Htr1a
entrez
24473
canonical
uniprot
P19327
canonical
ensembl
ENSRNOG00000010254
resolver
ensp
ENSRNOP00000013618
resolver
ensp
ENSRNOP00000109112
resolver
enst
ENSRNOT00000013618
resolver
enst
ENSRNOT00000145858
resolver
genesymbol
Htr1a
resolver
genesymbol_syn
5ht1a
resolver
uniprot
G3V7B9
resolver
uniprot_entry
5HT1A_RAT
resolver
uniprot_entry
G3V7B9_RAT
resolver
activity_regulation
ACTIVITY REGULATION: G protein-coupled receptor activity is regulated by lipids: phosphatidylinositol 4-phosphate increases HTR1A-mediated activity. {ECO:0000250|UniProtKB:P08908}.
uniprot
proteins
amino_acid_sequence
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:2140514, PubMed:2156831). Also functions as a receptor for various drugs and psychoactive substances (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (By similarity). Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes (By similarity). {ECO:0000250|UniProtKB:P08908, ECO:0000269|PubMed:2140514, ECO:0000269|PubMed:2156831}.
uniprot
proteins
mass_dalton
46429
uniprot
proteins
protein_family
5-hydroxytryptamine receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
HTR1A sub-subfamily
uniprot
proteins
pubmed
18685031
uniprot
proteins
pubmed
2140514
uniprot
proteins
pubmed
2156831
uniprot
proteins
pubmed
2167416
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2156831}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08908}. Cell projection, dendrite {ECO:0000269|PubMed:18685031}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P08908"; TRANSMEM 74..98; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P08908"; TRANSMEM 108..132; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P08908"; TRANSMEM 153..174; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P08908"; TRANSMEM 194..216; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P08908"; TRANSMEM 347..370; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P08908"; TRANSMEM 379..403; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P08908
uniprot
proteins