Q99PW4
uniprot
Q99PW4
canonical
amino_acid_sequence
MAGTSSEAEAEALAAARERSRLFLSGLELVQQGAEARVFRGRFQGRAAVVKHRFPKSYRHPELEARLGRRRTVQEARALLRCRRAGIAAPVVFFVDYASNCLYMEEIEDSVTVRDYIQSTMETEKDPQCLLDLARRMGQVLAGMHDQDLIHGDLTTSNMLLRRPLAQLHIVLIDFGLSFVSGLPEDKGVDLYVLEKAFLSTHPHTETAFEAFLKSYGASSKKSSPVLKKLDEVRLRGRKRSMVG
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
3.6.-.-
uniprot
proteins
function
FUNCTION: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P53323, ECO:0000250|UniProtKB:Q96S44, ECO:0000250|UniProtKB:Q9UYB9}.
uniprot
proteins
mass_dalton
27394
uniprot
proteins
protein_family
BUD32 family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11546806
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96S44}.
uniprot
proteins