C1QTNF12
entrez
388581
canonical
uniprot
Q5T7M4
canonical
ensembl
ENSG00000184163
resolver
ensp
ENSP00000329137
resolver
ensp
ENSP00000755812
resolver
ensp
ENSP00000755813
resolver
enst
ENST00000330388
resolver
genesymbol
C1QTNF12
resolver
genesymbol_syn
C1QDC2
resolver
genesymbol_syn
CTRP12
resolver
genesymbol_syn
FAM132A
resolver
hgnc
HGNC:32308
resolver
uniprot
Q5EBL5
resolver
uniprot_entry
ADIPL_HUMAN
resolver
uniprot_sec
Q5EBL5
resolver
amino_acid_sequence
MRRWAWAAVVVLLGPQLVLLGGVGARREAQRTQQPGQRADPPNATASASSREGLPEAPKPSQASGPEFSDAHMTWLNFVRRPDDGALRKRCGSRDKKPRDLFGPPGPPGAEVTAETLLHEFQELLKEATERRFSGLLDPLLPQGAGLRLVGEAFHCRLQGPRRVDKRTLVELHGFQAPAAQGAFLRGSGLSLASGRFTAPVSGIFQFSASLHVDHSELQGKARLRARDVVCVLICIESLCQRHTCLEAVSGLESNSRVFTLQVQGLLQLQAGQYASVFVDNGSGAVLTIQAGSSFSGLLLGT
uniprot
proteins
function
FUNCTION: Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. {ECO:0000250|UniProtKB:Q8R2Z0}.
uniprot
proteins
mass_dalton
32416
uniprot
proteins
post_translational_modification
PTM: Processed into Adipolin fC1QTNF12 and Adipolin gC1QTNF12 by FURIN. Insulin enhances endogenous C1QTNF12 cleavage. {ECO:0000250|UniProtKB:Q8R2Z0}.
uniprot
proteins
protein_family
Adipolin/erythroferrone family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
22275362
uniprot
proteins
pubmed
24492466
uniprot
proteins
sequence_length
302
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Adipolin fC1QTNF12]: Secreted {ECO:0000269|PubMed:22275362}.; SUBCELLULAR LOCATION: [Adipolin gC1QTNF12]: Secreted {ECO:0000269|PubMed:22275362}. Note=In sera is the predominant form. {ECO:0000269|PubMed:22275362}.
uniprot
proteins