IGFBP7
entrez
3490
canonical
uniprot
Q16270
canonical
ensembl
ENSG00000163453
resolver
ensp
ENSP00000295666
resolver
ensp
ENSP00000486293
resolver
genesymbol
IGFBP7
resolver
genesymbol_syn
MAC25
resolver
genesymbol_syn
PSF
resolver
hgnc
HGNC:5476
resolver
uniprot
B4E1N2
resolver
uniprot
B7Z9W7
resolver
uniprot
Q07822
resolver
uniprot
Q53YE6
resolver
uniprot
Q9UCA8
resolver
uniprot_entry
IBP7_HUMAN
resolver
uniprot_sec
B4E1N2
resolver
uniprot_sec
B7Z9W7
resolver
uniprot_sec
Q07822
resolver
uniprot_sec
Q53YE6
resolver
uniprot_sec
Q9UCA8
resolver
amino_acid_sequence
MERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCAPGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVVDALHEIPVKKGEGAEL
uniprot
proteins
disease_involvement
DISEASE: Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) [MIM:614224]: An autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. {ECO:0000269|PubMed:21835307}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Acts as a ligand for CD93 to play a role in angiogenesis (PubMed:38218180). {ECO:0000269|PubMed:8117260, ECO:0000269|PubMed:8939990}.
uniprot
proteins
mass_dalton
29130
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:8939990}.
uniprot
proteins
pubmed
11549700
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18772245
uniprot
proteins
pubmed
21835307
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
38218180
uniprot
proteins
pubmed
7694637
uniprot
proteins
pubmed
7980422
uniprot
proteins
pubmed
8117260
uniprot
proteins
pubmed
8939990
uniprot
proteins
sequence_length
282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins