Nle1
entrez
217011
canonical
uniprot
Q8VEJ4
canonical
ensembl
ENSMUSG00000020692
resolver
ensp
ENSMUSP00000099502
resolver
enst
ENSMUST00000103213
resolver
genesymbol
Nle1
resolver
uniprot
B1ARD5
resolver
uniprot
Q3URT5
resolver
uniprot_entry
NLE1_MOUSE
resolver
uniprot_entry
Q3URT5_MOUSE
resolver
uniprot_sec
B1ARD5
resolver
amino_acid_sequence
MAAAVVEEAAAGDVQRLLVQFQDEGGQLLGSPFDVPVDITPDKLQLVCNALLAQEEPLPLAFYVHDAEIVSSLGKTLESQSVETEKIVDIIYQPQAVFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQVLLWDPSTGLQVGRTLTGHSKWITGLSWEPLHMNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEATVNAQDLQGSLKELKERASSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR
uniprot
proteins
function
FUNCTION: Plays a role in regulating Notch activity (Probable). Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival. {ECO:0000269|PubMed:16611995, ECO:0000269|PubMed:23231322, ECO:0000305}.
uniprot
proteins
mass_dalton
53134
uniprot
proteins
mutagenesis
MUTAGEN 163; /note="S->P: In l11Jus4; embryos survive through implantation but fail prior to gastrulation."; /evidence="ECO:0000269|PubMed:23231322"; MUTAGEN 396; /note="I->S: In l11Jus1; embryos survive through implantation but fail prior to gastrulation. Cdkna1 expression is up-regulated while expression of several Wnt pathway members is down-regulated."; /evidence="ECO:0000269|PubMed:23231322
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16611995
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23231322
uniprot
proteins
sequence_length
485
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
uniprot
proteins