Arfip1
entrez
60382
canonical
uniprot
Q9JHU5
canonical
ensembl
ENSRNOG00000010533
resolver
ensp
ENSRNOP00000014236
resolver
ensp
ENSRNOP00000089444
resolver
enst
ENSRNOT00000014236
resolver
genesymbol
Arfip1
resolver
uniprot
A0A8L2Q6T7
resolver
uniprot_entry
A0A8L2Q6T7_RAT
resolver
uniprot_entry
ARFP1_RAT
resolver
amino_acid_sequence
MAEESPKNSAAEIPVTSNGEVGDAHEHGYNRDLKHSLPSGLGLSETQITSHGFDSTKEGVTEAGASQGSSAPPLPCVLSPSRVAASQLTQHAGGQRTHTKGGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQKQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYENARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQIHKEKYDKMRSDVSVKLKFLEENKVKVLRNQLALFHSAVAAYFAGNQKQLEQTLKQFHVKLKTPGVDAPSWLEEQ
uniprot
proteins
function
FUNCTION: Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells. {ECO:0000250|UniProtKB:P53367}.
uniprot
proteins
mass_dalton
40779
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:P53367}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P53367}.
uniprot
proteins