Ppt1
entrez
29411
canonical
uniprot
P45479
canonical
ensembl
ENSRNOG00000012616
resolver
ensembl
ENSRNOG00055012979
resolver
ensembl
ENSRNOG00060017932
resolver
ensembl
ENSRNOG00065015608
resolver
ensp
ENSRNOP00000091845
resolver
ensp
ENSRNOP00055018057
resolver
ensp
ENSRNOP00060024936
resolver
ensp
ENSRNOP00065020442
resolver
enst
ENSRNOT00055022229
resolver
enst
ENSRNOT00060030796
resolver
enst
ENSRNOT00065025966
resolver
genesymbol
Ppt1
resolver
genesymbol_syn
Cln1
resolver
genesymbol_syn
Ppt
resolver
uniprot
A0JN20
resolver
uniprot_entry
PPT1_RAT
resolver
uniprot_sec
A0JN20
resolver
activity_regulation
ACTIVITY REGULATION: Palmitoylation reduces PPT1 enzymatic activity. {ECO:0000250|UniProtKB:P50897}.
uniprot
proteins
amino_acid_sequence
MASPGYRRLLAAALLPWCCAAWALGHLDPPSPPPLVIWHGMGDSCCNPMSMGSIKKMVEKEIPGIYVLSLEIGKNMVEDVENSFFLNVNLQVGMACQILEKDPKLQHGYNAIGFSQGGQFLRAVAQRCPTPPMMTLISVGGQHQGVFGLPRCPGESSHICDFIRKSLNAGAYSKVVQERLVQAQYWHDPIKEEVYRNCSIFLADINQERHINESYKENLMALKKFVMVKFFNDSIVDPVDSEWFGFYRSGQAKETIPLQETTLYTEDRLGLKKMDKAGKLVFLAKEGDHLQISKEWFTAHIIPFLK
uniprot
proteins
ec_number
3.1.2.2
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
function
FUNCTION: Has thioesterase activity against fatty acid thioesters with 14-18 carbons, including palmitoyl-CoA, S-palmitoyl-N-acetylcysteamine, and palmitoylated proteins. In contrast to PPT2, PPT1 can hydrolyze palmitoylated proteins and palmitoylcysteine. {ECO:0000250|UniProtKB:P50897}.
uniprot
proteins
mass_dalton
34455
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:P45478}.
uniprot
proteins
protein_family
Palmitoyl-protein thioesterase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7916016
uniprot
proteins
sequence_length
306
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:P50897}. Secreted {ECO:0000269|PubMed:7916016}. Golgi apparatus {ECO:0000250|UniProtKB:P50897}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P50897}.
uniprot
proteins