Il6ra
entrez
16194
canonical
uniprot
P22272
canonical
ensembl
ENSMUSG00000027947
resolver
ensp
ENSMUSP00000029559
resolver
ensp
ENSMUSP00000143541
resolver
enst
ENSMUST00000029559
resolver
enst
ENSMUST00000197679
resolver
genesymbol
Il6ra
resolver
genesymbol_syn
Il6r
resolver
uniprot
A0A0G2JGF1
resolver
uniprot
Q3URV7
resolver
uniprot_entry
A0A0G2JGF1_MOUSE
resolver
uniprot_entry
IL6RA_MOUSE
resolver
uniprot_entry
Q3URV7_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Classic and trans-signaling are both inhibited by tocilizumab, a humanized monoclonal antibody that blocks interleukin IL6R signaling. {ECO:0000250|UniProtKB:P08887}.
uniprot
proteins
amino_acid_sequence
MLTVGCTLLVALLAAPAVALVLGSCRALEVANGTVTSLPGATVTLICPGKEAAGNVTIHWVYSGSQNREWTTTGNTLVLRDVQLSDTGDYLCSLNDHLVGTVPLLVDVPPEEPKLSCFRKNPLVNAICEWRPSSTPSPTTKAVLFAKKINTTNGKSDFQVPCQYSQQLKSFSCQVEILEGDKVYHIVSLCVANSVGSKSSHNEAFHSLKMVQPDPPANLVVSAIPGRPRWLKVSWQHPETWDPSYYLLQFQLRYRPVWSKEFTVLLLPVAQYQCVIHDALRGVKHVVQVRGKEELDLGQWSEWSPEVTGTPWIAEPRTTPAGILWNPTQVSVEDSANHEDQYESSTEATSVLAPVQESSSMSLPTFLVAGGSLAFGLLLCVFIILRLKQKWKSEAEKESKTTSPPPPPYSLGPLKPTFLLVPLLTPHSSGSDNTVNHSCLGVRDAQSPYDNSNRDYLFPR
uniprot
proteins
function
FUNCTION: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. {ECO:0000305|PubMed:30995492}.; FUNCTION: [Interleukin-6 receptor subunit alpha]: Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory (Probable). Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells (PubMed:27893700). {ECO:0000269|PubMed:27893700, ECO:0000305|PubMed:30995492}.; FUNCTION: [Soluble interleukin-6 receptor subunit alpha]: Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed:11113088). The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (By similarity). In complex with IL6, is required for induction of VEGF production (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (PubMed:11113088). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (PubMed:28402851). {ECO:0000250|UniProtKB:P08887, ECO:0000269|PubMed:11113088, ECO:0000269|PubMed:28402851}.
uniprot
proteins
mass_dalton
50455
uniprot
proteins
post_translational_modification
PTM: A short soluble form is also released from the membrane by proteolysis (PubMed:26876177). The sIL6R is formed by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding (PubMed:26876177). mIL6R is cleaved by the proteases ADAM10 and ADAM17 (PubMed:26876177). {ECO:0000269|PubMed:26876177}.; PTM: Glycosylated. Glycosylation is dispensable for transport, signaling, and cell-surface turnover. Glycosylation at Asn-55 is a protease-regulatory exosite. Glycosylation is required for ADAM17-mediated proteolysis. {ECO:0000250|UniProtKB:P08887}.
uniprot
proteins
protein_family
Type 3 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
11113088
uniprot
proteins
pubmed
2112585
uniprot
proteins
pubmed
26876177
uniprot
proteins
pubmed
27893700
uniprot
proteins
pubmed
28265003
uniprot
proteins
pubmed
28402851
uniprot
proteins
pubmed
30995492
uniprot
proteins
sequence_length
460
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Interleukin-6 receptor subunit alpha]: Cell membrane {ECO:0000269|PubMed:27893700}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Soluble interleukin-6 receptor subunit alpha]: Secreted {ECO:0000269|PubMed:28402851}.
uniprot
proteins
transmembrane_region
TRANSMEM 365..385; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins