CHAF1B
entrez
8208
canonical
uniprot
Q13112
canonical
ensembl
ENSG00000159259
resolver
ensp
ENSP00000315700
resolver
ensp
ENSP00000548667
resolver
enst
ENST00000314103
resolver
enst
ENST00000878608
resolver
genesymbol
CHAF1B
resolver
genesymbol_syn
CAF1A
resolver
genesymbol_syn
CAF1P60
resolver
genesymbol_syn
MPHOSPH7
resolver
genesymbol_syn
MPP7
resolver
hgnc
HGNC:1911
resolver
uniprot
Q99548
resolver
uniprot_entry
CAF1B_HUMAN
resolver
uniprot_sec
Q99548
resolver
amino_acid_sequence
MKVITCEIAWHNKEPVYSLDFQHGTAGRIHRLASAGVDTNVRIWKVEKGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVATLSCDRVLRVYSIQKKRVAFNVSKMLSGIGAEGEARSYRMFHDDSMKSFFRRLSFTPDGSLLLTPAGCVESGENVMNTTYVFSRKNLKRPIAHLPCPGKATLAVRCCPVYFELRPVVETGVELMSLPYRLVFAVASEDSVLLYDTQQSFPFGYVSNIHYHTLSDISWSSDGAFLAISSTDGYCSFVTFEKDELGIPLKEKPVLNMRTPDTAKKTKSQTHRGSSPGPRPVEGTPASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSPLPGPSEEKTLQPSSQNTKAHPSRRVTLNTLQAWSKTTPRRINLTPLKTDTPPSSVPTSVISTPSTEEIQSETPGDAQGSPPELKRPRLDENKGGTESLDP
uniprot
proteins
function
FUNCTION: Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}.
uniprot
proteins
mass_dalton
61493
uniprot
proteins
post_translational_modification
PTM: Differentially phosphorylated during cell cycle. During mitosis the p60 subunit of inactive CAF-1 is hyperphosphorylated and displaced into the cytosol. Progressively dephosphorylated from G1 to S and G2 phase. Phosphorylated p60 is recruited to chromatin undergoing DNA repair after UV irradiation in G1, S or G2 phases. {ECO:0000269|PubMed:8885239, ECO:0000269|PubMed:9614144}.
uniprot
proteins
protein_family
WD repeat HIR1 family
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
10893180
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
33857403
uniprot
proteins
pubmed
7600578
uniprot
proteins
pubmed
8885239
uniprot
proteins
pubmed
9614144
uniprot
proteins
pubmed
9813080
uniprot
proteins
sequence_length
559
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9614144}. Cytoplasm {ECO:0000269|PubMed:9614144}. Note=DNA replication foci. Cytoplasmic in M phase.
uniprot
proteins