SLC25A26
entrez
115286
canonical
uniprot
Q70HW3
canonical
ensembl
ENSG00000144741
resolver
ensembl
ENSG00000282739
resolver
ensp
ENSP00000336801
resolver
ensp
ENSP00000346955
resolver
ensp
ENSP00000415304
resolver
ensp
ENSP00000487996
resolver
ensp
ENSP00000504323
resolver
ensp
ENSP00000509413
resolver
ensp
ENSP00000509933
resolver
ensp
ENSP00000510022
resolver
ensp
ENSP00000646493
resolver
ensp
ENSP00000646498
resolver
enst
ENST00000413054
resolver
enst
ENST00000633238
resolver
enst
ENST00000689520
resolver
genesymbol
SLC25A26
resolver
genesymbol_syn
SAMC
resolver
hgnc
HGNC:20661
resolver
uniprot
A0A8I5KS24
resolver
uniprot
A8K758
resolver
uniprot
B3KRZ7
resolver
uniprot
F8WAB8
resolver
uniprot
H7C430
resolver
uniprot
Q7Z786
resolver
uniprot
Q96E68
resolver
uniprot_entry
A0A8I5KS24_HUMAN
resolver
uniprot_entry
H7C430_HUMAN
resolver
uniprot_entry
SAMC_HUMAN
resolver
uniprot_sec
A8K758
resolver
uniprot_sec
B3KRZ7
resolver
uniprot_sec
F8WAB8
resolver
uniprot_sec
Q7Z786
resolver
uniprot_sec
Q96E68
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by tannic acid and Bromocresol Purple. {ECO:0000269|PubMed:14674884}.
uniprot
proteins
amino_acid_sequence
MDRPGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFSKAGGFHGIYAGVPSAAIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRAQVSASTRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRITLAKAGSSTADGNVLSVLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAYDRTHSLLLEVGRKSP
uniprot
proteins
disease_involvement
DISEASE: Combined oxidative phosphorylation deficiency 28 (COXPD28) [MIM:616794]: An autosomal recessive mitochondrial disorder characterized by decreased activities of respiratory chain enzymes, and variable clinical manifestations. Clinical features include episodic metabolic decompensation beginning in infancy, mild muscle weakness, cardiorespiratory insufficiency, developmental delay, or even death. {ECO:0000269|PubMed:26522469, ECO:0000269|PubMed:35024855}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Mitochondrial S-adenosyl-L-methionine/S-adenosyl-L-homocysteine antiporter. Mediates the exchange of cytosolic S-adenosyl-L-methionine, the predominant methyl-group donor for macromolecule methylation processes, for mitochondrial S-adenosylhomocysteine(SAH), a by-product of methylation reactions. {ECO:0000269|PubMed:14674884, ECO:0000269|PubMed:26522469, ECO:0000269|PubMed:35024855}.
uniprot
proteins
mass_dalton
29354
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
14674884
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
26522469
uniprot
proteins
pubmed
35024855
uniprot
proteins
sequence_length
274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:14674884, ECO:0000305|PubMed:26522469}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 49..69; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 85..105; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 182..202; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins