FCN1
entrez
2219
canonical
uniprot
O00602
canonical
ensembl
ENSG00000085265
resolver
ensp
ENSP00000360871
resolver
enst
ENST00000371806
resolver
genesymbol
FCN1
resolver
genesymbol_syn
FCNM
resolver
hgnc
HGNC:3623
resolver
uniprot
Q5VYV5
resolver
uniprot
Q92596
resolver
uniprot_entry
FCN1_HUMAN
resolver
uniprot_sec
Q5VYV5
resolver
uniprot_sec
Q92596
resolver
amino_acid_sequence
MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA
uniprot
proteins
function
FUNCTION: Extracellular lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:16116205, PubMed:17897951, PubMed:20032467). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:16116205, PubMed:20032467). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (PubMed:20032467, PubMed:20400674). May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). {ECO:0000269|PubMed:16116205, ECO:0000269|PubMed:17897951, ECO:0000269|PubMed:20032467, ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}.
uniprot
proteins
mass_dalton
35078
uniprot
proteins
mutagenesis
MUTAGEN 250; /note="G->F: Inhibits binding to the 9-O-acetylated sialic acid derivatives."; /evidence="ECO:0000269|PubMed:20032467"; MUTAGEN 285; /note="A->V: Inhibits binding to the 9-O-acetylated sialic acid derivatives."; /evidence="ECO:0000269|PubMed:20032467"; MUTAGEN 300; /note="Y->F: Abolishes interaction with all sialic acid-containing glycans."; /evidence="ECO:0000269|PubMed:20032467
uniprot
proteins
protein_family
Ficolin lectin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16116205
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17148457
uniprot
proteins
pubmed
17897951
uniprot
proteins
pubmed
20032467
uniprot
proteins
pubmed
20400674
uniprot
proteins
pubmed
21037097
uniprot
proteins
pubmed
8573080
uniprot
proteins
pubmed
8947836
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}. Cell surface {ECO:0000269|PubMed:16116205, ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}. Note=Specifically binds carbohydrates on the surface of pathogens (PubMed:16116205). Found on the monocyte and granulocyte surface (PubMed:20400674). {ECO:0000269|PubMed:16116205, ECO:0000269|PubMed:20400674}.
uniprot
proteins