KEL
entrez
3792
canonical
uniprot
P23276
canonical
ensembl
ENSG00000197993
resolver
ensembl
ENSG00000276615
resolver
ensp
ENSP00000347409
resolver
ensp
ENSP00000477793
resolver
ensp
ENSP00000619912
resolver
enst
ENST00000355265
resolver
enst
ENST00000615381
resolver
genesymbol
KEL
resolver
hgnc
HGNC:6308
resolver
uniprot
B2RBV4
resolver
uniprot
Q96RS8
resolver
uniprot
Q99885
resolver
uniprot_entry
KELL_HUMAN
resolver
uniprot_sec
B2RBV4
resolver
uniprot_sec
Q96RS8
resolver
uniprot_sec
Q99885
resolver
amino_acid_sequence
MEGGDQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWAVARRVLTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW
uniprot
proteins
ec_number
3.4.24.-
uniprot
proteins
function
FUNCTION: Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. {ECO:0000269|PubMed:10438732}.
uniprot
proteins
mass_dalton
82824
uniprot
proteins
mutagenesis
MUTAGEN 72; /note="C->S: Loss of Kell-XK complex."; /evidence="ECO:0000269|PubMed:9593744"; MUTAGEN 319; /note="C->S: No loss of Kell-XK complex."; /evidence="ECO:0000269|PubMed:9593744"; MUTAGEN 582; /note="E->G: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:10438732
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:11336649}.
uniprot
proteins
protein_family
Peptidase M13 family
uniprot
proteins
pubmed
10438732
uniprot
proteins
pubmed
10891471
uniprot
proteins
pubmed
11336649
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1712490
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
7570911
uniprot
proteins
pubmed
7849312
uniprot
proteins
pubmed
7858266
uniprot
proteins
pubmed
8669078
uniprot
proteins
pubmed
9354821
uniprot
proteins
pubmed
9593744
uniprot
proteins
sequence_length
732
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Note=Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.
uniprot
proteins
transmembrane_region
TRANSMEM 48..67; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins