Cers6
entrez
241447
canonical
uniprot
Q8C172
canonical
ensembl
ENSMUSG00000027035
resolver
ensp
ENSMUSP00000028426
resolver
ensp
ENSMUSP00000135604
resolver
enst
ENSMUST00000028426
resolver
enst
ENSMUST00000176018
resolver
genesymbol
Cers6
resolver
genesymbol_syn
Lass6
resolver
uniprot
H3BL08
resolver
uniprot
Q3U817
resolver
uniprot
Q8BV12
resolver
uniprot_entry
CERS6_MOUSE
resolver
uniprot_entry
H3BL08_MOUSE
resolver
uniprot_sec
Q3U817
resolver
uniprot_sec
Q8BV12
resolver
amino_acid_sequence
MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFIAKPCAIALNIQANGPQTAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFSYGVRFLKQTPWLWNTRHCWYNYPYQPLTADLHYYYILELSFYWSLMVSQFTDIKRKDFGIMFLHHLATIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLLQGLNCFWSYLIVKIACKTVSKGKVSKDDRSDIESSSDDEDSEPPGKKPHSSTTTNGTSGTNGYLLTGPCSVDD
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.24
uniprot
proteins
ec_number
2.3.1.291
uniprot
proteins
function
FUNCTION: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:15823095, PubMed:18541923, PubMed:23760501, PubMed:31150623). Can use different sphingoid bases as substrates for ceramide synthesis, such as sphinganine in de novo synthesis, and sphing-4E-enine (sphingosine), (4R)-hydroxysphinganine (phytosphingosine) or sphinga-4E,14Z-dienine in salvage pathways (By similarity). Ceramides generated by CERS6 play a role in inflammatory response (PubMed:22544924).Other fatty acyl-CoAs such as long-chain saturated stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA), myristoyl-CoA (tetradecanoyl-CoA; C14:0-CoA), and monounsaturated oleoyl-CoA (9Z-octadecenoyl-CoA; C18:1-CoA) can also act as acyl donors, but with less efficiency than hexadecanoyl-CoA (PubMed:18541923). Acts as a regulator of metabolism and hepatic lipid accumulation (PubMed:25295788, PubMed:30655217, PubMed:31150623). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (PubMed:31150623). {ECO:0000250|UniProtKB:Q6ZMG9, ECO:0000269|PubMed:15823095, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:22544924, ECO:0000269|PubMed:23760501, ECO:0000269|PubMed:25295788, ECO:0000269|PubMed:30655217, ECO:0000269|PubMed:31150623}.
uniprot
proteins
mass_dalton
44813
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:15823095, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:31150623}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated (PubMed:15823095, PubMed:23760501). Glycosylation on Asn-18 is not necessary for function (PubMed:15823095). {ECO:0000269|PubMed:15823095, ECO:0000269|PubMed:23760501}.; PTM: Acetylated (PubMed:26620563). Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation (PubMed:26620563). {ECO:0000269|PubMed:26620563}.; PTM: Phosphorylated at the C-terminus by CK2. {ECO:0000250|UniProtKB:Q6ZMG9}.
uniprot
proteins
protein_family
Sphingosine N-acyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15823095
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18541923
uniprot
proteins
pubmed
22544924
uniprot
proteins
pubmed
23760501
uniprot
proteins
pubmed
25295788
uniprot
proteins
pubmed
26620563
uniprot
proteins
pubmed
30655217
uniprot
proteins
pubmed
31150623
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15823095}; Multi-pass membrane protein {ECO:0000269|PubMed:15823095}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..55; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q6ZMG9"; TRANSMEM 132..153; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q6ZMG9"; TRANSMEM 178..198; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q6ZMG9"; TRANSMEM 206..224; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q6ZMG9"; TRANSMEM 230..248; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q6ZMG9"; TRANSMEM 262..284; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q6ZMG9"; TRANSMEM 303..323; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q6ZMG9
uniprot
proteins