Clpx
entrez
270166
canonical
uniprot
Q9JHS4
canonical
ensembl
ENSMUSG00000015357
resolver
ensp
ENSMUSP00000015501
resolver
ensp
ENSMUSP00000109455
resolver
enst
ENSMUST00000015501
resolver
enst
ENSMUST00000113824
resolver
genesymbol
Clpx
resolver
uniprot
E9QLZ8
resolver
uniprot
F6V9N8
resolver
uniprot
Q6P8N8
resolver
uniprot
Q8C4Z5
resolver
uniprot
Q9WVD1
resolver
uniprot_entry
CLPX_MOUSE
resolver
uniprot_entry
F6V9N8_MOUSE
resolver
uniprot_entry
Q6P8N8_MOUSE
resolver
uniprot_entry
Q8C4Z5_MOUSE
resolver
uniprot_sec
E9QLZ8
resolver
uniprot_sec
Q9WVD1
resolver
amino_acid_sequence
MSSCGACTCGAAAARLLTTSLTSAQRGISCGRIHVPVLGRLGTTLDAQALRRAPLRTFSETPAYFASKDGANKDGSGDGNKKSVTEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEAEKQTSLTPRELEIRRREDEYRFTKLLQIAGISPHGNALGASMQQQVNQQMPQEKRGGEVLDSSQDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNVLFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEEKDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCELNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIRAPSKESSEEEYDSGVEEDGWPRQADAANS
uniprot
proteins
ec_number
3.6.4.10
uniprot
proteins
function
FUNCTION: ATP-dependent chaperone that functions as an unfoldase. As part of the ClpXP protease complex, it recognizes specific protein substrates, unfolds them using energy derived from ATP hydrolysis, and then translocates them to the proteolytic subunit (CLPP) of the ClpXP complex for degradation (PubMed:10347188). Thanks to its chaperone activity, it also functions in the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis (By similarity). This chaperone is also involved in the control of mtDNA nucleoid distribution, by regulating mitochondrial transcription factor A (TFAM) activity (By similarity). {ECO:0000250|UniProtKB:O76031, ECO:0000269|PubMed:10347188}.
uniprot
proteins
mass_dalton
69229
uniprot
proteins
mutagenesis
MUTAGEN 300; /note="K->A: Loss of ATP hydrolysis."; /evidence="ECO:0000269|PubMed:10347188
uniprot
proteins
protein_family
ClpX chaperone family
uniprot
proteins
pubmed
10347188
uniprot
proteins
pubmed
11003706
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22710082
uniprot
proteins
sequence_length
634
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22710082}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:O76031}.
uniprot
proteins