Dpp8
entrez
74388
canonical
uniprot
Q80YA7
canonical
ensembl
ENSMUSG00000032393
resolver
ensp
ENSMUSP00000034960
resolver
ensp
ENSMUSP00000126065
resolver
ensp
ENSMUSP00000182158
resolver
enst
ENSMUST00000034960
resolver
enst
ENSMUST00000167773
resolver
genesymbol
Dpp8
resolver
uniprot
Q9D4G6
resolver
uniprot_entry
DPP8_MOUSE
resolver
uniprot_sec
Q9D4G6
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by zinc (By similarity). Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfluorophosphate (By similarity). Specifically inhibited by isoindoline derivatives (By similarity). Inhibited by Val-boroPro (Talabostat, PT-100), a non-selective inhibitor, which triggers pyroptosis in monocytes and macrophages (PubMed:27820798, PubMed:29396289). {ECO:0000250|UniProtKB:Q6V1X1, ECO:0000269|PubMed:27820798, ECO:0000269|PubMed:29396289}.
uniprot
proteins
amino_acid_sequence
MKIPSGRCNMAAAMETEQLGVEIFETAECEEGNGESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRTDPDGPHSDRVYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIAAYDYHPGSGTFLFQAGSGIYHIKDGGPHGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNLVTREERRITYVHNELANMEEDPRSAGVATFVLQEEFDRYSGYWWCPQAERTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIVVDAAGGIIDVIDKELVQPFEILFEGVEYIARAGWTPEGKHAWSILLDRSQTHLQIVLISPELFIPVEDDAMDRQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQTHEDEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEITITSGEWEVLGRHGSNIWVDEARKLVYFEGTKDSPLEHHLYVTSYANPGEVVRLTDRGYSHSCCLSRHCDFFISKYSNQKNPHCVSLYKLSSPEDDPVHKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASQYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI
uniprot
proteins
ec_number
3.4.14.5
uniprot
proteins
function
FUNCTION: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (By similarity). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29396289). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (By similarity). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity). {ECO:0000250|UniProtKB:Q6V1X1, ECO:0000250|UniProtKB:Q86TI2, ECO:0000269|PubMed:27820798, ECO:0000269|PubMed:29396289}.
uniprot
proteins
mass_dalton
102186
uniprot
proteins
protein_family
DPPIV subfamily
uniprot
proteins
protein_family
Peptidase S9B family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27820798
uniprot
proteins
pubmed
29396289
uniprot
proteins
sequence_length
892
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6V1X1}.
uniprot
proteins