Psmb2
entrez
29675
canonical
uniprot
P40307
canonical
ensembl
ENSRNOG00000011463
resolver
ensembl
ENSRNOG00055013855
resolver
ensembl
ENSRNOG00060015270
resolver
ensembl
ENSRNOG00065030659
resolver
ensp
ENSRNOP00000015618
resolver
ensp
ENSRNOP00055019427
resolver
ensp
ENSRNOP00060020949
resolver
ensp
ENSRNOP00065043409
resolver
enst
ENSRNOT00000015618
resolver
enst
ENSRNOT00055023827
resolver
enst
ENSRNOT00060026177
resolver
enst
ENSRNOT00065052837
resolver
genesymbol
Psmb2
resolver
uniprot_entry
PSB2_RAT
resolver
amino_acid_sequence
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRVIDKDGIHNLENITFTKRSS
uniprot
proteins
function
FUNCTION: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000250|UniProtKB:P49721}.
uniprot
proteins
mass_dalton
22912
uniprot
proteins
protein_family
Peptidase T1B family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16988215
uniprot
proteins
pubmed
8405448
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P49721}. Nucleus {ECO:0000250|UniProtKB:P49721}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000250|UniProtKB:P49721}.
uniprot
proteins