Nkx3-1
entrez
18095
canonical
uniprot
P97436
canonical
ensembl
ENSMUSG00000022061
resolver
ensp
ENSMUSP00000022646
resolver
enst
ENSMUST00000022646
resolver
genesymbol
Nkx3-1
resolver
genesymbol_syn
Nkx-3.1
resolver
genesymbol_syn
Nkx3a
resolver
uniprot
O09087
resolver
uniprot
Q3UVH8
resolver
uniprot_entry
NKX31_MOUSE
resolver
uniprot_entry
Q3UVH8_MOUSE
resolver
uniprot_sec
O09087
resolver
amino_acid_sequence
MLRVAEPREPRVEAGGRSPWAAPPTQSKRLTSFLIQDILRDRAERHGGHSGNPQHSPDPRRDSAPEPDKAGGRGVAPEDPPSIRHSPAETPTEPESDAHFETYLLDCEHNPGDLASAPQVTKQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKNLKLTETQVKIWFQNRRYKTKRKQLSEDLGVLEKNSPLSLPALKDDSLPSTSLVSVYTSYPYYPYLYCLGSWHPSFW
uniprot
proteins
function
FUNCTION: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor (By similarity). Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate (PubMed:10215624). Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells (PubMed:12036903). Plays a role in the formation of minor salivary glands (particularly palatine and lingual glands) (PubMed:10906459). {ECO:0000250|UniProtKB:Q99801, ECO:0000269|PubMed:10215624, ECO:0000269|PubMed:10906459, ECO:0000269|PubMed:12036903}.
uniprot
proteins
mass_dalton
26824
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues. {ECO:0000250|UniProtKB:Q99801}.
uniprot
proteins
protein_family
NK-3 homeobox family
uniprot
proteins
pubmed
10215624
uniprot
proteins
pubmed
10415359
uniprot
proteins
pubmed
10906459
uniprot
proteins
pubmed
12036903
uniprot
proteins
pubmed
16814806
uniprot
proteins
pubmed
18816836
uniprot
proteins
pubmed
8943214
uniprot
proteins
pubmed
9142502
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
uniprot
proteins