Kcnh6
entrez
116745
canonical
uniprot
O54853
canonical
ensembl
ENSRNOG00000008078
resolver
ensembl
ENSRNOG00055029484
resolver
ensembl
ENSRNOG00060013787
resolver
ensp
ENSRNOP00000010816
resolver
ensp
ENSRNOP00055042089
resolver
ensp
ENSRNOP00060018710
resolver
enst
ENSRNOT00000010816
resolver
enst
ENSRNOT00055051091
resolver
enst
ENSRNOT00060023554
resolver
genesymbol
Kcnh6
resolver
genesymbol_syn
Erg2
resolver
uniprot
G3V720
resolver
uniprot_entry
G3V720_RAT
resolver
uniprot_entry
KCNH6_RAT
resolver
amino_acid_sequence
MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQRPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKSSSRSLTQRLLSHSFLGSEGSHSRPSGQGPGPGRGKYRTVSQIPQFTLNFVEFNLEKHRSGSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRGTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESQRGTCGYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEPKIGWLDSLGAQLGKQYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFRGASKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPASLHARPGKSSADVRALTYCDLHKIHRADLLEVLDMYPAFADTFWNKLEVTFNLRDADGGLQSTPRQAPGHQDPQGFFLNDSQSGAAPSLSISDTSALWPELLQQMPPSPPNPRQDLDCWHRELGFKLEQLQAQMNRLESRVSSDLSRILQLLQHPQGRPSYILGASASSDLASFPETSVTRSSESTLLVGHVPSAQTLSYGDLDDHIQTPRNFSPRTPHVAMAMDKTLVPSSEQEQPGGLLSPLASPLRPLEVPGLGGSRFPSLPEHLSSVPKQLEFQRHGSDPGFTRS
uniprot
proteins
function
FUNCTION: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed:11212207, PubMed:9390998). Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization (PubMed:11212207, PubMed:9390998). Activates even more slowly than KCNH2 (PubMed:9390998). {ECO:0000269|PubMed:11212207, ECO:0000269|PubMed:9390998}.
uniprot
proteins
mass_dalton
105706
uniprot
proteins
mutagenesis
MUTAGEN 480; /note="G->S: Dominant negative mutant; abolishes ERG current."; /evidence="ECO:0000269|PubMed:11212207
uniprot
proteins
protein_family
H (Eag) (TC 1.A.1.20) subfamily
uniprot
proteins
protein_family
Kv11.2/KCNH6 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10718922
uniprot
proteins
pubmed
11212207
uniprot
proteins
pubmed
11425889
uniprot
proteins
pubmed
9390998
uniprot
proteins
sequence_length
950
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q12809}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12809}.
uniprot
proteins
transmembrane_region
TRANSMEM 262..282; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 299..319; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 341..361; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 371..391; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 399..419; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 491..511; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins