S1pr5
entrez
94226
canonical
uniprot
Q91X56
canonical
ensembl
ENSMUSG00000045087
resolver
ensp
ENSMUSP00000113843
resolver
enst
ENSMUST00000122088
resolver
genesymbol
S1pr5
resolver
genesymbol_syn
Edg8
resolver
genesymbol_syn
Lpb4
resolver
uniprot
Q99MN8
resolver
uniprot_entry
S1PR5_MOUSE
resolver
uniprot_sec
Q99MN8
resolver
amino_acid_sequence
MEPGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAAVCLAVCAFIVLENLAVLLVLVRHPRFHAPMFLLLGSLTLSDLLAGAAYATNILLSGPLTLRLSPALWFAREGGVFVALAASVLSLLAIALERHLTMARRGPAPAASRARTLAMAVAAWGASLLLGLLPALGWNCLGRLETCSTVLPLYAKAYVLFCVLAFLGILAAICALYARIYCQVRANARRLRAGPGSRRATSSSRSRHTPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARACPVLLQADPFLGLAMANSLLNPIIYTFTNRDLRHALLRLLCCGRGPCNQDSSNSLQRSPSAAGPSGGGLRRCLPPTLDRSSSPSEHLSPQQDGVDTSCSTGSPGVATANRSLVPTATD
uniprot
proteins
function
FUNCTION: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G proteins (By similarity). S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. S1P activation on O4-positive pre-oligodendrocytes induces process retraction via a Rho kinase/collapsin response-mediated protein signaling pathway. The S1P-induced survival of mature oligodendrocytes is mediated through a pertussis toxin-sensitive, Akt-dependent pathway. S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. These effects depend on the developmental stage of the cell. {ECO:0000250, ECO:0000269|PubMed:15703400}.
uniprot
proteins
mass_dalton
42331
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11705398
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15703400
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 42..62; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 69..89; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 112..132; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 152..172; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 193..213; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 254..274; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 289..309; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins