CFAP61
entrez
26074
canonical
uniprot
Q8NHU2
canonical
ensembl
ENSG00000089101
resolver
ensp
ENSP00000245957
resolver
ensp
ENSP00000414537
resolver
genesymbol
CFAP61
resolver
genesymbol_syn
C20orf26
resolver
hgnc
HGNC:15872
resolver
uniprot
A6NHA1
resolver
uniprot
Q5JXV4
resolver
uniprot
Q5TE18
resolver
uniprot
Q8N5R9
resolver
uniprot
Q96M59
resolver
uniprot
Q9BQL2
resolver
uniprot
Q9H127
resolver
uniprot
Q9H128
resolver
uniprot
Q9NQH4
resolver
uniprot
Q9UFV8
resolver
uniprot
Q9Y4V7
resolver
uniprot_entry
CFA61_HUMAN
resolver
uniprot_sec
A6NHA1
resolver
uniprot_sec
Q5JXV4
resolver
uniprot_sec
Q5TE18
resolver
uniprot_sec
Q8N5R9
resolver
uniprot_sec
Q96M59
resolver
uniprot_sec
Q9BQL2
resolver
uniprot_sec
Q9H127
resolver
uniprot_sec
Q9H128
resolver
uniprot_sec
Q9NQH4
resolver
uniprot_sec
Q9UFV8
resolver
uniprot_sec
Q9Y4V7
resolver
amino_acid_sequence
MSVLTSPRGKVEVVHCRRTESQDVYCIKSLIRKFTCKLFGKLNIIYLLEKANLAVTLCNDKEEIMAQATFLDYPNWNVAKQDDWVSVFRELDSDIPCTPLNTLFMHLFVAVDEYSVGCCKEILRTVYKAVPELHFIFLIVPSYMSLGSTLITVFDQVGNIPCLTYEEDFAVHICHRHSHYPQLHVRKARVEDHDDLMPIFMRYDTILKETYGEYFLAELIEAQDEENHAVVCEVEGTAVGFMSVCSRVNMQLLHECFDLGPFHGLCFPHPDDVLESPQDLSVRRSQDAELRSSSQGSQKIVEELQEPVSPDTMENIQGNIAREAASEEALTAVQSGNVSEPEDIEKLSDISTGYAQYHHVSSRSLASLVLPEEPVHFRPIYRGASAAFCIQLFCIDEKYEARSLDFMNFVFSLFSDKNFCVISLPHLTPEFFLIQNFVKMVPFNTCTLEQDLYVFHRAGLLKSINIRFATLLDTPGVENLVSTLMLNKSILEDLDRYNKARKDPDGTLLQAFVAEVAEQIVGIAVIRNEMDIEYIRSHYNIEDFIYFSHHQREEHGHMHHFALNPIFRHYTKFFLKEILRLGFKSCLYYRVYPKSREGKFQNPYAHSLTSALHYLVPVRPRRQIVYPLEKLGINAPSKAVSKDPMSYALNHTNRKLTLEPKITVNAKIIVVGASSVGISFLETLVFCSHMKFNNLTLISTHGLPGKKLLDTEQRKFLASDHCFNDKDYALMSLCSWVNVVVGRMTGIDRAAKHVVLSTDEIVPYDHLILCTGQQYQVPCPTEADISQHLTNREVPNSSQRRYTGKVPCNHFTLNEEEDCFKALIWIRNNSITTEGNIIVYGNTIDTYTTVETLLNLGVSGSRIHLVQPPPASTITCINNYSVESAVADALGAAGVTMYRDAILAQWNDGLHPDPIYSASFTTPTKPFRLQCSMFFSFCEKNVDYETFKALNDACLVYDSRLVIDTNFHTNDIAIRAAGSLTKFSNRYYSNEWTHSNFSSKEIGFQLAAAMLHLFDPTLEPVTEPPANLDRLIPMYKGAKIQGGILPGSYHYLHIAKPAIPTPLEVQMAQPNYGLELVTGSAKNGTYFRIHINKYKMVETITCLSREPFPASNYIRLFGQHEQLLNNLCARYDENLITDLYSYFTEPWCLALFHDRFIDLRKELRQILASKEEEDLPSIEQLAHQIEDEEINPTEKPRQYLKRVFEESIYKTLVERSTLDYLHYNRYHLPMYAWPGIV
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 84 (SPGF84) [MIM:620409]: An autosomal recessive male infertility disorder characterized by multiple morphologic abnormalities of the sperm flagella, resulting in severely reduced motility. Some patients also have a reduced sperm count. {ECO:0000269|PubMed:34792097, ECO:0000269|PubMed:35174165, ECO:0000269|PubMed:35387802}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Involved in sperm flagellum assembly (PubMed:34792097, PubMed:35174165). Plays an essential role in the formation of the radial spokes in flagellum axoneme (By similarity). {ECO:0000250|UniProtKB:Q8CEL2, ECO:0000269|PubMed:34792097, ECO:0000269|PubMed:35174165}.
uniprot
proteins
mass_dalton
141349
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23033978
uniprot
proteins
pubmed
28282151
uniprot
proteins
pubmed
34792097
uniprot
proteins
pubmed
35174165
uniprot
proteins
pubmed
35387802
uniprot
proteins
sequence_length
1237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q8CEL2}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:28282151}. Cell projection, cilium {ECO:0000269|PubMed:28282151}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8CEL2}. Note=Localizes to the manchette in elongating spermatids in a CFAP70-dependent manner. {ECO:0000250|UniProtKB:Q8CEL2}.
uniprot
proteins