Meis1
entrez
17268
canonical
uniprot
Q60954
canonical
ensembl
ENSMUSG00000020160
resolver
ensp
ENSMUSP00000069277
resolver
ensp
ENSMUSP00000139219
resolver
ensp
ENSMUSP00000307454
resolver
ensp
ENSMUSP00000307459
resolver
genesymbol
Meis1
resolver
uniprot
B1ARH5
resolver
uniprot
Q5SVC8
resolver
uniprot
Q60955
resolver
uniprot
Q8CIL0
resolver
uniprot_entry
MEIS1_MOUSE
resolver
uniprot_sec
B1ARH5
resolver
uniprot_sec
Q5SVC8
resolver
uniprot_sec
Q60955
resolver
uniprot_sec
Q8CIL0
resolver
amino_acid_sequence
MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDVTRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGPMSGMGMNMGMEGQWHYM
uniprot
proteins
disease_involvement
DISEASE: Note=Meis1 serves as a site of viral integration in 15% of the tumors arising in BXH-2 mice that develop myeloid leukemia as a result of the expression of an ecotropic murine leukemia virus. {ECO:0000269|PubMed:7565694}.
uniprot
proteins
function
FUNCTION: Acts as a transcriptional regulator of PAX6. Also acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. {ECO:0000269|PubMed:12183364, ECO:0000269|PubMed:15882575}.
uniprot
proteins
mass_dalton
43002
uniprot
proteins
mutagenesis
MUTAGEN 213; /note="W->A: No effect on cooperative binding with PBX1 to CYP17."; /evidence="ECO:0000269|PubMed:9525891"; MUTAGEN 321; /note="N->S: Loss of binding to other proteins."; /evidence="ECO:0000269|PubMed:10523646
uniprot
proteins
protein_family
TALE/MEIS homeobox family
uniprot
proteins
pubmed
10082572
uniprot
proteins
pubmed
10523646
uniprot
proteins
pubmed
12183364
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15654074
uniprot
proteins
pubmed
15882575
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21059917
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7565694
uniprot
proteins
pubmed
9315626
uniprot
proteins
pubmed
9525891
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:10082572, ECO:0000269|PubMed:15882575}.
uniprot
proteins