Nr1h3
entrez
22259
canonical
uniprot
Q9Z0Y9
canonical
ensembl
ENSMUSG00000002108
resolver
ensp
ENSMUSP00000002177
resolver
ensp
ENSMUSP00000106986
resolver
ensp
ENSMUSP00000106988
resolver
ensp
ENSMUSP00000171777
resolver
ensp
ENSMUSP00000171792
resolver
ensp
ENSMUSP00000328119
resolver
enst
ENSMUST00000002177
resolver
enst
ENSMUST00000111354
resolver
enst
ENSMUST00000111356
resolver
genesymbol
Nr1h3
resolver
genesymbol_syn
Lxra
resolver
uniprot
Q91X41
resolver
uniprot
Q9QUH7
resolver
uniprot_entry
NR1H3_MOUSE
resolver
uniprot_entry
Q91X41_MOUSE
resolver
uniprot_sec
Q9QUH7
resolver
amino_acid_sequence
MSLWLEASMPDVSPDSATELWKTEPQDAGDQGGNTCILREEARMPQSTGVALGIGLESAEPTALLPRAETLPEPTELRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGARYVCHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAQATSVSPRVSSPPQVLPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPIAPDPQSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSINHPHDPLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
uniprot
proteins
function
FUNCTION: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (PubMed:25806685, PubMed:28846071). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (PubMed:25806685). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (PubMed:24206663). {ECO:0000250|UniProtKB:Q13133, ECO:0000269|PubMed:18055760, ECO:0000269|PubMed:19520913, ECO:0000269|PubMed:20427281, ECO:0000269|PubMed:24206663, ECO:0000269|PubMed:25806685, ECO:0000269|PubMed:28846071}.
uniprot
proteins
mass_dalton
50418
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated (PubMed:27383786). Ubiquitination by UBR5 leads to its degradation: UBR5 specifically recognizes and binds ligand-bound NR1H3 when it is not associated with coactivators (NCOAs) (By similarity). In presence of NCOAs, the UBR5-degron is not accessible, preventing its ubiquitination and degradation (By similarity). {ECO:0000250|UniProtKB:Q13133, ECO:0000269|PubMed:27383786}.
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10675617
uniprot
proteins
pubmed
10890879
uniprot
proteins
pubmed
16107141
uniprot
proteins
pubmed
18055760
uniprot
proteins
pubmed
18800767
uniprot
proteins
pubmed
19167885
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19520913
uniprot
proteins
pubmed
20427281
uniprot
proteins
pubmed
24206663
uniprot
proteins
pubmed
25806685
uniprot
proteins
pubmed
27383786
uniprot
proteins
pubmed
28846071
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:27383786}. Cytoplasm {ECO:0000269|PubMed:27383786}.
uniprot
proteins