Ascl1
entrez
64186
canonical
uniprot
P19359
canonical
ensembl
ENSRNOG00000085519
resolver
ensembl
ENSRNOG00055020604
resolver
ensembl
ENSRNOG00060023065
resolver
ensembl
ENSRNOG00065022277
resolver
ensp
ENSRNOP00000107713
resolver
ensp
ENSRNOP00055028499
resolver
ensp
ENSRNOP00060032977
resolver
ensp
ENSRNOP00065030720
resolver
enst
ENSRNOT00000162977
resolver
enst
ENSRNOT00055035161
resolver
enst
ENSRNOT00060039908
resolver
enst
ENSRNOT00065037965
resolver
genesymbol
Ascl1
resolver
genesymbol_syn
Ash1
resolver
genesymbol_syn
Mash-1
resolver
uniprot_entry
ASCL1_RAT
resolver
amino_acid_sequence
MESSGKMESGAGQQPQPPQPFLPPAACFFATAAAAAAAAAAAAAQSAQQQQQQQAPQQQAPQLSPVADGQPSGGGHKSAAKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF
uniprot
proteins
function
FUNCTION: Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways (PubMed:10648228). Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach (By similarity). {ECO:0000250|UniProtKB:Q02067, ECO:0000269|PubMed:10648228}.
uniprot
proteins
mass_dalton
24972
uniprot
proteins
pubmed
10648228
uniprot
proteins
pubmed
2392153
uniprot
proteins
sequence_length
233
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02067}.
uniprot
proteins