P80225
uniprot
P80225
canonical
amino_acid_sequence
PGATLQXAXXLLVAVXAXPPPPLGVXPKPXPG
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.1.22
uniprot
proteins
ec_number
2.4.1.275
uniprot
proteins
ec_number
2.4.1.38
uniprot
proteins
ec_number
2.4.1.90
uniprot
proteins
function
FUNCTION: Galactosyltransferase acting in the Golgi stacks. Catalyzes the transfer of galactose (Gal) from UDP-alpha-D-galactose in beta(1->4) linkage to the non-reducing terminal N-acetylglucosamine (GlcNAc) moieties of glycolipids and complex-type N-linked glycans (By similarity). Adds one Gal residue to both GlcNAc beta(1->2)-linked to the alpha(1->3) and alpha(1->6) mannose antennae of complex-type N-glycans, enabling the formation of mono- and di-galactosylated glycoforms (By similarity). Galactosylates complex-type N-glycans attached on the fragment crystallizable (Fc) of immunoglobulin-gamma isotypes (IgGs), a prerequisite for antibody glycan sialylation and related anti-inflammatory effector functions (By similarity). Can also transfer a Gal residue to free GlcNAc to form N-acetyllactosamine (By similarity). With LALBA/alpha-lactalbumin forms the lactose synthase complex responsible for production of large amounts of lactose in the lactating mammary gland. Interaction with LALBA alters the sugar substrate specificity of the catalytic domain, enabling high affinity binding of glucose and its transformation to lactose (By similarity). {ECO:0000250|UniProtKB:P08037, ECO:0000250|UniProtKB:P15291}.
uniprot
proteins
mass_dalton
3137
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:P15291}.; PATHWAY: Glycolipid biosynthesis. {ECO:0000250|UniProtKB:P08037}.
uniprot
proteins
protein_family
Glycosyltransferase 7 family
uniprot
proteins
pubmed
8375379
uniprot
proteins
sequence_length
32
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P15535}; Single-pass type II membrane protein. Secreted {ECO:0000250|UniProtKB:P08037}. Cell membrane {ECO:0000250|UniProtKB:P08037}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P08037}. Cell projection, filopodium {ECO:0000250|UniProtKB:P15535}. Note=Colocalizes with MGAT3 and ST6GAL1 in the Golgi stacks of cisternae, including the cis-part of the Golgi stacks. {ECO:0000250|UniProtKB:P15291, ECO:0000250|UniProtKB:P15535}.
uniprot
proteins