MOV10
entrez
4343
canonical
uniprot
Q9HCE1
canonical
ensembl
ENSG00000155363
resolver
ensp
ENSP00000350028
resolver
ensp
ENSP00000358658
resolver
ensp
ENSP00000358659
resolver
ensp
ENSP00000399797
resolver
ensp
ENSP00000510374
resolver
ensp
ENSP00000555082
resolver
ensp
ENSP00000643539
resolver
ensp
ENSP00000730843
resolver
enst
ENST00000369644
resolver
genesymbol
MOV10
resolver
genesymbol_syn
KIAA1631
resolver
hgnc
HGNC:7200
resolver
uniprot
Q5JR03
resolver
uniprot
Q5JR04
resolver
uniprot
Q8TEF0
resolver
uniprot
Q9BSY3
resolver
uniprot
Q9BUJ9
resolver
uniprot_entry
MOV10_HUMAN
resolver
uniprot_entry
Q5JR04_HUMAN
resolver
uniprot_sec
Q5JR03
resolver
uniprot_sec
Q8TEF0
resolver
uniprot_sec
Q9BSY3
resolver
uniprot_sec
Q9BUJ9
resolver
amino_acid_sequence
MPSKFSCRQLREAGQCFESFLVVRGLDMETDRERLRTIYNRDFKISFGTPAPGFSSMLYGMKIANLAYVTKTRVRFFRLDRWADVRFPEKRRMKLGSDISKHHKSLLAKIFYDRAEYLHGKHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGGTQSVTLTHLFPLCRTPQFAFYNEDQELPCPLGPGECYELHVHCKTSFVGYFPATVLWELLGPGESGSEGAGTFYIARFLAAVAHSPLAAQLKPMTPFKRTRITGNPVVTNRIEEGERPDRAKGYDLELSMALGTYYPPPRLRQLLPMLLQGTSIFTAPKEIAEIKAQLETALKWRNYEVKLRLLLHLEELQMEHDIRHYDLESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSETHQEDPITYKGFVHKVELDRVKLSFSMSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWLLWPMLFPVAPRDVPLLPSDVKLKLYDRSLESNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKPCCNWDAKKGEYVFPAKKKLQEYRVLITTLITAGRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMEVKETGDPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDGYDPQFITKLLRNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIIVGNPLLLGHDPDWKVFLEFCKENGGYTGCPFPAKLDLQQGQNLLQGLSKLSPSTSGPHSHDYLPQEREGEGGLSLQVEPEWRNEL
uniprot
proteins
ec_number
5.6.2.5
uniprot
proteins
function
FUNCTION: 5'-3' RNA helicase (PubMed:24726324). Involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:27974568, PubMed:35157734). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Also inhibits hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:23093941, PubMed:30122351). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:20215113, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:23093941, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:27016603, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:29258557, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31722967, ECO:0000269|PubMed:35157734}.; FUNCTION: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269|PubMed:18552826}.
uniprot
proteins
mass_dalton
113671
uniprot
proteins
mutagenesis
MUTAGEN 129; /note="Q->A: About 70% more antiviral activity against encephalomyocarditis virus replication; when associated with A-869."; /evidence="ECO:0000269|PubMed:27016603"; MUTAGEN 530; /note="K->A: Abolishes 5' to 3' directional unwinding activity. Abolishes inhibition of RNA chaperonne activity of LIRE1. No effect on interaction with UPF1."; /evidence="ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:30122351"; MUTAGEN 530; /note="K->R: Attenuated anti-HBV activity."; /evidence="ECO:0000269|PubMed:31722967"; MUTAGEN 645; /note="D->N: Abolishes 5' to 3' directional unwinding activity."; /evidence="ECO:0000269|PubMed:24726324"; MUTAGEN 646; /note="E->Q: Almost complete loss of the ability to prevent the degradation of APOBEC3G mediated by HIV-1 Vif. Attenuated anti-HBV activity."; /evidence="ECO:0000269|PubMed:29258557, ECO:0000269|PubMed:31722967"; MUTAGEN 869; /note="Q->A: About 70% more antiviral activity against encephalomyocarditis virus replication; when associated with A-129."; /evidence="ECO:0000269|PubMed:27016603"; MUTAGEN 1002; /note="E->X: Loss of interaction with DCAF12 and proteasomal degradation."; /evidence="ECO:0000269|PubMed:34065512
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the DCX(DCAF12) complex that specifically recognizes the glutamate-leucine (Glu-Leu) degron at the C-terminus, leading to its degradation. {ECO:0000269|PubMed:34065512}.; PTM: (Microbial infection) Cleaved and targeted for degradation by picornavirus proteases. {ECO:0000269|PubMed:27016603}.
uniprot
proteins
protein_family
DNA2/NAM7 helicase family
uniprot
proteins
protein_family
SDE3 subfamily
uniprot
proteins
pubmed
10997877
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16289642
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17507929
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18552826
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20215113
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22791714
uniprot
proteins
pubmed
23093941
uniprot
proteins
pubmed
23125361
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24726324
uniprot
proteins
pubmed
25220460
uniprot
proteins
pubmed
25464849
uniprot
proteins
pubmed
27016603
uniprot
proteins
pubmed
27974568
uniprot
proteins
pubmed
29258557
uniprot
proteins
pubmed
30122351
uniprot
proteins
pubmed
31722967
uniprot
proteins
pubmed
34065512
uniprot
proteins
pubmed
35157734
uniprot
proteins
sequence_length
1003
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:30122351}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:30122351}. Cytoplasm, Stress granule {ECO:0000269|PubMed:23093941}. Nucleus {ECO:0000250|UniProtKB:P23249}. Cytoplasm {ECO:0000250|UniProtKB:P23249}. Note=Co-enriched in cytoplasmic foci with TUT4 (PubMed:30122351). In developing neurons, localizes both in nucleus and cytoplasm, but in the adulthood it is only cytoplasmic (By similarity). After infection, relocalizes to the DENV replication complex in perinuclear regions (PubMed:27974568). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:30122351}.
uniprot
proteins