Mus81
entrez
71711
canonical
uniprot
Q91ZJ0
canonical
ensembl
ENSMUSG00000024906
resolver
ensp
ENSMUSP00000114895
resolver
enst
ENSMUST00000124334
resolver
genesymbol
Mus81
resolver
uniprot
Q8R356
resolver
uniprot_entry
MUS81_MOUSE
resolver
uniprot_sec
Q8R356
resolver
amino_acid_sequence
MAEPVRLGRKRPLPVCPNPLFVRWLTEWRDEAASRGRHTRFVFQKALRSLQRYPLPLRSGKEAKILQHFGDRLCRMLDEKLKQHLASGGDHAPSSPSGKKGASKGPPEQVQDSSMPVPTQPQAGSTSVGYWPAQNSGAREILLQLYREHLNSDGHSFLTKEELLQKCAQKTPRVVPGSSKPWPALRSLLHRNLILGTHRPARYALTPEGLELAQKLAEAEGLSTRHAGFRPEEHHGEDSAVPEALSEPGTTEGAVQQRPLELRPSEYRVLLCVDIGETRGAGHRPEMLRELQRLRVPHTVRKLHVGDFVWVAQETRPRDPERPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLGHRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTMDIKESAGYLALLTKGLERLYQGHTLRSRPWGAPGAAESEAKPSTNPLCSLLTFSDFNAEAVKNKAQSVREVFARQLMQVRGLSGEKAAAVVDRYSTPASLLAAYDACATAKEQEMLLSTIKCGRLQRNLGPALSRTLYQLYCSHSPLS
uniprot
proteins
ec_number
3.1.22.-
uniprot
proteins
function
FUNCTION: Catalytic subunit of two functionally distinct, structure-specific, heterodimeric DNA endonucleases MUS81-EME1 and MUS81-EME2 that are involved in the maintenance of genome stability (PubMed:14609959, PubMed:15205536, PubMed:16107704). Both endonucleases have essentially the same substrate specificity though MUS81-EME2 is more active than its MUS81-EME1 counterpart. Both cleave 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs. MUS81-EME2 which is active during the replication of DNA is more specifically involved in replication fork processing (PubMed:14609959). Replication forks frequently encounter obstacles to their passage, including DNA base lesions, DNA interstrand cross-links, difficult-to-replicate sequences, transcription bubbles, or tightly bound proteins. One mechanism for the restart of a stalled replication fork involves nucleolytic cleavage mediated by the MUS81-EME2 endonuclease. By acting upon the stalled fork, MUS81-EME2 generates a DNA double-strand break (DSB) that can be repaired by homologous recombination, leading to the restoration of an active fork. MUS81-EME2 could also function in telomere maintenance. MUS81-EME1, on the other hand, is active later in the cell cycle and functions in the resolution of mitotic recombination intermediates including the Holliday junctions, the four-way DNA intermediates that form during homologous recombination (By similarity). {ECO:0000250|UniProtKB:Q96NY9, ECO:0000269|PubMed:14609959, ECO:0000269|PubMed:15205536, ECO:0000269|PubMed:16107704}.
uniprot
proteins
mass_dalton
61531
uniprot
proteins
protein_family
XPF family
uniprot
proteins
pubmed
11741546
uniprot
proteins
pubmed
14609959
uniprot
proteins
pubmed
15205536
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16107704
uniprot
proteins
pubmed
27010503
uniprot
proteins
sequence_length
551
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q96NY9}. Note=Recruited to foci of DNA damage in S-phase cells. {ECO:0000250|UniProtKB:Q96NY9}.
uniprot
proteins