Lmtk3
entrez
381983
canonical
uniprot
Q5XJV6
canonical
ensembl
ENSMUSG00000062044
resolver
ensp
ENSMUSP00000072388
resolver
ensp
ENSMUSP00000112592
resolver
enst
ENSMUST00000072580
resolver
enst
ENSMUST00000120005
resolver
genesymbol
Lmtk3
resolver
genesymbol_syn
Aatyk3
resolver
uniprot
A0A0R4J0W7
resolver
uniprot
A6BLZ0
resolver
uniprot
Q52KF1
resolver
uniprot_entry
A0A0R4J0W7_MOUSE
resolver
uniprot_entry
LMTK3_MOUSE
resolver
uniprot_sec
A6BLZ0
resolver
uniprot_sec
Q52KF1
resolver
amino_acid_sequence
MPAPGALILLAAVSASGCLASPAHPDGFALSRAPLAPPYAVVLISCSGLLAFIFLLLTCLCCKRGDVRFKEFENPEGEDCSGEYTPPAEETSSSQSLPDVYILPLAEVSLPMPAPQPPHSDISTPLGLSRQHLSYLQEIGSGWFGKVILGEVFSDYSPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGVCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGMSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWVPLRWAAPELLGELHGSFVLVDQSRESNVWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPPSHSAPRPGTLSSQFPLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPPWQPASAPPAPHTNPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPGPQAPQTPSEVPQLVSETWASPLFPAPRPFPAQSSGSGGFLLSGWDPEGRGAGETLAGDPAEVLGEQGTAPWAEEEEEESSPGEDSSSLGGGPSRRGPLPCPLCSREGPCSCLPLERGDAVAGWGDHPALGCPHPPEDDSSLRAERGSLADLPLVPPTSAPLEFLDPLMGAAAPQYPGRGPPPAPPPPPPPPRASAEPAASPDPPSALASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGGAAKEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGSQEKPTFVVQVSTEQLLMSLREDVTKNLLGDKGSTPGETGPRKAGRSPANREKGPGPNRDLTSLVSRKKVPSRSLPVNGVTVLENGKPGVPDMKEKVAENGLESPEKEERALVNGEPMSPEAGEKVLANGVLMSPKSEEKVAENGVLRLPRNTERPPEIGPRRVPGPWEKTPETGGLAPETLLDRAPAPCEAALPQNGLEMAPGQLGPAPKSGNPDPGTEWRVHESGGAPRAPGAGKLDLGSGGRALGGVGTAPAGGPASAVDAKAGWVDNSRPLPPPPQPLGAQQRRPEPVPLKARPEVAQEEEPGVPDNRLGGDMAPSVDEDPLKPERKGPEMPRLFLDLGPPQGNSEQIKAKLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDEDEEDEEAAGSRDPGRTREAPVPVVVSSADGDTVRPLRGLLKSPRAADEPEDSELERKRKMVSFHGDVTVYLFDQETPTNELSVQGTPEGDTEPSTPPAPPTPPHPTTPGDGFPNSDSGFGGSFEWAEDFPLLPPPGPPLCFSRFSVSPALETPGPPARAPDARPAGPVEN
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (By similarity). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (PubMed:24760852). {ECO:0000250|UniProtKB:Q96Q04, ECO:0000269|PubMed:24760852}.
uniprot
proteins
mass_dalton
150891
uniprot
proteins
mutagenesis
MUTAGEN 266; /note="D->V: Significant decrease in autophosphorylation."; /evidence="ECO:0000269|PubMed:17651901
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000269|PubMed:17651901}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17651901
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24760852
uniprot
proteins
sequence_length
1424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:17651901}; Single-pass membrane protein {ECO:0000305|PubMed:17651901}. Cell projection, axon {ECO:0000269|PubMed:17651901}. Cell projection, dendrite {ECO:0000269|PubMed:17651901}. Golgi apparatus membrane {ECO:0000269|PubMed:24760852}. Note=Punctate pattern in cell projections.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins