Dynlt1
entrez
83462
canonical
uniprot
Q9Z336
canonical
ensembl
ENSRNOG00000018207
resolver
ensp
ENSRNOP00000024656
resolver
enst
ENSRNOT00000024656
resolver
genesymbol
Dynlt1
resolver
genesymbol_syn
Tctel1
resolver
genesymbol_syn
Tctex-1
resolver
genesymbol_syn
Tctex1
resolver
uniprot
B2RYR9
resolver
uniprot_entry
B2RYR9_RAT
resolver
uniprot_entry
DYLT1_RAT
resolver
amino_acid_sequence
MEDFQASEETAFVVDEVSNIVKEAIESAIGGNAYQHSKVNQWTTNVVEQTLSQLTKLGKPFKYIVTCVIMQKNGAGLHTASSCFWDSSTDGSCTVRWENKTMYCIVSAFGLSI
uniprot
proteins
function
FUNCTION: Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. {ECO:0000250|UniProtKB:A4VEB3}.; FUNCTION: Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. Required for neurite outgrowth. The function in neurogenesis may be regulated by association with a G protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling (By similarity). Involved in the regulation of mitotic spindle orientation. {ECO:0000250|UniProtKB:P63172, ECO:0000269|PubMed:15992542, ECO:0000269|PubMed:17491591}.
uniprot
proteins
mass_dalton
12452
uniprot
proteins
mutagenesis
MUTAGEN 94; /note="T->A: No effect on interaction with dynein intermediate chain (DYNC1I1 or DYNC1I2)."; /evidence="ECO:0000269|PubMed:15992542"; MUTAGEN 94; /note="T->E: Impairs interaction with dynein intermediate chain (DYNC1I1 or DYNC1I2)."; /evidence="ECO:0000269|PubMed:15992542
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by BMPR2. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release.
uniprot
proteins
protein_family
Dynein light chain Tctex-type family
uniprot
proteins
pubmed
11746667
uniprot
proteins
pubmed
12591166
uniprot
proteins
pubmed
15992542
uniprot
proteins
pubmed
17491591
uniprot
proteins
pubmed
9804756
uniprot
proteins
sequence_length
113
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to mitotic spindles. {ECO:0000250}.
uniprot
proteins