Chrm2
entrez
81645
canonical
uniprot
P10980
canonical
ensembl
ENSRNOG00000046972
resolver
ensembl
ENSRNOG00055031939
resolver
ensp
ENSRNOP00000065178
resolver
ensp
ENSRNOP00000082007
resolver
ensp
ENSRNOP00000088860
resolver
ensp
ENSRNOP00000095668
resolver
ensp
ENSRNOP00000100188
resolver
ensp
ENSRNOP00000108301
resolver
ensp
ENSRNOP00055045647
resolver
ensp
ENSRNOP00055045649
resolver
ensp
ENSRNOP00055045653
resolver
ensp
ENSRNOP00055045654
resolver
enst
ENSRNOT00000075341
resolver
enst
ENSRNOT00000115807
resolver
enst
ENSRNOT00000118028
resolver
enst
ENSRNOT00000118281
resolver
enst
ENSRNOT00000132051
resolver
enst
ENSRNOT00000161169
resolver
enst
ENSRNOT00055055265
resolver
enst
ENSRNOT00055055268
resolver
enst
ENSRNOT00055055273
resolver
enst
ENSRNOT00055055276
resolver
genesymbol
Chrm2
resolver
genesymbol_syn
Chrm-2
resolver
uniprot
Q9Z2Z1
resolver
uniprot_entry
ACM2_RAT
resolver
uniprot_sec
Q9Z2Z1
resolver
amino_acid_sequence
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
uniprot
proteins
function
FUNCTION: Muscarinic receptor for acetylcholine, a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. CHRM2 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G proteins and mediates signaling by inhibiting adenylate cyclase activity. {ECO:0000250|UniProtKB:P08172}.
uniprot
proteins
mass_dalton
51539
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of the P-X-P-P motif promotes association with beta-arrestin (ARRB1 and/or ARRB2), leading to receptor desensitization and negative regulation of G protein-coupled receptor signaling. {ECO:0000250|UniProtKB:P08172}.
uniprot
proteins
protein_family
CHRM2 sub-subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Muscarinic acetylcholine receptor subfamily
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2825184
uniprot
proteins
pubmed
9972520
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08172}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08172}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P08172}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08172}. Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250|UniProtKB:P06199}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..46; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P08172"; TRANSMEM 61..85; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P08172"; TRANSMEM 93..119; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P08172"; TRANSMEM 141..162; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P08172"; TRANSMEM 183..207; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P08172"; TRANSMEM 388..412; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P08172"; TRANSMEM 420..442; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P08172
uniprot
proteins