Khdrbs1
entrez
117268
canonical
uniprot
Q91V33
canonical
ensembl
ENSRNOG00000046794
resolver
ensembl
ENSRNOG00055028072
resolver
ensembl
ENSRNOG00060024486
resolver
ensembl
ENSRNOG00065024942
resolver
ensp
ENSRNOP00000066894
resolver
ensp
ENSRNOP00055039938
resolver
ensp
ENSRNOP00060035158
resolver
ensp
ENSRNOP00065035080
resolver
enst
ENSRNOT00000075270
resolver
enst
ENSRNOT00055048583
resolver
enst
ENSRNOT00060042435
resolver
enst
ENSRNOT00065042864
resolver
genesymbol
Khdrbs1
resolver
genesymbol_syn
Sam68
resolver
uniprot_entry
KHDR1_RAT
resolver
amino_acid_sequence
MQRRDDPAARLTRSSGRSCSKDPSGAHPSVRLTPSRPSPLPHRSRGGGGGPRGGARASPATQPPPLLPPSNPGPDATVVGSAPTPLLPPSATAAAKMEPENKYLPELMAEKDSLDPSFTHAMQLLSVEIEKIQKGESKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELSYLNGVPEPSRGRGVSVRGRGAAPPPPPVPRGRGVGPPRGALVRGTPVRGSITRGATVTRGVPPPPTVRGAPTPRARTAGIQRIPLPPTPAPETYEDYGYDDSYAEQSYEGYEGYYSQSQGESEYYDYGHGELQDSYEAYGQDDWNGTRPSLKAPPARPVKGAYREHPYGRY
uniprot
proteins
function
FUNCTION: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. May not be involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species. RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner. In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1. Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q07666, ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:10437794}.
uniprot
proteins
mass_dalton
48315
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated by several non-receptor tyrosine kinases including LCK, FYN and JAK3. Also tyrosine phosphorylated by the non-receptor tyrosine kinase SRMS in an EGF-dependent manner. Phosphorylation by PTK6 negatively regulates its RNA binding ability. Phosphorylation by PTK6 at Tyr-440 dictates the nuclear localization of KHDRBS1. {ECO:0000250|UniProtKB:Q07666}.; PTM: Acetylated. Positively correlates with ability to bind RNA. Deacetylated by HDAC6; this regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons. {ECO:0000250|UniProtKB:Q07666}.; PTM: Arginine methylation is required for nuclear localization, Inhibits interaction with Src-like SH3 domains, but not interaction with WW domains of WBP4/FBP21 and FNBP4/FBP30. {ECO:0000250|UniProtKB:Q07666}.
uniprot
proteins
protein_family
KHDRBS family
uniprot
proteins
pubmed
10437794
uniprot
proteins
pubmed
10748127
uniprot
proteins
pubmed
15345239
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
443
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q07666}. Cytoplasm {ECO:0000250|UniProtKB:Q07666}. Membrane {ECO:0000250|UniProtKB:Q07666}. Note=Predominantly located in the nucleus but also located partially in the cytoplasm. {ECO:0000250|UniProtKB:Q07666}.
uniprot
proteins