ALCAM
entrez
214
canonical
uniprot
Q13740
canonical
ensembl
ENSG00000170017
resolver
ensp
ENSP00000305988
resolver
ensp
ENSP00000419236
resolver
ensp
ENSP00000780669
resolver
ensp
ENSP00000789926
resolver
genesymbol
ALCAM
resolver
genesymbol_syn
MEMD
resolver
hgnc
HGNC:400
resolver
uniprot
B2RNS3
resolver
uniprot
B3KNN9
resolver
uniprot
B4DTU0
resolver
uniprot
O60892
resolver
uniprot
Q1HGM8
resolver
uniprot
Q1HGM9
resolver
uniprot
Q6PEY4
resolver
uniprot
Q6ZS95
resolver
uniprot_entry
B3KNN9_HUMAN
resolver
uniprot_entry
CD166_HUMAN
resolver
uniprot_sec
B2RNS3
resolver
uniprot_sec
B4DTU0
resolver
uniprot_sec
O60892
resolver
uniprot_sec
Q1HGM8
resolver
uniprot_sec
Q1HGM9
resolver
uniprot_sec
Q6PEY4
resolver
uniprot_sec
Q6ZS95
resolver
amino_acid_sequence
MESKGASSCRLLFCLLISATVFRPGLGWYTVNSAYGDTIIIPCRLDVPQNLMFGKWKYEKPDGSPVFIAFRSSTKKSVQYDDVPEYKDRLNLSENYTLSISNARISDEKRFVCMLVTEDNVFEAPTIVKVFKQPSKPEIVSKALFLETEQLKKLGDCISEDSYPDGNITWYRNGKVLHPLEGAVVIIFKKEMDPVTQLYTMTSTLEYKTTKADIQMPFTCSVTYYGPSGQKTIHSEQAVFDIYYPTEQVTIQVLPPKNAIKEGDNITLKCLGNGNPPPEEFLFYLPGQPEGIRSSNTYTLTDVRRNATGDYKCSLIDKKSMIASTAITVHYLDLSLNPSGEVTRQIGDALPVSCTISASRNATVVWMKDNIRLRSSPSFSSLHYQDAGNYVCETALQEVEGLKKRESLTLIVEGKPQIKMTKKTDPSGLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSKIIISPEENVTLTCTAENQLERTVNSLNVSAISIPEHDEADEISDENREKVNDQAKLIVGIVVGLLLAALVAGVVYWLYMKKSKTASKHVNKDLGNMEENKKLEENNHKTEA
uniprot
proteins
function
FUNCTION: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:15048703, PubMed:15496415, PubMed:16352806, PubMed:23169771, PubMed:24945728, PubMed:7760007). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation (PubMed:29263213). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). {ECO:0000250|UniProtKB:P42292, ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:15496415, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:29263213, ECO:0000269|PubMed:7760007}.; FUNCTION: [Isoform 3]: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation. {ECO:0000269|PubMed:15496415}.
uniprot
proteins
mass_dalton
65102
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:15496415, ECO:0000305|PubMed:24945728}.
uniprot
proteins
pubmed
12754519
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15048703
uniprot
proteins
pubmed
15294938
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15496415
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16352806
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16914752
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23169771
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24740813
uniprot
proteins
pubmed
24945728
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26146185
uniprot
proteins
pubmed
29263213
uniprot
proteins
pubmed
7760007
uniprot
proteins
pubmed
8520490
uniprot
proteins
pubmed
8823162
uniprot
proteins
pubmed
9502422
uniprot
proteins
sequence_length
583
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:23169771, ECO:0000269|PubMed:24740813, ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:7760007}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q61490}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q61490}. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse (PubMed:15294938). {ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:15496415}.
uniprot
proteins
transmembrane_region
TRANSMEM 528..549; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins