Scg5
entrez
20394
canonical
uniprot
P12961
canonical
ensembl
ENSMUSG00000023236
resolver
ensp
ENSMUSP00000024005
resolver
ensp
ENSMUSP00000176905
resolver
ensp
ENSMUSP00000176917
resolver
ensp
ENSMUSP00000176923
resolver
ensp
ENSMUSP00000176926
resolver
ensp
ENSMUSP00000176927
resolver
ensp
ENSMUSP00000176928
resolver
ensp
ENSMUSP00000176930
resolver
ensp
ENSMUSP00000176931
resolver
ensp
ENSMUSP00000176935
resolver
enst
ENSMUST00000024005
resolver
genesymbol
Scg5
resolver
genesymbol_syn
Sgne-1
resolver
genesymbol_syn
Sgne1
resolver
uniprot
Q3TT51
resolver
uniprot
Q8CCZ3
resolver
uniprot
Q9CYP0
resolver
uniprot
Q9D2P6
resolver
uniprot
Q9DB14
resolver
uniprot_entry
7B2_MOUSE
resolver
uniprot_entry
Q3TT51_MOUSE
resolver
uniprot_sec
Q8CCZ3
resolver
uniprot_sec
Q9CYP0
resolver
uniprot_sec
Q9D2P6
resolver
uniprot_sec
Q9DB14
resolver
amino_acid_sequence
MASRLVSAMLSGLLFWLMFEWNPAFAYSPRTPDRVSETDIQRLLHGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDFSEDQGYPDPPNPCPLGKTADDGCLENAPDTAEFSREFQLDQHLFDPEHDYPGLGKWNKKLLYEKMKGGQRRKRRSVNPYLQGKRLDNVVAKKSVPHFSEEEKEAE
uniprot
proteins
function
FUNCTION: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. {ECO:0000269|PubMed:10089884, ECO:0000269|PubMed:9348280}.
uniprot
proteins
mass_dalton
23866
uniprot
proteins
mutagenesis
MUTAGEN 177; /note="R->A: No effect on proteolytic processing. Abolishes proteolytic processing; when associated with G-178."; /evidence="ECO:0000269|PubMed:8034690"; MUTAGEN 178; /note="R->G: Abolishes proteolytic processing; when associated with A-177."; /evidence="ECO:0000269|PubMed:8034690
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides. {ECO:0000269|PubMed:8034690}.; PTM: Sulfated on tyrosine residues. {ECO:0000269|PubMed:8034690}.
uniprot
proteins
protein_family
7B2 family
uniprot
proteins
pubmed
10089884
uniprot
proteins
pubmed
11439082
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2542174
uniprot
proteins
pubmed
8016065
uniprot
proteins
pubmed
8034690
uniprot
proteins
pubmed
9348280
uniprot
proteins
sequence_length
212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01165}. Note=Neuroendocrine and endocrine secretory granules. {ECO:0000250|UniProtKB:P01165}.
uniprot
proteins