Srcin1
entrez
56013
canonical
uniprot
Q9QWI6
canonical
ensembl
ENSMUSG00000038453
resolver
ensp
ENSMUSP00000103216
resolver
ensp
ENSMUSP00000103219
resolver
ensp
ENSMUSP00000103222
resolver
ensp
ENSMUSP00000158676
resolver
ensp
ENSMUSP00000158711
resolver
ensp
ENSMUSP00000287684
resolver
ensp
ENSMUSP00000287685
resolver
ensp
ENSMUSP00000287686
resolver
enst
ENSMUST00000107590
resolver
enst
ENSMUST00000107593
resolver
enst
ENSMUST00000107596
resolver
genesymbol
Srcin1
resolver
genesymbol_syn
Kiaa1684
resolver
genesymbol_syn
P140
resolver
uniprot
B1AQX6
resolver
uniprot
B1AQX7
resolver
uniprot
B1AQX9
resolver
uniprot
O70298
resolver
uniprot_entry
B1AQX6_MOUSE
resolver
uniprot_entry
B1AQX7_MOUSE
resolver
uniprot_entry
B1AQX9_MOUSE
resolver
uniprot_entry
SRCN1_MOUSE
resolver
uniprot_sec
O70298
resolver
amino_acid_sequence
MQPWQCLRRFALAWWERTAEGRARSPREEVGPRDPGGRGEPDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQVGGWTVDPVCLLSSLCSHLHGDSTPSGAGQPAQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPASHLASSSPPPGLPSGLPSGLPSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPTGQGVSPSPSAILERRDVKPDEDLAGKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAETHSHTRARAACTSGVPCALSAPTPLPRCSPTWRTRCTRRALAALYGDGYGFRLPPSSPQKLADVSAPSGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKARSTGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKVEGSNGAATPSAPVCGSGSKSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRNVQLQNQESVRALLKPTEADVSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVAHNHRLMPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGMWPPPNNLLNQSPKKVAAETDFSKGLDFEIPPPSPPLNLHELSGPAEGTPLTPKSTNPTKCLDASSKRNTDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKTHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSVFIKKAESEELEVQKPQVKLRRAVSEVVRPASTPPIMASAIKDEDDEERIIAELESGGSSVPPMKVVTPGASRLKAAQGPAGSPDKGKHGKQRTEYMRIQAQQQATKPSKEVSGPNETSSPGSEKPSGSRTSIPVLTSFGARNSSISF
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
134859
uniprot
proteins
post_translational_modification
PTM: Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands. {ECO:0000250|UniProtKB:Q9C0H9}.
uniprot
proteins
protein_family
SRCIN1 family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
14657239
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19146815
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
1250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QXY2}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QXY2}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QXY2}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9QXY2}. Presynapse {ECO:0000250|UniProtKB:Q9QXY2}. Postsynapse {ECO:0000250|UniProtKB:Q9QXY2}. Postsynaptic density {ECO:0000250|UniProtKB:Q9QXY2}. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions. {ECO:0000250|UniProtKB:Q9QXY2}.
uniprot
proteins