ERV
cv_term_accession
KW-0895
canonical
uniprot_keyword
KW-0895
canonical
name
ERV
uniprot
synonym
Endogenous retrovirus
uniprot
synonym
Fossil virus
uniprot
definition
Protein encoded by proviral genes of endogenous retroviruses. When a retrovirus infects a host cell, viral reverse transcriptase (RT) makes a DNA copy of the RNA viral genome. The integrated DNA form of a retrovirus is referred to as a provirus. Proviral genes are expressed by cellular mechanisms. Retroviruses that enter the germline are referred to as endogenous retroviruses (ERVs) to distinguish them from horizontally transmitted, not passed on to host progeny, "exogenous" retroviruses. Amplification of ERV copy number via retrotransposition or reinfection has given rise to numerous ERV sequences in the vertebrate genomes. As much as 8% of the human genome, and 10% of the mouse genome, consists of sequences derived from ERV insertions.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
uniprot_keywords
uniprot
keywords