Fzd4
entrez
64558
canonical
uniprot
Q9QZH0
canonical
ensembl
ENSRNOG00000063590
resolver
ensembl
ENSRNOG00055019371
resolver
ensembl
ENSRNOG00060021248
resolver
ensembl
ENSRNOG00065028846
resolver
ensp
ENSRNOP00000088712
resolver
ensp
ENSRNOP00055026776
resolver
ensp
ENSRNOP00060030306
resolver
ensp
ENSRNOP00065040867
resolver
enst
ENSRNOT00000106139
resolver
enst
ENSRNOT00055033049
resolver
enst
ENSRNOT00060036795
resolver
enst
ENSRNOT00065049779
resolver
genesymbol
Fzd4
resolver
uniprot_entry
FZD4_RAT
resolver
amino_acid_sequence
MAWQGTGPSVRGMPGGVRLRLGLLLLQLLLLQRPALGFGDEEERRCDPIRIAMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPDSLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTTFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQSLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGNETVV
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins (By similarity). Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (By similarity). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase (By similarity). Both pathways seem to involve interactions with G proteins (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (By similarity). {ECO:0000250|UniProtKB:Q61088, ECO:0000250|UniProtKB:Q9ULV1}.
uniprot
proteins
mass_dalton
60355
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9ULV1}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 214..244; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9ULV1"; TRANSMEM 251..276; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9ULV1"; TRANSMEM 301..334; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9ULV1"; TRANSMEM 338..366; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9ULV1"; TRANSMEM 385..419; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9ULV1"; TRANSMEM 433..461; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9ULV1"; TRANSMEM 475..496; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9ULV1
uniprot
proteins