Slc39a6
entrez
106957
canonical
uniprot
Q8C145
canonical
ensembl
ENSMUSG00000024270
resolver
ensp
ENSMUSP00000064667
resolver
enst
ENSMUST00000070726
resolver
genesymbol
Slc39a6
resolver
genesymbol_syn
Zip6
resolver
uniprot
Q7TPP9
resolver
uniprot
Q7TQE0
resolver
uniprot
Q8R518
resolver
uniprot_entry
S39A6_MOUSE
resolver
uniprot_sec
Q7TPP9
resolver
uniprot_sec
Q7TQE0
resolver
uniprot_sec
Q8R518
resolver
amino_acid_sequence
MATDLSVIMILTFALWVTSPLHELQSTAAFSQTTEKINSNWEPGVNVDLAVTMQRHHLQQLFYRYGENDSLSVEGFRKLLQNIGIDKIKRVHIHHDHEHHADHEHHSDHEHHSDHEHHSDHEHHSDHEHHSDHEHHSHRSHTVAGKNNRKAFCPDLDSDNSGKNPRTSLGKGSRPAEHMNGRRNIKESASSSEVTSAVYNAVSEGTRFVETIETPKPGRRTKDVNPSTPPSITEKSRVGRLSRLARKKSNESVSEPRKSFMYSRNTNDNIQECFNTTKLLTSHGMSIQALLNATEFNYLCPAIINQIDARACLIHTASEKKAEIPPKTYSLQIAWLGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSFLVALAVGTLSGDALLHLLPHSHASHQHSHSHEEPAMEMKRGPLFSHLSAQNIEESSYFDSTWKGLTALGGLYFMFLVEHVLTLIKQFKDKKKKNQKKPENDEDVESKKQLSKYDSQLSSNEEKVDPGERPESYLRADSQEPSPFDSQQPTMLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHHILHHHHHQNHHPHSHSQRYSREELKDAGIATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSSGLSTSVAVFCHELPHELGDFAVLLKAGMTVKQAVLYNALSAMLAYLGMATGIFIGHYAENVSMWIFALTAGLFMYVALVDMVPEMLHNDASDHGCSRWGYFFLQNAGILLGFGIMLLISIFEHKIVFRINF
uniprot
proteins
function
FUNCTION: Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:28098160). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (By similarity). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (PubMed:28098160). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as E-cadherin, causing loss of cell adherence (By similarity). In addition, the SLC39A10-SLC39A6 heterodimer plays an essential role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (By similarity). Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes (By similarity). Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (PubMed:25143461). {ECO:0000250|UniProtKB:Q13433, ECO:0000250|UniProtKB:Q6L8F3, ECO:0000269|PubMed:25143461, ECO:0000269|PubMed:28098160}.
uniprot
proteins
mass_dalton
86380
uniprot
proteins
post_translational_modification
PTM: Cleaved on the N-terminus before locating to the plasma membrane. {ECO:0000250|UniProtKB:Q13433}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q13433}.; PTM: Phosphorylated by ZAP70 in response to TCR stimulation leading to its activation. {ECO:0000250|UniProtKB:Q13433}.
uniprot
proteins
protein_family
ZIP transporter (TC 2.A.5) family
uniprot
proteins
pubmed
11891044
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25143461
uniprot
proteins
pubmed
28098160
uniprot
proteins
sequence_length
765
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25143461}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13433}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:Q13433}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13433}. Membrane raft {ECO:0000250|UniProtKB:Q13433}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q4V887}. Note=Localizes to lipid rafts in T cells and is recruited into the immunological synapse in response to TCR stimulation (By similarity). In the choroid plexus is limited to the apical membrane in epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q13433, ECO:0000250|UniProtKB:Q4V887}.
uniprot
proteins
transmembrane_region
TRANSMEM 336..356; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 366..386; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 434..454; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 668..688; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 697..717; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 735..755; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins