Prdx2
entrez
21672
canonical
uniprot
Q61171
canonical
ensembl
ENSMUSG00000005161
resolver
ensp
ENSMUSP00000005292
resolver
ensp
ENSMUSP00000105355
resolver
ensp
ENSMUSP00000105356
resolver
ensp
ENSMUSP00000126451
resolver
enst
ENSMUST00000005292
resolver
enst
ENSMUST00000109733
resolver
enst
ENSMUST00000109734
resolver
enst
ENSMUST00000164807
resolver
genesymbol
Prdx2
resolver
genesymbol_syn
Tdpx1
resolver
genesymbol_syn
Tpx
resolver
uniprot
O88376
resolver
uniprot
Q5M9N9
resolver
uniprot
Q60796
resolver
uniprot
Q9CWJ4
resolver
uniprot
Q9DB49
resolver
uniprot_entry
PRDX2_MOUSE
resolver
uniprot_entry
Q5M9N9_MOUSE
resolver
uniprot_sec
O88376
resolver
uniprot_sec
Q60796
resolver
uniprot_sec
Q9CWJ4
resolver
uniprot_sec
Q9DB49
resolver
amino_acid_sequence
MASGNAQIGKSAPDFTATAVVDGAFKEIKLSDYRGKYVVLFFYPLDFTFVCPTEIIAFSDHAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTKSLSQNYGVLKNDEGIAYRGLFIIDAKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN
uniprot
proteins
ec_number
1.11.1.24
uniprot
proteins
function
FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). {ECO:0000250|UniProtKB:P32119}.
uniprot
proteins
mass_dalton
21779
uniprot
proteins
post_translational_modification
PTM: The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner. {ECO:0000250|UniProtKB:P32119, ECO:0000250|UniProtKB:Q06830}.; PTM: Acetylation increases resistance to transition to high molecular-mass complexes. Deacetylated by HDAC6 which decreases reducing activity. {ECO:0000250|UniProtKB:P32119}.
uniprot
proteins
protein_family
AhpC/Prx1 subfamily
uniprot
proteins
protein_family
Peroxiredoxin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17141802
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9115640
uniprot
proteins
pubmed
9714804
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P32119}.
uniprot
proteins