Nme2
entrez
83782
canonical
uniprot
P19804
canonical
ensembl
ENSRNOG00000002671
resolver
ensembl
ENSRNOG00055032669
resolver
ensembl
ENSRNOG00060030273
resolver
ensembl
ENSRNOG00065018324
resolver
ensp
ENSRNOP00000003611
resolver
ensp
ENSRNOP00055046559
resolver
ensp
ENSRNOP00060043726
resolver
ensp
ENSRNOP00065024435
resolver
enst
ENSRNOT00000003611
resolver
enst
ENSRNOT00055056453
resolver
enst
ENSRNOT00060052572
resolver
enst
ENSRNOT00065030712
resolver
genesymbol
Nme2
resolver
uniprot_entry
NDKB_RAT
resolver
amino_acid_sequence
MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFKPEELIDYKSCAHDWVYE
uniprot
proteins
ec_number
2.7.13.3
uniprot
proteins
ec_number
2.7.4.6
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis (PubMed:2832402). Also functions as a histidine protein kinase by transferring the phosphoryl group from the phosphohistidine intermediate to a histidine residue in target proteins (By similarity). Phosphorylates the GNB1 subunit of heterotrimeric G proteins at 'His-266', generating a high-energy phosphate group that promotes GTP formation and enables receptor-independent activation of heterotrimeric G proteins (By similarity). Also phosphorylates KCNN4 at 'His-358', leading to activation of its intermediate conductance calcium-activated potassium channel activity, Ca(2+) influx, and subsequent activation of B and T cells. Additionally involved in transcriptional regulation through direct DNA binding and chromatin remodeling. In this context, functions as a single-stranded DNA binding protein that binds and stabilizes the G-quadruplex (G4) structures within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter, facilitating recruitment of additional single-strand DNA binding proteins and activation of MYC transcription. G4 DNA-binding activity is independent of its nucleoside diphosphate kinase function and recognizes both folded and unfolded G4 structures (By similarity). With NME1, may regulate acetyl-CoA (AcCoA) usage between histone acetylation and fatty acid synthesis by targeting AcCoA release at ATP-rich, HAT-associated chromatin regions (By similarity). Also negatively regulates Rho activity by interacting with AKAP13/LBC (By similarity). {ECO:0000250|UniProtKB:P22392, ECO:0000250|UniProtKB:Q01768, ECO:0000250|UniProtKB:Q3T0Q4, ECO:0000269|PubMed:2832402}.
uniprot
proteins
mass_dalton
17283
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000250|UniProtKB:P22392}.
uniprot
proteins
protein_family
NDK family
uniprot
proteins
pubmed
1316151
uniprot
proteins
pubmed
1321145
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17532299
uniprot
proteins
pubmed
2168422
uniprot
proteins
pubmed
2832402
uniprot
proteins
sequence_length
152
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P22392}. Nucleus {ECO:0000250|UniProtKB:P22392}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P22392}. Cell projection, ruffle {ECO:0000250|UniProtKB:P22392}. Note=Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates. {ECO:0000250|UniProtKB:P22392}.
uniprot
proteins