RAD51B
entrez
5890
canonical
uniprot
O15315
canonical
ensembl
ENSG00000182185
resolver
ensp
ENSP00000418859
resolver
ensp
ENSP00000419471
resolver
ensp
ENSP00000419881
resolver
ensp
ENSP00000420061
resolver
ensp
ENSP00000518559
resolver
enst
ENST00000487861
resolver
genesymbol
RAD51B
resolver
genesymbol_syn
RAD51L1
resolver
genesymbol_syn
REC2
resolver
hgnc
HGNC:9822
resolver
uniprot
C9JYJ0
resolver
uniprot
O60914
resolver
uniprot
O75210
resolver
uniprot
Q3Y4F8
resolver
uniprot
Q6FHX8
resolver
uniprot
Q86SY3
resolver
uniprot
Q86SY4
resolver
uniprot
Q86TR0
resolver
uniprot
Q86U92
resolver
uniprot
Q86U93
resolver
uniprot
Q86U94
resolver
uniprot
Q8N6H4
resolver
uniprot
Q9UPL5
resolver
uniprot_entry
C9JYJ0_HUMAN
resolver
uniprot_entry
RA51B_HUMAN
resolver
uniprot_sec
O60914
resolver
uniprot_sec
O75210
resolver
uniprot_sec
Q3Y4F8
resolver
uniprot_sec
Q6FHX8
resolver
uniprot_sec
Q86SY3
resolver
uniprot_sec
Q86SY4
resolver
uniprot_sec
Q86TR0
resolver
uniprot_sec
Q86U92
resolver
uniprot_sec
Q86U93
resolver
uniprot_sec
Q86U94
resolver
uniprot_sec
Q8N6H4
resolver
uniprot_sec
Q9UPL5
resolver
amino_acid_sequence
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSVTQAELNWAPEILPPQPPEQLGLQMCHHTQLIF
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving RAD51B is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with HMGA1. {ECO:0000269|PubMed:11978964}.; DISEASE: Note=A chromosomal aberration involving RAD51B is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with HMGA2. {ECO:0000269|PubMed:12649198, ECO:0000269|PubMed:9892177}.
uniprot
proteins
function
FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11751636, ECO:0000269|PubMed:11842113, ECO:0000269|PubMed:12441335, ECO:0000269|PubMed:23108668, ECO:0000269|PubMed:23149936}.
uniprot
proteins
mass_dalton
42196
uniprot
proteins
mutagenesis
MUTAGEN 326; /note="P->L: Abolishes interaction with BCR-ABLSH3 domain."; /evidence="ECO:0000269|PubMed:19657362
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by BCR-ABL. {ECO:0000269|PubMed:19657362}.
uniprot
proteins
protein_family
RAD51 subfamily
uniprot
proteins
protein_family
RecA family
uniprot
proteins
pubmed
11744692
uniprot
proteins
pubmed
11751635
uniprot
proteins
pubmed
11751636
uniprot
proteins
pubmed
11842112
uniprot
proteins
pubmed
11842113
uniprot
proteins
pubmed
11978964
uniprot
proteins
pubmed
12427746
uniprot
proteins
pubmed
12441335
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12649198
uniprot
proteins
pubmed
14704354
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19657362
uniprot
proteins
pubmed
20207730
uniprot
proteins
pubmed
21965664
uniprot
proteins
pubmed
23108668
uniprot
proteins
pubmed
23149936
uniprot
proteins
pubmed
24005041
uniprot
proteins
pubmed
9207106
uniprot
proteins
pubmed
9441753
uniprot
proteins
pubmed
9512535
uniprot
proteins
pubmed
9892177
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins