Top1mt
entrez
300029
canonical
uniprot
Q6IM78
canonical
ensembl
ENSRNOG00000007500
resolver
ensembl
ENSRNOG00055025377
resolver
ensembl
ENSRNOG00060019253
resolver
ensembl
ENSRNOG00065009714
resolver
ensp
ENSRNOP00000070025
resolver
ensp
ENSRNOP00000105400
resolver
ensp
ENSRNOP00055035882
resolver
ensp
ENSRNOP00060027630
resolver
ensp
ENSRNOP00065011805
resolver
enst
ENSRNOT00055043898
resolver
enst
ENSRNOT00060033739
resolver
enst
ENSRNOT00065015636
resolver
genesymbol
Top1mt
resolver
uniprot_entry
TOP1M_RAT
resolver
amino_acid_sequence
MLLLWLRALCRRFQHVPRRVPSRQVSRGSKASRAGWGETSKSSVKWKQLEHKGPCFAPAYEPLPDGVRFFYDGKPVRLSLAAEEVATFYGKMLHLECTTKEVFRRNFFSDWQKEMTAEERKLITHLDKCDFSEIHRHFMERAEARRTLPREQKQKLKEEAEKLQQEFGYCILDGHREKIGNFKTEPPGLFRGRGDHPKMGMLKRRVMPEDVVINCSRDSKIPEPPAGHQWKEVRSDNTVMWLAAWVENIQNSFKYIILNPSSKPKGEMDWQKYEVARRLKGVVDKIRAQYQADWKSPEMKKRQLAVALYFIDKLALRTGNEKEEGETADTVGCCSLRVEHVRLHTPADGQEHVVELDFLGKDSIRYKNHVTVEKLVFQNLQHFMEDKDPRDDLFDALTTSSLNKHLQDLMEGLTAKVFRTYNASITLQEQLRVLTRAEDSLTCKVLAYNRANRAVAVLCNHQRAIPKTFEESMQTLQKKIETKKAQVAEAQVELQKAETDLRMRGDSKSKSFLQKQQRLLKLEEQLARLCTKATDKEENKQVALGTAKLNYLDPRISIAWCKRFGVPVEKIYNKTQRERFAWAFNQAGEDFEF
uniprot
proteins
ec_number
5.6.2.1
uniprot
proteins
function
FUNCTION: Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
69011
uniprot
proteins
protein_family
Type IB topoisomerase family
uniprot
proteins
pubmed
15096574
uniprot
proteins
sequence_length
593
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
uniprot
proteins