Cmklr2
entrez
25457
canonical
uniprot
P46090
canonical
ensembl
ENSRNOG00000045532
resolver
ensembl
ENSRNOG00055022234
resolver
ensembl
ENSRNOG00060019975
resolver
ensembl
ENSRNOG00065026428
resolver
ensp
ENSRNOP00000067327
resolver
ensp
ENSRNOP00000102895
resolver
ensp
ENSRNOP00000104826
resolver
ensp
ENSRNOP00000105703
resolver
ensp
ENSRNOP00000106796
resolver
ensp
ENSRNOP00000109323
resolver
ensp
ENSRNOP00055031120
resolver
ensp
ENSRNOP00060028348
resolver
ensp
ENSRNOP00065037400
resolver
enst
ENSRNOT00000072737
resolver
enst
ENSRNOT00000123700
resolver
enst
ENSRNOT00000129683
resolver
enst
ENSRNOT00000147065
resolver
enst
ENSRNOT00000156612
resolver
enst
ENSRNOT00000174111
resolver
enst
ENSRNOT00055038210
resolver
enst
ENSRNOT00060034524
resolver
enst
ENSRNOT00065045610
resolver
genesymbol
Cmklr2
resolver
genesymbol_syn
Gpr1
resolver
uniprot
M0RCK7
resolver
uniprot_entry
CML2_RAT
resolver
uniprot_sec
M0RCK7
resolver
amino_acid_sequence
MEVSREMLFEELDNYSYALEYYSQEPDAEENVYPGIVHWISLLLYALAFVLGIPGNAIVIWFMGFKWKKTVTTLWFLNLAIADFVFVLFLPLYISYVALSFHWPFGRWLCKLNSFIAQLNMFSSVFFLTVISLDRYIHLIHPGLSHPHRTLKNSLLVVLFVWLLASLLGGPTLYFRDTVEVNNRIICYNNFQEYELTLMRHHVLTWVKFLFGYLLPLLTMSSCYLCLIFKTKKQNILISSKHLWMILSVVIAFMVCWTPFHLFSIWELSIHHNSSFQNVLQGGIPLSTGLAFLNSCLNPILYVLISKKFQARFRASVAEVLKRSLWEASCSGTVSEQLRSAETKSLSLLETAQ
uniprot
proteins
function
FUNCTION: Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (By similarity). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). {ECO:0000250|UniProtKB:P46091, ECO:0000250|UniProtKB:Q8K087}.
uniprot
proteins
mass_dalton
40887
uniprot
proteins
protein_family
Chemokine-like receptor (CMKLR) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
7811287
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8K087}; Multi-pass membrane protein {ECO:0000255}. Note=Internalizes in presence of its ligand, TAFA1 (By similarity). Internalizes efficiently in response to RARRES2 (By similarity). {ECO:0000250|UniProtKB:P46091, ECO:0000250|UniProtKB:Q8K087}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..62; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 74..94; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 211..231; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 248..268; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 287..307; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins