Dlg4
entrez
13385
canonical
uniprot
Q62108
canonical
ensembl
ENSMUSG00000020886
resolver
ensp
ENSMUSP00000018700
resolver
ensp
ENSMUSP00000104229
resolver
ensp
ENSMUSP00000155942
resolver
ensp
ENSMUSP00000155973
resolver
ensp
ENSMUSP00000156059
resolver
ensp
ENSMUSP00000156345
resolver
ensp
ENSMUSP00000232933
resolver
ensp
ENSMUSP00000232934
resolver
enst
ENSMUST00000018700
resolver
enst
ENSMUST00000231452
resolver
enst
ENSMUST00000231506
resolver
enst
ENSMUST00000231628
resolver
genesymbol
Dlg4
resolver
genesymbol_syn
Dlgh4
resolver
genesymbol_syn
Psd95
resolver
uniprot
A0A338P6E5
resolver
uniprot
A0A338P6I6
resolver
uniprot
Q5NCV5
resolver
uniprot
Q5NCV6
resolver
uniprot
Q5NCV7
resolver
uniprot
Q91WJ1
resolver
uniprot_entry
A0A338P6E5_MOUSE
resolver
uniprot_entry
A0A338P6I6_MOUSE
resolver
uniprot_entry
DLG4_MOUSE
resolver
uniprot_sec
Q5NCV5
resolver
uniprot_sec
Q5NCV6
resolver
uniprot_sec
Q5NCV7
resolver
uniprot_sec
Q91WJ1
resolver
amino_acid_sequence
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKIIEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFHFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL
uniprot
proteins
function
FUNCTION: Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins (PubMed:15358775, PubMed:9853749). Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (Probable). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (By similarity). {ECO:0000250|UniProtKB:P78352, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:9853749, ECO:0000305|PubMed:26931375, ECO:0000305|PubMed:29199957}.
uniprot
proteins
mass_dalton
80472
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Palmitoylation is required for targeting to postsynaptic density, plasma membrane and synapses. Palmitoylation by ZDHHC2 occurs when the synaptic activity decreases and induces DLG4 synaptic clustering. Palmitoylation by ZDHHC15 regulates trafficking to the postsynaptic density and function in synaptogenesis. Palmitoylation may play a role in glutamate receptor GRIA1 synapse clustering. Depalmitoylated by ABHD17A and ABHD17B and to a lesser extent by ABHD17C, ABHD12, ABHD13, LYPLA1 and LYPLA2. Undergoes rapid synaptic palmitoylation/depalmitoylation cycles during neuronal development which slow down in mature neurons. {ECO:0000250|UniProtKB:P31016}.; PTM: Ubiquitinated by MDM2 in response to NMDA receptor activation, leading to proteasome-mediated degradation of DLG4 which is required for AMPA receptor endocytosis. {ECO:0000250|UniProtKB:P31016}.
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
11134026
uniprot
proteins
pubmed
11483650
uniprot
proteins
pubmed
11997254
uniprot
proteins
pubmed
14988405
uniprot
proteins
pubmed
15358775
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
16828986
uniprot
proteins
pubmed
16980967
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18164504
uniprot
proteins
pubmed
19243221
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19474308
uniprot
proteins
pubmed
20089912
uniprot
proteins
pubmed
20178993
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24069373
uniprot
proteins
pubmed
24153177
uniprot
proteins
pubmed
25979765
uniprot
proteins
pubmed
26931375
uniprot
proteins
pubmed
28334377
uniprot
proteins
pubmed
29199957
uniprot
proteins
pubmed
31651360
uniprot
proteins
pubmed
33981040
uniprot
proteins
pubmed
37261953
uniprot
proteins
pubmed
38233523
uniprot
proteins
pubmed
38452102
uniprot
proteins
pubmed
9853749
uniprot
proteins
sequence_length
724
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P31016}; Lipid-anchor {ECO:0000250|UniProtKB:P31016}; Cytoplasmic side {ECO:0000250|UniProtKB:P31016}. Postsynaptic density {ECO:0000269|PubMed:26931375, ECO:0000269|PubMed:29199957, ECO:0000269|PubMed:31651360}. Synapse {ECO:0000269|PubMed:24153177}. Cytoplasm {ECO:0000250|UniProtKB:P31016}. Cell projection, axon {ECO:0000250|UniProtKB:P31016}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P31016}. Cell projection, dendrite {ECO:0000250|UniProtKB:P31016}. Presynapse {ECO:0000250|UniProtKB:P31016}. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Suppression of neuronal activity induces synaptic accumulation and clustering of DLG4. {ECO:0000250|UniProtKB:P31016}.
uniprot
proteins