Nr2c1
entrez
252924
canonical
uniprot
Q8VIJ4
canonical
ensembl
ENSRNOG00000006983
resolver
ensembl
ENSRNOG00055005975
resolver
ensembl
ENSRNOG00060004922
resolver
ensembl
ENSRNOG00065012332
resolver
ensp
ENSRNOP00000009578
resolver
ensp
ENSRNOP00000071901
resolver
ensp
ENSRNOP00055007494
resolver
ensp
ENSRNOP00060006182
resolver
ensp
ENSRNOP00065015404
resolver
enst
ENSRNOT00000009578
resolver
enst
ENSRNOT00055009689
resolver
enst
ENSRNOT00060008220
resolver
enst
ENSRNOT00065020082
resolver
genesymbol
Nr2c1
resolver
genesymbol_syn
Tr2
resolver
uniprot_entry
NR2C1_RAT
resolver
amino_acid_sequence
MATIEEIAHQIIDQQMGEIVTEQQTGQKIQIVTALDHSTQGKQFILANHEGSTPGKVFLTTPDAAGVNQLFFASPDLSTPHLQLLTENSPDQGPNKVFDLCVVCGDKASGRHYGAITCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHHRNRCQYCRLQRCIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLAATPTFVTDSETARSTGLLDSGMFVNIHPSGIKTEPALLMTPDKAESCQGDLGTLASVVTSLANLGKAKDLSHCGGDLPVVQSLRNGDTSFGAFHQDIQTNGDVSRAFDNLAKALTPGENPACQSPGESMEGSTHLIAGEPSCMEREGPLLSDSHVVFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHNSLQQDKMSPERRKLLMEHIFKLQEFCNSMVKLCIDGHEYAYLKAIVLFSPDHPGLENMELIEKFQEKAYVEFQDYITRTYPDDTYRLSRLLLRLPALRLMNATITEELFFKGLIGNVRIDSVIPHILKMEPADYNSQIIGHSL
uniprot
proteins
function
FUNCTION: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
65528
uniprot
proteins
post_translational_modification
PTM: Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression (By similarity). {ECO:0000250}.; PTM: Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-210, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-568 by PKC is important for protein stability and function as activator of RARB (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
NR2 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
590
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. Nucleus, PML body {ECO:0000250}. Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-210 phosphorylation, to PML bodies for subsequent sumoylation. {ECO:0000250}.
uniprot
proteins