Q9R0L7
uniprot
Q9R0L7
canonical
amino_acid_sequence
MSYTGFVQGSETTLQSTYCDTSAQPTCDYGYGTWNSGTNRGYENYGYGYGYGQDNTTNYGYGMATSHSWEMASSDTNANPSASGSASADSVLSRINQRLDMMPHLETDMIQGGVYGSGGGERYDSYEACDSRAILSERDLYRSSYDYGELDPEMEMAYEGQYDAYRDQFRMRGGDTFGPRAQGWARDARSGRPMASGYGRMWEDPMGARGQCMPGASRLPSLFSQNIIPEYGMFQGMRGGGAFSGGSRFGFGFGNGMKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEAAEGTESAEAMEKGSRVDGEDEEGKEDGREEGKEDPEKGALTAQDESSQAKRKLQASKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMGSHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIQQIYRDQDLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTDNPEEEKEQDEVEAGALDEGAPSEATELTEGVPAQPPVPLEPAPGTTTPPPPPPPEEEESPVPLLGGALQCQIRGIPGLDMEDDEEGGGGP
uniprot
proteins
function
FUNCTION: Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export. Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis. May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8. May be involved in regulation of pre-mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q9ULX6}.
uniprot
proteins
mass_dalton
71454
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine or threonine residues possibly by PKA. {ECO:0000250|UniProtKB:Q9ULX6}.
uniprot
proteins
protein_family
AKAP95 family
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
642
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9ULX6}. Nucleus matrix {ECO:0000250|UniProtKB:Q9ULX6}. Nucleus speckle {ECO:0000250|UniProtKB:Q9ULX6}. Nucleus, PML body {ECO:0000250|UniProtKB:Q9ULX6}. Cytoplasm {ECO:0000250|UniProtKB:Q9ULX6}. Note=Colocalizes with PRPF40A in the nuclear matrix. Nuclear at steady state but shuttles between the nucleus and cytoplasm. The shuttling property has been questioned. Colocalizes with EBNA-LP in PML bodies. {ECO:0000250|UniProtKB:Q9ULX6}.
uniprot
proteins