CISH
entrez
1154
canonical
uniprot
Q9NSE2
canonical
ensembl
ENSG00000114737
resolver
ensp
ENSP00000294173
resolver
ensp
ENSP00000409346
resolver
genesymbol
CISH
resolver
genesymbol_syn
G18
resolver
hgnc
HGNC:1984
resolver
uniprot
B2R9N1
resolver
uniprot
G5E9R1
resolver
uniprot
Q9NS38
resolver
uniprot
Q9Y5R1
resolver
uniprot_entry
CISH_HUMAN
resolver
uniprot_sec
B2R9N1
resolver
uniprot_sec
G5E9R1
resolver
uniprot_sec
Q9NS38
resolver
uniprot_sec
Q9Y5R1
resolver
amino_acid_sequence
MVLCVQGPRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDCLPLPRRMADYLRQYPFQL
uniprot
proteins
function
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
28663
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Association with EPOR may target the protein for proteolysis by the ubiquitin-dependent proteasome pathway. CIS is mainly monubiquitinated (37 kDa form) but may also exist in a polyubiquitinated form (45 kDa). {ECO:0000269|PubMed:9774439}.
uniprot
proteins
pubmed
10902923
uniprot
proteins
pubmed
11032736
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
20484391
uniprot
proteins
pubmed
9465889
uniprot
proteins
pubmed
9774439
uniprot
proteins
sequence_length
258
uniprot
proteins