NCBP3
entrez
55421
canonical
uniprot
Q53F19
canonical
ensembl
ENSG00000074356
resolver
ensp
ENSP00000373657
resolver
genesymbol
NCBP3
resolver
genesymbol_syn
C17orf85
resolver
hgnc
HGNC:24612
resolver
uniprot
B3KWG7
resolver
uniprot
Q7L406
resolver
uniprot
Q96FK1
resolver
uniprot
Q9NXZ4
resolver
uniprot_entry
NCBP3_HUMAN
resolver
uniprot_sec
B3KWG7
resolver
uniprot_sec
Q7L406
resolver
uniprot_sec
Q96FK1
resolver
uniprot_sec
Q9NXZ4
resolver
amino_acid_sequence
MAAVRGLRVSVKAEAPAGPALGLPSPEAESGVDRGEPEPMEVEEGELEIVPVRRSLKELIPDTSRRYENKAGSFITGIDVTSKEAIEKKEQRAKRFHFRSEVNLAQRNVALDRDMMKKAIPKVRLETIYICGVDEMSTQDVFSYFKEYPPAHIEWLDDTSCNVVWLDEMTATRALINMSSLPAQDKIRSRDASEDKSAEKRKKDKQEDSSDDDEAEEGEVEDENSSDVELDTLSQVEEESLLRNDLRPANKLAKGNRLFMRFATKDDKKELGAARRSQYYMKYGNPNYGGMKGILSNSWKRRYHSRRIQRDVIKKRALIGDDVGLTSYKHRHSGLVNVPEEPIEEEEEEEEEEEEEEEEDQDMDADDRVVVEYHEELPALKQPRERSASRRSSASSSDSDEMDYDLELKMISTPSPKKSMKMTMYADEVESQLKNIRNSMRADSVSSSNIKNRIGNKLPPEKFADVRHLLDEKRQHSRPRPPVSSTKSDIRQRLGKRPHSPEKAFSSNPVVRREPSSDVHSRLGVPRQDSKGLYADTREKKSGNLWTRLGSAPKTKEKNTKKVDHRAPGAEEDDSELQRAWGALIKEKEQSRQKKSRLDNLPSLQIEVSRESSSGSEAES
uniprot
proteins
function
FUNCTION: Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858). {ECO:0000269|PubMed:26382858}.
uniprot
proteins
mass_dalton
70593
uniprot
proteins
mutagenesis
MUTAGEN 134; /note="D->A: Minor loss of 7-methylguanosine-containing mRNA cap binding."; /evidence="ECO:0000269|PubMed:26382858"; MUTAGEN 155..158; /note="WLDD->ALAA: Complete loss of 7-methylguanosine-containing mRNA cap binding."; /evidence="ECO:0000269|PubMed:26382858
uniprot
proteins
protein_family
NCBP3 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
26382858
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
620
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26382858}. Cytoplasm {ECO:0000269|PubMed:26382858}.
uniprot
proteins