Rab5if
entrez
67388
canonical
uniprot
Q9CQT9
canonical
ensembl
ENSMUSG00000027637
resolver
ensp
ENSMUSP00000029165
resolver
enst
ENSMUST00000029165
resolver
genesymbol
Rab5if
resolver
genesymbol_syn
Rcaf1
resolver
uniprot_entry
RCAF1_MOUSE
resolver
amino_acid_sequence
MSGGRRKEEPPQPQLANGALKVSVWSKVLRSDAAWDDKDEFLDVIYWFRQIIALVLGVIWGVLPLRGFLGIAGFCLINAGVLYLYFSNYLQIDEEEYGGTWELTKEGFMTSFALFMVIWIIFYTAIHYD
uniprot
proteins
function
FUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (By similarity). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (By similarity). In addition to its role in multi-pass membrane insertion, RAB5IF/OPTI also acts as an assembly factor for mitochondrial respiratory complexes (PubMed:31536960). {ECO:0000250|UniProtKB:Q9BUV8, ECO:0000269|PubMed:31536960}.
uniprot
proteins
mass_dalton
14825
uniprot
proteins
protein_family
EMC6 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
31536960
uniprot
proteins
sequence_length
129
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A0A8I3S9V6}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:31536960}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..65; /note="Helical"; /evidence="ECO:0000250|UniProtKB:A0A8I3S9V6"; TRANSMEM 67..84; /note="Helical"; /evidence="ECO:0000250|UniProtKB:A0A8I3S9V6"; TRANSMEM 104..127; /note="Helical"; /evidence="ECO:0000250|UniProtKB:A0A8I3S9V6
uniprot
proteins