Ndfip1
entrez
291609
canonical
uniprot
Q5U2S1
canonical
ensembl
ENSRNOG00000013562
resolver
ensembl
ENSRNOG00055018185
resolver
ensembl
ENSRNOG00060020948
resolver
ensembl
ENSRNOG00065013253
resolver
ensp
ENSRNOP00000093040
resolver
ensp
ENSRNOP00055024830
resolver
ensp
ENSRNOP00060029931
resolver
ensp
ENSRNOP00065016871
resolver
enst
ENSRNOT00000104237
resolver
enst
ENSRNOT00055030842
resolver
enst
ENSRNOT00060036367
resolver
enst
ENSRNOT00065021790
resolver
genesymbol
Ndfip1
resolver
genesymbol_syn
N4wbp5
resolver
uniprot_entry
NFIP1_RAT
resolver
amino_acid_sequence
MALALAALAAVEPACGTGYQQLQNEEEPGEREQTAGDAPPPYSSISAESAAYFDYKDESGFPKPPSYNVATTLPSYDEAERTKAEATIPLVPGRDEDFVGRDDFDDADQLRIGNDGIFMLTFFMAFLFNWIGFFLSFCLTTSAAGRYGAISGFGLSLIKWILIVRFSTYFPGYFDGQYWLWWVFLVLGFLLFLRGFINYAKVRKMPETFSNLPRTRVLFIY
uniprot
proteins
function
FUNCTION: Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation. Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion. Restricts the production of pro-inflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination degradation of RORC. Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination. Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become effector T-cells. Negatively regulates RLR-mediated antiviral response by promoting SMURF1-mediated ubiquitination and subsequent degradation of MAVS. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus where it mediates KCNH2 degradation. In cortical neurons, mediates the ubiquitination of the divalent metal transporter SLC11A2/DMT1 by NEDD4L, leading to its down-regulation and protection of the cells from cobalt and iron toxicity. Important for normal development of dendrites and dendritic spines in cortex. Enhances the ubiquitination of BRAT1 mediated by: NEDD4, NEDD4L and ITCH and is required for the nuclear localization of ubiquitinated BRAT1. Enhances the ITCH-mediated ubiquitination of MAP3K7 by recruiting E2 ubiquitin-conjugating enzyme UBE2L3 to ITCH. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate. Inhibits cell proliferation by promoting PTEN nuclear localization and changing its signaling specificity. {ECO:0000250|UniProtKB:Q8R0W6, ECO:0000250|UniProtKB:Q9BT67}.
uniprot
proteins
mass_dalton
24913
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by NEDD4; mono-, di- and polyubiquitinated forms are detected. Ubiquitination regulates its degradation (By similarity). {ECO:0000250}.; PTM: Undergoes transient tyrosine phosphorylation following EGF stimulation, most probably by catalyzed by SRC. Phosphorylation SRC is enhanced in the presence of NDFIP2 which may act as a scaffold to recruit SRC to NDFIP1 (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23897647
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q9BT67}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BT67}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9BT67}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q8R0W6}. Cell projection, dendrite {ECO:0000269|PubMed:23897647}. Secreted {ECO:0000250|UniProtKB:Q9BT67}. Note=Detected in exosomes and secreted via the exosomal pathway. {ECO:0000250|UniProtKB:Q9BT67}.
uniprot
proteins
transmembrane_region
TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins