Acy3
entrez
71670
canonical
uniprot
Q91XE4
canonical
ensembl
ENSMUSG00000024866
resolver
ensp
ENSMUSP00000050056
resolver
ensp
ENSMUSP00000158093
resolver
ensp
ENSMUSP00000158512
resolver
ensp
ENSMUSP00000225327
resolver
enst
ENSMUST00000054030
resolver
enst
ENSMUST00000235612
resolver
enst
ENSMUST00000236510
resolver
genesymbol
Acy3
resolver
genesymbol_syn
Aspa2
resolver
uniprot
Q3UP59
resolver
uniprot
Q9DD17
resolver
uniprot_entry
ACY3_MOUSE
resolver
uniprot_sec
Q3UP59
resolver
uniprot_sec
Q9DD17
resolver
amino_acid_sequence
MSSLPGSREPLLRVAVTGGTHGNEMCGVYLARYWLQNPGELQRPSFSAMPVLANPAATAACCRYLDRDLNRSCTLTFLGSTATPDDPYEVKRARELNQLLGPKGTGQAFDFTLDLHNTTANTGVCLISESNISFNLHLCHYLQRQNPGMPCRLFLYEPAGTETFSVESISKNGICLEMGPQPQGVLRADLFSRMRALVASILDFIELFNQGMDLPAFEMDIYRNLGSVDFPRTADGDLAGTVHPQLQDHDFEPLRPGEPIFKLFSGEDVLYEGDSIVYPVFINEAAYYEKHVAFLKSEKIRVTVPALLRLTPRSTQTP
uniprot
proteins
ec_number
3.5.1.114
uniprot
proteins
function
FUNCTION: Deacetylates N-acetyl aromatic amino acids and mercapturic acids (N-acetyl-L-cysteine-S-conjugates), including halogenated mercapturic acids derived from the metabolism of environmental contaminants such as trichloroethylene, making it a key enzyme in the processing of both endogenous and xenobiotic compounds (PubMed:14656720, PubMed:17012540). In neurons and blood vessels, deacetylates the mercapturates of 4-hydroxy-2-nonenal (4HNE) and acrolein (ACR), two highly reactive lipid peroxidation products; the resulting deacetylated products can then be transformed into toxic compounds by beta-lyase (PubMed:22819785). {ECO:0000269|PubMed:14656720, ECO:0000269|PubMed:17012540, ECO:0000269|PubMed:22819785}.
uniprot
proteins
mass_dalton
35286
uniprot
proteins
mutagenesis
MUTAGEN 63; /note="R->A: Abolishes activity."; /evidence="ECO:0000269|PubMed:20921362"; MUTAGEN 287; /note="Y->A: Drastically reduced activity."; /evidence="ECO:0000269|PubMed:20921362
uniprot
proteins
protein_family
AspA/AstE family
uniprot
proteins
protein_family
Aspartoacylase subfamily
uniprot
proteins
pubmed
14656720
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17012540
uniprot
proteins
pubmed
17434493
uniprot
proteins
pubmed
20921362
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22819785
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:14656720}; Peripheral membrane protein {ECO:0000269|PubMed:14656720}. Cytoplasm {ECO:0000269|PubMed:14656720}. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm.
uniprot
proteins