Q6T3U4
uniprot
Q6T3U4
canonical
amino_acid_sequence
MAAAWQGWLLWALLLNSAQGELYTPTHKAGFCTFYEECGKNPELSGGLTSLSNISCLSNTPARHVTGDHLALLQRVCPRLYNGPNDTYACCSTKQLVSLDSSLSITKALLTRCPACSENFVSIHCHNTCSPDQSLFINVTRVVQRDPGQLPAVVAYEAFYQRSFAEKAYESCSRVRIPAAASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALADGMKPLDGKITPCNESQGEDSAACSCQDCAASCPVIPPPPALRPSFYMGRMPGWLALIIIFTAVFVLLSVVLVYLRVASNRNKNKTAGSQEAPNLPRKRRFSPHTVLGRFFESWGTRVASWPLTVLALSFIVVIALSVGLTFIELTTDPVELWSAPKSQARKEKAFHDEHFGPFFRTNQIFVTAKNRSSYKYDSLLLGPKNFSGILSLDLLQELLELQERLRHLQVWSHEAQRNISLQDICYAPLNPHNTSLTDCCVNSLLQYFQNNHTLLLLTANQTLNGQTSLVDWKDHFLYCANAPLTYKDGTALALSCIADYGAPVFPFLAVGGYQGTDYSEAEALIITFSINNYPADDPRMAHAKLWEEAFLKEMQSFQRSTADKFQIAFSAERSLEDEINRTTIQDLPVFAISYLIVFLYISLALGSYSRWSRVAVDSKATLGLGGVAVVLGAVVAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPGEQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTSMPAVRTFALTSGLAIIFDFLLQMTAFVALLSLDSKRQEASRPDVVCCFSSRNLPPPKQKEGLLLCFFRKIYTPFLLHRFIRPVVLLLFLVLFGANLYLMCNISVGLDQDLALPKDSYLIDYFLFLNRYLEVGPPVYFDTTSGYNFSTEAGMNAICSSAGCESFSLTQKIQYASEFPNQSYVAIAASSWVDDFIDWLTPSSSCCRIYTRGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRPTTEQFHKYLPWFLNDTPNIRCPKGGLAAYRTSVNLSSDGQIIASQFMAYHKPLRNSQDFTEALRASRLLAANITAELRKVPGTDPNFEVFPYTISNVFYQQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDIRSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLERAKDATIFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLPVVLSYLGPDVNQALVLEEKLATEAAMVSEPSCPQYPFPADANTSDYVNYGFNPEFIPEINAASSSLPKSDQKF
uniprot
proteins
function
FUNCTION: Plays a major role in cholesterol homeostasis (PubMed:14976318, PubMed:15173162, PubMed:15671032). Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed:15173162, PubMed:15671032). Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol (PubMed:15173162). May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation (PubMed:15671032). May be involved in caveolin trafficking from the plasma membrane (PubMed:15671032). Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation (By similarity). {ECO:0000250|UniProtKB:Q9UHC9, ECO:0000269|PubMed:14976318, ECO:0000269|PubMed:15173162, ECO:0000269|PubMed:15671032}.
uniprot
proteins
mass_dalton
147132
uniprot
proteins
post_translational_modification
PTM: Highly glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
Patched family
uniprot
proteins
pubmed
14976318
uniprot
proteins
pubmed
15173162
uniprot
proteins
pubmed
15604518
uniprot
proteins
pubmed
15671032
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
29880681
uniprot
proteins
sequence_length
1333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:Q6T3U3}; Multi-pass membrane protein. Note=Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein.
uniprot
proteins
transmembrane_region
TRANSMEM 285..305; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 353..373; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 633..653; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 666..686; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 697..717; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 743..763; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 777..797; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 847..867; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 1114..1134; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 1143..1163; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 1166..1186; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 1207..1227; /note="Helical; Name=12"; /evidence="ECO:0000255"; TRANSMEM 1243..1263; /note="Helical; Name=13"; /evidence="ECO:0000255
uniprot
proteins