Cactin
entrez
70312
canonical
uniprot
Q9CS00
canonical
ensembl
ENSMUSG00000034889
resolver
ensp
ENSMUSP00000059533
resolver
enst
ENSMUST00000050867
resolver
genesymbol
Cactin
resolver
genesymbol_syn
2510012J08Rik
resolver
uniprot
A1L013
resolver
uniprot_entry
A1L013_MOUSE
resolver
uniprot_entry
CATIN_MOUSE
resolver
amino_acid_sequence
MRGAGRQMGRDSRSRSRSVGRRGRKQRSRSRGRSRSRSRSRSRSRSRSRSRSRSHGRSSRRRREHERRRERKRRSRGRRSDSEGEQRQKSRRRSQSLRPPRWHSQNQSSCSDSGEERAQGSWARKGHRRSWSPGSSASSLDSPRRSRSPGTATLALSQQQSLQERLRLREERKQQEELLKAFETPEEKRARRLAKKEAKERKKREKMGWGEEYMGYTNTDNPFGDNNLLGTFIWNKALEKKGISHLEEKELKERNKRIQEDNRLELQKVKQLRLEREREKAMREQELELLQREKEAEHFKTWEEQEDSFHLRQAKLRSKIRIRDGRAKPIDLLAKYISAEDDDLAVEMHEPYTFLNGLTVADMEDLLEDIQVYMELEQGKNVDFWRDMTTITEDEIAKLRKLEASGKGPGERREGVNASVSSDVQSVFKGKTYNQLQVIFQGIEGKIRAGGPNLDMGYWESLLQQLRAHMARARLRERHQDVLRQKLFKLKQEQGVESEPLFPILKSEPSAAHSPEPEERPPSPGTSVDPVEPVEPEEATAPGEAEGEAEGEAVLMEEDLIQQSLADYDAGRYSPRLLTAHELPLDAHVLEPHEDLQRLQLSRQQLQATGDASESAEDIFFRRAREGMGQDEAQFSVEMPLGGRAYLWADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIRKRATPEYFLEACADNRDFAILRFHAGPPYEDIAFKIVSREWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR
uniprot
proteins
function
FUNCTION: Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (By similarity). Required for the splicing of CDCA5/Sororin, a regulator of sister chromatid cohesion (By similarity). Involved in the regulation of innate immune response (By similarity). Acts as a negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (By similarity). Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (By similarity). {ECO:0000250|UniProtKB:Q8WUQ7}.
uniprot
proteins
mass_dalton
90661
uniprot
proteins
protein_family
CACTIN family
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20829348
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
772
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WUQ7}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8WUQ7}. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus (By similarity). {ECO:0000250|UniProtKB:Q8WUQ7}.
uniprot
proteins