Supt6
entrez
20926
canonical
uniprot
Q62383
canonical
ensembl
ENSMUSG00000002052
resolver
ensp
ENSMUSP00000002121
resolver
enst
ENSMUST00000002121
resolver
genesymbol
Supt6
resolver
genesymbol
Supt6h
resolver
genesymbol_syn
Kiaa0162
resolver
genesymbol_syn
Supt6
resolver
genesymbol_syn
Supt6h
resolver
uniprot
Q3TY72
resolver
uniprot
Q3UWU8
resolver
uniprot
Q5SYM0
resolver
uniprot
Q6GQS3
resolver
uniprot
Q6ZQI0
resolver
uniprot
Q8BQY6
resolver
uniprot_entry
Q3TY72_MOUSE
resolver
uniprot_entry
Q3UWU8_MOUSE
resolver
uniprot_entry
SPT6H_MOUSE
resolver
uniprot_sec
Q5SYM0
resolver
uniprot_sec
Q6GQS3
resolver
uniprot_sec
Q6ZQI0
resolver
uniprot_sec
Q8BQY6
resolver
amino_acid_sequence
MSDFVESEAEESEEEYNHEGEVVPRVTKKFVEEEDDDEEEEEENLDDQDERGNLKDFINDDDDEEEGEEDEGSDSGDSEDDVGHKKRKRPSFDDRLEDDDFDLIEENLGVKVKRGQKYRRVKKMSDDDEDDEEEYGKEEHEKEAIAGEIFQDEEGEEGQEAVEAPMAPPDEEEEDDEESDIDDFIVDDDGQPLKKPKWRKKLPGYTDAALQEAQEIFGVDFDYDEFEKYNEYDEELEEDYEYEDDETEGEIRVRPKKTTKKRVSRRSIFEMYEPSELESSHLTDQDNEIRATDLPERFQLRSIPVKAAEDDELEEEADWIYRNAFATPTISLQDSCDYLDRGQPTSSFSRKGPSTVQKIKEALGFMRNQHFEVPFIAFYRKEYVEPELHINDLWRVWQWDEKWTQLRIRKENLTRLFEKMQAYQYEQISADPDKPLADGIRALDTTDMERLKDVQSMDELKDVYNHFLLYYGRDIPKMQNAAKASRKKLKRIKEDGDEEGEGEEAEDEEQRGPELKQASRRDMYTICQSAGLDGLAKKFGLTPEQFGENLRDSYQRHETEQFPAEPLELAKDYVCSQFPTPEAVLEGARYMVALQIAREPLVRQVLRQTFQERAKLNITPTKKGRKDVDEAHYAYSFKYLKNKPVKELRDDQFLKIGLAEDEGLLTIDISIDMKGVEGYGNDQTYFEEIKQFYYRDEFSHQVQEWNRQRTMAIERALQQFLYVQMAKELKNKLLAEARESVVKACSRKLYNWLRVAPYRPDQQVEEDDDFMDENQGKGIRVLGIAFSSARDHPVFCALVNGEGEVTDFLRLPHFTKRRTAWREEEREKKAQDIETLKKFLVNKKPHVVTIAGENRDAQMLTEDVKRIVHELDQGQQLSSIGVELVDNELAILYMNSKKSEAEFRDYPPVLRQAVSLARRIQDPLIEFAQVCSSDEDILCLKFHPLQEHVVKEELLNALYCEFINRVNEVGVDVNRAIAHPYSQALIQYVCGLGPRKGTHLLKILKQNNTRLESRTQLVTMCHMGPKVFMNCAGFLKIDTASLGDSTDSYIEVLDGSRVHPETYEWARKMAVDALEYDESAEDANPAGALEEILENPERLKDLDLDAFAEELERQGYGDKHITLYDIRAELSCRYKDLRTAYRSPNTEEIFNMLTKETPETFYIGKLIICNVTGIAHRRPQGESYDQAIRNDETGLWQCPFCQQDNFPELSEVWNHFDSGSCPGQAIGVKTRLDNGVTGFIPTKFLSDKVVKRPEERVKVGMTVHCRIMKIDIEKFSADLTCRTSDLMDRNNEWKLPKDTYYDFDAEAADHKQEEDMKRKQQRTTYIKRVIAHPSFHNINFKQAEKMMETMDQGDVIIRPSSKGENHLTVTWKVSAGIYQHVDVREEGKENAFSLGATLWINSEEFEDLDEIVARYVQPMASFARDLLNHKYYQDCSGGDRKKLEELLIKTKKEKPTFIPYFICACKELPGKFLLGYQPRGKPRIEYVTVTPEGFRYRGQIFPTVNGLFRWFKDHYQDPVPGITPSSSNRTRTPASINATPANINLADLTRAVNALPQNMTSQMFSAIAAVTGQGQNPNATPAQWASSQYGYGGSGGGSSAYHVFPTPAQQPVATPLMTPSYSYTTPSQPITTPQYHQLQASTTPQSTQAQPQPSSSSRQRQQQPKSNSHAAIDWGKMAEQWLQEKEAERRKQKQRLTPRPSPSPMIESTPMSIAGDATPLLDEMDR
uniprot
proteins
function
FUNCTION: Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:21518874, ECO:0000269|PubMed:22843687, ECO:0000269|PubMed:23503590}.
uniprot
proteins
mass_dalton
199086
uniprot
proteins
mutagenesis
MUTAGEN 1358; /note="R->K: Loss of binding to POLR2A. Retains the ability to support transcription elongation but the resulting transcripts contain splicing defects and accumulate to high levels within the nucleus."; /evidence="ECO:0000269|PubMed:17234882
uniprot
proteins
post_translational_modification
PTM: Dephosphorylated at Ser-1530 by the PNUTS-PP1 complex during RNA polymerase II transcription pause-release. {ECO:0000250|UniProtKB:Q7KZ85}.
uniprot
proteins
protein_family
SPT6 family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17234882
uniprot
proteins
pubmed
19141475
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21518874
uniprot
proteins
pubmed
22843687
uniprot
proteins
pubmed
23503590
uniprot
proteins
pubmed
31128943
uniprot
proteins
pubmed
8786132
uniprot
proteins
sequence_length
1726
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins