Q5U431
uniprot
Q5U431
canonical
amino_acid_sequence
MASSSGSNHICSRVIDHSHVPEFEVATWIKITLILVYLIIFVVGILGNSVTIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTPSYALSCKLHTFLFETCSYATLLHVLTLSFERYIAICHPFKYKAVSGPRQVKLLIGFVWVTSALVALPLLFAMGIEYPLVNVPTHKGLNCNLSRTRHHDEPGNSNMSICTNLSNRWEVFQSSIFGAFAVYLVVLASVAFMCWNMMKVLMKSKQGTLAGTGPQLQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRTYFRAYMILLPFSDTFFYLSSVVNPLLYNVSSQQFRKVFWQVLCCRLTLQHANQEKRQRARFISTKDSTSSARSPLIFLASRRSNSSSRRTNKVFLSTFQTEAKPGEAKPQPLSPESPQTGSETKPAGSTTENSLQEQEV
uniprot
proteins
function
FUNCTION: Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed:17030183, PubMed:18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (By similarity). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (PubMed:31346193). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (PubMed:21784784). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner. Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity: HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (By similarity). {ECO:0000250|UniProtKB:O43194, ECO:0000269|PubMed:17030183, ECO:0000269|PubMed:18180304, ECO:0000269|PubMed:21784784, ECO:0000269|PubMed:31346193}.
uniprot
proteins
mass_dalton
51589
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959833
uniprot
proteins
pubmed
17030183
uniprot
proteins
pubmed
18180304
uniprot
proteins
pubmed
21784784
uniprot
proteins
pubmed
31346193
uniprot
proteins
pubmed
36087899
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O43194}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O43194}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..55; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 70..89; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 110..131; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 152..172; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 218..242; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 284..305; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 324..344; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P20789
uniprot
proteins