TRIM23
entrez
373
canonical
uniprot
P36406
canonical
ensembl
ENSG00000113595
resolver
ensp
ENSP00000231524
resolver
ensp
ENSP00000274327
resolver
ensp
ENSP00000370406
resolver
genesymbol
TRIM23
resolver
genesymbol_syn
ARD1
resolver
genesymbol_syn
ARFD1
resolver
genesymbol_syn
RNF46
resolver
hgnc
HGNC:660
resolver
uniprot
Q9BZY4
resolver
uniprot
Q9BZY5
resolver
uniprot_entry
TRI23_HUMAN
resolver
uniprot_sec
Q9BZY4
resolver
uniprot_sec
Q9BZY5
resolver
amino_acid_sequence
MATLVVNKLGAGVDSGRQGSRGTAVVKVLECGVCEDVFSLQGDKVPRLLLCGHTVCHDCLTRLPLHGRAIRCPFDRQVTDLGDSGVWGLKKNFALLELLERLQNGPIGQYGAAEESIGISGESIIRCDEDEAHLASVYCTVCATHLCSECSQVTHSTKTLAKHRRVPLADKPHEKTMCSQHQVHAIEFVCLEEGCQTSPLMCCVCKEYGKHQGHKHSVLEPEANQIRASILDMAHCIRTFTEEISDYSRKLVGIVQHIEGGEQIVEDGIGMAHTEHVPGTAENARSCIRAYFYDLHETLCRQEEMALSVVDAHVREKLIWLRQQQEDMTILLSEVSAACLHCEKTLQQDDCRVVLAKQEITRLLETLQKQQQQFTEVADHIQLDASIPVTFTKDNRVHIGPKMEIRVVTLGLDGAGKTTILFKLKQDEFMQPIPTIGFNVETVEYKNLKFTIWDVGGKHKLRPLWKHYYLNTQAVVFVVDSSHRDRISEAHSELAKLLTEKELRDALLLIFANKQDVAGALSVEEITELLSLHKLCCGRSWYIQGCDARSGMGLYEGLDWLSRQLVAAGVLDVA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that harbors GTPase activity encoded by the C-terminal ARF domain. Plays an essential role in autophagy activation during viral infection (PubMed:31189704, PubMed:40360474). Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1 (PubMed:28871090, PubMed:31189704). In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090). Catalyzes 'Lys-63'-linked polyubiquitination of HAX1 that triggers its liquid-liquid phase separation (LLPS) and contributes to P-bodies assembly induced by energy stress (PubMed:38769438). {ECO:0000269|PubMed:15684077, ECO:0000269|PubMed:28871090, ECO:0000269|PubMed:31189704, ECO:0000269|PubMed:38769438, ECO:0000269|PubMed:40360474}.; FUNCTION: (Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection. {ECO:0000269|PubMed:15684077}.
uniprot
proteins
mass_dalton
64067
uniprot
proteins
mutagenesis
MUTAGEN 34; /note="C->A: Loss of E3 ubiquitin-protein ligase activity."; /evidence="ECO:0000269|PubMed:15684077"; MUTAGEN 39; /note="S->A: Exhibits a near-complete loss of 'Lys-27'-linked ubiquitination."; /evidence="ECO:0000269|PubMed:40360474"; MUTAGEN 39; /note="S->D: No loss of 'Lys-27'-linked ubiquitination."; /evidence="ECO:0000269|PubMed:40360474"; MUTAGEN 53; /note="H->A: Loss of E3 ubiquitin-protein ligase activity."; /evidence="ECO:0000269|PubMed:15684077"; MUTAGEN 418; /note="T->N: Maintains GTPase activity. Increases interaction with PSCD1."; /evidence="ECO:0000269|PubMed:10748148"; MUTAGEN 458; /note="K->I: Suppresses GTPase activity. Decreases interaction with PSCD1."; /evidence="ECO:0000269|PubMed:10748148
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:38769438}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-39 triggers TRIM23 autoubiquitination and GTPase activity. {ECO:0000269|PubMed:40360474}.; PTM: Auto-ubiquitinated. {ECO:0000269|PubMed:40360474}.
uniprot
proteins
protein_family
Arf family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10748148
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15684077
uniprot
proteins
pubmed
19176615
uniprot
proteins
pubmed
28681414
uniprot
proteins
pubmed
28871090
uniprot
proteins
pubmed
31189704
uniprot
proteins
pubmed
38769438
uniprot
proteins
pubmed
40360474
uniprot
proteins
pubmed
8473324
uniprot
proteins
pubmed
9671726
uniprot
proteins
sequence_length
574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28871090, ECO:0000269|PubMed:38769438}. Endomembrane system {ECO:0000269|PubMed:9671726}. Golgi apparatus membrane {ECO:0000269|PubMed:9671726}. Lysosome membrane {ECO:0000269|PubMed:9671726}. Cytoplasm, P-body {ECO:0000269|PubMed:38769438}. Note=Membrane-associated with the Golgi complex and lysosomal structures.
uniprot
proteins