LPXN
entrez
9404
canonical
uniprot
O60711
canonical
ensembl
ENSG00000110031
resolver
ensp
ENSP00000378512
resolver
ensp
ENSP00000431284
resolver
ensp
ENSP00000461855
resolver
ensp
ENSP00000655289
resolver
ensp
ENSP00000697982
resolver
enst
ENST00000528489
resolver
genesymbol
LPXN
resolver
genesymbol_syn
LDLP
resolver
hgnc
HGNC:14061
resolver
uniprot
B2R8B4
resolver
uniprot
B4DV71
resolver
uniprot
B7Z5P7
resolver
uniprot
I3NI37
resolver
uniprot
Q53FW6
resolver
uniprot
Q6FI07
resolver
uniprot_entry
B7Z5P7_HUMAN
resolver
uniprot_entry
I3NI37_HUMAN
resolver
uniprot_entry
LPXN_HUMAN
resolver
uniprot_sec
B2R8B4
resolver
uniprot_sec
B4DV71
resolver
uniprot_sec
Q53FW6
resolver
uniprot_sec
Q6FI07
resolver
amino_acid_sequence
MEELDALLEELERSTLQDSDEYSNPAPLPLDQHSRKETNLDETSEILSIQDNTSPLPAQLVYTTNIQELNVYSEAQEPKESPPPSKTSAAAQLDELMAHLTEMQAKVAVRADAGKKHLPDKQDHKASLDSMLGGLEQELQDLGIATVPKGHCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKLFPL
uniprot
proteins
function
FUNCTION: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}.
uniprot
proteins
mass_dalton
43332
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues. Phosphorylation on Tyr-72 is important for its inhibitory function. Bombesin stimulates phosphorylation on Tyr-22, Tyr-62 and Tyr-72. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:20543562}.
uniprot
proteins
protein_family
Paxillin family
uniprot
proteins
pubmed
10604475
uniprot
proteins
pubmed
12674328
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17329398
uniprot
proteins
pubmed
17640867
uniprot
proteins
pubmed
18451096
uniprot
proteins
pubmed
18497331
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20543562
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9565592
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B-cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin.
uniprot
proteins