O42043
uniprot
O42043
canonical
amino_acid_sequence
MVTPVTWMDNPIEVYVNDSVWVPGPTDDRCPAKPEEEGMMINISIGYHYPPICLGRAPGCLMPAVQNWLVEVPTVSPNSRFTYHMVSGMSLRPRVNCLQDFSYQRSLKFRPKGKTCPKEIPKGSKNTEVLVWEECVANSVVILQNNEFGTIIDWAPRGQFYHNCSGQTQSCPSAQVSPAVDSDLTESLDKHKHKKLQSFYLWEWEEKGISTPRPKIISPVSGPEHPELWRLTVASHHIRIWSGNQTLETRYRKPFYTIDLNSILTVPLQSCVKPPYMLVVGNIVIKPASQTITCENCRLFTCIDSTFNWQHRILLVRAREGMWIPVSTDRPWEASPSIHILTEILKGVLNRSKRFIFTLIAVIMGLIAVTATAAVAGVALHSSVQSVNFVNYWQKNSTRLWNSQSSIDQKLASQINDLRQTVIWMGDRLMTLEHHFQLQCDWNTSDFCITPQIYNESEHHWDMVRRHLQGREDNLTLDISKLKEQIFEASKAHLNLVPGTEAIAGVADGLANLNPVTWIKTIRSTMIINLILIVVCLFCLLLVCRCTQQLRRDSDIENGP
uniprot
proteins
function
FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This envelope protein has superantigenic properties.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
63671
uniprot
proteins
post_translational_modification
PTM: Specific enzymatic cleavages in vivo yield the mature SU and TM proteins. {ECO:0000250}.
uniprot
proteins
protein_family
Beta type-B retroviral envelope protein family
uniprot
proteins
protein_family
HERV class-II K(HML-2) env subfamily
uniprot
proteins
pubmed
10496080
uniprot
proteins
pubmed
10516026
uniprot
proteins
pubmed
11672540
uniprot
proteins
pubmed
11672541
uniprot
proteins
pubmed
11776384
uniprot
proteins
pubmed
11841850
uniprot
proteins
pubmed
11982593
uniprot
proteins
pubmed
12629516
uniprot
proteins
pubmed
14988274
uniprot
proteins
pubmed
9244304
uniprot
proteins
pubmed
9778243
uniprot
proteins
sequence_length
560
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Surface protein]: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250}.; SUBCELLULAR LOCATION: [Endogenous retrovirus group K member 18 Env polyprotein]: Virion {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 522..542; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins