CLEC2B
entrez
9976
canonical
uniprot
Q92478
canonical
ensembl
ENSG00000110852
resolver
ensp
ENSP00000228438
resolver
ensp
ENSP00000563562
resolver
ensp
ENSP00000563563
resolver
ensp
ENSP00000563564
resolver
ensp
ENSP00000563565
resolver
ensp
ENSP00000563566
resolver
ensp
ENSP00000635005
resolver
enst
ENST00000228438
resolver
enst
ENST00000893503
resolver
enst
ENST00000893504
resolver
enst
ENST00000893505
resolver
enst
ENST00000893506
resolver
enst
ENST00000893507
resolver
enst
ENST00000964946
resolver
genesymbol
CLEC2B
resolver
genesymbol_syn
AICL
resolver
genesymbol_syn
CLECSF2
resolver
genesymbol_syn
IFNRG1
resolver
hgnc
HGNC:2053
resolver
uniprot
B2R9U1
resolver
uniprot
Q8IZE9
resolver
uniprot
Q9BS74
resolver
uniprot
Q9UQB4
resolver
uniprot_entry
CLC2B_HUMAN
resolver
uniprot_sec
B2R9U1
resolver
uniprot_sec
Q8IZE9
resolver
uniprot_sec
Q9BS74
resolver
uniprot_sec
Q9UQB4
resolver
amino_acid_sequence
MMTKHKKCFIIVGVLITTNIITLIVKLTRDSQSLCPYDWIGFQNKCYYFSKEEGDWNSSKYNCSTQHADLTIIDNIEEMNFLRRYKCSSDHWIGLKMAKNRTGQWVDGATFTKSFGMRGSEGCAYLSDDGAATARCYTERKWICRKRIH
uniprot
proteins
function
FUNCTION: Membrane-bound protein expressed on myeloid cells which acts as a ligand to stimulate the activating receptor NKp80/KLRF1, expressed on the surface of natural killer (NK) cells. In turn, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. {ECO:0000269|PubMed:17057721, ECO:0000269|PubMed:18230726, ECO:0000269|PubMed:23929856}.
uniprot
proteins
mass_dalton
17307
uniprot
proteins
mutagenesis
MUTAGEN 87; /note="C->S: Complete loss of dimerization."; /evidence="ECO:0000269|PubMed:29980609
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Ubiquitinated by human herpesvirus 8 protein K5, leading to endolysosomal degradation. {ECO:0000269|PubMed:18230726}.; PTM: N-linked glycosylated; required to enable surface expression and the extent of surface expression correlates with the number of functional conventional N-glycosylation sites. {ECO:0000269|PubMed:29980609}.
uniprot
proteins
pubmed
10072769
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17057721
uniprot
proteins
pubmed
18230726
uniprot
proteins
pubmed
23929856
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29980609
uniprot
proteins
pubmed
9038101
uniprot
proteins
sequence_length
149
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23929856, ECO:0000269|PubMed:29980609}; Single-pass type II membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:23929856}. Note=Resting NK cells contain intracellular stores of CLEC2B associated with the Golgi complex. {ECO:0000269|PubMed:23929856}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..25; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins