Tmem150c
entrez
231503
canonical
uniprot
Q8C8S3
canonical
ensembl
ENSMUSG00000050640
resolver
ensp
ENSMUSP00000057116
resolver
ensp
ENSMUSP00000178627
resolver
ensp
ENSMUSP00000178629
resolver
ensp
ENSMUSP00000178634
resolver
ensp
ENSMUSP00000178645
resolver
genesymbol
Tmem150c
resolver
genesymbol_syn
Ttn3
resolver
uniprot
D3YVG3
resolver
uniprot
Q3TL78
resolver
uniprot
Q8K117
resolver
uniprot_entry
T150C_MOUSE
resolver
uniprot_sec
D3YVG3
resolver
uniprot_sec
Q3TL78
resolver
uniprot_sec
Q8K117
resolver
amino_acid_sequence
MDGKKCSVWMFLPLVFTLFTSAGLWIVYFIAVEDDKILPLNSAARKSGAKHAPYISFAGDDPPASCVFSQVMNMAAFLALVVAVLRFIQLKPKVLNPWLNISGLAALCLASFGMTLLGNFQLTNDEEIHNVGTSLTFGFGTLTCWIQAALTLKVNIKNEGRRAGIPRVILSAVITLCVVLYFILMAQDIHMYAARVQWGLVMCFLAYFGTLAVEFRHYRYEIVCSEYQENFLSFSESLSEASEYQTDQV
uniprot
proteins
function
FUNCTION: Nonselective cationic channel with high permeability to Ca(2+) (PubMed:27321926). Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception (PubMed:27321926). {ECO:0000269|PubMed:27321926}.
uniprot
proteins
mass_dalton
27759
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="G->A: Does not affect ion selectivity."; /evidence="ECO:0000269|PubMed:28426962"; MUTAGEN 48; /note="G->F: Does not affect ion selectivity."; /evidence="ECO:0000269|PubMed:28426962"; MUTAGEN 49; /note="A->K: Affects ion selectivity."; /evidence="ECO:0000269|PubMed:28426962"; MUTAGEN 50; /note="K->E: Does not affect ion selectivity."; /evidence="ECO:0000269|PubMed:28426962"; MUTAGEN 51; /note="H->D: Affects ion selectivity."; /evidence="ECO:0000269|PubMed:28426962
uniprot
proteins
protein_family
DRAM/TMEM150 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27321926
uniprot
proteins
pubmed
28426961
uniprot
proteins
pubmed
28426962
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27321926}; Multi-pass membrane protein {ECO:0000250|UniProtKB:B9EJG8}. Lysosome membrane {ECO:0000250|UniProtKB:B9EJG8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:B9EJG8}. Note=Localizes at the plasma membrane. A portion co-localizes with LAMP1 lysosomal marker. {ECO:0000250|UniProtKB:B9EJG8}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 65..85; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 98..118; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 131..151; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins