Irag2
entrez
16970
canonical
uniprot
Q60664
canonical
ensembl
ENSMUSG00000030263
resolver
ensp
ENSMUSP00000032396
resolver
ensp
ENSMUSP00000120248
resolver
ensp
ENSMUSP00000280864
resolver
ensp
ENSMUSP00000280865
resolver
enst
ENSMUST00000032396
resolver
genesymbol
Irag2
resolver
genesymbol_syn
Jaw1
resolver
genesymbol_syn
Lrmp
resolver
uniprot
G5E880
resolver
uniprot
Q3TVR1
resolver
uniprot
Q3V3H7
resolver
uniprot
Q7TMU8
resolver
uniprot_entry
G5E880_MOUSE
resolver
uniprot_entry
IRAG2_MOUSE
resolver
uniprot_entry
Q3TVR1_MOUSE
resolver
uniprot_entry
Q3V3H7_MOUSE
resolver
uniprot_sec
Q7TMU8
resolver
amino_acid_sequence
MLCVKGPPEQEPEDGALDVTRGCQCPLPTEDSILGQELLDCTRMNEDQSTDENGAGHFYSESPSQLREYLTQPSSEQTSSSESTVTSSESGSDILHMASGDLDCKPLCEKEEEARAASAMQGTSLAPAAYGDYTSVGVAKAASQLEAGEELRTTENGGKGSAPGETEISMPPKASVKLVNFQQSENTSANEKEVEAEFLRLSLGLKCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPLCEEDNQAQEIVKKLEKSIVLLSQCTARVASRAEMLGAINQESRVSRAVEVMIQHVENLKRMYAKEHAELEDLKQALLQNDRSFNSLPDEDDCQIKKRSSSLNSKPSSLRRVTIASLPRNLGNVGLVSGMENNDRFSRRSSSWRILGTKQGEHRPSLHRFISTYSWADAEDERSDVKARDAPEPQGEEAVERTRKPSLSERRSSTLAWDRGTICSSVASWVTHLQASFRRANRALWLTGLIIILIAALMSFLTGQLFQTAVEAAPTQEGDSWLSLEHILWPFTRLGHDGPPPV
uniprot
proteins
function
FUNCTION: Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion (PubMed:9314557). Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules (PubMed:29878215). Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (PubMed:32647060). {ECO:0000269|PubMed:29878215, ECO:0000269|PubMed:32647060, ECO:0000269|PubMed:9314557}.
uniprot
proteins
mass_dalton
59588
uniprot
proteins
mutagenesis
MUTAGEN 480..539; /note="Missing: Results in cytosolic distribution."; /evidence="ECO:0000269|PubMed:8798562
uniprot
proteins
post_translational_modification
PTM: The removal of the C-terminal lumenal domain occurs by proteolytic processing. {ECO:0000269|PubMed:8798562, ECO:0000269|PubMed:9314557}.
uniprot
proteins
protein_family
IRAG2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20071408
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29878215
uniprot
proteins
pubmed
32647060
uniprot
proteins
pubmed
8021504
uniprot
proteins
pubmed
8798562
uniprot
proteins
pubmed
9314557
uniprot
proteins
sequence_length
539
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Processed inositol 1,4,5-triphosphate receptor associated 2]: Cytoplasm {ECO:0000269|PubMed:8798562}.; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20071408}; Single-pass type IV membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000305|PubMed:29878215}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5RHB5}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q5RHB5}. Chromosome {ECO:0000250|UniProtKB:Q5RHB5}. Note=Colocalized with ITPR3 on the endoplasmic reticulum membrane. {ECO:0000269|PubMed:20071408}.
uniprot
proteins
transmembrane_region
TRANSMEM 480..500; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins