Slco1c1
entrez
58807
canonical
uniprot
Q9ERB5
canonical
ensembl
ENSMUSG00000030235
resolver
ensp
ENSMUSP00000032362
resolver
ensp
ENSMUSP00000290571
resolver
enst
ENSMUST00000032362
resolver
genesymbol
Slco1c1
resolver
genesymbol_syn
Oatp1c1
resolver
genesymbol_syn
Oatpf
resolver
genesymbol_syn
Slc21a14
resolver
uniprot
Q8BX54
resolver
uniprot_entry
SO1C1_MOUSE
resolver
uniprot_sec
Q8BX54
resolver
amino_acid_sequence
MDTSSKENAHLFHKNSAQPAGGPSFTVGYPSTEEARPCCGKLKVFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGFGTMLIAVPQFFMEKYSYEKYERYSPSSNVTPSISPCYLESSSPSPSSILGKSQNKISHECVGDSSSSMWVYVFLGNLLRGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGFLSLLAAVPFWCLPKTLPRSQSRENSGSTSEKSKFIDDPIHYQMAPGDDKMKIMEMAKDFLPSLKTLFRNPVYILYLCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLLFLSLFALGCENSSVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGKNIIFSNCTCVGFAAPKSGNWSGMMGRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRCIQPQLKSFALGIYTLAVRVLAGIPAPVYFGVLIDTSCLKWGFKKCGSRGSCRLYDSHAFRHIYLGLTTLLGTVSVFLSMAVLFVLKKKYVSKHSSLITTREKIGMSSSIKKETCAARDRGLQPKYWPGKETRL
uniprot
proteins
function
FUNCTION: Mediates the Na(+)-independent high affinity transport of thyroid hormones at the plasma membrane of brain capillary endothelial cells (PubMed:15166123, PubMed:22294745, PubMed:24691440). The transport activity of substrates L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) is much greater than that of 3,3',5-triiodo-L-thyronine (T3) (PubMed:15166123). The prehormone, T4, is the major form in the circulating blood and is converted to the active form, T3, by the iodothyronine-deiodinase in peripheral organs (PubMed:15166123). T3 plays an essential role in brain development via binding to specific nuclear receptors (thyroid hormone receptor) (PubMed:15166123, PubMed:22294745). Also transports organic anions such as the conjugated steroid 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)) (PubMed:15166123). Transports T4 and estrone-3-sulfate in a pH-insensitive manner (By similarity). May serve as a drug efflux system at the blood brain barrier (By similarity). {ECO:0000250|UniProtKB:Q9EPZ7, ECO:0000250|UniProtKB:Q9NYB5, ECO:0000269|PubMed:15166123, ECO:0000269|PubMed:22294745, ECO:0000269|PubMed:24691440, ECO:0000303|PubMed:15166123, ECO:0000303|PubMed:22294745}.
uniprot
proteins
mass_dalton
78320
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
15166123
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18687783
uniprot
proteins
pubmed
22294745
uniprot
proteins
pubmed
24691440
uniprot
proteins
sequence_length
715
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15166123, ECO:0000269|PubMed:18687783}; Multi-pass membrane protein {ECO:0000269|PubMed:18687783}. Note=Expressed at the basolateral membrane of the choroid plexus epithelial cells. {ECO:0000269|PubMed:15166123}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..63; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 83..103; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 110..134; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 188..216; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 236..256; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 275..299; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 352..373; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 394..417; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 422..445; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 558..580; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 590..615; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q9NYB5"; TRANSMEM 650..667; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q9NYB5
uniprot
proteins