Rbm15
entrez
229700
canonical
uniprot
Q0VBL3
canonical
ensembl
ENSMUSG00000048109
resolver
ensp
ENSMUSP00000054424
resolver
genesymbol
Rbm15
resolver
genesymbol_syn
Kiaa4257
resolver
genesymbol_syn
Ott1
resolver
uniprot
A0PJG5
resolver
uniprot
Q3THK4
resolver
uniprot
Q3TLX0
resolver
uniprot
Q571M7
resolver
uniprot
Q66JP8
resolver
uniprot
Q6PGG1
resolver
uniprot
Q7TT82
resolver
uniprot_entry
RBM15_MOUSE
resolver
uniprot_sec
A0PJG5
resolver
uniprot_sec
Q3THK4
resolver
uniprot_sec
Q3TLX0
resolver
uniprot_sec
Q571M7
resolver
uniprot_sec
Q66JP8
resolver
uniprot_sec
Q6PGG1
resolver
uniprot_sec
Q7TT82
resolver
amino_acid_sequence
MRSAGREPLPRRSPRWRRASPLCETSAGWRVSQLRRDDLRRPSTMKGKERSPVKPKRSRGGEDSSSRGERSKKLGGSGGSNGSSSGKTDSGGSRRSLHLDKSSSRGGSREYETGGGSSSSRLHSYSSPSTKNSSGGGESRSSSRGGGGESRSSGAASSAPGGGDGVEYKTLKISELGSQLSDEAVEDGLFHEFKRFGDVSVKISHLSGSGSGDERVAFVNFRRPEDARAAKHARGRLVLYDRPLKIEAVYVSRRRSRSPLDKDAYAPSSSVVGTSVGSHRHAPGGGGGQRSLSPGGAALGYRDYRLQQLALGRLPPPPPPPLPRELERERDYPFYDRVRPAYSLEPRVGAGAGAAPFREVDEISPEDDQRANRTLFLGNLDITVTENDLRRAFDRFGVITEVDIKRPSRGQTSTYGFLKFENLDMSHRAKLAMSGKIIIRNPIKIGYGKATPTTRLWVGGLGPWVPLAALAREFDRFGTIRTIDYRKGDSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFADTEHRYQQQYLQPLPLTHYELVTDTFGHRAPDPLRSARDRTPPLLYRDRDRDLYTDSDWVPPPPPVRERSARAATSAVTAYEPLDSLDRRRDGWSLDRDRGDRDLPSSRDQPRKRRLPEESGGRHLDRSPESERPRKQRHCTPSPDRSPELSSNRDRYNSDNDRSSRLLLLERSSPVRDRRGSLEKSQSDKRDRKNSASAERDRKHRTAAPTEGKNPLKKEDRSDGNAPSASTSSSKQKPPSQKQDGGTAPVAASSPKLCLAWQGMLLLKNSNFPSNMHLLQGDLQVASSLLVEGSTGGKVAQLKITQRLRLDQPKLDEVTRRIKVAGPNGYAILLAVPGSSDSRSSSSSATSDTAASTQRPLRNLVSYLKQKQAAGVISLPVGGNKDKENTGVLHAFPPCEFSQQFLDSPAKALAKSEEDYLVMIIVRAKLVNSG
uniprot
proteins
function
FUNCTION: RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:29535189). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:29535189). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (By similarity). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (PubMed:17283045, PubMed:17376872, PubMed:18981216, PubMed:25468569). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (By similarity). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (PubMed:18981216). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (PubMed:25468569). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (By similarity). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (By similarity). May be implicated in HOX gene regulation (By similarity). {ECO:0000250|UniProtKB:Q96T37, ECO:0000269|PubMed:17283045, ECO:0000269|PubMed:17376872, ECO:0000269|PubMed:18981216, ECO:0000269|PubMed:25468569, ECO:0000269|PubMed:29535189}.
uniprot
proteins
mass_dalton
105722
uniprot
proteins
post_translational_modification
PTM: Methylated at Arg-577 by PRMT1, leading to promote ubiquitination by CNOT4 and subsequent degradation by the proteasome. {ECO:0000250|UniProtKB:Q96T37}.; PTM: Ubiquitinated by CNOT4 following methylation at Arg-577 by PRMT1. {ECO:0000250|UniProtKB:Q96T37}.
uniprot
proteins
protein_family
RRM Spen family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17283045
uniprot
proteins
pubmed
17376872
uniprot
proteins
pubmed
18981216
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25468569
uniprot
proteins
pubmed
29535189
uniprot
proteins
sequence_length
962
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q96T37}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17283045}. Nucleus envelope {ECO:0000250|UniProtKB:Q96T37}. Nucleus membrane {ECO:0000250|UniProtKB:Q96T37}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96T37}. Note=Colocalizes at the nuclear pore with DBP5 and NXF1. {ECO:0000250|UniProtKB:Q96T37}.
uniprot
proteins