Pld2
entrez
25097
canonical
uniprot
P70498
canonical
ensembl
ENSRNOG00000019604
resolver
ensp
ENSRNOP00000053831
resolver
genesymbol
Pld2
resolver
uniprot
O08768
resolver
uniprot_entry
PLD2_RAT
resolver
uniprot_sec
O08768
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by phosphatidylinositol 4,5-bisphosphate and phosphatidylethanolamine. Inhibited by phosphatidylserine and by oleate. Is not responsive to ADP-ribosylation factor 1 (ARF1), nor to GTP-binding protein RhoA. {ECO:0000269|PubMed:9111050}.
uniprot
proteins
amino_acid_sequence
MTVTQTDLFPYGDYLNSSQLHMEPDVVDTLKEGEDPADRMHPFLAIYDLQPLRAHPLVFAPGVPVIAQVVGTERYTSGSKVGTCTLYSVRLTHGDFTWTTKKKFRHFQELHRDLQRHKVLMSLLNLARFAAAHSPAREAANENIPSLPRGGSEGSARHTASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGSKGLEGVIRKRSGGHRVPGFTCCGRDQVCYRWSKRWLVVKDSFLLYMRPETGAISFVQLFDPGFEVQVGKRSTEARYGVRIDTSHRSLILKCSSYRQARWWGQEITELAQGPGRDFLQLHQHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAREEIFITDWWLSPEIYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRTLMLLHPNIKVMRHPDLVTLWAHHEKLLVVDQAVAFLGGLDLAYGRWDDVQYRLTDLGDPSESADSQTPTPGSDPAATPDLSHNHFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGVAARDLARHFIQRWNFTKTIKARYKIPQYPYLLPKSASTANHLPFIIPGGQCATVQVLRSVDRWSAGTLESSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHEQGQCFRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYMSICGLRTHGELGGHPISELIYIHSKLLIADDRTVIIGSANINDRSLLGKRDSELAILIKDTEMEPSLMDGVEYQAGRFALSLRGRCFSVILGANTWPDLDLRDPVCDDFFQLWQETAENNATIYEQIFRCLPSNATRSLRALREYVAVESLATVSPSLAQSELAHIRGHLVHFPLKFLEDESLLPHWGAKRGMIPLEVWT
uniprot
proteins
ec_number
3.1.4.4
uniprot
proteins
function
FUNCTION: Function as phospholipase selective for phosphatidylcholine (By similarity) (PubMed:15282299, PubMed:9111050). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) (PubMed:15282299). {ECO:0000250|UniProtKB:P97813, ECO:0000269|PubMed:15282299, ECO:0000269|PubMed:9111050}.
uniprot
proteins
mass_dalton
106037
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FGR (PubMed:15282299). Phosphorylated on Tyr-11; most likely by EGFR (By similarity). {ECO:0000250|UniProtKB:P97813, ECO:0000269|PubMed:15282299}.
uniprot
proteins
protein_family
Phospholipase D family
uniprot
proteins
pubmed
15282299
uniprot
proteins
pubmed
8753790
uniprot
proteins
pubmed
9111050
uniprot
proteins
pubmed
9533024
uniprot
proteins
sequence_length
933
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P97813}; Lipid-anchor {ECO:0000250|UniProtKB:P97813}.
uniprot
proteins