Ofd1
entrez
237222
canonical
uniprot
Q80Z25
canonical
ensembl
ENSMUSG00000040586
resolver
ensp
ENSMUSP00000041744
resolver
enst
ENSMUST00000049501
resolver
genesymbol
Ofd1
resolver
uniprot
A2AEG2
resolver
uniprot
Q3URP3
resolver
uniprot_entry
A2AEG2_MOUSE
resolver
uniprot_entry
OFD1_MOUSE
resolver
uniprot_entry
Q3URP3_MOUSE
resolver
amino_acid_sequence
MAQSNMPHKSDVLSQDELRKKLYQTFKDRGVLDTLQTQLRNQLIHELMHPVLSGEVKPPSISVEGSALLIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKIFTMQDLLQLIRINPSSSLYKSLISGFDKENKKGFLMSFLKELAEYYQAKESCDAETQTSTTFPSQVSLAEKFQLIDAQFADGFPHRSKLESLETKLNEYKKEVQHQLQVEMCHKLKYFREAEITKVKMEERRKYEKELAEFQNEFERTCQAKNEALISQEKNSLERIKKHREMESKEIYAQRQLLLNDIALLRGREAELKERIETFELTQKLQEEKIKSEAEALERREQNLKNIEDTYDQKLKTELLKYQLELKDDYITRTNKLLEEERKNKEKTIHLQEELTVINSKKEELSKSVKHMKEVELELESVKAQFLAISKQNHLLNEKVREMSDYSQLKEEKVELQAQNKLLKLQLEETRNENLRLLDRITQPPPELVIFQKELQKTEKAMELEHKDFETHRQALEKQLQSEIENSAQLRTQIAEYDASVKRLTVQVAELKSQLKQTQIALENEVYRNPKHSLIHSLSGLLLSGKMAPHSEDKSGDFLNVPLEQNKVIAGAVMSRVPPYVNTATEASSPESDFEFIASSTKAKVRELEQEAERLEKAFRTYYQRATQNPSTSPQPAKSPPSVNSVAALRSIASSSMDRPVSAEDRVVSEQPLGDMLKEEMSDMSKAFMGSVVSRPRRTSSSTRLSSTPHPKSRRSLDNEMYLEGLGRLHMTSSSPLLDRVSASPAASPSPCPERTAQASPVPSRHSFSGLPEQNACLYQRQTETQDKSELSNVDKQSLKDEKFEPPFRWNKTEQFEAEGLHPAGDMPGIDFAVATQSSRLISYDYPSAVQSQTGEQDEQELWELHMKERRQREEQRHNERQEALERERRELGKLEQERRMIEESLKMEMEEELEKSVQDQKDKSAHCENTLEKYMKIIQQRQEESNADKSSKKSGKECSLVDMMMPSDKDESSPGFSHEEPDDMW
uniprot
proteins
function
FUNCTION: Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation. {ECO:0000269|PubMed:18084282, ECO:0000269|PubMed:20230748}.
uniprot
proteins
mass_dalton
117345
uniprot
proteins
mutagenesis
MUTAGEN 73; /note="S->A: Induces centriole elongation. Impaired IFT88 recruitment. Impaired ciliogenesis."; /evidence="ECO:0000269|PubMed:20230748"; MUTAGEN 78; /note="A->T: Induces centriole elongation. Impaired CEP164 and IFT88 recruitment. Impaired ciliogenesis."; /evidence="ECO:0000269|PubMed:20230748"; MUTAGEN 137; /note="G->S: Induces centriole elongation. Reduced ciliogenesis."; /evidence="ECO:0000269|PubMed:20230748"; MUTAGEN 358..360; /note="KDD->FSY: Shortened centrioles. Reduced ciliogenesis."; /evidence="ECO:0000269|PubMed:20230748"; MUTAGEN 435; /note="S->R: Induces centriole elongation. Impaired IFT88 recruitment. Reduced ciliogenesis."; /evidence="ECO:0000269|PubMed:20230748
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation at Ser-737, by the cAMP-dependent protein kinase PKA, triggers ubiquitination and proteasomal degradation of OFD1. Also increases its interaction with TBC1D31 and regulates its function in ciliogenesis. {ECO:0000250|UniProtKB:O75665}.; PTM: Ubiquitinated by PJA2, upon phosphorylation at Ser-737 by PKA, leads to the proteasomal degradation of OFD1. {ECO:0000250|UniProtKB:O75665}.
uniprot
proteins
protein_family
OFD1 family
uniprot
proteins
pubmed
12782125
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16311594
uniprot
proteins
pubmed
18084282
uniprot
proteins
pubmed
20230748
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24089205
uniprot
proteins
pubmed
26643951
uniprot
proteins
sequence_length
1017
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:20230748}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24089205}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:O75665}. Nucleus {ECO:0000250|UniProtKB:O75665}. Note=Localizes to centriole distal ends and to centriolar satellites (PubMed:20230748, PubMed:24089205). Localization to centrioles and pericentriolar satellites may be mediated by KIAA0753/OFIP (By similarity). {ECO:0000250|UniProtKB:O75665}.
uniprot
proteins