MAP3K2
entrez
10746
canonical
uniprot
Q9Y2U5
canonical
ensembl
ENSG00000169967
resolver
ensp
ENSP00000343463
resolver
ensp
ENSP00000387246
resolver
ensp
ENSP00000507315
resolver
ensp
ENSP00000552681
resolver
ensp
ENSP00000552683
resolver
ensp
ENSP00000552684
resolver
ensp
ENSP00000552685
resolver
ensp
ENSP00000552686
resolver
ensp
ENSP00000552687
resolver
ensp
ENSP00000552688
resolver
enst
ENST00000344908
resolver
enst
ENST00000409947
resolver
enst
ENST00000682094
resolver
enst
ENST00000882622
resolver
enst
ENST00000882624
resolver
enst
ENST00000882625
resolver
enst
ENST00000882626
resolver
enst
ENST00000882627
resolver
enst
ENST00000882628
resolver
enst
ENST00000882629
resolver
genesymbol
MAP3K2
resolver
genesymbol_syn
MAPKKK2
resolver
genesymbol_syn
MEKK2
resolver
hgnc
HGNC:6854
resolver
uniprot
B9EG87
resolver
uniprot
Q53QL9
resolver
uniprot
Q53S75
resolver
uniprot
Q59GZ6
resolver
uniprot
Q8NC32
resolver
uniprot
Q9NYK3
resolver
uniprot_entry
M3K2_HUMAN
resolver
uniprot_sec
B9EG87
resolver
uniprot_sec
Q53QL9
resolver
uniprot_sec
Q53S75
resolver
uniprot_sec
Q59GZ6
resolver
uniprot_sec
Q8NC32
resolver
uniprot_sec
Q9NYK3
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-524. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSADELLRHMFVHYH
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}.
uniprot
proteins
mass_dalton
69741
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000250}.; PTM: Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation. {ECO:0000269|PubMed:18761086}.
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
10713157
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15075238
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16001074
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17906693
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18761086
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
619
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15075238}. Nucleus {ECO:0000269|PubMed:15075238}. Note=Upon EGF stimulation, translocates into the nucleus.
uniprot
proteins