Trub2
entrez
366012
canonical
uniprot
Q5XFW2
canonical
ensembl
ENSRNOG00000043189
resolver
ensp
ENSRNOP00000063203
resolver
enst
ENSRNOT00000064638
resolver
genesymbol
Trub2
resolver
uniprot_entry
TRUB2_RAT
resolver
amino_acid_sequence
MGSSGLARLQGLFAVYKPPGLKWLHVRETVELQLLKGLNAQQPSAPEQHVRFLLGPVEGSEEKKLTLTATSVPSLTTHRLVRGPAFRNLKIGVGHRLDVQASGVLVLAVGHGRSLLTDMYDAHLTKDYTVRGLLGKATDNFCEDGQLIEKTTYDHVTRERLDRILAMIQGSHQKALVMYSNLDLKSQEAYERAVQGVIRPMNKSPMLIAGIRCLHFAPPEFLLEVQCMHETQQQLRRLVHEIGLELKTTAVCMQVRRTRDGFFGLDDALLRTQWDLHSIQDAIQTAAPRVARELRKNLSLMSGHQQQLPSAGQPWASRVQAPL
uniprot
proteins
ec_number
5.4.99.-
uniprot
proteins
ec_number
5.4.99.25
uniprot
proteins
function
FUNCTION: Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. {ECO:0000250|UniProtKB:O95900}.
uniprot
proteins
mass_dalton
36109
uniprot
proteins
protein_family
Pseudouridine synthase TruB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:O95900}. Note=Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. {ECO:0000250|UniProtKB:O95900}.
uniprot
proteins