Sh3rf1
entrez
59009
canonical
uniprot
Q69ZI1
canonical
ensembl
ENSMUSG00000031642
resolver
ensp
ENSMUSP00000034060
resolver
ensp
ENSMUSP00000148118
resolver
enst
ENSMUST00000034060
resolver
genesymbol
Sh3rf1
resolver
genesymbol_syn
Kiaa1494
resolver
genesymbol_syn
Posh
resolver
genesymbol_syn
Posh1
resolver
genesymbol_syn
Sh3md2
resolver
uniprot
E9QQ33
resolver
uniprot
O70254
resolver
uniprot
Q3UG42
resolver
uniprot
Q6P9M8
resolver
uniprot
Q8BR66
resolver
uniprot
Q8C2T5
resolver
uniprot_entry
E9QQ33_MOUSE
resolver
uniprot_entry
SH3R1_MOUSE
resolver
uniprot_sec
O70254
resolver
uniprot_sec
Q3UG42
resolver
uniprot_sec
Q6P9M8
resolver
uniprot_sec
Q8BR66
resolver
uniprot_sec
Q8C2T5
resolver
amino_acid_sequence
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVDELPSNILLVRLLDGIKQRPWKPGPGGGGGTTCTNTLRAQGSTVVNCGSKDLQSSQCGQQPRVQAWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVSGVHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPPVPGVDTAECPSATAQSTSASKHPDTKKNTRKRHSFTSLTMANKSSQGSQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPAFTFPSDVPYQAALGSMNPPLPPPPLLAATVLASTPSGATAAVAAAAAAAAAAGMGPRPVMGSSEQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWYKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVSMSTAGQASRGVTMVSPSTAGGPTQKPQGNGVAGNPSVVPTAVVSAAHIQTSPQAKVLLHMSGQMTVNQARNAVRTVAAHSQERPTAAVTPIQVQNAACLGPASVGLPHHSLASQPLPPMAGPAAHGAAVSISRTNAPMACAAGASLASPNMTSAMLETEPSGRTVTILPGLPTSPESAASACGNSSAGKPDKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTLDVELGAGEAPLQGAVGPELPLGGSHGRVGSCPTDGDGPVAAGTAALAQDAFHRKTSSLDSAVPIAPPPRQACSSLGPVMNEARPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing its dynamin-dependent and clathrin-independent endocytosis (By similarity). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells (PubMed:23963642, PubMed:27084103, PubMed:9482736). Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (PubMed:22959435). {ECO:0000250|UniProtKB:Q7Z6J0, ECO:0000269|PubMed:22959435, ECO:0000269|PubMed:23963642, ECO:0000269|PubMed:27084103, ECO:0000269|PubMed:9482736}.
uniprot
proteins
mass_dalton
93447
uniprot
proteins
mutagenesis
MUTAGEN 470; /note="E->Q: Loss of binding to AKT2."; /evidence="ECO:0000269|PubMed:14504284"; MUTAGEN 489; /note="W->A: Loss of binding to AKT2 and enhanced binding to MAP3K11."; /evidence="ECO:0000269|PubMed:14504284
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-304 by AKT1 and AKT2. When phosphorylated, it has reduced ability to bind Rac. {ECO:0000250|UniProtKB:Q7Z6J0}.; PTM: Autoubiquitinated. Ubiquitinated by SH3RF2, leading to proteasome-mediated degradation. {ECO:0000250|UniProtKB:Q71F54}.
uniprot
proteins
protein_family
SH3RF family
uniprot
proteins
pubmed
12514131
uniprot
proteins
pubmed
14504284
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16230351
uniprot
proteins
pubmed
16571722
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22959435
uniprot
proteins
pubmed
23963642
uniprot
proteins
pubmed
27084103
uniprot
proteins
pubmed
9482736
uniprot
proteins
sequence_length
892
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q71F54}. Cell projection, lamellipodium {ECO:0000269|PubMed:14504284, ECO:0000269|PubMed:22959435}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:14504284}. Note=Colocalizes, with AKT2 in lamellipodia. Colocalizes, with HERP1, in trans-Golgi network (By similarity). {ECO:0000250|UniProtKB:Q7Z6J0, ECO:0000269|PubMed:14504284}.
uniprot
proteins