Sh3glb1
entrez
292156
canonical
uniprot
Q6AYE2
canonical
ensembl
ENSRNOG00000012957
resolver
ensp
ENSRNOP00000078654
resolver
ensp
ENSRNOP00000092051
resolver
ensp
ENSRNOP00000093719
resolver
enst
ENSRNOT00000104475
resolver
enst
ENSRNOT00000109147
resolver
genesymbol
Sh3glb1
resolver
uniprot
A0A8I5ZL78
resolver
uniprot
A0A8I6AKY2
resolver
uniprot_entry
A0A8I5ZL78_RAT
resolver
uniprot_entry
A0A8I6AKY2_RAT
resolver
uniprot_entry
SHLB1_RAT
resolver
amino_acid_sequence
MNIMDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLENLLSKAECTKVWTEKIMKQTEVLLQPNPNARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETKSSSEQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYVSNNNQTSGTPVPYTLSNTIGPSAVASTGSLVITCPPNLSDLKDSSSTRKARVLYDYDAANSTELSLLADEVITVFSVVGMDSDWLMGERGNQKGKVPITYLELLN
uniprot
proteins
function
FUNCTION: May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). {ECO:0000250|UniProtKB:Q9JK48, ECO:0000250|UniProtKB:Q9Y371}.
uniprot
proteins
mass_dalton
40787
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization. {ECO:0000250}.
uniprot
proteins
protein_family
Endophilin family
uniprot
proteins
pubmed
11604418
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11604418}. Golgi apparatus membrane {ECO:0000269|PubMed:11604418}; Peripheral membrane protein {ECO:0000269|PubMed:11604418}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9JK48, ECO:0000250|UniProtKB:Q9Y371}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JK48, ECO:0000250|UniProtKB:Q9Y371}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q9Y371}. Midbody {ECO:0000250|UniProtKB:Q9Y371}. Note=Association with the Golgi apparatus depends on the cell type. Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes. {ECO:0000250|UniProtKB:Q9JK48, ECO:0000250|UniProtKB:Q9Y371, ECO:0000269|PubMed:11604418}.
uniprot
proteins