CLEC12B
entrez
387837
canonical
uniprot
Q2HXU8
canonical
ensembl
ENSG00000256660
resolver
ensp
ENSP00000344563
resolver
ensp
ENSP00000379759
resolver
ensp
ENSP00000767565
resolver
ensp
ENSP00000767567
resolver
genesymbol
CLEC12B
resolver
hgnc
HGNC:31966
resolver
uniprot
A0A140VK10
resolver
uniprot
Q6UWF2
resolver
uniprot
Q6ZRG0
resolver
uniprot_entry
A0A140VK10_HUMAN
resolver
uniprot_entry
CL12B_HUMAN
resolver
uniprot_sec
Q6UWF2
resolver
uniprot_sec
Q6ZRG0
resolver
amino_acid_sequence
MSEEVTYATLTFQDSAGARNNRDGNNLRKRGHPAPSPIWRHAALGLVTLCLMLLIGLVTLGMMFLQISNDINSDSEKLSQLQKTIQQQQDNLSQQLGNSNNLSMEEEFLKSQISSVLKRQEQMAIKLCQELIIHTSDHRCNPCPKMWQWYQNSCYYFTTNEEKTWANSRKDCIDKNSTLVKIDSLEEKDFLMSQPLLMFSFFWLGLSWDSSGRSWFWEDGSVPSPSLFSTKELDQINGSKGCAYFQKGNIYISRCSAEIFWICEKTAAPVKTEDLD
uniprot
proteins
function
FUNCTION: Inhibitory receptor postulated to negatively regulate immune and non-immune functions (PubMed:17562706, PubMed:34310951). Upon phosphorylation, recruits SH2 domain-containing PTPN6 and PTPN11 phosphatases to its ITIM motif and antagonizes activation signals (PubMed:17562706, PubMed:34310951). Although it inhibits KLRK1/NKG2D-mediated signaling, it does not bind known ligands of KLRK1/NKG2D and therefore is not its inhibitory counterpart (PubMed:17562706). May limit activation of myeloid cell subsets in response to infection or tissue inflammation (PubMed:17562706). May protect target cells against natural killer cell-mediated lysis (PubMed:17562706). May negatively regulate cell cycle and differentiation of melanocytes via inactivation of STAT3 (PubMed:34310951). Plays an important function in the skin immunity by modulating melanocytes immune function through the phosphorylation of its ITIM domain. Mechanistically, senses exogenous ligands present on S. aureus and E. coli but not gut Listeria monocytogenes and modulates the IFNgamma-induced production of chemokines and subsequent chemoattraction of immune cells through the STAT1/IRF1/CXCL9 axis (PubMed:39736308). {ECO:0000269|PubMed:17562706, ECO:0000269|PubMed:34310951, ECO:0000269|PubMed:39736308}.
uniprot
proteins
mass_dalton
31616
uniprot
proteins
mutagenesis
MUTAGEN 7; /note="Y->F: Abolishes tyrosine phosphorylation and inhibitory receptor activity. Abolishes interaction with PTPN6 and PTPN11. Abolishes protection against natural killer cell-mediated cytotoxicity."; /evidence="ECO:0000269|PubMed:17562706, ECO:0000269|PubMed:34310951
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:34310951}.
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
17562706
uniprot
proteins
pubmed
34310951
uniprot
proteins
pubmed
39736308
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17562706}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..64; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins