Slc25a1
entrez
29743
canonical
uniprot
P32089
canonical
ensembl
ENSRNOG00000038001
resolver
ensembl
ENSRNOG00055003706
resolver
ensembl
ENSRNOG00060012833
resolver
ensembl
ENSRNOG00065007735
resolver
ensp
ENSRNOP00000000306
resolver
ensp
ENSRNOP00055004374
resolver
ensp
ENSRNOP00060017276
resolver
ensp
ENSRNOP00065008831
resolver
enst
ENSRNOT00000000306
resolver
enst
ENSRNOT00055005826
resolver
enst
ENSRNOT00060021831
resolver
enst
ENSRNOT00065012100
resolver
genesymbol
Slc25a1
resolver
genesymbol_syn
Slc20a3
resolver
uniprot
Q498T8
resolver
uniprot_entry
TXTP_RAT
resolver
uniprot_sec
Q498T8
resolver
amino_acid_sequence
MAAPRAPRALTAAAPGSGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERANPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSRRGLLCGLGAGVAEAVVVVCPMETVKVKFIHDQTSSNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYQGDNPNKPMNPLITGVFGAVAGAASVFGNTPLDVIKTRMQGLEAHKYRNTLDCGVQILKNEGPKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNKVWKTD
uniprot
proteins
function
FUNCTION: Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate (PubMed:2804096). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (By similarity). In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes (By similarity). {ECO:0000250|UniProtKB:P53007, ECO:0000269|PubMed:2804096}.
uniprot
proteins
mass_dalton
33835
uniprot
proteins
post_translational_modification
PTM: Possesses a short cleavable presequence, which, however, is found to be dispensable both for targeting to mitochondria and insertion into the inner membrane. However, the presequence is required to keep SLC25A1 in a soluble state and thus in an import-competent state. Mature SLC25A1 lacking the presequence is prone to aggregation. {ECO:0000269|PubMed:12488104}.
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
12488104
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2804096
uniprot
proteins
pubmed
8514800
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:12488104}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..46; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 86..105; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 129..143; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 183..202; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 224..241; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 278..297; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins