Nampt
entrez
297508
canonical
uniprot
Q80Z29
canonical
ensembl
ENSRNOG00000009754
resolver
ensembl
ENSRNOG00055005845
resolver
ensembl
ENSRNOG00060009387
resolver
ensembl
ENSRNOG00065010787
resolver
ensp
ENSRNOP00000013043
resolver
ensp
ENSRNOP00000071458
resolver
ensp
ENSRNOP00055007270
resolver
ensp
ENSRNOP00060012355
resolver
ensp
ENSRNOP00065013401
resolver
enst
ENSRNOT00000013043
resolver
enst
ENSRNOT00055009454
resolver
enst
ENSRNOT00060015828
resolver
enst
ENSRNOT00065017469
resolver
genesymbol
Nampt
resolver
genesymbol_syn
Pbef1
resolver
uniprot
Q2VT47
resolver
uniprot_entry
NAMPT_RAT
resolver
uniprot_sec
Q2VT47
resolver
amino_acid_sequence
MNAAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKVRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKEVYREHFQDDVFNERGWNYILEKYDGHLPIEVKAVPEGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGIALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTEAPLIIRPDSGNPLDTVLKVLDILGKKFPVSENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKKWSIENVSFGSGGALLQKLTRDLLNCSFKCSYVVTNGLGVNVFKDPVADPNKRSKKGRLSLHRTPAGTFVTLEEGKGDLEEYGHDLLHTVFKNGKVTKSYSFDEVRKNAQLNMEQDVAPH
uniprot
proteins
ec_number
2.4.2.12
uniprot
proteins
function
FUNCTION: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. {ECO:0000250|UniProtKB:P43490, ECO:0000250|UniProtKB:Q99KQ4}.
uniprot
proteins
mass_dalton
55438
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.
uniprot
proteins
protein_family
NAPRTase family
uniprot
proteins
pubmed
12782293
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16901503
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12782293}. Cytoplasm {ECO:0000269|PubMed:12782293}. Secreted {ECO:0000250|UniProtKB:P43490}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000250|UniProtKB:P43490}.
uniprot
proteins