KRTCAP2
entrez
200185
canonical
uniprot
Q8N6L1
canonical
ensembl
ENSG00000163463
resolver
ensp
ENSP00000295682
resolver
genesymbol
KRTCAP2
resolver
genesymbol_syn
KCP2
resolver
hgnc
HGNC:28942
resolver
uniprot
B2R4Q1
resolver
uniprot
Q6PG45
resolver
uniprot
Q86XW2
resolver
uniprot
Q8IWS4
resolver
uniprot_entry
KTAP2_HUMAN
resolver
uniprot_sec
B2R4Q1
resolver
uniprot_sec
Q6PG45
resolver
uniprot_sec
Q86XW2
resolver
uniprot_sec
Q8IWS4
resolver
amino_acid_sequence
MVVGTGTSLALSSLLSLLLFAGMQMYSRQLASTEWLTIQGGLLGSGLFVFSLTAFNNLENLVFGKGFQAKIFPEILLCLLLALFASGLIHRVCVTTCFIFSMVGLYYINKISSTLYQAAAPVLTPAKVTGKSKKRN
uniprot
proteins
function
FUNCTION: Subunit of STT3A-containing oligosaccharyl transferase (OST-A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:22467853, PubMed:28860277). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER) (PubMed:22467853, PubMed:28860277). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex (PubMed:28860277). May be involved in N-glycosylation of APP (amyloid-beta precursor protein) (PubMed:21768116). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1 (PubMed:21768116). {ECO:0000269|PubMed:21768116, ECO:0000269|PubMed:22467853, ECO:0000269|PubMed:28860277}.
uniprot
proteins
mass_dalton
14679
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:22467853, ECO:0000269|PubMed:28860277}.
uniprot
proteins
protein_family
KRTCAP2 family
uniprot
proteins
pubmed
12752121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21768116
uniprot
proteins
pubmed
22266900
uniprot
proteins
pubmed
22467853
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28860277
uniprot
proteins
sequence_length
136
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:21768116}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22266900}; Multi-pass membrane protein {ECO:0000269|PubMed:22266900}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..23; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 35..55; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 76..108; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins