Dio1
entrez
25430
canonical
uniprot
P24389
canonical
ensembl
ENSRNOG00000061237
resolver
ensembl
ENSRNOG00055029863
resolver
ensembl
ENSRNOG00060026719
resolver
ensembl
ENSRNOG00065023419
resolver
ensp
ENSRNOP00000070330
resolver
ensp
ENSRNOP00055042685
resolver
ensp
ENSRNOP00060038481
resolver
ensp
ENSRNOP00065032554
resolver
enst
ENSRNOT00055051747
resolver
enst
ENSRNOT00060046314
resolver
enst
ENSRNOT00065040050
resolver
genesymbol
Dio1
resolver
genesymbol_syn
Itdi1
resolver
genesymbol_syn
Txdi1
resolver
uniprot_entry
IOD1_RAT
resolver
amino_acid_sequence
MGLSQLWLWLKRLVIFLQVALEVATGKVLMTLFPERVKQNILAMGQKTGMTRNPRFAPDNWVPTFFSIQYFWFVLKVRWQRLEDRAEYGGLAPNCTVVRLSGQKCNVWDFIQGSRPLVLNFGSCTUPSFLLKFDQFKRLVDDFASTADFLIIYIEEAHATDGWAFKNNVDIRQHRSLQDRLRAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRICYKGKPGPWNYNPEEVRAVLEKLCIPPGHMPQF
uniprot
proteins
ec_number
1.21.99.3
uniprot
proteins
ec_number
1.21.99.4
uniprot
proteins
function
FUNCTION: Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:1517238, PubMed:2040632, PubMed:7744884, PubMed:1825132). Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD) (By similarity). Catalyzes the deiodination of T4 to 3,3',5'-triiodothyronine (rT3), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine(3-T1) and 3,3'-diiodothyronine (3,3'-T2) to 3-T1 via inner-ring deiodination (IRD) (By similarity). Catalyzes the deiodination of rT3 to 3,3'-T2 via ORD (PubMed:1517238, PubMed:2040632, PubMed:7744884, PubMed:1825132, PubMed:8187873). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine, 3',5'-diiodothyronamine and 3,3'-diiodothyronamine as well as tyrosyl ring deiodinations of 3,5,3'-triiodothyronamine and 3,5-diiodothyronamine (By similarity). Catalyzes the deiodination of T3 and 3,3',5-triiodo-L-thyronine sulfate via IRD (PubMed:8187873). Catalyzes the deiodination of L-thyroxine sulfate via IRD and 3,3',5'-triiodo-L-thyronine sulfate via ORD (PubMed:4006868). {ECO:0000250|UniProtKB:P49895, ECO:0000250|UniProtKB:Q2QEI3, ECO:0000250|UniProtKB:Q61153, ECO:0000269|PubMed:1517238, ECO:0000269|PubMed:2040632, ECO:0000269|PubMed:4006868, ECO:0000269|PubMed:7744884, ECO:0000269|PubMed:8187873}.
uniprot
proteins
mass_dalton
29730
uniprot
proteins
mutagenesis
MUTAGEN 126; /note="U->C: Retains 10% of enzyme activity towards 3,3',5'-triiodothyronine."; /evidence="ECO:0000269|PubMed:1825132"; MUTAGEN 126; /note="U->L: Complete loss of enzyme activity towards 3,3',5'-triiodothyronine."; /evidence="ECO:0000269|PubMed:1825132"; MUTAGEN 158; /note="H->F,Q,N: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:1517238"; MUTAGEN 174; /note="H->N: 100-fold increase in KM for 3,3',5'-triiodo-L-thyronine."; /evidence="ECO:0000269|PubMed:1517238"; MUTAGEN 174; /note="H->Q: 20-fold increase in KM for 3,3',5'-triiodo-L-thyronine."; /evidence="ECO:0000269|PubMed:1517238"; MUTAGEN 185; /note="H->N: No effect on enzyme activity."; /evidence="ECO:0000269|PubMed:1517238
uniprot
proteins
protein_family
Iodothyronine deiodinase family
uniprot
proteins
pubmed
11089566
uniprot
proteins
pubmed
1517238
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1825132
uniprot
proteins
pubmed
2040632
uniprot
proteins
pubmed
4006868
uniprot
proteins
pubmed
7744884
uniprot
proteins
pubmed
8187873
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11089566}; Single-pass type III membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:7744884}; Single-pass type III membrane protein {ECO:0000305|PubMed:7744884}. Basolateral cell membrane {ECO:0000269|PubMed:2040632}; Single-pass type III membrane protein {ECO:0000305|PubMed:2040632}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins