Cox6c2
entrez
54322
canonical
uniprot
P11951
canonical
ensembl
ENSRNOG00000010807
resolver
ensembl
ENSRNOG00055028039
resolver
ensembl
ENSRNOG00060009824
resolver
ensembl
ENSRNOG00065002189
resolver
ensp
ENSRNOP00000014407
resolver
ensp
ENSRNOP00055039880
resolver
ensp
ENSRNOP00060012950
resolver
ensp
ENSRNOP00065001991
resolver
enst
ENSRNOT00000014407
resolver
enst
ENSRNOT00055048514
resolver
enst
ENSRNOT00060016581
resolver
enst
ENSRNOT00065002884
resolver
genesymbol
Cox6c2
resolver
genesymbol_syn
Cox6c
resolver
uniprot
Q63703
resolver
uniprot_entry
CX6C2_RAT
resolver
uniprot_sec
Q63703
resolver
amino_acid_sequence
MSSGALLPKPQMRGLLAKRLRVHIVGAFVVALGVAAAYKFGVAEPRKKAYADFYRNYDSMKDFEEMRQAGVFQSAK
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P04038}.
uniprot
proteins
mass_dalton
8455
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P04038}.
uniprot
proteins
protein_family
Cytochrome c oxidase subunit 6c family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2822403
uniprot
proteins
pubmed
2836143
uniprot
proteins
pubmed
2854406
uniprot
proteins
pubmed
6200111
uniprot
proteins
pubmed
7601105
uniprot
proteins
sequence_length
76
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P04038}; Single-pass membrane protein {ECO:0000250|UniProtKB:P04038}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..55; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P04038
uniprot
proteins