Large2
entrez
228366
canonical
uniprot
Q5XPT3
canonical
ensembl
ENSMUSG00000040434
resolver
ensp
ENSMUSP00000064128
resolver
ensp
ENSMUSP00000088070
resolver
ensp
ENSMUSP00000106915
resolver
ensp
ENSMUSP00000135024
resolver
ensp
ENSMUSP00000135400
resolver
enst
ENSMUST00000111284
resolver
enst
ENSMUST00000176774
resolver
enst
ENSMUST00000176810
resolver
genesymbol
Large2
resolver
genesymbol_syn
Gyltl1b
resolver
uniprot
A2AHG6
resolver
uniprot
A2AHG9
resolver
uniprot
H3BKI1
resolver
uniprot
Q14AT0
resolver
uniprot
Q5XPT2
resolver
uniprot
Q8BJZ8
resolver
uniprot
Q8K253
resolver
uniprot_entry
A2AHG6_MOUSE
resolver
uniprot_entry
H3BKI1_MOUSE
resolver
uniprot_entry
LARG2_MOUSE
resolver
uniprot_entry
Q14AT0_MOUSE
resolver
uniprot_sec
A2AHG9
resolver
uniprot_sec
Q5XPT2
resolver
uniprot_sec
Q8BJZ8
resolver
uniprot_sec
Q8K253
resolver
amino_acid_sequence
MLPRGRPRAMGAAVLLLLLLLVVGFFLFGRDPDYGLGTTATLDEDPYRSRNLSASSPQLLLPPKCEMLHVAIVCAGYNSSREIITLTKSLLFYRKNPLHLHLITDAVARNILETLFRTWMVPAVVVSFYDAEELKPLVSWIPNKHYSGLYGLMKLVLPSILPPSLARVIVLDTDVTFSSDIVELWALFDHFSDKQVVGLVENQSDWYLGNLWKNHRPWPALGRGFNTGVILLWLDRLQQTGWEQMWKVTAKRELLTLMATSLADQDIFNAVIKEHPHLVHPLPCVWNVQLSDHTRAERCYLEAADLKVIHWNSPKKLRVKNKHAEFFRNLHLTFLGYDGKLLRRELFGCPNQFPPGAEQLQQALTQLDEEEPCFEFRQQQLTVHRVHITFLPHQPPPPQPHDVTLVAQLSMDRLQMLEALCRHWPGPMSLALYLTDEEAQQFLHFVETSPVLSMRKDVAYHVVYRDGPLYPVNQLRNVALAQALTPYVFLSDIDFLPAYSLYDYLRASIEQLELDSRRKTALVVPAFETLHYRFSFPNSKAELLTLLDAGSLHTFRYHEWPQGHSSTDYSRWREAQAPYSVQWSADYEPYVVVPRDCPRYDPRFVGFGWNKVAHIIELDAQEYEFLVLPEAFSIHLPHAPSLDISRFRSSPTYRNCLQALKEEFHQDLSRRYGSAALKYLTALQQARSRA
uniprot
proteins
ec_number
2.4.-.-
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.2.-
uniprot
proteins
function
FUNCTION: Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner (PubMed:15958417, PubMed:23125099, PubMed:23135544, PubMed:25138275). Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:23125099, PubMed:23135544, PubMed:25138275). Supports the maturation of DAG1 more effectively than LARGE1 (By similarity). In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (PubMed:27496765). {ECO:0000250|UniProtKB:Q8N3Y3, ECO:0000269|PubMed:15958417, ECO:0000269|PubMed:23125099, ECO:0000269|PubMed:23135544, ECO:0000269|PubMed:25138275, ECO:0000269|PubMed:27496765}.
uniprot
proteins
mass_dalton
79514
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:23125099, ECO:0000269|PubMed:23135544}.
uniprot
proteins
protein_family
Glycosyltransferase 49 family; Glycosyltransferase 8 family; Glycosyltransferase 8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15958417
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23125099
uniprot
proteins
pubmed
23135544
uniprot
proteins
pubmed
25138275
uniprot
proteins
pubmed
27496765
uniprot
proteins
sequence_length
690
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15958417}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins