GPR34
entrez
2857
canonical
uniprot
Q9UPC5
canonical
ensembl
ENSG00000171659
resolver
ensp
ENSP00000367378
resolver
ensp
ENSP00000367384
resolver
ensp
ENSP00000498130
resolver
ensp
ENSP00000554248
resolver
ensp
ENSP00000626459
resolver
ensp
ENSP00000626460
resolver
enst
ENST00000378138
resolver
enst
ENST00000378142
resolver
enst
ENST00000649219
resolver
enst
ENST00000884189
resolver
enst
ENST00000956400
resolver
enst
ENST00000956401
resolver
genesymbol
GPR34
resolver
hgnc
HGNC:4490
resolver
uniprot
O95853
resolver
uniprot
Q5VT14
resolver
uniprot_entry
GPR34_HUMAN
resolver
uniprot_entry
Q5VT14_HUMAN
resolver
uniprot_sec
O95853
resolver
amino_acid_sequence
MRSHTITMTTTSVSSWPYSSHRMRFITNHSDQPPQNFSATPNVTTCPMDEKLLSTVLTTSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIADLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQQRKAITTKQSIYVCCIVWMLALGGFLTMIILTLKKGGHNSTMCFHYRDKHNAKGEAIFNFILVVMFWLIFLLIILSYIKIGKNLLRISKRRSKFPNSGKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNVSSCYWKEIVHKTNEIMLVLSSFNSCLDPVMYFLMSSNIRKIMCQLLFRRFQGEPSRSESTSEFKPGYSLHDTSVAVKIQSSSKST
uniprot
proteins
function
FUNCTION: G protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed:16460680). Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils (By similarity). Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production (By similarity). Plays an important role in microglial function, controlling morphology and phagocytosis (By similarity). {ECO:0000250|UniProtKB:Q9R1K6, ECO:0000269|PubMed:16460680}.
uniprot
proteins
mass_dalton
43860
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10036181
uniprot
proteins
pubmed
10395919
uniprot
proteins
pubmed
10982042
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16460680
uniprot
proteins
pubmed
27086875
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27086875}; Multi-pass membrane protein {ECO:0000269|PubMed:27086875}.
uniprot
proteins
transmembrane_region
TRANSMEM 62..82; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:27086875"; TRANSMEM 89..109; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:27086875"; TRANSMEM 129..149; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:27086875"; TRANSMEM 172..192; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:27086875"; TRANSMEM 217..237; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:27086875"; TRANSMEM 270..290; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:27086875"; TRANSMEM 311..331; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:27086875
uniprot
proteins