NMBR
entrez
4829
canonical
uniprot
P28336
canonical
ensembl
ENSG00000135577
resolver
ensp
ENSP00000258042
resolver
enst
ENST00000258042
resolver
genesymbol
NMBR
resolver
hgnc
HGNC:7843
resolver
uniprot
E9KL38
resolver
uniprot
Q5VUK8
resolver
uniprot_entry
NMBR_HUMAN
resolver
uniprot_sec
E9KL38
resolver
uniprot_sec
Q5VUK8
resolver
amino_acid_sequence
MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAVRMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
uniprot
proteins
function
FUNCTION: Receptor for neuromedin-B (PubMed:1655761). Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity). {ECO:0000250|UniProtKB:O54799, ECO:0000269|PubMed:1655761, ECO:0000269|PubMed:31601264}.
uniprot
proteins
mass_dalton
43435
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
1655761
uniprot
proteins
pubmed
20736409
uniprot
proteins
pubmed
31601264
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..65; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 80..99; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 118..139; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 157..177; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 212..235; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 267..287; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 300..327; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins