Ndel1
entrez
83431
canonical
uniprot
Q9ERR1
canonical
ensembl
ENSMUSG00000018736
resolver
ensp
ENSMUSP00000018880
resolver
ensp
ENSMUSP00000298359
resolver
ensp
ENSMUSP00000298376
resolver
genesymbol
Ndel1
resolver
genesymbol_syn
Nudel
resolver
uniprot
Q9D0Q4
resolver
uniprot
Q9EPT6
resolver
uniprot_entry
NDEL1_MOUSE
resolver
uniprot_sec
Q9D0Q4
resolver
uniprot_sec
Q9EPT6
resolver
amino_acid_sequence
MDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENSFPSPKAIPNGFGTSPLTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYVPGSVNCGVMNSNGPECPRSGRATFFHKGAVNGFDPAPPPPGLGSSRPSSAPGMLPLSV
uniprot
proteins
function
FUNCTION: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (By similarity). {ECO:0000250|UniProtKB:Q78PB6, ECO:0000250|UniProtKB:Q9GZM8, ECO:0000269|PubMed:12796778, ECO:0000269|PubMed:15208636, ECO:0000269|PubMed:15473966, ECO:0000269|PubMed:16107726, ECO:0000269|PubMed:16203747, ECO:0000269|PubMed:27777970}.
uniprot
proteins
mass_dalton
38366
uniprot
proteins
mutagenesis
MUTAGEN 198; /note="S->A: Reduces phosphorylation by CDK5 and impairs interaction with YWHAE. Impairs interaction with KATNA1; when associated with A-219 and A-231."; /evidence="ECO:0000269|PubMed:12796778, ECO:0000269|PubMed:16203747"; MUTAGEN 219; /note="T->A: Reduces phosphorylation by CDK5 and impairs interaction with YWHAE. Impairs interaction with KATNA1; when associated with A-198 and A-231."; /evidence="ECO:0000269|PubMed:12796778, ECO:0000269|PubMed:16203747"; MUTAGEN 231; /note="S->A: Reduces phosphorylation by CDK5 and impairs interaction with YWHAE. Impairs interaction with KATNA1; when associated with A-198 and A-219."; /evidence="ECO:0000269|PubMed:12796778, ECO:0000269|PubMed:16203747"; MUTAGEN 266; /note="L->A: Impairs interaction with DISC1."; /evidence="ECO:0000269|PubMed:14962739"; MUTAGEN 267; /note="E->A: Impairs interaction with DISC1."; /evidence="ECO:0000269|PubMed:14962739
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK1 and MAPK1 (By similarity). Phosphorylated in mitosis. Phosphorylated by CDK5. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE. {ECO:0000250, ECO:0000269|PubMed:11163259, ECO:0000269|PubMed:12796778, ECO:0000269|PubMed:16203747}.; PTM: Palmitoylation at Cys-273 reduces affinity for dynein. {ECO:0000250}.
uniprot
proteins
protein_family
NudE family
uniprot
proteins
pubmed
11163259
uniprot
proteins
pubmed
11163260
uniprot
proteins
pubmed
11231056
uniprot
proteins
pubmed
12796778
uniprot
proteins
pubmed
14962739
uniprot
proteins
pubmed
15147871
uniprot
proteins
pubmed
15208636
uniprot
proteins
pubmed
15473966
uniprot
proteins
pubmed
15473967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15797709
uniprot
proteins
pubmed
16107726
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16203747
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27777970
uniprot
proteins
sequence_length
345
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the kinetochore in a CENPF-dependent manner. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Localizes to the interphase centrosome and the mitotic spindle. {ECO:0000250}.
uniprot
proteins