Polr3c
entrez
310685
canonical
uniprot
Q5XIL3
canonical
ensembl
ENSRNOG00000033560
resolver
ensembl
ENSRNOG00055029413
resolver
ensembl
ENSRNOG00055032593
resolver
ensembl
ENSRNOG00060012753
resolver
ensembl
ENSRNOG00065032383
resolver
ensp
ENSRNOP00000028815
resolver
ensp
ENSRNOP00055041973
resolver
ensp
ENSRNOP00055046471
resolver
ensp
ENSRNOP00060017135
resolver
ensp
ENSRNOP00065045917
resolver
enst
ENSRNOT00000028815
resolver
enst
ENSRNOT00055050949
resolver
enst
ENSRNOT00055056356
resolver
enst
ENSRNOT00060021668
resolver
enst
ENSRNOT00065055751
resolver
genesymbol
Polr3c
resolver
uniprot
A0A8L2QFS6
resolver
uniprot_entry
A0A8L2QFS6_RAT
resolver
uniprot_entry
RPC3_RAT
resolver
amino_acid_sequence
MTQAEIKLCSLLLQEHFGEIVEKIGVHLIRTGSQPLRVIAHDTKASLDQVKKALCVLIHHNLVIYHVHKRGVVEYEAQCSRVLRMLRYPRYIYTTKTLYGDTGELIVEELLLNGKMTMSAVVKKVADRLTETMEDGKTMDYAEVSNAFVRLADTHFVQRCPLVPDTDSSDPGPPPPAPNLVINEKDMYLVPKLSLIGKGKRRRSSDEDAAGEPKAKKPRCTDNEEPTPDDGIYWQVNLDRFHQHFRDQAIVSAVANRMDQTSSEIVRTMLRMSEITTPSGAPFTQPLSSNEIFRSLPVGYNISKQVLDQYLTLLADDPLEFIGKAGDSGGGMYVINLHKALASLSTATLESVIQERFGSRCARIFRLVLQKKHLEQKQVEDFAMIPAKEAKDMLYKMLSENFISLQEIPKTPDHAPSRTFYLYTVNVLSAARMLLHRCYKSIANLIERRQFETKENKRLLEKSQRVEAIMASMQATGAEEVQLQEIEEMITAPERQQLETLKRNVNKLDASEIQVDETIFLLESYIESTMKRQ
uniprot
proteins
function
FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer, coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (By similarity). {ECO:0000250|UniProtKB:Q9BUI4}.
uniprot
proteins
mass_dalton
60543
uniprot
proteins
protein_family
Eukaryotic RPC3/POLR3C RNA polymerase subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
533
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BUI4}.
uniprot
proteins