ITGB3BP
entrez
23421
canonical
uniprot
Q13352
canonical
ensembl
ENSG00000142856
resolver
ensp
ENSP00000271002
resolver
ensp
ENSP00000360133
resolver
ensp
ENSP00000715519
resolver
ensp
ENSP00000715523
resolver
genesymbol
ITGB3BP
resolver
genesymbol_syn
CENPR
resolver
genesymbol_syn
NRIF3
resolver
hgnc
HGNC:6157
resolver
uniprot
B2R7D8
resolver
uniprot
Q13353
resolver
uniprot
Q5RJ42
resolver
uniprot
Q5RJ44
resolver
uniprot
Q5RJ45
resolver
uniprot
Q7KYX2
resolver
uniprot
Q96CD5
resolver
uniprot
Q9UKB6
resolver
uniprot_entry
CENPR_HUMAN
resolver
uniprot_sec
B2R7D8
resolver
uniprot_sec
Q13353
resolver
uniprot_sec
Q5RJ42
resolver
uniprot_sec
Q5RJ44
resolver
uniprot_sec
Q5RJ45
resolver
uniprot_sec
Q7KYX2
resolver
uniprot_sec
Q96CD5
resolver
uniprot_sec
Q9UKB6
resolver
amino_acid_sequence
MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDNDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELENLIGISCASHFLKREMQKTKELMTKVNKQKLFEKSTGLPHKASRHLDSYEFLKAILN
uniprot
proteins
function
FUNCTION: Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:11713274, ECO:0000269|PubMed:12244126, ECO:0000269|PubMed:15082778, ECO:0000269|PubMed:15254226, ECO:0000269|PubMed:16622420}.
uniprot
proteins
mass_dalton
20194
uniprot
proteins
mutagenesis
MUTAGEN 9; /note="L->A: Decreased interaction with nuclear receptors."; /evidence="ECO:0000269|PubMed:10490654"; MUTAGEN 28; /note="S->A: Loss of repressor function."; /evidence="ECO:0000269|PubMed:11713274, ECO:0000269|PubMed:15082778"; MUTAGEN 63..66; /note="Missing: Abolishes localization to nucleus."; /evidence="ECO:0000269|PubMed:12244126"; MUTAGEN 63..65; /note="KRK->AAA: Abolishes localization to nucleus."; /evidence="ECO:0000269|PubMed:11864709"; MUTAGEN 89; /note="L->R: Abolishes dimerization, but not interactions with nuclear receptors; when associated with R-96."; /evidence="ECO:0000269|PubMed:11713274"; MUTAGEN 96; /note="L->R: Abolishes dimerization, but not interactions with nuclear receptors; when associated with R-89."; /evidence="ECO:0000269|PubMed:11713274"; MUTAGEN 172..176; /note="LKAIL->AKAAA: Abolishes interaction with nuclear receptors."; /evidence="ECO:0000269|PubMed:10490654
uniprot
proteins
pubmed
10490654
uniprot
proteins
pubmed
10673397
uniprot
proteins
pubmed
11713274
uniprot
proteins
pubmed
11864709
uniprot
proteins
pubmed
12244126
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15082778
uniprot
proteins
pubmed
15254226
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16622419
uniprot
proteins
pubmed
16622420
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
7593198
uniprot
proteins
pubmed
9182673
uniprot
proteins
sequence_length
177
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Cytoplasm. Note=Isoform 3 is predominantly nuclear and weakly cytoplasmic.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm.
uniprot
proteins