Angpt2
entrez
11601
canonical
uniprot
O35608
canonical
ensembl
ENSMUSG00000031465
resolver
ensp
ENSMUSP00000033846
resolver
enst
ENSMUST00000033846
resolver
genesymbol
Angpt2
resolver
genesymbol_syn
Agpt2
resolver
uniprot
B9EHQ4
resolver
uniprot
Q3U1A1
resolver
uniprot
Q9D2D2
resolver
uniprot_entry
ANGP2_MOUSE
resolver
uniprot_entry
B9EHQ4_MOUSE
resolver
uniprot_sec
Q3U1A1
resolver
uniprot_sec
Q9D2D2
resolver
amino_acid_sequence
MWQIIFLTFGWDLVLASAYSNFRKSVDSTGRRQYQVQNGPCSYTFLLPETDSCRSSSSPYMSNAVQRDAPLDYDDSVQRLQVLENILENNTQWLMKLENYIQDNMKKEMVEIQQNVVQNQTAVMIEIGTSLLNQTAAQTRKLTDVEAQVLNQTTRLELQLLQHSISTNKLEKQILDQTSEINKLQNKNSFLEQKVLDMEGKHSEQLQSMKEQKDELQVLVSKQSSVIDELEKKLVTATVNNSLLQKQQHDLMETVNSLLTMMSSPNSKSSVAIRKEEQTTFRDCAEIFKSGLTTSGIYTLTFPNSTEEIKAYCDMDVGGGGWTVIQHREDGSVDFQRTWKEYKEGFGSPLGEYWLGNEFVSQLTGQHRYVLKIQLKDWEGNEAHSLYDHFYLAGEESNYRIHLTGLTGTAGKISSISQPGSDFSTKDSDNDKCICKCSQMLSGGWWFDACGPSNLNGQYYPQKQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF
uniprot
proteins
function
FUNCTION: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (By similarity). Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 (By similarity). In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression (By similarity). In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). Involved in the regulation of lymphangiogenesis (PubMed:28179430, PubMed:32908006). {ECO:0000250|UniProtKB:O15123, ECO:0000269|PubMed:28179430, ECO:0000269|PubMed:32908006}.
uniprot
proteins
mass_dalton
56576
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
28179430
uniprot
proteins
pubmed
32908006
uniprot
proteins
pubmed
9204896
uniprot
proteins
sequence_length
496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O15123}.
uniprot
proteins