Kcnu1
entrez
680912
canonical
uniprot
D4A6Z8
canonical
ensembl
ENSRNOG00000014741
resolver
ensembl
ENSRNOG00055007681
resolver
ensembl
ENSRNOG00060012318
resolver
ensp
ENSRNOP00000019935
resolver
ensp
ENSRNOP00055010237
resolver
ensp
ENSRNOP00060016463
resolver
enst
ENSRNOT00000019935
resolver
enst
ENSRNOT00055012845
resolver
enst
ENSRNOT00060020886
resolver
genesymbol
Kcnu1
resolver
genesymbol_syn
Kcnma3
resolver
genesymbol_syn
Ksper
resolver
genesymbol_syn
Slo3
resolver
uniprot_entry
KCNU1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by changes in cytosolic pH; activated by alkalization. Not activated by intracellular Ca(2+) (PubMed:32335912). VU0546110 acts as a selective inhibitor (By similarity). The auxiliary subunit LRRC52 shifts the activation of KCNU1 to more negative potentials at a given pH (PubMed:32335912). {ECO:0000250|UniProtKB:A8MYU2, ECO:0000269|PubMed:32335912}.
uniprot
proteins
amino_acid_sequence
MSQTLLDNLNKKELTETSCTIEIQAAFILSSLATFFGGLIVLFIFRIALKISRNWKTVKGPRGILELFSSRRIEVNPLRKLYFHGVFRERIEMLLSAQTIVGQVLVILVFVLSIGSLVIYFINSMDPVRKCSSYEDKIVHVDLSFNAFFSFYFGLRFWAAEDKIKFWLEMNSIVDIFTIPPTFISYYLKSNWLGLRFLRALRLLELPKILQILQVIKTSNSVKLSKLMSIVISTWFTAAGFLHLVENSGDPWLNGRNSQTMSYFESIYLVTATMSTVGFGDVVAKTSLGRIFIVFFTLGSLILFANYIPEMVELFSTRKKYNKPYEAVKGKKFIVVCGNITIDSVTAFLRNFLHRKAGEINIEIVFLGEAPPSVELETLLKCHTSCTTFVCGTALKFEDLKRVAVENAEACLILANPFCSDLHDEDNSNIMRVLSIKNYYPQTRVIIQMLQSQNKVFLSRIPNWNWSAGDNIICFAELKLGFIAQGCLVPGLCTFLTTLFIEQNQKVFPKHPWQKHFLNGLKNKILTQRLSNDFVGMTFPQVSRLCFLKMHLMLIAIQHKPLFHNCCSLILNPSSQVRLNKDTLGFFIAESSKDVKRALFYCSNCHSDVCNPELIGKCGCKNRSRQQLVAPTIMVMQSSLNEFAPTAEIYTSISREQTSSVTILTTRNMPVDTADDSDMLDSSGMFHWCRSMPLDKVVLKRSDKATHEFQNHIVACVFGDAHSSLMGLRNFVMPLRASNYTRQELKDIVFIGSLEYFQREWRFLRNFPKIHIMPGSALYTGDLHAVNVEQCSMCVILATPYKALSSQLLVDTETIMATLNIQALRISCPMSGSSKKEVNTSPTFSKYEGKQRYQQIPILTELKNPSNIHFIEQMDGLDEAIKGTSLHLSTAFSTGTVFSGTFLDSLLATAFYNYHVLELLQMLVTGGINSQTEHCLVKEKLYEGNEGGATFLSGRTRCKLGLLSLDETILSDIKPKKTFGQLFCGSLDNLGILCVGLYRMMDEGEHNSERKRFVITRPANECHLLPSDLVFCAIPFSITCDKSESNASIQDQDTTTNVTSMSQGSNFQGAQSALNEHSLSPASAMGEKKSPQLLNSRVYPLNLFDASDIDPGK
uniprot
proteins
function
FUNCTION: Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+) (PubMed:32335912). Represents the primary spermatozoan K(+) current. The channel underlies a pH-triggered membrane hyperpolarization during the process of sperm capacitation, as sperm encounter the alkaline environment near the ovum in the female reproductive tract, thereby playing an essential for male fertility (By similarity). {ECO:0000250|UniProtKB:A8MYU2, ECO:0000269|PubMed:32335912}.
uniprot
proteins
mass_dalton
125344
uniprot
proteins
protein_family
Calcium-activated (TC 1.A.1.3) subfamily
uniprot
proteins
protein_family
KCa1.1/KCNMA1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
32335912
uniprot
proteins
sequence_length
1113
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O54982}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:A8MYU2}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical; Name=Segment S0"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 138..158; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 166..186; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 227..247; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 291..311; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins