SPPL2B
entrez
56928
canonical
uniprot
Q8TCT7
canonical
ensembl
ENSG00000005206
resolver
ensp
ENSP00000478298
resolver
ensp
ENSP00000478510
resolver
ensp
ENSP00000564125
resolver
ensp
ENSP00000627333
resolver
ensp
ENSP00000627334
resolver
genesymbol
SPPL2B
resolver
genesymbol_syn
IMP4
resolver
genesymbol_syn
KIAA1532
resolver
genesymbol_syn
PSL1
resolver
hgnc
HGNC:30627
resolver
uniprot
D6W609
resolver
uniprot
O60365
resolver
uniprot
Q567S3
resolver
uniprot
Q8IUH9
resolver
uniprot
Q9BUY6
resolver
uniprot
Q9H3M4
resolver
uniprot
Q9NPN2
resolver
uniprot
Q9P1Z6
resolver
uniprot_entry
SPP2B_HUMAN
resolver
uniprot_sec
D6W609
resolver
uniprot_sec
O60365
resolver
uniprot_sec
Q567S3
resolver
uniprot_sec
Q8IUH9
resolver
uniprot_sec
Q9BUY6
resolver
uniprot_sec
Q9H3M4
resolver
uniprot_sec
Q9NPN2
resolver
uniprot_sec
Q9P1Z6
resolver
amino_acid_sequence
MAAAVAAALARLLAAFLLLAAQVACEYGMVHVVSQAGGPEGKDYCILYNPQWAHLPHDLSKASFLQLRNWTASLLCSAADLPARGFSNQIPLVARGNCTFYEKVRLAQGSGARGLLIVSRERLVPPGGNKTQYDEIGIPVALLSYKDMLDIFTRFGRTVRAALYAPKEPVLDYNMVIIFIMAVGTVAIGGYWAGSRDVKKRYMKHKRDDGPEKQEDEAVDVTPVMTCVFVVMCCSMLVLLYYFYDLLVYVVIGIFCLASATGLYSCLAPCVRRLPFGKCRIPNNSLPYFHKRPQARMLLLALFCVAVSVVWGVFRNEDQWAWVLQDALGIAFCLYMLKTIRLPTFKACTLLLLVLFLYDIFFVFITPFLTKSGSSIMVEVATGPSDSATREKLPMVLKVPRLNSSPLALCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRVYFVACTIAYGVGLLVTFVALALMQRGQPALLYLVPCTLVTSCAVALWRRELGVFWTGSGFAKVLPPSPWAPAPADGPQPPKDSATPLSPQPPSEEPATSPWPAEQSPKSRTSEEMGAGAPMREPGSPAESEGRDQAQPSPVTQPGASA
uniprot
proteins
ec_number
3.4.23.-
uniprot
proteins
function
FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829951, PubMed:16829952, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829951, PubMed:16829952). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). {ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:17965014, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:22194595, ECO:0000269|PubMed:23132852}.
uniprot
proteins
mass_dalton
64644
uniprot
proteins
mutagenesis
MUTAGEN 421; /note="D->A: Loss of intramembrane-cleaving activity toward ITM2B, TNF and the simian foamy virus envelope glycoprotein gp130."; /evidence="ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:17965014, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:22194595
uniprot
proteins
post_translational_modification
PTM: Glycosylated (PubMed:15385547, PubMed:15998642). {ECO:0000269|PubMed:15385547, ECO:0000269|PubMed:15998642}.
uniprot
proteins
protein_family
Peptidase A22B family
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
12139484
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15385547
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15998642
uniprot
proteins
pubmed
16829951
uniprot
proteins
pubmed
16829952
uniprot
proteins
pubmed
16873890
uniprot
proteins
pubmed
17965014
uniprot
proteins
pubmed
19114711
uniprot
proteins
pubmed
22194595
uniprot
proteins
pubmed
23132852
uniprot
proteins
sequence_length
592
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16829952}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:17965014}; Multi-pass membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:15998642}; Multi-pass membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:15998642}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:15385547}; Multi-pass membrane protein {ECO:0000305}; Lumenal side {ECO:0000269|PubMed:15385547}. Note=targeted through the entire secretory pathway to endosomes/lysosomes (PubMed:15998642). {ECO:0000269|PubMed:15998642}.
uniprot
proteins
transmembrane_region
TRANSMEM 175..195; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 222..244; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 249..271; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 294..314; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 320..340; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 349..369; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 413..433; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 446..466; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 471..491; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins