PWWP2B
entrez
170394
canonical
uniprot
Q6NUJ5
canonical
ensembl
ENSG00000171813
resolver
ensp
ENSP00000306324
resolver
ensp
ENSP00000486501
resolver
genesymbol
PWWP2B
resolver
genesymbol_syn
PWWP2
resolver
hgnc
HGNC:25150
resolver
uniprot
A6NM90
resolver
uniprot
B5MDQ1
resolver
uniprot
H9KV61
resolver
uniprot
Q5SZI0
resolver
uniprot
Q6ZQX5
resolver
uniprot
Q96F43
resolver
uniprot_entry
PWP2B_HUMAN
resolver
uniprot_sec
A6NM90
resolver
uniprot_sec
B5MDQ1
resolver
uniprot_sec
H9KV61
resolver
uniprot_sec
Q5SZI0
resolver
uniprot_sec
Q6ZQX5
resolver
uniprot_sec
Q96F43
resolver
amino_acid_sequence
MEPRAGCRLPVRVEQVVNGALVVTVSCGERSFAGILLDCTKKSGLFGLPPLAPLPQVDESPVNDSHGRAPEEGDAEVMQLGSSSPPPARGVQPPETTRPEPPPPLVPPLPAGSLPPYPPYFEGAPFPHPLWLRDTYKLWVPQPPPRTIKRTRRRLSRNRDPGRLILSTIRLRPRQVLCEKCKSTLSPPEASPGPPAAPRARRRLGSGPDRELRKPEEPENGEPTAAATARRSKRERREEDRAPAEQVPRSPVIKISYSTPQGKGEVVKIPSRVHGSLEPFRPQQAPQDDGSQDPEVLDRESRDRPSCAPSASIPKLKLTRPVPAGADLPPPKIRLKPHRLGDSEHEPVYRAELVGELNGYLRDSSPAPCADGPAGGLADLSSGSSGEDDDFKSCPQGPQGREGLAFLVSCPEGRADCASESACSSDSLDEARSSGSEGTPADTGDLSPGHGASAPSVSREARQTVPPLTVRLHTQSVSECITEDGRTVAVGDIVWGKIHGFPWWPARVLDISLGQKEDGEPSWREAKVSWFGSPTTSFLSISKLSPFSEFFKLRFNRKKKGMYRKAITEAANAARHVAPEIRELLTQFET
uniprot
proteins
function
FUNCTION: Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}.
uniprot
proteins
mass_dalton
63967
uniprot
proteins
post_translational_modification
PTM: Deubiquitinated by BRCC3; leading to its stabilization. {ECO:0000250|UniProtKB:Q69Z61}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30228260
uniprot
proteins
sequence_length
590
uniprot
proteins