Trpc4ap
entrez
56407
canonical
uniprot
Q9JLV2
canonical
ensembl
ENSMUSG00000038324
resolver
ensp
ENSMUSP00000037574
resolver
ensp
ENSMUSP00000099429
resolver
genesymbol
Trpc4ap
resolver
genesymbol_syn
Trrp4ap
resolver
uniprot
Q3TB80
resolver
uniprot
Q3TDP6
resolver
uniprot
Q920J6
resolver
uniprot
Q99L03
resolver
uniprot_entry
Q3TB80_MOUSE
resolver
uniprot_entry
Q3TDP6_MOUSE
resolver
uniprot_entry
TP4AP_MOUSE
resolver
uniprot_sec
Q920J6
resolver
uniprot_sec
Q99L03
resolver
amino_acid_sequence
MAAAPAAAGAGASRGRRLAATAAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKLSKWSGIPQLLLKLYATSHLHSDFVECQSILKEISPLLSMEAMAFVTEDRKFTQEATYPNTYIFDLFGGVDLLVEILMRPTISIRGQKLKISDEMSKDCLSILYNTCVCTEGVTKRLAEKNDFVIFLFTLMTSKKTFLQTATLIEDILGVKKEMIRLDEVPNLSSLVSNFDQQQLANFCRILAVTISEMDTGNDDKHTLLAKNAQQKKSLSLGPSAAEINQAALLSIPGFVERLCKLATRKVSESTGTASFLQELEEWYTWLDNALVLDALMRVANEESEHNQAPTVFPSLGTSEEGGLPHTSARAQLPQSMKIMHEIMYKLEVLYVLCVLLMGRQRNQVHRMIAEFKLIPGLNNLFDKLIWRKHSASALVLHGHNQNCDCSPDITLKIQFLRLLQSFSDHHENKYLLLNNQELNELSAISLKANIPEVEAVLNTDRSLVCDGKRGLLTRLLQVMKKEPAESSFRFWQARAVESFLRGTTSYADQMFLLKRGLLEHILYCIVDSECKSRDVLQSYFDLLGELMKFNVDAFKRFNKYINTDAKFQVFLKQINSSLVDSNMLVRCVTLSLDRFENQVDMKVAEVLSECRLLAYISQVPTQMSFLFRLINIIHVQTLTQENVSCLNTSLVILMLARRKERLPLYLRLLQRMEHSKKYPGFLLNNFHNLLRFWQQHYLHKDKDSTCLENSSCISFSYWKETVSILLNPDRQSPSALVSYIEEPYMDIDRDFTEE
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway. The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation (By similarity). Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome (PubMed:14585990). Involved in JNK activation via its interaction with TRAF2 (PubMed:16876162). Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1 (PubMed:20458742). {ECO:0000250|UniProtKB:Q8TEL6, ECO:0000269|PubMed:14585990, ECO:0000269|PubMed:16876162, ECO:0000269|PubMed:20458742}.
uniprot
proteins
mass_dalton
90727
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8TEL6}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3B; phosphorylation is required for ubiquitination. {ECO:0000250|UniProtKB:Q8TEL6}.; PTM: Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase containing SKP2, leading to its degradation. Phosphorylation by GSK3B is required for ubiquitination. {ECO:0000250|UniProtKB:Q8TEL6}.
uniprot
proteins
pubmed
14585990
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16876162
uniprot
proteins
pubmed
20458742
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
797
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8TEL6}.
uniprot
proteins