Cbr1
entrez
12408
canonical
uniprot
P48758
canonical
ensembl
ENSMUSG00000051483
resolver
ensp
ENSMUSP00000049394
resolver
enst
ENSMUST00000039659
resolver
genesymbol
Cbr1
resolver
genesymbol_syn
Cbr
resolver
uniprot
B2RXY7
resolver
uniprot
Q91X28
resolver
uniprot_entry
B2RXY7_MOUSE
resolver
uniprot_entry
CBR1_MOUSE
resolver
uniprot_sec
Q91X28
resolver
amino_acid_sequence
MSSSRPVALVTGANKGIGFAITRDLCRKFSGDVVLAARDEERGQTAVQKLQAEGLSPRFHQLDIDNPQSIRALRDFLLKEYGGLDVLVNNAGIAFKVNDDTPFHIQAEVTMKTNFFGTRDVCKELLPLIKPQGRVVNVSSMVSLRALKNCRLELQQKFRSETITEEELVGLMNKFVEDTKKGVHAEEGWPNSAYGVTKIGVTVLSRILARKLNEQRRGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVQDKKVEPW
uniprot
proteins
ec_number
1.1.1.184
uniprot
proteins
ec_number
1.1.1.189
uniprot
proteins
ec_number
1.1.1.196
uniprot
proteins
ec_number
1.1.1.197
uniprot
proteins
ec_number
1.1.1.71
uniprot
proteins
function
FUNCTION: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267, PubMed:33785425). {ECO:0000250|UniProtKB:P16152, ECO:0000250|UniProtKB:Q28960, ECO:0000269|PubMed:28878267, ECO:0000269|PubMed:33785425}.
uniprot
proteins
mass_dalton
30641
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28878267
uniprot
proteins
pubmed
33785425
uniprot
proteins
pubmed
8661038
uniprot
proteins
sequence_length
277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q28960}.
uniprot
proteins