Ifit3
entrez
15959
canonical
uniprot
Q64345
canonical
ensembl
ENSMUSG00000074896
resolver
ensp
ENSMUSP00000099889
resolver
enst
ENSMUST00000102825
resolver
genesymbol
Ifit3
resolver
genesymbol_syn
Garg49
resolver
genesymbol_syn
Ifi49
resolver
genesymbol_syn
Isg49
resolver
uniprot
Q5FW82
resolver
uniprot
Q99L62
resolver
uniprot_entry
IFIT3_MOUSE
resolver
uniprot_entry
Q5FW82_MOUSE
resolver
uniprot_sec
Q99L62
resolver
amino_acid_sequence
MSEVNRESLEAILPQLKCHFTWNLFREGSMSSHMEDRVCNQVEHLNSEEKATMYDLLAYIKHLDGESKAALECLGQAEDLRKSEHNDQSEIRRLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANPYSMECPELECEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEKQFSVDALKQAMELNPQNQYLKVLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSPLYSLVMCRYREILEQLQNKGDADSSERRQRMAELRRLTMEFMQKTLQRRRSPLNSYSDLIDFPEVERCYQMVISKESPDVEEEDLYERYCNLQEYHRKSEDLAALECLLQFPRNERSIEKEEVKEQT
uniprot
proteins
function
FUNCTION: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
47223
uniprot
proteins
protein_family
IFIT family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20950130
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32731337
uniprot
proteins
pubmed
8207206
uniprot
proteins
pubmed
8660659
uniprot
proteins
sequence_length
403
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O14879}. Mitochondrion {ECO:0000250|UniProtKB:O14879}.
uniprot
proteins