CXCL8
entrez
3576
canonical
uniprot
P10145
canonical
ensembl
ENSG00000169429
resolver
ensp
ENSP00000306512
resolver
ensp
ENSP00000385908
resolver
enst
ENST00000307407
resolver
enst
ENST00000401931
resolver
genesymbol
CXCL8
resolver
genesymbol_syn
IL8
resolver
hgnc
HGNC:6025
resolver
uniprot
B2R4L8
resolver
uniprot
C9J4T6
resolver
uniprot
Q6FGF6
resolver
uniprot
Q6LAE6
resolver
uniprot
Q96RG6
resolver
uniprot
Q9C077
resolver
uniprot
Q9UCE1
resolver
uniprot
Q9UCR8
resolver
uniprot
Q9UCR9
resolver
uniprot
Q9UCS0
resolver
uniprot_entry
C9J4T6_HUMAN
resolver
uniprot_entry
IL8_HUMAN
resolver
uniprot_sec
B2R4L8
resolver
uniprot_sec
Q6FGF6
resolver
uniprot_sec
Q6LAE6
resolver
uniprot_sec
Q96RG6
resolver
uniprot_sec
Q9C077
resolver
uniprot_sec
Q9UCE1
resolver
uniprot_sec
Q9UCR8
resolver
uniprot_sec
Q9UCR9
resolver
uniprot_sec
Q9UCS0
resolver
amino_acid_sequence
MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS
uniprot
proteins
function
FUNCTION: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection (PubMed:18692776, PubMed:7636208). Also plays an important role in neutrophil activation (PubMed:2145175, PubMed:9623510). Released in response to an inflammatory stimulus, exerts its effect by binding to the G protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells (PubMed:1840701, PubMed:1891716). G protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways (PubMed:11971003, PubMed:8662698). {ECO:0000269|PubMed:11971003, ECO:0000269|PubMed:11978786, ECO:0000269|PubMed:1840701, ECO:0000269|PubMed:18692776, ECO:0000269|PubMed:1891716, ECO:0000269|PubMed:2145175, ECO:0000269|PubMed:2212672, ECO:0000269|PubMed:7636208, ECO:0000269|PubMed:8662698, ECO:0000269|PubMed:9623510}.
uniprot
proteins
mass_dalton
11098
uniprot
proteins
mutagenesis
MUTAGEN 91; /note="K->A: Decreases heparin-binding activity. Impairs heparin-binding activity and leukocyte transendothelial migration; when associated with A-94 and A-95."; /evidence="ECO:0000269|PubMed:24501198"; MUTAGEN 94; /note="K->A: Impairs heparin-binding activity and leukocyte transendothelial migration; when associated with A-91 and A-95."; /evidence="ECO:0000269|PubMed:24501198"; MUTAGEN 95; /note="R->A: Impairs heparin-binding activity and leukocyte transendothelial migration; when associated with A-91 and A-94."; /evidence="ECO:0000269|PubMed:24501198
uniprot
proteins
post_translational_modification
PTM: Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form. {ECO:0000269|PubMed:11023497, ECO:0000269|PubMed:11978786, ECO:0000269|PubMed:2145175, ECO:0000269|PubMed:2212672, ECO:0000269|PubMed:2523801, ECO:0000269|PubMed:2648135}.; PTM: Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation. {ECO:0000269|PubMed:18710930, ECO:0000269|PubMed:19608678}.; PTM: (Microbial infection) Cleaved by group A Streptococcus protease SpyCEP; leading to impaired neutrophil endothelial transmigration and thus increased virulence. {ECO:0000269|PubMed:18692776}.
uniprot
proteins
protein_family
Intercrine alpha (chemokine CxC) family
uniprot
proteins
pubmed
10368283
uniprot
proteins
pubmed
10707023
uniprot
proteins
pubmed
11023497
uniprot
proteins
pubmed
11971003
uniprot
proteins
pubmed
11978786
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14711052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1639201
uniprot
proteins
pubmed
1755384
uniprot
proteins
pubmed
1840701
uniprot
proteins
pubmed
18692776
uniprot
proteins
pubmed
18710930
uniprot
proteins
pubmed
1891716
uniprot
proteins
pubmed
19608678
uniprot
proteins
pubmed
1988949
uniprot
proteins
pubmed
2005614
uniprot
proteins
pubmed
2007144
uniprot
proteins
pubmed
20829347
uniprot
proteins
pubmed
2145175
uniprot
proteins
pubmed
2182630
uniprot
proteins
pubmed
2184886
uniprot
proteins
pubmed
2200751
uniprot
proteins
pubmed
2212672
uniprot
proteins
pubmed
24501198
uniprot
proteins
pubmed
2523801
uniprot
proteins
pubmed
2648135
uniprot
proteins
pubmed
2655583
uniprot
proteins
pubmed
2659722
uniprot
proteins
pubmed
2663993
uniprot
proteins
pubmed
2664463
uniprot
proteins
pubmed
2681204
uniprot
proteins
pubmed
2953813
uniprot
proteins
pubmed
31235521
uniprot
proteins
pubmed
3260265
uniprot
proteins
pubmed
3279957
uniprot
proteins
pubmed
3322281
uniprot
proteins
pubmed
3480540
uniprot
proteins
pubmed
7636208
uniprot
proteins
pubmed
8344717
uniprot
proteins
pubmed
8631339
uniprot
proteins
pubmed
8662698
uniprot
proteins
pubmed
9623510
uniprot
proteins
sequence_length
99
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins