CIRBP
entrez
1153
canonical
uniprot
Q14011
canonical
ensembl
ENSG00000099622
resolver
ensp
ENSP00000322887
resolver
ensp
ENSP00000464906
resolver
ensp
ENSP00000465077
resolver
ensp
ENSP00000465558
resolver
ensp
ENSP00000466025
resolver
ensp
ENSP00000466110
resolver
ensp
ENSP00000466897
resolver
ensp
ENSP00000467449
resolver
ensp
ENSP00000467734
resolver
ensp
ENSP00000467848
resolver
ensp
ENSP00000467948
resolver
ensp
ENSP00000468645
resolver
ensp
ENSP00000486590
resolver
ensp
ENSP00000578711
resolver
ensp
ENSP00000586954
resolver
ensp
ENSP00000586955
resolver
ensp
ENSP00000586957
resolver
ensp
ENSP00000622665
resolver
ensp
ENSP00000622666
resolver
enst
ENST00000585913
resolver
enst
ENST00000585914
resolver
enst
ENST00000586636
resolver
enst
ENST00000586773
resolver
enst
ENST00000587323
resolver
enst
ENST00000587896
resolver
enst
ENST00000588230
resolver
enst
ENST00000589235
resolver
enst
ENST00000589710
resolver
enst
ENST00000591935
resolver
enst
ENST00000628979
resolver
enst
ENST00000908652
resolver
enst
ENST00000916895
resolver
enst
ENST00000916896
resolver
enst
ENST00000916898
resolver
enst
ENST00000952606
resolver
enst
ENST00000952607
resolver
genesymbol
CIRBP
resolver
genesymbol_syn
A18HNRNP
resolver
genesymbol_syn
CIRP
resolver
hgnc
HGNC:1982
resolver
uniprot
B3KT17
resolver
uniprot
B4E2X2
resolver
uniprot
D6W5Y5
resolver
uniprot
K7EPM4
resolver
uniprot
K7EQR7
resolver
uniprot
Q53XX5
resolver
uniprot_entry
CIRBP_HUMAN
resolver
uniprot_entry
D6W5Y5_HUMAN
resolver
uniprot_entry
K7EPM4_HUMAN
resolver
uniprot_entry
K7EQR7_HUMAN
resolver
uniprot_entry
Q53XX5_HUMAN
resolver
uniprot_sec
B3KT17
resolver
uniprot_sec
B4E2X2
resolver
amino_acid_sequence
MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGDRGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYATHNE
uniprot
proteins
function
FUNCTION: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. {ECO:0000250, ECO:0000269|PubMed:11574538, ECO:0000269|PubMed:16513844}.
uniprot
proteins
mass_dalton
18648
uniprot
proteins
post_translational_modification
PTM: Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity). {ECO:0000250}.; PTM: Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation. {ECO:0000269|PubMed:16513844}.
uniprot
proteins
pubmed
11574538
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15075239
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16513844
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9334257
uniprot
proteins
pubmed
9434172
uniprot
proteins
sequence_length
172
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:11574538}. Cytoplasm {ECO:0000269|PubMed:11574538}. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity). {ECO:0000250}.
uniprot
proteins