DNCL1
entrez
8655
canonical
uniprot
P63167
canonical
ensembl
ENSG00000088986
resolver
ensp
ENSP00000242577
resolver
ensp
ENSP00000376296
resolver
ensp
ENSP00000376297
resolver
ensp
ENSP00000446614
resolver
ensp
ENSP00000447907
resolver
ensp
ENSP00000536900
resolver
ensp
ENSP00000536901
resolver
ensp
ENSP00000536902
resolver
ensp
ENSP00000536903
resolver
ensp
ENSP00000536904
resolver
ensp
ENSP00000536905
resolver
ensp
ENSP00000536906
resolver
ensp
ENSP00000536907
resolver
ensp
ENSP00000603778
resolver
ensp
ENSP00000603779
resolver
ensp
ENSP00000603780
resolver
ensp
ENSP00000603783
resolver
ensp
ENSP00000627738
resolver
ensp
ENSP00000627739
resolver
ensp
ENSP00000627740
resolver
ensp
ENSP00000627741
resolver
enst
ENST00000242577
resolver
enst
ENST00000392508
resolver
enst
ENST00000392509
resolver
enst
ENST00000548342
resolver
enst
ENST00000549989
resolver
enst
ENST00000866841
resolver
enst
ENST00000866842
resolver
enst
ENST00000866843
resolver
enst
ENST00000866844
resolver
enst
ENST00000866845
resolver
enst
ENST00000866846
resolver
enst
ENST00000866847
resolver
enst
ENST00000866848
resolver
enst
ENST00000933719
resolver
enst
ENST00000933720
resolver
enst
ENST00000933721
resolver
enst
ENST00000933724
resolver
enst
ENST00000957679
resolver
enst
ENST00000957680
resolver
enst
ENST00000957681
resolver
enst
ENST00000957682
resolver
genesymbol
DNCL1
resolver
genesymbol
DYNLL1
resolver
genesymbol_syn
DLC1
resolver
genesymbol_syn
DNCL1
resolver
genesymbol_syn
DNCLC1
resolver
genesymbol_syn
DYNLL1
resolver
genesymbol_syn
HDLC1
resolver
hgnc
HGNC:15476
resolver
uniprot
Q15701
resolver
uniprot
Q6FGH9
resolver
uniprot_entry
DYL1_HUMAN
resolver
uniprot_entry
Q6FGH9_HUMAN
resolver
uniprot_sec
Q15701
resolver
amino_acid_sequence
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG
uniprot
proteins
function
FUNCTION: Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (By similarity). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). In addition to its role in cytoskeleton and transport, acts as a protein-protein adapter, which inhibits and/or sequesters target proteins (PubMed:10198631, PubMed:15193260, PubMed:15891768, PubMed:16684779, PubMed:30464262, PubMed:37696958). Involved in the response to DNA damage by acting as a key regulator of DNA end resection: when phosphorylated at Ser-88, recruited to DNA double-strand breaks (DSBs) by TP53BP1 and acts by disrupting MRE11 dimerization, thereby inhibiting DNA end resection (PubMed:30464262, PubMed:37696958). In a subset of DSBs, DYNLL1 remains unphosphorylated and promotes the recruitment of the Shieldin complex (PubMed:37696958). Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1 (By similarity). Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1 (PubMed:15891768, PubMed:16684779). Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules (PubMed:10198631, PubMed:15193260). Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (PubMed:10198631, PubMed:15193260). {ECO:0000250|UniProtKB:P61285, ECO:0000250|UniProtKB:P63170, ECO:0000250|UniProtKB:W7XJB1, ECO:0000269|PubMed:10198631, ECO:0000269|PubMed:15193260, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:30464262, ECO:0000269|PubMed:37696958}.
uniprot
proteins
mass_dalton
10366
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="T->A: Abolishes interaction with PAK1."; /evidence="ECO:0000269|PubMed:18650427"; MUTAGEN 88; /note="S->A: Abolishes growth factor-mediated phosphorylation. Increases BCL2L11 protein level and promotes apoptosis."; /evidence="ECO:0000269|PubMed:15193260, ECO:0000269|PubMed:18084006"; MUTAGEN 88; /note="S->E: Abolishes homodimerization. Abolishes interaction with BCL2L11 isoform 1 and isoform 2."; /evidence="ECO:0000269|PubMed:15193260, ECO:0000269|PubMed:18084006
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-88 promotes recruitment to DNA double-strand breaks (DSBs) by TP53BP1 and ability to inhibit MRE11 (PubMed:37696958). Phosphorylation at Ser-88 appears to control the dimer-monomer transition (PubMed:15193260, PubMed:18650427). According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro (PubMed:15193260, PubMed:18650427). {ECO:0000269|PubMed:15193260, ECO:0000269|PubMed:18650427, ECO:0000269|PubMed:37696958}.
uniprot
proteins
protein_family
Dynein light chain family
uniprot
proteins
pubmed
10198631
uniprot
proteins
pubmed
10426949
uniprot
proteins
pubmed
12857789
uniprot
proteins
pubmed
14607843
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
15193260
uniprot
proteins
pubmed
15891768
uniprot
proteins
pubmed
16684779
uniprot
proteins
pubmed
18084006
uniprot
proteins
pubmed
18650427
uniprot
proteins
pubmed
19380881
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20412299
uniprot
proteins
pubmed
20921139
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21402792
uniprot
proteins
pubmed
22167198
uniprot
proteins
pubmed
22965910
uniprot
proteins
pubmed
23482567
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24682284
uniprot
proteins
pubmed
25741013
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29955062
uniprot
proteins
pubmed
30464262
uniprot
proteins
pubmed
31505170
uniprot
proteins
pubmed
33323470
uniprot
proteins
pubmed
37696958
uniprot
proteins
pubmed
8628263
uniprot
proteins
sequence_length
89
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Chromosome {ECO:0000269|PubMed:37696958}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20921139}. Nucleus {ECO:0000269|PubMed:15891768}. Mitochondrion {ECO:0000269|PubMed:18084006}. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria (PubMed:18084006). Recruited to DNA double-strand breaks (DSBs) by TP53BP1 when phosphorylated at Ser-88 (PubMed:37696958). {ECO:0000269|PubMed:18084006, ECO:0000269|PubMed:37696958}.
uniprot
proteins