DTX1
entrez
1840
canonical
uniprot
Q86Y01
canonical
ensembl
ENSG00000135144
resolver
ensp
ENSP00000257600
resolver
ensp
ENSP00000510707
resolver
enst
ENST00000257600
resolver
enst
ENST00000548759
resolver
genesymbol
DTX1
resolver
hgnc
HGNC:3060
resolver
uniprot
O60630
resolver
uniprot
Q9BS04
resolver
uniprot_entry
DTX1_HUMAN
resolver
uniprot_sec
O60630
resolver
uniprot_sec
Q9BS04
resolver
amino_acid_sequence
MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDARGSVVLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLTVGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPPLPPPPPPGGPPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGARTPGQNNLNRPGPQRTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAAAKA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and proteasomal degradation of MEKK1, thereby modulating signaling pathways involved in cell fate determination (By similarity). Regulates the Notch signaling pathway, acting predominantly as a positive regulator but functioning as a context-dependent negative regulator in specific developmental or cellular settings. Mediates the antineural activity of Notch signaling, likely by inhibiting transcriptional activation mediated by MATCH1. Negatively regulates Notch signaling by controlling the activity of PIP4K2C, a lipid kinase that promotes recycling of Notch receptors from RAB4A-positive endosomes to the cell surface (PubMed:29440432). Participates in several developmental and immune processes, including neurogenesis, lymphogenesis, and myogenesis. Influences lymphocyte differentiation by promoting B-cell development at the expense of T-cell development, suggesting functional antagonism of NOTCH1 in this context. Also promotes degradation of PRKCQ via the endosome-lysosome pathway, contributing to PKCtheta down-regulation during T-cell anergy (PubMed:25000980). In addition, facilitates differentiation of Th17 cells by inducing expression and DNA-binding activity of RORgT (PubMed:32736174). {ECO:0000250|UniProtKB:Q61010, ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:11869684, ECO:0000269|PubMed:25000980, ECO:0000269|PubMed:29440432, ECO:0000269|PubMed:32736174, ECO:0000269|PubMed:9590294}.
uniprot
proteins
mass_dalton
67368
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH. {ECO:0000269|PubMed:17028573}.
uniprot
proteins
protein_family
Deltex family
uniprot
proteins
pubmed
11564735
uniprot
proteins
pubmed
11869684
uniprot
proteins
pubmed
12670957
uniprot
proteins
pubmed
12753744
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17028573
uniprot
proteins
pubmed
21124883
uniprot
proteins
pubmed
25000980
uniprot
proteins
pubmed
29440432
uniprot
proteins
pubmed
32736174
uniprot
proteins
pubmed
9590294
uniprot
proteins
sequence_length
620
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:25000980}. Nucleus. Endosome {ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:29440432}. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear. {ECO:0000269|PubMed:11564735}.
uniprot
proteins