DENND6A
entrez
201627
canonical
uniprot
Q8IWF6
canonical
ensembl
ENSG00000174839
resolver
ensp
ENSP00000311401
resolver
ensp
ENSP00000562404
resolver
enst
ENST00000311128
resolver
genesymbol
DENND6A
resolver
genesymbol_syn
FAM116A
resolver
hgnc
HGNC:26635
resolver
uniprot
Q7Z5T4
resolver
uniprot
Q8N235
resolver
uniprot
Q8TEG8
resolver
uniprot_entry
DEN6A_HUMAN
resolver
uniprot_sec
Q7Z5T4
resolver
uniprot_sec
Q8N235
resolver
uniprot_sec
Q8TEG8
resolver
amino_acid_sequence
MALRGPAGLGPGSRRPLDEAVAGAEGREAPALVAAGGAPEDDEEDDGRGRGLLRWDSFSAWLHCVCVVGFDLELGQAVEVIYPQHSKLTDREKTNICYLSFPDSNSGCLGDTQFCFRFRQSSGRRVSLHCLLDQFDKDLPVYLKKDPAYFYGYVYFRQVRDKTLKRGYFQKSLVLISKLPYIHFFHTVLKQIAPEYFEKNEPYLEAACNDVDRWPAPVPGKTLHLPIMGVVMKVRIPTCHDKPGTTQIVQLTQQVDTNISVILPTVHEVDIFRCFCPVFLHSQMLWELVLLGEPLVVMAPSPSESSETVLALVNCISPLKYFSDFRPYFTIHDSEFKEYTTRTQAPPSVILGVTNPFFAKTLQHWPHIIRIGDLKPTGEIPKQVKVKKLKNLKTLDSKPGVYTSYKPYLNRDEEIIKQLQKGVQQKRPSEAQSVILRRYFLELTQSFIIPLERYVASLMPLQKSISPWKSPPQLRQFLPEEFMKTLEKTGPQLTSRIKGDWIGLYRHFLKSPNFDGWFKTRRKEMTQKLEALHLEALCEEDLLLWIQKHTEVETVDLVLKLKNKLLQADREHLPVKPDTMEKLRTHIDAIILALPEDLQGILLKTGMT
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes. {ECO:0000269|PubMed:22595670}.
uniprot
proteins
mass_dalton
69575
uniprot
proteins
protein_family
DENND6 family
uniprot
proteins
pubmed
12693554
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21330364
uniprot
proteins
pubmed
22595670
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
608
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome {ECO:0000269|PubMed:22595670}. Cytoplasm {ECO:0000269|PubMed:22595670}.
uniprot
proteins