Acy3
entrez
293653
canonical
uniprot
Q5M876
canonical
ensembl
ENSRNOG00000017901
resolver
ensembl
ENSRNOG00055021463
resolver
ensembl
ENSRNOG00060006736
resolver
ensembl
ENSRNOG00060032656
resolver
ensembl
ENSRNOG00065032313
resolver
ensp
ENSRNOP00000024112
resolver
ensp
ENSRNOP00000110827
resolver
ensp
ENSRNOP00055029781
resolver
ensp
ENSRNOP00060008239
resolver
ensp
ENSRNOP00060046767
resolver
ensp
ENSRNOP00065045794
resolver
enst
ENSRNOT00000024112
resolver
enst
ENSRNOT00000133262
resolver
enst
ENSRNOT00055036666
resolver
enst
ENSRNOT00060011040
resolver
enst
ENSRNOT00060056601
resolver
enst
ENSRNOT00065055628
resolver
genesymbol
Acy3
resolver
uniprot
A0ABK0LWV3
resolver
uniprot_entry
A0ABK0LWV3_RAT
resolver
uniprot_entry
ACY3_RAT
resolver
amino_acid_sequence
MCSLPGSRKPLLRVAVTGGTHGNEMCGVYLARYWLQNPGELQRPSFSAMPVLANPAATAACRRYIDRDLNRTFTLTFLGSTATPDDPYEVKRAQELNQLLGPKGTCQAFDFILDLHNTTANTGACLISEVSQNPFNLHLCHYLQLQNPGLPCRLFQFEPPGTESYSMDSVSKNGISLELGPQPQGVLRAELFSQMRAMVASILDFIELFNQGMEFPAFEMEVYKNLGSVDFPRTTDGHLTGTVHSRLQDHDFEPLRPGEPIFKLFSGEDVLYEGDSVVYPLFVNEAAYYEKRVAFLKSEKIRISVPALPGLTPSSTQTP
uniprot
proteins
ec_number
3.5.1.114
uniprot
proteins
function
FUNCTION: Deacetylates N-acetyl aromatic amino acids and mercapturic acids (N-acetyl-L-cysteine-S-conjugates), including halogenated mercapturic acids derived from the metabolism of environmental contaminants such as trichloroethylene, making it a key enzyme in the processing of both endogenous and xenobiotic compounds. In neurons and blood vessels, deacetylates the mercapturates of 4-hydroxy-2-nonenal (4HNE) and acrolein (ACR), two highly reactive lipid peroxidation products; the resulting deacetylated products can then be transformed into toxic compounds by beta-lyase. {ECO:0000250|UniProtKB:Q91XE4}.
uniprot
proteins
mass_dalton
35419
uniprot
proteins
protein_family
AspA/AstE family
uniprot
proteins
protein_family
Aspartoacylase subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
319
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q91XE4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q91XE4}. Cytoplasm {ECO:0000250|UniProtKB:Q91XE4}. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm. {ECO:0000250|UniProtKB:Q91XE4}.
uniprot
proteins