Pus1
entrez
56361
canonical
uniprot
Q9WU56
canonical
ensembl
ENSMUSG00000029507
resolver
ensp
ENSMUSP00000031481
resolver
ensp
ENSMUSP00000031483
resolver
ensp
ENSMUSP00000083844
resolver
ensp
ENSMUSP00000130814
resolver
ensp
ENSMUSP00000289589
resolver
ensp
ENSMUSP00000289590
resolver
ensp
ENSMUSP00000289591
resolver
ensp
ENSMUSP00000289592
resolver
ensp
ENSMUSP00000289598
resolver
ensp
ENSMUSP00000345510
resolver
ensp
ENSMUSP00000361804
resolver
enst
ENSMUST00000086643
resolver
genesymbol
Pus1
resolver
uniprot
H7BX59
resolver
uniprot
Q3UUC6
resolver
uniprot
Q791J1
resolver
uniprot
Q8C250
resolver
uniprot
Q8VDQ3
resolver
uniprot
Q9EQD1
resolver
uniprot
Q9JJE5
resolver
uniprot_entry
H7BX59_MOUSE
resolver
uniprot_entry
PUS1_MOUSE
resolver
uniprot_sec
Q3UUC6
resolver
uniprot_sec
Q791J1
resolver
uniprot_sec
Q8C250
resolver
uniprot_sec
Q8VDQ3
resolver
uniprot_sec
Q9EQD1
resolver
uniprot_sec
Q9JJE5
resolver
amino_acid_sequence
MGFPRLWAALLRNWGRWTARPGPRVPGLPPMAGNKVPPALASHQPDRKGRGGWVWEETEHPAKRVKGGEDEEPPRKLPKRKIVLLMAYSGKGYHGMQRNLGSSQFRTIEDDLVSALVQAGCIPENHGTDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILDKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPTFAFAHKDRDVQDESYRLSAETLQQVNRLLACYKGTHNFHNFTSQKGPREPSARRYILEMYCEEPFVREGLEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGEEKVDVPKAPGLGLVLERVHFEKYNQRFGGDGLHEPLDWTQEEGKVTAFKEQYIYPTIVSTERDERSMAQWLNTLPIHNFSGTALGAADTGAKVPSSLEGSEGDGDTD
uniprot
proteins
ec_number
5.4.99.-
uniprot
proteins
ec_number
5.4.99.12
uniprot
proteins
function
FUNCTION: Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs (PubMed:10094309, PubMed:15327771, PubMed:27197761). Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA (PubMed:10094309). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (By similarity). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (By similarity). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (By similarity). Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA (PubMed:15327771). {ECO:0000250|UniProtKB:Q9Y606, ECO:0000269|PubMed:10094309, ECO:0000269|PubMed:15327771, ECO:0000269|PubMed:27197761}.; FUNCTION: [Isoform 3]: Does not form pseudouridine when expressed in vitro. {ECO:0000269|PubMed:11085940}.; FUNCTION: [Isoform 4]: Does not form pseudouridine when expressed in vitro. {ECO:0000269|PubMed:11085940}.
uniprot
proteins
mass_dalton
47502
uniprot
proteins
protein_family
TRNA pseudouridine synthase TruA family
uniprot
proteins
pubmed
10094309
uniprot
proteins
pubmed
11085940
uniprot
proteins
pubmed
15327771
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27197761
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y606}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y606}. Mitochondrion {ECO:0000250|UniProtKB:Q9Y606}.
uniprot
proteins