Ppip5k2
entrez
227399
canonical
uniprot
Q6ZQB6
canonical
ensembl
ENSMUSG00000040648
resolver
ensp
ENSMUSP00000043401
resolver
ensp
ENSMUSP00000108466
resolver
ensp
ENSMUSP00000319686
resolver
ensp
ENSMUSP00000319687
resolver
ensp
ENSMUSP00000319689
resolver
ensp
ENSMUSP00000319692
resolver
ensp
ENSMUSP00000319693
resolver
ensp
ENSMUSP00000319695
resolver
ensp
ENSMUSP00000319696
resolver
ensp
ENSMUSP00000319697
resolver
ensp
ENSMUSP00000319698
resolver
ensp
ENSMUSP00000319700
resolver
ensp
ENSMUSP00000319701
resolver
ensp
ENSMUSP00000319707
resolver
ensp
ENSMUSP00000319714
resolver
ensp
ENSMUSP00000319722
resolver
ensp
ENSMUSP00000319724
resolver
ensp
ENSMUSP00000319725
resolver
genesymbol
Ppip5k2
resolver
genesymbol_syn
AW555814
resolver
genesymbol_syn
Hisppd1
resolver
genesymbol_syn
Kiaa0433
resolver
genesymbol_syn
Vip2
resolver
uniprot
E9PVE9
resolver
uniprot
Q3TM75
resolver
uniprot
Q3UUA3
resolver
uniprot
Q7TPU4
resolver
uniprot
Q8BWK5
resolver
uniprot_entry
Q8BWK5_MOUSE
resolver
uniprot_entry
VIP2_MOUSE
resolver
uniprot_sec
E9PVE9
resolver
uniprot_sec
Q3TM75
resolver
uniprot_sec
Q3UUA3
resolver
uniprot_sec
Q7TPU4
resolver
amino_acid_sequence
MSNSRKMSEPPRFFVGPEDAEINPGNYRRFFHHAEEEEEEEDESPPERQIVVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEEIILNEPVENWPLCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYLIQDRRDVYSILQAEGILLPRYAILNRDPNNPKECNLIEGEDHVEVNGEVFQKPFVEKPVSAEDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESNVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREKLIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKILGNIVMRELAPQFHIPWSIPLEAEDIPIVPTTSGTMMELRCVIAVIRHGDRTPKQKMKMEVRHQKFFDLFEKCDGYKSGKLKLKKPKQLQEVLDIARQLLMELGQNNDSEIEENKSKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDNRREEPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQQRVKARLHEILQKDRDFTAEDYEKLTPSGSISVIKSMHLIKNPVKTCDKVYSLIQSLTSQIRYRMEDPKSADIQLYHSETLELMLRRWSKLEKDFKTKNGRYDISKIPDIYDCIKYDVQHNGSLKLENTMELYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQRTQDDDTVNKLHPVYSRGVLSPERHVRTRLYFTSESHVHSLLSILRYGALCDDSKDEQWKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHFSPGAKGCEEDKNLPSGYGYRPASRENEGRRSLKTDDDEPHTSKRDEVDRAVMLFKPLVSEPIHIHRKSPLPRSRKITANEVVSENANYLRTPRNLVEQKQNPTVGFELYSMVPSICPLETLHNALFLKQVDDFLASIASPSTEVLRKVPEMSSMATRSSPGMRRKISLNTYTPTKILPTPPAALKSSKASSKAAAGGPSQAMAPHTSSRKKSINSKTEGHEPKKSTGKKR
uniprot
proteins
ec_number
2.7.4.24
uniprot
proteins
function
FUNCTION: Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:29590114}.
uniprot
proteins
mass_dalton
128427
uniprot
proteins
protein_family
Histidine acid phosphatase family
uniprot
proteins
protein_family
VIP1 subfamily
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17690096
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29590114
uniprot
proteins
sequence_length
1129
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O43314}.
uniprot
proteins