Slc22a13
entrez
102570
canonical
uniprot
Q6A4L0
canonical
ensembl
ENSMUSG00000074028
resolver
ensp
ENSMUSP00000081855
resolver
enst
ENSMUST00000084797
resolver
genesymbol
Slc22a13
resolver
genesymbol_syn
Orctl3
resolver
uniprot
E9QP74
resolver
uniprot
Q8VC89
resolver
uniprot_entry
S22AD_MOUSE
resolver
uniprot_sec
E9QP74
resolver
uniprot_sec
Q8VC89
resolver
amino_acid_sequence
MAQFAQVMAEVGDFGRFQVRLTILMGIPNFLAAFFIFGQVFMVLDEAHHCSVSWVKNHTFNLSAAEQLAISIPNDTAGRPESCLMFRPPPDSASLEDILSHRFNETQACDSGWDYPENRPQSLKKEFDLVCDRKNLKKTSQSVFMAGLLVGALVFGPVCDWIGRRPSLLMQVLLSGITSMATAFVSSFELYLALRFVLATANAGFLLSTNVLISEWVGPSWRTQAVVLAQSNVALGQMVLAGLAYGVRNWRLLQITGTAPVLLLFFYFWVLPESPRWLLSQGRTEEAKQLVQKAALVNGRPLSPELLNQLVPEKTGPSGNALDLFRHPHLRKVTLILIAVWFVDSLVYYSLSFQVGDFGLDIYVTQLIFGAVEMPGRFLSVLMMEKLGRKWSQLCTLTLAGIMYIIIIFIPGDLPTVVTVLAVVGKFASAAAFTISYVYTAELFPTIIRQTGMGLVSIFSRVGGIITPLVMLLEQYHQAIPMVIFGSLPIGAGLLCALLPETRGQTLKDTLQDLEQGLPAGSHKTAPQRQDMEALGRTSSVRVAVVKSSYF
uniprot
proteins
function
FUNCTION: Anion antiporter that mediates the transport of orotate and nicotinate in exchange for organic or inorganic anions (PubMed:35144162). Translocates orotate across the apical membrane of proximal tubule epithelial cells. Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption (PubMed:35144162). Orotate transport is Cl(-)-dependent (By similarity). {ECO:0000250|UniProtKB:Q9Y226, ECO:0000269|PubMed:35144162}.
uniprot
proteins
mass_dalton
60724
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q9Y226}.
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
35144162
uniprot
proteins
sequence_length
551
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9Y226}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Y226}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 252..272; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 333..353; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 355..375; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 405..425; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 428..448; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 453..473; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 479..499; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins