Rasgrf2
entrez
19418
canonical
uniprot
P70392
canonical
ensembl
ENSMUSG00000021708
resolver
ensp
ENSMUSP00000116892
resolver
ensp
ENSMUSP00000169857
resolver
enst
ENSMUST00000151408
resolver
genesymbol
Rasgrf2
resolver
genesymbol_syn
Grf2
resolver
uniprot
Q3TYN3
resolver
uniprot
Q9QX51
resolver
uniprot_entry
RGRF2_MOUSE
resolver
uniprot_sec
Q3TYN3
resolver
uniprot_sec
Q9QX51
resolver
amino_acid_sequence
MQKSVRYNEGHALYLAMLARKEGTKRGFLSKKAAEASRWHEKWFALYQNVLFYFEGEQSGRPAGMYLLEGCSCERTPAPPRTNAGPAGARDALDKQYYFTVLFGHDGQKPLELRCEEEQAGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIATNQLRHQLEDQDTEIERLKSEIVALNKTKERMRPYHVHQEEEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAETEYVHQLYILVNGFLRPLRMAASSKKPPINHDDVSSIFLNSETIMFLHEIFHQGLKARLANWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIQCTLIEEPDGSDDDPKGSGHMFGHLDFKIVVEPPDAASFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTATVVLAKLSDIYKRPFTSIPVRSLELFFATSQNNREHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSSLNSRIGALDLTNSSSSSSPTTTTHSPAASPPPHTAVLESAPADKAGDSADMSPCRSPTTPRHLRYRQPGGQVADSAHCSVSPASAFAIATAAAGHGSPPGFNNERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKATANILRALSQDDQDDIHLKLEDIIQMTDCPKAECFETLSAMELAEQITLLDHIVFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNEMSNLVASQIMNYADISSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTAYRIDQQPKVIQYLLDKALVIDEDSLYELSLKIEPRLPA
uniprot
proteins
function
FUNCTION: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:10733575, ECO:0000269|PubMed:11500499, ECO:0000269|PubMed:14749369, ECO:0000269|PubMed:15029245, ECO:0000269|PubMed:16407208, ECO:0000269|PubMed:16467520, ECO:0000269|PubMed:9032266, ECO:0000269|PubMed:9707409}.
uniprot
proteins
mass_dalton
135668
uniprot
proteins
mutagenesis
MUTAGEN 1022; /note="R->E: Loss of interaction with Ras. Loss of Ras activation. Loss of ubiquitination."; /evidence="ECO:0000269|PubMed:11238945"; MUTAGEN 1092; /note="R->E: Partial loss of interaction with Ras. Partial loss of Ras activation. Partial loss of ubiquitination."; /evidence="ECO:0000269|PubMed:11238945
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK5; down-regulates RASGRF2-mediated RAC1 activation. {ECO:0000269|PubMed:11238945, ECO:0000269|PubMed:15128856}.; PTM: Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome. {ECO:0000269|PubMed:11238945}.
uniprot
proteins
pubmed
10373510
uniprot
proteins
pubmed
10733575
uniprot
proteins
pubmed
11238945
uniprot
proteins
pubmed
11500499
uniprot
proteins
pubmed
11856323
uniprot
proteins
pubmed
11909944
uniprot
proteins
pubmed
14749369
uniprot
proteins
pubmed
15029245
uniprot
proteins
pubmed
15128856
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16407208
uniprot
proteins
pubmed
16467520
uniprot
proteins
pubmed
16649990
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9032266
uniprot
proteins
pubmed
9707409
uniprot
proteins
sequence_length
1189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity). {ECO:0000250}.
uniprot
proteins