Ehd3
entrez
57440
canonical
uniprot
Q9QXY6
canonical
ensembl
ENSMUSG00000024065
resolver
ensp
ENSMUSP00000024860
resolver
enst
ENSMUST00000024860
resolver
genesymbol
Ehd3
resolver
genesymbol_syn
Ehd2
resolver
uniprot
Q8K590
resolver
uniprot_entry
EHD3_MOUSE
resolver
uniprot_sec
Q8K590
resolver
amino_acid_sequence
MFSWLGNDDRRKKDPEVFQTVSDGLKKLYKTKLLPLEEYYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMQGDVEGIIPGNALVVDPKKPFRKLNAFGNAFLNRFVCAQLPNAVLESISVIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVYGALMWSLGKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPSVFGKDTKKKELVNNLAEIYGRIEREHQISPGDFPNLKRMQDQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEETQRPVQMVKGGAFEGTLQGPFGHGYGEGAGEGIDDAEWVVARDKPMYDEIFYTLSPVDGKITGANAKKEMVRSKLPNSVLGKIWKLADIDKDGMLDDEEFALANHLIKVKLEGHELPSELPAHLLPPSKRKVSE
uniprot
proteins
function
FUNCTION: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes tubulation of endocytic membranes (By similarity). Binding to phosphatidic acid induces its membrane tubulation activity (PubMed:26896729). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (By similarity). Involved in the recycling of internalized D1 dopamine receptor (By similarity). Plays a role in cardiac protein trafficking probably implicating ANK2. Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (PubMed:20489164, PubMed:24759929, PubMed:25825486). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (PubMed:21408024). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with Ehd1 (PubMed:25686250). {ECO:0000250|UniProtKB:Q9NZN3, ECO:0000269|PubMed:20489164, ECO:0000269|PubMed:21408024, ECO:0000269|PubMed:24373286, ECO:0000269|PubMed:24759929, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25825486, ECO:0000269|PubMed:26896729}.
uniprot
proteins
mass_dalton
60821
uniprot
proteins
mutagenesis
MUTAGEN 327; /note="K->D: Loss of localization to membranes, reduced binding to phosphatidic acid."; /evidence="ECO:0000269|PubMed:26896729
uniprot
proteins
protein_family
Dynamin/Fzo/YdjA family
uniprot
proteins
protein_family
EHD subfamily
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
12121420
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15930129
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17251388
uniprot
proteins
pubmed
17507647
uniprot
proteins
pubmed
20489164
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21408024
uniprot
proteins
pubmed
22974368
uniprot
proteins
pubmed
24373286
uniprot
proteins
pubmed
24759929
uniprot
proteins
pubmed
25686250
uniprot
proteins
pubmed
25825486
uniprot
proteins
pubmed
26896729
uniprot
proteins
sequence_length
535
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:Q9NZN3, ECO:0000305|PubMed:12121420}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q9NZN3}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q9NZN3}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:12121420, ECO:0000269|PubMed:24373286}. Note=Localizes to the ciliary pocket from where the cilium protrudes (By similarity). Colocalizes with RAB8A and MYO5B to a cytoplasmic tubular network devoid of RAB11A (PubMed:17507647). Colocalizes with ANK2 in myocyte perinuclear region (PubMed:25825486). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippocampal mossy fiber terminals (PubMed:24373286). {ECO:0000250|UniProtKB:Q9NZN3, ECO:0000269|PubMed:17507647, ECO:0000269|PubMed:24373286, ECO:0000269|PubMed:25825486}.
uniprot
proteins