NTAN1
entrez
123803
canonical
uniprot
Q96AB6
canonical
ensembl
ENSG00000157045
resolver
ensembl
ENSG00000275779
resolver
ensp
ENSP00000287706
resolver
ensp
ENSP00000481975
resolver
ensp
ENSP00000483643
resolver
ensp
ENSP00000484380
resolver
ensp
ENSP00000485340
resolver
enst
ENST00000287706
resolver
enst
ENST00000614882
resolver
enst
ENST00000620176
resolver
enst
ENST00000622833
resolver
enst
ENST00000624579
resolver
genesymbol
NTAN1
resolver
hgnc
HGNC:29909
resolver
uniprot
A0A087X0T5
resolver
uniprot
Q7Z4Z0
resolver
uniprot_entry
A0A087X0T5_HUMAN
resolver
uniprot_entry
NTAN1_HUMAN
resolver
uniprot_sec
Q7Z4Z0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by micromolar concentrations of copper and zinc ions. {ECO:0000269|PubMed:21375249}.
uniprot
proteins
amino_acid_sequence
MPLLVEGRRVRLPQSAGDLVRAHPPLEERARLLRGQSVQQVGPQGLLYVQQRELAVTSPKDGSISILGSDDATTCHIVVLRHTGNGATCLTHCDGTDTKAEVPLIMNSIKSFSDHAQCGRLEVHLVGGFSDDRQLSQKLTHQLLSEFDRQEDDIHLVTLCVTELNDREENENHFPVIYGIAVNIKTAEIYRASFQDRGPEEQLRAARTLAGGPMISIYDAETEQLRIGPYSWTPFPHVDFWLHQDDKQILENLSTSPLAEPPHFVEHIRSTLMFLKKHPSPAHTLFSGNKALLYKKNEDGLWEKISSPGS
uniprot
proteins
ec_number
3.5.1.121
uniprot
proteins
function
FUNCTION: N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn. {ECO:0000269|PubMed:21375249}.
uniprot
proteins
mass_dalton
34677
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="P->G: 3-fold reduction in catalytic activity."; /evidence="ECO:0000269|PubMed:21375249"; MUTAGEN 75; /note="C->A,S,T: Abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:21375249
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21375249
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q28955}.
uniprot
proteins