Tmc2
entrez
192140
canonical
uniprot
Q8R4P4
canonical
ensembl
ENSMUSG00000060332
resolver
ensp
ENSMUSP00000077139
resolver
ensp
ENSMUSP00000125843
resolver
enst
ENSMUST00000077988
resolver
enst
ENSMUST00000166774
resolver
genesymbol
Tmc2
resolver
uniprot
Q7TQB1
resolver
uniprot_entry
TMC2_MOUSE
resolver
uniprot_sec
Q7TQB1
resolver
amino_acid_sequence
MSPQLKSLDEEGDKSARRPTRKQTSRAACPQDGHRAQSSRKDPAKGSPRPGSSRKKQMEHGSYHKGLQGQKPRKVERSLQGRKKDRRTSLKEQRASPKKEREALRKEAGKQLRKPRSTSLGSSVSTGDSLSEEELAQILEQVEEKKKLITTVRNKPWPMAKKLRELREAQAFVEKYEGALGKGKGKHLYAYRMMMAKKWVKFKRDFDNFKTQCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEERAMDFSVLWDFEGYIKYSALFYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLMIVIRSMASNTQGSTSEGDSDSFTFSFKMFTSWDYLIGNSETADNKYVSITTSFKESIVDEQESNKEGNIHLTRFLRVLANFLILCCLCGSGYLIYFVVKRSQEFSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYHPRTGLKWQLGRIFALFLGNLYTFLLALMDDVHLKLSNEEKIKNITHWTLFNYYNSSGGNESVPRPPPHPADVPRGSCWETAVGIEFMRLTVSDMLVTYLTILVGDFLRACFVRFMNHCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTVMSLPPSFDCGPFSGKNRMYDVLHETIENDFPKFLGKIFAFLANPGLIIPAILLMFLAIYYLNSVSKSLSRANAQLRKKIQALREVEKNHKSIKGKAIVTYSEDTIKNSSKNATQIHLTKEEPTSHSSSQIQTLDKKAQGPHTSSTEGGASPSTSWHHVGSQPPRGRRDSGQPQSQTYTGRSPSGKRTQRPHN
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system (PubMed:11850618, PubMed:23871232). The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, the tip-link PCDH15, and possibly the PIEZO subunits (By similarity). MET channel is activated by tension in the tip-link extending from the side wall of one stereocilium to the tip of the adjacent shorter stereocilium, where the channel is located (By similarity). TMC2 MET channel is highly permeable to calcium and likely transports monovalent cations (PubMed:23871232). Also involved in vestibular hair cell transduction current of the mammalian inner ear (PubMed:23871232). {ECO:0000250|UniProtKB:Q8R4P5, ECO:0000269|PubMed:11850618, ECO:0000269|PubMed:23871232}.
uniprot
proteins
mass_dalton
101134
uniprot
proteins
protein_family
TMC family
uniprot
proteins
pubmed
11850618
uniprot
proteins
pubmed
12812529
uniprot
proteins
pubmed
23871232
uniprot
proteins
pubmed
25114259
uniprot
proteins
pubmed
28504928
uniprot
proteins
pubmed
28663585
uniprot
proteins
pubmed
30138589
uniprot
proteins
pubmed
38228630
uniprot
proteins
sequence_length
888
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:E7FFT2}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the stereocilia tips of the cochlear hair cells and plasma membranes of cuticular plates. {ECO:0000269|PubMed:28504928, ECO:0000269|PubMed:38228630}.
uniprot
proteins
transmembrane_region
TRANSMEM 229..266; /note="Helical"; /evidence="ECO:0000250|UniProtKB:D3KZG3"; TRANSMEM 318..350; /note="Helical"; /evidence="ECO:0000250|UniProtKB:D3KZG3"; TRANSMEM 407..437; /note="Helical"; /evidence="ECO:0000250|UniProtKB:D3KZG3"; TRANSMEM 448..475; /note="Helical"; /evidence="ECO:0000250|UniProtKB:D3KZG3"; TRANSMEM 480..514; /note="Helical"; /evidence="ECO:0000250|UniProtKB:D3KZG3"; TRANSMEM 557..594; /note="Helical"; /evidence="ECO:0000250|UniProtKB:D3KZG3"; TRANSMEM 614..634; /note="Helical"; /evidence="ECO:0000250|UniProtKB:D3KZG3"; TRANSMEM 638..660; /note="Helical"; /evidence="ECO:0000250|UniProtKB:D3KZG3"; TRANSMEM 675..698; /note="Helical"; /evidence="ECO:0000250|UniProtKB:D3KZG3"; TRANSMEM 742..775; /note="Helical"; /evidence="ECO:0000250|UniProtKB:D3KZG3
uniprot
proteins