Pick1
entrez
84591
canonical
uniprot
Q9EP80
canonical
ensembl
ENSRNOG00000011507
resolver
ensembl
ENSRNOG00055031568
resolver
ensembl
ENSRNOG00060023479
resolver
ensembl
ENSRNOG00065033195
resolver
ensp
ENSRNOP00000016077
resolver
ensp
ENSRNOP00055045205
resolver
ensp
ENSRNOP00060033658
resolver
ensp
ENSRNOP00065046975
resolver
enst
ENSRNOT00000016077
resolver
enst
ENSRNOT00055054692
resolver
enst
ENSRNOT00060040717
resolver
enst
ENSRNOT00065057081
resolver
genesymbol
Pick1
resolver
genesymbol_syn
Prkcabp
resolver
uniprot
A0ACM8Q4D5
resolver
uniprot
A6HSQ7
resolver
uniprot
Q546X4
resolver
uniprot
Q6GQQ2
resolver
uniprot
Q925D1
resolver
uniprot_entry
A0ACM8Q4D5_RAT
resolver
uniprot_entry
A6HSQ7_RAT
resolver
uniprot_entry
PICK1_RAT
resolver
uniprot_sec
Q546X4
resolver
uniprot_sec
Q6GQQ2
resolver
uniprot_sec
Q925D1
resolver
amino_acid_sequence
MFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDNTPAALDGTVAAGDEITGVNGRSIKGKTKVEVAKMIQEVKGEVTIHYNKLQADPKQGMSLDIVLKKVKHRLVENMSSGTADALGLSRAILCNDGLVKRLEELERTAELYKGMTEHTKNLLRAFYELSQTHRAFGDVFSVIGVREPQPAASEAFVKFADAHRSIEKFGIRLLKTIKPMLTDLNTYLNKAIPDTRLTIKKYLDVKFEYLSYCLKVKEMDDEEYSCIALGEPLYRVSTGNYEYRLILRCRQEARARFSQMRKDVLEKMELLDQKHVQDIVFQLQRFVSTMSKYYNDCYAVLRDADVFPIEVDLAHTTLAYGPNQGGFTDGEDEEEEEEDGAAREVSKDARGATGPTDKGGSWCDS
uniprot
proteins
function
FUNCTION: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. {ECO:0000269|PubMed:16138078, ECO:0000269|PubMed:18297063, ECO:0000269|PubMed:21252856, ECO:0000269|PubMed:23843614}.
uniprot
proteins
mass_dalton
46606
uniprot
proteins
mutagenesis
MUTAGEN 27..28; /note="KD->AA: Abolishes interaction with other proteins, but not with itself."; /evidence="ECO:0000269|PubMed:10027300, ECO:0000269|PubMed:11122333, ECO:0000269|PubMed:11375398, ECO:0000269|PubMed:23889934"; MUTAGEN 44; /note="C->G: Decreased lipid membrane binding, but no effect on peptide ligand recognition."; /evidence="ECO:0000269|PubMed:17914463"; MUTAGEN 46; /note="C->G: Decreased lipid membrane binding, but no effect on peptide ligand recognition."; /evidence="ECO:0000269|PubMed:17914463"; MUTAGEN 79; /note="K->E: No effect on lipid membrane binding."; /evidence="ECO:0000269|PubMed:17914463"; MUTAGEN 81; /note="K->E: No effect on lipid membrane binding."; /evidence="ECO:0000269|PubMed:17914463"; MUTAGEN 251..252; /note="KK->EE: Abolishes F-actin binding and the inhibitory function on Arp2/3 complex-mediated actin nucleation, impairs lipid vesicle interaction, no effect on Arp2/3 complex association."; /evidence="ECO:0000269|PubMed:18297063"; MUTAGEN 413; /note="W->A: Abolishes association with Arp2/3 complex and the inhibitory function on Arp2/3 complex-mediated actin nucleation."; /evidence="ECO:0000269|PubMed:18297063
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors. {ECO:0000250}.; PTM: Palmitoylation on Cys-414 is essential for long-term synaptic depression (LTD). {ECO:0000250}.
uniprot
proteins
pubmed
10027300
uniprot
proteins
pubmed
10340301
uniprot
proteins
pubmed
11122333
uniprot
proteins
pubmed
11237868
uniprot
proteins
pubmed
11375398
uniprot
proteins
pubmed
11931741
uniprot
proteins
pubmed
14672991
uniprot
proteins
pubmed
16138078
uniprot
proteins
pubmed
17914463
uniprot
proteins
pubmed
18297063
uniprot
proteins
pubmed
18429931
uniprot
proteins
pubmed
19109914
uniprot
proteins
pubmed
21252856
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23843614
uniprot
proteins
pubmed
23889934
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:23889934}. Membrane {ECO:0000269|PubMed:23889934}; Peripheral membrane protein {ECO:0000269|PubMed:23889934}. Membrane {ECO:0000250|UniProtKB:Q62083}; Lipid-anchor {ECO:0000250|UniProtKB:Q62083}. Postsynaptic density {ECO:0000269|PubMed:23889934}. Synapse, synaptosome {ECO:0000269|PubMed:23889934}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23889934}. Note=Also membrane-associated, present at excitatory synapses.
uniprot
proteins