Q9WV93
uniprot
Q9WV93
canonical
amino_acid_sequence
MKRAHPDYSSSDSELDETIEVEKESADENGNLSSALCSMSPTTSSQVLARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLLVRLVSHLNNYASQREAASGAHGGLGHIPWGSAFGHHPHIAHPLLLPQNGHGNAGTAASPTEPHHQGRLASAHPEAPALRAPPSGGLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFSSFHLLSPSTPTQAANLGKPYRPWGTEIGAF
uniprot
proteins
function
FUNCTION: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3. {ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:11486045, ECO:0000269|PubMed:12947105, ECO:0000269|PubMed:15107403, ECO:0000269|PubMed:15680351, ECO:0000269|PubMed:16199874, ECO:0000269|PubMed:17259303, ECO:0000269|PubMed:17303760}.
uniprot
proteins
mass_dalton
32063
uniprot
proteins
protein_family
HEY family
uniprot
proteins
pubmed
10403790
uniprot
proteins
pubmed
10415358
uniprot
proteins
pubmed
10860664
uniprot
proteins
pubmed
10964718
uniprot
proteins
pubmed
11095750
uniprot
proteins
pubmed
11160397
uniprot
proteins
pubmed
11486044
uniprot
proteins
pubmed
11486045
uniprot
proteins
pubmed
11741889
uniprot
proteins
pubmed
12947105
uniprot
proteins
pubmed
14648848
uniprot
proteins
pubmed
15107403
uniprot
proteins
pubmed
15680351
uniprot
proteins
pubmed
16199874
uniprot
proteins
pubmed
17259303
uniprot
proteins
pubmed
17303760
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11486044, ECO:0000269|PubMed:11741889}.
uniprot
proteins