SRSF6
entrez
6431
canonical
uniprot
Q13247
canonical
ensembl
ENSG00000124193
resolver
ensp
ENSP00000244020
resolver
ensp
ENSP00000713423
resolver
genesymbol
SRSF6
resolver
genesymbol_syn
SFRS6
resolver
genesymbol_syn
SRP55
resolver
hgnc
HGNC:10788
resolver
uniprot
B7Z6J3
resolver
uniprot
E1P5W6
resolver
uniprot
Q13244
resolver
uniprot
Q13245
resolver
uniprot
Q96J06
resolver
uniprot
Q9UJB8
resolver
uniprot
Q9Y3N7
resolver
uniprot_entry
SRSF6_HUMAN
resolver
uniprot_sec
B7Z6J3
resolver
uniprot_sec
E1P5W6
resolver
uniprot_sec
Q13244
resolver
uniprot_sec
Q13245
resolver
uniprot_sec
Q96J06
resolver
uniprot_sec
Q9UJB8
resolver
uniprot_sec
Q9Y3N7
resolver
amino_acid_sequence
MPRVYIGRLSYNVREKDIQRFFSGYGRLLEVDLKNGYGFVEFEDSRDADDAVYELNGKELCGERVIVEHARGPRRDRDGYSYGSRSGGGGYSSRRTSGRDKYGPPVRTEYRLIVENLSSRCSWQDLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTEINGRNIRLIEDKPRTSHRRSYSGSRSRSRSRRRSRSRSRRSSRSRSRSISKSRSRSRSRSKGRSRSRSKGRKSRSKSKSKPKSDRGSHSHSRSRSKDEYEKSRSRSRSRSPKENGKGDIKSKSRSRSQSRSNSPLPVPPSKARSVSPPPKRATSRSRSRSRSKSRSRSRSSSRD
uniprot
proteins
function
FUNCTION: Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:22767602, ECO:0000269|PubMed:24440982}.
uniprot
proteins
mass_dalton
39587
uniprot
proteins
mutagenesis
MUTAGEN 280; /note="S->A: No effect on regulation of alternative splicing of MAPT/Tau exon 10 by DYRK1A."; /evidence="ECO:0000269|PubMed:22767602"; MUTAGEN 303; /note="S->A: Abolishes regulatory effect of DYRK1A on alternative splicing of MAPT/Tau exon 10."; /evidence="ECO:0000269|PubMed:22767602"; MUTAGEN 316; /note="S->A: No effect on regulation of alternative splicing of MAPT/Tau exon 10 by DYRK1A."; /evidence="ECO:0000269|PubMed:22767602
uniprot
proteins
post_translational_modification
PTM: Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by DYRK1A, probably in the RS domain. Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10. {ECO:0000269|PubMed:22767602}.
uniprot
proteins
protein_family
Splicing factor SR family
uniprot
proteins
pubmed
10757789
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12549914
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15009664
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1577277
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22767602
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24440982
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
7556075
uniprot
proteins
sequence_length
344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:22767602}. Nucleus speckle {ECO:0000269|PubMed:22767602}.
uniprot
proteins