Slc19a1
entrez
29723
canonical
uniprot
Q62866
canonical
ensembl
ENSRNOG00000001232
resolver
ensembl
ENSRNOG00055022821
resolver
ensembl
ENSRNOG00060019888
resolver
ensembl
ENSRNOG00065028743
resolver
ensp
ENSRNOP00000060579
resolver
ensp
ENSRNOP00055031805
resolver
ensp
ENSRNOP00060028301
resolver
ensp
ENSRNOP00065040759
resolver
enst
ENSRNOT00000065236
resolver
enst
ENSRNOT00055039197
resolver
enst
ENSRNOT00060034474
resolver
enst
ENSRNOT00065049647
resolver
genesymbol
Slc19a1
resolver
uniprot
D3ZQS7
resolver
uniprot
Q9QUM8
resolver
uniprot_entry
S19A1_RAT
resolver
uniprot_sec
D3ZQS7
resolver
uniprot_sec
Q9QUM8
resolver
amino_acid_sequence
MVPTGQVAEKQACEEPRQDRELKSWRWLVFYLCFFGFMAQLRPGESFITPYLLERNFTKEQVTNEIIPMLPYSHLAVLVPIFLLTDYLRYKPVLVLQCLSFVCVWLLLLLGTSVVHMQLMEVFYSITMAARIAYSSYIFSLVQPSRYQRMASYSRAAVLLGVFISSVLGQVLVTLGGISTYMLNCISLGFILFSLSLSLFLKRPKRSLFFNRSALVQGALPCELDQMHPGPGRPEPRKLERMLGTCRDSFLVRMLSELVKNVRQPQLRLWCLWWVFNSAGYYLITYYVHVLWKITDSRLNYNGAVDAASTLLSAITAFTAGFVNIRWALWSKLVIASVIAIQAGLVFCMFQIPDIWVCYVTFVLFRGAYQFLVPIATFQIASSLSKELCALVFGINTFLATALKTSITLVVSDKRGLGLQVHQQFRIYFMYFLTLSIICLAWAGLDGLRYYRRGRHQPLAQAQALSPLEDSVQAISLQDGDLRRPQPSAPQLLPEDGSVEDGRADLRVEAKA
uniprot
proteins
function
FUNCTION: Antiporter that mediates the import of reduced folates, driven by the export of organic anions (PubMed:11600421, PubMed:19243012). Also acts as an importer of immunoreactive cyclic dinucleotides, but with a lower transporter activity (By similarity). Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (By similarity). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (By similarity). Also mediates the import of antifolate drug methotrexate (PubMed:10827155, PubMed:11600421). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (By similarity). {ECO:0000250|UniProtKB:P41438, ECO:0000250|UniProtKB:P41440, ECO:0000269|PubMed:10827155, ECO:0000269|PubMed:11600421, ECO:0000269|PubMed:19243012}.
uniprot
proteins
mass_dalton
58108
uniprot
proteins
protein_family
Reduced folate carrier (RFC) transporter (TC 2.A.48) family
uniprot
proteins
pubmed
10827155
uniprot
proteins
pubmed
11600421
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19243012
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19243012}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41440}. Apical cell membrane {ECO:0000250|UniProtKB:P41440}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41440}. Basolateral cell membrane {ECO:0000269|PubMed:19243012}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41440}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 63..85; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 90..110; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 115..137; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 152..176; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 182..200; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 267..292; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 301..323; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 330..350; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 354..377; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 392..415; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 424..448; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P41440
uniprot
proteins