RNF5
entrez
6048
canonical
uniprot
Q99942
canonical
ensembl
ENSG00000183574
resolver
ensembl
ENSG00000204308
resolver
ensembl
ENSG00000223767
resolver
ensembl
ENSG00000225452
resolver
ensembl
ENSG00000227277
resolver
ensembl
ENSG00000228405
resolver
ensembl
ENSG00000228907
resolver
ensp
ENSP00000364235
resolver
ensp
ENSP00000387879
resolver
ensp
ENSP00000388795
resolver
ensp
ENSP00000401172
resolver
ensp
ENSP00000413131
resolver
ensp
ENSP00000415127
resolver
ensp
ENSP00000415784
resolver
enst
ENST00000375094
resolver
enst
ENST00000413786
resolver
enst
ENST00000432616
resolver
enst
ENST00000445885
resolver
enst
ENST00000449794
resolver
enst
ENST00000453473
resolver
enst
ENST00000456167
resolver
genesymbol
RNF5
resolver
genesymbol_syn
G16
resolver
genesymbol_syn
NG2
resolver
genesymbol_syn
RMA1
resolver
hgnc
HGNC:10068
resolver
uniprot
A2BFI6
resolver
uniprot
B2R4K3
resolver
uniprot
Q0VDB7
resolver
uniprot
Q9UMQ2
resolver
uniprot_entry
RNF5_HUMAN
resolver
uniprot_sec
A2BFI6
resolver
uniprot_sec
B2R4K3
resolver
uniprot_sec
Q0VDB7
resolver
uniprot_sec
Q9UMQ2
resolver
amino_acid_sequence
MAAAEEEDGGPEGPNRERGGAGATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPERQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPESRGGFQPFGDTGGFHFSFGVGAFPFGFFTTVFNAHEPFRRGTGVDLGQGHPASSWQDSLFLFLAIFFFFWLLSI
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins (PubMed:11329381, PubMed:12861019, PubMed:16176924, PubMed:19269966, PubMed:19285439). May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 (PubMed:11329381). Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin (PubMed:12861019). Catalyzes ubiquitination of Salmonella type III secreted protein sopA (PubMed:16176924). Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N (PubMed:19269966). Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses (PubMed:19285439). Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy (PubMed:23093945). {ECO:0000269|PubMed:11329381, ECO:0000269|PubMed:12861019, ECO:0000269|PubMed:16176924, ECO:0000269|PubMed:19269966, ECO:0000269|PubMed:19285439, ECO:0000269|PubMed:23093945}.
uniprot
proteins
mass_dalton
19881
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="C->S: Loss of E3 ubiquitin-protein ligase activity."; /evidence="ECO:0000269|PubMed:11329381
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:19269966, ECO:0000269|PubMed:19285439, ECO:0000269|PubMed:23093945}.
uniprot
proteins
protein_family
RNF5 family
uniprot
proteins
pubmed
11329381
uniprot
proteins
pubmed
12861019
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16176924
uniprot
proteins
pubmed
19269966
uniprot
proteins
pubmed
19285439
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23093945
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25489052
uniprot
proteins
pubmed
9533025
uniprot
proteins
sequence_length
180
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9533025}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:19285439}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19285439}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles. {ECO:0000269|PubMed:9533025}.
uniprot
proteins
transmembrane_region
TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins