Ctif
entrez
269037
canonical
uniprot
Q6PEE2
canonical
ensembl
ENSMUSG00000052928
resolver
ensp
ENSMUSP00000129974
resolver
ensp
ENSMUSP00000160290
resolver
ensp
ENSMUSP00000160291
resolver
ensp
ENSMUSP00000160292
resolver
ensp
ENSMUSP00000160293
resolver
ensp
ENSMUSP00000160294
resolver
enst
ENSMUST00000165559
resolver
genesymbol
Ctif
resolver
genesymbol_syn
Gm672
resolver
genesymbol_syn
Kiaa0427
resolver
uniprot
E9Q1U6
resolver
uniprot
Q6A069
resolver
uniprot_entry
CTIF_MOUSE
resolver
uniprot_entry
E9Q1U6_MOUSE
resolver
uniprot_sec
Q6A069
resolver
amino_acid_sequence
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLTDKTEGDGESQRTQSHISQWTADCREQLDGSCSFSRGRAPPQQNGNKDNSLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGISLNDIEKVLPTWQGYHPMPHEAEIAHTKKLFRRRRNDRRRQQRPPGGNKPQQHGDHQPGSAKHNRDHQKSYQGGSGPHPSGRPTHHGYSQNRRWHHGNMKHPPGDKGEAGSHRNAKETVTVENPKLEDGPGDTGHSGLEPPCSPDTLTPAASERPTPQLPGGPEAEIKHKDTVLPERLRERPKITLLQSSKDRLRRRLKEKDRDEVAVETSSPQPSKMDRLMEILNIMRNNSSDVDAKLTSFMEEAQNSTNSEEMLGEIVRTIYQKAVSDRSFAFTAAKLCDKMALFMVEGTKFRSLLLNMLQKDFTVREELQQQDVERWLGFITFLCEVFGTMRSSTGEPFRVLVCPIYTCLRELLQSQDVKEDAVLCCSMELQSTGRLLEEQLPEMMTELLASARDKMLCPSESMLTRSLLLEVIELHANSWNPLTPPITQYYNRTIQKLTA
uniprot
proteins
function
FUNCTION: Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD) (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
67831
uniprot
proteins
protein_family
CTIF family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19648179
uniprot
proteins
sequence_length
600
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
uniprot
proteins