PPP6C
entrez
5537
canonical
uniprot
O00743
canonical
ensembl
ENSG00000119414
resolver
ensp
ENSP00000362648
resolver
ensp
ENSP00000392147
resolver
ensp
ENSP00000411744
resolver
ensp
ENSP00000559927
resolver
genesymbol
PPP6C
resolver
genesymbol_syn
PPP6
resolver
hgnc
HGNC:9323
resolver
uniprot
A0A024R861
resolver
uniprot
B2R5V6
resolver
uniprot
B7Z2W9
resolver
uniprot
B7Z5K9
resolver
uniprot
Q5U0A2
resolver
uniprot
Q9UIC9
resolver
uniprot_entry
A0A024R861_HUMAN
resolver
uniprot_entry
PPP6_HUMAN
resolver
uniprot_sec
B2R5V6
resolver
uniprot_sec
B7Z2W9
resolver
uniprot_sec
B7Z5K9
resolver
uniprot_sec
Q5U0A2
resolver
uniprot_sec
Q9UIC9
resolver
amino_acid_sequence
MAPLDLDKYVEIARLCKYLPENDLKRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956, PubMed:32474700). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194). During mitosis, regulates spindle positioning (PubMed:27335426). Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228). Also participates in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation (PubMed:29053956). Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 (PubMed:32474700, PubMed:32753499). CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it (PubMed:32474700). {ECO:0000269|PubMed:10227379, ECO:0000269|PubMed:17079228, ECO:0000269|PubMed:17568194, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:29053956, ECO:0000269|PubMed:32474700, ECO:0000269|PubMed:32753499}.
uniprot
proteins
mass_dalton
35144
uniprot
proteins
protein_family
PP-6 (PP-V) subfamily
uniprot
proteins
protein_family
PPP phosphatase family
uniprot
proteins
pubmed
10227379
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16769727
uniprot
proteins
pubmed
17079228
uniprot
proteins
pubmed
17568194
uniprot
proteins
pubmed
18186651
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27335426
uniprot
proteins
pubmed
29053956
uniprot
proteins
pubmed
32474700
uniprot
proteins
pubmed
32753499
uniprot
proteins
pubmed
9013334
uniprot
proteins
pubmed
9647778
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:29053956}. Cytoplasm {ECO:0000269|PubMed:16769727, ECO:0000269|PubMed:17568194}.
uniprot
proteins