Luzp1
entrez
269593
canonical
uniprot
Q8R4U7
canonical
ensembl
ENSMUSG00000001089
resolver
ensp
ENSMUSP00000001116
resolver
ensp
ENSMUSP00000060619
resolver
ensp
ENSMUSP00000101475
resolver
ensp
ENSMUSP00000130758
resolver
enst
ENSMUST00000001116
resolver
enst
ENSMUST00000063021
resolver
enst
ENSMUST00000105849
resolver
enst
ENSMUST00000170102
resolver
genesymbol
Luzp1
resolver
genesymbol_syn
Luzp
resolver
uniprot
A3KG96
resolver
uniprot
Q3UV18
resolver
uniprot
Q7TS71
resolver
uniprot
Q8BQW1
resolver
uniprot
Q99NG3
resolver
uniprot
Q9CSL6
resolver
uniprot_entry
LUZP1_MOUSE
resolver
uniprot_sec
A3KG96
resolver
uniprot_sec
Q3UV18
resolver
uniprot_sec
Q7TS71
resolver
uniprot_sec
Q8BQW1
resolver
uniprot_sec
Q99NG3
resolver
uniprot_sec
Q9CSL6
resolver
amino_acid_sequence
MAELTNYKDAASNRHLRFKLQSLSRRLDELEEATKNLQRAEDELLDLQDKVIQAEGSDSSTLAEIEVLRQRVLKIEGKDEEIKRAEDLCHTMKEKLEEEENLTRELKSEIERLQKRMVDLEKLEEALSRSKNECSQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLVSELEKLKSLTLSFVNERKYLNEKEKENEKIIKELTQKLEQNKKMNRDHMRNASTFLERNDLRIEDGISSTLSSKESKRKGSLDYLKQVENETRDKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMRAKNNDLQDNYLTELNRNRSLASQLEEIKLQVRKQKELGNGDIEGEDAFLLGRGRHERTKLKGHGSEASVSKHTSRELSPQHKRERLRNREFALSNEHYSLSSKQASSPVFTNKRAAKASNMGMGTDSGTQETKRTEDRFAPGSSHSEGKRGREQPSVLSRYPPAAQEHTKVWKGAPKPGTESGLKGKVEKTTRTFSDSTHVSVPNDIVGKGDKTSDLSSEAHCGKRGQVPGHASQGTQAVESSCSKAIGALSSSQKASSEGLSKGKKTANGLAADANFSNSKAPILSKYPYSSRSQENILQGFSLPNKEGVDQPVAVVMEDSSQHEALRCRVIKSSGREKPDSDDDLDIESFVTAKLVNTTITPEPEPKPQPNSREKVKSRGGTRTALFENDKNAAIENDSVKPTRPSSNAIEFPDANCAGVKNQRPFSPREALRSRAIIKPVIIDKDVKKIMGGSGTEVVLEKQKSTSKSVTSKVTSSITIYPSDSSGPRAVPSEAPRERHTSTSNIQVGPPELTAISNHVSSPLELSIHKHDITLQLTEAERVGDGSPKNRAEMVVSRSSILIKPSESVEKNSHVPPAETIRWKSHSASSDSRHITVRNAWKSKRDLKCSEDPPTGIGRNMEATNAYTQRPCTDFLELEQPRSQPSEQGARRVGNSGDAPELSPRRTQSSLTASEVLTRRDRMGGAITAASCNHSSSMEEGEDSTFVTSRRIHNPLEHSELPGKQGLPEPEPVWTEERLHPAKPYAEED
uniprot
proteins
function
FUNCTION: F-actin cross-linking protein (By similarity). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32553112). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (By similarity). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (By similarity). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (PubMed:33346378). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (PubMed:33869174). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (PubMed:34197713). Plays a role in embryonic brain and cardiovascular development (PubMed:18801334). {ECO:0000250|UniProtKB:Q86V48, ECO:0000269|PubMed:18801334, ECO:0000269|PubMed:32553112, ECO:0000269|PubMed:33346378, ECO:0000269|PubMed:33869174, ECO:0000269|PubMed:34197713}.
uniprot
proteins
mass_dalton
119311
uniprot
proteins
pubmed
11702014
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18801334
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32553112
uniprot
proteins
pubmed
33346378
uniprot
proteins
pubmed
33869174
uniprot
proteins
pubmed
34197713
uniprot
proteins
pubmed
8812416
uniprot
proteins
sequence_length
1068
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q86V48}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q86V48}. Midbody {ECO:0000250|UniProtKB:Q86V48}. Chromosome, centromere {ECO:0000250|UniProtKB:Q86V48}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q86V48}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q86V48}. Nucleus {ECO:0000250|UniProtKB:Q9ESV1}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9ESV1}. Perikaryon {ECO:0000250|UniProtKB:Q9ESV1}. Cell junction, tight junction {ECO:0000269|PubMed:33346378}. Note=Localizes to the proximal end of basal bodies (By similarity). During mitosis, localizes at the inner centromere in metaphase, at the central spindle in anaphase, and at the midbody in telophase (By similarity). Central spindle localization requires KIF20A while centromere localization requires the kinase activity of the chromosomal passenger complex (By similarity). {ECO:0000250|UniProtKB:Q86V48}.
uniprot
proteins