TNLG7A
entrez
10673
canonical
uniprot
Q9Y275
canonical
ensembl
ENSG00000102524
resolver
ensp
ENSP00000365048
resolver
ensp
ENSP00000389540
resolver
ensp
ENSP00000716263
resolver
genesymbol
TNFSF13B
resolver
genesymbol
TNLG7A
resolver
genesymbol_syn
BAFF
resolver
genesymbol_syn
BLYS
resolver
genesymbol_syn
TALL1
resolver
genesymbol_syn
TNFSF20
resolver
genesymbol_syn
ZTNF4
resolver
hgnc
HGNC:11929
resolver
uniprot
A0A0U5J7Q1
resolver
uniprot
E0ADT7
resolver
uniprot
Q6FHD6
resolver
uniprot
Q7Z5J2
resolver
uniprot_entry
A0A0U5J7Q1_HUMAN
resolver
uniprot_entry
TN13B_HUMAN
resolver
uniprot_sec
E0ADT7
resolver
uniprot_sec
Q6FHD6
resolver
uniprot_sec
Q7Z5J2
resolver
amino_acid_sequence
MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
uniprot
proteins
function
FUNCTION: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. {ECO:0000269|PubMed:10973284}.; FUNCTION: Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. {ECO:0000250}.; FUNCTION: [Isoform 3]: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. {ECO:0000269|PubMed:10973284}.
uniprot
proteins
mass_dalton
31223
uniprot
proteins
post_translational_modification
PTM: The soluble form derives from the membrane form by proteolytic processing.; PTM: Isoform 2 is not efficiently shed from the membrane unlike isoform 1. {ECO:0000250}.; PTM: N-glycosylated.
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
10331498
uniprot
proteins
pubmed
10359578
uniprot
proteins
pubmed
10398604
uniprot
proteins
pubmed
10973284
uniprot
proteins
pubmed
11827482
uniprot
proteins
pubmed
11853672
uniprot
proteins
pubmed
11862220
uniprot
proteins
pubmed
12867412
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22749832
uniprot
proteins
sequence_length
285
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 13b, soluble form]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 47..67; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins