SUCNR1
entrez
56670
canonical
uniprot
Q9BXA5
canonical
ensembl
ENSG00000198829
resolver
ensp
ENSP00000355156
resolver
ensp
ENSP00000545387
resolver
ensp
ENSP00000613298
resolver
enst
ENST00000362032
resolver
enst
ENST00000875328
resolver
enst
ENST00000943239
resolver
genesymbol
SUCNR1
resolver
genesymbol_syn
GPR91
resolver
hgnc
HGNC:4542
resolver
uniprot
A8K305
resolver
uniprot
Q8TDQ8
resolver
uniprot_entry
SUCR1_HUMAN
resolver
uniprot_sec
A8K305
resolver
uniprot_sec
Q8TDQ8
resolver
amino_acid_sequence
MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated (By similarity) (PubMed:15141213, PubMed:23770096, PubMed:34133934). Succinate-SUCNR1 signaling serves as a link between metabolic stress, inflammation and energy homeostasis (PubMed:18820681, PubMed:34133934). In macrophages, plays a range of immune-regulatory roles. During inflammation, succinate-SUCNR1 signaling may act as an anti-inflammatory mediator or boost inflammation depending on the inflammatory status of cells (By similarity). Hyperpolarizes M2 macrophages versus M1 phenotype through Gq signaling by regulating the transcription of genes involved in immune function (PubMed:34133934). In activated M1 macrophages, plays a pro-inflammatory role in response to LPS (By similarity). Expressed in dendritic cells, where it is involved in the sensing of immunological danger and enhances immunity. Mediates succinate triggered intracelleular calcium mobilization, induces migratory responses and acts in synergy with Toll-like receptor ligands for the production of proinflammatory cytokines as well as an enhancement of antigen-specific activation of helper T cells (PubMed:18820681). In the small intestine, mediates the activation of tuft cells by dietary succinate and triggers type 2 immunity (By similarity). In adipocytes, plays an important role in the control of energy metabolism. In response to succinate, controls leptin expression in an AMPK-JNK-CEBPA-dependent as well as circadian clock-regulated manner (By similarity). In muscle tissue, is expressed in non-muscle cells and coordinates muscle remodeling in response to the succinate produced during exercise training in a paracrine manner (By similarity). In retina, acts as a mediator of vessel growth during retinal development. In response to succinate, regulates the production of angiogenic factors, including VEGF, by retinal ganglion neurons (By similarity). {ECO:0000250|UniProtKB:Q6IYF9, ECO:0000250|UniProtKB:Q99MT6, ECO:0000269|PubMed:15141213, ECO:0000269|PubMed:18820681, ECO:0000269|PubMed:23770096, ECO:0000269|PubMed:34133934}.
uniprot
proteins
mass_dalton
38698
uniprot
proteins
mutagenesis
MUTAGEN 99; /note="R->A: Abolishes activation by succinate."; /evidence="ECO:0000269|PubMed:15141213"; MUTAGEN 103; /note="H->A: Abolishes activation by succinate."; /evidence="ECO:0000269|PubMed:15141213"; MUTAGEN 107; /note="Y->F: No effect on receptor function."; /evidence="ECO:0000269|PubMed:15141213"; MUTAGEN 249; /note="H->A: No effect on receptor function."; /evidence="ECO:0000269|PubMed:15141213"; MUTAGEN 252; /note="R->A: Abolishes activation by succinate."; /evidence="ECO:0000269|PubMed:15141213"; MUTAGEN 255; /note="R->A: No effect on receptor function."; /evidence="ECO:0000269|PubMed:15141213"; MUTAGEN 281; /note="R->A: Abolishes activation by succinate."; /evidence="ECO:0000269|PubMed:15141213
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11273702
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15141213
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
18820681
uniprot
proteins
pubmed
23770096
uniprot
proteins
pubmed
34133934
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15141213}; Multi-pass membrane protein {ECO:0000269|PubMed:15141213}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 60..80; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 138..158; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 231..251; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 282..302; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins