Camk1
entrez
171503
canonical
uniprot
Q63450
canonical
ensembl
ENSRNOG00000021781
resolver
ensembl
ENSRNOG00055007856
resolver
ensembl
ENSRNOG00060013595
resolver
ensembl
ENSRNOG00065027661
resolver
ensp
ENSRNOP00000033456
resolver
ensp
ENSRNOP00000091265
resolver
ensp
ENSRNOP00055010570
resolver
ensp
ENSRNOP00060018403
resolver
ensp
ENSRNOP00065039116
resolver
enst
ENSRNOT00000029728
resolver
enst
ENSRNOT00000093950
resolver
enst
ENSRNOT00055013194
resolver
enst
ENSRNOT00060023204
resolver
enst
ENSRNOT00065047693
resolver
genesymbol
Camk1
resolver
uniprot
A0A8I6AEY2
resolver
uniprot
A0A8L2UL04
resolver
uniprot
Q63084
resolver
uniprot_entry
A0A8I6AEY2_RAT
resolver
uniprot_entry
A0A8L2UL04_RAT
resolver
uniprot_entry
KCC1A_RAT
resolver
uniprot_sec
Q63084
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-177 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-177 results in several fold increase in total activity. Unlike CaMK4, is unable to exhibit autonomous activity after Ca(2+)/calmodulin activation. {ECO:0000269|PubMed:8631893, ECO:0000269|PubMed:8702851}.
uniprot
proteins
amino_acid_sequence
MPGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKKALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPTAGGPAAGCCCRDCCVEPGSELPPAPPPSSRAMD
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-516', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation (By similarity). Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-275' and 'Ser-294'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. {ECO:0000250, ECO:0000269|PubMed:12081505, ECO:0000269|PubMed:15084659, ECO:0000269|PubMed:15689566, ECO:0000269|PubMed:1646483, ECO:0000269|PubMed:16772171, ECO:0000269|PubMed:17022975, ECO:0000269|PubMed:21107644, ECO:0000269|PubMed:8621702}.
uniprot
proteins
mass_dalton
41638
uniprot
proteins
mutagenesis
MUTAGEN 177; /note="T->A: Loss of activation by CaMKK1 and CaMKK2."; /evidence="ECO:0000269|PubMed:8631893"; MUTAGEN 263..264; /note="KR->AA: Partially excluded from the nucleus; when associated with 319-AQA-321."; /evidence="ECO:0000269|PubMed:15147908"; MUTAGEN 319..321; /note="LQL->AQA: Retention in the nucleus. Partially excluded from the nucleus; when associated with 263-AA-264."; /evidence="ECO:0000269|PubMed:15147908
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CaMKK1 and CaMKK2 on Thr-177. {ECO:0000269|PubMed:8631893}.; PTM: Polybiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL12), leading to proteasomal degradation. {ECO:0000250}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10936699
uniprot
proteins
pubmed
12081505
uniprot
proteins
pubmed
12475216
uniprot
proteins
pubmed
15084659
uniprot
proteins
pubmed
15147908
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15689566
uniprot
proteins
pubmed
1646483
uniprot
proteins
pubmed
16772171
uniprot
proteins
pubmed
17022975
uniprot
proteins
pubmed
21107644
uniprot
proteins
pubmed
7624832
uniprot
proteins
pubmed
7698321
uniprot
proteins
pubmed
7948038
uniprot
proteins
pubmed
8253780
uniprot
proteins
pubmed
8386178
uniprot
proteins
pubmed
8601311
uniprot
proteins
pubmed
8621702
uniprot
proteins
pubmed
8631893
uniprot
proteins
pubmed
8702851
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
uniprot
proteins