Atpsckmt
entrez
499561
canonical
uniprot
D3ZLY0
canonical
ensembl
ENSRNOG00000022347
resolver
ensembl
ENSRNOG00055025459
resolver
ensembl
ENSRNOG00060023618
resolver
ensembl
ENSRNOG00065013023
resolver
ensp
ENSRNOP00000041476
resolver
ensp
ENSRNOP00055035906
resolver
ensp
ENSRNOP00060033820
resolver
ensp
ENSRNOP00065016490
resolver
enst
ENSRNOT00000046325
resolver
enst
ENSRNOT00055043923
resolver
enst
ENSRNOT00060040883
resolver
enst
ENSRNOT00065021330
resolver
genesymbol
Atpsckmt
resolver
genesymbol_syn
Fam173b
resolver
uniprot_entry
ACKMT_RAT
resolver
amino_acid_sequence
MERGETPEEERQSGCVLPTSPESDSLKTSNWGFLITGVIGGALVTVYAVTTPFIAPALRKVCLPFVPATSRQVENVVKMLQHRRGPLVDIGSGDGRIVIAAAKAGFPAVGYELNPWLVWYSRYRAWREGVHGSAKFYISDLWKVTFAQYSNVVIFGVPQMMPQLEKKLEFELEDGARVIACRFPFPHWTPDHTTGEGIDTVWAYDMSACRTQGKRA
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (Probable). Promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (By similarity). {ECO:0000250|UniProtKB:Q6P4H8, ECO:0000250|UniProtKB:Q9D1Z3, ECO:0000305|PubMed:30530489}.
uniprot
proteins
mass_dalton
24053
uniprot
proteins
protein_family
ANT/ATPSC lysine N-methyltransferase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
30530489
uniprot
proteins
sequence_length
216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250|UniProtKB:Q6P4H8}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to mitochondrial cristae. {ECO:0000250|UniProtKB:Q6P4H8}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..50; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins