Hadh
entrez
113965
canonical
uniprot
Q9WVK7
canonical
ensembl
ENSRNOG00000010697
resolver
ensembl
ENSRNOG00055010800
resolver
ensembl
ENSRNOG00060022720
resolver
ensembl
ENSRNOG00065014559
resolver
ensp
ENSRNOP00000014658
resolver
ensp
ENSRNOP00055014662
resolver
ensp
ENSRNOP00060032592
resolver
ensp
ENSRNOP00065018745
resolver
enst
ENSRNOT00000014658
resolver
enst
ENSRNOT00055018253
resolver
enst
ENSRNOT00060039400
resolver
enst
ENSRNOT00065024043
resolver
genesymbol
Hadh
resolver
genesymbol_syn
Had
resolver
genesymbol_syn
Hadhsc
resolver
genesymbol_syn
Schad
resolver
uniprot_entry
HCDH_RAT
resolver
amino_acid_sequence
MAFVTRQFVRSMSSSSSASAAAKKILIKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLKRMAKKKFTENPKAADEFVEKTLSSLSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANATTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIVNRLLVPYLIEAIRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMDPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKYK
uniprot
proteins
ec_number
1.1.1.35
uniprot
proteins
function
FUNCTION: Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (By similarity). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity). {ECO:0000250|UniProtKB:Q16836, ECO:0000250|UniProtKB:Q61425}.
uniprot
proteins
mass_dalton
34448
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
uniprot
proteins
post_translational_modification
PTM: Succinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5. {ECO:0000250|UniProtKB:Q61425}.
uniprot
proteins
protein_family
3-hydroxyacyl-CoA dehydrogenase family
uniprot
proteins
pubmed
10064895
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P00348}.
uniprot
proteins