TYW5
entrez
129450
canonical
uniprot
A2RUC4
canonical
ensembl
ENSG00000162971
resolver
ensp
ENSP00000346627
resolver
ensp
ENSP00000603577
resolver
ensp
ENSP00000767664
resolver
genesymbol
TYW5
resolver
genesymbol_syn
C2orf60
resolver
hgnc
HGNC:26754
resolver
uniprot
B2RNE3
resolver
uniprot
Q8N1R2
resolver
uniprot_entry
TYW5_HUMAN
resolver
uniprot_sec
B2RNE3
resolver
uniprot_sec
Q8N1R2
resolver
amino_acid_sequence
MAGQHLPVPRLEGVSREQFMQHLYPQRKPLVLEGIDLGPCTSKWTVDYLSQVGGKKEVKIHVAAVAQMDFISKNFVYRTLPFDQLVQRAAEEKHKEFFVSEDEKYYLRSLGEDPRKDVADIRKQFPLLKGDIKFPEFFKEEQFFSSVFRISSPGLQLWTHYDVMDNLLIQVTGKKRVVLFSPRDAQYLYLKGTKSEVLNIDNPDLAKYPLFSKARRYECSLEAGDVLFIPALWFHNVISEEFGVGVNIFWKHLPSECYDKTDTYGNKDPTAASRAAQILDRALKTLAELPEEYRDFYARRMVLHIQDKAYSKNSE
uniprot
proteins
ec_number
1.14.11.42
uniprot
proteins
function
FUNCTION: tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes. {ECO:0000269|PubMed:20739293, ECO:0000269|PubMed:20972222}.
uniprot
proteins
mass_dalton
36548
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="R->A: Abolishes enzyme activity and ability to bind tRNA."; /evidence="ECO:0000269|PubMed:20972222"; MUTAGEN 149; /note="R->A: Abolishes enzyme activity and ability to bind tRNA."; /evidence="ECO:0000269|PubMed:20972222
uniprot
proteins
pathway_participation
PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis. {ECO:0000269|PubMed:20739293, ECO:0000269|PubMed:20972222}.
uniprot
proteins
protein_family
TYW5 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
20739293
uniprot
proteins
pubmed
20972222
uniprot
proteins
sequence_length
315
uniprot
proteins