Nipsnap1
entrez
18082
canonical
uniprot
O55125
canonical
ensembl
ENSMUSG00000034285
resolver
ensp
ENSMUSP00000049338
resolver
enst
ENSMUST00000038570
resolver
genesymbol
Nipsnap1
resolver
uniprot
Q5SVF7
resolver
uniprot_entry
NIPS1_MOUSE
resolver
uniprot_entry
Q5SVF7_MOUSE
resolver
amino_acid_sequence
MAPRLCIISAAARRLFTKPRPRAGDLAAAGAVRFYSKDSEGSWFRSLFVHKVDPRKDAHSTLLSKKETSNLYKIQFHNVKPECLDAYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYGEQDQAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRKERSKMLLSRRNQLLLEFSFWNEPQPRAGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDLQSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ
uniprot
proteins
function
FUNCTION: Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria (PubMed:30982665). Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2) (By similarity). {ECO:0000250|UniProtKB:Q9BPW8, ECO:0000269|PubMed:30982665}.
uniprot
proteins
mass_dalton
33363
uniprot
proteins
post_translational_modification
PTM: In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1. {ECO:0000250|UniProtKB:Q9BPW8}.
uniprot
proteins
protein_family
NipSnap family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
30982665
uniprot
proteins
pubmed
9661659
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q9BPW8}.
uniprot
proteins