RAD54L
entrez
8438
canonical
uniprot
Q92698
canonical
ensembl
ENSG00000085999
resolver
ensp
ENSP00000361043
resolver
ensp
ENSP00000396113
resolver
ensp
ENSP00000499652
resolver
ensp
ENSP00000602598
resolver
ensp
ENSP00000602600
resolver
enst
ENST00000371975
resolver
enst
ENST00000442598
resolver
enst
ENST00000671528
resolver
enst
ENST00000932539
resolver
enst
ENST00000932541
resolver
genesymbol
RAD54L
resolver
genesymbol_syn
RAD54A
resolver
hgnc
HGNC:9826
resolver
uniprot
A8K996
resolver
uniprot
Q5TE31
resolver
uniprot
Q6IUY3
resolver
uniprot_entry
A8K996_HUMAN
resolver
uniprot_entry
RAD54_HUMAN
resolver
uniprot_sec
Q5TE31
resolver
uniprot_sec
Q6IUY3
resolver
amino_acid_sequence
MRRSLAPSQLAKRKPEGRSCDDEDWQPGLVTPRKRKSSSETQIQECFLSPFRKPLSQLTNQPPCLDSSQHEAFIRSILSKPFKVPIPNYQGPLGSRALGLKRAGVRRALHDPLEKDALVLYEPPPLSAHDQLKLDKEKLPVHVVVDPILSKVLRPHQREGVKFLWECVTSRRIPGSHGCIMADEMGLGKTLQCITLMWTLLRQSPECKPEIDKAVVVSPSSLVKNWYNEVGKWLGGRIQPLAIDGGSKDEIDQKLEGFMNQRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVHFVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEERLRELTSIVNRCLIRRTSDILSKYLPVKIEQVVCCRLTPLQTELYKRFLRQAKPAEELLEGKMSVSSLSSITSLKKLCNHPALIYDKCVEEEDGFVGALDLFPPGYSSKALEPQLSGKMLVLDYILAVTRSRSSDKVVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPDFVFMLSSKAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLLSAGTIEEKIFQRQSHKKALSSCVVDEEQDVERHFSLGELKELFILDEASLSDTHDRLHCRRCVNSRQIRPPPDGSDCTSDLAGWNHCTDKWGLRDEVLQAAWDAASTAITFVFHQRSHEEQRGLR
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Multifunctional ATPase that plays a role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:11459989, PubMed:12205100, PubMed:24798879, PubMed:27264870, PubMed:32457312, PubMed:9774452). Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity). {ECO:0000250|UniProtKB:P32863, ECO:0000269|PubMed:11459989, ECO:0000269|PubMed:12205100, ECO:0000269|PubMed:24798879, ECO:0000269|PubMed:27264870, ECO:0000269|PubMed:32457312, ECO:0000269|PubMed:9774452}.
uniprot
proteins
mass_dalton
84352
uniprot
proteins
mutagenesis
MUTAGEN 189; /note="K->R: Loss of dsDNA-dependent ATPase activity. Loss of function in double-strand break repair based on complementation assays in yeast."; /evidence="ECO:0000269|PubMed:11884632, ECO:0000269|PubMed:8805304"; MUTAGEN 515; /note="K->R: Loss of acetylation."; /evidence="ECO:0000269|PubMed:32457312"; MUTAGEN 572; /note="S->A: Defect in homologous recombination (HR)."; /evidence="ECO:0000269|PubMed:27264870"; MUTAGEN 572; /note="S->E: Promotes homologous recombination (HR), but causes RAD51 removal from chromatin."; /evidence="ECO:0000269|PubMed:27264870
uniprot
proteins
post_translational_modification
PTM: Acetylated. Acetylation promotes interaction with BRD9, and subsequently with RAD54, which is essential for homologous recombination (HR). {ECO:0000269|PubMed:32457312}.; PTM: Phosphorylated. Phosphorylation at Ser-572 by NEK1 specifically in G2 phase allows efficient removal of RAD51 filaments from DNA. {ECO:0000269|PubMed:27264870}.
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
10362365
uniprot
proteins
pubmed
10449612
uniprot
proteins
pubmed
11459989
uniprot
proteins
pubmed
11884632
uniprot
proteins
pubmed
12205100
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24798879
uniprot
proteins
pubmed
27264870
uniprot
proteins
pubmed
32457312
uniprot
proteins
pubmed
8805304
uniprot
proteins
pubmed
9192813
uniprot
proteins
pubmed
9321665
uniprot
proteins
pubmed
9774452
uniprot
proteins
sequence_length
747
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8805304}.
uniprot
proteins