DGKG
entrez
1608
canonical
uniprot
P49619
canonical
ensembl
ENSG00000058866
resolver
ensp
ENSP00000265022
resolver
ensp
ENSP00000339777
resolver
ensp
ENSP00000371599
resolver
genesymbol
DGKG
resolver
genesymbol_syn
DAGK3
resolver
hgnc
HGNC:2853
resolver
uniprot
B2RAH4
resolver
uniprot
Q2M1H4
resolver
uniprot
Q5FWG1
resolver
uniprot_entry
DGKG_HUMAN
resolver
uniprot_sec
B2RAH4
resolver
uniprot_sec
Q2M1H4
resolver
uniprot_sec
Q5FWG1
resolver
activity_regulation
ACTIVITY REGULATION: The activity is calcium-dependent (By similarity). Requires phosphatidylserine for maximal activity (PubMed:8034597). {ECO:0000250|UniProtKB:P49620, ECO:0000269|PubMed:8034597}.
uniprot
proteins
amino_acid_sequence
MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMRAYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEACAPDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD
uniprot
proteins
ec_number
2.7.1.107
uniprot
proteins
function
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity). Has no apparent specificity with regard to the acyl compositions of diacylglycerol (PubMed:8034597). Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity). {ECO:0000250|UniProtKB:Q91WG7, ECO:0000269|PubMed:8034597}.
uniprot
proteins
mass_dalton
89124
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000305|PubMed:8034597}.
uniprot
proteins
protein_family
Eukaryotic diacylglycerol kinase family
uniprot
proteins
pubmed
10071200
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
8034597
uniprot
proteins
sequence_length
791
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:8034597}. Cytoplasm, cytosol {ECO:0000269|PubMed:8034597}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P49620}.
uniprot
proteins