MICAL1
entrez
64780
canonical
uniprot
Q8TDZ2
canonical
ensembl
ENSG00000135596
resolver
ensp
ENSP00000351385
resolver
ensp
ENSP00000351664
resolver
ensp
ENSP00000486901
resolver
genesymbol
MICAL1
resolver
genesymbol_syn
MICAL
resolver
genesymbol_syn
NICAL
resolver
hgnc
HGNC:20619
resolver
uniprot
B7Z3R5
resolver
uniprot
E1P5F0
resolver
uniprot
Q7Z633
resolver
uniprot
Q8IVS9
resolver
uniprot
Q96G47
resolver
uniprot
Q9H6X6
resolver
uniprot
Q9H7I0
resolver
uniprot
Q9HAA1
resolver
uniprot
Q9UFF7
resolver
uniprot_entry
MICA1_HUMAN
resolver
uniprot_sec
B7Z3R5
resolver
uniprot_sec
E1P5F0
resolver
uniprot_sec
Q7Z633
resolver
uniprot_sec
Q8IVS9
resolver
uniprot_sec
Q96G47
resolver
uniprot_sec
Q9H6X6
resolver
uniprot_sec
Q9H7I0
resolver
uniprot_sec
Q9HAA1
resolver
uniprot_sec
Q9UFF7
resolver
amino_acid_sequence
MASPTSTNPAHAHFESFLQAQLCQDVLSSFQELCGALGLEPGGGLPQYHKIKDQLNYWSAKSLWTKLDKRAGQPVYQQGRACTSTKCLVVGAGPCGLRVAVELALLGARVVLVEKRTKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVEIHWGVTFTGLQPPPRKGSGWRAQLQPNPPAQLANYEFDVLISAAGGKFVPEGFKVREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQSFFQSLLKATGIDLENIVYYKDDTHYFVMTAKKQCLLRLGVLRQDWPDTNRLLGSANVVPEALQRFTRAAADFATHGKLGKLEFAQDAHGQPDVSAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGAESLEVLAERESLYQLLSQTSPENMHRNVAQYGLDPATRYPNLNLRAVTPNQVRDLYDVLAKEPVQRNNDKTDTGMPATGSAGTQEELLRWCQEQTAGYPGVHVSDLSSSWADGLALCALVYRLQPGLLEPSELQGLGALEATAWALKVAENELGITPVVSAQAVVAGSDPLGLIAYLSHFHSAFKSMAHSPGPVSQASPGTSSAVLFLSKLQRTLQRSRAKENAEDAGGKKLRLEMEAETPSTEVPPDPEPGVPLTPPSQHQEAGAGDLCALCGEHLYVLERLCVNGHFFHRSCFRCHTCEATLWPGGYEQHPGDGHFYCLQHLPQTDHKAEGSDRGPESPELPTPSENSMPPGLSTPTASQEGAGPVPDPSQPTRRQIRLSSPERQRLSSLNLTPDPEMEPPPKPPRSCSALARHALESSFVGWGLPVQSPQALVAMEKEEKESPFSSEEEEEDVPLDSDVEQALQTFAKTSGTMNNYPTWRRTLLRRAKEEEMKRFCKAQTIQRRLNEIEAALRELEAEGVKLELALRRQSSSPEQQKKLWVGQLLQLVDKKNSLVAEEAELMITVQELNLEEKQWQLDQELRGYMNREENLKTAADRQAEDQVLRKLVDLVNQRDALIRFQEERRLSELALGTGAQG
uniprot
proteins
ec_number
1.14.13.225
uniprot
proteins
ec_number
1.6.3.1
uniprot
proteins
function
FUNCTION: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:29343822). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023, PubMed:29343822). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export (PubMed:32344433). {ECO:0000250|UniProtKB:Q8VDP3, ECO:0000269|PubMed:18305261, ECO:0000269|PubMed:21864500, ECO:0000269|PubMed:26845023, ECO:0000269|PubMed:28230050, ECO:0000269|PubMed:29343822, ECO:0000269|PubMed:32344433, ECO:0000305|PubMed:27552051}.
uniprot
proteins
mass_dalton
117875
uniprot
proteins
mutagenesis
MUTAGEN 91..96; /note="GAGPCG->WAWPCWL: Increased association with Rab8- Rab10- and GRAPHs-positive endosomal tubules. Decreased WDR44-positive endosomal tubules formation. Loss of E-cadherin and MMP14 export and decreased CFTR export."; /evidence="ECO:0000269|PubMed:32344433"; MUTAGEN 832; /note="K->A: Abolishes interaction with ARHGAP26 ANDARHGAP10."; /evidence="ECO:0000269|PubMed:32344433
uniprot
proteins
protein_family
Mical family
uniprot
proteins
pubmed
11214971
uniprot
proteins
pubmed
11827972
uniprot
proteins
pubmed
12110185
uniprot
proteins
pubmed
12788069
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15694364
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17043746
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17662518
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18305261
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21864500
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24440334
uniprot
proteins
pubmed
26845023
uniprot
proteins
pubmed
27552051
uniprot
proteins
pubmed
28230050
uniprot
proteins
pubmed
29343822
uniprot
proteins
pubmed
30905672
uniprot
proteins
pubmed
32344433
uniprot
proteins
sequence_length
1067
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32344433}. Cytoplasm, cytoskeleton. Endosome membrane {ECO:0000269|PubMed:32344433}. Midbody {ECO:0000269|PubMed:28230050}. Note=Accumulates transiently at the abscission site before abscission occurs. Colocalized with GRAF1/ARHGAP26 and GRAF2/ARHGAP10, RAB8A, RAB8B and RAB10 on endosomal tubules (PubMed:32344433). {ECO:0000269|PubMed:28230050, ECO:0000269|PubMed:32344433}.
uniprot
proteins