Havcr1
entrez
286934
canonical
uniprot
O54947
canonical
ensembl
ENSRNOG00000007243
resolver
ensembl
ENSRNOG00065005775
resolver
ensp
ENSRNOP00000009573
resolver
ensp
ENSRNOP00065006100
resolver
enst
ENSRNOT00000009573
resolver
enst
ENSRNOT00065008637
resolver
genesymbol
Havcr1
resolver
genesymbol_syn
Kim1
resolver
uniprot
G3V6W3
resolver
uniprot_entry
G3V6W3_RAT
resolver
uniprot_entry
HAVR1_RAT
resolver
amino_acid_sequence
MVQLQVFISGLLLLLPGSVDSYEVVKGVVGHPVTIPCTYSTRGGITTTCWGRGQCPYSSCQNILIWTNGYQVTYRSSGRYNIKGRISEGDVSLTIENSVDSDSGLYCCRVEIPGWFNDQKMTFSLEVKPEIPTSPPTRPTTTRPTTTRPTTISTRSTHVPTSTRVSTSTPTPEQTQTHKPEITTFYAHETTAEVTETPSYTPADWNGTVTSSEEAWNNHTVRIPLRKPQRNPTKGFYVGMSVAALLLLLLASTVVVTRYIIIRKKMGSLSFVAFHVSKSRALQNAAIVHPRAEDNIYIIEDRSRGAE
uniprot
proteins
function
FUNCTION: Phosphatidylserine receptor that plays an important functional role in regulatory B-cell homeostasis including generation, expansion and suppressor functions (By similarity). Involved in efferocytosis, the process by which apoptotic cells are removed, by binding to phosphatidylserine present on apoptotic cells and promoting their engulfment (By similarity). Confers phagocytic ability on injured kidney epithelial cells, allowing them to bind to and internalize apoptotic bodies and necrotic debris following kidney injury (PubMed:18414680). The ectodomain binds to the surface of apoptotic kidney epithelial cells via phosphatidylserine and oxidized phospholipids exposed on the cell membrane of the apoptotic cells (By similarity). HAVCR1-expressing cells are also capable of phagocytosing Gram-negative and Gram-positive bacteria (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (By similarity). Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (By similarity). Acts as a regulator of T-cell proliferation. Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity). {ECO:0000250|UniProtKB:Q5QNS5, ECO:0000250|UniProtKB:Q96D42, ECO:0000269|PubMed:18414680}.
uniprot
proteins
mass_dalton
33964
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
TIM family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18414680
uniprot
proteins
pubmed
9461608
uniprot
proteins
sequence_length
307
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96D42}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q96D42}. Cell projection, phagocytic cup {ECO:0000269|PubMed:18414680}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q96D42}.
uniprot
proteins
transmembrane_region
TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins