Macroh2a2
entrez
404634
canonical
uniprot
Q8CCK0
canonical
ensembl
ENSMUSG00000020086
resolver
ensp
ENSMUSP00000020283
resolver
ensp
ENSMUSP00000215285
resolver
enst
ENSMUST00000020283
resolver
genesymbol
Macroh2a2
resolver
genesymbol_syn
H2afy2
resolver
genesymbol_syn
H2afy3
resolver
uniprot
A0JP36
resolver
uniprot
Q3TNT4
resolver
uniprot
Q925I6
resolver
uniprot_entry
H2AW_MOUSE
resolver
uniprot_sec
A0JP36
resolver
uniprot_sec
Q3TNT4
resolver
uniprot_sec
Q925I6
resolver
amino_acid_sequence
MSGRSGKKKMSKLSRSARAGVIFPVGRLMRYLKKGTFKYRISVGAPVYMAAVIEYLAAEILELAGNAARDNKKARIAPRHILLAVANDEELNQLLKGVTIASGGVLPRIHPELLAKKRGTKGKSETILSPPPEKRGRKAASGKKGGKKSKATKPRTSKKSKAKDSDKEGTSNSTSEDGPGDGFTILSSKSLVLGQKLSLTQSDISHIGSMRVEGIVHPTTAEIDLKEEIGKALEKAGGKEFLETVKELRKSQGPLEVAEAAVSQSSGLAAKFVIHCHIPQWGSDKCEEQLEETIKNCLSAAEDKKLKSVAFPPFPSGRNCFPKQTAAQVTLKAISAHFDDSSSSSLKNVYFLLFDSESIGIYVQEMAKLDTK
uniprot
proteins
function
FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
uniprot
proteins
mass_dalton
40092
uniprot
proteins
pubmed
11262398
uniprot
proteins
pubmed
11331621
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11262398}. Chromosome {ECO:0000269|PubMed:11262398}. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.
uniprot
proteins