Slc14a1
entrez
108052
canonical
uniprot
Q8VHL0
canonical
ensembl
ENSMUSG00000059336
resolver
ensp
ENSMUSP00000089421
resolver
ensp
ENSMUSP00000125114
resolver
ensp
ENSMUSP00000125367
resolver
genesymbol
Slc14a1
resolver
uniprot
Q3U542
resolver
uniprot
Q497G1
resolver
uniprot
Q5RJG2
resolver
uniprot
Q6PDP4
resolver
uniprot
Q9CZX3
resolver
uniprot_entry
UT1_MOUSE
resolver
uniprot_sec
Q3U542
resolver
uniprot_sec
Q497G1
resolver
uniprot_sec
Q5RJG2
resolver
uniprot_sec
Q6PDP4
resolver
uniprot_sec
Q9CZX3
resolver
amino_acid_sequence
MEDSPTMVKVDRGENQILSCRGRRCGFKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILVGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSNKGDYFWWLIFPVSAMSMTCPVFSSALSSVLSKWDLPVFTLPFNMALSMYLSATGHYNTFFPSKLFTPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGGIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFEDIYFGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMAHLMAVVHLPACTWSFCLATLLFLLLTTKNPNIYRMPLSKVTYSEENRIFYLQNKKRMVESPL
uniprot
proteins
function
FUNCTION: Mediates the transport of urea driven by a concentration gradient across the cell membranes of erythrocytes and the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (PubMed:11792714). Facilitates water transport in erythrocytes (PubMed:12133842). {ECO:0000269|PubMed:11792714, ECO:0000269|PubMed:12133842}.
uniprot
proteins
mass_dalton
42126
uniprot
proteins
post_translational_modification
PTM: N-glycosylated in red blood cells, as well as in most non-erythroid tissues, except in the gastrocnemius muscle and in the gastrointestinal tract, including liver, colon and stomach. {ECO:0000269|PubMed:15563580}.
uniprot
proteins
protein_family
Urea transporter family
uniprot
proteins
pubmed
11792714
uniprot
proteins
pubmed
12133842
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15563580
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12133842, ECO:0000269|PubMed:15563580}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:15563580}; Multi-pass membrane protein {ECO:0000255}. Note=Restricted to the basolateral membrane in various portions of the urothelium. {ECO:0000269|PubMed:15563580}.
uniprot
proteins
transmembrane_region
TRANSMEM 61..81; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 85..105; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 111..131; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 138..158; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 250..270; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 276..296; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 327..347; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins