Arid4b
entrez
84481
canonical
uniprot
Q9JKB5
canonical
ensembl
ENSRNOG00000016391
resolver
ensp
ENSRNOP00000010836
resolver
ensp
ENSRNOP00000069593
resolver
enst
ENSRNOT00000010836
resolver
enst
ENSRNOT00000078643
resolver
genesymbol
Arid4b
resolver
genesymbol_syn
Rbbp1l1
resolver
genesymbol_syn
Sap180
resolver
uniprot
A0A0G2JVS0
resolver
uniprot
F1LMH4
resolver
uniprot
F1LYA4
resolver
uniprot_entry
A0A0G2JVS0_RAT
resolver
uniprot_entry
ARI4B_RAT
resolver
uniprot_entry
F1LYA4_RAT
resolver
uniprot_sec
F1LMH4
resolver
amino_acid_sequence
MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEDDRKQTDELLGKVVCVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFDQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEIKVKEESDAEIKEVNVEDSKNMIPKEETPAEDESERKENIKPSLGSKKGLLECIPAQSDQEKEANITKLEEKESLEDKDGATARAEEALSTEVDAEEEQARSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDRDEKYSPKNCKLRRLSKSPFQSNPSPEMVSKLDLADAKNSDTGHIKSIEITSILNGLQASESSAEDSEQEEERCAQDPESSSKDESKVEHSAHSRSELISKEELSSPSLLEENKVHPDLVIAKTVSKSPERLRKDVEAISEDTDFEEEDEITKKRKDVKKDTTDKALKPQTKTWGKDRYCIQTNCLQSGSPGKKEDRTKSKEPLCTGNSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFSEVAEKRIKLLNNSDERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHAAPDEGTVEESLQTVAEEESCSPNMELEKPLPTSVDSKPVEEKPLEVSDRKTEFPSSGSNSVLNTPPTTPESPSSVTVTETSQQQSSVTVSVPLPPNQEEVRSIKSETDSTIEVDSVVGELQDLQSEGNSSPAGFNASVSSSSSNQPEPEHPEKACTGQKRVKDTQGVGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEDLSAGESVTKTQAIKSVPTGMKTHNSKSPARIQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERISILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR
uniprot
proteins
function
FUNCTION: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor. {ECO:0000250|UniProtKB:A2CG63, ECO:0000250|UniProtKB:Q4LE39}.
uniprot
proteins
mass_dalton
137080
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}.
uniprot
proteins