Fcn2
entrez
114091
canonical
uniprot
P57756
canonical
ensembl
ENSRNOG00000009342
resolver
ensembl
ENSRNOG00055006306
resolver
ensembl
ENSRNOG00060027892
resolver
ensembl
ENSRNOG00065020913
resolver
ensp
ENSRNOP00000012494
resolver
ensp
ENSRNOP00055007923
resolver
ensp
ENSRNOP00060040376
resolver
ensp
ENSRNOP00065028631
resolver
enst
ENSRNOT00000012494
resolver
enst
ENSRNOT00055010239
resolver
enst
ENSRNOT00060048461
resolver
enst
ENSRNOT00065035530
resolver
genesymbol
Fcn2
resolver
genesymbol_syn
Fcnb
resolver
uniprot_entry
FCN2_RAT
resolver
amino_acid_sequence
MVLGSAALFVLSLCVTELTLHAADTCPEVKVLDLEGSNKLTILQGCPGLPGALGPKGEAGAKGDRGESGLPGHPGKAGPTGPKGDRGEKGVRGEKGDTGPSQSCATGPRTCKELLTRGYFLTGWYTIYLPDCRPLTVLCDMDTDGGGWTVFQRRIDGTVDFFRDWTSYKQGFGSQLGEFWLGNDNIHALTTQGTNELRVDLADFDGNHDFAKYSSFQIQGEAEKYKLILGNFLGGGAGDSLTSQNNMLFSTKDQDNDQGSSNCAVRYHGAWWYSDCHTSNLNGLYLRGLHKSYANGVNWKSWKGYNYSYKVSEMKVRLI
uniprot
proteins
function
FUNCTION: Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Specifically binds N-Acetylglucosamine (GlcNAc), as well as phosphocholine and lipoteichoic acid moieties on the surface of pathogens. {ECO:0000250|UniProtKB:Q15485}.
uniprot
proteins
mass_dalton
34684
uniprot
proteins
protein_family
Ficolin lectin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
319
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q15485}. Cell surface {ECO:0000250|UniProtKB:Q15485}. Note=Specifically binds carbohydrates on the surface of pathogens. {ECO:0000250|UniProtKB:Q15485}.
uniprot
proteins