Q91ZR2
uniprot
Q91ZR2
canonical
amino_acid_sequence
MALRARALYDFKSENPGEISLREHEVLSLCSEQDIEGWLEGINSRGDRGLFPASYVQVIRAPEPGPPADGGPGAPARYANVPPGGFEPLPAAPPAAFPPLLQPQASPGSFQPPGAGFPYGGGALQPSPQQLYGGYQASLGSDDDWDDEWDDSSTVADEPGALGSGAYPDLDGSSSAGGGAAGRYRLSTRSDLSLGSRGVSAPPAPSVWSQELGHGEPQPQSLLHLRQVGRGGLRAGRGVRLREGWGQAVRGAGSYGPEWQENPYPFQCTIDDPTKQTKFKGMKSYISYKLVPTHTQVPVHRRYKHFDWLYARLAEKFPVISVPHLPEKQATGRFEEDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTANEFARKQVTGFKKEYQKVGQSFRGLSQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALYQGHLANFPDIIHVQKGALTKVKESRRHVEEGKMEVQKADGIQDRCNTISFATLAEIHHFHQIRVRDFKSQMQHFLQQQIIFFQKVTQKLEEALHKYDSV
uniprot
proteins
function
FUNCTION: Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A. {ECO:0000250|UniProtKB:Q96RF0}.
uniprot
proteins
mass_dalton
67904
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26567222
uniprot
proteins
sequence_length
614
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250|UniProtKB:Q96RF0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96RF0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q96RF0}. Endosome membrane {ECO:0000250|UniProtKB:Q96RF0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96RF0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q96RF0}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q96RF0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96RF0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q96RF0}. Cell membrane {ECO:0000250|UniProtKB:Q96RF0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96RF0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q96RF0}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q96RF0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96RF0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q96RF0}. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized with clathrin and dynamin at the cell membrane. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. {ECO:0000250|UniProtKB:Q96RF0}.
uniprot
proteins