Pnpla1
entrez
433091
canonical
uniprot
Q3V1D5
canonical
ensembl
ENSMUSG00000043286
resolver
ensp
ENSMUSP00000050123
resolver
enst
ENSMUST00000056866
resolver
genesymbol
Pnpla1
resolver
uniprot
B2KF06
resolver
uniprot_entry
B2KF06_MOUSE
resolver
uniprot_entry
PLPL1_MOUSE
resolver
amino_acid_sequence
MDEQVFKGDPDTPHSISFSGSGFLSYYQAGAVDALRDLAPRMLDTAHRFAGTSAGAVIAALVVCGIEMEKYLRVLNMGLAEVKKFFLGPLSPSCKMVQMMRQFLYDVLPEDSYKFATGKLHVSLTRVTDGENVVVSEYRSKEELIEALYCSCFVPVYCGFIPPTYRGERYIDGGFTSMQPCSFWTDSITISTFSSQQDICPRDCPTIFHDFRMFNFSFQFSLENITRMTHALFPPDLVILQEYYYRGYNDAVSYLRRLNAAYLDSPSKRVIFPRVEVYCQIEVALGHEPPPPSLQNLPALRRSPADSSQTHAQGSPKKDRKDSHSSAAPSVQTPESGCKESVESPVSLRVSISKQPSVSPLSPAQPVPVMRPTGPRDSCPINVQTPNPERGVKGALDSATERGMKDALASATDEQSTTTLPPVLLPAADSRGSKTGSSVPIGSPESPRLLLRSSQGATASRATLGLPPLSPSTPPAGPPVEDLGPERPTATGSPALSQLTGSAAPGTGKKAPHKPLLVEGPGEDSNTAKTMFKRKQKTNATRECFHRNAQSKKPASKLKSAPCPLNFPVLPKRVWVTYKPHPSRIQDYSYPEGVSGQNS
uniprot
proteins
ec_number
2.3.1.296
uniprot
proteins
function
FUNCTION: Omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation (PubMed:27751867, PubMed:28248300). Catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramide (PubMed:27751867, PubMed:28248300). Omega-O-acylceramides, are required for the biogenesis of lipid lamellae in the stratum corneum and the formation of the cornified lipid envelope which are essential for the epidermis barrier function (PubMed:27751867, PubMed:28248300). These lipids also play a role in keratinocyte differentiation (PubMed:28248300). May also act on omega-hydroxylated ultra-long chain fatty acids (omega-OH ULCFA) and acylglucosylceramides (GlcEOS) (PubMed:28248300). {ECO:0000269|PubMed:27751867, ECO:0000269|PubMed:28248300}.
uniprot
proteins
mass_dalton
65170
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
27751867
uniprot
proteins
pubmed
28248300
uniprot
proteins
sequence_length
599
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8N8W4}.
uniprot
proteins