Macrod1
entrez
107227
canonical
uniprot
Q922B1
canonical
ensembl
ENSMUSG00000036278
resolver
ensp
ENSMUSP00000039507
resolver
ensp
ENSMUSP00000309441
resolver
ensp
ENSMUSP00000309442
resolver
ensp
ENSMUSP00000309443
resolver
ensp
ENSMUSP00000309449
resolver
ensp
ENSMUSP00000309456
resolver
enst
ENSMUST00000040261
resolver
genesymbol
Macrod1
resolver
genesymbol_syn
Lrp16
resolver
uniprot_entry
MACD1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Subject to competitive inhibition by the product ADP-ribose. {ECO:0000250|UniProtKB:Q9BQ69}.
uniprot
proteins
amino_acid_sequence
MSLQSQVSGRLAQLRAAGQLLVSLRPWPGRSAGGPRPRGSACGPLVALGEHGYCAWLSAGVGAWGAAGRGAWVRTWAPLAMAAKVDLSTSTDWKEAKSFLKGLSDKQREEHYFCKDFIKLKKIPTWKETAKGLAVKVEDPKYKKDKQLNEKISLYRGDITKLEVDAIVNAANSSLLGGGGVDGCIHRAAGSLLTDECRTLQNCETGKAKITCGYRLPAKYVIHTVGPIAVGQPTASQAAELRSCYLSSLDLLLEHRLRSVAFPCISTGVFGYPNEEAAEVVLASLREWLEQHKDKVDRLIICVFLEKDEGIYRERLPHYFPVA
uniprot
proteins
ec_number
3.1.1.106
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
function
FUNCTION: Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. {ECO:0000250|UniProtKB:Q9BQ69}.
uniprot
proteins
mass_dalton
35295
uniprot
proteins
protein_family
MacroD-type family
uniprot
proteins
protein_family
MacroD1/2-like subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BQ69}. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. {ECO:0000250|UniProtKB:Q9BQ69}.
uniprot
proteins