Spin1
entrez
20729
canonical
uniprot
Q61142
canonical
ensembl
ENSMUSG00000021395
resolver
ensp
ENSMUSP00000093473
resolver
ensp
ENSMUSP00000299292
resolver
ensp
ENSMUSP00000299294
resolver
ensp
ENSMUSP00000299296
resolver
ensp
ENSMUSP00000299307
resolver
ensp
ENSMUSP00000299312
resolver
ensp
ENSMUSP00000299313
resolver
genesymbol
Spin1
resolver
genesymbol_syn
Spin
resolver
uniprot
Q3TLC3
resolver
uniprot
Q3TLF7
resolver
uniprot
Q3UT05
resolver
uniprot
Q91VG8
resolver
uniprot_entry
Q3TLF7_MOUSE
resolver
uniprot_entry
SPIN1_MOUSE
resolver
uniprot_sec
Q3TLC3
resolver
uniprot_sec
Q3UT05
resolver
uniprot_sec
Q91VG8
resolver
amino_acid_sequence
MKTPFGKTPGQRSRADAGHAGVSANMMKKRTSHKKHRTSVGPSKPVSQPRRNIVGCRIQHGWREGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS
uniprot
proteins
function
FUNCTION: Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and 'Lys-9' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis (PubMed:39294378). Plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation (PubMed:39294378). Also recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2 (By similarity). Overexpression induces metaphase arrest and chromosomal instability (PubMed:18543248). Overexpression induces metaphase arrest and chromosomal instability (By similarity). Localizes to active rDNA loci and promotes the expression of rRNA genes (By similarity). May play a role in cell-cycle regulation during the transition from gamete to embryo (PubMed:23894536). Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (PubMed:23894536). {ECO:0000250|UniProtKB:Q9Y657, ECO:0000269|PubMed:18543248, ECO:0000269|PubMed:23894536, ECO:0000269|PubMed:39294378}.
uniprot
proteins
mass_dalton
29643
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during oocyte meiotic maturation. {ECO:0000269|PubMed:9053325}.; PTM: Post-translationally modified during the first mitotic cell cycle.
uniprot
proteins
protein_family
SPIN/STSY family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18543248
uniprot
proteins
pubmed
18645677
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
23894536
uniprot
proteins
pubmed
39294378
uniprot
proteins
pubmed
9053325
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9053325}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9053325}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9Y657}. Note=Associates with the meiotic spindle. {ECO:0000269|PubMed:9053325}.
uniprot
proteins