RAB3IP
entrez
117177
canonical
uniprot
Q96QF0
canonical
ensembl
ENSG00000127328
resolver
ensp
ENSP00000247833
resolver
ensp
ENSP00000355381
resolver
ensp
ENSP00000368086
resolver
ensp
ENSP00000419216
resolver
ensp
ENSP00000447300
resolver
ensp
ENSP00000448027
resolver
ensp
ENSP00000448773
resolver
ensp
ENSP00000695574
resolver
ensp
ENSP00000744831
resolver
genesymbol
RAB3IP
resolver
genesymbol_syn
RABIN8
resolver
hgnc
HGNC:16508
resolver
uniprot
B7WPJ6
resolver
uniprot
Q6PCE4
resolver
uniprot
Q96A24
resolver
uniprot
Q96QE6
resolver
uniprot
Q96QE7
resolver
uniprot
Q96QE8
resolver
uniprot
Q96QE9
resolver
uniprot
Q96QF1
resolver
uniprot
Q9H673
resolver
uniprot_entry
RAB3I_HUMAN
resolver
uniprot_sec
B7WPJ6
resolver
uniprot_sec
Q6PCE4
resolver
uniprot_sec
Q96A24
resolver
uniprot_sec
Q96QE6
resolver
uniprot_sec
Q96QE7
resolver
uniprot_sec
Q96QE8
resolver
uniprot_sec
Q96QE9
resolver
uniprot_sec
Q96QF1
resolver
uniprot_sec
Q9H673
resolver
activity_regulation
ACTIVITY REGULATION: Phosphorylation by ATK1 alters its GEF activity (PubMed:31204173). Complex formation with RAB11A and RAB11FIP3 and ciliogenesis function are competitively inhibited by RAB11A-WDR44 interaction (PubMed:31204173). {ECO:0000269|PubMed:31204173}.
uniprot
proteins
amino_acid_sequence
MGLKKMKGLSYDEAFAMANDPLEGFHEVNLASPTSPDLLGVYESGTQEQTTSPSVIYRPHPSALSSVPIQANALDVSELPTQPVYSSPRRLNCAEISSISFHVTDPAPCSTSGVTAGLTKLTTRKDNYNAEREFLQGATITEACDGSDDIFGLSTDSLSRLRSPSVLEVREKGYERLKEELAKAQRELKLKDEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKKGHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEADLSLYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLTFSKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKSCKHRIKLGDSSNYYYISPFCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLRKEMSLAKLGYFKEEL
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879, PubMed:31204173). {ECO:0000269|PubMed:12221131, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:31204173}.
uniprot
proteins
mass_dalton
53021
uniprot
proteins
mutagenesis
MUTAGEN 435; /note="T->A: Reduced complex formation with RAB11A; when associated with A-439 and A-444."; /evidence="ECO:0000269|PubMed:26258637"; MUTAGEN 439; /note="Y->A: Reduced complex formation with RAB11A; when associated with A-435 and A-444."; /evidence="ECO:0000269|PubMed:26258637"; MUTAGEN 444; /note="L->A: Reduced complex formation with RAB11A; when associated with A-435 and A-439."; /evidence="ECO:0000269|PubMed:26258637
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by AKT1; the phosphorylation alters its GEF activity. {ECO:0000269|PubMed:31204173}.
uniprot
proteins
protein_family
SEC2 family
uniprot
proteins
pubmed
12007189
uniprot
proteins
pubmed
12221131
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20890297
uniprot
proteins
pubmed
20937701
uniprot
proteins
pubmed
22159412
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25673879
uniprot
proteins
pubmed
26258637
uniprot
proteins
pubmed
26824392
uniprot
proteins
pubmed
31204173
uniprot
proteins
pubmed
31467083
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12007189, ECO:0000269|PubMed:31467083}. Nucleus {ECO:0000269|PubMed:12007189}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12221131}. Cell projection, lamellipodium. Vesicle {ECO:0000269|PubMed:31467083}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:31467083}. Note=Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. {ECO:0000269|PubMed:12007189}.
uniprot
proteins