FER
entrez
2241
canonical
uniprot
P16591
canonical
ensembl
ENSG00000151422
resolver
ensp
ENSP00000281092
resolver
ensp
ENSP00000484767
resolver
ensp
ENSP00000550829
resolver
ensp
ENSP00000550831
resolver
ensp
ENSP00000610407
resolver
ensp
ENSP00000628894
resolver
ensp
ENSP00000628895
resolver
ensp
ENSP00000780857
resolver
ensp
ENSP00000782238
resolver
genesymbol
FER
resolver
genesymbol_syn
TYK3
resolver
hgnc
HGNC:3655
resolver
uniprot
B2RCR4
resolver
uniprot
B4DSQ2
resolver
uniprot
H2FLB8
resolver
uniprot
Q6PEJ9
resolver
uniprot_entry
FER_HUMAN
resolver
uniprot_entry
Q6PEJ9_HUMAN
resolver
uniprot_sec
B2RCR4
resolver
uniprot_sec
B4DSQ2
resolver
uniprot_sec
H2FLB8
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphatidic acid binding. Activated by hydrogen peroxide (in vitro). Activated by reactive oxygen species (ROS). {ECO:0000269|PubMed:19738202}.
uniprot
proteins
amino_acid_sequence
MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. {ECO:0000269|PubMed:12972546, ECO:0000269|PubMed:14517306, ECO:0000269|PubMed:19147545, ECO:0000269|PubMed:19339212, ECO:0000269|PubMed:19738202, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21518868, ECO:0000269|PubMed:22223638, ECO:0000269|PubMed:7623846, ECO:0000269|PubMed:9722593}.
uniprot
proteins
mass_dalton
94638
uniprot
proteins
mutagenesis
MUTAGEN 483; /note="R->Q: Abolishes kinase activity. Abolishes location at microtubules."; /evidence="ECO:0000269|PubMed:12972546"; MUTAGEN 591; /note="K->R: Abolishes kinase activity."; /evidence="ECO:0000269|PubMed:9722593
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21518868}.; PTM: Polyubiquitinated; this leads to proteasomal degradation. {ECO:0000250}.
uniprot
proteins
protein_family
Fes/fps subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
11994747
uniprot
proteins
pubmed
12972546
uniprot
proteins
pubmed
14517306
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
16418535
uniprot
proteins
pubmed
1651563
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18985748
uniprot
proteins
pubmed
19147545
uniprot
proteins
pubmed
19159681
uniprot
proteins
pubmed
19339212
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19738202
uniprot
proteins
pubmed
1990274
uniprot
proteins
pubmed
20111072
uniprot
proteins
pubmed
21518868
uniprot
proteins
pubmed
2156206
uniprot
proteins
pubmed
22223638
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2725517
uniprot
proteins
pubmed
7623846
uniprot
proteins
pubmed
8247543
uniprot
proteins
pubmed
9722593
uniprot
proteins
sequence_length
822
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Note=Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts.
uniprot
proteins