KCNAB2
entrez
8514
canonical
uniprot
Q13303
canonical
ensembl
ENSG00000069424
resolver
ensp
ENSP00000164247
resolver
ensp
ENSP00000318772
resolver
ensp
ENSP00000367323
resolver
ensp
ENSP00000367332
resolver
ensp
ENSP00000367337
resolver
ensp
ENSP00000367351
resolver
ensp
ENSP00000396167
resolver
ensp
ENSP00000400285
resolver
ensp
ENSP00000473602
resolver
ensp
ENSP00000499361
resolver
ensp
ENSP00000499370
resolver
ensp
ENSP00000499496
resolver
ensp
ENSP00000670704
resolver
genesymbol
KCNAB2
resolver
genesymbol_syn
KCNA2B
resolver
genesymbol_syn
KCNK2
resolver
hgnc
HGNC:6229
resolver
uniprot
A0AVM9
resolver
uniprot
A8K1A4
resolver
uniprot
B0AZR7
resolver
uniprot
B2R776
resolver
uniprot
O43659
resolver
uniprot
Q2YD85
resolver
uniprot
Q5TG82
resolver
uniprot
Q5TG83
resolver
uniprot
Q6ZNE4
resolver
uniprot
Q99411
resolver
uniprot_entry
B2R776_HUMAN
resolver
uniprot_entry
KCAB2_HUMAN
resolver
uniprot_sec
A0AVM9
resolver
uniprot_sec
A8K1A4
resolver
uniprot_sec
B0AZR7
resolver
uniprot_sec
O43659
resolver
uniprot_sec
Q2YD85
resolver
uniprot_sec
Q5TG82
resolver
uniprot_sec
Q5TG83
resolver
uniprot_sec
Q6ZNE4
resolver
uniprot_sec
Q99411
resolver
amino_acid_sequence
MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPYSKKDYRS
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
function
FUNCTION: Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:11825900, PubMed:7649300). The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:11825900, PubMed:7649300). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:11825900, PubMed:7649300). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates (By similarity). Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet) (By similarity). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). {ECO:0000250|UniProtKB:P62482, ECO:0000250|UniProtKB:P62483, ECO:0000269|PubMed:11825900, ECO:0000269|PubMed:7649300}.
uniprot
proteins
mass_dalton
41000
uniprot
proteins
mutagenesis
MUTAGEN 90; /note="Y->F: No effect on its activity in promoting KCNA4 channel closure."; /evidence="ECO:0000269|PubMed:11825900
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1. {ECO:0000250|UniProtKB:P62483}.
uniprot
proteins
protein_family
Shaker potassium channel beta subunit family
uniprot
proteins
pubmed
11086297
uniprot
proteins
pubmed
11825900
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21357749
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7649300
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62483}. Membrane {ECO:0000269|PubMed:11086297, ECO:0000269|PubMed:21357749}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P62483}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:11086297}. Synapse, synaptosome {ECO:0000269|PubMed:21357749}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P62483}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated. {ECO:0000250|UniProtKB:P62483}.
uniprot
proteins