Gpr84
entrez
80910
canonical
uniprot
Q8CIM5
canonical
ensembl
ENSMUSG00000063234
resolver
ensp
ENSMUSP00000078753
resolver
ensp
ENSMUSP00000307527
resolver
enst
ENSMUST00000079824
resolver
genesymbol
Gpr84
resolver
uniprot
A0A0R4J100
resolver
uniprot
Q99MX9
resolver
uniprot_entry
A0A0R4J100_MOUSE
resolver
uniprot_entry
GPR84_MOUSE
resolver
uniprot_sec
Q99MX9
resolver
amino_acid_sequence
MWNSSDANFSCYHESVLGYRYFAVIWGVAVAVTGTVGNVLTLLALAIRPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGAVFCRIFGLLLFTSNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVGSWVVGVTSFAPLWNVFVLVPVVCTCSFDRMRGRPYTTILMGIYFVLGLSSVGVFYCLIHRQVKRAARALDQYGLHQASIRSHQVAGTQEAMPGHFQELDSGVASRGPSEGISSEPVSAATTQTLEGDSSEAGGQGIRKAAQQIAERSLPEVHRKPRETAGARRATDAPSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARGRAPRVVHMVAANLTWLNSCINPVLYAAMNRQFRHAYGSILKRGPQSFRRFH
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that responds endogenously to dietary fatty acids or nutrient, specifically medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists (By similarity). In immune cells, functions as a pro-inflammatory receptor via 6-OAU and promotes the expression of pro-inflammatory mediators such as TNFalpha, IL-6 and IL-12B as well as stimulating chemotactic responses through activation of signaling mediators AKT, ERK and NF-kappa-B (by sim). In addition, triggers increased bacterial adhesion and phagocytosis in macrophages and regulates pro-inflammatory function via enhancing NLRP3 inflammasome activation (PubMed:34912006). Also plays an important role in inflammation by modulating neutrophil functions (PubMed:37016043). Mechanistically, promotes neutrophil chemotaxis, reactive oxygen species (ROS) production and degranulation via LYN-AKT/ERK pathway (PubMed:37016043). To regulate ROS production, communicates with the two formyl peptide receptors FPR2 and FPR1 to control the NADPH oxidase activity in neutrophils (PubMed:29973940). {ECO:0000250|UniProtKB:Q9NQS5, ECO:0000269|PubMed:16966319}.
uniprot
proteins
mass_dalton
43717
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by a subset of GPR84-activating ligands. Constitutively phosphorylated at Ser-221 and Ser-224 in the absence of 2-HTP. By contrast, Thr-263 and Thr-264 are phosphorylated only following prior cell treatment with 2-HTP. {ECO:0000250|UniProtKB:Q9NQS5}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11273702
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16966319
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
29973940
uniprot
proteins
pubmed
34912006
uniprot
proteins
pubmed
37016043
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NQS5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NQS5}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 58..78; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 95..115; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 181..201; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 321..341; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 353..373; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins