Pde4d
entrez
238871
canonical
uniprot
Q01063
canonical
ensembl
ENSMUSG00000021699
resolver
ensp
ENSMUSP00000073742
resolver
ensp
ENSMUSP00000112991
resolver
ensp
ENSMUSP00000113024
resolver
ensp
ENSMUSP00000113488
resolver
ensp
ENSMUSP00000113610
resolver
ensp
ENSMUSP00000114089
resolver
ensp
ENSMUSP00000119583
resolver
ensp
ENSMUSP00000121592
resolver
enst
ENSMUST00000117420
resolver
enst
ENSMUST00000119507
resolver
enst
ENSMUST00000120671
resolver
genesymbol
Pde4d
resolver
uniprot
A2RSH1
resolver
uniprot
A6XDA7
resolver
uniprot
A6XDB0
resolver
uniprot
B2KF58
resolver
uniprot
B2KF84
resolver
uniprot
E9PVU7
resolver
uniprot
F7BCV6
resolver
uniprot
Q6TRH9
resolver
uniprot
Q8C4Q7
resolver
uniprot
Q8CG05
resolver
uniprot_entry
A2RSH1_MOUSE
resolver
uniprot_entry
A6XDA7_MOUSE
resolver
uniprot_entry
A6XDB0_MOUSE
resolver
uniprot_entry
B2KF84_MOUSE
resolver
uniprot_entry
E9PVU7_MOUSE
resolver
uniprot_entry
F7BCV6_MOUSE
resolver
uniprot_entry
PDE4D_MOUSE
resolver
uniprot_sec
B2KF58
resolver
uniprot_sec
Q6TRH9
resolver
uniprot_sec
Q8C4Q7
resolver
uniprot_sec
Q8CG05
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by rolipram. Activated by phosphatidic acid (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MERDTCDVLSRSKSASEETLHSCNEEEDPFRGMEPYLVRRLSSRSIQLPPLAFRQLEQADLRSESENIPRPTSLPLKILPLIAVTSADSSGFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSCIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDQEEGRQGQTEKFQFELTLEEDCESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVAEEESQPETCVPDDCCPDT
uniprot
proteins
ec_number
3.1.4.53
uniprot
proteins
function
FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000250}.
uniprot
proteins
mass_dalton
84563
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
uniprot
proteins
post_translational_modification
PTM: Sumoylation of long isoforms by PIAS4 augments their activation by PKA phosphorylation and represses their inhibition by ERK phosphorylation. {ECO:0000250}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE4 subfamily
uniprot
proteins
pubmed
12834813
uniprot
proteins
pubmed
1326532
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17244609
uniprot
proteins
pubmed
18268335
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
747
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Apical cell membrane {ECO:0000250}. Note=Colocalized with SHANK2 to the apical membrane of colonic crypt cells (By similarity). Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome. {ECO:0000250}.
uniprot
proteins