Csk
entrez
315707
canonical
uniprot
P32577
canonical
ensembl
ENSRNOG00000019374
resolver
ensembl
ENSRNOG00055029546
resolver
ensembl
ENSRNOG00060021015
resolver
ensembl
ENSRNOG00065017300
resolver
ensp
ENSRNOP00000026358
resolver
ensp
ENSRNOP00055042179
resolver
ensp
ENSRNOP00060030095
resolver
ensp
ENSRNOP00065022824
resolver
enst
ENSRNOT00000026358
resolver
enst
ENSRNOT00055051204
resolver
enst
ENSRNOT00060036569
resolver
enst
ENSRNOT00065028855
resolver
genesymbol
Csk
resolver
uniprot
Q4G003
resolver
uniprot_entry
CSK_RAT
resolver
uniprot_sec
Q4G003
resolver
amino_acid_sequence
MSAIQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL
uniprot
proteins
ec_number
2.7.10.4
uniprot
proteins
function
FUNCTION: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity). May act as a negative regulator of EGFR and STAT3 signaling pathways (By similarity). {ECO:0000250|UniProtKB:P41240, ECO:0000269|PubMed:1722201, ECO:0000269|PubMed:21873224, ECO:0000269|PubMed:7515063}.
uniprot
proteins
mass_dalton
50746
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated (By similarity). {ECO:0000250|UniProtKB:P41240}.
uniprot
proteins
protein_family
CSK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10801129
uniprot
proteins
pubmed
14613929
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1709258
uniprot
proteins
pubmed
1722201
uniprot
proteins
pubmed
21873224
uniprot
proteins
pubmed
7515063
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21873224}. Cell membrane {ECO:0000250|UniProtKB:P41241}. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250|UniProtKB:P41241}.
uniprot
proteins