NCLN
entrez
56926
canonical
uniprot
Q969V3
canonical
ensembl
ENSG00000125912
resolver
ensp
ENSP00000246117
resolver
ensp
ENSP00000532218
resolver
genesymbol
NCLN
resolver
hgnc
HGNC:26923
resolver
uniprot
D6W613
resolver
uniprot
O75252
resolver
uniprot
Q6FI60
resolver
uniprot
Q6ZMB7
resolver
uniprot
Q8TAT7
resolver
uniprot
Q96H48
resolver
uniprot
Q96IS7
resolver
uniprot
Q9BQH9
resolver
uniprot
Q9BTX4
resolver
uniprot
Q9NPP2
resolver
uniprot_entry
NCLN_HUMAN
resolver
uniprot_sec
D6W613
resolver
uniprot_sec
O75252
resolver
uniprot_sec
Q6FI60
resolver
uniprot_sec
Q6ZMB7
resolver
uniprot_sec
Q8TAT7
resolver
uniprot_sec
Q96H48
resolver
uniprot_sec
Q96IS7
resolver
uniprot_sec
Q9BQH9
resolver
uniprot_sec
Q9BTX4
resolver
uniprot_sec
Q9NPP2
resolver
amino_acid_sequence
MLEEAGEVLENMLKASCLPLGFIVFLPAVLLLVAPPLPAADAAHEFTVYRMQQYDLQGQPYGTRNAVLNTEARTMAAEVLSRRCVLMRLLDFSYEQYQKALRQSAGAVVIILPRAMAAVPQDVVRQFMEIEPEMLAMETAVPVYFAVEDEALLSIYKQTQAASASQGSASAAEVLLRTATANGFQMVTSGVQSKAVSDWLIASVEGRLTGLGGEDLPTIVIVAHYDAFGVAPWLSLGADSNGSGVSVLLELARLFSRLYTYKRTHAAYNLLFFASGGGKFNYQGTKRWLEDNLDHTDSSLLQDNVAFVLCLDTVGRGSSLHLHVSKPPREGTLQHAFLRELETVAAHQFPEVRFSMVHKRINLAEDVLAWEHERFAIRRLPAFTLSHLESHRDGQRSSIMDVRSRVDSKTLTRNTRIIAEALTRVIYNLTEKGTPPDMPVFTEQMQIQQEQLDSVMDWLTNQPRAAQLVDKDSTFLSTLEHHLSRYLKDVKQHHVKADKRDPEFVFYDQLKQVMNAYRVKPAVFDLLLAVGIAAYLGMAYVAVQHFSLLYKTVQRLLVKAKTQ
uniprot
proteins
function
FUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity). {ECO:0000250|UniProtKB:Q6NZ07, ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}.
uniprot
proteins
mass_dalton
62974
uniprot
proteins
protein_family
Nicastrin family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15257293
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20538592
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
32820719
uniprot
proteins
pubmed
36261522
uniprot
proteins
sequence_length
563
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15257293, ECO:0000269|PubMed:20538592}; Single-pass membrane protein {ECO:0000269|PubMed:15257293, ECO:0000269|PubMed:20538592}.
uniprot
proteins
transmembrane_region
TRANSMEM 523..543; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins