Eif3h
entrez
299899
canonical
uniprot
Q6P9U8
canonical
ensembl
ENSRNOG00000004252
resolver
ensembl
ENSRNOG00055021689
resolver
ensembl
ENSRNOG00060003443
resolver
ensembl
ENSRNOG00065014836
resolver
ensp
ENSRNOP00000058501
resolver
ensp
ENSRNOP00055030248
resolver
ensp
ENSRNOP00060004141
resolver
ensp
ENSRNOP00065019169
resolver
enst
ENSRNOT00055037161
resolver
enst
ENSRNOT00060005682
resolver
enst
ENSRNOT00065024567
resolver
genesymbol
Eif3h
resolver
genesymbol_syn
Eif3s3
resolver
uniprot_entry
EIF3H_RAT
resolver
amino_acid_sequence
MASRKEGTGSTATSSSSTGGAVGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKANITFEHMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKNLQLLMDRVDEMSQDIIKYNTYMRNSSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPHQAPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYSN
uniprot
proteins
function
FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000255|HAMAP-Rule:MF_03007}.
uniprot
proteins
mass_dalton
39905
uniprot
proteins
protein_family
EIF-3 subunit H family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
uniprot
proteins