CSK
entrez
1445
canonical
uniprot
P41240
canonical
ensembl
ENSG00000103653
resolver
ensp
ENSP00000220003
resolver
ensp
ENSP00000414764
resolver
ensp
ENSP00000454906
resolver
ensp
ENSP00000528410
resolver
ensp
ENSP00000528411
resolver
ensp
ENSP00000528412
resolver
ensp
ENSP00000528413
resolver
ensp
ENSP00000528414
resolver
ensp
ENSP00000528415
resolver
ensp
ENSP00000528416
resolver
ensp
ENSP00000601205
resolver
ensp
ENSP00000622038
resolver
enst
ENST00000220003
resolver
enst
ENST00000439220
resolver
enst
ENST00000567571
resolver
enst
ENST00000858351
resolver
enst
ENST00000858352
resolver
enst
ENST00000858354
resolver
enst
ENST00000858355
resolver
enst
ENST00000858356
resolver
enst
ENST00000858357
resolver
enst
ENST00000931146
resolver
enst
ENST00000951979
resolver
genesymbol
CSK
resolver
hgnc
HGNC:2444
resolver
uniprot
A8K3B6
resolver
uniprot
B2R6Q4
resolver
uniprot
Q2M3N2
resolver
uniprot
Q6FGZ6
resolver
uniprot_entry
A8K3B6_HUMAN
resolver
uniprot_entry
B2R6Q4_HUMAN
resolver
uniprot_entry
CSK_HUMAN
resolver
uniprot_sec
Q2M3N2
resolver
uniprot_sec
Q6FGZ6
resolver
amino_acid_sequence
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
uniprot
proteins
ec_number
2.7.10.4
uniprot
proteins
function
FUNCTION: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. May act as a negative regulator of EGFR and STAT3 signaling pathways (PubMed:26918609). {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:26918609, ECO:0000269|PubMed:9281320}.
uniprot
proteins
mass_dalton
50704
uniprot
proteins
mutagenesis
MUTAGEN 184; /note="Y->F: Abolishes phosphorylation."; /evidence="ECO:0000269|PubMed:9148770"; MUTAGEN 304; /note="Y->F: Decreases activity by two-thirds and alters conformation."; /evidence="ECO:0000269|PubMed:9148770"; MUTAGEN 364; /note="S->A: Strong decrease of phosphorylation by PRKACA (catalytic subunit of PKA)."; /evidence="ECO:0000269|PubMed:11181701
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated. {ECO:0000269|PubMed:11181701, ECO:0000269|PubMed:9148770}.
uniprot
proteins
protein_family
CSK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10790433
uniprot
proteins
pubmed
10838081
uniprot
proteins
pubmed
11181701
uniprot
proteins
pubmed
11433379
uniprot
proteins
pubmed
1371489
uniprot
proteins
pubmed
14610046
uniprot
proteins
pubmed
15208781
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16243715
uniprot
proteins
pubmed
1639064
uniprot
proteins
pubmed
1720539
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17525734
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
1945408
uniprot
proteins
pubmed
19888460
uniprot
proteins
pubmed
20851766
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21930792
uniprot
proteins
pubmed
23526378
uniprot
proteins
pubmed
26918609
uniprot
proteins
pubmed
7511113
uniprot
proteins
pubmed
7683130
uniprot
proteins
pubmed
7683131
uniprot
proteins
pubmed
9148770
uniprot
proteins
pubmed
9281320
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P41241}. Cell membrane {ECO:0000250|UniProtKB:P41241}. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250|UniProtKB:P41241}.
uniprot
proteins