EIF3M
entrez
10480
canonical
uniprot
Q7L2H7
canonical
ensembl
ENSG00000149100
resolver
ensp
ENSP00000436049
resolver
ensp
ENSP00000436787
resolver
genesymbol
EIF3M
resolver
genesymbol_syn
HFLB5
resolver
genesymbol_syn
PCID1
resolver
hgnc
HGNC:24460
resolver
uniprot
A8K7X4
resolver
uniprot
B4E2Q4
resolver
uniprot
O60735
resolver
uniprot
Q2F836
resolver
uniprot
Q53HL6
resolver
uniprot
Q9BXW1
resolver
uniprot_entry
EIF3M_HUMAN
resolver
uniprot_sec
A8K7X4
resolver
uniprot_sec
B4E2Q4
resolver
uniprot_sec
O60735
resolver
uniprot_sec
Q2F836
resolver
uniprot_sec
Q53HL6
resolver
uniprot_sec
Q9BXW1
resolver
amino_acid_sequence
MSVPAFIDISEEDQAAELRAYLKSKGAEISEENSEGGLHVDLAQIIEACDVCLKEDDKDVESVMNSVVSLLLILEPDKQEALIESLCEKLVKFREGERPSLRLQLLSNLFHGMDKNTPVRYTVYCSLIKVAASCGAIQYIPTELDQVRKWISDWNLTTEKKHTLLRLLYEALVDCKKSDAASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFLEGELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDTLNAWKQNLNKVKNSLLSLSDT
uniprot
proteins
function
FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03012, ECO:0000269|PubMed:17403899, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2). {ECO:0000269|PubMed:15919898}.
uniprot
proteins
mass_dalton
42503
uniprot
proteins
mutagenesis
MUTAGEN 350; /note="L->P: Reduces HSV binding and entry."; /evidence="ECO:0000269|PubMed:15919899"; MUTAGEN 354; /note="L->P: Reduces HSV binding and entry."; /evidence="ECO:0000269|PubMed:15919899"; MUTAGEN 361; /note="L->P: Reduces HSV binding and entry."; /evidence="ECO:0000269|PubMed:15919899"; MUTAGEN 364; /note="V->P: Reduces HSV binding and entry."; /evidence="ECO:0000269|PubMed:15919899
uniprot
proteins
protein_family
EIF-3 subunit M family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15601822
uniprot
proteins
pubmed
15703437
uniprot
proteins
pubmed
15904532
uniprot
proteins
pubmed
15919898
uniprot
proteins
pubmed
15919899
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16766523
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17322308
uniprot
proteins
pubmed
17403899
uniprot
proteins
pubmed
17719568
uniprot
proteins
pubmed
18599441
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25849773
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27462815
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.
uniprot
proteins