TAL1
entrez
6886
canonical
uniprot
P17542
canonical
ensembl
ENSG00000162367
resolver
ensp
ENSP00000294339
resolver
ensp
ENSP00000360951
resolver
ensp
ENSP00000510655
resolver
ensp
ENSP00000529879
resolver
ensp
ENSP00000529880
resolver
genesymbol
TAL1
resolver
genesymbol
tal-1
resolver
genesymbol_syn
BHLHA17
resolver
genesymbol_syn
SCL
resolver
genesymbol_syn
TCL5
resolver
hgnc
HGNC:11556
resolver
uniprot
D3DQ24
resolver
uniprot
Q16509
resolver
uniprot_entry
Q16509_HUMAN
resolver
uniprot_entry
TAL1_HUMAN
resolver
uniprot_sec
D3DQ24
resolver
amino_acid_sequence
MTERPPSEAARSDPQLEGRDAAEASMAPPHLVLLNGVAKETSRAAAAEPPVIELGARGGPGGGPAGGGGAARDLKGRDAATAEARHRVPTTELCRPPGPAPAPAPASVTAELPGDGRMVQLSPPALAAPAAPGRALLYSLSQPLASLGSGFFGEPDAFPMFTTNNRVKRRPSPYEMEITDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKLLNDQEEEGTQRAKTGKDPVVGAGGGGGGGGGGAPPDDLLQDVLSPNSSCGSSLDGAASPDSYTEEPAPKHTARSLHPAMLPAADGAGPR
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes. {ECO:0000269|PubMed:2303035}.
uniprot
proteins
function
FUNCTION: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:1396592}.
uniprot
proteins
mass_dalton
34271
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity). {ECO:0000250}.; PTM: Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
1396592
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
2230650
uniprot
proteins
pubmed
2247063
uniprot
proteins
pubmed
2303035
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2602361
uniprot
proteins
pubmed
8437851
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
uniprot
proteins