Cdt1
entrez
67177
canonical
uniprot
Q8R4E9
canonical
ensembl
ENSMUSG00000006585
resolver
ensp
ENSMUSP00000006760
resolver
enst
ENSMUST00000006760
resolver
genesymbol
Cdt1
resolver
genesymbol_syn
Ris2
resolver
uniprot
Q8BUQ1
resolver
uniprot
Q8BX29
resolver
uniprot
Q8R3V0
resolver
uniprot
Q8R4E8
resolver
uniprot_entry
CDT1_MOUSE
resolver
uniprot_sec
Q8BUQ1
resolver
uniprot_sec
Q8BX29
resolver
uniprot_sec
Q8R3V0
resolver
uniprot_sec
Q8R4E8
resolver
amino_acid_sequence
MAQSRVTDFYACRRPGLTTPRAKSICLTPSPGGLVAPAFTRSSSRKRARPPAEPGSDQPAPLARRRLRLPGLDSCPSSLPEPSSPAEPSPPADPSPPADPGSPVCPSPVKRTKSTTVYVGQQPGKIPSEDSVSELQSCLRRARKLGAQARALRARVQENAVEPSTPDAKVPTEQPCVEKAPAYQRFHALAQPGLPGLVLPYKYQVLVEMFRSMDTIVSMLHNRSETVTFAKVKQGVQEMMRKRFEERNVGQIKTVYPTSYRFRQECNVPTFKDSIKRSDYQLTIEPLLGQEAGGATQLTATCLLQRRQVFRQNLVERVKEQHKVFLASLNPPMAVPDDQLTRWHPRFNVDEVPDIEPAELPQPPVTEKLTTAQEVLARARSLMTPKMEKALSNLALRSAEPGSPGTSTPPLPATPPATPPAASPSALKGVSQALLERIRAKEVQKQLARMTRCPEQELRLQRLERLPELARVLRNVFVSERKPALTMEVVCARMVDSCQTALSPGEMEKHLVLLAELLPDWLSLHRIRTDTYVKLDKAVDLAGLTARLAHHVHAEGL
uniprot
proteins
function
FUNCTION: Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC). Required also for mitosis by promoting stable kinetochore-microtubule attachments (By similarity). Potential oncogene (PubMed:11850834). {ECO:0000250|UniProtKB:Q9H211, ECO:0000269|PubMed:11850834, ECO:0000269|PubMed:12192004, ECO:0000269|PubMed:14993212}.
uniprot
proteins
mass_dalton
61510
uniprot
proteins
post_translational_modification
PTM: Two independent E3 ubiquitin ligase complexes, SCF(SKP2) and the DCX(DTL) complex, mediated CDT1 degradation in S phase. Ubiquitinated by the DCX(DTL) complex, in response to DNA damage, leading to its degradation. Ubiquitination by the DCX(DTL) complex is necessary to ensure proper cell cycle regulation and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation. Phosphorylation at Thr-28 by CDK2 targets CDT1 for ubiquitynation by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation. The interaction with GMNN protects it against ubiquitination. Deubiquitinated by USP37. Ubiquitinated and degraded by the SCF(FBXO31) complex during the G2 phase to prevent re-replication. {ECO:0000250|UniProtKB:Q9H211}.; PTM: Phosphorylation by cyclin A-dependent kinases at Thr-28 targets CDT1 for ubiquitynation by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation. Phosphorylated at Thr-28 by MAPK8/JNK1, which blocks replication licensing in response to stress. Binding to GMNN is not affected by phosphorylation (PubMed:14993212). {ECO:0000250|UniProtKB:Q9H211, ECO:0000269|PubMed:14993212}.
uniprot
proteins
protein_family
Cdt1 family
uniprot
proteins
pubmed
11850834
uniprot
proteins
pubmed
12192004
uniprot
proteins
pubmed
14993212
uniprot
proteins
pubmed
15286659
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15811859
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
557
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14993212}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9H211}. Note=Transiently localizes to kinetochores during prometaphase and metaphase. {ECO:0000250|UniProtKB:Q9H211}.
uniprot
proteins