HEY1
entrez
23462
canonical
uniprot
Q9Y5J3
canonical
ensembl
ENSG00000164683
resolver
ensp
ENSP00000338272
resolver
ensp
ENSP00000346761
resolver
genesymbol
HEY1
resolver
genesymbol_syn
BHLHB31
resolver
genesymbol_syn
CHF2
resolver
genesymbol_syn
HERP2
resolver
genesymbol_syn
HESR1
resolver
genesymbol_syn
HRT1
resolver
hgnc
HGNC:4880
resolver
uniprot
B2R883
resolver
uniprot
B4DEI9
resolver
uniprot
Q5TZS3
resolver
uniprot
Q8NAM2
resolver
uniprot
Q9NYP4
resolver
uniprot_entry
B4DEI9_HUMAN
resolver
uniprot_entry
HEY1_HUMAN
resolver
uniprot_sec
B2R883
resolver
uniprot_sec
Q5TZS3
resolver
uniprot_sec
Q8NAM2
resolver
uniprot_sec
Q9NYP4
resolver
amino_acid_sequence
MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTEIGAF
uniprot
proteins
function
FUNCTION: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). {ECO:0000250|UniProtKB:Q9WV93, ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:15485867, ECO:0000269|PubMed:25985737}.
uniprot
proteins
mass_dalton
32613
uniprot
proteins
protein_family
HEY family
uniprot
proteins
pubmed
10403790
uniprot
proteins
pubmed
10415358
uniprot
proteins
pubmed
10692439
uniprot
proteins
pubmed
10860664
uniprot
proteins
pubmed
11095750
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15485867
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
25985737
uniprot
proteins
pubmed
26068074
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:26068074}.
uniprot
proteins