TBC1D3G
entrez
101060321
canonical
uniprot
Q6DHY5
canonical
ensembl
ENSG00000260287
resolver
ensembl
ENSG00000275760
resolver
ensp
ENSP00000456861
resolver
ensp
ENSP00000482403
resolver
ensp
ENSP00000629444
resolver
enst
ENST00000569055
resolver
enst
ENST00000617387
resolver
enst
ENST00000959385
resolver
genesymbol
TBC1D3G
resolver
hgnc
HGNC:29860
resolver
uniprot
A8K8H9
resolver
uniprot_entry
TBC3G_HUMAN
resolver
uniprot_sec
A8K8H9
resolver
amino_acid_sequence
MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF
uniprot
proteins
function
FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
62231
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation. {ECO:0000250}.; PTM: Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination. {ECO:0000250}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
21030649
uniprot
proteins
sequence_length
549
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associated with lipid rafts. {ECO:0000250}.
uniprot
proteins