SEMA7A
entrez
8482
canonical
uniprot
O75326
canonical
ensembl
ENSG00000138623
resolver
ensembl
ENSG00000288455
resolver
ensp
ENSP00000261918
resolver
ensp
ENSP00000438966
resolver
ensp
ENSP00000441493
resolver
ensp
ENSP00000500636
resolver
enst
ENST00000542748
resolver
enst
ENST00000672707
resolver
genesymbol
SEMA7A
resolver
genesymbol_syn
CD108
resolver
genesymbol_syn
SEMAL
resolver
hgnc
HGNC:10741
resolver
uniprot
B3KMH6
resolver
uniprot
B4DDP7
resolver
uniprot
F5GYX3
resolver
uniprot
F5H1S0
resolver
uniprot
Q1XE81
resolver
uniprot
Q1XE82
resolver
uniprot
Q1XE83
resolver
uniprot
Q1XE84
resolver
uniprot
Q3MIY5
resolver
uniprot_entry
B3KMH6_HUMAN
resolver
uniprot_entry
F5GYX3_HUMAN
resolver
uniprot_entry
SEM7A_HUMAN
resolver
uniprot_sec
B4DDP7
resolver
uniprot_sec
F5H1S0
resolver
uniprot_sec
Q1XE81
resolver
uniprot_sec
Q1XE82
resolver
uniprot_sec
Q1XE83
resolver
uniprot_sec
Q1XE84
resolver
uniprot_sec
Q3MIY5
resolver
amino_acid_sequence
MTPPPPGRAAPSAPRARVPGPPARLGLPLRLRLLLLLWAAAASAQGHLRSGPRIFAVWKGHVGQDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRTVNIGSTKGSCLDKRDCENYITLLERRSEGLLACGTNARHPSCWNLVNGTVVPLGEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDKVFRTSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRCISIYSSERSVLQSINPAEPHKECPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALAASLWLGVLPTLTLGLLVH
uniprot
proteins
disease_involvement
DISEASE: Cholestasis, progressive familial intrahepatic, 11 (PFIC11) [MIM:619874]: An autosomal recessive form of progressive cholestasis, a disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease. {ECO:0000269|PubMed:34585848}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. {ECO:0000269|PubMed:12879062, ECO:0000269|PubMed:17377534, ECO:0000269|PubMed:17671519}.
uniprot
proteins
mass_dalton
74824
uniprot
proteins
mutagenesis
MUTAGEN 267; /note="R->K: Abolishes ITGB1-dependent enhancement of axon growth; when associated with E-269."; /evidence="ECO:0000269|PubMed:12879062"; MUTAGEN 269; /note="D->E: Abolishes ITGB1-dependent enhancement of axon growth; when associated with K-267."; /evidence="ECO:0000269|PubMed:12879062
uniprot
proteins
protein_family
Semaphorin family
uniprot
proteins
pubmed
10201933
uniprot
proteins
pubmed
10416131
uniprot
proteins
pubmed
12879062
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17207242
uniprot
proteins
pubmed
17377534
uniprot
proteins
pubmed
17671519
uniprot
proteins
pubmed
20727575
uniprot
proteins
pubmed
20854351
uniprot
proteins
pubmed
34585848
uniprot
proteins
pubmed
9712866
uniprot
proteins
pubmed
9721204
uniprot
proteins
sequence_length
666
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}; Extracellular side {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}. Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
uniprot
proteins