SLCO2A1
entrez
6578
canonical
uniprot
Q92959
canonical
ensembl
ENSG00000174640
resolver
ensp
ENSP00000311291
resolver
enst
ENST00000310926
resolver
genesymbol
SLCO2A1
resolver
genesymbol_syn
OATP2A1
resolver
genesymbol_syn
SLC21A2
resolver
hgnc
HGNC:10955
resolver
uniprot
Q86V98
resolver
uniprot
Q8IUN2
resolver
uniprot_entry
SO2A1_HUMAN
resolver
uniprot_sec
Q86V98
resolver
uniprot_sec
Q8IUN2
resolver
activity_regulation
ACTIVITY REGULATION: Chorionic gonadotropin stimulates expression in the ovaries. {ECO:0000269|PubMed:27169804}.
uniprot
proteins
amino_acid_sequence
MGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYNVQKAAGLI
uniprot
proteins
disease_involvement
DISEASE: PHOAR2-enteropathy syndrome (PHOAR2E) [MIM:614441]: An autosomal recessive disease characterized by primary hypertrophic osteoarthropathy and/or chronic non-specific ulcers of the small intestine. Affected individuals present with digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Chronic ulcers of the small intestine result in abdominal pain and watery diarrhea, and are associated with chronic anemia. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. {ECO:0000269|PubMed:22197487, ECO:0000269|PubMed:22331663, ECO:0000269|PubMed:22553128, ECO:0000269|PubMed:22696055, ECO:0000269|PubMed:23509104, ECO:0000269|PubMed:33852188}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Hypertrophic osteoarthropathy, primary, autosomal dominant (PHOAD) [MIM:167100]: A form of primary hypertrophic osteoarthropathy, a disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. PHOAD patients may also experience joint swelling and pain, and some have reported gastrointestinal symptoms, including watery diarrhea. Males are more commonly affected, and more severely affected, than females. {ECO:0000269|PubMed:23509104, ECO:0000269|PubMed:33852188}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Mediates the transport of prostaglandins (PGs, mainly PGE2, PGE1, PGE3, PGF2alpha, PGD2, PGH2) and thromboxanes (thromboxane B2) across the cell membrane (PubMed:11997326, PubMed:26692285, PubMed:8787677). PGs and thromboxanes play fundamental roles in diverse functions such as intraocular pressure, gastric acid secretion, renal salt and water transport, vascular tone, and fever (PubMed:15044627). Plays a role in the clearance of PGs from the circulation through cellular uptake, which allows cytoplasmic oxidation and PG signal termination (PubMed:8787677). PG uptake is dependent upon membrane potential and involves exchange of a monovalent anionic substrate (PGs exist physiologically as an anionic monovalent form) with a stoichiometry of 1:1 for divalent anions or of 1:2 for monovalent anions (PubMed:29204966). Uses lactate, generated by glycolysis, as a counter-substrate to mediate PGE2 influx and efflux (PubMed:11997326). Under nonglycolytic conditions, metabolites other than lactate might serve as counter-substrates (PubMed:11997326). Although the mechanism is not clear, this transporter can function in bidirectional mode (PubMed:29204966). When apically expressed in epithelial cells, it facilitates transcellular transport (also called vectorial release), extracting PG from the apical medium and facilitating transport across the cell toward the basolateral side, whereupon the PG exits the cell by simple diffusion (By similarity). In the renal collecting duct, regulates renal Na+ balance by removing PGE2 from apical medium (PGE2 EP4 receptor is likely localized to the luminal/apical membrane and stimulates Na+ resorption) and transporting it toward the basolateral membrane (where PGE2 EP1 and EP3 receptors inhibit Na+ resorption) (By similarity). Plays a role in endometrium during decidualization, increasing uptake of PGs by decidual cells (PubMed:16339169). Involved in critical events for ovulation (PubMed:27169804). Regulates extracellular PGE2 concentration for follicular development in the ovaries (By similarity). Expressed intracellularly, may contribute to vesicular uptake of newly synthesized intracellular PGs, thereby facilitating exocytotic secretion of PGs without being metabolized (By similarity). Essential core component of the major type of large-conductance anion channel, Maxi-Cl, which plays essential roles in inorganic anion transport, cell volume regulation and release of ATP and glutamate not only in physiological processes but also in pathological processes (By similarity). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). {ECO:0000250|UniProtKB:Q00910, ECO:0000250|UniProtKB:Q9EPT5, ECO:0000269|PubMed:11997326, ECO:0000269|PubMed:16339169, ECO:0000269|PubMed:26692285, ECO:0000269|PubMed:27169804, ECO:0000269|PubMed:8787677, ECO:0000303|PubMed:11997326, ECO:0000303|PubMed:15044627, ECO:0000303|PubMed:29204966, ECO:0000305|PubMed:35307651}.
uniprot
proteins
mass_dalton
70044
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
10484490
uniprot
proteins
pubmed
11997326
uniprot
proteins
pubmed
15044627
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15657371
uniprot
proteins
pubmed
16339169
uniprot
proteins
pubmed
22197487
uniprot
proteins
pubmed
22331663
uniprot
proteins
pubmed
22553128
uniprot
proteins
pubmed
22696055
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23509104
uniprot
proteins
pubmed
26692285
uniprot
proteins
pubmed
27169804
uniprot
proteins
pubmed
29204966
uniprot
proteins
pubmed
33852188
uniprot
proteins
pubmed
35307651
uniprot
proteins
pubmed
8787677
uniprot
proteins
pubmed
9618293
uniprot
proteins
sequence_length
643
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:8787677}; Multi-pass membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9EPT5}. Lysosome {ECO:0000250|UniProtKB:Q9EPT5}. Note=Localized to the basal membrane of Sertoli cells. {ECO:0000269|PubMed:35307651}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..52; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 72..92; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 99..123; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 168..196; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 216..236; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 255..279; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 322..343; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 364..387; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 392..415; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 519..541; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 551..576; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 611..629; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins