SPRY2
entrez
10253
canonical
uniprot
O43597
canonical
ensembl
ENSG00000136158
resolver
ensp
ENSP00000366306
resolver
ensp
ENSP00000366308
resolver
ensp
ENSP00000579675
resolver
ensp
ENSP00000579676
resolver
ensp
ENSP00000579677
resolver
ensp
ENSP00000579678
resolver
ensp
ENSP00000579679
resolver
ensp
ENSP00000579680
resolver
ensp
ENSP00000579681
resolver
ensp
ENSP00000589099
resolver
ensp
ENSP00000589100
resolver
ensp
ENSP00000589101
resolver
ensp
ENSP00000589102
resolver
ensp
ENSP00000589103
resolver
ensp
ENSP00000589104
resolver
ensp
ENSP00000589105
resolver
ensp
ENSP00000589106
resolver
ensp
ENSP00000630234
resolver
ensp
ENSP00000630235
resolver
ensp
ENSP00000630236
resolver
enst
ENST00000377102
resolver
enst
ENST00000377104
resolver
enst
ENST00000909616
resolver
enst
ENST00000909617
resolver
enst
ENST00000909618
resolver
enst
ENST00000909619
resolver
enst
ENST00000909620
resolver
enst
ENST00000909621
resolver
enst
ENST00000909622
resolver
enst
ENST00000919040
resolver
enst
ENST00000919041
resolver
enst
ENST00000919042
resolver
enst
ENST00000919043
resolver
enst
ENST00000919044
resolver
enst
ENST00000919045
resolver
enst
ENST00000919046
resolver
enst
ENST00000919047
resolver
enst
ENST00000960175
resolver
enst
ENST00000960176
resolver
enst
ENST00000960177
resolver
genesymbol
SPRY2
resolver
hgnc
HGNC:11270
resolver
uniprot
B2R9J9
resolver
uniprot
Q5T6Z7
resolver
uniprot_entry
SPY2_HUMAN
resolver
uniprot_sec
B2R9J9
resolver
uniprot_sec
Q5T6Z7
resolver
amino_acid_sequence
MEARAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQHSQVHSSARAPLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGSSFSSGPVADGIIRVQPKSELKPGELKPLSKEDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT
uniprot
proteins
disease_involvement
DISEASE: IgA nephropathy 3 (IGAN3) [MIM:616818]: A form of IgA nephropathy, a common primary glomerulonephritis characterized by glomerular sclerosis, interstitial fibrosis, and mesangial glomerular deposits of immunoglobulin A and immunoglobulin G visible on renal biopsies. IgA nephropathy is associated with renal insufficiency that can progress to end-stage renal disease. Proteinuria and hematuria are characteristic clinical presentations. {ECO:0000269|PubMed:25782674}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561). {ECO:0000250|UniProtKB:Q9QXV8, ECO:0000269|PubMed:17974561}.
uniprot
proteins
mass_dalton
34688
uniprot
proteins
mutagenesis
MUTAGEN 115; /note="S->A: Abolishes interaction with GRB2."; /evidence="ECO:0000269|PubMed:17974561"; MUTAGEN 144; /note="P->L: Inhibits cleavage by the prolyl endopeptidase FAP."; /evidence="ECO:0000269|PubMed:21288888"; MUTAGEN 252; /note="R->D: Abolishes interaction with CAV1."; /evidence="ECO:0000269|PubMed:16877379
uniprot
proteins
post_translational_modification
PTM: Cleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro). {ECO:0000269|PubMed:21288888}.
uniprot
proteins
protein_family
Sprouty family
uniprot
proteins
pubmed
10887178
uniprot
proteins
pubmed
12717443
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16877379
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
17974561
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21288888
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25782674
uniprot
proteins
pubmed
29408807
uniprot
proteins
pubmed
9458049
uniprot
proteins
sequence_length
315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10887178}. Cell projection, ruffle membrane {ECO:0000269|PubMed:10887178}. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor). {ECO:0000269|PubMed:10887178}.
uniprot
proteins