Lima1
entrez
65970
canonical
uniprot
Q9ERG0
canonical
ensembl
ENSMUSG00000023022
resolver
ensp
ENSMUSP00000073371
resolver
ensp
ENSMUSP00000104652
resolver
genesymbol
Lima1
resolver
genesymbol_syn
D15Ertd366e
resolver
genesymbol_syn
Eplin
resolver
uniprot
Q8C3R7
resolver
uniprot
Q8CD09
resolver
uniprot
Q8K2H0
resolver
uniprot
Q9ERG1
resolver
uniprot_entry
LIMA1_MOUSE
resolver
uniprot_entry
Q8C3R7_MOUSE
resolver
uniprot_entry
Q8CD09_MOUSE
resolver
uniprot_sec
Q8K2H0
resolver
uniprot_sec
Q9ERG1
resolver
amino_acid_sequence
MESTPFNRRQWTSLSLRVTAKELSLVNKNKSSAIVEIFSKYQKAAEEANMERKKNNPESLPQHFRRGTLSVLKKKWENPVAGAEFHTDSLPNSSSEGGHTADYPPAEVTDKPAPGVRADREEHTQPKPRFGSRPEAVIQSRYPRSENSHDFKAQATESQKMENCLGDSRHEAEKPETSENTETSGKIEKYNVPLNRLKMMFEKGEHNQTKSLWTQSRNAGGRRLSENNCSLDDWEIGAGHLSSSAFNSEKNESKRNLELPRLSETSIKDRMAKYQAAVSKQSSPASYTNELKTSESKTHKWEQKENVPPGPEACSVHQEGSKVSTTENSLVALSVPAEDDTCNSQVKSEAQQPMHPKPLSPDARTSSLPESSPSKTAKKFQAPAKESCVECQKTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHFNQLFKSKGNYDEGFGHKQHKDLWASKSDNEETLGRPAQPPNAGESPHSPGVEDAPIAKVGVLAASMEAKASSQREREDKPAETKKLRIAWPPPAELGGSGSALEEGIKVSKPKWPPEDDVCKTEAPEDVDLDLKKLRRSSSLKERSRPFTVAASFRTSSIKSPKASSPSLRKGWSESEQSEEFGGGIATMERKQTENARPSGEKENVGKSRWQGEEVPRSKDRSSFELESENFMENGANIAEDDNHVHAQQSPLEPEAPGWSGFVDTTAAKEFTTQNQKSQDVGFWEGEVVRELSVEEQIKRNRYYDEDEDEE
uniprot
proteins
function
FUNCTION: Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity). Acts as a negative regulator of primary cilium formation (By similarity). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (PubMed:29880681). {ECO:0000250|UniProtKB:Q9UHB6, ECO:0000269|PubMed:29880681}.
uniprot
proteins
mass_dalton
84060
uniprot
proteins
mutagenesis
MUTAGEN 164..166; /note="CLG->AAA: Decreases interaction with NPC1L1."; /evidence="ECO:0000269|PubMed:29880681"; MUTAGEN 360; /note="S->A: Abolished phosphorylation by MAPK1/MAPK3."; /evidence="ECO:0000269|PubMed:17875928"; MUTAGEN 602; /note="S->A: Reduced phosphorylation by MAPK1/MAPK3."; /evidence="ECO:0000269|PubMed:17875928"; MUTAGEN 692; /note="S->A: Reduced phosphorylation by MAPK1/MAPK3."; /evidence="ECO:0000269|PubMed:17875928
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of the C-terminal region by MAPK1/MAPK3 reduces its association with F-actin and contributes to actin filament reorganization and enhances cell motility. {ECO:0000269|PubMed:17875928}.; PTM: Ubiquitinated by the ECS(RAB40B) complex leading to its degradation. {ECO:0000250|UniProtKB:Q9UHB6}.
uniprot
proteins
pubmed
11179679
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17875928
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
29880681
uniprot
proteins
sequence_length
753
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q9UHB6}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9UHB6}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:17875928}. Cell membrane {ECO:0000269|PubMed:29880681}. Cell projection, ruffle {ECO:0000269|PubMed:17875928}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9UHB6}. Note=Expressed mainly in the brush border membrane of the small intestine and colocalizes with NPC1L1 and MYO5B (PubMed:29880681). Colocalizes with PXN at focal adhesions in mesangial cells (By similarity). Colocalizes with actin stress fibers in quiescent cells. PDGF stimulation induced disassembly of stress fibers and formation of peripheral and dorsal ruffles, where LIMA1 is relocalized (PubMed:17875928). Localized at the lamellipodia, just behind lamellipodia actin ruffles (By similarity). {ECO:0000250|UniProtKB:Q9UHB6, ECO:0000269|PubMed:17875928, ECO:0000269|PubMed:29880681}.
uniprot
proteins