MBD2
entrez
8932
canonical
uniprot
Q9UBB5
canonical
ensembl
ENSG00000134046
resolver
ensp
ENSP00000256429
resolver
ensp
ENSP00000464554
resolver
genesymbol
MBD2
resolver
hgnc
HGNC:6917
resolver
uniprot
O95242
resolver
uniprot
Q9UIS8
resolver
uniprot_entry
MBD2_HUMAN
resolver
uniprot_sec
O95242
resolver
uniprot_sec
Q9UIS8
resolver
amino_acid_sequence
MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA
uniprot
proteins
function
FUNCTION: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669). Binds hemimethylated DNA as well (PubMed:10947852, PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases to chromatin (PubMed:10471499, PubMed:10947852). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Acts as a transcriptional repressor and plays a role in gene silencing (PubMed:10471499, PubMed:10947852, PubMed:16415179). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (PubMed:16415179). May enhance the activation of some unmethylated cAMP-responsive promoters (PubMed:12665568). {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}.
uniprot
proteins
mass_dalton
43255
uniprot
proteins
pubmed
10050851
uniprot
proteins
pubmed
10441743
uniprot
proteins
pubmed
10471499
uniprot
proteins
pubmed
10947852
uniprot
proteins
pubmed
10950960
uniprot
proteins
pubmed
11102443
uniprot
proteins
pubmed
11553631
uniprot
proteins
pubmed
12183469
uniprot
proteins
pubmed
12588985
uniprot
proteins
pubmed
12665568
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15701600
uniprot
proteins
pubmed
16415179
uniprot
proteins
pubmed
16428440
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19729656
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20523938
uniprot
proteins
pubmed
21490301
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24307175
uniprot
proteins
pubmed
27732854
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28977666
uniprot
proteins
pubmed
33283408
uniprot
proteins
pubmed
9774669
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:15701600, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408, ECO:0000269|PubMed:9774669}. Chromosome {ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:27732854}. Note=Nuclear, in discrete foci (PubMed:12183469). Detected at replication foci in late S phase. Localizes to methylated chromatin (PubMed:16428440). Localizes to sites of DNA damage in a manner partially dependent on ZMYND8 (PubMed:27732854). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:27732854}.
uniprot
proteins