Hand2
entrez
64637
canonical
uniprot
P61295
canonical
ensembl
ENSRNOG00000060448
resolver
ensembl
ENSRNOG00055012257
resolver
ensembl
ENSRNOG00060007290
resolver
ensembl
ENSRNOG00065004432
resolver
ensp
ENSRNOP00000074299
resolver
ensp
ENSRNOP00055016828
resolver
ensp
ENSRNOP00060009026
resolver
ensp
ENSRNOP00065004534
resolver
enst
ENSRNOT00000079552
resolver
enst
ENSRNOT00055020850
resolver
enst
ENSRNOT00060011981
resolver
enst
ENSRNOT00065006452
resolver
genesymbol
Hand2
resolver
genesymbol_syn
Dhand
resolver
uniprot
O95300
resolver
uniprot
O95301
resolver
uniprot
P97833
resolver
uniprot_entry
HAND2_RAT
resolver
uniprot_sec
O95300
resolver
uniprot_sec
O95301
resolver
uniprot_sec
P97833
resolver
amino_acid_sequence
MSLVGGFPHHPVVHHEGYPFAAAAAAAAAAAASRCSHEENPYFHGWLIGHPEMSPPDYSMALSYSPEYASGAAGLDHSHYGGVPPGAGPPGLGGPRPVKRRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQNGEAEAFKAEIKKTDVKEEKRKKELNEILKSTVSSNDKKTKGRTGWPQHVWALELKQ
uniprot
proteins
function
FUNCTION: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
23666
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
uniprot
proteins