AGXT2
entrez
64902
canonical
uniprot
Q9BYV1
canonical
ensembl
ENSG00000113492
resolver
ensp
ENSP00000231420
resolver
ensp
ENSP00000422799
resolver
ensp
ENSP00000479154
resolver
ensp
ENSP00000523254
resolver
ensp
ENSP00000523255
resolver
genesymbol
AGXT2
resolver
genesymbol_syn
AGT2
resolver
hgnc
HGNC:14412
resolver
uniprot
B7ZM47
resolver
uniprot
E9PDL7
resolver
uniprot
Q53FB4
resolver
uniprot
Q53FY7
resolver
uniprot
Q53G03
resolver
uniprot
Q5W7Q1
resolver
uniprot_entry
AGT2_HUMAN
resolver
uniprot_sec
B7ZM47
resolver
uniprot_sec
E9PDL7
resolver
uniprot_sec
Q53FB4
resolver
uniprot_sec
Q53FY7
resolver
uniprot_sec
Q53G03
resolver
uniprot_sec
Q5W7Q1
resolver
amino_acid_sequence
MTLIWRHLLRPLCLVTSAPRILEMHPFLSLGTSRTSVTKLSLHTKPRMPPCDFMPERYQSLGYNRVLEIHKEHLSPVVTAYFQKPLLLHQGHMEWLFDAEGSRYLDFFSGIVTVSVGHCHPKVNAVAQKQLGRLWHTSTVFFHPPMHEYAEKLAALLPEPLKVIFLVNSGSEANELAMLMARAHSNNIDIISFRGAYHGCSPYTLGLTNVGTYKMELPGGTGCQPTMCPDVFRGPWGGSHCRDSPVQTIRKCSCAPDCCQAKDQYIEQFKDTLSTSVAKSIAGFFAEPIQGVNGVVQYPKGFLKEAFELVRARGGVCIADEVQTGFGRLGSHFWGFQTHDVLPDIVTMAKGIGNGFPMAAVITTPEIAKSLAKCLQHFNTFGGNPMACAIGSAVLEVIKEENLQENSQEVGTYMLLKFAKLRDEFEIVGDVRGKGLMIGIEMVQDKISCRPLPREEVNQIHEDCKHMGLLVGRGSIFSQTFRIAPSMCITKPEVDFAVEVFRSALTQHMERRAK
uniprot
proteins
ec_number
2.6.1.18
uniprot
proteins
ec_number
2.6.1.40
uniprot
proteins
ec_number
2.6.1.44
uniprot
proteins
function
FUNCTION: Multifunctional aminotransferase with a broad substrate specificity (PubMed:20018850, PubMed:23023372, PubMed:24586340). Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor (By similarity). Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine (PubMed:24586340). Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate (By similarity). Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA) (PubMed:20018850, PubMed:23023372). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (PubMed:20018850, PubMed:23023372). {ECO:0000250|UniProtKB:Q64565, ECO:0000269|PubMed:20018850, ECO:0000269|PubMed:23023372, ECO:0000269|PubMed:24586340}.
uniprot
proteins
mass_dalton
57156
uniprot
proteins
protein_family
Class-III pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20018850
uniprot
proteins
pubmed
23023372
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24586340
uniprot
proteins
pubmed
24834905
uniprot
proteins
pubmed
31818439
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20018850, ECO:0000269|PubMed:24586340, ECO:0000269|PubMed:31818439}.
uniprot
proteins