Prc1
entrez
233406
canonical
uniprot
Q99K43
canonical
ensembl
ENSMUSG00000038943
resolver
ensp
ENSMUSP00000043379
resolver
ensp
ENSMUSP00000129675
resolver
ensp
ENSMUSP00000133387
resolver
ensp
ENSMUSP00000133910
resolver
ensp
ENSMUSP00000186450
resolver
ensp
ENSMUSP00000186451
resolver
ensp
ENSMUSP00000335283
resolver
enst
ENSMUST00000047558
resolver
enst
ENSMUST00000163812
resolver
enst
ENSMUST00000173824
resolver
enst
ENSMUST00000174172
resolver
genesymbol
Prc1
resolver
uniprot
E9QPF0
resolver
uniprot
G3UW86
resolver
uniprot
G3UWQ7
resolver
uniprot
G3UY19
resolver
uniprot
Q8CE25
resolver
uniprot_entry
G3UW86_MOUSE
resolver
uniprot_entry
G3UWQ7_MOUSE
resolver
uniprot_entry
G3UY19_MOUSE
resolver
uniprot_entry
PRC1_MOUSE
resolver
uniprot_sec
E9QPF0
resolver
uniprot_sec
Q8CE25
resolver
amino_acid_sequence
MRRSEVLADESITCLQKALTHLREIWELIGIPEEQRLQRTEVVKKHIKDLLDRMIAEEESLRERLLKSISICQKELSTLCSELQVKPFQEEKDTTILQLEKDLRTQVELMRKQKKERKQELKLLQEQEQELRDILCMPPCDVDSTSVPTLEELKLFRQRVATLRETKESRREEFVNIKKQIILCMEELEHSPDTSFERDVVCEDESAFCLSLENIATLQKLLKQLEMKKSQNEAECEGLRTQIRELWDRLQIPEEEREPVEAIMTGSKTKIRNALKLEVDRLEELKMQNIKQVIEKIRVELAQFWDQCFYSQEQRQAFAPYYSEDYTENLLHLHDAEIVRLRNYYDVHKELFQGVQKWEESWKLFLEFERKASDPGRFTNRGGNLLKEEKERAKLQKTLPKLEEELKARIEQWEQEHSTAFVVNGQKFMEYVTEQWELHRLEKERAKQERQLKNKKQTEAEMLYGSTPRTPSKRPGQTPKKSGKMNTTTMSSATPNSSIRPVFGGSVYRSPMSRLPPSGSKSVVTSLCSGKKTPRAAQLRANKENLDLNGSILSGGYPGSTPLQHNCSIKSVASTYSEFSRELSKASRSDATSRILNSTNIQS
uniprot
proteins
function
FUNCTION: Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression. {ECO:0000250|UniProtKB:O43663}.
uniprot
proteins
mass_dalton
70290
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by CDK1 in early mitosis holds PRC1 in an inactive monomeric state, during the metaphase to anaphase transition, PRC1 is dephosphorylated, promoting interaction with KIF4A, which then translocates PRC1 along mitotic spindles to the plus ends of antiparallel interdigitating microtubules. Dephosphorylation also promotes MT-bundling activity by allowing dimerization. Phosphorylation by CDK1 prevents PLK1-binding: upon degradation of CDK1 at anaphase and dephosphorylation, it is then phosphorylated by PLK1, leading to cytokinesis (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
MAP65/ASE1 family
uniprot
proteins
pubmed
10727870
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
603
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43663}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Midbody {ECO:0000250|UniProtKB:O43663}. Note=Colocalized with KIF20B in the nucleus of bladder carcinoma cells at the interphase. Colocalized with KIF20B in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase. Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles, and localizes with the cell midbody during cytokinesis. Co-localizes with PRC1 in early mitosis and at the spindle midzone from anaphase B to telophase. {ECO:0000250|UniProtKB:O43663}.
uniprot
proteins