APPBP2
entrez
10513
canonical
uniprot
Q92624
canonical
ensembl
ENSG00000062725
resolver
ensp
ENSP00000083182
resolver
enst
ENST00000083182
resolver
genesymbol
APPBP2
resolver
genesymbol_syn
KIAA0228
resolver
genesymbol_syn
PAT1
resolver
hgnc
HGNC:622
resolver
uniprot
A8K862
resolver
uniprot
O95095
resolver
uniprot
Q8WVC9
resolver
uniprot_entry
APBP2_HUMAN
resolver
uniprot_sec
A8K862
resolver
uniprot_sec
O95095
resolver
uniprot_sec
Q8WVC9
resolver
activity_regulation
ACTIVITY REGULATION: E3 ubiquitin-protein ligase activity of the CRL2(APPBP2) complex is inhibited by APP. {ECO:0000269|PubMed:29775578}.
uniprot
proteins
amino_acid_sequence
MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQNVEGPSC
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29775578, PubMed:29779948, PubMed:37844242). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29775578, PubMed:29779948, PubMed:37844242). The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation (PubMed:29775578, PubMed:29779948, PubMed:37844242). The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron (PubMed:26138980, PubMed:37844242). The CRL2(APPBP2) complex negatively regulates beige adipocyte differentiation by mediating ubiquitination and degradation of PRDM16 (By similarity). May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface (PubMed:9843960). {ECO:0000250|UniProtKB:Q9DAX9, ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:37844242, ECO:0000269|PubMed:9843960}.
uniprot
proteins
mass_dalton
66853
uniprot
proteins
mutagenesis
MUTAGEN 345; /note="Y->A: Abolished ability to recognize and bind C-degrons; when associated with A-437."; /evidence="ECO:0000269|PubMed:37844242"; MUTAGEN 380; /note="R->E: Decreased ability to recognize and bind C-degrons; when associated with E-430."; /evidence="ECO:0000269|PubMed:37844242"; MUTAGEN 387..388; /note="EE->RR: Abolished ability to recognize and bind C-degrons."; /evidence="ECO:0000269|PubMed:37844242"; MUTAGEN 430; /note="K->E: Decreased ability to recognize and bind C-degrons; when associated with E-380."; /evidence="ECO:0000269|PubMed:37844242"; MUTAGEN 437; /note="R->A: Abolished ability to recognize and bind C-degrons; when associated with A-345."; /evidence="ECO:0000269|PubMed:37844242"; MUTAGEN 476..479; /note="HLAS->ELAE: Reduced ability to recognize and bind C-degrons."; /evidence="ECO:0000269|PubMed:37844242
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:37844242}.
uniprot
proteins
post_translational_modification
PTM: Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP. {ECO:0000269|PubMed:11742091}.
uniprot
proteins
pubmed
11742091
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26138980
uniprot
proteins
pubmed
29775578
uniprot
proteins
pubmed
29779948
uniprot
proteins
pubmed
37844242
uniprot
proteins
pubmed
9039502
uniprot
proteins
pubmed
9843960
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11742091}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9843960}. Membrane {ECO:0000269|PubMed:9843960}; Peripheral membrane protein {ECO:0000269|PubMed:9843960}. Note=Associated with membranes and microtubules. {ECO:0000269|PubMed:9843960}.
uniprot
proteins