Bag5
entrez
70369
canonical
uniprot
Q8CI32
canonical
ensembl
ENSMUSG00000049792
resolver
ensp
ENSMUSP00000051049
resolver
ensp
ENSMUSP00000125183
resolver
ensp
ENSMUSP00000342522
resolver
enst
ENSMUST00000054636
resolver
enst
ENSMUST00000160576
resolver
genesymbol
Bag5
resolver
uniprot
Q3TVA8
resolver
uniprot
Q8K175
resolver
uniprot
Q9DAU0
resolver
uniprot_entry
BAG5_MOUSE
resolver
uniprot_sec
Q3TVA8
resolver
uniprot_sec
Q8K175
resolver
uniprot_sec
Q9DAU0
resolver
amino_acid_sequence
MDMGNQHPSISRLQEIQREVKAIEPQVVGFSGLSDDKNYKRLERILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQNANHPHRIEIQNIFKEAQALVKDKIVPFYSGGNCVTDEFEEGIQDIILRLTHVKTGGKVSLRKARYRTLTKICAVQEVIEDCMKKQPSLPLSEDVHPSVAKINSVMCEVNKARGTLIALLMGVDSSETCRHLSCVLSGLIADLDALDVCGRTEIRNYRREVVEDINKLLKYLDLEEEADSTHAFDLGQNHSIIKIENVLKRMREIKNELLQAQSPPELYLRAKTELQGLIGQLDEVSLEKNPCIREARRRAVIEVQILITYLDLKEALEKRKLFPCEEHPPHKAVWEILGNLSEILGEVLSFGGNRTDKNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVKLAQNILSYLDMKSDEWEY
uniprot
proteins
function
FUNCTION: Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding (By similarity). Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (PubMed:35044787). Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). {ECO:0000250|UniProtKB:Q5QJC9, ECO:0000250|UniProtKB:Q9UL15, ECO:0000269|PubMed:35044787}.
uniprot
proteins
mass_dalton
50943
uniprot
proteins
mutagenesis
MUTAGEN 197..447; /note="Missing: Results in lack of BAG5 at junctional membrane complexes in cardiomyocytes from homozygous mutant mice, disruption of junctional membrane complex structure, and calcium handling abnormalities. Homozygous mutant mice exhibit ventricular dilatation and arrhythmogenicity."; /evidence="ECO:0000269|PubMed:35044787
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20223214
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
35044787
uniprot
proteins
sequence_length
447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Note=In cardiomyocytes, localized at specialized membrane contact sites between T-tubules and the sarcoplasmic reticulum, known as junctional membrane complexes. {ECO:0000269|PubMed:35044787}.
uniprot
proteins