PSMB4
entrez
5692
canonical
uniprot
P28070
canonical
ensembl
ENSG00000159377
resolver
ensp
ENSP00000290541
resolver
enst
ENST00000290541
resolver
genesymbol
PSMB4
resolver
genesymbol_syn
PROS26
resolver
hgnc
HGNC:9541
resolver
uniprot
A0A140VK46
resolver
uniprot
B2R9L3
resolver
uniprot
P31148
resolver
uniprot
Q5SZS5
resolver
uniprot
Q6IBI4
resolver
uniprot
Q969L6
resolver
uniprot_entry
A0A140VK46_HUMAN
resolver
uniprot_entry
PSB4_HUMAN
resolver
uniprot_sec
B2R9L3
resolver
uniprot_sec
P31148
resolver
uniprot_sec
Q5SZS5
resolver
uniprot_sec
Q6IBI4
resolver
uniprot_sec
Q969L6
resolver
amino_acid_sequence
MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEKGVEIEGPLSTETNWDIAHMISGFE
uniprot
proteins
disease_involvement
DISEASE: Proteasome-associated autoinflammatory syndrome 3 (PRAAS3) [MIM:617591]: An autoinflammatory disorder characterized by onset in early infancy and recurrent fever, nodular dermatitis, myositis, panniculitis-induced lipodystrophy, lymphadenopathy, and immune dysregulation. Variable accompanying features may include joint contractures, hepatosplenomegaly, anemia, thrombocytopenia, recurrent infections, autoantibodies, and hypergammaglobulinemia. Some patients may have intracranial calcifications. PRAAS3 inheritance is autosomal recessive or digenic. {ECO:0000269|PubMed:26524591}. Note=The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. {ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
uniprot
proteins
mass_dalton
29204
uniprot
proteins
protein_family
Peptidase T1B family
uniprot
proteins
pubmed
11571290
uniprot
proteins
pubmed
12097147
uniprot
proteins
pubmed
12181345
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
14550573
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15244466
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15660529
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
17367606
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
2306472
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23495936
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25599644
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26133119
uniprot
proteins
pubmed
26524591
uniprot
proteins
pubmed
26829627
uniprot
proteins
pubmed
27176742
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
27493187
uniprot
proteins
pubmed
34711951
uniprot
proteins
pubmed
7811265
uniprot
proteins
pubmed
7918633
uniprot
proteins
pubmed
8013624
uniprot
proteins
pubmed
8610016
uniprot
proteins
pubmed
8692272
uniprot
proteins
pubmed
9344905
uniprot
proteins
sequence_length
264
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
uniprot
proteins