SUDS3
entrez
64426
canonical
uniprot
Q9H7L9
canonical
ensembl
ENSG00000111707
resolver
ensp
ENSP00000443988
resolver
ensp
ENSP00000692993
resolver
enst
ENST00000543473
resolver
genesymbol
SUDS3
resolver
genesymbol_syn
SAP45
resolver
genesymbol_syn
SDS3
resolver
hgnc
HGNC:29545
resolver
uniprot
Q4KMQ5
resolver
uniprot
Q8N6H0
resolver
uniprot
Q9H8D2
resolver
uniprot_entry
SDS3_HUMAN
resolver
uniprot_sec
Q4KMQ5
resolver
uniprot_sec
Q8N6H0
resolver
uniprot_sec
Q9H8D2
resolver
amino_acid_sequence
MSAAGLLAPAPAQAGAPPAPEYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSSPEHLPATPAESPAQRFEARIEDGKLYYDKRWYHKSQAIYLESKDNQKLSCVISSVGANEIWVRKTSDSTKMRIYLGQLQRGLFVIRRRSAA
uniprot
proteins
function
FUNCTION: Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:21239494}.
uniprot
proteins
mass_dalton
38136
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains. {ECO:0000269|PubMed:21239494}.
uniprot
proteins
protein_family
SDS3 family
uniprot
proteins
pubmed
11214971
uniprot
proteins
pubmed
12670868
uniprot
proteins
pubmed
12724404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21239494
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25805136
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21239494}.
uniprot
proteins