KCNK6
entrez
9424
canonical
uniprot
Q9Y257
canonical
ensembl
ENSG00000099337
resolver
ensp
ENSP00000263372
resolver
genesymbol
KCNK6
resolver
genesymbol_syn
TOSS
resolver
genesymbol_syn
TWIK2
resolver
hgnc
HGNC:6281
resolver
uniprot
B2RDS2
resolver
uniprot
Q9HB47
resolver
uniprot_entry
B2RDS2_HUMAN
resolver
uniprot_entry
KCNK6_HUMAN
resolver
uniprot_sec
Q9HB47
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by pimozide, which blocks the selectivity filters. {ECO:0000269|PubMed:40343992}.
uniprot
proteins
amino_acid_sequence
MRRGALLAGALAAYAAYLVLGALLVARLEGPHEARLRAELETLRAQLLQRSPCVAAPALDAFVERVLAAGRLGRVVLANASGSANASDPAWDFASALFFASTLITTVGYGYTTPLTDAGKAFSIAFALLGVPTTMLLLTASAQRLSLLLTHVPLSWLSMRWGWDPRRAACWHLVALLGVVVTVCFLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTVYLFLGLVAMVLVLQTFRHVSDLHGLTELILLPPPCPASFNADEDDRVDILGPQPESHQQLSASSHTDYASIPR
uniprot
proteins
function
FUNCTION: K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system (PubMed:10887187, PubMed:28381826, PubMed:40343992, PubMed:41617707). Active in lysosomes where it regulates lysosome numbers and size (PubMed:28381826). In macrophages, enables K(+) efflux coupled to ATP-induced NLRP3 inflammasome activation upon bacterial infection. Cooperates with ATP-gated P2RX7 channels to activate NLRP3 inflammasome, with P2RX7 conducting Ca(2+) and Na(+) influx that sets the membrane potential for K(+) efflux (By similarity). {ECO:0000250|UniProtKB:Q3TBV4, ECO:0000269|PubMed:10887187, ECO:0000269|PubMed:28381826, ECO:0000269|PubMed:40343992, ECO:0000269|PubMed:41617707}.; FUNCTION: [Isoform 2]: Does not display channel activity. {ECO:0000269|PubMed:10887187}.
uniprot
proteins
mass_dalton
33747
uniprot
proteins
mutagenesis
MUTAGEN 53; /note="C->A: No channel activity."; /evidence="ECO:0000269|PubMed:10075682"; MUTAGEN 289; /note="I->A: Disrupts lysosomal targeting signal. Increases localization and K(+) current at the plasma membrane; when associated with A-290. Displays additive effects resulting in a 18-fold increase of K(+) current; when associated with A-308."; /evidence="ECO:0000269|PubMed:28381826"; MUTAGEN 290; /note="L->A: Disrupts lysosomal targeting signal. Increases localization and K(+) current at the plasma membrane; when associated with A-289. Displays additive effects resulting in a 18-fold increase of K(+) current; when associated with A-308."; /evidence="ECO:0000269|PubMed:28381826"; MUTAGEN 308; /note="Y->A: Disrupts lysosomal targeting signal. Increases localization and K(+) current at the plasma membrane. Displays additive effects resulting in a 18-fold increase of K(+) current; when associated with A-289 or A-290."; /evidence="ECO:0000269|PubMed:28381826
uniprot
proteins
post_translational_modification
PTM: N-glycosylation is necessary for targeting to lysosomes. {ECO:0000250|UniProtKB:G3V8R8}.
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
10075682
uniprot
proteins
pubmed
10359073
uniprot
proteins
pubmed
10887187
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28381826
uniprot
proteins
pubmed
40343992
uniprot
proteins
pubmed
41617707
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:28381826}; Multi-pass membrane protein {ECO:0000269|PubMed:40343992, ECO:0000269|PubMed:41617707}. Lysosome membrane {ECO:0000269|PubMed:28381826}; Multi-pass membrane protein {ECO:0000269|PubMed:40343992, ECO:0000269|PubMed:41617707}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical; Name=M1"; /evidence="ECO:0000269|PubMed:40343992, ECO:0000269|PubMed:41617707, ECO:0007744|PDB:9E94, ECO:0007744|PDB:9MEK, ECO:0007744|PDB:9MEL"; TRANSMEM 121..141; /note="Helical; Name=M2"; /evidence="ECO:0000269|PubMed:40343992, ECO:0000269|PubMed:41617707, ECO:0007744|PDB:9E94, ECO:0007744|PDB:9MEK, ECO:0007744|PDB:9MEL"; TRANSMEM 173..193; /note="Helical; Name=M3"; /evidence="ECO:0000269|PubMed:40343992, ECO:0000269|PubMed:41617707, ECO:0007744|PDB:9E94, ECO:0007744|PDB:9MEK, ECO:0007744|PDB:9MEL"; TRANSMEM 236..256; /note="Helical; Name=M4"; /evidence="ECO:0000269|PubMed:40343992, ECO:0000269|PubMed:41617707, ECO:0007744|PDB:9E94, ECO:0007744|PDB:9MEK, ECO:0007744|PDB:9MEL
uniprot
proteins