St6galnac6
entrez
50935
canonical
uniprot
Q9JM95
canonical
ensembl
ENSMUSG00000026811
resolver
ensp
ENSMUSP00000092654
resolver
ensp
ENSMUSP00000092655
resolver
ensp
ENSMUSP00000108915
resolver
ensp
ENSMUSP00000115430
resolver
ensp
ENSMUSP00000239011
resolver
enst
ENSMUST00000095045
resolver
enst
ENSMUST00000113290
resolver
enst
ENSMUST00000131229
resolver
genesymbol
St6galnac6
resolver
genesymbol_syn
Siat7f
resolver
uniprot
A2AK72
resolver
uniprot
A2AK76
resolver
uniprot
A2AK77
resolver
uniprot
A2AK78
resolver
uniprot
A2AK79
resolver
uniprot
E9PU98
resolver
uniprot
E9PUI0
resolver
uniprot
Q05CN1
resolver
uniprot
Q8CDC3
resolver
uniprot
Q9R0G9
resolver
uniprot
Z4YLR0
resolver
uniprot_entry
E9PUI0_MOUSE
resolver
uniprot_entry
SIA7F_MOUSE
resolver
uniprot_entry
Z4YLR0_MOUSE
resolver
uniprot_sec
A2AK72
resolver
uniprot_sec
A2AK76
resolver
uniprot_sec
A2AK77
resolver
uniprot_sec
A2AK78
resolver
uniprot_sec
A2AK79
resolver
uniprot_sec
E9PU98
resolver
uniprot_sec
Q05CN1
resolver
uniprot_sec
Q8CDC3
resolver
uniprot_sec
Q9R0G9
resolver
amino_acid_sequence
MACSRPPSQCDPTTLPPGPPAGRWPLPFSRRRREMSSNKEQRSAVFVILFALITILILYSSNSANEVFHYGSLRGRTRRPVNLKKWSFSSAYFPILGNKTLPSRCNQCVIITSSSHLLGTKLGPEIERAECTIRMNDAPTSGYSADVGNKTTFRVVAHSSVFRVLRKPQEFVNRTPETVFIFWGPPNKMQKPQGSLLRVIQRAGLMFPNMEAYAVSPARMQQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPDYCSQRPRLQRMPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSHPSWT
uniprot
proteins
ec_number
2.4.99.-
uniprot
proteins
function
FUNCTION: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (PubMed:10702226). Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (By similarity). {ECO:0000250|UniProtKB:Q969X2, ECO:0000269|PubMed:10702226}.
uniprot
proteins
mass_dalton
38167
uniprot
proteins
protein_family
Glycosyltransferase 29 family
uniprot
proteins
pubmed
10702226
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15858074
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..64; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins