Plpp3
entrez
67916
canonical
uniprot
Q99JY8
canonical
ensembl
ENSMUSG00000028517
resolver
ensp
ENSMUSP00000065719
resolver
enst
ENSMUST00000064139
resolver
genesymbol
Plpp3
resolver
genesymbol_syn
Lpp3
resolver
genesymbol_syn
Ppap2b
resolver
uniprot
Q3TVM4
resolver
uniprot
Q3TXR7
resolver
uniprot
Q8BTB7
resolver
uniprot_entry
PLPP3_MOUSE
resolver
uniprot_sec
Q3TVM4
resolver
uniprot_sec
Q3TXR7
resolver
uniprot_sec
Q8BTB7
resolver
activity_regulation
ACTIVITY REGULATION: Magnesium-independent phospholipid phosphatase. Insensitive to N-ethylmaleimide. {ECO:0000250|UniProtKB:O14495}.
uniprot
proteins
amino_acid_sequence
MQSYKYDKAIVPESKNGGSPALNNNPRKGGSKRVLLICLDLFCLFMAALPFLIIETSTIKPYRRGFYCNDESIKYPLKVSETINDAVLCAVGIVIAILAIITGEFYRIYYLKEKSRSTTQNPYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCDPDFSQINCSEGYIQNYRCRGEDSKVQEARKSFFSGHASFSMFTMLYLVLYLQARFTWRGARLLRPLLQFTLLMMAFYTGLSRVSDYKHHPSDVLAGFAQGALVACCIVFFVSDLFKTKTSLSLPAPAIRREILSPVDIIDRNNHHNMV
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
ec_number
3.1.3.4
uniprot
proteins
function
FUNCTION: Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines (By similarity). By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function (PubMed:21319224). Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers (By similarity). {ECO:0000250|UniProtKB:O14495, ECO:0000269|PubMed:21319224}.; FUNCTION: Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth (PubMed:12925589, PubMed:27125875). Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis (PubMed:16099422). {ECO:0000269|PubMed:12925589, ECO:0000269|PubMed:16099422, ECO:0000269|PubMed:27125875}.
uniprot
proteins
mass_dalton
35216
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000269|PubMed:12925589, ECO:0000269|PubMed:21319224}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Contains high-mannose oligosaccharides. {ECO:0000250|UniProtKB:O14495}.
uniprot
proteins
protein_family
PA-phosphatase related phosphoesterase family
uniprot
proteins
pubmed
12925589
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16099422
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17610274
uniprot
proteins
pubmed
19123136
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21319224
uniprot
proteins
pubmed
27125875
uniprot
proteins
pubmed
29889835
uniprot
proteins
sequence_length
312
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16099422, ECO:0000269|PubMed:21319224}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Basolateral cell membrane {ECO:0000250|UniProtKB:O14495}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O14495}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:O14495}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O14495}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:O14495}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Membrane raft {ECO:0000250|UniProtKB:O14495}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97544}. Note=Cycles between the endoplasmic reticulum and the Golgi. {ECO:0000250|UniProtKB:O14495}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 86..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 124..144; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 195..215; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 227..244; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 259..279; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins