Marchf11
entrez
499558
canonical
uniprot
A6P320
canonical
ensembl
ENSRNOG00000024461
resolver
ensp
ENSRNOP00000083775
resolver
enst
ENSRNOT00000102916
resolver
genesymbol
Marchf11
resolver
genesymbol_syn
March11
resolver
uniprot
A0A8I6GB48
resolver
uniprot_entry
A0A8I6GB48_RAT
resolver
uniprot_entry
MARHB_RAT
resolver
amino_acid_sequence
MSDEGSKRGSRADSLEAEPPLPPPPPPPPPGESSLVPTSPRYRPPLPAPLERIVGSGEPPVELAPRRKGEPLPPLPPSRLPGDQEVSAAGDSCEGPRRLPEVKLPEAAAGKGSPAEPEAGACREGERRGTGDQPETRSVYSSRSSSSGGSGDQRSGHQHQHHQPICKICFQGAEQGELLNPCRCDGSVRYTHQLCLLKWISERGSWTCELCCYRYHVTAIKMKQPCQWQSISITLVEKVQMIAVILGSLFLIASVTWLLWSAFSPYAVWQRKDILFQICYGMYGFMDLVCIGLIVHEGAAVYRVFKRWRAVNLHWDVLNYDKATDIEESSRGESSTSRTLWLPLSALRNRNLVHPTQLTSPRFQCGYVLLHLFNRMRAHEDVSEDNGSGEVVMRVTSV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids. {ECO:0000269|PubMed:17604280}.
uniprot
proteins
mass_dalton
44085
uniprot
proteins
mutagenesis
MUTAGEN 169; /note="C->S: Abolishes ubiquitin ligase activity; when associated with S-182 and S-184."; /evidence="ECO:0000269|PubMed:17604280"; MUTAGEN 182; /note="C->S: Abolishes ubiquitin ligase activity; when associated with S-169 and C-184."; /evidence="ECO:0000269|PubMed:17604280"; MUTAGEN 184; /note="C->S: Abolishes ubiquitin ligase activity; when associated with S-169 and C-182."; /evidence="ECO:0000269|PubMed:17604280"; MUTAGEN 367; /note="Y->A: Abolishes interaction with AP1M1."; /evidence="ECO:0000269|PubMed:17604280"; MUTAGEN 398; /note="Missing: LIN7A."; /evidence="ECO:0000269|PubMed:17604280
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
17604280
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17604280}; Multi-pass membrane protein {ECO:0000269|PubMed:17604280}.
uniprot
proteins
transmembrane_region
TRANSMEM 241..261; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 274..294; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins