IFI35
entrez
3430
canonical
uniprot
P80217
canonical
ensembl
ENSG00000068079
resolver
ensp
ENSP00000394579
resolver
ensp
ENSP00000395590
resolver
genesymbol
IFI35
resolver
genesymbol_syn
IFP35
resolver
hgnc
HGNC:5399
resolver
uniprot
C9JGX1
resolver
uniprot
Q92984
resolver
uniprot
Q99537
resolver
uniprot
Q9BV98
resolver
uniprot_entry
IN35_HUMAN
resolver
uniprot_sec
C9JGX1
resolver
uniprot_sec
Q92984
resolver
uniprot_sec
Q99537
resolver
uniprot_sec
Q9BV98
resolver
amino_acid_sequence
MSAPLDAALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPFSVPKIPLVFRGHTQQDPEVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPMVTTIQMSSQLSGRRVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGSVMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQKAEIRSQPVPRSVLVLNIPDILDGPELHDVLEIHFQKPTRGGGEVEALTVVPQGQQGLAVFTSESG
uniprot
proteins
function
FUNCTION: Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (PubMed:10779520, PubMed:10950963). In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (PubMed:26342464). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (PubMed:29038465). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465). {ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:29350881}.
uniprot
proteins
mass_dalton
31546
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Dephosphorylation correlates with the formation of a complex with NMI. {ECO:0000269|PubMed:10779520}.
uniprot
proteins
protein_family
NMI family
uniprot
proteins
pubmed
10779520
uniprot
proteins
pubmed
10950963
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
26342464
uniprot
proteins
pubmed
29038465
uniprot
proteins
pubmed
29350881
uniprot
proteins
pubmed
8288566
uniprot
proteins
pubmed
8938427
uniprot
proteins
pubmed
8954125
uniprot
proteins
sequence_length
286
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:8288566}. Nucleus {ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:8288566}. Secreted {ECO:0000269|PubMed:29038465}. Note=Cytoplasmic IFI35 localizes in punctate granular structures (PubMed:10950963). Nuclear localization increased is stimulated by IFN-alpha (PubMed:10950963, PubMed:8288566). Extracellular following secretion by macrophage (PubMed:29038465). {ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:8288566}.
uniprot
proteins