EVL
entrez
51466
canonical
uniprot
Q9UI08
canonical
ensembl
ENSG00000196405
resolver
ensp
ENSP00000376652
resolver
ensp
ENSP00000384720
resolver
ensp
ENSP00000437904
resolver
ensp
ENSP00000664238
resolver
genesymbol
EVL
resolver
genesymbol_syn
RNB6
resolver
hgnc
HGNC:20234
resolver
uniprot
A0A024R6K5
resolver
uniprot
A0A2D1PGY7
resolver
uniprot
A8K105
resolver
uniprot
B7Z3I5
resolver
uniprot
O95884
resolver
uniprot
Q7Z522
resolver
uniprot
Q8TBV1
resolver
uniprot
Q9UF25
resolver
uniprot
Q9UIC2
resolver
uniprot_entry
A0A024R6K5_HUMAN
resolver
uniprot_entry
A0A2D1PGY7_HUMAN
resolver
uniprot_entry
EVL_HUMAN
resolver
uniprot_sec
A8K105
resolver
uniprot_sec
B7Z3I5
resolver
uniprot_sec
O95884
resolver
uniprot_sec
Q7Z522
resolver
uniprot_sec
Q8TBV1
resolver
uniprot_sec
Q9UF25
resolver
uniprot_sec
Q9UIC2
resolver
amino_acid_sequence
MSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGGPSSQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAASAPVSCSGPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSMSGLAAAIAGAKLRRVQRPEDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKEDESQMEDPSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKSPEAKSPLQSQPHSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQELSGISTT
uniprot
proteins
function
FUNCTION: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.
uniprot
proteins
mass_dalton
44620
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA; phosphorylation abolishes binding to SH3 domains of ABL and SRC. {ECO:0000250}.
uniprot
proteins
protein_family
Ena/VASP family
uniprot
proteins
pubmed
10747096
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
10993894
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15469845
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18158903
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28882895
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P70429}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:P70429}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P70429}. Note=Targeted to the leading edge of lamellipodia and the distal tip of stress fibers through interaction with a number of proteins. In activated T-cells, localizes to the F-actin collar and the distal tip of microspikes. {ECO:0000250|UniProtKB:P70429}.
uniprot
proteins