Ppp2cb
entrez
24673
canonical
uniprot
P62716
canonical
ensembl
ENSRNOG00000015182
resolver
ensembl
ENSRNOG00055012322
resolver
ensembl
ENSRNOG00060012066
resolver
ensembl
ENSRNOG00065002633
resolver
ensp
ENSRNOP00000020663
resolver
ensp
ENSRNOP00055016952
resolver
ensp
ENSRNOP00060016130
resolver
ensp
ENSRNOP00065002433
resolver
enst
ENSRNOT00000020663
resolver
enst
ENSRNOT00055020980
resolver
enst
ENSRNOT00060020475
resolver
enst
ENSRNOT00065003519
resolver
genesymbol
Ppp2cb
resolver
uniprot
P11082
resolver
uniprot
Q6LDK0
resolver
uniprot_entry
PP2AB_RAT
resolver
uniprot_sec
P11082
resolver
uniprot_sec
Q6LDK0
resolver
amino_acid_sequence
MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000250|UniProtKB:P62714}.
uniprot
proteins
mass_dalton
35575
uniprot
proteins
post_translational_modification
PTM: Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (Lcmt1) and protein phosphatase methylesterase 1 (Ppme1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization (By similarity). {ECO:0000250}.; PTM: Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation (By similarity). {ECO:0000250}.; PTM: May be monoubiquitinated by NOSIP. {ECO:0000250|UniProtKB:P62715}.
uniprot
proteins
protein_family
PP-1 subfamily
uniprot
proteins
protein_family
PPP phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2174876
uniprot
proteins
pubmed
2554256
uniprot
proteins
pubmed
2849437
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62714}. Nucleus {ECO:0000250|UniProtKB:P62714}. Chromosome, centromere {ECO:0000250|UniProtKB:P62714}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P62714}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. {ECO:0000250|UniProtKB:P62714}.
uniprot
proteins