Mpnd
entrez
68047
canonical
uniprot
Q3TV65
canonical
ensembl
ENSMUSG00000003199
resolver
ensp
ENSMUSP00000119745
resolver
enst
ENSMUST00000149441
resolver
genesymbol
Mpnd
resolver
uniprot
Q3T9P5
resolver
uniprot
Q3UIC8
resolver
uniprot
Q8VEN1
resolver
uniprot_entry
MPND_MOUSE
resolver
uniprot_sec
Q3T9P5
resolver
uniprot_sec
Q3UIC8
resolver
uniprot_sec
Q8VEN1
resolver
amino_acid_sequence
MAAPESLSPGATAEEAPEEDEDDAEAEDPERGTGSGGRSGSLGGSGGGTAGPGMALGGALTRRAVTLRVLLKDELLEPGEGVLSIYYLGRKFTGDLQLDGRIVWQETGQVFNSPSAWATHCKKLVNPAKKSGCGWASVKYKGQKLDKYKAAWLRRHQLHMPVATADESPTSEGEEEELLLEEEEEDVLAGVSSEDKGHRPPGKGSLEPEATPPGKRMDKVPVPIRYCMLGSRDSARNPHTLVEVTSFAAINKFQPFNVAVSSNVLFLLDFHCHLTRSEVVGYLGGRWDINNQMLTVLRAFPCRSRLGDTDTAATVEEEIYQVLFLRGLSLVGWYHSHPHSPAVPSLQDIDAQMEYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKICPFWVMPPPEQRPSDYGIPMDVEMAYVQDSFLTNDVLQEMVMLAEFYKGAPDLVKFQEAWSPEHTYLDKLKMSLASRTPKDQGMCHVLEQVCSVLKQGS
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: Probable protease (By similarity). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (By similarity). Binds only double strand DNA (dsDNA) in a sequence-independent manner (PubMed:36834777). {ECO:0000250|UniProtKB:Q5VVJ2, ECO:0000250|UniProtKB:Q8N594, ECO:0000269|PubMed:36834777}.
uniprot
proteins
mass_dalton
53376
uniprot
proteins
mutagenesis
MUTAGEN 113; /note="S->A: Lost DNA binding."; /evidence="ECO:0000269|PubMed:36834777"; MUTAGEN 115; /note="S->A: Lost DNA binding."; /evidence="ECO:0000269|PubMed:36834777"; MUTAGEN 135; /note="W->A: Lost DNA binding."; /evidence="ECO:0000269|PubMed:36834777
uniprot
proteins
post_translational_modification
PTM: Degraded following binding to N(6)-methyladenosine methylated DNA (m6A). {ECO:0000250|UniProtKB:Q8N594}.
uniprot
proteins
protein_family
Peptidase M67 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
36834777
uniprot
proteins
sequence_length
487
uniprot
proteins