Rpl11
entrez
67025
canonical
uniprot
Q9CXW4
canonical
ensembl
ENSMUSG00000059291
resolver
ensp
ENSMUSP00000099595
resolver
ensp
ENSMUSP00000121108
resolver
enst
ENSMUST00000102536
resolver
genesymbol
Rpl11
resolver
uniprot
Q3TPE3
resolver
uniprot
Q6ZWY0
resolver
uniprot_entry
RL11_MOUSE
resolver
uniprot_sec
Q3TPE3
resolver
uniprot_sec
Q6ZWY0
resolver
amino_acid_sequence
MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK
uniprot
proteins
function
FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:36517592). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:36517592). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:36517592). As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:36517592). It also couples ribosome biogenesis to p53/TP53 activation (PubMed:21804542). As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:21804542). Promotes nucleolar location of PML (PubMed:15195100). {ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:21804542, ECO:0000269|PubMed:36517592}.
uniprot
proteins
mass_dalton
20252
uniprot
proteins
protein_family
Universal ribosomal protein uL5 family
uniprot
proteins
pubmed
15195100
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21804542
uniprot
proteins
pubmed
36517592
uniprot
proteins
sequence_length
178
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:21804542}. Cytoplasm {ECO:0000269|PubMed:21804542, ECO:0000269|PubMed:36517592}.
uniprot
proteins