PRRG2
entrez
5639
canonical
uniprot
O14669
canonical
ensembl
ENSG00000126460
resolver
ensp
ENSP00000246794
resolver
ensp
ENSP00000544420
resolver
ensp
ENSP00000544421
resolver
ensp
ENSP00000544422
resolver
ensp
ENSP00000544426
resolver
ensp
ENSP00000637697
resolver
enst
ENST00000246794
resolver
enst
ENST00000874361
resolver
enst
ENST00000874362
resolver
enst
ENST00000874363
resolver
enst
ENST00000874367
resolver
enst
ENST00000967638
resolver
genesymbol
PRRG2
resolver
genesymbol_syn
PRGP2
resolver
genesymbol_syn
TMG2
resolver
hgnc
HGNC:9470
resolver
uniprot
Q6IBF8
resolver
uniprot
Q8TAS3
resolver
uniprot_entry
Q8TAS3_HUMAN
resolver
uniprot_entry
TMG2_HUMAN
resolver
uniprot_sec
Q6IBF8
resolver
amino_acid_sequence
MRGHPSLLLLYMALTTCLDTSPSEETDQEVFLGPPEAQSFLSSHTRIPRANHWDLELLTPGNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGKGGRGRVDVASLAVGLTGGILLIVLAGLGAFWYLRWRQHRGQQPCPQEAGLISPLSPLNPLGPPTPLPPPPPPPPGLPTYEQALAASGVHDAPPPPYTSLRRPH
uniprot
proteins
function
FUNCTION: Vitamin K-dependent protein that is essential for calcium homeostasis and haemostasis. {ECO:0000269|PubMed:39880037}.
uniprot
proteins
mass_dalton
22393
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="F->A: Abolishes gamma-carboxylation."; /evidence="ECO:0000269|PubMed:17502622"; MUTAGEN 49; /note="R->A: Impairs propeptide removal."; /evidence="ECO:0000269|PubMed:17502622"; MUTAGEN 173; /note="P->A: No effect on interaction with YAP1."; /evidence="ECO:0000269|PubMed:17502622"; MUTAGEN 174; /note="G->A: No effect on interaction with YAP1."; /evidence="ECO:0000269|PubMed:17502622"; MUTAGEN 175; /note="L->A: Abolishes interaction with YAP1."; /evidence="ECO:0000269|PubMed:17502622"; MUTAGEN 176; /note="P->A: Abolishes interaction with YAP1."; /evidence="ECO:0000269|PubMed:17502622"; MUTAGEN 177; /note="T->A: Abolishes interaction with YAP1."; /evidence="ECO:0000269|PubMed:17502622"; MUTAGEN 178; /note="Y->A: Abolishes interaction with YAP1."; /evidence="ECO:0000269|PubMed:17502622"; MUTAGEN 179; /note="E->A: Significantly impairs interaction with YAP1."; /evidence="ECO:0000269|PubMed:17502622"; MUTAGEN 180; /note="Q->A: Significantly impairs interaction with YAP1."; /evidence="ECO:0000269|PubMed:17502622"; MUTAGEN 195; /note="Y->A: Significantly impairs interaction with YAP1."; /evidence="ECO:0000269|PubMed:17502622
uniprot
proteins
post_translational_modification
PTM: Carboxylated by vitamin K-dependent GGCX to form gamma-carboxyglutamate; these residues are essential for the binding of calcium (PubMed:17502622, PubMed:39880037). {ECO:0000269|PubMed:17502622, ECO:0000269|PubMed:39880037}.
uniprot
proteins
pubmed
17502622
uniprot
proteins
pubmed
23873930
uniprot
proteins
pubmed
39880037
uniprot
proteins
pubmed
9256434
uniprot
proteins
sequence_length
202
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17502622}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins