FASTK
entrez
10922
canonical
uniprot
Q14296
canonical
ensembl
ENSG00000164896
resolver
ensp
ENSP00000297532
resolver
ensp
ENSP00000324817
resolver
ensp
ENSP00000418516
resolver
ensp
ENSP00000569801
resolver
ensp
ENSP00000676716
resolver
ensp
ENSP00000676719
resolver
ensp
ENSP00000704766
resolver
ensp
ENSP00000704768
resolver
ensp
ENSP00000736733
resolver
genesymbol
FASTK
resolver
hgnc
HGNC:24676
resolver
uniprot
A8K867
resolver
uniprot
F8VTW9
resolver
uniprot
Q59EM8
resolver
uniprot
Q8IVA0
resolver
uniprot_entry
FASTK_HUMAN
resolver
uniprot_sec
A8K867
resolver
uniprot_sec
F8VTW9
resolver
uniprot_sec
Q59EM8
resolver
uniprot_sec
Q8IVA0
resolver
amino_acid_sequence
MRRPRGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQPCCLGPSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQLLGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCALEQERRLRLPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
2.7.11.8
uniprot
proteins
function
FUNCTION: Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. {ECO:0000269|PubMed:17135269, ECO:0000269|PubMed:7544399}.; FUNCTION: [Isoform 4]: Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels. {ECO:0000269|PubMed:25704814}.
uniprot
proteins
mass_dalton
61104
uniprot
proteins
mutagenesis
MUTAGEN 35; /note="M->G: Abolishes isoform 4 expression."; /evidence="ECO:0000269|PubMed:25704814
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on serine/threonine residues. Activated by dephosphorylation. {ECO:0000269|PubMed:7544399}.
uniprot
proteins
protein_family
FAST protein kinase family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17135269
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
25704814
uniprot
proteins
pubmed
7544399
uniprot
proteins
sequence_length
549
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 4]: Mitochondrion matrix {ECO:0000269|PubMed:25704814}. Note=Colocalizes with mitochondrial RNA granules. {ECO:0000269|PubMed:25704814}.
uniprot
proteins