Ptgds
entrez
25526
canonical
uniprot
P22057
canonical
ensembl
ENSRNOG00000015550
resolver
ensembl
ENSRNOG00055000514
resolver
ensembl
ENSRNOG00060026230
resolver
ensembl
ENSRNOG00065025596
resolver
ensp
ENSRNOP00000020926
resolver
ensp
ENSRNOP00055000704
resolver
ensp
ENSRNOP00060037730
resolver
ensp
ENSRNOP00065036179
resolver
enst
ENSRNOT00000020926
resolver
enst
ENSRNOT00055000890
resolver
enst
ENSRNOT00060045439
resolver
enst
ENSRNOT00065044097
resolver
genesymbol
Ptgds
resolver
uniprot_entry
PTGDS_RAT
resolver
amino_acid_sequence
MAALPMLWTGLVLLGLLGFPQTPAQGHDTVQPNFQQDKFLGRWYSAGLASNSSWFREKKELLFMCQTVVAPSTEGGLNLTSTFLRKNQCETKVMVLQPAGVPGQYTYNSPHWGSFHSLSVVETDYDEYAFLFSKGTKGPGQDFRMATLYSRAQLLKEELKEKFITFSKDQGLTEEDIVFLPQPDKCIQE
uniprot
proteins
ec_number
5.3.99.2
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (PubMed:10387044, PubMed:10650953, PubMed:11058225, PubMed:9188476). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity). Can also, catalyze the conversion of PGH3 (derived from eicosapentaenoate (EPA, C20:5n-3)) to PGD3, though PGH2 remains the preferred substrate (By similarity). {ECO:0000250|UniProtKB:O09114, ECO:0000250|UniProtKB:P41222, ECO:0000269|PubMed:10387044, ECO:0000269|PubMed:10650953, ECO:0000269|PubMed:11058225, ECO:0000269|PubMed:9188476}.
uniprot
proteins
mass_dalton
21301
uniprot
proteins
mutagenesis
MUTAGEN 65; /note="C->A,S: Loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:7836410"; MUTAGEN 89; /note="C->A,S: Disrupts disulfide bond."; /evidence="ECO:0000269|PubMed:7836410"; MUTAGEN 186; /note="C->A,S: Disrupts disulfide bond."; /evidence="ECO:0000269|PubMed:7836410
uniprot
proteins
protein_family
Calycin superfamily
uniprot
proteins
protein_family
Lipocalin family
uniprot
proteins
pubmed
10387044
uniprot
proteins
pubmed
10650953
uniprot
proteins
pubmed
11058225
uniprot
proteins
pubmed
11565799
uniprot
proteins
pubmed
12488457
uniprot
proteins
pubmed
1608945
uniprot
proteins
pubmed
1723819
uniprot
proteins
pubmed
2642896
uniprot
proteins
pubmed
7836410
uniprot
proteins
pubmed
8216319
uniprot
proteins
pubmed
8415655
uniprot
proteins
pubmed
8599604
uniprot
proteins
pubmed
8815894
uniprot
proteins
pubmed
9188476
uniprot
proteins
pubmed
9430563
uniprot
proteins
pubmed
9582446
uniprot
proteins
pubmed
9746734
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Rough endoplasmic reticulum {ECO:0000250|UniProtKB:P41222}. Nucleus membrane {ECO:0000250|UniProtKB:P41222}. Golgi apparatus {ECO:0000250|UniProtKB:P41222}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P41222}. Secreted {ECO:0000250|UniProtKB:P41222}. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted. {ECO:0000250|UniProtKB:P41222}.
uniprot
proteins