Tm4sf19
entrez
277203
canonical
uniprot
E9Q9H8
canonical
ensembl
ENSMUSG00000079625
resolver
ensp
ENSMUSP00000110802
resolver
enst
ENSMUST00000115149
resolver
genesymbol
Tm4sf19
resolver
uniprot
B2RWD4
resolver
uniprot_entry
T4S19_MOUSE
resolver
uniprot_sec
B2RWD4
resolver
amino_acid_sequence
MLSFSRVVNCSRTCSRFLGLSLGTASLCAAGANIALLFPNWDVTYLMRGLIGKHAMLGSGLWGGGLMVLLAATLISMTGSFSKSAPCLQVLIALLSSGLALLGAVICFVTSGVALKDGPFCMFDVSSFNQTQAWKFGYPFKDLHNRNYLYDRSLWTSVCLEPSKAVVWHVAFFSILLCISLLQLLLVAIHLVNSILGLFCSFCEKH
uniprot
proteins
function
FUNCTION: Negatively regulates vacuolar (H+)-ATPase (V-ATPase) activity by interacting with members of V-ATPase V0 complex and hence inhibiting V1-V0 assembly (PubMed:38555350). Required for multinucleation during osteoclast differentiation (PubMed:38016540). {ECO:0000269|PubMed:38016540, ECO:0000269|PubMed:38555350}.
uniprot
proteins
mass_dalton
22314
uniprot
proteins
protein_family
L6 tetraspanin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
38016540
uniprot
proteins
pubmed
38555350
uniprot
proteins
sequence_length
206
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:38555350}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:38016540}. Cell projection, filopodium {ECO:0000269|PubMed:38016540}. Note=In osteoclasts, localizes not only to the actin ring, but also to the filopodia, the stretched structures for searching cells to fuse, and the fusopod, the cytoplasmic bridge for contacting other osteoclasts to fuse. {ECO:0000269|PubMed:38016540}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 55..75; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins