Mfsd12
entrez
73822
canonical
uniprot
Q3U481
canonical
ensembl
ENSMUSG00000034854
resolver
ensp
ENSMUSP00000036116
resolver
ensp
ENSMUSP00000281968
resolver
enst
ENSMUST00000044844
resolver
genesymbol
Mfsd12
resolver
uniprot
Q3U376
resolver
uniprot_entry
MFS12_MOUSE
resolver
uniprot_sec
Q3U376
resolver
amino_acid_sequence
MSPPSDDAGPGPPRTLSLAARLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRASCVRCGPRKAWHLAGTVCVLLSFPFIFSPCLGCGEATPEWAALLYYGPFIVVFQFGWAATQIAHLSLIPELVTSDHEKVELTALRYAFTVVANITVYGAAWLLLHLQGSAHGEQDISVGDQLGVQDVPVFRNLALLVVGVGAIFSLLFHLGTKEGHRSQHWGNEPNEHTPLVAPAAQPLLLWKHWLREPAFYQVGMLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVNRRIGRNMTYFTGLLVILAFAAWVALADNLGVAVYGAAVLLGAGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFSDKVANGLAVMAVQSLHPCPSELCCGACISFYHWVMTAVTGGVGVAAALALCSLLIWPIRIRNRDPRDRP
uniprot
proteins
function
FUNCTION: Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin/hair pigmentation (PubMed:33208952). In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin/hair pigmentation (PubMed:33208952). Also catalyzes import of cysteine into lysosomes in non-pigmented cells, regulating lysosomal cystine and cysteine storage, which is essential for redox homeostasis (By similarity). {ECO:0000250|UniProtKB:Q6NUT3, ECO:0000269|PubMed:33208952}.
uniprot
proteins
mass_dalton
51504
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-251 by MTOR via mTORC1 pathway promotes cysteine transport in lysosomes, thereby regulating lysosomal cysteine and cystine storage and redox homeostasis. {ECO:0000250|UniProtKB:Q6NUT3}.
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
29025994
uniprot
proteins
pubmed
33208952
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000250|UniProtKB:Q6NUT3}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q6NUT3}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 56..76; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 95..115; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 122..142; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 285..305; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 307..327; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 365..385; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 399..419; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 445..465; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins