Satb2
entrez
212712
canonical
uniprot
Q8VI24
canonical
ensembl
ENSMUSG00000038331
resolver
ensp
ENSMUSP00000110057
resolver
ensp
ENSMUSP00000253435
resolver
ensp
ENSMUSP00000253437
resolver
genesymbol
Satb2
resolver
genesymbol_syn
Kiaa1034
resolver
genesymbol_syn
SATB2
resolver
uniprot
Q546B3
resolver
uniprot_entry
Q546B3_MOUSE
resolver
uniprot_entry
SATB2_MOUSE
resolver
amino_acid_sequence
MERRSESPCLRDSPDRRSGSPDVKGPPPVKVARLEQNGSPMGARGRPNGAVAKAVGGLMIPVFCVVEQLDGSLEYDNREEHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKLGRWNPLPLSYVTDAPDATVADMLQDVYHVVTLKIQLQSCSKLEDLPAEQWNHATVRNALKELLKEMNQSTLAKECPLSQSMISSIVNSTYYANVSATKCQEFGRWYKKYKKIKVERVERENLSDYCVLGQRPMHLPNMNQLASLGKTNEQSPHSQIHHSTPIRNQVPALQPIMSPGLLSPQLSPQLVRQQIAMAHLINQQIAVSRLLAHQHPQAINQQFLNHPPIPRAVKPEPTNSSVEVSPDIYQQVRDELKRASVSQAVFARVAFNRTQGLLSEILRKEEDPRTASQSLLVNLRAMQNFLNLPEVERDRIYQDERERSMNPNVSMVSSASSSPSSSRTPQAKTSTPTTDLPIKVDGANVNITAAIYDEIQQEMKRAKVSQALFAKVAANKSQGWLCELLRWKENPSPENRTLWENLCTIRRFLNLPQHERDVIYEEESRHHHSERMQHVVQLPPEPVQVLHRQQSQPTKESSPPREEAPPPPPPTEDSCAKKPRSRTKISLEALGILQSFIHDVGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVKHHGKLKEHLGSAVDVAEYKDEELLTESEENDSEEGSEEMYKVEAEEENADKSKAAPAETDQR
uniprot
proteins
function
FUNCTION: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating Bcl11b expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:16751105, ECO:0000269|PubMed:18255030, ECO:0000269|PubMed:18255031}.
uniprot
proteins
mass_dalton
82559
uniprot
proteins
post_translational_modification
PTM: Sumoylated by PIAS1. Sumoylation promotes nuclear localization, but represses transcription factor activity (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
CUT homeobox family
uniprot
proteins
pubmed
12915443
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
16751105
uniprot
proteins
pubmed
18255030
uniprot
proteins
pubmed
18255031
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
733
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00374}.
uniprot
proteins