Tmem45b
entrez
235135
canonical
uniprot
Q8VCZ2
canonical
ensembl
ENSMUSG00000041737
resolver
ensp
ENSMUSP00000042313
resolver
ensp
ENSMUSP00000269834
resolver
enst
ENSMUST00000048050
resolver
genesymbol
Tmem45b
resolver
uniprot
Q3UNB2
resolver
uniprot_entry
TM45B_MOUSE
resolver
uniprot_sec
Q3UNB2
resolver
amino_acid_sequence
MANFKGHALPGSFFLIVGLWWSVKYPLKYFHHKGLKNNRLSRQQERIEIIEGAVKTLFAIIGILAEQFVPDGPHLHLYHENQWVKLMNWQHSTMYLFFGVSGLMDMITYLYFHIVPLGLDRVVLAMAVFIEGFLFYFHVHNRPPLDQHIHSLLLFGLFGAAVSISLEVILRDNIVLELFRTSLLILQGTWFWQIGFVLFPPFGRPEWDQKDMDNIMFITMCFCWHYLVALCIVAINYSLVYCFLTRVKRRAEGEIIGIQKLKSDHTYQSALLSGSDEE
uniprot
proteins
function
FUNCTION: Plays a role in innate immunity (By similarity). Essential for inflammation- and tissue injury-induced mechanical pain hypersensitivity (PubMed:36322717). {ECO:0000250|UniProtKB:Q96B21, ECO:0000269|PubMed:36322717}.
uniprot
proteins
mass_dalton
32388
uniprot
proteins
protein_family
TMEM45 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36322717
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q96B21}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q96B21}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:36322717}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 95..115; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 149..169; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 215..235; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins