IL36A
entrez
27179
canonical
uniprot
Q9UHA7
canonical
ensembl
ENSG00000136694
resolver
ensp
ENSP00000259211
resolver
enst
ENST00000259211
resolver
genesymbol
IL36A
resolver
genesymbol_syn
FIL1E
resolver
genesymbol_syn
IL1E
resolver
genesymbol_syn
IL1F6
resolver
hgnc
HGNC:15562
resolver
uniprot
B2RAD9
resolver
uniprot
Q53SR7
resolver
uniprot
Q5BLR4
resolver
uniprot
Q7RTZ8
resolver
uniprot_entry
IL36A_HUMAN
resolver
uniprot_sec
B2RAD9
resolver
uniprot_sec
Q53SR7
resolver
uniprot_sec
Q5BLR4
resolver
uniprot_sec
Q7RTZ8
resolver
amino_acid_sequence
MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
uniprot
proteins
function
FUNCTION: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF, IL-8 and IL-6. In cultured monocytes up-regulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by up-regulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in pro-inflammatory effects in the lung. {ECO:0000269|PubMed:14734551, ECO:0000269|PubMed:21881584, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:24829417}.
uniprot
proteins
mass_dalton
17684
uniprot
proteins
post_translational_modification
PTM: N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold). {ECO:0000269|PubMed:21965679}.
uniprot
proteins
protein_family
IL-1 family
uniprot
proteins
pubmed
10625660
uniprot
proteins
pubmed
11466363
uniprot
proteins
pubmed
11991722
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14734551
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16777052
uniprot
proteins
pubmed
21881584
uniprot
proteins
pubmed
21965679
uniprot
proteins
pubmed
24829417
uniprot
proteins
pubmed
32272059
uniprot
proteins
sequence_length
158
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:32272059}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000269|PubMed:32272059}.
uniprot
proteins