Taar1
entrez
111174
canonical
uniprot
Q923Y8
canonical
ensembl
ENSMUSG00000056379
resolver
ensp
ENSMUSP00000049527
resolver
enst
ENSMUST00000051532
resolver
genesymbol
Taar1
resolver
genesymbol_syn
Ta1
resolver
genesymbol_syn
Tar1
resolver
genesymbol_syn
Trar1
resolver
uniprot
Q05A85
resolver
uniprot_entry
TAAR1_MOUSE
resolver
uniprot_sec
Q05A85
resolver
activity_regulation
ACTIVITY REGULATION: Activated by SEP-363856 small molecule: IHCH-7179 acts both as an agonist activator for HTR1A and TAAR1. {ECO:0000269|PubMed:37935376}.
uniprot
proteins
amino_acid_sequence
MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
uniprot
proteins
function
FUNCTION: Intracellular G protein-coupled receptor for trace amines, which recognizes endogenous amine-containing metabolites such as beta-phenylethylamine (beta-PEA), 3-iodothyronamine (T1AM), isoamylamine (IAA), cadaverine (CAD), cyclohexylamine (CHA), p-tyramine (p-TYR), trimethylamine (TMA), octopamine and tryptamine (PubMed:15718104, PubMed:17212650, PubMed:37935376, PubMed:37963465). Also functions as a receptor for various drugs and psychoactive substances, such as amphetamine and methamphetamine (PubMed:17212650, PubMed:37935376). Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin (By similarity). Expressed in both the central and peripheral nervous system: TAAR1 activation regulates the activity of several neurotransmitter signaling pathways by (1) decreasing the basal firing rates of the neurons involved and by (2) lowering the sensitivity of receptors to neurotransmitters (PubMed:37935376, PubMed:37963465). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:37935376, PubMed:37963465). TAAR1 is coupled with different G(i)/G(o)-, G(s)- or G(q)/G(11) classes of G alpha proteins depending on the ligand (PubMed:37935376, PubMed:37963465). CAD-binding is coupled to G(i)/G(o) G alpha proteins and mediates inhibition of adenylate cyclase activity (PubMed:37935376, PubMed:37963465). T1AM- or beta-PEA-binding is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:37935376, PubMed:37963465). CHA- or IAA-binding is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers (PubMed:37935376, PubMed:37963465). TMA-binding is coupled with all three G(i)/G(o)-, G(s)- or G(q)/G(11) G alpha protein subtypes (PubMed:37935376, PubMed:37963465). {ECO:0000250|UniProtKB:Q96RJ0, ECO:0000269|PubMed:15718104, ECO:0000269|PubMed:17212650, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465}.
uniprot
proteins
mass_dalton
37621
uniprot
proteins
mutagenesis
MUTAGEN 102; /note="D->A: Abolished activation of G(s) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 103; /note="I->A: Reduced activation of G(q)/G(11) and G(s) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37963465"; MUTAGEN 106; /note="S->A: Reduced activation of G(s) G alpha proteins in response to beta-phenylethylamine-binding. Does not affect activation of G(q) G alpha proteins in response to cyclohexylamine-binding."; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465"; MUTAGEN 153; /note="Y->A: Reduced activation of G(s) G alpha proteins in response to beta-phenylethylamine-binding. Does not affect activation of G(q) G alpha proteins in response to cyclohexylamine-binding."; /evidence="ECO:0000269|PubMed:37963465"; MUTAGEN 183; /note="P->A: Reduced activation of G(s) G alpha proteins in response to beta-phenylethylamine-binding. Does not affect activation of G(q) G alpha proteins in response to cyclohexylamine-binding."; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465"; MUTAGEN 185; /note="F->A: Reduced activation of G(q)/G(11) and G(s) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465"; MUTAGEN 261; /note="W->A: Abolished activation of G alpha proteins in response to 3-iodothyronamine-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 264; /note="F->A: Abolished activation of G alpha proteins in response to 3-iodothyronamine-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 265; /note="F->A: Reduced activation of G(q)/G(11) and G(s) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465"; MUTAGEN 287; /note="Y->A: Reduced activation of Taar1 in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37963465"; MUTAGEN 291; /note="Y->A: Abolished activation of G(s) G alpha proteins in response to beta-phenylethylamine-binding. Does not affect activation of G(q) G alpha proteins in response to cyclohexylamine-binding."; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11459929
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15718104
uniprot
proteins
pubmed
17212650
uniprot
proteins
pubmed
22079347
uniprot
proteins
pubmed
26640076
uniprot
proteins
pubmed
37225986
uniprot
proteins
pubmed
37935376
uniprot
proteins
pubmed
37963465
uniprot
proteins
sequence_length
332
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250|UniProtKB:Q96RJ0}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96RJ0}; Multi-pass membrane protein {ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465}. Cell membrane {ECO:0000269|PubMed:37225986}; Multi-pass membrane protein {ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465}. Note=Localizes mainly intracellularly. Partially colocalizes with the endoplasmic reticulum; also found at lower lever at the plasma membrane. {ECO:0000250|UniProtKB:Q96RJ0}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..48; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465"; TRANSMEM 59..80; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465"; TRANSMEM 96..118; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465"; TRANSMEM 139..160; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465"; TRANSMEM 188..210; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465"; TRANSMEM 247..270; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465"; TRANSMEM 284..304; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37963465
uniprot
proteins