Bcl2l11
entrez
64547
canonical
uniprot
O88498
canonical
ensembl
ENSRNOG00000016551
resolver
ensp
ENSRNOP00000080342
resolver
genesymbol
Bcl2l11
resolver
genesymbol_syn
Bim
resolver
genesymbol_syn
Bod
resolver
uniprot
O88497
resolver
uniprot
Q9WUI8
resolver
uniprot_entry
B2L11_RAT
resolver
uniprot_sec
O88497
resolver
uniprot_sec
Q9WUI8
resolver
amino_acid_sequence
MAKQPSDVNSECDREGGQLQPAERPPQLRPGAPTSLQTESQGNPDGEGDRCPHGSPQGPLAPPASPGPFATRSPLFIFVRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASIRQSQEEPEDLRPEIRIAQELRRIGDEFNETYTRRAFANDYREAEDHPQMVILQLLRFIFRLVWRRH
uniprot
proteins
function
FUNCTION: Induces apoptosis and anoikis. {ECO:0000269|PubMed:9731710}.
uniprot
proteins
mass_dalton
22056
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-65 by MAPK1/MAPK3 leads interaction with TRIM2 and ubiquitination, followed by proteasomal degradation. Deubiquitination catalyzed by USP27X stabilizes the protein. {ECO:0000250|UniProtKB:O54918}.; PTM: Ubiquitination by TRIM2 following phosphorylation by MAPK1/MAPK3 leads to proteasomal degradation (PubMed:21478148). Conversely, deubiquitination catalyzed by USP27X stabilizes the protein (By similarity). {ECO:0000250|UniProtKB:O54918, ECO:0000269|PubMed:21478148}.
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
21478148
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9731710
uniprot
proteins
sequence_length
196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Mitochondrion {ECO:0000250}. Note=Associated with intracytoplasmic membranes. {ECO:0000250}.
uniprot
proteins