Krt17
entrez
16667
canonical
uniprot
Q9QWL7
canonical
ensembl
ENSMUSG00000035557
resolver
ensp
ENSMUSP00000079699
resolver
enst
ENSMUST00000080893
resolver
genesymbol
Krt17
resolver
genesymbol_syn
Krt1-17
resolver
uniprot
A2A4G6
resolver
uniprot
Q61783
resolver
uniprot_entry
K1C17_MOUSE
resolver
uniprot_sec
A2A4G6
resolver
uniprot_sec
Q61783
resolver
amino_acid_sequence
MTTTIRQFTSSSSIKGSSGLGGGSSRTSCRLSGSLGAGSCRLGSASGLGSALGSNSYSSCYSFGTGSGYGGNFGGVDGLLAGGEKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQKQAPGPARDYSAYYHTIEDLKNKILVATVDNASILLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVGGEINVEMDAAPGVDLSRILSEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGSLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKPKEPVTTRQVRTIVEEVQDGKVISSREQVHQTTR
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in epithelial keratinocytes. Forms heteropolymers with type II keratins KRT6A and KRT6B, assembling into keratin filament networks that contribute to the structural integrity and specialized differentiation of various epithelial appendages, including nail bed and hair follicle (PubMed:14714564, PubMed:16702408, PubMed:9786956). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (PubMed:14714564, PubMed:16702408). Modulates the function of TNF in the specific context of hair cycling (PubMed:16702408). Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (PubMed:16710422). Involved in tissue repair (PubMed:20871598). Promotes epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (PubMed:20871598). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation (By similarity). {ECO:0000250|UniProtKB:Q04695, ECO:0000269|PubMed:14714564, ECO:0000269|PubMed:16702408, ECO:0000269|PubMed:16710422, ECO:0000269|PubMed:20871598, ECO:0000269|PubMed:9786956}.
uniprot
proteins
mass_dalton
48162
uniprot
proteins
mutagenesis
MUTAGEN 9; /note="T->A: Reduces binding to SNF."; /evidence="ECO:0000269|PubMed:16710422"; MUTAGEN 44; /note="S->A: Reduces binding to SNF."; /evidence="ECO:0000269|PubMed:16710422"; MUTAGEN 94; /note="R->P: Causes twisted hair shafts, broken hair follicles at sebaceous gland level and occasional rupture of the hair bulb or epidermal cyst-like changes."; /evidence="ECO:0000269|PubMed:14714564
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization. {ECO:0000250}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
10087197
uniprot
proteins
pubmed
10844551
uniprot
proteins
pubmed
11408584
uniprot
proteins
pubmed
12050118
uniprot
proteins
pubmed
14714564
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16702408
uniprot
proteins
pubmed
16710422
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20871598
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2433272
uniprot
proteins
pubmed
9786956
uniprot
proteins
sequence_length
433
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16702408, ECO:0000269|PubMed:16710422}.
uniprot
proteins