GADD45G
entrez
10912
canonical
uniprot
O95257
canonical
ensembl
ENSG00000130222
resolver
ensp
ENSP00000252506
resolver
ensp
ENSP00000649370
resolver
enst
ENST00000252506
resolver
genesymbol
GADD45G
resolver
genesymbol_syn
CR6
resolver
genesymbol_syn
DDIT2
resolver
hgnc
HGNC:4097
resolver
uniprot
Q5VZ87
resolver
uniprot
Q9C076
resolver
uniprot_entry
GA45G_HUMAN
resolver
uniprot_sec
Q5VZ87
resolver
uniprot_sec
Q9C076
resolver
amino_acid_sequence
MTLEEVRGQDTVPESTARMQGAGKALHELLLSAQRQGCLTAGVYESAKVLNVDPDNVTFCVLAAGEEDEGDIALQIHFTLIQAFCCENDIDIVRVGDVQRLAAIVGAGEEAGAPGDLHCILISNPNEDAWKDPALEKLSLFCEESRSVNDWVPSITLPE
uniprot
proteins
function
FUNCTION: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
uniprot
proteins
mass_dalton
17121
uniprot
proteins
mutagenesis
MUTAGEN 47; /note="A->R: 30-fold reduction in homodimerization affinity and 90% decrease in growth inhibition activity and ability to stop cell cycle; when associated with E-77, E-80 and R-83."; /evidence="ECO:0000269|PubMed:22058036"; MUTAGEN 76; /note="I->E: 30-fold reduction in homodimerization affinity and 90% decrease in growth inhibition activity and ability to stop cell cycle; when associated with R-47, E-80 and R-83."; /evidence="ECO:0000269|PubMed:22058036"; MUTAGEN 80; /note="L->E: 30-fold reduction in homodimerization affinity and 90% decrease in growth inhibition activity and ability to stop cell cycle; when associated with R-47, E-77 and R-83."; /evidence="ECO:0000269|PubMed:22058036"; MUTAGEN 83; /note="A->R: 30-fold reduction in homodimerization affinity and 90% decrease in growth inhibition activity and ability to stop cell cycle; when associated with R-47, E-77 and E-80."; /evidence="ECO:0000269|PubMed:22058036"; MUTAGEN 87; /note="E->K: Reduced growth inhibition activity; when associated with K-89."; /evidence="ECO:0000269|PubMed:22058036"; MUTAGEN 89; /note="D->K: Reduced growth inhibition activity; when associated with K-87."; /evidence="ECO:0000269|PubMed:22058036
uniprot
proteins
protein_family
GADD45 family
uniprot
proteins
pubmed
10597261
uniprot
proteins
pubmed
10773677
uniprot
proteins
pubmed
12716909
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22058036
uniprot
proteins
pubmed
9827804
uniprot
proteins
sequence_length
159
uniprot
proteins