Trak1
entrez
67095
canonical
uniprot
Q6PD31
canonical
ensembl
ENSMUSG00000032536
resolver
ensp
ENSMUSP00000044482
resolver
ensp
ENSMUSP00000148026
resolver
ensp
ENSMUSP00000148092
resolver
enst
ENSMUST00000210636
resolver
enst
ENSMUST00000211439
resolver
genesymbol
Trak1
resolver
uniprot
A0A1B0GSQ2
resolver
uniprot
A0A1B0GSV9
resolver
uniprot
Q80VE1
resolver
uniprot
Q8BYA3
resolver
uniprot_entry
A0A1B0GSQ2_MOUSE
resolver
uniprot_entry
A0A1B0GSV9_MOUSE
resolver
uniprot_entry
Q80VE1_MOUSE
resolver
uniprot_entry
TRAK1_MOUSE
resolver
uniprot_sec
Q8BYA3
resolver
amino_acid_sequence
MALAIQLRQPSRAQPLPGLSHTLAGTDSCDVCNSTNLPEVEIISLLEEQLPHYKLRADTIYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEACQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKSCAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEELESPDITHQKRVFETVRNVNQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDVSNVVLDNKTNSILLETEAADLGNEDHNKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLRELAEKGELHSGSLTPTESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLAGLATSTPIQHPETSAHHPGKCMSQTNSTFTFTTCRILHPSDELTRVTPSLNSAPAPACSSTSHLKSTPVATPCTPRRLSLAESFTNVRESTTTMSTSLGLVWLLKERGISAAVYDPQSWDRAGRGSLLHSYTPRMAVIPSTPPNSPMQTPSASPPSFEFKCTSPPYNNFLASKPASSILREVREKRPVRSSESQTDVSVSNLNLVDKVRRFGVARVVNSGRARIPTLTEEQGPLLCGPTGPAQALVPGGLVPEGLPLGCPSGIRRNRSFPTMVGSSVQMRAPVILTSGILMGAKLPKQTSLR
uniprot
proteins
disease_involvement
DISEASE: Note=A spontaneous mutation (hyrt mice) causes a recessively transmitted form of hypertonia neurological dysfunction characterized by postural abnormalities, jerky movements and tremormutant. Hyrt mice have much lower levels of GABA(A) receptors in the CNS, particularly the lower motor neurons, than do wild-type mice, indicating that the hypertonicity of the mutants is likely to be caused by deficits in GABA-mediated motor neuron inhibition. {ECO:0000269|PubMed:16380713}.
uniprot
proteins
function
FUNCTION: Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (By similarity). Involved in mitochondrial motility (PubMed:24995978). When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (By similarity). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). {ECO:0000250|UniProtKB:Q960V3, ECO:0000250|UniProtKB:Q9UPV9, ECO:0000269|PubMed:24995978}.
uniprot
proteins
mass_dalton
104467
uniprot
proteins
post_translational_modification
PTM: O-glycosylated (PubMed:24995978). Glycosylated by OGT; glycosylation in response to increased extracellular glucose levels is required for and leads to regulation of mitochondrial motility by OGT (By similarity). {ECO:0000250|UniProtKB:Q9UPV9, ECO:0000269|PubMed:24995978}.
uniprot
proteins
protein_family
Milton family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16380713
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24995978
uniprot
proteins
sequence_length
939
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24995978}. Nucleus {ECO:0000250|UniProtKB:Q9UPV9}. Mitochondrion {ECO:0000250|UniProtKB:Q9UPV9}. Early endosome {ECO:0000250|UniProtKB:Q9UPV9}. Endosome {ECO:0000250|UniProtKB:Q9UPV9}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q9UPV9}. Cytoplasm, cell cortex {ECO:0000269|PubMed:24995978}. Note=Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HGS/HRS. Colocalizes with MGARP at the mitochondria. {ECO:0000250|UniProtKB:Q9UPV9}.
uniprot
proteins