KLKB1
entrez
3818
canonical
uniprot
P03952
canonical
ensembl
ENSG00000164344
resolver
ensp
ENSP00000264690
resolver
ensp
ENSP00000424469
resolver
ensp
ENSP00000530380
resolver
ensp
ENSP00000530381
resolver
ensp
ENSP00000645275
resolver
enst
ENST00000264690
resolver
enst
ENST00000513864
resolver
enst
ENST00000860321
resolver
genesymbol
KLKB1
resolver
genesymbol_syn
KLK3
resolver
hgnc
HGNC:6371
resolver
uniprot
A6NH96
resolver
uniprot
A8K9A9
resolver
uniprot
B2R8H9
resolver
uniprot
B4DMX2
resolver
uniprot
E9PBC5
resolver
uniprot
Q17RE8
resolver
uniprot
Q17RE9
resolver
uniprot
Q4W5C3
resolver
uniprot_entry
A8K9A9_HUMAN
resolver
uniprot_entry
B4DMX2_HUMAN
resolver
uniprot_entry
E9PBC5_HUMAN
resolver
uniprot_entry
KLKB1_HUMAN
resolver
uniprot_sec
A6NH96
resolver
uniprot_sec
B2R8H9
resolver
uniprot_sec
Q17RE8
resolver
uniprot_sec
Q17RE9
resolver
uniprot_sec
Q4W5C3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by SERPINA5. {ECO:0000269|PubMed:2844223}.
uniprot
proteins
amino_acid_sequence
MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLFSFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVDMRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIKVLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFFTFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGVDFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRIAYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
uniprot
proteins
disease_involvement
DISEASE: Prekallikrein deficiency (PKKD) [MIM:612423]: An autosomal recessive condition characterized by a clotting defect due to prolongation of activated partial thromboplastin time. Affected individuals are clinically asymptomatic. {ECO:0000269|PubMed:14652634, ECO:0000269|PubMed:17598838, ECO:0000269|PubMed:34847617}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.21.34
uniprot
proteins
function
FUNCTION: Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
uniprot
proteins
mass_dalton
71343
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
protein_family
Plasma kallikrein subfamily
uniprot
proteins
pubmed
11031105
uniprot
proteins
pubmed
12754519
uniprot
proteins
pubmed
14652634
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
17598838
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
1998666
uniprot
proteins
pubmed
2844223
uniprot
proteins
pubmed
33732248
uniprot
proteins
pubmed
34847617
uniprot
proteins
pubmed
3521732
uniprot
proteins
pubmed
36756125
uniprot
proteins
sequence_length
638
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins