Foxa2
entrez
25099
canonical
uniprot
P32182
canonical
ensembl
ENSRNOG00000013133
resolver
ensp
ENSRNOP00000017742
resolver
enst
ENSRNOT00000017742
resolver
genesymbol
Foxa2
resolver
genesymbol_syn
Hnf3b
resolver
genesymbol_syn
Tcf-3b
resolver
genesymbol_syn
Tcf3b
resolver
uniprot
G3V7Q2
resolver
uniprot_entry
FOXA2_RAT
resolver
uniprot_entry
G3V7Q2_RAT
resolver
amino_acid_sequence
MLGAVKMEGHEPSDWSSYYAEPEGYSSVSNMNASLGMNGMNTYMSMSAAAMGSGSGNMSAGSMNMSSYVGAGMSPSLAGMSPGAGAMAGMSGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDFLKVPRAPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCENELALKEAAGAGSGGGKKTAPGTQASQVQLGEAAGSASETPAGTESPHSSASPCQEHKRGGLSELKGTPASALSPPEPAPSPGQQQQAAAHLLGPPHHPGLPPEAHLKPEHHYAFNHPFSINNLMSSEQQHHHSHHHHQPHKMDLKTYEQVMHYPGGYGSPMPGSLAMGPVTNKAGLDASPLAADTSYYQGVYSRPIMNSS
uniprot
proteins
function
FUNCTION: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis (By similarity). Involved in regulation of fat metabolism. Acts synergistically with ONECUT1 to activate transcription of female-specific CYP2C12; the function is inhibited by growth hormone-activated STAT5B. Acts synergistically with HNF4A to activate transcription of APOA1. {ECO:0000250, ECO:0000269|PubMed:10931833, ECO:0000269|PubMed:19478084}.
uniprot
proteins
mass_dalton
48484
uniprot
proteins
mutagenesis
MUTAGEN 18; /note="Y->P: Reduces transcriptional activation."; /evidence="ECO:0000269|PubMed:7739897"; MUTAGEN 110; /note="L->A: Inhibits nuclear export; when associated with A-113."; /evidence="ECO:0000269|PubMed:19589781"; MUTAGEN 113; /note="L->A: Inhibits nuclear export; when associated with A-110."; /evidence="ECO:0000269|PubMed:19589781"; MUTAGEN 153; /note="R->K: Abolishes interaction with AKT1."; /evidence="ECO:0000269|PubMed:14500912"; MUTAGEN 156; /note="T->A: Constitutive active. Abolishes phosphorylation by PKB/AKT1; inhibits nuclear export; no effect on DNA binding."; /evidence="ECO:0000269|PubMed:14500912, ECO:0000269|PubMed:19589781"; MUTAGEN 280; /note="T->A: Impairs transcriptional activation; when associated with A-283."; /evidence="ECO:0000269|PubMed:19478084"; MUTAGEN 283; /note="S->A: Abolishes in vitro phosphorylation by PRKDC. Impairs transcriptional activation; when associated with A-280."; /evidence="ECO:0000269|PubMed:19478084
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation. {ECO:0000269|PubMed:14500912, ECO:0000269|PubMed:19478084, ECO:0000269|PubMed:7739897}.
uniprot
proteins
pubmed
10748198
uniprot
proteins
pubmed
10931833
uniprot
proteins
pubmed
1324404
uniprot
proteins
pubmed
14500912
uniprot
proteins
pubmed
1672118
uniprot
proteins
pubmed
19478084
uniprot
proteins
pubmed
19589781
uniprot
proteins
pubmed
7739897
uniprot
proteins
pubmed
8139574
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
uniprot
proteins