Dgkb
entrez
217480
canonical
uniprot
Q6NS52
canonical
ensembl
ENSMUSG00000036095
resolver
ensp
ENSMUSP00000037900
resolver
ensp
ENSMUSP00000152378
resolver
ensp
ENSMUSP00000233982
resolver
ensp
ENSMUSP00000233983
resolver
ensp
ENSMUSP00000233984
resolver
ensp
ENSMUSP00000233985
resolver
ensp
ENSMUSP00000233986
resolver
ensp
ENSMUSP00000233988
resolver
genesymbol
Dgkb
resolver
genesymbol_syn
Kiaa0718
resolver
uniprot
Q80TT5
resolver
uniprot_entry
DGKB_MOUSE
resolver
uniprot_sec
Q80TT5
resolver
activity_regulation
ACTIVITY REGULATION: Activated by calcium. {ECO:0000250|UniProtKB:P49621}.
uniprot
proteins
amino_acid_sequence
MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPNVKSKPALLSGGLRMNKGAITPPRSSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIIGQMMHVAEYLEWDVTELNPILHEMMEEIDYDRDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKKNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQTTLHNKCASHLKPECDCGPLKDHILPPTTICPVVLTMPSAGASVPEERQSTAKKEKSSSQQPNKATDKNKMQRANSVTMDGQGLQITPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLHFFRDVPDFRVLACGGDGTVGWILDCIEKANVVKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIESSTEIMLDRWKFEVTPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKKRSHRRIEKKGSDKRPTLTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFCSLIKRTRNRSKE
uniprot
proteins
ec_number
2.7.1.107
uniprot
proteins
function
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:20657643). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (PubMed:20657643). {ECO:0000250|UniProtKB:P49621, ECO:0000269|PubMed:20657643, ECO:0000305}.
uniprot
proteins
mass_dalton
90272
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000305|PubMed:20657643}.
uniprot
proteins
protein_family
Eukaryotic diacylglycerol kinase family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20657643
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
802
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:20657643}; Peripheral membrane protein {ECO:0000305|PubMed:20657643}. Cell membrane {ECO:0000269|PubMed:20657643}; Peripheral membrane protein {ECO:0000305|PubMed:20657643}. Cytoplasm {ECO:0000305|PubMed:20657643}. Note=Translocation to the plasma membrane is induced by phorbol esters. {ECO:0000250|UniProtKB:Q9Y6T7}.
uniprot
proteins