COMMD2
entrez
51122
canonical
uniprot
Q86X83
canonical
ensembl
ENSG00000114744
resolver
ensp
ENSP00000417962
resolver
ensp
ENSP00000419475
resolver
ensp
ENSP00000768120
resolver
enst
ENST00000491617
resolver
genesymbol
COMMD2
resolver
hgnc
HGNC:24993
resolver
uniprot
F8WBW1
resolver
uniprot
Q561V4
resolver
uniprot
Q9H3L5
resolver
uniprot
Q9Y5V1
resolver
uniprot_entry
COMD2_HUMAN
resolver
uniprot_entry
F8WBW1_HUMAN
resolver
uniprot_sec
Q561V4
resolver
uniprot_sec
Q9H3L5
resolver
uniprot_sec
Q9Y5V1
resolver
amino_acid_sequence
MLLELSEEHKEHLAFLPQVDSAVVAEFGRIAVEFLRRGANPKIYEGAARKLNVSSDTVQHGVEGLTYLLTESSKLMISELDFQDSVFVLGFSEELNKLLLQLYLDNRKEIRTILSELAPSLPSYHNLEWRLDVQLASRSLRQQIKPAVTIKLHLNQNGDHNTKVLQTDPATLLHLVQQLEQALEEMKTNHCRRVVRNIK
uniprot
proteins
function
FUNCTION: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129, ECO:0000305|PubMed:21778237}.
uniprot
proteins
mass_dalton
22745
uniprot
proteins
protein_family
COMM domain-containing protein 2 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15799966
uniprot
proteins
pubmed
21778237
uniprot
proteins
pubmed
23563313
uniprot
proteins
pubmed
23637203
uniprot
proteins
pubmed
25355947
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28892079
uniprot
proteins
pubmed
37172566
uniprot
proteins
pubmed
38459129
uniprot
proteins
pubmed
38504028
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21778237}.
uniprot
proteins