Atp6v0e1
entrez
11974
canonical
uniprot
Q9CQD8
canonical
ensembl
ENSMUSG00000015575
resolver
ensp
ENSMUSP00000015719
resolver
ensp
ENSMUSP00000127552
resolver
enst
ENSMUST00000015719
resolver
enst
ENSMUST00000167352
resolver
genesymbol
Atp6v0e1
resolver
genesymbol_syn
Atp6v0e
resolver
uniprot_entry
VA0E1_MOUSE
resolver
amino_acid_sequence
MAYHGLTVPLIVMSVFWGFVGLLVPWFIPKGPNRGVIITMLVTCSVCCYLFWLIAILAQLNPLFGPQLKNETIWYLKYHWP
uniprot
proteins
function
FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). {ECO:0000250|UniProtKB:O15342, ECO:0000250|UniProtKB:Q2KIB5}.
uniprot
proteins
mass_dalton
9340
uniprot
proteins
protein_family
V-ATPase e1/e2 subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
81
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins