Rtn4rl2
entrez
311169
canonical
uniprot
Q80WD1
canonical
ensembl
ENSRNOG00000021513
resolver
ensp
ENSRNOP00000095119
resolver
genesymbol
Rtn4rl2
resolver
genesymbol_syn
Ngrh1
resolver
uniprot_entry
R4RL2_RAT
resolver
amino_acid_sequence
MLPGLRRLLQGPASACLLLTLLALPPVTPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRSLRPGTFGPNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFHGLSRLTILYLFNNSLASLPGEALADLPALEFLRLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLRTLRDTDFQACPPPTPTRPGSRARGNSSSNHLYGVAEAGAPPADPSTLYRDLPAEDSRGRQGGDAPTEDDYWGGYGGEDQRGEQTCPGAACQAPADSRGPVLSAGLRTPLLCLLLLAPHHL
uniprot
proteins
function
FUNCTION: Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (PubMed:15673660). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system (By similarity). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (PubMed:26335717). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). {ECO:0000250|UniProtKB:Q7M6Z0, ECO:0000269|PubMed:15673660, ECO:0000269|PubMed:22325200, ECO:0000269|PubMed:26335717}.
uniprot
proteins
mass_dalton
46184
uniprot
proteins
post_translational_modification
PTM: Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; is released both as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein. {ECO:0000250|UniProtKB:Q86UN3}.; PTM: N-glycosylated (PubMed:19420245, PubMed:21308849). O-glycosylated (PubMed:19420245). Contains terminal sialic acid groups on its glycan chains (PubMed:19420245). {ECO:0000269|PubMed:19420245, ECO:0000269|PubMed:21308849}.
uniprot
proteins
protein_family
Nogo receptor family
uniprot
proteins
pubmed
12694398
uniprot
proteins
pubmed
15673660
uniprot
proteins
pubmed
19420245
uniprot
proteins
pubmed
21308849
uniprot
proteins
pubmed
22325200
uniprot
proteins
pubmed
26335717
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12694398, ECO:0000269|PubMed:15673660, ECO:0000269|PubMed:19420245}; Lipid-anchor, GPI-anchor {ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7M6Z0}. Perikaryon {ECO:0000269|PubMed:12694398, ECO:0000269|PubMed:15673660}. Cell projection, axon {ECO:0000269|PubMed:12694398, ECO:0000269|PubMed:15673660}. Membrane raft {ECO:0000269|PubMed:15673660}. Note=Localized to the surface of neurons, including axons (PubMed:12694398, PubMed:15673660). Detected close to synapses, but is excluded from synapses (By similarity). {ECO:0000250|UniProtKB:Q7M6Z0, ECO:0000269|PubMed:12694398, ECO:0000269|PubMed:15673660}.
uniprot
proteins