FCMR
entrez
9214
canonical
uniprot
O60667
canonical
ensembl
ENSG00000162894
resolver
ensp
ENSP00000356058
resolver
ensp
ENSP00000404136
resolver
ensp
ENSP00000485739
resolver
ensp
ENSP00000580366
resolver
ensp
ENSP00000634795
resolver
ensp
ENSP00000677793
resolver
ensp
ENSP00000677794
resolver
genesymbol
FCMR
resolver
genesymbol_syn
FAIM3
resolver
genesymbol_syn
TOSO
resolver
hgnc
HGNC:14315
resolver
uniprot
A8K7J2
resolver
uniprot
B7Z6Z0
resolver
uniprot
D9MWM3
resolver
uniprot_entry
FCMR_HUMAN
resolver
uniprot_sec
A8K7J2
resolver
uniprot_sec
B7Z6Z0
resolver
uniprot_sec
D9MWM3
resolver
amino_acid_sequence
MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLPEMHVRIYLCREMAGSGTCGTVVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVYACGAGMNTDRGKTQKVTLNVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFVTRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALDYGSQSGREGQGFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQRPRGSPRPRSQNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVSESPWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINVPA
uniprot
proteins
function
FUNCTION: High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM (PubMed:19858324, PubMed:22675200, PubMed:36949194, PubMed:37095205). Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane-bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues (PubMed:21908732, PubMed:28230186). Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF-kappa-B, MAP kinases and calcium signaling pathways (PubMed:19858324, PubMed:22675200, PubMed:25601920, PubMed:30840890). {ECO:0000269|PubMed:19858324, ECO:0000269|PubMed:21908732, ECO:0000269|PubMed:22675200, ECO:0000269|PubMed:25601920, ECO:0000269|PubMed:28230186, ECO:0000269|PubMed:30840890, ECO:0000269|PubMed:36949194, ECO:0000269|PubMed:37095205}.
uniprot
proteins
mass_dalton
43146
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="R->A: Completely abolishes interaction with IgM resulting in impaired IgM internalization."; /evidence="ECO:0000269|PubMed:36949194"; MUTAGEN 67; /note="F->A: Completely abolishes interaction with IgM; when associated with A-69."; /evidence="ECO:0000269|PubMed:36949194"; MUTAGEN 69; /note="K->A: Completely abolishes interaction with IgM; when associated with A-67."; /evidence="ECO:0000269|PubMed:36949194"; MUTAGEN 109; /note="N->A: Displays reduced interaction with IgM; when associated with A-112."; /evidence="ECO:0000269|PubMed:36949194"; MUTAGEN 112; /note="R->A: Displays reduced interaction with IgM; when associated with A-109."; /evidence="ECO:0000269|PubMed:36949194"; MUTAGEN 164; /note="T->A: Impairs O-glycosylation and trafficking to the plasma membrane; when associated with A-165."; /evidence="ECO:0000269|PubMed:21908732"; MUTAGEN 165; /note="T->A: Impairs O-glycosylation and trafficking to the plasma membrane; when associated with A-164."; /evidence="ECO:0000269|PubMed:21908732"; MUTAGEN 178; /note="S->A: Impairs O-glycosylation and trafficking to the plasma membrane; when associated with A-179, A-181, A-182 and A-185."; /evidence="ECO:0000269|PubMed:21908732"; MUTAGEN 179; /note="S->A: Impairs O-glycosylation and trafficking to the plasma membrane; when associated with A-178, A-181, A-182 and A-185."; /evidence="ECO:0000269|PubMed:21908732"; MUTAGEN 181; /note="T->A: Impairs O-glycosylation and trafficking to the plasma membrane; when associated with A-178, A-179, A-182 and A-185."; /evidence="ECO:0000269|PubMed:21908732"; MUTAGEN 182; /note="T->A: Impairs O-glycosylation and trafficking to the plasma membrane; when associated with A-178, A-179, A-181 and A-185."; /evidence="ECO:0000269|PubMed:21908732"; MUTAGEN 185; /note="T->A: Impairs O-glycosylation and trafficking to the plasma membrane; when associated with A-178, A-179, A-181 and A-182."; /evidence="ECO:0000269|PubMed:21908732"; MUTAGEN 203; /note="T->A: Does not affect O-glycosylation or trafficking to the plasma membrane."; /evidence="ECO:0000269|PubMed:21908732"; MUTAGEN 253; /note="H->F: Enhances receptor capping."; /evidence="ECO:0000269|PubMed:25601920"; MUTAGEN 273..323; /note="Missing: Has no effect on IgM binding or trafficking."; /evidence="ECO:0000269|PubMed:21908732"; MUTAGEN 315; /note="Y->F: Does not affect receptor-mediated endocytosis. Abolishes calcium mobilization upon co-ligation of FCMR and CD2."; /evidence="ECO:0000269|PubMed:25601920"; MUTAGEN 324..357; /note="Missing: Abolishes trafficking to the plasma membrane."; /evidence="ECO:0000269|PubMed:21908732"; MUTAGEN 359..390; /note="Missing: Does not affect expression or IgM binding at the cell surface. Abolishes internalization via endocytosis."; /evidence="ECO:0000269|PubMed:21908732"; MUTAGEN 366; /note="Y->F: Abolishes receptor-mediated endocytosis and calcium mobilization upon co-ligation of FCMR and CD2."; /evidence="ECO:0000269|PubMed:25601920"; MUTAGEN 385; /note="Y->F: Abolishes receptor-mediated endocytosis and calcium mobilization upon co-ligation of FCMR and CD2."; /evidence="ECO:0000269|PubMed:25601920
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on both Tyr and Ser residues. {ECO:0000269|PubMed:19858324}.; PTM: O-glycosylated. Sialylated. O-linked glycans regulate trafficking to the plasma membrane. {ECO:0000269|PubMed:19858324, ECO:0000269|PubMed:21908732}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19858324
uniprot
proteins
pubmed
21908424
uniprot
proteins
pubmed
21908732
uniprot
proteins
pubmed
22675200
uniprot
proteins
pubmed
25601920
uniprot
proteins
pubmed
25888699
uniprot
proteins
pubmed
28230186
uniprot
proteins
pubmed
30840890
uniprot
proteins
pubmed
36949194
uniprot
proteins
pubmed
37095205
uniprot
proteins
pubmed
9586636
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19858324, ECO:0000269|PubMed:21908424, ECO:0000269|PubMed:22675200, ECO:0000269|PubMed:30840890}; Single-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:21908732}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21908732}; Single-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:21908732}; Single-pass membrane protein {ECO:0000255}. Note=Continuously recycles between cytoplasmic pool and the plasma membrane to bind as much IgM as possible. {ECO:0000269|PubMed:30840890}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:21908424}. Note=Detected in the serum. {ECO:0000269|PubMed:21908424}.
uniprot
proteins
transmembrane_region
TRANSMEM 252..272; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins