Tmem150b
entrez
330460
canonical
uniprot
Q8R218
canonical
ensembl
ENSMUSG00000046456
resolver
ensp
ENSMUSP00000083549
resolver
ensp
ENSMUSP00000083550
resolver
genesymbol
Tmem150b
resolver
uniprot
Q8C9L9
resolver
uniprot_entry
T150B_MOUSE
resolver
uniprot_sec
Q8C9L9
resolver
amino_acid_sequence
MWNYLSLLPVILFLWAIAGIWIVFAIAVVNGSVDLNEGFPFISICGSYAPQSCIFGQVLNIGAALTVWICIVRHHQLRDWGVKTWQNQLILWSGILCALGTSIVGNFQDKNQKPTHLAGAFLAFILGNLYFWLQFFLSWWVKGLPQPGPHWIKSLRLSLCSLSTILIVAMIVLHALHMRSASAICEWVVAMLLFMLFGFFAVDFSILRGCTLHLHPRLDSSLPQAPSGSPNIQMAQVL
uniprot
proteins
function
FUNCTION: Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (By similarity). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (By similarity). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (By similarity). {ECO:0000250|UniProtKB:A6NC51}.
uniprot
proteins
mass_dalton
26578
uniprot
proteins
protein_family
DRAM/TMEM150 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A6NC51}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A6NC51}. Endosome membrane {ECO:0000250|UniProtKB:A6NC51}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:A6NC51}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes mainly at the plasma membrane where it concentrates at actin-rich focal adhesions (By similarity). {ECO:0000250|UniProtKB:A6NC51}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 157..177; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 187..207; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins