CCL22
entrez
6367
canonical
uniprot
O00626
canonical
ensembl
ENSG00000102962
resolver
ensp
ENSP00000219235
resolver
ensp
ENSP00000611254
resolver
enst
ENST00000219235
resolver
enst
ENST00000941195
resolver
genesymbol
CCL22
resolver
genesymbol_syn
MDC
resolver
genesymbol_syn
SCYA22
resolver
hgnc
HGNC:10621
resolver
uniprot
A0N0Q6
resolver
uniprot
B2R4W2
resolver
uniprot_entry
CCL22_HUMAN
resolver
uniprot_sec
A0N0Q6
resolver
uniprot_sec
B2R4W2
resolver
amino_acid_sequence
MDRLQTALLVVLVLLAVALQATEAGPYGANMEDSVCCRDYVRYRLPLRVVKHFYWTSDSCPRPGVVLLTFRDKEICADPRVPWVKMILNKLSQ
uniprot
proteins
function
FUNCTION: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.
uniprot
proteins
mass_dalton
10625
uniprot
proteins
post_translational_modification
PTM: The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes. {ECO:0000269|PubMed:11241286}.
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
11241286
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
9151897
uniprot
proteins
pubmed
9312138
uniprot
proteins
pubmed
9430724
uniprot
proteins
sequence_length
93
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins