Il3
entrez
16187
canonical
uniprot
P01586
canonical
ensembl
ENSMUSG00000018914
resolver
ensp
ENSMUSP00000019058
resolver
enst
ENSMUST00000019058
resolver
genesymbol
Il3
resolver
genesymbol_syn
Csfmu
resolver
genesymbol_syn
Il-3
resolver
uniprot
Q5SX77
resolver
uniprot_entry
IL3_MOUSE
resolver
uniprot_entry
Q5SX77_MOUSE
resolver
amino_acid_sequence
MVLASSTTSIHTMLLLLLMLFHLGLQASISGRDTHRLTRTLNCSSIVKEIIGKLPEPELKTDDEGPSLRNKSFRRVNLSKFVESQGEVDPEDRYVIKSNLQKLNCCLPTSANDSALPGVFIRDLDDFRKKLRFYMVHLNDLETVLTSRPPQPASGSVSPNRGTVEC
uniprot
proteins
function
FUNCTION: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Also stimulates mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (By similarity). Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (PubMed:10376805, PubMed:31990690, PubMed:8378315). Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (By similarity). {ECO:0000250|UniProtKB:P08700, ECO:0000269|PubMed:10376805, ECO:0000269|PubMed:31990690, ECO:0000269|PubMed:8378315, ECO:0000269|PubMed:9446636}.
uniprot
proteins
mass_dalton
18540
uniprot
proteins
protein_family
IL-3 family
uniprot
proteins
pubmed
10376805
uniprot
proteins
pubmed
1445902
uniprot
proteins
pubmed
21329364
uniprot
proteins
pubmed
31990690
uniprot
proteins
pubmed
3918308
uniprot
proteins
pubmed
3926497
uniprot
proteins
pubmed
3935516
uniprot
proteins
pubmed
6322187
uniprot
proteins
pubmed
6420702
uniprot
proteins
pubmed
8378315
uniprot
proteins
pubmed
9446636
uniprot
proteins
sequence_length
166
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins