AFDN
entrez
4301
canonical
uniprot
P55196
canonical
ensembl
ENSG00000130396
resolver
ensp
ENSP00000252692
resolver
ensp
ENSP00000355771
resolver
ensp
ENSP00000375956
resolver
ensp
ENSP00000375960
resolver
ensp
ENSP00000404595
resolver
ensp
ENSP00000422166
resolver
ensp
ENSP00000507324
resolver
ensp
ENSP00000583620
resolver
ensp
ENSP00000583621
resolver
ensp
ENSP00000583622
resolver
ensp
ENSP00000583623
resolver
enst
ENST00000351017
resolver
enst
ENST00000366806
resolver
enst
ENST00000683244
resolver
genesymbol
AFDN
resolver
genesymbol
MLLT4
resolver
genesymbol_syn
AF6
resolver
genesymbol_syn
MLLT4
resolver
hgnc
HGNC:7137
resolver
uniprot
A0A1P7ZIN0
resolver
uniprot
A0A804HJ20
resolver
uniprot
A8MQ02
resolver
uniprot
G1UI22
resolver
uniprot
J3KN01
resolver
uniprot
O75087
resolver
uniprot
O75088
resolver
uniprot
O75089
resolver
uniprot
Q59FP0
resolver
uniprot
Q5TIG6
resolver
uniprot
Q5TIG7
resolver
uniprot
Q9NSN7
resolver
uniprot
Q9NU92
resolver
uniprot_entry
A0A1P7ZIN0_HUMAN
resolver
uniprot_entry
A0A804HJ20_HUMAN
resolver
uniprot_entry
A8MQ02_HUMAN
resolver
uniprot_entry
AFAD_HUMAN
resolver
uniprot_entry
G1UI22_HUMAN
resolver
uniprot_entry
J3KN01_HUMAN
resolver
uniprot_sec
O75087
resolver
uniprot_sec
O75088
resolver
uniprot_sec
O75089
resolver
uniprot_sec
Q59FP0
resolver
uniprot_sec
Q5TIG6
resolver
uniprot_sec
Q5TIG7
resolver
uniprot_sec
Q9NSN7
resolver
uniprot_sec
Q9NU92
resolver
amino_acid_sequence
MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAEALEKYGLEKENPKDYCIARVMLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPPDHIPKKTKKHLEGKTPKGKERADGSGYGSTLPPEKLPYLVELSPGRRNHFAYYNYHTYEDGSDSRDKPKLYRLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEGVIQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMRKREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPGLCRPPLPRDYEPPSPSPAPGAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYNEEEEEEDCSLAGPNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDVSNKVKASRKLTELENELNTK
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving AFDN is associated with acute leukemias. Translocation t(6;11)(q27;q23) with KMT2A/MLL1. The result is a rogue activator protein.
uniprot
proteins
function
FUNCTION: Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}.
uniprot
proteins
mass_dalton
206804
uniprot
proteins
pubmed
11024295
uniprot
proteins
pubmed
12456712
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15684424
uniprot
proteins
pubmed
16671149
uniprot
proteins
pubmed
17693683
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30463011
uniprot
proteins
pubmed
8242616
uniprot
proteins
pubmed
9679199
uniprot
proteins
sequence_length
1824
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Note=Not found at cell-matrix AJs. {ECO:0000250|UniProtKB:O35889}.
uniprot
proteins