Rab9
entrez
56382
canonical
uniprot
Q9R0M6
canonical
ensembl
ENSMUSG00000079316
resolver
ensp
ENSMUSP00000123325
resolver
ensp
ENSMUSP00000184673
resolver
ensp
ENSMUSP00000184686
resolver
ensp
ENSMUSP00000332584
resolver
enst
ENSMUST00000112091
resolver
genesymbol
Rab9
resolver
genesymbol
Rab9a
resolver
genesymbol_syn
Rab9
resolver
genesymbol_syn
Rab9A
resolver
genesymbol_syn
Sid99
resolver
uniprot
Q0PD48
resolver
uniprot_entry
Q0PD48_MOUSE
resolver
uniprot_entry
RAB9A_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:P51151}.
uniprot
proteins
amino_acid_sequence
MAGKSSLFKIILLGDGGVGKSSLMNRYVTNKFDSQLFHTIGVEFLNKDLEVDGHFVTMQIWDTAGQERFRSLRTPFYRGSDCCLLTFSVDDSQSFQNLSNWKKEFIYYADVKEPESFPFVILGNKTDIKERQVSTEEAQAWCKDNGDYPYFETSAKDSTNVAAAFEEAVRRILATEDRSEHLIQTDTVNLHRKPKPNSSCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB9A is involved in the transport of proteins between the endosomes and the trans-Golgi network (TGN). Specifically uses NDE1/NDEL1 as an effector to interact with the dynein motor complex in order to control retrograde trafficking of RAB9-associated late endosomes to the TGN (By similarity). Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (PubMed:26620560). {ECO:0000250|UniProtKB:P51151, ECO:0000250|UniProtKB:P62820, ECO:0000269|PubMed:26620560}.
uniprot
proteins
mass_dalton
22910
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20048159
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25220469
uniprot
proteins
pubmed
26620560
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P51151}; Lipid-anchor {ECO:0000250|UniProtKB:P51151}; Cytoplasmic side {ECO:0000250|UniProtKB:P51151}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P51151}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P51151}. Late endosome {ECO:0000250|UniProtKB:P51151}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:P51151}; Lipid-anchor {ECO:0000250|UniProtKB:P51151}; Cytoplasmic side {ECO:0000250|UniProtKB:P51151}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P51151}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P51151}. Melanosome {ECO:0000269|PubMed:26620560}. Note=Colocalizes with OSBPL1A at the late endosome. Recruited to phagosomes containing S.aureus or M.tuberculosis. Mainly localizes to late endosomes and partially localizes to Golgi. Colocalizes with NDE1 to membrane vesicles. {ECO:0000250|UniProtKB:P51151}.
uniprot
proteins