PNO1
entrez
56902
canonical
uniprot
Q9NRX1
canonical
ensembl
ENSG00000115946
resolver
ensp
ENSP00000263657
resolver
ensp
ENSP00000769500
resolver
ensp
ENSP00000789952
resolver
enst
ENST00000263657
resolver
genesymbol
PNO1
resolver
hgnc
HGNC:32790
resolver
uniprot
A8K6Q0
resolver
uniprot
Q53G13
resolver
uniprot
Q8WVB8
resolver
uniprot_entry
PNO1_HUMAN
resolver
uniprot_sec
A8K6Q0
resolver
uniprot_sec
Q53G13
resolver
uniprot_sec
Q8WVB8
resolver
amino_acid_sequence
MESEMETQSARAEEGFTQVTRKGGRRAKKRQAEQLSAAGEGGDAGRMDTEEARPAKRPVFPPLCGDGLLSGKEETRKIPVPANRYTPLKENWMKIFTPIVEHLGLQIRFNLKSRNVEIRTCKETKDVSALTKAADFVKAFILGFQVEDALALIRLDDLFLESFEITDVKPLKGDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADVKVHILGSFQNIKMARTAICNLILGNPPSKVYGNIRAVASRSADRF
uniprot
proteins
function
FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA (PubMed:25851604). {ECO:0000269|PubMed:25851604, ECO:0000269|PubMed:34516797}.
uniprot
proteins
mass_dalton
27924
uniprot
proteins
protein_family
PNO1 family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15497447
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25851604
uniprot
proteins
pubmed
34516797
uniprot
proteins
sequence_length
252
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15497447, ECO:0000269|PubMed:34516797}.
uniprot
proteins