CTPS2
entrez
56474
canonical
uniprot
Q9NRF8
canonical
ensembl
ENSG00000047230
resolver
ensp
ENSP00000352222
resolver
ensp
ENSP00000369590
resolver
ensp
ENSP00000401264
resolver
ensp
ENSP00000540473
resolver
ensp
ENSP00000540474
resolver
ensp
ENSP00000540475
resolver
ensp
ENSP00000540476
resolver
ensp
ENSP00000540477
resolver
ensp
ENSP00000540478
resolver
ensp
ENSP00000540480
resolver
ensp
ENSP00000540481
resolver
ensp
ENSP00000540483
resolver
ensp
ENSP00000540484
resolver
ensp
ENSP00000540487
resolver
ensp
ENSP00000583932
resolver
ensp
ENSP00000583934
resolver
ensp
ENSP00000615038
resolver
ensp
ENSP00000615041
resolver
ensp
ENSP00000615042
resolver
ensp
ENSP00000615044
resolver
ensp
ENSP00000615046
resolver
ensp
ENSP00000615048
resolver
enst
ENST00000359276
resolver
enst
ENST00000380241
resolver
enst
ENST00000443824
resolver
enst
ENST00000870414
resolver
enst
ENST00000870415
resolver
enst
ENST00000870416
resolver
enst
ENST00000870417
resolver
enst
ENST00000870418
resolver
enst
ENST00000870419
resolver
enst
ENST00000870421
resolver
enst
ENST00000870422
resolver
enst
ENST00000870424
resolver
enst
ENST00000870425
resolver
enst
ENST00000870428
resolver
enst
ENST00000913873
resolver
enst
ENST00000913875
resolver
enst
ENST00000944979
resolver
enst
ENST00000944982
resolver
enst
ENST00000944983
resolver
enst
ENST00000944985
resolver
enst
ENST00000944987
resolver
enst
ENST00000944989
resolver
genesymbol
CTPS2
resolver
hgnc
HGNC:2520
resolver
uniprot
B3KWM2
resolver
uniprot
Q9BRI0
resolver
uniprot
Q9H809
resolver
uniprot
Q9H8K9
resolver
uniprot_entry
PYRG2_HUMAN
resolver
uniprot_sec
B3KWM2
resolver
uniprot_sec
Q9BRI0
resolver
uniprot_sec
Q9H809
resolver
uniprot_sec
Q9H8K9
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by CTP. {ECO:0000269|PubMed:34583994}.
uniprot
proteins
amino_acid_sequence
MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYINIDAGTFSPYEHGEVFVLNDGGEVDLDLGNYERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDAVQEWVMNQAKVPVDGNKEEPQICVIELGGTIGDIEGMPFVEAFRQFQFKAKRENFCNIHVSLVPQLSATGEQKTKPTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSTYRVPVLLEEQSIVKYFKERLHLPIGDSASNLLFKWRNMADRYERLQKICSIALVGKYTKLRDCYASVFKALEHSALAINHKLNLMYIDSIDLEKITETEDPVKFHEAWQKLCKADGILVPGGFGIRGTLGKLQAISWARTKKIPFLGVCLGMQLAVIEFARNCLNLKDADSTEFRPNAPVPLVIDMPEHNPGNLGGTMRLGIRRTVFKTENSILRKLYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFVGQDVDGDRMEIIELANHPYFVGVQFHPEFSSRPMKPSPPYLGLLLAATGNLNAYLQQGCKLSSSDRYSDASDDSFSEPRIAELEIS
uniprot
proteins
ec_number
6.3.4.2
uniprot
proteins
function
FUNCTION: CTP synthase involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen (PubMed:10899599, PubMed:16179339, PubMed:31873303, PubMed:34583994). Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (PubMed:10899599, PubMed:16179339). {ECO:0000269|PubMed:10899599, ECO:0000269|PubMed:16179339, ECO:0000269|PubMed:31873303, ECO:0000269|PubMed:34583994}.
uniprot
proteins
mass_dalton
65678
uniprot
proteins
mutagenesis
MUTAGEN 250; /note="T->I: Promotes inhibition by small compound R80."; /evidence="ECO:0000269|PubMed:34583994"; MUTAGEN 355; /note="H->A: Abolished ability to polymerize into filaments."; /evidence="ECO:0000269|PubMed:31873303
uniprot
proteins
pathway_participation
PATHWAY: Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. {ECO:0000269|PubMed:16179339, ECO:0000269|PubMed:31873303, ECO:0000269|PubMed:34583994}.
uniprot
proteins
protein_family
CTP synthase family
uniprot
proteins
pubmed
10899599
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16179339
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24503052
uniprot
proteins
pubmed
31873303
uniprot
proteins
pubmed
34583994
uniprot
proteins
sequence_length
586
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24503052}. Nucleus {ECO:0000269|PubMed:24503052}. Note=Cytoplasmic and nuclear; detected in long filamentous structures named cytoophidium. {ECO:0000269|PubMed:24503052}.
uniprot
proteins