Il1r2
entrez
16178
canonical
uniprot
P27931
canonical
ensembl
ENSMUSG00000026073
resolver
ensp
ENSMUSP00000027243
resolver
ensp
ENSMUSP00000203056
resolver
ensp
ENSMUSP00000203057
resolver
ensp
ENSMUSP00000203058
resolver
ensp
ENSMUSP00000203059
resolver
ensp
ENSMUSP00000355967
resolver
enst
ENSMUST00000027243
resolver
genesymbol
Il1r2
resolver
genesymbol_syn
Il-1r2
resolver
genesymbol_syn
Il1rb
resolver
uniprot
Q4FK69
resolver
uniprot_entry
IL1R2_MOUSE
resolver
uniprot_entry
Q4FK69_MOUSE
resolver
amino_acid_sequence
MFILLVLVTGVSAFTTPTVVHTGKVSESPITSEKPTVHGDNCQFRGREFKSELRLEGEPVVLRCPLAPHSDISSSSHSFLTWSKLDSSQLIPRDEPRMWVKGNILWILPAVQQDSGTYICTFRNASHCEQMSVELKVFKNTEASLPHVSYLQISALSTTGLLVCPDLKEFISSNADGKIQWYKGAILLDKGNKEFLSAGDPTRLLISNTSMDDAGYYRCVMTFTYNGQEYNITRNIELRVKGTTTEPIPVIISPLETIPASLGSRLIVPCKVFLGTGTSSNTIVWWLANSTFISAAYPRGRVTEGLHHQYSENDENYVEVSLIFDPVTREDLHTDFKCVASNPRSSQSLHTTVKEVSSTFSWSIALAPLSLIILVVGAIWMRRRCKRRAGKTYGLTKLRTDNQDFPSSPN
uniprot
proteins
function
FUNCTION: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity). {ECO:0000250, ECO:0000269|PubMed:8332913, ECO:0000269|PubMed:9662436}.
uniprot
proteins
mass_dalton
45645
uniprot
proteins
post_translational_modification
PTM: A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase. {ECO:0000250}.
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
15986350
uniprot
proteins
pubmed
16944957
uniprot
proteins
pubmed
1833184
uniprot
proteins
pubmed
8332913
uniprot
proteins
pubmed
9662436
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000250}. Secreted {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 356..381; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins