Nsdhl
entrez
309262
canonical
uniprot
Q5PPL3
canonical
ensembl
ENSRNOG00000057814
resolver
ensembl
ENSRNOG00055023928
resolver
ensembl
ENSRNOG00060019809
resolver
ensembl
ENSRNOG00065014412
resolver
ensp
ENSRNOP00000069662
resolver
ensp
ENSRNOP00055033405
resolver
ensp
ENSRNOP00060028069
resolver
ensp
ENSRNOP00065018524
resolver
enst
ENSRNOT00000091154
resolver
enst
ENSRNOT00055041075
resolver
enst
ENSRNOT00060034230
resolver
enst
ENSRNOT00065023803
resolver
genesymbol
Nsdhl
resolver
uniprot_entry
NSDHL_RAT
resolver
amino_acid_sequence
MEQAVRSESKKGQVTGTDLINEVSKAKKCTVIGGSGFLGQHMVEQLLSRGYAVNVFDVRQGFDNPRVQFFIGDLCNQQDLYPALKGVSTVFHCASPPSNSNNKELFYRVNSTGTKTVIETCKEAGVQKLILTSSASVVFEGVDIKNGTEDLPYAMKPIDYYTETKILQERAVLDANDPKKNFLTAAIRPHGIFGPRDPQLVPVLIDAARKGKMKFMIGNGKNLVDFTFVENVVHGHILAAEHLSRDAGLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYRVAYYLAFLLSLLVMVLSPLIQIQTTFTPFRVALAGTFHYYSCEKAKKLIGYRPLVTMDDAVERTVQSFHHLRKDK
uniprot
proteins
ec_number
1.1.1.170
uniprot
proteins
function
FUNCTION: Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis. Also plays a role in the regulation of the endocytic trafficking of EGFR. {ECO:0000250|UniProtKB:Q15738}.
uniprot
proteins
mass_dalton
40412
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 4/6.
uniprot
proteins
protein_family
3-beta-HSD family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9R1J0}; Single-pass membrane protein {ECO:0000255}. Lipid droplet {ECO:0000250|UniProtKB:Q9R1J0}. Note=Trafficking through the Golgi is necessary for ER membrane localization. {ECO:0000250|UniProtKB:Q9R1J0}.
uniprot
proteins
transmembrane_region
TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins