TMEM17
entrez
200728
canonical
uniprot
Q86X19
canonical
ensembl
ENSG00000186889
resolver
ensp
ENSP00000335094
resolver
enst
ENST00000335390
resolver
genesymbol
TMEM17
resolver
hgnc
HGNC:26623
resolver
uniprot
Q53QP7
resolver
uniprot
Q53R98
resolver
uniprot_entry
TMM17_HUMAN
resolver
uniprot_sec
Q53QP7
resolver
uniprot_sec
Q53R98
resolver
amino_acid_sequence
MELPDPVRQRLGNFSRAVFSDSNRTGPESNEGPENEMVSSLALQMSLYFNTYYFPLWWVSSIMMLHMKYSILPDYYKFIVITVIILITLIEAIRLYLGYVGNLQEKVPELAGFWLLSLLLQLPLILFLLFNEGLTNLPLEKAIHIIFTLFLAFQVVAAFLTLRKMVNQLAVRFHLQDFDRLSANRGDMRRMRSCIEEI
uniprot
proteins
function
FUNCTION: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
23046
uniprot
proteins
protein_family
TMEM17 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
26982032
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes to the transition zone of primary cilia. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..65; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 78..98; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins