Gins3
entrez
78833
canonical
uniprot
Q9CY94
canonical
ensembl
ENSMUSG00000031669
resolver
ensp
ENSMUSP00000034094
resolver
enst
ENSMUST00000034094
resolver
genesymbol
Gins3
resolver
genesymbol_syn
Psf3
resolver
uniprot_entry
PSF3_MOUSE
resolver
amino_acid_sequence
MSEAYFPVESGALGPEENFLSLDDILMSQEKLPVRVETPMPRLGAFFLERGAGSEPDHPLPQGTKLELPLWLAKGLFDHKRRILSVELPKMYQEGWRTVFSADANVVDLHKMGPHFYGFGSQLLHFDSPENADISQSLLKTFIGRFRRIMDSSQNSYNEDTSALVARLDETERGLFQIGQRSLNDFQSWEKGQASQITASSLVQNYKKRKFTNMED
uniprot
proteins
function
FUNCTION: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. {ECO:0000250|UniProtKB:Q9BRX5}.
uniprot
proteins
mass_dalton
24577
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="D->N: At homozygosity it results in embryonic lethality."; /evidence="ECO:0000269|PubMed:35603789
uniprot
proteins
protein_family
GINS3/PSF3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
35603789
uniprot
proteins
sequence_length
216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BRX5}. Chromosome {ECO:0000250|UniProtKB:Q9BRX5}. Note=Associates with chromatin. {ECO:0000250|UniProtKB:Q9BRX5}.
uniprot
proteins