Dctn2
entrez
299850
canonical
uniprot
Q6AYH5
canonical
ensembl
ENSRNOG00000025481
resolver
ensp
ENSRNOP00000008120
resolver
ensp
ENSRNOP00000099441
resolver
enst
ENSRNOT00000152569
resolver
genesymbol
Dctn2
resolver
uniprot
A0ABK0L5M5
resolver
uniprot_entry
A0ABK0L5M5_RAT
resolver
uniprot_entry
DCTN2_RAT
resolver
amino_acid_sequence
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELSSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGDYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLADPDGALAKRLLLQLEATKSSKGSSGGKSTGGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGACLMETVELLQAKVNALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQNKVHQLYETIQRWSPVASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMMASSLKDNTALLTQVQTTMRENLATVEGNFASIDARMKKLGK
uniprot
proteins
function
FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}.
uniprot
proteins
mass_dalton
44148
uniprot
proteins
protein_family
Dynactin subunit 2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
402
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q13561}. Membrane {ECO:0000250|UniProtKB:Q13561}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q13561}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0A5G2QD80}.
uniprot
proteins