Rgs7
entrez
24012
canonical
uniprot
O54829
canonical
ensembl
ENSMUSG00000026527
resolver
ensp
ENSMUSP00000027812
resolver
ensp
ENSMUSP00000141380
resolver
ensp
ENSMUSP00000142180
resolver
ensp
ENSMUSP00000142278
resolver
enst
ENSMUST00000027812
resolver
enst
ENSMUST00000192227
resolver
enst
ENSMUST00000194555
resolver
enst
ENSMUST00000195324
resolver
genesymbol
Rgs7
resolver
uniprot
A0A0A6YW36
resolver
uniprot
A0A0A6YXX4
resolver
uniprot
E9QLB9
resolver
uniprot
Q80XD3
resolver
uniprot_entry
A0A0A6YW36_MOUSE
resolver
uniprot_entry
A0A0A6YXX4_MOUSE
resolver
uniprot_entry
Q80XD3_MOUSE
resolver
uniprot_entry
RGS7_MOUSE
resolver
uniprot_sec
E9QLB9
resolver
amino_acid_sequence
MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELHQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYVEYDPFLVPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKRRPIREVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKRKGKTLTSKRLTSLVQSY
uniprot
proteins
function
FUNCTION: GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades (PubMed:25792749). The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form (By similarity). May play a role in synaptic vesicle exocytosis (By similarity). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (PubMed:30546127, PubMed:31311860). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (By similarity). {ECO:0000250|UniProtKB:P49802, ECO:0000269|PubMed:25792749, ECO:0000269|PubMed:30546127, ECO:0000269|PubMed:31311860}.
uniprot
proteins
mass_dalton
54792
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. {ECO:0000250|UniProtKB:O46470}.; PTM: Ubiquitinated, leading to rapid proteasomal degradation. {ECO:0000250|UniProtKB:P49802}.; PTM: Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity. {ECO:0000250|UniProtKB:P49802}.
uniprot
proteins
pubmed
10862767
uniprot
proteins
pubmed
15632198
uniprot
proteins
pubmed
15897264
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22689652
uniprot
proteins
pubmed
25792749
uniprot
proteins
pubmed
30546127
uniprot
proteins
pubmed
31311860
uniprot
proteins
pubmed
9459445
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49802}. Cytoplasm {ECO:0000250|UniProtKB:P49802}. Cell membrane {ECO:0000269|PubMed:22689652, ECO:0000269|PubMed:25792749, ECO:0000269|PubMed:30546127}. Membrane {ECO:0000250|UniProtKB:P49802}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49802}; Cytoplasmic side {ECO:0000250|UniProtKB:P49802}. Note=Interaction with PKD1 promotes location at the cell membrane. Interaction with RGS7BP promotes location at the cell membrane. {ECO:0000250|UniProtKB:P49802}.
uniprot
proteins