GRIK5
entrez
2901
canonical
uniprot
Q16478
canonical
ensembl
ENSG00000105737
resolver
ensp
ENSP00000301218
resolver
ensp
ENSP00000470251
resolver
ensp
ENSP00000786120
resolver
ensp
ENSP00000786121
resolver
genesymbol
GRIK5
resolver
genesymbol_syn
GRIK2
resolver
hgnc
HGNC:4583
resolver
uniprot
Q8WWG8
resolver
uniprot_entry
GRIK5_HUMAN
resolver
uniprot_sec
Q8WWG8
resolver
amino_acid_sequence
MPAELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGSAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGVPAEATSPPRPRPGPAGPRELAEHE
uniprot
proteins
function
FUNCTION: Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Cannot form functional channels on its own and produces channel activity only in heteromeric assembly with GRIK1 and GRIK2 subunits (PubMed:1321949, PubMed:14511640, PubMed:8730589). Can form functional heteromeric receptors with GRIK3 (By similarity). {ECO:0000250|UniProtKB:Q63273, ECO:0000269|PubMed:1321949, ECO:0000269|PubMed:14511640, ECO:0000269|PubMed:8730589}.
uniprot
proteins
mass_dalton
109265
uniprot
proteins
mutagenesis
MUTAGEN 863; /note="R->E: Retained in the endoplasmic reticulum; when associated with E-865."; /evidence="ECO:0000269|PubMed:14511640"; MUTAGEN 865; /note="R->E: Retained in the endoplasmic reticulum; when associated with E-863."; /evidence="ECO:0000269|PubMed:14511640
uniprot
proteins
protein_family
GRIK5 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
1321949
uniprot
proteins
pubmed
14511640
uniprot
proteins
pubmed
8730589
uniprot
proteins
sequence_length
980
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14511640}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q61626}; Multi-pass membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q61626}; Multi-pass membrane protein {ECO:0000255}. Note=Association with GRIK2 is required for its cell membrane localization and channel activity. {ECO:0000269|PubMed:14511640}.
uniprot
proteins
transmembrane_region
TRANSMEM 545..565; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 623..643; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 804..824; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins