Ltk
entrez
17005
canonical
uniprot
P08923
canonical
ensembl
ENSMUSG00000027297
resolver
ensp
ENSMUSP00000028759
resolver
ensp
ENSMUSP00000080774
resolver
ensp
ENSMUSP00000138201
resolver
genesymbol
Ltk
resolver
uniprot
A2AQ22
resolver
uniprot
Q0VGZ5
resolver
uniprot_entry
LTK_MOUSE
resolver
uniprot_entry
Q0VGZ5_MOUSE
resolver
uniprot_sec
A2AQ22
resolver
activity_regulation
ACTIVITY REGULATION: Activated by ligand-binding, leading to homodimerization and autophosphorylation. {ECO:0000250|UniProtKB:Q9UM73}.
uniprot
proteins
amino_acid_sequence
MGCSHRLLLWLGAAGTILCSNSEFQTPFLTPSLLPVLVLNSQEQKVTPTPSKLEPASLPNPLGTRGPWVFNTCGASGRSGPTQTQCDGAYTGSSVMVTVGAAGPLKGVQLWRVPDTGQYLISAYGAAGGKGAQNHLSRAHGIFLSAVFFLRRGEPVYILVGQQGQDACPGGSPESQLVCLGESGEHATTYGTERIPGWRRWAGGGGGGGGATSIFRLRAGEPEPLLVAAGGGGRSYRRRPDRGRTQAVPERLETRAAAPGSGGRGGAAGGGSGWTSRAHSPQAGRSPREGAEGGEGCAEAWAALRWAAAGGFGGGGGACAAGGGGGGYRGGDTSESDLLWADGEDGTSFVHPSGELYLQPLAVTEGHGEVEIRKHPNCSHCPFKDCQWQAELWTAECTCPEGTELAVDNVTCMDLPTTASPLILMGAVVAALALSLLMMCAVLILVNQKCQGLWGTRLPGPELELSKLRSSAIRTAPNPYYCQVGLSPAQPWPLPPGLTEVSPANVTLLRALGHGAFGEVYEGLVTGLPGDSSPLPVAIKTLPELCSHQDELDFLMEALIISKFSHQNIVRCVGLSFRSAPRLILLELMSGGDMKSFLRHSRPHPGQLAPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGASRVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILERIQYCTQDPDVLNSPLPVEPGPILEEEEASRLGNRSLEGLRSPKPLELSSQNLKSWGGGLLGSWLPSGLKTLKPRCLQPQNIWNPTYGSWTPRGPQGEDTGIEHCNGSSSSSIPGIQ
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor with a tyrosine-protein kinase activity. Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (By similarity). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (By similarity). The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (By similarity). {ECO:0000250|UniProtKB:P29376, ECO:0000250|UniProtKB:Q9UM73}.
uniprot
proteins
mass_dalton
94471
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. {ECO:0000250|UniProtKB:P29376}.
uniprot
proteins
protein_family
Insulin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
14695357
uniprot
proteins
pubmed
1662793
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22079349
uniprot
proteins
pubmed
2357970
uniprot
proteins
pubmed
2836739
uniprot
proteins
pubmed
8380920
uniprot
proteins
pubmed
8995435
uniprot
proteins
sequence_length
888
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2836739, ECO:0000269|PubMed:8995435}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform A]: Endoplasmic reticulum {ECO:0000305|PubMed:8380920}. Note=Retained in the endoplasmic reticulum. {ECO:0000305|PubMed:8380920}.; SUBCELLULAR LOCATION: [Isoform B]: Endoplasmic reticulum {ECO:0000305|PubMed:8380920}. Note=Retained in the endoplasmic reticulum. {ECO:0000305|PubMed:8380920}.
uniprot
proteins
transmembrane_region
TRANSMEM 422..446; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins