Q9CRT8
uniprot
Q9CRT8
canonical
amino_acid_sequence
MDEQALLGLNPNADSDFRQRALAYFEQLKISPDAWQVCAEALAQKTYSDDHVKFFCFQVLEHQVKYKYSELSTAQQQLIRETLLSWLQAQMQNPQPEKTFIRNKAAQVFALLFVTEYLTKWPKFFFDILSVVDLNPRGVDLYLRILMAIDSELVDRDVVHTSEASGLENTLIKDTMREQCIPNLVESWYQILHNYQYTNSEVLCQCLEVVGAYVSWIDLSLIANDRFINMLLGHMSVEVLREEACDCLFEIVNKGMDPVDKMKLVESLCQVLQTAGFFSIDQEEDLDFVARFSKLVNGMGQSLIVSWTKLIKNGAVKNAQEALEAIETKVPLMLQLLVHEDDDISSNIIGFCYDYLHILKQLPVLSDQQKANVEAIMLAVMKKLTYDEEYNFENEGEDEAMFVEYRKQLKLLLDRLAQVSPELVLASVRRVFSATLQNWQTTRFMEVEVAVRLLYMLAEALPVSHGAHFSGDVSKASALQDMMRTLVTSGVSSYQHTSVTLEFFETVVRYEKFFTVEPQHIPCVLMAFLDHRGLWHSSAKVRSRTAYLFSRFVKSLNKQMNPYIEEILNRIQDLLALSPPENGYQSLLSSDDQLFIYETAGALIVNSEYPAENKQALMKDLLTPLMERFKVLLEKLMMAQDEERQASLADSLNHAVGFASRTSKAFSNKQTVKQCGCSQVYLDCLQTFLPALSCPLQKDVLRSGVRTFLHRMIICLEEEVLPFIPSASEHMLKDCEAKDLQEFIPLINQITAKFKMQVSPFLQQMFMPLLHAIFEVLLRPAEDNDQSAALEKQMLRRSYFAFLQTVTGSGMSEVIANQGAENVEQVLVTIIQGAVDYPDPIAQKTCFIILSKLVELWGGKDGPVGFADFVYKHIVPACFLAPLKQTFDLADAQTVLALSECAVTLKTIHLKRGPECVQYLQQEYLPSLQVAPEIIQEFCQALQQPDAKVFKNYLKVFFQRAKP
uniprot
proteins
function
FUNCTION: Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
109734
uniprot
proteins
protein_family
Exportin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
963
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm (By similarity). {ECO:0000250}.
uniprot
proteins