FAAP20
entrez
199990
canonical
uniprot
Q6NZ36
canonical
ensembl
ENSG00000162585
resolver
ensp
ENSP00000367804
resolver
ensp
ENSP00000367808
resolver
ensp
ENSP00000383709
resolver
ensp
ENSP00000383710
resolver
ensp
ENSP00000409721
resolver
ensp
ENSP00000574977
resolver
ensp
ENSP00000644761
resolver
ensp
ENSP00000644768
resolver
ensp
ENSP00000644769
resolver
enst
ENST00000400919
resolver
enst
ENST00000420515
resolver
genesymbol
FAAP20
resolver
genesymbol_syn
C1orf86
resolver
hgnc
HGNC:26428
resolver
uniprot
A6PW39
resolver
uniprot
A6PW40
resolver
uniprot
A6PW41
resolver
uniprot
A8MQT6
resolver
uniprot
F2Z2L4
resolver
uniprot
F6S8H2
resolver
uniprot
H7C361
resolver
uniprot
Q6ZRT9
resolver
uniprot
Q6ZT64
resolver
uniprot
Q71M24
resolver
uniprot
Q7Z4P6
resolver
uniprot
Q96ND7
resolver
uniprot_entry
F6S8H2_HUMAN
resolver
uniprot_entry
FAP20_HUMAN
resolver
uniprot_entry
H7C361_HUMAN
resolver
uniprot_entry
Q6ZRT9_HUMAN
resolver
uniprot_entry
Q7Z4P6_HUMAN
resolver
uniprot_sec
A6PW39
resolver
uniprot_sec
A6PW40
resolver
uniprot_sec
A6PW41
resolver
uniprot_sec
A8MQT6
resolver
uniprot_sec
F2Z2L4
resolver
uniprot_sec
Q6ZT64
resolver
uniprot_sec
Q71M24
resolver
uniprot_sec
Q96ND7
resolver
amino_acid_sequence
MEAARRPRLGLSRRRPRPAGGPSGGRPWFLLGGDERERLWAELLRTVSPELILDHEVPSLPAFPGQEPRCGPEPTEVFTVGPKTFSWTPFPPDLWGPGRSYRLLHGAGGHLESPARSLPQRPAPDPCRAPRVEQQPSVEGAAALRSCPMCQKEFAPRLTQLDVDSHLAQCLAESTEDVTW
uniprot
proteins
function
FUNCTION: Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1. {ECO:0000269|PubMed:22266823, ECO:0000269|PubMed:22343915, ECO:0000269|PubMed:22396592, ECO:0000269|PubMed:22705371}.
uniprot
proteins
mass_dalton
19869
uniprot
proteins
mutagenesis
MUTAGEN 147; /note="C->A: Abolishes binding to ubiquitin. Abolishes binding to ubiquitin; when associated with A-150."; /evidence="ECO:0000269|PubMed:22266823, ECO:0000269|PubMed:22396592, ECO:0000269|PubMed:22705371"; MUTAGEN 150; /note="C->A: Abolishes binding to ubiquitin; when associated with A-147."; /evidence="ECO:0000269|PubMed:22266823, ECO:0000269|PubMed:22396592"; MUTAGEN 164; /note="D->A: Abolishes binding to ubiquitin."; /evidence="ECO:0000269|PubMed:22705371"; MUTAGEN 170; /note="C->A: Abolishes binding to ubiquitin."; /evidence="ECO:0000269|PubMed:22343915
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
22266823
uniprot
proteins
pubmed
22343915
uniprot
proteins
pubmed
22396592
uniprot
proteins
pubmed
22705371
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
180
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22343915, ECO:0000269|PubMed:22705371}. Chromosome {ECO:0000305|PubMed:22343915, ECO:0000305|PubMed:22705371}. Note=Following DNA damage, recruited to DNA interstrand cross-links (ICLs) sites by binding to ubiquitin generated by RNF8. {ECO:0000269|PubMed:22705371}.
uniprot
proteins