Abcg4
entrez
300664
canonical
uniprot
D3ZCM3
canonical
ensembl
ENSRNOG00000008862
resolver
ensp
ENSRNOP00000012534
resolver
genesymbol
Abcg4
resolver
uniprot_entry
ABCG4_RAT
resolver
amino_acid_sequence
MAEKALEAVGCGLGPGAVAMAVALEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRDLRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAHGGRTVICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCTMAEKKSSPEKNEVPAHCPTCPPELDPIESHTFATSTLTQFCILFRRTFLSILRDTVLTHLRFMSHVLIGVLIGLLYLHIGDDASKVFNNTGFLFFSMLFLMFAALMPTVLTCELICLAKMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALSIATALVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGLILTIYGMERGHLTCLEDHCPFRDPQIILHELDVEEAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSER
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL) (By similarity). May play an important role in the removal of amyloid-beta peptides from brain,in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity). Induces apoptosis in various cells (By similarity). {ECO:0000250|UniProtKB:Q91WA9, ECO:0000250|UniProtKB:Q9H172}.
uniprot
proteins
mass_dalton
72491
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCG family
uniprot
proteins
protein_family
Eye pigment precursor importer (TC 3.A.1.204) subfamily
uniprot
proteins
pubmed
12183068
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
21972082
uniprot
proteins
sequence_length
650
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H172}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q91WA9}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:Q91WA9}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 394..414; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 424..444; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 477..497; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 508..528; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 537..557; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 622..642; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins