Myocd
entrez
214384
canonical
uniprot
Q8VIM5
canonical
ensembl
ENSMUSG00000020542
resolver
ensp
ENSMUSP00000098603
resolver
ensp
ENSMUSP00000099695
resolver
ensp
ENSMUSP00000104335
resolver
genesymbol
Myocd
resolver
genesymbol_syn
Bsac2
resolver
genesymbol_syn
Mycd
resolver
genesymbol_syn
Srfcp
resolver
uniprot
Q5SS65
resolver
uniprot
Q6W8X1
resolver
uniprot
Q8C3W6
resolver
uniprot
Q8VIL4
resolver
uniprot_entry
MYCD_MOUSE
resolver
uniprot_sec
Q5SS65
resolver
uniprot_sec
Q6W8X1
resolver
uniprot_sec
Q8C3W6
resolver
uniprot_sec
Q8VIL4
resolver
amino_acid_sequence
MTLLGSEHSLLIRRKFRSVLQLRLQQRRTQEQLANQGLIPPLKGPTEFHDPRKQLDSAKTEDSLRRKGRNRSDRASLVTMHILQASTAERSIPTAQMKLKRARLADDLNEKIALRPGPLELVEKNILPMDSSVKEAIKGTEVSLSKAADAFAFEDDSSRDGLSPDQARSEDPQGSTGSTPDIKSTEAPLDTIQDLTPGSESDKNDAASQPGNQSDPGKQVLGPLSTPIPVHTAVKSKSLGDSKNRHKKPKDPKPKVKKLKYHQYIPPDQKAEKSPPPMDSAYARLLQQQQLFLQLQILSQQQQQQQQQQQQQQQQQQQQQRFSYPGMHQTHLKEPNEQMARNPNPSSTPLSNTPLSPVKNSISGQTGVSSLKPGPLPPNLDDLKVSELRQQLRIRGLPVSGTKTALVDRLRPFQDCAGNPVPNFGDITTVTFPVTPNTLPSYQSSPTGFYHFGSTSSSPPISPASSDLSAAGSLPDTFTDASPGFGLHASPVPACTDESLLSSLNGGSGPSEPDGLDSEKDKMLVEKQKVINQLTWKLRQEQRQVEELRMQLQKQKSSCSDQKPLPFLATTIKQEDVSSCPFAPQQASGKGQGHSSDSPPPACETAQLLPHCVESSGQTHVLSSTFLSPQCSPQHSPLGGLKSPQHISLPPSPNNHYFLASSSGAQRENHGVSSPSSSQGCAQMTGLQSSDKVGPTFSIPSPTFSKSSSAVSDITQPPSYEDAVKQQMTRSQQMDELLDVLIESGEMPADAREDHSCLQKIPKIPGSSCSPTAIPPKPSASFEQASSGGQMAFDHYANDSDEHLEVLLNSHSPIGKVSDVTLLKIGSEEPPFDSIMDGFPGKAAEDLFSAHELLPGPLSPMHAQLSPPSVDSSGLQLSFTESPWETMEWLDLTPPSSTPGFSNLTSSGPSIFNIDFLDVTDLNLNSPMDLHLQQW
uniprot
proteins
function
FUNCTION: Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis). Positively regulates the transcription of genes involved in vascular smooth muscle contraction (By similarity). {ECO:0000250|UniProtKB:Q8R5I7, ECO:0000269|PubMed:11439182, ECO:0000269|PubMed:12640126, ECO:0000269|PubMed:12663482, ECO:0000269|PubMed:16818234, ECO:0000269|PubMed:20385216, ECO:0000269|PubMed:31513549}.; FUNCTION: [Isoform 1]: Positively regulates the activation of smooth muscle cell gene promoter regions. {ECO:0000269|PubMed:20385216}.; FUNCTION: [Isoform 3]: Positively regulates the activation of smooth muscle cell gene promoter regions (PubMed:20385216). Activation of the MYH6 promoter is enhanced in the presence of MEF2C (PubMed:20385216). {ECO:0000269|PubMed:20385216}.; FUNCTION: [Isoform 4]: Positively regulates the activation of smooth muscle cell gene promoter regions. {ECO:0000269|PubMed:20385216}.; FUNCTION: [Isoform 5]: Positively regulates the activation of smooth muscle cell gene promoter regions. {ECO:0000269|PubMed:20385216}.
