TUB
entrez
7275
canonical
uniprot
P50607
canonical
ensembl
ENSG00000166402
resolver
ensp
ENSP00000299506
resolver
ensp
ENSP00000305426
resolver
ensp
ENSP00000434400
resolver
ensp
ENSP00000589607
resolver
ensp
ENSP00000796500
resolver
enst
ENST00000534099
resolver
genesymbol
TUB
resolver
hgnc
HGNC:12406
resolver
uniprot
D3DQU4
resolver
uniprot
E9PQR4
resolver
uniprot
O00293
resolver
uniprot
Q6B007
resolver
uniprot_entry
E9PQR4_HUMAN
resolver
uniprot_entry
TUB_HUMAN
resolver
uniprot_sec
D3DQU4
resolver
uniprot_sec
O00293
resolver
uniprot_sec
Q6B007
resolver
amino_acid_sequence
MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE
uniprot
proteins
disease_involvement
DISEASE: Retinal dystrophy and obesity (RDOB) [MIM:616188]: A disease characterized by obesity, night blindness, decreased visual acuity, and electrophysiological features of a rod cone dystrophy. {ECO:0000269|PubMed:24375934}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. {ECO:0000250, ECO:0000269|PubMed:19837063}.
uniprot
proteins
mass_dalton
55651
uniprot
proteins
protein_family
TUB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19837063
uniprot
proteins
pubmed
24375934
uniprot
proteins
pubmed
8612280
uniprot
proteins
pubmed
9096357
uniprot
proteins
sequence_length
506
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). {ECO:0000250}.
uniprot
proteins