Q8R4Z1
uniprot
Q8R4Z1
canonical
activity_regulation
ACTIVITY REGULATION: Inhibition of KLK7 is enhanced by heparin. {ECO:0000250|UniProtKB:Q8IW75}.
uniprot
proteins
amino_acid_sequence
MNLVLGLGLFLAGLLTVKGLLQDRDAPDTYESPVRVQEWRGKKDARELTRHNMEFGFKLLQRLASNSRQGNIFLSPLSISTAFSMLSLGAQNSTLEEIREGFNFKEMSDRDMHMGFHYLLQKLNRETQDVKMSIGNALFMDQRLRPQQRFLKLAKNLYDADMILTNFQDLENTQKNINKYISRKTHNRIENMVKNIDPGTVMLLTNYIYFQGRWQYEFDPKQTKEEDFFIEEGKTVKVPMMFQRGMYDMAYDSQLSCTILEMPYRGNITATFVLPDSGKLRLLEQGLQADIFAKWKSLLSKRVVDVWVPRLHISATYNMKKVLSRLGISKIFEEHGDLTRISSHRSLKVGEAVHKAELRMNEKGTEGAAGSGAQTLPMETPRRMKLNAPFLMMIYENLMPSMIFLARIYNP
uniprot
proteins
function
FUNCTION: Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. {ECO:0000250, ECO:0000269|PubMed:16030142}.
uniprot
proteins
mass_dalton
47527
uniprot
proteins
post_translational_modification
PTM: Glycosylation slightly decreases affinity for heparin, but otherwise has no significant effect on KLK7 inhibitory activity or thermal stability of the protein. {ECO:0000250|UniProtKB:Q8IW75}.
uniprot
proteins
protein_family
Serpin family
uniprot
proteins
pubmed
16030142
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q7TMF5}.
uniprot
proteins