DNAJC18
entrez
202052
canonical
uniprot
Q9H819
canonical
ensembl
ENSG00000170464
resolver
ensp
ENSP00000302843
resolver
enst
ENST00000302060
resolver
genesymbol
DNAJC18
resolver
hgnc
HGNC:28429
resolver
uniprot_entry
DJC18_HUMAN
resolver
amino_acid_sequence
MAATLGSGERWTEAYIDAVRRNKYPEDTPPESHDPCGCCNCMKAQKEKKSENEWTQTRQGEGNSTYSEEQLLGVQRIKKCRNYYEILGVSRDASDEELKKAYRKLALKFHPDKNCAPGATDAFKAIGNAFAVLSNPDKRLRYDEYGDEQVTFTAPRARPYNYYRDFEADITPEELFNVFFGGHFPTGNIHMFSNVTDDTYYYRRRHRHERTQTQKEEEEEKPQTTYSAFIQLLPVLVIVIISVITQLLATNPPYSLFYKSTLGYTISRETQNLQVPYFVDKNFDKAYRGASLHDLEKTIEKDYIDYIQTSCWKEKQQKSELTNLAGLYRDERLKQKAESLKLENCEKLSKLIGLRRGG
uniprot
proteins
function
FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:25631089). Regulates the recruitment of DNAJB12:DNAJB14 into SV40-induced foci and all cooperate to guide SV40 across the endoplasmic reticulum membrane. The foci represent the site from which SV40 penetrates into the cytosol (PubMed:25631089). {ECO:0000269|PubMed:25631089}.
uniprot
proteins
mass_dalton
41551
uniprot
proteins
mutagenesis
MUTAGEN 110; /note="H->Q: Loss of colocalization with SV40-induced foci upon SV40 invection."; /evidence="ECO:0000269|PubMed:25631089
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25631089
uniprot
proteins
sequence_length
358
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25631089}; Single-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: Note=(Microbial infection) Upon SV40 infection, colocalizes with BCAP31, DNAJB12 and DNAJB14 in punctate structures within the endoplasmic reticulum membrane. {ECO:0000269|PubMed:25631089}.
uniprot
proteins
transmembrane_region
TRANSMEM 228..248; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins