Slc46a1
entrez
303333
canonical
uniprot
Q5EBA8
canonical
ensembl
ENSRNOG00000010291
resolver
ensembl
ENSRNOG00055025814
resolver
ensembl
ENSRNOG00060018987
resolver
ensembl
ENSRNOG00065023418
resolver
ensp
ENSRNOP00000013698
resolver
ensp
ENSRNOP00055036427
resolver
ensp
ENSRNOP00060026824
resolver
ensp
ENSRNOP00065032526
resolver
enst
ENSRNOT00000013698
resolver
enst
ENSRNOT00055044520
resolver
enst
ENSRNOT00060032825
resolver
enst
ENSRNOT00065040019
resolver
genesymbol
Slc46a1
resolver
genesymbol_syn
Hcp1
resolver
genesymbol_syn
Pcft
resolver
uniprot_entry
PCFT_RAT
resolver
activity_regulation
ACTIVITY REGULATION: In contrast to human ortholog, not inhibited by myricetin. {ECO:0000269|PubMed:31792273}.
uniprot
proteins
amino_acid_sequence
MEGRVSPVGSSHRLLTAAVLFRGPVEPLVFLANFALVLQGPLTTQYIWHRISTELGYNGTRHRENCGNQSADPVLKEVETLTSHWTLYMNVGGFLVGLFWSTLLGAWSDRVGRRPLLVLASLGLLLQAVVSIFVVQLQLHIGFFVLGRALCALLGDFNGLLAASFASVADVSSNHSRTFRMALLEACIGVAGTLASLLGGHWLRAQGYANPFWLALAVLIVMTLYAAFCFGETVKEPKSTRLFTLRHHRSIVQLYVVPAPEKSRMHLALYSLAIFVVVTVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLGLRLLQFCLADTWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVTTPVIRAKLSKLVSESEQGALFSAVACVNSLAMLMASGIFNSLYPATLNFMKGFPFLLGAGLLFIPAILIGVLEKVNPHPEFQQFPQNS
uniprot
proteins
function
FUNCTION: Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:18174275, PubMed:31792273). Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (PubMed:18174275). Functions at acidic pH via alternate outward- and inward-open conformation states (By similarity). Protonation of residues in the outward open state primes the protein for transport (By similarity). Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (By similarity). Also able to transport antifolate drugs, such as methotrexate and pemetrexed (PubMed:18174275). Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes (By similarity). Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (By similarity). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (By similarity). Hence, participates in the trafficking of heme and increases intracellular iron content (By similarity). {ECO:0000250|UniProtKB:Q96NT5, ECO:0000269|PubMed:18174275, ECO:0000269|PubMed:31792273}.
uniprot
proteins
mass_dalton
50095
uniprot
proteins
mutagenesis
MUTAGEN 158; /note="N->G: Promotes sensitivity to myricetin inhibitor."; /evidence="ECO:0000269|PubMed:31792273
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
SLC46A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16143108
uniprot
proteins
pubmed
18174275
uniprot
proteins
pubmed
31792273
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96NT5}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q96NT5}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q96NT5}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:Q96NT5}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q6PEM8}. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells (By similarity). Localizes to the basolateral membrane of choroid plexus (By similarity). {ECO:0000250|UniProtKB:Q6PEM8}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..44; /note="Helical; Name=TM1"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 83..108; /note="Helical; Name=TM2"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 113..135; /note="Helical; Name=TM3"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 141..154; /note="Helical; Name=TM4"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 178..203; /note="Helical; Name=TM5"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 209..227; /note="Helical; Name=TM6"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 267..289; /note="Helical; Name=TM7"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 303..325; /note="Helical; Name=TM8"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 332..351; /note="Helical; Name=TM9"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 356..376; /note="Helical; Name=TM10"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 389..414; /note="Helical; Name=TM11"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 423..441; /note="Helical; Name=TM12"; /evidence="ECO:0000250|UniProtKB:F1NJ67
uniprot
proteins