Ndnf
entrez
68169
canonical
uniprot
Q8C119
canonical
ensembl
ENSMUSG00000049001
resolver
ensp
ENSMUSP00000051297
resolver
ensp
ENSMUSP00000310980
resolver
enst
ENSMUST00000054351
resolver
genesymbol
Ndnf
resolver
uniprot
Q80VN3
resolver
uniprot
Q8BWV6
resolver
uniprot_entry
NDNF_MOUSE
resolver
uniprot_sec
Q80VN3
resolver
uniprot_sec
Q8BWV6
resolver
amino_acid_sequence
MELFYWCLLCLLLPLTSRTQKLPTRDEELFQMQIRDKEFFHDSSVIPDGAEVSSYLFRDTPRRYFFMVEEDNTPLSVTVTPCDAPLEWKLSLQELHEGSSADGSGDPELLDQQKQQMTDVEGTELFSYKGNDVEYFLSSSSPSGLYQLELLSTEKDTHFKVYATTTPESDQPYPELPYDPRVDVTSFGRTTVTLAWKPSPTASILKQPIEYCVVINKEHNFKSLCAAETKMNADDAFMVAPKPGLDFNPFDFAHFGFPTDNLGKDRSLLAKPSPKVGRHVYWRPKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFMVNTNTNMSTAYVGAFVRTKEEAKQKTVELKDGRVTDVFVKRKGKKFLRFAPVSSHQKVTFFIHSCMDAVQVQVRRDGRLLLSQNVEGIRQFQLRGKPKGKYLIRLKGNRKGASKLKILATTRPSKHAFPSLPEDTRIKAFDKLRTCSSVTVAWLGTQERRKFCIYRKEVDGNYSEDQKRREQNQCLGPDTRKKSEKVLCKYFHSQNLQKAVTTETIRDLQPGKSYLLDVYVVGHGGHSVKYQSKIVKTRKVC
uniprot
proteins
function
FUNCTION: Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645). Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system (PubMed:31883645). May also act through the regulation of growth factors activity and downstream signaling (By similarity). Also regulates extracellular matrix assembly and cell adhesiveness (PubMed:18757743). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764). {ECO:0000250|UniProtKB:Q8TB73, ECO:0000269|PubMed:18757743, ECO:0000269|PubMed:24706764, ECO:0000269|PubMed:31883645}.
uniprot
proteins
mass_dalton
65027
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains heparan sulfate and chondroitin sulfate. {ECO:0000269|PubMed:20969804}.; PTM: N-glycosylated. {ECO:0000269|PubMed:20969804}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18757743
uniprot
proteins
pubmed
20969804
uniprot
proteins
pubmed
24706764
uniprot
proteins
pubmed
31883645
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18757743}.
uniprot
proteins