Rnf112
entrez
24916
canonical
uniprot
O70418
canonical
ensembl
ENSRNOG00000002364
resolver
ensp
ENSRNOP00000003228
resolver
enst
ENSRNOT00000003228
resolver
genesymbol
Rnf112
resolver
genesymbol_syn
Bfp
resolver
genesymbol_syn
Zfp179
resolver
genesymbol_syn
Znf179
resolver
uniprot
A0A0H2UHA8
resolver
uniprot_entry
A0A0H2UHA8_RAT
resolver
uniprot_entry
RN112_RAT
resolver
amino_acid_sequence
MPRPVLSVTAFCHRLGKRESKRSFMGNSSNSWSHASFPKLELGLGQRPSPPRESPTCSICLERLREPISLDCGHDFCIRCFSTHRIPGCELPCCPECRKICKQKKGLRSLGERMKLLPQRPLPPALQETCAVRAERLLLVRINASGGLILRMGAINRCLKHPLARDTPVCLLAVLGEQHSGKSFLLDHLLRGLPGLESGDSTRPRAEGSLPGIRWGANGLTRGIWMWSHPFLLGKEGKKVAVFLVDTGDVMSPELSRETRVKLCALTMMLSSYQILNTSQELKDTDLGYLEMFVHVAEVMGKHYGMVPIQHLDLLVRDSSHHNKSGQGHVGDILQKLSGKYPKVQELLLGKRARCYLLPAPERQWVNKGQASPGGNTEDDFSHHFRAYISDVLSTAPQHAKSRCQGYWSEGRAMARGDRRLLTGQQLAQEIKNLSGWMGKSGPSFSSPDEMAAQLHDLRKVEAAKKEFEEYVRQQDIATKRIFSALRVLPDTMRNLLSTQKDAILARHGVALLCKEREQTLEALEAELQAEAKAFMDSYTMRFCGHLAAVGGAVGAGLMGLAGGVVGAGMAAAALAAEAGMVAAGAAVGATGAAVVGGGVGAGLAATVGCMEKEEDERVQGGDREPLLQEE
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density. {ECO:0000250|UniProtKB:Q96DY5}.
uniprot
proteins
mass_dalton
68646
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000250|UniProtKB:Q96DY5}.
uniprot
proteins
protein_family
GB1 subfamily
uniprot
proteins
protein_family
GB1/RHD3 GTPase family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
9367872
uniprot
proteins
sequence_length
631
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q96DY5}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000250|UniProtKB:Q96DY5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96DY5}. Cytoplasm {ECO:0000250|UniProtKB:Q96DY5}. Nucleus {ECO:0000250|UniProtKB:Q96DY5}. Nucleus, nuclear body {ECO:0000250|UniProtKB:Q96DY5}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q96DY5}. Endosome {ECO:0000250|UniProtKB:Q96DY5}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q96DY5}. Postsynaptic density {ECO:0000250|UniProtKB:Q96DY5}. Perikaryon {ECO:0000250|UniProtKB:Q96DY5}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q96DY5}. Note=Predominantly in the nucleus, but some amounts were also found in the cytoplasm. Oxidative stress stimulates its shuttling from the cytoplasm into the nucleus. Recruited to nuclear bodies via its interaction with ZBTB16. Localizes to the cell soma and neuritis and only slightly to the nucleus in the neurons of most brain areas. {ECO:0000250|UniProtKB:Q96DY5}.
uniprot
proteins
transmembrane_region
TRANSMEM 547..567; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 580..600; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins