Adcyap1r1
entrez
24167
canonical
uniprot
P32215
canonical
ensembl
ENSRNOG00000012098
resolver
ensembl
ENSRNOG00055011238
resolver
ensembl
ENSRNOG00060023373
resolver
ensembl
ENSRNOG00065012082
resolver
ensp
ENSRNOP00000016175
resolver
ensp
ENSRNOP00000030759
resolver
ensp
ENSRNOP00000044267
resolver
ensp
ENSRNOP00000050048
resolver
genesymbol
Adcyap1r1
resolver
uniprot
Q63414
resolver
uniprot_entry
PACR_RAT
resolver
uniprot_sec
Q63414
resolver
amino_acid_sequence
MARVLQLSLTALLLPVAIAMHSDCIFKKEQAMCLERIQRANDLMGLNESSPGCPGMWDNITCWKPAQVGEMVLVSCPEVFRIFNPDQVWMTETIGDSGFADSNSLEITDMGVVGRNCTEDGWSEPFPHYFDACGFDDYEPESGDQDYYYLSVKALYTVGYSTSLATLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSSHCFVSTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWAVLRLYFDDAGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIIILVQKLQSPDMGGNESSIYLTNLRLRVPKKTREDPLPVPSDQHSPPFLSCVQKCYCKPQRAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFTMDFKHRHPSLASSGVNGGTQLSILSKSSSQLRMSSLPADNLAT
uniprot
proteins
function
FUNCTION: G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds both PACAP27 and PACAP38 bioactive peptides. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. {ECO:0000250|UniProtKB:P41586}.
uniprot
proteins
mass_dalton
59637
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
7687425
uniprot
proteins
pubmed
8392197
uniprot
proteins
pubmed
8394723
uniprot
proteins
pubmed
8394834
uniprot
proteins
pubmed
8396727
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41586}.
uniprot
proteins
transmembrane_region
TRANSMEM 152..176; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P41586"; TRANSMEM 187..207; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P41586"; TRANSMEM 223..248; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P41586"; TRANSMEM 267..289; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P41586"; TRANSMEM 302..328; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P41586"; TRANSMEM 347..429; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P41586"; TRANSMEM 435..458; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P41586
uniprot
proteins