Sh2b1
entrez
20399
canonical
uniprot
Q91ZM2
canonical
ensembl
ENSMUSG00000030733
resolver
ensp
ENSMUSP00000032978
resolver
ensp
ENSMUSP00000145554
resolver
ensp
ENSMUSP00000145754
resolver
ensp
ENSMUSP00000145842
resolver
ensp
ENSMUSP00000145953
resolver
ensp
ENSMUSP00000146282
resolver
ensp
ENSMUSP00000293471
resolver
ensp
ENSMUSP00000293473
resolver
ensp
ENSMUSP00000293474
resolver
ensp
ENSMUSP00000293483
resolver
ensp
ENSMUSP00000293485
resolver
ensp
ENSMUSP00000293490
resolver
ensp
ENSMUSP00000293499
resolver
genesymbol
Sh2b1
resolver
genesymbol_syn
Sh2bpsm1
resolver
uniprot
O54867
resolver
uniprot
Q05DJ7
resolver
uniprot
Q792R7
resolver
uniprot
Q91ZM3
resolver
uniprot
Q91ZV5
resolver
uniprot
Q9WVM5
resolver
uniprot_entry
SH2B1_MOUSE
resolver
uniprot_sec
O54867
resolver
uniprot_sec
Q05DJ7
resolver
uniprot_sec
Q792R7
resolver
uniprot_sec
Q91ZM3
resolver
uniprot_sec
Q91ZV5
resolver
uniprot_sec
Q9WVM5
resolver
amino_acid_sequence
MNGAPSPEDGVFPSPPALPPPPPPSWQEFCESHARAAALDLARRFRLYLASHPQYAEPGAEAAFSGRFAELFLQHFEAEVARASGSLSPPVLAPLSPGVEIPPSHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVPSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGAVDSPSQAGPLETTSGPPVLGGNSNSNSSGGAGTVGRALANDGTSPGERWTHRFERLRLSRGGGTLKDGAGMIQREELLSFMGAEEAAPDPAGVGRGGGAAGLTSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSTITDVRTATALEMPDRENTFVVKVEGPSEYILETSDALHVKAWVSDIQECLSPGPCPAISPRPMTLPLAPGTSFFTKDNTDSLELPCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASFSPSSASIAASHFDSMELLPPELPPRIPIEEGPPAGTVHPLSTPYPPLDTPEAATGSFLFQGESEGGEGDQPLSGYPWFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSQRQQERSTSRDPAQPSEPPPWTDPPHPGAEEASGAPEVAAATAAAAKERQEKEKAGSGGVQEELVPVAELVPMVELEEAIAPGTEAQGGAGSSGDLEVSLMVQLQQLPLGGNGEEGGHPRAINNQYSFV
uniprot
proteins
function
FUNCTION: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor 1 (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as a positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity (By similarity). Isoforms seem to be differentially involved in IGF1 and PDGF-induced mitogenesis, according the order: isoform 3 > isoform 4 > isoform 1 > isoform 2. {ECO:0000250|UniProtKB:Q9NRF2, ECO:0000269|PubMed:11502739, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:16098827, ECO:0000269|PubMed:9343427}.
uniprot
proteins
mass_dalton
79625
uniprot
proteins
mutagenesis
MUTAGEN 555; /note="R->E: Significantly reduced interaction with IRS1."; /evidence="ECO:0000269|PubMed:15316008
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues in response to IGF-I and PDGF stimulation. {ECO:0000269|PubMed:11502739}.
uniprot
proteins
protein_family
SH2B adapter family
uniprot
proteins
pubmed
10594240
uniprot
proteins
pubmed
11502739
uniprot
proteins
pubmed
15316008
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16098827
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16824542
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
9343427
uniprot
proteins
pubmed
9452421
uniprot
proteins
pubmed
9498552
uniprot
proteins
sequence_length
756
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000305}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
uniprot
proteins