Blvra
entrez
116599
canonical
uniprot
P46844
canonical
ensembl
ENSRNOG00000011778
resolver
ensembl
ENSRNOG00055005283
resolver
ensembl
ENSRNOG00060014560
resolver
ensembl
ENSRNOG00065012868
resolver
ensp
ENSRNOP00000015843
resolver
ensp
ENSRNOP00055006440
resolver
ensp
ENSRNOP00060019837
resolver
ensp
ENSRNOP00065016243
resolver
enst
ENSRNOT00000015843
resolver
enst
ENSRNOT00055008491
resolver
enst
ENSRNOT00060024902
resolver
enst
ENSRNOT00065021041
resolver
genesymbol
Blvra
resolver
genesymbol_syn
Blvr
resolver
uniprot
F7EW70
resolver
uniprot
Q6AZ33
resolver
uniprot_entry
BIEA_RAT
resolver
uniprot_entry
F7EW70_RAT
resolver
uniprot_entry
Q6AZ33_RAT
resolver
amino_acid_sequence
MDAEPKRKFGVVVVGVGRAGSVRLRDLKDPRSAAFLNLIGFVSRRELGSLDEVRQISLEDALRSQEIDVAYICSESSSHEDYIRQFLQAGKHVLVEYPMTLSFAAAQELWELAAQKGRVLHEEHVELLMEEFEFLRREVLGKELLKGSLRFTASPLEEERFGFPAFSGISRLTWLVSLFGELSLISATLEERKEDQYMKMTVQLETQNKGLLSWIEEKGPGLKRNRYVNFQFTSGSLEEVPSVGVNKNIFLKDQDIFVQKLLDQVSAEDLAAEKKRIMHCLGLASDIQKLCHQKK
uniprot
proteins
ec_number
1.3.1.24
uniprot
proteins
function
FUNCTION: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:1371282, PubMed:8020496). Does not reduce bilirubin IXbeta (By similarity). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:1371282, PubMed:8020496). NADPH, however, is the probable reactant in biological systems (PubMed:8020496). {ECO:0000250|UniProtKB:P53004, ECO:0000269|PubMed:1371282, ECO:0000269|PubMed:8020496}.
uniprot
proteins
mass_dalton
33566
uniprot
proteins
mutagenesis
MUTAGEN 73; /note="C->A: Loss of activity."; /evidence="ECO:0000269|PubMed:8020496"; MUTAGEN 280; /note="C->A: Reduced activity."; /evidence="ECO:0000269|PubMed:8020496"; MUTAGEN 291; /note="C->A: Reduced activity."; /evidence="ECO:0000269|PubMed:8020496
uniprot
proteins
pathway_participation
PATHWAY: Porphyrin-containing compound metabolism; protoheme degradation.
uniprot
proteins
protein_family
Biliverdin reductase subfamily
uniprot
proteins
protein_family
Gfo/Idh/MocA family
uniprot
proteins
pubmed
10957639
uniprot
proteins
pubmed
12079357
uniprot
proteins
pubmed
1371282
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8020496
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P53004}.
uniprot
proteins