Age-related macular degeneration
cv_term_accession
KW-0913
canonical
uniprot_keyword
KW-0913
canonical
name
Age-related macular degeneration
uniprot
synonym
ARMD
uniprot
definition
Protein which, if defective, causes age-related macular degeneration (ARMD), the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch's membrane. ARMD is likely to be a mechanistically heterogeneous group of disorders, and the specific disease mechanisms that underlie the vast majority of cases are currently unknown. However, a number of studies have suggested that both genetic and environmental factors are likely to play a role.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
uniprot_keywords
uniprot
keywords