Spp1
entrez
25353
canonical
uniprot
P08721
canonical
ensembl
ENSRNOG00000043451
resolver
ensembl
ENSRNOG00065012697
resolver
ensp
ENSRNOP00000062358
resolver
ensp
ENSRNOP00065015929
resolver
enst
ENSRNOT00000067875
resolver
enst
ENSRNOT00065020692
resolver
genesymbol
Spp1
resolver
genesymbol_syn
2b7
resolver
genesymbol_syn
Spp-1
resolver
uniprot_entry
OSTP_RAT
resolver
amino_acid_sequence
MRLAVVCFCLFGLASCLPVKVAEFGSSEEKAHYSKHSDAVATWLKPDPSQKQNLLAPQNSVSSEETDDFKQETLPSNSNESHDHMDDDDDDDDDGDHAESEDSVNSDESDESHHSDESDESFTASTQADVLTPIAPTVDVPDGRGDSLAYGLRSKSRSFPVSDEQYPDATDEDLTSRMKSQESDEAIKVIPVAQRLSVPSDQDSNGKTSHESSQLDEPSVETHSLEQSKEYKQRASHESTEQSDAIDSAEKPDAIDSAERSDAIDSQASSKASLEHQSHEFHSHEDKLVLDPKSKEDDRYLKFRISHELESSSSEVN
uniprot
proteins
function
FUNCTION: Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}.
uniprot
proteins
mass_dalton
34963
uniprot
proteins
post_translational_modification
PTM: Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif (By similarity). The phosphorylated form inhibits hydroxyapatite crystallization. Dephosphorylation via a mechanism involving ALPL/TNAP promotes hydroxyapatite crystallization (By similarity). {ECO:0000250|UniProtKB:P10451, ECO:0000250|UniProtKB:P10923}.; PTM: O-glycosylated. {ECO:0000250|UniProtKB:P10451}.; PTM: Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers, increasing its collagen binding properties. {ECO:0000250|UniProtKB:P31096}.
uniprot
proteins
protein_family
Osteopontin family
uniprot
proteins
pubmed
1429723
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2736258
uniprot
proteins
pubmed
3024151
uniprot
proteins
pubmed
3167835
uniprot
proteins
pubmed
3469201
uniprot
proteins
pubmed
8408622
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P10451}.
uniprot
proteins