Kiss1
entrez
289023
canonical
uniprot
Q7TSB7
canonical
ensembl
ENSRNOG00000047481
resolver
ensembl
ENSRNOG00055021322
resolver
ensembl
ENSRNOG00060016607
resolver
ensembl
ENSRNOG00065020414
resolver
ensp
ENSRNOP00000099835
resolver
ensp
ENSRNOP00055029632
resolver
ensp
ENSRNOP00060022893
resolver
ensp
ENSRNOP00065027658
resolver
enst
ENSRNOT00000128335
resolver
enst
ENSRNOT00055036445
resolver
enst
ENSRNOT00060028442
resolver
enst
ENSRNOT00065034512
resolver
genesymbol
Kiss1
resolver
uniprot
J7H5M8
resolver
uniprot
J7HBH5
resolver
uniprot_entry
J7H5M8_RAT
resolver
uniprot_entry
KISS1_RAT
resolver
uniprot_sec
J7HBH5
resolver
amino_acid_sequence
MISLASWQLLLLLCVASFGEPLAKMAPVVNPEPTGQQSGPQELVNAWQKGPRYAESKPGAAGLRARRTSPCPPVENPTGHQRPPCATRSRLIPAPRGSVLVQREKDMSAYNWNSFGLRYGRRQVARAARG
uniprot
proteins
function
FUNCTION: Kisspeptins are ligands for the G protein-coupled receptor KISS1R/GPR54 (By similarity). The hypothalamic KISS1/KISS1R signaling system plays a central role in the regulation of the hypothalamic-pituitary-gonadal reproductive axis by modulating the secretion of gonadotropin-releasing hormone (GnRH) from GnRH neurons (PubMed:15219839, PubMed:15242985, PubMed:15500545, PubMed:15637288, PubMed:17698953). In these neurons, kisspeptin binding to its receptor activates G(q)-dependent signaling, leading to phospholipase C (PLC) activation, and hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2). The subsequent rise in intracellular calcium levels results in the inhibition of inward rectifier potassium channels and activation of TRPC-like cation channels, leading to GnRH neurons depolarization and stimulation. In addition to this pathway, kisspeptin also triggers G(q)-independent signaling via beta-arrestin, leading to MAPK cascade activation and ERK1/ERK2 phosphorylation (By similarity). Kisspeptins are also involved in the regulation of other processes including cell growth, cell proliferation and cell migration (By similarity). {ECO:0000250|UniProtKB:Q15726, ECO:0000269|PubMed:15219839, ECO:0000269|PubMed:15242985, ECO:0000269|PubMed:15500545, ECO:0000269|PubMed:15637288, ECO:0000269|PubMed:17698953}.; FUNCTION: [Kisspeptin-10]: Binds the G protein-coupled receptor KISS1R/GPR54 and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (By similarity). Binding to the receptor also activates beta-arrestin-dependent signaling resulting in ERK1/2 phosphorylation (By similarity). Activation of the receptor inhibits cell proliferation and cell migration, and is involved in the regulation of trophoblast invasion during early stages of pregnancy. Is also involved in the modulation of airway smooth muscle cells migration (By similarity). In bone tissue, activation of KISS1R by kisspeptin-10 recruits phosphatase DUSP18 and SRC to the KISS1R C-terminus through a G(q)-dependent signaling pathway. This leads to DUSP18-mediated dephosphorylation of SRC, down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (By similarity). {ECO:0000250|UniProtKB:Q15726, ECO:0000250|UniProtKB:Q6Y4S4}.; FUNCTION: [Metastin]: Receptor binding triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis by phospholipase C. {ECO:0000250|UniProtKB:Q15726}.
uniprot
proteins
mass_dalton
14188
uniprot
proteins
protein_family
KISS1 family
uniprot
proteins
pubmed
15157736
uniprot
proteins
pubmed
15219839
uniprot
proteins
pubmed
15242985
uniprot
proteins
pubmed
15500545
uniprot
proteins
pubmed
15593369
uniprot
proteins
pubmed
15637288
uniprot
proteins
pubmed
17698953
uniprot
proteins
sequence_length
130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17698953}.
uniprot
proteins