Fkbp6
entrez
288597
canonical
uniprot
D3ZQF4
canonical
ensembl
ENSRNOG00000001451
resolver
ensembl
ENSRNOG00055000299
resolver
ensembl
ENSRNOG00060011211
resolver
ensembl
ENSRNOG00065001161
resolver
ensp
ENSRNOP00000001971
resolver
ensp
ENSRNOP00000083089
resolver
ensp
ENSRNOP00055000376
resolver
ensp
ENSRNOP00060014780
resolver
ensp
ENSRNOP00065001062
resolver
enst
ENSRNOT00000001971
resolver
enst
ENSRNOT00000098264
resolver
enst
ENSRNOT00055000513
resolver
enst
ENSRNOT00060018950
resolver
enst
ENSRNOT00065001529
resolver
genesymbol
Fkbp6
resolver
genesymbol_syn
As
resolver
genesymbol_syn
Fkbp36
resolver
uniprot
A0A8I5ZW77
resolver
uniprot_entry
A0A8I5ZW77_RAT
resolver
uniprot_entry
FKBP6_RAT
resolver
amino_acid_sequence
MSVFSRLRNGIPPSRDDCQSPYERLSQRMLDISGDRGVLKDIIREGAGDPVTPDASVLVKYSGYLEHMDKPFDSNCFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPTYAYGTLGCPPLIPPNATVLFEIELIDFLDSAESDKFCALSAEQQEQFPLQKVLKVAATEREFGNYLFRQNRFCDAKVRYKRALLLLHRRLAICEEQHLVEPAELLVLLNLSFVYLKLDRPAMALRYGEQALLIDKRNAKALFRCGQACLLLTEYEQARDFLVRAQKEQPCNHDINNELKKLSSHYRDYVDREREMCHRMFAPCGSGSSVGGN
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Fkbp6 are the cause of spontaneous male sterile mutant 'As'. Males are sterile and aspermic due to abnormal pairing and misalignments between homologous chromosomes, non-homologous partner switches, and autosynapsis of X chromosome cores in meiotic spermatocytes (PubMed:12764197). {ECO:0000269|PubMed:12764197}.
uniprot
proteins
function
FUNCTION: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
37455
uniprot
proteins
protein_family
FKBP6 family
uniprot
proteins
pubmed
12764197
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (By similarity). {ECO:0000250}.
uniprot
proteins