TFB2M
entrez
64216
canonical
uniprot
Q9H5Q4
canonical
ensembl
ENSG00000162851
resolver
ensp
ENSP00000355471
resolver
ensp
ENSP00000543680
resolver
enst
ENST00000366514
resolver
genesymbol
TFB2M
resolver
genesymbol_syn
NS5ATP5
resolver
hgnc
HGNC:18559
resolver
uniprot
Q9H626
resolver
uniprot_entry
TFB2M_HUMAN
resolver
uniprot_sec
Q9H626
resolver
amino_acid_sequence
MWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLAQIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKNLGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKLMADPGNPDLYHVLSVIWQLACEIKVLHMEPWSSFDIYTRKGPLENPKRRELLDQLQQKLYLIQMIPRQNLFTKNLTPMNYNIFFHLLKHCFGRRSATVIDHLRSLTPLDARDILMQIGKQEDEKVVNMHPQDFKTLFETIERSKDCAYKWLYDETLEDR
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:12068295, PubMed:15526033, PubMed:20410300, PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:15526033, PubMed:29149603). Stimulates transcription independently of the methyltransferase activity (PubMed:12897151). {ECO:0000269|PubMed:12068295, ECO:0000269|PubMed:12897151, ECO:0000269|PubMed:15526033, ECO:0000269|PubMed:20410300, ECO:0000269|PubMed:29149603, ECO:0000305|PubMed:12897151, ECO:0000305|PubMed:17031457}.
uniprot
proteins
mass_dalton
45349
uniprot
proteins
mutagenesis
MUTAGEN 105; /note="G->A: Abolishes methyltransferase activity."; /evidence="ECO:0000269|PubMed:17031457"; MUTAGEN 330; /note="R->A: Impairs transcription initiation; when associated with A-331."; /evidence="ECO:0000269|PubMed:29149603"; MUTAGEN 331; /note="R->A: Impairs transcription initiation; when associated with A-330."; /evidence="ECO:0000269|PubMed:29149603
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
KsgA subfamily
uniprot
proteins
protein_family
rRNA adenine N(6)-methyltransferase family
uniprot
proteins
pubmed
12068295
uniprot
proteins
pubmed
12897151
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15526033
uniprot
proteins
pubmed
15684387
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17031457
uniprot
proteins
pubmed
18980857
uniprot
proteins
pubmed
19096125
uniprot
proteins
pubmed
20410300
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
29149603
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion.
uniprot
proteins