GREM2
entrez
64388
canonical
uniprot
Q9H772
canonical
ensembl
ENSG00000180875
resolver
ensp
ENSP00000318650
resolver
ensp
ENSP00000529963
resolver
ensp
ENSP00000529964
resolver
ensp
ENSP00000529965
resolver
ensp
ENSP00000612476
resolver
enst
ENST00000318160
resolver
enst
ENST00000859904
resolver
enst
ENST00000859905
resolver
enst
ENST00000859906
resolver
enst
ENST00000942417
resolver
genesymbol
GREM2
resolver
genesymbol_syn
CKTSF1B2
resolver
genesymbol_syn
DAND3
resolver
genesymbol_syn
PRDC
resolver
hgnc
HGNC:17655
resolver
uniprot
Q86UD9
resolver
uniprot_entry
GREM2_HUMAN
resolver
uniprot_sec
Q86UD9
resolver
amino_acid_sequence
MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ
uniprot
proteins
disease_involvement
DISEASE: Tooth agenesis, selective, 9 (STHAG9) [MIM:617275]: A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). STHAG9 inheritance is autosomal dominant. {ECO:0000269|PubMed:26416033}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells. {ECO:0000250|UniProtKB:O88273}.
uniprot
proteins
mass_dalton
19320
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:O88273}.
uniprot
proteins
protein_family
DAN family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15254711
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
26416033
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins