EGR1
entrez
1958
canonical
uniprot
P18146
canonical
ensembl
ENSG00000120738
resolver
ensp
ENSP00000239938
resolver
enst
ENST00000239938
resolver
genesymbol
EGR1
resolver
genesymbol_syn
KROX24
resolver
genesymbol_syn
ZNF225
resolver
hgnc
HGNC:3238
resolver
uniprot
Q546S1
resolver
uniprot_entry
EGR1_HUMAN
resolver
uniprot_entry
Q546S1_HUMAN
resolver
amino_acid_sequence
MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGAPEGSGSNSSSSSSGGGGGGGGGSNSSSSSSTFNPQADTGEQPYEHLTAESFPDISLNNEKVLVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPASSSSAPSPAASSASASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPAAKGGFQVPMIPDYLFPQQQGDLGLGTPDQKPFQGLESRTQQPSLTPLSTIKAFATQSGSQDLKALNTSYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASSATSSLSSYPSPVATSYPSPVTTSYPSPATTSYPSPVPTSFSSPGSSTYPSPVHSGFPSPSVATTYSSVPPAFPAQVSSFPSSAVTNSFSASTGLSDMTATFSPRTIEIC
uniprot
proteins
function
FUNCTION: Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). {ECO:0000250|UniProtKB:P08046, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311}.
uniprot
proteins
mass_dalton
57507
uniprot
proteins
protein_family
EGR C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1569051
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20121949
uniprot
proteins
pubmed
20363028
uniprot
proteins
pubmed
2110381
uniprot
proteins
pubmed
2377485
uniprot
proteins
pubmed
25258363
uniprot
proteins
pubmed
25999311
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
543
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20363028}. Cytoplasm {ECO:0000269|PubMed:20363028}.
uniprot
proteins