Sdr9c7
entrez
70061
canonical
uniprot
Q8K3P0
canonical
ensembl
ENSMUSG00000040127
resolver
ensp
ENSMUSP00000036628
resolver
enst
ENSMUST00000047134
resolver
genesymbol
Sdr9c7
resolver
genesymbol_syn
Rdhs
resolver
genesymbol_syn
Sdro
resolver
uniprot_entry
DR9C7_MOUSE
resolver
amino_acid_sequence
MAALTDFAFMYRWFKNCNLVKNLSEKYVFITGCDSGFGNLLAKQLVDRGMKVLAACLTEEGAQKLLQDTSHQLQTFLLDVTKSENVKEAAQWVRDQVGEQGLWALVNNAGVGLPSGPNEWLTIKDFVKVININLVGLIDVTLNMLPMIKKARGRVVNMSSSGGRVAIFGGGYCVSKFGVEAFSDSIRRELHFFGVKVSIIEPGNYKTSILGQEALESRMKKLWDRLPQETRDSYGEEYFQTYTKKLVNLMRSAEPRISDVTNSMEHAIVSRSPRIRYNPGLDVKFLYLTLAKLPTPVTDFILSRYLPRPADSV
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
function
FUNCTION: Plays a crucial role in the formation of the epidermal permeability barrier. Catalyzes the NAD+-dependent dehydrogenation of the linoleate 9,10-trans-epoxy-11E-13-alcohol esterified in omega-O-acylceramides (such as in N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoyloxy]-acylsphing-4E-enine) to the corresponding 13-ketone, the reactive moiety required for binding of epidermal ceramides to proteins. Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity. {ECO:0000250|UniProtKB:Q8NEX9}.
uniprot
proteins
mass_dalton
35149
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
12234675
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:12234675}.
uniprot
proteins