S100P
entrez
6286
canonical
uniprot
P25815
canonical
ensembl
ENSG00000163993
resolver
ensp
ENSP00000296370
resolver
enst
ENST00000296370
resolver
genesymbol
S100P
resolver
genesymbol_syn
S100E
resolver
hgnc
HGNC:10504
resolver
uniprot
Q5J7W2
resolver
uniprot_entry
S100P_HUMAN
resolver
uniprot_sec
Q5J7W2
resolver
amino_acid_sequence
MTELETAMGMIIDVFSRYSGSEGSTQTLTKGELKVLMEKELPGFLQSGKDKDAVDKLLKDLDANGDAQVDFSEFIVFVAAITSACHKYFEKAGLK
uniprot
proteins
function
FUNCTION: May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). {ECO:0000269|PubMed:14617629, ECO:0000269|PubMed:19111582, ECO:0000269|PubMed:22399290}.
uniprot
proteins
mass_dalton
10400
uniprot
proteins
mutagenesis
MUTAGEN 21..23; /note="Missing: In S100Ppa; permanently active, interacts with EZR and PPP5C in absence of calcium; when associated with C-64, K-68 and S-73."; /evidence="ECO:0000269|PubMed:19111582, ECO:0000269|PubMed:22399290"; MUTAGEN 64; /note="N->C: In S100Ppa; permanently active, interacts with EZR and PPP5C in absence of calcium; when associated with 21-S--G-23, K-68 and S-73."; /evidence="ECO:0000269|PubMed:19111582, ECO:0000269|PubMed:22399290"; MUTAGEN 68; /note="Q->K: In S100Ppa; permanently active, interacts with EZR and PPP5C in absence of calcium; when associated with 21-S--G-23, C-64 and S-73."; /evidence="ECO:0000269|PubMed:19111582, ECO:0000269|PubMed:22399290"; MUTAGEN 73; /note="E->S: In S100Ppa; permanently active, interacts with EZR and PPP5C in absence of calcium; when associated with 21-S--G-23, C-64 and K-68."; /evidence="ECO:0000269|PubMed:19111582, ECO:0000269|PubMed:22399290
uniprot
proteins
protein_family
S-100 family
uniprot
proteins
pubmed
12507480
uniprot
proteins
pubmed
12808036
uniprot
proteins
pubmed
14617629
uniprot
proteins
pubmed
14672411
uniprot
proteins
pubmed
15171681
uniprot
proteins
pubmed
15213440
uniprot
proteins
pubmed
1540168
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15632002
uniprot
proteins
pubmed
1633809
uniprot
proteins
pubmed
19111582
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22399290
uniprot
proteins
pubmed
22431641
uniprot
proteins
sequence_length
95
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cell projection, microvillus membrane. Note=Colocalizes with S100PBP in the nucleus. Colocalizes with EZR in the microvilli in a calcium-dependent manner.
uniprot
proteins