Hbp1
entrez
73389
canonical
uniprot
Q8R316
canonical
ensembl
ENSMUSG00000002996
resolver
ensp
ENSMUSP00000131158
resolver
ensp
ENSMUSP00000131983
resolver
enst
ENSMUST00000167458
resolver
enst
ENSMUST00000172314
resolver
genesymbol
Hbp1
resolver
uniprot
E9Q1A8
resolver
uniprot
E9Q469
resolver
uniprot
Q3V0I4
resolver
uniprot
Q8BUS3
resolver
uniprot
Q8C199
resolver
uniprot_entry
E9Q1A8_MOUSE
resolver
uniprot_entry
E9Q469_MOUSE
resolver
uniprot_entry
HBP1_MOUSE
resolver
uniprot_sec
Q3V0I4
resolver
uniprot_sec
Q8BUS3
resolver
uniprot_sec
Q8C199
resolver
amino_acid_sequence
MVWEVKTNQMPNAVQKLLLVMDKRAPGMSDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSAIYQLSSDVSHQEYPRSSWSQNTSDIPENTHREDEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSGPAFPHDHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPSTIWHCFLKGTRLCFHKESNKEWQDVEDFARAASCDNEEEIQMGTHKGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEIHIGDVCLPPGHPDAINFDDSGVFDTFKSYDFTPMDSSAVYVLSSMARQRRASLSCGGGPGTGQEFSGSEFSKSCGSPGSSQLSSSSLYAKAVKSHSSGTVSATSPNKCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEERRMYTLEAKALAEEQKRLNPDCWKRKRTNSGSQQH
uniprot
proteins
function
FUNCTION: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity). {ECO:0000250|UniProtKB:O60381, ECO:0000269|PubMed:9178770}.
uniprot
proteins
mass_dalton
57645
uniprot
proteins
mutagenesis
MUTAGEN 370; /note="L->D: Strongly reduces Sin3A binding."; /evidence="ECO:0000269|PubMed:15235594"; MUTAGEN 373; /note="M->D: Strongly reduces Sin3A binding."; /evidence="ECO:0000269|PubMed:15235594
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the CTLH E3 ubiquitin-protein ligase complex, leading to subsequent proteasomal degradation. {ECO:0000250|UniProtKB:O60381}.
uniprot
proteins
pubmed
14872137
uniprot
proteins
pubmed
15235594
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9178770
uniprot
proteins
sequence_length
516
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:15235594}.
uniprot
proteins