Slc6a13
entrez
14412
canonical
uniprot
P31649
canonical
ensembl
ENSMUSG00000030108
resolver
ensp
ENSMUSP00000066779
resolver
ensp
ENSMUSP00000167351
resolver
ensp
ENSMUSP00000364464
resolver
enst
ENSMUST00000064580
resolver
genesymbol
Slc6a13
resolver
genesymbol_syn
Gabt2
resolver
genesymbol_syn
Gabt3
resolver
genesymbol_syn
Gat-3
resolver
genesymbol_syn
Gat2
resolver
genesymbol_syn
Gat3
resolver
uniprot
Q8CF74
resolver
uniprot_entry
Q8CF74_MOUSE
resolver
uniprot_entry
S6A13_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Gamma-aminobutyric acid (GABA) transport is inhibited by beta-alanine, taurine, hypotaurine, beta-guanidinopropionic acid, 2,3-diaminopropionic acid, guvacine and nipecotic acid (PubMed:22896705, PubMed:8420981). Beta-alanine transport is inhibited by GABA (PubMed:8420981). Taurine transport is inhibited by GABA, beta-alanine, SNAP-5114, nigericin, nipecotic acid and ouabain (PubMed:22896705). {ECO:0000269|PubMed:22896705, ECO:0000269|PubMed:8420981}.
uniprot
proteins
amino_acid_sequence
MENRASGTTSNGETKPVCPAMEKVEEDGTLEREHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRRICPIFEGIGYASQMIVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKANDSMNVTSENATSPVIEFWERRVLKLSDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCILNSSTSFMAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREVLILIVSVISFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAGRFYDNIEDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMICIPAWSIYKLRTLKGPLRERLRQLVCPAEDLPQKNQPEPTAPATPMTSLLRLTELESNC
uniprot
proteins
function
FUNCTION: Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:22896705, PubMed:30270321, PubMed:8420981). Can also mediate transport of beta-alanine, taurine and hypotaurine and is the major taurine transporter in hepatocytes (PubMed:22896705, PubMed:30270321, PubMed:8420981). {ECO:0000269|PubMed:22896705, ECO:0000269|PubMed:30270321, ECO:0000269|PubMed:8420981}.
uniprot
proteins
mass_dalton
68285
uniprot
proteins
protein_family
SLC6A13 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22896705
uniprot
proteins
pubmed
30270321
uniprot
proteins
pubmed
8420981
uniprot
proteins
sequence_length
602
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22896705}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:22896705}; Multi-pass membrane protein {ECO:0000255}. Note=In the kidney, detected at the basolateral membranes of parts of proximal tubules.
uniprot
proteins
transmembrane_region
TRANSMEM 41..61; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 68..88; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 121..141; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 282..302; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 319..339; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 366..386; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 418..438; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 453..473; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 490..510; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 528..548; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins