SMYD2
entrez
56950
canonical
uniprot
Q9NRG4
canonical
ensembl
ENSG00000143499
resolver
ensp
ENSP00000355924
resolver
ensp
ENSP00000658174
resolver
genesymbol
SMYD2
resolver
genesymbol_syn
KMT3C
resolver
hgnc
HGNC:20982
resolver
uniprot
B2R9P9
resolver
uniprot
I6L9H7
resolver
uniprot
Q4V765
resolver
uniprot
Q5VSH9
resolver
uniprot
Q96AI4
resolver
uniprot_entry
SMYD2_HUMAN
resolver
uniprot_sec
B2R9P9
resolver
uniprot_sec
I6L9H7
resolver
uniprot_sec
Q4V765
resolver
uniprot_sec
Q5VSH9
resolver
uniprot_sec
Q96AI4
resolver
amino_acid_sequence
MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.354
uniprot
proteins
function
FUNCTION: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. {ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:18065756, ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:21782458, ECO:0000269|PubMed:21880715}.
uniprot
proteins
mass_dalton
49688
uniprot
proteins
mutagenesis
MUTAGEN 187; /note="E->K: Abolishes methyltransferase activity on p53/TP53."; /evidence="ECO:0000269|PubMed:21880715"; MUTAGEN 189; /note="E->K: Strongly reduces methyltransferase activity on p53/TP53."; /evidence="ECO:0000269|PubMed:21880715"; MUTAGEN 190; /note="E->K: Strongly reduces methyltransferase activity on p53/TP53."; /evidence="ECO:0000269|PubMed:21880715"; MUTAGEN 207; /note="H->A: Abolishes methyltransferase activity."; /evidence="ECO:0000269|PubMed:17108971"; MUTAGEN 240; /note="Y->F: Abolishes methyltransferase activity."; /evidence="ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:21782458"; MUTAGEN 245; /note="Y->F: Strongly reduces methyltransferase activity on p53/TP53."; /evidence="ECO:0000269|PubMed:21880715"; MUTAGEN 252; /note="D->R: Slightly reduces methyltransferase activity on p53/TP53."; /evidence="ECO:0000269|PubMed:21880715"; MUTAGEN 253; /note="R->Q: No effect on methyltransferase activity on p53/TP53."; /evidence="ECO:0000269|PubMed:21880715"; MUTAGEN 306; /note="R->E: No effect on methyltransferase activity on p53/TP53."; /evidence="ECO:0000269|PubMed:21880715"; MUTAGEN 374; /note="Y->A: Abolishes methyltransferase activity on p53/TP53."; /evidence="ECO:0000269|PubMed:21880715"; MUTAGEN 429; /note="E->K: Reduces methyltransferase activity on p53/TP53."; /evidence="ECO:0000269|PubMed:21880715"; MUTAGEN 431; /note="E->K: Strongly reduces methyltransferase activity on p53/TP53."; /evidence="ECO:0000269|PubMed:21880715
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17108971
uniprot
proteins
pubmed
17242690
uniprot
proteins
pubmed
17805299
uniprot
proteins
pubmed
18065756
uniprot
proteins
pubmed
20870719
uniprot
proteins
pubmed
21724641
uniprot
proteins
pubmed
21782458
uniprot
proteins
pubmed
21880715
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
433
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins