Ska3
entrez
361047
canonical
uniprot
B2GUZ2
canonical
ensembl
ENSRNOG00000021847
resolver
ensembl
ENSRNOG00055012491
resolver
ensembl
ENSRNOG00060021400
resolver
ensembl
ENSRNOG00065029392
resolver
ensp
ENSRNOP00000033626
resolver
ensp
ENSRNOP00000077309
resolver
ensp
ENSRNOP00055017246
resolver
ensp
ENSRNOP00060030617
resolver
ensp
ENSRNOP00065041727
resolver
enst
ENSRNOT00000032723
resolver
enst
ENSRNOT00055021313
resolver
enst
ENSRNOT00060037117
resolver
enst
ENSRNOT00065050765
resolver
genesymbol
Ska3
resolver
genesymbol_syn
Rama1
resolver
uniprot
A0A8L2QHE9
resolver
uniprot
A6KHD2
resolver
uniprot_entry
A0A8L2QHE9_RAT
resolver
uniprot_entry
SKA3_RAT
resolver
uniprot_sec
A6KHD2
resolver
amino_acid_sequence
MNPIQSFHCKLRSLATVLDGETARLLRALDGEDSDFEDSSARILCDLYSEVQTLKDDVNAHLDKARLESRESTHFIKAAKVLMKKNSADIIKLREFFQKYGYQARDKEDSACEHRVSNSSPGLAVCKDTQEPGVKQELSEPRVPRGSAPEEPLRSPQLSDFGLQRYMVSQGPANPRQETVSLKEDRASETTPAKDPSVQVLKTPRCALKMDDFECVTPKLEHFGISEYTMCLNEDYTMGLKNMKSIKSSPLSGVGGEAVETGPVTSDNSFAIPGPMIQQLEKNDVEYINSPLPPKFCTPGLKIPSSMDSTDLVSIDYPLSKPNSSPTDLEDKDCAPLILNSDECYQSFADPHSPTITSYENFTTPSPPKVTAIPEDILQMLKYNSNLASPIDVKAMPLRRGFTSKGQSTRGAANKENW
uniprot
proteins
function
FUNCTION: Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces. The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules. The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase. Within the complex, binds microtubules but with a much lower affinity than SKA1. Promotes stability of the polo-like kinase PLK1 protein (By similarity). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (By similarity). {ECO:0000250|UniProtKB:Q8C263, ECO:0000250|UniProtKB:Q8IX90}.
uniprot
proteins
mass_dalton
46223
uniprot
proteins
protein_family
SKA3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8IX90}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q8IX90}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8IX90}. Note=Localizes to bioriented kinetochores and spindle microtubules during prometaphase and metaphase in a NDC80 complex-dependent manner. The SKA complex begins to concentrate at kinetochores before microtubule attachment but reaches maximum levels on bioriented metaphase chromosomes. The localization of the SKA complex to kinetochores is positively regulated by protein serine/threonine kinase CDK1. The localization of the SKA complex to kinetochores is negatively regulated by protein serine/threonine kinase AURKB, and this action is opposed directly or indirectly by the PP1 and PP2A protein phosphatase complexes. Localizes at the centrosome during interphase and prophase. {ECO:0000250|UniProtKB:Q8IX90}.
uniprot
proteins