Habp4
entrez
361196
canonical
uniprot
A1L1K8
canonical
ensembl
ENSRNOG00000019027
resolver
ensembl
ENSRNOG00055024490
resolver
ensembl
ENSRNOG00060016168
resolver
ensembl
ENSRNOG00065023225
resolver
ensp
ENSRNOP00000025801
resolver
ensp
ENSRNOP00055034342
resolver
ensp
ENSRNOP00060022225
resolver
ensp
ENSRNOP00065032256
resolver
enst
ENSRNOT00000025801
resolver
enst
ENSRNOT00055042108
resolver
enst
ENSRNOT00060027668
resolver
enst
ENSRNOT00065039665
resolver
genesymbol
Habp4
resolver
uniprot_entry
HABP4_RAT
resolver
amino_acid_sequence
MKGALGSPVAAAGAAMQETFGCVVANRFHQLLDDESDPFDILREAEHRRQQQLQRKRRDEAAAASGAGHRGGRSPAVASGHRPGAAGRRESQKERKSLAVSSAQQPDSPGGPQPPGQKRTPRRGEQQGWNDNRGTDVVLDRAERRSYREYRPYDTERQAESTAEKFTDEKPVDRFDRDRPLRGRGGPRGGLRNRGRGGPGNRAFDSFDQRGKRDFERYGSSDKANRMEDSMGGCGVRTWGSGKDTSDTEPPAPMEETSMMEECQGVLDEESASKVPELEVEEENQVQEMTLDEWKNLQEQTRPKPEFNIRKPESTVPSKAVVIHKSRYRDDIVKDDYEDESHVFRKAANDITSQLEINFGNLPRPGRGARGSTRGGRGRIRRTENYGPRAEVVTQDVAPNPDDPEDFPALA
uniprot
proteins
function
FUNCTION: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature oocyte by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also binds RNA, regulating transcription and pre-mRNA splicing. Binds (via C-terminus) to poly(U) RNA. Seems to play a role in PML-nuclear bodies formation (By similarity). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (PubMed:15862299). {ECO:0000250|UniProtKB:Q5JVS0, ECO:0000250|UniProtKB:Q5XJA5, ECO:0000269|PubMed:15862299}.
uniprot
proteins
mass_dalton
45826
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-352 and Thr-373. {ECO:0000250|UniProtKB:Q5JVS0}.; PTM: Methylated. Methylation is decreased by phorbol 12-myristate 13-acetate (PMA)-activated PKC, in vitro. {ECO:0000250|UniProtKB:Q5JVS0}.
uniprot
proteins
protein_family
SERBP1-HABP4 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15862299
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15862299}. Cytoplasm {ECO:0000269|PubMed:15862299}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q5JVS0}. Cytoplasm, sarcoplasm {ECO:0000269|PubMed:15862299}. Nucleus, nuclear body {ECO:0000250|UniProtKB:Q5JVS0}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q5JVS0}. Nucleus speckle {ECO:0000250|UniProtKB:Q5JVS0}. Nucleus, Cajal body {ECO:0000250|UniProtKB:Q5JVS0}. Nucleus, gem {ECO:0000250|UniProtKB:Q5JVS0}. Note=Transported into the nuclear compartment in activated leukocytes. Inhibition of methylation alters its distribution between the nuclear and cytoplasmic compartments. Methylation may be required for its localization in subnuclear structures, such as nucleoli, nuclear speckles, Cajal bodies and Gemini of coiled bodies (gems). Colocalizes with FMR1, FXR1 and FXR2 in cytoplasmic stress granules (By similarity). In myocardial cells, localization at the sarcoplasm is reduced in response to mechanical stress (PubMed:15862299). {ECO:0000250|UniProtKB:Q5JVS0, ECO:0000269|PubMed:15862299}.
uniprot
proteins