Mvk
entrez
17855
canonical
uniprot
Q9R008
canonical
ensembl
ENSMUSG00000041939
resolver
ensp
ENSMUSP00000036971
resolver
ensp
ENSMUSP00000107858
resolver
ensp
ENSMUSP00000142758
resolver
ensp
ENSMUSP00000143347
resolver
ensp
ENSMUSP00000249670
resolver
ensp
ENSMUSP00000249691
resolver
enst
ENSMUST00000043760
resolver
enst
ENSMUST00000112239
resolver
enst
ENSMUST00000124260
resolver
enst
ENSMUST00000137167
resolver
genesymbol
Mvk
resolver
uniprot
A0A0G2JEG0
resolver
uniprot
A0A0G2JFX8
resolver
uniprot
F6QCK0
resolver
uniprot
Q3UEB4
resolver
uniprot_entry
A0A0G2JEG0_MOUSE
resolver
uniprot_entry
A0A0G2JFX8_MOUSE
resolver
uniprot_entry
F6QCK0_MOUSE
resolver
uniprot_entry
KIME_MOUSE
resolver
uniprot_entry
Q3UEB4_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Farnesyl pyrophosphate and geranyl pyrophosphate inhibit mevalonate kinase activity by binding competitively at the ATP-binding sites. {ECO:0000250|UniProtKB:Q03426}.
uniprot
proteins
amino_acid_sequence
MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVGMLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGDPVRQALGL
uniprot
proteins
ec_number
2.7.1.36
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis. {ECO:0000250|UniProtKB:Q03426}.
uniprot
proteins
mass_dalton
41877
uniprot
proteins
pathway_participation
PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
uniprot
proteins
protein_family
GHMP kinase family
uniprot
proteins
protein_family
Mevalonate kinase subfamily
uniprot
proteins
pubmed
10401001
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P17256}. Peroxisome {ECO:0000250|UniProtKB:P17256}.
uniprot
proteins