SLC25A51
entrez
92014
canonical
uniprot
Q9H1U9
canonical
ensembl
ENSG00000122696
resolver
ensp
ENSP00000242275
resolver
ensp
ENSP00000366945
resolver
ensp
ENSP00000554054
resolver
ensp
ENSP00000554055
resolver
ensp
ENSP00000599174
resolver
ensp
ENSP00000599175
resolver
ensp
ENSP00000599176
resolver
ensp
ENSP00000599177
resolver
ensp
ENSP00000599178
resolver
ensp
ENSP00000620434
resolver
ensp
ENSP00000620435
resolver
enst
ENST00000242275
resolver
enst
ENST00000377716
resolver
enst
ENST00000883995
resolver
enst
ENST00000883996
resolver
enst
ENST00000929115
resolver
enst
ENST00000929116
resolver
enst
ENST00000929117
resolver
enst
ENST00000929118
resolver
enst
ENST00000929119
resolver
enst
ENST00000950375
resolver
enst
ENST00000950376
resolver
genesymbol
SLC25A51
resolver
genesymbol_syn
MCART1
resolver
hgnc
HGNC:23323
resolver
uniprot_entry
S2551_HUMAN
resolver
amino_acid_sequence
MMDSEAHEKRPPILTSSKQDISPHITNVGEMKHYLCGCCAAFNNVAITFPIQKVLFRQQLYGIKTRDAILQLRRDGFRNLYRGILPPLMQKTTTLALMFGLYEDLSCLLHKHVSAPEFATSGVAAVLAGTTEAIFTPLERVQTLLQDHKHHDKFTNTYQAFKALKCHGIGEYYRGLVPILFRNGLSNVLFFGLRGPIKEHLPTATTHSAHLVNDFICGGLLGAMLGFLFFPINVVKTRIQSQIGGEFQSFPKVFQKIWLERDRKLINLFRGAHLNYHRSLISWGIINATYEFLLKVI
uniprot
proteins
function
FUNCTION: Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria (PubMed:32906142, PubMed:33087354, PubMed:33262325). Mitochondrial NAD(+) is required for glycolysis and mitochondrial respiration (PubMed:32906142, PubMed:33087354, PubMed:33262325). Compared to SLC25A52, SLC25A51-mediated transport is essential for the import of NAD(+) in mitochondria (PubMed:32906142). The transport mechanism, uniport or antiport, its electrogenicity and substrate selectivity, remain to be elucidated. {ECO:0000269|PubMed:32906142, ECO:0000269|PubMed:33262325}.
uniprot
proteins
mass_dalton
33672
uniprot
proteins
mutagenesis
MUTAGEN 91; /note="K->A: Impaired import of NAD(+) into mitochondria."; /evidence="ECO:0000269|PubMed:33087354"; MUTAGEN 278; /note="R->A: Impaired import of NAD(+) into mitochondria."; /evidence="ECO:0000269|PubMed:33087354
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
32906142
uniprot
proteins
pubmed
33087354
uniprot
proteins
pubmed
33262325
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:33087354, ECO:0000305|PubMed:32906142}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 85..105; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 116..135; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 215..235; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 268..289; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins