Maf
entrez
17132
canonical
uniprot
P54843
canonical
ensembl
ENSMUSG00000055435
resolver
ensp
ENSMUSP00000104732
resolver
genesymbol
Maf
resolver
genesymbol_syn
Maf2
resolver
uniprot
Q3V1Z2
resolver
uniprot
Q4QY62
resolver
uniprot_entry
MAF_MOUSE
resolver
uniprot_sec
Q3V1Z2
resolver
uniprot_sec
Q4QY62
resolver
amino_acid_sequence
MASELAMNNSDLPTSPLAMEYVNDFDLMKFEVKKEPVETDRIISQCGRLIAGGSLSSTPMSTPCSSVPPSPSFSAPSPGSGSEQKAHLEDYYWMTGYPQQLNPEALGFSPEDAVEALISNSHQLQGGFDGYARGAQQLAAAAGAGAGASLGGSGEEMGPAAAVVSAVIAAAAAQSGAAPHYHHHHHHAAGHHHHPTAGAPGAAGGASASASGAGGAGGGGPASAGGGGGGGGGGGTAGAGGALHPHHAAGGLHFDDRFSDEQLVTMSVRELNRQLRGVSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHVLESEKNQLLQQVDHLKQEISRLVRERDAYKEKYEKLVSNGFRENGSSSDNPSSPEFFM
uniprot
proteins
function
FUNCTION: Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters (By similarity). Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf-responsive element binding. {ECO:0000250, ECO:0000269|PubMed:10097114, ECO:0000269|PubMed:10383433, ECO:0000269|PubMed:10403649, ECO:0000269|PubMed:10603348, ECO:0000269|PubMed:11943779, ECO:0000269|PubMed:14512017, ECO:0000269|PubMed:17823980, ECO:0000269|PubMed:17897790, ECO:0000269|PubMed:17901057, ECO:0000269|PubMed:19143053, ECO:0000269|PubMed:9070273, ECO:0000269|PubMed:9566892}.
uniprot
proteins
mass_dalton
38435
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="S->A: Inhibition on transcriptional activation on CD13 proximal promoter in endothelial cells."; /evidence="ECO:0000269|PubMed:17897790"; MUTAGEN 70; /note="S->A: No effect on transcriptional activation on CD13 proximal promoter. Increases liver specific transactivation on the IL-4 promoter."; /evidence="ECO:0000269|PubMed:17897790"; MUTAGEN 334; /note="L->P: Abolishes interaction with USF2."; /evidence="ECO:0000269|PubMed:9070273
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is triggered by glucocorticoids (By similarity). {ECO:0000250}.; PTM: Phosphorylated by GSK3 and MAPK13 on serine and threonine residues (By similarity). The phosphorylation status can serve to either stimulate or inhibit transcription. {ECO:0000250}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
Maf subfamily
uniprot
proteins
pubmed
10097114
uniprot
proteins
pubmed
10383433
uniprot
proteins
pubmed
10403649
uniprot
proteins
pubmed
10603348
uniprot
proteins
pubmed
11943779
uniprot
proteins
pubmed
14512017
uniprot
proteins
pubmed
14707122
uniprot
proteins
pubmed
15249232
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17823980
uniprot
proteins
pubmed
17897790
uniprot
proteins
pubmed
17901057
uniprot
proteins
pubmed
19143053
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7799931
uniprot
proteins
pubmed
9070273
uniprot
proteins
pubmed
9566892
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins