LDLRAD4
entrez
753
canonical
uniprot
O15165
canonical
ensembl
ENSG00000168675
resolver
ensp
ENSP00000352420
resolver
ensp
ENSP00000382741
resolver
ensp
ENSP00000466178
resolver
ensp
ENSP00000466772
resolver
ensp
ENSP00000474783
resolver
ensp
ENSP00000503185
resolver
ensp
ENSP00000504022
resolver
ensp
ENSP00000504217
resolver
ensp
ENSP00000504396
resolver
ensp
ENSP00000504651
resolver
ensp
ENSP00000566386
resolver
ensp
ENSP00000566387
resolver
ensp
ENSP00000566388
resolver
ensp
ENSP00000566389
resolver
ensp
ENSP00000566390
resolver
ensp
ENSP00000566391
resolver
ensp
ENSP00000566392
resolver
ensp
ENSP00000566397
resolver
ensp
ENSP00000566399
resolver
ensp
ENSP00000613694
resolver
ensp
ENSP00000613695
resolver
ensp
ENSP00000613696
resolver
ensp
ENSP00000613699
resolver
enst
ENST00000677055
resolver
enst
ENST00000679167
resolver
enst
ENST00000679177
resolver
genesymbol
LDLRAD4
resolver
genesymbol_syn
C18orf1
resolver
hgnc
HGNC:1224
resolver
uniprot
A0A7I2V575
resolver
uniprot
A8K6A9
resolver
uniprot
B3KNT9
resolver
uniprot
E9PAY9
resolver
uniprot
K7EN38
resolver
uniprot
O15166
resolver
uniprot
O15167
resolver
uniprot
O15168
resolver
uniprot
Q5U646
resolver
uniprot
Q6NXP3
resolver
uniprot_entry
A0A7I2V575_HUMAN
resolver
uniprot_entry
A8K6A9_HUMAN
resolver
uniprot_entry
LRAD4_HUMAN
resolver
uniprot_sec
B3KNT9
resolver
uniprot_sec
E9PAY9
resolver
uniprot_sec
K7EN38
resolver
uniprot_sec
O15166
resolver
uniprot_sec
O15167
resolver
uniprot_sec
O15168
resolver
uniprot_sec
Q5U646
resolver
uniprot_sec
Q6NXP3
resolver
amino_acid_sequence
MPEAGFQATNAFTECKFTCTSGKCLYLGSLVCNQQNDCGDNSDEENCLLVTEHPPPGIFNSELEFAQIIIIVVVVTVMVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQEGCLWPSDSAAPRLGASEIMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAHRGSRLQFQQNNAESTIVPIKGKDRKPGNLV
uniprot
proteins
function
FUNCTION: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. {ECO:0000269|PubMed:24627487}.
uniprot
proteins
mass_dalton
33900
uniprot
proteins
protein_family
PMEPA1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
19461657
uniprot
proteins
pubmed
24627487
uniprot
proteins
pubmed
9479497
uniprot
proteins
sequence_length
306
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:24627487}; Single-pass membrane protein {ECO:0000269|PubMed:24627487}.
uniprot
proteins
transmembrane_region
TRANSMEM 65..85; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins