Inpp4a
entrez
269180
canonical
uniprot
Q9EPW0
canonical
ensembl
ENSMUSG00000026113
resolver
ensp
ENSMUSP00000027287
resolver
ensp
ENSMUSP00000057233
resolver
ensp
ENSMUSP00000110583
resolver
ensp
ENSMUSP00000115249
resolver
ensp
ENSMUSP00000121107
resolver
ensp
ENSMUSP00000121518
resolver
ensp
ENSMUSP00000121803
resolver
ensp
ENSMUSP00000123071
resolver
ensp
ENSMUSP00000130443
resolver
ensp
ENSMUSP00000284435
resolver
ensp
ENSMUSP00000284436
resolver
ensp
ENSMUSP00000284438
resolver
ensp
ENSMUSP00000284445
resolver
ensp
ENSMUSP00000284446
resolver
ensp
ENSMUSP00000284450
resolver
ensp
ENSMUSP00000284451
resolver
ensp
ENSMUSP00000284452
resolver
enst
ENSMUST00000027287
resolver
enst
ENSMUST00000058307
resolver
enst
ENSMUST00000114933
resolver
enst
ENSMUST00000132401
resolver
enst
ENSMUST00000132615
resolver
enst
ENSMUST00000136846
resolver
enst
ENSMUST00000137266
resolver
enst
ENSMUST00000140264
resolver
genesymbol
Inpp4a
resolver
uniprot
A0A0R4J0Q2
resolver
uniprot
A0ACM8Q8J4
resolver
uniprot
D3YTM1
resolver
uniprot
D3YUD3
resolver
uniprot
D3YUL8
resolver
uniprot
D3Z230
resolver
uniprot
E9Q9A0
resolver
uniprot
E9QAD0
resolver
uniprot
F6V2U0
resolver
uniprot
Q3UEQ1
resolver
uniprot
Q8CBJ8
resolver
uniprot_entry
A0A0R4J0Q2_MOUSE
resolver
uniprot_entry
A0ACM8Q8J4_MOUSE
resolver
uniprot_entry
D3YUD3_MOUSE
resolver
uniprot_entry
D3YUL8_MOUSE
resolver
uniprot_entry
D3Z230_MOUSE
resolver
uniprot_entry
E9Q9A0_MOUSE
resolver
uniprot_entry
E9QAD0_MOUSE
resolver
uniprot_entry
F6V2U0_MOUSE
resolver
uniprot_entry
INP4A_MOUSE
resolver
uniprot_entry
Q3UEQ1_MOUSE
resolver
uniprot_sec
D3YTM1
resolver
uniprot_sec
Q8CBJ8
resolver
amino_acid_sequence
MTAREHSPRHGARARAMQRASTIDVAADMVGLSLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQIKLSVYDVKDRSQGTMYLLGSGTFVVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQQPPVTRFLDTVNGRMVLPVDESLTEALGIRSKYAFLRKDSLLKAVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYKGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDVVTIGAPAAHCQGFKSGGLRKKLHKFEEAKKHSFEECCTSSSGQSIIYIPQDITRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWAGRSSRSSLQVDWHEEEWQKVWLNVDKSLECIIQRVDKLLQKDRLHGEGCEDAFPCSSTCSSKKDCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKAAMVFLLMQDSAPTIASYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDGGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSNASSDMLPVITGNRDGFNVRIPLPGPLVDSFPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEGINGESLVRVNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEVCRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET
uniprot
proteins
ec_number
3.1.3.66
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PubMed:20463662). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:11087841, PubMed:19325558). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (PubMed:20463662). {ECO:0000250|UniProtKB:Q62784, ECO:0000269|PubMed:11087841, ECO:0000269|PubMed:19325558, ECO:0000269|PubMed:20463662}.
uniprot
proteins
mass_dalton
105540
uniprot
proteins
pathway_participation
PATHWAY: Signal transduction; phosphatidylinositol signaling pathway.
uniprot
proteins
protein_family
4-bisphosphate 4-phosphatase family
uniprot
proteins
protein_family
Inositol 3
uniprot
proteins
pubmed
11087841
uniprot
proteins
pubmed
11485317
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19325558
uniprot
proteins
pubmed
20463662
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25869668
uniprot
proteins
sequence_length
939
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:Q96PE3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q96PE3}. Cell membrane {ECO:0000250|UniProtKB:Q96PE3}. Nucleus {ECO:0000250|UniProtKB:Q96PE3}. Cytoplasm {ECO:0000250|UniProtKB:Q96PE3}. Postsynaptic density {ECO:0000269|PubMed:20463662}. Note=Translocates to the plasma membrane upon EGF stimulation (By similarity). Shuttles between the cytoplasm and the nucleus, depending on the cell cycle stage, with highest amounts detected in the nucleus during the G0/G1phase (By similarity). {ECO:0000250|UniProtKB:Q96PE3}.
uniprot
proteins