GAP43
entrez
2596
canonical
uniprot
P17677
canonical
ensembl
ENSG00000172020
resolver
ensp
ENSP00000305010
resolver
ensp
ENSP00000377372
resolver
genesymbol
GAP43
resolver
hgnc
HGNC:4140
resolver
uniprot
A8K0Y4
resolver
uniprot
Q5U058
resolver
uniprot_entry
NEUM_HUMAN
resolver
uniprot_entry
Q5U058_HUMAN
resolver
uniprot_sec
A8K0Y4
resolver
amino_acid_sequence
MLCCMRRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA
uniprot
proteins
function
FUNCTION: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}.
uniprot
proteins
mass_dalton
24803
uniprot
proteins
mutagenesis
MUTAGEN 3..4; /note="CC->SS: Inhibits axonal and dendritic filopodia formation and reduces dendritic and axonal branching."; /evidence="ECO:0000269|PubMed:14978216
uniprot
proteins
post_translational_modification
PTM: Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:P07936}.; PTM: Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction (PubMed:14978216). Deacylated by LYPLA2 (PubMed:21152083). {ECO:0000250|UniProtKB:P06837, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}.
uniprot
proteins
protein_family
Neuromodulin family
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14978216
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
21152083
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
3272162
uniprot
proteins
pubmed
3272163
uniprot
proteins
pubmed
8231732
uniprot
proteins
sequence_length
238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14978216}; Peripheral membrane protein {ECO:0000269|PubMed:14978216}; Cytoplasmic side {ECO:0000269|PubMed:14978216}. Cell projection, growth cone membrane {ECO:0000269|PubMed:14978216}; Peripheral membrane protein {ECO:0000269|PubMed:14978216}; Cytoplasmic side {ECO:0000269|PubMed:14978216}. Synapse {ECO:0000269|PubMed:14978216}. Cell projection, filopodium membrane {ECO:0000269|PubMed:14978216}; Peripheral membrane protein {ECO:0000269|PubMed:14978216}. Perikaryon {ECO:0000250|UniProtKB:P07936}. Cell projection, dendrite {ECO:0000250|UniProtKB:P07936}. Cell projection, axon {ECO:0000250|UniProtKB:P07936}. Cytoplasm {ECO:0000250|UniProtKB:P07936}. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes. {ECO:0000269|PubMed:14978216}.
uniprot
proteins