Spindoc
entrez
68229
canonical
uniprot
Q05AH6
canonical
ensembl
ENSMUSG00000024970
resolver
ensp
ENSMUSP00000025924
resolver
ensp
ENSMUSP00000184771
resolver
ensp
ENSMUSP00000338405
resolver
genesymbol
Spindoc
resolver
uniprot
Q3TI49
resolver
uniprot
Q3TQH2
resolver
uniprot_entry
SPNDC_MOUSE
resolver
uniprot_sec
Q3TI49
resolver
uniprot_sec
Q3TQH2
resolver
amino_acid_sequence
MALKAKGAAALDCFEVTLKCEEGDDDDEAVVVAVIPRPEPMLRVTQQEKTPPPRPNLLEAGVEGCEELKQQVSWEQEFLVGNSPGGSGRALCMVCGAEIRSPSADTARAHILEQHPHTLDLSPSEKSNILEAWSEGVALLQDIQADQPSLPSLESGQDGQPDPISNPDPVRMPAEIVVLLDSEDNPSLPKRLRPRGLRPLELPVTPVIEQGNKKPRGQRWKESPENEPARKKRSRHMTKILDPDPDPPSPESPTETFAAPAEVRHFTDGSFPPGFVLQLFSHTQLRTTDCKDSSKDSRAAEGLPQPQNPSSASPPGLRGTLDLQVIRVRMEEPPAVSLLQDWSKHPQGTKGVGTGDKPDWPTVLSESSATVKGQPKAGSGV
uniprot
proteins
function
FUNCTION: Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (By similarity). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271). {ECO:0000250|UniProtKB:Q9BUA3, ECO:0000269|PubMed:34737271}.
uniprot
proteins
mass_dalton
41245
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29061846
uniprot
proteins
pubmed
34737271
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BUA3}. Chromosome {ECO:0000250|UniProtKB:Q9BUA3}. Note=Colocalizes with PARP1 to sites of DNA damage. {ECO:0000250|UniProtKB:Q9BUA3}.
uniprot
proteins