Rin1
entrez
225870
canonical
uniprot
Q921Q7
canonical
ensembl
ENSMUSG00000024883
resolver
ensp
ENSMUSP00000025818
resolver
ensp
ENSMUSP00000153189
resolver
ensp
ENSMUSP00000193433
resolver
enst
ENSMUST00000025818
resolver
enst
ENSMUST00000225427
resolver
genesymbol
Rin1
resolver
uniprot
A0A2C9F2A2
resolver
uniprot_entry
A0A2C9F2A2_MOUSE
resolver
uniprot_entry
RIN1_MOUSE
resolver
amino_acid_sequence
MEDPGETGAHPLGATNLNFVPGHQQKEKPSTDPLYDTPDTRGVQAGGSQQPARTVSLRERLLITRPVWLQLRANAAAALHVLRTEPPGTFLVRKSNTRQCQALCVRLPEASGPSFVSSHYIEESTGGVSLEGSELMFQDLVQLICGYCRTRAIHQAATHKELEAISHLGMEFWSSSLNTKDQQRPSEAPPIPRLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGTSSSQTERLPPRQLLQRESSVGYRVPGSAASPCLPPLPSLQEVDCCSPSSSEEEGSSGSPTTSPRLSRPRHRRPLLRSMSSAFCSLLAPERQVGRAATMLMQNRYTAVGQLVQDLLTQVRAGPEPRELQGIRQALSRARAMLSAELGPEKLLPPERLELVLEKSLHRSVLKPLRPILAARLRRRLSADGSLGRLAEGFRLARTQGPGAFGSHLTLSSPVETEQVRQKLLQLLRAYSPSAQVKWLLQACKLLYTALKSQAGENAGADEFLPLLSLVLAQCDLPDLLLEAEYMSELLEPTLLTGEGGYYLTSLSASLALLSGLSQARALPLSPAQELQRSLALWEQRRLPATHSFQHLLRVAYQDPSTGCTSKTLAVPPGSSIATLSQLCATKFRVTQPDAFGLFLYKDQGYHRLPPEALAHRLPATGYLIYRRAERPETQGAVAEKAKTGSKGPEAGAWEEETGGLNREGKPRIAVDQEGKDQARGGHIGPEEQKAEGSQALEE
uniprot
proteins
function
FUNCTION: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:12574403}.
uniprot
proteins
mass_dalton
83014
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-340 by PRKD1 induces interaction with 14-3-3 proteins (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
RIN (Ras interaction/interference) family
uniprot
proteins
pubmed
12574403
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
763
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Some amount is membrane-associated. {ECO:0000250}.
uniprot
proteins