TRIM52
entrez
84851
canonical
uniprot
Q96A61
canonical
ensembl
ENSG00000183718
resolver
ensp
ENSP00000483005
resolver
ensp
ENSP00000508553
resolver
ensp
ENSP00000509065
resolver
ensp
ENSP00000509327
resolver
ensp
ENSP00000509812
resolver
ensp
ENSP00000510569
resolver
enst
ENST00000503005
resolver
enst
ENST00000510796
resolver
enst
ENST00000685507
resolver
enst
ENST00000686030
resolver
enst
ENST00000688015
resolver
genesymbol
TRIM52
resolver
genesymbol_syn
RNF102
resolver
hgnc
HGNC:19024
resolver
uniprot
A0A8I5KQM7
resolver
uniprot
A0A8I5KRY2
resolver
uniprot
A0A8I5KW90
resolver
uniprot
A0A8I5KXQ2
resolver
uniprot
A0A8I5KYD8
resolver
uniprot
L0CQ38
resolver
uniprot
Q59G66
resolver
uniprot_entry
A0A8I5KQM7_HUMAN
resolver
uniprot_entry
A0A8I5KRY2_HUMAN
resolver
uniprot_entry
A0A8I5KW90_HUMAN
resolver
uniprot_entry
A0A8I5KXQ2_HUMAN
resolver
uniprot_entry
A0A8I5KYD8_HUMAN
resolver
uniprot_entry
TRI52_HUMAN
resolver
uniprot_sec
L0CQ38
resolver
uniprot_sec
Q59G66
resolver
amino_acid_sequence
MAGYATTPSPMQTLQEEAVCAICLDYFKDPVSISCGHNFCRGCVTQLWSKEDEEDQNEEEDEWEEEEDEEAVGAMDGWDGSIREVLYRGNADEELFQDQDDDELWLGDSGITNWDNVDYMWDEEEEEEEEDQDYYLGGLRPDLRIDVYREEEILEAYDEDEDEELYPDIHPPPSLPLPGQFTCPQCRKSFTRRSFRPNLQLANMVQIIRQMCPTPYRGNRSNDQGMCFKHQEALKLFCEVDKEAICVVCRESRSHKQHSVLPLEEVVQEYQEIKLETTLVGILQIEQESIHSKAYNQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase (PubMed:27667714). Positively regulates the NF-kappa-B signaling pathway (PubMed:27667714, PubMed:28073078). {ECO:0000269|PubMed:27667714, ECO:0000269|PubMed:28073078}.; FUNCTION: (Microbial infection) Exhibits antiviral activity against Japanese encephalitis virus (JEV). Ubiquitinates the viral non-structural protein 2 (NS2A) and targets it for proteasome-mediated degradation. {ECO:0000269|PubMed:27667714}.
uniprot
proteins
mass_dalton
34653
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated (PubMed:27667714). Polyubiquitinated (PubMed:20596523, PubMed:27667714). Undergoes extremely rapid proteolytic degradation by the proteasome (PubMed:31133683). {ECO:0000269|PubMed:20596523, ECO:0000269|PubMed:27667714, ECO:0000269|PubMed:31133683}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20596523
uniprot
proteins
pubmed
24158625
uniprot
proteins
pubmed
27667714
uniprot
proteins
pubmed
28073078
uniprot
proteins
pubmed
31133683
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28073078}. Cytoplasm, cytosol {ECO:0000269|PubMed:27667714}. Nucleus {ECO:0000269|PubMed:27667714, ECO:0000269|PubMed:28073078}.
uniprot
proteins