Mta1
entrez
116870
canonical
uniprot
Q8K4B0
canonical
ensembl
ENSMUSG00000021144
resolver
ensp
ENSMUSP00000009099
resolver
ensp
ENSMUSP00000064338
resolver
ensp
ENSMUSP00000105345
resolver
ensp
ENSMUSP00000105348
resolver
ensp
ENSMUSP00000105349
resolver
ensp
ENSMUSP00000272893
resolver
ensp
ENSMUSP00000272894
resolver
ensp
ENSMUSP00000272895
resolver
ensp
ENSMUSP00000272896
resolver
ensp
ENSMUSP00000272898
resolver
ensp
ENSMUSP00000272899
resolver
ensp
ENSMUSP00000272902
resolver
ensp
ENSMUSP00000272904
resolver
enst
ENSMUST00000009099
resolver
enst
ENSMUST00000069690
resolver
enst
ENSMUST00000109723
resolver
enst
ENSMUST00000109726
resolver
enst
ENSMUST00000109727
resolver
genesymbol
Mta1
resolver
uniprot
E9PX23
resolver
uniprot
F8WHY8
resolver
uniprot
M1VB34
resolver
uniprot
M1VHG1
resolver
uniprot
M1VHG3
resolver
uniprot
M1VHG6
resolver
uniprot
M1VMF4
resolver
uniprot
M1VMF6
resolver
uniprot
Q2KHS8
resolver
uniprot
Q80UI1
resolver
uniprot
Q8K4D4
resolver
uniprot
Q924K9
resolver
uniprot_entry
E9PX23_MOUSE
resolver
uniprot_entry
F8WHY8_MOUSE
resolver
uniprot_entry
M1VB34_MOUSE
resolver
uniprot_entry
M1VHG1_MOUSE
resolver
uniprot_entry
M1VHG3_MOUSE
resolver
uniprot_entry
M1VHG6_MOUSE
resolver
uniprot_entry
M1VMF4_MOUSE
resolver
uniprot_entry
M1VMF6_MOUSE
resolver
uniprot_entry
MTA1_MOUSE
resolver
uniprot_entry
Q2KHS8_MOUSE
resolver
uniprot_sec
Q80UI1
resolver
uniprot_sec
Q8K4D4
resolver
uniprot_sec
Q924K9
resolver
amino_acid_sequence
MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSSLIALADKHATLSVCYRAGPGADTGEEGEVEEEVENPEMVDLPEKLKHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDLLKEGEEDGRDQSKLETKVWEAHNPLVDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYNKPNPNQISASSVKATVVNGTGTPGQSPGAGRACESCYTTQSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRNNMSPHGIPARSSGSPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYMPINSAAIKAECTARLPEASQSPLVLKQVVRKPLEAVLRYLETHPRPPKPDPVKSSSSVLSSLTPAKSAPVINNGSPTILGKRSYEQHNGVDGNMKKRLLMPSRGLANHGQTRHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWIDAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPLRPPPPAPVNDEPIVIED
uniprot
proteins
function
FUNCTION: Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:20071335, PubMed:20682799). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:20071335, PubMed:21965678). Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex (PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (PubMed:20682799). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19805145, PubMed:20071335). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19805145, PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (PubMed:24089055). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (PubMed:24089055). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (PubMed:24089055). With Tfcp2l1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (PubMed:28982712). {ECO:0000250|UniProtKB:Q13330, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:19805145, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:20071335, ECO:0000269|PubMed:20682799, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24089055, ECO:0000269|PubMed:28982712}.
uniprot
proteins
mass_dalton
80798
uniprot
proteins
mutagenesis
MUTAGEN 322; /note="S->A: Reduction in the ability of MTA1S to repress ER transactivation."; /evidence="ECO:0000269|PubMed:15077195
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by CSNK1G2/CK1 triggered by estrogen enhances corepression of estrogen receptor (ER). {ECO:0000269|PubMed:15077195}.; PTM: Acetylation is essential for its transcriptional coactivator activity. {ECO:0000250}.; PTM: Sumoylation positively regulates its transcriptional corepressor activity but does not affect the protein stability. Sumoylated preferentially by SUMO2 or SUMO3 than SUMO1. Sumoylation is enhanced by PIAS1/3/4 and preferentially sumoylated by SUMO2 in the presence of PIAS1/3/4. Desumoylated by SENP1 (By similarity). {ECO:0000250}.; PTM: Ubiquitinated by COP1, which leads to proteasomal degradation. {ECO:0000250}.
uniprot
proteins
protein_family
Metastasis-associated protein family
uniprot
proteins
pubmed
11483358
uniprot
proteins
pubmed
12370427
uniprot
proteins
pubmed
15077195
uniprot
proteins
pubmed
16617102
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17666527
uniprot
proteins
pubmed
17671180
uniprot
proteins
pubmed
19805145
uniprot
proteins
pubmed
19837670
uniprot
proteins
pubmed
20071335
uniprot
proteins
pubmed
20519513
uniprot
proteins
pubmed
20682799
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21965678
uniprot
proteins
pubmed
24089055
uniprot
proteins
pubmed
24970816
uniprot
proteins
pubmed
27806305
uniprot
proteins
pubmed
28314777
uniprot
proteins
pubmed
28982712
uniprot
proteins
pubmed
30228260
uniprot
proteins
pubmed
34180153
uniprot
proteins
sequence_length
715
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11483358, ECO:0000269|PubMed:20682799, ECO:0000269|PubMed:24970816}. Nucleus envelope {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624}. Cytoplasm {ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:20682799, ECO:0000269|PubMed:24970816}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q13330}. Note=Associated with microtubules. Primarily localized in the cytoplasm in embryonic tissues (PubMed:24970816). Localization at the nuclear envelope is TPR-dependent (By similarity). {ECO:0000250|UniProtKB:Q13330, ECO:0000269|PubMed:24970816}.
uniprot
proteins