IST1
entrez
9798
canonical
uniprot
P53990
canonical
ensembl
ENSG00000182149
resolver
ensp
ENSP00000330408
resolver
ensp
ENSP00000368075
resolver
ensp
ENSP00000368076
resolver
ensp
ENSP00000438399
resolver
ensp
ENSP00000463711
resolver
ensp
ENSP00000475853
resolver
genesymbol
IST1
resolver
genesymbol_syn
KIAA0174
resolver
hgnc
HGNC:28977
resolver
uniprot
A8KAH5
resolver
uniprot
B4DXC9
resolver
uniprot
J3QLU7
resolver
uniprot
Q3SYM4
resolver
uniprot
Q9BQ81
resolver
uniprot
Q9BWN2
resolver
uniprot_entry
B4DXC9_HUMAN
resolver
uniprot_entry
IST1_HUMAN
resolver
uniprot_sec
A8KAH5
resolver
uniprot_sec
J3QLU7
resolver
uniprot_sec
Q3SYM4
resolver
uniprot_sec
Q9BQ81
resolver
uniprot_sec
Q9BWN2
resolver
amino_acid_sequence
MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPSANTPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQIVGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT
uniprot
proteins
function
FUNCTION: ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692). Is required for efficient abscission during cytokinesis (PubMed:19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}.
uniprot
proteins
mass_dalton
39751
uniprot
proteins
mutagenesis
MUTAGEN 323; /note="L->D: Diminishes interaction with VPS4A. Greatly diminishes interaction with VPS4A; when associated with A-353."; /evidence="ECO:0000269|PubMed:19129479"; MUTAGEN 326; /note="L->D: Diminishes interaction with VPS4A. Greatly diminishes interaction with VPS4A and abolishes interaction with VTA1; when associated with A-353. Greatly diminishes interaction with VPS4A; when associated with A-360."; /evidence="ECO:0000269|PubMed:19129479"; MUTAGEN 353; /note="L->A: Diminishes interaction with VPS4A. Greatly diminishes interaction with VPS4A and abolishes interaction with VTA1; when associated with D-326. Greatly diminishes interaction with VPS4A; when associated with D-323."; /evidence="ECO:0000269|PubMed:19129479"; MUTAGEN 360..361; /note="LK->AA: Abolishes interaction with VTA1, MITD1 and USP8; diminishes interaction with VPS4A."; /evidence="ECO:0000269|PubMed:19129480"; MUTAGEN 360; /note="L->A: Diminishes interaction with VPS4A. Greatly diminishes interaction with VPS4A; when associated with D-326."; /evidence="ECO:0000269|PubMed:19129479
uniprot
proteins
protein_family
IST1 family
uniprot
proteins
pubmed
12761501
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
19129479
uniprot
proteins
pubmed
19129480
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20719964
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23015756
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23897888
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26040712
uniprot
proteins
pubmed
28242692
uniprot
proteins
pubmed
8724849
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20719964}. Midbody {ECO:0000269|PubMed:20719964}. Nucleus envelope {ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}. Note=Localizes to centrosome and midbody of dividing cells (PubMed:19129479, PubMed:19129480, PubMed:20719964). Colocalized with SPART to the ends of Flemming bodies during cytokinesis (PubMed:20719964). Localizes to the reforming nuclear envelope on chromatin disks during late anaphase. {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:20719964, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}.
uniprot
proteins