EID1
entrez
23741
canonical
uniprot
Q9Y6B2
canonical
ensembl
ENSG00000255302
resolver
ensp
ENSP00000431162
resolver
genesymbol
EID1
resolver
genesymbol_syn
C15orf3
resolver
genesymbol_syn
CRI1
resolver
genesymbol_syn
RBP21
resolver
hgnc
HGNC:1191
resolver
uniprot
B2RD11
resolver
uniprot
Q8N7I4
resolver
uniprot
Q9BZT9
resolver
uniprot_entry
EID1_HUMAN
resolver
uniprot_sec
B2RD11
resolver
uniprot_sec
Q8N7I4
resolver
uniprot_sec
Q9BZT9
resolver
amino_acid_sequence
MSEMAELSELYEESSDLQMDVMPGEGDLPQMEVGSGSRELSLRPSRSGAQQLEEEGPMEEEEAQPMAAPEGKRSLANGPNAGEQPGQVAGADFESEDEGEEFDDWEDDYDYPEEEQLSGAGYRVSAALEEADKMFLRTREPALDGGFQMHYEKTPFDQLAFIEELFSLMVVNRLTEELGCDEIIDRE
uniprot
proteins
function
FUNCTION: Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms. {ECO:0000269|PubMed:11073989, ECO:0000269|PubMed:11073990}.
uniprot
proteins
mass_dalton
20876
uniprot
proteins
mutagenesis
MUTAGEN 178; /note="L->S: Abolishes RB1 binding."; /evidence="ECO:0000269|PubMed:11223246"; MUTAGEN 180; /note="C->G: Abolishes RB1 binding."; /evidence="ECO:0000269|PubMed:11073990, ECO:0000269|PubMed:11223246"; MUTAGEN 182; /note="E->Q: Abolishes RB1 binding."; /evidence="ECO:0000269|PubMed:11223246
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated in U2OS osteosarcoma cells and is rapidly degraded by proteasome as cells exit the cell cycle exit. {ECO:0000269|PubMed:11073989}.
uniprot
proteins
pubmed
11073989
uniprot
proteins
pubmed
11073990
uniprot
proteins
pubmed
11223246
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15837424
uniprot
proteins
sequence_length
187
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11223246}. Cytoplasm {ECO:0000269|PubMed:11223246}. Note=May shuttle between nucleus and cytoplasm. {ECO:0000250|UniProtKB:Q9DCR4, ECO:0000269|PubMed:11223246}.
uniprot
proteins