Cd2ap
entrez
316258
canonical
uniprot
F1LRS8
canonical
ensembl
ENSRNOG00000011987
resolver
ensembl
ENSRNOG00055020135
resolver
ensembl
ENSRNOG00060022056
resolver
ensembl
ENSRNOG00065025630
resolver
ensp
ENSRNOP00000088324
resolver
ensp
ENSRNOP00000103834
resolver
ensp
ENSRNOP00055027936
resolver
ensp
ENSRNOP00060031945
resolver
ensp
ENSRNOP00065036439
resolver
enst
ENSRNOT00000120136
resolver
enst
ENSRNOT00000142796
resolver
enst
ENSRNOT00055034475
resolver
enst
ENSRNOT00060038690
resolver
enst
ENSRNOT00065044448
resolver
genesymbol
Cd2ap
resolver
uniprot
A0ABK0LRG7
resolver
uniprot
Q7TSS5
resolver
uniprot
Q80ZE7
resolver
uniprot_entry
A0ABK0LRG7_RAT
resolver
uniprot_entry
CD2AP_RAT
resolver
uniprot_entry
Q80ZE7_RAT
resolver
uniprot_sec
Q7TSS5
resolver
amino_acid_sequence
MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEPKDDNLPIKRERPGNVASLVQRISTYGLPAGGIQPHPQTKAMKKKTKKRQCKVLFEYSPQNEDELELTVGDVIDVIEEVEEGWWSGTLNNKLGLFPSNFVKELESTDDGEMHDAQEESEVSLTGPTSPMPSPGNGSEPAPGSVTQPKKIRGVGFGDIFKEGSVKLRTRTSSSETEEKKSEKPLILQSLGSRTQNVEVTKPDIDGKIKAKEYCKTVFPYTGTNEDELTFREGEIIHLISKETGEAGWWKGELNGKEGVFPDNFAVQISELDKDFPKPKKPPPPAKGPAPKPDPLAGEKKTFPLKAEDRDEKSLLEQKPSKPAAPQVPPKKPTPPTKANNLLRSPGTMYPKRPEKPVPPPPPTAKINGEVSTISSKIDTEPLSKPKLDPEQLPVRPKSVDLDALVARNSKETDNVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTQSPEKTLKLPKDDDSGNIKPSEFKKDAGYSSKPSLSAPSSASKVNTAAFLSPLELKAKVEADDGKKSSLDELRAQIIELLCIVDALKKDHGKELEKLRRELEEEKAMRSNLEVEIAKLKKAVLLS
uniprot
proteins
function
FUNCTION: Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (By similarity). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (PubMed:18753381). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. Plays a role in epithelial cell junctions formation (By similarity). {ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000250|UniProtKB:Q9Y5K6, ECO:0000269|PubMed:18753381}.
uniprot
proteins
mass_dalton
70491
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues; probably by c-Abl, Fyn and c-Src. {ECO:0000250}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
18753381
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
637
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9Y5K6}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9Y5K6}. Cell junction {ECO:0000250|UniProtKB:Q9Y5K6}. Note=Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles (By similarity). Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase (By similarity). {ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000250|UniProtKB:Q9Y5K6}.
uniprot
proteins