BID
entrez
637
canonical
uniprot
P55957
canonical
ensembl
ENSG00000015475
resolver
ensp
ENSP00000318822
resolver
ensp
ENSP00000382667
resolver
ensp
ENSP00000382669
resolver
ensp
ENSP00000449236
resolver
ensp
ENSP00000477773
resolver
ensp
ENSP00000480414
resolver
genesymbol
BID
resolver
hgnc
HGNC:1050
resolver
uniprot
A8ASI8
resolver
uniprot
B2ZP79
resolver
uniprot
B3KT21
resolver
uniprot
Q549M7
resolver
uniprot
Q71T04
resolver
uniprot
Q7Z4M9
resolver
uniprot
Q8IY86
resolver
uniprot_entry
A8ASI8_HUMAN
resolver
uniprot_entry
B2ZP79_HUMAN
resolver
uniprot_entry
B3KT21_HUMAN
resolver
uniprot_entry
BID_HUMAN
resolver
uniprot_sec
Q549M7
resolver
uniprot_sec
Q71T04
resolver
uniprot_sec
Q7Z4M9
resolver
uniprot_sec
Q8IY86
resolver
amino_acid_sequence
MDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNGMD
uniprot
proteins
function
FUNCTION: Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity). {ECO:0000250|UniProtKB:P70444, ECO:0000269|PubMed:14583606}.; FUNCTION: [BH3-interacting domain death agonist p15]: Induces caspase activation and apoptosis (PubMed:15661737, PubMed:32029622). Translocates to mitochondria following cleavage and disrupts the outer mitochondrial membrane leading to the release of cytochrome c (PubMed:10480954, PubMed:32029622, PubMed:9727491). {ECO:0000269|PubMed:10480954, ECO:0000269|PubMed:15661737, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:9727491}.; FUNCTION: [Isoform 1]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 2]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 3]: Does not induce apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 4]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.
uniprot
proteins
mass_dalton
21995
uniprot
proteins
post_translational_modification
PTM: [BH3-interacting domain death agonist]: TNF induces caspase-mediated cleavage into a major p15 and minor p13 and p11 products (PubMed:10480954, PubMed:32029622, PubMed:9727491). Cleaved by CASP6 or CASP8 into a major p15 and minor p13 products, leading to release of cytochrome c (PubMed:32029622). Also cleaved by GZMK to generate p15 (PubMed:10480954). {ECO:0000269|PubMed:10480954, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:9727491}.; PTM: [BH3-interacting domain death agonist p15]: Ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation. {ECO:0000269|PubMed:20392206}.
uniprot
proteins
pubmed
10089877
uniprot
proteins
pubmed
10480954
uniprot
proteins
pubmed
14583606
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15661737
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
20392206
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29531808
uniprot
proteins
pubmed
32029622
uniprot
proteins
pubmed
33106313
uniprot
proteins
pubmed
8918887
uniprot
proteins
pubmed
9721221
uniprot
proteins
pubmed
9727491
uniprot
proteins
sequence_length
195
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14583606}. Mitochondrion membrane {ECO:0000269|PubMed:14583606}. Mitochondrion outer membrane {ECO:0000269|PubMed:29531808}. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269|PubMed:14583606}.; SUBCELLULAR LOCATION: [BH3-interacting domain death agonist p15]: Mitochondrion membrane {ECO:0000269|PubMed:9727491}. Note=Translocates to mitochondria following cleavage. {ECO:0000269|PubMed:9727491}.; SUBCELLULAR LOCATION: [BH3-interacting domain death agonist p13]: Mitochondrion membrane {ECO:0000250|UniProtKB:P70444}. Note=Associated with the mitochondrial membrane. {ECO:0000250|UniProtKB:P70444}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:14583606}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:14583606}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion membrane {ECO:0000269|PubMed:14583606}. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively. {ECO:0000269|PubMed:14583606}.
uniprot
proteins