NRDE2
entrez
55051
canonical
uniprot
Q9H7Z3
canonical
ensembl
ENSG00000119720
resolver
ensp
ENSP00000346335
resolver
enst
ENST00000354366
resolver
genesymbol
NRDE2
resolver
genesymbol_syn
C14orf102
resolver
hgnc
HGNC:20186
resolver
uniprot
B4DH71
resolver
uniprot
Q4G0A7
resolver
uniprot
Q9NWH6
resolver
uniprot_entry
NRDE2_HUMAN
resolver
uniprot_sec
B4DH71
resolver
uniprot_sec
Q4G0A7
resolver
uniprot_sec
Q9NWH6
resolver
amino_acid_sequence
MALFPAFAGLSEAPDGGSSRKELDWLSNPSFCVGSITSLSQQTEAAPAHVSEGLPLTRSHLKSESSDESDTNKKLKQTSRKKKKEKKKKRKHQHHKKTKRKHGPSSSSRSETDTDSEKDKPSRGVGGSKKESEEPNQGNNAAADTGHRFVWLEDIQAVTGETFRTDKKPDPANWEYKSLYRGDIARYKRKGDSCLGINPKKQCISWEGTSTEKKHSRKQVERYFTKKSVGLMNIDGVAISSKTEPPSSEPISFIPVKDLEDAAPVTTWLNPLGIYDQSTTHWLQGQGPPEQESKQPDAQPDSESAALKAKVEEFNRRVRENPRDTQLWMAFVAFQDEVMKSPGLYAIEEGEQEKRKRSLKLILEKKLAILERAIESNQSSVDLKLAKLKLCTEFWEPSTLVKEWQKLIFLHPNNTALWQKYLLFCQSQFSTFSISKIHSLYGKCLSTLSAVKDGSILSHPALPGTEEAMFALFLQQCHFLRQAGHSEKAISLFQAMVDFTFFKPDSVKDLPTKGQVEFFEPFWDSGEPRAGEKGARGWKAWMHQQERGGWVVINPDEDDDEPEEDDQEIKDKTLPRWQIWLAAERSRDQRHWRPWRPDKTKKQTEEDCEDPERQVLFDDIGQSLIRLSSHDLQFQLVEAFLQFLGVPSGFTPPASCLYLAMDENSIFDNGLYDEKPLTFFNPLFSGASCVGRMDRLGYPRWTRGQNREGEEFIRNVFHLVMPLFSGKEKSQLCFSWLQYEIAKVIWCLHTKNKKRLKSQGKNCKKLAKNLLKEPENCNNFCLWKQYAHLEWLLGNTEDARKVFDTALGMAGSRELKDSDLCELSLLYAELEVELSPEVRRAATARAVHILTKLTESSPYGPYTGQVLAVHILKARKAYEHALQDCLGDSCVSNPAPTDSCSRLISLAKCFMLFQYLTIGIDAAVQIYEQVFAKLNSSVFPEGSGEGDSASSQSWTSVLEAITLMHTSLLRFHMKVSVYPLAPLREALSQALKLYPGNQVLWRSYVQIQNKSHSASKTRRFFDTITRSAKPLEPWLFAIEAEKLRKRLVETVQRLDGREIHATIPETGLMHRIQALFENAMRSDSGSQCPLLWRMYLNFLVSLGNKERSKGVFYKALQNCPWAKVLYLDAVEYFPDEMQEILDLMTEKELRVRLPLEELELLLED
uniprot
proteins
function
FUNCTION: Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217). U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis (PubMed:30538148). Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites (PubMed:30538148). Plays a role in DNA damage response (PubMed:29902117). {ECO:0000269|PubMed:29902117, ECO:0000269|PubMed:30538148, ECO:0000269|PubMed:30842217}.
uniprot
proteins
mass_dalton
132673
uniprot
proteins
mutagenesis
MUTAGEN 163; /note="F->A: Loss of interaction with MTREX associated with decreased RNAs stability; when associated with R-166; A-187 and E-189."; /evidence="ECO:0000269|PubMed:30842217"; MUTAGEN 166; /note="D->R: Loss of interaction with MTREX associated with decreased RNAs stability; when associated with A-163; A-187 and E-189."; /evidence="ECO:0000269|PubMed:30842217"; MUTAGEN 187; /note="Y->A: Loss of interaction with MTREX associated with decreased RNAs stability; when associated with A-163; R-166 and E-189."; /evidence="ECO:0000269|PubMed:30842217"; MUTAGEN 189; /note="R->E: Loss of interaction with MTREX associated with decreased RNAs stability; when associated with A-163; R-166 and A-187."; /evidence="ECO:0000269|PubMed:30842217
uniprot
proteins
protein_family
NRDE2 family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
29902117
uniprot
proteins
pubmed
30538148
uniprot
proteins
pubmed
30842217
uniprot
proteins
sequence_length
1164
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:30538148, ECO:0000269|PubMed:30842217}. Nucleus, nucleolus {ECO:0000269|PubMed:30842217}. Nucleus, nucleoplasm {ECO:0000269|PubMed:30538148, ECO:0000269|PubMed:30842217}. Nucleus {ECO:0000269|PubMed:29902117}.
uniprot
proteins