GPAT4
entrez
137964
canonical
uniprot
Q86UL3
canonical
ensembl
ENSG00000158669
resolver
ensp
ENSP00000380184
resolver
ensp
ENSP00000533353
resolver
ensp
ENSP00000533356
resolver
ensp
ENSP00000533358
resolver
ensp
ENSP00000533359
resolver
ensp
ENSP00000606486
resolver
ensp
ENSP00000606487
resolver
ensp
ENSP00000624617
resolver
ensp
ENSP00000624619
resolver
ensp
ENSP00000624620
resolver
enst
ENST00000396987
resolver
enst
ENST00000863294
resolver
enst
ENST00000863297
resolver
enst
ENST00000863299
resolver
enst
ENST00000863300
resolver
enst
ENST00000936427
resolver
enst
ENST00000936428
resolver
enst
ENST00000954558
resolver
enst
ENST00000954560
resolver
enst
ENST00000954561
resolver
genesymbol
GPAT4
resolver
genesymbol_syn
AGPAT6
resolver
genesymbol_syn
TSARG7
resolver
hgnc
HGNC:20880
resolver
uniprot
Q2TU73
resolver
uniprot
Q86V89
resolver
uniprot_entry
GPAT4_HUMAN
resolver
uniprot_sec
Q2TU73
resolver
uniprot_sec
Q86V89
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethylmaleimide (NEM). {ECO:0000269|PubMed:18238778}.
uniprot
proteins
amino_acid_sequence
MFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYMKSLLKIFAWATLRMERGAKEKNHQLYKPYTNGIIAKDPTSLEEEIKEIRRSGSSKALDNTPEFELSDIFYFCRKGMETIMDDEVTKRFSAEELESWNLLSRTNYNFQYISLRLTVLWGLGVLIRYCFLLPLRIALAFTGISLLVVGTTVVGYLPNGRFKEFMSKHVHLMCYRICVRALTAIITYHDRENRPRNGGICVANHTSPIDVIILASDGYYAMVGQVHGGLMGVIQRAMVKACPHVWFERSEVKDRHLVAKRLTEHVQDKSKLPILIFPEGTCINNTSVMMFKKGSFEIGATVYPVAIKYDPQFGDAFWNSSKYGMVTYLLRMMTSWAIVCSVWYLPPMTREADEDAVQFANRVKSAIARQGGLVDLLWDGGLKREKVKDTFKEEQQKLYSKMIVGNHKDRSRS
uniprot
proteins
ec_number
2.3.1.15
uniprot
proteins
function
FUNCTION: Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:18238778). Active against both saturated and unsaturated long-chain fatty acyl-CoAs (PubMed:18238778). Protects cells against lipotoxicity (PubMed:30846318). {ECO:0000269|PubMed:18238778, ECO:0000269|PubMed:30846318}.
uniprot
proteins
mass_dalton
52071
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.
uniprot
proteins
protein_family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
uniprot
proteins
pubmed
12938015
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625827
uniprot
proteins
pubmed
18238778
uniprot
proteins
pubmed
30846318
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18238778}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 156..176; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 180..200; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins