GOSR1
entrez
9527
canonical
uniprot
O95249
canonical
ensembl
ENSG00000108587
resolver
ensp
ENSP00000225724
resolver
ensp
ENSP00000414441
resolver
ensp
ENSP00000462638
resolver
ensp
ENSP00000540856
resolver
ensp
ENSP00000678298
resolver
enst
ENST00000451249
resolver
genesymbol
GOSR1
resolver
genesymbol_syn
GS28
resolver
hgnc
HGNC:4430
resolver
uniprot
E9PCW1
resolver
uniprot
J3KST5
resolver
uniprot
O75392
resolver
uniprot_entry
E9PCW1_HUMAN
resolver
uniprot_entry
GOSR1_HUMAN
resolver
uniprot_sec
J3KST5
resolver
uniprot_sec
O75392
resolver
amino_acid_sequence
MAAGTSSYWEDLRKQARQLENELDLKLVSFSKLCTSYSHSSTRDGRRDRYSSDTTPLLNGSSQDRMFETMAIEIEQLLARLTGVNDKMAEYTNSAGVPSLNAALMHTLQRHRDILQDYTHEFHKTKANFMAIRERENLMGSVRKDIESYKSGSGVNNRRTELFLKEHDHLRNSDRLIEETISIAMATKENMTSQRGMLKSIHSKMNTLANRFPAVNSLIQRINLRKRRDSLILGGVIGICTILLLLYAFH
uniprot
proteins
function
FUNCTION: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:21860593}.
uniprot
proteins
mass_dalton
28613
uniprot
proteins
protein_family
GOSR1 family
uniprot
proteins
pubmed
10198168
uniprot
proteins
pubmed
15215310
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15728195
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17274796
uniprot
proteins
pubmed
17337506
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21669198
uniprot
proteins
pubmed
21860593
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9653160
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:15728195, ECO:0000269|PubMed:17274796, ECO:0000269|PubMed:17337506, ECO:0000269|PubMed:21669198}; Single-pass type IV membrane protein {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:15728195, ECO:0000269|PubMed:17274796, ECO:0000269|PubMed:17337506, ECO:0000269|PubMed:21669198}. Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 230..250; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins