Neu3
entrez
117185
canonical
uniprot
Q99PW5
canonical
ensembl
ENSRNOG00000018106
resolver
ensembl
ENSRNOG00055030888
resolver
ensembl
ENSRNOG00060002817
resolver
ensembl
ENSRNOG00065023750
resolver
ensp
ENSRNOP00000098329
resolver
ensp
ENSRNOP00055044316
resolver
ensp
ENSRNOP00060003229
resolver
ensp
ENSRNOP00065033157
resolver
enst
ENSRNOT00055053591
resolver
enst
ENSRNOT00060004535
resolver
enst
ENSRNOT00065040666
resolver
genesymbol
Neu3
resolver
uniprot
Q497C0
resolver
uniprot_entry
NEUR3_RAT
resolver
uniprot_sec
Q497C0
resolver
amino_acid_sequence
MEEVSSCSLRSTLFQQEEQNRITYRIPALLYIPPTHTFLAFAEMRTSSRDEDAVYLVFRRGVMKGCSVEWGPQQPLMEATLPGHRTMSPCPVWEKNTGRVYLFFICVQGHVSERWQLLWGRNAARLCFLYSEDSGCSWGEVKDLTEEVVGSEMKHWATFAVGPGHGIQLQSGRLLIPAYAYLISCWFLCFPCSVKPHSLMFYSDDLGVTWHCGKFIKPQVTGECQVAEVPGKAGNLVLYCSARTPNKFRAEAFSTDSGDCFQKPTLNQQLCEPRGGCQGSVVSTRPLKMPYTCQDSSGKDVPSTQKCPLMDRSLEVEEGAGAPSGTWLLYSHPTNKKKRMNLGIYYNQNPLEVNYWSRPWILNRGPSGYSDLAVVEGQGLFACLFECGERHEDEKIDFCLFSDQEVLSCDDCTSPSSN
uniprot
proteins
ec_number
3.2.1.18
uniprot
proteins
function
FUNCTION: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes. {ECO:0000250|UniProtKB:Q9UQ49}.
uniprot
proteins
mass_dalton
46980
uniprot
proteins
post_translational_modification
PTM: Palmitoylated; may regulate intracellular trafficking and anchorage to plasma membrane and endomembranes. {ECO:0000250|UniProtKB:Q9UQ49}.
uniprot
proteins
protein_family
Glycosyl hydrolase 33 family
uniprot
proteins
pubmed
11162581
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9UQ49}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UQ49}. Membrane, caveola {ECO:0000250|UniProtKB:Q9UQ49}. Early endosome membrane {ECO:0000250|UniProtKB:Q9UQ49}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UQ49}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9UQ49}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UQ49}. Lysosome membrane {ECO:0000250|UniProtKB:Q9UQ49}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UQ49}. Note=Associates with the external leaflet of the plasma membrane (By similarity). S-acylated NEU3 likely spans the lipid bilayer with a portion of C-terminus exposed to cytosol and the catalytic region facing the extracellular space (By similarity). {ECO:0000250|UniProtKB:Q9JMH7, ECO:0000250|UniProtKB:Q9UQ49}.
uniprot
proteins