Cd48
entrez
245962
canonical
uniprot
P10252
canonical
ensembl
ENSRNOG00000004737
resolver
ensembl
ENSRNOG00055022901
resolver
ensembl
ENSRNOG00060018849
resolver
ensembl
ENSRNOG00065024081
resolver
ensp
ENSRNOP00000006306
resolver
ensp
ENSRNOP00000110512
resolver
ensp
ENSRNOP00055031922
resolver
ensp
ENSRNOP00060026637
resolver
ensp
ENSRNOP00065033781
resolver
enst
ENSRNOT00000006306
resolver
enst
ENSRNOT00000156460
resolver
enst
ENSRNOT00055039343
resolver
enst
ENSRNOT00060032634
resolver
enst
ENSRNOT00065041358
resolver
genesymbol
Cd48
resolver
genesymbol_syn
Bcm-1
resolver
uniprot
A0A8L2Q3B4
resolver
uniprot_entry
A0A8L2Q3B4_RAT
resolver
uniprot_entry
CD48_RAT
resolver
amino_acid_sequence
MYFKKRRWFLILESLLLSLVTGFQDQSVPNVNAITGSNVTLTILKHPLASYQRLTWLHTTNQKILEYFPNGKKTVFESVFKDRVDLDKTNGALRIYNVSKEDRGDYYMRMLHETEDQWKITMEVYDLVSKPAIKIEKTKNLTDSCHLRLSCKVEDQGVDYTWYEDSGPFPQRNPGYVLEITITPHNKSTFYTCQVSNPVSSENDTLYFIPPCTLARSSGVHWIAAWLVVTLSIIPSILLA
uniprot
proteins
function
FUNCTION: Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. {ECO:0000250|UniProtKB:P09326}.
uniprot
proteins
mass_dalton
27680
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16803907
uniprot
proteins
pubmed
3181129
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:3181129}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:3181129}. Membrane raft {ECO:0000250|UniProtKB:P09326}. Secreted {ECO:0000250|UniProtKB:P09326}.
uniprot
proteins