ABR
entrez
29
canonical
uniprot
Q12979
canonical
ensembl
ENSG00000159842
resolver
ensembl
ENSG00000276016
resolver
ensembl
ENSG00000278741
resolver
ensp
ENSP00000291107
resolver
ensp
ENSP00000303909
resolver
ensp
ENSP00000437429
resolver
ensp
ENSP00000442048
resolver
ensp
ENSP00000445198
resolver
ensp
ENSP00000461565
resolver
ensp
ENSP00000461629
resolver
ensp
ENSP00000480343
resolver
ensp
ENSP00000487391
resolver
enst
ENST00000536794
resolver
enst
ENST00000574139
resolver
enst
ENST00000619569
resolver
enst
ENST00000631260
resolver
genesymbol
ABR
resolver
hgnc
HGNC:81
resolver
uniprot
A0A0G2JN04
resolver
uniprot
B3KW89
resolver
uniprot
B7Z2X0
resolver
uniprot
B7Z683
resolver
uniprot
B7Z6H7
resolver
uniprot
B7Z7Z1
resolver
uniprot
D3DTH3
resolver
uniprot
D3DTH4
resolver
uniprot
F5H3S2
resolver
uniprot
F5H8B3
resolver
uniprot
I3L4Y1
resolver
uniprot
Q13693
resolver
uniprot
Q13694
resolver
uniprot
Q6ZT60
resolver
uniprot_entry
A0A0G2JN04_HUMAN
resolver
uniprot_entry
ABR_HUMAN
resolver
uniprot_entry
B7Z2X0_HUMAN
resolver
uniprot_entry
B7Z683_HUMAN
resolver
uniprot_entry
B7Z7Z1_HUMAN
resolver
uniprot_entry
I3L4Y1_HUMAN
resolver
uniprot_entry
Q6ZT60_HUMAN
resolver
uniprot_sec
B3KW89
resolver
uniprot_sec
B7Z6H7
resolver
uniprot_sec
D3DTH3
resolver
uniprot_sec
D3DTH4
resolver
uniprot_sec
F5H3S2
resolver
uniprot_sec
F5H8B3
resolver
uniprot_sec
Q13693
resolver
uniprot_sec
Q13694
resolver
amino_acid_sequence
MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV
uniprot
proteins
function
FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:7479768). The central Dbl homology (DH) domain functions as a guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). {ECO:0000250|UniProtKB:Q5SSL4, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:7479768}.
uniprot
proteins
mass_dalton
97598
uniprot
proteins
mutagenesis
MUTAGEN 683; /note="R->A: Reduces GAP activity. Loss of GAP activity; when associated with A-795."; /evidence="ECO:0000269|PubMed:17116687"; MUTAGEN 795; /note="N->A: Loss of GAP activity; when associated with A-683."; /evidence="ECO:0000269|PubMed:17116687"; MUTAGEN 859; /note="V->A: Abolishes interaction with DLG4. No effect on synaptic localization."; /evidence="ECO:0000269|PubMed:20962234
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17116687
uniprot
proteins
pubmed
20962234
uniprot
proteins
pubmed
2587217
uniprot
proteins
pubmed
7479768
uniprot
proteins
pubmed
8262969
uniprot
proteins
pubmed
8349582
uniprot
proteins
sequence_length
859
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q5SSL4}. Cell projection, axon {ECO:0000250|UniProtKB:Q5SSL4}. Synapse {ECO:0000250|UniProtKB:A0A0G2JTR4}.
uniprot
proteins