Fancl
entrez
67030
canonical
uniprot
Q9CR14
canonical
ensembl
ENSMUSG00000004018
resolver
ensp
ENSMUSP00000004120
resolver
ensp
ENSMUSP00000105135
resolver
genesymbol
Fancl
resolver
genesymbol_syn
Phf9
resolver
genesymbol_syn
Pog
resolver
uniprot
Q3TGY2
resolver
uniprot
Q9D017
resolver
uniprot_entry
FANCL_MOUSE
resolver
uniprot_sec
Q3TGY2
resolver
uniprot_sec
Q9D017
resolver
amino_acid_sequence
MDEAEASLLRHFPLLLPQNREKTVYEGFISAQGSDFHLRIVLPKDLQLKKARLLCSLQLKNILNEYHQVVQQRMKHSPDLMSFMMELKMILEVALKNKQELCVQPPSCSFCKDLLTEIGAIGWDKLACVESSFSTIKLKADDASGRKHLITVKLKAKYPVEPPDCVVDFPVPFSVSWTPQSSLVDVYSQFLVALETLKVFWDVMDEIDEKTWVLEPEKPPRSATARRIALGKNVSIAIEVDPRHPTMLPEFCFLGADHVTKPLGMKLSGSIHLWDPENSLLQNLKDVLEIDFPARSILEESDFSMDCGICYARHLNGAIPDQVCNNPQCGQPFHEICLYEWLRGLSTSRQSFNVFFGDCPYCSKPITLKMSGRKP
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Fancl are a cause of the gcd (germ cell deficient) mutant phenotype, which leads to reduced numbers of precursor germ cells and adult sterility, probably due to a reduced precursor germ cells proliferation.
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. {ECO:0000269|PubMed:12417526, ECO:0000269|PubMed:12606378}.
uniprot
proteins
mass_dalton
42527
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: The RING-type zinc finger domain is monoubiquitinated in the presence of UBE2T and UBE2W.
uniprot
proteins
pubmed
12417526
uniprot
proteins
pubmed
12574169
uniprot
proteins
pubmed
12606378
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21229326
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21229326}. Nucleus {ECO:0000269|PubMed:21229326}. Note=In the nucleus, colocalizes with UBE2W.
uniprot
proteins