ARL16
entrez
339231
canonical
uniprot
Q0P5N6
canonical
ensembl
ENSG00000214087
resolver
ensp
ENSP00000459201
resolver
ensp
ENSP00000461674
resolver
ensp
ENSP00000483183
resolver
enst
ENST00000570561
resolver
enst
ENST00000576135
resolver
enst
ENST00000622299
resolver
genesymbol
ARL16
resolver
hgnc
HGNC:27902
resolver
uniprot
B4E3H0
resolver
uniprot
I3L4Z7
resolver
uniprot_entry
ARL16_HUMAN
resolver
uniprot_entry
I3L4Z7_HUMAN
resolver
uniprot_sec
B4E3H0
resolver
amino_acid_sequence
MCLLLGATGVGKTLLVKRLQEVSSRDGKGDLGEPPPTRPTVGTNLTDIVAQRKITIRELGGCMGPIWSSYYGNCRSLLFVMDASDPTQLSASCVQLLGLLSAEQLAEASVLILFNKIDLPCYMSTEEMKSLIRLPDIIACAKQNITTAEISAREGTGLAGVLAWLQATHRAND
uniprot
proteins
function
FUNCTION: Required for the trafficking of ciliary proteins IFT140 and INPP5E from the Golgi to the cilia, thus playing a role in ciliogenesis (By similarity). Suppresses the RNA sensing activity of RIGI in a GTP-dependent manner (PubMed:21233210). {ECO:0000250|UniProtKB:B1ATY8, ECO:0000269|PubMed:21233210}.
uniprot
proteins
mass_dalton
18551
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="T->N: Loss of the inhibition of RIGI-mediated antiviral response activity. Loss of GTP binding activity. Loss of interaction with RIGI."; /evidence="ECO:0000269|PubMed:21233210
uniprot
proteins
protein_family
Arf family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
21233210
uniprot
proteins
pubmed
35196065
uniprot
proteins
sequence_length
173
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21233210, ECO:0000269|PubMed:35196065}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:35196065}. Mitochondrion {ECO:0000269|PubMed:35196065}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:35196065}. Photoreceptor inner segment {ECO:0000269|PubMed:35196065}. Note=In retinal pigment epithelial cells, localizes along the cilium axoneme in a punctate manner and also in the cytoplasm and mitochondrion (PubMed:35196065). In photoreceptor cells, localizes to the basal body of the connecting cilium and to the inner segment (PubMed:35196065). {ECO:0000269|PubMed:35196065}.
uniprot
proteins