Rpgrip1l
entrez
244585
canonical
uniprot
Q8CG73
canonical
ensembl
ENSMUSG00000033282
resolver
ensp
ENSMUSP00000042702
resolver
ensp
ENSMUSP00000244721
resolver
ensp
ENSMUSP00000244722
resolver
ensp
ENSMUSP00000244723
resolver
ensp
ENSMUSP00000244724
resolver
enst
ENSMUST00000047783
resolver
genesymbol
Rpgrip1l
resolver
genesymbol_syn
Ftm
resolver
genesymbol_syn
Nphp8
resolver
uniprot
G3X958
resolver
uniprot_entry
FTM_MOUSE
resolver
uniprot_sec
G3X958
resolver
amino_acid_sequence
MSGPSDETAGDLPVKDTGLNLFGVGGLQETSTARTVKTRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELERQNEVLKNRLISAKQQLQVQGHRQTSYSRVQARVNTGRRRASASAGSQECPGKGLRFQNVDEAETVQPTLTKYSNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLKRKENEIELSLLQLREQQATDQRSNIRDNVETIKLHKQLVEKSNALSVIEGKFIQLQEKQRTLRISHDALMANGDELNKQLKEQRLKCCSLEKQLHSVRFSERRVEELQDRINDLEKERELLKENYDKLYNSAFSAAHEEQWKLKEQQMKVQIAQLETALKSDLTDKTEVLDKLKTERDQNEKLVQENRDLQLQCLQQKQRLHELQSRLKFFNQESDINADDLSEALLLIKAQKEQKNGDLSFLEKVDSKINKDLDRSMKELQATHAETVQELEKTRNMLIMQHKINKDYQMEVETVTQKMENLQQDYELKVEQYVHLLDIRAARIQKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLRASGDKELVTFCTYAFYDFELQTTPIVRGLYPEYNFTSQYLVHVNDLFLQYIQKNTVTLELHQAHSTDYETIAACQLRFHEILEKSGRIFCTTSLVGTKGDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKKPEKMQLSSQQAATTAQISPAESTDGNLNELHVTVKCCTGLQSRASYLQPHAYVVYKFFDFPDHDTAIVPSSNDPQFDDHMCFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYMGKVNVPLISLAHDKCISGIFELMDKEKHAAGTIQVILKWKFTYLPPSGSITTEDLGKFVCREEPEAVQRLPPKSSDVTSVVAPKPKPRQRLTFVDKKVSFADTISHPSPETSPPPKDIKDSSPEVGPKPENGLSAVAYPSKESGVAKVEENVGEMQQGKEDDISFLSEGQLASGSVASSEDETEITEELEPEDEDRSASDSDDCIIPSSVSTNTKQPSEEIRIEIIALNLNDSQITREDTIQRLFIECRFYSLPAEETPMSLPKPQSGQWVYYNYSNVIYLDKENNPAVRDILKAILQRRELPHRSVRFTVVSDPPEDEQDLECEDIGVAHVDLADLFQKGRDIIEQDIDVLDARTDGGTIGKLKVTVEALHALRSVYEQNRKDLEA
uniprot
proteins
function
FUNCTION: Negatively regulates signaling through the G protein-coupled thromboxane A2 receptor (TBXA2R) (By similarity). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (By similarity). Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins (PubMed:22927466). Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2 (PubMed:26150391). {ECO:0000250|UniProtKB:Q68CZ1, ECO:0000269|PubMed:10501967, ECO:0000269|PubMed:11956760, ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:22927466, ECO:0000269|PubMed:26150391}.
uniprot
proteins
mass_dalton
145000
uniprot
proteins
protein_family
RPGRIP1 family
uniprot
proteins
pubmed
10501967
uniprot
proteins
pubmed
11956760
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21565611
uniprot
proteins
pubmed
22927466
uniprot
proteins
pubmed
26150391
uniprot
proteins
sequence_length
1264
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:21565611}. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26150391}. Cell junction, tight junction {ECO:0000269|PubMed:21565611}. Note=In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions. Localizes to the ciliary transition zone. {ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:22927466, ECO:0000269|PubMed:26150391}.
uniprot
proteins