GPN3
entrez
51184
canonical
uniprot
Q9UHW5
canonical
ensembl
ENSG00000111231
resolver
ensp
ENSP00000228827
resolver
ensp
ENSP00000442770
resolver
ensp
ENSP00000443068
resolver
genesymbol
GPN3
resolver
genesymbol_syn
ATPBD1C
resolver
hgnc
HGNC:30186
resolver
uniprot
B2RC54
resolver
uniprot
D4YWV1
resolver
uniprot
F5H759
resolver
uniprot
Q53FS3
resolver
uniprot
Q6UVZ6
resolver
uniprot
Q7Z3D3
resolver
uniprot
Q8NEI2
resolver
uniprot
Q96HK9
resolver
uniprot_entry
GPN3_HUMAN
resolver
uniprot_sec
B2RC54
resolver
uniprot_sec
D4YWV1
resolver
uniprot_sec
F5H759
resolver
uniprot_sec
Q53FS3
resolver
uniprot_sec
Q6UVZ6
resolver
uniprot_sec
Q7Z3D3
resolver
uniprot_sec
Q8NEI2
resolver
uniprot_sec
Q96HK9
resolver
amino_acid_sequence
MPRYAQLVMGPAGSGKSTYCATMVQHCEALNRSVQVVNLDPAAEHFNYSVMADIRELIEVDDVMEDDSLRFGPNGGLVFCMEYFANNFDWLENCLGHVEDDYILFDCPGQIELYTHLPVMKQLVQQLEQWEFRVCGVFLVDSQFMVESFKFISGILAALSAMISLEIPQVNIMTKMDLLSKKAKKEIEKFLDPDMYSLLEDSTSDLRSKKFKKLTKAICGLIDDYSMVRFLPYDQSDEESMNIVLQHIDFAIQYGEDLEFKEPKEREDESSSMFDEYFQECQDE
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Small GTPase involved in the correct assembly of RNA polymerase II (RNAPII) complex, ensuring proper nuclear import of RNAPII. {ECO:0000269|PubMed:21768307}.
uniprot
proteins
mass_dalton
32761
uniprot
proteins
mutagenesis
MUTAGEN 210; /note="K->R: Slightly decreased ubiquitination. Further decreased ubiquitination; when associated with R-216."; /evidence="ECO:0000269|PubMed:29029378"; MUTAGEN 216; /note="K->R: Markedly decreased ubiquitination. Does not affect the movement between the cytoplasm and the nucleus. Slowly decreased protein abundance. Increased half-life. Further decreased ubiquitination; when associated with R-210."; /evidence="ECO:0000269|PubMed:29029378
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated and degraded by the proteasome in the nucleus (PubMed:29029378). Polyubiquitination is tightly controlled by GPN1 through interaction (PubMed:29029378). {ECO:0000269|PubMed:29029378}.
uniprot
proteins
protein_family
GPN-loop GTPase family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16533400
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20864038
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21768307
uniprot
proteins
pubmed
25241168
uniprot
proteins
pubmed
29029378
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25241168, ECO:0000269|PubMed:29029378}. Nucleus {ECO:0000269|PubMed:25241168, ECO:0000269|PubMed:29029378}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:25241168, ECO:0000269|PubMed:29029378}.
uniprot
proteins