RHOBTB3
entrez
22836
canonical
uniprot
O94955
canonical
ensembl
ENSG00000164292
resolver
ensp
ENSP00000369318
resolver
ensp
ENSP00000560147
resolver
enst
ENST00000379982
resolver
genesymbol
RHOBTB3
resolver
genesymbol_syn
KIAA0878
resolver
hgnc
HGNC:18757
resolver
uniprot
A0PJA4
resolver
uniprot
A8K1W9
resolver
uniprot
Q8IW06
resolver
uniprot_entry
RHBT3_HUMAN
resolver
uniprot_sec
A0PJA4
resolver
uniprot_sec
A8K1W9
resolver
uniprot_sec
Q8IW06
resolver
amino_acid_sequence
MSIHIVALGNEGDTFHQDNRPSGLIRTYLGRSPLVSGDESSLLLNAASTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKKRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNSDLNNLLFCCQCVDVVFYNPNLKKVVEAHKIVLCAVSHVFMLLFNVKSPTDIQDSSIIRTTQDLFAINRDTAFPGASHESSGNPPLRVIVKDALFCSCLSDILRFIYSGAFQWEELEEDIRKKLKDSGDVSNVIEKVKCILKTPGKINCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
function
FUNCTION: Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9. {ECO:0000269|PubMed:19490898}.
uniprot
proteins
mass_dalton
69413
uniprot
proteins
mutagenesis
MUTAGEN 138; /note="N->D: Abolishes ATP-binding."; /evidence="ECO:0000269|PubMed:19490898"; MUTAGEN 498; /note="A->T: Abolishes interaction with RAB9A."; /evidence="ECO:0000269|PubMed:19490898"; MUTAGEN 532; /note="D->E: Abolishes interaction with RAB9A."; /evidence="ECO:0000269|PubMed:19490898"; MUTAGEN 533; /note="I->K: Abolishes interaction with RAB9A."; /evidence="ECO:0000269|PubMed:19490898"; MUTAGEN 608..611; /note="Missing: Does not affect subcellular location, suggesting this protein is not prenylated."; /evidence="ECO:0000269|PubMed:19490898
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
12426103
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19490898
uniprot
proteins
sequence_length
611
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:19490898}.
uniprot
proteins