TPRX2
entrez
503627
canonical
uniprot
P0DV77
canonical
ensembl
ENSG00000259009
resolver
ensp
ENSP00000514106
resolver
ensp
ENSP00000514348
resolver
enst
ENST00000535362
resolver
enst
ENST00000699383
resolver
genesymbol
TPRX2
resolver
hgnc
HGNC:32175
resolver
uniprot
A0A8V8TNP4
resolver
uniprot_entry
A0A8V8TNP4_HUMAN
resolver
uniprot_entry
TPRX2_HUMAN
resolver
amino_acid_sequence
MQDPGHLQGPPLALDPPRRQRQERTVYTESQQKVLEFYFQKDQYPNYDQRLNLAEMLSLREQQLQVWFKNRRAKLARERRLQQQPQRVPGQRGRGARAAPLVPVAAASFPGGPEFPQGRGSWISPQPGPWGVLPAAEPKIYSLPRTWGGPECGTQEGLKAVPAPGPGPIPAPIPGPAQIPGPVPGPAPNLGPMSGPLSVSIPGPIPAPISCPGPIPDPVLGRTLMPGPGSLPTPAPGALWPQSPYASNLSPDTQLYPDFTKLLPLLDRFEESSLSTTTSQYKEEDGFVDKNHSVPRSLLDL
uniprot
proteins
function
FUNCTION: Transcription factor expressed after fertilization required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:27412763, PubMed:36074823). Binds and activates expression of key ZGA marker genes, such as NANOGNB, ZSCAN4, DUXB, KLF5 and DPPA3 (PubMed:36074823). Binds to regulatory DNA sequences containing a 5'-TAATCC-3' sequence motif (PubMed:36074823). {ECO:0000269|PubMed:27412763, ECO:0000269|PubMed:36074823}.
uniprot
proteins
mass_dalton
32608
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
27412763
uniprot
proteins
pubmed
36074823
uniprot
proteins
sequence_length
301
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
uniprot
proteins