Lamp2
entrez
16784
canonical
uniprot
P17047
canonical
ensembl
ENSMUSG00000016534
resolver
ensp
ENSMUSP00000016678
resolver
ensp
ENSMUSP00000052283
resolver
ensp
ENSMUSP00000074448
resolver
genesymbol
Lamp2
resolver
genesymbol_syn
Lamp-2
resolver
uniprot
A2A430
resolver
uniprot
Q3TXG5
resolver
uniprot
Q8BSG8
resolver
uniprot
Q8C5K0
resolver
uniprot_entry
LAMP2_MOUSE
resolver
uniprot_entry
Q8C5K0_MOUSE
resolver
uniprot_sec
A2A430
resolver
uniprot_sec
Q3TXG5
resolver
uniprot_sec
Q8BSG8
resolver
amino_acid_sequence
MCLSPVKGAKLILIFLFLGAVQSNALIVNLTDSKGTCLYAEWEMNFTITYETTNQTNKTITIAVPDKATHDGSSCGDDRNSAKIMIQFGFAVSWAVNFTKEASHYSIHDIVLSYNTSDSTVFPGAVAKGVHTVKNPENFKVPLDVIFKCNSVLTYNLTPVVQKYWGIHLQAFVQNGTVSKNEQVCEEDQTPTTVAPIIHTTAPSTTTTLTPTSTPTPTPTPTPTVGNYSIRNGNTTCLLATMGLQLNITEEKVPFIFNINPATTNFTGSCQPQSAQLRLNNSQIKYLDFIFAVKNEKRFYLKEVNVYMYLANGSAFNISNKNLSFWDAPLGSSYMCNKEQVLSVSRAFQINTFNLKVQPFNVTKGQYSTAQDCSADEDNFLVPIAVGAALGGVLILVLLAYFIGLKRHHTGYEQF
uniprot
proteins
function
FUNCTION: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy (PubMed:10972293, PubMed:30718432). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (By similarity). Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:30718432). Functions by binding target proteins, such as GAPDH, GPX4, NLRP3 and MLLT11, and targeting them for lysosomal degradation (PubMed:30718432). In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2 (By similarity). Plays a role in lysosomal protein degradation in response to starvation (PubMed:27628032). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:10972293, PubMed:12221139). Required for efficient MHC class II-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHC II subunits (By similarity). Is not required for efficient MHC class II-mediated presentation of endogenous antigens (By similarity). {ECO:0000250|UniProtKB:P13473, ECO:0000269|PubMed:10972293, ECO:0000269|PubMed:12221139, ECO:0000269|PubMed:27628032, ECO:0000269|PubMed:30718432}.
uniprot
proteins
mass_dalton
45681
uniprot
proteins
post_translational_modification
PTM: Extensively N-glycosylated. Contains a minor proportion of O-linked glycans. {ECO:0000269|PubMed:2142158}.
uniprot
proteins
protein_family
LAMP family
uniprot
proteins
pubmed
10972293
uniprot
proteins
pubmed
11082038
uniprot
proteins
pubmed
12221139
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2142158
uniprot
proteins
pubmed
22641697
uniprot
proteins
pubmed
2318880
uniprot
proteins
pubmed
27628032
uniprot
proteins
pubmed
27663661
uniprot
proteins
pubmed
30718432
uniprot
proteins
pubmed
38744829
uniprot
proteins
pubmed
7546292
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:11082038, ECO:0000269|PubMed:2142158}; Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740}. Endosome membrane {ECO:0000250|UniProtKB:P13473}; Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:12221139}. Cell membrane {ECO:0000250|UniProtKB:P13473}; Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. {ECO:0000250|UniProtKB:P13473}.
uniprot
proteins
transmembrane_region
TRANSMEM 380..404; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00740
uniprot
proteins