Ccnd3
entrez
25193
canonical
uniprot
P48961
canonical
ensembl
ENSRNOG00000050258
resolver
ensp
ENSRNOP00000064704
resolver
enst
ENSRNOT00000074217
resolver
genesymbol
Ccnd3
resolver
uniprot
M0R5N2
resolver
uniprot
Q5U321
resolver
uniprot
Q63628
resolver
uniprot_entry
CCND3_RAT
resolver
uniprot_entry
M0R5N2_RAT
resolver
uniprot_entry
Q5U321_RAT
resolver
uniprot_sec
Q63628
resolver
amino_acid_sequence
MELLCCEGTRLAPRAGPDPRLLGDQRVLQSLLRLEERYVPRGSYFQCVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAMAPWQLREWEVLVLGKLKWDLAAVIAHDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACSMSADELTELLAGITGTEVDCLRACQEQQIEAALRESLREAAQTAPSPVPKAPGGSSSQGPSQTSTPTDVTAIHL
uniprot
proteins
function
FUNCTION: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Shows transcriptional coactivator activity with ATF5 independently of CDK4. {ECO:0000250|UniProtKB:P30281}.
uniprot
proteins
mass_dalton
32434
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-284 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex. {ECO:0000250|UniProtKB:P24385}.; PTM: Ubiquitinated by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation: ubiquitination is dependent on Thr-284 phosphorylation. The DCX(AMBRA1) complex represents the major regulator of CCND3 stability during the G1/S transition (By similarity). Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:P30281, ECO:0000250|UniProtKB:P30282}.
uniprot
proteins
protein_family
Cyclin D subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7926809
uniprot
proteins
pubmed
8973324
uniprot
proteins
sequence_length
293
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P30281}. Cytoplasm {ECO:0000250|UniProtKB:P30281}.
uniprot
proteins