Rnf139
entrez
75841
canonical
uniprot
Q7TMV1
canonical
ensembl
ENSMUSG00000037075
resolver
ensp
ENSMUSP00000046467
resolver
enst
ENSMUST00000036904
resolver
genesymbol
Rnf139
resolver
uniprot
A0A0R4J0K8
resolver
uniprot
Q8BZU9
resolver
uniprot_entry
A0A0R4J0K8_MOUSE
resolver
uniprot_entry
RN139_MOUSE
resolver
uniprot_sec
Q8BZU9
resolver
amino_acid_sequence
MAAVGPPQQQVRMAQQQVWAALEVALRVPCLYIIDAIFNSYYDSSQSRFCIGLQIFLRLLGIVVSSIVLILSQRSLFKFYMYSSAFLLAATSVLVNYYAALHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLQIQSIYSQLMILNILVPIIGLITELPLHIRETVVLMSSLILIFNTVLVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRITTQATVLMYILRMANETESFFISWDDFWDVICNLIISGCDSTLTVLGMSAVISSIAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFHRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYFVRSTGNIIEFIFGVVMFGNGAYTMMFESGSKIRACMMCLHAYFNIYLQVKNGWKTFMNRRTAVKKINSLPEIKGSHLQEIDDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDEIKDNSNASNNNGFIAPNENPNPEEALREDAAGSDRELNEDDSTDCDDDAQRERNGGIQHTGAAAAAAEFNDDTD
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Involved in the sterol-accelerated degradation of HMGCR. This is achieved through binding to INSIG1 and/or INSIG2 at the ER membrane. In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. {ECO:0000250|UniProtKB:Q8WU17}.
uniprot
proteins
mass_dalton
76185
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8WU17}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. Ubiquitination is induced by sterol and leads to ist degradation via the ubiquitin-proteasome pathway. {ECO:0000250|UniProtKB:Q8WU17}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
668
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8WU17}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8WU17}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..71; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 85..105; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 125..145; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 154..174; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 178..198; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 323..343; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 356..376; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 390..410; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 420..440; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins