RAB30
entrez
27314
canonical
uniprot
Q15771
canonical
ensembl
ENSG00000137502
resolver
ensp
ENSP00000260056
resolver
ensp
ENSP00000435089
resolver
ensp
ENSP00000435189
resolver
ensp
ENSP00000478702
resolver
genesymbol
RAB30
resolver
hgnc
HGNC:9770
resolver
uniprot
A8K5R1
resolver
uniprot
Q6FGK1
resolver
uniprot
Q6MZH2
resolver
uniprot
Q96CI8
resolver
uniprot_entry
A8K5R1_HUMAN
resolver
uniprot_entry
RAB30_HUMAN
resolver
uniprot_sec
Q6FGK1
resolver
uniprot_sec
Q6MZH2
resolver
uniprot_sec
Q96CI8
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) including USP6NL, which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MSMEDYDFLFKIVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEINGEKVKLQIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYASNKVITVLVGNKIDLAERREVSQQRAEEFSEAQDMYYLETSAKESDNVEKLFLDLACRLISEARQNTLVNNVSSPLPGEGKSISYLTCCNFN
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:22188167). RAB30 is required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins (PubMed:22188167). Facilitates lipid homeostasis during fasting by regulating hepatic protein and lipid trafficking in a PPAR-alpha-dependent manner (By similarity). Promotes autophagosome biogenesis during bacterial infection such as group A Streptococcus infection (PubMed:26771875). {ECO:0000250|UniProtKB:Q923S9, ECO:0000269|PubMed:22188167, ECO:0000269|PubMed:26771875}.
uniprot
proteins
mass_dalton
23058
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="T->N: Constitutively inactive (GDP-bound) mutant. Decreased colocalization with group AStreptococcus-containing autophagosome-like vacuoles."; /evidence="ECO:0000269|PubMed:26771875"; MUTAGEN 68; /note="Q->L: Constitutively active (GTP-bound) mutant. Increased colocalization with group AStreptococcus-containing autophagosome-like vacuoles."; /evidence="ECO:0000269|PubMed:26771875
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16086013
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22188167
uniprot
proteins
pubmed
26771875
uniprot
proteins
pubmed
8863739
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:22188167}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:26771875}. Golgi apparatus membrane {ECO:0000269|PubMed:22188167}. Cytoplasm {ECO:0000269|PubMed:22188167}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:26771875}. Autolysosome membrane {ECO:0000269|PubMed:26771875}. Note=Localized to dynamic membranes fusing to and exiting from the Golgi apparatus (By similarity). Localized to group A Streptococcus (GAS)-containing autophagosome to autolysosome in GAS-infected epithelial cells (PubMed:26771875). Also colocalized with a starvation-induced autophagosome although not required for autophagosome formation during starvation (PubMed:26771875). {ECO:0000250|UniProtKB:Q923S9, ECO:0000269|PubMed:26771875}.
uniprot
proteins