FFAR1
entrez
2864
canonical
uniprot
O14842
canonical
ensembl
ENSG00000126266
resolver
ensp
ENSP00000246553
resolver
ensp
ENSP00000620285
resolver
enst
ENST00000246553
resolver
enst
ENST00000950226
resolver
genesymbol
FFAR1
resolver
genesymbol_syn
GPR40
resolver
hgnc
HGNC:4498
resolver
uniprot
Q0VAS2
resolver
uniprot
Q4VBL4
resolver
uniprot_entry
FFAR1_HUMAN
resolver
uniprot_sec
Q0VAS2
resolver
uniprot_sec
Q4VBL4
resolver
activity_regulation
ACTIVITY REGULATION: The receptor is strongly activated by gamma-linolenic acid, while myristate gives a lower response. It is also activated by phytanic acid and pristanic acid (PubMed:21570468). Is also activated by synthetic agonists, such as TAK-875 (fasiglifam); this compound is a partial agonist and potentiates the activity of the endogenous ligand gamma-linolenic acid (PubMed:24130766). {ECO:0000269|PubMed:21570468, ECO:0000269|PubMed:24130766}.
uniprot
proteins
amino_acid_sequence
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. {ECO:0000250|UniProtKB:Q76JU9, ECO:0000269|PubMed:12496284, ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:23809162, ECO:0000269|PubMed:24130766, ECO:0000269|PubMed:24742677}.
uniprot
proteins
mass_dalton
31457
uniprot
proteins
mutagenesis
MUTAGEN 12; /note="Y->A: Reduces cell surface expression and response to linolenic acid and synthetic agonists."; /evidence="ECO:0000269|PubMed:17699519"; MUTAGEN 44; /note="Y->F: Reduces response to synthetic agonists."; /evidence="ECO:0000269|PubMed:29695780"; MUTAGEN 91; /note="Y->A: Reduces response to linolenic acid. Reduces response to synthetic agonists."; /evidence="ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:25043059"; MUTAGEN 114; /note="Y->F: Reduces response to synthetic agonists."; /evidence="ECO:0000269|PubMed:29695780"; MUTAGEN 123; /note="S->A: Reduces response to synthetic agonists."; /evidence="ECO:0000269|PubMed:29695780"; MUTAGEN 137; /note="H->A: Reduces response to linolenic acid. Reduces response to synthetic agonists."; /evidence="ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:25043059"; MUTAGEN 145; /note="E->A: Constitutive receptor signaling."; /evidence="ECO:0000269|PubMed:19068482"; MUTAGEN 172; /note="E->A: Constitutive receptor signaling."; /evidence="ECO:0000269|PubMed:19068482"; MUTAGEN 183; /note="R->A: Reduces response to linolenic acid. Strongly reduces response to synthetic agonists."; /evidence="ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:25043059"; MUTAGEN 240; /note="Y->A: Reduces response to linolenic acid. Reduces response to synthetic agonists."; /evidence="ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:25043059"; MUTAGEN 244; /note="N->A: Reduces response to linolenic acid. Reduces response to synthetic agonists."; /evidence="ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:25043059"; MUTAGEN 258; /note="R->A: Strongly reduces response to linolenic acid. Strongly reduces response to synthetic agonists."; /evidence="ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:25043059"; MUTAGEN 258; /note="R->K: Reduces response to linolenic acid. Strongly reduces response to synthetic agonists."; /evidence="ECO:0000269|PubMed:17699519
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12496284
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16289108
uniprot
proteins
pubmed
17699519
uniprot
proteins
pubmed
19068482
uniprot
proteins
pubmed
21570468
uniprot
proteins
pubmed
23809162
uniprot
proteins
pubmed
24130766
uniprot
proteins
pubmed
24742677
uniprot
proteins
pubmed
25043059
uniprot
proteins
pubmed
29695780
uniprot
proteins
pubmed
9344866
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:25043059}; Multi-pass membrane protein {ECO:0000269|PubMed:25043059}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..31; /note="Helical; Name=1"; /evidence="ECO:0000255, ECO:0000269|PubMed:25043059"; TRANSMEM 42..64; /note="Helical; Name=2"; /evidence="ECO:0000255, ECO:0000269|PubMed:25043059"; TRANSMEM 80..101; /note="Helical; Name=3"; /evidence="ECO:0000255, ECO:0000269|PubMed:25043059"; TRANSMEM 122..142; /note="Helical; Name=4"; /evidence="ECO:0000255, ECO:0000269|PubMed:25043059"; TRANSMEM 179..200; /note="Helical; Name=5"; /evidence="ECO:0000255, ECO:0000269|PubMed:25043059"; TRANSMEM 224..248; /note="Helical; Name=6"; /evidence="ECO:0000255, ECO:0000269|PubMed:25043059"; TRANSMEM 257..279; /note="Helical; Name=7"; /evidence="ECO:0000255, ECO:0000269|PubMed:25043059
uniprot
proteins