PPP1R11
entrez
6992
canonical
uniprot
O60927
canonical
ensembl
ENSG00000204619
resolver
ensembl
ENSG00000206501
resolver
ensembl
ENSG00000227720
resolver
ensembl
ENSG00000233314
resolver
ensembl
ENSG00000234058
resolver
ensembl
ENSG00000236560
resolver
ensembl
ENSG00000237403
resolver
ensembl
ENSG00000237829
resolver
ensp
ENSP00000365963
resolver
ensp
ENSP00000373107
resolver
ensp
ENSP00000394056
resolver
ensp
ENSP00000403557
resolver
ensp
ENSP00000407981
resolver
ensp
ENSP00000411038
resolver
ensp
ENSP00000412297
resolver
ensp
ENSP00000414808
resolver
enst
ENST00000376772
resolver
enst
ENST00000383612
resolver
enst
ENST00000431424
resolver
enst
ENST00000431977
resolver
enst
ENST00000436591
resolver
enst
ENST00000437937
resolver
enst
ENST00000448378
resolver
enst
ENST00000452679
resolver
genesymbol
PPP1R11
resolver
genesymbol_syn
HCGV
resolver
genesymbol_syn
TCTE5
resolver
hgnc
HGNC:9285
resolver
uniprot
A2BEK1
resolver
uniprot_entry
A2BEK1_HUMAN
resolver
uniprot_entry
PP1RB_HUMAN
resolver
amino_acid_sequence
MAEAGAGLSETVTETTVTVTTEPENRSLTIKLRKRKPEKKVEWTSDTVDNEHMGRRSSKCCCIYEKPRAFGESSTESDEEEEEGCGHTHCVRGHRKGRRRATLGPTPTTPPQPPDPSQPPPGPMQH
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442). {ECO:0000269|PubMed:27805901, ECO:0000269|PubMed:9843442}.
uniprot
proteins
mass_dalton
13953
uniprot
proteins
mutagenesis
MUTAGEN 52; /note="H->A: Loss of function in inducing TLR2 degradation."; /evidence="ECO:0000269|PubMed:27805901"; MUTAGEN 60..62; /note="CCC->SSS: Loss of function in inducing TLR2 degradation."; /evidence="ECO:0000269|PubMed:27805901"; MUTAGEN 85; /note="C->S: Loss of function in inducing TLR2 degradation."; /evidence="ECO:0000269|PubMed:27805901"; MUTAGEN 87; /note="H->A: Loss of function in inducing TLR2 degradation."; /evidence="ECO:0000269|PubMed:27805901"; MUTAGEN 89..90; /note="HC->AS: Loss of function in inducing TLR2 degradation."; /evidence="ECO:0000269|PubMed:27805901"; MUTAGEN 94; /note="H->A: Loss of function in inducing TLR2 degradation."; /evidence="ECO:0000269|PubMed:27805901
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000269|PubMed:27805901}.
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27805901
uniprot
proteins
pubmed
8781118
uniprot
proteins
pubmed
8938444
uniprot
proteins
pubmed
9843442
uniprot
proteins
sequence_length
126
uniprot
proteins