ATPSCKMT
entrez
134145
canonical
uniprot
Q6P4H8
canonical
ensembl
ENSG00000150756
resolver
ensp
ENSP00000420876
resolver
ensp
ENSP00000422338
resolver
ensp
ENSP00000700380
resolver
genesymbol
ATPSCKMT
resolver
genesymbol_syn
FAM173B
resolver
hgnc
HGNC:27029
resolver
uniprot
B4DT41
resolver
uniprot
B4DXK2
resolver
uniprot
E9PBZ4
resolver
uniprot_entry
ACKMT_HUMAN
resolver
uniprot_sec
B4DT41
resolver
uniprot_sec
B4DXK2
resolver
uniprot_sec
E9PBZ4
resolver
amino_acid_sequence
MEGGGGIPLETLKEESQSRHVLPASFEVNSLQKSNWGFLLTGLVGGTLVAVYAVATPFVTPALRKVCLPFVPATTKQIENVVKMLRCRRGSLVDIGSGDGRIVIAAAKKGFTAVGYELNPWLVWYSRYRAWREGVHGSAKFYISDLWKVTFSQYSNVVIFGVPQMMLQLEKKLERELEDDARVIACRFPFPHWTPDHVTGEGIDTVWAYDASTFRGREKRPCTSMHFQLPIQA
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (PubMed:29444090, PubMed:30530489). Promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090). {ECO:0000269|PubMed:29444090, ECO:0000269|PubMed:30530489}.
uniprot
proteins
mass_dalton
26110
uniprot
proteins
mutagenesis
MUTAGEN 94; /note="D->A: Abolished protein-lysine N-methyltransferase activity and ability to promote chronic pain."; /evidence="ECO:0000269|PubMed:29444090"; MUTAGEN 117; /note="E->A: Abolished protein-lysine N-methyltransferase activity."; /evidence="ECO:0000269|PubMed:30530489
uniprot
proteins
protein_family
ANT/ATPSC lysine N-methyltransferase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
29444090
uniprot
proteins
pubmed
30530489
uniprot
proteins
sequence_length
233
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:30530489, ECO:0000305|PubMed:29444090}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to mitochondrial cristae. {ECO:0000269|PubMed:29444090}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins