Q99PM1
uniprot
Q99PM1
canonical
activity_regulation
ACTIVITY REGULATION: In liver, recruited to target gene promoters following treatment with dexamethasone and cAMP. Binding is decreased in presence of insulin. {ECO:0000250|UniProtKB:Q8BU11}.
uniprot
proteins
amino_acid_sequence
MEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVAHFDDLADPSSSQDGSFSAQYGVQTLDMPVGMTHGLMEQGGGLLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTNSLHEDGVDDFRRQLPAQKTVVVETGKKQKAPKKRKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYKDNQECQATVETVELDPVPQSQTPSPPPVTTADPASPAPASTESPALSPCIVVNSTLSSYVANQAFSGPGGQPNITKLIITKQMLPSSITMSQGGMVTVIPATVVTSRGLQLGQTSTATIQPSQQAQIATRSVLQAAAAAAASMQLPPPRLQPPPLQQMPQPPTQQQVTILQQPPPLQAMQQPPPQKVRINLQQQPPPLQSKIVPPPALKMQATVLPPTVESSPEQPMNSSPEAHTVEATSPETICEMIADVVPEVESPSQMDVELVSGSPVTLSPQPRCVRSGCENPPVISKDWDNEYCSNECVVKHCRDVFLAWVASRNPNSVVLVK
uniprot
proteins
function
FUNCTION: Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate. In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1. This regulation is independent of the insulin receptor activation. Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes. Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release (By similarity). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). {ECO:0000250|UniProtKB:O94842, ECO:0000250|UniProtKB:Q8BU11}.
uniprot
proteins
mass_dalton
66010
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
619
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BU11}. Chromosome {ECO:0000250|UniProtKB:Q8BU11}. Note=Associated with chromatin; colocalizes with RNA polymerase II (Pol II) on chromatin. {ECO:0000250|UniProtKB:Q8BU11}.
uniprot
proteins