Lzts2
entrez
365468
canonical
uniprot
Q3LUD4
canonical
ensembl
ENSRNOG00000014969
resolver
ensp
ENSRNOP00000042095
resolver
enst
ENSRNOT00000048843
resolver
genesymbol
Lzts2
resolver
genesymbol_syn
LAPSER1
resolver
genesymbol_syn
LZTS2
resolver
genesymbol_syn
Lapser1
resolver
uniprot
F7FLS6
resolver
uniprot
Q24K74
resolver
uniprot
Q5XIU0
resolver
uniprot_entry
F7FLS6_RAT
resolver
uniprot_entry
LZTS2_RAT
resolver
uniprot_entry
Q5XIU0_RAT
resolver
uniprot_sec
Q24K74
resolver
amino_acid_sequence
MAIVQTLPVPLEPARETATAPQTPAMGSVSSLISGRPCPGGPAPQRHHGVPGPTFFRQQDGLLRGGYEAQEPLCPAVPPRKTVPGNSFTYVNEDFRTESPPSPSSDVEDPREHQAHNAHLRGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPSLPGFLGPRAAGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLALSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTANSPGGHLPSHGPGRGPLPGPARGVPTGPSHSDSGRSSSSKSTGSLGARVAGGLLGSGARASPGSSSGGDRSPPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSVDESEAAVCQAFGARQRRWPGEREDCASHAQQATQRVQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATFEREQQELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARAALRVSEGHARGLQEAARARELELEACSQELQRYRQEAEQLREKARHLDAEAAGLREPPVPPATTDPFLLAESDEAKVQRAAAGTGGSLRAQVERLRQELQREQRRGDEQRNSFEGERLAWQAEKEQVIRYQKQLQHNYVQMYRRNRQLEQELQQLSLELEARELADLGLSEPAPCICLEEITATEI
uniprot
proteins
function
FUNCTION: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:18490357}.
uniprot
proteins
mass_dalton
72493
uniprot
proteins
protein_family
LZTS2 family
uniprot
proteins
pubmed
17351128
uniprot
proteins
pubmed
18490357
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
670
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Preferentially localized to the mother centriole. Also localized to the midbody in cells undergoing cytokinesis. Within neurons, enriched in cell bodies and localized to branch points and the tips of axonal branches.
uniprot
proteins