Tmem161b
entrez
72745
canonical
uniprot
Q8C2L6
canonical
ensembl
ENSMUSG00000035762
resolver
ensp
ENSMUSP00000055208
resolver
ensp
ENSMUSP00000152891
resolver
enst
ENSMUST00000057495
resolver
enst
ENSMUST00000225069
resolver
genesymbol
Tmem161b
resolver
uniprot
A0A286YCA7
resolver
uniprot
Q8BT72
resolver
uniprot_entry
A0A286YCA7_MOUSE
resolver
uniprot_entry
T161B_MOUSE
resolver
uniprot_sec
Q8BT72
resolver
amino_acid_sequence
MGVIGIQLVVTMVMASVMQKIIPHYSLARWLLCNGSLRWYQHPSEEELRILAGKQQKGKSKKDRKYNGHIENKPLTIPKDIDLHLETKSVTEVDTLALHYFPEYQWLVDFTVAATIVYLVTEVYYSFMKPTQEMNISLVWCLLVLSFAIKVLFSLTTHYFKVEDGGERSVCVTFGFFFFVKAMAVLIVTENYLEFGLETGFTNFSDSAMQFLEKQGLESQGPVSKLTFKFFLAVFCSLIGAFLTFPGLRLAQMHLDALNMATEKITQTLLHINFLAPLFMVLLWVKPITKDYIMNPPLGRESVPLMTEATFDTLRLWLIILLCVLRLAMMRSHLQAYLNLAQKCVDQMKKEAGRISTVELQKMVARVFYYLCVIALQYVAPLVMLLHMTLLLKTLGNHSWGIYPEAAFPLPVDNNLPANSAYPELPSPDGKMKVTVTQITVALSSLKNIFTPLLFRGLLSFLTWWIAACLFSTSLFGLFYHQYLTVA
uniprot
proteins
function
FUNCTION: Essential for maintaining normal cardiac rhythm in the developing heart and for neonatal survival (PubMed:33597309). Inhibits potassium and calcium currents in the cardiomyocytes, this assists in timely action potential repolarization and thereby maintains normal cardiac rhythm (PubMed:33597309). {ECO:0000269|PubMed:33597309}.
uniprot
proteins
mass_dalton
55467
uniprot
proteins
protein_family
TMEM161 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
33597309
uniprot
proteins
sequence_length
487
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7SY10}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 107..127; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 228..248; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 367..387; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 459..479; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins