GPR32
entrez
2854
canonical
uniprot
O75388
canonical
ensembl
ENSG00000142511
resolver
ensp
ENSP00000270590
resolver
enst
ENST00000270590
resolver
genesymbol
GPR32
resolver
hgnc
HGNC:4487
resolver
uniprot
Q502U7
resolver
uniprot
Q6NWS5
resolver
uniprot_entry
GPR32_HUMAN
resolver
uniprot_sec
Q502U7
resolver
uniprot_sec
Q6NWS5
resolver
amino_acid_sequence
MNGVSEGTRGCSDRQPGVLTRDRSCSRKMNSSGCLSEEVGSLRPLTVVILSASIVVGVLGNGLVLWMTVFRMARTVSTVCFFHLALADFMLSLSLPIAMYYIVSRQWLLGEWACKLYITFVFLSYFASNCLLVFISVDRCISVLYPVWALNHRTVQRASWLAFGVWLLAAALCSAHLKFRTTRKWNGCTHCYLAFNSDNETAQIWIEGVVEGHIIGTIGHFLLGFLGPLAIIGTCAHLIRAKLLREGWVHANRPKRLLLVLVSAFFIFWSPFNVVLLVHLWRRVMLKEIYHPRMLLILQASFALGCVNSSLNPFLYVFVGRDFQEKFFQSLTSALARAFGEEEFLSSCPRGNAPRE
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that binds to several ligands including resolvin D1 (RvD1) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. In macrophages, enhances the RvD1-stimulated phagocytic and clearance functions (PubMed:20080636). Macrophages migrate less toward different chemoattractant stimuli but phagocytose more microbial particles (PubMed:26969756). Prevents the increase in Ca(2+) and activation of ERK1/2 used by histamine and its H1 receptor subtype to induce goblet cell secretion by activating PKC and GRK2 to counter-regulate the histamine receptor (PubMed:23462912). {ECO:0000269|PubMed:20080636, ECO:0000269|PubMed:23462912, ECO:0000269|PubMed:26969756}.
uniprot
proteins
mass_dalton
40087
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20080636
uniprot
proteins
pubmed
23462912
uniprot
proteins
pubmed
26969756
uniprot
proteins
pubmed
9653656
uniprot
proteins
sequence_length
356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 45..67; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 79..100; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 157..178; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 221..241; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 258..280; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 301..320; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins