Exosc9
entrez
294975
canonical
uniprot
Q4QR75
canonical
ensembl
ENSRNOG00000014674
resolver
ensembl
ENSRNOG00055002108
resolver
ensembl
ENSRNOG00060007183
resolver
ensembl
ENSRNOG00065008664
resolver
ensp
ENSRNOP00000020662
resolver
ensp
ENSRNOP00055002512
resolver
ensp
ENSRNOP00060008895
resolver
ensp
ENSRNOP00065010202
resolver
enst
ENSRNOT00000020662
resolver
enst
ENSRNOT00055003367
resolver
enst
ENSRNOT00060011815
resolver
enst
ENSRNOT00065013753
resolver
genesymbol
Exosc9
resolver
uniprot_entry
EXOS9_RAT
resolver
amino_acid_sequence
MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLLERCLRNSKCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGEEVTLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGIMLLKDQVFRCSKIAGVKVAEITELIQKALENDQRVRKEGGKFGFAESIANQRITAFKMEKAPIDTSNIEEKAEEIIAEAEPPPEVVSKPVLWTPGTAQIGEGIENSWGDLEDSEKEEEEEGGIDETVILDDTKMDTGEVSDIGSQGAPIVLSDSEEEEMIILEPEKSPKKIRAQTSANQKAPSKSQGKRRKKKRTAN
uniprot
proteins
function
FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs (By similarity). {ECO:0000250|UniProtKB:Q06265}.
uniprot
proteins
mass_dalton
48882
uniprot
proteins
protein_family
RNase PH family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
437
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q06265}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q06265}. Nucleus {ECO:0000250|UniProtKB:Q06265}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q06265}. Note=Colocalizes with SETX in nuclear foci upon induction of transcription-related DNA damage at the S phase (By similarity). {ECO:0000250|UniProtKB:Q06265}.
uniprot
proteins