Map2k2
entrez
58960
canonical
uniprot
P36506
canonical
ensembl
ENSRNOG00000020005
resolver
ensp
ENSRNOP00000027272
resolver
ensp
ENSRNOP00000085974
resolver
enst
ENSRNOT00000027272
resolver
genesymbol
Map2k2
resolver
genesymbol_syn
Mek2
resolver
genesymbol_syn
Mkk2
resolver
genesymbol_syn
Prkmk2
resolver
uniprot
A0A8L2QEI7
resolver
uniprot
A0JN15
resolver
uniprot_entry
A0A8L2QEI7_RAT
resolver
uniprot_entry
MP2K2_RAT
resolver
uniprot_sec
A0JN15
resolver
amino_acid_sequence
MLARRKPVLPALTINPTIAEGPSPTSEGASEAHLVDLQKKLEELDLDEQQRKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRPPGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLTNHAFIKRSEGEDVDFAGWLCRTLRLKQPSTPTRTAV
uniprot
proteins
ec_number
2.7.12.2
uniprot
proteins
function
FUNCTION: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). {ECO:0000250|UniProtKB:P36507, ECO:0000250|UniProtKB:Q63932}.
uniprot
proteins
mass_dalton
44282
uniprot
proteins
post_translational_modification
PTM: MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
MAP kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8393135
uniprot
proteins
pubmed
8397117
uniprot
proteins
pubmed
8462694
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P36507}. Membrane {ECO:0000250|UniProtKB:P36507}; Peripheral membrane protein {ECO:0000250|UniProtKB:P36507}. Note=Membrane localization is probably regulated by its interaction with KSR1. {ECO:0000250|UniProtKB:P36507}.
uniprot
proteins