Ddr2
entrez
18214
canonical
uniprot
Q62371
canonical
ensembl
ENSMUSG00000026674
resolver
ensp
ENSMUSP00000027985
resolver
ensp
ENSMUSP00000129624
resolver
ensp
ENSMUSP00000141443
resolver
enst
ENSMUST00000027985
resolver
enst
ENSMUST00000170800
resolver
enst
ENSMUST00000194690
resolver
genesymbol
Ddr2
resolver
genesymbol_syn
Ntrkr3
resolver
genesymbol_syn
Tkt
resolver
genesymbol_syn
Tyro10
resolver
uniprot
B2RSD7
resolver
uniprot_entry
DDR2_MOUSE
resolver
uniprot_sec
B2RSD7
resolver
activity_regulation
ACTIVITY REGULATION: Present in an inactive state in the absence of collagen binding and phosphorylation by SRC. Tyrosine phosphorylation enhances the affinity for ATP and the catalytic activity.
uniprot
proteins
amino_acid_sequence
MIPIPRMPLVLLLLLLILGSAKAQVNPAICRYPLGMSGGHIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVQPDDLKEFLQIDLRTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGSRWISWRNRHGKQVLDGNSNPYDVFLKDLEPPIVARFVRLIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGFIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPTAVYFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSGALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSESSMFNNNRSSSPSEQESNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPAQPNGPEGVPHYAEADIVNLQGVTGGNTYCVPAVTMDLLSGKDVAVEEFPRKLLAFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVCITEDPLCMITEYMENGDLNQFLSRHEPLSSCSSDATVSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQIYLPQPALCPDSVYKLMLSCWRRETKHRPSFQEIHLLLLQQGAE
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Ddr2 are the cause of the smallie (sli) phenotype. Smallie mice show distinct dwarfing, with reduced body mass and reduced bone mineral content. Mice also have mild craniofacial deformities, such as protuberant eyes and snub noses. Smallie mice have a reduced life span, with about half of them dying within 6 months. Matings between male and female smallie mice do not yield any offspring. The levels of circulating steroid hormones remain at a level corresponding to prepubertal wild-type mice. Adult testes exhibit much reduced numbers of spermatids with atrophy of spermatogonia, Sertoli and Leydig cells. Ovaries show an absence of corpora lutea.
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. {ECO:0000269|PubMed:11375938, ECO:0000269|PubMed:11723120, ECO:0000269|PubMed:11884411, ECO:0000269|PubMed:15509586, ECO:0000269|PubMed:19681157}.
uniprot
proteins
mass_dalton
96482
uniprot
proteins
mutagenesis
MUTAGEN 471; /note="Y->F: Reduces tyrosine phosphorylation by 90%; when associated with E-608."; /evidence="ECO:0000269|PubMed:11884411"; MUTAGEN 608; /note="K->E: Abolishes kinase activity. Reduces tyrosine phosphorylation by 90%; when associated with F-471."; /evidence="ECO:0000269|PubMed:11884411
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250}.; PTM: Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC; this is required for activation and subsequent autophosphorylation on additional tyrosine residues (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Insulin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
11375938
uniprot
proteins
pubmed
11723120
uniprot
proteins
pubmed
11884411
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15509586
uniprot
proteins
pubmed
18483174
uniprot
proteins
pubmed
19681157
uniprot
proteins
pubmed
8108131
uniprot
proteins
pubmed
8247548
uniprot
proteins
sequence_length
854
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 400..421; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins