RNF212B
entrez
100507650
canonical
uniprot
A8MTL3
canonical
ensembl
ENSG00000215277
resolver
ensp
ENSP00000382794
resolver
ensp
ENSP00000397830
resolver
enst
ENST00000399910
resolver
enst
ENST00000430154
resolver
genesymbol
RNF212B
resolver
genesymbol_syn
C14orf164
resolver
hgnc
HGNC:20438
resolver
uniprot_entry
R212B_HUMAN
resolver
amino_acid_sequence
MDWFHCNQCFRKDGAHFFVTSCGHIFCKKCVTLEKCAVCGTACKHLALSDNLKPQEKMFFKSPVETALQYFSHISQVWSFQKKQTDLLIAFYKHRITKLETAMQEAQQALVSQDKELSVLRKENGELKKFLAILKESPSRYQGSRSITPRPVGITSPSQSVTPRPSFQHSSQVVSRSSSAESIPYREAGFGSLGQGGRGLQGRRTPRDSYNETPSPASTHSLSYRTSSASSGQGIFSFRPSPNGHSGHTRVLTPNNFAQRESTTTLESLPSFQLPVLQTLYQQRRHMGLPSGREAWTTSR
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Ubiquitin E3 ligase that acts as a crucial factor for crossing-over (CO) formation during meiosis. Essential for normal prophase I progression and for ensuring appropriate CO designation in meiosis. Recruits key components of the cross-over machinery either directly ou indirectly, leading to the activation of the MutL-gamma complex. The function of RNF212B in CO designation is dependent on its catalytic activity. {ECO:0000250|UniProtKB:D3Z423}.
uniprot
proteins
mass_dalton
33570
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:D3Z423}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000250|UniProtKB:D3Z423}.
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
37124137
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:D3Z423}. Note=Colocalizes with RNF212. {ECO:0000250|UniProtKB:D3Z423}.
uniprot
proteins