Srd5a1
entrez
78925
canonical
uniprot
Q68FF9
canonical
ensembl
ENSMUSG00000021594
resolver
ensp
ENSMUSP00000089097
resolver
ensp
ENSMUSP00000356015
resolver
enst
ENSMUST00000091514
resolver
genesymbol
Srd5a1
resolver
uniprot
A0A0R4J136
resolver
uniprot
Q505K7
resolver
uniprot
Q8BUR8
resolver
uniprot_entry
A0A0R4J136_MOUSE
resolver
uniprot_entry
Q8BUR8_MOUSE
resolver
uniprot_entry
S5A1_MOUSE
resolver
uniprot_sec
Q505K7
resolver
amino_acid_sequence
MELDELCLLDALVYLEGFLAFVAFVGLQMVGSSYGRYSSQWSGRRVPARPAWFLQELPSMAWPLYECIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLIRGGKPTLLFTFVLAFLFCTLNGYLQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGETGYKIPRGGLFEYVSSANYFGELVEWCGFALASWSLQGVVFALFTLCALFTRARQHHQWYLEKFEDYPKTRKILIPFLL
uniprot
proteins
ec_number
1.3.1.22
uniprot
proteins
function
FUNCTION: Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms. Converts testosterone into 5-alpha-dihydrotestosterone (DHT), a more potent androgen as it is the preferred ligand for androgen receptor (AR) transactivation, making this reaction a key step in male sexual differentiation during development. Besides testosterone, it can also act on other steroids, including progesterone, androstenedione, and corticoids, producing metabolites with diverse roles. Hence, it plays a central role in sexual differentiation and androgen physiology. {ECO:0000250|UniProtKB:P24008}.
uniprot
proteins
mass_dalton
29344
uniprot
proteins
protein_family
Steroid 5-alpha reductase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
255
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 107..127; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 205..225; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins