OSBPL3
entrez
26031
canonical
uniprot
Q9H4L5
canonical
ensembl
ENSG00000070882
resolver
ensp
ENSP00000315410
resolver
ensp
ENSP00000379706
resolver
ensp
ENSP00000379708
resolver
ensp
ENSP00000386953
resolver
ensp
ENSP00000610482
resolver
ensp
ENSP00000610483
resolver
genesymbol
OSBPL3
resolver
genesymbol_syn
KIAA0704
resolver
genesymbol_syn
ORP3
resolver
genesymbol_syn
OSBP3
resolver
hgnc
HGNC:16370
resolver
uniprot
A4D167
resolver
uniprot
A4D168
resolver
uniprot
A4D169
resolver
uniprot
A4D170
resolver
uniprot
A4D171
resolver
uniprot
A4D172
resolver
uniprot
B8ZZ79
resolver
uniprot
B8ZZP0
resolver
uniprot
O14591
resolver
uniprot
O43357
resolver
uniprot
O43358
resolver
uniprot
Q8N702
resolver
uniprot
Q8N703
resolver
uniprot
Q8N704
resolver
uniprot
Q8NFH0
resolver
uniprot
Q8NFH1
resolver
uniprot
Q8NI12
resolver
uniprot
Q8NI13
resolver
uniprot
Q9BZF4
resolver
uniprot
Q9UED6
resolver
uniprot_entry
OSBL3_HUMAN
resolver
uniprot_sec
A4D167
resolver
uniprot_sec
A4D168
resolver
uniprot_sec
A4D169
resolver
uniprot_sec
A4D170
resolver
uniprot_sec
A4D171
resolver
uniprot_sec
A4D172
resolver
uniprot_sec
B8ZZ79
resolver
uniprot_sec
B8ZZP0
resolver
uniprot_sec
O14591
resolver
uniprot_sec
O43357
resolver
uniprot_sec
O43358
resolver
uniprot_sec
Q8N702
resolver
uniprot_sec
Q8N703
resolver
uniprot_sec
Q8N704
resolver
uniprot_sec
Q8NFH0
resolver
uniprot_sec
Q8NFH1
resolver
uniprot_sec
Q8NI12
resolver
uniprot_sec
Q8NI13
resolver
uniprot_sec
Q9BZF4
resolver
uniprot_sec
Q9UED6
resolver
amino_acid_sequence
MMSDEKNLGVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGEMNYTQEPPVQKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKSEEVFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFSGSTITDSSSGVFDSISSRKRSSISKQNLFQTGSNVSFSCGGETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLLQSMDVLHRTYSAPAINAIQGGSFESPKKEKRSHRRWRSRAIGKDAKGTLQVPKPFSGPVRLHSSNPNLSTLDFGEEKNYSDGSETSSEFSKMQEDLCHIAHKVYFTLRSAFNIMSAEREKLKQLMEQDASSSPSAQVIGLKNALSSALAQNTDLKERLRRIHAESLLLDSPAVAKSGDNLAEENSRDENRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSYVSDISDNLSLDNLSNDLDNERQTLGPVLDSGREAKSRRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLERMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPISACHAESRNFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESIYCGGGSSSACVWRANPMPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERRRVLEENHVEHQPRFFRKSDDDSWVSNGTYLELRKDLGFSKLDHPVLW
uniprot
proteins
function
FUNCTION: Lipid transfer protein that mediates the non-vesicular transport of phosphoinositide 4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), or PI(4)P) at the plasma membrane (PM)/ endoplasmic reticulum (ER) contact sites (PubMed:16143324, PubMed:32041906, PubMed:32234213). Extracts PI4P from the PM, in exchange for phosphatidylcholine (PubMed:32234213). Can bind to the ER membrane protein VAPA and recruit VAPA to PM sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204, ECO:0000269|PubMed:32041906, ECO:0000269|PubMed:32234213}.
uniprot
proteins
mass_dalton
101224
uniprot
proteins
mutagenesis
MUTAGEN 60; /note="K->I: Abolishes plasma membrane targeting and nuclear localization."; /evidence="ECO:0000269|PubMed:16143324"; MUTAGEN 61; /note="K->A: Abolishes plasma membrane targeting and nuclear localization."; /evidence="ECO:0000269|PubMed:16143324"; MUTAGEN 71; /note="K->A: Abolishes plasma membrane targeting and nuclear localization."; /evidence="ECO:0000269|PubMed:16143324"; MUTAGEN 72; /note="R->I: Abolishes plasma membrane targeting and nuclear localization."; /evidence="ECO:0000269|PubMed:16143324"; MUTAGEN 97; /note="G->E: Decreases plasma membrane targeting and nuclear localization."; /evidence="ECO:0000269|PubMed:16143324"; MUTAGEN 162..167; /note="FFSGST->AAAAAA: No effect on interaction with VAPA."; /evidence="ECO:0000269|PubMed:25447204"; MUTAGEN 451..453; /note="FFD->VVV: Reduces VAPA binding. Abolishes association with endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:25447204
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is enhanced in vitro by phorbol-12-myristate-13-acetate (PMA), forskolin and calcium ionophore A23187 (PubMed:25447204). Phosphorylation seems to be stimulated in conditions of low cell-cell (or cell-matrix) adhesion (PubMed:18270267). {ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}.
uniprot
proteins
protein_family
OSBP family
uniprot
proteins
pubmed
11483621
uniprot
proteins
pubmed
11568019
uniprot
proteins
pubmed
11735225
uniprot
proteins
pubmed
12590732
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14593528
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16143324
uniprot
proteins
pubmed
17428193
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18270267
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25447204
uniprot
proteins
pubmed
32041906
uniprot
proteins
pubmed
32234213
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
887
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16143324}; Peripheral membrane protein {ECO:0000269|PubMed:16143324}. Cytoplasm, cytosol {ECO:0000269|PubMed:16143324}. Cell membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}; Peripheral membrane protein {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. Cell projection, filopodium tip {ECO:0000269|PubMed:18270267}. Nucleus membrane {ECO:0000269|PubMed:16143324}; Peripheral membrane protein {ECO:0000305}. Note=Co-localizes with OSBPL6 at contact sites between the plasma membrane and the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q9DBS9}.
uniprot
proteins