Q9JLI4
uniprot
Q9JLI4
canonical
amino_acid_sequence
EQIMTNQMQGNKAQFNSQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLPQQGPVSNSPSQVMGIQGQVLRPPGPSPHMAQQHTDPATTANNDVNLSQMMPDVSMQQTSMVPPHVQSMQGNSASGSHFSGHGVSFNAPFGGAPNGTQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHFGVNNKQNNTNANKQKKKKPPRKKKNCHQDLNTPDSRPAGLEEVDQQSLPGEQGINLDNTGPKLPDFSNRPPGYPTQPVEQRPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQPQPQPPPPSQPQSQQQQQQQQQQQQQQMMMMLMMQQDPKSIRLPVSQNVHPPRGPLNPDSQRVPMQQSGNVPVMVSLQGPASVPPSPDKQRMPMPVNTPLGSNSRKMVYQESPQNSSS
uniprot
proteins
function
FUNCTION: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivate expression in an agonist- and AF2-dependent manner. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
45574
uniprot
proteins
mutagenesis
MUTAGEN 174..178; /note="LVNLL->AVNAA: Abolishes interaction with nuclear receptors."; /evidence="ECO:0000269|PubMed:10866662
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250}.
uniprot
proteins
pubmed
10823961
uniprot
proteins
pubmed
10866662
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins