PSMB9
entrez
5698
canonical
uniprot
P28065
canonical
ensembl
ENSG00000239836
resolver
ensembl
ENSG00000240065
resolver
ensembl
ENSG00000240118
resolver
ensembl
ENSG00000240508
resolver
ensembl
ENSG00000242711
resolver
ensembl
ENSG00000243067
resolver
ensembl
ENSG00000243594
resolver
ensembl
ENSG00000243958
resolver
ensp
ENSP00000363993
resolver
ensp
ENSP00000393744
resolver
ensp
ENSP00000407810
resolver
ensp
ENSP00000412027
resolver
enst
ENST00000427870
resolver
enst
ENST00000434471
resolver
enst
ENST00000453059
resolver
genesymbol
PSMB9
resolver
genesymbol_syn
LMP2
resolver
genesymbol_syn
PSMB6i
resolver
genesymbol_syn
RING12
resolver
hgnc
HGNC:9546
resolver
uniprot
B0V0T1
resolver
uniprot
Q16523
resolver
uniprot
Q5JNW4
resolver
uniprot_entry
PSB9_HUMAN
resolver
uniprot_sec
B0V0T1
resolver
uniprot_sec
Q16523
resolver
uniprot_sec
Q5JNW4
resolver
amino_acid_sequence
MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
uniprot
proteins
disease_involvement
DISEASE: Proteasome-associated autoinflammatory syndrome 3 (PRAAS3) [MIM:617591]: An autoinflammatory disorder characterized by onset in early infancy and recurrent fever, nodular dermatitis, myositis, panniculitis-induced lipodystrophy, lymphadenopathy, and immune dysregulation. Variable accompanying features may include joint contractures, hepatosplenomegaly, anemia, thrombocytopenia, recurrent infections, autoantibodies, and hypergammaglobulinemia. Some patients may have intracranial calcifications. PRAAS3 inheritance is autosomal recessive or digenic. {ECO:0000269|PubMed:26524591}. Note=The disease may be caused by variants affecting distinct genetic loci, including the gene represented in this entry.; DISEASE: Proteasome-associated autoinflammatory syndrome 6 (PRAAS6) [MIM:620796]: An autosomal dominant, autoinflammatory disorder characterized by recurrent fever, skin rash, myositis, liver dysfunction, splenomegaly, pulmonary hypertension, and basal ganglia calcifications. Disease onset is in early infancy. {ECO:0000269|PubMed:33727065, ECO:0000269|PubMed:34819510}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.25.1
uniprot
proteins
function
FUNCTION: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (PubMed:33727065, PubMed:34819510). The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. {ECO:0000269|PubMed:33727065, ECO:0000269|PubMed:34819510, ECO:0000269|PubMed:8163024}.
uniprot
proteins
mass_dalton
23264
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="G->A: Impairs correct processing at the consensus site."; /evidence="ECO:0000269|PubMed:9003765"; MUTAGEN 21; /note="T->A: Impairs correct processing at the consensus site."; /evidence="ECO:0000269|PubMed:9003765"; MUTAGEN 53; /note="K->A: Impairs correct processing at the consensus site."; /evidence="ECO:0000269|PubMed:9003765
uniprot
proteins
post_translational_modification
PTM: Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity. {ECO:0000250|UniProtKB:O35955}.
uniprot
proteins
protein_family
Peptidase T1B family
uniprot
proteins
pubmed
10924276
uniprot
proteins
pubmed
11493458
uniprot
proteins
pubmed
11717192
uniprot
proteins
pubmed
1429565
uniprot
proteins
pubmed
1453454
uniprot
proteins
pubmed
14550573
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15501285
uniprot
proteins
pubmed
15907481
uniprot
proteins
pubmed
16957778
uniprot
proteins
pubmed
17142736
uniprot
proteins
pubmed
17262812
uniprot
proteins
pubmed
18694960
uniprot
proteins
pubmed
1922385
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
26524591
uniprot
proteins
pubmed
26829627
uniprot
proteins
pubmed
33727065
uniprot
proteins
pubmed
34819510
uniprot
proteins
pubmed
7829535
uniprot
proteins
pubmed
8163024
uniprot
proteins
pubmed
8458375
uniprot
proteins
pubmed
8568858
uniprot
proteins
pubmed
8663318
uniprot
proteins
pubmed
9003765
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
uniprot
proteins