CCDC85B
entrez
11007
canonical
uniprot
Q15834
canonical
ensembl
ENSG00000175602
resolver
ensp
ENSP00000311695
resolver
enst
ENST00000312579
resolver
genesymbol
CCDC85B
resolver
genesymbol_syn
DIPA
resolver
hgnc
HGNC:24926
resolver
uniprot
B2R598
resolver
uniprot
Q96HA0
resolver
uniprot_entry
CC85B_HUMAN
resolver
uniprot_sec
B2R598
resolver
uniprot_sec
Q96HA0
resolver
amino_acid_sequence
MEAEAGGLEELTDEEMAALGKEELVRRLRREEAARLAALVQRGRLMQEVNRQLQGHLGEIRELKQLNRRLQAENRELRDLCCFLDSERQRGRRAARQWQLFGTQASRAVREDLGGCWQKLAELEGRQEELLRENLALKELCLALGEEWGPRGGPSGAGGSGAGPAPELALPPCGPRDLGDGSSSTGSVGSPDQLPLACSPDD
uniprot
proteins
function
FUNCTION: Functions as a transcriptional repressor (PubMed:17014843). May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (PubMed:17873903). May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (By similarity). Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). {ECO:0000250|UniProtKB:A2CEM9, ECO:0000250|UniProtKB:Q6PDY0, ECO:0000269|PubMed:17014843, ECO:0000269|PubMed:17873903}.; FUNCTION: (Microbial infection) Plays a role in hepatitis delta virus (HDV) genomic replication. {ECO:0000269|PubMed:8810253}.
uniprot
proteins
mass_dalton
22091
uniprot
proteins
mutagenesis
MUTAGEN 131; /note="L->A: Loss of interaction with TCF7L2 and loss of suppression of CTNNB1 activity. Loss of cell growth inhibition."; /evidence="ECO:0000269|PubMed:17873903
uniprot
proteins
protein_family
CCDC85 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17014843
uniprot
proteins
pubmed
17873903
uniprot
proteins
pubmed
22666460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25009281
uniprot
proteins
pubmed
8810253
uniprot
proteins
sequence_length
202
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17014843, ECO:0000269|PubMed:17873903}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17014843}. Cell junction, adherens junction {ECO:0000269|PubMed:25009281}.
uniprot
proteins