TENT5C
entrez
54855
canonical
uniprot
Q5VWP2
canonical
ensembl
ENSG00000183508
resolver
ensp
ENSP00000358458
resolver
ensp
ENSP00000550549
resolver
ensp
ENSP00000550550
resolver
ensp
ENSP00000550551
resolver
ensp
ENSP00000550552
resolver
ensp
ENSP00000550553
resolver
enst
ENST00000369448
resolver
enst
ENST00000880490
resolver
enst
ENST00000880491
resolver
enst
ENST00000880492
resolver
enst
ENST00000880493
resolver
enst
ENST00000880494
resolver
genesymbol
TENT5C
resolver
genesymbol_syn
FAM46C
resolver
hgnc
HGNC:24712
resolver
uniprot
A3KMG2
resolver
uniprot
Q8NE25
resolver
uniprot
Q9NXK0
resolver
uniprot_entry
TET5C_HUMAN
resolver
uniprot_sec
A3KMG2
resolver
uniprot_sec
Q8NE25
resolver
uniprot_sec
Q9NXK0
resolver
amino_acid_sequence
MAEESSCTRDCMSFSVLNWDQVSRLHEVLTEVVPIHGRGNFPTLEITLKDIVQTVRSRLEEAGIKVHDVRLNGSAAGHVLVKDNGLGCKDLDLIFHVALPTEAEFQLVRDVVLCSLLNFLPEGVNKLKISPVTLKEAYVQKLVKVCTDTDRWSLISLSNKNGKNVELKFVDSIRRQFEFSVDSFQIILDSLLFFYDCSNNPISEHFHPTVIGESMYGDFEEAFDHLQNRLIATKNPEEIRGGGLLKYSNLLVRDFRPTDQEEIKTLERYMCSRFFIDFPDILEQQRKLETYLQNHFAEEERSKYDYLMILRRVVNESTVCLMGHERRQTLNLISLLALRVLAEQNIIPSATNVTCYYQPAPYVSDGNFSNYYVAHPPVTYSQPYPTWLPCN
uniprot
proteins
ec_number
2.7.7.19
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression (PubMed:28931820, PubMed:32009146, PubMed:34048638). Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich (PubMed:34048638). Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein (PubMed:28931820). {ECO:0000269|PubMed:28931820, ECO:0000269|PubMed:32009146, ECO:0000269|PubMed:34048638}.; FUNCTION: (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon. {ECO:0000269|PubMed:21478870}.
uniprot
proteins
mass_dalton
44944
uniprot
proteins
mutagenesis
MUTAGEN 90..92; /note="DLD->ALA: Loss of poly(a) polymerase activity."; /evidence="ECO:0000269|PubMed:28931820"; MUTAGEN 144; /note="K->P: Decreases substantially the interaction with PLK4. Weakens binding to PLK4; when associated with E-230 and E-321. Abolishes the inhibitory effect of TENT5C on the cell viability; when associated with E-320 and E-321."; /evidence="ECO:0000269|PubMed:32433990"; MUTAGEN 146; /note="C->P: Decreases substantially the interaction with PLK4. Weakens binding to PLK4; when associated with E-230 and E-321."; /evidence="ECO:0000269|PubMed:32433990"; MUTAGEN 166; /note="E->Q: Does not affect colocalization with PLK4 in centrosome. Increases cell viability."; /evidence="ECO:0000269|PubMed:32433990"; MUTAGEN 320; /note="C->E: Slightly decreases the binding to PLK4; when associated with E-321. Abolishes the inhibitory effect of TENT5C on the cell viability; when associated with P-144 and E-321."; /evidence="ECO:0000269|PubMed:32433990"; MUTAGEN 321; /note="L->E: Slightly decreases the binding to PLK4; when associated with E-320. Abolishes the inhibitory effect of TENT5C on the cell viability; when associated with P-144 and E-320."; /evidence="ECO:0000269|PubMed:32433990
uniprot
proteins
protein_family
TENT family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21478870
uniprot
proteins
pubmed
28931820
uniprot
proteins
pubmed
32009146
uniprot
proteins
pubmed
32433990
uniprot
proteins
pubmed
34048638
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28931820}. Cytoplasm {ECO:0000269|PubMed:28931820}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:32433990}. Note=Recruited into the centrosome through its interaction with PLK4. {ECO:0000269|PubMed:32433990}.
uniprot
proteins