PEG10
entrez
23089
canonical
uniprot
Q86TG7
canonical
ensembl
ENSG00000242265
resolver
ensp
ENSP00000417587
resolver
ensp
ENSP00000418944
resolver
ensp
ENSP00000482653
resolver
enst
ENST00000615790
resolver
genesymbol
PEG10
resolver
genesymbol_syn
EDR
resolver
genesymbol_syn
KIAA1051e
resolver
genesymbol_syn
MAR2
resolver
genesymbol_syn
MART2
resolver
genesymbol_syn
MEF3L1
resolver
genesymbol_syn
RGAG3
resolver
hgnc
HGNC:14005
resolver
uniprot
A0A087WZG9
resolver
uniprot
B4DSP0
resolver
uniprot
Q96A68
resolver
uniprot
Q9UPV1
resolver
uniprot_entry
A0A087WZG9_HUMAN
resolver
uniprot_entry
PEG10_HUMAN
resolver
uniprot_sec
B4DSP0
resolver
uniprot_sec
Q96A68
resolver
uniprot_sec
Q9UPV1
resolver
amino_acid_sequence
MTERRRDELSEEINNLREKVMKQSEENNNLQSQVQKLTEENTTLREQVEPTPEDEDDDIELRGAAAAAAPPPPIEEECPEDLPEKFDGNPDMLAPFMAQCQIFMEKSTRDFSVDRVRVCFVTSMMTGRAARWASAKLERSHYLMHNYPAFMMEMKHVFEDPQRREVAKRKIRRLRQGMGSVIDYSNAFQMIAQDLDWNEPALIDQYHEGLSDHIQEELSHLEVAKSLSALIGQCIHIERRLARAAAARKPRSPPRALVLPHIASHHQVDPTEPVGGARMRLTQEEKERRRKLNLCLYCGTGGHYADNCPAKASKSSPAGKLPGPAVEGPSATGPEIIRSPQDDASSPHLQVMLQIHLPGRHTLFVRAMIDSGASGNFIDHEYVAQNGIPLRIKDWPILVEAIDGRPIASGPVVHETHDLIVDLGDHREVLSFDVTQSPFFPVVLGVRWLSTHDPNITWSTRSIVFDSEYCRYHCRMYSPIPPSLPPPAPQPPLYYPVDGYRVYQPVRYYYVQNVYTPVDEHVYPDHRLVDPHIEMIPGAHSIPSGHVYSLSEPEMAALRDFVARNVKDGLITPTIAPNGAQVLQVKRGWKLQVSYDCRAPNNFTIQNQYPRLSIPNLEDQAHLATYTEFVPQIPGYQTYPTYAAYPTYPVGFAWYPVGRDGQGRSLYVPVMITWNPHWYRQPPVPQYPPPQPPPPPPPPPPPPSYSTL
uniprot
proteins
function
FUNCTION: Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidence is however required to confirm this result (By similarity). {ECO:0000250|UniProtKB:Q7TN75, ECO:0000269|PubMed:12810624, ECO:0000269|PubMed:15611116, ECO:0000269|PubMed:16423995, ECO:0000269|PubMed:26235627, ECO:0000269|PubMed:28193232, ECO:0000269|PubMed:30094509, ECO:0000269|PubMed:34413232}.
uniprot
proteins
mass_dalton
80173
uniprot
proteins
mutagenesis
MUTAGEN 370; /note="D->A: Inhibits proteolytic cleavage."; /evidence="ECO:0000269|PubMed:17942406
uniprot
proteins
post_translational_modification
PTM: [Isoform 1]: Undergoes proteolytic cleavage. {ECO:0000269|PubMed:17942406}.
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
11318613
uniprot
proteins
pubmed
12620933
uniprot
proteins
pubmed
12810624
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15611116
uniprot
proteins
pubmed
16423995
uniprot
proteins
pubmed
17050006
uniprot
proteins
pubmed
17369855
uniprot
proteins
pubmed
17621626
uniprot
proteins
pubmed
17942406
uniprot
proteins
pubmed
18625225
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20084274
uniprot
proteins
pubmed
20362226
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21677654
uniprot
proteins
pubmed
26235627
uniprot
proteins
pubmed
28193232
uniprot
proteins
pubmed
28992046
uniprot
proteins
pubmed
30094509
uniprot
proteins
pubmed
34357660
uniprot
proteins
pubmed
34413232
uniprot
proteins
sequence_length
708
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Extracellular vesicle membrane {ECO:0000269|PubMed:34413232}. Cytoplasm {ECO:0000269|PubMed:12810624, ECO:0000269|PubMed:15611116, ECO:0000269|PubMed:16423995, ECO:0000269|PubMed:17621626}. Nucleus {ECO:0000269|PubMed:12810624}. Note=Forms virion-like extracellular vesicles that are released from cells (PubMed:34413232). Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line (PubMed:12810624). {ECO:0000269|PubMed:12810624, ECO:0000269|PubMed:34413232}.
uniprot
proteins