MAS1
entrez
4142
canonical
uniprot
P04201
canonical
ensembl
ENSG00000130368
resolver
ensp
ENSP00000252660
resolver
ensp
ENSP00000501180
resolver
enst
ENST00000252660
resolver
enst
ENST00000674077
resolver
genesymbol
MAS1
resolver
genesymbol_syn
MAS
resolver
hgnc
HGNC:6899
resolver
uniprot
E1P5B3
resolver
uniprot
Q2TBC9
resolver
uniprot
Q6FG47
resolver
uniprot_entry
MAS_HUMAN
resolver
uniprot_sec
E1P5B3
resolver
uniprot_sec
Q2TBC9
resolver
uniprot_sec
Q6FG47
resolver
amino_acid_sequence
MDGSNVTSFVVEEPTNISTGRNASVGNAHRQIPIVHWVIMSISPVGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKYQSALVCALLWALSCLVTTMEYVMCIDREEESHSRNDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRLLYLLYYEYWSTFGNLHHISLLFSTINSSANPFIYFFVGSSKKKRFKESLKVVLTRAFKDEMQPRRQKDNCNTVTVETVV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that plays key roles in the renin-angiotensin system (RAS) specifically in the protective, counter-regulatory arm of the RAS (PubMed:25967876). Receptor mainly stimulated by angiotensin 1-7, which is a bioactive metabolite of the angiotensin produced by ACE2 (PubMed:17984366). Activation promotes nitric oxide via PI3K/Akt-eNOS pathway (PubMed:17984366). Modulates also the MAPK, ERK1/2, and NF-kappa-B signaling (PubMed:25967876). Positive regulation of AGTR1 levels occurs through activation of the G proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade (PubMed:15809376, PubMed:16611642). The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 (PubMed:15809376, PubMed:16611642). Acts as functional receptor for CXCL17 and induces chemotactic movement (PubMed:41167449). {ECO:0000250|UniProtKB:P30554, ECO:0000269|PubMed:15809376, ECO:0000269|PubMed:16611642, ECO:0000269|PubMed:17984366, ECO:0000269|PubMed:41167449}.
uniprot
proteins
mass_dalton
37465
uniprot
proteins
mutagenesis
MUTAGEN 138; /note="I->D: Fails to activate GNA11."; /evidence="ECO:0000269|PubMed:16611642
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15809376
uniprot
proteins
pubmed
16611642
uniprot
proteins
pubmed
17984366
uniprot
proteins
pubmed
25967876
uniprot
proteins
pubmed
26460884
uniprot
proteins
pubmed
3419518
uniprot
proteins
pubmed
3708691
uniprot
proteins
pubmed
41167449
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16611642}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..61; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 66..86; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 105..128; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 150..172; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 264..284; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins