Pmaip1
entrez
58801
canonical
uniprot
Q9JM54
canonical
ensembl
ENSMUSG00000024521
resolver
ensp
ENSMUSP00000025399
resolver
enst
ENSMUST00000025399
resolver
genesymbol
Pmaip1
resolver
genesymbol_syn
Noxa
resolver
uniprot_entry
APR_MOUSE
resolver
amino_acid_sequence
MPGRKARRNAPVNPTRAELPPEFAAQLRKIGDKVYCTWSAPDITVVLAQMPGKSQKSRMRSPSPTRVPADLKDECAQLRRIGDKVNLRQKLLNLISKLFNLVT
uniprot
proteins
function
FUNCTION: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1 (By similarity). Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. {ECO:0000250, ECO:0000269|PubMed:10807576, ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:15901672, ECO:0000269|PubMed:16822983, ECO:0000269|PubMed:17389404}.
uniprot
proteins
mass_dalton
11566
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="L->A: Loss of pro-apoptotic activity and of targeting to mitochondria; when associated with A-78."; /evidence="ECO:0000269|PubMed:10807576"; MUTAGEN 78; /note="L->A: Loss of pro-apoptotic activity and of targeting to mitochondria; when associated with A-27."; /evidence="ECO:0000269|PubMed:10807576
uniprot
proteins
protein_family
PMAIP1 family
uniprot
proteins
pubmed
10807576
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15694340
uniprot
proteins
pubmed
15901672
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16822983
uniprot
proteins
pubmed
17389404
uniprot
proteins
sequence_length
103
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10807576}.
uniprot
proteins