Eif2b3
entrez
171145
canonical
uniprot
P70541
canonical
ensembl
ENSRNOG00000018375
resolver
ensembl
ENSRNOG00055012550
resolver
ensembl
ENSRNOG00060029501
resolver
ensembl
ENSRNOG00065016905
resolver
ensp
ENSRNOP00000024841
resolver
ensp
ENSRNOP00000078465
resolver
ensp
ENSRNOP00000095520
resolver
ensp
ENSRNOP00055017322
resolver
ensp
ENSRNOP00060042746
resolver
ensp
ENSRNOP00065022356
resolver
enst
ENSRNOT00000024841
resolver
enst
ENSRNOT00000109617
resolver
enst
ENSRNOT00000111764
resolver
enst
ENSRNOT00055021407
resolver
enst
ENSRNOT00060051387
resolver
enst
ENSRNOT00065028288
resolver
genesymbol
Eif2b3
resolver
genesymbol_syn
Eif2bg
resolver
uniprot
A0A8I5ZKY2
resolver
uniprot
A0A8I6APB6
resolver
uniprot
Q6IN08
resolver
uniprot_entry
A0A8I5ZKY2_RAT
resolver
uniprot_entry
EI2BG_RAT
resolver
uniprot_sec
A0A8I6APB6
resolver
uniprot_sec
Q6IN08
resolver
activity_regulation
ACTIVITY REGULATION: Activated by the chemical integrated stress response (ISR) inhibitor ISRIB which stimulates guanine nucleotide exchange factor activity for both phosphorylated and unphosphorylated eIF2. {ECO:0000250|UniProtKB:Q9NR50}.
uniprot
proteins
amino_acid_sequence
MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVTTKDVQKALCAEFKMKLKPDIVCIPDEADMGTADSLRHIYPKLKTDVLVLGCDLITDVALHEVVDLFRAYDASLAMLMRKGQESTEPVPGQKGKKKTVEQRDFIGVDSTGKRLLFMANEADLDEELVIKGSILQKHPRIHFQTGLVDAHLYCLKKYVVDFLMENKSITSIRSELIPYLVRKQFSSASSQQRQEDKEEDLKKKEPKSLDIYSFIKKDNTLTLAPYDACWNAFRRDKWEDLSRSQVRCYVHIMKEGLCSRVSTLGLYMEANRQVPKLLSVLCPEESMIHPSAQIANKHLIGADSLIGSDTQVGEKSSIKRSVIGSSCVIRDRVTVTNCLLMNSVTVEEGSSIHGSVICNNAVVEAGAEIRDCLIGSGQRIEAKAKRMNEVIVGNDQLMEI
uniprot
proteins
function
FUNCTION: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed. {ECO:0000250|UniProtKB:Q9NR50}.
uniprot
proteins
mass_dalton
50435
uniprot
proteins
protein_family
EIF-2B gamma/epsilon subunits family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8809057
uniprot
proteins
sequence_length
452
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56288}.
uniprot
proteins