Krt8
entrez
16691
canonical
uniprot
P11679
canonical
ensembl
ENSMUSG00000049382
resolver
ensp
ENSMUSP00000023952
resolver
enst
ENSMUST00000023952
resolver
genesymbol
Krt8
resolver
genesymbol_syn
Krt2-8
resolver
uniprot
Q3KQK5
resolver
uniprot
Q3TGI1
resolver
uniprot
Q3TJE1
resolver
uniprot
Q3TKY7
resolver
uniprot
Q61463
resolver
uniprot
Q61518
resolver
uniprot
Q61519
resolver
uniprot_entry
K2C8_MOUSE
resolver
uniprot_sec
Q3KQK5
resolver
uniprot_sec
Q3TGI1
resolver
uniprot_sec
Q3TJE1
resolver
uniprot_sec
Q3TKY7
resolver
uniprot_sec
Q61463
resolver
uniprot_sec
Q61518
resolver
uniprot_sec
Q61519
resolver
amino_acid_sequence
MSIRVTQKSYKMSTSGPRAFSSRSFTSGPGARISSSSFSRVGSSSSSFRGSMGTGVGLGGFGGAGVGGITAVTVNQSLLSPLKLEVDPNIQAVRTQEKEQIKSLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTSRSNMDNMFESYINNLRRQLEALGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQIHEEEIRELQSQISDTSVVLSMDNSRSLDMDGIIAEVRAQYEDIANRSRAEAETMYQIKYEELQTLAGKHGDDLRRTKTEISEMNRNINRLQAEIEALKGQRASLEAAIADAEQRGEMAIKDAQTKLAELEAALQRAKQDMARQLREYQELMNVKLALDIEITTYRKLLEGEESRLESGMQNMSIHTKTTSGYSGGLSSSYGGLTSPGFSYGMSSFQPGFGSAGGSNTFSRTTKAVVVKKIETRDGKLVSESSDVVSK
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in simple epithelial cells. Together with its obligate type I partner KRT18, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to epithelial cells (PubMed:11514590). Also involved in maintaining epithelial integrity and protecting cells from non-mechanical stress, such as apoptosis (PubMed:11514590). Also required for ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement (By similarity). In striated muscle, together with KRT19, may contribute to linking the contractile apparatus to dystrophin at the costameres (By similarity). {ECO:0000250|UniProtKB:P05787, ECO:0000269|PubMed:11514590}.
uniprot
proteins
mass_dalton
54565
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-80 phosphorylation plays an important role in keratin filament reorganization (By similarity). {ECO:0000250}.; PTM: O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation (By similarity). {ECO:0000250}.; PTM: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. {ECO:0000250}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
11514590
uniprot
proteins
pubmed
12857878
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1717348
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
20724476
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2454862
uniprot
proteins
pubmed
2464527
uniprot
proteins
pubmed
2467842
uniprot
proteins
pubmed
24940650
uniprot
proteins
pubmed
25617501
uniprot
proteins
pubmed
9864371
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9864371}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q10758}. Nucleus matrix {ECO:0000250|UniProtKB:Q10758}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P05787}.
uniprot
proteins