Q9JIS7
uniprot
Q9JIS7
canonical
amino_acid_sequence
MSESEVGKDTTPEPSPANGTGPGPEWGLCPGPPTVGTDTSGASGLGTPRRRTQHNKHKTVAVASAQRSPRALFCLTLTNPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVVNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRSCTLNHTECRGRWPGPNGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQMEEDLRGYLDWITQAEELDLHDPSVDGNLASLAEEGRAGHRPQLSELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTDTPGDEDEEEGTMASCTRCLNKIMKTRICRHFRRANRGLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPLWLTQTQEYANKVLLCLFTVEMLLKLYGLGPSVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGREKSSEGNPPKENKVLVPGGENEDAKGARSEGAAPGMEEEEEEEEEEEEEEEEEEENGAGHVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKACHTLIHHHIFTSLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNLLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYSCTDEAKHTLKESKGSFLIYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDANAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSRAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFADAWNTFDALIVVGSVVDIAVTEVNNGGHLGESSEDTSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGLVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSSFAIVYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNVPLNSDGTVTFNATLFALVRTSLKIKTEGNLDQANQELRMVIKKIWKRIKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGREAPTSTSSALQAGLRSLQDLGPEIRQALTYVTEEEEEEEEAVGQEAEEEEAENNPEPYKDSIDSQPQSRWNSRISVSLPVKEKLPDSLSTGPSDDDGLAPNSRQPSVIQAGSQPHRRSSGVFMFTIPEEGSIQLKGTQGQDNQNEEQELPDWTPDLDRAGRDSFEPSPFTTSLVQQHVNGHMSTPTFAAPHACRSEPSFTIQCLQRLGSCEDLPIPGTYHRGRTSGPSRAQGSWAAPPQKGRLLYAPLLLVEESTVGEGYLGKLGGPLRTFTCLQVPGAHPNPSHRKRGSADSLVEAVLISEGLGLFAQDPRFVALAKQEIADACHLTLDEMDSAASDLLAQRTISLYSDEESILSRFDEEDLGDEMACVHAL
uniprot
proteins
function
FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines (By similarity). Activates at more negative voltages and does not undergo calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarization. {ECO:0000250|UniProtKB:O60840}.
uniprot
proteins
mass_dalton
221926
uniprot
proteins
protein_family
CACNA1F subfamily
uniprot
proteins
protein_family
Calcium channel alpha-1 subunit (TC 1.A.1.11) family
uniprot
proteins
pubmed
10873387
uniprot
proteins
pubmed
15452577
uniprot
proteins
sequence_length
1985
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 93..111; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 130..149; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 162..180; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 202..220; /note="Helical; Name=S4 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 240..259; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 348..372; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 530..549; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 565..583; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 592..610; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 621..639; /note="Helical; Name=S4 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 659..679; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 734..758; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 877..895; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 912..931; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 944..962; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 969..988; /note="Helical; Name=S4 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1008..1027; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1118..1138; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1196..1214; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1230..1249; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1257..1278; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1296..1315; /note="Helical; Name=S4 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1335..1354; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1422..1446; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000255
uniprot
proteins