CBX6
entrez
23466
canonical
uniprot
O95503
canonical
ensembl
ENSG00000183741
resolver
ensp
ENSP00000216083
resolver
ensp
ENSP00000384490
resolver
enst
ENST00000216083
resolver
enst
ENST00000407418
resolver
genesymbol
CBX6
resolver
hgnc
HGNC:1556
resolver
uniprot
A8KAH0
resolver
uniprot
B0QXZ6
resolver
uniprot
Q96EM5
resolver
uniprot_entry
B0QXZ6_HUMAN
resolver
uniprot_entry
CBX6_HUMAN
resolver
uniprot_sec
A8KAH0
resolver
uniprot_sec
Q96EM5
resolver
amino_acid_sequence
MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAVHRLKKDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKRNRIILNLKVIDKGAGGGGAGQGAGALARPKVPSRNRVIGKSKKFSESVLRTQIRHMKFGAFALYKPPPAPLVAPSPGKAEASAPGPGLLLAAPAAPYDARSSGSSGCPSPTPQSSDPDDTPPKLLPETVSPSAPSWREPEVLDLSLPPESAATSKRAPPEVTAAAGPAPPTAPEPAGASSEPEAGDWRPEMSPCSNVVVTDVTSNLLTVTIKEFCNPEDFEKVAAGVAGAAGGGGSIGASK
uniprot
proteins
function
FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}.
uniprot
proteins
mass_dalton
43898
uniprot
proteins
mutagenesis
MUTAGEN 16; /note="I->F: Reduced interaction with H3C15 and H3C1."; /evidence="ECO:0000269|PubMed:18927235
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination regulates the function of the Polycomb group (PcG) multiprotein PRC1-like complex. Deubiquitinated by USP26. {ECO:0000269|PubMed:28839133}.
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18927235
uniprot
proteins
pubmed
21047797
uniprot
proteins
pubmed
21282530
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28839133
uniprot
proteins
sequence_length
412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18927235}. Chromosome {ECO:0000269|PubMed:18927235}. Note=Uniformely distributed in the nucleoplasm (PubMed:18927235). Localizes to the inactivated X chromosome in females (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235}.
uniprot
proteins