CCND3
entrez
896
canonical
uniprot
P30281
canonical
ensembl
ENSG00000112576
resolver
ensp
ENSP00000362078
resolver
ensp
ENSP00000362079
resolver
ensp
ENSP00000362082
resolver
ensp
ENSP00000397545
resolver
ensp
ENSP00000401595
resolver
ensp
ENSP00000426212
resolver
ensp
ENSP00000484424
resolver
ensp
ENSP00000662699
resolver
ensp
ENSP00000684503
resolver
ensp
ENSP00000789380
resolver
enst
ENST00000372987
resolver
genesymbol
CCND3
resolver
hgnc
HGNC:1585
resolver
uniprot
B2RD63
resolver
uniprot
B3KP19
resolver
uniprot
B3KQ22
resolver
uniprot
E9PAS4
resolver
uniprot
E9PB36
resolver
uniprot
Q5T8J0
resolver
uniprot
Q5T8J1
resolver
uniprot
Q6FG62
resolver
uniprot
Q96F49
resolver
uniprot_entry
B3KP19_HUMAN
resolver
uniprot_entry
CCND3_HUMAN
resolver
uniprot_entry
Q5T8J1_HUMAN
resolver
uniprot_sec
B2RD63
resolver
uniprot_sec
B3KQ22
resolver
uniprot_sec
E9PAS4
resolver
uniprot_sec
E9PB36
resolver
uniprot_sec
Q5T8J0
resolver
uniprot_sec
Q6FG62
resolver
uniprot_sec
Q96F49
resolver
amino_acid_sequence
MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
uniprot
proteins
function
FUNCTION: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:8114739). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:8114739). Hypophosphorylates RB1 in early G(1) phase (PubMed:8114739). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739). Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:16782892). Shows transcriptional coactivator activity with ATF5 independently of CDK4 (PubMed:15358120). {ECO:0000269|PubMed:15358120, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:8114739}.
uniprot
proteins
mass_dalton
32520
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-283 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex. {ECO:0000250|UniProtKB:P24385}.; PTM: Ubiquitinated by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation: ubiquitination is dependent on Thr-283 phosphorylation (PubMed:33854235, PubMed:33854239). The DCX(AMBRA1) complex represents the major regulator of CCND3 stability during the G1/S transition (PubMed:33854235, PubMed:33854239). Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation (PubMed:22020328). {ECO:0000269|PubMed:22020328, ECO:0000269|PubMed:33854235, ECO:0000269|PubMed:33854239}.
uniprot
proteins
protein_family
Cyclin D subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
12082095
uniprot
proteins
pubmed
1383201
uniprot
proteins
pubmed
1386335
uniprot
proteins
pubmed
1386336
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15327989
uniprot
proteins
pubmed
15358120
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16782892
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19237555
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
22020328
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
33854235
uniprot
proteins
pubmed
33854239
uniprot
proteins
pubmed
8114739
uniprot
proteins
pubmed
9106657
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15358120}. Cytoplasm {ECO:0000269|PubMed:15358120}.
uniprot
proteins