Cyb561a3
entrez
225912
canonical
uniprot
Q6P1H1
canonical
ensembl
ENSMUSG00000034445
resolver
ensp
ENSMUSP00000130680
resolver
ensp
ENSMUSP00000157602
resolver
ensp
ENSMUSP00000157672
resolver
ensp
ENSMUSP00000157884
resolver
ensp
ENSMUSP00000157892
resolver
ensp
ENSMUSP00000158186
resolver
ensp
ENSMUSP00000172017
resolver
ensp
ENSMUSP00000172020
resolver
ensp
ENSMUSP00000172032
resolver
ensp
ENSMUSP00000172038
resolver
genesymbol
Cyb561a3
resolver
genesymbol_syn
Cybasc3
resolver
uniprot
Q3TVE2
resolver
uniprot
Q3V3G2
resolver
uniprot_entry
CYAC3_MOUSE
resolver
uniprot_sec
Q3TVE2
resolver
uniprot_sec
Q3V3G2
resolver
amino_acid_sequence
MASGWFYLSCMVLGSLGSMCILFTAYWMQYWRGGFAWDGTVLMFNWHPVLMVAGMVVLYGAASLVYRLPSSWVGPRLPWKVLHAALHLLAFTCTVVGLIAVFRFHNHSRIAHLYSLHSWLGITTVVLFACQWFLGFAVFLLPWASQWLRSLLKPLHVFFGACILSLSITSVISGINEKLFFVLKNATKPYSSLPGEAVFANSTGLLVVAFGLLVLYVLLASSWKRPDPGALTDRQPLLHDRE
uniprot
proteins
ec_number
7.2.1.3
uniprot
proteins
function
FUNCTION: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome (PubMed:16911521). Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters (Probable). It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis (Probable). {ECO:0000269|PubMed:16911521, ECO:0000305|PubMed:16911521}.
uniprot
proteins
mass_dalton
27086
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="D->A: No effect on transmembrane ascorbate ferrireductase activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 44; /note="F->A: Decreased transmembrane ascorbate ferrireductase activity. Approximately 45% reduction in enzyme activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 47; /note="H->A: Loss of transmembrane ascorbate ferrireductase activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 48; /note="P->A: No effect on transmembrane ascorbate ferrireductase activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 51; /note="M->A: No effect on transmembrane ascorbate ferrireductase activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 66; /note="Y->A: Loss of transmembrane ascorbate ferrireductase activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 67; /note="R->A: Loss of transmembrane ascorbate ferrireductase activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 83; /note="H->A: Loss of transmembrane ascorbate ferrireductase activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 105; /note="H->A: No effect on transmembrane ascorbate ferrireductase activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 106; /note="N->A: No effect on transmembrane ascorbate ferrireductase activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 112; /note="H->A: Decreased transmembrane ascorbate ferrireductase activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 115; /note="S->A: Decreased transmembrane ascorbate ferrireductase activity. Approximately 50% reduction in enzyme activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 117; /note="H->A: Loss of transmembrane ascorbate ferrireductase activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 118; /note="S->A: No effect on transmembrane ascorbate ferrireductase activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 119; /note="W->A: Decreased transmembrane ascorbate ferrireductase activity. Approximately 80% reduction in enzyme activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 131; /note="Q->A: Decreased transmembrane ascorbate ferrireductase activity. Approximately 55% reduction in enzyme activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 149; /note="R->A: Decreased transmembrane ascorbate ferrireductase activity. Approximately 75% reduction in enzyme activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 156; /note="H->A: Loss of transmembrane ascorbate ferrireductase activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 177; /note="E->A: No effect on transmembrane ascorbate ferrireductase activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 190; /note="Y->A: No effect on transmembrane ascorbate ferrireductase activity."; /evidence="ECO:0000269|PubMed:16911521"; MUTAGEN 196; /note="E->A: Decreased transmembrane ascorbate ferrireductase activity. Approximately 75% reduction in enzyme activity."; /evidence="ECO:0000269|PubMed:16911521
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:16996694}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16911521
uniprot
proteins
pubmed
16996694
uniprot
proteins
sequence_length
242
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:16996694}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}. Lysosome membrane {ECO:0000269|PubMed:16996694}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 41..61; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins