PRSS8
entrez
5652
canonical
uniprot
Q16651
canonical
ensembl
ENSG00000052344
resolver
ensp
ENSP00000319730
resolver
genesymbol
PRSS8
resolver
hgnc
HGNC:9491
resolver
uniprot
B4DWP2
resolver
uniprot
Q9UCA3
resolver
uniprot_entry
PRSS8_HUMAN
resolver
uniprot_sec
B4DWP2
resolver
uniprot_sec
Q9UCA3
resolver
amino_acid_sequence
MAQKGVLGPGQLGAVAILLYLGLLRSGTGAEGAEAPCGVAPQARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRVVPQTQESQPDSNLCGSHLAFSSAPAQGLLRPILFLPLGLALGLLSPWLSEH
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). {ECO:0000269|PubMed:15246975, ECO:0000269|PubMed:15474520}.
uniprot
proteins
mass_dalton
36431
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15246975
uniprot
proteins
pubmed
15474520
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
19388054
uniprot
proteins
pubmed
7768952
uniprot
proteins
pubmed
8034638
uniprot
proteins
sequence_length
343
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Prostasin]: Cell membrane; Single-pass membrane protein.; SUBCELLULAR LOCATION: [Prostasin light chain]: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus.; SUBCELLULAR LOCATION: [Prostasin heavy chain]: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus.
uniprot
proteins
transmembrane_region
TRANSMEM 320..340; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins