Rgs2
entrez
19735
canonical
uniprot
O08849
canonical
ensembl
ENSMUSG00000026360
resolver
ensp
ENSMUSP00000115558
resolver
enst
ENSMUST00000127206
resolver
genesymbol
Rgs2
resolver
uniprot
Q544S7
resolver
uniprot
Q91WX1
resolver
uniprot
Q9JL24
resolver
uniprot_entry
RGS2_MOUSE
resolver
uniprot_sec
Q544S7
resolver
uniprot_sec
Q91WX1
resolver
uniprot_sec
Q9JL24
resolver
amino_acid_sequence
MQSAMFLAVQHDCVPMDKSAGNGPKVEEKREKMKRTLLKDWKTRLSYFLQNSSAPGKPKTGKKSKQQTFIKPSPEEAQLWAEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKSLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT
uniprot
proteins
function
FUNCTION: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (PubMed:14608379). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity). {ECO:0000250|UniProtKB:P41220, ECO:0000269|PubMed:14608379}.
uniprot
proteins
mass_dalton
24294
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity. Phosphorylation of Ser-3 protects RGS2 from FBXO44-mediated proteasomal degradation. {ECO:0000250|UniProtKB:P41220}.; PTM: Ubiquitinated by the cullin-RING ligase (CRL) complex composed of CUL4B, DDB1 and FBXO44; ubiquitination leads to RGS2 proteasomal degradation. {ECO:0000250|UniProtKB:P41220}.
uniprot
proteins
pubmed
10779778
uniprot
proteins
pubmed
14608379
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9079700
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P41220}. Cytoplasm {ECO:0000250|UniProtKB:P41220}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P41220}.
uniprot
proteins