Alkbh8
entrez
67667
canonical
uniprot
Q80Y20
canonical
ensembl
ENSMUSG00000025899
resolver
ensp
ENSMUSP00000061511
resolver
ensp
ENSMUSP00000230665
resolver
ensp
ENSMUSP00000230672
resolver
genesymbol
Alkbh8
resolver
uniprot
Q3TUG4
resolver
uniprot
Q8BV08
resolver
uniprot
Q9CX44
resolver
uniprot_entry
ALKB8_MOUSE
resolver
uniprot_sec
Q3TUG4
resolver
uniprot_sec
Q8BV08
resolver
uniprot_sec
Q9CX44
resolver
amino_acid_sequence
MNINHKGVLKLTKMEKKFLRKQSKARHVLLKHEGIQAVSYPTQSLVIANGGLGNGVSRKQLLLTLEKCGPVEALLMPPNKPYAFVIFQTIEESKKAYFTLNGKEIIDDLGQKIFLYLNFVEKAQWKNMGLEALPPGLLVVEEIISSEEEKKLLESVNWTEDTGNQNFQRSLKHRRVKHFGYEFHYESNTVDKDKPLPGGLPEVCSSILEKLLKEGYIKHKPDQLTINQYEPGHGIPAHIDTHSAFEDEIISLSLGSAIVMDFKHPEGVTVQVMLPRRSLLVMTGESRYLWTHGITPRKFDTVQASEQFKGGIITSDIGDLTLSKRGMRTSFTFRKVRRMPCNCSYSSVCDRQRKATPPSLTESSKEALELEQKHVHQVYNEIASHFSSTRHSPWPRIVEFLKALPSGSIVADIGCGNGKYLGINKDLYMIGCDRSQNLVDICRERQFQALVCDALAVPVRSGSCDACISIAVIHHFATAERRVEALQELARLLRPGGQALIYVWAMEQEYKNQKSKYLRGKRISQGDKDELNSATSTEEFLVNQTPEGVNEDPALSVNSSSITKEEEYKSRKVPNSELPIHINRTCFHSQDVLVPWHLKRNPGKDKAIEPSGVAGCPDPSPVFHRYYHVFCDGELEASCQAVGDVSILQSYYDQGNWCVVLQKV
uniprot
proteins
ec_number
2.1.1.229
uniprot
proteins
function
FUNCTION: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys) (By similarity). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:20583019). Required for normal survival after DNA damage (By similarity). May inhibit apoptosis and promote cell survival and angiogenesis (By similarity). {ECO:0000250|UniProtKB:Q96BT7, ECO:0000269|PubMed:20123966, ECO:0000269|PubMed:20583019}.
uniprot
proteins
mass_dalton
74768
uniprot
proteins
mutagenesis
MUTAGEN 238; /note="H->A: Abolishes hydroxylation of 5-methylcarboxymethyl uridine."; /evidence="ECO:0000269|PubMed:20583019"; MUTAGEN 240; /note="D->A: Abolishes hydroxylation of 5-methylcarboxymethyl uridine."; /evidence="ECO:0000269|PubMed:20583019
uniprot
proteins
protein_family
AlkB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20123966
uniprot
proteins
pubmed
20583019
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
664
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96BT7}. Nucleus {ECO:0000250|UniProtKB:Q96BT7}. Note=Predominantly cytoplasmic. {ECO:0000250|UniProtKB:Q96BT7}.
uniprot
proteins