Trim55
entrez
381485
canonical
uniprot
G3X8Y1
canonical
ensembl
ENSMUSG00000060913
resolver
ensp
ENSMUSP00000029139
resolver
ensp
ENSMUSP00000160014
resolver
ensp
ENSMUSP00000275882
resolver
enst
ENSMUST00000029139
resolver
enst
ENSMUST00000249916
resolver
genesymbol
Trim55
resolver
uniprot
A0AAQ4VMY0
resolver
uniprot
Q8C6Y1
resolver
uniprot_entry
A0AAQ4VMY0_MOUSE
resolver
uniprot_entry
TRI55_MOUSE
resolver
uniprot_sec
Q8C6Y1
resolver
amino_acid_sequence
MSTSLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNPYLPTRGGTTVASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKLDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAVLVGSNDRVQGVISQLEDTCKTIEECCRKQKQDLCEKFDHLYGILEERKTEMTQAITRTQEEKLEHVRTLIRKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLQKIVEASKAFQMEKLEQGYEIMSNFTVNLNREEKIIREIDFSREEEEEEDAGEIDEEGEGEDAVEVEEAENVQIASSGEEESLEKAAEPSQLPAELQVAPEPLPASSPEPFSSMPPAADVLVTQGEVVPIGSQQTTQSETSGPSAAETADPLFYPSWYKGQSRKTSSNPPCTHGSEGLGQIGPLGIEDSSVQSAEVAEAATNEQAAVSGKESSSTAATSQIGFEAPSPQGQSAALGSGGGADPEPARHVFSFSWLNSLNE
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays an important role in regulating cardiac development and contractility, muscle growth, metabolism, and fiber-type differentiation. Acts as a critical factor that regulates cardiomyocyte size during development in concert with TRIM63 by regulating E2F1-mediated gene expression (PubMed:23512667). Plays a role in apoptosis induction in cardiomyocytes by promoting ubiquitination of the DUSP1 phosphatase (PubMed:32463795). Promotes non-canonical NF-kappa-B signaling and B-cell-mediated immune responses by mediating NFKB2 'Lys-48'-linked ubiquitination and processing. In turn, NFKB2 is further processed by valosin-containing protein/VCP, an ATPase that mediates ubiquitin-dependent protein degradation by the proteasome (PubMed:37816088). May play a role in preventing macrophages from producing inflammatory factors and migrating by down-regulating the level of nuclear NF-kappa-B subunit RELA (PubMed:29435413). Modifies also PPARG via polyubiquitination and accelerates PPARG proteasomal degradation to inhibit its activity (By similarity). {ECO:0000250|UniProtKB:Q9BYV6, ECO:0000269|PubMed:23512667, ECO:0000269|PubMed:29435413, ECO:0000269|PubMed:32463795, ECO:0000269|PubMed:37816088}.
uniprot
proteins
mass_dalton
60138
uniprot
proteins
post_translational_modification
PTM: Targeted for degradation through the proteasomal and lysosomal pathways in the presence of SUMO3. {ECO:0000250|UniProtKB:Q9BYV6}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23512667
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
29435413
uniprot
proteins
pubmed
32463795
uniprot
proteins
pubmed
37816088
uniprot
proteins
sequence_length
545
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29435413}. Cytoplasm {ECO:0000269|PubMed:29435413}. Note=TLR4 signaling pathway promotes nuclear translocation. {ECO:0000269|PubMed:29435413}.
uniprot
proteins