Cmtm6
entrez
67213
canonical
uniprot
Q9CZ69
canonical
ensembl
ENSMUSG00000032434
resolver
ensp
ENSMUSP00000035007
resolver
ensp
ENSMUSP00000281822
resolver
enst
ENSMUST00000035007
resolver
genesymbol
Cmtm6
resolver
genesymbol_syn
Cklfsf6
resolver
uniprot
Q3U7C3
resolver
uniprot
Q922J1
resolver
uniprot_entry
CKLF6_MOUSE
resolver
uniprot_sec
Q3U7C3
resolver
uniprot_sec
Q922J1
resolver
amino_acid_sequence
MENGAVYSPTTEAAPGTGRGARSGLAAYFVLGRLPWHRRILKGLQLLLSLLAFICEEVVSECGLCGGLYFFEFVSCSAFLLSLLLLIVYCTPVHDRVDTGKVKSSDFYITLGTGCVFLLASIIFVSTHSGTSAEIAAIVFGFLASSMFLLDFVVMLCEKLRESPLRKPENNAKVEALTEPLNA
uniprot
proteins
function
FUNCTION: Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. {ECO:0000250|UniProtKB:Q9NX76}.
uniprot
proteins
mass_dalton
19824
uniprot
proteins
protein_family
Chemokine-like factor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NX76}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q9NX76}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9NX76}. Note=Co-localizes with PD-L1/CD274 in the plasma membrane and in recycling endosomes. {ECO:0000250|UniProtKB:Q9NX76}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..66; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 68..88; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 107..127; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 135..155; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins