TNFSF14
entrez
8740
canonical
uniprot
O43557
canonical
ensembl
ENSG00000125735
resolver
ensp
ENSP00000245912
resolver
ensp
ENSP00000469049
resolver
ensp
ENSP00000502837
resolver
genesymbol
TNFSF14
resolver
genesymbol_syn
HVEML
resolver
genesymbol_syn
LIGHT
resolver
hgnc
HGNC:11930
resolver
uniprot
A8K7M2
resolver
uniprot
C9J5H4
resolver
uniprot
O75476
resolver
uniprot
Q6FHA1
resolver
uniprot
Q8WVF8
resolver
uniprot
Q96LD2
resolver
uniprot_entry
TNF14_HUMAN
resolver
uniprot_sec
A8K7M2
resolver
uniprot_sec
C9J5H4
resolver
uniprot_sec
O75476
resolver
uniprot_sec
Q6FHA1
resolver
uniprot_sec
Q8WVF8
resolver
uniprot_sec
Q96LD2
resolver
amino_acid_sequence
MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQLHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGLAFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
uniprot
proteins
function
FUNCTION: Cytokine that binds to TNFRSF3/LTB and TNFRSF14/HVEM and plays major roles in immune system regulation (PubMed:10754304, PubMed:9462508). Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (PubMed:10754304). Binds to the decoy receptor TNFRSF6B thereby disrupts the activation signal initiated by TNFSF14, resulting in reduced T-cell activation (PubMed:25087510). {ECO:0000269|PubMed:10754304, ECO:0000269|PubMed:25087510, ECO:0000269|PubMed:9462508}.
uniprot
proteins
mass_dalton
26350
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|Ref.10}.; PTM: The soluble form of isoform 1 derives from the membrane form by proteolytic processing. {ECO:0000269|PubMed:11673523}.
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
10754304
uniprot
proteins
pubmed
11673523
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
25087510
uniprot
proteins
pubmed
9462508
uniprot
proteins
pubmed
9765287
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 14, membrane form]: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 14, soluble form]: Secreted.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins