HLA-DQA1
entrez
3117
canonical
uniprot
P01909
canonical
ensembl
ENSG00000196735
resolver
ensembl
ENSG00000206305
resolver
ensembl
ENSG00000228284
resolver
ensembl
ENSG00000232062
resolver
ensembl
ENSG00000257473
resolver
ensp
ENSP00000339398
resolver
ensp
ENSP00000364087
resolver
ensp
ENSP00000372738
resolver
ensp
ENSP00000378767
resolver
ensp
ENSP00000382583
resolver
ensp
ENSP00000382586
resolver
ensp
ENSP00000387892
resolver
ensp
ENSP00000392580
resolver
ensp
ENSP00000399068
resolver
ensp
ENSP00000404172
resolver
ensp
ENSP00000413237
resolver
ensp
ENSP00000414360
resolver
ensp
ENSP00000447257
resolver
ensp
ENSP00000787587
resolver
enst
ENST00000343139
resolver
enst
ENST00000374949
resolver
enst
ENST00000383251
resolver
enst
ENST00000395363
resolver
enst
ENST00000399675
resolver
enst
ENST00000399678
resolver
enst
ENST00000418023
resolver
enst
ENST00000420385
resolver
enst
ENST00000441297
resolver
enst
ENST00000444296
resolver
enst
ENST00000450614
resolver
enst
ENST00000456258
resolver
enst
ENST00000552745
resolver
genesymbol
HLA-DQA1
resolver
hgnc
HGNC:4942
resolver
uniprot
A0A173ADG5
resolver
uniprot
G4XQK4
resolver
uniprot
L8E864
resolver
uniprot
O19630
resolver
uniprot
O19706
resolver
uniprot
P01907
resolver
uniprot
P01908
resolver
uniprot
P04225
resolver
uniprot
P04226
resolver
uniprot
P05536
resolver
uniprot
P79553
resolver
uniprot
Q06751
resolver
uniprot
Q29876
resolver
uniprot
Q29994
resolver
uniprot
Q2Q6Y6
resolver
uniprot
Q2Q6Y7
resolver
uniprot
Q2Q6Y8
resolver
uniprot
Q2WCM3
resolver
uniprot
Q30063
resolver
uniprot
Q30064
resolver
uniprot
Q30067
resolver
uniprot
Q30068
resolver
uniprot
Q30070
resolver
uniprot
Q30071
resolver
uniprot
Q30072
resolver
uniprot
Q30073
resolver
uniprot
Q30086
resolver
uniprot
Q30101
resolver
uniprot
Q5Y7C6
resolver
uniprot
Q5Y7D5
resolver
uniprot
Q5Y7F5
resolver
uniprot
Q5Y7H0
resolver
uniprot
Q6ICU6
resolver
uniprot
Q6PR46
resolver
uniprot
Q6QDB1
resolver
uniprot
Q860W2
resolver
uniprot
Q860W4
resolver
uniprot
Q8MH44
resolver
uniprot
Q9BD37
resolver
uniprot
Q9TPM3
resolver
uniprot
Q9UM31
resolver
uniprot_entry
A0A173ADG5_HUMAN
resolver
uniprot_entry
DQA1_HUMAN
resolver
uniprot_entry
G4XQK4_HUMAN
resolver
uniprot_entry
L8E864_HUMAN
resolver
uniprot_entry
Q5Y7C6_HUMAN
resolver
uniprot_entry
Q5Y7H0_HUMAN
resolver
uniprot_entry
Q8MH44_HUMAN
resolver
uniprot_sec
O19630
resolver
uniprot_sec
O19706
resolver
uniprot_sec
P01907
resolver
uniprot_sec
P01908
resolver
uniprot_sec
P04225
resolver
uniprot_sec
P04226
resolver
uniprot_sec
P05536
resolver
uniprot_sec
P79553
resolver
uniprot_sec
Q06751
resolver
uniprot_sec
Q29876
resolver
uniprot_sec
Q29994
resolver
uniprot_sec
Q2Q6Y6
resolver
uniprot_sec
Q2Q6Y7
resolver
uniprot_sec
Q2Q6Y8
resolver
uniprot_sec
Q2WCM3
resolver
uniprot_sec
Q30063
resolver
uniprot_sec
Q30064
resolver
uniprot_sec
Q30067
resolver
uniprot_sec
Q30068
resolver
uniprot_sec
Q30070
resolver
uniprot_sec
Q30071
resolver
uniprot_sec
Q30072
resolver
uniprot_sec
Q30073
resolver
uniprot_sec
Q30086
resolver
uniprot_sec
Q30101
resolver
uniprot_sec
Q5Y7D5
resolver
uniprot_sec
Q5Y7F5
resolver
uniprot_sec
Q6ICU6
resolver
uniprot_sec
Q6PR46
resolver
uniprot_sec
Q6QDB1
resolver
uniprot_sec
Q860W2
resolver
uniprot_sec
Q860W4
resolver
uniprot_sec
Q9BD37
resolver
uniprot_sec
Q9TPM3
resolver
uniprot_sec
Q9UM31
resolver
amino_acid_sequence
MILNKALMLGALALTTVMSPCGGEDIVADHVASYGVNLYQSYGPSGQYTHEFDGDEQFYVDLGRKETVWCLPVLRQFRFDPQFALTNIAVLKHNLNSLIKRSNSTAATNEVPEVTVFSKSPVTLGQPNILICLVDNIFPPVVNITWLSNGHSVTEGVSETSFLSKSDHSFFKISYLTLLPSAEESYDCKVEHWGLDKPLLKHWEPEIPAPMSELTETVVCALGLSVGLVGIVVGTVFIIRGLRSVGASRHQGPL
uniprot
proteins
function
FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
uniprot
proteins
mass_dalton
27805
uniprot
proteins
protein_family
MHC class II family
uniprot
proteins
pubmed
10395113
uniprot
proteins
pubmed
11376336
uniprot
proteins
pubmed
11684289
uniprot
proteins
pubmed
1362295
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14769912
uniprot
proteins
pubmed
15020763
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15853899
uniprot
proteins
pubmed
16140993
uniprot
proteins
pubmed
16866887
uniprot
proteins
pubmed
17241953
uniprot
proteins
pubmed
17629515
uniprot
proteins
pubmed
18046453
uniprot
proteins
pubmed
19092054
uniprot
proteins
pubmed
19533806
uniprot
proteins
pubmed
2493052
uniprot
proteins
pubmed
2513578
uniprot
proteins
pubmed
2888727
uniprot
proteins
pubmed
3036828
uniprot
proteins
pubmed
3129499
uniprot
proteins
pubmed
3259543
uniprot
proteins
pubmed
3372263
uniprot
proteins
pubmed
3584986
uniprot
proteins
pubmed
3879967
uniprot
proteins
pubmed
6415485
uniprot
proteins
pubmed
6576979
uniprot
proteins
pubmed
6584734
uniprot
proteins
pubmed
6585297
uniprot
proteins
pubmed
6815651
uniprot
proteins
pubmed
8598037
uniprot
proteins
pubmed
8929711
uniprot
proteins
pubmed
9271631
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
uniprot
proteins
transmembrane_region
TRANSMEM 217..239; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins