RBBP7
entrez
5931
canonical
uniprot
Q16576
canonical
ensembl
ENSG00000102054
resolver
ensp
ENSP00000369424
resolver
ensp
ENSP00000369427
resolver
ensp
ENSP00000533807
resolver
genesymbol
RBBP7
resolver
genesymbol_syn
RBAP46
resolver
hgnc
HGNC:9890
resolver
uniprot
Q5JP00
resolver
uniprot
Q6FHQ0
resolver
uniprot_entry
Q6FHQ0_HUMAN
resolver
uniprot_entry
RBBP7_HUMAN
resolver
uniprot_sec
Q5JP00
resolver
amino_acid_sequence
MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDYALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSELEGQGS
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure, X-linked, 9 (SPGFX9) [MIM:301137]: A male infertility disorder characterized by spermatogenesis maturation arrest and non-obstructive azoospermia. {ECO:0000269|PubMed:35809576, ECO:0000269|PubMed:37843278}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}.
uniprot
proteins
mass_dalton
47820
uniprot
proteins
protein_family
WD repeat RBAP46/RBAP48/MSI1 family
uniprot
proteins
pubmed
10220405
uniprot
proteins
pubmed
10444591
uniprot
proteins
pubmed
10866654
uniprot
proteins
pubmed
11102443
uniprot
proteins
pubmed
11118440
uniprot
proteins
pubmed
11784859
uniprot
proteins
pubmed
12435631
uniprot
proteins
pubmed
12920132
uniprot
proteins
pubmed
14609955
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15310751
uniprot
proteins
pubmed
15456747
uniprot
proteins
pubmed
15701600
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16428440
uniprot
proteins
pubmed
18571423
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20523938
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25556658
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28977666
uniprot
proteins
pubmed
33283408
uniprot
proteins
pubmed
35809576
uniprot
proteins
pubmed
37843278
uniprot
proteins
pubmed
7503932
uniprot
proteins
pubmed
9150135
uniprot
proteins
pubmed
9427644
uniprot
proteins
pubmed
9651585
uniprot
proteins
pubmed
9790534
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}.
uniprot
proteins