RNF185
entrez
91445
canonical
uniprot
Q96GF1
canonical
ensembl
ENSG00000138942
resolver
ensp
ENSP00000266252
resolver
ensp
ENSP00000320508
resolver
genesymbol
RNF185
resolver
hgnc
HGNC:26783
resolver
uniprot
A8K5C1
resolver
uniprot
A9X3T8
resolver
uniprot
Q8N900
resolver
uniprot_entry
RN185_HUMAN
resolver
uniprot_sec
A8K5C1
resolver
uniprot_sec
A9X3T8
resolver
uniprot_sec
Q8N900
resolver
amino_acid_sequence
MASKGPSASASPENSSAGGPSGSSNGAGESGGQDSTFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPGTPQYVDEQFLSRLFLFVALVIMFWLLIA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693). Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036). Protects cells from ER stress-induced apoptosis (PubMed:27485036). Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521). Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS at 'Lys-173' and 'Lys-384', thereby promoting CGAS cyclic GMP-AMP synthase activity (PubMed:28273161). Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521). {ECO:0000269|PubMed:21931693, ECO:0000269|PubMed:24019521, ECO:0000269|PubMed:27485036, ECO:0000269|PubMed:28273161}.
uniprot
proteins
mass_dalton
20459
uniprot
proteins
mutagenesis
MUTAGEN 39; /note="C->A: Abolished E3 ubiquitin-protein ligase activity and ability to regulate the cGAS-STING pathway; when associated with A-79."; /evidence="ECO:0000269|PubMed:28273161"; MUTAGEN 39; /note="C->S: Decreased ubiquitin ligase activity."; /evidence="ECO:0000269|PubMed:27485036"; MUTAGEN 79; /note="C->A: Abolished E3 ubiquitin-protein ligase activity and ability to regulate the cGAS-STING pathway; when associated with A-39."; /evidence="ECO:0000269|PubMed:28273161
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:21931693, ECO:0000269|PubMed:27485036, ECO:0000269|PubMed:28273161}.
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21931693
uniprot
proteins
pubmed
24019521
uniprot
proteins
pubmed
27485036
uniprot
proteins
pubmed
28273161
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:21931693}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24019521, ECO:0000269|PubMed:27485036}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 131..151; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins