Ticam1
entrez
106759
canonical
uniprot
Q80UF7
canonical
ensembl
ENSMUSG00000047123
resolver
ensp
ENSMUSP00000055104
resolver
enst
ENSMUST00000058136
resolver
genesymbol
Ticam1
resolver
genesymbol_syn
Trif
resolver
uniprot
Q3UDB7
resolver
uniprot
Q3UP66
resolver
uniprot
Q6P6J2
resolver
uniprot
Q8CIB7
resolver
uniprot
Q8JZV0
resolver
uniprot_entry
TCAM1_MOUSE
resolver
uniprot_sec
Q3UDB7
resolver
uniprot_sec
Q3UP66
resolver
uniprot_sec
Q6P6J2
resolver
uniprot_sec
Q8CIB7
resolver
uniprot_sec
Q8JZV0
resolver
amino_acid_sequence
MDNPGPSLRGAFGILGALERDRLTHLKHKLGSLCSGSQESKLLHAMVLLALGQDTEARVSLESLKMNTVAQLVAHQWADMETTEGPEEPPDLSWTVARLYHLLAEENLCPASTRDMAYQVALRDFASQGDHQLGQLQNEAWDRCSSDIKGDPSGFQPLHSHQGSLQPPSASPAVTRSQPRPIDTPDWSWGHTLHSTNSTASLASHLEISQSPTLAFLSSHHGTHGPSKLCNTPLDTQEPQLVPEGCQEPEEISWPPSVETSVSLGLPHEISVPEVSPEEASPILPDALAAPDTSVHCPIECTELSTNSRSPLTSTTESVGKQWPITSQRSPQVPVGDDSLQNTTSSSPPAQPPSLQASPKLPPSPLSSASSPSSYPAPPTSTSPVLDHSETSDQKFYNFVVIHARADEQVALRIREKLETLGVPDGATFCEEFQVPGRGELHCLQDAIDHSGFTILLLTASFDCSLSLHQINHALMNSLTQSGRQDCVIPLLPLECSQAQLSPDTTRLLHSIVWLDEHSPIFARKVANTFKTQKLQAQRVRWKKAQEARTLKEQSIQLEAERQNVAAISAAYTAYVHSYRAWQAEMNKLGVAFGKNLSLGTPTPSWPGCPQPIPSHPQGGTPVFPYSPQPPSFPQPPCFPQPPSFPQPPSFPLPPVSSPQSQSFPSASSPAPQTPGPQPLIIHHAQMVQLGVNNHMWGHTGAQSSDDKTECSENPCMGPLTDQGEPLLETPE
uniprot
proteins
function
FUNCTION: Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12855817, PubMed:16002681, PubMed:21703541). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12855817, PubMed:16002681, PubMed:21703541). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12855817, PubMed:16002681, PubMed:21703541). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines (PubMed:21703541). {ECO:0000250|UniProtKB:Q8IUC6, ECO:0000269|PubMed:12855817, ECO:0000269|PubMed:16002681, ECO:0000269|PubMed:21703541}.
uniprot
proteins
mass_dalton
79230
uniprot
proteins
mutagenesis
MUTAGEN 228; /note="K->R: Abolished ubiquitination by TRIM38."; /evidence="ECO:0000269|PubMed:26392463"; MUTAGEN 321; /note="K->R: Does not affect ubiquitination by TRIM38."; /evidence="ECO:0000269|PubMed:26392463
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by TBK1. Following activation, phosphorylated by TBK1 at Ser-209 in the pLxIS motif. The phosphorylated pLxIS motif constitutes an IRF3-binding motif, leading to recruitment of the transcription factor IRF3 to induce type-I interferons and other cytokines. {ECO:0000250|UniProtKB:Q8IUC6}.; PTM: Polyubiquitinated at Lys-228 by TRIM38 with 'Lys-48'-linked chains, leading to proteasomal degradation (PubMed:26392463). Polyubiquitinated with 'Lys-6'- and 'Lys-33'-linked chains in a TRIM8-dependent manner; ubiquitination disrupts the interaction with TBK1 and subsequent interferon production (By similarity). Polyubiquitinated with 'Lys-27'-linked chains at Lys-525, promoting TLR3/4-mediated innate immune signaling (By similarity). {ECO:0000250|UniProtKB:Q8IUC6, ECO:0000269|PubMed:26392463}.
uniprot
proteins
pubmed
12539043
uniprot
proteins
pubmed
12855817
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16002681
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16306936
uniprot
proteins
pubmed
17457343
uniprot
proteins
pubmed
18849341
uniprot
proteins
pubmed
21703541
uniprot
proteins
pubmed
25736436
uniprot
proteins
pubmed
26392463
uniprot
proteins
sequence_length
732
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21703541}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q8IUC6}. Mitochondrion {ECO:0000269|PubMed:21703541}. Note=Colocalizes with UBQLN1 in the autophagosome. Colocalizes in the cytosol with DDX1, DDX21 and DHX36 (PubMed:21703541). Colocalizes in the mitochondria with DDX1 and poly(I:C) RNA ligand (PubMed:21703541). The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) RNA ligand stimulation (PubMed:21703541). {ECO:0000250|UniProtKB:Q8IUC6, ECO:0000269|PubMed:21703541}.
uniprot
proteins