Gcna
entrez
115489118
canonical
uniprot
A0A1D9BZF0
canonical
ensembl
ENSMUSG00000121977
resolver
genesymbol
Gcna
resolver
uniprot_entry
GCNA_MOUSE
resolver
amino_acid_sequence
MDSGSSSSSSSSGSSSGSCSTSGSGSTSGSSTTSSSSSSSSSSSSSSSSSSKEYMPELPKQRKASCVVIDSESDSDNTSDEKNTTVCEISSGDETSDIDRPGGQKLPLIVIDDDDDGSPDLKNTKQKSDEPQMSVLEKEGVECIGSDSTSPHDVCEIWDVCGSSNQTSSELEPEGEPESEAKGEPESEAKGEPESEAKGEPESEAKGESESEAKGEMETEAKGESESEAKGEMETEAKGESESEAKGEMETEAKGEPESEAKGEMETEAKGEPESEAKGEMETEAKGESESEAKGEMETEAKGESESEAKGEMETEAKGEPESEAKGEMETEAKGEPESEAKGEPEPEAAKGEMETEAAMGEVETEAAMGEPEQEITAEEAKKKRAAYLLAQQRKRKRKNRFICMSSSKPRRKRRRADPQDGADPQDGADPQDRADPQDLADPQDRGDSQDMPSLPGTSDEPIPSGQPVCPRKGMASSRGRGRGRGRGRGRGRGRGRGRGRGAKAGK
uniprot
proteins
function
FUNCTION: May play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage (PubMed:31839538). Can resolve the topoisomerase II (TOP2A) DPCs (PubMed:31839538). {ECO:0000269|PubMed:31839538}.
uniprot
proteins
mass_dalton
53394
uniprot
proteins
protein_family
Serine-aspartate repeat-containing protein (SDr) family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27718356
uniprot
proteins
pubmed
31839538
uniprot
proteins
sequence_length
507
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:31839538}. Nucleus, PML body {ECO:0000269|PubMed:31839538}. Nucleus {ECO:0000269|PubMed:27718356}. Note=Co-localizes with SUMO2 at PML bodies in all interphase cells (By similarity). Localizes on condensed chromosomes in spermatocytes in G2 and M during meiotic prophase (PubMed:31839538). {ECO:0000250|UniProtKB:Q96QF7, ECO:0000269|PubMed:31839538}.
uniprot
proteins