GABPB1
entrez
2553
canonical
uniprot
Q06547
canonical
ensembl
ENSG00000104064
resolver
ensp
ENSP00000220429
resolver
ensp
ENSP00000351923
resolver
ensp
ENSP00000370259
resolver
ensp
ENSP00000379728
resolver
ensp
ENSP00000395771
resolver
ensp
ENSP00000571132
resolver
ensp
ENSP00000571133
resolver
ensp
ENSP00000571138
resolver
ensp
ENSP00000571143
resolver
ensp
ENSP00000616563
resolver
ensp
ENSP00000616565
resolver
genesymbol
GABPB1
resolver
genesymbol_syn
E4TF1B
resolver
genesymbol_syn
GABPB
resolver
genesymbol_syn
GABPB2
resolver
hgnc
HGNC:4074
resolver
uniprot
A8IE52
resolver
uniprot
Q06545
resolver
uniprot
Q12940
resolver
uniprot
Q12941
resolver
uniprot
Q12942
resolver
uniprot
Q8IYD0
resolver
uniprot_entry
GABP1_HUMAN
resolver
uniprot_sec
A8IE52
resolver
uniprot_sec
Q06545
resolver
uniprot_sec
Q12940
resolver
uniprot_sec
Q12941
resolver
uniprot_sec
Q12942
resolver
uniprot_sec
Q8IYD0
resolver
amino_acid_sequence
MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREALQKQLDEANREAQKYRQQLLKKEQEAEAYRQKLEAMTRLQTNKEAV
uniprot
proteins
function
FUNCTION: Transcription factor capable of interacting with purine rich repeats (GA repeats) (PubMed:10675337, PubMed:8441384, PubMed:8816484). Acts as a master regulator of nuclear-encoded mitochondrial genes (By similarity). {ECO:0000250|UniProtKB:Q00420, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:8441384, ECO:0000269|PubMed:8816484}.; FUNCTION: (Microbial infection) Necessary for the expression of the Adenovirus E4 gene. {ECO:0000269|PubMed:8441384}.
uniprot
proteins
mass_dalton
42483
uniprot
proteins
mutagenesis
MUTAGEN 262..263; /note="QQ->AA: Minor reduction in transcriptional activation; when associated with A-295 or A-305 and A-306."; /evidence="ECO:0000269|PubMed:8816484"; MUTAGEN 264..265; /note="VV->AA: Minor effect upon interaction with HCFC1 and transcriptional activation. Loss of activity; when associated with A-297; A-298 and A-299, or with A-307 and A-310."; /evidence="ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:8816484"; MUTAGEN 270..271; /note="QQ->AA: Minor reduction in transcriptional activation. Moderate reduction in activity; when associated with A-305 and A-306."; /evidence="ECO:0000269|PubMed:8816484"; MUTAGEN 273..275; /note="ITI->ATA: Strongly reduces interaction with HCFC1 and transcriptional activation. Loss of activity; when associated with A-297; A-298 and A-299, or with A-307 and A-310."; /evidence="ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:8816484"; MUTAGEN 295; /note="Q->A: No effect on transcriptional activation. Minor reduction in activity; when associated with A-270 and A-271."; /evidence="ECO:0000269|PubMed:8816484"; MUTAGEN 297..299; /note="IIV->AAA: Strongly reduces interaction with HCFC1 and transcriptional activation. Loss of activity; when associated with A-264 and A-265, or A-273 and A-275."; /evidence="ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:8816484"; MUTAGEN 305..306; /note="QQ->AA: Minor reduction in transcriptional activation. Moderate reduction in activity; when associated with A-270 and A-271."; /evidence="ECO:0000269|PubMed:8816484"; MUTAGEN 307..310; /note="VLTV->ALTA: Moderately reduces interaction with HCFC1 and transcriptional activation. Loss of activity; when associated with A-273 and A-275."; /evidence="ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:8816484
uniprot
proteins
post_translational_modification
PTM: Acetylated by EP300/p300. Deacetylated by SIRT7, promoting heterotetramerization and activity. {ECO:0000250|UniProtKB:Q00420}.
uniprot
proteins
pubmed
10675337
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
7799916
uniprot
proteins
pubmed
7918435
uniprot
proteins
pubmed
8383622
uniprot
proteins
pubmed
8441384
uniprot
proteins
pubmed
8816484
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:7799916, ECO:0000305|PubMed:8441384}.
uniprot
proteins