Mcam
entrez
84004
canonical
uniprot
Q8R2Y2
canonical
ensembl
ENSMUSG00000032135
resolver
ensp
ENSMUSP00000034650
resolver
ensp
ENSMUSP00000096451
resolver
ensp
ENSMUSP00000284857
resolver
genesymbol
Mcam
resolver
genesymbol_syn
Muc18
resolver
uniprot
Q9EPF1
resolver
uniprot
Q9ESS7
resolver
uniprot
Q9JHQ2
resolver
uniprot
Q9JHQ3
resolver
uniprot_entry
MUC18_MOUSE
resolver
uniprot_sec
Q9EPF1
resolver
uniprot_sec
Q9ESS7
resolver
uniprot_sec
Q9JHQ2
resolver
uniprot_sec
Q9JHQ3
resolver
amino_acid_sequence
MGLPKLVCVFLFAACCCCRRAAGVPGEEKQPVPTPDLVEAEVGSTALLKCGPSRASGNFSQVDWFLIHKERQILIFRVHQGKGQREPGEYEHRLSLQDSVATLALSHVTPHDERMFLCKSKRPRLQDHYVELQVFKAPEEPTIQANVVGIHVDRQELREVATCVGRNGYPIPQVLWYKNSLPLQEEENRVHIQSSQIVESSGLYTLKSVLSARLVKEDKDAQFYCELSYRLPSGNHMKESKEVTVPVFYPAEKVWVEVEPVGLLKEGDHVTIRCLTDGNPQPHFTINKKDPSTGEMEEESTDENGLLSLEPAEKHHSGLYQCQSLDLETTITLSSDPLELLVNYVSDVQVNPTAPEVQEGESLTLTCEAESNQDLEFEWLRDKTGQLLGKGPVLQLNNVRREAGGRYLCMASVPRVPGLNRTQLVSVGIFGSPWMALKERKVWVQENAVLNLSCEASGHPQPTISWNVNGSATEWNPDPQTVVSTLNVLVTPELLETGAECTASNSLGSNTTTIVLKLVTLTTLIPDSSQTTGLSTLTVSPHTRANSTSTEKKLPQPESKGVVIVAVIVCTLVLAVLGAALYFFYKKGKLPCGRSGKQEITLPPTRKSEFVVEVKSDKLPEEMALLQGSNGDKRAPGDQGEKYIDLRH
uniprot
proteins
function
FUNCTION: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
71545
uniprot
proteins
pubmed
11255016
uniprot
proteins
pubmed
11329371
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
648
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 564..584; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins