Celf2
entrez
14007
canonical
uniprot
Q9Z0H4
canonical
ensembl
ENSMUSG00000002107
resolver
ensp
ENSMUSP00000002176
resolver
ensp
ENSMUSP00000097996
resolver
ensp
ENSMUSP00000110574
resolver
ensp
ENSMUSP00000110577
resolver
ensp
ENSMUSP00000110584
resolver
ensp
ENSMUSP00000120459
resolver
ensp
ENSMUSP00000130829
resolver
ensp
ENSMUSP00000138297
resolver
ensp
ENSMUSP00000138355
resolver
ensp
ENSMUSP00000138359
resolver
ensp
ENSMUSP00000138764
resolver
ensp
ENSMUSP00000159840
resolver
ensp
ENSMUSP00000205091
resolver
ensp
ENSMUSP00000205092
resolver
ensp
ENSMUSP00000205093
resolver
ensp
ENSMUSP00000205094
resolver
ensp
ENSMUSP00000205095
resolver
ensp
ENSMUSP00000205096
resolver
ensp
ENSMUSP00000205097
resolver
ensp
ENSMUSP00000205098
resolver
enst
ENSMUST00000170438
resolver
enst
ENSMUST00000182879
resolver
enst
ENSMUST00000183209
resolver
enst
ENSMUST00000249661
resolver
genesymbol
Celf2
resolver
genesymbol_syn
Cugbp2
resolver
genesymbol_syn
Napor
resolver
uniprot
A0A0R4J2B0
resolver
uniprot
A0AAA9WVX7
resolver
uniprot
A2AS10
resolver
uniprot
A2AS11
resolver
uniprot
A2AS15
resolver
uniprot
E9QA47
resolver
uniprot
Q3TNX4
resolver
uniprot
Q3TTI4
resolver
uniprot
Q3TUB8
resolver
uniprot
Q3U668
resolver
uniprot
Q3U7J8
resolver
uniprot
Q3U9F2
resolver
uniprot
Q3UVH4
resolver
uniprot
Q9R0B2
resolver
uniprot
Q9Z187
resolver
uniprot
S4R1S7
resolver
uniprot_entry
A0A0R4J2B0_MOUSE
resolver
uniprot_entry
A0AAA9WVX7_MOUSE
resolver
uniprot_entry
CELF2_MOUSE
resolver
uniprot_entry
E9QA47_MOUSE
resolver
uniprot_entry
S4R1S7_MOUSE
resolver
uniprot_sec
A2AS10
resolver
uniprot_sec
A2AS11
resolver
uniprot_sec
A2AS15
resolver
uniprot_sec
Q3TNX4
resolver
uniprot_sec
Q3TTI4
resolver
uniprot_sec
Q3TUB8
resolver
uniprot_sec
Q3U668
resolver
uniprot_sec
Q3U7J8
resolver
uniprot_sec
Q3U9F2
resolver
uniprot_sec
Q3UVH4
resolver
uniprot_sec
Q9R0B2
resolver
uniprot_sec
Q9Z187
resolver
amino_acid_sequence
MRCPKSAVTMRNEELLLSNGTANKMNGALDHSDQPDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQTMEGCSSPIVVKFADTQKDKEQRRLQQQLAQQMQQLNTATWGNLTGLGGLTPQYLALLQQATSSSNLGAFSGIQQMAGMNALQLQNLATLAAAAAAAQTSATSTNANPLSSTSSALGALTSPVAASTPNSTAGAAMNSLTSLGTLQGLAGATVGLNNINALAGMAALNGGLGATGLTNGTAGTMDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSKPY
uniprot
proteins
function
FUNCTION: RNA-binding protein implicated in the regulation of several post-transcriptional events (PubMed:12022233). Involved in pre-mRNA alternative splicing, mRNA translation and stability (PubMed:12022233). Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing (PubMed:12022233). Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle (By similarity). Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB (By similarity). Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs (By similarity). Promotes inclusion of exon 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA (PubMed:12022233). Involved in the apoB RNA editing activity (By similarity). Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (PubMed:12535526). Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5 (By similarity). Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs (By similarity). Binds to apoB mRNA, specifically to AU-rich sequences located immediately upstream of the edited cytidine (By similarity). Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (PubMed:12535526). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (PubMed:12022233). Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis (By similarity). Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (By similarity). {ECO:0000250|UniProtKB:O95319, ECO:0000269|PubMed:12022233, ECO:0000269|PubMed:12535526, ECO:0000269|PubMed:15358864}.
uniprot
proteins
mass_dalton
54271
uniprot
proteins
protein_family
CELF/BRUNOL family
uniprot
proteins
pubmed
10524244
uniprot
proteins
pubmed
11158314
uniprot
proteins
pubmed
12022233
uniprot
proteins
pubmed
12535526
uniprot
proteins
pubmed
15358864
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15830352
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
41223228
uniprot
proteins
pubmed
9887331
uniprot
proteins
sequence_length
508
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12535526, ECO:0000269|PubMed:15830352}. Cytoplasm {ECO:0000269|PubMed:12535526, ECO:0000269|PubMed:15830352}. Note=Colocalizes with APOBEC1 and A1CF (By similarity). RNA-binding activity is detected in both nuclear and cytoplasmic compartments (By similarity). Accumulates in the cytoplasm after ionizing radiation (PubMed:12535526). {ECO:0000250}.
uniprot
proteins