Smim20
entrez
501923
canonical
uniprot
C0HLM6
canonical
genesymbol
Smim20
resolver
uniprot_entry
SIM20_RAT
resolver
amino_acid_sequence
MAAARNLRTALIFGGFISMVGAAFYPIYFRPLLRLEEYQKEQAVNRAGIVQEDVQPPGLKVWSDPFGRK
uniprot
proteins
function
FUNCTION: [Small integral membrane protein 20]: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (By similarity). Promotes the progression of complex assembly after the association of Mt-Co1/Cox11 with Cox4I1 and Cox6c (By similarity). Chaperone-like assembly factor required to stabilize newly synthesized Mt-Co1/Cox1 and to prevent its premature turnover (By similarity). {ECO:0000250|UniProtKB:Q8N5G0}.; FUNCTION: [Phoenixin-14]: Peptide involved in a broad spectrum of regulatory functions (PubMed:27440717, PubMed:28844870, PubMed:28965207, PubMed:29364701, PubMed:30609107). Is a ligand for GPR173 (PubMed:27440717). As part of the reproductive cycle, it regulates gonadotropin-releasing hormone (GnRH) signaling in the hypothalamus and pituitary gland which augments the release of luteinizing hormone (PubMed:22963497, PubMed:27440717). More specifically, it regulates the expression of transcription factors CEBPB and POU2F1/OCT1 through the cAMP-PKA signaling pathway, which subsequently regulate the expression of GNRHR and KISS1 (By similarity). Plays a protective role in memory retention through activation of GNRHR (By similarity). Regulates the secretion of AVP by hypothalamic neurons (PubMed:29364701). Plays a role in the transduction of the itch sensation (By similarity). Induces anxiolytic effects, reducing behavior associated with anxiety (By similarity). Regulates food intake as well as satiation and satiety by increasing NUCB2 expression in neurons (PubMed:28844870, PubMed:30930149). In the ovary, it regulates follicular growth by stimulating granulosa cell proliferation by increasing the expression of GPR173, CREB1, CYP19A1, KITLG, FSHR, and LHCGR (By similarity). It also increases the production of estradiol (E2) (By similarity). In the heart, it regulates contractility and relaxation by activating the AKT1-NOS3 and MAPK1-MAPK3 signaling pathways (PubMed:28965207). It also plays a cardioprotective role during ischemia, where it activates the SAFE and RISK pathways (PubMed:28965207). Stimulates the proliferation and differentiation of preadipocytes (PubMed:30251651). In pancreatic islet cells, it induces proliferation of islet cells as well as the production of INS1 and INS2 through activation of the MAPK1-MAPK3 signaling pathways (PubMed:31422055). {ECO:0000250|UniProtKB:D3Z7Q2, ECO:0000250|UniProtKB:Q8N5G0, ECO:0000269|PubMed:22963497, ECO:0000269|PubMed:27440717, ECO:0000269|PubMed:28844870, ECO:0000269|PubMed:28965207, ECO:0000269|PubMed:29364701, ECO:0000269|PubMed:30251651, ECO:0000269|PubMed:30609107, ECO:0000269|PubMed:30930149, ECO:0000269|PubMed:31422055}.; FUNCTION: [Phoenixin-20]: Peptide involved in a broad spectrum of regulatory functions (PubMed:27440717, PubMed:28844870, PubMed:28965207, PubMed:29364701, PubMed:30609107). Is a ligand for GPR173 (PubMed:27440717). As part of the reproductive cycle, it regulates gonadotropin-releasing hormone (GnRH) signaling in the hypothalamus and pituitary gland which augments the release of luteinizing hormone (PubMed:22963497, PubMed:27440717). More specifically, it regulates the expression of transcription factors CEBPB and POU2F1/OCT1 through the cAMP-PKA signaling pathway, which subsequently regulate the expression of GNRHR and KISS1 (By similarity). Plays a protective role in memory retention through activation of GNRHR (By similarity). Regulates the secretion of AVP by hypothalamic neurons (PubMed:29364701). Plays a role in the transduction of the itch sensation (By similarity). Induces anxiolytic effects, reducing behavior associated with anxiety (By similarity). Regulates food intake as well as satiation and satiety by increasing NUCB2 expression in neurons (PubMed:28844870, PubMed:30930149). In the ovary, it regulates follicular growth by stimulating granulosa cell proliferation by increasing the expression of GPR173, CREB1, CYP19A1, KITLG, FSHR, and LHCGR (By similarity). It also increases the production of estradiol (E2) (By similarity). In the heart, it regulates contractility and relaxation by activating the AKT1-NOS3 and MAPK1-MAPK3 signaling pathways (PubMed:28965207). It also plays a cardioprotective role during ischemia, where it activates the SAFE and RISK pathways (PubMed:28965207). Stimulates the proliferation and differentiation of preadipocytes (PubMed:30251651). In pancreatic islet cells, it induces proliferation of islet cells as well as the production of INS1 and INS2 through activation of the MAPK1-MAPK3 signaling pathways (PubMed:31422055). {ECO:0000250|UniProtKB:D3Z7Q2, ECO:0000250|UniProtKB:Q8N5G0, ECO:0000269|PubMed:22963497, ECO:0000269|PubMed:27440717, ECO:0000269|PubMed:28844870, ECO:0000269|PubMed:28965207, ECO:0000269|PubMed:29364701, ECO:0000269|PubMed:30251651, ECO:0000269|PubMed:30609107, ECO:0000269|PubMed:30930149, ECO:0000269|PubMed:31422055}.
uniprot
proteins
mass_dalton
7800
uniprot
proteins
pubmed
22963497
uniprot
proteins
pubmed
23912037
uniprot
proteins
pubmed
27440717
uniprot
proteins
pubmed
28844870
uniprot
proteins
pubmed
28965207
uniprot
proteins
pubmed
29364701
uniprot
proteins
pubmed
30251651
uniprot
proteins
pubmed
30609107
uniprot
proteins
pubmed
30930149
uniprot
proteins
pubmed
31422055
uniprot
proteins
sequence_length
69
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Small integral membrane protein 20]: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8N5G0}; Single-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Phoenixin-14]: Secreted {ECO:0000269|PubMed:22963497, ECO:0000269|PubMed:30251651, ECO:0000269|PubMed:30609107, ECO:0000269|PubMed:31422055}.; SUBCELLULAR LOCATION: [Phoenixin-20]: Secreted {ECO:0000269|PubMed:22963497, ECO:0000269|PubMed:30251651, ECO:0000269|PubMed:30609107, ECO:0000269|PubMed:31422055}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins