Draxin
entrez
70433
canonical
uniprot
Q6PAL1
canonical
ensembl
ENSMUSG00000029005
resolver
ensp
ENSMUSP00000030862
resolver
enst
ENSMUST00000030862
resolver
genesymbol
Draxin
resolver
uniprot
A2A7G4
resolver
uniprot
B2KFL9
resolver
uniprot
Q8C3D8
resolver
uniprot_entry
DRAXI_MOUSE
resolver
uniprot_sec
A2A7G4
resolver
uniprot_sec
B2KFL9
resolver
uniprot_sec
Q8C3D8
resolver
amino_acid_sequence
MAGCPVLRVPTLFLILLLFPELHTAGTLASGSSARNLPETHSHLPSSALWVSQASHHGRRGLGKKDRGPGRPSRAQEGAVVTATKQASQMTLGQPPAGLLQNKELLLGLTLPYPEKEARSPAWERVKKRGREHKRRRDRLRLHRGRAAIRGPSSLMKKVEPSEDRMLEGTMEESSTSLAPTMFFLTMTDGATPTTEESRILPVTSLRPQTQPRSDGEVMPTLDMALFDWTDYEDLKPEVWPSAKKKEKHWSHFTSDGNETSPAEGDPCDHHQDCLPGTCCDLREHLCTPHNRGLNNKCFDDCMCMEGLRCYAKFHRNRRVTRRKGRCVEPETANGDQGSFINI
uniprot
proteins
function
FUNCTION: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. {ECO:0000255|HAMAP-Rule:MF_03060, ECO:0000269|PubMed:19857465, ECO:0000269|PubMed:23206892}.
uniprot
proteins
mass_dalton
38363
uniprot
proteins
protein_family
Draxin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19150847
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19857465
uniprot
proteins
pubmed
23206892
uniprot
proteins
sequence_length
343
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000255|HAMAP-Rule:MF_03060}.
uniprot
proteins