Serinc3
entrez
26943
canonical
uniprot
Q9QZI9
canonical
ensembl
ENSMUSG00000017707
resolver
ensp
ENSMUSP00000017851
resolver
ensp
ENSMUSP00000293662
resolver
ensp
ENSMUSP00000293663
resolver
ensp
ENSMUSP00000293668
resolver
ensp
ENSMUSP00000293669
resolver
enst
ENSMUST00000017851
resolver
genesymbol
Serinc3
resolver
genesymbol_syn
Aigp1
resolver
genesymbol_syn
Diff33
resolver
genesymbol_syn
Tde1
resolver
genesymbol_syn
Tms1
resolver
uniprot
Q3U7C6
resolver
uniprot
Q62310
resolver
uniprot
Q8BSP9
resolver
uniprot
Q8CFD3
resolver
uniprot
Q91VN9
resolver
uniprot_entry
SERC3_MOUSE
resolver
uniprot_sec
Q3U7C6
resolver
uniprot_sec
Q62310
resolver
uniprot_sec
Q8BSP9
resolver
uniprot_sec
Q8CFD3
resolver
uniprot_sec
Q91VN9
resolver
amino_acid_sequence
MGAVLGVFSLASWVPCLCSGASCLLCSCCPISKNSTVTRLIYAFILFLGTIVSCIMMTEGIQTQLKKIPGFCEGGFQIKMVDTKAEKDCDVLVGFKAVYRINFAVAIFFFAFFLLMLKVKTSKDPRAAVHNGFWFFKIAAIIGIMIGSFYIPGGSFTEVWFVAGMLGASFFIIIQLVLLVDMAHSWNELWVNRMEEGNPRLWYAALLSFTSLFYILSIVFAALLYVFYTKPDDCTENKVFISLNLIFCVAVSIVSILPKVQEHQPRSGLLQSSIITLYTLYLTWSAMTNEPERSCNPSLMSIITHLTSPTVSPANSTTLAPAYAPPSQSGHFMNLDDIWGLIIFVFCLIYSSFRTSSNSQVNKLTLSGSDSVILGDTTNGANDEEDGQPRRAVDNEKEGVQYSYSFFHLMLCCASLYIMMTITSWYSPDAKFQKVSSKWLAVWFKMGSSWLCLLLYLWTLVAPLVLTGRDFS
uniprot
proteins
function
FUNCTION: Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in gammaretroviral surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to loss of infectivity. {ECO:0000250|UniProtKB:Q13530}.
uniprot
proteins
mass_dalton
52623
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:12486168}.
uniprot
proteins
protein_family
TDE1 family
uniprot
proteins
pubmed
10637174
uniprot
proteins
pubmed
12486168
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7894057
uniprot
proteins
sequence_length
472
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12486168}; Multi-pass membrane protein {ECO:0000269|PubMed:12486168}. Golgi apparatus membrane {ECO:0000269|PubMed:12486168}; Multi-pass membrane protein {ECO:0000269|PubMed:12486168}. Note=Localizes to the cell membrane, where it is efficiently incorporated into budding gammaretrovirus virions and impairs subsequent virion penetration of susceptible target cells (By similarity). {ECO:0000250|UniProtKB:Q86VE9}.
uniprot
proteins
transmembrane_region
TRANSMEM 97..117; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 133..153; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 159..179; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 239..259; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 330..350; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 406..426; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 446..466; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins