TOMM6
entrez
100188893
canonical
uniprot
Q96B49
canonical
ensembl
ENSG00000214736
resolver
ensp
ENSP00000381856
resolver
ensp
ENSP00000381859
resolver
ensp
ENSP00000601310
resolver
ensp
ENSP00000601311
resolver
ensp
ENSP00000601314
resolver
enst
ENST00000398881
resolver
enst
ENST00000398884
resolver
enst
ENST00000931251
resolver
enst
ENST00000931252
resolver
enst
ENST00000931255
resolver
genesymbol
TOMM6
resolver
genesymbol_syn
OBTP
resolver
genesymbol_syn
TOM6
resolver
hgnc
HGNC:34528
resolver
uniprot
B2DG15
resolver
uniprot
Q9UH52
resolver
uniprot_entry
TOM6_HUMAN
resolver
uniprot_sec
B2DG15
resolver
uniprot_sec
Q9UH52
resolver
amino_acid_sequence
MASSTVPVSAAGSANETPEIPDNVGDWLRGVYRFATDRNDFRRNLILNLGLFAAGVWLARNLSDIDLMAPQPGV
uniprot
proteins
function
FUNCTION: Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (PubMed:40080546). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (PubMed:40080546). {ECO:0000269|PubMed:40080546}.
uniprot
proteins
mass_dalton
8002
uniprot
proteins
protein_family
Tom6 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18331822
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
40080546
uniprot
proteins
sequence_length
74
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18331822}; Single-pass membrane protein {ECO:0000269|PubMed:40080546}.
uniprot
proteins
transmembrane_region
TRANSMEM 41..64; /note="Helical"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ
uniprot
proteins