GABRR1
entrez
2569
canonical
uniprot
P24046
canonical
ensembl
ENSG00000146276
resolver
ensp
ENSP00000358463
resolver
ensp
ENSP00000394687
resolver
ensp
ENSP00000412673
resolver
genesymbol
GABRR1
resolver
hgnc
HGNC:4090
resolver
uniprot
A1L401
resolver
uniprot
B4DJK8
resolver
uniprot
B4DQT5
resolver
uniprot
B7ZBQ7
resolver
uniprot
Q9BX06
resolver
uniprot_entry
GBRR1_HUMAN
resolver
uniprot_sec
A1L401
resolver
uniprot_sec
B4DJK8
resolver
uniprot_sec
B4DQT5
resolver
uniprot_sec
B7ZBQ7
resolver
uniprot_sec
Q9BX06
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by TPMPA, a rho-specific antagonist, when forming a homopentamer (PubMed:37659407). In contrast with other GABAARs, rho-1 GABAAR is not inhibited by bicuculline, when forming a homopentamer (PubMed:37659407). {ECO:0000269|PubMed:37659407}.
uniprot
proteins
amino_acid_sequence
MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
uniprot
proteins
function
FUNCTION: Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:37659407). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (PubMed:37659407). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:37659407). Rho-1 subunits are primarily expressed in retina where rho-1-containing GABAARs may play a role in retinal neurotransmission (PubMed:1849271). Rho-1 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (By similarity). Rho-1 GABAARs may also contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (By similarity). {ECO:0000250|UniProtKB:P56475, ECO:0000269|PubMed:1849271, ECO:0000269|PubMed:37659407}.
uniprot
proteins
mass_dalton
55883
uniprot
proteins
protein_family
GABRR1 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1849271
uniprot
proteins
pubmed
37659407
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P56475}; Multi-pass membrane protein {ECO:0000269|PubMed:37659407}. Cell membrane {ECO:0000269|PubMed:37659407}; Multi-pass membrane protein {ECO:0000269|PubMed:37659407}.
uniprot
proteins
transmembrane_region
TRANSMEM 281..301; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 314..334; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 346..366; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 458..478; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins