Chfr
entrez
231600
canonical
uniprot
Q810L3
canonical
ensembl
ENSMUSG00000014668
resolver
ensp
ENSMUSP00000014812
resolver
ensp
ENSMUSP00000108138
resolver
ensp
ENSMUSP00000143480
resolver
genesymbol
Chfr
resolver
uniprot
Q3TFD8
resolver
uniprot
Q3U233
resolver
uniprot
Q3U4U9
resolver
uniprot
Q3UGJ9
resolver
uniprot
Q8BJZ9
resolver
uniprot
Q8BWH4
resolver
uniprot_entry
CHFR_MOUSE
resolver
uniprot_sec
Q3TFD8
resolver
uniprot_sec
Q3U233
resolver
uniprot_sec
Q3U4U9
resolver
uniprot_sec
Q3UGJ9
resolver
uniprot_sec
Q8BJZ9
resolver
uniprot_sec
Q8BWH4
resolver
amino_acid_sequence
MELHGEEQPPPPQEPWGRLLRLGAEEDEPQILLWKREWTIGRRRGCDLSFPSNKLVSGDHCKLTVDEISGEVTLEDTSTNGTVINKLQVVKKQTYPLQSGDIIYLVYRKNEPEHNVAYLYESLSGKQSLTQDSLEANKENMFHVTKDCSGPGQGDDPQVPLLSPMAQTCLEEPQPSTSTSDLLPTASTSSTEPELTSAGQKHSSSSGPGNTSISPKGRSSLVANGELSSLSPVFQDKEASFSLLESKDHEELEPAKKKMKGDGELDTNLQLLVSGQRGNAQTSSEDVKDASVKPDKMEETLTCIICQDLLHDCVSLQPCMHTFCAACYSGWMERSSLCPTCRCPVERICKNHILNNLVEAYLIQHPDKSRSEEDVRSMDARNKITQDMLQPKVRRSFSDEEGSSEDLLELSDVDSESSDISQPYIVCRQCPEYRRQAVQSLPCPVPESELGATLALGGEAPSTSASLPTAAPDYMCPLQGSHAICTCCFQPMPDRRAEREQDPRVAPQQCAVCLQPFCHLYWGCTRTGCFGCLAPFCELNLGDKCLDGVLNNNNYESDILKNYLATRGLTWKSVLTESLLALQRGVFMLSDYRITGNTVLCYCCGLRSFRELTYQYRQNIPASELPVTVTSRPDCYWGRNCRTQVKAHHAMKFNHICEQTRFKN
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity). {ECO:0000250|UniProtKB:Q96EP1, ECO:0000269|PubMed:15793587}.
uniprot
proteins
mass_dalton
73871
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Poly-ADP-ribosylated. In addition to binding non covalently poly(ADP-ribose) via its PBZ-type zinc finger, the protein is also covalently poly-ADP-ribosylated by PARP1. {ECO:0000250|UniProtKB:Q96EP1}.; PTM: Autoubiquitinated; may regulate its cellular level. {ECO:0000250|UniProtKB:Q96EP1}.; PTM: Phosphorylated by PKB. Phosphorylation may affect its E3 ligase activity. {ECO:0000250|UniProtKB:Q96EP1}.
uniprot
proteins
protein_family
CHFR family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15793587
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17525332
uniprot
proteins
sequence_length
664
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, PML body {ECO:0000250|UniProtKB:Q96EP1}.
uniprot
proteins