Gabra1
entrez
14394
canonical
uniprot
P62812
canonical
ensembl
ENSMUSG00000010803
resolver
ensp
ENSMUSP00000020707
resolver
ensp
ENSMUSP00000146133
resolver
ensp
ENSMUSP00000169740
resolver
enst
ENSMUST00000020707
resolver
enst
ENSMUST00000205546
resolver
genesymbol
Gabra1
resolver
genesymbol_syn
Gabra-1
resolver
uniprot
P18504
resolver
uniprot
Q3URD4
resolver
uniprot
Q544F7
resolver
uniprot_entry
GBRA1_MOUSE
resolver
uniprot_entry
Q3URD4_MOUSE
resolver
uniprot_entry
Q544F7_MOUSE
resolver
uniprot_sec
P18504
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by benzodiazepines, the neuroanesthetic alphaxalone and pentobarbital (By similarity). Inhibited by the antagonist bicuculline (By similarity). Potentiated by histamine (By similarity). {ECO:0000250|UniProtKB:P14867, ECO:0000250|UniProtKB:P62813}.
uniprot
proteins
amino_acid_sequence
MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
uniprot
proteins
function
FUNCTION: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by Gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:27129275). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Alpha-1/GABRA1-containing GABAARs are largely synaptic (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:27129275). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (By similarity). GABAARs containing alpha, beta and epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (By similarity). Alpha-1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (PubMed:25348603). Together with rho subunits, may also control neuronal and glial GABAergic transmission in the cerebellum (PubMed:16945976, PubMed:25422464). {ECO:0000250|UniProtKB:P08219, ECO:0000250|UniProtKB:P62813, ECO:0000269|PubMed:16945976, ECO:0000269|PubMed:25348603, ECO:0000269|PubMed:25422464, ECO:0000269|PubMed:27129275}.
uniprot
proteins
mass_dalton
51754
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:27129275}.
uniprot
proteins
protein_family
GABRA1 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
12106288
uniprot
proteins
pubmed
1356407
uniprot
proteins
pubmed
16380713
uniprot
proteins
pubmed
16945976
uniprot
proteins
pubmed
1848528
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25348603
uniprot
proteins
pubmed
25422464
uniprot
proteins
pubmed
25579817
uniprot
proteins
pubmed
27129275
uniprot
proteins
pubmed
31601770
uniprot
proteins
sequence_length
455
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:16945976}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P14867}. Cell membrane {ECO:0000269|PubMed:16380713, ECO:0000269|PubMed:25422464, ECO:0000269|PubMed:25579817}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P14867}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P62813}. Note=Located at the plasma membrane of astrocytes (PubMed:25422464). Located in the somatic, proximal and distal dendritic regions of cerebellar Purkinje cells and in the molecular layer (PubMed:16945976). {ECO:0000269|PubMed:16945976, ECO:0000269|PubMed:25422464}.
uniprot
proteins
transmembrane_region
TRANSMEM 253..273; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P14867"; TRANSMEM 279..300; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P14867"; TRANSMEM 311..332; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P14867"; TRANSMEM 421..440; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P14867
uniprot
proteins