Hsd17b6
entrez
27400
canonical
uniprot
Q9R092
canonical
ensembl
ENSMUSG00000025396
resolver
ensp
ENSMUSP00000026462
resolver
ensp
ENSMUSP00000151556
resolver
ensp
ENSMUSP00000151661
resolver
ensp
ENSMUSP00000296363
resolver
ensp
ENSMUSP00000349833
resolver
ensp
ENSMUSP00000360519
resolver
enst
ENSMUST00000026462
resolver
enst
ENSMUST00000219183
resolver
enst
ENSMUST00000219447
resolver
genesymbol
Hsd17b6
resolver
genesymbol_syn
Gm182
resolver
genesymbol_syn
Hsd17b9
resolver
genesymbol_syn
Rdh8
resolver
uniprot_entry
H17B6_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by carbenoxolone and phenyl arsenoxide. {ECO:0000269|PubMed:10537158}.
uniprot
proteins
amino_acid_sequence
MWFYLVTLVGLYHLLRWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDRRGMRVLAACLTEKGAEELRNKTSDRLETVILDVTKTESIVAATQWVKERVGDRGLWGLVNNAGVLQPFAYIEWYRPEDYMPIFQVNLIGLTQVTISMLFLVKKARGRIVNVSSALGRVALFGGFYSCSKYGVEAFSDVLRHEVQDFGVKVSIIEPGSFKTEMTDAELTIERTKKVWEAAPEHIKESYGQQFFDDFCSTTKRELMKCSRNLSLVTDCMEHALTSTHPRTRYSAGWDAKFFFIPLSYLPASLVDYLLAISRGKPAQAA
uniprot
proteins
ec_number
1.1.1.105
uniprot
proteins
ec_number
1.1.1.209
uniprot
proteins
ec_number
1.1.1.239
uniprot
proteins
ec_number
1.1.1.53
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
function
FUNCTION: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). {ECO:0000269|PubMed:10537158}.
uniprot
proteins
mass_dalton
36103
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
10537158
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:10537158}; Peripheral membrane protein {ECO:0000269|PubMed:10537158}; Lumenal side {ECO:0000269|PubMed:10537158}. Early endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Lumenal side {ECO:0000305}.
uniprot
proteins