Ptbp1
entrez
29497
canonical
uniprot
Q00438
canonical
ensembl
ENSRNOG00000010448
resolver
ensembl
ENSRNOG00055032803
resolver
ensembl
ENSRNOG00060025839
resolver
ensembl
ENSRNOG00065020312
resolver
ensp
ENSRNOP00000043256
resolver
ensp
ENSRNOP00000076206
resolver
ensp
ENSRNOP00000077281
resolver
enst
ENSRNOT00000093362
resolver
enst
ENSRNOT00000100764
resolver
genesymbol
Ptbp1
resolver
genesymbol_syn
Ptb
resolver
genesymbol_syn
Pybp
resolver
genesymbol_syn
Tbfii
resolver
uniprot
A0A1W2Q6A9
resolver
uniprot
A0A8I5Y0Z3
resolver
uniprot
F1LM18
resolver
uniprot
Q63568
resolver
uniprot
Q6P736
resolver
uniprot_entry
A0A1W2Q6A9_RAT
resolver
uniprot_entry
A0A8I5Y0Z3_RAT
resolver
uniprot_entry
PTBP1_RAT
resolver
uniprot_sec
F1LM18
resolver
uniprot_sec
Q63568
resolver
uniprot_sec
Q6P736
resolver
amino_acid_sequence
MDGIVPDIAVGTKRGSDELFSTCVSNGPFIMSSSASAANGNDSKKFKGDNRSTGVPSRVIHVRKLPSDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMSTEEAANTMVNYYTSVAPVLRGQPIYIQFSNHKELKTDSSPNQARAQAALQAVNSVQSGNLALAASAAAVDAGMAMAGQSPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTRPDLPSGDSQPSLDQTMAAAFGAPGIMSASPYAGAGFPPTFAIPQAAGLSVPNVHGALAPLAIPSAAAAAAAAGRIAIPGLAGAGNSVLLVSNLNPERVTPQSLFILFGVYGDVQRVKILFNKKENALVQMADGSQAQLAMSHLNGHKLHGKSVRITLSKHQSVQLPREGQEDQGLTKDYGSSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVSEDDLKSLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIELHNHDLGENHHLRVSFSKSTI
uniprot
proteins
function
FUNCTION: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. {ECO:0000250|UniProtKB:P26599}.
uniprot
proteins
mass_dalton
59366
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1681508
uniprot
proteins
sequence_length
556
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P26599}. Cytoplasm {ECO:0000250|UniProtKB:P26599}. Cytoplasm, P-body {ECO:0000250|UniProtKB:P26599}.
uniprot
proteins