CYP7A1
entrez
1581
canonical
uniprot
P22680
canonical
ensembl
ENSG00000167910
resolver
ensp
ENSP00000301645
resolver
enst
ENST00000301645
resolver
genesymbol
CYP7A1
resolver
genesymbol_syn
CYP7
resolver
hgnc
HGNC:2651
resolver
uniprot
P78454
resolver
uniprot
Q3MIL8
resolver
uniprot
Q7KZ19
resolver
uniprot_entry
CP7A1_HUMAN
resolver
uniprot_sec
P78454
resolver
uniprot_sec
Q3MIL8
resolver
uniprot_sec
Q7KZ19
resolver
amino_acid_sequence
MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKHL
uniprot
proteins
ec_number
1.14.14.23
uniprot
proteins
ec_number
1.14.14.26
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (PubMed:11013305, PubMed:12077124, PubMed:19965590, PubMed:21813643, PubMed:2384150). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:11013305, PubMed:12077124, PubMed:19965590, PubMed:21813643, PubMed:2384150). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis (PubMed:12077124, PubMed:19965590, PubMed:2384150). 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol (PubMed:11013305, PubMed:12077124). Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives (PubMed:21813643). {ECO:0000269|PubMed:11013305, ECO:0000269|PubMed:12077124, ECO:0000269|PubMed:19965590, ECO:0000269|PubMed:21813643, ECO:0000269|PubMed:2384150}.
uniprot
proteins
mass_dalton
57661
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; bile acid biosynthesis. {ECO:0000305|PubMed:11013305, ECO:0000305|PubMed:12077124, ECO:0000305|PubMed:2384150}.; PATHWAY: Steroid metabolism; cholesterol degradation. {ECO:0000305|PubMed:11013305, ECO:0000305|PubMed:12077124, ECO:0000305|PubMed:2384150}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
11013305
uniprot
proteins
pubmed
12077124
uniprot
proteins
pubmed
12721789
uniprot
proteins
pubmed
1312351
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15796896
uniprot
proteins
pubmed
1610352
uniprot
proteins
pubmed
19965590
uniprot
proteins
pubmed
21813643
uniprot
proteins
pubmed
2384150
uniprot
proteins
pubmed
8020987
uniprot
proteins
pubmed
8439551
uniprot
proteins
sequence_length
504
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:11013305, ECO:0000305|PubMed:2384150}; Single-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305|PubMed:11013305, ECO:0000305|PubMed:2384150}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins