Tssk2
entrez
22115
canonical
uniprot
O54863
canonical
ensembl
ENSMUSG00000045521
resolver
ensp
ENSMUSP00000051035
resolver
enst
ENSMUST00000055374
resolver
genesymbol
Tssk2
resolver
genesymbol_syn
Stk22b
resolver
uniprot
Q6P8M9
resolver
uniprot_entry
TSSK2_MOUSE
resolver
uniprot_sec
Q6P8M9
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-174, potentially by autophosphorylation. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MDDAAVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHRSIIKTYEIFETSDGRIYIVMELGVQGDLLEFIKCRGALHEDVARKMFRQLSSAVKYCHDLDVVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDGSGRIVLSKTFCGSAAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIKKMLRIQKEHRVDFPRSKNLTGECKDLIYRILQPDVNRRLHIDEILSHSWLQPPKPKAMSSASFKREGEGKYRADCKLDTRPGSRPEHRPDHKLATKPQQRMLVTPENEDRMEDRLAETSRAKDHHISGAEVEKAST
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-281' of TSKS and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. {ECO:0000269|PubMed:18367677, ECO:0000269|PubMed:18533145, ECO:0000269|PubMed:20053632, ECO:0000269|PubMed:9412477}.
uniprot
proteins
mass_dalton
41022
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000250|UniProtKB:Q96PF2}.; PTM: Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation. {ECO:0000269|PubMed:23599433}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10781952
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18367677
uniprot
proteins
pubmed
18495105
uniprot
proteins
pubmed
18533145
uniprot
proteins
pubmed
20053632
uniprot
proteins
pubmed
20729278
uniprot
proteins
pubmed
23599433
uniprot
proteins
pubmed
9412477
uniprot
proteins
pubmed
9651519
uniprot
proteins
sequence_length
358
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compartment. In spermatids, concentrates in centrioles during flagellogenesis. Localizes in the tail and acrosomal regions of epididymal sperm.
uniprot
proteins