Ttll6
entrez
237930
canonical
uniprot
A4Q9E8
canonical
ensembl
ENSMUSG00000038756
resolver
ensp
ENSMUSP00000103307
resolver
ensp
ENSMUSP00000127778
resolver
genesymbol
Ttll6
resolver
uniprot
A2A6M6
resolver
uniprot
B2RQS4
resolver
uniprot
Q3UL10
resolver
uniprot
Q8BVQ1
resolver
uniprot_entry
TTLL6_MOUSE
resolver
uniprot_sec
A2A6M6
resolver
uniprot_sec
B2RQS4
resolver
uniprot_sec
Q3UL10
resolver
uniprot_sec
Q8BVQ1
resolver
amino_acid_sequence
MLQCLTSESEEGAEEREESSTEDLEELKEFVTLAFVRENTQKRLQNAQQHGKKKRKKKRLVINLSNCRYDSVRRAAQQYGLREAGDNDDWTLYWTDYSVSLERVMEMKSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADWGDLQTYSRTRKNKTYICKPDSGCQGRGIFITRSVKEIKPGEDMICQLYISKPFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNLDNLDEICMHLTNYSINKHSSNFVQDAFSGSKRKLSTFNSYMKTHGYDVEQIWRGIEDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPWLLEVNHSPSFSTDSKLDKEVKDSLLYDALVLINLGNCDKKKVLEEERQRGRFLQQCPNREIRLEEVKGFQAMRLQKTEEYEKKNCGGFRLIYPGLNLEKYDKFFQDNSSLFQNTVASRARELYARQLIQELRQKQEKKVFLKKARKEETQGESAGEQARDKVVRLQRQRQQPKCKTVATCPPKQSLHPVTLVSCTSGLLLNIRGLKKGEISESLEQKDTKEAMLIPCKPVSARNYSSVPDLRSANPSCFEPEFHVPNAKVKEVKSAFMVNIESTAQPITSVESSRDATAPISTSLESLASMSLSTSPECSSPESVHMVSYNHKQQKASFHKPMQEKKSKPLMFSKSRHLDLNCTSMKNDINRQYLMSEILQKVQMKKKRPLFPAPKSQYPTLSKERCPHSRSSSRKKEMNSPSVFVLQASHSRAESLNDLLVVATQARLDPRPSRSHSGTTTRDSSTQDPKHTATA
uniprot
proteins
ec_number
6.3.2.-
uniprot
proteins
function
FUNCTION: Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins (PubMed:17499049, PubMed:20530212, PubMed:21074048, PubMed:26829768, PubMed:32747782). Preferentially mediates ATP-dependent long polyglutamate chain elongation over the initiation step of the polyglutamylation reaction (PubMed:17499049, PubMed:20530212, PubMed:21074048, PubMed:26829768, PubMed:32747782). Preferentially modifies the alpha-tubulin tail over a beta-tail (PubMed:17499049, PubMed:20530212, PubMed:21074048, PubMed:32747782). Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions (PubMed:20530212). Mediates microtubule polyglutamylation in primary cilia axoneme which is important for ciliary structural formation and motility (PubMed:22246503). Mediates microtubule polyglutamylation in motile cilia, necessary for the regulation of ciliary coordinated beating (PubMed:23897886). Polyglutamylates non-tubulin protein nucleotidyltransferase CGAS, leading to CGAS DNA-binding inhibition, thereby preventing antiviral defense response (PubMed:26829768). {ECO:0000269|PubMed:17499049, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21074048, ECO:0000269|PubMed:22246503, ECO:0000269|PubMed:23897886, ECO:0000269|PubMed:26829768, ECO:0000269|PubMed:32747782}.
