F2r
entrez
14062
canonical
uniprot
P30558
canonical
ensembl
ENSMUSG00000048376
resolver
ensp
ENSMUSP00000061754
resolver
enst
ENSMUST00000059193
resolver
genesymbol
F2r
resolver
genesymbol_syn
Cf2r
resolver
genesymbol_syn
Par1
resolver
uniprot
P97507
resolver
uniprot
Q3TVP3
resolver
uniprot_entry
PAR1_MOUSE
resolver
uniprot_sec
P97507
resolver
uniprot_sec
Q3TVP3
resolver
amino_acid_sequence
MGPRRLLIVALGLSLCGPLLSSRVPMSQPESERTDATVNPRSFFLRNPSENTFELVPLGDEEEEEKNESVLLEGRAVYLNISLPPHTPPPPFISEDASGYLTSPWLTLFMPSVYTIVFIVSLPLNVLAIAVFVLRMKVKKPAVVYMLHLAMADVLFVSVLPFKISYYFSGTDWQFGSGMCRFATAAFYGNMYASIMLMTVISIDRFLAVVYPIQSLSWRTLGRANFTCVVIWVMAIMGVVPLLLKEQTTRVPGLNITTCHDVLSENLMQGFYSYYFSAFSAIFFLVPLIVSTVCYTSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIVCFGPTNVLLIVHYLFLSDSPGTEAAYFAYLLCVCVSSVSCCIDPLIYYYASSECQRHLYSILCCKESSDPNSCNSTGQLMPSKMDTCSSHLNNSIYKKLLA
uniprot
proteins
function
FUNCTION: High affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores. The thrombin-activated receptor signaling pathway is mediated through PTX-insensitive G proteins, activation of phospholipase C resulting in the production of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) which binds to InsP3 receptors causing calcium release from the stores (By similarity). In astrocytes, the calcium released into the cytosol allows the Ca(2+)-dependent release of L-glutamate into the synaptic cleft through BEST1, that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (PubMed:25645137). May play a role in platelets activation and in vascular development (By similarity). Mediates up-regulation of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, triggered by coagulation factor Xa (F10) in cardiac fibroblasts and umbilical vein endothelial cells (By similarity). {ECO:0000250|UniProtKB:P25116, ECO:0000250|UniProtKB:P26824, ECO:0000269|PubMed:25645137}.
uniprot
proteins
mass_dalton
47790
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage by thrombin generates a new N-terminus that functions as a tethered ligand. Also proteolytically cleaved by cathepsin CTSG and GZMK. {ECO:0000250|UniProtKB:P25116}.; PTM: Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and internalization of the receptor. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
25645137
uniprot
proteins
pubmed
8678993
uniprot
proteins
pubmed
8784787
uniprot
proteins
sequence_length
430
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P26824}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P26824}.
uniprot
proteins
transmembrane_region
TRANSMEM 108..133; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 143..162; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 182..203; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 274..293; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 317..339; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 355..379; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins