Lyar
entrez
17089
canonical
uniprot
Q08288
canonical
ensembl
ENSMUSG00000067367
resolver
ensp
ENSMUSP00000084791
resolver
ensp
ENSMUSP00000109741
resolver
ensp
ENSMUSP00000268581
resolver
ensp
ENSMUSP00000268587
resolver
ensp
ENSMUSP00000268592
resolver
ensp
ENSMUSP00000341758
resolver
ensp
ENSMUSP00000356019
resolver
ensp
ENSMUSP00000356020
resolver
ensp
ENSMUSP00000356021
resolver
enst
ENSMUST00000087514
resolver
enst
ENSMUST00000114106
resolver
genesymbol
Lyar
resolver
uniprot
Q9D9X2
resolver
uniprot_entry
LYAR_MOUSE
resolver
uniprot_sec
Q9D9X2
resolver
amino_acid_sequence
MVFFTCNACGESVKKIQVEKHVSNCRNCECLSCIDCGKDFWGDDYKSHVKCISEGQKYGGKGYEAKTHKGDAKQQAWIQKINELIKKPNVSPKVRELLQQISAFDNVPRKKAKFQNWMKNSLKVHSDSVLEQVWDIFSEASSSEQDQQQPPSHTAKPHAEMPITKVPSAKTNGTTEEQTEAKKNKRERKEERQKNRKKEKKELKLENHQENLRGQKPKKRKKNQEAGHEAAGEEAAEASGPPEKKKAQGGQASEEGADRNGGPGEDAAEGQTKTAAGKRKRPKHSGAESGYKKKKMKLPEQPEEGEAKDHEAPSKGKFNWKGTIKAVLKQAPDNEISVKKLKKKVIAQYHAVMNDHHTSEEELLAIFNRKISRNPTFKVLKDRVKLLK
uniprot
proteins
function
FUNCTION: Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity). Also acts at the level of transcription regulation. Along with PRMT5, binds embryonic globin promoter (By similarity). Represses the expression of embryonic globin Hbb-y gene (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and that encoding the small nucleolar RNA SNORD41 (By similarity). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (By similarity). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (By similarity). In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (By similarity). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (PubMed:25735755). Prevents NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (PubMed:19489080). {ECO:0000250|UniProtKB:Q9NX58, ECO:0000269|PubMed:19489080, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:25735755}.
uniprot
proteins
mass_dalton
43736
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19489080
uniprot
proteins
pubmed
20339383
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23212345
uniprot
proteins
pubmed
24990247
uniprot
proteins
pubmed
25092918
uniprot
proteins
pubmed
25735755
uniprot
proteins
pubmed
8491376
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:19489080, ECO:0000269|PubMed:23212345, ECO:0000269|PubMed:24990247, ECO:0000269|PubMed:8491376}. Cytoplasm {ECO:0000269|PubMed:24990247}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:25735755}. Note=Component of pre-ribosomal particles, including pre-40S, pre-60S and pre-90S (By similarity). Associated with cytoplasmic ribosomes, but not polysomes, as a component of the 60S subunit (PubMed:24990247). In the retina, predominantly expressed in photoreceptor outer segments (PubMed:25735755). In the nucleolus, colocalizes with nucleolin/NCL, therefore may reside in the dense fibrillar component (DFC) (PubMed:19489080). {ECO:0000250|UniProtKB:Q9NX58, ECO:0000269|PubMed:19489080, ECO:0000269|PubMed:24990247, ECO:0000269|PubMed:25735755}.
uniprot
proteins