Spn
entrez
20737
canonical
uniprot
P15702
canonical
ensembl
ENSMUSG00000051457
resolver
ensp
ENSMUSP00000049534
resolver
ensp
ENSMUSP00000122787
resolver
enst
ENSMUST00000049931
resolver
enst
ENSMUST00000143713
resolver
genesymbol
Spn
resolver
uniprot
Q544C5
resolver
uniprot_entry
LEUK_MOUSE
resolver
uniprot_entry
Q544C5_MOUSE
resolver
amino_acid_sequence
MALHLLLLFGACWVQVASPDSLQRTTMLPSTPHITAPSTSEAQNASPSVSVGSGTVDSKETISPWGQTTIPVSLTPLETTELSSLETSAGASMSTPVPEPTASQEVSSKTSALLPEPSNVASDPPVTAANPVTDGPAANPVTDGTAASTSISKGTSAPPTTVTTSSNETSGPSVATTVSSKTSGPPVTTATGSLGPSSEMHGLPATTATSSVESSSVARGTSVSSRKTSTTSTQDPITTRSPSQESSGMLLVPMLIALVVVLALVALLLLWRQRQKRRTGALTLSGGGKRNGVVDAWAGPARVPDEEATTTSGAGGNKGSEVLETEGSGQRPTLTTFFSRRKSRQGSLVLEELKPGSGPNLKGEEEPLVGSEDEAVETPTSDGPQAKDEAAPQSL
uniprot
proteins
function
FUNCTION: Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (PubMed:11728336, PubMed:17638845, PubMed:21289089). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment (PubMed:18490738). Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (By similarity). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin (PubMed:26700769). Acts as a T-cell counter-receptor for SIGLEC1 (PubMed:11238599). {ECO:0000250|UniProtKB:P16150, ECO:0000269|PubMed:11238599, ECO:0000269|PubMed:11728336, ECO:0000269|PubMed:17638845, ECO:0000269|PubMed:18490738, ECO:0000269|PubMed:21289089, ECO:0000269|PubMed:26700769}.; FUNCTION: [CD43 cytoplasmic tail]: Protects cells from apoptotic signals, promoting cell survival. {ECO:0000269|PubMed:19696198}.
uniprot
proteins
mass_dalton
40038
uniprot
proteins
mutagenesis
MUTAGEN 276..278; /note="KRR->NGG: Loss of phosphorylation, interaction with EZR and localization to the uropodium."; /evidence="ECO:0000269|PubMed:21289089"; MUTAGEN 278; /note="R->A: Significant reduction in interaction with RDX."; /evidence="ECO:0000269|PubMed:18614175"; MUTAGEN 279; /note="T->A: No effect on its interaction with RDX."; /evidence="ECO:0000269|PubMed:18614175"; MUTAGEN 282; /note="L->A: Significant reduction in interaction with RDX."; /evidence="ECO:0000269|PubMed:18614175"; MUTAGEN 284; /note="L->A: Significant reduction in interaction with RDX."; /evidence="ECO:0000269|PubMed:18614175"; MUTAGEN 343; /note="S->A: Reduced phosphorylation. Significant loss of phosphorylation; when associated with A-347."; /evidence="ECO:0000269|PubMed:17638845"; MUTAGEN 347; /note="S->A: Reduced phosphorylation. Significant loss of phosphorylation; when associated with A-343."; /evidence="ECO:0000269|PubMed:17638845, ECO:0000269|PubMed:21289089"; MUTAGEN 347; /note="S->D: No loss of phosphorylation or localization to the uropodium. Loss of interaction with EZR."; /evidence="ECO:0000269|PubMed:21289089
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-347 is regulated by chemokines, requires its association with ERM proteins (EZR, RDX and MSN) and is essential for its function in the regulation of T-cell trafficking to lymph nodes. {ECO:0000269|PubMed:17638845, ECO:0000269|PubMed:21289089}.; PTM: Has a high content of sialic acid and O-linked carbohydrate structures.; PTM: Cleavage by CTSG releases its extracellular domain and triggers its intramembrane proteolysis by gamma-secretase releasing the CD43 cytoplasmic tail chain (CD43-ct) which translocates to the nucleus. {ECO:0000269|PubMed:19696198}.; PTM: [CD43 cytoplasmic tail]: Sumoylated. {ECO:0000269|PubMed:19696198}.
uniprot
proteins
pubmed
11078605
uniprot
proteins
pubmed
11238599
uniprot
proteins
pubmed
11728336
uniprot
proteins
pubmed
17638845
uniprot
proteins
pubmed
18490738
uniprot
proteins
pubmed
18614175
uniprot
proteins
pubmed
19696198
uniprot
proteins
pubmed
1973410
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21289089
uniprot
proteins
pubmed
2144340
uniprot
proteins
pubmed
2347365
uniprot
proteins
pubmed
26700769
uniprot
proteins
pubmed
7514104
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, microvillus {ECO:0000250|UniProtKB:P13838}. Cell projection, uropodium {ECO:0000269|PubMed:21289089}. Note=Localizes to the uropodium and microvilli via its interaction with ERM proteins (EZR, RDX and MSN). {ECO:0000250|UniProtKB:P13838, ECO:0000269|PubMed:21289089}.; SUBCELLULAR LOCATION: [CD43 cytoplasmic tail]: Nucleus {ECO:0000269|PubMed:19696198}. Nucleus, PML body {ECO:0000269|PubMed:19696198}. Note=The sumoylated form localizes to the PML body. {ECO:0000269|PubMed:19696198}.
uniprot
proteins
transmembrane_region
TRANSMEM 249..271; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins