NUCB2
entrez
4925
canonical
uniprot
P80303
canonical
ensembl
ENSG00000070081
resolver
ensp
ENSP00000436455
resolver
ensp
ENSP00000579775
resolver
ensp
ENSP00000579778
resolver
ensp
ENSP00000579779
resolver
ensp
ENSP00000579780
resolver
ensp
ENSP00000579782
resolver
ensp
ENSP00000579785
resolver
ensp
ENSP00000579787
resolver
ensp
ENSP00000579804
resolver
ensp
ENSP00000579805
resolver
ensp
ENSP00000579807
resolver
ensp
ENSP00000620481
resolver
ensp
ENSP00000620483
resolver
ensp
ENSP00000620485
resolver
ensp
ENSP00000620496
resolver
ensp
ENSP00000660539
resolver
ensp
ENSP00000701214
resolver
ensp
ENSP00000701216
resolver
ensp
ENSP00000701220
resolver
ensp
ENSP00000788110
resolver
ensp
ENSP00000788111
resolver
ensp
ENSP00000788112
resolver
ensp
ENSP00000797104
resolver
ensp
ENSP00000797106
resolver
genesymbol
NUCB2
resolver
genesymbol
Nucb2
resolver
genesymbol_syn
NEFA
resolver
hgnc
HGNC:8044
resolver
uniprot
A8K642
resolver
uniprot
D3DQX5
resolver
uniprot
J3KQU0
resolver
uniprot
Q2L696
resolver
uniprot
Q8NFT5
resolver
uniprot
V9HW75
resolver
uniprot_entry
NUCB2_HUMAN
resolver
uniprot_entry
Q2L696_HUMAN
resolver
uniprot_sec
A8K642
resolver
uniprot_sec
D3DQX5
resolver
uniprot_sec
J3KQU0
resolver
uniprot_sec
Q8NFT5
resolver
uniprot_sec
V9HW75
resolver
amino_acid_sequence
MRWRTILLQYCFLLITCLLTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQGIPPSGPAGELKFEPHI
uniprot
proteins
function
FUNCTION: Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G protein) alpha subunit GNAI3 (By similarity). {ECO:0000250|UniProtKB:P81117, ECO:0000250|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740). {ECO:0000250|UniProtKB:Q9JI85, ECO:0000269|PubMed:39562740}.
uniprot
proteins
mass_dalton
50223
uniprot
proteins
protein_family
Nucleobindin family
uniprot
proteins
pubmed
11749975
uniprot
proteins
pubmed
12087473
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20427483
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30194280
uniprot
proteins
pubmed
39562740
uniprot
proteins
pubmed
7811391
uniprot
proteins
pubmed
9639681
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:11749975}. Membrane {ECO:0000269|PubMed:11749975}; Peripheral membrane protein {ECO:0000269|PubMed:11749975}. Cytoplasm {ECO:0000269|PubMed:11749975}. Secreted {ECO:0000269|PubMed:11749975}. Endoplasmic reticulum {ECO:0000250}. Nucleus envelope {ECO:0000250}. Note=Golgi retention is mediated by its N-terminal region.; SUBCELLULAR LOCATION: [Nesfatin-1]: Secreted.
uniprot
proteins