IGFBP1
entrez
3484
canonical
uniprot
P08833
canonical
ensembl
ENSG00000146678
resolver
ensp
ENSP00000275525
resolver
enst
ENST00000275525
resolver
genesymbol
IGFBP1
resolver
genesymbol_syn
IBP1
resolver
hgnc
HGNC:5469
resolver
uniprot
A4D2F4
resolver
uniprot
D3DVL9
resolver
uniprot
Q8IYP5
resolver
uniprot_entry
IBP1_HUMAN
resolver
uniprot_sec
A4D2F4
resolver
uniprot_sec
D3DVL9
resolver
uniprot_sec
Q8IYP5
resolver
amino_acid_sequence
MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN
uniprot
proteins
function
FUNCTION: Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner (PubMed:11397844, PubMed:15972819). Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif (PubMed:7504269). Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:11397844). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (By similarity). {ECO:0000250|UniProtKB:P21743, ECO:0000269|PubMed:11397844, ECO:0000269|PubMed:15972819, ECO:0000269|PubMed:3419931, ECO:0000269|PubMed:7504269}.
uniprot
proteins
mass_dalton
27904
uniprot
proteins
mutagenesis
MUTAGEN 246; /note="R->W: Loss of binding to ITGA5."; /evidence="ECO:0000269|PubMed:7504269
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis. {ECO:0000269|PubMed:15972819, ECO:0000269|PubMed:19765076, ECO:0000269|PubMed:7678248}.
uniprot
proteins
pubmed
10329650
uniprot
proteins
pubmed
11397844
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
1373120
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15972819
uniprot
proteins
pubmed
16924115
uniprot
proteins
pubmed
1718783
uniprot
proteins
pubmed
19765076
uniprot
proteins
pubmed
21892205
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2454104
uniprot
proteins
pubmed
2457513
uniprot
proteins
pubmed
2458522
uniprot
proteins
pubmed
2461294
uniprot
proteins
pubmed
2466665
uniprot
proteins
pubmed
2474129
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
2849945
uniprot
proteins
pubmed
2971653
uniprot
proteins
pubmed
3419931
uniprot
proteins
pubmed
38246959
uniprot
proteins
pubmed
7504269
uniprot
proteins
pubmed
7678248
uniprot
proteins
pubmed
7679979
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:38246959}.
uniprot
proteins