Bcl11b
entrez
58208
canonical
uniprot
Q99PV8
canonical
ensembl
ENSMUSG00000048251
resolver
ensp
ENSMUSP00000068258
resolver
ensp
ENSMUSP00000105513
resolver
ensp
ENSMUSP00000105517
resolver
ensp
ENSMUSP00000257488
resolver
ensp
ENSMUSP00000257489
resolver
ensp
ENSMUSP00000257490
resolver
ensp
ENSMUSP00000257491
resolver
enst
ENSMUST00000109887
resolver
genesymbol
Bcl11b
resolver
genesymbol_syn
Ctip2
resolver
genesymbol_syn
Rit1
resolver
uniprot
A0A0R4J1E1
resolver
uniprot
Q8C2I1
resolver
uniprot
Q99PV6
resolver
uniprot
Q99PV7
resolver
uniprot
Q9JLF8
resolver
uniprot_entry
A0A0R4J1E1_MOUSE
resolver
uniprot_entry
BC11B_MOUSE
resolver
uniprot_sec
Q8C2I1
resolver
uniprot_sec
Q99PV6
resolver
uniprot_sec
Q99PV7
resolver
uniprot_sec
Q9JLF8
resolver
amino_acid_sequence
MSRRKQGNPQHLSQRELITPEADHVEATILEEDEGLEIEEPSSLGLMVGGPDPDLLTCGQCQMNFPLGDILVFIEHKKKQCGGLGPCYDKVLDKSSPPPSSRSELRRVSEPVEIGIQVTPDEDDHLLSPTKGICPKQENIAGPCRPAQLPSMAPIAASSSHPPTSVITSPLRALGVLPPCFPLPCCGARPISGDGTQGEGQMEAPFGCQCELSGKDEPSSYICTTCKQPFNSAWFLLQHAQNTHGFRIYLEPGPASTSLTPRLTIPPPLGPETVAQSPLMNFLGDSNPFNLLRMTGPILRDHPGFGEGRLPGTPPLFSPPPRHHLDPHRLSAEEMGLVAQHPSAFDRVMRLNPMAIDSPAMDFSRRLRELAGNSSTPPPVSPGRGNPMHRLLNPFQPSPKSPFLSTPPLPPMPAGTPPPQPPAKSKSCEFCGKTFKFQSNLIVHRRSHTGEKPYKCQLCDHACSQASKLKRHMKTHMHKAGSLAGRSDDGLSAASSPEPGTSELPGDLKAADGDFRHHESDPSLGPEPEDDEDEEEEEEELLLENESRPESSFSMDSELGRGRENGGGVPPGVAGAGAAAAALADEKALALGKVMEDAGLGALPQYGEKRGAFLKRAGDTGDAGAVGCGDAGAPGAVNGRGGAFAPGAEPFPALFPRKPAPLPSPGLGGPALHAAKRIKVEKDLELPPAALIPSENVYSQWLVGYAASRHFMKDPFLGFTDARQSPFATSSEHSSENGSLRFSTPPGDLLDGGLSGRSGTASGGSTPHLGGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQIGKEVYRCDICQMPFSVYSTLEKHMKKWHGEHLLTNDVKIEQAERS
uniprot
proteins
function
FUNCTION: Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals (PubMed:12717433). Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (By similarity). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element. {ECO:0000250|UniProtKB:Q9C0K0, ECO:0000269|PubMed:12717433, ECO:0000269|PubMed:16809611}.
uniprot
proteins
mass_dalton
94566
uniprot
proteins
post_translational_modification
PTM: Sumoylated with SUMO1. {ECO:0000269|PubMed:23213215}.
uniprot
proteins
pubmed
10744719
uniprot
proteins
pubmed
12565905
uniprot
proteins
pubmed
12717433
uniprot
proteins
pubmed
12930829
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16809611
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23213215
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
884
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins