Egln2
entrez
112406
canonical
uniprot
Q91YE2
canonical
ensembl
ENSMUSG00000058709
resolver
ensp
ENSMUSP00000078966
resolver
ensp
ENSMUSP00000104019
resolver
ensp
ENSMUSP00000194588
resolver
ensp
ENSMUSP00000194589
resolver
ensp
ENSMUSP00000194608
resolver
enst
ENSMUST00000080058
resolver
enst
ENSMUST00000108382
resolver
genesymbol
Egln2
resolver
uniprot
Q80X29
resolver
uniprot
Q8C6I4
resolver
uniprot
Q8CIL9
resolver
uniprot
Q8VHJ1
resolver
uniprot
Q99MI0
resolver
uniprot_entry
EGLN2_MOUSE
resolver
uniprot_entry
Q80X29_MOUSE
resolver
uniprot_sec
Q8C6I4
resolver
uniprot_sec
Q8CIL9
resolver
uniprot_sec
Q8VHJ1
resolver
uniprot_sec
Q99MI0
resolver
amino_acid_sequence
MDSPCQPQALNQALPQLPGSVSESLESSRARMGVESYLPCPLLPAYHRPGASGEASAGNGTPRTTATATTTTASPLREGFGGQDGGELWPLQSEGAAALVTKECQRLAAQGARPEAPKRKWAKDGGDAPSPSKRPWARQENQEAKGESGMGCDSGASNSSSSSSNTTSSSGEASARLREEVQPSAPERLALDYIVPCMRYYGICVKDNFLGAVLGGRVLAEVEALKWGGRLRDGQLVSQRAIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGNYVINGRTKAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDAKERAAARDKYQLASGQKGVQVPVSQPTTPT
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
ec_number
1.14.11.29
uniprot
proteins
function
FUNCTION: Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:24809345). Target proteins are preferentially recognized via a LXXLAP motif (By similarity). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:18176562, PubMed:19587290, PubMed:21083501). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:18176562, PubMed:19587290, PubMed:21083501). Also hydroxylates HIF2A (PubMed:18176562, PubMed:19587290, PubMed:21083501). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:18176562, PubMed:19587290, PubMed:21083501). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:18176562, PubMed:19587290, PubMed:21083501). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:18176562, PubMed:19587290, PubMed:21083501). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:18176562, PubMed:19587290, PubMed:21083501). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:18176562, PubMed:19587290, PubMed:21083501). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (By similarity). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (By similarity). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (PubMed:24809345). {ECO:0000250|UniProtKB:Q96KS0, ECO:0000269|PubMed:18176562, ECO:0000269|PubMed:19587290, ECO:0000269|PubMed:21083501, ECO:0000269|PubMed:24809345}.
uniprot
proteins
mass_dalton
45109
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by SIAH1 and/or SIAH2 in response to the unfolded protein response (UPR), leading to its degradation. {ECO:0000269|PubMed:24809345}.
uniprot
proteins
pubmed
11574160
uniprot
proteins
pubmed
12234095
uniprot
proteins
pubmed
12360397
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18176562
uniprot
proteins
pubmed
19587290
uniprot
proteins
pubmed
21083501
uniprot
proteins
pubmed
24809345
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12360397}.
uniprot
proteins