GTF2A1
entrez
2957
canonical
uniprot
P52655
canonical
ensembl
ENSG00000165417
resolver
ensp
ENSP00000409492
resolver
ensp
ENSP00000452454
resolver
genesymbol
GTF2A1
resolver
genesymbol_syn
TF2A1
resolver
hgnc
HGNC:4646
resolver
uniprot
Q3KNQ9
resolver
uniprot_entry
TF2AA_HUMAN
resolver
uniprot_sec
Q3KNQ9
resolver
amino_acid_sequence
MANSANTNTVPKLYRSVIEDVINDVRDIFLDDGVDEQVLMELKTLWENKLMQSRAVDGFHSEEQQLLLQVQQQHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIVPDSKLIQHMNASNMSAAATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIFQPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPGGISPQTGVIIQPQQILFTGNKTQVIPTTVAAPTPAQAQITATGQQQPQAQPAQTQAPLVLQVDGTGDTSSEEDEDEEEDYDDDEEEDKEKDGAEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSKAIGDAEW
uniprot
proteins
function
FUNCTION: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. {ECO:0000269|PubMed:11030333, ECO:0000269|PubMed:16537915}.
uniprot
proteins
mass_dalton
41514
uniprot
proteins
mutagenesis
MUTAGEN 270; /note="V->A: Slightly affects cleavage and yields elevated levels of the precursor."; /evidence="ECO:0000269|PubMed:15257296"; MUTAGEN 272; /note="Q->A: Abolishes cleavage."; /evidence="ECO:0000269|PubMed:15257296"; MUTAGEN 273; /note="V->A: Abolishes cleavage."; /evidence="ECO:0000269|PubMed:15257296"; MUTAGEN 274; /note="D->A: Abolishes cleavage."; /evidence="ECO:0000269|PubMed:15257296"; MUTAGEN 275; /note="G->A: Abolishes cleavage."; /evidence="ECO:0000269|PubMed:15257296"; MUTAGEN 276; /note="T->A: Does not affect cleavage."; /evidence="ECO:0000269|PubMed:15257296"; MUTAGEN 277; /note="G->A: Does not affect cleavage."; /evidence="ECO:0000269|PubMed:15257296"; MUTAGEN 278; /note="D->A: Significant reduction of cleavage."; /evidence="ECO:0000269|PubMed:15257296"; MUTAGEN 280; /note="S->A: Slightly affects cleavage, yields elevated levels of the precursor. Eliminates phosphorylation; when associated with A-281; A-316 and A-321."; /evidence="ECO:0000269|PubMed:11278496, ECO:0000269|PubMed:15257296"; MUTAGEN 281; /note="S->A: Eliminates phosphorylation; when associated with A-280; A-316 and A-321."; /evidence="ECO:0000269|PubMed:11278496"; MUTAGEN 282; /note="E->A: Slightly affects cleavage and yields elevated levels of the precursor."; /evidence="ECO:0000269|PubMed:15257296"; MUTAGEN 316; /note="S->A: Strongly reduces phosphorylation; when associated with A-321. Eliminates phosphorylation; when associated with A-280; A-281 and A-321."; /evidence="ECO:0000269|PubMed:11278496"; MUTAGEN 321; /note="S->A: Strongly reduces phosphorylation; when associated with A-316. Eliminates phosphorylation; when associated with A-280; A-281 and A-316."; /evidence="ECO:0000269|PubMed:11278496
uniprot
proteins
post_translational_modification
PTM: The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage promotes proteasomal degradation. {ECO:0000269|PubMed:16537915}.
uniprot
proteins
protein_family
TFIIA subunit 1 family
uniprot
proteins
pubmed
11030333
uniprot
proteins
pubmed
11278496
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15257296
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16537915
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27193682
uniprot
proteins
pubmed
8224848
uniprot
proteins
pubmed
8224850
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins