CRH
entrez
1392
canonical
uniprot
P06850
canonical
ensembl
ENSG00000147571
resolver
ensp
ENSP00000276571
resolver
ensp
ENSP00000618684
resolver
enst
ENST00000276571
resolver
enst
ENST00000948625
resolver
genesymbol
CRH
resolver
hgnc
HGNC:2355
resolver
uniprot
A0A0S2Z478
resolver
uniprot
B3KQS4
resolver
uniprot_entry
A0A0S2Z478_HUMAN
resolver
uniprot_entry
CRH_HUMAN
resolver
uniprot_sec
B3KQS4
resolver
activity_regulation
ACTIVITY REGULATION: Specifically inhibited by CRHBP, which prevents binding to CRH receptors CRHR1 and CRHR2. {ECO:0000269|PubMed:18234674, ECO:0000269|PubMed:1846945}.
uniprot
proteins
amino_acid_sequence
MRLPLLVSAGVLLVALLPCPPCRALLSRGPVPGARQAPQHPQPLDFFQPPPQSEQPQQPQARPVLLRMGEEYFLRLGNLNKSPAAPLSPASSLLAGGSGSRPSPEQATANFFRVLLQQLLLPRRSLDSPAALAERGARNALGGHQEAPERERRSEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK
uniprot
proteins
function
FUNCTION: Hormone that plays a central role in whole body adaptation to stress (By similarity). Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptor CRHR1, and to a lower extent, CRHR2 (PubMed:18801728, PubMed:3003585, PubMed:32004469). CRH-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (By similarity). Acts as a 'placental clock' during pregnancy, regulating gestational length, fetal development and the timing of labor (PubMed:7585095). Also acts as a regulator of blastocyst implantation by promoting decidualization, regulating trophoblast invasion and facilitating maternal immune tolerance (PubMed:11590404). {ECO:0000250|UniProtKB:Q8CIT0, ECO:0000269|PubMed:11590404, ECO:0000269|PubMed:18801728, ECO:0000269|PubMed:3003585, ECO:0000269|PubMed:32004469, ECO:0000269|PubMed:7585095}.
uniprot
proteins
mass_dalton
21422
uniprot
proteins
mutagenesis
MUTAGEN 183; /note="Q->A: Strongly reduced affinity for CRFR1."; /evidence="ECO:0000269|PubMed:18801728"; MUTAGEN 187; /note="N->A: No effect on affinity for CRFR1."; /evidence="ECO:0000269|PubMed:18801728"; MUTAGEN 188; /note="R->A: Strongly reduced affinity for CRFR1."; /evidence="ECO:0000269|PubMed:18801728"; MUTAGEN 190; /note="L->A: Strongly reduced affinity for CRFR1."; /evidence="ECO:0000269|PubMed:18801728"; MUTAGEN 191; /note="M->A: Strongly reduced affinity for CRFR1."; /evidence="ECO:0000269|PubMed:18801728"; MUTAGEN 192; /note="E->A: No effect on affinity for CRFR1."; /evidence="ECO:0000269|PubMed:18801728
uniprot
proteins
post_translational_modification
PTM: The precursor protein is cleaved into corticotropin-releasing hormone (CRH) by neuroendocrine convertases PCSK2 (PubMed:8879041). It is then amidated at the C-terminus, completing its activation (Probable). {ECO:0000269|PubMed:8879041, ECO:0000305|PubMed:6605851}.
uniprot
proteins
protein_family
Sauvagine/corticotropin-releasing factor/urotensin I family
uniprot
proteins
pubmed
11590404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
18234674
uniprot
proteins
pubmed
1846945
uniprot
proteins
pubmed
18559919
uniprot
proteins
pubmed
18801728
uniprot
proteins
pubmed
23593457
uniprot
proteins
pubmed
2783917
uniprot
proteins
pubmed
2839838
uniprot
proteins
pubmed
3003585
uniprot
proteins
pubmed
32004469
uniprot
proteins
pubmed
3262120
uniprot
proteins
pubmed
6605851
uniprot
proteins
pubmed
7585095
uniprot
proteins
pubmed
8386360
uniprot
proteins
pubmed
8879041
uniprot
proteins
sequence_length
196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18559919, ECO:0000269|PubMed:2839838}.
uniprot
proteins