Pelp1
entrez
360552
canonical
uniprot
Q56B11
canonical
ensembl
ENSRNOG00000019268
resolver
ensp
ENSRNOP00000026102
resolver
genesymbol
Pelp1
resolver
genesymbol_syn
Mnar
resolver
uniprot
Q3MIE2
resolver
uniprot_entry
PELP1_RAT
resolver
uniprot_sec
Q3MIE2
resolver
amino_acid_sequence
MAAAVLSGPTTGSPAGAPGGPGGLSAAGSGPRLRLLLLESVSGLLQPRTGSHVAPVHPPIQWAPYLPGLMCLLRLHGTAGGAQNLSALGALVNLSNAHLSSIKTRFEGLCLLSLLVGESPTELFQQHCVSWLRSIQQVLQSQDSPPTMELAVAILRDLLRYASQLPTLFRDISTNHLPGLLTSLLGLRPQCEQSALEGMKACVTYFPRACGFLKGKLASFFLSRLDSLNPQLQQLACECYSRLPSLGAGFSQGLKHTENWEQELHSLLTSLHSLLGSLFEETETAPVQSEGPGVEMLLSPSEDDNTHVLLQLWQRFSGLARCLGLMLSSEFGAPVSVPVQEILDLICRILGISSKNINLLGDGPLRLLLLPSLHLEALDLLSALILACGGRLLRFGALISRLLPQVLNTWSTGRDALAPGQERPYSTIRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLCSTRGSSDGGLQSGKPSAPKKLKLDMGEALAPPSQRKGDRNADSDVCAAALRGLSRTILMCGPLVKEETHRRLHDLVLPLVMSVQQGEVLGSSPYNSSCCRLELYRLLLALLLAPSPRCPPPLSCALKAFSLGQWEDSLEVSSFCSEALVTCSALTHPRVPPLQSSGPACPTPAPVPPPEAPSSFRAPAFHTPGPMPSIGALPSPGPVPSAGPIPTVGSMSSAGSVPSTGPVPSRPGPPATANHLGLAVPGLVSVPPRLLPGSENHRAGSGEDPVLAPSGTPPPSIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPSLPPPPSGTPPPVAPIGPPTASPPVPAKEDSEELPATPGPLPPPPPPPPPVSGPVTLPPPQLVPEGTPGGGGPTAMEEDLTVININSSDEEEEEEEEEEEEDEDVEEEDFEEEEEDEEEYFEEEEEEEEFEEEFEEEEGELEEEEEEEEEELEEVEDVEFGSAGEVEEGGPPPPTLPPALPPTDSPKVQPEAEPEPGLLLEVEEPGAEDGPGPEIAPTLAPEVLPSQEEVEREGESPTAGPPQELVEEESSAPPTLLEEGTEGGGDKVPPPPETPAQEEMETETEASAPQGKEQDDTAAMLADFIDCPPDDEKPPPATEPDS
uniprot
proteins
function
FUNCTION: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1. {ECO:0000250|UniProtKB:Q8IZL8}.
uniprot
proteins
mass_dalton
119139
uniprot
proteins
post_translational_modification
PTM: Transiently sumoylated, preferentially conjugated to SUMO2 or SUMO3. Sumoylation causes nucleolar exclusion of PELP1 and promotes the recruitment of MDN1 to pre-60S particles. Desumoylation by SUMO isopeptidase SENP3 is needed to release both PELP1 and MDN1 from pre-ribosomes. {ECO:0000250|UniProtKB:Q8IZL8}.
uniprot
proteins
protein_family
RIX1/PELP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141397
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8IZL8}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q8IZL8}. Nucleus {ECO:0000269|PubMed:16141397}. Cytoplasm {ECO:0000269|PubMed:16141397}. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasm. Also found associated with the plasma membrane. {ECO:0000250|UniProtKB:Q8IZL8}.
uniprot
proteins