SUCLG2
entrez
8801
canonical
uniprot
Q96I99
canonical
ensembl
ENSG00000172340
resolver
ensp
ENSP00000307432
resolver
ensp
ENSP00000419325
resolver
ensp
ENSP00000710346
resolver
genesymbol
SUCLG2
resolver
hgnc
HGNC:11450
resolver
uniprot
C9JVT2
resolver
uniprot
O95195
resolver
uniprot
Q6NUH7
resolver
uniprot
Q86VX8
resolver
uniprot
Q8WUQ1
resolver
uniprot_entry
SUCB2_HUMAN
resolver
uniprot_sec
C9JVT2
resolver
uniprot_sec
O95195
resolver
uniprot_sec
Q6NUH7
resolver
uniprot_sec
Q86VX8
resolver
uniprot_sec
Q8WUQ1
resolver
amino_acid_sequence
MASPVAAQAGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQEYQSKKLMSDNGVRVQRFFVADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVQEAQKILNNSGLPITSAIDLEDAAKKAVASVAKK
uniprot
proteins
ec_number
6.2.1.-
uniprot
proteins
ec_number
6.2.1.4
uniprot
proteins
function
FUNCTION: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:40108300). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity). Also able to act as a GTP-specific itaconyl- and malyl-CoA synthetase (PubMed:40108300). {ECO:0000255|HAMAP-Rule:MF_03221, ECO:0000269|PubMed:40108300}.
uniprot
proteins
mass_dalton
46511
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_03221}.
uniprot
proteins
protein_family
GTP-specific subunit beta subfamily
uniprot
proteins
protein_family
Succinate/malate CoA ligase beta subunit family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
40108300
uniprot
proteins
pubmed
9765291
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03221}.
uniprot
proteins