PLEKHG4B
entrez
153478
canonical
uniprot
Q96PX9
canonical
ensembl
ENSG00000153404
resolver
ensp
ENSP00000283426
resolver
ensp
ENSP00000490806
resolver
enst
ENST00000283426
resolver
enst
ENST00000637938
resolver
genesymbol
PLEKHG4B
resolver
genesymbol_syn
KIAA1909
resolver
hgnc
HGNC:29399
resolver
uniprot
A0A1B0GW72
resolver
uniprot
A0AAK2PKJ8
resolver
uniprot_entry
A0AAK2PKJ8_HUMAN
resolver
uniprot_entry
PKH4B_HUMAN
resolver
uniprot_sec
A0A1B0GW72
resolver
amino_acid_sequence
MGFSTADGGGGPGARDLESLDACIQRTLSALYPPFEATAATVLWQLFSVAERCHGGDGLHCLTSFLLPAKRALQHLQQEACARYRGLVFLHPGWPLCAHEKVVVQLASLHGVRLQPGDFYLQVTSAGKQSARLVLKCLSRLGRGTEEVTVPEAMYGCVFTGAFLEWVNRERRHVPLQTCLLTSGLAVHRAPWSDVTDPVFVPSPGAILQSYSSCTGPERLPSSPSEAPVPTQATAGPHFQGSASCPDTLTSPCRRGHTGSDQLRHLPYPERAELGSPRTLSGSSDRDFEKVSPSEQGPRMPPENCGGSGERPDPMDQEDRPKALTFHTDLGIPSSRRRPPGDPTCVQPRRWFRESYMEALRNPMPLGSSEEALGDLACSSLTGASRDLGTGAVASGTQEETSGPRGDPQQTPSLEKERHTPSRTGPGAAGRTLPRRSRSWERAPRSSRGAQAAACHTSHHSAGSRPGGHLGGQAVGTPNCVPVEGPGCTKEEDVLASSACVSTDGGSLHCHNPSGPSDVPARQPHPEQEGWPPGTGDFPSQVPKQVLDVSQELLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLARLRREELGTEDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHLRELASLLEGNDQQSCQKGLQLAKENPQRTEEMVQDFRRGLSAVVSQAECREGELARWTRSSELCETVSSWMGPLDPEACPSSPVAECLRSCHQEATSVAAEAFPGAGVAVLKPHALGKPWASQQDLWLQYPQTRLRLEEALSEAAPDPSLPPLAQSPPKHERAQEAMRRHQKPPSFPSTDSGGGAWEPAQPLSGLPGRALLCGQDGETLRPGLCALWDPLSLLRGLPGAGATTAHLEDSSACSSEPTQTLASRPRKHPQKKMIKKTQSFEIPQPDSGPRDSCQPDHTSVFSKGLEVTSTVATEKKLPLWQHARSPPVTQSRSLSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLRHVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYILQASSAEVKSAWTDVIGRILWRQALKSRELRIQEMASMGIGNQPFMDVKPRDRTPDCAVISDRAPKCAVMSDRVPDSIVKGTESQMRGSTAVSSSDHAAPFKRPHSTISDSSTSSSSSQSSSILGSLGLLVSSSPAHPGLWSPAHSPWSSDIRACVEEDEPEPELETGTQAAVCEGAPAVLLSRTRQA
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. Plays a role in actin cytoskeletal remodeling in the late stage of cell-cell junction formation by regulating the contractility of actin filaments, which prompts the conversion from 'open' to 'closed' junctions. {ECO:0000269|PubMed:32203420, ECO:0000269|PubMed:33310911}.
uniprot
proteins
mass_dalton
178367
uniprot
proteins
mutagenesis
MUTAGEN 1373; /note="K->A,E: Does not localize to the basal membrane nor accumulate at cell-cell junctions in ionomycin-treated cells. Does not affect interaction with ANXA2."; /evidence="ECO:0000269|PubMed:38088892
uniprot
proteins
pubmed
11572484
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
32203420
uniprot
proteins
pubmed
33310911
uniprot
proteins
pubmed
38088892
uniprot
proteins
sequence_length
1627
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basal cell membrane {ECO:0000269|PubMed:33310911, ECO:0000269|PubMed:38088892}. Cell junction {ECO:0000269|PubMed:33310911, ECO:0000269|PubMed:38088892}. Nucleus {ECO:0000269|PubMed:33310911}. Cytoplasm {ECO:0000269|PubMed:33310911}. Note=Located at the basal plane of cell-cell junctions (PubMed:33310911). Intracellular Ca(2+) concentration is a key factor in regulating PLEKHG4B localization; it diffusely distributes in the cytoplasm under low Ca(2+) conditions, localizes to the basal membrane under normal Ca(2+) conditions, and accumulates at the cell-cell junction under higher Ca(2+) conditions (PubMed:38088892). {ECO:0000269|PubMed:33310911, ECO:0000269|PubMed:38088892}.
uniprot
proteins