P41234
uniprot
P41234
canonical
amino_acid_sequence
MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEAFYTAAPLTSAGILPVMQSLCPDGQRDEFGFLQYANSTVTQLLERLHRVVEEGNLFDPVRPSLGSELEALRQRLEALSSGPGTWESHSARPAVSSFSLDSVARDQRELWRFLMQNLSLPNSTAQALLAARVDPSEVYRLLFGPLPDLDGKLGFLRKQEPWSRLGSNPLLQMEELLLAPALLEQLTCAPGSGELGRILTMPEGHQVDLQGYRDAVCSGQATARAQRFSDLAAELRNQLDTAKIAQQLGFDVPNGSDPQPQAPSPQSLPALLGDLLDAQKLLQDVDVLSALALLLPQGACAGQASAPQASSLNGLANSTGIGANSGSNTTVEEGTQSPVSPASPDTLQGQCSAFVQLWAGLQPILCGNNRTIEPEALRRGNMSSLGFTSKEQRNLGLLVHLMTSNPKILYAPVGSEADRVILKANETFAFVGNVTHYAQVWLNISTEIRSFLEQGRLQQHLQWLQQYVADLQLHPEAMNLSLEELPPALRQDFSLPNGTALLQQLDTIDNAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGLRLDQDMMERAIINTFVGHDVVEPGNYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYCQVLMHSHVLIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASRCPQQPLAWVPSTLHCMKWQEWASIQWHTFSQSPVEGDDFNLLLAVTMLMVDTVVYGVLTWYIEAVHPGMYGLPRPWYSRYRSPIGWAVGGQKPGSGAGHGHTHRASALWRRIQACAMESRHFEETRGMEEEPTHLPLVVCVDKLTKVYKNDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRKETDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGAYGDGYRLTLVKQPAEPGTSQEPGLASSPSGCPRLSSCSEPQVSQFIRKHVASSLLVSDTSTELSYILPSEAVKKGAFERLFQQLEHSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDVLPGAEGLTAVGGQAGNLARCSELAQSQASLQSASSVGSARGEEGTGYSDGYGDYRPLFDNLQDPDNVSLQEAEMEALAQVGQGSRKLEGWWLKMRQFHGLLVKRFHCARRNSKALCSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEERQEYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPMLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPVSPDEDSLQAWNMSLPPTAGPETWTSAPSLPRLVHEPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRLHRYGAITFGNVQKSIPASFGARVPPMVRKIAVRRVAQVLYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPVIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMTVEGFVGFFLTIMCQYNFLRQPQRLPVSTKPVEDDVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKDLLQVQQSLGYCPQFDALFDELTAREHLQLYTRLRGIPWKDEAQVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQNVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVVGVLGIEDYSVSQTTLDNVFVNFAKKQSDNVEQQEAEPSSLPSPLGLLSLLRPRPAPTELRALVADEPEDLDTEDEGLISFEEERAQLSFNTDTLC
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
function
FUNCTION: Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (PubMed:17488728, PubMed:22748276). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (By similarity). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926). May play a role in myelin formation (PubMed:17060448). {ECO:0000250|UniProtKB:Q9BZC7, ECO:0000269|PubMed:17060448, ECO:0000269|PubMed:17488728, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:22748276}.
uniprot
proteins
mass_dalton
270509
uniprot
proteins
post_translational_modification
PTM: Methylated at Gln-271 by N6AMT1. {ECO:0000250|UniProtKB:Q9BZC7}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCA family
uniprot
proteins
pubmed
11157071
uniprot
proteins
pubmed
17060448
uniprot
proteins
pubmed
17488728
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22086926
uniprot
proteins
pubmed
22748276
uniprot
proteins
pubmed
8088782
uniprot
proteins
sequence_length
2434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q9BZC7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BZC7}. Lysosome membrane {ECO:0000269|PubMed:11157071}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BZC7}. Note=Forms discrete, punctate intracellular vesicles. {ECO:0000250|UniProtKB:Q9BZC7}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 54..74; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 698..718; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 749..769; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 781..801; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 812..832; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 893..913; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1461..1481; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1793..1813; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1842..1862; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1873..1893; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1906..1926; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1992..2012; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins