Scd3
entrez
30049
canonical
uniprot
Q99PL7
canonical
ensembl
ENSMUSG00000025202
resolver
ensp
ENSMUSP00000026220
resolver
genesymbol
Scd3
resolver
uniprot
Q3UWK5
resolver
uniprot
Q9D550
resolver
uniprot_entry
SCD3_MOUSE
resolver
uniprot_sec
Q3UWK5
resolver
uniprot_sec
Q9D550
resolver
amino_acid_sequence
MPGHLLQEEMTPSYTTTTTITAPPSGSLQNGREKVKTVPLYLEEDIRPEMKEDIYDPTYQDEEGPPPKLEYVWRNIILMALLHVGALYGITLVPSCKLYTCLFAFVYYVISIEGIGAGVHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGILLMCFILPTLVPWYCWGETFLNSFYVATLLRYAVVLNATWLVNSAAHLYGYRPYDKNIDPRQNALVSLGSMGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKRVSKATVLARIKRTGDGSHKSG
uniprot
proteins
ec_number
1.14.19.-
uniprot
proteins
function
FUNCTION: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA (PubMed:16443825, PubMed:26098370). Has a strong preference for saturated fatty acids with chain lengths of 14 or 16 carbon atoms (C14:0 and C16:0), and has only very low activity with stearatate (C18:0) (PubMed:16443825, PubMed:26098370). Required for the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). {ECO:0000250|UniProtKB:O00767, ECO:0000269|PubMed:16443825, ECO:0000269|PubMed:26098370}.
uniprot
proteins
mass_dalton
41432
uniprot
proteins
mutagenesis
MUTAGEN 112..113; /note="IE->AL: Changes substrate specificity so that stearate becomes a good substrate.
uniprot
proteins
protein_family
Fatty acid desaturase type 1 family
uniprot
proteins
pubmed
11161812
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16118274
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16443825
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26098370
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O00767}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O00767}. Microsome membrane {ECO:0000269|PubMed:16443825}.
uniprot
proteins
transmembrane_region
TRANSMEM 73..93; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O00767"; TRANSMEM 98..118; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O00767"; TRANSMEM 218..237; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O00767"; TRANSMEM 242..263; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O00767
uniprot
proteins