Sirt5
entrez
306840
canonical
uniprot
Q68FX9
canonical
ensembl
ENSRNOG00000017866
resolver
ensembl
ENSRNOG00055007740
resolver
ensembl
ENSRNOG00060009860
resolver
ensembl
ENSRNOG00065008193
resolver
ensp
ENSRNOP00000024067
resolver
ensp
ENSRNOP00055010336
resolver
ensp
ENSRNOP00060013005
resolver
ensp
ENSRNOP00065009555
resolver
enst
ENSRNOT00000024066
resolver
enst
ENSRNOT00055012952
resolver
enst
ENSRNOT00060016644
resolver
enst
ENSRNOT00065012973
resolver
genesymbol
Sirt5
resolver
uniprot_entry
SIR5_RAT
resolver
amino_acid_sequence
MRPLPVAPGRLFSQLCCGPKPSASPQSKICLTMARPSSNMADFRKCFANAKHIVIISGAGVSAESGVPTFRGTGGYWRKWQAQHLATPLAFAHNPSQVWEFYHYRREVMRNKEPNPGHLAIAQCEARLRDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCGNVAENYKSPICPALLGKGAPEPDTQESRIPVHKLPRCEEAGCGGLLRPHVVWFGENLDPAILKEVDRELARCDLCLVVGTSSVVYPAAMFAPQVASRGVPVAEFNMETTPATNRFRFHFPGPCGVTLPEALAPHETERIS
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
function
FUNCTION: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. {ECO:0000255|HAMAP-Rule:MF_03160}.
uniprot
proteins
mass_dalton
34098
uniprot
proteins
protein_family
Class III subfamily
uniprot
proteins
protein_family
Sirtuin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03160}. Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_03160}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03160}. Note=Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus. {ECO:0000255|HAMAP-Rule:MF_03160}.
uniprot
proteins