Pqbp1
entrez
302557
canonical
uniprot
Q6PCT5
canonical
ensembl
ENSRNOG00000007766
resolver
ensembl
ENSRNOG00055027058
resolver
ensembl
ENSRNOG00060021122
resolver
ensembl
ENSRNOG00065011256
resolver
ensp
ENSRNOP00000010536
resolver
ensp
ENSRNOP00055038413
resolver
ensp
ENSRNOP00060030206
resolver
ensp
ENSRNOP00065013931
resolver
enst
ENSRNOT00000010536
resolver
enst
ENSRNOT00055046778
resolver
enst
ENSRNOT00060036695
resolver
enst
ENSRNOT00065018252
resolver
genesymbol
Pqbp1
resolver
uniprot
G3V705
resolver
uniprot_entry
G3V705_RAT
resolver
uniprot_entry
PQBP1_RAT
resolver
amino_acid_sequence
MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRIEGLPPSWYKVFDPSCGLPYYWNVETDLVSWLSPHDPNFVVSKSAKKLRNSNADAEDKSERNLEKVDRNHEKSDRSHEKPDRSHEKADRNHEKSDRERERNYDKVDRERDRDRERERAFDKADREDGKDRRHHRREELAPYPKNKKATSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRSKQQD
uniprot
proteins
function
FUNCTION: Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules. Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production. {ECO:0000250|UniProtKB:O60828}.
uniprot
proteins
mass_dalton
30529
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
263
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O60828}. Nucleus speckle {ECO:0000250|UniProtKB:Q91VJ5}. Cytoplasmic granule {ECO:0000250|UniProtKB:O60828}. Note=Colocalizes with SRSF2 in nuclear speckles (By similarity). Colocalized with POU3F2. Colocalized with ATXN1 in nuclear inclusion bodies. Localizes to cytoplasmic stress granules (By similarity). {ECO:0000250|UniProtKB:O60828, ECO:0000250|UniProtKB:Q91VJ5}.
uniprot
proteins