Jarid2
entrez
16468
canonical
uniprot
Q62315
canonical
ensembl
ENSMUSG00000038518
resolver
ensp
ENSMUSP00000037774
resolver
ensp
ENSMUSP00000134205
resolver
ensp
ENSMUSP00000134675
resolver
ensp
ENSMUSP00000264601
resolver
genesymbol
Jarid2
resolver
genesymbol_syn
Jmj
resolver
uniprot
Q3TPU4
resolver
uniprot
Q3UHS7
resolver
uniprot
Q99LD1
resolver
uniprot_entry
JARD2_MOUSE
resolver
uniprot_sec
Q3TPU4
resolver
uniprot_sec
Q3UHS7
resolver
uniprot_sec
Q99LD1
resolver
amino_acid_sequence
MSKERPKRNIIQKKYDDSDGIPWSEERVVRKVLYLSLKEFKNAQKRQHGEGLAGSLKAVNGLLGNAQAKALGPASEQSENEKDDASQVSSTSNDVSSSDFEEGPSRKRPRLQAQRKFAQSQPNSPSTTPVKIVEPLLPPPATQISDLSKRKPKTEDFLTFLCLRGSPALPNSMVYFGSSQDEEDVEEEDDETEDVKATTNNASSSCQSTPRKGKTHKHVHNGHVFNGSSRSAREKEPAHKHRSKEATPGKEKHSEPRADSRREQASGAQPTAASAAASSAKGLAANHQPPPSHRSAQDLRKQVSKVNGVTRMSSLGAGTNSAKKIREVRPSPSKTVKYTATVTKGTVTYTKAKRELVKETKPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASKSTGPAASGLKASSRLNPKSCTKEVGGRQLREGLRNSKRRLEEAQQVDKPQSPPKKMKGVAGNAEAPGKKASAASGEKSLLNGHVKKEVPERSLERNRPKRAAAGKNMLGKQAHGKTEGTPCENRSTSQPESSHKPHDPQGKPEKGSGKSGWAAMDEIPVLRPSAKEFHDPLIYIESVRAQVEKYGMCRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPNVQRLACIKKHLRSQGITMDELPLIGGCELDLACFFRLINEMGGMQQVTDLKKWNKLADMLRIPKTAQDRLAKLQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGPLEGHTESDHHKFHSLPRFEPKNGLVHGVTPRNGFRSKLKEVGRAPLKTGRRRLFAQEKEVVKEEEEDKGVLNDFHKCIYKGRSVSLTTFYRTARNIMNMCFSKEPAPAEIEQEYWRLVEEKDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTGSILRHLGAVPGVTIPWLNIGMVFSTSCWSRDQNHLPYIDYLHTGADCIWYCIPAEEENKLEDVVHTLLQGNGTPGLQMLESNVMISPEVLCKKGIKVHRTVQQSGQFVVCFPGSFVSKVCCGYNVSETVHFATTQWTSMGFETAKEMKRRHIAKPFSMEKLLYQIAQAEAKKENGPTLSTISALLDELRDTELRQRRLLFEAGLHSSARYGSHDGNSTVADGKKKPRKWLQLETSERRCQICQHLCYLSMVVQENENVVFCLECALRHVEKQKSCRGLKLMYRYDEEQIISLVNQICGKVSGKHGGIENCLNKPTPKRGPRKRATVDVPPSRLPSS
uniprot
proteins
function
FUNCTION: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:10807864, PubMed:12852854, PubMed:12890668, PubMed:15542826, PubMed:15870077, PubMed:19010785, PubMed:20064375, PubMed:20064376, PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20064375, PubMed:20064376). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20064375, PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (PubMed:12852854, PubMed:12890668, PubMed:19010785). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (PubMed:15542826). Participates in the negative regulation of cell proliferation signaling (PubMed:10913339). Does not have histone demethylase activity (PubMed:20064376). {ECO:0000269|PubMed:10807864, ECO:0000269|PubMed:10913339, ECO:0000269|PubMed:12852854, ECO:0000269|PubMed:12890668, ECO:0000269|PubMed:15542826, ECO:0000269|PubMed:15870077, ECO:0000269|PubMed:19010785, ECO:0000269|PubMed:20064375, ECO:0000269|PubMed:20064376, ECO:0000269|PubMed:20075857, ECO:0000269|PubMed:31914400}.
uniprot
proteins
mass_dalton
137445
uniprot
proteins
mutagenesis
MUTAGEN 106..107; /note="RK->AA: Leads to cytoplasmic relocalization."; /evidence="ECO:0000269|PubMed:12890668
uniprot
proteins
protein_family
JARID2 family
uniprot
proteins
pubmed
10446263
uniprot
proteins
pubmed
10807864
uniprot
proteins
pubmed
10913339
uniprot
proteins
pubmed
12852854
uniprot
proteins
pubmed
12890668
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15542826
uniprot
proteins
pubmed
15870077
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17521633
uniprot
proteins
pubmed
19010785
uniprot
proteins
pubmed
19455710
uniprot
proteins
pubmed
20064375
uniprot
proteins
pubmed
20064376
uniprot
proteins
pubmed
20075857
uniprot
proteins
pubmed
26523946
uniprot
proteins
pubmed
31914400
uniprot
proteins
pubmed
7758946
uniprot
proteins
pubmed
9376320
uniprot
proteins
sequence_length
1234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:10807864, ECO:0000269|PubMed:10913339, ECO:0000269|PubMed:20064375, ECO:0000269|PubMed:20064376}. Note=Colocalizes with the PRC2 complex on chromatin.
uniprot
proteins