FBLIM1
entrez
54751
canonical
uniprot
Q8WUP2
canonical
ensembl
ENSG00000162458
resolver
ensp
ENSP00000364921
resolver
ensp
ENSP00000364926
resolver
ensp
ENSP00000416387
resolver
ensp
ENSP00000578407
resolver
ensp
ENSP00000578409
resolver
ensp
ENSP00000578411
resolver
ensp
ENSP00000578414
resolver
ensp
ENSP00000578417
resolver
ensp
ENSP00000578418
resolver
ensp
ENSP00000578419
resolver
ensp
ENSP00000578421
resolver
ensp
ENSP00000585938
resolver
ensp
ENSP00000585939
resolver
ensp
ENSP00000614550
resolver
ensp
ENSP00000614553
resolver
ensp
ENSP00000788601
resolver
ensp
ENSP00000798998
resolver
genesymbol
FBLIM1
resolver
genesymbol_syn
FBLP1
resolver
hgnc
HGNC:24686
resolver
uniprot
B3KNY0
resolver
uniprot
Q5VVE0
resolver
uniprot
Q5VVE1
resolver
uniprot
Q8IX23
resolver
uniprot
Q96T00
resolver
uniprot
Q9UFD6
resolver
uniprot_entry
FBLI1_HUMAN
resolver
uniprot_sec
B3KNY0
resolver
uniprot_sec
Q5VVE0
resolver
uniprot_sec
Q5VVE1
resolver
uniprot_sec
Q8IX23
resolver
uniprot_sec
Q96T00
resolver
uniprot_sec
Q9UFD6
resolver
amino_acid_sequence
MASKPEKRVASSVFITLAPPRRDVAVAEEVRQAVCEARRGRPWEAPAPMKTPEAGLAGRPSPWTTPGRAAATVPAAPMQLFNGGCPPPPPVLDGEDVLPDLDLLPPPPPPPPVLLPSEEEAPAPMGASLIADLEQLHLSPPPPPPQAPAEGPSVQPGPLRPMEEELPPPPAEPVEKGASTDICAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCYQDTLERCGKCGEVVRDHIIRALGQAFHPSCFTCVTCARCIGDESFALGSQNEVYCLDDFYRKFAPVCSICENPIIPRDGKDAFKIECMGRNFHENCYRCEDCRILLSVEPTDQGCYPLNNHLFCKPCHVKRSAAGCC
uniprot
proteins
function
FUNCTION: Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455, ECO:0000269|PubMed:19074766}.
uniprot
proteins
mass_dalton
40670
uniprot
proteins
mutagenesis
MUTAGEN 7..8; /note="KR->TG: Localizes to cell-ECM adhesions; abolishes FLNA and FLNC interactions; failed to decorate actin filaments."; /evidence="ECO:0000269|PubMed:12679033
uniprot
proteins
pubmed
12496242
uniprot
proteins
pubmed
12679033
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18829455
uniprot
proteins
pubmed
19074766
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455}. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites (PubMed:12679033, PubMed:18829455). Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2 (PubMed:12679033). Isoform 2 is localized at actin stress fibers (PubMed:12496242). {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455}.
uniprot
proteins