CX3CR1
entrez
1524
canonical
uniprot
P49238
canonical
ensembl
ENSG00000168329
resolver
ensp
ENSP00000351059
resolver
ensp
ENSP00000382166
resolver
ensp
ENSP00000439140
resolver
ensp
ENSP00000444928
resolver
genesymbol
CX3CR1
resolver
genesymbol_syn
CMKBRL1
resolver
genesymbol_syn
GPR13
resolver
hgnc
HGNC:2558
resolver
uniprot
A0N0N6
resolver
uniprot
B2R5Z4
resolver
uniprot
J3KP17
resolver
uniprot_entry
CX3C1_HUMAN
resolver
uniprot_sec
A0N0N6
resolver
uniprot_sec
B2R5Z4
resolver
uniprot_sec
J3KP17
resolver
amino_acid_sequence
MDQFPESVTENFEYDDLAEACYIGDIVVFGTVFLSIFYSVIFAIGLVGNLLVVFALTNSKKPKSVTDIYLLNLALSDLLFVATLPFWTHYLINEKGLHNAMCKFTTAFFFIGFFGSIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAAPQFMFTKQKENECLGDYPEVLQEIWPVLRNVETNFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKAKAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFFPSCDMRKDLRLALSVTETVAFSHCCLNPLIYAFAGEKFRRYLYHLYGKCLAVLCGRSVHVDFSSSESQRSRHGSVLSSNFTYHTSDGDALLLL
uniprot
proteins
disease_involvement
DISEASE: Macular degeneration, age-related, 12 (ARMD12) [MIM:613784]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. {ECO:0000269|PubMed:15208270}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:12055230, PubMed:23125415, PubMed:9390561, PubMed:9782118). CX3CR1-CX3CL1 signaling mediates cell migratory functions (By similarity). Responsible for the recruitment of natural killer (NK) cells to inflamed tissues (By similarity). Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival (By similarity). Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung (By similarity). Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells (By similarity). Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis (PubMed:14581400, PubMed:18971423). Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation (By similarity). Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli (By similarity). Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development (By similarity). Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development (By similarity). Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi (By similarity). Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria (By similarity). Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection (PubMed:29326275). Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (PubMed:20974991). {ECO:0000250|UniProtKB:Q9Z0D9, ECO:0000269|PubMed:12055230, ECO:0000269|PubMed:14581400, ECO:0000269|PubMed:18971423, ECO:0000269|PubMed:20974991, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:29326275, ECO:0000269|PubMed:9390561, ECO:0000269|PubMed:9782118}.; FUNCTION: [Isoform 1]: (Microbial infection) Acts as a coreceptor with CD4 for HIV-1 virus envelope protein. {ECO:0000269|PubMed:14607932, ECO:0000269|PubMed:9726990}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a coreceptor with CD4 for HIV-1 virus envelope protein (PubMed:14607932). May have more potent HIV-1 coreceptothr activity than isoform 1 (PubMed:14607932). {ECO:0000269|PubMed:14607932}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a coreceptor with CD4 for HIV-1 virus envelope protein (PubMed:14607932). May have more potent HIV-1 coreceptor activity than isoform 1 (PubMed:14607932). {ECO:0000269|PubMed:14607932}.
uniprot
proteins
mass_dalton
40396
uniprot
proteins
post_translational_modification
PTM: This protein is not N-glycosylated which is unusual for G protein-coupled receptors. {ECO:0000250|UniProtKB:P35411}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10731151
uniprot
proteins
pubmed
11264153
uniprot
proteins
pubmed
11477410
uniprot
proteins
pubmed
12055230
uniprot
proteins
pubmed
12551893
uniprot
proteins
pubmed
14581400
uniprot
proteins
pubmed
14607932
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15208270
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17909628
uniprot
proteins
pubmed
18971423
uniprot
proteins
pubmed
20974991
uniprot
proteins
pubmed
23125415
uniprot
proteins
pubmed
28791023
uniprot
proteins
pubmed
29326275
uniprot
proteins
pubmed
7590284
uniprot
proteins
pubmed
7646814
uniprot
proteins
pubmed
9390561
uniprot
proteins
pubmed
9726990
uniprot
proteins
pubmed
9782118
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12055230, ECO:0000269|PubMed:28791023, ECO:0000269|PubMed:9390561}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..59; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 70..90; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 104..125; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 143..167; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 196..215; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 232..256; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 274..297; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins