FKBP4
entrez
2288
canonical
uniprot
Q02790
canonical
ensembl
ENSG00000004478
resolver
ensp
ENSP00000001008
resolver
ensp
ENSP00000628610
resolver
ensp
ENSP00000628612
resolver
enst
ENST00000001008
resolver
enst
ENST00000958550
resolver
enst
ENST00000958553
resolver
genesymbol
FKBP4
resolver
genesymbol_syn
FKBP52
resolver
hgnc
HGNC:3720
resolver
uniprot
D3DUQ1
resolver
uniprot
Q9UCP1
resolver
uniprot
Q9UCV7
resolver
uniprot_entry
FKBP4_HUMAN
resolver
uniprot_sec
D3DUQ1
resolver
uniprot_sec
Q9UCP1
resolver
uniprot_sec
Q9UCV7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by FK506. {ECO:0000269|PubMed:1279700}.
uniprot
proteins
amino_acid_sequence
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA
uniprot
proteins
ec_number
5.2.1.8
uniprot
proteins
function
FUNCTION: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}.
uniprot
proteins
mass_dalton
51805
uniprot
proteins
mutagenesis
MUTAGEN 67..68; /note="FD->DV: Decreased catalytic activity toward TRPC1."; /evidence="ECO:0000269|PubMed:19945390
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by CK2 results in loss of HSP90 binding activity. {ECO:0000250}.
uniprot
proteins
pubmed
11583998
uniprot
proteins
pubmed
12499534
uniprot
proteins
pubmed
12604780
uniprot
proteins
pubmed
1279700
uniprot
proteins
pubmed
1371107
uniprot
proteins
pubmed
1376003
uniprot
proteins
pubmed
1383226
uniprot
proteins
pubmed
15159550
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19945390
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20188096
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21730050
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2378870
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
9392437
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:2378870}. Mitochondrion {ECO:0000269|PubMed:21730050}. Nucleus {ECO:0000250|UniProtKB:P30416}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QVC8}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QVC8}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (PubMed:21730050). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity). {ECO:0000250|UniProtKB:Q9QVC8, ECO:0000269|PubMed:21730050}.
uniprot
proteins