Grk3
entrez
320129
canonical
uniprot
Q3UYH7
canonical
ensembl
ENSMUSG00000042249
resolver
ensp
ENSMUSP00000070445
resolver
ensp
ENSMUSP00000142968
resolver
ensp
ENSMUSP00000292236
resolver
enst
ENSMUST00000065167
resolver
enst
ENSMUST00000197888
resolver
genesymbol
Grk3
resolver
genesymbol_syn
Adrbk2
resolver
uniprot
A0A0G2JF01
resolver
uniprot
F8VPM8
resolver
uniprot
Q8BVT9
resolver
uniprot_entry
A0A0G2JF01_MOUSE
resolver
uniprot_entry
GRK3_MOUSE
resolver
uniprot_entry
Q8BVT9_MOUSE
resolver
uniprot_sec
F8VPM8
resolver
amino_acid_sequence
MADLEAVLADVSYLMAMEKSKTAPAARASKKVVLPEPSIRSVMQRYLAERNEITFDKIFNQKIGFLLFKDFCLNEIGEAVPQVKFYEEIKEYEKLDNEEDRLRRSRQMYDAYIMRELLSSTHQFSKQAVEHVQSHLSKKQVTATLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLSMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRVKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDMHYHLSQHGVFSEKEMRFYASEIILGLEHMHTCFVVYRDLKPANILLDEYGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTCYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVQLPDAFSPELRSLLEGLLQRDVSQRLGCGGGGARELKEHIFFKGIDWQHVYLRKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQDLYKNFPLVISERWQQEVVETIYDAVNADTDKIEARRKAKNKQLGQEEDYAMGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQSLLTMEQIMSVEETQIKDRKCILLRIKGGKQFVLQCESDPEFAQWLKELTCTFNEAQRLLRRAPKFLNKPRAAILEFSKPPLCHRNSSGL
uniprot
proteins
ec_number
2.7.11.15
uniprot
proteins
ec_number
2.7.11.16
uniprot
proteins
function
FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:33886552, PubMed:38883814). Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:33886552, PubMed:38883814). Phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors (By similarity). Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (By similarity). Positively regulates ciliary smoothened (SMO) signaling pathway by mediating phosphorylation of SMO, facilitating SMO trafficking into the cilium and the stimulation of SMO activity (PubMed:33886552). {ECO:0000250|UniProtKB:P26819, ECO:0000250|UniProtKB:P35626, ECO:0000269|PubMed:33886552, ECO:0000269|PubMed:38883814}.
uniprot
proteins
mass_dalton
79657
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. {ECO:0000250|UniProtKB:P35626}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
GPRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33886552
uniprot
proteins
pubmed
38883814
uniprot
proteins
sequence_length
688
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynapse {ECO:0000250|UniProtKB:P26819}. Presynapse {ECO:0000250|UniProtKB:P26819}.
uniprot
proteins