Mcf2l
entrez
117020
canonical
uniprot
Q63406
canonical
ensembl
ENSRNOG00000028426
resolver
ensembl
ENSRNOG00055015089
resolver
ensembl
ENSRNOG00060020542
resolver
ensembl
ENSRNOG00065009338
resolver
ensp
ENSRNOP00000068993
resolver
ensp
ENSRNOP00000075224
resolver
ensp
ENSRNOP00000077897
resolver
ensp
ENSRNOP00000083374
resolver
ensp
ENSRNOP00000085354
resolver
ensp
ENSRNOP00055021158
resolver
ensp
ENSRNOP00060029819
resolver
ensp
ENSRNOP00065011193
resolver
enst
ENSRNOT00000079096
resolver
enst
ENSRNOT00000111168
resolver
enst
ENSRNOT00055025955
resolver
enst
ENSRNOT00060036252
resolver
enst
ENSRNOT00065014967
resolver
genesymbol
Mcf2l
resolver
genesymbol_syn
Ost
resolver
uniprot
A0A8I5ZZZ7
resolver
uniprot_entry
A0A8I5ZZZ7_RAT
resolver
uniprot_entry
MCF2L_RAT
resolver
amino_acid_sequence
MSNCWCFIFCKERVRSNSSSPQHDGTSREEADHQVDVSDGIRLVPDKAEATMATASDEIMHQDIVPLCAADIQEQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRQDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDEFKMKVPVMMLSSVPELHGYIDKSQLTEDLGGTLDYCHSRWLCHRTAIESFALMVKQTAQMLQAFGTELAETELPNDVQSTSLVLSAHTEKKAKVKEDLQLALTEGNSILESLREPLAESIVHSVNQDQLDNQATVKRLLTQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKTALDSMSQKIAAFTDVGNSLAHVQHLLKDLTTFEEKSSVAVDKARALSLEGQQLIENRHYAVDSIHPKCEELQHLCDHFASEVTRRRDLLSKSLELHSLLETSMKWSDEGIFLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNKIYKEYECILNQDLLEHVQKVFQKQESTEEMFHRRQASLKKLAAKQTRPVQPVAPRPEALTKSPSPSPGSWRSSENSSSEGNALRRGPYRRAKSEMSEPRQGRTSSTGEEEESLAILRRHVMNELLDTERAYVEELLCVLEGYAAEMDNPLMAHLISTGLQNKKNILFGNMEEIYHFHNRIFLRELESCIDCPELVGRCFLERMEEFQIYEKYCQNKPRSESLWRQCSDCPFFQECQKKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSKHCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKKGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMTAVGITENVKGDTKKFEIWYNAREEVYIIQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSHSLPLPTPASTSPTKGSTRNVKKLEDRKTDPLCLEGCVSSSLPKPPEKGKGWSKTSHSLEAPEEDGGWSSAEELINSSDAEEDGGVGPRKLVPGKYTVLMDGEKGGSDTLAMRSGDMVEVVEEGTEGLWYVRDLTSSKEGWVPASSLATLLGKSSSAQCLSSSGKTHCARQLCPEPAKILSPEPV
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways. Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus. {ECO:0000269|PubMed:7957046}.
uniprot
proteins
mass_dalton
129410
uniprot
proteins
post_translational_modification
PTM: Mainly phosphorylated on serine. {ECO:0000269|PubMed:7957046}.
uniprot
proteins
protein_family
MCF2 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7957046
uniprot
proteins
sequence_length
1149
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7957046}. Cell membrane {ECO:0000250|UniProtKB:Q64096}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64096}; Cytoplasmic side {ECO:0000250|UniProtKB:Q64096}.
uniprot
proteins