Lta4h
entrez
16993
canonical
uniprot
P24527
canonical
ensembl
ENSMUSG00000015889
resolver
ensp
ENSMUSP00000016033
resolver
ensp
ENSMUSP00000309692
resolver
enst
ENSMUST00000016033
resolver
genesymbol
Lta4h
resolver
uniprot
Q3UY71
resolver
uniprot
Q8VDR8
resolver
uniprot_entry
LKHA4_MOUSE
resolver
uniprot_sec
Q3UY71
resolver
uniprot_sec
Q8VDR8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by bestatin (By similarity). The epoxide hydrolase activity is restrained by suicide inactivation that involves binding of LTA4 to Tyr-379 (PubMed:9287304). 4-(4-benzylphenyl)thiazol-2-amine (ARM1) selectively inhibits the epoxide hydrolase activity (By similarity). {ECO:0000250|UniProtKB:P09960, ECO:0000269|PubMed:9287304}.
uniprot
proteins
amino_acid_sequence
MPEVADTCSLASPASVCRTQHLHLRCSVDFARRTLTGTAALTVQSQEENLRSLTLDTKDLTIEKVVINGQEVKYTLGESQGYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSANEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGESHPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSVTTDDWKSFLYSHFKDKVDLLNQVDWNTWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAKEEDLSSFSIADLKDLSSHQLNEFLAQVLQKAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVHTYQEHKASMHPVTAMLVGRDLKVD
uniprot
proteins
ec_number
3.3.2.6
uniprot
proteins
ec_number
3.4.11.4
uniprot
proteins
function
FUNCTION: Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities (By similarity). Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4), as well as other lipid epoxides (PubMed:1881903, PubMed:9287304). Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (By similarity). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (By similarity). {ECO:0000250|UniProtKB:P09960, ECO:0000269|PubMed:1881903, ECO:0000269|PubMed:20813919, ECO:0000269|PubMed:9287304}.
uniprot
proteins
mass_dalton
69051
uniprot
proteins
mutagenesis
MUTAGEN 296; /note="H->Y: Complete loss of LTA4 hydrolase and peptidase enzyme activities."; /evidence="ECO:0000269|PubMed:1881903"; MUTAGEN 300; /note="H->Y: Complete loss of LTA4 hydrolase and peptidase enzyme activities."; /evidence="ECO:0000269|PubMed:1881903"; MUTAGEN 319; /note="E->Q: Complete loss of LTA4 hydrolase and peptidase enzyme activities."; /evidence="ECO:0000269|PubMed:1881903"; MUTAGEN 384; /note="Y->F,H,Q: Alters leukotriene hydrolase activity, strongly enhancing the formation of a metabolite that is normally produced in trace amounts."; /evidence="ECO:0000269|PubMed:9287304
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; leukotriene B4 biosynthesis. {ECO:0000269|PubMed:1881903, ECO:0000269|PubMed:9287304}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-416 inhibits leukotriene-A4 hydrolase activity. {ECO:0000250|UniProtKB:P09960}.
uniprot
proteins
protein_family
Peptidase M1 family
uniprot
proteins
pubmed
10586081
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1710117
uniprot
proteins
pubmed
1881903
uniprot
proteins
pubmed
20813919
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9287304
uniprot
proteins
sequence_length
611
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P09960}.
uniprot
proteins