Q9Z0Z5
uniprot
Q9Z0Z5
canonical
activity_regulation
ACTIVITY REGULATION: Li(+) decreases succinate transport in the presence of Na(+). {ECO:0000269|PubMed:10207168}.
uniprot
proteins
amino_acid_sequence
MAALAALAKKVWSARRLLVLLLVPLALLPILFALPPKEGRCLYVILLMAVYWCTEALPLSVTALLPIILFPFMGILPSSKVCPQYFLDTNFLFLSGLIMASAIEERNLHRRIALKVLMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIASAILKSLFGQRDTRKDLPREGEDSTAAVRGNGLRTVPTEMQFLASSEGGHAEDVEAPLELPDDSKEEEHRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLVGWLWISFLYGGMSWRGWRKKNSKLQDVAEDKAKAVIQEEFQNLGPIKFAEQAVFILFCLFAILLFSRDPKFIPGWASLFAPGFVSDAVTGVAIVTILFFFPSQKPSLKWWFDFKAPNSETEPLLSWKKAQETVPWNIILLLGGGFAMAKGCEESGLSAWIGGQLHPLEHVPPLLAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLHVHPLYLMIPGTVSCSYAFMLPVSTPPNSIAFSTGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQAIFQLGTFPDWANTHAANVTALPPALTNNTVQTL
uniprot
proteins
function
FUNCTION: High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate (PubMed:10207168, PubMed:10794676, PubMed:10992006, PubMed:12177002, PubMed:9920886). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:10207168, PubMed:10992006, PubMed:9920886). Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood (PubMed:10207168). Imports itaconate in hepatocytes leading to activation of TFEB-dependent lysosomal biogenesis involved in antibacterial innate immune response (By similarity). {ECO:0000250|UniProtKB:Q8WWT9, ECO:0000269|PubMed:10207168, ECO:0000269|PubMed:10794676, ECO:0000269|PubMed:10992006, ECO:0000269|PubMed:12177002, ECO:0000269|PubMed:9920886}.
uniprot
proteins
mass_dalton
66099
uniprot
proteins
protein_family
NADC subfamily
uniprot
proteins
protein_family
SLC13A/DASS transporter (TC 2.A.47) family
uniprot
proteins
pubmed
10207168
uniprot
proteins
pubmed
10794676
uniprot
proteins
pubmed
10992006
uniprot
proteins
pubmed
12177002
uniprot
proteins
pubmed
9920886
uniprot
proteins
sequence_length
600
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8WWT9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8WWT9}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..33; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 36..54; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 59..72; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 78..120; /note="Discontinuously helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 218..264; /note="Discontinuously helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 273..332; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 338..355; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 376..388; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 416..457; /note="Discontinuously helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 504..534; /note="Discontinuously helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 539..569; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q8WWT9
uniprot
proteins