Pip5k1c
entrez
314641
canonical
uniprot
Q5I6B8
canonical
ensembl
ENSRNOG00000020577
resolver
ensp
ENSRNOP00000057873
resolver
ensp
ENSRNOP00000068990
resolver
ensp
ENSRNOP00000097462
resolver
enst
ENSRNOT00000061159
resolver
enst
ENSRNOT00000088364
resolver
enst
ENSRNOT00000115219
resolver
genesymbol
Pip5k1c
resolver
uniprot
A0A0G2JU72
resolver
uniprot
A0A8I6ARF9
resolver
uniprot
F1M8H6
resolver
uniprot
Q3MID5
resolver
uniprot_entry
A0A0G2JU72_RAT
resolver
uniprot_entry
A0A8I6ARF9_RAT
resolver
uniprot_entry
F1M8H6_RAT
resolver
uniprot_entry
PI51C_RAT
resolver
uniprot_entry
Q3MID5_RAT
resolver
amino_acid_sequence
MELEVPDEAESAEAGAVTAEAAWSAESGAAAGMTQKKAILAEAPLVTGQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGNLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSVFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNVLPRVVKMHLKFDLKGSTYKRRASKKEKEKSLPTYKDLDFMQDMPEGLLLDSDTFGALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQQERERQAEGAQSKADEKRPVAQKALYSTARESIQGGAARGEAIETDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSSTVFRKSSSLKSSPSKKGRGALLAVKPLGPTAAFSASQIPSEREDVQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSDTSEQPRYRRRTQSSGQDGRPQEELHAEDLQKITVQVEPVCGVGVVVPKEQGAGVEVPPSGASAAATVEVDAASQASEPASQASDEEDAPSTDIYFFAHGRYWLFSPRRRRLRAVTPSHTGAPTDGRSWVYSPLHYSARPASDGESDT
uniprot
proteins
ec_number
2.7.1.68
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility. PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments (By similarity). Required for synaptic vesicle transport (By similarity). Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis. Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed:12847086). Required for clathrin-coated pits assembly at the synapse (PubMed:12847086). Participates in cell junction assembly. Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking. Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions. Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (By similarity). Required for uropodium formation and retraction of the cell rear during directed migration. Has a role in growth factor-stimulated directional cell migration and adhesion (By similarity). Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (By similarity). Negative regulator of T-cell activation and adhesion. Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor. Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (By similarity). {ECO:0000250|UniProtKB:O60331, ECO:0000250|UniProtKB:O70161, ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:12847086}.
uniprot
proteins
mass_dalton
75594
uniprot
proteins
mutagenesis
MUTAGEN 188; /note="K->A: Reduces activity by over 99%."; /evidence="ECO:0000269|PubMed:14741049"; MUTAGEN 316; /note="D->K: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:14741049
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-672 negatively regulates binding to TLN2 and is strongly stimulated in mitosis. Phosphorylation on Tyr-671 is necessary for targeting to focal adhesions. Phosphorylation on Ser-672 and Tyr-671 are mutually exclusive. Phosphorylated by SYK and CSK. Tyrosine phosphorylation is enhanced by PTK2 signaling. Phosphorylated at Tyr-635 upon EGF stimulation. Some studies suggest that phosphorylation on Tyr-671 enhances binding to tailins (TLN1 and TLN2) (By similarity); others that phosphorylation at Tyr-671 does not directly enhance binding to tailins (TLN1 and TLN2) but may act indirectly by inhibiting phosphorylation at Ser-672. {ECO:0000250}.; PTM: Acetylation at Lys-265 and Lys-268 seems to decrease lipid kinase activity. Deacetylation of these sites by SIRT1 positively regulates the exocytosis of TSH-containing granules from pituitary cells (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
12847086
uniprot
proteins
pubmed
14741049
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
688
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12847086}; Peripheral membrane protein {ECO:0000269|PubMed:12847086}; Cytoplasmic side {ECO:0000269|PubMed:12847086}. Endomembrane system {ECO:0000269|PubMed:12847086}. Cytoplasm {ECO:0000250|UniProtKB:O70161}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:O60331}. Cell junction, adherens junction {ECO:0000250|UniProtKB:O60331}. Cell projection, ruffle membrane {ECO:0000269|PubMed:12847086}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:O70161}. Cell projection, uropodium {ECO:0000250|UniProtKB:O70161}.
uniprot
proteins