Surf4
entrez
20932
canonical
uniprot
Q64310
canonical
ensembl
ENSMUSG00000014867
resolver
ensp
ENSMUSP00000015011
resolver
enst
ENSMUST00000015011
resolver
genesymbol
Surf4
resolver
genesymbol_syn
Surf-4
resolver
uniprot
Q545Q2
resolver
uniprot_entry
Q545Q2_MOUSE
resolver
uniprot_entry
SURF4_MOUSE
resolver
amino_acid_sequence
MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWSCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIIQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKEW
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis. Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins (PubMed:33186557). Promotes the secretion of PCSK9. Also mediates the efficient secretion of erythropoietin (EPO). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. {ECO:0000250|UniProtKB:O15260, ECO:0000269|PubMed:33186557}.
uniprot
proteins
mass_dalton
30381
uniprot
proteins
protein_family
SURF4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21976701
uniprot
proteins
pubmed
2300057
uniprot
proteins
pubmed
31978056
uniprot
proteins
pubmed
33186557
uniprot
proteins
pubmed
7540914
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O15260}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:O15260}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O15260}; Multi-pass membrane protein {ECO:0000255}. Note=Active at endoplasmic reticulum exit sites (ERES) where it is incorporated together with its lipoprotein cargos into COPII-coated vesicles. From the Golgi it is recycled back to the endoplasmic reticulum. {ECO:0000250|UniProtKB:O15260}.
uniprot
proteins
transmembrane_region
TRANSMEM 65..85; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 242..262; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins