Mtfr1l
entrez
76824
canonical
uniprot
Q9CWE0
canonical
ensembl
ENSMUSG00000046671
resolver
ensp
ENSMUSP00000099609
resolver
ensp
ENSMUSP00000111983
resolver
ensp
ENSMUSP00000175392
resolver
ensp
ENSMUSP00000175414
resolver
ensp
ENSMUSP00000175429
resolver
ensp
ENSMUSP00000175433
resolver
genesymbol
Mtfr1l
resolver
genesymbol_syn
Fam54b
resolver
uniprot
Q3UJK3
resolver
uniprot
Q8BTP7
resolver
uniprot_entry
MFR1L_MOUSE
resolver
uniprot_sec
Q3UJK3
resolver
uniprot_sec
Q8BTP7
resolver
amino_acid_sequence
MEANVTIPIWQNKPHGAARSVVRRIGTNLPLKPCPRASFETLPNISDLCLKDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVPNLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFFSSGSSNVSSPLPCFGSSLHSTTSFVISDITEETEVEVPELPTVPLLCSASPECCKPEHKTTCSSSEEDDCISLSKASSFADMMGILKDFHRIKQSQDLSRSLLKEEDPAVLISEVLRRKFALKEEDISRKGN
uniprot
proteins
function
FUNCTION: Mitochondrial protein required for adaptation of mitochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels. {ECO:0000269|PubMed:36367943}.
uniprot
proteins
mass_dalton
31726
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by AMPK. Upon stress, phosphorylation at Ser-100 and Ser-235 by AMPK is sufficient to induce mitochondrial fragmentation. {ECO:0000250|UniProtKB:Q9H019}.
uniprot
proteins
protein_family
MTFR1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36367943
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:36367943}; Peripheral membrane protein {ECO:0000269|PubMed:36367943}; Cytoplasmic side {ECO:0000269|PubMed:36367943}.
uniprot
proteins