RNF10
entrez
9921
canonical
uniprot
Q8N5U6
canonical
ensembl
ENSG00000022840
resolver
ensp
ENSP00000322242
resolver
ensp
ENSP00000415682
resolver
genesymbol
RNF10
resolver
genesymbol_syn
KIAA0262
resolver
genesymbol_syn
RIE2
resolver
hgnc
HGNC:10055
resolver
uniprot
A0A024RBP0
resolver
uniprot
Q92550
resolver
uniprot
Q9NPP8
resolver
uniprot
Q9ULW4
resolver
uniprot_entry
A0A024RBP0_HUMAN
resolver
uniprot_entry
RNF10_HUMAN
resolver
uniprot_sec
Q92550
resolver
uniprot_sec
Q9NPP8
resolver
uniprot_sec
Q9ULW4
resolver
amino_acid_sequence
MPLSSPNAAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSSGSKRYNRKRELSYPKNESFNNQSRRSSSQKSKTFNKMPPQRGGGSSKLFSSSFNGGRRDEVAEAQRAEFSPAQFSGPKKINLNHLLNFTFEPRGQTGHFEGSGHGSWGKRNKWGHKPFNKELFLQANCQFVVSEDQDYTAHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYSSVHKKDLKSVVATESHQYVVGDTITMQLMKREKGVLVALPKSKWMNVDHPIHLGDEQHSQYSKLLLASKEQVLHRVVLEEKVALEQQLAEEKHTPESCFIEAAIQELKTREEALSGLAGSRREVTGVVAALEQLVLMAPLAKESVFQPRKGVLEYLSAFDEETTEVCSLDTPSRPLALPLVEEEEAVSEPEPEGLPEACDDLELADDNLKEGTICTESSQQEPITKSGFTRLSSSPCYYFYQAEDGQHMFLHPVNVRCLVREYGSLERSPEKISATVVEIAGYSMSEDVRQRHRYLSHLPLTCEFSICELALQPPVVSKETLEMFSDDIEKRKRQRQKKAREERRRERRIEIEENKKQGKYPEVHIPLENLQQFPAFNSYTCSSDSALGPTSTEGHGALSISPLSRSPGSHADFLLTPLSPTASQGSPSFCVGSLEEDSPFPSFAQMLRVGKAKADVWPKTAPKKDENSLVPPAPVDSDGESDNSDRVPVPSFQNSFSQAIEAAFMKLDTPATSDPLSEEKGGKKRKKQKQKLLFSTSVVHTK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (PubMed:34348161, PubMed:34469731, PubMed:39609413, PubMed:39947182, PubMed:39947183, PubMed:40022732). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC) or elongation (PubMed:34348161, PubMed:34469731, PubMed:39609413, PubMed:39947182, PubMed:39947183, PubMed:40022732). The ribosome quality control is activated in response to ribosome subunit imbalance, amino acid starvation or downstream the EIF2AK4/GCN2-mediated integrated stress response (ISR) (PubMed:39609413, PubMed:39947182, PubMed:39947183, PubMed:40022732). RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3: monoubiquitinated RPS2/us5 and RPS3/us3 are then recognized by RIOK3 kinase, leading to 18S non-functional rRNA decay and degradation of the 40S ribosomal subunit (PubMed:34348161, PubMed:34469731, PubMed:39609413, PubMed:39947182, PubMed:39947183, PubMed:40022732). The action of RNF10 in iRQC is counteracted by USP10 (PubMed:34469731). {ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:39609413, ECO:0000269|PubMed:39947182, ECO:0000269|PubMed:39947183, ECO:0000269|PubMed:40022732}.
uniprot
proteins
mass_dalton
89927
uniprot
proteins
mutagenesis
MUTAGEN 225..228; /note="CPIC->SPIS: Abolished E3 ubiquitin-protein ligase activity and ability to monoubiquitinate RPS2/us5 and RPS3/us3."; /evidence="ECO:0000269|PubMed:34348161"; MUTAGEN 225; /note="C->S: Abolished E3 ubiquitin-protein ligase activity and ability to monoubiquitinate RPS2/us5 and RPS3/us3."; /evidence="ECO:0000269|PubMed:34348161"; MUTAGEN 228; /note="C->S: Abolished E3 ubiquitin-protein ligase activity and ability to monoubiquitinate RPS2/us5 and RPS3/us3."; /evidence="ECO:0000269|PubMed:34348161
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:39609413, ECO:0000269|PubMed:39947182, ECO:0000269|PubMed:39947183, ECO:0000269|PubMed:40022732}.
uniprot
proteins
protein_family
RNF10 family
uniprot
proteins
pubmed
10697961
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335786
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
34348161
uniprot
proteins
pubmed
34469731
uniprot
proteins
pubmed
39609413
uniprot
proteins
pubmed
39947182
uniprot
proteins
pubmed
39947183
uniprot
proteins
pubmed
40022732
uniprot
proteins
pubmed
9039502
uniprot
proteins
sequence_length
811
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16335786}. Nucleus {ECO:0000250|UniProtKB:Q5XI59}.
uniprot
proteins