PMM1
entrez
5372
canonical
uniprot
Q92871
canonical
ensembl
ENSG00000100417
resolver
ensp
ENSP00000216259
resolver
ensp
ENSP00000566678
resolver
ensp
ENSP00000610529
resolver
ensp
ENSP00000619595
resolver
ensp
ENSP00000619598
resolver
enst
ENST00000216259
resolver
enst
ENST00000949536
resolver
genesymbol
PMM1
resolver
genesymbol_syn
PMMH22
resolver
hgnc
HGNC:9114
resolver
uniprot
A8K003
resolver
uniprot
Q92586
resolver
uniprot_entry
PMM1_HUMAN
resolver
uniprot_sec
A8K003
resolver
uniprot_sec
Q92586
resolver
activity_regulation
ACTIVITY REGULATION: IMP, a metabolite whose concentration is elevated in anoxia, inhibits phosphomannomutase and phosphoglucomutase activities and strongly enhances glucose-1,6-bisphosphatase activity. {ECO:0000250|UniProtKB:O35621}.
uniprot
proteins
amino_acid_sequence
MAVTAQAARRKERVLCLFDVDGTLTPARQKIDPEVAAFLQKLRSRVQIGVVGGSDYCKIAEQLGDGDEVIEKFDYVFAENGTVQYKHGRLLSKQTIQNHLGEELLQDLINFCLSYMALLRLPKKRGTFIEFRNGMLNISPIGRSCTLEERIEFSELDKKEKIREKFVEALKTEFAGKGLRFSRGGMISFDVFPEGWDKRYCLDSLDQDSFDTIHFFGNETSPGGNDFEIFADPRTVGHSVVSPQDTVQRCREIFFPETAHEA
uniprot
proteins
ec_number
5.4.2.8
uniprot
proteins
function
FUNCTION: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. {ECO:0000269|PubMed:16540464}.
uniprot
proteins
mass_dalton
29747
uniprot
proteins
pathway_participation
PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.
uniprot
proteins
protein_family
Eukaryotic PMM family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16540464
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
29695157
uniprot
proteins
pubmed
9070917
uniprot
proteins
pubmed
9119384
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O35621}.
uniprot
proteins