C7
entrez
109828
canonical
uniprot
D3YXF5
canonical
ensembl
ENSMUSG00000079105
resolver
ensp
ENSMUSP00000106317
resolver
enst
ENSMUST00000110689
resolver
genesymbol
C7
resolver
uniprot_entry
CO7_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Membrane attack complex (MAC) assembly is inhibited by CD59, thereby protecting self-cells from damage during complement activation. MAC assembly is also inhibited by clusterin (CLU) chaperones that inhibit polymerization of C9. {ECO:0000250|UniProtKB:P10643}.
uniprot
proteins
amino_acid_sequence
MQVTSLLILVCFIAAFQVFSRASSPVNCKWDSYGPWSECNGCTKTQTRRRSVAVYGQYGGYPCEGSAFETQSCKPERGCPTEEGCGDRFRCFSGQCISKSLVCNGDPDCEEDGADEDKCENVANPSCNIDKPPPNIELTGYGYNVVTGQGKKRVINTKSFGGQCRKVFSGDGKDFYRLSGNILSYTFQVKVDNDFNYEFYNSSWSYIKHTSTEQNTFYSWKGLFSHSRNTYGHGSAKEEIDTKMKSYKLLVVQNTVEVAQFTNNNPEFLQVAEPFWKELSHLPTLYDYSAYRRLIDQYGTHYLQSGSLGGEYRVLFYVDSGSAKETGFQSDQDNACSSADFQFLFTSSADQRCMKQLETEKSTSGNKGRLLRGKPLVRGGDSGFVADLSFLDLDNPAGNKQRYSSWAGSVTRLPQVIKEKLAPLYELVKEVPCASVKRLYLKRAIEEYFDEFDPCHCRPCQNGGLAIVVETQCQCLCKPYTFGSACEQGVLVGDQAGGVDGGWNCWSSWSPCVQGKRTRSRECNNPPPRDDGKSCLGETTESKQCEDQDLEKLRLLEPHCFHSSLAPKEFCLSPPALKDGFVQGEGTMVPVGQSVVYACDEGYSLIGDPVARCGEDLQWLVGEMHCQKLACVLPGEMNGMQSHPQKPFYMVGEKVTLSCVGGMSLEGPSTLLCGSSLKWSPELKDAKCVQKATSTPPPAAPACQPWEKLQNSKCICKMPYECGSSLDVCARDESRNKILSLTICKMHVVHCHKRNYTLVGKESCTLPSPAEKVCGACPIWSKCDAQNGKCICREASECQTAGYRICVEVNGKEETMSECEAGILRCRGQSISITAIKPCAEEAAQ
uniprot
proteins
function
FUNCTION: Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C7 serves as a membrane anchor. During MAC assembly, associates with C5b and C6 to form the C5b-7 complex, a key lipophilic precursor of the MAC complex, which associates with the outer leaflet and reduces the energy for membrane bending. {ECO:0000250|UniProtKB:P10643}.
uniprot
proteins
mass_dalton
93337
uniprot
proteins
post_translational_modification
PTM: C-, N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. {ECO:0000250|UniProtKB:P10643}.
uniprot
proteins
protein_family
Complement C6/C7/C8/C9 family
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
845
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P10643}. Target cell membrane {ECO:0000250|UniProtKB:P10643}. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells. {ECO:0000250|UniProtKB:P10643}.
uniprot
proteins