Or4e2
entrez
57271
canonical
uniprot
Q7TQQ0
canonical
ensembl
ENSMUSG00000035626
resolver
ensp
ENSMUSP00000046688
resolver
ensp
ENSMUSP00000145819
resolver
ensp
ENSMUSP00000146173
resolver
ensp
ENSMUSP00000150016
resolver
enst
ENSMUST00000045066
resolver
enst
ENSMUST00000205900
resolver
enst
ENSMUST00000206100
resolver
enst
ENSMUST00000215030
resolver
genesymbol
Or4e2
resolver
genesymbol_syn
MOR244-3
resolver
genesymbol_syn
MOR83
resolver
genesymbol_syn
Olfr1509
resolver
uniprot
A0A0U1RP41
resolver
uniprot
Q9R0K3
resolver
uniprot_entry
OR4E2_MOUSE
resolver
uniprot_sec
A0A0U1RP41
resolver
uniprot_sec
Q9R0K3
resolver
activity_regulation
ACTIVITY REGULATION: Copper binding enhances receptor activity in response to odorant binding. {ECO:0000269|PubMed:22328155, ECO:0000269|PubMed:25185561, ECO:0000269|PubMed:29659735}.
uniprot
proteins
amino_acid_sequence
MGALNQTRVTEFIFLGLTDNWVLEILFFVPFTVTYMLTLLGNFLIVVTIVFTPRLHNPMYFFLSNLSFIDICHSSVTVPKMLEGLLLERKTISFDNCIAQLFFLHLFACSEIFLLTIMAYDRYVAICIPLHYSNVMNMKVCVQLVFALWLGGTIHSLVQTFLTIRLPYCGPNIIDSYFCDVPPVIKLACTDTYLTGILIVSNSGTISLVCFLALVTSYTVILFSLRKQSAEGRRKALSTCSAHFMVVALFFGPCIFLYTRPDSSFSIDKVVSVFYTVVTPLLNPLIYTLRNEEVKTAMKHLRQRRICS
uniprot
proteins
function
FUNCTION: Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanethiol (MTMT) and bis(methylthiomethyl) disulfide (PubMed:22328155, PubMed:25185561, PubMed:25901328, PubMed:29659735). Also binds odorants cis-cyclooctene and tert-butyl mercaptan (PubMed:27019154). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Potential). {ECO:0000269|PubMed:22328155, ECO:0000269|PubMed:25185561, ECO:0000269|PubMed:25901328, ECO:0000269|PubMed:27019154, ECO:0000269|PubMed:29659735, ECO:0000305}.
uniprot
proteins
mass_dalton
34986
uniprot
proteins
mutagenesis
MUTAGEN 56; /note="H->K: Decreased receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 59; /note="M->A: Decreased receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 73; /note="H->A,K,R: No receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 73; /note="H->F,Y: No change in receptor activity in response to MTMT binding. No change in the copper-induced enhancement of receptor activity."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 97; /note="C->A,V: No receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 97; /note="C->S: No receptor activity in response to MTMT binding, even in the presence of copper. Little to no expression detected on plasma membrane."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 105; /note="H->A,L,R: No receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 105; /note="H->K: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 109; /note="C->M: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Shows low constitutive activity in the presence of copper. MTMT binding in the absence of copper results in an inverse agonist effect."; /evidence="ECO:0000269|PubMed:25185561"; MUTAGEN 109; /note="C->V: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper."; /evidence="ECO:0000269|PubMed:22328155, ECO:0000269|PubMed:25185561"; MUTAGEN 118; /note="M->A: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 127; /note="C->V: Decreased receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 136; /note="M->A: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 141; /note="C->V: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 155; /note="H->A,K,N,V: No receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 155; /note="H->R: No receptor activity in response to MTMT binding, even in the presence of copper. Little to no expression detected on plasma membrane."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 169; /note="C->A,F,V: No receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 169; /note="C->S: No receptor activity in response to MTMT binding, even in the presence of copper. Little to no expression detected on plasma membrane."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 179; /note="C->A,V: No receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 179; /note="C->S: No receptor activity in response to MTMT binding, even in the presence of copper. Little to no expression detected on plasma membrane."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 189; /note="C->A,V: No receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 189; /note="C->S: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 210; /note="C->A: No change in receptor activity in response to MTMT binding in the presence of copper. Decreased receptor activity in the absence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 210; /note="C->S: No change in receptor activity in response to MTMT binding in the presence of copper. Complete loss of receptor activity in the absence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 210; /note="C->V: No receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 243; /note="H->A,K: No receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 243; /note="H->R: No receptor activity in response to MTMT binding, even in the presence of copper. Little to no expression detected on plasma membrane."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 254; /note="C->V,S: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper."; /evidence="ECO:0000269|PubMed:22328155, ECO:0000269|PubMed:29659735"; MUTAGEN 260; /note="R->H: Decreased receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:29659735"; MUTAGEN 260; /note="R->W,A: No receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:29659735"; MUTAGEN 269; /note="K->A: Decreased receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:29659735"; MUTAGEN 269; /note="K->H: No receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:29659735"; MUTAGEN 298; /note="M->A: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 300; /note="H->K: Decreased receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:22328155"; MUTAGEN 307; /note="C->V: Decreased receptor activity in response to MTMT binding, even in the presence of copper."; /evidence="ECO:0000269|PubMed:22328155
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10493742
uniprot
proteins
pubmed
11875048
uniprot
proteins
pubmed
14611657
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18214836
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22328155
uniprot
proteins
pubmed
25185561
uniprot
proteins
pubmed
25901328
uniprot
proteins
pubmed
27019154
uniprot
proteins
pubmed
29659735
uniprot
proteins
sequence_length
308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255, ECO:0000255|RuleBase:RU363047, ECO:0000269|PubMed:22328155, ECO:0000269|PubMed:27019154, ECO:0000269|PubMed:29659735, ECO:0000305|PubMed:25185561, ECO:0000305|PubMed:25901328}; Multi-pass membrane protein {ECO:0000255, ECO:0000255|RuleBase:RU363047, ECO:0000269|PubMed:27019154}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 58..78; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 98..118; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 205..225; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 237..257; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins