Dcxr
entrez
171408
canonical
uniprot
Q920P0
canonical
ensembl
ENSRNOG00000081885
resolver
ensembl
ENSRNOG00055032272
resolver
ensembl
ENSRNOG00060009037
resolver
ensembl
ENSRNOG00065004713
resolver
ensp
ENSRNOP00000108490
resolver
ensp
ENSRNOP00055045920
resolver
ensp
ENSRNOP00060011783
resolver
ensp
ENSRNOP00065004687
resolver
enst
ENSRNOT00055055726
resolver
enst
ENSRNOT00060015158
resolver
enst
ENSRNOT00065006829
resolver
genesymbol
Dcxr
resolver
genesymbol_syn
Glb
resolver
uniprot_entry
DCXR_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Competitively inhibited by butanoic acid, which binds to the enzyme-NADP(+) complex (PubMed:11882650, PubMed:12604240). Inhibited by 4-methyl-[1,2,3]-thiadiazole-5-carboxylic acid benzyloxyamide (MTB) and 4-methylthiophene-2-carboxylic acid N-(2,3,3-trichloroacryloyl)-hydrazide (MTT) (PubMed:15906319). {ECO:0000269|PubMed:11882650, ECO:0000269|PubMed:12604240, ECO:0000269|PubMed:15906319}.
uniprot
proteins
amino_acid_sequence
MDLGLAGRRALVTGAGKGIGRSTVLALQAAGAQVVAVSRTREDLDSLVRECPGVEPVCVDLADWEATEQALSNVGPVDLLVNNAAVATLQPFLEVTKEACDTSFNVNFRAVVQVSQIVARGMIARGVPGAIVNVSSQASQRALTNHTVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTPMGRANWSDPHKAKVMLDRIPLGKFAEVENVVDTILFLLSNRSSMTTGSALPVDGGFLAT
uniprot
proteins
ec_number
1.1.1.10
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose (PubMed:11882650, PubMed:12604240). Can use both NAD and NADP as cosubstrate but shows higher activity with NADP (PubMed:11882650). Participates in the uronate cycle of glucose metabolism (PubMed:11882650). May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules (PubMed:11882650). {ECO:0000269|PubMed:11882650, ECO:0000269|PubMed:12604240, ECO:0000303|PubMed:11882650}.
uniprot
proteins
mass_dalton
25720
uniprot
proteins
mutagenesis
MUTAGEN 136; /note="S->A: Loss of activity."; /evidence="ECO:0000269|PubMed:12604240"; MUTAGEN 137; /note="Q->M: Slightly reduced activity. Loss of activity for sugars; when associated with F-143 and L-146."; /evidence="ECO:0000269|PubMed:12604240"; MUTAGEN 143; /note="L->F: Has a minimal effect on interaction with MTT and MTB inhibitors. Slightly reduced activity. Loss of activity for sugars; when associated with M-137 and L-146."; /evidence="ECO:0000269|PubMed:12604240, ECO:0000269|PubMed:15906319"; MUTAGEN 146; /note="H->L: Slightly reduced activity. Reduces interaction with MTT and MTB inhibitors by about 7-fold. Loss of activity for sugars; when associated with M-137; F-143 and L-146."; /evidence="ECO:0000269|PubMed:12604240, ECO:0000269|PubMed:15906319"; MUTAGEN 149; /note="Y->F: Loss of activity."; /evidence="ECO:0000269|PubMed:12604240"; MUTAGEN 153; /note="K->M: Loss of activity."; /evidence="ECO:0000269|PubMed:12604240"; MUTAGEN 190; /note="N->V: Slightly reduced activity. Loss of activity for sugars; when associated with S-191."; /evidence="ECO:0000269|PubMed:12604240"; MUTAGEN 191; /note="W->F: Slightly reduced activity. Has minimal effect on the binding of MTB, but a more pronounced reduction on the binding of MTT."; /evidence="ECO:0000269|PubMed:12604240, ECO:0000269|PubMed:15906319"; MUTAGEN 191; /note="W->S: Slightly reduced activity. Has minimal effect on the binding of MTT, but a more pronounced reduction on the binding of MTB. Loss of activity for sugars; when associated with V-190."; /evidence="ECO:0000269|PubMed:12604240, ECO:0000269|PubMed:15906319
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
11882650
uniprot
proteins
pubmed
12604240
uniprot
proteins
pubmed
15906319
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q91X52}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q91X52}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q91XV4}. Note=Probably recruited to membranes via an interaction with phosphatidylinositol. {ECO:0000250|UniProtKB:Q91XV4}.
uniprot
proteins