CFL1
entrez
1072
canonical
uniprot
P23528
canonical
ensembl
ENSG00000172757
resolver
ensp
ENSP00000309629
resolver
ensp
ENSP00000432660
resolver
enst
ENST00000308162
resolver
enst
ENST00000525451
resolver
genesymbol
CFL1
resolver
genesymbol
HEL-S-15
resolver
genesymbol_syn
CFL
resolver
hgnc
HGNC:1874
resolver
uniprot
B3KUQ1
resolver
uniprot
Q53Y87
resolver
uniprot
Q9UCA2
resolver
uniprot
V9HWI5
resolver
uniprot_entry
COF1_HUMAN
resolver
uniprot_entry
V9HWI5_HUMAN
resolver
uniprot_sec
B3KUQ1
resolver
uniprot_sec
Q53Y87
resolver
uniprot_sec
Q9UCA2
resolver
amino_acid_sequence
MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
uniprot
proteins
function
FUNCTION: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157, PubMed:33670794). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity). {ECO:0000250|UniProtKB:P18760, ECO:0000269|PubMed:11812157, ECO:0000269|PubMed:15580268, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:33670794}.
uniprot
proteins
mass_dalton
18502
uniprot
proteins
post_translational_modification
PTM: Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2. {ECO:0000250|UniProtKB:P45695, ECO:0000269|PubMed:12837278, ECO:0000269|PubMed:23633677}.
uniprot
proteins
protein_family
Actin-binding proteins ADF family
uniprot
proteins
pubmed
11812157
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12837278
uniprot
proteins
pubmed
14627701
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15580268
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16548883
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21834987
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
2263493
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23633677
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25556234
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
30550596
uniprot
proteins
pubmed
33670794
uniprot
proteins
pubmed
39390519
uniprot
proteins
pubmed
7552146
uniprot
proteins
pubmed
8037689
uniprot
proteins
pubmed
8800436
uniprot
proteins
sequence_length
166
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium {ECO:0000269|PubMed:33670794}. Cell projection, growth cone {ECO:0000250|UniProtKB:P18760}. Cell projection, axon {ECO:0000250|UniProtKB:P18760}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
uniprot
proteins