KDM4C
entrez
23081
canonical
uniprot
Q9H3R0
canonical
ensembl
ENSG00000107077
resolver
ensp
ENSP00000370710
resolver
ensp
ENSP00000383990
resolver
ensp
ENSP00000405739
resolver
ensp
ENSP00000445427
resolver
ensp
ENSP00000541120
resolver
ensp
ENSP00000618739
resolver
ensp
ENSP00000794426
resolver
ensp
ENSP00000794427
resolver
enst
ENST00000401787
resolver
genesymbol
KDM4C
resolver
genesymbol_syn
GASC1
resolver
genesymbol_syn
JHDM3C
resolver
genesymbol_syn
JMJD2C
resolver
genesymbol_syn
KIAA0780
resolver
hgnc
HGNC:17071
resolver
uniprot
B0QZ60
resolver
uniprot
B4E1Y4
resolver
uniprot
B7ZL46
resolver
uniprot
F5H347
resolver
uniprot
F5H7P0
resolver
uniprot
O94877
resolver
uniprot
Q2M3M0
resolver
uniprot
Q5JUC9
resolver
uniprot
Q5VYJ2
resolver
uniprot
Q5VYJ3
resolver
uniprot_entry
B0QZ60_HUMAN
resolver
uniprot_entry
KDM4C_HUMAN
resolver
uniprot_sec
B4E1Y4
resolver
uniprot_sec
B7ZL46
resolver
uniprot_sec
F5H347
resolver
uniprot_sec
F5H7P0
resolver
uniprot_sec
O94877
resolver
uniprot_sec
Q2M3M0
resolver
uniprot_sec
Q5JUC9
resolver
uniprot_sec
Q5VYJ2
resolver
uniprot_sec
Q5VYJ3
resolver
amino_acid_sequence
MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLEPGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQGERKRQRVLSSRFKNEYVADPVYRTFLKSSFQKKCQKRQ
uniprot
proteins
ec_number
1.14.11.66
uniprot
proteins
function
FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.
uniprot
proteins
mass_dalton
119982
uniprot
proteins
mutagenesis
MUTAGEN 190..192; /note="HTE->ATA: Abolishes lysine-specific histone demethylase activity."; /evidence="ECO:0000269|PubMed:28262558
uniprot
proteins
protein_family
JHDM3 histone demethylase family
uniprot
proteins
pubmed
10987278
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16603238
uniprot
proteins
pubmed
21914792
uniprot
proteins
pubmed
28262558
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
1056
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.
uniprot
proteins