MTREX
entrez
23517
canonical
uniprot
P42285
canonical
ensembl
ENSG00000039123
resolver
ensp
ENSP00000230640
resolver
enst
ENST00000230640
resolver
genesymbol
MTREX
resolver
genesymbol
SKIV2L2
resolver
genesymbol_syn
DOB1
resolver
genesymbol_syn
KIAA0052
resolver
genesymbol_syn
MTR4
resolver
genesymbol_syn
SKIV2L2
resolver
hgnc
HGNC:18734
resolver
uniprot
Q2M386
resolver
uniprot
Q3MHC9
resolver
uniprot
Q6MZZ8
resolver
uniprot
Q6P170
resolver
uniprot
Q8N5R0
resolver
uniprot
Q8TAG2
resolver
uniprot_entry
MTREX_HUMAN
resolver
uniprot_entry
Q3MHC9_HUMAN
resolver
uniprot_sec
Q2M386
resolver
uniprot_sec
Q6MZZ8
resolver
uniprot_sec
Q6P170
resolver
uniprot_sec
Q8N5R0
resolver
uniprot_sec
Q8TAG2
resolver
activity_regulation
ACTIVITY REGULATION: Activated when MTREX is incorporated into NEXT complex an the nuclear RNA exosome complex. {ECO:0000269|PubMed:29844170, ECO:0000269|PubMed:29906447}.
uniprot
proteins
amino_acid_sequence
MADAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKAGKRFDGKLQSESTNNGKNKRDVDFEGTDEPIFGKKPRIEESITEDLSLADLMPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDGIPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCEKKAQIAIDIKSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKIKRDIVFAASLYL
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension (PubMed:27871484, PubMed:29844170, PubMed:29906447). Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT) (PubMed:21855801, PubMed:27871484, PubMed:29844170). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484, PubMed:29844170). PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters (PubMed:27871484). Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (PubMed:17412707, PubMed:29107693). May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand (PubMed:29844170). Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex (PubMed:29906447). Plays a role in DNA damage response (PubMed:29902117). {ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:29107693, ECO:0000269|PubMed:29844170, ECO:0000269|PubMed:29902117, ECO:0000269|PubMed:29906447}.
uniprot
proteins
mass_dalton
117805
uniprot
proteins
mutagenesis
MUTAGEN 253; /note="E->Q: Abolishes RNA helicase activity."; /evidence="ECO:0000269|PubMed:29844170"; MUTAGEN 658; /note="R->A: Decreased interaction with NRDE2."; /evidence="ECO:0000269|PubMed:30842217"; MUTAGEN 697; /note="E->R: Decreased interaction with NRDE2."; /evidence="ECO:0000269|PubMed:30842217"; MUTAGEN 743; /note="R->E: Decreased interaction with NRDE2. Impairs the binding of both NVL and NOP53."; /evidence="ECO:0000269|PubMed:30842217, ECO:0000269|PubMed:31358741"; MUTAGEN 989..990; /note="FE->AK: Loss of interaction with NRDE2."; /evidence="ECO:0000269|PubMed:30842217
uniprot
proteins
protein_family
Helicase family
uniprot
proteins
protein_family
SKI2 subfamily
uniprot
proteins
pubmed
11719186
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16263084
uniprot
proteins
pubmed
16782053
uniprot
proteins
pubmed
17412707
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21855801
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22817747
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
26166824
uniprot
proteins
pubmed
26456651
uniprot
proteins
pubmed
27871484
uniprot
proteins
pubmed
27905398
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29107693
uniprot
proteins
pubmed
29844170
uniprot
proteins
pubmed
29902117
uniprot
proteins
pubmed
29906447
uniprot
proteins
pubmed
30047866
uniprot
proteins
pubmed
30538148
uniprot
proteins
pubmed
30842217
uniprot
proteins
pubmed
31358741
uniprot
proteins
pubmed
7584044
uniprot
proteins
sequence_length
1042
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:30842217}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Nucleus {ECO:0000269|PubMed:16782053}. Nucleus speckle {ECO:0000269|PubMed:30842217}.
uniprot
proteins