Numb
entrez
18222
canonical
uniprot
Q9QZS3
canonical
ensembl
ENSMUSG00000021224
resolver
ensp
ENSMUSP00000021647
resolver
ensp
ENSMUSP00000117899
resolver
ensp
ENSMUSP00000119303
resolver
ensp
ENSMUSP00000285343
resolver
ensp
ENSMUSP00000285352
resolver
ensp
ENSMUSP00000285353
resolver
genesymbol
Numb
resolver
uniprot
P70422
resolver
uniprot
Q8CIB1
resolver
uniprot
Q9DC57
resolver
uniprot
Q9QZR1
resolver
uniprot
Q9QZS4
resolver
uniprot_entry
NUMB_MOUSE
resolver
uniprot_sec
P70422
resolver
uniprot_sec
Q8CIB1
resolver
uniprot_sec
Q9DC57
resolver
uniprot_sec
Q9QZR1
resolver
uniprot_sec
Q9QZS4
resolver
amino_acid_sequence
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQLQDAKKAETDKTVVGPSVAPGNTAPSPSSPTSPTPDGTASSEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNTVPEVEGEAESISSLCSQITSAFSTPSEDPFSSAPMTKPVTLVAPQSPVLQANGTDSASHVLTAKPANTALAHVAMPVRETNPWAHVPDAANKEIAAIHPGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQVSAAPLQPVLQPPPPAAIAPPAPPFQGHAFLTSQPVPVGVVPPLQPAFVPTQSYPVANGMPYPASNVPVVGITPSQMVANVFGTAGHPQTTHPHQSPSLAKQQTFPQYETSSATTSPFFKPPAQHLNGSAAFNGVDNGGLASGNRHAEVPPGTCPVDPFEAQWAALESKSKQRTNPSPTNPFSSDLQKTFEIEL
uniprot
proteins
function
FUNCTION: Regulates clathrin-mediated receptor endocytosis (By similarity). Plays a role in the process of neurogenesis (PubMed:10841580, PubMed:12410312, PubMed:15273690, PubMed:17174898). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (PubMed:12410312, PubMed:15273690). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis (PubMed:12410312, PubMed:15273690). Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (PubMed:17174898). May also mediate local repair of brain ventricular wall damage (PubMed:17174898). {ECO:0000250|UniProtKB:P49757, ECO:0000269|PubMed:10841580, ECO:0000269|PubMed:12410312, ECO:0000269|PubMed:15273690, ECO:0000269|PubMed:17174898}.
uniprot
proteins
mass_dalton
70813
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-276 and Ser-295 by CaMK1. {ECO:0000250}.; PTM: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation (By similarity) Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation. {ECO:0000250, ECO:0000269|PubMed:11782429}.
uniprot
proteins
pubmed
10551880
uniprot
proteins
pubmed
10841580
uniprot
proteins
pubmed
11782429
uniprot
proteins
pubmed
12410312
uniprot
proteins
pubmed
15273690
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17174898
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8755477
uniprot
proteins
pubmed
9535908
uniprot
proteins
sequence_length
653
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P49757}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49757}; Cytoplasmic side {ECO:0000250|UniProtKB:P49757}. Endosome membrane {ECO:0000250|UniProtKB:P49757}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49757}; Cytoplasmic side {ECO:0000250|UniProtKB:P49757}. Note=Localizes to perinuclear endosomes in an AAK1-dependent manner. {ECO:0000250|UniProtKB:P49757}.
uniprot
proteins