Pfn4
entrez
494222
canonical
uniprot
Q5IRJ7
canonical
ensembl
ENSRNOG00000050386
resolver
ensembl
ENSRNOG00055018606
resolver
ensembl
ENSRNOG00060012443
resolver
ensembl
ENSRNOG00065022477
resolver
ensp
ENSRNOP00000064666
resolver
ensp
ENSRNOP00055025592
resolver
ensp
ENSRNOP00060016652
resolver
ensp
ENSRNOP00065031047
resolver
enst
ENSRNOT00000074570
resolver
enst
ENSRNOT00055031662
resolver
enst
ENSRNOT00060021103
resolver
enst
ENSRNOT00065038335
resolver
genesymbol
Pfn4
resolver
uniprot_entry
PROF4_RAT
resolver
amino_acid_sequence
MSHLQNLLLDTLLGTKHVDGAALIKLQEKTLCVTSPGFSVMPCDVRTLLNGFAKNPLLTRREGLYFREKDYKCVRADDCSLYAKKENTGVVVVKTHMYLLVATYTAGMYPSVCVEATEKLGEYLRKKGN
uniprot
proteins
function
FUNCTION: Involved in male fertility. Required for manchette development and acrosome biogenesis during spermiogenesis (By similarity). Binds in vitro to phospholipids, including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Contrary to other profilin family members, does not bind to actin in vitro (By similarity). {ECO:0000250|UniProtKB:Q8NHR9, ECO:0000250|UniProtKB:Q9D6I3}.
uniprot
proteins
mass_dalton
14421
uniprot
proteins
protein_family
Profilin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15591451
uniprot
proteins
pubmed
19419568
uniprot
proteins
sequence_length
129
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19419568}. Note=In round spermatids, mainly observed in the acroplaxome. During the progression of spermiogenesis, relocalizes to the developing manchette of spermatids step 8 (S8). Coinciding with the initiation of manchette disassembly in spermatids S14, seen in the cytoplasm subjacent to the disassembling manchette. {ECO:0000269|PubMed:15591451, ECO:0000269|PubMed:19419568}.
uniprot
proteins