Rgs7bp
entrez
52882
canonical
uniprot
Q8BQP9
canonical
ensembl
ENSMUSG00000021719
resolver
ensp
ENSMUSP00000066614
resolver
enst
ENSMUST00000063551
resolver
genesymbol
Rgs7bp
resolver
genesymbol_syn
D13Bwg1146e
resolver
genesymbol_syn
R7bp
resolver
uniprot
Q0VF69
resolver
uniprot
Q3UVC4
resolver
uniprot
Q8CBD6
resolver
uniprot
Q9CTP1
resolver
uniprot_entry
R7BP_MOUSE
resolver
uniprot_sec
Q0VF69
resolver
uniprot_sec
Q3UVC4
resolver
uniprot_sec
Q8CBD6
resolver
uniprot_sec
Q9CTP1
resolver
amino_acid_sequence
MSSAPNGRKKRPSRSTRSSIFQISKPPLQSGDWERRGSGSESAHKTQRALDDCKMLVQEFNTQVALYRELVISIGDVSVSCPSLRAEMHKTRTKGCEMARQAHQKLAAISGPEDGEIHPEICRLYIQLQCCLEMYTTEMLKSICLLGSLQFHRKGKEASGGAKNLDSKIEENAETPALEDSLSSPLESQQQCWQVATDIENTERDMREMKNLLSKLRETMPLPLKNQDDSSLLNLTPYPMVRRRKRRFFGLCCLVSS
uniprot
proteins
function
FUNCTION: Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation. {ECO:0000269|PubMed:15897264, ECO:0000269|PubMed:16574655, ECO:0000269|PubMed:16867977, ECO:0000269|PubMed:17158100}.
uniprot
proteins
mass_dalton
29023
uniprot
proteins
mutagenesis
MUTAGEN 242..247; /note="Missing: Abolishes nuclear localization and palmitoylation."; /evidence="ECO:0000269|PubMed:16867977"; MUTAGEN 243; /note="R->E: Abolishes nuclear localization; when associated with E-246."; /evidence="ECO:0000269|PubMed:16574655"; MUTAGEN 246; /note="R->E: Abolishes nuclear localization; when associated with E-243."; /evidence="ECO:0000269|PubMed:16574655"; MUTAGEN 252..253; /note="CC->AA: Abolishes palmitoylation."; /evidence="ECO:0000269|PubMed:16574655"; MUTAGEN 252; /note="C->S: Strongly reduces palmitoylation and its ability to regulate GPCR signaling. Abolishes palmitoylation and its ability to regulate GPCR signaling; when associated with S-253."; /evidence="ECO:0000269|PubMed:15897264"; MUTAGEN 253; /note="C->S: Strongly reduces palmitoylation and its ability to regulate GPCR signaling. Abolishes palmitoylation and its ability to regulate GPCR signaling; when associated with S-252."; /evidence="ECO:0000269|PubMed:15897264
uniprot
proteins
post_translational_modification
PTM: Palmitoylated (PubMed:15897264, PubMed:16574655, PubMed:21343290). Undergoes rapid palmitoylation turnover (PubMed:21343290). De novo and turnover palmitoylation are both mediated by ZDHHC2 (PubMed:21343290). Palmitoylation regulates the cell membrane and nuclear shuttling and the regulation of GPCR signaling (PubMed:15897264, PubMed:16574655, PubMed:16867977, PubMed:21343290). Upon depalmitoylation, it is targeted from the plasma membrane into the nucleus (PubMed:15897264, PubMed:16574655). GPCR signaling inhibits depalmitoylation and promotes localization to the plasma membrane (PubMed:21343290). {ECO:0000269|PubMed:15897264, ECO:0000269|PubMed:16574655, ECO:0000269|PubMed:16867977, ECO:0000269|PubMed:21343290}.
uniprot
proteins
protein_family
RGS7BP/RGS9BP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15632198
uniprot
proteins
pubmed
15897264
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16574655
uniprot
proteins
pubmed
16867977
uniprot
proteins
pubmed
17158100
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21343290
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15897264, ECO:0000269|PubMed:16574655, ECO:0000269|PubMed:16867977, ECO:0000269|PubMed:21343290}. Cytoplasm {ECO:0000269|PubMed:15897264, ECO:0000269|PubMed:16574655}. Cell membrane {ECO:0000269|PubMed:15897264, ECO:0000269|PubMed:16574655, ECO:0000269|PubMed:16867977, ECO:0000269|PubMed:21343290}; Lipid-anchor {ECO:0000269|PubMed:15897264, ECO:0000269|PubMed:16867977}. Note=Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation (PubMed:15897264, PubMed:21343290). {ECO:0000269|PubMed:15897264, ECO:0000269|PubMed:21343290}.
uniprot
proteins