Trafd1
entrez
231712
canonical
uniprot
Q3UDK1
canonical
ensembl
ENSMUSG00000042726
resolver
ensp
ENSMUSP00000047475
resolver
ensp
ENSMUSP00000113910
resolver
ensp
ENSMUSP00000173311
resolver
ensp
ENSMUSP00000173324
resolver
ensp
ENSMUSP00000173325
resolver
ensp
ENSMUSP00000173327
resolver
ensp
ENSMUSP00000173328
resolver
ensp
ENSMUSP00000173335
resolver
genesymbol
Trafd1
resolver
genesymbol_syn
Fln29
resolver
uniprot
Q8CFI8
resolver
uniprot_entry
TRAD1_MOUSE
resolver
uniprot_sec
Q8CFI8
resolver
amino_acid_sequence
MAEFRDDQASRLCDNCKKEIPVFNFTIHEIHCQRNIGVCPVCKEPFPKSDMDIHMAAEHCQVTCKCNKKLEKRQLKQHAETECPLRLAVCQHCDLELSVVKLKEHEDYCGARTELCGSCGRNVLVKELKTHPEVCGRVEEEKRTEAAIPPEAYDEPWSQDRIWIASQLLRQIEALDPPMRLPGRPLQAFEADPFYSRTTSQRSMAAQFPVQNNLFEEQERQERNRSRQSPKDSAENNAHLDFMLALSLQNEGQATSMVEQGFWESVPEADPARAGPTSLGDIKGAADEILLPCEFCEELYPEELLIDHQTSCNPSHALRSLNTGSSSIRGVEDPGTIFQNFLQQATSNQFDTLMGLSSSAAVEDSIIIPCEFCGVQLEEEVLFYHQDQCDQRPATANHRAVEGIPAQDSQPENTSAELSRRRVKHQGDLSSGYMDDVKPESVKGPTYSMSPNRTMNNVASCNRLLNLPSGPRSDCQRSPPGVLKLNNSDSQDIRGQMRGSQNGPIASGHAPVIHSIQNLYPENFAPSFPHGSPGRYGAGGRSEGGRSSRVSPAAAGYHSRAAKAKPPKQQGAGDAEEEEE
uniprot
proteins
function
FUNCTION: Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3. {ECO:0000269|PubMed:16221674, ECO:0000269|PubMed:18849341}.
uniprot
proteins
mass_dalton
64283
uniprot
proteins
mutagenesis
MUTAGEN 294; /note="E->A: No effect on TRAF6-induced NF-kappa-B activation."; /evidence="ECO:0000269|PubMed:16221674
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16221674
uniprot
proteins
pubmed
18849341
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
580
uniprot
proteins