Npat
entrez
244879
canonical
uniprot
Q8BMA5
canonical
ensembl
ENSMUSG00000033054
resolver
ensp
ENSMUSP00000048709
resolver
enst
ENSMUST00000035850
resolver
genesymbol
Npat
resolver
uniprot
Q8BWA9
resolver
uniprot
Q8BY06
resolver
uniprot_entry
NPAT_MOUSE
resolver
uniprot_sec
Q8BWA9
resolver
uniprot_sec
Q8BY06
resolver
amino_acid_sequence
MLLPSDVARLVLGYLQQENLTSTCQTFILESSNLKEYAEHCTDEGFIPACLLSLFGKNLTTILNEYVAMKAKETSNDVPTIMSSLWKKLDHTLSQIRSMHSSPGFAAHQRARTRNGIAEIKRQRWLASQAAPVSSELLVLPYASGQFTTSPLVATQAVKPTGPISTPVRSNIVVVNQSQPQSTVTNTAGESLNIIPGPQERKTQTSLMSPGRRKSESQKKSLTSSGPHSSRNFQDPNAFAVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDSSVAQVPKQTDSNPTEPETSIDELLGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNMPQISSQPMETNSNIVLPEETNLTIKSSFETEESDGQSGQPPFCTSYQNEDVLLNDLKSGNSHDVLPQESQENFSQISSNIQKKTFKTAIPAEQKCALDITLESVSNLSDFNQRGSSAECNEHCSELFASQIPTEAEVAVGEKNSLSADILSQSQYQPDQPSVPVTSFVSLGGETNDKNLVLSGKNSQLLSQSTPLTTKPSKSQLCENSNNIIKVKTNPQASESADSSETANRKTETNTVSPAAAQPQADCQDNSPLQSKPPPGIGESLGVNVTEKIEIHLEEPAPSDKQLSNDAASVDLNPTESKTEPLQSASAQEPEPPSVKDGDTIFLSLSEHNSCEEVALVLGEGNPVKNNNSLSSESGGSVGVSPETQNTDGKTSNSTEVDASSIVSLKIIISDDPFVSSDAELNSAVSSISGENLPTIILSSKSPAKNAEFVTCLSSEETASAVVSVEVGDSGSMEQNLLVLKPEEPMVNNTQNEDGIAFSANVAPCVPKDGGYIQLMPTTSTAFGNSSNILIATCMTDSTALGPTVSQSNVVVLPGSSAPMTAQPPQQQLQTPPKSNSAFAVSQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNTFSTPPQQVLHMPLAAPVCNRSIAQLPIPQKSQKAQGLRNKLITGKQVNNLTNLSSLSEACHTQRTEASDKNIATELGKKMEDTTISLSGERVAPPSKPFESHRRVLCFDSTVSSVANTQGSLYKMTSENKEKKEASFSHLDSPILSSTLKPPPNNAIKREREKTVPKILSKSETASSRHTTVKEVQSEKKVSPTEVALESLHKATANKENELCGDGERPKNADTSKLPGGQQNGSLRNEKAIASLQELTKKQATPSNNKNATSVGGTVKDQKQEQSKPASSLIGAEILQDVPIHSPANRSADTDLPVPRTPGSGAGEKHKEEPSDSMKAPASRRCGEEGSMPRVMIPPVTADLPACSPASETGSENSVSMAAHTLMILSRAAIARTTATPLKDNTQQFRTSSRSTTKKRKIEELDECERNSRTSGKNLANSSVPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE
uniprot
proteins
function
FUNCTION: Transcription regulator required for progression through the G1 and S phases of the cell cycle and for S phase entry (By similarity). Acts as a key transcription regulator of histones (By similarity). Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with GON4L and MIZF (By similarity). Together with CRAMP1, binds to the promoters of H1 genes (H1-2, H1-3, H1-4, H1-5 and H1-10/H1x), driving their transcription (By similarity). Also positively regulates the ATM, MIZF and PRKDC promoters (By similarity). Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters (By similarity). {ECO:0000250|UniProtKB:Q14207}.
uniprot
proteins
mass_dalton
152176
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-771, Ser-773, Ser-1096, Thr-1264 and Thr-1343 by CCNE1/CDK2 at G1-S transition and until prophase, which promotes association with histone gene clusters and stimulates activation of histone transcription. Also phosphorylated by CCNA1/CDK2 in vitro (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
NPAT family
uniprot
proteins
pubmed
12665581
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17003125
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9199343
uniprot
proteins
sequence_length
1420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17003125}. Nucleus, Cajal body {ECO:0000250|UniProtKB:Q14207}. Chromosome {ECO:0000250|UniProtKB:Q14207}. Note=Localizes to histone locus bodies (HLB). Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 specifically during S and G2 phases. {ECO:0000250|UniProtKB:Q14207}.
uniprot
proteins