Slc5a11
entrez
252854
canonical
uniprot
Q9Z1F2
canonical
ensembl
ENSRNOG00000013407
resolver
ensp
ENSRNOP00000073553
resolver
enst
ENSRNOT00000090172
resolver
genesymbol
Slc5a11
resolver
genesymbol_syn
Cd74
resolver
genesymbol_syn
Kst1
resolver
genesymbol_syn
Smit2
resolver
uniprot
A0ACM8QDB8
resolver
uniprot
A6I8Z3
resolver
uniprot
B5DFE3
resolver
uniprot_entry
A0ACM8QDB8_RAT
resolver
uniprot_entry
A6I8Z3_RAT
resolver
uniprot_entry
SC5AB_RAT
resolver
uniprot_sec
B5DFE3
resolver
activity_regulation
ACTIVITY REGULATION: MI transport activity inhibited by D-chiro-inositol (DCI), phlorizin (Pz) and sodium (Na(+)) (PubMed:17932225). Insulin increases D-chiro-inositol uptake (By similarity). {ECO:0000250|UniProtKB:Q8WWX8, ECO:0000269|PubMed:17932225}.
uniprot
proteins
amino_acid_sequence
MESTTSSPQPPPSDALEAFPQKSMEPADIVVLVLYFLFVLAVGLWSTVRTKRDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSGAAVGISVAAYELNGLFSVLMLAWIFLPIYIAGQVTTMPEYLKRRFGGSRIPITLASIYPSTHSLTILQVDMYAGAIFIQQSLHLDLYLAIVGLLAVTALYTVAGGLAAVIYTDALQTVIMLIGAFILMGYSFAAVGGMEGLKDQYFLALASNRSENSSCGLPREDAFHIFRDPLTSDLPWPGILFGMSIPSLWYWCTDQVIVQRSLAAKNLSHAKGGSLMAAYLKVLPLFLMVFPGMVSRILFPDQVACAHPDICQRVCSNPSGCSDIAYPKLVLELLPTGLRGLMMAVMVAALMSSLTSIFNSASTIFTMDLWHHIRPRASERELMIVGRVFVLALVLVSILWIPVVQASQGGQLFIYIQSISSYLQPPVAVVFIMGCFWKRTNEKGAFSGLILGLLLGLVRLILDFVYVQPRCDQPDDRPAVVKDVHYLYFSMILSSTTLITVFTVSWFTETPSKEMVSRLTWFTRHEPVAQKDSVPPENPLSLTISQNGTTEATGISIQLESVQEATTKAHSDGVSPKQSKVLKAILWLCGMEKDKEEPPSKVEPVIVSLEENPLVKTLLDVNCIVCISCAIFLWGYFA
uniprot
proteins
function
FUNCTION: Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine (PubMed:17932225). Can also transport D-chiro-inositol (DCI) but not L-fucose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity). {ECO:0000250|UniProtKB:Q28728, ECO:0000250|UniProtKB:Q8WWX8, ECO:0000269|PubMed:17932225}.
uniprot
proteins
mass_dalton
73605
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17932225
uniprot
proteins
sequence_length
673
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:17932225}; Multi-pass membrane protein {ECO:0000269|PubMed:17932225}. Apical cell membrane {ECO:0000269|PubMed:17932225}; Multi-pass membrane protein {ECO:0000269|PubMed:17932225}. Note=Located on apical membrane of enterocytes. Located on membrane of kidney brush border membrane vesicles (BBMVs) and apical membrane of proximal convoluted tubules (By similarity). {ECO:0000250|UniProtKB:Q28728, ECO:0000269|PubMed:17932225}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..48; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 57..77; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 181..201; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 209..229; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 273..293; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 309..329; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 376..396; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 419..439; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 447..467; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 480..500; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 522..542; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 653..673; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins