AMER2
entrez
219287
canonical
uniprot
Q8N7J2
canonical
ensembl
ENSG00000165566
resolver
ensp
ENSP00000350469
resolver
ensp
ENSP00000426528
resolver
genesymbol
AMER2
resolver
genesymbol_syn
FAM123A
resolver
hgnc
HGNC:26360
resolver
uniprot
Q5RL80
resolver
uniprot
Q5VX56
resolver
uniprot
Q8N593
resolver
uniprot
Q96NN5
resolver
uniprot_entry
AMER2_HUMAN
resolver
uniprot_sec
Q5RL80
resolver
uniprot_sec
Q5VX56
resolver
uniprot_sec
Q8N593
resolver
uniprot_sec
Q96NN5
resolver
amino_acid_sequence
METSRSRGGGGAVSERGGAGASVGVCRRKAEAGAGTGTLAADMDLHCDCAAETPAAEPPSGKINKAAFKLFKKRKSGGTMPSIFGVKNKGDGKSSGPTGLVRSRTHDGLAEVLVLESGRKEEPRGGGDSGGGGGGRPNPGPPRAAGPGGGSLASSSVAKSHSFFSLLKKNGRSENGKGEPVDASKAGGKQKRGLRGLFSGMRWHRKDKRAKAEAAEGRAPGGGLILPGSLTASLECVKEETPRAAREPEEPSQDAPRDPAGEPAGGEEVPAPADRAPARSCREAEGLAHPGDTGARGEDAAGHRRAEPGPGEVRTAEDASRTGAVPVKTVPLVDSEGGSGRAPAAPDPASVDPPSDPSADRICLMFSDVTSLKSFDSLTGCGDIIADQEEEAGPSCDKHVPGPGKPALSKKNPGVVAYQGGGEEMASPDEVDDTYLQEFWDMLSQTEEQGPEPQEGAAKVAAALETKVVPETPKDTRCVEAAKDASSVKRRRLNRIPIEPHPKEEPKHPEKEQQEGVPNSDEGYWDSTTPGPEEDSSSSGKKAGIPRDSYSGDALYDLYADPDGSPATLPGGKDNEETSSLSRLKPVSPGTITCPLRTPGSLLKDSKIPISIKHLTNLPSSHPVVHQQPSRSEMPRTKIPVSKVLVRRVSNRGLAGTTIRATACHDSAKKL
uniprot
proteins
function
FUNCTION: Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. {ECO:0000269|PubMed:22128170}.
uniprot
proteins
mass_dalton
69507
uniprot
proteins
protein_family
Amer family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17925383
uniprot
proteins
pubmed
20843316
uniprot
proteins
pubmed
22128170
uniprot
proteins
sequence_length
671
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22128170}; Peripheral membrane protein {ECO:0000269|PubMed:22128170}. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2.
uniprot
proteins