Nxn
entrez
18230
canonical
uniprot
P97346
canonical
ensembl
ENSMUSG00000020844
resolver
ensp
ENSMUSP00000021204
resolver
genesymbol
Nxn
resolver
genesymbol_syn
Gn25
resolver
uniprot
Q5H8T6
resolver
uniprot
Q5H8U0
resolver
uniprot
Q99KF3
resolver
uniprot_entry
NXN_MOUSE
resolver
uniprot_sec
Q5H8T6
resolver
uniprot_sec
Q5H8U0
resolver
uniprot_sec
Q99KF3
resolver
amino_acid_sequence
MSGFLEELLGDKLVTGGGEEVDVHSLGARGIALLGLYFGCSLSAPCAQLSASLAAFYGRLRGDAAAGPGAGAGAGAAAEPEPRHRLEIVFVSSDQDQRQWQDFVRDMPWLALPYKEKHRKLKLWNKYRVSNIPSLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQEFEIIFVSADRSEESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIVLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAVQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVETFVNDFLAEKLKPEPI
uniprot
proteins
ec_number
1.8.1.8
uniprot
proteins
function
FUNCTION: Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A). {ECO:0000269|PubMed:10903915, ECO:0000269|PubMed:16604061, ECO:0000269|PubMed:16764867, ECO:0000269|PubMed:20970343}.
uniprot
proteins
mass_dalton
48344
uniprot
proteins
mutagenesis
MUTAGEN 205; /note="C->S: Loss of function and interaction with DVL1; when associated with S-208."; /evidence="ECO:0000269|PubMed:16604061"; MUTAGEN 208; /note="C->S: Loss of function and interaction with DVL1; when associated with S-205."; /evidence="ECO:0000269|PubMed:16604061
uniprot
proteins
protein_family
Nucleoredoxin family
uniprot
proteins
pubmed
10903915
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15670764
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16604061
uniprot
proteins
pubmed
16764867
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20970343
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9119370
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16604061}. Nucleus {ECO:0000269|PubMed:10903915, ECO:0000269|PubMed:9119370}.
uniprot
proteins