Id3
entrez
15903
canonical
uniprot
P41133
canonical
ensembl
ENSMUSG00000007872
resolver
ensp
ENSMUSP00000008016
resolver
enst
ENSMUST00000008016
resolver
genesymbol
Id3
resolver
genesymbol_syn
Hlh462
resolver
genesymbol_syn
Id-3
resolver
genesymbol_syn
Idb3
resolver
uniprot
Q545W1
resolver
uniprot_entry
ID3_MOUSE
resolver
uniprot_entry
Q545W1_MOUSE
resolver
amino_acid_sequence
MKALSPVRGCYEAVCCLSERSLAIARGRGKSPSTEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTAELTPELVISKDKRSFCH
uniprot
proteins
function
FUNCTION: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:19217292, ECO:0000269|PubMed:22862948, ECO:0000269|PubMed:23824195}.
uniprot
proteins
mass_dalton
13089
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated; which is favored by Ifi204 and leads to proteasomal degradation. {ECO:0000269|PubMed:16556596}.
uniprot
proteins
pubmed
11940648
uniprot
proteins
pubmed
15451666
uniprot
proteins
pubmed
16556596
uniprot
proteins
pubmed
19217292
uniprot
proteins
pubmed
2000388
uniprot
proteins
pubmed
22862948
uniprot
proteins
pubmed
23824195
uniprot
proteins
sequence_length
119
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:16556596}. Cytoplasm {ECO:0000269|PubMed:16556596}. Note=Nuclear in proliferating cells, translocates to cytosol during cell differentiation.
uniprot
proteins