HOPX
entrez
84525
canonical
uniprot
Q9BPY8
canonical
ensembl
ENSG00000171476
resolver
ensp
ENSP00000315198
resolver
ensp
ENSP00000337330
resolver
ensp
ENSP00000370654
resolver
ensp
ENSP00000396275
resolver
ensp
ENSP00000450527
resolver
ensp
ENSP00000451794
resolver
ensp
ENSP00000452098
resolver
ensp
ENSP00000452340
resolver
ensp
ENSP00000537458
resolver
ensp
ENSP00000537459
resolver
ensp
ENSP00000537460
resolver
genesymbol
HOPX
resolver
genesymbol_syn
HOD
resolver
genesymbol_syn
HOP
resolver
genesymbol_syn
LAGY
resolver
genesymbol_syn
NECC1
resolver
genesymbol_syn
OB1
resolver
hgnc
HGNC:24961
resolver
uniprot
A8K0Z2
resolver
uniprot
E9PB55
resolver
uniprot
G3V294
resolver
uniprot
Q8N0V6
resolver
uniprot
Q96CI1
resolver
uniprot_entry
HOP_HUMAN
resolver
uniprot_sec
A8K0Z2
resolver
uniprot_sec
E9PB55
resolver
uniprot_sec
G3V294
resolver
uniprot_sec
Q8N0V6
resolver
uniprot_sec
Q96CI1
resolver
amino_acid_sequence
MSAETASGPTEDQVEILEYNFNKVDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRSEGLPSECRSVTD
uniprot
proteins
function
FUNCTION: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256). {ECO:0000250|UniProtKB:Q8R1H0, ECO:0000269|PubMed:27708256}.
uniprot
proteins
mass_dalton
8260
uniprot
proteins
pubmed
12573257
uniprot
proteins
pubmed
12759545
uniprot
proteins
pubmed
14516659
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15213722
uniprot
proteins
pubmed
15381369
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
27708256
uniprot
proteins
sequence_length
73
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8R1H0}. Cytoplasm {ECO:0000250|UniProtKB:Q8R1H0}.
uniprot
proteins