CPN1
entrez
1369
canonical
uniprot
P15169
canonical
ensembl
ENSG00000120054
resolver
ensp
ENSP00000359446
resolver
enst
ENST00000370418
resolver
genesymbol
CPN1
resolver
genesymbol_syn
ACBP
resolver
hgnc
HGNC:2312
resolver
uniprot
B1AP59
resolver
uniprot_entry
CBPN_HUMAN
resolver
uniprot_sec
B1AP59
resolver
amino_acid_sequence
MSDLLSVFLHLLLLFKLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINHDVTSGDHGDYFRLLLPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRSIPQVSPVRRAPSRRHGVRAKVQPQARKKEMEMRQLQRGPA
uniprot
proteins
disease_involvement
DISEASE: Carboxypeptidase N deficiency (CPND) [MIM:212070]: An autosomal recessive disorder characterized by angioedema, acute or chronic urticaria, and hay fever or asthma. Affected individuals have levels of carboxypeptidase N below the reference range. {ECO:0000269|PubMed:12560874}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.17.3
uniprot
proteins
function
FUNCTION: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
uniprot
proteins
mass_dalton
52286
uniprot
proteins
protein_family
Peptidase M14 family
uniprot
proteins
pubmed
12560874
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17157876
uniprot
proteins
pubmed
2912725
uniprot
proteins
pubmed
3408501
uniprot
proteins
pubmed
8267877
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space.
uniprot
proteins