TMPRSS12
entrez
283471
canonical
uniprot
Q86WS5
canonical
ensembl
ENSG00000186452
resolver
ensp
ENSP00000381476
resolver
enst
ENST00000398458
resolver
genesymbol
TMPRSS12
resolver
hgnc
HGNC:28779
resolver
uniprot
A0A140VJY1
resolver
uniprot
B9ZVX2
resolver
uniprot_entry
A0A140VJY1_HUMAN
resolver
uniprot_entry
TMPSC_HUMAN
resolver
uniprot_sec
B9ZVX2
resolver
amino_acid_sequence
MRLGLLSVALLFVGSSHLYSDHYSPSGRHRLGPSPEPAASSQQAEAVRKRLRRRREGGAHAEDCGTAPLKDVLQGSRIIGGTEAQAGAWPWVVSLQIKYGRVLVHVCGGTLVRERWVLTAAHCTKDASDPLMWTAVIGTNNIHGRYPHTKKIKIKAIIIHPNFILESYVNDIALFHLKKAVRYNDYIQPICLPFDVFQILDGNTKCFISGWGRTKEEGNATNILQDAEVHYISREMCNSERSYGGIIPNTSFCAGDEDGAFDTCRGDSGGPLMCYLPEYKRFFVMGITSYGHGCGRRGFPGVYIGPSFYQKWLTEHFFHASTQGILTINILRGQILIALCFVILLATT
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Required for male fertility (By similarity). Plays a critical role in sperm capacitation and acrosome reactions during fertilization, and also plays a role in the regulation of proteins involved in spermatogenesis (By similarity). Regulates protein pathways that promote chromosomal synapsis formation, double-strand break repair, formation of the inner mitochondrial membrane cristae and apoptosis in developing sperm (By similarity). Required for normal sperm motility and binding to the zona pellucida, potentially via a role in ADAM3 protein maturation (By similarity). {ECO:0000250|UniProtKB:Q3V0Q7}.
uniprot
proteins
mass_dalton
38605
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
23436708
uniprot
proteins
pubmed
35547804
uniprot
proteins
sequence_length
348
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23436708}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q3V0Q7}. Note=Expression in the acrosome decreases after acrosome reaction. {ECO:0000250|UniProtKB:Q3V0Q7}.
uniprot
proteins
transmembrane_region
TRANSMEM 325..345; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins