FOXP1
entrez
27086
canonical
uniprot
Q9H334
canonical
ensembl
ENSG00000114861
resolver
ensembl
ENSG00000285708
resolver
ensp
ENSP00000318721
resolver
ensp
ENSP00000318902
resolver
ensp
ENSP00000417857
resolver
ensp
ENSP00000418102
resolver
ensp
ENSP00000418524
resolver
ensp
ENSP00000420736
resolver
ensp
ENSP00000482847
resolver
ensp
ENSP00000496841
resolver
ensp
ENSP00000496968
resolver
ensp
ENSP00000496990
resolver
ensp
ENSP00000497077
resolver
ensp
ENSP00000497096
resolver
ensp
ENSP00000497369
resolver
ensp
ENSP00000497430
resolver
ensp
ENSP00000497435
resolver
ensp
ENSP00000497567
resolver
ensp
ENSP00000497693
resolver
ensp
ENSP00000498110
resolver
ensp
ENSP00000638368
resolver
enst
ENST00000491238
resolver
enst
ENST00000614176
resolver
enst
ENST00000648710
resolver
enst
ENST00000648748
resolver
enst
ENST00000648794
resolver
enst
ENST00000649592
resolver
enst
ENST00000649610
resolver
enst
ENST00000649695
resolver
enst
ENST00000650188
resolver
enst
ENST00000650387
resolver
genesymbol
FOXP1
resolver
hgnc
HGNC:3823
resolver
uniprot
A0A024R346
resolver
uniprot
A0A0B4J2F3
resolver
uniprot
A0A3B3IRW5
resolver
uniprot
A0A3B3IS20
resolver
uniprot
A0A3B3IST0
resolver
uniprot
A0A3B3IT66
resolver
uniprot
A0A5H1ZRR8
resolver
uniprot
A3QVP8
resolver
uniprot
B3KV70
resolver
uniprot
G5E9V8
resolver
uniprot
Q548T7
resolver
uniprot
Q8N2P0
resolver
uniprot
Q8NAN6
resolver
uniprot
Q8TEA2
resolver
uniprot
Q9BSG9
resolver
uniprot
Q9H332
resolver
uniprot
Q9H333
resolver
uniprot
Q9P0R1
resolver
uniprot_entry
A0A0B4J2F3_HUMAN
resolver
uniprot_entry
A0A3B3IRW5_HUMAN
resolver
uniprot_entry
A0A3B3IST0_HUMAN
resolver
uniprot_entry
A0A3B3IT66_HUMAN
resolver
uniprot_entry
FOXP1_HUMAN
resolver
uniprot_entry
Q548T7_HUMAN
resolver
uniprot_entry
Q8N2P0_HUMAN
resolver
uniprot_entry
Q8TEA2_HUMAN
resolver
uniprot_sec
A0A024R346
resolver
uniprot_sec
A0A3B3IS20
resolver
uniprot_sec
A0A5H1ZRR8
resolver
uniprot_sec
A3QVP8
resolver
uniprot_sec
B3KV70
resolver
uniprot_sec
G5E9V8
resolver
uniprot_sec
Q8NAN6
resolver
uniprot_sec
Q9BSG9
resolver
uniprot_sec
Q9H332
resolver
uniprot_sec
Q9H333
resolver
uniprot_sec
Q9P0R1
resolver
amino_acid_sequence
MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAVDIGAADLAHAQQQQQQALQVARQLLLQQQQQQQVSGLKSPKRNDKQPALQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQQLQEFYKKQQEQLQLQLLQQQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLAQGMIPTELQQLWKEVTSAHTAEETTGNNHSSLDLTTTCVSSSAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCEDFQSFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPTLGNLASAIREELNGAMEHTNSNESDSSPGRSPMQAVHPVHVKEEPLDPEEAEGPLSLVTTANHSPDFDHDRDYEDEPVNEDME
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.; DISEASE: Intellectual developmental disorder with language impairment and with or without autistic features (IDDLA) [MIM:613670]: A developmental disorder characterized by mild to moderate intellectual disability, language impairment, and autistic features in some patients. Patients show global delay, delayed walking, severely delayed speech development, and behavioral abnormalities, including irritability, hyperactivity, aggression, and stereotypical rigid behaviors. {ECO:0000269|PubMed:20848658, ECO:0000269|PubMed:20950788, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:29463886}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}.
uniprot
proteins
mass_dalton
75317
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11751404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15286807
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17344859
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18347093
uniprot
proteins
pubmed
18640093
uniprot
proteins
pubmed
18799727
uniprot
proteins
pubmed
19352412
uniprot
proteins
pubmed
20848658
uniprot
proteins
pubmed
20950788
uniprot
proteins
pubmed
21416545
uniprot
proteins
pubmed
21924763
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24023716
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25027557
uniprot
proteins
pubmed
25267198
uniprot
proteins
pubmed
26647308
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28218735
uniprot
proteins
pubmed
29463886
uniprot
proteins
pubmed
30250039
uniprot
proteins
pubmed
32891193
uniprot
proteins
sequence_length
677
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25027557, ECO:0000269|PubMed:26647308}. Note=Not found in the nucleolus. {ECO:0000269|PubMed:26647308}.
uniprot
proteins