Rheb
entrez
26954
canonical
uniprot
Q62639
canonical
ensembl
ENSRNOG00000050578
resolver
ensembl
ENSRNOG00055022385
resolver
ensembl
ENSRNOG00060023259
resolver
ensembl
ENSRNOG00065004059
resolver
ensp
ENSRNOP00000063915
resolver
ensp
ENSRNOP00055031296
resolver
ensp
ENSRNOP00060033296
resolver
ensp
ENSRNOP00065004255
resolver
enst
ENSRNOT00000071737
resolver
enst
ENSRNOT00055038470
resolver
enst
ENSRNOT00060040324
resolver
enst
ENSRNOT00065005931
resolver
genesymbol
Rheb
resolver
uniprot_entry
RHEB_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Alternates between an inactive form bound to GDP and an active form bound to GTP. Inactivated by the TSC-TBC complex via the GTPase activating protein (GAP) domain of TSC2. Autoinhibited by Tyr-35, which constrains the active site conformation, restricting the access of the catalytic Asp-65 to the nucleotide-binding pocket (By similarity). {ECO:0000250|UniProtKB:Q15382}.
uniprot
proteins
amino_acid_sequence
MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKIDGAASQGKSSCSVM
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes. In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1. Has low intrinsic GTPase activity. {ECO:0000250|UniProtKB:Q15382}.
uniprot
proteins
mass_dalton
20479
uniprot
proteins
post_translational_modification
PTM: Farnesylation is important for efficiently activating mTORC1-mediated signaling. {ECO:0000269|PubMed:20685651}.; PTM: Polyubiquitinated in response to amino acid, promoting its interaction with MTOR and mTORC1 activation. Deubiquitination by ATXN3 promotes recruitment of the TSC-TBC complex and RHEB inactivation by TSC2. Monoubiquitinated at Lys-8 by RNF152, promoting its association with the TSC-TBC complex. Deubiquitinated at Lys-8 by USP4, promoting mTORC1 activation. {ECO:0000250|UniProtKB:Q15382}.; PTM: Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation. {ECO:0000250|UniProtKB:Q921J2}.
uniprot
proteins
protein_family
Rheb family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20685651
uniprot
proteins
pubmed
8206940
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250|UniProtKB:Q15382}; Lipid-anchor {ECO:0000250|UniProtKB:Q15382}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15382}. Lysosome membrane {ECO:0000250|UniProtKB:Q15382}; Lipid-anchor {ECO:0000250|UniProtKB:Q15382}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15382}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q15382}; Lipid-anchor {ECO:0000250|UniProtKB:Q15382}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15382}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15382}; Lipid-anchor {ECO:0000250|UniProtKB:Q15382}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15382}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q15382}. Note=Farnesylation is required for recruitment to lysosomal membranes, where it activates the mTORC1 complex. {ECO:0000250|UniProtKB:Q15382}.
uniprot
proteins