CD3G
entrez
917
canonical
uniprot
P09693
canonical
ensembl
ENSG00000160654
resolver
ensp
ENSP00000431445
resolver
ensp
ENSP00000571876
resolver
ensp
ENSP00000625661
resolver
enst
ENST00000532917
resolver
enst
ENST00000901817
resolver
enst
ENST00000955602
resolver
genesymbol
CD3G
resolver
genesymbol_syn
T3G
resolver
hgnc
HGNC:1675
resolver
uniprot
B0YIY5
resolver
uniprot
Q2HIZ6
resolver
uniprot_entry
B0YIY5_HUMAN
resolver
uniprot_entry
CD3G_HUMAN
resolver
uniprot_sec
Q2HIZ6
resolver
amino_acid_sequence
MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 17 (IMD17) [MIM:615607]: An autosomal recessive primary immunodeficiency characterized by highly variable clinical severity. Some patients have onset of severe recurrent infections in early infancy that may be lethal, whereas others may be only mildly affected or essentially asymptomatic into young adulthood. More severely affected patients may have evidence of autoimmune disease or enteropathy. The immunologic pattern is similar among patients, showing partial T-cell lymphopenia, decreased amounts of the CD3 complex, and impaired proliferative responses to T-cell receptor dependent stimuli. The phenotype in some patients is reminiscent of severe combined immunodeficiency. {ECO:0000269|PubMed:1635567, ECO:0000269|PubMed:17277165}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface (PubMed:8187769). Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G. {ECO:0000269|PubMed:2470098, ECO:0000269|PubMed:8187769, ECO:0000269|PubMed:8636209}.
uniprot
proteins
mass_dalton
20469
uniprot
proteins
mutagenesis
MUTAGEN 153; /note="L->A: Abolishes lysosomal targeting."; /evidence="ECO:0000269|PubMed:1535555, ECO:0000269|PubMed:8187769"; MUTAGEN 153; /note="L->I: Diminished but persistent lysosomal targeting."; /evidence="ECO:0000269|PubMed:1535555"; MUTAGEN 154; /note="L->A: Abolishes lysosomal targeting."; /evidence="ECO:0000269|PubMed:8187769"; MUTAGEN 154; /note="L->A: Diminished but persistent lysosomal targeting."; /evidence="ECO:0000269|PubMed:1535555"; MUTAGEN 154; /note="L->I: No effect."; /evidence="ECO:0000269|PubMed:1535555"; MUTAGEN 160; /note="Y->A: Abolishes lysosomal targeting."; /evidence="ECO:0000269|PubMed:1535555"; MUTAGEN 163; /note="L->A: Abolishes lysosomal targeting."; /evidence="ECO:0000269|PubMed:1535555
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8 (PubMed:2470098). Phosphorylated also by PKC; leading to the TCR complex down-regulation (PubMed:8187769). {ECO:0000269|PubMed:2470098, ECO:0000269|PubMed:8187769}.; PTM: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. {ECO:0000250|UniProtKB:P04234}.
uniprot
proteins
pubmed
14995914
uniprot
proteins
pubmed
15136729
uniprot
proteins
pubmed
1535555
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1635567
uniprot
proteins
pubmed
17277165
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
2470098
uniprot
proteins
pubmed
2540970
uniprot
proteins
pubmed
2826124
uniprot
proteins
pubmed
2944745
uniprot
proteins
pubmed
3112151
uniprot
proteins
pubmed
8187769
uniprot
proteins
pubmed
8636209
uniprot
proteins
sequence_length
182
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8636209}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins