PTGER3
entrez
5733
canonical
uniprot
P43115
canonical
ensembl
ENSG00000050628
resolver
ensp
ENSP00000302313
resolver
ensp
ENSP00000349003
resolver
ensp
ENSP00000359962
resolver
ensp
ENSP00000359969
resolver
ensp
ENSP00000418073
resolver
ensp
ENSP00000424340
resolver
ensp
ENSP00000486617
resolver
enst
ENST00000361210
resolver
genesymbol
PTGER3
resolver
hgnc
HGNC:9595
resolver
uniprot
B0AZN4
resolver
uniprot
B1AK19
resolver
uniprot
B5BUP5
resolver
uniprot
F6UC15
resolver
uniprot
O00325
resolver
uniprot
O00326
resolver
uniprot
Q12943
resolver
uniprot
Q12944
resolver
uniprot
Q12945
resolver
uniprot
Q147X8
resolver
uniprot
Q16546
resolver
uniprot
Q5CZ59
resolver
uniprot
Q5CZ61
resolver
uniprot
Q5CZ62
resolver
uniprot
Q5CZ63
resolver
uniprot
Q5CZ64
resolver
uniprot_entry
F6UC15_HUMAN
resolver
uniprot_entry
O00325_HUMAN
resolver
uniprot_entry
PE2R3_HUMAN
resolver
uniprot_sec
B0AZN4
resolver
uniprot_sec
B1AK19
resolver
uniprot_sec
B5BUP5
resolver
uniprot_sec
O00326
resolver
uniprot_sec
Q12943
resolver
uniprot_sec
Q12944
resolver
uniprot_sec
Q12945
resolver
uniprot_sec
Q147X8
resolver
uniprot_sec
Q16546
resolver
uniprot_sec
Q5CZ59
resolver
uniprot_sec
Q5CZ61
resolver
uniprot_sec
Q5CZ62
resolver
uniprot_sec
Q5CZ63
resolver
uniprot_sec
Q5CZ64
resolver
amino_acid_sequence
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
uniprot
proteins
function
FUNCTION: Receptor for prostaglandin E2 (PGE2) (PubMed:7883006, PubMed:7981210, PubMed:8117308, PubMed:8135729, PubMed:8307176). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium (PubMed:7883006, PubMed:7981210, PubMed:8117308, PubMed:8135729). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity). {ECO:0000250|UniProtKB:P30557, ECO:0000269|PubMed:7883006, ECO:0000269|PubMed:7981210, ECO:0000269|PubMed:8117308, ECO:0000269|PubMed:8135729, ECO:0000269|PubMed:8307176}.
uniprot
proteins
mass_dalton
43310
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18023986
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
7476918
uniprot
proteins
pubmed
7883006
uniprot
proteins
pubmed
7981210
uniprot
proteins
pubmed
8075855
uniprot
proteins
pubmed
8117308
uniprot
proteins
pubmed
8135729
uniprot
proteins
pubmed
8307176
uniprot
proteins
pubmed
9073510
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7883006, ECO:0000269|PubMed:7981210, ECO:0000269|PubMed:8117308, ECO:0000269|PubMed:8307176}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 54..78; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 132..153; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 176..197; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 228..253; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 284..307; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 328..349; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins