C5ar2
entrez
445269
canonical
uniprot
Q695P6
canonical
ensembl
ENSRNOG00000049028
resolver
ensembl
ENSRNOG00055016930
resolver
ensembl
ENSRNOG00060020666
resolver
ensembl
ENSRNOG00065033945
resolver
ensp
ENSRNOP00000067721
resolver
ensp
ENSRNOP00000081314
resolver
ensp
ENSRNOP00000088875
resolver
ensp
ENSRNOP00000112307
resolver
ensp
ENSRNOP00055023162
resolver
ensp
ENSRNOP00060029474
resolver
ensp
ENSRNOP00065047969
resolver
enst
ENSRNOT00000071576
resolver
enst
ENSRNOT00000099386
resolver
enst
ENSRNOT00000102131
resolver
enst
ENSRNOT00000132357
resolver
enst
ENSRNOT00055028753
resolver
enst
ENSRNOT00060035814
resolver
enst
ENSRNOT00065058292
resolver
genesymbol
C5ar2
resolver
genesymbol_syn
C5l2
resolver
genesymbol_syn
Gpr77
resolver
uniprot
A0A8L2QZB1
resolver
uniprot
Q5XPY4
resolver
uniprot_entry
A0A8L2QZB1_RAT
resolver
uniprot_entry
C5AR2_RAT
resolver
uniprot_entry
Q5XPY4_RAT
resolver
amino_acid_sequence
MLNDTTSKDYEYEYDQEQYSDLLNVPVDCPAGNCFSNDAYLIVLLGLYSVIFLVGVPGNTLLAWVTWKESRHRLGASWFLHLTMADLLCCVSLPFLAVPIAQKGHWPYGTAGCWLLSSITVLSMYASVLLLTGLSGDLFLLAFRPSWKNADQRTCGVRVVQVSSWMLALLLTVPGAVYRKLLQEHYPPRLVCGTNYGGSVTAEVTITTVRFLFGFLVPLVFMASCHGILQRQMARRHWPLGTAVVVGFFICWTPFHLLRVIIAVASSHSPLLAWALEAEPLVTGLALAHSALNPIMFLYFGRKQLCKSLQAACHWALRDLQDEEESAVTKVSTSQEMVSEMPV
uniprot
proteins
function
FUNCTION: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. Also acts as a receptor for dearginated forms of C3a, C4a and C5a anaphylatoxin peptides (ASP/C3adesArg, C4adesArg and C5adesArg, respectively). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase. {ECO:0000250|UniProtKB:Q9P296}.
uniprot
proteins
mass_dalton
38123
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
343
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9P296}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9P296}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..67; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 79..101; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 121..143; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 156..178; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 209..231; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 244..266; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 281..300; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins