Herc6
entrez
67138
canonical
uniprot
F2Z461
canonical
ensembl
ENSMUSG00000029798
resolver
ensp
ENSMUSP00000031817
resolver
enst
ENSMUST00000031817
resolver
genesymbol
Herc6
resolver
uniprot
Q3UEA7
resolver
uniprot
Q9CU70
resolver
uniprot_entry
HERC6_MOUSE
resolver
uniprot_sec
Q3UEA7
resolver
uniprot_sec
Q9CU70
resolver
amino_acid_sequence
MYFSWAAGSRKPRRLKAGTSGIELLQAASGEHHSLLLFSNHRVYSCGDNSWGQLGQRRDQSTERPEPIQALNDLHVDLVSCGKEHSVAVCHKGKVFAWGAGSEGQLGIGEFKEISFMPTKIKALAGIKIIQVSCGHYHSLALSEDGHVFSWGRNSEGQLGLGKNSRSQAIPQKVKSLEGIPLAQVAAGGTHSFALSLTGTSFGWGSNRSGQLALSGNKVKEQIYKPHSIGALKNLSVIYISCGYEHTAVLTEEGQVFTFGGNSSGQLQPSPRSGQRGPQLIEGIGGRVSQIECASYHTIAYVYTTGQVVSLGRGPSHTSNPTHQEAPAENSDITCLLAAEDLVDIEVKDIFAGAHANFVTTRRVSHTRSTGVSMKILPEIIRINQSLVKKWRAANKRKDREGAKREISLIFSSSACLTASFLKKRDAGENNLIDVDLKLARDVFKKLTTEKWISSLITTCLEEYLLRDLPYSSPHQEALLVFLLLPECSIMQDPKNWKTLAFEFAKAIHKMGPQSLAFLRTCWASLEVSSLNILVQMLKKAIISQIQYGVATEQYITNIKVLLEVIKEVHKANCQLPESAFIINELSGIFNFDAEAGRMFIRHNDLDCTESSDMVVFSDFLFVFDLPSKIKLMKCDSFVKLMSEVMAFPEKMSSPPYLILKVRRSHLVEDTLRQLRQVEDFDLRKQLSVGFINEIRPEAGGVSSEFFHCIFEEMTDPKYEMFIYPEKGSSMWFPVNPKFEKSSYFLFGILCGLSLHNLKVINLPFPLALYKKLLNQKPSLEDLKELSLPLGRNLQEVLNCEAGDIEELHMYFSIYWDQKDVDLIPDGISVPVNETNKRDYVSKYVDYIFNISIKTIYEEFHRGFYKVCNWDIIRQFQPEELMTAIIGNATCDWKQFENNSKYKDGYDKSHPTILLFWKAFHDLTLDEKKKFLLFLTGCDRLHVKGLQNEGIVFRCSETFSEEDNPRSLTCHRMLDLPKYSSMRRMKEALQVAINNSTGFVSQE
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
function
FUNCTION: Major E3 ligase for ISG15 conjugation (PubMed:22272257, PubMed:38421872, PubMed:38652662, PubMed:40184173). Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner (By similarity). Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner (By similarity). Acts as a positive regulator of innate antiviral response in cells induced by interferon by mediating ISGylation of proteins involved in innate immunity, such as CGAS, IRF3, IFIH1/MDA5 and STING1 (PubMed:22272257, PubMed:38421872, PubMed:38652662, PubMed:40184173). Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response (By similarity). Also regulates innate antiviral response by mediating ISGylation of CGAS and STING1, thereby promoting activation of cGAS-STING signaling (By similarity). Catalyzes ISGylation of IFIH1/MDA5, promoting IFIH1/MDA5 oligomerization and immune signal transduction (PubMed:40184173). {ECO:0000250|UniProtKB:Q9UII4, ECO:0000269|PubMed:22272257, ECO:0000269|PubMed:38421872, ECO:0000269|PubMed:38652662, ECO:0000269|PubMed:40184173}.
uniprot
proteins
mass_dalton
112928
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22272257
uniprot
proteins
pubmed
38421872
uniprot
proteins
pubmed
38652662
uniprot
proteins
pubmed
40184173
uniprot
proteins
sequence_length
1003
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22272257}. Note=Exclusively cytoplasmic. {ECO:0000269|PubMed:22272257}.
uniprot
proteins