Bmi1
entrez
12151
canonical
uniprot
P25916
canonical
ensembl
ENSMUSG00000026739
resolver
ensp
ENSMUSP00000028071
resolver
ensp
ENSMUSP00000110300
resolver
ensp
ENSMUSP00000176531
resolver
enst
ENSMUST00000028071
resolver
enst
ENSMUST00000051929
resolver
genesymbol
Bmi1
resolver
genesymbol_syn
Bmi-1
resolver
genesymbol_syn
Pcgf4
resolver
uniprot
Q2LC58
resolver
uniprot_entry
BMI1_MOUSE
resolver
uniprot_entry
Q2LC58_MOUSE
resolver
amino_acid_sequence
MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQVHKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAAHPSADAANGSNEDRGEVADEEKRIITDDEIISLSIEFFDQSRLDRKVNKEKPKEEVNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNGPLPLKYRVRPTCKRMKMSHQRDGLTNAGELESDSGSDKANSPAGGVPSTSSCLPSPSTPVQSPHPQFPHISSTMNGTSNSPSANHQSSFASRPRKSSLNGSSATSSG
uniprot
proteins
function
FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity). {ECO:0000250|UniProtKB:P35226, ECO:0000269|PubMed:16710298}.
uniprot
proteins
mass_dalton
36708
uniprot
proteins
post_translational_modification
PTM: May be polyubiquitinated; which does not lead to proteasomal degradation (By similarity). Monoubiquitinated. {ECO:0000250, ECO:0000269|PubMed:16710298}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16359901
uniprot
proteins
pubmed
16710298
uniprot
proteins
pubmed
1904008
uniprot
proteins
pubmed
1904009
uniprot
proteins
pubmed
20808772
uniprot
proteins
sequence_length
324
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P35226}. Cytoplasm {ECO:0000250|UniProtKB:P35226}.
uniprot
proteins