Esr2
entrez
25149
canonical
uniprot
Q62986
canonical
ensembl
ENSRNOG00000005343
resolver
ensp
ENSRNOP00000040505
resolver
enst
ENSRNOT00000042682
resolver
genesymbol
Esr2
resolver
genesymbol_syn
ERb1
resolver
genesymbol_syn
ERb2
resolver
genesymbol_syn
Erbeta
resolver
genesymbol_syn
Nr3a2
resolver
uniprot
A0A9K3Y725
resolver
uniprot
A0A9K3Y862
resolver
uniprot
F7F997
resolver
uniprot
O35784
resolver
uniprot
O35785
resolver
uniprot
O55015
resolver
uniprot
O55016
resolver
uniprot
O70195
resolver
uniprot
Q59IV9
resolver
uniprot
Q9R185
resolver
uniprot_entry
A0A9K3Y725_RAT
resolver
uniprot_entry
A0A9K3Y862_RAT
resolver
uniprot_entry
ESR2_RAT
resolver
uniprot_entry
Q59IV9_RAT
resolver
uniprot_sec
F7F997
resolver
uniprot_sec
O35784
resolver
uniprot_sec
O35785
resolver
uniprot_sec
O55015
resolver
uniprot_sec
O55016
resolver
uniprot_sec
O70195
resolver
uniprot_sec
Q9R185
resolver
amino_acid_sequence
MEIKNSPSSLSSPASYNCSQSILPLEHGPIYIPSSYVDNRHEYSAMTFYSPAVMNYSVPGSTSNLDGGPVRLSTSPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLSGSSCASPVTSPNAKRDAHFCPVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSSSEQVHCLSKAKRNGGHAPRVKELLLSTLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLASANQEAESSRKLTHLLNAVTDALVWVIAKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYDLLLEMLNAHTLRGYKSSISGSECSSTEDSKNKESSQNLQSQ
uniprot
proteins
function
FUNCTION: [Isoform 1]: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. {ECO:0000250|UniProtKB:Q92731, ECO:0000269|PubMed:8650195, ECO:0000269|PubMed:9600083}.; FUNCTION: [Isoform 2]: Lacks ligand binding affinity and suppresses ESR1/ER-alpha and ESR2 isoform 1/ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action. {ECO:0000269|PubMed:9600083}.; FUNCTION: [Isoform 3]: Unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. {ECO:0000269|PubMed:9492041}.; FUNCTION: [Isoform 4]: Unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. {ECO:0000269|PubMed:9492041}.
uniprot
proteins
mass_dalton
59152
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-87 and Ser-105 recruits NCOA1. {ECO:0000250}.
uniprot
proteins
protein_family
NR3 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
11818503
uniprot
proteins
pubmed
19423554
uniprot
proteins
pubmed
21808025
uniprot
proteins
pubmed
8650195
uniprot
proteins
pubmed
9492041
uniprot
proteins
pubmed
9600083
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92731}.
uniprot
proteins