Ints7
entrez
77065
canonical
uniprot
Q7TQK1
canonical
ensembl
ENSMUSG00000037461
resolver
ensp
ENSMUSP00000036277
resolver
enst
ENSMUST00000045450
resolver
genesymbol
Ints7
resolver
uniprot
A0A0R4J0E4
resolver
uniprot
Q8C3A9
resolver
uniprot
Q8C3N4
resolver
uniprot
Q8C3N6
resolver
uniprot_entry
A0A0R4J0E4_MOUSE
resolver
uniprot_entry
INT7_MOUSE
resolver
uniprot_sec
Q8C3A9
resolver
uniprot_sec
Q8C3N4
resolver
uniprot_sec
Q8C3N6
resolver
amino_acid_sequence
MASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPILINSAFLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRVFSVIHSNDPVARAITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSKDFAVGICNKISEMIQGLATPVDLKLKLIPILQHMHHDALLASSARQLLQQLVTSYPSTKMVIVSLHTFTLLAASSLVDTPKQIQLLLQYLKNDPRKAVKRLAVQDLKLLASKTPHTWSKENIQALCECALHTPYDSLKLGMLSVLSTLSGTIAIKHYFSVVPGNVGSSPRSSDLVKLAQECCYHSNRGIAAHGVRVLTNITVSCQEKDLLSLEQDAVFGLESLLVLCSQDDSPGAQSTVKSALSCMVKLAKGRPHLSRSVVDTLLTQLHSSQDAARILMCHCLAAIAMQLPVLGDGMLGDLVELYKVIGRSATDKQQELLVSLATVIFVASQKALSAEVKAVIKQQLESVSSGWTVYRIARQASRMGNHDMARELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEDSFSSALSCIAESLKFYHKGIASLTAASTPLNPLSFQCEFVKLRIDLLQAFSQLICTCNSLKTSPPPAIATTIAMTLGNDLQRCGRISNQMKQSMEEFRSLASRYRDLYQASFDADSATLRNVELQQQSCLLIAHAIEALVLDPESASFQEYGSTGAAHADSEYERRMMSVYSRVLEEVESLNRKYAPVSYMHTACLCNAIIALLKVPLSFQRYFFQKLQSTSIKLALSPSPRSPAEPIAVQNNQQLALKVEGVVQHGSKPGLFRRVQSVCLNVSSTLQSKSGQDYKIPIDSMTNEMEQRVEPHNDYFSTQFLLNFAVLGTHSITVESSVRDANGIVWKTGPRTTMFVKSLEDPYSQQIRLQQQAQQPLQPQPLPQPQPRSAYTRF
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex. Plays a role in DNA damage response (DDR) signaling during the S phase. {ECO:0000250|UniProtKB:Q9NVH2}.
uniprot
proteins
mass_dalton
106861
uniprot
proteins
protein_family
Integrator subunit 7 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
966
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NVH2}. Chromosome {ECO:0000250|UniProtKB:Q9NVH2}. Cytoplasm {ECO:0000250|UniProtKB:Q9NVH2}. Note=Localizes to sites of DNA damage in a H2AX-independent manner. {ECO:0000250|UniProtKB:Q9NVH2}.
uniprot
proteins