CRTC2
entrez
200186
canonical
uniprot
Q53ET0
canonical
ensembl
ENSG00000160741
resolver
ensp
ENSP00000357622
resolver
ensp
ENSP00000540658
resolver
ensp
ENSP00000713135
resolver
ensp
ENSP00000756140
resolver
enst
ENST00000368633
resolver
genesymbol
CRTC2
resolver
genesymbol_syn
TORC2
resolver
hgnc
HGNC:27301
resolver
uniprot
Q6UUV8
resolver
uniprot
Q7Z3X7
resolver
uniprot
Q8N332
resolver
uniprot_entry
CRTC2_HUMAN
resolver
uniprot_sec
Q6UUV8
resolver
uniprot_sec
Q7Z3X7
resolver
uniprot_sec
Q8N332
resolver
amino_acid_sequence
MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQAQKLRLAYTRSSHYGGSLPNVNQIGSGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDPRRMVSPLRRYTRHIDSSPYSPAYLSPPPESSWRRTMAWGNFPAEKGQLFRLPSALNRTSSDSALHTSVMNPSPQDTYPGPTPPSILPSRRGGILDGEMDPKVPAIEENLLDDKHLLKPWDAKKLSSSSSRPRSCEVPGINIFPSPDQPANVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETAYPSLSGGNSTSNLTHTMTHLGISRGMGLGPGYDAPGLHSPLSHPSLQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSLARHVLPTTSLGHPSLSAPALSSSSSSSSTSSPVLGAPSYPASTPGASPHHRRVPLSPLSLLAGPADARRSQQQLPKQFSPTMSPTLSSITQGVPLDTSKLSTDQRLPPYPYSSPSLVLPTQPHTPKSLQQPGLPSQSCSVQSSGGQPPGRQSHYGTPYPPGPSGHGQQSYHRPMSDFNLGNLEQFSMESPSASLVLDPPGFSEGPGFLGGEGPMGGPQDPHTFNHQNLTHCSRHGSGPNIILTGDSSPGFSKEIAAALAGVPGFEVSAAGLELGLGLEDELRMEPLGLEGLNMLSDPCALLPDPAVEESFRSDRLQ
uniprot
proteins
function
FUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}.
uniprot
proteins
mass_dalton
73302
uniprot
proteins
mutagenesis
MUTAGEN 70; /note="S->A: No effect on cAMP- and calcium-regulated phosphorylation."; MUTAGEN 171; /note="S->A: Loss of cAMP- and calcium-regulated phosphorylation. Greatly reduced interaction with 14-3-3 proteins. Impaired phosphorylation under low glucose conditions and impaired interaction with 14-3-3 proteins; when associated with A-274."; /evidence="ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:18626018"; MUTAGEN 274; /note="S->A: Impaired phosphorylation under low glucose conditions and impaired interaction with 14-3-3 proteins; when associated with A-171."; /evidence="ECO:0000269|PubMed:18626018"; MUTAGEN 368; /note="S->A: Reduced cAMP- and calcium-regulated phosphorylation."; /evidence="ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:18626018"; MUTAGEN 393; /note="S->A: No effect on cAMP- and calcium-regulated phosphorylation.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation/dephosphorylation states of Ser-171 are required for regulating transduction of CREB activity (PubMed:15589160, PubMed:17210223). CRTCs/TORCs are inactive when phosphorylated, and active when dephosphorylated at this site (PubMed:17210223). This primary site of phosphorylation, is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs (SIK1 and SIK2) by LKB1 (PubMed:15454081, PubMed:16817901). Following adenylyl cyclase activation, dephosphorylated at Ser-171 by PPP3CA/calcineurin A resulting in CRTC2 dissociation from 14-3-3 proteins and PPP3CA (By similarity). Both insulin and AMPK increase this phosphorylation of CRTC2 while glucagon suppresses it (PubMed:15454081). Phosphorylation at Ser-274 by MARK2 is induced under low glucose conditions and dephosphorylated in response to glucose influx (PubMed:18626018). Phosphorylation at Ser-274 promotes interaction with 14-3-3 proteins and translocation to the cytoplasm (PubMed:18626018). {ECO:0000250|UniProtKB:Q3U182, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15589160, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:18626018}.; PTM: Asymmetric dimethylation of arginine resisues by PRMT6 enhances the association of CRTC2 with CREB on the promoters of gluconeogenic genes. {ECO:0000250|UniProtKB:Q3U182}.
uniprot
proteins
protein_family
TORC family
uniprot
proteins
pubmed
14506290
uniprot
proteins
pubmed
14536081
uniprot
proteins
pubmed
15454081
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15589160
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16809310
uniprot
proteins
pubmed
16817901
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
16980408
uniprot
proteins
pubmed
17210223
uniprot
proteins
pubmed
17950019
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18626018
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
30611118
uniprot
proteins
sequence_length
693
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15589160}. Nucleus {ECO:0000269|PubMed:15589160}. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein (PubMed:15454081). In response to cAMP levels and glucagon, relocated to the nucleus (PubMed:15454081). {ECO:0000269|PubMed:15454081}.
uniprot
proteins