Emc10
entrez
69683
canonical
uniprot
Q3TAS6
canonical
ensembl
ENSMUSG00000008140
resolver
ensp
ENSMUSP00000113141
resolver
ensp
ENSMUSP00000113509
resolver
ensp
ENSMUSP00000159045
resolver
ensp
ENSMUSP00000178059
resolver
enst
ENSMUST00000239015
resolver
genesymbol
Emc10
resolver
genesymbol_syn
Hsm1
resolver
genesymbol_syn
Inm02
resolver
uniprot
A0A0X1KG67
resolver
uniprot
Q3TFU1
resolver
uniprot
Q5UCC3
resolver
uniprot
Q5UCC5
resolver
uniprot
Q8VCD8
resolver
uniprot
Q99JJ8
resolver
uniprot_entry
A0A0X1KG67_MOUSE
resolver
uniprot_entry
EMC10_MOUSE
resolver
uniprot_sec
Q3TFU1
resolver
uniprot_sec
Q5UCC3
resolver
uniprot_sec
Q5UCC5
resolver
uniprot_sec
Q8VCD8
resolver
uniprot_sec
Q99JJ8
resolver
amino_acid_sequence
MVAAGAGVTRLLVLLLMVAAAPSRARGSGCRVGASARGTGADGREAEGCGTVALLLEHSFELGDGANFQKRGLLLWNQQDGTLSATQRQLSEEERGRLRDVAAVNGLYRVRVPRRPGTLDGSEAGGHVSSFVPACSLVESHLSDQLTLHVDVAGNVVGLSVVVYPGGCRGSEVEDEDLELFNTSVQLRPPSTAPGPETAAFIERLEMEQAQKAKNPQEQKSFFAKYWMYIIPVVLFLMMSGAPDAGGQGGGGGGGSSR
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways (PubMed:28931551). {ECO:0000250|UniProtKB:Q5UCC4, ECO:0000269|PubMed:28931551}.
uniprot
proteins
mass_dalton
27053
uniprot
proteins
protein_family
EMC10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20680400
uniprot
proteins
pubmed
28931551
uniprot
proteins
sequence_length
258
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:28931551}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5UCC4}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q5UCC4}.
uniprot
proteins
transmembrane_region
TRANSMEM 222..242; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins