Nlrp10
entrez
244202
canonical
uniprot
Q8CCN1
canonical
ensembl
ENSMUSG00000049709
resolver
ensp
ENSMUSP00000050252
resolver
enst
ENSMUST00000055745
resolver
genesymbol
Nlrp10
resolver
genesymbol_syn
Nalp10
resolver
genesymbol_syn
Pynod
resolver
uniprot
Q3V3Z6
resolver
uniprot
Q6JGS9
resolver
uniprot_entry
NAL10_MOUSE
resolver
uniprot_entry
Q3V3Z6_MOUSE
resolver
uniprot_entry
Q6JGS9_MOUSE
resolver
amino_acid_sequence
MALARANSPQEALLWALNDLEENSFKTLKFHLRDVTQFHLARGELESLSQVDLASKLISMYGAQEAVRVVSRSLLAMNLMELVDYLNQVCLNDYREIYREHVRCLEERQDWGVNSSHNKLLLMATSSSGGRRSPSCSDLEQELDPVDVETLFAPEAESYSTPPIVVMQGSAGTGKTTLVKKLVQDWSKGKLYPGQFDYVFYVSCREVVLLPKCDLPNLICWCCGDDQAPVTEILRQPGRLLFILDGYDELQKSSRAECVLHILMRRREVPCSLLITTRPPALQSLEPMLGERRHVLVLGFSEEERETYFSSCFTDKEQLKNALEFVQNNAVLYKACQVPGICWVVCSWLKKKMARGQEVSETPSNSTDIFTAYVSTFLPTDGNGDSSELTRHKVLKSLCSLAAEGMRHQRLLFEEEVLRKHGLDGPSLTAFLNCIDYRAGLGIKKFYSFRHISFQEFFYAMSFLVKEDQSQQGEATHKEVAKLVDPENHEEVTLSLQFLFDMLKTEGTLSLGLKFCFRIAPSVRQDLKHFKEQIEAIKYKRSWDLEFSLYDSKIKKLTQGIQMKDVILNVQHLDEKKSDKKKSVSVTSSFSSGKVQSPFLGNDKSTRKQKKASNGKSRGAEEPAPGVRNRRLASREKGHMEMNDKEDGGVEEQEDEEGQTLKKDGEMIDKMNG
uniprot
proteins
function
FUNCTION: Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (By similarity). Displays anti-inflammatory activity (By similarity). Required for immunity against C.albicans infection (PubMed:23071280). Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (By similarity). Contributes to T-cell-mediated inflammatory responses in the skin (PubMed:27221772). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (By similarity). Exhibits both ATPase and GTPase activities (By similarity). {ECO:0000250|UniProtKB:Q86W26, ECO:0000269|PubMed:23071280, ECO:0000269|PubMed:27221772}.
uniprot
proteins
mass_dalton
76367
uniprot
proteins
protein_family
NLRP family
uniprot
proteins
pubmed
15096476
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20393137
uniprot
proteins
pubmed
22538615
uniprot
proteins
pubmed
23071280
uniprot
proteins
pubmed
26605525
uniprot
proteins
pubmed
27221772
uniprot
proteins
sequence_length
673
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86W26}. Cell membrane {ECO:0000250|UniProtKB:Q86W26}; Peripheral membrane protein {ECO:0000305}. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection. {ECO:0000250|UniProtKB:Q86W26}.
uniprot
proteins