Sdc4
entrez
24771
canonical
uniprot
P34901
canonical
ensembl
ENSRNOG00000014297
resolver
ensembl
ENSRNOG00055004177
resolver
ensembl
ENSRNOG00060001202
resolver
ensembl
ENSRNOG00065026184
resolver
ensp
ENSRNOP00000019386
resolver
ensp
ENSRNOP00055005109
resolver
ensp
ENSRNOP00060000920
resolver
ensp
ENSRNOP00065037041
resolver
enst
ENSRNOT00000019386
resolver
enst
ENSRNOT00055006674
resolver
enst
ENSRNOT00060001705
resolver
enst
ENSRNOT00065045161
resolver
genesymbol
Sdc4
resolver
genesymbol_syn
Synd4
resolver
uniprot_entry
SDC4_RAT
resolver
amino_acid_sequence
MAPVCLFAPLLLLLLGGFPVAPGESIRETEVIDPQDLLEGRYFSGALPDDEDAGGLEQDSDFELSGSGDLDDTEEPRTFPEVISPLVPLDNHIPENAQPGIRVPSEPKELEENEVIPKRVPSDVGDDDVSNKVSMSSTSQGSNIFERTEVLAALIVGGVVGILFAVFLILLLVYRMKKKDEGSYDLGKKPIYKKAPTNEFYA
uniprot
proteins
function
FUNCTION: Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP. {ECO:0000250|UniProtKB:P31431}.
uniprot
proteins
mass_dalton
21962
uniprot
proteins
mutagenesis
MUTAGEN 44; /note="S->T: Reduced glycosaminoglycan attachment."; /evidence="ECO:0000269|PubMed:7520439"; MUTAGEN 65; /note="S->T: Reduced glycosaminoglycan attachment."; /evidence="ECO:0000269|PubMed:7520439"; MUTAGEN 67; /note="S->T: Reduced glycosaminoglycan attachment."; /evidence="ECO:0000269|PubMed:7520439
uniprot
proteins
post_translational_modification
PTM: Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3 (By similarity). {ECO:0000250|UniProtKB:P31431}.; PTM: O-glycosylated; contains both chondroitin sulfate and heparan sulfate (PubMed:7520439). Ser-44, Ser-65 and Ser-67 can all be modified by either chondroitin sulfate or heparan sulfate, and the protein exists in forms that contain only chondroitin sulfate, only heparan sulfate and both chondroitin sulfate and heparan sulfate (PubMed:7520439). {ECO:0000269|PubMed:7520439}.
uniprot
proteins
protein_family
Syndecan proteoglycan family
uniprot
proteins
pubmed
1537865
uniprot
proteins
pubmed
7520439
uniprot
proteins
pubmed
8495865
uniprot
proteins
sequence_length
202
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:P31431}. Note=Shedding of the ectodomain produces a soluble form. {ECO:0000250|UniProtKB:P31431}.
uniprot
proteins
transmembrane_region
TRANSMEM 150..174; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins