IL10RA
entrez
3587
canonical
uniprot
Q13651
canonical
ensembl
ENSG00000110324
resolver
ensp
ENSP00000227752
resolver
enst
ENST00000227752
resolver
genesymbol
IL10RA
resolver
genesymbol_syn
IL10R
resolver
hgnc
HGNC:5964
resolver
uniprot
A8K6I0
resolver
uniprot
B0YJ27
resolver
uniprot_entry
I10R1_HUMAN
resolver
uniprot_sec
A8K6I0
resolver
uniprot_sec
B0YJ27
resolver
amino_acid_sequence
MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVALLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTNVIIFFAFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLKVSPELKNLDLHGSTDSGFGSTKPSLQTEEPQFLLPDPHPQADRTLGNREPPVLGDSCSSGSSNSTDSGICLQEPSLSPSTGPTWEQQVGSNSRGQDDSGIDLVQNSEGRAGDTQGGSALGHHSPPEPEVPGEEDPAAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLGPKFGRCLVDEAGLHPPALAKGYLKQDPLEMTLASSGAPTGQWNQPTEEWSLLALSSCSDLGISDWSFAHDLAPLGCVAAPGGLLGSFNSDLVTLPLISSLQSSE
uniprot
proteins
disease_involvement
DISEASE: Inflammatory bowel disease 28, autosomal recessive (IBD28) [MIM:613148]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269|PubMed:19890111, ECO:0000269|PubMed:23839161, ECO:0000269|PubMed:24785691}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed:26962683). {ECO:0000269|PubMed:12133952, ECO:0000269|PubMed:16982608, ECO:0000269|PubMed:26962683}.
uniprot
proteins
mass_dalton
63003
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation of the cytoplasmic tail induced STAT3 activation. {ECO:0000250|UniProtKB:Q61727}.; PTM: Ubiquitinated by BTRC; ubiquitination leads to endocytosis and subsequent degradation of IL10RA. {ECO:0000269|PubMed:22087322}.
uniprot
proteins
protein_family
Type II cytokine receptor family
uniprot
proteins
pubmed
11485736
uniprot
proteins
pubmed
12093920
uniprot
proteins
pubmed
12133952
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15837194
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16982608
uniprot
proteins
pubmed
19890111
uniprot
proteins
pubmed
22087322
uniprot
proteins
pubmed
23839161
uniprot
proteins
pubmed
24785691
uniprot
proteins
pubmed
26962683
uniprot
proteins
pubmed
8120391
uniprot
proteins
sequence_length
578
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22087322, ECO:0000269|PubMed:26962683}; Single-pass type I membrane protein. Cytoplasm {ECO:0000269|PubMed:26962683}.
uniprot
proteins
transmembrane_region
TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins