Tasl
entrez
71398
canonical
uniprot
Q9D3J9
canonical
ensembl
ENSMUSG00000025058
resolver
ensp
ENSMUSP00000109609
resolver
enst
ENSMUST00000113976
resolver
genesymbol
Tasl
resolver
genesymbol_syn
5430427O19Rik
resolver
uniprot
Q08EG0
resolver
uniprot_entry
Q08EG0_MOUSE
resolver
uniprot_entry
TASL_MOUSE
resolver
amino_acid_sequence
MLSEGYLSGLTYWNDIHWNCASYNEPVAGDQGKETSSVAALSYSSVDETQVQSLYVSCKSSGKFISSVHARASQHSRSQSRTVLQANSNPVFESPTLAAVGICRDVIRETYLVPPSCKSICKNYNDLHIAGGQVMAINSVMANFPSESSFEDGPLLKSSEISLSMEDSTSTQLTELPLKPIQRYSSYWRITSIKEKSSLQMQKPISNAVLNEYLEQKVVELYKQYIMDTVFHDSSPTQILASEFIMTNVDQISLQVSKEKNLDTSKVKDIVISHLLQLVSSEISTPSLHISQYSNITP
uniprot
proteins
function
FUNCTION: Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons. Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes. {ECO:0000250|UniProtKB:Q9HAI6}.
uniprot
proteins
mass_dalton
33057
uniprot
proteins
post_translational_modification
PTM: The phosphorylated pLxIS motif constitutes an IRF5-binding motif, leading to recruitment of the transcription factor IRF5 to induce type-I interferons and other cytokines. {ECO:0000250|UniProtKB:Q9HAI6}.
uniprot
proteins
protein_family
TASL protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
298
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9HAI6}. Endosome membrane {ECO:0000250|UniProtKB:Q9HAI6}. Nucleus {ECO:0000250|UniProtKB:Q9HAI6}. Cytoplasm {ECO:0000250|UniProtKB:Q9HAI6}. Note=Recruited to endolysosome following interaction with SLC15A4. May colocalize with TLR7 in the endosomal pathway. {ECO:0000250|UniProtKB:Q9HAI6}.
uniprot
proteins