Ntrk2
entrez
18212
canonical
uniprot
P15209
canonical
ensembl
ENSMUSG00000055254
resolver
ensp
ENSMUSP00000078757
resolver
ensp
ENSMUSP00000153270
resolver
ensp
ENSMUSP00000153333
resolver
ensp
ENSMUSP00000153553
resolver
ensp
ENSMUSP00000283950
resolver
ensp
ENSMUSP00000283958
resolver
ensp
ENSMUSP00000283959
resolver
ensp
ENSMUSP00000283961
resolver
ensp
ENSMUSP00000283963
resolver
ensp
ENSMUSP00000283966
resolver
ensp
ENSMUSP00000283977
resolver
enst
ENSMUST00000224402
resolver
genesymbol
Ntrk2
resolver
genesymbol_syn
Trkb
resolver
uniprot
A0A286YDA3
resolver
uniprot
Q3TUF9
resolver
uniprot
Q3UHE3
resolver
uniprot
Q80WU0
resolver
uniprot
Q91XJ9
resolver
uniprot_entry
A0A286YDA3_MOUSE
resolver
uniprot_entry
NTRK2_MOUSE
resolver
uniprot_entry
Q3UHE3_MOUSE
resolver
uniprot_sec
Q3TUF9
resolver
uniprot_sec
Q80WU0
resolver
uniprot_sec
Q91XJ9
resolver
activity_regulation
ACTIVITY REGULATION: The formation of active receptors dimers able to fully transduce the ligand-mediated signal, may be negatively regulated by the formation of inactive heterodimers with the non-catalytic isoforms (By similarity). The neuronal activity and the influx of calcium positively regulate the kinase activity and the internalization of the receptor which are both important for active signaling. Regulated by NGFR that may control the internalization of the receptor. NGFR may also stimulate the activation by BDNF compared to NTF3 and NTF4. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. {ECO:0000250|UniProtKB:Q63604, ECO:0000269|PubMed:14581459, ECO:0000269|PubMed:16113645, ECO:0000269|PubMed:16223723}.
uniprot
proteins
amino_acid_sequence
MSPWLKWHGPAMARLWGLCLLVLGFWRASLACPTSCKCSSARIWCTEPSPGIVAFPRLEPNSVDPENITEILIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAYKAFLKNSNLRHINFTRNKLTSLSRRHFRHLDLSDLILTGNPFTCSCDIMWLKTLQETKSSPDTQDLYCLNESSKNMPLANLQIPNCGLPSARLAAPNLTVEEGKSVTLSCSVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNYPEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQSNREHLSVYAVVVIASVVGFCLLVMLLLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKSIHTLLQNLAKASPVYLDILG
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. Isoform GP95-TRKB may also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. {ECO:0000269|PubMed:10571233, ECO:0000269|PubMed:12367511, ECO:0000269|PubMed:15329723, ECO:0000269|PubMed:15372074, ECO:0000269|PubMed:1645620, ECO:0000269|PubMed:16801538, ECO:0000269|PubMed:21414899, ECO:0000269|PubMed:27457814, ECO:0000269|PubMed:8402890, ECO:0000269|PubMed:9728914}.
uniprot
proteins
mass_dalton
92133
uniprot
proteins
mutagenesis
MUTAGEN 515; /note="Y->F: Loss of interaction with SHC1."; /evidence="ECO:0000269|PubMed:12367511"; MUTAGEN 816; /note="Y->F: Loss of interaction with PLCG1."; /evidence="ECO:0000269|PubMed:12367511
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors (PubMed:27457814). Some isoforms are not phosphorylated (By similarity). {ECO:0000250, ECO:0000269|PubMed:27457814}.; PTM: Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor. {ECO:0000269|PubMed:16113645}.
uniprot
proteins
protein_family
Insulin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10571233
uniprot
proteins
pubmed
12367511
uniprot
proteins
pubmed
14581459
uniprot
proteins
pubmed
14603320
uniprot
proteins
pubmed
15329723
uniprot
proteins
pubmed
15372074
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16113645
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16223723
uniprot
proteins
pubmed
1645620
uniprot
proteins
pubmed
16801538
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21414899
uniprot
proteins
pubmed
2160854
uniprot
proteins
pubmed
21849472
uniprot
proteins
pubmed
23785138
uniprot
proteins
pubmed
23977241
uniprot
proteins
pubmed
2555172
uniprot
proteins
pubmed
27457814
uniprot
proteins
pubmed
8402890
uniprot
proteins
pubmed
9148911
uniprot
proteins
pubmed
9728914
uniprot
proteins
sequence_length
821
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14581459}; Single-pass type I membrane protein {ECO:0000269|PubMed:14581459}. Endosome membrane {ECO:0000269|PubMed:14581459}; Single-pass type I membrane protein {ECO:0000269|PubMed:14581459}. Early endosome membrane {ECO:0000269|PubMed:21849472}. Cell projection, axon {ECO:0000250|UniProtKB:Q63604}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63604}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q63604}. Postsynaptic density {ECO:0000269|PubMed:27457814}. Note=Internalized to endosomes upon ligand-binding. {ECO:0000269|PubMed:21849472}.
uniprot
proteins
transmembrane_region
TRANSMEM 430..453; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins