Neurl1
entrez
18011
canonical
uniprot
Q923S6
canonical
ensembl
ENSMUSG00000006435
resolver
ensp
ENSMUSP00000107438
resolver
ensp
ENSMUSP00000107439
resolver
genesymbol
Neurl1
resolver
genesymbol
Neurl1a
resolver
genesymbol_syn
Neurl
resolver
genesymbol_syn
Neurl1a
resolver
uniprot
Q499W5
resolver
uniprot
Q91ZT6
resolver
uniprot
Q9CWF1
resolver
uniprot
Q9QWF1
resolver
uniprot_entry
NEUL1_MOUSE
resolver
uniprot_entry
Q499W5_MOUSE
resolver
uniprot_sec
Q91ZT6
resolver
uniprot_sec
Q9CWF1
resolver
uniprot_sec
Q9QWF1
resolver
amino_acid_sequence
MGNNFSSVSSLQRGNPSRASRGHPQNLKDSIGGSFPVPSHRCHHKQKHCPPTLSGGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFYRINESAAMLFFSGVRTVDPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRCEADEARLSVSLCDLNVPGADGDDGAPPAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARLEHGRDERALVFTSRPVRVAETIFIKVTRSGGGRAGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAAGMQLCVDASQPLWMLFSLHGAITQVRILGSTIMTERGGPSLPCSPASTPTSPSALGIRLSDPLLSTCGSGPLGGSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYSCGLRLKKALHACCPICRRPIKDIIKTYRSS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway. {ECO:0000269|PubMed:18077452, ECO:0000269|PubMed:22153079}.
uniprot
proteins
mass_dalton
61778
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Myristoylation is a determinant of membrane targeting. {ECO:0000269|PubMed:18077452}.
uniprot
proteins
pubmed
11481456
uniprot
proteins
pubmed
11585928
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18077452
uniprot
proteins
pubmed
19723503
uniprot
proteins
pubmed
22153079
uniprot
proteins
sequence_length
574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:22153079}; Peripheral membrane protein {ECO:0000269|PubMed:22153079}. Perikaryon {ECO:0000269|PubMed:22153079}. Cell projection, dendrite {ECO:0000269|PubMed:22153079}. Postsynaptic density {ECO:0000269|PubMed:22153079}. Note=Colocalized with JAG1 at the cell surface (By similarity). Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons. {ECO:0000250}.
uniprot
proteins