KIF2C
entrez
11004
canonical
uniprot
Q99661
canonical
ensembl
ENSG00000142945
resolver
ensp
ENSP00000361291
resolver
ensp
ENSP00000361298
resolver
ensp
ENSP00000597068
resolver
genesymbol
KIF2C
resolver
genesymbol_syn
KNSL6
resolver
hgnc
HGNC:6393
resolver
uniprot
A0A140VKF1
resolver
uniprot
B3ITR9
resolver
uniprot
B7Z6Q6
resolver
uniprot
B7Z7M6
resolver
uniprot
E9PDS6
resolver
uniprot
Q5JR88
resolver
uniprot
Q6ICU1
resolver
uniprot
Q96C18
resolver
uniprot
Q96HB8
resolver
uniprot
Q9BWV8
resolver
uniprot_entry
A0A140VKF1_HUMAN
resolver
uniprot_entry
B7Z6Q6_HUMAN
resolver
uniprot_entry
B7Z7M6_HUMAN
resolver
uniprot_entry
KIF2C_HUMAN
resolver
uniprot_sec
B3ITR9
resolver
uniprot_sec
E9PDS6
resolver
uniprot_sec
Q5JR88
resolver
uniprot_sec
Q6ICU1
resolver
uniprot_sec
Q96C18
resolver
uniprot_sec
Q96HB8
resolver
uniprot_sec
Q9BWV8
resolver
amino_acid_sequence
MAMDSSLQARLFPGLAIKIQRSNGLIHSANVRTVNLEKSCVSVEWAEGGATKGKEIDFDDVAAINPELLQLLPLHPKDNLPLQENVTIQKQKRRSVNSKIPAPKESLRSRSTRMSTVSELRITAQENDMEVELPAAANSRKQFSVPPAPTRPSCPAVAEIPLRMVSEEMEEQVHSIRGSSSANPVNSVRRKSCLVKEVEKMKNKREEKKAQNSEMRMKRAQEYDSSFPNWEFARMIKEFRATLECHPLTMTDPIEEHRICVCVRKRPLNKQELAKKEIDVISIPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKAQNASKGIYAMASRDVFLLKNQPCYRKLGLEVYVTFFEIYNGKLFDLLNKKAKLRVLEDGKQQVQVVGLQEHLVNSADDVIKMIDMGSACRTSGQTFANSNSSRSHACFQIILRAKGRMHGKFSLVDLAGNERGADTSSADRQTRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIATISPGISSCEYTLNTLRYADRVKELSPHSGPSGEQLIQMETEEMEACSNGALIPGNLSKEEEELSSQMSSFNEAMTQIRELEEKAMEELKEIIQQGPDWLELSEMTEQPDYDLETFVNKAESALAQQAKHFSALRDVIKALRLAMQLEEQASRQISSKKRPQ
uniprot
proteins
function
FUNCTION: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}.
uniprot
proteins
mass_dalton
81313
uniprot
proteins
mutagenesis
MUTAGEN 95; /note="S->E: Alters interaction with MAPRE1 and association with microtubule growing ends; when associated with E-109 and E-111."; /evidence="ECO:0000269|PubMed:19632184"; MUTAGEN 100..101; /note="IP->NN: Loss of interaction with MAPRE1 and association with microtubule growing ends."; /evidence="ECO:0000269|PubMed:19632184"; MUTAGEN 109; /note="S->E: Alters interaction with MAPRE1 and association with microtubule growing ends; when associated with E-95 and E-111."; /evidence="ECO:0000269|PubMed:19632184"; MUTAGEN 111; /note="S->E: Alters interaction with MAPRE1 and association with microtubule growing ends; when associated with E-95 and E-109."; /evidence="ECO:0000269|PubMed:19632184
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity. {ECO:0000269|PubMed:14960279}.; PTM: Ubiquitinated. {ECO:0000269|PubMed:20596523}.
uniprot
proteins
protein_family
Kinesin family
uniprot
proteins
protein_family
MCAK/KIF2 subfamily
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
11092768
uniprot
proteins
pubmed
12383881
uniprot
proteins
pubmed
14960279
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17485487
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19060894
uniprot
proteins
pubmed
19543227
uniprot
proteins
pubmed
19632184
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20596523
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21820309
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23891108
uniprot
proteins
pubmed
9434124
uniprot
proteins
sequence_length
725
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. Nucleus {ECO:0000250|UniProtKB:P70096}. Chromosome, centromere {ECO:0000269|PubMed:14960279, ECO:0000269|PubMed:17485487}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14960279, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:23891108}. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2. {ECO:0000250|UniProtKB:P70096, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:21820309}.
uniprot
proteins