SST
entrez
6750
canonical
uniprot
P61278
canonical
ensembl
ENSG00000157005
resolver
ensp
ENSP00000287641
resolver
enst
ENST00000287641
resolver
genesymbol
SST
resolver
hgnc
HGNC:11329
resolver
uniprot
B2R5G3
resolver
uniprot
P01166
resolver
uniprot_entry
SMS_HUMAN
resolver
uniprot_sec
B2R5G3
resolver
uniprot_sec
P01166
resolver
amino_acid_sequence
MLSCRLQCALAALSIVLALGCVTGAPSDPRLRQFLQKSLAAAAGKQELAKYFLAELLSEPNQTENDALEPEDLSQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC
uniprot
proteins
function
FUNCTION: [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. {ECO:0000269|PubMed:29615476}.; FUNCTION: [Neuronostatin]: May enhance low-glucose-induced glucagon release by pancreatic alpha cells (By similarity). This effect may be mediated by binding to GPR107 and PKA activation (By similarity). May regulate cardiac contractile function (By similarity). May compromise cardiomyocyte viability (By similarity). In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity). May also have anxiolytic and anorexigenic effects (By similarity). May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (PubMed:29615476). {ECO:0000250|UniProtKB:P60041, ECO:0000250|UniProtKB:P60042, ECO:0000269|PubMed:29615476}.
uniprot
proteins
mass_dalton
12736
uniprot
proteins
post_translational_modification
PTM: C-terminal amidation of the neuronostatin peptide is required for its biological activity, including for the regulation of mean arterial pressure. {ECO:0000250|UniProtKB:P60042}.
uniprot
proteins
protein_family
Somatostatin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29615476
uniprot
proteins
pubmed
6126875
uniprot
proteins
pubmed
6142531
uniprot
proteins
sequence_length
116
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60042}.
uniprot
proteins