TFAP2C
entrez
7022
canonical
uniprot
Q92754
canonical
ensembl
ENSG00000087510
resolver
ensp
ENSP00000201031
resolver
genesymbol
TFAP2C
resolver
hgnc
HGNC:11744
resolver
uniprot
B4DWK3
resolver
uniprot
O00685
resolver
uniprot
O00730
resolver
uniprot
Q86V30
resolver
uniprot
Q8IVB6
resolver
uniprot
Q9P1X2
resolver
uniprot_entry
AP2C_HUMAN
resolver
uniprot_sec
B4DWK3
resolver
uniprot_sec
O00685
resolver
uniprot_sec
O00730
resolver
uniprot_sec
Q86V30
resolver
uniprot_sec
Q8IVB6
resolver
uniprot_sec
Q9P1X2
resolver
amino_acid_sequence
MLWKITDNVKYEEDCEDRHDGSSNGNPRVPHLSSAGQHLYSPAPPLSHTGVAEYQPPPYFPPPYQQLAYSQSADPYSHLGEAYAAAINPLHQPAPTGSQQQAWPGRQSQEGAGLPSHHGRPAGLLPHLSGLEAGAVSARRDAYRRSDLLLPHAHALDAAGLAENLGLHDMPHQMDEVQNVDDQHLLLHDQTVIRKGPISMTKNPLNLPCQKELVGAVMNPTEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAHVTLLTSLVEGEAVHLARDFAYVCEAEFPSKPVAEYLTRPHLGGRNEMAARKNMLLAAQQLCKEFTELLSQDRTPHGTSRLAPVLETNIQNCLSHFSLITHGFGSQAICAAVSALQNYIKEALIVIDKSYMNPGDQSPADSNKTLEKMEKHRK
uniprot
proteins
function
FUNCTION: Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:Q61312, ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}.
uniprot
proteins
mass_dalton
49177
uniprot
proteins
mutagenesis
MUTAGEN 59; /note="Y->A: Loss of interaction with WWOX; when associated with A-64."; /evidence="ECO:0000269|PubMed:15548692"; MUTAGEN 64; /note="Y->A: Loss of interaction with WWOX; when associated with A-59."; /evidence="ECO:0000269|PubMed:15548692
uniprot
proteins
post_translational_modification
PTM: Sumoylated on Lys-10; which inhibits transcriptional activity. {ECO:0000269|PubMed:12072434}.
uniprot
proteins
protein_family
AP-2 family
uniprot
proteins
pubmed
11694877
uniprot
proteins
pubmed
11744733
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12072434
uniprot
proteins
pubmed
12586840
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15548692
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19115315
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24413532
uniprot
proteins
pubmed
8661133
uniprot
proteins
pubmed
9113991
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24413532}.
uniprot
proteins