ABHD14B
entrez
84836
canonical
uniprot
Q96IU4
canonical
ensembl
ENSG00000114779
resolver
ensp
ENSP00000354841
resolver
ensp
ENSP00000378455
resolver
genesymbol
ABHD14B
resolver
genesymbol
HEL-S-299
resolver
genesymbol_syn
ABHD14B
resolver
genesymbol_syn
CIB
resolver
hgnc
HGNC:28235
resolver
uniprot
A0A024R352
resolver
uniprot
Q86VK8
resolver
uniprot
Q8N8W5
resolver
uniprot
V9HW87
resolver
uniprot_entry
ABHEB_HUMAN
resolver
uniprot_entry
V9HW87_HUMAN
resolver
uniprot_sec
A0A024R352
resolver
uniprot_sec
Q86VK8
resolver
uniprot_sec
Q8N8W5
resolver
amino_acid_sequence
MAASVEQREGTIQVQGQALFFREALPGSGQARFSVLLLHGIRFSSETWQNLGTLHRLAQAGYRAVAIDLPGLGHSKEAAAPAPIGELAPGSFLAAVVDALELGPPVVISPSLSGMYSLPFLTAPGSQLPGFVPVAPICTDKINAANYASVKTPALIVYGDQDPMGQTSFEHLKQLPNHRVLIMKGAGHPCYLDKPEEWHTGLLDFLQGLQ
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
function
FUNCTION: Acts as an atypical protein-lysine deacetylase in vitro (PubMed:31478652). Catalyzes the deacetylation of lysine residues using CoA as substrate, generating acetyl-CoA and the free amine of protein-lysine residues (PubMed:31478652). Additional experiments are however required to confirm the protein-lysine deacetylase activity in vivo (Probable). Has hydrolase activity towards various surrogate p-nitrophenyl (pNp) substrates, such as pNp-butyrate, pNp-acetate and pNp-octanoate in vitro, with a strong preference for pNp-acetate (PubMed:14672934, PubMed:31478652). May activate transcription (PubMed:14672934). {ECO:0000269|PubMed:14672934, ECO:0000269|PubMed:31478652, ECO:0000305}.
uniprot
proteins
mass_dalton
22346
uniprot
proteins
mutagenesis
MUTAGEN 111; /note="S->A: Abolished protein-lysine deacetylase activity in vitro."; /evidence="ECO:0000269|PubMed:31478652
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
ABHD14 family
uniprot
proteins
pubmed
11053859
uniprot
proteins
pubmed
14672934
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
31478652
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11053859, ECO:0000269|PubMed:14672934, ECO:0000269|PubMed:31478652}. Nucleus {ECO:0000269|PubMed:11053859, ECO:0000269|PubMed:14672934, ECO:0000269|PubMed:31478652}. Note=Predominantly cytoplasmic. {ECO:0000269|PubMed:14672934}.
uniprot
proteins