Snx27
entrez
260323
canonical
uniprot
Q8K4V4
canonical
ensembl
ENSRNOG00000020893
resolver
ensp
ENSRNOP00000028389
resolver
ensp
ENSRNOP00000107295
resolver
enst
ENSRNOT00000028389
resolver
genesymbol
Snx27
resolver
genesymbol_syn
Mrt1
resolver
uniprot
G3V8U4
resolver
uniprot
Q8K4T6
resolver
uniprot_entry
G3V8U4_RAT
resolver
uniprot_entry
SNX27_RAT
resolver
uniprot_sec
Q8K4T6
resolver
amino_acid_sequence
MADEDGEGIHPSTPHRNGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNGVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQAVPISVPTYKHVEQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELRVALPDGATVTVRVKKNSTTDQVYQAIAAKVGMDSTTVNYFALFEVINHSFVRKLAPNEFPHKLYVQNYTSAVPGTCLTIRKWLFTTEEEVLLNDNDLAVTYFFHQAVDDVKKGYIKAEEKSYQLQKLYEQRKMVMYLNMLRTCEGYNEIIFPHCACDSRRKGHVITAISITHFKLHACTEEGQLENQVIAFEWDEMQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKWRKENIFQMARSQQRDVAT
uniprot
proteins
function
FUNCTION: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. {ECO:0000269|PubMed:17828261, ECO:0000269|PubMed:18690037}.
uniprot
proteins
mass_dalton
61015
uniprot
proteins
mutagenesis
MUTAGEN 51; /note="Y->L: Abolishes interaction with KCNJ9."; /evidence="ECO:0000269|PubMed:21422294"; MUTAGEN 220; /note="K->A: Abolishes phosphatidylinositol-3-phosphate-binding and impairs subcellular location."; /evidence="ECO:0000269|PubMed:17828261
uniprot
proteins
pubmed
12740601
uniprot
proteins
pubmed
17351151
uniprot
proteins
pubmed
17828261
uniprot
proteins
pubmed
18690037
uniprot
proteins
pubmed
21422294
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
539
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products (By similarity). {ECO:0000250}.
uniprot
proteins