NCK1
entrez
4690
canonical
uniprot
P16333
canonical
ensembl
ENSG00000158092
resolver
ensp
ENSP00000288986
resolver
ensp
ENSP00000417273
resolver
ensp
ENSP00000419631
resolver
ensp
ENSP00000568774
resolver
ensp
ENSP00000568779
resolver
ensp
ENSP00000568780
resolver
genesymbol
NCK1
resolver
genesymbol_syn
NCK
resolver
hgnc
HGNC:7664
resolver
uniprot
A0A0S2Z4Y3
resolver
uniprot
B7Z751
resolver
uniprot
D3DNE3
resolver
uniprot_entry
A0A0S2Z4Y3_HUMAN
resolver
uniprot_entry
NCK1_HUMAN
resolver
uniprot_sec
B7Z751
resolver
uniprot_sec
D3DNE3
resolver
amino_acid_sequence
MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAPIFTSEQGEKLYLVKHLS
uniprot
proteins
function
FUNCTION: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}.
uniprot
proteins
mass_dalton
42864
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="W->K: Small decrease in RASA1-binding. Almost complete loss of RASA1-binding; when associated with K-143 and K-229."; /evidence="ECO:0000269|PubMed:21664272"; MUTAGEN 143; /note="W->K: No effect on RASA1-binding. Almost complete loss of RASA1-binding; when associated with K-38 and K-229."; /evidence="ECO:0000269|PubMed:21664272"; MUTAGEN 229; /note="W->K: Small decrease in RASA1-binding. Almost complete loss of RASA1-binding; when associated with K-38 and K-229."; /evidence="ECO:0000269|PubMed:21664272"; MUTAGEN 308; /note="R->K: No effect on RASA1-binding."; /evidence="ECO:0000269|PubMed:21664272
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser and Tyr residues. Phosphorylated in response to activation of EGFR and FcERI. Phosphorylated by activated PDGFRB. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:1333046, ECO:0000269|PubMed:1448108, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:7692233}.
uniprot
proteins
pubmed
10026169
uniprot
proteins
pubmed
10747847
uniprot
proteins
pubmed
12091389
uniprot
proteins
pubmed
1333046
uniprot
proteins
pubmed
1448108
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15469942
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15504032
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16835242
uniprot
proteins
pubmed
16966330
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17803907
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18269246
uniprot
proteins
pubmed
18296648
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18835251
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19807924
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
2107526
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21664272
uniprot
proteins
pubmed
21707536
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23358419
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7692233
uniprot
proteins
pubmed
8265614
uniprot
proteins
pubmed
9344857
uniprot
proteins
pubmed
9430661
uniprot
proteins
pubmed
9600074
uniprot
proteins
pubmed
9697839
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.
uniprot
proteins