Nuak2
entrez
289419
canonical
uniprot
Q66HE5
canonical
ensembl
ENSRNOG00000000034
resolver
ensp
ENSRNOP00000000039
resolver
enst
ENSRNOT00000000039
resolver
genesymbol
Nuak2
resolver
uniprot_entry
NUAK2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-212 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. {ECO:0000250, ECO:0000269|PubMed:11284715, ECO:0000269|PubMed:15893879}.
uniprot
proteins
amino_acid_sequence
MESVALHRRGNLAPSASALATESARPLADRLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGKGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLLHIRREIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERPRLNERDARHFFRQIVSALHYCHQNGIVHRDLKLENILLDASGNIKIADFGLSNLYHKGKFLQTFCGSPLYASPEIVNGKPYVGPEVDSWSLGVLLYILVHGTMPFDGQDHKTLVKQISSGAYREPCKPSDACGLIRWLLMVNPIRRATLEDVASHWWVNWGYSTRIGEQEALREGGHPSGDSGRASMADWLRRSSRPLLENGAKVCSFFKQHVPGGGSTGPGLERQHSLKKSRKENDMAQTLQNDPAEDTSSRPGKNSLKLPKGILKKKASPSSGEVQEGPQELRPVSNTPGQPVPAIPLLPRKGILKKSRQRESGYYSSPEPSESGELLDAGDVFVSGDPMEQKSPQASGRLHRKGILKLNGKFSRTALEGTAPSTFGSLDQLASPHPTARASRPSGAVSEDSILSSESFDQLDLPERLPETPLRGCVSVDNLRRLEQPPSEGLKRWWQESLGDSCFSLTDCQEVTAAYRQALGICSKLS
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway. {ECO:0000250|UniProtKB:Q9H093}.
uniprot
proteins
mass_dalton
69953
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-212 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Autophosphorylation is also possible at Thr-212. {ECO:0000250|UniProtKB:Q9H093}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SNF1 subfamily
uniprot
proteins
pubmed
11284715
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15893879
uniprot
proteins
sequence_length
630
uniprot
proteins