TDG
entrez
6996
canonical
uniprot
Q13569
canonical
ensembl
ENSG00000139372
resolver
ensp
ENSP00000266775
resolver
ensp
ENSP00000376611
resolver
ensp
ENSP00000445899
resolver
enst
ENST00000266775
resolver
enst
ENST00000392872
resolver
enst
ENST00000544861
resolver
genesymbol
TDG
resolver
hgnc
HGNC:11700
resolver
uniprot
B4DI29
resolver
uniprot
B4E127
resolver
uniprot
F6RAW1
resolver
uniprot
G8JL98
resolver
uniprot
Q8IUZ6
resolver
uniprot
Q8IZM3
resolver
uniprot_entry
B4DI29_HUMAN
resolver
uniprot_entry
B4E127_HUMAN
resolver
uniprot_entry
F6RAW1_HUMAN
resolver
uniprot_entry
G8JL98_HUMAN
resolver
uniprot_entry
TDG_HUMAN
resolver
uniprot_sec
Q8IUZ6
resolver
uniprot_sec
Q8IZM3
resolver
amino_acid_sequence
MEAENAGSYSLQQAQAFYTFPFQQLMAEAPNMAVVNEQQMPEEVPAPAPAQEPVQEAPKGRKRKPRTTEPKQPVEPKKPVESKKSGKSAKSKEKQEKITDTFKVKRKVDRFNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIERNMDVQEVQYTFDLQLAQEDAKKMAVKEEKYDPGYEAAYGGAYGENPCSSEPCGFSSNGLIESVELRGESAFSGIPNGQWMTQSFTDQIPSFSNHCGTQEQEEESHA
uniprot
proteins
ec_number
3.2.2.29
uniprot
proteins
function
FUNCTION: DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. {ECO:0000269|PubMed:21862836, ECO:0000269|PubMed:22327402, ECO:0000269|PubMed:22573813, ECO:0000269|PubMed:22962365, ECO:0000269|PubMed:8127859, ECO:0000269|PubMed:8407958, ECO:0000269|PubMed:8662714}.
uniprot
proteins
mass_dalton
46053
uniprot
proteins
mutagenesis
MUTAGEN 140; /note="N->A: Loss of DNA glycosylase activity but still able to bind DNA."; /evidence="ECO:0000269|PubMed:22327402"; MUTAGEN 145; /note="A->G: Increased DNA glycosylase activity on G/T mispairs."; /evidence="ECO:0000269|PubMed:22573813"; MUTAGEN 151; /note="H->A,Q: Increased DNA glycosylase activity on G/T mispairs."; /evidence="ECO:0000269|PubMed:22573813"; MUTAGEN 191; /note="N->A: Reduced DNA glycosylase activity on G/T and G/U mispairs."; /evidence="ECO:0000269|PubMed:22573813"; MUTAGEN 197; /note="T->A: Reduced DNA glycosylase activity on G/T mispairs."; /evidence="ECO:0000269|PubMed:22573813"; MUTAGEN 281; /note="R->A: Restores the DNA-binding ability of the sumoylated form."; /evidence="ECO:0000269|PubMed:15959518"; MUTAGEN 310; /note="E->Q: Restores the DNA-binding ability of the sumoylated form."; /evidence="ECO:0000269|PubMed:15959518, ECO:0000269|PubMed:16626738"; MUTAGEN 315; /note="F->A: Restores the DNA-binding ability of the sumoylated form."; /evidence="ECO:0000269|PubMed:15959518
uniprot
proteins
post_translational_modification
PTM: Sumoylation on Lys-330 by either SUMO1 or SUMO2 induces dissociation of the product DNA. {ECO:0000269|PubMed:11889051}.
uniprot
proteins
protein_family
TDG/mug family
uniprot
proteins
protein_family
Uracil-DNA glycosylase (UDG) superfamily
uniprot
proteins
pubmed
11889051
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15959518
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16626738
uniprot
proteins
pubmed
18587051
uniprot
proteins
pubmed
21722948
uniprot
proteins
pubmed
21862836
uniprot
proteins
pubmed
22327402
uniprot
proteins
pubmed
22573813
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22962365
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
8127859
uniprot
proteins
pubmed
8407958
uniprot
proteins
pubmed
8662714
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8662714}.
uniprot
proteins