Aldh1l1
entrez
64392
canonical
uniprot
P28037
canonical
ensembl
ENSRNOG00000047023
resolver
ensp
ENSRNOP00000065882
resolver
enst
ENSRNOT00000075042
resolver
genesymbol
Aldh1l1
resolver
genesymbol_syn
Fthfd
resolver
uniprot
Q5HZB2
resolver
uniprot_entry
AL1L1_RAT
resolver
uniprot_sec
Q5HZB2
resolver
amino_acid_sequence
MKIAVIGQSLFGQEVYCQLRKEGHEVVGVFTIPDKDGKADPLGLEAEKDGVPVFKFPRWRARGQALPEVVAKYQALGAELNVLPFCSQFIPMEVINAPRHGSIIYHPSLLPRHRGASAINWTLIHGDKKGGFTIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAVRLIAEGTAPRCPQSEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEACGQKLTFFNSTLNTSGLSTQGEALPIPGAHRPGVVTKAGLILFGNDDRMLLVKNIQLEDGKMMPASQFFKGSASSDLELTEAELATAEAVRSSWMRILPNVPEVEDSTDFFKSGAASVDVVRLVEEVKELCDGLELENEDVYMATTFRGFIQLLVRKLRGEDDESECVINYVEKAVNKLTLQMPYQLFIGGEFVDAEGSKTYNTINPTDGSVICQVSLAQVSDVDKAVAAAKEAFENGLWGKINARDRGRLLYRLADVMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGATIPINQARPNRNLTLTKKEPVGVCGIVIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNILPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCALSNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEESIHNQFVQKVVEEVEKMKIGNPLERDTNHGPQNHEAHLRKLVEYCQRGVKEGATLVCGGNQVPRPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFADGDVDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFINTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRIKTVTFEY
uniprot
proteins
ec_number
1.5.1.6
uniprot
proteins
function
FUNCTION: Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:10585460, PubMed:17302434, PubMed:17884809, PubMed:1848231, PubMed:7822273). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (PubMed:1848231). {ECO:0000269|PubMed:10585460, ECO:0000269|PubMed:17302434, ECO:0000269|PubMed:17884809, ECO:0000269|PubMed:1848231, ECO:0000269|PubMed:7822273}.
uniprot
proteins
mass_dalton
98874
uniprot
proteins
mutagenesis
MUTAGEN 142; /note="D->A: Loss of formyltetrahydrofolate dehydrogenase activity. Loss of formyltetrahydrofolate hydrolase activity. No effect on aldehyde dehydrogenase activity."; /evidence="ECO:0000269|PubMed:10585460"; MUTAGEN 354; /note="S->A: Loss of phosphopantetheinylation. Loss of formyltetrahydrofolate dehydrogenase activity. No effect on hydrolase and aldehyde dehydrogenase activities in vitro."; /evidence="ECO:0000269|PubMed:17884809"; MUTAGEN 673; /note="E->A: Loss of aldehyde dehydrogenase activity."; /evidence="ECO:0000269|PubMed:17302434"; MUTAGEN 707; /note="C->A: Loss of formyltetrahydrofolate dehydrogenase activity. No effect on formyltetrahydrofolate hydrolase activity. No effect on NADP binding. No effect on homotetramerization."; /evidence="ECO:0000269|PubMed:7822273
uniprot
proteins
post_translational_modification
PTM: Phosphopantetheinylation at Ser-354 by AASDHPPT is required for the formyltetrahydrofolate dehydrogenase activity. {ECO:0000269|PubMed:17884809}.
uniprot
proteins
protein_family
ALDH1L subfamily
uniprot
proteins
protein_family
GART family; Aldehyde dehydrogenase family
uniprot
proteins
pubmed
10585460
uniprot
proteins
pubmed
14729668
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16396499
uniprot
proteins
pubmed
17302434
uniprot
proteins
pubmed
17884809
uniprot
proteins
pubmed
1848231
uniprot
proteins
pubmed
21540484
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
3392008
uniprot
proteins
pubmed
7822273
uniprot
proteins
sequence_length
902
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:1848231, ECO:0000269|PubMed:3392008}.
uniprot
proteins