FLT3LG
entrez
2323
canonical
uniprot
P49771
canonical
ensembl
ENSG00000090554
resolver
ensp
ENSP00000204637
resolver
ensp
ENSP00000468977
resolver
ensp
ENSP00000469181
resolver
ensp
ENSP00000469613
resolver
ensp
ENSP00000470453
resolver
ensp
ENSP00000562415
resolver
ensp
ENSP00000674261
resolver
ensp
ENSP00000674262
resolver
ensp
ENSP00000771786
resolver
ensp
ENSP00000771788
resolver
ensp
ENSP00000771790
resolver
genesymbol
FLT3LG
resolver
hgnc
HGNC:3766
resolver
uniprot
A0AVC2
resolver
uniprot
B7ZLY4
resolver
uniprot
B9EGH2
resolver
uniprot
Q05C96
resolver
uniprot_entry
B7ZLY4_HUMAN
resolver
uniprot_entry
FLT3L_HUMAN
resolver
uniprot_sec
A0AVC2
resolver
uniprot_sec
B9EGH2
resolver
uniprot_sec
Q05C96
resolver
amino_acid_sequence
MTVLAPAWSPTTYLLLLLLLSSGLSGTQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTVASNLQDEELCGGLWRLVLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCLRFVQTNISRLLQETSEQLVALKPWITRQNFSRCLELQCQPDSSTLPPPWSPRPLEATAPTAPQPPLLLLLLLPVGLLLLAAAWCLHWQRTRRRTPRPGEQVPPVPSPQDLLLVEH
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 125 (IMD125) [MIM:620926]: An autosomal recessive immunologic disorder characterized by failure to thrive and chronic diarrhea in infancy, and recurrent bacterial, viral, and fungal infections. Patients have severe human papilloma virus (HPV) infections with disseminated common warts, and the bone marrow is hypoplastic with low levels of CD34+ hematopoietic stem cells. Counts of B cells, monocytes, and dendritic cells are low in patients blood. {ECO:0000269|PubMed:38701783}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. Required for the development of B cells, and dendritic cells (DCs). {ECO:0000269|PubMed:38701783}.
uniprot
proteins
mass_dalton
26416
uniprot
proteins
pubmed
10881197
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
38701783
uniprot
proteins
pubmed
7566977
uniprot
proteins
pubmed
8145851
uniprot
proteins
pubmed
8180375
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins