COX6C
entrez
1345
canonical
uniprot
P09669
canonical
ensembl
ENSG00000164919
resolver
ensp
ENSP00000297564
resolver
ensp
ENSP00000428150
resolver
ensp
ENSP00000428702
resolver
ensp
ENSP00000428895
resolver
ensp
ENSP00000428965
resolver
ensp
ENSP00000429410
resolver
ensp
ENSP00000429707
resolver
ensp
ENSP00000429714
resolver
ensp
ENSP00000429755
resolver
ensp
ENSP00000429991
resolver
ensp
ENSP00000567833
resolver
ensp
ENSP00000567834
resolver
ensp
ENSP00000567835
resolver
ensp
ENSP00000567836
resolver
ensp
ENSP00000599026
resolver
ensp
ENSP00000599027
resolver
ensp
ENSP00000599029
resolver
ensp
ENSP00000599030
resolver
ensp
ENSP00000599031
resolver
ensp
ENSP00000599032
resolver
ensp
ENSP00000599033
resolver
ensp
ENSP00000599034
resolver
ensp
ENSP00000599035
resolver
ensp
ENSP00000599036
resolver
ensp
ENSP00000599037
resolver
ensp
ENSP00000636797
resolver
ensp
ENSP00000636798
resolver
ensp
ENSP00000636799
resolver
enst
ENST00000297564
resolver
enst
ENST00000517682
resolver
enst
ENST00000518171
resolver
enst
ENST00000520271
resolver
enst
ENST00000520468
resolver
enst
ENST00000520517
resolver
enst
ENST00000522934
resolver
enst
ENST00000522940
resolver
enst
ENST00000523016
resolver
enst
ENST00000524245
resolver
enst
ENST00000897774
resolver
enst
ENST00000897775
resolver
enst
ENST00000897776
resolver
enst
ENST00000897777
resolver
enst
ENST00000928967
resolver
enst
ENST00000928968
resolver
enst
ENST00000928970
resolver
enst
ENST00000928971
resolver
enst
ENST00000928972
resolver
enst
ENST00000928973
resolver
enst
ENST00000928974
resolver
enst
ENST00000928975
resolver
enst
ENST00000928976
resolver
enst
ENST00000928977
resolver
enst
ENST00000928978
resolver
enst
ENST00000966738
resolver
enst
ENST00000966739
resolver
enst
ENST00000966740
resolver
genesymbol
COX6C
resolver
hgnc
HGNC:2285
resolver
uniprot
A0A024R9B7
resolver
uniprot
B2R4D7
resolver
uniprot_entry
A0A024R9B7_HUMAN
resolver
uniprot_entry
COX6C_HUMAN
resolver
uniprot_sec
B2R4D7
resolver
amino_acid_sequence
MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMKDFEEMRKAGIFQSVK
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P04038}.
uniprot
proteins
mass_dalton
8781
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P04038}.
uniprot
proteins
protein_family
Cytochrome c oxidase subunit 6c family
uniprot
proteins
pubmed
10072584
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19892738
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2849755
uniprot
proteins
pubmed
28844695
uniprot
proteins
pubmed
30030519
uniprot
proteins
sequence_length
75
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Single-pass membrane protein {ECO:0000269|PubMed:30030519}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..54; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P04038
uniprot
proteins