Pkn1
entrez
29355
canonical
uniprot
Q63433
canonical
ensembl
ENSRNOG00000004131
resolver
ensembl
ENSRNOG00055007359
resolver
ensembl
ENSRNOG00060013266
resolver
ensembl
ENSRNOG00065009743
resolver
ensp
ENSRNOP00000082261
resolver
ensp
ENSRNOP00000086181
resolver
ensp
ENSRNOP00055009754
resolver
ensp
ENSRNOP00060017974
resolver
ensp
ENSRNOP00065011871
resolver
enst
ENSRNOT00000106468
resolver
enst
ENSRNOT00000116583
resolver
enst
ENSRNOT00055012303
resolver
enst
ENSRNOT00060022720
resolver
enst
ENSRNOT00065015702
resolver
genesymbol
Pkn1
resolver
genesymbol_syn
Pkn
resolver
genesymbol_syn
Prk1
resolver
genesymbol_syn
Prkcl1
resolver
uniprot
A0A8I6G981
resolver
uniprot
A0A8I6GEN7
resolver
uniprot
Q6P748
resolver
uniprot
Q8VIJ2
resolver
uniprot_entry
A0A8I6G981_RAT
resolver
uniprot_entry
PKN1_RAT
resolver
uniprot_sec
A0A8I6GEN7
resolver
uniprot_sec
Q6P748
resolver
uniprot_sec
Q8VIJ2
resolver
activity_regulation
ACTIVITY REGULATION: Kinase activity is activated upon binding to Rho proteins (RHOA, RHOB and RAC1). Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids. Activated by caspase-3 (CASP3) cleavage during apoptosis. Two specific sites, Thr-778 (activation loop of the kinase domain) and Ser-920 (turn motif), need to be phosphorylated for its full activation (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MAGDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLKREIRKELKLKEGAENLRRATTDLGRSLAPVELLLRGSARRLDLLHQQLQELHAHVVLPDPTAGSDAPQSLAEGSPVCSSTNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQALQAGQLESQAAPDEAHGDPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLRESLERRLGELPADHPKGRLLREELTAASSAAFSAILPGPFPATHYSTLSKPAPLTGTLEVRVVGCKNLPETIPWSPPPSVGASGTPDSRTPFLSRPARGLYNRSGSLSGRSSLKGEAENSTEVSTVLKLDNTVVGQTAWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPIIERIPRLQRQKKIFSKQQGQTFQRARQMNIDVATWVRLLRRLIPNAVATGSFSPNASPGSEIRSTGDISMEKLNLGADSDSSSQKSPAGLPSTSCSLSSPTHESTTSPELPSETQETPGPGLCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFHSSGELFAIKALKKGDIVARDEVESLMCEKRILATVTRAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAVFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSTERDAEDVKKQPFFRTLDWDALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFRDFDFVAGGY
uniprot
proteins
ec_number
2.7.11.13
uniprot
proteins
function
FUNCTION: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation (PubMed:15375078, PubMed:8051089). Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14 (By similarity). Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro (By similarity). {ECO:0000250|UniProtKB:Q16512, ECO:0000269|PubMed:15375078, ECO:0000269|PubMed:8051089}.
uniprot
proteins
mass_dalton
104468
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated; preferably on serine. Phosphorylated during mitosis. {ECO:0000250|UniProtKB:Q16512}.; PTM: Activated by limited proteolysis with trypsin. {ECO:0000250}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
PKC subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15375078
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8051089
uniprot
proteins
pubmed
8135837
uniprot
proteins
pubmed
8943281
uniprot
proteins
sequence_length
946
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15375078}. Nucleus {ECO:0000250|UniProtKB:Q16512}. Endosome {ECO:0000250|UniProtKB:Q16512}. Cell membrane {ECO:0000269|PubMed:15375078}; Peripheral membrane protein {ECO:0000269|PubMed:15375078}. Cleavage furrow {ECO:0000250|UniProtKB:Q16512}. Midbody {ECO:0000250|UniProtKB:Q16512}. Note=Associates with chromatin in a ligand-dependent manner (By similarity). Localization to endosomes is mediated via its interaction with RHOB. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis (By similarity). Association to the cell membrane is dependent on Ser-377 phosphorylation. {ECO:0000250|UniProtKB:Q16512, ECO:0000269|PubMed:15375078}.
uniprot
proteins