Dsg3
entrez
13512
canonical
uniprot
O35902
canonical
ensembl
ENSMUSG00000056632
resolver
ensp
ENSMUSP00000064718
resolver
enst
ENSMUST00000070892
resolver
genesymbol
Dsg3
resolver
uniprot
F7BUX6
resolver
uniprot
Q3UFC6
resolver
uniprot
Q8CB02
resolver
uniprot
Q8CE48
resolver
uniprot_entry
DSG3_MOUSE
resolver
uniprot_entry
F7BUX6_MOUSE
resolver
uniprot_entry
Q3UFC6_MOUSE
resolver
uniprot_sec
Q8CB02
resolver
uniprot_sec
Q8CE48
resolver
amino_acid_sequence
MTCLFPRALGSLALLMVVLLVQGELHVKPGGQHREDGTALQLAKRRYKREWVKFAKPCREREDNSRRNPIAKITSDFQKNQKITYRISGVGIDQPPFGIFVVDPNNGDINITAIVDREETPSFLITCRALNALGQDVERPLILTVKILDVNDNPPIFSQTIFKGEIEENSASNSLVMILNATDADEPNHMNSKIAFKIVSQEPAGMSMFLISRNTGEVRTLTSSLDREQISSYHLVVSGADNDGTGLSTQCECSIKIKDVNDNFPVLRESQYSARIEENTLNAELLRFQVTDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILKVVKALDYEQVQSMQFSIAVRNKAEFHQSVISQYRVQSTPVTIQVIDVREGISFRPPSKTFTVQRGVSTNKLVGYILGTYQATDEDTGKAASSVRYVLGRNDGGLLVIDSKTAQIKFVKNIDRDSTFIVNKTISAEVLAIDENTGKTSTGTIYVEVPSFNENCPSVVLEKKDICTSSPSVTLSVRTLDRGKYTGPYTVSLEEQPLKLPVMWTITTLNATSALLQAQQQVSPGVYNVPVIVKDNQDGLCDTPESLTLTVCQCDDRSMCRAPIPSREPNTYGESSWRLGPAAIGLILLGLLMLLLAPLLLLTCDCGSGPIGGAATGGFIPVPDGSEGTIHQWGIEGAQPEDKEITNICVPPVTTNGADFMESSEVCTNTYAGGTMVEGASGMEMITKLGGATGATAALGPCSLGYSGTMRTRHSTGGTLKDYAAPVNMTFLGSYFSQKSLAYAEEEDEREVNDCLLIYDDEGEDAAPHSPTLSSCSIFGDDLDDNFLDSLGPKFKKLAEICLGIDDEAKQAKPGPKDSGSGADTCARSMEVPQSGSNRYQTLPGSLEVTQTGSKICHTLSGNQETSVMSTSGSVHPAVAIPDPLQLGNYLLTETYSTSGSFAQPTTVTFDPHVTQNVTVTERVICPLPSASSSIVAPTELRGSYNMLYTKETCSHL
uniprot
proteins
function
FUNCTION: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:9166409). Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes (By similarity). Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle (PubMed:9166409, PubMed:9701552). Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells (PubMed:9166409). May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3 (By similarity). Required for YAP1 localization at the plasma membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, PKP1 and YWHAG (By similarity). May also be involved in the positive regulation of YAP1 target gene transcription and as a result cell proliferation (By similarity). Positively regulates cellular contractility and cell junction formation via organization of cortical F-actin bundles and anchoring of actin to tight junctions, in conjunction with RAC1 (By similarity). The cytoplasmic pool of DSG3 is required for the localization of CDH1 and CTNNB1 at developing adherens junctions, potentially via modulation of SRC activity (By similarity). Inhibits keratinocyte migration via suppression of p38MAPK signaling, may therefore play a role in moderating wound healing (PubMed:26763450). {ECO:0000250|UniProtKB:P32926, ECO:0000250|UniProtKB:Q7YRU7, ECO:0000269|PubMed:26763450, ECO:0000269|PubMed:9166409, ECO:0000269|PubMed:9701552}.
uniprot
proteins
mass_dalton
107889
uniprot
proteins
pubmed
12787123
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18343367
uniprot
proteins
pubmed
26763450
uniprot
proteins
pubmed
30660666
uniprot
proteins
pubmed
30949721
uniprot
proteins
pubmed
34905516
uniprot
proteins
pubmed
7894164
uniprot
proteins
pubmed
9166409
uniprot
proteins
pubmed
9701552
uniprot
proteins
sequence_length
993
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9701552}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, desmosome {ECO:0000269|PubMed:9166409}. Cytoplasm {ECO:0000250|UniProtKB:P32926}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q7YRU7}. Cell junction {ECO:0000269|PubMed:18343367}.
uniprot
proteins
transmembrane_region
TRANSMEM 618..638; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins