Sh2d2a
entrez
27371
canonical
uniprot
Q9QXK9
canonical
ensembl
ENSMUSG00000028071
resolver
ensp
ENSMUSP00000029709
resolver
ensp
ENSMUSP00000103207
resolver
genesymbol
Sh2d2a
resolver
genesymbol_syn
Lad
resolver
genesymbol_syn
Ribp
resolver
uniprot
Q5D0E4
resolver
uniprot
Q9JHP6
resolver
uniprot_entry
Q5D0E4_MOUSE
resolver
uniprot_entry
SH22A_MOUSE
resolver
uniprot_sec
Q9JHP6
resolver
amino_acid_sequence
MEFCLAQPCPQGNHEATSSTFNTFQPMNLTQGRCQNLSCGSRPSMQVMKEQGVQLSPRTNHTVVSASAPGTAWVLGNADRAEEVPGKGDLSLQAETRAWVQKTQAHWLLLKTAPLWFHGFITRREAERLLQPQPLGCYLVRFSESAVTFVLSYRSQTCCRHFLLAQLGDGRHVVLGEDSAHAQLQDLLEHYTECPLSPYGEILTQPLARQTAEPAGLSLRADSDSGSKRQDPDTQLSLLLQQGQAQASGHTEKVWASQQKATSQASRPRPPIPAKPQLPPEVYTSPASRLHQAPPINPIYQEPDEPIAFYAMGRGSPGDAPSNIYAEVEGPSGTAPIGHPILRKCWSRPISRGQVREVQGKISSRSRAERGSPS
uniprot
proteins
function
FUNCTION: Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in p56-LCK-mediated T-cell signaling. Could be involved in the regulation of responses to T-cell activation stimuli, specifically proliferation and lymphokine production. Interactions with ITK and TXK may provide important biochemical links of these two important kinases with other components in the T-cell activation machinery. {ECO:0000269|PubMed:10587356}.
uniprot
proteins
mass_dalton
40953
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues upon TCR-stimulation.
uniprot
proteins
pubmed
10553045
uniprot
proteins
pubmed
10587356
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Redistributed from cytoplasm to the plasma membrane in a T-cell activation-dependent manner.
uniprot
proteins