECO:0000250|UniProtKB:Q8JZV9}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
35150746
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BUT1}.
uniprot
proteins