Lats1
entrez
16798
canonical
uniprot
Q8BYR2
canonical
ensembl
ENSMUSG00000040021
resolver
ensp
ENSMUSP00000132078
resolver
ensp
ENSMUSP00000151533
resolver
enst
ENSMUST00000165952
resolver
enst
ENSMUST00000217931
resolver
genesymbol
Lats1
resolver
genesymbol_syn
Warts
resolver
uniprot
B2RY46
resolver
uniprot
Q9Z0W4
resolver
uniprot_entry
LATS1_MOUSE
resolver
uniprot_sec
B2RY46
resolver
uniprot_sec
Q9Z0W4
resolver
amino_acid_sequence
MKRGEKPEGYRQMRPKTFPASNYPGSSRQMLQEIRESLRNLSKPSDASKAEHNLNKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETSSSRSPSEVNPQMFQDLQAAGFDEDMVIQALQKTNNRSIEAAVEFISKMSYQDPRREQMSAAAARPINATMKPGNVQHSINRKQSWKGSKESLVPQRHGPSLGENVVYRSESPNSQADVGRPLSGSGIAAFAQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPSSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLTTSPMNPPSQAQRAISSVPVGRQPIIMQSTSKFNFTPGRPGVQNGGGQSDFIVHQNVPTGSVTRQPPPPYPLTPANGQSPSALQTGASAAPPSFANGNVPQSMMVPNRNSHNMELYNINVPGLQTAWPQSSSAPAQSSPSGGHEIPTWQPNIPVRSNSFNNPLGSRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWMPQPVQTVQPTPFSEGTASSVPVIPPVAEAPSYQGPPPPYPKHLLHQNPSVPPYESVSKPCKDEQPSLPKEDDSEKSADSGDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSNCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDGSEEENISDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYIHSQGSEQQSDEDDQHTSSDGNNRDLVYV
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:21145499). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:21145499). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:21145499). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:9988269). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (By similarity). Involved in the control of p53 expression (By similarity). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (By similarity). May also play a role in endocrine function (By similarity). Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (By similarity). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000250|UniProtKB:O95835, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988269}.
uniprot
proteins
mass_dalton
126258
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated and phosphorylated during M-phase of the cell cycle. Phosphorylated by STK3/MST2 at Ser-908 and Thr-1078, which results in its activation. Phosphorylated by MAP4Ks; in parallel to STK3/MST2 and resulting to its activation. Phosphorylation at Ser-463 by NUAK1 and NUAK2 leads to decreased protein level and is required to regulate cellular senescence and cellular ploidy. {ECO:0000250|UniProtKB:O95835}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21145499
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
39173637
uniprot
proteins
pubmed
9988268
uniprot
proteins
pubmed
9988269
uniprot
proteins
sequence_length
1129
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O95835}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:O95835}. Midbody {ECO:0000250|UniProtKB:O95835}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000250|UniProtKB:O95835}. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis. {ECO:0000250|UniProtKB:O95835}.
uniprot
proteins