Nr4a1
entrez
15370
canonical
uniprot
P12813
canonical
ensembl
ENSMUSG00000023034
resolver
ensp
ENSMUSP00000023779
resolver
ensp
ENSMUSP00000155225
resolver
ensp
ENSMUSP00000177822
resolver
ensp
ENSMUSP00000177827
resolver
ensp
ENSMUSP00000177838
resolver
ensp
ENSMUSP00000345828
resolver
enst
ENSMUST00000023779
resolver
enst
ENSMUST00000228985
resolver
genesymbol
Nr4a1
resolver
genesymbol_syn
Gfrp
resolver
genesymbol_syn
Hmr
resolver
genesymbol_syn
N10
resolver
genesymbol_syn
Nur77
resolver
uniprot
Q545Q1
resolver
uniprot_entry
NR4A1_MOUSE
resolver
uniprot_entry
Q545Q1_MOUSE
resolver
amino_acid_sequence
MPCIQAQYGTPATSPGPRDHLTGDPLALEFGKPTMDLASPETAPAAPATLPSFSTFMDGYTGEFDTFLYQLPGTTQPCSSACSSASSTSSSSSSATSPASASFKFEDFQVYGCYPGTLSGPLDETLSSSGSEYYGSPCSAPSPSTPNFQPSQLSPWDGSFGHFSPSQTYEGLWAWTEQLPKASSGPPPPPTFFSFSPPTGPSPSLAQSSLKLFPPPATHQLGEGESYSMPAAFPGLAPTSPNRDTSGILDAPVTSTKSRSGASGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKSAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPTNLLTSLIRAHLDSGPSTAKLDYSKFQELVLPRFGKEDAGDVQQFYDLLSGSLDVIRKWAEKIPGFIELCPGDQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHQLQCARGFGDWIDNILAFSRSLHSLGVDVPAFACLSALVLITDRHGLQDPRRVEELQNRIASCLKEHMATVAGDPQPASCLSRLLGKLPELRTLCTQGLQRIFCLKLEDLVPPPPIVDKIFMDTLSF
uniprot
proteins
function
FUNCTION: Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:37001519). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (By similarity). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (PubMed:30134173). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:30134173). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (PubMed:22427340). {ECO:0000250|UniProtKB:P22736, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:22427340, ECO:0000269|PubMed:30134173, ECO:0000269|PubMed:37001519}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000269|PubMed:37001519}.
uniprot
proteins
mass_dalton
64738
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-354 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli. {ECO:0000250}.; PTM: Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
NR4 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18690216
uniprot
proteins
pubmed
22427340
uniprot
proteins
pubmed
2555161
uniprot
proteins
pubmed
30134173
uniprot
proteins
pubmed
3186734
uniprot
proteins
pubmed
37001519
uniprot
proteins
sequence_length
601
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:2555161, ECO:0000269|PubMed:30134173}. Cytoplasm, cytosol {ECO:0000269|PubMed:37001519}. Mitochondrion {ECO:0000250|UniProtKB:P22736}. Note=Nuclear export to the cytosol is XPO1-mediated and positively regulated by IFI27. Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (By similarity). {ECO:0000250|UniProtKB:P22736}.
uniprot
proteins