POLM
entrez
27434
canonical
uniprot
Q9NP87
canonical
ensembl
ENSG00000122678
resolver
ensp
ENSP00000242248
resolver
ensp
ENSP00000335141
resolver
ensp
ENSP00000379174
resolver
ensp
ENSP00000652751
resolver
genesymbol
POLM
resolver
genesymbol_syn
polmu
resolver
hgnc
HGNC:9185
resolver
uniprot
D3DVK4
resolver
uniprot
Q6P5X8
resolver
uniprot
Q86WQ9
resolver
uniprot_entry
DPOLM_HUMAN
resolver
uniprot_sec
D3DVK4
resolver
uniprot_sec
Q6P5X8
resolver
uniprot_sec
Q86WQ9
resolver
amino_acid_sequence
MLPKRRRARVGSPSGDAASSTPPSTRFPGVAIYLVEPRMGRSRRAFLTGLARSKGFRVLDACSSEATHVVMEETSAEEAVSWQERRMAAAPPGCTPPALLDISWLTESLGAGQPVPVECRHRLEVAGPRKGPLSPAWMPAYACQRPTPLTHHNTGLSEALEILAEAAGFEGSEGRLLTFCRAASVLKALPSPVTTLSQLQGLPHFGEHSSRVVQELLEHGVCEEVERVRRSERYQTMKLFTQIFGVGVKTADRWYREGLRTLDDLREQPQKLTQQQKAGLQHHQDLSTPVLRSDVDALQQVVEEAVGQALPGATVTLTGGFRRGKLQGHDVDFLITHPKEGQEAGLLPRVMCRLQDQGLILYHQHQHSCCESPTRLAQQSHMDAFERSFCIFRLPQPPGAAVGGSTRPCPSWKAVRVDLVVAPVSQFPFALLGWTGSKLFQRELRRFSRKEKGLWLNSHGLFDPEQKTFFQAASEEDIFRHLGLEYLPPEQRNA
uniprot
proteins
ec_number
2.7.7.7
uniprot
proteins
function
FUNCTION: Catalyzes template-directed nucleotide addition during gap filling at DNA double-strand breaks (PubMed:10747040, PubMed:10982892, PubMed:12640116, PubMed:12888504, PubMed:17483519, PubMed:17915942, PubMed:26240373). Functions as a gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ) (PubMed:12640116, PubMed:17915942, PubMed:26240373). Displays reduced sugar discrimination, incorporating deoxyribonucleotides and ribonucleotides with similar efficiency on DNA primer strands, and is able to polymerize nucleotides on RNA-terminated primer strands in vitro (PubMed:12640116, PubMed:12888504). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination (By similarity). {ECO:0000250|UniProtKB:Q9JIW4, ECO:0000269|PubMed:10747040, ECO:0000269|PubMed:10982892, ECO:0000269|PubMed:12640116, ECO:0000269|PubMed:12888504, ECO:0000269|PubMed:17483519, ECO:0000269|PubMed:17915942, ECO:0000269|PubMed:26240373}.
uniprot
proteins
mass_dalton
54816
uniprot
proteins
protein_family
DNA polymerase type-X family
uniprot
proteins
pubmed
10747040
uniprot
proteins
pubmed
10982892
uniprot
proteins
pubmed
12640116
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
12888504
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17483519
uniprot
proteins
pubmed
17915942
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26240373
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UGP5}.
uniprot
proteins