PTN
entrez
5764
canonical
uniprot
P21246
canonical
ensembl
ENSG00000105894
resolver
ensp
ENSP00000341170
resolver
ensp
ENSP00000514273
resolver
ensp
ENSP00000547411
resolver
ensp
ENSP00000547412
resolver
ensp
ENSP00000600466
resolver
ensp
ENSP00000600467
resolver
ensp
ENSP00000600468
resolver
ensp
ENSP00000612673
resolver
ensp
ENSP00000612674
resolver
ensp
ENSP00000612675
resolver
ensp
ENSP00000612676
resolver
ensp
ENSP00000612677
resolver
ensp
ENSP00000612678
resolver
ensp
ENSP00000612679
resolver
enst
ENST00000348225
resolver
enst
ENST00000699293
resolver
enst
ENST00000877352
resolver
enst
ENST00000877353
resolver
enst
ENST00000930407
resolver
enst
ENST00000930408
resolver
enst
ENST00000930409
resolver
enst
ENST00000942614
resolver
enst
ENST00000942615
resolver
enst
ENST00000942616
resolver
enst
ENST00000942617
resolver
enst
ENST00000942618
resolver
enst
ENST00000942619
resolver
enst
ENST00000942620
resolver
genesymbol
PTN
resolver
genesymbol_syn
HBNF1
resolver
genesymbol_syn
NEGF1
resolver
hgnc
HGNC:9630
resolver
uniprot
A0A8V8TNI1
resolver
uniprot
Q5U0B0
resolver
uniprot
Q6ICQ5
resolver
uniprot
Q9UCC6
resolver
uniprot_entry
A0A8V8TNI1_HUMAN
resolver
uniprot_entry
PTN_HUMAN
resolver
uniprot_sec
Q5U0B0
resolver
uniprot_sec
Q6ICQ5
resolver
uniprot_sec
Q9UCC6
resolver
amino_acid_sequence
MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSGDCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGSLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD
uniprot
proteins
function
FUNCTION: Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:11278720, PubMed:16814777, PubMed:19141530). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (PubMed:26896299, PubMed:27445335). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (PubMed:11278720, PubMed:1733956, PubMed:1768439, PubMed:19141530, PubMed:19442624, PubMed:27445335, PubMed:30667096). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK, CTNNB1 or AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:10706604, PubMed:16814777, PubMed:17681947, PubMed:27445335, PubMed:30667096). Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:27445335, PubMed:30667096). Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (PubMed:19141530). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (By similarity). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion (By similarity). Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (By similarity). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (PubMed:11278720). Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway (By similarity). Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration (By similarity). In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway (By similarity). {ECO:0000250|UniProtKB:P63089, ECO:0000250|UniProtKB:P63090, ECO:0000269|PubMed:10706604, ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:16814777, ECO:0000269|PubMed:1733956, ECO:0000269|PubMed:17681947, ECO:0000269|PubMed:1768439, ECO:0000269|PubMed:19141530, ECO:0000269|PubMed:19442624, ECO:0000269|PubMed:26896299, ECO:0000269|PubMed:27445335, ECO:0000269|PubMed:30667096}.
uniprot
proteins
mass_dalton
18942
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NEK6. {ECO:0000269|PubMed:20873783}.
uniprot
proteins
protein_family
Pleiotrophin family
uniprot
proteins
pubmed
10706604
uniprot
proteins
pubmed
11278720
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
1457401
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16814777
uniprot
proteins
pubmed
1701634
uniprot
proteins
pubmed
1733956
uniprot
proteins
pubmed
17681947
uniprot
proteins
pubmed
1768439
uniprot
proteins
pubmed
19141530
uniprot
proteins
pubmed
19442624
uniprot
proteins
pubmed
20873783
uniprot
proteins
pubmed
2270483
uniprot
proteins
pubmed
2388713
uniprot
proteins
pubmed
26896299
uniprot
proteins
pubmed
27445335
uniprot
proteins
pubmed
30667096
uniprot
proteins
pubmed
8241100
uniprot
proteins
pubmed
8484754
uniprot
proteins
pubmed
8484780
uniprot
proteins
pubmed
9299545
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1733956, ECO:0000269|PubMed:8241100}.
uniprot
proteins