IL13RA2
entrez
3598
canonical
uniprot
Q14627
canonical
ensembl
ENSG00000123496
resolver
ensp
ENSP00000243213
resolver
ensp
ENSP00000361004
resolver
ensp
ENSP00000628062
resolver
enst
ENST00000243213
resolver
enst
ENST00000371936
resolver
enst
ENST00000958003
resolver
genesymbol
IL13RA2
resolver
genesymbol_syn
IL13R
resolver
hgnc
HGNC:5975
resolver
uniprot
A8K7E2
resolver
uniprot
O00667
resolver
uniprot_entry
I13R2_HUMAN
resolver
uniprot_sec
A8K7E2
resolver
uniprot_sec
O00667
resolver
amino_acid_sequence
MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLDHFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQSSWAETTYWISPQGIPETKVQDMDCVYYNWQYLLCSWKPGIGVLLDTNYNLFYWYEGLDHALQCVDYIKADGQNIGCRFPYLEASDYKDFYICVNGSSENKPIRSSYFTFQLQNIVKPLPPVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTATVENETYTLKTTNETRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLRFWLPFGFILILVIFVTGLLLRKPNTYPKMIPEFFCDT
uniprot
proteins
function
FUNCTION: Cell surface receptor that plays a role in the regulation of IL-13-mediated responses (PubMed:11861389, PubMed:17030238). Functions as a decoy receptor that inhibits IL-13- and IL-4-mediated signal transduction via the JAK-STAT pathway and thereby modulates immune responses and inflammation (PubMed:11861389, PubMed:17030238). Serves as a functional signaling receptor for IL-13 in an alternative pathway involving AP-1 ultimately leading to the production of TGFB1 (PubMed:16327802). {ECO:0000269|PubMed:11861389, ECO:0000269|PubMed:16327802, ECO:0000269|PubMed:17030238, ECO:0000269|PubMed:20223216}.
uniprot
proteins
mass_dalton
44176
uniprot
proteins
post_translational_modification
PTM: Cleaved by MMP8 leading to a soluble form that is also able to interact with IL13. {ECO:0000269|PubMed:18694590}.
uniprot
proteins
protein_family
Type 5 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
11861389
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16327802
uniprot
proteins
pubmed
17030238
uniprot
proteins
pubmed
18694590
uniprot
proteins
pubmed
20223216
uniprot
proteins
pubmed
8663118
uniprot
proteins
pubmed
9177784
uniprot
proteins
sequence_length
380
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18694590}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 344..363; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins