HHIP
entrez
64399
canonical
uniprot
Q96QV1
canonical
ensembl
ENSG00000164161
resolver
ensp
ENSP00000296575
resolver
genesymbol
HHIP
resolver
genesymbol_syn
HIP
resolver
hgnc
HGNC:14866
resolver
uniprot
Q6PK09
resolver
uniprot
Q8NCI7
resolver
uniprot
Q9BXK3
resolver
uniprot
Q9H1J4
resolver
uniprot
Q9H7E7
resolver
uniprot_entry
HHIP_HUMAN
resolver
uniprot_sec
Q6PK09
resolver
uniprot_sec
Q8NCI7
resolver
uniprot_sec
Q9BXK3
resolver
uniprot_sec
Q9H1J4
resolver
uniprot_sec
Q9H7E7
resolver
amino_acid_sequence
MLKMLSFKLLLLAVALGFFEGDAKFGERNEGSGARRRRCLNGNPPKRLKRRDRRMMSQLELLSGGEMLCGGFYPRLSCCLRSDSPGLGRLENKIFSVTNNTECGKLLEEIKCALCSPHSQSLFHSPEREVLERDLVLPLLCKDYCKEFFYTCRGHIPGFLQTTADEFCFYYARKDGGLCFPDFPRKQVRGPASNYLDQMEEYDKVEEISRKHKHNCFCIQEVVSGLRQPVGALHSGDGSQRLFILEKEGYVKILTPEGEIFKEPYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKLYVSYTTNQERWAIGPHDHILRVVEYTVSRKNPHQVDLRTARVFLEVAELHRKHLGGQLLFGPDGFLYIILGDGMITLDDMEEMDGLSDFTGSVLRLDVDTDMCNVPYSIPRSNPHFNSTNQPPEVFAHGLHDPGRCAVDRHPTDININLTILCSDSNGKNRSSARILQIIKGKDYESEPSLLEFKPFSNGPLVGGFVYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTKQWQEKPLCLGTSGSCRGYFSGHILGFGEDELGEVYILSSSKSMTQTHNGKLYKIVDPKRPLMPEECRATVQPAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQVDRNIRRVTRAGILDQIIDMTSYLLDLTSYIV
uniprot
proteins
function
FUNCTION: Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. {ECO:0000269|PubMed:11472839, ECO:0000269|PubMed:19561609}.
uniprot
proteins
mass_dalton
78851
uniprot
proteins
mutagenesis
MUTAGEN 380; /note="E->A: Abolishes SHH binding."; /evidence="ECO:0000269|PubMed:19561609"; MUTAGEN 382; /note="M->A: Abolishes SHH binding."; /evidence="ECO:0000269|PubMed:19561609"; MUTAGEN 383; /note="D->A,R: Abolishes SHH binding."; /evidence="ECO:0000269|PubMed:19561609, ECO:0000269|PubMed:19561611"; MUTAGEN 387; /note="D->A: Abolishes SHH binding."; /evidence="ECO:0000269|PubMed:19561609
uniprot
proteins
protein_family
HHIP family
uniprot
proteins
pubmed
11435703
uniprot
proteins
pubmed
11472839
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18391950
uniprot
proteins
pubmed
19561609
uniprot
proteins
pubmed
19561611
uniprot
proteins
sequence_length
700
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=The last 22 C-terminal amino acids may participate in cell membrane attachment.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}.
uniprot
proteins