SLC4A5
entrez
57835
canonical
uniprot
Q9BY07
canonical
ensembl
ENSG00000188687
resolver
ensp
ENSP00000366861
resolver
ensp
ENSP00000377587
resolver
genesymbol
SLC4A5
resolver
genesymbol_syn
NBC4
resolver
hgnc
HGNC:18168
resolver
uniprot
Q32MA7
resolver
uniprot
Q59EQ9
resolver
uniprot
Q8WXD3
resolver
uniprot
Q8WXD7
resolver
uniprot
Q96DS7
resolver
uniprot
Q96DS8
resolver
uniprot
Q9HBU5
resolver
uniprot_entry
S4A5_HUMAN
resolver
uniprot_sec
Q32MA7
resolver
uniprot_sec
Q59EQ9
resolver
uniprot_sec
Q8WXD3
resolver
uniprot_sec
Q8WXD7
resolver
uniprot_sec
Q96DS7
resolver
uniprot_sec
Q96DS8
resolver
uniprot_sec
Q9HBU5
resolver
activity_regulation
ACTIVITY REGULATION: Activity is inhibited by 4,4'-di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters). {ECO:0000269|PubMed:26447209}.; ACTIVITY REGULATION: [Isoform 3]: Activity is inhibited by 4,4'-di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters). {ECO:0000269|PubMed:11788353, ECO:0000269|PubMed:11997242}.; ACTIVITY REGULATION: [Isoform 8]: Activity is inhibited by 4,4'-di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters). {ECO:0000269|PubMed:12388414}.
uniprot
proteins
amino_acid_sequence
MKVKEEKAGVGKLDHTNHRRRFPDQKECPPIHIGLPVPTYPQRKTDQKGHLSGLQKVHWGLRPDQPQQELTGPGSGASSQDSSMDLISRTRSPAAEQLQDILGEEDEAPNPTLFTEMDTLQHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKKPIHRSLADIGKSVSTTNRSPARSPGAGPSLHHSTEDLRMRQSANYGRLCHAQSRSMNDISLTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAELGQMNGSVGGGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAPDTVNTTVFNASAPLAPDTNASLYNLLNLTALDWSLLSKKECLSYGGRLLGNSCKFIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACFGLETPKLHVPSVIKPTRPDRGWFVAPFGKNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAPILKCIPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTPFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTVAAIIFPVMILGLIIVRRLLDFIFSQHDLAWIDNILPEKEKKETDKKRKRKKGAHEDCDEEPQFPPPSVIKIPMESVQSDPQNGIHCIARKRSSSWSYSL
uniprot
proteins
function
FUNCTION: Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. {ECO:0000269|PubMed:26447209}.
uniprot
proteins
mass_dalton
126255
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
10978526
uniprot
proteins
pubmed
11087115
uniprot
proteins
pubmed
11788353
uniprot
proteins
pubmed
11997242
uniprot
proteins
pubmed
12063394
uniprot
proteins
pubmed
12388414
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17715183
uniprot
proteins
pubmed
26447209
uniprot
proteins
sequence_length
1137
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:17715183, ECO:0000269|PubMed:26447209}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q6RI88}; Multi-pass membrane protein {ECO:0000255}. Note=Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla. {ECO:0000269|PubMed:17715183}.
uniprot
proteins
transmembrane_region
TRANSMEM 522..544; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 556..587; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 607..628; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 743..762; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 774..795; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 829..847; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 867..883; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 889..908; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 929..948; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 954..971; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1017..1034; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1040..1057; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins