TLR1
entrez
7096
canonical
uniprot
Q15399
canonical
ensembl
ENSG00000174125
resolver
ensp
ENSP00000354932
resolver
ensp
ENSP00000421259
resolver
ensp
ENSP00000532643
resolver
ensp
ENSP00000532644
resolver
ensp
ENSP00000532645
resolver
ensp
ENSP00000532646
resolver
enst
ENST00000308979
resolver
enst
ENST00000502213
resolver
enst
ENST00000862584
resolver
enst
ENST00000862585
resolver
enst
ENST00000862586
resolver
enst
ENST00000862587
resolver
genesymbol
TLR1
resolver
genesymbol_syn
KIAA0012
resolver
hgnc
HGNC:11847
resolver
uniprot
D1CS39
resolver
uniprot
D1CS41
resolver
uniprot
O15452
resolver
uniprot
Q32MK3
resolver
uniprot
Q32MK4
resolver
uniprot
Q9UG90
resolver
uniprot_entry
TLR1_HUMAN
resolver
uniprot_sec
D1CS39
resolver
uniprot_sec
D1CS41
resolver
uniprot_sec
O15452
resolver
uniprot_sec
Q32MK3
resolver
uniprot_sec
Q32MK4
resolver
uniprot_sec
Q9UG90
resolver
amino_acid_sequence
MTSIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKLTEQAKK
uniprot
proteins
function
FUNCTION: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. {ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:21078852}.
uniprot
proteins
mass_dalton
90291
uniprot
proteins
protein_family
Toll-like receptor family
uniprot
proteins
pubmed
11081518
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16880211
uniprot
proteins
pubmed
17548585
uniprot
proteins
pubmed
17889651
uniprot
proteins
pubmed
18810425
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19456232
uniprot
proteins
pubmed
19924287
uniprot
proteins
pubmed
21078852
uniprot
proteins
pubmed
21618349
uniprot
proteins
pubmed
38378891
uniprot
proteins
pubmed
7584026
uniprot
proteins
pubmed
9435236
uniprot
proteins
sequence_length
786
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16880211}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9EPQ1}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:16880211}. Golgi apparatus {ECO:0000269|PubMed:16880211}. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. {ECO:0000269|PubMed:16880211}.
uniprot
proteins
transmembrane_region
TRANSMEM 581..601; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins