Ctsl
entrez
13039
canonical
uniprot
P06797
canonical
ensembl
ENSMUSG00000021477
resolver
ensp
ENSMUSP00000021933
resolver
ensp
ENSMUSP00000152169
resolver
enst
ENSMUST00000021933
resolver
enst
ENSMUST00000222517
resolver
genesymbol
Ctsl
resolver
genesymbol_syn
Ctsl1
resolver
uniprot
Q543M3
resolver
uniprot
Q91UZ0
resolver
uniprot_entry
CATL1_MOUSE
resolver
uniprot_entry
Q543M3_MOUSE
resolver
uniprot_sec
Q91UZ0
resolver
activity_regulation
ACTIVITY REGULATION: Long isoform of CD74/Ii chain stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of APCs (PubMed:11483509, PubMed:12417635). IFNG enhances the conversion into the CTSL mature and active form (PubMed:11483509). Inhibited by CST6. Inhibited by the glycopeptide antibiotic teicoplanin. Inhibited by amantadine (By similarity). {ECO:0000250|UniProtKB:P07711, ECO:0000269|PubMed:11483509, ECO:0000269|PubMed:12417635}.
uniprot
proteins
amino_acid_sequence
MNLLLLLAVLCLGTALATPKFDQTFSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHKKGRLFQEPLMLKIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVVN
uniprot
proteins
ec_number
3.4.22.15
uniprot
proteins
function
FUNCTION: Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:12782676). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (PubMed:12869695). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells (PubMed:12021314). Also mediates invariant chain processing in cortical thymic epithelial cells (PubMed:9545226). Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (PubMed:12417635). Secreted form generates endostatin from COL18A1 (PubMed:10716919). Critical for cardiac morphology and function (PubMed:11972068). Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (PubMed:12163394). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity). {ECO:0000250|UniProtKB:P07154, ECO:0000269|PubMed:10716919, ECO:0000269|PubMed:11972068, ECO:0000269|PubMed:12021314, ECO:0000269|PubMed:12163394, ECO:0000269|PubMed:12417635, ECO:0000269|PubMed:12782676, ECO:0000269|PubMed:12869695, ECO:0000269|PubMed:9545226, ECO:0000305}.
uniprot
proteins
mass_dalton
37547
uniprot
proteins
post_translational_modification
PTM: During export along the endocytic pathway, pro-CTSL undergoes several proteolytic cleavages to generate the CTSL single-chain and two-chain mature forms, composed of a heavy chain linked to a light chain by disulfide bonds (PubMed:11483509). Autocleavage; produces the single-chain CTSL after cleavage of the propeptide. The cleavage can be intermolecular (By similarity). {ECO:0000250|UniProtKB:P07711, ECO:0000269|PubMed:11483509}.
uniprot
proteins
protein_family
Peptidase C1 family
uniprot
proteins
pubmed
10516062
uniprot
proteins
pubmed
10716919
uniprot
proteins
pubmed
11483509
uniprot
proteins
pubmed
11972068
uniprot
proteins
pubmed
12021314
uniprot
proteins
pubmed
12163394
uniprot
proteins
pubmed
12417635
uniprot
proteins
pubmed
12782676
uniprot
proteins
pubmed
12869695
uniprot
proteins
pubmed
15099520
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16170054
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2275556
uniprot
proteins
pubmed
2835398
uniprot
proteins
pubmed
3533924
uniprot
proteins
pubmed
3689328
uniprot
proteins
pubmed
3755373
uniprot
proteins
pubmed
8554545
uniprot
proteins
pubmed
9545226
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:11483509, ECO:0000269|PubMed:12782676}. Apical cell membrane {ECO:0000269|PubMed:12782676}; Peripheral membrane protein {ECO:0000269|PubMed:12782676}; Extracellular side {ECO:0000269|PubMed:12782676}. Secreted, extracellular space {ECO:0000269|PubMed:12417635}. Secreted {ECO:0000269|PubMed:10716919}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250|UniProtKB:P25975}. Note=Localizes to the apical membrane of thyroid epithelial cells. Released at extracellular space by activated dendritic cells and macrophages (PubMed:12417635). {ECO:0000269|PubMed:12417635, ECO:0000269|PubMed:12782676}.
uniprot
proteins