Dsg4
entrez
291754
canonical
uniprot
Q6W3B0
canonical
ensembl
ENSRNOG00000022364
resolver
ensembl
ENSRNOG00055018274
resolver
ensembl
ENSRNOG00060012521
resolver
ensembl
ENSRNOG00065015554
resolver
ensp
ENSRNOP00000105283
resolver
ensp
ENSRNOP00055024978
resolver
ensp
ENSRNOP00060016732
resolver
ensp
ENSRNOP00065020323
resolver
enst
ENSRNOT00000038450
resolver
enst
ENSRNOT00055030994
resolver
enst
ENSRNOT00060021221
resolver
enst
ENSRNOT00065025837
resolver
genesymbol
Dsg4
resolver
uniprot_entry
DSG4_RAT
resolver
amino_acid_sequence
MDWLLFRNICLLILFMVVLGVNSEFIVEVKELDIENGTTTWQTVRRQKREWIKFAAACREGEDNSKRNPIARIRSDCEVSQRITYRISGAGIDRPPYGVFTINPRTGEINITSVVDREITPLFLIHCRALNSRGEDLERPLELRVKVMDVNDNPPVFTQNVYTANIEENSDANALVVKLSATDADEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSNFLDREQHSMYNLLVRGSDRDGATDGLSSECDCRIKILDVNDNFPILEKTSYSASIEENCLSSELIRLQAIDLDEEGTDNWLAQYSILSGNDGNWFEIQTDPKTNEGILKLVKMLDYEQEPNIYLSIGVRNQAEFHHSVASQFQMHSTPVRIQVINVREGPTFRPSSMTFSLRGGMRGDSLMNYVLGTYTAIDMDTGSPATNVRYVIGHDAGSWLKVDSRTGEIQFSREFDTKSKYITDGMYAAEILAIDDGSGRTATGTICIEVPDANDYCPVIYAESRSVCTHASSVRIYVNDHSFGAPFTFCVVDESPDTADIWDIRSINGTSAILMTEQTLSPGPYQIPILVKDSHNRACELPQTVLLDACLCDDYHVCLHSSTTGIYTGDTIWVTDDMGTVTDDGLRQSNVGLGPAGIGMIILGLLLLFLSPLLLLMCCCKRRQPEGLGTRFAPVPEGGEGVMQPWRIEGAHPEDRDVSNICVPMTASNTQDRIDSSEIYTNTYAGGGTVEGGVSGVELNTGVGTAAGIAAGGATGTLRKRSSTIGTLREYQDTGMNMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGTGSPVGSIGCCSWIVDDLDESYMETLDPKFRTLAEICLDTEIEPFPSHQACIPISTDLPLLGPNYFVNESSGMTLSEAEFQAEMAAASEPMIHGDIIVTETYTATDPCVQPTTIVFDSQLPPNVVVTETVMAPVYDVQGNICVPAEIANTHNVYYAERVVASPGVPDMGNGNIGDTCIGPVMSGGILVGPEIQVTQMMSPDIHISQTTRSTSPMTSQHRVTRYSNIHYSRQ
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Dsg4 are the cause of an autosomal recessive phenotype lanceolate hair (lah) (PubMed:15081105). Lah rat pups develop only a few short hairs on the head and neck which form a lance head at the tip and disappear within one month (PubMed:15081105). Hair regrows again a few days later, following a 29-day cycle of external growth and loss (PubMed:15081105). Almost complete pelage hair loss occurs by 18 month (PubMed:15081105). {ECO:0000269|PubMed:15081105}.
uniprot
proteins
function
FUNCTION: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). Plays a role in moderating lymphocyte migration to inflamed skin and maintaining homeostasis of the epidermal inflammatory response (PubMed:33995349). {ECO:0000250|UniProtKB:Q7TMD7, ECO:0000269|PubMed:33995349}.
uniprot
proteins
mass_dalton
114367
uniprot
proteins
pubmed
15081105
uniprot
proteins
pubmed
33995349
uniprot
proteins
sequence_length
1040
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86SJ6}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, desmosome {ECO:0000250|UniProtKB:Q86SJ6}. Note=Colocalizes with JUP at desmosomes. {ECO:0000250|UniProtKB:Q86SJ6}.
uniprot
proteins
transmembrane_region
TRANSMEM 634..654; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins