MRPL58
entrez
3396
canonical
uniprot
Q14197
canonical
ensembl
ENSG00000167862
resolver
ensp
ENSP00000301585
resolver
ensp
ENSP00000760525
resolver
enst
ENST00000301585
resolver
genesymbol
MRPL58
resolver
genesymbol_syn
DS1
resolver
genesymbol_syn
ICT1
resolver
hgnc
HGNC:5359
resolver
uniprot
B2RAD1
resolver
uniprot
Q53HM7
resolver
uniprot
Q53Y11
resolver
uniprot_entry
ICT1_HUMAN
resolver
uniprot_sec
B2RAD1
resolver
uniprot_sec
Q53HM7
resolver
uniprot_sec
Q53Y11
resolver
amino_acid_sequence
MAATRCLRWGLSRAGVWLLPPPARCPRRALHKQKDGTEFKSIYSLDKLYPESQGSDTAWRVPNGAKQADSDIPLDRLTISYCRSSGPGGQNVNKVNSKAEVRFHLATAEWIAEPVRQKIAITHKNKINRLGELILTSESSRYQFRNLADCLQKIRDMITEASQTPKEPTKEDVKLHRIRIENMNRERLRQKRIHSAVKTSRRVDMD
uniprot
proteins
ec_number
3.1.1.29
uniprot
proteins
function
FUNCTION: Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit (PubMed:20186120, PubMed:33878294). Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation (PubMed:33878294). Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (PubMed:20186120, PubMed:33878294). {ECO:0000269|PubMed:20186120, ECO:0000269|PubMed:33878294}.
uniprot
proteins
mass_dalton
23630
uniprot
proteins
mutagenesis
MUTAGEN 88; /note="G->A: Strongly impairs peptide release activity."; /evidence="ECO:0000269|PubMed:20186120"; MUTAGEN 89; /note="G->S: Strongly impairs peptide release activity."; /evidence="ECO:0000269|PubMed:20186120
uniprot
proteins
post_translational_modification
PTM: Methylation of glutamine in the GGQ triplet by HEMK1. {ECO:0000269|PubMed:35260756}.
uniprot
proteins
protein_family
Mitochondrion-specific ribosomal protein mL62 subfamily
uniprot
proteins
protein_family
Prokaryotic/mitochondrial release factor family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20186120
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23908630
uniprot
proteins
pubmed
24352605
uniprot
proteins
pubmed
25278503
uniprot
proteins
pubmed
25838379
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27023846
uniprot
proteins
pubmed
28892042
uniprot
proteins
pubmed
33878294
uniprot
proteins
pubmed
35177605
uniprot
proteins
pubmed
35260756
uniprot
proteins
pubmed
37141370
uniprot
proteins
pubmed
8575443
uniprot
proteins
sequence_length
206
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20186120, ECO:0000269|PubMed:23908630, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
uniprot
proteins