Cst5
entrez
58214
canonical
uniprot
Q9JM84
canonical
ensembl
ENSMUSG00000033156
resolver
ensp
ENSMUSP00000043520
resolver
genesymbol
Cst5
resolver
genesymbol_syn
Cst10
resolver
genesymbol_syn
DD72
resolver
uniprot
A2ART7
resolver
uniprot_entry
CSTD_MOUSE
resolver
uniprot_sec
A2ART7
resolver
amino_acid_sequence
MASLLSPSMPVLAAVALTLTLAVIPEASTNAEAKQVVLGGVEPADPKDKEVQKVVKFAVRTYNDMDNDLYLSKPIRLMSASQQVVAGKNYYLKIELGRTTCTKTESNLVDCPFNEQPDQQKRVICNFQINVAPWLNKMSMTNFNCYNF
uniprot
proteins
function
FUNCTION: May play a role in the last steps of the chondrocyte differentiation pathway as an inducer of maturation (PubMed:13679380). Induces chondrocyte calcification during endochondral ossification by playing a role in the transcriptional inhibition of ENPP1, a generator of pyrophosphate which inhibits calcification (PubMed:16680148). Possibly impairs the binding of a transcription factor to the ENPP1 promoter (PubMed:16680148). Unlike other cystatins, does not have thiol protease inhibitor activity (PubMed:16680148). {ECO:0000269|PubMed:13679380, ECO:0000269|PubMed:16680148}.
uniprot
proteins
mass_dalton
16451
uniprot
proteins
protein_family
Cystatin family
uniprot
proteins
pubmed
11856874
uniprot
proteins
pubmed
13679380
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16680148
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
148
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:13679380}.
uniprot
proteins