Spop
entrez
20747
canonical
uniprot
Q6ZWS8
canonical
ensembl
ENSMUSG00000057522
resolver
ensp
ENSMUSP00000103350
resolver
ensp
ENSMUSP00000103352
resolver
enst
ENSMUST00000107722
resolver
enst
ENSMUST00000107724
resolver
genesymbol
Spop
resolver
genesymbol_syn
Pcif1
resolver
uniprot
Q3TLC2
resolver
uniprot
Q5ST07
resolver
uniprot
Q76LV9
resolver
uniprot
Q9DBZ2
resolver
uniprot_entry
Q9DBZ2_MOUSE
resolver
uniprot_entry
SPOP_MOUSE
resolver
uniprot_sec
Q3TLC2
resolver
uniprot_sec
Q5ST07
resolver
uniprot_sec
Q76LV9
resolver
amino_acid_sequence
MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS
uniprot
proteins
function
FUNCTION: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL (By similarity). In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability (By similarity). Plays an essential role for proper translation, but not for their degradation, of critical DNA replication licensing factors CDT1 and CDC6, thereby participating in DNA synthesis and cell proliferation. Regulates interferon regulatory factor 1/IRF1 proteasomal turnover by targeting S/T-rich degrons in IRF1 (By similarity). Involved in ubiquitination of BRDT and promotes its degradation, thereby regulates histone removal in early condensing spermatids prior to histone-to-protamine exchange (PubMed:32726616). {ECO:0000250|UniProtKB:O43791, ECO:0000269|PubMed:15121856, ECO:0000269|PubMed:16740475, ECO:0000269|PubMed:20463034, ECO:0000269|PubMed:20811152, ECO:0000269|PubMed:32726616}.
uniprot
proteins
mass_dalton
42132
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
Tdpoz family
uniprot
proteins
pubmed
12183056
uniprot
proteins
pubmed
15121856
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16740475
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20463034
uniprot
proteins
pubmed
20811152
uniprot
proteins
pubmed
32726616
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15121856}. Nucleus speckle {ECO:0000269|PubMed:15121856}.
uniprot
proteins