Dhfr
entrez
24312
canonical
uniprot
Q920D2
canonical
ensembl
ENSRNOG00000082925
resolver
ensp
ENSRNOP00000109261
resolver
enst
ENSRNOT00000164530
resolver
genesymbol
Dhfr
resolver
uniprot
B0BMV8
resolver
uniprot_entry
B0BMV8_RAT
resolver
uniprot_entry
DYR_RAT
resolver
amino_acid_sequence
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD
uniprot
proteins
ec_number
1.5.1.3
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of 7,8-dihydrofolate (DHF) to 5,6,7,8-tetrahydrofolate in a NADPH-dependent manner. Key enzyme in folate metabolism (PubMed:25980602). Contributes to the nuclear and mitochondrial de novo thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2 (By similarity). {ECO:0000250|UniProtKB:P00374, ECO:0000269|PubMed:25980602}.
uniprot
proteins
mass_dalton
21638
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1. {ECO:0000250|UniProtKB:P00374}.
uniprot
proteins
post_translational_modification
PTM: Sumoylated by UBE2I/UBC9. {ECO:0000250|UniProtKB:P00374}.
uniprot
proteins
protein_family
Dihydrofolate reductase family
uniprot
proteins
pubmed
11502523
uniprot
proteins
pubmed
25980602
uniprot
proteins
sequence_length
187
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25980602}. Cytoplasm {ECO:0000269|PubMed:25980602}. Nucleus {ECO:0000250|UniProtKB:P00374}. Note=Localized to the nucleus during S and G2/M phases of the cell cycle. As a component of the de novo thymidylate synthesis complex, localizes specifically to replication forks during DNA synthesis (By similarity). {ECO:0000250|UniProtKB:P00374}.
uniprot
proteins