Cracr2a
entrez
381812
canonical
uniprot
Q3UP38
canonical
ensembl
ENSMUSG00000061414
resolver
ensp
ENSMUSP00000071494
resolver
ensp
ENSMUSP00000148569
resolver
ensp
ENSMUSP00000304582
resolver
genesymbol
Cracr2a
resolver
genesymbol_syn
Efcab4b
resolver
genesymbol_syn
Gm1073
resolver
genesymbol_syn
Rab46
resolver
uniprot
A0A1D5RLZ8
resolver
uniprot
B9EKF2
resolver
uniprot_entry
EFC4B_MOUSE
resolver
uniprot_sec
A0A1D5RLZ8
resolver
uniprot_sec
B9EKF2
resolver
amino_acid_sequence
MATPSGREDSSSQTPGHGKQGSGACVEQLDHPEKLEVEMPDQSAMWKKAQEFFQTCDSEGKGFIARTDMQRLHQELPLSLEELEDVFDALDADGNGFLTPEEFTTGFSHFFFSQNIQGEEEADQQVAQLQEEKVYQSRGEEDVGDMDHDEEAQFQMLMDRLGAQKVLEDESDVRQLWLQLRKDEPHLLSNFEDLLTTIFAQLQEAHEQKNELECALRKKIAAYDEEIQHLYEEMEQQIKSEREQFLLKDTERFQARSRELEKKLSAKEQELERLNQKQRKLEGQCAALHNDKHETKAENSKLRLTNQELARELERTSHQLQEAQQQLESLQREACELQQEKEMEVYRVTESLQREKSGLLKQLDFLRERNKHLRDERDITFQKDKAAKANTAASKASRKQRSGSVIGKYVDGRGILRSQSEEEEDVFSAPRRRSSVGLSAYLQAEEDLGTGEPGSGVPRRQALRRIISIEEDPLPQLLEGGFEKPLSRCPEEEEVSDQGTERQSVAAPVLDLIPTSPRGQPVGKETLYKEERVPSTPDRLFKIVFVGDSAVGKTSFLRRLCEARFSPGMAATVGIDYRVKTVTVDNAQVALQLWDTAGQERYRCISQQFFRKADGVAVMYDLTAKQSFLSIRQWLSSVEEAVGDRIPVLLLGNKLDNEKEREVPRGLGEQLAKENNLIFYECSACSGHNAQESLLHLARLLKEQEDTVRNDTIQVGPPAKKKSCCG
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: [Isoform 1]: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex (By similarity). {ECO:0000250|UniProtKB:Q9BSW2}.; FUNCTION: [Isoform 2]: Rab GTPase that mediates the trafficking of Weibel-Palade bodies (WPBs) to microtubule organizing center (MTOC) in endothelial cells in response to acute inflammatory stimuli (By similarity). During histamine (but not thrombin) stimulation of endothelial cells, the dynein-bound form induces retrograde transport of a subset of WPBs along microtubules to the MTOC in a Ca(2+)-independent manner and its GTPase activity is essential for this function (By similarity). Ca(2+)-regulated dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules and regulates endosomal trafficking of CD47 (By similarity). Acts as an intracellular signaling module bridging two important T-cell receptor (TCR) signaling pathways, Ca(2+)-NFAT and JNK, to affect T-cell activation (PubMed:27016526). In resting T-cells, is predominantly localized near TGN network in a GTP-bound form, upon TCR stimulation, localizes at the immunological synapse via interaction with VAV1 to activate downstream Ca(2+)-NFAT and JNK signaling pathways (By similarity). Plays a role in T-helper 1 (Th1) cell differentiation and T-helper 17 (Th17) cell effector function (PubMed:29987160). Plays a role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation (By similarity). {ECO:0000250|UniProtKB:Q9BSW2, ECO:0000269|PubMed:27016526, ECO:0000269|PubMed:29987160}.
uniprot
proteins
mass_dalton
82667
uniprot
proteins
protein_family
EFCAB4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27016526
uniprot
proteins
pubmed
29987160
uniprot
proteins
sequence_length
726
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:Q9BSW2}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:Q9BSW2}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q9BSW2}. Cell membrane {ECO:0000250|UniProtKB:Q9BSW2}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9BSW2}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9BSW2}. Vesicle {ECO:0000250|UniProtKB:Q9BSW2}. Note=T-cell activation-induced elevation of intracellular of Ca(2+) stimulates its transport toward the microtubule organizing center (MTOC). Histamine stimulation induces a trafficking to the MTOC in a GTP-binding-dependent but Ca(2+)-binding-independent manner. Localizes to Golgi membrane in resting T-cells and upon its interaction with VAV1, is translocated from the Golgi membrane to the immunological synapse via subsynaptic vesicles. Its localization in the Golgi membrane requires isoprenylation and GTP-binding. {ECO:0000250|UniProtKB:Q9BSW2}.
uniprot
proteins