GPR108
entrez
56927
canonical
uniprot
Q9NPR9
canonical
ensembl
ENSG00000125734
resolver
ensp
ENSP00000264080
resolver
ensp
ENSP00000401284
resolver
ensp
ENSP00000533637
resolver
ensp
ENSP00000639545
resolver
ensp
ENSP00000667486
resolver
ensp
ENSP00000667488
resolver
ensp
ENSP00000690507
resolver
enst
ENST00000264080
resolver
enst
ENST00000430424
resolver
genesymbol
GPR108
resolver
genesymbol_syn
LUSTR2
resolver
hgnc
HGNC:17829
resolver
uniprot
B9EJD7
resolver
uniprot
G5E9L6
resolver
uniprot_entry
G5E9L6_HUMAN
resolver
uniprot_entry
GP108_HUMAN
resolver
uniprot_sec
B9EJD7
resolver
amino_acid_sequence
MAVSERRGLGRGSPAEWGQRLLLVLLLGGCSGRIHQLALTGEKRADIQLNSFGFYTNGSLEVELSVLRLGLREAEEKSLLVGFSLSRVRSGRVRSYSTRDFQDCPLQKNSSSFLVLFLINTKDLQVQVRKYGEQKTLFIFPGLLPEAPSKPGLPKPQATVPRKVDGGGTSAASKPKSTPAVIQGPSGKDKDLVLGLSHLNNSYNFSFHVVIGSQAEEGQYSLNFHNCNNSVPGKEHPFDITVMIREKNPDGFLSAAEMPLFKLYMVMSACFLAAGIFWVSILCRNTYSVFKIHWLMAALAFTKSISLLFHSINYYFINSQGHPIEGLAVMYYIAHLLKGALLFITIALIGSGWAFIKYVLSDKEKKVFGIVIPMQVLANVAYIIIESREEGASDYVLWKEILFLVDLICCGAILFPVVWSIRHLQDASGTDGKVAVNLAKLKLFRHYYVMVICYVYFTRIIAILLQVAVPFQWQWLYQLLVEGSTLAFFVLTGYKFQPTGNNPYLQLPQEDEEDVQMEQVMTDSGFREGLSKVNKTASGRELL
uniprot
proteins
function
FUNCTION: May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response. {ECO:0000250|UniProtKB:Q91WD0}.; FUNCTION: (Microbial infection) Plays an essential function in adeno-associated virus (AAV) transduction across multiple serotypes except AAV5. May play a critical role in mediating the endosomal virus escape or in the AAV virions trafficking from endosomes to the nucleus. {ECO:0000269|PubMed:31784416, ECO:0000269|PubMed:32280726}.
uniprot
proteins
mass_dalton
60633
uniprot
proteins
protein_family
LU7TM family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
31784416
uniprot
proteins
pubmed
32280726
uniprot
proteins
sequence_length
543
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q91WD0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91WD0}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:31784416}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91WD0}. Golgi apparatus membrane {ECO:0000269|PubMed:32280726}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with TLR3, -7, -4, and -9. {ECO:0000250|UniProtKB:Q91WD0}.
uniprot
proteins
transmembrane_region
TRANSMEM 263..283; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 292..312; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 336..356; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 367..387; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 401..421; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 449..469; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 473..493; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins