Mov10l1
entrez
83456
canonical
uniprot
Q99MV5
canonical
ensembl
ENSMUSG00000015365
resolver
ensp
ENSMUSP00000015509
resolver
ensp
ENSMUSP00000118437
resolver
ensp
ENSMUSP00000334817
resolver
enst
ENSMUST00000015509
resolver
enst
ENSMUST00000146993
resolver
genesymbol
Mov10l1
resolver
genesymbol_syn
Champ
resolver
uniprot
A0A2P1HA42
resolver
uniprot
D3YWG8
resolver
uniprot
G3X8T0
resolver
uniprot
Q7TPA9
resolver
uniprot
Q8C3W0
resolver
uniprot
Q924C2
resolver
uniprot_entry
A0A2P1HA42_MOUSE
resolver
uniprot_entry
D3YWG8_MOUSE
resolver
uniprot_entry
G3X8T0_MOUSE
resolver
uniprot_entry
M10L1_MOUSE
resolver
uniprot_sec
Q7TPA9
resolver
uniprot_sec
Q8C3W0
resolver
uniprot_sec
Q924C2
resolver
amino_acid_sequence
MIDDLIYFSNDAVTSTVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWEDDSKNSSKGLSDSSPRVLIGCVTSMLEGAGYISQTTYFSLESVCEGFHPCKGDWVEAEYWIRPGTWSSEAISVKPLRYKRVDKVCISSLCGRNGVIEDSIFFSLDSLKLPEGYIPRRHDIVNAVVVESSQSCYIWRALCMTPVKRDATLGEAPQEPYGALLLKNKGDIEVTRMTSFGTLKEGESKSIVIWIENKGKFSRELVSCRLANWDKAHQFRFETQGRSKSCPGAAAGSVPEGENVNSLNHHREDKTDEIPESRLANSTEISPDGCACKEESREKGNTPEKQEPEPGGLIPPGEKTHIVVTCSAKNPGRCKELLLLCFSDFLIGRHLEVSVVSSEEALIAVREPFSWKKPKSSQTLVSAKTTVVVTTQKRNSRRQLPSFLPQYPIPDRLKKCVEQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIHAEIELKEYNMSRVVLKRKGDLLVLEVPGLAESRPSLYAGDKLILKSQEYNGHVIEYIGYVMEIHEEDVTLKLNPGFEQMYNFEPMDVEFTYNRTTSRRCHYALEQVIHLGVKVLFPEEIILQSPQVTGNWSLAQDTKNDGQSITNITRNDGQSMTKVTRNDSQSITNIIRNDGQSITNVTRNDGQPITKVTRNNSQSITNITRNDGQPITKNKKTVKDQTKHTTEERHVGTTDQPEKASSTAETMDEIQIPKARDKEFFNPVLNENQKLAVRRILSGDCRPLPYILFGPPGTGKTVTIIEAVLQVHYALPDSRILVCAPSNSAADLVCLRLHESKVPKPAAMVRVNATCRFEETIIDAIKPYCRDGEDIWRASRFRIIITTCSSAGLFYQIGVRVGYFTHVFVDEAGQASEPECLIPLGLISDINGQIVLAGDPMQLGPVIKSRLAMAYGLNVSMLERLMSRPAYLRDENAFGACGAYNPLLVTKLVKNYRSHSALLALPSRLFYHRELEVCADPKVVTSLLGWEKLPRKGFPLIFHGVRGNEAREGRSPSWFSPAEAVQVMRYCCLLARSVSSQVSSKDIGVITPYRKQVEKIKILLRNVDLTDIKVGSVEEFQGQEYLVIVISTVRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLIILGNPHVLVRDPCFGALLEYSVSNGVYTGCDLPPELQALQK
uniprot
proteins
ec_number
5.6.2.5
uniprot
proteins
function
FUNCTION: [Isoform 1]: ATP-dependent 5'-3' RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Involved in the primary piRNA metabolic process (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins (PubMed:25762440). Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins (PubMed:25762440). {ECO:0000269|PubMed:20534472, ECO:0000269|PubMed:20547853, ECO:0000269|PubMed:23166510, ECO:0000269|PubMed:25762440}.; FUNCTION: [Isoform 2]: May act downstream of MEF2C during heart formation. Acts as a cardiac-specific suppressor of cardiomyocyte hypertrophy and cell cycle progression, suggesting that it may suppress these processes through the regulation of CDKN1A. Such results however require additional evidence. {ECO:0000305|PubMed:11854500}.
uniprot
proteins
mass_dalton
132792
uniprot
proteins
mutagenesis
MUTAGEN 778; /note="K->A: Loss of RNA helicase activity. Homozygous knockin male mice are sterile and display meiotic arrest at the zygotene-like stage of prophase I. LINE1 retrotransposons are derepressed and piRNA biogenesis is abolished."; /evidence="ECO:0000269|PubMed:25762440"; MUTAGEN 888..892; /note="DEAGQ->GGAAG: Isoform 2: Abolishes the suppressor of cell proliferation activity."; /evidence="ECO:0000269|PubMed:11854500
uniprot
proteins
protein_family
DNA2/NAM7 helicase family
uniprot
proteins
protein_family
SDE3 subfamily
uniprot
proteins
pubmed
11279525
uniprot
proteins
pubmed
11397016
uniprot
proteins
pubmed
11854500
uniprot
proteins
pubmed
12754203
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20534472
uniprot
proteins
pubmed
20547853
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23166510
uniprot
proteins
pubmed
25762440
uniprot
proteins
sequence_length
1187
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:20534472, ECO:0000269|PubMed:23166510}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (PubMed:20534472, PubMed:23166510). {ECO:0000269|PubMed:23166510, ECO:0000305|PubMed:20534472}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:11854500}.
uniprot
proteins