SS18
entrez
6760
canonical
uniprot
Q15532
canonical
ensembl
ENSG00000141380
resolver
ensp
ENSP00000269137
resolver
ensp
ENSP00000414516
resolver
ensp
ENSP00000438066
resolver
ensp
ENSP00000625526
resolver
enst
ENST00000542420
resolver
genesymbol
SS18
resolver
genesymbol_syn
SSXT
resolver
genesymbol_syn
SYT
resolver
hgnc
HGNC:11340
resolver
uniprot
B0YJ95
resolver
uniprot
B4DLD3
resolver
uniprot
B4DR34
resolver
uniprot
F6SV23
resolver
uniprot
Q16404
resolver
uniprot
Q4VAX0
resolver
uniprot
Q4VAX1
resolver
uniprot
Q9BXC6
resolver
uniprot_entry
B4DLD3_HUMAN
resolver
uniprot_entry
B4DR34_HUMAN
resolver
uniprot_entry
F6SV23_HUMAN
resolver
uniprot_entry
Q4VAX0_HUMAN
resolver
uniprot_entry
SSXT_HUMAN
resolver
uniprot_sec
B0YJ95
resolver
uniprot_sec
Q16404
resolver
uniprot_sec
Q4VAX1
resolver
uniprot_sec
Q9BXC6
resolver
amino_acid_sequence
MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQGQYGNYQQ
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency). {ECO:0000269|PubMed:7495284, ECO:0000269|PubMed:7539744}.
uniprot
proteins
function
FUNCTION: Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). {ECO:0000269|PubMed:15919756, ECO:0000269|PubMed:29374058}.
uniprot
proteins
mass_dalton
45929
uniprot
proteins
protein_family
SS18 family
uniprot
proteins
pubmed
11368913
uniprot
proteins
pubmed
11423977
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15919756
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
29374058
uniprot
proteins
pubmed
7495284
uniprot
proteins
pubmed
7539744
uniprot
proteins
pubmed
7951320
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins