SRRM4
entrez
84530
canonical
uniprot
A7MD48
canonical
ensembl
ENSG00000139767
resolver
ensp
ENSP00000267260
resolver
enst
ENST00000267260
resolver
genesymbol
SRRM4
resolver
genesymbol_syn
KIAA1853
resolver
hgnc
HGNC:29389
resolver
uniprot
A8K5P6
resolver
uniprot
B2RZH7
resolver
uniprot
Q7Z5F0
resolver
uniprot
Q96JH4
resolver
uniprot
V5T9A0
resolver
uniprot_entry
SRRM4_HUMAN
resolver
uniprot_entry
V5T9A0_HUMAN
resolver
uniprot_sec
A8K5P6
resolver
uniprot_sec
B2RZH7
resolver
uniprot_sec
Q7Z5F0
resolver
uniprot_sec
Q96JH4
resolver
amino_acid_sequence
MASVQQGEKQLFEKFWRGTFKAVATPRPESIIVASITARKPLPRTEPQNNPVVPAQDGPSEKLGQHLATEPLGTNSWERDKTCRELGATRGHSASHDKDLTPPPSSRGKKKKKKSTRKKRRRSSSYSPSPVKKKKKKSSKKHKRRRSFSKKRRHSSSSPKSKRRDEKRHKKQSRSRPRKSHRHRHHRCPSRSQSSESRPSSCESRHRGRSPEEGQKSRRRHSRRCSKTLCKDSPEAQSSRPPSQPLQMLGYLSARGVITGSGSAADLFTKTASPLTTSRGRSQEYDSGNDTSSPPSTQTSSARSRGQEKGSPSGGLSKSRELNSGNTSDSGNSFTTSSPQNKGAMLENLSPTSRGRESRGFQSPCLECAEVKKSSLVPSTARSSPMKGCSRSSSYASTRSSSHSSRSPNPRASPRYTQSRSTSSEKRSYSRSPSYSSKSGKRSPPSRSSRSRRSPSYSRYSPSRERDPKYSEKDSQQRERERARRRRRSYSPMRKRRRDSPSHLEARRITSARKRPIPYYRPSPSSSGSLSSTSSWYSSSSSRSASRSYSRSRSRSRSRRRSRTRTSSSSSSRSPSPGSRSRSRSRSRSRSRSRSQSRSYSSADSYSSTRR
uniprot
proteins
function
FUNCTION: Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity). Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells (PubMed:30684677). Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions (By similarity). {ECO:0000250|UniProtKB:Q8BKA3, ECO:0000269|PubMed:30684677}.
uniprot
proteins
mass_dalton
68559
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q8BKA3}.
uniprot
proteins
protein_family
NSR100 family
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
12800201
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19737518
uniprot
proteins
pubmed
30684677
uniprot
proteins
sequence_length
611
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BKA3}.
uniprot
proteins