Rgs7bp
entrez
294715
canonical
uniprot
Q5FVH8
canonical
ensembl
ENSRNOG00000013389
resolver
ensembl
ENSRNOG00055011479
resolver
ensembl
ENSRNOG00060003811
resolver
ensembl
ENSRNOG00065021835
resolver
ensp
ENSRNOP00000018058
resolver
ensp
ENSRNOP00055015720
resolver
ensp
ENSRNOP00060004769
resolver
ensp
ENSRNOP00065029946
resolver
enst
ENSRNOT00000018058
resolver
enst
ENSRNOT00055019499
resolver
enst
ENSRNOT00060006370
resolver
enst
ENSRNOT00065037137
resolver
genesymbol
Rgs7bp
resolver
genesymbol_syn
R7bp
resolver
uniprot_entry
R7BP_RAT
resolver
amino_acid_sequence
MSSAPNGRKKRPSRSTRSSIFQISKPPLQSGDWERRGSGSESAHKTQRALDDCKMLVQEFNTQVALYRELVISIGDVSVSCPSLRAEMHKTRTKGCEMARQAHQKLAAISGPEDGEIHPEICRLYIQLQCCLEMYTTEMLKSICLLGSLQFHRKGKEASGGAKSLDSKIEENAETPALEDSLSSPLDSQQQSWQVATDIENTERDMREMKNLLSKLRETMPLPLKNQDDSSLLNLTPYPMVRRRKRRFFGLCCLVSS
uniprot
proteins
function
FUNCTION: Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation. {ECO:0000250|UniProtKB:Q8BQP9}.
uniprot
proteins
mass_dalton
28966
uniprot
proteins
post_translational_modification
PTM: Palmitoylated (PubMed:21343290). Undergoes rapid palmitoylation turnover (PubMed:21343290). De novo and turnover palmitoylation are both mediated by ZDHHC2 (PubMed:21343290). Palmitoylation regulates the cell membrane and nuclear shuttling and the regulation of GPCR signaling (By similarity). Upon depalmitoylation, it is targeted from the plasma membrane into the nucleus (By similarity). GPCR signaling inhibits depalmitoylation and promotes localization to the plasma membrane (PubMed:21343290). {ECO:0000250|UniProtKB:Q8BQP9, ECO:0000269|PubMed:21343290}.
uniprot
proteins
protein_family
RGS7BP/RGS9BP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21343290
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21343290}. Cytoplasm {ECO:0000250|UniProtKB:Q8BQP9}. Cell membrane {ECO:0000269|PubMed:21343290}; Lipid-anchor {ECO:0000250|UniProtKB:Q8BQP9}. Note=Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation. {ECO:0000269|PubMed:21343290}.
uniprot
proteins