St6galnac3
entrez
29758
canonical
uniprot
Q64686
canonical
ensembl
ENSRNOG00000056894
resolver
ensembl
ENSRNOG00055027884
resolver
ensembl
ENSRNOG00060001550
resolver
ensembl
ENSRNOG00065012623
resolver
ensp
ENSRNOP00000073209
resolver
ensp
ENSRNOP00055039682
resolver
ensp
ENSRNOP00060001510
resolver
ensp
ENSRNOP00065015803
resolver
enst
ENSRNOT00000082253
resolver
enst
ENSRNOT00055048262
resolver
enst
ENSRNOT00060002333
resolver
enst
ENSRNOT00065020550
resolver
genesymbol
St6galnac3
resolver
genesymbol_syn
Siat7c
resolver
uniprot
A0A096MK04
resolver
uniprot_entry
A0A096MK04_RAT
resolver
uniprot_entry
SIA7C_RAT
resolver
amino_acid_sequence
MACILKRKPALAVSFIALCILLLAMRLANDVTFPLLLNCFGQPKTKWIPLSYTLRQPLQTHYGYINVRTQEPLQLNCNHCAVVSNSGQMVGQKVGEEIDRASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASTTIYVIWGPFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQRMTYCDGVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYGMINETYCTTEGYRKVPYHYYEQGKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNWTVS
uniprot
proteins
ec_number
2.4.3.7
uniprot
proteins
function
FUNCTION: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:8631773). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (By similarity). {ECO:0000250|UniProtKB:Q8NDV1, ECO:0000250|UniProtKB:Q9QYJ1, ECO:0000269|PubMed:8631773}.
uniprot
proteins
mass_dalton
35150
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000305|PubMed:8631773}.; PATHWAY: Glycolipid biosynthesis. {ECO:0000305|PubMed:8631773}.
uniprot
proteins
protein_family
Glycosyltransferase 29 family
uniprot
proteins
pubmed
8631773
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins