Mettl2
entrez
52686
canonical
uniprot
Q8BMK1
canonical
ensembl
ENSMUSG00000020691
resolver
ensp
ENSMUSP00000021030
resolver
ensp
ENSMUSP00000225921
resolver
ensp
ENSMUSP00000225932
resolver
genesymbol
Mettl2
resolver
genesymbol_syn
D11Ertd768e
resolver
uniprot
Q3U5T7
resolver
uniprot
Q5EBH8
resolver
uniprot
Q8BXC2
resolver
uniprot_entry
METL2_MOUSE
resolver
uniprot_sec
Q3U5T7
resolver
uniprot_sec
Q5EBH8
resolver
uniprot_sec
Q8BXC2
resolver
amino_acid_sequence
MAASFPEGVPETEDGKRPQFGHRFLSDPARVFHHNAWDNVKWSEEQAAAAERKVQENSSPLVCPEKQVDYEVNAHKYWDDFYRIHENGFFKDRHWLFTEFPELAPSHSHLTGVPLEKQRSDVCEDGPGLTAEQHKCSCASPGCETQVPPLEEPVTQKLGHLEISGEEFPGSSATYRILEVGCGVGNTVFPILQTNNNPNLFVYCCDFSATAIELLKTNSQYDPSRCYAFVHDLCDEDQSYPVPEDSLDVIVLIFVLSAIVPDKMQKAISKLSRLLKPGGVMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQGELDTLFTAAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYSKPLALRSSQHVPIPHATESSSHSGLL
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767). N(3)-methylcytidine methylation by METTL2 requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (By similarity). {ECO:0000250|UniProtKB:Q96IZ6, ECO:0000269|PubMed:28655767}.
uniprot
proteins
mass_dalton
43912
uniprot
proteins
protein_family
METL family
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
28655767
uniprot
proteins
sequence_length
389
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96IZ6}.
uniprot
proteins