Pafah1b1
entrez
18472
canonical
uniprot
P63005
canonical
ensembl
ENSMUSG00000020745
resolver
ensp
ENSMUSP00000021091
resolver
genesymbol
Pafah1b1
resolver
genesymbol_syn
LIS1
resolver
genesymbol_syn
Lis-1
resolver
genesymbol_syn
Lis1
resolver
genesymbol_syn
PAFAH1B1
resolver
genesymbol_syn
Pafaha
resolver
uniprot
O35592
resolver
uniprot
P43035
resolver
uniprot
P81692
resolver
uniprot
Q5SW18
resolver
uniprot
Q9R2A6
resolver
uniprot_entry
LIS1_MOUSE
resolver
uniprot_entry
Q5SW18_MOUSE
resolver
uniprot_sec
O35592
resolver
uniprot_sec
P43035
resolver
uniprot_sec
P81692
resolver
uniprot_sec
Q9R2A6
resolver
amino_acid_sequence
MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR
uniprot
proteins
function
FUNCTION: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (By similarity). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (PubMed:17330141). {ECO:0000250|UniProtKB:P43033, ECO:0000250|UniProtKB:P43034, ECO:0000255|HAMAP-Rule:MF_03141, ECO:0000269|PubMed:11056530, ECO:0000269|PubMed:11344260, ECO:0000269|PubMed:12796778, ECO:0000269|PubMed:12911752, ECO:0000269|PubMed:14507966, ECO:0000269|PubMed:14578885, ECO:0000269|PubMed:14691133, ECO:0000269|PubMed:15173193, ECO:0000269|PubMed:15473966, ECO:0000269|PubMed:16107726, ECO:0000269|PubMed:16203747, ECO:0000269|PubMed:16369480, ECO:0000269|PubMed:16481446, ECO:0000269|PubMed:17330141}.
uniprot
proteins
mass_dalton
46670
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="I->R: Impairs self-association and reduces protein stability."; /evidence="ECO:0000269|PubMed:16258276"; MUTAGEN 19; /note="L->R: Impairs self-association, reduces protein stability and promotes localization to actin fibers."; /evidence="ECO:0000269|PubMed:16258276"; MUTAGEN 31; /note="F->S: Abrogates interaction with NDLE1, NUDC, PAFAH1B3 and RSN. Also impairs localization to centrosomes and microtubule plus ends. Reduces protein stability."; /evidence="ECO:0000269|PubMed:12885786"; MUTAGEN 149; /note="H->R: Abrogates self-association and interaction with DAB1, dynein, NDEL1, PAFAH1B3 and RSN. Also impairs localization to centrosomes and microtubule plus ends. Reduces protein stability."; /evidence="ECO:0000269|PubMed:11163259, ECO:0000269|PubMed:11231056, ECO:0000269|PubMed:12885786, ECO:0000269|PubMed:14578885"; MUTAGEN 152; /note="S->W: Abrogates interaction with NDEL1."; /evidence="ECO:0000269|PubMed:11231056"; MUTAGEN 162; /note="G->S: Abrogates interaction with PAFAH1B3 and RSN. Also impairs localization to centrosomes and microtubule plus ends. Reduces protein stability."; /evidence="ECO:0000269|PubMed:12885786"; MUTAGEN 169; /note="S->P: Abrogates interaction with NDEL1, PAFAH1B3 and RSN. Also impairs localization to centrosomes and microtubule plus ends. Reduces protein stability."; /evidence="ECO:0000269|PubMed:11231056, ECO:0000269|PubMed:12885786"; MUTAGEN 238; /note="R->A: Abrogates interaction with PAFAH1B2."; /evidence="ECO:0000269|PubMed:15572112"; MUTAGEN 317; /note="D->H: Abrogates interaction with NDEL1, PAFAH1B3 and RSN. Also impairs localization to centrosomes and microtubule plus ends. Reduces protein stability."; /evidence="ECO:0000269|PubMed:12885786
uniprot
proteins
protein_family
WD repeat LIS1/nudF family
uniprot
proteins
pubmed
11001923
uniprot
proteins
pubmed
11056530
uniprot
proteins
pubmed
11163258
uniprot
proteins
pubmed
11163259
uniprot
proteins
pubmed
11163260
uniprot
proteins
pubmed
11231056
uniprot
proteins
pubmed
11344260
uniprot
proteins
pubmed
11756344
uniprot
proteins
pubmed
11940666
uniprot
proteins
pubmed
12551946
uniprot
proteins
pubmed
12796778
uniprot
proteins
pubmed
12885786
uniprot
proteins
pubmed
12911752
uniprot
proteins
pubmed
12950100
uniprot
proteins
pubmed
14507966
uniprot
proteins
pubmed
14578885
uniprot
proteins
pubmed
14691133
uniprot
proteins
pubmed
15147871
uniprot
proteins
pubmed
15173193
uniprot
proteins
pubmed
15274919
uniprot
proteins
pubmed
15473966
uniprot
proteins
pubmed
15473967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15572112
uniprot
proteins
pubmed
15939891
uniprot
proteins
pubmed
16107726
uniprot
proteins
pubmed
16203747
uniprot
proteins
pubmed
16258276
uniprot
proteins
pubmed
16291865
uniprot
proteins
pubmed
16369480
uniprot
proteins
pubmed
16481446
uniprot
proteins
pubmed
17330141
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23097494
uniprot
proteins
pubmed
7751941
uniprot
proteins
pubmed
7821822
uniprot
proteins
pubmed
9479492
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus membrane {ECO:0000255|HAMAP-Rule:MF_03141}. Note=May localize to the nuclear membrane (By similarity). Localizes to the plus end of microtubules and to the centrosome. Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes. {ECO:0000250}.
uniprot
proteins