ELK4
entrez
2005
canonical
uniprot
P28324
canonical
ensembl
ENSG00000158711
resolver
ensp
ENSP00000289703
resolver
ensp
ENSP00000350681
resolver
genesymbol
ELK4
resolver
genesymbol_syn
SAP1
resolver
hgnc
HGNC:3326
resolver
uniprot
P28323
resolver
uniprot
Q6GSJ2
resolver
uniprot
Q8IXL1
resolver
uniprot_entry
ELK4_HUMAN
resolver
uniprot_entry
Q8IXL1_HUMAN
resolver
uniprot_sec
P28323
resolver
uniprot_sec
Q6GSJ2
resolver
amino_acid_sequence
MDSAITLWQFLLQLLQKPQNKHMICWTSNDGQFKLLQAEEVARLWGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKFVSYPEILNMDPMTVGRIEGDCESLNFSEVSSSSKDVENGGKDKPPQPGAKTSSRNDYIHSGLYSSFTLNSLNSSNVKLFKLIKTENPAEKLAEKKSPQEPTPSVIKFVTTPSKKPPVEPVAATISIGPSISPSSEETIQALETLVSPKLPSLEAPTSASNVMTAFATTPPISSIPPLQEPPRTPSPPLSSHPDIDTDIDSVASQPMELPENLSLEPKDQDSVLLEKDKVNNSSRSKKPKGLELAPTLVITSSDPSPLGILSPSLPTASLTPAFFSQTPIILTPSPLLSSIHFWSTLSPVAPLSPARLQGANTLFQFPSVLNSHGPFTLSGLDGPSTPGPFSPDLQKT
uniprot
proteins
function
FUNCTION: Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. {ECO:0000269|PubMed:22722849}.
uniprot
proteins
mass_dalton
46900
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
1339307
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
22722849
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
8293474
uniprot
proteins
pubmed
9734357
uniprot
proteins
sequence_length
431
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins