Adgrb1
entrez
107831
canonical
uniprot
Q3UHD1
canonical
ensembl
ENSMUSG00000034730
resolver
ensp
ENSMUSP00000046097
resolver
ensp
ENSMUSP00000278148
resolver
ensp
ENSMUSP00000278153
resolver
ensp
ENSMUSP00000278164
resolver
enst
ENSMUST00000042035
resolver
genesymbol
Adgrb1
resolver
genesymbol_syn
Bai1
resolver
uniprot
Q3UH36
resolver
uniprot
Q8CGM0
resolver
uniprot_entry
AGRB1_MOUSE
resolver
uniprot_sec
Q3UH36
resolver
uniprot_sec
Q8CGM0
resolver
amino_acid_sequence
MRGQAAAPGPIWILAPLLLLLLLLGRWARAASGADIGPGTEQCTTLVQGKFFGYFSAAAVFPANASRCSWTLRNPDPRRYTLYMKVAKAPAPCSGPGRVRTYQFDSFLESTRTYLGVESFDEVLRLCDSSAPLAFLQASKQFLQMQRQQPPQDGDLGPQGEFPSSSDDFSVEYLVVGNRNPSHAACQMLCRWLDACLAGSRSSHPCGIMQTPCACLGGDVGDPASSPLVPRGDVCLRDGVAGGPENCLTSLTQDRGGHGSAGGWKLWSLWGECTRDCGGGLQTRTRTCLPTLGVEGGGCEGVLEEGRLCNRKACGPTGRSSSRSQSLRSTDARRREEFGDELQQFGFPSPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNWNEWSSWSTCSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCPVDGKWQAWASWGSCSVTCGGGSQRRERVCSGPFFGGAACQGPQDEYRQCGAQRCPEPHEICDEDNFGAVVWKETPAGEVAAVRCPRNATGLILRRCELDEEGIAFWEPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGEGVSEVIQTLLEISQDGTSYSGDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQIISNLLAEENRDKWEEAQLMGPNAKELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASGATDISFPMKGWRATGDWAKVPEDRVTVSKSVFSTGLAEADDSSVFVVGTVLYRNLGSFLALQRNTTVLNSKVISVTVKPPPRSLLTPLEIEFAHMYNGTTNQTCILWDETDGPSSSAPPQLGPWSWRGCRTVPLDALRTRCLCDRLSTFAILAQLSADATMDKVTVPSVTLIVGCGVSSLTLLMLVIIYVSVWRYIRSERSVILINFCLSIISSNALILIGQTQTRNKVVCTLVAAFLHFFFLSSFCWVLTEAWQSYMAVTGRLRSRLVRKRFLCLGWGLPALVVAISVGFTKAKGYSTMNYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKKLKERAGASLWSSCVVLPLLALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCRVVDRQEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSVLNKDIAACRTATITGTFKRPSLPEEEKMKLAKGPPPTFNSLPANVSKLHLHGSPRYPGGPLPDFPNHSLTLKKDKAPKSSFIGDGDIFKKLDSELSRAQEKALDTSYVILPTATATLRPKPKEEPKYSINIDQMPQTRLIHLSMAPDASFPTRSPPAREPPGGAPPEVPPVQPPPPPPPPPPPPQQPIPPPPTLEPAPPSLGDTGEPAAHPGPSSGAGAKNENVATLSVSSLERRKSRYAELDFEKIMHTRKRHQDMFQDLNRKLQHAAEKEKEVPGADSKPEKQQTPNKRAWESLRKPHGTPAWVKKELEPLPPSPLELRSVEWEKAGATIPLVGQDIIDLQTEV
uniprot
proteins
function
FUNCTION: Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:17960134). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:21245295, PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (By similarity). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (By similarity). Promotes myoblast fusion (PubMed:23615608). Activates the Rho pathway in a G protein-dependent manner (By similarity). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (PubMed:25751059). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (By similarity). {ECO:0000250|UniProtKB:C0HL12, ECO:0000250|UniProtKB:O14514, ECO:0000269|PubMed:11875720, ECO:0000269|PubMed:17960134, ECO:0000269|PubMed:21245295, ECO:0000269|PubMed:23615608, ECO:0000269|PubMed:25751059, ECO:0000269|PubMed:26838550}.; FUNCTION: [Vasculostatin-120]: Inhibits angiogenesis in a CD36-dependent manner. {ECO:0000250|UniProtKB:O14514}.; FUNCTION: [Vasculostatin-40]: Inhibits angiogenesis. {ECO:0000250|UniProtKB:O14514}.
uniprot
proteins
mass_dalton
173297
uniprot
proteins
mutagenesis
MUTAGEN 1487..1489; /note="RKR->AAA: Reduced binding to ELMO1 and failure to promote engulfment of apoptotic thymocytes."; /evidence="ECO:0000269|PubMed:17960134
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved to produce vasculostatin-40 and vasculostatin-120. Vasculostatin-40 is the major form and is produced through proteolytic cleavage by MMP14 between residues 321 and 329 with cleavage likely to be between Ser-326 and Leu-327. {ECO:0000250|UniProtKB:O14514}.; PTM: Ubiquitinated. {ECO:0000250|UniProtKB:O14514}.
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
protein_family
LN-TM7 subfamily
uniprot
proteins
pubmed
11245925
uniprot
proteins
pubmed
11875720
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17960134
uniprot
proteins
pubmed
20888903
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21245295
uniprot
proteins
pubmed
23595754
uniprot
proteins
pubmed
23615608
uniprot
proteins
pubmed
23782696
uniprot
proteins
pubmed
25751059
uniprot
proteins
pubmed
26838550
uniprot
proteins
sequence_length
1582
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17960134, ECO:0000269|PubMed:20888903}; Multi-pass membrane protein {ECO:0000255}. Cell projection, phagocytic cup {ECO:0000269|PubMed:17960134}. Cell junction, focal adhesion {ECO:0000269|PubMed:20888903}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:C0HL12}. Postsynaptic density {ECO:0000269|PubMed:23595754, ECO:0000269|PubMed:23782696}.; SUBCELLULAR LOCATION: [Vasculostatin-120]: Secreted {ECO:0000250|UniProtKB:O14514}.; SUBCELLULAR LOCATION: [Vasculostatin-40]: Secreted {ECO:0000250|UniProtKB:O14514}.
uniprot
proteins
transmembrane_region
TRANSMEM 949..969; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 981..1001; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 1009..1029; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 1053..1073; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 1094..1114; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 1137..1157; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 1167..1187; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins