BMP10
entrez
27302
canonical
uniprot
O95393
canonical
ensembl
ENSG00000163217
resolver
ensp
ENSP00000295379
resolver
enst
ENST00000295379
resolver
genesymbol
BMP10
resolver
hgnc
HGNC:20869
resolver
uniprot
Q53R17
resolver
uniprot
Q6NTE0
resolver
uniprot_entry
BMP10_HUMAN
resolver
uniprot_sec
Q53R17
resolver
uniprot_sec
Q6NTE0
resolver
amino_acid_sequence
MGSLVLTLCALFCLAAYLVSGSPIMNLEQSPLEEDMSLFGDVFSEQDGVDFNTLLQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGCR
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in BMP10 may be a cause of congenital heart defects, a wide spectrum of cardiovascular malformations resulting from anomalous development of the heart, cardiac valves, and endo-thoracic large vessels. {ECO:0000269|PubMed:38322548}.
uniprot
proteins
function
FUNCTION: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. {ECO:0000269|PubMed:16049014, ECO:0000269|PubMed:17068149, ECO:0000269|PubMed:20608934}.
uniprot
proteins
mass_dalton
48047
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16049014
uniprot
proteins
pubmed
17068149
uniprot
proteins
pubmed
18339631
uniprot
proteins
pubmed
20608934
uniprot
proteins
pubmed
21737454
uniprot
proteins
pubmed
38322548
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins