NANOS2
entrez
339345
canonical
uniprot
P60321
canonical
ensembl
ENSG00000188425
resolver
ensp
ENSP00000341021
resolver
enst
ENST00000341294
resolver
genesymbol
NANOS2
resolver
genesymbol_syn
NOS2
resolver
hgnc
HGNC:23292
resolver
uniprot
Q17R30
resolver
uniprot
Q4G0P8
resolver
uniprot_entry
NANO2_HUMAN
resolver
uniprot_sec
Q17R30
resolver
uniprot_sec
Q4G0P8
resolver
amino_acid_sequence
MQLPPFDMWKDYFNLSQVVWALIASRGQRLETQEIEEPSPGPPLGQDQGLGAPGANGGLGTLCNFCKHNGESRHVYSSHQLKTPDGVVVCPILRHYVCPVCGATGDQAHTLKYCPLNGGQQSLYRRSGRNSAGRRVKR
uniprot
proteins
function
FUNCTION: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
15132
uniprot
proteins
protein_family
Nanos family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19168545
uniprot
proteins
pubmed
21421998
uniprot
proteins
sequence_length
138
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19168545}. Cytoplasm, P-body {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19168545}. Note=Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis. {ECO:0000250}.
uniprot
proteins