Cd3d
entrez
12500
canonical
uniprot
P04235
canonical
ensembl
ENSMUSG00000032094
resolver
ensp
ENSMUSP00000034602
resolver
ensp
ENSMUSP00000355536
resolver
enst
ENSMUST00000034602
resolver
genesymbol
Cd3d
resolver
genesymbol_syn
CD3d
resolver
genesymbol_syn
T3d
resolver
uniprot
Q3U4T1
resolver
uniprot
Q3V3B4
resolver
uniprot
Q6P5P1
resolver
uniprot_entry
CD3D_MOUSE
resolver
uniprot_entry
Q3U4T1_MOUSE
resolver
uniprot_entry
Q3V3B4_MOUSE
resolver
uniprot_entry
Q6P5P1_MOUSE
resolver
amino_acid_sequence
MEHSGILASLILIAVLPQGSPFKIQVTEYEDKVFVTCNTSVMHLDGTVEGWFAKNKTLNLGKGVLDPRGIYLCNGTEQLAKVVSSVQVHYRMCQNCVELDSGTMAGVIFIDLIATLLLALGVYCFAGHETGRPSGAAEVQALLKNEQLYQPLRDREDTQYSRLGGNWPRNKKS
uniprot
proteins
function
FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly (PubMed:10935641). Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells. {ECO:0000250|UniProtKB:P04234, ECO:0000269|PubMed:10935641}.
uniprot
proteins
mass_dalton
19032
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. {ECO:0000250|UniProtKB:P04234}.
uniprot
proteins
pubmed
10935641
uniprot
proteins
pubmed
15459203
uniprot
proteins
pubmed
2827170
uniprot
proteins
pubmed
2939461
uniprot
proteins
sequence_length
173
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 106..126; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins