Hif3a
entrez
64345
canonical
uniprot
Q9JHS2
canonical
ensembl
ENSRNOG00000017198
resolver
ensp
ENSRNOP00000023490
resolver
ensp
ENSRNOP00000097060
resolver
enst
ENSRNOT00000023490
resolver
enst
ENSRNOT00000099745
resolver
genesymbol
Hif3a
resolver
uniprot
A0A8I6GMD1
resolver
uniprot
F1LRL5
resolver
uniprot_entry
A0A8I6GMD1_RAT
resolver
uniprot_entry
F1LRL5_RAT
resolver
uniprot_entry
HIF3A_RAT
resolver
amino_acid_sequence
MDWDQDRSSTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQVRKEGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPRPSLSKKKSEAATGRHFSLRMKSTLTSRGRALNLKAATWKVLHCSGHMRAYKPPAQTSPAGSPRSEPPLQCLVLICEAIPHPASLEPPLGRGAFLSRHSLDMKFTYCDERIAEVAGYSPDDLIGCSAYEYIHALDSDAVSRSIHTLLSKGQAVTGQYRFLARTGGYLWTQTQATVVSGGRGPQSESIICVHFLISRVEENGVVLSLEQTEQHTRRPPQLGTSSKKGIPGNSLDPPAPRILAFLHPPALSEASLAADPRRFCSPDLRRLMAPILDGPPTAATPSTPQAARRPQSPLPADLPDQLAVGLENAHRLSTARKNKTMETDLDIAQDPDTPDLEMLAPYISMDDDFQLNSSEQLPKVHRRPPRTARRPRARSFHGLSPPIPEATLLPRWGSDPRLNCSSPSKGDPPTAPLTPRTRKRALAQSSEDKGLELLETKPPKRSPRLEPGSVLLPPLSLSFLLQGRQLPGNQPDPRAPLVDSHEPLGLAPSLLSLYQHEETIQSRNHFLPAAGLAQTH
uniprot
proteins
function
FUNCTION: Acts as a transcriptional regulator in adaptive response to low oxygen tension. Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis. May act as a tumor suppressor. {ECO:0000250|UniProtKB:Q0VBL6, ECO:0000250|UniProtKB:Q9Y2N7}.
uniprot
proteins
mass_dalton
72888
uniprot
proteins
post_translational_modification
PTM: In normoxia, hydroxylated on Pro-487 in the oxygen-dependent degradation domain (ODD) by PHD. The hydroxylated proline promotes interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. {ECO:0000250|UniProtKB:Q9Y2N7}.; PTM: Ubiquitinated; ubiquitination occurs in a VHL- and oxygen-dependent pathway and subsequently targeted for proteasomal degradation. {ECO:0000250|UniProtKB:Q9Y2N7}.
uniprot
proteins
pubmed
11237857
uniprot
proteins
pubmed
12824304
uniprot
proteins
sequence_length
662
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11237857}. Cytoplasm {ECO:0000269|PubMed:11237857}. Nucleus speckle {ECO:0000250|UniProtKB:Q0VBL6}. Mitochondrion {ECO:0000250|UniProtKB:Q0VBL6}. Note=In the nuclei of all periportal and perivenous hepatocytes. In the distal perivenous zone, detected in the cytoplasm of the hepatocytes (PubMed:11237857). Localized in the cytoplasm and nuclei under normoxia, but increased in the nucleus under hypoxic conditions. Colocalized with HIF1A in kidney tumors. Colocalizes with BAD in the cytoplasm. Colocalizes with EPAS1 and HIF1A in the nucleus and speckles. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. {ECO:0000250|UniProtKB:Q0VBL6, ECO:0000250|UniProtKB:Q9Y2N7}.
uniprot
proteins