Gsdmc4
entrez
74548
canonical
uniprot
Q3TR54
canonical
ensembl
ENSMUSG00000055748
resolver
ensp
ENSMUSP00000066072
resolver
ensp
ENSMUSP00000140269
resolver
enst
ENSMUST00000063530
resolver
enst
ENSMUST00000188108
resolver
genesymbol
Gsdmc4
resolver
genesymbol_syn
GsdmC-2
resolver
uniprot
A0A679B0N4
resolver
uniprot
E9QKJ0
resolver
uniprot
Q9D326
resolver
uniprot_entry
A0A679B0N4_MOUSE
resolver
uniprot_entry
GSDC4_MOUSE
resolver
uniprot_sec
E9QKJ0
resolver
uniprot_sec
Q9D326
resolver
activity_regulation
ACTIVITY REGULATION: [Gasdermin-C4]: The full-length protein before cleavage is inactive: intramolecular interactions between N- and C-terminal domains mediate autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the released N-terminal moiety (Gasdermin-C4, N-terminal) following cleavage by caspase CASP8. {ECO:0000250|UniProtKB:Q9BYG8}.
uniprot
proteins
amino_acid_sequence
MGYSFDRASKDVVKKLQGRDLRPVECLSDATKFRLFHILQETPRSGWETEDIPVGFTLLDLLEPNFPVPEPEVSAPKPFIHVQSTDLEANLNVADIARGGVGYVGYGGYNIEVQSTSIPNPKLEILQNRKLLDKLPTFMKFCRMERKNLYVVTEAYEVSKDTMLTGLSSVNLLVKGFFKQLFKVRGKAGRSEKYSIPIPKGSVLAYKKQQLVIENNTCVILPSATKKKMTFPDRPLKLYDLPVTLRYQEEVIETGSWIDDIDPIGTIEEPANLNFMCLQHEVSEQTQLLAELSKDVQEVVFSSFLHMLSDRDVLYDLMKMLELNQLGHMDGPGGKILDELRKDSSTPHDVLKDLNLYLLQALLVLSDTQLCLLAQSVKMGLLPHQVELVKSILQTNFKYSSNTPFTLQPQLLAPLQGEGLAITYELLEECGLKMELNNPRSTWDLEAKMPLSALYGSLSFLQQLQKANSSSKPSLSPGYI
uniprot
proteins
function
FUNCTION: [Gasdermin-C4]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C4, N-terminal) binds to membranes and forms pores, triggering pyroptosis. {ECO:0000250|UniProtKB:Q9BYG8}.; FUNCTION: [Gasdermin-C4, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis. Produced by the cleavage of gasdermin-C4 by caspase CASP8 in response to death signals. After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. {ECO:0000250|UniProtKB:Q9BYG8}.
uniprot
proteins
mass_dalton
53992
uniprot
proteins
post_translational_modification
PTM: Cleavage by CASP8 relieves autoinhibition by releasing the N-terminal moiety (Gasdermin-C4, N-terminal) that initiates pyroptosis. {ECO:0000269|PubMed:34012073}.; PTM: Palmitoylated. {ECO:0000250|UniProtKB:Q9BYG8}.
uniprot
proteins
protein_family
Gasdermin family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17350798
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
34012073
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Gasdermin-C4]: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BYG8}.; SUBCELLULAR LOCATION: [Gasdermin-C4, N-terminal]: Cell membrane {ECO:0000250|UniProtKB:Q5Y4Y6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}.
uniprot
proteins