MED8
entrez
112950
canonical
uniprot
Q96G25
canonical
ensembl
ENSG00000159479
resolver
ensp
ENSP00000290663
resolver
ensp
ENSP00000361533
resolver
ensp
ENSP00000361535
resolver
genesymbol
MED8
resolver
hgnc
HGNC:19971
resolver
uniprot
A9IZ91
resolver
uniprot
A9IZ92
resolver
uniprot
Q5JUY8
resolver
uniprot
Q96FQ4
resolver
uniprot_entry
MED8_HUMAN
resolver
uniprot_sec
A9IZ91
resolver
uniprot_sec
A9IZ92
resolver
uniprot_sec
Q5JUY8
resolver
uniprot_sec
Q96FQ4
resolver
amino_acid_sequence
MQREEKQLEASLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPTDTNALVAAVAFGKGLSNWRPSGSSGPGQAGQPGAGTILAGTSGLQQVQMAGAPSQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQR
uniprot
proteins
function
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
uniprot
proteins
mass_dalton
29080
uniprot
proteins
mutagenesis
MUTAGEN 143; /note="L->P: Impairs interaction with the Elongin BC complex; when associated with F-147."; /evidence="ECO:0000269|PubMed:12149480"; MUTAGEN 147; /note="C->F: Impairs interaction with the Elongin BC complex; when associated with P-143."; /evidence="ECO:0000269|PubMed:12149480
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
Mediator complex subunit 8 family
uniprot
proteins
pubmed
10235267
uniprot
proteins
pubmed
12149480
uniprot
proteins
pubmed
12584197
uniprot
proteins
pubmed
15175163
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15989967
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins