Thoc5
entrez
360972
canonical
uniprot
Q68FX7
canonical
ensembl
ENSRNOG00000008456
resolver
ensp
ENSRNOP00000011281
resolver
ensp
ENSRNOP00000077470
resolver
ensp
ENSRNOP00000087796
resolver
ensp
ENSRNOP00000103476
resolver
enst
ENSRNOT00000011281
resolver
enst
ENSRNOT00000160359
resolver
genesymbol
Thoc5
resolver
genesymbol_syn
Fmip
resolver
uniprot
A0A8L2Q5G3
resolver
uniprot
A0ABK0L341
resolver
uniprot_entry
A0A8L2Q5G3_RAT
resolver
uniprot_entry
A0ABK0L341_RAT
resolver
uniprot_entry
THOC5_RAT
resolver
amino_acid_sequence
MSSESSKKRKPKVIRSDGTPTEGKRNRSDTEQEGRYYSEEAEVDLRDPGRDYELYKYTCQELQRLMAEIQDLKSKGSKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYSEAPPNISKAEITMGDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTRRRPTLGVQLDDKRKEMLKRHPLSVLLDLKCKDNSVLHLTFFYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLRDYVLELGHPYLWVQKLGGLHFPKEQPQHTVMADHSQSASHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSECQYLFPAKVVSRLVKWMIMAHEDYMELHFTKDIVEAGLAGDTNLYYLALIERGTAKLQAAVVLNPGYSSIPPVFRLCLNWKGEKTNSNDDNIRAMESEVNVCYRELCGPRPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSHR
uniprot
proteins
function
FUNCTION: Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes. {ECO:0000250|UniProtKB:Q13769}.; FUNCTION: Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development (By similarity). {ECO:0000250|UniProtKB:Q8BKT7}.
uniprot
proteins
mass_dalton
78660
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine upon binding to activated CSF1R; which causes a dissociation of the two proteins. Phosphorylation on Ser-5 and/or Ser-6 is required for nuclear export. Phosphorylated on Thr-327 in insulin-stimulated adipocytes (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
THOC5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
682
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13769}. Cytoplasm {ECO:0000250|UniProtKB:Q13769}. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250|UniProtKB:Q13769}.
uniprot
proteins