Crhr1
entrez
58959
canonical
uniprot
P35353
canonical
ensembl
ENSRNOG00000004900
resolver
ensembl
ENSRNOG00055028694
resolver
ensembl
ENSRNOG00060014769
resolver
ensembl
ENSRNOG00065031411
resolver
ensp
ENSRNOP00000006764
resolver
ensp
ENSRNOP00000103286
resolver
ensp
ENSRNOP00000109517
resolver
ensp
ENSRNOP00055040862
resolver
ensp
ENSRNOP00060020129
resolver
ensp
ENSRNOP00065044592
resolver
enst
ENSRNOT00000006764
resolver
enst
ENSRNOT00000147891
resolver
enst
ENSRNOT00000169053
resolver
enst
ENSRNOT00055049662
resolver
enst
ENSRNOT00060025266
resolver
enst
ENSRNOT00065054188
resolver
genesymbol
Crhr1
resolver
genesymbol_syn
Crhr
resolver
uniprot
A0ABK0L2T9
resolver
uniprot
A0ABK0LWV1
resolver
uniprot
B3SXS3
resolver
uniprot_entry
A0ABK0L2T9_RAT
resolver
uniprot_entry
A0ABK0LWV1_RAT
resolver
uniprot_entry
B3SXS3_RAT
resolver
uniprot_entry
CRHR1_RAT
resolver
amino_acid_sequence
MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for CRH and UCN stress hormones, which plays a central role in whole body adaptation to stress (PubMed:11567096, PubMed:8243338, PubMed:8274282). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and downstream effectors, such as adenylate cyclase (By similarity). CRHR1 is mainly coupled to G(s) G protein (GNAS), mediating activation of adenylate cyclase activity and production of cAMP (By similarity). In some conditions, can also couple to G(q) G protein (GNAQ) and mediate production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers (By similarity). CRHR1-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (By similarity). Mediates both anxiogenic and anxiolytic response to stress in glutamatergic and dopaminergic neurons, respectively (By similarity). CRHR1 also plays a critical role in addiction by mediating the brain's stress response, particularly during withdrawal and relapse: it drives the transition to compulsive drug seeking by increasing anxiety and negative emotional states (By similarity). {ECO:0000250|UniProtKB:P34998, ECO:0000250|UniProtKB:P35347, ECO:0000269|PubMed:11567096, ECO:0000269|PubMed:8243338, ECO:0000269|PubMed:8274282}.
uniprot
proteins
mass_dalton
47842
uniprot
proteins
post_translational_modification
PTM: C-terminal Ser or Thr residues may be phosphorylated. Phosphorylation at Ser-301 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling. {ECO:0000250|UniProtKB:P34998}.
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
11567096
uniprot
proteins
pubmed
23300088
uniprot
proteins
pubmed
8243338
uniprot
proteins
pubmed
8274282
uniprot
proteins
pubmed
8662941
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8243338, ECO:0000269|PubMed:8274282}; Multi-pass membrane protein {ECO:0000255}. Note=Agonist-binding promotes endocytosis. {ECO:0000250|UniProtKB:P34998}.
uniprot
proteins
transmembrane_region
TRANSMEM 114..139; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P34998"; TRANSMEM 153..176; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P34998"; TRANSMEM 186..215; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P34998"; TRANSMEM 228..249; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P34998"; TRANSMEM 268..292; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P34998"; TRANSMEM 312..329; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P34998"; TRANSMEM 339..365; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P34998
uniprot
proteins