Mug1
entrez
497794
canonical
uniprot
Q03626
canonical
ensembl
ENSRNOG00000091232
resolver
ensembl
ENSRNOG00055011345
resolver
ensembl
ENSRNOG00060031936
resolver
ensp
ENSRNOP00000019969
resolver
ensp
ENSRNOP00000069175
resolver
genesymbol
Mug1
resolver
genesymbol_syn
A1i3
resolver
uniprot
Q03310
resolver
uniprot
Q63018
resolver
uniprot
Q63020
resolver
uniprot
Q63023
resolver
uniprot
Q78DZ4
resolver
uniprot
Q9JMK7
resolver
uniprot_entry
MUG1_RAT
resolver
uniprot_sec
Q03310
resolver
uniprot_sec
Q63018
resolver
uniprot_sec
Q63020
resolver
uniprot_sec
Q63023
resolver
uniprot_sec
Q78DZ4
resolver
uniprot_sec
Q9JMK7
resolver
amino_acid_sequence
MKKNREAQLCLFSALLAFLPFASLLNGNSKYMVLVPSQLYTETPEKICLHLYHLNETVTVTASLISQRGTRKLFDELVVDKDLFHCLSFTIPRLPSSEEEESLDINIEGAKHKFSERRVVLVKNKESVVFVQTDKPVYKPGQSVKFRVVSMDKNLHPLNELFPLAYIEDPKMNRIMQWQDIKTENGLKQLSFSLSAEPIQGPYKIVILKQSGVKEEHSFTVMEFVLPRFGVDVKVPNAISVYDEIINVTACAIYTYGKPVPGHVKISLCHGNPSFSSETKSACKEEDSELDNNGCSTQEVNITEFQLKENYLKMHQAFHVNATVTEEGTGSEFSGSGRIEVERTRNKFLFLKADSHFRHGIPFFVKIRLVDIKGDPIPNEQVFIKAQEAGYTNATTTDQHGLAKFSIDTSSISGYSLNIKVYHKEESSCIHSSCTAERHAEEHHTAYAVYSLSKSYIYLDTEAGVLPCNQIHTVQAHFILKGQVLGVLPQIVFHYLVMAQGSILQTGNHTHQVEPGVSQVQGNFALEIPVEFSMVPVAKMLIYTILPDGEVIADSVTFQVEKCLRNKVHLSFSPSQSLPASQTHMRVTASPQSLCGLRAVDQSVLLLKPEAELSPSLIYDLPGMQDSNFIPSSYHPFEDEYDCLMYQPRDTEELTYSVPYGREKDVYRYVRDMGLTAFTNLKIKHPTYCYEMNMVVLSAPAVESELSPRGGEFEMMPLGVNKSPLPKEPPRKDPPPKDPVIETIRNYFPETWIWDLVTVNSSGVTEVEMTVPDTITEWKAGALCLSNDTGLGLSSVATLQAFQPFFVELTMPYSVIRGEAFMLKATVMNYLPTSLPMAVQLEASPDFTAVPVGNDQDSYCLGANGRHTSSWLVTPKSLGNVNFSVSVEAQQSPELCGSQVATVPETGRKDTVVKVLIVEPEGIKKEHTFSSLLCASDAELSETLSLLLPPTVVKDSARAHFSVMGDILSSAIKNTQNLIQMPYGCGEQNMVLFAPNIYVLKYLNETQQLTEKIKSKALGYLRAGYQRELNYKHKDGSYSAFGDHNGQGQGNTWLTAFVLKSFAQARAFIFIDESHITDAFTWLSKQQKDSGCFRSSGSLFNNAMKGGVDDEITLSAYITMALLESSLPDTDPVVSKALGCLEASWETIEQGRNGSFVYTKTLMAYAFALAGNQEKRNEILKSLDKEAIREDNSIHWERPQKPTKSEGYLYTPQASSAEVEMSAYVVLARLTAQPAPSPEDLALSMGTIKWLTKQQNSHGGFSSTQDTVVALDALSKYGAATFSKSQKTPLVTIQSSGSFSQKFQVDNSNRLLLQQVSLPDIPGNYTVSVSGEGCVYAQTTLRYNMPLEKQQPAFALKVQTVPLTCNNPKGQNSFQISLEISYTGSRPASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTEVTTNNVLLYLDQVTNQTLSFSFIIQQDIPVKNLQPAIVKVYDYYETDEVAFAEYSSPCSSDKQNV
uniprot
proteins
function
FUNCTION: A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective. {ECO:0000305}.
uniprot
proteins
mass_dalton
165326
uniprot
proteins
protein_family
Protease inhibitor I39 (alpha-2-macroglobulin) family
uniprot
proteins
pubmed
1709877
uniprot
proteins
pubmed
2511184
uniprot
proteins
pubmed
2831216
uniprot
proteins
sequence_length
1487
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2511184}.
uniprot
proteins