Derl2
entrez
116891
canonical
uniprot
Q8BNI4
canonical
ensembl
ENSMUSG00000018442
resolver
ensp
ENSMUSP00000117052
resolver
ensp
ENSMUSP00000127568
resolver
ensp
ENSMUSP00000334141
resolver
enst
ENSMUST00000171041
resolver
genesymbol
Derl2
resolver
genesymbol_syn
Der2
resolver
genesymbol_syn
Flana
resolver
uniprot
F6TBL9
resolver
uniprot
Q3U957
resolver
uniprot
Q920I5
resolver
uniprot
Q99J12
resolver
uniprot_entry
DERL2_MOUSE
resolver
uniprot_entry
F6TBL9_MOUSE
resolver
uniprot_entry
Q3U957_MOUSE
resolver
uniprot_sec
Q920I5
resolver
uniprot_sec
Q99J12
resolver
amino_acid_sequence
MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITNFLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFLGQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGHIYFFLEDIFPNQPGGIRILKTPSILRTIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
uniprot
proteins
function
FUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. {ECO:0000250|UniProtKB:Q9GZP9}.
uniprot
proteins
mass_dalton
27640
uniprot
proteins
protein_family
Derlin family
uniprot
proteins
pubmed
11500051
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16186509
uniprot
proteins
pubmed
16449189
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22016385
uniprot
proteins
pubmed
25009997
uniprot
proteins
sequence_length
239
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9GZP9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9GZP9}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..78; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 97..117; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 151..171; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical; Name=4"; /evidence="ECO:0000255
uniprot
proteins