Mapk8ip3
entrez
30957
canonical
uniprot
Q9ESN9
canonical
ensembl
ENSMUSG00000024163
resolver
ensp
ENSMUSP00000085683
resolver
ensp
ENSMUSP00000110883
resolver
ensp
ENSMUSP00000112712
resolver
ensp
ENSMUSP00000112955
resolver
ensp
ENSMUSP00000113698
resolver
ensp
ENSMUSP00000113753
resolver
ensp
ENSMUSP00000114084
resolver
enst
ENSMUST00000121723
resolver
enst
ENSMUST00000121787
resolver
genesymbol
Mapk8ip3
resolver
genesymbol_syn
Jip3
resolver
genesymbol_syn
Jsap1
resolver
genesymbol_syn
Syd2
resolver
uniprot
E9Q6B6
resolver
uniprot
E9Q6E0
resolver
uniprot
Q3UHB5
resolver
uniprot
Q3UYC3
resolver
uniprot
Q5D062
resolver
uniprot
Q6P1F1
resolver
uniprot
Q99KU7
resolver
uniprot
Q9EQD8
resolver
uniprot
Q9ESN7
resolver
uniprot
Q9ESN8
resolver
uniprot
Q9ESP0
resolver
uniprot
Q9JLH2
resolver
uniprot
Q9JLH3
resolver
uniprot
Q9R0U7
resolver
uniprot_entry
E9Q6B6_MOUSE
resolver
uniprot_entry
E9Q6E0_MOUSE
resolver
uniprot_entry
JIP3_MOUSE
resolver
uniprot_entry
Q3UHB5_MOUSE
resolver
uniprot_entry
Q3UYC3_MOUSE
resolver
uniprot_entry
Q6P1F1_MOUSE
resolver
uniprot_sec
Q5D062
resolver
uniprot_sec
Q99KU7
resolver
uniprot_sec
Q9EQD8
resolver
uniprot_sec
Q9ESN7
resolver
uniprot_sec
Q9ESN8
resolver
uniprot_sec
Q9ESP0
resolver
uniprot_sec
Q9JLH2
resolver
uniprot_sec
Q9JLH3
resolver
uniprot_sec
Q9R0U7
resolver
amino_acid_sequence
MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRKQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGSGQTESSLPGRSRKERPTSLNVFPLADGMVRAQMGGKLVPAGDHWHLSDLGQLQSSSSYQCPNDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYVSVTKNNKQAREKRNSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDVCPETRLERTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLKGELEAAKQAKVKLENRIKELEEELKRVKSEAVTARREPREEVEDVSSYLCTELDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRSYPSVNIHYKSPTAAGFSQRRSHALCQISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGRLQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPSTKLWCAAGVNLSGWKPHEEDSSNGPKPVPGRDPLTCDREGEGEPKSTHPSPEKKKAKETPEADATSSRVWILTSTLTTSKVVIIDANQPGTIVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDSGADGVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGDVATTANGKVNPSQSTEEATEATEVPDPGPSESEATTVRPGPLTEHVFTDPAPTPSSSTQPASENGSESNGTIVQPQVEPSGELSTTTSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVNDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITALLIAGNRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGTRPGGIIHVYGDDSSDKAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSPSEGPGPAAPAADAEGQKLKNALVLSGGEGYIDFRIGDGEDDETEECAGDVNQTKPSLSKAERSHIIVWQVSYTPE
uniprot
proteins
function
FUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (PubMed:10523642, PubMed:10629060). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner (PubMed:23576431, PubMed:25944905, PubMed:28259553). Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation (PubMed:23576431, PubMed:25944905, PubMed:28259553). Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration (PubMed:23576431, PubMed:25944905, PubMed:28259553). Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (PubMed:23576431, PubMed:25944905, PubMed:28259553). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:23576431, PubMed:25944905, PubMed:28259553). {ECO:0000269|PubMed:10523642, ECO:0000269|PubMed:10629060, ECO:0000269|PubMed:23576431, ECO:0000269|PubMed:25944905, ECO:0000269|PubMed:28259553}.
uniprot
proteins
mass_dalton
147561
uniprot
proteins
mutagenesis
MUTAGEN 205; /note="R->G: Results in inhibition of JNK binding."; /evidence="ECO:0000269|PubMed:10629060"; MUTAGEN 206; /note="P->G: Results in inhibition of JNK binding."; /evidence="ECO:0000269|PubMed:10629060"; MUTAGEN 207; /note="T->G: Results in inhibition of JNK binding."; /evidence="ECO:0000269|PubMed:10629060"; MUTAGEN 208; /note="S->G: Results in inhibition of JNK binding."; /evidence="ECO:0000269|PubMed:10629060"; MUTAGEN 209; /note="L->G: Results in inhibition of JNK binding."; /evidence="ECO:0000269|PubMed:10629060"; MUTAGEN 266; /note="T->A: Results in loss of phosphorylation of MAPK8IP3; when associated with A-276 and A-287. Does not effect binding of components of the JNK pathway."; /evidence="ECO:0000269|PubMed:10629060"; MUTAGEN 276; /note="T->A: Results in loss of phosphorylation of MAPK8IP3; when associated with A-266 and A-287. Does not effect binding of components of the JNK pathway."; /evidence="ECO:0000269|PubMed:10629060"; MUTAGEN 287; /note="T->A: Results in loss of phosphorylation of MAPK8IP3; when associated with A-266 and A-287. Does not effect binding of components of the JNK pathway."; /evidence="ECO:0000269|PubMed:10629060
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by ROCK1 is crucial for the recruitment of JNK. {ECO:0000250|UniProtKB:Q9UPT6}.
uniprot
proteins
protein_family
JIP scaffold family
uniprot
proteins
pubmed
10523642
uniprot
proteins
pubmed
10629060
uniprot
proteins
pubmed
11024282
uniprot
proteins
pubmed
11106729
uniprot
proteins
pubmed
11238452
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21775604
uniprot
proteins
pubmed
23576431
uniprot
proteins
pubmed
25944905
uniprot
proteins
pubmed
28259553
uniprot
proteins
sequence_length
1337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10629060}. Golgi apparatus {ECO:0000269|PubMed:11106729}. Cytoplasmic vesicle {ECO:0000269|PubMed:11106729}. Cell projection, growth cone {ECO:0000269|PubMed:10629060}. Cell projection, axon {ECO:0000269|PubMed:25944905}. Cell projection, dendrite {ECO:0000250|UniProtKB:E9PSK7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:E9PSK7}. Note=Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells (PubMed:10629060, PubMed:11106729). KIF5A/B/C-mediated transportation to axon tips is essential for its function in enhancing neuronal axon elongation (By similarity). {ECO:0000250|UniProtKB:E9PSK7, ECO:0000269|PubMed:10629060, ECO:0000269|PubMed:11106729}.
uniprot
proteins