Skic2
entrez
108077
canonical
uniprot
Q6NZR5
canonical
ensembl
ENSMUSG00000040356
resolver
ensp
ENSMUSP00000036265
resolver
enst
ENSMUST00000046022
resolver
genesymbol
Skic2
resolver
genesymbol_syn
Skiv2l
resolver
uniprot
Q3TW36
resolver
uniprot
Q8C2W7
resolver
uniprot_entry
Q8C2W7_MOUSE
resolver
uniprot_entry
SKI2_MOUSE
resolver
uniprot_sec
Q3TW36
resolver
amino_acid_sequence
MMETERLVLPPLDPLNLPLRALEVGCTGRWELLNVPGPPESTLPHGLPPCAPDLCQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAAVETPVPSDLQAQRHPTTGHILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDEPSITDLHTREEAEEEIDFEKDLLTVPPGFKKGVDFAPKDHPAPVPGLLSLSRLLEPLDLSGGDEDEGEAAGGPRGDNASPSPSGTPLVRASSLEDLVLKEAATVVSTPEPPKPPPQEQWAVPVDVTSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLEQHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPEHVSIILLSATVPNALEFADWIGRLKRRQIYVISTVARPVPLEHYLFTGNSPKTQGELFLLLDSRGAFHTQGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSELLRRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALADLTKRLGALEEPDVTGQLADLPEYYSWAEELTETQNMIQRRIMESVNGLKSLSVGRVVVVKNEEHHNALGVILQVSSNSTSRVFTTLVLCDKPVVSDNPRDKGPATPDVPHPDDLIGFKLFLPEGPCEHTVAKLQPGDVAAISTKVLRVNGEKISEDFSKRQQPKFRKDPPLAAVTTAVQELLRLAQSYPAGPPTLDPINDLQLKDVAVVEGGLRARKLEELIRGAQCVHSPRFPAQYVKLRERMQIQKEMERLRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSSHELLLTELMFDNALSALRPEEIAALLSGLVCQSPGDPGDQLPSTLKQGVERVKAVAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATLLRRDIVFAASLYTQ
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon. {ECO:0000250|UniProtKB:Q15477}.
uniprot
proteins
mass_dalton
137524
uniprot
proteins
protein_family
Helicase family
uniprot
proteins
protein_family
SKI2 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
1244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15477}. Cytoplasm {ECO:0000250|UniProtKB:Q15477}.
uniprot
proteins