Rpsa
entrez
16785
canonical
uniprot
P14206
canonical
ensembl
ENSMUSG00000032518
resolver
ensp
ENSMUSP00000035105
resolver
ensp
ENSMUSP00000148933
resolver
enst
ENSMUST00000035105
resolver
enst
ENSMUST00000217317
resolver
genesymbol
Rpsa
resolver
genesymbol_syn
Lamr1
resolver
genesymbol_syn
P40-8
resolver
uniprot
Q58E74
resolver
uniprot
Q8BHL0
resolver
uniprot
Q8BNL2
resolver
uniprot
Q91V31
resolver
uniprot
Q9CY13
resolver
uniprot_entry
RSSA_MOUSE
resolver
uniprot_sec
Q58E74
resolver
uniprot_sec
Q8BHL0
resolver
uniprot_sec
Q8BNL2
resolver
uniprot_sec
Q91V31
resolver
uniprot_sec
Q9CY13
resolver
amino_acid_sequence
MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTAAQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTEWS
uniprot
proteins
function
FUNCTION: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA (By similarity). Enables malignant tumor cells to penetrate laminin tissue and vessel barriers. Activates precursor thymic anti-OFA/iLRP specific cytotoxic T-cell. May induce CD8 T-suppressor cells secreting IL-10. {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:10697612, ECO:0000269|PubMed:1374897, ECO:0000269|PubMed:16453457, ECO:0000269|PubMed:6301485, ECO:0000269|PubMed:6302102}.
uniprot
proteins
mass_dalton
32838
uniprot
proteins
post_translational_modification
PTM: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association. {ECO:0000255|HAMAP-Rule:MF_03016}.; PTM: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions. {ECO:0000255|HAMAP-Rule:MF_03016}.
uniprot
proteins
protein_family
Universal ribosomal protein uS2 family
uniprot
proteins
pubmed
10697612
uniprot
proteins
pubmed
11597123
uniprot
proteins
pubmed
11689427
uniprot
proteins
pubmed
1374897
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16453457
uniprot
proteins
pubmed
18339329
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
2531008
uniprot
proteins
pubmed
3357791
uniprot
proteins
pubmed
36517592
uniprot
proteins
pubmed
6301485
uniprot
proteins
pubmed
6302102
uniprot
proteins
pubmed
8954992
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane. Cytoplasm {ECO:0000269|PubMed:36517592}. Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Colocalizes with PPP1R16B in the cell membrane (By similarity). 37LRP shuttles to the nucleus upon midkine (MDK) binding. {ECO:0000255|HAMAP-Rule:MF_03016}.
uniprot
proteins