RAMP3
entrez
10268
canonical
uniprot
O60896
canonical
ensembl
ENSG00000122679
resolver
ensp
ENSP00000242249
resolver
ensp
ENSP00000419012
resolver
ensp
ENSP00000550797
resolver
enst
ENST00000242249
resolver
enst
ENST00000481345
resolver
genesymbol
RAMP3
resolver
hgnc
HGNC:9845
resolver
uniprot
A4D2L1
resolver
uniprot
Q7Z2Y1
resolver
uniprot_entry
A4D2L1_HUMAN
resolver
uniprot_entry
RAMP3_HUMAN
resolver
uniprot_sec
Q7Z2Y1
resolver
amino_acid_sequence
METGALRRPQLLPLLLLLCGGCPRAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKRTDTLL
uniprot
proteins
function
FUNCTION: Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G protein-coupled estrogen receptor 1 (GPER1) (PubMed:23674134, PubMed:9620797). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane (PubMed:23674134, PubMed:9620797). Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner (PubMed:23674134). Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2 (PubMed:32296767). Together with CALCR, act as a receptor complex for amylin/IAPP (PubMed:35324283). {ECO:0000269|PubMed:23674134, ECO:0000269|PubMed:32296767, ECO:0000269|PubMed:35324283, ECO:0000269|PubMed:9620797}.
uniprot
proteins
mass_dalton
16518
uniprot
proteins
protein_family
RAMP family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23674134
uniprot
proteins
pubmed
32296767
uniprot
proteins
pubmed
35324283
uniprot
proteins
pubmed
9620797
uniprot
proteins
sequence_length
148
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23674134, ECO:0000269|PubMed:32296767}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134, ECO:0000269|PubMed:32296767}. Membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.
uniprot
proteins
transmembrane_region
TRANSMEM 114..138; /note="Helical"; /evidence="ECO:0000269|PubMed:32296767, ECO:0007744|PDB:6UVA
uniprot
proteins