Ifi35
entrez
70110
canonical
uniprot
Q9D8C4
canonical
ensembl
ENSMUSG00000010358
resolver
ensp
ENSMUSP00000010502
resolver
enst
ENSMUST00000010502
resolver
genesymbol
Ifi35
resolver
genesymbol_syn
Ifp35
resolver
uniprot
Q3V2E7
resolver
uniprot_entry
IN35_MOUSE
resolver
uniprot_sec
Q3V2E7
resolver
amino_acid_sequence
MSVTLQTVLYSLQEEQARLKMRLQELQQLKRERTGSPGAKIPFSVPEVPLVFQGQTKQGRQVPKFVVSNLKVCCPLPEGSALVTFEDPKVVDRLLQQKEHRVNLEDCRLRVQVQPLELPVVTNIQVSSQPDNHRVLVSGFPAGLRLSEEELLDKLEIFFGKAKNGGGDVETREMLQGTVMLGFADEEVAQHLCQIGQFRVPLDRQQVLLRVSPYVSGEIQKAEIKFQQAPHSVLVTNIPDVMDAQELHDILEIHFQKPTRGGGEVEALTVVPSGQQGLAIFTSESS
uniprot
proteins
function
FUNCTION: Acts as a signaling pathway regulator involved in innate immune system response (PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with transcriptional regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (By similarity). In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (By similarity). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (By similarity). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (By similarity). {ECO:0000250|UniProtKB:P80217, ECO:0000269|PubMed:29350881}.
uniprot
proteins
mass_dalton
31876
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Dephosphorylation correlates with the formation of a complex with NMI. {ECO:0000250|UniProtKB:P80217}.
uniprot
proteins
protein_family
NMI family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29038465
uniprot
proteins
pubmed
29350881
uniprot
proteins
sequence_length
286
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P80217}. Nucleus {ECO:0000250|UniProtKB:P80217}. Secreted {ECO:0000250|UniProtKB:P80217}. Note=Cytoplasmic IFI35 localizes in punctate granular structures (By similarity). Nuclear localization increased following IFN-alpha treatment (By similarity). Extracellular following secretion by macrophage (By similarity). {ECO:0000250|UniProtKB:P80217}.
uniprot
proteins