Hipk3
entrez
83617
canonical
uniprot
O88850
canonical
ensembl
ENSRNOG00000011358
resolver
ensp
ENSRNOP00000015775
resolver
ensp
ENSRNOP00000085704
resolver
enst
ENSRNOT00000015775
resolver
enst
ENSRNOT00000105868
resolver
genesymbol
Hipk3
resolver
genesymbol_syn
Fist
resolver
uniprot
A0A8I6GE65
resolver
uniprot
A0ACM8Q8D3
resolver
uniprot
F7EY07
resolver
uniprot
Q498U5
resolver
uniprot_entry
A0A8I6GE65_RAT
resolver
uniprot_entry
A0ACM8Q8D3_RAT
resolver
uniprot_entry
HIPK3_RAT
resolver
uniprot_entry
Q498U5_RAT
resolver
uniprot_sec
F7EY07
resolver
amino_acid_sequence
MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSGCVFQERACPQIHVNGRHFGNPLPSTKGSAFQTKIPFSKPRGHSFSLQAGAIVVKDTAGATKVIAAQAQQAGVEAPRAVVWRNRLHFLGGPQRCGLKRKSEELDNHSGAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTSGEGDYQLVQHEVLCSVKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDIVHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPIETLNHPFVSMKHLLDFPHSSHVKSCFHIMDICKSPSSCETNNHSKMSLLRPVASNGTAALAANFTKVGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFHQTLIICPPAIQGIPAAHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQTWSGRTQQMLIPAWQQVTPMAPAAATLTSEGMAGSQRLGDWGKMIPHSNHYNSVMPPPLLTNQITLSAPQPISVGIAHVVWPQPATTKKNKLCQNRSNSLQNTNVPHSAFISPKIISGKEVEEVSCVETQDNHTSEGEARTCHEASVRQDSSVSDKQRQTIIIADSPSPAVSVITISSDTDDEETSPRPSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDDEQESGCETVDGSPTSDSSGHDSPFAESSFVEDTPQNPELGTCAGTEAKPALSTAVEPPVGTERGLNVDAHMANTDSTCQPLTKGQPAPGKLNQPSASAARQQKPTSAFQQQHLNLSQVQHFGTGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGSAHLGGQPTLLPYPPSTALSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGINPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. {ECO:0000269|PubMed:9725910}.
uniprot
proteins
mass_dalton
129744
uniprot
proteins
mutagenesis
MUTAGEN 226; /note="K->R: No enzymatic activity."; /evidence="ECO:0000269|PubMed:9725910"; MUTAGEN 357; /note="S->A: Reduces enzymatic activity but no effect on autophosphorylation; when associated with A-359."; /evidence="ECO:0000269|PubMed:9725910"; MUTAGEN 359; /note="Y->A: Reduces enzymatic activity; but no effect on autophosphorylation; when associated with A-357."; /evidence="ECO:0000269|PubMed:9725910
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Autophosphorylation is not required for catalytic activity.; PTM: May be sumoylated. {ECO:0000250}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
HIPK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
9725910
uniprot
proteins
sequence_length
1191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9725910}.
uniprot
proteins