Prkab2
entrez
64562
canonical
uniprot
Q9QZH4
canonical
ensembl
ENSRNOG00000018166
resolver
ensp
ENSRNOP00000102840
resolver
ensp
ENSRNOP00000111047
resolver
enst
ENSRNOT00000124604
resolver
enst
ENSRNOT00000128124
resolver
genesymbol
Prkab2
resolver
uniprot
A0ABK0LN81
resolver
uniprot
A0ABK0LZA4
resolver
uniprot_entry
A0ABK0LN81_RAT
resolver
uniprot_entry
A0ABK0LZA4_RAT
resolver
uniprot_entry
AAKB2_RAT
resolver
amino_acid_sequence
MGNTTSERVSGERHGAKAARAEGGGHGPGKEHKIMVGSTDDPSVFSLPDSKLPGDKEFVPWQQDLDDSVKPTQQARPTVIRWSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPEGEHQYKFFVDGQWVHDPSEPVVTSQLGTINNLIHVKKSDFEVFDALKLDSMESSETSCRDLSSSPPGPYGQEMYVFRSEERFKSPPILPPHLLQVILNKDTNISCDPALLPEPNHVMLNHLYALSTKDSVMVLSATHRYKKKYVTTLLYKPI
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
30227
uniprot
proteins
post_translational_modification
PTM: Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK. {ECO:0000269|PubMed:10544261, ECO:0000269|PubMed:21460634}.
uniprot
proteins
protein_family
5'-AMP-activated protein kinase beta subunit family
uniprot
proteins
pubmed
10544261
uniprot
proteins
pubmed
21460634
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
271
uniprot
proteins