TAX1BP1
entrez
8887
canonical
uniprot
Q86VP1
canonical
ensembl
ENSG00000106052
resolver
ensp
ENSP00000265393
resolver
ensp
ENSP00000379612
resolver
ensp
ENSP00000391907
resolver
ensp
ENSP00000444811
resolver
ensp
ENSP00000541761
resolver
ensp
ENSP00000770941
resolver
genesymbol
TAX1BP1
resolver
genesymbol_syn
T6BP
resolver
hgnc
HGNC:11575
resolver
uniprot
A4D196
resolver
uniprot
B4DKU7
resolver
uniprot
B4DSG5
resolver
uniprot
E7ENV2
resolver
uniprot
O60398
resolver
uniprot
O95770
resolver
uniprot
Q13311
resolver
uniprot
Q9BQG5
resolver
uniprot
Q9UI88
resolver
uniprot_entry
B4DSG5_HUMAN
resolver
uniprot_entry
TAXB1_HUMAN
resolver
uniprot_sec
A4D196
resolver
uniprot_sec
B4DKU7
resolver
uniprot_sec
E7ENV2
resolver
uniprot_sec
O60398
resolver
uniprot_sec
O95770
resolver
uniprot_sec
Q13311
resolver
uniprot_sec
Q9BQG5
resolver
uniprot_sec
Q9UI88
resolver
amino_acid_sequence
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQNVLNFD
uniprot
proteins
function
FUNCTION: Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}.
uniprot
proteins
mass_dalton
90877
uniprot
proteins
mutagenesis
MUTAGEN 114; /note="A->Q: Complete loss of TBK1 and RB1CC1 binding."; /evidence="ECO:0000269|PubMed:33226137"; MUTAGEN 143; /note="V->S: Complete loss of MAP1LC3B binding."; /evidence="ECO:0000269|PubMed:26451915"; MUTAGEN 771; /note="Q->A: Normal affinity for ubiquitin."; /evidence="ECO:0000269|PubMed:27062441"; MUTAGEN 774; /note="E->A: Reduced affinity for ubiquitin."; /evidence="ECO:0000269|PubMed:27062441"; MUTAGEN 775; /note="R->A: Normal affinity for ubiquitin."; /evidence="ECO:0000269|PubMed:27062441"; MUTAGEN 777; /note="V->S: Reduced affinity for ubiquitin."; /evidence="ECO:0000269|PubMed:27062441"; MUTAGEN 778; /note="Q->A: Reduced affinity for ubiquitin."; /evidence="ECO:0000269|PubMed:27062441"; MUTAGEN 781; /note="F->A: Reduced affinity for ubiquitin."; /evidence="ECO:0000269|PubMed:27062441
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation. {ECO:0000269|PubMed:21765415}.
uniprot
proteins
pubmed
10435631
uniprot
proteins
pubmed
10920205
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14530271
uniprot
proteins
pubmed
14697242
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17703191
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21765415
uniprot
proteins
pubmed
21885437
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24239949
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26451915
uniprot
proteins
pubmed
27062441
uniprot
proteins
pubmed
27736772
uniprot
proteins
pubmed
28898289
uniprot
proteins
pubmed
29940186
uniprot
proteins
pubmed
30459273
uniprot
proteins
pubmed
30909570
uniprot
proteins
pubmed
31371777
uniprot
proteins
pubmed
33226137
uniprot
proteins
pubmed
34431698
uniprot
proteins
pubmed
34471133
uniprot
proteins
sequence_length
789
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30909570}. Mitochondrion {ECO:0000269|PubMed:27736772}. Preautophagosomal structure {ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:26451915}.
uniprot
proteins