FREY1
entrez
143678
canonical
uniprot
C9JXX5
canonical
ensembl
ENSG00000234776
resolver
ensp
ENSP00000401498
resolver
enst
ENST00000449465
resolver
genesymbol
FREY1
resolver
genesymbol_syn
C11orf94
resolver
genesymbol_syn
FREY
resolver
hgnc
HGNC:37213
resolver
uniprot_entry
FREY_HUMAN
resolver
amino_acid_sequence
MVLAMLGALHPRAGLSLFLHLILAVALLRSQPLRSQRSVPEAFSAPLELSQPLSGLVDDYGILPKHPRPRGPRPLLSRAQQRKRDGPDLAEYYYDAHL
uniprot
proteins
function
FUNCTION: Key regulator for male fertility expressed transiently in round spermatids where it recruits IZUMO1 at the endoplasmic reticulum (ER) membrane and coordinates the oolemmal binding multimeric complex (IZUMO1 complex) assembly. Upon complete assembly of the IZUMO1 complex, its ER retention is released, facilitating IZUMO1 complex export to the acrosome. Through the interaction with SPPL2C, inhibits its intramembrane protease activity directly accessing the catalytic center of an I-CLiP. {ECO:0000250|UniProtKB:Q8CF31}.
uniprot
proteins
mass_dalton
10902
uniprot
proteins
pubmed
16554811
uniprot
proteins
sequence_length
98
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8CF31}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8CF31}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..29; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins