TBC1D18
entrez
9910
canonical
uniprot
B7ZAP0
canonical
uniprot
Q5R372
canonical
ensembl
ENSG00000152061
resolver
ensp
ENSP00000251507
resolver
ensp
ENSP00000281844
resolver
ensp
ENSP00000318603
resolver
ensp
ENSP00000350027
resolver
ensp
ENSP00000356660
resolver
ensp
ENSP00000356661
resolver
ensp
ENSP00000375916
resolver
ensp
ENSP00000420660
resolver
ensp
ENSP00000432490
resolver
ensp
ENSP00000434600
resolver
ensp
ENSP00000489605
resolver
ensp
ENSP00000507884
resolver
enst
ENST00000367688
resolver
enst
ENST00000367690
resolver
enst
ENST00000392064
resolver
enst
ENST00000681986
resolver
genesymbol
RABGAP1L
resolver
genesymbol
TBC1D18
resolver
genesymbol_syn
HHL
resolver
genesymbol_syn
KIAA0471
resolver
hgnc
HGNC:24663
resolver
uniprot
A0A0U1RRM5
resolver
uniprot
A0A804HKD7
resolver
uniprot
B7ZAA4
resolver
uniprot
F1LJ00
resolver
uniprot
F5H8L0
resolver
uniprot
O75059
resolver
uniprot
Q3ZTR8
resolver
uniprot
Q5R369
resolver
uniprot
Q8IVV0
resolver
uniprot
Q8N921
resolver
uniprot
Q8WV78
resolver
uniprot
Q9NSP8
resolver
uniprot
Q9UEL5
resolver
uniprot
Q9UQ19
resolver
uniprot
Q9UQP5
resolver
uniprot
Q9Y3L8
resolver
uniprot
Q9Y6Y5
resolver
uniprot
Q9Y6Y6
resolver
uniprot_entry
A0A0U1RRM5_HUMAN
resolver
uniprot_entry
A0A804HKD7_HUMAN
resolver
uniprot_entry
F1LJ00_HUMAN
resolver
uniprot_entry
F5H8L0_HUMAN
resolver
uniprot_entry
Q9UEL5_HUMAN
resolver
uniprot_entry
Q9Y3L8_HUMAN
resolver
uniprot_entry
RBG10_HUMAN
resolver
uniprot_entry
RBG1L_HUMAN
resolver
uniprot_sec
B7ZAA4
resolver
uniprot_sec
O75059
resolver
uniprot_sec
Q3ZTR8
resolver
uniprot_sec
Q5R369
resolver
uniprot_sec
Q8IVV0
resolver
uniprot_sec
Q8N921
resolver
uniprot_sec
Q8WV78
resolver
uniprot_sec
Q9NSP8
resolver
uniprot_sec
Q9UQ19
resolver
uniprot_sec
Q9UQP5
resolver
uniprot_sec
Q9Y6Y5
resolver
uniprot_sec
Q9Y6Y6
resolver
amino_acid_sequence
MEVRASLQKVSGSSDSVATMNSEEFVLVPQYADDNSTKHEEKPQLKIVSNGDEQLEKAMEEILRDSEKRPSSLLVDCQSSSEISDHSFGDIPASQTNKPSLQLILDPSNTEISTPRPSSPGGLPEEDSVLFNKLTYLGCMKVSSPRNEVEALRAMATMKSSSQYPFPVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTTESNCFAFTESSHGSEEFQIHVFSCEIKEAVSRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEVKEDDGKGNFSPVPKDRDKFYFKLKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDGRAYVITGMWNPNAPVFLALNEETPKDKQVYMTVAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHTNAGDAIYEVVSLQRESDKEEPVTPTSGGGPMSPQDDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQTMRESQLQQEDPMDRYKFVYL
uniprot
proteins
amino_acid_sequence
MIENSSWSMTFEERENRRLQEASMRLEQENDDLAHELVTSKIALRNDLDQAEDKADVLNKELLLTKQRLVETEEEKRKQEEETAQLKEVFRKQLEKAEYEIKKTTAIIAEYKQICSQLSTRLEKQQAASKEELEVVKGKMMACKHCSDIFSKEGALKLAATGREDQGIETDDEKDSLKKQLREMELELAQTKLQLVEAKCKIQELEHQRGALMNEIQAAKNSWFSKTLNSIKTATGTQPLQPAPVTQPPKEST
uniprot
proteins
disease_involvement
DISEASE: Leukemia, acute myelogenous (AML) [MIM:601626]: A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes. {ECO:0000269|PubMed:19184099}. Note=The gene represented in this entry may be involved in disease pathogenesis.; DISEASE: Note=A chromosomal aberration involving RABGAP1L has been found in bone marrow cells from a child with leukemia, acute myelogenous. Translocation der(Y)t(Y;1)(q12;q25). The breakpoint at 1q25 disrupts RABGAP1L. {ECO:0000269|PubMed:19184099}.
uniprot
proteins
function
FUNCTION: GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}.
uniprot
proteins
mass_dalton
29038
uniprot
proteins
mass_dalton
92513
uniprot
proteins
pubmed
12706106
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15367492
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16533400
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16923123
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19184099
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27718357
uniprot
proteins
pubmed
9455484
uniprot
proteins
sequence_length
253
uniprot
proteins
sequence_length
815
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250|UniProtKB:A6H6A9}. Early endosome {ECO:0000269|PubMed:16923123}. Golgi apparatus {ECO:0000269|PubMed:16923123}. Note=Colocalizes on endosomes partially with EEA1 (PubMed:16923123). Colocalizes and cotransports on motile vesicles with ANK2 (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}.
uniprot
proteins