Slc25a39
entrez
68066
canonical
uniprot
Q9D8K8
canonical
ensembl
ENSMUSG00000018677
resolver
ensp
ENSMUSP00000018821
resolver
ensp
ENSMUSP00000228404
resolver
ensp
ENSMUSP00000228416
resolver
ensp
ENSMUSP00000336487
resolver
ensp
ENSMUSP00000336492
resolver
enst
ENSMUST00000018821
resolver
genesymbol
Slc25a39
resolver
genesymbol_syn
D11Ertd333e
resolver
uniprot
Q14BQ5
resolver
uniprot
Q3TTM8
resolver
uniprot_entry
Q14BQ5_MOUSE
resolver
uniprot_entry
S2539_MOUSE
resolver
uniprot_sec
Q3TTM8
resolver
activity_regulation
ACTIVITY REGULATION: The activity of SLC25A39 is regulated by levels of mitochondrial glutathione via its ability to bind [2Fe-2S] iron-sulfur cluster. Upon physiological levels of mitochondrial glutathione, glutathione prevents iron-sulfur-binding to SLC25A39 promoting cleavage and degradation by AFG3L2. Upon depletion of mitochondrial glutathione, SLC25A39 binds iron-sulfur, preventing cleavage and degradation by AFG3L2. {ECO:0000250|UniProtKB:Q9BZJ4}.
uniprot
proteins
amino_acid_sequence
MDDQDPGGISPLQQMVASGAGAVVTSLFMTPLDVVKVRLQSQRPSATSELTTPSRFWSLSYTKSSSALQSPGKCLLYCNGVLEPLYLCPNGTRCATWFQDPTRFTGTLDAFVKIVRHEGTRTLWSGLPATLVMTVPATAIYFTAYDQLKAFLCGQSLTSDLYAPMVAGALARMGTVTVVSPLELVRTKLQAQHVSYRELASSVQAAVTQGGWRSLWLGWGPTALRDVPFSALYWFNYELVKSWLSGLRPKDQTSVGISFVAGGISGMVAATLTLPFDVVKTQRQMSLGAVEAVRVKPPRVDSTWLLLRRIRAESGTRGLFAGFLPRIIKAAPSCAIMISTYEFGKSFFQRLNQEQPLGR
uniprot
proteins
function
FUNCTION: Mitochondrial transporter required for glutathione import into mitochondria (PubMed:34707288). Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (By similarity). Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis (PubMed:34707288). {ECO:0000250|UniProtKB:Q9BZJ4, ECO:0000269|PubMed:34707288}.
uniprot
proteins
mass_dalton
39221
uniprot
proteins
post_translational_modification
PTM: Cleaved and degraded by AFG3L2; degradation by AFG3L2 is regulated by the ability of SLC25A39 to bind iron-sulfur. In absence of mitochondrial glutathione, SLC25A39 binds iron-sulfur, preventing cleavage and degradation by AFG3L2. The presence of mitochondrial glutathione prevents iron-sulfur-binding to SLC25A39, promoting cleavage and degradation by AFG3L2. {ECO:0000250|UniProtKB:Q9BZJ4}.
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19656490
uniprot
proteins
pubmed
34707288
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9BZJ4}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..35; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 122..142; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 215..235; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 256..276; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 318..338; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins