Gucy1b1
entrez
54195
canonical
uniprot
O54865
canonical
ensembl
ENSMUSG00000028005
resolver
ensp
ENSMUSP00000029635
resolver
ensp
ENSMUSP00000142119
resolver
enst
ENSMUST00000029635
resolver
enst
ENSMUST00000193597
resolver
genesymbol
Gucy1b1
resolver
genesymbol_syn
Gucy1b3
resolver
uniprot
A0A0A6YXS6
resolver
uniprot
Q3UTI4
resolver
uniprot
Q80YP4
resolver
uniprot_entry
A0A0A6YXS6_MOUSE
resolver
uniprot_entry
GCYB1_MOUSE
resolver
uniprot_entry
Q3UTI4_MOUSE
resolver
uniprot_entry
Q80YP4_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by nitric oxide in the presence of magnesium or manganese ions. NO binding to the haem of the beta subunit GUCY1B1 induces a conformational change that allosterically activates the catalytic domain. {ECO:0000250|UniProtKB:Q02153}.
uniprot
proteins
amino_acid_sequence
MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRNLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGAEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPLFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETNEEDEN
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Beta subunit of soluble guanylate cyclase (sGC), a key enzyme in nitric oxide (NO) signaling. sGC functions as a heterodimer consisting of one alpha and one beta subunit. It serves as the primary intracellular receptor for NO, which binds to a heme prosthetic group located on the beta subunit. Upon NO binding, sGC catalyzes the conversion of GTP into cyclic GMP (cGMP), thereby transmitting the NO signal into an ubiquitous intracellular second messenger. {ECO:0000250|UniProtKB:Q02153}.
uniprot
proteins
mass_dalton
70598
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
10984516
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
620
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P16068}.
uniprot
proteins