NEMP1
entrez
23306
canonical
uniprot
O14524
canonical
ensembl
ENSG00000166881
resolver
ensp
ENSP00000300128
resolver
ensp
ENSP00000368701
resolver
genesymbol
NEMP1
resolver
genesymbol_syn
KIAA0286
resolver
genesymbol_syn
TMEM194
resolver
genesymbol_syn
TMEM194A
resolver
hgnc
HGNC:29001
resolver
uniprot
Q17R72
resolver
uniprot
Q68DH0
resolver
uniprot
Q6IQ25
resolver
uniprot_entry
NEMP1_HUMAN
resolver
uniprot_sec
Q17R72
resolver
uniprot_sec
Q68DH0
resolver
uniprot_sec
Q6IQ25
resolver
amino_acid_sequence
MAGGMKVAVSPAVGPGPWGSGVGGGGTVRLLLILSGCLVYGTAETDVNVVMLQESQVCEKRASQQFCYTNVLIPKWHDIWTRIQIRVNSSRLVRVTQVENEEKLKELEQFSIWNFFSSFLKEKLNDTYVNVGLYSTKTCLKVEIIEKDTKYSVIVIRRFDPKLFLVFLLGLMLFFCGDLLSRSQIFYYSTGMTVGIVASLLIIIFILSKFMPKKSPIYVILVGGWSFSLYLIQLVFKNLQEIWRCYWQYLLSYVLTVGFMSFAVCYKYGPLENERSINLLTWTLQLMGLCFMYSGIQIPHIALAIIIIALCTKNLEHPIQWLYITCRKVCKGAEKPVPPRLLTEEEYRIQGEVETRKALEELREFCNSPDCSAWKTVSRIQSPKRFADFVEGSSHLTPNEVSVHEQEYGLGSIIAQDEIYEEASSEEEDSYSRCPAITQNNFLT
uniprot
proteins
function
FUNCTION: Together with EMD, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). Required for female fertility (By similarity). Essential for normal erythropoiesis (By similarity). Required for efficient nuclear envelope opening and enucleation during the late stages of erythroblast maturation (By similarity). {ECO:0000250|UniProtKB:Q6ZQE4, ECO:0000269|PubMed:32923640}.
uniprot
proteins
mass_dalton
50640
uniprot
proteins
post_translational_modification
PTM: Phosphorylation may regulate its interaction with RAN-GTP. {ECO:0000250|UniProtKB:Q6ZQE4}.
uniprot
proteins
protein_family
NEMP family
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
32923640
uniprot
proteins
pubmed
9179496
uniprot
proteins
sequence_length
444
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250|UniProtKB:Q6ZQE4}; Multi-pass membrane protein {ECO:0000255}; Nucleoplasmic side {ECO:0000250|UniProtKB:B9X187}. Nucleus envelope {ECO:0000250|UniProtKB:Q6ZQE4}. Note=Colocalizes with lamins and RAN-GTP at the nuclear envelope. {ECO:0000250|UniProtKB:Q6ZQE4}.
uniprot
proteins
transmembrane_region
TRANSMEM 161..181; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 216..236; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 245..265; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins