P54708
uniprot
P54708
canonical
activity_regulation
ACTIVITY REGULATION: Up-regulated by K(+) ions in a dose-dependent way. {ECO:0000269|PubMed:10644526, ECO:0000269|PubMed:7560093}.
uniprot
proteins
amino_acid_sequence
MRRKTEIYSVELNGTKDVKPADQRDDKKFKGAKNKDLEPNKSHEKEELKKELDLDDHRLSNTELEQKYGTNIIQGLSSVRATELLARDGPNTLTPPKQTPEIIKFLKQMVGGFSILLWIGAALCWIAFVIQYVNNSASLDNVYLGAILVLVVILTGIFAYYQEAKSTNIMASFSKMIPQQALVIRDAEKKVISAEQLVVGDVVEIKGGDQIPADIRLVFSQGCKVDNSSLTGESEPQARSTEFTHENPLETKNIGFYSTTCLEGTATGIVINTGDRTIIGRIASLASGVGSEKTPIAIEIEHFVHIVAGVAVSIDIIFFITAVCMKYYVLDAIIFLISIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSENQTKQAFDQSSGTWASLSKIITLCNRAEFRPGQESVPIMKRTVVGDASETALLKFSEVILGDVMGIRKRNHKVAEIPFNSTNKFQLSIHETEDPNNKRFLVVMKGAPERILEKCSTIMINGQEQPLDKSSADSFHTAYMELGGLGERVLGFCHLYLPAEQFPQSYIFDVDSVNFPTSNFCFVGLLSMIDPPRSTVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANNETVEDIAKRRNIAVEQVNKREAKAAVVTGMELKDMTPEQLDELLTNYQEIVFARTSPQQKLIIVEGCQRQDAIVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYTLTKNIAELCPFLIYIVAGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKKKDRLVNTQLAIYSYLHIGLMQALGGFLVYFTVYAQQGFWPTSLINLRVAWETDDINDLEDSYGQEWTRYQRKYLEWTGSTAFFVAIMIQQIADLIIRKTRRNSIFQQGLFRNKVIWVGIASQVIVALILSYGLGSVPALSFTMLRVQYWFVAVPHAILIWVYDEMRKLFIRLYPGSWWDKNMYY
uniprot
proteins
ec_number
7.2.2.13
uniprot
proteins
ec_number
7.2.2.19
uniprot
proteins
function
FUNCTION: The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment (PubMed:10644526, PubMed:7560093). Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (By similarity). In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (By similarity). {ECO:0000250|UniProtKB:P54707, ECO:0000250|UniProtKB:Q9Z1W8, ECO:0000269|PubMed:10644526, ECO:0000269|PubMed:7560093}.
uniprot
proteins
mass_dalton
114975
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIC subfamily
uniprot
proteins
pubmed
10644526
uniprot
proteins
pubmed
1320029
uniprot
proteins
pubmed
14749213
uniprot
proteins
pubmed
7560093
uniprot
proteins
pubmed
9446555
uniprot
proteins
pubmed
9872395
uniprot
proteins
pubmed
9950762
uniprot
proteins
sequence_length
1036
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:14749213, ECO:0000269|PubMed:7560093, ECO:0000269|PubMed:9950762}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 301..320; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 333..350; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 785..804; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 815..835; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 856..878; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 931..950; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 965..983; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 999..1019; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins