Mup20
entrez
381530
canonical
uniprot
Q5FW60
canonical
ensembl
ENSMUSG00000078672
resolver
ensp
ENSMUSP00000073667
resolver
ensp
ENSMUSP00000289128
resolver
enst
ENSMUST00000074018
resolver
genesymbol
Mup20
resolver
genesymbol_syn
Mup24
resolver
uniprot_entry
MUP20_MOUSE
resolver
amino_acid_sequence
MKLLVLLLCLGLTLVCVHAEEASSMERNFNVEKINGEWYTIMLATDKREKIEEHGSMRVFVEYIHVLENSLALKFHIIINEECSEIFLVADKTEKAGEYSVTYDGSNTFTILKTDYDNYIMIHLINKKDGETFQLMELYGREPDLSSDIKEKFAQLSEEHGIVRENIIDLTNANRCLEARE
uniprot
proteins
function
FUNCTION: Male pheromone which stimulates female sexual attraction to male urinary scent and promotes a strong learned attraction to the airborne urinary odor of an individual male (PubMed:20525243, PubMed:31996852). Promotes spatial learning by rapidly conditioning preference for its remembered location among females and competitor males so that animals prefer to spend time in the site even when scent is absent (PubMed:23239735). In addition to promoting a rapid attraction response, also elicits ultrasonic vocalizations and urinary scent marking in females which do not occur immediately after exposure (PubMed:31996852). Stimulates hippocampal neurogenesis and cell proliferation in the subventricular zone in females (PubMed:25972792). Promotes male aggressive behavior (PubMed:18064011). Response to Mup20 is mediated by a neural circuit extending from the accessory olfactory bulb to a subset of nitric oxidase synthase-expressing neurons in the medial amygdala (PubMed:31996852). As well as acting as a pheromone itself, binds most of the male pheromone, 2-sec-butyl-4,5-dihydrothiazole, in urine and is responsible for its slow release from scent marks (PubMed:15934926, PubMed:25279835). {ECO:0000269|PubMed:15934926, ECO:0000269|PubMed:18064011, ECO:0000269|PubMed:20525243, ECO:0000269|PubMed:23239735, ECO:0000269|PubMed:25279835, ECO:0000269|PubMed:25972792, ECO:0000269|PubMed:31996852}.
uniprot
proteins
mass_dalton
20930
uniprot
proteins
protein_family
Calycin superfamily
uniprot
proteins
protein_family
Lipocalin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15934926
uniprot
proteins
pubmed
18064011
uniprot
proteins
pubmed
18815613
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20525243
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23239735
uniprot
proteins
pubmed
25279835
uniprot
proteins
pubmed
25972792
uniprot
proteins
pubmed
28522864
uniprot
proteins
pubmed
29511252
uniprot
proteins
pubmed
31996852
uniprot
proteins
sequence_length
181
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15934926, ECO:0000269|PubMed:20525243, ECO:0000269|PubMed:25279835, ECO:0000269|PubMed:28522864}.
uniprot
proteins