Slc16a3
entrez
80879
canonical
uniprot
P57787
canonical
ensembl
ENSMUSG00000025161
resolver
ensp
ENSMUSP00000068854
resolver
ensp
ENSMUSP00000097706
resolver
ensp
ENSMUSP00000125846
resolver
ensp
ENSMUSP00000216818
resolver
ensp
ENSMUSP00000216819
resolver
ensp
ENSMUSP00000216824
resolver
enst
ENSMUST00000070653
resolver
enst
ENSMUST00000100130
resolver
enst
ENSMUST00000168579
resolver
genesymbol
Slc16a3
resolver
genesymbol_syn
Mct4
resolver
uniprot
Q3TMA0
resolver
uniprot
Q3UDP9
resolver
uniprot
Q9ES80
resolver
uniprot
Q9ESF8
resolver
uniprot_entry
MOT4_MOUSE
resolver
uniprot_entry
Q3TMA0_MOUSE
resolver
uniprot_entry
Q3UDP9_MOUSE
resolver
uniprot_sec
Q9ES80
resolver
uniprot_sec
Q9ESF8
resolver
amino_acid_sequence
MGGAVVDEGPTGIKAPDGGWGWAVLFGCFIITGFSYAFPKAVSVFFKELMHEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQIYLTTGVITGLGLALNFQPSLIMLNRYFNKRRPIANGLAAAGSPVFLCALSPLGQLLQDHYGWRGGFLILGGLLLNCCVCAALMRPLVAPQVGGGTEPRGPQRPPQRLLDLSVFRDRGFLIYAVAASIMVLGLFVPPVFVVSYAKDMGVPDTKAAFLLTILGFIDIFARPTAGFITGLKKVRPYSVYLFSFAMFFNGFTDLTGSTATDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLLEAVAVLIGPPSGGKLLDATKVYKYVFILAGAEVLTSSLVLLLGNFFCIGKRKRPEVTEPEEVASEEKLHKPPVDVGVDSREVEHFLKAEPEKNGEVVHTPETSV
uniprot
proteins
function
FUNCTION: Proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate (By similarity). Plays a predominant role in the L-lactate efflux from highly glycolytic cells (Probable). {ECO:0000250|UniProtKB:O15427, ECO:0000305|PubMed:31837519}.
uniprot
proteins
mass_dalton
50373
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
31837519
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O15427}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:O15427}; Multi-pass membrane protein {ECO:0000255}. Note=Plasma membrane localization is dependent upon the BSG/MCT4 interaction. Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression in polarised epithelial cells. {ECO:0000250|UniProtKB:O15427}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 85..105; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 180..200; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 268..288; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 299..319; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 322..342; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 356..376; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 392..412; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins