TUT7
entrez
79670
canonical
uniprot
Q5VYS8
canonical
ensembl
ENSG00000083223
resolver
ensp
ENSP00000277141
resolver
ensp
ENSP00000365127
resolver
ensp
ENSP00000365130
resolver
ensp
ENSP00000566557
resolver
ensp
ENSP00000566558
resolver
ensp
ENSP00000641653
resolver
ensp
ENSP00000641654
resolver
ensp
ENSP00000676762
resolver
ensp
ENSP00000781062
resolver
enst
ENST00000277141
resolver
genesymbol
TUT7
resolver
genesymbol
ZCCHC6
resolver
genesymbol_syn
HS2
resolver
genesymbol_syn
KIAA1711
resolver
genesymbol_syn
ZCCHC6
resolver
hgnc
HGNC:25817
resolver
uniprot
Q5H9T0
resolver
uniprot
Q5VYS5
resolver
uniprot
Q5VYS7
resolver
uniprot
Q658Z9
resolver
uniprot
Q659A2
resolver
uniprot
Q6MZJ3
resolver
uniprot
Q8N5F0
resolver
uniprot
Q96KX5
resolver
uniprot
Q96N57
resolver
uniprot
Q96NE8
resolver
uniprot
Q9C0F2
resolver
uniprot
Q9H8M6
resolver
uniprot
X6R3Q3
resolver
uniprot_entry
Q96KX5_HUMAN
resolver
uniprot_entry
TUT7_HUMAN
resolver
uniprot_entry
X6R3Q3_HUMAN
resolver
uniprot_sec
Q5H9T0
resolver
uniprot_sec
Q5VYS5
resolver
uniprot_sec
Q5VYS7
resolver
uniprot_sec
Q658Z9
resolver
uniprot_sec
Q659A2
resolver
uniprot_sec
Q6MZJ3
resolver
uniprot_sec
Q8N5F0
resolver
uniprot_sec
Q96N57
resolver
uniprot_sec
Q96NE8
resolver
uniprot_sec
Q9C0F2
resolver
uniprot_sec
Q9H8M6
resolver
amino_acid_sequence
MGDTAKPYFVKRTKDRGTMDDDDFRRGHPQQDYLIIDDHAKGHGSKMEKGLQKKKITPGNYGNTPRKGPCAVSSNPYAFKNPIYSQPAWMNDSHKDQSKRWLSDEHTGNSDNWREFKPGPRIPVINRQRKDSFQENEDGYRWQDTRGCRTVRRLFHKDLTSLETTSEMEAGSPENKKQRSRPRKPRKTRNEENEQDGDLEGPVIDESVLSTKELLGLQQAEERLKRDCIDRLKRRPRNYPTAKYTCRLCDVLIESIAFAHKHIKEKRHKKNIKEKQEEELLTTLPPPTPSQINAVGIAIDKVVQEFGLHNENLEQRLEIKRIMENVFQHKLPDCSLRLYGSSCSRLGFKNSDVNIDIQFPAIMSQPDVLLLVQECLKNSDSFIDVDADFHARVPVVVCREKQSGLLCKVSAGNENACLTTKHLTALGKLEPKLVPLVIAFRYWAKLCSIDRPEEGGLPPYVFALMAIFFLQQRKEPLLPVYLGSWIEGFSLSKLGNFNLQDIEKDVVIWEHTDSAAGDTGITKEEAPRETPIKRGQVSLILDVKHQPSVPVGQLWVELLRFYALEFNLADLVISIRVKELVSRELKDWPKKRIAIEDPYSVKRNVARTLNSQPVFEYILHCLRTTYKYFALPHKITKSSLLKPLNAITCISEHSKEVINHHPDVQTKDDKLKNSVLAQGPGATSSAANTCKVQPLTLKETAESFGSPPKEEMGNEHISVHPENSDCIQADVNSDDYKGDKVYHPETGRKNEKEKVGRKGKHLLTVDQKRGEHVVCGSTRNNESESTLDLEGFQNPTAKECEGLATLDNKADLDGESTEGTEELEDSLNHFTHSVQGQTSEMIPSDEEEEDDEEEEEEEEPRLTINQREDEDGMANEDELDNTYTGSGDEDALSEEDDELGEAAKYEDVKECGKHVERALLVELNKISLKEENVCEEKNSPVDQSDFFYEFSKLIFTKGKSPTVVCSLCKREGHLKKDCPEDFKRIQLEPLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESFIRQDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGLETAEGLDCVRTIEELARVLRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSAYSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRNPPVIPVLQEIYKGEKKPEIFVDGWNIYFFDQIDELPTYWSECGKNTESVGQLWLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWTSKYIVIEDPFDLNHNLGAGLSRKMTNFIMKAFINGRRVFGIPVKGFPKDYPSKMEYFFDPDVLTEGELAPNDRCCRICGKIGHFMKDCPMRRKVRRRRDQEDALNQRYPENKEKRSKEDKEIHNKYTEREVSTKEDKPIQCTPQKAKPMRAAADLGREKILRPPVEKWKRQDDKDLREKRCFICGREGHIKKECPQFKGSSGSLSSKYMTQGKASAKRTQQES
uniprot
proteins
ec_number
2.7.7.52
uniprot
proteins
function
FUNCTION: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:18172165, PubMed:19703396, PubMed:22898984, PubMed:25480299, PubMed:25979828, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:Q5BLK4, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22898984, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:28671666, ECO:0000269|PubMed:30122351}.
uniprot
proteins
mass_dalton
171229
uniprot
proteins
mutagenesis
MUTAGEN 1060; /note="D->A: Abolishes inhibition of LIRE1 retrotransposition."; /evidence="ECO:0000269|PubMed:30122351"; MUTAGEN 1097..1099; /note="LPI->WPW: Abolishes monouridylation activity."; /evidence="ECO:0000269|PubMed:28671666
uniprot
proteins
protein_family
DNA polymerase type-B-like family
uniprot
proteins
pubmed
11214970
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17353264
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18172165
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19703396
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22898984
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25480299
uniprot
proteins
pubmed
25979828
uniprot
proteins
pubmed
28671666
uniprot
proteins
pubmed
30122351
uniprot
proteins
sequence_length
1495
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:30122351}. Note=Expression is pancytoplasmic in contrast with TUT4 expression which is enriched in cytoplasmic ribonucleoprotein granules. {ECO:0000269|PubMed:30122351}.
uniprot
proteins