LDHB
entrez
3945
canonical
uniprot
P07195
canonical
ensembl
ENSG00000111716
resolver
ensp
ENSP00000229319
resolver
ensp
ENSP00000379386
resolver
ensp
ENSP00000500484
resolver
ensp
ENSP00000565224
resolver
ensp
ENSP00000565225
resolver
ensp
ENSP00000565226
resolver
ensp
ENSP00000565227
resolver
ensp
ENSP00000565228
resolver
ensp
ENSP00000565229
resolver
ensp
ENSP00000565230
resolver
ensp
ENSP00000585393
resolver
ensp
ENSP00000585394
resolver
ensp
ENSP00000585395
resolver
ensp
ENSP00000585396
resolver
ensp
ENSP00000614737
resolver
ensp
ENSP00000614738
resolver
ensp
ENSP00000614739
resolver
ensp
ENSP00000753813
resolver
enst
ENST00000350669
resolver
enst
ENST00000396076
resolver
enst
ENST00000673047
resolver
enst
ENST00000895165
resolver
enst
ENST00000895166
resolver
enst
ENST00000895167
resolver
enst
ENST00000895168
resolver
enst
ENST00000895169
resolver
enst
ENST00000895170
resolver
enst
ENST00000895171
resolver
enst
ENST00000915334
resolver
enst
ENST00000915335
resolver
enst
ENST00000915336
resolver
enst
ENST00000915337
resolver
enst
ENST00000944678
resolver
enst
ENST00000944679
resolver
enst
ENST00000944680
resolver
genesymbol
HEL-S-281
resolver
genesymbol
LDHB
resolver
genesymbol_syn
LDHB
resolver
hgnc
HGNC:6541
resolver
uniprot
A0A5F9ZHM4
resolver
uniprot
Q5U077
resolver
uniprot_entry
A0A5F9ZHM4_HUMAN
resolver
uniprot_entry
LDHB_HUMAN
resolver
uniprot_entry
Q5U077_HUMAN
resolver
amino_acid_sequence
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
uniprot
proteins
disease_involvement
DISEASE: Lactate dehydrogenase B deficiency (LDHBD) [MIM:614128]: A condition with no deleterious effects on health. LDHBD is of interest to laboratory medicine mainly because it can cause misdiagnosis in those disorders in which elevation of serum LDH is expected. {ECO:0000269|PubMed:10211631, ECO:0000269|PubMed:10509905, ECO:0000269|PubMed:11509017, ECO:0000269|PubMed:1587525, ECO:0000269|PubMed:2334429, ECO:0000269|PubMed:8314553, ECO:0000269|PubMed:8462975, ECO:0000269|PubMed:8611651, ECO:0000269|PubMed:9929983, ECO:0000269|Ref.23}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.1.1.27
uniprot
proteins
function
FUNCTION: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}.
uniprot
proteins
mass_dalton
36638
uniprot
proteins
mutagenesis
MUTAGEN 53; /note="D->A: Abolishes interaction with MP31."; /evidence="ECO:0000269|PubMed:33406399"; MUTAGEN 100; /note="R->A: Abolishes interaction with MP31."; /evidence="ECO:0000269|PubMed:33406399
uniprot
proteins
pathway_participation
PATHWAY: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. {ECO:0000305|PubMed:27618187}.
uniprot
proteins
protein_family
LDH family
uniprot
proteins
protein_family
LDH/MDH superfamily
uniprot
proteins
pubmed
10211631
uniprot
proteins
pubmed
10508479
uniprot
proteins
pubmed
10509905
uniprot
proteins
pubmed
11276087
uniprot
proteins
pubmed
11509017
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
1587525
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2334429
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27618187
uniprot
proteins
pubmed
2930497
uniprot
proteins
pubmed
33406399
uniprot
proteins
pubmed
33535099
uniprot
proteins
pubmed
3435492
uniprot
proteins
pubmed
8314553
uniprot
proteins
pubmed
8462975
uniprot
proteins
pubmed
8611651
uniprot
proteins
pubmed
9929983
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion inner membrane {ECO:0000269|PubMed:27618187}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins