Nat8
entrez
68396
canonical
uniprot
Q9JIY7
canonical
ensembl
ENSMUSG00000030004
resolver
ensp
ENSMUSP00000032073
resolver
ensp
ENSMUSP00000317669
resolver
ensp
ENSMUSP00000363793
resolver
enst
ENSMUST00000032073
resolver
genesymbol
Nat8
resolver
genesymbol_syn
Cml4
resolver
uniprot_entry
NAT8_MOUSE
resolver
amino_acid_sequence
MASFRIRQFQERDYKQVVDVFSRGMEEHIPTAFRHLLTLPRTLLLLAVVPLAIVLVSGSWFLAVVCIFFLFLFLWFLASKPWKNYVSKCLHTDMADITKSYLSVRGSGFWVAESGGQVVGTVAARPVKDPPLGRKQLQLFRLSVSSQHRGQGIAKALTRTVLQFARDQGYSDVVLVTGLLQQGAVTLYYSMGFQKTGESFVDILTWLVDVSLIHFIYPLPSAQKYEL
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.80
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER)-membrane-bound lysine N-acetyltransferase catalyzing the N6-acetylation of lysine residues in the lumen of the ER in various proteins, including PROM1 and BACE1, using acetyl-CoA as acetyl donor. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (By similarity). N(6)-lysine acetylation in the ER maintains protein homeostasis and regulates reticulophagy (PubMed:33846551). Alternatively, acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids. This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile (By similarity). {ECO:0000250|UniProtKB:Q9UHE5, ECO:0000269|PubMed:33846551}.
uniprot
proteins
mass_dalton
25638
uniprot
proteins
pathway_participation
PATHWAY: Sulfur metabolism; glutathione metabolism. {ECO:0000250|UniProtKB:Q9UHE5}.
uniprot
proteins
protein_family
NAT8 family
uniprot
proteins
pubmed
11397015
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22267734
uniprot
proteins
pubmed
33846551
uniprot
proteins
sequence_length
227
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q9UHE5}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9UHE5}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UHE5}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9UHE5}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000250|UniProtKB:Q9UHE5
uniprot
proteins