Ank
entrez
11732
canonical
uniprot
Q9JHZ2
canonical
ensembl
ENSMUSG00000022265
resolver
ensp
ENSMUSP00000022875
resolver
enst
ENSMUST00000022875
resolver
genesymbol
Ank
resolver
genesymbol
Ankh
resolver
genesymbol_syn
Ank
resolver
uniprot
O35138
resolver
uniprot
O35139
resolver
uniprot
Q3UG85
resolver
uniprot
Q8C438
resolver
uniprot_entry
ANKH_MOUSE
resolver
uniprot_entry
Q3UG85_MOUSE
resolver
uniprot_entry
Q8C438_MOUSE
resolver
uniprot_sec
O35138
resolver
uniprot_sec
O35139
resolver
amino_acid_sequence
MVKFPALTHYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSKRDRAKAVLCMVVAGAIAAVFHTLIAYSDLGYYIINKLHHVDESVGSKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFLVGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCLGYYRNIHDIIPDRSGPELGGDATIRKMLSFWWPLALILATQRISRPIVNLFVSRDLGGSSAATEAVAILTATYPVGHMPYGWLTEIRAVYPAFDKNNPSNKLANTSNTVTSAHIKKFTFVCMALSLTLCFVMFWTPNVSEKILIDIIGVDFAFAELCVIPLRIFSFFPVPVTVRAHLTGWLMTLKKTFVLAPSSVLRIIVLITSLVVLPYLGVHGATLGVGSLLAGFVGESTMVALAACYVYRKQKKKMENESATEGEDSAMTDMPPTEEVTDIVEMREENE
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Ankh are the cause of a generalized, progressive form of arthritis. In ank mice hydroxyapatite crystals develop in articular surfaces and synovial fluid leading to joint space narrowing, cartilage erosion, and formation of bony outgrowths or osteophytes that cause fusion and joint immobility and destruction.
uniprot
proteins
function
FUNCTION: Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1. Regulates the release of the TCA cycle intermediates to the extracellular space, in particular citrate, succinate and malate. Extracellular citrate mostly present in bone tissue is required for osteogenic differentiation of mesenchymal stem cells, stabilization of hydroxyapatite structure and overall bone strength. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q9HCJ1, ECO:0000269|PubMed:32639996}.
uniprot
proteins
mass_dalton
54298
uniprot
proteins
protein_family
ANKH family
uniprot
proteins
pubmed
10894769
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20943778
uniprot
proteins
pubmed
32639996
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9HCJ1}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 86..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 132..152; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 159..179; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 327..347; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 351..371; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 404..426; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 430..452; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins