Pde4d
entrez
24627
canonical
uniprot
P14270
canonical
ensembl
ENSRNOG00000042536
resolver
ensp
ENSRNOP00000015138
resolver
ensp
ENSRNOP00000062384
resolver
ensp
ENSRNOP00000063446
resolver
ensp
ENSRNOP00000076534
resolver
ensp
ENSRNOP00000083636
resolver
ensp
ENSRNOP00000086862
resolver
ensp
ENSRNOP00000090781
resolver
ensp
ENSRNOP00000093090
resolver
ensp
ENSRNOP00000094176
resolver
enst
ENSRNOT00000015138
resolver
enst
ENSRNOT00000101684
resolver
enst
ENSRNOT00000112415
resolver
genesymbol
Pde4d
resolver
uniprot
A0A140TAB1
resolver
uniprot
A0A8I6ABM9
resolver
uniprot
A0A8I6GB00
resolver
uniprot
A1E347
resolver
uniprot
A1EC59
resolver
uniprot
F1M1H7
resolver
uniprot
O35470
resolver
uniprot
Q6TRI0
resolver
uniprot
Q8CG04
resolver
uniprot
Q8CG06
resolver
uniprot_entry
A0A140TAB1_RAT
resolver
uniprot_entry
A0A8I6ABM9_RAT
resolver
uniprot_entry
A0A8I6GB00_RAT
resolver
uniprot_entry
PDE4D_RAT
resolver
uniprot_sec
A1E347
resolver
uniprot_sec
A1EC59
resolver
uniprot_sec
F1M1H7
resolver
uniprot_sec
O35470
resolver
uniprot_sec
Q6TRI0
resolver
uniprot_sec
Q8CG04
resolver
uniprot_sec
Q8CG06
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphatidic acid (By similarity). Inhibited by rolipram. {ECO:0000250, ECO:0000269|PubMed:17261351}.
uniprot
proteins
amino_acid_sequence
MEAEGSSVPARAGSHEGSDSSGGAALKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQLQPPPPPPLPPPPPPPGATRGRYASSGASRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSCIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMAIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDQEDGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVAEEESQPQTGVADDCCPDT
uniprot
proteins
ec_number
3.1.4.53
uniprot
proteins
function
FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
uniprot
proteins
mass_dalton
90552
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
uniprot
proteins
post_translational_modification
PTM: Isoform 1 and isoform 9 are rapidly activated by PKA through phosphorylation. Long isoforms that share a conserved PKA phosphorylation site in the N-terminus are also activated. {ECO:0000269|PubMed:10187850}.; PTM: Sumoylation of long isoforms by PIAS4 augments their activation by PKA phosphorylation and represses their inhibition by ERK phosphorylation. {ECO:0000250}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE4 subfamily
uniprot
proteins
pubmed
10187850
uniprot
proteins
pubmed
11134006
uniprot
proteins
pubmed
11285255
uniprot
proteins
pubmed
12834813
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15717866
uniprot
proteins
pubmed
17244609
uniprot
proteins
pubmed
17261351
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2546153
uniprot
proteins
pubmed
2554303
uniprot
proteins
pubmed
7958996
uniprot
proteins
pubmed
8034568
uniprot
proteins
pubmed
8276818
uniprot
proteins
sequence_length
803
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane. Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome. Colocalized with SHANK2 to the apical membrane of colonic crypt cells.
uniprot
proteins