EFR3B
entrez
22979
canonical
uniprot
Q9Y2G0
canonical
ensembl
ENSG00000084710
resolver
ensp
ENSP00000384081
resolver
ensp
ENSP00000385832
resolver
enst
ENST00000402191
resolver
genesymbol
EFR3B
resolver
genesymbol_syn
KIAA0953
resolver
hgnc
HGNC:29155
resolver
uniprot
B3KT90
resolver
uniprot
B7WPL8
resolver
uniprot
E7ESK9
resolver
uniprot
Q86XU6
resolver
uniprot_entry
B3KT90_HUMAN
resolver
uniprot_entry
E7ESK9_HUMAN
resolver
uniprot_entry
EFR3B_HUMAN
resolver
uniprot_sec
B7WPL8
resolver
uniprot_sec
Q86XU6
resolver
amino_acid_sequence
MYGVCGCCGALRPRYKRLVDNIFPEDPEDGLVKTNMEKLTFYALSAPEKLDRIGAYLSERLIRDVGRHRYGYVCIAMEALDQLLMACHCQSINLFVESFLKMVAKLLESEKPNLQILGTNSFVKFANIEEDTPSYHRSYDFFVSRFSEMCHSSHDDLEIKTKIRMSGIKGLQGVVRKTVNDELQANIWDPQHMDKIVPSLLFNLQHVEEAESRSPSPLQAPEKEKESPAELAERCLRELLGRAAFGNIKNAIKPVLIHLDNHSLWEPKVFAIRCFKIIMYSIQPQHSHLVIQQLLGHLDANSRSAATVRAGIVEVLSEAAVIAATGSVGPTVLEMFNTLLRQLRLSIDYALTGSYDGAVSLGTKIIKEHEERMFQEAVIKTVGSFASTLPTYQRSEVILFIMSKVPRPSLHQAVDTGRTGENRNRLTQIMLLKSLLQVSTGFQCNNMMSALPSNFLDRLLSTALMEDAEIRLFVLEILISFIDRHGNRHKFSTISTLSDISVLKLKVDKCSRQDTVFMKKHSQQLYRHIYLSCKEETNVQKHYEALYGLLALISIELANEEVVVDLIRLVLAVQDVAQVNEENLPVYNRCALYALGAAYLNLISQLTTVPAFCQHIHEVIETRKKEAPYMLPEDVFVERPRLSQNLDGVVIELLFRQSKISEVLGGSGYNSDRLCLPYIPQLTDEDRLSKRRSIGETISLQVEVESRNSPEKEERVPAEEITYETLKKAIVDSVAVEEQERERRRQVVEKFQKAPFEEIAAHCGARASLLQSKLNQIFEITIRPPPSPSGTITAAYGQPQNHSIPVYEMKFPDLCVY
uniprot
proteins
function
FUNCTION: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3B probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000269|PubMed:26571211, ECO:0000305}.
uniprot
proteins
mass_dalton
92487
uniprot
proteins
mutagenesis
MUTAGEN 5..8; /note="CGCC->SGSS: Induces localization to the cytosol."; /evidence="ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825
uniprot
proteins
post_translational_modification
PTM: Palmitoylated at its N-terminus, anchoring the protein to the plasma membrane. {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825}.
uniprot
proteins
protein_family
EFR3 family
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23229899
uniprot
proteins
pubmed
25380825
uniprot
proteins
pubmed
25608530
uniprot
proteins
pubmed
26571211
uniprot
proteins
sequence_length
817
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825}; Lipid-anchor {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825}. Cytoplasm, cytosol {ECO:0000269|PubMed:25380825}. Note=Palmitoylation anchors the protein to the plasma membrane (PubMed:23229899, PubMed:25380825). A small amount is observed in the cytosol (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825}.
uniprot
proteins