Slc26a7
entrez
208890
canonical
uniprot
Q8R2Z3
canonical
ensembl
ENSMUSG00000040569
resolver
ensp
ENSMUSP00000041789
resolver
enst
ENSMUST00000042221
resolver
genesymbol
Slc26a7
resolver
uniprot
A2AJZ4
resolver
uniprot
B1AWS0
resolver
uniprot_entry
S26A7_MOUSE
resolver
uniprot_sec
A2AJZ4
resolver
uniprot_sec
B1AWS0
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by pH. Activity inhibited by all inhibitors of several anion channels and transporters, including 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS), diphenylamine-2-carboxylic acid, glybenclamide and 5-Nitro-2-(3-phenylpropyl-amino)benzoic acid. {ECO:0000269|PubMed:12736153, ECO:0000269|PubMed:15591059, ECO:0000269|PubMed:24810589}.
uniprot
proteins
amino_acid_sequence
MTGAKRKKRSVLWGKMHTPHREDIKQWCKRRLPILEWAPQYNLKENLLPDTVSGIMLAVQQVAQGLSFAMLSSVHPVFGLYGSLFPAIIYAIFGMGRHVATGTFALTSLISANAVERLVPQSSRNLTTQSNSSVLGLSEFELQRIGVAAAVSFLGGVIQLVMFVLQLGSATFLLTEPVISAMTTGAATHVVTSQVKYLLGIKMPYISGPLGFFYIYAYVFENIKSVQLEALLFSLLSIIVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPNGIPPPRAPPMNILSAVLTEAFGVALVGYVASLALAQGSAKKFKYSVDDNQEFLAHGLSNVIPSFLFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWISTYIFTICFAANVGLLFGVICTIAIVLGRFPRAKTLSITDMKEMELKVKTEMHDETSQQIKIISINNPLVFLNAKKFSADLMKIILKESDSNQPLDDVSKCEQNTLLSSLSNGNCNEEASQPCSSEKCSLVLNCSGLTFFDYTGVSTLVELYLDCKSRSVDVFLANCTASLIKAMTYYGDLDTEKPIFFDSVPAAISIIQSNKNLSKASDHSEV
uniprot
proteins
function
FUNCTION: Acts as an anion channel mediating the transport of chloride, bromide, iodide, nitrate, sulfate, gluconate, thiocyanate and bicarbonate ions (PubMed:15591059, PubMed:24810589, PubMed:30333321, PubMed:32726161, PubMed:35788623). Its permeability towards bicarbonate is weak and increases when pH is above 7 (PubMed:15591059). Mediates oxalate transport (By similarity). Mediates thiocyanate transport in retinal pigment epithelium cells (PubMed:32726161). Mediates iodide transport in the thyroid gland, playing an important role in the synthesis of thyroid hormones and the maintenance of thyroid function (PubMed:30333321, PubMed:35788623). Although it is an anion channel, according to PubMed:12736153 and PubMed:19723628 it has been shown to exhibit chloride-bicarbonate exchanger activity. {ECO:0000250|UniProtKB:Q8TE54, ECO:0000269|PubMed:12736153, ECO:0000269|PubMed:15591059, ECO:0000269|PubMed:19723628, ECO:0000269|PubMed:24810589, ECO:0000269|PubMed:30333321, ECO:0000269|PubMed:32726161, ECO:0000269|PubMed:35788623}.
uniprot
proteins
mass_dalton
71829
uniprot
proteins
protein_family
SLC26A/SulP transporter (TC 2.A.53) family
uniprot
proteins
pubmed
12736153
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15591059
uniprot
proteins
pubmed
16263805
uniprot
proteins
pubmed
16524946
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19723628
uniprot
proteins
pubmed
24810589
uniprot
proteins
pubmed
30333321
uniprot
proteins
pubmed
32726161
uniprot
proteins
pubmed
35788623
uniprot
proteins
sequence_length
656
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12736153, ECO:0000269|PubMed:16263805, ECO:0000269|PubMed:16524946, ECO:0000269|PubMed:19723628, ECO:0000269|PubMed:24810589, ECO:0000269|PubMed:30333321, ECO:0000269|PubMed:32726161}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:16524946}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q8TE54}; Multi-pass membrane protein {ECO:0000255}. Lateral cell membrane {ECO:0000250|UniProtKB:Q8TE54}; Multi-pass membrane protein {ECO:0000255}. Note=Expressed on the basolateral membrane of acid-secreting gastric parietal cells, distal nephron segments and apical domains of proximal tubules and in the glomerulus. Expressed in the cytoplasm in recycling endosomes of kidney outer medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. {ECO:0000250|UniProtKB:Q8TE54, ECO:0000269|PubMed:12736153, ECO:0000269|PubMed:16263805, ECO:0000269|PubMed:16524946}.
uniprot
proteins
transmembrane_region
TRANSMEM 76..96; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 145..165; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 200..220; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 223..243; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 307..327; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 384..404; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 405..425; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 449..469; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins