Celf2
entrez
29428
canonical
uniprot
Q792H5
canonical
ensembl
ENSRNOG00000023661
resolver
ensp
ENSRNOP00000023436
resolver
ensp
ENSRNOP00000077512
resolver
ensp
ENSRNOP00000078975
resolver
ensp
ENSRNOP00000083368
resolver
ensp
ENSRNOP00000084295
resolver
ensp
ENSRNOP00000084524
resolver
ensp
ENSRNOP00000095071
resolver
ensp
ENSRNOP00000110458
resolver
enst
ENSRNOT00000023436
resolver
enst
ENSRNOT00000093949
resolver
enst
ENSRNOT00000095889
resolver
enst
ENSRNOT00000097332
resolver
enst
ENSRNOT00000101298
resolver
genesymbol
Celf2
resolver
genesymbol_syn
Cugbp2
resolver
genesymbol_syn
Etr3
resolver
genesymbol_syn
Napor
resolver
uniprot
A0A8I5ZWV8
resolver
uniprot
A0A8I5ZWW9
resolver
uniprot
A0A8I5ZYB3
resolver
uniprot
A0A8I6GLG1
resolver
uniprot
A1L1J5
resolver
uniprot
O88756
resolver
uniprot
Q78ZF0
resolver
uniprot
Z4YNP1
resolver
uniprot_entry
A0A8I5ZWV8_RAT
resolver
uniprot_entry
A0A8I5ZWW9_RAT
resolver
uniprot_entry
A0A8I5ZYB3_RAT
resolver
uniprot_entry
A0A8I6GLG1_RAT
resolver
uniprot_entry
CELF2_RAT
resolver
uniprot_entry
Z4YNP1_RAT
resolver
uniprot_sec
A1L1J5
resolver
uniprot_sec
O88756
resolver
uniprot_sec
Q78ZF0
resolver
amino_acid_sequence
MRCPKSAVTMRNEELLLSNGTANKMNGALDHSDQPDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQTMEGCSSPIVVKFADTQKDKEQRRLQQQLAQQMQQLNTATWGNLTGLGGLTPQYLALLQQATSSSNLGAFSGIQQMAGMNALQLQNLATLAAAAAAAQTSATSTNANPLSSTSSALGALTSPVAASTPNSTAGAAMNSLTSLGTLQGLAGATVGLNNINALAGMAALNGGLGATGLTNGTAGTMDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSKPY
uniprot
proteins
function
FUNCTION: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs (By similarity). Promotes inclusion of exon 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA (By similarity). Involved in the apoB RNA editing activity (By similarity). Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediately upstream of the edited cytidine (By similarity). Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (By similarity). {ECO:0000250|UniProtKB:O95319, ECO:0000250|UniProtKB:Q9Z0H4}.
uniprot
proteins
mass_dalton
54271
uniprot
proteins
protein_family
CELF/BRUNOL family
uniprot
proteins
pubmed
10524244
uniprot
proteins
pubmed
12022233
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
508
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95319}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z0H4}. Note=Accumulates in the cytoplasm after ionizing radiation. Colocalizes with APOBEC1 and A1CF. RNA-binding activity is detected in both nuclear and cytoplasmic compartments (By similarity). {ECO:0000250}.
uniprot
proteins