Opn5
entrez
353344
canonical
uniprot
Q6VZZ7
canonical
ensembl
ENSMUSG00000043972
resolver
ensp
ENSMUSP00000063542
resolver
genesymbol
Opn5
resolver
genesymbol_syn
Gpr136
resolver
genesymbol_syn
Pgr12
resolver
uniprot
Q059L5
resolver
uniprot
Q7TQP1
resolver
uniprot
Q80T51
resolver
uniprot
Q8BYI2
resolver
uniprot_entry
OPN5_MOUSE
resolver
uniprot_sec
Q059L5
resolver
uniprot_sec
Q7TQP1
resolver
uniprot_sec
Q80T51
resolver
uniprot_sec
Q8BYI2
resolver
amino_acid_sequence
MALNHTALPQDERLPHYLRDEDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGISVVGKPFTIISCFCHRWVFGWFGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSYGVWLKRKHAYICLAVIWAYASFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASGGGQVFILSILFFCLLLPTAVIVFSYAKIIAKVKSSSKEVAHFDSRIHSSHVLEVKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYRFACCQAGGLRGTKKKSLEDFRLHTVTAVRKSSAVLEIHPESSSRFTSAHVMDGESHSNDGDCGKK
uniprot
proteins
function
FUNCTION: G protein-coupled photoreceptor that selectively activates G(i) protein via light-mediated activation in the retina (PubMed:22043319). Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (PubMed:22043319). Acts as a bistable protein with absorption peaks at 380 nm (UVA light) and 470 nm (blue light), allowing photoreversible regeneration of the cis-retinal chromophore after stimulation (PubMed:22043319). Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake (PubMed:30936473). Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock (PubMed:26392540, PubMed:30240620). Acts as a circadian photoreceptor in the outer ear and vibrissal pads, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle (PubMed:31607531). Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling (PubMed:30936473). Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels (PubMed:30936473). Mediates violet light-accelerated wound healing in corneas, being transiently expressed following physical injury (PubMed:40700017). {ECO:0000269|PubMed:22043319, ECO:0000269|PubMed:26392540, ECO:0000269|PubMed:30240620, ECO:0000269|PubMed:30936473, ECO:0000269|PubMed:31607531, ECO:0000269|PubMed:40700017}.
uniprot
proteins
mass_dalton
42018
uniprot
proteins
post_translational_modification
PTM: Contains one retinal chromophore covalently bound to a lysine residue via a Schiff base. Upon light absorption, the bound 11-cis-retinal isomerizes to all-trans-retinal. Following light exposure, all-trans-retinal is photoreconverted to 11-cis-retinal. {ECO:0000269|PubMed:22043319}.; PTM: It is uncertain whether Cys-315 or Cys-316 is palmitoylated. {ECO:0000305}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Opsin subfamily
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
14623098
uniprot
proteins
pubmed
14623103
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22043319
uniprot
proteins
pubmed
26392540
uniprot
proteins
pubmed
30240620
uniprot
proteins
pubmed
30936473
uniprot
proteins
pubmed
31607531
uniprot
proteins
pubmed
40700017
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:22043319}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 75..95; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 109..129; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 151..171; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 198..218; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 253..273; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins