NABP2
entrez
79035
canonical
uniprot
Q9BQ15
canonical
ensembl
ENSG00000139579
resolver
ensp
ENSP00000267023
resolver
ensp
ENSP00000369545
resolver
ensp
ENSP00000552113
resolver
ensp
ENSP00000552114
resolver
ensp
ENSP00000629421
resolver
genesymbol
NABP2
resolver
genesymbol_syn
OBFC2B
resolver
genesymbol_syn
SSB1
resolver
hgnc
HGNC:28412
resolver
uniprot
A6NDF8
resolver
uniprot
Q6XYC8
resolver
uniprot_entry
SOSB1_HUMAN
resolver
uniprot_sec
A6NDF8
resolver
uniprot_sec
Q6XYC8
resolver
amino_acid_sequence
MTTETFVKDIKPGLKNLNLIFIVLETGRVTKTKDGHEVRTCKVADKTGSINISVWDDVGNLIQPGDIIRLTKGYASVFKGCLTLYTGRGGDLQKIGEFCMVYSEVPNFSEPNPEYSTQQAPNKAVQNDSNPSASQPTTGPSAASPASENQNGNGLSAPPGPGGGPHPPHTPSHPPSTRITRSQPNHTPAGPPGPSSNPVSNGKETRRSSKR
uniprot
proteins
function
FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint (PubMed:25249620). In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501, ECO:0000269|PubMed:25249620}.
uniprot
proteins
mass_dalton
22338
uniprot
proteins
mutagenesis
MUTAGEN 117; /note="T->A: Loss of phosphorylation by ATM."; /evidence="ECO:0000269|PubMed:18449195"; MUTAGEN 117; /note="T->E: Enhances ATM-dependent signaling."; /evidence="ECO:0000269|PubMed:18449195
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ATM in response to DNA damage. Phosphorylation prevents degradation by the proteasome, hence stabilization of the protein and accumulation within cells. {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:25249620}.; PTM: Ubiquitinated in a FBXL5-dependent manner, leading to proteasomal degradation. {ECO:0000269|PubMed:25249620}.
uniprot
proteins
protein_family
SOSS-B family
uniprot
proteins
protein_family
SOSS-B1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
18449195
uniprot
proteins
pubmed
19605351
uniprot
proteins
pubmed
19683501
uniprot
proteins
pubmed
21659603
uniprot
proteins
pubmed
25249620
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment.
uniprot
proteins