PSMB6
entrez
5694
canonical
uniprot
P28072
canonical
ensembl
ENSG00000142507
resolver
ensp
ENSP00000270586
resolver
ensp
ENSP00000485006
resolver
enst
ENST00000270586
resolver
enst
ENST00000614486
resolver
genesymbol
PSMB6
resolver
genesymbol_syn
LMPY
resolver
genesymbol_syn
Y
resolver
hgnc
HGNC:9543
resolver
uniprot
A0A087X2I4
resolver
uniprot
Q6IAT9
resolver
uniprot
Q96J55
resolver
uniprot_entry
A0A087X2I4_HUMAN
resolver
uniprot_entry
PSB6_HUMAN
resolver
uniprot_entry
Q6IAT9_HUMAN
resolver
uniprot_sec
Q96J55
resolver
amino_acid_sequence
MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA
uniprot
proteins
ec_number
3.4.25.1
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolyzing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues. {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
uniprot
proteins
mass_dalton
25358
uniprot
proteins
protein_family
Peptidase T1B family
uniprot
proteins
pubmed
12181345
uniprot
proteins
pubmed
14550573
uniprot
proteins
pubmed
15244466
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15613457
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
1888762
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
2306472
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23495936
uniprot
proteins
pubmed
25599644
uniprot
proteins
pubmed
26133119
uniprot
proteins
pubmed
27176742
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
27493187
uniprot
proteins
pubmed
34711951
uniprot
proteins
pubmed
8066462
uniprot
proteins
pubmed
8163024
uniprot
proteins
pubmed
8610016
uniprot
proteins
sequence_length
239
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
uniprot
proteins