Lipc
entrez
15450
canonical
uniprot
P27656
canonical
ensembl
ENSMUSG00000032207
resolver
ensp
ENSMUSP00000034731
resolver
ensp
ENSMUSP00000149185
resolver
enst
ENSMUST00000034731
resolver
enst
ENSMUST00000216798
resolver
genesymbol
Lipc
resolver
genesymbol_syn
Hpl
resolver
uniprot
A0A1L1SQT9
resolver
uniprot
Q3TYU0
resolver
uniprot
Q8VC44
resolver
uniprot_entry
A0A1L1SQT9_MOUSE
resolver
uniprot_entry
LIPC_MOUSE
resolver
uniprot_entry
Q3TYU0_MOUSE
resolver
uniprot_sec
Q8VC44
resolver
amino_acid_sequence
MGNPLQISIFLVFCIFIQSSACGQGVGTEPFGRSLGATEASKPLKKPETRFLLFQDENDRLGCRLRPQHPETLQECGFNSSQPLIMIIHGWSVDGLLENWIWKIVSALKSRQSQPVNVGLVDWISLAYQHYTIAVQNTRIVGQDVAALLLWLEESAKFSRSKVHLIGYSLGAHVSGFAGSSMDGKNKIGRITGLDPAGPMFEGTSPNERLSPDDANFVDAIHTFTREHMGLSVGIKQPIAHYDFYPNGGSFQPGCHFLELYKHIAEHGLNAITQTIKCAHERSVHLFIDSLQHSDLQSIGFQCSDMGSFSQGLCLSCKKGRCNTLGYDIRKDRSGKSKRLFLITRAQSPFKVYHYQFKIQFINQIEKPVEPTFTMSLLGTKEEIKRIPITLGEGITSNKTYSFLITLDKDIGELILLKFKWENSAVWANVWNTVQTIMLWGIEPHHSGLILKTIWVKAGETQQRMTFCPENLDDLQLHPSQEKVFVNCEVKSKRLTESKEQMSQETHAKK
uniprot
proteins
ec_number
3.1.1.3
uniprot
proteins
ec_number
3.1.1.32
uniprot
proteins
ec_number
3.1.1.5
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (By similarity). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (By similarity). {ECO:0000250|UniProtKB:P07867, ECO:0000250|UniProtKB:P11150}.
uniprot
proteins
mass_dalton
57389
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
Lipase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1840530
uniprot
proteins
pubmed
2025643
uniprot
proteins
sequence_length
510
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P11150}.
uniprot
proteins