Ghsr
entrez
84022
canonical
uniprot
O08725
canonical
ensembl
ENSRNOG00000024119
resolver
ensembl
ENSRNOG00065023711
resolver
ensp
ENSRNOP00000038418
resolver
ensp
ENSRNOP00065033123
resolver
enst
ENSRNOT00000034960
resolver
enst
ENSRNOT00065040632
resolver
genesymbol
Ghsr
resolver
uniprot_entry
GHSR_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by octanoylated ghrelin; octanoylation is essential for full activation of the receptor (By similarity). Stimulated by anamorelin, which binds to the same binding sites as ghrelin (By similarity). {ECO:0000250|UniProtKB:Q92847}.
uniprot
proteins
amino_acid_sequence
MWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
uniprot
proteins
function
FUNCTION: G protein-coupled receptor specific to ghrelin, an appetite-regulating peptide hormone commonly found in stomach (PubMed:25605885). Upon activation, stimulates appetite and promotes growth hormone secretion (PubMed:10604470). Ghrelin binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:25605885). GHSR is coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:25605885). Also binds other growth hormone releasing peptides (GHRP) as well as non-peptide, low molecular weight secretagogues (PubMed:10604470). Also plays a role in synaptic plasticity independently of ghrelin by forming a heteromer with the dopamine receptors DRD1 and DRD2 in neurons (By similarity). Following DRD1 activation by dopamine in hippocampal neurons, GHSR acts as a coreceptor, resulting in DRD1 coupling to G(q) at the expense of G(s), initiating hippocampal synaptic plasticity involved in memory and learning (By similarity). Following DRD2 activation by dopamine in lumbosacral defecation centers, GHSR acts as a coreceptor, resulting in DRD1 coupling to G(q) at the expense of G(i)/G(o), regulating defecation (By similarity). {ECO:0000250|UniProtKB:Q99P50, ECO:0000269|PubMed:10604470, ECO:0000269|PubMed:25605885}.
uniprot
proteins
mass_dalton
40963
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10604470
uniprot
proteins
pubmed
25605885
uniprot
proteins
pubmed
9092793
uniprot
proteins
pubmed
9437732
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q92847}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q92847}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..65; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q92847"; TRANSMEM 72..95; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q92847"; TRANSMEM 117..138; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q92847"; TRANSMEM 162..182; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q92847"; TRANSMEM 211..234; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q92847"; TRANSMEM 262..283; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q92847"; TRANSMEM 301..324; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q92847
uniprot
proteins