BCL3
entrez
602
canonical
uniprot
P20749
canonical
ensembl
ENSG00000069399
resolver
ensp
ENSP00000164227
resolver
enst
ENST00000164227
resolver
genesymbol
BCL3
resolver
genesymbol_syn
BCL4
resolver
genesymbol_syn
D19S37
resolver
hgnc
HGNC:998
resolver
uniprot
B7Z3N9
resolver
uniprot_entry
B7Z3N9_HUMAN
resolver
uniprot_entry
BCL3_HUMAN
resolver
amino_acid_sequence
MPRCPAGAMDEGPVDLRTRPKAAGLPGAALPLRKRPLRAPSPEPAAPRGAAGLVVPLDPLRGGCDLPAVPGPPHGLARPEALYYPGALLPLYPTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPNFFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions. {ECO:0000269|PubMed:2180580, ECO:0000269|PubMed:7896265}.
uniprot
proteins
function
FUNCTION: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {ECO:0000250, ECO:0000269|PubMed:8453667}.
uniprot
proteins
mass_dalton
47584
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation (By similarity). {ECO:0000250}.; PTM: Activated by phosphorylation. {ECO:0000269|PubMed:15469820}.
uniprot
proteins
pubmed
10362352
uniprot
proteins
pubmed
10469655
uniprot
proteins
pubmed
11707390
uniprot
proteins
pubmed
12730195
uniprot
proteins
pubmed
15469820
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2180580
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
7896265
uniprot
proteins
pubmed
8453667
uniprot
proteins
sequence_length
454
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. {ECO:0000250}.
uniprot
proteins