FMO1
entrez
2326
canonical
uniprot
Q01740
canonical
ensembl
ENSG00000010932
resolver
ensp
ENSP00000346901
resolver
ensp
ENSP00000356724
resolver
ensp
ENSP00000385543
resolver
ensp
ENSP00000481732
resolver
ensp
ENSP00000796978
resolver
genesymbol
FMO1
resolver
hgnc
HGNC:3769
resolver
uniprot
A8K248
resolver
uniprot
B2RCG5
resolver
uniprot
B7Z3P4
resolver
uniprot
Q5QPT2
resolver
uniprot
Q9UJC2
resolver
uniprot_entry
B2RCG5_HUMAN
resolver
uniprot_entry
FMO1_HUMAN
resolver
uniprot_sec
A8K248
resolver
uniprot_sec
B7Z3P4
resolver
uniprot_sec
Q5QPT2
resolver
uniprot_sec
Q9UJC2
resolver
amino_acid_sequence
MAKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEGRASLYKSVVSNSCKEMSCYSDFPFPEDYPNYVPNSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFPGINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQNMLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIRPSIKEVKENSVIFNNTSKEEPIDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPPPSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGKWEGARNAIMTQWDRTFKVIKARVVQESPSPFESFLKVFSFLALLVAIFLIFL
uniprot
proteins
ec_number
1.14.13.148
uniprot
proteins
ec_number
1.14.13.8
uniprot
proteins
function
FUNCTION: Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics (PubMed:32156684). Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes (PubMed:32156684). In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine (By similarity). {ECO:0000250|UniProtKB:P36365, ECO:0000269|PubMed:32156684}.
uniprot
proteins
mass_dalton
60311
uniprot
proteins
protein_family
FMO family
uniprot
proteins
pubmed
12527699
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1712018
uniprot
proteins
pubmed
32156684
uniprot
proteins
sequence_length
532
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P36365}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 511..531; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins