Lrr1
entrez
69706
canonical
uniprot
D3YY91
canonical
ensembl
ENSMUSG00000034883
resolver
ensp
ENSMUSP00000106251
resolver
enst
ENSMUST00000110621
resolver
genesymbol
Lrr1
resolver
uniprot_entry
LLR1_MOUSE
resolver
amino_acid_sequence
MRLPCEVEVRSCHLPTLGLKSRGKGVRAVVSLCQAPGRNELQPEARAEPGGHACLLVSTMKDRQGTSYKLRENIEQLFTKFVDEGKATVRLKEPPVDICLSKANPGNLKTLLSAMRLAHRGCDVNTPLSTLKPVKTSEFEKYKTKMVITSKKDYPLSKNFPYFLEHLQASYCSLARVDMRMLCLKNLTKLDLSHNCIKKLPATIGDLTHLQELNLNDNQLETFSVPLCTSTLQKSLHSLDLSKNKIKALPVQFCQFRELTNLNLNDNELIHLPFKIGQLTNLRFLSAARNKLRNLPSEFKMLSLEYLDLFGNTFEKPEVIPIIKLQVPLTLLESCEQAVLFYRIPYGPDIIPYHLCQDLDTAKTCVCGRFCLQSFIQGTTTMNLHSVAHTVVLVDSMGRTEAPVVSYFCSLTCFVKSSDMLN
uniprot
proteins
function
FUNCTION: Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:33590678). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (PubMed:33590678). May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1 (By similarity). {ECO:0000250|UniProtKB:Q96L50, ECO:0000269|PubMed:33590678}.
uniprot
proteins
mass_dalton
47514
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:33590678}.
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
33590678
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:33590678}.
uniprot
proteins