Alox5ap
entrez
11690
canonical
uniprot
P30355
canonical
ensembl
ENSMUSG00000060063
resolver
ensp
ENSMUSP00000071130
resolver
ensp
ENSMUSP00000271323
resolver
enst
ENSMUST00000071130
resolver
genesymbol
Alox5ap
resolver
genesymbol_syn
Flap
resolver
uniprot
Q9D138
resolver
uniprot_entry
AL5AP_MOUSE
resolver
uniprot_sec
Q9D138
resolver
amino_acid_sequence
MDQEAVGNVVLLALVTLISVVQNAFFAHKVEHESKAHNGRSFQRTGTLAFERVYTANQNCVDAYPTFLVVLWTAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSFAGILNHYLIFFFGSDFENYIRTVSTTISPLLLIP
uniprot
proteins
function
FUNCTION: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity). {ECO:0000250, ECO:0000269|PubMed:19075240}.
uniprot
proteins
mass_dalton
18136
uniprot
proteins
protein_family
MAPEG family
uniprot
proteins
pubmed
1480129
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19075240
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
161
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:19075240}; Multi-pass membrane protein {ECO:0000269|PubMed:19075240}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..30; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 53..77; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 81..102; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 116..128; /note="Helical"; /evidence="ECO:0000250
uniprot
proteins