Kcnj10
entrez
29718
canonical
uniprot
P49655
canonical
ensembl
ENSRNOG00000068444
resolver
ensembl
ENSRNOG00055021910
resolver
ensembl
ENSRNOG00060022823
resolver
ensembl
ENSRNOG00065026536
resolver
ensp
ENSRNOP00000079651
resolver
ensp
ENSRNOP00000086322
resolver
ensp
ENSRNOP00000110965
resolver
ensp
ENSRNOP00000111743
resolver
ensp
ENSRNOP00055030661
resolver
ensp
ENSRNOP00060032741
resolver
ensp
ENSRNOP00065037620
resolver
enst
ENSRNOT00000104019
resolver
enst
ENSRNOT00000119639
resolver
enst
ENSRNOT00000131663
resolver
enst
ENSRNOT00000173750
resolver
enst
ENSRNOT00055037599
resolver
enst
ENSRNOT00060039563
resolver
enst
ENSRNOT00065045849
resolver
genesymbol
Kcnj10
resolver
genesymbol_syn
Kab-2
resolver
uniprot
A0A8I6G3K4
resolver
uniprot
A0ABK0LX21
resolver
uniprot
Q62790
resolver
uniprot_entry
A0A8I6G3K4_RAT
resolver
uniprot_entry
A0ABK0LX21_RAT
resolver
uniprot_entry
KCJ10_RAT
resolver
uniprot_sec
Q62790
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is strongly regulated by variations of cytosolic pH; channels are activated by alkaline and inhibited by acidic pH values (PubMed:20807765). Activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2) (PubMed:18690035). Inhibited by Ba(2+) and Cs(+) (PubMed:7608203). {ECO:0000269|PubMed:18690035, ECO:0000269|PubMed:20807765, ECO:0000269|PubMed:7608203}.
uniprot
proteins
amino_acid_sequence
MTSVAKVYYSQTTQTESRPLVAPGIRRRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELGPPANHTPCVVQVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVAYHNGKLCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGDFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYVADFSLFDQVVKVASPGGLRDSTVRYGDPEKLKLEESLREQAEKEGSALSVRISNV
uniprot
proteins
function
FUNCTION: May be responsible for potassium buffering action of glial cells in the brain (PubMed:7608203). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (PubMed:7608203). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (By similarity). {ECO:0000250|UniProtKB:P78508, ECO:0000269|PubMed:7608203}.
uniprot
proteins
mass_dalton
42480
uniprot
proteins
mutagenesis
MUTAGEN 65; /note="R->P: Decreased potassium ion transport. Results in a shift to a more alkaline pH for channel activation."; /evidence="ECO:0000269|PubMed:20807765"; MUTAGEN 67; /note="K->M: Increased activation rate by PtdIns(4,5)P2."; /evidence="ECO:0000269|PubMed:18690035"; MUTAGEN 77; /note="G->R: Loss of potassium ion transport."; /evidence="ECO:0000269|PubMed:20807765"; MUTAGEN 140; /note="C->R: Loss of potassium ion transport."; /evidence="ECO:0000269|PubMed:20807765"; MUTAGEN 164; /note="T->I: Decreased potassium ion transport. Results in a shift to a more alkaline pH for channel activation."; /evidence="ECO:0000269|PubMed:20807765"; MUTAGEN 167; /note="A->V: Decreased potassium ion transport."; /evidence="ECO:0000269|PubMed:20807765"; MUTAGEN 199..379; /note="Missing: Loss of potassium ion transport."; /evidence="ECO:0000269|PubMed:20807765"; MUTAGEN 297; /note="R->C: Loss of potassium ion transport. Results in a shift to a more alkaline pH for channel activation."; /evidence="ECO:0000269|PubMed:20807765
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ10 subfamily
uniprot
proteins
pubmed
18690035
uniprot
proteins
pubmed
20807765
uniprot
proteins
pubmed
38355723
uniprot
proteins
pubmed
7608203
uniprot
proteins
pubmed
7624316
uniprot
proteins
pubmed
7874445
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P78508}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P78508}. Basolateral cell membrane {ECO:0000250|UniProtKB:P78508}. Note=In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16. {ECO:0000250|UniProtKB:P78508}.
uniprot
proteins
transmembrane_region
TRANSMEM 62..88; /note="Helical; Name=M1"; /evidence="ECO:0000269|PubMed:38355723, ECO:0007744|PDB:8I5M"; TRANSMEM 141..166; /note="Helical; Name=M2"; /evidence="ECO:0000269|PubMed:38355723, ECO:0007744|PDB:8I5M
uniprot
proteins