Lrit3
entrez
242235
canonical
uniprot
W8DXL4
canonical
ensembl
ENSMUSG00000093865
resolver
ensp
ENSMUSP00000140184
resolver
enst
ENSMUST00000185462
resolver
genesymbol
Lrit3
resolver
uniprot_entry
LRIT3_MOUSE
resolver
amino_acid_sequence
MWLSACLCLVLSFLGGVNGTCPSQCSCEYHGRHDGSGSRLVLCNDLDMNEVPANFPVDTSKLRIEKTVVRRLPAEAFYYLVELQYLWLAYNSVASIETSSFYNLRQLHELRLDGNSLTAFPWVSLLDMPHLRTLDLHNNRIASVPNEAVRYLRNLTCLDLSSNRLTTLPPDFLDSWSHLAVTPSRSPDFPPRRIILGLQDNPWFCDCHISKVIELSKVTDHAVVLLDPLMVCSEPERFQGILFQRVELEKCLKPSVMMSATKITSALGSNVLLRCDAKGHPTPQLTWTRSDGSTVNYTVIQESPGEGIRWSIISLTSISHKDAGDYRCKAKNLAGISEAVVTVTVVGGVTTTLSPDSSERSPGEPPEQHPQPGLGGSTPPSKSWLSPGLTSAPSYPTPSAALYTSTWSPPPSSLPPIFSAASATTSVQTSISGRTARTSHQPPLLHPGGKSNAKIEKNGRKFPPLSASKKEELALLDQAAPMETNVTIKDLRVARETGVSVTLMWNSSSSTQESSVTVLYSKYGEKDLLLVNADDYGKNQATINGLEPGSQYVACVCPKGVGPREDLCITFSTNRVEGRGSQWSLLLVVTSTACVIVVPLICFLLYKVCKLQCTSDPFWEEDLSKETYIQFETLSPRSQSIGELWTRRHRDDGERLLLCSQSSVDSQMNLKSDGCRTEYYG
uniprot
proteins
function
FUNCTION: Plays a role in the synapse formation and synaptic transmission between cone photoreceptor cells and retinal bipolar cells (PubMed:25997951, PubMed:26427409, PubMed:28334377). Required for normal transmission of a light-evoked stimulus from the cone photoreceptor cells to the ON-bipolar cells and ON-ganglion cells in the inner retina (PubMed:26427409, PubMed:28334377). Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips (PubMed:25997951). Seems to play a specific role in synaptic contacts made by ON-bipolar cells with cone photoreceptor pedicles (PubMed:28334377). May also have a role in cone synapse formation (PubMed:25997951, PubMed:28334377). Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (By similarity). Could be a regulator of the FGFRs (By similarity). {ECO:0000250|UniProtKB:Q3SXY7, ECO:0000269|PubMed:25997951, ECO:0000269|PubMed:26427409, ECO:0000269|PubMed:28334377}.
uniprot
proteins
mass_dalton
74827
uniprot
proteins
mutagenesis
MUTAGEN 134; /note="L->P: Defects in depolarization of photoreceptors in the inner retina, and defects in cone photoreceptor light response. Gross morphology is normal."; /evidence="ECO:0000269|PubMed:26427409
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24598786
uniprot
proteins
pubmed
25997951
uniprot
proteins
pubmed
26427409
uniprot
proteins
pubmed
28334377
uniprot
proteins
sequence_length
681
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendrite {ECO:0000269|PubMed:25997951}. Perikaryon {ECO:0000269|PubMed:25997951}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q3SXY7}; Single-pass type I membrane protein {ECO:0000305}. Note=Punctate expression at dendrite tips. {ECO:0000269|PubMed:25997951}.
uniprot
proteins
transmembrane_region
TRANSMEM 585..605; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins