Phf8
entrez
320595
canonical
uniprot
Q80TJ7
canonical
ensembl
ENSMUSG00000041229
resolver
ensp
ENSMUSP00000040765
resolver
ensp
ENSMUSP00000108281
resolver
ensp
ENSMUSP00000127653
resolver
ensp
ENSMUSP00000182595
resolver
ensp
ENSMUSP00000182596
resolver
ensp
ENSMUSP00000182597
resolver
ensp
ENSMUSP00000182598
resolver
genesymbol
Phf8
resolver
genesymbol_syn
Kiaa1111
resolver
uniprot
A2ABU8
resolver
uniprot
A2ABV0
resolver
uniprot
A2ABV2
resolver
uniprot
A2ABV3
resolver
uniprot
Q8BLX8
resolver
uniprot
Q8BLY0
resolver
uniprot
Q8BZ61
resolver
uniprot
Q8CG26
resolver
uniprot_entry
A2ABV3_MOUSE
resolver
uniprot_entry
PHF8_MOUSE
resolver
uniprot_sec
A2ABU8
resolver
uniprot_sec
A2ABV0
resolver
uniprot_sec
A2ABV2
resolver
uniprot_sec
Q8BLX8
resolver
uniprot_sec
Q8BLY0
resolver
uniprot_sec
Q8BZ61
resolver
uniprot_sec
Q8CG26
resolver
amino_acid_sequence
MASVPVYCLCRLPYDVTRFMIECDMCQDWFHGSCVGVEEEKAADIDLYHCPNCEVLHGPSIMKKRRGSSKGHDNHKGKPLKTGSSMFIRELRGRTFDSSDEVILKPTGSQLTVEFLEENSFSVPILVLKKDGLGMTLPSPSFTVRDVEHYVGSDKEIDVIDVARQADCKMKLGDFVKYYYSGKREKVLNVISLEFSDTRLSNLVETPRIVRKLSWVENLWPEECVFERPNVQKYCLMSVRDSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGDQVEKCYKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFKFPNFETICWYVGKHILDIFRGLRENRRHPASYLVHGGKALNLAFRAWTKKEALPDHEDEIPETVRTVQLIKDLAREIRLVEDIFQQNVGKTSNIFGLQRIFPAGSIPLTKPAHSTSVSMSKLSLPSKNGSKKKGLKPKDIFKKAERKGKQSSALGPAGQLSYNLMDPYSHQALKTGPSQKAKFNMSGTSLNDSDDDSADMDLDGSENPLALLMANGSTKRMKSVSKSRRAKIAKKVDSARLVAEQVMGDEFDLDSDDELQIDERLGKEKANLLIRSKFPRKLPRAKPCSDPNRIREPGEVEFDIEEDYTTDEDMVEGVESKLGNGSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQEAIQGMLCMANLQSSSSSPATSSLQAWWTGGQERSSGSSSSGLGTVSSSPASQRTPGKRPIKRPAYWKNESEEEENASLDEQDSLGACFKDAEYIYPSLESDDDDPALKSRPKKKKNSDDAPWSPKARVTPTLPKQDRPVREGTRVASIETGLAAAAAKLAQQELQKAQKKKYIKKKPLLKEVEQPRPQDSNPIMTMPAPTVATTPQPDTSSSPQPPPEPKQEALSGSLADHEYTARPNAFGMAQANRSTTPMAPGVFLTQRRPSVGSQSSQAGQGKRPKKGLATAKQRLGRILKIHRNGKLLL
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
ec_number
1.14.11.65
uniprot
proteins
function
FUNCTION: Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role in cell cycle progression and rDNA transcription. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Displays a very low intrinsic activity toward dimethylated H3 'Lys-27' (H3K27Me2). May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (By similarity). Required for brain development, probably by regulating expression of neuron-specific genes (By similarity). {ECO:0000250|UniProtKB:P0CH95, ECO:0000250|UniProtKB:Q9UPP1}.
uniprot
proteins
mass_dalton
113553
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-33 and Ser-84 are required for dissociation from chromatin and accumulation of H4K20Me1 levels during prophase. {ECO:0000250|UniProtKB:Q9UPP1}.
uniprot
proteins
protein_family
JHDM1 histone demethylase family
uniprot
proteins
protein_family
JHDM1D subfamily
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15112104
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1023
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UPP1}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9UPP1}. Note=Recruited to H3K4me3 sites on chromatin during interphase. Dissociates from chromatin when cells enter mitosis. {ECO:0000250|UniProtKB:Q9UPP1}.
uniprot
proteins