SH2B2
entrez
10603
canonical
uniprot
O14492
canonical
ensembl
ENSG00000160999
resolver
ensp
ENSP00000401883
resolver
ensp
ENSP00000440273
resolver
ensp
ENSP00000557028
resolver
ensp
ENSP00000557030
resolver
ensp
ENSP00000557031
resolver
ensp
ENSP00000557036
resolver
ensp
ENSP00000639983
resolver
genesymbol
SH2B2
resolver
genesymbol_syn
APS
resolver
hgnc
HGNC:17381
resolver
uniprot
A0A0A0MTI2
resolver
uniprot
A6ND74
resolver
uniprot_entry
SH2B2_HUMAN
resolver
uniprot_sec
A0A0A0MTI2
resolver
uniprot_sec
A6ND74
resolver
amino_acid_sequence
MNGAGPGPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGASFSRHFAANFLDVFGEEVRRVLVAGPTTRGAAVSAEAMEPELADTSALKAAPYGHSRSSEDVSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPDAAAAPRTAEPRDKWTRRLRLSRTLAAKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLRRAVAEERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVVTAPHSRGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPEPGPTPPAAPASPACWSDSPGQHYFSSLAAAACPPASPSDAAGASSSSASSSSAASGPAPPRPVEGQLSARSRSNSAERLLEAVAATAAEEPPEAAPGRARAVENQYSFY
uniprot
proteins
function
FUNCTION: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. {ECO:0000269|PubMed:10374881, ECO:0000269|PubMed:12400014, ECO:0000269|PubMed:15378031, ECO:0000269|PubMed:9989826}.
uniprot
proteins
mass_dalton
67738
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation with cytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex. {ECO:0000250|UniProtKB:Q9JID9, ECO:0000269|PubMed:10374881, ECO:0000269|PubMed:9233773, ECO:0000269|PubMed:9989826}.
uniprot
proteins
protein_family
SH2B adapter family
uniprot
proteins
pubmed
10374881
uniprot
proteins
pubmed
12400014
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15378031
uniprot
proteins
pubmed
16129412
uniprot
proteins
pubmed
9233773
uniprot
proteins
pubmed
9989826
uniprot
proteins
sequence_length
632
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9989826}. Cell membrane {ECO:0000269|PubMed:9989826}. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region.
uniprot
proteins