ANKFY1
entrez
51479
canonical
uniprot
Q9P2R3
canonical
ensembl
ENSG00000185722
resolver
ensp
ENSP00000343362
resolver
ensp
ENSP00000459775
resolver
ensp
ENSP00000459943
resolver
genesymbol
ANKFY1
resolver
genesymbol_syn
ANKHZN
resolver
genesymbol_syn
KIAA1255
resolver
hgnc
HGNC:20763
resolver
uniprot
A8KA65
resolver
uniprot
B3KPZ0
resolver
uniprot
Q5RKV4
resolver
uniprot
Q9ULG5
resolver
uniprot_entry
ANFY1_HUMAN
resolver
uniprot_entry
B3KPZ0_HUMAN
resolver
uniprot_sec
A8KA65
resolver
uniprot_sec
Q5RKV4
resolver
uniprot_sec
Q9ULG5
resolver
amino_acid_sequence
MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEPPWCDGSYCYECTARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICFDVLTLGGVS
uniprot
proteins
function
FUNCTION: Proposed effector of Rab5 (PubMed:15328530). Binds to phosphatidylinositol 3-phosphate (PI[3]P) (PubMed:15328530). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of clathrin-coated vesicles with early endosomes (PubMed:15328530). Involved in macropinocytosis; the function is dependent on Rab5-GTP (PubMed:15328530). Required for correct endosomal localization (PubMed:15328530). Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB (PubMed:24102721). Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner (PubMed:22284051). Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport (PubMed:22284051). Required for podocyte migration (PubMed:29959197). {ECO:0000269|PubMed:15328530, ECO:0000269|PubMed:22284051, ECO:0000269|PubMed:24102721, ECO:0000269|PubMed:29959197}.
uniprot
proteins
mass_dalton
128399
uniprot
proteins
mutagenesis
MUTAGEN 421..423; /note="NPF->APA: Disrupts interaction with EHD1."; /evidence="ECO:0000269|PubMed:22284051"; MUTAGEN 424..425; /note="ED->AA: Decreases interaction with EHD1."; /evidence="ECO:0000269|PubMed:22284051
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
10940552
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15328530
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22284051
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24102721
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29959197
uniprot
proteins
sequence_length
1169
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10940552}. Endosome membrane {ECO:0000269|PubMed:10940552}; Peripheral membrane protein {ECO:0000269|PubMed:10940552}. Early endosome {ECO:0000269|PubMed:15328530, ECO:0000269|PubMed:22284051, ECO:0000269|PubMed:29959197}. Note=Also associated with endosomal membranes. Localizes to macropinosomes (PubMed:15328530). On endosomes, partially colocalizes with components of the retromer (PubMed:22284051). {ECO:0000269|PubMed:15328530, ECO:0000269|PubMed:22284051}.
uniprot
proteins