SYVN1
entrez
84447
canonical
uniprot
Q86TM6
canonical
ensembl
ENSG00000162298
resolver
ensp
ENSP00000294256
resolver
ensp
ENSP00000366395
resolver
ensp
ENSP00000436984
resolver
ensp
ENSP00000574749
resolver
ensp
ENSP00000650973
resolver
ensp
ENSP00000650975
resolver
genesymbol
SYVN1
resolver
genesymbol_syn
HRD1
resolver
genesymbol_syn
KIAA1810
resolver
hgnc
HGNC:20738
resolver
uniprot
Q8N3K3
resolver
uniprot
Q8N6E8
resolver
uniprot
Q96JL5
resolver
uniprot
Q96PK3
resolver
uniprot_entry
SYVN1_HUMAN
resolver
uniprot_sec
Q8N3K3
resolver
uniprot_sec
Q8N6E8
resolver
uniprot_sec
Q96JL5
resolver
uniprot_sec
Q96PK3
resolver
amino_acid_sequence
MFRTAVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKVMGKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSPRFVALFTLLLFLKCFHWLAEDRVDFMERSPNISWLFHCRIVSLMFLLGILDFLFVSHAYHSILTRGASVQLVFGFEYAILMTMVLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIMIKVHTFPLFAIRPMYLAMRQFKKAVTDAIMSRRAIRNMNTLYPDATPEELQAMDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCRMDVLRASLPAQSPPPPEPADQGPPPAPHPPPLLPQPPNFPQGLLPPFPPGMFPLWPPMGPFPPVPPPPSSGEAVAPPSTSAAALSRPSGAATTTAAGTSATAASATASGPGSGSAPEAGPAPGFPFPPPWMGMPLPPPFAFPPMPVPPAGFAGLTPEELRALEGHERQHLEARLQSLRNIHTLLDAAMLQINQYLTVLASLGPPRPATSVNSTEETATTVVAAASSTSIPSSEATTPTPGASPPAPEMERPPAPESVGTEEMPEDGEPDAAELRRRRLQKLESPVAH
uniprot
proteins
disease_involvement
DISEASE: Note=In certain aggressive cases of activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL), plays a role in the degradation of misfolded N-terminal mutated PRDM1 proteins. {ECO:0000269|PubMed:28842558}.
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:27827840, PubMed:26471130, PubMed:28827405). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28842558). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity). During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY1, ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16289116, ECO:0000269|PubMed:16847254, ECO:0000269|PubMed:17059562, ECO:0000269|PubMed:17141218, ECO:0000269|PubMed:17170702, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:26471130, ECO:0000269|PubMed:27827840, ECO:0000269|PubMed:28827405, ECO:0000269|PubMed:28842558}.
uniprot
proteins
mass_dalton
67685
uniprot
proteins
mutagenesis
MUTAGEN 294; /note="C->A: No effect on interaction with FAM8A1, HERPUD1, OS9, SEL1L and UBE2J1."; /evidence="ECO:0000269|PubMed:28827405"; MUTAGEN 315; /note="C->S: Decreased 'Lys-48'-linked ubiquitination."; /evidence="ECO:0000269|PubMed:27827840"; MUTAGEN 329; /note="C->S: Abolishes E3 ligase activity."; /evidence="ECO:0000269|PubMed:12459480"; MUTAGEN 503; /note="R->L: Loss of interaction with FAM8A1, HERPUD1, OS9 and UBE2J1, impaired degradation of immature core-glycosylated basigin/CD147."; /evidence="ECO:0000269|PubMed:28827405
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:16289116, ECO:0000269|PubMed:16847254, ECO:0000269|PubMed:17059562, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:26471130}.
uniprot
proteins
post_translational_modification
PTM: Not N-glycosylated.; PTM: Auto-ubiquitinated. Deubiquitinated by USP19 (PubMed:27827840). {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:27827840}.
uniprot
proteins
protein_family
HRD1 family
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
12459480
uniprot
proteins
pubmed
12646171
uniprot
proteins
pubmed
12975321
uniprot
proteins
pubmed
14593114
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16186509
uniprot
proteins
pubmed
16186510
uniprot
proteins
pubmed
16289116
uniprot
proteins
pubmed
16847254
uniprot
proteins
pubmed
17059562
uniprot
proteins
pubmed
17141218
uniprot
proteins
pubmed
17170702
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18264092
uniprot
proteins
pubmed
18502753
uniprot
proteins
pubmed
18656546
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21636303
uniprot
proteins
pubmed
22607976
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26471130
uniprot
proteins
pubmed
27827840
uniprot
proteins
pubmed
28827405
uniprot
proteins
pubmed
28842558
uniprot
proteins
pubmed
30345569
uniprot
proteins
pubmed
37943610
uniprot
proteins
sequence_length
617
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:26471130}; Multi-pass membrane protein {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16186510}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 42..62; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 99..119; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins