Id3
entrez
25585
canonical
uniprot
P41138
canonical
ensembl
ENSRNOG00055024330
resolver
ensembl
ENSRNOG00060031798
resolver
ensembl
ENSRNOG00065021910
resolver
ensp
ENSRNOP00055034050
resolver
ensp
ENSRNOP00060045523
resolver
ensp
ENSRNOP00065030098
resolver
enst
ENSRNOT00055041812
resolver
enst
ENSRNOT00060055078
resolver
enst
ENSRNOT00065037295
resolver
genesymbol
Id3
resolver
genesymbol_syn
Id-3
resolver
uniprot_entry
ID3_RAT
resolver
amino_acid_sequence
MKALSPVRGCYEAVCCLSERSLAIARGRGKSPSAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTAELTPELVISKDKRSFCH
uniprot
proteins
function
FUNCTION: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
13059
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in vitro by CDC2 and PKC. {ECO:0000269|PubMed:7864897}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7864897
uniprot
proteins
pubmed
7908517
uniprot
proteins
sequence_length
119
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins