Sycp1
entrez
20957
canonical
uniprot
Q62209
canonical
ensembl
ENSMUSG00000027855
resolver
ensp
ENSMUSP00000029448
resolver
ensp
ENSMUSP00000143651
resolver
enst
ENSMUST00000029448
resolver
enst
ENSMUST00000196988
resolver
genesymbol
Sycp1
resolver
genesymbol_syn
Scp1
resolver
uniprot
B2RQK2
resolver
uniprot
E9QP17
resolver
uniprot
O09205
resolver
uniprot
P70192
resolver
uniprot
Q62329
resolver
uniprot_entry
SYCP1_MOUSE
resolver
uniprot_sec
B2RQK2
resolver
uniprot_sec
E9QP17
resolver
uniprot_sec
O09205
resolver
uniprot_sec
P70192
resolver
uniprot_sec
Q62329
resolver
amino_acid_sequence
MEKQKPFTLFVPPRLSSSQVSAVKPQTAGGDSNYFKTANKCTEGDFGVPFTMSSRENIDKDPAFQKLSILPMLEQVANSGSCHYQEGVNDSDFENSEPMSRLYSKLYKEAEKIKKWKVSIESELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATIHWCNLLKETCARSAEKTNKYEYEREETRQVYVDLNSNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYQKEVNNKENQVSELLIQSAEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELSEKKDHLTSELEDIKMSMQRSMSTQKALEEDLQIATKTISQLTEVKEAQMEELNKAKTTHSFVVTELKATTCTLEELLRTEQQRLEKNEDQLKLITVELQKKSNELEEMTKFKNNKEVELEELKNILAEDQKLLDEKKQVEKLAEELQEKEQELTFLLETREKEVHDLQEQVTVTKTSEQHYLKQVEEMKTELEKEKLKNTELTASCDMLLLENKKFVQEASDMALELKKHQEDIINCKKQEERLLKQIENLEEKEMHLRDELESVRKEFIQQGDEVKCKLDKSEENARSIECEVLKKEKQMKILESKCNNLKKQVENKSKNIEELHQENKTLKKKSSAEIKQLNAYEIKVSKLELELESTKQRFEEMTNNYQKEIENKKISEGKLLGEVEKAKATVDEAVKLQKEIDLRCQHKIAEMVALMEKHKHQYDKIVEERDSELGLYKNREQEQSSAKIALETELSNIRNELVSLKKQLEIEKEEKEKLKMAKENTAILKDKKDKKIQASLLESPEATSWKFDSKTTPSQNISRLSSSMDSGKSKDNRDNLRASAKSILPTTVTKEYTVKTPTKKSIYQRENKYIPTGGSNKKRKTAFEFDVNSDSSETADLLSLVSEEDVSNRLYDNNPPDSHLLVKTPKQTPLSLSTPASFMKFGSLKKMREDRWTTIAKIDRKRRLKEAEKLFS
uniprot
proteins
function
FUNCTION: Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase (PubMed:16717126). Required for normal assembly of the central element of the synaptonemal complexes (PubMed:15937223). Required for normal centromere pairing during meiosis (PubMed:22761579). Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility (PubMed:15937223). {ECO:0000269|PubMed:15937223, ECO:0000269|PubMed:16717126, ECO:0000269|PubMed:22761579}.
uniprot
proteins
mass_dalton
115935
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15937223
uniprot
proteins
pubmed
15944401
uniprot
proteins
pubmed
16717126
uniprot
proteins
pubmed
16968740
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22761579
uniprot
proteins
pubmed
27932493
uniprot
proteins
pubmed
30272023
uniprot
proteins
pubmed
30746471
uniprot
proteins
pubmed
30949703
uniprot
proteins
pubmed
7548215
uniprot
proteins
sequence_length
993
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16717126}. Chromosome {ECO:0000269|PubMed:15937223, ECO:0000269|PubMed:16717126, ECO:0000269|PubMed:16968740, ECO:0000269|PubMed:22761579, ECO:0000269|PubMed:30272023, ECO:0000269|PubMed:30746471, ECO:0000269|PubMed:30949703}. Chromosome, centromere {ECO:0000269|PubMed:22761579}. Note=In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex (By similarity). Only rarely detected at centromeres during leptotene and zygotene. Detected at centromeres during mid-diplotene, when it is no longer present along chromosome arms. No longer detected at centromeres at later stages of meiosis (PubMed:22761579). {ECO:0000250|UniProtKB:Q03410, ECO:0000269|PubMed:22761579}.
uniprot
proteins