RUBCNL
entrez
80183
canonical
uniprot
Q9H714
canonical
ensembl
ENSG00000102445
resolver
ensp
ENSP00000368057
resolver
ensp
ENSP00000368061
resolver
ensp
ENSP00000368064
resolver
ensp
ENSP00000368074
resolver
ensp
ENSP00000374558
resolver
ensp
ENSP00000386578
resolver
ensp
ENSP00000396935
resolver
ensp
ENSP00000485932
resolver
ensp
ENSP00000502396
resolver
ensp
ENSP00000523166
resolver
enst
ENST00000378781
resolver
enst
ENST00000378797
resolver
enst
ENST00000409879
resolver
enst
ENST00000675992
resolver
genesymbol
RUBCNL
resolver
genesymbol_syn
C13orf18
resolver
genesymbol_syn
KIAA0226L
resolver
hgnc
HGNC:20420
resolver
uniprot
A0A0A0MRV7
resolver
uniprot
A8KAG9
resolver
uniprot
A8XR19
resolver
uniprot
B3KS87
resolver
uniprot
B7ZBN5
resolver
uniprot
G8JLB1
resolver
uniprot
Q5W051
resolver
uniprot
Q5W053
resolver
uniprot
Q6PJ74
resolver
uniprot
Q6PK94
resolver
uniprot
Q86XH7
resolver
uniprot
Q8N5J6
resolver
uniprot_entry
A0A0A0MRV7_HUMAN
resolver
uniprot_entry
B7ZBN5_HUMAN
resolver
uniprot_entry
PACER_HUMAN
resolver
uniprot_sec
A8KAG9
resolver
uniprot_sec
A8XR19
resolver
uniprot_sec
B3KS87
resolver
uniprot_sec
G8JLB1
resolver
uniprot_sec
Q5W051
resolver
uniprot_sec
Q5W053
resolver
uniprot_sec
Q6PJ74
resolver
uniprot_sec
Q6PK94
resolver
uniprot_sec
Q86XH7
resolver
uniprot_sec
Q8N5J6
resolver
amino_acid_sequence
MVSQSTVRQDSPVEPWEGISDHSGIIDGSPRLLNTDHPPCQLDIRLMRHKAVWINPQDVQQQPQDLQSQVPAAGNSGTHFVTDAASPSGPSPSCLGDSLAETTLSEDTTDSVGSASPHGSSEKSSSFSLSSTEVHMVRPGYSHRVSLPTSPGILATSPYPETDSAFFEPSHLTSAADEGAVQVSRRTISSNSFSPEVFVLPVDVEKENAHFYVADMIISAMEKMKCNILSQQQTESWSKEVSGLLGSDQPDSEMTFDTNIKQESGSSTSSYSGYEGCAVLQVSPVTETRTYHDVKEICKCDVDEFVILELGDFNDITETCSCSCSSSKSVTYEPDFNSAELLAKELYRVFQKCWILSVVNSQLAGSLSAAGSIVVNEECVRKDFESSMNVVQEIKFKSRIRGTEDWAPPRFQIIFNIHPPLKRDLVVAAQNFFCAGCGTPVEPKFVKRLRYCEYLGKYFCDCCHSYAESCIPARILMMWDFKKYYVSNFSKQLLDSIWHQPIFNLLSIGQSLYAKAKELDRVKEIQEQLFHIKKLLKTCRFANSALKEFEQVPGHLTDELHLFSLEDLVRIKKGLLAPLLKDILKASLAHVAGCELCQGKGFICEFCQNTTVIFPFQTATCRRCSACRACFHKQCFQSSECPRCARITARRKLLESVASAAT
uniprot
proteins
function
FUNCTION: Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy (PubMed:28306502, PubMed:30704899). Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (PubMed:28306502). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (PubMed:28306502). Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (PubMed:28306502). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable). {ECO:0000250|UniProtKB:Q3TD16, ECO:0000269|PubMed:28306502, ECO:0000269|PubMed:30704899, ECO:0000305|PubMed:23522960}.
uniprot
proteins
mass_dalton
73457
uniprot
proteins
mutagenesis
MUTAGEN 157; /note="S->A: Abolished phosphorylation by MTOR, leading to promote interaction with STX17 and autophagosome maturation."; /evidence="ECO:0000269|PubMed:30704899"; MUTAGEN 157; /note="S->D: Phosphomimetic mutant; impaired interaction with STX17 and abolished ability to promote autophagosome maturation."; /evidence="ECO:0000269|PubMed:30704899"; MUTAGEN 204..208; /note="VEKEN->AAAAA: Abolishes interaction with UVRAG."; /evidence="ECO:0000269|PubMed:28306502"; MUTAGEN 483; /note="K->R: Abolished acetylation by KAT5/TIP60 and abolished ability to promote autophagosome maturation; when associated with R-523, R-533, R-573 and R-633."; MUTAGEN 523; /note="K->R: Abolished acetylation by KAT5/TIP60 and abolished ability to promote autophagosome maturation; when associated with R-483, R-533, R-573 and R-633."; MUTAGEN 533; /note="K->R: Abolished acetylation by KAT5/TIP60 and abolished ability to promote autophagosome maturation; when associated with R-483, R-523, R-573 and R-633."; MUTAGEN 573; /note="K->R: Abolished acetylation by KAT5/TIP60 and abolished ability to promote autophagosome maturation; when associated with R-483, R-523, R-533 and R-633."; MUTAGEN 633; /note="K->R: Abolished acetylation by KAT5/TIP60 and abolished ability to promote autophagosome maturation; when associated with R-483, R-523, R-533 and R-573.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MTOR at Ser-157 under nutrient-rich conditions (PubMed:30704899). Phosphorylation prevents acetylation by KAT5/TIP60 and impairs RUBCNL/PACER function and autophagosome maturation (PubMed:30704899). Under autophagy induction, Phosphorylation by MTOR is repressed, enabling acetylation by KAT5/TIP60 (PubMed:30704899). {ECO:0000269|PubMed:30704899}.; PTM: Acetylated by KAT5/TIP60 under autophagy induction, promoting autophagosome maturation and lipid metabolism (PubMed:30704899). Acetylation is prevented by phosphorylation by MTOR (PubMed:30704899). Lys-483 and Lys-573 constitute the key sites for tuning function in autophagy (PubMed:30704899). {ECO:0000269|PubMed:30704899}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
23522960
uniprot
proteins
pubmed
28306502
uniprot
proteins
pubmed
30704899
uniprot
proteins
sequence_length
662
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:28306502}; Peripheral membrane protein {ECO:0000269|PubMed:28306502}. Note=Associates with late autophagic structure (PubMed:28306502). Recruitment to autophagosome membrane is promoted by autophagic stimuli (PubMed:28306502). {ECO:0000269|PubMed:28306502}.
uniprot
proteins