S1pr1
entrez
13609
canonical
uniprot
O08530
canonical
ensembl
ENSMUSG00000045092
resolver
ensp
ENSMUSP00000050897
resolver
enst
ENSMUST00000055676
resolver
genesymbol
S1pr1
resolver
genesymbol_syn
Edg1
resolver
genesymbol_syn
Lpb1
resolver
uniprot
Q9DC35
resolver
uniprot
Q9R235
resolver
uniprot_entry
S1PR1_MOUSE
resolver
uniprot_sec
Q9DC35
resolver
uniprot_sec
Q9R235
resolver
amino_acid_sequence
MVSTSIPEVKALRSSVSDYGNYDIIVRHYNYTGKLNIGAEKDHGIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCISSLSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKTCDILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIVSCCKCPNGDSAGKFKRPIIPGMEFSRSKSDNSSHPQKDDGDNPETIMSSGNVNSSS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. {ECO:0000269|PubMed:11032855, ECO:0000269|PubMed:11230698, ECO:0000269|PubMed:11726541, ECO:0000269|PubMed:12869509, ECO:0000269|PubMed:14732704, ECO:0000269|PubMed:14737169, ECO:0000269|PubMed:19204730, ECO:0000269|PubMed:19286607, ECO:0000269|PubMed:21668976, ECO:0000269|PubMed:22951644}.
uniprot
proteins
mass_dalton
42639
uniprot
proteins
post_translational_modification
PTM: Palmitoylated by ZDHHC5. Palmitoylation is required for targeting to plasma membrane, enabling G(i) coupling. {ECO:0000250|UniProtKB:P21453}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11032855
uniprot
proteins
pubmed
11230698
uniprot
proteins
pubmed
11726541
uniprot
proteins
pubmed
12869509
uniprot
proteins
pubmed
14732704
uniprot
proteins
pubmed
14737169
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16314531
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19204730
uniprot
proteins
pubmed
19286607
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21668976
uniprot
proteins
pubmed
22951644
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
9226368
uniprot
proteins
pubmed
9931453
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P21453}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P21453}. Endosome {ECO:0000250|UniProtKB:P21453}. Membrane raft {ECO:0000250|UniProtKB:P21453}. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization. {ECO:0000250|UniProtKB:P21453}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..68; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 83..104; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 117..138; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 161..182; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 197..224; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 258..278; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 290..310; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins