Q91YE6
uniprot
Q91YE6
canonical
amino_acid_sequence
MAAAAAAGAASGLPGPVAQGLKEALVDTLTGILSPVQEVRAAAEEQIKVLEVTEEFGVHLAELTVDPQGALAIRQLASVILKQYVETHWCAQSEKFRPPETTERAKIVIRELLPNGLRESISKVRSSVAYAVSAIAHWDWPEAWPQLFNLLMEMLVSGDLNAVHGAMRVLTEFTREVTDTQMPLVAPVILPEMYKIFTMAEVYGIRTRSRAVEIFTTCAHMICNMEELEKGAAKVLIFPVVQQFTEAFVQALQMPDGPTSDSGFKMEVLKAVTALVKNFPKHMVSSMQQILPIVWNTLTESAAFYVRTEVNYTEEVEDPVDSDGEVLGFENLVFSIFEFVHALLENSKFKSTVKKALPELIYYIILYMQITEEQIKVWTANPQQFVEDEDDDTFSYTVRIAAQDLLLAVATDFQNESAVALATAATRHLQEAEQTKASGTEHWWKIHEACMLALGSVKSIITDSVKNGRIHFDMHGFLTNVILADLNLSASPFLLGRALWAASRFTVAMSPELIQQFLQATVSGLHETQPPSVRISAVRAIWGYCDQLKVSESTHVLQPFLPSILDGLIHLAAQFSSEVLNLVMETLCIVCTVDPEFTASVENKICPFTIAIFLKYSNDPVVASLAQDIFKELSQIEACQGPMQMRLIPTLVSIMQAPADKIPAGLCATAIDILTTVVRNTKPPLSQLLICQAFPAVAQCTLHTDDNATMQNGGECLRAYVSVTLEQVAQWHDEQGHNGLWYVMQVVSQLLDPRTSEFTAAFVGRLVSTLISKAGRELGENLDQILRAILSKMQQAETLSVMQSLIMVFAHLVHTQLEPLLEFLCSLPGPTGKPALEFVMAEWTSRQHLFYGQYEGKVSSVALCKLLQHGINADDKRLQDIRVKGEEIYSMDEGIRTRSKSAKNPERWTNIPLLVKILKLIINELSNVMEANAARQATPAEWNQDDSNDMWEDQEEEEEEEEDGLAGQLLSDILATSKYEEDYYEDDEEDDPDALKDPLYQIDLQAYLTDFLCQFAQQPCYIMFSCHLNDNERRVLQTIGI
uniprot
proteins
function
FUNCTION: Nuclear transport receptor that mediates nuclear import of proteins, such as histones, proteasome and actin (PubMed:11493596, PubMed:11823430, PubMed:22323606). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11493596, PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11493596, PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11493596, PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11493596, PubMed:11823430). Mediates the import of pre-assembled proteasomes into the nucleus; AKIRIN2 acts as a molecular bridge between IPO9 and the proteasome complex (By similarity). Mediates the nuclear import of histones H2A, H2B, H4 and H4 (PubMed:11493596, PubMed:11823430). In addition to nuclear import, also acts as a chaperone for histones by preventing inappropriate non-nucleosomal interactions (By similarity). Mediates the nuclear import of actin (PubMed:22323606). {ECO:0000250|UniProtKB:Q96P70, ECO:0000269|PubMed:11493596, ECO:0000269|PubMed:11823430, ECO:0000269|PubMed:22323606}.
uniprot
proteins
mass_dalton
116052
uniprot
proteins
protein_family
Importin beta family
uniprot
proteins
pubmed
11493596
uniprot
proteins
pubmed
11823430
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22323606
uniprot
proteins
sequence_length
1041
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96P70}. Nucleus {ECO:0000250|UniProtKB:Q96P70}.
uniprot
proteins