SH3BP5
entrez
9467
canonical
uniprot
O60239
canonical
ensembl
ENSG00000131370
resolver
ensp
ENSP00000373301
resolver
ensp
ENSP00000386231
resolver
ensp
ENSP00000388553
resolver
ensp
ENSP00000555983
resolver
genesymbol
SH3BP5
resolver
genesymbol_syn
SAB
resolver
hgnc
HGNC:10827
resolver
uniprot
B3KQW6
resolver
uniprot
Q5JWV9
resolver
uniprot_entry
3BP5_HUMAN
resolver
uniprot_sec
B3KQW6
resolver
uniprot_sec
Q5JWV9
resolver
amino_acid_sequence
MDAALKRSRSEEPAEILPPARDEEEEEEEGMEQGLEEEEEVDPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELVKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLTLAKGEYKMALKNLEMISDEIHERRRSSAMGPRGCGVGAEGSSTSVEDLPGSKPEPDAISVASEAFEDDSCSNFVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVVRPGSLDLPSPVSLSEFGMMFPVLGPRSECSGASSPECEVERGDRAEGAENKTSDKANNNRGLSSSSGSGGSSKSQSSTSPEGQALENRMKQLSLQCSKGRDGIIADIKMVQIG
uniprot
proteins
function
FUNCTION: Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269|PubMed:10339589, ECO:0000269|PubMed:26506309, ECO:0000269|PubMed:30217979, ECO:0000269|PubMed:9571151}.
uniprot
proteins
mass_dalton
50425
uniprot
proteins
mutagenesis
MUTAGEN 52..54; /note="LNQ->AAA: Loss of guanine nucleotide exchange factor activity."; /evidence="ECO:0000269|PubMed:30217979"; MUTAGEN 250..251; /note="LE->AK: Loss of guanine nucleotide exchange factor activity."; /evidence="ECO:0000269|PubMed:30217979"; MUTAGEN 347; /note="L->A: Loss of phosphorylation and binding by phospho-JNK; when associated with A-349."; /evidence="ECO:0000269|PubMed:12167088"; MUTAGEN 349; /note="L->A: Loss of phosphorylation and binding by phospho-JNK; when associated with A-347."; /evidence="ECO:0000269|PubMed:12167088"; MUTAGEN 434; /note="L->A: No change of phosphorylation or binding by phospho-JNK; when associated with A-436."; /evidence="ECO:0000269|PubMed:12167088"; MUTAGEN 436; /note="L->A: No change of phosphorylation or binding by phospho-JNK; when associated with A-434."; /evidence="ECO:0000269|PubMed:12167088
uniprot
proteins
protein_family
SH3BP5 family
uniprot
proteins
pubmed
10339589
uniprot
proteins
pubmed
12167088
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26506309
uniprot
proteins
pubmed
30217979
uniprot
proteins
pubmed
9571151
uniprot
proteins
sequence_length
455
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:30217979}; Peripheral membrane protein {ECO:0000269|PubMed:30217979}. Mitochondrion {ECO:0000269|PubMed:12167088}. Note=Colocalizes with RAB11A on cytoplasmic vesicle membranes. {ECO:0000269|PubMed:30217979}.
uniprot
proteins