PIP4K2C
entrez
79837
canonical
uniprot
Q8TBX8
canonical
ensembl
ENSG00000166908
resolver
ensp
ENSP00000347032
resolver
ensp
ENSP00000412035
resolver
ensp
ENSP00000439878
resolver
ensp
ENSP00000447390
resolver
ensp
ENSP00000658603
resolver
genesymbol
PIP4K2C
resolver
genesymbol_syn
PIP5K2C
resolver
hgnc
HGNC:23786
resolver
uniprot
B2RDL3
resolver
uniprot
B3KQV3
resolver
uniprot
B4DM11
resolver
uniprot
B4DY44
resolver
uniprot
E7ERY6
resolver
uniprot
Q9H6N2
resolver
uniprot_entry
B3KQV3_HUMAN
resolver
uniprot_entry
PI42C_HUMAN
resolver
uniprot_sec
B2RDL3
resolver
uniprot_sec
B4DM11
resolver
uniprot_sec
B4DY44
resolver
uniprot_sec
E7ERY6
resolver
uniprot_sec
Q9H6N2
resolver
amino_acid_sequence
MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIFA
uniprot
proteins
ec_number
2.7.1.149
uniprot
proteins
function
FUNCTION: Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:31091439}.
uniprot
proteins
mass_dalton
47300
uniprot
proteins
mutagenesis
MUTAGEN 69..75; /note="VMLLPDD->EIFLPNN: Loss of interaction with PIP5K1A. Loss of inhibition of PIP5K1A activity."; /evidence="ECO:0000269|PubMed:31091439
uniprot
proteins
post_translational_modification
PTM: Phosphorylated, phosphorylation is induced by EGF. {ECO:0000250|UniProtKB:O88370}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
26774281
uniprot
proteins
pubmed
31091439
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:O88370}. Cytoplasm {ECO:0000250|UniProtKB:O88370}.
uniprot
proteins