SUMO4
entrez
387082
canonical
uniprot
Q6EEV6
canonical
ensembl
ENSG00000177688
resolver
ensp
ENSP00000318635
resolver
enst
ENST00000326669
resolver
genesymbol
SUMO4
resolver
genesymbol_syn
SMT3H4
resolver
hgnc
HGNC:21181
resolver
uniprot
A1L3W5
resolver
uniprot_entry
SUMO4_HUMAN
resolver
uniprot_sec
A1L3W5
resolver
amino_acid_sequence
MANEKPTEEVKTENNNHINLKVAGQDGSVVQFKIKRQTPLSKLMKAYCEPRGLSVKQIRFRFGGQPISGTDKPAQLEMEDEDTIDVFQQPTGGVY
uniprot
proteins
disease_involvement
DISEASE: Type 1 diabetes mellitus 5 (T1D5) [MIM:600320]: A form of diabetes mellitus, a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269|PubMed:15123604, ECO:0000269|PubMed:15247916, ECO:0000269|PubMed:15678134, ECO:0000269|PubMed:15678135, ECO:0000269|PubMed:15678137}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry. Valine at position 55 results in greater NFKB1 transcriptional activity and IL12B expression and may be associated with susceptibility to insulin-dependent diabetes mellitus. {ECO:0000269|PubMed:15123604, ECO:0000269|PubMed:15247916}.
uniprot
proteins
function
FUNCTION: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. {ECO:0000269|PubMed:15123604, ECO:0000269|PubMed:15247916, ECO:0000269|PubMed:16236267}.
uniprot
proteins
mass_dalton
10653
uniprot
proteins
post_translational_modification
PTM: In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates.
uniprot
proteins
protein_family
SUMO subfamily
uniprot
proteins
protein_family
Ubiquitin family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15123604
uniprot
proteins
pubmed
15247916
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15678134
uniprot
proteins
pubmed
15678135
uniprot
proteins
pubmed
15678137
uniprot
proteins
pubmed
16198310
uniprot
proteins
pubmed
16236267
uniprot
proteins
sequence_length
95
uniprot
proteins