RAPGEF1
entrez
2889
canonical
uniprot
Q13905
canonical
ensembl
ENSG00000107263
resolver
ensp
ENSP00000361263
resolver
ensp
ENSP00000361264
resolver
ensp
ENSP00000361269
resolver
ensp
ENSP00000508246
resolver
ensp
ENSP00000584892
resolver
ensp
ENSP00000628150
resolver
enst
ENST00000683357
resolver
genesymbol
RAPGEF1
resolver
genesymbol_syn
GRF2
resolver
hgnc
HGNC:4568
resolver
uniprot
A0A1S5UYZ7
resolver
uniprot
A0A804HL87
resolver
uniprot
Q5JUE4
resolver
uniprot
Q68DL3
resolver
uniprot
Q8IV73
resolver
uniprot_entry
A0A1S5UYZ7_HUMAN
resolver
uniprot_entry
A0A804HL87_HUMAN
resolver
uniprot_entry
RPGF1_HUMAN
resolver
uniprot_sec
Q5JUE4
resolver
uniprot_sec
Q68DL3
resolver
uniprot_sec
Q8IV73
resolver
amino_acid_sequence
MDTDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRSAASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVEFVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKNKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLEPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKSPDALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT
uniprot
proteins
function
FUNCTION: Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}.
uniprot
proteins
mass_dalton
120548
uniprot
proteins
mutagenesis
MUTAGEN 504; /note="Y->F: Abolishes phosphorylation by HCK."; /evidence="ECO:0000269|PubMed:14551197
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-504 enhances activity as Rap guanine nucleotide exchange factor. {ECO:0000269|PubMed:14551197}.
uniprot
proteins
pubmed
12432078
uniprot
proteins
pubmed
14551197
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17724123
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21840392
uniprot
proteins
pubmed
23033978
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
7512734
uniprot
proteins
pubmed
7806500
uniprot
proteins
pubmed
8662907
uniprot
proteins
sequence_length
1077
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:17724123}.
uniprot
proteins