ACKR5
entrez
11318
canonical
uniprot
O15218
canonical
ensembl
ENSG00000166856
resolver
ensp
ENSP00000300098
resolver
ensp
ENSP00000555474
resolver
ensp
ENSP00000626714
resolver
enst
ENST00000300098
resolver
enst
ENST00000885415
resolver
enst
ENST00000956655
resolver
genesymbol
ACKR5
resolver
genesymbol_syn
ADMR
resolver
genesymbol_syn
GPR182
resolver
hgnc
HGNC:13708
resolver
uniprot_entry
ACKR5_HUMAN
resolver
amino_acid_sequence
MSVKPSWGPGPSEGVTAVPTSDLGEIHNWTELLDLFNHTLSECHVELSQSTKRVVLFALYLAMFVVGLVENLLVICVNWRGSGRAGLMNLYILNMAIADLGIVLSLPVWMLEVTLDYTWLWGSFSCRFTHYFYFVNMYSSIFFLVCLSVDRYVTLTSASPSWQRYQHRVRRAMCAGIWVLSAIIPLPEVVHIQLVEGPEPMCLFMAPFETYSTWALAVALSTTILGFLLPFPLITVFNVLTACRLRQPGQPKSRRHCLLLCAYVAVFVMCWLPYHVTLLLLTLHGTHISLHCHLVHLLYFFYDVIDCFSMLHCVINPILYNFLSPHFRGRLLNAVVHYLPKDQTKAGTCASSSSCSTQHSIIITKGDSQPAAAAPHPEPSLSFQAHHLLPNTSPISPTQPLTPS
uniprot
proteins
function
FUNCTION: Atypical chemokine receptor that regulates chemokine levels and localization through chemokine binding, independently of activating classical ligand-induced signaling pathways such as G protein activation and Ca(2+) mobilization (PubMed:33875597, PubMed:35013216, PubMed:37554323, PubMed:38026988). Instead, it mediates chemokine sequestration, transport, or internalization to control their availability (PubMed:33875597, PubMed:35013216, PubMed:37554323, PubMed:38026988). Acts as a scavenger for a broad range of chemokines from CXC, CC and XC chemokine ligand families including CXCL9, CXCL10, CXCL12, CXCL13, CXCL11, CXCL14, CCL1, CCL11, CCL19, CCL25, CCL28 and XCL1 (PubMed:33875597, PubMed:35013216, PubMed:38026988). Is the only atypical receptor for chemokines CXCL13 and CCL28 (PubMed:37554323). Has a strong constitutive association with beta-arrestins, which is essential for intracellular receptor trafficking and chemokine scavenging, and occurs independently of ligand binding (PubMed:33875597, PubMed:37554323). Cooperates with ACKR3 and ACKR4 in regulating serum levels of CXCL12 and CCL19, respectively (PubMed:37554323). Acts as an important modulator of cellular immunity (By similarity). {ECO:0000250|UniProtKB:P43142, ECO:0000269|PubMed:33875597, ECO:0000269|PubMed:35013216, ECO:0000269|PubMed:37554323, ECO:0000269|PubMed:38026988}.
uniprot
proteins
mass_dalton
45323
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
33875597
uniprot
proteins
pubmed
35013216
uniprot
proteins
pubmed
37554323
uniprot
proteins
pubmed
38026988
uniprot
proteins
pubmed
9367907
uniprot
proteins
pubmed
9535752
uniprot
proteins
sequence_length
404
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37554323}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:37554323}; Multi-pass membrane protein {ECO:0000255}. Note=Spontaneously traffic between the plasma membrane and endosomes, in a beta-arrestin-dependent manner. {ECO:0000269|PubMed:37554323}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..79; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 91..113; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 128..149; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 171..193; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 218..239; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 259..280; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 300..320; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins