LRRFIP2
entrez
9209
canonical
uniprot
Q9Y608
canonical
ensembl
ENSG00000093167
resolver
ensp
ENSP00000338727
resolver
ensp
ENSP00000346349
resolver
ensp
ENSP00000379705
resolver
ensp
ENSP00000405480
resolver
ensp
ENSP00000416364
resolver
ensp
ENSP00000570444
resolver
ensp
ENSP00000570445
resolver
ensp
ENSP00000570446
resolver
ensp
ENSP00000570447
resolver
ensp
ENSP00000570448
resolver
ensp
ENSP00000570454
resolver
ensp
ENSP00000570461
resolver
ensp
ENSP00000570466
resolver
ensp
ENSP00000570472
resolver
ensp
ENSP00000570482
resolver
ensp
ENSP00000570484
resolver
ensp
ENSP00000570486
resolver
ensp
ENSP00000570495
resolver
ensp
ENSP00000570507
resolver
ensp
ENSP00000622840
resolver
ensp
ENSP00000622842
resolver
ensp
ENSP00000622845
resolver
ensp
ENSP00000622882
resolver
ensp
ENSP00000622886
resolver
ensp
ENSP00000622892
resolver
ensp
ENSP00000622897
resolver
ensp
ENSP00000622903
resolver
ensp
ENSP00000622906
resolver
ensp
ENSP00000622910
resolver
ensp
ENSP00000622920
resolver
ensp
ENSP00000622933
resolver
ensp
ENSP00000622958
resolver
ensp
ENSP00000622974
resolver
ensp
ENSP00000623007
resolver
ensp
ENSP00000623011
resolver
ensp
ENSP00000716960
resolver
ensp
ENSP00000716964
resolver
genesymbol
LRRFIP2
resolver
hgnc
HGNC:6703
resolver
uniprot
A0A1S5UZ17
resolver
uniprot
A8K649
resolver
uniprot
A8MXR0
resolver
uniprot
B4DY63
resolver
uniprot
Q68CV3
resolver
uniprot
Q9NXH5
resolver
uniprot_entry
A0A1S5UZ17_HUMAN
resolver
uniprot_entry
LRRF2_HUMAN
resolver
uniprot_sec
A8K649
resolver
uniprot_sec
A8MXR0
resolver
uniprot_sec
B4DY63
resolver
uniprot_sec
Q68CV3
resolver
uniprot_sec
Q9NXH5
resolver
amino_acid_sequence
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEYSLHSFDRKWGQIQKWLEDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYDMFKDRSSRLSSLNHSYSHSHGMKKRSSDSHKDLLSGLYFDQRNYSSLRHSKPTSAYYTRQSSSLYSDPLATYKSDRASPTANSGLLRSASLASLYNGGLYNPYGPRTPSECSYYSSRISSARSSPGFTNDDTASIVSSDRASRGRRESVVSAADYFSRSNRRGSVVSEVDDISIPDLSSLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ
uniprot
proteins
function
FUNCTION: May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:15677333, ECO:0000269|PubMed:19265123}.
uniprot
proteins
mass_dalton
82171
uniprot
proteins
mutagenesis
MUTAGEN 190; /note="S->A: No change in LPS-induced NFKB activity."; /evidence="ECO:0000269|PubMed:21220426"; MUTAGEN 200; /note="S->A: No change in LPS-induced NFKB activity."; /evidence="ECO:0000269|PubMed:21220426"; MUTAGEN 202; /note="S->A: Reduction in LPS-induced NFKB activity."; /evidence="ECO:0000269|PubMed:21220426"; MUTAGEN 202; /note="S->E: No change in LPS-induced NFKB activity. Interacts with MYD88 in an LPS-inducible manner."; /evidence="ECO:0000269|PubMed:21220426
uniprot
proteins
post_translational_modification
PTM: Ser-190 and Ser-202 are phosphorylated in response to LPS stimulation. Ser-202 phosphorylation regulates the LPS-induced interaction with MYD88. {ECO:0000269|PubMed:21220426}.
uniprot
proteins
protein_family
LRRFIP family
uniprot
proteins
pubmed
10366446
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15677333
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17693683
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19265123
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21220426
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
721
uniprot
proteins