Mkln1
entrez
27418
canonical
uniprot
O89050
canonical
ensembl
ENSMUSG00000025609
resolver
ensp
ENSMUSP00000026699
resolver
ensp
ENSMUSP00000252880
resolver
enst
ENSMUST00000026699
resolver
genesymbol
Mkln1
resolver
uniprot
Q3UWT3
resolver
uniprot_entry
MKLN1_MOUSE
resolver
uniprot_entry
Q3UWT3_MOUSE
resolver
amino_acid_sequence
MAAGGAVAVAPECRLLPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDMHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQATKDNLSKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIRKHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL
uniprot
proteins
function
FUNCTION: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation (PubMed:21482357). Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (PubMed:18710924, PubMed:9724633). {ECO:0000250|UniProtKB:Q9UL63, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:21482357, ECO:0000269|PubMed:9724633}.
uniprot
proteins
mass_dalton
84878
uniprot
proteins
mutagenesis
MUTAGEN 182..183; /note="KH->AA: Abolishes targeting to the nucleus."; /evidence="ECO:0000269|PubMed:18710924"; MUTAGEN 701..735; /note="Missing: Strongly increased location in the nucleus."; /evidence="ECO:0000269|PubMed:18710924"; MUTAGEN 723; /note="T->A: No effect on predominant location in the cytosol."; /evidence="ECO:0000269|PubMed:18710924"; MUTAGEN 723; /note="T->D: Strongly increased location in the nucleus."; /evidence="ECO:0000269|PubMed:18710924
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18710924
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21482357
uniprot
proteins
pubmed
25372678
uniprot
proteins
pubmed
9724633
uniprot
proteins
sequence_length
735
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9724633}. Cytoplasm, cytosol {ECO:0000269|PubMed:18710924}. Nucleus, nucleoplasm {ECO:0000269|PubMed:18710924}. Cell projection, ruffle {ECO:0000269|PubMed:9724633}. Cytoplasm, cell cortex {ECO:0000269|PubMed:9724633}. Synapse {ECO:0000269|PubMed:21482357}. Postsynapse {ECO:0000269|PubMed:21482357}. Note=Colocalizes with GABRA1 at synapses and in postsynaptic regions (PubMed:21482357). Colocalizes with actin fibers in the cell cortex. {ECO:0000269|PubMed:21482357, ECO:0000269|PubMed:9724633}.
uniprot
proteins