Q99P55
uniprot
Q99P55
canonical
amino_acid_sequence
MSLGQRLALLAIRLQEPQRVASFQRLCGVEVPLGSPKAGEDAETEVRGAPGDPRRRPRQSGADGSPAKPDCCGAPNGVRNGLAAEPGPTGPRRAGSLRRNSLTGEEGELAKVSNLPLYYLFCFGTELGNELFYIIFFPFWIWNLDPFVGRRLVIIWVLVMYLGQCTKDIIRWPRPASPPVIKLEIFYNSEYSMPSTHAMSGTAIPIAMILLTYGRWQYPLIYGLILIPCWSSLVCLSRIYMGMHSILDVIAGFLYTILILIIFYPLVDLIDNFNQTYKYAPLIIIGLHLILGIFSFTLDTWSTSRGDTAEILGSGAGIACGSHAAYNLGISLDPSLHTLPLAIPPLTVTLFGKAILRVVIGMLLVLFVRDIMKKVTIPLACKLFGIPCHDLRQARQHMEVELPYRYITYGTVGFSITFLIPYIFSFIGIS
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
function
FUNCTION: Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid. Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway. Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (By similarity). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus (By similarity). The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries. Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (By similarity). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q9BX95, ECO:0000250|UniProtKB:Q9JI99}.
uniprot
proteins
mass_dalton
47649
uniprot
proteins
protein_family
Type 2 lipid phosphate phosphatase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
430
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BX95}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9JI99}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 121..141; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 152..172; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 216..236; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 246..266; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 279..299; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 348..368; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 409..429; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins