Atp6v1a
entrez
11964
canonical
uniprot
P50516
canonical
ensembl
ENSMUSG00000052459
resolver
ensp
ENSMUSP00000066886
resolver
ensp
ENSMUSP00000110314
resolver
ensp
ENSMUSP00000271461
resolver
ensp
ENSMUSP00000271462
resolver
genesymbol
Atp6v1a
resolver
genesymbol_syn
Atp6a1
resolver
genesymbol_syn
Atp6a2
resolver
genesymbol_syn
Atp6v1a1
resolver
uniprot
Q3TKS0
resolver
uniprot
Q3U5W3
resolver
uniprot
Q3U777
resolver
uniprot
Q3UDZ9
resolver
uniprot
Q3US31
resolver
uniprot
Q8CHX2
resolver
uniprot_entry
VATA_MOUSE
resolver
uniprot_sec
Q3TKS0
resolver
uniprot_sec
Q3U5W3
resolver
uniprot_sec
Q3U777
resolver
uniprot_sec
Q3UDZ9
resolver
uniprot_sec
Q3US31
resolver
uniprot_sec
Q8CHX2
resolver
activity_regulation
ACTIVITY REGULATION: ATP hydrolysis occurs at the interface between the nucleotide-binding domains of subunits A and B (By similarity). ATP hydrolysis triggers a conformational change in the subunits D and F, which induces a shift of subunit d (By similarity). The c-ring is subsequently rotated and results in a continuous proton translocation across the membrane (By similarity). {ECO:0000250|UniProtKB:P31404}.
uniprot
proteins
amino_acid_sequence
MDFSKLPKIRDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDIKWEFIPSKNLRVGSHITGGDIYGIVNENSLIKHKIMLPPRNRGSVTYIAPPGNYDASDVVLELEFEGVKEKFSMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYMRALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGMLSNMISFYDMARRAVETTAQSDNKITWSIIREHMGEILYKLSSMKFKDPVKDGEAKIKADYAQLLEDMQNAFRSLED
uniprot
proteins
ec_number
7.1.2.2
uniprot
proteins
function
FUNCTION: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:23863464). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in neurite development and synaptic connectivity (By similarity). {ECO:0000250|UniProtKB:P38606, ECO:0000269|PubMed:23863464}.
uniprot
proteins
mass_dalton
68326
uniprot
proteins
mutagenesis
MUTAGEN 384; /note="S->A: Significant loss in AMPK-mediated phosphorylation."; /evidence="ECO:0000269|PubMed:23863464"; MUTAGEN 411; /note="S->A: Reduces the interaction with CRYAB and MTOR."; /evidence="ECO:0000269|PubMed:31786107
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-384 by AMPK down-regulates its enzyme activity. {ECO:0000269|PubMed:23863464}.
uniprot
proteins
protein_family
ATPase alpha/beta chains family
uniprot
proteins
pubmed
11495928
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23863464
uniprot
proteins
pubmed
31786107
uniprot
proteins
pubmed
8741845
uniprot
proteins
sequence_length
617
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23863464}. Cytoplasm, cytosol {ECO:0000269|PubMed:31786107}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P38606}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P31404}; Peripheral membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:31786107}; Peripheral membrane protein {ECO:0000305}. Note=Co-localizes with WFS1 in the secretory granules in neuroblastoma cell lines. {ECO:0000250|UniProtKB:P38606}.
uniprot
proteins