POLR3H
entrez
171568
canonical
uniprot
Q9Y535
canonical
ensembl
ENSG00000100413
resolver
ensp
ENSP00000337627
resolver
ensp
ENSP00000347345
resolver
ensp
ENSP00000379761
resolver
ensp
ENSP00000385315
resolver
ensp
ENSP00000395674
resolver
enst
ENST00000431534
resolver
genesymbol
POLR3H
resolver
genesymbol_syn
KIAA1665
resolver
genesymbol_syn
RPC8
resolver
hgnc
HGNC:30349
resolver
uniprot
B0QYH9
resolver
uniprot
F8WDV1
resolver
uniprot
Q5M7Y8
resolver
uniprot
Q96AE3
resolver
uniprot
Q9BY95
resolver
uniprot_entry
F8WDV1_HUMAN
resolver
uniprot_entry
RPC8_HUMAN
resolver
uniprot_sec
B0QYH9
resolver
uniprot_sec
Q5M7Y8
resolver
uniprot_sec
Q96AE3
resolver
uniprot_sec
Q9BY95
resolver
amino_acid_sequence
MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVFPGDGASHTKVHFRCVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKFDEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSADATTSSEELPKKEAPYTLVGSISEPGLGLLSWWTSN
uniprot
proteins
function
FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With CRCP/RPC9 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity) (PubMed:33558764, PubMed:34675218). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250, ECO:0000250|UniProtKB:O94285, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:34675218}.
uniprot
proteins
mass_dalton
22918
uniprot
proteins
protein_family
Eukaryotic RPB7/RPC8 RNA polymerase subunit family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11258795
uniprot
proteins
pubmed
12391170
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19609254
uniprot
proteins
pubmed
19631370
uniprot
proteins
pubmed
20413673
uniprot
proteins
pubmed
33335104
uniprot
proteins
pubmed
33558764
uniprot
proteins
pubmed
33558766
uniprot
proteins
pubmed
33674783
uniprot
proteins
pubmed
34675218
uniprot
proteins
sequence_length
204
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33335104}.
uniprot
proteins