Nfkbia
entrez
25493
canonical
uniprot
Q63746
canonical
ensembl
ENSRNOG00000007390
resolver
ensembl
ENSRNOG00055013559
resolver
ensembl
ENSRNOG00060018781
resolver
ensembl
ENSRNOG00065005143
resolver
ensp
ENSRNOP00000009894
resolver
ensp
ENSRNOP00055018878
resolver
ensp
ENSRNOP00060026378
resolver
ensp
ENSRNOP00065005221
resolver
enst
ENSRNOT00000009894
resolver
enst
ENSRNOT00055023251
resolver
enst
ENSRNOT00060032368
resolver
enst
ENSRNOT00065007544
resolver
genesymbol
Nfkbia
resolver
genesymbol_syn
Ikba
resolver
uniprot
B2RYS5
resolver
uniprot_entry
IKBA_RAT
resolver
uniprot_sec
B2RYS5
resolver
amino_acid_sequence
MFQPAGHGQDWAMEGPRDGLKKERLVDDRHDSGLDSMKDEDYEQMVKELREIRLQPQEAPLAAEPWKQQLTEDGDSFLHLAIIHEEKTLTMEVIGQVKGDLAFLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPELRDFRGNTPLHLACEQGCLASVAVLTQTCTPQHLHSVLQATNYNGHTCLHLASIHGYLGIVEHLVTLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQTLPESEDEESYDTESEFTEDELPYDDCVFGGQRLTL
uniprot
proteins
function
FUNCTION: Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. {ECO:0000250|UniProtKB:P25963}.
uniprot
proteins
mass_dalton
35017
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-32 and Ser-36 by IKKA/CHUK, IKKB/IKBKB and IKKE/IKBKE; disables inhibition of NF-kappa-B DNA-binding activity. Phosphorylation at positions 32 and 36 is prerequisite to recognition by the SCF(FBXW11) and SCF(BTRC) complexes, leading to polyubiquitination and subsequent degradation. {ECO:0000250|UniProtKB:P25963}.; PTM: Polyubiquitinated at Lys-21 and/or Lys-22 following phosphorylation at Ser-32 and Ser-36. Monoubiquitinated at Lys-21 and/or Lys-22 by UBE2D3. Ubiquitin chain elongation is then performed by CDC34 in cooperation with the SCF(FBXW11) E3 ligase complex, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. The resulting polyubiquitination leads to protein degradation. Also ubiquitinated by the SCF(BTRC) complex following stimulus-dependent phosphorylation at Ser-32 and Ser-36. Deubiquitinated by USP38, leading to NF-kappa-B inhibition (By similarity). {ECO:0000250|UniProtKB:P25963}.; PTM: Sumoylated; sumoylation requires the presence of the nuclear import signal. Sumoylation blocks ubiquitination and proteasome-mediated degradation of the protein thereby increasing the protein stability. {ECO:0000250|UniProtKB:P25963}.; PTM: Hydroxylated by HIF1AN. {ECO:0000250|UniProtKB:P25963}.
uniprot
proteins
protein_family
NF-kappa-B inhibitor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1588976
uniprot
proteins
pubmed
1741294
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P25963}. Nucleus {ECO:0000250|UniProtKB:P25963}. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. {ECO:0000250|UniProtKB:P25963}.
uniprot
proteins