Faslg
entrez
25385
canonical
uniprot
P36940
canonical
ensembl
ENSRNOG00000002978
resolver
ensembl
ENSRNOG00055017740
resolver
ensembl
ENSRNOG00060008590
resolver
ensembl
ENSRNOG00065019821
resolver
ensp
ENSRNOP00000003998
resolver
ensp
ENSRNOP00055024103
resolver
ensp
ENSRNOP00060011006
resolver
ensp
ENSRNOP00065026716
resolver
enst
ENSRNOT00000003998
resolver
enst
ENSRNOT00055030011
resolver
enst
ENSRNOT00060014329
resolver
enst
ENSRNOT00065033401
resolver
genesymbol
Faslg
resolver
genesymbol_syn
Apt1Lg1
resolver
genesymbol_syn
Cd95l
resolver
genesymbol_syn
Fasl
resolver
genesymbol_syn
Tnfsf6
resolver
genesymbol_syn
Tnlg1a
resolver
uniprot
A0A0U5J7X8
resolver
uniprot_entry
A0A0U5J7X8_RAT
resolver
uniprot_entry
TNFL6_RAT
resolver
amino_acid_sequence
MQQPVNYPCPQIYWVDSSATSPWAPPGSVFSCPSSGPRGPGQRRPPPPPPPPSPLPPPSQPPPLPPLSPLKKKDNIELWLPVIFFMVLVALVGMGLGMYQLFHLQKELAELREFTNHSLRVSSFEKQIANPSTPSETKKPRSVAHLTGNPRSRSIPLEWEDTYGTALISGVKYKKGGLVINEAGLYFVYSKVYFRGQSCNSQPLSHKVYMRNFKYPGDLVLMEEKKLNYCTTGQIWAHSSYLGAVFNLTVADHLYVNISQLSLINFEESKTFFGLYKL
uniprot
proteins
function
FUNCTION: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:7505205). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:7505205). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis also has a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (By similarity). {ECO:0000250|UniProtKB:P41047, ECO:0000250|UniProtKB:P48023, ECO:0000269|PubMed:7505205}.; FUNCTION: [Tumor necrosis factor ligand superfamily member 6, soluble form]: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process. {ECO:0000250|UniProtKB:P41047}.; FUNCTION: [FasL intracellular domain]: Cytoplasmic form induces gene transcription inhibition. {ECO:0000250|UniProtKB:P48023}.
uniprot
proteins
mass_dalton
31140
uniprot
proteins
post_translational_modification
PTM: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells. {ECO:0000250|UniProtKB:P48023}.; PTM: Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization. {ECO:0000250|UniProtKB:P48023}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:P48023}.; PTM: Monoubiquitinated. {ECO:0000250|UniProtKB:P48023}.
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
7505205
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7505205}; Single-pass type II membrane protein {ECO:0000255}. Cytoplasmic vesicle lumen {ECO:0000250|UniProtKB:P48023}. Lysosome lumen {ECO:0000250|UniProtKB:P48023}. Note=Colocalizes with the SPPL2A protease at the cell membrane. Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. {ECO:0000250|UniProtKB:P48023}.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted {ECO:0000250|UniProtKB:P48023}. Note=May be released into the extracellular fluid by cleavage from the cell surface. {ECO:0000250|UniProtKB:P48023}.; SUBCELLULAR LOCATION: [FasL intracellular domain]: Nucleus {ECO:0000250|UniProtKB:P48023}. Note=The FasL ICD cytoplasmic form is translocated into the nucleus. {ECO:0000250|UniProtKB:P48023}.
uniprot
proteins
transmembrane_region
TRANSMEM 78..99; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins