Lime1
entrez
72699
canonical
uniprot
Q9EQR5
canonical
ensembl
ENSMUSG00000090077
resolver
ensp
ENSMUSP00000045010
resolver
enst
ENSMUST00000048077
resolver
genesymbol
Lime1
resolver
genesymbol_syn
Lime
resolver
uniprot_entry
LIME1_MOUSE
resolver
amino_acid_sequence
MRPPVPSAPLALWVLGCFSLLLWLWALCTACHRKRAQRQQTGLQDSLVPVEMPLLRQTHLCSLSKSDTRLHELHRGPRSSIAPRPASMDLLHPRWLEMSRGSTRSQVPNSAFPPRQLPRAPPAAPATAPSTSSEATYSNVGLAAIPRASLAASPVVWAGTQLTISCARLGPGAEYACIQKHKGTEQGCQELQQKAKVIPATQMDVLYSRVCKPKRRDPRPVTDQLNLQDGRTSLPLGSDVEYEAINLRGQDMKQGPLENVYESIKEMGL
uniprot
proteins
function
FUNCTION: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:14610044, ECO:0000269|PubMed:16249387}.
uniprot
proteins
mass_dalton
29551
uniprot
proteins
mutagenesis
MUTAGEN 28; /note="C->S: Abolishes palmitoylation and lipid raft localization; when associated with S-31."; /evidence="ECO:0000269|PubMed:14610044"; MUTAGEN 31; /note="C->S: Abolishes palmitoylation and lipid raft localization; when associated with S-28."; /evidence="ECO:0000269|PubMed:14610044"; MUTAGEN 137; /note="Y->F: Reduces GRB2 binding."; /evidence="ECO:0000269|PubMed:16249387"; MUTAGEN 242; /note="Y->F: Abolishes LCK, PIK3R1 and LYN binding; when associated with F-261."; /evidence="ECO:0000269|PubMed:14610044, ECO:0000269|PubMed:16249387"; MUTAGEN 261; /note="Y->F: Strongly reduces PLCG2 binding. Abolishes LCK, PIK3R1 and LYN binding; when associated with F-242."; /evidence="ECO:0000269|PubMed:14610044, ECO:0000269|PubMed:16249387
uniprot
proteins
post_translational_modification
PTM: Palmitoylation of Cys-28 and Cys-31 is required for raft targeting. {ECO:0000269|PubMed:14610044}.; PTM: Phosphorylated on tyrosines upon TCR activation and/or CD4 coreceptor stimulation, or upon BCR stimulation; which leads to the recruitment of SH2-containing proteins. {ECO:0000269|PubMed:14610044, ECO:0000269|PubMed:16249387}.
uniprot
proteins
pubmed
14610044
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16249387
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14610044}; Single-pass type III membrane protein {ECO:0000269|PubMed:14610044}. Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins