CLK2
entrez
1196
canonical
uniprot
P49760
canonical
ensembl
ENSG00000176444
resolver
ensembl
ENSG00000261893
resolver
ensp
ENSP00000347759
resolver
ensp
ENSP00000354856
resolver
ensp
ENSP00000357345
resolver
ensp
ENSP00000458788
resolver
enst
ENST00000355560
resolver
enst
ENST00000576584
resolver
genesymbol
CLK2
resolver
hgnc
HGNC:2069
resolver
uniprot
A8K7I0
resolver
uniprot
B1AVS9
resolver
uniprot
B1AVT0
resolver
uniprot
B5MBX6
resolver
uniprot
B7Z8N6
resolver
uniprot
E7EQU3
resolver
uniprot
Q96CQ0
resolver
uniprot_entry
A8K7I0_HUMAN
resolver
uniprot_entry
B1AVT0_HUMAN
resolver
uniprot_entry
B7Z8N6_HUMAN
resolver
uniprot_entry
CLK2_HUMAN
resolver
uniprot_sec
B1AVS9
resolver
uniprot_sec
B5MBX6
resolver
uniprot_sec
E7EQU3
resolver
uniprot_sec
Q96CQ0
resolver
activity_regulation
ACTIVITY REGULATION: 5,6-dichloro-1-b-D-ribofuranosylbenzimidazole (DRB) inhibits autophosphorylation. TG003 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR
uniprot
proteins
ec_number
2.7.12.1
uniprot
proteins
function
FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:28289210). {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:28289210, ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}.
uniprot
proteins
mass_dalton
60090
uniprot
proteins
post_translational_modification
PTM: Autophosphorylates on all three types of residues. Phosphorylation on Ser-34 and Thr-127 by AKT1 is induced by ionizing radiation or insulin. Phosphorylation plays a critical role in cell proliferation following low dose radiation and prevents cell death following high dose radiation. Phosphorylation at Thr-344 by PKB/AKT2 induces its kinase activity which is required for its stability. The phosphorylation status at Ser-142 influences its subnuclear localization; inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle. {ECO:0000269|PubMed:20682768, ECO:0000269|PubMed:9637771}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Lammer subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10480872
uniprot
proteins
pubmed
12705895
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19168442
uniprot
proteins
pubmed
19282290
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20682768
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28289210
uniprot
proteins
pubmed
7990150
uniprot
proteins
pubmed
8910305
uniprot
proteins
pubmed
9331372
uniprot
proteins
pubmed
9637771
uniprot
proteins
sequence_length
499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28289210}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:9637771}. Nucleus speckle {ECO:0000269|PubMed:9637771}. Note=Inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle. {ECO:0000250|UniProtKB:O35491}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus speckle {ECO:0000269|PubMed:9637771}. Note=Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles. {ECO:0000269|PubMed:9637771}.
uniprot
proteins