Q9JLV6
uniprot
Q9JLV6
canonical
amino_acid_sequence
MSQLGSRGRLWLQSPTGGPPPIFLPSDGQALVLGRGPLTQVTDRKCSRNQVELIADPESRTVAVKQLGVNPSTVGVHELKPGLSGSLSLGDVLYLVNGLYPLTLRWEELSTSGSQPDAPPDTPGDPEEGEDTEPQKKRVRKSSLGWESLKKLLVFTASGVKPQGKVAAFDLDGTLITTRSGKVFPTSPSDWRILYPEIPKKLQELAAEGYKLVIFTNQMGIGRGKLPAEVFKGKVEAVLEKLGVPFQVLVATHAGLNRKPVSGMWDHLQEQANEGIPISVEDSVFVGDAAGRLANWAPGRKKKDFSCADRLFALNVGLPFATPEEFFLKWPAARFELPAFDPRTISSAGPLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYVHVNRDTLGSWQRCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCAKDAGVPCRCFNFCATIEQARHNNRFREMTDPSHAPVSDMVMFSYRKQFEPPTLAEGFLEILEIPFRLQEHLDPALQRLYRQFSEG
uniprot
proteins
ec_number
2.7.1.78
uniprot
proteins
ec_number
3.1.3.32
uniprot
proteins
function
FUNCTION: Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. {ECO:0000250|UniProtKB:Q96T60}.
uniprot
proteins
mass_dalton
57223
uniprot
proteins
mutagenesis
MUTAGEN 44; /note="R->A: Abrogates phosphopeptide recognition."; /evidence="ECO:0000269|PubMed:15749016"; MUTAGEN 45; /note="K->N: No effect on phosphopeptide recognition."; /evidence="ECO:0000269|PubMed:15749016"; MUTAGEN 48; /note="R->A: Abrogates phosphopeptide recognition."; /evidence="ECO:0000269|PubMed:15749016
uniprot
proteins
protein_family
DNA 3' phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15749016
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
522
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96T60}.
uniprot
proteins