FHDC1
entrez
85462
canonical
uniprot
Q9C0D6
canonical
ensembl
ENSG00000137460
resolver
ensp
ENSP00000427567
resolver
ensp
ENSP00000546737
resolver
ensp
ENSP00000546738
resolver
ensp
ENSP00000607806
resolver
ensp
ENSP00000612520
resolver
enst
ENST00000511601
resolver
enst
ENST00000876678
resolver
enst
ENST00000876679
resolver
enst
ENST00000942461
resolver
genesymbol
FHDC1
resolver
genesymbol_syn
INF1
resolver
genesymbol_syn
KIAA1727
resolver
hgnc
HGNC:29363
resolver
uniprot_entry
FHDC1_HUMAN
resolver
amino_acid_sequence
MHVMNCVSLVSDKENGNIATAPGFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPTTHMNGYSHLGKKKRMRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAIEKLRELECWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEQEQKQRSWATGELGAFGRSSSENDVELLTKKGAEGLLPFLHPRPISPSSPSYRPPNTRRSRLSLGPSADRELLTFLESSTGSPEEPNKFHSLPRSSPRQARPTIACLEPAEVRHQDSSFAHKPQASGGQEEAPNPPSAQAHQLAAAQPENHASAFPRARRQGVSVLRKRYSEPVSLGSAQSPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQLTLSDFSPMELESVGHRGPQSLSASSSSLTPMGRDALGSLSPALEDGKAAPDEPGSAALGSVGSSDPENKDPRPLFCISDTTDCSLTLDCSEGTDSRPRGGDPEEGGEGDGSMSSGVGEMGDSQVSSNPTSSPPGEAPAPVSVDSEPSCKGGLPRDKPTKRKDVVAPKRGSLKEASPGASKPGSARRSQGAVAKSVRTLTASENESMRKVMPITKSSRGAGWRRPELSSRGPSQNPPSSTDTVWSRQNSVRRASTGAEEQRLPRGSSGSSSTRPGRDVPLQPRGSFKKPSAKPLRNLPRQKPEENKTCRAHSEGPESPKEEPKTPSVPSVPHELPRVPSFARNTVASSSRSMRTDLPPVAKAPGITRTVSQRQLRVKGDPEDAAPKDSSTLRRASSARAPKKRPESAEGPSANTEAPLKARGAGERASLRRKDSSRTTLGRILNPLRK
uniprot
proteins
function
FUNCTION: Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}.
uniprot
proteins
mass_dalton
124762
uniprot
proteins
mutagenesis
MUTAGEN 180; /note="I->A: Loss of actin-binding and ability to induce Golgi ribbon formation. Induces a significant increase in average cilia length."; /evidence="ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020
uniprot
proteins
pubmed
11214970
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18815276
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23033978
uniprot
proteins
pubmed
26564798
uniprot
proteins
pubmed
29742020
uniprot
proteins
sequence_length
1143
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:29742020}. Golgi apparatus {ECO:0000250|UniProtKB:Q3ULZ2}. Note=Associates with microtubules. {ECO:0000269|PubMed:18815276}.
uniprot
proteins