SAP30
entrez
8819
canonical
uniprot
O75446
canonical
ensembl
ENSG00000164105
resolver
ensp
ENSP00000296504
resolver
enst
ENST00000296504
resolver
genesymbol
SAP30
resolver
hgnc
HGNC:10532
resolver
uniprot
D3DP38
resolver
uniprot_entry
SAP30_HUMAN
resolver
uniprot_sec
D3DP38
resolver
amino_acid_sequence
MNGFTPDEMSRGGDAAAAVAAVVAAAAAAASAGNGTGAGTGAEVPGAGAVSAAGPPGAAGPGPGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLPTRPGLNKAQLVEIVGCHFRSIPVNEKDTLTYFIYSVKNDKNKSDLKVDSGVH
uniprot
proteins
function
FUNCTION: Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. {ECO:0000250|UniProtKB:O88574, ECO:0000269|PubMed:9651585}.; FUNCTION: (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC. {ECO:0000269|PubMed:21221920}.
uniprot
proteins
mass_dalton
23306
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="C->A: Abolishes zinc-binding."; /evidence="ECO:0000269|PubMed:19223330"; MUTAGEN 68; /note="C->A: Retains zinc-binding."; /evidence="ECO:0000269|PubMed:19223330"; MUTAGEN 108; /note="H->A: Retains zinc-binding."; /evidence="ECO:0000269|PubMed:19223330"; MUTAGEN 112; /note="C->A: Abolishes zinc-binding."; /evidence="ECO:0000269|PubMed:19223330
uniprot
proteins
protein_family
SAP30 family
uniprot
proteins
pubmed
12670868
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15496587
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19223330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21221920
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
9651585
uniprot
proteins
pubmed
9702189
uniprot
proteins
sequence_length
220
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins