Retreg1
entrez
619558
canonical
uniprot
Q5FVM3
canonical
ensembl
ENSRNOG00000010589
resolver
ensembl
ENSRNOG00055000229
resolver
ensembl
ENSRNOG00060021044
resolver
ensembl
ENSRNOG00065015146
resolver
ensp
ENSRNOP00000098260
resolver
ensp
ENSRNOP00000100789
resolver
ensp
ENSRNOP00055000287
resolver
ensp
ENSRNOP00060030400
resolver
ensp
ENSRNOP00065019712
resolver
enst
ENSRNOT00000120625
resolver
enst
ENSRNOT00055000403
resolver
enst
ENSRNOT00060036890
resolver
enst
ENSRNOT00065025172
resolver
genesymbol
Retreg1
resolver
genesymbol_syn
Fam134b
resolver
uniprot_entry
RETR1_RAT
resolver
amino_acid_sequence
MASPAPEEHATQGCPATEEQEPRPGVPGEEAGPEGAGPQVEEAAGRVAAALTWLLGEPVLWLGWRADELLSWKRPLRSLLAFLGANLLFWFLALTPWRVYHLISVMILGRVIMQIIKDMVLSRARGAQLWRSLSESWEVINSKPDERPRLSHCIAESWMNFSIFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYLLLLFAFLCPLFKCNDIGQKIYSKVKSILLKLDFGIGEYINQKKRERSEADKEKSHKDDSEIDFSALCPKISLTVAAKELSVSDTDVSEVSWTDNGTFNLSEGYTPQTDTSDDLDRPSEEVFSRDLSDFPSLENGAGTNDEDELSLGLPTELKTKKQQLNSAHRPSKDRQSAAGLSLPLKSDQALHLMSNLAGDVITAAMTAAIKDQLEGARQALAQAAPTPGDDTDTEEGDDFELLDQAELDQIESELGLTQDQGAEAQQSKKSSGFLSNLLGGH
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Active under basal conditions. Required for collagen quality control in a LIR motif-dependent manner. Required for long-term survival of nociceptive and autonomic ganglion neurons. {ECO:0000250|UniProtKB:Q8VE91, ECO:0000250|UniProtKB:Q9H6L5}.
uniprot
proteins
mass_dalton
52782
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-134 by CAMK2B enhances oligomerization and membrane scission and reticulophagy activity. {ECO:0000250|UniProtKB:Q9H6L5}.
uniprot
proteins
protein_family
RETREG family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q8VE91}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9H6L5}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..64; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins