Ndufs2
entrez
226646
canonical
uniprot
Q91WD5
canonical
ensembl
ENSMUSG00000013593
resolver
ensp
ENSMUSP00000013737
resolver
ensp
ENSMUSP00000106950
resolver
ensp
ENSMUSP00000195401
resolver
enst
ENSMUST00000013737
resolver
enst
ENSMUST00000111318
resolver
genesymbol
Ndufs2
resolver
uniprot
D3YXT0
resolver
uniprot
Q3TNA8
resolver
uniprot
Q3U5Y9
resolver
uniprot
Q3UJX7
resolver
uniprot
Q99L23
resolver
uniprot_entry
D3YXT0_MOUSE
resolver
uniprot_entry
NDUS2_MOUSE
resolver
uniprot_sec
Q3TNA8
resolver
uniprot_sec
Q3U5Y9
resolver
uniprot_sec
Q3UJX7
resolver
uniprot_sec
Q99L23
resolver
amino_acid_sequence
MAALRALRCLRGVGAPVLRPGSGIRLPSQPSRGARQWQPDIEWAEQFSGAVMYPSKETAHWKPPPWNDVDILKEKAVTNMTLNFGPQHPAAHGVLRLVLELSGEMVRKCDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSIAVEKLLNIQPPPRAQWIRVLFGEITRILNHIMAVTTHALDIGAMTPFFWMFEEREKMFEFYERVSGARMHAAYIRPGGVHQDLPLGLLDDIYEFSKNFSLRIDEVEEMLTNNRIWRNRTVDIGVVTAEDALNYGFSGVMLRGSGIQWDLRKTQPYDVYDQVEFDVPIGSRGDCYDRYLCRVEEMRQSLRIIEQCLNKMPPGEIKVDDAKVSPPKRAEMKTSMESLIHHFKLYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPYRCKIKAPGFAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEIDR
uniprot
proteins
ec_number
7.1.1.2
uniprot
proteins
function
FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:26437605, PubMed:29887397, PubMed:31297047, PubMed:38575788). Essential for the catalytic activity and assembly of complex I (PubMed:26437605, PubMed:29887397, PubMed:31297047). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (PubMed:30922174). Plays an important role in carotid body sensing of hypoxia (PubMed:26437605, PubMed:29887397). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (PubMed:31297047). {ECO:0000269|PubMed:26437605, ECO:0000269|PubMed:29887397, ECO:0000269|PubMed:30922174, ECO:0000269|PubMed:31297047, ECO:0000269|PubMed:38575788}.
uniprot
proteins
mass_dalton
52626
uniprot
proteins
post_translational_modification
PTM: Dimethylation at Arg-118 by NDUFAF7 takes place after NDUFS2 assembles into the complex I, leading to stabilize the early intermediate complex. {ECO:0000250|UniProtKB:O75306}.
uniprot
proteins
protein_family
Complex I 49 kDa subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
26437605
uniprot
proteins
pubmed
29887397
uniprot
proteins
pubmed
30922174
uniprot
proteins
pubmed
31297047
uniprot
proteins
pubmed
32279995
uniprot
proteins
pubmed
38575788
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:38575788}; Peripheral membrane protein {ECO:0000269|PubMed:38575788}; Matrix side {ECO:0000269|PubMed:38575788}.
uniprot
proteins