Map4k1
entrez
26411
canonical
uniprot
P70218
canonical
ensembl
ENSMUSG00000037337
resolver
ensp
ENSMUSP00000082995
resolver
ensp
ENSMUSP00000146807
resolver
ensp
ENSMUSP00000147189
resolver
ensp
ENSMUSP00000263958
resolver
ensp
ENSMUSP00000341086
resolver
ensp
ENSMUSP00000341087
resolver
enst
ENSMUST00000085835
resolver
enst
ENSMUST00000208227
resolver
genesymbol
Map4k1
resolver
genesymbol_syn
Hpk1
resolver
uniprot
A0A140LIG0
resolver
uniprot
Q3UPT4
resolver
uniprot
Q8R3R0
resolver
uniprot
Q99K62
resolver
uniprot_entry
A0A140LIG0_MOUSE
resolver
uniprot_entry
M4K1_MOUSE
resolver
uniprot_entry
Q3UPT4_MOUSE
resolver
uniprot_sec
Q8R3R0
resolver
uniprot_sec
Q99K62
resolver
amino_acid_sequence
MALVDPDIFNKDPREHYDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKMEPDDDVATLQKEILMLKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKMLSHQLVSQPGLNRGLILDLLDKMKNPGKGLPVDIEDEEPEPPPAIPRRIRSTYRASSLGIPDADCCRRQMEFQRPRCVDCRPQAETVRLYPPAHFGSTSPRSQLSDSDDDYDDVDIPAPSENIPPPLPPKPKFRSPSDDGSGGIRDDGQLSPGVLVRCASGPPPRTPRPGPPPATCSPHLTARSDPSLWNPAAPEPGQPPLVPPRKEKMRGKMENEKRREKYPLLVKLFNGCPLQIHSTAAWTHPSTKDQNLLLGAEEGIFILNRNDQEATLEMIFPGRTTWLYCINNLLMSLSGKTPYLYSHSILGLLERKDGRTGSPIAHISPHRLLARKNMVSSKIQDTKGCRACCVAESASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLPVFTLLTTPGSELPAVCIGVSPGQAAKSVLFHTVRFGALSCWLDDSSTEHKGPVQVIQVKEDMVMVLMDGSLKLVTPEGAPAPGLRTPEIPMTEAVEAVAMVEDRLEAFWKHGVQVWAPGLKQPLQELRDPTLTFRLLCSPRPVVVETRPTDDPTAPSNLYIQE
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase, which plays a role in the response to environmental stress (By similarity). Appears to act upstream of the JUN N-terminal pathway (PubMed:9003777). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (By similarity). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:9003777). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (PubMed:11509653). {ECO:0000250|UniProtKB:Q92918, ECO:0000269|PubMed:11509653, ECO:0000269|PubMed:9003777}.
uniprot
proteins
mass_dalton
91535
uniprot
proteins
mutagenesis
MUTAGEN 46; /note="K->E: Loss of kinase activity and ability to activate JNK family. Inhibits the ability of CLNK to up-regulate CD3-triggered activation of the IL2 promoter."; /evidence="ECO:0000269|PubMed:9003777
uniprot
proteins
post_translational_modification
PTM: Autophosphorylates: phosphorylation promotes ubiquitination by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex, leading to its degradation by the proteasome. {ECO:0000269|PubMed:9003777}.; PTM: Tyrosine-phosphorylated after activation of hemopoietic cells. {ECO:0000269|PubMed:11509653}.; PTM: Ubiquitinated by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex following autophosphorylation, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
11509653
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9003777
uniprot
proteins
sequence_length
827
uniprot
proteins