Creb1
entrez
12912
canonical
uniprot
Q01147
canonical
ensembl
ENSMUSG00000025958
resolver
ensp
ENSMUSP00000059973
resolver
ensp
ENSMUSP00000084624
resolver
ensp
ENSMUSP00000132860
resolver
ensp
ENSMUSP00000139995
resolver
ensp
ENSMUSP00000140112
resolver
ensp
ENSMUSP00000234438
resolver
ensp
ENSMUSP00000234442
resolver
enst
ENSMUST00000171164
resolver
genesymbol
Creb1
resolver
genesymbol_syn
Creb-1
resolver
uniprot
F6VJE9
resolver
uniprot
Q543W0
resolver
uniprot
Q547S9
resolver
uniprot
Q62347
resolver
uniprot_entry
CREB1_MOUSE
resolver
uniprot_entry
F6VJE9_MOUSE
resolver
uniprot_entry
Q543W0_MOUSE
resolver
uniprot_entry
Q547S9_MOUSE
resolver
uniprot_entry
Q62347_MOUSE
resolver
amino_acid_sequence
MTMESGADNQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
uniprot
proteins
function
FUNCTION: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (By similarity). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (PubMed:11970866, PubMed:21728997). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (PubMed:30566056). {ECO:0000250|UniProtKB:P16220, ECO:0000250|UniProtKB:P27925, ECO:0000269|PubMed:11970866, ECO:0000269|PubMed:21728997, ECO:0000269|PubMed:30566056}.
uniprot
proteins
mass_dalton
35122
uniprot
proteins
mutagenesis
MUTAGEN 119; /note="S->A: Loss of phosphorylation by RPS6KA4 and RPS6KA5."; /evidence="ECO:0000269|PubMed:18690222"; MUTAGEN 123..124; /note="IL->AA: Abolishes CREBBP binding."; /evidence="ECO:0000269|PubMed:8552098"; MUTAGEN 128; /note="S->A: Attenuates light-induced phase shifts of locomotion and expression of c-Fos and mPer1 in the SCN."; /evidence="ECO:0000269|PubMed:11970866
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-119 allows CREBBP binding. Stimulated by phosphorylation. Phosphorylated Ser-128 can be detected in the suprachiasmatic nucleus (SCN), the amygdala, the cortex, and the hippocampus but not in the striatum nor in the cerebellum. In the SCN, phosphorylation of Ser-128 and Ser-119 are stimulated by light exposure and submitted to circadian oscillations. In the retina, only phosphorylation of Ser-119 can be detected upon light exposure. Phosphorylation of both Ser-119 and Ser-128 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-119. CaMK4 is much more potent than CAMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-128. Phosphorylation of Ser-128 blocks CREB-mediated transcription even when Ser-119 is phosphorylated. Phosphorylated by CaMK1. Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP (By similarity). Phosphorylated at Ser-119 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. CREBL2 positively regulates phosphorylation at Ser-119 thereby stimulating CREB1 transcriptional activity. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion. Phosphorylated by TSSK4 on Ser-119 (By similarity). {ECO:0000250|UniProtKB:P16220, ECO:0000269|PubMed:11970866, ECO:0000269|PubMed:18690222, ECO:0000269|PubMed:20852621, ECO:0000269|PubMed:8552098}.; PTM: Sumoylated with SUMO1. Sumoylation on Lys-290, but not on Lys-271, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
10952992
uniprot
proteins
pubmed
11970866
uniprot
proteins
pubmed
1387109
uniprot
proteins
pubmed
1532935
uniprot
proteins
pubmed
18690222
uniprot
proteins
pubmed
20852621
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21728997
uniprot
proteins
pubmed
30566056
uniprot
proteins
pubmed
34914893
uniprot
proteins
pubmed
8552098
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00312, ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:21728997}.
uniprot
proteins