Caprin1
entrez
362173
canonical
uniprot
Q5M9G3
canonical
ensembl
ENSRNOG00000009152
resolver
ensembl
ENSRNOG00055000223
resolver
ensembl
ENSRNOG00060001856
resolver
ensembl
ENSRNOG00065017419
resolver
ensp
ENSRNOP00000012428
resolver
ensp
ENSRNOP00000102792
resolver
ensp
ENSRNOP00055000259
resolver
ensp
ENSRNOP00060001873
resolver
ensp
ENSRNOP00065023059
resolver
enst
ENSRNOT00000143989
resolver
enst
ENSRNOT00055000373
resolver
enst
ENSRNOT00060002863
resolver
enst
ENSRNOT00065029097
resolver
genesymbol
Caprin1
resolver
genesymbol_syn
Gpiap1
resolver
genesymbol_syn
Rng105
resolver
uniprot
A9ZSZ9
resolver
uniprot
Q6YF16
resolver
uniprot_entry
CAPR1_RAT
resolver
uniprot_sec
A9ZSZ9
resolver
uniprot_sec
Q6YF16
resolver
activity_regulation
ACTIVITY REGULATION: Ability to mediate liquid-liquid phase separation is regulated by ATP: moderate concentrations of ATP enhance phase separation, whereas high concentrations of ATP lead to inhibition of phase separation. {ECO:0000250|UniProtKB:Q14444}.
uniprot
proteins
amino_acid_sequence
MPSATSHSGSGSKSSGPPPPSGSSGSEAAAGAAAPASQHPATGTGAVQTEAMKQILGVIDKKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMALSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLGDDDVRTDLKQGLSGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHASIHLWDLLEGKEKPVCGTTYKALKEIVERVFQSNYFDSTHNHQNGLCEEEEAASAPIVEDQVAEAEPEPTEEYTEQSEVESTEYVNRQFMAETQFSSGEKEQVDEWAVETVEVVNSLQQQPQAASPSVPEPHSLTPVAQSDPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPTQNMDMPQLVCPQVHSESRLAQSNQVPVQPEATQVPLVSSTSEGYTASQPLYQPSHAAEQRPQKEPIDQIQATISLNTEQTTASSSLPAASQPQVFQAGASKPLHSSGINVNAAPFQSMQTVFNMNAPVPPVNEPETLKQQSQYQASYNQSFSSQPHQVEQTELQQDQLQTVVGTYHGSQDQPHQVPGNHQQPPQQSTGFPRSSQPYYNSRGVSRGGSRGARGLMNGYRGPANGFRGGYDGYRSSFSNTPNSGYTQSQFNAPRDYSGYQRDGYQQNFKRGSGQSGPRGAPRGRGGPPRPNRGMPQMNTQQVN
uniprot
proteins
function
FUNCTION: mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:15858068, PubMed:20516077). Plays an essential role in cytoplasmic stress granule formation (By similarity). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (By similarity). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (By similarity). Binds directly and selectively to MYC and CCND2 mRNAs (By similarity). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (By similarity). {ECO:0000250|UniProtKB:Q14444, ECO:0000269|PubMed:15858068, ECO:0000269|PubMed:20516077}.
uniprot
proteins
mass_dalton
78121
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylation by EPHA4 promotes interaction with FMR1 and liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that concentrates mRNAs with associated regulatory factors. {ECO:0000250|UniProtKB:Q14444}.; PTM: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. O-glycosylation by OGT inhibit ability to undergo liquid-liquid phase separation (LLPS). {ECO:0000250|UniProtKB:Q14444}.
uniprot
proteins
protein_family
Caprin family
uniprot
proteins
pubmed
14565619
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15858068
uniprot
proteins
pubmed
20516077
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
707
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q14444}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q14444}. Cell projection, dendrite {ECO:0000269|PubMed:15858068, ECO:0000269|PubMed:20516077}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q14444}. Note=Mediates formation and localizes to cytoplasmic ribonucleoprotein membraneless compartments. Associated with RNA granules. At the leading edge of migrating fibroblasts, colocalizes with DDX3X. {ECO:0000250|UniProtKB:Q14444}.
uniprot
proteins