Hrh1
entrez
24448
canonical
uniprot
P31390
canonical
ensembl
ENSRNOG00000007420
resolver
ensp
ENSRNOP00000009775
resolver
ensp
ENSRNOP00000102229
resolver
ensp
ENSRNOP00000103271
resolver
ensp
ENSRNOP00000109554
resolver
ensp
ENSRNOP00000110328
resolver
ensp
ENSRNOP00000111512
resolver
enst
ENSRNOT00000009775
resolver
enst
ENSRNOT00000124731
resolver
enst
ENSRNOT00000135099
resolver
enst
ENSRNOT00000146873
resolver
enst
ENSRNOT00000156547
resolver
enst
ENSRNOT00000164044
resolver
genesymbol
Hrh1
resolver
uniprot
G3V6X5
resolver
uniprot_entry
G3V6X5_RAT
resolver
uniprot_entry
HRH1_RAT
resolver
amino_acid_sequence
MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:7678492). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:7678492}.
uniprot
proteins
mass_dalton
55693
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor down-regulation. {ECO:0000250|UniProtKB:P35367}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7678492
uniprot
proteins
sequence_length
486
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7678492}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P35367}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P35367"; TRANSMEM 65..89; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P35367"; TRANSMEM 98..123; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P35367"; TRANSMEM 145..164; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P35367"; TRANSMEM 189..211; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P35367"; TRANSMEM 416..439; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P35367"; TRANSMEM 446..468; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P35367
uniprot
proteins