NXNL1
entrez
115861
canonical
uniprot
Q96CM4
canonical
ensembl
ENSG00000171773
resolver
ensp
ENSP00000305631
resolver
genesymbol
NXNL1
resolver
genesymbol_syn
Rdcvf
resolver
genesymbol_syn
TXNL6
resolver
hgnc
HGNC:25179
resolver
uniprot
Q0QD37
resolver
uniprot_entry
NXNL1_HUMAN
resolver
uniprot_sec
Q0QD37
resolver
amino_acid_sequence
MASLFSGRILIRNNSDQDELDTEAEVSRRLENRLVLLFFGAGACPQCQAFVPILKDFFVRLTDEFYVLRAAQLALVYVSQDSTEEQQDLFLKDMPKKWLFLPFEDDLRRDLGRQFSVERLPAVVVLKPDGDVLTRDGADEIQRLGTACFANWQEAAEVLDRNFQLPEDLEDQEPRSLTECLRRHKYRVEKAARGGRDPGGGGGEEGGAGGLF
uniprot
proteins
function
FUNCTION: [Isoform 1]: Thioredoxin-like protein that protects retinal rod and cone photoreceptors against oxidative stress and photo-oxidative damage. Plays a role in the inhibition of TAU phosphorylation and protects TAU against oxidative stress in the retina (By similarity). Acts as a reducing system for MSRA, facilitating the repair of oxidized proteins such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS) in the lens during oxidative stress conditions (PubMed:21079812). {ECO:0000250|UniProtKB:Q8VC33, ECO:0000269|PubMed:21079812}.; FUNCTION: [Isoform 2]: Plays an important role in retinal cone photoreceptor survival (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and BSG, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (By similarity). {ECO:0000250|UniProtKB:Q8VC33, ECO:0000269|PubMed:25957687}.
uniprot
proteins
mass_dalton
23943
uniprot
proteins
protein_family
Nucleoredoxin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17249548
uniprot
proteins
pubmed
17286855
uniprot
proteins
pubmed
21079812
uniprot
proteins
pubmed
25957687
uniprot
proteins
sequence_length
212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:21079812}. Mitochondrion {ECO:0000269|PubMed:21079812}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q8VC33}.
uniprot
proteins