Alg6
entrez
320438
canonical
uniprot
Q3TAE8
canonical
ensembl
ENSMUSG00000073792
resolver
ensp
ENSMUSP00000095574
resolver
ensp
ENSMUSP00000267443
resolver
ensp
ENSMUSP00000267446
resolver
ensp
ENSMUSP00000267450
resolver
ensp
ENSMUSP00000267452
resolver
ensp
ENSMUSP00000267463
resolver
ensp
ENSMUSP00000267471
resolver
enst
ENSMUST00000097961
resolver
genesymbol
Alg6
resolver
uniprot
Q3TZF4
resolver
uniprot_entry
ALG6_MOUSE
resolver
uniprot_sec
Q3TZF4
resolver
amino_acid_sequence
MESWPWMAVVVLLGLTVRWTVSLSSYSGAGKPPMFGDYEAQRHWQEITLNLPVKQWYFNSSDNNLLYWGLDYPPLTAYHSLLCAYVAKFINPDWVALHTSRGYESQAHKLFMRATVLAADLLIYVPAVLLYCYSLKEISPKRKIASALCILLYPGLILIDYGHFQYNSVSLGFALWGVLGVSWDWDLLGSLAFCLALNYKQMELYHSLPFFCFLLGKCFKKGLKGKGLALFIRIACTVLASFLLCWLPFLTEREHALQVVRRLFPVDRGLFEDKVANIWCSVNVFLKIKDTLPRHIQIAISFCFTLLSLLPACIKLTVRPSCKGFRFTLVSCALSFFLFSFQVHEKSILLVSLPVCLVLTEIPFMSTWFLLVSTFSMLPLLLKDELLLPSVVTVMAFVIACGTFFPMLENTSEEQLQLKSFAVSVRRHLPGFTFLPRIMQCLFLSSVITMVLLTILSVTLDPPQKLPDLFPVLICFVSCVNFVFFLVYFNIVIMWDSKNGRNRKKIE
uniprot
proteins
ec_number
2.4.1.267
uniprot
proteins
function
FUNCTION: Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Man(9)GlcNAc(2)-PP-Dol to produce Glc(1)Man(9)GlcNAc(2)-PP-Dol. Glc(1)Man(9)GlcNAc(2)-PP-Dol is a substrate for ALG8, the following enzyme in the biosynthetic pathway. {ECO:0000250|UniProtKB:Q9Y672}.
uniprot
proteins
mass_dalton
57874
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q9Y672}.
uniprot
proteins
protein_family
ALG6/ALG8 glucosyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
507
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y672}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 3..23; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 230..250; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 298..318; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 333..353; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 386..406; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 438..458; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 469..489; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins