Q9QY76
uniprot
Q9QY76
canonical
amino_acid_sequence
MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTVPRRYCVRPNSGVIDAGASLNVSVMLQPFDYDPNEKSKHKFMVQSMFAPPDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENAKPHDVEINKIIPTSASKTEAPAAAKSLTSPLDDTEVKKVMEECRRLQGEVQRLREESRQLKEEDGLRVRKAMPSNSPVAALAATGKEEGLSARLLALVVLFFIVGVIIGKIAL
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. Interacts with STARD3 in a FFAT motif phosphorylation dependent manner. Via interaction with WDR44 participates in neosynthesized protein export. Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. {ECO:0000250|UniProtKB:O95292}.
uniprot
proteins
mass_dalton
26946
uniprot
proteins
protein_family
VAMP-associated protein (VAP) (TC 9.B.17) family
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24251978
uniprot
proteins
pubmed
41129229
uniprot
proteins
sequence_length
243
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:41129229}; Single-pass type IV membrane protein {ECO:0000255}. Note=Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane. {ECO:0000250|UniProtKB:O95292}.
uniprot
proteins
transmembrane_region
TRANSMEM 219..239; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins