SLC1A3
entrez
6507
canonical
uniprot
P43003
canonical
ensembl
ENSG00000079215
resolver
ensp
ENSP00000265113
resolver
ensp
ENSP00000477672
resolver
ensp
ENSP00000483657
resolver
ensp
ENSP00000505057
resolver
ensp
ENSP00000505850
resolver
ensp
ENSP00000506048
resolver
ensp
ENSP00000506207
resolver
ensp
ENSP00000506424
resolver
ensp
ENSP00000506577
resolver
ensp
ENSP00000506599
resolver
ensp
ENSP00000528365
resolver
ensp
ENSP00000528366
resolver
enst
ENST00000504121
resolver
enst
ENST00000512374
resolver
enst
ENST00000612708
resolver
enst
ENST00000613445
resolver
enst
ENST00000680232
resolver
enst
ENST00000681909
resolver
genesymbol
SLC1A3
resolver
genesymbol_syn
EAAT1
resolver
genesymbol_syn
GLAST
resolver
genesymbol_syn
GLAST1
resolver
hgnc
HGNC:10941
resolver
uniprot
A0A087WT87
resolver
uniprot
A0A087X0U3
resolver
uniprot
A0A7P0TAG7
resolver
uniprot
A0A7P0TBI7
resolver
uniprot
B2R5T3
resolver
uniprot
B4DF14
resolver
uniprot
Q4JCQ8
resolver
uniprot
Q7Z5T0
resolver
uniprot
Q8N169
resolver
uniprot_entry
A0A087WT87_HUMAN
resolver
uniprot_entry
A0A087X0U3_HUMAN
resolver
uniprot_entry
A0A7P0TAG7_HUMAN
resolver
uniprot_entry
A0A7P0TBI7_HUMAN
resolver
uniprot_entry
B4DF14_HUMAN
resolver
uniprot_entry
EAA1_HUMAN
resolver
uniprot_entry
Q7Z5T0_HUMAN
resolver
uniprot_entry
Q8N169_HUMAN
resolver
uniprot_sec
B2R5T3
resolver
uniprot_sec
Q4JCQ8
resolver
amino_acid_sequence
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVGTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPPNLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSETKM
uniprot
proteins
disease_involvement
DISEASE: Episodic ataxia 6 (EA6) [MIM:612656]: A disorder characterized by episodic ataxia, seizures, migraine and alternating hemiplegia. {ECO:0000269|PubMed:16116111}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515, PubMed:7521911, PubMed:8123008). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). {ECO:0000250|UniProtKB:P56564, ECO:0000269|PubMed:20477940, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:28424515, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008}.
uniprot
proteins
mass_dalton
59572
uniprot
proteins
mutagenesis
MUTAGEN 363; /note="S->R: Loss of electrogenic glutamate transport. Strongly decreased L-aspartate and L-glutamate uptake combined with strongly increased permeability ot other ions; when associated with M-477."; /evidence="ECO:0000269|PubMed:20477940"; MUTAGEN 477; /note="R->M: Strongly decreased L-aspartate and L-glutamate uptake combined with strongly increased permeability ot other ions; when associated with R-363."; /evidence="ECO:0000269|PubMed:20477940"; MUTAGEN 523; /note="Y->F: No effect on activity."; /evidence="ECO:0000269|PubMed:28032905
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:P24942}.
uniprot
proteins
protein_family
Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family
uniprot
proteins
protein_family
SLC1A3 subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
16042756
uniprot
proteins
pubmed
16116111
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20477940
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26690923
uniprot
proteins
pubmed
28032905
uniprot
proteins
pubmed
28424515
uniprot
proteins
pubmed
7521911
uniprot
proteins
pubmed
8123008
uniprot
proteins
pubmed
8218410
uniprot
proteins
pubmed
8647279
uniprot
proteins
sequence_length
542
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20477940, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008}; Multi-pass membrane protein {ECO:0000269|PubMed:28424515}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..68; /note="Helical; Name=1"; /evidence="ECO:0000305|PubMed:28424515"; TRANSMEM 87..108; /note="Helical; Name=2"; /evidence="ECO:0000305|PubMed:28424515"; TRANSMEM 123..145; /note="Helical; Name=3"; /evidence="ECO:0000305|PubMed:28424515"; TRANSMEM 237..260; /note="Helical; Name=4"; /evidence="ECO:0000305|PubMed:28424515"; TRANSMEM 270..297; /note="Helical; Name=5"; /evidence="ECO:0000305|PubMed:28424515"; TRANSMEM 319..340; /note="Helical; Name=6"; /evidence="ECO:0000305|PubMed:28424515"; TRANSMEM 386..412; /note="Helical; Name=7"; /evidence="ECO:0000305|PubMed:28424515"; TRANSMEM 473..494; /note="Helical; Name=8"; /evidence="ECO:0000305|PubMed:28424515
uniprot
proteins