Cisd2
entrez
67006
canonical
uniprot
Q9CQB5
canonical
ensembl
ENSMUSG00000028165
resolver
ensp
ENSMUSP00000029815
resolver
enst
ENSMUST00000029815
resolver
genesymbol
Cisd2
resolver
genesymbol_syn
Cdgsh2
resolver
genesymbol_syn
Noxp70
resolver
genesymbol_syn
Zcd2
resolver
uniprot
Q9D0Y0
resolver
uniprot_entry
CISD2_MOUSE
resolver
uniprot_sec
Q9D0Y0
resolver
amino_acid_sequence
MVLDSVARIVKVQLPAYLKQLPVPDSITGFARLTVSDWLRLLPFLGVLALLGYLAVRPFFPKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNELTGDNVGPLILKKKEV
uniprot
proteins
function
FUNCTION: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy (By similarity). {ECO:0000250, ECO:0000269|PubMed:19451219}.
uniprot
proteins
mass_dalton
15242
uniprot
proteins
protein_family
CISD protein family
uniprot
proteins
protein_family
CISD2 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17029606
uniprot
proteins
pubmed
19451219
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
135
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19451219}; Single-pass membrane protein {ECO:0000269|PubMed:19451219}. Mitochondrion outer membrane {ECO:0000269|PubMed:19451219}; Single-pass membrane protein {ECO:0000269|PubMed:19451219}. Note=According to PubMed:19451219, it mainly localizes to the mitochondrion outer membrane and localizes only at low level to the endoplasmic reticulum. However, inverse results are observed in human cells.
uniprot
proteins
transmembrane_region
TRANSMEM 38..60; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins