RPRD1B
entrez
58490
canonical
uniprot
Q9NQG5
canonical
ensembl
ENSG00000101413
resolver
ensp
ENSP00000362532
resolver
ensp
ENSP00000416420
resolver
enst
ENST00000373433
resolver
genesymbol
RPRD1B
resolver
genesymbol_syn
C20orf77
resolver
genesymbol_syn
CREPT
resolver
hgnc
HGNC:16209
resolver
uniprot
Q1WDE7
resolver
uniprot
Q6PKF4
resolver
uniprot_entry
RPR1B_HUMAN
resolver
uniprot_sec
Q1WDE7
resolver
uniprot_sec
Q6PKF4
resolver
amino_acid_sequence
MSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSLPDLSLLPNVTGGLAPLPSAGDLFSTD
uniprot
proteins
function
FUNCTION: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}.
uniprot
proteins
mass_dalton
36900
uniprot
proteins
mutagenesis
MUTAGEN 114; /note="R->A: Complete loss of binding to POLR2ACTD in vivo."; /evidence="ECO:0000269|PubMed:24997600
uniprot
proteins
protein_family
UPF0400 (RTT103) family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22231121
uniprot
proteins
pubmed
22264791
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24399136
uniprot
proteins
pubmed
24997600
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791}.
uniprot
proteins