Agbl2
entrez
271813
canonical
uniprot
Q8CDK2
canonical
ensembl
ENSMUSG00000040812
resolver
ensp
ENSMUSP00000047936
resolver
ensp
ENSMUSP00000048647
resolver
ensp
ENSMUSP00000115632
resolver
ensp
ENSMUSP00000129216
resolver
ensp
ENSMUSP00000203601
resolver
genesymbol
Agbl2
resolver
genesymbol_syn
Ccp2
resolver
uniprot
A2AH35
resolver
uniprot
Q09M08
resolver
uniprot
Q09M09
resolver
uniprot
Q09M10
resolver
uniprot
Q09M11
resolver
uniprot
Q09M12
resolver
uniprot
Q8C529
resolver
uniprot
Q8C9X4
resolver
uniprot
Q8CDE6
resolver
uniprot
Q8CDF6
resolver
uniprot
Q8CDQ1
resolver
uniprot_entry
CBPC2_MOUSE
resolver
uniprot_sec
A2AH35
resolver
uniprot_sec
Q09M08
resolver
uniprot_sec
Q09M09
resolver
uniprot_sec
Q09M10
resolver
uniprot_sec
Q09M11
resolver
uniprot_sec
Q09M12
resolver
uniprot_sec
Q8C529
resolver
uniprot_sec
Q8C9X4
resolver
uniprot_sec
Q8CDE6
resolver
uniprot_sec
Q8CDF6
resolver
uniprot_sec
Q8CDQ1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by RARRES1. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MNVLLEMAFLSQTLPDPYEDFIHHHLQYYGYFKAQKSSLPNSGTHQRVWRNSPRYMLNGSFGERDDFISDSLEKEMLLWPTCLSSTGHAHIDAVNRDSLLLSSPLLRTRQLIFDELDEASPRLREPRELFSCFSSRGPLQAPRWPIECEVIKENIHHIEWVPHQPEYFYQPTGSEKVPEIVGEEQGTVVYQLDSVPAEGTYFTSSRIGGKRGTIKELAVTLQGPDDNTLLFESRFESGNLQKAVRVGIYEYELTLRTDLYTDKHTQWFYFRVQNTRKDATYRFTIVNLLKPKSLYAVGMKPLMYSQLDATIYNIGWRREGREIKYYKNNVDDGQQPLYCLTWTTQFPHDQDTCFFAHFYPYTYTDLQCYLLSVANNPIQSQFCKLRALCRSLAGNTVYLLTITNPSRTPQEAAAKKAVVLSARVHPGESNSSWIMNGFLDFILSNSPDAQLLRDIFVFKVIPMLNPDGVIVGNYRCSLAGRDLNRHYKTVLKDSFPCIWYTKNMIKRLLEEREVLLYCDFHGHSRKNNIFLYGCHSNNRKHWLHERVFPLMLSKNAPDKFSFDSCNFKVQKCKEGTGRVVMWRMGIINSYTMESTFGGSTLGSKRDTHFTIEDLKSLGYHVCDTLLDFCDPDQTKYTQCLQELKELLQQEINKKLNNFGQDMDLEGNWSDIPLSDIESSTSGSDSSLSDGPPIRLLNIVADEPNQKTVLKNPKKKRLQTRKQRNEQYQKSYLMRELKLTENAPGRARFVSTLQKQPTFLKSPESPSPSVRRSENPRLNETQLSGREKGTSLDPPLTSPKNKERIQSKKPGFTASCSPKRSTNSSLGPAPDVKPNWSKTRYSATRKDHATMAVYPSLHIYTYP
uniprot
proteins
ec_number
3.4.17.-
uniprot
proteins
function
FUNCTION: Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins (PubMed:25103237). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein (PubMed:25103237). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:25103237). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK (PubMed:25103237). {ECO:0000269|PubMed:25103237}.
uniprot
proteins
mass_dalton
99216
uniprot
proteins
mutagenesis
MUTAGEN 593; /note="E->A: Abolishes deglutamylase activity."; /evidence="ECO:0000269|PubMed:25103237
uniprot
proteins
protein_family
Peptidase M14 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17244818
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25103237
uniprot
proteins
sequence_length
862
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17244818}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q5U5Z8}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q5U5Z8}. Note=Colocalizes with gamma-tubulin in the centrioles and with glutamylated tubulin in the basal bodies of ciliated cells. {ECO:0000250|UniProtKB:Q5U5Z8}.
uniprot
proteins