Sumo2
entrez
690244
canonical
uniprot
P61959
canonical
ensembl
ENSRNOG00055032360
resolver
ensembl
ENSRNOG00060022711
resolver
ensembl
ENSRNOG00065019848
resolver
ensp
ENSRNOP00055046033
resolver
ensp
ENSRNOP00060032646
resolver
ensp
ENSRNOP00065026771
resolver
enst
ENSRNOT00055055872
resolver
enst
ENSRNOT00060039460
resolver
enst
ENSRNOT00065033475
resolver
genesymbol
Sumo2
resolver
genesymbol_syn
Smt3a
resolver
genesymbol_syn
Smt3h2
resolver
uniprot
P55855
resolver
uniprot_entry
SUMO2_RAT
resolver
uniprot_sec
P55855
resolver
amino_acid_sequence
MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY
uniprot
proteins
function
FUNCTION: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity). {ECO:0000250|UniProtKB:P61956}.
uniprot
proteins
mass_dalton
10871
uniprot
proteins
post_translational_modification
PTM: Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4 (By similarity). {ECO:0000250}.; PTM: Cleavage of precursor form by SENP1 or SENP2 is necessary for function. {ECO:0000250}.; PTM: Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer. {ECO:0000250}.
uniprot
proteins
protein_family
SUMO subfamily
uniprot
proteins
protein_family
Ubiquitin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
95
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}.
uniprot
proteins