Tns4
entrez
303517
canonical
uniprot
Q4V8I3
canonical
ensembl
ENSRNOG00000027350
resolver
ensembl
ENSRNOG00055033303
resolver
ensembl
ENSRNOG00060030933
resolver
ensp
ENSRNOP00000073971
resolver
ensp
ENSRNOP00055047458
resolver
ensp
ENSRNOP00060044589
resolver
enst
ENSRNOT00000089131
resolver
enst
ENSRNOT00055057566
resolver
enst
ENSRNOT00060053715
resolver
genesymbol
Tns4
resolver
uniprot
G3V8W6
resolver
uniprot_entry
TENS4_RAT
resolver
uniprot_sec
G3V8W6
resolver
amino_acid_sequence
MSSSLLTGGHVVSLTPHEESRMALHPTPSHDLPALCPYYTTESWGTQPLMDPTLCKGSSNRLQQAQQAEARAQCLLQCPGEQASGASQDLDSCIDFSLEALNKMILELDPTFQLLPSGIAGPQAEPTNSVASRTKKEEPDALDIKYIEVTSTRSRCLDSPQRCSSPCVTPPFGSPRSGGLFLSRDIPRETRSSSNESLIFSGNQGRGSSPHTPSSLSNSIPCRESRASGSPLATPPGWEKGLRAPQWGSRVSTLSASPVSDISYVFGSNQSLPHSSLSSYPPSSRSLGSPASSSSSLHSLDRGSQCVRSSDAQVPSNPIVGMGQPQAVPSTPVAKEQASSCPPSVTNSMADIPIVLINGNPEPQSPPAQQTPRYQDSVQSRATSPSHLCQATKSHSKTLPDVPLTSPSHLCQATKSHSKTLPDVPLTASPESPAKDMQPTMKFVMDTSKYWFKPSITREQAINLLRTEKPGTFVIRDSSSYRGSFGLALKVQETPASAPNRPGEDSTDFIRHFLVESSAKGVHLKGADEEPYFGSLSAFVCQHSIMALALPCKLTIPQKELGGAEPASDSPTHGQTSCLKISAGCHTLYLTSVSVETLSGALAVQKAISVMLERDVLPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLIALRFCGMDPEQRKWQKYCKPSRIFGFVAKSQTEPQENACHLFAEYDAAQPASQVISLVTALLKDTERV
uniprot
proteins
function
FUNCTION: Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration. Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF. Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration. {ECO:0000250|UniProtKB:Q8IZW8}.
uniprot
proteins
mass_dalton
77279
uniprot
proteins
protein_family
PTEN phosphatase protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
718
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q8IZW8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8IZW8}.
uniprot
proteins