CD101
entrez
9398
canonical
uniprot
Q93033
canonical
ensembl
ENSG00000134256
resolver
ensp
ENSP00000256652
resolver
ensp
ENSP00000358482
resolver
ensp
ENSP00000508039
resolver
ensp
ENSP00000634397
resolver
enst
ENST00000256652
resolver
enst
ENST00000369470
resolver
enst
ENST00000682167
resolver
genesymbol
CD101
resolver
genesymbol_syn
EWI101
resolver
genesymbol_syn
IGSF2
resolver
genesymbol_syn
V7
resolver
hgnc
HGNC:5949
resolver
uniprot
Q15856
resolver
uniprot_entry
IGSF2_HUMAN
resolver
uniprot_sec
Q15856
resolver
amino_acid_sequence
MAGISYVASFFLLLTKLSIGQREVTVQKGPLFRAEGYPVSIGCNVTGHQGPSEQHFQWSVYLPTNPTQEVQIISTKDAAFSYAVYTQRVRSGDVYVERVQGNSVLLHISKLQMKDAGEYECHTPNTDEKYYGSYSAKTNLIVIPDTLSATMSSQTLGKEEGEPLALTCEASKATAQHTHLSVTWYLTQDGGGSQATEIISLSKDFILVPGPLYTERFAASDVQLNKLGPTTFRLSIERLQSSDQGQLFCEATEWIQDPDETWMFITKKQTDQTTLRIQPAVKDFQVNITADSLFAEGKPLELVCLVVSSGRDPQLQGIWFFNGTEIAHIDAGGVLGLKNDYKERASQGELQVSKLGPKAFSLKIFSLGPEDEGAYRCVVAEVMKTRTGSWQVLQRKQSPDSHVHLRKPAARSVVMSTKNKQQVVWEGETLAFLCKAGGAESPLSVSWWHIPRDQTQPEFVAGMGQDGIVQLGASYGVPSYHGNTRLEKMDWATFQLEITFTAITDSGTYECRVSEKSRNQARDLSWTQKISVTVKSLESSLQVSLMSRQPQVMLTNTFDLSCVVRAGYSDLKVPLTVTWQFQPASSHIFHQLIRITHNGTIEWGNFLSRFQKKTKVSQSLFRSQLLVHDATEEETGVYQCEVEVYDRNSLYNNRPPRASAISHPLRIAVTLPESKLKVNSRSQVQELSINSNTDIECSILSRSNGNLQLAIIWYFSPVSTNASWLKILEMDQTNVIKTGDEFHTPQRKQKFHTEKVSQDLFQLHILNVEDSDRGKYHCAVEEWLLSTNGTWHKLGEKKSGLTELKLKPTGSKVRVSKVYWTENVTEHREVAIRCSLESVGSSATLYSVMWYWNRENSGSKLLVHLQHDGLLEYGEEGLRRHLHCYRSSSTDFVLKLHQVEMEDAGMYWCRVAEWQLHGHPSKWINQASDESQRMVLTVLPSEPTLPSRICSSAPLLYFLFICPFVLLLLLLISLLCLYWKARKLSTLRSNTRKEKALWVDLKEAGGVTTNRREDEEEDEGN
uniprot
proteins
function
FUNCTION: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells. {ECO:0000269|PubMed:11093127, ECO:0000269|PubMed:15737213, ECO:0000269|PubMed:7722299, ECO:0000269|PubMed:9233604, ECO:0000269|PubMed:9389317, ECO:0000269|PubMed:9647226}.
uniprot
proteins
mass_dalton
115109
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:7722299}.
uniprot
proteins
pubmed
10692025
uniprot
proteins
pubmed
11093127
uniprot
proteins
pubmed
11504738
uniprot
proteins
pubmed
15737213
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
7722299
uniprot
proteins
pubmed
7722300
uniprot
proteins
pubmed
9233604
uniprot
proteins
pubmed
9389317
uniprot
proteins
pubmed
9647226
uniprot
proteins
sequence_length
1021
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 955..975; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins