TMT1B
entrez
196410
canonical
uniprot
Q6UX53
canonical
ensembl
ENSG00000170439
resolver
ensp
ENSP00000377796
resolver
enst
ENST00000394252
resolver
genesymbol
TMT1B
resolver
genesymbol_syn
METTL7B
resolver
hgnc
HGNC:28276
resolver
uniprot
A8K247
resolver
uniprot
Q8WUI1
resolver
uniprot_entry
TMT1B_HUMAN
resolver
uniprot_sec
A8K247
resolver
uniprot_sec
Q8WUI1
resolver
amino_acid_sequence
MDILVPLLQLLVLLLTLPLHLMALLGCWQPLCKSYFPYLMAVLTPKSNRKMESKKRELFSQIKGLTGASGKVALLELGCGTGANFQFYPPGCRVTCLDPNPHFEKFLTKSMAENRHLQYERFVVAPGEDMRQLADGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFFWEHVAEPYGSWAFMWQQVFEPTWKHIGDGCCLTRETWKDLENAQFSEIQMERQPPPLKWLPVGPHIMGKAVK
uniprot
proteins
ec_number
2.1.1.9
uniprot
proteins
function
FUNCTION: Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Selectively methylates S-centered nucleophiles from metabolites such as hydrogen sulfide and dithiothreitol. {ECO:0000269|PubMed:33649426, ECO:0000269|PubMed:37137720}.
uniprot
proteins
mass_dalton
27775
uniprot
proteins
mutagenesis
MUTAGEN 98; /note="D->A: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:33649426
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
33649426
uniprot
proteins
pubmed
37137720
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q562C4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q562C4}. Lipid droplet {ECO:0000250|UniProtKB:Q562C4}. Microsome {ECO:0000269|PubMed:37137720}. Cytoplasm, cytosol {ECO:0000269|PubMed:37137720}. Note=Highly concentrated in the perinuclear area of the endoplasmic reticulum (ER) and surrounding lipid droplets. May be associated with the specific regions of the LR that form lipid droplets and targeted to the initial deposits of lipids where the lipid droplets form. {ECO:0000250|UniProtKB:Q562C4}.
uniprot
proteins