CBY1
entrez
25776
canonical
uniprot
Q9Y3M2
canonical
ensembl
ENSG00000100211
resolver
ensp
ENSP00000216029
resolver
ensp
ENSP00000380026
resolver
ensp
ENSP00000412260
resolver
ensp
ENSP00000413934
resolver
ensp
ENSP00000537997
resolver
ensp
ENSP00000537998
resolver
ensp
ENSP00000538000
resolver
ensp
ENSP00000538001
resolver
ensp
ENSP00000538002
resolver
ensp
ENSP00000538003
resolver
ensp
ENSP00000538004
resolver
ensp
ENSP00000538005
resolver
ensp
ENSP00000538006
resolver
ensp
ENSP00000538008
resolver
ensp
ENSP00000538009
resolver
ensp
ENSP00000538011
resolver
ensp
ENSP00000538012
resolver
ensp
ENSP00000600775
resolver
ensp
ENSP00000600778
resolver
ensp
ENSP00000600779
resolver
ensp
ENSP00000600781
resolver
ensp
ENSP00000600782
resolver
ensp
ENSP00000600783
resolver
ensp
ENSP00000623642
resolver
ensp
ENSP00000623643
resolver
ensp
ENSP00000623644
resolver
ensp
ENSP00000623645
resolver
ensp
ENSP00000623646
resolver
ensp
ENSP00000623647
resolver
ensp
ENSP00000623648
resolver
enst
ENST00000216029
resolver
enst
ENST00000396811
resolver
enst
ENST00000411557
resolver
enst
ENST00000416285
resolver
enst
ENST00000867938
resolver
enst
ENST00000867939
resolver
enst
ENST00000867941
resolver
enst
ENST00000867942
resolver
enst
ENST00000867943
resolver
enst
ENST00000867944
resolver
enst
ENST00000867945
resolver
enst
ENST00000867946
resolver
enst
ENST00000867947
resolver
enst
ENST00000867949
resolver
enst
ENST00000867950
resolver
enst
ENST00000867952
resolver
enst
ENST00000867953
resolver
enst
ENST00000930716
resolver
enst
ENST00000930719
resolver
enst
ENST00000930720
resolver
enst
ENST00000930722
resolver
enst
ENST00000930723
resolver
enst
ENST00000930724
resolver
enst
ENST00000953583
resolver
enst
ENST00000953584
resolver
enst
ENST00000953585
resolver
enst
ENST00000953586
resolver
enst
ENST00000953587
resolver
enst
ENST00000953588
resolver
enst
ENST00000953589
resolver
genesymbol
CBY1
resolver
genesymbol_syn
ARB1
resolver
genesymbol_syn
C22orf2
resolver
genesymbol_syn
CBY
resolver
genesymbol_syn
PGEA1
resolver
hgnc
HGNC:1307
resolver
uniprot
B2R4S2
resolver
uniprot
Q66GT6
resolver
uniprot
Q9UIK9
resolver
uniprot_entry
CBY1_HUMAN
resolver
uniprot_sec
B2R4S2
resolver
uniprot_sec
Q66GT6
resolver
uniprot_sec
Q9UIK9
resolver
amino_acid_sequence
MPFFGNTFSPKKTPPRKSASLSNLHSLDRSTREVELGLEYGSPTMNLAGQSLKFENGQWIAETGVSGGVDRREVQRLRRRNQQLEEENNLLRLKVDILLDMLSESTAESHLMEKELDELRISRKRK
uniprot
proteins
function
FUNCTION: Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors (PubMed:12712206, PubMed:19435523). Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins (PubMed:15194699). Promotes adipocyte and cardiomyocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q9D1C2, ECO:0000269|PubMed:12712206, ECO:0000269|PubMed:15194699, ECO:0000269|PubMed:19435523}.
uniprot
proteins
mass_dalton
14470
uniprot
proteins
mutagenesis
MUTAGEN 77; /note="L->A: No effect on homodimerization, nuclear localization and interaction with CTNNB1 but a slight reduction in interaction with KPNA4. Loss of homodimerization, reduced nuclear localization, significant reduction in interaction with KPNA4 but no effect on interaction with CTNNB1; when associated with A-91. Loss of homodimerization; when associated with A-84 or A-98. Loss of homodimerization but no effect on interaction with CTNNB1; when associated with A-84; A-91 and A-98."; /evidence="ECO:0000269|PubMed:19435523"; MUTAGEN 84; /note="L->A: Reduced homodimerization. Loss of homodimerization; when associated with A-77 or A-91 or A-98 or A-77; A-91 and A-98."; /evidence="ECO:0000269|PubMed:19435523"; MUTAGEN 91; /note="L->A: No effect homodimerization, nuclear localization and interaction with CTNNB1 but a slight reduction in interaction with KPNA4. Loss of homodimerization, reduced nuclear localization, significant reduction in interaction with KPNA4 but no effect on interaction with CTNNB1; when associated with A-77. Loss of homodimerization; when associated with A-84 or A-98. Loss of homodimerization but no effect on interaction with CTNNB1; when associated with A-77; A-84 and A-98."; /evidence="ECO:0000269|PubMed:19435523"; MUTAGEN 98; /note="L->A: No effect on its homodimerization. Loss of homodimerization; when associated with A-77 or A-84 or A-91 or A-77; A-84 and A-91."; /evidence="ECO:0000269|PubMed:19435523
uniprot
proteins
protein_family
Chibby family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12529303
uniprot
proteins
pubmed
12712206
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15194699
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16424001
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19435523
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27528616
uniprot
proteins
pubmed
30395363
uniprot
proteins
sequence_length
126
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:16424001}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27528616, ECO:0000269|PubMed:30395363}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:27528616}. Golgi apparatus. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:16424001}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9D1C2}. Cytoplasm {ECO:0000269|PubMed:19435523}. Nucleus {ECO:0000269|PubMed:19435523}.
uniprot
proteins