Iyd
entrez
308129
canonical
uniprot
Q5BK17
canonical
ensembl
ENSRNOG00000016286
resolver
ensembl
ENSRNOG00055021444
resolver
ensembl
ENSRNOG00060000700
resolver
ensembl
ENSRNOG00065002607
resolver
ensp
ENSRNOP00000021893
resolver
ensp
ENSRNOP00055029761
resolver
ensp
ENSRNOP00060000183
resolver
ensp
ENSRNOP00065002401
resolver
enst
ENSRNOT00000021895
resolver
enst
ENSRNOT00055036634
resolver
enst
ENSRNOT00060000795
resolver
enst
ENSRNOT00065003469
resolver
genesymbol
Iyd
resolver
genesymbol_syn
Dehal1
resolver
uniprot_entry
IYD1_RAT
resolver
amino_acid_sequence
MFLLTPVLVAVVCILVIWVFKNADRSLEEKKEEARAQPWVDEDLKDNTEHLQVEEDTEEWQESEESVEHILFSHTRYPEQEMRMRSQEFYELLSKRRSIRFISSEPVPMEVIDNVIKAAGTAPSGAHTEPWTFVVVKDPDMKHKIREIIEEEEEINYMKRMGKRWVTDLKKLRTNWIKEYLDTAPVLILIFKQVHGFAVNGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNCGPRLRVLLGRPSHEKLLVLLPVGYPSRGATVPDLKRKTLDQIMVTV
uniprot
proteins
ec_number
1.21.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine. During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT). The scavanged iodide can then reenter the hormone-producing pathways. Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine. {ECO:0000250|UniProtKB:Q6PHW0}.
uniprot
proteins
mass_dalton
32846
uniprot
proteins
protein_family
Nitroreductase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
285
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6PHW0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q6PHW0}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q6PHW0}.
uniprot
proteins
transmembrane_region
TRANSMEM 1..21; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins