Pde6h
entrez
114248
canonical
uniprot
P61250
canonical
ensembl
ENSRNOG00000005947
resolver
ensembl
ENSRNOG00055025860
resolver
ensembl
ENSRNOG00060009170
resolver
ensembl
ENSRNOG00065011843
resolver
ensp
ENSRNOP00000007905
resolver
ensp
ENSRNOP00055036517
resolver
ensp
ENSRNOP00060012043
resolver
ensp
ENSRNOP00065014708
resolver
enst
ENSRNOT00000007905
resolver
enst
ENSRNOT00055044612
resolver
enst
ENSRNOT00060015441
resolver
enst
ENSRNOT00065019235
resolver
genesymbol
Pde6h
resolver
uniprot
Q9D1Y6
resolver
uniprot
Q9EP63
resolver
uniprot_entry
CNCG_RAT
resolver
uniprot_sec
Q9D1Y6
resolver
uniprot_sec
Q9EP63
resolver
amino_acid_sequence
MSDSPCLSPPAPSQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIPGMEGLGTDITVICPWEAFSHLELHELAQFGII
uniprot
proteins
function
FUNCTION: Inhibitory gamma subunit of the cone-specific cGMP phosphodiesterase (PDE6) complex which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade (By similarity). The PDE6 holoenzyme consists of two catalytic alpha subunits (PDE6C) and two inhibitory gamma subunits (PDE6H) (By similarity). Light-activated GNAT2 relieves gamma subunit-mediated inhibition, allowing the catalytic subunits to hydrolyze cGMP and mediate visual signal transduction and amplification. The resulting decrease in cytosolic cGMP levels triggers the closure of cGMP-gated cation channels at the plasma membrane, leading to hyperpolarization of cone photoreceptors (By similarity). Inhibition by the gamma subunit is relatively dynamic and less tightly coupled than in rods, allowing transient access to the catalytic pocket and facilitating the rapid phototransduction kinetics characteristic of cones (By similarity). {ECO:0000250|UniProtKB:P22571, ECO:0000250|UniProtKB:P51160, ECO:0000250|UniProtKB:P61249}.
uniprot
proteins
mass_dalton
9044
uniprot
proteins
protein_family
Rod/cone cGMP-PDE gamma subunit family
uniprot
proteins
sequence_length
83
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P61249}. Note=Localized in cone outer segment disk membranes. {ECO:0000250|UniProtKB:P61249}.
uniprot
proteins