TMPRSS4
entrez
56649
canonical
uniprot
Q9NRS4
canonical
ensembl
ENSG00000137648
resolver
ensp
ENSP00000416037
resolver
ensp
ENSP00000428814
resolver
ensp
ENSP00000429209
resolver
ensp
ENSP00000430547
resolver
ensp
ENSP00000435184
resolver
ensp
ENSP00000519645
resolver
ensp
ENSP00000671396
resolver
ensp
ENSP00000776786
resolver
ensp
ENSP00000776787
resolver
ensp
ENSP00000783423
resolver
enst
ENST00000522307
resolver
enst
ENST00000714378
resolver
genesymbol
TMPRSS4
resolver
genesymbol_syn
TMPRSS3
resolver
hgnc
HGNC:11878
resolver
uniprot
A0AAQ5BHV4
resolver
uniprot
A8MU84
resolver
uniprot
B0YJB0
resolver
uniprot
B7Z458
resolver
uniprot
B7Z8C5
resolver
uniprot
B7Z8X1
resolver
uniprot
B7Z900
resolver
uniprot
E7ERX8
resolver
uniprot
E7ESG9
resolver
uniprot
Q5XKQ6
resolver
uniprot
Q6UX37
resolver
uniprot
Q9NZA5
resolver
uniprot_entry
A0AAQ5BHV4_HUMAN
resolver
uniprot_entry
B7Z458_HUMAN
resolver
uniprot_entry
B7Z8X1_HUMAN
resolver
uniprot_entry
B7Z900_HUMAN
resolver
uniprot_entry
E7ESG9_HUMAN
resolver
uniprot_entry
TMPS4_HUMAN
resolver
uniprot_sec
A8MU84
resolver
uniprot_sec
B0YJB0
resolver
uniprot_sec
B7Z8C5
resolver
uniprot_sec
E7ERX8
resolver
uniprot_sec
Q5XKQ6
resolver
uniprot_sec
Q6UX37
resolver
uniprot_sec
Q9NZA5
resolver
amino_acid_sequence
MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (PubMed:24434139). Seems to be capable of activating ENaC (By similarity). {ECO:0000250|UniProtKB:Q8VCA5, ECO:0000269|PubMed:24434139}.; FUNCTION: (Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry. {ECO:0000269|PubMed:32404436}.
uniprot
proteins
mass_dalton
48246
uniprot
proteins
mutagenesis
MUTAGEN 290; /note="D->A: Abolishes protease activity."; /evidence="ECO:0000269|PubMed:24434139"; MUTAGEN 387; /note="S->A: Abolishes protease activity."; /evidence="ECO:0000269|PubMed:24434139
uniprot
proteins
post_translational_modification
PTM: Proteolytically processed; probably by an autocatalytic mechanism. {ECO:0000305|PubMed:25203520}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10825129
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
24434139
uniprot
proteins
pubmed
25203520
uniprot
proteins
pubmed
32404436
uniprot
proteins
sequence_length
437
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:24434139}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Transmembrane protease serine 4 catalytic chain]: Secreted {ECO:0000269|PubMed:24434139}. Note=Activated by cleavage and secreted. {ECO:0000269|PubMed:24434139}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..53; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins