Catsper3
entrez
76856
canonical
uniprot
Q80W99
canonical
ensembl
ENSMUSG00000021499
resolver
ensp
ENSMUSP00000021961
resolver
ensp
ENSMUSP00000105524
resolver
ensp
ENSMUSP00000359244
resolver
genesymbol
Catsper3
resolver
uniprot
E0Z0E0
resolver
uniprot
E0Z0E1
resolver
uniprot
Q5FWA9
resolver
uniprot
Q9D5T9
resolver
uniprot_entry
CTSR3_MOUSE
resolver
uniprot_entry
E0Z0E0_MOUSE
resolver
uniprot_entry
E0Z0E1_MOUSE
resolver
uniprot_sec
Q5FWA9
resolver
uniprot_sec
Q9D5T9
resolver
activity_regulation
ACTIVITY REGULATION: In contrast to the human ortholog, not activated by progesterone (PubMed:21412339). Activated by intracellular alkalinization (By similarity). {ECO:0000250|UniProtKB:Q86XQ3, ECO:0000269|PubMed:21412339}.
uniprot
proteins
amino_acid_sequence
MSQHFHHNPVRVKSGSLFATASEALQARLSKIKRKDKECQAYFRKVIKSTFFQIVMITTVTTNSFLLVLGTNYDIQFEFFRTFEVSELFFVSVYVCEFLMKVYVDPITYWKDGYNILDVIILIILTIPYLLRKIKGNHSAYLHFADGIQSLRILKLISYSRGIRTLIIAVGETVYTVASVLTLLFLLMFVFAILGFCLFGVTDRGDLENWGNLASAFFTLFSLATVDGWTDLQEELDKRKFTVSRAFTILFILLASFIFLNMFVGVMIMHTEDSMKKFERDLTLERNLAIMEEKQIILKRQQEEVNRLMNTQKSGSMNFIDMVEGFKKTLRHTDPMVLDDFSTSLSFIDIYLVTLDNQDVIVSKLQELYCEIVNVLSLMLEDMPKESSSSLSGLS
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. {ECO:0000269|PubMed:17227845, ECO:0000269|PubMed:17344468, ECO:0000269|PubMed:21412339}.
uniprot
proteins
mass_dalton
45486
uniprot
proteins
protein_family
Cation channel sperm-associated (TC 1.A.1.19) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16107607
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17227845
uniprot
proteins
pubmed
17344468
uniprot
proteins
pubmed
17347248
uniprot
proteins
pubmed
21224844
uniprot
proteins
pubmed
21412339
uniprot
proteins
pubmed
34225353
uniprot
proteins
pubmed
34998468
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:16107607, ECO:0000269|PubMed:17227845}; Multi-pass membrane protein {ECO:0000269|PubMed:34225353}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..71; /note="Helical; Name=Segment S1"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 81..107; /note="Helical; Name=Segment S2"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 109..131; /note="Helical; Name=Segment S3"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 144..160; /note="Helical; Name=Segment S4"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 169..195; /note="Helical; Name=Segment S5"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 243..268; /note="Helical; Name=Segment S6"; /evidence="ECO:0000269|PubMed:34225353
uniprot
proteins