Tank
entrez
21353
canonical
uniprot
P70347
canonical
ensembl
ENSMUSG00000064289
resolver
ensp
ENSMUSP00000077219
resolver
ensp
ENSMUSP00000108114
resolver
ensp
ENSMUSP00000108120
resolver
ensp
ENSMUSP00000108121
resolver
ensp
ENSMUSP00000267860
resolver
ensp
ENSMUSP00000267861
resolver
ensp
ENSMUSP00000267869
resolver
ensp
ENSMUSP00000267882
resolver
enst
ENSMUST00000112495
resolver
enst
ENSMUST00000112502
resolver
genesymbol
Tank
resolver
genesymbol_syn
Itraf
resolver
uniprot
A2AR76
resolver
uniprot
F7DB91
resolver
uniprot
Q3TNB4
resolver
uniprot
Q3UGW0
resolver
uniprot
Q61178
resolver
uniprot
Q8C2D3
resolver
uniprot_entry
A2AR76_MOUSE
resolver
uniprot_entry
F7DB91_MOUSE
resolver
uniprot_entry
Q3TNB4_MOUSE
resolver
uniprot_entry
Q3UGW0_MOUSE
resolver
uniprot_entry
Q8C2D3_MOUSE
resolver
uniprot_entry
TANK_MOUSE
resolver
uniprot_sec
Q61178
resolver
amino_acid_sequence
MSLKRHSLRRNACHLETRAGIPTILYSDATGQRGMDKNIGEQLNRAYEAFRQACMDRDSAVRELQQKQTENYEQRIREQQEQLSFQQNLIDRLKSQLLLVDSSRDNSYGYVPLLEDSDRRKNNLTLDEPHDKVKLGTLRDKQSKVRRQEVSSGKESAKGLNIPLHHERDNIEKTFWDLKEEFHRICLLAKAQKDHLSKLNIPDIATDTQCSVPIQCTDKTEKQEALFKPQAKDDINRGMSCVTAVTPRGLGRDEEDTSFESLSKFNVKFPPMDNDSIFLHSTPEAPSILAPATPETVCQDRFNMEVRDNPGNFVKTEETLFEIQGIDPITSAIQNLKTTDKTNPSNLRATCLPAGDHNVFYVNTFPLQDPPDAPFPSLDSPGKAVRGPQQPFWKPFLNQDTDLVVPSDSDSELLKPLVCEFCQELFPPSITSRGDFLRHLNTHFNGET
uniprot
proteins
function
FUNCTION: Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage. Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus. {ECO:0000250|UniProtKB:Q92844}.
uniprot
proteins
mass_dalton
50939
uniprot
proteins
pubmed
12133833
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8608943
uniprot
proteins
pubmed
8710854
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins