SEMG1
entrez
6406
canonical
uniprot
P04279
canonical
ensembl
ENSG00000124233
resolver
ensp
ENSP00000361867
resolver
genesymbol
SEMG1
resolver
genesymbol_syn
SEMG
resolver
hgnc
HGNC:10742
resolver
uniprot
Q53ZV0
resolver
uniprot
Q53ZV1
resolver
uniprot
Q53ZV2
resolver
uniprot
Q6X4I9
resolver
uniprot
Q6Y809
resolver
uniprot
Q6Y822
resolver
uniprot
Q6Y823
resolver
uniprot
Q86U64
resolver
uniprot
Q96QM3
resolver
uniprot_entry
SEMG1_HUMAN
resolver
uniprot_sec
Q53ZV0
resolver
uniprot_sec
Q53ZV1
resolver
uniprot_sec
Q53ZV2
resolver
uniprot_sec
Q6X4I9
resolver
uniprot_sec
Q6Y809
resolver
uniprot_sec
Q6Y822
resolver
uniprot_sec
Q6Y823
resolver
uniprot_sec
Q86U64
resolver
uniprot_sec
Q96QM3
resolver
amino_acid_sequence
MKPNIIFVLSLLLILEKQAAVMGQKGGSKGRLPSEFSQFPHGQKGQHYSGQKGKQQTESKGSFSIQYTYHVDANDHDQSRKSQQYDLNALHKTTKSQRHLGGSQQLLHNKQEGRDHDKSKGHFHRVVIHHKGGKAHRGTQNPSQDQGNSPSGKGISSQYSNTEERLWVHGLSKEQTSVSGAQKGRKQGGSQSSYVLQTEELVANKQQRETKNSHQNKGHYQNVVEVREEHSSKVQTSLCPAHQDKLQHGSKDIFSTQDELLVYNKNQHQTKNLNQDQQHGRKANKISYQSSSTEERRLHYGENGVQKDVSQSSIYSQTEEKAQGKSQKQITIPSQEQEHSQKANKISYQSSSTEERRLHYGENGVQKDVSQRSIYSQTEKLVAGKSQIQAPNPKQEPWHGENAKGESGQSTNREQDLLSHEQKGRHQHGSHGGLDIVIIEQEDDSDRHLAQHLNNDRNPLFT
uniprot
proteins
function
FUNCTION: Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA. {ECO:0000269|PubMed:19889947}.; FUNCTION: Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone. {ECO:0000269|PubMed:19889947}.
uniprot
proteins
mass_dalton
52131
uniprot
proteins
mutagenesis
MUTAGEN 239; /note="C->G: Abrogates binding to EPPIN and do not inhibit spem motility."; /evidence="ECO:0000269|PubMed:19889947
uniprot
proteins
post_translational_modification
PTM: Transglutaminase substrate.; PTM: Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive release of motile spermatozoa.
uniprot
proteins
protein_family
Semenogelin family
uniprot
proteins
pubmed
10412373
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14562960
uniprot
proteins
pubmed
14629036
uniprot
proteins
pubmed
1517240
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15590901
uniprot
proteins
pubmed
17567961
uniprot
proteins
pubmed
19889947
uniprot
proteins
pubmed
2757795
uniprot
proteins
pubmed
2912989
uniprot
proteins
pubmed
3889920
uniprot
proteins
pubmed
3972122
uniprot
proteins
pubmed
6422553
uniprot
proteins
pubmed
6698208
uniprot
proteins
pubmed
8444163
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins