Cav3
entrez
12391
canonical
uniprot
P51637
canonical
ensembl
ENSMUSG00000062694
resolver
ensp
ENSMUSP00000074922
resolver
enst
ENSMUST00000075477
resolver
genesymbol
Cav3
resolver
uniprot_entry
CAV3_MOUSE
resolver
amino_acid_sequence
MMTEEHTDLEARIIKDIHCKEIDLVNRDPKNINEDIVKVDFEDVIAEPEGTYSFDGVWKVSFTTFTVSKYWCYRLLSTLLGVPLALLWGFLFACISFCHIWAVVPCIKSYLIEIQCISHIYSLCIRTFCNPLFAALGQVCSNIKVVLRREG
uniprot
proteins
function
FUNCTION: May act as a scaffolding protein within caveolar membranes. Interacts directly with G protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (PubMed:19380584). Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (By similarity). {ECO:0000250|UniProtKB:P56539, ECO:0000269|PubMed:19380584}.
uniprot
proteins
mass_dalton
17358
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="R->Q: Results in aberrent localization of TRIM72 and defects in membrane repair."; /evidence="ECO:0000269|PubMed:19380584"; MUTAGEN 105; /note="P->L: Dominant-negative mutant that induces defects in membrane repair."; /evidence="ECO:0000269|PubMed:19380584
uniprot
proteins
post_translational_modification
PTM: Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2. {ECO:0000250}.
uniprot
proteins
protein_family
Caveolin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19380584
uniprot
proteins
pubmed
19940021
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24066022
uniprot
proteins
pubmed
26497963
uniprot
proteins
pubmed
8521953
uniprot
proteins
pubmed
8549793
uniprot
proteins
sequence_length
151
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:26497963}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000269|PubMed:24066022}; Peripheral membrane protein {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000269|PubMed:24066022}. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). {ECO:0000250}.
uniprot
proteins