Fundc1
entrez
363442
canonical
uniprot
Q5BJS4
canonical
ensembl
ENSRNOG00000003470
resolver
ensembl
ENSRNOG00055016427
resolver
ensembl
ENSRNOG00060020771
resolver
ensembl
ENSRNOG00065021069
resolver
ensp
ENSRNOP00000004676
resolver
ensp
ENSRNOP00055022376
resolver
ensp
ENSRNOP00060029625
resolver
ensp
ENSRNOP00065028883
resolver
enst
ENSRNOT00000004676
resolver
enst
ENSRNOT00055027852
resolver
enst
ENSRNOT00060036003
resolver
enst
ENSRNOT00065035823
resolver
genesymbol
Fundc1
resolver
uniprot_entry
FUND1_RAT
resolver
amino_acid_sequence
MASRNPPPQDYESDDESYEVLDLTEYARRHHWWNRVFGHSSGPMVEKYSVATQIVMGGVTGWCAGFLFQKVGKLAATAVGGGFLLLQVASHSGYVQIDWKRVEKDVNKAKRQIKKRANKAAPEINNIIEEATDFIKQNIVISSGFVGGFLLGLAS
uniprot
proteins
function
FUNCTION: Integral mitochondrial outer-membrane protein that mediates the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs). In turn, mediates angiogenesis and neoangiogenesis through interference with intracellular Ca(2+) communication and regulation of the vascular endothelial growth factor receptor KDR/VEGFR2 expression at both mRNA and protein levels. Also acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality and homeostasis, by interacting with and recruiting LC3 protein family to mitochondria. Mechanistically, recruits DRP1 at ER-mitochondria contact sites leading to DRP1 oligomerization and GTPase activity to facilitate mitochondrial fission during hypoxia. Additionally, plays a role in hepatic ferroptosis by interacting directly with glutathione peroxidase/GPX4 to facilitate its recruitment into mitochondria through TOM/TIM complex where it is degraded by mitophagy. {ECO:0000250|UniProtKB:Q8IVP5}.
uniprot
proteins
mass_dalton
17159
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-13 by CK2 and at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy. Dephosphorylation is mediated by PGAM5. Phosphorylated by ULK1 at Ser-17 which enhances FUNDC1 binding to LC3. {ECO:0000250|UniProtKB:Q8IVP5}.; PTM: Ubiquitinated on Lys-119. Deubiquitinated by USP19; leading to hypoxia-induced DRP1 oligomerization and GTPase activity. {ECO:0000250|UniProtKB:Q8IVP5}.
uniprot
proteins
protein_family
FUN14 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
155
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8IVP5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IVP5}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..68; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 75..95; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 134..154; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins