Il4
entrez
287287
canonical
uniprot
P20096
canonical
ensembl
ENSRNOG00000007624
resolver
ensembl
ENSRNOG00055029956
resolver
ensembl
ENSRNOG00060022029
resolver
ensembl
ENSRNOG00065005591
resolver
ensp
ENSRNOP00000010029
resolver
ensp
ENSRNOP00055042861
resolver
ensp
ENSRNOP00060031484
resolver
ensp
ENSRNOP00065005828
resolver
enst
ENSRNOT00000010029
resolver
enst
ENSRNOT00055051924
resolver
enst
ENSRNOT00060038197
resolver
enst
ENSRNOT00065008300
resolver
genesymbol
Il4
resolver
genesymbol_syn
Il-4
resolver
uniprot_entry
IL4_RAT
resolver
amino_acid_sequence
MGLSPHLAVTLFCFLICTGNGIHGCNDSPLREIINTLNQVTEKGTPCTEMFVPDVLTATRNTTENELICRASRVLRKFYFPRDVPPCLKNKSGVLGELRKLCRGVSGLNSLRSCTVNESTLTTLKDFLESLKSILRGKYLQSCTSMS
uniprot
proteins
function
FUNCTION: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. {ECO:0000250|UniProtKB:P07750}.
uniprot
proteins
mass_dalton
16247
uniprot
proteins
protein_family
IL-4/IL-13 family
uniprot
proteins
pubmed
1903705
uniprot
proteins
pubmed
1983334
uniprot
proteins
sequence_length
147
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins