DOK5
entrez
55816
canonical
uniprot
Q9P104
canonical
ensembl
ENSG00000101134
resolver
ensp
ENSP00000262593
resolver
ensp
ENSP00000379270
resolver
genesymbol
DOK5
resolver
genesymbol_syn
C20orf180
resolver
hgnc
HGNC:16173
resolver
uniprot
Q5T7Y0
resolver
uniprot
Q5TE53
resolver
uniprot
Q8TEW7
resolver
uniprot
Q96H13
resolver
uniprot
Q9BZ24
resolver
uniprot
Q9NQF4
resolver
uniprot
Q9Y411
resolver
uniprot_entry
DOK5_HUMAN
resolver
uniprot_sec
Q5T7Y0
resolver
uniprot_sec
Q5TE53
resolver
uniprot_sec
Q8TEW7
resolver
uniprot_sec
Q96H13
resolver
uniprot_sec
Q9BZ24
resolver
uniprot_sec
Q9NQF4
resolver
uniprot_sec
Q9Y411
resolver
amino_acid_sequence
MASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPAYRSEH
uniprot
proteins
function
FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
uniprot
proteins
mass_dalton
35464
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF. {ECO:0000269|PubMed:12730241}.
uniprot
proteins
protein_family
DOK family
uniprot
proteins
protein_family
Type B subfamily
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12454490
uniprot
proteins
pubmed
12595900
uniprot
proteins
pubmed
12730241
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
sequence_length
306
uniprot
proteins