Cd3e
entrez
12501
canonical
uniprot
P22646
canonical
ensembl
ENSMUSG00000032093
resolver
ensp
ENSMUSP00000099896
resolver
ensp
ENSMUSP00000362848
resolver
enst
ENSMUST00000102832
resolver
genesymbol
Cd3e
resolver
uniprot
A6H6M1
resolver
uniprot_entry
A6H6M1_MOUSE
resolver
uniprot_entry
CD3E_MOUSE
resolver
amino_acid_sequence
MRWNTFWGILCLSLLAVGTCQDDAENIEYKVSISGTSVELTCPLDSDENLKWEKNGQELPQKHDKHLVLQDFSEVEDSGYYVCYTPASNKNTYLYLKARVCEYCVEVDLTAVAIIIIVDICITLGLLMVIYYWSKNRKAKAKPVTRGTGAGSRPRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRAV
uniprot
proteins
function
FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response (PubMed:9843989, PubMed:10952314, PubMed:19956738, PubMed:24470497, PubMed:24899501, PubMed:40592325). When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z (PubMed:10952314, PubMed:19956738, PubMed:24899501, PubMed:40592325). All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain (PubMed:10952314, PubMed:19956738, PubMed:24899501, PubMed:40592325). Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:10952314, PubMed:19956738, PubMed:24899501, PubMed:40592325). CD3E ITAM phosphorylation creates docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:10952314). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development (PubMed:10952314, PubMed:19956738, PubMed:24899501). Also participates in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (By similarity). In addition to its role as a TCR coreceptor, it serves as a receptor for ITPRIPL1 (By similarity). Ligand recognition inhibits T-cell activation by promoting interaction with NCK1, which prevents CD3E-ZAP70 interaction and blocks the ERK-NFkB signaling cascade and calcium influx (By similarity). {ECO:0000250|UniProtKB:P07766, ECO:0000269|PubMed:10952314, ECO:0000269|PubMed:19956738, ECO:0000269|PubMed:24470497, ECO:0000269|PubMed:24899501, ECO:0000269|PubMed:40592325, ECO:0000269|PubMed:9843989}.
uniprot
proteins
mass_dalton
21393
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. {ECO:0000250|UniProtKB:P07766}.
uniprot
proteins
pubmed
10952314
uniprot
proteins
pubmed
11439187
uniprot
proteins
pubmed
19956738
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24470497
uniprot
proteins
pubmed
24899501
uniprot
proteins
pubmed
2973066
uniprot
proteins
pubmed
3478717
uniprot
proteins
pubmed
40592325
uniprot
proteins
pubmed
9843989
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24470497}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P07766}.
uniprot
proteins
transmembrane_region
TRANSMEM 109..134; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins