Nrbf2
entrez
58839
canonical
uniprot
Q9QYK3
canonical
ensembl
ENSRNOG00000000641
resolver
ensp
ENSRNOP00000000794
resolver
enst
ENSRNOT00000000794
resolver
genesymbol
Nrbf2
resolver
uniprot
G3V622
resolver
uniprot_entry
G3V622_RAT
resolver
uniprot_entry
NRBF2_RAT
resolver
amino_acid_sequence
MEVMEGPLNLAHQQSRRADRLLAAGKYEEAISCHKKATAYLSEAMKLTQSEQAHLSLELQRDSHMKQLLLIQERWKRAKREERLKAQQSTDRDGVPHLQASHRPSEDSEGQSPLLSQTYIPSTEKRLPEEQGVFDRDPDTLLFLLQQKNEPSEPCIGSKAPKDDKTIIEEQATKIAELKRHVEFLVAENERLRKENKQLKAEKARLLKGPAEKELDVDADFVEKSELWGLPPHSDTATASSTWQKFAANTGKAKDIPIPNLPPLDFPSPELPLMELSEDILKGFMND
uniprot
proteins
function
FUNCTION: May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). {ECO:0000269|PubMed:10786636}.; FUNCTION: Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VCQ3, ECO:0000250|UniProtKB:Q96F24}.
uniprot
proteins
mass_dalton
32558
uniprot
proteins
protein_family
NRBF family
uniprot
proteins
pubmed
10786636
uniprot
proteins
pubmed
18619852
uniprot
proteins
sequence_length
287
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10786636}. Cytoplasm {ECO:0000269|PubMed:10786636}. Cytoplasmic vesicle, autophagosome {ECO:0000305}.
uniprot
proteins