Gabrd
entrez
14403
canonical
uniprot
P22933
canonical
ensembl
ENSMUSG00000029054
resolver
ensp
ENSMUSP00000030925
resolver
ensp
ENSMUSP00000234079
resolver
ensp
ENSMUSP00000234080
resolver
ensp
ENSMUSP00000234092
resolver
enst
ENSMUST00000030925
resolver
genesymbol
Gabrd
resolver
uniprot
Q14AH9
resolver
uniprot_entry
GBRD_MOUSE
resolver
uniprot_entry
Q14AH9_MOUSE
resolver
amino_acid_sequence
MDVLGWLLLPLLLLCTQPHHGARAMNDIGDYVGSNLEISWLPNLDGLMEGYARNFRPGIGGAPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPLDEQECMLDLESYGYSSEDIVYYWSENQEQIHGLDRLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFQLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKRKAKVKVTKPRAEMDVRNAIVLFSLSAAGVSQELAISRRQGRVPGNLMGSYRSVEVEAKKEGGSRPGGPGGIRSRLKPIDADTIDIYARAVFPAAFAAVNIIYWAAYTM
uniprot
proteins
function
FUNCTION: Delta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABAARs containing delta/GABRD subunits are predominantly expressed and located in extrasynaptic or perisynaptic positions on hippocampus and cerebellar granule cells, and contribute to the tonic GABAergic inhibition (By similarity). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity). {ECO:0000250|UniProtKB:O14764, ECO:0000250|UniProtKB:P18506}.
uniprot
proteins
mass_dalton
50522
uniprot
proteins
protein_family
GABRD sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
1324097
uniprot
proteins
pubmed
2176788
uniprot
proteins
sequence_length
449
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P18506}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14764}.
uniprot
proteins
transmembrane_region
TRANSMEM 252..271; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O14764"; TRANSMEM 276..298; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O14764"; TRANSMEM 309..331; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O14764"; TRANSMEM 424..446; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O14764
uniprot
proteins