Btla
entrez
407756
canonical
uniprot
Q6PNM1
canonical
ensembl
ENSRNOG00000030246
resolver
ensp
ENSRNOP00000076251
resolver
enst
ENSRNOT00000093151
resolver
genesymbol
Btla
resolver
uniprot
A0A1W2Q6H3
resolver
uniprot
Q569B2
resolver
uniprot_entry
A0A1W2Q6H3_RAT
resolver
uniprot_entry
BTLA_RAT
resolver
uniprot_sec
Q569B2
resolver
amino_acid_sequence
MKTVPAMLVTPRSFREFFILLLGLWSILCKEPTKRIGEECRVQLKIKRNSSRSAWTGELFKIECPVTYCVHRPNVTWCKHNGTRCVPLEVGPQLHTSWVENDQASAFVLYFEPIHLSDDGVYTCSANLNSEVINSHSVVIHVTERTQNCSEHPLITASDIPDATNASRPSTMEERPGRTWLLYALLPLGTSLLLLACVCLLCFLRRIQGKEKKPSDLAGRERETNLVDIPVSSRTNSQILTSETGIYDNDPWSSRLGESESTISSQLEGNKQGIVYASLNHCVIGRTPRQASKIQEAPTEYASICVRS
uniprot
proteins
function
FUNCTION: Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. {ECO:0000250|UniProtKB:Q7TSA3, ECO:0000250|UniProtKB:Q7Z6A9}.
uniprot
proteins
mass_dalton
34476
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11. {ECO:0000250}.; PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7TSA3, ECO:0000250|UniProtKB:Q7Z6A9}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 184..204; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins