MRGPRE
entrez
116534
canonical
uniprot
Q86SM8
canonical
ensembl
ENSG00000184350
resolver
ensp
ENSP00000374482
resolver
enst
ENST00000389832
resolver
genesymbol
MRGPRE
resolver
genesymbol_syn
GPR167
resolver
genesymbol_syn
MRGE
resolver
hgnc
HGNC:30694
resolver
uniprot
Q2M1V7
resolver
uniprot_entry
MRGRE_HUMAN
resolver
uniprot_sec
Q2M1V7
resolver
amino_acid_sequence
MMEPREAGQHVGAANGAQEDVAFNLIILSLTEGLGLGGLLGNGAVLWLLSSNVYRNPFAIYLLDVACADLIFLGCHMVAIVPDLLQGRLDFPGFVQTSLATLRFFCYIVGLSLLAAVSVEQCLAALFPAWYSCRRPRHLTTCVCALTWALCLLLHLLLSGACTQFFGEPSRHLCRTLWLVAAVLLALLCCTMCGASLMLLLRVERGPQRPPPRGFPGLILLTVLLFLFCGLPFGIYWLSRNLLWYIPHYFYHFSFLMAAVHCAAKPVVYFCLGSAQGRRLPLRLVLQRALGDEAELGAVRETSRRGLVDIAA
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for L-tryptophanocholate (Trp-CA), an amino-acid-conjugated bile acid produced by the microbiome, which regulates glucose homeostasis (PubMed:40446798). Expressed in enteroendocrine L cells of the gut epithelium: Trp-CA binding causes a conformation change that triggers signaling via G(s) G protein, mediating activation of adenylate cyclase activity (PubMed:40446798). In addition to G(s), MRGPRE also associates with beta-arrestin-1 (ARRB1), promoting phosphorylation of ALDOA (PubMed:40446798). Both G(s) and beta-arrestin-1 signaling pathways improves glucose tolerance by enhancing GLP-1 secretion (PubMed:40446798). {ECO:0000269|PubMed:40446798}.
uniprot
proteins
mass_dalton
34286
uniprot
proteins
mutagenesis
MUTAGEN 99; /note="L->A: Decreased G(s)-mediated signaling in response to Trp-CA."; /evidence="ECO:0000269|PubMed:40446798"; MUTAGEN 103; /note="R->A: Decreased G(s)-mediated signaling in response to Trp-CA. Abolished Trp-CA-induced GLP-1 secretion."; /evidence="ECO:0000269|PubMed:40446798"; MUTAGEN 107; /note="Y->A: Decreased G(s)-mediated signaling in response to Trp-CA. Abolished Trp-CA-induced GLP-1 secretion."; /evidence="ECO:0000269|PubMed:40446798"; MUTAGEN 232; /note="P->A: Decreased G(s)-mediated signaling in response to Trp-CA."; /evidence="ECO:0000269|PubMed:40446798"; MUTAGEN 233; /note="F->A: Decreased G(s)-mediated signaling in response to Trp-CA."; /evidence="ECO:0000269|PubMed:40446798"; MUTAGEN 251; /note="Y->A: Decreased G(s)-mediated signaling in response to Trp-CA."; /evidence="ECO:0000269|PubMed:40446798"; MUTAGEN 261; /note="H->A: Decreased G(s)-mediated signaling in response to Trp-CA."; /evidence="ECO:0000269|PubMed:40446798
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Mas subfamily
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
40446798
uniprot
proteins
sequence_length
312
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:40446798}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 60..80; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 107..127; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 218..238; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 242..262; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins