KRT10
entrez
3858
canonical
uniprot
P13645
canonical
ensembl
ENSG00000186395
resolver
ensp
ENSP00000269576
resolver
ensp
ENSP00000490524
resolver
enst
ENST00000269576
resolver
enst
ENST00000635956
resolver
genesymbol
KRT10
resolver
genesymbol_syn
KPP
resolver
hgnc
HGNC:6413
resolver
uniprot
A0A1B0GVI3
resolver
uniprot
Q14664
resolver
uniprot
Q8N175
resolver
uniprot_entry
A0A1B0GVI3_HUMAN
resolver
uniprot_entry
K1C10_HUMAN
resolver
uniprot_sec
Q14664
resolver
uniprot_sec
Q8N175
resolver
amino_acid_sequence
MSVRYSSSKHYSSSRSGGGGGGGGCGGGGGVSSLRISSSKGSLGGGFSSGGFSGGSFSRGSSGGGCFGGSSGGYGGLGGFGGGSFRGSYGSSSFGGSYGGIFGGGSFGGGSFGGGSFGGGGFGGGGFGGGFGGGFGGDGGLLSGNEKVTMQNLNDRLASYLDKVRALEESNYELEGKIKEWYEKHGNSHQGEPRDYSKYYKTIDDLKNQILNLTTDNANILLQIDNARLAADDFRLKYENEVALRQSVEADINGLRRVLDELTLTKADLEMQIESLTEELAYLKKNHEEEMKDLRNVSTGDVNVEMNAAPGVDLTQLLNNMRSQYEQLAEQNRKDAEAWFNEKSKELTTEIDNNIEQISSYKSEITELRRNVQALEIELQSQLALKQSLEASLAETEGRYCVQLSQIQAQISALEEQLQQIRAETECQNTEYQQLLDIKIRLENEIQTYRSLLEGEGSSGGGGRGGGSFGGGYGGGSSGGGSSGGGHGGGHGGSSGGGYGGGSSGGGSSGGGYGGGSSSGGHGGSSSGGYGGGSSGGGGGGYGGGSSGGGSSSGGGYGGGSSSGGHKSSSSGSVGESSSKGPRY
uniprot
proteins
disease_involvement
DISEASE: Epidermolytic hyperkeratosis 2A (EHK2A) [MIM:620150]: An autosomal dominant form of epidermolytic hyperkeratosis, a skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop. EHK2 inheritance is autosomal dominant or autosomal recessive. {ECO:0000269|PubMed:10201536, ECO:0000269|PubMed:1380725, ECO:0000269|PubMed:1381287, ECO:0000269|PubMed:21271994, ECO:0000269|PubMed:7507150, ECO:0000269|PubMed:7507152, ECO:0000269|PubMed:7508181, ECO:0000269|PubMed:7509230, ECO:0000269|PubMed:7512983, ECO:0000269|PubMed:7526210, ECO:0000269|Ref.7}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Epidermolytic hyperkeratosis 2B, autosomal recessive (EHK2B) [MIM:620707]: An autosomal recessive form of epidermolytic hyperkeratosis, a skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop. {ECO:0000269|PubMed:16505000, ECO:0000269|PubMed:18219278, ECO:0000269|PubMed:19474805, ECO:0000269|PubMed:20302579}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Ichthyosis, annular epidermolytic, 1 (AEI1) [MIM:607602]: A form of annular epidermolytic ichthyosis, an autosomal dominant skin disorder characterized by polycyclic, migratory erythematous and scaly plaques. AEI1 is characterized by the development of widespread erythematous blistering in the neonatal period or early childhood that subsides over time. {ECO:0000269|PubMed:9036939, ECO:0000269|PubMed:9856845}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Ichthyosis with confetti (IWC) [MIM:609165]: An autosomal dominant, rare skin condition characterized by slowly enlarging islands of normal skin surrounded by erythematous ichthyotic patches in a reticulated pattern. The condition starts in infancy as a lamellar ichthyosis, with small islands of normal skin resembling confetti appearing in late childhood and at puberty. Histopathologic findings include band-like parakeratosis, psoriasiform acanthosis, and vacuolization of keratinocytes with binucleated cells in the upper epidermis, sometimes associated with amyloid deposition in the dermis. Ultrastructural abnormalities include perinuclear shells formed from a network of fine filaments in the upper epidermis. {ECO:0000269|PubMed:20798280}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Ichthyosis histrix, Lambert type (IHL) [MIM:146600]: An autosomal dominant form of ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling. IHL is characterized by normal skin at birth that develops striking spiny hyperkeratotic lesions within a few months. There is sparing of the face, palms, and soles, and affected individuals do not experience blistering. {ECO:0000269|PubMed:27212473}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in suprabasal keratinocytes of stratified epithelia. Forms heteropolymers primarily with the type II keratin KRT1, and also with KRT2, assembling into intermediate filament networks that support terminal differentiation, mechanical resilience, and epidermal barrier formation. {ECO:0000269|Ref.7}.; FUNCTION: (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization. {ECO:0000269|PubMed:15385531}.; FUNCTION: (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur. {ECO:0000269|PubMed:19627498}.
uniprot
proteins
mass_dalton
58827
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
10201536
uniprot
proteins
pubmed
12427098
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
1371013
uniprot
proteins
pubmed
1378806
uniprot
proteins
pubmed
1380725
uniprot
proteins
pubmed
1381287
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
15385531
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16505000
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18219278
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19474805
uniprot
proteins
pubmed
19627498
uniprot
proteins
pubmed
20302579
uniprot
proteins
pubmed
20798280
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21271994
uniprot
proteins
pubmed
22719251
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24430336
uniprot
proteins
pubmed
2448602
uniprot
proteins
pubmed
2459124
uniprot
proteins
pubmed
2464696
uniprot
proteins
pubmed
24940650
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27212473
uniprot
proteins
pubmed
27595935
uniprot
proteins
pubmed
32179842
uniprot
proteins
pubmed
7507150
uniprot
proteins
pubmed
7507152
uniprot
proteins
pubmed
7508181
uniprot
proteins
pubmed
7509230
uniprot
proteins
pubmed
7512983
uniprot
proteins
pubmed
7526210
uniprot
proteins
pubmed
9036939
uniprot
proteins
pubmed
9856845
uniprot
proteins
sequence_length
584
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:12427098}. Cell surface {ECO:0000269|PubMed:19627498}. Cytoplasm {ECO:0000269|PubMed:32179842}.
uniprot
proteins