Mknk1
entrez
17346
canonical
uniprot
O08605
canonical
ensembl
ENSMUSG00000028708
resolver
ensp
ENSMUSP00000019677
resolver
ensp
ENSMUSP00000102123
resolver
ensp
ENSMUSP00000309524
resolver
enst
ENSMUST00000019677
resolver
enst
ENSMUST00000106513
resolver
genesymbol
Mknk1
resolver
genesymbol_syn
Mnk1
resolver
uniprot
A2A8W8
resolver
uniprot
Q3U1I8
resolver
uniprot_entry
A2A8W8_MOUSE
resolver
uniprot_entry
MKNK1_MOUSE
resolver
uniprot_entry
Q3U1I8_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway. {ECO:0000269|PubMed:9155017}.
uniprot
proteins
amino_acid_sequence
MVSSQKLEKPIEMGSSEPLPIVDSDKRRKKKRKTRATDSLPGKFEDVYQLTSELLGEGAYAKVQGAVNLQSGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNRNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKRKHFNEREASRVVRDVATALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGVKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFRDEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRMCQNKLFESIQEGKYEFPDKDWAHISNEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPERGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEQEALAEGLCSMKLSPPSKSRLARRRALAQAGRSRDANPCLTPAGL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:9155017}.
uniprot
proteins
mass_dalton
47915
uniprot
proteins
mutagenesis
MUTAGEN 209; /note="T->A: Loss of kinase activity; when associated with T-214."; /evidence="ECO:0000269|PubMed:9155017"; MUTAGEN 214; /note="T->A: Loss of kinase activity; when associated with T-209."; /evidence="ECO:0000269|PubMed:9155017
uniprot
proteins
post_translational_modification
PTM: Dual phosphorylation of Thr-209 and Thr-214 activates the kinase. Phosphorylation of Thr-344 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15234964
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9155017
uniprot
proteins
sequence_length
427
uniprot
proteins