Il11ra1
entrez
16157
canonical
uniprot
Q64385
canonical
ensembl
ENSMUSG00000073889
resolver
ensp
ENSMUSP00000095736
resolver
ensp
ENSMUSP00000103675
resolver
ensp
ENSMUSP00000103676
resolver
ensp
ENSMUSP00000103677
resolver
enst
ENSMUST00000098132
resolver
enst
ENSMUST00000108040
resolver
enst
ENSMUST00000108041
resolver
enst
ENSMUST00000108042
resolver
genesymbol
Il11ra1
resolver
genesymbol_syn
Etl2
resolver
genesymbol_syn
Il11ra
resolver
uniprot
A2AMS4
resolver
uniprot
Q3UIV4
resolver
uniprot
Q6NSQ0
resolver
uniprot_entry
I11RA_MOUSE
resolver
uniprot_entry
Q3UIV4_MOUSE
resolver
uniprot_sec
A2AMS4
resolver
uniprot_sec
Q6NSQ0
resolver
amino_acid_sequence
MSSSCSGLTRVLVAVATALVSSSSPCPQAWGPPGVQYGQPGRPVMLCCPGVSAGTPVSWFRDGDSRLLQGPDSGLGHRLVLAQVDSPDEGTYVCQTLDGVSGGMVTLKLGFPPARPEVSCQAVDYENFSCTWSPGQVSGLPTRYLTSYRKKTLPGAESQRESPSTGPWPCPQDPLEASRCVVHGAEFWSEYRINVTEVNPLGASTCLLDVRLQSILRPDPPQGLRVESVPGYPRRLHASWTYPASWRRQPHFLLKFRLQYRPAQHPAWSTVEPIGLEEVITDAVAGLPHAVRVSARDFLDAGTWSAWSPEAWGTPSTGPLQDEIPDWSQGHGQQLEAVVAQEDSPAPARPSLQPDPRPLDHRDPLEQVAVLASLGIFSCLGLAVGALALGLWLRLRRSGKDGPQKPGLLAPMIPVEKLPGIPNLQRTPENFS
uniprot
proteins
function
FUNCTION: Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth.; FUNCTION: [Soluble interleukin-11 receptor subunit alpha]: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling. {ECO:0000250|UniProtKB:Q14626}.
uniprot
proteins
mass_dalton
46655
uniprot
proteins
post_translational_modification
PTM: A short soluble form is also released from the membrane by proteolysis (PubMed:26876177). The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing (PubMed:26876177). mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3 (PubMed:26876177). {ECO:0000269|PubMed:26876177}.
uniprot
proteins
protein_family
Type 3 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21741611
uniprot
proteins
pubmed
26876177
uniprot
proteins
pubmed
7813775
uniprot
proteins
pubmed
7957045
uniprot
proteins
pubmed
8662802
uniprot
proteins
pubmed
8973540
uniprot
proteins
pubmed
9373251
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Interleukin-11 receptor subunit alpha-1]: Membrane {ECO:0000269|PubMed:26876177}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:Q14626}.; SUBCELLULAR LOCATION: [Soluble interleukin-11 receptor subunit alpha]: Secreted {ECO:0000269|PubMed:26876177}.
uniprot
proteins
transmembrane_region
TRANSMEM 373..393; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins