SLC8A2
entrez
6543
canonical
uniprot
Q9UPR5
canonical
ensembl
ENSG00000118160
resolver
ensp
ENSP00000236877
resolver
enst
ENST00000236877
resolver
genesymbol
SLC8A2
resolver
genesymbol_syn
KIAA1087
resolver
genesymbol_syn
NCX2
resolver
hgnc
HGNC:11069
resolver
uniprot
B4DYQ9
resolver
uniprot_entry
NAC2_HUMAN
resolver
uniprot_sec
B4DYQ9
resolver
activity_regulation
ACTIVITY REGULATION: Calcium transport is down-regulated by Na(+) and stimulated by Ca(2+). {ECO:0000250|UniProtKB:P48768}.
uniprot
proteins
amino_acid_sequence
MAPLALVGVTLLLAAPPCSGAATPTPSLPPPPANDSDTSTGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLGPGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDEDDGASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIRGF
uniprot
proteins
function
FUNCTION: Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion. {ECO:0000250|UniProtKB:Q8K596}.
uniprot
proteins
mass_dalton
100368
uniprot
proteins
protein_family
Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family
uniprot
proteins
protein_family
SLC8 subfamily
uniprot
proteins
pubmed
10470851
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
23506867
uniprot
proteins
pubmed
24501278
uniprot
proteins
sequence_length
921
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P48768}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48768}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8K596}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K596}. Perikaryon {ECO:0000250|UniProtKB:P48768}. Cell projection, dendrite {ECO:0000250|UniProtKB:P48768}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P48768}.
uniprot
proteins
transmembrane_region
TRANSMEM 69..90; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 131..152; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 197..219; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 223..246; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 721..740; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 748..770; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 773..791; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 823..843; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 855..875; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 893..909; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins