Rilpl1
entrez
75695
canonical
uniprot
Q9JJC6
canonical
ensembl
ENSMUSG00000029392
resolver
ensp
ENSMUSP00000050014
resolver
ensp
ENSMUSP00000218419
resolver
ensp
ENSMUSP00000218421
resolver
ensp
ENSMUSP00000218422
resolver
ensp
ENSMUSP00000218424
resolver
ensp
ENSMUSP00000218425
resolver
ensp
ENSMUSP00000218427
resolver
enst
ENSMUST00000062153
resolver
genesymbol
Rilpl1
resolver
uniprot
Q80WV8
resolver
uniprot_entry
RIPL1_MOUSE
resolver
uniprot_sec
Q80WV8
resolver
amino_acid_sequence
MEEPLGSPPAALSALEKNVAELTVMDVYDIASLVGHEFERVIDQHGCESIARLMPKVVRVLEILEVLVSRHHVAPELDELRLELDRLRVERMDRIEKERKHQKELELVEDVWRGEAQDLLSQIAQLQEENKQLMTNLNHKDVGFSEEEFQKQEGMSERERQVMKRLKEVVDKQRDELRAKDRELGLKNEDVEALQQQQTRLMKINHDLRHRVTVVEAQGKALIEQKVELEADLQTKEQEMGSLRAELGKLRERLQGEHSQNGEEEEAEIQPQPDGEESISDAEKAALDLKDPNRPRFTLQELRDVLHERNELKSKVFLLQEELAYYKSEEIEEENRIPQPPPITHPRTSPQPESGIKRLFSFFSRDKKRLANTQRPTHIHESFGQWAITQRDDGYTEQGQEALQHL
uniprot
proteins
function
FUNCTION: Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution (By similarity). Plays a role in the regulation of cell shape and polarity (PubMed:23264467). Plays a role in cellular protein transport, including protein transport away from primary cilia (PubMed:23264467). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (By similarity). {ECO:0000250|UniProtKB:D3ZUQ0, ECO:0000250|UniProtKB:Q5EBL4, ECO:0000269|PubMed:23264467}.
uniprot
proteins
mass_dalton
47323
uniprot
proteins
post_translational_modification
PTM: S-nitrosylation is required for the interaction with GAPDH. {ECO:0000250}.
uniprot
proteins
protein_family
RILPL family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23264467
uniprot
proteins
pubmed
29125462
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5EBL4}. Cell projection, cilium {ECO:0000269|PubMed:23264467}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23264467}.
uniprot
proteins