Fgl1
entrez
234199
canonical
uniprot
Q71KU9
canonical
ensembl
ENSMUSG00000031594
resolver
ensp
ENSMUSP00000034003
resolver
ensp
ENSMUSP00000271173
resolver
enst
ENSMUST00000034003
resolver
genesymbol
Fgl1
resolver
genesymbol_syn
Mfire1
resolver
uniprot
A0A0R4J0E1
resolver
uniprot
Q8VC25
resolver
uniprot_entry
A0A0R4J0E1_MOUSE
resolver
uniprot_entry
FGL1_MOUSE
resolver
uniprot_sec
Q8VC25
resolver
amino_acid_sequence
MGKIYSFVLVAIALMMGREGWALESESCLREQVRLRAQVHQLETRVKQQQTMIAQLLHEKEVQFLDKGSENSFIDLGGKRQYADCSEIYNDGFKQSGFYKIKPLQSLAEFSVYCDMSDGGGWTVIQRRSDGSENFNRGWNDYENGFGNFVQNNGEYWLGNKNINLLTIQGDYTLKIDLTDFEKNSSFAQYQSFKVGDKKSFYELNIGEYSGTAGDSLSGTFHPEVQWWASHQRMKFSTWDRDNDNYQGNCAEEEQSGWWFNRCHSANLNGVYYRGSYRAETDNGVVWYTWHGWWYSLKSVVMKIRPSDFIPNII
uniprot
proteins
function
FUNCTION: Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a ligand of LAG3 (PubMed:30580966). LAG3-binding initiates a signaling that inhibits the T-cell receptor (TCR) in the immunological synapse, preventing T-cell activation (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (By similarity). {ECO:0000250|UniProtKB:Q08830, ECO:0000269|PubMed:30580966}.
uniprot
proteins
mass_dalton
36439
uniprot
proteins
pubmed
12528893
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23483972
uniprot
proteins
pubmed
30580966
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30580966}. Note=Secreted in the blood plasma. {ECO:0000269|PubMed:30580966}.
uniprot
proteins