P59242
uniprot
P59242
canonical
amino_acid_sequence
MADPRGPVDHGVQIRFITEPEGATEMGTLRRSGRRPARDARASTYGVAVRVQGIAGQPFVVLNSGEKGTDSFGVQIKGGNNRGSPGALSSDSELPENPYSQVKGRPATSRSSTSDEEPKDHLNGKLIRSQSQASLTGLAFMSPSNRSTSLLELAPKPTSSINTIDTAPLSSVDSLINKFDSQKGGQVRGRTGRRTRTLPHEQRKRSQSLDSRLPRDTREEREHQSANHWTRGTKYDNHVDSSKNPSQKQSPFSSFSRSRQTQDWVLQSFEETRDPAMVQFKSTPDLLRDQRETAPPGSADHVKATIYGILREGSSESEASVRRKVSLVLEQMQPLGMVSPASTKALAGQAELTRKMEELQKKLDEEVKKRQKLEPSRVGLERQLEEKAEECHRLQELLERRKGEVQQSSKELQNMKLLLGQEEGLRHGLEAQVKELQLKLKHSQSPDSGKESLLKDLLDTRELLEELLEGKQRVEEQLRLRERELTALKGALKEEVASHDQEVEHVRLQYQRDTEQLRRSMQDATQDHAALEAERQKMSSLVRELQRELEETSEETGHWQSMFQKNKEELRATKQELLQLRMEKEEMEEELGEKMEVLQRDLEQARASTRDTHQVEELKKELRRTQGELKELQAEQQNQEVTGRHRNQVLEKQLAALREEADRGRELEQQNLQLQKTLQQLRQDCEEASKAKVASETEAMMLGQRRATVETTLRETQEENDEFRRRILGLEQQLKEARGLAEGGEAVEARLRDKVHRLEVEKQQLEEALNAAQEEEGNLAAAKRALEVRLDEAQRGLARLGQEQQALNRALEEEGKQREALRRSKAELEEQKRLLNRTVDRLNKELEQIGDDSKLALQQLQAQMEDYKEKARKEVADAQRQAKDWASEAEKNSGGLSRLQDELQRLRQALQTSQAERDTARLDKELLAQRLQGLEQEAENKKRFQDDKARQLKSLEEKVSRLEAELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERRVKELSIQIDDERQHVNDQKDQLTLRVKALKRQVDEAEEEIERLDSLRKKAQRELEEQHEVNEQLQARIKSLEKDAWRKASRSAAESALKQEGLSSDEEFDNVYDPSSIASLLTESNLQTSSC
uniprot
proteins
function
FUNCTION: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. {ECO:0000250}.
uniprot
proteins
mass_dalton
136447
uniprot
proteins
protein_family
Cingulin family
uniprot
proteins
pubmed
15292197
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:15292197}. Note=Localizes to the apical junction complex composed of tight and adherens junction (PubMed:15292197). Colocalizes with SPEF1 at sites of cell-cell contact in intestinal epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q9P2M7, ECO:0000269|PubMed:15292197}.
uniprot
proteins