Timp3
entrez
21859
canonical
uniprot
P39876
canonical
ensembl
ENSMUSG00000020044
resolver
ensp
ENSMUSP00000020234
resolver
enst
ENSMUST00000020234
resolver
genesymbol
Timp3
resolver
genesymbol_syn
Sun
resolver
genesymbol_syn
Timp-3
resolver
uniprot
Q54AE5
resolver
uniprot
Q91WL9
resolver
uniprot_entry
Q54AE5_MOUSE
resolver
uniprot_entry
TIMP3_MOUSE
resolver
uniprot_sec
Q91WL9
resolver
amino_acid_sequence
MTPWLGLVVLLSCWSLGHWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVKEGPFGTLVYTIKQMKMYRGFSKMPHVQYIHTEASESLCGLKLEVNKYQYLLTGRVYEGKMYTGLCNFVERWDHLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDMLSNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSISNATDP
uniprot
proteins
function
FUNCTION: Mediates a variety of processes including matrix regulation and turnover, inflammation, and angiogenesis, through reversible inhibition of zinc protease superfamily enzymes, primarily matrix metalloproteinases (MMPs) (PubMed:15322543, PubMed:21282576). Regulates extracellular matrix (ECM) remodeling through inhibition of matrix metalloproteinases (MMP) including MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Additionally, modulates the processing of amyloid precursor protein (APP) and apolipoprotein E receptor ApoER2 by inhibiting two alpha-secretases ADAM10 and ADAM17. Functions as a tumor suppressor and a potent inhibitor of angiogenesis. Exerts its anti-angiogenic effect by directly interacting with vascular endothelial growth factor (VEGF) receptor-2/KDR, preventing its binding to the VEGFA ligand. Selectively induces apoptosis in angiogenic endothelial cells through a caspase-independent cell death pathway. Mechanistically, inhibits matrix-induced focal adhesion kinase PTK2 tyrosine phosphorylation and association with paxillin/PXN and disrupts the incorporation of ITGB3, PTK2 and PXN into focal adhesion contacts on the matrix. {ECO:0000250|UniProtKB:P35625, ECO:0000269|PubMed:15322543, ECO:0000269|PubMed:21282576}.
uniprot
proteins
mass_dalton
24182
uniprot
proteins
protein_family
Protease inhibitor I35 (TIMP) family
uniprot
proteins
pubmed
15322543
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21282576
uniprot
proteins
pubmed
7642607
uniprot
proteins
pubmed
7782289
uniprot
proteins
pubmed
7949367
uniprot
proteins
pubmed
8118794
uniprot
proteins
pubmed
8132674
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P35625}.
uniprot
proteins