Spaar
entrez
71406
canonical
uniprot
A0A1B0GSZ0
canonical
ensembl
ENSMUSG00000028475
resolver
ensp
ENSMUSP00000148128
resolver
enst
ENSMUST00000131248
resolver
genesymbol
Spaar
resolver
genesymbol_syn
5430416O09Rik
resolver
genesymbol_syn
Spar
resolver
uniprot
Q9D3L1
resolver
uniprot_entry
Q9D3L1_MOUSE
resolver
uniprot_entry
SPAR_MOUSE
resolver
amino_acid_sequence
METAVIGMVAVLFVITMAITCILCYFSYDSHTQDPERSSRRSFTVATFHQEASLFTGPALQSRPLPRPQNFWTVV
uniprot
proteins
function
FUNCTION: Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (By similarity). Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (By similarity). Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (PubMed:28024296). {ECO:0000250|UniProtKB:A0A1B0GVQ0, ECO:0000269|PubMed:28024296}.
uniprot
proteins
mass_dalton
8470
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
28024296
uniprot
proteins
sequence_length
75
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:A0A1B0GVQ0}; Single-pass membrane protein {ECO:0000250|UniProtKB:A0A1B0GVQ0}. Lysosome membrane {ECO:0000250|UniProtKB:A0A1B0GVQ0}; Single-pass membrane protein {ECO:0000250|UniProtKB:A0A1B0GVQ0}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins