Blm
entrez
12144
canonical
uniprot
O88700
canonical
ensembl
ENSMUSG00000030528
resolver
ensp
ENSMUSP00000080062
resolver
ensp
ENSMUSP00000127995
resolver
ensp
ENSMUSP00000175366
resolver
enst
ENSMUST00000081314
resolver
enst
ENSMUST00000170315
resolver
genesymbol
Blm
resolver
uniprot
E9PZ97
resolver
uniprot
O88198
resolver
uniprot_entry
BLM_MOUSE
resolver
uniprot_entry
E9PZ97_MOUSE
resolver
uniprot_sec
O88198
resolver
amino_acid_sequence
MAAVPLNNLQEQLQRHSARKLNNQPSLSKPKSLGFTFKKKTSEGDVSVTSVSVVKTPALSDKDVNVSEAFSFTESPLHKPKQQAKIEGFFKHFPGRQQSKGTCSEPSLPATVQTAQDTLCTTPKTPTAKKLPVAVFKKLEFSSSADSLSDWADMDDFDMSASDAFASLAKNPATRVSTAQKMKKTKRNFFKPPPRKANAVKTDLTPPSPECLQVDLTKESEEEEEEEEEAEGADCLSRDVICIDNDSASEELTEKDTQESQSLKAHLGAERGDSEKKSHEDEAVFHSVQNTEYFEHNDNDYDIDFVPPSPEEIISTASSSLKCSSMLKDLDDSDKEKGILSTSEELLSKPEEMTTHKSDAGTSKDCDAQQIRIQQQLIHVMEHICKLVDTVPTDELEALNCGTELLQQRNIRRKLLAEAGFNGNDVRLLGSLWRHRPDSLDNTVQGDSCPVGHPNKELNSPYLLSHSPSTEECLPTTTPGKTGFSATPKNLFERPLLNSHLQKSFVSSNWAETPRMENRNESTDFPGSVLTSTTVKAQSKQAASGWNVERHGQASYDIDNFNIDDFDDDDDDDDWENIMHNFPASKSSTATYPPIKEGGPVKSLSERISSAKAKFLPVVSTAQNTNLSESIQNCSDKLAQNLSSKNPKHEHFQSLNFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTSFDIPATYLTGDKTDSEAANIYLQLSKKDPIIKLLYVTPEKVCASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECDTMADTLQREGLAALAYHAGLSDSARDEVQHKWINQDNCQVICATIAFGMGIDKPDVRFVIHASLPKSMEGYYQESGRAGRDGEISHCVLFYTYHDVTRLKRLIMMEKDGNYHTKETHVNNLYSMVHYCENITECRRIQLLAYFGEKGFNPDFCKKYPDVSCDNCCKTKDYKTKDVTDDVKNIIRFVQEHSSSPGTRNIGPAGRFTLNMLVDIFLGSKSAKVKSGIFGKGTTYSRHNAERLFKKLILDKILDEDLYINANDQPIAYVMLGTKAHSVLSGHLKVDFMETENSSSIKKQKALVAKVSQREEVVKKCLGELTEVCKLLGKVFGVHYFNIFNTATLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVIPVLQKYSEWTVPAEDGSPGARGAPEDTEEEEEEAPVSSHYFANQTRNERKRKKMSATHKPKRRRTSYGGFRAKGGSTTCRKTTSKSKFYGVTGSRSASCASQATSSASRKLGIMAPPKPVNRTFLRPSYAFS
uniprot
proteins
ec_number
5.6.2.4
uniprot
proteins
function
FUNCTION: ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:9840919). Participates in DNA replication and repair (By similarity). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:9840919). Negatively regulates sister chromatid exchange (SCE) (PubMed:27010503, PubMed:9840919). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Unwinds G-quadruplex DNA. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (By similarity). Recruited by the KHDC3-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks. {ECO:0000250|UniProtKB:P54132, ECO:0000269|PubMed:27010503, ECO:0000269|PubMed:29125140, ECO:0000269|PubMed:9840919}.
uniprot
proteins
mass_dalton
158366
uniprot
proteins
mutagenesis
MUTAGEN 264; /note="K->R: Reduces TRIM25-mediated ubiquitination in response to DNA damage. Reduces recruitment of BLM to replication forks and impairs the restart of stalled replication forks."; /evidence="ECO:0000269|PubMed:29125140"; MUTAGEN 680; /note="Q->P: Reduced ATPase and helicase activities."; /evidence="ECO:0000269|PubMed:9840919"; MUTAGEN 703; /note="K->A: Reduced ATPase and helicase activities."; /evidence="ECO:0000269|PubMed:9840919"; MUTAGEN 849; /note="I->T: Reduced ATPase and helicase activities."; /evidence="ECO:0000269|PubMed:9840919"; MUTAGEN 1063; /note="C->S: Reduced ATPase and helicase activities."; /evidence="ECO:0000269|PubMed:9840919
uniprot
proteins
post_translational_modification
PTM: Poly-ubiquitinated by TRIM25 at Lys-264. Deubiquitinated by USP37; leading to stabilization in order to sustain the DNA damage response (By similarity). {ECO:0000250|UniProtKB:P54132, ECO:0000269|PubMed:29125140}.; PTM: Phosphorylated in response to DNA damage. Phosphorylation requires the FANCA-FANCC-FANCE-FANCF-FANCG protein complex, as well as the presence of RMI1 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Helicase family
uniprot
proteins
protein_family
RecQ subfamily
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27010503
uniprot
proteins
pubmed
29125140
uniprot
proteins
pubmed
9655940
uniprot
proteins
pubmed
9840919
uniprot
proteins
sequence_length
1416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29125140}. Note=Localized to DNA replication forks, especially after DNA damage. {ECO:0000269|PubMed:29125140}.
uniprot
proteins