Entpd8
entrez
613267
canonical
uniprot
Q5DRK1
canonical
ensembl
ENSRNOG00000009239
resolver
ensp
ENSRNOP00000012289
resolver
genesymbol
Entpd8
resolver
uniprot_entry
ENTP8_RAT
resolver
amino_acid_sequence
MRLSWKERVFMVLLGVAAASGLTMLILILVKATNVLLPADTKFGILFDAGSSHTSLFVYQWPANKEKDTGVVSQALACQVEGPGISSYTSDPTQAGESLKSCLQEALALIPQTQHPVTPAFLGATAGMRLLSQKNSSQAQDILAAVSQTLSRAPVDFWGARILAGQDEGAFGWITVNYVLGMLLKYSSGQWILPEDGTLVGALDLGGASTQISFVPQGPILDQSTQVTFRLYGANYSVYTHSYLCFGRDQILRRLLAELVQSSQVARVRHPCYHSGYQATLSLASLYDSPCVHTPDSLNYTQNLTVEGIGNPGNCVAALRGLFNFSSCKGQEDCAFNGVYQPPVHGQFYAFSNFYYTFQFLNLTSRQPLNIVNDTIWKFCQKPWRLVEDSYPGQERWLRDYCASGLYILVLLLEGYKFSEETWPNIQFQKQAGGTDIGWTLGFMLNLTGMIPAEALTQWRAQSYSIWIAGVVFAVLTLVAILGAAAVQLFWTQD
uniprot
proteins
ec_number
3.6.1.5
uniprot
proteins
function
FUNCTION: Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity (By similarity). Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs) (PubMed:17095758). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:17095758). This activity contributes to the regulation of extracellular levels of nucleotides (PubMed:17095758). Hydrolyzes ATP and ADP and prefers triphosphonucleosides and adenine over uracil as substrates (PubMed:17095758). Does not hydrolyzes AMP (PubMed:17095758). {ECO:0000250|UniProtKB:Q5MY95, ECO:0000269|PubMed:17095758}.
uniprot
proteins
mass_dalton
54330
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q5MY95}.
uniprot
proteins
protein_family
GDA1/CD39 NTPase family
uniprot
proteins
pubmed
17095758
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17095758}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in the canalicular membrane vesicle. {ECO:0000269|PubMed:17095758}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 466..486; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins