Slc25a47
entrez
299316
canonical
uniprot
Q6J329
canonical
ensembl
ENSRNOG00000003020
resolver
ensembl
ENSRNOG00055031670
resolver
ensembl
ENSRNOG00060026123
resolver
ensp
ENSRNOP00000097161
resolver
ensp
ENSRNOP00055045312
resolver
ensp
ENSRNOP00060037548
resolver
enst
ENSRNOT00000106027
resolver
enst
ENSRNOT00055054830
resolver
enst
ENSRNOT00060045241
resolver
genesymbol
Slc25a47
resolver
genesymbol_syn
Hdmcp
resolver
uniprot_entry
S2547_RAT
resolver
amino_acid_sequence
MDFVAGAIGGVCGVAVGYPLDTVKVKIQTEAKYTSIWHCVRDTYRQERLWGFYRGLSLPVCTVSLVSSVSFGTYHHCLAHICRFRYGSTDVKPTKADITLSGCASGLVRVFLTSPTEVAKVRLQTQAQSQTQQRRPSASWTSVAPALCPAPTACLEPRPKYSGPLHCLVTVAREEGLRGLYKGSSALLLREGHSFATYFLSYAVLSEWLTPAGQSQPDVLGVLVAGGCAGVLAWAVATPMDVIKSRLQADGQGQQRYRGLLHCVVTSVREEGPRVLFKGLALNCCRAFPVNMVVFVAYEAVLRLTQGLLT
uniprot
proteins
function
FUNCTION: Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q6IS41}.
uniprot
proteins
mass_dalton
33618
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
15322095
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q6IS41}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q6IS41}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 3..23; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 49..69; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 98..116; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 275..295; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins