Kmt5b
entrez
225888
canonical
uniprot
Q3U8K7
canonical
ensembl
ENSMUSG00000045098
resolver
ensp
ENSMUSP00000060162
resolver
ensp
ENSMUSP00000109601
resolver
ensp
ENSMUSP00000109605
resolver
ensp
ENSMUSP00000109606
resolver
ensp
ENSMUSP00000109607
resolver
ensp
ENSMUSP00000109610
resolver
ensp
ENSMUSP00000135563
resolver
ensp
ENSMUSP00000175534
resolver
ensp
ENSMUSP00000175540
resolver
ensp
ENSMUSP00000175542
resolver
ensp
ENSMUSP00000175547
resolver
ensp
ENSMUSP00000175548
resolver
ensp
ENSMUSP00000328596
resolver
ensp
ENSMUSP00000328597
resolver
genesymbol
Kmt5b
resolver
genesymbol_syn
Suv420h1
resolver
uniprot
Q3UTP6
resolver
uniprot
Q6DI74
resolver
uniprot
Q6Q784
resolver
uniprot
Q8BU67
resolver
uniprot
Q8BUN0
resolver
uniprot
Q8BUT7
resolver
uniprot
Q8BW73
resolver
uniprot
Q8BZ24
resolver
uniprot
Q91X81
resolver
uniprot_entry
KMT5B_MOUSE
resolver
uniprot_sec
Q3UTP6
resolver
uniprot_sec
Q6DI74
resolver
uniprot_sec
Q6Q784
resolver
uniprot_sec
Q8BU67
resolver
uniprot_sec
Q8BUN0
resolver
uniprot_sec
Q8BUT7
resolver
uniprot_sec
Q8BW73
resolver
uniprot_sec
Q8BZ24
resolver
uniprot_sec
Q91X81
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine (A-196). A-196 is competitive with the histone peptide substrate H4K20me1 but non competitive with S-adenosyl-L-methionine. {ECO:0000250|UniProtKB:Q4FZB7}.
uniprot
proteins
amino_acid_sequence
MKWLGDSKNMVVNGRRNGGKLSNDHQQNQSKLQQHSGKDTLKTGRNAVERRSSRCHGNSGFEGQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTSAFPSRSSRHISKADSFSHNNPVRFRPIKGRQEELKEVIERFKKDEHLEKAFKCLTSGEWARHYFLNKNKMQEKLFKEHVFIYLRMFATDSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSRVGLPAPAPVINSKYGLRETDKRLNRLKKLGDSSKNSDSQSVSSNTDADTTQEKDNATSNRKSSVGVKKSSKSRALTRPSMPRVPAASNSTSPKLVHTNNPRVPKKLRKPAKPLLSKIRLRNHCKRLDQKSASRKLEMGSLVLKEPKVVLYKNLPIKKEREPEGPAHAAVGSGCLTRHAAREHRQNHGRGAHSQGDSLPCTYTTRRSLRTRTGLKETTDIKLEPSPLDGYKNGILEPCPDSGQQPTPEVLEELAPETAHREEASQECPKNDSCLSRKKFRQVKPVKHLAKTEDCSPEHSFPGKDGLPDLPGSHPDQGEPSGTVRVPVSHTDSAPSPVGCSVVAPDSFTKDSFRTAQSKKKRRVTRYDAQLILENSSGIPKLTLRRRHDSSSKTNDHESDGVNSSKISIKLSKDHDSDSNLYVAKLSNGVSAGPGSSSTKLKIQLKRDEESRGPCAEGLHENGVCCSDPLSLLESQMEVDDYSQYEEDSTDESSSSEGEEEEEDCEDDFDDDFIPLPPAKRLRLIVGKDSIDIDISSRRREDQSLRLNA
uniprot
proteins
ec_number
2.1.1.361
uniprot
proteins
ec_number
2.1.1.362
uniprot
proteins
function
FUNCTION: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:15145825, PubMed:24049080, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (PubMed:15145825). Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions (PubMed:15145825). KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (PubMed:15750587, PubMed:16612004). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). {ECO:0000250|UniProtKB:Q4FZB7, ECO:0000269|PubMed:15145825, ECO:0000269|PubMed:15750587, ECO:0000269|PubMed:16612004, ECO:0000269|PubMed:23720823, ECO:0000269|PubMed:24049080, ECO:0000269|PubMed:28114273}.
uniprot
proteins
mass_dalton
98580
uniprot
proteins
mutagenesis
MUTAGEN 282; /note="F->Y: Loss of methyltransferase activity for H4K20me1 peptide."; /evidence="ECO:0000269|PubMed:24049080
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
protein_family
Suvar4-20 subfamily
uniprot
proteins
pubmed
15145825
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15750587
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16612004
uniprot
proteins
pubmed
23720823
uniprot
proteins
pubmed
24049080
uniprot
proteins
pubmed
28114273
uniprot
proteins
sequence_length
883
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15145825}. Chromosome {ECO:0000269|PubMed:15145825}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin.
uniprot
proteins