COLEC12
entrez
81035
canonical
uniprot
Q5KU26
canonical
ensembl
ENSG00000158270
resolver
ensp
ENSP00000383115
resolver
ensp
ENSP00000521857
resolver
enst
ENST00000400256
resolver
genesymbol
COLEC12
resolver
genesymbol_syn
CLP1
resolver
genesymbol_syn
NSR2
resolver
genesymbol_syn
SCARA4
resolver
genesymbol_syn
SRCL
resolver
hgnc
HGNC:16016
resolver
uniprot
Q6P9F2
resolver
uniprot
Q8TCR2
resolver
uniprot
Q8WZA4
resolver
uniprot
Q9BY85
resolver
uniprot
Q9BYH7
resolver
uniprot_entry
COL12_HUMAN
resolver
uniprot_sec
Q6P9F2
resolver
uniprot_sec
Q8TCR2
resolver
uniprot_sec
Q8WZA4
resolver
uniprot_sec
Q9BY85
resolver
uniprot_sec
Q9BYH7
resolver
amino_acid_sequence
MKDDFAEEEEVQSFGYKRFGIQEGTQCTKCKNNWALKFSIILLYILCALLTITVAILGYKVVEKMDNVTGGMETSRQTYDDKLTAVESDLKKLGDQTGKKAISTNSELSTFRSDILDLRQQLREITEKTSKNKDTLEKLQASGDALVDRQSQLKETLENNSFLITTVNKTLQAYNGYVTNLQQDTSVLQGNLQNQMYSHNVVIMNLNNLNLTQVQQRNLITNLQRSVDDTSQAIQRIKNDFQNLQQVFLQAKKDTDWLKEKVQSLQTLAANNSALAKANNDTLEDMNSQLNSFTGQMENITTISQANEQNLKDLQDLHKDAENRTAIKFNQLEERFQLFETDIVNIISNISYTAHHLRTLTSNLNEVRTTCTDTLTKHTDDLTSLNNTLANIRLDSVSLRMQQDLMRSRLDTEVANLSVIMEEMKLVDSKHGQLIKNFTILQGPPGPRGPRGDRGSQGPPGPTGNKGQKGEKGEPGPPGPAGERGPIGPAGPPGERGGKGSKGSQGPKGSRGSPGKPGPQGSSGDPGPPGPPGKEGLPGPQGPPGFQGLQGTVGEPGVPGPRGLPGLPGVPGMPGPKGPPGPPGPSGAVVPLALQNEPTPAPEDNGCPPHWKNFTDKCYYFSVEKEIFEDAKLFCEDKSSHLVFINTREEQQWIKKQMVGRESHWIGLTDSERENEWKWLDGTSPDYKNWKAGQPDNWGHGHGPGEDCAGLIYAGQWNDFQCEDVNNFICEKDRETVLSSAL
uniprot
proteins
function
FUNCTION: Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Also binds to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:15845541, ECO:0000269|PubMed:16868960}.
uniprot
proteins
mass_dalton
81515
uniprot
proteins
pubmed
11162630
uniprot
proteins
pubmed
11564734
uniprot
proteins
pubmed
12601552
uniprot
proteins
pubmed
12761161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15845541
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
16868960
uniprot
proteins
pubmed
17420244
uniprot
proteins
pubmed
17974005
uniprot
proteins
sequence_length
742
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11162630}; Single-pass type II membrane protein {ECO:0000269|PubMed:11162630}. Note=Forms clusters on the cell surface.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins