ANTXR1
entrez
84168
canonical
uniprot
Q9H6X2
canonical
ensembl
ENSG00000169604
resolver
ensp
ENSP00000301945
resolver
ensp
ENSP00000386494
resolver
ensp
ENSP00000387058
resolver
ensp
ENSP00000430776
resolver
ensp
ENSP00000788241
resolver
ensp
ENSP00000794578
resolver
enst
ENST00000482235
resolver
genesymbol
ANTXR1
resolver
genesymbol_syn
ATR
resolver
genesymbol_syn
TEM8
resolver
hgnc
HGNC:21014
resolver
uniprot
A8K7U8
resolver
uniprot
H0YC24
resolver
uniprot
J7K7G4
resolver
uniprot
J7KF88
resolver
uniprot
Q4ZFV6
resolver
uniprot
Q53FL1
resolver
uniprot
Q53QD8
resolver
uniprot
Q96EC6
resolver
uniprot
Q96P02
resolver
uniprot
Q9NVP3
resolver
uniprot_entry
ANTR1_HUMAN
resolver
uniprot_entry
H0YC24_HUMAN
resolver
uniprot_entry
Q53FL1_HUMAN
resolver
uniprot_entry
Q96EC6_HUMAN
resolver
uniprot_sec
A8K7U8
resolver
uniprot_sec
J7K7G4
resolver
uniprot_sec
J7KF88
resolver
uniprot_sec
Q4ZFV6
resolver
uniprot_sec
Q53QD8
resolver
uniprot_sec
Q96P02
resolver
uniprot_sec
Q9NVP3
resolver
amino_acid_sequence
MATAERRALGIGFQWLSLATLVLICAGQGGRREDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPAEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNNQPAKYPLNNAYHTSSPPPAPIYTPPPPAPHCPPPPPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPSRPPPRPSV
uniprot
proteins
disease_involvement
DISEASE: Hemangioma, capillary infantile (HCI) [MIM:602089]: A condition characterized by dull red, firm, dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring within the first two or three months of life. They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring. {ECO:0000269|PubMed:18931684}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: GAPO syndrome (GAPOS) [MIM:230740]: An autosomal recessive disease characterized by growth retardation, alopecia, failure of tooth eruption, and progressive optic atrophy in some patients. {ECO:0000269|PubMed:23602711}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2 (PubMed:30241478). {ECO:0000269|PubMed:15777794, ECO:0000269|PubMed:16762926, ECO:0000269|PubMed:30241478}.; FUNCTION: (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis. {ECO:0000269|PubMed:11700562, ECO:0000269|PubMed:12700348, ECO:0000269|PubMed:16762926, ECO:0000269|PubMed:20585457}.; FUNCTION: (Microbial infection) Mediates cell entry of Seneca Valley virus (SVV) when glycosylated. {ECO:0000269|PubMed:33924774}.
uniprot
proteins
mass_dalton
62789
uniprot
proteins
post_translational_modification
PTM: Glycosylated. Glycosylation is essential for Seneca Valley virus (SVV) attachment and entry. {ECO:0000269|PubMed:33924774}.; PTM: Phosphorylated upon PLAU binding. {ECO:0000269|PubMed:30241478}.
uniprot
proteins
protein_family
ATR family
uniprot
proteins
pubmed
10947988
uniprot
proteins
pubmed
11700562
uniprot
proteins
pubmed
12700348
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15777794
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16762926
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18931684
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
20585457
uniprot
proteins
pubmed
22912819
uniprot
proteins
pubmed
23602711
uniprot
proteins
pubmed
30241478
uniprot
proteins
pubmed
33924774
uniprot
proteins
sequence_length
564
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16762926, ECO:0000269|PubMed:30241478}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Cell projection, filopodium membrane {ECO:0000269|PubMed:16762926}; Single-pass type I membrane protein {ECO:0000269|PubMed:16762926}. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia (PubMed:16762926). Colocalizes with actin at the base of lamellipodia (PubMed:16762926). {ECO:0000269|PubMed:16762926}.
uniprot
proteins
transmembrane_region
TRANSMEM 322..342; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins