Entpd5
entrez
12499
canonical
uniprot
Q9WUZ9
canonical
ensembl
ENSMUSG00000021236
resolver
ensp
ENSMUSP00000021662
resolver
ensp
ENSMUSP00000071939
resolver
ensp
ENSMUSP00000105901
resolver
ensp
ENSMUSP00000112516
resolver
ensp
ENSMUSP00000113106
resolver
ensp
ENSMUSP00000114011
resolver
ensp
ENSMUSP00000168094
resolver
ensp
ENSMUSP00000168106
resolver
enst
ENSMUST00000021662
resolver
enst
ENSMUST00000072061
resolver
enst
ENSMUST00000110272
resolver
enst
ENSMUST00000117286
resolver
enst
ENSMUST00000120942
resolver
enst
ENSMUST00000122194
resolver
genesymbol
Entpd5
resolver
genesymbol_syn
Cd39l4
resolver
uniprot
F8WGZ2
resolver
uniprot
O70214
resolver
uniprot
Q3TQC7
resolver
uniprot
Q544J4
resolver
uniprot
Q8BR23
resolver
uniprot
Q8CD29
resolver
uniprot_entry
ENTP5_MOUSE
resolver
uniprot_entry
F8WGZ2_MOUSE
resolver
uniprot_entry
Q3TQC7_MOUSE
resolver
uniprot_sec
O70214
resolver
uniprot_sec
Q544J4
resolver
uniprot_sec
Q8BR23
resolver
uniprot_sec
Q8CD29
resolver
amino_acid_sequence
MATSWGAVFMLIIACVGSTVFYREQQTWFEGVFLSSMCPINVSAGTFYGIMFDAGSTGTRIHVYTFVQKTAGQLPFLEGEIFDSVKPGLSAFVDQPKQGAETVQELLEVAKDSIPRSHWERTPVVLKATAGLRLLPEQKAQALLLEVEEIFKNSPFLVPDGSVSIMDGSYEGILAWVTVNFLTGQLHGRGQETVGTLDLGGASTQITFLPQFEKTLEQTPRGYLTSFEMFNSTFKLYTHSYLGFGLKAARLATLGALEAKGTDGHTFRSACLPRWLEAEWIFGGVKYQYGGNQEGEMGFEPCYAEVLRVVQGKLHQPEEVRGSAFYAFSYYYDRAADTHLIDYEKGGVLKVEDFERKAREVCDNLGSFSSGSPFLCMDLTYITALLKDGFGFADGTLLQLTKKVNNIETGWALGATFHLLQSLGITS
uniprot
proteins
ec_number
3.6.1.6
uniprot
proteins
function
FUNCTION: Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (PubMed:10369669, PubMed:21074248). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose (PubMed:21074248). Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose (PubMed:21074248). Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (PubMed:21074248). {ECO:0000269|PubMed:10369669, ECO:0000269|PubMed:21074248}.
uniprot
proteins
mass_dalton
47102
uniprot
proteins
mutagenesis
MUTAGEN 171; /note="E->A: Loss of nucleoside-diphosphatase activity."; /evidence="ECO:0000305|PubMed:21074248
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000305|PubMed:21074248}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; high-mannose type. {ECO:0000269|PubMed:10369669, ECO:0000269|PubMed:21074248}.
uniprot
proteins
protein_family
GDA1/CD39 NTPase family
uniprot
proteins
pubmed
10369669
uniprot
proteins
pubmed
10506756
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19176496
uniprot
proteins
pubmed
21074248
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9457681
uniprot
proteins
sequence_length
427
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:10369669}. Secreted {ECO:0000250|UniProtKB:O75356}.
uniprot
proteins