PSMD14
entrez
10213
canonical
uniprot
O00487
canonical
ensembl
ENSG00000115233
resolver
ensp
ENSP00000386541
resolver
ensp
ENSP00000569728
resolver
ensp
ENSP00000569729
resolver
ensp
ENSP00000569731
resolver
ensp
ENSP00000585250
resolver
ensp
ENSP00000585251
resolver
ensp
ENSP00000585257
resolver
ensp
ENSP00000631599
resolver
ensp
ENSP00000631604
resolver
ensp
ENSP00000631605
resolver
enst
ENST00000409682
resolver
enst
ENST00000899669
resolver
enst
ENST00000899670
resolver
enst
ENST00000899672
resolver
enst
ENST00000915191
resolver
enst
ENST00000915192
resolver
enst
ENST00000915198
resolver
enst
ENST00000961540
resolver
enst
ENST00000961545
resolver
enst
ENST00000961546
resolver
genesymbol
PSMD14
resolver
genesymbol_syn
POH1
resolver
hgnc
HGNC:16889
resolver
uniprot
A0A140VKF2
resolver
uniprot
B3KNW2
resolver
uniprot
O00176
resolver
uniprot_entry
A0A140VKF2_HUMAN
resolver
uniprot_entry
PSDE_HUMAN
resolver
uniprot_sec
B3KNW2
resolver
uniprot_sec
O00176
resolver
amino_acid_sequence
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
uniprot
proteins
ec_number
3.4.19.12
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:9374539, PubMed:1317798). The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex (PubMed:22909820). Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation (PubMed:22909820). Also involved in homologous recombination repair by promoting RAD51 loading (PubMed:22909820). Regulates macroautophagy by ensuring Golgi-to-ER retrograde transport through its deubiquitinating activity on K63-linked ubiquitin chains. This activity prevents the retention of essential autophagy proteins at the Golgi, enabling their trafficking to autophagosome formation sites and supporting Golgi-ER membrane recycling critical for effective autophagy (PubMed:32210007). {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:22909820, ECO:0000269|PubMed:32210007, ECO:0000269|PubMed:9374539}.
uniprot
proteins
mass_dalton
34577
uniprot
proteins
mutagenesis
MUTAGEN 113..115; /note="HSH->ASA: Abolishes ubiquitin thioesterase activity, leading to prevent maintenance of JMJD2A/KDM4A on chromatin."; /evidence="ECO:0000269|PubMed:22909820
uniprot
proteins
protein_family
PSMD14 subfamily
uniprot
proteins
protein_family
Peptidase M67A family
uniprot
proteins
pubmed
1317798
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
17693683
uniprot
proteins
pubmed
19214193
uniprot
proteins
pubmed
19349277
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22909820
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
32210007
uniprot
proteins
pubmed
9374539
uniprot
proteins
sequence_length
310
uniprot
proteins