RPUSD3
entrez
285367
canonical
uniprot
Q6P087
canonical
ensembl
ENSG00000156990
resolver
ensp
ENSP00000373331
resolver
ensp
ENSP00000398921
resolver
ensp
ENSP00000400397
resolver
ensp
ENSP00000408693
resolver
ensp
ENSP00000669914
resolver
enst
ENST00000424438
resolver
genesymbol
RPUSD3
resolver
hgnc
HGNC:28437
resolver
uniprot
B4DS39
resolver
uniprot
C9JM75
resolver
uniprot
Q6P6A9
resolver
uniprot
Q8N1B2
resolver
uniprot
Q8NAV3
resolver
uniprot_entry
C9JM75_HUMAN
resolver
uniprot_entry
RUSD3_HUMAN
resolver
uniprot_sec
B4DS39
resolver
uniprot_sec
Q6P6A9
resolver
uniprot_sec
Q8N1B2
resolver
uniprot_sec
Q8NAV3
resolver
amino_acid_sequence
MRAVLAREMDGRRVLGRFWSGWRRGLGVRPVPEDAGFGTEARHQRQPRGSCQRSGPLGDQPFAGLLPKNLSREELVDALRAAVVDRKGPLVTLNKPQGLPVTGKPGELTLFSVLPELSQSLGLREQELQVVRASGKESSGLVLLSSCPQTASRLQKYFTHARRAQRPTATYCAVTDGIPAASEGKIQAALKLEHIDGVNLTVPVKAPSRKDILEGVKKTLSHFRVVATGSGCALVQLQPLTVFSSQLQVHMVLQLCPVLGDHMYSARVGTVLGQRFLLPAENNKPQRQVLDEALLRRLHLTPSQAAQLPLHLHLHRLLLPGTRARDTPVELLAPLPPYFSRTLQCLGLRLQ
uniprot
proteins
ec_number
5.4.99.-
uniprot
proteins
function
FUNCTION: Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis (PubMed:27667664). {ECO:0000269|PubMed:27667664, ECO:0000269|PubMed:27974379}.
uniprot
proteins
mass_dalton
38461
uniprot
proteins
protein_family
Pseudouridine synthase RluA family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27667664
uniprot
proteins
pubmed
27974379
uniprot
proteins
pubmed
28082677
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:27974379}. Note=Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. {ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:28082677}.
uniprot
proteins