Scnn1a
entrez
25122
canonical
uniprot
P37089
canonical
ensembl
ENSRNOG00000019368
resolver
ensp
ENSRNOP00000061813
resolver
enst
ENSRNOT00000067271
resolver
genesymbol
Scnn1a
resolver
genesymbol_syn
RCNaCh
resolver
genesymbol_syn
RCNaCh1
resolver
genesymbol_syn
Renac
resolver
uniprot
B8QP47
resolver
uniprot
F7FGR0
resolver
uniprot
Q64593
resolver
uniprot
Q6IRJ1
resolver
uniprot
Q9QUI4
resolver
uniprot_entry
F7FGR0_RAT
resolver
uniprot_entry
Q6IRJ1_RAT
resolver
uniprot_entry
SCNNA_RAT
resolver
uniprot_sec
B8QP47
resolver
uniprot_sec
Q64593
resolver
uniprot_sec
Q9QUI4
resolver
activity_regulation
ACTIVITY REGULATION: Originally identified and characterized by its inhibition by the diuretic drug amiloride. {ECO:0000269|PubMed:8188647, ECO:0000269|PubMed:8382172, ECO:0000269|PubMed:9118951}.
uniprot
proteins
amino_acid_sequence
MLDHTRAPELNIDLDLHASNSPKGSMKGNQFKEQDPCPPQPMQGLGKGDKREEQGLGPEPSAPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFALLFEEYLSYPVSLNINLNSDKLVFPAVTVCTLNPYRYTEIKEELEELDRITEQTLFDLYKYNSSYTRQAGARRRSSRDLLGAFPHPLQRLRTPPPPYSGRTARSGSSSVRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLSDTSPALEEEALGNFIFTCRFNQAPCNQANYSKFHHPMYGNCYTFNDKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYRKQSSWGYCYYKLQGAFSLDSLGCFSKCRKPCSVINYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLLMLLRRFRSRYWSPGRGARGAREVASTPASSFPSRFCPHPTSPPPSLPQQGMTPPLALTAPPPAYATLGPSAPPLDSAAPDCSACALAAL
uniprot
proteins
function
FUNCTION: This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:8188647, PubMed:9118951). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:8382172, PubMed:9118951). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance (By similarity). {ECO:0000250|UniProtKB:P37088, ECO:0000269|PubMed:8382172, ECO:0000269|PubMed:9118951}.
uniprot
proteins
mass_dalton
78888
uniprot
proteins
mutagenesis
MUTAGEN 588; /note="S->I: Changes function of the channel including conductance, gating, selectivity and voltage dependence."; /evidence="ECO:0000269|PubMed:7744818"; MUTAGEN 592; /note="S->T: Changes function of the channel including conductance, gating, selectivity and voltage dependence."; /evidence="ECO:0000269|PubMed:7744818
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Can be ubiquitinated at multiple sites and undergo monoubiquitination and polyubiquitination. Ubiquitination by NEDD4 or NEDD4L inhibits the ENaC channel through endocytosis, intracellular retention and degradation of its individual subunits. {ECO:0000269|PubMed:11323714, ECO:0000269|PubMed:12424229, ECO:0000269|PubMed:12654927, ECO:0000269|PubMed:14556380, ECO:0000269|PubMed:8665844, ECO:0000269|PubMed:9351815}.; PTM: N-glycosylated. {ECO:0000269|PubMed:11773057}.; PTM: ENaC is activated through the proteolytic maturation of its subunits. Furin cleaves the SCNN1A subunit, which results in a stepwise increase in the open probability of the channel due to the release of an inhibitory tract (By similarity). BPIFA1, which is recruited by the SCNN1B subunit, prevents the proteolytic activation of ENaC (By similarity). {ECO:0000250|UniProtKB:P37088, ECO:0000250|UniProtKB:Q61180}.
uniprot
proteins
protein_family
Amiloride-sensitive sodium channel (TC 1.A.6) family
uniprot
proteins
protein_family
SCNN1A subfamily
uniprot
proteins
pubmed
10226074
uniprot
proteins
pubmed
11323714
uniprot
proteins
pubmed
11352848
uniprot
proteins
pubmed
11773057
uniprot
proteins
pubmed
12424229
uniprot
proteins
pubmed
12654927
uniprot
proteins
pubmed
14556380
uniprot
proteins
pubmed
29453757
uniprot
proteins
pubmed
7744818
uniprot
proteins
pubmed
7929098
uniprot
proteins
pubmed
8175716
uniprot
proteins
pubmed
8188647
uniprot
proteins
pubmed
8381523
uniprot
proteins
pubmed
8382172
uniprot
proteins
pubmed
8665844
uniprot
proteins
pubmed
9039092
uniprot
proteins
pubmed
9118951
uniprot
proteins
pubmed
9351815
uniprot
proteins
sequence_length
698
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11352848, ECO:0000269|PubMed:11773057, ECO:0000269|PubMed:8188647, ECO:0000269|PubMed:9118951}; Multi-pass membrane protein {ECO:0000269|PubMed:7929098, ECO:0000269|PubMed:8175716}. Cell projection, cilium {ECO:0000250|UniProtKB:P37088}. Cytoplasmic granule {ECO:0000250|UniProtKB:P37088}. Cytoplasm {ECO:0000269|PubMed:29453757}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:29453757}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:29453757}. Note=In multi-ciliated cells, located on cilia. In non-ciliated epithelial cells, restricted to apical surfaces. In epidermis, located nearly uniformly in the cytoplasm in a granular distribution. In sebaceous glands, observed only in the cytoplasmic space in between the lipid vesicles. In eccrine sweat glands, mainly located at the apical surface of the cells facing the lumen (By similarity). In skin, in arrector pili muscle cells and in adipocytes, located in the cytoplasm and colocalized with actin fibers (By similarity). In spermatogonia, spermatocytes and round spermatids, located in the cytoplasm (PubMed:29453757). Prior to spermiation, location shifts from the cytoplasm to the spermatid tail (PubMed:29453757). In spermatozoa, localizes at the acrosome and the central region of the sperm flagellum (PubMed:29453757). {ECO:0000250|UniProtKB:P37088, ECO:0000269|PubMed:11773057, ECO:0000269|PubMed:29453757}.
uniprot
proteins
transmembrane_region
TRANSMEM 111..131; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 590..610; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins