Ctps2
entrez
619580
canonical
uniprot
Q5U2N0
canonical
ensembl
ENSRNOG00000004257
resolver
ensp
ENSRNOP00000055810
resolver
genesymbol
Ctps2
resolver
uniprot
Q5U3X4
resolver
uniprot_entry
PYRG2_RAT
resolver
uniprot_sec
Q5U3X4
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by CTP. {ECO:0000250|UniProtKB:Q9NRF8}.
uniprot
proteins
amino_acid_sequence
MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYINIDAGTFSPYEHGEVFVLNDGGEVDLDLGNYERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDAIQDWVMNQAKVSVDGNKEDPQICVIELGGTIGDIEGMAFVEAFRQFQFKAKRENFYNIHVSLVPQPSATGEQKTKPTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSIYRVPLLLEEQGVVKYFQERLDLPINDCSNNLLFKWKTMADRYERLQKICSIALVGKYTKLRDCYASVFKALEHSALAINHKLNLMYIDSIDLEPVTKAEDPVKFHEAWQKLCLADGILVPGGFGIRGTLGKLQAISWARTKKIPFLGICLGMQLAVIEFARNCLNLKDANSTEFDPNTPVPLVIDMPEHNPGDLGGTMRLGLRRTVFTTENSILKKLYGDVPYIEERHRHRYEVNPNLINQFENKDLCFVGEDVDGKRMEIIELTGHPYFIGVQFHPEFSSRPMKPSPPYLGLLLAATGTLNTHLQQMSKLSYSDIYSDASDDSFSEAKFAELDIN
uniprot
proteins
ec_number
6.3.4.2
uniprot
proteins
function
FUNCTION: CTP synthase involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. {ECO:0000250|UniProtKB:Q9NRF8}.
uniprot
proteins
mass_dalton
65674
uniprot
proteins
pathway_participation
PATHWAY: Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. {ECO:0000250|UniProtKB:Q9NRF8}.
uniprot
proteins
protein_family
CTP synthase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
586
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9NRF8}. Nucleus {ECO:0000250|UniProtKB:Q9NRF8}. Note=Cytoplasmic and nuclear; detected in long filamentous structures named cytoophidium. {ECO:0000250|UniProtKB:Q9NRF8}.
uniprot
proteins