Acp2
entrez
24162
canonical
uniprot
P20611
canonical
ensembl
ENSRNOG00000013594
resolver
ensp
ENSRNOP00000018620
resolver
ensp
ENSRNOP00000105616
resolver
enst
ENSRNOT00000018620
resolver
enst
ENSRNOT00000123449
resolver
genesymbol
Acp2
resolver
uniprot
A0ABK0LVD4
resolver
uniprot
F7F1A3
resolver
uniprot
Q642D2
resolver
uniprot_entry
A0ABK0LVD4_RAT
resolver
uniprot_entry
F7F1A3_RAT
resolver
uniprot_entry
PPAL_RAT
resolver
uniprot_sec
Q642D2
resolver
activity_regulation
ACTIVITY REGULATION: Phosphatase activity is inhibited by L(+)-tartrate. {ECO:0000250|UniProtKB:P11117}.
uniprot
proteins
amino_acid_sequence
MAGRQSGWSQAALLQFLLGMCLMVMPPIQARSLRFVTLLYRHGDRSPVKAYPKDPYQEEKWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNASYHRQEVYVRSTDFDRTLMSAEANLAGLFPPTEVQHFNPNISWQPIPVHTVPITEDRLLKFPLGPCPRYEQLQNETRQTPEYQNMSIQNAQFLDMVANETGLMNLTLETIWNVYDTLFCEQTHGLLLPPWASPQTVQRLSQLKDFSFLFLFGIHDQVQKARLQGGVLLAQILKNLTLMATTSQFPKLLVYSAHDTTLVALQMALNVYNGKQAPYASCHIFELYQEDNGNFSVEMYFRNDSKKAPWPLTLPGCPHRCPLQDFLRLTEPVIPKDWQKECQLASDTADTEVIVALAVCGSILFLLIVLLLTVLFRMQAQPPGYHHVADREDHA
uniprot
proteins
ec_number
3.1.3.2
uniprot
proteins
function
FUNCTION: Lysosomal acid phosphatase that catalyzes the hydrolysis of orthophosphoric monoesters to alcohols and phosphate under acidic conditions (By similarity). May contribute to the removal of mannose-6-phosphate (Man6P) from lysosomal proteins after their delivery to lysosomes, acting in concert with ACP5 (By similarity). {ECO:0000250|UniProtKB:P11117, ECO:0000250|UniProtKB:P24638}.
uniprot
proteins
mass_dalton
48405
uniprot
proteins
post_translational_modification
PTM: The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Histidine acid phosphatase family
uniprot
proteins
pubmed
2764916
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:P11117}; Single-pass membrane protein {ECO:0000255}; Lumenal side {ECO:0000250|UniProtKB:P11117}. Lysosome lumen {ECO:0000250|UniProtKB:P11117}. Note=The soluble form arises by proteolytic processing of the membrane-bound form. {ECO:0000250|UniProtKB:P11117}.
uniprot
proteins
transmembrane_region
TRANSMEM 381..401; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins