Riok1
entrez
71340
canonical
uniprot
Q922Q2
canonical
ensembl
ENSMUSG00000021428
resolver
ensp
ENSMUSP00000021866
resolver
enst
ENSMUST00000021866
resolver
genesymbol
Riok1
resolver
uniprot
Q3U7D5
resolver
uniprot
Q99LZ1
resolver
uniprot
Q9CU84
resolver
uniprot
Q9CXN9
resolver
uniprot_entry
RIOK1_MOUSE
resolver
uniprot_sec
Q3U7D5
resolver
uniprot_sec
Q99LZ1
resolver
uniprot_sec
Q9CU84
resolver
uniprot_sec
Q9CXN9
resolver
amino_acid_sequence
MDCSLDRMASVVPGQFDDADSSDSENKELQPIHAEDGGVLLKSLQNAAAEVKGDAETDEEDDYDDDDDWYLDDATGKLTKGCTWNGGSNYQANRQTSNYNSAKMSTPIDKSLRKFENKINLNKLNVTDSVTNKVTVKLRQKEAESYRIKDKADRATVEQVLDPRTRMILFKLLHKDHISEIHGCISTGKEANVYYASTPSGESRAIKIYKTSILMFKDRDKYVTGEFRFRRGYCKGNPRKMVRTWAEKEMRNLCRLKTANIPCPEPIRLRSHVLLMGFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRKMYQDARLVHADLSEFNMLYHGGDVYIIDVSQSVEHDHPHALEFLRKDCTNVNDFFSKHAVAVMTVRELFDFVTDPSITADNMDAYLEKAMEIASQRTKEEKTSQDHVDEEVFKQAYIPRTLNEVKNYERDVDIMMRLKEEDMALNTQQDNILYQTVMGLKKDLSGVQKVPALLESEVKEETCFGSDDAGGSECSDTVSEEQEDQAGCRNHIADPDIDKKERKKMVKEAQREKRKNKIPKHVKKRKEKTAKAKKGK
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
function
FUNCTION: Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (By similarity). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (By similarity). {ECO:0000250|UniProtKB:G0S3J5, ECO:0000250|UniProtKB:Q12196, ECO:0000250|UniProtKB:Q9BRS2}.
uniprot
proteins
mass_dalton
64910
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
RIO-type Ser/Thr kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
567
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BRS2}.
uniprot
proteins