Ndst2
entrez
17423
canonical
uniprot
P52850
canonical
ensembl
ENSMUSG00000039308
resolver
ensp
ENSMUSP00000040227
resolver
ensp
ENSMUSP00000153036
resolver
ensp
ENSMUSP00000153141
resolver
enst
ENSMUST00000047490
resolver
enst
ENSMUST00000223679
resolver
enst
ENSMUST00000225000
resolver
genesymbol
Ndst2
resolver
genesymbol_syn
Hsst2
resolver
uniprot
Q3UDF4
resolver
uniprot
Q549P5
resolver
uniprot_entry
NDST2_MOUSE
resolver
uniprot_sec
Q3UDF4
resolver
uniprot_sec
Q549P5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by long N-sulfated sequences (6 or more sugar residues) in heparan sulfate, and heparin. {ECO:0000269|PubMed:12634318}.
uniprot
proteins
amino_acid_sequence
MLQLWKVVRPARQLELHRLILLLIGFSLVSMGFLAYYVSTSPKAKEPLPLPLGDCSSSGAAGPGPARPPVPPRPQRPPETTRTEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELAPGRGDMPTLTDHTHGRYVLVIYENLLKYVNLDAWSRELLDRYCVEYGVGIIGFFRAREHSLLSAQLKGFPLFLHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPGDDWTIFQSNHSTYEPVLIASHRPAELSMPGPVLRRARLPTVVQDLGLHDGIQRVLFGHGLSFWLHKLVFVDAVAYLTGKRLCLDLDRYILVDIDDIFVGKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSGKFYHTGTEEEDAGDDMLLKHRREFWWFPHMWSHMQPHLFHNRSVLADQMRLNKQFALEHGIPTDLGYAVAPHHSGVYPIHSQLYEAWKSVWGIQVTSTEEYPHLRPARYRRGFIHNGIMVLPRQTCGLFTHTIFYNEYPGGSRELDRSIRGGELFLTVLLNPISVFMTHLSNYGNDRLGLYTFESLVRFLQCWTRLRLQTLPPVPLAQKYFELFPQERSPLWQNPCDDKRHKDIWSKEKTCDRLPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSPSTFEEIQFFNGPNYHKGIDWYMDFFPVPSNASTDFLFEKSATYFDSEVVPRRGAALLPRAKIITVLINPADRAYSWYQHQRAHGDPIALNYTFYQVISASSQAPLLLRSLQNRCLVPGYYSTHLQRWLTYYPSGQLLIMDGQELRVNPAASMEIIQKFLGITPFLNYTRTLRFDEDKGFWCQGLEGGKTRCLGRSKGRRYPDMDMESRLFLTDFFRNHNLELSKLLSRLGQPAPLWLREELQHSSVG
uniprot
proteins
ec_number
2.8.2.8
uniprot
proteins
ec_number
3.5.1.-
uniprot
proteins
function
FUNCTION: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (PubMed:8294485, PubMed:10758005). Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (By similarity). Plays a role in determining the extent and pattern of sulfation of heparan sulfate (PubMed:12634318). Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Essential for the biosynthesis of sulfated heparin in mast cells, thereby enabling proper secretory granule formation and storage of mast-cell proteases (PubMed:10466726, PubMed:10466727). {ECO:0000250|UniProtKB:P52848, ECO:0000250|UniProtKB:P52849, ECO:0000269|PubMed:10466726, ECO:0000269|PubMed:10466727, ECO:0000269|PubMed:10758005, ECO:0000269|PubMed:8294485, ECO:0000305|PubMed:12634318}.
uniprot
proteins
mass_dalton
101202
uniprot
proteins
pathway_participation
PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.; PATHWAY: Glycan metabolism; heparin biosynthesis.
uniprot
proteins
protein_family
NDST subfamily
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
10466726
uniprot
proteins
pubmed
10466727
uniprot
proteins
pubmed
10758005
uniprot
proteins
pubmed
11087757
uniprot
proteins
pubmed
12634318
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
8144627
uniprot
proteins
pubmed
8294485
uniprot
proteins
sequence_length
883
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q02353}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins