Tp63
entrez
246334
canonical
uniprot
Q9JJP6
canonical
ensembl
ENSRNOG00000001924
resolver
ensembl
ENSRNOG00055004606
resolver
ensembl
ENSRNOG00060013209
resolver
ensembl
ENSRNOG00065003713
resolver
ensp
ENSRNOP00000002636
resolver
ensp
ENSRNOP00000032308
resolver
ensp
ENSRNOP00000059178
resolver
ensp
ENSRNOP00000061884
resolver
genesymbol
Tp63
resolver
genesymbol_syn
Ket
resolver
genesymbol_syn
P63
resolver
genesymbol_syn
Tp73l
resolver
genesymbol_syn
Trp63
resolver
uniprot
Q99JD6
resolver
uniprot
Q99JD7
resolver
uniprot
Q99JD8
resolver
uniprot
Q99JD9
resolver
uniprot
Q99JE0
resolver
uniprot
Q99JE1
resolver
uniprot
Q99JE2
resolver
uniprot
Q99JE3
resolver
uniprot_entry
P63_RAT
resolver
uniprot_sec
Q99JD6
resolver
uniprot_sec
Q99JD7
resolver
uniprot_sec
Q99JD8
resolver
uniprot_sec
Q99JD9
resolver
uniprot_sec
Q99JE0
resolver
uniprot_sec
Q99JE1
resolver
uniprot_sec
Q99JE2
resolver
uniprot_sec
Q99JE3
resolver
amino_acid_sequence
MNFETSRCATLQYCPDPYIQRFIETPSHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNGMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE
uniprot
proteins
function
FUNCTION: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates RIPK4 transcription (By similarity). Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter (By similarity). Binds to an upstream regulatory region of the DSG1 gene and promotes transcription (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9H3D4, ECO:0000269|PubMed:11470269}.
uniprot
proteins
mass_dalton
76760
uniprot
proteins
post_translational_modification
PTM: May be sumoylated. {ECO:0000250}.; PTM: Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
P53 family
uniprot
proteins
pubmed
11470269
uniprot
proteins
pubmed
9315105
uniprot
proteins
sequence_length
680
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins