DOC2B
entrez
8447
canonical
uniprot
Q14184
canonical
ensembl
ENSG00000272636
resolver
ensp
ENSP00000482950
resolver
ensp
ENSP00000600587
resolver
enst
ENST00000613549
resolver
genesymbol
DOC2B
resolver
genesymbol_syn
DOC2BL
resolver
hgnc
HGNC:2986
resolver
uniprot
A0A087WZX8
resolver
uniprot_entry
DOC2B_HUMAN
resolver
uniprot_sec
A0A087WZX8
resolver
amino_acid_sequence
MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSELPGAVLSD
uniprot
proteins
function
FUNCTION: Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:9804756}.
uniprot
proteins
mass_dalton
45922
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17548353
uniprot
proteins
pubmed
21220648
uniprot
proteins
pubmed
8554557
uniprot
proteins
pubmed
9804756
uniprot
proteins
sequence_length
412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic granule {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates to the plasma membrane in a calcium-dependent manner. {ECO:0000250}.
uniprot
proteins