Pth1r
entrez
19228
canonical
uniprot
P41593
canonical
ensembl
ENSMUSG00000032492
resolver
ensp
ENSMUSP00000006005
resolver
ensp
ENSMUSP00000132064
resolver
ensp
ENSMUSP00000143298
resolver
ensp
ENSMUSP00000276441
resolver
ensp
ENSMUSP00000276448
resolver
enst
ENSMUST00000006005
resolver
enst
ENSMUST00000166716
resolver
enst
ENSMUST00000198865
resolver
genesymbol
Pth1r
resolver
genesymbol_syn
Pthr
resolver
genesymbol_syn
Pthr1
resolver
uniprot
Q62119
resolver
uniprot
Q80WU8
resolver
uniprot_entry
PTH1R_MOUSE
resolver
uniprot_sec
Q62119
resolver
uniprot_sec
Q80WU8
resolver
amino_acid_sequence
MGTARIAPSLALLLCCPVLSSAYALVDADDVFTKEEQIFLLHRAQAQCDKLLKEVLHTAANIMESDKGWTPASTSGKPRKEKAPGKFYPESKENKDVPTGSRRRGRPCLPEWDNIVCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWEVVPGHNRTWANYSECLKFMTNETREREVFDRLGMIYTVGYSMSLASLTVAVLILAYFRRLHCTRNYIHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPAAAAVGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTIFGWGLPAVFVAVWVGVRATLANTGCWDLSSGHKKWIIQVPILASVVLNFILFINIIRVLATKLRETNAGRCDTRQQYRKLLRSTLVLVPLFGVHYTVFMALPYTEVSGTLWQIQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIRKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRAGLSLPLSPRLLPATTNGHSQLPGHAKPGAPAIENETIPVTMTVPKDDGFLNGSCSGLDEEASGSARPPPLLQEEWETVM
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:8197183). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (By similarity). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (By similarity). {ECO:0000250|UniProtKB:Q03431, ECO:0000269|PubMed:8197183}.
uniprot
proteins
mass_dalton
66372
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q03431}.; PTM: Phosphorylated on multiple serine residues; these phosphorylations are important for PTH-dependent internalization. {ECO:0000250|UniProtKB:Q03431}.
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7524627
uniprot
proteins
pubmed
8197183
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8197183}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 189..212; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 220..239; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 283..306; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 321..342; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 410..428; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 441..463; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins