IFT25
entrez
51668
canonical
uniprot
Q9Y547
canonical
ensembl
ENSG00000081870
resolver
ensp
ENSP00000194214
resolver
ensp
ENSP00000360429
resolver
ensp
ENSP00000569956
resolver
ensp
ENSP00000569957
resolver
ensp
ENSP00000569958
resolver
ensp
ENSP00000569959
resolver
ensp
ENSP00000569960
resolver
ensp
ENSP00000569961
resolver
ensp
ENSP00000569962
resolver
ensp
ENSP00000569963
resolver
ensp
ENSP00000569964
resolver
ensp
ENSP00000595738
resolver
ensp
ENSP00000595739
resolver
ensp
ENSP00000681876
resolver
enst
ENST00000194214
resolver
enst
ENST00000371378
resolver
enst
ENST00000899897
resolver
enst
ENST00000899898
resolver
enst
ENST00000899899
resolver
enst
ENST00000899901
resolver
enst
ENST00000899902
resolver
enst
ENST00000899904
resolver
enst
ENST00000899905
resolver
enst
ENST00000925679
resolver
enst
ENST00000925680
resolver
genesymbol
IFT25
resolver
genesymbol_syn
C1orf41
resolver
genesymbol_syn
HSPB11
resolver
hgnc
HGNC:25019
resolver
uniprot
A6NG57
resolver
uniprot
D3DQ45
resolver
uniprot
Q9Y684
resolver
uniprot
X6R7Y7
resolver
uniprot_entry
IFT25_HUMAN
resolver
uniprot_entry
X6R7Y7_HUMAN
resolver
uniprot_sec
A6NG57
resolver
uniprot_sec
D3DQ45
resolver
uniprot_sec
Q9Y684
resolver
amino_acid_sequence
MRKIDLCLSSEGSEVILATSSDEKHPPENIIDGNPETFWTTTGMFPQEFIICFHKHVRIERLVIQSYFVQTLKIEKSTSKEPVDFEQWIEKDLVHTEGQLQNEEIVAHDGSATYLRFIIVSAFDHFASVHSVSAEGTVVSNLSS
uniprot
proteins
function
FUNCTION: Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity). {ECO:0000250|UniProtKB:Q9D6H2}.
uniprot
proteins
mass_dalton
16297
uniprot
proteins
protein_family
IFT25 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18816799
uniprot
proteins
pubmed
19921466
uniprot
proteins
pubmed
2018407
uniprot
proteins
pubmed
21269460
uniprot
proteins
sequence_length
144
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q9D6H2}.
uniprot
proteins