Igfbp2
entrez
25662
canonical
uniprot
P12843
canonical
ensembl
ENSRNOG00000016957
resolver
ensembl
ENSRNOG00065008583
resolver
ensp
ENSRNOP00000023068
resolver
ensp
ENSRNOP00065010133
resolver
enst
ENSRNOT00000023068
resolver
enst
ENSRNOT00065013641
resolver
genesymbol
Igfbp2
resolver
genesymbol_syn
Igfbp-2
resolver
uniprot
Q569C7
resolver
uniprot_entry
IBP2_RAT
resolver
uniprot_sec
Q569C7
resolver
amino_acid_sequence
MLPRLGGPALPLLLPSLLLLLLLGAGGCGPGVRAEVLFRCPPCTPERLAACGPPPDAPCAELVREPGCGCCSVCARQEGEACGVYIPRCAQTLRCYPNPGSELPLKALVTGAGTCEKRRVGATPQQVADSEDDHSEGGLVENHVDGTMNMLGGSSAGRKPPKSGMKELAVFREKVNEQHRQMGKGAKHLSLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDDRGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKPIQGAPTIRGDPECHLFYNEQQENDGAHAQRVQ
uniprot
proteins
function
FUNCTION: Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation. Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif. Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells. Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury. {ECO:0000250|UniProtKB:P18065}.
uniprot
proteins
mass_dalton
32855
uniprot
proteins
post_translational_modification
PTM: Cleaved by MMP9 leading to release of free IGF2 from IGFBP2-IGF2 complex, which contributes to enhance the motility and the growth of astrocytes. {ECO:0000250|UniProtKB:P18065}.; PTM: O-glycosylated. {ECO:0000250|UniProtKB:P18065}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2426267
uniprot
proteins
pubmed
2477691
uniprot
proteins
pubmed
2480123
uniprot
proteins
pubmed
2538475
uniprot
proteins
pubmed
2974285
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2426267, ECO:0000269|PubMed:2480123, ECO:0000269|PubMed:2538475}.
uniprot
proteins