NOSIP
entrez
51070
canonical
uniprot
Q9Y314
canonical
ensembl
ENSG00000142546
resolver
ensp
ENSP00000343497
resolver
ensp
ENSP00000470034
resolver
ensp
ENSP00000544221
resolver
ensp
ENSP00000544222
resolver
ensp
ENSP00000544223
resolver
ensp
ENSP00000544224
resolver
ensp
ENSP00000544225
resolver
ensp
ENSP00000544226
resolver
ensp
ENSP00000544228
resolver
ensp
ENSP00000544229
resolver
ensp
ENSP00000544230
resolver
ensp
ENSP00000544231
resolver
ensp
ENSP00000544232
resolver
ensp
ENSP00000544233
resolver
ensp
ENSP00000587132
resolver
ensp
ENSP00000587133
resolver
ensp
ENSP00000587134
resolver
ensp
ENSP00000587135
resolver
ensp
ENSP00000587136
resolver
ensp
ENSP00000632243
resolver
ensp
ENSP00000632244
resolver
enst
ENST00000339093
resolver
enst
ENST00000596358
resolver
enst
ENST00000874162
resolver
enst
ENST00000874163
resolver
enst
ENST00000874164
resolver
enst
ENST00000874165
resolver
enst
ENST00000874166
resolver
enst
ENST00000874167
resolver
enst
ENST00000874169
resolver
enst
ENST00000874170
resolver
enst
ENST00000874171
resolver
enst
ENST00000874172
resolver
enst
ENST00000874173
resolver
enst
ENST00000874174
resolver
enst
ENST00000917073
resolver
enst
ENST00000917074
resolver
enst
ENST00000917075
resolver
enst
ENST00000917076
resolver
enst
ENST00000917077
resolver
enst
ENST00000962184
resolver
enst
ENST00000962185
resolver
genesymbol
NOSIP
resolver
hgnc
HGNC:17946
resolver
uniprot
A0A075B6F9
resolver
uniprot
Q96FD2
resolver
uniprot_entry
A0A075B6F9_HUMAN
resolver
uniprot_entry
NOSIP_HUMAN
resolver
uniprot_sec
Q96FD2
resolver
amino_acid_sequence
MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKKEIARQMKAYEKQRGTRREEQKELQRAASQDHVRGFLEKESAIVSRPLNPFTAKALSGTSPDDVQPGPSVGPPSKDKDKVLPSFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTPVHFTPLDSSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVTGDKLTDRDIIVLQRGGTGFAGSGVKLQAEKSRPVMQA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813). {ECO:0000250|UniProtKB:Q9D6T0, ECO:0000269|PubMed:11149895, ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}.
uniprot
proteins
mass_dalton
33172
uniprot
proteins
protein_family
NOSIP family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11149895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15548660
uniprot
proteins
pubmed
16135813
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
301
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}. Nucleus {ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle (PubMed:16135813).
uniprot
proteins