Hnrnpk
entrez
117282
canonical
uniprot
P61980
canonical
ensembl
ENSRNOG00000019113
resolver
ensp
ENSRNOP00000025915
resolver
ensp
ENSRNOP00000025980
resolver
enst
ENSRNOT00000025916
resolver
enst
ENSRNOT00000025980
resolver
genesymbol
Hnrnpk
resolver
genesymbol_syn
Hnrpk
resolver
genesymbol_syn
LOC100359916
resolver
genesymbol_syn
LOC100363335
resolver
uniprot
A0A8L2QEP8
resolver
uniprot
A0ACM8Q6U6
resolver
uniprot
F8WG62
resolver
uniprot
Q07244
resolver
uniprot
Q15671
resolver
uniprot
Q5D059
resolver
uniprot
Q60577
resolver
uniprot
Q922Y7
resolver
uniprot
Q96J62
resolver
uniprot_entry
A0A8L2QEP8_RAT
resolver
uniprot_entry
A0ACM8Q6U6_RAT
resolver
uniprot_entry
HNRPK_RAT
resolver
uniprot_entry
Q5D059_RAT
resolver
uniprot_sec
F8WG62
resolver
uniprot_sec
Q07244
resolver
uniprot_sec
Q15671
resolver
uniprot_sec
Q60577
resolver
uniprot_sec
Q922Y7
resolver
uniprot_sec
Q96J62
resolver
amino_acid_sequence
METEQPEETFPNTETNGEFGKRPAEDMEEEQAFKRSRNTDEMVELRILLQSKNAGAVIGKGGKNIKALRTDYNASVSVPDSSGPERILSISADIETIGEILKKIIPTLEEGLQLPSPTATSQLPLESDAVECLNYQHYKGSDFDCELRLLIHQSLAGGIIGVKGAKIKELRENTQTTIKLFQECCPHSTDRVVLIGGKPDRVVECIKIILDLISESPIKGRAQPYDPNFYDETYDYGGFTMMFDDRRGRPVGFPMRGRGGFDRMPPGRGGRPMPPSRRDYDDMSPRRGPPPPPPGRGGRGGSRARNLPLPPPPPPRGGDLMAYDRRGRPGDRYDGMVGFSADETWDSAIDTWSPSEWQMAYEPQGGSGYDYSYAGGRGSYGDLGGPIITTQVTIPKDLAGSIIGKGGQRIKQIRHESGASIKIDEPLEGSEDRIITITGTQDQIQNAQYLLQNSVKQYSGKFF
uniprot
proteins
function
FUNCTION: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity). {ECO:0000250|UniProtKB:P61978}.
uniprot
proteins
mass_dalton
50976
uniprot
proteins
post_translational_modification
PTM: Sumoylated by CBX4. Sumoylation is increased upon DNA damage, such as that produced by doxorubicin, etoposide, UV light and camptothecin, due to enhanced CBX4 phosphorylation by HIPK2 under these conditions (By similarity). {ECO:0000250|UniProtKB:P61978}.; PTM: Ubiquitinated by MDM2. Doxorubicin treatment does not affect monoubiquitination, but slightly decreases HNRNPK poly-ubiquitination (By similarity). {ECO:0000250|UniProtKB:P61978}.; PTM: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. {ECO:0000250|UniProtKB:P61978}.
uniprot
proteins
pubmed
19170760
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8127654
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P61978}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P61978}. Cell projection, podosome {ECO:0000250|UniProtKB:P61978}.
uniprot
proteins