Lacc1
entrez
210808
canonical
uniprot
Q8BZT9
canonical
ensembl
ENSMUSG00000044350
resolver
ensp
ENSMUSP00000059173
resolver
enst
ENSMUST00000062789
resolver
genesymbol
Lacc1
resolver
genesymbol_syn
Famin
resolver
uniprot
Q14AQ3
resolver
uniprot
Q3U600
resolver
uniprot_entry
LACC1_MOUSE
resolver
uniprot_sec
Q14AQ3
resolver
uniprot_sec
Q3U600
resolver
amino_acid_sequence
MAEAVLIDLSGLQLNAQKNCHETLLETLDGIHYHHAPKAKFLCIICCRNASKEKDGEYGLCELEAGNGFSRLAGKFETVSHPCLAASLYTIKQKIDEENLSCIKVIVPEHRKLLMKAYVGQLFTEVYEFEFEDLQGAWRDSLLKPSTGINVTTTQELEDIQHEIETYLRSLPALKGDLTIVTSPLIPDNFLHGFTTRTGGISSVPTLSSLNLFSSSKRRDPKVVVQENVRRLANAAGFNAEKFYRIKTDHASEVWVMGKKEPESYDGIVTNQRGVTITALGADCIPIVFADPVKKACGVAHSGWKGTLLGVAMATVNAMIAEYGCDVEDIIVVLGPSVGSCCFTLPKESAVSFHSLHPSCVRHFDSPRPYVDIRKATRILLERGGILPQNIQDQKEDLDLCTSCHPEKFFSHVRDGLNFGTQIGFISLRE
uniprot
proteins
ec_number
2.4.2.1
uniprot
proteins
ec_number
2.4.2.28
uniprot
proteins
ec_number
3.5.4.4
uniprot
proteins
ec_number
4.3.3.-
uniprot
proteins
function
FUNCTION: Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine (By similarity). Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (By similarity). Also has adenosine deaminase activity (By similarity). Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages (PubMed:27478939, PubMed:31978345). Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface (PubMed:31978345). The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity (PubMed:31978345). Participates in pattern recognition receptor-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance (By similarity). Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR) (By similarity). Does not show laccase activity (By similarity). Component of L-arginine metabolism in activated macrophages supporting anti-inflammatory and antibacterial macrophage effector functions. Cleaves L-citrulline, a product of L-arginine metabolized via NOS2, to yield isocyanate, a reactive carbonyl species-like cytotoxin, and L-ornithine, a precursor in polyamine biosynthesis. Through L-ornithine controls cellular polyamine pools likely triggering polyamine-mediated proinflammatory cytokine suppression and autophagy stimulation (PubMed:35978195). Directly interacts with components of autophagy machinery to regulate macrophage metabolism and bacterial phagocytosis. Acts downstream of the energy sensor AMP-activated protein kinase (AMPK) to promote autophagy associated to lipid droplets generation providing fatty acids for mitochondrial respiration (By similarity). {ECO:0000250|UniProtKB:Q8IV20, ECO:0000269|PubMed:27478939, ECO:0000269|PubMed:31978345, ECO:0000269|PubMed:35978195}.
uniprot
proteins
mass_dalton
47514
uniprot
proteins
mutagenesis
MUTAGEN 254; /note="V->I: Reduced function."; /evidence="ECO:0000269|PubMed:27478939"; MUTAGEN 284; /note="C->R: Complete loss of function. Results in increased proinflammatory cytokine production and decreased antibacterial response upon S. Typhimurium infection."; /evidence="ECO:0000269|PubMed:27478939, ECO:0000269|PubMed:35978195
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues. {ECO:0000250|UniProtKB:Q8IV20}.
uniprot
proteins
protein_family
PgeF/LACC1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
27478939
uniprot
proteins
pubmed
30510070
uniprot
proteins
pubmed
31978345
uniprot
proteins
pubmed
35978195
uniprot
proteins
sequence_length
430
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30510070}. Nucleus {ECO:0000269|PubMed:30510070}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8IV20}. Peroxisome {ECO:0000250|UniProtKB:Q8IV20}. Note=Upon stimulation of the pattern-recognition receptor (PRR) NOD2, localizes to the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q8IV20}.
uniprot
proteins