CDKN3
entrez
1033
canonical
uniprot
Q16667
canonical
ensembl
ENSG00000100526
resolver
ensp
ENSP00000335357
resolver
ensp
ENSP00000415333
resolver
ensp
ENSP00000450711
resolver
enst
ENST00000556102
resolver
genesymbol
CDKN3
resolver
genesymbol_syn
CDI1
resolver
genesymbol_syn
CIP2
resolver
genesymbol_syn
KAP
resolver
hgnc
HGNC:1791
resolver
uniprot
G3V2J7
resolver
uniprot
Q53ZU6
resolver
uniprot
Q5U0M4
resolver
uniprot
Q6P1N8
resolver
uniprot
Q99585
resolver
uniprot
Q9BPW7
resolver
uniprot
Q9BY36
resolver
uniprot
Q9C042
resolver
uniprot
Q9C046
resolver
uniprot
Q9C047
resolver
uniprot
Q9C049
resolver
uniprot
Q9C051
resolver
uniprot
Q9C053
resolver
uniprot_entry
CDKN3_HUMAN
resolver
uniprot_entry
G3V2J7_HUMAN
resolver
uniprot_sec
Q53ZU6
resolver
uniprot_sec
Q5U0M4
resolver
uniprot_sec
Q6P1N8
resolver
uniprot_sec
Q99585
resolver
uniprot_sec
Q9BPW7
resolver
uniprot_sec
Q9BY36
resolver
uniprot_sec
Q9C042
resolver
uniprot_sec
Q9C046
resolver
uniprot_sec
Q9C047
resolver
uniprot_sec
Q9C049
resolver
uniprot_sec
Q9C051
resolver
uniprot_sec
Q9C053
resolver
amino_acid_sequence
MKPPSSIQTSEFDSSDEEPIEDEQTPIHISWLSLSRVNCSQFLGLCALPGCKFKDVRRNVQKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCGIITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYLSDTISPEQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKLAAHLSSRDSQSRSVSR
uniprot
proteins
disease_involvement
DISEASE: Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. {ECO:0000269|PubMed:10987270}. Note=The gene represented in this entry may be involved in disease pathogenesis.
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: May play a role in cell cycle regulation. Dual specificity CC phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues (PubMed:8127873, PubMed:8242750). Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (PubMed:7569954). {ECO:0000269|PubMed:7569954, ECO:0000269|PubMed:8127873, ECO:0000269|PubMed:8242750}.
uniprot
proteins
mass_dalton
23805
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
10669749
uniprot
proteins
pubmed
10987270
uniprot
proteins
pubmed
11463386
uniprot
proteins
pubmed
11781350
uniprot
proteins
pubmed
12745075
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15671017
uniprot
proteins
pubmed
7569954
uniprot
proteins
pubmed
8127873
uniprot
proteins
pubmed
8242750
uniprot
proteins
sequence_length
212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:10669749}.
uniprot
proteins