Efl1
entrez
101592
canonical
uniprot
Q8C0D5
canonical
ensembl
ENSMUSG00000038563
resolver
ensp
ENSMUSP00000046046
resolver
ensp
ENSMUSP00000137061
resolver
enst
ENSMUST00000039881
resolver
enst
ENSMUST00000179489
resolver
genesymbol
Efl1
resolver
genesymbol_syn
Eftud1
resolver
uniprot
Q80W46
resolver
uniprot
Q8C198
resolver
uniprot
Q8K0B8
resolver
uniprot_entry
EFL1_MOUSE
resolver
uniprot_sec
Q80W46
resolver
uniprot_sec
Q8C198
resolver
uniprot_sec
Q8K0B8
resolver
activity_regulation
ACTIVITY REGULATION: GTPase activity is stimulated in the presence of 60S ribosome subunits. {ECO:0000250|UniProtKB:Q7Z2Z2}.
uniprot
proteins
amino_acid_sequence
MVLSGVDKMIRLQKNTANIRNICVLAHVDHGKTTLADCLISSNGIISSRLAGKLRYMDSREDEQVRGITMKSSAISLHYAEGHEEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVLEERAERETESQAKPHSEQGEQVYDWSAGLEDVDDSQLYFSPEQGNVVFTSAIDGWGFGIEHFARIYSQKIGIKKEVLLKTLWGDYYINMKAKKIMKVDQAKGKKPLFVQLILENIWSLYDAVLKKDKEKIDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISHAVLAMVCHKLPSPLDMTSERVEKLLCTGSQTFESLPPETQALKAAFMKCGSEDTAPVIIFVSKMFAVDVKALPQNKPRPLTQEEMAQRRERARQRHAEKLAAAQGQTSQGPTQDGGALETSPHEDEPRGDEPDVASVSRQPVSQEESSQEAFIAFARVFSGIARRGKKIFVLGPKYSPVDFLQRVPLGFSAPLEDLPPVPHMACCTLENLYLLMGRELEDLEEVPPGNVLGIGGLQDFVLKSATLCSLPSCPPFIPLNFEATPIVRVAVEPKHPSEMPQLVKGMKLLNQADPCVQVLIQETGEHVLVTAGEVHLQRCLDDLRERFAKIHISVSEPIIPFRETITKPPKVDMVNEEIGRQQKVAVIHQTKEEQSKIPEGIHVDSDGLITIPTPNKLATLSVRAIPLPEEVTRILEENSDLIRSMELLTSSLNEGRNTQAIHQKTQEKIWEFKGKLEKHLTGRKWRNTVDQIWSFGPRKCGPNILVSRSEDFQNSVWSGPAGRESKEASRFRDFGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWELNKCAEQGASDKQHQGQCDLAGEGQGGGKTCHVGDENQEQQDVCSEPFEETSQKGDSPVIDCYGPFSGQLIATMKEACRYALQVKPQRLMAAMYTCDIMATSDVLGRVYAVLSKREGRVLQEEMKEGTDMFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEVIPSDPFWVPTTEEEYLHFGEKADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSKNK
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. {ECO:0000250|UniProtKB:Q7Z2Z2}.
uniprot
proteins
mass_dalton
125777
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1127
uniprot
proteins