Appbp2
entrez
303396
canonical
uniprot
A5HK05
canonical
ensembl
ENSRNOG00000027654
resolver
ensembl
ENSRNOG00055029115
resolver
ensembl
ENSRNOG00060026426
resolver
ensembl
ENSRNOG00065020621
resolver
ensp
ENSRNOP00000032753
resolver
ensp
ENSRNOP00055041508
resolver
ensp
ENSRNOP00060037963
resolver
ensp
ENSRNOP00065028055
resolver
enst
ENSRNOT00055050423
resolver
enst
ENSRNOT00060045752
resolver
enst
ENSRNOT00065034917
resolver
genesymbol
Appbp2
resolver
uniprot
B5DFE4
resolver
uniprot
Q5BJX9
resolver
uniprot_entry
APBP2_RAT
resolver
uniprot_entry
B5DFE4_RAT
resolver
uniprot_sec
Q5BJX9
resolver
activity_regulation
ACTIVITY REGULATION: E3 ubiquitin-protein ligase activity of the CRL2(APPBP2) complex is inhibited by APP. {ECO:0000250|UniProtKB:Q92624}.
uniprot
proteins
amino_acid_sequence
MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANRAALYGELCALLFAKSHYDEAYKWCVEAMKEITSGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSTGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVNSSPQSTEEVVQSFLMSQNVEGPSC
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation. The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron (By similarity). The CRL2(APPBP2) complex negatively regulates beige adipocyte differentiation by mediating ubiquitination and degradation of PRDM16 (By similarity). May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface (By similarity). {ECO:0000250|UniProtKB:Q92624, ECO:0000250|UniProtKB:Q9DAX9}.
uniprot
proteins
mass_dalton
66902
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q92624}.
uniprot
proteins
post_translational_modification
PTM: Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP. {ECO:0000250|UniProtKB:Q92624}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92624}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q92624}. Membrane {ECO:0000250|UniProtKB:Q92624}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q92624}. Note=Associated with membranes and microtubules. {ECO:0000250|UniProtKB:Q92624}.
uniprot
proteins