Cort
entrez
25305
canonical
uniprot
Q62949
canonical
genesymbol
Cort
resolver
uniprot_entry
CORT_RAT
resolver
amino_acid_sequence
MGGCSTRGKRPSALSLLLLLLLSGIAASALPLESGPTGQDSVQDATGGRRTGLLTFLAWWHEWASQDSSSTAFEGGTPELSKRQERPPLQQPPHRDKKPCKNFFWKTFSSCK
uniprot
proteins
function
FUNCTION: Precursor of neuropeptides that bind to all somatostatin receptor (SSTR) subtypes (By similarity). Inhibits cAMP production induced by forskolin through SSTRs (By similarity). {ECO:0000250|UniProtKB:O00230}.; FUNCTION: [Cortistatin-14]: Neuropeptide with neuronal depressant and sleep-modulating properties (PubMed:11817718, PubMed:8622767). Acts as an inhibitor of growth hormone secretion (PubMed:11817718). Acts as a ligand for Mrgprb2 receptor in mast cells (By similarity). {ECO:0000250|UniProtKB:O00230, ECO:0000269|PubMed:11817718, ECO:0000269|PubMed:8622767}.
uniprot
proteins
mass_dalton
12201
uniprot
proteins
protein_family
Somatostatin family
uniprot
proteins
pubmed
11817718
uniprot
proteins
pubmed
8622767
uniprot
proteins
sequence_length
112
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Cortistatin-14]: Secreted {ECO:0000269|PubMed:8622767}.
uniprot
proteins