Trim69
entrez
311373
canonical
uniprot
Q5BK82
canonical
ensembl
ENSRNOG00000017157
resolver
ensembl
ENSRNOG00055003255
resolver
ensembl
ENSRNOG00060016141
resolver
ensembl
ENSRNOG00065027629
resolver
ensp
ENSRNOP00000023209
resolver
ensp
ENSRNOP00000111864
resolver
ensp
ENSRNOP00055003755
resolver
ensp
ENSRNOP00060022215
resolver
ensp
ENSRNOP00065039079
resolver
enst
ENSRNOT00000135410
resolver
enst
ENSRNOT00055005053
resolver
enst
ENSRNOT00060027658
resolver
enst
ENSRNOT00065047647
resolver
genesymbol
Trim69
resolver
genesymbol_syn
Rnf36
resolver
uniprot_entry
TRI69_RAT
resolver
amino_acid_sequence
MEVSSRPPSNFDPGNYVEVSDPSTHLPSKVVIQDITTELHCPLCNDWFRDPLMLTCGHNFCQACIQNYWKMQAKETFCPECKMLCQYSNCTFNLVLEKLVEKIKRLPLLKGHPQCPEHGENLKLFSKPDGKMICFQCKDARLSMGQSKDFLQISEAVRFFTEELAIYQSQLQTTLKELQSLRTMQKDAIAAYKDNKIQLQQNLSLEFLKLHQFLHNKEKDILNDLRDEGKVLNEEMDANLNQIQEQCLLAKDMLANIQARMEQQNSFDFLTDITKLLENMEKGMKTLVPRQLISKKLSLGRFKGPIQYTIWREMQSILSPGPSQLTLDPKTAHPNLVLSNSRTSVCHGDVKQVMPDDPERFDSSVAVLGSKGFTSGKWYWEIEVAKKTKWTIGIVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSCSLNLGDLRRVGVYLDYEGGQVSFYNATNMTHLYTFTSVFLEKLFPYLCPCLNDGGENKEPLHIVHPQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins, thereby limiting infection. Also involved in antiviral immunity by mediating 'Lys-63'-linked ubiquitination of STING1, thereby promoting STING1 dimerization and downstream activation of cGAS-STING signaling. In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity. Also plays a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination. Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1. {ECO:0000250|UniProtKB:Q86WT6}.
uniprot
proteins
mass_dalton
57215
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q86WT6}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation is necessary for nuclear localization. {ECO:0000250|UniProtKB:Q80X56}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86WT6}. Nucleus {ECO:0000250|UniProtKB:Q86WT6}. Nucleus speckle {ECO:0000250|UniProtKB:Q86WT6}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q86WT6}. Note=Adopts a filamentous distribution in the cell cytoplasm where it strongly colocalizes with stable microtubules. {ECO:0000250|UniProtKB:Q86WT6}.
uniprot
proteins