FBXO34
entrez
55030
canonical
uniprot
Q9NWN3
canonical
ensembl
ENSG00000178974
resolver
ensp
ENSP00000313159
resolver
ensp
ENSP00000394117
resolver
ensp
ENSP00000504946
resolver
ensp
ENSP00000505815
resolver
ensp
ENSP00000505918
resolver
ensp
ENSP00000506304
resolver
ensp
ENSP00000506349
resolver
ensp
ENSP00000506499
resolver
ensp
ENSP00000525416
resolver
ensp
ENSP00000525417
resolver
ensp
ENSP00000525418
resolver
ensp
ENSP00000525419
resolver
ensp
ENSP00000525420
resolver
ensp
ENSP00000588810
resolver
ensp
ENSP00000588811
resolver
ensp
ENSP00000639232
resolver
ensp
ENSP00000639233
resolver
ensp
ENSP00000794096
resolver
enst
ENST00000313833
resolver
enst
ENST00000440021
resolver
enst
ENST00000679934
resolver
enst
ENST00000680658
resolver
enst
ENST00000680682
resolver
enst
ENST00000681074
resolver
enst
ENST00000681400
resolver
enst
ENST00000681904
resolver
enst
ENST00000855357
resolver
enst
ENST00000855358
resolver
enst
ENST00000855359
resolver
enst
ENST00000855360
resolver
enst
ENST00000855361
resolver
enst
ENST00000918751
resolver
enst
ENST00000918752
resolver
enst
ENST00000969173
resolver
enst
ENST00000969174
resolver
genesymbol
FBXO34
resolver
genesymbol_syn
FBX34
resolver
hgnc
HGNC:20201
resolver
uniprot
Q2VPB5
resolver
uniprot
Q4VBP5
resolver
uniprot
Q86TY4
resolver
uniprot_entry
FBX34_HUMAN
resolver
uniprot_sec
Q2VPB5
resolver
uniprot_sec
Q4VBP5
resolver
uniprot_sec
Q86TY4
resolver
amino_acid_sequence
MHLKPYWKLQKKEHPPEVSRETQRTPMNHQKAVNDETCKASHITSSVFPSASLGKASSRKPFGILSPNVLCSMSGKSPVESSLNVKTKKNAPSATIHQGEEEGPLDIWAVVKPGNTKEKIAFFASHQCSNRIGSMKIKSSWDIDGRATKRRKKSGDLKKAKVQVERMREVNSRCYQPEPFACGIEHCSVHYVSDSGDGVYAGRPLSVIQMVAFLEQRASALLASCSKNCTNSPAIVRFSGQSRGVPAVSESYSAPGACEEPTERGNLEVGEPQSEPVRVLDMVAKLESECLKRQGQREPGSLSRNNSFRRNVGRVLLANSTQADEGKTKKGVLEAPDTQVNPVGSVSVDCGPSRADRCSPKEDQAWDGASQDCPPLPAGVSFHIDSAELEPGSQTAVKNSNRYDVEMTDELVGLPFSSHTYSQASELPTDAVDCMSRELVSLTSRNPDQRKESLCISITVSKVDKDQPSILNSCEDPVPGMLFFLPPGQHLSDYSQLNESTTKESSEASQLEDAAGGDSASEEKSGSAEPFVLPASSVESTLPVLEASSWKKQVSHDFLETRFKIQQLLEPQQYMAFLPHHIMVKIFRLLPTKSLVALKCTCCYFKFIIEYYNIRPADSRWVRDPRYREDPCKQCKKKYVKGDVSLCRWHPKPYCQALPYGPGYWMCCHRSQKGFPGCKLGLHDNHWVPACHSFNRAIHKKAKGTEAEEEY
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex promoting ubiquitination and proteasomal degradation of specific target proteins including HNRNPU (PubMed:36285453). Regulates both the G2/M transition and anaphase entry in meiotic oocytes (By similarity). {ECO:0000250|UniProtKB:Q80XI1, ECO:0000269|PubMed:36285453}.; FUNCTION: (Microbial infection) Plays a positive role in latent HIV-1 activation. Mechanistically, promotes hnRNP U/HNRNPU ubiquitination, which leads to its degradation and abolishment of the interaction between hnRNP U and HIV-1 Rev mRNA. {ECO:0000269|PubMed:36285453}.
uniprot
proteins
mass_dalton
78711
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
36285453
uniprot
proteins
sequence_length
711
uniprot
proteins