KRT16
entrez
3868
canonical
uniprot
P08779
canonical
ensembl
ENSG00000186832
resolver
ensp
ENSP00000301653
resolver
enst
ENST00000301653
resolver
genesymbol
KRT16
resolver
genesymbol_syn
KRT16A
resolver
hgnc
HGNC:6423
resolver
uniprot
A8K488
resolver
uniprot
P30654
resolver
uniprot
Q16402
resolver
uniprot
Q9UBG8
resolver
uniprot_entry
K1C16_HUMAN
resolver
uniprot_sec
A8K488
resolver
uniprot_sec
P30654
resolver
uniprot_sec
Q16402
resolver
uniprot_sec
Q9UBG8
resolver
amino_acid_sequence
MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPSTYGGGLSVSSRFSSGGACGLGGGYGGGFSSSSSFGSGFGGGYGGGLGAGFGGGLGAGFGGGFAGGDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPSEIKDYSPYFKTIEDLRNKIIAATIENAQPILQIDNARLAADDFRTKYEHELALRQTVEADVNGLRRVLDELTLARTDLEMQIEGLKEELAYLRKNHEEEMLALRGQTGGDVNVEMDAAPGVDLSRILNEMRDQYEQMAEKNRRDAETWFLSKTEELNKEVASNSELVQSSRSEVTELRRVLQGLEIELQSQLSMKASLENSLEETKGRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQSQEYQILLDVKTRLEQEIATYRRLLEGEDAHLSSQQASGQSYSSREVFTSSSSSSSRQTRPILKEQSSSSFSQGQSS
uniprot
proteins
disease_involvement
DISEASE: Pachyonychia congenita 1 (PC1) [MIM:167200]: An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present. {ECO:0000269|PubMed:10521820, ECO:0000269|PubMed:10606845, ECO:0000269|PubMed:10839714, ECO:0000269|PubMed:11359398, ECO:0000269|PubMed:11886499, ECO:0000269|PubMed:16250206, ECO:0000269|PubMed:17719747, ECO:0000269|PubMed:21160496, ECO:0000269|PubMed:21326300, ECO:0000269|PubMed:22668561, ECO:0000269|PubMed:24118415, ECO:0000269|PubMed:7539673}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Keratoderma, palmoplantar, non-epidermolytic, focal 1 (FNEPPK1) [MIM:613000]: A dermatological disorder characterized by non-epidermolytic palmoplantar keratoderma limited to the pressure points on the balls of the feet, with later mild involvement on the palms. Oral, genital and follicular keratotic lesions are often present. {ECO:0000269|PubMed:8595410}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in epithelial keratinocytes. Forms heteropolymers with type II keratins KRT6A and KRT6B, assembling into keratin intermediate filament networks that contribute to cytoskeletal resilience of palm, sole, nail bed and oral mucosa (PubMed:7539673, PubMed:8595410). Regulates epidermal innate immunity and inflammatory signaling in response to barrier disruption. Required for normal palmoplantar epidermal differentiation and nail unit structure (By similarity). {ECO:0000250|UniProtKB:Q9Z2K1, ECO:0000269|PubMed:7539673, ECO:0000269|PubMed:8595410}.
uniprot
proteins
mass_dalton
51268
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
10521820
uniprot
proteins
pubmed
10606845
uniprot
proteins
pubmed
10839714
uniprot
proteins
pubmed
10844556
uniprot
proteins
pubmed
11359398
uniprot
proteins
pubmed
11840567
uniprot
proteins
pubmed
11886499
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15731013
uniprot
proteins
pubmed
16250206
uniprot
proteins
pubmed
17719747
uniprot
proteins
pubmed
21160496
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21326300
uniprot
proteins
pubmed
22668561
uniprot
proteins
pubmed
24118415
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2431270
uniprot
proteins
pubmed
2451124
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26758872
uniprot
proteins
pubmed
7487986
uniprot
proteins
pubmed
7539673
uniprot
proteins
pubmed
8595410
uniprot
proteins
sequence_length
473
uniprot
proteins