Il1rl1
entrez
25556
canonical
uniprot
Q62611
canonical
ensembl
ENSRNOG00000014835
resolver
ensembl
ENSRNOG00055019782
resolver
ensembl
ENSRNOG00060026733
resolver
ensp
ENSRNOP00000020108
resolver
ensp
ENSRNOP00000103721
resolver
enst
ENSRNOT00000020108
resolver
genesymbol
Il1rl1
resolver
genesymbol_syn
Fit1
resolver
uniprot
F1LR63
resolver
uniprot
Q62612
resolver
uniprot_entry
F1LR63_RAT
resolver
uniprot_entry
ILRL1_RAT
resolver
uniprot_sec
Q62612
resolver
amino_acid_sequence
MIGKWRMGLWALAILTVPMYFIVTEGRKTSWGLENEALIVRCPQRGGAINPVEWYYSNTNERIPTQKRNRIFVSRDRLKFLPAKVEDSGIYTCVIRSPESIKTGSLNVTIYKRPPNCKIPDYMMYSTVDGSDKNSKITCPTIALYNWTAPVQWFKNCKALQGPRFRAHMSYLFIDKVSHVDEGDYTCRFTHTENGTNYIVTATRSFTVEEKGFSTFPVITNPPHNYTVEVEIGKTANIACSACFGTASQFVAVLWQINKTRIGSFGKARIQEEKGPNKSSSNGMICLTSLLRITGVTDKDFSLKYDCVAMNHHGVIRHPVRLRRKQPIDHQSTYYIVAGCSLLLMFINVLVIVLKVFWIEVALFWRDIMAPYKTQNDGKLYDAYIIYPRVFRGSAAGTGSVEYFVHYTLPDVLENKCGYKLCIYGRDLLPGQDAATVVESSIQNSRRQVFVLAPHMMHSKEFAYEQEIALHSALIQNNSKVILIEMEPMGEASRLQLGDLQDSLQHLVKMQGTIKWREDHVADKQSLSSKFWKHVRYQMPVPKRPPKMASVAAPLSGKVCLDLKHF
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (By similarity). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. {ECO:0000250|UniProtKB:P14719, ECO:0000250|UniProtKB:Q01638}.; FUNCTION: [Isoform B]: Inhibits IL-33 signaling. {ECO:0000250|UniProtKB:P14719}.
uniprot
proteins
mass_dalton
64406
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3B at Ser-441; leading to proteasomal degradation. {ECO:0000250|UniProtKB:P14719}.; PTM: Ubiquitinated at Lys-325 in a FBXL19-mediated manner; leading to proteasomal degradation. Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response. {ECO:0000250|UniProtKB:P14719, ECO:0000250|UniProtKB:Q01638}.
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
8131748
uniprot
proteins
sequence_length
566
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform B]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 332..354; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins