GRIN2C
entrez
2905
canonical
uniprot
Q14957
canonical
ensembl
ENSG00000161509
resolver
ensp
ENSP00000293190
resolver
ensp
ENSP00000338645
resolver
ensp
ENSP00000561125
resolver
ensp
ENSP00000610976
resolver
ensp
ENSP00000610977
resolver
ensp
ENSP00000610978
resolver
ensp
ENSP00000610979
resolver
ensp
ENSP00000720894
resolver
enst
ENST00000293190
resolver
enst
ENST00000347612
resolver
enst
ENST00000891066
resolver
enst
ENST00000940920
resolver
genesymbol
GRIN2C
resolver
genesymbol
NMDAR2C
resolver
genesymbol_syn
NMDAR2C
resolver
hgnc
HGNC:4587
resolver
uniprot
A0A8D9PH81
resolver
uniprot
B2RTT1
resolver
uniprot
H0Y2V8
resolver
uniprot
O15398
resolver
uniprot
Q8IW23
resolver
uniprot_entry
A0A8D9PH81_HUMAN
resolver
uniprot_entry
H0Y2V8_HUMAN
resolver
uniprot_entry
NMDE3_HUMAN
resolver
uniprot_entry
O15398_HUMAN
resolver
uniprot_entry
Q8IW23_HUMAN
resolver
uniprot_sec
B2RTT1
resolver
amino_acid_sequence
MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPLEIQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAARDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGWGPPDGGRAALVRRAPQPPGRPPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASERPLSPARCHYSSFPRADRSGRPFLPLFPELEDLPLLGPEQLARREALLHAAWARGSRPRHASLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRLAQAQSMCLPIYREACQEGEQAGAPAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGHRGRTLGLGTGYRDSGGLDEISRVARGTQGFPGPCTWRRISSLESEV
uniprot
proteins
function
FUNCTION: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26875626, PubMed:36309015). Participates in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current and long-term synaptic potentiation (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626, PubMed:36309015). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626). {ECO:0000250|UniProtKB:P35438, ECO:0000250|UniProtKB:Q01098, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:36309015}.
uniprot
proteins
mass_dalton
134209
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
protein_family
NR2C/GRIN2C subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
21300787
uniprot
proteins
pubmed
22833210
uniprot
proteins
pubmed
26875626
uniprot
proteins
pubmed
36309015
uniprot
proteins
pubmed
9037519
uniprot
proteins
sequence_length
1233
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26875626}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 555..575; /note="Helical"; /evidence="ECO:0000269|PubMed:36309015, ECO:0007744|PDB:8E93, ECO:0007744|PDB:8E97"; TRANSMEM 627..644; /note="Helical"; /evidence="ECO:0000269|PubMed:36309015, ECO:0007744|PDB:8E93, ECO:0007744|PDB:8E97"; TRANSMEM 814..836; /note="Helical"; /evidence="ECO:0000269|PubMed:36309015, ECO:0007744|PDB:8E93, ECO:0007744|PDB:8E97
uniprot
proteins