PSMC5
entrez
5705
canonical
uniprot
P62195
canonical
ensembl
ENSG00000087191
resolver
ensp
ENSP00000310572
resolver
ensp
ENSP00000364970
resolver
ensp
ENSP00000669370
resolver
genesymbol
PSMC5
resolver
genesymbol_syn
SUG1
resolver
hgnc
HGNC:9552
resolver
uniprot
A0A140VJS3
resolver
uniprot
A8K3Z3
resolver
uniprot
A8K763
resolver
uniprot
O35051
resolver
uniprot
O43208
resolver
uniprot
P47210
resolver
uniprot
P52915
resolver
uniprot
P52916
resolver
uniprot_entry
A0A140VJS3_HUMAN
resolver
uniprot_entry
PRS8_HUMAN
resolver
uniprot_sec
A8K3Z3
resolver
uniprot_sec
A8K763
resolver
uniprot_sec
O35051
resolver
uniprot_sec
O43208
resolver
uniprot_sec
P47210
resolver
uniprot_sec
P52915
resolver
uniprot_sec
P52916
resolver
amino_acid_sequence
MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
uniprot
proteins
disease_involvement
DISEASE: Yu-Kury neurodevelopmental syndrome (YKNS) [MIM:621565]: An autosomal dominant disorder characterized by developmental delay, speech delay, motor delay, and intellectual disability. {ECO:0000269|PubMed:38776958, ECO:0000269|PubMed:40650163, ECO:0000269|PubMed:41298377}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:38776958, PubMed:41298377). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:38776958, ECO:0000269|PubMed:41298377}.
uniprot
proteins
mass_dalton
45626
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
10409732
uniprot
proteins
pubmed
1317798
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15831487
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22078707
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23824326
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25489052
uniprot
proteins
pubmed
26030138
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
38776958
uniprot
proteins
pubmed
40650163
uniprot
proteins
pubmed
41298377
uniprot
proteins
pubmed
7729537
uniprot
proteins
pubmed
7776974
uniprot
proteins
pubmed
9110174
uniprot
proteins
pubmed
9295362
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
uniprot
proteins