RAB3B
entrez
5865
canonical
uniprot
P20337
canonical
ensembl
ENSG00000169213
resolver
ensp
ENSP00000360718
resolver
ensp
ENSP00000570254
resolver
ensp
ENSP00000592034
resolver
ensp
ENSP00000611665
resolver
ensp
ENSP00000611666
resolver
enst
ENST00000371655
resolver
enst
ENST00000900195
resolver
enst
ENST00000921975
resolver
enst
ENST00000941606
resolver
enst
ENST00000941607
resolver
genesymbol
RAB3B
resolver
hgnc
HGNC:9778
resolver
uniprot
Q5VUL2
resolver
uniprot
Q9BSI1
resolver
uniprot_entry
RAB3B_HUMAN
resolver
uniprot_sec
Q5VUL2
resolver
uniprot_sec
Q9BSI1
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation. {ECO:0000250|UniProtKB:P20336}.
uniprot
proteins
amino_acid_sequence
MASVTDGKTGVKDASDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWATQIKTYSWDNAQVILVGNKCDMEEERVVPTEKGQLLAEQLGFDFFEASAKENISVRQAFERLVDAICDKMSDSLDTDPSMLGSSKNTRLSDTPPLLQQNCSC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:35871249). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:35871249). {ECO:0000269|PubMed:35871249}.
uniprot
proteins
mass_dalton
24758
uniprot
proteins
mutagenesis
MUTAGEN 86; /note="T->A: Loss of phosphorylation. No effect on GDI2, CHM and CHML binding."; /evidence="ECO:0000269|PubMed:29125462"; MUTAGEN 86; /note="T->E: Phosphomimetic mutant. Loss of GDI2, CHM and CHML binding."; /evidence="ECO:0000269|PubMed:29125462
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitor GDI2. {ECO:0000269|PubMed:29125462}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
2501306
uniprot
proteins
pubmed
29125462
uniprot
proteins
pubmed
35871249
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000250|UniProtKB:Q9CZT8}. Note=Colocalizes with DRC4 in the Golgi apparatus. {ECO:0000250|UniProtKB:Q9CZT8}.
uniprot
proteins