Ppp5c
entrez
65179
canonical
uniprot
P53042
canonical
ensembl
ENSRNOG00000016907
resolver
ensembl
ENSRNOG00055031841
resolver
ensembl
ENSRNOG00060022634
resolver
ensembl
ENSRNOG00065032929
resolver
ensp
ENSRNOP00000023078
resolver
ensp
ENSRNOP00055045579
resolver
ensp
ENSRNOP00060032621
resolver
ensp
ENSRNOP00065046637
resolver
enst
ENSRNOT00055055135
resolver
enst
ENSRNOT00060039433
resolver
enst
ENSRNOT00065056658
resolver
genesymbol
Ppp5c
resolver
uniprot_entry
PPP5_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Autoinhibited. In the autoinhibited state, the TPR domain interacts with the catalytic region and prevents substrate access to the catalytic pocket. Allosterically activated by various polyunsaturated fatty acids, free long-chain fatty-acids and long-chain fatty acyl-CoA esters, arachidonic acid being the most effective activator. HSP90A and probably RAC1, GNA12 and GNA13 can also release the autoinhibition by the TPR repeat. Activation by RAC1, GNA12 and GNA13 is synergistic with the one produced by fatty acids binding. Inhibited by okadaic acid. {ECO:0000269|PubMed:11523989, ECO:0000269|PubMed:11969423, ECO:0000269|PubMed:16549782}.
uniprot
proteins
amino_acid_sequence
MAMAEGERTECAEPPRDEPPAEGTLKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPNDKDAKMKYQECSKIVKQKAFERAIAGDEHRRSVVDSLDIESMTIEDEYSGPKLEDGKVTITFMKDLMQWYKDQKKLHRKCAYQILVQVKEVLCKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSVSKRGVSCQFGPDVTKAFLEENQLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMAYANTLLQLGMM
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT (PubMed:11523989, PubMed:12176367, PubMed:15546861, PubMed:16549782, PubMed:16892053). Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses (By similarity). Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 (By similarity). Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress (By similarity). Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 (By similarity). Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E (By similarity). May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels (By similarity). Dephosphorylates and may play a role in the regulation of TAU/MAPT (PubMed:15546861). Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2 (PubMed:16549782). Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 (By similarity). {ECO:0000250|UniProtKB:P53041, ECO:0000250|UniProtKB:Q60676, ECO:0000269|PubMed:11523989, ECO:0000269|PubMed:12176367, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16549782, ECO:0000269|PubMed:16892053}.
uniprot
proteins
mass_dalton
56917
uniprot
proteins
mutagenesis
MUTAGEN 29; /note="E->A: No effect on phosphatase activity."; /evidence="ECO:0000269|PubMed:11523989"; MUTAGEN 32; /note="K->A: No effect on phosphatase activity."; /evidence="ECO:0000269|PubMed:11523989"; MUTAGEN 40; /note="K->A: Slightly reduces activation by arachidonic acid."; MUTAGEN 56; /note="E->A: No effect on phosphatase activity."; /evidence="ECO:0000269|PubMed:11523989"; MUTAGEN 63; /note="I->A: No effect on phosphatase activity."; /evidence="ECO:0000269|PubMed:11523989"; MUTAGEN 74; /note="R->A: No effect on phosphatase activity."; /evidence="ECO:0000269|PubMed:11523989"; MUTAGEN 76; /note="E->A: Increases basal phosphatase activity."; /evidence="ECO:0000269|PubMed:11523989"; MUTAGEN 77; /note="C->A: No effect on phosphatase activity."; /evidence="ECO:0000269|PubMed:11523989"; MUTAGEN 80; /note="Y->A: No effect on phosphatase activity."; /evidence="ECO:0000269|PubMed:11523989"; MUTAGEN 93; /note="K->E: Loss of inhibition of KCNH2 channel stimulation."; /evidence="ECO:0000269|PubMed:16549782"; MUTAGEN 97; /note="K->A: No effect on phosphatase activity."; /evidence="ECO:0000269|PubMed:11523989"; MUTAGEN 101; /note="R->A: No effect on phosphatase activity."; /evidence="ECO:0000269|PubMed:11523989"; MUTAGEN 126; /note="K->A: Loss of inhibition of KCNH2 channel stimulation."; /evidence="ECO:0000269|PubMed:16549782"; MUTAGEN 451; /note="Y->A: Insensitive to okadaic acid."; /evidence="ECO:0000269|PubMed:16549782
uniprot
proteins
post_translational_modification
PTM: Activated by at least two different proteolytic cleavages producing a 56 kDa and a 50 kDa form. {ECO:0000250}.
uniprot
proteins
protein_family
PP-5 (PP-T) subfamily
uniprot
proteins
protein_family
PPP phosphatase family
uniprot
proteins
pubmed
11523989
uniprot
proteins
pubmed
11969423
uniprot
proteins
pubmed
12176367
uniprot
proteins
pubmed
15546861
uniprot
proteins
pubmed
16549782
uniprot
proteins
pubmed
16790549
uniprot
proteins
pubmed
16892053
uniprot
proteins
pubmed
26182372
uniprot
proteins
pubmed
8077208
uniprot
proteins
sequence_length
499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12176367}. Cytoplasm {ECO:0000269|PubMed:12176367}. Cell membrane {ECO:0000250|UniProtKB:P53041}. Note=Predominantly nuclear. But also present in the cytoplasm. Translocates from the cytoplasm to the plasma membrane in a RAC1-dependent manner. {ECO:0000250|UniProtKB:P53041}.
uniprot
proteins