DHX8
entrez
1659
canonical
uniprot
Q14562
canonical
ensembl
ENSG00000067596
resolver
ensp
ENSP00000262415
resolver
ensp
ENSP00000437886
resolver
ensp
ENSP00000466900
resolver
ensp
ENSP00000496923
resolver
ensp
ENSP00000542104
resolver
ensp
ENSP00000747752
resolver
ensp
ENSP00000798499
resolver
enst
ENST00000262415
resolver
enst
ENST00000540306
resolver
enst
ENST00000589898
resolver
enst
ENST00000650571
resolver
genesymbol
DHX8
resolver
genesymbol_syn
DDX8
resolver
hgnc
HGNC:2749
resolver
uniprot
B7Z8F4
resolver
uniprot
F5H658
resolver
uniprot
K7END7
resolver
uniprot
Q05CV4
resolver
uniprot
Q86YB2
resolver
uniprot_entry
B7Z8F4_HUMAN
resolver
uniprot_entry
DHX8_HUMAN
resolver
uniprot_entry
F5H658_HUMAN
resolver
uniprot_entry
K7END7_HUMAN
resolver
uniprot_entry
Q05CV4_HUMAN
resolver
uniprot_entry
Q86YB2_HUMAN
resolver
amino_acid_sequence
MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSRDRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKYGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEPLYNRYEEPNAWRISRAFRRR
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}.
uniprot
proteins
mass_dalton
139315
uniprot
proteins
mutagenesis
MUTAGEN 594; /note="K->E: In GET; inhibition of pre-mRNA splicing and nuclear export of unspliced RNA."; /evidence="ECO:0000269|PubMed:8608946"; MUTAGEN 717; /note="S->L: In LAT; inhibition of pre-mRNA splicing and nuclear export of unspliced RNA."; /evidence="ECO:0000269|PubMed:8608946
uniprot
proteins
protein_family
DDX8/PRP22 sub-subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
protein_family
DEAH subfamily
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
16820410
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23096351
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28062851
uniprot
proteins
pubmed
28076346
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28502770
uniprot
proteins
pubmed
31256877
uniprot
proteins
pubmed
7935475
uniprot
proteins
pubmed
8608946
uniprot
proteins
sequence_length
1220
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28062851, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.
uniprot
proteins