Svep1
entrez
64817
canonical
uniprot
A2AVA0
canonical
ensembl
ENSMUSG00000028369
resolver
ensp
ENSMUSP00000045856
resolver
genesymbol
Svep1
resolver
uniprot
Q8C720
resolver
uniprot
Q8CBT2
resolver
uniprot
Q922H0
resolver
uniprot
Q9CUT3
resolver
uniprot
Q9ES77
resolver
uniprot_entry
SVEP1_MOUSE
resolver
uniprot_sec
Q8C720
resolver
uniprot_sec
Q8CBT2
resolver
uniprot_sec
Q922H0
resolver
uniprot_sec
Q9CUT3
resolver
uniprot_sec
Q9ES77
resolver
amino_acid_sequence
MWSRLAFCCWALALVSGWTNFQPVAPSLNFSFRLFPEASPGALGRLAVPPASSEEEAAGSKVERLGRAFRSRVRRLRELSGSLELVFLVDESSSVGQTNFLNELKFVRKLLSDFPVVSTATRVAIVTFSSKNNVVARVDYISTSRAHQHKCALLSREIPAITYRGGGTYTKGAFQQAAQILRHSRENSTKVIFLITDGYSNGGDPRPIAASLRDFGVEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALARRALHEDLPSGSFIQEDMARCSYLCEAGKDCCDRMASCKCGTHTGQFECICEKGYYGKGLQHECTACPSGTYKPEASPGGISTCIPCPDVSHTSPPGSTSPEDCVCREGYQRSGQTCEVVHCPALKPPENGFFIQNTCKNHFNAACGVRCRPGFDLVGSSIHLCQPNGLWSGTESFCRVRTCPHLRQPKHGHISCSTAEMSYNTLCLVTCNEGYRLEGSTRLTCQGNAQWDGPEPRCVERHCATFQKPKGVIISPPSCGKQPARPGMTCQLSCRQGYILSGVREVRCATSGKWSAKVQTAVCKDVEAPQISCPNDIEAKTGEQQDSANVTWQVPTAKDNSGEKVSVHVHPAFTPPYLFPIGDVAITYTATDSSGNQASCTFYIKVIDVEPPVIDWCRSPPPIQVVEKEHPASWDEPQFSDNSGAELVITSSHTQGDMFPHGETVVWYTATDPSGNNRTCDIHIVIKGSPCEVPFTPVNGDFICAQDSAGVNCSLSCKEGYDFTEGSTEKYYCAFEDGIWRPPYSTEWPDCAIKRFANHGFKSFEMLYKTTRCDDMDLFKKFSAAFETTLGNMVPSFCNDADDIDCRLEDLTKKYCIEYNYNYENGFAIGPGGWGAGNRLDYSYDHFLDVVQETPTDVGKARSSRIKRTVPLSDPKIQLIFNITASVPLPEERNDTLELENQQRLIKTLETITNRLKSTLNKEPMYSFQLASETVVADSNSLETEKAFLFCRPGSVLRGRMCVNCPLGTSYSLEHSTCESCLMGSYQDEEGQLECKLCPPRTHTEYLHSRSVSECKAQCKQGTYSSSGLETCESCPLGTYQPEFGSRSCLLCPETTTTVKRGAVDISACGVPCPVGEFSRSGLTPCYPCPRDYYQPNAGKSFCLACPFYGTTTITGATSITDCSSFSSTFSAAEESIVPLVAPGHSQNKYEVSSQVFHECFLNPCHNSGTCQQLGRGYVCLCPPGYTGLKCETDIDECSSLPCLNGGICRDQVGGFTCECSLGYSGQICEENINECISSPCLNKGTCTDGLASYRCTCVKGYMGVHCETDVNECQSSPCLNNAVCKDQVGGFSCKCPPGFLGTRCEKNVDECLSQPCQNGATCKDGANSFRCQCPAGFTGTHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGHRCETEQPSGFNLDFEVSGIYGYVLLDGVLPTLHAITCAFWMKSSDVINYGTPISYALEDDKDNTFLLTDYNGWVLYVNGKEKITNCPSVNDGIWHHIAITWTSTGGAWRVYIDGELSDGGTGLSIGKAIPGGGALVLGQEQDKKGEGFNPAESFVGSISQLNLWDYVLSPQQVKLLASSCPEELSRGNVLAWPDFLSGITGKVKVDSSSMFCSDCPSLEGSVPHLRPASGNRKPGSKVSLFCDPGFQMVGNPVQYCLNQGQWTQPLPHCERIRCGLPPALENGFYSAEDFHAGSTVTYQCTSGYYLLGDSRMFCTDNGSWNGISPSCLDVDECAVGSDCSEHASCLNTNGSYVCSCNPPYTGDGKNCAEPVKCKAPENPENGHSSGEIYTVGTAVTFSCDEGHELVGVSTITCLETGEWDRLRPSCEAISCGVPPVPENGGVDGSAFTYGSKVVYRCDKGYTLSGDEESACLASGSWSHSSPVCELVKCSQPEDINNGKYILSGLTYLSIASYSCENGYSLQGPSLLECTASGSWDRAPPSCQLVSCGEPPIVKDAVITGSNFTFGNTVAYTCKEGYTLAGPDTIVCQANGKWNSSNHQCLAVSCDEPPNVDHASPETAHRLFGDTAFYYCADGYSLADNSQLICNAQGNWVPPAGQAVPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECLRGGEWSPSPLSVQCIPVRCGEPPSIANGYPSGTNYSFGAVVAYSCHKGFYIKGEKKSTCEATGQWSKPTPTCHPVSCNEPPKVENGFLEHTTGRTFESEARFQCNPGYKAAGSPVFVCQANRHWHSDAPLSCTPLNCGKPPPIQNGFLKGESFEVGSKVQFVCNEGYELVGDNSWTCQKSGKWSKKPSPKCVPTKCAEPPLLENQLVLKELASEVGVMTISCKEGHALQGPSVLKCLPSGQWNGSFPICKMVLCPSPPLIPFGVPASSGALHFGSTVKYLCVDGFFLRGSPTILCQADSTWSSPLPECVPVECPQPEEILNGIIHVQGLAYLSTTLYTCKPGFELVGNATTLCGENGQWLGGKPMCKPIECPEPKEILNGQFSSVSFQYGQTITYFCDRGFRLEGPKSLTCLETGDWDMDPPSCDAIHCSDPQPIENGFVEGADYRYGAMIIYSCFPGFQVLGHAMQTCEESGWSSSSPTCVPIDCGLPPHIDFGDCTKVRDGQGHFDQEDDMMEVPYLAHPQHLEATAKALENTKESPASHASHFLYGTMVSYSCEPGYELLGIPVLICQEDGTWNGTAPSCISIECDLPVAPENGFLHFTQTTMGSAAQYSCKPGHILEGSHLRLCLQNKQWSGTVPRCEAISCSKPNPLWNGSIKGDDYSYLGVLYYECDSGYILNGSKKRTCQENRDWDGHEPMCIPVDCGSPPVPTNGRVKGEEYTFQKEITYSCREGFILEGARSRICLTNGSWSGATPSCMPVRCPAPPQVPNGVADGLDYGFKKEVAFHCLEGYVLQGAPRLTCQSNGTWDAEVPVCKPATCGPPADLPQGFPNGFSFYHGGHIQYQCFTGYKLHGNPSRRCLPNGSWSGSSPSCLPCRCSTPIIQQGTINATDLGCGKTVQIECFKGFKLLGLSEITCDANGQWSDVPLCEHAQCGPLPTIPNAIVLEGSLSEDNVVTYSCRPGYTMQGSSDLICTEKAIWSQPYPTCEPLSCGPPPTVANAVATGEAHTYESKVKLRCLEGYVMDSDTDTFTCQQDGHWVPERITCSPKKCPVPSNMTRIRFHGDDFQVNRQVSVSCAEGFTHEGVNWSTCQPDGTWEPPFSDESCIPVVCGHPESPAHGSVVGNKHSFGSTIVYQCDPGYKLEGNRERICQENRQWSGEVAVCRENRCETPAEFPNGKAVLENTTSGPSLLFSCHRGYTLEGSPEAHCTANGTWNHLTPLCKPNPCPVPFVIPENAVLSEKEFYVDQNVSIKCREGFLLKGNGVITCSPDETWTHTNARCEKISCGPPSHVENAIARGVYYQYGDMITYSCYSGYMLEGSLRSVCLENGTWTPSPVCRAVCRFPCQNGGVCQRPNACSCPDGWMGRLCEEPICILPCLNGGRCVAPYQCDCPTGWTGSRCHTATCQSPCLNGGKCIRPNRCHCLSAWTGHDCSRKRRAGL
uniprot
proteins
function
FUNCTION: Required for morphological development, cell alignment and migration of lymphatic endothelial cells during embryonic development, potentially via modulation of ANGPT2-TIE1 signaling and subsequent activation of FOXC2 transcription (PubMed:28179430). Required for embryonic lymphatic vascular development, via mediating the correct formation of the first lymphovenous contact site and tight association of the lymphatic endothelium with the venous endothelium (PubMed:28179432). Represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells, via its interaction with integrins, thereby inhibiting vasocontraction (PubMed:35802072). Promotes platelet activation, via its interaction with PEAR1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). Plays a role in epidermal development and keratinocyte differentiation, independent of cell-cell adhesion (PubMed:27892606). May play a role in initial cell attachment of stromal osteogenic cells (PubMed:16206243). May promote myoblast cell adhesion when in the presence of integrin ITGA9:ITGB1 (PubMed:22654117). {ECO:0000269|PubMed:16206243, ECO:0000269|PubMed:22654117, ECO:0000269|PubMed:27892606, ECO:0000269|PubMed:28179430, ECO:0000269|PubMed:28179432, ECO:0000269|PubMed:35802072, ECO:0000269|PubMed:36792666}.
