SLC5A3
entrez
6526
canonical
uniprot
P53794
canonical
ensembl
ENSG00000198743
resolver
ensp
ENSP00000370543
resolver
enst
ENST00000381151
resolver
genesymbol
SLC5A3
resolver
hgnc
HGNC:11038
resolver
uniprot
O43489
resolver
uniprot_entry
SC5A3_HUMAN
resolver
uniprot_sec
O43489
resolver
amino_acid_sequence
MRAVLDTADIAIVALYFILVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGHRIQVYFAALSLILYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMIISIMEIGGFEEVKRRYMLASPDVTSILLTYNLSNTNSCNVSPKKEALKMLRNPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRILFTDDIACINPEHCMLVCGSRAGCSNIAYPRLVMKLVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLIRKSASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVLGAVRLILAFAYRAPECDQPDNRPGFIKDIHYMYVATGLFWVTGLITVIVSLLTPPPTKEQIRTTTFWSKKNLVVKENCSPKEEPYKMQEKSILRCSENNETINHIIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASLGHSEAETPVDAYSNGQAALMGEKERKKETDDGGRYWKFIDWFCGFKSKSLSKRSLRDLMEEEAVCLQMLEETRQVKVILNIGLFAVCSLGIFMFVYFSL
uniprot
proteins
function
FUNCTION: Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity). Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (By similarity). Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel. In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter (PubMed:24595108, PubMed:28793216). Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity) (PubMed:24595108). Associates with KCNQ2-KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (PubMed:28793216). Provides myo-inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide-dependent ion channels and Ca(2+) signaling upon osmotic stress (PubMed:27217553). {ECO:0000250|UniProtKB:P31637, ECO:0000250|UniProtKB:Q9JKZ2, ECO:0000269|PubMed:24595108, ECO:0000269|PubMed:27217553, ECO:0000269|PubMed:28793216}.
uniprot
proteins
mass_dalton
79664
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
21679696
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24595108
uniprot
proteins
pubmed
27217553
uniprot
proteins
pubmed
28793216
uniprot
proteins
pubmed
7789985
uniprot
proteins
pubmed
9441750
uniprot
proteins
sequence_length
718
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9JKZ2}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9JKZ2}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with KCNQ1 at the apical membrane of choroid plexus epithelium. {ECO:0000250|UniProtKB:Q9JKZ2}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 39..57; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 124..144; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 158..183; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 187..205; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 304..324; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 354..376; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 407..430; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 444..462; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 511..532; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 696..716; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins