Gabra4
entrez
14397
canonical
uniprot
Q9D6F4
canonical
ensembl
ENSMUSG00000029211
resolver
ensp
ENSMUSP00000031121
resolver
ensp
ENSMUSP00000142466
resolver
ensp
ENSMUSP00000143675
resolver
ensp
ENSMUSP00000184716
resolver
ensp
ENSMUSP00000184719
resolver
ensp
ENSMUSP00000184722
resolver
ensp
ENSMUSP00000184727
resolver
ensp
ENSMUSP00000184729
resolver
enst
ENSMUST00000031121
resolver
enst
ENSMUST00000198138
resolver
enst
ENSMUST00000199357
resolver
genesymbol
Gabra4
resolver
uniprot
A0A0G2JDR1
resolver
uniprot
A0A0G2JGS2
resolver
uniprot
Q3USX9
resolver
uniprot
Q543Z0
resolver
uniprot_entry
A0A0G2JDR1_MOUSE
resolver
uniprot_entry
A0A0G2JGS2_MOUSE
resolver
uniprot_entry
GBRA4_MOUSE
resolver
uniprot_entry
Q3USX9_MOUSE
resolver
uniprot_entry
Q543Z0_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Potentiated by gaboxadol (PubMed:17005728). Potentiated by histamine (By similarity). {ECO:0000250|UniProtKB:P48169, ECO:0000269|PubMed:17005728}.
uniprot
proteins
amino_acid_sequence
MVSVQKVPAIALCSGVSLALLHFLCLAACLNESPGQNSKDEKLCPENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMQKAKKKISKPPPEVPAAPVLKEKHTETSLQNTHANLNMRKRTNALVHSESDVKSRTEVGNHSSKTSAVQESSEATPKAHLASSPNPFSRANAAETMSAAARGLSSAASPSPHGTLRPASLGSASTRPAFGSRLGRIKTTVNTTGAAGNVSATPPPPAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKSESLM
uniprot
proteins
function
FUNCTION: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:17005728). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). Alpha-4/GABRA4 subunit often assembles with delta or gamma-2 subunits, in combination with beta subunits (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:17005728). GABAARs containing alpha-4 are predominantly extrasynaptic, contributing to tonic inhibition in dentate granule cells and thalamic relay neurons (PubMed:17005728). Extrasynaptic alpha-4-containing GABAARs control levels of excitability and network activity (PubMed:17005728). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity). {ECO:0000250|UniProtKB:P48169, ECO:0000269|PubMed:17005728}.
uniprot
proteins
mass_dalton
60878
uniprot
proteins
protein_family
GABRA4 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17005728
uniprot
proteins
sequence_length
552
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17005728}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48169}. Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48169}.
uniprot
proteins
transmembrane_region
TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P48169"; TRANSMEM 285..305; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P48169"; TRANSMEM 319..341; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P48169"; TRANSMEM 516..538; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P48169
uniprot
proteins