Adar
entrez
56417
canonical
uniprot
Q99MU3
canonical
ensembl
ENSMUSG00000027951
resolver
ensp
ENSMUSP00000029563
resolver
ensp
ENSMUSP00000096525
resolver
ensp
ENSMUSP00000103028
resolver
ensp
ENSMUSP00000112969
resolver
ensp
ENSMUSP00000113453
resolver
genesymbol
Adar
resolver
uniprot
O70375
resolver
uniprot
Q3UH31
resolver
uniprot
Q80UZ6
resolver
uniprot
Q8C222
resolver
uniprot
Q99MU2
resolver
uniprot
Q99MU4
resolver
uniprot
Q99MU7
resolver
uniprot_entry
DSRAD_MOUSE
resolver
uniprot_entry
Q3UH31_MOUSE
resolver
uniprot_sec
O70375
resolver
uniprot_sec
Q80UZ6
resolver
uniprot_sec
Q8C222
resolver
uniprot_sec
Q99MU2
resolver
uniprot_sec
Q99MU4
resolver
uniprot_sec
Q99MU7
resolver
amino_acid_sequence
MSQGFRGPTGVFPHQTQSYLDPSHEHSKWRYPQPQGPESYPRSFQLQQIEFLKGRLPEAPLIGIQTQSLPPFLPGHWPRFPGPPAQDRQLEIWEFPRSVTLRNQGFHIGPPLPPPHSRGTPWRGADGLCSHFRELSISQSPEQKVLNRLEELGEGKATTAHVLARELRIPKRDINRILYSLEKKGKLHRGRGKPPLWSLVPLSQAWTQPPGVVNPDSCIQEFPRGEPGLDSEDGDPASDLEGPSEPLDMAEIKEKICDYLFNVSNSSALNLAKNIGLTKARDVTSVLIDLERQGDVYRQGATPPIWYLTDKKRERLQMKRSTHSAPAPTPTAVPEATRSPSFPACHPPPAGASSSVAASKRVENGQEPAIKHESRHEARPGPMRLRPHAYHNGPSRAGYVASENGQWATDDIPDNLNSIHTAPGEFRAIMEMPSFYSPTLPRCSPYKKLTECQLKNPVSGLLEYAQFTSQTCDFNLIEQSGPSHEPRFKFQVVINGREFPPAEAGSKKVAKQDAAVKAMAILLREAKAKDSGQPEDLSHCPMEEDSEKPAEAQAPSSSATSLFSGKSPVTTLLECMHKLGNSCEFRLLSKEGPAHDPKFQYCVAVGAQTFPPVSAPSKKVAKQMAAEEAMKALQEEAASSADDQSGGANTDSLDESMAPNKIRRIGELVRYLNTNPVGGLLEYARSHGFAAEFKLIDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQGKQDAADAALRVLIGESEKAEQLGFAEVTPVTGASLRRTMLLLSRSPDAHPKTLPLSGSTFHDQIAMLSHRCFNALTNSFQPSLLGRKILAAIIMKRDPEDMGVVVSLGTGNRCVKGDSLSLKGETVNDCHAEIISRRGFIRFLYSELMKYNHHTAKNSIFELARGGEKLQIKKTVSFHLYISTAPCGDGALFDKSCSDRAVESTESRHYPVFENPKQGKLRTKVENGEGTIPVESSDIVPTWDGIRLGERLRTMSCSDKILRWNVLGLQGALLTHFLQPVYLKSVTLGYLFSQGHLTRAICCRVTRDGKAFEDGLRYPFIVNHPKVGRVSVYDSKRQSGKTKETSVNWCMADGYDLEILDGTRGTVDGPGKELSRVSKKNIFLQFKKLCSFRARRDLLQLSYGEAKKAARDYDLAKNYFKKSLRDMGYGNWISKPQEEKNFYLCPVPND
uniprot
proteins
ec_number
3.5.4.37
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Does not affect polyomavirus replication but provides protection against virus-induced cytopathic effects. Essential for embryonic development and cell survival and plays a critical role in the maintenance of hematopoietic stem cells. {ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:17369310}.
uniprot
proteins
mass_dalton
130447
uniprot
proteins
post_translational_modification
PTM: Sumoylation reduces RNA-editing activity. {ECO:0000250|UniProtKB:P55265}.
uniprot
proteins
pubmed
12618436
uniprot
proteins
pubmed
12709013
uniprot
proteins
pubmed
12954622
uniprot
proteins
pubmed
14613934
uniprot
proteins
pubmed
14615479
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15556947
uniprot
proteins
pubmed
16055709
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17079286
uniprot
proteins
pubmed
17369310
uniprot
proteins
pubmed
21182352
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
1178
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus, nucleolus. Note=Long forms starting at Met-1 are found predominantly in cytoplasm. Shuttles between the cytoplasm and nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus, nucleolus. Note=Long forms starting at Met-1 are found predominantly in cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleolus. Note=Short forms starting at Met-519 are found exclusively in the nucleolus.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus, nucleolus. Note=Short forms starting at Met-519 are found exclusively in the nucleolus.
uniprot
proteins