Txn
entrez
22166
canonical
uniprot
P10639
canonical
ensembl
ENSMUSG00000028367
resolver
ensp
ENSMUSP00000030051
resolver
enst
ENSMUST00000030051
resolver
genesymbol
Txn
resolver
genesymbol_syn
Txn1
resolver
uniprot
Q52KC4
resolver
uniprot
Q9D8R0
resolver
uniprot_entry
THIO_MOUSE
resolver
uniprot_sec
Q52KC4
resolver
uniprot_sec
Q9D8R0
resolver
amino_acid_sequence
MVKLIESKEAFQEALAAAGDKLVVVDFSATWCGPCKMIKPFFHSLCDKYSNVVFLEVDVDDCQDVAADCEVKCMPTFQFYKKGQKVGEFSGANKEKLEASITEYA
uniprot
proteins
function
FUNCTION: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity). {ECO:0000250}.; FUNCTION: ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
uniprot
proteins
mass_dalton
11675
uniprot
proteins
post_translational_modification
PTM: In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Thioredoxin family
uniprot
proteins
pubmed
10843682
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
2785919
uniprot
proteins
pubmed
7835695
uniprot
proteins
pubmed
8187776
uniprot
proteins
sequence_length
105
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P10599}. Cytoplasm {ECO:0000250|UniProtKB:P10599}. Secreted {ECO:0000250|UniProtKB:P10599}. Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA). Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus. Secreted by a leaderless secretory pathway. {ECO:0000250|UniProtKB:P10599}.
uniprot
proteins