Chst14
entrez
72136
canonical
uniprot
Q80V53
canonical
ensembl
ENSMUSG00000074916
resolver
ensp
ENSMUSP00000099579
resolver
enst
ENSMUST00000099546
resolver
genesymbol
Chst14
resolver
genesymbol_syn
D4st1
resolver
uniprot
A2AQV3
resolver
uniprot
Q3TXA1
resolver
uniprot
Q8R304
resolver
uniprot
Q9D0P2
resolver
uniprot_entry
CHSTE_MOUSE
resolver
uniprot_sec
A2AQV3
resolver
uniprot_sec
Q3TXA1
resolver
uniprot_sec
Q8R304
resolver
uniprot_sec
Q9D0P2
resolver
amino_acid_sequence
MFPRPLTPLAAPKSAETLGRTPRRAPLGRARAGLGGPPLLLPSMLMFAVIVASSGLLLMIERGILSEMKPLPLHPPSHKGAAWSGTDPKPRGLSLDAGDSDLQVREDIRNRTLRAVCGQPGMPRDPWDLPVGQRRTLLRHILVSDRYRFLYCYVPKVACSNWKRVLKVLAGILNNVDVRLKMDHRSDLVFLADLRPEEIRYRLQHYFKFLFVRDPLERLLSAYRNKFGEIREYQQRYGAEIVRRYRAGAGPSPAGDDVTFPEFLRYLVDEDPEHMNEHWMPVYHLCQPCAVHYDFVGSYERLEADANQVLEWVRAPPHVRFPARQAWYRPASPESLHYHLCNVPRALLQDVLPKYILDFSLFAYPLPNVTKEACHQ
uniprot
proteins
ec_number
2.8.2.35
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development. {ECO:0000269|PubMed:16702220}.
uniprot
proteins
mass_dalton
43145
uniprot
proteins
protein_family
Sulfotransferase 2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16702220
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins