Snai2
entrez
25554
canonical
uniprot
O08954
canonical
ensembl
ENSRNOG00000047699
resolver
ensembl
ENSRNOG00055003682
resolver
ensembl
ENSRNOG00060002886
resolver
ensembl
ENSRNOG00065007744
resolver
ensp
ENSRNOP00000064195
resolver
ensp
ENSRNOP00055004348
resolver
ensp
ENSRNOP00060003340
resolver
ensp
ENSRNOP00065008841
resolver
enst
ENSRNOT00000073049
resolver
enst
ENSRNOT00055005784
resolver
enst
ENSRNOT00060004669
resolver
enst
ENSRNOT00065012111
resolver
genesymbol
Snai2
resolver
genesymbol_syn
Slug
resolver
genesymbol_syn
Slugh
resolver
uniprot
Q8R482
resolver
uniprot_entry
SNAI2_RAT
resolver
uniprot_sec
Q8R482
resolver
amino_acid_sequence
MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLCESYPMPVIPKPEILTSGAYSPITVWTSAVPFHSPLPSGLSPLTGYSSSLGRVSPLPSSDTSSKDHSGSESPISDEEERLQPKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQARKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH
uniprot
proteins
function
FUNCTION: Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity). {ECO:0000250|UniProtKB:O43623, ECO:0000269|PubMed:16924233}.
uniprot
proteins
mass_dalton
29936
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for ubiquitination. {ECO:0000250|UniProtKB:O43623}.; PTM: Ubiquitinated by the SCF(FBXO11) complex; ubiquitination requires previous GSK3B-mediated SNAI2 phosphorylation. {ECO:0000250|UniProtKB:O43623}.
uniprot
proteins
protein_family
Snail C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
16924233
uniprot
proteins
pubmed
9182671
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43623}. Cytoplasm {ECO:0000250|UniProtKB:O43623}. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions (By similarity). {ECO:0000250|UniProtKB:O43623}.
uniprot
proteins