Mroh1
entrez
223658
canonical
uniprot
E0CZ22
canonical
ensembl
ENSMUSG00000022558
resolver
ensp
ENSMUSP00000090256
resolver
ensp
ENSMUSP00000094115
resolver
ensp
ENSMUSP00000268897
resolver
ensp
ENSMUSP00000268898
resolver
ensp
ENSMUSP00000268912
resolver
genesymbol
Mroh1
resolver
genesymbol_syn
Kiaa1833
resolver
uniprot
D3Z624
resolver
uniprot
E0CYC5
resolver
uniprot
Q80T84
resolver
uniprot_entry
MROH1_MOUSE
resolver
uniprot_sec
D3Z624
resolver
uniprot_sec
E0CYC5
resolver
uniprot_sec
Q80T84
resolver
amino_acid_sequence
MTRPYIKRLSFTLLDSITDKDPMVQEQVCSALCSLGDAQPDETLHACEEYLRQHDKLAHPYRTKILRAMETVLSSHIHDLDKDTAGAVILLATSEMTRTKELDCDWQQAAGSVLVAVGKRFTNQVMEEVLSRFQPGMLPHSSVLHTLANLSVSNAFDMVPFLPSILSTMLPMLSMAKQDALKVVFCGALQHFSESILEYLANLDQAPDPTVRKDTFGADIFGAYDVLFHHWLQSRDAKLRLAVVAALGPMSHLLPSERLEEQLPKLLPAVLGLYKKHAEAFQISKSLGQILEAAVNVSSRTLEVQLDALLVALHAQICVPVESSSPLVMNSQKEVLRCFTVLACCSPDRLLAFLLPRLDTSNERLRVGTLQILRHIINSAAAQMEAKQPFILSSMRLPLLDTNDKVKRAVVQVISAMAHHGYLEQPGGEVMVEYIVQQCALPAEEPEKPGPDGEDLAADSVRAVSIRTLYLVSTTVDRMNSVLWPYLLEFLTPVRFTAALTPLCRSLVHLALKRQEAGADDFLIQYNANANLPSPFAMTTRLLVVSSNPYLGDGRGAASLRLLKVMHQNIHPFLGQRWETTMPMLLEYLDEHTEESLSLKEWEEKLLMFLRDTLAVVSDNIWICQLSQEMCKQLPSYSGTPQEKNFLYKCIGTTLGAASSKEVVRKHLRELLETARYQEEAEQEGLACCFGICAITHLEDTLAQLEDFVRSDVFRKSTGIFSIFKDRSEHEVERMKSCLILCYGHVAAQAPRELVLARVESDILRSMFQCFNTKVLGIKVETKDPALKLCLVQSLCMVSQAMCSSAQASSFHFLRKTELVTQMMEFIRAEPPDCLRTPIRKKAMLACTYLVNLEPALEEQTQADVVHSCLHSVMALPPEAEGGDGVGREPLYLDTVCALEDLLTRLLRQNMTPQGLQIMVEHLSPWIKSPRGHERARALGLGACLLEFFQEHLLVSTLVPFHNLGLLVGLFAPRCADTWTTTRQKAVGCVYSLLYLQLGYEGFSRDHRDDVAERLLTLQDGLVNADPTILFHTCHSIAQVIAKRLPSDQLISLLLTVFESLGDPDKNCSRAATVMINCLLKERGNVLLEKVPEIVSVLRAKLRDTQEEHVLPAAQHSVYLLASQHCEAVVSSLLGSPLPFDSHTCALWRALAVEPGLTAQVLELLLEKMSKDVPFKESRAFLLGSTADRVATLLPLAATCALYEVLSAPSSGTVVLELYPQLFAALLLRVSCTVGVQLPRNLQAKERRSTSPARAARNLDPCSSAVDALQALLLRSGSQDMLRCVELERGWELLKTSAGHEDGVAQLASSMAKYAGPRLPPVTKALACTQNSVYEIQRVTSTAFLAELLSSNVVNDLMLLEPLLDNLTARLKDSSASVRRLVLRGLANMASGSPDKVRAHGPQLLTAMVSGLDDGDEPHSPVALEAMVGLSRLLDLVEPWDLRLVLLHTTIRIRPFFDSEKVEFRTASIRLFGHLNKACHGDCEDVFLEQVVGGLVPLLLHLRDPQVPVASACKFALCMCVPHLECAELAAAFYKYLQEGRSVHFGEFLNSTCKHLMHHFPDLLGRLVSTNLFYFKSSWDDVRAAAPMFTGFLVLHAEPEQKTQVDLEQLIVALQLLLKDPVPGVREKAAETLGRLVKFA
uniprot
proteins
function
FUNCTION: Lysosome fission factor. Recruited to lysosomes by RAB7 (RAB7A or RAB7B) at scission sites and homooligomerizes to mediate the constriction and scission of lysosomal tubules. May sever membranes by inserting amphipathic helices into one bilayer leaflet. Lysosome fission is required to maintain their steady-state number, shape, size, composition and function, and to accomplish regeneration. {ECO:0000250|UniProtKB:Q8NDA8}.
uniprot
proteins
mass_dalton
181795
uniprot
proteins
protein_family
MROH1 family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
1640
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q8NDA8}. Note=Recruited to the lysosome membrane by RAB7 (RAB7A or RAB7B). {ECO:0000250|UniProtKB:Q8NDA8}.
uniprot
proteins