Cbarp
entrez
100503659
canonical
uniprot
Q66L44
canonical
ensembl
ENSMUSG00000035640
resolver
ensp
ENSMUSP00000101008
resolver
ensp
ENSMUSP00000131487
resolver
ensp
ENSMUSP00000250373
resolver
enst
ENSMUST00000105369
resolver
enst
ENSMUST00000170219
resolver
genesymbol
Cbarp
resolver
genesymbol_syn
Barp
resolver
genesymbol_syn
Dos
resolver
genesymbol_syn
R29144/1
resolver
uniprot
E9QP85
resolver
uniprot
Q497H6
resolver
uniprot
Q8CBL1
resolver
uniprot
Q9QZY3
resolver
uniprot_entry
CBARP_MOUSE
resolver
uniprot_sec
E9QP85
resolver
uniprot_sec
Q497H6
resolver
uniprot_sec
Q8CBL1
resolver
uniprot_sec
Q9QZY3
resolver
amino_acid_sequence
MQPTATMATAAATTATVALTTSWDNATSRPTAEPDPILDNYVLLVVVMSLFVGGTLVVLSGVLLLCKRCWEVHQRFNRAMEEAEKTTTTYLDNGTHPIQDPDCRGEDPEGQDTETERFLATSSTGRRVSFNEAALFEQSRKAQDKGRRYTLTEGDFHHLKNARLTHLHLPPLKIATIHECDSGEASAAATPHPATTSKDSLAIFQPPGKTLTGHSVGPSSALPGGPYNSVDFSEISPSTSSDSGEGISLDAGTRGAKAAGPETVPGEMGTGSSGSGTVLQFFTRLRRHASLDGASPYFKVKKWKLEPSQRASSLDTRGSPKRHHFQRQRAASESMEQEGDVPHADFIQYIASAGDSVAFPPPRPFLASPTSPPPTLGRLEAAEAAGGASPETPPEHGISLGPEHAQQQDPQQEQDAEHAQCSYRDLWSLRASLELHAATASDHSSSGNDRDSVRSGDSSGSGSGGGGAAPAFPPPPESPPALRPKDGEARRLLQMDSGYASIEGRGAGDEVSELPAPARSPPRSPRAWPRRPRRDYSIDEKTDALFHEFLRHDPHFDDAPRHRTRAHPHTHARKQWQQRGRQHSDPGGARAATPPGVARPTRAPLRRGDSVDCPPEGRALPITGDDPSIPVIEEEPGGGGGGCPGSGLCVEPAGALLDKLAASLDERLFSPRLAEPVASSQVLIVAAAAPTSPDHSPA
uniprot
proteins
function
FUNCTION: Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000269|PubMed:24751537}.
uniprot
proteins
mass_dalton
74131
uniprot
proteins
mutagenesis
MUTAGEN 25; /note="N->Q: Loss of N-glycosylation."; /evidence="ECO:0000269|PubMed:24751537"; MUTAGEN 426..427; /note="LW->AA: Loss of interaction with CACNB3 and loss of the ability to negatively regulate voltage-dependent L-type calcium channel; when associated with 545-A--A-550."; /evidence="ECO:0000269|PubMed:24751537"; MUTAGEN 545..550; /note="LFHEFL->AAHEAA: Loss of interaction with CACNB3 and loss of the ability to negatively regulate voltage-dependent L-type calcium channel; when associated with 426-A-A-427."; /evidence="ECO:0000269|PubMed:24751537
uniprot
proteins
pubmed
10400995
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24751537
uniprot
proteins
sequence_length
698
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:24751537}; Single-pass type III membrane protein {ECO:0000305|PubMed:24751537}. Cell membrane {ECO:0000269|PubMed:24751537}; Single-pass type III membrane protein {ECO:0000305|PubMed:24751537}. Cell projection, growth cone {ECO:0000269|PubMed:24751537}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..62; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins