ELOVL3
entrez
83401
canonical
uniprot
Q9HB03
canonical
ensembl
ENSG00000119915
resolver
ensp
ENSP00000359022
resolver
enst
ENST00000370005
resolver
genesymbol
ELOVL3
resolver
genesymbol_syn
CIG30
resolver
hgnc
HGNC:18047
resolver
uniprot
Q5VZL3
resolver
uniprot
Q8N180
resolver
uniprot_entry
ELOV3_HUMAN
resolver
uniprot_sec
Q5VZL3
resolver
uniprot_sec
Q8N180
resolver
amino_acid_sequence
MVTAMNVSHEVNQLFQPYNFELSKDMRPFFEEYWATSFPIALIYLVLIAVGQNYMKERKGFNLQGPLILWSFCLAIFSILGAVRMWGIMGTVLLTGGLKQTVCFINFIDNSTVKFWSWVFLLSKVIELGDTAFIILRKRPLIFIHWYHHSTVLVYTSFGYKNKVPAGGWFVTMNFGVHAIMYTYYTLKAANVKPPKMLPMLITSLQILQMFVGAIVSILTYIWRQDQGCHTTMEHLFWSFILYMTYFILFAHFFCQTYIRPKVKAKTKSQ
uniprot
proteins
ec_number
2.3.1.199
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000255|HAMAP-Rule:MF_03203, ECO:0000269|PubMed:20937905}.
uniprot
proteins
mass_dalton
31500
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03203, ECO:0000269|PubMed:20937905}.
uniprot
proteins
post_translational_modification
PTM: N-Glycosylated. {ECO:0000255|HAMAP-Rule:MF_03203, ECO:0000269|PubMed:20937905}.
uniprot
proteins
protein_family
ELO family
uniprot
proteins
protein_family
ELOVL3 subfamily
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19575253
uniprot
proteins
pubmed
20937905
uniprot
proteins
pubmed
38422897
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03203, ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03203}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..49; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03203"; TRANSMEM 63..83; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03203"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03203"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03203"; TRANSMEM 164..184; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03203"; TRANSMEM 198..218; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03203"; TRANSMEM 235..255; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03203
uniprot
proteins