PRDX4
entrez
10549
canonical
uniprot
Q13162
canonical
ensembl
ENSG00000123131
resolver
ensp
ENSP00000368646
resolver
enst
ENST00000379341
resolver
genesymbol
HEL-S-97n
resolver
genesymbol
PRDX4
resolver
genesymbol_syn
PRDX4
resolver
hgnc
HGNC:17169
resolver
uniprot
Q6FHT3
resolver
uniprot
V9HW63
resolver
uniprot_entry
PRDX4_HUMAN
resolver
uniprot_entry
V9HW63_HUMAN
resolver
uniprot_sec
Q6FHT3
resolver
amino_acid_sequence
MEALPLLAATTPDHGRHRRLLLLPLLLFLLPAGAVQGWETEERPRTREEECHFYAGGQVYPGEASRVSVADHSLHLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLTHQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN
uniprot
proteins
ec_number
1.11.1.24
uniprot
proteins
function
FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. {ECO:0000269|PubMed:9388242}.
uniprot
proteins
mass_dalton
30540
uniprot
proteins
post_translational_modification
PTM: The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond. {ECO:0000269|PubMed:12059788, ECO:0000269|PubMed:21916849}.
uniprot
proteins
protein_family
AhpC/Prx1 subfamily
uniprot
proteins
protein_family
Peroxiredoxin family
uniprot
proteins
pubmed
12059788
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18052930
uniprot
proteins
pubmed
19892738
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21916849
uniprot
proteins
pubmed
21994946
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9388242
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18052930, ECO:0000269|PubMed:9388242}. Endoplasmic reticulum {ECO:0000269|PubMed:18052930}. Note=Cotranslationally translocated to and retained within the endoplasmic reticulum. A small fraction of the protein is cytoplasmic. {ECO:0000269|PubMed:18052930}.
uniprot
proteins