Ndp
entrez
17986
canonical
uniprot
P48744
canonical
ensembl
ENSMUSG00000040138
resolver
ensp
ENSMUSP00000046692
resolver
enst
ENSMUST00000040134
resolver
genesymbol
Ndp
resolver
genesymbol_syn
Ndph
resolver
uniprot
Q5CZY6
resolver
uniprot_entry
NDP_MOUSE
resolver
uniprot_sec
Q5CZY6
resolver
amino_acid_sequence
MRNHVLAASISMLSLLAIMGDTDSKTDSSFLMDSQRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECSS
uniprot
proteins
function
FUNCTION: Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction. {ECO:0000269|PubMed:15035989, ECO:0000269|PubMed:19837033}.
uniprot
proteins
mass_dalton
14700
uniprot
proteins
pubmed
10452356
uniprot
proteins
pubmed
15035989
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19837033
uniprot
proteins
pubmed
8789439
uniprot
proteins
pubmed
8835523
uniprot
proteins
sequence_length
131
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins