Cish
entrez
12700
canonical
uniprot
Q62225
canonical
ensembl
ENSMUSG00000032578
resolver
ensp
ENSMUSP00000082183
resolver
enst
ENSMUST00000085102
resolver
genesymbol
Cish
resolver
genesymbol_syn
Cis
resolver
uniprot
Q3TC70
resolver
uniprot
Q8C3F4
resolver
uniprot_entry
CISH_MOUSE
resolver
uniprot_entry
Q8C3F4_MOUSE
resolver
uniprot_sec
Q3TC70
resolver
amino_acid_sequence
MVLCVQGSCPLLAVEQIGRRPLWAQSLELPGPAMQPLPTGAFPEEVTEETPVQAENEPKVLDPEGDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCAADTRSDSPDPAPTPALPMSKQDAPSDSVLPIPVATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDCLPLPRRMADYLRQYPFQL
uniprot
proteins
function
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250, ECO:0000269|PubMed:9129017}.
uniprot
proteins
mass_dalton
28537
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
7796808
uniprot
proteins
pubmed
9129017
uniprot
proteins
sequence_length
257
uniprot
proteins