Aqp5
entrez
25241
canonical
uniprot
P47864
canonical
genesymbol
Aqp5
resolver
uniprot
Q2YDV0
resolver
uniprot
Q569C5
resolver
uniprot_entry
AQP5_RAT
resolver
uniprot_sec
Q2YDV0
resolver
uniprot_sec
Q569C5
resolver
amino_acid_sequence
MKKEVCSLAFFKAVFAEFLATLIFVFFGLGSALKWPSALPTILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISLLRAVFYVAAQLVGAIAGAGILYWLAPLNARGNLAVNALNNNTTPGKAMVVELILTFQLALCIFSSTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPSHWVFWVGPIVGAMLAAILYFYLLFPSSLSLHDRVAVVKGTYEPEEDWEDHREERKKTIELTAH
uniprot
proteins
function
FUNCTION: Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (PubMed:7530250, PubMed:8621489). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). {ECO:0000250|UniProtKB:Q9WTY4, ECO:0000269|PubMed:7530250, ECO:0000269|PubMed:8621489}.
uniprot
proteins
mass_dalton
28421
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7530250
uniprot
proteins
pubmed
8621489
uniprot
proteins
sequence_length
265
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9WTY4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55064}. Cell membrane {ECO:0000269|PubMed:7530250}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55064}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P55064}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55064}. Note=Hypotonicity increases location at the cell membrane. Phosphorylation decreases location at the cell membrane. {ECO:0000250|UniProtKB:P55064}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55064"; TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55064"; TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55064"; TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55064"; TRANSMEM 159..179; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55064"; TRANSMEM 204..224; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55064
uniprot
proteins