Cpap
entrez
219103
canonical
uniprot
Q569L8
canonical
ensembl
ENSMUSG00000064128
resolver
ensp
ENSMUSP00000065949
resolver
ensp
ENSMUSP00000153013
resolver
enst
ENSMUST00000065302
resolver
enst
ENSMUST00000225951
resolver
genesymbol
Cpap
resolver
genesymbol_syn
Cenpj
resolver
uniprot
E9QLP3
resolver
uniprot_entry
CPAP_MOUSE
resolver
uniprot_sec
E9QLP3
resolver
amino_acid_sequence
MFLMPTSSELNSGQNFLTQWMTSPSRAGVILNRGFPILEADDKQAATNVSTSFPAKATHFSNSFSISSEEDSFHEEQKLEAGGPYKPWSENPEAPPVFPSVRKEPIASRQDAPGCQEDNNNDLTPHLESEFKEVANKNPLFKKLEQLKEIQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSAQHAFPGTLLPDDQSQKHRSPGDLTLPPHSYSNPTQENSCASNVLPDEQSNFCRATQDSVLTSKNASDLFYESQYQEAHVKRNDLKEESPAHPSGEGALPRWEKKMGRSQEGKDVNLQKCGDSSEVVNIDERPIKAAVREKQQTFEDYLEEQIQLEERELRQKQLQEAEGPLLAKTKPKQPFLKRGEGLARFTNAKSKFQKGKESKLASTQSPSEDQPGSKVDRQHLQRKTALINKDLCAETPTVKKDSKARPKAGFASLRQKPKVTKTNMRESLSPPGLKVQTGKKRDGQFRHQVKGERNAHASNKENVPACIKPWDAGCKMWSKTQGRERLPLSTGPVGCVVSRSPIRETDRETESSLDFSLQKKLEIWEREKEKENLELDEFLFLERAADEISFSSNSSFVLRILERDQQICDGHRLSSTPVKAVQQREAQQADPRGQSNCSEIPRYGVAHENESECEAMLLSWGSGSPDGLRELSCKRSMKAFQTSTSEIQSQWDARDDGVANSDSSTESEEQHDITIKPSTEVGDRVFSNREDSPQVCDAKGPIRDTGAQEDKWRDADLDLSDKECSSDESVIVESLNNKVLEPLRLPSSQAGSKIDFDDERSWTDLEENPYEHGVIHREEAIYGTPQTQCHSKSEGCVLDKTIKRKIAPVKKGEDFKCDRRISPPPPSDLMVKFFPSLKPKPKLDSHLENESKLNLSQDQPPEFMVCFIGDSVRSQVLREKVTELESEIEKFKAENTSLAKLRIERESALEKLRKEIADFEQQKARELARIEEYRKEETRKLQKERKVFEKYTAAARTFPDKKEREEIQALKQQIADLQEDLKRKETKWSSTQSRLRSQIEMLVKENTDLREEIKVMERFRLDAWKRAEAMENSPKACQYMMATKKDESMNSSFQFQKSHVSSGVQVEKYKKKYLPAQGNLSRRIKSAPPRDLGSSDKGQAALPREPLQQVNFPDLEYKNKEEKEEEIQGEISHPDGKVEKIYKNGRRVVLFPNGTRKEVSADGKSVTVTFFNGDVKQVMPDERVVYYYAAAQTTHTTYPEGLEVLHFSSGQIEKHFPDGRKEITFPDQTIKTLFADGQEESIFPDGTIVRVQRDGNKIIEFNNGQRELHTAQFKRREYPDGTVKTVYANGHQETKYTSGRVRVKDKDGNVLMDTEM
uniprot
proteins
function
FUNCTION: Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (By similarity). {ECO:0000250|UniProtKB:Q9HC77}.
uniprot
proteins
mass_dalton
153079
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-577 and Ser-583 by PLK2 is required for procentriole formation and centriole elongation. Phosphorylation by PLK2 oscillates during the cell cycle: it increases at G1/S transition and decreases during the exit from mitosis. Phosphorylation at Ser-583 is also mediated by PLK4 but is not a critical step in PLK4 function in procentriole assembly. {ECO:0000250|UniProtKB:Q9HC77}.
uniprot
proteins
protein_family
TCP10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
1344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9HC77}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9HC77}. Note=Localized within the center of microtubule asters. During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles (By similarity). {ECO:0000250|UniProtKB:Q9HC77}.
uniprot
proteins