Smc5
entrez
226026
canonical
uniprot
Q8CG46
canonical
ensembl
ENSMUSG00000024943
resolver
ensp
ENSMUSP00000084837
resolver
ensp
ENSMUSP00000153364
resolver
ensp
ENSMUSP00000153420
resolver
ensp
ENSMUSP00000258770
resolver
ensp
ENSMUSP00000258771
resolver
enst
ENSMUST00000226111
resolver
genesymbol
Smc5
resolver
genesymbol_syn
Kiaa0594
resolver
genesymbol_syn
Smc5l1
resolver
uniprot
A0A286YDG5
resolver
uniprot
Q80TW7
resolver
uniprot
Q8CHX5
resolver
uniprot
Q922K3
resolver
uniprot_entry
A0A286YDG5_MOUSE
resolver
uniprot_entry
SMC5_MOUSE
resolver
uniprot_sec
Q80TW7
resolver
uniprot_sec
Q8CHX5
resolver
uniprot_sec
Q922K3
resolver
amino_acid_sequence
MATPSGKAAPPNPQVSKRSLPRDASSEVPSKRKNSNPLPTLPRPSGTFVEGSIVRIAMENFLTYDICEVSPGPHLNMIIGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVKRGCSKGLVEIELFRTSGNLIITREIDVIKNQSFWFINKKPVTQKIVEEQVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSVGPPEMHRYHCELKNFREKEKQLETSCKEKTEYLEKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEGVKLIRDRVKEEVRKLKEGQIPMTRRIEEIDRQRHTLEVRIKEKSTDIKEASQKCKQRQDLIERKDRQIKELQQALTVKQNEELDRQKRISNTRKMIEDLQSELKTAENCENLQPQIDTVTNDLRRVQEEKALCEGEIIDKQREKEMLEKQRRSVSDHITRFDNLMNQKEDKLRQRYRDTYDAVLWLRNNRDRFKQRVCEPIMLTINMKDNKNAKYVENHISSNDLRAFVFESQEDMEIFLREVRDNKKLRVNAVIAPKISYADKAPSRSLNDLKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTERTRERIERVIQETRLKQIYTAEEKYVLKTSVYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEMNRQLEAVDSGLAALRDTNRHLELKDNELRLKKKELLERKTRKRQLEQKISSKLASIRLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTGLVKICTSFQIQKVDLILQNTTVISEKNKLEADYMASSSQLRVTEQQFIELDDNRQRLLQKCKELMKKARQVCNLSADQAVPQEFQTQVPTIPNGHSSSPPMAFQDLPNTLDEIDALLTEERSRASCFTGLNPSVVEEYSKREVEIQQLTEELQGKKVELDEYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINERRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVLFVYNGPHMLEPNRWNLKAFQRRRRRITFTQPQ
uniprot
proteins
function
FUNCTION: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
128813
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000250}.; PTM: Ubiquitinated. {ECO:0000250}.
uniprot
proteins
protein_family
SMC family
uniprot
proteins
protein_family
SMC5 subfamily
uniprot
proteins
pubmed
11408570
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
14660695
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20339383
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1101
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11408570, ECO:0000269|PubMed:20339383}. Chromosome {ECO:0000269|PubMed:11408570}. Nucleus, PML body {ECO:0000250|UniProtKB:Q8IY18}. Chromosome, telomere {ECO:0000250|UniProtKB:Q8IY18}. Note=Colocalizes with SMC6 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (PubMed:11408570). Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines. Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner. {ECO:0000250|UniProtKB:Q8IY18, ECO:0000269|PubMed:11408570}.
uniprot
proteins