Rfng
entrez
19719
canonical
uniprot
O09009
canonical
ensembl
ENSMUSG00000025158
resolver
ensp
ENSMUSP00000026156
resolver
ensp
ENSMUSP00000242230
resolver
enst
ENSMUST00000026156
resolver
genesymbol
Rfng
resolver
uniprot
B1ATU3
resolver
uniprot_entry
RFNG_MOUSE
resolver
uniprot_sec
B1ATU3
resolver
amino_acid_sequence
MSRARRVLCRACLALAAVLAVLLLLPLPLPLPLPRAPAPDPDRVPTRSLTLEGDRLQPDDVFIAVKTTRKNHGPRLRLLLRTWISRAPRQTFIFTDGDDPELQMLAGGRMINTNCSAVRTRQALCCKMSVEYDKFLESGRKWFCHVDDDNYVNPKSLLHLLSTFSSNQDIYLGRPSLDHPIEATERVQGGGTSNTVKFWFATGGAGFCLSRGLALKMSPWASLGSFMSTAERVRLPDDCTVGYIVEGLLGARLLHSPLFHSHLENLQRLPSGAILQQVTLSYGGPENPHNVVNVAGSFNIQQDPTRFQSVHCLLYPDTHWCPMKNRVEGAFQ
uniprot
proteins
ec_number
2.4.1.222
uniprot
proteins
function
FUNCTION: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1 (PubMed:28089369). May be involved in limb formation and in neurogenesis (By similarity). {ECO:0000250|UniProtKB:O12972, ECO:0000250|UniProtKB:Q9R1U9, ECO:0000269|PubMed:28089369}.
uniprot
proteins
mass_dalton
36926
uniprot
proteins
protein_family
Glycosyltransferase 31 family
uniprot
proteins
pubmed
10341080
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16221665
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
28089369
uniprot
proteins
pubmed
9187150
uniprot
proteins
pubmed
9207795
uniprot
proteins
sequence_length
332
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..29; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins