Cbr3
entrez
304078
canonical
uniprot
B2GV72
canonical
ensembl
ENSRNOG00000001701
resolver
ensp
ENSRNOP00000002310
resolver
enst
ENSRNOT00000002310
resolver
genesymbol
Cbr3
resolver
uniprot_entry
CRB3_RAT
resolver
amino_acid_sequence
MSSCSRVALVTGANKGIGFAITRDLCRKFSGDVVLTARDEARGRAAVKQLQAEGLSPRFHQLDIDNPQSIRALRDFLRKEYGGLNVLVNNAGIAFRMDDPTPFDVQAEVTLKTNFFATRNVCTELLPIMKPHGRVVNVSSLQGLKALENCSEDLQERFRCDTLTEGDLVDLMKKFVEDTKNEVHEREGWPDSAYGVSKLGVTVLTRILARQLDEKRKADRILLNACCPGWVKTDMARDQGSRTVEEGAETPVYLALLPPDATEPHGQLVRDKVVQTW
uniprot
proteins
ec_number
1.1.1.184
uniprot
proteins
ec_number
1.6.5.10
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity (PubMed:18983987). Acts on several orthoquinones, as well as on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified (By similarity). {ECO:0000250|UniProtKB:O75828, ECO:0000269|PubMed:18983987}.
uniprot
proteins
mass_dalton
30841
uniprot
proteins
mutagenesis
MUTAGEN 230; /note="W->P: Does not affect carbonyl reductase (NADPH) activity."; /evidence="ECO:0000269|PubMed:18983987
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18983987
uniprot
proteins
sequence_length
277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O75828}.
uniprot
proteins