Ptpn1
entrez
24697
canonical
uniprot
P20417
canonical
ensembl
ENSRNOG00000010574
resolver
ensembl
ENSRNOG00055004794
resolver
ensembl
ENSRNOG00060001094
resolver
ensembl
ENSRNOG00065013113
resolver
ensp
ENSRNOP00000014309
resolver
ensp
ENSRNOP00000077114
resolver
ensp
ENSRNOP00055005751
resolver
ensp
ENSRNOP00060000740
resolver
ensp
ENSRNOP00065016650
resolver
enst
ENSRNOT00000014309
resolver
enst
ENSRNOT00055007632
resolver
enst
ENSRNOT00060001509
resolver
enst
ENSRNOT00065021500
resolver
genesymbol
Ptpn1
resolver
uniprot_entry
PTN1_RAT
resolver
amino_acid_sequence
MEMEKEFEQIDKAGNWAAIYQDIRHEASDFPCRIAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRIMEKGSLKCAQYWPQKEEKEMVFDDTNLKLTLISEDVKSYYTVRQLELENLATQEAREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRRFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHVPPPPRPPKRTLEPHNGKCKELFSNHQWVSEESCEDEDILAREESRAPSIAVHSMSSMSQDTEVRKRMVGGGLQSAQASVPTEEELSPTEEEQKAHRPVHWKPFLVNVCMATALATGAYLCYRVCFH
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
49674
uniprot
proteins
post_translational_modification
PTM: Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50 (By similarity). {ECO:0000250}.; PTM: S-nitrosylation of Cys-215 inactivates the enzyme activity. {ECO:0000250}.; PTM: Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity. {ECO:0000250}.
uniprot
proteins
protein_family
Non-receptor class 1 subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1599438
uniprot
proteins
pubmed
2154749
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Interacts with EPHA3 at the cell membrane. {ECO:0000250}.
uniprot
proteins