Cd8a
entrez
24930
canonical
uniprot
P07725
canonical
ensembl
ENSRNOG00000007178
resolver
ensembl
ENSRNOG00055020405
resolver
ensembl
ENSRNOG00060014674
resolver
ensembl
ENSRNOG00065005181
resolver
ensp
ENSRNOP00000106503
resolver
ensp
ENSRNOP00055028264
resolver
ensp
ENSRNOP00060019979
resolver
ensp
ENSRNOP00065005274
resolver
enst
ENSRNOT00000161718
resolver
enst
ENSRNOT00055034849
resolver
enst
ENSRNOT00060025082
resolver
enst
ENSRNOT00065007608
resolver
genesymbol
Cd8a
resolver
uniprot_entry
CD8A_RAT
resolver
amino_acid_sequence
MASRVICFLSLNLLLLDVITRLQVSGQLQLSPKKVDAEIGQEVKLTCEVLRDTSQGCSWLFRNSSSELLQPTFIIYVSSSRSKLNDILDPNLFSARKENNKYILTLSKFSTKNQGYYFCSITSNSVMYFSPLVPVFQKVNSIITKPVTRAPTPVPPPTGTPRPLRPEACRPGASGSVEGMGLGFACDIYIWAPLAGICAVLLLSLVITLICCHRNRRRVCKCPRPLVKPRPSEKFV
uniprot
proteins
function
FUNCTION: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. {ECO:0000250|UniProtKB:P01732}.
uniprot
proteins
mass_dalton
26196
uniprot
proteins
post_translational_modification
PTM: Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts. {ECO:0000250|UniProtKB:P01732}.; PTM: O-glycosylated. {ECO:0000250|UniProtKB:P01732}.; PTM: Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation. {ECO:0000250|UniProtKB:P01732}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1908233
uniprot
proteins
pubmed
3932064
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P01732}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P01732}. Note=CD8A localizes to lipid rafts only when associated with its partner CD8B. {ECO:0000250|UniProtKB:P01732}.
uniprot
proteins
transmembrane_region
TRANSMEM 190..210; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins