MXRA8
entrez
54587
canonical
uniprot
Q9BRK3
canonical
ensembl
ENSG00000162576
resolver
ensp
ENSP00000307887
resolver
ensp
ENSP00000344998
resolver
ensp
ENSP00000399229
resolver
ensp
ENSP00000436135
resolver
ensp
ENSP00000663448
resolver
ensp
ENSP00000720024
resolver
genesymbol
MXRA8
resolver
hgnc
HGNC:7542
resolver
uniprot
B3KTR6
resolver
uniprot
B4DE34
resolver
uniprot
Q5TA39
resolver
uniprot
Q96KC3
resolver
uniprot_entry
MXRA8_HUMAN
resolver
uniprot_sec
B3KTR6
resolver
uniprot_sec
B4DE34
resolver
uniprot_sec
Q5TA39
resolver
uniprot_sec
Q96KC3
resolver
amino_acid_sequence
MALPSRILLWKLVLLQSSAVLLHSGSSVPAAAGSSVVSESAVSWEAGARAVLRCQSPRMVWTQDRLHDRQRVLHWDLRGPGGGPARRLLDLYSAGEQRVYEARDRGRLELSASAFDDGNFSLLIRAVEETDAGLYTCNLHHHYCHLYESLAVRLEVTDGPPATPAYWDGEKEVLAVARGAPALLTCVNRGHVWTDRHVEEAQQVVHWDRQPPGVPHDRADRLLDLYASGERRAYGPLFLRDRVAVGADAFERGDFSLRIEPLEVADEGTYSCHLHHHYCGLHERRVFHLTVAEPHAEPPPRGSPGNGSSHSGAPGPDPTLARGHNVINVIVPESRAHFFQQLGYVLATLLLFILLLVTVLLAARRRRGGYEYSDQKSGKSKGKDVNLAEFAVAAGDQMLYRSEDIQLDYKNNILKERAELAHSPLPAKYIDLDKGFRKENCK
uniprot
proteins
function
FUNCTION: Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:22492581, PubMed:23386276). Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By similarity). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (By similarity). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (PubMed:23386276). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (PubMed:23386276). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (PubMed:23386276). May play a role in the maturation and maintenance of the blood-brain barrier (By similarity). {ECO:0000250|UniProtKB:Q9DBV4, ECO:0000269|PubMed:22492581, ECO:0000269|PubMed:23386276}.; FUNCTION: (Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses. {ECO:0000269|PubMed:29769725, ECO:0000269|PubMed:31080063}.
uniprot
proteins
mass_dalton
49132
uniprot
proteins
pubmed
14603461
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
22492581
uniprot
proteins
pubmed
23386276
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
29769725
uniprot
proteins
pubmed
31080063
uniprot
proteins
sequence_length
442
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23386276}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9DBV4}. Cytoplasm {ECO:0000250|UniProtKB:Q9DBV4}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q9DBV4}. Nucleus {ECO:0000269|PubMed:23386276}. Note=Primarily localizes to the cell membrane (PubMed:23386276). Detected in the cilium of primary chondrocytes (By similarity). Highly expressed at areas of cell-cell contact and may localize to tight junctions (By similarity). Also found in the nucleus where it is detected in the soluble (as opposed to chromatin-bound) fraction (PubMed:23386276). {ECO:0000250|UniProtKB:Q9DBV4, ECO:0000269|PubMed:23386276}.
uniprot
proteins
transmembrane_region
TRANSMEM 342..362; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins