Hipk3
entrez
15259
canonical
uniprot
Q9ERH7
canonical
ensembl
ENSMUSG00000027177
resolver
ensp
ENSMUSP00000028600
resolver
ensp
ENSMUSP00000106753
resolver
ensp
ENSMUSP00000280331
resolver
enst
ENSMUST00000028600
resolver
enst
ENSMUST00000111124
resolver
genesymbol
Hipk3
resolver
genesymbol_syn
Fist3
resolver
uniprot
A2AQH2
resolver
uniprot
A2RRJ7
resolver
uniprot
O88906
resolver
uniprot
Q3UST3
resolver
uniprot
Q9QZR2
resolver
uniprot_entry
A2RRJ7_MOUSE
resolver
uniprot_entry
HIPK3_MOUSE
resolver
uniprot_entry
Q3UST3_MOUSE
resolver
uniprot_sec
A2AQH2
resolver
uniprot_sec
O88906
resolver
uniprot_sec
Q9QZR2
resolver
amino_acid_sequence
MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSGCVFQERTYPQIHVNGRNFGNSHPSTKGSAFQTKIPFTKPRGHSFSLQAGAIVVKDTAGATKVLAAQAQQAGVEAPRAVVWRNRLHFLEGPQRCGLKRKSEELENHSGAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTSGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDIVHVNTVMDLEGGDLLAEKADRREFVNLLKKMLLIDADLRITPIETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSPSSCETNNHSKMSLLRPVASNGTAALAANFTKVGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFHQTLIICPPAIQGIPAAHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQQTWSGRTQQMLIPAWQQVTPMAPAAATLTSEGMAGSQRLGDWGKMIPHSNHYNSVMPPPLLTNQITLSAPQPISVGIAHVVWPQPATTKKNKLCQNRSNSLQNTNIPHSAFISPKIISGKEVEEVSCVDTQDNHTSEGEAGTCREASVRQDSSVSDKQRQTIIIADSPSPAVSVITISSDSDDEETSPRPSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDDEQESGCETVDGSPTSDSSGHDSPFAENSFVEDAHQNTELGTCAGPEAKPAVGTAVEPPVGRESGLSVDEHMANTDSTCQPLRKGQPAPGKLHQPPALGARQQKPAAAFPQQHLNLSQVQHFGTGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGSTHLGGQPTLLPYPSSASLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGINPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). {ECO:0000269|PubMed:11034606, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:20484411}.
uniprot
proteins
mass_dalton
130081
uniprot
proteins
mutagenesis
MUTAGEN 226; /note="K->R: Loss of kinase activity and impaired activation of SF1."; /evidence="ECO:0000269|PubMed:11034606, ECO:0000269|PubMed:17210646"; MUTAGEN 226; /note="K->S: Impairs catalytic activity."; /evidence="ECO:0000269|PubMed:11034606, ECO:0000269|PubMed:17210646"; MUTAGEN 322; /note="D->N: Impairs catalytic activity and abolishes interaction with DAXX."; /evidence="ECO:0000269|PubMed:11034606
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated, but autophosphorylation is not required for catalytic activity. {ECO:0000250}.; PTM: May be sumoylated.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
HIPK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11034606
uniprot
proteins
pubmed
17210646
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20484411
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9725910
uniprot
proteins
pubmed
9748262
uniprot
proteins
sequence_length
1192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
uniprot
proteins