Tlr6
entrez
21899
canonical
uniprot
Q9EPW9
canonical
ensembl
ENSMUSG00000051498
resolver
ensp
ENSMUSP00000062096
resolver
ensp
ENSMUSP00000159286
resolver
ensp
ENSMUSP00000281804
resolver
ensp
ENSMUSP00000281805
resolver
ensp
ENSMUSP00000281806
resolver
enst
ENSMUST00000062315
resolver
enst
ENSMUST00000239485
resolver
genesymbol
Tlr6
resolver
uniprot
A0A6I8MWV9
resolver
uniprot
Q3UV88
resolver
uniprot
Q9WTQ4
resolver
uniprot_entry
A0A6I8MWV9_MOUSE
resolver
uniprot_entry
Q3UV88_MOUSE
resolver
uniprot_entry
TLR6_MOUSE
resolver
uniprot_sec
Q9WTQ4
resolver
amino_acid_sequence
MSQDRKPIVGSFHFVCALALIVGSMTPFSNELESMVDYSNRNLTHVPKDLPPRTKALSLSQNSISELRMPDISFLSELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQNISCCPMASLRHLDLSFNDFDVLPVCKEFGNLTKLTFLGLSAAKFRQLDLLPVAHLHLSCILLDLVSYHIKGGETESLQIPNTTVLHLVFHPNSLFSVQVNMSVNALGHLQLSNIKLNDENCQRLMTFLSELTRGPTLLNVTLQHIETTWKCSVKLFQFFWPRPVEYLNIYNLTITERIDREEFTYSETALKSLMIEHVKNQVFLFSKEALYSVFAEMNIKMLSISDTPFIHMVCPPSPSSFTFLNFTQNVFTDSVFQGCSTLKRLQTLILQRNGLKNFFKVALMTKNMSSLETLDVSLNSLNSHAYDRTCAWAESILVLNLSSNMLTGSVFRCLPPKVKVLDLHNNRIMSIPKDVTHLQALQELNVASNSLTDLPGCGAFSSLSVLVIDHNSVSHPSEDFFQSCQNIRSLTAGNNPFQCTCELRDFVKNIGWVAREVVEGWPDSYRCDYPESSKGTALRDFHMSPLSCDTVLLTVTIGATMLVLAVTGAFLCLYFDLPWYVRMLCQWTQTRHRARHIPLEELQRNLQFHAFVSYSEHDSAWVKNELLPNLEKDDIRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPILQNNIPSRYHKLRALMAQRTYLEWPTEKGKRGLFWANLRASFIMKLALVNEDDVKT
uniprot
proteins
function
FUNCTION: Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:19931471). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion (PubMed:20037584, PubMed:23812099). {ECO:0000269|PubMed:19931471, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:23812099}.
uniprot
proteins
mass_dalton
91116
uniprot
proteins
mutagenesis
MUTAGEN 680; /note="P->H: Dominant negative mutant, blocks response to Gram-positive pathogens."; /evidence="ECO:0000269|PubMed:11095740
uniprot
proteins
protein_family
Toll-like receptor family
uniprot
proteins
pubmed
10231569
uniprot
proteins
pubmed
11095740
uniprot
proteins
pubmed
19931471
uniprot
proteins
pubmed
20037584
uniprot
proteins
pubmed
23812099
uniprot
proteins
sequence_length
795
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11095740}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:11095740}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000250|UniProtKB:Q9Y2C9}. Golgi apparatus {ECO:0000250|UniProtKB:Q9Y2C9}. Note=Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis. Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. {ECO:0000250|UniProtKB:Q9Y2C9}.
uniprot
proteins
transmembrane_region
TRANSMEM 585..605; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins