PXYLP1
entrez
92370
canonical
uniprot
Q8TE99
canonical
ensembl
ENSG00000155893
resolver
ensp
ENSP00000286353
resolver
ensp
ENSP00000376733
resolver
ensp
ENSP00000422558
resolver
ensp
ENSP00000422901
resolver
ensp
ENSP00000426877
resolver
ensp
ENSP00000549163
resolver
ensp
ENSP00000595289
resolver
ensp
ENSP00000595290
resolver
ensp
ENSP00000641972
resolver
ensp
ENSP00000641974
resolver
ensp
ENSP00000641978
resolver
enst
ENST00000502783
resolver
enst
ENST00000504264
resolver
enst
ENST00000508812
resolver
genesymbol
PXYLP1
resolver
genesymbol_syn
ACPL2
resolver
genesymbol_syn
HEL124
resolver
genesymbol_syn
XYLP
resolver
hgnc
HGNC:26303
resolver
uniprot
B7Z3R9
resolver
uniprot
B7Z4T2
resolver
uniprot
D3DNF5
resolver
uniprot
E9PDB7
resolver
uniprot
F6R0G4
resolver
uniprot
F6S1K2
resolver
uniprot
Q49AJ2
resolver
uniprot
W0TR04
resolver
uniprot_entry
B7Z3R9_HUMAN
resolver
uniprot_entry
B7Z4T2_HUMAN
resolver
uniprot_entry
E9PDB7_HUMAN
resolver
uniprot_entry
F6R0G4_HUMAN
resolver
uniprot_entry
F6S1K2_HUMAN
resolver
uniprot_entry
PXYP1_HUMAN
resolver
uniprot_sec
D3DNF5
resolver
uniprot_sec
Q49AJ2
resolver
uniprot_sec
W0TR04
resolver
amino_acid_sequence
MLFRNRFLLLLALAALLAFVSLSLQFFHLIPVSTPKNGMSSKSRKRIMPDPVTEPPVTDPVYEALLYCNIPSVAERSMEGHAPHHFKLVSVHVFIRHGDRYPLYVIPKTKRPEIDCTLVANRKPYHPKLEAFISHMSKGSGASFESPLNSLPLYPNHPLCEMGELTQTGVVQHLQNGQLLRDIYLKKHKLLPNDWSADQLYLETTGKSRTLQSGLALLYGFLPDFDWKKIYFRHQPSALFCSGSCYCPVRNQYLEKEQRRQYLLRLKNSQLEKTYGEMAKIVDVPTKQLRAANPIDSMLCHFCHNVSFPCTRNGCVDMEHFKVIKTHQIEDERERREKKLYFGYSLLGAHPILNQTIGRMQRATEGRKEELFALYSAHDVTLSPVLSALGLSEARFPRFAARLIFELWQDREKPSEHSVRILYNGVDVTFHTSFCQDHHKRSPKPMCPLENLVRFVKRDMFVALGGSGTNYYDACHREGF
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
function
FUNCTION: Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. {ECO:0000269|PubMed:24425863}.
uniprot
proteins
mass_dalton
55240
uniprot
proteins
protein_family
Histidine acid phosphatase family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24425863
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:24425863}; Single-pass type II membrane protein {ECO:0000255}. Note=Colocalizes to Golgi apparatus in a B3GAT3-dependent manner. {ECO:0000269|PubMed:24425863}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins