Bpnt1
entrez
23827
canonical
uniprot
Q9Z0S1
canonical
ensembl
ENSMUSG00000026617
resolver
ensp
ENSMUSP00000027916
resolver
ensp
ENSMUSP00000106590
resolver
ensp
ENSMUSP00000147674
resolver
enst
ENSMUST00000027916
resolver
enst
ENSMUST00000110965
resolver
enst
ENSMUST00000210277
resolver
genesymbol
Bpnt1
resolver
uniprot
A0A1B0GRV0
resolver
uniprot
D3Z0E6
resolver
uniprot
Q3U8Z5
resolver
uniprot
Q91XB9
resolver
uniprot
Q9D7Y0
resolver
uniprot_entry
A0A1B0GRV0_MOUSE
resolver
uniprot_entry
BPNT1_MOUSE
resolver
uniprot_entry
D3Z0E6_MOUSE
resolver
uniprot_sec
Q3U8Z5
resolver
uniprot_sec
Q91XB9
resolver
uniprot_sec
Q9D7Y0
resolver
activity_regulation
ACTIVITY REGULATION: Uncompetitively inhibited by Li(+) (IC(50)=157 uM). PAP hydrolysis is competitively inhibited by PAPS (IC(50)=0.7 uM) and by inositol 1,4-bisphosphate (IC(50)=15 uM). {ECO:0000269|PubMed:10224133}.
uniprot
proteins
amino_acid_sequence
MASSHTVLMRLVASAYSIAQKAGTIVRCVIAEGDLGIVQKTSATDLQTKADRLVQMSICSSLARKFPKLTIIGEEDLPPGEVDQELIEDGQWEEILKQPCPSQYSAIKEEDLVVWVDPLDGTKEYTEGLLDNVTVLIGIAYEGKAIAGIINQPYYNYQAGPDAALGRTIWGVLGLGAFGFQLKEAPAGKHIITTTRSHSNQLVTDCISAMNPDTVLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILHAVGGKLTDIHGNALQYNKEVKHMNSAGVLAALRNYEYYASHVPESVKNALIP
uniprot
proteins
ec_number
3.1.3.57
uniprot
proteins
ec_number
3.1.3.7
uniprot
proteins
function
FUNCTION: Phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Is also able to hydrolyze inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), and is not active on Ins(1)P, Ins(4)P, Ins(3,4)P2, Ins(1,4,5)P3, Ins(1,3,4,5)P4, Ins(1,3,4,5,6)P5 or InsP6 (PubMed:10224133). Probably prevents the toxic accumulation of PAP, a compound which inhibits a variety of proteins, including PAPS-utilizing enzymes such as sulfotransferases, and RNA processing enzymes. Could also play a role in inositol recycling and phosphoinositide metabolism (By similarity). {ECO:0000250|UniProtKB:Q9Z1N4, ECO:0000269|PubMed:10224133}.
uniprot
proteins
mass_dalton
33196
uniprot
proteins
protein_family
Inositol monophosphatase superfamily
uniprot
proteins
pubmed
10224133
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
308
uniprot
proteins