Bace2
entrez
56175
canonical
uniprot
Q9JL18
canonical
ensembl
ENSMUSG00000040605
resolver
ensp
ENSMUSP00000043918
resolver
enst
ENSMUST00000047275
resolver
genesymbol
Bace2
resolver
uniprot
A0A0R4J0I8
resolver
uniprot
Q3TNS7
resolver
uniprot
Q8C5E9
resolver
uniprot
Q8C793
resolver
uniprot
Q9R1P7
resolver
uniprot_entry
A0A0R4J0I8_MOUSE
resolver
uniprot_entry
BACE2_MOUSE
resolver
uniprot_sec
Q3TNS7
resolver
uniprot_sec
Q8C5E9
resolver
uniprot_sec
Q8C793
resolver
uniprot_sec
Q9R1P7
resolver
amino_acid_sequence
MGALLRALLLLVLAQWLLSAVPALAPAPFTLPLQVAGATNHRASAVPGLGTPELPRADGLALALEPVRATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVQILVDTGSSNFAVAGAPHSYIDTYFDSESSSTYHSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESENFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQNLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQRRVGFAVSPCAEIEGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILLVLILLLLLPLHCRHAPRDPEVVNDESSLVRHRWK
uniprot
proteins
ec_number
3.4.23.45
uniprot
proteins
function
FUNCTION: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells. {ECO:0000250|UniProtKB:Q9Y5Z0}.
uniprot
proteins
mass_dalton
55800
uniprot
proteins
post_translational_modification
PTM: Undergoes autoproteolytic cleavage. {ECO:0000250|UniProtKB:Q9Y5Z0}.; PTM: Glycosylated. {ECO:0000250|UniProtKB:Q9Y5Z0}.
uniprot
proteins
protein_family
Peptidase A1 family
uniprot
proteins
pubmed
10683441
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21907142
uniprot
proteins
pubmed
23754390
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21907142}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus {ECO:0000250|UniProtKB:Q9Y5Z0}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9Y5Z0}. Endosome {ECO:0000250|UniProtKB:Q9Y5Z0}. Melanosome {ECO:0000250|UniProtKB:Q9Y5Z0}. Note=Colocalizes with PMEL in stage I and II melanosomes. {ECO:0000250|UniProtKB:Q9Y5Z0}.
uniprot
proteins
transmembrane_region
TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins