Plat
entrez
25692
canonical
uniprot
P19637
canonical
ensembl
ENSRNOG00000019018
resolver
ensembl
ENSRNOG00060027808
resolver
ensp
ENSRNOP00000025764
resolver
ensp
ENSRNOP00000071993
resolver
ensp
ENSRNOP00060040283
resolver
enst
ENSRNOT00000025763
resolver
enst
ENSRNOT00060048368
resolver
genesymbol
Plat
resolver
uniprot
A0A8L2QF83
resolver
uniprot_entry
A0A8L2QF83_RAT
resolver
uniprot_entry
TPA_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by SERPINA5 (By similarity). Inhibited by SERPINE1 (By similarity). {ECO:0000250|UniProtKB:P00750}.
uniprot
proteins
amino_acid_sequence
MKGELLCVLLLCGVAFTLPDQGIHRRFRRGARSYRATCRDEQTQTTYQQHQSWLRPMLRGNRVEYCRCNSGLAQCHSVPVRSCSEPRCFNGGTCQQALYFSDFVCQCPDGFVGKRCDIDTRATCFEGQGITYRGTWSTAENGAECINWNSSALSQKPYSARRPNAIKLGLGNHNYCRNPDRDVKPWCYVFKAGKYTTEFCSTPACPKGPTEDCYVGKGVTYRGTHSFTTSKASCLPWNSMILIGKTYTAWRANSQALGLGRHNYCRNPDGDAKPWCHVMKDRKLTWEYCDMSPCSTCGLRQYKQPQFRIKGGLFTDITSHPWQAAIFVKNKRSPGERFLCGGVLISSCWVLSAAHCFVERFPPHHLKVVLGRTYRVVPGEEEQTFEIEKYIVHKEFDDDTYDNDIALLQLRSDSSQCAQESSSVGTACLPDPDVQLPDWTECELSGYGKHEASSPFFSDRLKEAHVRLYPSSRCTSQHLFNKTITSNMLCAGDTRTGGNQDVHDACQGDSGGPLVCMIDKRMTLLGIISWGLGCGQKDVPGIYTKVTNYLNWIQDNMKQ
uniprot
proteins
ec_number
3.4.21.68
uniprot
proteins
function
FUNCTION: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (PubMed:1515147). {ECO:0000269|PubMed:1515147}.
uniprot
proteins
mass_dalton
62903
uniprot
proteins
post_translational_modification
PTM: The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-308 catalyzed by plasmin, tissue kallikrein or factor Xa.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
1515147
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2105315
uniprot
proteins
pubmed
3148445
uniprot
proteins
sequence_length
559
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space.
uniprot
proteins