Sars1
entrez
20226
canonical
uniprot
P26638
canonical
ensembl
ENSMUSG00000068739
resolver
ensp
ENSMUSP00000088041
resolver
ensp
ENSMUSP00000099685
resolver
enst
ENSMUST00000090553
resolver
enst
ENSMUST00000102625
resolver
genesymbol
Sars1
resolver
genesymbol_syn
Sars
resolver
genesymbol_syn
Sers
resolver
uniprot
A2AFR8
resolver
uniprot
F6T3N7
resolver
uniprot
Q8C483
resolver
uniprot_entry
F6T3N7_MOUSE
resolver
uniprot_entry
Q8C483_MOUSE
resolver
uniprot_entry
SYSC_MOUSE
resolver
uniprot_sec
A2AFR8
resolver
amino_acid_sequence
MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEAVGDDESVPENVLNFDDLTADALAALKVSQIKKVRLLIDEAIQKCDGERVKLEAERFENLREIGNLLHPSVPISNDEDADNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGPLVFLEQALIQYALRTLGSRGYTPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFDEMIATAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQAEKGIAVPEKLREFMPPGLQELIPFVKPAPIDQEPSKKQKKQHEGSKKKAKEVPLENQLQSMEVTEA
uniprot
proteins
ec_number
6.1.1.11
uniprot
proteins
function
FUNCTION: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA. {ECO:0000250|UniProtKB:P49591}.
uniprot
proteins
mass_dalton
58389
uniprot
proteins
pathway_participation
PATHWAY: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.
uniprot
proteins
protein_family
Class-II aminoacyl-tRNA synthetase family
uniprot
proteins
protein_family
Type-1 seryl-tRNA synthetase subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1918033
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P49591}. Nucleus {ECO:0000250|UniProtKB:P49591}. Note=Predominantly cytoplasmic, but a minor proportion is also found in the nucleus. {ECO:0000250|UniProtKB:P49591}.
uniprot
proteins