FIP1L1
entrez
81608
canonical
uniprot
Q6UN15
canonical
ensembl
ENSG00000145216
resolver
ensp
ENSP00000302993
resolver
ensp
ENSP00000336752
resolver
ensp
ENSP00000351383
resolver
ensp
ENSP00000421691
resolver
ensp
ENSP00000515302
resolver
ensp
ENSP00000515303
resolver
ensp
ENSP00000515304
resolver
ensp
ENSP00000515305
resolver
ensp
ENSP00000515306
resolver
ensp
ENSP00000515307
resolver
ensp
ENSP00000515308
resolver
ensp
ENSP00000515309
resolver
ensp
ENSP00000515311
resolver
ensp
ENSP00000515312
resolver
ensp
ENSP00000515317
resolver
ensp
ENSP00000515319
resolver
ensp
ENSP00000515320
resolver
ensp
ENSP00000515321
resolver
ensp
ENSP00000515322
resolver
ensp
ENSP00000515324
resolver
ensp
ENSP00000515326
resolver
ensp
ENSP00000515327
resolver
ensp
ENSP00000515328
resolver
ensp
ENSP00000515330
resolver
ensp
ENSP00000515331
resolver
ensp
ENSP00000515332
resolver
ensp
ENSP00000515333
resolver
ensp
ENSP00000515334
resolver
ensp
ENSP00000515335
resolver
ensp
ENSP00000515336
resolver
ensp
ENSP00000515340
resolver
ensp
ENSP00000515341
resolver
ensp
ENSP00000515342
resolver
ensp
ENSP00000515343
resolver
ensp
ENSP00000515346
resolver
ensp
ENSP00000541780
resolver
ensp
ENSP00000541783
resolver
ensp
ENSP00000541785
resolver
ensp
ENSP00000541786
resolver
ensp
ENSP00000541787
resolver
ensp
ENSP00000541788
resolver
ensp
ENSP00000598431
resolver
ensp
ENSP00000612802
resolver
ensp
ENSP00000612803
resolver
ensp
ENSP00000612804
resolver
ensp
ENSP00000612806
resolver
ensp
ENSP00000612811
resolver
ensp
ENSP00000712306
resolver
ensp
ENSP00000712312
resolver
ensp
ENSP00000712315
resolver
enst
ENST00000504094
resolver
enst
ENST00000703451
resolver
enst
ENST00000703452
resolver
enst
ENST00000703453
resolver
enst
ENST00000703454
resolver
enst
ENST00000703455
resolver
enst
ENST00000703456
resolver
enst
ENST00000703457
resolver
enst
ENST00000703458
resolver
enst
ENST00000703460
resolver
enst
ENST00000703461
resolver
enst
ENST00000703466
resolver
enst
ENST00000703468
resolver
enst
ENST00000703469
resolver
enst
ENST00000703470
resolver
enst
ENST00000703471
resolver
enst
ENST00000703473
resolver
enst
ENST00000703475
resolver
enst
ENST00000703476
resolver
enst
ENST00000703478
resolver
enst
ENST00000703480
resolver
enst
ENST00000703481
resolver
enst
ENST00000703482
resolver
enst
ENST00000703483
resolver
enst
ENST00000703484
resolver
enst
ENST00000703485
resolver
enst
ENST00000703486
resolver
enst
ENST00000703490
resolver
enst
ENST00000703491
resolver
enst
ENST00000703492
resolver
enst
ENST00000703497
resolver
enst
ENST00000703500
resolver
genesymbol
FIP1L1
resolver
genesymbol_syn
FIP1
resolver
genesymbol_syn
RHE
resolver
hgnc
HGNC:19124
resolver
uniprot
A0A994J3I9
resolver
uniprot
A0A994J3J1
resolver
uniprot
A0A994J3K1
resolver
uniprot
A0A994J3K5
resolver
uniprot
A0A994J3L5
resolver
uniprot
A0A994J3M0
resolver
uniprot
A0A994J3P6
resolver
uniprot
A0A994J3Q0
resolver
uniprot
A0A994J3Q5
resolver
uniprot
A0A994J3R0
resolver
uniprot
A0A994J3R5
resolver
uniprot
A0A994J3S0
resolver
uniprot
A0A994J3S6
resolver
uniprot
A0A994J3T5
resolver
uniprot
A0A994J438
resolver
uniprot
A0A994J442
resolver
uniprot
A0A994J453
resolver
uniprot
A0A994J458
resolver
uniprot
A0A994J464
resolver
uniprot
A0A994J469
resolver
uniprot
A0A994J474
resolver
uniprot
A0A994J6B4
resolver
uniprot
A0A994J6C6
resolver
uniprot
A0A994J6D3
resolver
uniprot
A0A994J6D6
resolver
uniprot
A0A994J6E0
resolver
uniprot
A0A994J6E2
resolver
uniprot
A0A994J6N5
resolver
uniprot
A0A994J6P0
resolver
uniprot
A0A994J6Q5
resolver
uniprot
A0A994J6R0
resolver
uniprot
B4DIR3
resolver
uniprot
G3XAD6
resolver
uniprot
H0Y8P7
resolver
uniprot
Q0VGE0
resolver
uniprot
Q499Y4
resolver
uniprot
Q49AU3
resolver
uniprot
Q7Z608
resolver
uniprot
Q8WVN3
resolver
uniprot
Q96F80
resolver
uniprot
Q9H077
resolver
uniprot_entry
A0A994J3I9_HUMAN
resolver
uniprot_entry
A0A994J3J1_HUMAN
resolver
uniprot_entry
A0A994J3K1_HUMAN
resolver
uniprot_entry
A0A994J3K5_HUMAN
resolver
uniprot_entry
A0A994J3L5_HUMAN
resolver
uniprot_entry
A0A994J3M0_HUMAN
resolver
uniprot_entry
A0A994J3P6_HUMAN
resolver
uniprot_entry
A0A994J3Q0_HUMAN
resolver
uniprot_entry
A0A994J3Q5_HUMAN
resolver
uniprot_entry
A0A994J3R0_HUMAN
resolver
uniprot_entry
A0A994J3R5_HUMAN
resolver
uniprot_entry
A0A994J3S0_HUMAN
resolver
uniprot_entry
A0A994J3S6_HUMAN
resolver
uniprot_entry
A0A994J3T5_HUMAN
resolver
uniprot_entry
A0A994J438_HUMAN
resolver
uniprot_entry
A0A994J442_HUMAN
resolver
uniprot_entry
A0A994J453_HUMAN
resolver
uniprot_entry
A0A994J458_HUMAN
resolver
uniprot_entry
A0A994J464_HUMAN
resolver
uniprot_entry
A0A994J469_HUMAN
resolver
uniprot_entry
A0A994J474_HUMAN
resolver
uniprot_entry
A0A994J6B4_HUMAN
resolver
uniprot_entry
A0A994J6C6_HUMAN
resolver
uniprot_entry
A0A994J6D3_HUMAN
resolver
uniprot_entry
A0A994J6D6_HUMAN
resolver
uniprot_entry
A0A994J6E0_HUMAN
resolver
uniprot_entry
A0A994J6E2_HUMAN
resolver
uniprot_entry
A0A994J6N5_HUMAN
resolver
uniprot_entry
A0A994J6P0_HUMAN
resolver
uniprot_entry
A0A994J6Q5_HUMAN
resolver
uniprot_entry
A0A994J6R0_HUMAN
resolver
uniprot_entry
FIP1_HUMAN
resolver
uniprot_entry
H0Y8P7_HUMAN
resolver
uniprot_sec
B4DIR3
resolver
uniprot_sec
G3XAD6
resolver
uniprot_sec
Q0VGE0
resolver
uniprot_sec
Q499Y4
resolver
uniprot_sec
Q49AU3
resolver
uniprot_sec
Q7Z608
resolver
uniprot_sec
Q8WVN3
resolver
uniprot_sec
Q96F80
resolver
uniprot_sec
Q9H077
resolver
amino_acid_sequence
MSAGEVERLVSELSGGTGGDEEEEWLYGGPWDVHVHSDLAKDLDENEVERPEEENASANPPSGIEDETAENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTTGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITAEDCTMEVTPGAEIQDGRFNLFKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving FIP1L1 is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA). {ECO:0000269|PubMed:12660384, ECO:0000269|PubMed:12808148}.
uniprot
proteins
function
FUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}.
uniprot
proteins
mass_dalton
66526
uniprot
proteins
protein_family
FIP1 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12660384
uniprot
proteins
pubmed
12808148
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14749727
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15767428
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15937220
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19224921
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29276085
uniprot
proteins
sequence_length
594
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins