Siglecg
entrez
243958
canonical
uniprot
Q80ZE3
canonical
ensembl
ENSMUSG00000030468
resolver
ensp
ENSMUSP00000005592
resolver
enst
ENSMUST00000005592
resolver
genesymbol
Siglec10
resolver
genesymbol
Siglecg
resolver
genesymbol_syn
Siglec10
resolver
genesymbol_syn
Siglecg
resolver
uniprot
Q8BY18
resolver
uniprot_entry
Q8BY18_MOUSE
resolver
uniprot_entry
SIG10_MOUSE
resolver
amino_acid_sequence
MSLLLFLLSFLLDGPQGQMESYFLQVQRIVKAQEGLCIFVPCSFSSPEGKWLNRSPLYGYWFKGIRKPSLSFPVATNNKDKVLEWEARGRFQLLGDISKKNCSLLIKDVQWGDSTNYFFRMERGFERFSFKEEFRLQVEALTQKPDIFIPEVLEPGEPVTVVCLFSWTFNQCPAPSFSWMGDAVSFQESRPHTSNYSVLSFIPGLQHHDTELTCQLDFSRMSTQRTVRLRVAYAPRSLAISIFHDNVSVPDLHENPSHLEVQQGQSLRLLCTADSQPPATLSWVLEDQVLSWSSPVGSRTLALELPWVKAGDSGHYTCQAENRLGSQQHTLDLSVLYPPQDLRVTVSQANRTVLEILRNAISLPVLEGQSLCLVCVTYSNPPANVSWAWVTQTLIPIQSSEPGVLELPLVQREHEGEFTCAAQNPLGAQRISLSLSVHYPPQMSSPSCSWEAKGLHCNCSSRAWPAPSLRWRLGEGLLEGNSSNASFTVTFSSLGPWVNSSLSLLQELGPSLWLSCESWNTHGAQTTSVLLLPDKDSATAFSKGAVLGFGITALLALCLIVVIVKTLQKKGTQEEPSRPKLSRGSTILDYINVVPKTRSLARNWKAEPDAPSRSSPLDTHFPKPKKKQKDPHFTYPGCPDPTSSSQVPVSENNPEELHYAALNFSRLRLQETQDPQDTYSDYTEVRVH
uniprot
proteins
function
FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (PubMed:20038598). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (By similarity). Involved in negative regulation of B-cell antigen receptor signaling and specifically acts on B1 cells to inhibit Ca(2+) signaling, cellular expansion and antibody secretion (PubMed:17572677). The inhibition of B cell activation is dependent on PTPN6/SHP-1 (PubMed:23836061). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (PubMed:19264983). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (By similarity). Plays a role in the control of autoimmunity (PubMed:20200274). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (PubMed:27548433). {ECO:0000250|UniProtKB:Q96LC7, ECO:0000269|PubMed:17572677, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20038598, ECO:0000269|PubMed:20200274, ECO:0000269|PubMed:27548433}.; FUNCTION: (Microbial infection) During infection by RNA viruses inhibits RIG-I signaling in macrophages by promoting its CBL-dependent ubiquitination and degradation via PTPN11/SHP-2. {ECO:0000269|PubMed:23374343}.
uniprot
proteins
mass_dalton
76884
uniprot
proteins
mutagenesis
MUTAGEN 120; /note="R->E: Decreases interaction with membrane IgM (with greater effect in B1a than in B2 cells)."; /evidence="ECO:0000269|PubMed:24790146"; MUTAGEN 590; /note="Y->F: Decreases interaction with RIGI; when associated with F-635, F-659 and F-682."; /evidence="ECO:0000269|PubMed:23374343"; MUTAGEN 635; /note="Y->F: Decreases interaction with RIGI; when associated with F-590, F-659 and F-682."; /evidence="ECO:0000269|PubMed:23374343"; MUTAGEN 659; /note="Y->F: Decreases interaction with RIGI; when associated with F-590,F-635 and F-682."; /evidence="ECO:0000269|PubMed:23374343"; MUTAGEN 682; /note="Y->F: Decreases interaction with RIGI; when associated with F-590, F-635 and F-659."; /evidence="ECO:0000269|PubMed:23374343
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Tyr-659 is involved in binding to PTPN6. {ECO:0000250|UniProtKB:Q96LC7}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
SIGLEC (sialic acid binding Ig-like lectin) family
uniprot
proteins
pubmed
14559209
uniprot
proteins
pubmed
17572677
uniprot
proteins
pubmed
19264983
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20038598
uniprot
proteins
pubmed
20200274
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23374343
uniprot
proteins
pubmed
23836061
uniprot
proteins
pubmed
24790146
uniprot
proteins
pubmed
27548433
uniprot
proteins
sequence_length
688
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96LC7}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 544..564; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins