Avpr1a
entrez
25107
canonical
uniprot
P30560
canonical
ensembl
ENSRNOG00000004400
resolver
ensembl
ENSRNOG00055026240
resolver
ensembl
ENSRNOG00060008510
resolver
ensembl
ENSRNOG00065016788
resolver
ensp
ENSRNOP00000005829
resolver
ensp
ENSRNOP00055037135
resolver
ensp
ENSRNOP00060010913
resolver
ensp
ENSRNOP00065022125
resolver
enst
ENSRNOT00000005829
resolver
enst
ENSRNOT00055045304
resolver
enst
ENSRNOT00060014217
resolver
enst
ENSRNOT00065028008
resolver
genesymbol
Avpr1a
resolver
uniprot
Q5M8D1
resolver
uniprot
Q62874
resolver
uniprot
Q9QW18
resolver
uniprot_entry
V1AR_RAT
resolver
uniprot_sec
Q5M8D1
resolver
uniprot_sec
Q62874
resolver
uniprot_sec
Q9QW18
resolver
amino_acid_sequence
MSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFILSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGFICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFIPVST
uniprot
proteins
function
FUNCTION: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation. {ECO:0000269|PubMed:12887422}.
uniprot
proteins
mass_dalton
47655
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="N->Q: Reduced ligand binding affinity."; /evidence="ECO:0000269|PubMed:11520055"; MUTAGEN 27; /note="N->Q: Reduced ligand binding affinity."; /evidence="ECO:0000269|PubMed:11520055"; MUTAGEN 115; /note="Y->D: No significant change in affinity for arginine vasopressin or oxytocin. Increased affinity for 1-deamino, D-Arg8-vasopressin."; /evidence="ECO:0000269|PubMed:7774575"; MUTAGEN 115; /note="Y->F: 17-fold increase in affinity for oxytocin. No change in affinity for arginine vasopressin or 1-deamino, D-Arg8-vasopressin."; /evidence="ECO:0000269|PubMed:7774575"; MUTAGEN 115; /note="Y->L: 50-fold decrease in affinity for arginine vasopressin. Little affect on affinity for oxytocin or 1-deamino, D-Arg8-vasopressin."; /evidence="ECO:0000269|PubMed:7774575"; MUTAGEN 371; /note="C->G: Reduced palmitoylation, coupling to G protein unaffected. Abolished isoprenylation, coupling to G protein unaffected; when associated with G-372."; /evidence="ECO:0000269|PubMed:11466323"; MUTAGEN 372; /note="C->G: Reduced palmitoylation, coupling to G protein unaffected. Abolished isoprenylation, coupling to G protein unaffected; when associated with G-371."; /evidence="ECO:0000269|PubMed:11466323
uniprot
proteins
post_translational_modification
PTM: Palmitoylated on three cysteine residues, of which only two are identified. {ECO:0000269|PubMed:11466323}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Vasopressin/oxytocin receptor subfamily
uniprot
proteins
pubmed
11466323
uniprot
proteins
pubmed
11520055
uniprot
proteins
pubmed
12399435
uniprot
proteins
pubmed
12887422
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1560825
uniprot
proteins
pubmed
7774575
uniprot
proteins
pubmed
8257445
uniprot
proteins
pubmed
8511367
uniprot
proteins
pubmed
8670090
uniprot
proteins
pubmed
9105680
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Located in cytoplasmic vesicles dispersed throughout the cell cytoplasm and to the plasma membrane.
uniprot
proteins
transmembrane_region
TRANSMEM 53..76; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 89..110; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 126..147; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 169..190; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 221..241; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 300..319; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 338..357; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins