TRIM33
entrez
51592
canonical
uniprot
Q9UPN9
canonical
ensembl
ENSG00000197323
resolver
ensp
ENSP00000351250
resolver
ensp
ENSP00000358556
resolver
ensp
ENSP00000595815
resolver
ensp
ENSP00000595816
resolver
ensp
ENSP00000786329
resolver
genesymbol
TRIM33
resolver
genesymbol_syn
KIAA1113
resolver
genesymbol_syn
RFG7
resolver
genesymbol_syn
TIF1G
resolver
hgnc
HGNC:16290
resolver
uniprot
B3KN30
resolver
uniprot
O95855
resolver
uniprot
Q5TG72
resolver
uniprot
Q5TG73
resolver
uniprot
Q5TG74
resolver
uniprot
Q9C017
resolver
uniprot
Q9UJ79
resolver
uniprot_entry
B3KN30_HUMAN
resolver
uniprot_entry
TRI33_HUMAN
resolver
uniprot_sec
O95855
resolver
uniprot_sec
Q5TG72
resolver
uniprot_sec
Q5TG73
resolver
uniprot_sec
Q5TG74
resolver
uniprot_sec
Q9C017
resolver
uniprot_sec
Q9UJ79
resolver
amino_acid_sequence
MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving TRIM33 is found in papillary thyroid carcinomas (PTCs). Translocation t(1;10)(p13;q11) with RET. The translocation generates the TRIM33/RET (PTC7) oncogene. {ECO:0000269|PubMed:10439047}.; DISEASE: Developmental dysplasia of the hip 4 (DDH4) [MIM:621311]: An autosomal recessive form of congenital dysplasia of the hip, a common skeletal anomaly in which the normal seating of the femoral head in the acetabulum is disrupted. Its severity ranges from mild instability of the femoral head with slight capsular laxity, permitting minimal lateral displacement, through moderate lateral displacement of the femoral head, without loss of contact of the head with the acetabulum, up to complete dislocation of the femoral head from the acetabulum. {ECO:0000269|PubMed:39054052}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}.
uniprot
proteins
mass_dalton
122533
uniprot
proteins
mutagenesis
MUTAGEN 125; /note="C->A: Abolishes E3 activity but does not affect interaction with SMAD4; when associated with A-128."; /evidence="ECO:0000269|PubMed:15820681"; MUTAGEN 128; /note="C->A: Abolishes E3 activity but does not affect interaction with SMAD4; when associated with A-125."; /evidence="ECO:0000269|PubMed:15820681
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Sumoylated with SUMO1. {ECO:0000250|UniProtKB:Q99PP7}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
10022127
uniprot
proteins
pubmed
10439047
uniprot
proteins
pubmed
10470851
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
12096914
uniprot
proteins
pubmed
15820681
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16751102
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19135894
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25593309
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
39054052
uniprot
proteins
sequence_length
1127
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894, ECO:0000269|PubMed:25593309}. Note=In discrete nuclear dots resembling nuclear bodies (By similarity). Localizes to sites of DNA damage (PubMed:25593309). {ECO:0000250|UniProtKB:Q99PP7, ECO:0000269|PubMed:25593309}.
uniprot
proteins