Pde12
entrez
306231
canonical
uniprot
Q6AXQ5
canonical
ensembl
ENSRNOG00000059442
resolver
ensp
ENSRNOP00000073047
resolver
genesymbol
Pde12
resolver
uniprot_entry
PDE12_RAT
resolver
amino_acid_sequence
MWRLPGRAALRGVRSVVEQRSPAEATTHEAVRAMERAVVRCVPSEPKLSLSFALADGSHKNMQRDQSEPLGRALSRIATNALKGHAKVAAAKKSRKNRAHSSGGAACAATGSEPAATCEPVVKLYYREEAVAEDVLNVDAWQDGAVLQIGDVKYKVERNPPAFTELQLPRYIMAGFPVCPKLGLEFGDPASSVFRWYKEVKPGAAEPGDSGLASSSHSLQSSAWIETGVDERVYTPCNADIGLRLKLHCTPGNGQRFGPSRELESVCPVEAGPGTCTFDHRHLYTKKVTEDSFIRTVSYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADLICLQEVDRAVFSDSLVPALEAFGLEGVFRIKQHEGLATFYRKSKFRLLSQHDISFQEALKSDPLHKELLEKLALNPLAQEKVLQRSSVLQISVLQSTTDSSKKICVANTHLYWHPKGGYIRLIQMAAALVHIRHVSCDLYPGIPVIFCGDFNSTPSTGMYHFVINGSVPEDHEDWASNGEEERCGMSLTHCFKLKSACGEPAYTNYVGGFHGCLDYIFIDLNALEVEQVIPLPSHEEVTTHQALPSVSHPSDHIALVCDLKWK
uniprot
proteins
ec_number
3.1.13.4
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
function
FUNCTION: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells. {ECO:0000250|UniProtKB:Q6L8Q7}.
uniprot
proteins
mass_dalton
67176
uniprot
proteins
protein_family
CCR4/nocturin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
608
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q6L8Q7}.
uniprot
proteins