Dstyk
entrez
304791
canonical
uniprot
Q6XUX2
canonical
ensembl
ENSRNOG00000021298
resolver
ensp
ENSRNOP00000004810
resolver
genesymbol
Dstyk
resolver
genesymbol_syn
Ripk5
resolver
uniprot_entry
DUSTY_RAT
resolver
amino_acid_sequence
MEADGQSWSGESVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHSHSCPSSPAGGGAAELGPAGDVAAAPLPAGQLSCISFPPMEEKYLQQIVDHLPCILILGQDCNAKCQLLNLLLAVRVLPTLKLDSDESCKLRRLRFTYGTRTQVSLALPGQYELVHTLASHQDNWETIPEEDLEVQEDSEDTARVLADLEVTMHHALLQEVDIVVAPCHSHRPAVDVLSDLANDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPTLEIIRSSSGRADSERSPLSGQLMDLGYLSSSHRNCMASDQDCRAQSMLVEQSEKLRQLSTFSHQLLQTRLVDAAKALNAVHSHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAANMEFKDVIVPENGETVGTREIKSCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVNPPTITLEWKRKVAQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSVAVLLIMERLHRDLYTGLKAGLSLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSIKLPEAFERCASKDHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPSKRPLLGIVQPILRSIMDRLCKCDSERPSRGLDDST
uniprot
proteins
ec_number
2.7.12.1
uniprot
proteins
function
FUNCTION: Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. Involved in normal skeletal segmentation and spine formation, via positively regulating late-stage endosomal trafficking in notochord cells (By similarity). Required for normal spatial learning and memory, independent of normal brain development (By similarity). May be required for normal urinary tract and kidney formation (By similarity). {ECO:0000250|UniProtKB:Q4VSN1, ECO:0000250|UniProtKB:Q6XUX1, ECO:0000250|UniProtKB:Q6XUX3}.
uniprot
proteins
mass_dalton
104898
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
17123648
uniprot
proteins
sequence_length
927
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6XUX1}. Cell membrane {ECO:0000250|UniProtKB:Q6XUX1}. Apical cell membrane {ECO:0000250|UniProtKB:Q6XUX1}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q6XUX1}. Cell junction {ECO:0000250|UniProtKB:Q6XUX1}. Note=Detected in basolateral and apical membranes of all tubular epithelia. Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane. {ECO:0000250|UniProtKB:Q6XUX1}.
uniprot
proteins