Nmur2
entrez
64042
canonical
uniprot
Q9ESQ4
canonical
ensembl
ENSRNOG00000014081
resolver
ensp
ENSRNOP00000018967
resolver
enst
ENSRNOT00000018967
resolver
genesymbol
Nmur2
resolver
genesymbol_syn
NMU2R
resolver
genesymbol_syn
Tgr1
resolver
uniprot
Q9JIB1
resolver
uniprot_entry
NMUR2_RAT
resolver
uniprot_sec
Q9JIB1
resolver
amino_acid_sequence
MGKLENASWIHDPLMKYLNSTEEYLAHLCGPKRSDLSLPVSVAYALIFLVGVMGNLLVCMVIVRHQTLKTPTNYYLFSLAVSDLLVLLLGMPLEIYEMWHNYPFLFGPVGCYFKTALFETVCFASILSVTTVSVERYVAIVHPFRAKLESTRRRALRILSLVWSFSVVFSLPNTSIHGIKFQHFPNGSSVPGSATCTVTKPMWVYNLIIQATSFLFYILPMTLISVLYYLMGLRLKRDESLEANKVAVNIHRPSRKSVTKMLFVLVLVFAICWTPFHVDRLFFSFVEEWTESLAAVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRAAFRNVVSPTCKWCHPRHRPQGPPAQKIIFLTECHLVELTEDAGPQFPGQSSIHNTNLTTAPCAGEVP
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for the neuropeptides neuromedin-U (NMU) and neuromedin-S (NMS) (PubMed:10887190, PubMed:10894543, PubMed:15635449). Functionally, is involved in regulation of feeding and energy balance (PubMed:10894543). Additionally may modulates blood pressure and smooth muscle contraction (By similarity). Mechanistically, upon ligand binding, couples to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits. GNAQ/Gaq or GNA11/Ga11 coupling leads to the activation of a phospholipase C (PLC), which hydrolyzes PIP2 (phosphatidylinositol 4,5-bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate), and subsequent intracellular calcium mobilization via IP3 receptors on the endoplasmic reticulum. GNAI1/Gai coupling inhibits forskolin-stimulated cAMP accumulation (By similarity). {ECO:0000250|UniProtKB:P12760, ECO:0000250|UniProtKB:Q9GZQ4, ECO:0000269|PubMed:10887190, ECO:0000269|PubMed:10894543, ECO:0000269|PubMed:15635449}.
uniprot
proteins
mass_dalton
44723
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10887190
uniprot
proteins
pubmed
10894543
uniprot
proteins
pubmed
15635449
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9GZQ4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9GZQ4}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..60; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9GZQ4"; TRANSMEM 75..98; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9GZQ4"; TRANSMEM 108..134; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9GZQ4"; TRANSMEM 156..176; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9GZQ4"; TRANSMEM 204..229; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9GZQ4"; TRANSMEM 260..282; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9GZQ4"; TRANSMEM 299..322; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9GZQ4
uniprot
proteins