Eloc
entrez
67923
canonical
uniprot
P83940
canonical
ensembl
ENSMUSG00000079658
resolver
ensp
ENSMUSP00000111009
resolver
ensp
ENSMUSP00000139480
resolver
ensp
ENSMUSP00000139675
resolver
ensp
ENSMUSP00000140422
resolver
ensp
ENSMUSP00000140962
resolver
ensp
ENSMUSP00000274315
resolver
ensp
ENSMUSP00000274316
resolver
ensp
ENSMUSP00000274323
resolver
ensp
ENSMUSP00000274324
resolver
ensp
ENSMUSP00000274329
resolver
ensp
ENSMUSP00000274334
resolver
ensp
ENSMUSP00000274335
resolver
ensp
ENSMUSP00000361036
resolver
enst
ENSMUST00000115352
resolver
enst
ENSMUST00000185771
resolver
enst
ENSMUST00000186948
resolver
enst
ENSMUST00000187910
resolver
enst
ENSMUST00000188641
resolver
genesymbol
Eloc
resolver
genesymbol_syn
Tceb1
resolver
uniprot
A0A087WNT1
resolver
uniprot
Q63182
resolver
uniprot_entry
A0A087WNT1_MOUSE
resolver
uniprot_entry
ELOC_MOUSE
resolver
uniprot_sec
Q63182
resolver
amino_acid_sequence
MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
uniprot
proteins
function
FUNCTION: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites (By similarity). Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (PubMed:27863225, PubMed:27863226). {ECO:0000250|UniProtKB:Q15369, ECO:0000269|PubMed:27863225, ECO:0000269|PubMed:27863226}.; FUNCTION: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins (PubMed:33590678, PubMed:35978186). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes (By similarity). Component the von Hippel-Lindau ubiquitination complex CBC(VHL) (By similarity). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The ECS(ASB9) complex mediates ubiquitination and degradation of CKB (By similarity). As part of a multisubunit ubiquitin ligase complex, polyubiquitinates monoubiquitinated POLR2A (By similarity). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (PubMed:33590678). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (By similarity). The ECS(ASB7) complex acts a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1 (By similarity). As part of the ECS(LRRC58) complex, mediates CDO1 ubiquitination and degradation, regulating cysteine catabolism (By similarity). {ECO:0000250|UniProtKB:Q15369, ECO:0000269|PubMed:33590678, ECO:0000269|PubMed:35978186}.
uniprot
proteins
mass_dalton
12473
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:33590678, ECO:0000269|PubMed:35978186}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the DCX(AMBRA1) complex, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:Q15369}.
uniprot
proteins
protein_family
SKP1 family
uniprot
proteins
pubmed
10051596
uniprot
proteins
pubmed
11384984
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16498413
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23897481
uniprot
proteins
pubmed
27863225
uniprot
proteins
pubmed
27863226
uniprot
proteins
pubmed
28061330
uniprot
proteins
pubmed
33590678
uniprot
proteins
pubmed
35978186
uniprot
proteins
pubmed
9869640
uniprot
proteins
sequence_length
112
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:33590678}.
uniprot
proteins