PTPRA
entrez
5786
canonical
uniprot
P18433
canonical
ensembl
ENSG00000132670
resolver
ensp
ENSP00000216877
resolver
ensp
ENSP00000314568
resolver
ensp
ENSP00000382787
resolver
ensp
ENSP00000546962
resolver
ensp
ENSP00000546964
resolver
ensp
ENSP00000546966
resolver
ensp
ENSP00000546967
resolver
ensp
ENSP00000546968
resolver
ensp
ENSP00000546971
resolver
ensp
ENSP00000546974
resolver
ensp
ENSP00000546980
resolver
ensp
ENSP00000546986
resolver
ensp
ENSP00000581932
resolver
ensp
ENSP00000640334
resolver
genesymbol
PTPRA
resolver
genesymbol_syn
PTPA
resolver
genesymbol_syn
PTPRL2
resolver
hgnc
HGNC:9664
resolver
uniprot
A0A1S5UZ22
resolver
uniprot
A8K2G8
resolver
uniprot
B7Z2A4
resolver
uniprot
D3DVX5
resolver
uniprot
E7ET72
resolver
uniprot
Q14513
resolver
uniprot
Q7Z2I2
resolver
uniprot
Q96TD9
resolver
uniprot_entry
A0A1S5UZ22_HUMAN
resolver
uniprot_entry
B7Z2A4_HUMAN
resolver
uniprot_entry
PTPRA_HUMAN
resolver
uniprot_sec
A8K2G8
resolver
uniprot_sec
D3DVX5
resolver
uniprot_sec
E7ET72
resolver
uniprot_sec
Q14513
resolver
uniprot_sec
Q7Z2I2
resolver
uniprot_sec
Q96TD9
resolver
amino_acid_sequence
MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity). {ECO:0000250|UniProtKB:P18052}.
uniprot
proteins
mass_dalton
90719
uniprot
proteins
mutagenesis
MUTAGEN 798; /note="Y->F: Abolishes integrin-mediated interaction with BCAR1 and BCAR3 and reduces interaction between BCAR1 and CRK and, BCAR1 and SRC. Abolishes integrin-induced SRC-mediated tyrosine phosphorylation of BCAR1. Abolishes integrin-mediated recruitment of BCAR1, BCAR3, CRK and PTPRA to focal adhesions. Reduces integrin-mediated activation and membrane recruitment of RAC1 and CDC42."; /evidence="ECO:0000269|PubMed:22801373
uniprot
proteins
post_translational_modification
PTM: Integrin binding to extracellular matrix induces phosphorylation at Tyr-798 which induces PTPRA localization and recruitment of BCAR3, BCAR1 and CRK to focal adhesions. {ECO:0000269|PubMed:22801373}.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 4 subfamily
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
2169617
uniprot
proteins
pubmed
2170109
uniprot
proteins
pubmed
2172030
uniprot
proteins
pubmed
2175890
uniprot
proteins
pubmed
22801373
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
802
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P18052}. Note=Localizes to focal adhesion sites following integrin engagement. {ECO:0000250|UniProtKB:P18052}.
uniprot
proteins
transmembrane_region
TRANSMEM 152..174; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins