CD38
entrez
952
canonical
uniprot
P28907
canonical
ensembl
ENSG00000004468
resolver
ensp
ENSP00000226279
resolver
genesymbol
CD38
resolver
hgnc
HGNC:1667
resolver
uniprot
B4E006
resolver
uniprot
O00121
resolver
uniprot
O00122
resolver
uniprot
Q96HY4
resolver
uniprot_entry
B4E006_HUMAN
resolver
uniprot_entry
CD38_HUMAN
resolver
uniprot_sec
O00121
resolver
uniprot_sec
O00122
resolver
uniprot_sec
Q96HY4
resolver
activity_regulation
ACTIVITY REGULATION: ATP inhibits the cADPR hydrolyzing activity. {ECO:0000269|PubMed:8253715}.
uniprot
proteins
amino_acid_sequence
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
uniprot
proteins
ec_number
2.4.99.20
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: Multifunctional transmembrane glycoprotein able to exert enzymatic activities and also to mobilize calcium, to transduce signals, to adhere to hyaluronan and to other ligands. Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion (PubMed:7961800, PubMed:8253715). Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+) (PubMed:16690024). Has cADPR hydrolase activity (PubMed:7961800, PubMed:8253715). Functions also as a receptor that binds the ligand CD31 on endothelial cells, promoting lymphocyte activation, proliferation, and migration across the endothelial barrier (PubMed:9551996). Involved in the regulation of crucial dendritic cell functions acquired at the mature stage, such as CCL21-driven migration, survival, and Th1-polarizing activity (PubMed:16293598). In lamina propria T lymphocytes, CD38/CD31 cognate interactions initiate a multistep signaling pathway resulting in activation of LCK anf LAT, followed by cytokine release (PubMed:11259373). {ECO:0000269|PubMed:11259373, ECO:0000269|PubMed:16293598, ECO:0000269|PubMed:16690024, ECO:0000269|PubMed:7961800, ECO:0000269|PubMed:8253715, ECO:0000269|PubMed:9551996}.
uniprot
proteins
mass_dalton
34328
uniprot
proteins
mutagenesis
MUTAGEN 119; /note="C->K: Loss of cADPR hydrolase activity."; /evidence="ECO:0000269|PubMed:7961800"; MUTAGEN 119; /note="C->R,E,A: Loss of cADPR hydrolase and ADP-ribosyl cyclase activity."; /evidence="ECO:0000269|PubMed:7961800"; MUTAGEN 160; /note="C->A: Loss of cADPR hydrolase and ADP-ribosyl cyclase activity."; /evidence="ECO:0000269|PubMed:7961800"; MUTAGEN 173; /note="C->A: Loss of cADPR hydrolase and ADP-ribosyl cyclase activity."; /evidence="ECO:0000269|PubMed:7961800"; MUTAGEN 201; /note="C->D,K,A: Loss of cADPR hydrolase and ADP-ribosyl cyclase activity."; /evidence="ECO:0000269|PubMed:7961800"; MUTAGEN 201; /note="C->E: Loss of cADPR hydrolase activity."; /evidence="ECO:0000269|PubMed:7961800
uniprot
proteins
protein_family
ADP-ribosyl cyclase family
uniprot
proteins
pubmed
11259373
uniprot
proteins
pubmed
1471258
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16154090
uniprot
proteins
pubmed
16293598
uniprot
proteins
pubmed
16690024
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2319135
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7961800
uniprot
proteins
pubmed
8253715
uniprot
proteins
pubmed
9074508
uniprot
proteins
pubmed
9551996
uniprot
proteins
pubmed
9754820
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell surface {ECO:0000269|PubMed:2319135}. Cell membrane {ECO:0000269|PubMed:16293598, ECO:0000269|PubMed:8253715}; Single-pass type II membrane protein. Note=Localizes in membrane lipid domains. {ECO:0000269|PubMed:16293598}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins