Taf6l
entrez
225895
canonical
uniprot
Q8R2K4
canonical
ensembl
ENSMUSG00000003680
resolver
ensp
ENSMUSP00000135090
resolver
ensp
ENSMUSP00000135193
resolver
ensp
ENSMUSP00000135220
resolver
enst
ENSMUST00000176496
resolver
enst
ENSMUST00000176610
resolver
enst
ENSMUST00000177216
resolver
genesymbol
Taf6l
resolver
genesymbol_syn
Paf65a
resolver
uniprot
H3BJR2
resolver
uniprot
H3BK01
resolver
uniprot
Q8C5T2
resolver
uniprot_entry
H3BJR2_MOUSE
resolver
uniprot_entry
H3BK01_MOUSE
resolver
uniprot_entry
TAF6L_MOUSE
resolver
uniprot_sec
Q8C5T2
resolver
amino_acid_sequence
MSEREERRFVEIPRESVRLMAESTGLELSDEVAALLAEDVCYRLREATQNSSQFMKHTKRRKLTVEDFNRALRWSSVEAVCGYGSQEALPLRPAREGDLYFPEDREVSLVELALATNIPKGCAETAVRVHVSYLDGKGNLAPQGSVPSAVSSLTDDLLKYYQQVTRAVLGDDPQLMKVALQDLQTNSKIAALLPYFVYVVSGVKSVSHDLEQLHRLLQVARSLIRNPHLCLGPYVRSLVGSVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQQILLSLQKVLTDPVRPLCSHYGAVVGLHALGWKAVERVLYPHLPTYWTNLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKAQAAEPNRGGLGGRGYRPAEDLPWDSLLLQESPPGGSSETGFGSGLPPPSGVAGPEDPSSLTLADIYRELYSFFGDSLATRFGTGQPAPTAPRPPGDKKEPAAAPDSVRKMPQLTASAVVSPQGDESPCGGTLATATAASESRPLPRVHRARGAPRQQGPGAGTRDVFQKSRFAPRGAPHFRFIIAGRQAGRRCRGRLFQTAFPAPYGPSPASRYVQKLPMIGRTGRPARRWALSDYSLYLPL
uniprot
proteins
function
FUNCTION: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (By similarity). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (PubMed:31005419). Functions with MYC to activate target gene expression through RNA polymerase II pause release (PubMed:31005419). {ECO:0000250|UniProtKB:Q9Y6J9, ECO:0000269|PubMed:31005419}.
uniprot
proteins
mass_dalton
67236
uniprot
proteins
protein_family
TAF6 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
31005419
uniprot
proteins
sequence_length
616
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31005419}.
uniprot
proteins