Izumo1r
entrez
690037
canonical
uniprot
F1M928
canonical
ensembl
ENSRNOG00000019894
resolver
ensembl
ENSRNOG00055006985
resolver
ensembl
ENSRNOG00060005645
resolver
ensembl
ENSRNOG00065012049
resolver
ensp
ENSRNOP00000048978
resolver
ensp
ENSRNOP00055009055
resolver
ensp
ENSRNOP00060007052
resolver
ensp
ENSRNOP00065015023
resolver
enst
ENSRNOT00000051471
resolver
enst
ENSRNOT00055011517
resolver
enst
ENSRNOT00060009378
resolver
enst
ENSRNOT00065019591
resolver
genesymbol
Izumo1r
resolver
genesymbol_syn
Folr4
resolver
genesymbol_syn
JUNO
resolver
uniprot
A0A1B1W5N3
resolver
uniprot
A6JNA9
resolver
uniprot_entry
JUNO_RAT
resolver
uniprot_sec
A0A1B1W5N3
resolver
uniprot_sec
A6JNA9
resolver
amino_acid_sequence
MAQWWLILLGLWTVLPSLAGGKLLNVCMNSKHHKQEPGPEDKLYFECMPWKDNACCTRDTSWEAHLDEPLLFNFSMTHCGLLTPLCHKHFIQAICFYECSPNLGPWIQPVVPNRQEEQRLWDVPLCLEDCEEWWKDCRTSHTCKADWLHGWVWDQGKNGCPAHAPCLPFSDYFPTPADLCEKIWNNTFKASPERRNSGRCLQKWFEPTHGNPNVEVALHFAGSASAPQLSYSITAFSLCLLLHA
uniprot
proteins
function
FUNCTION: Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate. {ECO:0000250|UniProtKB:Q9EQF4}.
uniprot
proteins
mass_dalton
28026
uniprot
proteins
post_translational_modification
PTM: The protein is rapidly cleaved following fertilization, being only weakly detectable in zona-intact fertilized eggs at telophase II and undetectable at the pronuclear stage. Sheding is probably required to block to polyspermy and ensuring egg fusion with a single sperm. {ECO:0000250|UniProtKB:Q9EQF4}.
uniprot
proteins
protein_family
Folate receptor family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
37951137
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37951137}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9EQF4}. Cell projection, microvillus membrane {ECO:0000250|UniProtKB:A6ND01}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9EQF4}. Note=GPI-anchored at the oolemma microvilli. {ECO:0000250|UniProtKB:Q9EQF4}.
uniprot
proteins