Prxl2a
entrez
70564
canonical
uniprot
Q9CYH2
canonical
ensembl
ENSMUSG00000021792
resolver
ensp
ENSMUSP00000022317
resolver
ensp
ENSMUSP00000112377
resolver
ensp
ENSMUSP00000117278
resolver
ensp
ENSMUSP00000122866
resolver
ensp
ENSMUSP00000172627
resolver
ensp
ENSMUSP00000172631
resolver
ensp
ENSMUSP00000172632
resolver
enst
ENSMUST00000022317
resolver
enst
ENSMUST00000118466
resolver
enst
ENSMUST00000153830
resolver
genesymbol
Prxl2a
resolver
genesymbol_syn
5730469M10Rik
resolver
genesymbol_syn
Fam213a
resolver
genesymbol_syn
Pamm
resolver
uniprot
F6TB85
resolver
uniprot
Q3U125
resolver
uniprot_entry
F6TB85_MOUSE
resolver
uniprot_entry
PXL2A_MOUSE
resolver
uniprot_entry
Q3U125_MOUSE
resolver
amino_acid_sequence
MGMWSIGVGAVGAAAVALLLANTDMFLSKPRKAALEYLEDIDLKTLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCRAEAADLMSLKPKLDELGVPLYAVVKEQVKREVEDFQPYFKGEIFLDEKKKFYGPERRKMMFMGLIRLGVWYNSFRAWNGGFSGNLEGEGFILGGVFVIGSGKQGILLEHREKEFGDRVNPLSVLEAVKKIKLQTPASGRS
uniprot
proteins
function
FUNCTION: Involved in redox regulation of the cell (By similarity). Acts as an antioxidant (By similarity). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (By similarity). May affect bone resorption and help to maintain bone mass (By similarity). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880). {ECO:0000250|UniProtKB:Q9BRX8, ECO:0000269|PubMed:26438880}.
uniprot
proteins
mass_dalton
24395
uniprot
proteins
protein_family
PRXL2A subfamily
uniprot
proteins
protein_family
Peroxiredoxin-like PRXL2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19951071
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26438880
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BRX8}. Secreted {ECO:0000269|PubMed:26438880}. Note=Secreted from mature adipocytes but not from preadipocytes. {ECO:0000250|UniProtKB:Q9BRX8}.
uniprot
proteins