Dnaja1
entrez
15502
canonical
uniprot
P63037
canonical
ensembl
ENSMUSG00000028410
resolver
ensp
ENSMUSP00000030118
resolver
ensp
ENSMUSP00000129730
resolver
ensp
ENSMUSP00000280105
resolver
enst
ENSMUST00000030118
resolver
enst
ENSMUST00000164233
resolver
genesymbol
Dnaja1
resolver
genesymbol_syn
Dnaj2
resolver
genesymbol_syn
Hsj2
resolver
genesymbol_syn
Hspf4
resolver
uniprot
P54102
resolver
uniprot
Q5NTY0
resolver
uniprot_entry
DNJA1_MOUSE
resolver
uniprot_entry
Q5NTY0_MOUSE
resolver
uniprot_sec
P54102
resolver
amino_acid_sequence
MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLADSKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS
uniprot
proteins
function
FUNCTION: Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. {ECO:0000250, ECO:0000269|PubMed:14752510}.
uniprot
proteins
mass_dalton
44868
uniprot
proteins
pubmed
14752510
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9799614
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cytoplasm {ECO:0000250}. Microsome {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Primarily cytoplasmic and associated with microsomes. A minor proportion is associated with nuclei and mitochondria (By similarity). {ECO:0000250}.
uniprot
proteins