IL1RL1
entrez
9173
canonical
uniprot
Q01638
canonical
ensembl
ENSG00000115602
resolver
ensp
ENSP00000233954
resolver
ensp
ENSP00000310371
resolver
ensp
ENSP00000384822
resolver
ensp
ENSP00000578586
resolver
ensp
ENSP00000693312
resolver
genesymbol
IL1RL1
resolver
genesymbol_syn
DER4
resolver
genesymbol_syn
ST2
resolver
genesymbol_syn
T1
resolver
hgnc
HGNC:5998
resolver
uniprot
A8K6B3
resolver
uniprot
B4E0I3
resolver
uniprot
Q53TU7
resolver
uniprot
Q8NEJ3
resolver
uniprot
Q9ULV7
resolver
uniprot
Q9UQ44
resolver
uniprot_entry
ILRL1_HUMAN
resolver
uniprot_sec
A8K6B3
resolver
uniprot_sec
B4E0I3
resolver
uniprot_sec
Q53TU7
resolver
uniprot_sec
Q8NEJ3
resolver
uniprot_sec
Q9ULV7
resolver
uniprot_sec
Q9UQ44
resolver
amino_acid_sequence
MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPIDHHSIYCIIAVCSVFLMLINVLVIILKMFWIEATLLWRDIAKPYKTRNDGKLYDAYVVYPRNYKSSTDGASRVEHFVHQILPDVLENKCGYTLCIYGRDMLPGEDVVTAVETNIRKSRRHIFILTPQITHNKEFAYEQEVALHCALIQNDAKVILIEMEALSELDMLQAEALQDSLQHLMKVQGTIKWREDHIANKRSLNSKFWKHVRYQMPVPSKIPRKASSLTPLAAQKQ
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP (PubMed:35238669). Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable) (PubMed:16286016). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity). {ECO:0000250|UniProtKB:P14719, ECO:0000269|PubMed:16286016, ECO:0000269|PubMed:35238669, ECO:0000305|PubMed:19836339}.; FUNCTION: [Isoform B]: Inhibits IL-33 signaling. {ECO:0000250|UniProtKB:P14719}.
uniprot
proteins
mass_dalton
63358
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated at Lys-321 in a FBXL19-mediated manner; leading to proteasomal degradation. Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response (PubMed:35238669). {ECO:0000250|UniProtKB:P14719, ECO:0000269|PubMed:35238669}.
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
10527832
uniprot
proteins
pubmed
10936050
uniprot
proteins
pubmed
11478810
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
1482686
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16286016
uniprot
proteins
pubmed
19508382
uniprot
proteins
pubmed
19836339
uniprot
proteins
pubmed
23319592
uniprot
proteins
pubmed
23980170
uniprot
proteins
pubmed
35238669
uniprot
proteins
sequence_length
556
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform C]: Cell membrane.; SUBCELLULAR LOCATION: [Isoform B]: Secreted.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11478810}; Single-pass type I membrane protein {ECO:0000269|PubMed:11478810}.
uniprot
proteins
transmembrane_region
TRANSMEM 329..349; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins