Pdp1
entrez
54705
canonical
uniprot
O88483
canonical
ensembl
ENSRNOG00000016180
resolver
ensembl
ENSRNOG00055020786
resolver
ensembl
ENSRNOG00060017427
resolver
ensembl
ENSRNOG00065015436
resolver
ensp
ENSRNOP00000062054
resolver
ensp
ENSRNOP00000069844
resolver
ensp
ENSRNOP00000070525
resolver
ensp
ENSRNOP00000108417
resolver
ensp
ENSRNOP00055028778
resolver
ensp
ENSRNOP00060024054
resolver
ensp
ENSRNOP00065020136
resolver
enst
ENSRNOT00000067823
resolver
enst
ENSRNOT00000090376
resolver
enst
ENSRNOT00000090579
resolver
enst
ENSRNOT00000134828
resolver
enst
ENSRNOT00055035489
resolver
enst
ENSRNOT00060029842
resolver
enst
ENSRNOT00065025628
resolver
genesymbol
Pdp1
resolver
genesymbol_syn
Ppm2c
resolver
uniprot
A0A0G2JWE0
resolver
uniprot
A0A0G2JY56
resolver
uniprot
A0A0G2QC17
resolver
uniprot
A0ABK0LVQ5
resolver
uniprot
A1L1J4
resolver
uniprot
F1LP63
resolver
uniprot_entry
A0A0G2JWE0_RAT
resolver
uniprot_entry
A0A0G2JY56_RAT
resolver
uniprot_entry
A0A0G2QC17_RAT
resolver
uniprot_entry
A0ABK0LVQ5_RAT
resolver
uniprot_entry
PDP1_RAT
resolver
uniprot_sec
A1L1J4
resolver
uniprot_sec
F1LP63
resolver
activity_regulation
ACTIVITY REGULATION: Magnesium-dependent and calcium-stimulated (By similarity). PDP1 activity strongly depends on its Ca(2+)-dependent binding to the lipoyl domain of E2 subunit of component of the pyruvate dehydrogenase complex (By similarity). {ECO:0000250|UniProtKB:P35816, ECO:0000250|UniProtKB:Q9P0J1}.
uniprot
proteins
amino_acid_sequence
MPAPTQLFFPLVRNCELSRIYGTACYCHHKHLCCSPPYIPQNRLRYTPHPAYATFCRPRENWWQYTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESADIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKNEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRAKMSSVFEDQNAATHLIRHAVGNNEFGAVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQEQ
uniprot
proteins
ec_number
3.1.3.43
uniprot
proteins
function
FUNCTION: Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA. {ECO:0000269|PubMed:15210124, ECO:0000269|PubMed:9651365}.
uniprot
proteins
mass_dalton
61180
uniprot
proteins
mutagenesis
MUTAGEN 120; /note="N->A: Decreases protein serine/threonine phosphatase activity."; /evidence="ECO:0000269|PubMed:15210124"; MUTAGEN 125; /note="D->A: Abolishes protein serine/threonine phosphatase activity. Abolishes binding to Mg(2+)."; /evidence="ECO:0000269|PubMed:15210124"; MUTAGEN 418; /note="D->A: Abolishes protein serine/threonine phosphatase activity. Abolishes binding to Mg(2+)."; /evidence="ECO:0000269|PubMed:15210124"; MUTAGEN 516; /note="D->A: Abolishes protein serine/threonine phosphatase activity. Does not affect binding to Mg(2+)."; /evidence="ECO:0000269|PubMed:15210124
uniprot
proteins
protein_family
PP2C family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15210124
uniprot
proteins
pubmed
17532339
uniprot
proteins
pubmed
9651365
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:9651365}.
uniprot
proteins