LMCD1
entrez
29995
canonical
uniprot
Q9NZU5
canonical
ensembl
ENSG00000071282
resolver
ensp
ENSP00000157600
resolver
ensp
ENSP00000380542
resolver
ensp
ENSP00000396515
resolver
ensp
ENSP00000411222
resolver
enst
ENST00000397386
resolver
enst
ENST00000426878
resolver
genesymbol
LMCD1
resolver
hgnc
HGNC:6633
resolver
uniprot
B4DEY6
resolver
uniprot
B4DG80
resolver
uniprot
B7Z6R5
resolver
uniprot
F6UYK2
resolver
uniprot
H7C3D2
resolver
uniprot_entry
B4DEY6_HUMAN
resolver
uniprot_entry
B7Z6R5_HUMAN
resolver
uniprot_entry
F6UYK2_HUMAN
resolver
uniprot_entry
H7C3D2_HUMAN
resolver
uniprot_entry
LMCD1_HUMAN
resolver
uniprot_sec
B4DG80
resolver
amino_acid_sequence
MAKVAKDLNPGVKKMSLGQLQSARGVACLGCKGTCSGFEPHSWRKICKSCKCSQEDHCLTSDLEDDRKIGRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMTNPIATGKDPTFDTITYEWAPPGVTQKLGLQYMELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLLENELKLMEEFVKQYKSEALGVGEVALPGQGGLPKEEGKQQEKPEGAETTAATTNGSLSDPSKEVEYVCELCKGAAPPDSPVVYSDRAGYNKQWHPTCFVCAKCSEPLVDLIYFWKDGAPWCGRHYCESLRPRCSGCDEIIFAEDYQRVEDLAWHRKHFVCEGCEQLLSGRAYIVTKGQLLCPTCSKSKRS
uniprot
proteins
function
FUNCTION: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. {ECO:0000250, ECO:0000269|PubMed:20026769}.
uniprot
proteins
mass_dalton
40833
uniprot
proteins
pubmed
10662546
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16199866
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
20026769
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=May shuttle between the cytoplasm and the nucleus. {ECO:0000250}.
uniprot
proteins