KCNE3
entrez
10008
canonical
uniprot
Q9Y6H6
canonical
ensembl
ENSG00000175538
resolver
ensp
ENSP00000310557
resolver
ensp
ENSP00000433633
resolver
ensp
ENSP00000545823
resolver
ensp
ENSP00000545824
resolver
ensp
ENSP00000599511
resolver
ensp
ENSP00000599512
resolver
ensp
ENSP00000599513
resolver
enst
ENST00000310128
resolver
enst
ENST00000525550
resolver
enst
ENST00000875764
resolver
enst
ENST00000875765
resolver
enst
ENST00000929452
resolver
enst
ENST00000929453
resolver
enst
ENST00000929454
resolver
genesymbol
KCNE3
resolver
genesymbol_syn
DKFZp781H21101
resolver
hgnc
HGNC:6243
resolver
uniprot
Q6IAE6
resolver
uniprot_entry
KCNE3_HUMAN
resolver
uniprot_entry
Q6IAE6_HUMAN
resolver
amino_acid_sequence
METTNGTETWYESLHAVLKALNATLHSNLLCRPGPGLGPDNQTEERRASLPGRDDNSYMYILFVMFLFAVTVGSLILGYTRSRKVDKRSDPYHVYIKNRVSMI
uniprot
proteins
disease_involvement
DISEASE: Brugada syndrome 6 (BRGDA6) [MIM:613119]: A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. {ECO:0000269|PubMed:19122847}. Note=The gene represented in this entry may be involved in disease pathogenesis.
uniprot
proteins
function
FUNCTION: Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE3 beta subunit modulates the gating kinetics and enhances stability of the channel complex (PubMed:10646604, PubMed:11207363, PubMed:12954870). Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:12954870). Associates with KCNC4/Kv3.4 alpha subunit to form the subthreshold Kv channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells (PubMed:11207363). Association with KCNQ1/KCLQT1 alpha subunit may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship (By similarity). {ECO:0000250|UniProtKB:Q9JJV7, ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:11207363, ECO:0000269|PubMed:12954870}.
uniprot
proteins
mass_dalton
11710
uniprot
proteins
mutagenesis
MUTAGEN 90; /note="D->N: Decreases current 4-fold in KCNH2/KCNE3 channel."; /evidence="ECO:0000269|PubMed:11874988
uniprot
proteins
protein_family
Potassium channel KCNE family
uniprot
proteins
pubmed
10646604
uniprot
proteins
pubmed
11104781
uniprot
proteins
pubmed
11207363
uniprot
proteins
pubmed
11874988
uniprot
proteins
pubmed
12414843
uniprot
proteins
pubmed
12954870
uniprot
proteins
pubmed
14504341
uniprot
proteins
pubmed
15037716
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19122847
uniprot
proteins
pubmed
19306396
uniprot
proteins
pubmed
20533308
uniprot
proteins
pubmed
31883792
uniprot
proteins
sequence_length
103
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12954870}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12954870}. Perikaryon {ECO:0000269|PubMed:12954870}. Cell projection, dendrite {ECO:0000269|PubMed:12954870}. Membrane raft {ECO:0000269|PubMed:20533308}. Note=Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal neurons. {ECO:0000269|PubMed:12954870}.
uniprot
proteins
transmembrane_region
TRANSMEM 57..77; /note="Helical"; /evidence="ECO:0000269|PubMed:31883792, ECO:0007744|PDB:6V01
uniprot
proteins