PHF13
entrez
148479
canonical
uniprot
Q86YI8
canonical
ensembl
ENSG00000116273
resolver
ensp
ENSP00000366876
resolver
enst
ENST00000377648
resolver
genesymbol
PHF13
resolver
genesymbol
SPOC1
resolver
hgnc
HGNC:22983
resolver
uniprot
A0A158RFV6
resolver
uniprot
B3KUQ7
resolver
uniprot
Q59FB6
resolver
uniprot
Q5TH65
resolver
uniprot
Q8N551
resolver
uniprot
Q9UJP2
resolver
uniprot_entry
A0A158RFV6_HUMAN
resolver
uniprot_entry
PHF13_HUMAN
resolver
uniprot_sec
B3KUQ7
resolver
uniprot_sec
Q59FB6
resolver
uniprot_sec
Q5TH65
resolver
uniprot_sec
Q8N551
resolver
uniprot_sec
Q9UJP2
resolver
amino_acid_sequence
MDSDSCAAAFHPEEYSPSCKRRRTVEDFNKFCTFVLAYAGYIPYPKEELPLRSSPSPANSTAGTIDSDGWDAGFSDIASSVPLPVSDRCFSHLQPTLLQRAKPSNFLLDRKKTDKLKKKKKRKRRDSDAPGKEGYRGGLLKLEAADPYVETPTSPTLQDIPQAPSDPCSGWDSDTPSSGSCATVSPDQVKEIKTEGKRTIVRQGKQVVFRDEDSTGNDEDIMVDSDDDSWDLVTCFCMKPFAGRPMIECNECHTWIHLSCAKIRKSNVPEVFVCQKCRDSKFDIRRSNRSRTGSRKLFLD
uniprot
proteins
function
FUNCTION: Modulates chromatin structure and DNA damage response by regulating key determinants of chromatin compaction and DNA damage response (PubMed:19638409). Binds H3K4me3-containing chromatin and promotes DNA condensation by recruiting corepressors such as TRIM28 and H3K9 methyltransferase SETDB1 (PubMed:23034801). Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis (PubMed:19638409). Increases both chromatin-associated levels and activity of H3K9 methyltransferases, such as SETDB1, thus enhancing H3K9 trimethylation (PubMed:23034801). Essential for testicular stem-cell differentiation and sustained spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K2W6, ECO:0000269|PubMed:19638409, ECO:0000269|PubMed:23034801}.
uniprot
proteins
mass_dalton
33582
uniprot
proteins
post_translational_modification
PTM: Subject to proteasomal degradation. Stable when bound to chromatin. The soluble form is rapidly degraded. {ECO:0000269|PubMed:19638409}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19638409
uniprot
proteins
pubmed
23034801
uniprot
proteins
pubmed
32890405
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19638409, ECO:0000269|PubMed:23034801}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19638409}. Note=Predominantly bound to chromatin, but a minor proportion is also detected in the nucleoplasm.
uniprot
proteins