ERRFI1
entrez
54206
canonical
uniprot
Q9UJM3
canonical
ensembl
ENSG00000116285
resolver
ensp
ENSP00000366702
resolver
ensp
ENSP00000527174
resolver
ensp
ENSP00000527175
resolver
ensp
ENSP00000527176
resolver
ensp
ENSP00000527178
resolver
ensp
ENSP00000527180
resolver
ensp
ENSP00000527181
resolver
ensp
ENSP00000527182
resolver
ensp
ENSP00000527183
resolver
ensp
ENSP00000634047
resolver
ensp
ENSP00000634048
resolver
enst
ENST00000377482
resolver
enst
ENST00000857115
resolver
enst
ENST00000857116
resolver
enst
ENST00000857117
resolver
enst
ENST00000857119
resolver
enst
ENST00000857121
resolver
enst
ENST00000857122
resolver
enst
ENST00000857123
resolver
enst
ENST00000857124
resolver
enst
ENST00000963988
resolver
enst
ENST00000963989
resolver
genesymbol
ERRFI1
resolver
genesymbol_syn
MIG6
resolver
hgnc
HGNC:18185
resolver
uniprot
B2RDX9
resolver
uniprot
B3KTV8
resolver
uniprot
Q9NTG9
resolver
uniprot
Q9UD05
resolver
uniprot_entry
B3KTV8_HUMAN
resolver
uniprot_entry
ERRFI_HUMAN
resolver
uniprot_sec
B2RDX9
resolver
uniprot_sec
Q9NTG9
resolver
uniprot_sec
Q9UD05
resolver
amino_acid_sequence
MSIAGVAAQEIRVPLKTGFLHNGRAMGNMRKTYWSSRSEFKNNFLNIDPITMAYSLNSSAQERLIPLGHASKSAPMNGHCFAENGPSQKSSLPPLLIPPSENLGPHEEDQVVCGFKKLTVNGVCASTPPLTPIKNSPSLFPCAPLCERGSRPLPPLPISEALSLDDTDCEVEFLTSSDTDFLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDTPAVSAADLSYVSDQNGGVPDPNPPPPQTHRRLRRSHSGPAGSFNKPAIRISNCCIHRASPNSDEDKPEVPPRVPIPPRPVKPDYRRWSAEVTSSTYSDEDRPPKVPPREPLSPSNSRTPSPKSLPSYLNGVMPPTQSFAPDPKYVSSKALQRQNSEGSASKVPCILPIIENGKKVSSTHYYLLPERPPYLDKYEKFFREAEETNGGAQIQPLPADCGISSATEKPDSKTKMDLGGHVKRKHLSYVVSP
uniprot
proteins
function
FUNCTION: Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
50560
uniprot
proteins
mutagenesis
MUTAGEN 346; /note="M->A: Abolishes inhibition of EGFR activity."; /evidence="ECO:0000269|PubMed:18046415"; MUTAGEN 352; /note="F->A: Abolishes inhibition of EGFR activity."; /evidence="ECO:0000269|PubMed:18046415"; MUTAGEN 358; /note="Y->A: Abolishes inhibition of EGFR activity."; /evidence="ECO:0000269|PubMed:18046415
uniprot
proteins
protein_family
MIG6 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18046415
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7641805
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7641805}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity). {ECO:0000250}.
uniprot
proteins