Mtm1
entrez
288762
canonical
uniprot
Q6AXQ4
canonical
ensembl
ENSRNOG00000002516
resolver
ensp
ENSRNOP00000058761
resolver
genesymbol
Mtm1
resolver
uniprot
Q5BK31
resolver
uniprot_entry
MTM1_RAT
resolver
uniprot_sec
Q5BK31
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by phosphatidylinositol 5-phosphate (PI5P). {ECO:0000250|UniProtKB:Q13496}.
uniprot
proteins
amino_acid_sequence
MASSSASDCDAHPVERESMRKVSQDGVRQDMSKSGPRLPGESAITDKEVIYICPFSGPVKGRLYITNYRLYLRSLETDLAPILDVPLGVISRIEKMGGVTSRGENSYGLDITCKDLRNLRFALKQEGHSRRDIFDVLTRHAFPLAYNLPLFAFVNEEKFKVDGWAIYNPVEEYRRQGLPDRHWRISFVNQRYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENRAAIMRCSQPLVGVGGKRSRDDERYLDIIRETNKQTSKLTIYDARPGVNAVANKATGGGYEGEDAYPHAELSFLDIHNIHVMRESLRRVRDIVYPHVEEAHWLSSLESTHWLEHIKLLLTGAIRVADKVASGLSSVLVHCSDGWDRTAQLTTLAMLMLDGFYRSIEGFEILVQKEWISFGHKFSSRIGHGDKNHADADRSPIFLQFIDCVWQMTKQFPTAFEFNECFLVAILDHLYSCRFGTFLLNCEAARERQRLAERTVSVWSLINSNKDEFTNPFYARESNRVIYPVTSVRHLELWVNYYIRWNPRIRQQPHPMEQRYNELLALRDDYIKKLEELQLATPTKLTDSSTPPSGSAQIAPRMQTHF
uniprot
proteins
ec_number
3.1.3.95
uniprot
proteins
function
FUNCTION: Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels. {ECO:0000250|UniProtKB:Q13496}.
uniprot
proteins
mass_dalton
69352
uniprot
proteins
protein_family
Non-receptor class myotubularin subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
602
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q13496}. Cell membrane {ECO:0000250|UniProtKB:Q13496}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q13496}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q13496}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q13496}. Late endosome {ECO:0000250|UniProtKB:Q13496}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q9Z2C5}. Note=Localizes as a dense cytoplasmic network. Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles. Predominantly located in the cytoplasm following interaction with MTMR12. Recruited to the late endosome following EGF stimulation (By similarity). In skeletal muscles, co-localizes with MTMR12 in the sarcomere (By similarity). {ECO:0000250|UniProtKB:Q13496, ECO:0000250|UniProtKB:Q9Z2C5}.
uniprot
proteins