ADRB1
entrez
153
canonical
uniprot
P08588
canonical
ensembl
ENSG00000043591
resolver
ensp
ENSP00000358301
resolver
enst
ENST00000369295
resolver
genesymbol
ADRB1
resolver
genesymbol_syn
ADRB1R
resolver
genesymbol_syn
B1AR
resolver
hgnc
HGNC:285
resolver
uniprot
B0LPE2
resolver
uniprot
Q5T5Y4
resolver
uniprot
Q9UKG7
resolver
uniprot
Q9UKG8
resolver
uniprot_entry
ADRB1_HUMAN
resolver
uniprot_sec
B0LPE2
resolver
uniprot_sec
Q5T5Y4
resolver
uniprot_sec
Q9UKG7
resolver
uniprot_sec
Q9UKG8
resolver
amino_acid_sequence
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for catecholamines that couples to G(s) proteins to activate adenylate cyclase and cAMP-dependent pathway (PubMed:10212248, PubMed:12391161, PubMed:15358775). Binds epinephrine and norepinephrine with approximately equal affinity (PubMed:33093660). Mediates the activation of Ras via binding with cAMP-dependent RAPGEF2 (PubMed:12391161). As part of the sympathetic nervous system, plays a role in the physiologic regulation of cardiac functions such as stimulation of cardiomyocyte contraction (PubMed:11052857). Also delivers proapoptotic signals in cardiomyocytes (By similarity). Involved in the regulation of sleep/wake behaviors (PubMed:11854867, PubMed:31473062). {ECO:0000250|UniProtKB:P34971, ECO:0000269|PubMed:10212248, ECO:0000269|PubMed:11052857, ECO:0000269|PubMed:11854867, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:31473062, ECO:0000269|PubMed:33093660}.
uniprot
proteins
mass_dalton
51224
uniprot
proteins
mutagenesis
MUTAGEN 199; /note="W->Y: Decreased noradrenaline affinity."; /evidence="ECO:0000269|PubMed:33093660"; MUTAGEN 347; /note="K->H: Decreased noradrenaline affinity."; /evidence="ECO:0000269|PubMed:33093660"; MUTAGEN 359; /note="F->Y: Decreased noradrenaline affinity."; /evidence="ECO:0000269|PubMed:33093660"; MUTAGEN 474; /note="E->A,D: Loss of interaction with GOPC."; /evidence="ECO:0000269|PubMed:15358775"; MUTAGEN 474; /note="E->K: Loss of interaction with GOPC; when associated with A-477."; /evidence="ECO:0000269|PubMed:15358775"; MUTAGEN 475; /note="S->A: Loss of interaction with GOPC. Loss of interaction with RAPGEF2. Abolishes agonist-induced Ras activation."; /evidence="ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:15358775"; MUTAGEN 475; /note="S->D: Loss of interaction with RAPGEF2."; /evidence="ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:15358775"; MUTAGEN 475; /note="S->T: Partial loss of interaction with GOPC."; /evidence="ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:15358775"; MUTAGEN 476; /note="K->A: Partial loss of interaction with GOPC."; /evidence="ECO:0000269|PubMed:15358775"; MUTAGEN 477; /note="V->A,F,L,I,M: Loss of interaction with GOPC."; /evidence="ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:15358775"; MUTAGEN 477; /note="V->A: Loss of interaction with RAPGEF2. Abolishes agonist-induced Ras activation."; /evidence="ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:15358775
uniprot
proteins
post_translational_modification
PTM: Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
uniprot
proteins
protein_family
ADRB1 sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10212248
uniprot
proteins
pubmed
10477438
uniprot
proteins
pubmed
11052857
uniprot
proteins
pubmed
11854867
uniprot
proteins
pubmed
12391161
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15358775
uniprot
proteins
pubmed
21540189
uniprot
proteins
pubmed
2825170
uniprot
proteins
pubmed
31473062
uniprot
proteins
pubmed
33093660
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P18090}; Multi-pass membrane protein {ECO:0000269|PubMed:33093660}. Note=Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane (By similarity). Found in the Golgi upon GOPC overexpression (PubMed:15358775). Localized to early endosomes during endocytic trafficking (PubMed:21540189). {ECO:0000250|UniProtKB:P18090, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:21540189}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..81; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:33093660, ECO:0007744|PDB:7BU6"; TRANSMEM 96..121; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:33093660, ECO:0007744|PDB:7BU6"; TRANSMEM 129..154; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:33093660, ECO:0007744|PDB:7BU6"; TRANSMEM 177..199; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:33093660, ECO:0007744|PDB:7BU6"; TRANSMEM 222..245; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:33093660, ECO:0007744|PDB:7BU6"; TRANSMEM 324..349; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:33093660, ECO:0007744|PDB:7BU6"; TRANSMEM 358..377; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:33093660, ECO:0007744|PDB:7BU6
uniprot
proteins