EIF1AX
entrez
1964
canonical
uniprot
P47813
canonical
ensembl
ENSG00000173674
resolver
ensp
ENSP00000368927
resolver
enst
ENST00000379607
resolver
genesymbol
EIF1AX
resolver
genesymbol_syn
EIF1A
resolver
genesymbol_syn
EIF4C
resolver
hgnc
HGNC:3250
resolver
uniprot
B2R5U5
resolver
uniprot
Q0VGC2
resolver
uniprot
Q5JPS5
resolver
uniprot
Q5JPS6
resolver
uniprot_entry
IF1AX_HUMAN
resolver
uniprot_sec
B2R5U5
resolver
uniprot_sec
Q0VGC2
resolver
uniprot_sec
Q5JPS5
resolver
uniprot_sec
Q5JPS6
resolver
amino_acid_sequence
MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQFDDIGDDDEDIDDI
uniprot
proteins
function
FUNCTION: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:9732867). This protein enhances formation of the cap-proximal complex (PubMed:9732867). Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes (PubMed:9732867). After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:35732735). Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B (PubMed:35732735). Its globular part is located in the A site of the 40S ribosomal subunit (PubMed:35732735). Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). In contrast to yeast orthologs, does not bind EIF1 (PubMed:24319994). {ECO:0000269|PubMed:24319994, ECO:0000269|PubMed:35732735, ECO:0000269|PubMed:9732867}.
uniprot
proteins
mass_dalton
16460
uniprot
proteins
protein_family
EIF-1A family
uniprot
proteins
pubmed
10678173
uniprot
proteins
pubmed
12569173
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24319994
uniprot
proteins
pubmed
25479059
uniprot
proteins
pubmed
30211544
uniprot
proteins
pubmed
35732735
uniprot
proteins
pubmed
8106356
uniprot
proteins
pubmed
9732867
uniprot
proteins
sequence_length
144
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins