Kif5b
entrez
16573
canonical
uniprot
Q61768
canonical
ensembl
ENSMUSG00000006740
resolver
ensp
ENSMUSP00000025083
resolver
enst
ENSMUST00000025083
resolver
genesymbol
Kif5b
resolver
genesymbol_syn
Khcs
resolver
genesymbol_syn
Kns1
resolver
uniprot
O08711
resolver
uniprot
Q5BL10
resolver
uniprot
Q61580
resolver
uniprot
Q9CUT6
resolver
uniprot_entry
KINH_MOUSE
resolver
uniprot_entry
Q9CUT6_MOUSE
resolver
uniprot_sec
O08711
resolver
uniprot_sec
Q5BL10
resolver
uniprot_sec
Q61580
resolver
amino_acid_sequence
MADPAECNIKVMCRFRPLNESEVNRGDKYVAKFQGEDTVMIASKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKTLRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTADKDIAITSDKPAAAVGMAGSFTDAERRKCEEELAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDSLGEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKEKLITDLQDQNQKMVLEQERLRVEHERLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEVDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPGTVRGGGSFVQNNQPVGLRGGGGKQS
uniprot
proteins
function
FUNCTION: Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. May be involved in the mechanisms of growth arrest induced by exposure to DNA-damaging drugs or by cellular senescence (PubMed:9657148). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (PubMed:21976701). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends. Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity). {ECO:0000250|UniProtKB:P33176, ECO:0000250|UniProtKB:Q2PQA9, ECO:0000269|PubMed:21976701, ECO:0000269|PubMed:9657148}.
uniprot
proteins
mass_dalton
109551
uniprot
proteins
protein_family
Kinesin family
uniprot
proteins
protein_family
Kinesin subfamily
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
11986669
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17532644
uniprot
proteins
pubmed
19886865
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21976701
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
8170981
uniprot
proteins
pubmed
9112396
uniprot
proteins
pubmed
9657148
uniprot
proteins
sequence_length
963
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q2PQA9}. Cytolytic granule membrane {ECO:0000250|UniProtKB:P33176}. Lysosome membrane {ECO:0000250|UniProtKB:P33176}; Peripheral membrane protein {ECO:0000250|UniProtKB:P33176}; Cytoplasmic side {ECO:0000250|UniProtKB:P33176}. Note=Uniformly distributed between soma and neurites in hippocampal neurons. {ECO:0000250|UniProtKB:Q2PQA9}.
uniprot
proteins