Cpsf6
entrez
432508
canonical
uniprot
Q6NVF9
canonical
ensembl
ENSMUSG00000055531
resolver
ensp
ENSMUSP00000068408
resolver
ensp
ENSMUSP00000134823
resolver
ensp
ENSMUSP00000135136
resolver
ensp
ENSMUSP00000135150
resolver
ensp
ENSMUSP00000160494
resolver
ensp
ENSMUSP00000160495
resolver
ensp
ENSMUSP00000160496
resolver
ensp
ENSMUSP00000160500
resolver
ensp
ENSMUSP00000160502
resolver
enst
ENSMUST00000069168
resolver
enst
ENSMUST00000176670
resolver
enst
ENSMUST00000176686
resolver
enst
ENSMUST00000177145
resolver
genesymbol
Cpsf6
resolver
uniprot
H3BJ30
resolver
uniprot
H3BJW3
resolver
uniprot
Q8BX86
resolver
uniprot
Q8BXI8
resolver
uniprot_entry
CPSF6_MOUSE
resolver
uniprot_entry
H3BJ30_MOUSE
resolver
uniprot_entry
H3BJW3_MOUSE
resolver
uniprot_sec
Q8BX86
resolver
uniprot_sec
Q8BXI8
resolver
amino_acid_sequence
MADGVDHIDIYADVGEEFNQEAEYGGHDQIDLYDDVISPSANNGDAPEDRDYMDTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRANGQSKGFALVGVGSEASSKKLMDLLPKRELHGQSPVVTPCNKQFLSQFEMQSRKTTQSGQMSGEGKAGPPGGGSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYGPPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGIESKSYGSGSRRERSRERDHSRSREKSRRHKSRSRDRHDDYYRERSRERERHRDRDRDRDRERDREREYRHR
uniprot
proteins
function
FUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery. Plays a role in mRNA export. {ECO:0000250|UniProtKB:Q16630}.
uniprot
proteins
mass_dalton
59153
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylated in the Arg/Ser-rich domain by SRPK1, in vitro. {ECO:0000250|UniProtKB:Q16630}.; PTM: Symmetrically dimethylated on arginine residues by PRMT5 in a WDR77- and CLNS1A-dependent manner. Asymmetrically dimethylated on arginine residues by PRMT1. {ECO:0000250|UniProtKB:Q16630}.; PTM: Symmetrically dimethylated on arginine residues in the GAR motif by PRMT5 in a WDR77- and CLNS1A-dependent manner. Asymmetrically dimethylated on arginine residues in the GAR motif by PRMT1. {ECO:0000250|UniProtKB:Q16630}.
uniprot
proteins
protein_family
RRM CPSF6/7 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18032416
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29799838
uniprot
proteins
sequence_length
551
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q16630}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q16630}. Nucleus speckle {ECO:0000250|UniProtKB:Q16630}. Cytoplasm {ECO:0000250|UniProtKB:Q16630}. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm). Colocalizes with PSPC1 in punctate subnuclear structures often located adjacent to nuclear speckles, called paraspeckles, and corresponding to interchromatin granules-associated zones (IGAZs). Distribution in speckles and paraspeckles varies during the cell cycle. Associates at sites of active transcription on nascent perichromatin fibrils (PFs) and perichromatin granules. Nuclear import is mediated via interaction with TNPO3 independently of CPSF6 phosphorylation status. {ECO:0000250|UniProtKB:Q16630}.
uniprot
proteins