Cabp4
entrez
73660
canonical
uniprot
Q8VHC5
canonical
ensembl
ENSMUSG00000024842
resolver
ensp
ENSMUSP00000025761
resolver
enst
ENSMUST00000025761
resolver
genesymbol
Cabp4
resolver
uniprot_entry
CABP4_MOUSE
resolver
amino_acid_sequence
MATEHNVQLVPGSQKIPKGVVSPRSAAEGPALTRRRSKKESWHPGSQKASSGDQSSSQGSEASGSSKHPPRTKVGQEEPSSAPARPASHRHSHRHRSDPQQDAAQRTYGPLLNRMFGKDRELGPEELEELQAAFEEFDTDQDGYIGYRELGDCMRTLGYMPTEMELLEVSQHVKMRMGGFVDFEEFVELISPKLREETAHMLGVRELRIAFREFDKDRDGRITVAELRQAAPALLGEPLEGTELDEMLREMDLNGDGTIDFDEFVMMLSTG
uniprot
proteins
function
FUNCTION: Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages. {ECO:0000269|PubMed:15452577, ECO:0000269|PubMed:16249514, ECO:0000269|PubMed:17050707, ECO:0000269|PubMed:17947313}.
uniprot
proteins
mass_dalton
30268
uniprot
proteins
mutagenesis
MUTAGEN 37; /note="S->A: Decreased phosphorylation."; /evidence="ECO:0000269|PubMed:18003854"; MUTAGEN 46; /note="S->A: No effect on phosphorylation."; /evidence="ECO:0000269|PubMed:18003854"; MUTAGEN 50..51; /note="SS->AA: No effect on phosphorylation."; /evidence="ECO:0000269|PubMed:18003854"; MUTAGEN 149; /note="E->Q: Loss of calcium binding; when associated with Q-226 and Q-263."; /evidence="ECO:0000269|PubMed:18003854"; MUTAGEN 223; /note="T->A: No effect on phosphorylation."; /evidence="ECO:0000269|PubMed:18003854"; MUTAGEN 226; /note="E->Q: Loss of calcium binding; when associated with Q-149 and Q-263."; /evidence="ECO:0000269|PubMed:18003854"; MUTAGEN 263; /note="E->Q: Loss of calcium binding; when associated with Q-149 and Q-226."; /evidence="ECO:0000269|PubMed:18003854
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity, but has no effect on calcium binding. {ECO:0000269|PubMed:18003854}.
uniprot
proteins
pubmed
15452577
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16249514
uniprot
proteins
pubmed
17050707
uniprot
proteins
pubmed
17947313
uniprot
proteins
pubmed
18003854
uniprot
proteins
pubmed
18296658
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P57796}. Presynapse {ECO:0000269|PubMed:15452577}. Note=Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors. {ECO:0000269|PubMed:15452577}.
uniprot
proteins