TXK
entrez
7294
canonical
uniprot
P42681
canonical
ensembl
ENSG00000074966
resolver
ensp
ENSP00000264316
resolver
ensp
ENSP00000796427
resolver
enst
ENST00000264316
resolver
genesymbol
TXK
resolver
genesymbol_syn
PTK4
resolver
genesymbol_syn
RLK
resolver
hgnc
HGNC:12434
resolver
uniprot
Q14220
resolver
uniprot_entry
TXK_HUMAN
resolver
uniprot_sec
Q14220
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation by FYN. {ECO:0000269|PubMed:12081135}.
uniprot
proteins
amino_acid_sequence
MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Also contributes to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 (PubMed:11859127, PubMed:17177976). Within the complex, phosphorylates both PARP1 and EEF1A1 (PubMed:17177976). Also phosphorylates key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. {ECO:0000269|PubMed:10523612, ECO:0000269|PubMed:11564877, ECO:0000269|PubMed:11859127, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:9813138}.
uniprot
proteins
mass_dalton
61258
uniprot
proteins
mutagenesis
MUTAGEN 91; /note="Y->A: Reduces expression levels if IFN-gamma."; /evidence="ECO:0000269|PubMed:12081135"; MUTAGEN 299; /note="K->A: Impairs kinase activity."; /evidence="ECO:0000269|PubMed:9813138
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Tyr-420 by FYN. Autophosphorylation at Tyr-91 is critical for the activation of TXK, leading to the up-regulation of IFN-gamma gene transcription. {ECO:0000269|PubMed:12081135}.; PTM: The cysteine string at the N-terminus is palmitoylated and required for the proper subcellular location. {ECO:0000250}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TEC subfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10523612
uniprot
proteins
pubmed
11564877
uniprot
proteins
pubmed
11859127
uniprot
proteins
pubmed
12081135
uniprot
proteins
pubmed
17177976
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
19290923
uniprot
proteins
pubmed
7951233
uniprot
proteins
pubmed
8632917
uniprot
proteins
pubmed
9813138
uniprot
proteins
sequence_length
527
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17177976}. Nucleus {ECO:0000269|PubMed:17177976}. Cell membrane {ECO:0000269|PubMed:17177976}; Peripheral membrane protein {ECO:0000269|PubMed:17177976}. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells.
uniprot
proteins