MAPRE3
entrez
22924
canonical
uniprot
Q9UPY8
canonical
ensembl
ENSG00000084764
resolver
ensp
ENSP00000233121
resolver
ensp
ENSP00000383915
resolver
ensp
ENSP00000770611
resolver
genesymbol
MAPRE3
resolver
hgnc
HGNC:6892
resolver
uniprot
B7WPK5
resolver
uniprot
O00265
resolver
uniprot
Q6FHB0
resolver
uniprot
Q6FI15
resolver
uniprot
Q9BZP7
resolver
uniprot
Q9BZP8
resolver
uniprot_entry
MARE3_HUMAN
resolver
uniprot_sec
B7WPK5
resolver
uniprot_sec
O00265
resolver
uniprot_sec
Q6FHB0
resolver
uniprot_sec
Q6FI15
resolver
uniprot_sec
Q9BZP7
resolver
uniprot_sec
Q9BZP8
resolver
amino_acid_sequence
MAVNVYSTSVTSENLSRHDMLAWVNDSLHLNYTKIEQLCSGAAYCQFMDMLFPGCVHLRKVKFQAKLEHEYIHNFKVLQAAFKKMGVDKIIPVEKLVKGKFQDNFEFIQWFKKFFDANYDGKDYNPLLARQGQDVAPPPNPGDQIFNKSKKLIGTAVPQRTSPTGPKNMQTSGRLSNVAPPCILRKNPPSARNGGHETDAQILELNQQLVDLKLTVDGLEKERDFYFSKLRDIELICQEHESENSPVISGIIGILYATEEGFAPPEDDEIEEHQQEDQDEY
uniprot
proteins
function
FUNCTION: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:19255245, PubMed:28814570). Promotes microtubule growth (PubMed:19255245, PubMed:28814570). May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:19255245, PubMed:28814570). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). {ECO:0000269|PubMed:19255245, ECO:0000269|PubMed:28814570}.
uniprot
proteins
mass_dalton
31982
uniprot
proteins
mutagenesis
MUTAGEN 226; /note="Y->A: Loss of localization of CAMSAP2 stretches to the Golgi apparatus; when associated with A-234."; /evidence="ECO:0000269|PubMed:28814570"; MUTAGEN 234; /note="E->A: Loss of localization of CAMSAP2 stretches to the Golgi apparatus; when associated with A-226."; /evidence="ECO:0000269|PubMed:28814570
uniprot
proteins
protein_family
MAPRE family
uniprot
proteins
pubmed
10188731
uniprot
proteins
pubmed
10644998
uniprot
proteins
pubmed
11161807
uniprot
proteins
pubmed
14514668
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17563362
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19146815
uniprot
proteins
pubmed
19255245
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21646404
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25217626
uniprot
proteins
pubmed
28814570
uniprot
proteins
pubmed
34996871
uniprot
proteins
pubmed
9233623
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10644998, ECO:0000269|PubMed:19255245, ECO:0000269|PubMed:28814570}. Note=Associated with the microtubule network. Detected at the plus end of microtubules. {ECO:0000269|PubMed:10644998, ECO:0000269|PubMed:19255245, ECO:0000269|PubMed:28814570}.
uniprot
proteins