Abr
entrez
109934
canonical
uniprot
Q5SSL4
canonical
ensembl
ENSMUSG00000017631
resolver
ensp
ENSMUSP00000068982
resolver
ensp
ENSMUSP00000072522
resolver
ensp
ENSMUSP00000091551
resolver
ensp
ENSMUSP00000104044
resolver
ensp
ENSMUSP00000104045
resolver
ensp
ENSMUSP00000158745
resolver
enst
ENSMUST00000108407
resolver
enst
ENSMUST00000238684
resolver
genesymbol
Abr
resolver
uniprot
A0A571BG95
resolver
uniprot
E9PUE7
resolver
uniprot
Q3U5G0
resolver
uniprot
Q3UQJ6
resolver
uniprot
Q3UY38
resolver
uniprot
Q5SYJ5
resolver
uniprot
Q5SYJ7
resolver
uniprot
Q5SYJ8
resolver
uniprot
Q5SYJ9
resolver
uniprot
Q6PCY1
resolver
uniprot
Q6PDH3
resolver
uniprot_entry
A0A571BG95_MOUSE
resolver
uniprot_entry
ABR_MOUSE
resolver
uniprot_entry
E9PUE7_MOUSE
resolver
uniprot_sec
Q3U5G0
resolver
uniprot_sec
Q3UQJ6
resolver
uniprot_sec
Q3UY38
resolver
uniprot_sec
Q5SYJ5
resolver
uniprot_sec
Q5SYJ7
resolver
uniprot_sec
Q5SYJ8
resolver
uniprot_sec
Q5SYJ9
resolver
uniprot_sec
Q6PCY1
resolver
uniprot_sec
Q6PDH3
resolver
amino_acid_sequence
MEPLSHRGLPRLSWIDTLYSNFSYGAEDYDAEGHEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDSVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEMSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKTKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTTEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVESKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCIEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV
uniprot
proteins
function
FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (PubMed:20962234). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). {ECO:0000250|UniProtKB:Q12979, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:20962234}.
uniprot
proteins
mass_dalton
97667
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17116687
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20962234
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
859
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendritic spine {ECO:0000269|PubMed:20962234}. Cell projection, axon {ECO:0000269|PubMed:20962234}. Synapse {ECO:0000250|UniProtKB:A0A0G2JTR4}.
uniprot
proteins