Tarbp2
entrez
363006
canonical
uniprot
Q3SWU0
canonical
ensembl
ENSRNOG00000042355
resolver
ensp
ENSRNOP00000061329
resolver
ensp
ENSRNOP00000079010
resolver
enst
ENSRNOT00000118634
resolver
genesymbol
Tarbp2
resolver
uniprot
A0A8I5ZPX6
resolver
uniprot_entry
A0A8I5ZPX6_RAT
resolver
uniprot_entry
TRBP2_RAT
resolver
amino_acid_sequence
MSEEDQGSGSTTGCGLPSIEQMLAANPGKTPISLLQEYGTRIGKTPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSKKAAKHKAAEVALKHLKGGSMLEPALEDSSSFSLLDSSVPEDTAVIAAEAAAPVPSALLTRSPPMEMQPPVSPQQSECNPVGALQELVVQKGWRLPEYMVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKMLLRVHTVPLDARDGNEAEPDDDHFSIGVSSRLDGLRNRGPGCTWDSLRNSVGEKILSLRNCSVGSLGSLGSACCSILSELSAEQAFHVSYLDIEELSLSGLCQCLVELSTQPATVCYGSATTREAARGDAARRALQYLRIMAGSK
uniprot
proteins
function
FUNCTION: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity). Binds in vitro to the PRM1 3'-UTR (By similarity). Seems to act as a repressor of translation (By similarity). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 (By similarity). Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation (By similarity). {ECO:0000250|UniProtKB:P97473, ECO:0000250|UniProtKB:Q15633, ECO:0000255|HAMAP-Rule:MF_03034}.
uniprot
proteins
mass_dalton
38850
uniprot
proteins
protein_family
TARBP2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03034}. Cytoplasm, perinuclear region {ECO:0000255|HAMAP-Rule:MF_03034}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03034}.
uniprot
proteins