GGA2
entrez
23062
canonical
uniprot
Q9UJY4
canonical
ensembl
ENSG00000103365
resolver
ensp
ENSP00000311962
resolver
enst
ENST00000309859
resolver
genesymbol
GGA2
resolver
genesymbol_syn
KIAA1080
resolver
hgnc
HGNC:16064
resolver
uniprot
D3DWF0
resolver
uniprot
O14564
resolver
uniprot
Q9NYN2
resolver
uniprot
Q9UPS2
resolver
uniprot_entry
GGA2_HUMAN
resolver
uniprot_sec
D3DWF0
resolver
uniprot_sec
O14564
resolver
uniprot_sec
Q9NYN2
resolver
uniprot_sec
Q9UPS2
resolver
amino_acid_sequence
MAATAVAAAVAGTESAQGPPGPAASLELWLNKATDPSMSEQDWSAIQNFCEQVNTDPNGPTHAPWLLAHKIQSPQEKEALYALTVLEMCMNHCGEKFHSEVAKFRFLNELIKVLSPKYLGSWATGKVKGRVIEILFSWTVWFPEDIKIRDAYQMLKKQGIIKQDPKLPVDKILPPPSPWPKSSIFDADEEKSKLLTRLLKSNHPEDLQAANRLIKNLVKEEQEKSEKVSKRVSAVEEVRSHVKVLQEMLSMYRRPGQAPPDQEALQVVYERCEKLRPTLFRLASDTTDDDDALAEILQANDLLTQGVLLYKQVMEGRVTFGNRVTSSLGDIPVSRVFQNPAGCMKTCPLIDLEVDNGPAQMGTVVPSLLHQDLAALGISDAPVTGMVSGQNCCEEKRNPSSSTLPGGGVQNPSADRNLLDLLSAQPAPCPLNYVSQKSVPKEVPPGTKSSPGWSWEAGPLAPSPSSQNTPLAQVFVPLESVKPSSLPPLIVYDRNGFRILLHFSQTGAPGHPEVQVLLLTMMSTAPQPVWDIMFQVAVPKSMRVKLQPASSSKLPAFSPLMPPAVISQMLLLDNPHKEPIRLRYKLTFNQGGQPFSEVGEVKDFPDLAVLGAA
uniprot
proteins
function
FUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}.
uniprot
proteins
mass_dalton
67150
uniprot
proteins
mutagenesis
MUTAGEN 349..353; /note="LIDLE->AADAA: Partial loss of clathrin-binding."; /evidence="ECO:0000269|PubMed:11301005
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. {ECO:0000250}.
uniprot
proteins
protein_family
GGA protein family
uniprot
proteins
pubmed
10470851
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
10702286
uniprot
proteins
pubmed
10747088
uniprot
proteins
pubmed
10749927
uniprot
proteins
pubmed
10814529
uniprot
proteins
pubmed
11301005
uniprot
proteins
pubmed
11331584
uniprot
proteins
pubmed
11387475
uniprot
proteins
pubmed
11390366
uniprot
proteins
pubmed
11821067
uniprot
proteins
pubmed
11886874
uniprot
proteins
pubmed
11950392
uniprot
proteins
pubmed
12429846
uniprot
proteins
pubmed
12505986
uniprot
proteins
pubmed
12606052
uniprot
proteins
pubmed
12808037
uniprot
proteins
pubmed
14567678
uniprot
proteins
pubmed
14638859
uniprot
proteins
pubmed
14665628
uniprot
proteins
pubmed
15039775
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15615712
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27901063
uniprot
proteins
pubmed
28289207
uniprot
proteins
sequence_length
613
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:10749927, ECO:0000269|PubMed:15039775, ECO:0000269|PubMed:28289207}; Peripheral membrane protein {ECO:0000269|PubMed:10749927, ECO:0000269|PubMed:15039775}. Endosome membrane {ECO:0000269|PubMed:15039775}; Peripheral membrane protein {ECO:0000269|PubMed:15039775}. Early endosome membrane {ECO:0000269|PubMed:11950392}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins