Ccdc134
entrez
500909
canonical
uniprot
Q5M862
canonical
ensembl
ENSRNOG00000007262
resolver
ensembl
ENSRNOG00055029105
resolver
ensembl
ENSRNOG00060031176
resolver
ensembl
ENSRNOG00065030314
resolver
ensp
ENSRNOP00000052900
resolver
ensp
ENSRNOP00055041488
resolver
ensp
ENSRNOP00060044885
resolver
ensp
ENSRNOP00065043001
resolver
enst
ENSRNOT00000056048
resolver
enst
ENSRNOT00055050402
resolver
enst
ENSRNOT00060054110
resolver
enst
ENSRNOT00065052281
resolver
genesymbol
Ccdc134
resolver
uniprot_entry
CC134_RAT
resolver
amino_acid_sequence
MDLLQSLAVFFVLLLPGTEVTGTLKSTLDPSLKIYKKMFEVKRREQLLALKNLAQLNDIHQQYKILDVMLKGLFKVLEDSRTVLIAADVLPDGPLPQDEKLKDAFSHVVENTAFFGDVVLRFPKIVHHYFDHNSNWNLLIRWGISFCNQTGVFDQGPHSPVLSLMAQELGITEKDSDFQNPFTIDRTEFIPSTDPFQKALREEEKRRKKEEKRKEIRKGPRISRSQSEL
uniprot
proteins
function
FUNCTION: Molecular adapter required to prevent protein hyperglycosylation of HSP90B1: during translation, associates with nascent HSP90B1 and the STT3A catalytic component of the OST-A complex and tethers them to a specialized translocon that forms a microenvironment for HSP90B1 folding. In the CCDC134-containing translocon, STT3A associates with the SRT pseudosubstrate motif of HSP90B1, preventing access to facultative glycosylation sites until folding is completed, preventing hyperglycosylation and subsequent degradation of HSP90B1. In extracellular secreted form, promotes proliferation and activation of CD8(+) T-cells, suggesting a cytokine-like function. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling. May also localize in the nucleus: enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated histone acetyltransferase activity. Has a critical role in the regulation of osteogenesis and bone development. {ECO:0000250|UniProtKB:Q9H6E4}.
uniprot
proteins
mass_dalton
26437
uniprot
proteins
post_translational_modification
PTM: O-glycosylated, with additional sialic acid modifications. {ECO:0000250|UniProtKB:Q9H6E4}.
uniprot
proteins
protein_family
CCDC134 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
229
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q9H6E4}. Secreted {ECO:0000250|UniProtKB:Q9H6E4}. Cytoplasm {ECO:0000250|UniProtKB:Q9H6E4}. Nucleus {ECO:0000250|UniProtKB:Q9H6E4}. Note=Mainly localizes to the endoplasmic reticulum. Accumulates in the nucleus in response to UV irradiation. {ECO:0000250|UniProtKB:Q9H6E4}.
uniprot
proteins