Nthl1
entrez
18207
canonical
uniprot
O35980
canonical
ensembl
ENSMUSG00000041429
resolver
ensp
ENSMUSP00000047413
resolver
enst
ENSMUST00000047611
resolver
genesymbol
Nthl1
resolver
genesymbol_syn
Nth1
resolver
uniprot
E9QMW1
resolver
uniprot_entry
NTH_MOUSE
resolver
uniprot_sec
E9QMW1
resolver
amino_acid_sequence
MNSGVRMVTRSRSRATRIASEGCREELAPREAAAEGRKSHRPVRHPRRTQKTHVAYEAANGEEGEDAEPLKVPVWEPQNWQQQLANIRIMRSKKDAPVDQLGAEHCYDASASPKVRRYQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVESILQTDDDTLGRLIYPVGFWRNKVKYIKQTTAILQQRYEGDIPASVAELVALPGVGPKMAHLAMAVAWGTISGIAVDTHVHRIANRLRWTKKMTKTPEETRKNLEEWLPRVLWSEVNGLLVGFGQQICLPVHPRCQACLNKALCPAAQDL
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
ec_number
4.2.99.18
uniprot
proteins
function
FUNCTION: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:9743625}.
uniprot
proteins
mass_dalton
33637
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by TRIM26; leading to proteasomal degradation. {ECO:0000250|UniProtKB:P78549}.
uniprot
proteins
protein_family
Nth/MutY family
uniprot
proteins
pubmed
12531031
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9743625
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03183}. Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:12531031}.
uniprot
proteins