Lin7b
entrez
60377
canonical
uniprot
Q9Z252
canonical
ensembl
ENSRNOG00000020746
resolver
ensp
ENSRNOP00000107896
resolver
enst
ENSRNOT00000165243
resolver
genesymbol
Lin7b
resolver
genesymbol_syn
Mals2
resolver
genesymbol_syn
Veli1a
resolver
genesymbol_syn
Veli2
resolver
uniprot_entry
LIN7B_RAT
resolver
amino_acid_sequence
MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDTLDITGSAEVRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFEKMRSARRRQQHHSYSSLESRG
uniprot
proteins
function
FUNCTION: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O88951, ECO:0000269|PubMed:14960569}.
uniprot
proteins
mass_dalton
22900
uniprot
proteins
protein_family
Lin-7 family
uniprot
proteins
pubmed
10341223
uniprot
proteins
pubmed
10362251
uniprot
proteins
pubmed
12040031
uniprot
proteins
pubmed
12393911
uniprot
proteins
pubmed
14960569
uniprot
proteins
pubmed
15494546
uniprot
proteins
pubmed
9753324
uniprot
proteins
sequence_length
207
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15494546}; Peripheral membrane protein {ECO:0000269|PubMed:15494546}. Basolateral cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction {ECO:0000269|PubMed:15494546}. Postsynaptic density membrane {ECO:0000269|PubMed:15494546}; Peripheral membrane protein {ECO:0000269|PubMed:15494546}. Cell junction, tight junction {ECO:0000269|PubMed:15494546}. Note=Mainly basolateral in renal epithelial cells (By similarity). {ECO:0000250}.
uniprot
proteins