Ddb2
entrez
107986
canonical
uniprot
Q99J79
canonical
ensembl
ENSMUSG00000002109
resolver
ensp
ENSMUSP00000028696
resolver
ensp
ENSMUSP00000171501
resolver
ensp
ENSMUSP00000171516
resolver
enst
ENSMUST00000028696
resolver
genesymbol
Ddb2
resolver
uniprot
Q4FZK4
resolver
uniprot_entry
DDB2_MOUSE
resolver
uniprot_entry
Q4FZK4_MOUSE
resolver
amino_acid_sequence
MAPKKCPETQKSPDVAVLLRSKSRRGPQELEPEAKKLRVQGPVSSRTCESCCLLAELSSLQIPSRSSSIVRDLYQHKLGKATWSSLQQGLQKSFLHSLASYQVFRKAAPFDRRTTSLAWHPTHPSTLAVGSKGGDIMIWNFGIKDKPIFLKGIGAGGSITGLKFNHLNTNQFFASSMEGTTRLQDFKGNILRVYTSSNSCKVWFCSLDVSAKSRVVVTGDNMGHVILLSTDGKELWNLRMHKKKVAHVALNPCCDWLLATASIDQTVKIWDLRQIKGKDSFLYSLPHRHPVNAACFSPDGARLLTTDQNNEIRVYSASQWDSPLNLISHPHRHFQHLTPIKATWHSRHNLIVVGRYPDPNLKSCVPYELRTIDVFDGSSGKMMCQLYDPGYSGITSLNEFNPMGDTLASTMGYHILIWSQEEDGSQKDHERL
uniprot
proteins
function
FUNCTION: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:12107171). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:33937266). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (By similarity). Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1) (By similarity). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (By similarity). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (By similarity). The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (By similarity). The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR (By similarity). {ECO:0000250|UniProtKB:Q92466, ECO:0000269|PubMed:12107171, ECO:0000269|PubMed:33937266}.
uniprot
proteins
mass_dalton
48375
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by ABL1 negatively regulate UV-DDB activity. {ECO:0000269|PubMed:12107171}.; PTM: Ubiquitinated by CUL4A in response to UV irradiation. Ubiquitination appears to both impair DNA-binding and promotes ubiquitin-dependent proteolysis. Degradation of DDB2 at sites of DNA damage may be a prerequisite for their recognition by XPC and subsequent repair. CUL4A-mediated degradation appears to be promoted by ABL1. {ECO:0000250|UniProtKB:Q92466}.; PTM: Ubiquitinated, leading to proteasomal degradation, and deubiquitinated by USP24 (By similarity). Deubiquitinated by USP44; leading to its stabilization on DNA lesions (PubMed:33937266). {ECO:0000250|UniProtKB:Q92466, ECO:0000269|PubMed:33937266}.; PTM: Acetylated. Deacetylation by SIRT6 in response to UV stress facilitates nucleotide excision repair pathway (the NER pathway) transduction. {ECO:0000250|UniProtKB:Q92466}.
uniprot
proteins
protein_family
WD repeat DDB2/WDR76 family
uniprot
proteins
pubmed
10713455
uniprot
proteins
pubmed
12107171
uniprot
proteins
pubmed
14769931
uniprot
proteins
pubmed
15558025
uniprot
proteins
pubmed
17468495
uniprot
proteins
pubmed
17635991
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33937266
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17635991}. Chromosome {ECO:0000250|UniProtKB:Q92466}. Note=Accumulates at sites of DNA damage following UV irradiation. {ECO:0000250|UniProtKB:Q92466}.
uniprot
proteins