Syce3
entrez
75459
canonical
uniprot
B5KM66
canonical
ensembl
ENSMUSG00000078938
resolver
ensp
ENSMUSP00000104937
resolver
ensp
ENSMUSP00000131766
resolver
enst
ENSMUST00000109314
resolver
enst
ENSMUST00000167959
resolver
genesymbol
Syce3
resolver
genesymbol_syn
Tseg2
resolver
uniprot
E7D6R1
resolver
uniprot_entry
E7D6R1_MOUSE
resolver
uniprot_entry
SYCE3_MOUSE
resolver
amino_acid_sequence
MADSDPGERSYDNMLKMLSDLNKDLEKLLEEMEKISVQATWMAYDMVVMRTNPTLAESMRRLEDAFLNCKEEMEKNWQELLTETKRKQ
uniprot
proteins
function
FUNCTION: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:21637789, PubMed:36635604). Required for the assembly of the central element of the synaptonemal complex during meiosis, via remodeling of SYCP1 lattice structures and promoting recruitment of SYCE2-TEX12 and SYCE1-SIX60S1 complexes (By similarity). Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes (PubMed:21637789). Chromosome loading appears to require SYCP1 (PubMed:21637789). Required for fertility and normal testis development (PubMed:21637789, PubMed:36635604). May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism (PubMed:20407872). {ECO:0000250|UniProtKB:A1L190, ECO:0000269|PubMed:20407872, ECO:0000269|PubMed:21637789, ECO:0000269|PubMed:36635604}.
uniprot
proteins
mass_dalton
10467
uniprot
proteins
pubmed
19323366
uniprot
proteins
pubmed
20407872
uniprot
proteins
pubmed
21637789
uniprot
proteins
pubmed
25394919
uniprot
proteins
pubmed
30949703
uniprot
proteins
pubmed
31437213
uniprot
proteins
pubmed
36635604
uniprot
proteins
sequence_length
88
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21637789}. Chromosome {ECO:0000269|PubMed:21637789, ECO:0000269|PubMed:30949703}. Note=Colocalizes with SYCE1 in the central elements. {ECO:0000269|PubMed:21637789}.
uniprot
proteins