EIF1
entrez
10209
canonical
uniprot
P41567
canonical
ensembl
ENSG00000173812
resolver
ensp
ENSP00000419449
resolver
enst
ENST00000469257
resolver
genesymbol
EIF1
resolver
genesymbol
SUI1
resolver
genesymbol_syn
EIF1
resolver
genesymbol_syn
SUI1
resolver
hgnc
HGNC:3249
resolver
uniprot
Q6IAV3
resolver
uniprot
Q9UNQ9
resolver
uniprot_entry
EIF1_HUMAN
resolver
uniprot_entry
Q6IAV3_HUMAN
resolver
uniprot_sec
Q9UNQ9
resolver
amino_acid_sequence
MSAIQNLHSFDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVIQLQGDQRKNICQFLVEIGLAKDDQLKVHGF
uniprot
proteins
function
FUNCTION: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:12435632, PubMed:14600024, PubMed:9732867). Together with eIF1A (EIF1AX), EIF1 facilitates scanning and is essential for start codon recognition on the basis of AUG nucleotide context and location relative to the 5'-cap (PubMed:12435632, PubMed:14600024, PubMed:9732867). Participates to initiation codon selection by influencing the conformation of the 40S ribosomal subunit and the positions of bound mRNA and initiator tRNA; this is possible after its binding to the interface surface of the platform of the 40S ribosomal subunit close to the P-site (PubMed:14600024). Together with eIF1A (EIF1AX), also regulates the opening and closing of the mRNA binding channel, which ensures mRNA recruitment, scanning and the fidelity of initiation codon selection (PubMed:9732867). Continuously monitors and protects against premature and partial base-pairing of codons in the 5'-UTR with the anticodon of initiator tRNA (PubMed:12435632, PubMed:9732867). Together with eIF1A (EIF1AX), acts for ribosomal scanning, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes (PubMed:9732867). Interacts with EIF4G1, which in a mutual exclusive interaction associates either with EIF1 or with EIF4E on a common binding site (PubMed:29987188). EIF4G1-EIF1 complex promotes ribosome scanning (on both short and long 5'UTR), leaky scanning (on short 5'UTR) which is the bypass of the initial start codon, and discrimination against cap-proximal AUG (PubMed:29987188). Is probably maintained within the 43S PIC in open conformation thanks to eIF1A-EIF5 interaction (PubMed:24319994). Once the correct start codon is reached, EIF1 is physically excluded from the decoding site, shifting the PIC into the closed conformation and arresting it at the start codon (PubMed:22813744). {ECO:0000269|PubMed:12435632, ECO:0000269|PubMed:14600024, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:29987188, ECO:0000269|PubMed:9732867}.
uniprot
proteins
mass_dalton
12732
uniprot
proteins
mutagenesis
MUTAGEN 57..58; /note="KK->AA: Decrease in interaction with EIF4G1."; /evidence="ECO:0000269|PubMed:29987188"; MUTAGEN 109..111; /note="KVH->AVA: Decrease in interaction with EIF4G1."; /evidence="ECO:0000269|PubMed:29987188
uniprot
proteins
protein_family
SUI1 family
uniprot
proteins
pubmed
10228174
uniprot
proteins
pubmed
10347211
uniprot
proteins
pubmed
11073994
uniprot
proteins
pubmed
12435632
uniprot
proteins
pubmed
14600024
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22813744
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24319994
uniprot
proteins
pubmed
29987188
uniprot
proteins
pubmed
7904817
uniprot
proteins
pubmed
9732867
uniprot
proteins
sequence_length
113
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins