Pde9a
entrez
18585
canonical
uniprot
O70628
canonical
ensembl
ENSMUSG00000041119
resolver
ensp
ENSMUSP00000038005
resolver
ensp
ENSMUSP00000116724
resolver
ensp
ENSMUSP00000117611
resolver
ensp
ENSMUSP00000157420
resolver
ensp
ENSMUSP00000248770
resolver
ensp
ENSMUSP00000248777
resolver
enst
ENSMUST00000047168
resolver
enst
ENSMUST00000127929
resolver
enst
ENSMUST00000136384
resolver
enst
ENSMUST00000236454
resolver
genesymbol
Pde9a
resolver
genesymbol_syn
Pde8b
resolver
uniprot
D3Z408
resolver
uniprot
Q8BSU4
resolver
uniprot_entry
D3Z408_MOUSE
resolver
uniprot_entry
PDE9A_MOUSE
resolver
uniprot_entry
Q8BSU4_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by SCH 51866 and moderately, by zaprinast. Specifically inhibited by PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) (PubMed:22328573). {ECO:0000269|PubMed:22328573, ECO:0000269|PubMed:9624145}.
uniprot
proteins
amino_acid_sequence
MGAGSSSYRPKAIYLDIDGRIQKVVFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAVKQVSEREELIQGVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARNSRTNCPCKYSFLDNKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPITLRRWLLCVHDNYRNNPFHNFRHCFCVTQMMYSMVWLCGLQEKFSQMDILVLMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAIAFQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHLTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPVVEETMLRPLWESREHYEELKQLDDAMKELQKKTESLTSGAPENTTEKNRDAKDSEGHSPPN
uniprot
proteins
ec_number
3.1.4.35
uniprot
proteins
function
FUNCTION: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes (PubMed:9624145). Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (PubMed:22328573, PubMed:24746365). {ECO:0000269|PubMed:22328573, ECO:0000269|PubMed:24746365, ECO:0000269|PubMed:25799991, ECO:0000269|PubMed:9624145, ECO:0000305}.
uniprot
proteins
mass_dalton
61636
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE9 subfamily
uniprot
proteins
pubmed
14501210
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22328573
uniprot
proteins
pubmed
24746365
uniprot
proteins
pubmed
25799991
uniprot
proteins
pubmed
9624145
uniprot
proteins
pubmed
9856478
uniprot
proteins
sequence_length
534
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O76083}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O76083}. Golgi apparatus {ECO:0000250|UniProtKB:O76083}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O76083}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:O76083}.
uniprot
proteins