Clcn5
entrez
12728
canonical
uniprot
Q9WVD4
canonical
ensembl
ENSMUSG00000004317
resolver
ensp
ENSMUSP00000004428
resolver
ensp
ENSMUSP00000111412
resolver
genesymbol
Clcn5
resolver
genesymbol_syn
Clc5
resolver
uniprot
B1ATV0
resolver
uniprot
B1AXN0
resolver
uniprot
Q3UL16
resolver
uniprot
Q8C6W8
resolver
uniprot_entry
CLCN5_MOUSE
resolver
uniprot_entry
Q3UL16_MOUSE
resolver
uniprot_entry
Q8C6W8_MOUSE
resolver
uniprot_sec
B1ATV0
resolver
uniprot_sec
B1AXN0
resolver
amino_acid_sequence
MAMWQGAMDNRGFHQGSFSSFQSSSSDEDLMDIPGTAMDFSMRDDVPPLDREIEGNKSYNGGGIGSSNRVMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEHRDKCPEWNSWAQLIINTDQGAFAYIVNYFMYVLWALLFAFLAVSLVKAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFIVLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVVEVLIVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENHFNTSKGGELPDRPAGVGIYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHHDWGIFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPMPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN
uniprot
proteins
function
FUNCTION: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). {ECO:0000250|UniProtKB:P51795, ECO:0000305}.
uniprot
proteins
mass_dalton
90706
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation. {ECO:0000250|UniProtKB:P51795}.
uniprot
proteins
protein_family
Chloride channel (TC 2.A.49) family
uniprot
proteins
protein_family
ClC-5/CLCN5 subfamily
uniprot
proteins
pubmed
10373326
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
816
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:P51795}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51795}. Endosome membrane {ECO:0000250|UniProtKB:P51795}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51795}. Cell membrane {ECO:0000250|UniProtKB:P51795}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51795}.
uniprot
proteins
transmembrane_region
TRANSMEM 125..162; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 208..231; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 256..275; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 281..300; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 348..366; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 389..414; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 422..442; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 498..518; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 523..542; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 605..622; /note="Helical"; /evidence="ECO:0000250
uniprot
proteins