Arf6
entrez
79121
canonical
uniprot
P62332
canonical
ensembl
ENSRNOG00000070951
resolver
ensembl
ENSRNOG00055009192
resolver
ensembl
ENSRNOG00060005964
resolver
ensembl
ENSRNOG00065006677
resolver
ensp
ENSRNOP00000077772
resolver
ensp
ENSRNOP00000079011
resolver
ensp
ENSRNOP00000080368
resolver
ensp
ENSRNOP00000099185
resolver
ensp
ENSRNOP00000099834
resolver
ensp
ENSRNOP00055012473
resolver
ensp
ENSRNOP00055012477
resolver
ensp
ENSRNOP00055012484
resolver
ensp
ENSRNOP00060007395
resolver
ensp
ENSRNOP00060007406
resolver
ensp
ENSRNOP00060007407
resolver
ensp
ENSRNOP00065007560
resolver
ensp
ENSRNOP00065007566
resolver
ensp
ENSRNOP00065007574
resolver
enst
ENSRNOT00000097511
resolver
enst
ENSRNOT00000101767
resolver
enst
ENSRNOT00000115929
resolver
enst
ENSRNOT00000171436
resolver
enst
ENSRNOT00000173547
resolver
enst
ENSRNOT00055015558
resolver
enst
ENSRNOT00055015562
resolver
enst
ENSRNOT00055015568
resolver
enst
ENSRNOT00060009861
resolver
enst
ENSRNOT00060009873
resolver
enst
ENSRNOT00060009874
resolver
enst
ENSRNOT00065010330
resolver
enst
ENSRNOT00065010336
resolver
enst
ENSRNOT00065010346
resolver
genesymbol
Arf6
resolver
uniprot
P26438
resolver
uniprot
Q5BKA5
resolver
uniprot_entry
ARF6_RAT
resolver
uniprot_sec
P26438
resolver
uniprot_sec
Q5BKA5
resolver
activity_regulation
ACTIVITY REGULATION: Activation is generally mediated by guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by GTPases activating protein (GAP). Inactivated by ACAP1 and ACAP2 (By similarity). Activated by NGF via NTRK1 (PubMed:26446845). {ECO:0000250|UniProtKB:P62330, ECO:0000269|PubMed:26446845}.
uniprot
proteins
amino_acid_sequence
MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:26446845). Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:16672654). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1. Required for NTRK1 sorting to the recycling pathway from early endosomes (PubMed:26446845). {ECO:0000250|UniProtKB:P62331, ECO:0000269|PubMed:16672654, ECO:0000269|PubMed:26446845}.
uniprot
proteins
mass_dalton
20082
uniprot
proteins
post_translational_modification
PTM: GTP-bound form is myristoylated on Lys-3 by NMT1 and NMT2, allowing ARF6 to remain on membranes during the GTPase cycle, thereby promoting its activity. GDP-bound inactive form is demyristoylated on Lys-3 by SIRT2 at early endosomes or endocytic recycling compartment to allow its efficient activation by a guanine exchange factor (GEF) after GDP release. {ECO:0000250|UniProtKB:P62330}.
uniprot
proteins
protein_family
Arf family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10022920
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16672654
uniprot
proteins
pubmed
26446845
uniprot
proteins
pubmed
8813705
uniprot
proteins
sequence_length
175
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62330}. Cell membrane {ECO:0000250|UniProtKB:P62330}; Lipid-anchor {ECO:0000250|UniProtKB:P62330}. Endosome membrane {ECO:0000250|UniProtKB:P62330}; Lipid-anchor {ECO:0000250|UniProtKB:P62330}. Recycling endosome membrane {ECO:0000269|PubMed:26446845}; Lipid-anchor {ECO:0000250|UniProtKB:P62330}. Cell projection, filopodium membrane {ECO:0000250|UniProtKB:P62330}; Lipid-anchor {ECO:0000250|UniProtKB:P62330}. Cell projection, ruffle {ECO:0000250|UniProtKB:P62330}. Cleavage furrow {ECO:0000250|UniProtKB:P62330}. Midbody, Midbody ring {ECO:0000250|UniProtKB:P62330}. Early endosome membrane {ECO:0000250|UniProtKB:P62331}; Lipid-anchor {ECO:0000250|UniProtKB:P62331}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P62331}; Lipid-anchor {ECO:0000250|UniProtKB:P62331}. Note=Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In late stages of cytokinesis, concentrates at the midbody ring/Flemming body (By similarity). Recruitment to the midbody ring requires both activation by PSD/EFA6A and interaction with KIF23/MKLP1 (By similarity). After abscission of the intercellular bridge, incorporated into one of the daughter cells as a midbody remnant and localizes to punctate structures beneath the plasma membrane (By similarity). Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles (By similarity). Myristoylation is required for proper localization to membranes: myristoylation on Lys-3 allows ARF6 to remain on membranes during the GTPase cycle (By similarity). {ECO:0000250|UniProtKB:P62330, ECO:0000250|UniProtKB:P62331}.
uniprot
proteins