Gabrr2
entrez
29695
canonical
uniprot
P47742
canonical
ensembl
ENSRNOG00000007490
resolver
ensembl
ENSRNOG00065004872
resolver
ensp
ENSRNOP00000100074
resolver
ensp
ENSRNOP00000110953
resolver
enst
ENSRNOT00000155034
resolver
genesymbol
Gabrr2
resolver
uniprot
A0ABK0LA83
resolver
uniprot_entry
A0ABK0LA83_RAT
resolver
uniprot_entry
GBRR2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: In contrast with rho-1 and rho-3 homopentamers, rho-2 GABAARs are not inhibited by picrotoxin. {ECO:0000269|PubMed:8524843}.
uniprot
proteins
amino_acid_sequence
MPYFMRLALFLFCLMALVESRKPRRKRWTGHLETSKPSHLYKKNLDVTKIRTGKPRPLLRVEDHDFTMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWRDERLAFPSSSNRSMTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDHRAVPARVSLGIMTVLTMSTIITGVNASMPRVSYIRAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQEQKERKLRDKFPCTCGMLHSRTMTLDGSYSESEANSLAGYPRSHILPEEERQDKIVVHLALNSELTSSRKKGLLKGQMGLYIFQNTHAIDKYSRLIFPAFYIVFNLIYWSVFS
uniprot
proteins
function
FUNCTION: Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:8524843). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (By similarity). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:8524843). Rho-2 GABAARs may contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (By similarity). Rho-2 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (By similarity). Rho-2 GABAARs expressed in retina may play a role in retinal neurotransmission (PubMed:7643126). {ECO:0000250|UniProtKB:P24046, ECO:0000250|UniProtKB:P56476, ECO:0000269|PubMed:7643126, ECO:0000269|PubMed:8524843}.
uniprot
proteins
mass_dalton
54296
uniprot
proteins
mutagenesis
MUTAGEN 299; /note="M->T: Loss of picrotoxin resistance."; /evidence="ECO:0000269|PubMed:8524843
uniprot
proteins
protein_family
GABRR2 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
12431995
uniprot
proteins
pubmed
7643126
uniprot
proteins
pubmed
8524843
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P56476}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P56476}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 261..281; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 294..314; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 326..346; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 444..464; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins