ACMSD
entrez
130013
canonical
uniprot
Q8TDX5
canonical
ensembl
ENSG00000153086
resolver
ensp
ENSP00000348459
resolver
ensp
ENSP00000376659
resolver
ensp
ENSP00000574345
resolver
genesymbol
ACMSD
resolver
hgnc
HGNC:19288
resolver
uniprot
A0A0S2Z681
resolver
uniprot
Q3B7X3
resolver
uniprot
Q53SR5
resolver
uniprot
Q6ZV40
resolver
uniprot
Q96KY2
resolver
uniprot_entry
A0A0S2Z681_HUMAN
resolver
uniprot_entry
ACMSD_HUMAN
resolver
uniprot_entry
Q6ZV40_HUMAN
resolver
uniprot_sec
Q3B7X3
resolver
uniprot_sec
Q53SR5
resolver
uniprot_sec
Q96KY2
resolver
activity_regulation
ACTIVITY REGULATION: Competitively inhibited by pyridine-2,6-dicarboxylic acid (PDC), a cyclic substrate analog (PubMed:25392945). Oligomerization increases activity (PubMed:25392945). {ECO:0000269|PubMed:25392945}.
uniprot
proteins
amino_acid_sequence
MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNALAFLGLERKQFE
uniprot
proteins
ec_number
4.1.1.45
uniprot
proteins
function
FUNCTION: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS) (PubMed:12140278, PubMed:19843166, PubMed:25392945). ACMS can be converted non-enzymatically to quinolinate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite (PubMed:12140278). ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway (PubMed:12140278, PubMed:19843166). {ECO:0000269|PubMed:12140278, ECO:0000269|PubMed:19843166, ECO:0000269|PubMed:25392945}.
uniprot
proteins
mass_dalton
38035
uniprot
proteins
mutagenesis
MUTAGEN 47; /note="R->A: Loss of aminocarboxymuconate-semialdehyde decarboxylase activity."; /evidence="ECO:0000269|PubMed:25392945"; MUTAGEN 235; /note="R->A: Loss of aminocarboxymuconate-semialdehyde decarboxylase activity."; /evidence="ECO:0000269|PubMed:25392945
uniprot
proteins
protein_family
ACMSD family
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
pubmed
12140278
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19843166
uniprot
proteins
pubmed
25392945
uniprot
proteins
sequence_length
336
uniprot
proteins