RCOR1
entrez
23186
canonical
uniprot
Q9UKL0
canonical
ensembl
ENSG00000089902
resolver
ensp
ENSP00000262241
resolver
enst
ENST00000262241
resolver
genesymbol
RCOR1
resolver
genesymbol_syn
KIAA0071
resolver
genesymbol_syn
RCOR
resolver
hgnc
HGNC:17441
resolver
uniprot
J3KN32
resolver
uniprot
Q15044
resolver
uniprot
Q6P2I9
resolver
uniprot
Q86VG5
resolver
uniprot_entry
RCOR1_HUMAN
resolver
uniprot_sec
J3KN32
resolver
uniprot_sec
Q15044
resolver
uniprot_sec
Q6P2I9
resolver
uniprot_sec
Q86VG5
resolver
amino_acid_sequence
MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVRYASAS
uniprot
proteins
function
FUNCTION: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}.
uniprot
proteins
mass_dalton
53327
uniprot
proteins
mutagenesis
MUTAGEN 106; /note="R->A: Reduces BCR(KBTBD4)-mediated proteasomal degradation."; /evidence="ECO:0000269|PubMed:36997086"; MUTAGEN 110; /note="Q->A: Reduces BCR(KBTBD4)-mediated proteasomal degradation."; /evidence="ECO:0000269|PubMed:36997086"; MUTAGEN 111; /note="Y->A: Reduces BCR(KBTBD4)-mediated proteasomal degradation."; /evidence="ECO:0000269|PubMed:36997086"; MUTAGEN 112; /note="Q->A: Reduces BCR(KBTBD4)-mediated proteasomal degradation."; /evidence="ECO:0000269|PubMed:36997086"; MUTAGEN 114; /note="V->A: Reduces BCR(KBTBD4)-mediated proteasomal degradation."; /evidence="ECO:0000269|PubMed:36997086"; MUTAGEN 117; /note="D->A: Reduces BCR(KBTBD4)-mediated proteasomal degradation."; /evidence="ECO:0000269|PubMed:36997086
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by HSV-1 protein kinases in case of infection. {ECO:0000269|PubMed:15897453}.
uniprot
proteins
protein_family
CoREST family
uniprot
proteins
pubmed
10449787
uniprot
proteins
pubmed
10734093
uniprot
proteins
pubmed
11102443
uniprot
proteins
pubmed
11171972
uniprot
proteins
pubmed
11516394
uniprot
proteins
pubmed
12032298
uniprot
proteins
pubmed
12192000
uniprot
proteins
pubmed
12399542
uniprot
proteins
pubmed
12493763
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15897453
uniprot
proteins
pubmed
16079794
uniprot
proteins
pubmed
16140033
uniprot
proteins
pubmed
16885027
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
36997086
uniprot
proteins
pubmed
7584044
uniprot
proteins
sequence_length
485
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:15897453}. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.
uniprot
proteins