MRAS
entrez
22808
canonical
uniprot
O14807
canonical
ensembl
ENSG00000158186
resolver
ensp
ENSP00000289104
resolver
ensp
ENSP00000389682
resolver
ensp
ENSP00000418356
resolver
ensp
ENSP00000419582
resolver
ensp
ENSP00000481637
resolver
ensp
ENSP00000484586
resolver
ensp
ENSP00000619820
resolver
ensp
ENSP00000619822
resolver
ensp
ENSP00000678319
resolver
genesymbol
MRAS
resolver
genesymbol_syn
RRAS3
resolver
hgnc
HGNC:7227
resolver
uniprot
B4DIK0
resolver
uniprot
D3DNE8
resolver
uniprot
Q6FGP0
resolver
uniprot
Q86WX8
resolver
uniprot
Q8WVM9
resolver
uniprot_entry
Q6FGP0_HUMAN
resolver
uniprot_entry
Q8WVM9_HUMAN
resolver
uniprot_entry
RASM_HUMAN
resolver
uniprot_sec
B4DIK0
resolver
uniprot_sec
D3DNE8
resolver
uniprot_sec
Q86WX8
resolver
amino_acid_sequence
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIPEKSQKKKKKTKWRGDRATGTHKLQCVIL
uniprot
proteins
disease_involvement
DISEASE: Noonan syndrome 11 (NS11) [MIM:618499]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. NS11 inheritance is autosomal dominant. {ECO:0000269|PubMed:28289718, ECO:0000269|PubMed:31173466}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:16630891, PubMed:28289718, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The formation of the SMP complex only occurs when MRAS is GTP-bound (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39809765). Unlike other Ras proteins, MRAS has low intrinsic GTPase activity and may require additional factors for activation (PubMed:39809765). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (PubMed:40934300). {ECO:0000269|PubMed:16630891, ECO:0000269|PubMed:28289718, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39809765, ECO:0000269|PubMed:40934300}.
uniprot
proteins
mass_dalton
23846
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="G->V: Promotes GTP binding."; /evidence="ECO:0000269|PubMed:39809765"; MUTAGEN 41; /note="D->A: Impairs SMP complex formation."; /evidence="ECO:0000269|PubMed:36175670"; MUTAGEN 53; /note="H->A: Impairs SMP complex formation."; /evidence="ECO:0000269|PubMed:36175670"; MUTAGEN 71; /note="Q->L: Promotes SMP complex formation. Promotes GTP binding."; /evidence="ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39809765"; MUTAGEN 74; /note="F->A,Y: Impairs SMP complex formation."; /evidence="ECO:0000269|PubMed:36175670"; MUTAGEN 131..133; /note="MHL->AA: Impairs SMP complex formation when mutated to corresponding residues in HRAS."; /evidence="ECO:0000269|PubMed:36175670"; MUTAGEN 131..133; /note="MHL->PS: Impairs SMP complex formation when mutated to corresponding residues in KRAS."; /evidence="ECO:0000269|PubMed:36175670"; MUTAGEN 132; /note="H->A: Impairs SMP complex formation."; /evidence="ECO:0000269|PubMed:36175670
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10477695
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16630891
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
28289718
uniprot
proteins
pubmed
31173466
uniprot
proteins
pubmed
35768504
uniprot
proteins
pubmed
35830882
uniprot
proteins
pubmed
35831509
uniprot
proteins
pubmed
36175670
uniprot
proteins
pubmed
39809765
uniprot
proteins
pubmed
40934300
uniprot
proteins
pubmed
9400994
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
uniprot
proteins