Bmp10
entrez
12154
canonical
uniprot
Q9R229
canonical
ensembl
ENSMUSG00000030046
resolver
ensp
ENSMUSP00000032125
resolver
enst
ENSMUST00000032125
resolver
genesymbol
Bmp10
resolver
uniprot
A6H6S5
resolver
uniprot
Q9Z1V8
resolver
uniprot_entry
BMP10_MOUSE
resolver
uniprot_sec
A6H6S5
resolver
uniprot_sec
Q9Z1V8
resolver
amino_acid_sequence
MGSLVLPLSAVFCLVAHSASGSPIMGLEQSPLEEDMPFFDDIFTEQDGIDFNTLLQSMKNEFLKTLNLSDIPVQDTGRVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVTFNGLRKYPLLFNVSIPHHEEVVMAELRLYTLVQRDRMMYDGVDRKITIFEVLESADGSEEERSMLVLVSTEIYGTNSEWETFDVTDATRRWQKSGPSTHQLEIHIESRQNQAEDTGRGQLEIDMSAQNKHDPLLVVFSDDQSNDKEQKEELNELITHEQDLDLDSDAFFSGPDEEALLQMRSNMIDDSSARIRRNAKGNYCKKTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLDPISILYLDKGVVTYKFKYEGMAVSECGCR
uniprot
proteins
function
FUNCTION: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines (By similarity). {ECO:0000250|UniProtKB:O95393, ECO:0000269|PubMed:15073151, ECO:0000269|PubMed:15109497, ECO:0000269|PubMed:16798733}.
uniprot
proteins
mass_dalton
47888
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
10072785
uniprot
proteins
pubmed
15073151
uniprot
proteins
pubmed
15109497
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16798733
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21737454
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins