Cinp
entrez
67236
canonical
uniprot
Q9D0V8
canonical
ensembl
ENSMUSG00000021276
resolver
ensp
ENSMUSP00000035245
resolver
ensp
ENSMUSP00000152272
resolver
enst
ENSMUST00000220607
resolver
genesymbol
Cinp
resolver
uniprot
A0A1Y7VN75
resolver
uniprot
Q8C063
resolver
uniprot
Q9D8P9
resolver
uniprot_entry
A0A1Y7VN75_MOUSE
resolver
uniprot_entry
CINP_MOUSE
resolver
uniprot_sec
Q8C063
resolver
uniprot_sec
Q9D8P9
resolver
amino_acid_sequence
MEAKTLGIATPRKPVLSVSARKLKDNAADWHNLILKWDSLSDKGFTTASSIANLKVSLLSKEKVELESSSPASMEEEEKTNLDYDKGLEALCEELQAILDGLTKIQMKMEKLSSTTKGICELENYHYREESSRPPLFHTWPTAFFYEVSRRLSEAYKKELLLKHTIGAELAHTADRNLSLTYLSMWLHQPYIESNSKLQLESMLLETGHRAL
uniprot
proteins
function
FUNCTION: Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling in response to DNA damage. Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. As part of 55LCC complex, also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. {ECO:0000250|UniProtKB:Q9BW66}.
uniprot
proteins
mass_dalton
24104
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDC7 but not by CDK2. {ECO:0000250|UniProtKB:Q9BW66}.
uniprot
proteins
protein_family
CINP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BW66}. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication. {ECO:0000250|UniProtKB:Q9BW66}.
uniprot
proteins