Dlx1
entrez
13390
canonical
uniprot
Q64317
canonical
ensembl
ENSMUSG00000041911
resolver
ensp
ENSMUSP00000042413
resolver
enst
ENSMUST00000037119
resolver
genesymbol
Dlx1
resolver
uniprot_entry
DLX1_MOUSE
resolver
amino_acid_sequence
MTMTTMPESLNSPVSGKAVFMEFGPPNQQMSPSPMSHGHYSMHCLHSAGHSQPDGAYSSASSFSRPLGYPYVNSVSSHASSPYISSVQSYPGSASLAQSRLEDPGADSEKSTVVEGGEVRFNGKGKKIRKPRTIYSSLQLQALNRRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLMKQGGAALEGSALANGRALSAGSPPVPPGWNPNSSSGKGSGSSAGSYVPSYTSWYPSAHQEAMQQPQLM
uniprot
proteins
function
FUNCTION: Plays a role as a transcriptional activator or repressor (PubMed:21875655). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (By similarity). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (PubMed:21875655). Likely to play a regulatory role in the development of the ventral forebrain (PubMed:1676488). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (PubMed:1676488). {ECO:0000250|UniProtKB:P56177, ECO:0000269|PubMed:1676488, ECO:0000269|PubMed:21875655}.
uniprot
proteins
mass_dalton
27309
uniprot
proteins
protein_family
Distal-less homeobox family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1676488
uniprot
proteins
pubmed
21875655
uniprot
proteins
pubmed
8812481
uniprot
proteins
sequence_length
255
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P56177}.
uniprot
proteins