RAB27B
entrez
5874
canonical
uniprot
O00194
canonical
ensembl
ENSG00000041353
resolver
ensp
ENSP00000262094
resolver
ensp
ENSP00000565909
resolver
ensp
ENSP00000632520
resolver
ensp
ENSP00000632521
resolver
ensp
ENSP00000632522
resolver
enst
ENST00000262094
resolver
enst
ENST00000895850
resolver
enst
ENST00000962461
resolver
enst
ENST00000962462
resolver
enst
ENST00000962463
resolver
genesymbol
RAB27B
resolver
hgnc
HGNC:9767
resolver
uniprot
B2RAB0
resolver
uniprot
Q9BZB6
resolver
uniprot_entry
RB27B_HUMAN
resolver
uniprot_sec
B2RAB0
resolver
uniprot_sec
Q9BZB6
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including DENND10, which promote the exchange of bound GDP for free GTP (Probable). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000305, ECO:0000305|PubMed:30771381}.
uniprot
proteins
amino_acid_sequence
MTDGDYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYNAQGPNGSSGKAFKVHLQLWDTAGQERFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCENPDIVLIGNKADLPDQREVNERQARELADKYGIPYFETSAATGQNVEKAVETLLDLIMKRMEQCVEKTQIPDTVNGGNSGNLDGEKPPEKKCIC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21775604, PubMed:30771381). RAB27B regulates homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity). {ECO:0000250|UniProtKB:Q8HZJ5, ECO:0000269|PubMed:21775604, ECO:0000269|PubMed:30771381}.
uniprot
proteins
mass_dalton
24608
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="T->N: GDP-locked. Increases interaction with DENND10. Disrupts late endocytic pathway homeostasis."; /evidence="ECO:0000269|PubMed:30771381"; MUTAGEN 78; /note="Q->L: GTP-locked. decreases interaction with DENND10."; /evidence="ECO:0000269|PubMed:30771381
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11178108
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21775604
uniprot
proteins
pubmed
2507536
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30771381
uniprot
proteins
pubmed
9066979
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Lipid-anchor. Late endosome {ECO:0000269|PubMed:30771381}.
uniprot
proteins