Catsper2
entrez
366174
canonical
uniprot
Q6AXP6
canonical
ensembl
ENSRNOG00000023064
resolver
ensp
ENSRNOP00000038712
resolver
ensp
ENSRNOP00000098911
resolver
enst
ENSRNOT00000030019
resolver
genesymbol
Catsper2
resolver
uniprot_entry
CTSR2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by intracellular alkalinization. {ECO:0000250|UniProtKB:Q96P56}.
uniprot
proteins
amino_acid_sequence
MAHERGHLQLPRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPACQKKLMLGDQEQLVRFSIRARRMGHITHAQRLLSRLRVRCGGRPPLSLWAGWVLDSSIFSNFIISLIFLNTFVLMVEIELMNSTNTSLWPLKLALEVTDWFILLSFIVEILLMWLASFFLFWKNAWSVFDFVVTMLSLLPEFVVLIGVSADSVWLQLLRVSRVLRSLKLFARFPQIKVILLALVRALKSMTFLLMLLLIFFYVFAVAGVYFFKEYSRSTIENLEYNMFFSDLLNSLVTVFILFTLDHWYAVLQDVWKVPEASRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRNELHEEMTHLEVQYKADIFKRRIIQRRQQSESLRGTSQGKVSEDITETSEATDEEKSEAEESEEEKSEEEKSDVEKSDEEKNDEEKSDEEENDEEKSDVEKSDEEKNDEEKGYTEKVYSGRTFVERSYAERSFAGKAENEKVQKELKEKAYPGSPPNSSSHDEAFAADDTYLENLDWETLVHENLPGLMDMDQDDRVVWPRDSLFRYFELLESLQYNLEERKRLQEFAVQALMNFEDK
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. {ECO:0000250|UniProtKB:A2ARP9}.
uniprot
proteins
mass_dalton
68266
uniprot
proteins
protein_family
Cation channel sperm-associated (TC 1.A.1.19) family
uniprot
proteins
pubmed
11675491
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
584
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:A2ARP9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A2ARP9}.
uniprot
proteins
transmembrane_region
TRANSMEM 107..129; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:A2ARP9"; TRANSMEM 139..164; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:A2ARP9"; TRANSMEM 174..198; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:A2ARP9"; TRANSMEM 202..220; /note="Helical; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:A2ARP9"; TRANSMEM 238..260; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:A2ARP9"; TRANSMEM 313..339; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:A2ARP9
uniprot
proteins