Hdgf
entrez
15191
canonical
uniprot
P51859
canonical
ensembl
ENSMUSG00000004897
resolver
ensp
ENSMUSP00000005017
resolver
ensp
ENSMUSP00000124803
resolver
enst
ENSMUST00000005017
resolver
genesymbol
Hdgf
resolver
genesymbol_syn
Tdrm1
resolver
uniprot
Q8BPG7
resolver
uniprot
Q9CYA4
resolver
uniprot
Q9JK87
resolver
uniprot_entry
HDGF_MOUSE
resolver
uniprot_sec
Q8BPG7
resolver
uniprot_sec
Q9CYA4
resolver
uniprot_sec
Q9JK87
resolver
amino_acid_sequence
MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCAAEPEVEPEAHEGDGDKKGSAEGSSDEEGKLVIDEPAKEKNEKGTLKRRAGDVLEDSPKRPKESGDHEEEDKEIAALEGERPLPVEVEKNSTPSEPDSGQGPPAEEEEGEEEAAKEEAEAQGVRDHESL
uniprot
proteins
function
FUNCTION: Acts as a transcriptional repressor (By similarity). Has mitogenic activity for fibroblasts (By similarity). Heparin-binding protein (By similarity). {ECO:0000250|UniProtKB:P51858}.
uniprot
proteins
mass_dalton
26269
uniprot
proteins
mutagenesis
MUTAGEN 12; /note="C->A: Abolishes disulfide bond formation."; /evidence="ECO:0000269|PubMed:21087088"; MUTAGEN 98; /note="S->A: Does not affect secretion."; /evidence="ECO:0000269|PubMed:21087088"; MUTAGEN 102..103; /note="SS->AA: Does not affect secretion."; /evidence="ECO:0000269|PubMed:21087088"; MUTAGEN 108; /note="C->A: Abolishes disulfide bond formation."; /evidence="ECO:0000269|PubMed:21087088"; MUTAGEN 128; /note="S->A: Does not affect secretion."; /evidence="ECO:0000269|PubMed:21087088"; MUTAGEN 132; /note="S->A: Does not affect secretion."; /evidence="ECO:0000269|PubMed:21087088"; MUTAGEN 133; /note="S->A: Does not affect secretion."; /evidence="ECO:0000269|PubMed:21087088"; MUTAGEN 165; /note="S->A: Abolishes secretion."; /evidence="ECO:0000269|PubMed:21087088"; MUTAGEN 202; /note="S->A: Does not affect secretion."; /evidence="ECO:0000269|PubMed:21087088"; MUTAGEN 206; /note="S->A: Does not affect secretion."; /evidence="ECO:0000269|PubMed:21087088
uniprot
proteins
post_translational_modification
PTM: Sumoylated with SUMO1. Sumoylation prevents binding to chromatin. {ECO:0000250|UniProtKB:P51858}.; PTM: Phosphorylation at Ser-165 is likely to be required for secretion. {ECO:0000269|PubMed:21087088}.
uniprot
proteins
protein_family
HDGF family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17622165
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21087088
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9299445
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P51858}. Cytoplasm {ECO:0000250|UniProtKB:P51858}. Secreted, extracellular exosome {ECO:0000269|PubMed:21087088}. Note=Secreted by exosomes and is located inside the exosome (By similarity). May also be secreted as free protein via an as yet unknown pathway (By similarity). {ECO:0000250|UniProtKB:P51858}.
uniprot
proteins