Tpp1
entrez
83534
canonical
uniprot
Q9EQV6
canonical
ensembl
ENSRNOG00000019212
resolver
ensp
ENSRNOP00000026280
resolver
genesymbol
Tpp1
resolver
genesymbol_syn
Cln2
resolver
uniprot
Q642E6
resolver
uniprot_entry
Q642E6_RAT
resolver
uniprot_entry
TPP1_RAT
resolver
amino_acid_sequence
MGLQARFLGLLALVIAGKCTHSPEPDQRWMLPPGWVSLGRVDPEEELSLTFALKQQNLDRLSELVQAVSDPSSPRYGKYLTLEDVAELVQPSPLTLRTVQKWLLAAGARDCHSVTTQDFLTCWLSVRQAELLLPGAEFHRYVGGPAKTHIIRSPHPYQLPQALAPHVDLVAGLHRFPPLSSPRQRPEPQGVGPVGLHLGVTPSVLRQRYNLTARDVGSGTTNNSQACAQFLEQYFHNSDLTEFMRLFGSSFAHQASVARVVGKQGRGRAGIEASLDVEYLMSAGANISTWVYSSPGRHEAQEPFLQWLLLLSNESSLPHVHTVSYGDDEDSLSSVYIQRVNTEFMKAAARGLTLLFASGDTGAGCWSVSGRHKFRPSFPASSPYVTTVGGTSFKNPFLVTNEVVDYISGGGFSNVFPQPSYQEEAVAQFLKSSSHLPPSSYFNASGRAYPDVAALSDGYWVVSNMVPIPWVSGTSASTPVFGGILSLINEHRLLNGRPPLGFLNPRLYQQHGAGLFDVTHGCHESCLNEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP
uniprot
proteins
ec_number
3.4.14.9
uniprot
proteins
function
FUNCTION: Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus. {ECO:0000269|PubMed:9659384}.
uniprot
proteins
mass_dalton
61332
uniprot
proteins
post_translational_modification
PTM: Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity (By similarity). {ECO:0000250|UniProtKB:O14773}.
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
9659384
uniprot
proteins
sequence_length
563
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:O14773}. Melanosome {ECO:0000250|UniProtKB:O14773}.
uniprot
proteins