Myo1c
entrez
17913
canonical
uniprot
Q9WTI7
canonical
ensembl
ENSMUSG00000017774
resolver
ensp
ENSMUSP00000070388
resolver
ensp
ENSMUSP00000099562
resolver
ensp
ENSMUSP00000099563
resolver
ensp
ENSMUSP00000104069
resolver
genesymbol
Myo1c
resolver
uniprot
O08571
resolver
uniprot
O08834
resolver
uniprot
Q3TBQ4
resolver
uniprot
Q3U231
resolver
uniprot
Q5ND46
resolver
uniprot
Q5ND48
resolver
uniprot
Q5ND49
resolver
uniprot
Q9ERB6
resolver
uniprot
Q9QW54
resolver
uniprot_entry
MYO1C_MOUSE
resolver
uniprot_sec
O08571
resolver
uniprot_sec
O08834
resolver
uniprot_sec
Q3TBQ4
resolver
uniprot_sec
Q3U231
resolver
uniprot_sec
Q5ND46
resolver
uniprot_sec
Q5ND48
resolver
uniprot_sec
Q5ND49
resolver
uniprot_sec
Q9ERB6
resolver
uniprot_sec
Q9QW54
resolver
amino_acid_sequence
MALQVELIPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHVFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVMRKALSVIDFTEDEVEDLLSIVASVLHLGNIHFAADEDSNAQVTTENQLKYLTRLLGVEGTTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVRKINRSLASKDAESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKPHPHFLTHKLADQKTRKSLDRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSMNPIMAQCFDKSELSDKKRPETVATQFKMSLLQLVEILRSKEPAYIRCIKPNDAKQPGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPMWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDSLEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFILRHSPRCPENAFFLDHVRASFLLNLRRQLPRNVLDTSWPTPPPALREASELLRELCMKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTEEISPRVLQSLGSEPIQYAVPVVKYDRKGYKPRPRQLLLTPSAVVIVEDAKVKQRIDYANLTGISVSSLSDSLFVLHVQREDNKQKGDVVLQSDHVIETLTKTALSADRVNNININQGSITFAGGPGRDGIIDFTSGSELLITKAKNGHLAVVAPRLNSR
uniprot
proteins
function
FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which then are moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. {ECO:0000269|PubMed:16971510}.; FUNCTION: [Isoform 3]: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. {ECO:0000269|PubMed:16514417}.
uniprot
proteins
mass_dalton
121944
uniprot
proteins
mutagenesis
MUTAGEN 927; /note="K->A: Inhibits binding to PIP2 and disrupts membrane binding."; /evidence="ECO:0000269|PubMed:16971510"; MUTAGEN 938; /note="R->A: Inhibits binding to PIP2 and disrupts membrane binding."; /evidence="ECO:0000269|PubMed:16971510
uniprot
proteins
post_translational_modification
PTM: Isoform 2 contains a N-acetylmethionine at position 1. {ECO:0000250}.
uniprot
proteins
protein_family
Myosin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
11030652
uniprot
proteins
pubmed
11853671
uniprot
proteins
pubmed
12490950
uniprot
proteins
pubmed
14980509
uniprot
proteins
pubmed
15014434
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15976448
uniprot
proteins
pubmed
16102537
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16492791
uniprot
proteins
pubmed
16514417
uniprot
proteins
pubmed
16957816
uniprot
proteins
pubmed
16960872
uniprot
proteins
pubmed
16971510
uniprot
proteins
pubmed
17994197
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22918957
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
26961175
uniprot
proteins
pubmed
8449986
uniprot
proteins
pubmed
9119401
uniprot
proteins
pubmed
9182797
uniprot
proteins
sequence_length
1063
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11030652, ECO:0000269|PubMed:12490950, ECO:0000269|PubMed:16492791}. Nucleus {ECO:0000250|UniProtKB:O00159}. Cytoplasm, cell cortex {ECO:0000269|PubMed:12490950, ECO:0000269|PubMed:16492791, ECO:0000269|PubMed:17994197}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q92002}. Cytoplasmic vesicle {ECO:0000269|PubMed:22918957}. Cell projection, ruffle membrane {ECO:0000269|PubMed:17994197, ECO:0000269|PubMed:22918957}. Note=Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane (PubMed:17994197). Colocalizes in adipocytes with GLUT4 at actin-based membranes (PubMed:12490950). Colocalizes with GLUT4 at insulin-induced ruffles at the cell membrane (PubMed:22918957). Localizes transiently at cell membrane to region known to be enriched in PIP2 (PubMed:16492791). Activation of phospholipase C results in its redistribution to the cytoplasm (PubMed:16492791). Colocalizes with RNA polymerase II (By similarity). Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription (By similarity). {ECO:0000250|UniProtKB:O00159, ECO:0000269|PubMed:12490950, ECO:0000269|PubMed:16492791, ECO:0000269|PubMed:17994197, ECO:0000269|PubMed:22918957}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleolus {ECO:0000269|PubMed:11030652, ECO:0000269|PubMed:16514417, ECO:0000305|PubMed:16957816}. Nucleus, nucleoplasm {ECO:0000269|PubMed:16514417}. Note=Colocalizes with RNA polymerase II in the nucleus (PubMed:11030652). Colocalizes with RNA polymerase I in nucleoli (PubMed:16514417). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC) (By similarity). Accumulates strongly in DFC and GC during activation of transcription (By similarity). Colocalizes with transcription sites (PubMed:16514417). Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6 (By similarity). Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles (By similarity). Colocalizes with RPS6 at the nuclear pore level (By similarity). {ECO:0000250|UniProtKB:O00159, ECO:0000269|PubMed:11030652, ECO:0000269|PubMed:16514417}.
uniprot
proteins