Msh3
entrez
17686
canonical
uniprot
P13705
canonical
ensembl
ENSMUSG00000014850
resolver
ensp
ENSMUSP00000022220
resolver
ensp
ENSMUSP00000140002
resolver
ensp
ENSMUSP00000288733
resolver
enst
ENSMUST00000022220
resolver
enst
ENSMUST00000185852
resolver
genesymbol
Msh3
resolver
genesymbol_syn
Rep-3
resolver
uniprot
A0A087WQ16
resolver
uniprot
E9QPY6
resolver
uniprot_entry
A0A087WQ16_MOUSE
resolver
uniprot_entry
E9QPY6_MOUSE
resolver
uniprot_entry
MSH3_MOUSE
resolver
amino_acid_sequence
MPRGKSASGGSTAAGPGPGRQTVLSRFFRSAGSLRSSASSTEPAEKVTEGDSRKRSLGNGGPTKKKARKVPEKEEENISVASHHPEAKKCLRPRIVLKSLEKLKEFCCDSALPQNRVQTEALRERLEVLPRCTDFEDITLQRAKNAVLSEDSKSQANQKDSQFGPCPEVFQKTSDCKPFNKRSKSVYTPLELQYLDMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYCHLDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAIGDNKSSVFSRKLTALYTKSTLIGEDVNPLIRLDDSVNIDEVMTDTSTNYLLCIYEEKENIKDKKKGNLSVGVVGVQPATGEVVFDCFQDSASRLELETRISSLQPVELLLPSDLSEPTEMLIQRATNVSVRDDRIRVERMNNTYFEYSHAFQTVTEFYAREIVDSQGSQSLSGVINLEKPVICALAAVIRYLKEFNLEKMLSKPESFKQLSSGMEFMRINGTTLRNLEMVQNQTDMKTKGSLLWVLDHTKTSFGRRKLKNWVTQPLLKLREINARLDAVSDVLHSESSVFEQIENLLRKLPDVERGLCSIYHKKCSTQEFFLIVKSLCQLKSELQALMPAVNSHVQSDLLRALIVELLSPVEHYLKVLNGPAAKVGDKTELFKDLSDFPLIKKRKNEIQEVIHSIQMRLQEFRKILKLPSLQYVTVSGQEFMIEIKNSAVSCIPADWVKVGSTKAVSRFHPPFIVESYRRLNQLREQLVLDCNAEWLGFLENFGEHYHTLCKAVDHLATVDCIFSLAKVAKQGNYCRPTLQEEKKIIIKNGRHPMIDVLLGEQDQFVPNSTSLSDSERVMIITGPNMGGKSSYIKQVTLVTIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGRSTFMEQLTDTAEIIRRASPQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKCYPEQVGNYHMGFLVNEDESKQDSGDMEQMPDSVTFLYQITRGIAARSYGLNVAKLADVPREVLQKAAHKSKELEGLVSLRRKRLECFTDLWMTHSVKDLHTWADKLEMEEIQTSLPH
uniprot
proteins
function
FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
123074
uniprot
proteins
protein_family
DNA mismatch repair MutS family
uniprot
proteins
protein_family
MSH3 subfamily
uniprot
proteins
pubmed
2674679
uniprot
proteins
pubmed
7926796
uniprot
proteins
sequence_length
1091
uniprot
proteins