L3MBTL3
entrez
84456
canonical
uniprot
Q96JM7
canonical
ensembl
ENSG00000198945
resolver
ensp
ENSP00000354526
resolver
ensp
ENSP00000357118
resolver
ensp
ENSP00000436706
resolver
ensp
ENSP00000437185
resolver
ensp
ENSP00000528983
resolver
ensp
ENSP00000528984
resolver
ensp
ENSP00000528985
resolver
ensp
ENSP00000528986
resolver
ensp
ENSP00000528989
resolver
ensp
ENSP00000528990
resolver
ensp
ENSP00000636195
resolver
genesymbol
L3MBTL3
resolver
genesymbol_syn
KIAA1798
resolver
genesymbol_syn
MBT1
resolver
hgnc
HGNC:23035
resolver
uniprot
Q4VXE1
resolver
uniprot
Q5VUM9
resolver
uniprot
Q6P9B5
resolver
uniprot_entry
LMBL3_HUMAN
resolver
uniprot_sec
Q4VXE1
resolver
uniprot_sec
Q5VUM9
resolver
uniprot_sec
Q6P9B5
resolver
amino_acid_sequence
MTESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALEVITDENEMENVKKATATTTWMVPTAQEAPTSPPSSRPVFPPAYWTSPPGCPTVFSEKTGMPFRLKDPVKVEGLQFCENCCQYGNVDECLSGGNYCSQNCARHIKDKDQKEERDVEEDNEEEDPKCSRKKKPKLSLKADTKEDGEERDDEMENKQDVRILRGSQRARRKRRGDSAVLKQGLPPKGKKAWCWASYLEEEKAVAVPAKLFKEHQSFPYNKNGFKVGMKLEGVDPEHQSVYCVLTVAEVCGYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLHPPKGYKEEEFNWQTYLKTCKAQAAPKSLFENQNITVIPSGFRVGMKLEAVDKKNPSFICVATVTDMVDNRFLVHFDNWDESYDYWCEASSPHIHPVGWCKEHRRTLITPPGYPNVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMKLEVVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSKTGHPLQPPLSPLELMEASEHGGCSTPGCKGIGHFKRARHLGPHSAANCPYSEINLNKDRIFPDRLSGEMPPASPSFPRNKRTDANESSSSPEIRDQHADDVKEDFEERTESEMRTSHEARGAREEPTVQQAQRRSAVFLSFKSPIPCLPLRWEQQSKLLPTVAGIPASKVSKWSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAAEKNSHNEL
uniprot
proteins
function
FUNCTION: Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:29691401, PubMed:30442713). Required for normal maturation of myeloid progenitor cells (By similarity). {ECO:0000250|UniProtKB:Q8BLB7, ECO:0000269|PubMed:29030483, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}.
uniprot
proteins
mass_dalton
88337
uniprot
proteins
mutagenesis
MUTAGEN 381; /note="D->N: Loss of interaction with DNMT1."; /evidence="ECO:0000269|PubMed:29691401
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29030483
uniprot
proteins
pubmed
29691401
uniprot
proteins
pubmed
30442713
uniprot
proteins
pubmed
33980486
uniprot
proteins
sequence_length
780
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33980486}.
uniprot
proteins