uniprot
proteins
mass_dalton
387457
uniprot
proteins
mutagenesis
MUTAGEN 2634; /note="D->A: No effect on the interaction with integrin ITGA9:ITGB1."; /evidence="ECO:0000269|PubMed:22654117"; MUTAGEN 2635; /note="Q->A: No effect on the interaction with integrin ITGA9:ITGB1."; /evidence="ECO:0000269|PubMed:22654117"; MUTAGEN 2636; /note="E->A: No effect on the interaction with integrin ITGA9:ITGB1."; /evidence="ECO:0000269|PubMed:22654117"; MUTAGEN 2637; /note="D->A: Reduces interaction with integrin ITGA9:ITGB1."; /evidence="ECO:0000269|PubMed:22654117"; MUTAGEN 2638; /note="D->A: Reduces interaction with integrin ITGA9:ITGB1."; /evidence="ECO:0000269|PubMed:22654117"; MUTAGEN 2639; /note="M->A: No effect on the interaction with integrin ITGA9:ITGB1."; /evidence="ECO:0000269|PubMed:22654117"; MUTAGEN 2640; /note="M->A: Reduces interaction with integrin ITGA9:ITGB1."; /evidence="ECO:0000269|PubMed:22654117"; MUTAGEN 2641; /note="E->A: Abolishes interaction with integrin ITGA9:ITGB1."; /evidence="ECO:0000269|PubMed:22654117"; MUTAGEN 2642; /note="V->A: No effect on the interaction with integrin ITGA9:ITGB1."; /evidence="ECO:0000269|PubMed:22654117"; MUTAGEN 2643; /note="P->A: No effect on the interaction with integrin ITGA9:ITGB1."; /evidence="ECO:0000269|PubMed:22654117"; MUTAGEN 2644; /note="Y->A: No effect on the interaction with integrin ITGA9:ITGB1."; /evidence="ECO:0000269|PubMed:22654117"; MUTAGEN 2645; /note="L->A: No effect on the interaction with integrin ITGA9:ITGB1."; /evidence="ECO:0000269|PubMed:22654117
uniprot
proteins
pubmed
11062057
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16206243
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22654117
uniprot
proteins
pubmed
27892606
uniprot
proteins
pubmed
28179430
uniprot
proteins
pubmed
28179432
uniprot
proteins
pubmed
35802072
uniprot
proteins
pubmed
36792666
uniprot
proteins
sequence_length
3567
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22654117}. Nucleus {ECO:0000250|UniProtKB:Q4LDE5}. Cytoplasm {ECO:0000250|UniProtKB:Q4LDE5}. Membrane {ECO:0000250|UniProtKB:Q4LDE5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q4LDE5}.
uniprot
proteins