PILRA
entrez
29992
canonical
uniprot
Q9UKJ1
canonical
ensembl
ENSG00000085514
resolver
ensp
ENSP00000198536
resolver
ensp
ENSP00000340109
resolver
ensp
ENSP00000377569
resolver
ensp
ENSP00000773422
resolver
genesymbol
PILRA
resolver
hgnc
HGNC:20396
resolver
uniprot
Q8NHI1
resolver
uniprot_entry
PILRA_HUMAN
resolver
uniprot_sec
Q8NHI1
resolver
amino_acid_sequence
MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQAVTTTTQRPSSMTTTWRLSSTTTTTGLRVTQGKRRSDSWHISLETAVGVAVAVTVLGIMILGLICLLRWRRRKGQQRTKATTPAREPFQNTEEPYENIRNEGQNTDPKLNPKDDGIVYASLALSSSTSPRAPPSHRPLKSPQNETLYSVLKA
uniprot
proteins
function
FUNCTION: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. {ECO:0000269|PubMed:10903717, ECO:0000269|PubMed:21241660}.; FUNCTION: (Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1. {ECO:0000269|PubMed:18358807}.
uniprot
proteins
mass_dalton
34005
uniprot
proteins
mutagenesis
MUTAGEN 269; /note="Y->F: Greatly diminishes interaction with PTPN6."; /evidence="ECO:0000269|PubMed:10660620
uniprot
proteins
post_translational_modification
PTM: According to PubMed:10660620, N- and O-glycosylated. According to PubMed:10903717, only N-glycosylated. {ECO:0000269|PubMed:10660620, ECO:0000269|PubMed:10903717, ECO:0000269|PubMed:19159218}.; PTM: Phosphorylated on tyrosine residues. {ECO:0000269|PubMed:10660620, ECO:0000269|PubMed:10903717}.
uniprot
proteins
pubmed
10660620
uniprot
proteins
pubmed
10903717
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18358807
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21241660
uniprot
proteins
sequence_length
303
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 198..218; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins