MARCHF9
entrez
92979
canonical
uniprot
Q86YJ5
canonical
ensembl
ENSG00000139266
resolver
ensp
ENSP00000266643
resolver
ensp
ENSP00000786632
resolver
genesymbol
MARCHF9
resolver
genesymbol_syn
MARCH9
resolver
genesymbol_syn
RNF179
resolver
hgnc
HGNC:25139
resolver
uniprot
B2R9U9
resolver
uniprot
Q86VN5
resolver
uniprot
Q8N9T1
resolver
uniprot
Q96GG2
resolver
uniprot_entry
MARH9_HUMAN
resolver
uniprot_entry
Q8N9T1_HUMAN
resolver
uniprot_sec
B2R9U9
resolver
uniprot_sec
Q86VN5
resolver
uniprot_sec
Q96GG2
resolver
amino_acid_sequence
MLKSRLRMFLNELKLLVLTGGGRPRAEPQPRGGRGGGCGWAPFAGCSTRDGDGDEEEYYGSEPRARGLAGDKEPRAGPLPPPAPPLPPPGALDALSLSSSLDSGLRTPQCRICFQGPEQGELLSPCRCDGSVRCTHQPCLIRWISERGSWSCELCYFKYQVLAISTKNPLQWQAISLTVIEKVQIAAIVLGSLFLVASISWLIWSSLSPSAKWQRQDLLFQICYGMYGFMDVVCIGLIIHEGSSVYRIFKRWQAVNQQWKVLNYDKTKDIGGDAGGGTAGKSGPRNSRTGPTSGATSRPPAAQRMRTLLPQRCGYTILHLLGQLRPPDARSSSHSGREVVMRVTTV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:17174307}.
uniprot
proteins
mass_dalton
37772
uniprot
proteins
mutagenesis
MUTAGEN 231; /note="D->N: Diminishes ability to promote MHC-I internalization."; /evidence="ECO:0000269|PubMed:17174307
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14722266
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17174307
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17174307}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins