C0HLZ6
uniprot
C0HLZ6
canonical
amino_acid_sequence
MPVLPGTQRYPHQRRRFQAAGGGAESGKRGSEEAPGVAWSGSESGRDAATPAW
uniprot
proteins
function
FUNCTION: Blocks the binding of HNRNPA1 to the intronic sequences flanking exon 9 of the PKM gene by competitively binding to the HNRNPA1 RGG-box motif (PubMed:28985503). This inhibits inclusion of exon 9 and promotes inclusion of exon 10, suppressing formation of the PKM M2 isoform and promoting production of the M1 isoform (PubMed:28985503). Also suppresses HNRNPA1-mediated processing of microRNA 18a (miR-18a) (PubMed:28985503). Promotes MYC stability through interaction with IGF2BP2 (PubMed:34457052). {ECO:0000269|PubMed:28985503, ECO:0000269|PubMed:34457052}.
uniprot
proteins
mass_dalton
5567
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
28985503
uniprot
proteins
pubmed
34457052
uniprot
proteins
sequence_length
53
uniprot
proteins