HLA-G
entrez
3135
canonical
uniprot
P17693
canonical
ensembl
ENSG00000204632
resolver
ensembl
ENSG00000206506
resolver
ensembl
ENSG00000230413
resolver
ensembl
ENSG00000233095
resolver
ensembl
ENSG00000235346
resolver
ensembl
ENSG00000235680
resolver
ensembl
ENSG00000237216
resolver
ensembl
ENSG00000276051
resolver
ensp
ENSP00000353472
resolver
ensp
ENSP00000366014
resolver
ensp
ENSP00000366024
resolver
ensp
ENSP00000373118
resolver
ensp
ENSP00000383506
resolver
ensp
ENSP00000383521
resolver
ensp
ENSP00000387624
resolver
ensp
ENSP00000390678
resolver
ensp
ENSP00000392075
resolver
ensp
ENSP00000392347
resolver
ensp
ENSP00000396594
resolver
ensp
ENSP00000397331
resolver
ensp
ENSP00000397733
resolver
ensp
ENSP00000408461
resolver
ensp
ENSP00000409132
resolver
ensp
ENSP00000415905
resolver
ensp
ENSP00000432220
resolver
ensp
ENSP00000432239
resolver
ensp
ENSP00000433426
resolver
ensp
ENSP00000434622
resolver
ensp
ENSP00000436375
resolver
ensp
ENSP00000437036
resolver
ensp
ENSP00000479043
resolver
ensp
ENSP00000479303
resolver
ensp
ENSP00000482111
resolver
ensp
ENSP00000482272
resolver
enst
ENST00000376818
resolver
enst
ENST00000376828
resolver
enst
ENST00000383623
resolver
enst
ENST00000400665
resolver
enst
ENST00000400682
resolver
enst
ENST00000412263
resolver
enst
ENST00000420559
resolver
enst
ENST00000422371
resolver
enst
ENST00000426863
resolver
enst
ENST00000430253
resolver
enst
ENST00000434881
resolver
enst
ENST00000434907
resolver
enst
ENST00000450984
resolver
enst
ENST00000452577
resolver
enst
ENST00000452715
resolver
enst
ENST00000466488
resolver
enst
ENST00000467814
resolver
enst
ENST00000469347
resolver
enst
ENST00000469472
resolver
enst
ENST00000478519
resolver
enst
ENST00000486553
resolver
enst
ENST00000612360
resolver
enst
ENST00000615098
resolver
enst
ENST00000618039
resolver
enst
ENST00000618812
resolver
genesymbol
HLA-G
resolver
genesymbol
HLA-G2.2
resolver
genesymbol_syn
HLA-6.0
resolver
genesymbol_syn
HLA-G
resolver
genesymbol_syn
HLAG
resolver
hgnc
HGNC:4964
resolver
uniprot
A0A024RCI4
resolver
uniprot
A0A0G2JNX1
resolver
uniprot
F6UBT4
resolver
uniprot
Q31611
resolver
uniprot
Q5RJ85
resolver
uniprot
Q6DU14
resolver
uniprot
Q8MH48
resolver
uniprot_entry
A0A0G2JNX1_HUMAN
resolver
uniprot_entry
F6UBT4_HUMAN
resolver
uniprot_entry
HLAG_HUMAN
resolver
uniprot_entry
Q31611_HUMAN
resolver
uniprot_entry
Q5RJ85_HUMAN
resolver
uniprot_entry
Q6DU14_HUMAN
resolver
uniprot_entry
Q8MH48_HUMAN
resolver
uniprot_sec
A0A024RCI4
resolver
amino_acid_sequence
MVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDTQFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEASSHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAANVAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPAEIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLMLRWKQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD
uniprot
proteins
function
FUNCTION: [Isoform 1]: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:19304799, PubMed:23184984, PubMed:29262349). In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247). Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:16366734, PubMed:19304799, PubMed:20448110, PubMed:23184984, PubMed:27859042, PubMed:29262349). Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:16366734, PubMed:19304799, PubMed:23184984, PubMed:29262349). Through interaction with KIR2DL4 receptor on decidual macrophages induces pro-inflammatory cytokine production mainly associated with tissue remodeling (PubMed:19304799). Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:11290782, PubMed:24453251). Reprograms B cells toward an immune suppressive phenotype via LILRB1 (PubMed:24453251). May induce immune activation/suppression via intercellular membrane transfer (trogocytosis), likely enabling interaction with KIR2DL4, which resides mostly in endosomes (PubMed:20179272, PubMed:26460007). Through interaction with the inhibitory receptor CD160 on endothelial cells may control angiogenesis in immune privileged sites (PubMed:16809620). {ECO:0000269|PubMed:10190900, ECO:0000269|PubMed:11290782, ECO:0000269|PubMed:16366734, ECO:0000269|PubMed:16809620, ECO:0000269|PubMed:19304799, ECO:0000269|PubMed:20179272, ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:23184984, ECO:0000269|PubMed:24453251, ECO:0000269|PubMed:26460007, ECO:0000269|PubMed:27859042, ECO:0000269|PubMed:29262349, ECO:0000269|PubMed:7584149, ECO:0000269|PubMed:8805247}.; FUNCTION: [Isoform 2]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782). {ECO:0000269|PubMed:11290782, ECO:0000305}.; FUNCTION: [Isoform 3]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782). {ECO:0000269|PubMed:11290782, ECO:0000305}.; FUNCTION: [Isoform 4]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782). {ECO:0000269|PubMed:11290782, ECO:0000305}.; FUNCTION: [Isoform 5]: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:19304799, PubMed:23184984, PubMed:29262349). In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247). Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:16366734, PubMed:19304799, PubMed:20448110, PubMed:23184984, PubMed:29262349). Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:16366734, PubMed:19304799, PubMed:23184984, PubMed:29262349). Through interaction with KIR2DL4 receptor on decidual macrophages induces pro-inflammatory cytokine production mainly associated with tissue remodeling (PubMed:19304799). Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110). Reprograms B cells toward an immune suppressive phenotype via LILRB1 (PubMed:24453251). {ECO:0000269|PubMed:16366734, ECO:0000269|PubMed:19304799, ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:23184984, ECO:0000269|PubMed:24453251, ECO:0000269|PubMed:29262349, ECO:0000269|PubMed:7584149, ECO:0000269|PubMed:8805247}.; FUNCTION: [Isoform 6]: Likely does not bind B2M and presents peptides. {ECO:0000305}.; FUNCTION: [Isoform 7]: Likely does not bind B2M and presents peptides. {ECO:0000305}.
uniprot
proteins
mass_dalton
38224
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="C->S: Abolishes homodimerization and homotrimerization. Decreases functional interaction with LILRB1. Does not affect homodimerization of isoform 2 and its binding to LILRB2."; /evidence="ECO:0000269|PubMed:12454284, ECO:0000269|PubMed:12874224, ECO:0000269|PubMed:28348268"; MUTAGEN 138; /note="E->H: Enables TAPBP-independent transport to the cell surface."; /evidence="ECO:0000269|PubMed:12582157"; MUTAGEN 138; /note="E->Q: Decreases TAPBP-dependent transport to the cell surface."; /evidence="ECO:0000269|PubMed:12582157"; MUTAGEN 171; /note="C->S: Abolishes homodimerization. Decreases functional interaction with LILRB1."; /evidence="ECO:0000269|PubMed:12874224"; MUTAGEN 334..335; /note="KK->AA: Abolishes binding to COPB1 and Golgi-to-ER retrograde transport."; /evidence="ECO:0000269|PubMed:11520457
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:11290782}.; PTM: [Soluble HLA class I histocompatibility antigen, alpha chain G]: Produced by proteolytic cleavage at the cell surface (shedding) by matrix metalloproteinase MMP2. {ECO:0000269|PubMed:23737137}.
uniprot
proteins
protein_family
MHC class I family
uniprot
proteins
pubmed
10190900
uniprot
proteins
pubmed
10727083
uniprot
proteins
pubmed
11137219
uniprot
proteins
pubmed
11290782
uniprot
proteins
pubmed
11520457
uniprot
proteins
pubmed
12454284
uniprot
proteins
pubmed
12582157
uniprot
proteins
pubmed
12853576
uniprot
proteins
pubmed
12874224
uniprot
proteins
pubmed
1570318
uniprot
proteins
pubmed
15718280
uniprot
proteins
pubmed
16210391
uniprot
proteins
pubmed
16366734
uniprot
proteins
pubmed
16455647
uniprot
proteins
pubmed
16809620
uniprot
proteins
pubmed
17056715
uniprot
proteins
pubmed
19304799
uniprot
proteins
pubmed
20122941
uniprot
proteins
pubmed
20179272
uniprot
proteins
pubmed
20448110
uniprot
proteins
pubmed
23184984
uniprot
proteins
pubmed
2336406
uniprot
proteins
pubmed
23737137
uniprot
proteins
pubmed
24453251
uniprot
proteins
pubmed
26460007
uniprot
proteins
pubmed
27859042
uniprot
proteins
pubmed
28348268
uniprot
proteins
pubmed
29262349
uniprot
proteins
pubmed
3480534
uniprot
proteins
pubmed
37264229
uniprot
proteins
pubmed
7558941
uniprot
proteins
pubmed
7584149
uniprot
proteins
pubmed
7589701
uniprot
proteins
pubmed
7989753
uniprot
proteins
pubmed
8183892
uniprot
proteins
pubmed
8805247
uniprot
proteins
pubmed
9640257
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:7584149}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11520457}. Early endosome membrane {ECO:0000269|PubMed:16366734}.; SUBCELLULAR LOCATION: [Soluble HLA class I histocompatibility antigen, alpha chain G]: Secreted {ECO:0000269|PubMed:23737137}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11290782}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:11290782}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:11290782}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted {ECO:0000269|PubMed:11137219, ECO:0000269|PubMed:7558941, ECO:0000269|PubMed:7584149, ECO:0000269|PubMed:7989753}. Early endosome {ECO:0000269|PubMed:16366734}.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted {ECO:0000269|PubMed:7989753}.; SUBCELLULAR LOCATION: [Isoform 7]: Secreted {ECO:0000269|PubMed:11137219}.; SUBCELLULAR LOCATION: Cell projection, filopodium membrane {ECO:0000269|PubMed:26460007}. Note=HLA-G trogocytosis from extravillous trophoblast's filopodia occurs in the majority of decidual NK cells. {ECO:0000269|PubMed:26460007}.
uniprot
proteins
transmembrane_region
TRANSMEM 309..332; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins