Ms4a2
entrez
14126
canonical
uniprot
P20490
canonical
ensembl
ENSMUSG00000024680
resolver
ensp
ENSMUSP00000025583
resolver
ensp
ENSMUSP00000127373
resolver
ensp
ENSMUSP00000139841
resolver
ensp
ENSMUSP00000140628
resolver
ensp
ENSMUSP00000312526
resolver
enst
ENSMUST00000025583
resolver
enst
ENSMUST00000164792
resolver
enst
ENSMUST00000186978
resolver
enst
ENSMUST00000189641
resolver
genesymbol
Ms4a2
resolver
genesymbol_syn
Fce1b
resolver
genesymbol_syn
Fcer1b
resolver
genesymbol_syn
Ms4a1
resolver
uniprot
A0A087WPM9
resolver
uniprot
A0A0B4J1P0
resolver
uniprot
B2RTF7
resolver
uniprot
F8WIS2
resolver
uniprot
Q3UNT6
resolver
uniprot_entry
A0A087WPM9_MOUSE
resolver
uniprot_entry
A0A0B4J1P0_MOUSE
resolver
uniprot_entry
B2RTF7_MOUSE
resolver
uniprot_entry
F8WIS2_MOUSE
resolver
uniprot_entry
FCERB_MOUSE
resolver
uniprot_entry
Q3UNT6_MOUSE
resolver
amino_acid_sequence
MDTENRSRADLALPNPQESSSAPDIELLEASPAKAAPPKQTWRTFLKKELEFLGATQILVGLICLCFGTIVCSVLYVSDFDEEVLLLYKLGYPFWGAVLFVLSGFLSIISERKNTLYLVRGSLGANIVSSIAAGTGIAMLILNLTNNFAYMNNCKNVTEDDGCFVASFTTELVLMMLFLTILAFCSAVLFTIYRIGQELESKKVPDDRLYEELNVYSPIYSELEDKGETSSPVDS
uniprot
proteins
function
FUNCTION: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. {ECO:0000269|PubMed:19001085}.
uniprot
proteins
mass_dalton
25963
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by LYN. {ECO:0000269|PubMed:16272347}.
uniprot
proteins
protein_family
MS4A family
uniprot
proteins
pubmed
16272347
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19001085
uniprot
proteins
pubmed
2527850
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 52..71; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 90..109; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 123..142; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..191; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins