Slc7a2
entrez
11988
canonical
uniprot
P18581
canonical
ensembl
ENSMUSG00000031596
resolver
ensp
ENSMUSP00000058866
resolver
ensp
ENSMUSP00000096414
resolver
ensp
ENSMUSP00000298691
resolver
genesymbol
Slc7a2
resolver
genesymbol_syn
Atrc2
resolver
genesymbol_syn
Tea
resolver
uniprot
E9QPL9
resolver
uniprot
Q38RA6
resolver
uniprot
Q3TB99
resolver
uniprot
Q3U3R5
resolver
uniprot_entry
CTR2_MOUSE
resolver
uniprot_sec
E9QPL9
resolver
uniprot_sec
Q38RA6
resolver
uniprot_sec
Q3TB99
resolver
uniprot_sec
Q3U3R5
resolver
amino_acid_sequence
MIPCRAVLTFARCLIRRKIVTLDSLEDSKLCRCLTTVDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLNKQIGQFFKTYFKMNYTGLAEYPDFFAVCLVLLLAGLLSFGVKESAWVNKFFTAINILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVRWSPAKYVVSAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLARVSKRQSPVAATMTAGVISAVMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLCYDQPKYTPEKETLESCTNATLKSESQVTMLQGQGFSLRTLFSPSALPTRQSASLVSFLVGFLAFLILGLSILTTYGVQAIARLEAWSLALLALFLVLCVAVILTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWIRFSIWMALGFLIYFAYGIRHSLEGNPRDEEDDEDAFSDNINAATEEKSAMQANDHHQRNLSLPFILHEKTSEC
uniprot
proteins
function
FUNCTION: Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed:8195186, PubMed:8385111, PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport (PubMed:16670299). {ECO:0000269|PubMed:16670299, ECO:0000269|PubMed:8195186, ECO:0000269|PubMed:8385111, ECO:0000269|PubMed:9174363}.; FUNCTION: [Isoform 1]: Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). {ECO:0000269|PubMed:8195186, ECO:0000269|PubMed:9174363}.; FUNCTION: [Isoform 2]: Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). Shows a much higher affinity for L-arginine than isoform 1. {ECO:0000269|PubMed:8195186, ECO:0000269|PubMed:9174363}.
uniprot
proteins
mass_dalton
71856
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:8385111}.
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
protein_family
Cationic amino acid transporter (CAT) (TC 2.A.3.3) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16239143
uniprot
proteins
pubmed
16670299
uniprot
proteins
pubmed
1694015
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28642498
uniprot
proteins
pubmed
8195186
uniprot
proteins
pubmed
8385111
uniprot
proteins
pubmed
9174363
uniprot
proteins
sequence_length
657
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8195186, ECO:0000269|PubMed:8385111}; Multi-pass membrane protein {ECO:0000269|PubMed:8195186, ECO:0000269|PubMed:8385111}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..59; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 64..84; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 164..184; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 249..269; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 290..309; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 340..360; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 386..406; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 410..430; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 490..510; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 524..548; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 557..577; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 582..602; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins