Ccdc141
entrez
545428
canonical
uniprot
E9Q8Q6
canonical
ensembl
ENSMUSG00000044033
resolver
ensp
ENSMUSP00000128736
resolver
ensp
ENSMUSP00000162547
resolver
ensp
ENSMUSP00000355662
resolver
genesymbol
Ccdc141
resolver
genesymbol_syn
Camdi
resolver
uniprot
A2AST1
resolver
uniprot
Q8BLD3
resolver
uniprot
Q8BUK9
resolver
uniprot_entry
CC141_MOUSE
resolver
uniprot_entry
Q8BLD3_MOUSE
resolver
uniprot_entry
Q8BUK9_MOUSE
resolver
uniprot_sec
A2AST1
resolver
amino_acid_sequence
MSCKESPHVGASTTTVSSVAVHAGDSKIVIAVVKCGKWVRLQLAESQPNLLEIGSSQDETKKLLHDHELLLAKLKALEDRVWELLREADRTAEANKAQSQVYDAMAQTLGEAWATLVSMLERRRELLGLTSEFFQSALEFAIKIDQAEAFLQNPHEFESTEALQSLLLLHDRHAKELLERSLDLLNKSQQLTDFIEKFKCEGSTMNSELIQGAQSSCLKIDSLLELLQDRRRQLDKYLQQQRQELSQVLQLCLWDQQENQVSSWFQKAIRDLQEQSLGASLSDNRELICKHEDLIVKAKEWDSAVEKLKSQALGILLSKDLAGKEHLQLSNQKLNRLQEEFGRLMVERKAWLSMANDFFTSANKSFDVLGKVEAYLKLLKSEGLSLPVLAAKHEELHREIKDSTATALQKGRTLISQVDSCRSRVTGIHEMMGYIQNRVDCLTEQCTAHEEFARKRQQLATSVDDYLRKVEMSIQEIRPILATTLDVASSPSESEKILNKYLELDIQVKETAHALEAAAKIMTEKNELELNEVALLPLKVKWLEEELSTLGRSISCRSRILQTYVAFRKSSEEAEEQLQSLKEFYLTEIPWKDEDDAVVKCQSNSAERKWQLFLKKSFLTQDLSLEFLNLINMAKENEILNVKNEMHIMENIMEKQTNGREELSHLRVAWYLKAIEGKPAREQWEMFKEKLTKTTHSVKLLHEVLMPVSALDLGGSLQSTSDLRRRWIAMKPQLQQLHEDVQQITKEWEVLSSQGAPLKEKAEQLKDLVHLHRRQRERIQEYEEILYKTVQFHQVKEELVHLIKPRELELLAQPMELASSEEVQMQLGRSQERRAHVDHLHQLALTLGVDIISSVQQPNCSNISAKNLQQQLEALELESRSWSAQAKEHERVLSCSLEYCTARDEISELKESFKDIKKKFNNLKFNYSKKNEKSRNLKTLQYQIQQVDTYAEKIQALRKKMEKVNNKTSDSFLSYPSNKANMLSEAMEDLKKNVDDFDKVVTDYKMNLDLTEHLQEVIEECNFWYEDASATVVRVGKYSMECQTREAVDILHRQFNKFITPSVPQQEERIQEVIDLAQRLYGLEEGQKYAEKIVTRHKEILESITELCGSLVELKEKLMQGEVPKMNSDLEDFHDNCIDLLKGPGKDDQKTFSEERNEGQVQGADVLAVNGTREDGLPMDLRRTSSDKEDSAQGLILPEDTLSGEESECISSDDISLPPLPVSPESPLAPSDMEVEELTSSSALALHISGYRMHPGTGGLGKAQESALPSPIAFADGGHSKKDTFTSHFERPYPQLKAESSLASRGSAEMSTKLHINVKCPASMPHEVHDKALQQCSQARESTLEMQEKVHADSNVTKTQDRLHAALDVSPGLGSQPDTSESHQRRVGPQGNKKNSSAENSVVSLAGQAPHFSRLLSNVTVMEGSPVTLEVEVTGFPEPTLTWFKKGQKLCADGHLQVLHKDTKHSVFIPKVCEADAGLYVAQAQNSSGTLSSKAILHVTGNHGPPITRLNWIMLCIIYVSVSVIYWLLTR
uniprot
proteins
function
FUNCTION: Plays a critical role in cortical radial and GnRH neurons migration during brain development (PubMed:20956536, PubMed:27014940). Regulates cortical radial migration by negatively controlling the activity of histone deacetylase 6 (HDAC6) and promotes centrosome maturation (PubMed:27737934). CAMDI is required for dilation formation of cortical neurons during radial migration (PubMed:34298015). Plays a critical role in learning and memory performance through regulation of AMPA-selective glutamate receptors (AMPARs) cell surface expression in competition with KIBRA (PubMed:27014940). {ECO:0000269|PubMed:20956536, ECO:0000269|PubMed:27014940, ECO:0000269|PubMed:27737934, ECO:0000269|PubMed:34298015}.
uniprot
proteins
mass_dalton
173644
uniprot
proteins
mutagenesis
MUTAGEN 91; /note="T->A: Resistance to CDC20-dependent degradation."; /evidence="ECO:0000269|PubMed:34298015"; MUTAGEN 91; /note="T->E: Not resistant to CDC20-dependent degradation."; /evidence="ECO:0000269|PubMed:34298015"; MUTAGEN 123; /note="R->A: Induced abnormal dilation formation. Delayed radial migration with decreases of migration distance and speed. More resistant to degradation during the G2/M phase. Abolishes ubiquitination. Abolishes ubiquitinatination; when associated with 660-A."; /evidence="ECO:0000269|PubMed:34298015"; MUTAGEN 660; /note="R->A: Does not affect ubiqutination. Abolishes ubiquitinatination; when associated with 123-A."; /evidence="ECO:0000269|PubMed:34298015
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated and degradated by the CDC20-APC/C pathway. During brain development, CDC20-APC/C complex degrades CCDC141 after centrosome translocation into the dilated area. CCDC141 is restabilized in the dilation until the centrosome enters the dilation, at which point it is once again immediately destabilized by CDC20-APC/C complex. The oscillatory regulation of CCDC141 protein is needed for proper cortical migration. {ECO:0000269|PubMed:34298015}.; PTM: Phosphorylation at Thr-91 by PLK1 affects CCDC141 degradation. {ECO:0000269|PubMed:34298015}.
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20956536
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27014940
uniprot
proteins
pubmed
27737934
uniprot
proteins
pubmed
31730661
uniprot
proteins
pubmed
34298015
uniprot
proteins
sequence_length
1531
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20956536}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20956536, ECO:0000269|PubMed:34298015}. Note=Co-localized with DISC1 at/around the centrosome. Localizes to the centrosome, at least in part, in a DISC1-dependent manner (PubMed:20956536). Accumulates and oscillates at the dilation in cortical neurons during migration (PubMed:34298015). CAMDI protein level is stabilized at the G1 phase and destabilized at the G2 /M phase (PubMed:34298015). {ECO:0000269|PubMed:20956536, ECO:0000269|PubMed:34298015}.
uniprot
proteins