Trim14
entrez
74735
canonical
uniprot
Q8BVW3
canonical
ensembl
ENSMUSG00000039853
resolver
ensp
ENSMUSP00000038719
resolver
genesymbol
Trim14
resolver
genesymbol_syn
Kiaa0129
resolver
genesymbol_syn
Pub
resolver
uniprot
B1AVH3
resolver
uniprot
Q14AR3
resolver
uniprot
Q3TA17
resolver
uniprot
Q3V0E0
resolver
uniprot
Q6A0C3
resolver
uniprot
Q762I6
resolver
uniprot
Q9D3G8
resolver
uniprot_entry
Q14AR3_MOUSE
resolver
uniprot_entry
Q3TA17_MOUSE
resolver
uniprot_entry
Q3V0E0_MOUSE
resolver
uniprot_entry
TRI14_MOUSE
resolver
uniprot_sec
B1AVH3
resolver
uniprot_sec
Q6A0C3
resolver
uniprot_sec
Q762I6
resolver
uniprot_sec
Q9D3G8
resolver
amino_acid_sequence
MASETTEARAPFQPDGAYGWRCPEHSERPAELFCRRCGRCVCALCPVLGAHRGHPVGLAEEEAVRVQKLIQDCLECLATKKRQHADNIAHLEDAGERLKVYADSSKAWLTQKFTELRLLLDEEEVLAKKFIDKSTQLTLQVYREQAETCGKQIEVMDDFSTRVWGIGQEPNPVQLLQAYIATKTEMGQQMSPSELSHPVPLSFEPVKNFFKEFVEAIGNTLQTPMDTRLKENINCQLSNSSSTKPGALLKTSPSPERALFLKYARTPTLDPDTMHARLRLSPDGLTVRCSLLGRLGPRPAPRFDALRQVLGRDGFAAGRHYWEVDVQEAGVGWWVGAAYPSLRRRGASAAARLGCNRESWCVKRYDLEYWAFHDGQRSRLRPRRDPHRLGVFLDYEAGILAFYDVAGGMSHLHTFHAAFQEPLYPALRLWEGPISIPRLP
uniprot
proteins
function
FUNCTION: Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593). Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (PubMed:14592421). Also inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3. Mechanistically, recruits USP14 to remove the 'Lys-63'-linked ubiquitination of KDM4D, preventing its recognition by OPTN and subsequent degradation (PubMed:35145029). {ECO:0000250|UniProtKB:Q14142, ECO:0000269|PubMed:14592421, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:35145029}.; FUNCTION: Plays an essential role in the innate immune defense against viruses and bacteria. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593). Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression. Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (PubMed:14592421). {ECO:0000250|UniProtKB:Q14142, ECO:0000269|PubMed:14592421, ECO:0000269|PubMed:27666593}.
uniprot
proteins
mass_dalton
49641
uniprot
proteins
mutagenesis
MUTAGEN 51; /note="H->N: Loss of inhibition of SPI1-mediated transcriptional activation."; /evidence="ECO:0000269|PubMed:14592421
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Undergoes 'Lys-63'-linked polyubiquitination; this modification allows IKBKG/NEMO recruitment to MAVS. Undergoes 'Lys-48'-linked polyubiquitination by RNF125; this modification mediates its degradation via the ubiquitin-proteasome pathway. {ECO:0000250|UniProtKB:Q14142}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
14592421
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27666593
uniprot
proteins
pubmed
35145029
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q14142}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q14142}.
uniprot
proteins