CBLN2
entrez
147381
canonical
uniprot
Q8IUK8
canonical
ensembl
ENSG00000141668
resolver
ensp
ENSP00000269503
resolver
ensp
ENSP00000463771
resolver
ensp
ENSP00000551409
resolver
ensp
ENSP00000551410
resolver
ensp
ENSP00000551411
resolver
ensp
ENSP00000641449
resolver
ensp
ENSP00000641450
resolver
enst
ENST00000269503
resolver
enst
ENST00000585159
resolver
enst
ENST00000881350
resolver
enst
ENST00000881351
resolver
enst
ENST00000881352
resolver
enst
ENST00000971390
resolver
enst
ENST00000971391
resolver
genesymbol
CBLN2
resolver
hgnc
HGNC:1544
resolver
uniprot
Q53Z56
resolver
uniprot_entry
CBLN2_HUMAN
resolver
uniprot_sec
Q53Z56
resolver
amino_acid_sequence
MQAPGRGPLGLRLMMPGRRGALREPGGCGSCLGVALALLLLLLPACCPVRAQNDTEPIVLEGKCLVVCDSSPSADGAVTSSLGISVRSGSAKVAFSATRSTNHEPSEMSNRTMTIYFDQVLVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYNRQTIQVSLMQNGYPVISAFAGDQDVTREAASNGVLLLMEREDKVHLKLERGNLMGGWKYSTFSGFLVFPL
uniprot
proteins
function
FUNCTION: Acts as a synaptic organizer in specific subsets of neurons in the brain. Essential for long-term maintenance but not establishment of excitatory synapses. Functions as part of a trans-synaptic complex by binding to postsynaptic GRID1 and presynaptic neurexins. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN1B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic NMDAR response. NRXN3B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic AMPAR response. {ECO:0000250|UniProtKB:Q8BGU2}.
uniprot
proteins
mass_dalton
24084
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8BGU2}.
uniprot
proteins