TMOD1
entrez
7111
canonical
uniprot
P28289
canonical
ensembl
ENSG00000136842
resolver
ensp
ENSP00000259365
resolver
ensp
ENSP00000364318
resolver
ensp
ENSP00000378637
resolver
genesymbol
TMOD1
resolver
genesymbol_syn
D9S57E
resolver
genesymbol_syn
TMOD
resolver
hgnc
HGNC:11871
resolver
uniprot
B2RB77
resolver
uniprot
Q5T7W3
resolver
uniprot
Q9BUF1
resolver
uniprot_entry
TMOD1_HUMAN
resolver
uniprot_sec
B2RB77
resolver
uniprot_sec
Q5T7W3
resolver
uniprot_sec
Q9BUF1
resolver
amino_acid_sequence
MSYRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALLPAGLRQKDQTTKAPTGPFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKVWVPKQKPLDPVLESVTLEPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALSSSSIMNKEGLNSVIKPTQYKPVPDEEPNSTDVEETLERIKNNDPKLEEVNLNNIRNIPIPTLKAYAEALKENSYVKKFSIVGTRSNDPVAYALAEMLKENKVLKTLNVESNFISGAGILRLVEALPYNTSLVEMKIDNQSQPLGNKVEMEIVSMLEKNATLLKFGYHFTQQGPRLRASNAMMNNNDLVRKRRLADLTGPIIPKCRSGV
uniprot
proteins
function
FUNCTION: Blocks the elongation and depolymerization of the actin filaments at the pointed end (PubMed:38168645). The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. {ECO:0000269|PubMed:38168645, ECO:0000269|PubMed:8002995}.
uniprot
proteins
mass_dalton
40569
uniprot
proteins
protein_family
Tropomodulin family
uniprot
proteins
pubmed
11054557
uniprot
proteins
pubmed
1370827
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25250574
uniprot
proteins
pubmed
38168645
uniprot
proteins
pubmed
8002995
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:25250574}. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574, PubMed:38168645). {ECO:0000269|PubMed:25250574, ECO:0000269|PubMed:38168645}.
uniprot
proteins