Cers3
entrez
545975
canonical
uniprot
Q1A3B0
canonical
ensembl
ENSMUSG00000030510
resolver
ensp
ENSMUSP00000069238
resolver
genesymbol
Cers3
resolver
genesymbol_syn
Lass3
resolver
uniprot
E9PVY9
resolver
uniprot
Q195J4
resolver
uniprot_entry
CERS3_MOUSE
resolver
uniprot_sec
E9PVY9
resolver
uniprot_sec
Q195J4
resolver
amino_acid_sequence
MFQTFRKWFWSERYWLPPTIKWSDLEDHDGLVFVKASHLYITIPYAFLLMVVRYFFEKFVATPLANALGIKKTQHKIKPNAILENFFKHSTSKPSHTDIYGLAKKCNLTERQVERWLRIRQKQNKPCRLQKFQESCWRFTFYLLITMAGAVFLYDKPWAYDLWEVWNDYPRQPLLPSQYWYYILEMSFYWSLVFSLSTDIKRKDFLAHVIHHLAAISLMSFSWCANYIRSGTLVMFIHDISDIWLESAKMFSYAGWKQTCNTLFFIFTVVFFISRFIIFPFWILYCTLILPLHYLEPFFSYIFLNLQLMILQGLHVYWGYFILKMLNRCIFTQNVQDVRSDNEEEEEEEEEEEAESTKGKETEYLKNGLGTNRHLIANGQHGR
uniprot
proteins
ec_number
2.3.1.24
uniprot
proteins
ec_number
2.3.1.297
uniprot
proteins
ec_number
2.3.1.298
uniprot
proteins
function
FUNCTION: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very- and ultra-long-chain fatty acyl-CoA (chain length greater than C22) (PubMed:16753040, PubMed:18541923, PubMed:22038835). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:16753040, PubMed:18541923, PubMed:22038835). It is crucial for the synthesis of ultra-long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:22038835). {ECO:0000269|PubMed:16753040, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:22038835}.
uniprot
proteins
mass_dalton
46081
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:16753040, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:22038835}.
uniprot
proteins
protein_family
Sphingosine N-acyltransferase family
uniprot
proteins
pubmed
16753040
uniprot
proteins
pubmed
18541923
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22038835
uniprot
proteins
sequence_length
383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22038835}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 174..194; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 205..225; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 263..283; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 302..322; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins