FAM83B
entrez
222584
canonical
uniprot
Q5T0W9
canonical
ensembl
ENSG00000168143
resolver
ensp
ENSP00000304078
resolver
ensp
ENSP00000711214
resolver
ensp
ENSP00000748013
resolver
enst
ENST00000306858
resolver
genesymbol
FAM83B
resolver
genesymbol_syn
C6orf143
resolver
hgnc
HGNC:21357
resolver
uniprot
Q2M1P3
resolver
uniprot
Q96DQ2
resolver
uniprot_entry
FA83B_HUMAN
resolver
uniprot_sec
Q2M1P3
resolver
uniprot_sec
Q96DQ2
resolver
amino_acid_sequence
METSSMLSSLNDECKSDNYIEPHYKEWYRVAIDILIEHGLEAYQEFLVQERVSDFLAEEEINYILKNVQKVAQSTAHGTDDSCDDTLSSGTYWPVESDVEAPNLDLGWPYVMPGLLGGTHIDLLFHPPRAHLLTIKETIRKMIKEARKVIALVMDIFTDVDIFKEIVEASTRGVSVYILLDESNFNHFLNMTEKQGCSVQRLRNIRVRTVKGQDYLSKTGAKFHGKMEQKFLLVDCQKVMYGSYSYMWSFEKAHLSMVQIITGQLVESFDEEFRTLYARSCVPSSFAQEESARVKHGKALWENGTYQHSVSSLASVSSQRNLFGRQDKIHKLDSSYFKNRGIYTLNEHDKYNIRSHGYKPHFVPNFNGPNAIRQFQPNQINENWKRHSYAGEQPETVPYLLLNRALNRTNNPPGNWKKPSDSLSVASSSREGYVSHHNTPAQSFANRLAQRKTTNLADRNSNVRRSFNGTDNHIRFLQQRMPTLEHTTKSFLRNWRIESYLNDHSEATPDSNGSALGDRFEGYDNPENLKANALYTHSRLRSSLVFKPTLPEQKEVNSCTTGSSNSTIIGSQGSETPKEVPDTPTNVQHLTDKPLPESIPKLPLQSEAPKMHTLQVPENHSVALNQTTNGHTESNNYIYKTLGVNKQTENLKNQQTENLLKRRSFPLFDNSKANLDPGNSKHYVYSTLTRNRVRQPEKPKEDLLKSSKSMHNVTHNLEEDEEEVTKRNSPSGTTTKSVSIAALLDVNKEESNKELASKKEVKGSPSFLKKGSQKLRSLLSLTPDKKENLSKNKAPAFYRLCSSSDTLVSEGEENQKPKKSDTKVDSSPRRKHSSSSNSQGSIHKSKEDVTVSPSQEINAPPDENKRTPSPGPVESKFLERAGDASAPRFNTEQIQYRDSREINAVVTPERRPTSSPRPTSSELLRSHSTDRRVYSRFEPFCKIESSIQPTSNMPNTSINRPEIKSATMGNSYGRSSPLLNYNTGVYRSYQPNENKFRGFMQKFGNFIHKNK
uniprot
proteins
function
FUNCTION: Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}.
uniprot
proteins
mass_dalton
114799
uniprot
proteins
mutagenesis
MUTAGEN 230; /note="K->A: Loss of interaction with EGFR. Loss of activation of EGFR."; /evidence="ECO:0000269|PubMed:23912460
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in vitro by CSNK1A1. {ECO:0000269|PubMed:29789297}.
uniprot
proteins
protein_family
SACK1 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22886302
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23676467
uniprot
proteins
pubmed
23912460
uniprot
proteins
pubmed
29789297
uniprot
proteins
sequence_length
1011
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22886302}. Membrane {ECO:0000269|PubMed:22886302}.
uniprot
proteins