Rap1a
entrez
295347
canonical
uniprot
P62836
canonical
ensembl
ENSRNOG00000032463
resolver
ensembl
ENSRNOG00055019443
resolver
ensembl
ENSRNOG00060027692
resolver
ensembl
ENSRNOG00065032267
resolver
ensp
ENSRNOP00000040409
resolver
ensp
ENSRNOP00055026919
resolver
ensp
ENSRNOP00060040048
resolver
ensp
ENSRNOP00065045723
resolver
enst
ENSRNOT00000047836
resolver
enst
ENSRNOT00055033205
resolver
enst
ENSRNOT00060048125
resolver
enst
ENSRNOT00065055558
resolver
genesymbol
Rap1a
resolver
genesymbol_syn
Krev1
resolver
uniprot
P10113
resolver
uniprot_entry
RAP1A_RAT
resolver
uniprot_sec
P10113
resolver
activity_regulation
ACTIVITY REGULATION: Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSCLLL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3 (By similarity). May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO:0000250|UniProtKB:P62834, ECO:0000269|PubMed:17724123}.
uniprot
proteins
mass_dalton
20987
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11179219
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17724123
uniprot
proteins
pubmed
2642744
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17724123}. Early endosome {ECO:0000269|PubMed:17724123}. Late endosome {ECO:0000269|PubMed:17724123}. Cytoplasm {ECO:0000250}. Cell junction {ECO:0000250}. Note=Localized with RAPGEF2 at cell-cell junctions. Colocalized with RAPGEF2 in the perinuclear region (By similarity). Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. {ECO:0000250}.
uniprot
proteins