CCBL1
entrez
883
canonical
uniprot
Q16773
canonical
ensembl
ENSG00000171097
resolver
ensembl
ENSG00000286112
resolver
ensp
ENSP00000302227
resolver
ensp
ENSP00000317342
resolver
ensp
ENSP00000399415
resolver
ensp
ENSP00000498386
resolver
ensp
ENSP00000566352
resolver
ensp
ENSP00000566354
resolver
ensp
ENSP00000566359
resolver
ensp
ENSP00000566362
resolver
ensp
ENSP00000566366
resolver
ensp
ENSP00000634652
resolver
ensp
ENSP00000634653
resolver
ensp
ENSP00000634661
resolver
enst
ENST00000436267
resolver
enst
ENST00000651925
resolver
genesymbol
CCBL1
resolver
genesymbol
KYAT1
resolver
genesymbol_syn
CCBL1
resolver
hgnc
HGNC:1564
resolver
uniprot
A0A494C066
resolver
uniprot
A8K563
resolver
uniprot
B7Z4W5
resolver
uniprot
J3KQH8
resolver
uniprot
Q5T275
resolver
uniprot
Q8N191
resolver
uniprot_entry
A0A494C066_HUMAN
resolver
uniprot_entry
A8K563_HUMAN
resolver
uniprot_entry
B7Z4W5_HUMAN
resolver
uniprot_entry
J3KQH8_HUMAN
resolver
uniprot_entry
KAT1_HUMAN
resolver
uniprot_sec
Q5T275
resolver
uniprot_sec
Q8N191
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by tryptophan, indole-3-pyruvic acid, 3-indolepropionic acid, DL-indole-3-lactic acid, indole-3-acetic acid (IAC), amino-oxyacetate (AOAA), aminooxy-phenylpropionic acid (AOPP) and Tris. {ECO:0000269|PubMed:19338303}.
uniprot
proteins
amino_acid_sequence
MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKVEL
uniprot
proteins
ec_number
2.6.1.64
uniprot
proteins
ec_number
2.6.1.7
uniprot
proteins
ec_number
4.4.1.13
uniprot
proteins
function
FUNCTION: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:19338303, PubMed:28097769). Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites (PubMed:7883047). Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:7883047). {ECO:0000269|PubMed:19338303, ECO:0000269|PubMed:28097769, ECO:0000269|PubMed:7883047}.
uniprot
proteins
mass_dalton
47875
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2. {ECO:0000269|PubMed:19338303, ECO:0000269|PubMed:28097769}.
uniprot
proteins
protein_family
Class-I pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15364907
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19338303
uniprot
proteins
pubmed
28097769
uniprot
proteins
pubmed
7883047
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:7883047}.
uniprot
proteins