Cd44
entrez
12505
canonical
uniprot
P15379
canonical
ensembl
ENSMUSG00000005087
resolver
ensp
ENSMUSP00000005218
resolver
ensp
ENSMUSP00000062330
resolver
ensp
ENSMUSP00000097265
resolver
ensp
ENSMUSP00000106821
resolver
ensp
ENSMUSP00000106822
resolver
ensp
ENSMUSP00000106829
resolver
ensp
ENSMUSP00000273704
resolver
enst
ENSMUST00000005218
resolver
enst
ENSMUST00000060516
resolver
enst
ENSMUST00000099673
resolver
enst
ENSMUST00000111190
resolver
enst
ENSMUST00000111191
resolver
enst
ENSMUST00000111198
resolver
genesymbol
Cd44
resolver
genesymbol_syn
Ly-24
resolver
uniprot
A2APM1
resolver
uniprot
A2APM2
resolver
uniprot
A2APM3
resolver
uniprot
A2APM4
resolver
uniprot
F6V225
resolver
uniprot
F7C7R6
resolver
uniprot
Q05732
resolver
uniprot
Q3U8S1
resolver
uniprot
Q61395
resolver
uniprot
Q62060
resolver
uniprot
Q62061
resolver
uniprot
Q62062
resolver
uniprot
Q62063
resolver
uniprot
Q62408
resolver
uniprot
Q62409
resolver
uniprot
Q64296
resolver
uniprot
Q80X37
resolver
uniprot
Q99J14
resolver
uniprot
Q9QYX8
resolver
uniprot_entry
A2APM1_MOUSE
resolver
uniprot_entry
A2APM2_MOUSE
resolver
uniprot_entry
A2APM3_MOUSE
resolver
uniprot_entry
A2APM4_MOUSE
resolver
uniprot_entry
CD44_MOUSE
resolver
uniprot_entry
F6V225_MOUSE
resolver
uniprot_entry
F7C7R6_MOUSE
resolver
uniprot_entry
Q3U8S1_MOUSE
resolver
uniprot_entry
Q80X37_MOUSE
resolver
uniprot_sec
Q05732
resolver
uniprot_sec
Q61395
resolver
uniprot_sec
Q62060
resolver
uniprot_sec
Q62061
resolver
uniprot_sec
Q62062
resolver
uniprot_sec
Q62063
resolver
uniprot_sec
Q62408
resolver
uniprot_sec
Q62409
resolver
uniprot_sec
Q64296
resolver
uniprot_sec
Q99J14
resolver
uniprot_sec
Q9QYX8
resolver
amino_acid_sequence
MDKFWWHTAWGLCLLQLSLAHQQIDLNVTCRYAGVFHVEKNGRYSISRTEAADLCQAFNSTLPTMDQMKLALSKGFETCRYGFIEGNVVIPRIHPNAICAANHTGVYILVTSNTSHYDTYCFNASAPPEEDCTSVTDLPNSFDGPVTITIVNRDGTRYSKKGEYRTHQEDIDASNIIDDDVSSGSTIEKSTPEGYILHTYLPTEQPTGDQDDSFFIRSTLATIASTVHSKSHAAAQKQNNWIWSWFGNSQSTTQTQEPTTSATTALMTTPETPPKRQEAQNWFSWLFQPSESKSHLHTTTKMPGTESNTNPTGWEPNEENEDETDTYPSFSGSGIDDDEDFISSTIATTPRVSARTEDNQDWTQWKPNHSNPEVLLQTTTRMADIDRISTSAHGENWTPEPQPPFNNHEYQDEEETPHATSTTPNSTAEAAATQQETWFQNGWQGKNPPTPSEDSHVTEGTTASAHNNHPSQRITTQSQEDVSWTDFFDPISHPMGQGHQTESKDTDSSHSTTLQPTAAPNTHLVEDLNRTGPLSVTTPQSHSQNFSTLHGEPEEDENYPTTSILPSSTKSSAKDARRGGSLPTDTTTSVEGYTFQYPDTMENGTLFPVTPAKTEVFGETEVTLATDSNVNVDGSLPGDRDSSKDSRGSSRTVTHGSELAGHSSANQDSGVTTTSGPMRRPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINGGNGTVEDRKPSELNGEASKSQEMVHLVNKEPSETPDQCMTADETRNLQSVDMKIGV
uniprot
proteins
function
FUNCTION: Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:25065622, PubMed:8343954). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion. Upon interaction with LGALS9 ligand, activates downstream signaling components including LCK, ERK and MAPK to promotes NK cell activation (PubMed:37006235). {ECO:0000250|UniProtKB:P16070, ECO:0000269|PubMed:25065622, ECO:0000269|PubMed:37006235, ECO:0000269|PubMed:8343954}.
uniprot
proteins
mass_dalton
85617
uniprot
proteins
mutagenesis
MUTAGEN 715..717; /note="KKK->QIN: Loss of interaction with EZR, MSN and RDX and co-localization to microvilli with EZR, MSN and RDX."; /evidence="ECO:0000269|PubMed:9472040
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P16070}.; PTM: O-glycosylated; contains chondroitin sulfate glycans which can be more or less sulfated. {ECO:0000250|UniProtKB:P16070}.; PTM: Phosphorylated; activation of PKC results in the dephosphorylation of Ser-742 (constitutive phosphorylation site), and the phosphorylation of Ser-708. {ECO:0000250}.
uniprot
proteins
pubmed
10859330
uniprot
proteins
pubmed
1469058
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17293874
uniprot
proteins
pubmed
17403031
uniprot
proteins
pubmed
18753140
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19893486
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22510880
uniprot
proteins
pubmed
2403559
uniprot
proteins
pubmed
24606063
uniprot
proteins
pubmed
25065622
uniprot
proteins
pubmed
2681416
uniprot
proteins
pubmed
2682651
uniprot
proteins
pubmed
37006235
uniprot
proteins
pubmed
8343954
uniprot
proteins
pubmed
8464707
uniprot
proteins
pubmed
8509359
uniprot
proteins
pubmed
8702806
uniprot
proteins
pubmed
9472040
uniprot
proteins
sequence_length
778
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17403031, ECO:0000269|PubMed:25065622}; Single-pass type I membrane protein {ECO:0000269|PubMed:17403031}. Cell projection, microvillus {ECO:0000269|PubMed:9472040}. Secreted {ECO:0000250|UniProtKB:P16070}. Note=Colocalizes with actin in membrane protrusionFs at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli. {ECO:0000269|PubMed:17403031, ECO:0000269|PubMed:9472040}.
uniprot
proteins
transmembrane_region
TRANSMEM 686..706; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins