NPS
entrez
594857
canonical
uniprot
P0C0P6
canonical
ensembl
ENSG00000214285
resolver
ensp
ENSP00000381105
resolver
enst
ENST00000398023
resolver
genesymbol
NPS
resolver
hgnc
HGNC:33940
resolver
uniprot_entry
NPS_HUMAN
resolver
amino_acid_sequence
MISSVKLNLILVLSLSTMHVFWCYPVPSSKVSGKSDYFLILLNSCPTRLDRSKELAFLKPILEKMFVKRSFRNGVGTGMKKTSFQRAKS
uniprot
proteins
function
FUNCTION: Ligand for NPSR1 (PubMed:15312648, PubMed:15947423, PubMed:16720571, PubMed:16790440). Binds to its receptor with nanomolar affinity and initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway. This results in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels (PubMed:15312648, PubMed:15947423, PubMed:16720571, PubMed:16790440, PubMed:25714705, PubMed:26865629). In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction (PubMed:26865629). Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade (PubMed:26865629). Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). {ECO:0000250|UniProtKB:P0C0P8, ECO:0000269|PubMed:15312648, ECO:0000269|PubMed:15947423, ECO:0000269|PubMed:16720571, ECO:0000269|PubMed:16790440, ECO:0000269|PubMed:25714705, ECO:0000269|PubMed:26865629}.
uniprot
proteins
mass_dalton
10103
uniprot
proteins
mutagenesis
MUTAGEN 70..79; /note="Missing: Loss of receptor activation and lack of Ca(2+) intracellular increase."; /evidence="ECO:0000269|PubMed:16720571"; MUTAGEN 70..71; /note="Missing: Loss of receptor activation and lack of Ca(2+) intracellular increase."; /evidence="ECO:0000269|PubMed:16720571"; MUTAGEN 70; /note="S->A: Does not affect receptor activation and Ca(2+) intracellular increase."; /evidence="ECO:0000269|PubMed:16720571"; MUTAGEN 70; /note="Missing: Does not affect receptor activation and Ca(2+) intracellular increase."; /evidence="ECO:0000269|PubMed:16720571"; MUTAGEN 71; /note="F->A: Loss of receptor activation and lack of Ca(2+) intracellular increase."; /evidence="ECO:0000269|PubMed:16720571"; MUTAGEN 80..89; /note="Missing: Does not affect receptor activation and Ca(2+) intracellular increase."; /evidence="ECO:0000269|PubMed:16720571
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15312648
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15947423
uniprot
proteins
pubmed
16720571
uniprot
proteins
pubmed
16790440
uniprot
proteins
pubmed
25714705
uniprot
proteins
pubmed
26865629
uniprot
proteins
sequence_length
89
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C0P7}.
uniprot
proteins