Kank2
entrez
100361376
canonical
uniprot
D3ZD05
canonical
ensembl
ENSRNOG00000010643
resolver
ensembl
ENSRNOG00055013087
resolver
ensembl
ENSRNOG00060025933
resolver
ensembl
ENSRNOG00065015631
resolver
ensp
ENSRNOP00000014135
resolver
ensp
ENSRNOP00055018167
resolver
ensp
ENSRNOP00060037266
resolver
ensp
ENSRNOP00065020454
resolver
enst
ENSRNOT00000014135
resolver
enst
ENSRNOT00055022398
resolver
enst
ENSRNOT00060044926
resolver
enst
ENSRNOT00065025982
resolver
genesymbol
Kank2
resolver
uniprot
D4ACC2
resolver
uniprot_entry
D4ACC2_RAT
resolver
uniprot_entry
KANK2_RAT
resolver
amino_acid_sequence
MAQVLHVPAPFPGTPGQASSAAFPNKEPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVPVQRRPRLGSLPRGPGSWWTSTESLCSDASGDSRHSAYSYCGRGFYPQYGALETRSGTNPRVERTLLDARRRLEDQAAAPSSGGLGSLTPSAAGSTSSLAGVGLLPPTPRSSGLSTPVAPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPSGTRSRSELCLDLPEAPDDPAVLETRSVGTWVRERDLGIPDGEAALVAKVAVLETQLKKALQELRAAQTQQVDLQPQAWPPPDTQVRVDTVRVVEGPREVEVAASTAAGAPAQRAQSLEPYGAGLKALATSAENTLVFRSHEVVETMCPLPTASTSNMHTAKKISITERNCTGAARMADPPPSPAEPSPSSPYPAAEPENPAPAAQDTTDRELTRPVASQDSQAAEGAGGASLGVQSALKRKEVPADPDVHQRNLQFVGINGGYESSSEDSSTAENSEHESTENEAPEPPVRVLSTAEGPQLRPLGPAVGKTSQDERQLSQESQRVPEAKVAPGPDPEEEIRMDLSPDLISACLALEKYLENPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVCQVDKLNRAGYSPIMLTALATLKTQDDIDTILQLFRLGNVNAKASQAGQTALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSDYESPASSSAEE
uniprot
proteins
function
FUNCTION: Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (By similarity). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q63ZY3, ECO:0000250|UniProtKB:Q8BX02}.
uniprot
proteins
mass_dalton
90884
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by casein kinase II upon estrogen stimulation (By similarity). Phosphorylation induces the release by KANK2 of NCOA1 and its translocation to the nucleus where NCOA1 can activate gene transcription (By similarity). {ECO:0000250|UniProtKB:Q63ZY3}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
25961457
uniprot
proteins
sequence_length
847
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q63ZY3}. Mitochondrion {ECO:0000250|UniProtKB:Q63ZY3}.
uniprot
proteins