Krt14
entrez
16664
canonical
uniprot
Q61781
canonical
ensembl
ENSMUSG00000045545
resolver
ensp
ENSMUSP00000007272
resolver
enst
ENSMUST00000007272
resolver
genesymbol
Krt14
resolver
genesymbol_syn
Krt1-14
resolver
uniprot
A2A4G4
resolver
uniprot
Q91VQ4
resolver
uniprot
Q99LE0
resolver
uniprot_entry
K1C14_MOUSE
resolver
uniprot_sec
A2A4G4
resolver
uniprot_sec
Q91VQ4
resolver
uniprot_sec
Q99LE0
resolver
amino_acid_sequence
MATCSRQFTSSSSMKGSCGIGGGSSRMSSILAGGSCRAPSTYGGMSVTSSRFSSGGACGIGGGYGGSFSSSSFGGGLGSGFGGRFDGFGGGFGGGLGGGFGGGLGGGLGGGIGDGLLVGSEKVTMQNLNDRLATYLDKVRALEEANTELEVKIRDWYQRQRPTEIKDYSPYFKTIEDLKSKILAATVDNANVLLQIDNARLAADDFRTKFETEQSLRMSVEADINGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMASMRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFSKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENNLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSSQFSSSSQFSSGSQSSRDVTSTNRQIRTKVMDVHDGKVVSTHEQVLRTKN
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in basal keratinocytes of stratified epithelia. Forms heteropolymers with type II keratin KRT5, contributing to the keratin intermediate filament network that confers mechanical strength and structural integrity to the basal layer of the epidermis and other stratified epithelial. The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro (PubMed:11408584). Displays an antagonist role with KRT15 in basal epithelial cells, where KRT14 promotes cell differentiation while KRT15 maintains the progenitor state and promotes proliferation and clonogenicity (PubMed:36512409, PubMed:41511042). Promotes cell differentiation by retaining YAP1 in the cytoplasm of basal keratinocytes via regulatory residue C373 and SNF interaction (PubMed:32369015, PubMed:41511042). Contributes to airway basal cell differentiation after injury (PubMed:36512409). {ECO:0000269|PubMed:11408584, ECO:0000269|PubMed:32369015, ECO:0000269|PubMed:36512409, ECO:0000269|PubMed:41511042}.
uniprot
proteins
mass_dalton
52867
uniprot
proteins
mutagenesis
MUTAGEN 373; /note="C->A: Decreased disulfide-bonded species. Enhanced keratinocyte proliferation and impaired differentiation. Loss of keratin IFs from the perinuclear region and redistribution towards the cell periphery. Increased YAP nuclear localization."; /evidence="ECO:0000269|PubMed:32369015
uniprot
proteins
post_translational_modification
PTM: A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus. {ECO:0000269|PubMed:22705788}.; PTM: Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex. {ECO:0000250|UniProtKB:P02533}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
11408584
uniprot
proteins
pubmed
12657653
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16702408
uniprot
proteins
pubmed
17227889
uniprot
proteins
pubmed
18285451
uniprot
proteins
pubmed
19267394
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22705788
uniprot
proteins
pubmed
2433272
uniprot
proteins
pubmed
24940650
uniprot
proteins
pubmed
26758872
uniprot
proteins
pubmed
27033150
uniprot
proteins
pubmed
32369015
uniprot
proteins
pubmed
36512409
uniprot
proteins
pubmed
41511042
uniprot
proteins
sequence_length
484
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17227889, ECO:0000269|PubMed:32369015}. Nucleus {ECO:0000269|PubMed:32369015}. Note=Expressed in both as a filamentous pattern. {ECO:0000250|UniProtKB:P02533}.
uniprot
proteins