SRF
entrez
6722
canonical
uniprot
P11831
canonical
ensembl
ENSG00000112658
resolver
ensp
ENSP00000265354
resolver
enst
ENST00000265354
resolver
genesymbol
SRF
resolver
hgnc
HGNC:11291
resolver
uniprot
B4DU24
resolver
uniprot
Q5T648
resolver
uniprot_entry
B4DU24_HUMAN
resolver
uniprot_entry
SRF_HUMAN
resolver
uniprot_sec
Q5T648
resolver
amino_acid_sequence
MLPTQAGAAAALGRGSALGGSLNRTPTGRPGGGGGTRGANGGRVPGNGAGLGPGRLEREAAAAAATTPAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMEIGMVVGGPEASAAATGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATGFEETDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAIQVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMTSSVPTTVGGHMMYPSPHAVMYAPTSGLGDGSLTVLNAFSQAPSTMQVSHSQVQEPGGVPQVFLTASSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDTAHSTKSE
uniprot
proteins
function
FUNCTION: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. {ECO:0000250|UniProtKB:Q9JM73}.
uniprot
proteins
mass_dalton
51593
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKDC. {ECO:0000269|PubMed:1547771, ECO:0000269|PubMed:8375385, ECO:0000269|PubMed:8407951}.
uniprot
proteins
pubmed
14565952
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
1512232
uniprot
proteins
pubmed
1547771
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16054032
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17670796
uniprot
proteins
pubmed
18497331
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19350017
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25298399
uniprot
proteins
pubmed
3203386
uniprot
proteins
pubmed
7637780
uniprot
proteins
pubmed
8375385
uniprot
proteins
pubmed
8407951
uniprot
proteins
sequence_length
508
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:19350017}.
uniprot
proteins