AFP
entrez
174
canonical
uniprot
P02771
canonical
ensembl
ENSG00000081051
resolver
ensp
ENSP00000379138
resolver
enst
ENST00000395792
resolver
genesymbol
AFP
resolver
genesymbol_syn
HPAFP
resolver
hgnc
HGNC:317
resolver
uniprot
B2RBU3
resolver
uniprot_entry
FETA_HUMAN
resolver
uniprot_sec
B2RBU3
resolver
amino_acid_sequence
MKWVESIFLIFLLNFTESRTLHRNEYGIASILDSYQCTAEISLADLATIFFAQFVQEATYKEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKYGHSDCCSQSEEGRHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRETFMNKFIYEIARRHPFLYAPTILLWAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSLLNQHACAVMKNFGTRTFQAITVTKLSQKFTKVNFTEIQKLVLDVAHVHEHCCRGDVLDCLQDGEKIMSYICSQQDTLSNKITECCKLTTLERGQCIIHAENDEKPEGLSPNLNRFLGDRDFNQFSSGEKNIFLASFVHEYSRRHPQLAVSVILRVAKGYQELLEKCFQTENPLECQDKGEEELQKYIQESQALAKRSCGLFQKLGEYYLQNAFLVAYTKKAPQLTSSELMAITRKMAATAATCCQLSEDKLLACGEGAADIIIGHLCIRHEMTPVNPGVGQCCTSSYANRRPCFSSLVVDETYVPPAFSDDKFIFHKDLCQAQGVALQTMKQEFLINLVKQKPQITEEQLEAVIADFSGLLEKCCQGQEQEVCFAEEGQKLISKTRAALGV
uniprot
proteins
disease_involvement
DISEASE: Alpha-fetoprotein deficiency (AFPD) [MIM:615969]: A benign condition characterized by undetectable AFP levels in the amniotic fluid. Affected individuals are asymptomatic and present normal development. {ECO:0000269|PubMed:15280901, ECO:0000269|PubMed:18854864}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Alpha-fetoprotein, hereditary persistence (HPAFP) [MIM:615970]: A benign autosomal dominant condition characterized by continued expression of alpha-fetoprotein in adult life. {ECO:0000269|PubMed:7684942}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.
uniprot
proteins
mass_dalton
68678
uniprot
proteins
post_translational_modification
PTM: Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.; PTM: Sulfated. {ECO:0000269|PubMed:2414772}.
uniprot
proteins
protein_family
ALB/AFP/VDB family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15280901
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1709810
uniprot
proteins
pubmed
18854864
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2414772
uniprot
proteins
pubmed
2436661
uniprot
proteins
pubmed
2580830
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
4138095
uniprot
proteins
pubmed
6187626
uniprot
proteins
pubmed
6192439
uniprot
proteins
pubmed
70228
uniprot
proteins
pubmed
71198
uniprot
proteins
pubmed
7684942
uniprot
proteins
pubmed
80265
uniprot
proteins
pubmed
89900
uniprot
proteins
sequence_length
609
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins