IFITM1
entrez
8519
canonical
uniprot
P13164
canonical
ensembl
ENSG00000185885
resolver
ensp
ENSP00000330825
resolver
ensp
ENSP00000386187
resolver
ensp
ENSP00000437057
resolver
ensp
ENSP00000505380
resolver
ensp
ENSP00000596460
resolver
enst
ENST00000328221
resolver
enst
ENST00000408968
resolver
enst
ENST00000528780
resolver
enst
ENST00000680588
resolver
enst
ENST00000926401
resolver
genesymbol
IFITM1
resolver
genesymbol_syn
CD225
resolver
genesymbol_syn
IFI17
resolver
hgnc
HGNC:5412
resolver
uniprot
Q15322
resolver
uniprot
Q53XZ0
resolver
uniprot_entry
IFM1_HUMAN
resolver
uniprot_sec
Q15322
resolver
uniprot_sec
Q53XZ0
resolver
amino_acid_sequence
MHKEEHEVAVLGPPPSTILPRSTVINIHSETSVPDHVVWSLFNTLFLNWCCLGFIAFAYSVKSRDRKMVGDVTGAQAYASTAKCLNIWALILGILMTIGFILLLVFGSVTVYHIMLQIIQEKRGY
uniprot
proteins
function
FUNCTION: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) (PubMed:26354436, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration (PubMed:33270927). Inhibits SARS-CoV-2 S protein-mediated syncytia formation (PubMed:33051876). Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). {ECO:0000269|PubMed:16847454, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20838853, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:22634173, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:33270927}.
uniprot
proteins
mass_dalton
13964
uniprot
proteins
mutagenesis
MUTAGEN 50..51; /note="CC->AA: No effect on anti-HCV activity. Only localizes at the lysosome."; /evidence="ECO:0000269|PubMed:26354436"; MUTAGEN 84; /note="C->A: Loss of anti-HCV activity. Only localizes at the lysosome."; /evidence="ECO:0000269|PubMed:26354436
uniprot
proteins
post_translational_modification
PTM: Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity. {ECO:0000305|PubMed:26354436}.
uniprot
proteins
protein_family
CD225/Dispanin family
uniprot
proteins
pubmed
1383329
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16847454
uniprot
proteins
pubmed
19499152
uniprot
proteins
pubmed
20064371
uniprot
proteins
pubmed
20838853
uniprot
proteins
pubmed
21166591
uniprot
proteins
pubmed
21177806
uniprot
proteins
pubmed
21253575
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21976647
uniprot
proteins
pubmed
22363774
uniprot
proteins
pubmed
22479637
uniprot
proteins
pubmed
22634173
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2398277
uniprot
proteins
pubmed
2492664
uniprot
proteins
pubmed
25105503
uniprot
proteins
pubmed
26354436
uniprot
proteins
pubmed
33051876
uniprot
proteins
pubmed
33270927
uniprot
proteins
pubmed
33522642
uniprot
proteins
pubmed
7559564
uniprot
proteins
sequence_length
125
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1383329, ECO:0000269|PubMed:19499152, ECO:0000269|PubMed:25105503, ECO:0000269|PubMed:26354436}; Single-pass membrane protein {ECO:0000269|PubMed:19499152}. Lysosome membrane {ECO:0000269|PubMed:26354436}.
uniprot
proteins
transmembrane_region
TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins