MID1
entrez
4281
canonical
uniprot
O15344
canonical
ensembl
ENSG00000101871
resolver
ensp
ENSP00000312678
resolver
ensp
ENSP00000370156
resolver
ensp
ENSP00000370157
resolver
ensp
ENSP00000370164
resolver
ensp
ENSP00000391154
resolver
ensp
ENSP00000484712
resolver
ensp
ENSP00000508734
resolver
ensp
ENSP00000509730
resolver
ensp
ENSP00000509925
resolver
enst
ENST00000616003
resolver
enst
ENST00000687008
resolver
enst
ENST00000689773
resolver
enst
ENST00000690004
resolver
genesymbol
MID1
resolver
genesymbol_syn
FXY
resolver
genesymbol_syn
RNF59
resolver
genesymbol_syn
TRIM18
resolver
genesymbol_syn
XPRF
resolver
hgnc
HGNC:7095
resolver
uniprot
A0A087X255
resolver
uniprot
A0A8I5KPE0
resolver
uniprot
A0A8I5KR14
resolver
uniprot
B2RCG2
resolver
uniprot
O75361
resolver
uniprot
Q9BZX5
resolver
uniprot_entry
A0A087X255_HUMAN
resolver
uniprot_entry
A0A8I5KPE0_HUMAN
resolver
uniprot_entry
A0A8I5KR14_HUMAN
resolver
uniprot_entry
TRI18_HUMAN
resolver
uniprot_sec
B2RCG2
resolver
uniprot_sec
O75361
resolver
uniprot_sec
Q9BZX5
resolver
amino_acid_sequence
METLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCATNESVESITAFQCPTCRHVITLSQRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSETRRERAFDANTMTSAEKVLCQFCDQDPAQDAVKTCVTCEVSYCDECLKATHPNKKPFTGHRLIEPIPDSHIRGLMCLEHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSERYDKLKQNLESNLTNLIKRNTELETLLAKLIQTCQHVEVNASRQEAKLTEECDLLIEIIQQRRQIIGTKIKEGKVMRLRKLAQQIANCKQCIERSASLISQAEHSLKENDHARFLQTAKNITERVSMATASSQVLIPEINLNDTFDTFALDFSREKKLLECLDYLTAPNPPTIREELCTASYDTITVHWTSDDEFSVVSYELQYTIFTGQANVVSLCNSADSWMIVPNIKQNHYTVHGLQSGTKYIFMVKAINQAGSRSSEPGKLKTNSQPFKLDPKSAHRKLKVSHDNLTVERDESSSKKSHTPERFTSQGSYGVAGNVFIDSGRHYWEVVISGSTWYAIGLAYKSAPKHEWIGKNSASWALCRCNNNWVVRHNSKEIPIEPAPHLRRVGILLDYDNGSIAFYDALNSIHLYTFDVAFAQPVCPTFTVWNKCLTIITGLPIPDHLDCTEQLP
uniprot
proteins
disease_involvement
DISEASE: Opitz GBBB syndrome (GBBB) [MIM:300000]: A congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, cleft lip/palate, laryngotracheoesophageal abnormalities, imperforate anus, developmental delay and congenital heart defects. {ECO:0000269|PubMed:11030761, ECO:0000269|PubMed:15558842, ECO:0000269|PubMed:9354791, ECO:0000269|PubMed:9718340}. Note=The disease is caused by variants affecting the gene represented in this entry. MID1 mutations produce proteins with a decreased affinity for microtubules.
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that promotes the monoubiquitination of IGBP1, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination (PubMed:11685209, PubMed:22613722). {ECO:0000269|PubMed:10400985, ECO:0000269|PubMed:11685209, ECO:0000269|PubMed:22613722}.
uniprot
proteins
mass_dalton
75251
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues. {ECO:0000269|PubMed:11806752}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
10077590
uniprot
proteins
pubmed
10400985
uniprot
proteins
pubmed
11030761
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
11685209
uniprot
proteins
pubmed
11806752
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15558842
uniprot
proteins
pubmed
16529770
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22613722
uniprot
proteins
pubmed
22629402
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
40821731
uniprot
proteins
pubmed
9354791
uniprot
proteins
pubmed
9425238
uniprot
proteins
pubmed
9718340
uniprot
proteins
pubmed
9722948
uniprot
proteins
sequence_length
667
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10077590}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10077590}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10077590}. Note=Microtubule-associated. It is associated with microtubules throughout the cell cycle, co-localizing with cytoplasmic fibers in interphase and with the mitotic spindle and midbodies during mitosis and cytokinesis.
uniprot
proteins