Ackr1
entrez
13349
canonical
uniprot
Q9QUI6
canonical
ensembl
ENSMUSG00000037872
resolver
ensp
ENSMUSP00000045134
resolver
enst
ENSMUST00000038227
resolver
genesymbol
Ackr1
resolver
genesymbol_syn
Darc
resolver
genesymbol_syn
Dfy
resolver
genesymbol_syn
Fy
resolver
uniprot
A0A0R4J0J4
resolver
uniprot
O35970
resolver
uniprot
Q91VB6
resolver
uniprot
Q920X0
resolver
uniprot
Q920X1
resolver
uniprot
Q920X2
resolver
uniprot
Q920X3
resolver
uniprot_entry
A0A0R4J0J4_MOUSE
resolver
uniprot_entry
ACKR1_MOUSE
resolver
uniprot_sec
O35970
resolver
uniprot_sec
Q91VB6
resolver
uniprot_sec
Q920X0
resolver
uniprot_sec
Q920X1
resolver
uniprot_sec
Q920X2
resolver
uniprot_sec
Q920X3
resolver
amino_acid_sequence
MGNCLYPVETLSLDKNGTQFTFDSWNYSFEDNYSYELSSDYSLTPAAPCYSCNLLDRSSLPFFMLTSVLGMLASGSILFAILRPFFHWQICPSWPILAELAVGSALFSIAVPILAPGLHSAHSTALCNLGYWVWYTSAFAQALLIGCYACLNPRLNIGQLRGFTLGLSVGLWGAAALSGLPVALASDVYNGFCTFPSSRDMEALKYTHYAICFTIFTVLPLTLLAAKGLKIALSKGPGPWVSVLWIWFIFWWPHGMVLIFDALVRSKTVLLYTCQSQKILDAMLNVTEALSMLHCVATPLLLALFCHQTTRRSLSSLSLPTRQASQMDALAGKS
uniprot
proteins
function
FUNCTION: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity). {ECO:0000250}.; FUNCTION: (Microbial infection) Acts as a receptor for the malaria parasite Plasmodium yoelii in mature erythrocytes but not reticulocytes. {ECO:0000269|PubMed:11929753}.
uniprot
proteins
mass_dalton
36694
uniprot
proteins
protein_family
Atypical chemokine receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10520743
uniprot
proteins
pubmed
11929753
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9314499
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000250}. Recycling endosome {ECO:0000250}. Membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 62..82; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 128..151; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 206..226; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 243..263; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 286..306; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins