Inhibition of host TBK1 by virus
uniprot_keyword
KW-1223
canonical
name
Inhibition of host TBK1 by virus
uniprot
definition
Viral protein involved in the evasion of host innate defenses by inhibiting the TBK1 kinase. Upon viral infection, Toll-like receptors (TLRs) or DNA recognition receptors recognize foreign material and transmit the signal to TBK1 that in turn phosphorylates and activates IRF3 and IRF7. Once phosphorylated, IRF3 and/or IRF7 translocate into the nucleus to drive transcription of interferons. Several viruses including herpes simplex virus 1 or vaccinia virus interact directly with and inhibit TBK1 to prevent IRFs activation.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
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uniprot
keywords