Akap7
entrez
361458
canonical
uniprot
Q6JP77
canonical
ensembl
ENSRNOG00000013202
resolver
ensp
ENSRNOP00000084444
resolver
ensp
ENSRNOP00000100637
resolver
enst
ENSRNOT00000139387
resolver
genesymbol
Akap7
resolver
genesymbol_syn
Akap18
resolver
uniprot
A0ABK0LH41
resolver
uniprot
D3ZMQ5
resolver
uniprot_entry
A0ABK0LH41_RAT
resolver
uniprot_entry
AKA7G_RAT
resolver
uniprot_sec
D3ZMQ5
resolver
amino_acid_sequence
MERPAAGEIDANKCDHLSRGEEGTGDLETSPVGSLADLPFAAVDIQDDCGLPDVPQGNVPQGNPKRSKENRGDRNDHVKKRKKAKKDYQPNYFLSIPITNKKITAGIKVLQNSILRQDNRLTKAMVGDGSFHITLLVMQLLNEDEVNIGTDALLELKPFVEEILEGKHLTLPFHGIGTFQGQVGFVKLADGDHVSALLEIAETAKRTFQEKGILAGESRTFKPHLTFMKLSKAPMLWKKGVRKIEPGLYEQFIDHRFGEEILYQIDLCSMLKKKQSNGYYHCESSIVIGEKDRKEPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGEGNSVKAEEGDRNGDGSDNNRK
uniprot
proteins
function
FUNCTION: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium (By similarity). Isoform Delta may be involved in shuttling aquaporin-2 (AQP2) to the plasma membrane. {ECO:0000250|UniProtKB:Q9P0M2, ECO:0000269|PubMed:15037626, ECO:0000305}.
uniprot
proteins
mass_dalton
39418
uniprot
proteins
mutagenesis
MUTAGEN 308; /note="L->P: Reduces PKA-RII-alpha binding."; /evidence="ECO:0000269|PubMed:15037626
uniprot
proteins
pubmed
15037626
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18082768
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Gamma]: Nucleus {ECO:0000250|UniProtKB:F8VQ58, ECO:0000250|UniProtKB:Q9P0M2}. Cytoplasm {ECO:0000250|UniProtKB:F8VQ58, ECO:0000250|UniProtKB:Q9P0M2}.; SUBCELLULAR LOCATION: [Isoform Delta]: Nucleus {ECO:0000269|PubMed:15037626}. Cell membrane {ECO:0000269|PubMed:15037626}. Note=Cotranslocates with AQP2 to the plasma membrane in response to arginine-vasopressin (AVP) stimulation in inner medullary collecting duct (IMCD) cells. {ECO:0000269|PubMed:15037626}.
uniprot
proteins