Lrrc8c
entrez
289443
canonical
uniprot
Q498T9
canonical
ensembl
ENSRNOG00000065000
resolver
ensembl
ENSRNOG00055025124
resolver
ensembl
ENSRNOG00060010474
resolver
ensembl
ENSRNOG00065012562
resolver
ensp
ENSRNOP00000082962
resolver
ensp
ENSRNOP00055035321
resolver
ensp
ENSRNOP00060013763
resolver
ensp
ENSRNOP00065015691
resolver
enst
ENSRNOT00000104559
resolver
enst
ENSRNOT00055043307
resolver
enst
ENSRNOT00060017707
resolver
enst
ENSRNOT00065020421
resolver
genesymbol
Lrrc8c
resolver
uniprot_entry
LRC8C_RAT
resolver
amino_acid_sequence
MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSLSNVSQTVINTTPLPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMNRSNTIQSGPEGSLVKSQSLKSIPEKFVVDKSTAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWYNSIAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDIKGNHFEVLPPELGDCRALKRAGLVVEDALFETLPSDVREQMKAD
uniprot
proteins
function
FUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:28833202). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:28833202). {ECO:0000250|UniProtKB:Q8TDW0, ECO:0000269|PubMed:28833202}.
uniprot
proteins
mass_dalton
92463
uniprot
proteins
protein_family
LRRC8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
28833202
uniprot
proteins
sequence_length
803
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28833202}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TDW0}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8TDW0}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane. {ECO:0000250|UniProtKB:Q8TDW0}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q80WG5"; TRANSMEM 126..146; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q80WG5"; TRANSMEM 267..287; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q80WG5"; TRANSMEM 321..341; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q80WG5
uniprot
proteins