Tnfsf11
entrez
21943
canonical
uniprot
O35235
canonical
ensembl
ENSMUSG00000022015
resolver
ensp
ENSMUSP00000022592
resolver
genesymbol
Tnfsf11
resolver
genesymbol_syn
Opgl
resolver
genesymbol_syn
Rankl
resolver
genesymbol_syn
Trance
resolver
uniprot
O35306
resolver
uniprot
Q3TWY5
resolver
uniprot
Q9JJK8
resolver
uniprot
Q9JJK9
resolver
uniprot
Q9R1Y0
resolver
uniprot_entry
TNF11_MOUSE
resolver
uniprot_sec
O35306
resolver
uniprot_sec
Q3TWY5
resolver
uniprot_sec
Q9JJK8
resolver
uniprot_sec
Q9JJK9
resolver
uniprot_sec
Q9R1Y0
resolver
amino_acid_sequence
MRRASRDYGKYLRSSEEMGSGPGVPHEGPLHPAPSAPAPAPPPAASRSMFLALLGLGLGQVVCSIALFLYFRAQMDPNRISEDSTHCFYRILRLHENADLQDSTLESEDTLPDSCRRMKQAFQGAVQKELQHIVGPQRFSGAPAMMEGSWLDVAQRGKPEAQPFAHLTINAASIPSGSHKVTLSSWYHDRGWAKISNMTLSNGKLRVNQDGFYYLYANICFRHHETSGSVPTDYLQLMVYVVKTSIKIPSSHNLMKGGSTKNWSGNSEFHFYSINVGGFFKLRAGEEISIQVSNPSLLDPDQDATYFGAFKVQDID
uniprot
proteins
disease_involvement
DISEASE: Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.
uniprot
proteins
function
FUNCTION: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor (PubMed:22437732). Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (By similarity). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts (PubMed:18586671, PubMed:24039232, PubMed:27336669). During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (PubMed:23395171, PubMed:26644563). {ECO:0000250|UniProtKB:O14788, ECO:0000269|PubMed:18586671, ECO:0000269|PubMed:22437732, ECO:0000269|PubMed:23395171, ECO:0000269|PubMed:24039232, ECO:0000269|PubMed:26644563, ECO:0000269|PubMed:27336669}.
uniprot
proteins
mass_dalton
35003
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10224132}.; PTM: The soluble form of isoform 1 derives from the membrane form by proteolytic processing. The cleavage may be catalyzed by ADAM17. A further shorter soluble form was observed. {ECO:0000269|PubMed:10224132}.
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
10196481
uniprot
proteins
pubmed
10224132
uniprot
proteins
pubmed
11250921
uniprot
proteins
pubmed
11581298
uniprot
proteins
pubmed
11733492
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18586671
uniprot
proteins
pubmed
20483727
uniprot
proteins
pubmed
21514407
uniprot
proteins
pubmed
22437732
uniprot
proteins
pubmed
23039992
uniprot
proteins
pubmed
23395171
uniprot
proteins
pubmed
24039232
uniprot
proteins
pubmed
26644563
uniprot
proteins
pubmed
27336669
uniprot
proteins
pubmed
9312132
uniprot
proteins
pubmed
9367155
uniprot
proteins
pubmed
9520411
uniprot
proteins
pubmed
9568710
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins