Crtc3
entrez
70461
canonical
uniprot
Q91X84
canonical
ensembl
ENSMUSG00000030527
resolver
ensp
ENSMUSP00000113540
resolver
ensp
ENSMUSP00000165628
resolver
genesymbol
Crtc3
resolver
genesymbol_syn
Torc3
resolver
uniprot_entry
CRTC3_MOUSE
resolver
amino_acid_sequence
MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHGGSLPNVSQLRNSAPEFQPSLHQADNVRGTRHHGLVERPARNRFHPLHRRSGDKPGRQFDGNAFAASYSSQHLDESWPRQQPPWKEEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYGGGGQSAWPAPYMGFCDGENDGHAEVAAFPGPLKEENLLNVPKPLPKHLWESKEIQSLSGRPRSCDVGGGNAFPHNGQNTGLSPFLGTLNTGGSLPDLTNLHYSAPLPASLDTSDHLFGSMSVGNSVGNLPAAMTHLGIRTSSGLQSSRSNPSIQATLSKMALSSSLKCHPQPSVANASALHPSLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQGFSRQLSATSPLNPYPASQMVTSEQSPLSFLPTDAQAQVSPPPPYPTPQELPQPLLQQPHAQEPPTQQPQAAPSLPQSDFQLLTAQGSALTSFFPDVRFDQQPMRPSPAFPQQVPLVQQSHREPQDSFHLRPNPYSSCGSFPGTILTEDTNSNLFKGLSGGLSGMPEVSLDMDTPFPLEEELQIEPLSLDGLNMLSDSSMGLLDPSVEETFRADRL
uniprot
proteins
function
FUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348, PubMed:30611118). Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348). Acts independently of CREB1 'Ser-133' phosphorylation (By similarity). Enhances the interaction of CREB1 with TAF4 (By similarity). Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR (By similarity). Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). {ECO:0000250|UniProtKB:Q6UUV7, ECO:0000269|PubMed:29211348, ECO:0000269|PubMed:30611118}.
uniprot
proteins
mass_dalton
67027
uniprot
proteins
mutagenesis
MUTAGEN 62; /note="S->A: Reduces interaction with 14-3-3 proteins without affecting the interaction with PPP2R1A; when associated with A-329 and A-370."; /evidence="ECO:0000269|PubMed:30611118"; MUTAGEN 162; /note="S->A: Up-regulates CREB transcription factor activity. Reduces interaction with 14-3-3 proteins. Abolishes interaction with 14-3-3 proteins without affecting the interaction with PPP2R1A; when associated with A-273."; /evidence="ECO:0000269|PubMed:28235073, ECO:0000269|PubMed:30611118"; MUTAGEN 273; /note="S->A: Reduces interaction with 14-3-3 proteins. Abolishes interaction with 14-3-3 proteins without affecting the interaction with PPP2R1A; when associated with A-162."; /evidence="ECO:0000269|PubMed:28235073, ECO:0000269|PubMed:30611118"; MUTAGEN 329; /note="S->A: Reduces interaction with 14-3-3 proteins without affecting the interaction with PPP2R1A; when associated with A-62 and A-370."; /evidence="ECO:0000269|PubMed:30611118"; MUTAGEN 370; /note="S->A: Reduces interaction with 14-3-3 proteins without affecting the interaction with PPP2R1A; when associated with A-62 and A-329."; /evidence="ECO:0000269|PubMed:30611118"; MUTAGEN 391; /note="S->A,E: Abolishes phosphorylation. Abolishes interaction with PPP2CA and PPP2R1A. Slight increase in phosphorylation at Ser-273 and in the interaction with 14-3-3 proteins."; /evidence="ECO:0000269|PubMed:30611118"; MUTAGEN 392; /note="P->A: Abolishes phosphorylation at Ser-391. Abolishes interaction with PPP2CA and PPP2R1A."; /evidence="ECO:0000269|PubMed:30611118"; MUTAGEN 394; /note="T->A: Does not affect phosphorylation at Ser-391 or the interaction with PPP2CA and PPP2R1A."; /evidence="ECO:0000269|PubMed:30611118"; MUTAGEN 396; /note="S->A: Does not affect phosphorylation at Ser-391 or the interaction with PPP2CA and PPP2R1A."; /evidence="ECO:0000269|PubMed:30611118
uniprot
proteins
post_translational_modification
PTM: Phosphorylation/dephosphorylation states of Ser-273 are required for regulating transduction of CREB activity (PubMed:29211348). CRTCs/TORCs are inactive when phosphorylated, and active when dephosphorylated at this site (PubMed:29211348). May be phosphorylated at Ser-391 by MAPK3/ERK1 and/or MAPK1/ERK2 or by some cyclin-dependent kinases such as CDK1,CDK2 or CDK5 (PubMed:30611118). Following adenylyl cyclase activation, dephosphorylated at Ser-162 and Ser-273 resulting in its dissociation from 14-3-3 proteins probably promoting CRTC3 translocation into the nucleus (PubMed:30611118). {ECO:0000269|PubMed:29211348, ECO:0000269|PubMed:30611118}.
uniprot
proteins
protein_family
TORC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28235073
uniprot
proteins
pubmed
29211348
uniprot
proteins
pubmed
30611118
uniprot
proteins
sequence_length
619
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30611118}. Cytoplasm {ECO:0000269|PubMed:30611118}. Note=Appears to be mainly nuclear. Translocates to the nucleus following adenylyl cyclase or MAP kinase activation (PubMed:30611118). {ECO:0000250|UniProtKB:Q6UUV7, ECO:0000269|PubMed:30611118}.
uniprot
proteins