CYP27C1
entrez
339761
canonical
uniprot
Q4G0S4
canonical
ensembl
ENSG00000186684
resolver
ensp
ENSP00000334128
resolver
ensp
ENSP00000387198
resolver
ensp
ENSP00000499243
resolver
enst
ENST00000664447
resolver
genesymbol
CYP27C1
resolver
hgnc
HGNC:33480
resolver
uniprot
A0A590UJ17
resolver
uniprot
A0A7N4I3A3
resolver
uniprot
Q6ZNI7
resolver
uniprot_entry
A0A7N4I3A3_HUMAN
resolver
uniprot_entry
C27C1_HUMAN
resolver
uniprot_sec
A0A590UJ17
resolver
uniprot_sec
Q6ZNI7
resolver
amino_acid_sequence
MQTSAMALLARILRAGLRPAPERGGLLGGGAPRRPQPAGARLPAGARAEDKGAGRPGSPPGGGRAEGPRSLAAMPGPRTLANLAEFFCRDGFSRIHEIQQKHTREYGKIFKSHFGPQFVVSIADRDMVAQVLRAEGAAPQRANMESWREYRDLRGRATGLISAEGEQWLKMRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVRFVNRK
uniprot
proteins
ec_number
1.14.19.53
uniprot
proteins
function
FUNCTION: [Isoform 2]: A cytochrome P450 monooxygenase that catalyzes the 3,4 desaturation of all-trans-retinol (also called vitamin A1) to all-trans-3,4-didehydroretinol (also called vitamin A2) in the skin. Desaturates with lower efficiency all-trans retinal and all-trans retinoic acid. Forms minor amounts of 3-hydroxy and 4-hydroxy all-trans-retinol derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). {ECO:0000269|PubMed:27059013, ECO:0000269|PubMed:28701464}.
uniprot
proteins
mass_dalton
60920
uniprot
proteins
pathway_participation
PATHWAY: [Isoform 2]: Cofactor metabolism; retinol metabolism. {ECO:0000269|PubMed:27059013, ECO:0000269|PubMed:28701464}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
11181995
uniprot
proteins
pubmed
12477932
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16360114
uniprot
proteins
pubmed
27059013
uniprot
proteins
pubmed
28701464
uniprot
proteins
sequence_length
542
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion membrane {ECO:0000250|UniProtKB:P14137}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14137}.
uniprot
proteins