TNIP2
entrez
79155
canonical
uniprot
Q8NFZ5
canonical
ensembl
ENSG00000168884
resolver
ensp
ENSP00000321203
resolver
ensp
ENSP00000426314
resolver
ensp
ENSP00000427613
resolver
enst
ENST00000503235
resolver
genesymbol
TNIP2
resolver
genesymbol_syn
ABIN2
resolver
genesymbol_syn
FLIP1
resolver
hgnc
HGNC:19118
resolver
uniprot
B1AKS4
resolver
uniprot
B3KTY8
resolver
uniprot
D3DVQ9
resolver
uniprot
D6RGJ2
resolver
uniprot
Q7L5L2
resolver
uniprot
Q9BQR6
resolver
uniprot
Q9H682
resolver
uniprot_entry
D6RGJ2_HUMAN
resolver
uniprot_entry
TNIP2_HUMAN
resolver
uniprot_sec
B1AKS4
resolver
uniprot_sec
B3KTY8
resolver
uniprot_sec
D3DVQ9
resolver
uniprot_sec
Q7L5L2
resolver
uniprot_sec
Q9BQR6
resolver
uniprot_sec
Q9H682
resolver
amino_acid_sequence
MSRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAECCQ
uniprot
proteins
function
FUNCTION: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:11389905, ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:12753905, ECO:0000269|PubMed:12933576, ECO:0000269|PubMed:14653779, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:21784860}.
uniprot
proteins
mass_dalton
48700
uniprot
proteins
mutagenesis
MUTAGEN 62; /note="S->A: Reduces phosphorylation."; /evidence="ECO:0000269|PubMed:21784860"; MUTAGEN 146; /note="S->A: Reduces phosphorylation; reduces CHUK-mediated NF-kappa-B activation."; /evidence="ECO:0000269|PubMed:21784860"; MUTAGEN 309..310; /note="DF->NA: Abolishes ubiquitin binding."; /evidence="ECO:0000269|PubMed:18212736"; MUTAGEN 313..314; /note="ER->AA: Abolishes ubiquitin binding; loss of inhibitory activity on NF-kappa-B activation."; /evidence="ECO:0000269|PubMed:18212736
uniprot
proteins
post_translational_modification
PTM: In vitro phosphorylated by CHUK. {ECO:0000269|PubMed:21784860}.; PTM: Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probably involving deubiquitination (PubMed:21784860). Deubiquitinated by USP35; leading to stabilization and inhibition of TNFalpha-induced NF-kappa-B activation (PubMed:26348204). {ECO:0000269|PubMed:21784860, ECO:0000269|PubMed:26348204}.
uniprot
proteins
pubmed
11389905
uniprot
proteins
pubmed
11390377
uniprot
proteins
pubmed
12595760
uniprot
proteins
pubmed
12609966
uniprot
proteins
pubmed
12753905
uniprot
proteins
pubmed
12933576
uniprot
proteins
pubmed
14653779
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15169888
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18212736
uniprot
proteins
pubmed
21266526
uniprot
proteins
pubmed
21784860
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26348204
uniprot
proteins
pubmed
30617349
uniprot
proteins
sequence_length
429
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12595760}. Nucleus {ECO:0000305}.
uniprot
proteins