ATF7IP
entrez
55729
canonical
uniprot
Q6VMQ6
canonical
ensembl
ENSG00000171681
resolver
ensp
ENSP00000261168
resolver
ensp
ENSP00000440440
resolver
ensp
ENSP00000443179
resolver
ensp
ENSP00000444589
resolver
ensp
ENSP00000445955
resolver
ensp
ENSP00000639362
resolver
ensp
ENSP00000639363
resolver
genesymbol
ATF7IP
resolver
genesymbol_syn
MCAF
resolver
genesymbol_syn
MCAF1
resolver
hgnc
HGNC:20092
resolver
uniprot
B3KNI7
resolver
uniprot
B3KQF8
resolver
uniprot
F5GX74
resolver
uniprot
G3V1U0
resolver
uniprot
Q4G0T9
resolver
uniprot
Q6P3T3
resolver
uniprot
Q86XW5
resolver
uniprot
Q9NVJ9
resolver
uniprot
Q9NWC2
resolver
uniprot
Q9Y4X8
resolver
uniprot_entry
B3KNI7_HUMAN
resolver
uniprot_entry
B3KQF8_HUMAN
resolver
uniprot_entry
MCAF1_HUMAN
resolver
uniprot_sec
F5GX74
resolver
uniprot_sec
G3V1U0
resolver
uniprot_sec
Q4G0T9
resolver
uniprot_sec
Q6P3T3
resolver
uniprot_sec
Q86XW5
resolver
uniprot_sec
Q9NVJ9
resolver
uniprot_sec
Q9NWC2
resolver
uniprot_sec
Q9Y4X8
resolver
amino_acid_sequence
MDSLEEPQKKVFKARKTMRVSDRQQLEAVYKVKEELLKTDVKLLNGNHENGDLDPTSPLENMDYIKDKEEVNGIEEICFDPEGSKAEWKETPCILSVNVKNKQDDDLNCEPLSPHNITPEPVSKLPAEPVSGDPAPGDLDAGDPASGVLASGDSTSGDPTSSEPSSSDAASGDATSGDAPSGDVSPGDATSGDATADDLSSGDPTSSDPIPGEPVPVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGDLSSSELASDDLATGELASDELTSESTFDRTFEPKSVPVCEPVPEIDNIEPSSNKDDDFLEKNGADEKLEQIQSKDSLDEKNKADNNIDANEETLETDDTTICSDRPPENEKKVEEDIITELALGEDAISSSMEIDQGEKNEDETSADLVETINENVIEDNKSENILENTDSMETDEIIPILEKLAPSEDELTCFSKTSLLPIDETNPDLEEKMESSFGSPSKQESSESLPKEAFLVLSDEEDISGEKDESEVISQNETCSPAEVESNEKDNKPEEEEQVIHEDDERPSEKNEFSRRKRSKSEDMDNVQSKRRRYMEEEYEAEFQVKITAKGDINQKLQKVIQWLLEEKLCALQCAVFDKTLAELKTRVEKIECNKRHKTVLTELQAKIARLTKRFEAAKEDLKKRHEHPPNPPVSPGKTVNDVNSNNNMSYRNAGTVRQMLESKRNVSESAPPSFQTPVNTVSSTNLVTPPAVVSSQPKLQTPVTSGSLTATSVLPAPNTATVVATTQVPSGNPQPTISLQPLPVILHVPVAVSSQPQLLQSHPGTLVTNQPSGNVEFISVQSPPTVSGLTKNPVSLPSLPNPTKPNNVPSVPSPSIQRNPTASAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSPSTNRGPIQMKIPISAFSTSSAAEQNSNTTPRIENQTNKTIDASVSKKAADSTSQCGKATGSDSSGVIDLTMDDEESGASQDPKKLNHTPVSTMSSSQPVSRPLQPIQPAPPLQPSGVPTSGPSQTTIHLLPTAPTTVNVTHRPVTQVTTRLPVPRAPANHQVVYTTLPAPPAQAPLRGTVMQAPAVRQVNPQNSVTVRVPQTTTYVVNNGLTLGSTGPQLTVHHRPPQVHTEPPRPVHPAPLPEAPQPQRLPPEAASTSLPQKPHLKLARVQSQNGIVLSWSVLEVDRSCATVDSYHLYAYHEEPSATVPSQWKKIGEVKALPLPMACTLTQFVSGSKYYFAVRAKDIYGRFGPFCDPQSTDVISSTQSS
uniprot
proteins
function
FUNCTION: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}.
uniprot
proteins
mass_dalton
136394
uniprot
proteins
mutagenesis
MUTAGEN 968; /note="D->A: Abolishes the interaction with SUMO."; /evidence="ECO:0000269|PubMed:16757475"; MUTAGEN 969; /note="L->A: Abolishes the interaction with SUMO."; /evidence="ECO:0000269|PubMed:16757475"; MUTAGEN 1224; /note="L->R: Abolishes interaction with MBD1 and subsequent transcriptional repression."; /evidence="ECO:0000269|PubMed:15691849
uniprot
proteins
protein_family
MCAF family
uniprot
proteins
pubmed
10976766
uniprot
proteins
pubmed
12659632
uniprot
proteins
pubmed
12665582
uniprot
proteins
pubmed
14536086
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15691849
uniprot
proteins
pubmed
16314315
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16757475
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18842587
uniprot
proteins
pubmed
19106100
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27732843
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
1270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}.
uniprot
proteins