Elovl2
entrez
54326
canonical
uniprot
Q9JLJ4
canonical
ensembl
ENSMUSG00000021364
resolver
ensp
ENSMUSP00000021793
resolver
ensp
ENSMUSP00000114112
resolver
enst
ENSMUST00000021793
resolver
enst
ENSMUST00000117096
resolver
genesymbol
Elovl2
resolver
genesymbol_syn
ELOVL2
resolver
genesymbol_syn
Ssc2
resolver
uniprot
A0A0R4J1P7
resolver
uniprot
Q543J1
resolver
uniprot
Q9D5Z2
resolver
uniprot_entry
A0A0R4J1P7_MOUSE
resolver
uniprot_entry
ELOV2_MOUSE
resolver
uniprot_entry
Q543J1_MOUSE
resolver
uniprot_sec
Q9D5Z2
resolver
amino_acid_sequence
MEQLKAFDNEVNAFLDNMFGPRDSRVRGWFLLDSYLPTFILTITYLLSIWLGNKYMKNRPALSLRGILTLYNLAITLLSAYMLVELILSSWEGGYNLQCQNLDSAGEGDVRVAKVLWWYYFSKLVEFLDTIFFVLRKKTNQITFLHVYHHASMFNIWWCVLNWIPCGQSFFGPTLNSFIHILMYSYYGLSVFPSMHKYLWWKKYLTQAQLVQFVLTITHTLSAVVKPCGFPFGCLIFQSSYMMTLVILFLNFYIQTYRKKPVKKELQEKEVKNGFPKAHLIVANGMTDKKAQ
uniprot
proteins
ec_number
2.3.1.199
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Essential for the formation of C24:5(n-6) up to C30:5(n-6) PUFAs in testis, these fatty acids being indispensable for normal spermatogenesis and fertility. {ECO:0000255|HAMAP-Rule:MF_03202, ECO:0000269|PubMed:12371743, ECO:0000269|PubMed:21106902}.
uniprot
proteins
mass_dalton
34207
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03202, ECO:0000269|PubMed:12371743, ECO:0000269|PubMed:21106902}.
uniprot
proteins
protein_family
ELO family
uniprot
proteins
protein_family
ELOVL2 subfamily
uniprot
proteins
pubmed
10791983
uniprot
proteins
pubmed
12371743
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21106902
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03202}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03202}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..49; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 67..87; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 153..173; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 175..195; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 205..225; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 230..250; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202
uniprot
proteins