Psma2
entrez
29669
canonical
uniprot
P17220
canonical
ensembl
ENSRNOG00000049920
resolver
ensembl
ENSRNOG00055011092
resolver
ensembl
ENSRNOG00060014611
resolver
ensembl
ENSRNOG00065018439
resolver
ensp
ENSRNOP00000083039
resolver
ensp
ENSRNOP00055015164
resolver
ensp
ENSRNOP00060019897
resolver
ensp
ENSRNOP00065024667
resolver
enst
ENSRNOT00055018805
resolver
enst
ENSRNOT00060024971
resolver
enst
ENSRNOT00065030966
resolver
genesymbol
Psma2
resolver
uniprot_entry
PSA2_RAT
resolver
amino_acid_sequence
MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVRDYLAAIA
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000250|UniProtKB:P25787}.
uniprot
proteins
mass_dalton
25927
uniprot
proteins
mutagenesis
MUTAGEN 121; /note="Y->F: Abolishes nuclear localization and phosphorylation."; /evidence="ECO:0000269|PubMed:8794741
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues; which may be important for nuclear import. {ECO:0000269|PubMed:8794741}.
uniprot
proteins
protein_family
Peptidase T1A family
uniprot
proteins
pubmed
2335242
uniprot
proteins
pubmed
2340272
uniprot
proteins
pubmed
8794741
uniprot
proteins
sequence_length
234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8794741}. Nucleus {ECO:0000269|PubMed:8794741}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (By similarity). Colocalizes with TRIM5 in cytoplasmic bodies (By similarity). {ECO:0000250|UniProtKB:P25787, ECO:0000250|UniProtKB:P49722}.
uniprot
proteins