EZH1
entrez
2145
canonical
uniprot
Q92800
canonical
ensembl
ENSG00000108799
resolver
ensp
ENSP00000404658
resolver
ensp
ENSP00000407869
resolver
ensp
ENSP00000467871
resolver
enst
ENST00000415827
resolver
genesymbol
EZH1
resolver
genesymbol_syn
KIAA0388
resolver
hgnc
HGNC:3526
resolver
uniprot
A0A0A0MSY9
resolver
uniprot
A6NCH6
resolver
uniprot
B4DIJ1
resolver
uniprot
B4DIZ7
resolver
uniprot
B4DSS2
resolver
uniprot
B4E3R7
resolver
uniprot
O43287
resolver
uniprot
Q14459
resolver
uniprot
Q53XP3
resolver
uniprot_entry
A0A0A0MSY9_HUMAN
resolver
uniprot_entry
EZH1_HUMAN
resolver
uniprot_sec
A6NCH6
resolver
uniprot_sec
B4DIJ1
resolver
uniprot_sec
B4DIZ7
resolver
uniprot_sec
B4DSS2
resolver
uniprot_sec
B4E3R7
resolver
uniprot_sec
O43287
resolver
uniprot_sec
Q14459
resolver
uniprot_sec
Q53XP3
resolver
amino_acid_sequence
MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQNFMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELVDALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGRRRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILKLPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVL
uniprot
proteins
ec_number
2.1.1.356
uniprot
proteins
function
FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269|PubMed:19026781}.
uniprot
proteins
mass_dalton
85271
uniprot
proteins
mutagenesis
MUTAGEN 690; /note="H->A: Loss of methyltransferase activity."; /evidence="ECO:0000269|PubMed:19026781
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
EZ subfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19026781
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
31451685
uniprot
proteins
pubmed
7490091
uniprot
proteins
pubmed
8921387
uniprot
proteins
pubmed
9205841
uniprot
proteins
pubmed
9473645
uniprot
proteins
sequence_length
747
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19026781}. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.
uniprot
proteins