CNBP
entrez
7555
canonical
uniprot
P62633
canonical
ensembl
ENSG00000169714
resolver
ensp
ENSP00000399488
resolver
ensp
ENSP00000400444
resolver
ensp
ENSP00000410619
resolver
ensp
ENSP00000410769
resolver
ensp
ENSP00000421323
resolver
ensp
ENSP00000581078
resolver
genesymbol
CNBP
resolver
genesymbol_syn
RNF163
resolver
genesymbol_syn
ZNF9
resolver
hgnc
HGNC:13164
resolver
uniprot
A0A0S2Z4K2
resolver
uniprot
A0A0S2Z4Q3
resolver
uniprot
A8K7V4
resolver
uniprot
B2RAV9
resolver
uniprot
B4DP17
resolver
uniprot
D3DNB9
resolver
uniprot
D3DNC0
resolver
uniprot
D3DNC1
resolver
uniprot
E9PDR7
resolver
uniprot
P20694
resolver
uniprot
Q4JGY0
resolver
uniprot
Q4JGY1
resolver
uniprot
Q5QJR0
resolver
uniprot
Q5U0E9
resolver
uniprot
Q6PJI7
resolver
uniprot
Q96NV3
resolver
uniprot_entry
A0A0S2Z4K2_HUMAN
resolver
uniprot_entry
A0A0S2Z4Q3_HUMAN
resolver
uniprot_entry
CNBP_HUMAN
resolver
uniprot_sec
A8K7V4
resolver
uniprot_sec
B2RAV9
resolver
uniprot_sec
B4DP17
resolver
uniprot_sec
D3DNB9
resolver
uniprot_sec
D3DNC0
resolver
uniprot_sec
D3DNC1
resolver
uniprot_sec
E9PDR7
resolver
uniprot_sec
P20694
resolver
uniprot_sec
Q4JGY0
resolver
uniprot_sec
Q4JGY1
resolver
uniprot_sec
Q5QJR0
resolver
uniprot_sec
Q5U0E9
resolver
uniprot_sec
Q6PJI7
resolver
uniprot_sec
Q96NV3
resolver
amino_acid_sequence
MSSNECFKCGRSGHWARECPTGGGRGRGMRSRGRGGFTSDRGFQFVSSSLPDICYRCGESGHLAKDCDLQEDACYNCGRGGHIAKDCKEPKREREQCCYNCGKPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYRCGESGHLARECTIEATA
uniprot
proteins
disease_involvement
DISEASE: Dystrophia myotonica 2 (DM2) [MIM:602668]: A multisystem disease characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare cases. Note=The disease is caused by variants affecting the gene represented in this entry. The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene.
uniprot
proteins
function
FUNCTION: Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (PubMed:2562787). Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner (By similarity). {ECO:0000250|UniProtKB:P53996, ECO:0000250|UniProtKB:P62634, ECO:0000269|PubMed:2562787}.; FUNCTION: [Isoform 1]: Binds G-rich elements in target mRNA coding sequences (PubMed:28329689). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (PubMed:28329689). {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 2]: Binds to RNA. {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 4]: Binds to RNA. {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 5]: Binds to RNA. {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 6]: Binds to RNA. {ECO:0000269|PubMed:28329689}.; FUNCTION: [Isoform 8]: Binds to RNA. {ECO:0000269|PubMed:28329689}.
uniprot
proteins
mass_dalton
19463
uniprot
proteins
mutagenesis
MUTAGEN 25; /note="R->K: Significantly reduces methylation; when associated with K-27."; /evidence="ECO:0000269|PubMed:24726729"; MUTAGEN 27; /note="R->K: Significantly reduces methylation; when associated with K-25."; /evidence="ECO:0000269|PubMed:24726729
uniprot
proteins
post_translational_modification
PTM: Arginine methylation by PRMT1 in the Arg/Gly-rich region impedes RNA binding. {ECO:0000269|PubMed:24726729}.
uniprot
proteins
pubmed
11486088
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24726729
uniprot
proteins
pubmed
2562787
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28329689
uniprot
proteins
pubmed
7590281
uniprot
proteins
sequence_length
177
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53996}. Cytoplasm {ECO:0000269|PubMed:28329689}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P53996}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:28329689}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:28329689}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:28329689}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:28329689}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000269|PubMed:28329689}.; SUBCELLULAR LOCATION: [Isoform 8]: Cytoplasm {ECO:0000269|PubMed:28329689}.
uniprot
proteins