Nrxn1
entrez
60391
canonical
uniprot
Q63372
canonical
ensembl
ENSRNOG00000050220
resolver
ensp
ENSRNOP00000080874
resolver
ensp
ENSRNOP00000084025
resolver
ensp
ENSRNOP00000093237
resolver
ensp
ENSRNOP00000100919
resolver
ensp
ENSRNOP00000111244
resolver
enst
ENSRNOT00000092255
resolver
enst
ENSRNOT00000140337
resolver
enst
ENSRNOT00000166638
resolver
genesymbol
Nrxn1
resolver
uniprot
A0A8I5ZTY7
resolver
uniprot
A0ABK0L7H7
resolver
uniprot
A0ABK0M2R7
resolver
uniprot_entry
A0A8I5ZTY7_RAT
resolver
uniprot_entry
A0ABK0L7H7_RAT
resolver
uniprot_entry
A0ABK0M2R7_RAT
resolver
uniprot_entry
NRX1A_RAT
resolver
amino_acid_sequence
MGTALVQHGGCCLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQALPVDGSEVKLDEEPPNSGGGSPCEAGDEGDGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKEDNNVEGLAHLMMGDQGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEIQSTAGVKPSCSRETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITHKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSANKNKKNKDKEYYV
uniprot
proteins
function
FUNCTION: Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission (By similarity). Function is isoform-specific (By similarity). Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission (By similarity). Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions (By similarity). They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland (By similarity). They may affect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery (By similarity). Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels (By similarity). Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2 (By similarity). In vitro, triggers the de novo formation of presynaptic structures (PubMed:20064387, PubMed:20064388). May be involved in specification of excitatory synapses (PubMed:20064387, PubMed:20064388). Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (PubMed:20064387, PubMed:20064388). {ECO:0000250|UniProtKB:Q9CS84, ECO:0000269|PubMed:20064387, ECO:0000269|PubMed:20064388}.
uniprot
proteins
mass_dalton
167923
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins and LRRTM2. {ECO:0000250|UniProtKB:Q9CS84}.
uniprot
proteins
protein_family
Neurexin family
uniprot
proteins
pubmed
10197529
uniprot
proteins
pubmed
11470830
uniprot
proteins
pubmed
12040031
uniprot
proteins
pubmed
1621094
uniprot
proteins
pubmed
18093522
uniprot
proteins
pubmed
20064387
uniprot
proteins
pubmed
20064388
uniprot
proteins
pubmed
25385611
uniprot
proteins
pubmed
7695896
uniprot
proteins
pubmed
8786425
uniprot
proteins
pubmed
9856994
uniprot
proteins
sequence_length
1530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9CS84}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 1455..1475; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins