Tmem266
entrez
244886
canonical
uniprot
Q8BZB3
canonical
ensembl
ENSMUSG00000032313
resolver
ensp
ENSMUSP00000034862
resolver
genesymbol
Tmem266
resolver
uniprot
B1B1B3
resolver
uniprot
Q6NVG3
resolver
uniprot_entry
TM266_MOUSE
resolver
uniprot_sec
B1B1B3
resolver
uniprot_sec
Q6NVG3
resolver
amino_acid_sequence
MALVTSFNMANPQPAIEGGISEVEIISQQVDEETKSIAPVQLVNFAYRDLPLAAVDLSTGGSQLLSNLDEEYQREGSDWLKPCCGKRAAVWQVFLLSASLNSFLVACVILVVILLTLELLIDTKLLQFSNAFQFAGVIHWISLVILSVFFSETVLRIVVLGIWDYIENKIEVFDGAVIILSLAPMVASTVANGPRSPWDAISLIIMFRIWRVKRVIDAYVLPVKLEMEMVTQQYEKAKAIQDEQLERLTQICQEQGFEIRQLRAHLAQQDLDLAAEREAALQAPHVLSQPRSRYKVVEAGTWAEETAAESIVEELRPSQEATVKDDMNSYISQYYNGPSSDSGAPEPAVCVVTTAAIDIHQPNVPSDLFSVDLPLKLSGNSTCASATSETTSHSTCGSVTRAQSASSQTLGSSTDCSTPREELLPSKPRSSPLPLLLPPQQLVAEATVQDLMSSLSKDPCPSHKALDPAPLAQPTPLGSVQTSPELEHRVSLFNQKNQEALPVLQINPVIHLQPTAGLEEKFRSLESKEPKLHTVPEA
uniprot
proteins
function
FUNCTION: Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition. {ECO:0000250|UniProtKB:Q2M3C6}.
uniprot
proteins
mass_dalton
58897
uniprot
proteins
mutagenesis
MUTAGEN 252; /note="C->A: Loss of homodimerization."; /evidence="ECO:0000269|PubMed:35574701
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25165868
uniprot
proteins
pubmed
35574701
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendrite {ECO:0000269|PubMed:25165868}. Perikaryon {ECO:0000250|UniProtKB:Q2M3C6}. Note=Present in the dendrites and soma of cerebellar granule neurons, but not in their axon. {ECO:0000250|UniProtKB:Q2M3C6}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:35574701}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:35574701}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 103..123; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 131..151; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 200..220; /note="Helical; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:Q2M3C6
uniprot
proteins