NUBP2
entrez
10101
canonical
uniprot
Q9Y5Y2
canonical
ensembl
ENSG00000095906
resolver
ensp
ENSP00000262302
resolver
ensp
ENSP00000455896
resolver
ensp
ENSP00000460079
resolver
ensp
ENSP00000687514
resolver
enst
ENST00000262302
resolver
enst
ENST00000565987
resolver
enst
ENST00000568706
resolver
genesymbol
NUBP2
resolver
hgnc
HGNC:8042
resolver
uniprot
B7Z6P0
resolver
uniprot
D3DU80
resolver
uniprot
H3BQR2
resolver
uniprot
I3L307
resolver
uniprot
Q9NWB2
resolver
uniprot_entry
B7Z6P0_HUMAN
resolver
uniprot_entry
H3BQR2_HUMAN
resolver
uniprot_entry
I3L307_HUMAN
resolver
uniprot_entry
NUBP2_HUMAN
resolver
uniprot_sec
D3DU80
resolver
uniprot_sec
Q9NWB2
resolver
amino_acid_sequence
MEAAAEPGNLAGVRHIILVLSGKGGVGKSTISTELALALRHAGKKVGILDVDLCGPSIPRMLGAQGRAVHQCDRGWAPVFLDREQSISLMSVGFLLEKPDEAVVWRGPKKNALIKQFVSDVAWGELDYLVVDTPPGTSDEHMATIEALRPYQPLGALVVTTPQAVSVGDVRRELTFCRKTGLRVMGIVENMSGFTCPHCTECTSVFSRGGGEELAQLAGVPFLGSVPLDPALMRTLEEGHDFIQEFPGSPAFAALTSIAQKILDATPACLP
uniprot
proteins
function
FUNCTION: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure. {ECO:0000250|UniProtKB:Q9R061, ECO:0000255|HAMAP-Rule:MF_03039}.
uniprot
proteins
mass_dalton
28825
uniprot
proteins
protein_family
Mrp/NBP35 ATP-binding proteins family
uniprot
proteins
protein_family
NUBP2/CFD1 subfamily
uniprot
proteins
pubmed
10486206
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18573874
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29848660
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03039}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03039}. Cytoplasm {ECO:0000269|PubMed:29848660}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9R061}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9R061}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q9R061}. Note=Enriched at the centrosomes during mitosis. Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis (By similarity). Localized at centrioles and in the nucleus at interphase (By similarity). Colocalizes with nubp-1 at prometaphase (By similarity). {ECO:0000250|UniProtKB:Q9R061, ECO:0000255|HAMAP-Rule:MF_03039}.
uniprot
proteins