Mest
entrez
17294
canonical
uniprot
Q07646
canonical
ensembl
ENSMUSG00000051855
resolver
ensp
ENSMUSP00000117713
resolver
ensp
ENSMUSP00000119038
resolver
ensp
ENSMUSP00000129639
resolver
ensp
ENSMUSP00000290555
resolver
enst
ENSMUST00000124665
resolver
genesymbol
Mest
resolver
genesymbol_syn
Peg1
resolver
uniprot
D3Z383
resolver
uniprot
Q792T8
resolver
uniprot
Q8BS88
resolver
uniprot
Q8K463
resolver
uniprot
Q99KT5
resolver
uniprot_entry
D3Z383_MOUSE
resolver
uniprot_entry
MEST_MOUSE
resolver
uniprot_sec
Q792T8
resolver
uniprot_sec
Q8BS88
resolver
uniprot_sec
Q8K463
resolver
uniprot_sec
Q99KT5
resolver
amino_acid_sequence
MVRRDRLRRMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKTSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHQYSIFEQASIVESLLRHLGLQNRRINLLSHDYGDIVAQELLYRYKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLKDGGVLSPILTRLMNFFVFSRGLTPVFGPYTRPTESELWDMWAVIRNNDGNLVIDSLLQYINQRKKFRRRWVGALASVSIPIHFIYGPLDPINPYPEFLELYRKTLPRSTVSILDDHISHYPQLEDPMGFLNAYMGFINSF
uniprot
proteins
ec_number
3.-.-.-
uniprot
proteins
function
FUNCTION: Plays an important role in enabling neurons to transition from bipolar to multipolar shapes, a process essential for their correct migration toward the cortical plate during brain development (PubMed:28501506). This function is likely achieved through the regulation of N-cadherin-dependent cell adhesion and the modulation of Akt and canonical Wnt signaling pathways (PubMed:28501506). Essential for the development and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed:28133444). Negatively regulates the canonical Wnt signaling pathway during adipogenic differentiation by reducing the glycosylation, maturation, and cell membrane localization of the Wnt coreceptor LRP6 (PubMed:21375506). {ECO:0000269|PubMed:21375506, ECO:0000269|PubMed:28133444, ECO:0000269|PubMed:28501506}.
uniprot
proteins
mass_dalton
38907
uniprot
proteins
mutagenesis
MUTAGEN 147; /note="D->A: No effect on inhibition of canonical Wnt signaling pathway."; /evidence="ECO:0000269|PubMed:21375506
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
12095916
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18644838
uniprot
proteins
pubmed
21375506
uniprot
proteins
pubmed
28133444
uniprot
proteins
pubmed
28501506
uniprot
proteins
pubmed
29058774
uniprot
proteins
pubmed
7550314
uniprot
proteins
pubmed
9302270
uniprot
proteins
sequence_length
335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18644838, ECO:0000269|PubMed:29058774, ECO:0000305|PubMed:21375506}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 63..83; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 266..286; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins