Lta4h
entrez
299732
canonical
uniprot
P30349
canonical
ensembl
ENSRNOG00000004494
resolver
ensembl
ENSRNOG00055005864
resolver
ensembl
ENSRNOG00060023556
resolver
ensembl
ENSRNOG00065012260
resolver
ensp
ENSRNOP00000005930
resolver
ensp
ENSRNOP00055007292
resolver
ensp
ENSRNOP00060033760
resolver
ensp
ENSRNOP00065015279
resolver
enst
ENSRNOT00000005930
resolver
enst
ENSRNOT00055009477
resolver
enst
ENSRNOT00060040823
resolver
enst
ENSRNOT00065019930
resolver
genesymbol
Lta4h
resolver
uniprot
Q499P2
resolver
uniprot_entry
LKHA4_RAT
resolver
uniprot_sec
Q499P2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by bestatin (By similarity). Inhibited by captopril (PubMed:1544505). The epoxide hydrolase activity is restrained by suicide inactivation that involves binding of LTA4 to Tyr-379. 4-(4-benzylphenyl)thiazol-2-amine (ARM1) selectively inhibits the epoxide hydrolase activity (By similarity). {ECO:0000250|UniProtKB:P09960, ECO:0000269|PubMed:1544505}.
uniprot
proteins
amino_acid_sequence
MPEVADTCSLASPASVCRTQHLHLRCSVDFARRALTGTAALTVQSQEDNLRSLTLDTKDLTIEKVVINGQEVKYTLGESQGYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGESHPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVEKFSYQSVTTDDWKSFLYAHFKDKVDLLNQVDWNAWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAKEEDLNSFSIEDLKDLSSHQLNEFLAQVLQKAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKACMHPVTAMLVGKDLKVD
uniprot
proteins
ec_number
3.3.2.6
uniprot
proteins
ec_number
3.4.11.4
uniprot
proteins
function
FUNCTION: Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities (By similarity). Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4), as well as other lipid epoxides (PubMed:1544505). Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides. In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (By similarity). {ECO:0000250|UniProtKB:P09960, ECO:0000269|PubMed:1544505}.
uniprot
proteins
mass_dalton
69089
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; leukotriene B4 biosynthesis. {ECO:0000269|PubMed:1544505}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-416 inhibits leukotriene-A4 hydrolase activity. {ECO:0000250|UniProtKB:P09960}.
uniprot
proteins
protein_family
Peptidase M1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
1544505
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
611
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P09960}.
uniprot
proteins