Fcn2
entrez
14134
canonical
uniprot
O70497
canonical
ensembl
ENSMUSG00000026835
resolver
ensp
ENSMUSP00000028179
resolver
enst
ENSMUST00000028179
resolver
genesymbol
Fcn2
resolver
genesymbol_syn
Fcnb
resolver
uniprot
Q3KNL6
resolver
uniprot_entry
FCN2_MOUSE
resolver
uniprot_sec
Q3KNL6
resolver
amino_acid_sequence
MALGSAALFVLTLTVHAAGTCPELKVLDLEGYKQLTILQGCPGLPGAAGPKGEAGAKGDRGESGLPGIPGKEGPTGPKGNQGEKGIRGEKGDSGPSQSCATGPRTCKELLTQGHFLTGWYTIYLPDCRPLTVLCDMDTDGGGWTVFQRRLDGSVDFFRDWTSYKRGFGSQLGEFWLGNDNIHALTTQGTSELRVDLSDFEGKHDFAKYSSFQIQGEAEKYKLILGNFLGGGAGDSLTPHNNRLFSTKDQDNDGSTSSCAMGYHGAWWYSQCHTSNLNGLYLRGPHKSYANGVNWKSWRGYNYSCKVSEMKVRLI
uniprot
proteins
function
FUNCTION: Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Specifically binds N-Acetylglucosamine (GlcNAc), as well as phosphocholine and lipoteichoic acid moieties on the surface of pathogens. {ECO:0000250|UniProtKB:Q15485}.
uniprot
proteins
mass_dalton
33984
uniprot
proteins
protein_family
Ficolin lectin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9851834
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q15485}. Cell surface {ECO:0000250|UniProtKB:Q15485}. Note=Specifically binds carbohydrates on the surface of pathogens. {ECO:0000250|UniProtKB:Q15485}.
uniprot
proteins