Nop58
entrez
60373
canonical
uniprot
Q9QZ86
canonical
ensembl
ENSRNOG00000016486
resolver
ensembl
ENSRNOG00055023889
resolver
ensembl
ENSRNOG00060019139
resolver
ensembl
ENSRNOG00065027245
resolver
ensp
ENSRNOP00000022676
resolver
ensp
ENSRNOP00055033341
resolver
ensp
ENSRNOP00060027195
resolver
ensp
ENSRNOP00065038627
resolver
enst
ENSRNOT00000022676
resolver
enst
ENSRNOT00055041011
resolver
enst
ENSRNOT00060033227
resolver
enst
ENSRNOT00065047088
resolver
genesymbol
Nop58
resolver
genesymbol_syn
Nap65
resolver
genesymbol_syn
Nol5
resolver
genesymbol_syn
Nop5
resolver
uniprot
O88525
resolver
uniprot_entry
NOP58_RAT
resolver
uniprot_sec
O88525
resolver
amino_acid_sequence
MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAFTALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIRSQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASATLSEFLSEEVEAEVKAAAEISMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIAHAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGAENRAKLEARLRILEDRGIRKISGTGKALAKAEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEEVDKEDEITEKKAKKAKIKIKAEVEEEMEEAEEEQVVEEEPTVKKKKKKDKKKHIKEEPLSEEEPCTSTAVPSPEKKKKKKKKKDAED
uniprot
proteins
function
FUNCTION: Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs). {ECO:0000250|UniProtKB:Q9Y2X3}.
uniprot
proteins
mass_dalton
60071
uniprot
proteins
post_translational_modification
PTM: Sumoylation is essential for high-affinity binding to snoRNAs. {ECO:0000250|UniProtKB:Q9Y2X3}.
uniprot
proteins
protein_family
NOP5/NOP56 family
uniprot
proteins
pubmed
10679015
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
534
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9Y2X3}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9Y2X3}. Note=Localizes to the nucleolus with a minor part present in the nucleoplasm. {ECO:0000250|UniProtKB:Q9Y2X3}.
uniprot
proteins