Tnni3
entrez
21954
canonical
uniprot
P48787
canonical
ensembl
ENSMUSG00000035458
resolver
ensp
ENSMUSP00000096458
resolver
ensp
ENSMUSP00000359915
resolver
enst
ENSMUST00000098859
resolver
genesymbol
Tnni3
resolver
uniprot
Q497F1
resolver
uniprot_entry
Q497F1_MOUSE
resolver
uniprot_entry
TNNI3_MOUSE
resolver
amino_acid_sequence
MADESSDAAGEPQPAPAPVRRRSSANYRAYATEPHAKKKSKISASRKLQLKTLMLQIAKQEMEREAEERRGEKGRVLRTRCQPLELDGLGFEELQDLCRQLHARVDKVDEERYDVEAKVTKNITEIADLTQKIYDLRGKFKRPTLRRVRISADAMMQALLGTRAKESLDLRAHLKQVKKEDIEKENREVGDWRKNIDALSGMEGRKKKFEG
uniprot
proteins
function
FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
uniprot
proteins
mass_dalton
24259
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-32. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T) (By similarity). Phosphorylated at Ser-43 and Ser-45 by PRKCE; phosphorylation increases myocardium contractile dysfunction. {ECO:0000250, ECO:0000269|PubMed:16445938, ECO:0000269|PubMed:17854829}.
uniprot
proteins
protein_family
Troponin I family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16445938
uniprot
proteins
pubmed
17854829
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8195157
uniprot
proteins
pubmed
8276817
uniprot
proteins
sequence_length
211
uniprot
proteins