MOGAT3
entrez
346606
canonical
uniprot
Q86VF5
canonical
ensembl
ENSG00000106384
resolver
ensp
ENSP00000223114
resolver
ensp
ENSP00000368734
resolver
ensp
ENSP00000403756
resolver
genesymbol
MOGAT3
resolver
genesymbol_syn
DC7
resolver
genesymbol_syn
DGAT2L7
resolver
hgnc
HGNC:23249
resolver
uniprot
Q496A6
resolver
uniprot
Q496A7
resolver
uniprot
Q496A8
resolver
uniprot
Q9UDW7
resolver
uniprot_entry
MOGT3_HUMAN
resolver
uniprot_sec
Q496A6
resolver
uniprot_sec
Q496A7
resolver
uniprot_sec
Q496A8
resolver
uniprot_sec
Q9UDW7
resolver
amino_acid_sequence
MGVATTLQPPTTSKTLQKQHLEAVGAYQYVLTFLFMGPFFSLLVFVLLFTSLWPFSVFYLVWLYVDWDTPNQGGRRSEWIRNRAIWRQLRDYYPVKLVKTAELPPDRNYVLGAHPHGIMCTGFLCNFSTESNGFSQLFPGLRPWLAVLAGLFYLPVYRDYIMSFGLCPVSRQSLDFILSQPQLGQAVVIMVGGAHEALYSVPGEHCLTLQKRKGFVRLALRHGASLVPVYSFGENDIFRLKAFATGSWQHWCQLTFKKLMGFSPCIFWGRGLFSATSWGLLPFAVPITTVVGRPIPVPQRLHPTEEEVNHYHALYMTALEQLFEEHKESCGVPASTCLTFI
uniprot
proteins
ec_number
2.3.1.20
uniprot
proteins
ec_number
2.3.1.22
uniprot
proteins
function
FUNCTION: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {ECO:0000269|PubMed:12618427, ECO:0000269|PubMed:27184406, ECO:0000269|PubMed:28420705}.
uniprot
proteins
mass_dalton
38730
uniprot
proteins
mutagenesis
MUTAGEN 265; /note="C->A: Reduces 60% 2-acylglycerol O-acyltransferase activity. No effect on diacylglycerol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:27184406"; MUTAGEN 265; /note="C->Y: Catalitically inactive. No 2-acylglycerol O-acyltransferase neither diacylglycerol O-acyltransferase activities."; /evidence="ECO:0000269|PubMed:27184406
uniprot
proteins
pathway_participation
PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis. {ECO:0000269|PubMed:27184406}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination leads to proteasomal degradation. {ECO:0000269|PubMed:27184406}.
uniprot
proteins
protein_family
Diacylglycerol acyltransferase family
uniprot
proteins
pubmed
12618427
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16214399
uniprot
proteins
pubmed
18768481
uniprot
proteins
pubmed
27184406
uniprot
proteins
pubmed
28420705
uniprot
proteins
sequence_length
341
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27184406}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27184406}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..49; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 50..70; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 137..157; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins