KCNH6
entrez
81033
canonical
uniprot
Q9H252
canonical
ensembl
ENSG00000173826
resolver
ensp
ENSP00000318212
resolver
ensp
ENSP00000396900
resolver
ensp
ENSP00000463533
resolver
ensp
ENSP00000463830
resolver
ensp
ENSP00000583475
resolver
ensp
ENSP00000583476
resolver
genesymbol
KCNH6
resolver
genesymbol_syn
ERG2
resolver
hgnc
HGNC:18862
resolver
uniprot
B4DKC0
resolver
uniprot
B4DPJ3
resolver
uniprot
J9JID4
resolver
uniprot
Q9BRD7
resolver
uniprot_entry
B4DKC0_HUMAN
resolver
uniprot_entry
B4DPJ3_HUMAN
resolver
uniprot_entry
KCNH6_HUMAN
resolver
uniprot_sec
J9JID4
resolver
uniprot_sec
Q9BRD7
resolver
amino_acid_sequence
MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGGLHSSPRQAPGSQDHQGFFLSDNQSDAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRVSSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPSYGDLDDCSPKHRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICGPCFSSLPEHLGSVPKQLDFQRHGSDPGFAGSWGH
uniprot
proteins
function
FUNCTION: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Activates even more slowly than KCNH2. {ECO:0000250|UniProtKB:O54853}.
uniprot
proteins
mass_dalton
106425
uniprot
proteins
protein_family
H (Eag) (TC 1.A.1.20) subfamily
uniprot
proteins
protein_family
Kv11.2/KCNH6 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
12634931
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19139490
uniprot
proteins
sequence_length
958
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q12809}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12809}.
uniprot
proteins
transmembrane_region
TRANSMEM 262..282; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 299..319; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 341..361; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 371..391; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 399..419; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 491..511; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins