Prune1
entrez
310664
canonical
uniprot
Q6AYG3
canonical
ensembl
ENSRNOG00000021120
resolver
ensembl
ENSRNOG00060012810
resolver
ensembl
ENSRNOG00065022484
resolver
ensp
ENSRNOP00000028677
resolver
ensp
ENSRNOP00060017273
resolver
ensp
ENSRNOP00065031117
resolver
enst
ENSRNOT00000028677
resolver
enst
ENSRNOT00060021827
resolver
enst
ENSRNOT00065038407
resolver
genesymbol
Prune1
resolver
genesymbol_syn
Prune
resolver
uniprot_entry
PRUN1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Phosphodiesterase activity is activated by magnesium ions and inhibited by manganese ions. Phosphodiesterase activity is inhibited by dipyridamole, moderately sensitive to IBMX and inhibited by vinpocetine. {ECO:0000250|UniProtKB:Q86TP1}.
uniprot
proteins
amino_acid_sequence
MEDYLQDCRAALQESRPLHVVLGNEACDLDSMVSALALAFYLTKTSEAEDIFIPVLNIKRSELPLRGDNVFFLQEVKIAESALIFRDEIDLLALHQAGQLTLILVDHHMLPKSDAALEEAVAEVLDHRPIEQKYCPPCHVSVELVGSCATLVAERILQGAPETLDRQTAALLHGTIILDCVNMDAKIGKATLKDNEYVEKLEALFPDLPKRKDIFDSLQKAKFDVSGLTTEQMLRKDQKTIYRQGTKVAVSAVYMDLEAFLQRSGLLSDLSAFCQDHSYDALVAMAIFFNTHNEPVRQLAIFCPHEALRMTICGVLEQSTSPALKLTPIPSISAHLQAYLQGNTQVSRKKLLPVLQEALSAYLDSMRTPAGQLEAALGMSREQADKELDKASNSLIAGLSQDDEDPPLPPTPMNSLVDECPLDQGLPKLSAEAVFEKCSQISLSQSTRACPSNK
uniprot
proteins
ec_number
3.6.1.14
uniprot
proteins
ec_number
3.6.1.25
uniprot
proteins
function
FUNCTION: Exopolyphosphatase that catalyzes the hydrolysis of inorganic polyphosphates, with preference for short-chain substrates, as well as nucleoside 5'-tetraphosphates, releasing terminal phosphate residues. Also exhibits phosphodiesterase activity toward cyclic nucleotides, hydrolyzing cAMP and cGMP to their corresponding 5'-monophosphates. Requires divalent metal ions for activity. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization. {ECO:0000250|UniProtKB:Q86TP1}.
uniprot
proteins
mass_dalton
49998
uniprot
proteins
protein_family
PPase class C family
uniprot
proteins
protein_family
Prune subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
454
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}.
uniprot
proteins