SMIM20
entrez
389203
canonical
uniprot
Q8N5G0
canonical
ensembl
ENSG00000250317
resolver
ensp
ENSP00000427407
resolver
ensp
ENSP00000429820
resolver
enst
ENST00000514384
resolver
genesymbol
SMIM20
resolver
genesymbol_syn
C4orf52
resolver
genesymbol_syn
MITRAC7
resolver
hgnc
HGNC:37260
resolver
uniprot
C9JYT8
resolver
uniprot
E5RH91
resolver
uniprot
Q9BRT5
resolver
uniprot_entry
E5RH91_HUMAN
resolver
uniprot_entry
SIM20_HUMAN
resolver
uniprot_sec
C9JYT8
resolver
uniprot_sec
Q9BRT5
resolver
amino_acid_sequence
MSRNLRTALIFGGFISLIGAAFYPIYFRPLMRLEEYKKEQAINRAGIVQEDVQPPGLKVWSDPFGRK
uniprot
proteins
function
FUNCTION: [Small integral membrane protein 20]: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (PubMed:26321642). Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C (PubMed:26321642). Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover (PubMed:26321642). {ECO:0000269|PubMed:26321642}.; FUNCTION: [Phoenixin-14]: Peptide involved in a broad spectrum of regulatory functions (By similarity). Is a ligand for GPR173 (By similarity). As part of the reproductive cycle, it regulates gonadotropin-releasing hormone (GnRH) signaling in the hypothalamus and pituitary gland which augments the release of luteinizing hormone (By similarity). Plays a protective role in memory retention through activation of GNRHR (By similarity). Regulates the secretion of AVP by hypothalamic neurons (By similarity). Plays a role in the transduction of the itch sensation (By similarity). Induces anxiolytic effects, reducing behavior associated with anxiety (By similarity). Regulates food intake as well as satiation and satiety (By similarity). In the ovary, it regulates follicular growth by stimulating granulosa cell proliferation by increasing the expression of GPR173, CREB1, CYP19A1, KITLG, FSHR, and LHCGR (PubMed:30933929). It also increases the production of estradiol (E2) (PubMed:30933929). In the heart, it regulates contractility and relaxation (By similarity). It also plays a cardioprotective role during ischemia, where it activates the SAFE and RISK pathways (By similarity). Stimulates the proliferation and differentiation of preadipocytes (By similarity). In pancreatic islet cells, it induces proliferation of islet cells as well as the production of INS (By similarity). {ECO:0000250|UniProtKB:C0HLM6, ECO:0000250|UniProtKB:D3Z7Q2, ECO:0000269|PubMed:30933929}.; FUNCTION: [Phoenixin-20]: Peptide involved in a broad spectrum of regulatory functions (By similarity). Is a ligand for GPR173 (By similarity). As part of the reproductive cycle, it regulates gonadotropin-releasing hormone (GnRH) signaling in the hypothalamus and pituitary gland which augments the release of luteinizing hormone (By similarity). Plays a protective role in memory retention through activation of GNRHR (By similarity). Regulates the secretion of AVP by hypothalamic neurons (By similarity). Plays a role in the transduction of the itch sensation (By similarity). Induces anxiolytic effects, reducing behavior associated with anxiety (By similarity). Regulates food intake as well as satiation and satiety (By similarity). In the ovary, it regulates follicular growth by stimulating granulosa cell proliferation by increasing the expression of GPR173, CREB1, CYP19A1, KITLG, FSHR, and LHCGR (PubMed:30933929). It also increases the production of estradiol (E2) (PubMed:30933929). In the heart, it regulates contractility and relaxation (By similarity). It also plays a cardioprotective role during ischemia, where it activates the SAFE and RISK pathways (By similarity). Stimulates the proliferation and differentiation of preadipocytes (By similarity). In pancreatic islet cells, it induces proliferation of islet cells as well as the production of INS (By similarity). {ECO:0000250|UniProtKB:C0HLM6, ECO:0000250|UniProtKB:D3Z7Q2, ECO:0000269|PubMed:30933929}.
uniprot
proteins
mass_dalton
7702
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
26321642
uniprot
proteins
pubmed
30933929
uniprot
proteins
sequence_length
67
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Small integral membrane protein 20]: Mitochondrion inner membrane {ECO:0000269|PubMed:26321642}; Single-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Phoenixin-14]: Secreted {ECO:0000250|UniProtKB:C0HLM6}.; SUBCELLULAR LOCATION: [Phoenixin-20]: Secreted {ECO:0000250|UniProtKB:C0HLM6}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins