ABHD2
entrez
11057
canonical
uniprot
P08910
canonical
ensembl
ENSG00000140526
resolver
ensp
ENSP00000268129
resolver
ensp
ENSP00000455639
resolver
ensp
ENSP00000535020
resolver
ensp
ENSP00000535021
resolver
ensp
ENSP00000535022
resolver
ensp
ENSP00000535023
resolver
ensp
ENSP00000535024
resolver
ensp
ENSP00000535025
resolver
ensp
ENSP00000535026
resolver
ensp
ENSP00000535027
resolver
ensp
ENSP00000535028
resolver
ensp
ENSP00000535029
resolver
ensp
ENSP00000535030
resolver
ensp
ENSP00000535031
resolver
ensp
ENSP00000535032
resolver
ensp
ENSP00000535033
resolver
ensp
ENSP00000535034
resolver
ensp
ENSP00000621648
resolver
ensp
ENSP00000621649
resolver
ensp
ENSP00000621650
resolver
ensp
ENSP00000621651
resolver
ensp
ENSP00000621652
resolver
ensp
ENSP00000621653
resolver
ensp
ENSP00000621654
resolver
enst
ENST00000352732
resolver
enst
ENST00000565973
resolver
enst
ENST00000864961
resolver
enst
ENST00000864962
resolver
enst
ENST00000864963
resolver
enst
ENST00000864964
resolver
enst
ENST00000864965
resolver
enst
ENST00000864966
resolver
enst
ENST00000864967
resolver
enst
ENST00000864968
resolver
enst
ENST00000864969
resolver
enst
ENST00000864970
resolver
enst
ENST00000864971
resolver
enst
ENST00000864972
resolver
enst
ENST00000864973
resolver
enst
ENST00000864974
resolver
enst
ENST00000864975
resolver
enst
ENST00000951589
resolver
enst
ENST00000951590
resolver
enst
ENST00000951591
resolver
enst
ENST00000951592
resolver
enst
ENST00000951594
resolver
enst
ENST00000951595
resolver
genesymbol
ABHD2
resolver
genesymbol_syn
LABH2
resolver
hgnc
HGNC:18717
resolver
uniprot
A0A024RC89
resolver
uniprot
Q53G48
resolver
uniprot
Q53GU0
resolver
uniprot
Q5FVD9
resolver
uniprot
Q8TC79
resolver
uniprot_entry
A0A024RC89_HUMAN
resolver
uniprot_entry
ABHD2_HUMAN
resolver
uniprot_sec
Q53G48
resolver
uniprot_sec
Q53GU0
resolver
uniprot_sec
Q5FVD9
resolver
uniprot_sec
Q8TC79
resolver
activity_regulation
ACTIVITY REGULATION: Acylglycerol lipase activity is activated upon binding to progesterone. {ECO:0000269|PubMed:26989199}.
uniprot
proteins
amino_acid_sequence
MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDITMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYANAICQWERNKLQCSDTEQVEADLE
uniprot
proteins
ec_number
3.1.1.23
uniprot
proteins
ec_number
3.1.1.6
uniprot
proteins
ec_number
3.1.1.79
uniprot
proteins
function
FUNCTION: Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester (PubMed:27247428). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity). {ECO:0000250|UniProtKB:Q9QXM0, ECO:0000269|PubMed:26989199, ECO:0000269|PubMed:27247428}.
uniprot
proteins
mass_dalton
48315
uniprot
proteins
protein_family
AB hydrolase 4 family
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26989199
uniprot
proteins
pubmed
27247428
uniprot
proteins
pubmed
2843827
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000305|PubMed:26989199}; Single-pass type II membrane protein {ECO:0000305}. Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins