Sh2b2
entrez
114203
canonical
uniprot
Q9Z200
canonical
ensembl
ENSRNOG00000001425
resolver
ensembl
ENSRNOG00055000280
resolver
ensembl
ENSRNOG00060011903
resolver
ensp
ENSRNOP00000001935
resolver
ensp
ENSRNOP00000097265
resolver
ensp
ENSRNOP00055000334
resolver
ensp
ENSRNOP00060015809
resolver
enst
ENSRNOT00000001935
resolver
enst
ENSRNOT00000102136
resolver
enst
ENSRNOT00055000471
resolver
enst
ENSRNOT00060020136
resolver
genesymbol
Sh2b2
resolver
genesymbol_syn
Aps
resolver
uniprot
A0A8I6GLZ7
resolver
uniprot_entry
A0A8I6GLZ7_RAT
resolver
uniprot_entry
SH2B2_RAT
resolver
amino_acid_sequence
MNGATPGSAAAPAPVPDWRQFCELHAQVAAVDFAHKFCRFLRDNPTYDTPDAGTSFSRHFAANFLAVFSEEVRRVLGTAADTMEPEPAVTSVTSALKTATYGHSRSSEDVSAHVATKARVRKGFSLRNMSLCVVDGVRDLWHRRASPEPEGGATPKTTEPVSEPRDKWTRRLRLARTLAAKVELVDIQREGALRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASRVTSCSCELLTEADMPRPPETMTAVGAVVTAPHGRARDTVGESLAHVPLETFLQTLESSGGVSESNNTGDEGAELDPDAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPDPGPAPNTAAPVPACWTEPAGQHYFSSLATATCPPTSPSNGAGASSSSGSSSSATSVPPRPAEGPLSARSRSNSTEHLLEAASGATEEPADATLGRARAVENQYSFY
uniprot
proteins
function
FUNCTION: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis (By similarity). Involved in stimulation of glucose uptake by insulin. Involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Induces cytoskeletal reorganization and neurite outgrowth in cultured neurons. {ECO:0000250, ECO:0000269|PubMed:10854852, ECO:0000269|PubMed:11997497, ECO:0000269|PubMed:15031295, ECO:0000269|PubMed:9856458}.
uniprot
proteins
mass_dalton
66708
uniprot
proteins
mutagenesis
MUTAGEN 437; /note="R->A: Abolishes interaction with phosphorylated INSR."; /evidence="ECO:0000269|PubMed:14690593"; MUTAGEN 455; /note="K->A: Reduces interaction with phosphorylated INSR."; /evidence="ECO:0000269|PubMed:14690593"; MUTAGEN 457; /note="K->N: Abolishes interaction with phosphorylated INSR."; /evidence="ECO:0000269|PubMed:14690593"; MUTAGEN 618; /note="Y->F: Abolishes phosphorylation in response to insulin.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on a tyrosine residue by NTRK1, NTRK2, NTRK3 and INSR after stimulation of the receptor by its extracellular ligand. Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation with cytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
SH2B adapter family
uniprot
proteins
pubmed
10854852
uniprot
proteins
pubmed
11997497
uniprot
proteins
pubmed
14690593
uniprot
proteins
pubmed
15031295
uniprot
proteins
pubmed
15231829
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9856458
uniprot
proteins
sequence_length
621
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Membrane. Note=Recruited to the membrane by binding to an autophosphorylated receptor after receptor stimulation by its extracellular ligand.
uniprot
proteins