OLIG1
entrez
116448
canonical
uniprot
Q8TAK6
canonical
ensembl
ENSG00000184221
resolver
ensp
ENSP00000371785
resolver
enst
ENST00000382348
resolver
genesymbol
OLIG1
resolver
genesymbol_syn
BHLHB6
resolver
genesymbol_syn
BHLHE21
resolver
hgnc
HGNC:16983
resolver
uniprot
Q7RTS0
resolver
uniprot_entry
OLIG1_HUMAN
resolver
uniprot_sec
Q7RTS0
resolver
amino_acid_sequence
MYYAVSQARVNAVPGTMLRPQRPGDLQLGASLYELVGYRQPPSSSSSSTSSTSSTSSSSTTAPLLPKAAREKPEAPAEPPGPGPGSGAHPGGSARPDAKEEQQQQLRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLGSSLQELRRALGEGAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPDALRPAKYLSLALDEPPCGQFALPGGGAGGPGLCTCAVCKFPHLVPASLGLAAVQAQFSK
uniprot
proteins
function
FUNCTION: Orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis. In cooperation with OLIG2, activates oligodendrocyte precursor cells (OPCs) formation while repressing the generation of olfactory bulb interneuron intermediate progenitors (OBIN) through transcriptional regulation of GSX2. Mechanistically, binds and silences multiple conserved enhancer elements of GSX2. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity). {ECO:0000250|UniProtKB:Q9JKN5, ECO:0000269|PubMed:10719889}.
uniprot
proteins
mass_dalton
27905
uniprot
proteins
post_translational_modification
PTM: 'Lys-63'-linked polyubiquitinated by RNF220; leading to stabilization during oligodendroglial development and myelination. {ECO:0000269|PubMed:38324685}.
uniprot
proteins
pubmed
10719889
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
11526205
uniprot
proteins
pubmed
14516699
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
38324685
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
uniprot
proteins