Nf2
entrez
18016
canonical
uniprot
P46662
canonical
ensembl
ENSMUSG00000009073
resolver
ensp
ENSMUSP00000055033
resolver
ensp
ENSMUSP00000055061
resolver
ensp
ENSMUSP00000105536
resolver
ensp
ENSMUSP00000171027
resolver
ensp
ENSMUSP00000171029
resolver
ensp
ENSMUSP00000171031
resolver
ensp
ENSMUSP00000171040
resolver
ensp
ENSMUSP00000171047
resolver
ensp
ENSMUSP00000339873
resolver
genesymbol
Nf2
resolver
genesymbol_syn
Nf-2
resolver
uniprot
Q3TIW4
resolver
uniprot
Q8BR03
resolver
uniprot
Q9D3K3
resolver
uniprot_entry
MERL_MOUSE
resolver
uniprot_entry
Q3TIW4_MOUSE
resolver
uniprot_entry
Q9D3K3_MOUSE
resolver
uniprot_sec
Q8BR03
resolver
amino_acid_sequence
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKVYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFTIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPPPLPPDIPSFDIIADSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDVLHSESSDRGGPSSKHNTIKKLTLQSAKSRVAFFEEL
uniprot
proteins
function
FUNCTION: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex (By similarity). Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintenance of cell polarity and separation of the lens vesicle from the corneal epithelium. {ECO:0000250|UniProtKB:P35240, ECO:0000269|PubMed:20181838}.
uniprot
proteins
mass_dalton
69776
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-518 inhibits nuclear localization by disrupting the intramolecular association of the FERM domain with the C-terminal tail. The dephosphorylation of Ser-518 favors the interaction with NOP53. {ECO:0000250|UniProtKB:P35240}.; PTM: Ubiquitinated by the CUL4A-RBX1-DDB1-DCAF1/VprBP E3 ubiquitin-protein ligase complex for ubiquitination and subsequent proteasome-dependent degradation. {ECO:0000250}.
uniprot
proteins
pubmed
15913605
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20181838
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7981675
uniprot
proteins
pubmed
8012352
uniprot
proteins
pubmed
8088840
uniprot
proteins
sequence_length
596
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with MPP1 in non-myelin-forming Schwann cells. Binds with DCAF1 in the nucleus. The intramolecular association of the FERM domain with the C-terminal tail promotes nuclear accumulation. The unphosphorylated form accumulates predominantly in the nucleus while the phosphorylated form is largely confined to the non-nuclear fractions (By similarity). {ECO:0000250}.
uniprot
proteins