STYXL1
entrez
51657
canonical
uniprot
Q9Y6J8
canonical
ensembl
ENSG00000127952
resolver
ensp
ENSP00000248600
resolver
ensp
ENSP00000343383
resolver
ensp
ENSP00000352726
resolver
ensp
ENSP00000392221
resolver
ensp
ENSP00000554172
resolver
ensp
ENSP00000554173
resolver
ensp
ENSP00000554179
resolver
ensp
ENSP00000554182
resolver
ensp
ENSP00000599989
resolver
ensp
ENSP00000641379
resolver
genesymbol
STYXL1
resolver
genesymbol_syn
DUSP24
resolver
genesymbol_syn
MKSTYX
resolver
hgnc
HGNC:18165
resolver
uniprot
Q9UBP1
resolver
uniprot
Q9UK06
resolver
uniprot
Q9UK07
resolver
uniprot
Q9UKG2
resolver
uniprot
Q9UKG3
resolver
uniprot_entry
STYL1_HUMAN
resolver
uniprot_sec
Q9UBP1
resolver
uniprot_sec
Q9UK06
resolver
uniprot_sec
Q9UK07
resolver
uniprot_sec
Q9UKG2
resolver
uniprot_sec
Q9UKG3
resolver
amino_acid_sequence
MPGLLLCEPTELYNILNQATKLSRLTDPNYLCLLDVRSKWEYDESHVITALRVKKKNNEYLLPESVDLECVKYCVVYDNNSSTLEILLKDDDDDSDSDGDGKDLVPQAAIEYGRILTRLTHHPVYILKGGYERFSGTYHFLRTQKIIWMPQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTILGDSITNIMDPLY
uniprot
proteins
function
FUNCTION: Catalytically inactive phosphatase (PubMed:20180778, PubMed:23163895). By binding to G3BP1, inhibits the formation of G3BP1-induced stress granules (PubMed:20180778, PubMed:23163895). Does not act by protecting the dephosphorylation of G3BP1 at 'Ser-149' (PubMed:23163895). Inhibits PTPMT1 phosphatase activity (PubMed:24709986). By inhibiting PTPMT1, positively regulates intrinsic apoptosis (PubMed:21262771). May play a role in the formation of neurites during neuronal development (PubMed:29250526). {ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:21262771, ECO:0000269|PubMed:23163895, ECO:0000269|PubMed:24709986, ECO:0000269|PubMed:29250526}.
uniprot
proteins
mass_dalton
35818
uniprot
proteins
mutagenesis
MUTAGEN 245..246; /note="FS->HC: Confers phosphatase activity. Dephosphorylates G3BP1 at 'Ser-149'. Loss of interaction with G3BP1. Reduces arsenite-induced stress granule formation."; /evidence="ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23163895
uniprot
proteins
protein_family
Non-receptor class subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20180778
uniprot
proteins
pubmed
21262771
uniprot
proteins
pubmed
23163895
uniprot
proteins
pubmed
24709986
uniprot
proteins
pubmed
29250526
uniprot
proteins
pubmed
9757831
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:21262771}.
uniprot
proteins