Bcap31
entrez
27061
canonical
uniprot
Q61335
canonical
ensembl
ENSMUSG00000002015
resolver
ensp
ENSMUSP00000002091
resolver
ensp
ENSMUSP00000309336
resolver
ensp
ENSMUSP00000309337
resolver
ensp
ENSMUSP00000350913
resolver
enst
ENSMUST00000002091
resolver
genesymbol
Bcap31
resolver
genesymbol_syn
Bap31
resolver
uniprot
A2ALM8
resolver
uniprot
Q9D0E9
resolver
uniprot
Q9D8G7
resolver
uniprot_entry
BAP31_MOUSE
resolver
uniprot_sec
A2ALM8
resolver
uniprot_sec
Q9D0E9
resolver
uniprot_sec
Q9D8G7
resolver
amino_acid_sequence
MSLQWTTVATFLYAEVFAVLLLCIPFISPKRWQKVFKSRLVELVVTYGNTFFVVLIVILVLLVIDAVREILKYDDVTEKVNLQNNPGAMEHFHMKLFRAQRNLYIAGFSLLLSFLLRRLVTLISQQATLLASNEAFKKQAESASEAAKKYMEENDQLKKGAAEDGDKLDIGNTEMKLEENKSLKNDLRKLKDELASTKKKLEKAENEALAMQKQSEGLTKEYDRLLEEHAKLQASVRGPSVKKEE
uniprot
proteins
function
FUNCTION: Functions as a chaperone protein (PubMed:9396746). Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:9396746). Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:9396746). Also serves as a cargo receptor for the export of transmembrane proteins (PubMed:15187134). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (By similarity). In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (By similarity). May be involved in CASP8-mediated apoptosis (By similarity). {ECO:0000250|UniProtKB:P51572, ECO:0000269|PubMed:15187134, ECO:0000269|PubMed:9396746}.
uniprot
proteins
mass_dalton
27957
uniprot
proteins
post_translational_modification
PTM: Cleaved by CASP8 and other caspases. {ECO:0000250}.
uniprot
proteins
protein_family
BCAP29/BCAP31 family
uniprot
proteins
pubmed
15187134
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8070407
uniprot
proteins
pubmed
8612576
uniprot
proteins
pubmed
9396746
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P51572}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:P51572}; Multi-pass membrane protein {ECO:0000255}. Note=May shuttle between the ER and the intermediate compartment/cis-Golgi complex. Associates with the mitochondria-associated endoplasmic reticulum membrane via interaction with TOMM40. {ECO:0000250|UniProtKB:P51572}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 44..64; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins