Gramd1a
entrez
52857
canonical
uniprot
Q8VEF1
canonical
ensembl
ENSMUSG00000001248
resolver
ensp
ENSMUSP00000001280
resolver
genesymbol
Gramd1a
resolver
genesymbol_syn
D7Bwg0611e
resolver
genesymbol_syn
Kiaa1533
resolver
uniprot
Q3U914
resolver
uniprot
Q3UD89
resolver
uniprot
Q69ZH2
resolver
uniprot
Q8BNF1
resolver
uniprot_entry
ASTRA_MOUSE
resolver
uniprot_sec
Q3U914
resolver
uniprot_sec
Q3UD89
resolver
uniprot_sec
Q69ZH2
resolver
uniprot_sec
Q8BNF1
resolver
amino_acid_sequence
MFDTTPHSGRSSPSSSPSLRKRLQLLPPIRPPPASEPEPGTMVEKGSDSSSEKSGVSGTLSTQSLGSRNFIRNSKKMQSWYSMLCPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVCPLQLNGLGSPKEVGDVIALSDISPSGAADHSQEPSPVGSRRGRVTPNLSRASSDADHGAEEDKEEQTDGLDASSSQTVTPVAEPLSSEPTPPDGPTSSLGPLDLLSREELLTDTSNSSSSTGEEGDLAALLPDLSGRLLINSVFHMGAERLQQMLFSDSPFLQGFLQQRKFTDVTLSPWSSDSKCHQRRVLTYTIPISNQLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYCILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLDRELAKAEKLSLEEGGKDTRGLLSGLRRRKRPLSWRGHRDGPQHPDPDPCTQTSMHTSGSLSSRFSEPSVDQGPGAGIPSALVLISIVLIVLIALNALLFYRLWSLERTAHTFESWHSLALAKGKFPQTATEWAEILALQKHFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVPDPPLDTQPQPDDSFP
uniprot
proteins
function
FUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (PubMed:30220461). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (PubMed:30220461). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (PubMed:30220461). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (PubMed:30220461). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (PubMed:30220461). May play a role in tumor progression (PubMed:27585821). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome. This function in autophagy requires its cholesterol-transfer activity (By similarity). {ECO:0000250|UniProtKB:Q96CP6, ECO:0000269|PubMed:27585821, ECO:0000269|PubMed:30220461}.
uniprot
proteins
mass_dalton
80699
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27585821
uniprot
proteins
pubmed
30220461
uniprot
proteins
sequence_length
722
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30220461}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30220461}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q96CP6}. Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:30220461). Localizes to distinct EPCS than GRAMD2A and ESYT2/3 (By similarity). {ECO:0000250|UniProtKB:Q96CP6, ECO:0000269|PubMed:30220461}.
uniprot
proteins
transmembrane_region
TRANSMEM 609..629; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins