Ints14
entrez
300782
canonical
uniprot
Q66H58
canonical
ensembl
ENSRNOG00000012469
resolver
ensembl
ENSRNOG00055025250
resolver
ensembl
ENSRNOG00060016120
resolver
ensp
ENSRNOP00000016798
resolver
ensp
ENSRNOP00055035514
resolver
ensp
ENSRNOP00060022172
resolver
enst
ENSRNOT00000016798
resolver
enst
ENSRNOT00055043521
resolver
enst
ENSRNOT00060027594
resolver
genesymbol
Ints14
resolver
genesymbol_syn
Vwa9
resolver
uniprot_entry
INT14_RAT
resolver
amino_acid_sequence
MPTVVVMDVSLSMTRPVSVEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATQNQRSESSRFPLPFPFPSKLYVMCMANLEELQSTDSLECLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAALKCGHLTADVQVFPRPEPFVIDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGAGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVALVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPDTAHPDAAFQLTHAAQQLKLASTEYAVYDLNITPLHTDFSGSSTERM
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS14 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters. {ECO:0000250|UniProtKB:Q96SY0}.
uniprot
proteins
mass_dalton
57144
uniprot
proteins
protein_family
Integrator subunit 14 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VPY0}.
uniprot
proteins