FAM83D
entrez
81610
canonical
uniprot
Q9H4H8
canonical
ensembl
ENSG00000101447
resolver
ensp
ENSP00000481465
resolver
genesymbol
FAM83D
resolver
genesymbol_syn
C20orf129
resolver
hgnc
HGNC:16122
resolver
uniprot
B4E1I7
resolver
uniprot
Q5THR2
resolver
uniprot
Q68EN1
resolver
uniprot
Q6P457
resolver
uniprot
Q7Z6H0
resolver
uniprot
Q96DF5
resolver
uniprot
Q96N89
resolver
uniprot
Q9BVM8
resolver
uniprot_entry
FA83D_HUMAN
resolver
uniprot_sec
B4E1I7
resolver
uniprot_sec
Q5THR2
resolver
uniprot_sec
Q68EN1
resolver
uniprot_sec
Q6P457
resolver
uniprot_sec
Q7Z6H0
resolver
uniprot_sec
Q96DF5
resolver
uniprot_sec
Q96N89
resolver
uniprot_sec
Q9BVM8
resolver
amino_acid_sequence
MALLSEGLDEVPAACLSPCGPPNPTELFSESRRLALEELVAGGPEAFAAFLRRERLARFLNPDEVHAILRAAERPGEEGAAAAAAAEDSFGSSHDCSSGTYFPEQSDLEPPLLELGWPAFYQGAYRGATRVETHFQPRGAGEGGPYGCKDALRQQLRSAREVIAVVMDVFTDIDIFRDLQEICRKQGVAVYILLDQALLSQFLDMCMDLKVHPEQEKLMTVRTITGNIYYARSGTKIIGKVHEKFTLIDGIRVATGSYSFTWTDGKLNSSNLVILSGQVVEHFDLEFRILYAQSKPISPKLLSHFQSSNKFDHLTNRKPQSKELTLGNLLRMRLARLSSTPRKADLDPEMPAEGKAERKPHDCESSTVSEEDYFSSHRDELQSRKAIDAATQTEPGEEMPGLSVSEVGTQTSITTACAGTQTAVITRIASSQTTIWSRSTTTQTDMDENILFPRGTQSTEGSPVSKMSVSRSSSLKSSSSVSSQGSVASSTGSPASIRTTDFHNPGYPKYLGTPHLELYLSDSLRNLNKERQFHFAGIRSRLNHMLAMLSRRTLFTENHLGLHSGNFSRVNLLAVRDVALYPSYQ
uniprot
proteins
disease_involvement
DISEASE: Note=Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition (PubMed:24344117, PubMed:24736947, PubMed:25646692). Expression increased in hepatocellular carcinoma, promotes proliferation and cell colony formation via activation of MEK/ERK signaling (PubMed:25646692). Expression increased in breast cancer; may be a prognostic indicator of poor disease-free survival (PubMed:24344117). {ECO:0000269|PubMed:24344117, ECO:0000269|PubMed:24736947, ECO:0000269|PubMed:25646692}.
uniprot
proteins
function
FUNCTION: Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (PubMed:18485706). {ECO:0000269|PubMed:18485706, ECO:0000269|PubMed:24344117, ECO:0000269|PubMed:25646692}.
uniprot
proteins
mass_dalton
64424
uniprot
proteins
mutagenesis
MUTAGEN 391..393; /note="TQT->AAA: Abolishes interaction with DYNLL1 and no effect on interaction with HMMR; when associated with 409-A--A-411 and 442-A--A-444."; /evidence="ECO:0000269|PubMed:22965910"; MUTAGEN 409..411; /note="TQT->AAA: Abolishes interaction with DYNLL1 and no effect on interaction with HMMR; when associated with 391-A--A-393 and 442-A--A-444."; /evidence="ECO:0000269|PubMed:22965910"; MUTAGEN 442..444; /note="TQT->AAA: Abolishes interaction with DYNLL1 and no effect on interaction with HMMR; when associated with 391-A--A-393 and 409-A--A-411."; /evidence="ECO:0000269|PubMed:22965910
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during mitosis. {ECO:0000269|PubMed:18485706}.
uniprot
proteins
protein_family
SACK1 family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15561729
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18445686
uniprot
proteins
pubmed
18485706
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22965910
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24344117
uniprot
proteins
pubmed
24736947
uniprot
proteins
pubmed
25646692
uniprot
proteins
pubmed
29789297
uniprot
proteins
pubmed
31338967
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:29789297}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:15561729, ECO:0000269|PubMed:18485706}. Note=Primarily cytoplasmic during interphase, but at prophase, associates with spindle microtubules, with a clear concentration toward the spindle poles. It persists on spindle microtubules through metaphase and anaphase. {ECO:0000269|PubMed:18485706}.
uniprot
proteins