Tbc1d7
entrez
67046
canonical
uniprot
Q9D0K0
canonical
ensembl
ENSMUSG00000021368
resolver
ensp
ENSMUSP00000021797
resolver
ensp
ENSMUSP00000137280
resolver
ensp
ENSMUSP00000152358
resolver
ensp
ENSMUSP00000318782
resolver
genesymbol
Tbc1d7
resolver
uniprot
B7ZNC1
resolver
uniprot
Q05AE0
resolver
uniprot
Q3U0V0
resolver
uniprot_entry
TBCD7_MOUSE
resolver
uniprot_sec
B7ZNC1
resolver
uniprot_sec
Q05AE0
resolver
uniprot_sec
Q3U0V0
resolver
amino_acid_sequence
MTDDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCTFSQRFPLPSMYRALVWKALLGILPPHHDTHSQVMAYRKDQYHDILHALTVVRFISDATPQAEVYLRMYQLESGKLPRSPSFPLEPEDEVFLAIAKAMEEMVEDSVDCYWISRCFVKQLNNKYRDALPQLPKAFEQYLNLEDSRLLSHLKTCSAVSKLPYDLWFQRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSA
uniprot
proteins
function
FUNCTION: Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:22795129). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (By similarity). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (By similarity). {ECO:0000250|UniProtKB:Q9P0N9, ECO:0000269|PubMed:22795129}.
uniprot
proteins
mass_dalton
33826
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22795129
uniprot
proteins
sequence_length
293
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9P0N9}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9P0N9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9P0N9}. Note=Localizes in the cytoplasmic vesicles of the endomembrane in association with the TSC-TBC complex. Recruited to lysosomal membranes in a RHEB-dependent process in absence of nutrients. In response to nutrients, the complex dissociates from lysosomal membranes and relocalizes to the cytosol. {ECO:0000250|UniProtKB:Q9P0N9}.
uniprot
proteins