PRKX
entrez
5613
canonical
uniprot
P51817
canonical
ensembl
ENSG00000183943
resolver
ensp
ENSP00000262848
resolver
ensp
ENSP00000580457
resolver
ensp
ENSP00000623370
resolver
ensp
ENSP00000623372
resolver
enst
ENST00000262848
resolver
enst
ENST00000910398
resolver
enst
ENST00000953311
resolver
enst
ENST00000953313
resolver
genesymbol
PRKX
resolver
genesymbol_syn
PKX1
resolver
hgnc
HGNC:9441
resolver
uniprot_entry
PRKX_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Binding of cAMP to the PRKAR1A or PRKAR1B regulatory subunits induces dissociation of the holoenzyme heterotetramer. The released monomeric PRKX is then active and able to phosphorylate its substrates. {ECO:0000269|PubMed:10026146, ECO:0000269|PubMed:12082174, ECO:0000269|PubMed:20819953}.
uniprot
proteins
amino_acid_sequence
MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. {ECO:0000269|PubMed:12082174, ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:17980165, ECO:0000269|PubMed:19367327, ECO:0000269|PubMed:21684272, ECO:0000269|PubMed:9860982}.
uniprot
proteins
mass_dalton
40896
uniprot
proteins
mutagenesis
MUTAGEN 78; /note="K->R: Loss of function."; /evidence="ECO:0000269|PubMed:12082174"; MUTAGEN 93; /note="H->Q: Constitutive kinase activity; when associated with R-202."; /evidence="ECO:0000269|PubMed:16236808"; MUTAGEN 202; /note="W->R: Constitutive kinase activity; when associated with Q-93."; /evidence="ECO:0000269|PubMed:16236808"; MUTAGEN 283; /note="R->L: Increases the affinity for PRKAR2A and PRKAR2B."; /evidence="ECO:0000269|PubMed:20819953
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; autophosphorylates in vitro.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
cAMP subfamily
uniprot
proteins
pubmed
10026146
uniprot
proteins
pubmed
12082174
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15879576
uniprot
proteins
pubmed
16236808
uniprot
proteins
pubmed
16491121
uniprot
proteins
pubmed
17980165
uniprot
proteins
pubmed
19367327
uniprot
proteins
pubmed
20819953
uniprot
proteins
pubmed
21684272
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
7633447
uniprot
proteins
pubmed
9302280
uniprot
proteins
pubmed
9860982
uniprot
proteins
sequence_length
358
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation.
uniprot
proteins