ABHD6
entrez
57406
canonical
uniprot
Q9BV23
canonical
ensembl
ENSG00000163686
resolver
ensp
ENSP00000295962
resolver
ensp
ENSP00000420315
resolver
ensp
ENSP00000527947
resolver
ensp
ENSP00000527948
resolver
ensp
ENSP00000527950
resolver
ensp
ENSP00000527952
resolver
ensp
ENSP00000527953
resolver
ensp
ENSP00000527955
resolver
ensp
ENSP00000527957
resolver
ensp
ENSP00000527958
resolver
ensp
ENSP00000527959
resolver
ensp
ENSP00000527960
resolver
ensp
ENSP00000527961
resolver
ensp
ENSP00000642069
resolver
enst
ENST00000295962
resolver
enst
ENST00000478253
resolver
enst
ENST00000857891
resolver
enst
ENST00000857893
resolver
enst
ENST00000857894
resolver
enst
ENST00000857896
resolver
enst
ENST00000857898
resolver
enst
ENST00000857899
resolver
enst
ENST00000857900
resolver
enst
ENST00000857901
resolver
enst
ENST00000972010
resolver
genesymbol
ABHD6
resolver
hgnc
HGNC:21398
resolver
uniprot
B2R7Y9
resolver
uniprot
Q6ZMF7
resolver
uniprot_entry
ABHD6_HUMAN
resolver
uniprot_sec
B2R7Y9
resolver
uniprot_sec
Q6ZMF7
resolver
amino_acid_sequence
MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYVHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLSIDGQVKRIHQFVECLKLNKKPFHLVGTSMGGQVAGVYAAYYPSDVSSLCLVCPAGLQYSTDNQFVQRLKELQGSAAVEKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNNFYRKLFLEIVSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANCQVELLENCGHSVVMERPRKTAKLIIDFLASVHNTDNNKKLD
uniprot
proteins
ec_number
3.1.1.23
uniprot
proteins
function
FUNCTION: Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015). {ECO:0000250|UniProtKB:Q8R2Y0, ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:26491015}.
uniprot
proteins
mass_dalton
38331
uniprot
proteins
mutagenesis
MUTAGEN 148; /note="S->A: Loss of 2-arachidonoyglycerol hydrolase activity."; /evidence="ECO:0000269|PubMed:22969151
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
22969151
uniprot
proteins
pubmed
26491015
uniprot
proteins
sequence_length
337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:Q8R2Y0}; Single-pass type II membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q8R2Y0}; Single-pass type II membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q8R2Y0}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins