Cd14
entrez
60350
canonical
uniprot
Q63691
canonical
ensembl
ENSRNOG00000017819
resolver
ensembl
ENSRNOG00065013294
resolver
ensp
ENSRNOP00000023977
resolver
ensp
ENSRNOP00065016924
resolver
enst
ENSRNOT00065021846
resolver
genesymbol
Cd14
resolver
uniprot
Q6GT04
resolver
uniprot_entry
CD14_RAT
resolver
uniprot_sec
Q6GT04
resolver
amino_acid_sequence
MKLMLGLLLLPLTLVHASPATPEPCELDQDEESVRCYCNFSDPQPNWSSAFLCAGAEDVEFYGGGRSLEYLLKRVDTEANLGQYTDIIRSLPLKRLTVRSARVPTQILFGTLRVLGYSGLRELTLENLEVTGTALSPLLDATGPDLNTLSLRNVSWATTDTWLAELQQWLKPGLKVLSIAQAHSLNFSCKQVGVFPALATLDLSDNPELGEKGLISALCPHKFPTLQVLALRNAGMETTSGVCSALAAARVPLQALDLSHNSLRDTAGTPSCDWPSQLNSLNLSFTGLEHVPKGLPAKLSVLDLSYNRLDRKPRPEELPEVGSLSLTGNPFLHSESQSEAYNSGVVIATALSPGSAGLSGTLALLLGHRLFV
uniprot
proteins
function
FUNCTION: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity). {ECO:0000250|UniProtKB:P08571, ECO:0000250|UniProtKB:P10810}.
uniprot
proteins
mass_dalton
40054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8598386
uniprot
proteins
pubmed
9201265
uniprot
proteins
pubmed
9784508
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08571}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P08571}. Secreted {ECO:0000250|UniProtKB:P08571}. Membrane raft {ECO:0000250|UniProtKB:P08571}. Golgi apparatus {ECO:0000250|UniProtKB:P08571}. Note=Soluble, secreted forms seem to exist. They may arise by cleavage of the GPI anchor. {ECO:0000250|UniProtKB:P08571}.
uniprot
proteins