ACBD3
entrez
64746
canonical
uniprot
Q9H3P7
canonical
ensembl
ENSG00000182827
resolver
ensp
ENSP00000355777
resolver
enst
ENST00000366812
resolver
genesymbol
ACBD3
resolver
genesymbol_syn
GCP60
resolver
genesymbol_syn
GOCAP1
resolver
genesymbol_syn
GOLPH1
resolver
hgnc
HGNC:15453
resolver
uniprot
B2RB29
resolver
uniprot
Q5VTJ0
resolver
uniprot
Q6P9F1
resolver
uniprot
Q8IZC5
resolver
uniprot
Q8N4D6
resolver
uniprot
Q9H6U3
resolver
uniprot_entry
GCP60_HUMAN
resolver
uniprot_sec
B2RB29
resolver
uniprot_sec
Q5VTJ0
resolver
uniprot_sec
Q6P9F1
resolver
uniprot_sec
Q8IZC5
resolver
uniprot_sec
Q8N4D6
resolver
uniprot_sec
Q9H6U3
resolver
amino_acid_sequence
MAAVLNAERLEVSVDGLTLSPDPEERPGAEGAPLLPPPLPPPSPPGSGRGPGASGEQPEPGEAAAGGAAEEARRLEQRWGFGLEELYGLALRFFKEKDGKAFHPTYEEKLKLVALHKQVLMGPYNPDTCPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNRCCHLFSTYVASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSVNGQAKTHTDSSEKELEPEAAEEALENGPKESLPVIAAPSMWTRPQIKDFKEKIQQDADSVITVGRGEVVTVRVPTHEEGSYLFWEFATDNYDIGFGVYFEWTDSPNTAVSVHVSESSDDDEEEEENIGCEEKAKKNANKPLLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYTR
uniprot
proteins
function
FUNCTION: Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). {ECO:0000250|UniProtKB:Q8BMP6, ECO:0000269|PubMed:11590181, ECO:0000269|PubMed:27009356}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites. {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}.
uniprot
proteins
mass_dalton
60593
uniprot
proteins
mutagenesis
MUTAGEN 243; /note="K->A: No effect on PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 244; /note="Q->A: No effect on PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 245; /note="Q->A: No effect on PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 246; /note="I->A: Partial loss of PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 253; /note="Q->A: No effect on PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 254; /note="T->A: No effect on PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 256..258; /note="VQF->AAA: Loss of PI4KB-, TBC1D22A- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 257; /note="Q->A: Partial loss of PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 258..259; /note="FQ->AA: Complete loss of interaction with PI4KB."; /evidence="ECO:0000269|PubMed:27989622"; MUTAGEN 258..259; /note="FQ->AA: Loss of interaction with PI4KB."; /evidence="ECO:0000269|PubMed:27989622"; MUTAGEN 258; /note="F->A: Differential effect on PI4KB- and TBC1D22B-binding, with PI4KB-binding being much more affected than TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552, ECO:0000269|PubMed:27009356"; MUTAGEN 259; /note="Q->A: No effect on PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 260; /note="Q->A: No effect on PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 261; /note="Y->A: No effect on PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 264..266; /note="QQY->AAA: No effect on PI4KB-, TBC1D22A- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 266; /note="Y->A: No loss of interaction with PI4KB."; /evidence="ECO:0000269|PubMed:27009356"; MUTAGEN 267..269; /note="PGN->AAA: Loss of PI4KB-, TBC1D22A- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 275; /note="I->A: No effect on PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 276; /note="L->A: No effect on PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 282..285; /note="EQHY->AAAA: Loss of PI4KB-, TBC1D22A- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 284; /note="H->A: Almost complete loss of PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552, ECO:0000269|PubMed:27009356"; MUTAGEN 285; /note="Y->A: Differential loss of PI4KB- and TBC1D22B-binding, with PI4KB-binding being much more affected than TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552, ECO:0000269|PubMed:27009356"; MUTAGEN 286; /note="Q->A: No effect on PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 287; /note="Q->A: No effect on PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 288; /note="Y->A: Almost complete loss of PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552, ECO:0000269|PubMed:27009356"; MUTAGEN 344..345; /note="SS->AA: No effect on PI4KB-, TBC1D22A- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 375..377; /note="WTR->ATA: 80% reduced ability to interact with the 3A protein of enterovirus D68."; /evidence="ECO:0000269|PubMed:31381608"; MUTAGEN 380..381; /note="IK->AE: No effect on interaction with PI4KB but loss of interaction with Kobuviral (Aichi) 3A protein. Loss of ability to sensitize PI4KB activation by Kobuviral (Aichi) 3A protein."; /evidence="ECO:0000269|PubMed:27989622"; MUTAGEN 403..407; /note="VTVRV->AAAAA: 95% reduced ability to interact with the 3A protein of enterovirus D68."; /evidence="ECO:0000269|PubMed:31381608"; MUTAGEN 414..417; /note="SYLF->AAAA: 60% reduced ability to interact with the 3A protein of enterovirus D68."; /evidence="ECO:0000269|PubMed:31381608"; MUTAGEN 414..416; /note="SYL->AAA: No effect on PI4KB-, TBC1D22A- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 417..420; /note="FWEF->AAAA: No effect on PI4KB-, TBC1D22A- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 433..435; /note="FEW->AAA: No effect on PI4KB-, TBC1D22A- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 494..496; /note="GSH->AAA: No effect on PI4KB-, TBC1D22A- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 511..513; /note="SYS->AAA: No effect on PI4KB-, TBC1D22A- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 511; /note="S->A: Partial loss of PI4KB- and TBC1D22B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 514..516; /note="LWR->AAA: Almost complete loss of Golgi loalization."; /evidence="ECO:0000269|PubMed:31381608"; MUTAGEN 523..527; /note="RVYYT->AAAAA: 75% reduced ability to interact with the 3A protein of enterovirus D68."; /evidence="ECO:0000269|PubMed:31381608"; MUTAGEN 525; /note="Y->A: No effect on interaction with PI4KB but loss of interaction with Kobuviral (Aichi) 3A protein. Loss of ability to sensitize PI4KB activation by Kobuviral (Aichi) 3A protein."; /evidence="ECO:0000269|PubMed:27989622
uniprot
proteins
pubmed
11590181
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22124328
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22258260
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23572552
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27009356
uniprot
proteins
pubmed
27989622
uniprot
proteins
pubmed
28065508
uniprot
proteins
pubmed
30755512
uniprot
proteins
pubmed
31381608
uniprot
proteins
sequence_length
528
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:27009356, ECO:0000269|PubMed:30755512, ECO:0000269|PubMed:31381608}; Peripheral membrane protein {ECO:0000305|PubMed:31381608}; Cytoplasmic side {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Also mitochondrial (via its interaction with PBR). {ECO:0000250}.
uniprot
proteins