ANXA13
entrez
312
canonical
uniprot
P27216
canonical
ensembl
ENSG00000104537
resolver
ensp
ENSP00000262219
resolver
ensp
ENSP00000390809
resolver
genesymbol
ANXA13
resolver
genesymbol_syn
ANX13
resolver
hgnc
HGNC:536
resolver
uniprot
Q53FB5
resolver
uniprot
Q9BQR5
resolver
uniprot_entry
ANX13_HUMAN
resolver
uniprot_entry
Q53FB5_HUMAN
resolver
uniprot_sec
Q9BQR5
resolver
amino_acid_sequence
MGNRHAKASSPQGFDVDRDAKKLNKACKGMGTNEAAIIEILSGRTSDERQQIKQKYKATYGKELEEVLKSELSGNFEKTALALLDRPSEYAARQLQKAMKGLGTDESVLIEVLCTRTNKEIIAIKEAYQRLFDRSLESDVKGDTSGNLKKILVSLLQANRNEGDDVDKDLAGQDAKDLYDAGEGRWGTDELAFNEVLAKRSYKQLRATFQAYQILIGKDIEEAIEEETSGDLQKAYLTLVRCAQDCEDYFAERLYKSMKGAGTDEETLIRIVVTRAEVDLQGIKAKFQEKYQKSLSDMVRSDTSGDFRKLLVALLH
uniprot
proteins
function
FUNCTION: [Isoform A]: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner (PubMed:27676605, PubMed:30610115). Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup (PubMed:27676605). {ECO:0000269|PubMed:27676605, ECO:0000269|PubMed:30610115}.; FUNCTION: [Isoform B]: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium. {ECO:0000269|PubMed:27676605}.
uniprot
proteins
mass_dalton
35415
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Loss of myristoylation. Loss of location at the cell membrane."; /evidence="ECO:0000269|PubMed:30610115"; MUTAGEN 32..34; /note="TNE->PGP: Loss of dimerization. No effect on calcium-dependent membrane binding and location at the cell membrane."; /evidence="ECO:0000269|PubMed:30610115"; MUTAGEN 73; /note="S->C: Slightly increased dimerization. Decreases calcium-dependent membrane binding and location at the cell membrane."; /evidence="ECO:0000269|PubMed:30610115
uniprot
proteins
protein_family
Annexin family
uniprot
proteins
pubmed
11961095
uniprot
proteins
pubmed
1530946
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27676605
uniprot
proteins
pubmed
30610115
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:1530946}. Cell membrane {ECO:0000269|PubMed:30610115}; Lipid-anchor {ECO:0000269|PubMed:30610115}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q99JG3}. Note=Myristoylation anchors the protein to the membrane, but the protein also displays calcium-dependent, reversible binding to lipid membranes (PubMed:30610115). Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes (PubMed:1530946). {ECO:0000269|PubMed:1530946, ECO:0000269|PubMed:30610115}.
uniprot
proteins