CCDC93
entrez
54520
canonical
uniprot
Q567U6
canonical
ensembl
ENSG00000125633
resolver
ensp
ENSP00000365477
resolver
ensp
ENSP00000554998
resolver
ensp
ENSP00000671372
resolver
enst
ENST00000376300
resolver
genesymbol
CCDC93
resolver
hgnc
HGNC:25611
resolver
uniprot
A8K3V7
resolver
uniprot
Q4LE78
resolver
uniprot
Q53TJ2
resolver
uniprot
Q8TBX5
resolver
uniprot
Q9H6R5
resolver
uniprot
Q9NV15
resolver
uniprot_entry
CCD93_HUMAN
resolver
uniprot_sec
A8K3V7
resolver
uniprot_sec
Q4LE78
resolver
uniprot_sec
Q53TJ2
resolver
uniprot_sec
Q8TBX5
resolver
uniprot_sec
Q9H6R5
resolver
uniprot_sec
Q9NV15
resolver
amino_acid_sequence
MGLPRGPEGQGLPEVETREDEEQNVKLTEILELLVAAGYFRARIKGLSPFDKVVGGMTWCITTCNFDVDVDLLFQENSTIGQKIALSEKIVSVLPRMKCPHQLEPHQIQGMDFIHIFPVVQWLVKRAIETKEEMGDYIRSYSVSQFQKTYSLPEDDDFIKRKEKAIKTVVDLSEVYKPRRKYKRHQGAEELLDEESRIHATLLEYGRRYGFSRQSKMEKAEDKKTALPAGLSATEKADAHEEDELRAAEEQRIQSLMTKMTAMANEESRLTASSVGQIVGLCSAEIKQIVSEYAEKQSELSAEESPEKLGTSQLHRRKVISLNKQIAQKTKHLEELRASHTSLQARYNEAKKTLTELKTYSEKLDKEQAALEKIESKADPSILQNLRALVAMNENLKSQEQEFKAHCREEMTRLQQEIENLKAERAPRGDEKTLSSGEPPGTLTSAMTHDEDLDRRYNMEKEKLYKIRLLQARRNREIAILHRKIDEVPSRAELIQYQKRFIELYRQISAVHKETKQFFTLYNTLDDKKVYLEKEISLLNSIHENFSQAMASPAARDQFLRQMEQIVEGIKQSRMKMEKKKQENKMRRDQLNDQYLELLEKQRLYFKTVKEFKEEGRKNEMLLSKVKAKAS
uniprot
proteins
function
FUNCTION: Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels (PubMed:37172566, PubMed:38459129). The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:25355947, PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C (PubMed:25355947). {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129}.; FUNCTION: (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface. {ECO:0000269|PubMed:28892079}.
uniprot
proteins
mass_dalton
73198
uniprot
proteins
mutagenesis
MUTAGEN 406; /note="H->R: Impairs interaction with DENND10."; /evidence="ECO:0000269|PubMed:37172566"; MUTAGEN 410; /note="E->K: Impairs interaction with DENND10."; /evidence="ECO:0000269|PubMed:37172566
uniprot
proteins
protein_family
CCDC93 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25355947
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28892079
uniprot
proteins
pubmed
37172566
uniprot
proteins
pubmed
38459129
uniprot
proteins
pubmed
38504028
uniprot
proteins
sequence_length
631
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000305|PubMed:25355947}.
uniprot
proteins