TNFAIP8
entrez
25816
canonical
uniprot
O95379
canonical
ensembl
ENSG00000145779
resolver
ensp
ENSP00000274456
resolver
ensp
ENSP00000421848
resolver
ensp
ENSP00000422245
resolver
ensp
ENSP00000427424
resolver
genesymbol
TNFAIP8
resolver
hgnc
HGNC:17260
resolver
uniprot
B3KMH1
resolver
uniprot
B3KMI2
resolver
uniprot
B3KUI2
resolver
uniprot
B7Z713
resolver
uniprot
Q9P1Q1
resolver
uniprot
Q9UER5
resolver
uniprot
Q9UP47
resolver
uniprot_entry
B3KUI2_HUMAN
resolver
uniprot_entry
TFIP8_HUMAN
resolver
uniprot_sec
B3KMH1
resolver
uniprot_sec
B3KMI2
resolver
uniprot_sec
B7Z713
resolver
uniprot_sec
Q9P1Q1
resolver
uniprot_sec
Q9UER5
resolver
uniprot_sec
Q9UP47
resolver
amino_acid_sequence
MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVDYTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKPHLQKLCDGINKMLDEENI
uniprot
proteins
function
FUNCTION: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. {ECO:0000269|PubMed:10644768, ECO:0000269|PubMed:11346652, ECO:0000269|PubMed:14724590}.
uniprot
proteins
mass_dalton
23003
uniprot
proteins
protein_family
TNFAIP8 family
uniprot
proteins
pubmed
10233894
uniprot
proteins
pubmed
10644768
uniprot
proteins
pubmed
11346652
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14724590
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14724590}.
uniprot
proteins