COXFA4L3
entrez
84419
canonical
uniprot
Q9C002
canonical
ensembl
ENSG00000166920
resolver
ensp
ENSP00000341610
resolver
ensp
ENSP00000379887
resolver
ensp
ENSP00000630432
resolver
enst
ENST00000344300
resolver
enst
ENST00000396650
resolver
enst
ENST00000960373
resolver
genesymbol
COXFA4L3
resolver
genesymbol_syn
C15orf48
resolver
genesymbol_syn
MOCCI
resolver
genesymbol_syn
NMES1
resolver
hgnc
HGNC:29898
resolver
uniprot_entry
CX4L3_HUMAN
resolver
amino_acid_sequence
MSFFQLLMKRKELIPLVVFMTVAAGGASSFAVYSLWKTDVILDRKKNPEPWETVDPTVPQKLITINQQWKPIEELQNVQRVTK
uniprot
proteins
function
FUNCTION: Mitochondrial small peptide that orchestrates a two-pronged immunoregulatory mechanism in response to inflammatory stimuli. Replaces the canonical cytochrome c oxidase subunit COXFA4 in mitochondrial complex IV and targets it to degradation, attenuating mitochondrial respiration, reducing membrane potential as well as ROS generation and modulates innate immune signaling (PubMed:33837217, PubMed:34878835). Additionally, initiates stress-independent autophagy by lowering ATP levels, activating AMPK-ULK1 signaling, boosting glutathione production, and thereby mitigating oxidative stress and supporting immune tolerance (PubMed:38296961). {ECO:0000269|PubMed:33837217, ECO:0000269|PubMed:34878835, ECO:0000269|PubMed:38296961}.
uniprot
proteins
mass_dalton
9617
uniprot
proteins
protein_family
Complex IV COXFA4 subunit family
uniprot
proteins
pubmed
12209954
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
33837217
uniprot
proteins
pubmed
34878835
uniprot
proteins
pubmed
38296961
uniprot
proteins
sequence_length
83
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:33837217, ECO:0000305|PubMed:38296961}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..35; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins