SLC12A8
entrez
84561
canonical
uniprot
A0AV02
canonical
ensembl
ENSG00000221955
resolver
ensp
ENSP00000377112
resolver
ensp
ENSP00000418783
resolver
genesymbol
SLC12A8
resolver
genesymbol_syn
CCC9
resolver
hgnc
HGNC:15595
resolver
uniprot
C9JJJ2
resolver
uniprot
Q68D04
resolver
uniprot
Q6I9Z2
resolver
uniprot
Q6P4C0
resolver
uniprot
Q7Z3A6
resolver
uniprot
Q86WK0
resolver
uniprot
Q8NFX9
resolver
uniprot
Q8WUI3
resolver
uniprot
Q96RF9
resolver
uniprot
Q9H5P9
resolver
uniprot_entry
S12A8_HUMAN
resolver
uniprot_sec
C9JJJ2
resolver
uniprot_sec
Q68D04
resolver
uniprot_sec
Q6I9Z2
resolver
uniprot_sec
Q6P4C0
resolver
uniprot_sec
Q7Z3A6
resolver
uniprot_sec
Q86WK0
resolver
uniprot_sec
Q8NFX9
resolver
uniprot_sec
Q8WUI3
resolver
uniprot_sec
Q96RF9
resolver
uniprot_sec
Q9H5P9
resolver
amino_acid_sequence
MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIIFVFLLGAICTREALRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTSKSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSCRSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY
uniprot
proteins
disease_involvement
DISEASE: Note=SLC12A8 has been identified as a possible susceptibility gene for psoriasis mapped to chromosome 3q21 (PSORS5).
uniprot
proteins
function
FUNCTION: Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. {ECO:0000269|PubMed:11863360}.
uniprot
proteins
mass_dalton
78239
uniprot
proteins
protein_family
SLC12A transporter family
uniprot
proteins
pubmed
11863360
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16297188
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17974005
uniprot
proteins
sequence_length
714
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 72..93; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 99..116; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 123..142; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 154..173; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 233..254; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 266..289; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 309..331; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 360..377; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 383..403; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 593..616; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 622..643; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins