Ccna2
entrez
12428
canonical
uniprot
P51943
canonical
ensembl
ENSMUSG00000027715
resolver
ensp
ENSMUSP00000029270
resolver
enst
ENSMUST00000029270
resolver
genesymbol
Ccna2
resolver
genesymbol_syn
Ccna
resolver
genesymbol_syn
Cyca
resolver
genesymbol_syn
Cyca2
resolver
uniprot
Q61459
resolver
uniprot
Q8BRG1
resolver
uniprot_entry
CCNA2_MOUSE
resolver
uniprot_sec
Q61459
resolver
uniprot_sec
Q8BRG1
resolver
amino_acid_sequence
MPGTSRHSGRDAGSALLSLHQEDQENVNPEKLAPAQQPRAQAVLKAGNVRGPAPQQKLKTRRVAPLKDLPINDEHVTAGPSWKAVSKQPAFTIHVDEAEETQKRPAELKETECEDALAFNAAVSLPGARKPLTPLDYPMDGSFESPHAMDMSIVLEDKPVNVNEVPDYQEDIHTYLREMEVKCKPKVGYMKRQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYSKKQVLRMEHLVLKVLAFDLAAPTVNQFLTQYFLHLQPANCKVESLAMFLGELSLIDADPYLKYLPSLIAGAAFHLALYTVTGQSWPESLAQQTGYTLESLKPCLVDLHQTYLKAPQHAQQSIREKYKHSKYHSVSLLNPPETLSV
uniprot
proteins
function
FUNCTION: Essential for the control of the cell cycle at G1/S and G2/M transition (By similarity). Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle (By similarity). {ECO:0000250|UniProtKB:P20248}.
uniprot
proteins
mass_dalton
47269
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase. Ubiquitinated during the G1 phase by the SCF(FBXO31) complex, leading to its proteasomal degradation. {ECO:0000250|UniProtKB:P20248}.
uniprot
proteins
protein_family
Cyclin AB subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
10068472
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32973148
uniprot
proteins
pubmed
8565853
uniprot
proteins
pubmed
8575639
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32973148}. Cytoplasm {ECO:0000269|PubMed:32973148}. Note=Exclusively nuclear during interphase. Detected in the nucleus and the cytoplasm at prophase. Cytoplasmic when associated with SCAPER. {ECO:0000250|UniProtKB:P20248}.
uniprot
proteins