Mark3
entrez
170577
canonical
uniprot
Q8VHF0
canonical
ensembl
ENSRNOG00000010330
resolver
ensp
ENSRNOP00000014395
resolver
ensp
ENSRNOP00000068972
resolver
ensp
ENSRNOP00000073297
resolver
enst
ENSRNOT00000014395
resolver
enst
ENSRNOT00000080304
resolver
genesymbol
Mark3
resolver
uniprot
A0A0G2JU56
resolver
uniprot
F1M836
resolver
uniprot_entry
A0A0G2JU56_RAT
resolver
uniprot_entry
F1M836_RAT
resolver
uniprot_entry
MARK3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-211. Inhibited by phosphorylation on Thr-617 (By similarity). {ECO:0000250|UniProtKB:P27448}.
uniprot
proteins
amino_acid_sequence
MSTRTPLPTVNERDTENHISHGDGRQEVTSRTGRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKITDFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEEELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSAELDASDSSSSSNLSLAKVRPSSDLSNSTGQSPHHKGQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGVPSRKSGSSAVGGKGIAPASPMLGNASNPNKADIPERKKSPAVPSSNAASGGMTRRNTYVCSERCAADRHSVIQNGKESSLTEVFAYAASPASLCATSTCRLRHQRSMSVSASGHPKMVLPPIDSEGDTFKAITTPDQRTPVASTHSISSATTPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRLPTEYERNGRYEGSSRNVSSEQKDENREAKPRSLRFTWSMKTTSSMDPSDMMREIRKVLDANTCDYEQRERFLLFCVHGDGHAESLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1. {ECO:0000250|UniProtKB:P27448}.
uniprot
proteins
mass_dalton
88751
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-617 by PRKCZ/aPKC inhibits the kinase activity (By similarity). {ECO:0000250|UniProtKB:P27448}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SNF1 subfamily
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
797
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P27448}; Peripheral membrane protein {ECO:0000250|UniProtKB:P27448}. Cell projection, dendrite {ECO:0000250|UniProtKB:P27448}. Cytoplasm {ECO:0000250|UniProtKB:P27448}.
uniprot
proteins