INTS4
entrez
92105
canonical
uniprot
Q96HW7
canonical
ensembl
ENSG00000149262
resolver
ensp
ENSP00000434466
resolver
ensp
ENSP00000441084
resolver
ensp
ENSP00000511686
resolver
ensp
ENSP00000511692
resolver
ensp
ENSP00000511696
resolver
ensp
ENSP00000686989
resolver
ensp
ENSP00000777415
resolver
enst
ENST00000535943
resolver
enst
ENST00000695096
resolver
enst
ENST00000695101
resolver
enst
ENST00000695105
resolver
genesymbol
INTS4
resolver
hgnc
HGNC:25048
resolver
uniprot
A0A8C8UVZ7
resolver
uniprot
A0A8Q3SHL8
resolver
uniprot
A0A8Q3SHT4
resolver
uniprot
A0A8Q3WKB5
resolver
uniprot
Q2YD62
resolver
uniprot
Q6PJG4
resolver
uniprot
Q7Z4E7
resolver
uniprot
Q96G32
resolver
uniprot
Q96GA1
resolver
uniprot
Q9BRC0
resolver
uniprot_entry
A0A8C8UVZ7_HUMAN
resolver
uniprot_entry
A0A8Q3SHL8_HUMAN
resolver
uniprot_entry
A0A8Q3SHT4_HUMAN
resolver
uniprot_entry
A0A8Q3WKB5_HUMAN
resolver
uniprot_entry
INT4_HUMAN
resolver
uniprot_sec
Q2YD62
resolver
uniprot_sec
Q6PJG4
resolver
uniprot_sec
Q7Z4E7
resolver
uniprot_sec
Q96G32
resolver
uniprot_sec
Q96GA1
resolver
uniprot_sec
Q9BRC0
resolver
amino_acid_sequence
MAAHLKKRVYEEFTKVVQPQEEIATKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFARKPVEAESVEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQNEKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSLEKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKLLSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRVQAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPKEEVDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKEGIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMDDPAYIAVLVLIFNAAKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVSPSIIPQEDPSQQFLQQSLERVYSLQHLDPQGAQELLEFTIRDLQRLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSHTAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIMPKPARR
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:29471365, PubMed:33243860, PubMed:33548203, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS4 acts as an scaffold that links INTS9 and INTS11 (PubMed:29471365, PubMed:33548203). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:29471365, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33548203, ECO:0000269|PubMed:38570683}.
uniprot
proteins
mass_dalton
108171
uniprot
proteins
mutagenesis
MUTAGEN 164..167; /note="HGVR->AGVA: Decreased processing activity of the Integrator complex."; /evidence="ECO:0000269|PubMed:33548203"; MUTAGEN 210; /note="R->A: Decreased processing activity of the Integrator complex."; /evidence="ECO:0000269|PubMed:33548203
uniprot
proteins
protein_family
Integrator subunit 4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16239144
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23904267
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29471365
uniprot
proteins
pubmed
33243860
uniprot
proteins
pubmed
33548203
uniprot
proteins
pubmed
34762484
uniprot
proteins
pubmed
36869814
uniprot
proteins
pubmed
38570683
uniprot
proteins
pubmed
39032489
uniprot
proteins
pubmed
39032490
uniprot
proteins
sequence_length
963
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:29471365, ECO:0000269|PubMed:39032489, ECO:0000269|PubMed:39032490}. Cytoplasm {ECO:0000269|PubMed:29471365}.
uniprot
proteins