PPP2CB
entrez
5516
canonical
uniprot
P62714
canonical
ensembl
ENSG00000104695
resolver
ensp
ENSP00000221138
resolver
ensp
ENSP00000576129
resolver
enst
ENST00000221138
resolver
enst
ENST00000906070
resolver
genesymbol
PPP2CB
resolver
hgnc
HGNC:9300
resolver
uniprot
A0A140VJS0
resolver
uniprot
D3DSV4
resolver
uniprot
P11082
resolver
uniprot
Q6FHK5
resolver
uniprot_entry
A0A140VJS0_HUMAN
resolver
uniprot_entry
PP2AB_HUMAN
resolver
uniprot_sec
D3DSV4
resolver
uniprot_sec
P11082
resolver
uniprot_sec
Q6FHK5
resolver
amino_acid_sequence
MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:2555176, ECO:0000305}.
uniprot
proteins
mass_dalton
35575
uniprot
proteins
mutagenesis
MUTAGEN 59; /note="H->Q: Catalytically inactive. No effect on interaction with PPME1."; /evidence="ECO:0000269|PubMed:10318862"; MUTAGEN 118; /note="H->Q: Catalytically inactive. No effect on interaction with PPME1."; /evidence="ECO:0000269|PubMed:10318862
uniprot
proteins
post_translational_modification
PTM: Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization. {ECO:0000269|PubMed:8206937}.; PTM: Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.; PTM: May be monoubiquitinated by NOSIP. {ECO:0000250|UniProtKB:P62715}.
uniprot
proteins
protein_family
PP-1 subfamily
uniprot
proteins
protein_family
PPP phosphatase family
uniprot
proteins
pubmed
10318862
uniprot
proteins
pubmed
12952889
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541025
uniprot
proteins
pubmed
1846293
uniprot
proteins
pubmed
18782753
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2153055
uniprot
proteins
pubmed
2555176
uniprot
proteins
pubmed
2837763
uniprot
proteins
pubmed
2849765
uniprot
proteins
pubmed
8206937
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16541025}. Nucleus {ECO:0000269|PubMed:16541025}. Chromosome, centromere {ECO:0000269|PubMed:16541025}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16541025}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.
uniprot
proteins