Orai3
entrez
269999
canonical
uniprot
Q6P8G8
canonical
ensembl
ENSMUSG00000043964
resolver
ensp
ENSMUSP00000050279
resolver
enst
ENSMUST00000061587
resolver
genesymbol
Orai3
resolver
genesymbol_syn
Tmem142c
resolver
uniprot
A3KCG3
resolver
uniprot_entry
A3KCG3_MOUSE
resolver
uniprot_entry
ORAI3_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: CRAC channels are regulated by fast Ca(2+)-dependent inactivation (FCDI), a mechanism that limits Ca(2+) influx and cell toxicity. ORAI3 subunit displays prominent FCDI. Inhibited by lanthanides such as Gd(3+) ions. {ECO:0000250|UniProtKB:Q9BRQ5}.
uniprot
proteins
amino_acid_sequence
MKGGEGDTGEQAPLNPEVDSPAGSATYREFVHRGYLDLMGASQHSLRALSWRRLYLSRAKLKASSRTSALLSGFAMVAMVEVQLENDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTALGTFLFLAEVVLVGWVKFVPIGAPMGKPAPVVPMSQVPPVTVSLSLASNLTPSSASITTSQQPSKACPPRQVCDSAHGPGWQAAMASTAIMVPVGLVFMAFALHFYRSLVAHKTDRHKQELEELSRLQGELQAV
uniprot
proteins
function
FUNCTION: Pore-forming subunit of two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels. Assembles with ORAI1 and ORAI2 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription. Assembles with ORAI1 to form channels that mediate store-independent Ca(2+) influx in response to inflammatory metabolites arachidonate or its derivative leukotriene C4, termed ARC and LRC channels respectively. {ECO:0000250|UniProtKB:Q9BRQ5}.
uniprot
proteins
mass_dalton
31358
uniprot
proteins
protein_family
Orai family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
290
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BRQ5}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with STIM1 upon store depletion. {ECO:0000250|UniProtKB:Q9BRQ5}.
uniprot
proteins
transmembrane_region
TRANSMEM 63..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 95..115; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 157..177; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 239..259; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins