Tbc1d24
entrez
224617
canonical
uniprot
Q3UUG6
canonical
ensembl
ENSMUSG00000036473
resolver
ensp
ENSMUSP00000036458
resolver
ensp
ENSMUSP00000094989
resolver
ensp
ENSMUSP00000126107
resolver
ensp
ENSMUSP00000127005
resolver
ensp
ENSMUSP00000128001
resolver
ensp
ENSMUSP00000128868
resolver
ensp
ENSMUSP00000143883
resolver
ensp
ENSMUSP00000144250
resolver
genesymbol
Tbc1d24
resolver
genesymbol_syn
Kiaa1171
resolver
uniprot
A5D6Q7
resolver
uniprot
Q3TTZ8
resolver
uniprot
Q3UH11
resolver
uniprot
Q6ZPW4
resolver
uniprot
Q8BH92
resolver
uniprot
Q8BNF2
resolver
uniprot
Q8C3C6
resolver
uniprot
Q8C3W8
resolver
uniprot_entry
TBC24_MOUSE
resolver
uniprot_sec
A5D6Q7
resolver
uniprot_sec
Q3TTZ8
resolver
uniprot_sec
Q3UH11
resolver
uniprot_sec
Q6ZPW4
resolver
uniprot_sec
Q8BH92
resolver
uniprot_sec
Q8BNF2
resolver
uniprot_sec
Q8C3C6
resolver
uniprot_sec
Q8C3W8
resolver
amino_acid_sequence
MDPPGYNCFVDKDKMDASIQDLGPKELNCTELQELKQLARQGYWAQSHTLRGKVYQRLIRDIPCRTVTPDASVYSDIVGKIVGKHSSSSLPLPEFVDNTQVPTYCLNTRGEGAVRKILLCIANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRILSCNDPTKKLIDQSFLAFESSCMTFGDLVNKYCQAAHKLMVAVSEDVLQVYSDWQRWLFGELPLNYFARVFDVFLVEGYKVLYRVALAILKFFHKVRAGQPLESDNVKQDIRMFVKDIAKTVSPEKLLEKAFAIRLFSRKEIQLLQMANEKALRQKGITVKQKSVSLSKRQFVHLAVHAENFHSEIVSVKEMRDIWSWIPERFALCQPLLLFSSLQHGYSLSRFYFQCEGHEPTLLLIKTTQKEVCGAYLSTDWSERTKFGGKLGFFGTGECFVFRLQPEVQRYEWVVIKHPELTKATSLKSSEAAGSSSLISHCSSDPADRLSPFLAARHFNLPSKTESMFMAGGNDCLIIGGGGGQALYVDGDLNRGRTGHCDTFNNQPLCSENFLIAAVEAWGFQDPDTE
uniprot
proteins
function
FUNCTION: May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515). Involved in neuronal projection development, probably through negative modulation of ARF6 function (PubMed:20727515, PubMed:30335140). Required for the maintenance of postsynaptic neuron dendritic spines in the adult by suppressing ARF6 activity (PubMed:32004315). Involved in the regulation of synaptic vesicle trafficking (PubMed:30335140). Promotes axonal outgrowth and membrane trafficking at the growth cone (By similarity). Positively regulates radial migration and morphological maturation of pyramidal neurons during cortical development by preventing ARF6 activation (By similarity). In one study, has been shown to inhibit the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (By similarity). In another study, has been shown to positively regulate V-ATPase assembly in neurons which promotes acidification of lysosomes and synaptic vesicles (PubMed:39758816). This supports neuronal autophagy and also regulates synaptic vesicle reacidification and the maintenance of the synaptic vesicle reserve pool (PubMed:39758816). Protects neuronal cells against oxidative stress (PubMed:26668325, PubMed:30335140). Involved in the maintainenance of endosomal-mediated vesicle recycling and sustained exocytosis of hair cell ribbon synapses (PubMed:39400345). Facilitates formation of tubular recycling endosomes which promotes recycling of clathrin-independent endocytosis cargo proteins back to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2K5B0, ECO:0000250|UniProtKB:Q9ULP9, ECO:0000269|PubMed:20727515, ECO:0000269|PubMed:26668325, ECO:0000269|PubMed:30335140, ECO:0000269|PubMed:32004315, ECO:0000269|PubMed:39400345, ECO:0000269|PubMed:39758816}.
uniprot
proteins
mass_dalton
63236
uniprot
proteins
mutagenesis
MUTAGEN 178; /note="S->L: Mild hearing loss with accumulation of abnormal endosome-like vacuoles in inner hair cells (IHCs), impaired synaptic vesicle release from IHCs during prolonged stimulus and reduced levels of cochlear Arf6."; /evidence="ECO:0000269|PubMed:39400345"; MUTAGEN 251; /note="F->L: The majority of homozygous knockin mice die prematurely around postnatal day 21, exhibiting spontaneous seizure prior to death, increased excitability of hippocampal neurons, decreased Tbc1d24 protein stability and impaired dendritic spine morphology and excitatory synaptic transmission."; /evidence="ECO:0000269|PubMed:32004315"; MUTAGEN 517; /note="A->V: Increases cellular oxidative stress compared to wild-type. Increases levels of S-nitrosylated proteins in neurons."; /evidence="ECO:0000269|PubMed:26668325
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20727515
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24387994
uniprot
proteins
pubmed
26668325
uniprot
proteins
pubmed
30335140
uniprot
proteins
pubmed
30602030
uniprot
proteins
pubmed
32004315
uniprot
proteins
pubmed
34811399
uniprot
proteins
pubmed
39400345
uniprot
proteins
pubmed
39758816
uniprot
proteins
sequence_length
561
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9ULP9}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9ULP9}. Cytoplasm {ECO:0000250|UniProtKB:Q9ULP9}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9VIH7}; Peripheral membrane protein {ECO:0000305}. Presynapse {ECO:0000269|PubMed:30602030}. Postsynapse {ECO:0000269|PubMed:32004315}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q9ULP9}. Cell projection, dendrite {ECO:0000269|PubMed:32004315}. Perikaryon {ECO:0000269|PubMed:32004315}. Cell projection, growth cone {ECO:0000250|UniProtKB:A0A0G2K5B0}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:30602030}. Note=Mainly cytoplasmic with partial expression at the plasma membrane (By similarity). Associates with certain types of membrane phosphoinositides, preferentially those phosphorylated at the D5 position of the inositol ring such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). In neurons, detected in the cell soma and along neurites (By similarity). Associated with clathrin-coated vesicles and synapses of hippocampal neurons (PubMed:30602030). {ECO:0000250|UniProtKB:Q9ULP9, ECO:0000250|UniProtKB:Q9VIH7, ECO:0000269|PubMed:30602030}.
uniprot
proteins