Hmgcs2
entrez
15360
canonical
uniprot
P54869
canonical
ensembl
ENSMUSG00000027875
resolver
ensp
ENSMUSP00000088249
resolver
ensp
ENSMUSP00000113296
resolver
enst
ENSMUST00000090746
resolver
enst
ENSMUST00000120541
resolver
genesymbol
Hmgcs2
resolver
uniprot
Q64740
resolver
uniprot
Q9DBK1
resolver
uniprot
Q9DBM4
resolver
uniprot_entry
HMCS2_MOUSE
resolver
uniprot_sec
Q64740
resolver
uniprot_sec
Q9DBK1
resolver
uniprot_sec
Q9DBM4
resolver
amino_acid_sequence
MQRLLAPARRVLQVKRAMQETSLTPAHLLSAAQQRFSTIPPAPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLVLEQGLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRKKIQNQWKQAGNNQPFTLDDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSSDKQNNLYKGLEAFRGLKLEETYTNKDVDKALLKASLDMFNQKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKRLDSRRRMSPEEFTEIMNQREQFYHKVNFSPPGDTSNLFPGTWYLERVDEMHRRKYARCPV
uniprot
proteins
ec_number
2.3.3.10
uniprot
proteins
function
FUNCTION: Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. {ECO:0000269|PubMed:24315375}.
uniprot
proteins
mass_dalton
56823
uniprot
proteins
mutagenesis
MUTAGEN 83; /note="K->E: Abolishes enzymatic activity."; /evidence="ECO:0000269|PubMed:24315375"; MUTAGEN 310; /note="K->E: Abolishes enzymatic activity."; /evidence="ECO:0000269|PubMed:24315375
uniprot
proteins
pathway_participation
PATHWAY: Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.
uniprot
proteins
post_translational_modification
PTM: Acetylation of Lys-427 is observed in liver mitochondria from fasted mice but not from fed mice.; PTM: Succinylated. Desuccinylated by SIRT5. Succinylation, at least at Lys-83 and Lys-310, inhibits the enzymatic activity. {ECO:0000269|PubMed:24315375}.
uniprot
proteins
protein_family
HMG-CoA synthase family
uniprot
proteins
protein_family
Thiolase-like superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17208939
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24315375
uniprot
proteins
pubmed
7851882
uniprot
proteins
sequence_length
508
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P22791}.
uniprot
proteins