Psmc2
entrez
19181
canonical
uniprot
P46471
canonical
ensembl
ENSMUSG00000028932
resolver
ensp
ENSMUSP00000030769
resolver
ensp
ENSMUSP00000159299
resolver
ensp
ENSMUSP00000176043
resolver
enst
ENSMUST00000030769
resolver
enst
ENSMUST00000239497
resolver
genesymbol
Psmc2
resolver
genesymbol_syn
Mss1
resolver
uniprot
A0A6I8MWX4
resolver
uniprot
O08531
resolver
uniprot
Q3TGX5
resolver
uniprot
Q8BVQ9
resolver
uniprot
Q9DBA1
resolver
uniprot_entry
A0A6I8MWX4_MOUSE
resolver
uniprot_entry
PRS7_MOUSE
resolver
uniprot_entry
Q8BVQ9_MOUSE
resolver
uniprot_sec
O08531
resolver
uniprot_sec
Q3TGX5
resolver
uniprot_sec
Q9DBA1
resolver
amino_acid_sequence
MPDYLGADQRKTKEEEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000250|UniProtKB:P35998}.
uniprot
proteins
mass_dalton
48648
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated by RNF181. {ECO:0000250|UniProtKB:P35998}.; PTM: Phosphorylated. Dephosphorylated by UBLCP1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly. {ECO:0000250|UniProtKB:P35998}.
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16857966
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22078707
uniprot
proteins
pubmed
8247131
uniprot
proteins
pubmed
9353061
uniprot
proteins
sequence_length
433
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P35998}. Note=Colocalizes with TRIM5 in cytoplasmic bodies. {ECO:0000250|UniProtKB:P35998}.
uniprot
proteins