Slc9a2
entrez
226999
canonical
uniprot
Q3ZAS0
canonical
ensembl
ENSMUSG00000026062
resolver
ensp
ENSMUSP00000027231
resolver
enst
ENSMUST00000027231
resolver
genesymbol
Slc9a2
resolver
genesymbol_syn
Nhe2
resolver
uniprot_entry
SL9A2_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: In colonic crypts activated by low pHi, hyperosmolarity, and an increase in intracellular cAMP levels. {ECO:0000269|PubMed:14962844}.
uniprot
proteins
amino_acid_sequence
MGPRGTAHSVRAPLSWLLLLLLSLQVAVPAGALAETLLDAPRARGASSNPPSPASVVAPGTTPFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENFGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIQTVDVFAGIANFFVVGIGGVLIGILLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLIWRALGVFVLTQVINWFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPATVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIHCRFFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPSFASLNDCREEKIRKLTPGEMDEIREILSRNLYQIRQRTLSYNRHNLTADTSERQAKEILIRRRHSLRESLRKDNSSNRERRASTSTSRYLSLPKNTKLPEKLQKKKKVSNADGNSSDSDPDVGTTVLNLQPRTRRFLPDQFSKKASQAYKMEWKNEVDVGSVRVPPSVSPAPRSKDGGTQTPGLLRQPLLSKDQRFGRGREDSLTEDVPPKPPPRLVRRASEPGNRKGRLGNEKP
uniprot
proteins
function
FUNCTION: Plasma membrane Na(+)/H(+) antiporter (PubMed:14962844, PubMed:16690903). Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:14962844). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt (PubMed:14962844, PubMed:16690903). Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (PubMed:14962844, PubMed:34985202). {ECO:0000269|PubMed:14962844, ECO:0000269|PubMed:16690903, ECO:0000269|PubMed:34985202}.
uniprot
proteins
mass_dalton
91646
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
11099134
uniprot
proteins
pubmed
11705743
uniprot
proteins
pubmed
14962844
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16690903
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21900251
uniprot
proteins
pubmed
34985202
uniprot
proteins
pubmed
9502765
uniprot
proteins
sequence_length
814
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:21900251}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 108..128; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 210..230; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 279..299; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 309..329; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 393..413; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 431..451; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 460..480; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins