KYAT3
entrez
56267
canonical
uniprot
Q6YP21
canonical
ensembl
ENSG00000137944
resolver
ensp
ENSP00000260508
resolver
ensp
ENSP00000359522
resolver
ensp
ENSP00000727178
resolver
genesymbol
KYAT3
resolver
genesymbol_syn
CCBL2
resolver
genesymbol_syn
KAT3
resolver
hgnc
HGNC:33238
resolver
uniprot
B3KQ13
resolver
uniprot
O95335
resolver
uniprot
Q5JS27
resolver
uniprot
Q5T9T7
resolver
uniprot
Q5T9T8
resolver
uniprot
Q6AI27
resolver
uniprot
Q6ICW1
resolver
uniprot
Q9BVY5
resolver
uniprot_entry
KAT3_HUMAN
resolver
uniprot_sec
B3KQ13
resolver
uniprot_sec
O95335
resolver
uniprot_sec
Q5JS27
resolver
uniprot_sec
Q5T9T7
resolver
uniprot_sec
Q5T9T8
resolver
uniprot_sec
Q6AI27
resolver
uniprot_sec
Q6ICW1
resolver
uniprot_sec
Q9BVY5
resolver
amino_acid_sequence
MFLAQRSLCSLSGRAKFLKTISSSKILGFSTSAKMSLKFTNAKRIEGLDSNVWIEFTKLAADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKPVYGKRWSSSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAFWIDIKRMDDPECYFNSLPKELEVKRDRMVRLLESVGLKPIVPDGGYFIIADVSLLDPDLSDMKNNEPYDYKFVKWMTKHKKLSAIPVSAFCNSETKSQFEKFVRFCFIKKDSTLDAAEEIIKAWSVQKS
uniprot
proteins
ec_number
2.6.1.63
uniprot
proteins
ec_number
2.6.1.7
uniprot
proteins
ec_number
4.4.1.13
uniprot
proteins
function
FUNCTION: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro). {ECO:0000250|UniProtKB:Q71RI9}.
uniprot
proteins
mass_dalton
51400
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2. {ECO:0000250|UniProtKB:Q71RI9}.
uniprot
proteins
protein_family
Class-I pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16376499
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
sequence_length
454
uniprot
proteins