Ppif
entrez
282819
canonical
uniprot
P29117
canonical
ensembl
ENSRNOG00000010558
resolver
ensembl
ENSRNOG00055021582
resolver
ensembl
ENSRNOG00060013231
resolver
ensembl
ENSRNOG00065015119
resolver
ensp
ENSRNOP00000085863
resolver
ensp
ENSRNOP00055029994
resolver
ensp
ENSRNOP00060017872
resolver
ensp
ENSRNOP00065019589
resolver
enst
ENSRNOT00000106999
resolver
enst
ENSRNOT00055036906
resolver
enst
ENSRNOT00060022551
resolver
enst
ENSRNOT00065025031
resolver
genesymbol
Ppif
resolver
uniprot_entry
PPIF_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Binds cyclosporin A (CsA). Is displaced by CsA from the mPTP leading to a lower open probability of the mPTP. {ECO:0000250|UniProtKB:P30405}.
uniprot
proteins
amino_acid_sequence
MLALRCGPRLLGLLSGPRSAPLLLSTTRTCSDGGARGANSSSQNPLVYLDVGADGQPLGRVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPAFMCQAGDFTNHNGTGGKSIYGSRFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIKTDWLDGKHVVFGHVKEGMDVVKKIESFGSKSGKTSKKIVITDCGQLS
uniprot
proteins
ec_number
5.2.1.8
uniprot
proteins
function
FUNCTION: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (By similarity). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:8567677, PubMed:9309684, PubMed:9820802). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:8567677, PubMed:9309684, PubMed:9820802). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:8567677, PubMed:9309684, PubMed:9820802). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (PubMed:8567677, PubMed:9309684, PubMed:9820802). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691). {ECO:0000250|UniProtKB:P30405, ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:8567677, ECO:0000269|PubMed:9309684, ECO:0000269|PubMed:9820802}.
uniprot
proteins
mass_dalton
21810
uniprot
proteins
post_translational_modification
PTM: Acetylated at Lys-166; deacetylated at Lys-166 by SIRT3. {ECO:0000250|UniProtKB:Q99KR7}.; PTM: Benzoylated at Lys-72 and Lys-196. Debenzoylated by SIRT3; inhibiting its cooperation with p53/TP53. {ECO:0000250|UniProtKB:P30405}.
uniprot
proteins
protein_family
Cyclophilin-type PPIase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1599421
uniprot
proteins
pubmed
18667415
uniprot
proteins
pubmed
19228691
uniprot
proteins
pubmed
8567677
uniprot
proteins
pubmed
9309684
uniprot
proteins
pubmed
9820802
uniprot
proteins
pubmed
9874241
uniprot
proteins
sequence_length
206
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:8567677}.
uniprot
proteins