Txn
entrez
116484
canonical
uniprot
P11232
canonical
ensembl
ENSRNOG00055017982
resolver
ensembl
ENSRNOG00060010942
resolver
ensembl
ENSRNOG00065015992
resolver
ensp
ENSRNOP00055024517
resolver
ensp
ENSRNOP00060014400
resolver
ensp
ENSRNOP00065020862
resolver
enst
ENSRNOT00055030463
resolver
enst
ENSRNOT00060018517
resolver
enst
ENSRNOT00065026589
resolver
genesymbol
Txn
resolver
genesymbol_syn
Txn1
resolver
uniprot_entry
THIO_RAT
resolver
amino_acid_sequence
MVKLIESKEAFQEALAAAGDKLVVVDFSATWCGPCKMIKPFFHSLCDKYSNVVFLEVDVDDCQDVAADCEVKCMPTFQFYKKGQKVGEFSGANKEKLEATITEFA
uniprot
proteins
function
FUNCTION: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
11673
uniprot
proteins
post_translational_modification
PTM: In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Thioredoxin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2734107
uniprot
proteins
pubmed
7818492
uniprot
proteins
sequence_length
105
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P10599}. Cytoplasm {ECO:0000250|UniProtKB:P10599}. Secreted {ECO:0000250|UniProtKB:P10599}. Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA). Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus. Secreted by a leaderless secretory pathway. {ECO:0000250|UniProtKB:P10599}.
uniprot
proteins