Pde1c
entrez
81742
canonical
uniprot
Q63421
canonical
ensembl
ENSRNOG00000012337
resolver
ensp
ENSRNOP00000017531
resolver
ensp
ENSRNOP00000077659
resolver
ensp
ENSRNOP00000089783
resolver
ensp
ENSRNOP00000096395
resolver
ensp
ENSRNOP00000099194
resolver
ensp
ENSRNOP00000099233
resolver
enst
ENSRNOT00000017531
resolver
enst
ENSRNOT00000118567
resolver
enst
ENSRNOT00000146532
resolver
genesymbol
Pde1c
resolver
genesymbol_syn
Pde1c2
resolver
uniprot
A0A8I6A8V6
resolver
uniprot
A0ABK0L4E5
resolver
uniprot
F1LMX4
resolver
uniprot_entry
A0A8I6A8V6_RAT
resolver
uniprot_entry
A0ABK0L4E5_RAT
resolver
uniprot_entry
F1LMX4_RAT
resolver
uniprot_entry
PDE1C_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+). {ECO:0000269|PubMed:7568196}.
uniprot
proteins
amino_acid_sequence
MTDTSHKKEGFKKCRSATFSIDGYSFTIVANEAGDKNARPLARFSRSKSQNCLWNSLIDGLTGNVKEKPRPTIVQDTRPPEEILADELPQLDSPEALVKTSFRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIDALKDVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSINSSDAKRSGVKSSGSEGSAPINNSVIPVDYKSFKATWTEVVQINRERWRAKVPKEEKAKKEAEEKARLAAEEKQKEMEAKSQAEQGTTSKAEKKTSGETKGQVNGTRTSKGDNPRGKNSKGDKAGEKQQNGDLKDGKNKADKKDHSNTGNESKKADGTKKRSHGSPAPSTSSTSRLTLPVIKPPLRHFKRPAYASSSYAPSVPKKTDDHPVRYKMLDQRIKIKKIQNISHHWNKK
uniprot
proteins
ec_number
3.1.4.17
uniprot
proteins
function
FUNCTION: Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP (PubMed:7568196). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (By similarity). In kidney juxtaglomerular granular cells, inhibits renin release by decreasing cAMP levels (PubMed:19741056). {ECO:0000250|UniProtKB:Q14123, ECO:0000269|PubMed:19741056, ECO:0000269|PubMed:7568196}.
uniprot
proteins
mass_dalton
86671
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE1 subfamily
uniprot
proteins
pubmed
19741056
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7568196
uniprot
proteins
sequence_length
768
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q64338}.
uniprot
proteins