Bpnt1
entrez
64473
canonical
uniprot
Q9Z1N4
canonical
ensembl
ENSRNOG00000002378
resolver
ensp
ENSRNOP00000071594
resolver
ensp
ENSRNOP00000080410
resolver
enst
ENSRNOT00000088921
resolver
enst
ENSRNOT00000096481
resolver
genesymbol
Bpnt1
resolver
genesymbol_syn
Sal3
resolver
uniprot
A0A0G2K0V3
resolver
uniprot_entry
A0A0G2K0V3_RAT
resolver
uniprot_entry
BPNT1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Li(+) and Ca(2+), but not by Na(+). {ECO:0000269|PubMed:10347153}.
uniprot
proteins
amino_acid_sequence
MASSHNVLMRLVASAYSIAQKAGTIVRCVIAEGDLGIVQKTSATDLQTKADRMVQMSICSSLSRKFPKLTIIGEEDLPPGEVDQELIEDGQSEEILKQPCPSQYSAIKEEDLVVWVDPVDGTKEYTEGLLDNVTVLIGIAYEGKAIAGIINQPYYNYQAGPDAVLGRTIWGVLGLGAFGFQLKEAPAGKHIITTTRSHSNKLVTDCIAAMNPDNVLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILHAVGGKLTDIHGNPLQYDKEVKHMNSAGVLAALRNYEYYASRVPESVKSALIP
uniprot
proteins
ec_number
3.1.3.57
uniprot
proteins
ec_number
3.1.3.7
uniprot
proteins
function
FUNCTION: Phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Is also able to hydrolyze inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but is not active on AMP, 3'-AMP, fructose-1,6-bisphosphate, Ins(1)P, Ins(2)P and Ins(1,4,5)P3. Probably prevents the toxic accumulation of PAP, a compound which inhibits a variety of proteins, including PAPS-utilizing enzymes such as sulfotransferases, and RNA processing enzymes. Could also play a role in inositol recycling and phosphoinositide metabolism. {ECO:0000269|PubMed:10347153}.
uniprot
proteins
mass_dalton
33174
uniprot
proteins
protein_family
Inositol monophosphatase superfamily
uniprot
proteins
pubmed
10347153
uniprot
proteins
pubmed
11812139
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
308
uniprot
proteins