Adra2c
entrez
11553
canonical
uniprot
Q01337
canonical
ensembl
ENSMUSG00000045318
resolver
ensp
ENSMUSP00000059705
resolver
enst
ENSMUST00000049545
resolver
genesymbol
Adra2c
resolver
uniprot_entry
ADA2C_MOUSE
resolver
amino_acid_sequence
MASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWVPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRGPAGPDGASPTTENGLGKAAGENGHCAPPRTEVEPDESSAAERRRRRGALRRGGRRREGAEGDTGSADGPGPGLAAEQGARTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
uniprot
proteins
function
FUNCTION: Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (By similarity). ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity (PubMed:10647009). {ECO:0000250|UniProtKB:P08913, ECO:0000269|PubMed:10647009}.
uniprot
proteins
mass_dalton
49906
uniprot
proteins
protein_family
ADRA2C sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10647009
uniprot
proteins
pubmed
1353249
uniprot
proteins
pubmed
8387367
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18825}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..74; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P18825"; TRANSMEM 88..110; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P18825"; TRANSMEM 122..147; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P18825"; TRANSMEM 168..187; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P18825"; TRANSMEM 209..231; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P18825"; TRANSMEM 380..404; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P18825"; TRANSMEM 413..436; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P18825
uniprot
proteins