SNX2
entrez
6643
canonical
uniprot
O60749
canonical
ensembl
ENSG00000205302
resolver
ensp
ENSP00000368831
resolver
ensp
ENSP00000421663
resolver
genesymbol
SNX2
resolver
hgnc
HGNC:11173
resolver
uniprot
B3KN44
resolver
uniprot
B4DEK4
resolver
uniprot
B7Z408
resolver
uniprot
O43650
resolver
uniprot
P82862
resolver
uniprot
Q53XK8
resolver
uniprot
Q597H6
resolver
uniprot
Q9BTS8
resolver
uniprot_entry
SNX2_HUMAN
resolver
uniprot_sec
B3KN44
resolver
uniprot_sec
B4DEK4
resolver
uniprot_sec
B7Z408
resolver
uniprot_sec
O43650
resolver
uniprot_sec
P82862
resolver
uniprot_sec
Q53XK8
resolver
uniprot_sec
Q597H6
resolver
uniprot_sec
Q9BTS8
resolver
amino_acid_sequence
MAAEREPPPLGDGKPTDFEDLEDGEDLFTSTVSTLESSPSSPEPASLPAEDISANSNGPKPTEVVLDDDREDLFAEATEEVSLDSPEREPILSSEPSPAVTPVTPTTLIAPRIESKSMSAPVIFDRSREEIEEEANGDIFDIEIGVSDPEKVGDGMNAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHVSVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQAKNEIREWEAKVQQGERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIKYWEAFLPEAKAIA
uniprot
proteins
function
FUNCTION: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:20138391, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:23085988, ECO:0000303|PubMed:16179610}.
uniprot
proteins
mass_dalton
58471
uniprot
proteins
mutagenesis
MUTAGEN 182..184; /note="RRF->AAA: Decreases KALRN-dependent lamellipodium formation; no effect on interaction with KALRN."; /evidence="ECO:0000269|PubMed:20604901"; MUTAGEN 211; /note="K->A: Abolishes phosphatidylinositol phosphate binding. Abolishes endosomal location."; /evidence="ECO:0000269|PubMed:16179610"; MUTAGEN 426; /note="K->A: Decreases KALRN-dependent lamellipodium formation; no effect on interaction with KALRN; when associated with A-428."; /evidence="ECO:0000269|PubMed:20604901"; MUTAGEN 428; /note="R->A: Decreases KALRN-dependent lamellipodium formation; no effect on interaction with KALRN; when associated with A-426."; /evidence="ECO:0000269|PubMed:20604901
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
11102511
uniprot
proteins
pubmed
11438682
uniprot
proteins
pubmed
14596906
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16179610
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17101778
uniprot
proteins
pubmed
18088323
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19619496
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19816406
uniprot
proteins
pubmed
19935774
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20138391
uniprot
proteins
pubmed
20604901
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23085988
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
39073202
uniprot
proteins
pubmed
9819414
uniprot
proteins
sequence_length
519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778}; Peripheral membrane protein {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778}; Cytoplasmic side {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778}. Cell projection, lamellipodium {ECO:0000269|PubMed:20604901}. Note=Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalized with F-actin at the leading edge of lamellipodia in cells in a KALRN-dependent manner (PubMed:20604901). {ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:20604901}.
uniprot
proteins