Capn8
entrez
170725
canonical
uniprot
Q91VA3
canonical
ensembl
ENSMUSG00000038599
resolver
ensp
ENSMUSP00000047164
resolver
ensp
ENSMUSP00000129549
resolver
enst
ENSMUST00000048941
resolver
genesymbol
Capn8
resolver
genesymbol_syn
Ncl2
resolver
uniprot
A0A0R4J0K6
resolver
uniprot
Q059W1
resolver
uniprot
Q91UZ9
resolver
uniprot
Q920R7
resolver
uniprot_entry
A0A0R4J0K6_MOUSE
resolver
uniprot_entry
CAN8_MOUSE
resolver
uniprot_sec
Q059W1
resolver
uniprot_sec
Q91UZ9
resolver
uniprot_sec
Q920R7
resolver
activity_regulation
ACTIVITY REGULATION: The concentration of calcium for half-maximal activity is 0.3 mM. Inhibited by calpastatin and calpeptin. {ECO:0000269|PubMed:17646163}.
uniprot
proteins
amino_acid_sequence
MAALAAGISKQRAAAQGLGSNQNAVKYLGQDFETLRKQCLNSGVLFKDPEFPACPSALGYRDLGPGSAETQGIIWKRPTELCSNPQFIVGGATRTDIRQGGLGDCWLLAAIASLTLNEKLLYRVVPRDQSFQKNYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEEGNEFWSALLEKAYAKLNGSYEALAGGSTIEGFEDFTGGISEFYDLRKPPGNLYYTIQKALRKGSLLGCSIDVSNAAEAEATTRQKLVKGHAYSVTGVEEVDFRGLPEKLIRLRNPWGEVEWTGAWSDSAPEWNYIDPQKKGELDKRAEDGEFWMSFSDFLKQFSRLEICNLSPDSLSSEEIHKWNLVLFNGRWTRGSTAGGCQNYPATYWTNPQFKIHLDEVDEDQEEGTSEPCCTVLLGLMQKNRRRQRRIGQGMLSIGYAVYQIPKELENHTDEHLGRDFFQGRQPSTCSSTYMNLREVSSRVQLPPGQYLVVPSTFEPFKDGDFCLRVFSEKKAQALEIGDAVPGDPHEPHPRDMDGEDEHFWSLSEEFADKDSEISAHQLKRVLNGLLSKRTDMKFDGFNINTCREMISLLDGDGTGSLRPVEFKTLWLKICKYLEIYQEMDHSRAGTIDAHEMRTALKKAGFTLNNQVQQTIATRYACSKLGVDFDGFVACMIRLEILFKLFRLLDKDQNGIVQLSLAEWLCRALV
uniprot
proteins
ec_number
3.4.22.53
uniprot
proteins
function
FUNCTION: Calcium-regulated non-lysosomal thiol-protease (By similarity). Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex. {ECO:0000250, ECO:0000269|PubMed:16476741}.
uniprot
proteins
mass_dalton
79335
uniprot
proteins
mutagenesis
MUTAGEN 105; /note="C->S: Loss of activity."; /evidence="ECO:0000269|PubMed:17646163
uniprot
proteins
post_translational_modification
PTM: Undergoes autolytic cleavage between Ala-5 and Ala-6 which gives rise to fragments extending from Ala-6 to the C-terminus, Ala-6 to the EF-hand 2 domain and from Ala-6 to the beginning of domain III.
uniprot
proteins
protein_family
Peptidase C2 family
uniprot
proteins
pubmed
11523006
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16476741
uniprot
proteins
pubmed
17646163
uniprot
proteins
sequence_length
703
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000269|PubMed:16476741}.
uniprot
proteins