NKD2
entrez
85409
canonical
uniprot
Q969F2
canonical
ensembl
ENSG00000145506
resolver
ensembl
ENSG00000276920
resolver
ensp
ENSP00000274150
resolver
ensp
ENSP00000296849
resolver
ensp
ENSP00000536747
resolver
ensp
ENSP00000658215
resolver
genesymbol
NKD2
resolver
hgnc
HGNC:17046
resolver
uniprot
Q96EK8
resolver
uniprot
Q9BSN0
resolver
uniprot_entry
NKD2_HUMAN
resolver
uniprot_sec
Q96EK8
resolver
uniprot_sec
Q9BSN0
resolver
amino_acid_sequence
MGKLQSKHAAAARKRRESPEGDSFVASAYASGRKGAEEAERRARDKQELPNGDPKEGPFREDQCPLQVALPAEKAEGREHPGQLLSADDGERAANREGPRGPGGQRLNIDALQCDVSVEEDDRQEWTFTLYDFDNCGKVTREDMSSLMHTIYEVVDASVNHSSGSSKTLRVKLTVSPEPSSKRKEGPPAGQDREPTRCRMEGELAEEPRVADRRLSAHVRRPSTDPQPCSERGPYCVDENTERRNHYLDLAGIENYTSRFGPGSPPVQAKQEPQGRASHLQARSRSQEPDTHAVHHRRSQVLVEHVVPASEPAARALDTQPRPKGPEKQFLKSPKGSGKPPGVPASSKSGKAFSYYLPAVLPPQAPQDGHHLPQPPPPPYGHKRYRQKGREGHSPLKAPHAQPATVEHEVVRDLPPTPAGEGYAVPVIQRHEHHHHHEHHHHHHHHHFHPS
uniprot
proteins
function
FUNCTION: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. {ECO:0000250, ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}.
uniprot
proteins
mass_dalton
50055
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Abrogates myristoylation and membrane association and impairs delivery of TGFA to the cell surface."; /evidence="ECO:0000269|PubMed:15064403
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to rapid proteasomal degradation. Interaction with TGFA interferes with RNF25 binding and protects against ubiquitination mediated by RNF25. {ECO:0000269|PubMed:18757723}.
uniprot
proteins
protein_family
NKD family
uniprot
proteins
pubmed
11356022
uniprot
proteins
pubmed
11604995
uniprot
proteins
pubmed
15064403
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17045239
uniprot
proteins
pubmed
17553928
uniprot
proteins
pubmed
18757723
uniprot
proteins
sequence_length
451
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}. Cytoplasm {ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}. Cytoplasmic vesicle {ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}.
uniprot
proteins