Slco1a5
entrez
108096
canonical
uniprot
Q91YY5
canonical
ensembl
ENSMUSG00000063975
resolver
ensp
ENSMUSP00000080116
resolver
ensp
ENSMUSP00000137607
resolver
enst
ENSMUST00000081380
resolver
enst
ENSMUST00000111825
resolver
genesymbol
Slco1a5
resolver
genesymbol_syn
Oatp1a5
resolver
genesymbol_syn
Oatp3
resolver
genesymbol_syn
Slc21a7
resolver
uniprot
A0A0G2JDD1
resolver
uniprot
Q91XS2
resolver
uniprot_entry
A0A0G2JDD1_MOUSE
resolver
uniprot_entry
SO1A5_MOUSE
resolver
uniprot_sec
Q91XS2
resolver
amino_acid_sequence
MGETEKRIATHGVRCFSKIKMFLLALTCAYVSKSLSGIYMNSMLTQIERQFDIPTSIVGLINGSFEIGNLLLIILVSYFGTKLHRPIMIGIGCVIMGLGCFLMSLPHFLMGRYEYETTISPTSNLSSNSFLCMENRTQTLKPTQDPAECVKEMKSLMWIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGILESGKMIGPIVGLLLGSFCARIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLPKEGLQDNVARTENDKEEKHREKAKEENRGITKDFLPFMKSLSCNPIYMLLILTSVLQINAFINMFTFLPKYLEQQYGKSTSEVVLLIGVCNLPPICIGYLLIGFIMKKFRITVKKAAYMAFCLSLFEYLLSYFHFMISCDNFQVAGLTTSYEGVQHPLYVENKVLADCNTRCSCLTNTWDPVCGDNGLSYMSACLAGCEKSVGMGTHMVFQNCSCIQSSGNSSAVLGLCKKGPECANKLQYFLIMSVIGSFIYSITAIPGYMVLLRCIKSEEKSLGIGLHAFCTRIFAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRIYNINNFRRIYLVLPAALRGSSYLPAFFILILMRKFQLPGEMYSSETELADMKQTVKKSECTDVHGIPKVENDGELKTKL
uniprot
proteins
function
FUNCTION: Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), estrone 3-sulfate and prostaglandin E2, at the plasma membrane. Responsible for intestinal absorption of bile acids. Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine) (By similarity). Plays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells (PubMed:15255953). May also play a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (By similarity). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (By similarity). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity). {ECO:0000250|UniProtKB:O88397, ECO:0000250|UniProtKB:P46721, ECO:0000303|PubMed:15255953}.
uniprot
proteins
mass_dalton
74663
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
11093941
uniprot
proteins
pubmed
15255953
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
670
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P46721}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000250|UniProtKB:P46721}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..40; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 60..80; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 87..111; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 156..184; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 243..267; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 312..333; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 354..377; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 382..405; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 514..536; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 546..571; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 606..623; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins