Mbtps2
entrez
270669
canonical
uniprot
Q8CHX6
canonical
ensembl
ENSMUSG00000046873
resolver
ensp
ENSMUSP00000059471
resolver
enst
ENSMUST00000058098
resolver
genesymbol
Mbtps2
resolver
uniprot
A2AC85
resolver
uniprot_entry
MBTP2_MOUSE
resolver
uniprot_sec
A2AC85
resolver
amino_acid_sequence
MIPVSLLVVVVGGWTAVYLADLVLKSSVYFKHSYEDWLENNGLSISPFHIRWQTSIFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSPYSSSSSSSSSSSSSSSSSSSLHNEQVLQVVVPGINLPVNQLTYFFAAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSFPVRAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRSNKDCKSGASSSFCIVPSLETHTRLIKVKHPPQIDMLYVGHPLHLHYTVSITSFIPRFNFLSIDLPVIVETFVKYLISLSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSVLLAANVTLGLWMVTAR
uniprot
proteins
ec_number
3.4.24.85
uniprot
proteins
function
FUNCTION: Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression. {ECO:0000250|UniProtKB:O43462}.
uniprot
proteins
mass_dalton
56960
uniprot
proteins
protein_family
Peptidase M50A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:O43462}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:O43462}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O43462}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 75..95; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 96..107; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 141..165; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..182; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 183..205; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..247; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 443..460; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 461..472; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 489..509; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins