Cs
entrez
12974
canonical
uniprot
Q9CZU6
canonical
ensembl
ENSMUSG00000005683
resolver
ensp
ENSMUSP00000005826
resolver
enst
ENSMUST00000005826
resolver
genesymbol
Cs
resolver
uniprot
Q3UDP3
resolver
uniprot_entry
CISY_MOUSE
resolver
uniprot_sec
Q3UDP3
resolver
amino_acid_sequence
MALLTAATRLLGAKNSSCLVLAARHASASSTNLKDVLSNLIPKEQARIKTFKQQHGKTVVGQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGYSIPECQKMLPKAKGGEEPLPEGLFWLLVTGQMPTEEQVSWLSREWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAITALNSESNFARAYAEGMNRAKYWELIYEDCMDLIAKLPCVAAKIYRNLYREGSSIGAIDSRLDWSHNFTNMLGYTDPQFTELMRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYSCQREFALKHLPKDPMFKLVAQLYKIVPNILLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTDGLMKFVDSK
uniprot
proteins
ec_number
2.3.3.1
uniprot
proteins
function
FUNCTION: Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate. {ECO:0000305}.
uniprot
proteins
mass_dalton
51737
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.
uniprot
proteins
post_translational_modification
PTM: Methylated. Trimethylation at Lys-395 by CSKMT decreases citrate synthase activity. {ECO:0000250|UniProtKB:O75390}.; PTM: In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1. {ECO:0000250|UniProtKB:O75390}.
uniprot
proteins
protein_family
Citrate synthase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P00889}.
uniprot
proteins