Mcpt4
entrez
17227
canonical
uniprot
P21812
canonical
ensembl
ENSMUSG00000061068
resolver
ensp
ENSMUSP00000038103
resolver
enst
ENSMUST00000043249
resolver
genesymbol
Mcpt4
resolver
uniprot
F7CY52
resolver
uniprot
Q3UN88
resolver
uniprot
Q9EPQ9
resolver
uniprot
Q9EQT2
resolver
uniprot_entry
F7CY52_MOUSE
resolver
uniprot_entry
MCPT4_MOUSE
resolver
uniprot_entry
Q3UN88_MOUSE
resolver
uniprot_sec
Q9EPQ9
resolver
uniprot_sec
Q9EQT2
resolver
activity_regulation
ACTIVITY REGULATION: Completely inhibited by serine protease inhibitors such as chymostatin, diisopropylfluorophosphate and phenylmethylsulfonyl fluoride, but not by p-tosyl-L-phenylalanine chloromethyl ketone, p-tosyl-L-lysine chloromethyl ketone, pepstatin, E-64, EDTA or o-phenanthroline. Also inhibited by lima bean trypsin inhibitor, soy bean trypsin inhibitor and human plasma alpha1-antichymotrypsin.
uniprot
proteins
amino_acid_sequence
MQALLFLMALLLPSGAGAEEIIGGVESRPHSRPYMAHLEITTERGFTATCGGFLITRQFVMTAAHCSGREITVTLGAHDVSKTESTQQKIKVEKQIVHPKYNFYSNLHDIMLLKLQKKAKETPSVNVIPLPRPSDFIKPGKMCRAAGWGRTGVTEPTSDTLREVKLRIMDKEACKNYWHYDYNLQVCVGSPRKKRSAYKGDSGGPLLCAGVAHGIVSYGRGDAKPPAVFTRISSYVPWINRVIKGE
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-|-Ile-5' bond of angiotensin I and the 'Phe-20-|-Ala-21' bond of amyloid beta-protein, and is less active towards the 'Phe-8-|-His-9' bond of angiotensin I and the 'Phe-4-|-Ala-5' and 'Tyr-10-|-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing. {ECO:0000269|PubMed:12900518, ECO:0000269|PubMed:9538257}.
uniprot
proteins
mass_dalton
27204
uniprot
proteins
protein_family
Granzyme subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
11141502
uniprot
proteins
pubmed
12900518
uniprot
proteins
pubmed
1988455
uniprot
proteins
pubmed
2060576
uniprot
proteins
pubmed
20940421
uniprot
proteins
pubmed
2326280
uniprot
proteins
pubmed
8363563
uniprot
proteins
pubmed
9538257
uniprot
proteins
sequence_length
246
uniprot
proteins