PIWIL4
entrez
143689
canonical
uniprot
Q7Z3Z4
canonical
ensembl
ENSG00000134627
resolver
ensp
ENSP00000299001
resolver
genesymbol
PIWIL4
resolver
genesymbol_syn
HIWI2
resolver
genesymbol_syn
PIWI
resolver
hgnc
HGNC:18444
resolver
uniprot
A0A140VKG8
resolver
uniprot
B4DEG5
resolver
uniprot
Q68CZ4
resolver
uniprot
Q8N8G9
resolver
uniprot
Q8N9V8
resolver
uniprot
Q8NEH2
resolver
uniprot_entry
A0A140VKG8_HUMAN
resolver
uniprot_entry
PIWL4_HUMAN
resolver
uniprot_sec
B4DEG5
resolver
uniprot_sec
Q68CZ4
resolver
uniprot_sec
Q8N8G9
resolver
uniprot_sec
Q8N9V8
resolver
uniprot_sec
Q8NEH2
resolver
amino_acid_sequence
MSGRARVKARGIARSPSATEVGRIQASPLPRSVDLSNNEASSSNGFLGTSRISTNDKYGISSGDAGSTFMERGVKNKQDFMDLSICTREKLAHVRNCKTGSSGIPVKLVTNLFNLDFPQDWQLYQYHVTYIPDLASRRLRIALLYSHSELSNKAKAFDGAILFLSQKLEEKVTELSSETQRGETIKMTITLKRELPSSSPVCIQVFNIIFRKILKKLSMYQIGRNFYNPSEPMEIPQHKLSLWPGFAISVSYFERKLLFSADVSYKVLRNETVLEFMTALCQRTGLSCFTQTCEKQLIGLIVLTRYNNRTYSIDDIDWSVKPTHTFQKRDGTEITYVDYYKQQYDITVSDLNQPMLVSLLKKKRNDNSEAQLAHLIPELCFLTGLTDQATSDFQLMKAVAEKTRLSPSGRQQRLARLVDNIQRNTNARFELETWGLHFGSQISLTGRIVPSEKILMQDHICQPVSAADWSKDIRTCKILNAQSLNTWLILCSDRTEYVAESFLNCLRRVAGSMGFNVDYPKIIKVQENPAAFVRAIQQYVDPDVQLVMCILPSNQKTYYDSIKKYLSSDCPVPSQCVLARTLNKQGMMMSIATKIAMQMTCKLGGELWAVEIPLKSLMVVGIDVCKDALSKDVMVVGCVASVNPRITRWFSRCILQRTMTDVADCLKVFMTGALNKWYKYNHDLPARIIVYRAGVGDGQLKTLIEYEVPQLLSSVAESSSNTSSRLSVIVVRKKCMPRFFTEMNRTVQNPPLGTVVDSEATRNEWYDFYLISQVACRGTVSPTYYNVIYDDNGLKPDHMQRLTFKLCHLYYNWPGIVSVPAPCQYAHKLTFLVAQSIHKEPSLELANHLFYL
uniprot
proteins
function
FUNCTION: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins (By similarity). The PIWIL4-piRNA pathway acts in the nucleus and mediates silencing of active transposons: engages with nascent transposable element transcripts and governs the piRNA-directed DNA methylation and subsequent repression of transposons (By similarity). In contrast to PIWIL1 and PIWIL2, does not show endonuclease activity (By similarity). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (By similarity). Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association (By similarity). The piRNA process acts upstream of known mediators of DNA methylation (By similarity). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-incompetent' component that loads cleaved piRNAs from the 'slicer-competent' component PIWIL2 and target them on genomic transposon loci in the nucleus (By similarity). May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci (PubMed:17544373). In addition to its role in germline, PIWIL4 also plays a role in the regulation of somatic cells activities (By similarity). Plays a role in pancreatic beta cell function and insulin secretion (By similarity). Involved in maintaining cell morphology and functional integrity of retinal epithelial through Akt/GSK3alpha/beta signaling pathway (PubMed:28025795). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of cells proliferation in tumors (PubMed:22483988). {ECO:0000250|UniProtKB:Q4G033, ECO:0000250|UniProtKB:Q8CGT6, ECO:0000269|PubMed:17544373, ECO:0000269|PubMed:22483988, ECO:0000269|PubMed:28025795}.
uniprot
proteins
mass_dalton
96589
uniprot
proteins
post_translational_modification
PTM: Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein (TDRD1, TDRKH/TDRD2 and TDRD9) and subsequent localization to the meiotic nuage, also named P granule. {ECO:0000250|UniProtKB:Q8CGT6}.
uniprot
proteins
protein_family
Argonaute family
uniprot
proteins
protein_family
Piwi subfamily
uniprot
proteins
pubmed
12906857
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17544373
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
22483988
uniprot
proteins
pubmed
24969058
uniprot
proteins
pubmed
25038252
uniprot
proteins
pubmed
28025795
uniprot
proteins
pubmed
28711973
uniprot
proteins
pubmed
30145353
uniprot
proteins
sequence_length
852
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25038252, ECO:0000269|PubMed:28025795}. Cytoplasm {ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:25038252, ECO:0000269|PubMed:28025795}. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. PIWIL2/MILI is required for nuclear localization (By similarity). {ECO:0000250|UniProtKB:Q8CGT6}.
uniprot
proteins