AGTR2
entrez
186
canonical
uniprot
P50052
canonical
ensembl
ENSG00000180772
resolver
ensp
ENSP00000360973
resolver
ensp
ENSP00000505750
resolver
ensp
ENSP00000641283
resolver
enst
ENST00000371906
resolver
enst
ENST00000681852
resolver
enst
ENST00000971224
resolver
genesymbol
AGTR2
resolver
hgnc
HGNC:338
resolver
uniprot
B2R9V1
resolver
uniprot
Q13016
resolver
uniprot
Q6FGY7
resolver
uniprot_entry
AGTR2_HUMAN
resolver
uniprot_sec
B2R9V1
resolver
uniprot_sec
Q13016
resolver
uniprot_sec
Q6FGY7
resolver
amino_acid_sequence
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
uniprot
proteins
function
FUNCTION: Receptor for angiotensin II, a vasoconstricting peptide (PubMed:28379944, PubMed:29967536, PubMed:31899086, PubMed:8185599). Primarily signals via a non-canonical G protein- and beta-arrestin independent pathways (PubMed:28379944). Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (PubMed:15123706). {ECO:0000269|PubMed:15123706, ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:8185599}.
uniprot
proteins
mass_dalton
41184
uniprot
proteins
mutagenesis
MUTAGEN 104; /note="Y->A: Abolished angiotensin II-binding."; /evidence="ECO:0000269|PubMed:31899086"; MUTAGEN 108; /note="Y->A: Abolished angiotensin II-binding."; /evidence="ECO:0000269|PubMed:29967536"; MUTAGEN 128; /note="M->A: Abolished angiotensin II-binding."; /evidence="ECO:0000269|PubMed:31899086"; MUTAGEN 128; /note="M->L: Does not affect angiotensin II-binding."; /evidence="ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086"; MUTAGEN 182; /note="R->A: Abolished angiotensin II-binding."; /evidence="ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086"; MUTAGEN 215; /note="K->A,Q: Abolished angiotensin II-binding."; /evidence="ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086"; MUTAGEN 269; /note="W->A: Abolished angiotensin II-binding."; /evidence="ECO:0000269|PubMed:31899086"; MUTAGEN 272; /note="F->A: Abolished angiotensin II-binding."; /evidence="ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086"; MUTAGEN 272; /note="F->H: Does not affect angiotensin II-binding."; /evidence="ECO:0000269|PubMed:31899086"; MUTAGEN 297; /note="D->A: Abolished angiotensin II-binding."; /evidence="ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086"; MUTAGEN 308; /note="F->Y: Abolished angiotensin II-binding."; /evidence="ECO:0000269|PubMed:31899086
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12089445
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15123706
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
23871722
uniprot
proteins
pubmed
28379944
uniprot
proteins
pubmed
29967536
uniprot
proteins
pubmed
31899086
uniprot
proteins
pubmed
32669569
uniprot
proteins
pubmed
7719706
uniprot
proteins
pubmed
7733925
uniprot
proteins
pubmed
7790004
uniprot
proteins
pubmed
7945336
uniprot
proteins
pubmed
7999093
uniprot
proteins
pubmed
8185599
uniprot
proteins
sequence_length
363
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P35374}; Multi-pass membrane protein {ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..70; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569, ECO:0007744|PDB:5UNF, ECO:0007744|PDB:5UNG, ECO:0007744|PDB:5UNH, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD, ECO:0007744|PDB:7C6A"; TRANSMEM 81..104; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569, ECO:0007744|PDB:5UNF, ECO:0007744|PDB:5UNG, ECO:0007744|PDB:5UNH, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD, ECO:0007744|PDB:7C6A"; TRANSMEM 115..140; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569, ECO:0007744|PDB:5UNF, ECO:0007744|PDB:5UNG, ECO:0007744|PDB:5UNH, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD, ECO:0007744|PDB:7C6A"; TRANSMEM 160..181; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569, ECO:0007744|PDB:5UNF, ECO:0007744|PDB:5UNG, ECO:0007744|PDB:5UNH, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD, ECO:0007744|PDB:7C6A"; TRANSMEM 207..232; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569, ECO:0007744|PDB:5UNF, ECO:0007744|PDB:5UNG, ECO:0007744|PDB:5UNH, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD, ECO:0007744|PDB:7C6A"; TRANSMEM 258..281; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569, ECO:0007744|PDB:5UNF, ECO:0007744|PDB:5UNG, ECO:0007744|PDB:5UNH, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD, ECO:0007744|PDB:7C6A"; TRANSMEM 295..320; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569, ECO:0007744|PDB:5UNF, ECO:0007744|PDB:5UNG, ECO:0007744|PDB:5UNH, ECO:0007744|PDB:5XJM, ECO:0007744|PDB:6JOD, ECO:0007744|PDB:7C6A
uniprot
proteins