TACR2
entrez
6865
canonical
uniprot
P21452
canonical
ensembl
ENSG00000075073
resolver
ensp
ENSP00000362403
resolver
enst
ENST00000373306
resolver
genesymbol
TACR2
resolver
genesymbol_syn
NK2R
resolver
genesymbol_syn
NKNAR
resolver
genesymbol_syn
TAC2R
resolver
hgnc
HGNC:11527
resolver
uniprot
A8K7I1
resolver
uniprot
Q4QRI5
resolver
uniprot
Q8NGQ8
resolver
uniprot
Q9UDE6
resolver
uniprot
Q9UDE7
resolver
uniprot_entry
NK2R_HUMAN
resolver
uniprot_sec
A8K7I1
resolver
uniprot_sec
Q4QRI5
resolver
uniprot_sec
Q8NGQ8
resolver
uniprot_sec
Q9UDE6
resolver
uniprot_sec
Q9UDE7
resolver
amino_acid_sequence
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
uniprot
proteins
function
FUNCTION: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A) (PubMed:1659297, PubMed:1848773). Is also able to bind and respond to tachynins substance P and neurokinin B/neuromedin-K (By similarity). The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P (By similarity). Substance K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (PubMed:7957923, PubMed:35882833). Substance K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity). {ECO:0000250|UniProtKB:P30549, ECO:0000269|PubMed:1659297, ECO:0000269|PubMed:1848773, ECO:0000269|PubMed:35882833, ECO:0000269|PubMed:7957923}.
uniprot
proteins
mass_dalton
44442
uniprot
proteins
mutagenesis
MUTAGEN 28; /note="M->A: Reduced response to NKA."; /evidence="ECO:0000269|PubMed:35882833"; MUTAGEN 93; /note="Y->A: Reduced response to NKA."; /evidence="ECO:0000269|PubMed:35882833"; MUTAGEN 97; /note="N->A: Severely reduced response to NKA."; /evidence="ECO:0000269|PubMed:35882833"; MUTAGEN 114; /note="I->G: Reduced response to NKA."; /evidence="ECO:0000269|PubMed:35882833"; MUTAGEN 175; /note="D->A: Reduced response to NKA."; /evidence="ECO:0000269|PubMed:35882833"; MUTAGEN 285; /note="I->A: Reduced response to NKA."; /evidence="ECO:0000269|PubMed:35882833"; MUTAGEN 289; /note="Y->A: Reduced response to NKA."; /evidence="ECO:0000269|PubMed:35882833
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1659296
uniprot
proteins
pubmed
1659297
uniprot
proteins
pubmed
1710456
uniprot
proteins
pubmed
1845990
uniprot
proteins
pubmed
1848773
uniprot
proteins
pubmed
2173708
uniprot
proteins
pubmed
35882833
uniprot
proteins
pubmed
37968728
uniprot
proteins
pubmed
7957923
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37968728}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..56; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 70..90; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 108..129; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 197..218; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 252..272; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 291..310; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins