Nectin1
entrez
58235
canonical
uniprot
Q9JKF6
canonical
ensembl
ENSMUSG00000032012
resolver
ensp
ENSMUSP00000034510
resolver
enst
ENSMUST00000034510
resolver
genesymbol
Nectin1
resolver
genesymbol_syn
Hvec
resolver
genesymbol_syn
Prr1
resolver
genesymbol_syn
Pvrl1
resolver
uniprot
Q6P9M9
resolver
uniprot
Q9ERL5
resolver
uniprot
Q9JI17
resolver
uniprot_entry
NECT1_MOUSE
resolver
uniprot_sec
Q6P9M9
resolver
uniprot_sec
Q9ERL5
resolver
uniprot_sec
Q9JI17
resolver
amino_acid_sequence
MARMGLAGAAGRWWGLALGLTAFFLPGTHTQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKASNGSKQNMAIYNPTMGVSVLPPYEKRVEFLRPSFIDGTIRLSGLELEDEGMYICEFATFPTGNRESQLNLTVMAKPTNWIEGTRAVLRARKGQDDKVLVATCTSANGKPPSAVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHRQSLACIVNYHLDRFRESLTLNVQYEPEVTIEGFDGNWYLQRTDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFRGPITYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPTPEHGRRAGQMPTAIIGGVAGSVLLVLIVVGGIIVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPDDSDDEKKAGPLGGSSYEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV
uniprot
proteins
function
FUNCTION: Cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system (PubMed:11827984, PubMed:15328010, PubMed:18703497, PubMed:21798896, PubMed:22955284). Acts by forming homophilic or heterophilic trans-dimers (PubMed:11827984). Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4 (PubMed:11827984, PubMed:21798896). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (PubMed:15328010). Involved in synaptogegesis (PubMed:11827984). Has some neurite outgrowth-promoting activity (PubMed:22955284). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN3: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (PubMed:21798896). Required for enamel mineralization (PubMed:18703497). {ECO:0000269|PubMed:11827984, ECO:0000269|PubMed:15328010, ECO:0000269|PubMed:18703497, ECO:0000269|PubMed:21798896, ECO:0000269|PubMed:22955284}.; FUNCTION: (Microbial infection) Acts as a receptor for pseudorabies virus/PRV. {ECO:0000269|PubMed:38030279}.
uniprot
proteins
mass_dalton
57035
uniprot
proteins
mutagenesis
MUTAGEN 129; /note="F->A: Abolished binding to pseudorabies virus glycoprotein D; knockin mice are resistant infection by pseudorabies virus."; /evidence="ECO:0000269|PubMed:38030279
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
10744716
uniprot
proteins
pubmed
10781093
uniprot
proteins
pubmed
11090177
uniprot
proteins
pubmed
11827984
uniprot
proteins
pubmed
15328010
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15728677
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18703497
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21798896
uniprot
proteins
pubmed
22955284
uniprot
proteins
pubmed
38030279
uniprot
proteins
sequence_length
515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11827984, ECO:0000269|PubMed:21798896}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000269|PubMed:15328010, ECO:0000269|PubMed:15728677}. Presynaptic cell membrane {ECO:0000269|PubMed:11827984}; Single-pass type I membrane protein {ECO:0000255}. Note=In the auditory epithelium, specificaly localizes to the apical side of the lateral membranes of hair cells. {ECO:0000269|PubMed:21798896}.
uniprot
proteins
transmembrane_region
TRANSMEM 355..375; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins