HES1
entrez
3280
canonical
uniprot
Q14469
canonical
ensembl
ENSG00000114315
resolver
ensp
ENSP00000232424
resolver
enst
ENST00000232424
resolver
genesymbol
HES1
resolver
genesymbol_syn
BHLHB39
resolver
genesymbol_syn
HL
resolver
genesymbol_syn
HRY
resolver
hgnc
HGNC:5192
resolver
uniprot
Q6FHB2
resolver
uniprot_entry
HES1_HUMAN
resolver
uniprot_sec
Q6FHB2
resolver
amino_acid_sequence
MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRPWRN
uniprot
proteins
function
FUNCTION: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. {ECO:0000250, ECO:0000269|PubMed:18550849}.
uniprot
proteins
mass_dalton
29541
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Ubiquitinated via human cytomegalovirus/HCMV protein IE1 that assembles a HES1 ubiquitination complex; leading to HES1 proteasomal degradation. {ECO:0000269|PubMed:28750047}.
uniprot
proteins
pubmed
12535671
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
18550849
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28750047
uniprot
proteins
pubmed
8020957
uniprot
proteins
sequence_length
280
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28750047}.
uniprot
proteins