Rab13
entrez
81756
canonical
uniprot
P35286
canonical
ensembl
ENSRNOG00000016733
resolver
ensp
ENSRNOP00000022626
resolver
ensp
ENSRNOP00000071741
resolver
enst
ENSRNOT00000092112
resolver
genesymbol
Rab13
resolver
uniprot
A0A8L2UQH0
resolver
uniprot
Q8K3X5
resolver
uniprot_entry
A0A8L2UQH0_RAT
resolver
uniprot_entry
RAB13_RAT
resolver
uniprot_sec
Q8K3X5
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including DENND1C, which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) (By similarity). Activated in response to insulin (PubMed:21041651). {ECO:0000250|UniProtKB:P51153, ECO:0000269|PubMed:21041651}.
uniprot
proteins
amino_acid_sequence
MAKAYDHLFKLLLIGDSGVGKTCLIIRFAEDNFNSTYISTIGIDFKIRTVEIEGKRIKLQVWDTAGQERFKTITTAYYRGAMGIILVYDITDEKSFENIQNWMKSIKENASAGVERLLLGNKCDMEAKRKVQREQAERLAREHRIRFFETSAKSSVNVDEAFSSLARDILLKTGGRRSGNSSKPSSTDLKVSDKKNSNKCSLG
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB13 is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. {ECO:0000269|PubMed:20008558, ECO:0000269|PubMed:21041651, ECO:0000269|PubMed:23419316}.
uniprot
proteins
mass_dalton
22901
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated via 'Lys-11'-linked ubiquitination on Lys-46 and Lys-58; impairing the recruitment of guanosine diphosphate (GDP) dissociation inhibitor 1/GDI1. {ECO:0000250|UniProtKB:P51153}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
1313420
uniprot
proteins
pubmed
19074001
uniprot
proteins
pubmed
20008558
uniprot
proteins
pubmed
21041651
uniprot
proteins
pubmed
22562557
uniprot
proteins
pubmed
23419316
uniprot
proteins
pubmed
23772379
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P51153}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P51153}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell junction, tight junction {ECO:0000250|UniProtKB:P51153}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P51153}. Recycling endosome membrane {ECO:0000250|UniProtKB:P51153}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9DD03}. Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions (By similarity). Relocalizes to the leading edge of lamellipodia in migrating endothelial cells (By similarity). {ECO:0000250|UniProtKB:P51153, ECO:0000250|UniProtKB:Q9DD03}.
uniprot
proteins