Q3T9M1
uniprot
Q3T9M1
canonical
amino_acid_sequence
MSVPHGPTPAPVAEPHTQEPGSDKRDGRLSVCTKVCYGIGGVPNQVASSASAFYLQLFLLDVAQIPAAQVSLALFGGKVSGAVADPVAGFFINKSRRTGSGRLMPWALGCMPLIALAYFFLWFLPPFTSLRGLWYTSFYCLFQALATFFQVPYTALTMILTPSPRERDSATAYRMTMEMAGTLMGATVHGLIVSSAHGSQRCEDTVHPRSPAVSPDVARLYCIAAAVVALTYPVCGSLLCLGVKEQPDTSAPASGQGLNFFTGLAITSQHPPYLSLVVSFLFISAAVQVEQSYLVLFCTHASKLQDHVQNLVLIILVSAVLSTPLWEWVLQRFGKKTSAFGICVMVPFSILLAAVPSAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLQHRCGPGVETIFYSSYVFFTKLSGAGALGISTLSLEFAGCEAGACQQAEEVVVTLKVLIGAVPTCMILIGLCILLVGPTPKMPRQDTSSQLSLRRRTSYSLA
uniprot
proteins
function
FUNCTION: Lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets (PubMed:29045386, PubMed:29563527, PubMed:33334894, PubMed:33863882). Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (PubMed:29045386). Sphingosine-1-phosphate export from platelets is required for platelet aggregation and thrombus formation (PubMed:33863882). Mediates the export of different sphingosine-1-phosphate (S1P) species, including S1P(d18:0) (sphinganine 1-phosphate), S1P (d18:1) (sphing-4-enine 1-phosphate) and S1P (d18:2) (sphinga-4E,14Z-dienine-1-phosphate) (PubMed:33863882). Release of sphingosine-1-phosphate is facilitated by a proton gradient (PubMed:33334894). In contrast, cations, such as sodium, are not required to drive sphingosine-1-phosphate transport (PubMed:29563527, PubMed:33334894). In addition to export, also able to mediate S1P import (PubMed:33785361). Does not transport lysophosphatidylcholine (LPC) (PubMed:29045386). {ECO:0000269|PubMed:29045386, ECO:0000269|PubMed:29563527, ECO:0000269|PubMed:33334894, ECO:0000269|PubMed:33785361, ECO:0000269|PubMed:33863882}.
uniprot
proteins
mass_dalton
52797
uniprot
proteins
mutagenesis
MUTAGEN 85; /note="D->A: Decreased sphingosine-1-phosphate transport."; /evidence="ECO:0000269|PubMed:29563527, ECO:0000269|PubMed:33334894"; MUTAGEN 147; /note="T->A: Decreased export of sphingosine-1-phosphate."; /evidence="ECO:0000269|PubMed:33334894"; MUTAGEN 413; /note="K->A: Decreased sphingosine-1-phosphate transport."; /evidence="ECO:0000269|PubMed:29563527
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18694395
uniprot
proteins
pubmed
29045386
uniprot
proteins
pubmed
29563527
uniprot
proteins
pubmed
33334894
uniprot
proteins
pubmed
33785361
uniprot
proteins
pubmed
33863882
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29045386, ECO:0000269|PubMed:29563527, ECO:0000269|PubMed:33863882}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the cell membrane and intracellular membranes. {ECO:0000269|PubMed:29045386}.
uniprot
proteins
transmembrane_region
TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 223..243; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 310..330; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 339..359; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 360..380; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 402..422; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 449..469; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins