LBP
entrez
3929
canonical
uniprot
P18428
canonical
ensembl
ENSG00000129988
resolver
ensp
ENSP00000217407
resolver
enst
ENST00000217407
resolver
genesymbol
LBP
resolver
hgnc
HGNC:6517
resolver
uniprot
B2R938
resolver
uniprot
O43438
resolver
uniprot
Q8TCF0
resolver
uniprot
Q92672
resolver
uniprot
Q9H403
resolver
uniprot
Q9UD66
resolver
uniprot_entry
LBP_HUMAN
resolver
uniprot_entry
Q8TCF0_HUMAN
resolver
uniprot_sec
B2R938
resolver
uniprot_sec
O43438
resolver
uniprot_sec
Q92672
resolver
uniprot_sec
Q9H403
resolver
uniprot_sec
Q9UD66
resolver
amino_acid_sequence
MGALARALPSILLALLLTSTPEALGANPGLVARITDKGLQYAAQEGLLALQSELLRITLPDFTGDLRIPHVGRGRYEFHSLNIHSCELLHSALRPVPGQGLSLSISDSSIRVQGRWKVRKSFFKLQGSFDVSVKGISISVNLLLGSESSGRPTVTASSCSSDIADVEVDMSGDLGWLLNLFHNQIESKFQKVLESRICEMIQKSVSSDLQPYLQTLPVTTEIDSFADIDYSLVEAPRATAQMLEVMFKGEIFHRNHRSPVTLLAAVMSLPEEHNKMVYFAISDYVFNTASLVYHEEGYLNFSITDDMIPPDSNIRLTTKSFRPFVPRLARLYPNMNLELQGSVPSAPLLNFSPGNLSVDPYMEIDAFVLLPSSSKEPVFRLSVATNVSATLTFNTSKITGFLKPGKVKVELKESKVGLFNAELLEALLNYYILNTFYPKFNDKLAEGFPLPLLKRVQLYDLGLQIHKDFLFLGANVQYMRV
uniprot
proteins
function
FUNCTION: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:24120359, PubMed:7517398). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:24120359, PubMed:7517398). {ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:20133493, ECO:0000269|PubMed:24120359, ECO:0000269|PubMed:7517398, ECO:0000305|PubMed:17481951}.
uniprot
proteins
mass_dalton
53384
uniprot
proteins
protein_family
BPI/LBP family
uniprot
proteins
protein_family
BPI/LBP/Plunc superfamily
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1698311
uniprot
proteins
pubmed
17481951
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
20133493
uniprot
proteins
pubmed
2402637
uniprot
proteins
pubmed
24120359
uniprot
proteins
pubmed
7517398
uniprot
proteins
pubmed
9240454
uniprot
proteins
pubmed
9441745
uniprot
proteins
sequence_length
481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2402637, ECO:0000269|PubMed:24120359, ECO:0000269|PubMed:7517398}. Cytoplasmic granule membrane {ECO:0000250|UniProtKB:P17213}. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. {ECO:0000250|UniProtKB:P17213}.
uniprot
proteins