AHSA1
entrez
10598
canonical
uniprot
O95433
canonical
ensembl
ENSG00000100591
resolver
ensp
ENSP00000216479
resolver
ensp
ENSP00000451569
resolver
enst
ENST00000555133
resolver
genesymbol
AHSA1
resolver
genesymbol_syn
C14orf3
resolver
hgnc
HGNC:1189
resolver
uniprot
B2R9L2
resolver
uniprot
B4DUR9
resolver
uniprot
G3V438
resolver
uniprot
Q96IL6
resolver
uniprot
Q9P060
resolver
uniprot_entry
AHSA1_HUMAN
resolver
uniprot_entry
G3V438_HUMAN
resolver
uniprot_sec
B2R9L2
resolver
uniprot_sec
B4DUR9
resolver
uniprot_sec
Q96IL6
resolver
uniprot_sec
Q9P060
resolver
amino_acid_sequence
MAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTDKLKTLFLAVQVQNEEGKCEVTEVSKLDGEASINNRKGKLIFFYEWSVKLNWTGTSKSGVQYKGHVEIPNLSDENSVDEVEISVSLAKDEPDTNLVALMKEEGVKLLREAMGIYISTLKTEFTQGMILPTMNGESVDPVGQPALKTEERKAKPAPSKTQARPVGVKIPTCKITLKETFLTSPEELYRVFTTQELVQAFTHAPATLEADRGGKFHMVDGNVSGEFTDLVPEKHIVMKWRFKSWPEGHFATITLTFIDKNGETELCMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYGARLF
uniprot
proteins
function
FUNCTION: Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). {ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155}.
uniprot
proteins
mass_dalton
38274
uniprot
proteins
mutagenesis
MUTAGEN 223; /note="Y->E: Phosphomimetic mutant. Increases the binding to HSP90AA1 resulting in TSC1 dissociation from HSP90AA1."; /evidence="ECO:0000269|PubMed:29127155
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-223 enhances binding to chaperone HSP90AA1. {ECO:0000269|PubMed:29127155}.
uniprot
proteins
protein_family
AHA1 family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11554768
uniprot
proteins
pubmed
12504007
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12604615
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16696853
uniprot
proteins
pubmed
19240134
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
27353360
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29127155
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11554768}. Endoplasmic reticulum {ECO:0000269|PubMed:11554768}. Note=May transiently interact with the endoplasmic reticulum.
uniprot
proteins