MICALL1
entrez
85377
canonical
uniprot
Q8N3F8
canonical
ensembl
ENSG00000100139
resolver
ensp
ENSP00000215957
resolver
ensp
ENSP00000404543
resolver
ensp
ENSP00000416766
resolver
ensp
ENSP00000505762
resolver
ensp
ENSP00000589504
resolver
enst
ENST00000215957
resolver
enst
ENST00000424008
resolver
enst
ENST00000445494
resolver
enst
ENST00000680578
resolver
genesymbol
MICALL1
resolver
genesymbol_syn
KIAA1668
resolver
genesymbol_syn
MIRAB13
resolver
hgnc
HGNC:29804
resolver
uniprot
A0A7P0T9P2
resolver
uniprot
B0QY86
resolver
uniprot
B0QY91
resolver
uniprot
Q5TI16
resolver
uniprot
Q7RTP5
resolver
uniprot
Q8N3N8
resolver
uniprot
Q9BVL9
resolver
uniprot
Q9BY92
resolver
uniprot
Q9UH43
resolver
uniprot
Q9UH44
resolver
uniprot
Q9UH45
resolver
uniprot_entry
A0A7P0T9P2_HUMAN
resolver
uniprot_entry
B0QY86_HUMAN
resolver
uniprot_entry
B0QY91_HUMAN
resolver
uniprot_entry
MILK1_HUMAN
resolver
uniprot_sec
Q5TI16
resolver
uniprot_sec
Q7RTP5
resolver
uniprot_sec
Q8N3N8
resolver
uniprot_sec
Q9BVL9
resolver
uniprot_sec
Q9BY92
resolver
uniprot_sec
Q9UH43
resolver
uniprot_sec
Q9UH44
resolver
uniprot_sec
Q9UH45
resolver
amino_acid_sequence
MAGPRGALLAWCRRQCEGYRGVEIRDLSSSFRDGLAFCAILHRHRPDLLDFDSLSKDNVFENNRLAFEVAEKELGIPALLDPNDMVSMSVPDCLSIMTYVSQYYNHFCSPGQAGVSPPRKGLAPCSPPSVAPTPVEPEDVAQGEELSSGSLSEQGTGQTPSSTCAACQQHVHLVQRYLADGRLYHRHCFRCRRCSSTLLPGAYENGPEEGTFVCAEHCARLGPGTRSGTRPGPFSQPKQQHQQQLAEDAKDVPGGGPSSSAPAGAEADGPKASPEARPQIPTKPRVPGKLQELASPPAGRPTPAPRKASESTTPAPPTPRPRSSLQQENLVEQAGSSSLVNGRLHELPVPKPRGTPKPSEGTPAPRKDPPWITLVQAEPKKKPAPLPPSSSPGPPSQDSRQVENGGTEEVAQPSPTASLESKPYNPFEEEEEDKEEEAPAAPSLATSPALGHPESTPKSLHPWYGITPTSSPKTKKRPAPRAPSASPLALHASRLSHSEPPSATPSPALSVESLSSESASQTAGAELLEPPAVPKSSSEPAVHAPGTPGNPVSLSTNSSLASSGELVEPRVEQMPQASPGLAPRTRGSSGPQPAKPCSGATPTPLLLVGDRSPVPSPGSSSPQLQVKSSCKENPFNRKPSPAASPATKKATKGSKPVRPPAPGHGFPLIKRKVQADQYIPEEDIHGEMDTIERRLDALEHRGVLLEEKLRGGLNEGREDDMLVDWFKLIHEKHLLVRRESELIYVFKQQNLEQRQADVEYELRCLLNKPEKDWTEEDRAREKVLMQELVTLIEQRNAIINCLDEDRQREEEEDKMLEAMIKKKEFQREAEPEGKKKGKFKTMKMLKLLGNKRDAKSKSPRDKS
uniprot
proteins
function
FUNCTION: Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}.
uniprot
proteins
mass_dalton
93441
uniprot
proteins
mutagenesis
MUTAGEN 385..387; /note="PLP->ALA: No effect on interaction with PACSIN2. Loss of interaction with PACSIN2; when associated with 480-A--A-483."; /evidence="ECO:0000269|PubMed:23596323"; MUTAGEN 425..427; /note="NPF->APA: Partial loss of interaction with EHD1. Complete loss of interaction with EHD1; when associated with 633-A--A-635."; /evidence="ECO:0000269|PubMed:19864458"; MUTAGEN 428..430; /note="EEE->AAA: Strongly reduces interaction with EHD1."; /evidence="ECO:0000269|PubMed:20106972"; MUTAGEN 480..483; /note="PRAP->ARAA: No effect on interaction with PACSIN2. Loss of interaction with PACSIN2; when associated with 385-A--A-387."; /evidence="ECO:0000269|PubMed:23596323"; MUTAGEN 633..635; /note="NPF->APA: No effect on interaction with EHD1. Complete loss of interaction with EHD1; when associated with 425-A--A-427."; /evidence="ECO:0000269|PubMed:19864458"; MUTAGEN 721..726; /note="MLVDWF->AAAAAA: Altered association with membranes."; /evidence="ECO:0000269|PubMed:19864458"; MUTAGEN 742..743; /note="LI->AA: Loss of binding to phosphatidic acid and association with membrane tubules. No effect on interaction with RAB8A and RAB13."; /evidence="ECO:0000269|PubMed:34100897
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11258795
uniprot
proteins
pubmed
12110185
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19864458
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20106972
uniprot
proteins
pubmed
20801876
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21795389
uniprot
proteins
pubmed
21951725
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23596323
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
31615969
uniprot
proteins
pubmed
34100897
uniprot
proteins
sequence_length
863
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:21951725, ECO:0000269|PubMed:34100897}; Peripheral membrane protein {ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:34100897}. Late endosome membrane. Cell projection, cilium membrane {ECO:0000269|PubMed:31615969}; Peripheral membrane protein {ECO:0000269|PubMed:31615969}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:31615969}. Note=Localization to late endosomes is actin-dependent. Association to tubular recycling endosomes is regulated by RAB35 and ARF6 (PubMed:21951725). Interaction with tubulins achors MICALL1 to the centriole (PubMed:31615969). {ECO:0000269|PubMed:21951725, ECO:0000269|PubMed:31615969}.
uniprot
proteins