Hsph1
entrez
288444
canonical
uniprot
Q66HA8
canonical
ensembl
ENSRNOG00000000902
resolver
ensembl
ENSRNOG00055003922
resolver
ensembl
ENSRNOG00060002220
resolver
ensembl
ENSRNOG00065006176
resolver
ensp
ENSRNOP00000001201
resolver
ensp
ENSRNOP00000082622
resolver
ensp
ENSRNOP00055004765
resolver
ensp
ENSRNOP00060002370
resolver
ensp
ENSRNOP00065006758
resolver
enst
ENSRNOT00000001201
resolver
enst
ENSRNOT00000116960
resolver
enst
ENSRNOT00055006245
resolver
enst
ENSRNOT00060003473
resolver
enst
ENSRNOT00065009424
resolver
genesymbol
Hsph1
resolver
genesymbol_syn
Hsp105
resolver
genesymbol_syn
Hsp110
resolver
uniprot
A0A8I5ZXF4
resolver
uniprot_entry
A0A8I5ZXF4_RAT
resolver
uniprot_entry
HS105_RAT
resolver
amino_acid_sequence
MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGPKNRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGIKVMYMDEDHLFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNADEKPRVVVFVDMGHSSFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKDVSAKMNRSQFEELCAELLQKIEVPLHLLMEQTHLKTEEVSAIEIVGGATRIPAVKERIARFFGKDVSTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLVWNHDSEETEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQAVPYPEAKIGRFVVQNVSAQKDGEKSKVKVKVRVNTHGIFTISTASMVEKVPTEEEDGSSVEADMECPNQKPAESSDVDKNIQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLEKERNDAKNAVEECVYEFRDKLCGPYEKFICEQEHEKFLRLLTETEDWLYEEGEDQAKQAYIDKLEELMKMGTPVKVRFQEAEERPRVLEELGQRLQHYAKIAADFRGKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSLHQDPVVRTHEISAKVKELNNVCEPVVTQPKPKIESPKLERTPNGPNMDKKEDLEGKSNLGADAPHQNGECHPNEKGSVSMDLD
uniprot
proteins
function
FUNCTION: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. {ECO:0000250|UniProtKB:Q61699, ECO:0000250|UniProtKB:Q92598}.
uniprot
proteins
mass_dalton
96419
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity. {ECO:0000250|UniProtKB:Q61699}.
uniprot
proteins
protein_family
Heat shock protein 70 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
858
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q92598}.
uniprot
proteins