Stk25
entrez
59041
canonical
uniprot
Q9Z2W1
canonical
ensembl
ENSMUSG00000026277
resolver
ensp
ENSMUSP00000027498
resolver
ensp
ENSMUSP00000167821
resolver
enst
ENSMUST00000027498
resolver
genesymbol
Stk25
resolver
genesymbol_syn
Sok1
resolver
uniprot
Q3U6Y0
resolver
uniprot
Q6IR17
resolver
uniprot_entry
Q3U6Y0_MOUSE
resolver
uniprot_entry
STK25_MOUSE
resolver
uniprot_sec
Q6IR17
resolver
activity_regulation
ACTIVITY REGULATION: Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-174, possibly as a consequence of stabilization of dimer formation. The C-terminal non-catalytic region inhibits the kinase activity (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MAHLRGFAHQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPTLEGHHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPIKRQPRSQCLSTLVRPVFGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFSHSRNHLTSTR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Oxidant stress-activated serine/threonine kinase that plays a role in metabolic homeostasis, neuronal polarization, cell migration, Golgi organization, apoptosis or innate immunity. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Functions as an inhibitor of the PKA pathway by affecting phosphorylation of the PRKAR1A regulatory subunit, which in turn suppresses the kinase activity of the catalytic subunit (PubMed:35977512). Positively regulates the TLR signaling by directly phosphorylating the transcription factor IRF5. {ECO:0000250|UniProtKB:O00506, ECO:0000269|PubMed:35977512}.
uniprot
proteins
mass_dalton
48158
uniprot
proteins
post_translational_modification
PTM: Undergoes autophosphorylation in response to multiple TLR ligands. {ECO:0000250|UniProtKB:O00506}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
35977512
uniprot
proteins
sequence_length
426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Localizes to the Golgi apparatus. {ECO:0000250}.
uniprot
proteins