Akr7a2
entrez
110198
canonical
uniprot
Q8CG76
canonical
ensembl
ENSMUSG00000028743
resolver
ensp
ENSMUSP00000073459
resolver
enst
ENSMUST00000073787
resolver
genesymbol
Akr7a2
resolver
genesymbol_syn
Afar
resolver
genesymbol_syn
Akr7a5
resolver
uniprot
A2AMV3
resolver
uniprot
Q3UPU2
resolver
uniprot
Q8CG77
resolver
uniprot
Q8JZQ8
resolver
uniprot
Q9D157
resolver
uniprot_entry
ARK72_MOUSE
resolver
uniprot_sec
A2AMV3
resolver
uniprot_sec
Q3UPU2
resolver
uniprot_sec
Q8CG77
resolver
uniprot_sec
Q8JZQ8
resolver
uniprot_sec
Q9D157
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by citrate, succinate and tartrate. {ECO:0000269|PubMed:16460003}.
uniprot
proteins
amino_acid_sequence
MLRAASRAVGRAAVRSAQRSGTSVGRPLAMSRPPPPRAASGAPLRPATVLGTMEMGRRMDASASAASVRAFLERGHSELDTAFMYCDGQSENILGGLGLGLGSGDCTVKIATKANPWEGKSLKPDSIRSQLETSLKRLQCPRVDLFYLHAPDHSTPVEETLRACHQLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVEAELLPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNNWAETYRNRFWKEHHFEAIALVEKALQTTYGTNAPRMTSAALRWMYHHSQLQGTRGDAVILGMSSLEQLEQNLAATEEGPLEPAVVEAFDQAWNMVAHECPNYFR
uniprot
proteins
ec_number
1.1.1.n11
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity). {ECO:0000250, ECO:0000269|PubMed:16460003}.
uniprot
proteins
mass_dalton
40612
uniprot
proteins
protein_family
Aldo/keto reductase 2 subfamily
uniprot
proteins
protein_family
Aldo/keto reductase family
uniprot
proteins
pubmed
12071861
uniprot
proteins
pubmed
12123834
uniprot
proteins
pubmed
12879023
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16460003
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255}. Golgi apparatus {ECO:0000250|UniProtKB:Q8CG45}. Cytoplasm {ECO:0000250|UniProtKB:O43488}.
uniprot
proteins