C2cd2l
entrez
71764
canonical
uniprot
Q80X80
canonical
ensembl
ENSMUSG00000032120
resolver
ensp
ENSMUSP00000065233
resolver
ensp
ENSMUSP00000149180
resolver
ensp
ENSMUSP00000186810
resolver
enst
ENSMUST00000065080
resolver
enst
ENSMUST00000214602
resolver
genesymbol
C2cd2l
resolver
genesymbol_syn
Tmem24
resolver
uniprot
A0A1L1SQT4
resolver
uniprot
G5E8D9
resolver
uniprot
Q3U590
resolver
uniprot
Q8CAA2
resolver
uniprot
Q9DBJ2
resolver
uniprot_entry
A0A1L1SQT4_MOUSE
resolver
uniprot_entry
C2C2L_MOUSE
resolver
uniprot_entry
Q3U590_MOUSE
resolver
uniprot_entry
Q8CAA2_MOUSE
resolver
uniprot_entry
Q9DBJ2_MOUSE
resolver
uniprot_sec
G5E8D9
resolver
amino_acid_sequence
MDPDWGQRDVGWAALLVLFAASLITVLGWMLQYARGLWLSRADGGRDSRPASAAEPGGSLRELGVWRSLLRLRATRTSTPEEAGVRGLLASLFAFKSFRENWQRAWVRALNEQACRDGSSIQIAFEEIPQLPPRASISHVTCVDQSERTMVLHCQLSAEEVRFPISVTQQSPAAVSMETYHVTLTLPPTQLEVSLEEIPDEGLLVSWAFTDRPELSLKVLPKLQTRERDEEQPELSTVEELIKDAIVSTQPAMMVNLRACSAPGGLVPSEKPPTMSQAQPSIPRPTRLFLRQLRASHLGSELGGTEELCCAAELDNPMQQKWTKPMRAGPEVEWTEDLALDLGPQSRELTLKVLRSSSCGDAELLGQATLPVGSPSRPMSRRQVCPLTPGPGKSLSPAATVTAELHYEQGSPRNLGTPTSSTPRPSITPTKKIELDRTIMPDGTVVTTVTTVQSRPRVDGKLDSPSRSPSKVEVTEKMTTVLSESSGPSNASHSSSRESHLSNGLDPVAETAIRQLTEPSGRAAKKTPTKRSTLIISGVSKVPIAQDELALSLGYAASLEASMQDDAGTSGGPSSPPSDPSATSPGPVDALSSPTSVQEADETTRSDISERPSVDDVESETGSTGALETRSLKDHKVSFLRSGTKLIFRRRPRQKEAGLSQSHDDLSNTTATPSVRKKAGSFSRRLIKRFSFKSKPKANGNPSPQL
uniprot
proteins
function
FUNCTION: Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (By similarity). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (By similarity). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (By similarity). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (By similarity). Positively regulates insulin secretion in response to glucose (PubMed:24012759). Phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (By similarity). {ECO:0000250|UniProtKB:O14523, ECO:0000269|PubMed:24012759}.
uniprot
proteins
mass_dalton
76329
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at the C-terminus acidifies the protein and leads to disassociation from the acidic cell membrane. Reassociates with the cell membrane upon dephosphorylation. {ECO:0000250|UniProtKB:O14523}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24012759
uniprot
proteins
sequence_length
706
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O14523}; Single-pass membrane protein {ECO:0000250|UniProtKB:O14523}. Cell membrane {ECO:0000250|UniProtKB:O14523}; Peripheral membrane protein {ECO:0000250|UniProtKB:O14523}. Note=Localizes to sites of contact between the endoplasmic reticulum and the cell membrane. Embedded into the endoplasmic reticulum membrane via its N-terminal transmembrane domain and associates with cell membrane via its C-terminus. In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane and localizes to the reticular endoplasmic reticulum. Reassociates with cell membrane upon dephosphorylation. {ECO:0000250|UniProtKB:O14523}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins