PGAP6
entrez
58986
canonical
uniprot
Q9HCN3
canonical
ensembl
ENSG00000129925
resolver
ensp
ENSP00000250930
resolver
ensp
ENSP00000401338
resolver
enst
ENST00000250930
resolver
enst
ENST00000431232
resolver
genesymbol
PGAP6
resolver
genesymbol_syn
TMEM6
resolver
genesymbol_syn
TMEM8
resolver
genesymbol_syn
TMEM8A
resolver
hgnc
HGNC:17205
resolver
uniprot
D3DU49
resolver
uniprot
K4DI83
resolver
uniprot
Q4TT35
resolver
uniprot
Q8WU24
resolver
uniprot
Q96S25
resolver
uniprot
Q9BR03
resolver
uniprot
Q9BT97
resolver
uniprot
Q9H7B9
resolver
uniprot_entry
K4DI83_HUMAN
resolver
uniprot_entry
PGAP6_HUMAN
resolver
uniprot_sec
D3DU49
resolver
uniprot_sec
Q4TT35
resolver
uniprot_sec
Q8WU24
resolver
uniprot_sec
Q96S25
resolver
uniprot_sec
Q9BR03
resolver
uniprot_sec
Q9BT97
resolver
uniprot_sec
Q9H7B9
resolver
amino_acid_sequence
MGRAGTGTGGEAVAAVVAGPLLLLLLARPPPASAGYSGKSEVGLVSEHFSQAPQRLSFYSWYGSARLFRFRVPPDAVLLRWLLQVSRESGAACTDAEITVHFRSGAPPVINPLGTSFPDDTAVQPSFQVGVPLSTTPRSNASVNVSHPAPGDWFVAAHLPPSSQKIELKGLAPTCAYVFQPELLVTRVVEISIMEPDVPLPQTLLSHPSYLKVFVPDYTRELLLELRDCVSNGSLGCPVRLTVGPVTLPSNFQKVLTCTGAPWPCRLLLPSPPWDRWLQVTAESLVGPLGTVAFSAVAALTACRPRSVTIQPLLQSSQNQSFNASSGLLSPSPDHQDLGRSGRVDRSPFCLTNYPVTREDMDVVSVHFQPLDRVSVRVCSDTPSVMRLRLNTGMDSGGSLTISLRANKTEMRNETVVVACVNAASPFLGFNTSLNCTTAFFQGYPLSLSAWSRRANLIIPYPETDNWYLSLQLMCPENAEDCEQAVVHVETTLYLVPCLNDCGPYGQCLLLRRHSYLYASCSCKAGWRGWSCTDNSTAQTVAQQRAATLLLTLSNLMFLAPIAVSVRRFFLVEASVYAYTMFFSTFYHACDQPGEAVLCILSYDTLQYCDFLGSGAAIWVTILCMARLKTVLKYVLFLLGTLVIAMSLQLDRRGMWNMLGPCLFAFVIMASMWAYRCGHRRQCYPTSWQRWAFYLLPGVSMASVGIAIYTSMMTSDNYYYTHSIWHILLAGSAALLLPPPDQPAEPWACSQKFPCHYQICKNDREELYAVT
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP CRIPTO, but not CFC1, at the cell surface. Shedding of CRIPTO modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401). {ECO:0000269|PubMed:26858401, ECO:0000269|PubMed:27835684, ECO:0000269|PubMed:27881714}.
uniprot
proteins
mass_dalton
84761
uniprot
proteins
mutagenesis
MUTAGEN 584; /note="S->A: No effect."; /evidence="ECO:0000269|PubMed:27881714"; MUTAGEN 588; /note="H->A: Abolishes shedding of CRIPTO."; /evidence="ECO:0000269|PubMed:27881714"; MUTAGEN 610; /note="D->A: Abolishes shedding of CRIPTO."; /evidence="ECO:0000269|PubMed:27881714"; MUTAGEN 722; /note="H->A: Abolishes shedding of CRIPTO."; /evidence="ECO:0000269|PubMed:27881714"; MUTAGEN 726; /note="H->A: Abolishes shedding of CRIPTO."; /evidence="ECO:0000269|PubMed:27881714
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:11006113}.
uniprot
proteins
protein_family
TMEM8 family
uniprot
proteins
pubmed
11006113
uniprot
proteins
pubmed
11157797
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
21752829
uniprot
proteins
pubmed
26858401
uniprot
proteins
pubmed
27835684
uniprot
proteins
pubmed
27881714
uniprot
proteins
sequence_length
771
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27881714}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:21752829}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 546..566; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 569..589; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 606..626; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 630..650; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 654..674; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 691..711; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 718..738; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins