Aptx
entrez
66408
canonical
uniprot
Q7TQC5
canonical
ensembl
ENSMUSG00000028411
resolver
ensp
ENSMUSP00000030119
resolver
ensp
ENSMUSP00000124264
resolver
ensp
ENSMUSP00000279393
resolver
ensp
ENSMUSP00000279397
resolver
ensp
ENSMUSP00000279399
resolver
genesymbol
Aptx
resolver
uniprot
Q8BPA7
resolver
uniprot
Q8C2B5
resolver
uniprot
Q8K3D1
resolver
uniprot
Q9CQ59
resolver
uniprot_entry
APTX_MOUSE
resolver
uniprot_sec
Q8BPA7
resolver
uniprot_sec
Q8C2B5
resolver
uniprot_sec
Q8K3D1
resolver
uniprot_sec
Q9CQ59
resolver
amino_acid_sequence
MPEAVAKMRVCWLVRQDSRHQRIKLPHLEAVVIGRSPETKITDKKCSRQQVQLKAECNKGYVKVQQMGVNPTSIDSGVIGKDQEKKLLPGQVLHMVNGLYPYIVEFEEVAESPNLTQRKRKRSDCDSEEMEAESGTGLAPGSSPSQCSVSPKKDKNGATKKESLGHWSQGLKMSMKDPKMQVYKDDQVVVIKDKYPKARHHWLVLPWASISSLKVVTSEHLELLKHMHAVGEKVIADFAGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIKMVQEAGRVTVKDGTCELLKLPLRCHECQQLLPSIPQLKEHLRKHWGG
uniprot
proteins
ec_number
3.6.1.71
uniprot
proteins
ec_number
3.6.1.72
uniprot
proteins
function
FUNCTION: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). {ECO:0000250|UniProtKB:O74859, ECO:0000250|UniProtKB:Q7Z2E3, ECO:0000269|PubMed:16964241}.
uniprot
proteins
mass_dalton
38723
uniprot
proteins
pubmed
11586300
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16964241
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
342
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q7Z2E3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q7Z2E3}. Note=Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage. Colocalizes with MDC1 at sites of DNA double-strand breaks. Interaction with NCL is required for nucleolar localization (By similarity). {ECO:0000250|UniProtKB:Q7Z2E3}.
uniprot
proteins