SCUBE2
entrez
57758
canonical
uniprot
Q9NQ36
canonical
ensembl
ENSG00000175356
resolver
ensp
ENSP00000310658
resolver
ensp
ENSP00000415187
resolver
ensp
ENSP00000429969
resolver
ensp
ENSP00000497523
resolver
ensp
ENSP00000569152
resolver
ensp
ENSP00000569153
resolver
ensp
ENSP00000569156
resolver
ensp
ENSP00000569157
resolver
ensp
ENSP00000620301
resolver
ensp
ENSP00000620306
resolver
ensp
ENSP00000620307
resolver
enst
ENST00000649792
resolver
genesymbol
SCUBE2
resolver
genesymbol_syn
CEGP1
resolver
hgnc
HGNC:30425
resolver
uniprot
A0A3B3ISZ7
resolver
uniprot
B3KS09
resolver
uniprot
Q2NKQ8
resolver
uniprot
Q6ZWI1
resolver
uniprot_entry
A0A3B3ISZ7_HUMAN
resolver
uniprot_entry
B3KS09_HUMAN
resolver
uniprot_entry
SCUB2_HUMAN
resolver
uniprot_sec
Q2NKQ8
resolver
uniprot_sec
Q6ZWI1
resolver
amino_acid_sequence
MGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFACACNRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPEKHSSVKESFRYVNLTCSSGKQVPGAPGRPSTPKEMFITVEFELETNQKEVTASCDLSCIVKRTEKRLRKAIRTLRKAVHREQFHLQLSGMNLDVAKKPPRTSERQAESCGVGQGHAENQCVSCRAGTYYDGARERCILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTTHRCIRCPVGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQCKNRRCGGELGDFTGYIESPNYPGNYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCGDYLVMRKTSSSNSVTTYETCQTYERPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVTYDEDYQELIEDIVRDGRLYASENHQEILKDKKLIKALFDVLAHPQNYFKYTAQESREMFPRSFIRLLRSKVSRFLRPYK
uniprot
proteins
function
FUNCTION: Lipid-binding protein carrier required for sonic hedgehog (SHH) long-range signaling: binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) and promotes its release from producing cells, allowing it to act as a morphogen for distant signaling (PubMed:19480626, PubMed:22677548, PubMed:22902404, PubMed:35231446). ShhN is then transferred to the CDON-BOC heterodimer and GAS1 coreceptors to reach its target, the patched receptor (PTCH1 or PTCH2), followed by activation of the smoothened signaling pathway (PubMed:35231446). May also enhance the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687). {ECO:0000269|PubMed:19480626, ECO:0000269|PubMed:22677548, ECO:0000269|PubMed:22902404, ECO:0000269|PubMed:24522195, ECO:0000269|PubMed:27834687, ECO:0000269|PubMed:35231446}.
uniprot
proteins
mass_dalton
109957
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:19480626}.
uniprot
proteins
pubmed
11528127
uniprot
proteins
pubmed
12270931
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
19480626
uniprot
proteins
pubmed
22677548
uniprot
proteins
pubmed
22902404
uniprot
proteins
pubmed
24522195
uniprot
proteins
pubmed
26875496
uniprot
proteins
pubmed
27834687
uniprot
proteins
pubmed
33308444
uniprot
proteins
pubmed
35231446
uniprot
proteins
sequence_length
999
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19480626}. Cell surface {ECO:0000269|PubMed:19480626}. Note=Secreted and tethered at the cell surface. {ECO:0000269|PubMed:19480626}.
uniprot
proteins