FRS2
entrez
10818
canonical
uniprot
Q8WU20
canonical
ensembl
ENSG00000166225
resolver
ensp
ENSP00000381083
resolver
ensp
ENSP00000447241
resolver
ensp
ENSP00000450048
resolver
ensp
ENSP00000542675
resolver
ensp
ENSP00000542676
resolver
ensp
ENSP00000542677
resolver
ensp
ENSP00000542678
resolver
ensp
ENSP00000542679
resolver
ensp
ENSP00000542680
resolver
ensp
ENSP00000542681
resolver
ensp
ENSP00000604364
resolver
ensp
ENSP00000604365
resolver
ensp
ENSP00000604366
resolver
ensp
ENSP00000604367
resolver
ensp
ENSP00000604368
resolver
ensp
ENSP00000618237
resolver
ensp
ENSP00000618238
resolver
ensp
ENSP00000618239
resolver
enst
ENST00000397997
resolver
enst
ENST00000549921
resolver
enst
ENST00000550389
resolver
enst
ENST00000872616
resolver
enst
ENST00000872617
resolver
enst
ENST00000872618
resolver
enst
ENST00000872619
resolver
enst
ENST00000872620
resolver
enst
ENST00000872621
resolver
enst
ENST00000872622
resolver
enst
ENST00000934305
resolver
enst
ENST00000934306
resolver
enst
ENST00000934307
resolver
enst
ENST00000934308
resolver
enst
ENST00000934309
resolver
enst
ENST00000948178
resolver
enst
ENST00000948179
resolver
enst
ENST00000948180
resolver
genesymbol
FRS2
resolver
hgnc
HGNC:16971
resolver
uniprot
B0LPF2
resolver
uniprot
B2R684
resolver
uniprot
O43558
resolver
uniprot
Q7LDQ6
resolver
uniprot_entry
FRS2_HUMAN
resolver
uniprot_sec
B0LPF2
resolver
uniprot_sec
B2R684
resolver
uniprot_sec
O43558
resolver
uniprot_sec
Q7LDQ6
resolver
amino_acid_sequence
MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDPQILLEPEGVKFVLGPTPVQKQLMEKEKLEQLGRDQVSGSGANNTEWDTGYDSDERRDAPSVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRTALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTVPASAHKIEYSRRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM
uniprot
proteins
function
FUNCTION: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}.
uniprot
proteins
mass_dalton
57029
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases; this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases. {ECO:0000250, ECO:0000269|PubMed:10092678, ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:17274988, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:9660748}.; PTM: Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
10092678
uniprot
proteins
pubmed
11090629
uniprot
proteins
pubmed
12974390
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15488758
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17274988
uniprot
proteins
pubmed
18452557
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20094046
uniprot
proteins
pubmed
21765395
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9660748
uniprot
proteins
sequence_length
508
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system. Note=Cytoplasmic, membrane-bound.
uniprot
proteins