Senp7
entrez
66315
canonical
uniprot
Q8BUH8
canonical
ensembl
ENSMUSG00000052917
resolver
ensp
ENSMUSP00000043023
resolver
ensp
ENSMUSP00000086776
resolver
ensp
ENSMUSP00000086779
resolver
ensp
ENSMUSP00000144116
resolver
ensp
ENSMUSP00000156009
resolver
ensp
ENSMUSP00000228379
resolver
ensp
ENSMUSP00000228381
resolver
ensp
ENSMUSP00000228382
resolver
ensp
ENSMUSP00000228383
resolver
ensp
ENSMUSP00000228384
resolver
ensp
ENSMUSP00000228385
resolver
ensp
ENSMUSP00000228386
resolver
ensp
ENSMUSP00000228392
resolver
ensp
ENSMUSP00000356263
resolver
enst
ENSMUST00000049128
resolver
enst
ENSMUST00000089360
resolver
enst
ENSMUST00000089362
resolver
enst
ENSMUST00000201011
resolver
enst
ENSMUST00000202000
resolver
genesymbol
Senp7
resolver
genesymbol_syn
Kiaa1707
resolver
genesymbol_syn
Susp2
resolver
uniprot
A0A0J9YUC9
resolver
uniprot
A0A338P6K5
resolver
uniprot
E9Q1L5
resolver
uniprot
F7DCK9
resolver
uniprot
Q3TPI1
resolver
uniprot
Q6P398
resolver
uniprot
Q80TA3
resolver
uniprot
Q9CQN9
resolver
uniprot
Q9CX65
resolver
uniprot_entry
A0A0J9YUC9_MOUSE
resolver
uniprot_entry
A0A338P6K5_MOUSE
resolver
uniprot_entry
E9Q1L5_MOUSE
resolver
uniprot_entry
F7DCK9_MOUSE
resolver
uniprot_entry
Q3TPI1_MOUSE
resolver
uniprot_entry
Q9CQN9_MOUSE
resolver
uniprot_entry
Q9CX65_MOUSE
resolver
uniprot_entry
SENP7_MOUSE
resolver
uniprot_sec
Q6P398
resolver
uniprot_sec
Q80TA3
resolver
amino_acid_sequence
MDRARPGRRRASSEIVTEGKRKKSSPADLQKITKLLTVKSEDVLAQSPLSKLRGSECWWTRSLRNKVICLDHKKPKAARGCPPKGLPKRHLRVMLTNVLWTDLGREFRKTLPRKDANLCAPSKVQSDSLPSTSVDSIETCQRLDPLHQSLNLSERTPRVILTDIRQTELGRKYLKIPPVTEASLSDTANLKSEQLSSSSDGSLESCQSVNHHKSFLSESGPKPSRTGDVPAKEAACGGQKQGDDGGVTPEMAAPHPKDFNTGNKGCDYLEEGTSNKNTSYSYSEMDHTPVSRKRKKRGRSNFHDSHNSKTSLDKPTEHTKEEENDSSVSRKLEESGEDSHQDPAPPEGLAPESLESEATNLRSFAAGQEPDASAASGRASSPNKSLESSASSEVSENSSVAVKGEALTLKEASPPGGSSEESQLLISAEPIVVSSDEEGPVEHKNSVILKLQPPHEIMSENQGTSDPQLSELTLGACESVQVTSELFPYNPDVENISCIKSNSEMDLKLDFIFTCVYIGKIKGTPKGCVTFTKKYIKIPFQVSTNEISLTVDTARLKRFGLWESKDEDHSKRSHAILFLWLSSDYLQDIQTQLENPMLSQQSKANEFIFLELNSSISQREELKLKDIMMEISTKNGNLHLSCPLPWVQALPLFQDLSPQEISFLHYYYASASALPTAAGADMKKKSVSQPSNSDTIKPTYTFLHKQSSGCYSLSITSSPEEEWQEVRNTGPVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIIDFYLKYLLLEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPDLSVAQRRHRRVRTWTRHINIFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDCPQTVSQQFQGQQSQHDHKMTDNDPHTTSTVSTSAEDSQSTEVNMSVPKKMCKRPCILILDSLKAASIQNTVQNLREYLEVEWEVKRKTHREFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFQDPIVNFELPIHLEKWFPRHVIKTKREDIRELILKLHLQQQKGGSC
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
function
FUNCTION: Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS (PubMed:28095500). Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (PubMed:28095500). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (By similarity). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (By similarity). Has very low efficiency in processing full-length SUMO proteins to their mature forms (By similarity). {ECO:0000250|UniProtKB:Q9BQF6, ECO:0000269|PubMed:28095500}.
uniprot
proteins
mass_dalton
116346
uniprot
proteins
mutagenesis
MUTAGEN 979; /note="C->S: Abolished protease activity and ability to desumoylate CGAS."; /evidence="ECO:0000269|PubMed:28095500
uniprot
proteins
protein_family
Peptidase C48 family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28095500
uniprot
proteins
sequence_length
1037
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28095500}.
uniprot
proteins