Pigv
entrez
366478
canonical
uniprot
Q5KR61
canonical
ensembl
ENSRNOG00000000121
resolver
ensp
ENSRNOP00000000133
resolver
ensp
ENSRNOP00000073811
resolver
enst
ENSRNOT00000000133
resolver
enst
ENSRNOT00000081841
resolver
genesymbol
Pigv
resolver
uniprot
A0A8L2R8F0
resolver
uniprot_entry
A0A8L2R8F0_RAT
resolver
uniprot_entry
PIGV_RAT
resolver
amino_acid_sequence
MGLLDPSQKEVLKFAVSCRILTLVLQALFNIIIPDHHADAFSPPRLAPSGSVDQLVEALLGGLSRWDAEHFLFIAEHGYLYEHNFAFFPGFPLALLMGTELLRPLQGLLSERSCLLVSVALLNSLFSVLAAVALHDLGCLVLHCPRQAFCAALLFCLSPANVFLAAGYSEALFAFLTFSAMGQLERGRGWASGLLFALAAGVRSNGLVSVGFLLHSQCRGFCSSLVVLDPLKGLVKLMASLCLSVLTVSLPFALFQYYAYTQFCFPGSAHAIPEPLLRLASDRGYRLAGDYEPPWCSRAPPLIYSYIQDVYWNVGLLRYYELRQVPNFLLATPVTVLVVWATWTYVTAHPWLCLTLGLQRTKDRESLEKPHPGFLSAKVFVYLVHAAALLAFGGLCMHVQVLTRLLGSSTPITYWFPAYLLQDREPLLRCVDTAPQKLLENSPPGQKAPRNCVMKLLYNWKTCSPVTKCILVYFLTYWLLGLIMHCNFLPWT
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
function
FUNCTION: Alpha-1,6-mannosyltransferase that catalyzes the transfer of the second mannose, via an alpha-1,6 bond, from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H2) intermediate to generate a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H3) and participates in the seventh step of the glycosylphosphatidylinositol-anchor biosynthesis (PubMed:15623507). May also transfer the second mannose on a 2-acyl-6-[2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H5), but less effectively (By similarity). {ECO:0000250|UniProtKB:A0A8C2M425, ECO:0000269|PubMed:15623507}.
uniprot
proteins
mass_dalton
54701
uniprot
proteins
pathway_participation
PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000269|PubMed:15623507}.
uniprot
proteins
post_translational_modification
PTM: Not N-glycosylated. {ECO:0000250|UniProtKB:Q9NUD9}.
uniprot
proteins
protein_family
PIGV family
uniprot
proteins
pubmed
15623507
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NUD9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NUD9}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..34; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 78..98; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 137..157; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 162..182; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 235..255; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 328..348; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 379..399; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 469..489; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins