Ifitm5
entrez
73835
canonical
uniprot
O88728
canonical
ensembl
ENSMUSG00000025489
resolver
ensp
ENSMUSP00000026562
resolver
enst
ENSMUST00000026562
resolver
genesymbol
Ifitm5
resolver
genesymbol_syn
Bril
resolver
genesymbol_syn
Fragilis4
resolver
uniprot_entry
IFM5_MOUSE
resolver
amino_acid_sequence
MDTSYPREDPRAPSSRKADAAAHTALSMGTPGPTPRDHMLWSVFSTMYLNLCCLGFLALVHSVKARDQKMAGNLEAARQYGSKAKCYNILAAMWTLVPPLLLLGLVVTGALHLSKLAKDSAAFFSTKFDEEDYN
uniprot
proteins
function
FUNCTION: Required for normal bone mineralization. {ECO:0000269|PubMed:18442316, ECO:0000269|PubMed:20838829, ECO:0000269|PubMed:24058703, ECO:0000269|PubMed:24715519}.
uniprot
proteins
mass_dalton
14667
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="S->L: Abolishes expression at the cell membrane."; /evidence="ECO:0000269|PubMed:24715519"; MUTAGEN 52; /note="C->A: Strongly reduces expression at the cell membrane. Reduces palmitoylation; when associated with A-53. Abolishes palmitoylation; when associated with A-53 and A-86."; /evidence="ECO:0000269|PubMed:24058703, ECO:0000269|PubMed:24715519"; MUTAGEN 53; /note="C->A: Strongly reduces expression at the cell membrane. Reduces palmitoylation; when associated with A-52. Abolishes palmitoylation; when associated with A-52 and A-86."; /evidence="ECO:0000269|PubMed:24058703, ECO:0000269|PubMed:24715519"; MUTAGEN 86; /note="C->A: No effect on location at the cell membrane. Abolishes palmitoylation; when associated with A-52 and A-53."; /evidence="ECO:0000269|PubMed:24058703, ECO:0000269|PubMed:24715519
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. {ECO:0000269|PubMed:24058703, ECO:0000269|PubMed:24715519}.
uniprot
proteins
protein_family
CD225/Dispanin family
uniprot
proteins
pubmed
11106657
uniprot
proteins
pubmed
12659663
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18442316
uniprot
proteins
pubmed
20838829
uniprot
proteins
pubmed
22363774
uniprot
proteins
pubmed
24058703
uniprot
proteins
pubmed
24715519
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18442316, ECO:0000269|PubMed:24715519}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:18442316}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 89..109; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins