SFRP4
entrez
6424
canonical
uniprot
Q6FHJ7
canonical
ensembl
ENSG00000106483
resolver
ensp
ENSP00000410715
resolver
enst
ENST00000436072
resolver
genesymbol
SFRP4
resolver
genesymbol_syn
FRPHE
resolver
hgnc
HGNC:10778
resolver
uniprot
B4DYC1
resolver
uniprot
O14877
resolver
uniprot
Q05BG7
resolver
uniprot
Q1ZYW2
resolver
uniprot
Q4G124
resolver
uniprot
Q6FHM0
resolver
uniprot
Q6PD64
resolver
uniprot_entry
SFRP4_HUMAN
resolver
uniprot_sec
B4DYC1
resolver
uniprot_sec
O14877
resolver
uniprot_sec
Q05BG7
resolver
uniprot_sec
Q1ZYW2
resolver
uniprot_sec
Q4G124
resolver
uniprot_sec
Q6FHM0
resolver
uniprot_sec
Q6PD64
resolver
amino_acid_sequence
MFLSILVALCLWLHLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLPEDVKWIDITPDMMVQERPLDVDCKRLSPDRCKCKKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVVDVKEIFKSSSPIPRTQVPLITNSSCQCPHILPHQDVLIMCYEWRSRMMLLENCLVEKWRDQLSKRSIQWEERLQEQRRTVQDKKKTAGRTSRSNPPKPKGKPPAPKPASPKKNIKTRSAQKRTNPKRV
uniprot
proteins
disease_involvement
DISEASE: Pyle disease (PYL) [MIM:265900]: A disorder characterized by cortical-bone thinning, limb deformity, bone fragility and fractures. {ECO:0000269|PubMed:27355534}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927). {ECO:0000250|UniProtKB:Q9JLS4, ECO:0000250|UniProtKB:Q9Z1N6, ECO:0000269|PubMed:12952927}.
uniprot
proteins
mass_dalton
39827
uniprot
proteins
protein_family
Secreted frizzled-related protein (sFRP) family
uniprot
proteins
pubmed
10211996
uniprot
proteins
pubmed
10728394
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12952927
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19480240
uniprot
proteins
pubmed
27355534
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19480240}. Note=Cytoplasmic in ovarian tumor cells.
uniprot
proteins