Ints11
entrez
71957
canonical
uniprot
Q9CWS4
canonical
ensembl
ENSMUSG00000029034
resolver
ensp
ENSMUSP00000030901
resolver
enst
ENSMUST00000030901
resolver
genesymbol
Ints11
resolver
genesymbol_syn
Cpsf3l
resolver
uniprot
Q3TJ34
resolver
uniprot
Q3U7B0
resolver
uniprot
Q91X99
resolver
uniprot
Q922F0
resolver
uniprot_entry
INT11_MOUSE
resolver
uniprot_sec
Q3TJ34
resolver
uniprot_sec
Q3U7B0
resolver
uniprot_sec
Q91X99
resolver
uniprot_sec
Q922F0
resolver
activity_regulation
ACTIVITY REGULATION: The RNA endonuclease activity is inhibited by BRAT1 that forms hydrogen bond and hydrophobic interactions with the active site. {ECO:0000250|UniProtKB:Q5TA45}.
uniprot
proteins
amino_acid_sequence
MPEIRVTPLGAGQDVGRSCILVSISGKNVMLDCGMHMGYNDDRRFPDFSYITQSGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFITWTNQKIRKTFVQRNMFEFKHIKAFDRTFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQMLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLRQKIEQEFRVSCYMPANGETVTLPTSPSIPVGISLGLLKREMVQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLQDTRKEQETALRVYSHLKSTLKDHCVQHLPDGSVTVESILIQAAAHSEDPGTKVLLVSWTYQDEELGSFLTTLLKNGLPQAPS
uniprot
proteins
ec_number
3.1.27.-
uniprot
proteins
function
FUNCTION: RNA endonuclease component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:36309014). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (By similarity). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (By similarity). Within the integrator complex, INTS11 constitutes the RNA endonuclease subunit that degrades exiting nascent RNA transcripts (PubMed:36309014). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (By similarity). {ECO:0000250|UniProtKB:Q5TA45, ECO:0000269|PubMed:36309014}.
uniprot
proteins
mass_dalton
67844
uniprot
proteins
post_translational_modification
PTM: Sumoylated; sumoylation regulates its subcellular location and is required for integrator complex integrity. {ECO:0000250|UniProtKB:Q5TA45}.
uniprot
proteins
protein_family
INTS11 subfamily
uniprot
proteins
protein_family
Metallo-beta-lactamase superfamily
uniprot
proteins
protein_family
RNA-metabolizing metallo-beta-lactamase-like family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36309014
uniprot
proteins
sequence_length
600
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5TA45}. Cytoplasm {ECO:0000250|UniProtKB:Q5TA45}.
uniprot
proteins