ACR
entrez
49
canonical
uniprot
P10323
canonical
ensembl
ENSG00000100312
resolver
ensembl
ENSG00000291368
resolver
ensp
ENSP00000216139
resolver
ensp
ENSP00000516837
resolver
enst
ENST00000216139
resolver
enst
ENST00000707314
resolver
genesymbol
ACR
resolver
genesymbol_syn
ACRS
resolver
hgnc
HGNC:126
resolver
uniprot
Q6ICK2
resolver
uniprot_entry
ACRO_HUMAN
resolver
uniprot_sec
Q6ICK2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by SERPINA5. {ECO:0000269|PubMed:7521127}.
uniprot
proteins
amino_acid_sequence
MVEMLPTAILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSNALRMIQSATPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPAAQPRPPPSPPPPPPPPASPLPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLKGKTYSDGKNHYDMETTELPELTSTS
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 87 (SPGF87) [MIM:620500]: An autosomal recessive male infertility disorder characterized by inability of mutant sperm to penetrate the zona pellucida, resulting in fertilization failure. {ECO:0000269|PubMed:37004249}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.21.10
uniprot
proteins
function
FUNCTION: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. {ECO:0000269|PubMed:37004249}.
uniprot
proteins
mass_dalton
45847
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
11839395
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
1628652
uniprot
proteins
pubmed
2114285
uniprot
proteins
pubmed
2298447
uniprot
proteins
pubmed
2493394
uniprot
proteins
pubmed
37004249
uniprot
proteins
pubmed
7521127
uniprot
proteins
sequence_length
421
uniprot
proteins