IPMK
entrez
253430
canonical
uniprot
Q8NFU5
canonical
ensembl
ENSG00000151151
resolver
ensp
ENSP00000363046
resolver
enst
ENST00000373935
resolver
genesymbol
IPMK
resolver
genesymbol_syn
IMPK
resolver
hgnc
HGNC:20739
resolver
uniprot_entry
IPMK_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by flavonoids that occupy the ATP-binding pocket. Inhibited by myricetin, quercetin, luteolin, kaempferol, isorhamnetin and diosmetin, and to a lesser degree by rhamnetin and apigenin. {ECO:0000269|PubMed:30624931}.
uniprot
proteins
amino_acid_sequence
MATEPPSPLRVEAPGPPEMRTSPAIESTPEGTPQPAGGRLRFLNGCVPLSHQVAGHMYGKDKVGILQHPDGTVLKQLQPPPRGPRELEFYNMVYAADCFDGVLLELRKYLPKYYGIWSPPTAPNDLYLKLEDVTHKFNKPCIMDVKIGQKSYDPFASSEKIQQQVSKYPLMEEIGFLVLGMRVYHVHSDSYETENQHYGRSLTKETIKDGVSRFFHNGYCLRKDAVAASIQKIEKILQWFENQKQLNFYASSLLFVYEGSSQPTTTKLNDRTLAEKFLSKGQLSDTEVLEYNNNFHVLSSTANGKIESSVGKSLSKMYARHRKIYTKKHHSQTSLKVENLEQDNGWKSMSQEHLNGNVLSQLEKVFYHLPTGCQEIAEVEVRMIDFAHVFPSNTIDEGYVYGLKHLISVLRSILDN
uniprot
proteins
ec_number
2.7.1.140
uniprot
proteins
ec_number
2.7.1.151
uniprot
proteins
ec_number
2.7.1.153
uniprot
proteins
function
FUNCTION: Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:28882892, PubMed:30420721). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity). {ECO:0000250|UniProtKB:Q7TT16, ECO:0000269|PubMed:12027805, ECO:0000269|PubMed:12223481, ECO:0000269|PubMed:28882892, ECO:0000269|PubMed:29883610, ECO:0000269|PubMed:30420721, ECO:0000269|PubMed:30624931}.
uniprot
proteins
mass_dalton
47222
uniprot
proteins
mutagenesis
MUTAGEN 2..69; /note="Missing: No effect on affinity for phosphatidylinositol 4,5-bisphosphate and mildly increased enzyme activity; when associated with 279-S--V-365 DEL and 366-G--S-373."; /evidence="ECO:0000269|PubMed:30420721"; MUTAGEN 78; /note="Q->A: Strongly decreased enzyme activity."; /evidence="ECO:0000269|PubMed:28882892"; MUTAGEN 82; /note="R->A: Strongly decreased enzyme activity."; /evidence="ECO:0000269|PubMed:28882892"; MUTAGEN 144; /note="D->N: Loss of kinase activity and ability to execute necroptosis; when associated with A-146."; /evidence="ECO:0000269|PubMed:29883610"; MUTAGEN 146; /note="K->A: Loss of kinase activity and ability to execute necroptosis; when associated with N-144."; /evidence="ECO:0000269|PubMed:29883610"; MUTAGEN 160; /note="K->A: Strongly decreased enzyme activity."; /evidence="ECO:0000269|PubMed:28882892"; MUTAGEN 163; /note="Q->A: Moderately decreased enzyme activity."; /evidence="ECO:0000269|PubMed:28882892"; MUTAGEN 163; /note="Q->R: Decreased activity with inositol 1,4,5-trisphosphate. No effect on phosphorylation of inositol 1,3,4,5-tetrakisphosphate."; /evidence="ECO:0000269|PubMed:28882892"; MUTAGEN 164; /note="Q->A: Strongly decreased enzyme activity."; /evidence="ECO:0000269|PubMed:28882892"; MUTAGEN 164; /note="Q->R: Decreased activity with inositol 1,4,5-trisphosphate. Increased phosphorylation of inositol 1,3,4,5-tetrakisphosphate."; /evidence="ECO:0000269|PubMed:28882892"; MUTAGEN 167; /note="K->A: Decreased enzyme activity."; /evidence="ECO:0000269|PubMed:28882892"; MUTAGEN 196; /note="Q->A: Decreased enzyme activity."; /evidence="ECO:0000269|PubMed:28882892"; MUTAGEN 196; /note="Q->R: Decreased activity with inositol 1,4,5-trisphosphate. Increased phosphorylation of inositol 1,3,4,5-tetrakisphosphate."; /evidence="ECO:0000269|PubMed:28882892"; MUTAGEN 279..365; /note="Missing: No effect on affinity for phosphatidylinositol 4,5-bisphosphate and mildly increased enzyme activity; when associated with 2-A--P-69 DEL and 366-G--S-373 DEL."; /evidence="ECO:0000269|PubMed:30420721"; MUTAGEN 322..323; /note="RK->QQ: Interferes with nuclear localization."; /evidence="ECO:0000269|PubMed:12027805"; MUTAGEN 327..328; /note="KK->QQ: Interferes with nuclear localization."; /evidence="ECO:0000269|PubMed:12027805"; MUTAGEN 366..373; /note="FYHLPTGC->GGGGSGGGGS: No effect on affinity for phosphatidylinositol 4,5-bisphosphate and mildly increased enzyme activity; when associated with 2-A--P-69 DEL and 279-S--V-365 DEL."; /evidence="ECO:0000269|PubMed:30420721"; MUTAGEN 388; /note="H->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:28882892
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylinositol metabolism. {ECO:0000269|PubMed:12027805, ECO:0000269|PubMed:12223481, ECO:0000269|PubMed:28882892, ECO:0000269|PubMed:30624931}.
uniprot
proteins
protein_family
Inositol phosphokinase (IPK) family
uniprot
proteins
pubmed
12027805
uniprot
proteins
pubmed
12223481
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28882892
uniprot
proteins
pubmed
29883610
uniprot
proteins
pubmed
30420721
uniprot
proteins
pubmed
30624931
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12027805}.
uniprot
proteins