Aak1
entrez
269774
canonical
uniprot
Q3UHJ0
canonical
ensembl
ENSMUSG00000057230
resolver
ensp
ENSMUSP00000003710
resolver
ensp
ENSMUSP00000086948
resolver
ensp
ENSMUSP00000175324
resolver
ensp
ENSMUSP00000175326
resolver
ensp
ENSMUSP00000175327
resolver
ensp
ENSMUSP00000175328
resolver
ensp
ENSMUSP00000175329
resolver
ensp
ENSMUSP00000175330
resolver
ensp
ENSMUSP00000175331
resolver
ensp
ENSMUSP00000175333
resolver
ensp
ENSMUSP00000175337
resolver
ensp
ENSMUSP00000175338
resolver
ensp
ENSMUSP00000175339
resolver
ensp
ENSMUSP00000175340
resolver
ensp
ENSMUSP00000175342
resolver
genesymbol
Aak1
resolver
genesymbol_syn
Kiaa1048
resolver
uniprot
B2RUJ0
resolver
uniprot
Q3TY53
resolver
uniprot
Q6ZPZ6
resolver
uniprot
Q80XP6
resolver
uniprot_entry
AAK1_MOUSE
resolver
uniprot_sec
B2RUJ0
resolver
uniprot_sec
Q3TY53
resolver
uniprot_sec
Q6ZPZ6
resolver
uniprot_sec
Q80XP6
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by clathrin. {ECO:0000250|UniProtKB:Q2M2I8}.
uniprot
proteins
amino_acid_sequence
MKKFFDSRREQGSSGLGSGSSGGGGSSSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFALVFLVRTSNGVKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQAEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGSFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPVPNVQNSPIPAKLPEPVKASEAAVKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPLPQAAGPSNQPGLLPSVSQPKAQATPSQPLQSSQPKQPQAPPTPQQTPATQTQGLPTQAQATPQHQQQHLLKQQQQQQQQPQQPTAPPQPAGTFYQQQQQQQQQQAQTQQFQAVHPAAQQPVTAQFPVGSQGGAQQQLMQNFYHQQQQQQQQQQQLMAQQAALQQKTAVVVPQSQAQPATAPQAAAAQEPGQIQAPVRQQPKVQTTPPPTIQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVSNASEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKLPEKLGGSAESLIPGFQPTQGDAFTTPSFSAGTAEKRKGGQAVDSGIPLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIDKADVAVESLIPGLEPPVAQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTAGLLEEFAPIALSAPTHKAAEDSNLISGFGVAEGSEKVAEDEFDPIPVLITKNTQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Preferentially, may phosphorylate substrates on threonine residues. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. {ECO:0000250|UniProtKB:Q2M2I8}.
uniprot
proteins
mass_dalton
103346
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000250|UniProtKB:Q2M2I8}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21464124
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
959
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:F1MH24}; Peripheral membrane protein {ECO:0000250|UniProtKB:F1MH24}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:P0C1X8}. Presynapse {ECO:0000250|UniProtKB:P0C1X8}. Note=Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells. {ECO:0000250|UniProtKB:P0C1X8}.
uniprot
proteins