Chmp2a
entrez
68953
canonical
uniprot
Q9DB34
canonical
ensembl
ENSMUSG00000033916
resolver
ensp
ENSMUSP00000005711
resolver
ensp
ENSMUSP00000147393
resolver
ensp
ENSMUSP00000148218
resolver
ensp
ENSMUSP00000351901
resolver
enst
ENSMUST00000005711
resolver
enst
ENSMUST00000210587
resolver
enst
ENSMUST00000211626
resolver
genesymbol
Chmp2a
resolver
uniprot
A0A1B0GR63
resolver
uniprot_entry
A0A1B0GR63_MOUSE
resolver
uniprot_entry
CHM2A_MOUSE
resolver
amino_acid_sequence
MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVRIMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGGKKAEATASALADADADLEERLKNLRRD
uniprot
proteins
function
FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (By similarity). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. {ECO:0000250|UniProtKB:O43633}.
uniprot
proteins
mass_dalton
25134
uniprot
proteins
post_translational_modification
PTM: ISGylated in a CHMP5-dependent manner. Isgylation weakens and inhibits its interactions with VPS4A and VTA1 respectively (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
SNF7 family
uniprot
proteins
pubmed
15173323
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:O43633}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43633}; Cytoplasmic side {ECO:0000250|UniProtKB:O43633}. Cytoplasm {ECO:0000269|PubMed:15173323}. Nucleus envelope {ECO:0000250|UniProtKB:O43633}. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body. Localizes to the reforming nuclear envelope on chromatin disks during late anaphase (By similarity). {ECO:0000250|UniProtKB:O43633}.
uniprot
proteins