PTPRJ
entrez
5795
canonical
uniprot
Q12913
canonical
ensembl
ENSG00000149177
resolver
ensp
ENSP00000400010
resolver
ensp
ENSP00000409733
resolver
genesymbol
PTPRJ
resolver
genesymbol_syn
DEP1
resolver
hgnc
HGNC:9673
resolver
uniprot
E9PG76
resolver
uniprot
Q15255
resolver
uniprot
Q6P4H4
resolver
uniprot
Q8NHM2
resolver
uniprot
Q9NPR5
resolver
uniprot
Q9UDA9
resolver
uniprot_entry
PTPRJ_HUMAN
resolver
uniprot_entry
Q9NPR5_HUMAN
resolver
uniprot_sec
E9PG76
resolver
uniprot_sec
Q15255
resolver
uniprot_sec
Q6P4H4
resolver
uniprot_sec
Q8NHM2
resolver
uniprot_sec
Q9UDA9
resolver
amino_acid_sequence
MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIYENLAPVTTFGKTNGYIA
uniprot
proteins
disease_involvement
DISEASE: Thrombocytopenia 10 (THC10) [MIM:620484]: A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. THC10 is an autosomal recessive form characterized by decreased numbers of platelets apparent from birth or early childhood. {ECO:0000269|PubMed:30591527}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (PubMed:10821867, PubMed:12062403, PubMed:12370829, PubMed:12475979, PubMed:18348712, PubMed:19494114, PubMed:19922411, PubMed:21262971). Plays a role in cell adhesion, migration, proliferation and differentiation (PubMed:12370829, PubMed:14709717, PubMed:16682945, PubMed:19836242). Has a role in megakaryocytes and platelet formation (PubMed:30591527). Involved in vascular development (By similarity). Regulator of macrophage adhesion and spreading (By similarity). Positively affects cell-matrix adhesion (By similarity). Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation (PubMed:16682945). Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR (PubMed:21091576). Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation (PubMed:18936167). Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation (PubMed:19836242). Enhances the barrier function of epithelial junctions during reassembly (PubMed:19332538). Negatively regulates T-cell receptor (TCR) signaling (PubMed:11259588, PubMed:9531590, PubMed:9780142). Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling (PubMed:11259588, PubMed:12913111). {ECO:0000250|UniProtKB:Q64455, ECO:0000269|PubMed:10821867, ECO:0000269|PubMed:11259588, ECO:0000269|PubMed:12062403, ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:12913111, ECO:0000269|PubMed:14709717, ECO:0000269|PubMed:16682945, ECO:0000269|PubMed:18348712, ECO:0000269|PubMed:18936167, ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:19494114, ECO:0000269|PubMed:19836242, ECO:0000269|PubMed:19922411, ECO:0000269|PubMed:21091576, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:30591527, ECO:0000269|PubMed:9531590, ECO:0000269|PubMed:9780142}.; FUNCTION: [Isoform 2]: Activates angiogenesis and cell migration (PubMed:28052032). Down-regulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1 (PubMed:28052032). {ECO:0000269|PubMed:28052032}.
uniprot
proteins
mass_dalton
145941
uniprot
proteins
mutagenesis
MUTAGEN 1016; /note="K->A: 80% decrease in interaction with MAPK1 and MAPK3."; /evidence="ECO:0000269|PubMed:19494114"; MUTAGEN 1205; /note="D->A: Substrate trapping with much higher affinity for substrate."; /evidence="ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:18348712, ECO:0000269|PubMed:18936167, ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:19494114, ECO:0000269|PubMed:19836242, ECO:0000269|PubMed:21262971"; MUTAGEN 1239; /note="C->S: Catalytically inactive and substrate trapping with higher affinity for substrate."; /evidence="ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:18936167, ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:19836242, ECO:0000269|PubMed:21262971
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated. {ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:9531590}.; PTM: [Isoform 2]: N-glycosylated. {ECO:0000269|PubMed:28052032}.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 3 subfamily
uniprot
proteins
pubmed
10821867
uniprot
proteins
pubmed
11259588
uniprot
proteins
pubmed
12062403
uniprot
proteins
pubmed
12089527
uniprot
proteins
pubmed
12370829
uniprot
proteins
pubmed
12475979
uniprot
proteins
pubmed
12913111
uniprot
proteins
pubmed
14709717
uniprot
proteins
pubmed
15378013
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16682945
uniprot
proteins
pubmed
16778204
uniprot
proteins
pubmed
18348712
uniprot
proteins
pubmed
18603590
uniprot
proteins
pubmed
18936167
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19246339
uniprot
proteins
pubmed
19332538
uniprot
proteins
pubmed
19494114
uniprot
proteins
pubmed
19836242
uniprot
proteins
pubmed
19922411
uniprot
proteins
pubmed
21091576
uniprot
proteins
pubmed
21262971
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28052032
uniprot
proteins
pubmed
30552125
uniprot
proteins
pubmed
30591527
uniprot
proteins
pubmed
33296397
uniprot
proteins
pubmed
7937872
uniprot
proteins
pubmed
7994032
uniprot
proteins
pubmed
8483328
uniprot
proteins
pubmed
9531590
uniprot
proteins
pubmed
9780142
uniprot
proteins
sequence_length
1337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane {ECO:0000250}. Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted, extracellular space {ECO:0000269|PubMed:28052032}.
uniprot
proteins
transmembrane_region
TRANSMEM 976..996; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins