Arhgef7
entrez
114559
canonical
uniprot
O55043
canonical
ensembl
ENSRNOG00000012934
resolver
ensp
ENSRNOP00000017947
resolver
ensp
ENSRNOP00000043761
resolver
ensp
ENSRNOP00000095285
resolver
ensp
ENSRNOP00000103841
resolver
enst
ENSRNOT00000043449
resolver
genesymbol
Arhgef7
resolver
genesymbol_syn
Pak3bp
resolver
genesymbol_syn
Pixb
resolver
uniprot
A0A0G2QC21
resolver
uniprot
A3KMH4
resolver
uniprot
F1LNB0
resolver
uniprot
Q52NK0
resolver
uniprot
Q923I5
resolver
uniprot_entry
A0A0G2QC21_RAT
resolver
uniprot_entry
A3KMH4_RAT
resolver
uniprot_entry
ARHG7_RAT
resolver
uniprot_entry
Q52NK0_RAT
resolver
uniprot_entry
Q923I5_RAT
resolver
uniprot_sec
F1LNB0
resolver
amino_acid_sequence
MTDNANSQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLWPLQTSEKLSSANTSYLMGNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFPNLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLHEWVEHLQRQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGTPHTTISWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSRSPKTMKKLLPKRKPERKPSDEEFAVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL
uniprot
proteins
function
FUNCTION: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
73140
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-516 by CaMK1; enhancement of GEF activity and downstream activation of RAC1. Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
10896954
uniprot
proteins
pubmed
16228008
uniprot
proteins
pubmed
16527308
uniprot
proteins
pubmed
17652093
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9659915
uniprot
proteins
sequence_length
646
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions.
uniprot
proteins