Fkbp8
entrez
14232
canonical
uniprot
O35465
canonical
ensembl
ENSMUSG00000019428
resolver
ensp
ENSMUSP00000074935
resolver
ensp
ENSMUSP00000112527
resolver
ensp
ENSMUSP00000114069
resolver
ensp
ENSMUSP00000203087
resolver
ensp
ENSMUSP00000203119
resolver
ensp
ENSMUSP00000203143
resolver
genesymbol
Fkbp8
resolver
genesymbol_syn
Fkbp38
resolver
genesymbol_syn
Sam11
resolver
uniprot
Q3UK86
resolver
uniprot
Q6GTX9
resolver
uniprot
Q811M7
resolver
uniprot
Q811R4
resolver
uniprot
Q8C2F0
resolver
uniprot
Q99L93
resolver
uniprot_entry
FKBP8_MOUSE
resolver
uniprot_sec
Q3UK86
resolver
uniprot_sec
Q6GTX9
resolver
uniprot_sec
Q811M7
resolver
uniprot_sec
Q811R4
resolver
uniprot_sec
Q8C2F0
resolver
uniprot_sec
Q99L93
resolver
amino_acid_sequence
MASWAEPSEPAALRLPGAPLLEGFEVLDGVDDAEEEDDLSGLPPLEDMGQPTVEEAEQPGALAREFLAATEPEPAPAPAPEEWLDILGNGLLRMKTLVPGPKGSSRPLKGQVVTVHLQMSLENGTRVQEEPELAFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYGPQGRSPYIPPHAALCLEVTLKTAEDGPDLEMLSGQERVALANRKRECGNAHYQRADFVLAANSYDLAIKAITSNTKVDMTCEEEEELLQLKVKCLNNLAASQLKLDHYRAALRSCSQVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKRAAQRSTETALYRKMLGNPSRLPAKCPGKGAWSIPWKWLFGATAVALGGVALSVVIAARN
uniprot
proteins
ec_number
5.2.1.8
uniprot
proteins
function
FUNCTION: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). Required for normal embryonic development. {ECO:0000250}.
uniprot
proteins
mass_dalton
43529
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. {ECO:0000250|UniProtKB:Q14318}.
uniprot
proteins
pubmed
10197430
uniprot
proteins
pubmed
12510191
uniprot
proteins
pubmed
14667822
uniprot
proteins
pubmed
15105374
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18459960
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
402
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:15105374}; Single-pass membrane protein {ECO:0000269|PubMed:15105374}; Cytoplasmic side {ECO:0000269|PubMed:15105374}.
uniprot
proteins
transmembrane_region
TRANSMEM 380..400; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins