SYCE3
entrez
644186
canonical
uniprot
A1L190
canonical
ensembl
ENSG00000217442
resolver
ensp
ENSP00000385122
resolver
ensp
ENSP00000385480
resolver
ensp
ENSP00000763969
resolver
enst
ENST00000402753
resolver
enst
ENST00000406915
resolver
genesymbol
SYCE3
resolver
genesymbol_syn
C22orf41
resolver
genesymbol_syn
THEG2
resolver
hgnc
HGNC:35245
resolver
uniprot_entry
SYCE3_HUMAN
resolver
amino_acid_sequence
MDDADPEERNYDNMLKMLSDLNKDLEKLLEEMEKISVQATWMAYDMVVMRTNPTLAESMRRLEDAFVNCKEEMEKNWQELLHETKQRL
uniprot
proteins
function
FUNCTION: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:36635604). Required for the assembly of the central element of the synaptonemal complex during meiosis, via remodeling of SYCP1 lattice structures and promoting recruitment of SYCE2-TEX12 and SYCE1-SIX60S1 complexes (PubMed:36635604). Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes (By similarity). Chromosome loading appears to require SYCP1 (By similarity). Required for fertility and normal testis development (By similarity). {ECO:0000250|UniProtKB:B5KM66, ECO:0000269|PubMed:36635604}.
uniprot
proteins
mass_dalton
10601
uniprot
proteins
mutagenesis
MUTAGEN 41; /note="W->E: Abolishes formation of higher-order homooligomers; when associated with E-44. Abolishes interaction between SYCP1/SYCE3 heterotrimers; when associated with E-44."; /evidence="ECO:0000269|PubMed:31023827, ECO:0000269|PubMed:36635604"; MUTAGEN 44; /note="Y->E: Abolishes formation of higher-order homooligomers; when associated with E-41. Abolishes interaction between SYCP1/SYCE3 heterotrimers; when associated with E-41."; /evidence="ECO:0000269|PubMed:31023827, ECO:0000269|PubMed:36635604"; MUTAGEN 53; /note="P->Q: Promotes formation of higher-order homooligomers."; /evidence="ECO:0000269|PubMed:31023827
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
31023827
uniprot
proteins
pubmed
36635604
uniprot
proteins
sequence_length
88
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:B5KM66}. Chromosome {ECO:0000250|UniProtKB:B5KM66}. Note=Colocalizes with SYCE1 in the central elements. {ECO:0000250|UniProtKB:B5KM66}.
uniprot
proteins