Cyp26a1
entrez
13082
canonical
uniprot
O55127
canonical
ensembl
ENSMUSG00000024987
resolver
ensp
ENSMUSP00000025946
resolver
enst
ENSMUST00000025946
resolver
genesymbol
Cyp26a1
resolver
genesymbol_syn
Cyp26
resolver
genesymbol_syn
P450ra
resolver
uniprot
A0A0R4J061
resolver
uniprot
Q9R1F4
resolver
uniprot_entry
A0A0R4J061_MOUSE
resolver
uniprot_entry
CP26A_MOUSE
resolver
uniprot_sec
Q9R1F4
resolver
amino_acid_sequence
MGLPALLASALCTFVLPLLLFLAALKLWDLYCVSSRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGAGCLSNLHDSSHKQRKKVIMQAFSREALQCYVLVIAEEVSSCLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPGPAGGGEDEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGVKARNLIHARIEENIRAKIRRLQATEPDGGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEIKSKGLLCKSNQDNKLDMETLEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVADIFTNKEEFNPDRFIVPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTYFQGDI
uniprot
proteins
ec_number
1.14.13.-
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (PubMed:15911617, PubMed:9250660, PubMed:9442090). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (By similarity). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (PubMed:15911617, PubMed:9250660, PubMed:9442090). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (By similarity). Involved in the conversion of atRA to all-trans-4-oxo-RA (PubMed:15911617). Able to metabolize other RAs such as 9-cis, 13-cis and 9,13-di-cis RA (PubMed:9250660). Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (Probable). May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (By similarity). {ECO:0000250|UniProtKB:O43174, ECO:0000269|PubMed:15911617, ECO:0000269|PubMed:9250660, ECO:0000269|PubMed:9442090, ECO:0000305|PubMed:15911617}.
uniprot
proteins
mass_dalton
56178
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
11063033
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15911617
uniprot
proteins
pubmed
9250660
uniprot
proteins
pubmed
9442090
uniprot
proteins
sequence_length
497
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43174}; Peripheral membrane protein. Microsome membrane {ECO:0000250|UniProtKB:O43174}; Peripheral membrane protein.
uniprot
proteins