Abcg8
entrez
155192
canonical
uniprot
P58428
canonical
ensembl
ENSRNOG00000005420
resolver
ensembl
ENSRNOG00055021496
resolver
ensembl
ENSRNOG00060013739
resolver
ensp
ENSRNOP00000007638
resolver
genesymbol
Abcg8
resolver
uniprot
Q8CIQ5
resolver
uniprot
Q923R7
resolver
uniprot_entry
ABCG8_RAT
resolver
uniprot_sec
Q8CIQ5
resolver
uniprot_sec
Q923R7
resolver
amino_acid_sequence
MAEKTKEETQLWNGTVLQDASSLQDSVFSSESDNSLYFTYSGQSNTLEVRDLTYQGGTCLRSWGQEDPHMSLGLSESVDMASQVPWFEQLAQFKLPWRSRGSQDSWDLGIRNLSFKVRSGQMLAIIGSAGCGRATLLDVITGRDHGGKMKSGQIWINGQPSTPQLIQKCVAHVRQQDQLLPNLTVRETLTFIAQMRLPKTFSQAQRDKRVEDVIAELRLRQCANTRVGNTYVRGVSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVRTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGVAQHMVQYFTSIGYPCPRYSNPADFYVDLTSIDRRSKEQEVATMEKARLLAALFLEKVQGFDDFLWKAEAKSLDTGTYAVSQTLTQDTNCGTAAELPGMIQQFTTLIRRQISNDFRDLPTLFIHGAEACLMSLIIGFLYYGHADKPLSFMDMAALLFMIGALIPFNVILDVVSKCHSERSLLYYELEDGLYTAGPYFFAKVLGELPEHCAYVIIYGMPIYWLTNLRPGPELFLLHFMLLWLVVFCCRTMALAASAMLPTFHMSSFCCNALYNSFYLTAGFMINLNNLWIVPAWISKMSFLRWCFSGLMQIQFNGHIYTTQIGNLTFSVPGDAMVTAMDLNSHPLYAIYLIVIGISCGFLSLYYLSLKFIKQKSIQDW
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
function
FUNCTION: ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG5 has ATPase activity. {ECO:0000250|UniProtKB:Q9H221}.
uniprot
proteins
mass_dalton
78236
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. N-glycosylation is important for efficient export out of the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q9DBM0}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCG family
uniprot
proteins
protein_family
Eye pigment precursor importer (TC 3.A.1.204) subfamily
uniprot
proteins
pubmed
11452359
uniprot
proteins
pubmed
12783625
uniprot
proteins
sequence_length
694
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H221}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H221}. Apical cell membrane {ECO:0000250|UniProtKB:Q9H221}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H221}.
uniprot
proteins
transmembrane_region
TRANSMEM 438..458; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9H221"; TRANSMEM 469..489; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9H221"; TRANSMEM 519..539; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9H221"; TRANSMEM 549..569; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9H221"; TRANSMEM 577..597; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9H221"; TRANSMEM 661..681; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9H221
uniprot
proteins