TCP11
entrez
6954
canonical
uniprot
Q8WWU5
canonical
ensembl
ENSG00000124678
resolver
ensp
ENSP00000244645
resolver
ensp
ENSP00000308708
resolver
ensp
ENSP00000363085
resolver
ensp
ENSP00000402816
resolver
ensp
ENSP00000404479
resolver
ensp
ENSP00000415320
resolver
ensp
ENSP00000422105
resolver
ensp
ENSP00000478603
resolver
enst
ENST00000444780
resolver
genesymbol
TCP11
resolver
hgnc
HGNC:11658
resolver
uniprot
A0A6E1WXZ9
resolver
uniprot
B2RCE9
resolver
uniprot
B3KQ27
resolver
uniprot
B7Z7B5
resolver
uniprot
B7Z7G1
resolver
uniprot
B7Z7H4
resolver
uniprot
B7Z7S8
resolver
uniprot
B7ZAT8
resolver
uniprot
E7EP29
resolver
uniprot
J3KNG1
resolver
uniprot
Q8NF85
resolver
uniprot
Q9NQZ9
resolver
uniprot
Q9NR39
resolver
uniprot_entry
A0A6E1WXZ9_HUMAN
resolver
uniprot_entry
B7ZAT8_HUMAN
resolver
uniprot_entry
TCP11_HUMAN
resolver
uniprot_sec
B2RCE9
resolver
uniprot_sec
B3KQ27
resolver
uniprot_sec
B7Z7B5
resolver
uniprot_sec
B7Z7G1
resolver
uniprot_sec
B7Z7H4
resolver
uniprot_sec
B7Z7S8
resolver
uniprot_sec
E7EP29
resolver
uniprot_sec
J3KNG1
resolver
uniprot_sec
Q8NF85
resolver
uniprot_sec
Q9NQZ9
resolver
uniprot_sec
Q9NR39
resolver
amino_acid_sequence
MPDVKESVPPKYPGDSEGRSCKPETSGPPQEDKSGSEDPPPFLSVTGLTETVNEVSKLSNKIGMNCDYYMEEKVLPPSSLEGKVKETVHNAFWDHLKEQLSATPPDFSCALELLKEIKEILLSLLLPRQNRLRIEIEEALDMDLLKQEAEHGALKVLYLSKYVLNMMALLCAPVRDEAVQKLENITDPVWLLRGIFQVLGRMKMDMVNYTIQSLQPHLQEHSIQYERAKFQELLNKQPSLLNHTTKWLTQAAGDLTMSPPTCPDTSDSSSVAGPSPNEAANNPEPLSPTMVLCQGFLNLLLWDLENEEFPETLLMDRTRLQELKSQLHQLTVMASVLLVASSFSGSVLFGSPQFVDKLKRITKSLLEDFHSRPEEAILTVSEQVSQEIHQSLKNMGLVALSSDNTASLMGQLQNIAKKENCVCSVIDQRIHLFLKCCLVLGVQRSLLDLPGGLTLIEAELAELGQKFVNLTHHNQQVFGPYYTEILKTLISPAQALETKVESV
uniprot
proteins
function
FUNCTION: Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway. {ECO:0000250|UniProtKB:Q01755}.
uniprot
proteins
mass_dalton
56141
uniprot
proteins
post_translational_modification
PTM: Constitutively phosphorylated on serine, threonine and tyrosine residues within the head and tail regions of noncapacitated spermatozoa. Phosphorylation on tyrosine residues increases upon sperm capacitation within the acrosomal region in a protein kinase A (PKA)-dependent signaling pathway. {ECO:0000250|UniProtKB:Q01755}.
uniprot
proteins
protein_family
TCP11 family
uniprot
proteins
pubmed
11756566
uniprot
proteins
pubmed
12545228
uniprot
proteins
pubmed
12905703
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21597245
uniprot
proteins
sequence_length
503
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q01755}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q01755}. Note=Localizes on the acrosomal cap region of acrosome-intact, but not acrosome-reacted sperm. Colocalizes with MROH2B and PRKACA on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm. {ECO:0000250|UniProtKB:Q01755}.
uniprot
proteins
transmembrane_region
TRANSMEM 330..349; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins