AGBL5
entrez
60509
canonical
uniprot
Q8NDL9
canonical
ensembl
ENSG00000084693
resolver
ensp
ENSP00000323681
resolver
ensp
ENSP00000353249
resolver
ensp
ENSP00000663445
resolver
ensp
ENSP00000791575
resolver
genesymbol
AGBL5
resolver
genesymbol_syn
CCP5
resolver
hgnc
HGNC:26147
resolver
uniprot
A2VDI7
resolver
uniprot
B7WPG9
resolver
uniprot
B7Z7I7
resolver
uniprot
D6W548
resolver
uniprot
Q53SW0
resolver
uniprot
Q53SZ0
resolver
uniprot
Q96IK8
resolver
uniprot
Q9H6V0
resolver
uniprot
Q9H8P8
resolver
uniprot_entry
CBPC5_HUMAN
resolver
uniprot_sec
A2VDI7
resolver
uniprot_sec
B7WPG9
resolver
uniprot_sec
B7Z7I7
resolver
uniprot_sec
D6W548
resolver
uniprot_sec
Q53SW0
resolver
uniprot_sec
Q53SZ0
resolver
uniprot_sec
Q96IK8
resolver
uniprot_sec
Q9H6V0
resolver
uniprot_sec
Q9H8P8
resolver
amino_acid_sequence
MELRCGGLLFSSRFDSGNLAHVEKVESLSSDGEGVGGGASALTSGIASSPDYEFNVWTRPDCAETEFENGNRSWFYFSVRGGMPGKLIKINIMNMNKQSKLYSQGMAPFVRTLPTRPRWERIRDRPTFEMTETQFVLSFVHRFVEGRGATTFFAFCYPFSYSDCQELLNQLDQRFPENHPTHSSPLDTIYYHRELLCYSLDGLRVDLLTITSCHGLREDREPRLEQLFPDTSTPRPFRFAGKRIFFLSSRVHPGETPSSFVFNGFLDFILRPDDPRAQTLRRLFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLKPDAVLHPAIYGAKAVLLYHHVHSRLNSQSSSEHQPSSCLPPDAPVSDLEKANNLQNEAQCGHSADRHNAEAWKQTEPAEQKLNSVWIMPQQSAGLEESAPDTIPPKESGVAYYVDLHGHASKRGCFMYGNSFSDESTQVENMLYPKLISLNSAHFDFQGCNFSEKNMYARDRRDGQSKEGSGRVAIYKASGIIHSYTLECNYNTGRSVNSIPAACHDNGRASPPPPPAFPSRYTVELFEQVGRAMAIAALDMAECNPWPRIVLSEHSSLTNLRAWMLKHVRNSRGLSSTLNVGVNKKRGLRTPPKSHNGLPVSCSENTLSRARSFSTGTSAGGSSSSQQNSPQMKNSPSFPFHGSRPAGLPGLGSSTQKVTHRVLGPVREPRSQDRRRQQQPLNHRPAGSLAPSPAPTSSGPASSHKLGSCLLPDSFNIPGSSCSLLSSGDKPEAVMVIGKGLLGTGARMPCIKTRLQARPRLGRGSPPTRRGMKGSSGPTSPTPRTRESSELELGSCSATPGLPQARPPRPRSAPAFSPISCSLSDSPSWNCYSRGPLGQPEVCFVPKSPPLTVSPRV
uniprot
proteins
disease_involvement
DISEASE: Retinitis pigmentosa 75 (RP75) [MIM:617023]: A form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP75 inheritance is autosomal recessive. {ECO:0000269|PubMed:26355662, ECO:0000269|PubMed:26720455, ECO:0000269|PubMed:27764769, ECO:0000269|PubMed:27842159}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.17.-
uniprot
proteins
ec_number
3.4.17.24
uniprot
proteins
function
FUNCTION: Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation. {ECO:0000250|UniProtKB:Q09M02}.
uniprot
proteins
mass_dalton
97534
uniprot
proteins
protein_family
Peptidase M14 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23085998
uniprot
proteins
pubmed
26355662
uniprot
proteins
pubmed
26720455
uniprot
proteins
pubmed
27764769
uniprot
proteins
pubmed
27842159
uniprot
proteins
pubmed
39672920
uniprot
proteins
sequence_length
886
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09M02}. Nucleus {ECO:0000269|PubMed:23085998}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23085998}. Midbody {ECO:0000269|PubMed:23085998}. Note=Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis. {ECO:0000250|UniProtKB:Q09M02, ECO:0000269|PubMed:23085998}.
uniprot
proteins