SRSF10
entrez
10772
canonical
uniprot
O75494
canonical
ensembl
ENSG00000188529
resolver
ensp
ENSP00000342913
resolver
ensp
ENSP00000344149
resolver
ensp
ENSP00000363576
resolver
ensp
ENSP00000363577
resolver
ensp
ENSP00000388991
resolver
ensp
ENSP00000419813
resolver
ensp
ENSP00000420195
resolver
ensp
ENSP00000645741
resolver
enst
ENST00000374453
resolver
genesymbol
SRSF10
resolver
genesymbol_syn
FUSIP1
resolver
genesymbol_syn
FUSIP2
resolver
genesymbol_syn
SFRS13A
resolver
genesymbol_syn
TASR
resolver
hgnc
HGNC:16713
resolver
uniprot
A0A0S2Z504
resolver
uniprot
A6NFM6
resolver
uniprot
A6NI42
resolver
uniprot
A6NIU7
resolver
uniprot
B3KNY6
resolver
uniprot
B4DJP9
resolver
uniprot
O60572
resolver
uniprot
Q5JRH9
resolver
uniprot
Q5JRI0
resolver
uniprot
Q5JRI1
resolver
uniprot
Q5JRI2
resolver
uniprot
Q5JRI3
resolver
uniprot
Q5JRI4
resolver
uniprot
Q96G09
resolver
uniprot
Q96P17
resolver
uniprot_entry
A0A0S2Z504_HUMAN
resolver
uniprot_entry
B3KNY6_HUMAN
resolver
uniprot_entry
Q5JRI1_HUMAN
resolver
uniprot_entry
SRS10_HUMAN
resolver
uniprot_sec
A6NFM6
resolver
uniprot_sec
A6NI42
resolver
uniprot_sec
A6NIU7
resolver
uniprot_sec
B4DJP9
resolver
uniprot_sec
O60572
resolver
uniprot_sec
Q5JRH9
resolver
uniprot_sec
Q5JRI0
resolver
uniprot_sec
Q5JRI2
resolver
uniprot_sec
Q5JRI3
resolver
uniprot_sec
Q5JRI4
resolver
uniprot_sec
Q96G09
resolver
uniprot_sec
Q96P17
resolver
amino_acid_sequence
MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHSDNDRFKHRNRSFSRSKSNSRSRSKSQPKKEMKAKSRSRSASHTKTRGTSKTDSKTHYKSGSRYEKESRKKEPPRSKSQSRSQSRSRSKSRSRSWTSPKSSGH
uniprot
proteins
function
FUNCTION: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:12419250, ECO:0000269|PubMed:14765198, ECO:0000269|PubMed:26876937}.
uniprot
proteins
mass_dalton
31301
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock. {ECO:0000269|PubMed:12419250, ECO:0000269|PubMed:14765198}.
uniprot
proteins
protein_family
Splicing factor SR family
uniprot
proteins
pubmed
10779324
uniprot
proteins
pubmed
11684676
uniprot
proteins
pubmed
11891055
uniprot
proteins
pubmed
12419250
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14765198
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26876937
uniprot
proteins
pubmed
9774382
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:26876937}. Cytoplasm {ECO:0000269|PubMed:11684676}.
uniprot
proteins