Sema6a
entrez
20358
canonical
uniprot
O35464
canonical
ensembl
ENSMUSG00000019647
resolver
ensp
ENSMUSP00000019791
resolver
ensp
ENSMUSP00000075420
resolver
ensp
ENSMUSP00000120011
resolver
enst
ENSMUST00000135790
resolver
genesymbol
Sema6a
resolver
genesymbol_syn
Semaq
resolver
uniprot
D3YWM8
resolver
uniprot
Q6P5A8
resolver
uniprot
Q6PCN9
resolver
uniprot
Q8BUT0
resolver
uniprot
Q8BXZ7
resolver
uniprot
Q9EQ71
resolver
uniprot_entry
D3YWM8_MOUSE
resolver
uniprot_entry
Q8BUT0_MOUSE
resolver
uniprot_entry
Q8BXZ7_MOUSE
resolver
uniprot_entry
SEM6A_MOUSE
resolver
uniprot_sec
Q6P5A8
resolver
uniprot_sec
Q6PCN9
resolver
uniprot_sec
Q9EQ71
resolver
amino_acid_sequence
MRPAALLLCLTLLHCAGAGFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIMIMNRTLYVAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDTLFVCGTNAFNPSCRNYRVDTLETFGDEFSGMARCPYDAKHANIALFADGKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRINGRDVVLATFSTPYNSIPGSAVCAYDMLDIANVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLEKYATSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRLTKIAVDNAAGPYQNHTVVFLGSEKGIILKFLARIGSSGFLNGSLFLEEMNVYNPEKCSYDGVEDKRIMGMQLDRASGSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWVRESGSCAHLSPLSRLTFEQDIERGNTDGLGDCHNSFVALNGHASSLYPSTTTSDSASRDGYESRGGMLDWNDLLEAPGSTDPLGAVSSHNHQDKKGVIRESYLKSNDQLVPVTLLAIAVILAFVMGAVFSGIIVYCVCDHRRKDVAVVQRKEKELTHSRRGSMSSVTKLSGLFGDTQSKDPKPEAILTPLMHNGKLATPSNTAKMLIKADQHHLDLTALPTPESTPTLQQKRKPNRGSREWERNQNIINACTKDMPPMGSPVIPTDLPLRASPSHIPSVVVLPITQQGYQHEYVDQPKMSEVVAQMALEDQAATLEYKTIKEHLSSKSPNHGVNLVENLDSLPPKVPQREASLGPPGTSLSQTGLSKRLEMQHSSSYGLEYKRSYPTNSLTRSHQTTTLKRNNTNSSNSSHLSRNQSFGRGDNPPPAPQRVDSIQVHSSQPSGQAVTVSRQPSLNAYNSLTRSGLKRTPSLKPDVPPKPSFAPLSTSMKPNDACT
uniprot
proteins
function
FUNCTION: Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. {ECO:0000269|PubMed:16205717, ECO:0000269|PubMed:19063725, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:20881961}.
uniprot
proteins
mass_dalton
114433
uniprot
proteins
mutagenesis
MUTAGEN 191; /note="L->R: Strongly reduced affinity for PLXNA2."; /evidence="ECO:0000269|PubMed:20877282"; MUTAGEN 212; /note="H->N: Strongly reduced affinity for PLXNA2."; /evidence="ECO:0000269|PubMed:20881961"; MUTAGEN 322; /note="I->E: Abolishes homodimerization."; /evidence="ECO:0000269|PubMed:20877282"; MUTAGEN 393; /note="K->E: Strongly reduced affinity for PLXNA2."; /evidence="ECO:0000269|PubMed:20881961"; MUTAGEN 415; /note="M->C: Formation of disulfide-linked homodimer."; /evidence="ECO:0000269|PubMed:20881961
uniprot
proteins
protein_family
Semaphorin family
uniprot
proteins
pubmed
10993894
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16205717
uniprot
proteins
pubmed
19063725
uniprot
proteins
pubmed
20877282
uniprot
proteins
pubmed
20881961
uniprot
proteins
pubmed
9204478
uniprot
proteins
sequence_length
1031
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20881961}; Single-pass type I membrane protein {ECO:0000269|PubMed:20881961}.
uniprot
proteins
transmembrane_region
TRANSMEM 650..670; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins