Srsf3
entrez
20383
canonical
uniprot
P84104
canonical
ensembl
ENSMUSG00000071172
resolver
ensp
ENSMUSP00000117045
resolver
genesymbol
Srsf3
resolver
genesymbol_syn
Sfrs3
resolver
genesymbol_syn
Srp20
resolver
genesymbol_syn
X16
resolver
uniprot
O08831
resolver
uniprot
P23152
resolver
uniprot
Q564E9
resolver
uniprot_entry
SRSF3_MOUSE
resolver
uniprot_sec
O08831
resolver
uniprot_sec
P23152
resolver
uniprot_sec
Q564E9
resolver
amino_acid_sequence
MHRDSCPLDCKVYVGNLGNNGNKTELERAFGYYGPLRSVWVARNPPGFAFVEFEDPRDAADAVRELDGRTLCGCRVRVELSNGEKRSRNRGPPPSWGRRPRDDYRRRSPPPRRRSPRRRSFSRSRSRSLSRDRRRERSLSRERNHKPSRSFSRSRSRSRSNERK
uniprot
proteins
function
FUNCTION: Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. {ECO:0000250|UniProtKB:P84103}.
uniprot
proteins
mass_dalton
19330
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain. {ECO:0000269|PubMed:9307018}.
uniprot
proteins
protein_family
Splicing factor SR family
uniprot
proteins
pubmed
10823932
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
2030943
uniprot
proteins
pubmed
29799838
uniprot
proteins
pubmed
9154810
uniprot
proteins
pubmed
9307018
uniprot
proteins
sequence_length
164
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P84103}. Nucleus speckle {ECO:0000250|UniProtKB:P84103}. Cytoplasm {ECO:0000250|UniProtKB:P84103}. Note=Recruited to nuclear speckles following interaction with YTHDC1. {ECO:0000250|UniProtKB:P84103}.
uniprot
proteins