Htr1d
entrez
15552
canonical
uniprot
Q61224
canonical
ensembl
ENSMUSG00000070687
resolver
ensp
ENSMUSP00000086052
resolver
ensp
ENSMUSP00000112402
resolver
ensp
ENSMUSP00000112840
resolver
ensp
ENSMUSP00000199094
resolver
ensp
ENSMUSP00000199095
resolver
ensp
ENSMUSP00000199096
resolver
enst
ENSMUST00000088677
resolver
enst
ENSMUST00000117699
resolver
enst
ENSMUST00000121571
resolver
genesymbol
Htr1d
resolver
genesymbol_syn
Gpcr14
resolver
uniprot
Q3ZB48
resolver
uniprot
Q61615
resolver
uniprot
Q8BUW7
resolver
uniprot_entry
5HT1D_MOUSE
resolver
uniprot_sec
Q3ZB48
resolver
uniprot_sec
Q61615
resolver
uniprot_sec
Q8BUW7
resolver
amino_acid_sequence
MSPPNQSLEGLPQEASNRSLNVTGAWDPEVLQALRISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQKVVHFRKIS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. {ECO:0000250|UniProtKB:P28221}.
uniprot
proteins
mass_dalton
41594
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22273508
uniprot
proteins
pubmed
8288218
uniprot
proteins
pubmed
8978753
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P28221}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P28221}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..61; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P28221"; TRANSMEM 73..94; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P28221"; TRANSMEM 107..131; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P28221"; TRANSMEM 152..173; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P28221"; TRANSMEM 192..215; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P28221"; TRANSMEM 298..323; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P28221"; TRANSMEM 333..356; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P28221
uniprot
proteins