Shtn1
entrez
71653
canonical
uniprot
Q8K2Q9
canonical
ensembl
ENSMUSG00000041362
resolver
ensp
ENSMUSP00000041378
resolver
ensp
ENSMUSP00000126227
resolver
genesymbol
Shtn1
resolver
genesymbol_syn
Kiaa1598
resolver
uniprot
Q5DTW5
resolver
uniprot
Q8C4F6
resolver
uniprot_entry
SHOT1_MOUSE
resolver
uniprot_sec
Q5DTW5
resolver
uniprot_sec
Q8C4F6
resolver
amino_acid_sequence
MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDDDPATDTDAAAETCVSVQCQKQIKELRDQIVSVQEEKKVLAIELENLKSKLGEVMEEVNKVKQEKAVLNSEVLEQRKVLEKCNRVSMLAVEEYEELQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSLPDQQLLKALDENAKLIQQLEEERIQHQKKVKELEERLENEALHKEIHNLRQQLELLEDDKRELEQKYQSSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGNSAKKEKTTQPETAEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKAKPDSLKGSESAVDELKGILGTLNKSTSSRSLKSLGPENSETELERILRRRKLTAEADSSSPTGILATSESKSMPVLGSVSSVTKSALNKKTLEAEFNNPCPLTPEPGEGPRKLEGCTNPKVTFQPPSKGGYRRKCVGSENQAEPVVVLDPVSTHEPQTKDQAAEKDPTQFEEEGGETQPEYKEDSGGKTGETDSSNC
uniprot
proteins
function
FUNCTION: Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth (PubMed:23864681). Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth (By similarity). In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex (PubMed:23864681). Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons (PubMed:23864681). {ECO:0000250|UniProtKB:A0MZ67, ECO:0000269|PubMed:23864681}.
uniprot
proteins
mass_dalton
71343
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-101 and Ser-249 by PAK1 through a CDC42- and RAC1-dependent signaling pathway, which enhances its association with F-actin retrograde flow in filopodia and lamellipodia of axonal growth cones. Phosphorylation on Ser-101 and Ser-249 is increased by netrin-1. {ECO:0000250|UniProtKB:A0MZ67}.
uniprot
proteins
protein_family
Shootin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17030985
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19403918
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23864681
uniprot
proteins
sequence_length
631
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Perikaryon {ECO:0000269|PubMed:23864681}. Cell projection, axon {ECO:0000269|PubMed:23864681}. Cell projection, growth cone {ECO:0000269|PubMed:17030985, ECO:0000269|PubMed:23864681}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23864681}. Cell projection, filopodium {ECO:0000250|UniProtKB:A0MZ67}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:A0MZ67}. Note=Localizes in multiple growth cones at neurite tips before the neuronal symmetry-breaking step. Accumulates in growth cones of a single nascent axon in a neurite length-dependent manner during the neuronal symmetry-breaking step; when absent from the nascent axon's siblings, probably due to competitive transport, prevents the formation of surplus axons. Transported anterogradely from the soma to the axon growth cone in an actin and myosin-dependent manner and passively diffuses back to the cell bodies. Colocalized with L1CAM in close apposition with actin filaments in filopodia and lamellipodia of axonal growth cones in hippocampal neurons. Exhibits retrograde movements in filopodia and lamellopodia of axonal growth cones (By similarity). Colocalized with KIF20B along microtubules to the tip of the growing cone in primary hippocampal neurons (PubMed:23864681). Recruited to the growth cone of developing axon in a KIF20B- and microtubule-dependent manner (PubMed:23864681). {ECO:0000250|UniProtKB:A0MZ67, ECO:0000269|PubMed:23864681}.
uniprot
proteins