Rnf135
entrez
71956
canonical
uniprot
Q9CWS1
canonical
ensembl
ENSMUSG00000020707
resolver
ensp
ENSMUSP00000017839
resolver
ensp
ENSMUSP00000271364
resolver
genesymbol
Rnf135
resolver
uniprot
B2RRA5
resolver
uniprot
Q3UBK5
resolver
uniprot
Q8R161
resolver
uniprot
Q9DCH3
resolver
uniprot_entry
B2RRA5_MOUSE
resolver
uniprot_entry
RN135_MOUSE
resolver
uniprot_sec
Q3UBK5
resolver
uniprot_sec
Q8R161
resolver
uniprot_sec
Q9DCH3
resolver
amino_acid_sequence
MAAVCSGNAVPVWLSEDDLSCIICQGLLDQPTTLPCGHSFCLRCLHDLWVSKRGAVDGCPWACPICRKGPLTKPKLHKNPLLQDLVDKYLQAAREVEAGSEPEPAPAPRSAPQVTVQKSTTNVIQELTDMVRQLVDDVKSLQTQRPNLGSGQDNAQGTPPTDSSSEGEHSLDSPKLVTFSISQKKIQEILHNLEEIQEKLQGSVPGRAPPRERVQEMTSSLCLLPDQRRPAPRKASHLSLWAISPTFDLRTLSYNLEVSNNSRRVTVSRGDLHTYHWSPQRFSISQVFCSQALSSGQKYWEVDTRNCSHWAIGVASWGMKRDGMLGRTMDSWCIEWRGPGQFSAWAKMKKTDLQSDLPEVVGVWLDLESGELAFYAVADHERLLYECEVSSSSPLHPAFWLYGLSPGNYLEIKQLNT
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531). Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway (PubMed:21147464, PubMed:28469175, PubMed:31006531). Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway (PubMed:31006531). This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (PubMed:31006531). Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway (By similarity). It is not involved in the innate immune response against DNA viruses (PubMed:21147464). {ECO:0000250|UniProtKB:Q8IUD6, ECO:0000269|PubMed:21147464, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:31006531}.
uniprot
proteins
mass_dalton
46462
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:21147464}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21147464
uniprot
proteins
pubmed
23950712
uniprot
proteins
pubmed
28469175
uniprot
proteins
pubmed
31006531
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28469175}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q8IUD6}.
uniprot
proteins