Cfap53
entrez
74453
canonical
uniprot
Q9D439
canonical
ensembl
ENSMUSG00000035394
resolver
ensp
ENSMUSP00000110545
resolver
genesymbol
Cfap53
resolver
genesymbol_syn
Ccdc11
resolver
uniprot
Q059Q0
resolver
uniprot
Q4KL15
resolver
uniprot_entry
CFA53_MOUSE
resolver
uniprot_entry
Q059Q0_MOUSE
resolver
uniprot_sec
Q4KL15
resolver
amino_acid_sequence
MYSQQFGTVPREFKGPTPKAVIIRAKPPKAQRAEQHLKRIQRSYHKYHTTLASIKSNEENRLKCDWIQRNNHKTFDSLVQARVQDAMQGFVINTEERRNKLRELLASEENEYFSEMQLKGETIEEKKDKMRERTKLLREKKEKERQEFVAEKLDQQFRERCEELRTKLASIHEKKVVEERNAQIEFNKELKRQKLVEEHLFARLWEEDRLAKERREAQEEKRQRELVQNTRLGLDAQVTSIQAQRQGARRMKEEEARILEQNKAQIKREDEQEKLQKQKRRQETRSSLKKAVQDKIESMQREYREDLDLNMKLVGRALQDLQDEADKKKQKREEMGREQKIYNDYLMQRREEEKAQEKELNRLLEDIKAKKLAEKDRELALQRAARKQLMNEVMNTRKLQVQERLQRKLREQEELALHEQRISESLKVLHQEDMEDFARRCALAEEYRNQLQMQIAHQQQAREAEKEEERQEFEAGLAANKACLDKIQRILSENQALSQNVHPMRRGYPDKPPL
uniprot
proteins
function
FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:37295417, PubMed:37865089, PubMed:37989994). Regulates motility patterns of both 9+0 and 9+2 motile cilia through differential localization and recruitment of axonemal dynein components (PubMed:33347437). Required for centriolar satellite integrity and non-motile cilium assembly (By similarity). Required for motile cilium formation (By similarity). Through its role in the beating of primary cilia, involved in the establishment of organ laterality during embryogenesis (PubMed:33347437). Required for sperm flagellum biogenesis and is essential for male fertility (PubMed:34124066). {ECO:0000250|UniProtKB:F1N7G5, ECO:0000250|UniProtKB:Q96M91, ECO:0000269|PubMed:33347437, ECO:0000269|PubMed:34124066, ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37865089, ECO:0000269|PubMed:37989994}.
uniprot
proteins
mass_dalton
61911
uniprot
proteins
protein_family
CFAP53 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
33347437
uniprot
proteins
pubmed
34124066
uniprot
proteins
pubmed
35587122
uniprot
proteins
pubmed
37295417
uniprot
proteins
pubmed
37865089
uniprot
proteins
pubmed
37989994
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:33347437}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:34124066, ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37865089, ECO:0000269|PubMed:37989994}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:33347437}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q96M91}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:33347437, ECO:0000269|PubMed:34124066}. Note=In tracheal cell cilia, localizes prominently to both centriolar satellites and axonemes (PubMed:33347437). Tightly associated with microtubules in tracheal cilia (PubMed:33347437). In embryonic node cells, localizes to the base of the node cilia at the centriolar satellites and, to a lesser extent, to the cilium axoneme (PubMed:33347437). Localizes to centriolar satellites through G1, S phase, G2 and mitosis (By similarity). Enriched on the spindle poles in mitosis (By similarity). Relocalizes from the centriolar satellite to the ciliary transition zone upon ciliogenesis (By similarity). In skin fibroblast cells, locates predominantly to the centriole with much lower levels associated with the actin cytoskeleton (By similarity). Localizes to the sperm flagellum and manchette (PubMed:34124066). {ECO:0000250|UniProtKB:Q96M91, ECO:0000269|PubMed:33347437, ECO:0000269|PubMed:34124066}.
uniprot
proteins