Hscb
entrez
100900
canonical
uniprot
Q8K3A0
canonical
ensembl
ENSMUSG00000043510
resolver
ensp
ENSMUSP00000062811
resolver
ensp
ENSMUSP00000290302
resolver
ensp
ENSMUSP00000354064
resolver
enst
ENSMUST00000056937
resolver
genesymbol
Hscb
resolver
genesymbol_syn
Hsc20
resolver
uniprot
A0A0R4J0T0
resolver
uniprot
Q3V294
resolver
uniprot_entry
A0A0R4J0T0_MOUSE
resolver
uniprot_entry
HSC20_MOUSE
resolver
uniprot_sec
Q3V294
resolver
amino_acid_sequence
MWGCGARALLGVWEVRLAGFLGRRLLGSNAAAGKSIAPQCWNCGHAREAGCGDEFFCSHCRALQPPDPTRDYFSLMNCNRSFRVDVTKLQHRYQQLQRLVHPDFFSQKSQTEKHFSDKHSTLVNDAYKTLQAPLTRGLYLLKLQGIEIPEGTDYKADSQFLVEIMEINERLADAQSEAAMEEIEATVRAKQKEFTDNINSAFEQGDFEKAKELLTKMRYFSNIEEKIKLSKTPL
uniprot
proteins
function
FUNCTION: [Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]: Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria. Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain. Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 (By similarity). Plays an essential role in hematopoiesis (PubMed:32634119). {ECO:0000250|UniProtKB:Q8IWL3, ECO:0000269|PubMed:32634119}.; FUNCTION: [Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic]: Acts as a co-chaperone in iron-sulfur cluster assembly in the cytoplasm. Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1. This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT. {ECO:0000250|UniProtKB:Q8IWL3}.
uniprot
proteins
mass_dalton
26645
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; iron-sulfur cluster biosynthesis.
uniprot
proteins
protein_family
HscB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32634119
uniprot
proteins
sequence_length
234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic]: Cytoplasm {ECO:0000250|UniProtKB:Q8IWL3}.; SUBCELLULAR LOCATION: [Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]: Mitochondrion {ECO:0000250|UniProtKB:Q8IWL3}.
uniprot
proteins