Sh3kbp1
entrez
84357
canonical
uniprot
Q925Q9
canonical
ensembl
ENSRNOG00000004322
resolver
ensembl
ENSRNOG00055026871
resolver
ensembl
ENSRNOG00060018228
resolver
ensembl
ENSRNOG00065013202
resolver
ensp
ENSRNOP00000006438
resolver
ensp
ENSRNOP00000006741
resolver
ensp
ENSRNOP00000067100
resolver
ensp
ENSRNOP00000083463
resolver
ensp
ENSRNOP00000089759
resolver
ensp
ENSRNOP00000093532
resolver
ensp
ENSRNOP00000107405
resolver
enst
ENSRNOT00000006438
resolver
enst
ENSRNOT00000006741
resolver
enst
ENSRNOT00000074898
resolver
enst
ENSRNOT00000095370
resolver
enst
ENSRNOT00000113102
resolver
enst
ENSRNOT00000142445
resolver
genesymbol
Sh3kbp1
resolver
genesymbol_syn
Ruk
resolver
genesymbol_syn
Seta
resolver
uniprot
A0A0H2UHD8
resolver
uniprot
A0A8I6A8U3
resolver
uniprot
A0A8I6AJT1
resolver
uniprot
A0ABK0LZJ9
resolver
uniprot
M0RBZ7
resolver
uniprot
Q6IRL5
resolver
uniprot
Q925R0
resolver
uniprot
Q925R1
resolver
uniprot
Q925R2
resolver
uniprot
Q925R3
resolver
uniprot
Q9JKQ0
resolver
uniprot
Q9JKQ1
resolver
uniprot
Q9JLU9
resolver
uniprot_entry
A0A0H2UHD8_RAT
resolver
uniprot_entry
A0A8I6A8U3_RAT
resolver
uniprot_entry
A0A8I6AJT1_RAT
resolver
uniprot_entry
A0ABK0LZJ9_RAT
resolver
uniprot_entry
M0RBZ7_RAT
resolver
uniprot_entry
Q6IRL5_RAT
resolver
uniprot_entry
SH3K1_RAT
resolver
uniprot_sec
Q925R0
resolver
uniprot_sec
Q925R1
resolver
uniprot_sec
Q925R2
resolver
uniprot_sec
Q925R3
resolver
uniprot_sec
Q9JKQ0
resolver
uniprot_sec
Q9JKQ1
resolver
uniprot_sec
Q9JLU9
resolver
amino_acid_sequence
MVEAIVEFDYQAQHDDELTISVGEVITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKDVKKDLLSNKAPEKPMHDVSSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSRPEGFLPASLLPFPAHGAKGKTTFEGTILYRAAPGKTEGHRRYYSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPPATSTPDPSKTEMDSRTKTKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPSDFDKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPETLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLNRPGVLPPRRPERPVGPLTHTRGDSSKIDLAGSTLSGILDKDLSDRSNDIDLEGFDSVISSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGIDVSKKTSRTVTISQVSDNKASLPPKPGTMAAASSGPASLSSVASSPMSSSLGTAGQRASSPSLFSAEGKAKTESAVSSQAAIEELKMQVRELRTIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
uniprot
proteins
function
FUNCTION: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration (By similarity). Has an essential role in the stimulation of B cell activation (By similarity). {ECO:0000250|UniProtKB:Q8R550, ECO:0000250|UniProtKB:Q96B97}.
uniprot
proteins
mass_dalton
78086
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated by CBL and CBLB after EGF stimulation; probably on its C-terminus. {ECO:0000250}.
uniprot
proteins
pubmed
10921882
uniprot
proteins
pubmed
11152963
uniprot
proteins
pubmed
11302255
uniprot
proteins
pubmed
12771190
uniprot
proteins
pubmed
15147912
uniprot
proteins
pubmed
16751601
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
709
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96B97}. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Synapse, synaptosome. Cell junction, focal adhesion. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions. Colocalized with MAGI2 in synaptosomes. Colocalizes with ZFP36 in the cytoplasm (By similarity). Translocation to EGFR containing vesicles upon EGF stimulation is inhibited in the presence of SH3KBP1 (By similarity). {ECO:0000250|UniProtKB:Q8R550, ECO:0000250|UniProtKB:Q96B97}.
uniprot
proteins