Kras
entrez
24525
canonical
uniprot
P08644
canonical
ensembl
ENSRNOG00000081425
resolver
ensembl
ENSRNOG00055009514
resolver
ensembl
ENSRNOG00060008032
resolver
ensembl
ENSRNOG00065005903
resolver
genesymbol
Kras
resolver
genesymbol_syn
Kras2
resolver
uniprot
A0JN17
resolver
uniprot
P46203
resolver
uniprot
P97914
resolver
uniprot_entry
A0JN17_RAT
resolver
uniprot_entry
RASK_RAT
resolver
uniprot_sec
P46203
resolver
uniprot_sec
P97914
resolver
activity_regulation
ACTIVITY REGULATION: Alternates between an inactive form bound to GDP and an active form bound to GTP (By similarity). Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP) (By similarity). Interaction with SOS1 promotes exchange of bound GDP to GTP (By similarity). {ECO:0000250|UniProtKB:P01116}.
uniprot
proteins
amino_acid_sequence
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQELARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCVIM
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:3110778). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1 (PubMed:29959233). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity). {ECO:0000250|UniProtKB:P01116, ECO:0000269|PubMed:29959233, ECO:0000269|PubMed:3110778}.
uniprot
proteins
mass_dalton
21656
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs). {ECO:0000250|UniProtKB:P01116}.; PTM: Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes. {ECO:0000250|UniProtKB:P01112}.; PTM: Palmitoylated at Lys-182, Lys-184 and Lys-185. Lysine-depalmitoylation by SIRT2 promotes its localization to endomembranes in endocytic pathways. {ECO:0000250|UniProtKB:P01116}.
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
12594205
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
19319189
uniprot
proteins
pubmed
29959233
uniprot
proteins
pubmed
3009041
uniprot
proteins
pubmed
3023884
uniprot
proteins
pubmed
3110778
uniprot
proteins
pubmed
8058308
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P01116}; Lipid-anchor {ECO:0000250|UniProtKB:P01116}; Cytoplasmic side {ECO:0000250|UniProtKB:P01116}. Endomembrane system {ECO:0000250|UniProtKB:P01116}. Cytoplasm {ECO:0000250|UniProtKB:P01116}.; SUBCELLULAR LOCATION: [Isoform 2B]: Cell membrane {ECO:0000250|UniProtKB:P01116}; Lipid-anchor {ECO:0000250|UniProtKB:P01116}.
uniprot
proteins