SUMO2
entrez
6613
canonical
uniprot
P61956
canonical
ensembl
ENSG00000188612
resolver
ensp
ENSP00000400886
resolver
ensp
ENSP00000405965
resolver
genesymbol
SUMO2
resolver
genesymbol_syn
SMT3B
resolver
genesymbol_syn
SMT3H2
resolver
hgnc
HGNC:11125
resolver
uniprot
B2R4I2
resolver
uniprot
P55855
resolver
uniprot
Q32Q42
resolver
uniprot
Q6IPZ6
resolver
uniprot
Q96HK1
resolver
uniprot_entry
SUMO2_HUMAN
resolver
uniprot_sec
B2R4I2
resolver
uniprot_sec
P55855
resolver
uniprot_sec
Q32Q42
resolver
uniprot_sec
Q6IPZ6
resolver
uniprot_sec
Q96HK1
resolver
amino_acid_sequence
MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY
uniprot
proteins
function
FUNCTION: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26524494, ECO:0000269|PubMed:9556629}.
uniprot
proteins
mass_dalton
10871
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="K->R: Abolishes the formation of poly(SUMO) chains."; /evidence="ECO:0000269|PubMed:11451954"; MUTAGEN 33; /note="K->E: Significantly impairs sumoylation of MTA1."; /evidence="ECO:0000269|PubMed:21965678"; MUTAGEN 35; /note="K->E: Significantly impairs sumoylation of MTA1."; /evidence="ECO:0000269|PubMed:21965678"; MUTAGEN 42; /note="K->E: Significantly impairs sumoylation of MTA1."; /evidence="ECO:0000269|PubMed:21965678
uniprot
proteins
post_translational_modification
PTM: Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4. {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:23560854}.; PTM: Cleavage of precursor form by SENP1 or SENP2 is necessary for function. {ECO:0000269|PubMed:15487983}.; PTM: Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer. {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:23560854}.
uniprot
proteins
protein_family
SUMO subfamily
uniprot
proteins
protein_family
Ubiquitin family
uniprot
proteins
pubmed
10692421
uniprot
proteins
pubmed
11451954
uniprot
proteins
pubmed
12383504
uniprot
proteins
pubmed
12924945
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15296745
uniprot
proteins
pubmed
15479240
uniprot
proteins
pubmed
15487983
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16567619
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16626738
uniprot
proteins
pubmed
18408734
uniprot
proteins
pubmed
18538659
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20388717
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21965678
uniprot
proteins
pubmed
22398289
uniprot
proteins
pubmed
22406621
uniprot
proteins
pubmed
23086935
uniprot
proteins
pubmed
23560854
uniprot
proteins
pubmed
24105744
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
26524494
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
30914427
uniprot
proteins
pubmed
36369429
uniprot
proteins
pubmed
8630065
uniprot
proteins
pubmed
9119407
uniprot
proteins
pubmed
9556629
uniprot
proteins
sequence_length
95
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body.
uniprot
proteins