Calcoco2
entrez
76815
canonical
uniprot
A2A6M5
canonical
ensembl
ENSMUSG00000006056
resolver
ensp
ENSMUSP00000087407
resolver
genesymbol
Calcoco2
resolver
genesymbol_syn
Ndp52
resolver
genesymbol_syn
Ndp52l1
resolver
uniprot
Q3TK36
resolver
uniprot
Q3TKZ6
resolver
uniprot
Q3TL30
resolver
uniprot
Q9CWE3
resolver
uniprot_entry
CACO2_MOUSE
resolver
uniprot_sec
Q3TK36
resolver
uniprot_sec
Q3TKZ6
resolver
uniprot_sec
Q3TL30
resolver
uniprot_sec
Q9CWE3
resolver
amino_acid_sequence
MDQCPIPTLLEHGNFSQVLFNNVEKFYAPRGDIMCYYTLTEKFIPRRKDWIGIFKVGWKTTQEYYTFMWAPLPKDQNKDSATQQEIQFKAYYLPKDVERYQFCYVDEDGLVRGTSVPFQFCPDPDEDIMVVINKEKVEEMEQLSEELYQQNQELKDKYADLHEQLQRKQVALEATQRVNKTLEHKVEEKASWEKEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEKEKASWEEEKASWEKEKAPWEVEKAPWKEVKAYWWNDLHR
uniprot
proteins
function
FUNCTION: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity). Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (By similarity). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (By similarity). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity). {ECO:0000250|UniProtKB:Q13137}.
uniprot
proteins
mass_dalton
40136
uniprot
proteins
protein_family
CALCOCO family
uniprot
proteins
pubmed
12620990
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q13137}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q13137}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q13137}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins