Gpat2
entrez
215456
canonical
uniprot
Q14DK4
canonical
ensembl
ENSMUSG00000046338
resolver
ensp
ENSMUSP00000049619
resolver
ensp
ENSMUSP00000269375
resolver
ensp
ENSMUSP00000269376
resolver
ensp
ENSMUSP00000332065
resolver
ensp
ENSMUSP00000332067
resolver
ensp
ENSMUSP00000332072
resolver
genesymbol
Gpat2
resolver
genesymbol_syn
xGPAT1-v1
resolver
genesymbol_syn
xGPAT1-v2
resolver
uniprot
B1AW16
resolver
uniprot
Q0KK35
resolver
uniprot
Q0KK60
resolver
uniprot
Q14CH8
resolver
uniprot
Q6KAQ3
resolver
uniprot
Q8BRZ9
resolver
uniprot_entry
GPAT2_MOUSE
resolver
uniprot_entry
Q0KK35_MOUSE
resolver
uniprot_sec
B1AW16
resolver
uniprot_sec
Q0KK60
resolver
uniprot_sec
Q14CH8
resolver
uniprot_sec
Q6KAQ3
resolver
uniprot_sec
Q8BRZ9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethylmaleimide (NEM). {ECO:0000269|PubMed:17689486}.
uniprot
proteins
amino_acid_sequence
MDTMLKSNPQTQQRSNHNGQETSLWSSSFGMKMEAITPFLGKYRPFMGRCCQTCTPKSWESLFHRSIMDLGFCNVILVKEENTRFRGWLVRRLCYFLWSLEQHIPTSFDASQKIMENTGVQNLLSGRVPGAAGEGQAPELVKKEVQRILGHIQTTPRPFLLRLFSWALLWFLNRLFLNVQLHKGQMKMVQKAVQEGSPLVFLSTHKSLLDGFLLPFVLFSQGLGVVRVALDSRTCSPALRALLRKLGGLFLPPEVNLSLDNSEGILARAVVRATVEELLTSGQPLLIFLEEPPGSPGPRLSALGQAWLGVVIQAVQAGIISDATLVPVAIAYDLVPDAPCNMNHDLAPLGLWTGALAVFRRLCNCWGCNRRVCVRVHLAQPFSLQEYTINARSCWDSRQTLEHLLQPIVLGECSVVPDTEKEQEWTPPTGLLLALKEEDQLLVRRLSRHVLSASVASSAVMSTAIMATLLLLKHQKGVVLSQLLGEFSWLTEETLLRGFDVGFSGQLRCLAQHTLSLLRAHVVLLRVHQGDLVVVPRPGPGLTHLARLSMELLPTFLSEAVGACAVRGLLAGRVPPEGPWELQGIELLSQNELYRQILLLLHLLPQDLLLPQPCQSSYCYCQEVLDRLIQCGLLVAEETPGSRPACDTGRQHLSAKLLWKPSGDFTDSESDDFEEPGGRCFRLSQQSRCPDFFLFLCRLLSPILKAFAQAATFLHLGQLPDSEVAYSEKLFQFLQACAQEEGIFECADPNLAISAVWTFKDLGVLQEMPSPTGPQLHLSPTFATRDNQDKLEQFIRQFICS
uniprot
proteins
ec_number
2.3.1.15
uniprot
proteins
ec_number
2.3.1.51
uniprot
proteins
function
FUNCTION: Transfers an acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate producing a lysophosphatidic acid (LPA), an essential step for the triacylglycerol (TAG) and glycerophospholipids (PubMed:17013544, PubMed:17689486, PubMed:22905194). In vitro also transfers an acyl-group from acyl-ACP to the LPA producing a phosphatidic acid (PA) (PubMed:22905194). Prefers arachidonoyl-CoA as the acyl donor (PubMed:22905194). Required for primary processing step during piRNA biosynthesis (PubMed:23611983). Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity (PubMed:23611983). {ECO:0000269|PubMed:17013544, ECO:0000269|PubMed:17689486, ECO:0000269|PubMed:22905194, ECO:0000269|PubMed:23611983}.
uniprot
proteins
mass_dalton
89150
uniprot
proteins
mutagenesis
MUTAGEN 205; /note="H->G: Does not affect ability to promote piRNA biosynthesis."; /evidence="ECO:0000269|PubMed:23611983"; MUTAGEN 210; /note="D->G: Does not affect ability to promote piRNA biosynthesis."; /evidence="ECO:0000269|PubMed:23611983
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. {ECO:0000269|PubMed:22905194}.
uniprot
proteins
protein_family
GPAT/DAPAT family
uniprot
proteins
pubmed
15449545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17013544
uniprot
proteins
pubmed
17689486
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22285183
uniprot
proteins
pubmed
22905194
uniprot
proteins
pubmed
23611983
uniprot
proteins
pubmed
26268560
uniprot
proteins
sequence_length
801
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:17013544, ECO:0000269|PubMed:17689486, ECO:0000269|PubMed:22285183}; Multi-pass membrane protein {ECO:0000269|PubMed:17013544, ECO:0000269|PubMed:17689486, ECO:0000269|PubMed:22285183}.
uniprot
proteins
transmembrane_region
TRANSMEM 306..332; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 450..472; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins