Coq2
entrez
498332
canonical
uniprot
Q499N4
canonical
ensembl
ENSRNOG00000002194
resolver
ensp
ENSRNOP00000002987
resolver
genesymbol
Coq2
resolver
uniprot_entry
COQ2_RAT
resolver
amino_acid_sequence
MLRLGGAGLVRGLRVVSPAWLRGPGGLPLALARTTGTSGARDRRAPASGTQRGRALSLSAAAVVNSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIAAGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGSCDPAVCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFRENTKQWLSGFGVAMVGALSLVGASSGQTLPYYAAVAAVGAHLAHQIYTVDIHRAEDCWEKFTSNRTVGLLLFLGIVLGNLYKDKPDETKGVDAVGEESERTS
uniprot
proteins
ec_number
2.5.1.39
uniprot
proteins
function
FUNCTION: Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis (PubMed:20526342). Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group (such as all-trans-nonaprenyl diphosphate) (PubMed:20526342). The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9 (PubMed:20526342). However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10 (By similarity). Plays a central role in the biosynthesis of CoQ9 (By similarity). CoQ9 is a vital molecule that transports electrons from mitochondrial respiratory chain complexes (By similarity). CoQs also function as cofactors for uncoupling protein and plays a role as regulator of the extracellularly-induced ceramide-dependent apoptotic pathway (By similarity). Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner (PubMed:22387164). {ECO:0000250|UniProtKB:Q66JT7, ECO:0000250|UniProtKB:Q96H96, ECO:0000269|PubMed:20526342, ECO:0000269|PubMed:22387164}.
uniprot
proteins
mass_dalton
40406
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000305|PubMed:20526342}.
uniprot
proteins
protein_family
UbiA prenyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20526342
uniprot
proteins
pubmed
22387164
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03189}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03189}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03189}.
uniprot
proteins
transmembrane_region
TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03189"; TRANSMEM 109..129; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03189"; TRANSMEM 154..174; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03189"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03189"; TRANSMEM 201..221; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03189"; TRANSMEM 231..251; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03189"; TRANSMEM 278..298; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03189"; TRANSMEM 301..321; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03189"; TRANSMEM 333..353; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03189
uniprot
proteins