Plk4
entrez
20873
canonical
uniprot
Q64702
canonical
ensembl
ENSMUSG00000025758
resolver
ensp
ENSMUSP00000026858
resolver
ensp
ENSMUSP00000145277
resolver
ensp
ENSMUSP00000163674
resolver
genesymbol
Plk4
resolver
genesymbol_syn
Sak
resolver
genesymbol_syn
Stk18
resolver
uniprot
Q3UVA3
resolver
uniprot
Q6PEP6
resolver
uniprot
Q78EG6
resolver
uniprot
Q80UT6
resolver
uniprot
Q8R0I5
resolver
uniprot
Q9CVR6
resolver
uniprot
Q9CVU6
resolver
uniprot_entry
PLK4_MOUSE
resolver
uniprot_sec
Q3UVA3
resolver
uniprot_sec
Q6PEP6
resolver
uniprot_sec
Q78EG6
resolver
uniprot_sec
Q80UT6
resolver
uniprot_sec
Q8R0I5
resolver
uniprot_sec
Q9CVR6
resolver
uniprot_sec
Q9CVU6
resolver
amino_acid_sequence
MAACIGERIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLHSHGILHRDLTLSNILLTRNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFMSRNPSPKSKDVGTVEDSMDSGHATLSTTITASSGTSLSGSLLDRRLLVGQPLPNKITVFQKNKNSSDFSSGDGSNFCTQWGNPEQEANSRGRGRVIEDAEERPHSRYLRRAHSSDRASPSNQSRAKTYSVERCHSVEMLSKPRRSLDENQHSSNHHCLGKTPFPFADQTPQMEMVQQWFGNLQMNAHLGETNEHHTVSPNRDFQDYPDLQDTLRNAWTDTRASKNADTSANVHAVKQLSAMKYMSAHHHKPEVMPQEPGLHPHSEQSKNRSMESTLGYQKPTLRSITSPLIAHRLKPIRQKTKKAVVSILDSEEVCVELLRECASEGYVKEVLQISSDGTMITVYYPNDGRGFPLADRPPLPTDNISRYSFDNLPEKYWRKYQYASRFIQLVRSKTPKITYFTRYAKCILMENSPGADFEVWFYDGAKIHKTENLIHIIEKTGISYNLKNENEVTSLKEEVKVYMDHANEGHRICLSLESVISEEEKRSRGSSFFPIIVGRKPGNTSSPKALSAPPVDPSCCKGEQASASRLSVNSAAFPTQSPGLSPSTVTVEGLGHTATATGTGVSSSLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSSISYTSPDGQTTRYGENEKLPEYIKQKLQCLSSILLMFSNPTPNFQ
uniprot
proteins
ec_number
2.7.11.21
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Phosphorylates CDC25C and CHEK2. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (By similarity). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (By similarity). {ECO:0000250|UniProtKB:O00444, ECO:0000269|PubMed:17891141, ECO:0000269|PubMed:24240477}.
uniprot
proteins
mass_dalton
103746
uniprot
proteins
mutagenesis
MUTAGEN 170; /note="T->D: Activating mutant."; /evidence="ECO:0000269|PubMed:17891141
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; leading to its degradation by the proteasome (PubMed:8756623). Deubiquitinated by USP54; leading to PLK4 stabilization (By similarity). {ECO:0000250|UniProtKB:O00444, ECO:0000269|PubMed:8756623}.; PTM: Tyrosine-phosphorylated by TEC. {ECO:0000250}.; PTM: Acetylation by KAT2A and KAT2B impairs kinase activity by shifting the kinase to an inactive conformation. {ECO:0000250|UniProtKB:O00444}.
uniprot
proteins
protein_family
CDC5/Polo subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
11301255
uniprot
proteins
pubmed
12352953
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16025114
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17891141
uniprot
proteins
pubmed
24240477
uniprot
proteins
pubmed
8022793
uniprot
proteins
pubmed
8756623
uniprot
proteins
sequence_length
925
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:11301255}. Nucleus, nucleolus {ECO:0000269|PubMed:11301255}. Cleavage furrow {ECO:0000269|PubMed:11301255}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O00444}. Note=Associates with centrioles throughout the cell cycle. According to PubMed:11301255, it localizes to the nucleolus during G2, to the centrosomes in G2/M, and to the cleavage furrow during cytokinesis. Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles.
uniprot
proteins