Eif2b1
entrez
64514
canonical
uniprot
Q64270
canonical
ensembl
ENSRNOG00000001039
resolver
ensp
ENSRNOP00000075870
resolver
enst
ENSRNOT00000092416
resolver
genesymbol
Eif2b1
resolver
genesymbol_syn
Eif2ba
resolver
uniprot
A0A0U1RRZ2
resolver
uniprot_entry
A0A0U1RRZ2_RAT
resolver
uniprot_entry
EI2BA_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by the chemical integrated stress response (ISR) inhibitor ISRIB which stimulates guanine nucleotide exchange factor activity for both phosphorylated and unphosphorylated eIF2. {ECO:0000250|UniProtKB:Q14232}.
uniprot
proteins
amino_acid_sequence
MEDGELIKYFKSQMKGDPNMASAVAAIQTLLEFLKRDKGETIQGLRAHLTKAIETLCAVDSSVAVSSGGELFLRFISLTSLEYSDYSKCKKIMIERGELFLSRISLSRTKIASLCHAFIKDGARILTHAYSRVVLRVLEEAVAAKKRFSVYITESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKVDLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKSVQAGQDLKEEHPWVDYTSPSLITLLFTDLGVLTPSAVSDELIKLYL
uniprot
proteins
function
FUNCTION: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed. {ECO:0000250|UniProtKB:Q14232}.
uniprot
proteins
mass_dalton
33678
uniprot
proteins
protein_family
EIF-2B alpha/beta/delta subunits family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7495858
uniprot
proteins
pubmed
7753796
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9USP0}.
uniprot
proteins