Myog
entrez
29148
canonical
uniprot
P20428
canonical
ensembl
ENSRNOG00000030743
resolver
ensp
ENSRNOP00000039817
resolver
genesymbol
Myog
resolver
uniprot
F7EW09
resolver
uniprot_entry
F7EW09_RAT
resolver
uniprot_entry
MYOG_RAT
resolver
amino_acid_sequence
MELYETSPYFYQEPHFYDGENYLPVHLQGFEPPGYERTELSLSPEARGPLEEKGLGTPEHCPGQCLPWACKVCKRKSVSVDRRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVEILRSAIQYIERLQALLSSLNQEERDLRYRGGGGPSRWYPVNATPTAPPAVRSGAMHWSLVPTQEIICSQLTLQVPTTCTPLRPSWTASRWRICLSPSQMKPCPTEIVCQAGCAWEPLSWCQTPPLLQQGPFKWGCPGAQKTALGCHKPDYPPSIHIRLTPSPAREFN
uniprot
proteins
function
FUNCTION: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Also cooperates with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Also plays a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts. {ECO:0000269|PubMed:14751541}.
uniprot
proteins
mass_dalton
32503
uniprot
proteins
mutagenesis
MUTAGEN 77; /note="S->A: Reduces phosphorylation."; /evidence="ECO:0000269|PubMed:14751541"; MUTAGEN 79; /note="S->A: Reduces phosphorylation."; /evidence="ECO:0000269|PubMed:14751541"; MUTAGEN 87; /note="T->A: Reduces phosphorylation and inhibits DNA-binding and transcriptional activation."; /evidence="ECO:0000269|PubMed:14751541
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles. {ECO:0000269|PubMed:14751541}.
uniprot
proteins
pubmed
14751541
uniprot
proteins
pubmed
1705035
uniprot
proteins
pubmed
2537150
uniprot
proteins
pubmed
9234731
uniprot
proteins
sequence_length
287
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos. {ECO:0000250}.
uniprot
proteins