Smarca2
entrez
67155
canonical
uniprot
Q6DIC0
canonical
ensembl
ENSMUSG00000024921
resolver
ensp
ENSMUSP00000025862
resolver
ensp
ENSMUSP00000108256
resolver
ensp
ENSMUSP00000134914
resolver
ensp
ENSMUSP00000134995
resolver
ensp
ENSMUSP00000135248
resolver
ensp
ENSMUSP00000135412
resolver
ensp
ENSMUSP00000135784
resolver
ensp
ENSMUSP00000146379
resolver
ensp
ENSMUSP00000146493
resolver
ensp
ENSMUSP00000146875
resolver
ensp
ENSMUSP00000146890
resolver
ensp
ENSMUSP00000146924
resolver
ensp
ENSMUSP00000146994
resolver
ensp
ENSMUSP00000270508
resolver
ensp
ENSMUSP00000270509
resolver
ensp
ENSMUSP00000270510
resolver
ensp
ENSMUSP00000270511
resolver
ensp
ENSMUSP00000270513
resolver
ensp
ENSMUSP00000270514
resolver
enst
ENSMUST00000025862
resolver
enst
ENSMUST00000112637
resolver
enst
ENSMUST00000176030
resolver
enst
ENSMUST00000176475
resolver
enst
ENSMUST00000207054
resolver
enst
ENSMUST00000208589
resolver
enst
ENSMUST00000208751
resolver
enst
ENSMUST00000209085
resolver
genesymbol
Smarca2
resolver
genesymbol_syn
Baf190b
resolver
genesymbol_syn
Brm
resolver
genesymbol_syn
Snf2a
resolver
genesymbol_syn
Snf2l2
resolver
uniprot
A0A140LHP6
resolver
uniprot
A0A140LIR3
resolver
uniprot
F2Z4A9
resolver
uniprot
H3BK47
resolver
uniprot
H3BLH0
resolver
uniprot
Q9D007
resolver
uniprot_entry
A0A140LHP6_MOUSE
resolver
uniprot_entry
A0A140LIR3_MOUSE
resolver
uniprot_entry
F2Z4A9_MOUSE
resolver
uniprot_entry
H3BK47_MOUSE
resolver
uniprot_entry
H3BLH0_MOUSE
resolver
uniprot_entry
Q9D007_MOUSE
resolver
uniprot_entry
SMCA2_MOUSE
resolver
amino_acid_sequence
MSTPTDPAAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPLSTMGSADFPQEGMHQLHKPMDGIHDKGIVEDVHCGSMKGTSMRPPHPGMGPPQSPMDQHSQGYMSPHPSPLGAPEHVSSPTPPQMPPSQPGALIPGDPQAMNQPNRGPSPFSPVQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGMQQQQQQQQQQQQQQQQQQQQQQQQQQPQQPQQQAQAQPQQQQQQQQQPALVSYNRPSGPGQELLLSGQSAPQKLSAPAPSGRPSPAPQAAVQPTATAVPGPSVQQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQELESLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGEPALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEESESDYEEEDEEEESSRQETEEKILLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDALTEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPVKEDVEKAKKRRGRPPAEKLSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKDLPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEESEEESNEEEEEDDEEESESEAKSVKVKIKLNKKEEKGRDTGKGKKRPNRGKAKPVVSDFDSDEEQEENEQSEASGTDNE
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. {ECO:0000250|UniProtKB:P51531, ECO:0000269|PubMed:17640523, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
uniprot
proteins
mass_dalton
180253
uniprot
proteins
post_translational_modification
PTM: During apoptosis, cleaved by cathepsin CTSG to produce a 160 kDa cleavage product which localizes to the cytosol. {ECO:0000250|UniProtKB:P51531}.; PTM: Ubiquitinated. {ECO:0000250|UniProtKB:P51531}.
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
15107404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17640523
uniprot
proteins
pubmed
19363039
uniprot
proteins
pubmed
20111005
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22366787
uniprot
proteins
pubmed
22952240
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
26601204
uniprot
proteins
sequence_length
1577
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00549}. Note=Localizes to sites of DNA damage. {ECO:0000250|UniProtKB:P51531}.
uniprot
proteins