A0A1B0GQX2
uniprot
A0A1B0GQX2
canonical
amino_acid_sequence
MVITSGNDEDRGGQEKESKEESVLAMLGIIGTILNLIVIIFVYIYTTL
uniprot
proteins
function
FUNCTION: In neurons, plays a role in the regulation of intracellular Ca(2+), possibly by acting as an activator of ATP2A2/SERCA2, thus increasing the efficiency with which Ca(2+) is removed from the cytoplasm (PubMed:35036403). Inhibits differentiation of embryonic stem cells into neurons and inhibits neurite outgrowth, likely as a result of its role in intracellular Ca(2+) regulation (PubMed:35036403). In pancreatic beta cells, lowers Ca(2+) levels in the endoplasmic reticulum and enhances glucose-stimulated insulin secretion (By similarity). {ECO:0000250|UniProtKB:A0A1B0GTB2, ECO:0000269|PubMed:35036403}.
uniprot
proteins
mass_dalton
5288
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
35036403
uniprot
proteins
sequence_length
48
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:35036403}; Single-pass membrane protein {ECO:0000255}. Extracellular vesicle membrane {ECO:0000269|PubMed:35036403}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..44; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins