RNF135
entrez
84282
canonical
uniprot
Q8IUD6
canonical
ensembl
ENSG00000181481
resolver
ensembl
ENSG00000291712
resolver
ensp
ENSP00000323693
resolver
ensp
ENSP00000328340
resolver
ensp
ENSP00000440470
resolver
genesymbol
RNF135
resolver
hgnc
HGNC:21158
resolver
uniprot
A0AVM5
resolver
uniprot
B2R7G9
resolver
uniprot
B3KV69
resolver
uniprot
B6ZLM5
resolver
uniprot
F5GX60
resolver
uniprot
Q9BSE9
resolver
uniprot_entry
B3KV69_HUMAN
resolver
uniprot_entry
RN135_HUMAN
resolver
uniprot_sec
A0AVM5
resolver
uniprot_sec
B2R7G9
resolver
uniprot_sec
B6ZLM5
resolver
uniprot_sec
F5GX60
resolver
uniprot_sec
Q9BSE9
resolver
amino_acid_sequence
MAGLGLGSAVPVWLAEDDLGCIICQGLLDWPATLPCGHSFCRHCLEALWGARDARRWACPTCRQGAAQQPHLRKNTLLQDLADKYRRAAREIQAGSDPAHCPCPGSSSLSSAAARPRRRPELQRVAVEKSITEVAQELTELVEHLVDIVRSLQNQRPLSESGPDNELSILGKAFSSGVDLSMASPKLVTSDTAAGKIRDILHDLEEIQEKLQESVTWKEAPEAQMQGELLEAPSSSSCPLPDQSHPALRRASRFAQWAIHPTFNLKSLSCSLEVSKDSRTVTVSHRPQPYRWSCERFSTSQVLCSQALSSGKHYWEVDTRNCSHWAVGVASWEMSRDQVLGRTMDSCCVEWKGTSQLSAWHMVKETVLGSDRPGVVGIWLNLEEGKLAFYSVDNQEKLLYECTISASSPLYPAFWLYGLHPGNYLIIKQVKV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:19017631, PubMed:19484123, PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531). Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway (PubMed:19017631, PubMed:21147464, PubMed:28469175, PubMed:31006531). Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway (PubMed:31006531). This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (Probable). Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway (PubMed:28469175, PubMed:31006531). {ECO:0000269|PubMed:19017631, ECO:0000269|PubMed:19484123, ECO:0000269|PubMed:21147464, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:31006531, ECO:0000305|PubMed:31006531}.
uniprot
proteins
mass_dalton
47888
uniprot
proteins
mutagenesis
MUTAGEN 16..18; /note="EDD->AAA: Prevents degradation by hepatitis C virus NS3/NS4A."; /evidence="ECO:0000269|PubMed:23950712"; MUTAGEN 21; /note="C->A: Loss of function in RIG-I signaling pathway; when associated with A-24."; /evidence="ECO:0000269|PubMed:28469175"; MUTAGEN 24; /note="C->A: Loss of function in RIG-I signaling pathway; when associated with A-21."; /evidence="ECO:0000269|PubMed:28469175
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:31006531}.
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Cleaved and inactivated by hepatitis C virus NS3/NS4A. {ECO:0000269|PubMed:23950712}.
uniprot
proteins
pubmed
12696059
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15334068
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17632510
uniprot
proteins
pubmed
19017631
uniprot
proteins
pubmed
19291764
uniprot
proteins
pubmed
19484123
uniprot
proteins
pubmed
19881509
uniprot
proteins
pubmed
21147464
uniprot
proteins
pubmed
23950712
uniprot
proteins
pubmed
28469175
uniprot
proteins
pubmed
31006531
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19484123, ECO:0000269|PubMed:23950712}. Cytoplasm, Stress granule {ECO:0000269|PubMed:23950712}.
uniprot
proteins