NGDN
entrez
25983
canonical
uniprot
Q8NEJ9
canonical
ensembl
ENSG00000129460
resolver
ensp
ENSP00000380340
resolver
ensp
ENSP00000386134
resolver
genesymbol
NGDN
resolver
genesymbol_syn
C14orf120
resolver
hgnc
HGNC:20271
resolver
uniprot
A8K760
resolver
uniprot
Q9Y400
resolver
uniprot_entry
NGDN_HUMAN
resolver
uniprot_sec
A8K760
resolver
uniprot_sec
Q9Y400
resolver
amino_acid_sequence
MAALGVLESDLPSAVTLLKNLQEQVMAVTAQVKSLTQKVQAGAYPTEKGLSFLEVKDQLLLMYLMDLTHLILDKASGGSLQGHDAVLRLVEIRTVLEKLRPLDQKLKYQIDKLIKTAVTGSLSENDPLRFKPHPSNMMSKLSSEDEEEDEAEDDQSEASGKKSVKGVSKKYVPPRLVPVHYDETEAEREKKRLERAKRRALSSSVIRELKEQYSDAPEEIRDARHPHVTRQSQEDQHRINYEESMMVRLSVSKREKGRRKRANVMSSQLHSLTHFSDISALTGGTVHLDEDQNPIKKRKKIPQKGRKKKGFRRRR
uniprot
proteins
function
FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (PubMed:34516797). Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q9DB96, ECO:0000269|PubMed:34516797}.
uniprot
proteins
mass_dalton
35894
uniprot
proteins
protein_family
SAS10 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18547334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
34516797
uniprot
proteins
sequence_length
315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9DB96}. Nucleus, nucleolus {ECO:0000269|PubMed:18547334, ECO:0000269|PubMed:34516797}. Chromosome, centromere {ECO:0000269|PubMed:18547334}. Cytoplasm {ECO:0000250|UniProtKB:Q9DB96}. Cell projection, axon {ECO:0000250|UniProtKB:Q9DB96}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9DB96}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9DB96}. Note=Translocated from nucleolus to nuclear foci in response to UV damage (By similarity). Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites. {ECO:0000250|UniProtKB:Q9DB96}.
uniprot
proteins