Tmem119
entrez
231633
canonical
uniprot
Q8R138
canonical
ensembl
ENSMUSG00000054675
resolver
ensp
ENSMUSP00000070551
resolver
ensp
ENSMUSP00000205042
resolver
enst
ENSMUST00000067853
resolver
genesymbol
Tmem119
resolver
uniprot
Q8BP14
resolver
uniprot_entry
TM119_MOUSE
resolver
uniprot_sec
Q8BP14
resolver
amino_acid_sequence
MVPWFLLSLLLLARPVPGVAYSVSLPASFLEDVAGSGEAEGSSASSPSLPPPGTPAFSPTPERPQPTALDGPVPPTNLLEGIMDFFRQYVMLIAVVGSLTFLIMFIVCAALITRQKHKATAYYPSSFPEKKYVDQRDRAGGPRTFSEVPDRAPDSRHEEGLDTSHQLQADILAATQNLRSPARALPGNGEGAKPVKGGSEEEEEEVLSGQEEAQEAPVCGVTEEKLGVPEESVSAEAEGVPATSEGQGEAEGSFSLAQESQGATGPPESPCACNRVSPSV
uniprot
proteins
function
FUNCTION: Plays an important role in bone formation and normal bone mineralization (PubMed:20025746, PubMed:22416756, PubMed:26207632). Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746, PubMed:22416756, PubMed:22579779). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway (PubMed:21239498, PubMed:22579779). Up-regulates the expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451). Essential for normal spermatogenesis and late testicular differentiation (PubMed:26207632). {ECO:0000269|PubMed:20025746, ECO:0000269|PubMed:21239498, ECO:0000269|PubMed:22416756, ECO:0000269|PubMed:22579779, ECO:0000269|PubMed:24362451, ECO:0000269|PubMed:26207632}.
uniprot
proteins
mass_dalton
29401
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="S->A: Loss of glycosylation. No effect on osteoblast mineralization. Loss of glycosylation; when associated with A-43; A-54; A-60 and A-67."; /evidence="ECO:0000269|PubMed:26207632"; MUTAGEN 43; /note="S->A: No loss of glycosylation. Loss of glycosylation; when associated with A-36; A-54; A-60 and A-67."; /evidence="ECO:0000269|PubMed:26207632"; MUTAGEN 54; /note="T->A: No loss of glycosylation. Loss of glycosylation; when associated with A-36; A-43; A-60 and A-67."; /evidence="ECO:0000269|PubMed:26207632"; MUTAGEN 60; /note="T->A: No loss of glycosylation. Loss of glycosylation; when associated with A-36; A-43; A-54 and A-67."; /evidence="ECO:0000269|PubMed:26207632"; MUTAGEN 67; /note="T->A: No loss of glycosylation. Loss of glycosylation; when associated with A-36; A-43; A-54 and A-60."; /evidence="ECO:0000269|PubMed:26207632
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20025746
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21239498
uniprot
proteins
pubmed
22416756
uniprot
proteins
pubmed
22579779
uniprot
proteins
pubmed
24362451
uniprot
proteins
pubmed
26207632
uniprot
proteins
sequence_length
280
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20025746}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:21239498}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21239498}. Secreted {ECO:0000250|UniProtKB:Q4V9L6}.
uniprot
proteins
transmembrane_region
TRANSMEM 92..112; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins