Atf1
entrez
11908
canonical
uniprot
P81269
canonical
ensembl
ENSMUSG00000023027
resolver
ensp
ENSMUSP00000023769
resolver
ensp
ENSMUSP00000284793
resolver
ensp
ENSMUSP00000284795
resolver
enst
ENSMUST00000023769
resolver
genesymbol
Atf1
resolver
uniprot
Q9CWS2
resolver
uniprot_entry
ATF1_MOUSE
resolver
uniprot_entry
Q9CWS2_MOUSE
resolver
amino_acid_sequence
MEDSHKSNTTETASQPGSTVAGPHVSQIVHQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGEGENPSISAITSMSVPAPIYQTSSGQYIAIAPNGALQLASPSTDGVQALQTLTMTNSSSTQQGTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLASQTTKTDDPQLRREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSHKSV
uniprot
proteins
function
FUNCTION: Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
29238
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-196 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities (By similarity). Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. {ECO:0000250, ECO:0000269|PubMed:18690222}.
uniprot
proteins
protein_family
ATF subfamily
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
1531847
uniprot
proteins
pubmed
18690222
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1531847}.
uniprot
proteins