PDZK1
entrez
5174
canonical
uniprot
Q5T2W1
canonical
ensembl
ENSG00000174827
resolver
ensp
ENSP00000342143
resolver
ensp
ENSP00000394485
resolver
ensp
ENSP00000403422
resolver
ensp
ENSP00000577468
resolver
ensp
ENSP00000630593
resolver
ensp
ENSP00000654004
resolver
ensp
ENSP00000771691
resolver
genesymbol
PDZK1
resolver
genesymbol_syn
CAP70
resolver
genesymbol_syn
NHERF3
resolver
genesymbol_syn
PDZD1
resolver
hgnc
HGNC:8821
resolver
uniprot
B2R7S7
resolver
uniprot
B4DPB9
resolver
uniprot
E7EU02
resolver
uniprot
O60450
resolver
uniprot
Q5T5P6
resolver
uniprot
Q9BQ41
resolver
uniprot_entry
B2R7S7_HUMAN
resolver
uniprot_entry
NHRF3_HUMAN
resolver
uniprot_sec
B4DPB9
resolver
uniprot_sec
E7EU02
resolver
uniprot_sec
O60450
resolver
uniprot_sec
Q5T5P6
resolver
uniprot_sec
Q9BQ41
resolver
amino_acid_sequence
MTSTFNPRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPDTTEEVDHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMAKERAHSTASHSSSNSEDTEM
uniprot
proteins
function
FUNCTION: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
57129
uniprot
proteins
protein_family
NHER family
uniprot
proteins
pubmed
10496535
uniprot
proteins
pubmed
11051556
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15494376
uniprot
proteins
pubmed
15766278
uniprot
proteins
pubmed
16141316
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30604288
uniprot
proteins
pubmed
9461128
uniprot
proteins
sequence_length
519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9JJ40}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JJ40}. Cell membrane {ECO:0000250|UniProtKB:Q9JIL4}. Note=Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes. {ECO:0000250|UniProtKB:Q9JJ40}.
uniprot
proteins