Brd7
entrez
26992
canonical
uniprot
O88665
canonical
ensembl
ENSMUSG00000031660
resolver
ensp
ENSMUSP00000034085
resolver
enst
ENSMUST00000034085
resolver
genesymbol
Brd7
resolver
genesymbol_syn
Bp75
resolver
uniprot
Q3UQ56
resolver
uniprot
Q3UU06
resolver
uniprot
Q9CT78
resolver
uniprot_entry
BRD7_MOUSE
resolver
uniprot_sec
Q3UQ56
resolver
uniprot_sec
Q3UU06
resolver
uniprot_sec
Q9CT78
resolver
amino_acid_sequence
MGKKHKKHKSDRHFYEEYVEKPLKLVLKVGGSEVTELSTGSSGHDSSLFEDRSDHDKHKDRKRKKRKKGEKQAPGEEKGRKRRRVKEDKKKRDRDRAENEVDRDLQCHVPIRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPVTDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYYKAAKKLLHSGMKILSQERIQSLKQSIDFMSDLQKTRKQKERTDACQSGEDSGCWQREREDSGDAETQAFRSPAKDNKRKDKDVLEDKWRSSNSEREHEQIERVVQESGGKLTRRLANSQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDKRNRVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPNNFSISEFLATCQDYPYVMADSLLDVLTKGGHSRSLQDLDMSSPEDEGQTRALDTAKEAEITQIEPTGRLESSSQDRLTALQAVTTFGAPAEVFDSEEAEVFQRKLDETTRLLRELQEAQNERLSTRPPPNMICLLGPSYREMYLAEQVTNNLKELTQQVTPGDVVSIHGVRKAMGISVPSPIVGNSFVDLTGECEEPKETSTAECGPDAS
uniprot
proteins
function
FUNCTION: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase (By similarity). Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR. {ECO:0000250, ECO:0000269|PubMed:12941796, ECO:0000269|PubMed:18809673, ECO:0000269|PubMed:19909775}.
uniprot
proteins
mass_dalton
74000
uniprot
proteins
pubmed
10526152
uniprot
proteins
pubmed
12941796
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18809673
uniprot
proteins
pubmed
19909775
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
651
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10526152, ECO:0000269|PubMed:19909775}. Chromosome {ECO:0000250|UniProtKB:Q9NPI1}.
uniprot
proteins