RCC2
entrez
55920
canonical
uniprot
Q9P258
canonical
ensembl
ENSG00000179051
resolver
ensembl
ENSG00000281540
resolver
ensp
ENSP00000364582
resolver
ensp
ENSP00000364585
resolver
ensp
ENSP00000486099
resolver
ensp
ENSP00000486447
resolver
ensp
ENSP00000597143
resolver
ensp
ENSP00000597152
resolver
enst
ENST00000375433
resolver
enst
ENST00000375436
resolver
enst
ENST00000628984
resolver
enst
ENST00000631021
resolver
enst
ENST00000927084
resolver
enst
ENST00000927093
resolver
genesymbol
RCC2
resolver
genesymbol_syn
KIAA1470
resolver
genesymbol_syn
TD60
resolver
hgnc
HGNC:30297
resolver
uniprot
A0A024RAC5
resolver
uniprot
A0A384NYY6
resolver
uniprot
Q8IVL9
resolver
uniprot
Q9BSN6
resolver
uniprot
Q9NPV8
resolver
uniprot_entry
A0A024RAC5_HUMAN
resolver
uniprot_entry
RCC2_HUMAN
resolver
uniprot_sec
A0A384NYY6
resolver
uniprot_sec
Q8IVL9
resolver
uniprot_sec
Q9BSN6
resolver
uniprot_sec
Q9NPV8
resolver
amino_acid_sequence
MPRKKAAAAAWEEPSSGNGTARAGPRKRGGPAGRKRERPERCSSSSGGGSSGDEDGLELDGAPGGGKRAARPATAGKAGGAAVVITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESETEKEKIKKLPEYNPRTL
uniprot
proteins
function
FUNCTION: Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA (PubMed:12919680, PubMed:25074804, PubMed:26158537, PubMed:28869598). Required for normal progress through the cell cycle, both during interphase and during mitosis (PubMed:12919680, PubMed:23388455, PubMed:26158537). Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles (PubMed:12919680, PubMed:26158537). Required for normal organization of the microtubule cytoskeleton in interphase cells (PubMed:23388455). Functions as guanine nucleotide exchange factor (GEF) for RALA (PubMed:26158537). Interferes with the activation of RAC1 by guanine nucleotide exchange factors (PubMed:25074804). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804, PubMed:28869598). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (PubMed:25074804, PubMed:28869598). {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:23388455, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:26158537, ECO:0000269|PubMed:28869598}.
uniprot
proteins
mass_dalton
56085
uniprot
proteins
mutagenesis
MUTAGEN 318..325; /note="Missing: Loss of interaction with RAC1."; /evidence="ECO:0000269|PubMed:28869598"; MUTAGEN 439; /note="K->E: Loss of interaction with RAC1 and loss of regulation of RAC1 activation."; /evidence="ECO:0000269|PubMed:25074804
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
12919680
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
1939370
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23388455
uniprot
proteins
pubmed
25074804
uniprot
proteins
pubmed
26158537
uniprot
proteins
pubmed
28869598
uniprot
proteins
pubmed
7559776
uniprot
proteins
pubmed
9914378
uniprot
proteins
sequence_length
522
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000305|PubMed:12429849}. Nucleus {ECO:0000269|PubMed:23388455}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23388455}. Chromosome, centromere {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:9914378}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:9914378}. Chromosome {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:9914378}. Midbody {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:9914378}. Cell membrane {ECO:0000269|PubMed:25074804}; Peripheral membrane protein {ECO:0000305|PubMed:25074804}; Cytoplasmic side {ECO:0000305|PubMed:25074804}. Note=Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex (PubMed:12919680, PubMed:1939370, PubMed:7559776, PubMed:9914378). Colocalizes with cytoplasmic microtubules in interphase cells (PubMed:23388455). Colocalizes with RAC1 at the cell membrane (PubMed:25074804). {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:23388455, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:7559776, ECO:0000269|PubMed:9914378}.
uniprot
proteins