Nek11
entrez
208583
canonical
uniprot
Q8C0Q4
canonical
ensembl
ENSMUSG00000035032
resolver
ensp
ENSMUSP00000038611
resolver
ensp
ENSMUSP00000116864
resolver
enst
ENSMUST00000038648
resolver
genesymbol
Nek11
resolver
uniprot
E9QNC3
resolver
uniprot
Q8BLS6
resolver
uniprot
Q8BW62
resolver
uniprot_entry
NEK11_MOUSE
resolver
uniprot_sec
E9QNC3
resolver
uniprot_sec
Q8BLS6
resolver
uniprot_sec
Q8BW62
resolver
activity_regulation
ACTIVITY REGULATION: Autorepressed by intramolecular binding of the C-terminus which dissociates following phosphorylation by NEK2. Activated in response to DNA damage. Inhibited by zinc. {ECO:0000250|UniProtKB:Q8NG66}.
uniprot
proteins
amino_acid_sequence
MLKFQETAKCVGRRPTVIPMYPTALIARRYVLQQKLGSGSFGTVYLVSDKKAKPGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQETFCIITEYCEGRDLDYRIQEYKEAGKVFAENQIVEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSRLLMGSCELATTLTGTPHYMSPEALKHQGYDAKSDIWSLACILYEMCCLDHAFAGSSFLSVVLNIVEGKTPSLPDRYPRELNTIMERMLNKSPSLRPSAADILKAPYMEEQLQLLMCKYPEMTLEDKNSVCQKEAAHTINAVQKKLHLQTLQALSDTQKTTPRERMWLRKLQAADERARRLKKIAEENYKENDKRMQALRSRNVGSVHAHVLHELDERTLESLPEPQSLPCLDLDELEPSLEDTIVDLGHYEIPEDPLVAEQYYSDVFDSCSEDSEEQEEEMIFSEAGGDTKEEESPSVYRTNQQDSDTAALVGCLEHVLGYTSLDTKTITNAVTDMSPGPMVFNSAVARTKMKRMKESAVQKLGMETFEEVYDYLKRARHQNAREAEIWEHLETVVPRASDCFEVDQLLYFEELLLTMEGKEPSLQNLPCEAAQKKPVKGTHFCDNP
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000250|UniProtKB:Q8NG66}.
uniprot
proteins
mass_dalton
71648
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NEK2. Phosphorylation at Ser-274 is important for its activation. {ECO:0000250|UniProtKB:Q8NG66}.
uniprot
proteins
protein_family
NEK Ser/Thr protein kinase family
uniprot
proteins
protein_family
NIMA subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
628
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8NG66}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8NG66}. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S-arrested cells. {ECO:0000250|UniProtKB:Q8NG66}.
uniprot
proteins