Nagk
entrez
56174
canonical
uniprot
Q9QZ08
canonical
ensembl
ENSMUSG00000034744
resolver
ensp
ENSMUSP00000042026
resolver
ensp
ENSMUSP00000109482
resolver
enst
ENSMUST00000037376
resolver
enst
ENSMUST00000113851
resolver
genesymbol
Nagk
resolver
genesymbol_syn
Gnk
resolver
uniprot
F6V943
resolver
uniprot
Q3U2G9
resolver
uniprot
Q9D997
resolver
uniprot_entry
F6V943_MOUSE
resolver
uniprot_entry
NAGK_MOUSE
resolver
uniprot_entry
Q3U2G9_MOUSE
resolver
uniprot_entry
Q9D997_MOUSE
resolver
amino_acid_sequence
MAALYGGVEGGGTRSKVLLLSEDGQILAEADGLSTNHWLIGTDQCVERINEMVDRAKQKAGVDPLVPLRSLGLSLSGGEQEDAVRLLIEELRHRFPNLSENYLITTDAAGSIATATPDGGIVLISGTGSNCRLINPDGSESGCGGWGHMMGDEGSAYWIAHQAVKIVFDSIDNLEAAPHDIGHVKQAMFDYFQVPDRLGILTHLYRDFDKCKFAGFCQKIAEGAHQGDPLSRYIFRKAGEMLGRHVVAVLPEIDPVLFQGELGLPILCVGSVWKSWELLKEGFLLALTLGREQQAQNSFSSFTLMKLRHSSALGGASLGARHIGYHLPMDYSINAIAFYSYTF
uniprot
proteins
ec_number
2.7.1.-
uniprot
proteins
ec_number
2.7.1.59
uniprot
proteins
ec_number
2.7.1.60
uniprot
proteins
function
FUNCTION: Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:10824116). Also has N-acetylmannosamine (ManNAc) kinase activity (PubMed:10824116). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (PubMed:22692205). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (PubMed:36002575). {ECO:0000269|PubMed:10824116, ECO:0000269|PubMed:22692205, ECO:0000269|PubMed:36002575}.
uniprot
proteins
mass_dalton
37268
uniprot
proteins
pathway_participation
PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation. {ECO:0000269|PubMed:10824116, ECO:0000269|PubMed:22692205}.
uniprot
proteins
protein_family
Eukaryotic-type N-acetylglucosamine kinase family
uniprot
proteins
pubmed
10824116
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22692205
uniprot
proteins
pubmed
36002575
uniprot
proteins
sequence_length
343
uniprot
proteins