Bicd2
entrez
76895
canonical
uniprot
Q921C5
canonical
ensembl
ENSMUSG00000037933
resolver
ensp
ENSMUSP00000039394
resolver
ensp
ENSMUSP00000105711
resolver
ensp
ENSMUSP00000105712
resolver
enst
ENSMUST00000110084
resolver
genesymbol
Bicd2
resolver
genesymbol_syn
Kiaa0699
resolver
uniprot
D3Z390
resolver
uniprot
Q80TU1
resolver
uniprot
Q8BTE3
resolver
uniprot
Q9DCL3
resolver
uniprot_entry
BICD2_MOUSE
resolver
uniprot_entry
D3Z390_MOUSE
resolver
uniprot_sec
Q80TU1
resolver
uniprot_sec
Q8BTE3
resolver
uniprot_sec
Q9DCL3
resolver
amino_acid_sequence
MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLTSVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNNLRKELSHYMSINDSFYTSHLQVSLDGLKFSDDTVTAEPNNDAEALVNGFEHSGLVKSSLDNKTSTPRKDGLAPPSPSLVSDLLSELHISEIQKLKQQLVQMEREKVGLLATLQDTQKQLEQARGTLSEQHEKVNRLTENLSALRRLQAGKERQTSLDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKISLLEKASHQDRELLAHLEKELKKVSDVAGETQGSLNVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGKAGRTSPEGRGRRSPVLLPKGLLATEVGRADGGTGDNSPSPSSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGRSKAASKAKPASPSL
uniprot
proteins
function
FUNCTION: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:11483508, PubMed:22956769, PubMed:24986880, PubMed:25035494). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form (PubMed:25962623). Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:12447383, PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (PubMed:20386726). {ECO:0000269|PubMed:11483508, ECO:0000269|PubMed:12447383, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:22956769, ECO:0000269|PubMed:24986880, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:25962623}.
uniprot
proteins
mass_dalton
93391
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NEK9 in vitro. {ECO:0000250|UniProtKB:Q8TD16}.
uniprot
proteins
protein_family
BicD family
uniprot
proteins
pubmed
11483508
uniprot
proteins
pubmed
12447383
uniprot
proteins
pubmed
12522145
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
20386726
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22956769
uniprot
proteins
pubmed
23664119
uniprot
proteins
pubmed
24986880
uniprot
proteins
pubmed
25035494
uniprot
proteins
pubmed
25962623
uniprot
proteins
pubmed
26968983
uniprot
proteins
sequence_length
820
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:11483508, ECO:0000269|PubMed:12447383, ECO:0000269|PubMed:25962623}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11483508}. Cytoplasm {ECO:0000250|UniProtKB:Q8TD16}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q8TD16}. Nucleus envelope {ECO:0000250|UniProtKB:Q8TD16}. Note=In interphase cells mainly localizes to the Golgi complex and colocalizes with dynactin at microtubule plus ends (PubMed:11483508). Localizes to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae in a RANBP2-dependent manner during G2 phase of the cell cycle (By similarity). {ECO:0000250|UniProtKB:Q8TD16, ECO:0000269|PubMed:11483508}.
uniprot
proteins