Atp1a3
entrez
232975
canonical
uniprot
Q6PIC6
canonical
ensembl
ENSMUSG00000040907
resolver
ensp
ENSMUSP00000079691
resolver
ensp
ENSMUSP00000099922
resolver
ensp
ENSMUSP00000143735
resolver
ensp
ENSMUSP00000187723
resolver
enst
ENSMUST00000080882
resolver
enst
ENSMUST00000102858
resolver
enst
ENSMUST00000196684
resolver
genesymbol
Atp1a3
resolver
uniprot
A0A0G2JGX4
resolver
uniprot
F6R1F1
resolver
uniprot
Q8R0E8
resolver
uniprot
Q8VCE0
resolver
uniprot_entry
A0A0G2JGX4_MOUSE
resolver
uniprot_entry
AT1A3_MOUSE
resolver
uniprot_entry
F6R1F1_MOUSE
resolver
uniprot_entry
Q8R0E8_MOUSE
resolver
uniprot_entry
Q8VCE0_MOUSE
resolver
amino_acid_sequence
MGDKKDDKSSPKKSKAKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCATILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY
uniprot
proteins
ec_number
7.2.2.13
uniprot
proteins
function
FUNCTION: Neuron-specific alpha catalytic component of the Na(+)/K(+)-transporting ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (By similarity). Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze against their electrochemical gradients to maintain ion concentration gradients across the membranes (By similarity). In the brain, ATP1A3 is critical for neuronal cell signaling and for maintenance of electrochemical stability, enabling cell excitation and action potential propagation (PubMed:19666602). {ECO:0000250|UniProtKB:P05023, ECO:0000250|UniProtKB:P13637, ECO:0000269|PubMed:19666602}.
uniprot
proteins
mass_dalton
111692
uniprot
proteins
mutagenesis
MUTAGEN 810; /note="I->N: In Myk strain; displays spontaneous seizures and neuronal hyperexcitability in heterozygotes and perinatal death in homozygote. Reduces Na(+)/K(+)-ATPase activity by 42% in Myk-/+ brain."; /evidence="ECO:0000269|PubMed:19666602
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIC subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15648052
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19666602
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32301109
uniprot
proteins
sequence_length
1013
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P13637}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P13637}.
uniprot
proteins
transmembrane_region
TRANSMEM 91..107; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 119..139; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 282..303; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 307..345; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 767..786; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 794..809; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 840..862; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 905..927; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 943..966; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 975..995; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P13637
uniprot
proteins