PBK
entrez
55872
canonical
uniprot
Q96KB5
canonical
ensembl
ENSG00000168078
resolver
ensp
ENSP00000301905
resolver
ensp
ENSP00000428489
resolver
ensp
ENSP00000554676
resolver
genesymbol
HEL164
resolver
genesymbol
PBK
resolver
genesymbol_syn
TOPK
resolver
hgnc
HGNC:18282
resolver
uniprot
B4DX68
resolver
uniprot
D3DST2
resolver
uniprot
Q9NPD9
resolver
uniprot
Q9NYL7
resolver
uniprot
Q9NZK6
resolver
uniprot
V9HWH0
resolver
uniprot_entry
TOPK_HUMAN
resolver
uniprot_entry
V9HWH0_HUMAN
resolver
uniprot_sec
B4DX68
resolver
uniprot_sec
D3DST2
resolver
uniprot_sec
Q9NPD9
resolver
uniprot_sec
Q9NYL7
resolver
uniprot_sec
Q9NZK6
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MEGISNFKTPSKLSEKKKSVLCSTPTINIPASPFMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALETDV
uniprot
proteins
ec_number
2.7.12.2
uniprot
proteins
function
FUNCTION: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}.
uniprot
proteins
mass_dalton
36085
uniprot
proteins
mutagenesis
MUTAGEN 9; /note="T->E: TP53-binding."; /evidence="ECO:0000269|PubMed:17482142"; MUTAGEN 64..65; /note="KK->AA: Loss of activity."; /evidence="ECO:0000269|PubMed:10779557"; MUTAGEN 320; /note="T->A: Decrease in the binding to DLG1."; /evidence="ECO:0000269|PubMed:10779557"; MUTAGEN 322; /note="V->A: Decrease in the binding to DLG1."; /evidence="ECO:0000269|PubMed:10779557
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; in a cell-cycle dependent manner at mitosis. {ECO:0000269|PubMed:10779557, ECO:0000269|PubMed:10781613}.
uniprot
proteins
protein_family
MAP kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
10779557
uniprot
proteins
pubmed
10781613
uniprot
proteins
pubmed
11378444
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17482142
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
322
uniprot
proteins