Sdc4
entrez
20971
canonical
uniprot
O35988
canonical
ensembl
ENSMUSG00000017009
resolver
ensp
ENSMUSP00000017153
resolver
enst
ENSMUST00000017153
resolver
genesymbol
Sdc4
resolver
uniprot
Q3U5S6
resolver
uniprot_entry
Q3U5S6_MOUSE
resolver
uniprot_entry
SDC4_MOUSE
resolver
amino_acid_sequence
MAPACLLAPLLLLLLGGFPLVPGESIRETEVIDPQDLLEGRYFSGALPDDEDAGGSDDFELSGSGDLDDTEEPRPFPEVIEPLVPLDNHIPENAQPGIRVPSEPKELEENEVIPKRAPSDVGDDMSNKVSMSSTAQGSNIFERTEVLAALIVGGVVGILFAVFLILLLVYRMKKKDEGSYDLGKKPIYKKAPTNEFYA
uniprot
proteins
function
FUNCTION: Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP. {ECO:0000250|UniProtKB:P31431}.
uniprot
proteins
mass_dalton
21482
uniprot
proteins
post_translational_modification
PTM: Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. {ECO:0000269|PubMed:10684261}.; PTM: O-glycosylated; contains both chondroitin sulfate and heparan sulfate. Ser-44, Ser-62 and Ser-64 can all be modified by either chondroitin sulfate or heparan sulfate, and the protein exists in forms that contain only chondroitin sulfate, only heparan sulfate and both chondroitin sulfate and heparan sulfate. {ECO:0000250|UniProtKB:P34901}.
uniprot
proteins
protein_family
Syndecan proteoglycan family
uniprot
proteins
pubmed
10684261
uniprot
proteins
pubmed
10911369
uniprot
proteins
pubmed
11805099
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15694365
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9276666
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:10684261}. Note=Shedding of the ectodomain produces a soluble form. {ECO:0000269|PubMed:10684261}.
uniprot
proteins
transmembrane_region
TRANSMEM 146..170; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins