DNAJC2
entrez
27000
canonical
uniprot
Q99543
canonical
ensembl
ENSG00000105821
resolver
ensp
ENSP00000249270
resolver
ensp
ENSP00000368565
resolver
genesymbol
DNAJC2
resolver
genesymbol_syn
MPHOSPH11
resolver
genesymbol_syn
MPP11
resolver
genesymbol_syn
ZRF1
resolver
hgnc
HGNC:13192
resolver
uniprot
A4VCI0
resolver
uniprot
Q9BVX1
resolver
uniprot_entry
DNJC2_HUMAN
resolver
uniprot_sec
A4VCI0
resolver
uniprot_sec
Q9BVX1
resolver
amino_acid_sequence
MLLLPSAADGRGTAITHALTSASTLCQVEPVGRWFEAFVKRRNRNASASFQELEDKKELSEESEDEELQLEEFPMLKTLDPKDWKNQDHYAVLGLGHVRYKATQRQIKAAHKAMVLKHHPDKRKAAGEPIKEGDNDYFTCITKAYEMLSDPVKRRAFNSVDPTFDNSVPSKSEAKDNFFEVFTPVFERNSRWSNKKNVPKLGDMNSSFEDVDIFYSFWYNFDSWREFSYLDEEEKEKAECRDERRWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQRQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAERVKMMEEVEKLCDRLELASLQCLNETLTSCTKEVGKAALEKQIEEINEQIRKEKEEAEARMRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHGVVPQADNATPSERFEGPYTDFTPWTTEEQKLLEQALKTYPVNTPERWEKIAEAVPGRTKKDCMKRYKELVEMVKAKKAAQEQVLNASRAKK
uniprot
proteins
function
FUNCTION: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. {ECO:0000269|PubMed:15802566, ECO:0000269|PubMed:16002468, ECO:0000269|PubMed:21179169}.
uniprot
proteins
mass_dalton
71996
uniprot
proteins
mutagenesis
MUTAGEN 512..513; /note="HQ->AA: Loss of function."; /evidence="ECO:0000269|PubMed:15802566
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in M (mitotic) phase. {ECO:0000269|PubMed:8885239}.
uniprot
proteins
pubmed
11034098
uniprot
proteins
pubmed
12800198
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14696097
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15802566
uniprot
proteins
pubmed
16002468
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17242690
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20231810
uniprot
proteins
pubmed
21179169
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
8885239
uniprot
proteins
sequence_length
621
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21179169}. Cytoplasm, cytosol {ECO:0000269|PubMed:16002468, ECO:0000269|PubMed:21179169}.
uniprot
proteins