Cdk5rap1
entrez
252827
canonical
uniprot
Q9JLH6
canonical
ensembl
ENSRNOG00000015696
resolver
ensembl
ENSRNOG00055026288
resolver
ensembl
ENSRNOG00060024939
resolver
ensembl
ENSRNOG00065025137
resolver
ensp
ENSRNOP00000105568
resolver
ensp
ENSRNOP00000110028
resolver
ensp
ENSRNOP00055037162
resolver
ensp
ENSRNOP00060035713
resolver
ensp
ENSRNOP00065035461
resolver
enst
ENSRNOT00000140954
resolver
enst
ENSRNOT00055045343
resolver
enst
ENSRNOT00060043153
resolver
enst
ENSRNOT00065043265
resolver
genesymbol
Cdk5rap1
resolver
uniprot
A0ABK0LP80
resolver
uniprot_entry
A0ABK0LP80_RAT
resolver
uniprot_entry
CK5P1_RAT
resolver
amino_acid_sequence
MHPLQRVFRAQRLSAPLTSMCWVLLRTFRAHNSTSCPDPEGKSSEGVQKDFSSRLATGPTFQHFLRSASVPQEKPSSPEVEDPPPYLSGDELLGRQRKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKVLKAKRPRSRVPLRIGILGCMAERLKGEILNREKMVDLLAGPDAYRDLPRLLAVVESGQQAANVLLSLDETYADIMPVQTSPSATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPVASILDEVRKLSEQGLKEVTLLGQNVNSFRDNSEVQFSSTGSANLSRGFTTNYKPKQGGLRFSHLLDQVSRIDPEMRIRFTSPHPKDFPDEVLQLIRERHNICKQIHLPAQSGSSRVLEAMRRGYSREAYVALVHHIREAIPGVGLSSDFITGFCGETEDDHLQTVSLLREVQYNTGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITVFREEASKVNATSVGCTQLVLVEGFSKRSTTDLCGRNDANLKVIFPDAEVEDITDPGLKVRAQPGDYVLVKIISASSQTLKGHILCRTTMKDSSMNCLT
uniprot
proteins
ec_number
2.8.4.3
uniprot
proteins
function
FUNCTION: Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (By similarity). Essential for efficient and highly accurate protein translation by the ribosome (By similarity). Specifically inhibits CDK5 activation by CDK5R1 (By similarity). Essential for efficient mitochondrial protein synthesis and respiratory chain (By similarity). {ECO:0000250|UniProtKB:Q96SZ6}.
uniprot
proteins
mass_dalton
65866
uniprot
proteins
protein_family
Methylthiotransferase family
uniprot
proteins
protein_family
MiaB subfamily
uniprot
proteins
pubmed
10721722
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
586
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q96SZ6}.
uniprot
proteins