Irak3
entrez
73914
canonical
uniprot
Q8K4B2
canonical
ensembl
ENSMUSG00000020227
resolver
ensp
ENSMUSP00000020448
resolver
ensp
ENSMUSP00000118038
resolver
enst
ENSMUST00000020448
resolver
enst
ENSMUST00000145665
resolver
genesymbol
Irak3
resolver
uniprot
D3Z007
resolver
uniprot
Q0VB14
resolver
uniprot
Q8C7U8
resolver
uniprot
Q8CE40
resolver
uniprot
Q8K1S8
resolver
uniprot_entry
D3Z007_MOUSE
resolver
uniprot_entry
IRAK3_MOUSE
resolver
uniprot_entry
Q0VB14_MOUSE
resolver
uniprot_sec
Q8C7U8
resolver
uniprot_sec
Q8CE40
resolver
uniprot_sec
Q8K1S8
resolver
amino_acid_sequence
MAGRCGARGALSPQLLLFDLPPALLGELCGILDSCDGPLGWRGLAERLSNSWLDVRHIEKYVNQGKSGTRELLWSWAQKNKTIGDLLEVLQDMGHQRAIHLIINYGVSWTPSVQTHHELPFPSFPPEVKHACRENDPGPLEPANVTVDNVLVPEHNEKGTLQKTPISFQSILEGTKHFHKDFLIGEGEIFEVYRVDIRNQAYAVKLFKQEKKMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGTTPLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPNLEQQSSTINMTGGGRKHLWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTGCKVVLDDPKHVQLRDLLMELMEKRGLDSCLSFLDRKIPPCPRNFSAKLFSLAGRCVATKAKLRPTMDEVLSSLESTQPSLYFAEDPPTSLKSFRCPSPLFLDNVPSIPVEDDENQNNHSVPPKEVLGTDRVTQKTPFECSQSEVTFLGLDRNRGNRGSEADCNVPSSSHEECWSPELVAPSQDLSPTVISLGSSWEVPGHSYGSKPMEKRCSSGLFCSEHEQSKKQ
uniprot
proteins
function
FUNCTION: Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:12054681, PubMed:12150927, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (PubMed:12054681, PubMed:12150927). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383). {ECO:0000269|PubMed:12054681, ECO:0000269|PubMed:12150927, ECO:0000269|PubMed:29686383}.
uniprot
proteins
mass_dalton
68455
uniprot
proteins
protein_family
Pelle subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
12054681
uniprot
proteins
pubmed
12150927
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
29686383
uniprot
proteins
sequence_length
609
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29686383}. Nucleus {ECO:0000269|PubMed:29686383}. Note=In dendritic cells, translocates into the nucleus upon IL33 stimulation. {ECO:0000269|PubMed:29686383}.
uniprot
proteins