Acot12
entrez
170570
canonical
uniprot
Q99NB7
canonical
ensembl
ENSRNOG00000061414
resolver
ensp
ENSRNOP00000075534
resolver
genesymbol
Acot12
resolver
genesymbol_syn
Cach
resolver
genesymbol_syn
Cach1
resolver
uniprot_entry
ACO12_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically regulated by ATP (activator) and ADP (inhibitor) (PubMed:11322891). Cold labile, it dissociates into inactive monomers at low temperature (PubMed:6136404). {ECO:0000269|PubMed:11322891, ECO:0000269|PubMed:6136404}.
uniprot
proteins
amino_acid_sequence
MEPTVAPGEVLMSQAIQPAHADSRGELSAGQLLKWMDTTACLAAEKHAGISCVTASMDDILFEDTARIGQIVTIRAKVTRAFSTSMEISIKVRVQDKFTGIQKLLCVAFSTFVVKPLGKEKVHLKPVLLQTEQEQVEHRLASERRKVRLQHENTFSNIMKESNWLRDPVCNEEEGTATTMATSVQSIELVLPPHANHHGNTFGGQIMAWMETVATISASRLCHGHPFLKSVDMFKFRGPSTVGDRLVFNAIVNNTFQNSVEVGVRVEAFDCREWAEGQGRHINSAFLIYNAVDDQEELITFPRIQPISKDDFRRYQGAIARRRIRLGRKYVISHKKEVPLGTQWDISKKGSISNTNVEALKNLASKSGWEITTTLEKIKIYTLEEQDAISVKVEKQVGSPARVAYHLLSDFTKRPLWDPHYISCEVIDQVSEDDQIYYITCSVVNGDKPKDFVVLVSQRKPLKDDNTYIVALMSVVLPSVPPSPQYIRSQVICAGFLIQPVDSSSCTVAYLNQMSDSILPYFAGNIGGWSKSIEEAAASCIKFIENATHDGLKSVL
uniprot
proteins
ec_number
3.1.2.1
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Preferentially hydrolyzes acetyl-CoA. {ECO:0000269|PubMed:11322891}.
uniprot
proteins
mass_dalton
62018
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000305|PubMed:11322891}.
uniprot
proteins
pubmed
11322891
uniprot
proteins
pubmed
6136404
uniprot
proteins
sequence_length
556
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11322891}.
uniprot
proteins