Ttbk2
entrez
140810
canonical
uniprot
Q3UVR3
canonical
ensembl
ENSMUSG00000090100
resolver
ensp
ENSMUSP00000028740
resolver
ensp
ENSMUSP00000055032
resolver
ensp
ENSMUSP00000083001
resolver
enst
ENSMUST00000028740
resolver
genesymbol
Ttbk2
resolver
genesymbol_syn
Bby
resolver
genesymbol_syn
Kiaa0847
resolver
genesymbol_syn
Ttbk1
resolver
uniprot
A2AW12
resolver
uniprot
A2AW15
resolver
uniprot
Q3TSR6
resolver
uniprot
Q3UFW0
resolver
uniprot
Q571D1
resolver
uniprot
Q8BKA4
resolver
uniprot
Q924U8
resolver
uniprot_entry
A2AW15_MOUSE
resolver
uniprot_entry
TTBK2_MOUSE
resolver
uniprot_sec
A2AW12
resolver
uniprot_sec
Q3TSR6
resolver
uniprot_sec
Q3UFW0
resolver
uniprot_sec
Q571D1
resolver
uniprot_sec
Q8BKA4
resolver
uniprot_sec
Q924U8
resolver
amino_acid_sequence
MSGGGEQPDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGKQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCFMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSTFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKSGTDGSLTTTTTSATPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIPVGVSPDKLPGSLGHPRPQEKDVWEEMDINKNKIKLGICKAATEEENSHGQVNGILNAPSLGSPIRVRSEITQPDRDVPLVRKLRSIHSFELEKRLTLEPKPDTDKFLETCMEKMQKDSSAGKEPVPPALPHKPCVPVVTHTDHIWHYDDEYLPDASKPASANTPEQADGGGSNGFIAVNLSSCKQEVDSKEWVIVDKEQDLQDFRTNEVLGHKTTGSPSDEEPEVLQVLEGSPQDEKIQVGPWTDNHHLKKESSGVVLALSAECPATAASELYTDRLDLQAGAASQFITVTPTSPMEAQAEGPLTAITIPRPSVASTQSTSGSFHYGPQPEKKDLQPLEPTVELYSPRENFSGLVVTEGELASGGSRVDLGLQIDHTGHDMLPNMRDGDTSQDLGPKDPPDHNRLAVKEFEHLPGETEERSLLLGSENEDERLSKGQHCIEVSSPGELVTAERAQLAATEPLHVSETQNCSVLPNQDKTHEIMKLLAVGTSEISPQAIDPHAEGQIGQMAAMQKNKLFKDDGIQSESLPRQQGDLSAFLHQEGKREKVVPRNGELYHCVSENEHGPPTRKDMLRSSFVTRHSRIPVLAQEIDSTFESSSAISAKEKLLQKKAYQPEIVKLLVEKRQFKSFLGDLSSASDKLIEEKLAAVPVPFSEEEVFAPFSRLAADSHLSRSVEDSFLSPIISQARKSKIPRPVSWVSTDQINGSASPQFLPRPPPGKPPVRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKSRSTTQCKSPGSPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSSRRSCQQEHCKPSKNGPKGSGSLHHHSTSSKTPPGKSKPASKLSR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (By similarity). Required for recruitment of CPLANE2 and INTU to the mother centriole (PubMed:29038301). {ECO:0000250|UniProtKB:Q6IQ55, ECO:0000269|PubMed:11257498, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:29038301}.
uniprot
proteins
mass_dalton
136770
uniprot
proteins
mutagenesis
MUTAGEN 163; /note="D->A: Abolishes serine/threonine-protein kinase activity and ability to initiate ciliogenesis."; /evidence="ECO:0000269|PubMed:23141541
uniprot
proteins
protein_family
CK1 Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11257498
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23141541
uniprot
proteins
pubmed
29038301
uniprot
proteins
sequence_length
1243
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:23141541}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:29038301}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:29038301}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6IQ55}. Nucleus {ECO:0000250|UniProtKB:Q6IQ55}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:29038301). May also be present in cytosol and, at lower level in the nucleus (By similarity). {ECO:0000250|UniProtKB:Q6IQ55, ECO:0000269|PubMed:29038301}.
uniprot
proteins