Gucy2d
entrez
113911
canonical
uniprot
P51839
canonical
ensembl
ENSRNOG00000015058
resolver
ensp
ENSRNOP00000020513
resolver
genesymbol
Gucy2d
resolver
genesymbol_syn
Gucy2e
resolver
uniprot
F1M245
resolver
uniprot_entry
GUC2D_RAT
resolver
uniprot_sec
F1M245
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+) (PubMed:11580282). Activated by NCALD in a Ca(2+)-dependent fashion (PubMed:11580282). {ECO:0000269|PubMed:11580282}.
uniprot
proteins
amino_acid_sequence
MAGLQQGCHPEGQDWTAPHWKTCRPCQGPRGLTVRHLRTVSSISVFSVVFWGVLLWADSLSLPAWARETFTLGVLGPWDCDPIFAQALPSMATQLAVDRVNQDASLLLGSQLDFKILPTGCDTPHALATFVAHRNTVAAFIGPVNPGYCPAAALLAQGWGKSLFSWACGAPEGGGALVPTLPSMADVLLSVMRHFGWARLAIVSSHQDIWVTTAQQLATAFRAHGLPIGLITSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTVLLRCARKEGLTDGRLVFLPYDTLLFALPYRNRSYLVLDDDGPLQEAYDAVLTISLDTSPESHAFTATKMRGGTAANLGPEQVSPLFGTIYDAVILLAHALNHSEAHGTGLSGAHLGNHIRALDVAGFSQRIRIDGKGRRLPQYVILDTNGEGSQLVPTHILDVSTQQVQPLGTAVHFPGGSPPARDASCWFDPNTLCIRGVQPLGSLLTLTITCVLALVGGFLAYFIRLGLQQLRLLRGPHRILLTPQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPQSVIQGSTRSVPAFLEHTNVALYQGEWVWLKKFEAGTAPDLRPSSLSLLRKMREMRHENVTAFLGLFVGPEVSAMVLEHCARGSLEDLLRNEDLRLDWTFKASLLLDLIRGLRYLHHRHFPHGRLKSRNCVVDTRFVLKITDHGYAEFLESHCSFRPQPAPEELLWTAPELLRGPRRPWGPGKATFKGDVFSLGIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFKSINQGKKTSVADSMLRMLEKYSQSLEGLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTMFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANMALEILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSRNTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKTGFCRSLPTPLSIQPGDPWQDHINQEIRTGFAKLARVG
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Functions as an olfactory receptor activated by a urine odorant, uroguanylin (PubMed:18178149). Activated as well by the volatile semiochemicals carbon disulfide (CS2) and carbon dioxide (CO2) (By similarity). Has guanylate cyclase activity upon binding of the ligand (PubMed:18178149). Activation of GUCY2D neurons leads to the cGMP-dependent activation of the CNGA3 channels, membrane depolarization and an increase in action potential frequency. Signaling pathways activated by GUCY2D may trigger social behaviors such as acquisition of food preference (By similarity). {ECO:0000250|UniProtKB:A0A0U1RPR8, ECO:0000269|PubMed:18178149}.
uniprot
proteins
mass_dalton
122093
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
11580282
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
18178149
uniprot
proteins
pubmed
7724600
uniprot
proteins
sequence_length
1110
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000269|PubMed:11580282}; Single-pass type I membrane protein {ECO:0000269|PubMed:18178149}. Note=Colocalized with NCALD at the apical region of the cilia (PubMed:11580282). Coexpresses with PDE2 (By similarity). {ECO:0000250|UniProtKB:A0A0U1RPR8, ECO:0000269|PubMed:11580282}.
uniprot
proteins
transmembrane_region
TRANSMEM 476..500; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins