Sec61g
entrez
20335
canonical
uniprot
P60060
canonical
ensembl
ENSMUSG00000078974
resolver
ensp
ENSMUSP00000105269
resolver
ensp
ENSMUSP00000105270
resolver
ensp
ENSMUSP00000105271
resolver
ensp
ENSMUSP00000132348
resolver
ensp
ENSMUSP00000137362
resolver
enst
ENSMUST00000109641
resolver
enst
ENSMUST00000109642
resolver
enst
ENSMUST00000109643
resolver
enst
ENSMUST00000166950
resolver
enst
ENSMUST00000178855
resolver
genesymbol
Sec61g
resolver
uniprot
G3UWH0
resolver
uniprot
P38384
resolver
uniprot
Q5SWJ8
resolver
uniprot_entry
G3UWH0_MOUSE
resolver
uniprot_entry
Q5SWJ8_MOUSE
resolver
uniprot_entry
SC61G_MOUSE
resolver
uniprot_sec
P38384
resolver
amino_acid_sequence
MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG
uniprot
proteins
function
FUNCTION: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (By similarity). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity). {ECO:0000250|UniProtKB:P60058, ECO:0000250|UniProtKB:P60059, ECO:0000250|UniProtKB:P61619}.
uniprot
proteins
mass_dalton
7741
uniprot
proteins
protein_family
SecE/SEC61-gamma family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
68
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P60059}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..61; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins