Gosr1
entrez
53334
canonical
uniprot
O88630
canonical
ensembl
ENSMUSG00000010392
resolver
ensp
ENSMUSP00000010536
resolver
ensp
ENSMUSP00000314263
resolver
enst
ENSMUST00000010536
resolver
genesymbol
Gosr1
resolver
genesymbol_syn
Gs28
resolver
uniprot
Q91VU9
resolver
uniprot_entry
GOSR1_MOUSE
resolver
uniprot_sec
Q91VU9
resolver
amino_acid_sequence
MAAGTSNYWEDLRKQARQLENELDLKLVSFSKLCTSYSHSGSRDGGRDRYSSDTTPLLNGSSQDRMFETMAIEIEQLLARLTGVNDKMAEYTHSAGVPSLNAALMHTLQRHRDILQDYTHEFHKTKANFTAIRERENLMGSVRKDIESYKSGSGVNNRRTELFLKEHDHLRNSDRLIEETISIAMATKENMTSQRGMLKSIHSKMNTLANRFPAVNSLIQRINLRKRRDSLILGGVIGICTILLLLYAFH
uniprot
proteins
function
FUNCTION: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
28489
uniprot
proteins
protein_family
GOSR1 family
uniprot
proteins
pubmed
15250942
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15250942}; Single-pass type IV membrane protein {ECO:0000269|PubMed:15250942}. Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network. Enriched on vesicular components at the terminal rims of the Golgi. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 230..250; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins