Pcyt1a
entrez
13026
canonical
uniprot
P49586
canonical
ensembl
ENSMUSG00000005615
resolver
ensp
ENSMUSP00000078721
resolver
ensp
ENSMUSP00000110793
resolver
ensp
ENSMUSP00000130056
resolver
enst
ENSMUST00000079791
resolver
enst
ENSMUST00000104893
resolver
enst
ENSMUST00000115140
resolver
genesymbol
Pcyt1a
resolver
genesymbol_syn
Ctpct
resolver
genesymbol_syn
Pcyt1
resolver
uniprot
Q542W4
resolver
uniprot_entry
PCY1A_MOUSE
resolver
uniprot_sec
Q542W4
resolver
activity_regulation
ACTIVITY REGULATION: Interconverts between an inactive cytosolic form and an active membrane-bound form. Activation involves disruption of an inhibitory interaction between helices at the base of the active site and the autoinhibitory (AI) region. {ECO:0000250|UniProtKB:P19836}.
uniprot
proteins
amino_acid_sequence
MDAQSSAKVNSRKRRKEAPGPNGATEEDGIPSKVQRCAVGLRQPAPFSDEIEVDFSKPYVRVTMEEACRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKDAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSSPTHERSPSPSFRWPFSGKTSPSSSPASLSRCRAVTCDISEDEED
uniprot
proteins
ec_number
2.7.7.15
uniprot
proteins
function
FUNCTION: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:12842190}.
uniprot
proteins
mass_dalton
41667
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2. {ECO:0000269|PubMed:12842190}.
uniprot
proteins
post_translational_modification
PTM: The serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation (By similarity). {ECO:0000250|UniProtKB:P19836}.; PTM: Monoubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation. {ECO:0000269|PubMed:21343341}.
uniprot
proteins
protein_family
Cytidylyltransferase family
uniprot
proteins
pubmed
12842190
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15798219
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19139091
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21343341
uniprot
proteins
pubmed
7918629
uniprot
proteins
pubmed
8307580
uniprot
proteins
pubmed
9148929
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P19836}. Membrane {ECO:0000250|UniProtKB:P19836}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19836}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P49585}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19836}. Nucleus {ECO:0000250|UniProtKB:P49585}. Note=It can interconvert between an inactive cytosolic form and an active membrane-bound form. {ECO:0000250|UniProtKB:P19836}.
uniprot
proteins