Hcst
entrez
474146
canonical
uniprot
Q6X9T8
canonical
ensembl
ENSRNOG00000020849
resolver
ensembl
ENSRNOG00055031195
resolver
ensembl
ENSRNOG00060029564
resolver
ensembl
ENSRNOG00065031531
resolver
ensp
ENSRNOP00000028287
resolver
ensp
ENSRNOP00055044727
resolver
ensp
ENSRNOP00060042710
resolver
ensp
ENSRNOP00065044715
resolver
enst
ENSRNOT00000028287
resolver
enst
ENSRNOT00055054076
resolver
enst
ENSRNOT00060051344
resolver
enst
ENSRNOT00065054348
resolver
genesymbol
Hcst
resolver
genesymbol_syn
Dap10
resolver
uniprot_entry
HCST_RAT
resolver
amino_acid_sequence
MAPPGHLLFLFLLPVAASQTNEGSCSGCGPLSLPLLAGLVAADAVMSLLIVGVVFVCMRLHSRPAQEDGRVYINMPGRG
uniprot
proteins
function
FUNCTION: Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as a docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
8205
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; PIK3R1 and GRB2 associate specifically with tyrosine-phosphorylated HCST. {ECO:0000250}.; PTM: O-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
DAP10 family
uniprot
proteins
sequence_length
79
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins