Abhd16a
entrez
193742
canonical
uniprot
Q9Z1Q2
canonical
ensembl
ENSMUSG00000007036
resolver
ensp
ENSMUSP00000007251
resolver
ensp
ENSMUSP00000267907
resolver
ensp
ENSMUSP00000267909
resolver
ensp
ENSMUSP00000267919
resolver
ensp
ENSMUSP00000267921
resolver
enst
ENSMUST00000007251
resolver
genesymbol
Abhd16a
resolver
genesymbol_syn
Bat5
resolver
genesymbol_syn
Ng26
resolver
uniprot_entry
ABHGA_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Specifically inhibited by alpha-alkylidene-beta-lactone KC01 ((Z)-6-(2-Oxo-4-tridecyloxetan-3-ylidene)hexanamide). {ECO:0000269|PubMed:25580854}.
uniprot
proteins
amino_acid_sequence
MAKLLSCVLGPRLYKIYRERDTDRAASSVPETPTAVPAASSSSWDTYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSAENKRQLANYNFDFRSWPVDFHWEEPSSRKGSRGGPSRRGVALLRPEPLHRGTADTFLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIVIYAWSIGGFTATWAAMSYPDISAVILDASFDDLVPLALKVMPDSWRALVTRTVRQHLNLNNSEQLCRFQGPVLLVRRTKDEIITTTVPEDIMSNRGNDLLLKLLQFRYPRVMVEEGLRAVRQWLEASSQLEEASIYSRWEVEEDWCVSVLRSYQAEHGPDFPWSVGEDMSADGRRQLALFLARKHLHNFEATHCTPLPAQHFQMPWHL
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
ec_number
3.1.1.23
uniprot
proteins
function
FUNCTION: Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (PubMed:25580854). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (PubMed:25580854). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (By similarity). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (PubMed:25290914). {ECO:0000250|UniProtKB:O95870, ECO:0000269|PubMed:25290914, ECO:0000269|PubMed:25580854}.
uniprot
proteins
mass_dalton
63086
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
ABHD16 family
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25290914
uniprot
proteins
pubmed
25580854
uniprot
proteins
sequence_length
558
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:25580854}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 60..80; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins