Ntrk1
entrez
59109
canonical
uniprot
P35739
canonical
ensembl
ENSRNOG00000013953
resolver
ensembl
ENSRNOG00055023126
resolver
ensembl
ENSRNOG00060031729
resolver
ensembl
ENSRNOG00065029663
resolver
ensp
ENSRNOP00000018961
resolver
ensp
ENSRNOP00000085208
resolver
genesymbol
Ntrk1
resolver
genesymbol_syn
Trk
resolver
genesymbol_syn
Trka
resolver
uniprot_entry
NTRK1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: The pro-survival signaling effect of NTRK1 in neurons requires its endocytosis into signaling early endosomes and its retrograde axonal transport. This is regulated by different proteins including CFL1, RAC1 and SORT1. NTF3 is unable to induce this signaling probably due to the lability of the NTF3-NTRK1 complex in endosomes (By similarity). SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. Regulated by NGFR (By similarity). {ECO:0000250|UniProtKB:Q3UFB7}.
uniprot
proteins
amino_acid_sequence
MLRGQRHGQLGWHRPAAGLGGLVTSLMLACACAASCRETCCPVGPSGLRCTRAGTLNTLRGLRGAGNLTELYVENQRDLQRLEFEDLQGLGELRSLTIVKSGLRFVAPDAFHFTPRLSHLNLSSNALESLSWKTVQGLSLQDLTLSGNPLHCSCALLWLQRWEQEDLCGVYTQKLQGSGSGDQFLPLGHNNSCGVPSVKIQMPNDSVEVGDDVFLQCQVEGQALQQADWILTELEGTATMKKSGDLPSLGLTLVNVTSDLNKKNVTCWAENDVGRAEVSVQVSVSFPASVHLGKAVEQHHWCIPFSVDGQPAPSLRWFFNGSVLNETSFIFTQFLESALTNETMRHGCLRLNQPTHVNNGNYTLLAANPYGQAAASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSRDPVEKKDETPFGVSVAVGLAVSAALFLSALLLVLNKCGQRSKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIMENPQYFSDTCVHHIKRQDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGRELERPRACPPDVYAIMRGCWQREPQQRLSMKDVHARLQALAQAPPSYLDVLG
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1312719, PubMed:1850821, PubMed:31440771). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. {ECO:0000250|UniProtKB:P04629, ECO:0000250|UniProtKB:Q3UFB7, ECO:0000269|PubMed:1312719, ECO:0000269|PubMed:1850821, ECO:0000269|PubMed:20811452}.
uniprot
proteins
mass_dalton
87868
uniprot
proteins
mutagenesis
MUTAGEN 527; /note="V->D: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:9856458
uniprot
proteins
post_translational_modification
PTM: Ligand-mediated autophosphorylation. Interaction with SQSTM1 is phosphotyrosine-dependent. Autophosphorylation at Tyr-499 mediates interaction and phosphorylation of SHC1.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:P04629}.; PTM: Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination by NEDD4L leads to degradation (By similarity). Ubiquitination regulates the internalization of the receptor (By similarity). {ECO:0000250|UniProtKB:P04629, ECO:0000250|UniProtKB:Q3UFB7}.
uniprot
proteins
protein_family
Insulin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
11150334
uniprot
proteins
pubmed
11244088
uniprot
proteins
pubmed
12471037
uniprot
proteins
pubmed
1312719
uniprot
proteins
pubmed
15167895
uniprot
proteins
pubmed
15378608
uniprot
proteins
pubmed
16223723
uniprot
proteins
pubmed
16306406
uniprot
proteins
pubmed
17724123
uniprot
proteins
pubmed
17967490
uniprot
proteins
pubmed
1850821
uniprot
proteins
pubmed
18624909
uniprot
proteins
pubmed
20811452
uniprot
proteins
pubmed
26446845
uniprot
proteins
pubmed
31440771
uniprot
proteins
pubmed
8155326
uniprot
proteins
pubmed
8325889
uniprot
proteins
pubmed
9856458
uniprot
proteins
sequence_length
799
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1312719, ECO:0000269|PubMed:16306406, ECO:0000269|PubMed:1850821, ECO:0000269|PubMed:26446845, ECO:0000269|PubMed:31440771}; Single-pass type I membrane protein {ECO:0000305|PubMed:1850821}. Early endosome membrane {ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:26446845}; Single-pass type I membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:26446845}; Single-pass type I membrane protein {ECO:0000305}. Recycling endosome membrane {ECO:0000269|PubMed:26446845}; Single-pass type I membrane protein {ECO:0000305}. Note=Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation (PubMed:17724123, PubMed:26446845). Recruited to late endosomes after NGF stimulation (PubMed:17724123, PubMed:26446845). Colocalized with RAPGEF2 at late endosomes (PubMed:17724123). {ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:26446845}.
uniprot
proteins
transmembrane_region
TRANSMEM 419..442; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins