KCNA5
entrez
3741
canonical
uniprot
P22460
canonical
ensembl
ENSG00000130037
resolver
ensp
ENSP00000252321
resolver
genesymbol
KCNA5
resolver
hgnc
HGNC:6224
resolver
uniprot
Q4KKT8
resolver
uniprot
Q4VAJ1
resolver
uniprot
Q4VAJ2
resolver
uniprot
Q9UDA4
resolver
uniprot_entry
KCNA5_HUMAN
resolver
uniprot_sec
Q4KKT8
resolver
uniprot_sec
Q4VAJ1
resolver
uniprot_sec
Q4VAJ2
resolver
uniprot_sec
Q9UDA4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 4-aminopyridine, nicotine, bepridil, correolide, and endothelin-1. {ECO:0000269|PubMed:17267549, ECO:0000269|PubMed:20018952}.
uniprot
proteins
amino_acid_sequence
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
uniprot
proteins
disease_involvement
DISEASE: Atrial fibrillation, familial, 7 (ATFB7) [MIM:612240]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO:0000269|PubMed:16772329}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:12130714, PubMed:8505626). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). May play a role in regulating the secretion of insulin in normal pancreatic islets. {ECO:0000250|UniProtKB:Q61762, ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:17267549, ECO:0000269|PubMed:20018952, ECO:0000269|PubMed:36917789, ECO:0000269|PubMed:8505626}.; FUNCTION: [Isoform 2]: Exhibits a faster depolarization rate, reduced voltage-dependent recovery from inactivation and an excessive cumulative inactivation. {ECO:0000269|PubMed:11524461}.
uniprot
proteins
mass_dalton
67228
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="T->A: Loss of DLG1 effect on channel current."; /evidence="ECO:0000269|PubMed:16466689"; MUTAGEN 220; /note="I->N: Reduces sumoylation; when associated with N-535."; /evidence="ECO:0000269|PubMed:17261810"; MUTAGEN 221; /note="K->R: Abolishes sumoylation; when associated with R-536."; /evidence="ECO:0000269|PubMed:17261810"; MUTAGEN 535; /note="L->N: Reduces sumoylation; when associated with N-220."; /evidence="ECO:0000269|PubMed:17261810"; MUTAGEN 536; /note="K->R: Abolishes sumoylation; when associated with R-221."; /evidence="ECO:0000269|PubMed:17261810
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:20018952, ECO:0000269|PubMed:36917789}.; PTM: Sumoylated on Lys-221, and Lys-536, preferentially with SUMO3. Sumoylation regulates the voltage sensitivity of the channel. {ECO:0000269|PubMed:17261810}.
uniprot
proteins
protein_family
A (Shaker) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv1.5/KCNA5 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
11524461
uniprot
proteins
pubmed
12130714
uniprot
proteins
pubmed
1349297
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16466689
uniprot
proteins
pubmed
16772329
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17261810
uniprot
proteins
pubmed
17267549
uniprot
proteins
pubmed
1986382
uniprot
proteins
pubmed
2001794
uniprot
proteins
pubmed
20018952
uniprot
proteins
pubmed
24936649
uniprot
proteins
pubmed
33007923
uniprot
proteins
pubmed
36917789
uniprot
proteins
pubmed
8505626
uniprot
proteins
sequence_length
613
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:20018952, ECO:0000269|PubMed:8505626}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 248..269; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 324..345; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 357..377; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 396..416; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 432..453; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 495..523; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:P63142
uniprot
proteins