E2F7
entrez
144455
canonical
uniprot
Q96AV8
canonical
ensembl
ENSG00000165891
resolver
ensp
ENSP00000323246
resolver
ensp
ENSP00000589505
resolver
genesymbol
E2F7
resolver
hgnc
HGNC:23820
resolver
uniprot
A6NC74
resolver
uniprot
B2RMR7
resolver
uniprot
B3KTZ5
resolver
uniprot
B3KUP8
resolver
uniprot
B5MED9
resolver
uniprot_entry
E2F7_HUMAN
resolver
uniprot_sec
A6NC74
resolver
uniprot_sec
B2RMR7
resolver
uniprot_sec
B3KTZ5
resolver
uniprot_sec
B3KUP8
resolver
uniprot_sec
B5MED9
resolver
amino_acid_sequence
MEVNCLTLKDLISPRQPRLDFAVEDGENAQKENIFVDRSRMAPKTPIKNEPIDLSKQKKFTPERNPITPVKFVDRQQAEPWTPTANLKMLISAASPDIRDREKKKGLFRPIENKDDAFTDSLQLDVVGDSAVDEFEKQRPSRKQKSLGLLCQKFLARYPSYPLSTEKTTISLDEVAVSLGVERRRIYDIVNVLESLHLVSRVAKNQYGWHGRHSLPKTLRNLQRLGEEQKYEEQMAYLQQKELDLIDYKFGERKKDGDPDSQEQQLLDFSEPDCPSSSANSRKDKSLRIMSQKFVMLFLVSKTKIVTLDVAAKILIEESQDAPDHSKFKTKVRRLYDIANVLTSLALIKKVHVTEERGRKPAFKWIGPVDFSSSDEELVDVSASVLPELKRETYGQIQVCAKQKLARHGSFNTVQASERIQRKVNSEPSSPYREEQGSGGYSLEIGSLAAVYRQKIEDNSQGKAFASKRVVPPSSSLDPVAPFPVLSVDPEYCVNPLAHPVFSVAQTDLQAFSMQNGLNGQVDVSLASAASAVESLKPALLAGQPLVYVPSASLFMLYGSLQEGPASGSGSERDDRSSEAPATVELSSAPSAQKRLCEERKPQEEDEPATKRQSREYEDGPLSLVMPKKPSDSTDLASPKTMGNRASIPLKDIHVNGQLPAAEEISGKATANSLVSSEWGNPSRNTDVEKPSKENESTKEPSLLQYLCVQSPAGLNGFNVLLSGSQTPPTVGPSSGQLPSFSVPCMVLPSPPLGPFPVLYSPAMPGPVSSTLGALPNTGPVNFSLPGLGSIAQLLVGPTAVVNPKSSTLPSADPQLQSQPSLNLSPVMSRSHSVVQQPESPVYVGHPVSVVKLHQSPVPVTPKSIQRTHRETFFKTPGSLGDPVLKRRERNQSRNTSSAQRRLEIPSGGAD
uniprot
proteins
function
FUNCTION: Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation. {ECO:0000269|PubMed:14633988, ECO:0000269|PubMed:15133492, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:19223542, ECO:0000269|PubMed:21248772, ECO:0000269|PubMed:22802528, ECO:0000269|PubMed:22802529, ECO:0000269|PubMed:22903062}.
uniprot
proteins
mass_dalton
99888
uniprot
proteins
mutagenesis
MUTAGEN 147..148; /note="LG->EE: Loss of DNA-binding and E2F-dependent repression."; /evidence="ECO:0000269|PubMed:14633988"; MUTAGEN 185; /note="R->A: Loss of DNA-binding and inhibition of E2F1-dependent activation. Impairs DNA-binding and dimerization; when associated with A-334."; /evidence="ECO:0000269|PubMed:15133492, ECO:0000269|PubMed:18202719"; MUTAGEN 334; /note="R->A: Loss of DNA-binding and inhibition of E2F1-dependent activation. Impairs DNA-binding and dimerization; when associated with A-185."; /evidence="ECO:0000269|PubMed:15133492, ECO:0000269|PubMed:18202719
uniprot
proteins
protein_family
E2F/DP family
uniprot
proteins
pubmed
14633988
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15133492
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
18194653
uniprot
proteins
pubmed
18202719
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19223542
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21248772
uniprot
proteins
pubmed
22802528
uniprot
proteins
pubmed
22802529
uniprot
proteins
pubmed
22903062
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
31839203
uniprot
proteins
sequence_length
911
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15133492}.
uniprot
proteins