uniprot
proteins
mass_dalton
101400
uniprot
proteins
mutagenesis
MUTAGEN 387..389; /note="ELR->PSF: Activation of ANF promoter abolished, no effect on SM22 promoter."; /evidence="ECO:0000269|PubMed:11439182"; MUTAGEN 408..410; /note="DRL->PGH: Activation of ANF promoter abolished, no effect on SM22 promoter."; /evidence="ECO:0000269|PubMed:11439182"; MUTAGEN 812; /note="S->A: No effect on SRF activation. No effect on SRF activation, on interaction with EP300 and on SM-promoter activation; when associated with A-859; A-866 and A-893."; /evidence="ECO:0000269|PubMed:19776005"; MUTAGEN 812; /note="S->D: No effect on SRF activation. Impairs SRF activation, reduces interaction with EP300 and SM-promoter activation; when associated with D-859; D-866 and D-893."; /evidence="ECO:0000269|PubMed:19776005"; MUTAGEN 859; /note="S->A: No effect on SRF activation; No effect on SRF activation. No effect on SRF activation, on interaction with EP300 and on SM-promoter activation; when associated with A-812, A-866 and A-893."; /evidence="ECO:0000269|PubMed:19776005"; MUTAGEN 859; /note="S->D: No effect on SRF activation. Impairs SRF activation, reduces interaction with EP300 and SM-promoter activation; when associated with D-812; D-866 and D-893."; /evidence="ECO:0000269|PubMed:19776005"; MUTAGEN 866; /note="S->A: No effect on SRF activation; No effect on SRF activation, on interaction with EP300 and on SM-promoter activation; when associated with A-812; A-859 and A-893."; /evidence="ECO:0000269|PubMed:19776005"; MUTAGEN 866; /note="S->D: No effect on SRF activation. Impairs SRF activation, reduces interaction with EP300 and SM-promoter activation; when associated with D-812; D-859 and D-893."; /evidence="ECO:0000269|PubMed:19776005"; MUTAGEN 893; /note="T->A: No effect on SRF activation; No effect on SRF activation, on interaction with EP300 and on SM-specific genes transcription; when associated with A-812; A-859 and A-866."; /evidence="ECO:0000269|PubMed:19776005"; MUTAGEN 893; /note="T->D: No effect on SRF activation. Impairs SRF activation, reduces interaction with EP300 and SM-promoter activation; when associated with D-812; D-859 and D-866."; /evidence="ECO:0000269|PubMed:19776005
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; by STUB1/CHIP at the C-terminus, leading to its degradation by the proteasome (PubMed:19237536). Phosphorylation by GSK3B is required for STUB1/CHIP-mediated ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q8R5I7, ECO:0000269|PubMed:19237536}.; PTM: Phosphorylation negatively regulates transcriptional activity (PubMed:16141410, PubMed:19776005). Phosphorylated; by GSK3B (PubMed:19237536). {ECO:0000269|PubMed:16141410, ECO:0000269|PubMed:19237536, ECO:0000269|PubMed:19776005}.
uniprot
proteins
pubmed
11439182
uniprot
proteins
pubmed
12397177
uniprot
proteins
pubmed
12640126
uniprot
proteins
pubmed
12663482
uniprot
proteins
pubmed
14645532
uniprot
proteins
pubmed
15601857
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16141410
uniprot
proteins
pubmed
16818234
uniprot
proteins
pubmed
19237536
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19776005
uniprot
proteins
pubmed
20385216
uniprot
proteins
pubmed
31513549
uniprot
proteins
pubmed
33743134
uniprot
proteins
sequence_length
935
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:11439182, ECO:0000269|PubMed:15601857}. Note=Nuclear, with a punctate intranuclear pattern with exclusion from nuclei.
uniprot
proteins