Avil
entrez
11567
canonical
uniprot
O88398
canonical
ensembl
ENSMUSG00000025432
resolver
ensp
ENSMUSP00000026500
resolver
ensp
ENSMUSP00000123405
resolver
enst
ENSMUST00000026500
resolver
enst
ENSMUST00000129173
resolver
genesymbol
Avil
resolver
genesymbol_syn
Advil
resolver
uniprot
O70466
resolver
uniprot
Q3TBC5
resolver
uniprot
Q3U1K5
resolver
uniprot_entry
AVIL_MOUSE
resolver
uniprot_entry
Q3TBC5_MOUSE
resolver
uniprot_sec
O70466
resolver
uniprot_sec
Q3U1K5
resolver
amino_acid_sequence
MSLSSAFRAVSNDPRIITWRIEKMELALVPLSAHGNFYEGDCYIVLSTRRVGSLLSQNIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKKGGVASGMKHVETNTYDVKRLLHVKGKRNIQATEVEMSWDSFNRGDVFLLDLGMVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAEIGVIEGDKEAASPGLMTVLQDTLGRRSMIKPAVSDEIMDQQQKSSIMLYHVSDTAGQLSVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKVEKQAAMSKALDFIKMKGYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTTGLGKIFSTGKIAKIFQDKFDVSLLHTKPEVAAQERMVDDGKGQVEVWRIENLELVPVEYQWHGFFYGGDCYLVLYTYDVNGKPHYILYIWQGRHASRDELAASAYRAVEVDQQFDGAPVQVRVSMGKEPRHFMAIFKGKLVIYEGGTSRKGNEEPDPPVRLFQIHGNDKSNTKAVEVSASASSLNSNDVFLLRTQAEHYLWYGKGSSGDERAMAKELVDLLCDGNADTVAEGQEPPEFWDLLGGKTAYANDKRLQQETLDVQVRLFECSNKTGRFLVTEVTDFTQEDLSPGDVMLLDTWDQVFLWIGAEANATEKKGALSTAQEYLVTHPSGRDPDTPILIIKQGFEPPTFTGWFLAWDPHIWSEGKSYEQLKNELGDATAIVRITADMKNATLYLNPSDGEPKYYPVEVLLKGQNQELPEDVDPAKKENYLSEQDFVSVFGITRGQFTALPGWKQLQLKKERGLF
uniprot
proteins
function
FUNCTION: Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis (PubMed:15247299, PubMed:18160648). In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (By similarity). {ECO:0000250|UniProtKB:O75366, ECO:0000269|PubMed:15247299, ECO:0000269|PubMed:18160648}.
uniprot
proteins
mass_dalton
92032
uniprot
proteins
protein_family
Villin/gelsolin family
uniprot
proteins
pubmed
15247299
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
18160648
uniprot
proteins
pubmed
9649432
uniprot
proteins
pubmed
9664034
uniprot
proteins
sequence_length
819
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O75366}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O75366}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:O75366}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q9WU06}. Cell projection, axon {ECO:0000250|UniProtKB:Q9WU06}. Note=In podocytes, present in the F-actin-enriched cell periphery that generates lamellipodia and focal adhesions. {ECO:0000250|UniProtKB:O75366}.
uniprot
proteins