Mcm6
entrez
17219
canonical
uniprot
P97311
canonical
ensembl
ENSMUSG00000026355
resolver
ensp
ENSMUSP00000027601
resolver
ensp
ENSMUSP00000140308
resolver
enst
ENSMUST00000027601
resolver
enst
ENSMUST00000190495
resolver
genesymbol
Mcm6
resolver
genesymbol_syn
Mcmd6
resolver
genesymbol_syn
Mis5
resolver
uniprot
A0A087WQR1
resolver
uniprot
Q3ULG5
resolver
uniprot
Q542I2
resolver
uniprot
Q80YQ7
resolver
uniprot
Q8C5L1
resolver
uniprot_entry
A0A087WQR1_MOUSE
resolver
uniprot_entry
MCM6_MOUSE
resolver
uniprot_entry
Q3ULG5_MOUSE
resolver
uniprot_entry
Q542I2_MOUSE
resolver
uniprot_entry
Q8C5L1_MOUSE
resolver
uniprot_sec
Q80YQ7
resolver
amino_acid_sequence
MDLAAAAEPGAGSQHPEVRDEVAEKCQKLFLDFLEEFQGSDGEIKYLQFAEELIRPERNTLVVSFADLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPFAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIKDVEQQFKYTQPNICRNPVCANRKRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDRCDFTGALIVVPDVSKLSTPGARAETNSRVSGADGYETEGIRGLRALGVRDLSYRLVFLACHVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKRLRQRDGSGVTKSSWRITVRQLESMIRLSESMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMETDEGQGGVNGHADSPAPVNRFNGSSEDASQETVSKPSLRLGFAEYCRISNLIVLHLRKMEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKTIIEKVVHRLTHYDHVLIELTQAGLKGSSEGSESYEEDPYLVVNPNYLLED
uniprot
proteins
ec_number
3.6.4.12
uniprot
proteins
function
FUNCTION: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. {ECO:0000269|PubMed:10567526}.
uniprot
proteins
mass_dalton
92867
uniprot
proteins
mutagenesis
MUTAGEN 402..403; /note="KS->AA: Decreased MCM complex DNA helicase activity. Loss of ATP-binding. Decreased MCM complex ATPase activity. No effect on MCM complex formation."; /evidence="ECO:0000269|PubMed:10567526"; MUTAGEN 460..461; /note="DE->AA: Loss of MCM complex DNA helicase activity. Loss of ATP-binding. No effect on MCM complex formation. No effect on MCM complex ATPase activity and ssDNA binding."; /evidence="ECO:0000269|PubMed:10567526
uniprot
proteins
post_translational_modification
PTM: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. {ECO:0000250|UniProtKB:Q14566}.
uniprot
proteins
protein_family
MCM family
uniprot
proteins
pubmed
10567526
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
9077461
uniprot
proteins
sequence_length
821
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q14566}. Chromosome {ECO:0000250|UniProtKB:Q14566}. Note=Binds to chromatin during G1 and detaches from it during S phase. {ECO:0000250|UniProtKB:Q14566}.
uniprot
proteins