Fxr1
entrez
14359
canonical
uniprot
Q61584
canonical
ensembl
ENSMUSG00000027680
resolver
ensp
ENSMUSP00000001620
resolver
ensp
ENSMUSP00000130216
resolver
ensp
ENSMUSP00000142441
resolver
ensp
ENSMUSP00000142847
resolver
ensp
ENSMUSP00000143392
resolver
ensp
ENSMUSP00000319262
resolver
ensp
ENSMUSP00000319269
resolver
ensp
ENSMUSP00000319276
resolver
enst
ENSMUST00000198051
resolver
genesymbol
Fxr1
resolver
genesymbol_syn
Fxr1h
resolver
uniprot
A0A0G2JEP0
resolver
uniprot
Q8VCU4
resolver
uniprot
Q9R1E2
resolver
uniprot
Q9R1E3
resolver
uniprot
Q9R1E4
resolver
uniprot
Q9R1E5
resolver
uniprot
Q9WUA7
resolver
uniprot
Q9WUA8
resolver
uniprot
Q9WUA9
resolver
uniprot_entry
A0A0G2JEP0_MOUSE
resolver
uniprot_entry
FXR1_MOUSE
resolver
uniprot_sec
Q8VCU4
resolver
uniprot_sec
Q9R1E2
resolver
uniprot_sec
Q9R1E3
resolver
uniprot_sec
Q9R1E4
resolver
uniprot_sec
Q9R1E5
resolver
uniprot_sec
Q9WUA7
resolver
uniprot_sec
Q9WUA8
resolver
uniprot_sec
Q9WUA9
resolver
amino_acid_sequence
MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEISEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAIELDEDTGTFRIYGESAEAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGMGFRPSSTRGPEREKGYATDESTVSSVQGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRETRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRRRRTDEDAVLMDGLTESDTASVNENGLDDSEKKPQRRNRSRRRRFRGQAEDRQPVTVADYISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDEIPKLPRTLGEEKTKTLKEDSTQEAAVLNGVS
uniprot
proteins
function
FUNCTION: mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:15128702, PubMed:25456134, PubMed:32328638, PubMed:35951695). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:25456134). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:32328638, PubMed:35951695). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (PubMed:35951695). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (By similarity). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (By similarity). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (PubMed:15548538). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (PubMed:25456134). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (PubMed:28204491). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (PubMed:32893934). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:15128702, PubMed:32328638). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (By similarity). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (By similarity). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (By similarity). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (By similarity). {ECO:0000250|UniProtKB:P51114, ECO:0000269|PubMed:15128702, ECO:0000269|PubMed:15548538, ECO:0000269|PubMed:25456134, ECO:0000269|PubMed:28204491, ECO:0000269|PubMed:32328638, ECO:0000269|PubMed:32893934, ECO:0000269|PubMed:35951695}.
uniprot
proteins
mass_dalton
76222
uniprot
proteins
mutagenesis
MUTAGEN 351; /note="L->P: Abolished ability to undergo liquid-liquid phase separation and promote translation of target mRNAs. Male infertility in knokin mice."; /evidence="ECO:0000269|PubMed:35951695"; MUTAGEN 409; /note="S->A: Decreased phosphorylation by GSK3B."; /evidence="ECO:0000269|PubMed:26240334"; MUTAGEN 426; /note="S->A: Decreased phosphorylation by GSK3B."; /evidence="ECO:0000269|PubMed:26240334"; MUTAGEN 438; /note="S->A: Decreased phosphorylation by GSK3B."; /evidence="ECO:0000269|PubMed:26240334"; MUTAGEN 492; /note="S->A: Decreased phosphorylation by GSK3B."; /evidence="ECO:0000269|PubMed:26240334"; MUTAGEN 503; /note="S->A: Decreased phosphorylation by GSK3B."; /evidence="ECO:0000269|PubMed:26240334"; MUTAGEN 525; /note="S->A: Decreased phosphorylation by GSK3B."; /evidence="ECO:0000269|PubMed:26240334"; MUTAGEN 551; /note="T->A: Decreased phosphorylation by GSK3B."; /evidence="ECO:0000269|PubMed:26240334"; MUTAGEN 553; /note="S->A: Decreased phosphorylation by GSK3B."; /evidence="ECO:0000269|PubMed:26240334"; MUTAGEN 598; /note="S->A: Decreased phosphorylation by GSK3B."; /evidence="ECO:0000269|PubMed:26240334
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-449 by PAK1 promotes its relocalization to stress granules and activity (By similarity). Phosphorylated by MAPK1/ERK2, promoting subsequent phosphorylation by GSK3B (PubMed:26240334). Phosphorylated by GSK3B, promoting ubiquitination and degradation by the proteasome (PubMed:26240334, PubMed:29142209, PubMed:32893934). {ECO:0000250|UniProtKB:P51114, ECO:0000269|PubMed:26240334, ECO:0000269|PubMed:29142209, ECO:0000269|PubMed:32893934}.; PTM: Ubiquitinated by the SCF(FBXO4) complex, leading to its degradation by the proteasome: ubiquitination by the SCF(FBXO4) complex takes place following phosphorylation by GSK3B (PubMed:26240334, PubMed:29142209, PubMed:32893934). Ubiquitinated and degraded in a GSK3B-dependent manner in during both scaling and sleep deprivation (PubMed:32893934). Ubiquitinated via 'Lys-63'-linked ubiquitin, leading to its degradation: interaction with CEP63 inhibits 'Lys-63'-linked ubiquitination (By similarity). {ECO:0000250|UniProtKB:P51114, ECO:0000269|PubMed:26240334, ECO:0000269|PubMed:29142209, ECO:0000269|PubMed:32893934}.
uniprot
proteins
protein_family
FMR1 family
uniprot
proteins
pubmed
10409431
uniprot
proteins
pubmed
11438699
uniprot
proteins
pubmed
15128702
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15548538
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16000371
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22022532
uniprot
proteins
pubmed
25456134
uniprot
proteins
pubmed
26240334
uniprot
proteins
pubmed
27770568
uniprot
proteins
pubmed
28204491
uniprot
proteins
pubmed
29142209
uniprot
proteins
pubmed
30770808
uniprot
proteins
pubmed
32328638
uniprot
proteins
pubmed
32893934
uniprot
proteins
pubmed
35951695
uniprot
proteins
pubmed
8634689
uniprot
proteins
sequence_length
677
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:22022532, ECO:0000269|PubMed:35951695}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P51114}. Cytoplasm {ECO:0000305|PubMed:30770808}. Cell projection, dendrite {ECO:0000269|PubMed:22022532}. Cell projection, dendritic spine {ECO:0000269|PubMed:22022532}. Cell projection, axon {ECO:0000269|PubMed:22022532}. Nucleus envelope {ECO:0000250|UniProtKB:P51114}. Postsynapse {ECO:0000269|PubMed:27770568}. Note=Specifically localizes to cytoplasmic ribonucleoprotein membraneless compartments (PubMed:35951695). Localizes to stress granules following phosphorylation at Ser-449 by PAK1 (By similarity). Adjacent to Z-lines in muscles (PubMed:30770808). {ECO:0000250|UniProtKB:P51114, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:35951695}.
uniprot
proteins