Nlrx1
entrez
315599
canonical
uniprot
Q5FVQ8
canonical
ensembl
ENSRNOG00000052386
resolver
ensembl
ENSRNOG00065023369
resolver
ensp
ENSRNOP00000071934
resolver
ensp
ENSRNOP00065032476
resolver
enst
ENSRNOT00000077958
resolver
enst
ENSRNOT00065039952
resolver
genesymbol
Nlrx1
resolver
uniprot_entry
NLRX1_RAT
resolver
amino_acid_sequence
MRWGCHLPRTSWGSGLGRTVPLPDELRIQSSWPFKGVHHPLRPPRAFIRHHGNSADSAPPPGRHGQLFRSISATEAIQRHRRNLTEWFSRLPREERQFGPTFALDTVHVDPVIRESTPDDLLRPSTELATGHQRTQAELPPLALSQLFDPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGSTPASLCQLVTQRYTPLKEVLPLMNAAGSRLLFVLHGLERLNLDFRLAGTGLCSDPEEPGAPAAIMVNLLRKYMLPEASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPDCGYGAGGTGVSVTPAQRDNLIQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTSAGQTLTSIYTSFLRLNFNGETLDSTDPSNLSLMSYAARTMGKLAYEGVSSRKTYFSEEDVRGCLEAGIKTEEEFQLLQIFRRDALRFFLAPCVEPGHLGTFVFTVPAMQEYLAALYIVLGLRKTALQRVGKEVFEFVGRVGEDVSLVLGIVAKLLPLRILPLLFNLLKVVPRVFGRMVSKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHPDEPPEDEVFELFPMFMSGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKMGRQVLPPSELLDHLFFHYEFQNQRFSAEVLGSLRQLNLAGVRMTPLKCTVVASVLGSGRHPLDEVNLASCQLDPAGLHTLMPVLLRARKLGLQLNNLGPEACRDLRDLLLHDQCQITTLRLSNNPLTAAGVGVLMDGLAGNTSVTHLSLLHTDLGDEGLELLAAQLDRNKQLQELNVAYNGAGDTVALALAKAARKHPSLELLHLYFNELSSEGRQVLRDLGGSGEGGARVVASLTEGTAVSEYWSVILSEVQRNLNSWDPVRVQRHLKLLLRDLEDSRGATLNPWRKAQLLRVESEVKTLLEQLGGSGH
uniprot
proteins
function
FUNCTION: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (By similarity). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner. In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity). {ECO:0000250|UniProtKB:Q3TL44, ECO:0000250|UniProtKB:Q86UT6}.
uniprot
proteins
mass_dalton
107590
uniprot
proteins
protein_family
NLRP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
973
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q86UT6}.
uniprot
proteins