Stra8
entrez
20899
canonical
uniprot
P70278
canonical
ensembl
ENSMUSG00000029848
resolver
ensp
ENSMUSP00000031876
resolver
ensp
ENSMUSP00000110649
resolver
ensp
ENSMUSP00000110651
resolver
enst
ENSMUST00000031876
resolver
enst
ENSMUST00000114997
resolver
enst
ENSMUST00000114999
resolver
genesymbol
Stra8
resolver
uniprot
F2Z435
resolver
uniprot
Q496Q5
resolver
uniprot_entry
F2Z435_MOUSE
resolver
uniprot_entry
STRA8_MOUSE
resolver
uniprot_sec
Q496Q5
resolver
amino_acid_sequence
MATPGEGNQPSDDGAPQPLAQLQKLEPRVVRRRLSQARHRATLVGLFNNLRKAVYSQSDITASKWQVLNRTKIHIQEQEESLDKLLKLKASFNLQDGNPNSLEEVKEEYARMYSENDSVFLNSFLQDSPPEWFPSEAVGPDAEEEGEEEGEEEGEEGEEEEEGDEEGEEEEENGEEREVEEYQEEEEEEEEEEKKVDLSHSSSTLLPDLMEFERYLNFYKQTMDLLTMNSIISAHEVTLPIVSAAISHLWQTLSEEKKARLLQVWEQQHSAFADLTEACLELAGVEGSMKDSGVDSQGASCSLESTPEEILFEDAFDVASFLDKSEAQHMSNISAMFATCNSENPEEKFQLYIQIIEFFKSLGCVNTPLNQEPEPPDDDDAMLLKCLETFDDL
uniprot
proteins
function
FUNCTION: Meiosis-inducer required for the transition into meiosis for both female and male germ cells (PubMed:16461896, PubMed:17115059, PubMed:18799751, PubMed:18799790, PubMed:19805549, PubMed:32032549, PubMed:32054698). In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase (PubMed:16461896, PubMed:17115059, PubMed:18799751, PubMed:18799790, PubMed:32054698). During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation (PubMed:25902548). In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis (PubMed:19805549, PubMed:32032549). {ECO:0000269|PubMed:16461896, ECO:0000269|PubMed:17115059, ECO:0000269|PubMed:18799751, ECO:0000269|PubMed:18799790, ECO:0000269|PubMed:19805549, ECO:0000269|PubMed:25902548, ECO:0000269|PubMed:32032549, ECO:0000269|PubMed:32054698}.
uniprot
proteins
mass_dalton
44555
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in P19 EC cells. {ECO:0000269|PubMed:8896602}.
uniprot
proteins
pubmed
14550793
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16461896
uniprot
proteins
pubmed
17115059
uniprot
proteins
pubmed
18322276
uniprot
proteins
pubmed
18799751
uniprot
proteins
pubmed
18799790
uniprot
proteins
pubmed
19805549
uniprot
proteins
pubmed
20951351
uniprot
proteins
pubmed
25902548
uniprot
proteins
pubmed
32032549
uniprot
proteins
pubmed
32054698
uniprot
proteins
pubmed
8896602
uniprot
proteins
sequence_length
393
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19805549, ECO:0000269|PubMed:32032549, ECO:0000269|PubMed:8896602}. Nucleus {ECO:0000269|PubMed:19805549, ECO:0000269|PubMed:32032549}. Note=Shuttles between nucleus and cytoplasm (PubMed:19805549). Nuclear export is XPO1-dependent (PubMed:19805549). {ECO:0000269|PubMed:19805549}.
uniprot
proteins