Ggcx
entrez
56316
canonical
uniprot
Q9QYC7
canonical
ensembl
ENSMUSG00000053460
resolver
ensp
ENSMUSP00000070109
resolver
enst
ENSMUST00000065906
resolver
genesymbol
Ggcx
resolver
uniprot
B2RS80
resolver
uniprot
Q3UXN5
resolver
uniprot
Q8CCB3
resolver
uniprot_entry
B2RS80_MOUSE
resolver
uniprot_entry
VKGC_MOUSE
resolver
uniprot_sec
Q3UXN5
resolver
uniprot_sec
Q8CCB3
resolver
activity_regulation
ACTIVITY REGULATION: Interacts with lipids such as phosphatidylcholine and cholesterol; this interaction is required for optimal carboxylation activity. {ECO:0000250|UniProtKB:P38435}.
uniprot
proteins
amino_acid_sequence
MAVHRGSALVAPASDKVQKNKSAQTSGLKQGSRMEKILGFEWTDLSSWQSVVTLLNKPTDPANLAVFRFLFAFLMLLDIPQERGLSSLDRKYLDGLDVCRFPLLDALRPLPLDWMYLVYTIMFLGALGMMLGLCYRLSCVLFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYWSVDGLLNARKKNAHVPLWNYTVLRGQIFIVYFIAGVKKLDADWVGGYSMEHLSRHWLFSPFKLVLSEELTSLLVVHWCGLLLDLSAGFLLFFDASRPVGLFFVSYFHCMNSQLFSIGMFPYVMLASSPLFCSAEWPRKLVARCPKRLQELLPTKAAPRPSASCVYKRSRGKAGPKPGLRHQLGAIFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGLTGELGYLNPGVFTQSRRWKDHADMLKQYATCLSLLLPKYNVTEPQIYFDIWVSINDRFQQRLFDPRVDIVQAVWSPFQRTPWVQPLLMDLSPWRTKLQDIKSSLDNHTEVVFIADFPGLHLENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLQEGEKMQLPAGEYHKVYTVSSSPSCYMYVYVNTTEVALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFLRRQRKLQEIERRRNSPFHERFLRFVLRKLYVFRRSFLMTRISLRNLLLGRPSLEQLAQEVTYANLRPFEPVDESSASNTDSSNHPSEPDSEHVHSEF
uniprot
proteins
ec_number
4.1.1.90
uniprot
proteins
function
FUNCTION: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant epoxidation of vitamin K hydroquinone to vitamin K epoxide (By similarity). Couples epoxidation and carboxylation in the same active site (By similarity). Catalyzes gamma-carboxylation of blood coagulation factors (F2, F7, F9 and F10) and anticoagulants such as PROC, which are essential for thrombosis (By similarity). Catalyzes gamma-carboxylation of osteocalcin/BGLAP, which is essential for bone metabolism (PubMed:25264202). Catalyzes gamma-carboxylation of matrix Gla protein (MGP) and other transmembrane gamma-Gla proteins such as PRRG2, which are essential for calcium homeostasis and haemostasis (By similarity). {ECO:0000250|UniProtKB:P38435, ECO:0000269|PubMed:25264202}.
uniprot
proteins
mass_dalton
87195
uniprot
proteins
protein_family
Vitamin K-dependent gamma-carboxylase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17327402
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25264202
uniprot
proteins
sequence_length
757
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P38435}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P38435}.
uniprot
proteins
transmembrane_region
TRANSMEM 65..80; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P38435"; TRANSMEM 115..131; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P38435"; TRANSMEM 137..150; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P38435"; TRANSMEM 162..173; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P38435"; TRANSMEM 202..216; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P38435"; TRANSMEM 252..272; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P38435"; TRANSMEM 277..289; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P38435"; TRANSMEM 296..305; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P38435"; TRANSMEM 365..377; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P38435
uniprot
proteins