Tsen2
entrez
381802
canonical
uniprot
Q6P7W5
canonical
ensembl
ENSMUSG00000042389
resolver
ensp
ENSMUSP00000038211
resolver
ensp
ENSMUSP00000280662
resolver
enst
ENSMUST00000040234
resolver
genesymbol
Tsen2
resolver
genesymbol_syn
Sen2
resolver
uniprot
Q3UYG6
resolver
uniprot_entry
SEN2_MOUSE
resolver
uniprot_sec
Q3UYG6
resolver
amino_acid_sequence
MAEAVFRAPKRKRRVYESYESPLPIPFGQDQGPRKEFRIFQAEMISNNVVVRGTEDMEQLYGKGYFGKGILSRSRPNFTIANPTLAARWKGVQTDMPIITSEKYQHRVEWARDFLRRQGHDESTVQKILTDYTEPLELPCREEKEETPQHEPLSSKADSSLEGRVEKDELPVTPGGAGQSDDLPGLGTHSDCLQEGPGHATLAAASPSSHNGHVAEDPEVLPQETLVPQGGLWPEASSQAAGEKRAAHEYVLIEEELCGAQEEEAAAASDEKLLKRKKLVCRRNPYRIFEYLQLSLEEAFFLAYALGCLSIYYEKEPLTIVKLWQAFTAVQPTFRTTYMAYHYFRSKGWVPKVGLKYGTDLLLYRKGPPFYHASYSVIIELLDDNYEGSLRRPFSWKSLAALSRVSGNVSKELMLCYLIKPSTMTAEDMETPECMKRIQVQEVILSRWVSSRERSDQDEL
uniprot
proteins
ec_number
4.6.1.16
uniprot
proteins
function
FUNCTION: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
52214
uniprot
proteins
protein_family
TRNA-intron endonuclease family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
460
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=May be transiently localized in the nucleolus. {ECO:0000250}.
uniprot
proteins