ARPC1B
entrez
10095
canonical
uniprot
O15143
canonical
ensembl
ENSG00000130429
resolver
ensp
ENSP00000388802
resolver
ensp
ENSP00000389631
resolver
ensp
ENSP00000398110
resolver
ensp
ENSP00000398620
resolver
ensp
ENSP00000403211
resolver
ensp
ENSP00000410238
resolver
ensp
ENSP00000494033
resolver
ensp
ENSP00000496599
resolver
ensp
ENSP00000567938
resolver
ensp
ENSP00000567939
resolver
ensp
ENSP00000567940
resolver
ensp
ENSP00000567941
resolver
ensp
ENSP00000567942
resolver
ensp
ENSP00000567943
resolver
ensp
ENSP00000567945
resolver
ensp
ENSP00000567946
resolver
ensp
ENSP00000567948
resolver
ensp
ENSP00000567949
resolver
ensp
ENSP00000602890
resolver
ensp
ENSP00000602891
resolver
ensp
ENSP00000640528
resolver
ensp
ENSP00000640529
resolver
ensp
ENSP00000640533
resolver
ensp
ENSP00000640536
resolver
ensp
ENSP00000640537
resolver
ensp
ENSP00000640538
resolver
ensp
ENSP00000640539
resolver
ensp
ENSP00000640540
resolver
enst
ENST00000414376
resolver
enst
ENST00000427217
resolver
enst
ENST00000431816
resolver
enst
ENST00000451682
resolver
enst
ENST00000455009
resolver
enst
ENST00000458033
resolver
enst
ENST00000645391
resolver
enst
ENST00000646101
resolver
enst
ENST00000897879
resolver
enst
ENST00000897880
resolver
enst
ENST00000897881
resolver
enst
ENST00000897882
resolver
enst
ENST00000897883
resolver
enst
ENST00000897884
resolver
enst
ENST00000897886
resolver
enst
ENST00000897887
resolver
enst
ENST00000897889
resolver
enst
ENST00000897890
resolver
enst
ENST00000932831
resolver
enst
ENST00000932832
resolver
enst
ENST00000970469
resolver
enst
ENST00000970470
resolver
enst
ENST00000970474
resolver
enst
ENST00000970477
resolver
enst
ENST00000970478
resolver
enst
ENST00000970479
resolver
enst
ENST00000970480
resolver
enst
ENST00000970481
resolver
genesymbol
ARPC1B
resolver
genesymbol_syn
ARC41
resolver
hgnc
HGNC:704
resolver
uniprot
A4D275
resolver
uniprot
Q9BU00
resolver
uniprot_entry
A4D275_HUMAN
resolver
uniprot_entry
ARC1B_HUMAN
resolver
uniprot_sec
Q9BU00
resolver
amino_acid_sequence
MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFITDNSLVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGGTAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDLKIK
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia (IMD71) [MIM:617718]: An autosomal recessive disorder characterized by platelet abnormalities, vasculitis, eosinophilia, and predisposition to inflammatory diseases. {ECO:0000269|PubMed:28368018}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:11741539, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.
uniprot
proteins
mass_dalton
40950
uniprot
proteins
protein_family
WD repeat ARPC1 family
uniprot
proteins
pubmed
11741539
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
28368018
uniprot
proteins
pubmed
29925947
uniprot
proteins
pubmed
9230079
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11741539, ECO:0000269|PubMed:9230079}. Nucleus {ECO:0000269|PubMed:29925947}.
uniprot
proteins