Cckbr
entrez
12426
canonical
uniprot
P56481
canonical
ensembl
ENSMUSG00000030898
resolver
ensp
ENSMUSP00000033189
resolver
ensp
ENSMUSP00000209785
resolver
enst
ENSMUST00000033189
resolver
genesymbol
Cckbr
resolver
uniprot
Q3ZB46
resolver
uniprot_entry
GASR_MOUSE
resolver
uniprot_entry
Q3ZB46_MOUSE
resolver
amino_acid_sequence
MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGLISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCYVQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANTWRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG
uniprot
proteins
function
FUNCTION: Receptor for the peptide hormones gastrin and cholecystokinin (CCK). Expressed throughout the central nervous system, where it modulates processes such as anxiety, analgesia, arousal and neuroleptic activity. Couples to both GNAI1 and GNAQ signaling pathways, but not to GNAS (By similarity). Upon gastrin activation, reduces glucose absorption in intestinal epithelial cells by down-regulating SGLT1 and GLUT2 expression through suppression of the PI3K/Akt/eIF4B pathway (PubMed:39950948). In the kidney, decreases SGLT2 expression under high-glucose conditions via ERK/NF-kappa-B signaling (PubMed:39721589). {ECO:0000250|UniProtKB:P32239, ECO:0000269|PubMed:39721589, ECO:0000269|PubMed:39950948}.
uniprot
proteins
mass_dalton
49172
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10860839
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
39721589
uniprot
proteins
pubmed
39950948
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P32239}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P32239}.
uniprot
proteins
transmembrane_region
TRANSMEM 56..79; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P32239"; TRANSMEM 88..109; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P32239"; TRANSMEM 129..149; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P32239"; TRANSMEM 172..189; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P32239"; TRANSMEM 218..243; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P32239"; TRANSMEM 340..359; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P32239"; TRANSMEM 380..398; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P32239
uniprot
proteins