Ninj2
entrez
59115
canonical
uniprot
Q9JHE8
canonical
genesymbol
Ninj2
resolver
uniprot_entry
NINJ2_RAT
resolver
amino_acid_sequence
MESDREIIHLQHRHSTPGGNQRHINLNHYATKKSVAESMLDVALFMSNAMRLKSVLEQGPFSQYYTTLLTLISASLLLQVVIGILLVVIARLNLNEVENQWRLNQLNNAATTLVFITVVINIFITAFGAHKTGSVAARTSSNPI
uniprot
proteins
function
FUNCTION: Its role in unclear. In contrast to NINJ1 paralog, does not mediate plasma membrane rupture (cytolysis) downstream of necroptotic and pyroptotic programmed cell death. While it is able to oligomerize and form filaments, filaments are curved toward the intracellular space, preventing circularization to mediate plasma membrane rupture. May act as a homophilic transmembrane adhesion molecule involved in nerve regeneration. Promotes axonal growth. {ECO:0000250|UniProtKB:Q9NZG7}.
uniprot
proteins
mass_dalton
15996
uniprot
proteins
protein_family
Ninjurin family
uniprot
proteins
sequence_length
144
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NZG7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NZG7}.
uniprot
proteins
transmembrane_region
TRANSMEM 63..94; /note="Helical; Name=Helix alpha3"; /evidence="ECO:0000250|UniProtKB:Q9NZG7"; TRANSMEM 99..128; /note="Helical;Name=Helix alpha4"; /evidence="ECO:0000250|UniProtKB:Q9NZG7
uniprot
proteins