Q63065
uniprot
Q63065
canonical
activity_regulation
ACTIVITY REGULATION: Activated by binding to the pyruvate dehydrogenase complex subunit DLAT. Strongly activated by NADH plus acetyl-coenzyme A. Inhibited by dichloroacetate. {ECO:0000269|PubMed:11978179, ECO:0000269|PubMed:8253790, ECO:0000269|PubMed:9405293}.
uniprot
proteins
amino_acid_sequence
MRLARLLRGGTSVRPLCAVPCASRSLASDSASGSGPASESGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKTIYEFTDTVIRIRNRHNDVIPTMAQGVTEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGSPSHRKHIGSINPNCDVVEVIKDGYENARRLCDLYYVNSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHADKGVYPPIQVHVTLGEEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTESIERLPVYNKAAWKHYRTNHEADDWCVPSREPKDMTTFRSS
uniprot
proteins
ec_number
2.7.11.2
uniprot
proteins
function
FUNCTION: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. {ECO:0000269|PubMed:11486000, ECO:0000269|PubMed:12573248, ECO:0000269|PubMed:21541279, ECO:0000269|PubMed:22575885, ECO:0000269|PubMed:22948140, ECO:0000269|PubMed:8253790}.
uniprot
proteins
mass_dalton
49081
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by constitutively activated ABL1, FGFR1, FLT3 and JAK2 (in vitro), and this may also occur in cancer cells that express constitutively activated ABL1, FGFR1, FLT3 and JAK2. Phosphorylation at Tyr-241 and Tyr-242 strongly increases kinase activity, while phosphorylation at Tyr-136 has a lesser effect (By similarity). Phosphorylated under hypoxic conditions at Thr-336 by phosphoglycerate kinase PGK1 which has an activating effect (By similarity). {ECO:0000250|UniProtKB:Q15118}.
uniprot
proteins
protein_family
PDK/BCKDK protein kinase family
uniprot
proteins
pubmed
11486000
uniprot
proteins
pubmed
11723055
uniprot
proteins
pubmed
11978179
uniprot
proteins
pubmed
12573248
uniprot
proteins
pubmed
21541279
uniprot
proteins
pubmed
22575885
uniprot
proteins
pubmed
22948140
uniprot
proteins
pubmed
8253790
uniprot
proteins
pubmed
9405293
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix.
uniprot
proteins