Bpnt2
entrez
242291
canonical
uniprot
Q80V26
canonical
ensembl
ENSMUSG00000066324
resolver
ensp
ENSMUSP00000082013
resolver
enst
ENSMUST00000084949
resolver
genesymbol
Bpnt2
resolver
genesymbol_syn
Impa3
resolver
genesymbol_syn
Impad1
resolver
uniprot
A6H6P6
resolver
uniprot_entry
IMPA3_MOUSE
resolver
uniprot_sec
A6H6P6
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by lithium. {ECO:0000269|PubMed:18695242}.
uniprot
proteins
amino_acid_sequence
MAPMGIRLSPLGVAVFFLLGLGVLYHLYSGFLAGRFSLFGLGSEPAAGEAEVASDGGTVDLREMLAVAVLAAERGGDEVRRVRESNVLHEKSKGKTREGADDKMTSGDVLSNRKMFYLLKTAFPNVQINTEEHVDASDKEVIVWNRKIPEDILKEIAAPKEVPAESVTVWIDPLDATQEYTEDLRKYVTTMVCVAVNGKPVLGVIHKPFSEYTAWAMVDGGSNVKARSSYNEKTPKIIVSRSHAGMVKQVALQTFGNQTSIIPAGGAGYKVLALLDVPDMTQEKADLYIHVTYIKKWDICAGNAILKALGGHMTTLNGEEISYTGSDGIEGGLLASIRMNHQALVRKLPDLEKSGH
uniprot
proteins
ec_number
3.1.3.7
uniprot
proteins
function
FUNCTION: Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate (PubMed:18695242). May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation (PubMed:18695242). Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4. {ECO:0000269|PubMed:18695242}.
uniprot
proteins
mass_dalton
38616
uniprot
proteins
pathway_participation
PATHWAY: Sulfur metabolism. {ECO:0000305|PubMed:18695242}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated (By similarity). Contains N-linked glycan resistant to endoglycosydase H (By similarity). {ECO:0000250|UniProtKB:Q9NX62}.
uniprot
proteins
protein_family
Inositol monophosphatase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18695242
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:18695242}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18695242}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9NX62}. Note=The catalytic core is predicted to reside within the Golgi lumen. {ECO:0000250|UniProtKB:Q9NX62}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins