Lpar1
entrez
14745
canonical
uniprot
P61793
canonical
ensembl
ENSMUSG00000038668
resolver
ensp
ENSMUSP00000052581
resolver
ensp
ENSMUSP00000103196
resolver
ensp
ENSMUSP00000103201
resolver
ensp
ENSMUSP00000310637
resolver
ensp
ENSMUSP00000310640
resolver
ensp
ENSMUSP00000310642
resolver
ensp
ENSMUSP00000310646
resolver
ensp
ENSMUSP00000310648
resolver
ensp
ENSMUSP00000310649
resolver
ensp
ENSMUSP00000310652
resolver
ensp
ENSMUSP00000310655
resolver
ensp
ENSMUSP00000310660
resolver
ensp
ENSMUSP00000310662
resolver
ensp
ENSMUSP00000328896
resolver
ensp
ENSMUSP00000328897
resolver
genesymbol
Lpar1
resolver
genesymbol_syn
Edg2
resolver
genesymbol_syn
Gpcr26
resolver
genesymbol_syn
Lpa1
resolver
genesymbol_syn
Vzg1
resolver
uniprot
A2AMJ2
resolver
uniprot
O88584
resolver
uniprot
P56487
resolver
uniprot
P70420
resolver
uniprot
Q544V2
resolver
uniprot
Q61130
resolver
uniprot_entry
LPAR1_MOUSE
resolver
uniprot_entry
Q544V2_MOUSE
resolver
uniprot_sec
A2AMJ2
resolver
uniprot_sec
O88584
resolver
uniprot_sec
P56487
resolver
uniprot_sec
P70420
resolver
uniprot_sec
Q61130
resolver
amino_acid_sequence
MAAASTSSPVISQPQFTAMNEQQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVCVFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIDHCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRNENPNGPTEGSDRSASSLNHTILAGVHSNDHSVV
uniprot
proteins
function
FUNCTION: Receptor for lysophosphatidic acid (LPA) (PubMed:11087877, PubMed:18066075). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins (PubMed:11040035, PubMed:18066075, PubMed:18157949, PubMed:23478264, PubMed:8922387, PubMed:9600933). Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:11040035, PubMed:12215548). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:12215548). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:11040035, PubMed:12215548, PubMed:23478264). Signaling mediates activation of down-stream MAP kinases (PubMed:11040035). Contributes to the regulation of cell shape (PubMed:11040035, PubMed:11087877, PubMed:8922387, PubMed:9600933). Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:11040035, PubMed:12181339, PubMed:9600933). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:12215548, PubMed:9600933). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (PubMed:23478264). Through its function as LPA receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:11087877, PubMed:18066075, PubMed:23478264). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14 (PubMed:21821728). Promotes cell proliferation in response to LPA (PubMed:11087877, PubMed:12215548, PubMed:17692995, PubMed:18157949, PubMed:23478264, PubMed:9600933). Inhibits the intracellular ciliogenesis pathway in response to LPA and through AKT1 activation (By similarity). Required for normal skeleton development (PubMed:21569876). May play a role in osteoblast differentiation (PubMed:21569876). Required for normal brain development (PubMed:17656621, PubMed:18708146). Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus (PubMed:18708146). Plays a role in pain perception and in the initiation of neuropathic pain (PubMed:15195086, PubMed:19689455). {ECO:0000250|UniProtKB:Q92633, ECO:0000269|PubMed:11040035, ECO:0000269|PubMed:11087877, ECO:0000269|PubMed:12181339, ECO:0000269|PubMed:12215548, ECO:0000269|PubMed:15195086, ECO:0000269|PubMed:17656621, ECO:0000269|PubMed:17692995, ECO:0000269|PubMed:18066075, ECO:0000269|PubMed:18157949, ECO:0000269|PubMed:18708146, ECO:0000269|PubMed:19689455, ECO:0000269|PubMed:21569876, ECO:0000269|PubMed:23478264, ECO:0000269|PubMed:8922387, ECO:0000269|PubMed:9600933}.
uniprot
proteins
mass_dalton
41119
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q92633}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11040035
uniprot
proteins
pubmed
11087877
uniprot
proteins
pubmed
11093753
uniprot
proteins
pubmed
12181339
uniprot
proteins
pubmed
12215548
uniprot
proteins
pubmed
15195086
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17656621
uniprot
proteins
pubmed
17692995
uniprot
proteins
pubmed
18066075
uniprot
proteins
pubmed
18157949
uniprot
proteins
pubmed
18708146
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19689455
uniprot
proteins
pubmed
20358347
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21569876
uniprot
proteins
pubmed
21821728
uniprot
proteins
pubmed
23478264
uniprot
proteins
pubmed
25226845
uniprot
proteins
pubmed
25732591
uniprot
proteins
pubmed
8922387
uniprot
proteins
pubmed
9013780
uniprot
proteins
pubmed
9600933
uniprot
proteins
pubmed
9721207
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell surface {ECO:0000269|PubMed:8922387}. Cell membrane {ECO:0000269|PubMed:18157949, ECO:0000269|PubMed:21821728, ECO:0000269|PubMed:9600933, ECO:0000305|PubMed:8922387}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q92633}. Endosome {ECO:0000250|UniProtKB:Q92633, ECO:0000305|PubMed:18157949}. Note=Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment (PubMed:18157949). Colocalizes with RALA in endocytic vesicles after LPA treatment. {ECO:0000250|UniProtKB:Q92633, ECO:0000269|PubMed:18157949}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..75; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q92633"; TRANSMEM 84..107; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q92633"; TRANSMEM 122..144; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q92633"; TRANSMEM 164..184; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q92633"; TRANSMEM 205..225; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q92633"; TRANSMEM 256..280; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q92633"; TRANSMEM 295..315; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q92633
uniprot
proteins