A0A087WRU1
uniprot
A0A087WRU1
canonical
amino_acid_sequence
MNWVGGSRSRVLIKQERRKQKEYFERNKLKSKLKLLGVVSPVKKPSVSLDLLNLYVVNQISSMKENSETMKRPTHVNMTRDLKVPLRKHDLELPMSPHCVPSKLCIDDMEDSVPYQRIYSKEETGPVQSSQDMKSYRMFNETGNCSYIPPSFPEELRSNRHIRSQHSTPRIGPSPQQFVYENPHSGQFSNGKFPESLFSKLNKHQHVFSSSQTTAEFEAPYKRTNSSETGDFLTKRSMIMGEDCRSLYERRQPDFAMEKPLVQQIYANNGEEFSNFLEDVIHPTQRHLPDNHNSFVSHSMIDLLSKDQPGRRATFTKCGYDSLSDTHVVSSDESHSSSGLINGEFTVPQATSPNFPFNTSYTETCQPNRPCQEYNSNEINEFRRSFEKDCYSIGCGRKGKIESDKQLKELQRNARKHPVYTMADIPLEELHCKQSCDFDQNEIPMERRGMCPLKGQPMSTEKIYLESSQSSQSASYSPRPTESTFSSSTDLISEDEDQIQQQTEDSNKKATETTGNCCLEKMENHFDDITVKDDATAHKQNHKCLQSSEKNNADAFPESQCNSEHTVQNKSTDNCVLQAGRCDVGVQTEEAPLVGNTADVAVQCTIITRCSCMSSPVLIREKESSHPEAGSCTEDRTADTTGGQETPTSNSL
uniprot
proteins
function
FUNCTION: Involved in recombination, probably acting by stabilizing recombination intermediates during meiotic crossover formation (PubMed:37604834, PubMed:37612290). Required for normal germline development and fertility (PubMed:37604834, PubMed:37612290). Required for meiotic progression, complete chromosomal synapsis and crossover formation (PubMed:37604834, PubMed:37612290). Binds double-stranded DNA (PubMed:37604834). However, also binds branched DNA molecules, such as those containing a D-loop or Holliday junction structure (PubMed:37612290). Probably not required for formation of DNA double-strand breaks (DSBs) (PubMed:37604834). Also binds RNA in an RNA structure-independent manner, with a preference for binding 3'-UTR regions of mRNAs; may stabilize bound RNAs (PubMed:37604834). {ECO:0000269|PubMed:37604834, ECO:0000269|PubMed:37612290}.
uniprot
proteins
mass_dalton
73811
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
37604834
uniprot
proteins
pubmed
37612290
uniprot
proteins
sequence_length
652
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:37612290}. Note=In pachytene spermatocytes, localized along autosomal axes and the synapsed pseudoautosomal region on sex chromosomes, decreasing rapidly after early pachytene, by mid- or late pachytene, and disappearing in the diplotene stage (PubMed:37612290). Also detected on the paired regions of homologous chromosomes in zygotene and pachytene oocytes, colocalizing with MSH4 (PubMed:37612290). Chromosomal localization of REDIC1 is mainly dependent on meiotic DNA double-strand breaks (DSBs) and interhomolog strand invasion (PubMed:37612290). In spermatocytes from early zygotene to early pachytene, more than 90% of REDIC1 foci colocalize with RPA2 (PubMed:37612290). Probably localizes first to recombination intermediates and later colocalizes with MLH1 at crossover sites (PubMed:37612290). {ECO:0000269|PubMed:37612290}.
uniprot
proteins