Tomm40
entrez
53333
canonical
uniprot
Q9QYA2
canonical
ensembl
ENSMUSG00000002984
resolver
ensp
ENSMUSP00000032555
resolver
ensp
ENSMUSP00000104090
resolver
enst
ENSMUST00000032555
resolver
enst
ENSMUST00000093552
resolver
genesymbol
Tomm40
resolver
genesymbol_syn
Mom35
resolver
genesymbol_syn
Tom40
resolver
uniprot
Q3TBZ2
resolver
uniprot
Q3TQA1
resolver
uniprot
Q8VI26
resolver
uniprot
Q8VI27
resolver
uniprot
Q9Z2N1
resolver
uniprot_entry
TOM40_MOUSE
resolver
uniprot_sec
Q3TBZ2
resolver
uniprot_sec
Q3TQA1
resolver
uniprot_sec
Q8VI26
resolver
uniprot_sec
Q8VI27
resolver
uniprot_sec
Q9Z2N1
resolver
amino_acid_sequence
MGNVLAASSPPAGPPPPPTPSLVGLPPPPPSPPGFTLPPLGGGLGTGSSTGRGSERTPGAAASGAAAASEDGSCGCLPNPGTFEECHRKCKELFPVQMEGVKLTVNKGLSNRFQVTHTVALGTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLSPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRRPGEEGTVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSASFGYQLDLPKANFLFKGSVNSNWIVGATLEKKLPPLPLTLSLCAFLNHRKNKFLCGFGLTIG
uniprot
proteins
function
FUNCTION: Channel-forming protein that forms part of the translocase of the outer mitochondrial membrane (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria (By similarity). {ECO:0000250|UniProtKB:O96008}.
uniprot
proteins
mass_dalton
37895
uniprot
proteins
protein_family
Tom40 family
uniprot
proteins
pubmed
11745481
uniprot
proteins
pubmed
11768756
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:O96008}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O96008}. Note=Associates with the mitochondria-associated ER membrane via interaction with BCAP31. {ECO:0000250|UniProtKB:O96008}.
uniprot
proteins
transmembrane_region
TRANSMEM 101..107; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 114..121; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 128..135; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 149..154; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 159..166; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 173..179; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 187..194; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 200..206; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 216..223; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 230..237; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 247..254; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 261..265; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 270..276; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 283..290; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 298..305; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 313..318; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 323..329; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 338..345; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008"; TRANSMEM 354..358; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:O96008
uniprot
proteins