NRG1
entrez
3084
canonical
uniprot
Q02297
canonical
ensembl
ENSG00000157168
resolver
ensp
ENSP00000287842
resolver
ensp
ENSP00000349275
resolver
ensp
ENSP00000384620
resolver
ensp
ENSP00000428828
resolver
ensp
ENSP00000429067
resolver
ensp
ENSP00000429582
resolver
ensp
ENSP00000430120
resolver
ensp
ENSP00000430862
resolver
ensp
ENSP00000433289
resolver
ensp
ENSP00000434640
resolver
ensp
ENSP00000498583
resolver
ensp
ENSP00000498590
resolver
ensp
ENSP00000498646
resolver
ensp
ENSP00000498811
resolver
ensp
ENSP00000498833
resolver
ensp
ENSP00000498946
resolver
ensp
ENSP00000499008
resolver
ensp
ENSP00000499045
resolver
ensp
ENSP00000613735
resolver
enst
ENST00000522402
resolver
enst
ENST00000650819
resolver
enst
ENST00000650866
resolver
enst
ENST00000650967
resolver
enst
ENST00000650980
resolver
enst
ENST00000651333
resolver
enst
ENST00000652592
resolver
enst
ENST00000652698
resolver
genesymbol
NRG1
resolver
genesymbol_syn
GGF
resolver
genesymbol_syn
HGL
resolver
genesymbol_syn
HRGA
resolver
genesymbol_syn
NDF
resolver
genesymbol_syn
SMDF
resolver
hgnc
HGNC:7997
resolver
uniprot
A0A024QY88
resolver
uniprot
A0A494C0K4
resolver
uniprot
A0A494C0L9
resolver
uniprot
A0A494C0Q4
resolver
uniprot
A0A494C114
resolver
uniprot
A0A494C1B5
resolver
uniprot
A0A494C1F5
resolver
uniprot
A0A494C1F8
resolver
uniprot
A5YAK4
resolver
uniprot
A5YAK5
resolver
uniprot
A5YAK6
resolver
uniprot
A5YAK8
resolver
uniprot
A6MW54
resolver
uniprot
A6MW55
resolver
uniprot
A6MW56
resolver
uniprot
A8K1L2
resolver
uniprot
B0FWZ3
resolver
uniprot
B0FYA7
resolver
uniprot
B0FYA8
resolver
uniprot
B0FYA9
resolver
uniprot
B7Z1D7
resolver
uniprot
B7Z1E3
resolver
uniprot
B7Z4Z3
resolver
uniprot
E3SFM9
resolver
uniprot
E5RHP6
resolver
uniprot
E9PHH4
resolver
uniprot
O14667
resolver
uniprot
P98202
resolver
uniprot
Q02298
resolver
uniprot
Q02299
resolver
uniprot
Q07110
resolver
uniprot
Q07111
resolver
uniprot
Q12779
resolver
uniprot
Q12780
resolver
uniprot
Q12781
resolver
uniprot
Q12782
resolver
uniprot
Q12783
resolver
uniprot
Q12784
resolver
uniprot
Q15491
resolver
uniprot
Q6PK61
resolver
uniprot
Q7RTV9
resolver
uniprot
Q7RTW0
resolver
uniprot
Q7RTW1
resolver
uniprot
Q7RTW2
resolver
uniprot
Q7RTW3
resolver
uniprot
Q7RTW5
resolver
uniprot
Q8NFN1
resolver
uniprot
Q8NFN2
resolver
uniprot
Q8NFN3
resolver
uniprot
Q9UPE3
resolver
uniprot_entry
A0A024QY88_HUMAN
resolver
uniprot_entry
A0A494C0K4_HUMAN
resolver
uniprot_entry
A0A494C0L9_HUMAN
resolver
uniprot_entry
A0A494C0Q4_HUMAN
resolver
uniprot_entry
A0A494C114_HUMAN
resolver
uniprot_entry
A0A494C1B5_HUMAN
resolver
uniprot_entry
A0A494C1F5_HUMAN
resolver
uniprot_entry
A0A494C1F8_HUMAN
resolver
uniprot_entry
A5YAK6_HUMAN
resolver
uniprot_entry
A5YAK8_HUMAN
resolver
uniprot_entry
A6MW54_HUMAN
resolver
uniprot_entry
A6MW55_HUMAN
resolver
uniprot_entry
A6MW56_HUMAN
resolver
uniprot_entry
B0FWZ3_HUMAN
resolver
uniprot_entry
B0FYA7_HUMAN
resolver
uniprot_entry
B0FYA8_HUMAN
resolver
uniprot_entry
B0FYA9_HUMAN
resolver
uniprot_entry
B7Z1D7_HUMAN
resolver
uniprot_entry
B7Z1E3_HUMAN
resolver
uniprot_entry
E3SFM9_HUMAN
resolver
uniprot_entry
E5RHP6_HUMAN
resolver
uniprot_entry
NRG1_HUMAN
resolver
uniprot_entry
Q6PK61_HUMAN
resolver
uniprot_entry
Q7RTW3_HUMAN
resolver
uniprot_entry
Q7RTW5_HUMAN
resolver
uniprot_sec
A5YAK4
resolver
uniprot_sec
A5YAK5
resolver
uniprot_sec
A8K1L2
resolver
uniprot_sec
B7Z4Z3
resolver
uniprot_sec
E9PHH4
resolver
uniprot_sec
O14667
resolver
uniprot_sec
P98202
resolver
uniprot_sec
Q02298
resolver
uniprot_sec
Q02299
resolver
uniprot_sec
Q07110
resolver
uniprot_sec
Q07111
resolver
uniprot_sec
Q12779
resolver
uniprot_sec
Q12780
resolver
uniprot_sec
Q12781
resolver
uniprot_sec
Q12782
resolver
uniprot_sec
Q12783
resolver
uniprot_sec
Q12784
resolver
uniprot_sec
Q15491
resolver
uniprot_sec
Q7RTV9
resolver
uniprot_sec
Q7RTW0
resolver
uniprot_sec
Q7RTW1
resolver
uniprot_sec
Q7RTW2
resolver
uniprot_sec
Q8NFN1
resolver
uniprot_sec
Q8NFN2
resolver
uniprot_sec
Q8NFN3
resolver
uniprot_sec
Q9UPE3
resolver
amino_acid_sequence
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving NRG1 produces gamma-heregulin. Translocation t(8;11) with TENM4. The translocation fuses the 5'-end of TENM4 to NRG1 (isoform 8). The product of this translocation was first thought to be an alternatively spliced isoform. Gamma-heregulin is a soluble activating ligand for the ERBB2-ERBB3 receptor complex and acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175). Not detected in breast carcinoma samples, including ductal, lobular, medullary, and mucinous histological types, neither in other breast cancer cell lines.
uniprot
proteins
function
FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250|UniProtKB:P43322, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:7902537}.
uniprot
proteins
mass_dalton
70392
uniprot
proteins
mutagenesis
MUTAGEN 181; /note="K->E: Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-185 or E-187. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-185 and E-187."; /evidence="ECO:0000269|PubMed:20682778"; MUTAGEN 185; /note="K->E: Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-181 or E-187. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-181 and E-187."; /evidence="ECO:0000269|PubMed:20682778"; MUTAGEN 187; /note="K->E: Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-181 or E-185. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-181 and E-185."; /evidence="ECO:0000269|PubMed:20682778
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.; PTM: N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Neuregulin family
uniprot
proteins
pubmed
10523851
uniprot
proteins
pubmed
10597312
uniprot
proteins
pubmed
10867024
uniprot
proteins
pubmed
12145742
uniprot
proteins
pubmed
1348215
uniprot
proteins
pubmed
1350381
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17565985
uniprot
proteins
pubmed
20682778
uniprot
proteins
pubmed
7509448
uniprot
proteins
pubmed
7689552
uniprot
proteins
pubmed
7782315
uniprot
proteins
pubmed
7902537
uniprot
proteins
pubmed
8062828
uniprot
proteins
pubmed
8096067
uniprot
proteins
pubmed
8639490
uniprot
proteins
pubmed
9333014
uniprot
proteins
sequence_length
640
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Pro-neuregulin-1, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active.; SUBCELLULAR LOCATION: [Neuregulin-1]: Secreted.; SUBCELLULAR LOCATION: [Isoform 8]: Nucleus. Note=May be nuclear.; SUBCELLULAR LOCATION: [Isoform 9]: Secreted. Note=Has a signal peptide.; SUBCELLULAR LOCATION: [Isoform 10]: Membrane; Single-pass type I membrane protein. Note=May possess an internal uncleaved signal sequence.
uniprot
proteins
transmembrane_region
TRANSMEM 243..265; /note="Helical; Note=Internal signal sequence"; /evidence="ECO:0000255
uniprot
proteins