Ruvbl1
entrez
65137
canonical
uniprot
P60123
canonical
ensembl
ENSRNOG00000013195
resolver
ensembl
ENSRNOG00055011745
resolver
ensembl
ENSRNOG00060026422
resolver
ensembl
ENSRNOG00065015529
resolver
ensp
ENSRNOP00000075190
resolver
ensp
ENSRNOP00055016080
resolver
ensp
ENSRNOP00060037988
resolver
ensp
ENSRNOP00065020267
resolver
enst
ENSRNOT00000090875
resolver
enst
ENSRNOT00055019961
resolver
enst
ENSRNOT00060045782
resolver
enst
ENSRNOT00065025781
resolver
genesymbol
Ruvbl1
resolver
genesymbol_syn
Tip49
resolver
genesymbol_syn
Tip49a
resolver
uniprot
O35753
resolver
uniprot_entry
RUVB1_RAT
resolver
uniprot_sec
O35753
resolver
amino_acid_sequence
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKKMAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAIGLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESLQKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTLHDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGVAELVPGVLFVDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMIIRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKINGKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK
uniprot
proteins
ec_number
3.6.4.12
uniprot
proteins
function
FUNCTION: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (By similarity). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (By similarity). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (By similarity). Essential for cell proliferation (By similarity). May be able to bind plasminogen at cell surface and enhance plasminogen activation (By similarity). {ECO:0000250|UniProtKB:Q9Y265}.
uniprot
proteins
mass_dalton
50214
uniprot
proteins
protein_family
RuvB family
uniprot
proteins
pubmed
10050036
uniprot
proteins
pubmed
10336418
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9196036
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q9Y265}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9Y265}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y265}. Membrane {ECO:0000250|UniProtKB:Q9Y265}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9Y265}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q9DE26}. Note=Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells. {ECO:0000250|UniProtKB:Q9Y265}.
uniprot
proteins