Itm2c
entrez
64294
canonical
uniprot
Q91VK4
canonical
ensembl
ENSMUSG00000026223
resolver
ensp
ENSMUSP00000027425
resolver
enst
ENSMUST00000027425
resolver
genesymbol
Itm2c
resolver
uniprot
Q9JI06
resolver
uniprot
Q9JME8
resolver
uniprot_entry
ITM2C_MOUSE
resolver
uniprot_sec
Q9JI06
resolver
uniprot_sec
Q9JME8
resolver
amino_acid_sequence
MVKISFQPAVAGIKADKADKAAASGPASASAPAAEILLTPAREERPPRHRSRKGGSVGGVCYLSMGMVVLLMGLVFASVYIYRYFFLAQLARDNFFHCGVLYEDSLSSQIRTRLELEEDVKIYLEENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFWELLMNVKRGTYLPQTYIIQEEMVVTEHVRDKEALGSFIYHLCNGKDTYRLRRRSTRRRINKRGGKNCNAIRHFENTFVVETLICGVV
uniprot
proteins
function
FUNCTION: Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. {ECO:0000269|PubMed:14592447}.
uniprot
proteins
mass_dalton
30482
uniprot
proteins
post_translational_modification
PTM: Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembrane cleavage by SPPL2B (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
ITM2 family
uniprot
proteins
pubmed
10679242
uniprot
proteins
pubmed
11290423
uniprot
proteins
pubmed
11804340
uniprot
proteins
pubmed
14592447
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15606899
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:14592447}; Single-pass type II membrane protein {ECO:0000269|PubMed:14592447}. Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 57..77; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins