RNF39
entrez
80352
canonical
uniprot
Q9H2S5
canonical
ensembl
ENSG00000204618
resolver
ensembl
ENSG00000206500
resolver
ensembl
ENSG00000227171
resolver
ensembl
ENSG00000230332
resolver
ensembl
ENSG00000230467
resolver
ensembl
ENSG00000235022
resolver
ensembl
ENSG00000236967
resolver
ensembl
ENSG00000237733
resolver
ensp
ENSP00000244360
resolver
ensp
ENSP00000365941
resolver
ensp
ENSP00000365942
resolver
ensp
ENSP00000407248
resolver
ensp
ENSP00000408539
resolver
enst
ENST00000244360
resolver
enst
ENST00000376750
resolver
enst
ENST00000376751
resolver
enst
ENST00000417541
resolver
enst
ENST00000449145
resolver
genesymbol
RNF39
resolver
genesymbol_syn
HZFW
resolver
hgnc
HGNC:18064
resolver
uniprot
A2BEK3
resolver
uniprot
A6NCD6
resolver
uniprot
B0S858
resolver
uniprot
Q5SPM8
resolver
uniprot
Q5SPM9
resolver
uniprot
Q5SPN0
resolver
uniprot
Q5SRJ9
resolver
uniprot
Q5SRK1
resolver
uniprot
Q5SS29
resolver
uniprot
Q9H2S3
resolver
uniprot
Q9H2S4
resolver
uniprot_entry
RNF39_HUMAN
resolver
uniprot_sec
A2BEK3
resolver
uniprot_sec
A6NCD6
resolver
uniprot_sec
B0S858
resolver
uniprot_sec
Q5SPM8
resolver
uniprot_sec
Q5SPM9
resolver
uniprot_sec
Q5SPN0
resolver
uniprot_sec
Q5SRJ9
resolver
uniprot_sec
Q5SRK1
resolver
uniprot_sec
Q5SS29
resolver
uniprot_sec
Q9H2S3
resolver
uniprot_sec
Q9H2S4
resolver
amino_acid_sequence
MWWRDLTRLRLWLKREAIPGEGRKAAKVNAGVGEKGIYTASSRGGPPSARSKAVTVVAEGAASRSWLSMDAPELGPGLVERLEQLATCPLCGGSFEDPVLLACEHSFCRACLARRWGTPPATGTEASPTACPCCGLPCPRRSLRSNVRLAVEVRISRELREKLAEPGARAGRRRGGRIPTMGCLDLPGEDMRKTWRRFEVPTSKSSNSEDDLPEDYPVVKKMLHRLTADLTLDPGTAHRRLLISADRRSVQLAPPGTPAPPDGPKRFDQLPAVLGAQGFGAGRHCWEVETADAASCRDSSGEDADDEESHYAVGAAGESVQRKGCVRLCPAGAVWAVEGRGGRLWALTAPEPTLLGGVEPPPRRIRVDLDWERGRVAFYDGRSLDLLYAFQAPGPLGERIFPLFCTCDPRAPLRIVPAES
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Plays an inhibitory role in anti-RNA viral innate immunity by targeting the adapter DDX3X and promoting its 'Lys-48'-linked polyubiquitination (PubMed:33674311). Alternatively, enhances the cGAS-STING pathway activation by promoting 'Lys-63'-linked ubiquitination of STING1, facilitating the STING1-TBK1 complex formation and STING1 activation (PubMed:39255680). {ECO:0000269|PubMed:33674311, ECO:0000269|PubMed:39255680}.; FUNCTION: (Microbial infection) Plays a positive role in human immunodeficiency virus (HIV-1) replication. {ECO:0000269|PubMed:25126410}.
uniprot
proteins
mass_dalton
45525
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="C->S: Complete loss of E3 ligase activity."; /evidence="ECO:0000269|PubMed:33674311, ECO:0000269|PubMed:39255680
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
11130983
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
25126410
uniprot
proteins
pubmed
33674311
uniprot
proteins
pubmed
39255680
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:33674311}.
uniprot
proteins