Psma2
entrez
19166
canonical
uniprot
P49722
canonical
ensembl
ENSMUSG00000015671
resolver
ensp
ENSMUSP00000129767
resolver
enst
ENSMUST00000170836
resolver
genesymbol
Psma2
resolver
genesymbol_syn
Lmpc3
resolver
uniprot
E9Q3A4
resolver
uniprot
Q6ZWV8
resolver
uniprot_entry
PSA2_MOUSE
resolver
uniprot_sec
E9Q3A4
resolver
uniprot_sec
Q6ZWV8
resolver
amino_acid_sequence
MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVRDYLAAIA
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:16581775, ECO:0000269|PubMed:22341445}.
uniprot
proteins
mass_dalton
25927
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues; which may be important for nuclear import. {ECO:0000250|UniProtKB:P17220}.
uniprot
proteins
protein_family
Peptidase T1A family
uniprot
proteins
pubmed
10436176
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16581775
uniprot
proteins
pubmed
16857966
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22078707
uniprot
proteins
pubmed
22341445
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7697131
uniprot
proteins
sequence_length
234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22078707}. Nucleus {ECO:0000269|PubMed:22078707}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (By similarity). Colocalizes with TRIM5 in cytoplasmic bodies (PubMed:22078707). {ECO:0000250|UniProtKB:P25787, ECO:0000269|PubMed:22078707}.
uniprot
proteins