Cdk5rap1
entrez
66971
canonical
uniprot
Q8BTW8
canonical
ensembl
ENSMUSG00000027487
resolver
ensp
ENSMUSP00000028990
resolver
ensp
ENSMUSP00000105353
resolver
enst
ENSMUST00000028990
resolver
enst
ENSMUST00000109731
resolver
genesymbol
Cdk5rap1
resolver
uniprot
Q9D6Q4
resolver
uniprot_entry
CK5P1_MOUSE
resolver
uniprot_sec
Q9D6Q4
resolver
amino_acid_sequence
MHPLRCVLQVQRLSAPFTSMCWVLLRTCRAQSSVSSTPCPSPEAKSSEAQKDFSSRLATGPTFQHFLRSASVPQEKPSSPEVEDPPPYLSGDELLGRQRKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKVLKTKRPRSRVPLRIGILGCMAERLKGEILNREKMVDLLAGPDAYRDLPRLLAVVESGQQAANVLLSLDETYADIMPVQTSPSATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPVASILDEVRKLSEQGLKEVTLLGQNVNSFRDNSEVQFNNAGSANLSRGFTTNYKPKQGGLRFSHLLDQVSRIDPEMRIRFTSPHPKDFPDEVLQLIRERHNICKQIHLPAQSGSSRVLDAMRRGYSREAYVALVHHVRETIPGVSLSSDFITGFCGETEDDHRQTVSLLREVQYNTGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITVFREEASKANKTSVGCSQLVLVEGFSKRSTTDLCGRNDANLKVIFPDAEVEDITNPGLKVRAQPGDYVLVKITSASSQTLKGHILCRTTMKDSLTYCTT
uniprot
proteins
ec_number
2.8.4.3
uniprot
proteins
function
FUNCTION: Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:25738458). Essential for efficient and highly accurate protein translation by the ribosome (PubMed:25738458). Specifically inhibits CDK5 activation by CDK5R1 (By similarity). Essential for efficient mitochondrial protein synthesis and respiratory chain (PubMed:25738458). {ECO:0000250|UniProtKB:Q96SZ6, ECO:0000269|PubMed:25738458}.
uniprot
proteins
mass_dalton
66110
uniprot
proteins
protein_family
Methylthiotransferase family
uniprot
proteins
protein_family
MiaB subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
25738458
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25738458}.
uniprot
proteins