TMEM35A
entrez
59353
canonical
uniprot
Q53FP2
canonical
ensembl
ENSG00000126950
resolver
ensp
ENSP00000362021
resolver
enst
ENST00000372930
resolver
genesymbol
TMEM35A
resolver
genesymbol_syn
NACHO
resolver
genesymbol_syn
TMEM35
resolver
hgnc
HGNC:25864
resolver
uniprot
Q9H7Y3
resolver
uniprot_entry
NACHO_HUMAN
resolver
uniprot_sec
Q9H7Y3
resolver
amino_acid_sequence
MASPRTVTIVALSVALGLFFVFMGTIKLTPRLSKDAYSEMKRAYKSYVRALPLLKKMGINSILLRKSIGALEVACGIVMTLVPGRPKDVANFFLLLLVLAVLFFHQLVGDPLKRYAHALVFGILLTCRLLIARKPEDRSSEKKPLPGNAEEQPSLYEKAPQGKVKVS
uniprot
proteins
function
FUNCTION: Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (PubMed:26875622, PubMed:27789755, PubMed:28445721, PubMed:32204458, PubMed:32783947). Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (PubMed:26875622, PubMed:27789755, PubMed:28445721, PubMed:32204458, PubMed:32783947). Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (PubMed:28445721). Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (PubMed:32676916). {ECO:0000250|UniProtKB:Q9D328, ECO:0000269|PubMed:26875622, ECO:0000269|PubMed:27789755, ECO:0000269|PubMed:28445721, ECO:0000269|PubMed:32204458, ECO:0000269|PubMed:32676916, ECO:0000269|PubMed:32783947}.
uniprot
proteins
mass_dalton
18440
uniprot
proteins
protein_family
DoxX family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
26875622
uniprot
proteins
pubmed
27789755
uniprot
proteins
pubmed
28445721
uniprot
proteins
pubmed
32204458
uniprot
proteins
pubmed
32676916
uniprot
proteins
pubmed
32783947
uniprot
proteins
sequence_length
167
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250|UniProtKB:Q9D328}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q6JAM9}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D328}; Multi-pass membrane protein {ECO:0000255}. Note=Shedding may lead to a soluble peptide. {ECO:0000250|UniProtKB:Q6JAM9}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 89..109; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 115..132; /note="Helical; Name=4"; /evidence="ECO:0000255
uniprot
proteins