Kcnj5
entrez
29713
canonical
uniprot
P48548
canonical
ensembl
ENSRNOG00000033796
resolver
ensembl
ENSRNOG00055008907
resolver
ensembl
ENSRNOG00060011773
resolver
ensp
ENSRNOP00000048134
resolver
ensp
ENSRNOP00000079101
resolver
ensp
ENSRNOP00000099016
resolver
ensp
ENSRNOP00055012003
resolver
ensp
ENSRNOP00060015645
resolver
enst
ENSRNOT00000041038
resolver
enst
ENSRNOT00000110676
resolver
enst
ENSRNOT00000159264
resolver
enst
ENSRNOT00055015036
resolver
enst
ENSRNOT00060019915
resolver
genesymbol
Kcnj5
resolver
genesymbol_syn
Girk4
resolver
uniprot
A0A8I6G4T8
resolver
uniprot
A0ABK0KWV4
resolver
uniprot_entry
A0A8I6G4T8_RAT
resolver
uniprot_entry
A0ABK0KWV4_RAT
resolver
uniprot_entry
KCNJ5_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Heteromultimer composed of KCNJ3/GIRK1 and KCNJ5/GIRK4 is activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2). {ECO:0000269|PubMed:9486652}.
uniprot
proteins
amino_acid_sequence
MAGDSRNAMNQDMEIGVTSQDHKKIPKQARDYIPIATDRTRLLPEGKKPRQRYMEKTGKCNVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTITWLFFGFIWWLIAYVRGDLDHVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINEKSPFWEMSRAQLEQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEMKRNGQLLQSLPSPPLLGGCAEAEKEAEAEHDEEEEPNGLSVSRATRGSM
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. This potassium channel is controlled by G proteins. {ECO:0000269|PubMed:7592809, ECO:0000269|PubMed:7877685, ECO:0000269|PubMed:9486652}.
uniprot
proteins
mass_dalton
47783
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ5 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7592809
uniprot
proteins
pubmed
7877685
uniprot
proteins
pubmed
8047164
uniprot
proteins
pubmed
8524415
uniprot
proteins
pubmed
8834003
uniprot
proteins
pubmed
9486652
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:7877685}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 87..111; /note="Helical; Name=M1"; /evidence="ECO:0000250"; TRANSMEM 164..185; /note="Helical; Name=M2"; /evidence="ECO:0000250
uniprot
proteins