Gfra1
entrez
25454
canonical
uniprot
Q62997
canonical
ensembl
ENSRNOG00000017438
resolver
ensembl
ENSRNOG00055028705
resolver
ensembl
ENSRNOG00060018743
resolver
ensembl
ENSRNOG00065010583
resolver
ensp
ENSRNOP00000091515
resolver
ensp
ENSRNOP00055040879
resolver
ensp
ENSRNOP00060026322
resolver
ensp
ENSRNOP00065013110
resolver
enst
ENSRNOT00000104357
resolver
enst
ENSRNOT00055049679
resolver
enst
ENSRNOT00060032311
resolver
enst
ENSRNOT00065017132
resolver
genesymbol
Gfra1
resolver
genesymbol_syn
Gdnfra
resolver
genesymbol_syn
Retl1
resolver
genesymbol_syn
Trnr1
resolver
uniprot
A0ACM8Q1Y9
resolver
uniprot
A6JI55
resolver
uniprot
O35748
resolver
uniprot_entry
A0ACM8Q1Y9_RAT
resolver
uniprot_entry
A6JI55_RAT
resolver
uniprot_entry
GFRA1_RAT
resolver
uniprot_sec
O35748
resolver
amino_acid_sequence
MFLATLYFALPLLDLLMSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNFSLTSGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRAVPFISDVFQQVEHISKGNNCLDAAKACNLDDTCKKYRSAYITPCTTSMSNEVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEERERPNCLSLQDSCKTNYICRSRLADFFTNCQPESRSVSNCLKENYADCLLAYSGLIGTVMTPNYVDSSSLSVAPWCDCSNSGNDLEDCLKFLNFFKDNTCLKNAIQAFGNGSDVTMWQPAPPVQTTTATTTTAFRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGSTHLCLSDSDFGKDGLAGASSHITTKSMAAPPSCSLSSLPVLMLTALAALLSVSLAETS
uniprot
proteins
function
FUNCTION: Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:8674117). GDNF-binding leads to autophosphorylation and activation of the RET receptor (PubMed:25242331, PubMed:8674117). {ECO:0000269|PubMed:25242331, ECO:0000269|PubMed:8674117}.
uniprot
proteins
mass_dalton
51650
uniprot
proteins
protein_family
GDNFR family
uniprot
proteins
pubmed
10719212
uniprot
proteins
pubmed
15044950
uniprot
proteins
pubmed
23333276
uniprot
proteins
pubmed
25242331
uniprot
proteins
pubmed
8657309
uniprot
proteins
pubmed
8674117
uniprot
proteins
pubmed
9177201
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23333276}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:8674117}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:23333276}. Endosome {ECO:0000269|PubMed:23333276}. Endosome, multivesicular body {ECO:0000269|PubMed:23333276}. Note=Localizes mainly to the plasma membrane. In the presence of SORL1, shifts to vesicular structures, including trans-Golgi network, endosomes and multivesicular bodies. {ECO:0000269|PubMed:23333276}.
uniprot
proteins