RRAGB
entrez
10325
canonical
uniprot
Q5VZM2
canonical
ensembl
ENSG00000083750
resolver
ensp
ENSP00000262850
resolver
ensp
ENSP00000364077
resolver
ensp
ENSP00000700015
resolver
ensp
ENSP00000700020
resolver
genesymbol
RRAGB
resolver
hgnc
HGNC:19901
resolver
uniprot
A8K042
resolver
uniprot
Q15348
resolver
uniprot
Q8N3T0
resolver
uniprot_entry
RRAGB_HUMAN
resolver
uniprot_sec
A8K042
resolver
uniprot_sec
Q15348
resolver
uniprot_sec
Q8N3T0
resolver
activity_regulation
ACTIVITY REGULATION: The activation of GTP-binding proteins is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (PubMed:22980980, PubMed:23723238). The Ragulator complex functions as a GEF and promotes the active GTP-bound form (PubMed:22980980). The GATOR1 complex functions as a GAP and stimulates RRAGB GTPase activity to turn it into its inactive GDP-bound form, preventing mTORC1 recruitment and activation (PubMed:23723238). {ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:23723238}.
uniprot
proteins
amino_acid_sequence
MEESDSEKTTEKENLGPRMDPPLGEPEGSLGWVLPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATILDRIHSLQINSSLSTYSLVDSVGNTKTFDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAEIIEADEVLLFERATFLVISHYQCKEQRDAHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKQCLLMR
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:18497260, PubMed:20381137, PubMed:23723238, PubMed:24095279). Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagB/RRAGB is in its active form when GTP-bound RagB/RRAGB forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagB/RRAGB heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD) (PubMed:18497260, PubMed:20381137, PubMed:23723238, PubMed:24095279). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:18497260, PubMed:20381137, PubMed:23723238). Involved in the RCC1/Ran-GTPase pathway (PubMed:9394008). {ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:9394008}.
uniprot
proteins
mass_dalton
43250
uniprot
proteins
mutagenesis
MUTAGEN 54; /note="T->L: Decreased RPTOR-binding."; /evidence="ECO:0000269|PubMed:18497260"; MUTAGEN 54; /note="T->N: Reduced affinity for all nucleotides, but with preferential binding of GDP over GTP."; /evidence="ECO:0000269|PubMed:24095279"; MUTAGEN 127; /note="Q->L: Maintains GTP-bound state. Increased RPTOR-binding."; /evidence="ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:24095279
uniprot
proteins
protein_family
GTR/RAG GTP-binding protein family
uniprot
proteins
pubmed
11073942
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18497260
uniprot
proteins
pubmed
20381137
uniprot
proteins
pubmed
22575674
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22980980
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23723238
uniprot
proteins
pubmed
24095279
uniprot
proteins
pubmed
25259925
uniprot
proteins
pubmed
25561175
uniprot
proteins
pubmed
25567906
uniprot
proteins
pubmed
7499430
uniprot
proteins
pubmed
9394008
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9394008}. Lysosome membrane {ECO:0000269|PubMed:20381137}. Note=Recruited to the lysosome surface by the Ragulator complex. {ECO:0000269|PubMed:20381137}.
uniprot
proteins