ADHFE1
entrez
137872
canonical
uniprot
Q8IWW8
canonical
ensembl
ENSG00000147576
resolver
ensembl
ENSG00000285791
resolver
ensp
ENSP00000379865
resolver
genesymbol
ADHFE1
resolver
hgnc
HGNC:16354
resolver
uniprot
B4DTJ8
resolver
uniprot
Q49A19
resolver
uniprot
Q68CI7
resolver
uniprot
Q6P2B6
resolver
uniprot
Q96MF9
resolver
uniprot_entry
HOT_HUMAN
resolver
uniprot_sec
B4DTJ8
resolver
uniprot_sec
Q49A19
resolver
uniprot_sec
Q68CI7
resolver
uniprot_sec
Q6P2B6
resolver
uniprot_sec
Q96MF9
resolver
amino_acid_sequence
MAAAARARVAYLLRQLQRAACQCPTHSHTYSQAPGLSPSGKTTDYAFEMAVSNIRYGAAVTKEVGMDLKNMGAKNVCLMTDKNLSKLPPVQVAMDSLVKNGIPFTVYDNVRVEPTDSSFMEAIEFAQKGAFDAYVAVGGGSTMDTCKAANLYASSPHSDFLDYVSAPIGKGKPVSVPLKPLIAVPTTSGTGSETTGVAIFDYEHLKVKIGITSRAIKPTLGLIDPLHTLHMPARVVANSGFDVLCHALESYTTLPYHLRSPCPSNPITRPAYQGSNPISDIWAIHALRIVAKYLKRAVRNPDDLEARSHMHLASAFAGIGFGNAGVHLCHGMSYPISGLVKMYKAKDYNVDHPLVPHGLSVVLTSPAVFTFTAQMFPERHLEMAEILGADTRTARIQDAGLVLADTLRKFLFDLDVDDGLAAVGYSKADIPALVKGTLPQERVTKLAPCPQSEEDLAALFEASMKLY
uniprot
proteins
ec_number
1.1.99.24
uniprot
proteins
function
FUNCTION: Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities. {ECO:0000269|PubMed:16435184}.
uniprot
proteins
mass_dalton
50308
uniprot
proteins
protein_family
Hydroxyacid-oxoacid transhydrogenase subfamily
uniprot
proteins
protein_family
Iron-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
12592711
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15221005
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16435184
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
uniprot
proteins