Slc66a1
entrez
362642
canonical
uniprot
B0BMY1
canonical
ensembl
ENSRNOG00000017706
resolver
ensp
ENSRNOP00000023896
resolver
ensp
ENSRNOP00000107028
resolver
enst
ENSRNOT00000023896
resolver
enst
ENSRNOT00000157253
resolver
genesymbol
Slc66a1
resolver
genesymbol_syn
Pqlc2
resolver
uniprot
A0A8L2QDE2
resolver
uniprot
A0ABK0LX84
resolver
uniprot
F7FC79
resolver
uniprot_entry
A0A8L2QDE2_RAT
resolver
uniprot_entry
A0ABK0LX84_RAT
resolver
uniprot_entry
LAAT1_RAT
resolver
uniprot_sec
F7FC79
resolver
amino_acid_sequence
MVWRTLVASNFSTCPNGSIQWIWDVFGECAQDGWDEASVALGLVSIFCFAASTFPQYIKACKTGNMDQALSLWFLLGWIGGDSCNLIGSFLADQLPLQTYTAVYYVLADLLMLTLYFHYKFKKQPSLLSAPINSVLLFILGTVCITPLLSSTDPVAVPREGFRGRTLLSVEPGNKPFTKKEVVGFVIGSASSVLYLLSRLPQIRTNFVRQSTQGISYSLFALVMLGNTLYGLSVLLKNPEVGQSEGSYLLHHLPWLVGSLGVLLLDTIISIQFLVYRSHDADAASEREPLLPS
uniprot
proteins
function
FUNCTION: Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. {ECO:0000269|PubMed:23169667}.
uniprot
proteins
mass_dalton
32232
uniprot
proteins
mutagenesis
MUTAGEN 290..291; /note="LL->AA: Abolishes lysosomal localization."; /evidence="ECO:0000269|PubMed:23169667
uniprot
proteins
protein_family
Laat-1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23169667
uniprot
proteins
sequence_length
293
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:23169667}; Multi-pass membrane protein {ECO:0000269|PubMed:23169667}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 97..117; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 215..235; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins