Igf1
entrez
16000
canonical
uniprot
P05017
canonical
ensembl
ENSMUSG00000020053
resolver
ensp
ENSMUSP00000056668
resolver
ensp
ENSMUSP00000093005
resolver
ensp
ENSMUSP00000100937
resolver
ensp
ENSMUSP00000112878
resolver
ensp
ENSMUSP00000113177
resolver
ensp
ENSMUSP00000113905
resolver
ensp
ENSMUSP00000114120
resolver
enst
ENSMUST00000062862
resolver
enst
ENSMUST00000105300
resolver
enst
ENSMUST00000121161
resolver
enst
ENSMUST00000121952
resolver
enst
ENSMUST00000122100
resolver
genesymbol
Igf1
resolver
genesymbol_syn
Igf-1
resolver
uniprot
E9PU89
resolver
uniprot
E9Q138
resolver
uniprot
F6U040
resolver
uniprot
F6ZWM7
resolver
uniprot
P05018
resolver
uniprot
Q4VJB9
resolver
uniprot
Q4VJC0
resolver
uniprot
Q6LDP4
resolver
uniprot
Q8C4U6
resolver
uniprot
Q8CAR0
resolver
uniprot_entry
E9PU89_MOUSE
resolver
uniprot_entry
E9Q138_MOUSE
resolver
uniprot_entry
F6U040_MOUSE
resolver
uniprot_entry
F6ZWM7_MOUSE
resolver
uniprot_entry
IGF1_MOUSE
resolver
uniprot_entry
Q4VJB9_MOUSE
resolver
uniprot_entry
Q4VJC0_MOUSE
resolver
uniprot_entry
Q8CAR0_MOUSE
resolver
uniprot_sec
P05018
resolver
uniprot_sec
Q6LDP4
resolver
uniprot_sec
Q8C4U6
resolver
amino_acid_sequence
MGKISSLPTQLFKICLCDFLKIKIHIMSSSHLFYLALCLLTFTSSTTAGPETLCGAELVDALQFVCGPRGFYFNKPTGYGSSIRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPTKAARSIRAQRHTDMPKTQKEVHLKNTSRGSAGNKTYRM
uniprot
proteins
function
FUNCTION: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (By similarity). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (PubMed:21496647). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity). As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). {ECO:0000250|UniProtKB:P05019, ECO:0000250|UniProtKB:P08025, ECO:0000269|PubMed:21496647}.
uniprot
proteins
mass_dalton
17093
uniprot
proteins
protein_family
Insulin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20685873
uniprot
proteins
pubmed
20881139
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21496647
uniprot
proteins
pubmed
2474537
uniprot
proteins
pubmed
3467309
uniprot
proteins
pubmed
3774549
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21496647}.
uniprot
proteins