SLC39A9
entrez
55334
canonical
uniprot
Q9NUM3
canonical
ensembl
ENSG00000029364
resolver
ensp
ENSP00000336887
resolver
ensp
ENSP00000451833
resolver
ensp
ENSP00000452385
resolver
ensp
ENSP00000468864
resolver
enst
ENST00000031146
resolver
genesymbol
SLC39A9
resolver
genesymbol_syn
ZIP9
resolver
hgnc
HGNC:20182
resolver
uniprot
B4DDK0
resolver
uniprot
C4N9M8
resolver
uniprot
G3V5J8
resolver
uniprot
M0QX28
resolver
uniprot
Q53HN3
resolver
uniprot
Q5MJQ0
resolver
uniprot
Q6P2Q1
resolver
uniprot
Q86WY2
resolver
uniprot_entry
B4DDK0_HUMAN
resolver
uniprot_entry
C4N9M8_HUMAN
resolver
uniprot_entry
M0QX28_HUMAN
resolver
uniprot_entry
S39A9_HUMAN
resolver
uniprot_sec
G3V5J8
resolver
uniprot_sec
Q53HN3
resolver
uniprot_sec
Q5MJQ0
resolver
uniprot_sec
Q6P2Q1
resolver
uniprot_sec
Q86WY2
resolver
amino_acid_sequence
MDDFISISLLSLAMLVGCYVAGIIPLAVNFSEERLKLVTVLGAGLLCGTALAVIVPEGVHALYEDILEGKHHQASETHNVIASDKAAEKSVVHEHEHSHDHTQLHAYIGVSLVLGFVFMLLVDQIGNSHVHSTDDPEAARSSNSKITTTLGLVVHAAADGVALGAAASTSQTSVQLIVFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPVMSMVTYLGLSKSSKEALSEVNATGVAMLFSAGTFLYVATVHVLPEVGGIGHSHKPDATGGRGLSRLEVAALVLGCLIPLILSVGHQH
uniprot
proteins
function
FUNCTION: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis (PubMed:19420709, PubMed:25014355, PubMed:28219737). Participates in the zinc ions efflux out of the secretory compartments (PubMed:19420709). Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation (PubMed:23505453). Also functions as a membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1 (By similarity). This pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (By similarity). Mediates androgen-induced vascular endothelial cell proliferation through activation of an inhibitory G protein leading to the AKT1 and MAPK3/MAPK1 (Erk1/2) activation which in turn modulate inhibition (phosphorylation) of GSK3B and CCND1 transcription (PubMed:34555425). Moreover, has dual functions as a membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process (PubMed:25014355, PubMed:28219737). {ECO:0000250|UniProtKB:Q3KR82, ECO:0000250|UniProtKB:Q8BFU1, ECO:0000269|PubMed:19420709, ECO:0000269|PubMed:23505453, ECO:0000269|PubMed:25014355, ECO:0000269|PubMed:28219737, ECO:0000269|PubMed:34555425}.
uniprot
proteins
mass_dalton
32251
uniprot
proteins
protein_family
ZIP transporter (TC 2.A.5) family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19420709
uniprot
proteins
pubmed
23505453
uniprot
proteins
pubmed
25014355
uniprot
proteins
pubmed
28219737
uniprot
proteins
pubmed
34555425
uniprot
proteins
sequence_length
307
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19420709}. Cell membrane {ECO:0000269|PubMed:25014355, ECO:0000269|PubMed:34555425}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:25014355, ECO:0000269|PubMed:34555425}. Mitochondrion {ECO:0000269|PubMed:25014355, ECO:0000269|PubMed:34555425}. Nucleus {ECO:0000269|PubMed:25014355}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 35..55; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 106..126; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 176..196; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 210..230; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 244..264; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 286..306; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins