NCEH1
entrez
57552
canonical
uniprot
Q6PIU2
canonical
ensembl
ENSG00000144959
resolver
ensp
ENSP00000418571
resolver
ensp
ENSP00000442464
resolver
ensp
ENSP00000443227
resolver
enst
ENST00000538775
resolver
genesymbol
NCEH1
resolver
genesymbol_syn
AADACL1
resolver
genesymbol_syn
KIAA1363
resolver
hgnc
HGNC:29260
resolver
uniprot
A0A0A0MTJ9
resolver
uniprot
B7Z2K4
resolver
uniprot
B7Z3A1
resolver
uniprot
B7Z5U2
resolver
uniprot
B7Z906
resolver
uniprot
B7ZAW6
resolver
uniprot
F5H7K4
resolver
uniprot
Q86WZ1
resolver
uniprot
Q9P2I4
resolver
uniprot_entry
A0A0A0MTJ9_HUMAN
resolver
uniprot_entry
NCEH1_HUMAN
resolver
uniprot_sec
B7Z2K4
resolver
uniprot_sec
B7Z3A1
resolver
uniprot_sec
B7Z5U2
resolver
uniprot_sec
B7Z906
resolver
uniprot_sec
B7ZAW6
resolver
uniprot_sec
F5H7K4
resolver
uniprot_sec
Q86WZ1
resolver
uniprot_sec
Q9P2I4
resolver
amino_acid_sequence
MRSSCVLLTALVALAAYYVYIPLPGSVSDPWKLMLLDATFRGAQQVSNLIHYLGLSHHLLALNFIIVSFGKKSAWSSAQVKVTDTDFDGVEVRVFEGPPKPEEPLKRSVVYIHGGGWALASAKIRYYDELCTAMAEELNAVIVSIEYRLVPKVYFPEQIHDVVRATKYFLKPEVLQKYMVDPGRICISGDSAGGNLAAALGQQFTQDASLKNKLKLQALIYPVLQALDFNTPSYQQNVNTPILPRYVMVKYWVDYFKGNYDFVQAMIVNNHTSLDVEEAAAVRARLNWTSLLPASFTKNYKPVVQTTGNARIVQELPQLLDARSAPLIADQAVLQLLPKTYILTCEHDVLRDDGIMYAKRLESAGVEVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL
uniprot
proteins
ec_number
3.1.1.-
uniprot
proteins
ec_number
3.1.1.71
uniprot
proteins
function
FUNCTION: Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed:17052608). May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity). May contribute to cancer pathogenesis by promoting tumor cell migration (PubMed:17052608). {ECO:0000250|UniProtKB:Q8BLF1, ECO:0000269|PubMed:17052608}.
uniprot
proteins
mass_dalton
45808
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:12149457, ECO:0000269|PubMed:19159218}.
uniprot
proteins
protein_family
'GDXG' lipolytic enzyme family
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
12149457
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17052608
uniprot
proteins
pubmed
18782767
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
408
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17052608, ECO:0000305|PubMed:12149457}; Single-pass type II membrane protein {ECO:0000305|PubMed:12149457}. Microsome {ECO:0000250|UniProtKB:Q8BLF1}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins