Cpb2
entrez
56373
canonical
uniprot
Q9JHH6
canonical
ensembl
ENSMUSG00000021999
resolver
ensp
ENSMUSP00000022576
resolver
enst
ENSMUST00000022576
resolver
genesymbol
Cpb2
resolver
genesymbol_syn
Tafi
resolver
uniprot
Q5EBI3
resolver
uniprot
Q9QZF0
resolver
uniprot_entry
CBPB2_MOUSE
resolver
uniprot_sec
Q5EBI3
resolver
uniprot_sec
Q9QZF0
resolver
activity_regulation
ACTIVITY REGULATION: TAFI/CPB2 is unique among carboxypeptidases in that it spontaneously inactivates with a short half-life, a property that is crucial for its role in controlling blood clot lysis. The zymogen is stabilized by interactions with the activation peptide. Release of the activation peptide increases a dynamic flap mobility and in time this leads to conformational changes that disrupt the catalytic site and expose a cryptic thrombin-cleavage site present at Arg-323 (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MKLHGLGILVAIILYEQHGFAFQSGQVLSALPRTSRQVQLLQNLTTTYEVVLWQPVTAEFIEKKKEVHFFVNASDVDSVKAHLNVSRIPFNVLMNNVEDLIEQQTFNDTVSPRASASYYEQYHSLNEIYSWIEVITEQHPDMLQKIYIGSSFEKYPLYVLKVSGKEQRIKNAIWIDCGIHAREWISPAFCLWFIGYVTQFHGKENLYTRLLRHVDFYIMPVMNVDGYDYTWKKNRMWRKNRSAHKNNRCVGTDLNRNFASKHWCEKGASSSSCSETYCGLYPESEPEVKAVADFLRRNIDHIKAYISMHSYSQQILFPYSYNRSKSKDHEELSLVASEAVRAIESINKNTRYTHGSGSESLYLAPGGSDDWIYDLGIKYSFTIELRDTGRYGFLLPERYIKPTCAEALAAISKIVWHVIRNT
uniprot
proteins
ec_number
3.4.17.20
uniprot
proteins
function
FUNCTION: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
uniprot
proteins
mass_dalton
48871
uniprot
proteins
protein_family
Peptidase M14 family
uniprot
proteins
pubmed
10739389
uniprot
proteins
pubmed
10878383
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16944957
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10739389}.
uniprot
proteins