Pmaip1
entrez
492821
canonical
uniprot
Q5U777
canonical
ensembl
ENSRNOG00055010597
resolver
ensp
ENSRNOP00055014437
resolver
enst
ENSRNOT00055017933
resolver
genesymbol
Pmaip1
resolver
genesymbol_syn
Noxa
resolver
uniprot_entry
APR_RAT
resolver
amino_acid_sequence
MPGRKARRNAPLNPTRAELPPEFAAQLRKIGDKVYCTWSAPDITAVLAQMPGKKSRKSTMRRSPSPTRVPADLKDECDQLRRIGDKVNLRQKLLNFISKLFNLIT
uniprot
proteins
function
FUNCTION: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
11901
uniprot
proteins
protein_family
PMAIP1 family
uniprot
proteins
sequence_length
105
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q13794}.
uniprot
proteins