Intu
entrez
380614
canonical
uniprot
Q059U7
canonical
ensembl
ENSMUSG00000060798
resolver
ensp
ENSMUSP00000088725
resolver
ensp
ENSMUSP00000282684
resolver
genesymbol
Intu
resolver
genesymbol_syn
Kiaa1284
resolver
genesymbol_syn
Pdzd6
resolver
uniprot
Q80TG0
resolver
uniprot
Q8BS60
resolver
uniprot
Q8C9Y0
resolver
uniprot_entry
INTU_MOUSE
resolver
uniprot_sec
Q80TG0
resolver
uniprot_sec
Q8BS60
resolver
uniprot_sec
Q8C9Y0
resolver
amino_acid_sequence
MAGLARGDSRGRPPELPGDLSSQEEEEEEGDSDAGASSLGSYSSASSDTDVEPEWLDSVQKNGELFYLELSEDEEESLLPETQTANHVNHVRFSDKEVIIEEDDSRERKKSEPKLRRFTKILKSKSLLPRRHHKKSSSNNGPVSILKHQSSQKTGVTVQQRYKDVTVYINPRKLTAIKAREQVKLLEVLVGIIHQTKRSWKRSAKQADGERLVVHGLLPGGSAMKSGQVLVGDVLVAVNDVDVTSENIERVLSCIPGPMQVKLTFENAYAVKRETAQPQKKKAQSSTQDLVKLLCGSEADAVQHSTLSIPHISMYLTLQLQSEAAREEQEILYHYPVSEASQKLKSVRGIFLTLCDMLESVTGTQVTSSSLHLNGKQIHVAYLKESDKLLLIGLPAEEVPLPQLRNMIEDVAQTLKFMYGSLDSAFCQVENAPRLDHFFSLFFERALRPGKLHLSGSPSAQQYAAASAVLLDNLPGVRWLVLPQELKVELDTALSDLEAADFEELSEDYYDMRRLYTILGSSLFYKGYMVCSHLPKDDVIEIAAYCRQHCLLPLAAKQRIGQLIIWREVFPRHHLQPPSDSDPEAFQEPEGRYFLLVVGLRHYLLCVLLEAGGCASKATGNPGPDCIYVDQVRATLHQLEGVDSRIEEQLATSPGPCLSCADWFLAAPREKADSLTTSPILSRLQGPSKTAASPTCRRTFFSDYSFKARKPSPSRIGGGREPTEGEESAGLSPHATPDAVRKQRESEGSDDNVALLKLARKKSTLPNPFHLGTSKKELSEKELEVYDIMKLTSGPENTLFHYVALETVQGIFITPTHEEVAQLGGSVHSQLIKNFHQCCLSIRAFFQQTLKEEKKKALSDGEHSEPTNSVSSLSPVKEHGVLFECSPENWTDQKKTPPVMSYWVVGRLFLNPKPQELYVCFHDSVSEIAIEMAFKLFFGLTL
uniprot
proteins
function
FUNCTION: Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (PubMed:20067783, PubMed:21761479). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity). Required for recruitment of CPLANE2 to the mother centriole (PubMed:29038301). Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate (PubMed:35427153). {ECO:0000250|UniProtKB:Q9ULD6, ECO:0000269|PubMed:20067783, ECO:0000269|PubMed:21761479, ECO:0000269|PubMed:29038301, ECO:0000269|PubMed:35427153}.
uniprot
proteins
mass_dalton
104821
uniprot
proteins
protein_family
Inturned family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20067783
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21761479
uniprot
proteins
pubmed
27158779
uniprot
proteins
pubmed
29038301
uniprot
proteins
pubmed
35427153
uniprot
proteins
sequence_length
942
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20067783}. Cell surface {ECO:0000250|UniProtKB:Q2I0E5}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:29038301}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:29038301}. Note=Enriched at the apical surface in ciliated cells (By similarity). Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:29038301). Recruited to the centriole in a TTBK2-dependent manner (PubMed:29038301). {ECO:0000250|UniProtKB:Q2I0E5, ECO:0000269|PubMed:29038301}.
uniprot
proteins