ELK1
entrez
2002
canonical
uniprot
P19419
canonical
ensembl
ENSG00000126767
resolver
ensp
ENSP00000247161
resolver
ensp
ENSP00000345585
resolver
ensp
ENSP00000366182
resolver
genesymbol
ELK1
resolver
hgnc
HGNC:3321
resolver
uniprot
B2R7H4
resolver
uniprot
O75606
resolver
uniprot
O95058
resolver
uniprot
Q86SR6
resolver
uniprot
Q969X8
resolver
uniprot
Q9UJM4
resolver
uniprot_entry
ELK1_HUMAN
resolver
uniprot_entry
Q86SR6_HUMAN
resolver
uniprot_sec
B2R7H4
resolver
uniprot_sec
O75606
resolver
uniprot_sec
O95058
resolver
uniprot_sec
Q969X8
resolver
uniprot_sec
Q9UJM4
resolver
amino_acid_sequence
MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPNVAPAAIHAAPGDTVSGKPGTPKGAGMAGPGGLARSSRNEYMRSGLYSTFTIQSLQPQPPPHPRPAVVLPSAAPAGAAAPPSGSRSTSPSPLEACLEAEEAGLPLQVILTPPEAPNLKSEELNVEPGLGRALPPEVKVEGPKEELEVAGERGFVPETTKAEPEVPPQEGVPARLPAVVMDTAGQAGGHAASSPEISQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGSGSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP
uniprot
proteins
function
FUNCTION: Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:7889942). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}.
uniprot
proteins
mass_dalton
44888
uniprot
proteins
mutagenesis
MUTAGEN 230; /note="K->R: 9-fold increase in transcriptional activator activity; when associated with R-249. Reduction in sumoylation."; /evidence="ECO:0000269|PubMed:12887893, ECO:0000269|PubMed:15210726"; MUTAGEN 249; /note="K->R: 9-fold increase in transcriptional activator activity; when associated with R-230. Reduction in sumoylation."; /evidence="ECO:0000269|PubMed:12887893, ECO:0000269|PubMed:15210726"; MUTAGEN 254; /note="K->R: Reduction in sumoylation."; /evidence="ECO:0000269|PubMed:15210726"; MUTAGEN 324; /note="S->A: No effect on ternary complex formation but loss of transcriptional activity positive regulation by MAD2L2."; /evidence="ECO:0000269|PubMed:7889942"; MUTAGEN 336; /note="T->A: No effect on ternary complex formation."; /evidence="ECO:0000269|PubMed:7889942"; MUTAGEN 353; /note="T->A: No effect on ternary complex formation."; /evidence="ECO:0000269|PubMed:7889942"; MUTAGEN 363; /note="T->A: No effect on ternary complex formation."; /evidence="ECO:0000269|PubMed:7889942"; MUTAGEN 368; /note="T->A: No effect on ternary complex formation."; /evidence="ECO:0000269|PubMed:7889942"; MUTAGEN 383; /note="S->A: 17% reduction in ternary complex formation."; /evidence="ECO:0000269|PubMed:17296730, ECO:0000269|PubMed:7889942"; MUTAGEN 389; /note="S->A: 34% reduction in ternary complex formation."; /evidence="ECO:0000269|PubMed:7889942"; MUTAGEN 417; /note="T->A: No effect on ternary complex formation."; /evidence="ECO:0000269|PubMed:7889942"; MUTAGEN 422; /note="S->A: Slight reduction in ternary complex formation."; /evidence="ECO:0000269|PubMed:7889942
uniprot
proteins
post_translational_modification
PTM: Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.; PTM: On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14. Upon bFGF stimulus, phosphorylated by PAK1 (By similarity). Phosphorylated by PRP4K at Thr-417; phosphorylation activation ELK1 transcriptional activity (PubMed:10799319). {ECO:0000250|UniProtKB:A4GTP4, ECO:0000269|PubMed:10637505, ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:17296730, ECO:0000269|PubMed:7889942, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:9430721}.
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
10231026
uniprot
proteins
pubmed
10637505
uniprot
proteins
pubmed
10742173
uniprot
proteins
pubmed
10799319
uniprot
proteins
pubmed
12887893
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14992729
uniprot
proteins
pubmed
15210726
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
15920481
uniprot
proteins
pubmed
1630903
uniprot
proteins
pubmed
17296730
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2539641
uniprot
proteins
pubmed
26612202
uniprot
proteins
pubmed
28939839
uniprot
proteins
pubmed
39406892
uniprot
proteins
pubmed
7889942
uniprot
proteins
pubmed
8855261
uniprot
proteins
pubmed
9430721
uniprot
proteins
pubmed
9795224
uniprot
proteins
sequence_length
428
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins