RNF41
entrez
10193
canonical
uniprot
Q9H4P4
canonical
ensembl
ENSG00000181852
resolver
ensp
ENSP00000342755
resolver
ensp
ENSP00000377581
resolver
ensp
ENSP00000447303
resolver
ensp
ENSP00000448187
resolver
ensp
ENSP00000484671
resolver
ensp
ENSP00000672497
resolver
enst
ENST00000552244
resolver
genesymbol
RNF41
resolver
genesymbol_syn
FLRF
resolver
genesymbol_syn
NRDP1
resolver
hgnc
HGNC:18401
resolver
uniprot
A6NFW0
resolver
uniprot
B2RBT8
resolver
uniprot
F8VSB6
resolver
uniprot
O75598
resolver
uniprot_entry
F8VSB6_HUMAN
resolver
uniprot_entry
RNF41_HUMAN
resolver
uniprot_sec
A6NFW0
resolver
uniprot_sec
B2RBT8
resolver
uniprot_sec
O75598
resolver
amino_acid_sequence
MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Also acts as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970). {ECO:0000250, ECO:0000250|UniProtKB:Q8BH75, ECO:0000269|PubMed:12411582, ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15632191, ECO:0000269|PubMed:17210635, ECO:0000269|PubMed:18541373, ECO:0000269|PubMed:19483718, ECO:0000269|PubMed:24949970}.
uniprot
proteins
mass_dalton
35905
uniprot
proteins
mutagenesis
MUTAGEN 34; /note="C->S: Loss of activity; when associated with Q-36."; /evidence="ECO:0000269|PubMed:12411582, ECO:0000269|PubMed:15314180"; MUTAGEN 36; /note="H->Q: Loss of activity; when associated with S-34."; /evidence="ECO:0000269|PubMed:12411582, ECO:0000269|PubMed:15314180"; MUTAGEN 56; /note="D->V: Loss of activity."; /evidence="ECO:0000269|PubMed:12411582
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis. {ECO:0000269|PubMed:15314180, ECO:0000269|PubMed:17210635, ECO:0000269|PubMed:19483718}.
uniprot
proteins
pubmed
12411582
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14765125
uniprot
proteins
pubmed
15314180
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15632191
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17035239
uniprot
proteins
pubmed
17210635
uniprot
proteins
pubmed
18541373
uniprot
proteins
pubmed
19483718
uniprot
proteins
pubmed
24949970
uniprot
proteins
sequence_length
317
uniprot
proteins