RPS2
entrez
6187
canonical
uniprot
P15880
canonical
ensembl
ENSG00000140988
resolver
ensembl
ENSG00000291931
resolver
ensp
ENSP00000341885
resolver
ensp
ENSP00000517575
resolver
ensp
ENSP00000542286
resolver
ensp
ENSP00000542288
resolver
ensp
ENSP00000542292
resolver
ensp
ENSP00000542293
resolver
ensp
ENSP00000599982
resolver
ensp
ENSP00000599984
resolver
enst
ENST00000343262
resolver
enst
ENST00000709238
resolver
enst
ENST00000872227
resolver
enst
ENST00000872229
resolver
enst
ENST00000872233
resolver
enst
ENST00000872234
resolver
enst
ENST00000929923
resolver
enst
ENST00000929925
resolver
genesymbol
RPS2
resolver
genesymbol_syn
RPS4
resolver
hgnc
HGNC:10404
resolver
uniprot
B2R5G0
resolver
uniprot
D3DU82
resolver
uniprot
Q3MIB1
resolver
uniprot_entry
RS2_HUMAN
resolver
uniprot_sec
B2R5G0
resolver
uniprot_sec
D3DU82
resolver
uniprot_sec
Q3MIB1
resolver
amino_acid_sequence
MADDAGAAGGPGGPGGPGMGNRGGFRGGFGSGIRGRGRGRGRGRGRGRGARGGKAEDKEWMPVTKLGRLVKDMKIKSLEEIYLFSLPIKESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLWKETVFTKSPYQEFTDHLVKTHTRVSVQRTQAPAVATT
uniprot
proteins
function
FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:23636399). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:23636399). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399). Plays a role in the assembly and function of the 40S ribosomal subunit (By similarity). Mutations in this protein affects the control of translational fidelity (By similarity). Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). {ECO:0000250|UniProtKB:P25443, ECO:0000269|PubMed:23636399}.
uniprot
proteins
mass_dalton
31324
uniprot
proteins
mutagenesis
MUTAGEN 54..58; /note="KAEDK->RAEDR: Abolished ubiquitination and degradation by RNF10."; /evidence="ECO:0000269|PubMed:34469731"; MUTAGEN 58; /note="K->R: Does not affect readthrough on the poly(A)-stall sequences; when associated with R-275."; /evidence="ECO:0000269|PubMed:28132843"; MUTAGEN 275; /note="K->R: Does not affect readthrough on the poly(A)-stall sequences; when associated with R-58."; /evidence="ECO:0000269|PubMed:28132843
uniprot
proteins
post_translational_modification
PTM: Citrullinated by PADI4 in the Arg/Gly-rich region. {ECO:0000269|PubMed:21584310}.; PTM: Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region. {ECO:0000269|PubMed:15473865}.; PTM: Monoubiquitinated at Lys-54 and Lys-58 by RNF10 when a ribosome has stalled during translation, leading to its degradation by the proteasome (PubMed:34348161, PubMed:34469731, PubMed:39947182, PubMed:39947183). Monoubiquitination at Lys-54 and Lys-58 promotes interaction with RIOK3 (PubMed:39947182, PubMed:39947183). Deubiquitinated at Lys-54 and Lys-58 by USP10, preventing degradation by the proteasome and promoting 40S ribosome subunit recycling following ribosome dissociation (PubMed:31981475). {ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:39947182, ECO:0000269|PubMed:39947183}.
uniprot
proteins
protein_family
Universal ribosomal protein uS5 family
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15473865
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21584310
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
2308862
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23636399
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24524803
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27697862
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28132843
uniprot
proteins
pubmed
30530495
uniprot
proteins
pubmed
31981475
uniprot
proteins
pubmed
32011234
uniprot
proteins
pubmed
33245768
uniprot
proteins
pubmed
34348161
uniprot
proteins
pubmed
34469731
uniprot
proteins
pubmed
39947182
uniprot
proteins
pubmed
39947183
uniprot
proteins
pubmed
8706699
uniprot
proteins
sequence_length
293
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:30530495}. Nucleus, nucleolus {ECO:0000269|PubMed:30530495}. Note=Probably localized to nucleolus and cytoplasm in complex with ZNF277. {ECO:0000269|PubMed:30530495}.
uniprot
proteins