Spcs3
entrez
76687
canonical
uniprot
Q6ZWQ7
canonical
ensembl
ENSMUSG00000054408
resolver
ensp
ENSMUSP00000136527
resolver
enst
ENSMUST00000067476
resolver
genesymbol
Spcs3
resolver
uniprot
Q8C1D0
resolver
uniprot_entry
SPCS3_MOUSE
resolver
uniprot_sec
Q8C1D0
resolver
amino_acid_sequence
MNTVLSRANSLFAFSLSVMAALTFGCFITTAFKDRSVPVRLHVSRIMLKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKDMKTKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLVTGSGHVSVPFPDTYEITKSY
uniprot
proteins
function
FUNCTION: Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity). {ECO:0000250|UniProtKB:P61009, ECO:0000250|UniProtKB:Q12133}.
uniprot
proteins
mass_dalton
20313
uniprot
proteins
protein_family
SPCS3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
180
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P61008}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P61008}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins