Dusp2
entrez
13537
canonical
uniprot
Q05922
canonical
ensembl
ENSMUSG00000027368
resolver
ensp
ENSMUSP00000028846
resolver
genesymbol
Dusp2
resolver
genesymbol_syn
Pac-1
resolver
genesymbol_syn
Pac1
resolver
uniprot
Q60640
resolver
uniprot
Q80ZN1
resolver
uniprot_entry
DUSP2_MOUSE
resolver
uniprot_sec
Q60640
resolver
uniprot_sec
Q80ZN1
resolver
amino_acid_sequence
MPIAMGLETACELECAALGALLREPREAERTLLLDCRPFLAFCRSHVRAARPVPWNALLRRRARGTPAAALACLLPDRALRARLGRGELARAVVLDESSASVAELPPDGPAHLLLAALQHEMRGGPTTVCFLRGGFKSFQTYCPDLCSEAPAQALPPAGAENSNSDPRVPIYDQGGPVEILPYLYLGSCNHSSDLQGLQACGITAVLNVSASCPNHFEGLFHYKSIPVEDNQMVEISAWFQEAISFIDSVKNSGGRVLVHCQAGISRSATICLAYLIQSHRVRLDEAFDFVKQRRGVISPNFSFMGQLLQLETQVLCH
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine (PubMed:16288922). Can dephosphorylate MAPK1 (PubMed:16288922). {ECO:0000269|PubMed:16288922}.
uniprot
proteins
mass_dalton
34576
uniprot
proteins
mutagenesis
MUTAGEN 60; /note="R->A: Does not affect interaction with MAPK1."; /evidence="ECO:0000269|PubMed:7681221"; MUTAGEN 61; /note="R->A: Does not affect interaction with MAPK1. Loss of interaction with MAPK1; when associated with A-62."; /evidence="ECO:0000269|PubMed:7681221"; MUTAGEN 62; /note="R->A: Loss of interaction with MAPK1. Loss of interaction with MAPK1; when associated with A-61."; /evidence="ECO:0000269|PubMed:7681221"; MUTAGEN 230; /note="D->A: Loss of phosphatase activity."; /evidence="ECO:0000269|PubMed:7681221"; MUTAGEN 261; /note="C->S: Loss of phosphatase activity. Does not affect interaction with MAPK1."; /evidence="ECO:0000269|PubMed:7681221"; MUTAGEN 292; /note="K->A: Does not affect phosphatase activity. Loss of phosphatase activity; when associated with A-294 and A-295. Does not affect interaction with MAPK1."; /evidence="ECO:0000269|PubMed:7681221"; MUTAGEN 294; /note="R->A: Loss of phosphatase activity. Loss of phosphatase activity; when associated with A-292 and A-295. Does not affect interaction with MAPK1."; /evidence="ECO:0000269|PubMed:7681221"; MUTAGEN 294; /note="R->K: Loss of phosphatase activity."; /evidence="ECO:0000269|PubMed:7681221"; MUTAGEN 295; /note="R->A: Loss of phosphatase activity. Loss of phosphatase activity; when associated with A-292 and A-294. Does not affect interaction with MAPK1."; /evidence="ECO:0000269|PubMed:7681221"; MUTAGEN 295; /note="R->K: Loss of phosphatase activity."; /evidence="ECO:0000269|PubMed:7681221
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16288922
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7681221
uniprot
proteins
pubmed
7896276
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins