MIXL1
entrez
83881
canonical
uniprot
Q9H2W2
canonical
ensembl
ENSG00000185155
resolver
ensp
ENSP00000355775
resolver
ensp
ENSP00000442439
resolver
genesymbol
MIXL1
resolver
genesymbol_syn
MIXL
resolver
hgnc
HGNC:13363
resolver
uniprot
B7ZLF9
resolver
uniprot_entry
MIXL1_HUMAN
resolver
uniprot_sec
B7ZLF9
resolver
amino_acid_sequence
MATAESRALQFAEGAAFPAYRAPHAGGALLPPPSPAAALLPAPPAGPGPATFAGFLGRDPGPAPPPPASLGSPAPPKGAAAPSASQRRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIQVWFQNRRAKSRRQSGKSFQPLARPEIILNHCAPGTETKCLKPQLPLEVDVNCLPEPNGVGGGISDSSSQGQNFETCSPLSEDIGSKLDSWEEHIFSAFGNF
uniprot
proteins
function
FUNCTION: Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
24659
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at multiple sites. {ECO:0000269|PubMed:17224082}.
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
11084649
uniprot
proteins
pubmed
12070013
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16433620
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17224082
uniprot
proteins
pubmed
17303500
uniprot
proteins
sequence_length
232
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12070013, ECO:0000269|PubMed:17303500}.
uniprot
proteins