Nr1h2
entrez
22260
canonical
uniprot
Q60644
canonical
ensembl
ENSMUSG00000060601
resolver
ensp
ENSMUSP00000073188
resolver
ensp
ENSMUSP00000103543
resolver
ensp
ENSMUSP00000103544
resolver
ensp
ENSMUSP00000103545
resolver
ensp
ENSMUSP00000126788
resolver
ensp
ENSMUSP00000296424
resolver
enst
ENSMUST00000073488
resolver
enst
ENSMUST00000107910
resolver
enst
ENSMUST00000107911
resolver
enst
ENSMUST00000107912
resolver
enst
ENSMUST00000167197
resolver
genesymbol
Nr1h2
resolver
genesymbol_syn
Lxrb
resolver
genesymbol_syn
Rip15
resolver
genesymbol_syn
Unr
resolver
genesymbol_syn
Unr2
resolver
uniprot
F6THB2
resolver
uniprot
Q8BP65
resolver
uniprot_entry
F6THB2_MOUSE
resolver
uniprot_entry
NR1H2_MOUSE
resolver
uniprot_entry
Q8BP65_MOUSE
resolver
amino_acid_sequence
MSSPTSSLDTPVPGNGSPQPSTSATSPTIKEEGQETDPPPGSEGSSSAYIVVILEPEDEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCKEAGMREQCVLSEEQIRKKRIQKQQQQQPPPPSEPAASSSGRPAASPGTSEASSQGSGEGEGIQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
uniprot
proteins
function
FUNCTION: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4) (PubMed:18055760, PubMed:19520913, PubMed:20427281). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8 (PubMed:18055760, PubMed:19520913, PubMed:20427281). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (PubMed:18055760, PubMed:19520913, PubMed:20427281, PubMed:24206663, PubMed:28846071). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (PubMed:25806685, PubMed:28846071). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (PubMed:25806685). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (PubMed:24206663). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity). {ECO:0000250|UniProtKB:P55055, ECO:0000269|PubMed:18055760, ECO:0000269|PubMed:19520913, ECO:0000269|PubMed:20427281, ECO:0000269|PubMed:24206663, ECO:0000269|PubMed:25806685, ECO:0000269|PubMed:28846071}.
uniprot
proteins
mass_dalton
49720
uniprot
proteins
post_translational_modification
PTM: Sumoylated by SUMO2 at Lys-395 and Lys-433 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation. {ECO:0000250|UniProtKB:P55055}.
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10675617
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18055760
uniprot
proteins
pubmed
19520913
uniprot
proteins
pubmed
20427281
uniprot
proteins
pubmed
24206663
uniprot
proteins
pubmed
25806685
uniprot
proteins
pubmed
28846071
uniprot
proteins
pubmed
7760852
uniprot
proteins
sequence_length
446
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
uniprot
proteins