SLC29A2
entrez
3177
canonical
uniprot
Q14542
canonical
ensembl
ENSG00000174669
resolver
ensp
ENSP00000311250
resolver
ensp
ENSP00000350024
resolver
ensp
ENSP00000440329
resolver
ensp
ENSP00000543700
resolver
ensp
ENSP00000713114
resolver
genesymbol
SLC29A2
resolver
genesymbol_syn
DER12
resolver
genesymbol_syn
ENT2
resolver
genesymbol_syn
HNP36
resolver
hgnc
HGNC:11004
resolver
uniprot
B3KPY7
resolver
uniprot
G5E943
resolver
uniprot
O43530
resolver
uniprot
Q52M84
resolver
uniprot
Q96FB2
resolver
uniprot
Q96R00
resolver
uniprot
Q9UPE0
resolver
uniprot_entry
Q96FB2_HUMAN
resolver
uniprot_entry
S29A2_HUMAN
resolver
uniprot_sec
B3KPY7
resolver
uniprot_sec
G5E943
resolver
uniprot_sec
O43530
resolver
uniprot_sec
Q52M84
resolver
uniprot_sec
Q96R00
resolver
uniprot_sec
Q9UPE0
resolver
amino_acid_sequence
MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTGPEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVDMSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLLSMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAELLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLVFTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRLLPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPRQVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL
uniprot
proteins
function
FUNCTION: Bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:12527552, PubMed:12590919, PubMed:16214850, PubMed:21795683, PubMed:9396714, PubMed:9478986). Functions as a Na(+)-independent, passive transporter (PubMed:9478986). Involved in the transport of nucleosides such as inosine, adenosine, uridine, thymidine, cytidine and guanosine (PubMed:10722669, PubMed:12527552, PubMed:12590919, PubMed:16214850, PubMed:21795683, PubMed:9396714, PubMed:9478986). Also able to transport purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:16214850, PubMed:21795683). Also mediates nicotinamide uptake supporting homeostasis and modulating its biological activities (PubMed:39885119). Can also transport urate (PubMed:40367900). Involved in nucleoside transport at basolateral membrane of kidney cells, allowing liver absorption of nucleoside metabolites (PubMed:12527552). Mediates apical nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier (PubMed:23639800). Mediates both the influx and efflux of hypoxanthine in skeletal muscle microvascular endothelial cells to control the amount of intracellular hypoxanthine available for xanthine oxidase-mediated ROS production (By similarity). {ECO:0000250|UniProtKB:O54699, ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:12590919, ECO:0000269|PubMed:16214850, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:39885119, ECO:0000269|PubMed:40367900, ECO:0000269|PubMed:9396714, ECO:0000269|PubMed:9478986}.; FUNCTION: [Isoform 3]: Non functional nucleoside transporter protein for adenosine or thymidine transport. Does not express on cell membrane. {ECO:0000269|PubMed:12527552}.
uniprot
proteins
mass_dalton
50113
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="N->D: No difference in uridine or cytidine uptake. No differences in Km values and lower Vmax values for either uridine or cytidine uptake; when associated with D-57."; /evidence="ECO:0000269|PubMed:12590919"; MUTAGEN 57; /note="N->D: No difference in uridine or cytidine uptake. No differences in Km values and lower Vmax values for either uridine or cytidine uptake; when associated with D-48."; /evidence="ECO:0000269|PubMed:12590919"; MUTAGEN 455; /note="L->R: Reduces drastically localization at the cell surface. No effect on uptake of adenosine and thymidine. Reduces drastically localization at the cell surface and induces an significant reduction of adenosine or thymidine uptake; when associated with R-456."; /evidence="ECO:0000269|PubMed:12527552"; MUTAGEN 456; /note="L->R: Reduces drastically localization at the cell surface and induces an significant reduction of adenosine or thymidine uptake; when associated with R-455."; /evidence="ECO:0000269|PubMed:12527552
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:12590919}.
uniprot
proteins
protein_family
SLC29A/ENT transporter (TC 2.A.57) family
uniprot
proteins
pubmed
10722669
uniprot
proteins
pubmed
12527552
uniprot
proteins
pubmed
12590919
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16214850
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21795683
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23639800
uniprot
proteins
pubmed
27271752
uniprot
proteins
pubmed
39885119
uniprot
proteins
pubmed
40367900
uniprot
proteins
pubmed
7639753
uniprot
proteins
pubmed
9396714
uniprot
proteins
pubmed
9478986
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:23639800}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:12527552}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:40367900}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the apical membrane of Sertoli cells. {ECO:0000269|PubMed:23639800}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 70..90; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 99..119; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 124..144; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 162..182; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 291..311; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 324..344; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 360..380; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 386..406; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 432..452; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins