ITM2C
entrez
81618
canonical
uniprot
Q9NQX7
canonical
ensembl
ENSG00000135916
resolver
ensp
ENSP00000322100
resolver
ensp
ENSP00000322730
resolver
ensp
ENSP00000335121
resolver
ensp
ENSP00000387242
resolver
enst
ENST00000409704
resolver
genesymbol
ITM2C
resolver
genesymbol_syn
BRI3
resolver
hgnc
HGNC:6175
resolver
uniprot
B3KPG4
resolver
uniprot
B8ZZM6
resolver
uniprot
Q4G0A8
resolver
uniprot
Q53H84
resolver
uniprot
Q6IAE7
resolver
uniprot
Q86VK5
resolver
uniprot
Q8N288
resolver
uniprot
Q8TAW0
resolver
uniprot
Q9BUP8
resolver
uniprot_entry
B8ZZM6_HUMAN
resolver
uniprot_entry
ITM2C_HUMAN
resolver
uniprot_sec
B3KPG4
resolver
uniprot_sec
Q4G0A8
resolver
uniprot_sec
Q53H84
resolver
uniprot_sec
Q6IAE7
resolver
uniprot_sec
Q86VK5
resolver
uniprot_sec
Q8N288
resolver
uniprot_sec
Q8TAW0
resolver
uniprot_sec
Q9BUP8
resolver
amino_acid_sequence
MVKISFQPAVAGIKGDKADKASASAPAPASATEILLTPAREEQPPQHRSKRGGSVGGVCYLSMGMVVLLMGLVFASVYIYRYFFLAQLARDNFFRCGVLYEDSLSSQVRTQMELEEDVKIYLDENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFWELLMNVKRGTYLPQTYIIQEEMVVTEHVSDKEALGSFIYHLCNGKDTYRLRRRATRRRINKRGAKNCNAIRHFENTFVVETLICGVV
uniprot
proteins
function
FUNCTION: Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18452648, ECO:0000269|PubMed:19366692}.
uniprot
proteins
mass_dalton
30224
uniprot
proteins
mutagenesis
MUTAGEN 241..242; /note="KR->AA: Completely abrogates proteolytic processing."; /evidence="ECO:0000269|PubMed:15606899
uniprot
proteins
post_translational_modification
PTM: Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembrane cleavage by SPPL2B. {ECO:0000269|PubMed:15606899}.
uniprot
proteins
protein_family
ITM2 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11290423
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15606899
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18452648
uniprot
proteins
pubmed
19114711
uniprot
proteins
pubmed
19366692
uniprot
proteins
pubmed
21269460
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:19114711}; Single-pass type II membrane protein {ECO:0000269|PubMed:19114711}.
uniprot
proteins
transmembrane_region
TRANSMEM 55..75; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins