Trib3
entrez
228775
canonical
uniprot
Q8K4K2
canonical
ensembl
ENSMUSG00000032715
resolver
ensp
ENSMUSP00000041747
resolver
enst
ENSMUST00000040312
resolver
genesymbol
Trib3
resolver
genesymbol_syn
Nipk
resolver
genesymbol_syn
Trb3
resolver
uniprot
Q3UMQ0
resolver
uniprot
Q921E7
resolver
uniprot_entry
TRIB3_MOUSE
resolver
uniprot_sec
Q3UMQ0
resolver
uniprot_sec
Q921E7
resolver
amino_acid_sequence
MRATPLAASADVSCRKKPLEFDDNIDAKCPVLKRVRDEPEPGPLPSLLPPSPPPASDLSPAVAPATRLGPYILLEREQGSCSYRALHCPTGTEYTCKVYPASEAQAVLAPYARLPTHQHVARPTEVLLGSRLLYIFFTKTHGDLHSLVRSRRGIPESEAAGLFRQMASAVAHCHKHGLVLRDLKLRRFVFSNCERTKLVLENLEDACVMTGSDDSLWDKHACPAYVGPEILSSRPSYSGKAADVWSLGVALFTMLAGRYPFHDSEPVLLFGKIRRGTFALPEGLSAPARCLIRCLLRKEPSERLVALGILLHPWLREDHGRVSPPQSDRREMDQVVPDGPQLEEAEEGEVGLYG
uniprot
proteins
function
FUNCTION: Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (PubMed:17369260). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (By similarity). May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (By similarity). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (PubMed:12749859, PubMed:17369260). Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (PubMed:12791994). May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (PubMed:12791994). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases (By similarity). Can inhibit APOBEC3A editing of nuclear DNA (PubMed:22977230). {ECO:0000250|UniProtKB:Q96RU7, ECO:0000269|PubMed:12749859, ECO:0000269|PubMed:12791994, ECO:0000269|PubMed:17369260, ECO:0000269|PubMed:22977230}.
uniprot
proteins
mass_dalton
39023
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tribbles subfamily
uniprot
proteins
pubmed
12749859
uniprot
proteins
pubmed
12791994
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17369260
uniprot
proteins
pubmed
22977230
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12749859, ECO:0000269|PubMed:22977230}.
uniprot
proteins