SIGLEC8
entrez
27181
canonical
uniprot
Q9NYZ4
canonical
ensembl
ENSG00000105366
resolver
ensp
ENSP00000321077
resolver
ensp
ENSP00000339448
resolver
ensp
ENSP00000523088
resolver
genesymbol
SIGLEC8
resolver
genesymbol_syn
SAF2
resolver
hgnc
HGNC:10877
resolver
uniprot
Q7Z728
resolver
uniprot_entry
SIGL8_HUMAN
resolver
uniprot_sec
Q7Z728
resolver
amino_acid_sequence
MLLLLLLLPLLWGTKGMEGDRQYGDGYLLQVQELVTVQEGLCVHVPCSFSYPQDGWTDSDPVHGYWFRAGDRPYQDAPVATNNPDREVQAETQGRFQLLGDIWSNDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGTLESGHSRNLTCSVPWACKQGTPPMISWIGASVSSPGPTTARSSVLTLTPKPQDHGTSLTCQVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVCAVNSNPPARLSWTRGSLTLCPSRSSNPGLLELPRVHVRDEGEFTCRAQNAQGSQHISLSLSLQNEGTGTSRPVSQVTLAAVGGAGATALAFLSFCIIFIIVRSCRKKSARPAAGVGDTGMEDAKAIRGSASQGPLTESWKDGNPLKKPPPAVAPSSGEEGELHYATLSFHKVKPQDPQGQEATDSEYSEIKIHKRETAETQACLRNHNPSSKEVRG
uniprot
proteins
function
FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to blood cells (PubMed:10625619, PubMed:10856141). Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619). Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes (PubMed:27357658). {ECO:0000269|PubMed:10625619, ECO:0000269|PubMed:10856141, ECO:0000269|PubMed:27357658}.
uniprot
proteins
mass_dalton
54042
uniprot
proteins
mutagenesis
MUTAGEN 72; /note="R->A: Strongly impaired binding to 6'-sulfo sialyl-Lewis X."; /evidence="ECO:0000269|PubMed:27357658"; MUTAGEN 74; /note="Y->A: Modestly affected binding to 6'-sulfo sialyl-Lewis X."; /evidence="ECO:0000269|PubMed:27357658"; MUTAGEN 75; /note="Q->A: Modestly affected binding to 6'-sulfo sialyl-Lewis X."; /evidence="ECO:0000269|PubMed:27357658"; MUTAGEN 125; /note="R->A: Abolishes binding to 6'-sulfo sialyl-Lewis X."; /evidence="ECO:0000269|PubMed:27357658"; MUTAGEN 132; /note="K->A: Strongly impaired binding to 6'-sulfo sialyl-Lewis X."; /evidence="ECO:0000269|PubMed:27357658"; MUTAGEN 136; /note="K->A: Strongly impaired binding to 6'-sulfo sialyl-Lewis X."; /evidence="ECO:0000269|PubMed:27357658"; MUTAGEN 138; /note="Q->A: Minor effects on binding to 6'-sulfo sialyl-Lewis X."; /evidence="ECO:0000269|PubMed:27357658
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
SIGLEC (sialic acid binding Ig-like lectin) family
uniprot
proteins
pubmed
10625619
uniprot
proteins
pubmed
10856141
uniprot
proteins
pubmed
11095983
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
27357658
uniprot
proteins
sequence_length
499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 364..384; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins