Rybp
entrez
56353
canonical
uniprot
Q8CCI5
canonical
ensembl
ENSMUSG00000072872
resolver
ensp
ENSMUSP00000098677
resolver
enst
ENSMUST00000101118
resolver
genesymbol
Rybp
resolver
genesymbol_syn
Dedaf
resolver
uniprot
B2RRB6
resolver
uniprot
Q9WVK2
resolver
uniprot_entry
RYBP_MOUSE
resolver
uniprot_sec
B2RRB6
resolver
uniprot_sec
Q9WVK2
resolver
amino_acid_sequence
MTMGDKKSPTRPKRQAKPAADEGFWDCSVCTFRNSAEAFKCSICDVRKGTSTRKPRINSQLVAQQVAQQYATPPPPKKEKKEKVEKPDKEKPEKDKDISPSVTKKNTNKKTKPKSDILKDPPSEANSIQSANATTKTSETNHTSRPRLKNVDRSTAQQLAVTVGNVTVIITDFKEKTRSSSTSSSTVTSSAGSEQQNQSSSGSESTDKGSSRSSTPKGDMSAVNDESF
uniprot
proteins
function
FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:22325148, PubMed:28596365). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365). May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (PubMed:22325148, PubMed:28596365). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (By similarity). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:17874297). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (By similarity). May bind to DNA (PubMed:19170609). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). {ECO:0000250|UniProtKB:Q8N488, ECO:0000269|PubMed:17874297, ECO:0000269|PubMed:19170609, ECO:0000269|PubMed:22325148, ECO:0000269|PubMed:27748911, ECO:0000269|PubMed:28596365}.
uniprot
proteins
mass_dalton
24777
uniprot
proteins
mutagenesis
MUTAGEN 31..32; /note="TF->AA: Loss of ubiquitin binding."; /evidence="ECO:0000269|PubMed:17070805
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated.
uniprot
proteins
pubmed
10369680
uniprot
proteins
pubmed
14765135
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16055728
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17070805
uniprot
proteins
pubmed
17874297
uniprot
proteins
pubmed
19170609
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22226355
uniprot
proteins
pubmed
22325148
uniprot
proteins
pubmed
27748911
uniprot
proteins
pubmed
28596365
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17070805}. Cytoplasm {ECO:0000250|UniProtKB:Q8N488}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17070805}. Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies. {ECO:0000269|PubMed:17070805}.
uniprot
proteins