P11985
uniprot
P11985
canonical
amino_acid_sequence
MERRGRMAKTPTGQTHQSPVSKRERKPSMFEKESYAQILRERLRESFHDVQYVEPPFDDSIADVGKEWKSALAKLKFANSYRMEPLKKFQAHLVETKIQQILKDSLKDVKYDDKAPHLSLELADGILAAVKEFAYHRYKFIIQVLFIQKTGQAINIASRWIWDVAWDNWVEAKHETESYVVLALVFALYCE
uniprot
proteins
disease_involvement
DISEASE: Note=Could be involved in transmission ratio distortion (trd) in mouse t-haplotype which causes male sterility.
uniprot
proteins
function
FUNCTION: Component of dynein, a family of motor proteins essential for movement along microtubules (PubMed:11278908). Required for structural and functional integrity of cilia (By similarity). Candidate for involvement in male sterility (By similarity). {ECO:0000250|UniProtKB:C0HME8, ECO:0000269|PubMed:11278908}.
uniprot
proteins
mass_dalton
22379
uniprot
proteins
protein_family
Dynein light chain Tctex-type family
uniprot
proteins
pubmed
11278908
uniprot
proteins
pubmed
12849985
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1718647
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
3653077
uniprot
proteins
pubmed
38236177
uniprot
proteins
pubmed
7601308
uniprot
proteins
sequence_length
191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305|PubMed:7601308}. Cytoplasmic granule {ECO:0000269|PubMed:7601308}. Membrane {ECO:0000269|PubMed:7601308}; Peripheral membrane protein {ECO:0000269|PubMed:7601308}. Note=Found on the surface of sperm tail. Stored in cytoplasmic granules during spermatogenesis.
uniprot
proteins