Azi2
entrez
316051
canonical
uniprot
Q4KMA0
canonical
ensembl
ENSRNOG00000010096
resolver
ensp
ENSRNOP00000013449
resolver
enst
ENSRNOT00000013450
resolver
genesymbol
Azi2
resolver
uniprot
F1LQL4
resolver
uniprot_entry
AZI2_RAT
resolver
uniprot_entry
F1LQL4_RAT
resolver
amino_acid_sequence
MDTLVEDDICILNHEKAHKREAVTPLSAYPGDESVASHFALVTAYEDIKKRLKDSEKENSFLKKRIRALEEKLVGARVEEETSSVGREQVNKAYHAYREVCIDRDNLKSRLEKISKDNSESLRALTEQLQCKEVELLQLRTEVETQQVMRNLNPPSSNWEVEKLSCDLKIHGLEQELELLRKECSDLRTELQKARQTGPSQEDILQDRDVIRPSLPREEHVPHQGPHHSDHMQHAYWELRREMANLHLVTRVQAELLRQLKTAAAGKACTQVGCVEDLGRDSAKLHLANCTAAYKRHPPLSPHGKATCYAPPSTLPGDRKAFSDKAVLQSWTDNERLTPNDGADFQEHNSYGRNSLEDNSWVFPSPPKSSETAFGESKSKILPSPNLPPLHYLDQHNQNCLYKS
uniprot
proteins
function
FUNCTION: Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9H6S1}.
uniprot
proteins
mass_dalton
45986
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated via 'Lys-48'-linked polyubiquitination by TRIM38, leading to its degradation. {ECO:0000250|UniProtKB:Q9QYP6}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
404
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H6S1}.
uniprot
proteins