Bcl10
entrez
12042
canonical
uniprot
Q9Z0H7
canonical
ensembl
ENSMUSG00000028191
resolver
ensp
ENSMUSP00000029842
resolver
enst
ENSMUST00000029842
resolver
genesymbol
Bcl10
resolver
genesymbol_syn
Ciper
resolver
genesymbol_syn
Clap
resolver
uniprot
B7ZWE5
resolver
uniprot
Q3UBN4
resolver
uniprot_entry
B7ZWE5_MOUSE
resolver
uniprot_entry
BCL10_MOUSE
resolver
uniprot_sec
Q3UBN4
resolver
amino_acid_sequence
MEAPAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTSSRKRAGKLLDYLQENPRGLDTLVESIRREKTQSFLIQKITDEVLKLRNIKLEHLKGLKCSSCEPFAAGATNNLSRCNSDESNLSEKQRASTVMYHPEGESSTAPFFSMASSLNLPVLEVGRTENSSFSSATLPRPGDPGAPPLPPDLRLEEGGSCGNSSEMFLPLRSRALSRQ
uniprot
proteins
function
FUNCTION: Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:22265677). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:22265677). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (By similarity). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:22265677). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (By similarity). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (By similarity). {ECO:0000250|UniProtKB:O95999, ECO:0000269|PubMed:22265677}.
uniprot
proteins
mass_dalton
25948
uniprot
proteins
mutagenesis
MUTAGEN 50; /note="E->A: Decreased interaction with CARD11."; /evidence="ECO:0000269|PubMed:22880103"; MUTAGEN 53; /note="E->A: Decreased interaction with CARD11."; /evidence="ECO:0000269|PubMed:22880103"; MUTAGEN 54; /note="E->A: Decreased interaction with CARD11."; /evidence="ECO:0000269|PubMed:22880103
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by IKBKB/IKKB. {ECO:0000250|UniProtKB:O95999}.; PTM: Ubiquitinated via both 'Lys-63'-linked and linear ('Met-1'-linked) polyubiquitin chains in response to T-cell receptor (TCR) activation. Ubiquitination is recognized by IKBKG/NEMO, the regulatory subunit of I-kappa-B kinase (IKK), and is required for TCR-induced NF-kappa-B activation. Linear ubiquitination at Lys-17, Lys-31 and Lys-63 is mediated by RNF31/HOIP; linear ubiquitination is recognized with much higher affinity than 'Lys-63'-linked ubiquitin by IKBKG/NEMO. CARD11 is required for linear ubiquitination by HOIP by promoting the targeting of BCL10 to RNF31/HOIP. {ECO:0000250|UniProtKB:O95999}.; PTM: Proteolytically cleaved by MALT1; required for T-cell activation. {ECO:0000250|UniProtKB:O95999}.
uniprot
proteins
pubmed
10187770
uniprot
proteins
pubmed
10187771
uniprot
proteins
pubmed
10187815
uniprot
proteins
pubmed
10364242
uniprot
proteins
pubmed
15213237
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22265677
uniprot
proteins
pubmed
22880103
uniprot
proteins
pubmed
9989495
uniprot
proteins
sequence_length
233
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O95999}. Membrane raft {ECO:0000250|UniProtKB:O95999}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000250|UniProtKB:O95999}.
uniprot
proteins