SLC25A30
entrez
253512
canonical
uniprot
Q5SVS4
canonical
ensembl
ENSG00000174032
resolver
ensp
ENSP00000429168
resolver
ensp
ENSP00000443542
resolver
ensp
ENSP00000527588
resolver
ensp
ENSP00000527589
resolver
ensp
ENSP00000675139
resolver
ensp
ENSP00000675140
resolver
ensp
ENSP00000675141
resolver
genesymbol
SLC25A30
resolver
genesymbol_syn
KMCP1
resolver
genesymbol_syn
UCP6
resolver
hgnc
HGNC:27371
resolver
uniprot
B2RN96
resolver
uniprot
B3KSR0
resolver
uniprot
B3KTE8
resolver
uniprot
B4DZK3
resolver
uniprot
F5H8H8
resolver
uniprot_entry
B3KSR0_HUMAN
resolver
uniprot_entry
B3KTE8_HUMAN
resolver
uniprot_entry
KMCP1_HUMAN
resolver
uniprot_sec
B2RN96
resolver
uniprot_sec
B4DZK3
resolver
uniprot_sec
F5H8H8
resolver
activity_regulation
ACTIVITY REGULATION: Increased activity at pH 6.0 (PubMed:31356773). sulfate/sulfate exchange activity is inhibited strongly by pyridoxal 5'-phosphate, bathophenanthroline and the organic mercurials mersalyl, p-chloromercuribenzoate and HgCl2 (PubMed:31356773). {ECO:0000269|PubMed:31356773}.
uniprot
proteins
amino_acid_sequence
MSALNWKPFVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLKALYSGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDETLPINVICGILSGVISSTIANPTDVLKIRMQAQSNTIQGGMIGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVGVELPVYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQRVLRDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKKLDL
uniprot
proteins
function
FUNCTION: Antiporter that transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate (PubMed:31356773). The sulfate/sulfate exchange is much higher than the phosphate/phosphate and malate/malate exchanges (PubMed:31356773). The transport affinities is higher for sulfate and thiosulfate than for any other substrate (PubMed:31356773). May catalyze the export of sulfite and thiosulfate (the hydrogen sulfide degradation products) from the mitochondria, thereby modulating the level of the hydrogen sulfide (Probable). Also may mediate a very low unidirectional transport of sulfate, phosphate and (S)-malate (PubMed:31356773). {ECO:0000250, ECO:0000269|PubMed:31356773, ECO:0000305|PubMed:31356773}.
uniprot
proteins
mass_dalton
32475
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26387735
uniprot
proteins
pubmed
31356773
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9CR58}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..26; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 71..89; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 105..124; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 164..183; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 264..283; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins