Rgr
entrez
57811
canonical
uniprot
Q9Z2B3
canonical
ensembl
ENSMUSG00000021804
resolver
ensp
ENSMUSP00000022338
resolver
enst
ENSMUST00000022338
resolver
genesymbol
Rgr
resolver
uniprot
Q543X1
resolver
uniprot_entry
Q543X1_MOUSE
resolver
uniprot_entry
RGR_MOUSE
resolver
amino_acid_sequence
MAATRALPAGLGELEVLAVGTVLLMEALSGISLNGLTIFSFCKTPDLRTPSNLLVLSLALADTGISLNALVAAVSSLLRRWPHGSEGCQVHGFQGFATALASICGSAAVAWGRYHHYCTRRQLAWDTAIPLVLFVWMSSAFWASLPLMGWGHYDYEPVGTCCTLDYSRGDRNFISFLFTMAFFNFLVPLFITHTSYRFMEQKFSRSGHLPVNTTLPGRMLLLGWGPYALLYLYAAIADVSFISPKLQMVPALIAKTMPTINAINYALHREMVCRGTWQCLSPQKSKKDRTQ
uniprot
proteins
function
FUNCTION: Non-visual opsin that functions as a light-dependent facilitator of retinoid isomerization and trafficking in retinal pigment epithelium (RPE) and Mueller glia (PubMed:11431696). Participates in a photic visual cycle by complementing the classical enzymatic RPE65/RDH pathway for chromophore regeneration (PubMed:11431696, PubMed:12716426). Binds all-trans-retinal via a conserved Schiff-base lysine and, upon illumination, promotes photoisomerization of all-trans-retinal to 11-cis-retinal required for regeneration of visual pigments (PubMed:11431696, PubMed:15961402). Also mediates light-dependent mobilization of stored all-trans-retinyl esters from lipid droplets to endoplasmic reticulum membranes, facilitating their processing into 11-cis-retinoids (PubMed:18474598). May also modulate isomerohydrolase activity independent of light (PubMed:15961402). Although RGR is structurally a GPCR-family opsin, there is no consistent evidence that RGR activates G proteins or initiates a canonical second-messenger signaling cascade (Probable). {ECO:0000269|PubMed:11431696, ECO:0000269|PubMed:12716426, ECO:0000269|PubMed:15961402, ECO:0000269|PubMed:18474598, ECO:0000305}.
uniprot
proteins
mass_dalton
32127
uniprot
proteins
post_translational_modification
PTM: Contains a covalently bound retinal chromophore linked via a Schiff base to a conserved lysine, and can bind both all-trans-retinal and 11-cis-retinal (By similarity). Upon illumination, mediates photoisomerization of all-trans-retinal to 11-cis-retinal (By similarity). {ECO:0000250|UniProtKB:P47804}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Opsin subfamily
uniprot
proteins
pubmed
11431696
uniprot
proteins
pubmed
12716426
uniprot
proteins
pubmed
15961402
uniprot
proteins
pubmed
18474598
uniprot
proteins
pubmed
9841934
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:18474598}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 131..151; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 176..196; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 220..240; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 248..268; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins