Ddc
entrez
24311
canonical
uniprot
P14173
canonical
ensembl
ENSRNOG00000004327
resolver
ensp
ENSRNOP00000005851
resolver
ensp
ENSRNOP00000053885
resolver
ensp
ENSRNOP00000082788
resolver
ensp
ENSRNOP00000085523
resolver
enst
ENSRNOT00000057051
resolver
enst
ENSRNOT00000093904
resolver
genesymbol
Ddc
resolver
uniprot
A0A8I5ZZE6
resolver
uniprot
A0A8J8YSU9
resolver
uniprot
A0ACM8QK76
resolver
uniprot
D3ZMA5
resolver
uniprot
F8TLS6
resolver
uniprot
Q6LEG4
resolver
uniprot_entry
A0A8I5ZZE6_RAT
resolver
uniprot_entry
A0ACM8QK76_RAT
resolver
uniprot_entry
D3ZMA5_RAT
resolver
uniprot_entry
DDC_RAT
resolver
uniprot_sec
A0A8J8YSU9
resolver
uniprot_sec
F8TLS6
resolver
uniprot_sec
Q6LEG4
resolver
amino_acid_sequence
MDSREFRRRGKEMVDYIADYLDGIEGRPVYPDVEPGYLRALIPTTAPQEPETYEDIIRDIEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPEAFLAGRAGEGGGVIQGSASEATLVALLAARTKMIRQLQAASPELTQAALMEKLVAYTSDQAHSSVERAGLIGGVKIKAIPSDGNYSMRAAALREALERDKAAGLIPFFVVVTLGTTSCCSFDNLLEVGPICNQEGVWLHIDAAYAGSAFICPEFRYLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTEAFNMDPVYLRHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVKLSHEFESLVRQDPRFEICTEVILGLVCFRLKGSNQLNETLLQRINSAKKIHLVPCRLRDKFVLRFAVCSRTVESAHVQLAWEHIRDLASSVLRAEKE
uniprot
proteins
ec_number
4.1.1.28
uniprot
proteins
function
FUNCTION: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin. {ECO:0000269|PubMed:11358515, ECO:0000269|PubMed:8889823}.
uniprot
proteins
mass_dalton
54053
uniprot
proteins
mutagenesis
MUTAGEN 192; /note="H->A: Abolishes decarboxylase activity."; /evidence="ECO:0000269|PubMed:11358515, ECO:0000269|PubMed:8889823"; MUTAGEN 192; /note="H->Q: Reduces decarboxylase activity by 96%."; /evidence="ECO:0000269|PubMed:11358515, ECO:0000269|PubMed:8889823"; MUTAGEN 252; /note="D->A,E: Abolishes decarboxylase activity."; /evidence="ECO:0000269|PubMed:8889823"; MUTAGEN 271; /note="D->A: Abolishes decarboxylase activity."; /evidence="ECO:0000269|PubMed:11358515, ECO:0000269|PubMed:8889823"; MUTAGEN 271; /note="D->E: Reduces decarboxylase activity by 65%."; /evidence="ECO:0000269|PubMed:11358515, ECO:0000269|PubMed:8889823"; MUTAGEN 296; /note="S->A: Abolishes decarboxylase activity."; /evidence="ECO:0000269|PubMed:8889823"; MUTAGEN 300; /note="N->A: Reduces decarboxylase activity by 75%."; /evidence="ECO:0000269|PubMed:11358515"; MUTAGEN 302; /note="H->Q: Reduces decarboxylase activity by 99.8%."; /evidence="ECO:0000269|PubMed:11358515"; MUTAGEN 303; /note="K->A,R: Abolishes decarboxylase activity."; /evidence="ECO:0000269|PubMed:8889823"; MUTAGEN 332; /note="Y->A,F: Abolishes decarboxylase activity."; /evidence="ECO:0000269|PubMed:8889823"; MUTAGEN 355; /note="R->A: Abolishes decarboxylase activity."; /evidence="ECO:0000269|PubMed:8889823"; MUTAGEN 355; /note="R->K: No effect."; /evidence="ECO:0000269|PubMed:8889823
uniprot
proteins
pathway_participation
PATHWAY: Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2. {ECO:0000269|PubMed:11358515, ECO:0000269|PubMed:8889823}.
uniprot
proteins
protein_family
Group II decarboxylase family
uniprot
proteins
pubmed
11358515
uniprot
proteins
pubmed
1465439
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2813383
uniprot
proteins
pubmed
8889823
uniprot
proteins
sequence_length
480
uniprot
proteins