Kcnh8
entrez
211468
canonical
uniprot
P59111
canonical
ensembl
ENSMUSG00000035580
resolver
ensp
ENSMUSP00000049206
resolver
enst
ENSMUST00000039366
resolver
genesymbol
Kcnh8
resolver
uniprot
F6TUN6
resolver
uniprot
Q8BX82
resolver
uniprot_entry
F6TUN6_MOUSE
resolver
uniprot_entry
KCNH8_MOUSE
resolver
uniprot_sec
Q8BX82
resolver
amino_acid_sequence
MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSCSCKFLFGVETNEQLMLQIEKSLEEKVEFKGEIMFYKKNGAPFWCLLDIVPIKNEKGDVVLFLASFKDITDTKVKITSEDKKEDRTKGRSRAGSHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAFPEYKASDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNEDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSTVSQAEPKGNGSINKRLPSIVEDEEEEEVEEEETTSLSPIYTRGSSVSHSKKTGSNKTYLGLSLKQLASGTVPFHSPIRVSSANSPKTKQEADPPNHGRKKEKNLKVQLSSLGSAGTPELSPRIVDGIEDGNSNEETQTFDFGSEQIRPEPRISPPLAESEIGAAFLFIKAEETKQQINKLNSEVTTLTQEVSQLGRDMRSIMQLLENILSPQQPSQFCSLHPTPMCPSRESLQTRVSWSAHQPCLHLQAGGAHLYHGNVASGIWSVDPSLVGSSPQRTEAHEQNPADSELHHSPNLDYSPSHCQVIQEGHLQFLRCISPHSDTTLTPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSITHGPVSSFSLENLPGSWDREQMMSASSERLENFPVEVVTSTADVKDSKAINV
uniprot
proteins
function
FUNCTION: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents. Elicits a slowly activating, non-inactivating and slowly deactivation outwards potassium current at depolarizating voltages from -30 mV to +50mV. Shows no obvious change in the activation rate from different holding potentials. Activation is strongly dependent on the pH of the external solution. {ECO:0000250|UniProtKB:Q9QWS8}.
uniprot
proteins
mass_dalton
123277
uniprot
proteins
protein_family
H (Eag) (TC 1.A.1.20) subfamily
uniprot
proteins
protein_family
Kv12.1/KCNH8 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
1102
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 226..246; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 256..276; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 299..319; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 328..348; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 358..378; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 449..469; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins