Alox15
entrez
81639
canonical
uniprot
Q02759
canonical
ensembl
ENSRNOG00000019183
resolver
ensembl
ENSRNOG00055032645
resolver
ensembl
ENSRNOG00060029354
resolver
ensembl
ENSRNOG00065028140
resolver
ensp
ENSRNOP00000026038
resolver
ensp
ENSRNOP00000091973
resolver
ensp
ENSRNOP00055046516
resolver
ensp
ENSRNOP00060042397
resolver
ensp
ENSRNOP00065039765
resolver
enst
ENSRNOT00000026038
resolver
enst
ENSRNOT00000113835
resolver
enst
ENSRNOT00055056410
resolver
enst
ENSRNOT00060050968
resolver
enst
ENSRNOT00065048499
resolver
genesymbol
Alox15
resolver
genesymbol_syn
Alox12l
resolver
uniprot
A0A8I6AV04
resolver
uniprot
F1MA51
resolver
uniprot_entry
A0A8I6AV04_RAT
resolver
uniprot_entry
LOX15_RAT
resolver
uniprot_sec
F1MA51
resolver
amino_acid_sequence
MGVYRIRVSTGDSKYAGSNNEVYLWLVGQHGEASLGKLLRPCRDSEAEFKVDVSEYLGPLLFVRVQKWHYLTDDAWFCNWISVKGPGDQGSEYMFPCYRWVQGRSILSLPEGTGCTVVEDSQGLFRKHREEELEERRSLYRWGNWKDGSILNVAAASISDLPVDQRFREDKRIEFEASQVIGVMDTVVNFPINTVTCWKSLDDFNCVFKSGHTKMAERVRNSWKEDAFFGYQFLNGANPMVLKRSTCLPARLVFPPGMEKLQAQLNKELQKGTLFEADFFLLDGIKANVILCSQQYLAAPLVMLKLMPDGQLLPIAIQLELPKTGSTPPPIFTPSDPPMDWLLAKCWVRSSDLQLHELQAHLLRGHLMAEVFAVATMRCLPSVHPVFKLLVPHLLYTMEINVRARSDLISERGFFDKAMSTGGGGHLDLLKQAGAFLTYCSLCPPDDLAERGLLDIETCFYAKDALRLWQIMNRYVVGMFNLHYKTDKAVQDDYELQSWCREITDIGLQGAQDRGFPTSLQSRAQACYFITMCIFTCTAQHSSVHLGQLDWFYWVPNAPCTMRLPPPTTKEATMEKLMATLPNPNQSTLQINVVWLLGRRQAVMVPLGQHSEEHFPNPEAKAVLKKFREELAALDKEIEIRNKSLDIPYEYLRPSMVENSVAI
uniprot
proteins
ec_number
1.13.11.-
uniprot
proteins
ec_number
1.13.11.12
uniprot
proteins
ec_number
1.13.11.31
uniprot
proteins
ec_number
1.13.11.33
uniprot
proteins
function
FUNCTION: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:15123652, PubMed:23382512, PubMed:8117750, PubMed:8444196). It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE (PubMed:15123652, PubMed:23382512, PubMed:8117750, PubMed:8444196). It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties (PubMed:15123652, PubMed:23382512). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate. May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets. Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (By similarity). Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response. In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties. Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells. It is also implicated in the generation of endogenous ligands for peroxisome proliferator activated receptor (PPAR-gamma), hence modulating macrophage development and function. It may also exert a negative effect on skeletal development by regulating bone mass through this pathway. As well as participates in ER stress and downstream inflammation in adipocytes, pancreatic islets, and liver (By similarity). Finally, it is also involved in the cellular response to IL13/interleukin-13 (By similarity). {ECO:0000250|UniProtKB:P16050, ECO:0000250|UniProtKB:P39654, ECO:0000269|PubMed:15123652, ECO:0000269|PubMed:23382512, ECO:0000269|PubMed:8117750, ECO:0000269|PubMed:8444196}.
uniprot
proteins
mass_dalton
75378
uniprot
proteins
mutagenesis
MUTAGEN 353; /note="L->F: Decreases arachidonic acid 12 lipoxygenase. Exhibits an arachidonic acid 15 lipoxygenase. Decreases hepoxilin A3 synthase activity."; /evidence="ECO:0000269|PubMed:15123652"; MUTAGEN 417; /note="K->Q: Does not affect arachidonic acid 12 lipoxygenase. Does not affect hepoxilin A3 synthase activity."; /evidence="ECO:0000269|PubMed:15123652"; MUTAGEN 418; /note="A->I: Does not affect arachidonic acid 12 lipoxygenase. Does not affect hepoxilin A3 synthase activity."; /evidence="ECO:0000269|PubMed:15123652
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. {ECO:0000269|PubMed:15123652, ECO:0000269|PubMed:8117750, ECO:0000269|PubMed:8444196}.
uniprot
proteins
protein_family
Lipoxygenase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15123652
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23382512
uniprot
proteins
pubmed
8117750
uniprot
proteins
pubmed
8444196
uniprot
proteins
sequence_length
663
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15123652, ECO:0000269|PubMed:8117750}. Cell membrane {ECO:0000250|UniProtKB:P16050}; Peripheral membrane protein {ECO:0000250|UniProtKB:P16050}. Lipid droplet {ECO:0000250|UniProtKB:P16050}. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding. Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells. {ECO:0000250|UniProtKB:P39654}.
uniprot
proteins