Nipa1
entrez
233280
canonical
uniprot
Q8BHK1
canonical
ensembl
ENSMUSG00000047037
resolver
ensp
ENSMUSP00000053871
resolver
enst
ENSMUST00000052204
resolver
genesymbol
Nipa1
resolver
genesymbol_syn
Spg6
resolver
uniprot_entry
NIPA1_MOUSE
resolver
amino_acid_sequence
MGTAAAAAAAGEGARGPSPAAVSLGLGVAVVSSLVNGSTFVLQKKGIVRAKRRGTSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSILASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNPVFVGYLCIVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPSSQRALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKSNMKTD
uniprot
proteins
function
FUNCTION: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Zn(2+) and Co(2+) but to a much less extent than Mg(2+). {ECO:0000269|PubMed:17166836}.
uniprot
proteins
mass_dalton
34105
uniprot
proteins
mutagenesis
MUTAGEN 39; /note="T->R: Failure to correctly traffic to the cell membrane and diminished Mg(2+) transport."; /evidence="ECO:0000269|PubMed:17166836"; MUTAGEN 100; /note="G->R: Failure to correctly traffic to the cell membrane and complete loss of Mg(2+) transport."; /evidence="ECO:0000269|PubMed:17166836
uniprot
proteins
protein_family
NIPA family
uniprot
proteins
pubmed
14508708
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17166836
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17166836}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000269|PubMed:17166836}. Note=Recruited to the cell membrane in response to low extracellular magnesium.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 61..81; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 83..103; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 154..174; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 178..198; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 254..274; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 285..305; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins