CDT1
entrez
81620
canonical
uniprot
Q9H211
canonical
ensembl
ENSG00000167513
resolver
ensp
ENSP00000301019
resolver
enst
ENST00000301019
resolver
genesymbol
CDT1
resolver
hgnc
HGNC:24576
resolver
uniprot
Q86XX9
resolver
uniprot
Q96CJ5
resolver
uniprot
Q96GK5
resolver
uniprot
Q96H67
resolver
uniprot
Q96HE6
resolver
uniprot
Q9BWM0
resolver
uniprot_entry
CDT1_HUMAN
resolver
uniprot_sec
Q86XX9
resolver
uniprot_sec
Q96CJ5
resolver
uniprot_sec
Q96GK5
resolver
uniprot_sec
Q96H67
resolver
uniprot_sec
Q96HE6
resolver
uniprot_sec
Q9BWM0
resolver
amino_acid_sequence
MEQRRVTDFFARRRPGPPRIAPPKLACRTPSPARPALRAPASATSGSRKRARPPAAPGRDQARPPARRRLRLSVDEVSSPSTPEAPDIPACPSPGQKIKKSTPAAGQPPHLTSAQDQDTISELASCLQRARELGARVRALKASAQDAGESCTPEAEGRPEEPCGEKAPAYQRFHALAQPGLPGLVLPYKYQVLAEMFRSMDTIVGMLHNRSETPTFAKVQRGVQDMMRRRFEECNVGQIKTVYPASYRFRQERSVPTFKDGTRRSDYQLTIEPLLEQEADGAAPQLTASRLLQRRQIFSQKLVEHVKEHHKAFLASLSPAMVVPEDQLTRWHPRFNVDEVPDIEPAALPQPPATEKLTTAQEVLARARNLISPRMEKALSQLALRSAAPSSPGSPRPALPATPPATPPAASPSALKGVSQDLLERIRAKEAQKQLAQMTRCPEQEQRLQRLERLPELARVLRSVFVSERKPALSMEVACARMVGSCCTIMSPGEMEKHLLLLSELLPDWLSLHRIRTDTYVKLDKAADLAHITARLAHQTRAEEGL
uniprot
proteins
disease_involvement
DISEASE: Meier-Gorlin syndrome 4 (MGORS4) [MIM:613804]: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. {ECO:0000269|PubMed:21358631, ECO:0000269|PubMed:21358632}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}.
uniprot
proteins
mass_dalton
60390
uniprot
proteins
mutagenesis
MUTAGEN 68..70; /note="RRL->AAA: Abolishes binding of cyclin A-dependent protein kinases."; /evidence="ECO:0000269|PubMed:14993212"; MUTAGEN 170; /note="Y->A: Alters interaction with GMNN."; /evidence="ECO:0000269|PubMed:21543332
uniprot
proteins
post_translational_modification
PTM: Two independent E3 ubiquitin ligase complexes, SCF(SKP2) and the DCX(DTL) complex, mediated CDT1 degradation in S phase (PubMed:14993212, PubMed:16861906, PubMed:16949367, PubMed:17085480). Ubiquitinated by the DCX(DTL) complex, in response to DNA damage, leading to its degradation (PubMed:16861906, PubMed:17085480). Ubiquitination by the DCX(DTL) complex is necessary to ensure proper cell cycle regulation and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation (PubMed:16861906, PubMed:17085480). Phosphorylation at Thr-29 by CDK2 targets CDT1 for ubiquitination by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation (PubMed:14993212). The interaction with GMNN protects it against ubiquitination (PubMed:15257290). Deubiquitinated by USP37 (PubMed:27296872). Ubiquitinated and degraded by the SCF(FBXO31) complex during the G2 phase to prevent re-replication (PubMed:24828503). {ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:15257290, ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:24828503, ECO:0000269|PubMed:27296872}.; PTM: Phosphorylation by cyclin A-dependent kinases at Thr-29 targets CDT1 for ubiquitynation by SCF(SKP2) E3 ubiquitin ligase and subsequent degradation (PubMed:14993212). Phosphorylated at Thr-29 by MAPK8/JNK1, which blocks replication licensing in response to stress (PubMed:21856198). Binding to GMNN is not affected by phosphorylation. {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22645314}.
uniprot
proteins
protein_family
Cdt1 family
uniprot
proteins
pubmed
10766248
uniprot
proteins
pubmed
11125146
uniprot
proteins
pubmed
14672932
uniprot
proteins
pubmed
14990995
uniprot
proteins
pubmed
14993212
uniprot
proteins
pubmed
15257290
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16861906
uniprot
proteins
pubmed
16949367
uniprot
proteins
pubmed
17085480
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18832067
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21358631
uniprot
proteins
pubmed
21358632
uniprot
proteins
pubmed
21543332
uniprot
proteins
pubmed
21856198
uniprot
proteins
pubmed
22581055
uniprot
proteins
pubmed
22645314
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24828503
uniprot
proteins
pubmed
25990725
uniprot
proteins
pubmed
26842564
uniprot
proteins
pubmed
27296872
uniprot
proteins
sequence_length
546
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:26842564}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:22581055}. Note=Transiently localizes to kinetochores during prometaphase and metaphase. {ECO:0000269|PubMed:22581055}.
uniprot
proteins