Sugct
entrez
192136
canonical
uniprot
Q7TNE1
canonical
ensembl
ENSMUSG00000055137
resolver
ensp
ENSMUSP00000070759
resolver
enst
ENSMUST00000068545
resolver
genesymbol
Sugct
resolver
genesymbol_syn
5033411D12Rik
resolver
genesymbol_syn
AF397014
resolver
uniprot
G3X9F8
resolver
uniprot
Q3TV98
resolver
uniprot_entry
Q3TV98_MOUSE
resolver
uniprot_entry
SUCHY_MOUSE
resolver
uniprot_sec
G3X9F8
resolver
amino_acid_sequence
MLWMLARAVAFRRPGRGLAGGRGLWTGRPQSDCDSMKPLEGVRILDLTRVLAGPFATMNLGDLGAEVIKVERPGAGDDTRSWGPPFVNTESTYFLSVNRNKKSIAVNIKDPRGVRIVKELAAICDVFVENYVPGKLSEMGLGYEDIDKIAPHIIYCSITGYGQTGPMSHRAGYDAIASAMSGLMHITGPEDGDPVRPGVAMTDLATGLFAYGAIMAGLLQRYRTGKGLFIDCNLLSSQVACLTQVAANYLIGQKEAKRWGTAHGSIVPYQAFKTKDGYLVIGAGNNQQFAVVCKILNLPELIDDCKYRTNHLRVQNRKELVKILSARFAEEVTAKWLCLFEGSGIPYGPINSLKDVFSEAQVLHNGLVMEMNHPTVGKISVPGPAVRYSKFKMSEAKPPPLLGQHTRHILKEVLRYDEGAIEKLLCSGVIEQHETK
uniprot
proteins
ec_number
2.8.3.-
uniprot
proteins
ec_number
2.8.3.13
uniprot
proteins
function
FUNCTION: Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and glutarate, succinate, adipate/hexanedioate, itaconate and 3-hydroxy-3-methylglutarate as dicarboxylate acceptors (By similarity). Acts on intermediates or end products of lysine and tryptophan degradation pathway, in particular catalyzes succinyl-CoA-dependent reesterification of free glutarate into glutaryl-CoA to prevent renal excretion of glutarate (By similarity). Upon inflammation, may convert macrophage-derived itaconate to itaconyl-CoA in erythroid precursors where it negatively regulates the TCA cycle and heme synthesis to limit erythroid differentiation in the context of stress erythropoiesis (By similarity). {ECO:0000250|UniProtKB:Q9HAC7}.
uniprot
proteins
mass_dalton
47690
uniprot
proteins
protein_family
CoA-transferase III family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
31722069
uniprot
proteins
sequence_length
436
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9HAC7}.
uniprot
proteins