Tapbpl
entrez
213233
canonical
uniprot
Q8VD31
canonical
ensembl
ENSMUSG00000038213
resolver
ensp
ENSMUSP00000047105
resolver
enst
ENSMUST00000043422
resolver
genesymbol
Tapbpl
resolver
uniprot
E9QN33
resolver
uniprot_entry
TPSNR_MOUSE
resolver
uniprot_sec
E9QN33
resolver
amino_acid_sequence
MGLEPSWYLLLCLAVSGAAGTDPPTAPTTAERQRQPTDIILDCFLVTEDRHRGAFASSGDRERALLVLKQVPVLDDGSLEGITDFQGSTETKQDSPVIFEASVDLVQIPQAEALLHADCSGKAVTCEISKYFLQARQEATFEKAHWFISNMQVSRGGPSVSMVMKTLRDAEVGAVRHPTLNLPLSAQGTVKTQVEFQVTSETQTLNHLLGSSVSLHCSFSMAPGLDLTGVEWRLQHKGSGQLVYSWKTGQGQAKRKGATLEPEELLRAGNASLTLPNLTLKDEGNYICQISTSLYQAQQIMPLNILAPPKIQLHLANKDPLPSLVCSIAGYYPLDVGVTWIREELGGIPAQVSGASFSSLRQSTMGTYSISSTVMADPGPTGATYTCQVAHVSLEEPLTTSMRVLPNPEQRGTLGVIFASIIFLSALLLFLGLHRQQASSSRSTRPMRHSG
uniprot
proteins
function
FUNCTION: Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression. {ECO:0000250|UniProtKB:Q9BX59}.
uniprot
proteins
mass_dalton
48733
uniprot
proteins
pubmed
11920573
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
451
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BX59}; Single-pass type I membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BX59}; Single-pass type I membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250|UniProtKB:Q9BX59}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9BX59}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9BX59}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9BX59}. Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface. {ECO:0000250|UniProtKB:Q9BX59}.
uniprot
proteins
transmembrane_region
TRANSMEM 413..433; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins