Bcl2l10
entrez
114552
canonical
uniprot
Q99M66
canonical
ensembl
ENSRNOG00000009308
resolver
ensembl
ENSRNOG00055007298
resolver
ensembl
ENSRNOG00060016485
resolver
ensembl
ENSRNOG00065016865
resolver
ensp
ENSRNOP00000012409
resolver
ensp
ENSRNOP00055009654
resolver
ensp
ENSRNOP00060022755
resolver
ensp
ENSRNOP00065022273
resolver
enst
ENSRNOT00000012409
resolver
enst
ENSRNOT00055012156
resolver
enst
ENSRNOT00060028243
resolver
enst
ENSRNOT00065028160
resolver
genesymbol
Bcl2l10
resolver
genesymbol_syn
Bcl-b
resolver
genesymbol_syn
Boo
resolver
genesymbol_syn
Diva
resolver
uniprot_entry
B2L10_RAT
resolver
amino_acid_sequence
MGDPLQDRTRRLLTDYILFCARAPNTPEPLPTSVEAALLRSVTSQIQQEHQDLFNSFRDYQGNRLELVTQMADELLSNDQEFNWGRLVMLLAFVGTLMNQDRTVKRRRDQRNRLLLERDCYLIVSLLYNRLTGRHRSWLEAHGGWDGFCQFFKNPLPPGFWRRLLIRAILSCFFATAIFYIWKCL
uniprot
proteins
function
FUNCTION: Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (By similarity). Increases binding of AHCYL1/IRBIT to ITPR1 (By similarity). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (By similarity). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (By similarity). Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2 (By similarity). {ECO:0000250|UniProtKB:Q9HD36, ECO:0000250|UniProtKB:Q9Z0F3}.
uniprot
proteins
mass_dalton
21859
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated by UBQLN1; results in stabilization of BCL2L10 protein abundance and in relocalization from mitochondria to cytoplasm. {ECO:0000250|UniProtKB:Q9HD36}.
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
12787069
uniprot
proteins
pubmed
17532299
uniprot
proteins
sequence_length
185
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9HD36}. Nucleus membrane {ECO:0000250|UniProtKB:Q9HD36}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9HD36}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9Z0F3}. Note=Localizes to mitochondria-associated endoplasmic reticulum membranes (MAMs) (By similarity). Localization to MAMs is greatly reduced under apoptotic stress conditions (By similarity). {ECO:0000250|UniProtKB:Q9HD36}.
uniprot
proteins
transmembrane_region
TRANSMEM 160..182; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins