Slc43a2
entrez
215113
canonical
uniprot
Q8CGA3
canonical
ensembl
ENSMUSG00000038178
resolver
ensp
ENSMUSP00000046074
resolver
ensp
ENSMUSP00000104071
resolver
ensp
ENSMUSP00000126838
resolver
ensp
ENSMUSP00000301097
resolver
ensp
ENSMUSP00000301098
resolver
ensp
ENSMUSP00000301100
resolver
ensp
ENSMUSP00000301101
resolver
ensp
ENSMUSP00000301103
resolver
ensp
ENSMUSP00000301108
resolver
ensp
ENSMUSP00000301113
resolver
ensp
ENSMUSP00000301116
resolver
enst
ENSMUST00000042561
resolver
enst
ENSMUST00000108433
resolver
enst
ENSMUST00000169547
resolver
genesymbol
Slc43a2
resolver
genesymbol_syn
Lat4
resolver
uniprot
Q5CD76
resolver
uniprot_entry
LAT4_MOUSE
resolver
uniprot_sec
Q5CD76
resolver
activity_regulation
ACTIVITY REGULATION: Affinity and transport activity are regulated by a phosphorylation switch state at Ser-274 and Ser-297; increasing of affinity and amino acid transport activity via dephosphorylation at Ser-274 and phosphorylation at Ser-297. {ECO:0000250|UniProtKB:Q8N370}.
uniprot
proteins
amino_acid_sequence
MAPTLATAHRRRWWMACTAVLENLLFSAVLLGWGSLLIMLKSEGFYSYLCTKPENVTNSTVGGSAEPEPEELSLVNGWLSCKAQDEILNLAFTVGSFLLSAITLPLGIIMDKYGPRKLRLLGSACFAVSCLLIAYGASNPDSLSVLIFIALALNGFGGMCMTFTSLTLPNMFGDLRSTFIALMIGSYASSAVTFPGIKLIYDAGASFIGILVVWAGCSGLVFFNCFFNWPLEPFPGPEDMDYSVKIKFSWLGFDHKITGKQFYKQVTTVGRRLSVGSSMRTAKEQAALQEGHKLCLSTVDLEVKCQPDAAAAPSFMHSVFSPLLVLSLVTMCVTQLRLIFYMGAMNSILEFLVRGDQKTVALYTSIFGALQLLCLLTAPVIGYIMDWKLKECEDTSEEPEEKEGTQGEKKQKRDRQIQKVTNAMRAFAFTNVLLVGFGVTCLIPNLPLQIFSFVLHTIVRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLVSALFALLQQPLYLAMMGPLGGDPLWVNVGLLAMSMLGFCLPLYLICYRRQLERQLQQKREDSKLFLKINGSSNREAFV
uniprot
proteins
function
FUNCTION: Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine (PubMed:15659399, PubMed:25480797). Transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent (PubMed:25480797). Mediates the efflux of 3,3'-diiodo-L-thyronine (3,3'-T2) and 3-iodo-L-tyrosine (MIT) (By similarity). {ECO:0000250|UniProtKB:Q8N370, ECO:0000269|PubMed:15659399, ECO:0000269|PubMed:25480797}.
uniprot
proteins
mass_dalton
62430
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:15659399}.; PTM: Dephosphorylation at Ser-274 and phosphorylation at Ser-297 increase affinity and amino acid transport activity (PubMed:30379325). Phosphorylation-dephosphorylation cycle is regulated by food-entrained diurnal rhythm and dietary proteins (PubMed:32470053). {ECO:0000269|PubMed:30379325, ECO:0000269|PubMed:32470053}.
uniprot
proteins
protein_family
SLC43A transporter (TC 2.A.1.44) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15659399
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25480797
uniprot
proteins
pubmed
30379325
uniprot
proteins
pubmed
32470053
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15659399}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:25480797, ECO:0000269|PubMed:30379325}. Note=Located at the basolateral membrane in the small intestine enterocytes, kidney proximal tubule, thick ascending limb and, to a minor extent, of distal convoluted tubule epithelial cells. {ECO:0000269|PubMed:25480797, ECO:0000269|PubMed:30379325}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 319..341; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 365..385; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 434..454; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 461..481; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 489..509; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 515..535; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins