Pcsk7
entrez
18554
canonical
uniprot
Q61139
canonical
ensembl
ENSMUSG00000035382
resolver
ensp
ENSMUSP00000047508
resolver
ensp
ENSMUSP00000150393
resolver
ensp
ENSMUSP00000298898
resolver
enst
ENSMUST00000039059
resolver
enst
ENSMUST00000216672
resolver
genesymbol
Pcsk7
resolver
genesymbol_syn
Pc7
resolver
uniprot
O08577
resolver
uniprot
Q922W4
resolver
uniprot_entry
PCSK7_MOUSE
resolver
uniprot_sec
O08577
resolver
uniprot_sec
Q922W4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by zinc and copper. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MPKGRQKVPHLDAHLGLPICLWLELAIFFLVPQVMGLSEAGGLDILGTGGLSWAVHLDSLEGERKEESLTQQADAVAQAAGLVNAGRIGELQGHYLFVQPTGHRQAMEVEAMRQQAEAVLARHEAVRWHSEQTLLKRAKRSIHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTVQDIAPNYSPEGSYDLNSNDPDPMPHPDEENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVMAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTAIQYEDHHADWLTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPMLKENKAVPRSPHSLEVLWNVSRTDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNAWTFSTVRCWGERARGVYRLVIRDVGDEPLQMGILQQWQLTLYGSMWSPVDIKDRQSLLESAMSGKYLHDGFTLPCPPGLKIPEEDGYTITPNTLKTLVLVGCFSVFWTIYYMLEVCLSQRNKASTHGCRKGCCPWAPRRQNSKDAGTALESMPLCSSKDLDGVDSEHGDCTTASSFLAPELDCPPHQPPDLLQGKSGQIC
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.
uniprot
proteins
mass_dalton
84358
uniprot
proteins
protein_family
Peptidase S8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
8698813
uniprot
proteins
sequence_length
770
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Seems to be localized intracellularly to the trans Golgi network. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 667..687; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins