F5H094
uniprot
F5H094
canonical
activity_regulation
ACTIVITY REGULATION: Transport activity is induced by farnesoid X receptor (FXR) agonists such as chenodeoxycholate. {ECO:0000269|PubMed:31509437}.
uniprot
proteins
amino_acid_sequence
MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMGYYRYSKETNIDPSENSTSNLPNCLINQMLSLNRTPSEIIERGCVKESGSHMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGTVNVMGMTGLVFAFMLGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGIVSIISSIPFFFLPLNPNKPQKERKVSLFLHVLKTNDKRNQIANLTNRRKYITKNVTGFFQSLKSILTNPLYVIFVIFTLLHMSSYIASLTYIIKMVEQQYGWSASKTNFLLGVLALPAVAIGMFSGGYIIKKFKLSLVGLAKLAFCSATVHLLSQVLYFFLICESKSVAGLTLTYDGNSPVRSHVDVPLSYCNSECNCDESQWEPVCGNNGITYLSPCLAGCKSSSGNKEPIVFYNCSCVEVIGLQNKNYSAHLGECPRDDACTRKSYVYFVIQVLDAFLCAVGLTSYSVLVIRIVQPELKALAIGFHSMIMRSLGGILVPIYFGALIDTTCMKWSTNSCGARGACRIYNSTYLGRAFFGLKVALIFPVLVLLTVFIFVVRKKSHGKDTKVLENERQVMDEANLEFLNDSEHFVPSAEEQ
uniprot
proteins
function
FUNCTION: Mediates the Na(+)-independent uptake of organic anions (PubMed:29248594). Transports the conjugated steroids 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate) or E2G) and dehydroepiandrosterone 3-sulfate (DHEAS) at the smooth endoplasmic reticulum membrane (SER), granting access to metabolizing enzymes (PubMed:29248594, PubMed:31127008, PubMed:32818652). Contributes to the metabolism of bile acids such as taurocholate (cholyltaurine) and lithocholate, by functioning as a doorway between SER and cytosol, thereby decreasing their circulating levels and protecting the organism from their detergent properties (PubMed:31509437). Regulates access or exit of drugs to the SER lumen (PubMed:31127008). {ECO:0000269|PubMed:29248594, ECO:0000269|PubMed:31127008, ECO:0000269|PubMed:31509437, ECO:0000269|PubMed:32818652}.
uniprot
proteins
mass_dalton
76346
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
29248594
uniprot
proteins
pubmed
31127008
uniprot
proteins
pubmed
31509437
uniprot
proteins
pubmed
32818652
uniprot
proteins
sequence_length
687
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Smooth endoplasmic reticulum membrane {ECO:0000269|PubMed:29248594}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU362056}. Cell membrane {ECO:0000269|PubMed:29248594, ECO:0000269|PubMed:32818652}; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:29248594}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 64..84; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 97..117; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 171..191; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 259..279; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 340..360; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 410..430; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 540..560; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 569..589; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 625..645; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins