Rbpj
entrez
19664
canonical
uniprot
P31266
canonical
ensembl
ENSMUSG00000039191
resolver
ensp
ENSMUSP00000040694
resolver
ensp
ENSMUSP00000084618
resolver
ensp
ENSMUSP00000109496
resolver
ensp
ENSMUSP00000143846
resolver
ensp
ENSMUSP00000143866
resolver
ensp
ENSMUSP00000231899
resolver
enst
ENSMUST00000087360
resolver
enst
ENSMUST00000201883
resolver
enst
ENSMUST00000201912
resolver
genesymbol
Rbpj
resolver
genesymbol_syn
Igkjrb1
resolver
genesymbol_syn
Igkrsbp
resolver
genesymbol_syn
Rbpsuh
resolver
uniprot
A0A0J9YTT9
resolver
uniprot
A0A0J9YTV5
resolver
uniprot
E9Q7W0
resolver
uniprot
Q3U6F1
resolver
uniprot
Q3UM17
resolver
uniprot
Q80UN8
resolver
uniprot
Q8C4Z3
resolver
uniprot_entry
A0A0J9YTT9_MOUSE
resolver
uniprot_entry
A0A0J9YTV5_MOUSE
resolver
uniprot_entry
E9Q7W0_MOUSE
resolver
uniprot_entry
Q3U6F1_MOUSE
resolver
uniprot_entry
Q3UM17_MOUSE
resolver
uniprot_entry
SUH_MOUSE
resolver
uniprot_sec
Q80UN8
resolver
uniprot_sec
Q8C4Z3
resolver
amino_acid_sequence
MPSGFPQSPRTSPRARPKTRITGALPMDYSEGLSAEERPAHAPSAGKFGERPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFYIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDGASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGVIYSTSLTFTYTPEPGPRPHCSAAGAILRANSSQVPSNESNTNSEGNYTNASTNSTSVTSSTATVVS
uniprot
proteins
function
FUNCTION: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations (PubMed:7566092). Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes (By similarity) (PubMed:18381292). Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (PubMed:26194095). {ECO:0000250|UniProtKB:P28159, ECO:0000250|UniProtKB:Q06330, ECO:0000269|PubMed:18381292, ECO:0000269|PubMed:26194095, ECO:0000269|PubMed:7566092}.
uniprot
proteins
mass_dalton
58537
uniprot
proteins
mutagenesis
MUTAGEN 128; /note="F->R: No effect on interaction with L3MBTL3."; /evidence="ECO:0000269|PubMed:29030483"; MUTAGEN 172; /note="F->R: No effect on interaction with L3MBTL3."; /evidence="ECO:0000269|PubMed:29030483"; MUTAGEN 186; /note="R->E: No effect on interaction with L3MBTL3."; /evidence="ECO:0000269|PubMed:29030483"; MUTAGEN 261; /note="F->R: Loss of interaction with L3MBTL3."; /evidence="ECO:0000269|PubMed:29030483"; MUTAGEN 263; /note="V->R: Decreased interaction with L3MBTL3."; /evidence="ECO:0000269|PubMed:29030483"; MUTAGEN 284; /note="A->R: Decreased interaction with L3MBTL3."; /evidence="ECO:0000269|PubMed:29030483"; MUTAGEN 333; /note="Q->R: No effect on interaction with L3MBTL3."; /evidence="ECO:0000269|PubMed:29030483"; MUTAGEN 389; /note="N->R: No effect on interaction with L3MBTL3."; /evidence="ECO:0000269|PubMed:29030483"; MUTAGEN 398; /note="E->R: No effect on interaction with L3MBTL3."; /evidence="ECO:0000269|PubMed:29030483"; MUTAGEN 407; /note="N->R: No effect on interaction with L3MBTL3."; /evidence="ECO:0000269|PubMed:29030483"; MUTAGEN 422; /note="R->E: No effect on interaction with L3MBTL3."; /evidence="ECO:0000269|PubMed:29030483"; MUTAGEN 425; /note="E->R: No effect on interaction with L3MBTL3."; /evidence="ECO:0000269|PubMed:29030483
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF(FBXO42) complex at Lys-201; leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q06330}.
uniprot
proteins
protein_family
Su(H) family
uniprot
proteins
pubmed
10640276
uniprot
proteins
pubmed
11318877
uniprot
proteins
pubmed
11604511
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17283045
uniprot
proteins
pubmed
1740450
uniprot
proteins
pubmed
18381292
uniprot
proteins
pubmed
1950768
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
2556644
uniprot
proteins
pubmed
25875095
uniprot
proteins
pubmed
26194095
uniprot
proteins
pubmed
29030483
uniprot
proteins
pubmed
7566092
uniprot
proteins
pubmed
9418910
uniprot
proteins
sequence_length
526
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}. Note=Mainly nuclear, upon interaction with RITA1, translocates to the cytoplasm, down-regulating the Notch signaling pathway. {ECO:0000250}.
uniprot
proteins