NGF
entrez
4803
canonical
uniprot
P01138
canonical
ensembl
ENSG00000134259
resolver
ensp
ENSP00000358525
resolver
ensp
ENSP00000502380
resolver
ensp
ENSP00000502831
resolver
ensp
ENSP00000505558
resolver
ensp
ENSP00000505694
resolver
ensp
ENSP00000506492
resolver
ensp
ENSP00000506569
resolver
ensp
ENSP00000541260
resolver
ensp
ENSP00000541261
resolver
ensp
ENSP00000541262
resolver
ensp
ENSP00000541263
resolver
ensp
ENSP00000541264
resolver
ensp
ENSP00000599115
resolver
ensp
ENSP00000640309
resolver
ensp
ENSP00000640310
resolver
enst
ENST00000369512
resolver
enst
ENST00000675637
resolver
enst
ENST00000676038
resolver
enst
ENST00000679806
resolver
enst
ENST00000680116
resolver
enst
ENST00000680540
resolver
enst
ENST00000680752
resolver
enst
ENST00000871201
resolver
enst
ENST00000871202
resolver
enst
ENST00000871203
resolver
enst
ENST00000871204
resolver
enst
ENST00000871205
resolver
enst
ENST00000929056
resolver
enst
ENST00000970250
resolver
enst
ENST00000970251
resolver
genesymbol
NGF
resolver
genesymbol_syn
NGFB
resolver
hgnc
HGNC:7808
resolver
uniprot
A0A346FYQ1
resolver
uniprot
A1A4E5
resolver
uniprot
Q6FHA0
resolver
uniprot
Q96P60
resolver
uniprot
Q9P2Q8
resolver
uniprot
Q9UKL8
resolver
uniprot_entry
A0A346FYQ1_HUMAN
resolver
uniprot_entry
NGF_HUMAN
resolver
uniprot_sec
A1A4E5
resolver
uniprot_sec
Q6FHA0
resolver
uniprot_sec
Q96P60
resolver
uniprot_sec
Q9P2Q8
resolver
uniprot_sec
Q9UKL8
resolver
amino_acid_sequence
MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIAARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSKRSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRRA
uniprot
proteins
disease_involvement
DISEASE: Neuropathy, hereditary sensory and autonomic, 5 (HSAN5) [MIM:608654]: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable. {ECO:0000269|PubMed:14976160, ECO:0000269|PubMed:20978020, ECO:0000269|PubMed:22302274}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:14976160, PubMed:20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable) (PubMed:20978020). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity). {ECO:0000250|UniProtKB:P01139, ECO:0000269|PubMed:14976160, ECO:0000269|PubMed:20164177, ECO:0000269|PubMed:20978020, ECO:0000305|PubMed:10490030, ECO:0000305|PubMed:15131306}.
uniprot
proteins
mass_dalton
26959
uniprot
proteins
protein_family
NGF-beta family
uniprot
proteins
pubmed
10322959
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
10490030
uniprot
proteins
pubmed
14976160
uniprot
proteins
pubmed
15014171
uniprot
proteins
pubmed
15131306
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15710408
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17196528
uniprot
proteins
pubmed
1849459
uniprot
proteins
pubmed
20164177
uniprot
proteins
pubmed
2025430
uniprot
proteins
pubmed
20978020
uniprot
proteins
pubmed
22302274
uniprot
proteins
pubmed
2374737
uniprot
proteins
pubmed
6327169
uniprot
proteins
pubmed
6688123
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20978020}. Endosome lumen {ECO:0000250|UniProtKB:P01139}. Note=ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR. {ECO:0000250|UniProtKB:P01139}.
uniprot
proteins