OSBPL9
entrez
114883
canonical
uniprot
Q96SU4
canonical
ensembl
ENSG00000117859
resolver
ensp
ENSP00000354970
resolver
ensp
ENSP00000360779
resolver
ensp
ENSP00000407168
resolver
ensp
ENSP00000412733
resolver
ensp
ENSP00000413263
resolver
ensp
ENSP00000431980
resolver
ensp
ENSP00000433083
resolver
ensp
ENSP00000433279
resolver
genesymbol
OSBPL9
resolver
genesymbol_syn
ORP9
resolver
genesymbol_syn
OSBP4
resolver
hgnc
HGNC:16386
resolver
uniprot
B1AKJ6
resolver
uniprot
B1AKJ8
resolver
uniprot
B3KPQ4
resolver
uniprot
B3KW33
resolver
uniprot
D3DQ31
resolver
uniprot
Q5TFC0
resolver
uniprot
Q6IA67
resolver
uniprot
Q86YQ3
resolver
uniprot
Q8NB17
resolver
uniprot
Q8TAS8
resolver
uniprot
Q96SK4
resolver
uniprot
Q9H9X2
resolver
uniprot_entry
B1AKJ6_HUMAN
resolver
uniprot_entry
B3KW33_HUMAN
resolver
uniprot_entry
OSBL9_HUMAN
resolver
uniprot_sec
B1AKJ8
resolver
uniprot_sec
B3KPQ4
resolver
uniprot_sec
D3DQ31
resolver
uniprot_sec
Q5TFC0
resolver
uniprot_sec
Q6IA67
resolver
uniprot_sec
Q86YQ3
resolver
uniprot_sec
Q8NB17
resolver
uniprot_sec
Q8TAS8
resolver
uniprot_sec
Q96SK4
resolver
uniprot_sec
Q9H9X2
resolver
amino_acid_sequence
MASIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETILRHTLQLQGLDSGFVPSVQDFDKKLTEADAYLQILIEQLKLFDDKLQNCKEDEQRKKIETLKETTNSMVESIKHCIVLLQIAKDQSNAEKHADGMISTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRPSSLPVGPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFSYSSSEDEFYDADEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKSVIMHLLSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLWKDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLKRLGAAKH
uniprot
proteins
function
FUNCTION: Interacts with OSBPL11 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). Interacts with OSBPL10 to function as lipid transfer proteins (PubMed:36853333). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:36853333). {ECO:0000269|PubMed:36853333, ECO:0000269|PubMed:39106189}.
uniprot
proteins
mass_dalton
83185
uniprot
proteins
protein_family
OSBP family
uniprot
proteins
pubmed
11735225
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20599956
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22906437
uniprot
proteins
pubmed
23033978
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
36853333
uniprot
proteins
pubmed
39106189
uniprot
proteins
sequence_length
736
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:20599956, ECO:0000269|PubMed:36853333}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:20599956, ECO:0000269|PubMed:36853333}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:36853333, ECO:0000269|PubMed:39106189}. Note=Localizes at the Golgi-late endosome interface. {ECO:0000269|PubMed:20599956, ECO:0000269|PubMed:36853333}.
uniprot
proteins