Clcn3
entrez
84360
canonical
uniprot
P51792
canonical
ensembl
ENSRNOG00000010682
resolver
ensembl
ENSRNOG00055013187
resolver
ensembl
ENSRNOG00060006931
resolver
ensembl
ENSRNOG00065004198
resolver
ensp
ENSRNOP00000045523
resolver
ensp
ENSRNOP00000101815
resolver
enst
ENSRNOT00000050549
resolver
enst
ENSRNOT00000163967
resolver
genesymbol
Clcn3
resolver
uniprot
A0A8L2ULZ0
resolver
uniprot
Q9R287
resolver
uniprot_entry
A0A8L2ULZ0_RAT
resolver
uniprot_entry
CLCN3_RAT
resolver
uniprot_sec
Q9R287
resolver
amino_acid_sequence
MESEQLFHRGYYRNSYNSITSASSDEELLDGAGAIMDFQTSEDDNLLDGDTAAGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGVGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRSDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGVVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN
uniprot
proteins
function
FUNCTION: [Isoform 1]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:10915634). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P51790, ECO:0000269|PubMed:10915634}.; FUNCTION: [Isoform 2]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:10915634). May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C (PubMed:8155321). It could help neuronal cells to establish short-term memory (PubMed:8155321). {ECO:0000269|PubMed:10915634, ECO:0000269|PubMed:8155321}.
uniprot
proteins
mass_dalton
90855
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P51790}.
uniprot
proteins
protein_family
Chloride channel (TC 2.A.49) family
uniprot
proteins
protein_family
ClC-3/CLCN3 subfamily
uniprot
proteins
pubmed
10915634
uniprot
proteins
pubmed
16222710
uniprot
proteins
pubmed
8155321
uniprot
proteins
sequence_length
818
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Lysosome membrane {ECO:0000250|UniProtKB:P51791}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:P51791}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:10915634}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:P51790}; Multi-pass membrane protein {ECO:0000255}. Note=In hepatocytes found in the canalicular membrane. {ECO:0000269|PubMed:10915634}.; SUBCELLULAR LOCATION: [Isoform 2]: Early endosome membrane {ECO:0000269|PubMed:16222710}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:16222710}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:10915634}; Multi-pass membrane protein {ECO:0000255}. Note=In hepatocytes found in the canalicular membrane. {ECO:0000269|PubMed:10915634}.
uniprot
proteins
transmembrane_region
TRANSMEM 126..163; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 209..232; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 258..276; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 282..301; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 349..367; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 391..416; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 423..443; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 500..520; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 525..544; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 606..624; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523
uniprot
proteins