Lif
entrez
16878
canonical
uniprot
P09056
canonical
ensembl
ENSMUSG00000034394
resolver
ensp
ENSMUSP00000036853
resolver
ensp
ENSMUSP00000067066
resolver
ensp
ENSMUSP00000237003
resolver
enst
ENSMUST00000040750
resolver
enst
ENSMUST00000066283
resolver
genesymbol
Lif
resolver
uniprot
F8WH42
resolver
uniprot_entry
F8WH42_MOUSE
resolver
uniprot_entry
LIF_MOUSE
resolver
amino_acid_sequence
MKVLAAGIVPLLLLVLHWKHGAGSPLPITPVNATCAIRHPCHGNLMNQIKNQLAQLNGSANALFISYYTAQGEPFPNNVEKLCAPNMTDFPSFHGNGTEKTKLVELYRMVAYLSASLTNITRDQKVLNPTAVSLQVKLNATIDVMRGLLSNVLCRLCNKYRVGHVDVPPVPDHSDKEAFQRKKLGCQLLGTYKQVISVVVQAF
uniprot
proteins
function
FUNCTION: Functions as a cytokine that binds to the LIF receptor complex (By similarity). The LIF receptor complex indeed consists of two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell (By similarity). Functionally, regulates cell self-renewal, differentiation and survival of embryonic stem cells (EScs) and is crucial for embryonic implantation (PubMed:1522892, PubMed:16452727, PubMed:26775702, PubMed:3127201, PubMed:3143916). Mechanistically, ligand binding to LIFR, induces heterodimerization with IL6ST/gp130 activating JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains (PubMed:8921810). These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (PubMed:8921810). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducers and activators of transcription (STAT3 and to lesser extent STAT1) (PubMed:8921810). In parallel to the activation of the STAT3-pathway, the binding of LIF to the LIF receptor complex leads to the activation of the mitogen-activated protein kinase (MAPK) and the phosphatidylinositol 3-kinase (PI(3)K) pathways (PubMed:15328362, PubMed:9545305). Tyrosine phosphorylation of the p85 subunit of PI(3)K by JAK1 leads to activation of the serine/ threonine kinase AKT (protein kinase B) (PubMed:9545305). PI(3)K-dependent signaling is required for efficient self-renewal of murine ES cells, and regulation of ERK activity is functionally important in this response (PubMed:15328362). Moreover, induces tyrosine phosphorylation of PTPN11, that associates with IL6ST/gp130-LIFR, which in turn recruits the p85 regulatory subunit of PI(3)K protein kinase, promoting PI3K-AKT activation, and (in many systems) GRB2-RAS-MAPK signaling (By similarity). {ECO:0000250|UniProtKB:P15018, ECO:0000269|PubMed:1522892, ECO:0000269|PubMed:15328362, ECO:0000269|PubMed:16452727, ECO:0000269|PubMed:26775702, ECO:0000269|PubMed:3127201, ECO:0000269|PubMed:3143916, ECO:0000269|PubMed:8921810, ECO:0000269|PubMed:9545305}.
uniprot
proteins
mass_dalton
22287
uniprot
proteins
protein_family
LIF/OSM family
uniprot
proteins
pubmed
10438970
uniprot
proteins
pubmed
1522892
uniprot
proteins
pubmed
15328362
uniprot
proteins
pubmed
16452727
uniprot
proteins
pubmed
1692837
uniprot
proteins
pubmed
2475312
uniprot
proteins
pubmed
26775702
uniprot
proteins
pubmed
3127201
uniprot
proteins
pubmed
3143916
uniprot
proteins
pubmed
3147726
uniprot
proteins
pubmed
3186448
uniprot
proteins
pubmed
8020098
uniprot
proteins
pubmed
8422244
uniprot
proteins
pubmed
8921810
uniprot
proteins
pubmed
9254611
uniprot
proteins
pubmed
9545305
uniprot
proteins
pubmed
9593715
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P15018}.
uniprot
proteins