Carnmt1
entrez
67383
canonical
uniprot
Q80UY1
canonical
ensembl
ENSMUSG00000024726
resolver
ensp
ENSMUSP00000025632
resolver
ensp
ENSMUSP00000285315
resolver
enst
ENSMUST00000025632
resolver
genesymbol
Carnmt1
resolver
uniprot
Q9CWF3
resolver
uniprot_entry
CARME_MOUSE
resolver
uniprot_sec
Q9CWF3
resolver
amino_acid_sequence
MQRRQRAPPASQPAQDGGRSEDVEVQFSAGRLGSAAPAGPPARGTAEDEERLEREHFWKVINAFRYYGTSMHERVNRTERQFRSLPENQQKLLPQFPLHLDKIRKCIDHNQEILLTIVNDCIHMFENKEYGEDANGKIMPASTFDMDKLKSTLKQFVRDWSETGKAERDACYKPIIKEIIKNFPKERWDPSKVNILVPGAGLGRLAWEVAMLGYACQGNEWSFFMLFSSNFVLNRCSEINKYKLYPWIHQFSNNRRSADQIRPILFPDVDPHSLPPGSNFSMTAGDFQEIYSECNAWDCIATCFFIDTAHNVIDYIDTIWRILKPGGIWINLGPLLYHFENLANELSIELSYEDIKNVVLQYGFQLEVEKESVLSTYTVNDLSMMKYYYECVLFVVRKPQ
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.22
uniprot
proteins
function
FUNCTION: Protein-histidine N-methyltransferase that specifically catalyzes the N1-methylation (pros-methylation) of histidine residues in a wide range of proteins. It primarily monomethylates proteins containing RNA-binding C3H1 zinc finger motifs, such as U2AF1, ZC3H15, ZC3H18, PPP1R10, PRR3 and RNF113A, thereby modulating mRNA splicing and turnover (PubMed:37612136). Additionally, it methylates the dipeptide carnosine (beta-alanyl-L-histidine) at the N1 position to generate anserine, an abundant component of vertebrate skeletal muscle. Acts also on other L-histidine-containing di- and tripeptides, such as Gly-Gly-His, Gly-His, and homocarnosine (GABA-His) (By similarity). {ECO:0000250|UniProtKB:Q8N4J0, ECO:0000269|PubMed:37612136}.
uniprot
proteins
mass_dalton
46339
uniprot
proteins
mutagenesis
MUTAGEN 199; /note="G->R: Catalytically dead; mice died around E13.5."; /evidence="ECO:0000269|PubMed:37612136
uniprot
proteins
protein_family
Carnosine N-methyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
37612136
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5BJZ6}. Nucleus {ECO:0000250|UniProtKB:Q5BJZ6}.
uniprot
proteins