Snap23
entrez
64630
canonical
uniprot
O70377
canonical
ensembl
ENSRNOG00000050552
resolver
ensembl
ENSRNOG00055002213
resolver
ensembl
ENSRNOG00060028428
resolver
ensembl
ENSRNOG00065025653
resolver
ensp
ENSRNOP00000064401
resolver
ensp
ENSRNOP00000091304
resolver
ensp
ENSRNOP00055002633
resolver
ensp
ENSRNOP00060041249
resolver
ensp
ENSRNOP00065036305
resolver
enst
ENSRNOT00000074392
resolver
enst
ENSRNOT00000096953
resolver
enst
ENSRNOT00055003527
resolver
enst
ENSRNOT00060049449
resolver
enst
ENSRNOT00065044224
resolver
genesymbol
Snap23
resolver
genesymbol_syn
AABR07053516.1
resolver
uniprot
A0JPL8
resolver
uniprot
M0R4V3
resolver
uniprot_entry
M0R4V3_RAT
resolver
uniprot_entry
SNP23_RAT
resolver
uniprot_sec
A0JPL8
resolver
amino_acid_sequence
MDDLSPEEIQLRAHQVTDESLESTRRILGLAIESQDAGIKTITMLDEQGEQLNRIEEGMDQINKDMREAEKTLTELNKCCGLCVCPCNRTKNFESGKNYKATWGDGGDSSPSNVVSKQPSRITNGQPQQTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKNMALDMGNEIDAQNQQIQKITEKADTNKNRIDIANTRAKKLIDS
uniprot
proteins
function
FUNCTION: SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (PubMed:14993220). SNAP23 is a t-SNARE (target-SNARE) that resides on target membrane and functions in the fusion of transport vesicles with the plasma membrane in immune cells. In macrophages, regulates the stimulus-dependent vesicular transport of TLR4 from recycling endosomes to the plasma membrane by cooperating with STX11 and thereby plays a critical role in the recognition of microbial components and the induction of innate and adaptive immunity. In skeletal muscle satellite cells, SNAP23 cooperates with its cognate SNAREs VAMP4 and STX11 to facilitate CD36 vesicular transport from endosomes to the plasma membrane, an essential step in muscle regeneration (By similarity). {ECO:0000250|UniProtKB:O00161, ECO:0000250|UniProtKB:O09044, ECO:0000269|PubMed:14993220}.
uniprot
proteins
mass_dalton
23235
uniprot
proteins
protein_family
SNAP-25 family
uniprot
proteins
pubmed
10051443
uniprot
proteins
pubmed
14993220
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O00161}; Lipid-anchor {ECO:0000250|UniProtKB:O00161}.
uniprot
proteins