Slc25a10
entrez
170943
canonical
uniprot
O89035
canonical
ensembl
ENSRNOG00000036693
resolver
ensembl
ENSRNOG00055032397
resolver
ensembl
ENSRNOG00060031161
resolver
ensembl
ENSRNOG00065003903
resolver
ensp
ENSRNOP00000051846
resolver
ensp
ENSRNOP00000078001
resolver
ensp
ENSRNOP00055046113
resolver
ensp
ENSRNOP00060044905
resolver
ensp
ENSRNOP00065004128
resolver
enst
ENSRNOT00000054963
resolver
enst
ENSRNOT00000106118
resolver
enst
ENSRNOT00055055956
resolver
enst
ENSRNOT00060054141
resolver
enst
ENSRNOT00065005726
resolver
genesymbol
Slc25a10
resolver
uniprot
A0A8I5Y824
resolver
uniprot_entry
A0A8I5Y824_RAT
resolver
uniprot_entry
DIC_RAT
resolver
amino_acid_sequence
MAEARTSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALQVVRTDGFLALYNGLSASLCRQMTYSLTRFAIYETMRDYMTKDSQGPLPFYSKVLLGGISGLTGGFVGTPADLVNVRMQNDMKLPLSQRRNYSHALDGLYRVAREEGLKKLFSGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFLSSFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETAKLGPQAFFKGLVPAGVRLVPHTVLTFMFLEQLRKHFGIKVAT
uniprot
proteins
function
FUNCTION: Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across the mitochondrial inner membrane (PubMed:29211846, PubMed:3355813, PubMed:9733776). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (By similarity). Does not transport glutathione (By similarity). Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes (PubMed:9733776). Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (By similarity). {ECO:0000250|UniProtKB:Q06143, ECO:0000250|UniProtKB:Q9QZD8, ECO:0000250|UniProtKB:Q9UBX3, ECO:0000269|PubMed:29211846, ECO:0000269|PubMed:3355813, ECO:0000269|PubMed:9733776}.
uniprot
proteins
mass_dalton
31455
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15632090
uniprot
proteins
pubmed
29211846
uniprot
proteins
pubmed
3355813
uniprot
proteins
pubmed
8985166
uniprot
proteins
pubmed
9733776
uniprot
proteins
sequence_length
286
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:3355813}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 62..81; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 162..181; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 254..274; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins