Tmbim6
entrez
24822
canonical
uniprot
P55062
canonical
ensembl
ENSRNOG00000055579
resolver
ensp
ENSRNOP00000073494
resolver
ensp
ENSRNOP00000094489
resolver
ensp
ENSRNOP00000109048
resolver
enst
ENSRNOT00000105911
resolver
enst
ENSRNOT00000169101
resolver
genesymbol
Tmbim6
resolver
genesymbol_syn
Bi1
resolver
genesymbol_syn
Tegt
resolver
uniprot
A0ABK0M207
resolver
uniprot
Q64712
resolver
uniprot
Q6PDV4
resolver
uniprot_entry
A0ABK0M207_RAT
resolver
uniprot_entry
BI1_RAT
resolver
uniprot_sec
Q64712
resolver
uniprot_sec
Q6PDV4
resolver
amino_acid_sequence
MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHVVTRFIQAGLLSALGALALMICLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALELCIAINPSILPTAFMGTAMIFTCFSLSALYARRRSYLFLGGILMSAMSLMFVSSLGNLFFGSIWLFQANLYMGLLVMCGFVLFDTQLIIEKAEHGDKDYIWHCIDLFLDFVTLFRKLMLILAFNEKDKKKEKK
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER)-resident protein that confers cellular protection as an anti-apoptotic protein by limiting multiple stress-inducing pathways surrounding the endoplasmic reticulum and mitochondria. Inhibits the activities of the key sensor for the endoplasmic reticulum unfolded protein response IRE1alpha/ERN1 both directly and by blocking BAX/BAK binding. Modulates ER calcium homeostasis by acting as a calcium-leak channel (By similarity). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity). {ECO:0000250|UniProtKB:P55061, ECO:0000250|UniProtKB:Q9D2C7}.
uniprot
proteins
mass_dalton
26464
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by BFAR, leading to proteasomal degradation. {ECO:0000250|UniProtKB:P55061}.
uniprot
proteins
protein_family
BI1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8012111
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P55061}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55061}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins