Hpse
entrez
15442
canonical
uniprot
Q6YGZ1
canonical
ensembl
ENSMUSG00000035273
resolver
ensp
ENSMUSP00000044072
resolver
enst
ENSMUST00000045617
resolver
genesymbol
Hpse
resolver
genesymbol_syn
Hpa
resolver
uniprot
B2RS99
resolver
uniprot
Q8K3K3
resolver
uniprot_entry
HPSE_MOUSE
resolver
uniprot_sec
B2RS99
resolver
uniprot_sec
Q8K3K3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by EDTA and activated by calcium and magnesium (By similarity). Inhibited by laminarin sulfate and, to a lower extent, by heparin and sulfamin. {ECO:0000250, ECO:0000269|PubMed:12460766, ECO:0000269|PubMed:12837765}.
uniprot
proteins
amino_acid_sequence
MLRLLLLWLWGPLGALAQGAPAGTAPTDDVVDLEFYTKRPLRSVSPSFLSITIDASLATDPRFLTFLGSPRLRALARGLSPAYLRFGGTKTDFLIFDPDKEPTSEERSYWKSQVNHDICRSEPVSAAVLRKLQVEWPFQELLLLREQYQKEFKNSTYSRSSVDMLYSFAKCSGLDLIFGLNALLRTPDLRWNSSNAQLLLDYCSSKGYNISWELGNEPNSFWKKAHILIDGLQLGEDFVELHKLLQRSAFQNAKLYGPDIGQPRGKTVKLLRSFLKAGGEVIDSLTWHHYYLNGRIATKEDFLSSDVLDTFILSVQKILKVTKEITPGKKVWLGETSSAYGGGAPLLSNTFAAGFMWLDKLGLSAQMGIEVVMRQVFFGAGNYHLVDENFEPLPDYWLSLLFKKLVGPRVLLSRVKGPDRSKLRVYLHCTNVYHPRYQEGDLTLYVLNLHNVTKHLKVPPPLFRKPVDTYLLKPSGPDGLLSKSVQLNGQILKMVDEQTLPALTEKPLPAGSALSLPAFSYGFFVIRNAKIAACI
uniprot
proteins
ec_number
3.2.1.166
uniprot
proteins
function
FUNCTION: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as a procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis. {ECO:0000269|PubMed:15677344, ECO:0000269|PubMed:15793281, ECO:0000269|PubMed:17689495, ECO:0000269|PubMed:18589009}.
uniprot
proteins
mass_dalton
60066
uniprot
proteins
post_translational_modification
PTM: Proteolytically processed. The cleavage of the 65 kDa form leads to the generation of a linker peptide, and the 8 kDa and 50 kDa products. The active form, the 8/50 kDa heterodimer, is resistant to degradation. Complete removal of the linker peptide appears to be a prerequisite to the complete activation of the enzyme (By similarity). {ECO:0000250}.; PTM: N-glycosylated. Glycosylation of the 50 kDa subunit appears to be essential for its solubility. {ECO:0000269|PubMed:12460766}.
uniprot
proteins
protein_family
Glycosyl hydrolase 79 family
uniprot
proteins
pubmed
10395326
uniprot
proteins
pubmed
12460766
uniprot
proteins
pubmed
12837765
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15677344
uniprot
proteins
pubmed
15793281
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17689495
uniprot
proteins
pubmed
18589009
uniprot
proteins
sequence_length
535
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000269|PubMed:15793281}. Nucleus {ECO:0000269|PubMed:15793281}. Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity). Associates with lipid rafts. {ECO:0000250}.
uniprot
proteins