TLR6
entrez
10333
canonical
uniprot
Q9Y2C9
canonical
ensembl
ENSG00000174130
resolver
ensp
ENSP00000371376
resolver
ensp
ENSP00000424718
resolver
genesymbol
TLR6
resolver
hgnc
HGNC:16711
resolver
uniprot
B2R933
resolver
uniprot
B3Y640
resolver
uniprot
B6CH35
resolver
uniprot
B6RFS4
resolver
uniprot
B6RFS5
resolver
uniprot
Q2NKL3
resolver
uniprot_entry
B2R933_HUMAN
resolver
uniprot_entry
TLR6_HUMAN
resolver
uniprot_sec
B3Y640
resolver
uniprot_sec
B6CH35
resolver
uniprot_sec
B6RFS4
resolver
uniprot_sec
B6RFS5
resolver
uniprot_sec
Q2NKL3
resolver
amino_acid_sequence
MTKDKEPIVKSFHFVCLMIIIVGTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSELVPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAAFNMKLTLVTENNDVKS
uniprot
proteins
function
FUNCTION: Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion (PubMed:11441107, PubMed:20037584). {ECO:0000269|PubMed:11441107, ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:20037584}.
uniprot
proteins
mass_dalton
91880
uniprot
proteins
mutagenesis
MUTAGEN 678; /note="F->A: Does not inhibit homodimer formation."; /evidence="ECO:0000269|PubMed:25088687"; MUTAGEN 712; /note="C->R: Inhibits homodimer formation."; /evidence="ECO:0000269|PubMed:25088687"; MUTAGEN 716; /note="L->R: Inhibits homodimer formation."; /evidence="ECO:0000269|PubMed:25088687
uniprot
proteins
protein_family
Toll-like receptor family
uniprot
proteins
pubmed
10231569
uniprot
proteins
pubmed
11441107
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16880211
uniprot
proteins
pubmed
18810425
uniprot
proteins
pubmed
20037584
uniprot
proteins
pubmed
21618349
uniprot
proteins
pubmed
25088687
uniprot
proteins
sequence_length
796
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20037584}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9EPW9}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:16880211}. Golgi apparatus {ECO:0000269|PubMed:16880211}. Note=Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis. Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus (PubMed:16880211). {ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:20037584}.
uniprot
proteins
transmembrane_region
TRANSMEM 587..607; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins