Sacm1l
entrez
83493
canonical
uniprot
Q9EP69
canonical
ensembl
ENSMUSG00000025240
resolver
ensp
ENSMUSP00000026270
resolver
ensp
ENSMUSP00000158880
resolver
ensp
ENSMUSP00000159019
resolver
enst
ENSMUST00000026270
resolver
enst
ENSMUST00000238984
resolver
enst
ENSMUST00000239083
resolver
genesymbol
Sacm1l
resolver
genesymbol_syn
Kiaa0851
resolver
genesymbol_syn
Sac1
resolver
uniprot
A0A5F8MPK9
resolver
uniprot
Q80TQ1
resolver
uniprot
Q99K33
resolver
uniprot_entry
A0A5F8MPK9_MOUSE
resolver
uniprot_entry
SAC1_MOUSE
resolver
uniprot_sec
Q80TQ1
resolver
uniprot_sec
Q99K33
resolver
amino_acid_sequence
MAAAAYEHLKLHITPEKFYVEACDDGADDVLIIDRVSTEVTLAVKKDVPPSAVTRPIFGILGTIHLVAGNYLVVITKKMKVGECFNHAVWRATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLSMDGFYFSTTYDLTHTLQRLSNTSPEFQEMSLLERADQRFVWNGHLLRELSAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYSGNRASFVQTRGSIPIFWSQRPNLKYKPHPQISKVANHMDGFQRHFDSQVIIYGKQVIINLVNHKGSEKPLEQTFANMVSSLGSGMIRYIAFDFHKECKNMRWDRLSILLDQVAEMQDELSYFLVDSAGKVVTNQDGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQDEFEKTYKNAWADNANACAKQYAGTGALKTDFTRTGKRTQLGLLMDGFNSLLRYYKNNFSDGFRQDSIDLFLGNYSVDELESHSPLSVPRDWKFLALPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWGVASIGTFFIILYNGKDFVDAPRLVQKEKID
uniprot
proteins
ec_number
3.1.3.64
uniprot
proteins
function
FUNCTION: Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:32931550). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (By similarity). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (By similarity). {ECO:0000250|UniProtKB:Q9ES21, ECO:0000250|UniProtKB:Q9NTJ5, ECO:0000269|PubMed:32931550}.
uniprot
proteins
mass_dalton
66944
uniprot
proteins
pubmed
11352561
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32931550
uniprot
proteins
sequence_length
587
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ES21}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9NTJ5}; Multi-pass membrane protein {ECO:0000255}. Note=Trafficking between the ER and Golgi is regulated by nutrient status and by TMEM39A. Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) in the presence of phosphatidylinositol-4,5-bisphosphate. {ECO:0000250|UniProtKB:Q9NTJ5}.
uniprot
proteins
transmembrane_region
TRANSMEM 521..541; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 549..569; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins