FAM8A1
entrez
51439
canonical
uniprot
Q9UBU6
canonical
ensembl
ENSG00000137414
resolver
ensp
ENSP00000259963
resolver
enst
ENST00000259963
resolver
genesymbol
FAM8A1
resolver
genesymbol_syn
AHCP
resolver
hgnc
HGNC:16372
resolver
uniprot
B2R725
resolver
uniprot_entry
FA8A1_HUMAN
resolver
uniprot_sec
B2R725
resolver
amino_acid_sequence
MAEGPEEARGHPPGQDDGGGDHEPVPSLRGPPTTAVPCPRDDPQAEPQAPGRPTAPGLAAAAAADKLEPPRELRKRGEAASGSGAELQEQAGCEAPEAAAPRERPARLSAREYSRQVHEWLWQSYCGYLTWHSGLAAFPAYCSPQPSPQSFPSGGAAVPQAAAPPPPQLGYYNPFYFLSPGAAGPDPRTAAGISTPAPVAGLGPRAPHVQASVRATPVTRVGSAAPSRSPSETGRQAGREYVIPSLAHRFMAEMVDFFILFFIKATIVLSIMHLSGIKDISKFAMHYIIEEIDEDTSMEDLQKMMVVALIYRLLVCFYEIICIWGAGGATPGKFLLGLRVVTCDTSVLIAPSRVLVIPSSNVSITTSTIRALIKNFSIASFFPAFITLLFFQHNRTAYDIVAGTIVVKRNGVR
uniprot
proteins
function
FUNCTION: Plays a role in the assembly of the HRD1 complex, a complex involved in the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD). {ECO:0000269|PubMed:28827405}.
uniprot
proteins
mass_dalton
44123
uniprot
proteins
mutagenesis
MUTAGEN 120..122; /note="WLW->ALA: Decreased interaction with SYVN1 and HERPUD1."; /evidence="ECO:0000269|PubMed:28827405"; MUTAGEN 131; /note="W->A: Decreased interaction with HERPUD1; no effect on interaction with SYVN1."; /evidence="ECO:0000269|PubMed:28827405
uniprot
proteins
pubmed
11707071
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28827405
uniprot
proteins
sequence_length
413
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 257..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 304..324; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 371..391; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins