Rdh16
entrez
299511
canonical
uniprot
P50170
canonical
ensembl
ENSRNOG00000081739
resolver
ensembl
ENSRNOG00055025879
resolver
ensembl
ENSRNOG00060007994
resolver
ensembl
ENSRNOG00065016700
resolver
ensp
ENSRNOP00000039311
resolver
ensp
ENSRNOP00055036548
resolver
ensp
ENSRNOP00060010015
resolver
ensp
ENSRNOP00065021961
resolver
enst
ENSRNOT00000051075
resolver
enst
ENSRNOT00055044643
resolver
enst
ENSRNOT00060013203
resolver
enst
ENSRNOT00065027840
resolver
genesymbol
Rdh16
resolver
genesymbol_syn
Rdh2
resolver
genesymbol_syn
Rodh1
resolver
genesymbol_syn
Rodhii
resolver
uniprot_entry
RDH16_RAT
resolver
amino_acid_sequence
MWLYLLALVGLWNLLRLFRERKVVSHLQDKYVFITGCDSGFGNLLARQLDRRGMRVLAACLTEKGAEQLRSKTSDRLETVILDVTKTESIVAATQWVKERVGNTGLWGLVNNAGISGHLGPNEWMNKQNIASVLDVNLLGMIEVTLSTVPLVRKARGRVVNVASIAGRLSFCGGGYCISKYGVEAFSDSLRRELSYFGVKVAIVEPGFFRTDVTNGVTLSSNFQMLWDQTSSEVREVYGENYLASYLKMLNGLDQRCNKDLSLVTDCMEHALTSCHPRTRYSAGWDAKFFYLPMSYLPTFLVDALFYWTSPKPEKAL
uniprot
proteins
ec_number
1.1.1.105
uniprot
proteins
ec_number
1.1.1.209
uniprot
proteins
ec_number
1.1.1.315
uniprot
proteins
ec_number
1.1.1.53
uniprot
proteins
function
FUNCTION: Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:7499345). Has higher activity towards CRBP-bound retinol than with free retinol (By similarity). Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (By similarity). {ECO:0000250|UniProtKB:O75452, ECO:0000269|PubMed:7499345}.
uniprot
proteins
mass_dalton
35597
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000269|PubMed:7499345}.
uniprot
proteins
post_translational_modification
PTM: Not N-glycosylated. {ECO:0000269|PubMed:11601977}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
11601977
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7499345
uniprot
proteins
pubmed
8251521
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:11601977}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11601977}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 289..308; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins