Lepr
entrez
24536
canonical
uniprot
Q62959
canonical
ensembl
ENSRNOG00000023664
resolver
ensp
ENSRNOP00000045398
resolver
ensp
ENSRNOP00000080721
resolver
ensp
ENSRNOP00000093122
resolver
enst
ENSRNOT00000044131
resolver
enst
ENSRNOT00000050597
resolver
enst
ENSRNOT00000093574
resolver
genesymbol
Lepr
resolver
genesymbol_syn
Fa
resolver
genesymbol_syn
Obr
resolver
uniprot
A0A8I5ZQD9
resolver
uniprot
A0A8I6AJP1
resolver
uniprot
F1M9F2
resolver
uniprot
O35772
resolver
uniprot
O35773
resolver
uniprot
O54805
resolver
uniprot
P70493
resolver
uniprot
P70494
resolver
uniprot
P70495
resolver
uniprot
P97589
resolver
uniprot
Q62960
resolver
uniprot
Q63007
resolver
uniprot
Q63385
resolver
uniprot
Q63386
resolver
uniprot
Q9ERI4
resolver
uniprot_entry
A0A8I5ZQD9_RAT
resolver
uniprot_entry
A0A8I6AJP1_RAT
resolver
uniprot_entry
F1M9F2_RAT
resolver
uniprot_entry
LEPR_RAT
resolver
uniprot_sec
O35772
resolver
uniprot_sec
O35773
resolver
uniprot_sec
O54805
resolver
uniprot_sec
P70493
resolver
uniprot_sec
P70494
resolver
uniprot_sec
P70495
resolver
uniprot_sec
P97589
resolver
uniprot_sec
Q62960
resolver
uniprot_sec
Q63007
resolver
uniprot_sec
Q63385
resolver
uniprot_sec
Q63386
resolver
uniprot_sec
Q9ERI4
resolver
amino_acid_sequence
MTCQKFYVVLLHWEFLYVITALNLAYPTSPWRFKLFCAPPSTTDDSFLSPAGVPNNTSSLKGASEALVEAKFNSTGIYVSELSKTIFHCCFGNEQGQNCSALTGNTEGKTLASVVKPLVFRQLGVNWDIECWMKGDLTLFICHMEPLLKNPFKNYDSKVHLLYDLPEVIDDLPLPPLKDSFQTVQCNCSVRECECHVPVPRAKVNYALLMYLEITSAGVSFQSPLMSLQPMLVVKPDPPLGLRMEVTDDGNLKISWDSQTKAPFPLQYQVKYLENSTIVREAAEIVSDTSLLVDSVLPGSSYEVQVRSKRLDGSGVWSDWSLPQLFTTQDVMYFPPKILTSVGSNASFCCIYKNENQTISSKQIVWWMNLAEKIPETQYNTVSDHISKVTFSNLKATRPRGKFTYDAVYCCNEQACHHRYAELYVIDVNINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDNPSIRPTSELKNCVLQTDGFYECVFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSNVKAEITINTGLLKVSWEKPVFPENNLQFQIRYGLNGKEIQWKTHEVFDAKSKSASLPVSDLCAVYVVQVRCRRLDGLGYWSNWSSPAYTLVMDVKVPMRGPEFWRIMDGDITKKERNVTLLWKPLMKNDSLCSVRRYVVKHRTAHNGTWSQDVGNQTNLTFLWAESAHTVTVLAINSIGASLVNFNLTFSWPMSKVNAVQSLSAYPLSSSCVILSWTLSPNDYSLLYLVIEWKNLNDDDGMKWLRIPSNVNKYYIHDNFIPIEKYQFSLYPVFMEGVGKPKIINGFTKDDIAKQQNDAGLYVIVPIIISSCVLLLGTLLISHQRMKKLFWDDVPNPKNCSWAQGLNFQKPETFEHLFTKHAESVIFGPLLLEPEPVSEEISVDTAWKNKDEMVPAAMVSLLLTTPDSTRGSICISDQCNSANFSGAQSTQGTCEDECQSQPSVKYATLVSNVKTVETDEEQGAIHSSVSQCIARKHSPLRQSFSSNSWEIEAQAFFLLSDHPPNVISPQLSFSGLDELLELEGNFPEENHGEKSVYYLGVSSGNKRENDMLLTDEAGVLCPFPAHCLFSDIRILQESCSHFVENNLNLGTSGKNFVPYMPQFQSCSTHSHKIIENKMCDLTV
uniprot
proteins
disease_involvement
DISEASE: Note=The fatty (Fa) mutation produces profound obesity of early onset caused by hyperphagia, defective non-shivering thermogenesis, and preferential deposition of energy into adipose tissue.
uniprot
proteins
function
FUNCTION: Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:8690163). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (By similarity). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity). {ECO:0000250|UniProtKB:P48356, ECO:0000250|UniProtKB:P48357, ECO:0000269|PubMed:8690163, ECO:0000305|PubMed:25232147}.; FUNCTION: [Isoform A]: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis (PubMed:10698121). Does not induce phosphorylation of and activate STAT3 (By similarity). {ECO:0000250|UniProtKB:P48356, ECO:0000269|PubMed:10698121}.; FUNCTION: [Isoform E]: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis. {ECO:0000250|UniProtKB:P48356}.
uniprot
proteins
mass_dalton
130833
uniprot
proteins
post_translational_modification
PTM: On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-985 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1138 is required for STAT3 binding/activation. Phosphorylation of Tyr-1077 has a more accessory role. {ECO:0000250|UniProtKB:P48356}.
uniprot
proteins
protein_family
Type 2 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
10698121
uniprot
proteins
pubmed
11861497
uniprot
proteins
pubmed
25232147
uniprot
proteins
pubmed
8630068
uniprot
proteins
pubmed
8673096
uniprot
proteins
pubmed
8690163
uniprot
proteins
pubmed
8702432
uniprot
proteins
pubmed
8769097
uniprot
proteins
pubmed
8772180
uniprot
proteins
pubmed
9268737
uniprot
proteins
sequence_length
1162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P48357}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P48357}. Basolateral cell membrane {ECO:0000250|UniProtKB:P48357}.; SUBCELLULAR LOCATION: [Isoform E]: Secreted {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 840..860; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins