Fcgr2
entrez
14130
canonical
uniprot
P08101
canonical
ensembl
ENSMUSG00000026656
resolver
ensp
ENSMUSP00000027966
resolver
ensp
ENSMUSP00000079882
resolver
ensp
ENSMUSP00000123774
resolver
ensp
ENSMUSP00000137669
resolver
ensp
ENSMUSP00000302682
resolver
ensp
ENSMUSP00000302683
resolver
ensp
ENSMUSP00000329915
resolver
enst
ENSMUST00000027966
resolver
enst
ENSMUST00000081103
resolver
enst
ENSMUST00000159688
resolver
enst
ENSMUST00000159969
resolver
genesymbol
Fcgr2
resolver
genesymbol
Fcgr2b
resolver
genesymbol_syn
Fcgr2b
resolver
genesymbol_syn
Ly-17
resolver
uniprot
A0A0B4J1E6
resolver
uniprot
A0A0B4J1G1
resolver
uniprot
E9Q415
resolver
uniprot
P08102
resolver
uniprot
P12316
resolver
uniprot
P97917
resolver
uniprot
Q60938
resolver
uniprot
Q60939
resolver
uniprot
Q60940
resolver
uniprot
Q61170
resolver
uniprot
Q61558
resolver
uniprot_entry
A0A0B4J1E6_MOUSE
resolver
uniprot_entry
A0A0B4J1G1_MOUSE
resolver
uniprot_entry
E9Q415_MOUSE
resolver
uniprot_entry
FCGR2_MOUSE
resolver
uniprot_sec
P08102
resolver
uniprot_sec
P12316
resolver
uniprot_sec
P97917
resolver
uniprot_sec
Q60938
resolver
uniprot_sec
Q60939
resolver
uniprot_sec
Q60940
resolver
uniprot_sec
Q61170
resolver
uniprot_sec
Q61558
resolver
amino_acid_sequence
MESNWTVHVFSRTLCHMLLWTAVLNLAAGTHDLPKAVVKLEPPWIQVLKEDTVTLTCEGTHNPGNSSTQWFHNGRSIRSQVQASYTFKATVNDSGEYRCQMEQTRLSDPVDLGVISDWLLLQTPQLVFLEGETITLRCHSWRNKLLNRISFFHNEKSVRYHHYSSNFSIPKANHSHSGDYYCKGSLGRTLHQSKPVTITVQGPKSSRSLPVLTIVAAVTGIAVAAIVIILVSLVYLKKKQVPALPGNPDHREMGETLPEEVGEYRQPSGGSVPVSPGPPSGLEPTSSSPYNPPDLEEAAKTEAENTITYSLLKHPEALDEETEHDYQNHI
uniprot
proteins
function
FUNCTION: Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis. Isoform IIB2 can mediate the endocytosis of soluble immune complexes via clathrin-coated pits. Isoform IIB1 and isoform IIB2 can down-regulate B-cell, T-cell, and mast cell activation when coaggregated to B-cell receptors for AG (BCR), T-cell receptors for AG (TCR), and Fc receptors, respectively.
uniprot
proteins
mass_dalton
36695
uniprot
proteins
post_translational_modification
PTM: Glycosylated.; PTM: When coaggregated to BCR, isoform IIB1 and isoform IIB1' become tyrosine phosphorylated and bind to the SH2 domains of the protein tyrosine phosphatase PTPC1. Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
11035084
uniprot
proteins
pubmed
1824594
uniprot
proteins
pubmed
2138587
uniprot
proteins
pubmed
2944118
uniprot
proteins
pubmed
2946078
uniprot
proteins
pubmed
2957319
uniprot
proteins
pubmed
3024012
uniprot
proteins
pubmed
8398981
uniprot
proteins
pubmed
8537115
uniprot
proteins
pubmed
8683114
uniprot
proteins
pubmed
9469421
uniprot
proteins
sequence_length
330
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform IIB1]: Cytoplasm, cytoskeleton. Note=Binds the cytoskeleton and is not localized in endocytotic pits.; SUBCELLULAR LOCATION: [Isoform IIB3]: Secreted. Note=Released as a soluble molecule.
uniprot
proteins
transmembrane_region
TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins