PPT2
entrez
9374
canonical
uniprot
Q9UMR5
canonical
ensembl
ENSG00000168452
resolver
ensembl
ENSG00000206256
resolver
ensembl
ENSG00000206329
resolver
ensembl
ENSG00000221988
resolver
ensembl
ENSG00000227600
resolver
ensembl
ENSG00000228116
resolver
ensembl
ENSG00000231618
resolver
ensembl
ENSG00000236649
resolver
ensembl
ENSG00000258388
resolver
ensp
ENSP00000320528
resolver
ensp
ENSP00000354608
resolver
ensp
ENSP00000364279
resolver
ensp
ENSP00000372789
resolver
ensp
ENSP00000398462
resolver
ensp
ENSP00000406219
resolver
ensp
ENSP00000408333
resolver
ensp
ENSP00000410001
resolver
ensp
ENSP00000416505
resolver
ensp
ENSP00000431928
resolver
ensp
ENSP00000432308
resolver
ensp
ENSP00000432502
resolver
ensp
ENSP00000432964
resolver
ensp
ENSP00000433061
resolver
ensp
ENSP00000433323
resolver
ensp
ENSP00000434992
resolver
ensp
ENSP00000436963
resolver
enst
ENST00000383301
resolver
enst
ENST00000412651
resolver
enst
ENST00000414356
resolver
enst
ENST00000415972
resolver
enst
ENST00000423347
resolver
enst
ENST00000433748
resolver
enst
ENST00000476214
resolver
enst
ENST00000480383
resolver
enst
ENST00000483565
resolver
enst
ENST00000488579
resolver
enst
ENST00000490624
resolver
enst
ENST00000493809
resolver
enst
ENST00000496937
resolver
enst
ENST00000527704
resolver
genesymbol
PPT2
resolver
hgnc
HGNC:9326
resolver
uniprot
A2ABC9
resolver
uniprot
A2ABD1
resolver
uniprot
A2ARM7
resolver
uniprot
A2BFH7
resolver
uniprot
A2BFH9
resolver
uniprot
A2BFI2
resolver
uniprot
A8K9L4
resolver
uniprot
B0S868
resolver
uniprot
G8JLE1
resolver
uniprot
O14799
resolver
uniprot
Q0P6K0
resolver
uniprot
Q5JP13
resolver
uniprot
Q5JP14
resolver
uniprot
Q5JQF0
resolver
uniprot
Q5SSX4
resolver
uniprot
Q5SSX5
resolver
uniprot
Q5SSX6
resolver
uniprot
Q5STJ4
resolver
uniprot
Q5STJ5
resolver
uniprot
Q5STJ6
resolver
uniprot
Q6FI80
resolver
uniprot
Q99945
resolver
uniprot_entry
PPT2_HUMAN
resolver
uniprot_sec
A2ABC9
resolver
uniprot_sec
A2ABD1
resolver
uniprot_sec
A2ARM7
resolver
uniprot_sec
A2BFH7
resolver
uniprot_sec
A2BFH9
resolver
uniprot_sec
A2BFI2
resolver
uniprot_sec
A8K9L4
resolver
uniprot_sec
B0S868
resolver
uniprot_sec
G8JLE1
resolver
uniprot_sec
O14799
resolver
uniprot_sec
Q0P6K0
resolver
uniprot_sec
Q5JP13
resolver
uniprot_sec
Q5JP14
resolver
uniprot_sec
Q5JQF0
resolver
uniprot_sec
Q5SSX4
resolver
uniprot_sec
Q5SSX5
resolver
uniprot_sec
Q5SSX6
resolver
uniprot_sec
Q5STJ4
resolver
uniprot_sec
Q5STJ5
resolver
uniprot_sec
Q5STJ6
resolver
uniprot_sec
Q6FI80
resolver
uniprot_sec
Q99945
resolver
amino_acid_sequence
MLGLCGQRLPAAWVLLLLPFLPLLLLAAPAPHRASYKPVIVVHGLFDSSYSFRHLLEYINETHPGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMAKAPQGVHLICYSQGGLVCRALLSVMDDHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRICYSPWGQEFSICNYWHDPHHDDLYLNASSFLALINGERDHPNATVWRKNFLRVGHLVLIGGPDDGVITPWQSSFFGFYDANETVLEMEEQLVYLRDSFGLKTLLARGAIVRCPMAGISHTAWHSNRTLYETCIEPWLS
uniprot
proteins
ec_number
3.1.2.2
uniprot
proteins
function
FUNCTION: Catalyzes the cleavage of thioester bonds from S-palmitoyl-CoA or S-palmitoyl-N-acetylcysteamine (unbranched structures) but does not have activity against palmitoylcysteine or palmitoylated proteins, branched structures or bulky head groups. Conversely, hydrolyzes both long and short chain fatty acyl-CoA substrate. {ECO:0000269|PubMed:10417332, ECO:0000269|PubMed:12855696, ECO:0000269|PubMed:9341199}.; FUNCTION: [Isoform 2]: Catalytically inactive due to lack of active site His-283. {ECO:0000269|PubMed:12855696}.
uniprot
proteins
mass_dalton
34225
uniprot
proteins
mutagenesis
MUTAGEN 111; /note="S->A: Abolishes palmitoyl-CoA hydrolase activity."; /evidence="ECO:0000269|PubMed:12855696"; MUTAGEN 228; /note="D->A: Abolishes palmitoyl-CoA hydrolase activity."; /evidence="ECO:0000269|PubMed:12855696"; MUTAGEN 283; /note="H->A: Abolishes palmitoyl-CoA hydrolase activity."; /evidence="ECO:0000269|PubMed:12855696"; MUTAGEN 287; /note="H->A: No effect palmitoyl-CoA hydrolase activity."; /evidence="ECO:0000269|PubMed:12855696
uniprot
proteins
protein_family
Palmitoyl-protein thioesterase family
uniprot
proteins
pubmed
10051407
uniprot
proteins
pubmed
10417332
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12855696
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9341199
uniprot
proteins
sequence_length
302
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:9341199}.
uniprot
proteins