Q9QZW9
uniprot
Q9QZW9
canonical
amino_acid_sequence
MEKSKNFRIDALLAVDPPRAASTQSAPLALVTSLATTVSGPGRGGSGGGGTSSGASRSCSPASSEATAAPGDRLRAESPSPPRLLAAHCALLPKPGFLGAGGGGGAAGGPGTPHHHAHPGAAAAAAAAAAAAAAGGLALGLHPGGAQGGAGLPAQAALYGHPVYSYSAAAAAAALAGQHPALSYSYPQVQGAHPAHPADPIKLGASTFQLDQWLRASTAGMILPKMPDFSCEAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKAKEQAAQEAEKQKGGGGGTGKGGSEEKTEEELMGPPVSGDKASGRRLRDLRDSDPDEDEDDEEEDNFPYSNGAGAHAASSDCSSEDDSPPPRLGGPGHQPLPQ
uniprot
proteins
function
FUNCTION: Transcription factor (PubMed:18539116). Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (PubMed:18539116). Plays a role in establishing motor neuron identity, in concert with LIM domain transcription cofactor LMO4 (PubMed:18539116). Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking interactions of ISL1-LHX3 complexes with regulatory elements (PubMed:18539116). Involved in pancreas development and function; may play a role in pancreatic cell fate specification (PubMed:10471502). {ECO:0000269|PubMed:10471502, ECO:0000269|PubMed:18539116}.
uniprot
proteins
mass_dalton
41331
uniprot
proteins
pubmed
10471502
uniprot
proteins
pubmed
18539116
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
404
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:10471502}.
uniprot
proteins