P0DP29
uniprot
P0DP29
canonical
amino_acid_sequence
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
uniprot
proteins
function
FUNCTION: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (By similarity). Calcium-binding is required for the activation of calmodulin (By similarity). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). Is a regulator of voltage-dependent L-type calcium channels (By similarity). Mediates calcium-dependent inactivation of CACNA1C (By similarity). Positively regulates calcium-activated potassium channel activity of KCNN2 (By similarity). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (By similarity). Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (By similarity). Component of the silencing factor of the integrated stress response (SIFI) complex, a multiprotein complex required to turn off the mitochondrial stress response after a specific stress event has been resolved (By similarity). {ECO:0000250|UniProtKB:P0DP23}.
uniprot
proteins
mass_dalton
16838
uniprot
proteins
post_translational_modification
PTM: Ubiquitination results in a strongly decreased activity. {ECO:0000250}.; PTM: Phosphorylation results in a decreased activity. {ECO:0000269|PubMed:12392717}.
uniprot
proteins
protein_family
Calmodulin family
uniprot
proteins
pubmed
11323678
uniprot
proteins
pubmed
12392717
uniprot
proteins
pubmed
1315919
uniprot
proteins
pubmed
18056528
uniprot
proteins
pubmed
201628
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23109337
uniprot
proteins
pubmed
30021165
uniprot
proteins
pubmed
3035194
uniprot
proteins
pubmed
3145979
uniprot
proteins
pubmed
3990807
uniprot
proteins
pubmed
8576129
uniprot
proteins
sequence_length
149
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P0DP23}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P0DP23}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P0DP23}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:P0DP26}. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. {ECO:0000250|UniProtKB:P0DP23}.
uniprot
proteins