Ctu1
entrez
233189
canonical
uniprot
Q99J10
canonical
ensembl
ENSMUSG00000038888
resolver
ensp
ENSMUSP00000036770
resolver
enst
ENSMUST00000038332
resolver
genesymbol
Ctu1
resolver
genesymbol_syn
Atpbd3
resolver
genesymbol_syn
Ncs6
resolver
uniprot_entry
CTU1_MOUSE
resolver
amino_acid_sequence
MPAPTCFSCHKTRAALRRPRSGQALCGSCFCAAFEAEVLHTVLAGHLLPPGAVVAVGASGGKDSTVLAHVLRELAPRLGITLHLVAVDEGIGGYRDAALEAVRSQAARWELPLTIVAYEDLFGGWTMDAVARSTAGSGRSRSCCTFCGVLRRRALEEGARLVGATHIVTGHNADDMAETVLMNFLRGDAGRLARGGVLGSTGEGCALPRCRPLQFASQKEVVLYAHFRHLRYFSEECVYAPEAFRGHARDLLKLLEAARPSAVLDLVHSAERLALAPAAKPPPPGTCSRCGALASHKLCQACALLDGLNRGLPRLAIGKGRRVLQVEPPQPGNPSLVTSDPVAPAGPCTCKQPKDKANPCGNGGDRAGATCVSQCDLSPGNGEDRAGATCVSQRDLSLGNGGDRAGATCVSQCDLSPVAE
uniprot
proteins
ec_number
2.7.7.-
uniprot
proteins
function
FUNCTION: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255|HAMAP-Rule:MF_03053}.
uniprot
proteins
mass_dalton
43823
uniprot
proteins
pathway_participation
PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03053}.
uniprot
proteins
protein_family
CTU1/NCS6/ATPBD3 subfamily
uniprot
proteins
protein_family
TtcA family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03053}.
uniprot
proteins