Htr2a
entrez
29595
canonical
uniprot
P14842
canonical
ensembl
ENSRNOG00000010063
resolver
ensembl
ENSRNOG00055014961
resolver
ensembl
ENSRNOG00060016970
resolver
ensembl
ENSRNOG00065008875
resolver
ensp
ENSRNOP00000013408
resolver
ensp
ENSRNOP00055020859
resolver
ensp
ENSRNOP00060023352
resolver
ensp
ENSRNOP00065010601
resolver
enst
ENSRNOT00000013408
resolver
enst
ENSRNOT00055025574
resolver
enst
ENSRNOT00060029001
resolver
enst
ENSRNOT00065014166
resolver
genesymbol
Htr2a
resolver
genesymbol_syn
Htr2
resolver
uniprot_entry
5HT2A_RAT
resolver
activity_regulation
ACTIVITY REGULATION: G protein-coupled receptor activity is regulated by lipids: oleamide increases HTR2A-mediated activity. {ECO:0000250|UniProtKB:P28223}.
uniprot
proteins
amino_acid_sequence
MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:2300586, PubMed:2854054). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (By similarity). Affects neural activity, perception, cognition and mood (By similarity). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances (By similarity). Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity). {ECO:0000250|UniProtKB:P28223, ECO:0000250|UniProtKB:P35363, ECO:0000269|PubMed:2300586, ECO:0000269|PubMed:2854054}.
uniprot
proteins
mass_dalton
52850
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11960784
uniprot
proteins
pubmed
1765383
uniprot
proteins
pubmed
2300586
uniprot
proteins
pubmed
2854054
uniprot
proteins
sequence_length
471
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11960784, ECO:0000269|PubMed:2300586, ECO:0000269|PubMed:2854054}; Multi-pass membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:11960784}. Cytoplasmic vesicle {ECO:0000269|PubMed:11960784}. Membrane, caveola {ECO:0000269|PubMed:11960784}. Cell projection, dendrite {ECO:0000250|UniProtKB:P35363}. Presynapse {ECO:0000269|PubMed:11960784}.
uniprot
proteins
transmembrane_region
TRANSMEM 81..97; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P28223"; TRANSMEM 112..137; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P28223"; TRANSMEM 147..171; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P28223"; TRANSMEM 192..215; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P28223"; TRANSMEM 233..258; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P28223"; TRANSMEM 323..348; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P28223"; TRANSMEM 357..382; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P28223
uniprot
proteins