ERN2
entrez
10595
canonical
uniprot
Q76MJ5
canonical
ensembl
ENSG00000134398
resolver
ensp
ENSP00000256797
resolver
ensp
ENSP00000413812
resolver
enst
ENST00000256797
resolver
enst
ENST00000457008
resolver
genesymbol
ERN2
resolver
genesymbol_syn
IRE2
resolver
hgnc
HGNC:16942
resolver
uniprot
A5YM46
resolver
uniprot
A5YM65
resolver
uniprot
E7ETG2
resolver
uniprot
Q6ZNC0
resolver
uniprot_entry
A5YM46_HUMAN
resolver
uniprot_entry
A5YM65_HUMAN
resolver
uniprot_entry
E7ETG2_HUMAN
resolver
uniprot_entry
ERN2_HUMAN
resolver
uniprot_sec
Q6ZNC0
resolver
activity_regulation
ACTIVITY REGULATION: The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain (By similarity). {ECO:0000250|UniProtKB:O75460}.
uniprot
proteins
amino_acid_sequence
MASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
3.1.26.-
uniprot
proteins
function
FUNCTION: Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. {ECO:0000269|PubMed:11175748}.
uniprot
proteins
mass_dalton
102480
uniprot
proteins
mutagenesis
MUTAGEN 548; /note="K->A: Loss of autophosphorylation, of induction of apoptosis and of 28S rRNA cleavage, attenuation of repression of protein synthesis."; /evidence="ECO:0000269|PubMed:11175748
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000269|PubMed:11175748}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
11175748
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17344846
uniprot
proteins
sequence_length
926
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11175748}; Single-pass type I membrane protein {ECO:0000269|PubMed:11175748}.
uniprot
proteins
transmembrane_region
TRANSMEM 431..451; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins