IL21
entrez
59067
canonical
uniprot
Q9HBE4
canonical
ensembl
ENSG00000138684
resolver
ensp
ENSP00000477555
resolver
ensp
ENSP00000497915
resolver
genesymbol
IL-21
resolver
genesymbol
IL21
resolver
genesymbol_syn
IL21
resolver
hgnc
HGNC:6005
resolver
uniprot
A0A224B028
resolver
uniprot
A5J0L4
resolver
uniprot_entry
A0A224B028_HUMAN
resolver
uniprot_entry
IL21_HUMAN
resolver
uniprot_sec
A5J0L4
resolver
amino_acid_sequence
MRSSPGNMERIVICLMVIFLGTLVHKSSSQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency, common variable, 11 (CVID11) [MIM:615767]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269|PubMed:24746753}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (PubMed:11081504, PubMed:15178704). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity). {ECO:0000250|UniProtKB:Q9ES17, ECO:0000269|PubMed:11081504, ECO:0000269|PubMed:15178704}.
uniprot
proteins
mass_dalton
18653
uniprot
proteins
protein_family
IL-15/IL-21 family
uniprot
proteins
pubmed
11081504
uniprot
proteins
pubmed
15147560
uniprot
proteins
pubmed
15178704
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17565991
uniprot
proteins
pubmed
17673207
uniprot
proteins
pubmed
22235133
uniprot
proteins
pubmed
24746753
uniprot
proteins
sequence_length
162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11081504}.
uniprot
proteins