72307
entrez
72307
canonical
uniprot
Q3U595
canonical
ensembl
ENSMUSG00000071632
resolver
ensp
ENSMUSP00000060363
resolver
ensp
ENSMUSP00000140943
resolver
enst
ENSMUST00000055413
resolver
uniprot_entry
CV039_MOUSE
resolver
amino_acid_sequence
MAVAGSWQPPRPCEVYRAEWELCRSVGHVLHHYYVHGKRPDCRQWLRDLTNCREWEESRSAEAQRSLCESEQVRVQAAQKHTLVWALRQRPPTDWNLPLPQEKDK
uniprot
proteins
function
FUNCTION: Negatively regulates long-term potentiation and modulates adult synaptic plasticity (PubMed:35771867). Stabilizes the interaction of RTN4 isoform A/Nogo-A with its receptors, inhibiting clustering of postsynaptic AMPA receptors at synaptic sites (PubMed:35771867). Upon neuronal stimulation, degraded at synapses, reducing RTN4 signaling and allowing AMPA receptor clustering at individual synapses (PubMed:35771867). {ECO:0000269|PubMed:35771867}.
uniprot
proteins
mass_dalton
12503
uniprot
proteins
post_translational_modification
PTM: Rapidly degraded by proteolysis following neuronal stimulation, resulting in increased AMPA receptor clustering. {ECO:0000269|PubMed:35771867}.
uniprot
proteins
protein_family
UPF0545 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
29571919
uniprot
proteins
pubmed
35771867
uniprot
proteins
sequence_length
105
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000269|PubMed:35771867}. Synaptic cleft {ECO:0000269|PubMed:35771867}. Note=Detected in both the presynaptic and postsynaptic regions of the synapse and is secreted from neurons into the synaptic cleft (PubMed:35771867). May be released by neuronal dense core vesicles which mediate the release of cleaved neuropeptides (PubMed:35771867). {ECO:0000269|PubMed:35771867}.
uniprot
proteins