Dkk2
entrez
56811
canonical
uniprot
Q9QYZ8
canonical
ensembl
ENSMUSG00000028031
resolver
ensp
ENSMUSP00000029665
resolver
ensp
ENSMUSP00000299911
resolver
enst
ENSMUST00000029665
resolver
genesymbol
Dkk2
resolver
uniprot
Q8BFW0
resolver
uniprot_entry
DKK2_MOUSE
resolver
uniprot_sec
Q8BFW0
resolver
amino_acid_sequence
MAALMRVKDSSRCLLLLAAVLMVESSQLGSSRAKLNSIKSSLGGETPAQSANRSAGMNQGLAFGGSKKGKSLGQAYPCSSDKECEVGRYCHSPHQGSSACMLCRRKKKRCHRDGMCCPGTRCNNGICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDLGWQNLGRPHSKMPHIKGHEGDPCLRSSDCIDGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI
uniprot
proteins
function
FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. {ECO:0000269|PubMed:18524778}.
uniprot
proteins
mass_dalton
28432
uniprot
proteins
post_translational_modification
PTM: May be proteolytically processed by a furin-like protease.
uniprot
proteins
protein_family
Dickkopf family
uniprot
proteins
pubmed
10495270
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17143291
uniprot
proteins
pubmed
18524778
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27550540
uniprot
proteins
pubmed
27713059
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins