Stmn2
entrez
20257
canonical
uniprot
P55821
canonical
ensembl
ENSMUSG00000027500
resolver
ensp
ENSMUSP00000029002
resolver
enst
ENSMUST00000029002
resolver
genesymbol
Stmn2
resolver
genesymbol_syn
Scg10
resolver
genesymbol_syn
Scgn10
resolver
genesymbol_syn
Stmb2
resolver
uniprot
Q545S4
resolver
uniprot_entry
Q545S4_MOUSE
resolver
uniprot_entry
STMN2_MOUSE
resolver
amino_acid_sequence
MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG
uniprot
proteins
function
FUNCTION: Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. {ECO:0000269|PubMed:21297631}.
uniprot
proteins
mass_dalton
20828
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000250}.; PTM: Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex. {ECO:0000269|PubMed:16618812}.; PTM: N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Stathmin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16618812
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21297631
uniprot
proteins
pubmed
8288240
uniprot
proteins
sequence_length
179
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16618812}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16618812}. Cell projection, growth cone {ECO:0000269|PubMed:16618812}. Cell projection, axon {ECO:0000269|PubMed:16618812}. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Endosome {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Colocalized with CIB1 in neurites of developing hippocampal primary neurons. Colocalized with CIB1 in the cell body, neuritis, growth cones of neurons and in neurites of developing hippocampal primary neurons. Colocalized with CIB1 to the leading edge of lamellipodia (By similarity). Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. Exists in both soluble and membrane-bound forms. In the developing brain, mostly cytosolic. {ECO:0000250}.
uniprot
proteins