ARRDC4
entrez
91947
canonical
uniprot
Q8NCT1
canonical
ensembl
ENSG00000140450
resolver
ensp
ENSP00000268042
resolver
enst
ENST00000268042
resolver
genesymbol
ARRDC4
resolver
hgnc
HGNC:28087
resolver
uniprot
A8K2F6
resolver
uniprot
Q6NSI9
resolver
uniprot_entry
A8K2F6_HUMAN
resolver
uniprot_entry
ARRD4_HUMAN
resolver
uniprot_sec
Q6NSI9
resolver
amino_acid_sequence
MGGEAGCAAAVGAEGRVKSLGLVFEDERKGCYSSGETVAGHVLLEASEPVALRALRLEAQGRATAAWGPSTCPRASASTAALAVFSEVEYLNVRLSLREPPAGEGIILLQPGKHEFPFRFQLPSEPLVTSFTGKYGSIQYCVRAVLERPKVPDQSVKRELQVVSHVDVNTPALLTPVLKTQEKMVGCWFFTSGPVSLSAKIERKGYCNGEAIPIYAEIENCSSRLIVPKAAIFQTQTYLASGKTKTIRHMVANVRGNHIASGSTDTWNGKTLKIPPVTPSILDCCIIRVDYSLAVYIHIPGAKKLMLELPLVIGTIPYNGFGSRNSSIASQFSMDMSWLTLTLPEQPEAPPNYADVVSEEEFSRHIPPYPQPPNCEGEVCCPVFACIQEFRFQPPPLYSEVDPHPSDVEESQPVSFIL
uniprot
proteins
function
FUNCTION: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake (PubMed:19605364). Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65 (PubMed:28594402). {ECO:0000250|UniProtKB:A0A0B4J1F4, ECO:0000269|PubMed:19605364, ECO:0000269|PubMed:28594402, ECO:0000305}.
uniprot
proteins
mass_dalton
45479
uniprot
proteins
protein_family
Arrestin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
19605364
uniprot
proteins
pubmed
21982743
uniprot
proteins
pubmed
23208550
uniprot
proteins
pubmed
23236378
uniprot
proteins
pubmed
28594402
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:23208550}. Cell membrane {ECO:0000269|PubMed:23208550, ECO:0000269|PubMed:23236378}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:23236378}. Note=Also found in extracellular vesicles different from exosomes. {ECO:0000250|UniProtKB:A0A0B4J1F4}.
uniprot
proteins