CDC14A
entrez
8556
canonical
uniprot
Q9UNH5
canonical
ensembl
ENSG00000079335
resolver
ensp
ENSP00000336739
resolver
ensp
ENSP00000354916
resolver
ensp
ENSP00000359142
resolver
ensp
ENSP00000489217
resolver
ensp
ENSP00000496374
resolver
enst
ENST00000635056
resolver
genesymbol
CDC14A
resolver
hgnc
HGNC:1718
resolver
uniprot
A0A0U1RQX7
resolver
uniprot
A6MA65
resolver
uniprot
B1AQ14
resolver
uniprot
B1AQ15
resolver
uniprot
B4DY86
resolver
uniprot
O43171
resolver
uniprot
O60727
resolver
uniprot
O60728
resolver
uniprot
Q52LH9
resolver
uniprot
Q59EF4
resolver
uniprot
Q8IXX0
resolver
uniprot_entry
A0A0U1RQX7_HUMAN
resolver
uniprot_entry
B4DY86_HUMAN
resolver
uniprot_entry
CC14A_HUMAN
resolver
uniprot_entry
Q59EF4_HUMAN
resolver
uniprot_sec
A6MA65
resolver
uniprot_sec
B1AQ14
resolver
uniprot_sec
B1AQ15
resolver
uniprot_sec
O43171
resolver
uniprot_sec
O60727
resolver
uniprot_sec
O60728
resolver
uniprot_sec
Q52LH9
resolver
uniprot_sec
Q8IXX0
resolver
amino_acid_sequence
MAAESGELIGACEFMKDRLYFATLRNRPKSTVNTHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKKLKSYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNRPSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLSSSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTTRNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPSLQSEYVHY
uniprot
proteins
disease_involvement
DISEASE: Deafness, autosomal recessive, 32, with or without immotile sperm (DFNB32) [MIM:608653]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNB32 is characterized by prelingual, progressive, moderate to profound sensorineural deafness. Some affected men are infertile. {ECO:0000269|PubMed:27259055, ECO:0000269|PubMed:29293958}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:29293958, ECO:0000269|PubMed:9367992}.
uniprot
proteins
mass_dalton
66574
uniprot
proteins
mutagenesis
MUTAGEN 251; /note="D->A: Loss of phosphatase activity."; /evidence="ECO:0000269|PubMed:12134069"; MUTAGEN 278; /note="C->S: Loss of phosphatase activity."; /evidence="ECO:0000269|PubMed:11598127, ECO:0000269|PubMed:12134069"; MUTAGEN 284; /note="R->A: Loss of phosphatase activity."; /evidence="ECO:0000269|PubMed:12134069"; MUTAGEN 362; /note="M->A: Inappropriate nucleolar localization; when associated with A-364."; /evidence="ECO:0000269|PubMed:11901424"; MUTAGEN 364; /note="I->A: Inappropriate nucleolar localization; when associated with A-362."; /evidence="ECO:0000269|PubMed:11901424
uniprot
proteins
protein_family
Non-receptor class CDC14 subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
10409437
uniprot
proteins
pubmed
11598127
uniprot
proteins
pubmed
11901424
uniprot
proteins
pubmed
12134069
uniprot
proteins
pubmed
15263015
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17488717
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27259055
uniprot
proteins
pubmed
29293958
uniprot
proteins
pubmed
9367992
uniprot
proteins
sequence_length
594
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9367992}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:15263015}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15263015}. Cell projection, kinocilium {ECO:0000250|UniProtKB:Q6GQT0}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q6GQT0}. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the mitotic spindle pole and at the central spindle (PubMed:11901424, PubMed:12134069, PubMed:15263015). Present along both the transient kinocilia of developing cochlear hair cells and the persistent kinocilia of vestibular hair cells (By similarity). {ECO:0000250|UniProtKB:Q6GQT0, ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:15263015}.
uniprot
proteins