SPATA2
entrez
9825
canonical
uniprot
Q9UM82
canonical
ensembl
ENSG00000158480
resolver
ensp
ENSP00000289431
resolver
ensp
ENSP00000416799
resolver
ensp
ENSP00000527568
resolver
ensp
ENSP00000527569
resolver
ensp
ENSP00000527570
resolver
ensp
ENSP00000609156
resolver
ensp
ENSP00000609157
resolver
ensp
ENSP00000619456
resolver
enst
ENST00000289431
resolver
enst
ENST00000422556
resolver
enst
ENST00000857509
resolver
enst
ENST00000857510
resolver
enst
ENST00000857511
resolver
enst
ENST00000939097
resolver
enst
ENST00000939098
resolver
enst
ENST00000949397
resolver
genesymbol
SPATA2
resolver
genesymbol_syn
KIAA0757
resolver
genesymbol_syn
PD1
resolver
hgnc
HGNC:14681
resolver
uniprot
A8K0S9
resolver
uniprot
B4DID4
resolver
uniprot
E1P626
resolver
uniprot
O94857
resolver
uniprot_entry
A8K0S9_HUMAN
resolver
uniprot_entry
B4DID4_HUMAN
resolver
uniprot_entry
SPAT2_HUMAN
resolver
uniprot_sec
E1P626
resolver
uniprot_sec
O94857
resolver
amino_acid_sequence
MGKPSSMDTKFKDDLFRKYVQFHESKVDTTTSRQRPGSDECLRVAASTLLSLHKVDPFYRFRLIQFYEVVESSLRSLSSSSLRALHGAFSMLETVGINLFLYPWKKEFRSIKTYTGPFVYYVKSTLLEEDIRAILSCMGYTPELGTAYKLRELVETLQVKMVSFELFLAKVECEQMLEIHSQVKDKGYSELDIVSERKSSAEDVRGCSDALRRRAEGREHLTASMSRVALQKSASERAAKDYYKPRVTKPSRSVDAYDSYWESRKPPLKASLSLRKEPVATDVGDDLKDEIIRPSPSLLTMASSPHGSPDVLPPASPSNGPALLRGTYFSTQDDVDLYTDSEPRATYRRQDALRPDVWLLRNDAHSLYHKRSPPAKESALSKCQSCGLSCSSSLCQRCDSLLTCPPASKPSAFPSKASTHDSLAHGASLREKYPGQTQGLDRLPHLHSKSKPSTTPTSRCGFCNRPGATNTCTQCSKVSCDACLSAYHYDPCYKKSELHKFMPNNQLNYKSTQLSHLVYR
uniprot
proteins
function
FUNCTION: Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity). {ECO:0000250|UniProtKB:Q8K004, ECO:0000269|PubMed:27307491, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27545878, ECO:0000269|PubMed:27591049}.
uniprot
proteins
mass_dalton
58427
uniprot
proteins
mutagenesis
MUTAGEN 94; /note="T->K: Weak or no effect on interaction with CYLD."; /evidence="ECO:0000269|PubMed:27591049"; MUTAGEN 98; /note="N->A: Weak or no effect on interaction with CYLD."; /evidence="ECO:0000269|PubMed:27591049"; MUTAGEN 108; /note="F->A: Abolished interaction with CYLD."; /evidence="ECO:0000269|PubMed:27458237"; MUTAGEN 114; /note="Y->A: Reduced interaction with CYLD."; /evidence="ECO:0000269|PubMed:27591049"; MUTAGEN 115; /note="T->A,N: Reduced interaction with CYLD."; /evidence="ECO:0000269|PubMed:27591049"; MUTAGEN 338; /note="Y->A: Strongly reduced interaction with RNF31/HOIP."; /evidence="ECO:0000269|PubMed:27458237
uniprot
proteins
protein_family
SPATA2 family
uniprot
proteins
pubmed
10222154
uniprot
proteins
pubmed
11079456
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27307491
uniprot
proteins
pubmed
27458237
uniprot
proteins
pubmed
27545878
uniprot
proteins
pubmed
27591049
uniprot
proteins
pubmed
28189684
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
520
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10222154, ECO:0000269|PubMed:11079456}. Nucleus {ECO:0000250|UniProtKB:Q66HP6}. Note=Detected in the tubular compartment of the testis and, in the cytoplasm of the Sertoli cells. {ECO:0000269|PubMed:11079456}.
uniprot
proteins