Prkag1
entrez
25520
canonical
uniprot
P80385
canonical
ensembl
ENSRNOG00000070180
resolver
ensembl
ENSRNOG00055029850
resolver
ensembl
ENSRNOG00060008684
resolver
ensembl
ENSRNOG00065019971
resolver
ensp
ENSRNOP00000070458
resolver
ensp
ENSRNOP00000091419
resolver
ensp
ENSRNOP00055042783
resolver
ensp
ENSRNOP00060011273
resolver
ensp
ENSRNOP00065027075
resolver
enst
ENSRNOT00000105867
resolver
enst
ENSRNOT00055051846
resolver
enst
ENSRNOT00060014618
resolver
enst
ENSRNOT00065033851
resolver
genesymbol
Prkag1
resolver
uniprot
Q4QQW6
resolver
uniprot_entry
AAKG1_RAT
resolver
uniprot_sec
Q4QQW6
resolver
amino_acid_sequence
MESVAAESAPAPENEHSQETPESNSSVYTTFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLEAIINRLVEAEVHRLVVVDEHDVVKGIVSLSDILQALVLTGGEKKP
uniprot
proteins
function
FUNCTION: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. {ECO:0000269|PubMed:17851531, ECO:0000269|PubMed:21399626}.
uniprot
proteins
mass_dalton
37386
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK. There is some ambiguity for a phosphosite: Ser-260/Thr-262. {ECO:0000269|PubMed:21460634}.; PTM: Glycosylated; O-GlcNAcylated by OGT, promoting the AMP-activated protein kinase (AMPK) activity. {ECO:0000250|UniProtKB:P54619}.
uniprot
proteins
protein_family
5'-AMP-activated protein kinase gamma subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17851531
uniprot
proteins
pubmed
21399626
uniprot
proteins
pubmed
21460634
uniprot
proteins
pubmed
22659875
uniprot
proteins
pubmed
25066137
uniprot
proteins
pubmed
7961907
uniprot
proteins
pubmed
8621499
uniprot
proteins
pubmed
8626596
uniprot
proteins
sequence_length
330
uniprot
proteins