Cep128
entrez
75216
canonical
uniprot
Q8BI22
canonical
ensembl
ENSMUSG00000061533
resolver
ensp
ENSMUSP00000115679
resolver
ensp
ENSMUSP00000222055
resolver
genesymbol
Cep128
resolver
genesymbol_syn
4930534B04Rik
resolver
uniprot
B7ZNX8
resolver
uniprot_entry
B7ZNX8_MOUSE
resolver
uniprot_entry
CE128_MOUSE
resolver
amino_acid_sequence
MAESSSDSDHVRYRDGLSRWATRSFQRGVGSHSTVDVTAKVNTITNTLQDTTRNLRHVDQMLGRYREYSTGQAGAVGQLKEDLEQSINQLRSQRLRRSSGGRSVSVTSLSASDLDGGAVTENLRFAPTSPLKDYDLQGIKRNRFRTGVRFVSETDDMVQLHTFHQSLRDLSSEQVRLGDDLNRELFRRSRSDAETKRVLEELTGKLNEVQKPDVVSDRVERRLQEIEREMRLERELVERRHDQLGLVSLKLQEALKKQEAKADENEDVIKRKLRQSETEKSQLEQELEISRRLLSQSESNRETLLHQVEELRTQLIKAEGDQRGLQHQVPCISKQPLSHQDDQGDDRRFRRGVEREKLSLEKQMADLRVQLNFNSMASELEEVKRCMERKDQEKATLAAQIENLTRDLENREKQQLQMLDQLTEIQNHFETCEANRKRTDLQLSELSQHAEEATKQAEHYLSEFQRSETLREEAEKRREDLKAKAQESIRQWKLKHKKLERSMEKQAETLVQLTEKNNQFIKERDELKSQLCAALQQIENLRKELNDVLSKRALQEEELHCKEKKLNDIESHQAELELEVKNSLDTIHRLENELKRQSKSQSQIKAEKIHLEEEITELKKSQSQDKVKLLEMQESIKDLSAIRADLANKLAEEEKAKKAVFRDLSELTAQVKSKEEETATAITQLKLERDVHQRELEDLSSSLESVKLKHEQNIQELMKHFKKEKSEAESHIRMLKAESLEDKNMAKAHLGQLEKLKSQCEKLTEELTHTENENKKLKLKYQSLKEELDKKEKYISTEEEHLRRMEESRLHLKDQLLCLETEQESILGVIGKEIDEACKTFSRDSLEKLKVLTSGPQLHYDPHRWLAESKTKLQWLCEELKERESRERSMRQQLAACRQELRELTEHKESELLCLFEHIERQEQLLEEFHQEKRGLLEETQRKDEEVETLQDRVNALQMSTRVALDHLESVPEKLSLLEDFKDFRGASSLSEKTDGRYSKYSLHGDSVQQRRDDTKPRIKSFRDDRPLSAGSHAHGLDHSSSCQDHSRFLSSPQFSHSLPVFTKRTIATDPASIEGDTTSLPANGTSPQSKKEEHEIKKYKK
uniprot
proteins
function
FUNCTION: Is involved in the negative regulation of ciliogenesis and plays a role in spermatogenesis (PubMed:35296684). Contributes to the regulation of the TGFB/BMP signaling pathway at the primary cilium, where it is required for ciliary localization of RAB11A, likely affecting the trafficking and regulation of TGFB/BMP pathway components (By similarity). Required, together with ODF2, for the formation of the subdistal appendage of the centriole (PubMed:30623524). {ECO:0000250|UniProtKB:Q6ZU80, ECO:0000269|PubMed:30623524, ECO:0000269|PubMed:35296684}.
uniprot
proteins
mass_dalton
128503
uniprot
proteins
mutagenesis
MUTAGEN 222; /note="R->Q: Homozygous knockin males have impaired spermatogenesis, reduced sperm count and motility, and abnormal sperm morphology."; /evidence="ECO:0000269|PubMed:35296684
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30623524
uniprot
proteins
pubmed
35296684
uniprot
proteins
sequence_length
1102
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:30623524, ECO:0000269|PubMed:35296684}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q6ZU80}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q6ZU80}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q6ZU80}. Note=Localized to the subdistal appendage of the mother centriole (PubMed:30623524). Localized to the distal end of ciliary basal body (By similarity). {ECO:0000250|UniProtKB:Q6ZU80, ECO:0000269|PubMed:30623524}.
uniprot
proteins