Ttll3
entrez
101100
canonical
uniprot
A4Q9E5
canonical
ensembl
ENSMUSG00000030276
resolver
ensp
ENSMUSP00000032414
resolver
ensp
ENSMUSP00000145049
resolver
genesymbol
Ttll3
resolver
uniprot
Q8BV51
resolver
uniprot
Q8C0Y7
resolver
uniprot
Q8VDS2
resolver
uniprot_entry
TTLL3_MOUSE
resolver
uniprot_sec
Q8BV51
resolver
uniprot_sec
Q8C0Y7
resolver
uniprot_sec
Q8VDS2
resolver
amino_acid_sequence
MQGVSSALLLSAGQLGPGAAWYRQEGSSECSWLRRSQPSELRTNFSSRWPWPRNSESRRSERLQWPGPASAKPEVASCGDSRRDYSSLPARHLSSARESSMPGALGTVNPQPVRTLVPPTLDEPLPDALRPPDDSLLLWRGLTKGPNHMGRLRNAKIHVERAVKQKKIFMIHGRYPVIRCLLRQRGWVEKKMVHPPGTALPAPQKDLDSSMLGDSDATEDEDEEENEMFRESQLLDLDGFLEFDDLDGIHALMSRMVRNETPYLIWTTRRDVLDCRFLSKDQMINHYARAGSFTTKVGLCLNLRNLPWFDEADADSFFPRCYRLGAEDDKKAFIEDFWLTAARNVLKLVVKLEEKSQSISIQAREEEAPEDTQPKKQEKKLVTVSSDFVDEALSACQEHLSSIAHKDIDKDPNSPLYLSPDDWSQFLQRYYQIVHEGAELRYLEVQVQRCEDILQQLQNVVPQLDMEGDRNIWIVKPGAKSRGRGIMCMNRLDEMLKLVDCNPMLMKDGKWIVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKNLDNSVHLCNNSIQRHLEASCHRHPMLPPDNMWSSQRFQAHLQEVDAPKAWSSVIVPGMKAAVIHALQTSQDNVQCRKASFELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQADTLRVVIDRRLDRSCDTGAFELIYKQPAVEVPQYVGIRLLVEGSTIKKPVPVGHRRTGVRSSLPHLLTQQGSGESKDSGSPTHRSASRKNARAESLEHTEKPEPAAVASVSGKGKKAPFHFPSLHSKAWLPSPRVHRPQGRVLRLQHDQLVGSKALSTTGKALMTLPTAKVLMSFPPHPDLKLAPSMLKPGKVGFELCCTTWRVVLSGGIGEEGHRQRAAPRPSSAPGKGLSSTEPCSKTET
uniprot
proteins
ec_number
6.3.2.-
uniprot
proteins
function
FUNCTION: Monoglycylase which modifies alpha- and beta-tubulin, adding a single glycine on the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of tubulin (PubMed:19524510). Not involved in elongation step of the polyglycylation reaction (PubMed:19524510). Preferentially glycylates a beta-tail peptide over the alpha-tail, although shifts its preference toward alpha-tail as beta-tail glutamylation increases (By similarity). Competes with polyglutamylases for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions (PubMed:33414192). Together with TTLL8, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance (PubMed:23897886, PubMed:25180231). Involved in microtubule glycylation of primary cilia in colon which controls cell proliferation of epithelial cells and plays an essential role in colon cancer development (PubMed:25180231). Together with TTLL8, glycylates sperm flagella which regulates axonemal dynein motor activity, thereby controlling flagellar beat, directional sperm swimming and male fertility (PubMed:33414192). {ECO:0000250|UniProtKB:B2GUB3, ECO:0000269|PubMed:19524510, ECO:0000269|PubMed:23897886, ECO:0000269|PubMed:25180231, ECO:0000269|PubMed:33414192}.
uniprot
proteins
mass_dalton
104428
uniprot
proteins
mutagenesis
MUTAGEN 647; /note="G->S: Loss of tubulin monoglycylation activity."; /evidence="ECO:0000269|PubMed:19524510"; MUTAGEN 662; /note="E->G: Loss of tubulin monoglycylation activity."; /evidence="ECO:0000269|PubMed:19524510"; MUTAGEN 669; /note="M->I: Loss of tubulin monoglycylation activity."; /evidence="ECO:0000269|PubMed:19524510
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17499049
uniprot
proteins
pubmed
19524510
uniprot
proteins
pubmed
23897886
uniprot
proteins
pubmed
25180231
uniprot
proteins
pubmed
33414192
uniprot
proteins
sequence_length
927
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19524510}. Cell projection, cilium {ECO:0000305|PubMed:19524510}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305|PubMed:19524510}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000305|PubMed:33414192}.
uniprot
proteins