NMI
entrez
9111
canonical
uniprot
Q13287
canonical
ensembl
ENSG00000123609
resolver
ensp
ENSP00000243346
resolver
ensp
ENSP00000553716
resolver
ensp
ENSP00000553718
resolver
ensp
ENSP00000553719
resolver
enst
ENST00000243346
resolver
enst
ENST00000883657
resolver
enst
ENST00000883659
resolver
enst
ENST00000883660
resolver
genesymbol
NMI
resolver
hgnc
HGNC:7854
resolver
uniprot
B5BU69
resolver
uniprot
Q53TI8
resolver
uniprot
Q8WTW2
resolver
uniprot
Q9BVE5
resolver
uniprot_entry
NMI_HUMAN
resolver
uniprot_sec
B5BU69
resolver
uniprot_sec
Q53TI8
resolver
uniprot_sec
Q8WTW2
resolver
uniprot_sec
Q9BVE5
resolver
amino_acid_sequence
MEADKDDTQQILKEHSPDEFIKDEQNKGLIDEITKKNIQLKKEIQKLETELQEATKEFQIKEDIPETKMKFLSVETPENDSQLSNISCSFQVSSKVPYEIQKGQALITFEKEEVAQNVVSMSKHHVQIKDVNLEVTAKPVPLNSGVRFQVYVEVSKMKINVTEIPDTLREDQMRDKLELSFSKSRNGGGEVDRVDYDRQSGSAVITFVEIGVADKILKKKEYPLYINQTCHRVTVSPYTEIHLKKYQIFSGTSKRTVLLTGMEGIQMDEEIVEDLINIHFQRAKNGGGEVDVVKCSLGQPHIAYFEE
uniprot
proteins
function
FUNCTION: Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881, PubMed:9989503). In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis (PubMed:29377960, PubMed:9989503). Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription (PubMed:9989503). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 (PubMed:10779520, PubMed:10950963). In complex with IFI35, inhibits virus-triggered type I IFN-beta production when ubiquitinated by ubiquitin-protein ligase TRIM21 (PubMed:26342464). In complex with IFI35, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Negatively regulates virus-triggered type I interferon/IFN production by inducing proteosome-dependent degradation of IRF7, a transcriptional regulator of type I IFN, thereby interfering with cellular antiviral responses (By similarity). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation, when actively released by macrophage to the extracellular space during cell injury or pathogen invasion (PubMed:29038465). Macrophage-secreted NMI activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 binding and activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465). {ECO:0000250|UniProtKB:O35309, ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:29350881, ECO:0000269|PubMed:9989503}.
uniprot
proteins
mass_dalton
35057
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="K->R: Loss of TRIM21-mediated ubiquitination and loss of Sendai virus-triggered type IIFN-beta production. Loss of TRIM21-mediated ubiquitination and decreased Sendai virus-triggered type IIFN-beta production; when associated with R-27."; /evidence="ECO:0000269|PubMed:26342464"; MUTAGEN 27; /note="K->R: No change in TRIM21-mediated ubiquitination and no change in Sendai virus-triggered type IIFN-beta production. Loss of TRIM21-mediated ubiquitination and decreased Sendai virus-triggered type IIFN-beta production; when associated with R-22."; /evidence="ECO:0000269|PubMed:26342464"; MUTAGEN 56; /note="K->R: No change in TRIM21-mediated ubiquitination; when associated with R-61."; /evidence="ECO:0000269|PubMed:26342464"; MUTAGEN 61; /note="K->R: No change in TRIM21-mediated ubiquitination; when associated with R-56."; /evidence="ECO:0000269|PubMed:26342464"; MUTAGEN 176; /note="K->R: No change in TRIM21-mediated ubiquitination; when associated with R-183."; /evidence="ECO:0000269|PubMed:26342464"; MUTAGEN 183; /note="K->R: No change in TRIM21-mediated ubiquitination; when associated with R-176."; /evidence="ECO:0000269|PubMed:26342464
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. 'Lys-63'-linked ubiquitination by TRIM21 promotes interaction with IFI35 and inhibits virus-triggered type I IFN-beta production. {ECO:0000269|PubMed:26342464}.
uniprot
proteins
protein_family
NMI family
uniprot
proteins
pubmed
10779520
uniprot
proteins
pubmed
10950963
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26342464
uniprot
proteins
pubmed
29038465
uniprot
proteins
pubmed
29350881
uniprot
proteins
pubmed
29377960
uniprot
proteins
pubmed
8668343
uniprot
proteins
pubmed
9781816
uniprot
proteins
pubmed
9989503
uniprot
proteins
sequence_length
307
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:29377960, ECO:0000269|PubMed:9781816}. Nucleus {ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:9781816}. Secreted {ECO:0000269|PubMed:29038465}. Note=Cytoplasmic NMI localizes in punctate granular structures (PubMed:10950963, PubMed:9781816). Nuclear localization increased following IFN-alpha treatment (PubMed:10950963, PubMed:9781816). Extracellular following secretion by macrophage (PubMed:29038465). {ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:9781816}.
uniprot
proteins