S100B
entrez
6285
canonical
uniprot
P04271
canonical
ensembl
ENSG00000160307
resolver
ensp
ENSP00000291700
resolver
ensp
ENSP00000380769
resolver
ensp
ENSP00000547450
resolver
ensp
ENSP00000547451
resolver
ensp
ENSP00000547452
resolver
ensp
ENSP00000547453
resolver
ensp
ENSP00000547454
resolver
ensp
ENSP00000598899
resolver
ensp
ENSP00000633330
resolver
ensp
ENSP00000633331
resolver
ensp
ENSP00000633332
resolver
enst
ENST00000291700
resolver
enst
ENST00000397648
resolver
enst
ENST00000877391
resolver
enst
ENST00000877392
resolver
enst
ENST00000877393
resolver
enst
ENST00000877394
resolver
enst
ENST00000877395
resolver
enst
ENST00000928840
resolver
enst
ENST00000963271
resolver
enst
ENST00000963272
resolver
enst
ENST00000963273
resolver
genesymbol
S100B
resolver
hgnc
HGNC:10500
resolver
uniprot
A0A0S2Z4C5
resolver
uniprot
D3DSN6
resolver
uniprot_entry
A0A0S2Z4C5_HUMAN
resolver
uniprot_entry
S100B_HUMAN
resolver
uniprot_sec
D3DSN6
resolver
amino_acid_sequence
MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE
uniprot
proteins
function
FUNCTION: Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (PubMed:20950652, PubMed:6487634). Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer (PubMed:20950652, PubMed:6487634). Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites (By similarity). Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation (By similarity). Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue (By similarity). Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase (By similarity). Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (PubMed:20351179). May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (PubMed:22399290). {ECO:0000250|UniProtKB:P02638, ECO:0000250|UniProtKB:P04631, ECO:0000250|UniProtKB:P50114, ECO:0000269|PubMed:20351179, ECO:0000269|PubMed:20950652, ECO:0000269|PubMed:22399290, ECO:0000269|PubMed:6487634}.
uniprot
proteins
mass_dalton
10713
uniprot
proteins
protein_family
S-100 family
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
12480931
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20351179
uniprot
proteins
pubmed
20943659
uniprot
proteins
pubmed
20950652
uniprot
proteins
pubmed
22399290
uniprot
proteins
pubmed
2394738
uniprot
proteins
pubmed
33831707
uniprot
proteins
pubmed
4031854
uniprot
proteins
pubmed
6487634
uniprot
proteins
pubmed
9519411
uniprot
proteins
pubmed
9925766
uniprot
proteins
sequence_length
92
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9925766}. Nucleus {ECO:0000269|PubMed:9925766}. Secreted {ECO:0000250|UniProtKB:P50114}. Note=Secretion into the medium is promoted by interaction with isoform CLSTN3beta of CLSTN3. {ECO:0000250|UniProtKB:P50114}.
uniprot
proteins