CAST
entrez
831
canonical
uniprot
P20810
canonical
ensembl
ENSG00000310517
resolver
ensp
ENSP00000312523
resolver
ensp
ENSP00000343421
resolver
ensp
ENSP00000379157
resolver
ensp
ENSP00000379158
resolver
ensp
ENSP00000425670
resolver
ensp
ENSP00000426946
resolver
ensp
ENSP00000427092
resolver
ensp
ENSP00000501659
resolver
ensp
ENSP00000501713
resolver
ensp
ENSP00000501797
resolver
ensp
ENSP00000501872
resolver
ensp
ENSP00000502136
resolver
ensp
ENSP00000502244
resolver
ensp
ENSP00000502345
resolver
ensp
ENSP00000502449
resolver
ensp
ENSP00000520668
resolver
ensp
ENSP00000639760
resolver
ensp
ENSP00000723413
resolver
enst
ENST00000504465
resolver
enst
ENST00000509903
resolver
enst
ENST00000675663
resolver
enst
ENST00000718093
resolver
genesymbol
CAST
resolver
hgnc
HGNC:1515
resolver
uniprot
A0A6Q8PH20
resolver
uniprot
A0ABB0MV66
resolver
uniprot
B7Z468
resolver
uniprot
B7Z6N0
resolver
uniprot
E9PCH5
resolver
uniprot
E9PDE4
resolver
uniprot
G5E946
resolver
uniprot
G5E9D3
resolver
uniprot
O95360
resolver
uniprot
Q05DE8
resolver
uniprot
Q59HE3
resolver
uniprot
Q7Z4K0
resolver
uniprot
Q86YM9
resolver
uniprot
Q96D08
resolver
uniprot
Q9H1Z5
resolver
uniprot_entry
A0A6Q8PH20_HUMAN
resolver
uniprot_entry
A0ABB0MV66_HUMAN
resolver
uniprot_entry
B7Z6N0_HUMAN
resolver
uniprot_entry
E9PCH5_HUMAN
resolver
uniprot_entry
E9PDE4_HUMAN
resolver
uniprot_entry
ICAL_HUMAN
resolver
uniprot_entry
Q59HE3_HUMAN
resolver
uniprot_entry
Q86YM9_HUMAN
resolver
uniprot_sec
B7Z468
resolver
uniprot_sec
G5E946
resolver
uniprot_sec
G5E9D3
resolver
uniprot_sec
O95360
resolver
uniprot_sec
Q05DE8
resolver
uniprot_sec
Q7Z4K0
resolver
uniprot_sec
Q96D08
resolver
uniprot_sec
Q9H1Z5
resolver
amino_acid_sequence
MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
uniprot
proteins
disease_involvement
DISEASE: Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK) [MIM:616295]: An autosomal recessive disease characterized by generalized, continuous shedding of the outer layers of the epidermis, leukonychia, acral punctate keratosis, cheilitis, knuckle pads with multiple hyperkeratotic micropapules involving the interphalangeal joints, and palmoplantar keratoderma. {ECO:0000269|PubMed:25683118}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
uniprot
proteins
mass_dalton
76573
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.
uniprot
proteins
protein_family
Protease inhibitor I27 (calpastatin) family
uniprot
proteins
pubmed
11978196
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1569094
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
1995645
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2407243
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
2553724
uniprot
proteins
pubmed
25683118
uniprot
proteins
pubmed
2577276
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
37316325
uniprot
proteins
pubmed
7706496
uniprot
proteins
pubmed
7951045
uniprot
proteins
sequence_length
708
uniprot
proteins