Mast2
entrez
17776
canonical
uniprot
Q60592
canonical
ensembl
ENSMUSG00000003810
resolver
ensp
ENSMUSP00000003908
resolver
ensp
ENSMUSP00000102093
resolver
ensp
ENSMUSP00000159199
resolver
ensp
ENSMUSP00000159270
resolver
ensp
ENSMUSP00000315346
resolver
ensp
ENSMUSP00000315347
resolver
enst
ENSMUST00000003908
resolver
enst
ENSMUST00000106484
resolver
enst
ENSMUST00000239239
resolver
genesymbol
Mast2
resolver
genesymbol_syn
Mast205
resolver
uniprot
A0A668KLF8
resolver
uniprot
B1AST7
resolver
uniprot
B1AST8
resolver
uniprot
E9Q1Q1
resolver
uniprot
E9QLW6
resolver
uniprot
Q6P9M1
resolver
uniprot
Q8CHD1
resolver
uniprot_entry
A0A668KLF8_MOUSE
resolver
uniprot_entry
B1AST7_MOUSE
resolver
uniprot_entry
B1AST8_MOUSE
resolver
uniprot_entry
MAST2_MOUSE
resolver
uniprot_sec
E9Q1Q1
resolver
uniprot_sec
E9QLW6
resolver
uniprot_sec
Q6P9M1
resolver
uniprot_sec
Q8CHD1
resolver
amino_acid_sequence
MVTGLSPLLFRKLSNPDIFAPTGKVKLQRQLSQDDCKLRRGSLASSLSGKQLLPLSSSVHSSVGQVTWQSTGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTENVPDEEGRRSPRMRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERPSLTFISSNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSHYFYELQENLEKLLQDAHERSESSDVAFVIQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGHGIKCDIPRYIVSQLGLTRDPLEEMAQLSSYDSPDTPETDDSVEGRGVSQPSQKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDDALPPDAQDLTSKLLHQNPLERLGTSSAYEVKQHPFFMGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHVDSEDEEEVSEDGCLEIRQFSSCSPRFSKVYSSMERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESSHTESDSSPPMTVRHRCSGLPDGPHCPEETSSTPRKQQQEGIWVLIPPSGEGSSRPVPERPLERQLKLDEEPPGQSSRCCPALETRGRGTPQLAEEATAKAISDLAVRRARHRLLSGDSIEKRTTRPVNKVIKSASATALSLLIPSEHHACSPLASPMSPHSQSSNPSSRDSSPSRDFLPALGSLRPPIIIHRAGKKYGFTLRAIRVYMGDTDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELVLKSGNKVSISTTPLENTSIKVGPARKGSYKAKMARRSKRSKGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPPQGYRVAPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPATAASPQRSPSPLSGHGSQSFPTKLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAAAEKKLAPSRKHSLDLPHGELKKELTPREASPLEVVGTRSVLSGKGPLPGKGVLQPAPSRALGTLRQDRAERRESLQKQEAIREVDSSEDDTDEEPENSQATQEPRLSPHPEASHNLLPKGSGEGTEEDTFLHRDLKKQGPVLSGLVTGATLGSPRVDVPGLSPRKVSRPQAFEEATNPLQVPSLSRSGPTSPTPSEGCWKAQHLHTQALTALCPSFSELTPTGCSAATSTSGKPGTWSWKFLIEGPDRASTNKTITRKGEPANSQDTNTTVPNLLKNLSPEEEKPQPPSVPGLTHPLLEVPSQNWPWESECEQMEKEEPSLSITEVPDSSGDRRQDIPCRAHPLSPETRPSLLWKSQELGGQQDHQDLALTSDELLKQT
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. {ECO:0000269|PubMed:10404183, ECO:0000269|PubMed:14764729, ECO:0000269|PubMed:15308666, ECO:0000269|PubMed:8246979, ECO:0000269|PubMed:8902215}.
uniprot
proteins
mass_dalton
190534
uniprot
proteins
mutagenesis
MUTAGEN 482..483; /note="KK->RA: Abolishes LPS-stimulated IL12B synthesis."; /evidence="ECO:0000269|PubMed:14764729
uniprot
proteins
post_translational_modification
PTM: Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination. {ECO:0000269|PubMed:14764729, ECO:0000269|PubMed:15308666}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10404183
uniprot
proteins
pubmed
14764729
uniprot
proteins
pubmed
15308666
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8246979
uniprot
proteins
pubmed
8902215
uniprot
proteins
sequence_length
1734
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10404183}; Peripheral membrane protein {ECO:0000269|PubMed:10404183}; Cytoplasmic side {ECO:0000269|PubMed:10404183}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10404183}. Cell junction {ECO:0000269|PubMed:10404183}. Note=Colocalizes with beta 2-syntrophin and utrophin at neuromuscular junctions.
uniprot
proteins