Parp3
entrez
235587
canonical
uniprot
Q3ULW8
canonical
ensembl
ENSMUSG00000023249
resolver
ensp
ENSMUSP00000064513
resolver
ensp
ENSMUSP00000108098
resolver
ensp
ENSMUSP00000123054
resolver
ensp
ENSMUSP00000302500
resolver
genesymbol
Parp3
resolver
genesymbol_syn
Adprt3
resolver
uniprot
A0A1L1SRP6
resolver
uniprot
E9PX17
resolver
uniprot
E9Q992
resolver
uniprot
Q3UGL7
resolver
uniprot
Q8BHN6
resolver
uniprot
Q8BXU2
resolver
uniprot
Q8CFB8
resolver
uniprot
Q91YR6
resolver
uniprot_entry
PARP3_MOUSE
resolver
uniprot_sec
A0A1L1SRP6
resolver
uniprot_sec
E9PX17
resolver
uniprot_sec
E9Q992
resolver
uniprot_sec
Q3UGL7
resolver
uniprot_sec
Q8BHN6
resolver
uniprot_sec
Q8BXU2
resolver
uniprot_sec
Q8CFB8
resolver
uniprot_sec
Q91YR6
resolver
amino_acid_sequence
MAPKRKASVQTEGSKKRRQGTEEEDSFRSTAEALRAAPADNRVIRVDPSCPFSRNPGIQVHEDYDCTLNQTNIGNNNNKFYIIQLLEEGSRFFCWNRWGRVGEVGQSKMNHFTCLEDAKKDFKKKFWEKTKNKWEERDRFVAQPNKYTLIEVQGEAESQEAVVKALSPQVYSGPVRTVVKPCSLDPATQNLITNIFSKEMFKNAMTLMNLDVKKMPLGKLTKQQIARGFEALEALEEAMKNPTGDGQSLEELSSCFYTVIPHNFGRSRPPPINSPDVLQAKKDMLLVLADIELAQTLQAAPGEEEEKVEEVPHPLDRDYQLLRCQLQLLDSGESEYKAIQTYLKQTGNSYRCPDLRHVWKVNREGEGDRFQAHSKLGNRRLLWHGTNVAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVTTMHCGGHQVGYMFLGEVALGKEHHITIDDPSLKSPPSGFDSVIARGQTEPDPAQDIELELDGQPVVVPQGPPVQCPSFKSSSFSQSEYLIYKESQCRLRYLLEIHL
uniprot
proteins
ec_number
2.4.2.-
uniprot
proteins
function
FUNCTION: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:21270334, PubMed:24598253). Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (By similarity). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as histone H2B, XRCC5 and XRCC6 (By similarity). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity). Involved in single-strand break repair by catalyzing mono-ADP-ribosylation of histone H2B on 'Glu-2' (H2BE2ADPr) of nucleosomes containing nicked DNA (By similarity). Cooperates with the XRCC5-XRCC6 (Ku80-Ku70) heterodimer to limit end-resection thereby promoting accurate NHEJ (By similarity). Suppresses G-quadruplex (G4) structures in response to DNA damage (By similarity). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (PubMed:21270334). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (By similarity). May link the DNA damage surveillance network to the mitotic fidelity checkpoint (By similarity). Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (PubMed:26000965). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (By similarity). {ECO:0000250|UniProtKB:Q9Y6F1, ECO:0000269|PubMed:21270334, ECO:0000269|PubMed:24598253, ECO:0000269|PubMed:26000965}.
uniprot
proteins
mass_dalton
59949
uniprot
proteins
post_translational_modification
PTM: Auto-ADP-ribosylated. {ECO:0000250|UniProtKB:Q9Y6F1}.
uniprot
proteins
protein_family
ARTD/PARP family
uniprot
proteins
pubmed
12448766
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21270334
uniprot
proteins
pubmed
24598253
uniprot
proteins
pubmed
26000965
uniprot
proteins
pubmed
30213852
uniprot
proteins
sequence_length
533
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y6F1}. Chromosome {ECO:0000250|UniProtKB:Q9Y6F1}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9Y6F1}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9Y6F1}. Note=Almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected. In response to DNA damage, localizes to sites of double-strand break. Also localizes to single-strand breaks. Preferentially localized to the daughter centriole. {ECO:0000250|UniProtKB:Q9Y6F1}.
uniprot
proteins