IGF2
entrez
3481
canonical
uniprot
P01344
canonical
ensembl
ENSG00000167244
resolver
ensp
ENSP00000370796
resolver
ensp
ENSP00000391826
resolver
ensp
ENSP00000402047
resolver
ensp
ENSP00000414497
resolver
ensp
ENSP00000511997
resolver
genesymbol
IGF2
resolver
genesymbol_syn
IGF-2
resolver
hgnc
HGNC:5466
resolver
uniprot
B3KX48
resolver
uniprot
B7WP08
resolver
uniprot
C9JAF2
resolver
uniprot
E3UN45
resolver
uniprot
E3UN46
resolver
uniprot
P78449
resolver
uniprot
Q14299
resolver
uniprot
Q1WM26
resolver
uniprot
Q9UC68
resolver
uniprot
Q9UC69
resolver
uniprot_entry
E3UN46_HUMAN
resolver
uniprot_entry
IGF2_HUMAN
resolver
uniprot_sec
B3KX48
resolver
uniprot_sec
B7WP08
resolver
uniprot_sec
C9JAF2
resolver
uniprot_sec
E3UN45
resolver
uniprot_sec
P78449
resolver
uniprot_sec
Q14299
resolver
uniprot_sec
Q1WM26
resolver
uniprot_sec
Q9UC68
resolver
uniprot_sec
Q9UC69
resolver
amino_acid_sequence
MGIPMGKSMLVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRVSRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTPPTVLPDNFPRYPVGKFFQYDTWKQSTQRLRRGLPALLRARRGHVLAKELEAFREAKRHRPLIALPTQDPAHGGAPPEMASNRK
uniprot
proteins
disease_involvement
DISEASE: Silver-Russell syndrome 1 (SRS1) [MIM:180860]: A form of Silver-Russell syndrome, a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age. SRS1 is caused by epigenetic changes of DNA hypomethylation at the telomeric imprinting control region (ICR1) on chromosome 11p15, involving the H19 and IGF2 genes. {ECO:0000269|PubMed:19066168}. Note=The gene represented in this entry is involved in disease pathogenesis.; DISEASE: Silver-Russell syndrome 3 (SRS3) [MIM:616489]: A form of Silver-Russell syndrome, a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age. SRS3 inheritance is autosomal dominant. {ECO:0000269|PubMed:26154720, ECO:0000269|PubMed:28796236}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity). {ECO:0000250|UniProtKB:P09535, ECO:0000269|PubMed:28873464, ECO:0000305|PubMed:24593700}.; FUNCTION: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. {ECO:0000269|PubMed:16912056}.
uniprot
proteins
mass_dalton
20140
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="R->E: Does not affect integrin binding. Defective integrin binding and IGF2 signaling; when associated with E-58; E-61 and E-62."; /evidence="ECO:0000269|PubMed:28873464"; MUTAGEN 58; /note="R->E: Does not affect integrin binding. Defective integrin binding and IGF2 signaling; when associated with E-48; E-61 and E-62."; /evidence="ECO:0000269|PubMed:28873464"; MUTAGEN 61; /note="R->E: Does not affect integrin binding. Defective integrin binding and IGF2 signaling; when associated with E-48; E-58 and E-62."; /evidence="ECO:0000269|PubMed:28873464"; MUTAGEN 62; /note="R->E: Does not affect integrin binding. Defective integrin binding and IGF2 signaling; when associated with E-48; E-58 and E-61."; /evidence="ECO:0000269|PubMed:28873464"; MUTAGEN 64; /note="R->E: Slight but significant increase in integrin binding."; /evidence="ECO:0000269|PubMed:28873464"; MUTAGEN 92; /note="R->A: Decreases mature IGF2 levels."; /evidence="ECO:0000269|PubMed:16040806"; MUTAGEN 112; /note="K->A: No effect in proteolytical processing."; /evidence="ECO:0000269|PubMed:16040806"; MUTAGEN 128; /note="R->A: Abolishes proteolytical processing."; /evidence="ECO:0000269|PubMed:16040806
uniprot
proteins
post_translational_modification
PTM: O-glycosylated with core 1 or possibly core 8 glycans. Thr-96 is a minor glycosylation site compared to Thr-99. {ECO:0000269|PubMed:1569071, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:23234360}.; PTM: Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2. {ECO:0000269|PubMed:16040806}.
uniprot
proteins
protein_family
Insulin family
uniprot
proteins
pubmed
11448941
uniprot
proteins
pubmed
12586351
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15359740
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
1569071
uniprot
proteins
pubmed
16040806
uniprot
proteins
pubmed
16531418
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16912056
uniprot
proteins
pubmed
18046459
uniprot
proteins
pubmed
18563800
uniprot
proteins
pubmed
19066168
uniprot
proteins
pubmed
19838169
uniprot
proteins
pubmed
20842449
uniprot
proteins
pubmed
22171320
uniprot
proteins
pubmed
23234360
uniprot
proteins
pubmed
2450353
uniprot
proteins
pubmed
24593700
uniprot
proteins
pubmed
26154720
uniprot
proteins
pubmed
2722836
uniprot
proteins
pubmed
28796236
uniprot
proteins
pubmed
28873464
uniprot
proteins
pubmed
3002851
uniprot
proteins
pubmed
3167054
uniprot
proteins
pubmed
3476948
uniprot
proteins
pubmed
3652904
uniprot
proteins
pubmed
3653397
uniprot
proteins
pubmed
3683205
uniprot
proteins
pubmed
3881277
uniprot
proteins
pubmed
6189745
uniprot
proteins
pubmed
6382021
uniprot
proteins
pubmed
6382022
uniprot
proteins
pubmed
658418
uniprot
proteins
pubmed
7527339
uniprot
proteins
pubmed
7633596
uniprot
proteins
pubmed
7730145
uniprot
proteins
sequence_length
180
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16040806}.
uniprot
proteins