Stam
entrez
20844
canonical
uniprot
P70297
canonical
ensembl
ENSMUSG00000026718
resolver
ensp
ENSMUSP00000028050
resolver
ensp
ENSMUSP00000100025
resolver
ensp
ENSMUSP00000283821
resolver
enst
ENSMUST00000028050
resolver
enst
ENSMUST00000102960
resolver
genesymbol
Stam
resolver
genesymbol_syn
Stam1
resolver
uniprot
F6SJE8
resolver
uniprot
Q3TQ49
resolver
uniprot
Q3UGN9
resolver
uniprot_entry
F6SJE8_MOUSE
resolver
uniprot_entry
Q3TQ49_MOUSE
resolver
uniprot_entry
Q3UGN9_MOUSE
resolver
uniprot_entry
STAM1_MOUSE
resolver
amino_acid_sequence
MPLFATNPFDQDVEKATSELNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVATKKEEEDLAKAIELSLKEQRQQSAPVSTLYPSTSNLLTNHQHEGRKVRAVYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGVGLFPSNFVTADLTAEPEMIKTEKKTVQFNDDVQIETIEPEPEPAFIDEDKMDQLLQMLQSTDPSDNQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQSQQYYLQSSAVSASQVYPGPAQSGTYLVAGSAQMTHLQSYSLPPEQLSSISQGAVPSSANQALPSQQTQASYPNAMVSSVQGNSYPSQASIYSPPAAAAAAAAAAVVPVPVPADVTIYQNAGPTMSQVPNYTLTSSTLPQTGGSQQPPQPQQAYSQKALL
uniprot
proteins
function
FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
59771
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB (By similarity). {ECO:0000250|UniProtKB:Q92783}.; PTM: Ubiquitinated by ITCH. {ECO:0000250|UniProtKB:Q92783}.
uniprot
proteins
protein_family
STAM family
uniprot
proteins
pubmed
11340172
uniprot
proteins
pubmed
12446783
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19278655
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8780729
uniprot
proteins
sequence_length
548
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Early endosome membrane {ECO:0000250|UniProtKB:Q92783}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q92783}; Cytoplasmic side {ECO:0000250|UniProtKB:Q92783}.
uniprot
proteins