SLC25A23
entrez
79085
canonical
uniprot
Q9BV35
canonical
ensembl
ENSG00000125648
resolver
ensp
ENSP00000264088
resolver
ensp
ENSP00000301454
resolver
ensp
ENSP00000618250
resolver
ensp
ENSP00000655284
resolver
ensp
ENSP00000655285
resolver
ensp
ENSP00000655286
resolver
ensp
ENSP00000655287
resolver
ensp
ENSP00000716129
resolver
ensp
ENSP00000716131
resolver
ensp
ENSP00000716133
resolver
ensp
ENSP00000716136
resolver
ensp
ENSP00000716141
resolver
ensp
ENSP00000716142
resolver
ensp
ENSP00000716143
resolver
ensp
ENSP00000716147
resolver
ensp
ENSP00000716149
resolver
ensp
ENSP00000716150
resolver
genesymbol
SLC25A23
resolver
genesymbol_syn
APC2
resolver
genesymbol_syn
MCSC2
resolver
genesymbol_syn
SCAMC3
resolver
hgnc
HGNC:19375
resolver
uniprot
B4DGB6
resolver
uniprot
Q4LBC2
resolver
uniprot
Q705K3
resolver
uniprot
Q86Y43
resolver
uniprot
Q8N2N4
resolver
uniprot
Q96NQ4
resolver
uniprot_entry
SCMC3_HUMAN
resolver
uniprot_sec
B4DGB6
resolver
uniprot_sec
Q4LBC2
resolver
uniprot_sec
Q705K3
resolver
uniprot_sec
Q86Y43
resolver
uniprot_sec
Q8N2N4
resolver
uniprot_sec
Q96NQ4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by an increase in cytosolic calcium levels that induce a conformational change of the N-terminal regulatory domain, uncapping the channel and allowing transport (By similarity). Inhibited by bathophenanthroline, mersalyl, p-hydroxymercuribenzoate, bromcresol purple, tannic acid, pyridoxal 5'-phosphate and p-hydroxymercuribenzoate (PubMed:15123600). {ECO:0000250|UniProtKB:Q6NUK1, ECO:0000269|PubMed:15123600}.
uniprot
proteins
amino_acid_sequence
MRGSPGDAERRQRWGRLFEELDSNKDGRVDVHELRQGLARLGGGNPDPGAQQGISSEGDADPDGGLDLEEFSRYLQEREQRLLLMFHSLDRNQDGHIDVSEIQQSFRALGISISLEQAEKILHSMDRDGTMTIDWQEWRDHFLLHSLENVEDVLYFWKHSTVLDIGECLTVPDEFSKQEKLTGMWWKQLVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNILGGLRSMVLEGGIRSLWRGNGINVLKIAPESAIKFMAYEQIKRAILGQQETLHVQERFVAGSLAGATAQTIIYPMEVLKTRLTLRRTGQYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETLKNWWLQQYSHDSADPGILVLLACGTISSTCGQIASYPLALVRTRMQAQASIEGGPQLSMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMKQALGVTSR
uniprot
proteins
function
FUNCTION: Electroneutral antiporter that mediates the transport of adenine nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenine nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenine nucleotide-dependent metabolic pathways (PubMed:15123600). Also acts as a regulator of mitochondrial calcium uptake and can probably transport trace amounts of other divalent metal cations in complex with ATP (PubMed:24430870, PubMed:28695448). In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides (PubMed:15123600). {ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:24430870, ECO:0000269|PubMed:28695448}.
uniprot
proteins
mass_dalton
52378
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="D->A: Abolishes the ability to regulate mitochondrial calcium uptake; when associated with K-33; A-90 and K-101."; /evidence="ECO:0000269|PubMed:24430870"; MUTAGEN 33; /note="E->K: Abolishes the ability to regulate mitochondrial calcium uptake; when associated with A-22; A-90 and K-101."; /evidence="ECO:0000269|PubMed:24430870"; MUTAGEN 90; /note="D->A: Abolishes the ability to regulate mitochondrial calcium uptake; when associated with A-22; K-33 and K-101."; /evidence="ECO:0000269|PubMed:24430870"; MUTAGEN 101; /note="E->K: Abolishes the ability to regulate mitochondrial calcium uptake; when associated with A-22; K-33 and A-90."; /evidence="ECO:0000269|PubMed:24430870
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15054102
uniprot
proteins
pubmed
15123600
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15716113
uniprot
proteins
pubmed
15801905
uniprot
proteins
pubmed
24430870
uniprot
proteins
pubmed
28695448
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:15054102, ECO:0000305|PubMed:15123600, ECO:0000305|PubMed:15716113}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 189..206; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 244..263; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 287..300; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 337..356; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 380..397; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 437..456; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins