SENP1
entrez
29843
canonical
uniprot
Q9P0U3
canonical
ensembl
ENSG00000079387
resolver
ensp
ENSP00000394791
resolver
ensp
ENSP00000447328
resolver
ensp
ENSP00000604633
resolver
ensp
ENSP00000604637
resolver
ensp
ENSP00000737044
resolver
ensp
ENSP00000737046
resolver
genesymbol
SENP1
resolver
hgnc
HGNC:17927
resolver
uniprot
A8K7P5
resolver
uniprot
Q86XC8
resolver
uniprot_entry
SENP1_HUMAN
resolver
uniprot_sec
A8K7P5
resolver
uniprot_sec
Q86XC8
resolver
amino_acid_sequence
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
function
FUNCTION: Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15487983). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15199155, PubMed:16253240, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:15199155, PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (PubMed:29506078, PubMed:34048572, PubMed:37257451). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844). {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:15487983, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374, ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:37257451}.
uniprot
proteins
mass_dalton
73481
uniprot
proteins
mutagenesis
MUTAGEN 441; /note="D->A: No effect on SUMO2 processing and SUMO2 deconjugating activities."; /evidence="ECO:0000269|PubMed:16553580"; MUTAGEN 465; /note="W->A: Impairs SUMO2 processing and SUMO2 deconjugating activities."; /evidence="ECO:0000269|PubMed:16553580"; MUTAGEN 468; /note="D->A: Slightly impairs SUMO2 processing activity. No effect on SUMO2 deconjugating activity."; /evidence="ECO:0000269|PubMed:16553580"; MUTAGEN 496; /note="F->A: Impairs SUMO2 processing activity. No effect on SUMO2 deconjugating activity."; /evidence="ECO:0000269|PubMed:16553580"; MUTAGEN 511; /note="R->A: Impairs SUMO2 processing activity. No effect on SUMO2 deconjugating activity."; /evidence="ECO:0000269|PubMed:16553580"; MUTAGEN 512; /note="W->A: Impairs SUMO2 processing and SUMO2 deconjugating activities."; /evidence="ECO:0000269|PubMed:16553580"; MUTAGEN 529; /note="H->A: Impairs SUMO2 processing activity. No effect on SUMO2 deconjugating activity."; /evidence="ECO:0000269|PubMed:16553580"; MUTAGEN 532; /note="V->A: No effect on SUMO2 processing and SUMO2 deconjugating activities."; /evidence="ECO:0000269|PubMed:16553580"; MUTAGEN 533; /note="H->A: Abolishes SUMO2 processing and SUMO2 deconjugating activities."; /evidence="ECO:0000269|PubMed:16553580"; MUTAGEN 534; /note="W->A: Abolishes SUMO2 processing and SUMO2 deconjugating activities."; /evidence="ECO:0000269|PubMed:16553580"; MUTAGEN 550; /note="D->A: Abolishes SUMO2 processing and SUMO2 deconjugating activities."; /evidence="ECO:0000269|PubMed:16553580"; MUTAGEN 597; /note="Q->A: Abolishes SUMO2 processing and SUMO2 deconjugating activities."; /evidence="ECO:0000269|PubMed:16553580"; MUTAGEN 603; /note="C->A,S: Abolishes SUMO2 processing and SUMO2 deconjugating activities."; /evidence="ECO:0000269|PubMed:14563852, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:16712526"; MUTAGEN 603; /note="C->S: Exclusively nuclear. Loss of CCAR2 desumoylation."; /evidence="ECO:0000269|PubMed:14563852, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:16712526, ECO:0000269|PubMed:25406032
uniprot
proteins
protein_family
Peptidase C48 family
uniprot
proteins
pubmed
10652325
uniprot
proteins
pubmed
14563852
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15199155
uniprot
proteins
pubmed
15487983
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16253240
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16553580
uniprot
proteins
pubmed
16712526
uniprot
proteins
pubmed
17099698
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21829689
uniprot
proteins
pubmed
21965678
uniprot
proteins
pubmed
23160374
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24943844
uniprot
proteins
pubmed
25406032
uniprot
proteins
pubmed
29506078
uniprot
proteins
pubmed
34048572
uniprot
proteins
pubmed
37257451
uniprot
proteins
sequence_length
644
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14563852, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:25406032}. Cytoplasm {ECO:0000269|PubMed:14563852, ECO:0000269|PubMed:16253240}. Note=Shuttles between cytoplasm and nucleus. {ECO:0000269|PubMed:14563852}.
uniprot
proteins