C1d
entrez
57316
canonical
uniprot
O35473
canonical
ensembl
ENSMUSG00000000581
resolver
ensp
ENSMUSP00000000594
resolver
ensp
ENSMUSP00000121134
resolver
enst
ENSMUST00000000594
resolver
genesymbol
C1d
resolver
genesymbol_syn
Suncor
resolver
uniprot
Q5SWJ6
resolver
uniprot
Q61368
resolver
uniprot_entry
C1D_MOUSE
resolver
uniprot_sec
Q5SWJ6
resolver
uniprot_sec
Q61368
resolver
amino_acid_sequence
MAGEEMNEDYPVEIHESLTALESSLGAVDDMLKTMMAVSRNELLQKLDPLEQAKVDLVSAYTLNSMFWVYLATQGVNPKEHPVKQELERIRVYMNRVKEITDKKKAAKLDRGAASRFVKNALWEPKAKSTPKVANKGKSKH
uniprot
proteins
function
FUNCTION: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). {ECO:0000250|UniProtKB:Q13901, ECO:0000269|PubMed:10362552, ECO:0000269|PubMed:9405624}.
uniprot
proteins
mass_dalton
15945
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKDC. {ECO:0000250}.
uniprot
proteins
protein_family
C1D family
uniprot
proteins
pubmed
10362552
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9405624
uniprot
proteins
pubmed
9469821
uniprot
proteins
sequence_length
141
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9405624}. Cytoplasm {ECO:0000250|UniProtKB:Q13901}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q13901}. Note=EXOSC10 is required for nucleolar localization. Colocalizes with TSNAX in the nucleus. {ECO:0000250|UniProtKB:Q13901}.
uniprot
proteins