ELOF1
entrez
84337
canonical
uniprot
P60002
canonical
ensembl
ENSG00000130165
resolver
ensp
ENSP00000252445
resolver
ensp
ENSP00000465765
resolver
ensp
ENSP00000467264
resolver
ensp
ENSP00000467330
resolver
ensp
ENSP00000467914
resolver
ensp
ENSP00000560202
resolver
ensp
ENSP00000560203
resolver
ensp
ENSP00000560204
resolver
ensp
ENSP00000560205
resolver
ensp
ENSP00000560206
resolver
ensp
ENSP00000560207
resolver
ensp
ENSP00000560208
resolver
ensp
ENSP00000560209
resolver
ensp
ENSP00000560210
resolver
ensp
ENSP00000560211
resolver
ensp
ENSP00000591410
resolver
ensp
ENSP00000591411
resolver
ensp
ENSP00000591413
resolver
ensp
ENSP00000591414
resolver
ensp
ENSP00000591415
resolver
ensp
ENSP00000591416
resolver
ensp
ENSP00000591417
resolver
ensp
ENSP00000591418
resolver
ensp
ENSP00000617544
resolver
ensp
ENSP00000617545
resolver
ensp
ENSP00000617546
resolver
ensp
ENSP00000617547
resolver
enst
ENST00000252445
resolver
enst
ENST00000586120
resolver
enst
ENST00000587806
resolver
enst
ENST00000590700
resolver
enst
ENST00000591674
resolver
enst
ENST00000890143
resolver
enst
ENST00000890144
resolver
enst
ENST00000890145
resolver
enst
ENST00000890146
resolver
enst
ENST00000890147
resolver
enst
ENST00000890148
resolver
enst
ENST00000890149
resolver
enst
ENST00000890150
resolver
enst
ENST00000890151
resolver
enst
ENST00000890152
resolver
enst
ENST00000921351
resolver
enst
ENST00000921352
resolver
enst
ENST00000921354
resolver
enst
ENST00000921355
resolver
enst
ENST00000921356
resolver
enst
ENST00000921357
resolver
enst
ENST00000921358
resolver
enst
ENST00000921359
resolver
enst
ENST00000947485
resolver
enst
ENST00000947486
resolver
enst
ENST00000947487
resolver
enst
ENST00000947488
resolver
genesymbol
ELOF1
resolver
hgnc
HGNC:28691
resolver
uniprot
Q8R1J7
resolver
uniprot
Q96II4
resolver
uniprot_entry
ELOF1_HUMAN
resolver
uniprot_sec
Q8R1J7
resolver
uniprot_sec
Q96II4
resolver
amino_acid_sequence
MGRRKSKRKPPPKKKMTGTLETQFTCPFCNHEKSCDVKMDRARNTGVISCTVCLEEFQTPITYLSEPVDVYSDWIDACEAANQ
uniprot
proteins
function
FUNCTION: Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (PubMed:34108662, PubMed:34108663, PubMed:38316879). Acts as a key adapter required to anchor TC-NER factors to RNA polymerase II: stably positions UVSSA and the DCX(ERCC8) complex (also named CSA complex) on arrested RNA polymerase II, leading to neddylation and activation of the DCX(ERCC8) complex and ubiquitination of RNA polymerase II (PubMed:38316879). {ECO:0000269|PubMed:34108662, ECO:0000269|PubMed:34108663, ECO:0000269|PubMed:38316879}.
uniprot
proteins
mass_dalton
9462
uniprot
proteins
mutagenesis
MUTAGEN 30..32; /note="NHE->AAA: Abolished interaction with the DCX(ERCC8) complex, leading to defects in transcription-coupled nucleotide excision repair (TC-NER)."; /evidence="ECO:0000269|PubMed:38316879"; MUTAGEN 55; /note="E->A: Does not affect transcription-coupled nucleotide excision repair (TC-NER); when associated with A-79."; /evidence="ECO:0000269|PubMed:38316879"; MUTAGEN 72..73; /note="SD->AA: Reduced interaction with RNA polymerase II."; /evidence="ECO:0000269|PubMed:34108663"; MUTAGEN 79; /note="E->A: Does not affect transcription-coupled nucleotide excision repair (TC-NER); when associated with A-55."; /evidence="ECO:0000269|PubMed:38316879
uniprot
proteins
protein_family
ELOF1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
34108662
uniprot
proteins
pubmed
34108663
uniprot
proteins
pubmed
38316879
uniprot
proteins
sequence_length
83
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34108662}. Chromosome {ECO:0000269|PubMed:34108662}. Note=Associates to RNA polymerase II (Pol II). {ECO:0000269|PubMed:34108662}.
uniprot
proteins