CDK6
entrez
1021
canonical
uniprot
Q00534
canonical
ensembl
ENSG00000105810
resolver
ensp
ENSP00000265734
resolver
ensp
ENSP00000397087
resolver
ensp
ENSP00000576339
resolver
ensp
ENSP00000576340
resolver
ensp
ENSP00000576341
resolver
enst
ENST00000265734
resolver
enst
ENST00000424848
resolver
enst
ENST00000906280
resolver
enst
ENST00000906281
resolver
enst
ENST00000906282
resolver
genesymbol
CDK6
resolver
genesymbol_syn
CDKN6
resolver
hgnc
HGNC:1777
resolver
uniprot
A4D1G0
resolver
uniprot_entry
CDK6_HUMAN
resolver
uniprot_sec
A4D1G0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by INK4 proteins (CDKN2C/p18-INK4c), aminopurvalanol, PD0332991, 4-(Pyrazol-4-yl)-pyrimidines and fisetin, a flavonol inhibitor. Activated by Thr-177 phosphorylation and Tyr-24 dephosphorylation (By similarity). Stimulated by cyclin from herpesvirus saimiri (V-cyclin/ECLF2). Rapidly down-regulated prior to cell differentiation (e.g. erythroid and osteoblast). {ECO:0000250, ECO:0000269|PubMed:12833137}.
uniprot
proteins
amino_acid_sequence
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
uniprot
proteins
disease_involvement
DISEASE: Microcephaly 12, primary, autosomal recessive (MCPH12) [MIM:616080]: A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. {ECO:0000269|PubMed:23918663}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.22
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}.
uniprot
proteins
mass_dalton
36938
uniprot
proteins
post_translational_modification
PTM: Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity. {ECO:0000269|PubMed:11828325}.
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11124804
uniprot
proteins
pubmed
11828325
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12833137
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14985467
uniprot
proteins
pubmed
15254224
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15689157
uniprot
proteins
pubmed
15809340
uniprot
proteins
pubmed
16096642
uniprot
proteins
pubmed
16294322
uniprot
proteins
pubmed
1639063
uniprot
proteins
pubmed
16548883
uniprot
proteins
pubmed
16789739
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17420273
uniprot
proteins
pubmed
17431401
uniprot
proteins
pubmed
19139263
uniprot
proteins
pubmed
19238148
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20333249
uniprot
proteins
pubmed
20668294
uniprot
proteins
pubmed
21038853
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23918663
uniprot
proteins
pubmed
8114739
uniprot
proteins
pubmed
9482106
uniprot
proteins
pubmed
9751050
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23918663}. Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus. Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (PubMed:23918663). {ECO:0000250|UniProtKB:Q64261, ECO:0000269|PubMed:23918663}.
uniprot
proteins