Nrbf2
entrez
641340
canonical
uniprot
Q8VCQ3
canonical
ensembl
ENSMUSG00000075000
resolver
ensp
ENSMUSP00000097254
resolver
enst
ENSMUST00000077839
resolver
genesymbol
Nrbf2
resolver
uniprot
Q9DCG3
resolver
uniprot_entry
NRBF2_MOUSE
resolver
uniprot_sec
Q9DCG3
resolver
amino_acid_sequence
MEVMEGPLNLAHQQSRRADRLLAAGKYEEAISCHRKATTYLSEAMKLTESEQAHLSLELQRDSHMKQLLLIQERWKRAKREERLKAQQSTERDGAPHLQAPPRPSEDAEGQSPLLSQPYIPSTERRLPEVQGVFDRDPDTLLFLLQQKNEPSEPCIGSKAPKDDKTIIEEQATKIADLKRHVEFLVAENERLRKENKQLKAEKARLLKGTAEKELDVDADFVEKSELWGLPSHSESAAASSTWQKFAANTGKAKDIPIPNLPPLDFPSPELPLMELSEDILKGFMND
uniprot
proteins
function
FUNCTION: May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) (By similarity). {ECO:0000250|UniProtKB:Q96F24}.; FUNCTION: Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (By similarity). Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (PubMed:24849286). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (By similarity). May be involved in autophagosome biogenesis (By similarity). May play a role in neural progenitor cell survival during differentiation (PubMed:18619852). {ECO:0000250|UniProtKB:Q96F24, ECO:0000269|PubMed:18619852, ECO:0000269|PubMed:24849286}.; FUNCTION: Involved in the induction of starvation-induced autophagy. Modulates ATG14-linked lipid kinase activity of PIK3C3 and stabilizes PI3K complex I (PI3KC3-C1) assembly (PubMed:24849286). May play a role in neural progenitor cell survival during differentiation (PubMed:18619852). {ECO:0000250|UniProtKB:Q96F24, ECO:0000269|PubMed:18619852, ECO:0000269|PubMed:24849286}.
uniprot
proteins
mass_dalton
32501
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18619852
uniprot
proteins
pubmed
24849286
uniprot
proteins
sequence_length
287
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9QYK3}. Cytoplasm {ECO:0000269|PubMed:18619852}. Cytoplasmic vesicle, autophagosome {ECO:0000305}.
uniprot
proteins