Cbr1
entrez
29224
canonical
uniprot
P47727
canonical
genesymbol
Cbr1
resolver
genesymbol_syn
Cbr
resolver
uniprot
O08558
resolver
uniprot
Q3KR58
resolver
uniprot_entry
CBR1_RAT
resolver
uniprot_sec
O08558
resolver
uniprot_sec
Q3KR58
resolver
amino_acid_sequence
MSSDRPVALVTGANKGIGFAIVRDLCRKFLGDVVLTARDESRGHEAVKQLQTEGLSPRFHQLDIDNPQSIRALRDFLLQEYGGLNVLVNNAGIAFKVVDPTPFHIQAEVTMKTNFFGTQDVCKELLPIIKPQGRVVNVSSSVSLRALKSCSPELQQKFRSETITEEELVGLMNKFIEDAKKGVHAKEGWPNSAYGVTKIGVTVLSRIYARKLNEERREDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPGAEGPHGQFVQDKKVEPW
uniprot
proteins
ec_number
1.1.1.184
uniprot
proteins
ec_number
1.1.1.189
uniprot
proteins
ec_number
1.1.1.196
uniprot
proteins
ec_number
1.1.1.197
uniprot
proteins
ec_number
1.1.1.71
uniprot
proteins
function
FUNCTION: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics (PubMed:7705364, PubMed:8198567). Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (By similarity). {ECO:0000250|UniProtKB:P16152, ECO:0000250|UniProtKB:Q28960, ECO:0000269|PubMed:7705364, ECO:0000269|PubMed:8198567}.
uniprot
proteins
mass_dalton
30578
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7705364
uniprot
proteins
pubmed
8198567
uniprot
proteins
pubmed
9015353
uniprot
proteins
sequence_length
277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q28960}.
uniprot
proteins