Hsd17b2
entrez
79243
canonical
uniprot
Q62730
canonical
ensembl
ENSRNOG00000013982
resolver
ensembl
ENSRNOG00055021964
resolver
ensembl
ENSRNOG00060023663
resolver
ensembl
ENSRNOG00065006369
resolver
ensp
ENSRNOP00000018795
resolver
ensp
ENSRNOP00055030724
resolver
ensp
ENSRNOP00060033910
resolver
ensp
ENSRNOP00065007084
resolver
enst
ENSRNOT00000018795
resolver
enst
ENSRNOT00055037681
resolver
enst
ENSRNOT00060040976
resolver
enst
ENSRNOT00065009780
resolver
genesymbol
Hsd17b2
resolver
genesymbol_syn
Edh17b2
resolver
uniprot
F7EZ71
resolver
uniprot
Q5I0N4
resolver
uniprot_entry
DHB2_RAT
resolver
uniprot_entry
F7EZ71_RAT
resolver
uniprot_entry
Q5I0N4_RAT
resolver
amino_acid_sequence
MNPFSSESAWLCLTATAVLGGMLLCKAWSSGQLRSQVVCLAGLWGGACLLSLSLLCSLFLLSVSCFFLLYVSSSDQDLLPVDQKAVLVTGADSGFGHALAKHLDKLGFTVFAGVLDKEGPGAEELRKNCSERLSVLQMDVTKPEQIKDVHSEVAEKIQDKGLWAVVNNAGVLHFPIDGELIPMTVYRKCMAVNFFGAVEVTKVFLPLLRKSKGRLVNVSSMGAMIPFQMVAAYASTKAAISMFSAVIRQELAKWGVKVVTIHPGGFQTNIVGSQDSWDKMEKEILDHFSKEIQENYGQEYVHTQKLALPVMREMSNPDITPVLRDIQHAICAKNPSSFYCSGRMTYLWICFAAYSPISLLDYILKNYFTPKLMPRALRTAS
uniprot
proteins
ec_number
1.1.1.239
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
function
FUNCTION: Catalyzes the NAD-dependent oxidation of highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione (PubMed:8612487). Also has 20-alpha-HSD activity (By similarity). {ECO:0000250|UniProtKB:P37059, ECO:0000269|PubMed:8612487}.
uniprot
proteins
mass_dalton
41967
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
8612487
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P37059}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P37059}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins