Rer1
entrez
67830
canonical
uniprot
Q9CQU3
canonical
ensembl
ENSMUSG00000029048
resolver
ensp
ENSMUSP00000030914
resolver
ensp
ENSMUSP00000244827
resolver
ensp
ENSMUSP00000244836
resolver
ensp
ENSMUSP00000244838
resolver
ensp
ENSMUSP00000244842
resolver
ensp
ENSMUSP00000244847
resolver
ensp
ENSMUSP00000244849
resolver
enst
ENSMUST00000030914
resolver
genesymbol
Rer1
resolver
uniprot
Q3THP4
resolver
uniprot_entry
RER1_MOUSE
resolver
uniprot_sec
Q3THP4
resolver
amino_acid_sequence
MSEGDSVGDSVHGKPSVVYRFFSRLGQIYQSWLDKSTPYTAVRWVVTLGLSFVYMIRVYLLQGWYIVTYALGIYHLNLFIAFLSPKVDPSLMEDSDDGPSLPTKQNEEFRPFIRRLPEFKFWHAATKGILVAMICTFFEAFNVPVFWPILVMYFIMLFCITMKRQIKHMIKYRYIPFTHGKRRYKGKEDVGKTFAS
uniprot
proteins
function
FUNCTION: Involved in the retention or retrieval of proteins localized in the endoplasmic reticulum from the early Golgi compartment, including the gamma-secretase complex subunit PEN-2 (PSENEN) (By similarity). Regulates intracellular trafficking of the gamma-secretase complex and amyloid-beta precursor protein (APP), thereby controlling their levels at the cell surface and influencing the release of amyloid-beta peptides generated through gamma-secretase mediated processing of APP (By similarity). During cerebral cortex and neural stem cell development, it is required to maintain sufficient expression and activity of gamma-secretase complex at the cell surface, modulating NOTCH processing and signaling (PubMed:30260951). In addition to its role in the control of protein trafficking, the RER1-dependent Golgi apparatus-endoplasmic reticulum retrieval system may regulate proteasomal degradation of alpha-synuclein (SNCA) (By similarity). {ECO:0000250|UniProtKB:O15258, ECO:0000269|PubMed:30260951}.
uniprot
proteins
mass_dalton
22988
uniprot
proteins
protein_family
RER1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30260951
uniprot
proteins
sequence_length
196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:O15258}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:O15258}.
uniprot
proteins
transmembrane_region
TRANSMEM 41..61; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 63..83; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins