Enah
entrez
13800
canonical
uniprot
Q03173
canonical
ensembl
ENSMUSG00000022995
resolver
ensp
ENSMUSP00000077781
resolver
ensp
ENSMUSP00000106653
resolver
ensp
ENSMUSP00000106659
resolver
ensp
ENSMUSP00000141344
resolver
ensp
ENSMUSP00000141462
resolver
ensp
ENSMUSP00000176743
resolver
enst
ENSMUST00000078719
resolver
enst
ENSMUST00000111024
resolver
enst
ENSMUST00000111030
resolver
enst
ENSMUST00000195059
resolver
genesymbol
Enah
resolver
genesymbol_syn
Mena
resolver
genesymbol_syn
Ndpp1
resolver
uniprot
A0A0A6YW06
resolver
uniprot
E9QKQ9
resolver
uniprot
E9QKR1
resolver
uniprot
E9QLZ9
resolver
uniprot
P70430
resolver
uniprot
P70431
resolver
uniprot
P70432
resolver
uniprot
P70433
resolver
uniprot
Q5D053
resolver
uniprot_entry
A0A0A6YW06_MOUSE
resolver
uniprot_entry
E9QKQ9_MOUSE
resolver
uniprot_entry
E9QKR1_MOUSE
resolver
uniprot_entry
E9QLZ9_MOUSE
resolver
uniprot_entry
ENAH_MOUSE
resolver
uniprot_sec
P70430
resolver
uniprot_sec
P70431
resolver
uniprot_sec
P70432
resolver
uniprot_sec
P70433
resolver
uniprot_sec
Q5D053
resolver
amino_acid_sequence
MSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANVFASAMMHALEVLNSQEAAQSKVTATQDSTNLRCIFCGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERMERERLERERLERERLERERLEQEQLERQRQEREHVERLERERLERLERERQERERERLEQLEREQVEWERERRMSNAAPSSDSSLSSAPLPEYSSCQPPSAPPPSYAKVISAPVSDATPDYAVVTALPPTSTPPTPPLRHAATRFATSLGSAFHPVLPHYATVPRPLNKNSRPSSPVNTPSSQPPAAKSCAWPTSNFSPLPPSPPIMISSPPGKATGPRPVLPVCVSSPVPQMPPSPTAPNGSLDSVTYPVSPPPTSGPAAPPPPPPPPPPPPPPPLPPPPLPPLASLSHCGSQASPPPGTPLASTPSSKPSVLPSPSAGAPASAETPLNPELGDSSASEPGLQAASQPAESPTPQGLVLGPPAPPPPPPLPSGPAYASALPPPPGPPPPPPLPSTGPPPPPPPPPPLPNQAPPPPPPPPAPPLPASGIFSGSTSEDNRPLTGLAAAIAGAKLRKVSRVEDGSFPGGGNTGSVSLASSKADAGRGNGPLPLGGSGLMEEMSALLARRRRIAEKGSTIETEQKEDRNEDAEPITAKAPSTSTPEPTRKPWERTNTMNGSKSPVISRPKSTPSSQPSANGVQTEGLDYDRLKQDILDEMRKELAKLKEELIDAIRQELSKSNTA
uniprot
proteins
function
FUNCTION: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation. {ECO:0000269|PubMed:10069337, ECO:0000269|PubMed:12134088, ECO:0000269|PubMed:15066263, ECO:0000269|PubMed:8861907}.
uniprot
proteins
mass_dalton
85844
uniprot
proteins
mutagenesis
MUTAGEN 255; /note="S->A: No change in subcellular location nor colocalization with vinculin at focal adhesions nor with N-WASP at the leading edge. Loss of cell mobility function; when associated with A-637."; /evidence="ECO:0000269|PubMed:12134088"; MUTAGEN 255; /note="S->D: No change in subcellular location nor colocalization with vinculin at focal adhesions nor with N-WASP at the leading edge. No loss of cell mobility function; when associated with D-637."; /evidence="ECO:0000269|PubMed:12134088"; MUTAGEN 637; /note="S->A: No change in subcellular location nor colocalization with vinculin at focal adhesions nor with N-WASP at the leading edge. No loss of cell mobility function. when associated with A-255."; /evidence="ECO:0000269|PubMed:12134088"; MUTAGEN 637; /note="S->D: No change in subcellular location nor colocalization with vinculin at focal adhesions nor with N-WASP at the leading edge. No loss of cell mobility function. when associated with D-255."; /evidence="ECO:0000269|PubMed:12134088
uniprot
proteins
post_translational_modification
PTM: NTN1-induced PKA phosphorylation on Ser-255 directly parallels the formation of filopodial protrusions. {ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15066263}.
uniprot
proteins
protein_family
Ena/VASP family
uniprot
proteins
pubmed
10069337
uniprot
proteins
pubmed
10338211
uniprot
proteins
pubmed
12134088
uniprot
proteins
pubmed
12672821
uniprot
proteins
pubmed
12941633
uniprot
proteins
pubmed
1420303
uniprot
proteins
pubmed
14506234
uniprot
proteins
pubmed
15066263
uniprot
proteins
pubmed
15148305
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15642358
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24332715
uniprot
proteins
pubmed
8861907
uniprot
proteins
pubmed
9171351
uniprot
proteins
pubmed
9407065
uniprot
proteins
sequence_length
802
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10069337, ECO:0000269|PubMed:12134088, ECO:0000269|PubMed:8861907}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Synapse {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Targeted to the leading edge of lamellipodia and filopodia by MRL family members. Colocalizes at filopodial tips with a number of other proteins including vinculin and zyxlin. Colocalizes with N-WASP at the leading edge. Colocalizes with GPHN and PFN at synapses (By similarity). {ECO:0000250}.
uniprot
proteins