Mus81
entrez
293678
canonical
uniprot
Q4KM32
canonical
ensembl
ENSRNOG00000020617
resolver
ensembl
ENSRNOG00055021538
resolver
ensembl
ENSRNOG00060027137
resolver
ensembl
ENSRNOG00065033785
resolver
ensp
ENSRNOP00000028015
resolver
ensp
ENSRNOP00000090515
resolver
ensp
ENSRNOP00000095258
resolver
ensp
ENSRNOP00055029881
resolver
ensp
ENSRNOP00060039198
resolver
ensp
ENSRNOP00065047762
resolver
enst
ENSRNOT00000028015
resolver
enst
ENSRNOT00000093884
resolver
enst
ENSRNOT00000113189
resolver
enst
ENSRNOT00055036793
resolver
enst
ENSRNOT00060047123
resolver
enst
ENSRNOT00065058014
resolver
genesymbol
Mus81
resolver
uniprot
A0A8I6AEG6
resolver
uniprot
A0A8I6AMQ1
resolver
uniprot
A0A8L2QFD5
resolver
uniprot_entry
A0A8I6AEG6_RAT
resolver
uniprot_entry
A0A8I6AMQ1_RAT
resolver
uniprot_entry
A0A8L2QFD5_RAT
resolver
uniprot_entry
MUS81_RAT
resolver
amino_acid_sequence
MAEPVRLGRKRPLPVCPNPLFVRWLTEWRDEAASRGRHTRFVFQKALRSLQRYPLPLRNGKEAKILQHFGDRLCRMLDERLKEHLASGGDHAPSSPSGKKRASKGPPAQVQGSSMPVPTQPQAGSTNAGYWPAQNSGAREILLQLYREHLNSDGHSFLTKEELLQKCAQKTPRVVPESSRPWPALRGLLHRNLVLRTHRPARYALTPEGLELAQKLAEAEGLSTLNTAFQPEEHHEESPVPEAILSEPGTTEVGVQQRPLELRPSEYRVLLCVDIGETRGAGHRPEMLRELQRLRVPHTVRKLHVGDFVWVAQETRPRDPERPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLGHRIYLVEEHGSVQNLSLPESTLLQAVTNTQVIDGFFVKRTMDIKESAGYLALLTKGLERLYQGHTLHSRPWGTPGDAESEAKPSTNPLCSLLTFSDFNAEAVKNKAQSVREVFARQLMQVRGLSGEKAAALVDRYSTPASLLAAYDACATTKEQEMLLSTVKCGRLQRNLGPALSRTLYQLYCSHSPLT
uniprot
proteins
ec_number
3.1.22.-
uniprot
proteins
function
FUNCTION: Catalytic subunit of two functionally distinct, structure-specific, heterodimeric DNA endonucleases MUS81-EME1 and MUS81-EME2 that are involved in the maintenance of genome stability. Both endonucleases have essentially the same substrate specificity though MUS81-EME2 is more active than its MUS81-EME1 counterpart. Both cleave 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs. MUS81-EME2 which is active during the replication of DNA is more specifically involved in replication fork processing. Replication forks frequently encounter obstacles to their passage, including DNA base lesions, DNA interstrand cross-links, difficult-to-replicate sequences, transcription bubbles, or tightly bound proteins. One mechanism for the restart of a stalled replication fork involves nucleolytic cleavage mediated by the MUS81-EME2 endonuclease. By acting upon the stalled fork, MUS81-EME2 generates a DNA double-strand break (DSB) that can be repaired by homologous recombination, leading to the restoration of an active fork. MUS81-EME2 could also function in telomere maintenance. MUS81-EME1, on the other hand, is active later in the cell cycle and functions in the resolution of mitotic recombination intermediates including the Holliday junctions, the four-way DNA intermediates that form during homologous recombination. {ECO:0000250|UniProtKB:Q96NY9}.
uniprot
proteins
mass_dalton
61903
uniprot
proteins
protein_family
XPF family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
551
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q96NY9}. Note=Recruited to foci of DNA damage in S-phase cells. {ECO:0000250|UniProtKB:Q96NY9}.
uniprot
proteins