ABI1
entrez
10006
canonical
uniprot
Q8IZP0
canonical
ensembl
ENSG00000136754
resolver
ensp
ENSP00000279599
resolver
ensp
ENSP00000352114
resolver
ensp
ENSP00000365307
resolver
ensp
ENSP00000365308
resolver
ensp
ENSP00000365309
resolver
ensp
ENSP00000365310
resolver
ensp
ENSP00000365312
resolver
ensp
ENSP00000365330
resolver
ensp
ENSP00000365336
resolver
ensp
ENSP00000365340
resolver
ensp
ENSP00000439646
resolver
ensp
ENSP00000440101
resolver
ensp
ENSP00000539288
resolver
ensp
ENSP00000539290
resolver
ensp
ENSP00000539292
resolver
ensp
ENSP00000539294
resolver
ensp
ENSP00000539295
resolver
ensp
ENSP00000539297
resolver
ensp
ENSP00000539306
resolver
ensp
ENSP00000539308
resolver
ensp
ENSP00000539311
resolver
ensp
ENSP00000621468
resolver
ensp
ENSP00000678094
resolver
ensp
ENSP00000694011
resolver
enst
ENST00000376160
resolver
enst
ENST00000536334
resolver
genesymbol
ABI1
resolver
genesymbol_syn
SSH3BP1
resolver
hgnc
HGNC:11320
resolver
uniprot
A0A0A0MRT6
resolver
uniprot
A0ACM8QI39
resolver
uniprot
A9Z1Y6
resolver
uniprot
B3KX62
resolver
uniprot
B4DQ58
resolver
uniprot
B6VEX3
resolver
uniprot
B6VEX4
resolver
uniprot
B6VEX5
resolver
uniprot
F5H1G9
resolver
uniprot
H7BXI6
resolver
uniprot
O15147
resolver
uniprot
O76049
resolver
uniprot
O95060
resolver
uniprot
Q5T2R3
resolver
uniprot
Q5T2R4
resolver
uniprot
Q5T2R6
resolver
uniprot
Q5T2R7
resolver
uniprot
Q5T2R9
resolver
uniprot
Q5W070
resolver
uniprot
Q5W072
resolver
uniprot
Q8TB63
resolver
uniprot
Q96S81
resolver
uniprot
Q9NXZ9
resolver
uniprot
Q9NYB8
resolver
uniprot_entry
A0A0A0MRT6_HUMAN
resolver
uniprot_entry
A0ACM8QI39_HUMAN
resolver
uniprot_entry
ABI1_HUMAN
resolver
uniprot_entry
B6VEX3_HUMAN
resolver
uniprot_entry
B6VEX4_HUMAN
resolver
uniprot_entry
B6VEX5_HUMAN
resolver
uniprot_sec
A9Z1Y6
resolver
uniprot_sec
B3KX62
resolver
uniprot_sec
B4DQ58
resolver
uniprot_sec
F5H1G9
resolver
uniprot_sec
H7BXI6
resolver
uniprot_sec
O15147
resolver
uniprot_sec
O76049
resolver
uniprot_sec
O95060
resolver
uniprot_sec
Q5T2R3
resolver
uniprot_sec
Q5T2R4
resolver
uniprot_sec
Q5T2R6
resolver
uniprot_sec
Q5T2R7
resolver
uniprot_sec
Q5T2R9
resolver
uniprot_sec
Q5W070
resolver
uniprot_sec
Q5W072
resolver
uniprot_sec
Q8TB63
resolver
uniprot_sec
Q96S81
resolver
uniprot_sec
Q9NXZ9
resolver
uniprot_sec
Q9NYB8
resolver
amino_acid_sequence
MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPENISVPPPSGAPPAPPLAPLLPVSTVIAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYTD
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving ABI1 is a cause of acute leukemias. Translocation t(10;11)(p11.2;q23) with KMT2A/MLL1. ABI1 isoform 2 was found to be present in acute leukemia KMT2A/MLL1-ABI1 fusion transcript. {ECO:0000269|PubMed:9694699}.
uniprot
proteins
function
FUNCTION: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}.
uniprot
proteins
mass_dalton
55081
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl. Seems to be phosphorylated at Tyr-53 by ABL1, required for nuclear but not for synaptic localization. {ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:9010225}.
uniprot
proteins
protein_family
ABI family
uniprot
proteins
pubmed
11003655
uniprot
proteins
pubmed
11418237
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12681507
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16417406
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18328268
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19798448
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25121749
uniprot
proteins
pubmed
9010225
uniprot
proteins
pubmed
9593709
uniprot
proteins
pubmed
9694699
uniprot
proteins
sequence_length
508
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Postsynaptic density {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity). {ECO:0000250}.
uniprot
proteins