BCCIP
entrez
56647
canonical
uniprot
Q9P287
canonical
ensembl
ENSG00000107949
resolver
ensp
ENSP00000278100
resolver
ensp
ENSP00000299130
resolver
ensp
ENSP00000357748
resolver
genesymbol
BCCIP
resolver
genesymbol_syn
TOK1
resolver
hgnc
HGNC:978
resolver
uniprot
B3KP45
resolver
uniprot
Q8ND15
resolver
uniprot
Q96GC4
resolver
uniprot
Q9P288
resolver
uniprot_entry
BCCIP_HUMAN
resolver
uniprot_sec
B3KP45
resolver
uniprot_sec
Q8ND15
resolver
uniprot_sec
Q96GC4
resolver
uniprot_sec
Q9P288
resolver
amino_acid_sequence
MASRSKRRAVESGVPQPPDPPVQRDEEEEKEVENEDEDDDDSDKEKDEEDEVIDEEVNIEFEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHIGSVIKQTDVSEDSNDDMDEDEVFGFISLLNLTERKGTQCVEQIQELVLRFCEKNCEKSMVEQLDKFLNDTTKPVGLLLSERFINVPPQIALPMYQQLQKELAGAHRTNKPCGKCYFYLLISKTFVEAGKNNSKKKPSNKKKAALMFANAEEEFFYEKAILKFNYSVQEESDTCLGGKWSFDDVPMTPLRTVMLIPGDKMNEIMDKLKEYLSV
uniprot
proteins
function
FUNCTION: During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). {ECO:0000269|PubMed:10878006, ECO:0000269|PubMed:14726710, ECO:0000269|PubMed:15539944, ECO:0000269|PubMed:15713648, ECO:0000269|PubMed:17947333, ECO:0000269|PubMed:28394342}.
uniprot
proteins
mass_dalton
35979
uniprot
proteins
protein_family
BCP1 family
uniprot
proteins
pubmed
10878006
uniprot
proteins
pubmed
11313963
uniprot
proteins
pubmed
12527204
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14726710
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15539944
uniprot
proteins
pubmed
15713648
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17947333
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18440304
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28394342
uniprot
proteins
pubmed
28931820
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10878006, ECO:0000269|PubMed:11313963, ECO:0000269|PubMed:15713648}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28394342}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28394342}. Note=Colocalizes with BRCA2 in discrete nuclear foci (PubMed:15713648). In interphase, preferential localizes to the mother centriole (PubMed:28394342). Recruited to the spindle pole matrix and centrosome by microtubules and dynein/dynactin activity (PubMed:28394342). {ECO:0000269|PubMed:15713648, ECO:0000269|PubMed:28394342}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28394342}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28394342}. Note=Isoform 1/beta tends to be less abundant at, and less strongly associated with, centrosomes than isoform 2/alpha. {ECO:0000269|PubMed:28394342}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28394342}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28394342}. Note=Isoform 2/alpha tends to be more abundant at, and more strongly associated with, centrosomes than isoform 1/beta. {ECO:0000269|PubMed:28394342}.
uniprot
proteins