Fech
entrez
14151
canonical
uniprot
P22315
canonical
ensembl
ENSMUSG00000024588
resolver
ensp
ENSMUSP00000025484
resolver
ensp
ENSMUSP00000157791
resolver
enst
ENSMUST00000236586
resolver
genesymbol
Fech
resolver
uniprot
Q4QRK2
resolver
uniprot
Q544X6
resolver
uniprot_entry
HEMH_MOUSE
resolver
uniprot_entry
Q4QRK2_MOUSE
resolver
uniprot_sec
Q544X6
resolver
amino_acid_sequence
MLSASANMAAALRAAGALLREPLVHGSSRACQPWRCQSGAAVAATTEKVHHAKTTKPQAQPERRKPKTGILMLNMGGPETLGEVQDFLQRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKMWTSKQGEGMVKLLDELSPATAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNEVGQKPTMKWSTIDRWPTHPLLIQCFADHILKELNHFPEEKRSEVVILFSAHSLPMSVVNRGDPYPQEVGATVHKVMEKLGYPNPYRLVWQSKVGPVPWLGPQTDEAIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAQKCGAENIRRAESLNGNPLFSKALADLVHSHIQSNKLCSTQLSLNCPLCVNPVCRKTKSFFTSQQL
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Fech are the cause of a viable autosomal recessive mutation (named Fechm1Pas or Fch) that causes jaundice and anemia. {ECO:0000269|PubMed:8325637}.
uniprot
proteins
ec_number
4.98.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the ferrous insertion into protoporphyrin IX. {ECO:0000269|PubMed:27599036}.
uniprot
proteins
mass_dalton
47422
uniprot
proteins
pathway_participation
PATHWAY: Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. {ECO:0000250|UniProtKB:P22830}.
uniprot
proteins
protein_family
Ferrochelatase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
1704134
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20427704
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2246229
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
27599036
uniprot
proteins
pubmed
30366982
uniprot
proteins
pubmed
30765471
uniprot
proteins
pubmed
8276824
uniprot
proteins
pubmed
8325637
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:27599036}; Peripheral membrane protein {ECO:0000269|PubMed:27599036}; Matrix side {ECO:0000269|PubMed:27599036}.
uniprot
proteins