Smad1
entrez
17125
canonical
uniprot
P70340
canonical
ensembl
ENSMUSG00000031681
resolver
ensp
ENSMUSP00000071035
resolver
ensp
ENSMUSP00000183668
resolver
enst
ENSMUST00000066091
resolver
genesymbol
Smad1
resolver
genesymbol_syn
Madh1
resolver
genesymbol_syn
Madr1
resolver
uniprot
P70442
resolver
uniprot
Q6GT95
resolver
uniprot
Q9CYK6
resolver
uniprot_entry
SMAD1_MOUSE
resolver
uniprot_sec
P70442
resolver
uniprot_sec
Q6GT95
resolver
uniprot_sec
Q9CYK6
resolver
amino_acid_sequence
MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGGSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMAQDGSQPMDTNMMAPPLPAEISRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
uniprot
proteins
function
FUNCTION: Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:11566864, PubMed:15329343, PubMed:21420501, PubMed:35594155). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (PubMed:34995814). {ECO:0000250|UniProtKB:Q15797, ECO:0000269|PubMed:11566864, ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:21420501, ECO:0000269|PubMed:34995814, ECO:0000269|PubMed:35594155}.
uniprot
proteins
mass_dalton
52157
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of the C-terminal SVS motif by BMP type 1 receptor kinase activates SMAD1 by promoting dissociation from the receptor and trimerization with SMAD4. Phosphorylation by ERK2 MAP kinase in response to EGF or HGF prevents SMAD1 nuclear accumulation and transcriptional activity in response to BMP (By similarity). Dephosphorylation, probably by PPM1A, induces its export from the nucleus to the cytoplasm (PubMed:25755279). Dephosphorylation is inhibited by association with EGR1 (PubMed:35594155). Phosphorylation by CDK8/9 creates binding sites for YAP1, and subsequent phosphorylation by GSK3 switches off YAP1 binding and adds binding sites for SMURF1 (By similarity). {ECO:0000250|UniProtKB:Q15797, ECO:0000269|PubMed:25755279, ECO:0000269|PubMed:35594155}.; PTM: Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading to its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes. Dephosphorylation, probably by PPM1A, induces its export from the nucleus to the cytoplasm (By similarity). Phospho-SMAD1 is ubiquitinated by CHIP leading to disruption of the SMAD1-SMAD4 complex (By similarity). {ECO:0000250|UniProtKB:Q15797}.
uniprot
proteins
protein_family
Dwarfin/SMAD family
uniprot
proteins
pubmed
11094085
uniprot
proteins
pubmed
11111041
uniprot
proteins
pubmed
11566864
uniprot
proteins
pubmed
12370310
uniprot
proteins
pubmed
15329343
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16115198
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16801560
uniprot
proteins
pubmed
18160706
uniprot
proteins
pubmed
20147459
uniprot
proteins
pubmed
21239498
uniprot
proteins
pubmed
21420501
uniprot
proteins
pubmed
25755279
uniprot
proteins
pubmed
34995814
uniprot
proteins
pubmed
35594155
uniprot
proteins
pubmed
8799132
uniprot
proteins
pubmed
9076678
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25755279}. Nucleus {ECO:0000269|PubMed:25755279, ECO:0000269|PubMed:34995814}. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane (By similarity). Exported from the nucleus to the cytoplasm when dephosphorylated PubMed:25755279. {ECO:0000250|UniProtKB:Q15797, ECO:0000269|PubMed:25755279}.
uniprot
proteins