Hsd3b1
entrez
360348
canonical
uniprot
P22071
canonical
ensembl
ENSRNOG00060014579
resolver
ensembl
ENSRNOG00065032855
resolver
ensp
ENSRNOP00060019844
resolver
ensp
ENSRNOP00065046456
resolver
enst
ENSRNOT00060024911
resolver
enst
ENSRNOT00065056477
resolver
genesymbol
Hsd3b1
resolver
uniprot
Q19P43
resolver
uniprot_entry
3BHS1_RAT
resolver
uniprot_sec
Q19P43
resolver
amino_acid_sequence
MPGWSCLVTGAGGFVGQRIIRMLVQEKELQEVRALDKVFRPETKEEFSKLQTKAKVTMLEGDILDAQYLRRACQGISVVIHTAAVIDVSHVLPRQTILDVNLKGTQNILEACVEASVPAFIYCSTVDVAGPNSYKKIILNGHEEEHHESTWSDAYPYSKRMAEKAVLAANGSILKNGGTLHTCALRPMYIYGERSPFLSVMILAALKNKGILNVTGKFSIANPVYVGNVAWAHILAARGLRDPKKSQNVQGQFYYISDDTPHQSYDDLNCTLSKEWGLRLDSSWSLPLPLLYWLAFLLETVSFLLRPFYNYRPPFNCHLVTLSNSKFTFSYKKAQRDLGYVPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ
uniprot
proteins
ec_number
1.1.1.145
uniprot
proteins
ec_number
1.1.1.210
uniprot
proteins
ec_number
1.1.1.270
uniprot
proteins
ec_number
5.3.3.1
uniprot
proteins
function
FUNCTION: A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone (PubMed:1537836, PubMed:1985917). Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone (PubMed:1537836). Expected to use NAD(+) as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable). {ECO:0000269|PubMed:1537836, ECO:0000269|PubMed:1985917, ECO:0000305|PubMed:1537836}.
uniprot
proteins
mass_dalton
42037
uniprot
proteins
pathway_participation
PATHWAY: Steroid hormone biosynthesis. {ECO:0000269|PubMed:1537836}.; PATHWAY: Steroid metabolism. {ECO:0000269|PubMed:1537836}.
uniprot
proteins
protein_family
3-beta-HSD family
uniprot
proteins
pubmed
1537836
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1955079
uniprot
proteins
pubmed
1985917
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 288..308; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins