Gabra5
entrez
110886
canonical
uniprot
Q8BHJ7
canonical
ensembl
ENSMUSG00000055078
resolver
ensp
ENSMUSP00000063276
resolver
ensp
ENSMUSP00000145685
resolver
ensp
ENSMUSP00000146238
resolver
ensp
ENSMUSP00000164323
resolver
ensp
ENSMUSP00000164328
resolver
ensp
ENSMUSP00000164330
resolver
ensp
ENSMUSP00000164336
resolver
enst
ENSMUST00000068456
resolver
enst
ENSMUST00000206382
resolver
enst
ENSMUST00000206734
resolver
genesymbol
Gabra5
resolver
uniprot_entry
GBRA5_MOUSE
resolver
amino_acid_sequence
MDNGMLSRFIMTQTLLVFCISMTLSSHFGFSQMPTSSVQDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKERELILNKSTNAFTTGKLTHPPNIPKEQPPAGTANAPTVSIKASEEKTAESKKTYNSISKIDKMSRIVFPILFGTFNLVYWATYLNREPVIKGATSPK
uniprot
proteins
function
FUNCTION: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABAARs containing alpha-5/GABRA5 are mainly extrasynaptic and contribute to the tonic GABAergic inhibition of the hippocampus (PubMed:14993607). Extrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes (PubMed:14993607). {ECO:0000250|UniProtKB:P14867, ECO:0000250|UniProtKB:P31644, ECO:0000269|PubMed:14993607}.
uniprot
proteins
mass_dalton
52274
uniprot
proteins
protein_family
GABRA5 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
14993607
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P31644}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31644}. Cell membrane {ECO:0000250|UniProtKB:P31644}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31644}.
uniprot
proteins
transmembrane_region
TRANSMEM 261..281; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P31644"; TRANSMEM 287..308; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P31644"; TRANSMEM 319..340; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P31644"; TRANSMEM 429..449; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P31644
uniprot
proteins