Cdc26
entrez
366381
canonical
uniprot
Q6YDN7
canonical
ensembl
ENSRNOG00000090496
resolver
ensembl
ENSRNOG00055019546
resolver
ensembl
ENSRNOG00060009971
resolver
ensembl
ENSRNOG00065015890
resolver
ensp
ENSRNOP00000106547
resolver
ensp
ENSRNOP00055027074
resolver
ensp
ENSRNOP00060013169
resolver
ensp
ENSRNOP00065020702
resolver
enst
ENSRNOT00000141508
resolver
enst
ENSRNOT00055033365
resolver
enst
ENSRNOT00060016849
resolver
enst
ENSRNOT00065026394
resolver
genesymbol
Cdc26
resolver
uniprot_entry
CDC26_RAT
resolver
amino_acid_sequence
MLRRKPTRLELKLDDIEEFENIRKDLEARKKQKEDVEGVGTSDGEGAAGLSSDPKSREQMINDRIGYKPQLKTNNRTSQFGNFEF
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). Together with the RING-H2 protein ANAPC11, forms the catalytic component of the E3 ubiquitin ligase complex (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). {ECO:0000250|UniProtKB:Q8NHZ8}.
uniprot
proteins
mass_dalton
9802
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8NHZ8}.
uniprot
proteins
protein_family
CDC26 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
85
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins