Phax
entrez
56698
canonical
uniprot
Q9JJT9
canonical
ensembl
ENSMUSG00000008301
resolver
ensp
ENSMUSP00000008445
resolver
ensp
ENSMUSP00000122948
resolver
enst
ENSMUST00000008445
resolver
enst
ENSMUST00000130163
resolver
genesymbol
Phax
resolver
genesymbol_syn
Rnuxa
resolver
uniprot
G5E8V8
resolver
uniprot
Q8BSR8
resolver
uniprot_entry
G5E8V8_MOUSE
resolver
uniprot_entry
PHAX_MOUSE
resolver
uniprot_sec
Q8BSR8
resolver
amino_acid_sequence
MALEAGDMEEGQLSDSDSDMTVVPSDRPLQMAKVLGGGSAACAPVSHYRTVKHVDSSEESLDSDDDCSLWKRKRQKCHNTPPKPEPFPFGPSGQKTALNGGKKVNNIWGAVLQEQNQDAVATELGILGMEGSIDRSRQSETYNYLLAKKLAKKESQEYTKELDKDLDEYMHGDKKPGSKEDENGQGHLKRKRPVRDRLGNRVEMNYKGRYEITEEDAPEKVADEIAFRLQEPKKDLIARVVRILGNKKAIELLMETAEVEQNGGLFIMNGSRRRTPGGVFLNLLKNTPSISEEQIKDIFYVENQKEYENKKAARKRRTQLLGKKMKQAIKSLNFQEDDDTSRETFASDTNEALASLDEAQEGPGETKLDAEEAIEVDHPQDLDIF
uniprot
proteins
function
FUNCTION: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:10786834, ECO:0000269|PubMed:11333016}.
uniprot
proteins
mass_dalton
43247
uniprot
proteins
mutagenesis
MUTAGEN 71..74; /note="KRKR->ARAA: Strongly reduces its import in the nucleus. Abolishes its import in the nucleus, does not change its export to the cytoplasm and the export of U snRNA complex; when associated with 190-AA-191."; /evidence="ECO:0000269|PubMed:11333016"; MUTAGEN 124..129; /note="LGILGM->AGIAGA: Reduces U snRNA export. Strongly abolishes the U snRNA export complex formation. Does not abolish the pre-complex formation."; /evidence="ECO:0000269|PubMed:10786834"; MUTAGEN 190..191; /note="RK->AA: Strongly reduces its import in the nucleus. Abolishes its import in the nucleus, does not change its export to the cytoplasm and the export of the U snRNA complex; when associated with 71-ARAA-74."; /evidence="ECO:0000269|PubMed:11333016"; MUTAGEN 255..258; /note="ETAE->AAAA: Does not inhibit URNA-binding."; /evidence="ECO:0000269|PubMed:11333016"; MUTAGEN 260..262; /note="EQN->AAA: Partially inhibits URNA-binding."; /evidence="ECO:0000269|PubMed:11333016"; MUTAGEN 263..264; /note="GG->AA: Strongly inhibits URNA-binding."; /evidence="ECO:0000269|PubMed:11333016"; MUTAGEN 270..271; /note="GS->AA: Partially inhibits URNA-binding."; /evidence="ECO:0000269|PubMed:11333016"; MUTAGEN 273..274; /note="RR->AA: Partially reduces its import in the nucleus."; /evidence="ECO:0000269|PubMed:11333016"; MUTAGEN 275..276; /note="TP->AA: Partially inhibits URNA-binding."; /evidence="ECO:0000269|PubMed:11333016"; MUTAGEN 289..293; /note="SISEE->AIAEA: Does not inhibit URNA-binding."; /evidence="ECO:0000269|PubMed:11333016"; MUTAGEN 315..316; /note="KR->AA: Partially reduces its import in the nucleus."; /evidence="ECO:0000269|PubMed:11333016
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in the nucleus. Dephosphorylated in the cytoplasm. {ECO:0000269|PubMed:10786834}.
uniprot
proteins
protein_family
PHAX family
uniprot
proteins
pubmed
10786834
uniprot
proteins
pubmed
11333016
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H814}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9H814}. Nucleus, Cajal body {ECO:0000250|UniProtKB:Q9H814}. Cytoplasm {ECO:0000269|PubMed:10786834}. Note=Shuttles between the nucleus and the cytoplasm. Shuttles between the nucleoplasm and Cajal bodies. {ECO:0000250|UniProtKB:Q9H814}.
uniprot
proteins