SLC25A27
entrez
9481
canonical
uniprot
O95847
canonical
ensembl
ENSG00000153291
resolver
ensp
ENSP00000360398
resolver
ensp
ENSP00000412024
resolver
ensp
ENSP00000798083
resolver
genesymbol
SLC25A27
resolver
genesymbol_syn
UCP4
resolver
hgnc
HGNC:21065
resolver
uniprot
B4DHR4
resolver
uniprot
F5GWR4
resolver
uniprot
Q5VTS9
resolver
uniprot
Q8N518
resolver
uniprot_entry
B4DHR4_HUMAN
resolver
uniprot_entry
UCP4_HUMAN
resolver
uniprot_sec
F5GWR4
resolver
uniprot_sec
Q5VTS9
resolver
uniprot_sec
Q8N518
resolver
activity_regulation
ACTIVITY REGULATION: Proton conductance is up-regulated by unsaturated long-chain fatty acids and inhibited by purine nucleotides ATP and ADP. The transport of chloride ions is partially inhibited by long-chain fatty acids. {ECO:0000269|PubMed:22524567, ECO:0000269|PubMed:26182433}.
uniprot
proteins
amino_acid_sequence
MSVPEEEERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIREMSGVSPF
uniprot
proteins
function
FUNCTION: Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, shifting the energy metabolism toward aerobic glycolysis and lactate transfer to neurons for ATP synthesis. Can transport chloride ions with lower efficiency. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q9D6D0, ECO:0000269|PubMed:10025957, ECO:0000269|PubMed:22524567, ECO:0000269|PubMed:26182433}.
uniprot
proteins
mass_dalton
36064
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
10025957
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22524567
uniprot
proteins
pubmed
26182433
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:10025957}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to neuronal cell body and processes. Within mitochondrial inner membrane, it is mainly observed in the inner boundary membrane locally separated from F(1)F(0) ATP synthase, which is preferentially localized in cristae. {ECO:0000250|UniProtKB:Q9D6D0}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..40; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 88..109; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 127..144; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 195..212; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 229..248; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 288..311; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins