Meox2
entrez
17286
canonical
uniprot
P32443
canonical
ensembl
ENSMUSG00000036144
resolver
ensp
ENSMUSP00000043587
resolver
enst
ENSMUST00000041183
resolver
genesymbol
Meox2
resolver
genesymbol_syn
Gax
resolver
genesymbol_syn
Mox-2
resolver
genesymbol_syn
Mox2
resolver
uniprot
Q544T6
resolver
uniprot_entry
MEOX2_MOUSE
resolver
uniprot_sec
Q544T6
resolver
amino_acid_sequence
MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHQQQQHQALQSNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPADVEKRSGSKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTGDSLANEDSRDSDHSSEHAHL
uniprot
proteins
function
FUNCTION: Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (PubMed:10403250, PubMed:12925591, PubMed:1363541). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (PubMed:10403250). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis (PubMed:16116430). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (By similarity). While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (By similarity). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (PubMed:25561514). {ECO:0000250|UniProtKB:P39020, ECO:0000250|UniProtKB:P50222, ECO:0000269|PubMed:10403250, ECO:0000269|PubMed:12925591, ECO:0000269|PubMed:1363541, ECO:0000269|PubMed:16116430, ECO:0000269|PubMed:25561514}.
uniprot
proteins
mass_dalton
33506
uniprot
proteins
pubmed
10403250
uniprot
proteins
pubmed
12925591
uniprot
proteins
pubmed
1363541
uniprot
proteins
pubmed
16116430
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16284941
uniprot
proteins
pubmed
25561514
uniprot
proteins
pubmed
7623821
uniprot
proteins
pubmed
7909944
uniprot
proteins
sequence_length
303
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P50222}. Nucleus speckle {ECO:0000250|UniProtKB:P50222}.
uniprot
proteins