METTL15
entrez
196074
canonical
uniprot
A6NJ78
canonical
ensembl
ENSG00000169519
resolver
ensp
ENSP00000307251
resolver
ensp
ENSP00000384369
resolver
ensp
ENSP00000385507
resolver
ensp
ENSP00000689748
resolver
ensp
ENSP00000773953
resolver
genesymbol
METTL15
resolver
genesymbol_syn
METT5D1
resolver
hgnc
HGNC:26606
resolver
uniprot
A8MRS5
resolver
uniprot
B7WNU2
resolver
uniprot
Q3MHD3
resolver
uniprot
Q8N601
resolver
uniprot
Q8NBA7
resolver
uniprot_entry
MET15_HUMAN
resolver
uniprot_sec
A8MRS5
resolver
uniprot_sec
B7WNU2
resolver
uniprot_sec
Q3MHD3
resolver
uniprot_sec
Q8N601
resolver
uniprot_sec
Q8NBA7
resolver
amino_acid_sequence
MLRYPYFCRMYKECLSCWLESGIPNLGVWPNRIHTTAEKYREYEAREQTDQTQAQELHRSQDRDFETMAKLHIPVMVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAYALAEHLSELYPKQIRAMLGQFSQAEALLMKAGVQPGTFDGVLMDLGCSSMQLDTPERGFSLRKDGPLDMRMDGGRYPDMPTAADVVNALDQQALASILRTYGEEKHAKKIASAIVQARSIYPITRTQQLASIVAGAFPPSAIYTRKDLLQRSTHIATKTFQALRIFVNNELNELYTGLKTAQKFLRPGGRLVALSFHSLEDRIVKRFLLGISMTERFNLSVRQQVMKTSQLGSDHENTEEVSMRRAPLMWELIHKKVLSPQDQDVQDNPRGRSAKLRAAIKL
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA (PubMed:31665743, PubMed:32371392). Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits (PubMed:31665743, PubMed:32371392). {ECO:0000269|PubMed:31665743, ECO:0000269|PubMed:32371392}.
uniprot
proteins
mass_dalton
46121
uniprot
proteins
mutagenesis
MUTAGEN 98..101; /note="GSGG->ASAA: Abolished methylation of 12S rRNA position C839."; /evidence="ECO:0000269|PubMed:32371392"; MUTAGEN 119..120; /note="DR->AA: Absence of methylation of 12S rRNA position C839 and decreased methylation at position C841."; /evidence="ECO:0000269|PubMed:31665743"; MUTAGEN 298; /note="E->A: Decreased methylation of 12S rRNA positions C839 and C841."; /evidence="ECO:0000269|PubMed:31665743
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
protein_family
RsmH family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
31665743
uniprot
proteins
pubmed
32371392
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:31665743, ECO:0000269|PubMed:32371392}.
uniprot
proteins