Shkbp1
entrez
192192
canonical
uniprot
Q6P7W2
canonical
ensembl
ENSMUSG00000089832
resolver
ensp
ENSMUSP00000003857
resolver
ensp
ENSMUSP00000218007
resolver
ensp
ENSMUSP00000218008
resolver
ensp
ENSMUSP00000218011
resolver
genesymbol
Shkbp1
resolver
genesymbol_syn
Sb1
resolver
uniprot
Q3TUN8
resolver
uniprot
Q9ES31
resolver
uniprot_entry
SHKB1_MOUSE
resolver
uniprot_sec
Q3TUN8
resolver
uniprot_sec
Q9ES31
resolver
amino_acid_sequence
MAVATTAVEGVPSRGAPGEVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTLKDETGAIFIDRDPTVFAPILNFLRTKELDPRGVHGSSLLHEAQFYGLTPLVRRLQVREELDRSSCGNVLFNGYLPPPVFPVKRRNRHSLVGPQQIGGRPAPVRRSNTMPPNLGNAGLLGRMLDERAPPSPSGQPEEPGMVRLVCGHHNWIAVAYTHFLVCYRLKEASGWQLAFSSPRLDWPIERLALAARVLGGAPGEHDKMVAAATGSEILLWALQAQGGGSEIGVFHLGVPVEALFFVGNQLIATSHTGRIGVWNAVTKHWQVQEVQPITSYDAAGSFLLLGCSNGSIYYVDVQKFPLRMKDNDLLVSELYRDPAEDGVTALSVYLTPKTSDSGNWIEIAYGTSSGVVRVIVQHPETVGSGPQLFQTFSVHRSPVTKIMLSEKHLISVCADNNHVRTWSVTRFRGMISTQPGSTPLASFKILALESVDGLGGCSAGNDIGPYGERDDQQVFIQKVVPNASQLFVRLSSTGQRVCSVRSVDGSPTTAFTVLECEGSRRLGSRPRRYLLTGQANGSLAMWDLTTAMDGLGQTPAGGLTEEELMDQLEQCELSPLASSRGSFPSPSPRTSLTSLHSASSNTSLYGPRGSPSPPQAEARRRGAGSFVDRCQELARGAPELRWPPTPAPRPSTSLGNPLTALKKTLNETSF
uniprot
proteins
function
FUNCTION: Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation (PubMed:21830225). {ECO:0000269|PubMed:21830225}.
uniprot
proteins
mass_dalton
76103
uniprot
proteins
mutagenesis
MUTAGEN 623; /note="R->A: No loss of interaction with SH3KBP1, loss of translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation, strong delay in the degradation of EGFR upon EGF activation and enhancement of EGFR signaling induced serum response element (SRE) transcriptional reporter activity. Loss of interaction with SH3KBP1, no loss of translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation, no effect on the degradation of EGFR upon EGF activation and no effect on EGFR signaling induced serum response element (SRE) transcriptional reporter activity; when associated with A-683."; /evidence="ECO:0000269|PubMed:21830225"; MUTAGEN 683; /note="R->A: No loss of interaction with SH3KBP1, loss of translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation, slight delay in the degradation of EGFR upon EGF activation and enhancement of EGFR signaling induced serum response element (SRE) transcriptional reporter activity. Loss of interaction with SH3KBP1, no loss of translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation, no effect on the degradation of EGFR upon EGF activation and no effect on EGFR signaling induced serum response element (SRE) transcriptional reporter activity; when associated with A-623."; /evidence="ECO:0000269|PubMed:21830225
uniprot
proteins
protein_family
KCTD3 family
uniprot
proteins
pubmed
11152963
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21830225
uniprot
proteins
sequence_length
704
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q8TBC3}.
uniprot
proteins