Card11
entrez
108723
canonical
uniprot
Q8CIS0
canonical
ensembl
ENSMUSG00000036526
resolver
ensp
ENSMUSP00000082941
resolver
genesymbol
Card11
resolver
genesymbol_syn
Carma1
resolver
uniprot
Q4VA14
resolver
uniprot
Q6KAS3
resolver
uniprot
Q8BYV0
resolver
uniprot_entry
CAR11_MOUSE
resolver
uniprot_sec
Q4VA14
resolver
uniprot_sec
Q6KAS3
resolver
uniprot_sec
Q8BYV0
resolver
activity_regulation
ACTIVITY REGULATION: Maintained in an autoinhibited state via homodimerization in which the CARD domain forms an extensive interaction with the adjacent linker and coiled-coil regions (By similarity). Activation downstream of T-cell receptor (TCR) by phosphorylation by PRKCB and PRKCQ triggers CARD11 homooligomerization and BCL10 recruitment, followed by activation of NF-kappa-B (PubMed:16356855). {ECO:0000250|UniProtKB:Q9BXL7, ECO:0000269|PubMed:16356855}.
uniprot
proteins
amino_acid_sequence
MPGGGPAMDDYMETLKDEEEALWDNVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIKLQQQVKAKDLQRCELLAKSRQLEDEKKQLSLIRVELLTFQERYYKMKEERDSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDIENRPRKEQVLELERENEMLKTKIQELQSIIQAGKRSLPDSDKAILDILEHDRKEALEDRQELVNKIYNLQEEVRQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRLSKDNGSLDQSLPRHLPATIISQNLGDTSPRTNGQEADDSSTSEESPEDSKYFLPYHPPRRRMNLKGIQLQRAKSPISMKQASEFQALMRTVKGHEEDFTDGSPSSSRSLPVTSSFSKMQPHRSRSSIMSITAEPPGNDSIVRRCKEDAPHRSTVEEDNDSCGFDALDLDDENHERYSFGPPSIHSSSSSHQSEGLDAYDLEQVNLMLRKFSLERPFRPSVTSGGHVRGTGPLVQHTTLNGDGLITQLTLLGGNARGSFIHSVKPGSLAERAGLREGHQLLLLEGCIRGERQSVPLDACTKEEARWTIQRCSGLITLHYKVNHEGYRKLLKEMEDGLITSGDSFYIRLNLNISSQLDACSMSLKCDDVVHVLDTMYQDRHEWLCARVDPFTDQDLDTGTIPSYSRAQQLLLVKLQRLVHRGNREEADSAHHTLRSLRNTLQPEEMLSTSDPRVSPRLSRASFFFGQLLQFVSRSENKYKRMNSNERVRIISGSPLGSLSRSSLDATKLLTEKHEELDPENELSRNLTLIPYSLVRAFHCERRRPVLFTPTMLAKTLVQKLLNSGGAMEFTICKSDIVTRDEFLRKQKTETIIYSREKNPNTFECIVPANIEAVAAKNKHCLLEAGIGCVRDLIKCKVYPIVLLIRVSEKNIKRFRKLLPRPETEEEFLRVCRLKEKELEALPCLYATVEAEMWSSVEELLRVLKDKIVEEQRKTIWVDEDQL
uniprot
proteins
function
FUNCTION: Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:12154356, PubMed:12356734, PubMed:16356855). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:12154356, PubMed:12356734, PubMed:16356855). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (By similarity). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (By similarity). Stimulates the phosphorylation of BCL10 (By similarity). Also activates the TORC1 signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q9BXL7, ECO:0000269|PubMed:12154356, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:16356855}.
uniprot
proteins
mass_dalton
134040
uniprot
proteins
mutagenesis
MUTAGEN 35; /note="R->A: Strongly decreased interaction with BCL10."; /evidence="ECO:0000269|PubMed:22880103"; MUTAGEN 41; /note="K->A: Slightly decreased interaction with BCL10."; /evidence="ECO:0000269|PubMed:22880103"; MUTAGEN 69; /note="K->A: Decreased interaction with BCL10."; /evidence="ECO:0000269|PubMed:22880103"; MUTAGEN 72; /note="R->A: Decreased interaction with BCL10."; /evidence="ECO:0000269|PubMed:22880103
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-564, Ser-649 and Ser-657 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling. {ECO:0000269|PubMed:16356855}.
uniprot
proteins
pubmed
12154356
uniprot
proteins
pubmed
12356734
uniprot
proteins
pubmed
15449545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16356855
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22880103
uniprot
proteins
sequence_length
1159
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BXL7}. Membrane raft {ECO:0000250|UniProtKB:Q9BXL7}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000250|UniProtKB:Q9BXL7}.
uniprot
proteins