Trp53inp1
entrez
60599
canonical
uniprot
Q9QXE4
canonical
ensembl
ENSMUSG00000028211
resolver
ensp
ENSMUSP00000029865
resolver
genesymbol
Trp53inp1
resolver
genesymbol_syn
Sip
resolver
uniprot
Q3UQK9
resolver
uniprot
Q923I6
resolver
uniprot_entry
Q3UQK9_MOUSE
resolver
uniprot_entry
T53I1_MOUSE
resolver
uniprot_sec
Q923I6
resolver
amino_acid_sequence
MFQRLNKMFVGEVTTSSSQEPEFSEKEDDEWILVDFIDTCPGFSAEEEEEDEDIGEESSAEHTSVFSCLPASLECLTDTSDSCFLQFESCPMEESWFITPPPCFTAGGLTTIKVETSPMENLLIEHPSMSVYAVHNSCPGLSEASCGNDEYNSSGPRMEAQSEMGKHIHCCVAALAAQATFLEQPKSFRPSQWIKGHSERQSLNRNGLRRQNLTRDCHTRQMKHSGWVVHQPCPRQYNY
uniprot
proteins
function
FUNCTION: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. {ECO:0000269|PubMed:11557757, ECO:0000269|PubMed:16044147, ECO:0000269|PubMed:19118006, ECO:0000269|PubMed:21339733}.
uniprot
proteins
mass_dalton
26935
uniprot
proteins
pubmed
10630289
uniprot
proteins
pubmed
11557757
uniprot
proteins
pubmed
16044147
uniprot
proteins
pubmed
19118006
uniprot
proteins
pubmed
21339733
uniprot
proteins
sequence_length
239
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000269|PubMed:11557757}. Nucleus, PML body {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
uniprot
proteins