Rph3a
entrez
171039
canonical
uniprot
P47709
canonical
ensembl
ENSRNOG00000001368
resolver
ensp
ENSRNOP00000001844
resolver
ensp
ENSRNOP00000103857
resolver
enst
ENSRNOT00000001844
resolver
enst
ENSRNOT00000151514
resolver
genesymbol
Rph3a
resolver
uniprot
A0ABK0L3H9
resolver
uniprot
F1LPB9
resolver
uniprot_entry
A0ABK0L3H9_RAT
resolver
uniprot_entry
F1LPB9_RAT
resolver
uniprot_entry
RP3A_RAT
resolver
amino_acid_sequence
MTDTVVNRWMYPGDGPLQSNDKEQLQAGWSVHPGAQTDRQRKQEELTDEEKEIINRVIARAEKMETMEQERIGRLVDRLETMRKNVAGDGVNRCILCGEQLGMLGSACVVCEDCKKNVCTKCGVETSNNRPHPVWLCKICLEQREVWKRSGAWFFKGFPKQVLPQPMPIKKTKPQQPAGEPATQEQPTPESRHPARAPARGDMEDRRAPGQKPGPDLTSAPGRGSHGPPTRRASEARMSTTTRDSEGWDHGHGGGAGDTSRSPGGEQGLRRANSVQASRPAPASMPSPAPPQPVQPGPPGGSRAAPGPGRFPEQSTEAPPSDPGYPGAVAPAREERTGPTGGFQAAPHTAGPYSQAAPARQPPPAEEEEEEANSYDSDQATTLGALEFSLLYDQDNSNLQCTIIRAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPVWNETLQYHGITEEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKANQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERIGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWHQLQNENHVSSD
uniprot
proteins
function
FUNCTION: Plays an essential role in docking and fusion steps of regulated exocytosis (PubMed:16203731, PubMed:8617225). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (PubMed:8617225). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability (PubMed:26679993). Also plays a role in the exocytosis of arginine vasopressin hormone (PubMed:29367474). {ECO:0000269|PubMed:16203731, ECO:0000269|PubMed:26679993, ECO:0000269|PubMed:29367474, ECO:0000269|PubMed:8617225}.
uniprot
proteins
mass_dalton
75832
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Deubiquitinated by CAND1 to prevent its degradation. {ECO:0000269|PubMed:29367474}.
uniprot
proteins
pubmed
10025402
uniprot
proteins
pubmed
10559882
uniprot
proteins
pubmed
16203731
uniprot
proteins
pubmed
17166855
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24302762
uniprot
proteins
pubmed
26679993
uniprot
proteins
pubmed
28634303
uniprot
proteins
pubmed
29367474
uniprot
proteins
pubmed
7946335
uniprot
proteins
pubmed
8060298
uniprot
proteins
pubmed
8617225
uniprot
proteins
sequence_length
684
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:8060298, ECO:0000269|PubMed:8617225}. Cell projection, dendritic spine {ECO:0000269|PubMed:26679993}. Postsynaptic cell membrane {ECO:0000269|PubMed:26679993}. Membrane {ECO:0000269|PubMed:17166855}; Peripheral membrane protein {ECO:0000269|PubMed:17166855}.
uniprot
proteins