Slc25a47
entrez
104910
canonical
uniprot
Q6IS41
canonical
ensembl
ENSMUSG00000048856
resolver
ensp
ENSMUSP00000050329
resolver
enst
ENSMUST00000057026
resolver
genesymbol
Slc25a47
resolver
genesymbol_syn
Hdmcp
resolver
uniprot
Q3UES2
resolver
uniprot
Q5FW58
resolver
uniprot
Q7TPP3
resolver
uniprot_entry
S2547_MOUSE
resolver
uniprot_sec
Q3UES2
resolver
uniprot_sec
Q5FW58
resolver
uniprot_sec
Q7TPP3
resolver
amino_acid_sequence
MDFVAGAIGGVCGVAVGYPLDTVKVRIQTEAKYAGIWHCIRDTYRQERVWGFYRGLSLPVCTVSLVSSVSFGTYHHCLAHICRFRYGSTDAKPTKADITLSGCASGLVRVFLTSPTEVAKVRLQTQTQAQTQQRRSSASWTSGAPALCPTPTACLEPRPKYSGPLHCLVTVAREEGLRGLYKGSSALLLREGHSFATYFLSYAMLCEWLTPAGHSQPDVLGVLVAGGCAGVLAWAVATPMDVIKSRLQADGQGQHRYRGLLHCVVTSVREEGPRVLFKGLALNCCRAFPVNMVVFVAYEAVLRLTQSLLT
uniprot
proteins
function
FUNCTION: Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated. {ECO:0000269|PubMed:36804859}.
uniprot
proteins
mass_dalton
33646
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
36804859
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:36804859}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000269|PubMed:36804859}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 3..23; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 55..75; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 98..114; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 194..210; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 280..298; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins