Ntsr1
entrez
18216
canonical
uniprot
O88319
canonical
ensembl
ENSMUSG00000027568
resolver
ensp
ENSMUSP00000029084
resolver
ensp
ENSMUSP00000127548
resolver
enst
ENSMUST00000029084
resolver
enst
ENSMUST00000170448
resolver
genesymbol
Ntsr1
resolver
genesymbol_syn
Ntsr
resolver
uniprot
A2ACT4
resolver
uniprot_entry
A2ACT4_MOUSE
resolver
uniprot_entry
NTR1_MOUSE
resolver
amino_acid_sequence
MHLNSSVQQGAPSEPGAQPFPHPQFGLETMLLALSLSNGSGNSSESILEPNSNLDVNTDIYSKVLVTAVYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGLQNRSADGQHPGGLVCTPTVDTATVKVVIQVNTFMSFLFPMLIISILNTVIANKLTVMVHQAAEQGRGVCTVGTHNSLEHSTFNMSIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWRRRRKKRPTFSRKPNSMSSNHAFSTSATRETLY
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis. {ECO:0000250|UniProtKB:P30989}.
uniprot
proteins
mass_dalton
47217
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P30989}.; PTM: Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment. {ECO:0000250|UniProtKB:P30989}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
NTSR1 sub-subfamily
uniprot
proteins
protein_family
Neurotensin receptor subfamily
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P30989}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30989}. Membrane raft {ECO:0000250|UniProtKB:P30989}. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts. {ECO:0000250|UniProtKB:P30989}.
uniprot
proteins
transmembrane_region
TRANSMEM 68..88; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 103..122; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 143..164; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 185..205; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 235..259; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 309..330; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 349..369; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P20789
uniprot
proteins