Siah2
entrez
20439
canonical
uniprot
Q06986
canonical
ensembl
ENSMUSG00000036432
resolver
ensp
ENSMUSP00000067496
resolver
enst
ENSMUST00000070368
resolver
genesymbol
Siah2
resolver
uniprot
Q3UEV2
resolver
uniprot_entry
Q3UEV2_MOUSE
resolver
uniprot_entry
SIAH2_MOUSE
resolver
amino_acid_sequence
MSRPSSTGPSANKPCSKQPPPPQTPHAPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGAGGGADPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:24809345, PubMed:26070566, PubMed:9637679). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:26070566, PubMed:9637679). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:26070566, PubMed:9637679). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. Promotes monoubiquitination of SNCA (By similarity). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:26070566, PubMed:9637679). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (PubMed:11257006, PubMed:14645235, PubMed:14645526, PubMed:17003045, PubMed:26070566, PubMed:9637679). Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation (By similarity). Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (PubMed:26392558). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (PubMed:24809345). Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1 (By similarity). {ECO:0000250|UniProtKB:O43255, ECO:0000269|PubMed:11257006, ECO:0000269|PubMed:14645235, ECO:0000269|PubMed:14645526, ECO:0000269|PubMed:17003045, ECO:0000269|PubMed:24809345, ECO:0000269|PubMed:26070566, ECO:0000269|PubMed:26392558, ECO:0000269|PubMed:9637679}.
uniprot
proteins
mass_dalton
34758
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-29 by DYRK2; this increases the ubiquitin ligase activity and promotes degradation of EGLN3 (By similarity). Phosphorylated at Thr-24 and Ser-29 by MAPK14, which mediates the degradation by the proteasome of EGLN3. {ECO:0000250|UniProtKB:O43255, ECO:0000269|PubMed:17003045}.
uniprot
proteins
protein_family
SINA (Seven in absentia) family
uniprot
proteins
pubmed
10681424
uniprot
proteins
pubmed
11257006
uniprot
proteins
pubmed
12417719
uniprot
proteins
pubmed
14645235
uniprot
proteins
pubmed
14645526
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17003045
uniprot
proteins
pubmed
24809345
uniprot
proteins
pubmed
26070566
uniprot
proteins
pubmed
26392558
uniprot
proteins
pubmed
7895278
uniprot
proteins
pubmed
8404535
uniprot
proteins
pubmed
9637679
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O43255}. Nucleus {ECO:0000250|UniProtKB:O43255}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250|UniProtKB:O43255}.
uniprot
proteins