Srf
entrez
20807
canonical
uniprot
Q9JM73
canonical
ensembl
ENSMUSG00000015605
resolver
ensp
ENSMUSP00000015749
resolver
ensp
ENSMUSP00000300665
resolver
enst
ENSMUST00000015749
resolver
genesymbol
Srf
resolver
uniprot_entry
SRF_MOUSE
resolver
amino_acid_sequence
MLPSQAGAAAALGRGSALGGNLNRTPTGRPGGGGGTRGANGGRVPGNGAGLGQSRLEREAAAAAAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMELGVVVGGPEAAAAAAGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATGFEEPDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAIHVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMTSSVPTTVGGHMMYPSPHAVMYAPTSGLADGSLTVLNAFSQAPSTMQVSHSQVQEPGGVPQVFLTAPSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDATHSTKSE
uniprot
proteins
function
FUNCTION: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS) (PubMed:24732378). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:12732141, PubMed:19350017, PubMed:24732378). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics (PubMed:24732378). Required for cardiac differentiation and maturation (PubMed:15169892). {ECO:0000269|PubMed:12732141, ECO:0000269|PubMed:15169892, ECO:0000269|PubMed:19350017, ECO:0000269|PubMed:24732378}.
uniprot
proteins
mass_dalton
51247
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKDC. {ECO:0000250|UniProtKB:P11831}.
uniprot
proteins
pubmed
12732141
uniprot
proteins
pubmed
15169892
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15492011
uniprot
proteins
pubmed
16597624
uniprot
proteins
pubmed
16782067
uniprot
proteins
pubmed
16814806
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19350017
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24732378
uniprot
proteins
pubmed
33743134
uniprot
proteins
sequence_length
504
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:19350017}.
uniprot
proteins