ADAP1
entrez
11033
canonical
uniprot
O75689
canonical
ensembl
ENSG00000105963
resolver
ensp
ENSP00000265846
resolver
ensp
ENSP00000407267
resolver
ensp
ENSP00000442682
resolver
ensp
ENSP00000478011
resolver
ensp
ENSP00000481154
resolver
enst
ENST00000617043
resolver
genesymbol
ADAP1
resolver
genesymbol_syn
CENTA1
resolver
hgnc
HGNC:16486
resolver
uniprot
A0A087WTN6
resolver
uniprot
A4D2Q2
resolver
uniprot
A8K3A2
resolver
uniprot
B3KRZ4
resolver
uniprot
B4DUZ7
resolver
uniprot
B4DVA6
resolver
uniprot
F6XZ68
resolver
uniprot
H7C2Q4
resolver
uniprot_entry
A0A087WTN6_HUMAN
resolver
uniprot_entry
A8K3A2_HUMAN
resolver
uniprot_entry
ADAP1_HUMAN
resolver
uniprot_entry
B4DUZ7_HUMAN
resolver
uniprot_sec
A4D2Q2
resolver
uniprot_sec
B3KRZ4
resolver
uniprot_sec
B4DVA6
resolver
uniprot_sec
F6XZ68
resolver
uniprot_sec
H7C2Q4
resolver
amino_acid_sequence
MAKERRRAVLELLQRPGNARCADCGAPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARARFESKVPSFYYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRNDAKEPKAVMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGAGDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKFLFACETESDQREWVAAFQKAVDRPMLPQEYAVEAHFKHKP
uniprot
proteins
function
FUNCTION: GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Regulates the incorporation of CD63 and CD9 into multivesicular bodies (PubMed:38682696). {ECO:0000269|PubMed:10448098, ECO:0000269|PubMed:38682696, ECO:0000303|PubMed:10333475, ECO:0000305}.
uniprot
proteins
mass_dalton
43395
uniprot
proteins
mutagenesis
MUTAGEN 21; /note="C->A: Loss of GTPase-activating activity."; /evidence="ECO:0000269|PubMed:10333475"; MUTAGEN 24; /note="C->A: Loss of GTPase-activating activity."; /evidence="ECO:0000269|PubMed:10333475"; MUTAGEN 149; /note="R->C: 40-45% reduction in PtdInsP2 3-kinase dependent membrane localization. Almost complete loss of PtdInsP2 3-kinase dependent membrane localization; when associated with C-273."; /evidence="ECO:0000269|PubMed:10333475, ECO:0000269|PubMed:10448098"; MUTAGEN 273; /note="R->C: 70% reduction in PtdInsP2 3-kinase dependent membrane localization. Almost complete loss of PtdInsP2 3-kinase dependent membrane localization; when associated with C-149."; /evidence="ECO:0000269|PubMed:10333475, ECO:0000269|PubMed:10448098
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKCA, PRKCI, PRKCZ and PRKD1 in vitro. {ECO:0000269|PubMed:12893243}.
uniprot
proteins
pubmed
10333475
uniprot
proteins
pubmed
10448098
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12761501
uniprot
proteins
pubmed
12893243
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
38682696
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase.
uniprot
proteins