LTA
entrez
4049
canonical
uniprot
P01374
canonical
ensembl
ENSG00000173503
resolver
ensembl
ENSG00000223919
resolver
ensembl
ENSG00000226275
resolver
ensembl
ENSG00000226979
resolver
ensembl
ENSG00000230279
resolver
ensembl
ENSG00000231408
resolver
ensembl
ENSG00000238130
resolver
ensp
ENSP00000372791
resolver
ensp
ENSP00000372793
resolver
ensp
ENSP00000372991
resolver
ensp
ENSP00000383131
resolver
ensp
ENSP00000387924
resolver
ensp
ENSP00000395895
resolver
ensp
ENSP00000395976
resolver
ensp
ENSP00000402413
resolver
ensp
ENSP00000403495
resolver
ensp
ENSP00000407133
resolver
ensp
ENSP00000412555
resolver
ensp
ENSP00000413450
resolver
ensp
ENSP00000416337
resolver
ensp
ENSP00000416509
resolver
ensp
ENSP00000547386
resolver
enst
ENST00000383303
resolver
enst
ENST00000383304
resolver
enst
ENST00000383499
resolver
enst
ENST00000400272
resolver
enst
ENST00000412851
resolver
enst
ENST00000418386
resolver
enst
ENST00000426845
resolver
enst
ENST00000432632
resolver
enst
ENST00000436519
resolver
enst
ENST00000441939
resolver
enst
ENST00000448630
resolver
enst
ENST00000454550
resolver
enst
ENST00000454783
resolver
enst
ENST00000456789
resolver
enst
ENST00000877327
resolver
genesymbol
LTA
resolver
genesymbol
TNLG1E
resolver
genesymbol_syn
LTA
resolver
genesymbol_syn
TNFB
resolver
genesymbol_syn
TNFSF1
resolver
hgnc
HGNC:6709
resolver
uniprot
A0A0G2JHD4
resolver
uniprot
Q5HYS4
resolver
uniprot
Q5ST95
resolver
uniprot
Q5STV3
resolver
uniprot
Q6FG55
resolver
uniprot
Q8N4C3
resolver
uniprot
Q9UKS8
resolver
uniprot_entry
A0A0G2JHD4_HUMAN
resolver
uniprot_entry
Q5ST95_HUMAN
resolver
uniprot_entry
Q5STV3_HUMAN
resolver
uniprot_entry
Q6FG55_HUMAN
resolver
uniprot_entry
TNFB_HUMAN
resolver
uniprot_sec
Q5HYS4
resolver
uniprot_sec
Q8N4C3
resolver
uniprot_sec
Q9UKS8
resolver
amino_acid_sequence
MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL
uniprot
proteins
disease_involvement
DISEASE: Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). {ECO:0000269|PubMed:12746914}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed:9462508). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR (PubMed:24248355). Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. {ECO:0000269|PubMed:24248355, ECO:0000269|PubMed:9462508}.
uniprot
proteins
mass_dalton
22297
uniprot
proteins
mutagenesis
MUTAGEN 142; /note="Y->A: Reduces binding of LTA(1)-LTB(2) to LTBR and LTBR-mediated NF-kappa-B signaling activation. Reduces binding of LTA(1)-LTB(2) to LTBR and abolishes LTBR-mediated NF-kappa-B signaling activation; when associated with 'E-108'; 'R-109' and 'E-142' in LTB (subunit 1). Abolishes binding of LTA(1)-LTB(2) to LTBR and abolishes LTBR-mediated NF-kappa-B signaling activation; when associated with 'E-108'; 'R-109'; 'E-142' and 'A-170' in LTB (subunit 1), and 'E-108'; 'R-109' and 'E-142' in LTB (subunit 2)."; /evidence="ECO:0000269|PubMed:24248355
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
10202016
uniprot
proteins
pubmed
12746914
uniprot
proteins
pubmed
1353024
uniprot
proteins
pubmed
1451807
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1670638
uniprot
proteins
pubmed
1671667
uniprot
proteins
pubmed
1733919
uniprot
proteins
pubmed
17353895
uniprot
proteins
pubmed
24248355
uniprot
proteins
pubmed
3001109
uniprot
proteins
pubmed
3536896
uniprot
proteins
pubmed
3555974
uniprot
proteins
pubmed
6334807
uniprot
proteins
pubmed
8387891
uniprot
proteins
pubmed
8499947
uniprot
proteins
pubmed
9462508
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated.
uniprot
proteins