Grin2b
entrez
14812
canonical
uniprot
Q01097
canonical
ensembl
ENSMUSG00000030209
resolver
ensp
ENSMUSP00000062284
resolver
ensp
ENSMUSP00000107536
resolver
ensp
ENSMUSP00000302918
resolver
ensp
ENSMUSP00000302919
resolver
enst
ENSMUST00000053880
resolver
enst
ENSMUST00000111905
resolver
genesymbol
Grin2b
resolver
uniprot
G3X9V4
resolver
uniprot
Q9DCB2
resolver
uniprot_entry
G3X9V4_MOUSE
resolver
uniprot_entry
NMDE2_MOUSE
resolver
uniprot_sec
Q9DCB2
resolver
amino_acid_sequence
MKPSAECCSPKFWLVLAVLAVSGSKARSQKSAPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVLADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFSDYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSTSSIDGLYDCDNPPFTTQPRSISKKPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKRRKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTKENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHLKHGTGDKHGVVGGVPAPWEKNLTNVDWEDRSGGNFCRSCPSKLHNYSSTVAGQNSGRQACIRCEACKKAGNLYDISEDNSLQELDQPAAPVAVSSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPRSVSLKDKGRFMDGSPYAHMFEMPAGESSFANKSSVTTAGHHHNNPGSGYMLSKSLYPDRVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKTRPDFRALVTNKPVVSALHGAVPGRFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV
uniprot
proteins
function
FUNCTION: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26912815). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents (PubMed:8789948). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (Probable) (PubMed:1377365, PubMed:20141836, PubMed:7790891). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (By similarity). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage (PubMed:20141836). Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (PubMed:20141836). {ECO:0000250|UniProtKB:P35438, ECO:0000250|UniProtKB:Q13224, ECO:0000269|PubMed:1377365, ECO:0000269|PubMed:20141836, ECO:0000269|PubMed:26912815, ECO:0000269|PubMed:7790891, ECO:0000269|PubMed:8789948, ECO:0000305|PubMed:26912815}.
uniprot
proteins
mass_dalton
165959
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues (PubMed:12451687). Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity (PubMed:20141836). {ECO:0000269|PubMed:12451687, ECO:0000269|PubMed:20141836}.
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
protein_family
NR2B/GRIN2B subfamily
uniprot
proteins
pubmed
10846156
uniprot
proteins
pubmed
12008020
uniprot
proteins
pubmed
12451687
uniprot
proteins
pubmed
1377365
uniprot
proteins
pubmed
14602821
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17329427
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19243221
uniprot
proteins
pubmed
20141836
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26912815
uniprot
proteins
pubmed
31196628
uniprot
proteins
pubmed
31424425
uniprot
proteins
pubmed
38452102
uniprot
proteins
pubmed
7790891
uniprot
proteins
pubmed
8789948
uniprot
proteins
sequence_length
1482
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1377365, ECO:0000269|PubMed:26912815}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q00960}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q00960}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q00960}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q13224}. Late endosome {ECO:0000269|PubMed:31424425}. Lysosome {ECO:0000269|PubMed:31424425}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10846156}. Note=Co-localizes with the motor protein KIF17 along microtubules. {ECO:0000269|PubMed:10846156}.
uniprot
proteins
transmembrane_region
TRANSMEM 558..576; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q00960"; TRANSMEM 631..646; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q00960"; TRANSMEM 818..837; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q00960
uniprot
proteins