Pacsin2
entrez
23970
canonical
uniprot
Q9WVE8
canonical
ensembl
ENSMUSG00000016664
resolver
ensp
ENSMUSP00000130098
resolver
ensp
ENSMUSP00000131504
resolver
ensp
ENSMUSP00000155334
resolver
ensp
ENSMUSP00000155481
resolver
ensp
ENSMUSP00000261267
resolver
ensp
ENSMUSP00000261271
resolver
enst
ENSMUST00000165095
resolver
enst
ENSMUST00000171436
resolver
enst
ENSMUST00000230679
resolver
enst
ENSMUST00000231184
resolver
genesymbol
Pacsin2
resolver
uniprot
Q3TDA7
resolver
uniprot
Q8BNK9
resolver
uniprot_entry
PACN2_MOUSE
resolver
uniprot_entry
Q3TDA7_MOUSE
resolver
uniprot_entry
Q8BNK9_MOUSE
resolver
amino_acid_sequence
MSVTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCGDLMNCLHERARIEKAYAQQLTEWARRWRQLVEKGPQYGTVEKAWIAVMSEAERVSELHLEVKASLMNEDFEKIKNWQKEAFHKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHHTACKEEKLAISREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKDKYEKSLKELDQTTPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNVASYKTIYRELEQSIKAADAVEDLRWFRANHGPGMAMNWPQFEEWSADLNRTLSRREKKKAVDGVTLTGINQTGDQSGQNKPGSNLSVPSNPAQSTQLQSSYNPFEDEDDTGSSISEKEDIKAKNVSSYEKTQTYPTDWSDDESNNPFSSTDANGDSNPFDEDTTSGTEVRVRALYDYEGQEHDELSFKAGDELTKIEDEDEQGWCKGRLDSGQVGLYPANYVEAIQ
uniprot
proteins
function
FUNCTION: Regulates the morphogenesis and endocytosis of caveolae (PubMed:21807942). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (PubMed:33972531). {ECO:0000269|PubMed:11082044, ECO:0000269|PubMed:15930129, ECO:0000269|PubMed:20188097, ECO:0000269|PubMed:21610094, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:21807942, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:33972531}.
uniprot
proteins
mass_dalton
55833
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="D->K: Slight increase in affinity for membranes. Increases membrane tubulation activity."; /evidence="ECO:0000269|PubMed:20188097"; MUTAGEN 50; /note="R->D: Slight decrease in affinity for membranes. Nearly abolishes membrane tubulation activity."; /evidence="ECO:0000269|PubMed:20188097"; MUTAGEN 124..125; /note="MM->TT: Nearly abolishes membrane tubulation activity."; /evidence="ECO:0000269|PubMed:20188097"; MUTAGEN 189; /note="K->E: Decreases affinity for membranes."; /evidence="ECO:0000269|PubMed:20188097"; MUTAGEN 313; /note="S->E: Reduced membrane-binding affinity."; /evidence="ECO:0000269|PubMed:26092940"; MUTAGEN 373; /note="S->D: Reduced membrane-binding affinity."; /evidence="ECO:0000269|PubMed:26092940"; MUTAGEN 478; /note="P->L: Loss of DNM1-, SYNJ1- and WASL-binding."; /evidence="ECO:0000269|PubMed:11082044
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by casein kinase 2 (CK2). Phosphorylation by PKC probably decreases the membrane binding and tubulation capacities of PACSIN2, thereby modulating the lifetime of caveolae (PubMed:26092940). {ECO:0000269|PubMed:26092940}.
uniprot
proteins
protein_family
PACSIN family
uniprot
proteins
pubmed
10431838
uniprot
proteins
pubmed
11082044
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15930129
uniprot
proteins
pubmed
16627472
uniprot
proteins
pubmed
20188097
uniprot
proteins
pubmed
20471395
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21610094
uniprot
proteins
pubmed
21693584
uniprot
proteins
pubmed
21807942
uniprot
proteins
pubmed
23129763
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
26092940
uniprot
proteins
pubmed
33972531
uniprot
proteins
sequence_length
486
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane {ECO:0000250}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection {ECO:0000250|UniProtKB:Q9UNF0}. Membrane, caveola {ECO:0000269|PubMed:21610094, ECO:0000269|PubMed:21807942, ECO:0000269|PubMed:26092940}. Cell junction, adherens junction {ECO:0000269|PubMed:33972531}. Note=Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
uniprot
proteins