Ccr3
entrez
117027
canonical
uniprot
O54814
canonical
ensembl
ENSRNOG00000006736
resolver
ensp
ENSRNOP00000008809
resolver
ensp
ENSRNOP00000093164
resolver
ensp
ENSRNOP00000103876
resolver
ensp
ENSRNOP00000105067
resolver
ensp
ENSRNOP00000110031
resolver
enst
ENSRNOT00000008809
resolver
enst
ENSRNOT00000119301
resolver
enst
ENSRNOT00000121928
resolver
enst
ENSRNOT00000131707
resolver
genesymbol
Ccr3
resolver
genesymbol_syn
Cmkbr3
resolver
uniprot
A0A0A0MXU9
resolver
uniprot
O55169
resolver
uniprot_entry
A0A0A0MXU9_RAT
resolver
uniprot_entry
CCR3_RAT
resolver
uniprot_sec
O55169
resolver
amino_acid_sequence
MASNEEELKTVVETFETTPYEYEWAPPCEKVSIRELGSWLLPPLYSLVFIVGLLGNMMVVLILIKYRKLQIMTNIYLLNLAISDLLFLFTVPFWIHYVLWNEWGFGHCMCKMLSGLYYLALYSEIFFIILLTIDRYLAIVHAVLALRARTVTFATITSIITWGFAVLAALPEFIFHESQDNFGDLSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLIMVICYSGIIKTLLRCPNKKKHKAIQLIFVVMIVFFIFWTPYNLVLLLSAFHSTFLETSCQQSIHLDLAMQVTEVITHTHCCINPIIYAFVGERFRKHLRLFFHRNVAIYLRKYISFLPGEKLERTSSVSPSTGEQEISVVF
uniprot
proteins
function
FUNCTION: G protein-coupled receptor (GPCR) that plays a key role in the immune system by regulating the migration and activation of white blood cells in response to chemokines. Selectively interacts with eosinophil-attracting chemokines such as eotaxin/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. Ligand binding triggers intracellular signaling that leads to chemotaxis of immune cells. Mechanistically, signals through GNA14 or GNA16 to induce stimulation of phospholipase Cbeta/PLCB2 and subsequently chemotaxis. Alternatively, transduces signal via GNAI1 resulting in elevated intracellular calcium levels and activation of the PI3K/AKT pathway. May also act as a possible functional receptor for NARS1. {ECO:0000250|UniProtKB:P51677}.
uniprot
proteins
mass_dalton
41643
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
9655467
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..64; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 75..95; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 244..264; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins