Srsf2
entrez
494445
canonical
uniprot
Q6PDU1
canonical
ensembl
ENSRNOG00000000248
resolver
ensembl
ENSRNOG00055031602
resolver
ensembl
ENSRNOG00060023483
resolver
ensembl
ENSRNOG00065004914
resolver
ensp
ENSRNOP00000059012
resolver
ensp
ENSRNOP00055045227
resolver
ensp
ENSRNOP00060033621
resolver
ensp
ENSRNOP00065004962
resolver
enst
ENSRNOT00000067739
resolver
enst
ENSRNOT00055054720
resolver
enst
ENSRNOT00060040678
resolver
enst
ENSRNOT00065007152
resolver
genesymbol
Srsf2
resolver
genesymbol_syn
Sfrs2
resolver
uniprot_entry
SRSF2_RAT
resolver
amino_acid_sequence
MSYGRPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVYIPRDRYTKESRGFAFVRFHDKRDAEDAMDAMDGAVLDGRELRVQMARYGRPPDSHHSRRGPPPRRYGGGGYGRRSRSPRRRRRSRSRSRSRSRSRSRSRYSRSKSRSRTRSRSRSTSKSRSARRSKSKSSSVSRSRSRSRSRSRSRSPPPVSKRESKSRSRSKSPPKSPEEEGAVSS
uniprot
proteins
function
FUNCTION: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000250|UniProtKB:Q01130}.
uniprot
proteins
mass_dalton
25476
uniprot
proteins
post_translational_modification
PTM: Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by SRPK2 and this causes its redistribution from the nuclear speckle to nucleoplasm and controls cell fate decision in response to cisplatin treatment. KAT5/TIP60 inhibits its phosphorylation by preventing SRPK2 nuclear translocation. {ECO:0000250|UniProtKB:Q01130}.; PTM: Acetylation on Lys-52 by KAT5/TIP60 promotes its proteasomal degradation. This effect is counterbalanced by HDAC6, which positively controls SRSF2 protein level by deacetylating it and preventing its proteasomal degradation. {ECO:0000250|UniProtKB:Q01130}.
uniprot
proteins
protein_family
Splicing factor SR family
uniprot
proteins
pubmed
11683997
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q01130}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q01130}. Nucleus speckle {ECO:0000250|UniProtKB:Q01130}. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear speckle to nucleoplasm. {ECO:0000250|UniProtKB:Q01130}.
uniprot
proteins