Cnp
entrez
25275
canonical
uniprot
P13233
canonical
ensembl
ENSRNOG00000017496
resolver
ensembl
ENSRNOG00055033417
resolver
ensembl
ENSRNOG00060027890
resolver
ensembl
ENSRNOG00065032747
resolver
ensp
ENSRNOP00000080276
resolver
ensp
ENSRNOP00055047679
resolver
ensp
ENSRNOP00060040463
resolver
ensp
ENSRNOP00065046395
resolver
enst
ENSRNOT00055057794
resolver
enst
ENSRNOT00060048548
resolver
enst
ENSRNOT00065056380
resolver
genesymbol
Cnp
resolver
genesymbol_syn
Cnp1
resolver
uniprot
Q4V796
resolver
uniprot
Q64575
resolver
uniprot_entry
CN37_RAT
resolver
uniprot_sec
Q4V796
resolver
uniprot_sec
Q64575
resolver
amino_acid_sequence
MSTSFARKSHTFLPKIFFRKMSSSGAKDKPELQFPFLQDEDTVATLHECKTLFILRGLPGSGKSTLARLIVEKYHNGTKMVSADAYKIIPGSRADFSEEYKRLDEDLAGYCRRDIRVLVLDDTNHERERLDQLFEMADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSLDDLKKLKPGLEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFISGDEPKEKLDLVSYFGKRPPGVLHCTTKFCDYGKATGAEEYAQQDVVRRSYGKAFKLSISALFVTPKTAGAQVVLNEQELQLWPSDLDKPSSSESLPPGSRAHVTLGCAADVQPVQTGLDLLEILQQVKGGSQGEEVGELPRGKLYSLGKGRWMLSLAKKMEVKAIFTGYYGKGKPVPVHGSRKGGAMQICTII
uniprot
proteins
ec_number
3.1.4.37
uniprot
proteins
function
FUNCTION: Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. In the mitochondria, regulates the functioning of the mitochondrial permeability transition pore (mPTP), and thus is involved in the mechanisms of cell death, both apoptosis and necrosis. Acts as an antiviral factor by suppressing the assembly of SARS-CoV-2 virions. {ECO:0000250|UniProtKB:P06623, ECO:0000250|UniProtKB:P09543, ECO:0000250|UniProtKB:P16330}.
uniprot
proteins
mass_dalton
47268
uniprot
proteins
mutagenesis
MUTAGEN 250; /note="H->L: Reduces activity 15000-fold."; /evidence="ECO:0000269|PubMed:12947117"; MUTAGEN 252; /note="T->A: Reduces activity 100-fold."; /evidence="ECO:0000269|PubMed:12947117"; MUTAGEN 329; /note="H->L: Reduces activity 15000-fold."; /evidence="ECO:0000269|PubMed:12947117"; MUTAGEN 331; /note="T->A: Reduces activity 700-fold."; /evidence="ECO:0000269|PubMed:12947117"; MUTAGEN 344; /note="G->A: Alters secondary structure and lowers activity."; /evidence="ECO:0000269|PubMed:12947117"; MUTAGEN 417; /note="C->S: Abolishes binding to myelin."; /evidence="ECO:0000269|PubMed:7884818
uniprot
proteins
post_translational_modification
PTM: Acetylated. Acetylation suppresses enzymatic activity through restricting substrate accessibility. Deacetylated by SIRT3. {ECO:0000250|UniProtKB:P09543}.
uniprot
proteins
protein_family
2H phosphoesterase superfamily
uniprot
proteins
protein_family
CNPase family
uniprot
proteins
pubmed
12947117
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
3040924
uniprot
proteins
pubmed
7884818
uniprot
proteins
pubmed
7932861
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Melanosome {ECO:0000250|UniProtKB:P09543}. Mitochondrion {ECO:0000250|UniProtKB:P09543}. Note=Firmly bound to membrane structures of brain white matter. {ECO:0000250|UniProtKB:P16330}.
uniprot
proteins