EIF2S3B
entrez
255308
canonical
uniprot
Q2VIR3
canonical
ensembl
ENSG00000180574
resolver
ensp
ENSP00000323063
resolver
ensp
ENSP00000445077
resolver
genesymbol
EIF2S3B
resolver
hgnc
HGNC:43863
resolver
uniprot
F8W810
resolver
uniprot
Q5I0X0
resolver
uniprot
Q6KF84
resolver
uniprot_entry
IF2GL_HUMAN
resolver
uniprot_sec
F8W810
resolver
uniprot_sec
Q5I0X0
resolver
uniprot_sec
Q6KF84
resolver
amino_acid_sequence
MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYQLDDPSCPRPECYRSCGSSMPDEFPTDIPGTKGNFRLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKERQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQETEVRPGIVSKDSEGKLMCKSIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQILGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD
uniprot
proteins
ec_number
3.6.5.3
uniprot
proteins
function
FUNCTION: Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198}.
uniprot
proteins
mass_dalton
51229
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
EIF2G subfamily
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16201836
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
9736774
uniprot
proteins
sequence_length
472
uniprot
proteins