Cox7b
entrez
303393
canonical
uniprot
P80431
canonical
ensembl
ENSRNOG00000054689
resolver
ensembl
ENSRNOG00055025872
resolver
ensembl
ENSRNOG00060022793
resolver
ensembl
ENSRNOG00065024860
resolver
ensp
ENSRNOP00000074109
resolver
ensp
ENSRNOP00055036547
resolver
ensp
ENSRNOP00060032738
resolver
ensp
ENSRNOP00065034963
resolver
enst
ENSRNOT00000090007
resolver
enst
ENSRNOT00055044642
resolver
enst
ENSRNOT00060039560
resolver
enst
ENSRNOT00065042708
resolver
genesymbol
Cox7b
resolver
uniprot
Q6AYA9
resolver
uniprot
Q7TPH1
resolver
uniprot_entry
COX7B_RAT
resolver
uniprot_sec
Q6AYA9
resolver
uniprot_sec
Q7TPH1
resolver
amino_acid_sequence
MLPLAKNALSRLQVRSIQQVVARQSHQKKTPTFHDKYGNAVLAGGSIFCISAWTYTATQIGIEWNLSPVGRVTPKEWRDQ
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (By similarity). Plays a role in proper central nervous system (CNS) development in vertebrates (By similarity). {ECO:0000250|UniProtKB:P13183, ECO:0000250|UniProtKB:P24311}.
uniprot
proteins
mass_dalton
8995
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P13183}.
uniprot
proteins
protein_family
Cytochrome c oxidase VIIb family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7601105
uniprot
proteins
sequence_length
80
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P13183}; Single-pass membrane protein {ECO:0000250|UniProtKB:P13183}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..59; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P13183
uniprot
proteins