MKNK2
entrez
2872
canonical
uniprot
Q9HBH9
canonical
ensembl
ENSG00000099875
resolver
ensp
ENSP00000250896
resolver
ensp
ENSP00000309485
resolver
genesymbol
MKNK2
resolver
genesymbol_syn
GPRK7
resolver
genesymbol_syn
MNK2
resolver
hgnc
HGNC:7111
resolver
uniprot
B3KS07
resolver
uniprot
Q6GPI3
resolver
uniprot
Q9HBH8
resolver
uniprot
Q9UHR0
resolver
uniprot
Q9Y2N6
resolver
uniprot_entry
B3KS07_HUMAN
resolver
uniprot_entry
MKNK2_HUMAN
resolver
uniprot_sec
Q6GPI3
resolver
uniprot_sec
Q9HBH8
resolver
uniprot_sec
Q9UHR0
resolver
uniprot_sec
Q9Y2N6
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by CGP57380 and staurosporine. Activated by phosphorylation in a negative-feedback regulatory manner in response to chemotherapy (e.g. cytarabine) and thus impairs the generation of antileukemic responses. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:16917500, ECO:0000269|PubMed:20664001, ECO:0000269|PubMed:20722422, ECO:0000269|PubMed:20927323}.
uniprot
proteins
amino_acid_sequence
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}.
uniprot
proteins
mass_dalton
51875
uniprot
proteins
mutagenesis
MUTAGEN 228; /note="D->G: Reduced phosphorylation."; /evidence="ECO:0000269|PubMed:16917500"; MUTAGEN 244; /note="T->A: Loss of kinase activity; when associated with T-249."; /evidence="ECO:0000269|PubMed:11463832"; MUTAGEN 249; /note="T->A: Loss of kinase activity; when associated with T-244."; /evidence="ECO:0000269|PubMed:11463832"; MUTAGEN 379; /note="T->D: Constitutively active."; /evidence="ECO:0000269|PubMed:11463832
uniprot
proteins
post_translational_modification
PTM: Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase. Phosphorylated upon arsenic trioxide As(2)O(3) treatment. Phosphorylated by MAPK1/ERK2, MAPK11 and MAPK14. Dephosphorylated by PP2A. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:18299328}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11013076
uniprot
proteins
pubmed
11154262
uniprot
proteins
pubmed
11463832
uniprot
proteins
pubmed
12897141
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16111636
uniprot
proteins
pubmed
16216586
uniprot
proteins
pubmed
16917500
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17965020
uniprot
proteins
pubmed
18299328
uniprot
proteins
pubmed
18508592
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20664001
uniprot
proteins
pubmed
20722422
uniprot
proteins
pubmed
20823271
uniprot
proteins
pubmed
20927323
uniprot
proteins
pubmed
21149447
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, PML body.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm.
uniprot
proteins