Rab6a
entrez
84379
canonical
uniprot
Q9WVB1
canonical
ensembl
ENSRNOG00000018176
resolver
ensembl
ENSRNOG00055027994
resolver
ensembl
ENSRNOG00060002917
resolver
ensembl
ENSRNOG00065021494
resolver
ensp
ENSRNOP00000025104
resolver
ensp
ENSRNOP00000091495
resolver
ensp
ENSRNOP00000104096
resolver
ensp
ENSRNOP00055039879
resolver
ensp
ENSRNOP00060003398
resolver
ensp
ENSRNOP00065029449
resolver
enst
ENSRNOT00000025104
resolver
enst
ENSRNOT00000106849
resolver
enst
ENSRNOT00000164517
resolver
enst
ENSRNOT00055048513
resolver
enst
ENSRNOT00060004737
resolver
enst
ENSRNOT00065036568
resolver
genesymbol
Rab6a
resolver
genesymbol_syn
Rab6
resolver
uniprot
A0A8I6AFQ7
resolver
uniprot
A0ABK0LIA0
resolver
uniprot_entry
A0A8I6AFQ7_RAT
resolver
uniprot_entry
A0ABK0LIA0_RAT
resolver
uniprot_entry
RAB6A_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:P20340}.
uniprot
proteins
amino_acid_sequence
MSAGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVNEGGCSC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Recruits VPS13B to the Golgi membrane. Plays a role in neuron projection development. {ECO:0000250|UniProtKB:P20340}.
uniprot
proteins
mass_dalton
23590
uniprot
proteins
post_translational_modification
PTM: Prenylated. {ECO:0000250|UniProtKB:P20340}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11062069
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:P20340}; Lipid-anchor {ECO:0000250|UniProtKB:P20340}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:P35279}; Peripheral membrane protein {ECO:0000305}. Note=BICD2 facilitates its targeting to Golgi apparatus membrane.
uniprot
proteins