Disc1
entrez
307940
canonical
uniprot
Q810H6
canonical
ensembl
ENSRNOG00000019779
resolver
ensp
ENSRNOP00000095161
resolver
genesymbol
Disc1
resolver
uniprot_entry
DISC1_RAT
resolver
amino_acid_sequence
MQGAGSRGAWIHSPSHCPGNGHGSPPAVAPQRRRLTRRPGYMRSTASPGIGFLSPAVGMPRPISAGLTGQEFYPSQSKARQCSLDLRSHCQDSLVGNPFLKGSLGPAVTSVGHLHPAQGSMRERMVHSGVHSGNDRRQSERLTGDSGCRQEFLSSDSSKSLASSLDVAWSKGSRGLKTVRPLVSPASNGPVDIPSLPGFQDTFTSNFSFIRLSLGAAGERGEAEGCLPSREAEPLHQSPQEMAAEGSGSDRPHGEPRHLWTFSLHAAPGLVDLAQGTRSNRQPECGMVSSSDAGFSSQDASPAGGRSDQDGGWADAHGWHALLREWEPMLQDYLLSNRRQLEVTSLILKLQKLQEKAVEDGDYDMAETLRQRLEDLEQEKGRLPWALPSQQPALRSFLGYLATQTHAALHGAPQRAGSDDPEAPLEGQRRTTAQDSLPGLAVTRRDWLMREKEQLQKEIEALRARVSVLEAKEQRLSQELEDQEMLLRWQGCDQMALVAQLSPGQLQEVSKALGETLTSARWAPFRVEPPETLRSLRERTKSLDLAVRELTEQVCSGEKLCSSLRKRLADLDTRLPALLEAKMLALSGSCFSTAKELAEEIWAVSSEREGLEMFLGRLLALSSRNTRRLGSVKEDYLRCRQDLALQEAAHKTRVKANTVKCTEVLEGQLSCCRCPLLERVWKADLEACQLLMQSLEIQEAGSSSHVEDEKQVHSTGEAAQTAALAVPRTPHPEEEKSPLQVLCEWNTYSASLPHCAAGLWKEESHVVFAEVGDKCEAIGMRLLHLEDQLLGAMHGHDEALFQSLQGELQMVKETLQTMFLQLQPAKEAGGEASASYSTAGAQEAED
uniprot
proteins
function
FUNCTION: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:17035248). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (By similarity). {ECO:0000250|UniProtKB:Q811T9, ECO:0000250|UniProtKB:Q9NRI5, ECO:0000269|PubMed:17035248}.
uniprot
proteins
mass_dalton
92563
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination with 'Lys-48'-linked polyubiquitin chains leads to its proteasomal degradation. {ECO:0000250|UniProtKB:Q9NRI5}.
uniprot
proteins
pubmed
12506198
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17035248
uniprot
proteins
pubmed
17389905
uniprot
proteins
sequence_length
846
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12506198}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9NRI5}. Mitochondrion {ECO:0000269|PubMed:12506198}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9NRI5}. Postsynaptic density {ECO:0000250|UniProtKB:Q811T9}. Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria (PubMed:12506198). Colocalizes with PCNT at the centrosome (By similarity). {ECO:0000250|UniProtKB:Q811T9, ECO:0000250|UniProtKB:Q9NRI5, ECO:0000269|PubMed:12506198}.
uniprot
proteins