CORO1C
entrez
23603
canonical
uniprot
Q9ULV4
canonical
ensembl
ENSG00000110880
resolver
ensp
ENSP00000261401
resolver
ensp
ENSP00000394496
resolver
ensp
ENSP00000438341
resolver
genesymbol
CORO1C
resolver
genesymbol_syn
CRN2
resolver
genesymbol_syn
CRNN4
resolver
hgnc
HGNC:2254
resolver
uniprot
A7MAP0
resolver
uniprot
A7MAP1
resolver
uniprot
B3KU12
resolver
uniprot
Q9NSK5
resolver
uniprot_entry
COR1C_HUMAN
resolver
uniprot_sec
A7MAP0
resolver
uniprot_sec
A7MAP1
resolver
uniprot_sec
B3KU12
resolver
uniprot_sec
Q9NSK5
resolver
amino_acid_sequence
MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRMSERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDDLYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKCDLISIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKLEQQMAKIAA
uniprot
proteins
function
FUNCTION: Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). Interacts with GDP-bound RAB44 in bone marrow macrophages to promote osteoclastogenesis (By similarity). Involved in the migration and chemotaxis of macrophages (By similarity). {ECO:0000250|UniProtKB:Q9WUM4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:30220460, ECO:0000269|PubMed:34106209}.; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. {ECO:0000269|PubMed:19651142}.
uniprot
proteins
mass_dalton
53249
uniprot
proteins
protein_family
WD repeat coronin family
uniprot
proteins
pubmed
10828594
uniprot
proteins
pubmed
12377779
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19651142
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22364218
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25074804
uniprot
proteins
pubmed
25925950
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30220460
uniprot
proteins
pubmed
34106209
uniprot
proteins
sequence_length
474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12377779, ECO:0000269|PubMed:19651142, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950}; Peripheral membrane protein {ECO:0000269|PubMed:19651142, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950}; Cytoplasmic side {ECO:0000269|PubMed:19651142, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950}. Cell projection, lamellipodium {ECO:0000269|PubMed:12377779, ECO:0000269|PubMed:19651142}. Cell projection, ruffle membrane {ECO:0000269|PubMed:25074804}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10828594, ECO:0000269|PubMed:12377779, ECO:0000269|PubMed:19651142, ECO:0000269|PubMed:25074804}. Cytoplasm, cell cortex {ECO:0000269|PubMed:10828594, ECO:0000269|PubMed:19651142}. Endosome membrane {ECO:0000269|PubMed:30220460}. Note=All isoforms colocalize with the actin cytoskeleton in the cytosol, and especially in the cell cortex (PubMed:10828594, PubMed:19651142, PubMed:25074804). Colocalizes with F-actin at the leading edge of lamellipodia. Partially colocalizes with microtubules and vimentin intermediate filaments (PubMed:10828594, PubMed:19651142, PubMed:25074804). Localizes to endosome membrane tubules/buds (PubMed:30220460). {ECO:0000269|PubMed:10828594, ECO:0000269|PubMed:19651142, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:30220460}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane, sarcolemma {ECO:0000269|PubMed:19651142}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:19651142}. Synapse {ECO:0000269|PubMed:19651142}. Cell membrane {ECO:0000269|PubMed:19651142}; Peripheral membrane protein {ECO:0000269|PubMed:19651142}; Cytoplasmic side {ECO:0000269|PubMed:19651142}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19651142}. Cytoplasm, cell cortex {ECO:0000269|PubMed:19651142}. Note=Colocalizes with the thin filaments of the sarcomere and with the postsynaptic area and the junctional sarcoplasm of motor end plates. Colocalizes with the actin cytoskeleton in the cytosol, and especially in the cell cortex. {ECO:0000269|PubMed:19651142}.
uniprot
proteins