Adrb1
entrez
11554
canonical
uniprot
P34971
canonical
ensembl
ENSMUSG00000035283
resolver
ensp
ENSMUSP00000040847
resolver
enst
ENSMUST00000038949
resolver
genesymbol
Adrb1
resolver
genesymbol_syn
Adrb1r
resolver
uniprot
B2RVY4
resolver
uniprot_entry
ADRB1_MOUSE
resolver
uniprot_sec
B2RVY4
resolver
amino_acid_sequence
MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPEPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGTTPPARLLEPWTGCNGGTTTVDSDSSLDEPGRQGFSSESKV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for catecholamines that couples to G(s) proteins to activate adenylate cyclase and cAMP-dependent pathway. Binds epinephrine and norepinephrine with approximately equal affinity. Mediates the activation of Ras via binding with cAMP-dependent RAPGEF2. As part of the sympathetic nervous system, plays a role in the physiologic regulation of cardiac function such as stimulation of cardiomyocyte contraction (By similarity). Also delivers proapoptotic signals in cardiomyocytes (PubMed:11171998). Involved in the regulation of sleep/wake behaviors (PubMed:31473062). {ECO:0000250|UniProtKB:P08588, ECO:0000269|PubMed:11171998, ECO:0000269|PubMed:31473062}.
uniprot
proteins
mass_dalton
50494
uniprot
proteins
mutagenesis
MUTAGEN 187; /note="A->V: In knockin mouse model, decreases protein levels. Mice exhibit a short sleep phenotype. Changes the electrophysiological properties of dorsal pons neurons."; /evidence="ECO:0000269|PubMed:31473062
uniprot
proteins
post_translational_modification
PTM: Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
uniprot
proteins
protein_family
ADRB1 sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11171998
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
31473062
uniprot
proteins
pubmed
8395893
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P18090}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08588}. Note=Colocalizes with RAPGEF2 at the plasma membrane. Localized at the plasma membrane (By similarity). Found in the Golgi upon GOPC overexpression. Localized to early endosomes during endocytic trafficking (By similarity). {ECO:0000250|UniProtKB:P08588, ECO:0000250|UniProtKB:P18090}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..81; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P08588"; TRANSMEM 96..121; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P08588"; TRANSMEM 129..154; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P08588"; TRANSMEM 177..199; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P08588"; TRANSMEM 222..245; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P08588"; TRANSMEM 313..338; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P08588"; TRANSMEM 347..366; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P08588
uniprot
proteins