CD180
entrez
4064
canonical
uniprot
Q99467
canonical
ensembl
ENSG00000134061
resolver
ensp
ENSP00000256447
resolver
enst
ENST00000256447
resolver
genesymbol
CD180
resolver
genesymbol_syn
LY64
resolver
genesymbol_syn
RP105
resolver
hgnc
HGNC:6726
resolver
uniprot
B2R7Z7
resolver
uniprot
Q32MM5
resolver
uniprot_entry
CD180_HUMAN
resolver
uniprot_sec
B2R7Z7
resolver
uniprot_sec
Q32MM5
resolver
amino_acid_sequence
MAFDVSCFFWVVLFSAGCKVITSWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKLSCGITAIGIFFLIVFLLLLAILLFFAVKYLLRWKYQHI
uniprot
proteins
function
FUNCTION: Pattern recognition receptor predominantly expressed on B-cells, dendritic cells, and certain monocytes/macrophages, structurally resembling Toll-like receptors (TLRs) that plays a role in modulating immune responses (PubMed:15852007). While ressembling a TLR, lacks the intracellular TIR (Toll/IL-1R) signaling domain and thus does not directly transduce signals. Instead, modulates immune responses, often in conjunction with other TLRs. For example, in cooperation with MD-1/LY86, interacts directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligand (PubMed:15852007). {ECO:0000269|PubMed:15852007}.
uniprot
proteins
mass_dalton
74179
uniprot
proteins
protein_family
Toll-like receptor family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15852007
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21959264
uniprot
proteins
pubmed
8975706
uniprot
proteins
pubmed
9763566
uniprot
proteins
sequence_length
661
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 627..650; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins