MEAK7
entrez
57707
canonical
uniprot
Q6P9B6
canonical
ensembl
ENSG00000140950
resolver
ensp
ENSP00000343635
resolver
ensp
ENSP00000569835
resolver
ensp
ENSP00000569836
resolver
ensp
ENSP00000569837
resolver
ensp
ENSP00000569838
resolver
ensp
ENSP00000569839
resolver
ensp
ENSP00000569840
resolver
ensp
ENSP00000569841
resolver
ensp
ENSP00000596630
resolver
ensp
ENSP00000596631
resolver
ensp
ENSP00000596633
resolver
ensp
ENSP00000641357
resolver
ensp
ENSP00000641358
resolver
ensp
ENSP00000641360
resolver
enst
ENST00000343629
resolver
enst
ENST00000899776
resolver
enst
ENST00000899777
resolver
enst
ENST00000899778
resolver
enst
ENST00000899779
resolver
enst
ENST00000899780
resolver
enst
ENST00000899781
resolver
enst
ENST00000899782
resolver
enst
ENST00000926571
resolver
enst
ENST00000926572
resolver
enst
ENST00000926574
resolver
enst
ENST00000971298
resolver
enst
ENST00000971299
resolver
enst
ENST00000971301
resolver
genesymbol
MEAK7
resolver
genesymbol_syn
KIAA1609
resolver
genesymbol_syn
TLDC1
resolver
hgnc
HGNC:29325
resolver
uniprot
A8K5C2
resolver
uniprot
Q8IZ64
resolver
uniprot
Q9HCG3
resolver
uniprot
Q9NTE8
resolver
uniprot_entry
A8K5C2_HUMAN
resolver
uniprot_entry
MEAK7_HUMAN
resolver
uniprot_sec
Q8IZ64
resolver
uniprot_sec
Q9HCG3
resolver
uniprot_sec
Q9NTE8
resolver
amino_acid_sequence
MGNSRSRVGRSFCSQFLPEEQAEIDQLFDALSSDKNSPNVSSKSFSLKALQNHVGEALPPEMVTRLYDGMRRVDLTGKAKGPSENVSQEQFTASMSHLLKGNSEEKSLMIMKMISATEGPVKAREVQKFTEDLVGSVVHVLSHRQELRGWTGKEAPGPNPRVQVLAAQLLSDMKLQDGKRLLGPQWLDYDCDRAVIEDWVFRVPHVAIFLSVVICKGFLILCSSLDLTTLVPERQVDQGRGFESILDVLSVMYINAQLPREQRHRWCLLFSSELHGHSFSQLCGHITHRGPCVAVLEDHDKHVFGGFASCSWEVKPQFQGDNRCFLFSICPSMAVYTHTGYNDHYMYLNHGQQTIPNGLGMGGQHNYFGLWVDVDFGKGHSRAKPTCTTYNSPQLSAQENFQFDKMEVWAVGDPSEEQLAKGNKSILDADPEAQALLEISGHSRHSEGLREVPDDE
uniprot
proteins
function
FUNCTION: Activates an alternative mTOR signaling pathway through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration (PubMed:29750193). Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome (PubMed:29750193). Binds to the vacuolar-type ATPase (V-ATPase) complex, triggering a conformational change and is likely to regulate its activity (PubMed:35672408, PubMed:35994636). No effect on V-ATPase activity was observed in vitro in one study although it was suggested that it may have inhibitory activity in vivo (PubMed:35672408). However, another study showed that it can promote V-ATPase activity (PubMed:38593795). Protects neuronal cells against oxidative stress (By similarity). {ECO:0000250|UniProtKB:Q8K0P3, ECO:0000269|PubMed:29750193, ECO:0000269|PubMed:35672408, ECO:0000269|PubMed:35994636, ECO:0000269|PubMed:38593795}.
uniprot
proteins
mass_dalton
50994
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Abolishes lysosomal location."; /evidence="ECO:0000269|PubMed:29750193
uniprot
proteins
pubmed
10997877
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20213681
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24223779
uniprot
proteins
pubmed
29750193
uniprot
proteins
pubmed
35672408
uniprot
proteins
pubmed
35994636
uniprot
proteins
pubmed
38593795
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:24223779}. Cytoplasm {ECO:0000269|PubMed:24223779}. Lysosome {ECO:0000269|PubMed:29750193}.
uniprot
proteins