Pex10
entrez
668173
canonical
uniprot
B1AUE5
canonical
ensembl
ENSMUSG00000029047
resolver
ensp
ENSMUSP00000099469
resolver
enst
ENSMUST00000103180
resolver
genesymbol
Pex10
resolver
uniprot_entry
PEX10_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: The E3 ubiquitin-protein ligase activity is stimulated by PEX12. {ECO:0000250|UniProtKB:O60683}.
uniprot
proteins
amino_acid_sequence
MARAGAPEVIRAAQKDEYYLGGLRSAAGEALHSLAGAKKWLEWRKEIELLSDIAYFGLTTIAGYQTLGEEYVGIIQVDPSQQRVPSRLRRAALVALHAVLPYLLDKALLPLEQELQADGDAPRASQGSLLPGGRSRSGARRWVRHHAATLTEQQRKALQRAVFILRQGFACLHRLHVAWFYIHGTFYHLAKRLAGITYLRTRRLPGEDQKARTSYGLLGLISLLHLVLSMGLRLYSFRQKQRARKEWRLHRNLSHRRSSLEDRAVCRTPLCTLCLEERRHSTATPCGHLFCWECITEWCNTKTECPLCREKFPPQKLVYLRHYR
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (By similarity). When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity). {ECO:0000250|UniProtKB:O60683, ECO:0000250|UniProtKB:Q05568}.
uniprot
proteins
mass_dalton
37157
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:O60683}.
uniprot
proteins
protein_family
Pex2/pex10/pex12 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
324
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250|UniProtKB:O60683}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..35; /note="Helical; Name=TM1"; /evidence="ECO:0000250|UniProtKB:G2Q0E2"; TRANSMEM 37..58; /note="Helical; Name=TM2"; /evidence="ECO:0000250|UniProtKB:G2Q0E2"; TRANSMEM 88..120; /note="Helical; Name=TM3"; /evidence="ECO:0000250|UniProtKB:G2Q0E2"; TRANSMEM 146..183; /note="Helical; Name=TM4"; /evidence="ECO:0000250|UniProtKB:G2Q0E2"; TRANSMEM 215..234; /note="Helical; Name=TM5"; /evidence="ECO:0000250|UniProtKB:G2Q0E2
uniprot
proteins