TCHP
entrez
84260
canonical
uniprot
Q9BT92
canonical
ensembl
ENSG00000139437
resolver
ensp
ENSP00000324404
resolver
ensp
ENSP00000384520
resolver
ensp
ENSP00000440838
resolver
ensp
ENSP00000652060
resolver
enst
ENST00000312777
resolver
enst
ENST00000405876
resolver
enst
ENST00000544838
resolver
genesymbol
TCHP
resolver
hgnc
HGNC:28135
resolver
uniprot
Q8NAG0
resolver
uniprot_entry
TCHP_HUMAN
resolver
uniprot_sec
Q8NAG0
resolver
amino_acid_sequence
MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPKPYGHPKIAWN
uniprot
proteins
function
FUNCTION: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis (PubMed:25270598). {ECO:0000269|PubMed:15731013, ECO:0000269|PubMed:18931701, ECO:0000269|PubMed:25270598}.
uniprot
proteins
mass_dalton
61072
uniprot
proteins
mutagenesis
MUTAGEN 50; /note="K->R: Decreased ubiquitination. Negative effect on ubiquitination is higher when associated with R-57."; /evidence="ECO:0000269|PubMed:25270598"; MUTAGEN 57; /note="K->R: Decreased ubiquitination. Negative effect on ubiquitination is higher when associated with R-50."; /evidence="ECO:0000269|PubMed:25270598
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination by the BCR(KCTD17) E3 ubiquitin ligase complex results in proteasomal degradation, and induces ciliogenesis. {ECO:0000269|PubMed:25270598}.
uniprot
proteins
protein_family
TCHP family
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15731013
uniprot
proteins
pubmed
18931701
uniprot
proteins
pubmed
25270598
uniprot
proteins
pubmed
38538594
uniprot
proteins
sequence_length
498
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15731013}. Cytoplasm {ECO:0000269|PubMed:18931701}. Cell membrane {ECO:0000305|PubMed:15731013, ECO:0000305|PubMed:18931701}. Mitochondrion {ECO:0000269|PubMed:18931701}. Cell junction, desmosome {ECO:0000269|PubMed:15731013}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:38538594}.
uniprot
proteins