LIMS1
entrez
3987
canonical
uniprot
P48059
canonical
ensembl
ENSG00000169756
resolver
ensp
ENSP00000331775
resolver
ensp
ENSP00000337598
resolver
ensp
ENSP00000376987
resolver
ensp
ENSP00000386926
resolver
ensp
ENSP00000387264
resolver
ensp
ENSP00000399267
resolver
ensp
ENSP00000437912
resolver
ensp
ENSP00000511979
resolver
ensp
ENSP00000511980
resolver
ensp
ENSP00000511981
resolver
ensp
ENSP00000511982
resolver
ensp
ENSP00000511985
resolver
enst
ENST00000414829
resolver
enst
ENST00000695516
resolver
enst
ENST00000695517
resolver
enst
ENST00000695519
resolver
enst
ENST00000695522
resolver
genesymbol
LIMS1
resolver
genesymbol_syn
PINCH
resolver
genesymbol_syn
PINCH1
resolver
hgnc
HGNC:6616
resolver
uniprot
A0A8Q3WKI3
resolver
uniprot
A0A8Q3WKJ2
resolver
uniprot
A0A8Q3WKK6
resolver
uniprot
A0A8Q3WKP0
resolver
uniprot
B2RAJ4
resolver
uniprot
B7Z483
resolver
uniprot
B7Z7R3
resolver
uniprot
B7Z907
resolver
uniprot
F8WC86
resolver
uniprot
Q53TE0
resolver
uniprot
Q9BS44
resolver
uniprot_entry
A0A8Q3WKI3_HUMAN
resolver
uniprot_entry
A0A8Q3WKJ2_HUMAN
resolver
uniprot_entry
A0A8Q3WKK6_HUMAN
resolver
uniprot_entry
A0A8Q3WKP0_HUMAN
resolver
uniprot_entry
F8WC86_HUMAN
resolver
uniprot_entry
LIMS1_HUMAN
resolver
uniprot_sec
B2RAJ4
resolver
uniprot_sec
B7Z483
resolver
uniprot_sec
B7Z7R3
resolver
uniprot_sec
B7Z907
resolver
uniprot_sec
Q53TE0
resolver
uniprot_sec
Q9BS44
resolver
amino_acid_sequence
MANALASATCERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVIEGDVVSALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVCKKCYEKFPLELKKRLKKLAETLGRK
uniprot
proteins
function
FUNCTION: Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration. {ECO:0000269|PubMed:30367047}.
uniprot
proteins
mass_dalton
37251
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="Q->A: Loss of interaction with ILK and loss of localization to focal adhesions."; /evidence="ECO:0000269|PubMed:12432066"; MUTAGEN 42; /note="F->A: Loss of interaction with ILK and loss of localization to focal adhesions."; /evidence="ECO:0000269|PubMed:19074270, ECO:0000269|PubMed:19117955"; MUTAGEN 56; /note="R->A: Alters interaction with ILK."; /evidence="ECO:0000269|PubMed:19117955"; MUTAGEN 61; /note="H->D: Alters interaction with ILK."; /evidence="ECO:0000269|PubMed:19074270"; MUTAGEN 62; /note="D->A: Alters interaction with ILK."; /evidence="ECO:0000269|PubMed:19074270"; MUTAGEN 66; /note="L->D: Alters interaction with ILK."; /evidence="ECO:0000269|PubMed:19074270"; MUTAGEN 307..313; /note="FPLELKK->APLEAAA: Reduced actin binding and reduced F-actin bundling. Impaired cell spreading."; /evidence="ECO:0000269|PubMed:30367047
uniprot
proteins
pubmed
10022929
uniprot
proteins
pubmed
10508479
uniprot
proteins
pubmed
11078733
uniprot
proteins
pubmed
11331308
uniprot
proteins
pubmed
12432066
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12794636
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19074270
uniprot
proteins
pubmed
19117955
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
30367047
uniprot
proteins
pubmed
7517666
uniprot
proteins
pubmed
9843575
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:12432066}. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
uniprot
proteins