IER5
entrez
51278
canonical
uniprot
Q5VY09
canonical
ensembl
ENSG00000162783
resolver
ensp
ENSP00000356549
resolver
enst
ENST00000367577
resolver
genesymbol
IER5
resolver
hgnc
HGNC:5393
resolver
uniprot
B2RBV3
resolver
uniprot
Q8WY68
resolver
uniprot
Q9NY49
resolver
uniprot
Q9NZP9
resolver
uniprot_entry
IER5_HUMAN
resolver
uniprot_sec
B2RBV3
resolver
uniprot_sec
Q8WY68
resolver
uniprot_sec
Q9NY49
resolver
uniprot_sec
Q9NZP9
resolver
amino_acid_sequence
MEFKLEAHRIVSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSDPCPGLYLAGPAGTPAPPPQQQPGEPAAGPPAGWGEPPPPAARASWPETEPQPERSSVSDAPRVGDEVPVATVTGVGDVFQGGEADATEAAWSRVEGPRQAAAREAEGTAGGWGVFPEVSRAARRPCGCPLGGEDPPGTPAATPRAACCCAPQPAEDEPPAPPAVCPRKRCAAGVGGGPAGCPAPGSTPLKKPRRNLEQPPSGGEDDDAEEMETGNVANLISIFGSSFSGLLRKSPGGGREEEEGEESGPEAAEPGQICCDKPVLRDMNPWSTAIVAF
uniprot
proteins
function
FUNCTION: Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner (PubMed:25355627, PubMed:25816751). Mediates negative transcriptional regulation of CDC25B expression (PubMed:22132193). Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed:19238419, PubMed:22132193). Associates with chromatin to the CDC25B promoter (PubMed:22132193). {ECO:0000269|PubMed:19238419, ECO:0000269|PubMed:22132193, ECO:0000269|PubMed:25355627, ECO:0000269|PubMed:25816751, ECO:0000269|PubMed:26496226}.
uniprot
proteins
mass_dalton
33704
uniprot
proteins
protein_family
IER family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19238419
uniprot
proteins
pubmed
22132193
uniprot
proteins
pubmed
25355627
uniprot
proteins
pubmed
25816751
uniprot
proteins
pubmed
26496226
uniprot
proteins
pubmed
26754925
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25816751}. Cytoplasm {ECO:0000269|PubMed:25816751}. Note=Predominantly cytoplasmic (PubMed:25816751). Translocated in the nucleus during heat shock (PubMed:25816751). {ECO:0000269|PubMed:25816751}.
uniprot
proteins