Aars2
entrez
224805
canonical
uniprot
Q14CH7
canonical
ensembl
ENSMUSG00000023938
resolver
ensp
ENSMUSP00000024733
resolver
enst
ENSMUST00000024733
resolver
genesymbol
Aars2
resolver
genesymbol_syn
Aarsl
resolver
genesymbol_syn
Gm89
resolver
genesymbol_syn
Kiaa1270
resolver
uniprot
Q68FH3
resolver
uniprot
Q69ZM9
resolver
uniprot_entry
SYAM_MOUSE
resolver
uniprot_sec
Q68FH3
resolver
uniprot_sec
Q69ZM9
resolver
amino_acid_sequence
MAVALAAAAGKLRRAIGRSCPWQPFSTEPGPPHGAAVRDAFLSFFRDRHGHRLVPSATVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVVNSQKCVRAGGRHNDLEDVGRDLSHHTFFEMLGNWAFGGEYFKEEACSMAWELLTQVYGIPEDRLWVSYFSGDSQTGLDPDLETRDIWLSLGVPASRVLSFGPQENFWEMGDTGPCGPCTEIHYDLAGGVGSPQLVELWNLVFMQHYREADGSLQLLPQRHVDTGMGLERLVAVLQGKRSTYDTDLFSPLLDAIHQSCGAPPYSGRVGAADEGRIDTAYRVVADHIRTLSVCIADGVSPGMSGAPLVLRRILRRAVRYSTEVLQAPPGFLGSLVPVVVETLGSAYPELEKNSVKIASLVSEDEAAFLASLQRGRRIIDRTVKRLGPSDLFPAEVAWSLSLSGNLGIPLDLVELMLEEKGVKLDTAGLEQLAQKEAQHRAQQAEADQEDRLCLDVHALEELHRQGIPTTDDSPKYNYTLHPNGDYEFGLCEARVLQLYSETGTAVASVGAGQRCGLLLDRTNFYAEQGGQASDRGYLVRTGQQDMLFPVAGAQLCGGFILHEAMAPERLQVGDQVQLYVDKAWRMGCMVKHTATHLLSWALRQTLGPTTEQRGSHLNPERLRFDVATQTLLTTEQLRTVESYVQEVVGQDKPVFMEEVPLAHTARIPGLRSLDEVYPDPVRVVSVGVPVAHALGPASQAAMHTSVELCCGTHLLSTGAVGDLVIIGERQLVKGITRLLAITGEQAQQAREVGQSLSQEVEAASERLSQGSRDLPEAHRLSKDIGRLTEVAESAVIPQWQRQELQTTLKMLQRRANTAIRKLEKGQATEKSQELLKRHSEGPLIVDTVSAESLSVLVKVVRQLCKQAPSISVLLLSPQPTGSVLCACQVAQDATPTFTAEAWALAVCSHMGGKAWGSRVVAQGTGHTADLEAALGTARAYALSQL
uniprot
proteins
ec_number
6.-.-.-
uniprot
proteins
ec_number
6.1.1.7
uniprot
proteins
function
FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as CGAS (PubMed:39322678). Acts as an inhibitor of cGAS/STING signaling by catalyzing lactylation of CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:39322678). {ECO:0000255|HAMAP-Rule:MF_03133, ECO:0000269|PubMed:39322678}.
uniprot
proteins
mass_dalton
106783
uniprot
proteins
protein_family
Class-II aminoacyl-tRNA synthetase family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
39322678
uniprot
proteins
sequence_length
980
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion.
uniprot
proteins