Psen2
entrez
81751
canonical
uniprot
O88777
canonical
ensembl
ENSRNOG00000002879
resolver
ensembl
ENSRNOG00055012376
resolver
ensembl
ENSRNOG00060006926
resolver
ensembl
ENSRNOG00065023676
resolver
ensp
ENSRNOP00000049605
resolver
ensp
ENSRNOP00055017047
resolver
ensp
ENSRNOP00060008464
resolver
ensp
ENSRNOP00065033042
resolver
enst
ENSRNOT00000040203
resolver
enst
ENSRNOT00055021080
resolver
enst
ENSRNOT00060011338
resolver
enst
ENSRNOT00065040551
resolver
genesymbol
Psen2
resolver
genesymbol_syn
Ps2
resolver
genesymbol_syn
Psnl2
resolver
uniprot
O08947
resolver
uniprot
O35546
resolver
uniprot_entry
PSN2_RAT
resolver
uniprot_sec
O08947
resolver
uniprot_sec
O35546
resolver
amino_acid_sequence
MLTFMASDSEEEVCDERTSLMSAESPTSRSCQDSRPGPEDGENTAQWRSQENEDDCEEDPDHYACSGVPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVFKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEAFEAPQPGYPGEEPEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWSTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI
uniprot
proteins
ec_number
3.4.23.-
uniprot
proteins
function
FUNCTION: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (By similarity). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369). {ECO:0000250|UniProtKB:P49810, ECO:0000269|PubMed:21285369}.
uniprot
proteins
mass_dalton
50051
uniprot
proteins
post_translational_modification
PTM: Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments. {ECO:0000250|UniProtKB:P49810}.; PTM: Phosphorylated on serine residues. Phosphorylation at Ser-19 affects PSEN2 sorting. {ECO:0000250|UniProtKB:P49810}.
uniprot
proteins
protein_family
Peptidase A22A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21285369
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9332390
uniprot
proteins
pubmed
9545577
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P49810}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P49810}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:P49810}. Lysosome membrane {ECO:0000250|UniProtKB:P49810}. Note=Late endosome/lysosome localization is dependent of the phosphorylation-mediated interaction with the AP1G1 (By similarity). Also highly enriched in mitochondria-associated endoplasmic reticulum membrane contact site (By similarity). {ECO:0000250|UniProtKB:P49810, ECO:0000250|UniProtKB:Q61144}.
uniprot
proteins
transmembrane_region
TRANSMEM 88..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 250..270; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 359..379; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 389..409; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins