Scn2a
entrez
110876
canonical
uniprot
B1AWN6
canonical
ensembl
ENSMUSG00000075318
resolver
ensp
ENSMUSP00000028377
resolver
ensp
ENSMUSP00000097645
resolver
ensp
ENSMUSP00000143882
resolver
ensp
ENSMUSP00000172436
resolver
enst
ENSMUST00000028377
resolver
enst
ENSMUST00000100067
resolver
enst
ENSMUST00000200829
resolver
genesymbol
Scn2a
resolver
genesymbol_syn
Scn2a1
resolver
uniprot
A0A0J9YTW6
resolver
uniprot
A0A5H1ZRM8
resolver
uniprot_entry
A0A5H1ZRM8_MOUSE
resolver
uniprot_entry
SCN2A_MOUSE
resolver
uniprot_sec
A0A0J9YTW6
resolver
amino_acid_sequence
MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAISRFSATSALYILTPFNPIRKLAIKILVHSLFNVLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSTFEINITSFFNNSLDWNGTAFNRTMNMFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQAGEEEKEDAVRKSASEDSIRKKGFRFSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFKGRVKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRPSNVSQASRASRGIPTLPMNGKMHSAVDCNGVVSLVGGPSALTSPVGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSMASILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEAEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQMYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECQALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPEKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIVIQRAYRRYLLKQKVKKVSSIYKKDKGKEDEGTPIKEDIITDKLNENSTPEKTDVTPSTTSPPSYDSVTKPEKEKFEKDKSEKEDKGKDIRESKK
uniprot
proteins
function
FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:10827969, PubMed:11166117, PubMed:28137877). Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (PubMed:29867081). {ECO:0000269|PubMed:10827969, ECO:0000269|PubMed:11166117, ECO:0000269|PubMed:28137877, ECO:0000269|PubMed:29867081}.
uniprot
proteins
mass_dalton
227945
uniprot
proteins
mutagenesis
MUTAGEN 880..882; /note="GAL->QQQ: Gain of function mutation. Mutant mice display enhanced persistent sodium current, have seizures and behavioral abnormalities. Half of the mice die before four months of age, and only 10% survive to nine months. Epilepsy severity in this model is strain-dependent. Mutation in a C57BL/6J background exhibit a mild disorder, whereas animals intercrossed with SJL7/j mice show a severe phenotype."; /evidence="ECO:0000269|PubMed:11166117, ECO:0000269|PubMed:28137877
uniprot
proteins
post_translational_modification
PTM: Sumoylated at Lys-38. Sumoylation is induced by hypoxia, increases voltage-gated sodium current and mediates the early response to acute hypoxia in neurons. Sumoylated SCN2A is located at the cell membrane. {ECO:0000250|UniProtKB:P04775}.
uniprot
proteins
protein_family
Nav1.2/SCN2A subfamily
uniprot
proteins
protein_family
Sodium channel (TC 1.A.1.10) family
uniprot
proteins
pubmed
10827969
uniprot
proteins
pubmed
11166117
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28137877
uniprot
proteins
pubmed
29867081
uniprot
proteins
sequence_length
2006
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10827969}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 130..148; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 156..176; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 191..208; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 215..231; /note="Helical; Name=S4 of repeat I"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 251..270; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 402..422; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 761..779; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 791..810; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 825..844; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 847..864; /note="Helical; Name=S4 of repeat II"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 881..899; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 963..983; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1211..1228; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1242..1260; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1275..1293; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1302..1320; /note="Helical; Name=S4 of repeat III"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1338..1357; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1449..1470; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1534..1551; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1563..1581; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1594..1611; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1625..1641; /note="Helical; Name=S4 of repeat IV"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1661..1678; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1754..1776; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000250|UniProtKB:D0E0C2
uniprot
proteins