Plekhf2
entrez
71801
canonical
uniprot
Q91WB4
canonical
ensembl
ENSMUSG00000049969
resolver
ensp
ENSMUSP00000054745
resolver
enst
ENSMUST00000054776
resolver
genesymbol
Plekhf2
resolver
uniprot_entry
PKHF2_MOUSE
resolver
amino_acid_sequence
MVDRLANSEANTRRISIVESCFGAAGQPLTIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLENVTIDSIKDEGELRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCVTDLLSKSGKTPSNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPSQSSKPVRICDFCYDLLSTGDMAACQPTRSDSYSQSLKSPLNDASDDDDDDDSSD
uniprot
proteins
function
FUNCTION: May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport (By similarity). Enhances cellular sensitivity to TNF-induced apoptosis. {ECO:0000250, ECO:0000269|PubMed:18288467}.
uniprot
proteins
mass_dalton
27755
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18288467
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:Q9H8W4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H8W4}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9H8W4}. Note=Colocalizes with EEA1 and RAB5 at endosomal membrane fusion hot spots. May translocate to the endoplasmic reticulum in the early phase of apoptosis. {ECO:0000250|UniProtKB:Q9H8W4}.
uniprot
proteins