FXYD7
entrez
53822
canonical
uniprot
P58549
canonical
ensembl
ENSG00000221946
resolver
ensp
ENSP00000270310
resolver
enst
ENST00000270310
resolver
genesymbol
FXYD7
resolver
hgnc
HGNC:4034
resolver
uniprot_entry
FXYD7_HUMAN
resolver
amino_acid_sequence
MATPTQTPTKAPEEPDPFYYDYNTVQTVGMTLATILFLLGILIVISKKVKCRKADSRSESPTCKSCKSELPSSAPGGGGV
uniprot
proteins
function
FUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed:33231612). Reduces the apparent affinity for external K(+), an effect that depends on the presence of external Na(+) and voltage (PubMed:33231612). Increases the apparent affinity for intracellular Na(+) (PubMed:33231612). {ECO:0000269|PubMed:33231612}.
uniprot
proteins
mass_dalton
8524
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; required for stabilization and translocation to the plasma membrane. {ECO:0000250|UniProtKB:P59648}.
uniprot
proteins
protein_family
FXYD family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
33231612
uniprot
proteins
sequence_length
80
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P59648}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P59648}. Note=Able to translocate to the plasma membrane independent of its association with NKA (in vitro). {ECO:0000250|UniProtKB:P59649}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..46; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins