SLAIN2
entrez
57606
canonical
uniprot
Q9P270
canonical
ensembl
ENSG00000109171
resolver
ensp
ENSP00000264313
resolver
ensp
ENSP00000425923
resolver
enst
ENST00000264313
resolver
genesymbol
SLAIN2
resolver
genesymbol_syn
KIAA1458
resolver
hgnc
HGNC:29282
resolver
uniprot
A0A024R9T6
resolver
uniprot
A0A158RFV0
resolver
uniprot
A8K4P1
resolver
uniprot
Q8N5R3
resolver
uniprot_entry
A0A024R9T6_HUMAN
resolver
uniprot_entry
SLAI2_HUMAN
resolver
uniprot_sec
A0A158RFV0
resolver
uniprot_sec
A8K4P1
resolver
uniprot_sec
Q8N5R3
resolver
amino_acid_sequence
MEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGSLGPGSPVRAGASIPSSGAASPRGFPLGLSAKSGGGPGSGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASAIPSPGKFRSPAAPSPLALRQPVKAFSNHGSGSPGSQEITQLTQTTSSPGPPMVQSTVSANPPSNINSATLTRPAGTTAMRSGLPRPSAPSAGGIPVPRSKLAQPVRRSLPAPKTYGSMKDDSWKDGCY
uniprot
proteins
function
FUNCTION: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}.
uniprot
proteins
mass_dalton
62543
uniprot
proteins
mutagenesis
MUTAGEN 581; /note="Missing: Abolishes interaction with CLIP1."; /evidence="ECO:0000269|PubMed:21646404
uniprot
proteins
post_translational_modification
PTM: Is highly phosphorylated during mitosis, but not during interphase. The highly phosphorylated form does not localize at microtubule plus ends and does not interact with MAPRE1 or CKAP5. {ECO:0000269|PubMed:21646404}.
uniprot
proteins
protein_family
SLAIN motif-containing family
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21646404
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
581
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. Detected at the plus end of growing microtubules.
uniprot
proteins