LPP
entrez
4026
canonical
uniprot
Q93052
canonical
ensembl
ENSG00000145012
resolver
ensp
ENSP00000392667
resolver
ensp
ENSP00000393602
resolver
ensp
ENSP00000405138
resolver
ensp
ENSP00000478901
resolver
ensp
ENSP00000482617
resolver
ensp
ENSP00000524545
resolver
ensp
ENSP00000524547
resolver
ensp
ENSP00000524548
resolver
ensp
ENSP00000524549
resolver
ensp
ENSP00000524550
resolver
ensp
ENSP00000524551
resolver
ensp
ENSP00000524552
resolver
ensp
ENSP00000524553
resolver
ensp
ENSP00000524554
resolver
ensp
ENSP00000524555
resolver
ensp
ENSP00000524557
resolver
ensp
ENSP00000524558
resolver
ensp
ENSP00000524559
resolver
ensp
ENSP00000524561
resolver
ensp
ENSP00000524562
resolver
ensp
ENSP00000524564
resolver
ensp
ENSP00000524565
resolver
ensp
ENSP00000524567
resolver
ensp
ENSP00000524568
resolver
ensp
ENSP00000524569
resolver
ensp
ENSP00000524570
resolver
ensp
ENSP00000524571
resolver
ensp
ENSP00000524573
resolver
ensp
ENSP00000524574
resolver
ensp
ENSP00000524576
resolver
ensp
ENSP00000524577
resolver
ensp
ENSP00000524579
resolver
ensp
ENSP00000524580
resolver
ensp
ENSP00000524581
resolver
ensp
ENSP00000524582
resolver
ensp
ENSP00000524583
resolver
ensp
ENSP00000524584
resolver
ensp
ENSP00000524585
resolver
ensp
ENSP00000524587
resolver
ensp
ENSP00000524588
resolver
ensp
ENSP00000524589
resolver
ensp
ENSP00000524590
resolver
ensp
ENSP00000524591
resolver
ensp
ENSP00000524593
resolver
ensp
ENSP00000619787
resolver
ensp
ENSP00000619788
resolver
ensp
ENSP00000619789
resolver
ensp
ENSP00000619791
resolver
ensp
ENSP00000619794
resolver
ensp
ENSP00000619796
resolver
ensp
ENSP00000619797
resolver
ensp
ENSP00000619798
resolver
ensp
ENSP00000619799
resolver
ensp
ENSP00000619800
resolver
ensp
ENSP00000619802
resolver
ensp
ENSP00000619804
resolver
ensp
ENSP00000619805
resolver
ensp
ENSP00000619806
resolver
ensp
ENSP00000619807
resolver
ensp
ENSP00000776186
resolver
ensp
ENSP00000776190
resolver
enst
ENST00000414139
resolver
enst
ENST00000420410
resolver
enst
ENST00000617246
resolver
enst
ENST00000618621
resolver
enst
ENST00000854486
resolver
enst
ENST00000854488
resolver
enst
ENST00000854489
resolver
enst
ENST00000854490
resolver
enst
ENST00000854491
resolver
enst
ENST00000854492
resolver
enst
ENST00000854493
resolver
enst
ENST00000854494
resolver
enst
ENST00000854495
resolver
enst
ENST00000854496
resolver
enst
ENST00000854498
resolver
enst
ENST00000854499
resolver
enst
ENST00000854500
resolver
enst
ENST00000854502
resolver
enst
ENST00000854503
resolver
enst
ENST00000854505
resolver
enst
ENST00000854508
resolver
enst
ENST00000854509
resolver
enst
ENST00000854510
resolver
enst
ENST00000854511
resolver
enst
ENST00000854512
resolver
enst
ENST00000854514
resolver
enst
ENST00000854515
resolver
enst
ENST00000854517
resolver
enst
ENST00000854518
resolver
enst
ENST00000854520
resolver
enst
ENST00000854521
resolver
enst
ENST00000854522
resolver
enst
ENST00000854523
resolver
enst
ENST00000854524
resolver
enst
ENST00000854525
resolver
enst
ENST00000854526
resolver
enst
ENST00000854528
resolver
enst
ENST00000854529
resolver
enst
ENST00000854530
resolver
enst
ENST00000854531
resolver
enst
ENST00000854532
resolver
enst
ENST00000854534
resolver
enst
ENST00000949728
resolver
enst
ENST00000949729
resolver
enst
ENST00000949730
resolver
enst
ENST00000949732
resolver
enst
ENST00000949735
resolver
enst
ENST00000949737
resolver
enst
ENST00000949738
resolver
enst
ENST00000949739
resolver
enst
ENST00000949740
resolver
enst
ENST00000949741
resolver
enst
ENST00000949743
resolver
enst
ENST00000949745
resolver
enst
ENST00000949746
resolver
enst
ENST00000949747
resolver
enst
ENST00000949748
resolver
genesymbol
LPP
resolver
hgnc
HGNC:6679
resolver
uniprot
A1L4L6
resolver
uniprot
B7Z871
resolver
uniprot
B7Z8W0
resolver
uniprot
B7ZLW0
resolver
uniprot
D3DNV6
resolver
uniprot
Q8NFX5
resolver
uniprot_entry
B7Z871_HUMAN
resolver
uniprot_entry
B7Z8W0_HUMAN
resolver
uniprot_entry
B7ZLW0_HUMAN
resolver
uniprot_entry
LPP_HUMAN
resolver
uniprot_sec
A1L4L6
resolver
uniprot_sec
D3DNV6
resolver
uniprot_sec
Q8NFX5
resolver
amino_acid_sequence
MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving LPP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with HMGA2 is shown in lipomas.; DISEASE: Note=A chromosomal aberration involving LPP is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with HMGA2 is detected in pulmonary chondroid hamartomas.; DISEASE: Note=A chromosomal aberration involving LPP is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with HMGA2 is also shown in one parosteal lipoma.; DISEASE: Note=A chromosomal aberration involving LPP is associated with acute monoblastic leukemia. Translocation t(3;11)(q28;q23) with KMT2A/MLL1 is associated with acute monoblastic leukemia.
uniprot
proteins
function
FUNCTION: May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}.
uniprot
proteins
mass_dalton
65746
uniprot
proteins
mutagenesis
MUTAGEN 610; /note="T->A: Abolishes binding to SCRIB."; /evidence="ECO:0000269|PubMed:15649318"; MUTAGEN 612; /note="L->A: Abolishes binding to SCRIB."; /evidence="ECO:0000269|PubMed:15649318
uniprot
proteins
protein_family
Zyxin/ajuba family
uniprot
proteins
pubmed
10637295
uniprot
proteins
pubmed
11066083
uniprot
proteins
pubmed
11433529
uniprot
proteins
pubmed
12063392
uniprot
proteins
pubmed
12441356
uniprot
proteins
pubmed
12522270
uniprot
proteins
pubmed
12615977
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15649318
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
8812423
uniprot
proteins
pubmed
9772904
uniprot
proteins
sequence_length
612
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cell junction. Cell membrane. Note=Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and KMT2A/MLL1.
uniprot
proteins