Mdm4
entrez
17248
canonical
uniprot
O35618
canonical
ensembl
ENSMUSG00000054387
resolver
ensp
ENSMUSP00000068661
resolver
ensp
ENSMUSP00000070411
resolver
ensp
ENSMUSP00000140609
resolver
ensp
ENSMUSP00000231614
resolver
ensp
ENSMUSP00000231620
resolver
enst
ENSMUST00000067398
resolver
genesymbol
Mdm4
resolver
genesymbol_syn
Mdmx
resolver
uniprot
F8WJ46
resolver
uniprot
Q3UTC9
resolver
uniprot
Q9CYG1
resolver
uniprot_entry
F8WJ46_MOUSE
resolver
uniprot_entry
MDM4_MOUSE
resolver
uniprot_entry
Q3UTC9_MOUSE
resolver
uniprot_sec
Q9CYG1
resolver
amino_acid_sequence
MTSHSTSAQCSASDSACRISSEQISQVRPKLQLLKILHAAGAQGEVFTMKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGDLLGCQSFSVKDPSPLYDMLRKNLVTSASINTDAAQTLALAQDHTMDFPSQDRLKHGATEYSNPRKRTEEEDTHTLPTSRHKCRDSRADEDLIEHLSQDETSRLDLDFEEWDVAGLPWWFLGNLRNNCIPKSNGSTDLQTNQDIGTAIVSDTTDDLWFLNETVSEQLGVGIKVEAANSEQTSEVGKTSNKKTVEVGKDDDLEDSRSLSDDTDVELTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSNITAIPEKKDNEGIDVPDCRRTISAPVVRPKDGYLKEEKPRFDPCNSVGFLDLAHSSESQEIISSAREQTDIFSEQKAETESMEDFQNVLKPCSLCEKRPRDGNIIHGKTSHLTTCFHCARRLKKSGASCPACKKEIQLVIKVFIA
uniprot
proteins
function
FUNCTION: Contributes to p53/TP53 regulation. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding their transcriptional activation domains. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000250|UniProtKB:O15151, ECO:0000269|PubMed:8895579}.; FUNCTION: [Isoform Short]: Acts as a more potent inhibitor of TP53 activity than the long isoform. {ECO:0000269|PubMed:10075736}.
uniprot
proteins
mass_dalton
54963
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation at Ser-367 promotes interaction with YWHAG and subsequent ubiquitination and degradation. Phosphorylation at Ser-341 also induces ubiquitination and degradation but to a lower extent (By similarity). {ECO:0000250|UniProtKB:O15151}.; PTM: Ubiquitinated and degraded by MDM2. Deubiquitination by USP2 on the other hand stabilizes the MDM4 protein (By similarity). {ECO:0000250|UniProtKB:O15151}.
uniprot
proteins
protein_family
MDM2/MDM4 family
uniprot
proteins
pubmed
10075736
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
8895579
uniprot
proteins
sequence_length
489
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O15151}. Cytoplasm {ECO:0000250|UniProtKB:O15151}.
uniprot
proteins