SLC25A14
entrez
9016
canonical
uniprot
O95258
canonical
ensembl
ENSG00000102078
resolver
ensp
ENSP00000354455
resolver
ensp
ENSP00000444642
resolver
ensp
ENSP00000445225
resolver
ensp
ENSP00000477981
resolver
ensp
ENSP00000748572
resolver
ensp
ENSP00000771596
resolver
enst
ENST00000543953
resolver
genesymbol
SLC25A14
resolver
genesymbol_syn
BMCP1
resolver
genesymbol_syn
UCP5
resolver
hgnc
HGNC:10984
resolver
uniprot
B4DMK1
resolver
uniprot
D3DTG2
resolver
uniprot
F6SL11
resolver
uniprot
Q0VDH7
resolver
uniprot
Q9HC60
resolver
uniprot
Q9HC61
resolver
uniprot_entry
B4DMK1_HUMAN
resolver
uniprot_entry
F6SL11_HUMAN
resolver
uniprot_entry
UCP5_HUMAN
resolver
uniprot_sec
D3DTG2
resolver
uniprot_sec
Q0VDH7
resolver
uniprot_sec
Q9HC60
resolver
uniprot_sec
Q9HC61
resolver
activity_regulation
ACTIVITY REGULATION: Increased activity at pH lower than 8.0 (PubMed:31356773). sulfate/sulfate exchange activity is inhibited strongly by pyridoxal 5'-phosphate, bathophenanthroline and the organic mercurials mersalyl, p-chloromercuribenzoate and HgCl2 (PubMed:31356773). Proton conductance is activated by cardiolipin and long-chain free fatty acids and inhibited by purine nucleotides ATP and ADP. Chloride ion transporter activity is inhibited by long-chain free fatty acids. {ECO:0000269|PubMed:22524567, ECO:0000269|PubMed:26182433, ECO:0000269|PubMed:31356773}.
uniprot
proteins
amino_acid_sequence
MGIFPGIILIFLRVKFATAAVIVSGHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRLQI
uniprot
proteins
function
FUNCTION: Transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate and glutamate and tricarboxylates (PubMed:31356773). May catalyze the export of sulfite and thiosulfate (the hydrogen sulfide degradation products) from the mitochondria, thereby modulating the level of the hydrogen sulfide (Probable). Also can mediate a very low unidirectional transport of anions including sulfate, phosphate, (S)-malate, citrate, L-aspartate and L-glutamate (PubMed:31356773). Maintains oxidative balance (through uncoupling activities) and ATP production (by modifying mitochondrial membrane potential) (PubMed:20600837). Is able to transport protons across lipid membranes (PubMed:22524567, PubMed:26182433). Also exhibits transmembrane chloride transport activity to a lesser extent (PubMed:22524567, PubMed:26182433). May modify mitochondrial respiratory efficiency and mitochondrial oxidant production (By similarity). {ECO:0000250|UniProtKB:Q9Z2B2, ECO:0000269|PubMed:20600837, ECO:0000269|PubMed:22524567, ECO:0000269|PubMed:31356773, ECO:0000305|PubMed:31356773}.
uniprot
proteins
mass_dalton
36202
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
10928996
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
20600837
uniprot
proteins
pubmed
22524567
uniprot
proteins
pubmed
26182433
uniprot
proteins
pubmed
31356773
uniprot
proteins
pubmed
9852133
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:20600837}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..54; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 112..128; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 141..161; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 199..215; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 240..256; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 298..315; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins