Igf1
entrez
24482
canonical
uniprot
P08025
canonical
ensembl
ENSRNOG00000004517
resolver
ensp
ENSRNOP00000005995
resolver
ensp
ENSRNOP00000035899
resolver
ensp
ENSRNOP00000097781
resolver
ensp
ENSRNOP00000100217
resolver
ensp
ENSRNOP00000110287
resolver
enst
ENSRNOT00000005995
resolver
enst
ENSRNOT00000139084
resolver
genesymbol
Igf1
resolver
genesymbol_syn
Igf-1
resolver
uniprot
A0ABK0KYM9
resolver
uniprot
F8WFZ5
resolver
uniprot
P08024
resolver
uniprot
Q5RK13
resolver
uniprot
Q63261
resolver
uniprot_entry
A0ABK0KYM9_RAT
resolver
uniprot_entry
F8WFZ5_RAT
resolver
uniprot_entry
IGF1_RAT
resolver
uniprot_entry
Q5RK13_RAT
resolver
uniprot_entry
Q63261_RAT
resolver
uniprot_sec
P08024
resolver
amino_acid_sequence
MGKISSLPTQLFKICLCDFLKIKIHIMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGPRGFYFNKPTGYGSSIRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPTKSARSIRAQRHTDMPKTQKEVHLKNTSRGSAGNKTYRM
uniprot
proteins
function
FUNCTION: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity). As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (PubMed:20724525). {ECO:0000250|UniProtKB:P05017, ECO:0000250|UniProtKB:P05019, ECO:0000269|PubMed:20724525}.
uniprot
proteins
mass_dalton
17079
uniprot
proteins
protein_family
Insulin family
uniprot
proteins
pubmed
1368571
uniprot
proteins
pubmed
20724525
uniprot
proteins
pubmed
2538424
uniprot
proteins
pubmed
3034909
uniprot
proteins
pubmed
3453891
uniprot
proteins
pubmed
3595538
uniprot
proteins
pubmed
3652906
uniprot
proteins
pubmed
3658684
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P05017}.
uniprot
proteins