Lgr4
entrez
286994
canonical
uniprot
Q9Z2H4
canonical
ensembl
ENSRNOG00000005715
resolver
ensembl
ENSRNOG00055023472
resolver
ensembl
ENSRNOG00060001759
resolver
ensembl
ENSRNOG00065016106
resolver
ensp
ENSRNOP00000007681
resolver
ensp
ENSRNOP00055032823
resolver
ensp
ENSRNOP00060001787
resolver
ensp
ENSRNOP00065021049
resolver
enst
ENSRNOT00000007681
resolver
enst
ENSRNOT00055040404
resolver
enst
ENSRNOT00060002720
resolver
enst
ENSRNOT00065026804
resolver
genesymbol
Lgr4
resolver
genesymbol_syn
Gpr48
resolver
uniprot
G3V6R1
resolver
uniprot_entry
LGR4_RAT
resolver
uniprot_sec
G3V6R1
resolver
amino_acid_sequence
MPGPLRLLCFFALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKSFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLRTVPSEAIHGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVRPLSNLPTLQALTLALNNISSIPDFAFTNLSSLVVLHLHNNKIKSLSQHCFDGLDNLETLDLNYNNLDEFPQAIKALPSLKELGFHSNSISVIPDGAFGGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASLVQWFPNLTGTVHLESLTLTGTKISSIPDDLCQNQKMLRTLDLSYNNIRDLPSFNGCRALEEISLQRNQISLIKENTFQGLTSLRILDLSRNLIREIHSGAFAKLGTITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKDALAARDFANLRSLSVPYAYQCCAFWGCDSYANLNTEDNSPQEHSVTKEKGATDAANVTSTAENEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALLFNLLVILTVFASCSSLPASKLFIGLISVSNLLMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGSLAVFSSESAVFLLTLAAVERSVFAKDLMKHGKSSHLRQFQVAALLALLGAAVAGCFPLFHGGQYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDLSENSQSSVIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRRVTRKHGSVSVSISSQGGCGEQDFYYDCGMYSHLQGNLTVCDCCESFLLTKPVSCKHLIKSHSCPVLTAASCQRPEAYWSDCGTQSAHSDYADEEDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNLQRVRD
uniprot
proteins
function
FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and pro-inflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP. Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (By similarity). {ECO:0000250|UniProtKB:A2ARI4, ECO:0000250|UniProtKB:Q9BXB1}.
uniprot
proteins
mass_dalton
104241
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
9849958
uniprot
proteins
sequence_length
951
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BXB1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BXB1}.
uniprot
proteins
transmembrane_region
TRANSMEM 545..565; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 576..596; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 620..640; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 662..682; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 704..724; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 757..777; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 784..804; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins