Psma8
entrez
73677
canonical
uniprot
Q9CWH6
canonical
ensembl
ENSMUSG00000036743
resolver
ensp
ENSMUSP00000042590
resolver
ensp
ENSMUSP00000157022
resolver
ensp
ENSMUSP00000345256
resolver
enst
ENSMUST00000040860
resolver
enst
ENSMUST00000234680
resolver
genesymbol
Psma8
resolver
genesymbol_syn
Psma7l
resolver
uniprot
A0A3Q4EGK8
resolver
uniprot
B7ZMS3
resolver
uniprot
B7ZMS4
resolver
uniprot
Q14A44
resolver
uniprot_entry
A0A3Q4EGK8_MOUSE
resolver
uniprot_entry
B7ZMS3_MOUSE
resolver
uniprot_entry
B7ZMS4_MOUSE
resolver
uniprot_entry
PSMA8_MOUSE
resolver
uniprot_sec
Q14A44
resolver
amino_acid_sequence
MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKICALDDHVCMAFAGLTADARVVISRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGIPRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAISNDKEAIKLAIKALLEVVQSGGKNIELAIIRRDQPLKMFSAKEIELEVSEIEREKDEAEKTKSKKST
uniprot
proteins
function
FUNCTION: Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis (PubMed:23706739, PubMed:31358751, PubMed:31437213). The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds (Probable). Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis (PubMed:31358751). Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I (PubMed:31437213). {ECO:0000269|PubMed:23706739, ECO:0000269|PubMed:31358751, ECO:0000269|PubMed:31437213, ECO:0000305}.
uniprot
proteins
mass_dalton
27866
uniprot
proteins
protein_family
Peptidase T1A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23706739
uniprot
proteins
pubmed
31358751
uniprot
proteins
pubmed
31437213
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31437213}. Note=Localizes to the central region of the synaptonemal complex. {ECO:0000269|PubMed:31437213}.
uniprot
proteins