MAP2K3
entrez
5606
canonical
uniprot
P46734
canonical
ensembl
ENSG00000034152
resolver
ensp
ENSP00000319139
resolver
ensp
ENSP00000345083
resolver
ensp
ENSP00000355081
resolver
ensp
ENSP00000661670
resolver
ensp
ENSP00000707877
resolver
genesymbol
MAP2K3
resolver
genesymbol_syn
MEK3
resolver
genesymbol_syn
MKK3
resolver
genesymbol_syn
PRKMK3
resolver
genesymbol_syn
SKK2
resolver
hgnc
HGNC:6843
resolver
uniprot
B3KSK7
resolver
uniprot
Q6FI23
resolver
uniprot
Q99441
resolver
uniprot
Q9UE71
resolver
uniprot
Q9UE72
resolver
uniprot_entry
MP2K3_HUMAN
resolver
uniprot_entry
Q6FI23_HUMAN
resolver
uniprot_sec
B3KSK7
resolver
uniprot_sec
Q99441
resolver
uniprot_sec
Q9UE71
resolver
uniprot_sec
Q9UE72
resolver
activity_regulation
ACTIVITY REGULATION: Activated by dual phosphorylation on Ser-218 and Thr-222. {ECO:0000269|PubMed:8622669}.
uniprot
proteins
amino_acid_sequence
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in MAP2K3 may be involved in colon cancer.
uniprot
proteins
ec_number
2.7.12.2
uniprot
proteins
function
FUNCTION: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. {ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:8622669}.
uniprot
proteins
mass_dalton
39318
uniprot
proteins
mutagenesis
MUTAGEN 218; /note="S->A: Inactivation."; /evidence="ECO:0000269|PubMed:8622669"; MUTAGEN 218; /note="S->E: Constitutive activation."; /evidence="ECO:0000269|PubMed:8622669"; MUTAGEN 222; /note="T->A: Inactivation."; /evidence="ECO:0000269|PubMed:8622669"; MUTAGEN 222; /note="T->E: Constitutive activation."; /evidence="ECO:0000269|PubMed:8622669
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases positively regulates the kinase activity (PubMed:8622669). Phosphorylated by TAOK2 (PubMed:11279118). {ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:8622669}.; PTM: (Microbial infection) Yersinia YopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway. {ECO:0000269|PubMed:16728640}.
uniprot
proteins
protein_family
MAP kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
11279118
uniprot
proteins
pubmed
11414763
uniprot
proteins
pubmed
11980910
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16709866
uniprot
proteins
pubmed
16728640
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21224381
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
7839144
uniprot
proteins
pubmed
8622669
uniprot
proteins
pubmed
8900184
uniprot
proteins
sequence_length
347
uniprot
proteins