CLEC6A
entrez
93978
canonical
uniprot
Q6EIG7
canonical
ensembl
ENSG00000205846
resolver
ensp
ENSP00000371505
resolver
genesymbol
CLEC6A
resolver
genesymbol_syn
CLECSF10
resolver
genesymbol_syn
DECTIN2
resolver
hgnc
HGNC:14556
resolver
uniprot
A2RUK3
resolver
uniprot_entry
CLC6A_HUMAN
resolver
uniprot_sec
A2RUK3
resolver
amino_acid_sequence
MMQEQQPQSTEKRGWLSLRLWSVAGISIALLSACFIVSCVVTYHFTYGETGKRLSELHSYHSSLTCFSEGTKVPAWGCCPASWKSFGSSCYFISSEEKVWSKSEQNCVEMGAHLVVFNTEAEQNFIVQQLNESFSYFLGLSDPQGNNNWQWIDKTPYEKNVRFWHLGEPNHSAEQCASIVFWKPTGWGWNDVICETRRNSICEMNKIYL
uniprot
proteins
function
FUNCTION: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed:23911656, PubMed:28652405). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (By similarity). Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity). {ECO:0000250|UniProtKB:Q9JKF4, ECO:0000269|PubMed:23911656, ECO:0000269|PubMed:28652405}.
uniprot
proteins
mass_dalton
23998
uniprot
proteins
pubmed
15175046
uniprot
proteins
pubmed
15368084
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15810886
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
23911656
uniprot
proteins
pubmed
28652405
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23911656}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins