RAB3D
entrez
9545
canonical
uniprot
O95716
canonical
ensembl
ENSG00000105514
resolver
ensp
ENSP00000222120
resolver
ensp
ENSP00000466000
resolver
enst
ENST00000222120
resolver
enst
ENST00000589655
resolver
genesymbol
RAB3D
resolver
genesymbol_syn
GOV
resolver
genesymbol_syn
RAB16
resolver
hgnc
HGNC:9779
resolver
uniprot
A0A024R7G2
resolver
uniprot_entry
A0A024R7G2_HUMAN
resolver
uniprot_entry
RAB3D_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation. {ECO:0000250|UniProtKB:P20336}.
uniprot
proteins
amino_acid_sequence
MASAGDTQAGPRDAADQNFDYMFKLLLIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTVYRHDKRIKLQIWDTAGQERYRTITTAYYRGAMGFLLMYDIANQESFAAVQDWATQIKTYSWDNAQVILVGNKCDLEDERVVPAEDGRRLADDLGFEFFEASAKENINVKQVFERLVDVICEKMNESLEPSSSSGSNGKGPAVGDAPAPQPSSCSC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB3D may be involved in the insulin-induced exocytosis of GLUT4-containing vesicles in adipocytes (By similarity). {ECO:0000250|UniProtKB:P20336, ECO:0000250|UniProtKB:P35276}.
uniprot
proteins
mass_dalton
24267
uniprot
proteins
mutagenesis
MUTAGEN 86; /note="T->A: Loss of phosphorylation. Reduced binding of CHM and CHML binding."; /evidence="ECO:0000269|PubMed:29125462"; MUTAGEN 86; /note="T->E: Phosphomimetic mutant. Loss of CHM and CHML binding."; /evidence="ECO:0000269|PubMed:29125462
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM and CHML. {ECO:0000269|PubMed:29125462}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10023084
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
29125462
uniprot
proteins
pubmed
35871249
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
uniprot
proteins