DPPA3
entrez
359787
canonical
uniprot
Q6W0C5
canonical
ensembl
ENSG00000187569
resolver
ensp
ENSP00000339250
resolver
enst
ENST00000345088
resolver
genesymbol
DPPA3
resolver
genesymbol_syn
STELLAR
resolver
hgnc
HGNC:19199
resolver
uniprot
Q0P5U3
resolver
uniprot
Q6JZS6
resolver
uniprot_entry
DPPA3_HUMAN
resolver
uniprot_sec
Q0P5U3
resolver
uniprot_sec
Q6JZS6
resolver
amino_acid_sequence
MDPSQFNPTYIPGSPQMLTEENSRDDSGASQISSETLIKNLSNLTINASSESVSPLSEALLRRESVGAAVLREIEDEWLYSRRGVRTLLSVQREKMARLRYMLLGGVRTHERRPTNKEPKGVKKESRPFKCPCSFCVSNGWDPSENARIGNQDTKPLQP
uniprot
proteins
function
FUNCTION: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization (PubMed:35314832). In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process (By similarity). Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation (By similarity). Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark (By similarity). Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis (By similarity). May be important for the totipotent/pluripotent states continuing through preimplantation development (By similarity). Also involved in chromatin condensation in oocytogenesis (By similarity). {ECO:0000250|UniProtKB:Q8QZY3, ECO:0000269|PubMed:35314832}.
uniprot
proteins
mass_dalton
17851
uniprot
proteins
pubmed
14654002
uniprot
proteins
pubmed
14684992
uniprot
proteins
pubmed
14990856
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21421998
uniprot
proteins
pubmed
35314832
uniprot
proteins
sequence_length
159
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21421998}. Cytoplasm {ECO:0000269|PubMed:21421998}. Note=Mainly localizes in the female pronucleus, localization to the male pronucleus in much weaker. {ECO:0000250|UniProtKB:Q8QZY3}.
uniprot
proteins