CSF1
entrez
1435
canonical
uniprot
P09603
canonical
ensembl
ENSG00000184371
resolver
ensp
ENSP00000327513
resolver
ensp
ENSP00000358816
resolver
ensp
ENSP00000358817
resolver
ensp
ENSP00000407317
resolver
genesymbol
CSF1
resolver
hgnc
HGNC:2432
resolver
uniprot
A8K6J5
resolver
uniprot
Q13130
resolver
uniprot
Q14086
resolver
uniprot
Q14806
resolver
uniprot
Q5VVF3
resolver
uniprot
Q5VVF4
resolver
uniprot
Q9UQR8
resolver
uniprot_entry
CSF1_HUMAN
resolver
uniprot_sec
A8K6J5
resolver
uniprot_sec
Q13130
resolver
uniprot_sec
Q14086
resolver
uniprot_sec
Q14806
resolver
uniprot_sec
Q5VVF3
resolver
uniprot_sec
Q5VVF4
resolver
uniprot_sec
Q9UQR8
resolver
amino_acid_sequence
MTAPGAAGRCPPTTWLGSLLLLVCLLASRSITEEVSEYCSHMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLKSCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECSSQDVVTKPDCNCLYPKAIPSSDPASVSPHQPLAPSMAPVAGLTWEDSEGTEGSSLLPGEQPLHTVDPGSAKQRPPRSTCQSFEPPETPVVKDSTIGGSPQPRPSVGAFNPGMEDILDSAMGTNWVPEEASGEASEIPVPQGTELSPSRPGGGSMQTEPARPSNFLSASSPLPASAKGQQPADVTGTALPRVGPVRPTGQDWNHTPQKTDHPSALLRDPPEPGSPRISSLRPQGLSNPSTLSAQPQLSRSHSSGSVLPLGELEGRRSTRDRRSPAEPEGGPASEGAARPLPRFNSVPLTDTGHERQSEGSFSPQLQESVFHLLVPSVILVLLAVGGLLFYRWRRRSHQEPQRADSPLEQPEGSPLTQDDRQVELPV
uniprot
proteins
disease_involvement
DISEASE: Note=Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.; DISEASE: Note=Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.
uniprot
proteins
function
FUNCTION: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. {ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061, ECO:0000269|PubMed:8051056}.
uniprot
proteins
mass_dalton
60179
uniprot
proteins
mutagenesis
MUTAGEN 252; /note="R->A: Loss of 43 kDa subunit."; /evidence="ECO:0000269|PubMed:8051056"; MUTAGEN 309; /note="S->A: Loss of chondroitin sulfate attachment."; /evidence="ECO:0000269|PubMed:8051056"; MUTAGEN 444; /note="R->A: Does not affect production of 150-200 kDa subunit."; /evidence="ECO:0000269|PubMed:8051056"; MUTAGEN 489..554; /note="Missing: Produces biologically active protein which is secreted."; /evidence="ECO:0000269|PubMed:2460758
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:3264877}.; PTM: [Isoform 1]: N-glycosylated. {ECO:0000269|PubMed:3264877}.; PTM: [Isoform 3]: N-glycosylated. {ECO:0000269|PubMed:3264877}.; PTM: O-glycosylated; contains chondroitin sulfate (PubMed:1531650, PubMed:8051056). O-glycosylated with core 1 or possibly core 8 glycans (PubMed:22171320, PubMed:23234360, PubMed:3264877). {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:23234360, ECO:0000269|PubMed:3264877, ECO:0000269|PubMed:8051056}.; PTM: [Isoform 1]: O-glycosylated. {ECO:0000269|PubMed:3264877}.
uniprot
proteins
pubmed
1455231
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1531650
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15519852
uniprot
proteins
pubmed
16337366
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1791839
uniprot
proteins
pubmed
18687298
uniprot
proteins
pubmed
19934330
uniprot
proteins
pubmed
20504948
uniprot
proteins
pubmed
20829061
uniprot
proteins
pubmed
22171320
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23234360
uniprot
proteins
pubmed
2460758
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
2660794
uniprot
proteins
pubmed
2996129
uniprot
proteins
pubmed
3039346
uniprot
proteins
pubmed
3259875
uniprot
proteins
pubmed
3264877
uniprot
proteins
pubmed
3493529
uniprot
proteins
pubmed
3498652
uniprot
proteins
pubmed
3500041
uniprot
proteins
pubmed
8051056
uniprot
proteins
pubmed
8262907
uniprot
proteins
pubmed
8422357
uniprot
proteins
sequence_length
554
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:3264877}; Single-pass type I membrane protein {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:3264877}.; SUBCELLULAR LOCATION: [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space.
uniprot
proteins
transmembrane_region
TRANSMEM 497..517; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins