Blk
entrez
12143
canonical
uniprot
P16277
canonical
ensembl
ENSMUSG00000014453
resolver
ensp
ENSMUSP00000014597
resolver
enst
ENSMUST00000014597
resolver
genesymbol
Blk
resolver
uniprot
Q8K2M8
resolver
uniprot_entry
BLK_MOUSE
resolver
uniprot_sec
Q8K2M8
resolver
activity_regulation
ACTIVITY REGULATION: Antibody-mediated surface engagement of the B-cell antigen receptor (BCR) which results in the phosphorylation of BLK on tyrosine residues, stimulates the enzymatic activity. {ECO:0000269|PubMed:1714601, ECO:0000269|PubMed:7524079}.
uniprot
proteins
amino_acid_sequence
MGLLSSKRQVSEKGKGWSPVKIRTQDKAPPPLPPLVVFNHLAPPSPNQDPDEEERFVVALFDYAAVNDRDLQVLKGEKLQVLRSTGDWWLARSLVTGREGYVPSNFVAPVETLEVEKWFFRTISRKDAERQLLAPMNKAGSFLIRESESNKGAFSLSVKDITTQGEVVKHYKIRSLDNGGYYISPRITFPTLQALVQHYSKKGDGLCQKLTLPCVNLAPKNLWAQDEWEIPRQSLKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVTREPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEHGYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQSVLEDFYTATEGQYELQP
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (PubMed:12563261, PubMed:14662906, PubMed:2404338, PubMed:7608542, PubMed:7690139, PubMed:9636152). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:12563261, PubMed:14662906, PubMed:2404338, PubMed:7608542, PubMed:7690139). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (PubMed:12563261, PubMed:14662906, PubMed:2404338, PubMed:7608542, PubMed:7690139). Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (PubMed:7592958, PubMed:9177269). Also phosphorylates the immunoglobulin G receptor FCGR2 (By similarity). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (PubMed:12563261, PubMed:14662906). Also contributes to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (PubMed:7565679). In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (By similarity). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (By similarity). {ECO:0000250|UniProtKB:P51451, ECO:0000269|PubMed:12563261, ECO:0000269|PubMed:14662906, ECO:0000269|PubMed:2404338, ECO:0000269|PubMed:7565679, ECO:0000269|PubMed:7592958, ECO:0000269|PubMed:7608542, ECO:0000269|PubMed:7690139, ECO:0000269|PubMed:9177269, ECO:0000269|PubMed:9636152}.
uniprot
proteins
mass_dalton
56674
uniprot
proteins
mutagenesis
MUTAGEN 145; /note="R->K: Impairs the interaction with CD79A and CD79B."; /evidence="ECO:0000269|PubMed:7592958"; MUTAGEN 495; /note="Y->F: Leads to constitutive activation of BLK."; /evidence="ECO:0000269|PubMed:14662906, ECO:0000269|PubMed:9636152
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues after antibody-mediated surface engagement of the B-cell antigen receptor (BCR).; PTM: Ubiquitination of activated BLK by the UBE3A ubiquitin protein ligase leads to its degradation by the ubiquitin-proteasome pathway. {ECO:0000269|PubMed:10449731}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SRC subfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10449731
uniprot
proteins
pubmed
12563261
uniprot
proteins
pubmed
14662906
uniprot
proteins
pubmed
1506682
uniprot
proteins
pubmed
1537861
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1714601
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23562159
uniprot
proteins
pubmed
2404338
uniprot
proteins
pubmed
7524079
uniprot
proteins
pubmed
7565679
uniprot
proteins
pubmed
7592958
uniprot
proteins
pubmed
7608542
uniprot
proteins
pubmed
7690139
uniprot
proteins
pubmed
8195169
uniprot
proteins
pubmed
8639560
uniprot
proteins
pubmed
9177269
uniprot
proteins
pubmed
9636152
uniprot
proteins
pubmed
9660839
uniprot
proteins
sequence_length
499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Present and active in lipid rafts (By similarity). Membrane location is required for the phosphorylation of CD79A and CD79B. {ECO:0000250, ECO:0000269|PubMed:7592958}.
uniprot
proteins