Rec8
entrez
56739
canonical
uniprot
Q8C5S7
canonical
ensembl
ENSMUSG00000002324
resolver
ensp
ENSMUSP00000002395
resolver
enst
ENSMUST00000002395
resolver
genesymbol
Rec8
resolver
genesymbol_syn
Mei8
resolver
genesymbol_syn
Rec8L1
resolver
uniprot
Q3UIN9
resolver
uniprot
Q9JK52
resolver
uniprot_entry
REC8_MOUSE
resolver
uniprot_sec
Q3UIN9
resolver
uniprot_sec
Q9JK52
resolver
amino_acid_sequence
MFYYPNVLQRHTGCFATIWLAATRGSRLVKREYLNVNVVKTCEEILNYVLVRVQPPVAGLPRPRFSLYLSAQLQIGVIRVYFQQCQYLVEDIQHILEHLHRAQLRIRIDMEEADLPSLLLPNCLAMMETLEDAPEPFFGKMSVDPRLPSPFDIPQIRHLLEAATPEKTRKETLPEATPDPRKPDRTLATVQSPEVITLQEAEPIRMLQIEGEQDLPEISRGDLELLIAEKDDAILLEERQRGRLLRQRRASLPLDESREEPRALEGAGLVSALSPPAPAQVEGIQEALPGQVFPPEVQKMTGWEPGALLTEVTPPQELRLPAPPSTEKRLPSLQRPLPRRHRRRQLLFWDKETQISREKFEEQLQTGAHCWEYPVAQPPKRMLTSPAELFRTPTLSGWLPPELLGLWTHCAQVPQRMLRQRPQLETEETVEEERAADEEERRKTEALSEIEVLREAQEPSGPLMLSSELSLEAAEDEKSRTSLIPPEWWAWSEEGQPEPPALPMLPELPEVPMEMPPRPELSSEAVLRAVALKLQANKELDFSSLVPPLSPRKLASRVFYLLLVLSTQKILLVEQQKPYGPLLIRPGPKFP
uniprot
proteins
function
FUNCTION: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II. {ECO:0000269|PubMed:12034751, ECO:0000269|PubMed:15515002, ECO:0000269|PubMed:15935783, ECO:0000269|PubMed:16855401}.
uniprot
proteins
mass_dalton
67425
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:12759374, ECO:0000269|PubMed:22346761}.
uniprot
proteins
protein_family
Rad21 family
uniprot
proteins
pubmed
10207075
uniprot
proteins
pubmed
12034751
uniprot
proteins
pubmed
12130806
uniprot
proteins
pubmed
12759374
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15515002
uniprot
proteins
pubmed
15935783
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16855401
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22346761
uniprot
proteins
pubmed
27932493
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12034751, ECO:0000269|PubMed:12759374, ECO:0000269|PubMed:16855401, ECO:0000269|PubMed:22346761}. Chromosome {ECO:0000269|PubMed:12034751, ECO:0000269|PubMed:12759374, ECO:0000269|PubMed:16855401, ECO:0000269|PubMed:22346761}. Chromosome, centromere {ECO:0000269|PubMed:12034751, ECO:0000269|PubMed:12759374, ECO:0000269|PubMed:16855401, ECO:0000269|PubMed:22346761}. Note=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II. {ECO:0000269|PubMed:12034751, ECO:0000269|PubMed:12759374, ECO:0000269|PubMed:16855401, ECO:0000269|PubMed:22346761}.
uniprot
proteins