Hormad2
entrez
75828
canonical
uniprot
Q5SQP1
canonical
ensembl
ENSMUSG00000020419
resolver
ensp
ENSMUSP00000105574
resolver
ensp
ENSMUSP00000105575
resolver
ensp
ENSMUSP00000189403
resolver
ensp
ENSMUSP00000340034
resolver
ensp
ENSMUSP00000340035
resolver
genesymbol
Hormad2
resolver
uniprot
B7ZMW2
resolver
uniprot
Q9D507
resolver
uniprot_entry
HORM2_MOUSE
resolver
uniprot_sec
B7ZMW2
resolver
uniprot_sec
Q9D507
resolver
amino_acid_sequence
MATAQLSHNTRTLKASKNTIFPSQVTNEHESLVVVKKLFATCISCITYLRGLFPESSYRDRRLDDLSLKILREDKKCPGSLHIIKWIQGCFDALEKRYLHMAVLTLYTNPKEPEKVTEIYQFRFKYTKKGTTMDFDSSSTSFESGTDSEDIKKACSLLIRQLYILMQNLGPLPNDVILTMKLHYYNSVTPHDYQPPGFKEAVNSHFLLFEGEPVSLRMGSVSSGFHSMKVKVTTEATRMLDGENSVSQDDGTTEIAHQGLDCDEEEEACGSQVQRMNFVHIEPSFESSRKKKKVSEPVTVFIPNRK
uniprot
proteins
function
FUNCTION: Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation. {ECO:0000269|PubMed:22549958, ECO:0000269|PubMed:23039116}.
uniprot
proteins
mass_dalton
34812
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in a SPO11-dependent manner. {ECO:0000269|PubMed:22346761, ECO:0000269|PubMed:23039116}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19851446
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22346761
uniprot
proteins
pubmed
22549958
uniprot
proteins
pubmed
23039116
uniprot
proteins
sequence_length
306
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the male and female prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes.
uniprot
proteins