SIT1
entrez
27240
canonical
uniprot
Q9Y3P8
canonical
ensembl
ENSG00000137078
resolver
ensp
ENSP00000259608
resolver
enst
ENST00000259608
resolver
genesymbol
SIT1
resolver
genesymbol_syn
SIT
resolver
hgnc
HGNC:17710
resolver
uniprot
B2RBP9
resolver
uniprot_entry
SIT1_HUMAN
resolver
uniprot_sec
B2RBP9
resolver
amino_acid_sequence
MNQADPRLRAVCLWTLTSAAMSRGDNCTDLLALGIPSITQAWGLWVLLGAVTLLFLISLAAHLSQWTRGRSRSHPGQGRSGESVEEVPLYGNLHYLQTGRLSQDPEPDQQDPTLGGPARAAEEVMCYTSLQLRPPQGRIPGPGTPVKYSEVVLDSEPKSQASGPEPELYASVCAQTRRARASFPDQAYANSQPAAS
uniprot
proteins
function
FUNCTION: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells. {ECO:0000269|PubMed:10209036}.
uniprot
proteins
mass_dalton
21126
uniprot
proteins
mutagenesis
MUTAGEN 26; /note="N->Q: Abolishes glycosylation."; /evidence="ECO:0000269|PubMed:10209036"; MUTAGEN 90; /note="Y->F: Reduces interaction with GRB2. Abolishes interaction with GRB2; when associated with F-188."; /evidence="ECO:0000269|PubMed:11433379"; MUTAGEN 127; /note="Y->F: No effect on interaction with PTPN11 or GRB2."; /evidence="ECO:0000269|PubMed:11433379"; MUTAGEN 148; /note="Y->F: Reduces interaction with PTPN11, no effect on inhibition of NF-AT activation."; /evidence="ECO:0000269|PubMed:10209036, ECO:0000269|PubMed:11433379"; MUTAGEN 169; /note="Y->F: Abolishes interaction with CSK and impairs inhibition of NF-AT activation."; /evidence="ECO:0000269|PubMed:11433379"; MUTAGEN 188; /note="Y->F: Reduces interaction with GRB2. Abolishes interaction with GRB2; when associated with F-90."; /evidence="ECO:0000269|PubMed:11433379
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines by LCK, FYN or ZAP70 upon TCR activation; which leads to the recruitment of PTPN11, GRB2 and CSK. {ECO:0000269|PubMed:10209036, ECO:0000269|PubMed:11433379}.
uniprot
proteins
pubmed
10209036
uniprot
proteins
pubmed
11433379
uniprot
proteins
pubmed
11491537
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16160011
uniprot
proteins
pubmed
19690332
uniprot
proteins
sequence_length
196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10209036}; Single-pass type I membrane protein {ECO:0000269|PubMed:10209036}.
uniprot
proteins
transmembrane_region
TRANSMEM 41..61; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins