SLC2A7
entrez
155184
canonical
uniprot
Q6PXP3
canonical
ensembl
ENSG00000197241
resolver
ensp
ENSP00000383698
resolver
enst
ENST00000400906
resolver
genesymbol
SLC2A7
resolver
genesymbol_syn
GLUT7
resolver
hgnc
HGNC:13445
resolver
uniprot
A2A333
resolver
uniprot_entry
GTR7_HUMAN
resolver
uniprot_sec
A2A333
resolver
activity_regulation
ACTIVITY REGULATION: Glucose and fructose transport are inhibited by the flavonoid apigenin. {ECO:0000269|PubMed:29548810}.
uniprot
proteins
amino_acid_sequence
MENKEAGTPPPIPSREGRLQPTLLLATLSAAFGSAFQYGYNLSVVNTPHKVFKSFYNETYFERHATFMDGKLMLLLWSCTVSMFPLGGLLGSLLVGLLVDSCGRKGTLLINNIFAIIPAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQIFSLQAILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYSLIQKGDEATARQALRRLRGHTDMEAELEDMRAEARAERAEGHLSVLHLCALRSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERLGRRHLLLAGYGICGSACLVLTVVLLFQNRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMVDGAVHWLTNFIIGFLFPSIQEAIGAYSFIIFAGICLLTAIYIYVVIPETKGKTFVEINRIFAKRNRVKLPEEKEETIDAGPPTASPAKETSF
uniprot
proteins
function
FUNCTION: Probable sugar transporter (PubMed:28083649). Even if its physiological substrate is subject to discussion, it is able to transport glucose and fructose (PubMed:16186102, PubMed:28083649, PubMed:29548810). Does not transport galactose, 2-deoxy-d-glucose and xylose (PubMed:15033637). {ECO:0000269|PubMed:15033637, ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:29548810}.
uniprot
proteins
mass_dalton
55728
uniprot
proteins
mutagenesis
MUTAGEN 302; /note="I->S: Does not affect glucose or fructose transport."; /evidence="ECO:0000269|PubMed:16186102"; MUTAGEN 302; /note="I->V: Abolished fructose transport."; /evidence="ECO:0000269|PubMed:16186102
uniprot
proteins
protein_family
Glucose transporter subfamily
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sugar transporter (TC 2.A.1.1) family
uniprot
proteins
pubmed
15033637
uniprot
proteins
pubmed
16186102
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
28083649
uniprot
proteins
pubmed
29548810
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:28083649}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:29548810}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 108..128; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 199..219; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 282..302; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 322..342; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 351..371; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 380..400; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 416..436; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 446..466; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins