Armc5
entrez
233912
canonical
uniprot
Q5EBP3
canonical
ensembl
ENSMUSG00000042178
resolver
ensp
ENSMUSP00000040568
resolver
ensp
ENSMUSP00000321674
resolver
enst
ENSMUST00000044660
resolver
genesymbol
Armc5
resolver
uniprot
Q6KAU6
resolver
uniprot
Q8CDI5
resolver
uniprot
Q8R3J0
resolver
uniprot_entry
ARMC5_MOUSE
resolver
uniprot_sec
Q6KAU6
resolver
uniprot_sec
Q8CDI5
resolver
uniprot_sec
Q8R3J0
resolver
amino_acid_sequence
MAAARPALTDSLSFCLAQLTAAAGEGPGGGKDPATNETPLGRALLALRTRHIKAAEGIERFRARGGLRPLLALLRRTAAAGPAPSQAASGSAPSSVASAGSTPGHAPAAESLLTPSLPMRLRKTLDLALSILANCCTEGACRAEVRRLGGILPLVTILQCVKTDSIQNRTARALGNLAMEPESCRDIHSAGAVPFLVESLTACQDSQCLQSIVRALRNLADSPQHRLALAQQGAVRPLAELLATAPDPALTAALVRALLELSRGCSRACAEQLSLGGALGPLVSLASHPKRAIREAAILILANLCAQGLVRPALGNAGGVEVLLGELRRRRSPGGSSSATQQPLVRAVCLLCREAINRARLRDAGGLELLMGLLQDPGASAWHPRVVAALVGFLYDTGALGKLQALGLVPLLARQLCGEAGEEEEEGIEAASWDFPEERTSGQAEGGSFRSLRLWLISEGYAAGPGDISPDWSPERCPMPEPSESVSPTPGQTSMSTPRTLRKPGRIPAATPEEPWGQEGPALLLLSRFSQAPDPSGALVTGPALCGLLAYVTGAPGPPNPRALRILARLTCNPACLEAFVRTYGAALLRAWLVLGVSPDDWPVPHARPVHRSQHRELGEMLLQNLTVQAESPFGVGALTHLLLSGSPEDRVACALTLPFICRKPTLWRRLLLDQGGLRLLLTALTQPAPHPLFLFFAADSLSCLQGLVSPTASPVPLPALPLELDSPPPCLYEPLLGPAPAPAPDLHFVLDSGLQLPAQRAASAAASPFFRALLSGSFAEAQMDLVPLRGLSPGAAWPVLHHLHGCRGCGAALGPVPPPGQPLLGSKAEEALEAAGRFLLPALEEELEEAVGRIHLSPRGGPESVGEVFRLGRPRLAAHCARWTLEPGQCPRKRALALTGLVEAAGEEAGPLTEALLAVVMGIES
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (By similarity). The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation (By similarity). The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II (By similarity). The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2 (PubMed:39491648). Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:28169274). Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (By similarity). {ECO:0000250|UniProtKB:Q96C12, ECO:0000269|PubMed:28169274, ECO:0000269|PubMed:39491648}.
uniprot
proteins
mass_dalton
96728
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q96C12}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex, leading to its degradation. Deubiquitinated by USP7. {ECO:0000250|UniProtKB:Q96C12}.
uniprot
proteins
pubmed
15449545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
28169274
uniprot
proteins
pubmed
35687106
uniprot
proteins
pubmed
38225631
uniprot
proteins
pubmed
39491648
uniprot
proteins
sequence_length
926
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96C12}. Chromosome {ECO:0000250|UniProtKB:Q96C12}. Cytoplasm {ECO:0000269|PubMed:28169274}. Note=Associates to RNA polymerase II (Pol II) on chromatin. {ECO:0000250|UniProtKB:Q96C12}.
uniprot
proteins