Nlrp2
entrez
232827
canonical
uniprot
Q4PLS0
canonical
ensembl
ENSMUSG00000035177
resolver
ensp
ENSMUSP00000045077
resolver
enst
ENSMUST00000045022
resolver
genesymbol
Nlrp2
resolver
genesymbol_syn
Nalp2
resolver
uniprot
F6W5A2
resolver
uniprot_entry
F6W5A2_MOUSE
resolver
uniprot_entry
Q4PLS0_MOUSE
resolver
amino_acid_sequence
MEHFDPLGFNLKDVLRKLDKTELNNFKRTLRSCSLPDTMKQINKLTMDLANGAQLAEILTDHCPSAWIKRVTVQILEEINRVDLAELVVKQIEEAVLKVPEEKVSSKPREPSGTLTFPWNFVQGAKRPEDKQKEEWKTRYTAKWKQNFWPKCNKEIYVVTESYKTLLALCNPKIETPFAHAIVLHGPPGSGKTTMAKQLMLEWSESKQAQIFSCAFYISCREVNNTKPCTFAHLLSMDNPSWRDCVIRDLILGKEFLFVVDGFDELTFPAGALIRDLCGDWNTVKPVEVLLGSLLKRKMAPHATLLVTTRTQSLHQIFVMMDQPLLVETLGFLEQEKQEYFQKYFEDEEGEEEDKGEGKALRALKEVRCNADLYQMASLPTACGIFCLCLELRMKKGEDLSLTCQTYTSMFLNFLCEVFSSETCEDHLNEEFQILFKKICILAANSLLEQVPILCEEDFLTLKLNLNNLHPMVCRHILFKDSSSTHCLSFICLGIQQLLAAIIFVQELGQESKGVSKYSIQNMLSREARLKNPDLSGLLPFVFGLLNETRIQELKTTFGCQISTEVKRKFLECESGENKPLLLLMNMQEILSCLYESQEEGFVKEAMVLFEDISLHLKTSTDLIHASFCLKNSQNLQTMSLKVEKAVFPENVAALESTAKHQRSPDEQRMLTFWTDFCDTFNSNKKLVFLDIHESFLNSSALEILCEKLPSASCCLQKVVLKNISPDDAYEKLCLIFNGYKTISHLILQGGNLDSMHHSLCEVLKNPACNLKFLSLGSCSTAAQKWDDFFPVLKVNQSLIFLDLTDNSLLDKSAKLLCNIWKEPKCILQRVSLENCQLTEACCKDLSSVLMVSRTLTHLSLANNKLGDNGVKNLCESISCTECNLQTLVLWSCNITNAGCHYLSKMLKQTLSLKHLDLGLNRIGTKGAKFLCEALKNPKSKLKSLWLCGCSITPLNCQDFSETLRSNKSLNTLDLSQNVLGTDAIKTFCEALKLQICPLQMLRLKFDEAKPSIQNLIQEMKVSHPQLRISSDQVDLKNPPLPHFIF
uniprot
proteins
function
FUNCTION: Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development (PubMed:28317850). The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (By similarity). Cytoplasmic lattices are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained state, regulating their availability for early embryonic development (By similarity). Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF (By similarity). When associated with PYCARD, activates CASP1, leading to the secretion of mature pro-inflammatory cytokine IL1B (By similarity). May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of pro-inflammatory caspases (By similarity). {ECO:0000250|UniProtKB:Q9NX02, ECO:0000269|PubMed:28317850}.
uniprot
proteins
mass_dalton
118641
uniprot
proteins
protein_family
NLRP family
uniprot
proteins
pubmed
16085473
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22295082
uniprot
proteins
pubmed
27881734
uniprot
proteins
pubmed
28317850
uniprot
proteins
pubmed
41454780
uniprot
proteins
sequence_length
1046
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22295082, ECO:0000269|PubMed:28317850}. Nucleus {ECO:0000269|PubMed:22295082}. Note=localized in the cytoplasm, nucleus and close to nuclear pores in the oocytes. {ECO:0000269|PubMed:22295082}.
uniprot
proteins