NKX2-2
entrez
4821
canonical
uniprot
O95096
canonical
ensembl
ENSG00000125820
resolver
ensp
ENSP00000366347
resolver
enst
ENST00000377142
resolver
genesymbol
NKX2-2
resolver
genesymbol_syn
NKX2.2
resolver
genesymbol_syn
NKX2B
resolver
hgnc
HGNC:7835
resolver
uniprot_entry
NKX22_HUMAN
resolver
amino_acid_sequence
MSLTNTKTGFSVKDILDLPDTNDEEGSVAEGPEEENEGPEPAKRAGPLGQGALDAVQSLPLKNPFYDSSDNPYTRWLASTEGLQYSLHGLAAGAPPQDSSSKSPEPSADESPDNDKETPGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW
uniprot
proteins
function
FUNCTION: Transcriptional activator involved in the development of insulin-producing beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). {ECO:0000250|UniProtKB:P42586}.
uniprot
proteins
mass_dalton
30133
uniprot
proteins
protein_family
NK-2 homeobox family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9703340
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
uniprot
proteins