Tnk1
entrez
83813
canonical
uniprot
Q99ML2
canonical
ensembl
ENSMUSG00000001583
resolver
ensp
ENSMUSP00000001626
resolver
ensp
ENSMUSP00000331987
resolver
genesymbol
Tnk1
resolver
genesymbol_syn
Kos1
resolver
uniprot
Q3TJU8
resolver
uniprot
Q8CCC4
resolver
uniprot
Q8K0X9
resolver
uniprot
Q91V11
resolver
uniprot_entry
Q3TJU8_MOUSE
resolver
uniprot_entry
TNK1_MOUSE
resolver
uniprot_sec
Q8CCC4
resolver
uniprot_sec
Q8K0X9
resolver
uniprot_sec
Q91V11
resolver
amino_acid_sequence
MLPEASSLWLLRLLRDVQLAQFYRPILEELNVTRPEHFDFVRPEDLDNIGMGRPAQRRLNEALKRYRSGVKSKNWVYKILGGFAPEQKEIPPRSDSPLCFHEPEGGLKCLIPEGAVRRGELLGSGCFGVVHRGLWTLPSGQSIPVAVKSLRVGPEGPMGTELGDFLREVSVMMKLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLPVALLCLFLRQLAGAMAYLGSCGLVHRDLATRNLLLASPRMIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRQGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEKDRARLPKPPLCSRALYSLALRCWAPHPADRPSFSNLEGLLQEAWLSEGRCVREVTEPGALRMEPGDPITIIEGSLDTATWKGQNGRTLKVGNFPASAVTLADLGGSPVTHPAHRGSPAHGEKCRGGTDGDREKATLQDLPPARSHRTKMPLQRMRGISKSLESVLSLGPRPTGGGSSPPELRRTRAMPQRLPDLPPRPPDLPPRPPIICNSSQPTQPHKARPKRESSHNHRTGAPGASKATVPSGGPLSDPEWQRKVVEVELSVHGVTYQECQVALRTTGGDVASAIRNLKVDQLFHLSNRSRADCRRILEHHQWDLSAASRYILARS
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction (By similarity). Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. {ECO:0000250, ECO:0000269|PubMed:12789265, ECO:0000269|PubMed:18974114}.
uniprot
proteins
mass_dalton
73099
uniprot
proteins
mutagenesis
MUTAGEN 148; /note="K->A: Loss of autophosphorylation."; /evidence="ECO:0000269|PubMed:12789265
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on tyrosine residues. {ECO:0000269|PubMed:12789265}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
12789265
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18974114
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
666
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:12789265}.
uniprot
proteins