Mapk6
entrez
50772
canonical
uniprot
Q61532
canonical
ensembl
ENSMUSG00000042688
resolver
ensp
ENSMUSP00000040315
resolver
ensp
ENSMUSP00000129024
resolver
enst
ENSMUST00000049355
resolver
enst
ENSMUST00000168937
resolver
genesymbol
Mapk6
resolver
genesymbol_syn
Erk3
resolver
genesymbol_syn
Prkm4
resolver
genesymbol_syn
Prkm6
resolver
uniprot
Q497T9
resolver
uniprot
Q6YKB0
resolver
uniprot
Q7TT30
resolver
uniprot
Q80XH5
resolver
uniprot
Q922U4
resolver
uniprot
Q9JLU6
resolver
uniprot_entry
MK06_MOUSE
resolver
uniprot_sec
Q497T9
resolver
uniprot_sec
Q6YKB0
resolver
uniprot_sec
Q7TT30
resolver
uniprot_sec
Q80XH5
resolver
uniprot_sec
Q922U4
resolver
uniprot_sec
Q9JLU6
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation at Ser-189.
uniprot
proteins
amino_acid_sequence
MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILDSIPVVHEEDRQELLSVIPVYIRNDMTEPHRPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPTDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPIHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTSYSAEPCWQYPDHHENKYCDLECSHTCNYKTRSSPYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKRGKSKCERNGLVKAQIALEEASQQLAERERGQGFDFDSFIAGTIQLSAQHQSADVVDKLNDLNSSVSQLELKSLISKSVSREKQEKGRANLAQLGALYQSSWDSQFVSGGEECFLISQFCCEVRKDEHAEKENTYTSYLDKFFSRKEDSEMLETEPVEEGKRGERGREAGLLSGGGEFLLSKQLESIGTPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHKTYSSILKHLN
uniprot
proteins
ec_number
2.7.11.24
uniprot
proteins
function
FUNCTION: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle. {ECO:0000269|PubMed:15538386, ECO:0000269|PubMed:15577943}.
uniprot
proteins
mass_dalton
82199
uniprot
proteins
mutagenesis
MUTAGEN 171; /note="D->A: Kinase defective mutant, abolishes activity."; /evidence="ECO:0000269|PubMed:15577943"; MUTAGEN 189; /note="S->A: Unable to activate MAPKAPK5 promote MAPKAPK5 localization to the cytoplasm."; /evidence="ECO:0000269|PubMed:15577943, ECO:0000269|PubMed:18720373"; MUTAGEN 189; /note="S->E: Mimicks phosphorylation state and induces constitutive protein kinase activity."; /evidence="ECO:0000269|PubMed:15577943, ECO:0000269|PubMed:18720373"; MUTAGEN 334; /note="I->K: Abolishes binding to MAPKAPK5."; /evidence="ECO:0000269|PubMed:19473979
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. {ECO:0000269|PubMed:18720373}.; PTM: Ubiquitination at Met-1 leads to degradation by the proteasome pathway. {ECO:0000250}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MAP kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10657254
uniprot
proteins
pubmed
12504858
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15538386
uniprot
proteins
pubmed
15577943
uniprot
proteins
pubmed
16973613
uniprot
proteins
pubmed
18720373
uniprot
proteins
pubmed
19473979
uniprot
proteins
pubmed
8444355
uniprot
proteins
sequence_length
720
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5.
uniprot
proteins