Dut
entrez
110074
canonical
uniprot
Q9CQ43
canonical
ensembl
ENSMUSG00000027203
resolver
ensp
ENSMUSP00000057854
resolver
ensp
ENSMUSP00000080767
resolver
genesymbol
Dut
resolver
genesymbol_syn
Dutp
resolver
uniprot
Q8VCG1
resolver
uniprot
Q9JJ44
resolver
uniprot_entry
DUT_MOUSE
resolver
uniprot_sec
Q8VCG1
resolver
uniprot_sec
Q9JJ44
resolver
amino_acid_sequence
MPCSEDAAAVSASKRARAEDGASLRFVRLSEHATAPTRGSARAAGYDLFSAYDYTISPMEKAIVKTDIQIAVPSGCYGRVAPRSGLAVKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERISYPDLEEVQTLDDTERGSGGFGSTGKN
uniprot
proteins
ec_number
3.6.1.23
uniprot
proteins
function
FUNCTION: Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (By similarity). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (PubMed:30987342). {ECO:0000250|UniProtKB:P33316, ECO:0000250|UniProtKB:P70583, ECO:0000269|PubMed:30987342}.
uniprot
proteins
mass_dalton
17385
uniprot
proteins
pathway_participation
PATHWAY: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. {ECO:0000250|UniProtKB:P33316}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. {ECO:0000250|UniProtKB:P33316}.
uniprot
proteins
protein_family
DUTPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30987342
uniprot
proteins
sequence_length
162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P33316}.
uniprot
proteins