ADRA1D
entrez
146
canonical
uniprot
P25100
canonical
ensembl
ENSG00000171873
resolver
ensp
ENSP00000368766
resolver
enst
ENST00000379453
resolver
genesymbol
ADRA1D
resolver
genesymbol_syn
ADRA1A
resolver
hgnc
HGNC:280
resolver
uniprot
Q9NPY0
resolver
uniprot_entry
ADA1D_HUMAN
resolver
uniprot_sec
Q9NPY0
resolver
amino_acid_sequence
MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI
uniprot
proteins
function
FUNCTION: Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C (PubMed:7746284). ADRA1D binds the catecholamine ligands norepinephrine and epinephrine (PubMed:7815325, PubMed:8024574, PubMed:8183249). {ECO:0000269|PubMed:7746284, ECO:0000269|PubMed:7815325, ECO:0000269|PubMed:8024574, ECO:0000269|PubMed:8183249}.
uniprot
proteins
mass_dalton
60463
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Palmitoylation by ZDHHC21 may increase the expression of the receptor and regulate downstream signaling. {ECO:0000250|UniProtKB:P97714}.
uniprot
proteins
protein_family
ADRA1D sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
1656955
uniprot
proteins
pubmed
26460884
uniprot
proteins
pubmed
7746284
uniprot
proteins
pubmed
7815325
uniprot
proteins
pubmed
8024574
uniprot
proteins
pubmed
8183249
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 96..121; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 134..159; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 170..192; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 214..238; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 252..275; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 349..373; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 381..405; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins