PPP4R1
entrez
9989
canonical
uniprot
Q8TF05
canonical
ensembl
ENSG00000154845
resolver
ensp
ENSP00000383401
resolver
ensp
ENSP00000383402
resolver
ensp
ENSP00000556351
resolver
ensp
ENSP00000594215
resolver
ensp
ENSP00000661297
resolver
genesymbol
PPP4R1
resolver
genesymbol_syn
MEG1
resolver
genesymbol_syn
PP4R1
resolver
hgnc
HGNC:9320
resolver
uniprot
Q99774
resolver
uniprot
Q9UNQ7
resolver
uniprot_entry
PP4R1_HUMAN
resolver
uniprot_sec
Q99774
resolver
uniprot_sec
Q9UNQ7
resolver
amino_acid_sequence
MADLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASSTY
uniprot
proteins
function
FUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhibition of TNF-induced NF-kappa-B activation by regulating the dephosphorylation of TRAF2. {ECO:0000269|PubMed:15805470}.; FUNCTION: (Microbial infection) Participates in merkel polyomavirus-mediated inhibition of NF-kappa-B by bridging viral small tumor antigen with NEMO. {ECO:0000269|PubMed:28445980}.
uniprot
proteins
mass_dalton
107004
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF(FBXO42) complex; leading to proteasomal degradation. {ECO:0000269|PubMed:41484364}.
uniprot
proteins
pubmed
10026142
uniprot
proteins
pubmed
11729228
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15805470
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
18614045
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25134449
uniprot
proteins
pubmed
28445980
uniprot
proteins
pubmed
41484364
uniprot
proteins
pubmed
9110174
uniprot
proteins
sequence_length
950
uniprot
proteins