Ctbs
entrez
74245
canonical
uniprot
Q8R242
canonical
ensembl
ENSMUSG00000028189
resolver
ensp
ENSMUSP00000029840
resolver
ensp
ENSMUSP00000059167
resolver
genesymbol
Ctbs
resolver
uniprot
Q102J0
resolver
uniprot
Q9D7V4
resolver
uniprot_entry
DIAC_MOUSE
resolver
uniprot_sec
Q102J0
resolver
uniprot_sec
Q9D7V4
resolver
amino_acid_sequence
MALCGLPEFTLLLLPLLARLSAGDCPCSEAALCQPIRHRPDFEVFVFDVGQKTWKSYDWSQITTVAAFGKYDPELMCYAHSKGARVVLKGDISLKNIIDPTFRASWIAQKVDLAKAQYMDGINIDIEQEVNCSSPEYEALTALVKETTESFQREIEGSQVTFDVAWSPKRIDKRCYNYTGIADACDFLFVMSYDEQSQIWSECIAAANAPYNQTLTGYIDYIKMGISPKKLVMGVPWYGYDYICLNLSKDDICTITKVPFRGAPCSDAAGHQVPYKVIMKQVNGSVSGSQWNKDQQAPYYNYKDPAGRFHQVWYDNPQSISLKAAYVKNYGLRGIGMWNANCLDYSDDALAREQTQEMWGALKPRL
uniprot
proteins
ec_number
3.2.1.-
uniprot
proteins
function
FUNCTION: Reducing-end exoglycosidase involved in glycan degradation (PubMed:18440730, PubMed:22465033, PubMed:32799730). Hydrolyzes N,N'-diacetylchitobiose (GlnNAc2) and higher chitin-oligosaccharides (GlcNAc(n)) to monomeric GlcNAc acting on reducing-end residues (PubMed:18440730, PubMed:32799730). During N-linked glycoprotein degradation, it cleaves single GlcNAc molecules uniquely from the reducing end of N,N'-diacetylchitobiose units linking oligosaccharides to proteins, and therefore it functions after cleavage of the Asn-GlcNAc bond and asparagine removal by glycosylasparaginase (By similarity). {ECO:0000250|UniProtKB:Q01460, ECO:0000269|PubMed:18440730, ECO:0000269|PubMed:22465033, ECO:0000269|PubMed:32799730}.
uniprot
proteins
mass_dalton
41295
uniprot
proteins
pathway_participation
PATHWAY: Glycan metabolism; N-glycan degradation. {ECO:0000269|PubMed:22465033}.; PATHWAY: Glycan degradation; chitin degradation. {ECO:0000269|PubMed:32799730}.
uniprot
proteins
protein_family
Glycosyl hydrolase 18 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18440730
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22465033
uniprot
proteins
pubmed
32799730
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q01460}.
uniprot
proteins