SULT1E1
entrez
6783
canonical
uniprot
P49888
canonical
ensembl
ENSG00000109193
resolver
ensp
ENSP00000226444
resolver
ensp
ENSP00000574271
resolver
ensp
ENSP00000574272
resolver
ensp
ENSP00000574273
resolver
ensp
ENSP00000574274
resolver
ensp
ENSP00000574275
resolver
ensp
ENSP00000574276
resolver
ensp
ENSP00000574277
resolver
ensp
ENSP00000574278
resolver
ensp
ENSP00000574279
resolver
ensp
ENSP00000574280
resolver
ensp
ENSP00000658630
resolver
enst
ENST00000226444
resolver
enst
ENST00000904212
resolver
enst
ENST00000904213
resolver
enst
ENST00000904214
resolver
enst
ENST00000904215
resolver
enst
ENST00000904216
resolver
enst
ENST00000904217
resolver
enst
ENST00000904218
resolver
enst
ENST00000904219
resolver
enst
ENST00000904220
resolver
enst
ENST00000904221
resolver
genesymbol
SULT1E1
resolver
genesymbol_syn
STE
resolver
hgnc
HGNC:11377
resolver
uniprot
Q53X91
resolver
uniprot
Q8N6X5
resolver
uniprot_entry
Q53X91_HUMAN
resolver
uniprot_entry
ST1E1_HUMAN
resolver
uniprot_sec
Q8N6X5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by estradiol. {ECO:0000269|PubMed:11006110}.
uniprot
proteins
amino_acid_sequence
MNSELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCKEDVIFNRIPFLECRKENLMNGVKQLDEMNSPRIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQVPYGSWYKHVKSWWEKGKSPRVLFLFYEDLKEDIRKEVIKLIHFLERKPSEELVDRIIHHTSFQEMKNNPSTNYTTLPDEIMNQKLSPFMRKGITGDWKNHFTVALNEKFDKHYEQQMKESTLKFRTEI
uniprot
proteins
ec_number
2.8.2.4
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:11006110, PubMed:11884392, PubMed:7779757). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency (PubMed:11006110, PubMed:19589875). Does not sulfonate cortisol, testosterone and dopamine (PubMed:11006110, PubMed:7779757). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. {ECO:0000269|PubMed:11006110, ECO:0000269|PubMed:11884392, ECO:0000269|PubMed:19589875, ECO:0000269|PubMed:35165440, ECO:0000269|PubMed:7779757}.
uniprot
proteins
mass_dalton
35126
uniprot
proteins
mutagenesis
MUTAGEN 85; /note="K->A: Does not have decreased sulfonation activity towards the estrogens and DHEA."; /evidence="ECO:0000269|PubMed:11006110"; MUTAGEN 107; /note="H->A: Complete loss of sulfonation activity towards all substrates tested."; /evidence="ECO:0000269|PubMed:11006110"; MUTAGEN 137; /note="S->A: Decreased gradually the sulfotransferase activity."; /evidence="ECO:0000269|PubMed:11884392"; MUTAGEN 137; /note="S->C: Decreased gradually the sulfotransferase activity."; /evidence="ECO:0000269|PubMed:11884392"; MUTAGEN 145; /note="V->E: Substrate specificity constants for estradiol and estrone are reduced. Dramatic 400-fold increase in the ability to sulfonate dopamine."; /evidence="ECO:0000269|PubMed:11006110"; MUTAGEN 269; /note="V->E: Does not prevent the formation of homodimer."; /evidence="ECO:0000269|PubMed:11884392
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
10541560
uniprot
proteins
pubmed
11006110
uniprot
proteins
pubmed
11884392
uniprot
proteins
pubmed
12782487
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19589875
uniprot
proteins
pubmed
35165440
uniprot
proteins
pubmed
7779757
uniprot
proteins
pubmed
8185618
uniprot
proteins
pubmed
8530066
uniprot
proteins
sequence_length
294
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11006110}.
uniprot
proteins