KLK6
entrez
5653
canonical
uniprot
Q92876
canonical
ensembl
ENSG00000167755
resolver
ensp
ENSP00000309148
resolver
ensp
ENSP00000366047
resolver
ensp
ENSP00000375684
resolver
genesymbol
KLK6
resolver
genesymbol_syn
PRSS18
resolver
genesymbol_syn
PRSS9
resolver
hgnc
HGNC:6367
resolver
uniprot
A6NJA1
resolver
uniprot
A8MW09
resolver
uniprot
Q6H301
resolver
uniprot_entry
KLK6_HUMAN
resolver
uniprot_sec
A6NJA1
resolver
uniprot_sec
A8MW09
resolver
uniprot_sec
Q6H301
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by a range of serine protease inhibitors including soybean trypsin inhibitor, benzamidine and serpins. Activated by a range of glycosaminoglycans including chondroitin sulfate, dermatan sulfate, heparan sulfate and heparin. {ECO:0000269|PubMed:12878203, ECO:0000269|PubMed:16321973}.
uniprot
proteins
amino_acid_sequence
MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLERDCSANTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTIQAK
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. {ECO:0000269|PubMed:11983703, ECO:0000269|PubMed:12878203, ECO:0000269|PubMed:12928483, ECO:0000269|PubMed:15557757, ECO:0000269|PubMed:16321973, ECO:0000269|PubMed:16987227}.
uniprot
proteins
mass_dalton
26856
uniprot
proteins
post_translational_modification
PTM: Inactivated by autolytic cleavage after Arg-80.
uniprot
proteins
protein_family
Kallikrein subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10610719
uniprot
proteins
pubmed
10997858
uniprot
proteins
pubmed
11018688
uniprot
proteins
pubmed
11054574
uniprot
proteins
pubmed
11668196
uniprot
proteins
pubmed
11983703
uniprot
proteins
pubmed
12016211
uniprot
proteins
pubmed
12878203
uniprot
proteins
pubmed
12928483
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15207701
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15557757
uniprot
proteins
pubmed
16321973
uniprot
proteins
pubmed
16800739
uniprot
proteins
pubmed
16987227
uniprot
proteins
pubmed
17417874
uniprot
proteins
pubmed
8898378
uniprot
proteins
pubmed
9003450
uniprot
proteins
pubmed
9312124
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.
uniprot
proteins