SERBP1
entrez
26135
canonical
uniprot
Q8NC51
canonical
ensembl
ENSG00000142864
resolver
ensp
ENSP00000354591
resolver
ensp
ENSP00000360029
resolver
ensp
ENSP00000360033
resolver
ensp
ENSP00000360034
resolver
genesymbol
SERBP1
resolver
genesymbol_syn
PAIRBP1
resolver
hgnc
HGNC:17860
resolver
uniprot
Q5VU19
resolver
uniprot
Q5VU20
resolver
uniprot
Q5VU21
resolver
uniprot
Q5VU22
resolver
uniprot
Q8WUH0
resolver
uniprot
Q96SE2
resolver
uniprot
Q9BTY3
resolver
uniprot
Q9BUM4
resolver
uniprot
Q9Y367
resolver
uniprot
Q9Y4S3
resolver
uniprot_entry
Q5VU21_HUMAN
resolver
uniprot_entry
SERB1_HUMAN
resolver
uniprot_sec
Q5VU19
resolver
uniprot_sec
Q5VU20
resolver
uniprot_sec
Q5VU22
resolver
uniprot_sec
Q8WUH0
resolver
uniprot_sec
Q96SE2
resolver
uniprot_sec
Q9BTY3
resolver
uniprot_sec
Q9BUM4
resolver
uniprot_sec
Q9Y367
resolver
uniprot_sec
Q9Y4S3
resolver
amino_acid_sequence
MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGEGKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMGRGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQKQISYNYSDLDQSNVTEETPEGEEHHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGGRGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA
uniprot
proteins
function
FUNCTION: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}.
uniprot
proteins
mass_dalton
44965
uniprot
proteins
mutagenesis
MUTAGEN 102; /note="K->R: Not sumoylated; when associated with R-228 and R-281."; /evidence="ECO:0000269|PubMed:28695742"; MUTAGEN 228; /note="K->R: Not sumoylated; when associated with R-102 and R-281."; /evidence="ECO:0000269|PubMed:28695742"; MUTAGEN 281; /note="K->R: Not sumoylated; when associated with R-102 and R-228."; /evidence="ECO:0000269|PubMed:28695742
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by MTOR inhibits SERBP1 and relieves ribosome hibernation. {ECO:0000269|PubMed:36691768}.
uniprot
proteins
protein_family
SERBP1-HABP4 family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11001948
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12505151
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18632687
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23636399
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28695742
uniprot
proteins
pubmed
28882895
uniprot
proteins
pubmed
32687489
uniprot
proteins
pubmed
36691768
uniprot
proteins
sequence_length
408
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12505151, ECO:0000269|PubMed:28695742}. Nucleus {ECO:0000269|PubMed:12505151, ECO:0000269|PubMed:28695742}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12505151}.
uniprot
proteins