IL2
entrez
3558
canonical
uniprot
P60568
canonical
ensembl
ENSG00000109471
resolver
ensp
ENSP00000226730
resolver
enst
ENST00000226730
resolver
genesymbol
IL2
resolver
hgnc
HGNC:6001
resolver
uniprot
P01585
resolver
uniprot
Q0GK43
resolver
uniprot_entry
IL2_HUMAN
resolver
uniprot_entry
Q0GK43_HUMAN
resolver
uniprot_sec
P01585
resolver
amino_acid_sequence
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. {ECO:0000269|PubMed:1396583}.
uniprot
proteins
function
FUNCTION: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance (PubMed:6438535). Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG) (PubMed:16293754, PubMed:16477002). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3 (PubMed:7973659). In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5 (PubMed:8580378). This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways (PubMed:25142963). Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well (PubMed:6608729). Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production (PubMed:6438535). Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells. {ECO:0000269|PubMed:16293754, ECO:0000269|PubMed:16477002, ECO:0000269|PubMed:25142963, ECO:0000269|PubMed:6438535, ECO:0000269|PubMed:6608729, ECO:0000269|PubMed:7973659, ECO:0000269|PubMed:8580378}.
uniprot
proteins
mass_dalton
17628
uniprot
proteins
protein_family
IL-2 family
uniprot
proteins
pubmed
1396583
uniprot
proteins
pubmed
1510960
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16293754
uniprot
proteins
pubmed
1631562
uniprot
proteins
pubmed
16477002
uniprot
proteins
pubmed
25142963
uniprot
proteins
pubmed
2793860
uniprot
proteins
pubmed
3264184
uniprot
proteins
pubmed
3491296
uniprot
proteins
pubmed
3500515
uniprot
proteins
pubmed
6306584
uniprot
proteins
pubmed
6312994
uniprot
proteins
pubmed
6324170
uniprot
proteins
pubmed
6330695
uniprot
proteins
pubmed
6333684
uniprot
proteins
pubmed
6403867
uniprot
proteins
pubmed
6438535
uniprot
proteins
pubmed
6608729
uniprot
proteins
pubmed
7529123
uniprot
proteins
pubmed
7722480
uniprot
proteins
pubmed
7973659
uniprot
proteins
pubmed
8580378
uniprot
proteins
pubmed
8824916
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins