Egln2
entrez
308457
canonical
uniprot
Q6AYU4
canonical
ensembl
ENSRNOG00000020947
resolver
ensembl
ENSRNOG00055033561
resolver
ensembl
ENSRNOG00060032226
resolver
ensembl
ENSRNOG00065033418
resolver
ensp
ENSRNOP00000028434
resolver
ensp
ENSRNOP00000081509
resolver
ensp
ENSRNOP00055047855
resolver
ensp
ENSRNOP00060046194
resolver
ensp
ENSRNOP00065047299
resolver
enst
ENSRNOT00000028434
resolver
enst
ENSRNOT00000116136
resolver
enst
ENSRNOT00055058015
resolver
enst
ENSRNOT00060055844
resolver
enst
ENSRNOT00065057458
resolver
genesymbol
Egln2
resolver
uniprot
A0A8I5ZS56
resolver
uniprot_entry
A0A8I5ZS56_RAT
resolver
uniprot_entry
EGLN2_RAT
resolver
amino_acid_sequence
MDSPCQPQALNQALPQLPGSVSESLEPSRARMGVESYLPCPLLPSYHRSGASGEASAGNGTPRTTATATTTTASPLREGFGGQDGGELWPLQSEGAAALVTKECQRLAAQGARPEAPKRKWAKDGGDAPSPSKRPWARQENQEAKGESGVGCDSGGGSSNSTTHSSGEASSRLREEAQPSAPERLALDYIVPCMRYYGICVKDNFLGAVLGGRVLAEVEALKWGGRLRDGQLVSQRAIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGNYVINGRTKAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDAKERAAARDKYQLASGQKGVQVPVSQPATPT
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
ec_number
1.14.11.29
uniprot
proteins
function
FUNCTION: Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:15925519). Target proteins are preferentially recognized via a LXXLAP motif (By similarity). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:15925519). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (By similarity). Also hydroxylates HIF2A (By similarity). Has a preference for the CODD site for both HIF1A and HIF2A (By similarity). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (By similarity). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (By similarity). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (By similarity). Also regulates susceptibility to normoxic oxidative neuronal death (By similarity). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (By similarity). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (By similarity). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). {ECO:0000250|UniProtKB:Q91YE2, ECO:0000250|UniProtKB:Q96KS0, ECO:0000269|PubMed:15925519}.
uniprot
proteins
mass_dalton
44681
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by SIAH1 and/or SIAH2 in response to the unfolded protein response (UPR), leading to its degradation. {ECO:0000250|UniProtKB:Q91YE2}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15925519
uniprot
proteins
pubmed
16765982
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16765982}.
uniprot
proteins