Ccn1
entrez
83476
canonical
uniprot
Q9ES72
canonical
genesymbol
Ccn1
resolver
genesymbol_syn
Cyr61
resolver
genesymbol_syn
Igfbp10
resolver
uniprot
Q66HT5
resolver
uniprot_entry
CCN1_RAT
resolver
uniprot_entry
Q66HT5_RAT
resolver
amino_acid_sequence
MSSSTIKTLAVAVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVSGQCCEEWVCDEDSIKDSLDDQDDLLGFDASEVELTRNNELIAIGKGSSLKRLPVFGTEPRVLYNPLHAHGQKCIVQTTSWSQCSKSCGTGISTRVTNDNSECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTYAGCSSVKKYRPKYCGSCVDGRCCTPLQTRTVKMRFRCEDGEMFSKNVMMIQSCKCNYNCPHPNEASFRLYSLFNDIHKFRD
uniprot
proteins
function
FUNCTION: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
41687
uniprot
proteins
protein_family
CCN family
uniprot
proteins
pubmed
10852911
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins