Tbx6
entrez
365371
canonical
uniprot
D3ZJK7
canonical
ensembl
ENSRNOG00000019771
resolver
ensembl
ENSRNOG00055026866
resolver
ensembl
ENSRNOG00060031147
resolver
ensembl
ENSRNOG00065016791
resolver
ensp
ENSRNOP00000060687
resolver
ensp
ENSRNOP00055038059
resolver
ensp
ENSRNOP00060044858
resolver
ensp
ENSRNOP00065022135
resolver
enst
ENSRNOT00000068543
resolver
enst
ENSRNOT00055046397
resolver
enst
ENSRNOT00060054075
resolver
enst
ENSRNOT00065028019
resolver
genesymbol
Tbx6
resolver
uniprot_entry
TBX6_RAT
resolver
amino_acid_sequence
MYHPRELYPSLGTGYRLGHPQPGADSTFPPALTEGYRYPDLDTSKLDCFLSGIEAAPHTLAAPPPLPLLPSALGPETAPPPPEALHSLPGVSLSLENQELWKEFSAVGTEMIITKAGRRMFPACRVSVTGLDPEARYLFLLDVVPVDGARYRWQGQHWEPSGKAEPRLPDRVYIHPDSPATGAHWMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRATQLCSQHWGGVASFRFPETTFISVTAYQNPRITQLKIAANPFAKGFRENGRNCKRERDARVKRKLRGPEPVATEACGSGDTPGGPCDSTLGGDIRDSDPEPAPTPQEAASASAPPCGGPSAEAYLLHPAAFHGAPSHLPARTPSFPEAPDPGRPAPYSAAFLELQPGPGSSAYQTTPSVTPFAPHFIQGAPFPLPYPGPGGYLDMGSKQMY
uniprot
proteins
function
FUNCTION: T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to also play an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
47216
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the complex made of the adapter SMAD6 and the E3 ligase SMURF1, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q13950}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
436
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
uniprot
proteins