NGFR
entrez
4804
canonical
uniprot
P08138
canonical
ensembl
ENSG00000064300
resolver
ensp
ENSP00000172229
resolver
genesymbol
NGFR
resolver
genesymbol_syn
TNFRSF16
resolver
hgnc
HGNC:7809
resolver
uniprot
B2R961
resolver
uniprot
B4E096
resolver
uniprot_entry
TNR16_HUMAN
resolver
uniprot_sec
B2R961
resolver
uniprot_sec
B4E096
resolver
amino_acid_sequence
MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSESTATSPV
uniprot
proteins
function
FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). Together with BFAR negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed:22566094). {ECO:0000250, ECO:0000250|UniProtKB:Q9Z0W1, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:3022937}.
uniprot
proteins
mass_dalton
45183
uniprot
proteins
mutagenesis
MUTAGEN 343; /note="K->A: Decreased interaction with ARHGDIA."; /evidence="ECO:0000269|PubMed:26646181"; MUTAGEN 412; /note="D->A: Decreased interaction with ARHGDIA."; /evidence="ECO:0000269|PubMed:26646181"; MUTAGEN 420; /note="E->A: Decreased interaction with ARHGDIA."; /evidence="ECO:0000269|PubMed:26646181
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated.; PTM: O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.; PTM: Phosphorylated on serine residues.
uniprot
proteins
pubmed
10514511
uniprot
proteins
pubmed
10544233
uniprot
proteins
pubmed
11244088
uniprot
proteins
pubmed
12963025
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14966521
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19052207
uniprot
proteins
pubmed
22155786
uniprot
proteins
pubmed
22566094
uniprot
proteins
pubmed
23785138
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24908487
uniprot
proteins
pubmed
26646181
uniprot
proteins
pubmed
2850481
uniprot
proteins
pubmed
3022937
uniprot
proteins
pubmed
8627329
uniprot
proteins
pubmed
9915784
uniprot
proteins
sequence_length
427
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:3022937}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:22566094}. Perikaryon {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z0W1}.
uniprot
proteins
transmembrane_region
TRANSMEM 251..272; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins