Sla
entrez
20491
canonical
uniprot
Q60898
canonical
ensembl
ENSMUSG00000022372
resolver
ensp
ENSMUSP00000127901
resolver
ensp
ENSMUSP00000130222
resolver
ensp
ENSMUSP00000131865
resolver
ensp
ENSMUSP00000363382
resolver
enst
ENSMUST00000168522
resolver
genesymbol
Sla
resolver
genesymbol_syn
Slap
resolver
genesymbol_syn
Slap1
resolver
uniprot
A0A0R4J247
resolver
uniprot
Q4FJX0
resolver
uniprot
Q8C9Q8
resolver
uniprot
Q8CAT0
resolver
uniprot
Q8CBE9
resolver
uniprot
Q8QZX8
resolver
uniprot_entry
A0A0R4J247_MOUSE
resolver
uniprot_entry
Q4FJX0_MOUSE
resolver
uniprot_entry
SLAP1_MOUSE
resolver
uniprot_sec
Q8C9Q8
resolver
uniprot_sec
Q8CAT0
resolver
uniprot_sec
Q8CBE9
resolver
uniprot_sec
Q8QZX8
resolver
amino_acid_sequence
MGNSMKSTSPPSERPLSSSEGLESDFLAVLTDYPSPDISPPIFRRGEKLRVISDEGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKIGSFMIRESETKKGFYSLSVRHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVTHYSEVADGLCCVLTTPCLAQNIPAPTSHPSPCTSPGSPVTLRQKTFDWKRVSRLQEGSEGAENPLRVDESLFSYGLRESIASYLSLTGDDSSSFDRKKKSLSLMYTGSKRKSSFFSAPQYFED
uniprot
proteins
function
FUNCTION: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269|PubMed:10662792, ECO:0000269|PubMed:10779329, ECO:0000269|PubMed:11567635}.
uniprot
proteins
mass_dalton
31681
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Abolishes myristoylation and localization to endosomes."; /evidence="ECO:0000269|PubMed:10779329"; MUTAGEN 73; /note="P->L: Slightly affects inhibitory function. Abolishes inhibitory function; when associated with E-111."; /evidence="ECO:0000269|PubMed:10662792"; MUTAGEN 111; /note="R->E: Abolishes localization to endosomes. Strongly affects inhibitory function. Abolishes inhibitory function; when associated with L-73."; /evidence="ECO:0000269|PubMed:10662792
uniprot
proteins
pubmed
10630289
uniprot
proteins
pubmed
10662792
uniprot
proteins
pubmed
10779329
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
11567635
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7543898
uniprot
proteins
pubmed
9742401
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10779329}. Endosome {ECO:0000269|PubMed:10779329}. Note=Colocalizes with endosomes.
uniprot
proteins