Mgme1
entrez
74528
canonical
uniprot
Q9CXC3
canonical
ensembl
ENSMUSG00000027424
resolver
ensp
ENSMUSP00000028910
resolver
ensp
ENSMUSP00000105654
resolver
ensp
ENSMUSP00000105655
resolver
ensp
ENSMUSP00000241842
resolver
enst
ENSMUST00000028910
resolver
enst
ENSMUST00000110027
resolver
enst
ENSMUST00000110028
resolver
genesymbol
Mgme1
resolver
uniprot
A2ANA5
resolver
uniprot
Q3TIC0
resolver
uniprot
Q543Z8
resolver
uniprot_entry
MGME1_MOUSE
resolver
uniprot_sec
A2ANA5
resolver
uniprot_sec
Q3TIC0
resolver
uniprot_sec
Q543Z8
resolver
amino_acid_sequence
MKLPLTFCRLLSRLNRFSVKASPPVSFSTFSYLCSQKKKNSYEAVDQAKYSRLVRSVLSRGPAQTPESLFKEDDVLYGPVSKHKAAEPEPQARVPQHCFPIFNEERTGKPHTDASSSPLKIPLQRNSIPSVTRILQQTMPPEQSFFLERWKERMVLELGEDGFAEYTSNVFLQGKQFHKALESILSPQENLTGGEEHPQCGYIESIQHILTEISGVQALESAVQHEALKYVGLLDCVAEYRGKLCVIDWKTSEKPKPLIRNTYDNPLQVVAYMGAVNHDAHYSFQVQCGLIVVAYKDGSPAHPHFMDEELCSKYWAKWLLRLEEYTEKQKNLSAPEPA
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endonuclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair (By similarity). Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells. {ECO:0000255|HAMAP-Rule:MF_03030, ECO:0000269|PubMed:23434322}.
uniprot
proteins
mass_dalton
38391
uniprot
proteins
protein_family
MGME1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23434322
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03030}.
uniprot
proteins