Hrh4
entrez
170704
canonical
uniprot
Q91ZY1
canonical
ensembl
ENSRNOG00000016887
resolver
ensembl
ENSRNOG00055008573
resolver
ensembl
ENSRNOG00060009647
resolver
ensembl
ENSRNOG00065006645
resolver
ensp
ENSRNOP00000022744
resolver
ensp
ENSRNOP00055011571
resolver
ensp
ENSRNOP00060012704
resolver
ensp
ENSRNOP00065007503
resolver
enst
ENSRNOT00000022744
resolver
enst
ENSRNOT00055014473
resolver
enst
ENSRNOT00060016272
resolver
enst
ENSRNOT00065010270
resolver
genesymbol
Hrh4
resolver
uniprot
G3V868
resolver
uniprot_entry
G3V868_RAT
resolver
uniprot_entry
HRH4_RAT
resolver
amino_acid_sequence
MSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor primarily expressed in immune cells such as mast cells, eosinophils, basophils, dendritic cells and neutrophils that plays a key role in immune and inflammatory responses. Mediates chemotaxis of immune cells to sites of inflammation or injury by responding to histamine. Activation by histamine also influences the release of proinflammatory cytokines such as TNF, CCL4, IL6 and IFN-gamma (PubMed:31863333). Ligand binding induces a conformation change that triggers signaling via G(i)/GNAI1 leading to decreased intracellular cAMP levels by inhibiting adenylate cyclase activity (By similarity). In addition, plays a role in the control of renal reabsorption processes, particularly albumin uptake (By similarity). {ECO:0000250|UniProtKB:Q91ZY2, ECO:0000250|UniProtKB:Q9H3N8, ECO:0000269|PubMed:31863333}.
uniprot
proteins
mass_dalton
44023
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
31863333
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H3N8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H3N8}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 132..152; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 175..195; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 307..327; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins