Otud1
entrez
71198
canonical
uniprot
Q9CUB6
canonical
ensembl
ENSMUSG00000043415
resolver
ensp
ENSMUSP00000100617
resolver
enst
ENSMUST00000052168
resolver
genesymbol
Otud1
resolver
uniprot
A2ATK4
resolver
uniprot_entry
OTUD1_MOUSE
resolver
uniprot_sec
A2ATK4
resolver
amino_acid_sequence
MQLYSSVCTHYPAGTPGPTAAAPPATAAAAFKVSLQSASPAAAAPEPDTGERPPAAATEPREAAAAAAMPAFSACFERSGSAAAPPGACSKPPLPPHFTSTAHIAVRALGAERLLLPPPSAPSPPRRGSSAWLLEELLRPDEPAAPNAVRDAPDRNFRLSEHRQALAASQHRAPAPAPVGPEPGAGPGSGPWGEERRAERSSRGWDRASGRSDASGSDALRRQDPEAEAHPVPAPARSSGEPAQNGEGEAVGTSRADPRDEKLALYLAEVERQDKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEGDVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWLSNGHYDAVFDHSYPNPEYDNWCKQTQIQKKRDEELAKSMAISLSKMYIEQNACS
uniprot
proteins
ec_number
3.4.19.12
uniprot
proteins
function
FUNCTION: Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin. Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598. OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation. {ECO:0000250|UniProtKB:Q5VV17}.
uniprot
proteins
mass_dalton
48823
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
454
uniprot
proteins