Tppp
entrez
361466
canonical
uniprot
D3ZQL7
canonical
ensembl
ENSRNOG00000028261
resolver
ensembl
ENSRNOG00055003273
resolver
ensembl
ENSRNOG00060024965
resolver
ensembl
ENSRNOG00065018290
resolver
ensp
ENSRNOP00000085473
resolver
ensp
ENSRNOP00055003777
resolver
ensp
ENSRNOP00060035784
resolver
ensp
ENSRNOP00065024400
resolver
enst
ENSRNOT00055005081
resolver
enst
ENSRNOT00060043227
resolver
enst
ENSRNOT00065030664
resolver
genesymbol
Tppp
resolver
uniprot
A0A0G2K2D6
resolver
uniprot_entry
TPPP_RAT
resolver
uniprot_sec
A0A0G2K2D6
resolver
amino_acid_sequence
MADSKAKPTKAANKTPPKSPGDPAKAAKRLSLESEGANEGAAAAPELSALEEAFRRFAVHGDTRATGKEMHGKNWSKLCKDCHVIDGKNVTVTDVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGRAPVISGVTKAVSSPTVSRLTDTSKFTGSHKERFDQSGKGKGKAGRVDLVDESGYVPGYKHAGTYDQKVQGGK
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:19606501). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (By similarity). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (By similarity). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (By similarity). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (By similarity). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (By similarity). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (By similarity). Plays a role in cell proliferation by regulating the G1/S-phase transition (By similarity). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (By similarity). {ECO:0000250|UniProtKB:O94811, ECO:0000269|PubMed:19606501}.
uniprot
proteins
mass_dalton
23547
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by LIMK1 on serine residues; phosphorylation may alter the tubulin polymerization activity. Phosphorylation by LIMK2, but not LIMK1, regulates astral microtubule organization at early stage of mitosis. Phosphorylation by ROCK1 at Ser-31, Ser-106 and Ser-158 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin, increased cell motility and entry into S-phase. Phosphorylation by CDK1 inhibits the microtubule polymerizing activity. {ECO:0000250|UniProtKB:O94811}.; PTM: Degraded by the proteasome; zinc-binding inhibits degradation by the proteasome. {ECO:0000250|UniProtKB:O94811}.
uniprot
proteins
protein_family
TPPP family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
19606501
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
31522887
uniprot
proteins
pubmed
8417144
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi outpost {ECO:0000269|PubMed:31522887}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:31522887}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O94811}. Nucleus {ECO:0000250|UniProtKB:O94811}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:O94811}. Note=Specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (PubMed:31522887). Mainly localizes to the cytoskeleton. Also found in the nucleus; however, nuclear localization is unclear and requires additional evidence. Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies. During mitosis, colocalizes with LIMK2 at the mitotic spindle (By similarity). {ECO:0000250|UniProtKB:O94811, ECO:0000269|PubMed:31522887}.
uniprot
proteins