P97609
uniprot
P97609
canonical
amino_acid_sequence
MESMPSFLKDTPAWEKTAPVNGIVGQEPGTSPQDGLHHGALCLGEPVPFWRGVLSAPDSWLPPGFLQGPKDTLSVVEGEGSRNGERKANWLGSKEGLRWKEAMLAHPLAFCGPACPPRYGPLIPEHSSGHPKSDPVAFRPLHCPFLLETKILERAPFWVPTCLPPYLMSSLPPERSYDWPLAPSPWVYSGSQPKVPSAFSLGSKGFYHKDPNILRPAKEPLAASESGMLGLAPGGHLQQACDAEGPSLHQRDGETGAGRQQNLCPVFLGYPDTVPRTPWPSCPPGLVHTLGNVWAGPGSNSFGYQLGPPVTPRCPSPGPPTPPGGCCSSHLPAREGDPGPCRKCQDSPEGSSSGPGESSEERNKAGSRASPPSHHTKLKKTWLTRHSEQFECPGGCPGKGESPATGLRALKRAGSPEVQGARGPAPKRPSHTFPGTGRQGARAWQETPETSTGSKAEAQQQEEQRGPRDGRIRLRESRLEDTSCQHHLAGVTQCPSCVQAAGEVEILTSHSQKSHKLPLEEKPLEEDSCATSEEGGGSSPEASINKGLAKHLLSGLGDRLCRLLRKEREALAWAQREGQGPAMTEDSPGIPHCCSRCHHGLFNTHWRCSHCSHRLCVACGRIAGAGKNREKTGSREQRTDDCAQEAGHAACSLILTQFVSSQALAELSTVMHQVWAKFDIRGHCFCQVDARVWAPGDGGQQKEPTEKTPPAPQLSCNGDSNRTKDIKEETPDSTESPAEDRAGRSPLPCPSLCELLASTAVKLCLGHERIHMAFAPVTPALPSDDRITNILDSIIAQVVERKIQEKALGPGLRAGSGLRKGLSLPLSPVRTQLSPPGALLWLQEPRPKHGFRLFQEHWRQGQPVLVSGIQKTLRLSLWGMEALGTLGGQVQTLTALGPPQPTSLDSTAFWKGFSHPEARPKLDEGSVLLLHRPLGDKDESRVENLASSLPLPEYCAHQGKLNLASYLPLGLTLHPLEPQLWAAYGVNSHRGHLGTKNLCVEVSDLISILVHAEAQLPPWYRAQKDFLSGLDGEGLWSPGSQTSTVWHVFRAQDAQRIRRFLQMVCPAGAGTLEPGAPGSCYLDSGLRRRLREEWGVSCWTLLQAPGEAVLVPAGAPHQVQGLVSTISVTQHFLSPETSALSAQLCHQGASLPPDHRMLYAQMDRAVFQAVKVAVGTLQEAK
uniprot
proteins
ec_number
1.14.11.65
uniprot
proteins
function
FUNCTION: Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. {ECO:0000250|UniProtKB:O43593}.
uniprot
proteins
mass_dalton
127307
uniprot
proteins
mutagenesis
MUTAGEN 563..564; /note="LL->AA: Decreases RORA protein stability. Strongly decreases RORA protein stability; when associated with 752-L--A-756."; /evidence="ECO:0000269|PubMed:14570920"; MUTAGEN 755..756; /note="LL->AA: Decreases RORA protein stability. Strongly decreases RORA protein stability; when associated with 560-L--A-564.
uniprot
proteins
pubmed
14570920
uniprot
proteins
pubmed
8987811
uniprot
proteins
sequence_length
1181
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins