Nipal1
entrez
70701
canonical
uniprot
Q8BMW7
canonical
ensembl
ENSMUSG00000067219
resolver
ensp
ENSMUSP00000084462
resolver
enst
ENSMUST00000087212
resolver
genesymbol
Nipal1
resolver
genesymbol_syn
Nipa3
resolver
genesymbol_syn
Npal1
resolver
uniprot_entry
NIPA3_MOUSE
resolver
amino_acid_sequence
MGVQLRLPPGEPCHEGYVLSLVCSNSSRASCEITNVSESLPYPVVYTNLNSSKTNFSISASVENKYNLYVGLVLAISSSVFIGSSFILKKKGLLQLADKGITRAGQGGHSYLKEWLWWAGLLSMGAGEAANFAAYAFAPATLVTPLGALSVLISAILSSYFLNERLNIHGKIGCILSVLGSTVMVIHAPQEGEVTSLHEMEMKLRDPGFVSFAVIISVISLVLILIVAPKKGQTNILVYIAICSLIGAFSVSSVKGLGIAIKELLERKPVYKDPLFFILLTMLALSVTTQINYLNKALDTFNTSLVTPIYYVFFTSMVVTCSAILFQEWYGMKAGDIIGTLSGFFTIINGIFLLHAFKNTNITWSELMSTAKKEALSPNGNQNSYVLLENADFSASGYDDDITLFSRTNDQSSHKL
uniprot
proteins
function
FUNCTION: Acts as a Mg(2+) transporter (PubMed:18667602). Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (PubMed:18667602). Shown to promote insulin content and secretion in Min6-K8 cells, particularly under conditions of hypomagnesemia (PubMed:32439805). {ECO:0000269|PubMed:18667602, ECO:0000269|PubMed:32439805}.
uniprot
proteins
mass_dalton
45159
uniprot
proteins
protein_family
NIPA family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18667602
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
32439805
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:32439805}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 68..88; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 137..157; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 166..186; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 208..228; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 234..254; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 274..294; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 306..326; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 337..357; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins