Sdhaf1
entrez
499125
canonical
uniprot
B0K036
canonical
ensembl
ENSRNOG00000047045
resolver
ensembl
ENSRNOG00060033027
resolver
ensembl
ENSRNOG00065034109
resolver
ensp
ENSRNOP00000067764
resolver
ensp
ENSRNOP00060047370
resolver
ensp
ENSRNOP00065048254
resolver
enst
ENSRNOT00000074494
resolver
enst
ENSRNOT00060057294
resolver
enst
ENSRNOT00065058606
resolver
genesymbol
Sdhaf1
resolver
genesymbol_syn
Lyrm8
resolver
uniprot_entry
SDHF1_RAT
resolver
amino_acid_sequence
MSRLSRLQRQVLSLYRELLRAGRGKPGAEARVRAEFRQHASLPRSDVLRIEYLYRRGRRQLQLLRSGHATAMGTFVRPRGPTEEPVDATAPGNRLDDSDALKNPCEGTGARETRSDGR
uniprot
proteins
function
FUNCTION: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit Sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3. Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. {ECO:0000250|UniProtKB:A6NFY7}.
uniprot
proteins
mass_dalton
13312
uniprot
proteins
protein_family
Complex I LYR family
uniprot
proteins
protein_family
SDHAF1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
118
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:A6NFY7}.
uniprot
proteins