PHF7
entrez
51533
canonical
uniprot
Q9BWX1
canonical
ensembl
ENSG00000010318
resolver
ensp
ENSP00000246282
resolver
ensp
ENSP00000333024
resolver
ensp
ENSP00000417712
resolver
ensp
ENSP00000564792
resolver
ensp
ENSP00000629039
resolver
genesymbol
PHF7
resolver
hgnc
HGNC:18458
resolver
uniprot
A0A024R336
resolver
uniprot
A0A140VK34
resolver
uniprot
A8K856
resolver
uniprot
K4DI82
resolver
uniprot_entry
A0A024R336_HUMAN
resolver
uniprot_entry
A8K856_HUMAN
resolver
uniprot_entry
PHF7_HUMAN
resolver
uniprot_sec
A0A140VK34
resolver
uniprot_sec
K4DI82
resolver
amino_acid_sequence
MKTVKEKKECQRLRKSAKTRRVTQRKPSSGPVCWLCLREPGDPEKLGEFLQKDNISVHYFCLILSSKLPQRGQSNRGFHGFLPEDIKKEAARASRKICFVCKKKGAAINCQKDQCLRNFHLPCGQERGCLSQFFGEYKSFCDKHRPTQNIQHGHVGEESCILCCEDLSQQSVENIQSPCCSQAIYHRKCIQKYAHTSAKHFFKCPQCNNRKEFPQEMLRMGIHIPDRDAAWELEPGAFSDLYQRYQHCDAPICLYEQGRDSFEDEGRWCLILCATCGSHGTHRDCSSLRSNSKKWECEECSPAAATDYIPENSGDIPCCSSTFHPEEHFCRDNTLEENPGLSWTDWPEPSLLEKPESSRGRRSYSWRSKGVRITNSCKKSK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which ubiquitinates histone H3 at 'Lys-14' (By similarity). Required for male fertility, via inhibition of SPOP-mediated BRDT degradation when in the presence of acetylated histone H4 in early condensing spermatids (By similarity). Stabilization of BRDT allows it to facilitate histone removal in early condensing spermatids and promote the progression of histone-to-protamine exchange (By similarity). Promotes the expression of steroidogenesis proteins in the testes, and as a result plays a role in maintaining testosterone levels and repressing osteoclastogenesis (By similarity). Promotes transcription of cardiac enhancer genes by facilitating binding of cardiac transcription factors such as MEF2C and GATA4 to target gene promoters (By similarity). Ubiquitinates histone H4 (PubMed:32726616). Ubiquitinates histone H2A and H3 as part of the nucleosome core particle (By similarity). {ECO:0000250|UniProtKB:Q9DAG9, ECO:0000269|PubMed:32726616}.
uniprot
proteins
mass_dalton
43767
uniprot
proteins
mutagenesis
MUTAGEN 119; /note="F->S: Reduces ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:32726616"; MUTAGEN 126; /note="E->Q: No effect on ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:32726616"; MUTAGEN 133; /note="F->S: Reduces ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:32726616"; MUTAGEN 140; /note="F->S: No effect on ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:32726616"; MUTAGEN 140; /note="Missing: Reduces ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:32726616"; MUTAGEN 160; /note="C->A: Abolishes ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:32726616"; MUTAGEN 186; /note="H->A: Abolishes ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:32726616
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9DAG9}.
uniprot
proteins
pubmed
11829468
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
32726616
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11829468}.
uniprot
proteins