NUDC
entrez
10726
canonical
uniprot
Q9Y266
canonical
ensembl
ENSG00000090273
resolver
ensp
ENSP00000319664
resolver
enst
ENST00000321265
resolver
genesymbol
NUDC
resolver
hgnc
HGNC:8045
resolver
uniprot
Q5QP31
resolver
uniprot
Q5QP35
resolver
uniprot
Q9H0N2
resolver
uniprot
Q9Y2B6
resolver
uniprot_entry
NUDC_HUMAN
resolver
uniprot_sec
Q5QP31
resolver
uniprot_sec
Q5QP35
resolver
uniprot_sec
Q9H0N2
resolver
uniprot_sec
Q9Y2B6
resolver
amino_acid_sequence
MGGEQEEERFDGMLLAMAQQHEGGVQELVNTFFSFLRRKTDFFIGGEEGMAEKLITQTFSHHNQLAQKTRREKRARQEAERREKAERAARLAKEAKSETSGPQIKELTDEEAERLQLEIDQKKDAENHEAQLKNGSLDSPGKQDTEEDEEEDEKDKGKLKPNLGNGADLPNYRWTQTLSELDLAVPFCVNFRLKGKDMVVDIQRRHLRVGLKGQPAIIDGELYNEVKVEESSWLIEDGKVVTVHLEKINKMEWWSRLVSSDPEINTKKINPENSKLSDLDSETRSMVEKMMYDQRQKSMGLPTSDEQKKQEILKKFMDQHPEMDFSKAKFN
uniprot
proteins
function
FUNCTION: Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}.
uniprot
proteins
mass_dalton
38243
uniprot
proteins
mutagenesis
MUTAGEN 274; /note="S->A: Abolishes phosphorylation by PLK1; when associated with A-326."; /evidence="ECO:0000269|PubMed:12852857"; MUTAGEN 326; /note="S->A: Abolishes phosphorylation by PLK1; when associated with A-274."; /evidence="ECO:0000269|PubMed:12852857
uniprot
proteins
post_translational_modification
PTM: Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases. {ECO:0000269|PubMed:12852857}.
uniprot
proteins
protein_family
NudC family
uniprot
proteins
pubmed
10210332
uniprot
proteins
pubmed
10453739
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12679384
uniprot
proteins
pubmed
12852857
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22159412
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25789526
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Nucleus {ECO:0000269|PubMed:10210332}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25789526}. Midbody {ECO:0000269|PubMed:25789526}. Note=In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern. Localizes to the mitotic spindle in a EML4-dependent manner (PubMed:25789526). {ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:25789526}.
uniprot
proteins