Hnrnpc
entrez
15381
canonical
uniprot
Q9Z204
canonical
ensembl
ENSMUSG00000060373
resolver
ensp
ENSMUSP00000107237
resolver
ensp
ENSMUSP00000154166
resolver
ensp
ENSMUSP00000154212
resolver
ensp
ENSMUSP00000154238
resolver
ensp
ENSMUSP00000154619
resolver
ensp
ENSMUSP00000154737
resolver
ensp
ENSMUSP00000154757
resolver
ensp
ENSMUSP00000176532
resolver
ensp
ENSMUSP00000176533
resolver
ensp
ENSMUSP00000176534
resolver
ensp
ENSMUSP00000176535
resolver
ensp
ENSMUSP00000176536
resolver
ensp
ENSMUSP00000176538
resolver
ensp
ENSMUSP00000176540
resolver
ensp
ENSMUSP00000176543
resolver
ensp
ENSMUSP00000176545
resolver
ensp
ENSMUSP00000176550
resolver
ensp
ENSMUSP00000176554
resolver
ensp
ENSMUSP00000176559
resolver
ensp
ENSMUSP00000176560
resolver
ensp
ENSMUSP00000176564
resolver
ensp
ENSMUSP00000176566
resolver
ensp
ENSMUSP00000176567
resolver
ensp
ENSMUSP00000352477
resolver
genesymbol
Hnrnpc
resolver
genesymbol_syn
Hnrpc
resolver
uniprot
Q3TLB5
resolver
uniprot
Q501Q3
resolver
uniprot
Q8C2G5
resolver
uniprot
Q99KE2
resolver
uniprot
Q9CQT3
resolver
uniprot
Q9CY83
resolver
uniprot_entry
HNRPC_MOUSE
resolver
uniprot_sec
Q3TLB5
resolver
uniprot_sec
Q501Q3
resolver
uniprot_sec
Q8C2G5
resolver
uniprot_sec
Q99KE2
resolver
uniprot_sec
Q9CQT3
resolver
uniprot_sec
Q9CY83
resolver
amino_acid_sequence
MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAAEPKVNRGKAGVKRSAAEMYGSVPEHPSPSPLLSSSFDLDYDFQRDYYDRMYSYPARVPPPPPIARAVVPSKRQRVSGNTSRRGKSGFNSKSGQRGSSSKSGKLKGDDLQAIKKELTQIKQKVDSLLESLEKIEKEQSKQADLSFSSPVEMKNEKSEEEQSSASVKKDETNVKMESEAGADDSAEEGDLLDDDDNEDRGDDQLELKDDEKEPEEGEDDRDSANGEDDS
uniprot
proteins
function
FUNCTION: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing. {ECO:0000250|UniProtKB:P07910}.
uniprot
proteins
mass_dalton
34385
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-268 and Ser-306 in resting cells. {ECO:0000250|UniProtKB:P07910}.; PTM: Sumoylated. Sumoylation reduces affinity for mRNA. {ECO:0000250|UniProtKB:P07910}.; PTM: Ubiquitinated and degraded after nucleo-cytoplasmic transport by YWHAE. {ECO:0000250|UniProtKB:P07910}.
uniprot
proteins
protein_family
RALY subfamily
uniprot
proteins
protein_family
RRM HNRPC family
uniprot
proteins
pubmed
10805751
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P07910}. Note=Component of ribonucleosomes. {ECO:0000250|UniProtKB:P07910}.
uniprot
proteins