Kcnj11
entrez
83535
canonical
uniprot
P70673
canonical
ensembl
ENSRNOG00000021128
resolver
ensembl
ENSRNOG00055006933
resolver
ensembl
ENSRNOG00060011746
resolver
ensembl
ENSRNOG00065009134
resolver
ensp
ENSRNOP00000028685
resolver
ensp
ENSRNOP00055008993
resolver
ensp
ENSRNOP00060015601
resolver
ensp
ENSRNOP00065010916
resolver
enst
ENSRNOT00000028685
resolver
enst
ENSRNOT00055011425
resolver
enst
ENSRNOT00060019868
resolver
enst
ENSRNOT00065014586
resolver
genesymbol
Kcnj11
resolver
uniprot
Q62906
resolver
uniprot
Q9JM48
resolver
uniprot_entry
KCJ11_RAT
resolver
uniprot_sec
Q62906
resolver
uniprot_sec
Q9JM48
resolver
activity_regulation
ACTIVITY REGULATION: KATP channels are regulated by cytoplasmic ATP/ADP ratios; ATP inhibits the channel by closing the pore, while ADP activates the channel (By similarity). Activated by phosphatidylinositol 4,5-biphosphate (PtdIns(4,5)P2) (PubMed:38509107). {ECO:0000250|UniProtKB:Q14654, ECO:0000269|PubMed:38509107}.
uniprot
proteins
amino_acid_sequence
MLSRKGIIPEEYVLTRLAEDPTEPRYRTRERRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMVWWLIAFAHGDLAPGEGTNVPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVITLRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDSNSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDRSLLDALTLASSRGPLRKRSVAVAKAKPKFSISPDSLS
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channel that forms the pore of ATP-sensitive potassium channels (KATP), regulating potassium permeability as a function of cytoplasmic ATP and ADP concentrations in many different cells (By similarity). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). In pancreatic cells, it forms KATP channels with ABCC8/SUR1 (By similarity). Can form cardiac and smooth muscle-type KATP channels with ABCC9 (By similarity). {ECO:0000250|UniProtKB:Q14654}.
uniprot
proteins
mass_dalton
43608
uniprot
proteins
mutagenesis
MUTAGEN 52; /note="Q->R: Results in reduced sensitivity to channel inhibition by ATP and increased channel activity."; /evidence="ECO:0000269|PubMed:38509107
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity. {ECO:0000250}.
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ11 subfamily
uniprot
proteins
pubmed
38509107
uniprot
proteins
pubmed
8607800
uniprot
proteins
pubmed
8798681
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q14654}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q14654}.
uniprot
proteins
transmembrane_region
TRANSMEM 67..89; /note="Helical; Name=M1"; /evidence="ECO:0000269|PubMed:38509107, ECO:0007744|PDB:8TI1, ECO:0007744|PDB:8TI2"; TRANSMEM 143..167; /note="Helical; Name=M2"; /evidence="ECO:0000269|PubMed:38509107, ECO:0007744|PDB:8TI1, ECO:0007744|PDB:8TI2
uniprot
proteins