ALOX5AP
entrez
241
canonical
uniprot
P20292
canonical
ensembl
ENSG00000132965
resolver
ensp
ENSP00000369858
resolver
ensp
ENSP00000479870
resolver
ensp
ENSP00000562394
resolver
enst
ENST00000380490
resolver
enst
ENST00000617770
resolver
enst
ENST00000892335
resolver
genesymbol
ALOX5AP
resolver
genesymbol_syn
FLAP
resolver
hgnc
HGNC:436
resolver
uniprot
A0A087WW23
resolver
uniprot
Q5VV04
resolver
uniprot_entry
A0A087WW23_HUMAN
resolver
uniprot_entry
AL5AP_HUMAN
resolver
uniprot_sec
Q5VV04
resolver
amino_acid_sequence
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
uniprot
proteins
disease_involvement
DISEASE: Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. {ECO:0000269|PubMed:14770184, ECO:0000269|PubMed:17304054}.
uniprot
proteins
function
FUNCTION: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. {ECO:0000269|PubMed:2300173, ECO:0000269|PubMed:8440384}.
uniprot
proteins
mass_dalton
18157
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="V->A: Increased affinity for the inhibitor MK-591."; /evidence="ECO:0000269|PubMed:17600184"; MUTAGEN 27; /note="A->V: Strongly decreased affinity for the inhibitor MK-591."; /evidence="ECO:0000269|PubMed:17600184"; MUTAGEN 30; /note="V->A: Strongly decreased affinity for the inhibitor MK-591."; /evidence="ECO:0000269|PubMed:17600184"; MUTAGEN 62; /note="D->A: Decreased affinity for the inhibitor MK-591."; /evidence="ECO:0000269|PubMed:17600184"; MUTAGEN 66; /note="T->A: Strongly decreased affinity for the inhibitor MK-591."; /evidence="ECO:0000269|PubMed:17600184"; MUTAGEN 112; /note="Y->A: Strongly decreased affinity for the inhibitor MK-591."; /evidence="ECO:0000269|PubMed:17600184"; MUTAGEN 113; /note="I->A: Increased affinity for the inhibitor MK-591."; /evidence="ECO:0000269|PubMed:17600184"; MUTAGEN 116; /note="K->A: Strongly increased affinity for the inhibitor MK-591."; /evidence="ECO:0000269|PubMed:17600184"; MUTAGEN 123; /note="F->A: Decreased affinity for the inhibitor MK-591."; /evidence="ECO:0000269|PubMed:17600184
uniprot
proteins
protein_family
MAPEG family
uniprot
proteins
pubmed
14770184
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1673682
uniprot
proteins
pubmed
17304054
uniprot
proteins
pubmed
17600184
uniprot
proteins
pubmed
19233132
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2300173
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
8245774
uniprot
proteins
pubmed
8440384
uniprot
proteins
sequence_length
161
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 9..30; /note="Helical"; TRANSMEM 53..77; /note="Helical"; TRANSMEM 81..102; /note="Helical"; TRANSMEM 116..128; /note="Helical
uniprot
proteins