KCNH7
entrez
90134
canonical
uniprot
Q9NS40
canonical
ensembl
ENSG00000184611
resolver
ensp
ENSP00000331727
resolver
ensp
ENSP00000333781
resolver
genesymbol
KCNH7
resolver
genesymbol_syn
ERG3
resolver
hgnc
HGNC:18863
resolver
uniprot
Q53QU4
resolver
uniprot
Q53TB7
resolver
uniprot
Q53TP9
resolver
uniprot
Q8IV15
resolver
uniprot_entry
KCNH7_HUMAN
resolver
uniprot_sec
Q53QU4
resolver
uniprot_sec
Q53TB7
resolver
uniprot_sec
Q53TP9
resolver
uniprot_sec
Q8IV15
resolver
activity_regulation
ACTIVITY REGULATION: Heme inhibits voltage-gated inwardly rectifying potassium channel activity. {ECO:0000269|PubMed:32723862}.
uniprot
proteins
amino_acid_sequence
MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAMMFIINFEYVTDNENAATPERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSLPQEDPDVVVIDSSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSKCSPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGFGVHPKNIFRDRHASEDNGRNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFNLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESEGEKENSTNDPEDSADTIRHYQSSKRHFEEKKSRSSSFISSIDDEQKPLFSGIVDSSPGIGKASGLDFEETVPTSGRMHIDKRSHSCKDITDMRSWERENAHPQPEDSSPSALQRAAWGISETESDLTYGEVEQRLDLLQEQLNRLESQMTTDIQTILQLLQKQTTVVPPAYSMVTAGSEYQRPIIQLMRTSQPEASIKTDRSFSPSSQCPEFLDLEKSKLKSKESLSSGVHLNTASEDNLTSLLKQDSDLSLELHLRQRKTYVHPIRHPSLPDSSLSTVGIVGLHRHVSDPGLPGK
uniprot
proteins
function
FUNCTION: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed:32723862). Exhibits faster activation and deactivation kinetics and slow inactivation at membrane potentials positive to 240 mV, resulting in the weakest inward rectification (PubMed:32723862). {ECO:0000269|PubMed:32723862}.
uniprot
proteins
mass_dalton
135000
uniprot
proteins
protein_family
H (Eag) (TC 1.A.1.20) subfamily
uniprot
proteins
protein_family
Kv11.3/KCNH7 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
12634931
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
32723862
uniprot
proteins
sequence_length
1196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q12809}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12809}.
uniprot
proteins
transmembrane_region
TRANSMEM 413..433; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 450..470; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 495..515; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 522..542; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 550..570; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 642..662; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins