Terb2
entrez
74401
canonical
uniprot
Q9D494
canonical
ensembl
ENSMUSG00000027229
resolver
ensp
ENSMUSP00000028661
resolver
enst
ENSMUST00000028661
resolver
genesymbol
Terb2
resolver
genesymbol_syn
4933406J08Rik
resolver
genesymbol_syn
TERB2
resolver
uniprot
A0A0P0YTB2
resolver
uniprot_entry
A0A0P0YTB2_MOUSE
resolver
uniprot_entry
TERB2_MOUSE
resolver
amino_acid_sequence
MFQGQRGWFCGSVSQDLRQIWEDEGGMVSDVKAADFLFSCDASHPDTLRIYQSLEYIEDNATVFHAYYLAAIANTEMKNSVALGHFVLPPACLQKEIRRKIGSFIWEQDEKFQIEKHDRMASSDKENIRPTPEHKQELSKSAEHHLTRTPVIEKQMCFPLHSYPVNNMVTGYISIDALEKFLGELHDFTPGSSGYLAYHIQDEINMSAIKNKLRRKLS
uniprot
proteins
function
FUNCTION: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. {ECO:0000269|PubMed:26548954}.
uniprot
proteins
mass_dalton
25030
uniprot
proteins
protein_family
TERB2 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
26548954
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome, telomere {ECO:0000269|PubMed:26548954}. Nucleus inner membrane {ECO:0000269|PubMed:26548954}. Note=Localizes to telomeres throughout meiotic prophase I and disappears in metaphase I. In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane. {ECO:0000269|PubMed:26548954}.
uniprot
proteins