ATP2B4
entrez
493
canonical
uniprot
P23634
canonical
ensembl
ENSG00000058668
resolver
ensp
ENSP00000340930
resolver
ensp
ENSP00000350310
resolver
ensp
ENSP00000785470
resolver
genesymbol
ATP2B4
resolver
genesymbol_syn
ATP2B2
resolver
genesymbol_syn
MXRA1
resolver
hgnc
HGNC:817
resolver
uniprot
B1APW5
resolver
uniprot
B1APW6
resolver
uniprot
Q13450
resolver
uniprot
Q13452
resolver
uniprot
Q13455
resolver
uniprot
Q16817
resolver
uniprot
Q7Z3S1
resolver
uniprot_entry
AT2B4_HUMAN
resolver
uniprot_sec
B1APW5
resolver
uniprot_sec
B1APW6
resolver
uniprot_sec
Q13450
resolver
uniprot_sec
Q13452
resolver
uniprot_sec
Q13455
resolver
uniprot_sec
Q16817
resolver
uniprot_sec
Q7Z3S1
resolver
activity_regulation
ACTIVITY REGULATION: Activated by calcium/calmodulin. {ECO:0000269|PubMed:8530416}.
uniprot
proteins
amino_acid_sequence
MTNPSDRVLPANSMAESREGDFGCTVMELRKLMELRSRDALTQINVHYGGVQNLCSRLKTSPVEGLSGNPADLEKRRQVFGHNVIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPAGEENELCGQVATTPEDENEAQAGWIEGAAILFSVIIVVLVTAFNDWSKEKQFRGLQCRIEQEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIILTLLGVNEDDEGEKKKKGKKQGVPENRNKAKTQDGVALEIQPLNSQEGIDNEEKDKKAVKVPKKEKSVLQGKLTRLAVQIGKAGLLMSALTVFILILYFVIDNFVINRRPWLPECTPIYIQYFVKFFIIGITVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGIHYRQIPSPDVFLPKVLDLIVNGISINSAYTSKILPPEKEGGLPRQVGNKTECALLGFVTDLKQDYQAVRNEVPEEKLYKVYTFNSVRKSMSTVIRNPNGGFRMYSKGASEIILRKCNRILDRKGEAVPFKNKDRDDMVRTVIEPMACDGLRTICIAYRDFDDTEPSWDNENEILTELTCIAVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNINTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTVGEHRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLKRRPYGRNKPLISRTMMKNILGHAFYQLIVIFILVFAGEKFFDIDSGRKAPLHSPPSQHYTIVFNTFVLMQLFNEINSRKIHGEKNVFSGIYRNIIFCSVVLGTFICQIFIVEFGGKPFSCTSLSLSQWLWCLFIGIGELLWGQFISAIPTRSLKFLKEAGHGTTKEEITKDAEGLDEIDHAEMELRRGQILWFRGLNRIQTQIDVINTFQTGASFKGVLRRQNMGQHLDVKLVPSSSYIKVVKAFHSSLHESIQKPYNQKSIHSFMTHPEFAIEEELPRTPLLDEEEEENPDKASKFGTRVLLLDGEVTPYANTNNNAVDCNQVQLPQSDSSLQSLETSV
uniprot
proteins
ec_number
7.2.2.10
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}.
uniprot
proteins
mass_dalton
137920
uniprot
proteins
mutagenesis
MUTAGEN 672; /note="D->Q: Strongly decreased calcium transport activity. Slowed decomposition of the phosphorylated intermediate."; /evidence="ECO:0000269|PubMed:8530416"; MUTAGEN 674; /note="V->P: Decreased calcium transport activity."; /evidence="ECO:0000269|PubMed:8530416"; MUTAGEN 675; /note="R->K,D,L: Decreased calcium transport activity."; /evidence="ECO:0000269|PubMed:8530416"; MUTAGEN 686; /note="K->L: Decreased calcium transport activity."; /evidence="ECO:0000269|PubMed:8530416"; MUTAGEN 693; /note="R->I: Mildly decreased calcium transport activity."; /evidence="ECO:0000269|PubMed:8530416
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIB subfamily
uniprot
proteins
pubmed
10493800
uniprot
proteins
pubmed
12763866
uniprot
proteins
pubmed
1531651
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2137451
uniprot
proteins
pubmed
22084111
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2963820
uniprot
proteins
pubmed
2966397
uniprot
proteins
pubmed
7989379
uniprot
proteins
pubmed
8245032
uniprot
proteins
pubmed
8530416
uniprot
proteins
pubmed
8700162
uniprot
proteins
sequence_length
1241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2137451}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q6Q477}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 151..171; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 357..376; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 410..427; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 841..860; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 871..891; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 912..934; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 953..974; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 994..1015; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1026..1047; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins