PPP3CB
entrez
5532
canonical
uniprot
P16298
canonical
ensembl
ENSG00000107758
resolver
ensp
ENSP00000343147
resolver
ensp
ENSP00000353881
resolver
ensp
ENSP00000378305
resolver
ensp
ENSP00000378306
resolver
ensp
ENSP00000556011
resolver
ensp
ENSP00000630400
resolver
genesymbol
PPP3CB
resolver
genesymbol_syn
CALNA2
resolver
genesymbol_syn
CALNB
resolver
genesymbol_syn
CNA2
resolver
hgnc
HGNC:9315
resolver
uniprot
B7Z781
resolver
uniprot
P16299
resolver
uniprot
Q5F2F9
resolver
uniprot
Q8N1F0
resolver
uniprot
Q8N3W4
resolver
uniprot_entry
B7Z781_HUMAN
resolver
uniprot_entry
PP2BB_HUMAN
resolver
uniprot_sec
P16299
resolver
uniprot_sec
Q5F2F9
resolver
uniprot_sec
Q8N1F0
resolver
uniprot_sec
Q8N3W4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)-bound calmodulin following an increase in intracellular Ca(2+) (PubMed:19154138, PubMed:25720963, PubMed:26794871). At low Ca(2+) concentrations, the catalytic subunit (also known as calcineurin A) is inactive and is bound to the regulatory subunit (also known as calcineurin B) in which only two high-affinity binding sites are occupied by Ca(2+) (PubMed:19154138, PubMed:26794871). In response to elevated calcium levels, the occupancy of the low-affinity sites on calcineurin B by Ca(2+) causes a conformational change of the C-terminal regulatory domain of calcineurin A, resulting in the exposure of the calmodulin-binding domain and in the partial activation of calcineurin A (PubMed:19154138, PubMed:26794871). The subsequent binding of Ca(2+)-bound calmodulin leads to the displacement of the autoinhibitory domain from the active site and possibly of the autoinhibitory segment from the substrate binding site which fully activates calcineurin A (PubMed:19154138, PubMed:26794871). {ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:26794871}.
uniprot
proteins
amino_acid_sequence
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGRQTLQSATVEAIEAEKAIRGFSPPHRICSFEEAKGLDRINERMPPRKDAVQQDGFNSLNTAHATENHGTGNHTAQ
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:25720963, PubMed:26794871, PubMed:32753672). Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis (PubMed:25720963, PubMed:32753672). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity). {ECO:0000250|UniProtKB:P48453, ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:32753672}.
uniprot
proteins
mass_dalton
59024
uniprot
proteins
mutagenesis
MUTAGEN 2..21; /note="Missing: Increases catalytic efficiency towards NFATC1 and DARPP32 but not towards a peptide substrate. Does not affect cytoplasmic localization and activation by calmodulin."; /evidence="ECO:0000269|PubMed:19154138"; MUTAGEN 352; /note="L->A: Severe loss of calmodulin-mediated activation. Probably prevents recognition of substrates."; /evidence="ECO:0000269|PubMed:26794871"; MUTAGEN 353; /note="P->A: Reduction of basal catalytic activity in absence of calmodulin."; /evidence="ECO:0000269|PubMed:26794871"; MUTAGEN 356; /note="M->A: Modest increase in catalytic activity in absence of calmodulin."; /evidence="ECO:0000269|PubMed:26794871"; MUTAGEN 357..524; /note="Missing: Loss of catalytic activity. Loss of interaction with PPP3R1/calreticulin B and calmodulin."; /evidence="ECO:0000269|PubMed:26794871"; MUTAGEN 361; /note="W->A: Severe reduction of basal catalytic activity in absence of calmodulin. Severe loss of calmodulin-mediated activation. Probably prevents recognition of substrates."; /evidence="ECO:0000269|PubMed:26794871"; MUTAGEN 365; /note="F->A: Moderate loss of calmodulin-mediated activation. Probably prevents recognition of substrates."; /evidence="ECO:0000269|PubMed:26794871"; MUTAGEN 398..524; /note="Missing: Increases catalytic activity independently of calmodulin. Loss of interaction with calmodulin. Does not affect interaction with PPP3R1/calreticulin B."; /evidence="ECO:0000269|PubMed:26794871"; MUTAGEN 415..524; /note="Missing: Increases catalytic activity independently of calmodulin. Does not affect interaction with PPP3R1/calreticulin B and calmodulin."; /evidence="ECO:0000269|PubMed:26794871"; MUTAGEN 417; /note="R->A: Modest increase in catalytic activity in absence of calmodulin. Does not affect interaction with calmodulin."; /evidence="ECO:0000269|PubMed:26794871"; MUTAGEN 418; /note="V->A: Does not affect catalytic activity in absence of calmodulin. Does not affect interaction with calmodulin."; /evidence="ECO:0000269|PubMed:26794871"; MUTAGEN 419; /note="F->A: Modest increase in catalytic activity in absence of calmodulin. Does not affect interaction with calmodulin."; /evidence="ECO:0000269|PubMed:26794871"; MUTAGEN 420; /note="S->A: Does not affect catalytic activity in absence of calmodulin. Does not affect interaction with calmodulin."; /evidence="ECO:0000269|PubMed:26794871"; MUTAGEN 421; /note="V->A: Modest increase in catalytic activity in absence of calmodulin. Does not affect interaction with calmodulin."; /evidence="ECO:0000269|PubMed:26794871"; MUTAGEN 422; /note="L->A: Modest increase in catalytic activity in absence of calmodulin. Does not affect interaction with calmodulin."; /evidence="ECO:0000269|PubMed:26794871"; MUTAGEN 423; /note="R->A: Modest increase in catalytic activity in absence of calmodulin. Does not affect interaction with calmodulin."; /evidence="ECO:0000269|PubMed:26794871"; MUTAGEN 451..524; /note="Missing: Increases basal catalytic activity. Does not affect interaction with PPP3R1/calreticulin B and calmodulin."; /evidence="ECO:0000269|PubMed:26794871
uniprot
proteins
protein_family
PP-2B subfamily
uniprot
proteins
protein_family
PPP phosphatase family
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1848109
uniprot
proteins
pubmed
19154138
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
2556704
uniprot
proteins
pubmed
25720963
uniprot
proteins
pubmed
26794871
uniprot
proteins
pubmed
32753672
uniprot
proteins
pubmed
34446558
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19154138}.
uniprot
proteins