IL1RL2
entrez
8808
canonical
uniprot
Q9HB29
canonical
ensembl
ENSG00000115598
resolver
ensp
ENSP00000264257
resolver
ensp
ENSP00000413348
resolver
ensp
ENSP00000578958
resolver
ensp
ENSP00000578959
resolver
genesymbol
IL1RL2
resolver
genesymbol_syn
IL1RRP2
resolver
hgnc
HGNC:5999
resolver
uniprot
A4FU63
resolver
uniprot
Q13525
resolver
uniprot
Q45H74
resolver
uniprot
Q53TU8
resolver
uniprot
Q587I8
resolver
uniprot_entry
ILRL2_HUMAN
resolver
uniprot_sec
A4FU63
resolver
uniprot_sec
Q13525
resolver
uniprot_sec
Q45H74
resolver
uniprot_sec
Q53TU8
resolver
uniprot_sec
Q587I8
resolver
amino_acid_sequence
MWSLLLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITERAGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFRAYLIGGLIALVAVAVSVVYIYNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYPKPHKESQRHAVDALVLNILPEVLERQCGYKLFIFGRDEFPGQAVANVIDENVKLCRRLIVIVVPESLGFGLLKNLSEEQIAVYSALIQDGMKVILIELEKIEDYTVMPESIQYIKQKHGAIRWHGDFTEQSQCMKTKFWKTVRYHMPPRRCRPFPPVQLLQHTPCYRTAGPELGSRRKKCTLTTG
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. {ECO:0000250|UniProtKB:Q9ERS7, ECO:0000269|PubMed:11466363}.
uniprot
proteins
mass_dalton
65405
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
10882729
uniprot
proteins
pubmed
11466363
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16646978
uniprot
proteins
pubmed
24829417
uniprot
proteins
pubmed
8898719
uniprot
proteins
sequence_length
575
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:24829417}.
uniprot
proteins
transmembrane_region
TRANSMEM 336..356; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins