Plcd4
entrez
18802
canonical
uniprot
Q8K3R3
canonical
ensembl
ENSMUSG00000026173
resolver
ensp
ENSMUSP00000027362
resolver
ensp
ENSMUSP00000109376
resolver
ensp
ENSMUSP00000250768
resolver
ensp
ENSMUSP00000250769
resolver
ensp
ENSMUSP00000250780
resolver
ensp
ENSMUSP00000250797
resolver
genesymbol
Plcd4
resolver
genesymbol_syn
Plcd
resolver
uniprot
Q3USN9
resolver
uniprot
Q6NZF7
resolver
uniprot
Q8CAB1
resolver
uniprot
Q9CUC1
resolver
uniprot_entry
PLCD4_MOUSE
resolver
uniprot_sec
Q3USN9
resolver
uniprot_sec
Q6NZF7
resolver
uniprot_sec
Q8CAB1
resolver
uniprot_sec
Q9CUC1
resolver
amino_acid_sequence
MTSQIQDLLATDQDLLLMQEGTMMRKVRTKSWKKLRYFRLQNDGMTVWHGSQPESMPKPTFSISDVERIRKGQDSELLRYLVEEFPLEQGFTVVFHGRRPNLDLVANSVEEAQIWMRGLQLLVDLVASMDHQEQMDQMLNEWFQQADRNQDGRMSFREAQRLLLLMNVEMDEEYAFSLFQEADVTQSDDLGSEEFVQFYKALTKRTEIEEIFEDFSSDKQKLTLLEFVDFLRKEQKEKDHAPDLALELIDRYEPSENGRLLHVLSKDGFLKYLCSKDGNIFNSDCLPIYQDMTQPLSHYYINSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDTWDGPDGEPVVYHGHTLTSRILFKDVLATLAQYAFQSSDYPLILSLENHCTWEQQRTMAHHLTEILGEQLLRNTLEGLLVDSMPSPEQLRGKILVKGKKLRTIEVDKEEEEEEEEEELEKDEGPDLDPASPELDTQPQPETQGQAAGNKKERKKKVMKCPMSCLLICGHVMAQAPSSIPESILLSKQFLLLSSTTIMCPDLSALVVYLRTVPFCSFTHSKENYHIYDISSFSESKAKNLIKEAGNEFVQHNARQLCRVYPSGLRTDSSNFNPQEHWNVGCQMVAMNMQTAGSAMDICDGLFRQNGGSGYVLKPEFLRDTQSSFNPERPISLYKAQILVVQVISGQQLPKVDKTKETTVVDPLVKVELYGVPEDTKEQETSHVENNGINPYWGETFYFRLQVPELAMLRFVVKDYSRKSRNNFIGQYTLPWTCMKQGYRHVSLLSRDGTSLNPASIFVYTCMQEDLDMDEP
uniprot
proteins
ec_number
3.1.4.11
uniprot
proteins
function
FUNCTION: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. {ECO:0000269|PubMed:11340203, ECO:0000269|PubMed:12695499, ECO:0000269|PubMed:16998201}.
uniprot
proteins
mass_dalton
92694
uniprot
proteins
pubmed
10601847
uniprot
proteins
pubmed
11340203
uniprot
proteins
pubmed
12695499
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16272139
uniprot
proteins
pubmed
16998201
uniprot
proteins
sequence_length
807
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q62711}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62711}; Cytoplasmic side {ECO:0000250|UniProtKB:Q62711}. Nucleus {ECO:0000250|UniProtKB:Q62711}. Cytoplasm {ECO:0000250|UniProtKB:Q9BRC7}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q62711}. Note=The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes (By similarity). Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q62711}.
uniprot
proteins