Neurod2
entrez
18013
canonical
uniprot
Q62414
canonical
ensembl
ENSMUSG00000038255
resolver
ensp
ENSMUSP00000041373
resolver
ensp
ENSMUSP00000275217
resolver
enst
ENSMUST00000041685
resolver
genesymbol
Neurod2
resolver
genesymbol_syn
Ndrf
resolver
uniprot
Q3TYB2
resolver
uniprot
Q61952
resolver
uniprot
Q925V5
resolver
uniprot_entry
NDF2_MOUSE
resolver
uniprot_entry
Q3TYB2_MOUSE
resolver
uniprot_sec
Q61952
resolver
uniprot_sec
Q925V5
resolver
amino_acid_sequence
MLTRLFSEPGLLSDVPKFASWGDGDDDEPRSDKGDAPPQPPPAPGSGAPGPARAAKPVSLRGGEEIPEPTLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSKLRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYPYPCSRLAGAQCQAAGGLGGGAAHALRTHGYCAAYETLYAAAGGGGASPDYNSSEYEGPLSPPLCLNGNFSLKQDSSPDHEKSYHYSMHYSALPGSRPTGHGLVFGSSAVRGGVHSENLLSYDMHLHHDRGPMYEELNAFFHN
uniprot
proteins
function
FUNCTION: Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter. {ECO:0000269|PubMed:10648228, ECO:0000269|PubMed:14697366, ECO:0000269|PubMed:16203979, ECO:0000269|PubMed:16504944, ECO:0000269|PubMed:16730830, ECO:0000269|PubMed:18214987, ECO:0000269|PubMed:19900895, ECO:0000269|PubMed:20346398}.
uniprot
proteins
mass_dalton
41493
uniprot
proteins
mutagenesis
MUTAGEN 131..132; /note="ER->AQ: Inhibits neurons differentiation."; /evidence="ECO:0000269|PubMed:10648228
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the APC/C complex; leading to its degradation in neurons. The CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. {ECO:0000269|PubMed:19900895}.
uniprot
proteins
pubmed
10648228
uniprot
proteins
pubmed
10814830
uniprot
proteins
pubmed
11356028
uniprot
proteins
pubmed
14697366
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16203979
uniprot
proteins
pubmed
16504944
uniprot
proteins
pubmed
16730830
uniprot
proteins
pubmed
18214987
uniprot
proteins
pubmed
19900895
uniprot
proteins
pubmed
20346398
uniprot
proteins
pubmed
8607837
uniprot
proteins
pubmed
8816493
uniprot
proteins
sequence_length
383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:10648228, ECO:0000269|PubMed:16730830}.
uniprot
proteins