Slc3a2
entrez
50567
canonical
uniprot
Q794F9
canonical
ensembl
ENSRNOG00000018487
resolver
ensp
ENSRNOP00000025196
resolver
enst
ENSRNOT00000025196
resolver
genesymbol
Slc3a2
resolver
uniprot
A0A0H2UHQ0
resolver
uniprot_entry
4F2_RAT
resolver
uniprot_entry
A0A0H2UHQ0_RAT
resolver
amino_acid_sequence
MSQDTEVDMKDVELNELEPEKQPMNAADGAAAGEKNGLVKIKVAEDEAEAGVKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPVQRWWHKGALYRIGDLQAFVGPEARGIAGLKNHLEYLSTLKVKGLVLGPIHKNQKDEVNETDLKQIDPDLGSQEDFKDLLQSAKKKSIHIILDLTPNYKGQNAWFLPPQADIVATKMKEALSSWLQDGVDGFQVRDVGKLANASLYLAEWQNITKNFSEDRLLIAGTASSDLQQIVNILESTSDLLLTSSYLSQPVFTGEHAELLVIKYLNATGSRWCSWSVSQAGLLTSFIPAQFLRLYQLLLFTLPGTPVFSYGDELGLQAVALPGQPMEAPFMLWNESSNSQTSSPVSLNMTVKGQNEDPGSLLTQFRRLSDLRGKERSLLHGDFDALSSSSGLFSYVRHWDQNERYLVVLNFQDVGLSARVGASNLPAGISLPASANLLLSTDSTRLSREEGTSLSLENLSLNPYEGLLLQFPFVA
uniprot
proteins
function
FUNCTION: Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heterodimers to the plasma membrane. Forms heterodimers with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10049700, PubMed:10391916, PubMed:12614332, PubMed:15980244, PubMed:23426681, PubMed:9480885, PubMed:9726963). Heterodimers function as amino acid exchangers, the specificity of the substrate depending on the SLC7A subunit (By similarity). Heterodimers formed by SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids. Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (By similarity). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocate neutral amino acids with broad specificity, thyroid hormones and L-DOPA. SLC3A2 is essential for the plasma membrane localization, stability, and transport activity of SLC7A5 and SLC7A8. When associated with LAPTM4B, the SLC3A2/SLC7A5 heterodimer is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (By similarity). {ECO:0000250|UniProtKB:P08195, ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10049700, ECO:0000269|PubMed:10391916, ECO:0000269|PubMed:12614332, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:23426681, ECO:0000269|PubMed:9480885, ECO:0000269|PubMed:9726963}.
uniprot
proteins
mass_dalton
58072
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-300 and on Ser-421 by ecto-protein kinases favors heterotypic cell-cell interactions. {ECO:0000250|UniProtKB:P08195}.; PTM: N-glycosylated; N-glycosylation is crucial for trafficking and stability of SLC3A2 to the plasma membrane. SLC3A2 surface retention and endocytosis are precisely balanced by N-glycosylation. {ECO:0000250|UniProtKB:P08195}.
uniprot
proteins
protein_family
SLC3A transporter family
uniprot
proteins
pubmed
10049700
uniprot
proteins
pubmed
10391916
uniprot
proteins
pubmed
11095508
uniprot
proteins
pubmed
12614332
uniprot
proteins
pubmed
15120633
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15980244
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23426681
uniprot
proteins
pubmed
9480885
uniprot
proteins
pubmed
9726963
uniprot
proteins
sequence_length
527
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P08195}. Cell membrane {ECO:0000269|PubMed:10391916, ECO:0000269|PubMed:11095508, ECO:0000269|PubMed:9480885}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P08195}. Cell junction {ECO:0000250|UniProtKB:P10852}. Lysosome membrane {ECO:0000250|UniProtKB:P08195}. Melanosome {ECO:0000250|UniProtKB:P08195}. Basolateral cell membrane {ECO:0000250|UniProtKB:P10852}. Note=Localized at the plasma membrane when associated with SLC7A5 or SLC7A8. Localized to the apical membrane of placental syncytiotrophoblastic cells. Recruited to lysosomes by LAPTM4B (By similarity). Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. {ECO:0000250|UniProtKB:P08195, ECO:0000250|UniProtKB:P10852, ECO:0000269|PubMed:11095508}.
uniprot
proteins
transmembrane_region
TRANSMEM 76..98; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins