HSPH1
entrez
10808
canonical
uniprot
Q92598
canonical
ensembl
ENSG00000120694
resolver
ensp
ENSP00000318687
resolver
ensp
ENSP00000369768
resolver
ensp
ENSP00000396090
resolver
ensp
ENSP00000487365
resolver
ensp
ENSP00000624062
resolver
ensp
ENSP00000624065
resolver
enst
ENST00000445273
resolver
genesymbol
HSPH1
resolver
genesymbol_syn
HSP105
resolver
genesymbol_syn
HSP110
resolver
genesymbol_syn
KIAA0201
resolver
hgnc
HGNC:16969
resolver
uniprot
A0A0A0MSM0
resolver
uniprot
B4DY72
resolver
uniprot
B4DYH1
resolver
uniprot
O95739
resolver
uniprot
Q5TBM6
resolver
uniprot
Q5TBM7
resolver
uniprot
Q5TBM8
resolver
uniprot
Q9UPC4
resolver
uniprot_entry
A0A0A0MSM0_HUMAN
resolver
uniprot_entry
B4DY72_HUMAN
resolver
uniprot_entry
HS105_HUMAN
resolver
uniprot_sec
B4DYH1
resolver
uniprot_sec
O95739
resolver
uniprot_sec
Q5TBM6
resolver
uniprot_sec
Q5TBM7
resolver
uniprot_sec
Q5TBM8
resolver
uniprot_sec
Q9UPC4
resolver
amino_acid_sequence
MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGIKVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFFGKDISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLIWNHDSEDTEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDKNVQQDNSEAGTQPQVQTDAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFICEQDHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERPKMFEELGQRLQHYAKIAADFRNKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTKIKELNNTCEPVVTQPKPKIESPKLERTPNGPNIDKKEEDLEDKNNFGAEPPHQNGECYPNEKNSVNMDLD
uniprot
proteins
function
FUNCTION: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250|UniProtKB:Q60446, ECO:0000250|UniProtKB:Q61699, ECO:0000269|PubMed:24318877}.
uniprot
proteins
mass_dalton
96865
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity. {ECO:0000250|UniProtKB:Q61699}.
uniprot
proteins
protein_family
Heat shock protein 70 family
uniprot
proteins
pubmed
10865058
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16232202
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24318877
uniprot
proteins
pubmed
9039502
uniprot
proteins
pubmed
9610721
uniprot
proteins
pubmed
9931472
uniprot
proteins
sequence_length
858
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9931472}.
uniprot
proteins