Rad54l
entrez
19366
canonical
uniprot
P70270
canonical
ensembl
ENSMUSG00000028702
resolver
ensp
ENSMUSP00000099765
resolver
ensp
ENSMUSP00000099766
resolver
enst
ENSMUST00000102704
resolver
enst
ENSMUST00000102705
resolver
genesymbol
Rad54l
resolver
genesymbol_syn
Rad54
resolver
uniprot
Q8BSR5
resolver
uniprot
Q8C2C4
resolver
uniprot
Q8K3D4
resolver
uniprot_entry
RAD54_MOUSE
resolver
uniprot_sec
Q8BSR5
resolver
uniprot_sec
Q8C2C4
resolver
uniprot_sec
Q8K3D4
resolver
amino_acid_sequence
MRRSLAPSQLARRKPEDRSSDDEDWQPGTVTPKKRKSSSETQVQECFLSPFRKPLTQLLNRPPCLDSSQHEAFIRSILSKPFKVPIPNYQGPLGSRALGLKRAGVRRALHDPLEEGALVLYEPPPLSAHDQLKLDKEKLPVHVVVDPILSKVLRPHQREGVKFLWECVTSRRIPGSHGCIMADEMGLGKTLQCITLMWTLLRQSPECKPEIEKAVVVSPSSLVKNWYNEVEKWLGGRIQPLAIDGGSKDEIDRKLEGFMNQRGARVPSPILIISYETFRLHVGVLKKGNVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVHFVNSGILGTAHEFKKHFELPILKSRDAAASEADRQRGEERLRELIGIVNRCLIRRTSDILSKYLPVKIEQVVCCRLTPLQTELYKRFLRQAKPEEELREGKMSVSSLSSITSLKKLCNHPALIYDKCVAEEDGFEGTLGIFPPGYNSKAVEPQLSGKMLVLDYILAVTRSRSSDKVVLVSNYTQTLDLFEKLCRVRRYLYVRLDGTMSIKKRAKVVERFNSPSSPDFVFMLSSKAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKICYIYRLLSAGTIEEKIFQRQSHKKALSSCVVDEEQDVERHFSLGELKELFTLDEASLSDTHDRLHCRRCVNNRQVWPPPDGSDCTSDLAQWNHSTDKRGLQDEVLQAAWDASSTAITFVFHQRSHEEQRGLH
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Multifunctional ATPase that plays a role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:10209103, PubMed:10757799, PubMed:12218123, PubMed:12531026, PubMed:15175260). Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity). {ECO:0000250|UniProtKB:P32863, ECO:0000250|UniProtKB:Q92698, ECO:0000269|PubMed:10209103, ECO:0000269|PubMed:10757799, ECO:0000269|PubMed:12218123, ECO:0000269|PubMed:12531026, ECO:0000269|PubMed:15175260}.
uniprot
proteins
mass_dalton
84694
uniprot
proteins
post_translational_modification
PTM: Acetylated. Acetylation promotes interaction with BRD9, and subsequently with RAD54, which is essential for homologous recombination (HR). {ECO:0000250|UniProtKB:Q92698}.; PTM: Phosphorylated. Phosphorylation at Ser-572 by NEK1 specifically in G2 phase allows efficient removal of RAD51 filaments from DNA. {ECO:0000250|UniProtKB:Q92698}.
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
10209103
uniprot
proteins
pubmed
10757799
uniprot
proteins
pubmed
12218123
uniprot
proteins
pubmed
12531026
uniprot
proteins
pubmed
12897131
uniprot
proteins
pubmed
15175260
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
8805304
uniprot
proteins
pubmed
9108475
uniprot
proteins
sequence_length
747
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92698}.
uniprot
proteins