Ss18l1
entrez
192352
canonical
uniprot
Q91XJ0
canonical
ensembl
ENSRNOG00000060010
resolver
ensp
ENSRNOP00000080662
resolver
enst
ENSRNOT00000111398
resolver
genesymbol
Ss18l1
resolver
genesymbol_syn
Crest
resolver
uniprot
A0A8I5ZQS4
resolver
uniprot_entry
A0A8I5ZQS4_RAT
resolver
uniprot_entry
CREST_RAT
resolver
amino_acid_sequence
MSVAFASARPRGKGEVTQQTIQKMLDENHHLIQCILDYQSKGKTAECTQYQQILHRNLVYLATIADSNQNMQSLLPAPPTQNMNLGPGALSQSGSSQGLHPQGSLSDTVSTGLPPASLMQGQIGNGPNHVSMQQTAQSTLPTTSMSMSGSGHGTGPGYSHSGPTSQSVPMQGQGAISNYVSRTNINMQSNPVSMMHQQAARPTTTQRRVEASITRARRPLHDGPGWQGGSMMGQRPMAPYRPSQQGSSQQYLGQEEYYSEQYSHSQGSAEPMSQQYYPDGHSDYAYQQSSYTEQSYDRSFEDPTQHYYEGGNSQYSQQQAGYQQGTAQQQTYSQQQYPNQQSYPGQQQGYGPAQGAPSQYSGYQQGQGQQYGSYRTSQTGPSAQQQRPYGYEQGQYGNYQQ
uniprot
proteins
function
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. {ECO:0000269|PubMed:14716005, ECO:0000269|PubMed:15866867, ECO:0000269|PubMed:19081374}.
uniprot
proteins
mass_dalton
43999
uniprot
proteins
protein_family
SS18 family
uniprot
proteins
pubmed
14716005
uniprot
proteins
pubmed
15488321
uniprot
proteins
pubmed
15866867
uniprot
proteins
pubmed
19081374
uniprot
proteins
sequence_length
401
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14716005, ECO:0000269|PubMed:15488321, ECO:0000269|PubMed:15866867}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity). {ECO:0000250}.
uniprot
proteins