Tbx2
entrez
21385
canonical
uniprot
Q60707
canonical
ensembl
ENSMUSG00000000093
resolver
ensp
ENSMUSP00000000095
resolver
enst
ENSMUST00000000095
resolver
genesymbol
Tbx2
resolver
uniprot
Q3UET7
resolver
uniprot
Q5SSP7
resolver
uniprot_entry
Q3UET7_MOUSE
resolver
uniprot_entry
TBX2_MOUSE
resolver
uniprot_sec
Q5SSP7
resolver
amino_acid_sequence
MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPPGALGKPLPDPGLAGAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPTLRLYEEHCKPERDGAESDASSCDPPPAREPPPSPSAAPSPLRLHRARAEEKPGAADSDPEPERTGEERSAAPLGRSPSRDASPARLTEPERSRERRSPERCSKEPTEGGGDGPFSLRSLEKERPEARRKDEGRKDVGEGKEPSLAPLVVQTDSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFAMGPGAFSAMGMGHLLASVAGGSGSSGGAGPGTAAGLDAGGLGPAASAASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSLSRSPFLGSARPRLRFSPYQIPVTIPPSTSLLTTGLAAEGSKGGNSREPSPLPELALRKVGGPSRGALSPSGSAKEAASELQSIQRLVSGLESQRALSPGRESPK
uniprot
proteins
function
FUNCTION: Transcription factor which acts as a transcriptional repressor (PubMed:11867218, PubMed:12023302, PubMed:18025091, PubMed:22186728). May also function as a transcriptional activator (PubMed:11867218, PubMed:22186728, PubMed:26486273). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12023302, PubMed:26971330, PubMed:27720610, PubMed:33731112, PubMed:9710594). Required for cardiac atrioventricular canal formation (PubMed:15459098). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (PubMed:12023302). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (PubMed:22186728). Plays a role in limb pattern formation (PubMed:15459098). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (PubMed:16222716, PubMed:27720610). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (PubMed:27720610). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (PubMed:33795231). Acts as a negative regulator of PML function in cellular senescence (By similarity). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (PubMed:18025091, PubMed:33731112). Negatively modulates expression of CDKN2A/p19ARF and CDH1/E-cadherin (By similarity). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (By similarity). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (PubMed:26486273). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (PubMed:26971330, PubMed:9710594). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q13207, ECO:0000269|PubMed:11867218, ECO:0000269|PubMed:12023302, ECO:0000269|PubMed:15459098, ECO:0000269|PubMed:16222716, ECO:0000269|PubMed:18025091, ECO:0000269|PubMed:22186728, ECO:0000269|PubMed:26486273, ECO:0000269|PubMed:26971330, ECO:0000269|PubMed:27720610, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:30599067, ECO:0000269|PubMed:33731112, ECO:0000269|PubMed:33795231, ECO:0000269|PubMed:9710594}.
uniprot
proteins
mass_dalton
75081
uniprot
proteins
mutagenesis
MUTAGEN 132..133; /note="RR->EE: Attenuated repression of Adam10 transcription."; /evidence="ECO:0000269|PubMed:30599067"; MUTAGEN 336; /note="S->A: Abolishes phosphorylation."; /evidence="ECO:0000269|PubMed:18025091"; MUTAGEN 623; /note="S->A: Abolishes phosphorylation."; /evidence="ECO:0000269|PubMed:18025091"; MUTAGEN 675; /note="S->A: Abolishes phosphorylation."; /evidence="ECO:0000269|PubMed:18025091
uniprot
proteins
post_translational_modification
PTM: Phosphorylated (PubMed:18025091). May be phosphorylated by p38 MAPK in response to UV irradiation stress (PubMed:18025091). {ECO:0000269|PubMed:18025091}.
uniprot
proteins
pubmed
10770922
uniprot
proteins
pubmed
11867218
uniprot
proteins
pubmed
12023302
uniprot
proteins
pubmed
15459098
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16222716
uniprot
proteins
pubmed
18025091
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22186728
uniprot
proteins
pubmed
26486273
uniprot
proteins
pubmed
26971330
uniprot
proteins
pubmed
27720610
uniprot
proteins
pubmed
28910203
uniprot
proteins
pubmed
30599067
uniprot
proteins
pubmed
33731112
uniprot
proteins
pubmed
33795231
uniprot
proteins
pubmed
7920656
uniprot
proteins
pubmed
8853987
uniprot
proteins
pubmed
9710594
uniprot
proteins
sequence_length
711
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26486273, ECO:0000269|PubMed:33731112}.
uniprot
proteins