FXYD6
entrez
53826
canonical
uniprot
Q9H0Q3
canonical
ensembl
ENSG00000137726
resolver
ensembl
ENSG00000255245
resolver
ensp
ENSP00000260282
resolver
ensp
ENSP00000431446
resolver
ensp
ENSP00000433312
resolver
ensp
ENSP00000442756
resolver
ensp
ENSP00000463158
resolver
genesymbol
FXYD6
resolver
hgnc
HGNC:4030
resolver
uniprot
A8K0R4
resolver
uniprot
J3QLD2
resolver
uniprot
Q6FIG9
resolver
uniprot
Q6UW52
resolver
uniprot_entry
FXYD6_HUMAN
resolver
uniprot_sec
A8K0R4
resolver
uniprot_sec
J3QLD2
resolver
uniprot_sec
Q6FIG9
resolver
uniprot_sec
Q6UW52
resolver
amino_acid_sequence
MELVLVFLCSLLAPMVLASAAEKEKEMDPFHYDYQTLRIGGLVFAVVLFSVGILLILSRRCKCSFNQKPRAPGDEEAQVENLITANATEPQKAEN
uniprot
proteins
function
FUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Reduces the apparent affinity for intracellular Na(+) with no change in the apparent affinity for extracellular K(+) (PubMed:33231612). In addition to modulating NKA kinetics, may also function as a regulator of NKA localization to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:Q91XV6, ECO:0000269|PubMed:33231612}.
uniprot
proteins
mass_dalton
10542
uniprot
proteins
protein_family
FXYD family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15146197
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
33231612
uniprot
proteins
pubmed
36075933
uniprot
proteins
sequence_length
95
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q91XV6}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..57; /note="Helical"; /evidence="ECO:0000269|PubMed:36075933, ECO:0007744|PDB:8D3V
uniprot
proteins