Fignl1
entrez
60530
canonical
uniprot
Q8BPY9
canonical
ensembl
ENSMUSG00000035455
resolver
ensp
ENSMUSP00000036932
resolver
ensp
ENSMUSP00000105290
resolver
ensp
ENSMUSP00000126340
resolver
ensp
ENSMUSP00000127489
resolver
ensp
ENSMUSP00000288988
resolver
ensp
ENSMUSP00000288989
resolver
enst
ENSMUST00000047689
resolver
enst
ENSMUST00000109664
resolver
enst
ENSMUST00000171080
resolver
enst
ENSMUST00000171938
resolver
genesymbol
Fignl1
resolver
uniprot
Q3UF48
resolver
uniprot
Q8C2I6
resolver
uniprot
Q9ERZ5
resolver
uniprot_entry
FIGL1_MOUSE
resolver
uniprot_sec
Q3UF48
resolver
uniprot_sec
Q8C2I6
resolver
uniprot_sec
Q9ERZ5
resolver
activity_regulation
ACTIVITY REGULATION: Ability to mediate disassembly of RAD51 filaments is inhibited by SWSAP1. Ability to mediate disassembly of RAD51 filaments is inhibited by BRCA2. {ECO:0000250|UniProtKB:Q6PIW4}.
uniprot
proteins
amino_acid_sequence
METSSSMSVETTRSVQVDEWQKNYCVVTSSICTPKQKADAYRALLLHIQYAYANSEISQVFATNLFKRYTEKYSAIIDSDNVVTGLNNYAESIFALAGSRQADSNKWQSGLSIDNVFKMSCVQEMMQAGKKFEESLLEPADASVVLCKEPTAFEVPQLSVCGGSEDADILSSSGHDTDKTQAIPGSSLRCSPFQSARLPKETNTTKTCLTSSTSLGESATAAFHMTPLFGNTEKDTQSFPKTSTGLNMFLSNLSCVPSGCENPQERKAFNDSDIIDILSNPTLNKAPSKTEDRGRREDNSLPTFKTAKEQLWVDQKKKGHQSQHTSKSSNGVMKKSLGAGRSRGIFGKFVPPVSNKQDGSEQHAKKHKSSRAGSAEPAHLTDDCLKNVEPRMVELIMNEIMDHGPPVHWDDIAGVEFAKATIKEIVVWPMMRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIVGNLMSKEQCCLSDEETDLVVQQSDGFSGADMTQLCREASLGPIRSLHAADIATISPDQVRPIAYIDFENAFKTVRPTVSPKDLELYENWNETFGCGK
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: ATPase that maintains genome stability by acting as a key regulator of DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:37439366, PubMed:37891173, PubMed:39636933). Regulates HR by mediating disassembly of RAD51 filaments from DNA and chromatin, thereby preventing DNA damage-independent RAD51 loading and persistent DNA accumulation of RAD51 recombinases (PubMed:39636933). Also regulates HR during meiosis by mediating dissociation of DMC1 filaments from DNA (PubMed:37439366, PubMed:37891173, PubMed:39147779). May regulate osteoblast proliferation and differentiation (PubMed:17352653). {ECO:0000269|PubMed:17352653, ECO:0000269|PubMed:37439366, ECO:0000269|PubMed:37891173, ECO:0000269|PubMed:39147779, ECO:0000269|PubMed:39636933}.
uniprot
proteins
mass_dalton
74850
uniprot
proteins
mutagenesis
MUTAGEN 114; /note="D->C: Abolished ability to dissociate RAD51 filaments."; /evidence="ECO:0000269|PubMed:39636933"; MUTAGEN 456; /note="K->A: Abolished nucleotid-binding, preventing ability to dissociate RAD51 filaments."; /evidence="ECO:0000269|PubMed:39636933
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
11017077
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17352653
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22110678
uniprot
proteins
pubmed
37439366
uniprot
proteins
pubmed
37891173
uniprot
proteins
pubmed
39147779
uniprot
proteins
pubmed
39636933
uniprot
proteins
sequence_length
683
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q6PIW4}. Nucleus {ECO:0000250|UniProtKB:Q6PIW4}. Cytoplasm {ECO:0000269|PubMed:22110678}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:22110678}. Note=Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. {ECO:0000250|UniProtKB:Q6PIW4}.
uniprot
proteins