ABHD17C
entrez
58489
canonical
uniprot
Q6PCB6
canonical
ensembl
ENSG00000136379
resolver
ensp
ENSP00000258884
resolver
genesymbol
ABHD17C
resolver
genesymbol_syn
FAM108C1
resolver
hgnc
HGNC:26925
resolver
uniprot
Q1RMD6
resolver
uniprot
Q9NPM1
resolver
uniprot_entry
AB17C_HUMAN
resolver
uniprot_sec
Q1RMD6
resolver
uniprot_sec
Q9NPM1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by palmostatin-B. {ECO:0000269|PubMed:26701913}.
uniprot
proteins
amino_acid_sequence
MPEPGPRMNGFSLGELCWLFCCPPCPSRIAAKLAFLPPEPTYTVLAPEQRGAGASAPAPAQATAAAAAAQPAPQQPEEGAGAGPGACSLHLSERADWQYSQRELDAVEVFFSRTARDNRLGCMFVRCAPSSRYTLLFSHGNAVDLGQMCSFYIGLGSRINCNIFSYDYSGYGVSSGKPSEKNLYADIDAAWQALRTRYGVSPENIILYGQSIGTVPTVDLASRYECAAVILHSPLMSGLRVAFPDTRKTYCFDAFPSIDKISKVTSPVLVIHGTEDEVIDFSHGLAMYERCPRAVEPLWVEGAGHNDIELYAQYLERLKQFISHELPNS
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
function
FUNCTION: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95. {ECO:0000269|PubMed:26701913}.
uniprot
proteins
mass_dalton
35831
uniprot
proteins
post_translational_modification
PTM: Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95. {ECO:0000250|UniProtKB:Q7M759}.
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
ABHD17 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26701913
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:B5DFK7}; Lipid-anchor {ECO:0000250|UniProtKB:B5DFK7}; Cytoplasmic side {ECO:0000250|UniProtKB:B5DFK7}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:B5DFK7}. Postsynaptic density membrane {ECO:0000250|UniProtKB:B5DFK7}.
uniprot
proteins