RPL3
entrez
6122
canonical
uniprot
P39023
canonical
ensembl
ENSG00000100316
resolver
ensp
ENSP00000346001
resolver
ensp
ENSP00000596294
resolver
enst
ENST00000216146
resolver
genesymbol
RPL3
resolver
hgnc
HGNC:10332
resolver
uniprot
B2RDV9
resolver
uniprot
B3KS36
resolver
uniprot
Q15548
resolver
uniprot
Q5I0G0
resolver
uniprot
Q96QL0
resolver
uniprot_entry
B3KS36_HUMAN
resolver
uniprot_entry
Q96QL0_HUMAN
resolver
uniprot_entry
RL3_HUMAN
resolver
uniprot_sec
B2RDV9
resolver
uniprot_sec
Q15548
resolver
uniprot_sec
Q5I0G0
resolver
amino_acid_sequence
MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVDRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKNWHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHLMEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLPRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKNNASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRALEKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA
uniprot
proteins
function
FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547, PubMed:35674491). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.
uniprot
proteins
mass_dalton
46109
uniprot
proteins
mutagenesis
MUTAGEN 246..249; /note="RGLR->AGLA: No effect on methylation by METTL18."; /evidence="ECO:0000269|PubMed:33693809
uniprot
proteins
post_translational_modification
PTM: Constitutively monomethylated at His-245 by METTL18 (PubMed:23349634, PubMed:33693809, PubMed:35674491). Methylation at His-245 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins (PubMed:35674491). It is not required for incorporation of RPL3 into ribosomes (PubMed:33693809). {ECO:0000269|PubMed:23349634, ECO:0000269|PubMed:33693809, ECO:0000269|PubMed:35674491}.
uniprot
proteins
protein_family
Universal ribosomal protein uL3 family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12962325
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16963496
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22431104
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23349634
uniprot
proteins
pubmed
23636399
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24524803
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26100019
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
32669547
uniprot
proteins
pubmed
33693809
uniprot
proteins
pubmed
35674491
uniprot
proteins
pubmed
40174224
uniprot
proteins
pubmed
7576925
uniprot
proteins
pubmed
9582194
uniprot
proteins
sequence_length
403
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16963496}. Cytoplasm {ECO:0000269|PubMed:16963496, ECO:0000269|PubMed:23636399}.
uniprot
proteins