Cyp4b1
entrez
24307
canonical
uniprot
P15129
canonical
ensembl
ENSRNOG00000055078
resolver
ensembl
ENSRNOG00055031661
resolver
ensembl
ENSRNOG00060029816
resolver
ensembl
ENSRNOG00065015786
resolver
ensp
ENSRNOP00000013321
resolver
ensp
ENSRNOP00055045297
resolver
ensp
ENSRNOP00060043050
resolver
ensp
ENSRNOP00065020615
resolver
enst
ENSRNOT00055054814
resolver
enst
ENSRNOT00060051785
resolver
enst
ENSRNOT00065026221
resolver
genesymbol
Cyp4b1
resolver
genesymbol_syn
Cyp4b-1
resolver
uniprot_entry
CP4B1_RAT
resolver
amino_acid_sequence
MVLNFLSPSLSRLGLWASVVILMVIVLKLFSLLLRRQKLARAMDSFPGPPTHWLFGHALEIQKLGSLDKVVSWAQQFPHAHPLWFGQFVGFLNIYEPDYAKAVYSRGDPKAADVYDFFLQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACKIAHDHTDEVIRQRKAALQDEKERKKIQQRRHLDFLDILLGVRDESGIKLSDAELRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRGILGDQDSFQWDDLAKMTYLTMCMKECFRLYPPVPQVYRQLNKPVTFVDGRSLPAGSLISLHIYALHRNSTVWPDPEVFDPLRFSPENAAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSLDPSKMPIKVPQLILRSKNGIHLYLKPLASRSGK
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
function
FUNCTION: Catalyzes the omega- and (omega-1)-hydroxylation of saturated fatty acids and n-alkanes (PubMed:2229008). Also bioactivates xenobiotics such as the procarcinogen 3-methoxy-4-aminoazobenzene and the cyclic arylamines 2-aminofluorene and 2-aminoanthracene (By similarity). In addition, catalyzes O-dealkylation of 7-ethoxycoumarin (PubMed:2229008). Functions at the interface of xenobiotic and endobiotic metabolism, contributing both to fatty acid and hydrocarbon oxidation and to the bioactivation of diverse xenobiotics (PubMed:2229008). Preferentially hydroxylates the terminal carbon (omega-hydroxylation) of medium-chain fatty acids (C8-C10), with regioselectivity decreasing as chain length increases. C8 fatty acids and C7 n-alkanes display optimal chain length for regioselective omega-hydroxylation, and n-alkanes (C7-C10) are generally turned over faster and with higher regioselectivity than the corresponding fatty acids. In addition to omega/omega-1 hydroxylation, also catalyzes alpha-, beta-, gamma- and delta-hydroxylation of mid-chain length fatty acids, whereas fatty alcohols of the same chain length are almost exclusively hydroxylated at the omega, omega-1 and omega-2 positions (By similarity). {ECO:0000250|UniProtKB:P15128, ECO:0000250|UniProtKB:Q64462, ECO:0000269|PubMed:2229008}.
uniprot
proteins
mass_dalton
58936
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2229008
uniprot
proteins
pubmed
2725471
uniprot
proteins
sequence_length
511
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P15128}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15128}. Microsome membrane {ECO:0000250|UniProtKB:P15128}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15128}.
uniprot
proteins