ABCB1
entrez
5243
canonical
uniprot
P08183
canonical
ensembl
ENSG00000085563
resolver
ensp
ENSP00000265724
resolver
ensp
ENSP00000478255
resolver
ensp
ENSP00000631152
resolver
genesymbol
ABCB1
resolver
genesymbol_syn
MDR1
resolver
genesymbol_syn
PGY1
resolver
hgnc
HGNC:40
resolver
uniprot
A4D1D2
resolver
uniprot
A8K294
resolver
uniprot
B5AK60
resolver
uniprot
Q12755
resolver
uniprot
Q14812
resolver
uniprot_entry
A4D1D2_HUMAN
resolver
uniprot_entry
MDR1_HUMAN
resolver
uniprot_sec
A8K294
resolver
uniprot_sec
B5AK60
resolver
uniprot_sec
Q12755
resolver
uniprot_sec
Q14812
resolver
activity_regulation
ACTIVITY REGULATION: Translocase activity is inhibited by verapamil and is sensitive to energy depletion (PubMed:35507548, PubMed:8898203). Inhibited by nicardipine (PubMed:35507548). Inhibited by PSC833 (PubMed:35507548). Inhibited by vanadate (PubMed:35507548). C1orf115 regulates drug efflux through modulation of ABCB1 localization and activity (PubMed:35970996). Not inhibited by amantadine (PubMed:35507548). {ECO:0000269|PubMed:35507548, ECO:0000269|PubMed:35970996, ECO:0000269|PubMed:8898203}.
uniprot
proteins
amino_acid_sequence
MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ
uniprot
proteins
disease_involvement
DISEASE: Inflammatory bowel disease 13 (IBD13) [MIM:612244]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Encephalopathy, acute transient (ENPAT) [MIM:620950]: An autosomal recessive neurologic disorder triggered by specific drugs, or acute febrile or afebrile illness. Clinical features include encephalopathy, ataxia, spasticity, pyramidal signs, diplopia, vomiting, and coma. Symptoms fully resolve within few days. {ECO:0000269|PubMed:32627353, ECO:0000269|PubMed:32813957}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
7.6.2.1
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
function
FUNCTION: Translocates phospholipids and drugs across the membrane (PubMed:2897240, PubMed:35970996, PubMed:8898203, PubMed:9038218, PubMed:35507548). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:35970996, PubMed:9038218). May contribute to hepatobiliary and renal excretion of etiocholanolone-3-glucuronate. Appears to have very low activity toward testosterone, androsterone and dihydrotestosterone glucuronates. {ECO:0000269|PubMed:2897240, ECO:0000269|PubMed:30959153, ECO:0000269|PubMed:35507548, ECO:0000269|PubMed:35970996, ECO:0000269|PubMed:8898203, ECO:0000269|PubMed:9038218}.
uniprot
proteins
mass_dalton
141479
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCB family
uniprot
proteins
protein_family
Multidrug resistance exporter (TC 3.A.1.201) subfamily
uniprot
proteins
pubmed
10716719
uniprot
proteins
pubmed
10790226
uniprot
proteins
pubmed
11240981
uniprot
proteins
pubmed
11258197
uniprot
proteins
pubmed
11829140
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14610718
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15488952
uniprot
proteins
pubmed
15618700
uniprot
proteins
pubmed
15618713
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
1967175
uniprot
proteins
pubmed
1972623
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24333728
uniprot
proteins
pubmed
2568832
uniprot
proteins
pubmed
28408210
uniprot
proteins
pubmed
2876781
uniprot
proteins
pubmed
2897240
uniprot
proteins
pubmed
30959153
uniprot
proteins
pubmed
32627353
uniprot
proteins
pubmed
32813957
uniprot
proteins
pubmed
35507548
uniprot
proteins
pubmed
35970996
uniprot
proteins
pubmed
8898203
uniprot
proteins
pubmed
9038218
uniprot
proteins
pubmed
9473242
uniprot
proteins
sequence_length
1280
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:35970996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Apical cell membrane {ECO:0000269|PubMed:28408210, ECO:0000269|PubMed:8898203}. Cytoplasm {ECO:0000269|PubMed:35970996}. Note=ABCB1 localization is influenced by C1orf115 expression levels (plasma membrane versus cytoplasm). Localized to the apical membrane of enterocytes (PubMed:28408210). {ECO:0000269|PubMed:28408210, ECO:0000269|PubMed:35970996}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..67; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 187..208; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 216..236; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 293..316; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 331..352; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 712..732; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 757..777; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 833..853; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 855..874; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 935..957; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 974..995; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins