PAQR3
entrez
152559
canonical
uniprot
Q6TCH7
canonical
ensembl
ENSG00000163291
resolver
ensp
ENSP00000344203
resolver
ensp
ENSP00000421981
resolver
ensp
ENSP00000425080
resolver
genesymbol
PAQR3
resolver
hgnc
HGNC:30130
resolver
uniprot
A8K5B7
resolver
uniprot
B3KP59
resolver
uniprot
Q6PIQ1
resolver
uniprot
Q86X05
resolver
uniprot
Q8NCP9
resolver
uniprot_entry
PAQR3_HUMAN
resolver
uniprot_sec
A8K5B7
resolver
uniprot_sec
B3KP59
resolver
uniprot_sec
Q6PIQ1
resolver
uniprot_sec
Q86X05
resolver
uniprot_sec
Q8NCP9
resolver
amino_acid_sequence
MHQKLLKSAHYIELGSYQYWPVLVPRGIRLYTYEQIPGSLKDNPYITDGYRAYLPSRLCIKSLFILSNETVNIWSHLLGFFLFFTLGIYDMTSVLPSASASREDFVICSICLFCFQVCMLCSVGYHLFSCHRSEKTCRRWMALDYAGISIGILGCYVSGVFYAFYCNNYWRQVYLITVLAMILAVFFAQIHPNYLTQQWQRLRSIIFCSVSGYGVIPTLHWVWLNGGIGAPIVQDFAPRVIVMYMIALLAFLFYISKVPERYFPGQLNYLGSSHQIWHILAVVMLYWWHQSTVYVMQYRHSKPCPDYVSHL
uniprot
proteins
function
FUNCTION: Golgi-scaffold protein which modulates its interactors activities by anchoring them to the Golgi apparatus (PubMed:18547165, PubMed:26311497). Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi apparatus (PubMed:18547165). Acts as a positive regulator of cholesterol biosynthesis by mediating the anchoring of the SCAP:SREBP complex in the Golgi apparatus, thereby promoting SCAP:SREBF2 complex formation, potentiating SREBF2 and SREBF1 processing and enhancing lipid synthesis (PubMed:26311497). Also regulates PPARA and PPARG functions by mediating their interaction with E3 ubiquitin ligases, such as STUB1 or HUWE1, leading to their polyubiquitination and proteasome-mediated degradation (By similarity). {ECO:0000250|UniProtKB:Q6TCG8, ECO:0000269|PubMed:18547165, ECO:0000269|PubMed:26311497}.
uniprot
proteins
mass_dalton
36217
uniprot
proteins
protein_family
ADIPOR family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16044242
uniprot
proteins
pubmed
18547165
uniprot
proteins
pubmed
26311497
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:18547165, ECO:0000269|PubMed:26311497}; Multi-pass membrane protein {ECO:0000269|PubMed:18547165}.
uniprot
proteins
transmembrane_region
TRANSMEM 74..96; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 106..128; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 141..163; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..195; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 202..224; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 239..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 276..298; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins