NMB
entrez
4828
canonical
uniprot
P08949
canonical
ensembl
ENSG00000197696
resolver
ensembl
ENSG00000291631
resolver
ensp
ENSP00000353664
resolver
ensp
ENSP00000378089
resolver
ensp
ENSP00000797613
resolver
genesymbol
NMB
resolver
hgnc
HGNC:7842
resolver
uniprot
Q96A06
resolver
uniprot
Q96HH5
resolver
uniprot_entry
NMB_HUMAN
resolver
uniprot_sec
Q96A06
resolver
uniprot_sec
Q96HH5
resolver
amino_acid_sequence
MARRAGGARMFGSLLLFALLAAGVAPLSWDLPEPRSRASKIRVHSRGNLWATGHFMGKKSLEPSSPSPLGTAPHTSLRDQRLQLSHDLLGILLLKKALGVSLSRPAPQIQYRRLLVQILQK
uniprot
proteins
function
FUNCTION: Stimulates smooth muscle contraction (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (By similarity). Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity). {ECO:0000250|UniProtKB:P01297, ECO:0000250|UniProtKB:Q9CR53, ECO:0000269|PubMed:31601264}.
uniprot
proteins
mass_dalton
13252
uniprot
proteins
protein_family
Bombesin/neuromedin-B/ranatensin family
uniprot
proteins
pubmed
10544247
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
2458345
uniprot
proteins
pubmed
31601264
uniprot
proteins
sequence_length
121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9CR53}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q9CR53}. Note=In neurons of the retrotrapezoid nucleus//parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex. {ECO:0000250|UniProtKB:Q9CR53}.
uniprot
proteins