Castor2
entrez
80909
canonical
uniprot
Q8CAB8
canonical
ensembl
ENSMUSG00000015944
resolver
ensp
ENSMUSP00000016088
resolver
enst
ENSMUST00000016088
resolver
genesymbol
Castor2
resolver
genesymbol_syn
Gats
resolver
genesymbol_syn
Gatsl2
resolver
uniprot
Q8C7A9
resolver
uniprot
Q9ER44
resolver
uniprot_entry
CAST2_MOUSE
resolver
uniprot_sec
Q8C7A9
resolver
uniprot_sec
Q9ER44
resolver
amino_acid_sequence
MELHILEHRLQVASVAKESIPLFTYGLIKLAFLSSKTRCKFFSLTETPEDYTIIVDEEGFLELPSSEHLSVADATWLALNVVSGGGSFSSSQPIGVTKIAKSVIAPLADQNISVFMLSTYQTDFILVRERDLPFVTHTLSSEFTILRVVNGETVAAENLSFTNGFVKPKMVQRPVIHPLSSPSNRFCVTSLDPDTLPAVATLLMDVMFYSNGVKDPMAASDDCGHIRFFSFSLIEGYISLVMDVQTQQRFPSHLLFTSASGELWKMVRIGGQPLGFDECGIVAQISEPLAAADIPAYYISTFKFDHALVPEENISGVIHALKVSQAGKH
uniprot
proteins
function
FUNCTION: Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. {ECO:0000250|UniProtKB:A6NHX0}.
uniprot
proteins
mass_dalton
36112
uniprot
proteins
protein_family
GATS family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:A6NHX0}.
uniprot
proteins