Mtfp1
entrez
67900
canonical
uniprot
Q9CRB8
canonical
ensembl
ENSMUSG00000004748
resolver
ensp
ENSMUSP00000004868
resolver
enst
ENSMUST00000004868
resolver
genesymbol
Mtfp1
resolver
genesymbol_syn
Mtp18
resolver
uniprot
Q9CZX4
resolver
uniprot_entry
MTFP1_MOUSE
resolver
uniprot_sec
Q9CZX4
resolver
amino_acid_sequence
MSEQQRQGAERDLYRDTWVRYLGYANEVGEAFRSLVPAAVVWLSYGVSSSYVLADAIDKGKKAGEVPSPEAGRNTRMALAVVDTFVWQSLASVAIPGFTINRLCAASLYVLGTMTHWPPTVRKWTTTTLGLLAIPVIIHPIDRSVDFLLDSSLRKLYPSVEKPSTP
uniprot
proteins
function
FUNCTION: Plays a role in the regulation of mitochondrial morphology. Inhibits mitochondrial fusion by creating a non-fusogenic lipid environment which affects OPA1 oligomerization and its subsequent capacity to drive fusion. This prevents defective inner mitochondrial membrane (IMM) subdomains from fusing with other mitochondria, facilitating their segregation into small MTFP1-enriched mitochondria (SMEM) which are targeted for autophagic degradation. This IMM quality control mechanism controls mitochondrial DNA levels. {ECO:0000250|UniProtKB:Q9UDX5}.
uniprot
proteins
mass_dalton
18314
uniprot
proteins
protein_family
MTFP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
166
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9UDX5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UDX5}. Note=Assembles into discrete subdomains known as small MTFP1-enriched mitochondria (SMEM). {ECO:0000250|UniProtKB:Q9UDX5}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 78..98; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 129..149; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins