Kcnh1
entrez
65198
canonical
uniprot
Q63472
canonical
ensembl
ENSRNOG00000003841
resolver
ensp
ENSRNOP00000005209
resolver
ensp
ENSRNOP00000110242
resolver
enst
ENSRNOT00000005209
resolver
enst
ENSRNOT00000147245
resolver
genesymbol
Kcnh1
resolver
genesymbol_syn
EAG1
resolver
genesymbol_syn
Eag
resolver
uniprot
A0A8L2Q1G4
resolver
uniprot_entry
A0A8L2Q1G4_RAT
resolver
uniprot_entry
KCNH1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is inhibited by interaction with Ca(2+)-bound calmodulin (PubMed:27516594). Interaction of a single pore-forming alpha subunit with a calmodulin chain is sufficient to promote channel closure. Channel activity is not regulated by cyclic nucleotides. Channel activity is inhibited by binding intracellular phosphatidylinositol-3,5-bisphosphate and phosphatidylinositol-4,5-bisphosphate (PIP2), but is not inhibited by phosphatidylinositol 4-phosphate (By similarity). {ECO:0000250|UniProtKB:O95259, ECO:0000250|UniProtKB:Q60603, ECO:0000269|PubMed:27516594}.
uniprot
proteins
amino_acid_sequence
MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSACSFMYGELTDKDTVEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLALDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNALTDHTSANHSLVKASVVTVRESPATPVSFQAASTSTVSDHAKLHAPGSECLGPKAGGGDPAKRKGWARFKDACGKGEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVKHELKEDIKALNAKMTSIEKQLSEILRILMSRGSSQSPQDTCEVSRPQSPESDRDIFGAS
uniprot
proteins
function
FUNCTION: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate (PubMed:24495567, PubMed:27516594, PubMed:31490124, PubMed:7925287, PubMed:9400421). The activation kinetics depend on the prepulse potential and external divalent cation concentration. With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation. The time course of activation is biphasic with a fast and a slowly activating current component. Activates at more positive membrane potentials and exhibit a steeper activation curve (By similarity). Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity). {ECO:0000250|UniProtKB:O95259, ECO:0000269|PubMed:24495567, ECO:0000269|PubMed:27516594, ECO:0000269|PubMed:31490124, ECO:0000269|PubMed:7925287, ECO:0000269|PubMed:9400421}.
uniprot
proteins
mass_dalton
108291
uniprot
proteins
post_translational_modification
PTM: Channel activity is regulated via tyrosine phosphorylation/dephosphorylation by SRC and PTPN6. {ECO:0000250|UniProtKB:O95259}.
uniprot
proteins
protein_family
H (Eag) (TC 1.A.1.20) subfamily
uniprot
proteins
protein_family
Kv10.1/KCNH1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10718922
uniprot
proteins
pubmed
22841712
uniprot
proteins
pubmed
23144454
uniprot
proteins
pubmed
24495567
uniprot
proteins
pubmed
25556795
uniprot
proteins
pubmed
27516594
uniprot
proteins
pubmed
31490124
uniprot
proteins
pubmed
36331999
uniprot
proteins
pubmed
7925287
uniprot
proteins
pubmed
9400421
uniprot
proteins
pubmed
9722534
uniprot
proteins
sequence_length
962
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24495567, ECO:0000269|PubMed:27516594, ECO:0000269|PubMed:7925287, ECO:0000269|PubMed:9400421}; Multi-pass membrane protein {ECO:0000269|PubMed:27516594}. Nucleus inner membrane {ECO:0000250|UniProtKB:O95259}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O95259}. Cell projection, dendrite {ECO:0000269|PubMed:24495567}. Cell projection, axon {ECO:0000269|PubMed:24495567}. Presynaptic cell membrane {ECO:0000269|PubMed:25556795}. Perikaryon {ECO:0000269|PubMed:24495567}. Postsynaptic density membrane {ECO:0000269|PubMed:24495567}. Early endosome membrane {ECO:0000250|UniProtKB:O95259}. Note=Perinuclear KCNH1 is located to NPC-free islands. {ECO:0000250|UniProtKB:O95259}.
uniprot
proteins
transmembrane_region
TRANSMEM 221..241; /note="Helical; Name=Segment S1"; /evidence="ECO:0000269|PubMed:27516594"; TRANSMEM 249..269; /note="Helical; Name=Segment S2"; /evidence="ECO:0000269|PubMed:27516594"; TRANSMEM 291..309; /note="Helical; Name=Segment S3"; /evidence="ECO:0000269|PubMed:27516594"; TRANSMEM 319..341; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000269|PubMed:27516594"; TRANSMEM 351..372; /note="Helical; Name=Segment S5"; /evidence="ECO:0000269|PubMed:27516594"; TRANSMEM 451..471; /note="Helical; Name=Segment S6"; /evidence="ECO:0000269|PubMed:27516594
uniprot
proteins