Kiss1
entrez
280287
canonical
uniprot
Q6Y4S4
canonical
ensembl
ENSMUSG00000115958
resolver
ensembl
ENSMUSG00000116158
resolver
ensp
ENSMUSP00000142264
resolver
ensp
ENSMUSP00000202303
resolver
ensp
ENSMUSP00000331334
resolver
genesymbol
Kiss1
resolver
uniprot
I0J0X7
resolver
uniprot
Q149Z8
resolver
uniprot
Q68Y93
resolver
uniprot
Q80XF6
resolver
uniprot_entry
I0J0X7_MOUSE
resolver
uniprot_entry
KISS1_MOUSE
resolver
uniprot_sec
Q149Z8
resolver
uniprot_sec
Q68Y93
resolver
uniprot_sec
Q80XF6
resolver
amino_acid_sequence
MISMASWQLLLLLCVATYGEPLAKVAPLVKPGSTGQQSGPQELVNAWEKESRYAESKPGSAGLRARRSSPCPPVEGPAGRQRPLCASRSRLIPAPRGAVLVQREKDLSTYNWNSFGLRYGRRQAARAARG
uniprot
proteins
function
FUNCTION: Kisspeptins are ligands for the G protein-coupled receptor KISS1R/GPR54 (By similarity). The hypothalamic KISS1/KISS1R signaling system plays a central role in the regulation of the hypothalamic-pituitary-gonadal reproductive axis by modulating the secretion of gonadotropin-releasing hormone (GnRH) from GnRH neurons (PubMed:15217982, PubMed:15486019, PubMed:15375028, PubMed:15665093, PubMed:17563351). In these neurons, kisspeptin binding to its receptor activates G(q)-dependent signaling, leading to phospholipase C (PLC) activation, and hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2); the subsequent rise in intracellular calcium levels results in the inhibition of inward rectifier potassium channels and activation of TRPC-like cation channels, leading to GnRH neurons depolarization and stimulation (PubMed:18434521, PubMed:18483150). In addition to this pathway, kisspeptin also triggers G(q)-independent signaling via beta-arrestin, leading to MAPK cascade activation and ERK1/ERK2 phosphorylation (PubMed:25147978). Kisspeptins are also involved in the regulation of other processes including cell growth, cell proliferation and cell migration (By similarity). {ECO:0000250|UniProtKB:Q15726, ECO:0000269|PubMed:15217982, ECO:0000269|PubMed:15375028, ECO:0000269|PubMed:15486019, ECO:0000269|PubMed:15665093, ECO:0000269|PubMed:18434521, ECO:0000269|PubMed:18483150, ECO:0000269|PubMed:25147978}.; FUNCTION: [Kisspeptin-10]: Binds the G protein-coupled receptor KISS1R/GPR54 and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (By similarity). Binding to the receptor also activates beta-arrestin-dependent signaling resulting in ERK1/2 phosphorylation (PubMed:25147978). Activation of the receptor inhibits cell proliferation and cell migration, and is involved in the regulation of trophoblast invasion during early stages of pregnancy. Is also involved in the modulation of airway smooth muscle cells migration (By similarity). In bone tissue, activation of KISS1R by kisspeptin-10 recruits phosphatase DUSP18 and SRC to the KISS1R C-terminus through a G(q)-dependent signaling pathway. This leads to DUSP18-mediated dephosphorylation of SRC, down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (PubMed:38346942). {ECO:0000250|UniProtKB:Q15726, ECO:0000269|PubMed:25147978, ECO:0000269|PubMed:38346942}.; FUNCTION: [Metastin]: Receptor binding triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis by phospholipase C. {ECO:0000250|UniProtKB:Q15726}.
uniprot
proteins
mass_dalton
14117
uniprot
proteins
protein_family
KISS1 family
uniprot
proteins
pubmed
12359743
uniprot
proteins
pubmed
15157736
uniprot
proteins
pubmed
15217982
uniprot
proteins
pubmed
15375028
uniprot
proteins
pubmed
15486019
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15665093
uniprot
proteins
pubmed
17563351
uniprot
proteins
pubmed
18434521
uniprot
proteins
pubmed
18483150
uniprot
proteins
pubmed
25147978
uniprot
proteins
pubmed
38346942
uniprot
proteins
pubmed
39702286
uniprot
proteins
sequence_length
130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q15726}.
uniprot
proteins