Mmp21
entrez
214766
canonical
uniprot
Q8K3F2
canonical
ensembl
ENSMUSG00000030981
resolver
ensp
ENSMUSP00000033278
resolver
ensp
ENSMUSP00000113853
resolver
enst
ENSMUST00000033278
resolver
enst
ENSMUST00000122136
resolver
genesymbol
Mmp21
resolver
uniprot
F7D2U6
resolver
uniprot
Q3KP73
resolver
uniprot
Q3KP74
resolver
uniprot_entry
F7D2U6_MOUSE
resolver
uniprot_entry
MMP21_MOUSE
resolver
uniprot_entry
Q3KP73_MOUSE
resolver
uniprot_entry
Q3KP74_MOUSE
resolver
amino_acid_sequence
MLAASVLRLTLPLCWLVAPQPTQPERLFHSRDRSDLEPSPLSQAKPIADLHDAQSFLLKYGWSEIPSPKESAGVPVGFTLAQAVRRFQKANRLPASGELDSPTLAAMNKPRCGVPDTRLPPRAALPTPPALLTSLGLRPRARQKRFLQMLFPKPDGQQEDASDTGASRAFSKKTLTWRLVGDAYSSQLSGDEQRYIFRLAFRMWSEVTPLDFREDRTAPGTMVDIKLGFGRGRHLGCPRVFDGSGQEFAHAWRLGEIHFDDDEHFTPLSSDTGISLLKVAVHEIGHVLGLPHTYRVGSIMQPNYIPQEPAFELDWADRKAIQRLYGSCKGSFDTVFDWIRKERNQYGEVRVRFNTYFFRNSWYWLYENRNNRTRYGDPLQILTGWRGIPTQSIDAYVHVWSWGKDERYFFKGSQYWRYDSENDQAHTEDEQGRSYPKLISEGFPGIPSPLDTAFYDRRQQLIYFFKESLVFAFDVNRNQVLNSYPKKMSQVFPAIMPQNHPFRNLDSAYYSYAHNSIFFFKGNSYWKVVSDKDKQQNTRLPLNGLFPKKPVSEKWFDVCDVHTSTLNM
uniprot
proteins
ec_number
3.4.24.-
uniprot
proteins
function
FUNCTION: Plays a specialized role in the generation of left-right asymmetry during embryogenesis (PubMed:26437028). May act as a negative regulator of the NOTCH-signaling pathway. Cleaves alpha-1-antitrypsin (By similarity). {ECO:0000250|UniProtKB:Q8N119, ECO:0000269|PubMed:26437028, ECO:0000269|PubMed:26437029}.
uniprot
proteins
mass_dalton
65454
uniprot
proteins
mutagenesis
MUTAGEN 177; /note="W->L: Miri mutant, animals exhibit visceral heterotaxy, with heart defects commonly associated with heterotaxy."; /evidence="ECO:0000269|PubMed:26437029"; MUTAGEN 225; /note="I->T: Embryos have congenital heart defects with transposition of the great artery, 61% exhibiting situs inversus or heterotaxy and 39% exhibiting situs solitus. This mutation corresponds to the pathological variant 'T-226' identified in humans."; /evidence="ECO:0000269|PubMed:26437028"; MUTAGEN 325; /note="Y->N: Koli mutant, animals exhibit visceral heterotaxy, with heart defects commonly associated with heterotaxy."; /evidence="ECO:0000269|PubMed:26437029
uniprot
proteins
post_translational_modification
PTM: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.
uniprot
proteins
protein_family
Peptidase M10A family
uniprot
proteins
pubmed
12617721
uniprot
proteins
pubmed
26437028
uniprot
proteins
pubmed
26437029
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins