Pafah1b2
entrez
18475
canonical
uniprot
Q61206
canonical
ensembl
ENSMUSG00000003131
resolver
ensp
ENSMUSP00000127851
resolver
ensp
ENSMUSP00000149819
resolver
ensp
ENSMUSP00000151196
resolver
ensp
ENSMUSP00000267709
resolver
ensp
ENSMUSP00000267716
resolver
ensp
ENSMUSP00000267717
resolver
ensp
ENSMUSP00000360960
resolver
enst
ENSMUST00000172450
resolver
enst
ENSMUST00000214179
resolver
genesymbol
Pafah1b2
resolver
genesymbol_syn
Pafahb
resolver
uniprot
Q6PKE6
resolver
uniprot
Q7TNP3
resolver
uniprot_entry
PA1B2_MOUSE
resolver
uniprot_sec
Q6PKE6
resolver
uniprot_sec
Q7TNP3
resolver
activity_regulation
ACTIVITY REGULATION: Beta subunit (PAFAH1B1) stimulates the acetylhydrolase activity of the alpha2/alpha2 catalytic homodimer. {ECO:0000250|UniProtKB:P68401}.
uniprot
proteins
amino_acid_sequence
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLLKVSLPKLANVQLLDIDGGFVHSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLEETPEEKQTTIA
uniprot
proteins
ec_number
3.1.1.47
uniprot
proteins
function
FUNCTION: Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (PubMed:12775763). {ECO:0000250|UniProtKB:P68401, ECO:0000269|PubMed:12775763}.
uniprot
proteins
mass_dalton
25581
uniprot
proteins
protein_family
'GDSL' lipolytic enzyme family
uniprot
proteins
protein_family
Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily
uniprot
proteins
pubmed
12775763
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17330141
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8954729
uniprot
proteins
sequence_length
229
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins