CYTH1
entrez
9267
canonical
uniprot
Q15438
canonical
ensembl
ENSG00000108669
resolver
ensp
ENSP00000389095
resolver
ensp
ENSP00000465665
resolver
ensp
ENSP00000465940
resolver
ensp
ENSP00000466512
resolver
ensp
ENSP00000467052
resolver
ensp
ENSP00000670633
resolver
enst
ENST00000589768
resolver
genesymbol
CYTH1
resolver
genesymbol_syn
D17S811E
resolver
genesymbol_syn
PSCD1
resolver
hgnc
HGNC:9501
resolver
uniprot
A6NFW7
resolver
uniprot
B7Z1T4
resolver
uniprot
B7Z9W0
resolver
uniprot
K7ENQ8
resolver
uniprot
Q9P123
resolver
uniprot
Q9P124
resolver
uniprot_entry
B7Z9W0_HUMAN
resolver
uniprot_entry
CYH1_HUMAN
resolver
uniprot_entry
K7ENQ8_HUMAN
resolver
uniprot_sec
A6NFW7
resolver
uniprot_sec
B7Z1T4
resolver
uniprot_sec
Q9P123
resolver
uniprot_sec
Q9P124
resolver
amino_acid_sequence
MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH
uniprot
proteins
function
FUNCTION: Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. {ECO:0000250|UniProtKB:Q9QX11, ECO:0000269|PubMed:10652308, ECO:0000269|PubMed:29420262, ECO:0000269|PubMed:9653114}.
uniprot
proteins
mass_dalton
46413
uniprot
proteins
mutagenesis
MUTAGEN 157; /note="E->A,K: Reduces guanine exchange factor activity by over 90%."; /evidence="ECO:0000269|PubMed:9653114"; MUTAGEN 187; /note="Y->A: Reduces guanine exchange factor activity by over 90%."; /evidence="ECO:0000269|PubMed:9653114"; MUTAGEN 195; /note="M->A: Reduces guanine exchange factor activity by over 90%."; /evidence="ECO:0000269|PubMed:9653114
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by SCF(FBXW11) E3 ubiquitin-protein ligase complex. Ubiquitination induces proteasomal degradation. {ECO:0000269|PubMed:29420262}.
uniprot
proteins
pubmed
10652308
uniprot
proteins
pubmed
10748148
uniprot
proteins
pubmed
11867758
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1511013
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17398095
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
29420262
uniprot
proteins
pubmed
9653114
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17398095}; Peripheral membrane protein {ECO:0000269|PubMed:17398095}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9QX11}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9QX11}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9QX11}. Note=Colocalized with TJP1 during epithelial polarization. {ECO:0000250|UniProtKB:Q9QX11}.
uniprot
proteins