DDX54
entrez
79039
canonical
uniprot
Q8TDD1
canonical
ensembl
ENSG00000123064
resolver
ensp
ENSP00000304072
resolver
ensp
ENSP00000323858
resolver
genesymbol
DDX54
resolver
hgnc
HGNC:20084
resolver
uniprot
Q86YT8
resolver
uniprot
Q9BRZ1
resolver
uniprot_entry
DDX54_HUMAN
resolver
uniprot_sec
Q86YT8
resolver
uniprot_sec
Q9BRZ1
resolver
amino_acid_sequence
MAADKGPAAGPRSRAAMAQWRKKKGLRKRRGAASQARGSDSEDGEFEIQAEDDARARKLGPGRPLPTFPTSECTSDVEPDTREMVRAQNKKKKKSGGFQSMGLSYPVFKGIMKKGYKVPTPIQRKTIPVILDGKDVVAMARTGSGKTACFLLPMFERLKTHSAQTGARALILSPTRELALQTLKFTKELGKFTGLKTALILGGDRMEDQFAALHENPDIIIATPGRLVHVAVEMSLKLQSVEYVVFDEADRLFEMGFAEQLQEIIARLPGGHQTVLFSATLPKLLVEFARAGLTEPVLIRLDVDTKLNEQLKTSFFLVREDTKAAVLLHLLHNVVRPQDQTVVFVATKHHAEYLTELLTTQRVSCAHIYSALDPTARKINLAKFTLGKCSTLIVTDLAARGLDIPLLDNVINYSFPAKGKLFLHRVGRVARAGRSGTAYSLVAPDEIPYLLDLHLFLGRSLTLARPLKEPSGVAGVDGMLGRVPQSVVDEEDSGLQSTLEASLELRGLARVADNAQQQYVRSRPAPSPESIKRAKEMDLVGLGLHPLFSSRFEEEELQRLRLVDSIKNYRSRATIFEINASSRDLCSQVMRAKRQKDRKAIARFQQGQQGRQEQQEGPVGPAPSRPALQEKQPEKEEEEEAGESVEDIFSEVVGRKRQRSGPNRGAKRRREEARQRDQEFYIPYRPKDFDSERGLSISGEGGAFEQQAAGAVLDLMGDEAQNLTRGRQQLKWDRKKKRFVGQSGQEDKKKIKTESGRYISSSYKRDLYQKWKQKQKIDDRDSDEEGASDRRGPERRGGKRDRGQGASRPHAPGTPAGRVRPELKTKQQILKQRRRAQKLHFLQRGGLKQLSARNRRRVQELQQGAFGRGARSKKGKMRKRM
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Nucleolar RNA helicase that is involved in diverse cellular processes including ribosome biogenesis, DNA damage response, RNA splicing, transcriptional regulation, innate immunity, and nervous system development. Plays an essential role in the formation of the ribosome active site by remodeling rRNA structure and initiating peptidyl transferase center formation (PubMed:38632236). Represses the transcriptional activity of several nuclear receptors. Regulates transcriptome dynamics during DNA damage response. Mechanistically, acts via increased interaction with a well-defined class of pre-mRNAs that contain introns with weak acceptor splice sites, as well as by protein-protein contacts within components of U2 snRNP and spliceosomal B complex. These activities lead to reduced intron retention and enhanced processing rates of its target transcripts (PubMed:28596291). Acts as an inhibitor of type I interferon antiviral response by facilitating ALKBH5-mediated demethylation of specific transcripts (PubMed:40793791). Contributes to central nervous system myelination, likely through regulation of oligodendrocyte differentiation and myelin sheath formation (By similarity). {ECO:0000250|UniProtKB:Q8K4L0, ECO:0000269|PubMed:12466272, ECO:0000269|PubMed:28596291, ECO:0000269|PubMed:38632236, ECO:0000269|PubMed:40793791}.
uniprot
proteins
mass_dalton
98595
uniprot
proteins
mutagenesis
MUTAGEN 250; /note="D->A: Loss of ATPase activity."; /evidence="ECO:0000269|PubMed:40793791"; MUTAGEN 280; /note="T->G: No change in IFN-beta promoter down-regulation activity."; /evidence="ECO:0000269|PubMed:40793791"; MUTAGEN 401; /note="G->A: No change in IFN-beta promoter down- regulation activity."; /evidence="ECO:0000269|PubMed:40793791
uniprot
proteins
protein_family
DDX54/DBP10 subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
12466272
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28596291
uniprot
proteins
pubmed
31256877
uniprot
proteins
pubmed
38632236
uniprot
proteins
pubmed
40793791
uniprot
proteins
sequence_length
881
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:40793791}. Nucleus, nucleoplasm {ECO:0000269|PubMed:28596291, ECO:0000269|PubMed:40793791}. Note=Relocates from the nucleolus to the nucleoplasm upon viral infection. {ECO:0000269|PubMed:40793791}.
uniprot
proteins