Fcgrt
entrez
14132
canonical
uniprot
Q61559
canonical
ensembl
ENSMUSG00000003420
resolver
ensp
ENSMUSP00000003512
resolver
ensp
ENSMUSP00000147496
resolver
enst
ENSMUST00000003512
resolver
enst
ENSMUST00000210642
resolver
genesymbol
Fcgrt
resolver
genesymbol_syn
Fcrn
resolver
uniprot
A0A1B0GRF2
resolver
uniprot
Q6PKB0
resolver
uniprot
Q9QUR0
resolver
uniprot
Q9R2A5
resolver
uniprot_entry
A0A1B0GRF2_MOUSE
resolver
uniprot_entry
FCGRN_MOUSE
resolver
uniprot_entry
Q6PKB0_MOUSE
resolver
uniprot_sec
Q9QUR0
resolver
uniprot_sec
Q9R2A5
resolver
amino_acid_sequence
MGMPLPWALSLLLVLLPQTWGSETRPPLMYHLTAVSNPSTGLPSFWATGWLGPQQYLTYNSLRQEADPCGAWMWENQVSWYWEKETTDLKSKEQLFLEALKTLEKILNGTYTLQGLLGCELASDNSSVPTAVFALNGEEFMKFNPRIGNWTGEWPETEIVANLWMKQPDAARKESEFLLNSCPERLLGHLERGRRNLEWKEPPSMRLKARPGNSGSSVLTCAAFSFYPPELKFRFLRNGLASGSGNCSTGPNGDGSFHAWSLLEVKRGDEHHYQCQVEHEGLAQPLTVDLDSSARSSVPVVGIVLGLLLVVVAIAGGVLLWGRMRSGLPAPWLSLSGDDSGDLLPGGNLPPEAEPQGANAFPATS
uniprot
proteins
function
FUNCTION: Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7504013). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB. {ECO:0000250|UniProtKB:P55899, ECO:0000269|PubMed:7504013}.
uniprot
proteins
mass_dalton
40093
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7504013
uniprot
proteins
pubmed
7538537
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P13599}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:P55899}.
uniprot
proteins
transmembrane_region
TRANSMEM 298..321; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins