Il23a
entrez
83430
canonical
uniprot
Q9EQ14
canonical
ensembl
ENSMUSG00000025383
resolver
ensp
ENSMUSP00000026449
resolver
enst
ENSMUST00000026449
resolver
genesymbol
Il23a
resolver
uniprot_entry
IL23A_MOUSE
resolver
amino_acid_sequence
MLDCRAVIMLWLLPWVTQGLAVPRSSSPDWAQCQQLSRNLCMLAWNAHAPAGHMNLLREEEDEETKNNVPRIQCEDGCDPQGLKDNSQFCLQRIRQGLAFYKHLLDSDIFKGEPALLPDSPMEQLHTSLLGLSQLLQPEDHPRETQQMPSLSSSQQWQRPLLRSKILRSLQAFLAIAARVFAHGAATLTEPLVPTA
uniprot
proteins
function
FUNCTION: Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed:11114383, PubMed:11390512, PubMed:16670770). Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 (By similarity). This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A (PubMed:19900478). In turn, participates in the early and effective intracellular bacterial clearance (PubMed:16157683). Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells (PubMed:16648837). {ECO:0000250|UniProtKB:Q9NPF7, ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:11390512, ECO:0000269|PubMed:12610626, ECO:0000269|PubMed:12847224, ECO:0000269|PubMed:14662908, ECO:0000269|PubMed:14978083, ECO:0000269|PubMed:16157683, ECO:0000269|PubMed:16648837, ECO:0000269|PubMed:16670770, ECO:0000269|PubMed:16688182, ECO:0000269|PubMed:19900478}.
uniprot
proteins
mass_dalton
22071
uniprot
proteins
protein_family
IL-6 superfamily
uniprot
proteins
pubmed
11114383
uniprot
proteins
pubmed
11390512
uniprot
proteins
pubmed
11801672
uniprot
proteins
pubmed
12162874
uniprot
proteins
pubmed
12417590
uniprot
proteins
pubmed
12610626
uniprot
proteins
pubmed
12847224
uniprot
proteins
pubmed
14568135
uniprot
proteins
pubmed
14662908
uniprot
proteins
pubmed
14978083
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16157683
uniprot
proteins
pubmed
16339539
uniprot
proteins
pubmed
16648837
uniprot
proteins
pubmed
16670770
uniprot
proteins
pubmed
16688182
uniprot
proteins
pubmed
19900478
uniprot
proteins
sequence_length
196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11114383}. Note=Secreted upon association with IL12B.
uniprot
proteins