S100A1
entrez
6271
canonical
uniprot
P23297
canonical
ensembl
ENSG00000160678
resolver
ensp
ENSP00000292169
resolver
ensp
ENSP00000553622
resolver
ensp
ENSP00000553623
resolver
enst
ENST00000292169
resolver
enst
ENST00000883563
resolver
enst
ENST00000883564
resolver
genesymbol
S100A1
resolver
genesymbol_syn
S100A
resolver
hgnc
HGNC:10486
resolver
uniprot
A0A0S2Z4H2
resolver
uniprot
B2R5D9
resolver
uniprot
Q5T7Y3
resolver
uniprot_entry
A0A0S2Z4H2_HUMAN
resolver
uniprot_entry
S10A1_HUMAN
resolver
uniprot_sec
B2R5D9
resolver
uniprot_sec
Q5T7Y3
resolver
amino_acid_sequence
MGSELETAMETLINVFHAHSGKEGDKYKLSKKELKELLQTELSGFLDAQKDVDAVDKVMKELDENGDGEVDFQEYVVLVAALTVACNNFFWENS
uniprot
proteins
function
FUNCTION: Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (PubMed:23351007). These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290). Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446). {ECO:0000269|PubMed:11717446, ECO:0000269|PubMed:12804600, ECO:0000269|PubMed:22399290, ECO:0000269|PubMed:23351007}.
uniprot
proteins
mass_dalton
10546
uniprot
proteins
post_translational_modification
PTM: Glutathionylated; glutathionylation increases affinity to calcium about 10-fold. {ECO:0000269|PubMed:15885104}.
uniprot
proteins
protein_family
S-100 family
uniprot
proteins
pubmed
11717446
uniprot
proteins
pubmed
12042313
uniprot
proteins
pubmed
12804600
uniprot
proteins
pubmed
1384693
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15171681
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15885104
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18650434
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
20188096
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21296671
uniprot
proteins
pubmed
22399290
uniprot
proteins
pubmed
22989881
uniprot
proteins
pubmed
23351007
uniprot
proteins
pubmed
28368280
uniprot
proteins
sequence_length
94
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15171681}. Sarcoplasmic reticulum {ECO:0000269|PubMed:12804600}. Mitochondrion {ECO:0000250|UniProtKB:P56565}.
uniprot
proteins