Smad5
entrez
17129
canonical
uniprot
P97454
canonical
ensembl
ENSMUSG00000021540
resolver
ensp
ENSMUSP00000065798
resolver
ensp
ENSMUSP00000105500
resolver
ensp
ENSMUSP00000105502
resolver
ensp
ENSMUSP00000276672
resolver
ensp
ENSMUSP00000276673
resolver
ensp
ENSMUSP00000276674
resolver
ensp
ENSMUSP00000276675
resolver
enst
ENSMUST00000069557
resolver
enst
ENSMUST00000109874
resolver
enst
ENSMUST00000109876
resolver
genesymbol
Smad5
resolver
genesymbol_syn
Madh5
resolver
genesymbol_syn
Msmad5
resolver
uniprot
P70341
resolver
uniprot
Q810K0
resolver
uniprot_entry
SMAD5_MOUSE
resolver
uniprot_sec
P70341
resolver
uniprot_sec
Q810K0
resolver
amino_acid_sequence
MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNAPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMAPDNSQPMDTSSNMIPQTMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS
uniprot
proteins
function
FUNCTION: Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis (PubMed:10079220, PubMed:12393578). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:26304548). Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes. Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis. {ECO:0000250|UniProtKB:Q99717, ECO:0000269|PubMed:10079220, ECO:0000269|PubMed:12393578}.
uniprot
proteins
mass_dalton
52172
uniprot
proteins
mutagenesis
MUTAGEN 80; /note="H->A: Exhibits impaired binding affinity to GC-BREDNA sequence."; /evidence="ECO:0000269|PubMed:26304548
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase. {ECO:0000250|UniProtKB:Q99717}.; PTM: Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1. {ECO:0000250|UniProtKB:Q99717}.
uniprot
proteins
protein_family
Dwarfin/SMAD family
uniprot
proteins
pubmed
10079220
uniprot
proteins
pubmed
10708952
uniprot
proteins
pubmed
12370310
uniprot
proteins
pubmed
12393578
uniprot
proteins
pubmed
15221015
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21239498
uniprot
proteins
pubmed
26304548
uniprot
proteins
pubmed
8799132
uniprot
proteins
pubmed
9076683
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99717}. Nucleus {ECO:0000250|UniProtKB:Q99717}. Mitochondrion {ECO:0000250|UniProtKB:Q99717}. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. {ECO:0000250|UniProtKB:Q99717}.
uniprot
proteins