ACVR2A
entrez
92
canonical
uniprot
P27037
canonical
ensembl
ENSG00000121989
resolver
ensp
ENSP00000241416
resolver
ensp
ENSP00000384338
resolver
ensp
ENSP00000439988
resolver
genesymbol
ACVR2A
resolver
genesymbol_syn
ACVR2
resolver
hgnc
HGNC:173
resolver
uniprot
B2RAB8
resolver
uniprot
B4DWQ2
resolver
uniprot
D3DP85
resolver
uniprot
Q53TH4
resolver
uniprot
Q6NWV2
resolver
uniprot
Q92474
resolver
uniprot_entry
AVR2A_HUMAN
resolver
uniprot_sec
B2RAB8
resolver
uniprot_sec
B4DWQ2
resolver
uniprot_sec
D3DP85
resolver
uniprot_sec
Q53TH4
resolver
uniprot_sec
Q6NWV2
resolver
uniprot_sec
Q92474
resolver
amino_acid_sequence
MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
uniprot
proteins
ec_number
2.7.11.30
uniprot
proteins
function
FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A (PubMed:17911401, PubMed:10652306). Mediates induction of adipogenesis by GDF6 (By similarity). {ECO:0000250|UniProtKB:P27038, ECO:0000269|PubMed:1314589, ECO:0000269|PubMed:17911401}.
uniprot
proteins
mass_dalton
57848
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TGFB receptor subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
10652306
uniprot
proteins
pubmed
12667445
uniprot
proteins
pubmed
1311955
uniprot
proteins
pubmed
1314589
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17911401
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
21791611
uniprot
proteins
pubmed
25368322
uniprot
proteins
sequence_length
513
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P27038}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 136..161; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins