RAB11A
entrez
8766
canonical
uniprot
P62491
canonical
ensembl
ENSG00000103769
resolver
ensp
ENSP00000261890
resolver
ensp
ENSP00000456420
resolver
genesymbol
RAB11A
resolver
genesymbol_syn
RAB11
resolver
hgnc
HGNC:9760
resolver
uniprot
B2R4B6
resolver
uniprot
B4DT13
resolver
uniprot
P24410
resolver
uniprot
Q5TZN9
resolver
uniprot
Q9JLX1
resolver
uniprot_entry
RB11A_HUMAN
resolver
uniprot_sec
B2R4B6
resolver
uniprot_sec
B4DT13
resolver
uniprot_sec
P24410
resolver
uniprot_sec
Q5TZN9
resolver
uniprot_sec
Q9JLX1
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including SH3BP5, which promote the exchange of bound GDP for free GTP (PubMed:30217979). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation (Probable). {ECO:0000269|PubMed:30217979, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15601896, PubMed:15689490, PubMed:17462998, PubMed:19542231, PubMed:20026645, PubMed:20890297, PubMed:21282656, PubMed:26032412). RAB11A regulates endocytic recycling (PubMed:20026645). Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). Acts as a major regulator of membrane delivery during cytokinesis (PubMed:15601896). Together with MYO5B and RAB8A participates in epithelial cell polarization (PubMed:21282656). Together with Rabin8/RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells (PubMed:17462998). Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane (PubMed:19542231). Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane (PubMed:15689490). Regulates the recycling of FCGRT (receptor of Fc region of monomeric IgG) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879, PubMed:31204173). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44 (PubMed:32344433). Also interacts with RABL3 to promote ciliary vesicle formation (PubMed:36052645). {ECO:0000250|UniProtKB:P62490, ECO:0000250|UniProtKB:P62492, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:15689490, ECO:0000269|PubMed:17462998, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26032412, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:36052645}.
uniprot
proteins
mass_dalton
24394
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="K->N: Abolishes SH3BP5-mediated guanine nucleotide exchange."; /evidence="ECO:0000269|PubMed:30217979"; MUTAGEN 22; /note="V->M: Impairs protein folding."; /evidence="ECO:0000269|PubMed:30217979"; MUTAGEN 24; /note="K->R: Impairs protein folding and decreases affinity for guanine nucleotides."; /evidence="ECO:0000269|PubMed:30217979"; MUTAGEN 25; /note="S->N: Dominant-negative mutant (GDP-bound form). Induces increased number of binucleated cells, indicating defects in cytokinesis. Inhibits the transport of NPC1L1 to the plama membrane. Disrupts the trafficking of CDH1 to the plasma membrane and promotes accumulation of CDH1 in RAB11A endosomes in nonpolarized cells. Promotes mistargeting of CDH1 to the apical membrane in polarized cells. Increased interaction with ATP9A. Loss of interaction with WDR44, decreased WDR44-positive tubules and loss of E-cadherin export. Decreased colocalizazion with GDP-bound RABL3. Impaired positive regulation of ciliary vesicle formation."; /evidence="ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:15689490, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:30217979, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:36052645, ECO:0000269|PubMed:36604604"; MUTAGEN 36; /note="F->A: Nearly abolishes SH3BP5-mediated guanine nucleotide exchange."; /evidence="ECO:0000269|PubMed:30217979"; MUTAGEN 38; /note="L->A: Decreases SH3BP5-mediated guanine nucleotide exchange."; /evidence="ECO:0000269|PubMed:30217979"; MUTAGEN 38; /note="L->P: Nearly abolishes SH3BP5-mediated guanine nucleotide exchange."; /evidence="ECO:0000269|PubMed:30217979"; MUTAGEN 40; /note="S->F: Nearly abolishes SH3BP5-mediated guanine nucleotide exchange."; /evidence="ECO:0000269|PubMed:30217979"; MUTAGEN 41; /note="K->A: Mildly decreases SH3BP5-mediated guanine nucleotide exchange."; /evidence="ECO:0000269|PubMed:30217979"; MUTAGEN 41; /note="K->P: Abolishes SH3BP5-mediated guanine nucleotide exchange."; /evidence="ECO:0000269|PubMed:30217979"; MUTAGEN 44; /note="I->A: Abolishes SH3BP5-mediated guanine nucleotide exchange."; /evidence="ECO:0000269|PubMed:30217979"; MUTAGEN 70; /note="Q->L: Constitutively active mutant (GTP-bound form). Decreases GTPase activity. Disrupts the trafficking of CDH1 to the plasma membrane and promotes accumulation of CDH1 in RAB11A endosomes in nonpolarized cells. Promotes mistargeting of CDH1 to the apical membrane in polarized cells. Increased colocalizazion with GDP-bound RABL3."; /evidence="ECO:0000269|PubMed:15689490, ECO:0000269|PubMed:15837192, ECO:0000269|PubMed:16905101, ECO:0000269|PubMed:17007872, ECO:0000269|PubMed:17030804, ECO:0000269|PubMed:30217979, ECO:0000269|PubMed:36052645"; MUTAGEN 82; /note="R->C: Decreases SH3BP5-mediated guanine nucleotide exchange."; /evidence="ECO:0000269|PubMed:30217979"; MUTAGEN 154; /note="S->L: Impairs protein folding."; /evidence="ECO:0000269|PubMed:30217979
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3. {ECO:0000269|PubMed:32974215}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10077598
uniprot
proteins
pubmed
11495908
uniprot
proteins
pubmed
11786538
uniprot
proteins
pubmed
11994279
uniprot
proteins
pubmed
12470645
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15173169
uniprot
proteins
pubmed
15181150
uniprot
proteins
pubmed
15280022
uniprot
proteins
pubmed
15304524
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15601896
uniprot
proteins
pubmed
15689490
uniprot
proteins
pubmed
15837192
uniprot
proteins
pubmed
16034420
uniprot
proteins
pubmed
16148947
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
16905101
uniprot
proteins
pubmed
17007872
uniprot
proteins
pubmed
17030804
uniprot
proteins
pubmed
1704119
uniprot
proteins
pubmed
17082457
uniprot
proteins
pubmed
17229837
uniprot
proteins
pubmed
17462998
uniprot
proteins
pubmed
18329369
uniprot
proteins
pubmed
19542231
uniprot
proteins
pubmed
20026645
uniprot
proteins
pubmed
20028792
uniprot
proteins
pubmed
20190753
uniprot
proteins
pubmed
20890297
uniprot
proteins
pubmed
21255211
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21282656
uniprot
proteins
pubmed
21976701
uniprot
proteins
pubmed
22613832
uniprot
proteins
pubmed
23535298
uniprot
proteins
pubmed
24023390
uniprot
proteins
pubmed
25673879
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26032412
uniprot
proteins
pubmed
26258637
uniprot
proteins
pubmed
26506309
uniprot
proteins
pubmed
28017832
uniprot
proteins
pubmed
28384198
uniprot
proteins
pubmed
29514088
uniprot
proteins
pubmed
29514919
uniprot
proteins
pubmed
30217979
uniprot
proteins
pubmed
31204173
uniprot
proteins
pubmed
31308374
uniprot
proteins
pubmed
31578334
uniprot
proteins
pubmed
32344433
uniprot
proteins
pubmed
32974215
uniprot
proteins
pubmed
36052645
uniprot
proteins
pubmed
36604604
uniprot
proteins
pubmed
9662449
uniprot
proteins
sequence_length
216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15304524}; Lipid-anchor {ECO:0000305|PubMed:24023390}. Endosome membrane {ECO:0000269|PubMed:32344433}; Lipid-anchor {ECO:0000305|PubMed:24023390}. Recycling endosome membrane {ECO:0000269|PubMed:11994279, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:29514919}; Lipid-anchor {ECO:0000305|PubMed:24023390}. Cleavage furrow {ECO:0000269|PubMed:15601896}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:21255211}; Lipid-anchor {ECO:0000305|PubMed:24023390}. Golgi apparatus membrane {ECO:0000269|PubMed:25673879}; Lipid-anchor {ECO:0000305|PubMed:24023390}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:25673879}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:26032412, ECO:0000269|PubMed:30217979}; Lipid-anchor {ECO:0000305|PubMed:24023390}. Cell projection, cilium {ECO:0000269|PubMed:29514088}. Note=Localized to WDR44-positive endosomes and tubules (PubMed:32344433). Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:11994279). During interphase, localized in vesicles continuously moving from peripheral sorting endosomes towards the pericentrosomal ERC (PubMed:20026645). Localizes to the cleavage furrow (PubMed:15601896). Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). Localized to rhodopsin transport carriers when interacting with RAB11AFIP3 and ASAP1 in photoreceptors (PubMed:25673879). Colocalizes with RAB11AFIP1 on punctate vesicles (PubMed:26032412). {ECO:0000269|PubMed:11994279, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26032412, ECO:0000269|PubMed:32344433}.
uniprot
proteins