LAT
entrez
27040
canonical
uniprot
O43561
canonical
ensembl
ENSG00000213658
resolver
ensp
ENSP00000354119
resolver
ensp
ENSP00000378841
resolver
ensp
ENSP00000378845
resolver
ensp
ENSP00000398793
resolver
genesymbol
LAT
resolver
hgnc
HGNC:18874
resolver
uniprot
B7WPI0
resolver
uniprot
C7C5T6
resolver
uniprot
G5E9K3
resolver
uniprot
O43919
resolver
uniprot_entry
LAT_HUMAN
resolver
uniprot_sec
B7WPI0
resolver
uniprot_sec
C7C5T6
resolver
uniprot_sec
G5E9K3
resolver
uniprot_sec
O43919
resolver
amino_acid_sequence
MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEGASGIRGAQAGWGVWGPSWTRLTPVSLPPEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 52 (IMD52) [MIM:617514]: An autosomal recessive primary immunodeficiency characterized by T-cell abnormalities, resulting in severe combined immunodeficiency, autoimmune disease, progressive lymphopenia and hypogammaglobulinemia, and lymphoproliferation with splenomegaly. Patients develop severe recurrent infections from infancy. {ECO:0000269|PubMed:27242165, ECO:0000269|PubMed:27522155}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}.
uniprot
proteins
mass_dalton
27930
uniprot
proteins
mutagenesis
MUTAGEN 26; /note="C->A: Reduces palmitoylation; abolishes localization to lipid rafts."; /evidence="ECO:0000269|PubMed:9729044"; MUTAGEN 29; /note="C->A: Reduces palmitoylation; impairs localization to lipid rafts."; /evidence="ECO:0000269|PubMed:9729044"; MUTAGEN 161; /note="Y->F: Abolishes interaction with PLCG1."; /evidence="ECO:0000269|PubMed:11368773"; MUTAGEN 200; /note="Y->F: Abolishes interaction with GRB2 and PIK3R1; when associated with F-220."; /evidence="ECO:0000269|PubMed:9489702"; MUTAGEN 220; /note="Y->F: Abolishes interaction with GRB2 and PIK3R1; when associated with F-200."; /evidence="ECO:0000269|PubMed:9489702
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes.; PTM: Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation. {ECO:0000269|PubMed:9729044}.; PTM: 'Lys-63'-linked ubiquitinated by TRAF6. {ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}.
uniprot
proteins
pubmed
10072481
uniprot
proteins
pubmed
10488157
uniprot
proteins
pubmed
10781611
uniprot
proteins
pubmed
10811803
uniprot
proteins
pubmed
10942756
uniprot
proteins
pubmed
11259588
uniprot
proteins
pubmed
11368773
uniprot
proteins
pubmed
12186560
uniprot
proteins
pubmed
12913111
uniprot
proteins
pubmed
14696041
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16160011
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23514740
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25907557
uniprot
proteins
pubmed
27242165
uniprot
proteins
pubmed
27522155
uniprot
proteins
pubmed
9489702
uniprot
proteins
pubmed
9529333
uniprot
proteins
pubmed
9729044
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}; Single-pass type III membrane protein {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}. Note=Present in lipid rafts.
uniprot
proteins
transmembrane_region
TRANSMEM 5..27; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins