P28078
uniprot
P28078
canonical
amino_acid_sequence
MEHEQKSGAVLLRLLRLLWLLPHSWAVLEASTPVLWDDPQNHTFRHTLFCQDGIPNIGLSETYDEDELFSFDFSQNTRVPRLPDFAEWAQGQGDASAIAFGKSFCEMLMREVSPKLEGQIPVSRGLSVAEVFTLKPLEFGKPNTLVCFISNLFPPTLTVNWQLHSAPVEGASPTSISAVDGLTFQAFSYLNFTPEPFDLYSCTVTHEIDRYTAIAYWVPQNALPSDLLENALCGVAFALGVLGTIIGIVFFLCSQRPCSGD
uniprot
proteins
function
FUNCTION: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. {ECO:0000250|UniProtKB:P28067}.
uniprot
proteins
mass_dalton
28950
uniprot
proteins
protein_family
MHC class II family
uniprot
proteins
pubmed
1922366
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9768758
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
uniprot
proteins
transmembrane_region
TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins