Pramel7
entrez
347712
canonical
uniprot
Q810Y8
canonical
ensembl
ENSMUSG00000025839
resolver
ensp
ENSMUSP00000026957
resolver
enst
ENSMUST00000026957
resolver
genesymbol
Pramel7
resolver
uniprot
Q7TPY5
resolver
uniprot_entry
PRAL7_MOUSE
resolver
uniprot_sec
Q7TPY5
resolver
amino_acid_sequence
MVSAPPTLQDQAFRSLVRNEVLTVSDAECLIREFFPPLFKEASTQKKPKTIMILVEHWPYPCLHVGLLIDKPNFQIFQAILDGVDTWLKRKYRPRMGRLKKVDFRDAQHHASLDMQDEREGRDYLVGTLPKKQIVEDHSRTRKERLKLFHDLSFMSSLHEDKHQTLLLEWAKERTSFLHLCCEKLEIGAVEVSKVRNVLKFLQPELIKELKLNTVGNLSKLAKFVPFIRKMRNLQKLMLVRTFGTRTFTQEEKQNISKIISLFCKLSCLRHLTIDDVYFLTDQMKELLRCLEAPLVSLKITLCQLSQSDLESFAQRWNYSQLKHLCLRGVTLTNLDVTPLRDFLKRVAANLQTLDLEDCRMDDSHFRTLLPALIKCTQLTSINLYDNDISEDVLENFLHRTTNLSQLTTEMYPAPSEVYNESNYVIVEIFIQICSELMNKLMEVRQANSVCFGSSSCYDCDNRYLYEDDGDVTLCLCQE
uniprot
proteins
function
FUNCTION: Promotes maintenance and self-renewal of pluripotent embryonic stem cells (ESCs), downstream of LIF/STAT3 (PubMed:21425410). Maintains the pluripotency state of ESCs by repressing DNA methylation through the regulation of UHRF1 stability. Mediates the proteasomal degradation of UHRF1. Is required for the establishment of the blastocyst (PubMed:28604677). {ECO:0000269|PubMed:21425410, ECO:0000269|PubMed:28604677}.
uniprot
proteins
mass_dalton
55834
uniprot
proteins
protein_family
PRAME family
uniprot
proteins
pubmed
12620990
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21425410
uniprot
proteins
pubmed
28604677
uniprot
proteins
sequence_length
479
uniprot
proteins