Kcnj4
entrez
116649
canonical
uniprot
P52190
canonical
ensembl
ENSRNOG00000013869
resolver
ensp
ENSRNOP00000053014
resolver
ensp
ENSRNOP00000102507
resolver
ensp
ENSRNOP00000104988
resolver
enst
ENSRNOT00000018564
resolver
enst
ENSRNOT00000122959
resolver
enst
ENSRNOT00000156013
resolver
genesymbol
Kcnj4
resolver
genesymbol_syn
Irk3
resolver
uniprot
G3V9M7
resolver
uniprot
O35752
resolver
uniprot_entry
G3V9M7_RAT
resolver
uniprot_entry
KCNJ4_RAT
resolver
uniprot_sec
O35752
resolver
amino_acid_sequence
MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEPSPSGPTAGGPGGNGGGAAPTAAKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMPRPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEETGIIRMLEFGSHLDLERMQAATLPLDNISYRRESAI
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. {ECO:0000269|PubMed:7624316, ECO:0000269|PubMed:7796907}.
uniprot
proteins
mass_dalton
49690
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ4 subfamily
uniprot
proteins
pubmed
14960569
uniprot
proteins
pubmed
16855024
uniprot
proteins
pubmed
7624316
uniprot
proteins
pubmed
7796907
uniprot
proteins
pubmed
7874445
uniprot
proteins
sequence_length
446
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14960569}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P52189}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P52189}; Multi-pass membrane protein {ECO:0000255}. Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 family members and KCNJ4 internalization. {ECO:0000250|UniProtKB:P52189}.
uniprot
proteins
transmembrane_region
TRANSMEM 56..80; /note="Helical; Name=M1"; /evidence="ECO:0000250"; TRANSMEM 149..170; /note="Helical; Name=M2"; /evidence="ECO:0000250
uniprot
proteins