Ovol2
entrez
107586
canonical
uniprot
Q8CIV7
canonical
ensembl
ENSMUSG00000037279
resolver
ensp
ENSMUSP00000044026
resolver
ensp
ENSMUSP00000099460
resolver
genesymbol
Ovol2
resolver
genesymbol_syn
Ovo2
resolver
genesymbol_syn
Zfp339
resolver
genesymbol_syn
Znf339
resolver
uniprot
Q3TIV4
resolver
uniprot
Q505Q7
resolver
uniprot
Q6F661
resolver
uniprot
Q8CIV6
resolver
uniprot
Q8K0D6
resolver
uniprot
Q9D949
resolver
uniprot_entry
OVOL2_MOUSE
resolver
uniprot_entry
Q3TIV4_MOUSE
resolver
uniprot_sec
Q505Q7
resolver
uniprot_sec
Q6F661
resolver
uniprot_sec
Q8CIV6
resolver
uniprot_sec
Q8K0D6
resolver
uniprot_sec
Q9D949
resolver
amino_acid_sequence
MPKVFLVKRRSPGVSVRSWDELPDDKRADTYIPVSLGCLLRDPPEDCRSDGGSSSGCSSSAGEPGGAESSSSPRAPEPETPELHDAQGTDGHLAAMQRPVARSKIKFTTGTCDNSVIHNCDLCGKSFRLQRMLNRHLKCHNQVKRHLCTFCGKGFNDTFDLKRHVRTHTGIRPYKCEVCNKAFTQRCSLESHLKKIHGVQQQYAYKQRRDKLYVCEDCGYTGPTQEDLYLHVNSDHPGSTFLKKTSKKLAALMQNKLTSPLQENSTLSEEEEKK
uniprot
proteins
function
FUNCTION: Zinc-finger transcription repressor factor (PubMed:15225875, PubMed:23319585, PubMed:36228616). Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (PubMed:24735878, PubMed:24735879). Positively regulates neuronal differentiation (PubMed:16423343, PubMed:23319585). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (By similarity). Important for the correct development of primordial germ cells in embryos (PubMed:28059165). Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes. In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity (PubMed:36228616). {ECO:0000250|UniProtKB:Q9BRP0, ECO:0000269|PubMed:15225875, ECO:0000269|PubMed:16423343, ECO:0000269|PubMed:23319585, ECO:0000269|PubMed:24735878, ECO:0000269|PubMed:24735879, ECO:0000269|PubMed:28059165, ECO:0000269|PubMed:36228616}.
uniprot
proteins
mass_dalton
30685
uniprot
proteins
mutagenesis
MUTAGEN 120; /note="C->Y: Causes obesity in mice. Obesity develops with normal food intake and reduced energy expenditure. Mice are cold intolerant with defective brown/beige adipose tissues. Reduces interaction with CEBPA."; /evidence="ECO:0000269|PubMed:36228616
uniprot
proteins
protein_family
Krueppel C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
12213202
uniprot
proteins
pubmed
15225875
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16423343
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23319585
uniprot
proteins
pubmed
24735878
uniprot
proteins
pubmed
24735879
uniprot
proteins
pubmed
28059165
uniprot
proteins
pubmed
36228616
uniprot
proteins
pubmed
9468311
uniprot
proteins
sequence_length
274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:36228616, ECO:0000269|PubMed:9468311}.
uniprot
proteins