DUSP28
entrez
285193
canonical
uniprot
Q4G0W2
canonical
ensembl
ENSG00000188542
resolver
ensp
ENSP00000344235
resolver
ensp
ENSP00000385885
resolver
enst
ENST00000343217
resolver
enst
ENST00000405954
resolver
genesymbol
DUSP28
resolver
hgnc
HGNC:33237
resolver
uniprot_entry
DUS28_HUMAN
resolver
amino_acid_sequence
MGPAEAGRRGAASPVPPPLVRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQAQSCLQGEPPALGLGPEA
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro) (PubMed:24531476, PubMed:29121083). Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine (PubMed:29121083). The poor activity with phosphotyrosine may be due to steric hindrance by bulky amino acid sidechains that obstruct access to the active site (PubMed:29121083). {ECO:0000269|PubMed:24531476, ECO:0000269|PubMed:29121083}.
uniprot
proteins
mass_dalton
18324
uniprot
proteins
mutagenesis
MUTAGEN 102; /note="Y->H: Decreases the already low catalytic activity."; /evidence="ECO:0000269|PubMed:29121083"; MUTAGEN 103; /note="C->S: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:29121083"; MUTAGEN 105; /note="N->A: Increases activity with phosphotyrosine; when associated with V-107."; /evidence="ECO:0000269|PubMed:29121083"; MUTAGEN 107; /note="R->V: Increases activity with phosphotyrosine; when associated with A-105."; /evidence="ECO:0000269|PubMed:29121083
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24531476
uniprot
proteins
pubmed
29121083
uniprot
proteins
sequence_length
176
uniprot
proteins