Foxp2
entrez
114142
canonical
uniprot
P58463
canonical
ensembl
ENSMUSG00000029563
resolver
ensp
ENSMUSP00000031545
resolver
ensp
ENSMUSP00000111132
resolver
ensp
ENSMUSP00000111137
resolver
genesymbol
Foxp2
resolver
uniprot
Q6PD37
resolver
uniprot
Q8C4F0
resolver
uniprot
Q8R441
resolver
uniprot_entry
FOXP2_MOUSE
resolver
uniprot_sec
Q6PD37
resolver
uniprot_sec
Q8C4F0
resolver
uniprot_sec
Q8R441
resolver
amino_acid_sequence
MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSEKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSTTSKASPPITHHSIVNGQSSVLNARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE
uniprot
proteins
function
FUNCTION: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. {ECO:0000269|PubMed:14701752, ECO:0000269|PubMed:24179158}.
uniprot
proteins
mass_dalton
79819
uniprot
proteins
mutagenesis
MUTAGEN 399; /note="Missing: Loss of dimerization. Almost complete loss of DNA-binding. Reduced transcriptional repression activity."; /evidence="ECO:0000269|PubMed:14701752"; MUTAGEN 407..408; /note="HL->AA: Severely reduced transcriptional repression activity."; /evidence="ECO:0000269|PubMed:14701752"; MUTAGEN 408; /note="L->A: Severely reduced transcriptional repression activity."; /evidence="ECO:0000269|PubMed:14701752"; MUTAGEN 421..425; /note="PLNLV->AANAA: No significant effect on transcriptional repression activity."; /evidence="ECO:0000269|PubMed:14701752"; MUTAGEN 552; /note="R->H: No change in synaptic density."; /evidence="ECO:0000269|PubMed:24179158
uniprot
proteins
pubmed
11358962
uniprot
proteins
pubmed
12192408
uniprot
proteins
pubmed
14516685
uniprot
proteins
pubmed
14701752
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24179158
uniprot
proteins
sequence_length
714
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins