Slc17a5
entrez
363103
canonical
uniprot
Q5Q0U0
canonical
ensembl
ENSRNOG00000090360
resolver
ensembl
ENSRNOG00055004787
resolver
ensembl
ENSRNOG00060021295
resolver
ensembl
ENSRNOG00065015882
resolver
ensp
ENSRNOP00000098782
resolver
ensp
ENSRNOP00000111035
resolver
ensp
ENSRNOP00055005741
resolver
ensp
ENSRNOP00060030377
resolver
ensp
ENSRNOP00065020693
resolver
enst
ENSRNOT00000122421
resolver
enst
ENSRNOT00000141108
resolver
enst
ENSRNOT00055007622
resolver
enst
ENSRNOT00060036867
resolver
enst
ENSRNOT00065026385
resolver
genesymbol
Slc17a5
resolver
uniprot
A0ABK0M056
resolver
uniprot_entry
A0ABK0M056_RAT
resolver
uniprot_entry
S17A5_RAT
resolver
amino_acid_sequence
MRPLLRGPAGNDDEESSDSTPLLPSARQIEAAPACCSARYNLALLAFCGFFVLYALRVNLSVALVDMVDSNSTLTDNRTSKECAEHSAPVKVHHNHTGKKYQWDAETQGWILGSFFYGYIVTQIPGGYMASRIGGKLLLGLGILGTAVFTLFTPLAADLGVVALIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGLVGIVWFILWMWIVSDTPETHKTISHYEKEYIVSSLKNQLSSQKVVPWVSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMIVCGQAADYLRVKWNFSTISVRRIFSLIGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPIIAKSLTPDNTIKEWQTVFCIAAAINVFGAIFFTLFAKGEVQNWALSDHHGHGN
uniprot
proteins
function
FUNCTION: Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport (By similarity). Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system (By similarity) (PubMed:15516337, PubMed:20424173). Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1. May contribute to nitrate clearance from serum by salivary glands, where it is further concentrated and secreted in the saliva (By similarity). Uses membrane potential to drive the uptake of acidic amino acids and peptides into synaptic vesicles. Responsible for synaptic vesicular storage of L-aspartate and L-glutamate in pinealocytes as well as vesicular uptake of N-acetyl-L-aspartyl-L-glutamate neuropeptide, relevant to aspartegic-associated glutamatergic neurotransmission and activation of metabotropic receptors that inhibit subsequent transmitter release (By similarity). {ECO:0000250|UniProtKB:Q8BN82, ECO:0000250|UniProtKB:Q9NRA2, ECO:0000269|PubMed:15516337, ECO:0000269|PubMed:20424173}.; FUNCTION: Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties. {ECO:0000250|UniProtKB:Q9MZD1}.
uniprot
proteins
mass_dalton
54323
uniprot
proteins
mutagenesis
MUTAGEN 22..23; /note="LL->AA: Targeted to plasma membrane; sialic acid uptake strongly activated at acidic pH."; /evidence="ECO:0000269|PubMed:15516337"; MUTAGEN 39; /note="R->C: Markedly decreases H(+)-coupled sialic acid transporter activity."; /evidence="ECO:0000269|PubMed:15516337"; MUTAGEN 136; /note="K->E: Markedly decreases H(+)-coupled sialic acid transporter activity."; /evidence="ECO:0000269|PubMed:15516337"; MUTAGEN 168; /note="R->C: Abolishes H(+)-coupled sialic acid transporter activity."; /evidence="ECO:0000269|PubMed:20424173"; MUTAGEN 171; /note="E->C: Decreases H(+)-coupled sialic acid transporter activity; when associated with C-175."; /evidence="ECO:0000269|PubMed:20424173"; MUTAGEN 172; /note="G->C: Decreases protein levels and alters subcellular localization."; /evidence="ECO:0000269|PubMed:20424173"; MUTAGEN 175; /note="E->C: Decreases H(+)-coupled sialic acid transporter activity; when associated with C-171."; /evidence="ECO:0000269|PubMed:20424173"; MUTAGEN 176; /note="G->C: Decreases protein levels and alters subcellular localization."; /evidence="ECO:0000269|PubMed:20424173"; MUTAGEN 179; /note="F->C: Decreases the affinity and transport rate for D-glucuronate. Does not affect H(+)-coupled sialic acid transporter activity."; /evidence="ECO:0000269|PubMed:20424173"; MUTAGEN 180; /note="P->C: Decreases protein levels and alters subcellular localization."; /evidence="ECO:0000269|PubMed:20424173"; MUTAGEN 183; /note="H->R: Abolishes H(+)-coupled sialic acid transporter activity."; /evidence="ECO:0000269|PubMed:15516337"; MUTAGEN 186; /note="W->C: Abolishes H(+)-coupled sialic acid transporter activity."; /evidence="ECO:0000269|PubMed:20424173"; MUTAGEN 268..272; /note="Missing: Abolishes H(+)-coupled sialic acid transporter activity."; /evidence="ECO:0000269|PubMed:15516337"; MUTAGEN 334; /note="P->R: Abolishes H(+)-coupled sialic acid transporter activity."; /evidence="ECO:0000269|PubMed:15516337"; MUTAGEN 371; /note="G->V: Remains in the endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:15516337
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15516337
uniprot
proteins
pubmed
20424173
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
495
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:Q9NRA2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NRA2}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9NRA2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NRA2}. Lysosome membrane {ECO:0000250|UniProtKB:Q9NRA2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NRA2}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..65; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 137..157; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 163..186; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 198..220; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 226..247; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 291..312; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 332..354; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 366..385; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 391..412; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 424..444; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 456..478; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins