Rnf34
entrez
282845
canonical
uniprot
Q6AYH3
canonical
ensembl
ENSRNOG00000001331
resolver
ensp
ENSRNOP00000001799
resolver
ensp
ENSRNOP00000080689
resolver
enst
ENSRNOT00000001799
resolver
enst
ENSRNOT00000103449
resolver
genesymbol
Rnf34
resolver
uniprot
A0A8I6G4W4
resolver
uniprot
Q8CIP0
resolver
uniprot_entry
A0A8I6G4W4_RAT
resolver
uniprot_entry
RNF34_RAT
resolver
uniprot_sec
Q8CIP0
resolver
amino_acid_sequence
MKAGATSMWASCCGLLNEVMGTGAVRGQQAGFPGSTGPFRFTPSSDFPTYPPAATEGPNIVCKACGLSFSVFRKKHVCCDCKKDFCSLCSVSQENLRRCSTCHLLQETAFQRPQLMRLKVKDLRQYLLLRNVPTDTCREKEDLVDLVLCHRGLGSGDGLDSRSLSSSRSQTSSFFTQSYFSNYTPPSATVSSFQGELMDREGTFRSEVLTQVQSELASANTDDEDGEEDDDDDDDDDDEDDDEQEENLEEQNPGLSKKKARASLSDLSSLEEVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRLYKENEENQKSYGERMQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells. Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation. {ECO:0000250|UniProtKB:Q969K3, ECO:0000269|PubMed:12859687}.
uniprot
proteins
mass_dalton
42681
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q969K3}.
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by caspases upon induction of apoptosis by TNF. {ECO:0000250|UniProtKB:Q969K3}.; PTM: Autoubiquitinated (in vitro). {ECO:0000269|PubMed:12859687}.
uniprot
proteins
pubmed
12859687
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q969K3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q969K3}. Endomembrane system {ECO:0000269|PubMed:12859687}; Peripheral membrane protein {ECO:0000305}. Nucleus {ECO:0000250|UniProtKB:Q969K3}. Nucleus speckle {ECO:0000250|UniProtKB:Q969K3}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q969K3}.
uniprot
proteins