Pmm1
entrez
29858
canonical
uniprot
O35621
canonical
ensembl
ENSMUSG00000022474
resolver
ensp
ENSMUSP00000023112
resolver
ensp
ENSMUSP00000071405
resolver
enst
ENSMUST00000023112
resolver
enst
ENSMUST00000071462
resolver
genesymbol
Pmm1
resolver
uniprot
F6VI94
resolver
uniprot
Q545Q8
resolver
uniprot
Q91W01
resolver
uniprot_entry
F6VI94_MOUSE
resolver
uniprot_entry
PMM1_MOUSE
resolver
uniprot_entry
Q545Q8_MOUSE
resolver
uniprot_entry
Q91W01_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: IMP, a metabolite whose concentration is elevated in anoxia, inhibits phosphomannomutase and phosphoglucomutase activities and strongly enhances glucose-1,6-bisphosphatase activity. {ECO:0000269|PubMed:18927083}.
uniprot
proteins
amino_acid_sequence
MAVAVEGARRKERILCLFDVDGTLTPARQKIDPEVSAFLQKLRSRVQIGVVGGSDYSKIAEQLGEGDEVIEKFDYVFAENGTVQYKHGRLLSKQTIQNHLGEELLQDLINFCLSYMALLRLPKKRGTFIEFRNGMLNVSPIGRSCTLEERIEFSELDKKEKIREKFVEALKTEFAGKGLRFSRGGMISFDVFPEGWDKRYCLDSLDEDSFDIIHFFGNETSPGGNDFEIYADPRTVGHSVVSPQDTVQRCRELFFPETAHEA
uniprot
proteins
ec_number
5.4.2.8
uniprot
proteins
function
FUNCTION: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. {ECO:0000269|PubMed:18927083}.
uniprot
proteins
mass_dalton
29775
uniprot
proteins
pathway_participation
PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.
uniprot
proteins
protein_family
Eukaryotic PMM family
uniprot
proteins
pubmed
16847318
uniprot
proteins
pubmed
18927083
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16847318}.
uniprot
proteins