TNFRSF1B
entrez
7133
canonical
uniprot
P20333
canonical
ensembl
ENSG00000028137
resolver
ensp
ENSP00000365435
resolver
ensp
ENSP00000527359
resolver
ensp
ENSP00000527362
resolver
ensp
ENSP00000527363
resolver
genesymbol
TNFRSF1B
resolver
genesymbol_syn
TNFBR
resolver
genesymbol_syn
TNFR2
resolver
hgnc
HGNC:11917
resolver
uniprot
B1AJZ3
resolver
uniprot
Q16042
resolver
uniprot
Q6YI29
resolver
uniprot
Q9UIH1
resolver
uniprot_entry
TNR1B_HUMAN
resolver
uniprot_sec
B1AJZ3
resolver
uniprot_sec
Q16042
resolver
uniprot_sec
Q6YI29
resolver
uniprot_sec
Q9UIH1
resolver
amino_acid_sequence
MAPVAVWAALAVGLELWAAAHALPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVPHLPADKARGTQGPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGEARASTGSSDSSPGGHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFRSQLETPETLLGSTEEKPLPLGVPDAGMKPS
uniprot
proteins
function
FUNCTION: Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF. Isoform 2 blocks TNF-induced apoptosis, which suggests that it regulates TNF function by antagonizing its biological activity. {ECO:0000269|PubMed:12370298}.
uniprot
proteins
mass_dalton
48291
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; mainly on serine residues and with a very low level on threonine residues.; PTM: A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
uniprot
proteins
pubmed
10206649
uniprot
proteins
pubmed
11197692
uniprot
proteins
pubmed
11762942
uniprot
proteins
pubmed
12161545
uniprot
proteins
pubmed
12370298
uniprot
proteins
pubmed
1328224
uniprot
proteins
pubmed
14688072
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1966549
uniprot
proteins
pubmed
2153136
uniprot
proteins
pubmed
2160731
uniprot
proteins
pubmed
2166946
uniprot
proteins
pubmed
2172983
uniprot
proteins
pubmed
2173696
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25456591
uniprot
proteins
pubmed
25609706
uniprot
proteins
pubmed
8015639
uniprot
proteins
pubmed
8069916
uniprot
proteins
pubmed
8661109
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.; SUBCELLULAR LOCATION: [Tumor necrosis factor-binding protein 2]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 258..287; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins