DNAJB14
entrez
79982
canonical
uniprot
Q8TBM8
canonical
ensembl
ENSG00000164031
resolver
ensp
ENSP00000404381
resolver
ensp
ENSP00000480565
resolver
ensp
ENSP00000623855
resolver
enst
ENST00000610281
resolver
genesymbol
DNAJB14
resolver
hgnc
HGNC:25881
resolver
uniprot
A0A087WWX2
resolver
uniprot
Q6UXN1
resolver
uniprot
Q7Z3P0
resolver
uniprot
Q86TA7
resolver
uniprot
Q86TM0
resolver
uniprot
Q9GZU9
resolver
uniprot_entry
A0A087WWX2_HUMAN
resolver
uniprot_entry
DJB14_HUMAN
resolver
uniprot_sec
Q6UXN1
resolver
uniprot_sec
Q7Z3P0
resolver
uniprot_sec
Q86TA7
resolver
uniprot_sec
Q86TM0
resolver
uniprot_sec
Q9GZU9
resolver
amino_acid_sequence
MEGNRDEAEKCVEIAREALNAGNREKAQRFLQKAEKLYPLPSARALLEIIMKNGSTAGNSPHCRKPSGSGDQSKPNCTKDSTSGSGEGGKGYTKDQVDGVLSINKCKNYYEVLGVTKDAGDEDLKKAYRKLALKFHPDKNHAPGATDAFKKIGNAYAVLSNPEKRKQYDLTGNEEQACNHQNNGRFNFHRGCEADITPEDLFNIFFGGGFPSGSVHSFSNGRAGYSQQHQHRHSGHEREEERGDGGFSVFIQLMPIIVLILVSLLSQLMVSNPPYSLYPRSGTGQTIKMQTENLGVVYYVNKDFKNEYKGMLLQKVEKSVEEDYVTNIRNNCWKERQQKTDMQYAAKVYRDDRLRRKADALSMDNCKELERLTSLYKGG
uniprot
proteins
function
FUNCTION: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). {ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744). {ECO:0000269|PubMed:21673190, ECO:0000269|PubMed:24675744}.
uniprot
proteins
mass_dalton
42516
uniprot
proteins
mutagenesis
MUTAGEN 136; /note="H->Q: Abolishes interaction with HSPA8/Hsc70."; /evidence="ECO:0000269|PubMed:24732912
uniprot
proteins
protein_family
DNAJB12/DNAJB14 subfamily
uniprot
proteins
protein_family
DnaJ family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21673190
uniprot
proteins
pubmed
23018488
uniprot
proteins
pubmed
24675744
uniprot
proteins
pubmed
24732912
uniprot
proteins
pubmed
25631089
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27916661
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000269|PubMed:24732912}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to the endoplasmic reticulum membrane (PubMed:23018488, PubMed:24732912, PubMed:27916661). When overexpressed, forms membranous structures in the nucleus (PubMed:24732912). {ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; SUBCELLULAR LOCATION: Note=(Microbial infection) Upon SV40 infection, colocalizes with BCAP31, DNAJB12 and DNAJC18 in punctate structures within the endoplasmic reticulum membrane. {ECO:0000269|PubMed:25631089}.
uniprot
proteins
transmembrane_region
TRANSMEM 245..265; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins