Aup1
entrez
11993
canonical
uniprot
P70295
canonical
ensembl
ENSMUSG00000068328
resolver
ensp
ENSMUSP00000090281
resolver
enst
ENSMUST00000092618
resolver
genesymbol
Aup1
resolver
uniprot
F8WI32
resolver
uniprot
I6L970
resolver
uniprot
Q3TBX5
resolver
uniprot
Q3U3K9
resolver
uniprot_entry
AUP1_MOUSE
resolver
uniprot_entry
F8WI32_MOUSE
resolver
uniprot_entry
I6L970_MOUSE
resolver
uniprot_entry
Q3TBX5_MOUSE
resolver
uniprot_entry
Q3U3K9_MOUSE
resolver
amino_acid_sequence
MEPPPAPGPERLFDSHRLPSDGFLLLALLLYAPVGLCLLVLRLFLGLHVFLVSCALPDSVLRRFVVRTMCAVLGLVARQEDSGLRDHRVRVLISNHVTPFDHNIVNLLTTCSTPLLNSPPSFVCWSRGFMEMDRRVELVESLKKFCASTRLPPTPLLLFPEEEATNGREGLLRFSSWPFSIQDVVQPLTLQVQRPLVSVTVSDASWVSELLWSLFVPFTVYQVRWLHPIRRQLGEESEEFALRVQQLVAKELGQIGTRLTPADKAEHMKRQRHPRLRPQSVQSSFPSPPSPSSDVQLTTLAHRVKEVLPHVPLNVIQRDLARTGCVDLTITNLLEGAVAFMPEDVTEGSQSPPAPSAPKFPSSGLATPQPTALTFAKSSWARQESLQERKQALYEYARRRFRERQAQEAE
uniprot
proteins
function
FUNCTION: Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (By similarity). Plays a role in lipid droplet formation (By similarity). Induces lipid droplet clustering (By similarity). Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (By similarity). Also required for the degradation of INSIG1, SREBF1 and SREBF2 (By similarity). Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB (By similarity). {ECO:0000250|UniProtKB:Q9Y679}.
uniprot
proteins
mass_dalton
46121
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated and diubiquitinated. {ECO:0000250|UniProtKB:Q9Y679}.
uniprot
proteins
protein_family
AUP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8812468
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y679}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Y679}. Lipid droplet {ECO:0000250|UniProtKB:Q9Y679}.
uniprot
proteins