POSTN
entrez
10631
canonical
uniprot
Q15063
canonical
ensembl
ENSG00000133110
resolver
ensp
ENSP00000369066
resolver
ensp
ENSP00000369067
resolver
ensp
ENSP00000369071
resolver
ensp
ENSP00000369073
resolver
ensp
ENSP00000437953
resolver
ensp
ENSP00000437959
resolver
ensp
ENSP00000525967
resolver
ensp
ENSP00000525968
resolver
ensp
ENSP00000525969
resolver
ensp
ENSP00000525971
resolver
genesymbol
POSTN
resolver
genesymbol_syn
OSF2
resolver
hgnc
HGNC:16953
resolver
uniprot
B1ALD8
resolver
uniprot
B1ALD9
resolver
uniprot
C0IMJ1
resolver
uniprot
C0IMJ2
resolver
uniprot
C0IMJ4
resolver
uniprot
D2KRH7
resolver
uniprot
F5H628
resolver
uniprot
Q15064
resolver
uniprot
Q29XZ0
resolver
uniprot
Q3KPJ5
resolver
uniprot
Q5VSY5
resolver
uniprot
Q8IZF9
resolver
uniprot_entry
POSTN_HUMAN
resolver
uniprot_sec
B1ALD8
resolver
uniprot_sec
B1ALD9
resolver
uniprot_sec
C0IMJ1
resolver
uniprot_sec
C0IMJ2
resolver
uniprot_sec
C0IMJ4
resolver
uniprot_sec
D2KRH7
resolver
uniprot_sec
F5H628
resolver
uniprot_sec
Q15064
resolver
uniprot_sec
Q29XZ0
resolver
uniprot_sec
Q3KPJ5
resolver
uniprot_sec
Q5VSY5
resolver
uniprot_sec
Q8IZF9
resolver
amino_acid_sequence
MIPFLPMFSLLLLLIVNPINANNHYDKILAHSRIRGRDQGPNVCALQQILGTKKKYFSTCKNWYKKSICGQKTTVLYECCPGYMRMEGMKGCPAVLPIDHVYGTLGIVGATTTQRYSDASKLREEIEGKGSFTYFAPSNEAWDNLDSDIRRGLESNVNVELLNALHSHMINKRMLTKDLKNGMIIPSMYNNLGLFINHYPNGVVTVNCARIIHGNQIATNGVVHVIDRVLTQIGTSIQDFIEAEDDLSSFRAAAITSDILEALGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSESIMGGAVFETLEGNTIEIGCDGDSITVNGIKMVNKKDIVTNNGVIHLIDQVLIPDSAKQVIELAGKQQTTFTDLVAQLGLASALRPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKVGLNELYNGQILETIGGKQLRVFVYRTAVCIENSCMEKGSKQGRNGAIHIFREIIKPAEKSLHEKLKQDKRFSTFLSLLEAADLKELLTQPGDWTLFVPTNDAFKGMTSEEKEILIRDKNALQNIILYHLTPGVFIGKGFEPGVTNILKTTQGSKIFLKEVNDTLLVNELKSKESDIMTTNGVIHVVDKLLYPADTPVGNDQLLEILNKLIKYIQIKFVRGSTFKEIPVTVYTTKIITKVVEPKIKVIEGSLQPIIKTEGPTLTKVKIEGEPEFRLIKEGETITEVIHGEPIIKKYTKIIDGVPVEITEKETREERIITGPEIKYTRISTGGGETEETLKKLLQEEVTKVTKFIEGGDGHLFEDEEIKRLLQGDTPVRKLQANKKVQGSRRRLREGRSQ
uniprot
proteins
function
FUNCTION: Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). {ECO:0000250|UniProtKB:Q62009, ECO:0000269|PubMed:12235007}.
uniprot
proteins
mass_dalton
93314
uniprot
proteins
mutagenesis
MUTAGEN 60; /note="C->A: No effect on homodimerization."; /evidence="ECO:0000269|PubMed:29754429"; MUTAGEN 463..465; /note="RTA->NTS: Loss of homodimerization."; /evidence="ECO:0000269|PubMed:29754429
uniprot
proteins
post_translational_modification
PTM: Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding (PubMed:18450759). According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues (PubMed:26273833). {ECO:0000269|PubMed:18450759, ECO:0000269|PubMed:26273833}.
uniprot
proteins
pubmed
11550156
uniprot
proteins
pubmed
12235007
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15082792
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
18450759
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21763681
uniprot
proteins
pubmed
22079858
uniprot
proteins
pubmed
23946676
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26273833
uniprot
proteins
pubmed
29086898
uniprot
proteins
pubmed
29754429
uniprot
proteins
pubmed
8363580
uniprot
proteins
sequence_length
836
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:Q62009}. Secreted {ECO:0000269|PubMed:18450759, ECO:0000269|PubMed:26273833}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12235007, ECO:0000269|PubMed:18450759}. Note=Colocalizes with BMP1 in the Golgi. {ECO:0000250|UniProtKB:Q62009}.
uniprot
proteins