Slc46a1
entrez
52466
canonical
uniprot
Q6PEM8
canonical
ensembl
ENSMUSG00000020829
resolver
ensp
ENSMUSP00000001126
resolver
enst
ENSMUST00000001126
resolver
genesymbol
Slc46a1
resolver
genesymbol_syn
D11Ertd18e
resolver
genesymbol_syn
Hcp1
resolver
genesymbol_syn
Pcft
resolver
uniprot
Q571I8
resolver
uniprot
Q5SYG0
resolver
uniprot
Q8R1H7
resolver
uniprot
Q9D1P1
resolver
uniprot_entry
PCFT_MOUSE
resolver
uniprot_sec
Q571I8
resolver
uniprot_sec
Q5SYG0
resolver
uniprot_sec
Q8R1H7
resolver
uniprot_sec
Q9D1P1
resolver
amino_acid_sequence
MEGRVSSVGSPHSFLNAPVLFRGPVEPLVFLANFALVLQGPLTTQYLWHRFSTELGYNGTRHRENCGNQSADPLMKEVETLTSHWTLYMNVGGFLVGLFWSTLLGAWSDRVGRRPLLVLASLGLLLQAVVSIFVVQLELHVGFFVLGRALCALLGDFNGLLAASFASVADVSSNHSRTFRMALLEACIGVAGTLASLLGGHWLRAQGYANPFWLALALLIVMALYAAFCFGETVKEPKSTRLFTLRHHRSIARLYVVPAPEKSRMHLALYSLAIFVVVTVHFGAQDILTLYELSAPLCWDSKLIGYGSAAQHLPYLTSLLGLRLLQFCLADTWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVTTPVIRAKLSKLVSESEQGALFSAVACVNSLAMLMASGIFNSIYPATLNFMKGFPFLLGAGLLFIPAILIGVLEKVNPHPEFQQFPQSP
uniprot
proteins
function
FUNCTION: Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:17962486). Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (PubMed:17962486). Functions at acidic pH via alternate outward- and inward-open conformation states (By similarity). Protonation of residues in the outward open state primes the protein for transport (By similarity). Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (By similarity). Also able to transport antifolate drugs, such as methotrexate and pemetrexed (PubMed:17962486). Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes (By similarity). Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (PubMed:16143108). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (PubMed:22058337). Hence, participates in the trafficking of heme and increases intracellular iron content (By similarity). {ECO:0000250|UniProtKB:Q96NT5, ECO:0000269|PubMed:16143108, ECO:0000269|PubMed:17962486, ECO:0000269|PubMed:22058337}.
uniprot
proteins
mass_dalton
50089
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
SLC46A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16143108
uniprot
proteins
pubmed
17962486
uniprot
proteins
pubmed
19074442
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21346251
uniprot
proteins
pubmed
22058337
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96NT5}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:16143108}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:19074442}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:Q96NT5}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:16143108}. Note=Shifts from the apical membrane of intestinal cells iron-deficient cells to the cytoplasm in response to increased in iron stores (PubMed:16143108). Localizes to the basolateral membrane of choroid plexus (PubMed:19074442). {ECO:0000269|PubMed:16143108, ECO:0000269|PubMed:19074442}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..44; /note="Helical; Name=TM1"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 83..108; /note="Helical; Name=TM2"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 113..135; /note="Helical; Name=TM3"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 141..154; /note="Helical; Name=TM4"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 178..203; /note="Helical; Name=TM5"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 209..227; /note="Helical; Name=TM6"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 267..289; /note="Helical; Name=TM7"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 303..325; /note="Helical; Name=TM8"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 332..351; /note="Helical; Name=TM9"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 356..376; /note="Helical; Name=TM10"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 389..414; /note="Helical; Name=TM11"; /evidence="ECO:0000250|UniProtKB:F1NJ67"; TRANSMEM 423..441; /note="Helical; Name=TM12"; /evidence="ECO:0000250|UniProtKB:F1NJ67
uniprot
proteins