PCMTD1
entrez
115294
canonical
uniprot
Q96MG8
canonical
ensembl
ENSG00000168300
resolver
ensp
ENSP00000428099
resolver
ensp
ENSP00000444026
resolver
ensp
ENSP00000667052
resolver
genesymbol
PCMTD1
resolver
hgnc
HGNC:30483
resolver
uniprot
B7Z927
resolver
uniprot
F5H1M8
resolver
uniprot
Q96FK9
resolver
uniprot_entry
B7Z927_HUMAN
resolver
uniprot_entry
PCMD1_HUMAN
resolver
uniprot_sec
F5H1M8
resolver
uniprot_sec
Q96FK9
resolver
amino_acid_sequence
MGGAVSAGEDNDDLIDNLKEAQYIRTERVEQAFRAIDRGDYYLEGYRDNAYKDLAWKHGNIHLSAPCIYSEVMEALKLQPGLSFLNLGSGTGYLSTMVGLILGPFGINHGIELHSDVVEYAKEKLESFIKNSDSFDKFEFCEPAFVVGNCLQIASDSHQYDRIYCGAGVQKDHENYMKILLKVGGILVMPIEDQLTQIMRTGQNTWESKNILAVSFAPLVQPSKNDNGKPDSVGLPPCAVRNLQDLARIYIRRTLRNFINDEMQAKGIPQRAPPKRKRKRVKQRINTYVFVGNQLIPQPLDSEEDEKMEEDNKEEEEKDHNEAMKPEEPPQNLLREKIMKLPLPESLKAYLTYFRDK
uniprot
proteins
function
FUNCTION: Substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:35486881). Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity (PubMed:35486881). May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein (PubMed:35486881). {ECO:0000269|PubMed:35486881}.
uniprot
proteins
mass_dalton
40675
uniprot
proteins
protein_family
L-isoaspartyl/D-aspartyl protein methyltransferase family
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
25807930
uniprot
proteins
pubmed
35486881
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P22061}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
uniprot
proteins