MAP2
entrez
4133
canonical
uniprot
P11137
canonical
ensembl
ENSG00000078018
resolver
ensp
ENSP00000199940
resolver
ensp
ENSP00000353508
resolver
ensp
ENSP00000355290
resolver
ensp
ENSP00000376032
resolver
ensp
ENSP00000392164
resolver
ensp
ENSP00000501117
resolver
ensp
ENSP00000507035
resolver
ensp
ENSP00000515868
resolver
ensp
ENSP00000577302
resolver
ensp
ENSP00000577303
resolver
ensp
ENSP00000577304
resolver
ensp
ENSP00000577306
resolver
ensp
ENSP00000577312
resolver
ensp
ENSP00000577314
resolver
ensp
ENSP00000577317
resolver
ensp
ENSP00000577318
resolver
ensp
ENSP00000577319
resolver
ensp
ENSP00000608245
resolver
ensp
ENSP00000628320
resolver
ensp
ENSP00000628328
resolver
enst
ENST00000704357
resolver
genesymbol
MAP2
resolver
hgnc
HGNC:6839
resolver
uniprot
A0A024R3Z1
resolver
uniprot
A0A024R431
resolver
uniprot
Q17S04
resolver
uniprot
Q6NYC5
resolver
uniprot
Q8IUX2
resolver
uniprot
Q99975
resolver
uniprot
Q99976
resolver
uniprot_entry
A0A024R3Z1_HUMAN
resolver
uniprot_entry
MTAP2_HUMAN
resolver
uniprot_entry
Q6NYC5_HUMAN
resolver
uniprot_sec
A0A024R431
resolver
uniprot_sec
Q17S04
resolver
uniprot_sec
Q8IUX2
resolver
uniprot_sec
Q99975
resolver
uniprot_sec
Q99976
resolver
amino_acid_sequence
MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRESVHESIDTMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEEQIEKVKATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVVEDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL
uniprot
proteins
function
FUNCTION: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
uniprot
proteins
mass_dalton
199526
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity). {ECO:0000250|UniProtKB:P15146, ECO:0000250|UniProtKB:P20357}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15536091
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2455776
uniprot
proteins
pubmed
2481044
uniprot
proteins
pubmed
33894126
uniprot
proteins
pubmed
8294038
uniprot
proteins
sequence_length
1827
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:P20357}.
uniprot
proteins