Slc11a2
entrez
18174
canonical
uniprot
P49282
canonical
ensembl
ENSMUSG00000023030
resolver
ensp
ENSMUSP00000023774
resolver
ensp
ENSMUSP00000116463
resolver
ensp
ENSMUSP00000287030
resolver
genesymbol
Slc11a2
resolver
genesymbol_syn
Dct1
resolver
genesymbol_syn
Dmt1
resolver
genesymbol_syn
Nramp2
resolver
uniprot
O54903
resolver
uniprot
Q3UFV5
resolver
uniprot
Q8BJL2
resolver
uniprot
Q8BWV3
resolver
uniprot
Q8CFA0
resolver
uniprot
Q8VCU6
resolver
uniprot_entry
NRAM2_MOUSE
resolver
uniprot_sec
O54903
resolver
uniprot_sec
Q3UFV5
resolver
uniprot_sec
Q8BJL2
resolver
uniprot_sec
Q8BWV3
resolver
uniprot_sec
Q8CFA0
resolver
uniprot_sec
Q8VCU6
resolver
amino_acid_sequence
MVLDPKEKMPDDGASGDHGDSASLGAINPAYSNSSLPHSTGDSEEPFTTYFDEKIPIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWVLLLATIVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRIILWLMVELAIIGSDMQEVIGSAIAINLLSAGRVPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYITVKPSQSQVLRGMFVPSCPGCRTPQVEQAVGIVGAVIMPHNMYLHSALVKSRQVNRANKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFEKTNKQVVEVCKNNSSPHADLFPSDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVILTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSEFSNGIGWRIAGGILVLIVCSINMYFVVVYVQELGHVALYVVAAVVSVAYLTFVFYLGWQCLIALGLSFLDCGRSYRLGLTAQPELYLLNTVDADSVVSR
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Slc11a2 are the cause of microcytic anemia (mk). Homozygous mk/mk mice have hypochromic microcytic anemia due to severe defects in intestinal iron absorption and erythroid iron utilization.
uniprot
proteins
function
FUNCTION: Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:16475818). Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (By similarity) (PubMed:16475818). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (PubMed:11739192). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (By similarity). Can mediate uncoupled fluxes of either protons or metal ions. {ECO:0000250|UniProtKB:O54902, ECO:0000250|UniProtKB:P49281, ECO:0000269|PubMed:11739192, ECO:0000269|PubMed:16475818}.
uniprot
proteins
mass_dalton
62368
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by WWP2. {ECO:0000269|PubMed:18776082}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:P49281}.
uniprot
proteins
protein_family
NRAMP (TC 2.A.55) family
uniprot
proteins
pubmed
10361139
uniprot
proteins
pubmed
11739192
uniprot
proteins
pubmed
12209011
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15849611
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16475818
uniprot
proteins
pubmed
17293870
uniprot
proteins
pubmed
18776082
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27462458
uniprot
proteins
pubmed
7789986
uniprot
proteins
pubmed
9241278
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18776082}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:16475818, ECO:0000269|PubMed:18776082}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:16475818}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:16475818}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18776082}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:18776082}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:16475818}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:16475818}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:16475818}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P49281}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P49281}; Multi-pass membrane protein {ECO:0000255}. Extracellular vesicle membrane {ECO:0000269|PubMed:27462458}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 76..92; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 104..118; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 148..168; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 185..199; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 207..222; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 253..268; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 298..314; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 377..393; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 408..424; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 438..454; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 478..499; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 505..525; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P49279
uniprot
proteins