Cradd
entrez
12905
canonical
uniprot
O88843
canonical
ensembl
ENSMUSG00000045867
resolver
ensp
ENSMUSP00000050295
resolver
ensp
ENSMUSP00000151735
resolver
ensp
ENSMUSP00000152022
resolver
ensp
ENSMUSP00000223949
resolver
ensp
ENSMUSP00000223950
resolver
ensp
ENSMUSP00000223951
resolver
ensp
ENSMUSP00000223953
resolver
ensp
ENSMUSP00000223955
resolver
ensp
ENSMUSP00000347995
resolver
enst
ENSMUST00000053594
resolver
enst
ENSMUST00000217809
resolver
enst
ENSMUST00000220279
resolver
genesymbol
Cradd
resolver
genesymbol_syn
Raidd
resolver
uniprot
Q3UMW0
resolver
uniprot
Q549T4
resolver
uniprot
Q9QUN0
resolver
uniprot_entry
CRADD_MOUSE
resolver
uniprot_entry
Q3UMW0_MOUSE
resolver
uniprot_entry
Q549T4_MOUSE
resolver
uniprot_sec
Q9QUN0
resolver
amino_acid_sequence
MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEIKAQTTGLRKTMLLLDILPSRGPKAFDTFLDSLQEFPWVREKLEKAREEVTAELPTGDWMAGIPSHILSSSPSDQQINQLAQRLGPEWEPVVLSLGLSQTDIYRCKANHPHNVHSQVVEAFVRWRQRFGKQATFLSLHKGLQAVEADPSLLQHMLE
uniprot
proteins
function
FUNCTION: Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway. {ECO:0000250|UniProtKB:P78560}.
uniprot
proteins
mass_dalton
22656
uniprot
proteins
mutagenesis
MUTAGEN 128; /note="G->R: Impairs the interaction with PIDD."; /evidence="ECO:0000269|PubMed:22279524
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22279524
uniprot
proteins
pubmed
9806843
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22279524}. Nucleus {ECO:0000269|PubMed:22279524}.
uniprot
proteins