Hao1
entrez
15112
canonical
uniprot
Q9WU19
canonical
ensembl
ENSMUSG00000027261
resolver
ensp
ENSMUSP00000028704
resolver
enst
ENSMUST00000028704
resolver
genesymbol
Hao1
resolver
uniprot
Q3UEE8
resolver
uniprot_entry
HAOX1_MOUSE
resolver
uniprot_entry
Q3UEE8_MOUSE
resolver
amino_acid_sequence
MLPRLVCISDYEQHVRSVLQKSVYDYYRSGANDQETLADNIQAFSRWKLYPRMLRNVADIDLSTSVLGQRVSMPICVGATAMQCMAHVDGELATVRACQTMGTGMMLSSWATSSIEEVAEAGPEALRWMQLYIYKDREISRQIVKRAEKQGYKAIFVTVDTPYLGNRIDDVRNRFKLPPQLRMKNFETNDLAFSPKGNFGDNSGLAEYVAQAIDPSLSWDDITWLRRLTSLPIVVKGILRGDDAKEAVKHGVDGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIIWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI
uniprot
proteins
ec_number
1.1.3.15
uniprot
proteins
ec_number
1.2.3.5
uniprot
proteins
function
FUNCTION: Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate (PubMed:9891009). The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine-glyoxylate aminotransferase for the peroxisomal synthesis of glycine; this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones (By similarity). Can also catalyze the oxidation glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate (By similarity). Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2 (PubMed:9891009). {ECO:0000250|UniProtKB:Q9UJM8, ECO:0000269|PubMed:9891009}.
uniprot
proteins
mass_dalton
41001
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; glycine biosynthesis. {ECO:0000250|UniProtKB:Q9UJM8}.
uniprot
proteins
protein_family
FMN-dependent alpha-hydroxy acid dehydrogenase family
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
9891009
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000250|UniProtKB:Q9UJM8}.
uniprot
proteins