Scn3b
entrez
235281
canonical
uniprot
Q8BHK2
canonical
ensembl
ENSMUSG00000049281
resolver
ensp
ENSMUSP00000051627
resolver
ensp
ENSMUSP00000110606
resolver
ensp
ENSMUSP00000132933
resolver
ensp
ENSMUSP00000135096
resolver
ensp
ENSMUSP00000170417
resolver
enst
ENSMUST00000049941
resolver
enst
ENSMUST00000114956
resolver
enst
ENSMUST00000171835
resolver
enst
ENSMUST00000176185
resolver
genesymbol
Scn3b
resolver
uniprot
H3BJR6
resolver
uniprot
Q0P666
resolver
uniprot
Q91Z99
resolver
uniprot_entry
H3BJR6_MOUSE
resolver
uniprot_entry
Q0P666_MOUSE
resolver
uniprot_entry
SCN3B_MOUSE
resolver
uniprot_sec
Q91Z99
resolver
amino_acid_sequence
MPAFNRLLPLASLVLIYWVRVCFPVCVEVPSETEAVQGNSMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLFIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSVVPVEE
uniprot
proteins
function
FUNCTION: Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels (By similarity). Modulates the activity of SCN2A/Nav1.2, causing a hyperpolarizing shift in the voltage-dependence of inactivation of the channel and increasing the fraction of channels operating in the fast gating mode (By similarity). Modulates the activity of SCN5A/Nav1.5. Could also regulate the atypical sodium channel SCN7A/Nav2.1. Modulates the activity of SCN10A/Nav1.8, regulating its oligomerization and accelerating the recovery from inactivation (By similarity). {ECO:0000250|UniProtKB:Q9JK00, ECO:0000250|UniProtKB:Q9NY72}.
uniprot
proteins
mass_dalton
24789
uniprot
proteins
post_translational_modification
PTM: Intramolecular disulfide bonds favor the voltage-gated sodium channel oligomeric complex assembly. {ECO:0000250|UniProtKB:Q9NY72}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9NY72}.
uniprot
proteins
protein_family
Sodium channel auxiliary subunit SCN3B (TC 8.A.17) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NY72}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9NY72}.
uniprot
proteins
transmembrane_region
TRANSMEM 157..178; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NY72
uniprot
proteins