Supt5h
entrez
20924
canonical
uniprot
O55201
canonical
ensembl
ENSMUSG00000003435
resolver
ensp
ENSMUSP00000003527
resolver
ensp
ENSMUSP00000227603
resolver
ensp
ENSMUSP00000227605
resolver
genesymbol
Supt5h
resolver
genesymbol_syn
Supt5
resolver
uniprot
Q3UJ77
resolver
uniprot
Q3UJH1
resolver
uniprot
Q3UKD7
resolver
uniprot
Q3UM54
resolver
uniprot
Q6PB73
resolver
uniprot
Q6PDP0
resolver
uniprot
Q6PFR4
resolver
uniprot_entry
SPT5H_MOUSE
resolver
uniprot_sec
Q3UJ77
resolver
uniprot_sec
Q3UJH1
resolver
uniprot_sec
Q3UKD7
resolver
uniprot_sec
Q3UM54
resolver
uniprot_sec
Q6PB73
resolver
uniprot_sec
Q6PDP0
resolver
uniprot_sec
Q6PFR4
resolver
amino_acid_sequence
MSDSEDSNFSEEEDSERSSEAEEAEVEEDQRSAAGSEKEEEPEEEEEEEEEYDEEEEEEDDDRPPKKPRHGGFILDEADVDDEYEDEDQWEDGAEDILEKEEIEASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYMKKYAKSSVGETVYGGSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYIYVEAYKQTHVKQAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPKSWVRLKRGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARMSLKDWFAKRKKFKRPPQRLFDAEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTESTGKEREHNFQPGDNVEVCEGELINLQGKVLSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVILFSDLTMHELKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPRTVGVIVRLERETFQVLNMHGKVVTVRHQAVTQKKDNRFAVALDSDQNNIHVKDIVKVIDGPHSGREGEIRHLYRSFAFLHCKKLVENGGMFVCKARHLVLAGGSKPRDVTNLTVGGFTPMSPRISSPMHPSAEGQHGGFGSPGGMSRGRGRRDNELIGQTVRISQGPYKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVDSQRPGGMTSTYGRTPMYGSQTPMYGSGSRTPMYGSQTPLQDGSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPGAPSPGGYNPHTPGSGIEQNSSDWVTTDIQVKVRDTYLDTQIVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHLEPITPTKNNKVKVILGEDREATGVLLSIDGEDGIIRMDLEDQQIKILNLRFLGKLLEA
uniprot
proteins
function
FUNCTION: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation. {ECO:0000250|UniProtKB:O00267}.
uniprot
proteins
mass_dalton
120664
uniprot
proteins
post_translational_modification
PTM: Methylated by PRMT1/HRMT1L2 and PRMT5/SKB1. Methylation negatively regulates interaction with P-TEFb and RNA polymerase II. {ECO:0000250|UniProtKB:O00267}.; PTM: Phosphorylated by CDK7 and CDK9. Phosphorylation by P-TEFb (CDK9) at Thr residues of the C-terminal repeats alleviates transcriptional pausing and promotes transcription elongation. Dephosphorylated by the INTAC complex when transcripts are unfavorably configured for transcriptional elongation, leading to premature transcription termination: dephosphorylation is mediated by the PPP2CA component of the INTAC complex. Dephosphorylated by the PNUTS-PP1 complex in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription. Dephosphorylated by the PNUTS-PP1 complex in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription. Phosphorylation may also stimulate interaction with PIN1. Bulk phosphorylation occurs predominantly in mitosis. {ECO:0000250|UniProtKB:O00267}.; PTM: Ubiquitinated by UBR5 when not assembled in the DSIF complex, leading to its degradation: UBR5 recognizes and binds a degron that is not accessible when SUPT5H is part of the DSIF complex. {ECO:0000250|UniProtKB:O00267}.
uniprot
proteins
protein_family
SPT5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
9480761
uniprot
proteins
sequence_length
1082
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O00267}.
uniprot
proteins