Slc7a8
entrez
84551
canonical
uniprot
Q9WVR6
canonical
ensembl
ENSRNOG00000014311
resolver
ensembl
ENSRNOG00055012104
resolver
ensembl
ENSRNOG00060025856
resolver
ensembl
ENSRNOG00065031419
resolver
ensp
ENSRNOP00000019618
resolver
ensp
ENSRNOP00055016570
resolver
ensp
ENSRNOP00060037100
resolver
ensp
ENSRNOP00065044567
resolver
enst
ENSRNOT00000019618
resolver
enst
ENSRNOT00055020572
resolver
enst
ENSRNOT00060044749
resolver
enst
ENSRNOT00065054154
resolver
genesymbol
Slc7a8
resolver
genesymbol_syn
Lat2
resolver
genesymbol_syn
Lat4
resolver
uniprot_entry
LAT2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Leucine transport activity is inhibited by 2-amino-bicyclo-(2,2,1)-heptane-2-carboxylate (BCH), glycine, L-isomers of the neutral amino acids and histidine. {ECO:0000269|PubMed:10391916}.
uniprot
proteins
amino_acid_sequence
MEKGTRQRNNTAKNHPDRGSDTSPEAEASSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGVITAVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGVVQICKGEFFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANIAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCLSTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKISLLFPIIYLLFWAFLLIFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFNDFIESLTLVSQKMCVVVYPQEGDSGTEETIDDVEEQHKPIFQPTPVKDPDSEEQP
uniprot
proteins
function
FUNCTION: Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1 (PubMed:10391916). Functions as amino acid antiporter mediating the influx of extracellular essential amino acids mainly in exchange with the efflux of highly concentrated intracellular amino acids. Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter. This asymmetry allows SLC7A8 to regulate intracellular amino acid pools (mM concentrations) by exchange with external amino acids (uM concentration range), equilibrating the relative concentrations of different amino acids across the plasma membrane instead of mediating their net uptake. May play an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (By similarity). Imports the thyroid hormone diiodothyronine (T2) and to a smaller extent triiodothyronine (T3) but not rT 3 or thyroxine (T4) (By similarity). Mediates the uptake of L-DOPA (PubMed:15200428). May participate in auditory function (By similarity). Mediates the uptake of leucine, 3-iodo-L-tyrosine (MIT) and 3,5-diiodo-L-tyrosine (DIT) (By similarity). {ECO:0000250|UniProtKB:Q9QXW9, ECO:0000250|UniProtKB:Q9UHI5, ECO:0000269|PubMed:10391916, ECO:0000269|PubMed:15200428}.
uniprot
proteins
mass_dalton
58190
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
protein_family
L-type amino acid transporter (LAT) (TC 2.A.3.8) family
uniprot
proteins
pubmed
10391916
uniprot
proteins
pubmed
15200428
uniprot
proteins
pubmed
15980244
uniprot
proteins
pubmed
16027961
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
533
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9UHI5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UHI5}. Basolateral cell membrane {ECO:0000269|PubMed:16027961}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UHI5}. Note=Localized to the plasma membrane when coexpressed with SLC3A2/4F2hc. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi. {ECO:0000250|UniProtKB:Q9UHI5}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..66; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 75..96; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 118..150; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 159..179; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 183..211; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 232..253; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 267..288; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 314..339; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 366..383; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 388..409; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 425..447; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 448..467; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q9UHI5
uniprot
proteins