SENP2
entrez
59343
canonical
uniprot
Q9HC62
canonical
ensembl
ENSG00000163904
resolver
ensp
ENSP00000296257
resolver
ensp
ENSP00000623533
resolver
genesymbol
SENP2
resolver
genesymbol_syn
KIAA1331
resolver
hgnc
HGNC:23116
resolver
uniprot
B4DQ42
resolver
uniprot
Q8IW97
resolver
uniprot
Q96SR2
resolver
uniprot
Q9P2L5
resolver
uniprot_entry
SENP2_HUMAN
resolver
uniprot_sec
B4DQ42
resolver
uniprot_sec
Q8IW97
resolver
uniprot_sec
Q96SR2
resolver
uniprot_sec
Q9P2L5
resolver
amino_acid_sequence
MYRWLVRILGTIFRFCDRSVPPARALLKRRRSDSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSSSCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
function
FUNCTION: Protease that catalyzes two essential functions in the SUMO pathway (PubMed:11896061, PubMed:12192048, PubMed:15296745, PubMed:20194620, PubMed:21965678). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15296745). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15296745, PubMed:20194620, PubMed:21965678). May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity). {ECO:0000250|UniProtKB:Q91ZX6, ECO:0000269|PubMed:11896061, ECO:0000269|PubMed:12192048, ECO:0000269|PubMed:15296745, ECO:0000269|PubMed:20194620, ECO:0000269|PubMed:21965678}.
uniprot
proteins
mass_dalton
67855
uniprot
proteins
mutagenesis
MUTAGEN 548; /note="C->S: Does not desumoylate CEBPB."; /evidence="ECO:0000269|PubMed:20194620"; MUTAGEN 576..577; /note="RK->LM: Does not desumoylate CEBPB."; /evidence="ECO:0000269|PubMed:20194620
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated; which leads to proteasomal degradation. {ECO:0000269|PubMed:16738331}.
uniprot
proteins
protein_family
Peptidase C48 family
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
11896061
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12192048
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15296745
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16738331
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20194620
uniprot
proteins
pubmed
21965678
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
589
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:12192048}. Nucleus membrane {ECO:0000269|PubMed:12192048}; Peripheral membrane protein {ECO:0000269|PubMed:12192048}; Nucleoplasmic side {ECO:0000269|PubMed:12192048}. Cytoplasm {ECO:0000269|PubMed:16738331}. Note=Shuttles between cytoplasm and nucleus. {ECO:0000269|PubMed:16738331}.
uniprot
proteins