Rps27a
entrez
78294
canonical
uniprot
P62983
canonical
ensembl
ENSMUSG00000020460
resolver
ensp
ENSMUSP00000099908
resolver
ensp
ENSMUSP00000099909
resolver
enst
ENSMUST00000102844
resolver
enst
ENSMUST00000102845
resolver
genesymbol
Rps27a
resolver
genesymbol_syn
Uba80
resolver
genesymbol_syn
Ubcep1
resolver
uniprot
P02248
resolver
uniprot
P02249
resolver
uniprot
P02250
resolver
uniprot
P49664
resolver
uniprot
P62991
resolver
uniprot
Q29120
resolver
uniprot
Q62317
resolver
uniprot
Q64223
resolver
uniprot
Q642L7
resolver
uniprot
Q8VCH1
resolver
uniprot
Q91887
resolver
uniprot
Q91888
resolver
uniprot
Q9CXY4
resolver
uniprot
Q9CZM0
resolver
uniprot
Q9D1R5
resolver
uniprot
Q9D2W3
resolver
uniprot
Q9D8D9
resolver
uniprot
Q9ET23
resolver
uniprot
Q9ET24
resolver
uniprot
Q9Z0H9
resolver
uniprot_entry
Q642L7_MOUSE
resolver
uniprot_entry
RS27A_MOUSE
resolver
uniprot_sec
P02248
resolver
uniprot_sec
P02249
resolver
uniprot_sec
P02250
resolver
uniprot_sec
P49664
resolver
uniprot_sec
P62991
resolver
uniprot_sec
Q29120
resolver
uniprot_sec
Q62317
resolver
uniprot_sec
Q64223
resolver
uniprot_sec
Q8VCH1
resolver
uniprot_sec
Q91887
resolver
uniprot_sec
Q91888
resolver
uniprot_sec
Q9CXY4
resolver
uniprot_sec
Q9CZM0
resolver
uniprot_sec
Q9D1R5
resolver
uniprot_sec
Q9D2W3
resolver
uniprot_sec
Q9D8D9
resolver
uniprot_sec
Q9ET23
resolver
uniprot_sec
Q9ET24
resolver
uniprot_sec
Q9Z0H9
resolver
amino_acid_sequence
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMGSHFDRHYCGKCCLTYCFNKPEDK
uniprot
proteins
function
FUNCTION: [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:19754430). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). {ECO:0000250|UniProtKB:P62979, ECO:0000269|PubMed:19754430}.
uniprot
proteins
mass_dalton
17951
uniprot
proteins
post_translational_modification
PTM: [Ubiquitin]: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30. {ECO:0000250|UniProtKB:P62979}.; PTM: [Ubiquitin]: Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones. {ECO:0000250|UniProtKB:P62979}.; PTM: [Small ribosomal subunit protein eS31]: Monoubiquitinated at Lys-107 and Lys-113 by RNF25 in response to ribosome collisions (ribosome stalling): ubiquitination promotes subsequent activation of RNF14, leading to EEF1A1 ubiquitination and degradation and rescue of stalled ribosomes. Deubiquitination at Lys-113 by USP16 is required for maturation of the 40S ribosomal complex. {ECO:0000250|UniProtKB:P62979}.
uniprot
proteins
protein_family
Ubiquitin family; Eukaryotic ribosomal protein eS31 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19754430
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
156
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Ubiquitin]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.; SUBCELLULAR LOCATION: [Small ribosomal subunit protein eS31]: Nucleus, nucleolus {ECO:0000250|UniProtKB:P62979}.
uniprot
proteins