Hgs
entrez
15239
canonical
uniprot
Q99LI8
canonical
ensembl
ENSMUSG00000025793
resolver
ensp
ENSMUSP00000101809
resolver
ensp
ENSMUSP00000101811
resolver
ensp
ENSMUSP00000315533
resolver
ensp
ENSMUSP00000315543
resolver
ensp
ENSMUSP00000315546
resolver
ensp
ENSMUSP00000315551
resolver
enst
ENSMUST00000106203
resolver
enst
ENSMUST00000106205
resolver
genesymbol
Hgs
resolver
genesymbol_syn
Hrs
resolver
uniprot
A0ACM8Q8J0
resolver
uniprot
B1ATZ1
resolver
uniprot
Q3UMA3
resolver
uniprot
Q61691
resolver
uniprot
Q8BQW3
resolver
uniprot_entry
A0ACM8Q8J0_MOUSE
resolver
uniprot_entry
HGS_MOUSE
resolver
uniprot_entry
Q3UMA3_MOUSE
resolver
uniprot_sec
B1ATZ1
resolver
uniprot_sec
Q61691
resolver
uniprot_sec
Q8BQW3
resolver
amino_acid_sequence
MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKELLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNKKAEGKASSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERMRQKTTYTAHPKAEPTPLASSAPPAGSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQPGEGHTAPNSMAEAPLPETDSQPITPCSGPFSEYQNGESEESHEQFLKALQNAVSTFVNRMKSNHMRGRSITNDSAVLSLFQSINTMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPTAGGVLYQPSGPTSFPATFSPAGSVEGSPMHGVYMSQPAPATGPYPSMPGTTADPSMVSAYMYPTGAPGAQAAPQAQAGPTTSPAYSSYQPTPTPGYQSVASQAPQSLPAISQPPQTSNIGYMGSQPMSMGYQPYNMQNLMTALPGQDASLPAQQPYIPGQQPLYQQMAPSTGPPQQQPPVAQPAPTQGPPAQGSEAQLISFD
uniprot
proteins
function
FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. {ECO:0000269|PubMed:11094085}.
uniprot
proteins
mass_dalton
86015
uniprot
proteins
mutagenesis
MUTAGEN 183; /note="R->A: 100-fold loss of affinity for PIP3 and accumulation in the cytosol."; /evidence="ECO:0000269|PubMed:11493665"; MUTAGEN 215; /note="C->S: Accumulation in proteinaceous aggregates devoid of membranes and no interaction with PI3P."; /evidence="ECO:0000269|PubMed:11493665"; MUTAGEN 269; /note="L->A: Loss of protein phosphorylation at Y-329 and Y-334; when associated with A-270."; /evidence="ECO:0000269|PubMed:12953068"; MUTAGEN 270; /note="S->A: Loss of protein phosphorylation at Y-329 and Y-334; when associated with A-269."; /evidence="ECO:0000269|PubMed:11988743, ECO:0000269|PubMed:12953068"; MUTAGEN 270; /note="S->E: No interaction with ubiquitin."; /evidence="ECO:0000269|PubMed:11988743, ECO:0000269|PubMed:12953068"; MUTAGEN 329; /note="Y->F: No change in the phosphorylation level. Loss of protein phosphorylation; when associated with F-334."; /evidence="ECO:0000269|PubMed:12953068"; MUTAGEN 334; /note="Y->F: No change in the phosphorylation level. Loss of protein phosphorylation; when associated with F-329."; /evidence="ECO:0000269|PubMed:12953068
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr-334. This phosphorylation occurs in response to EGF. A minor site of phosphorylation on Tyr-329 is detected. Protein phosphorylation may also be triggered in response to IL-2, GM-CSF and HGF. {ECO:0000269|PubMed:12953068}.; PTM: Ubiquitinated by ITCH. {ECO:0000250|UniProtKB:O14964}.
uniprot
proteins
pubmed
10364163
uniprot
proteins
pubmed
10651905
uniprot
proteins
pubmed
11094085
uniprot
proteins
pubmed
11493665
uniprot
proteins
pubmed
11988743
uniprot
proteins
pubmed
12802020
uniprot
proteins
pubmed
12953068
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16159959
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19278655
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7565774
uniprot
proteins
pubmed
9407053
uniprot
proteins
pubmed
9630564
uniprot
proteins
sequence_length
775
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome, multivesicular body membrane; Peripheral membrane protein. Note=Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments. {ECO:0000250|UniProtKB:O14964}.
uniprot
proteins