Klhl21
entrez
313743
canonical
uniprot
D4A2K4
canonical
ensembl
ENSRNOG00000003334
resolver
ensembl
ENSRNOG00055015527
resolver
ensembl
ENSRNOG00060003558
resolver
ensembl
ENSRNOG00065009694
resolver
ensp
ENSRNOP00000004508
resolver
ensp
ENSRNOP00055021501
resolver
ensp
ENSRNOP00060004249
resolver
ensp
ENSRNOP00065011742
resolver
enst
ENSRNOT00000004508
resolver
enst
ENSRNOT00055026480
resolver
enst
ENSRNOT00060005826
resolver
enst
ENSRNOT00065015569
resolver
genesymbol
Klhl21
resolver
uniprot_entry
KLH21_RAT
resolver
amino_acid_sequence
MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPMLKAREYHSSSVLNGLLYVVAADSTERYDHATDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVIQCYDPDTDLWSMVNCGQLPPWSFAPKTVTLNGLMYFVRDDSAEVDVYNPTKDEWDKIPSMNQVHVGGSLAALGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQTPAGGRGFELNSGSSDVDAGHHRLPQNPEELQ
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
66448
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
sequence_length
597
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to the spindle midzone and targets CUL3 to this region. {ECO:0000250}.
uniprot
proteins