Mtdh
entrez
170910
canonical
uniprot
Q9Z1W6
canonical
ensembl
ENSRNOG00000006870
resolver
ensp
ENSRNOP00000009989
resolver
ensp
ENSRNOP00000077252
resolver
ensp
ENSRNOP00000078672
resolver
ensp
ENSRNOP00000088806
resolver
enst
ENSRNOT00000009989
resolver
enst
ENSRNOT00000105848
resolver
enst
ENSRNOT00000108860
resolver
genesymbol
Mtdh
resolver
genesymbol_syn
Lyric
resolver
uniprot
A0A8I5ZLQ8
resolver
uniprot
A0A8I6AJK9
resolver
uniprot
A0A8L2UIC6
resolver
uniprot_entry
A0A8I5ZLQ8_RAT
resolver
uniprot_entry
A0A8I6AJK9_RAT
resolver
uniprot_entry
A0A8L2UIC6_RAT
resolver
uniprot_entry
LYRIC_RAT
resolver
amino_acid_sequence
MAARSWQDELAQQAEEGSARLRELLSVGLGFLRTELGLDLGLEPKRYPSWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEVTPPTPAPEDPAQLKNLRSEEQKKKNRKKLPEKPKPNGRTVEIPEDEVVRTPRSITAKQPPETDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENITVNGGGWSEKSVKLSSQLSAGEEKWNSVPPASAGKRKTEQSAWTQDPGDTNANGKDWGRNWSDRSIFSGIGSTAEPVSQSTTSDYQWDGSRNQPHIDDEWSGLNGLSSADPSSDWNAPAEEWGNWVDEDRASLLKSQEPISNDQKDSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSITQDTEDLEKDTREELPVNTSKARPKQEKACSLKTMSTSDPVEVLIKNSQPIKTLPPAISAEPSVTLSKGDSDKSSSQVPPMLQDTDKPKSNAKQNSVPPSQTKSETNWESPKQIKKKKKARRET
uniprot
proteins
function
FUNCTION: Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
63969
uniprot
proteins
pubmed
15383321
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
581
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain. TNF causes translocation from the cytoplasm to the nucleus (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 50..70; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins