FRS3
entrez
10817
canonical
uniprot
O43559
canonical
ensembl
ENSG00000137218
resolver
ensp
ENSP00000259748
resolver
ensp
ENSP00000362109
resolver
ensp
ENSP00000600771
resolver
ensp
ENSP00000600773
resolver
ensp
ENSP00000600774
resolver
ensp
ENSP00000627972
resolver
ensp
ENSP00000627973
resolver
ensp
ENSP00000627974
resolver
enst
ENST00000259748
resolver
enst
ENST00000373018
resolver
enst
ENST00000930712
resolver
enst
ENST00000930714
resolver
enst
ENST00000930715
resolver
enst
ENST00000957913
resolver
enst
ENST00000957914
resolver
enst
ENST00000957915
resolver
genesymbol
FRS3
resolver
hgnc
HGNC:16970
resolver
uniprot
A0A140VJJ7
resolver
uniprot
Q5T3D5
resolver
uniprot_entry
A0A140VJJ7_HUMAN
resolver
uniprot_entry
FRS3_HUMAN
resolver
uniprot_sec
Q5T3D5
resolver
amino_acid_sequence
MGSCCSCLNRDSVPDNHPTKFKVTNVDDEGVELGSGVMELTQSELVLHLHRREAVRWPYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCSRAEEIFNLLQDLMQCNSINVMEEPVIITRNSHPAELDLPRAPQPPNALGYTVSSFSNGCPGEGPRFSAPRRLSTSSLRHPSLGEESTHALIAPDEQSHTYVNTPASEDDHRRGRHCLQPLPEGQAPFLPQARGPDQRDPQVFLQPGQVKFVLGPTPARRHMVKCQGLCPSLHDPPHHNNNNEAPSECPAQPKCTYENVTGGLWRGAGWRLSPEEPGWNGLAHRRAALLHYENLPPLPPVWESQAQQLGGEAGDDGDSRDGLTPSSNGFPDGEEDETPLQKPTSTRAAIRSHGSFPVPLTRRRGSPRVFNFDFRRPGPEPPRQLNYIQVELKGWGGDRPKGPQNPSSPQAPMPTTHPARSSDSYAVIDLKKTVAMSNLQRALPRDDGTARKTRHNSTDLPL
uniprot
proteins
function
FUNCTION: Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2. {ECO:0000269|PubMed:15094036}.
uniprot
proteins
mass_dalton
54462
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB. {ECO:0000250, ECO:0000269|PubMed:15094036, ECO:0000269|PubMed:9660748}.
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15094036
uniprot
proteins
pubmed
15485655
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9660748
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
uniprot
proteins