Trim32
entrez
69807
canonical
uniprot
Q8CH72
canonical
ensembl
ENSMUSG00000051675
resolver
ensp
ENSMUSP00000062277
resolver
ensp
ENSMUSP00000102989
resolver
ensp
ENSMUSP00000304830
resolver
ensp
ENSMUSP00000304831
resolver
ensp
ENSMUSP00000304834
resolver
ensp
ENSMUSP00000304839
resolver
ensp
ENSMUSP00000304841
resolver
enst
ENSMUST00000050850
resolver
enst
ENSMUST00000107366
resolver
genesymbol
Trim32
resolver
uniprot
Q3TLR3
resolver
uniprot
Q8K055
resolver
uniprot_entry
Q3TLR3_MOUSE
resolver
uniprot_entry
TRI32_MOUSE
resolver
uniprot_sec
Q8K055
resolver
amino_acid_sequence
MAAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVRCPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRGCGRRLPRQFCRSCGVVLCEPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELTGELQRRKAALEGVSRDLQARYKAVLQEYGHEERRIQEELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCDYFLAKIKQADVALLEETADEEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRTVNMEDSWAGEEGAASSASASVTFREMDMSPEEVAPSPRASPAKQRSSEAASGIQQCLFLKKMGAKGSTPGMFNLPVSLYVTSQSEVLVADRGNYRIQVFNRKGFLKEIRRSPSGIDSFVLSFLGADLPNLTPLSVAMNCHGLIGVTDSYDNSLKVYTMDGHCVACHRSQLSKPWGITALPSGQFVVTDVEGGKLWCFTVDRGAGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNVENRQNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEILHFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCVKIYSYHLRRYSTP
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays a role in various biological processes including neural stem cell differentiation, innate immunity, inflammatory resonse and autophagy (PubMed:14578165, PubMed:37415157). Plays a role in virus-triggered induction of IFN-beta and TNF by mediating the ubiquitination of STING1. Mechanistically, targets STING1 for 'Lys-63'-linked ubiquitination which promotes the interaction of STING1 with TBK1. Regulates bacterial clearance and promotes autophagy in Mycobacterium tuberculosis-infected macrophages (By similarity). Negatively regulates TLR3/4-mediated innate immune and inflammatory response by triggering the autophagic degradation of TICAM1 in an E3 activity-independent manner (PubMed:28898289). Plays an essential role in oxidative stress induced cell death by inducing loss of transmembrane potential and enhancing mitochondrial reactive oxygen species (ROS) production during oxidative stress conditions. Ubiquitinates XIAP and targets it for proteasomal degradation. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2 (By similarity). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF (By similarity). Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation. Positively regulates dendritic branching by promoting ubiquitination and subsequent degradation of the epigenetic factor CDYL (By similarity). Under metabolic stress and phosphorylation by CHK2, mediates 'Lys-63'-linked ubiquitination of ATG7 at 'Lys-41' to initiate autophagy (By similarity). {ECO:0000250|UniProtKB:Q13049, ECO:0000269|PubMed:14578165, ECO:0000269|PubMed:16816390, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:37415157}.
uniprot
proteins
mass_dalton
72057
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q13049}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. {ECO:0000269|PubMed:14578165}.; PTM: Phosphorylation at Ser-56 by CHEK2 under oxidative stress, activates the E3 ligase activity and promotes ATG7 ubiquitination leading to positive regulation of the autophagosme assembly. {ECO:0000250|UniProtKB:Q13049}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
14578165
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16816390
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28898289
uniprot
proteins
pubmed
37415157
uniprot
proteins
sequence_length
655
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14578165, ECO:0000269|PubMed:16816390}. Note=Localized in cytoplasmic bodies, often located around the nucleus. {ECO:0000250|UniProtKB:Q13049}.
uniprot
proteins