CHAC1
entrez
79094
canonical
uniprot
Q9BUX1
canonical
ensembl
ENSG00000128965
resolver
ensp
ENSP00000395466
resolver
ensp
ENSP00000484644
resolver
genesymbol
CHAC1
resolver
genesymbol_syn
BOTCH
resolver
hgnc
HGNC:28680
resolver
uniprot
Q0VIA0
resolver
uniprot_entry
CHAC1_HUMAN
resolver
uniprot_sec
Q0VIA0
resolver
amino_acid_sequence
MKQESAAPNTPPTSQSPTPSAQFPRNDGDPQALWIFGYGSLVWRPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDHEGCTWGVAYQVQGEQVSKALKYLNVREAVLGGYDTKEVTFYPQDAPDQPLKALAYVATPQNPGYLGPAPEEAIATQILACRGFSGHNLEYLLRLADFMQLCGPQAQDEHLAAIVDAVGTMLPCFCPTEQALALV
uniprot
proteins
ec_number
4.3.2.7
uniprot
proteins
function
FUNCTION: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366). {ECO:0000269|PubMed:19109178, ECO:0000269|PubMed:22445366, ECO:0000269|PubMed:27913623}.
uniprot
proteins
mass_dalton
24418
uniprot
proteins
protein_family
ChaC subfamily
uniprot
proteins
protein_family
Gamma-glutamylcyclotransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
19109178
uniprot
proteins
pubmed
22445366
uniprot
proteins
pubmed
27913623
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19109178}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8R3J5}.
uniprot
proteins