Gzmk
entrez
29165
canonical
uniprot
P49864
canonical
ensembl
ENSRNOG00000010661
resolver
ensp
ENSRNOP00000014319
resolver
genesymbol
Gzmk
resolver
uniprot_entry
GRAK_RAT
resolver
amino_acid_sequence
MSFSSSALVFLVAGIYMSSESFHTEIIGGREVQPHSRPFMASIQYRGKHICGGVLIHPQWVLTAAHCYSRGHSPTVVLGAHSLSKNEPMKQTFEIKEFIPFSGFKSGTNDIMLIKLRTAAELNKHVQLLHLRSKNYIRDGTKCQVTGWGSTKPDVLTTSDTLQEVTVTIISRKRCNSQSYYNHKPVITKDMICAGDRRGEKDSCKGDSGGPLICKGVFHALVSGGYKCGISNKPGVYTLLTKKYQTWIKSKLAPSSAH
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine protease that initiates the GZMK pathway of the complement system, a cascade of proteins directly activated by CD8(+) T-cells that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. GZMK is specifically secreted by CD8(+) T-cells and mediates both recognition and initiation steps of GZMK complement pathway. First acts as a pattern recognition receptor, which specifically recognizes and binds heparan sulfate glycosaminoglycans on the pathogen surface to drive opsonization. It then initiates the complement pathway cascade by catalyzing cleavage and activation of C2 and C4, the next components of the complement pathway. GZMK-mediated complement activation is an important contributor to tissue inflammation. Also able to cleave and activate F2R/PAR1 and PAR2/F2RL1, possibly promoting interleukin release. May also regulate apoptosis by catalyzing cleavage and activation of BID, thereby promoting cytochrome C release from mitochrondria. {ECO:0000250|UniProtKB:P49863}.
uniprot
proteins
mass_dalton
28465
uniprot
proteins
protein_family
Granzyme subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
8133042
uniprot
proteins
sequence_length
258
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P49863}. Cell surface {ECO:0000250|UniProtKB:P49863}. Cytoplasmic granule {ECO:0000250|UniProtKB:P49863}. Note=Constitutively secreted by CD8(+) T-cells in the absence of TCR stimulation. Specifically binds heparan sulfate glycosaminoglycans on the surface of pathogens. {ECO:0000250|UniProtKB:P49863}.
uniprot
proteins