Abi2
entrez
329165
canonical
uniprot
P62484
canonical
ensembl
ENSMUSG00000026782
resolver
ensp
ENSMUSP00000058754
resolver
ensp
ENSMUSP00000139867
resolver
ensp
ENSMUSP00000140274
resolver
ensp
ENSMUSP00000140750
resolver
ensp
ENSMUSP00000141068
resolver
ensp
ENSMUSP00000165272
resolver
ensp
ENSMUSP00000165288
resolver
ensp
ENSMUSP00000165299
resolver
ensp
ENSMUSP00000333418
resolver
ensp
ENSMUSP00000333420
resolver
enst
ENSMUST00000052332
resolver
enst
ENSMUST00000187709
resolver
enst
ENSMUST00000188594
resolver
enst
ENSMUST00000188618
resolver
enst
ENSMUST00000189980
resolver
genesymbol
Abi2
resolver
uniprot
A0A087WPP8
resolver
uniprot
A0A087WQN4
resolver
uniprot
A0A087WRS3
resolver
uniprot
A0A087WSJ1
resolver
uniprot
Q6AXD2
resolver
uniprot
Q6AXH6
resolver
uniprot
Q6PHU3
resolver
uniprot_entry
A0A087WPP8_MOUSE
resolver
uniprot_entry
A0A087WQN4_MOUSE
resolver
uniprot_entry
A0A087WRS3_MOUSE
resolver
uniprot_entry
A0A087WSJ1_MOUSE
resolver
uniprot_entry
ABI2_MOUSE
resolver
uniprot_entry
Q6AXD2_MOUSE
resolver
uniprot_entry
Q6AXH6_MOUSE
resolver
uniprot_sec
Q6PHU3
resolver
amino_acid_sequence
MAELQMLLEEEIPGGRRALFDSYTNLERVADYCENNYIQSPDKQRALEETKAYTTQSLASVAYLINTLANNVLQMLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANLERPVRYIRKPIDYTILDDIGHGVKVSTQNMKMGGLPRTTPPTQKPPSPPMSGKGTLGRHSPYRTLEPVRPPVVPNDYVPSPTRNMAPSQQSPVRTASVNQRNRTYSSSGSSGGSHPSSRSSSRENSGSGSVGVPIAVPTPSPPSVFPGHPVQFYSMNRPASRHTPPTIGGSLPYRRPPSITSQTSLQNQMNGGPFYNQNPVSDTPPPPPPVEEPVFDESPPPPPPPEDYEEEEAAVVEYSDPYAEEDPPWAPRAYLEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEGVMNGVTGLFPGNYVESIMHYSE
uniprot
proteins
function
FUNCTION: Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (By similarity). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (By similarity). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (PubMed:15572692). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (PubMed:27605705). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (PubMed:15572692). Also required for nascent adherens junction assembly in epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q9NYB9, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:27605705}.
uniprot
proteins
mass_dalton
49387
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ABL1. {ECO:0000250|UniProtKB:Q9NYB9}.
uniprot
proteins
protein_family
ABI family
uniprot
proteins
pubmed
10995551
uniprot
proteins
pubmed
11516653
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15572692
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27605705
uniprot
proteins
sequence_length
446
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, lamellipodium {ECO:0000269|PubMed:11516653}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9NYB9}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9NYB9}. Cell junction, adherens junction {ECO:0000269|PubMed:15572692}. Cell projection, dendritic spine {ECO:0000269|PubMed:15572692}. Note=Localized to the protruding lamellipodia and filopodia tips (By similarity). Present at nascent adherens junctions where it clusters adjacent to the tips of F-actin protrusions (By similarity). {ECO:0000250|UniProtKB:Q9NYB9}.
uniprot
proteins