Plcd1
entrez
24655
canonical
uniprot
P10688
canonical
ensembl
ENSRNOG00000032238
resolver
ensp
ENSRNOP00000076591
resolver
ensp
ENSRNOP00000090035
resolver
enst
ENSRNOT00000110954
resolver
enst
ENSRNOT00000113471
resolver
genesymbol
Plcd1
resolver
uniprot
A0A8I5Y0I7
resolver
uniprot
A0A8I6GIK0
resolver
uniprot
Q80WI4
resolver
uniprot
Q9QVD3
resolver
uniprot
Q9QVD4
resolver
uniprot
Q9QVD5
resolver
uniprot_entry
A0A8I5Y0I7_RAT
resolver
uniprot_entry
A0A8I6GIK0_RAT
resolver
uniprot_entry
PLCD1_RAT
resolver
uniprot_sec
Q80WI4
resolver
uniprot_sec
Q9QVD3
resolver
uniprot_sec
Q9QVD4
resolver
uniprot_sec
Q9QVD5
resolver
amino_acid_sequence
MDSGRDFLTLHGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVQGLRKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDGYARKIFRECDHSQTDSLEDEEIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPILLDQPLDGVTTSLPSPEQLKGKILLKGKKLGGLLPAGGENGSEATDVSDEVEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRHNVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQQLPKVNKNKNSIVDPKVIVEIHGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISIQD
uniprot
proteins
ec_number
3.1.4.11
uniprot
proteins
function
FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:16000311). Essential for trophoblast and placental development (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (By similarity). {ECO:0000250|UniProtKB:P51178, ECO:0000250|UniProtKB:Q8R3B1, ECO:0000269|PubMed:16000311}.
uniprot
proteins
mass_dalton
85962
uniprot
proteins
mutagenesis
MUTAGEN 311; /note="H->A: Lowers activity 10000-fold."; /evidence="ECO:0000269|PubMed:9565585"; MUTAGEN 312; /note="N->A: Lowers activity 10000-fold."; /evidence="ECO:0000269|PubMed:9565585"; MUTAGEN 320; /note="L->A: Lowers activity 3-fold."; /evidence="ECO:0000269|PubMed:9565585"; MUTAGEN 341; /note="E->A,H,Q: Lowers activity 200000-fold."; /evidence="ECO:0000269|PubMed:9565585"; MUTAGEN 343; /note="D->A: Lowers activity 1000-fold."; /evidence="ECO:0000269|PubMed:9565585"; MUTAGEN 343; /note="D->R: Lowers activity 100000-fold."; /evidence="ECO:0000269|PubMed:9565585"; MUTAGEN 356; /note="H->A: Lowers activity 1000-fold."; /evidence="ECO:0000269|PubMed:9565585"; MUTAGEN 360; /note="F->A: Lowers activity 4-fold."; /evidence="ECO:0000269|PubMed:9565585"; MUTAGEN 390; /note="E->A,H,K: Lowers activity 1000-fold."; /evidence="ECO:0000269|PubMed:9565585"; MUTAGEN 390; /note="E->Q: Lowers activity 200-fold."; /evidence="ECO:0000269|PubMed:9565585"; MUTAGEN 438; /note="K->A: Lowers activity very slightly."; /evidence="ECO:0000269|PubMed:9565585"; MUTAGEN 440; /note="K->A: No effect on activity towards phosphatidylinositol 4-monophosphate. Lowers activity 5-fold towards phosphatidylinositol 4,5-bisphosphate."; /evidence="ECO:0000269|PubMed:9565585"; MUTAGEN 522; /note="S->A: Lowers activity 10000-fold."; /evidence="ECO:0000269|PubMed:9565585"; MUTAGEN 549; /note="R->A: Lowers activity 600-fold."; /evidence="ECO:0000269|PubMed:9565585"; MUTAGEN 551; /note="Y->A: Lowers activity 600-fold."; /evidence="ECO:0000269|PubMed:9565585"; MUTAGEN 555; /note="W->A: Lowers activity very slightly."; /evidence="ECO:0000269|PubMed:9565585
uniprot
proteins
pubmed
11706040
uniprot
proteins
pubmed
12054611
uniprot
proteins
pubmed
1313009
uniprot
proteins
pubmed
16000311
uniprot
proteins
pubmed
1684614
uniprot
proteins
pubmed
24098488
uniprot
proteins
pubmed
3390863
uniprot
proteins
pubmed
8521504
uniprot
proteins
pubmed
8602259
uniprot
proteins
pubmed
8784353
uniprot
proteins
pubmed
9062102
uniprot
proteins
pubmed
9565585
uniprot
proteins
sequence_length
756
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11706040}; Peripheral membrane protein {ECO:0000269|PubMed:11706040}; Cytoplasmic side {ECO:0000305|PubMed:11706040}. Cytoplasm {ECO:0000269|PubMed:11706040}. Note=The membrane binding is driven by the C2 domain (PubMed:11706040). Localized predominantly to the plasma membrane because of the high affinity of the PH domain for PtdIns(4,5)P2 (By similarity). Translocation to the cytosol is a consequence of the higher affinity for Ins(1,4,5)P3 than PtdIns(4,5)P2 and therefore reflects cellular levels of Ins(1,4,5)P3 (By similarity). {ECO:0000250|UniProtKB:P51178, ECO:0000269|PubMed:11706040}.
uniprot
proteins