TANGO2
entrez
128989
canonical
uniprot
Q6ICL3
canonical
ensembl
ENSG00000183597
resolver
ensp
ENSP00000332721
resolver
ensp
ENSP00000381122
resolver
ensp
ENSP00000382706
resolver
ensp
ENSP00000384827
resolver
ensp
ENSP00000385662
resolver
ensp
ENSP00000389797
resolver
ensp
ENSP00000391262
resolver
ensp
ENSP00000396182
resolver
ensp
ENSP00000402926
resolver
ensp
ENSP00000403645
resolver
ensp
ENSP00000522364
resolver
ensp
ENSP00000522365
resolver
ensp
ENSP00000522368
resolver
ensp
ENSP00000522369
resolver
ensp
ENSP00000627835
resolver
ensp
ENSP00000661823
resolver
ensp
ENSP00000721222
resolver
enst
ENST00000399807
resolver
enst
ENST00000420290
resolver
enst
ENST00000447208
resolver
enst
ENST00000852309
resolver
genesymbol
TANGO2
resolver
genesymbol_syn
C22orf25
resolver
hgnc
HGNC:25439
resolver
uniprot
A0A0A0MSI5
resolver
uniprot
A0A0A0MSM1
resolver
uniprot
A8K1E7
resolver
uniprot
A8MUE9
resolver
uniprot
A8MWT1
resolver
uniprot
B7WNV6
resolver
uniprot
B7Z4A5
resolver
uniprot
B7Z4V5
resolver
uniprot
B7Z583
resolver
uniprot
B7Z730
resolver
uniprot
B7Z9Q5
resolver
uniprot
D3DX23
resolver
uniprot
Q8IW05
resolver
uniprot
Q8NAL0
resolver
uniprot
Q8TCS0
resolver
uniprot
Q96M16
resolver
uniprot_entry
A0A0A0MSI5_HUMAN
resolver
uniprot_entry
A0A0A0MSM1_HUMAN
resolver
uniprot_entry
A8K1E7_HUMAN
resolver
uniprot_entry
A8MWT1_HUMAN
resolver
uniprot_entry
B7Z4A5_HUMAN
resolver
uniprot_entry
B7Z4V5_HUMAN
resolver
uniprot_entry
B7Z9Q5_HUMAN
resolver
uniprot_entry
TNG2_HUMAN
resolver
uniprot_sec
A8MUE9
resolver
uniprot_sec
B7WNV6
resolver
uniprot_sec
B7Z583
resolver
uniprot_sec
B7Z730
resolver
uniprot_sec
D3DX23
resolver
uniprot_sec
Q8IW05
resolver
uniprot_sec
Q8NAL0
resolver
uniprot_sec
Q8TCS0
resolver
uniprot_sec
Q96M16
resolver
amino_acid_sequence
MCIIFFKFDPRPVSKNAYRLILAANRDEFYSRPSKLADFWGNNNEILSGLDMEEGKEGGTWLGISTRGKLAALTNYLQPQLDWQARGRGELVTHFLTTDVDSLSYLKKVSMEGHLYNGFNLIAADLSTAKGDVICYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLCFGKQLFLEAVERSQALPKDVLIASLLDVLNNEEAQLPDPAIEDQGGEYVQPMLSKYAAVCVRCPGYGTRTNTIILVDADGHVTFTERSMMDKDLSHWETRTYEFTLQS
uniprot
proteins
disease_involvement
DISEASE: Metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration (MECRCN) [MIM:616878]: An autosomal recessive disorder characterized by metabolic encephalomyopathic crises, hypoglycemia, hyperammonemia, episodic rhabdomyolysis, susceptibility to life-threatening cardiac tachyarrhythmias, developmental delay, intellectual disability, and mild diffuse cerebral atrophy. {ECO:0000269|PubMed:26805781, ECO:0000269|PubMed:26805782, ECO:0000269|PubMed:30245509, ECO:0000269|PubMed:31276219, ECO:0000269|PubMed:31339582, ECO:0000269|PubMed:32909282, ECO:0000269|PubMed:32929747, ECO:0000269|PubMed:33342685}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May be involved in lipid homeostasis. {ECO:0000269|PubMed:36961129}.
uniprot
proteins
mass_dalton
30937
uniprot
proteins
mutagenesis
MUTAGEN 1..40; /note="Missing: Abolishes mitochondrial localization."; /evidence="ECO:0000269|PubMed:32909282
uniprot
proteins
protein_family
Tango2 family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
26805781
uniprot
proteins
pubmed
26805782
uniprot
proteins
pubmed
30245509
uniprot
proteins
pubmed
30327536
uniprot
proteins
pubmed
31276219
uniprot
proteins
pubmed
31339582
uniprot
proteins
pubmed
32909282
uniprot
proteins
pubmed
32929747
uniprot
proteins
pubmed
33342685
uniprot
proteins
pubmed
35197517
uniprot
proteins
pubmed
36961129
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31276219, ECO:0000269|PubMed:32909282, ECO:0000269|PubMed:36961129}. Mitochondrion {ECO:0000269|PubMed:32909282, ECO:0000269|PubMed:35197517, ECO:0000269|PubMed:36961129}. Golgi apparatus {ECO:0000269|PubMed:26805781}. Note=Localizes predominantly to mitochondrion. Detected in close proximity to endoplasmic reticulum and lipid droplets. {ECO:0000269|PubMed:36961129}.
uniprot
proteins