KSR2
entrez
283455
canonical
uniprot
Q6VAB6
canonical
ensembl
ENSG00000171435
resolver
ensp
ENSP00000339952
resolver
genesymbol
KSR2
resolver
hgnc
HGNC:18610
resolver
uniprot
A0PJT2
resolver
uniprot
Q3B828
resolver
uniprot
Q8N775
resolver
uniprot_entry
KSR2_HUMAN
resolver
uniprot_sec
A0PJT2
resolver
uniprot_sec
Q3B828
resolver
uniprot_sec
Q8N775
resolver
activity_regulation
ACTIVITY REGULATION: Kinase activity is inhibited by ASC24. {ECO:0000269|PubMed:21441910}.
uniprot
proteins
amino_acid_sequence
MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. {ECO:0000269|PubMed:12975377, ECO:0000269|PubMed:16039990, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126}.
uniprot
proteins
mass_dalton
107632
uniprot
proteins
mutagenesis
MUTAGEN 718; /note="R->H: Impairs formation of heterotetramers with MAP2K1, but not the formation of heterodimers."; /evidence="ECO:0000269|PubMed:21441910"; MUTAGEN 786; /note="D->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:21441910"; MUTAGEN 879; /note="A->L: Impairs MAP2K1 binding."; /evidence="ECO:0000269|PubMed:21441910
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-474 by MARK3. {ECO:0000250}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
12975377
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16039990
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
21441910
uniprot
proteins
pubmed
29433126
uniprot
proteins
sequence_length
950
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
uniprot
proteins