Pias3
entrez
83614
canonical
uniprot
O70260
canonical
ensembl
ENSRNOG00000021218
resolver
ensembl
ENSRNOG00060012718
resolver
ensembl
ENSRNOG00065032344
resolver
ensp
ENSRNOP00000028814
resolver
ensp
ENSRNOP00000111478
resolver
ensp
ENSRNOP00060017084
resolver
ensp
ENSRNOP00065045853
resolver
enst
ENSRNOT00000028814
resolver
enst
ENSRNOT00000172880
resolver
enst
ENSRNOT00060021616
resolver
enst
ENSRNOT00065055688
resolver
genesymbol
Pias3
resolver
uniprot
A0A8L2QFJ6
resolver
uniprot_entry
A0A8L2QFJ6_RAT
resolver
uniprot_entry
PIAS3_RAT
resolver
amino_acid_sequence
MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPPGTSPVGSPSPLASIPPTLLTPGTLLGPKREVDMHPPLPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQLQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILNSCSDCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQEGNQSENKKRVEVIDLTIESSSDEEDLPPTKKHCPVTSAAIPALPGSKGALTSGHQPSSVLRSPAMGTLGSDFLSSLPLHEYPPAFPLGADIQGLDLFSFLQTESQHYSPSVITSLDEQDTLGHFFQFRGTPPHFLGPLAPTLGSSHRSATPAPAPGRVSSIVAPGSSLREGHGGPLPSGPSLTGCRSDVISLD
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
function
FUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1. Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity). {ECO:0000250|UniProtKB:O54714, ECO:0000250|UniProtKB:Q9Y6X2}.
uniprot
proteins
mass_dalton
68364
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein sumoylation.
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000250}.
uniprot
proteins
protein_family
PIAS family
uniprot
proteins
pubmed
11709556
uniprot
proteins
pubmed
11997457
uniprot
proteins
pubmed
9565597
uniprot
proteins
sequence_length
628
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O54714}. Nucleus {ECO:0000269|PubMed:9565597}. Nucleus speckle {ECO:0000250|UniProtKB:O54714}. Note=Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules. {ECO:0000250|UniProtKB:O54714}.
uniprot
proteins