Slc24a5
entrez
317750
canonical
uniprot
Q8C261
canonical
ensembl
ENSMUSG00000035183
resolver
ensp
ENSMUSP00000063887
resolver
enst
ENSMUST00000070353
resolver
genesymbol
Slc24a5
resolver
genesymbol_syn
Nckx5
resolver
uniprot
A2ATP8
resolver
uniprot
Q6XE39
resolver
uniprot
Q8CJF1
resolver
uniprot_entry
A2ATP8_MOUSE
resolver
uniprot_entry
NCKX5_MOUSE
resolver
uniprot_sec
Q6XE39
resolver
uniprot_sec
Q8CJF1
resolver
amino_acid_sequence
MRTKWGPTWTRRVLLLGIFWVSAYLPVRGVSLPPRLPRATGNSTQCAVSPASEFPEGFFTKQESTDGGIVIYFLIILYMCMAISIVCDKYFLPSLEIISDSLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNMVSTLSCWPLFRDCAVYAVSVGAVFGIIFDNRIYWYEGAGLLLIYGLYVLLLCFDTTISRHVMKTCSPCCPCLARAMEERIEQQTLLGWEDESQLFIRRQSRTDSGIFQEDSGYSQLSLSLHGLSQVSEDPPSVFSMPEADLRRIFWVLSLPIITLLALTTPDCRRKFWKNYFVITFFMSALWISAFTYILVWMVTVTGETLGIPDTVMGLTLLAAGTSIPDTVTSVLVARKGKGDMAISNIVGSNVFDMLCLGLPWFIKTAFTNASAPIEVNSKGLTYITISLNISILFLFLAVHFNGWKLDRKLGVVCLVLYLGLATLSVLYEIGIIGNNRIRGCGV
uniprot
proteins
function
FUNCTION: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes. {ECO:0000250|UniProtKB:Q71RS6}.
uniprot
proteins
mass_dalton
54984
uniprot
proteins
protein_family
Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family
uniprot
proteins
protein_family
SLC24A subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16357253
uniprot
proteins
pubmed
22677781
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q71RS6}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000250|UniProtKB:Q71RS6}.
uniprot
proteins
transmembrane_region
TRANSMEM 67..87; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 137..157; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 171..191; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 195..215; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 306..326; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 335..355; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 363..383; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 401..421; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 439..459; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 471..491; /note="Helical; Name=11"; /evidence="ECO:0000255
uniprot
proteins