Clcnkb
entrez
56365
canonical
uniprot
Q9WUB6
canonical
ensembl
ENSMUSG00000006216
resolver
ensp
ENSMUSP00000006378
resolver
genesymbol
Clcnkb
resolver
genesymbol_syn
Clckb
resolver
genesymbol_syn
Clcnk1l
resolver
uniprot
A2ADB6
resolver
uniprot
Q8VCF8
resolver
uniprot_entry
CLCKB_MOUSE
resolver
uniprot_sec
A2ADB6
resolver
uniprot_sec
Q8VCF8
resolver
amino_acid_sequence
MEELVGLREGASKKPVPLQELWGPCPRIRRNIQGGLEWLKERLFRVGEDWYFLVALGVLMALISYAMNFTIGRVVRAHKWLYREIGDGHLLRYLSWTVYPVALLSFSSGFSQSITPSSGGSGIPEVKTILTGVVLEDYLDIKNFGAKVVGLSCTLATGSTIFLGKLGPFVHLSVMIAAYLGRVRTKTVGEPESKTKEMELLAAGAAVGVATVFAAPISGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFHLLAVFNNEQETITSIYKTSFPVDIPFDLPEIFFFVALGAICGILSCGYNYSQRTFLFFLKANGFTSKLLATSKPLYSALAAVVLASITYPPGVGHFMASRLSMSEHLETLFDNNSWALMTKNSSPPWAAEPDPQKLWLEWCHPQLTVFGTLVFFLVMKFWMLILATTIPIPAGYFLPIFIYGAVIGRLFGEVLSVAFPEGIVAGGRVNPIMPGAYALAGAAAFSGAVTHTLSTALLAFEVTGQLVHALPVLMAVLAANAISQSFQPSFYDGTIIVKKLPYLPWIRGRQIGSHSVTVGHFMNCALTTLAKDMPLEQVIQVVISTDVTQYPLVETTESQTLVGVVKRTHLVQALQTEPASWAPGQQPCLQDILANGCPTQPVTLQLSLETSLHETHNLFELLNLQTLFVTSRGRAVGSVSWVELKKAISTLTNPPAPK
uniprot
proteins
function
FUNCTION: Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide (By similarity). Forms a homodimeric channel where each subunit has its own ion conduction pathway. May conduct double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously (By similarity). Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain and functional switch to the ion conducting state. CLCNKB:BSND channels display mostly a linear current-voltage relationship controlled by common gate (By similarity). Mediates chloride conductance along nephron segments, namely the thick ascending limb of Henle's loop, convoluted tubule and the collecting duct, contributing to the maintenance of systemic acid-base and electrolyte homeostasis (PubMed:27335120, PubMed:34499620, PubMed:35349181). Conducts chloride currents in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (By similarity). {ECO:0000250|UniProtKB:P51801, ECO:0000269|PubMed:27335120, ECO:0000269|PubMed:34499620, ECO:0000269|PubMed:35349181}.
uniprot
proteins
mass_dalton
75009
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P51801}.
uniprot
proteins
protein_family
CLCNKB subfamily
uniprot
proteins
protein_family
Chloride channel (TC 2.A.49) family
uniprot
proteins
pubmed
11014860
uniprot
proteins
pubmed
11734858
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27335120
uniprot
proteins
pubmed
34499620
uniprot
proteins
pubmed
35349181
uniprot
proteins
sequence_length
687
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:27335120, ECO:0000305|PubMed:11734858}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..82; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 91..111; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 141..160; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 161..180; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 236..255; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 282..310; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 325..342; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 400..420; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 421..440; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 500..520; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523
uniprot
proteins