Tsku
entrez
308843
canonical
uniprot
Q6QMY6
canonical
ensembl
ENSRNOG00000027784
resolver
ensp
ENSRNOP00000029957
resolver
ensp
ENSRNOP00000078677
resolver
ensp
ENSRNOP00000080766
resolver
ensp
ENSRNOP00000086216
resolver
ensp
ENSRNOP00000090380
resolver
ensp
ENSRNOP00000093869
resolver
ensp
ENSRNOP00000103897
resolver
enst
ENSRNOT00000034843
resolver
enst
ENSRNOT00000099039
resolver
enst
ENSRNOT00000105524
resolver
enst
ENSRNOT00000111957
resolver
enst
ENSRNOT00000114498
resolver
enst
ENSRNOT00000114784
resolver
enst
ENSRNOT00000125977
resolver
genesymbol
Tsku
resolver
genesymbol_syn
Eiih
resolver
genesymbol_syn
Lrrc54
resolver
genesymbol_syn
Tsk
resolver
uniprot
A0A8I6AJP3
resolver
uniprot
A0A8I6G739
resolver
uniprot
G3V8X6
resolver
uniprot_entry
A0A8I6G739_RAT
resolver
uniprot_entry
TSK_RAT
resolver
uniprot_sec
A0A8I6AJP3
resolver
uniprot_sec
G3V8X6
resolver
amino_acid_sequence
MLCTLFLLLLALGIVQTTRPCFPGCQCEEETFGLFDSFSLIRVDCSSLGPHIVPVPIPLDTAHLDLSSNRLETVNESVLGGPGYTTLAGLDLSHNLLTSITPTAFSRLRYLESLDLSHNGLAALPAEVFTSSPLSDINLSHNRLREVSISAFTTHSQGRALHVDLSHNLIHRLLPYPARASLSAPTIQSLNLSWNRLRAVPDLRDLPLRYLSLDGNPLATINPGAFMGLAGLTHLSLASLQGILQLPPHGFRELPGLQVLDLSGNPKLKWAGAEVFSGLGLLQELDLSGSSLVPLPETLLHHLPALQSVSVGQDVQCRRLVREGAYHRQPGSSPKVVLHCGDTQESARGPDIL
uniprot
proteins
function
FUNCTION: Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways. Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye. Plays a role in regulating the hair cycle by controlling TGFB1 signaling. Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth. Essential for terminal differentiation of hippocampal neural stem cells. Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size. Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells. Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence. Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver. In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure. In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis. {ECO:0000250|UniProtKB:Q8CBR6}.
uniprot
proteins
mass_dalton
38091
uniprot
proteins
pubmed
15344907
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8CBR6}.
uniprot
proteins