Tnfrsf1a
entrez
21937
canonical
uniprot
P25118
canonical
ensembl
ENSMUSG00000030341
resolver
ensp
ENSMUSP00000032491
resolver
enst
ENSMUST00000032491
resolver
genesymbol
Tnfrsf1a
resolver
genesymbol_syn
Tnfr-1
resolver
genesymbol_syn
Tnfr1
resolver
uniprot
Q3U479
resolver
uniprot_entry
Q3U479_MOUSE
resolver
uniprot_entry
TNR1A_MOUSE
resolver
amino_acid_sequence
MGLPTVPGLLLSLVLLALLMGIHPSGVTGLVPSLGDREKRDSLCPQGKYVHSKNNSICCTKCHKGTYLVSDCPSPGRDTVCRECEKGTFTASQNYLRQCLSCKTCRKEMSQVEISPCQADKDTVCGCKENQFQRYLSETHFQCVDCSPCFNGTVTIPCKETQNTVCNCHAGFFLRESECVPCSHCKKNEECMKLCLPPPLANVTNPQDSGTAVLLPLVILLGLCLLSFIFISLMCRYPRWRPEVYSIICRDPVPVKEEKAGKPLTPAPSPAFSPTSGFNPTLGFSTPGFSSPVSSTPISPIFGPSNWHFMPPVSEVVPTQGADPLLYESLCSVPAPTSVQKWEDSAHPQRPDNADLAILYAVVDGVPPARWKEFMRFMGLSEHEIERLEMQNGRCLREAQYSMLEAWRRRTPRHEDTLEVVGLVLSKMNLAGCLENILEALRNPAPSSTTRLPR
uniprot
proteins
function
FUNCTION: Receptor for TNFSF2/TNF and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
50130
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Glycosylated at Arg-376 by S.typhimurium protein Ssek3: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions. {ECO:0000269|PubMed:30902834}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1645445
uniprot
proteins
pubmed
1647956
uniprot
proteins
pubmed
1657766
uniprot
proteins
pubmed
1849278
uniprot
proteins
pubmed
24440909
uniprot
proteins
pubmed
30902834
uniprot
proteins
pubmed
8188324
uniprot
proteins
pubmed
8381516
uniprot
proteins
sequence_length
454
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 213..235; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins