Foxe3
entrez
30923
canonical
uniprot
Q9QY14
canonical
ensembl
ENSMUSG00000044518
resolver
ensp
ENSMUSP00000050445
resolver
enst
ENSMUST00000050940
resolver
genesymbol
Foxe3
resolver
uniprot_entry
FOXE3_MOUSE
resolver
amino_acid_sequence
MDAQVAFSGFPALPSLTPSGPQLPTLAGAEPGREPEEVVGGGDAEPTAVPGPGKRRRRPLQRGKPPYSYIALIAMALAHAPGRRLTLAAIYRFITERFAFYRDSPRKWQNSIRHNLTLNDCFVKVPREPGNPGKGNYWTLDPAAADMFDNGSFLRRRKRFKRAELPAPPPPPPPFPYAPFPPPPAPASAPPARLFRLDSLLGLQPEPPGPVAPEPPCCAAPDAAFPPCAAAASPPLYSPASERLGLPAPLPAQPLLALAGSAGALGPLGAGEAYLRQPGFAPGLERYL
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Foxe3 are the cause of the dysgenetic lens (dyl) phenotype. In mouse mutant dyl the lens vesicle fails to separate from the ectoderm, causing a fusion between the lens and the cornea. Lack of a proliferating anterior lens epithelium leads to absence of secondary lens fibers and a dysplastic, cataractous lens. {ECO:0000269|PubMed:10652278, ECO:0000269|PubMed:10890982}.
uniprot
proteins
function
FUNCTION: Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:10652278, PubMed:10890982). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (PubMed:16199865). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (PubMed:10652278). Is required for morphogenesis and differentiation of the anterior segment of the eye (PubMed:17064680). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (By similarity). {ECO:0000250|UniProtKB:Q13461, ECO:0000269|PubMed:10652278, ECO:0000269|PubMed:10890982, ECO:0000269|PubMed:16199865, ECO:0000269|PubMed:17064680}.
uniprot
proteins
mass_dalton
30541
uniprot
proteins
pubmed
10652278
uniprot
proteins
pubmed
10890982
uniprot
proteins
pubmed
11980846
uniprot
proteins
pubmed
16199865
uniprot
proteins
pubmed
17064680
uniprot
proteins
pubmed
26854927
uniprot
proteins
pubmed
27218149
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17064680}.
uniprot
proteins