GPHB5
entrez
122876
canonical
uniprot
Q86YW7
canonical
ensembl
ENSG00000179600
resolver
ensp
ENSP00000478993
resolver
ensp
ENSP00000479431
resolver
enst
ENST00000314140
resolver
enst
ENST00000621500
resolver
genesymbol
GPHB5
resolver
genesymbol_syn
GPB5
resolver
genesymbol_syn
ZLUT1
resolver
hgnc
HGNC:18055
resolver
uniprot
Q6NTD0
resolver
uniprot
Q8NFW2
resolver
uniprot_entry
GPHB5_HUMAN
resolver
uniprot_sec
Q6NTD0
resolver
uniprot_sec
Q8NFW2
resolver
amino_acid_sequence
MKLAFLFLGPMALLLLAGYGCVLGASSGNLRTFVGCAVREFTFLAKKPGCRGLRITTDACWGRCETWEKPILEPPYIEAHHRVCTYNETKQVTVKLPNCAPGVDPFYTYPVAIRCDCGACSTATTECETI
uniprot
proteins
function
FUNCTION: Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. {ECO:0000269|PubMed:12045258, ECO:0000269|PubMed:16210345}.
uniprot
proteins
mass_dalton
14232
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:12045258}.
uniprot
proteins
protein_family
Glycoprotein hormones subunit beta family
uniprot
proteins
pubmed
12045258
uniprot
proteins
pubmed
12089349
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16210345
uniprot
proteins
sequence_length
130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins