Dnmt3b
entrez
13436
canonical
uniprot
O88509
canonical
ensembl
ENSMUSG00000027478
resolver
ensp
ENSMUSP00000051830
resolver
ensp
ENSMUSP00000072761
resolver
ensp
ENSMUSP00000080334
resolver
ensp
ENSMUSP00000086370
resolver
ensp
ENSMUSP00000099439
resolver
ensp
ENSMUSP00000099440
resolver
ensp
ENSMUSP00000105393
resolver
ensp
ENSMUSP00000105394
resolver
ensp
ENSMUSP00000105395
resolver
ensp
ENSMUSP00000105396
resolver
ensp
ENSMUSP00000220843
resolver
ensp
ENSMUSP00000220844
resolver
ensp
ENSMUSP00000220847
resolver
ensp
ENSMUSP00000220850
resolver
ensp
ENSMUSP00000336837
resolver
enst
ENSMUST00000056495
resolver
enst
ENSMUST00000109771
resolver
genesymbol
Dnmt3b
resolver
genesymbol_syn
Dnmt3b6
resolver
uniprot
F7AP54
resolver
uniprot
O88510
resolver
uniprot
O88511
resolver
uniprot
Q3KR45
resolver
uniprot
Q541E5
resolver
uniprot_entry
DNM3B_MOUSE
resolver
uniprot_entry
F7AP54_MOUSE
resolver
uniprot_entry
Q3KR45_MOUSE
resolver
uniprot_entry
Q541E5_MOUSE
resolver
uniprot_sec
O88510
resolver
uniprot_sec
O88511
resolver
activity_regulation
ACTIVITY REGULATION: Activated by binding to the regulatory factor DNMT3L. {ECO:0000269|PubMed:15671018}.
uniprot
proteins
amino_acid_sequence
MKGDSRHLNEEEGASGYEECIIVNGNFSDQSSDTKDAPSPPVLEAICTEPVCTPETRGRRSSSRLSKREVSSLLNYTQDMTGDGDRDDEVDDGNGSDILMPKLTRETKDTRTRSESPAVRTRHSNGTSSLERQRASPRITRGRQGRHHVQEYPVEFPATRSRRRRASSSASTPWSSPASVDFMEEVTPKSVSTPSVDLSQDGDQEGMDTTQVDAESRDGDSTEYQDDKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMPGMRWVQWFGDGKFSEISADKLVALGLFSQHFNLATFNKLVSYRKAMYHTLEKARVRAGKTFSSSPGESLEDQLKPMLEWAHGGFKPTGIEGLKPNKKQPVVNKSKVRRSDSRNLEPRRRENKSRRRTTNDSAASESPPPKRLKTNSYGGKDRGEDEESRERMASEVTNNKGNLEDRCLSCGKKNPVSFHPLFEGGLCQSCRDRFLELFYMYDEDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGAGTAEDAKLQEPWSCYMCLPQRCHGVLRRRKDWNMRLQDFFTTDPDLEEFEPPKLYPAIPAAKRRPIRVLSLFDGIATGYLVLKELGIKVEKYIASEVCAESIAVGTVKHEGQIKYVNDVRKITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYTRPKEGDNRPFFWMFENVVAMKVNDKKDISRFLACNPVMIDAIKVSAAHRARYFWGNLPGMNRPVMASKNDKLELQDCLEFSRTAKLKKVQTITTKSNSIRQGKNQLFPVVMNGKDDVLWCTELERIFGFPAHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
uniprot
proteins
ec_number
2.1.1.37
uniprot
proteins
function
FUNCTION: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Functions as a transcriptional corepressor by associating with ZHX1 (By similarity). Required for DUX4 silencing in somatic cells (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9UBC3, ECO:0000269|PubMed:10555141, ECO:0000269|PubMed:11836534, ECO:0000269|PubMed:11919202, ECO:0000269|PubMed:16567415, ECO:0000269|PubMed:18056424, ECO:0000269|PubMed:18567530}.
uniprot
proteins
mass_dalton
97228
uniprot
proteins
mutagenesis
MUTAGEN 236..237; /note="VW->RR: Prevents accumulation in pericentric heterochromatin."; /evidence="ECO:0000269|PubMed:15456878"; MUTAGEN 277; /note="S->P: Prevents accumulation in pericentric heterochromatin."; /evidence="ECO:0000269|PubMed:15456878"; MUTAGEN 609; /note="A->T: Significantly reduces activity."; /evidence="ECO:0000269|PubMed:11919202"; MUTAGEN 656..657; /note="PC->GT: No effect on localization."; /evidence="ECO:0000269|PubMed:15456878"; MUTAGEN 669; /note="G->S: Significantly reduces activity."; /evidence="ECO:0000269|PubMed:11919202"; MUTAGEN 670; /note="L->T: Significantly reduces activity."; /evidence="ECO:0000269|PubMed:11919202"; MUTAGEN 725; /note="V->G: Loss of activity."; /evidence="ECO:0000269|PubMed:11919202"; MUTAGEN 823; /note="D->G: Significantly reduces activity."; /evidence="ECO:0000269|PubMed:11919202"; MUTAGEN 824; /note="V->M: Significantly reduces activity."; /evidence="ECO:0000269|PubMed:11919202
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000250}.; PTM: Citrullinated by PADI4. {ECO:0000269|PubMed:24463520}.
uniprot
proteins
protein_family
C5-methyltransferase family
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
10555141
uniprot
proteins
pubmed
11836534
uniprot
proteins
pubmed
11919202
uniprot
proteins
pubmed
12567489
uniprot
proteins
pubmed
12867029
uniprot
proteins
pubmed
15456878
uniprot
proteins
pubmed
15671018
uniprot
proteins
pubmed
16085498
uniprot
proteins
pubmed
16357870
uniprot
proteins
pubmed
16567415
uniprot
proteins
pubmed
18056424
uniprot
proteins
pubmed
18567530
uniprot
proteins
pubmed
18814855
uniprot
proteins
pubmed
19798101
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24463520
uniprot
proteins
pubmed
9662389
uniprot
proteins
sequence_length
859
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15456878}. Note=Accumulates in the major satellite repeats at pericentric heterochromatin.
uniprot
proteins