CALCR
entrez
799
canonical
uniprot
P30988
canonical
ensembl
ENSG00000004948
resolver
ensp
ENSP00000377959
resolver
ensp
ENSP00000389295
resolver
ensp
ENSP00000497687
resolver
enst
ENST00000649521
resolver
genesymbol
CALCR
resolver
hgnc
HGNC:1440
resolver
uniprot
A0A0A0MSQ7
resolver
uniprot
A0A0C4DG16
resolver
uniprot
A4D1G6
resolver
uniprot
F5H605
resolver
uniprot
O14585
resolver
uniprot
Q13941
resolver
uniprot
Q5ZGL8
resolver
uniprot
Q659U6
resolver
uniprot
Q6DJU8
resolver
uniprot
Q6T712
resolver
uniprot_entry
A0A0A0MSQ7_HUMAN
resolver
uniprot_entry
CALCR_HUMAN
resolver
uniprot_sec
A0A0C4DG16
resolver
uniprot_sec
A4D1G6
resolver
uniprot_sec
F5H605
resolver
uniprot_sec
O14585
resolver
uniprot_sec
Q13941
resolver
uniprot_sec
Q5ZGL8
resolver
uniprot_sec
Q659U6
resolver
uniprot_sec
Q6DJU8
resolver
uniprot_sec
Q6T712
resolver
activity_regulation
ACTIVITY REGULATION: Sensitive to cholera toxin.
uniprot
proteins
amino_acid_sequence
MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQQLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFKHPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLGCQRVTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCEGIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFPWRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRRPSNRSARAAAAAAEAGDIPIYICHQELRNEPANNQGEESAEIIPLNIIEQESSA
uniprot
proteins
function
FUNCTION: G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA) (PubMed:35324283, PubMed:38603770). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively (PubMed:35324283, PubMed:38603770). IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes (PubMed:35324283, PubMed:38603770). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:35324283, PubMed:7476993). {ECO:0000269|PubMed:35324283, ECO:0000269|PubMed:38603770, ECO:0000269|PubMed:7476993}.; FUNCTION: [Isoform 2]: Non-functional protein. Unable to couple to G proteins and activate adenylyl cyclase (PubMed:7476993). Does not undergo receptor internalization following ligand binding (PubMed:7476993). {ECO:0000269|PubMed:7476993}.
uniprot
proteins
mass_dalton
55345
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
10570950
uniprot
proteins
pubmed
10860825
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
1331173
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15086532
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15563840
uniprot
proteins
pubmed
22946511
uniprot
proteins
pubmed
32035902
uniprot
proteins
pubmed
35324283
uniprot
proteins
pubmed
38603770
uniprot
proteins
pubmed
7476993
uniprot
proteins
pubmed
7588285
uniprot
proteins
pubmed
7720653
uniprot
proteins
pubmed
7733946
uniprot
proteins
pubmed
8078488
uniprot
proteins
pubmed
8143880
uniprot
proteins
pubmed
9571205
uniprot
proteins
pubmed
9675109
uniprot
proteins
pubmed
9817931
uniprot
proteins
sequence_length
474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:35324283}; Multi-pass membrane protein {ECO:0000269|PubMed:35324283}.
uniprot
proteins
transmembrane_region
TRANSMEM 147..169; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:35324283, ECO:0007744|PDB:7TYX"; TRANSMEM 182..202; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:35324283, ECO:0007744|PDB:7TYX"; TRANSMEM 220..242; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:35324283, ECO:0007744|PDB:7TYX"; TRANSMEM 260..280; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:35324283, ECO:0007744|PDB:7TYX"; TRANSMEM 297..320; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:35324283, ECO:0007744|PDB:7TYX"; TRANSMEM 341..359; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:35324283, ECO:0007744|PDB:7TYX"; TRANSMEM 368..394; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:35324283, ECO:0007744|PDB:7TYX
uniprot
proteins