CD79B
entrez
974
canonical
uniprot
P40259
canonical
ensembl
ENSG00000007312
resolver
ensp
ENSP00000006750
resolver
ensp
ENSP00000245862
resolver
ensp
ENSP00000376544
resolver
ensp
ENSP00000573795
resolver
genesymbol
CD79B
resolver
genesymbol_syn
B29
resolver
genesymbol_syn
IGB
resolver
hgnc
HGNC:1699
resolver
uniprot
Q53FS2
resolver
uniprot
Q9BU06
resolver
uniprot_entry
CD79B_HUMAN
resolver
uniprot_sec
Q53FS2
resolver
uniprot_sec
Q9BU06
resolver
amino_acid_sequence
MARLALSPVPSHWMVALLLLLSAEPVPAARSEDRYRNPKGSACSRIWQSPRFIARKRGFTVKMHCYMNSASGNVSWLWKQEMDENPQQLKLEKGRMEESQNESLATLTIQGIRFEDNGIYFCQQKCNNTSEVYQGCGTELRVMGFSTLAQLKQRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSKAGMEEDHTYEGLDIDQTATYEDIVTLRTGEVKWSVGEHPGQE
uniprot
proteins
disease_involvement
DISEASE: Agammaglobulinemia 6, autosomal recessive (AGM6) [MIM:612692]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269|PubMed:17675462}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. {ECO:0000269|PubMed:12097390, ECO:0000269|PubMed:8617796, ECO:0000269|PubMed:9057631}.
uniprot
proteins
mass_dalton
26048
uniprot
proteins
mutagenesis
MUTAGEN 55..57; /note="RKR->AAA: Blocks IgMBCR assembly."; /evidence="ECO:0000269|PubMed:35981043"; MUTAGEN 161; /note="I->W: Blocks IgMBCR assembly."; /evidence="ECO:0000269|PubMed:35981043
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.; PTM: Ubiquitinated by the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex composed of at least CUL3, KLHL6 and RBX1; leading to proteasomal degradation. {ECO:0000269|PubMed:38630892}.
uniprot
proteins
pubmed
12097390
uniprot
proteins
pubmed
1534761
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17675462
uniprot
proteins
pubmed
20696394
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
35981043
uniprot
proteins
pubmed
38630892
uniprot
proteins
pubmed
7514267
uniprot
proteins
pubmed
7643857
uniprot
proteins
pubmed
7913081
uniprot
proteins
pubmed
8419481
uniprot
proteins
pubmed
8486355
uniprot
proteins
pubmed
8617796
uniprot
proteins
pubmed
9057631
uniprot
proteins
sequence_length
229
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 160..180; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins