Gnb5
entrez
83579
canonical
uniprot
P62882
canonical
ensembl
ENSRNOG00000047799
resolver
ensp
ENSRNOP00000066690
resolver
genesymbol
Gnb5
resolver
uniprot
O35354
resolver
uniprot
P54314
resolver
uniprot
Q5FWS8
resolver
uniprot
Q91WB3
resolver
uniprot_entry
GNB5_RAT
resolver
uniprot_sec
O35354
resolver
uniprot_sec
P54314
resolver
uniprot_sec
Q5FWS8
resolver
uniprot_sec
Q91WB3
resolver
amino_acid_sequence
MATDGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA
uniprot
proteins
function
FUNCTION: Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein-coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (By similarity). Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition (By similarity). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity). {ECO:0000250|UniProtKB:A1L271, ECO:0000250|UniProtKB:O14775, ECO:0000250|UniProtKB:P62881}.
uniprot
proteins
mass_dalton
38732
uniprot
proteins
protein_family
WD repeat G protein beta family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9622245
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P62881}.
uniprot
proteins