P2RY8
entrez
286530
canonical
uniprot
Q86VZ1
canonical
ensembl
ENSG00000182162
resolver
ensembl
ENSG00000292333
resolver
ensp
ENSP00000370697
resolver
ensp
ENSP00000518610
resolver
ensp
ENSP00000552738
resolver
ensp
ENSP00000552739
resolver
ensp
ENSP00000552740
resolver
ensp
ENSP00000552741
resolver
ensp
ENSP00000630584
resolver
ensp
ENSP00000630585
resolver
ensp
ENSP00000642821
resolver
ensp
ENSP00000642822
resolver
ensp
ENSP00000642823
resolver
ensp
ENSP00000642824
resolver
ensp
ENSP00000642886
resolver
ensp
ENSP00000642887
resolver
ensp
ENSP00000815777
resolver
ensp
ENSP00000815779
resolver
ensp
ENSP00000815780
resolver
ensp
ENSP00000815837
resolver
ensp
ENSP00000815838
resolver
enst
ENST00000381297
resolver
enst
ENST00000711215
resolver
enst
ENST00000882679
resolver
enst
ENST00000882680
resolver
enst
ENST00000882681
resolver
enst
ENST00000882682
resolver
enst
ENST00000960525
resolver
enst
ENST00000960526
resolver
enst
ENST00000972959
resolver
enst
ENST00000972960
resolver
enst
ENST00000972961
resolver
enst
ENST00000972962
resolver
enst
ENST00000973024
resolver
enst
ENST00000973025
resolver
genesymbol
P2RY8
resolver
hgnc
HGNC:15524
resolver
uniprot_entry
P2RY8_HUMAN
resolver
amino_acid_sequence
MQVPNSTGPDNATLQMLRNPAIAVALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRLREYLGCRRVPRDTLDTRRESLFSARTTSVRSEAGAHPEGMEGATRPGLQRQESVF
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for S-geranylgeranyl-glutathione (GGG), an endogenous metabolite present in lymphoid tissues. Couples the binding of GGG to the activation of GNA13 and downstream repression of AKT activation in lymphocytes defining their positioning and growth within lymphoid organs (PubMed:25274307, PubMed:30842656, PubMed:34088745). In lymphoid follicles, confines B cells and follicular helper T cells in germinal centers (GCs) in response to GGG local gradients established by GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) with lower concentrations of GGG found in the follicular dendritic cell network region around which germinal centers are formed (PubMed:25274307, PubMed:30842656, PubMed:34088745). In the bone marrow, also in response to GGG gradients established by GGT5 and ABCC1, it restricts chemotactic transmigration of B cells, T cells and NK cells from blood vessels to the bone marrow parenchyma (PubMed:30842656, PubMed:34088745). Contributes to GNA13-dependent pathway that suppresses GC B cell growth (PubMed:25274307). {ECO:0000269|PubMed:25274307, ECO:0000269|PubMed:30842656, ECO:0000269|PubMed:34088745}.
uniprot
proteins
mass_dalton
40635
uniprot
proteins
mutagenesis
MUTAGEN 30; /note="Y->C: Loss of protein expression at the cell surface."; /evidence="ECO:0000269|PubMed:25274307"; MUTAGEN 163; /note="L->F: Loss of protein expression at the cell surface."; /evidence="ECO:0000269|PubMed:25274307"; MUTAGEN 164; /note="T->I: Loss of protein expression at the cell surface."; /evidence="ECO:0000269|PubMed:25274307"; MUTAGEN 205; /note="P->L: Loss of protein expression at the cell surface."; /evidence="ECO:0000269|PubMed:25274307"; MUTAGEN 206; /note="F->L: Loss of protein expression at the cell surface."; /evidence="ECO:0000269|PubMed:25274307"; MUTAGEN 290; /note="P->L: No effect on protein expression at the cell surface."; /evidence="ECO:0000269|PubMed:25274307
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11004484
uniprot
proteins
pubmed
15466006
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
25274307
uniprot
proteins
pubmed
30842656
uniprot
proteins
pubmed
34088745
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25274307}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 58..78; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 89..109; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 188..208; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 276..296; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins