Slc9a8
entrez
77031
canonical
uniprot
Q8R4D1
canonical
ensembl
ENSMUSG00000039463
resolver
ensp
ENSMUSP00000044185
resolver
ensp
ENSMUSP00000104841
resolver
ensp
ENSMUSP00000233261
resolver
enst
ENSMUST00000109218
resolver
genesymbol
Slc9a8
resolver
genesymbol_syn
Nhe8
resolver
uniprot
A2A464
resolver
uniprot
A2A465
resolver
uniprot
Q3UPR4
resolver
uniprot
Q5WA59
resolver
uniprot
Q8BIH8
resolver
uniprot
Q8BJ27
resolver
uniprot_entry
A2A464_MOUSE
resolver
uniprot_entry
SL9A8_MOUSE
resolver
uniprot_sec
A2A465
resolver
uniprot_sec
Q3UPR4
resolver
uniprot_sec
Q5WA59
resolver
uniprot_sec
Q8BIH8
resolver
uniprot_sec
Q8BJ27
resolver
amino_acid_sequence
MAEEEFSNTTHETFNFTLHTTLGVTTKLVLPTPAKPILPVQTGEQAQQEEQSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKVIEFKKLANWKEEEMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRKHMSDVSGWQTFSQALGYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLGLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLVDIEDARARRRSKKDVNLSKTEKMGNAIESEHLSELTEEEYEAHYIRQQDLKGFMWLDAKYLNPFFTRRLTQEDLHHGRIQMKSLTNKWYEEVRQGPSGSEDDEQELF
uniprot
proteins
function
FUNCTION: Na(+)/H(+) antiporter. Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Acts as an Na(+)/H(+) exchanger in the trans-Golgi. Contributes to the regulation of pH regulation of Golgi apparatus, and consequently, in protein trafficking and endosomal morphology (By similarity). Plays a crucial role in germ cells in acrosome biogenesis and sperm development, probably by playing a role in the fusion of the Golgi-derived vesicles that form the acrosomal cap (PubMed:25472965, PubMed:28476888). Can also be active at the cell surface of specialized cells. In the small intestine, plays a major physiological role in transepithelial absorption of Na(+). Regulates intracellular pH homeostasis of intestinal epithelial cells (By similarity). Acts as an important regulator of mucosal integrity in the intestine and in the stomach, could mediate the pH fluctuation necessary for mucin exocytosis or assist membrane trafficking of other proteins (PubMed:23220221, PubMed:23657568, PubMed:26505975). Plays a role in photoreceptor survival and in the maintenance of intracellular pH homeostasis in retinal pigment epithelium (RPE cells) (PubMed:25377091, PubMed:29958869). {ECO:0000250|UniProtKB:Q9Y2E8, ECO:0000269|PubMed:23220221, ECO:0000269|PubMed:23657568, ECO:0000269|PubMed:25377091, ECO:0000269|PubMed:25472965, ECO:0000269|PubMed:26505975, ECO:0000269|PubMed:28476888, ECO:0000269|PubMed:29958869}.
uniprot
proteins
mass_dalton
64737
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
12409279
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15522866
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18209477
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22575219
uniprot
proteins
pubmed
23220221
uniprot
proteins
pubmed
23657568
uniprot
proteins
pubmed
25377091
uniprot
proteins
pubmed
25472965
uniprot
proteins
pubmed
26505975
uniprot
proteins
pubmed
28476888
uniprot
proteins
pubmed
29958869
uniprot
proteins
sequence_length
576
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Y2E8}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9Y2E8}; Multi-pass membrane protein {ECO:0000255}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:Q9Y2E8}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:23220221}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:28476888}. Note=Mainly localized to the mid- to trans-Golgi compartments but a proportion is also localized to multivesicular bodies (By similarity). Localized at the apical membrane in the gastrointestinal tract (By similarity). Recruitment to the plasma membrane upon acid stimulation (By similarity). {ECO:0000250|UniProtKB:Q4L208, ECO:0000250|UniProtKB:Q9Y2E8}.
uniprot
proteins
transmembrane_region
TRANSMEM 55..75; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 151..171; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 256..276; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 306..326; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 349..369; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 374..394; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 412..432; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 446..466; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins