Tbl1x
entrez
21372
canonical
uniprot
Q9QXE7
canonical
ensembl
ENSMUSG00000025246
resolver
ensp
ENSMUSP00000085549
resolver
ensp
ENSMUSP00000314379
resolver
ensp
ENSMUSP00000314381
resolver
ensp
ENSMUSP00000314386
resolver
enst
ENSMUST00000088217
resolver
genesymbol
Tbl1x
resolver
genesymbol_syn
Tbl1
resolver
uniprot
Q8BMM0
resolver
uniprot
Q8BYQ4
resolver
uniprot
Q8C0A1
resolver
uniprot_entry
TBL1X_MOUSE
resolver
uniprot_sec
Q8BMM0
resolver
uniprot_sec
Q8BYQ4
resolver
uniprot_sec
Q8C0A1
resolver
amino_acid_sequence
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQANAAAAAAAAAATATSTAATTPAAAAQQNPPKNGEATVNGEENGAHAINNHSKPMEIDGDVEIPPSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNKKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDVERGVCIHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
uniprot
proteins
function
FUNCTION: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity). {ECO:0000250|UniProtKB:O60907}.
uniprot
proteins
mass_dalton
56802
uniprot
proteins
mutagenesis
MUTAGEN 184; /note="E->A: Affects recruitment to heterochromatin by MECP2."; /evidence="ECO:0000269|PubMed:28348241"; MUTAGEN 326; /note="D->N: Affects recruitment to heterochromatin by MECP2."; /evidence="ECO:0000269|PubMed:28348241"; MUTAGEN 364; /note="E->A: Affects recruitment to heterochromatin by MECP2."; /evidence="ECO:0000269|PubMed:28348241"; MUTAGEN 382; /note="D->A: Affects recruitment to heterochromatin by MECP2. Does not interact with MECP2. Is efficiently incorporated in N-Cor repressor complex."; /evidence="ECO:0000269|PubMed:28348241"; MUTAGEN 457; /note="P->R: Does not interact with MECP2. Affects recruitment to heterochromatin by MECP2. Is efficiently incorporated in N-Cor repressor complex."; /evidence="ECO:0000269|PubMed:28348241"; MUTAGEN 459; /note="Y->F: Does not affect recruitment to heterochromatin by MECP2."; /evidence="ECO:0000269|PubMed:28348241
uniprot
proteins
protein_family
WD repeat EBI family
uniprot
proteins
pubmed
10330347
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26070566
uniprot
proteins
pubmed
28348241
uniprot
proteins
sequence_length
527
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Colocalized with MECP2 to the heterochromatin foci. {ECO:0000269|PubMed:28348241}.
uniprot
proteins