Mtarc2
entrez
171451
canonical
uniprot
O88994
canonical
ensembl
ENSRNOG00000077900
resolver
ensembl
ENSRNOG00060006953
resolver
ensembl
ENSRNOG00065017179
resolver
ensp
ENSRNOP00000104954
resolver
ensp
ENSRNOP00060008520
resolver
ensp
ENSRNOP00065022697
resolver
enst
ENSRNOT00000149208
resolver
enst
ENSRNOT00060011396
resolver
enst
ENSRNOT00065028650
resolver
genesymbol
Mtarc2
resolver
genesymbol_syn
Marc2
resolver
genesymbol_syn
Mg87
resolver
genesymbol_syn
Mosc2
resolver
uniprot
A0ABK0LH54
resolver
uniprot_entry
A0ABK0LH54_RAT
resolver
uniprot_entry
MARC2_RAT
resolver
amino_acid_sequence
MGSSSSTALARLGLPGQPRSTWLGVAALGLAAVALGTVAWRRARPRRRRQLQQVGTVSKVWIYPIKSCKGVSVCETECTDMGLRCGKVRDRFWMVVKEDGHMITARQEPRLVLVTITLENNYLMLEAPGMEPIVLPIKLPSSNKIHDCRLFGLDIKGRDCGDEVARWFTSYLKTQAYRLVQFDTKMKGRTTKKLYPSESYLQNYEVAYPDCSPIHLISEASLVDLNTRLQKKVKMEYFRPNIVVSGCEAFEEDTWDELLIGDVEMKRVLSCPRCVLTTVDPDTGIIDRKEPLETLKSYRLCDPSVKSLYQSSPLFGMYFSVEKIGSLRVGDPVYRMVD
uniprot
proteins
ec_number
1.7.-.-
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction. {ECO:0000250|UniProtKB:Q969Z3}.
uniprot
proteins
mass_dalton
38248
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. {ECO:0000250|UniProtKB:Q969Z3}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Peroxisome {ECO:0000250}.
uniprot
proteins