ARSI
entrez
340075
canonical
uniprot
Q5FYB1
canonical
ensembl
ENSG00000183876
resolver
ensp
ENSP00000333395
resolver
genesymbol
ARSI
resolver
hgnc
HGNC:32521
resolver
uniprot
A1L3B0
resolver
uniprot
B3KV22
resolver
uniprot
B7XD03
resolver
uniprot_entry
ARSI_HUMAN
resolver
uniprot_sec
A1L3B0
resolver
uniprot_sec
B3KV22
resolver
uniprot_sec
B7XD03
resolver
amino_acid_sequence
MHTLTGFSLVSLLSFGYLSWDWAKPSFVADGPGEAGEQPSAAPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDLAGQRPDVVRTLLARLAEYNRTAIPVRYPAENPRAHPDFNGGAWGPWASDEEEEEEEGRARSFSRGRRKKKCKICKLRSFFRKLNTRLMSQRI
uniprot
proteins
ec_number
3.1.6.-
uniprot
proteins
function
FUNCTION: Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts (PubMed:19262745). Lacks arylsulfatase activity (PubMed:16500042). {ECO:0000269|PubMed:16500042, ECO:0000269|PubMed:19262745}.
uniprot
proteins
mass_dalton
64030
uniprot
proteins
mutagenesis
MUTAGEN 93; /note="C->S: No arylsulfatase activity in the media of retinal epithelium cell."; /evidence="ECO:0000269|PubMed:19262745
uniprot
proteins
post_translational_modification
PTM: The oxidation of Cys-93 residue to 3-oxoalanine (also known as C(alpha)-formylglycine) by SUMF1/Sulfatase-modifying factor 1, seems critical for catalytic activity. {ECO:0000269|PubMed:19262745}.
uniprot
proteins
protein_family
Sulfatase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16174644
uniprot
proteins
pubmed
16500042
uniprot
proteins
pubmed
19262745
uniprot
proteins
sequence_length
569
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19262745}. Endoplasmic reticulum {ECO:0000269|PubMed:19262745}. Note=Localized in the intracellular granular structures.
uniprot
proteins