Ccl7
entrez
20306
canonical
uniprot
Q03366
canonical
ensembl
ENSMUSG00000035373
resolver
ensp
ENSMUSP00000021011
resolver
enst
ENSMUST00000021011
resolver
genesymbol
Ccl7
resolver
genesymbol_syn
Fic
resolver
genesymbol_syn
MARC
resolver
genesymbol_syn
Mcp3
resolver
genesymbol_syn
Scya7
resolver
uniprot
A9Z1Z1
resolver
uniprot_entry
A9Z1Z1_MOUSE
resolver
uniprot_entry
CCL7_MOUSE
resolver
amino_acid_sequence
MRISATLLCLLLIAAAFSIQVWAQPDGPNASTCCYVKKQKIPKRNLKSYRRITSSRCPWEAVIFKTKKGMEVCAEAHQKWVEEAIAYLDMKTPTPKP
uniprot
proteins
function
FUNCTION: Chemotactic factor that plays an important role in immune regulation. Attracts monocytes, eosinophils, basophils, and T-cells to sites of inflammation or infection. Upon binding to various chemokine receptors including CCR1, CCR2, CCR3, and CCR5, facilitates immune cell migration by guiding them to infected tissues (PubMed:39805173). Interacts with CCR2 to facilitate the release of monocytes from the bone marrow into the bloodstream, maintaining monocyte homeostasis. In turn, monocytes recruited to inflamed or injured tissues can differentiate into macrophages or dendritic cells, which are essential for immune defense and tissue repair (PubMed:17364026). Through CCR1, contributes to macrophage polarization via NF-kappa-B activation which leads to the release of inflammatory factors (PubMed:39805173). In the trigeminal ganglion neurons, activates ERK via CCR2 and CCR3 to enhance neuronal excitability, which contributes to the maintenance of trigeminal neuropathic pain (PubMed:36998150). Additionally, modulates the early immune response in the skin, preventing pathogen dissemination while maintaining cutaneous immune control (PubMed:30671055). {ECO:0000250|UniProtKB:P80098, ECO:0000269|PubMed:17364026, ECO:0000269|PubMed:30671055, ECO:0000269|PubMed:36998150, ECO:0000269|PubMed:39805173}.
uniprot
proteins
mass_dalton
10999
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
10438970
uniprot
proteins
pubmed
1281219
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17364026
uniprot
proteins
pubmed
30671055
uniprot
proteins
pubmed
36998150
uniprot
proteins
pubmed
39805173
uniprot
proteins
pubmed
7989769
uniprot
proteins
pubmed
8002978
uniprot
proteins
pubmed
8455595
uniprot
proteins
sequence_length
97
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins