P00176
uniprot
P00176
canonical
amino_acid_sequence
MEPTILLLLALLVGFLLLLVRGHPKSRGNFPPGPRPLPLLGNLLQLDRGGLLNSFMQLREKYGDVFTVHLGPRPVVMLCGTDTIKEALVGQAEDFSGRGTIAVIEPIFKEYGVIFANGERWKALRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKSQGAPLDPTFLFQCITANIICSIVFGERFDYTDRQFLRLLELFYRTFSLLSSFSSQVFEFFSGFLKYFPGAHRQISKNLQEILDYIGHIVEKHRATLDPSAPRDFIDTYLLRMEKEKSNHHTEFHHENLMISLLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLDDRSKMPYTDAVIHEIQRFSDLVPIGVPHRVTKDTMFRGYLLPKNTEVYPILSSALHDPQYFDHPDSFNPEHFLDANGALKKSEAFMPFSTGKRICLGEGIARNELFLFFTTILQNFSVSSHLAPKDIDLTPKESGIGKIPPTYQICFSAR
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
function
FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
uniprot
proteins
mass_dalton
55934
uniprot
proteins
mutagenesis
MUTAGEN 128; /note="S->A: Reduces interaction with HSP70; impairs interaction with HSP90."; /evidence="ECO:0000269|PubMed:19401463
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is accompanied by a decrease in enzyme activity. {ECO:0000269|PubMed:2583091}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
109438
uniprot
proteins
pubmed
19401463
uniprot
proteins
pubmed
2539047
uniprot
proteins
pubmed
2583091
uniprot
proteins
pubmed
2989270
uniprot
proteins
pubmed
6306654
uniprot
proteins
pubmed
6953431
uniprot
proteins
pubmed
8142377
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion inner membrane {ECO:0000305|PubMed:19401463}; Peripheral membrane protein {ECO:0000305|PubMed:19401463}. Note=Post-translationally targeted to mitochondria. Requires the cytosolic chaperones HSP70 and HSP90, for initial targeting to mitochondria, and then requires all three of the receptor proteins in the TOM complex, TOMM70, TOMM20 and TOMM22 for translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein. {ECO:0000305|PubMed:19401463}.
uniprot
proteins