MAP3K13
entrez
9175
canonical
uniprot
O43283
canonical
ensembl
ENSG00000073803
resolver
ensp
ENSP00000265026
resolver
ensp
ENSP00000399910
resolver
ensp
ENSP00000409325
resolver
ensp
ENSP00000411483
resolver
ensp
ENSP00000571905
resolver
ensp
ENSP00000571907
resolver
genesymbol
MAP3K13
resolver
genesymbol_syn
LZK
resolver
hgnc
HGNC:6852
resolver
uniprot
B2R6U2
resolver
uniprot
B4DLE3
resolver
uniprot
B4DMV2
resolver
uniprot
B4DZJ4
resolver
uniprot
D3DNU1
resolver
uniprot
Q05BY6
resolver
uniprot
Q15450
resolver
uniprot
Q2NKN3
resolver
uniprot_entry
M3K13_HUMAN
resolver
uniprot_sec
B2R6U2
resolver
uniprot_sec
B4DLE3
resolver
uniprot_sec
B4DMV2
resolver
uniprot_sec
B4DZJ4
resolver
uniprot_sec
D3DNU1
resolver
uniprot_sec
Q05BY6
resolver
uniprot_sec
Q15450
resolver
uniprot_sec
Q2NKN3
resolver
activity_regulation
ACTIVITY REGULATION: Activated by autophosphorylation and homodimerization. {ECO:0000269|PubMed:11163770, ECO:0000269|PubMed:9353328}.
uniprot
proteins
amino_acid_sequence
MANFQEHLSCSSSPHLPFSESKTFNGLQDELTAMGNHPSPKLLEDQQEKGMVRTELIESVHSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGECSDATVRTNKHYSSATW
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}.
uniprot
proteins
mass_dalton
108296
uniprot
proteins
mutagenesis
MUTAGEN 195; /note="K->A: Kinase inactive. Fails to activate NF-kappa-B."; /evidence="ECO:0000269|PubMed:12492477
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on serine and threonine residues. {ECO:0000269|PubMed:9353328}.
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
11163770
uniprot
proteins
pubmed
11726277
uniprot
proteins
pubmed
12492477
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
8274451
uniprot
proteins
pubmed
9353328
uniprot
proteins
sequence_length
966
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9353328}. Membrane {ECO:0000269|PubMed:9353328}; Peripheral membrane protein {ECO:0000269|PubMed:9353328}.
uniprot
proteins