Pias2
entrez
83422
canonical
uniprot
Q6AZ28
canonical
ensembl
ENSRNOG00000017493
resolver
ensp
ENSRNOP00000023886
resolver
ensp
ENSRNOP00000086650
resolver
ensp
ENSRNOP00000092581
resolver
ensp
ENSRNOP00000103276
resolver
ensp
ENSRNOP00000109402
resolver
enst
ENSRNOT00000107723
resolver
enst
ENSRNOT00000110007
resolver
enst
ENSRNOT00000129444
resolver
enst
ENSRNOT00000145398
resolver
genesymbol
Pias2
resolver
genesymbol_syn
Miz1
resolver
genesymbol_syn
Piasx
resolver
uniprot
A0A8I6A470
resolver
uniprot
A0A8I6GK87
resolver
uniprot
A0ABK0LF60
resolver
uniprot
A0ABK0LP71
resolver
uniprot
Q9Z177
resolver
uniprot_entry
A0A8I6A470_RAT
resolver
uniprot_entry
A0A8I6GK87_RAT
resolver
uniprot_entry
A0ABK0LF60_RAT
resolver
uniprot_entry
A0ABK0LP71_RAT
resolver
uniprot_entry
PIAS2_RAT
resolver
uniprot_sec
Q9Z177
resolver
amino_acid_sequence
MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCTPAVQIKIRELYRRRYPRTLEGLSDLSTIKSSVFSLDGSSSPVEPDLAVAGIHSLPSTSIAPHSPSSPVASVLLQDTKPTFEMQQPSPPIPPVHPDVQLKTLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVTSQPCTKVESSSVFSKPCSVTVASDASKKKIDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTPVSSMSSDLPGEQRRNDINNEVQLGTSSDTVQQ
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
function
FUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity (By similarity). Sumoylates PML at'Lys-65' and 'Lys-160' (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
63431
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="L->A: Loss of enhancement of AR and NR3C1-dependent transactivation; no effect on interaction with AR and NR3C1; when associated with A-305."; /evidence="ECO:0000269|PubMed:11893729"; MUTAGEN 304; /note="L->A: Loss of enhancement of AR and NR3C1-dependent transactivation; no effect on interaction with AR and NR3C1; when associated with A-23."; /evidence="ECO:0000269|PubMed:11893729"; MUTAGEN 324; /note="K->R: No effect on auto-sumoylation; when associated with R-326."; /evidence="ECO:0000269|PubMed:12077349"; MUTAGEN 326; /note="K->R: No effect on auto-sumoylation; when associated with R-324."; /evidence="ECO:0000269|PubMed:12077349"; MUTAGEN 379; /note="K->R: No effect on auto-sumoylation; when associated with R-380."; /evidence="ECO:0000269|PubMed:12077349"; MUTAGEN 380; /note="K->R: No effect on auto-sumoylation; when associated with R-379."; /evidence="ECO:0000269|PubMed:12077349"; MUTAGEN 383; /note="W->A: Loss of promotion of JUN sumoylation; no loss of interaction with SUMO1 and UBE2I."; /evidence="ECO:0000269|PubMed:12077349"; MUTAGEN 385; /note="C->S: Loss of NCOA2-binding; when associated with S-388."; /evidence="ECO:0000269|PubMed:11893729"; MUTAGEN 388; /note="C->S: Loss of NCOA2-binding; when associated with S-385."; /evidence="ECO:0000269|PubMed:11893729"; MUTAGEN 390; /note="K->R: No effect on auto-sumoylation; when associated with R-391."; /evidence="ECO:0000269|PubMed:12077349"; MUTAGEN 391; /note="K->R: No effect on auto-sumoylation; when associated with R-390."; /evidence="ECO:0000269|PubMed:12077349"; MUTAGEN 430; /note="K->R: No effect on auto-sumoylation; when associated with R-431."; /evidence="ECO:0000269|PubMed:12077349"; MUTAGEN 431; /note="K->R: No effect on auto-sumoylation; when associated with R-430."; /evidence="ECO:0000269|PubMed:12077349
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein sumoylation.
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000269|PubMed:12077349}.
uniprot
proteins
protein_family
PIAS family
uniprot
proteins
pubmed
11117529
uniprot
proteins
pubmed
11893729
uniprot
proteins
pubmed
12077349
uniprot
proteins
pubmed
12855578
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9920921
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:12077349, ECO:0000269|PubMed:9920921}. Nucleus, PML body {ECO:0000250|UniProtKB:O75928}. Nucleus {ECO:0000269|PubMed:9920921}. Note=Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (By similarity). Colocalizes with SUMO1 in nuclear granules (PubMed:12077349). {ECO:0000250|UniProtKB:O75928, ECO:0000269|PubMed:12077349}.
uniprot
proteins