ARFIP1
entrez
27236
canonical
uniprot
P53367
canonical
ensembl
ENSG00000164144
resolver
ensp
ENSP00000296557
resolver
ensp
ENSP00000348360
resolver
ensp
ENSP00000384189
resolver
ensp
ENSP00000395083
resolver
ensp
ENSP00000561743
resolver
ensp
ENSP00000584127
resolver
genesymbol
ARFIP1
resolver
hgnc
HGNC:21496
resolver
uniprot
B4DS69
resolver
uniprot
B4E273
resolver
uniprot
D3DP06
resolver
uniprot
Q2M2X4
resolver
uniprot
Q3SYL4
resolver
uniprot
Q8N8M9
resolver
uniprot
Q9Y2X6
resolver
uniprot_entry
ARFP1_HUMAN
resolver
uniprot_entry
B4E273_HUMAN
resolver
uniprot_entry
Q8N8M9_HUMAN
resolver
uniprot_sec
B4DS69
resolver
uniprot_sec
D3DP06
resolver
uniprot_sec
Q2M2X4
resolver
uniprot_sec
Q3SYL4
resolver
uniprot_sec
Q9Y2X6
resolver
amino_acid_sequence
MAQESPKNSAAEIPVTSNGEVDDSREHSFNRDLKHSLPSGLGLSETQITSHGFDNTKEGVIEAGAFQGSPAPPLPSVMSPSRVAASRLAQQGSDLIVPAGGQRTQTKSGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQTLKQFHIKLKTPGVDAPSWLEEQ
uniprot
proteins
function
FUNCTION: Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:22981988, PubMed:9038142). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}.
uniprot
proteins
mass_dalton
41738
uniprot
proteins
mutagenesis
MUTAGEN 132; /note="S->A: Complete loss of phosphorylation by PRKD1."; /evidence="ECO:0000269|PubMed:22981988
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKD1; phosphorylation delocalizes ARFIP1 from the Golgi and disrupts its ability to inhibit the activity of ADP-ribosylation factor, an important component of the vesicle scission machinery. {ECO:0000269|PubMed:22981988}.
uniprot
proteins
pubmed
10413101
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21239483
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22981988
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30917996
uniprot
proteins
pubmed
9038142
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21239483, ECO:0000269|PubMed:30917996}.
uniprot
proteins