Tac4
entrez
282829
canonical
uniprot
Q8CH01
canonical
ensembl
ENSRNOG00055031863
resolver
ensembl
ENSRNOG00060022539
resolver
ensembl
ENSRNOG00065018062
resolver
ensp
ENSRNOP00055045593
resolver
ensp
ENSRNOP00060032325
resolver
ensp
ENSRNOP00065024036
resolver
enst
ENSRNOT00055055154
resolver
enst
ENSRNOT00060039093
resolver
enst
ENSRNOT00065030253
resolver
genesymbol
Tac4
resolver
uniprot_entry
TKN4_RAT
resolver
amino_acid_sequence
MLPLLALFLLIGPAVSTTTRDREDLTFGAEAESWVTVNLKGIPVPSIELKLQELKRSRTRQFYGLMGKRVEGVHPIQSAERTGYQLGRIVQDLLGTRGLSIEGSCRQETNHQSAGPGAVARESLQSQRGRSEPPNHQQHVALSLGTEEDDQSSERAPRDASQMMPRPSRP
uniprot
proteins
function
FUNCTION: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Hemokinin induces plasma extravasation, mast cell degranulation, muscle contraction, salivary secretion and scratching behavior. Increases sperm motility. Induces potent analgesic effects and may play a role in pain modulation. Promotes survival of bone marrow B lineage cells and of cultured LPS-stimulated pre-B cells and may act as an autocrine factor required for B-cell survival and proliferation. Lowers systemic arterial pressure following intravenous injection. Induces interferon-gamma production and may play a role in the inflammatory response. Shows potent affinity and specificity for the NK-1 receptor. {ECO:0000269|PubMed:11786503, ECO:0000269|PubMed:12044836, ECO:0000269|PubMed:16102736, ECO:0000269|PubMed:17628523}.
uniprot
proteins
mass_dalton
18751
uniprot
proteins
protein_family
Tachykinin family
uniprot
proteins
pubmed
11786503
uniprot
proteins
pubmed
12044836
uniprot
proteins
pubmed
12383518
uniprot
proteins
pubmed
16102736
uniprot
proteins
pubmed
17628523
uniprot
proteins
sequence_length
170
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins