RWDD3
entrez
25950
canonical
uniprot
Q9Y3V2
canonical
ensembl
ENSG00000122481
resolver
ensp
ENSP00000263893
resolver
ensp
ENSP00000359221
resolver
ensp
ENSP00000650084
resolver
genesymbol
RWDD3
resolver
genesymbol_syn
RSUME
resolver
hgnc
HGNC:21393
resolver
uniprot
A6NP44
resolver
uniprot
A8K9F0
resolver
uniprot
C9J9L7
resolver
uniprot
C9JI45
resolver
uniprot
Q08AJ7
resolver
uniprot
Q6FID3
resolver
uniprot
Q9BX35
resolver
uniprot_entry
RWDD3_HUMAN
resolver
uniprot_sec
A6NP44
resolver
uniprot_sec
A8K9F0
resolver
uniprot_sec
C9J9L7
resolver
uniprot_sec
C9JI45
resolver
uniprot_sec
Q08AJ7
resolver
uniprot_sec
Q6FID3
resolver
uniprot_sec
Q9BX35
resolver
amino_acid_sequence
MAEPVQEELSVLAAIFCRPHEWEVLSRSETDGTVFRIHTKAEGFMDVDIPLELVFHLPVNYPSCLPGISINSEQLTRAQCVTVKENLLEQAESLLSEPMVHELVLWIQQNLRHILSQPETGSGSEKCTFSTSTTMDDGLWITLLHLDHMRAKTKYVKIVEKWASDLRLTGRLMFMGKIILILLQGDRNNLKEYLILQKTSKVDVDSSGKKCKEKMISVLFETKVQTEHKRFLAFEVKEYSALDELQKEFETAGLKKLFSEFVLALVK
uniprot
proteins
function
FUNCTION: Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination. {ECO:0000269|PubMed:17956732, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:23469069, ECO:0000269|PubMed:23508108}.
uniprot
proteins
mass_dalton
30543
uniprot
proteins
mutagenesis
MUTAGEN 61..62; /note="YP->AA: Abolishes enhancement of NFKBIA and NR3C1 sumoylation. No effect on NR3C1 transcriptional activity."; /evidence="ECO:0000269|PubMed:17956732, ECO:0000269|PubMed:23508108
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17956732
uniprot
proteins
pubmed
22009797
uniprot
proteins
pubmed
23469069
uniprot
proteins
pubmed
23508108
uniprot
proteins
pubmed
25918163
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17956732}. Cytoplasm {ECO:0000269|PubMed:17956732}. Note=Colocalizes with UBC9/UBE2I in nuclear spots. {ECO:0000269|PubMed:17956732}.
uniprot
proteins