Sla2
entrez
77799
canonical
uniprot
Q8R4L0
canonical
ensembl
ENSMUSG00000027636
resolver
ensp
ENSMUSP00000029164
resolver
ensp
ENSMUSP00000105189
resolver
ensp
ENSMUSP00000242644
resolver
ensp
ENSMUSP00000242645
resolver
genesymbol
Sla2
resolver
uniprot
Q3UU74
resolver
uniprot
Q8C0K2
resolver
uniprot
Q8VI42
resolver
uniprot
Q9D1Z9
resolver
uniprot_entry
SLAP2_MOUSE
resolver
uniprot_sec
Q3UU74
resolver
uniprot_sec
Q8C0K2
resolver
uniprot_sec
Q8VI42
resolver
uniprot_sec
Q9D1Z9
resolver
amino_acid_sequence
MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDDA
uniprot
proteins
function
FUNCTION: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269|PubMed:11891219, ECO:0000269|PubMed:12024036}.
uniprot
proteins
mass_dalton
28476
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Abolishes localization to membranes."; /evidence="ECO:0000269|PubMed:11891219, ECO:0000269|PubMed:12024036"; MUTAGEN 27; /note="M->V: Abolishes isoform 2."; /evidence="ECO:0000269|PubMed:12024036"; MUTAGEN 82; /note="P->L: Does not affect its inhibitory function."; /evidence="ECO:0000269|PubMed:11891219"; MUTAGEN 120; /note="R->E: Abolishes interaction with ZAP70, and its inhibitory function."; /evidence="ECO:0000269|PubMed:11891219, ECO:0000269|PubMed:12024036
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CSF1R. {ECO:0000269|PubMed:12024036, ECO:0000269|PubMed:17353186}.
uniprot
proteins
pubmed
11891219
uniprot
proteins
pubmed
12024036
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17353186
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Cytoplasmic vesicle. Late endosome. Note=Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.
uniprot
proteins