Timeless
entrez
83508
canonical
uniprot
Q9Z2Y1
canonical
ensembl
ENSRNOG00000031916
resolver
ensp
ENSRNOP00000070516
resolver
ensp
ENSRNOP00000085093
resolver
enst
ENSRNOT00000083899
resolver
enst
ENSRNOT00000116339
resolver
genesymbol
Timeless
resolver
uniprot
A0A0G2JY47
resolver
uniprot
A0A8I6GBL8
resolver
uniprot_entry
A0A0G2JY47_RAT
resolver
uniprot_entry
A0A8I6GBL8_RAT
resolver
uniprot_entry
TIM_RAT
resolver
amino_acid_sequence
MDLYMMNCELLATCSALGYLEGGTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDLLPILTQHRQDKPLFDAVIRLMVNLTQPALLCFGSVPKDPTVRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEDRQEEDNLLIERILLLVRNILHVPANLEQEKRIDDDASIHDRLLWAIHLSGMDDLLLFLSSSSAEQQWSLHVLEIISLMFRDQKPEQLAGVGQGRLAQERSTDLAELEVLRQREVAEKRARALQRGNRHSRFGGSYVVQGLKSIGERDVVFHKGLHNLQNYSSDLGKQPRRVPKRRQAAQELSVHRRSVLNVRLFLRDFCSEFLENCYNPLMGAVKDHLLREKAQQHDETYYMWAMAFFMAFNRAAAFRPGFVSETLSIRTFHFVEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEMDMCPDDAVRESSRIIKNNIFYMMEYRELFLALFRKFDERYHPRSFLCDLVETTHLFLKMLERFCRSRGNLMVQNKRKKRKKKKKAQEQGVAFSRSPEELQAMWSALAERLLQCAQEPELSVDSIIPFDAASEVPVEEQRVEAMVRIQDCLVAGQAPQALALLRSAREVWPEGNVFGSPVISPGEEMQLLKQILSATLPRQQEPVEGDAEEEDEEEEEEEEEELQVVQVSEKEFKFLDYLKRFACSTIVRAYVLLLRSYRQNSAHTNHCIAKMLHRLAHDLGMEALLFQLSLFCLFNQLLSDPAAAAYKELVTFAKYILGKFFALAAVNQKAFVELLFWKNTSVVREMTQGYGSLDSGSCSHRAPVWSSEEEAQLQELYLAHKDVEGQDVVETILAHLKAVPRTRKQVIHHLVRMGLADSVKDFQRKGTQIVLWTEDQELELQRLFEEFQDSDDVLGHIMKNITAKRSRARVVDKLLALGLVSERRQLHKKRRKKLAPSCMQNGEESQRDAWQEDPEEEEEKEGLPESEGEENEEDLLAGQVQGSSSLSAENLRQSLCQDGLSAPLLWLQSSLIRAADDREEDGCSQAIPLVPLTEENEEAMENKQFQHLLRKLGIRAPCSGQETFWRIPAKLSSTQLRRVAASLSERENKEEREEEPEPNPGVPGEQSPSEEHQVRAPRALLSARKRKAGLVFPKEEATGEEEWKSVPKKQQLLDSDEEDTDDERGGQAAVSGTLRIHKEKRFLVEDEDEDY
uniprot
proteins
function
FUNCTION: Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (By similarity). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (By similarity). TIMELESS promotes TIPIN nuclear localization (By similarity). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX11 (By similarity). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (By similarity). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (By similarity). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (By similarity). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (By similarity). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (PubMed:10963667). {ECO:0000250|UniProtKB:Q9UNS1, ECO:0000269|PubMed:10963667}.
uniprot
proteins
mass_dalton
138565
uniprot
proteins
protein_family
Timeless family
uniprot
proteins
pubmed
10963667
uniprot
proteins
pubmed
11112428
uniprot
proteins
pubmed
15094047
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11112428}. Chromosome {ECO:0000250|UniProtKB:Q9UNS1}. Note=In response to double-strand breaks (DSBs), accumulates at DNA damage sites via its interaction with PARP1. {ECO:0000250|UniProtKB:Q9UNS1}.
uniprot
proteins