Nosip
entrez
66394
canonical
uniprot
Q9D6T0
canonical
ensembl
ENSMUSG00000003421
resolver
ensp
ENSMUSP00000003513
resolver
ensp
ENSMUSP00000103460
resolver
ensp
ENSMUSP00000202268
resolver
ensp
ENSMUSP00000202270
resolver
ensp
ENSMUSP00000202271
resolver
ensp
ENSMUSP00000202274
resolver
ensp
ENSMUSP00000202283
resolver
genesymbol
Nosip
resolver
uniprot
Q9D8J9
resolver
uniprot_entry
NOSIP_MOUSE
resolver
uniprot_sec
Q9D8J9
resolver
amino_acid_sequence
MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKREIARQVKAYEKQRGARREEQKELQRAAAQDQVRGFLEKEAAIVSRPLNPFMPKAATLPNTEGEQPGPSVGPVGKDKDKALPSFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTSVRFTQLDDSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVNGDTLTERDIIVLQRGGTGFAGSGVKLQAEMSRPVMQA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (PubMed:25546391). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity). {ECO:0000250|UniProtKB:Q9Y314, ECO:0000269|PubMed:25546391}.
uniprot
proteins
mass_dalton
33209
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
NOSIP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25546391
uniprot
proteins
sequence_length
301
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y314}. Nucleus {ECO:0000250|UniProtKB:Q9Y314}. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle. {ECO:0000250|UniProtKB:Q9Y314}.
uniprot
proteins