PRMT6
entrez
55170
canonical
uniprot
Q96LA8
canonical
ensembl
ENSG00000198890
resolver
ensp
ENSP00000359095
resolver
genesymbol
PRMT6
resolver
genesymbol_syn
HRMT1L6
resolver
hgnc
HGNC:18241
resolver
uniprot
A3KME1
resolver
uniprot
B4DID8
resolver
uniprot
Q5T5Y5
resolver
uniprot
Q6DKI4
resolver
uniprot
Q9NVR8
resolver
uniprot_entry
ANM6_HUMAN
resolver
uniprot_sec
A3KME1
resolver
uniprot_sec
B4DID8
resolver
uniprot_sec
Q5T5Y5
resolver
uniprot_sec
Q6DKI4
resolver
uniprot_sec
Q9NVR8
resolver
amino_acid_sequence
MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED
uniprot
proteins
ec_number
2.1.1.319
uniprot
proteins
function
FUNCTION: Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910, PubMed:30420520). Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910). Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (PubMed:17898714, PubMed:18077460, PubMed:18079182). H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (PubMed:17898714, PubMed:18077460). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:19509293). Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (PubMed:16600869). Methylates HMGA1 (PubMed:16157300, PubMed:16159886). Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (By similarity). May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC) (PubMed:17267505). Methylates GPS2, protecting GPS2 from ubiquitination and degradation (By similarity). Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (PubMed:30420520). {ECO:0000250|UniProtKB:Q6NZB1, ECO:0000269|PubMed:11724789, ECO:0000269|PubMed:16157300, ECO:0000269|PubMed:16159886, ECO:0000269|PubMed:16600869, ECO:0000269|PubMed:17267505, ECO:0000269|PubMed:17898714, ECO:0000269|PubMed:18077460, ECO:0000269|PubMed:18079182, ECO:0000269|PubMed:19405910, ECO:0000269|PubMed:19509293, ECO:0000269|PubMed:20047962, ECO:0000269|PubMed:30420520}.
uniprot
proteins
mass_dalton
41938
uniprot
proteins
mutagenesis
MUTAGEN 35; /note="R->A: Inhibits automethylation but does not affect methylation of other proteins. Reduces protein stability."; /evidence="ECO:0000269|PubMed:23866860"; MUTAGEN 86..88; /note="VLD->KLA: In PRMT6dn; abolishes histone methyltransferase H3R2me2a and transcriptional coactivator activities and reduces protein stability. This mutation abolishes automethylation."; /evidence="ECO:0000269|PubMed:17898714, ECO:0000269|PubMed:20047962, ECO:0000269|PubMed:23866860, ECO:0000269|PubMed:30420520"; MUTAGEN 369; /note="K->R: Resistant to degradation."; /evidence="ECO:0000269|PubMed:32828318
uniprot
proteins
post_translational_modification
PTM: Automethylation enhances its stability and antiretroviral activity.; PTM: Ubiquitinated by the SCF-FBXO24 E3 ubiquitin ligase, leading to proteasomal degradation. {ECO:0000269|PubMed:32828318}.
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
PRMT6 subfamily
uniprot
proteins
protein_family
Protein arginine N-methyltransferase family
uniprot
proteins
pubmed
11724789
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15334060
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15596808
uniprot
proteins
pubmed
16157300
uniprot
proteins
pubmed
16159886
uniprot
proteins
pubmed
16600869
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17176473
uniprot
proteins
pubmed
17267505
uniprot
proteins
pubmed
17415034
uniprot
proteins
pubmed
17898714
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18077460
uniprot
proteins
pubmed
18079182
uniprot
proteins
pubmed
18263580
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19405910
uniprot
proteins
pubmed
19509293
uniprot
proteins
pubmed
20047962
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23866860
uniprot
proteins
pubmed
26178996
uniprot
proteins
pubmed
30420520
uniprot
proteins
pubmed
32828318
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11724789}.
uniprot
proteins