Cwf19l2
entrez
244672
canonical
uniprot
Q8BG79
canonical
ensembl
ENSMUSG00000025898
resolver
ensp
ENSMUSP00000027027
resolver
ensp
ENSMUSP00000278731
resolver
genesymbol
Cwf19l2
resolver
uniprot
Q3TIS8
resolver
uniprot
Q3UX04
resolver
uniprot
Q80XN7
resolver
uniprot
Q8BZV5
resolver
uniprot
Q8C0F8
resolver
uniprot_entry
C19L2_MOUSE
resolver
uniprot_sec
Q3TIS8
resolver
uniprot_sec
Q3UX04
resolver
uniprot_sec
Q80XN7
resolver
uniprot_sec
Q8BZV5
resolver
uniprot_sec
Q8C0F8
resolver
amino_acid_sequence
MEAFSVRFESASSIEERKEQTRNARAEVLRQAKHNFEKEQRGEERKRLRDEDTWMLPDVHERIEQFSQEHSEKKKKKKDKHSKKVKKEKKKKRKKQKCQKQSESTDSSASSEDEWVEAAPSQISDKEKTWKVKDKRTEEECDSHDIQRDEWMTIDFMSIKTVSSSSLKAEKETLRQIEREKTQVLEQSKLLERELNPYWKDGGTGLPSKTCILPVTKAKGVEDGGLSWLRKSCQRMKEQAQKENRNFEDIVAEKYGSMEIFQSKLKEAEKIAYKKEDCGWERWRKPTYSDRAQCSQASGTSDLVKCKNLSEDRHLEMEPANSSNYKFSGPDTGKRSGTLQTCRRESALRKNQDSSGNLRSKFLRPSDEDELSFHKRKNFESSSSYSPLVAQASLHCDFRKLTENSEESSASCSRSDRRQENRKPSDKKPLETWSYNANQHSTGGRREQLQAESMSCDPPGRGLQQDMTLTIAGPEAESTYILNVDEKNKLGAKIIKAEMMGNMELAEQLKAQLKEANKFKETQMPAKRLGVEHEDEQEVILIQTDKSGRMWPVSSPRETLDMKAERRKRKRVSTHEDKERVRYFPDDDHLSLKDLVKNEKIGTDINQNRLFMKMASKFMGKSDEDNYTLDDMFVSKAAEKEHLGKKEESQRRRAIAEHQSLAAKMAKCLYCFDSSQFPKHLIVAIGVKVYLCLPSFQSLTEGHCFIVPLQHHQAATVLDEDVWEEIQMFRKSLVKMFEDKELDCIFLETNMGLKKHYHMVYECIPLPKEVGDMAPIYFKKAIMESDEEWSMNKKLIDLSSKDIRKSVPRGLPYFAVDFGLQGGFAHIIEDQYRFPHYFGKEIIGGMLDLEPRLWRKGIRESFEDQRKKSLQFAQWWKPYDITKSKSS
uniprot
proteins
function
FUNCTION: RNA-binding protein which regulates alternative splicing (PubMed:38889293). Recognizes the 5'-GG[A/C][A/G]G[A/C/G]-3' motif with 58% of target sequences containing a 5'-GGCAGA-3' motif (PubMed:38889293). Directly binds and regulates the splicing of genes related to spermatogenesis such as ZNHIT1, BTRC and FBXW7 and is thus required for male fertility (PubMed:38889293). Also has an indirect effect on splicing by acting on the splicing factor RBFOX1 (PubMed:38889293). Required for spliceosome assembly and stability (PubMed:38889293). Required for debranching of intron-derived lariat RNAs (By similarity). {ECO:0000250|UniProtKB:Q2TBE0, ECO:0000269|PubMed:38889293}.
uniprot
proteins
mass_dalton
103173
uniprot
proteins
protein_family
CWF19 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
38889293
uniprot
proteins
sequence_length
887
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:38889293}.
uniprot
proteins