HNMT
entrez
3176
canonical
uniprot
P50135
canonical
ensembl
ENSG00000150540
resolver
ensp
ENSP00000280096
resolver
ensp
ENSP00000280097
resolver
ensp
ENSP00000333259
resolver
ensp
ENSP00000644847
resolver
genesymbol
HNMT
resolver
hgnc
HGNC:5028
resolver
uniprot
B2R9J3
resolver
uniprot
B4DWC1
resolver
uniprot
Q546Z6
resolver
uniprot
Q7Z7I2
resolver
uniprot
Q8IU56
resolver
uniprot
Q8WW98
resolver
uniprot
Q9BRW6
resolver
uniprot_entry
B4DWC1_HUMAN
resolver
uniprot_entry
HNMT_HUMAN
resolver
uniprot_sec
B2R9J3
resolver
uniprot_sec
Q546Z6
resolver
uniprot_sec
Q7Z7I2
resolver
uniprot_sec
Q8IU56
resolver
uniprot_sec
Q8WW98
resolver
uniprot_sec
Q9BRW6
resolver
amino_acid_sequence
MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, autosomal recessive 51 (MRT51) [MIM:616739]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269|PubMed:26206890}. Note=The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry.
uniprot
proteins
ec_number
2.1.1.8
uniprot
proteins
function
FUNCTION: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. {ECO:0000269|PubMed:26206890}.
uniprot
proteins
mass_dalton
33295
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
HNMT family
uniprot
proteins
pubmed
10803682
uniprot
proteins
pubmed
11566133
uniprot
proteins
pubmed
14667820
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26206890
uniprot
proteins
pubmed
7943261
uniprot
proteins
pubmed
8145732
uniprot
proteins
pubmed
8605025
uniprot
proteins
pubmed
9547362
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26206890}.
uniprot
proteins