Senp2
entrez
78973
canonical
uniprot
Q9EQE1
canonical
ensembl
ENSRNOG00000001773
resolver
ensp
ENSRNOP00000002425
resolver
ensp
ENSRNOP00000071258
resolver
enst
ENSRNOT00000087105
resolver
genesymbol
Senp2
resolver
uniprot
A0A0G2K009
resolver
uniprot_entry
A0A0G2K009_RAT
resolver
uniprot_entry
SENP2_RAT
resolver
amino_acid_sequence
MYRWLTKVLGTILRLCERPAPGARALLKRRRSSSSLFSTAVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVSSACNGTRNVAPSGEVFSNSPSCELTTSGSCSSMLKLGNKSPNGISDYPKIRVTVARDQPRRVLPSFGFTLKSEGYNRRPSGRRHSKSNPESSLPWKPQEQGVTEMISEEGGKGARRPHCTVEEGVQKDEREKYLKLLERLKEGAHGSTFPPAVSHHSSQRTQMDTLKTKGWMEEQNHGVRTTHLVPKQYRVVETRGPLCSVRSEKRYSKGKADTEKVVGLRFEKDGTRGHQLEPDLSEEVSARLRLGSGSNGLLRRKISVLEAKEKNFPSKEKDRRTEDLFELTEDMEKEISNALGHGPPDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERSKKQGYPALHALSTFFYPKLKSGGYQAVKRWTKGVNLFDQELVLVPIHRKVHWSLVVMDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNTDLNLLEWTHYSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
function
FUNCTION: Protease that catalyzes two essential functions in the SUMO pathway (By similarity). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (By similarity). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (By similarity). May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (PubMed:10944533, PubMed:11997515). Deconjugates SUMO2 from MTA1 (By similarity). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (By similarity). Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity). {ECO:0000250|UniProtKB:Q91ZX6, ECO:0000250|UniProtKB:Q9HC62, ECO:0000269|PubMed:10944533, ECO:0000269|PubMed:11997515}.
uniprot
proteins
mass_dalton
67252
uniprot
proteins
mutagenesis
MUTAGEN 547; /note="C->S: Abolishes protease activity."; /evidence="ECO:0000269|PubMed:11997515
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated; which leads to proteasomal degradation. {ECO:0000250|UniProtKB:Q9HC62}.
uniprot
proteins
protein_family
Peptidase C48 family
uniprot
proteins
pubmed
10944533
uniprot
proteins
pubmed
11997515
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q9HC62}. Nucleus membrane {ECO:0000250|UniProtKB:Q9HC62}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9HC62}; Nucleoplasmic side {ECO:0000250|UniProtKB:Q9HC62}. Cytoplasm {ECO:0000250|UniProtKB:Q9HC62}. Note=Shuttles between cytoplasm and nucleus. {ECO:0000250|UniProtKB:Q9HC62}.
uniprot
proteins