MBD3
entrez
53615
canonical
uniprot
O95983
canonical
ensembl
ENSG00000071655
resolver
ensp
ENSP00000156825
resolver
ensp
ENSP00000412302
resolver
ensp
ENSP00000601323
resolver
genesymbol
MBD3
resolver
hgnc
HGNC:6918
resolver
uniprot
A8K4B7
resolver
uniprot
D6W5Z2
resolver
uniprot
Q6PIL9
resolver
uniprot
Q6PJZ9
resolver
uniprot
Q86XF4
resolver
uniprot_entry
MBD3_HUMAN
resolver
uniprot_sec
A8K4B7
resolver
uniprot_sec
D6W5Z2
resolver
uniprot_sec
Q6PIL9
resolver
uniprot_sec
Q6PJZ9
resolver
uniprot_sec
Q86XF4
resolver
amino_acid_sequence
MERKRWECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLNAFDIAEELVKTMDLPKGLQGVGPGCTDETLLSAIASALHTSTMPITGQLSAAVEKNPGVWLNTTQPLCKAFMVTDEDIRKQEELVQQVRKRLEEALMADMLAHVEELARDGEAPLDKACAEDDDEEDEEEEEEEPDPDPEMEHV
uniprot
proteins
function
FUNCTION: Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947852, PubMed:18644863). Does not bind to methylated DNA by itself (PubMed:12124384, PubMed:16428440). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12124384, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:18644863, ECO:0000269|PubMed:23361464, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}.
uniprot
proteins
mass_dalton
32844
uniprot
proteins
mutagenesis
MUTAGEN 30; /note="H->K: No effect. Confers strong binding to methylated CpG (in vitro); when associated with Y-34."; /evidence="ECO:0000269|PubMed:12124384, ECO:0000269|PubMed:24307175"; MUTAGEN 34; /note="F->A: Augments DNA binding activity, irrespective of DNA methylation."; /evidence="ECO:0000269|PubMed:12124384, ECO:0000269|PubMed:24307175"; MUTAGEN 34; /note="F->Y: Confers weak binding to methylated CpG (in vitro). Confers strong binding to methylated CpG (in vitro); when associated with K-30."; /evidence="ECO:0000269|PubMed:12124384, ECO:0000269|PubMed:24307175
uniprot
proteins
pubmed
10947852
uniprot
proteins
pubmed
11102443
uniprot
proteins
pubmed
11756549
uniprot
proteins
pubmed
12124384
uniprot
proteins
pubmed
12183469
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15454082
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15701600
uniprot
proteins
pubmed
16428440
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18644863
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20523938
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23361464
uniprot
proteins
pubmed
24307175
uniprot
proteins
pubmed
24385926
uniprot
proteins
pubmed
27732854
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28977666
uniprot
proteins
pubmed
33283408
uniprot
proteins
pubmed
9774669
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15701600, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Chromosome {ECO:0000269|PubMed:27732854}. Note=Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes. {ECO:0000269|PubMed:27732854}.
uniprot
proteins