Mefv
entrez
58923
canonical
uniprot
Q9JJ25
canonical
ensembl
ENSRNOG00000008134
resolver
ensp
ENSRNOP00000070256
resolver
enst
ENSRNOT00000081191
resolver
genesymbol
Mefv
resolver
uniprot
A0A0G2JXG0
resolver
uniprot
A0A0G2JYG3
resolver
uniprot_entry
A0A0G2JXG0_RAT
resolver
uniprot_entry
MEFV_RAT
resolver
uniprot_sec
A0A0G2JYG3
resolver
amino_acid_sequence
MANTRVDHLLNTLEELLPYELEKFKFKLHTTSLEKGHSRIPLSLVKMARPIKLTRLLLTYYGEEYAVRLTLQILRATNQRQLAEELHKATGPEHLTEENGVGGSVQSSAENKDKGVKGSDVPGEDEAQQNDDESDILPPIQAEVGKGPQKKSLAKRKDQRGPESLDSQTKPGARSAAPLYRRTLVTQSPGDKENRAGAQPQECQLCREAARSTAMSQGGERSRRLKCICLQERSDPGVLKLPLTQKKENPQIQKLFRLKRKQEMAVSFVREATLNGRTTGTLEKGVGIPEHSMMLDEETSRNMSSKISLTREKRCTASWTENGNGGPETPETLGETVSSILCDSCSPKVLLSLGEKLAQTPEDPASLGQAASKGRSRDKVACPLCHTQGELPAKACVQSSCSCSVAPGDPKASGRHSICFQCQSSRAGKSCEAQSPQFLPQCPRHMKQVQLLFCEDHREPICLICRLSQEHQGHRVRPIEEAALQYKEQIRKQLERLREMRGYVEEHKLPADKKAEDFLKQTETQKQRISCPLEKLFQFLEQQEQLFVTWLQELVQTIGKVRETYYTQVSLLDKLIGELEAKQDQPEWELMQDIGATLHRAETMTASELLGIPPGVKEKLHLLYQKSKSAEKNMQRFSEMLGSEMAFSASDVATREGCRPSTTKAQALIPTVHLKCDGAHTQDFDVILCAELEAGGSEPQDYLHPSSAQDTPELHEIHSQNNKRKFKSFLKWKPSFSRTDRCLRTCW
uniprot
proteins
function
FUNCTION: Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (By similarity). Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity). It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (By similarity). {ECO:0000250|UniProtKB:O15553, ECO:0000250|UniProtKB:Q9JJ26}.
uniprot
proteins
mass_dalton
83743
uniprot
proteins
post_translational_modification
PTM: Degraded along with the delivery of its substrates to autolysosomal compartments (at protein level). {ECO:0000250|UniProtKB:O15553}.
uniprot
proteins
pubmed
10818206
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
747
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O15553}. Cell projection, ruffle {ECO:0000250|UniProtKB:O15553}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O15553}. Cytoplasm {ECO:0000250|UniProtKB:O15553}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:O15553}. Nucleus {ECO:0000250|UniProtKB:O15553}. Note=Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles. In pre-apoptotic cells, colocalizes with PYCARD/ASC in large specks (pyroptosomes). In migrating monocytes, strongly polarized at the leading edge of the cell where it colocalizes with polymerizing actin and PYCARD/ASC (By similarity). {ECO:0000250|UniProtKB:O15553}.
uniprot
proteins