Gria3
entrez
53623
canonical
uniprot
Q9Z2W9
canonical
ensembl
ENSMUSG00000001986
resolver
ensp
ENSMUSP00000075687
resolver
ensp
ENSMUSP00000110755
resolver
ensp
ENSMUSP00000131523
resolver
ensp
ENSMUSP00000278606
resolver
ensp
ENSMUSP00000278607
resolver
ensp
ENSMUSP00000278609
resolver
ensp
ENSMUSP00000278615
resolver
enst
ENSMUST00000076349
resolver
enst
ENSMUST00000115103
resolver
enst
ENSMUST00000165288
resolver
genesymbol
Gria3
resolver
genesymbol_syn
GluA3
resolver
genesymbol_syn
Glur3
resolver
genesymbol_syn
Kiaa4184
resolver
uniprot
A2VDF4
resolver
uniprot
B0QZW1
resolver
uniprot
Q0VGS8
resolver
uniprot
Q3UY17
resolver
uniprot
Q5DTJ0
resolver
uniprot_entry
B0QZW1_MOUSE
resolver
uniprot_entry
GRIA3_MOUSE
resolver
uniprot_entry
Q0VGS8_MOUSE
resolver
uniprot_entry
Q3UY17_MOUSE
resolver
uniprot_sec
A2VDF4
resolver
uniprot_sec
Q5DTJ0
resolver
amino_acid_sequence
MGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGYYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDIQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDIVLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
uniprot
proteins
function
FUNCTION: Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation (PubMed:28103481). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of calcium (By similarity). The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). {ECO:0000250|UniProtKB:P19492, ECO:0000250|UniProtKB:P42263, ECO:0000269|PubMed:28103481}.
uniprot
proteins
mass_dalton
100527
uniprot
proteins
protein_family
GRIA3 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16129400
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20163115
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28103481
uniprot
proteins
pubmed
33981040
uniprot
proteins
sequence_length
888
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P19492}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19492}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P19492}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19492}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P19492}.
uniprot
proteins
transmembrane_region
TRANSMEM 547..567; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 622..642; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 818..838; /note="Helical; Name=M4"; /evidence="ECO:0000250
uniprot
proteins