Fstl3
entrez
83554
canonical
uniprot
Q9EQC7
canonical
ensembl
ENSMUSG00000020325
resolver
ensp
ENSMUSP00000020575
resolver
enst
ENSMUST00000020575
resolver
genesymbol
Fstl3
resolver
genesymbol_syn
Flrg
resolver
uniprot
Q542M9
resolver
uniprot_entry
FSTL3_MOUSE
resolver
uniprot_entry
Q542M9_MOUSE
resolver
amino_acid_sequence
MRSGALWPLLWGALVWTVGSVGAVMGSEDSVPGGVCWLQQGREATCSLVLKTRVSREECCASGNINTAWSNFTHPGNKISLLGFLGLVHCLPCKDSCDGVECGPGKACRMLGGRPHCECVPNCEGLPAGFQVCGSDGATYRDECELRTARCRGHPDLRVMYRGRCQKSCAQVVCPRPQSCLVDQTGSAHCVVCRAAPCPVPSNPGQELCGNNNVTYISSCHLRQATCFLGRSIGVRHPGICTGGPKVPAEEEENFV
uniprot
proteins
function
FUNCTION: The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such as activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
27271
uniprot
proteins
pubmed
11010968
uniprot
proteins
pubmed
11459787
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17878677
uniprot
proteins
sequence_length
256
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins