Hells
entrez
15201
canonical
uniprot
Q60848
canonical
ensembl
ENSMUSG00000025001
resolver
ensp
ENSMUSP00000025965
resolver
genesymbol
Hells
resolver
genesymbol_syn
Lsh
resolver
genesymbol_syn
Pasg
resolver
uniprot
Q497T3
resolver
uniprot
Q8VDZ1
resolver
uniprot
Q9CYV7
resolver
uniprot_entry
HELLS_MOUSE
resolver
uniprot_sec
Q497T3
resolver
uniprot_sec
Q8VDZ1
resolver
uniprot_sec
Q9CYV7
resolver
amino_acid_sequence
MAEQTEPAVITPAMLEEEEQLEAAGLEKERKMLEEAQKSWDRESTEIRYRRLQHLLEKSNIYSKFLLTKMEQQQLEEQKKKEKLEKKKRSLKLTEGKSLVDGNGEKPVMKKKRGREDESYNISEVMSKEEILSVAKKHKDNEDESSSTTSLCVEDIQKNKDSNSMIKDRLSQTVRQNSKFFFDPVRKCNGQPVPFQQPKHFTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATIALMIQRGVPGPFLVCGPLSTLPNWMAEFKRFTPEIPTLLYHGTREDRRKLVKNIHKRQGTLQIHPVVVTSFEIAMRDQNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQILTPFLLRRLKSDVALEVPPKREVVVYAPLCNKQEIFYTAIVNRTIANMFGSCEKETVELSPTGRPKRRSRKSINYSELDQFPSELEKLISQIQPEVNRERTVVEGNIPIESEVNLKLRNIMMLLRKCCNHPYMIEYPIDPVTQEFKIDEELVTNSGKFLILDRMLPELKKRGHKVLVFSQMTSMLDILMDYCHLRNFIFSRLDGSMSYSEREKNIYSFNTDPDVFLFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQSGLSQSKNFLDAKELMELLKSRDYEREVKGSREKVISDEDLELLLDRSDLIDQMKASRPIKGKTGIFKILENSEDSSAECLF
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: ATP-dependent chromatin remodeler that regulates chromatin accessibility, DNA methylation, and histone modifications (PubMed:11711429, PubMed:14517253). It facilitates de novo DNA methylation at repetitive sequences and promotes transcriptional silencing via recruitment of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), contributing to heterochromatin formation and repression of transposable elements (PubMed:14517253, PubMed:14612388, PubMed:15647320, PubMed:37709749). Also involved in DNA repair by recruiting DNA damage response mediators to double-strand breaks in heterochromatin, promoting homologous recombination via RBBP8/CtIP-dependent end resection (PubMed:22946062). During meiosis, it is recruited by PRDM9 to recombination hotspots, aiding chromatin opening (PubMed:32001511). Through these diverse roles, is crucial for processes such as development, differentiation, and genomic stability (PubMed:11325543, PubMed:11357197, PubMed:15105378). Involved in regulation of the expansion or survival of lymphoid cells (PubMed:10781083, PubMed:37709749, PubMed:8647447). {ECO:0000269|PubMed:10781083, ECO:0000269|PubMed:11325543, ECO:0000269|PubMed:11357197, ECO:0000269|PubMed:11711429, ECO:0000269|PubMed:14517253, ECO:0000269|PubMed:14612388, ECO:0000269|PubMed:15105378, ECO:0000269|PubMed:15647320, ECO:0000269|PubMed:22946062, ECO:0000269|PubMed:32001511, ECO:0000269|PubMed:37709749, ECO:0000269|PubMed:8647447}.
uniprot
proteins
mass_dalton
95126
uniprot
proteins
mutagenesis
MUTAGEN 237; /note="K->Q: Loss of ATPase activity. Impaired repair of DNA damage."; /evidence="ECO:0000269|PubMed:22946062
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
10781083
uniprot
proteins
pubmed
11325543
uniprot
proteins
pubmed
11357197
uniprot
proteins
pubmed
11711429
uniprot
proteins
pubmed
14517253
uniprot
proteins
pubmed
14612388
uniprot
proteins
pubmed
15105378
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15647320
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22946062
uniprot
proteins
pubmed
32001511
uniprot
proteins
pubmed
37709749
uniprot
proteins
pubmed
8647447
uniprot
proteins
pubmed
9878251
uniprot
proteins
sequence_length
821
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10781083, ECO:0000269|PubMed:14517253, ECO:0000269|PubMed:14612388}. Chromosome {ECO:0000269|PubMed:10781083, ECO:0000269|PubMed:14517253, ECO:0000269|PubMed:14612388}. Note=Closely associated with pericentric heterochromatin. {ECO:0000269|PubMed:10781083, ECO:0000269|PubMed:14517253, ECO:0000269|PubMed:14612388}.
uniprot
proteins