Ttyh2
entrez
117160
canonical
uniprot
Q3TH73
canonical
ensembl
ENSMUSG00000034714
resolver
ensp
ENSMUSP00000037821
resolver
genesymbol
Ttyh2
resolver
uniprot
Q3U103
resolver
uniprot
Q3U8L3
resolver
uniprot
Q6P9J3
resolver
uniprot
Q920A8
resolver
uniprot_entry
TTYH2_MOUSE
resolver
uniprot_sec
Q3U103
resolver
uniprot_sec
Q3U8L3
resolver
uniprot_sec
Q6P9J3
resolver
uniprot_sec
Q920A8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by (4-[(2-butyl-6,7-dichloro-2- cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid). {ECO:0000269|PubMed:31138989}.
uniprot
proteins
amino_acid_sequence
MPAARVEYIAPWWVVWLHSVPHLGLRLQRVDSTFSPGDETYQESLLFLGVLAAIGLGLNLIFLTVYLVCTCCCRRDHTVQTKQQESCCVTWTAVVAGLLCCAAVGVGFYGNSETNDGMHQLIYSLDNANHTFSGMDELVSANTQRMKVDLEQHLARLSEIIAARGDYIQTLKFMQQMAGNVVSQLSGLPVWREVTTQLTKLSHQTAYVEYYRWLSYLLLFILDLVICLVTCLGLARRSKCLLASMLCCGILTLILSWASLAADAAAAVGTSDFCMAPDIYILNNTGSQINSEVTRYYLHCSQSLISPFQQSLTTFQRSLTTMQIQVGGLLQFAVPLFPTAEKDLLGIQLLLNNSEISLHQLTAMLDCRGLHKDYLDALTGICYDGIEGLLFLGLFSLLAALAFSTLTCAGPRAWKYFINRDRDYDDIDDDDPFNPQARRIAAHNPTRGQLHSFCSYSSGLGSQCSLQPPSQTISNAPVSEYMNQAILFGGNPRYENVPLIGRGSPPPTYSPSMRPTYMSVADEHLRHYEFPS
uniprot
proteins
function
FUNCTION: Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate (PubMed:31138989). Probable large-conductance Ca(2+)-activated chloride channel (By similarity). {ECO:0000250|UniProtKB:Q9BSA4, ECO:0000269|PubMed:31138989}.
uniprot
proteins
mass_dalton
59008
uniprot
proteins
mutagenesis
MUTAGEN 164; /note="R->A: Significant decrease in hypo-osmotic solution-induced chloride conductance but no effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:31138989
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by NEDD4L, leading to its proteasomal degradation. {ECO:0000250|UniProtKB:Q7ZWN9}.
uniprot
proteins
protein_family
Tweety family
uniprot
proteins
pubmed
11597145
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31138989
uniprot
proteins
pubmed
34824283
uniprot
proteins
sequence_length
532
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31138989}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..65; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 386..406; /note="Helical; Name=5"; /evidence="ECO:0000255
uniprot
proteins