TFEC
entrez
22797
canonical
uniprot
O14948
canonical
ensembl
ENSG00000105967
resolver
ensp
ENSP00000265440
resolver
ensp
ENSP00000318676
resolver
ensp
ENSP00000387650
resolver
ensp
ENSP00000417432
resolver
ensp
ENSP00000622307
resolver
genesymbol
TFEC
resolver
genesymbol_syn
BHLHE34
resolver
genesymbol_syn
TCFEC
resolver
genesymbol_syn
TFECL
resolver
hgnc
HGNC:11754
resolver
uniprot
B2R8X5
resolver
uniprot
Q5H9U8
resolver
uniprot
Q709A4
resolver
uniprot
Q8N6J9
resolver
uniprot_entry
TFEC_HUMAN
resolver
uniprot_sec
B2R8X5
resolver
uniprot_sec
Q5H9U8
resolver
uniprot_sec
Q709A4
resolver
uniprot_sec
Q8N6J9
resolver
amino_acid_sequence
MTLDHQIINPTLKWSQPAVPSGGPLVQHAHTTLDSDAGLTENPLTKLLAIGKEDDNAQWHMEDVIEDIIGMESSFKEEGADSPLLMQRTLSGSILDVYSGEQGISPINMGLTSASCPSSLPMKREITETDTRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRRLLLRIQELEIQARTHGLPTLASLGTVDLGAHVTKQQSHPEQNSVDYCQQLTVSQGPSPELCDQAIAFSDPLSYFTDLSFSAALKEEQRLDGMLLDDTISPFGTDPLLSATSPAVSKESSRRSSFSSDDGDEL
uniprot
proteins
function
FUNCTION: Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form. {ECO:0000250, ECO:0000269|PubMed:11467950, ECO:0000269|PubMed:9256061}.
uniprot
proteins
mass_dalton
38788
uniprot
proteins
protein_family
MiT/TFE family
uniprot
proteins
pubmed
11467950
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15118077
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
9256061
uniprot
proteins
sequence_length
347
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11467950}.
uniprot
proteins