uniprot
proteins
mass_dalton
94507
uniprot
proteins
mutagenesis
MUTAGEN 125; /note="K->A: Loss of alpha-tubulin alpha-elongation step of polyglutamylase activity."; /evidence="ECO:0000269|PubMed:32747782"; MUTAGEN 174; /note="K->A: Loss of alpha-tubulin alpha-elongation step of polyglutamylase activity."; /evidence="ECO:0000269|PubMed:32747782"; MUTAGEN 179; /note="C->A: Strong increase in alpha-tubulin initiation step of polyglutamylase activity; when associated with R-180 and I-362. Strong increase in alpha-tubulin initiation step of polyglutamylase activity; when associated with R-180, I-182, I-362 and H-367."; /evidence="ECO:0000269|PubMed:32747782"; MUTAGEN 179; /note="C->V: Decreased alpha-tubulin alpha-elongation step of polyglutamylase activity."; /evidence="ECO:0000269|PubMed:32747782"; MUTAGEN 180; /note="Q->A: Decreased alpha-tubulin alpha-elongation step of polyglutamylase activity."; /evidence="ECO:0000269|PubMed:32747782"; MUTAGEN 180; /note="Q->R: Increased alpha-tubulin initiation step of polyglutamylase activity. Increased alpha-tubulin initiation step of polyglutamylase activity; when associated with I-362. Strong increase in alpha-tubulin initiation step of polyglutamylase activity; when associated with A-179 and I-362. Strong increase in alpha-tubulin initiation step of polyglutamylase activity; when associated with A-179, I-182, I-362 and H-367."; /evidence="ECO:0000269|PubMed:32747782"; MUTAGEN 182; /note="R->I: Strong increase in alpha-tubulin initiation step of polyglutamylase activity; when associated with A-179, R-180, I-362 and H-367."; /evidence="ECO:0000269|PubMed:32747782"; MUTAGEN 219; /note="R->A: Loss of alpha-tubulin alpha-elongation polyglutamylase activity."; /evidence="ECO:0000269|PubMed:32747782"; MUTAGEN 241; /note="R->A: Loss of alpha-tubulin alpha-elongation step of polyglutamylase activity."; /evidence="ECO:0000269|PubMed:32747782"; MUTAGEN 264; /note="N->A: Loss of alpha-tubulin alpha-elongation step of polyglutamylase activity."; /evidence="ECO:0000269|PubMed:32747782"; MUTAGEN 283; /note="K->A: Loss of alpha-tubulin alpha-elongation step of polyglutamylase activity."; /evidence="ECO:0000269|PubMed:32747782"; MUTAGEN 346; /note="D->A: Loss of alpha-tubulin alpha-elongation step of polyglutamylase activity."; /evidence="ECO:0000269|PubMed:32747782"; MUTAGEN 359; /note="E->Q: Loss of alpha-tubulin alpha-elongation step of polyglutamylase activity."; /evidence="ECO:0000269|PubMed:32747782"; MUTAGEN 362; /note="H->A: Decreased alpha-tubulin alpha-elongation step of polyglutamylase activity."; /evidence="ECO:0000269|PubMed:32747782"; MUTAGEN 362; /note="H->I: Small increase in alpha-tubulin initiation step of polyglutamylase activity. Increased alpha-tubulin initiation step of polyglutamylase activity; when associated with R-180. Strong increase in alpha-tubulin initiation step of polyglutamylase activity; when associated with A-179 and R-180. Strong increase in alpha-tubulin initiation step of polyglutamylase activity; when associated with A-179, R-180, I-362 and H-367."; /evidence="ECO:0000269|PubMed:32747782"; MUTAGEN 367; /note="S->H: Strong increase in alpha-tubulin initiation step of polyglutamylase activity; when associated with A-179, R-180, I-182 and I-262."; /evidence="ECO:0000269|PubMed:32747782"; MUTAGEN 377; /note="K->A: Loss of alpha-tubulin alpha-elongation step of polyglutamylase activity."; /evidence="ECO:0000269|PubMed:32747782
uniprot
proteins
protein_family
Tubulin--tyrosine ligase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17499049
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20530212
uniprot
proteins
pubmed
21074048
uniprot
proteins
pubmed
22246503
uniprot
proteins
pubmed
23897886
uniprot
proteins
pubmed
26829768
uniprot
proteins
pubmed
32747782
uniprot
proteins
sequence_length
822
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26829768}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:20530212}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:17499049}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17499049}. Note=CEP41 is required for its transport between the basal body and the cilium axoneme. {ECO:0000250|UniProtKB:Q8N841}.
uniprot
proteins