Etaa1
entrez
68145
canonical
uniprot
Q5SVT3
canonical
ensembl
ENSMUSG00000016984
resolver
ensp
ENSMUSP00000075957
resolver
genesymbol
Etaa1
resolver
uniprot
Q8BZM6
resolver
uniprot
Q8K332
resolver
uniprot
Q9CS19
resolver
uniprot
Q9D2Z9
resolver
uniprot_entry
ETAA1_MOUSE
resolver
uniprot_sec
Q8BZM6
resolver
uniprot_sec
Q8K332
resolver
uniprot_sec
Q9CS19
resolver
uniprot_sec
Q9D2Z9
resolver
amino_acid_sequence
MQLKDGGTGMSRRRKHADSPARRSTPHRAAAKNCRPAAEPWLRESRAACSSQLRRAGTRSARRAQRQAAADGGRSPRGKETPVQIVKMDLLSCTFSSPNDPDGQTDIFWDQNSPMTKQLGKGRKKQISSAYSDEISHIVNRIAPQDEKPVTNSMLGVWIGETAIPCTPGVAKEKSRVKASCTKLKTKNREKELMKLAQQFDKNMEELDVIQEQDGKNHDFIQMTSKMGHLDNHKDSVQKPSGDVVPEITCTPVKKQMKGDSRISLAKAQDSSQKPFDQNVEAAFNAIFDGSTQMCSGQLSQDLLDAFLNNSKTSLRKKNALLQEEIITTETLLTENLLNKTPISLSPQIDTTVILNSCVTPCPKTPAAPDTQLDELTANDFEDDWESLLGSEPFLMENAEMLEFVPSTTAQDTCQKAICTSVGENDTITSRTNMNLGGRLRDSKVTLDLPSKTRNGELRNAGEHRFSSHPGDESRKVPFTGNKVSFEKSVTSIVSKDEDYVAVSNLEKVKEDSRNKCILNKHSSNKSSSYTRYPSKQSSELGVNLPLQVPTTDPFDSVFLGKENIVCSTNQSHGSKLNSSFDDWNDPLLASEMVEACHRLEATWDAGEVDDDLFCQACDDIERLTQQENKGSEESESVSYTSTRGSRSSSTASKQASQSAPSKHWNVVSSAVPLSLANKSQMSKPVTVQKRGRCGDGPNILDATNLSVCSKNSSDNKRGPVQVNSSKFVLGGSSNLNVNLGLMSTKIATNMKLSTQQLSHNSLADTAQNDNKILKLPKFTFKKKNPQLNQNHLVGSVPVGKISEDLGKRETVNSLLEANQQQSSINYSESLKPSSPDEEERNRKYSPEEIQRKRQEALVRRKAKALHTVQSAPISLP
uniprot
proteins
function
FUNCTION: Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets. {ECO:0000250|UniProtKB:Q9NY74}.
uniprot
proteins
mass_dalton
96552
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ATR. {ECO:0000250|UniProtKB:Q9NY74}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
877
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NY74}. Note=Localizes at sites of DNA damage following replication stress. Recruited to stalled replication forks via interaction with RPA1 and RPA2 subunits of the RPA complex. {ECO:0000250|UniProtKB:Q9NY74}.
uniprot
proteins