PCSK7
entrez
9159
canonical
uniprot
Q16549
canonical
ensembl
ENSG00000160613
resolver
ensp
ENSP00000325917
resolver
ensp
ENSP00000433841
resolver
ensp
ENSP00000501995
resolver
ensp
ENSP00000599057
resolver
ensp
ENSP00000621033
resolver
ensp
ENSP00000676529
resolver
ensp
ENSP00000676532
resolver
ensp
ENSP00000676533
resolver
ensp
ENSP00000676535
resolver
ensp
ENSP00000697828
resolver
ensp
ENSP00000745750
resolver
enst
ENST00000320934
resolver
enst
ENST00000524507
resolver
enst
ENST00000676339
resolver
enst
ENST00000928998
resolver
enst
ENST00000950974
resolver
genesymbol
PCSK7
resolver
genesymbol_syn
LPC
resolver
genesymbol_syn
PC7
resolver
genesymbol_syn
PC8
resolver
genesymbol_syn
SPC7
resolver
hgnc
HGNC:8748
resolver
uniprot
B0YJ60
resolver
uniprot
Q3C1X1
resolver
uniprot
Q53GM4
resolver
uniprot
Q96FK8
resolver
uniprot
Q9UL57
resolver
uniprot_entry
PCSK7_HUMAN
resolver
uniprot_sec
B0YJ60
resolver
uniprot_sec
Q3C1X1
resolver
uniprot_sec
Q53GM4
resolver
uniprot_sec
Q96FK8
resolver
uniprot_sec
Q9UL57
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by zinc and copper. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAVLAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.
uniprot
proteins
mass_dalton
86247
uniprot
proteins
post_translational_modification
PTM: Cysteine residues in the cytoplasmic tail are probably palmitoylated. {ECO:0000269|PubMed:9341152}.; PTM: N-glycosylated. {ECO:0000269|PubMed:9341152}.
uniprot
proteins
protein_family
Peptidase S8 family
uniprot
proteins
pubmed
10362256
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8564950
uniprot
proteins
pubmed
8615762
uniprot
proteins
pubmed
9341152
uniprot
proteins
sequence_length
785
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Seems to be localized intracellularly to the trans Golgi network. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 668..688; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins