Slc27a2
entrez
26458
canonical
uniprot
O35488
canonical
ensembl
ENSMUSG00000027359
resolver
ensp
ENSMUSP00000057595
resolver
enst
ENSMUST00000061491
resolver
genesymbol
Slc27a2
resolver
genesymbol_syn
Acsvl1
resolver
genesymbol_syn
Facvl1
resolver
genesymbol_syn
Fatp2
resolver
genesymbol_syn
Vlacs
resolver
genesymbol_syn
Vlcs
resolver
uniprot
O70550
resolver
uniprot
O88560
resolver
uniprot
Q3TN99
resolver
uniprot
Q91WV6
resolver
uniprot_entry
Q3TN99_MOUSE
resolver
uniprot_entry
S27A2_MOUSE
resolver
uniprot_sec
O70550
resolver
uniprot_sec
O88560
resolver
uniprot_sec
Q91WV6
resolver
amino_acid_sequence
MLPVLYTGLAGLLLLPLLLTCCCPYLLQDVRYFLRLANMARRVRSYRQRRPVRTILRAFLEQARKTPHKPFLLFRDETLTYAQVDRRSNQVARALHDQLGLRQGDCVALFMGNEPAYVWIWLGLLKLGCPMACLNYNIRAKSLLHCFQCCGAKVLLASPDLQEAVEEVLPTLKKDAVSVFYVSRTSNTNGVDTILDKVDGVSAEPTPESWRSEVTFTTPAVYIYTSGTTGLPKAATINHHRLWYGTGLAMSSGITAQDVIYTTMPLYHSAALMIGLHGCIVVGATLALRSKFSASQFWDDCRKYNVTVIQYIGELLRYLCNTPQKPNDRDHKVKKALGNGLRGDVWREFIKRFGDIHVYEFYASTEGNIGFVNYPRKIGAVGRANYLQRKVARYELIKYDVEKDEPVRDANGYCIKVPKGEVGLLVCKITQLTPFIGYAGGKTQTEKKKLRDVFKKGDIYFNSGDLLMIDRENFVYFHDRVGDTFRWKGENVATTEVADIVGLVDFVEEVNVYGVPVPGHEGRIGMASLKIKENYEFNGKKLFQHIAEYLPSYARPRFLRIQDTIEITGTFKHRKVTLMEEGFNPTVIKDTLYFMDDAEKTFVPMTENIYNAIIDKTLKL
uniprot
proteins
ec_number
6.2.1.-
uniprot
proteins
ec_number
6.2.1.15
uniprot
proteins
ec_number
6.2.1.24
uniprot
proteins
ec_number
6.2.1.3
uniprot
proteins
ec_number
6.2.1.7
uniprot
proteins
function
FUNCTION: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (PubMed:15699031, PubMed:20530735, PubMed:9671728). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:15699031, PubMed:20530735). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:15699031, PubMed:20530735). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (By similarity). May contribute to the synthesis of sphingosine-1-phosphate (By similarity). Does not activate C24 bile acids, cholate and chenodeoxycholate (By similarity). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. However, it is not critical for THCA activation and bile synthesis in vivo (By similarity). {ECO:0000250|UniProtKB:O14975, ECO:0000269|PubMed:15699031, ECO:0000269|PubMed:20530735, ECO:0000269|PubMed:9671728}.
uniprot
proteins
mass_dalton
70423
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
11980911
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15699031
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20530735
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
9559670
uniprot
proteins
pubmed
9671728
uniprot
proteins
sequence_length
620
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O14975}; Multi-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000269|PubMed:20530735}; Peripheral membrane protein {ECO:0000250|UniProtKB:P97524}. Cell membrane {ECO:0000269|PubMed:20530735}; Multi-pass membrane protein {ECO:0000255}. Microsome {ECO:0000250|UniProtKB:P97524}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..27; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 107..127; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 268..288; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins