Ncoa2
entrez
83724
canonical
uniprot
Q9WUI9
canonical
ensembl
ENSRNOG00000007975
resolver
ensp
ENSRNOP00000011026
resolver
ensp
ENSRNOP00000093156
resolver
enst
ENSRNOT00000011026
resolver
enst
ENSRNOT00000119206
resolver
genesymbol
Ncoa2
resolver
genesymbol_syn
Tif2
resolver
uniprot
A0A8I6AJ68
resolver
uniprot
F1MA61
resolver
uniprot_entry
A0A8I6AJ68_RAT
resolver
uniprot_entry
F1MA61_RAT
resolver
uniprot_entry
NCOA2_RAT
resolver
amino_acid_sequence
MSGMGENTSDPSRAETRKRKECPDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSMVNGGSWTGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDKQSCLICVARRVPMKERPALPSSESFTTRQDLQGKITFLDTSTMRDAMKPGWEDLVRRCIQKFHTQHEGESLSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISIHMLHREQNVCVMNPDLTGQAMGKPLSPMSSSSPARQAMCSGNPGQDVALGSNMNFPMNGPREQMSMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGLNPGQPSSVLSPRHRMSPGVAGSPRVPPSQFSPAGSLHSPAGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGPSLASPDLKMGNSQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAQASCHPEEQKRPNDSSMPQAASEDRAEGHSRLHESKGQTKLLQLLTTKSDQMEPSPLPSSLSDTNKDSTGSLPGPGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELNQESSGTAPGSEVTVKQEPASPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTVKEEVSFEPSDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPTGSVDKQAIINDLMQLTADSSPVTPVGAQKAALRMSQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMLGSQGNLGNNSTGMIGSSTSRSSMPSGEWAPQSPAVRVTCAATTGAMNRPIQGGMIRNPTASIPMRANSQPGQRQMLQPQVMNIGPSELEMNMGGPQYNQQQAPPNQTAPWPESILPIDQASFGSQNRHPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQESSMMLEQKPPVFPQQYASQTQMAQGSYNPMQDPNFHTMGQRPNYTTLRMQPRPGLRPTGIVQNQPNQLRLQLQHRLQAQQNRQPLMNQISGVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPTGLPAAMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQPASDINGWAQGSMGGNSMFSQQSPPHFGQQANTSMYNNNMNINVSMATNTAGLSNMNQMTGQMSMTSVTSVPTSGLSSMGPEQVNDPALRGSSLFTTNQLPGMDMIKQEGDGSRKYC
uniprot
proteins
function
FUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer. {ECO:0000250|UniProtKB:Q15596, ECO:0000250|UniProtKB:Q61026}.
uniprot
proteins
mass_dalton
159436
uniprot
proteins
post_translational_modification
PTM: Acetylated. Deacetylation at Lys-780 by SIRT6 stimulates its ability to coactivate PPARA. {ECO:0000250|UniProtKB:Q61026}.
uniprot
proteins
protein_family
SRC/p160 nuclear receptor coactivator family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9742117
uniprot
proteins
sequence_length
1465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15596}.
uniprot
proteins