ARK2C
entrez
494470
canonical
uniprot
Q6ZSG1
canonical
ensembl
ENSG00000141622
resolver
ensp
ENSP00000269439
resolver
ensp
ENSP00000444285
resolver
ensp
ENSP00000626408
resolver
genesymbol
ARK2C
resolver
genesymbol
ARKL2
resolver
genesymbol_syn
RNF165
resolver
hgnc
HGNC:31696
resolver
uniprot
A0A059NXK6
resolver
uniprot
B3KVD1
resolver
uniprot_entry
A0A059NXK6_HUMAN
resolver
uniprot_entry
ARK2C_HUMAN
resolver
uniprot_sec
B3KVD1
resolver
activity_regulation
ACTIVITY REGULATION: Binds free ubiquitin non-covalently via its RING-type zinc finger. Ubiquitin-binding leads to enhance the E3 ubiquitin-protein ligase activity by stabilizing the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the 'closed' conformation and activating ubiquitin transfer (PubMed:26656854).
uniprot
proteins
amino_acid_sequence
MVLVHVGYLVLPVFGSVRNRGAPFQRSQHPHATSCRHFHLGPPQPQQLAPDFPLAHPVQSQPGLSAHMAPAHQHSGALHQSLTPLPTLQFQDVTGPSFLPQALHQQYLLQQQLLEAQHRRLVSHPRRSQERVSVHPHRLHPSFDFGQLQTPQPRYLAEGTDWDLSVDAGLSPAQFQVRPIPQHYQHYLATPRMHHFPRNSSSTQMVVHEIRNYPYPQLHFLALQGLNPSRHTSAVRESYEELLQLEDRLGNVTRGAVQNTIERFTFPHKYKKRRPQDGKGKKDEGEESDTDEKCTICLSMLEDGEDVRRLPCMHLFHQLCVDQWLAMSKKCPICRVDIETQLGADS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. {ECO:0000250|UniProtKB:E9QAU8}.
uniprot
proteins
mass_dalton
39526
uniprot
proteins
mutagenesis
MUTAGEN 309; /note="R->A: Reduced binding to free ubiquitin."; /evidence="ECO:0000269|PubMed:26656854"; MUTAGEN 313; /note="M->A: Reduced binding to free ubiquitin and reduced E3 ubiquitin-protein ligase activity."; /evidence="ECO:0000269|PubMed:26656854"; MUTAGEN 335; /note="R->A: Reduced ubiquitin discharge."; /evidence="ECO:0000269|PubMed:26656854
uniprot
proteins
protein_family
Arkadia family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
26656854
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:E9QAU8}.
uniprot
proteins