BDH2
entrez
56898
canonical
uniprot
Q9BUT1
canonical
ensembl
ENSG00000164039
resolver
ensp
ENSP00000296424
resolver
ensp
ENSP00000548138
resolver
ensp
ENSP00000548140
resolver
ensp
ENSP00000548143
resolver
ensp
ENSP00000548145
resolver
genesymbol
BDH2
resolver
genesymbol_syn
DHRS6
resolver
genesymbol_syn
SDR15C1
resolver
hgnc
HGNC:32389
resolver
uniprot
A8K295
resolver
uniprot
B4DUF6
resolver
uniprot
Q503A0
resolver
uniprot
Q6IA46
resolver
uniprot
Q6UWD3
resolver
uniprot
Q9H8S8
resolver
uniprot
Q9NRX8
resolver
uniprot_entry
DHRS6_HUMAN
resolver
uniprot_sec
A8K295
resolver
uniprot_sec
B4DUF6
resolver
uniprot_sec
Q503A0
resolver
uniprot_sec
Q6IA46
resolver
uniprot_sec
Q6UWD3
resolver
uniprot_sec
Q9H8S8
resolver
uniprot_sec
Q9NRX8
resolver
amino_acid_sequence
MGRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVTKKKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYVTGNPVIIDGGWSL
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
ec_number
1.1.1.104
uniprot
proteins
ec_number
1.1.1.30
uniprot
proteins
function
FUNCTION: NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (By similarity) (PubMed:35150746). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines (PubMed:35150746). Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (By similarity). May act as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372). {ECO:0000250|UniProtKB:Q8JZV9, ECO:0000269|PubMed:16380372, ECO:0000269|PubMed:35150746}.
uniprot
proteins
mass_dalton
26724
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid metabolism. {ECO:0000305|PubMed:35150746}.; PATHWAY: Siderophore biosynthesis. {ECO:0000250|UniProtKB:Q8JZV9}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16380372
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22527885
uniprot
proteins
pubmed
35150746
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16380372}.
uniprot
proteins