TWF2
entrez
11344
canonical
uniprot
Q6IBS0
canonical
ensembl
ENSG00000247596
resolver
ensp
ENSP00000303908
resolver
enst
ENST00000305533
resolver
genesymbol
TWF2
resolver
genesymbol_syn
PTK9L
resolver
hgnc
HGNC:9621
resolver
uniprot
Q9Y3F5
resolver
uniprot_entry
TWF2_HUMAN
resolver
uniprot_sec
Q9Y3F5
resolver
amino_acid_sequence
MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQQPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSFAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPTDVAQLPSRVPRDAARYHFFLYKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAKKIEIGDGAELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRGHKRLIRGPGENGDDS
uniprot
proteins
function
FUNCTION: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
39548
uniprot
proteins
post_translational_modification
PTM: In vitro, phosphorylated by PRKCZ, CK2 and SRC. {ECO:0000269|PubMed:10406962}.
uniprot
proteins
protein_family
Actin-binding proteins ADF family
uniprot
proteins
protein_family
Twinfilin subfamily
uniprot
proteins
pubmed
10406962
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10406962}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10406962}. Cell projection, stereocilium {ECO:0000250}. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization.
uniprot
proteins