Gnpda2
entrez
67980
canonical
uniprot
Q9CRC9
canonical
ensembl
ENSMUSG00000029209
resolver
ensp
ENSMUSP00000031117
resolver
ensp
ENSMUSP00000112484
resolver
ensp
ENSMUSP00000133490
resolver
ensp
ENSMUSP00000169561
resolver
enst
ENSMUST00000120789
resolver
genesymbol
Gnpda2
resolver
genesymbol_syn
Kiaa4008
resolver
uniprot
D3YWR1
resolver
uniprot
Q3TH02
resolver
uniprot
Q9D457
resolver
uniprot_entry
D3YWR1_MOUSE
resolver
uniprot_entry
GNPI2_MOUSE
resolver
uniprot_sec
Q3TH02
resolver
uniprot_sec
Q9D457
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by N-acetylglucosamine-6-phosphate (GlcNAc6P). {ECO:0000250|UniProtKB:Q8TDQ7}.
uniprot
proteins
amino_acid_sequence
MRLVILDNYDLASEWAAKYICNRIIKFKPGQDRYFSLGLPTGSTPLGCYKKLIEYHKSGNLSFKYVKTFNMDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFEEKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAMEEGVNHMWTVSAFQQHPRTIFVCDEDATLELRVKTVKYFKGLMHVHNKLVDPLYSMKEGN
uniprot
proteins
ec_number
3.5.99.6
uniprot
proteins
function
FUNCTION: Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. {ECO:0000250|UniProtKB:Q8TDQ7}.
uniprot
proteins
mass_dalton
31084
uniprot
proteins
pathway_participation
PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1. {ECO:0000250|UniProtKB:Q8TDQ7}.
uniprot
proteins
protein_family
Glucosamine/galactosamine-6-phosphate isomerase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins