Snx3
entrez
684097
canonical
uniprot
Q5U211
canonical
ensembl
ENSRNOG00000046705
resolver
ensembl
ENSRNOG00055000791
resolver
ensembl
ENSRNOG00060006605
resolver
ensembl
ENSRNOG00065008686
resolver
ensp
ENSRNOP00000087527
resolver
ensp
ENSRNOP00000092005
resolver
ensp
ENSRNOP00055001101
resolver
ensp
ENSRNOP00060008076
resolver
ensp
ENSRNOP00065010260
resolver
enst
ENSRNOT00000075924
resolver
enst
ENSRNOT00055001369
resolver
enst
ENSRNOT00060010863
resolver
enst
ENSRNOT00065013811
resolver
genesymbol
Snx3
resolver
genesymbol_syn
LOC684097
resolver
uniprot
B0BMY2
resolver
uniprot_entry
B0BMY2_RAT
resolver
uniprot_entry
SNX3_RAT
resolver
amino_acid_sequence
MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
uniprot
proteins
function
FUNCTION: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC). May act in part as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor Tfrc presuambly by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex. Involved in regulation of neurite outgrowth in primary neurons. Required for trafficking of WLS to the early endosome for recycling which promotes both canonical and non-canonical WNT signaling and is essential for neural tube closure. {ECO:0000250|UniProtKB:O60493, ECO:0000250|UniProtKB:O70492}.
uniprot
proteins
mass_dalton
18762
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP10 (By similarity). {ECO:0000250|UniProtKB:O70492}.
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000250|UniProtKB:O60493, ECO:0000250|UniProtKB:O70492}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:O60493}. Note=Colocalizes to clathrin-coated endosomal vesicles morphologically distinct from retromer-decorated non-branched endosomal tubule structures. Colocalizes with EEA1 on nascent phagosomes in dendritic cells but competes with EEA1 for binding to phagosomal membrane (By similarity). {ECO:0000250|UniProtKB:O60493, ECO:0000250|UniProtKB:O70492}.
uniprot
proteins