Catsper1
entrez
225865
canonical
uniprot
Q91ZR5
canonical
ensembl
ENSMUSG00000038498
resolver
ensp
ENSMUSP00000045430
resolver
ensp
ENSMUSP00000157759
resolver
enst
ENSMUST00000043380
resolver
genesymbol
Catsper1
resolver
uniprot
Q4PZC3
resolver
uniprot
Q4PZC4
resolver
uniprot
Q4PZC5
resolver
uniprot
Q4PZC6
resolver
uniprot
Q4PZD2
resolver
uniprot_entry
CTSR1_MOUSE
resolver
uniprot_sec
Q4PZC3
resolver
uniprot_sec
Q4PZC4
resolver
uniprot_sec
Q4PZC5
resolver
uniprot_sec
Q4PZC6
resolver
uniprot_sec
Q4PZD2
resolver
activity_regulation
ACTIVITY REGULATION: Activated by intracellular alkalinization (By similarity). In contrast to the human ortholog, not activated by progesterone (PubMed:21412339). {ECO:0000250|UniProtKB:Q8NEC5, ECO:0000269|PubMed:21412339}.
uniprot
proteins
amino_acid_sequence
MDQSSRRDESYHETHPGSLDPSHQSHPHPHPHPTLHRPNQGGVYYDSPQHGMFQQPYQQHGGFHQQNELQHLREFSDSHDNAFSHHSYQQDRAGVSTLPNNISHAYGGSHPLAESQHSGGPQSGPRIDPNHHPHQDDPHRPSEPLSHPSSTGSHQGTTHQQYHERSHHLNPQQNRDHADTISYRSSTRFYRSHAPFSRQERPHLHADHHHEGHHAHSHHGEHPHHKEQRHYHGDHMHHHIHHRSPSASQLSHKSHSTLATSPSHVGSKSTASGARYTFGARSQIFGKAQSRESLRESASLSEGEDHVQKRKKAQRAHKKAHTGNIFQLLWEKISHLLLGLQQMILSLTQSLGFETFIFIVVCLNTVILVAQTFTELEIRGEWYFMVLDSIFLSIYVLEAVLKLIALGLEYFYDPWNNLDFFIMVMAVLDFVLLQINSLSYSFYNHSLFRILKVFKSMRALRAIRVLRRLSILTSLHEVAGTLSGSLPSITAILTLMFTCLFLFSVVLRALFQDSDPKRFQNIFTTLFTLFTMLTLDDWSLIYIDNRAQGAWYIIPILMIYIVIQYFIFLNLVIAVLVDNFQMALLKGLEKVKLEQAARVHEKLLDDSLTDLNKADANAQMTEEALKMQLIEGMFGNMTVKQRVLHFQFLQLVAAVEQHQQKFRSQAYVIDELVDMAFEAGDDDYGK
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. {ECO:0000269|PubMed:11595941, ECO:0000269|PubMed:14657352, ECO:0000269|PubMed:16036917, ECO:0000269|PubMed:16467839, ECO:0000269|PubMed:17174296}.
uniprot
proteins
mass_dalton
78706
uniprot
proteins
protein_family
Cation channel sperm-associated (TC 1.A.1.19) family
uniprot
proteins
pubmed
11595941
uniprot
proteins
pubmed
14657352
uniprot
proteins
pubmed
14688170
uniprot
proteins
pubmed
15930155
uniprot
proteins
pubmed
16036917
uniprot
proteins
pubmed
16467839
uniprot
proteins
pubmed
17174296
uniprot
proteins
pubmed
17227845
uniprot
proteins
pubmed
17347248
uniprot
proteins
pubmed
17478420
uniprot
proteins
pubmed
19516020
uniprot
proteins
pubmed
21224844
uniprot
proteins
pubmed
21412339
uniprot
proteins
pubmed
34225353
uniprot
proteins
pubmed
34998468
uniprot
proteins
sequence_length
686
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:11595941, ECO:0000269|PubMed:34998468}; Multi-pass membrane protein {ECO:0000269|PubMed:34225353}. Note=Specifically located in the principal piece of the sperm tail. {ECO:0000269|PubMed:34225353, ECO:0000269|PubMed:34998468}.
uniprot
proteins
transmembrane_region
TRANSMEM 352..373; /note="Helical; Name=Segment S1"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 383..404; /note="Helical; Name=Segment S2"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 413..435; /note="Helical; Name=Segment S3"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 447..469; /note="Helical; Name=Segment S4"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 488..510; /note="Helical; Name=Segment S5"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 552..577; /note="Helical; Name=Segment S6"; /evidence="ECO:0000269|PubMed:34225353
uniprot
proteins