Nme5
entrez
75533
canonical
uniprot
Q99MH5
canonical
ensembl
ENSMUSG00000035984
resolver
ensp
ENSMUSP00000078269
resolver
genesymbol
Nme5
resolver
genesymbol_syn
Rsph23
resolver
uniprot
Q3V2L8
resolver
uniprot
Q810R1
resolver
uniprot_entry
NDK5_MOUSE
resolver
uniprot_entry
Q3V2L8_MOUSE
resolver
uniprot_sec
Q810R1
resolver
amino_acid_sequence
MEVSMPLPQIYVEKTLALIKPDVVDKEEEIQDIILGSGFTIIQRRKLHLSPEHCSNFYVEQYGKMFFPNLTAYMSSGPLVAMILARHKAISYWKELMGPSNSLVAKETHPDSLRAIYGTDELRNALHGSNDFAASEREIRFMFPAVIIEPIPIGQAAKDYINLYVAPTLLQGLTELCKEKPPDPYLWLADWLMKNNPNKPKLCHFPVTEEP
uniprot
proteins
ec_number
3.1.11.-
uniprot
proteins
function
FUNCTION: Functions as part of axonemal radial spoke complexes, which play an important part in the motility of sperm and cilia (PubMed:36417862). In vitro, does not display nucleoside diphosphate kinase (NDPK) activity. Exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing (By similarity). Confers protection from cell death mediated by BAX and alters the cellular levels of several antioxidant enzymes, including GPX5 (PubMed:12788088). Might be involved in spermiogenesis by enhancing the ability of late-stage spermatids to eliminate reactive oxygen species (PubMed:12788088). {ECO:0000250|UniProtKB:P56597, ECO:0000269|PubMed:12788088, ECO:0000269|PubMed:36417862}.
uniprot
proteins
mass_dalton
24002
uniprot
proteins
protein_family
NDK family
uniprot
proteins
pubmed
12788088
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32203505
uniprot
proteins
pubmed
36417862
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:32203505}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000305|PubMed:36417862}.
uniprot
proteins