Srrm3
entrez
58212
canonical
uniprot
Q80WV7
canonical
ensembl
ENSMUSG00000039860
resolver
ensp
ENSMUSP00000013615
resolver
ensp
ENSMUSP00000115695
resolver
ensp
ENSMUSP00000304152
resolver
enst
ENSMUST00000013615
resolver
genesymbol
Srrm3
resolver
uniprot
H7BWX3
resolver
uniprot
Q9CUV5
resolver
uniprot
Q9JJ91
resolver
uniprot_entry
H7BWX3_MOUSE
resolver
uniprot_entry
SRRM3_MOUSE
resolver
uniprot_sec
Q9CUV5
resolver
uniprot_sec
Q9JJ91
resolver
amino_acid_sequence
MSSTVNNGATGMPAPPDAANGFPQPGASSGSWPRAEEELRAAEPGLVKRAHREILDHERKRRVELKCMELQEMMEEQGYSEEEIRQKVGTFRQMLMEKEGVLTREDRPGAHIVAETPRRMEGLEPGLEYPPFDEDDGPVDCDCPVSCYRGHRGYRTKHWSSSSASPPPKKKKKKKGSHRRSRKKRRLESECSCGSASPLRKKKKNVKKHRRDRSDSGSRRKRRYRSRSLKSKRKEKNKERKRPHTESPGRRFHHHSSASSHSPSMSSHYSDSGSPSRLSPKHRDDGRKTGSQRSSGSRSPSPSGGSGWGSPQQNGGSRQRSGAHGGRPGSAHSPPDKPSSPRACDKAAAAPTPPARGKDSQSPRSAPSSQGRGGRAAGGTARRRRRRRRRRRSRSSANAPRRRGRRRTKPAPPRGSSRSLSGAHSSSDSGGGAPGPGPEPCSERGHGGHGKRAKERPPRARPASTSPSPGTRGRRGGPEGNSSSRSPGPHQGSWSSSRSPSKSHSRSPDKRTRSPSLSPSPKKPLGRDKDSEGRARHAEAEAARTRRRSRSYSPIRKRRRDSPSFMEPRRITSARKRPIPYYRPSPSSSSSCLSTDYSSRSHSRSPSPGHSHGSYSSRSHGTRSRSCSASRSRSPSYHSRSSSESGGF
uniprot
proteins
function
FUNCTION: RNA splicing factor that regulates the inclusion of microexons in mRNA transcripts (PubMed:30995482, PubMed:36759540, PubMed:30602030). Required for motor coordination. In cortical neurons, acts redundantly with SRRM4 and regulates many alternative splicing events, including inclusion of exon 4 into the transcriptional repressor REST transcript, leading to REST inactivation. REST inactivation de-represses potassium-chloride cotransporter 2/SLC12A5 expression, resulting in the switch in GABAergic neurotransmission from immature excitatory to inhibitory (PubMed:30995482). Regulates inclusion of a microexon in TBC1D24 in the brain cortex (PubMed:30602030). In pancreatic islets, mediates microexon inclusion and regulates glucose- or amino acid-stimulated insulin secretion, as well as glucagon secretion (PubMed:36759540). Important for islet morphogenesis during pancreas development (PubMed:36759540). Regulates microexon inclusion in the developing retina, which is required for outer segment maintenance and vision (PubMed:35858306). {ECO:0000269|PubMed:30602030, ECO:0000269|PubMed:30995482, ECO:0000269|PubMed:35858306, ECO:0000269|PubMed:36759540}.
uniprot
proteins
mass_dalton
71104
uniprot
proteins
protein_family
CWC21 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
30602030
uniprot
proteins
pubmed
30995482
uniprot
proteins
pubmed
35858306
uniprot
proteins
pubmed
36759540
uniprot
proteins
sequence_length
648
uniprot
proteins