A0A3G1DIU6
uniprot
A0A3G1DIU6
canonical
amino_acid_sequence
MGVKFFTLSTRFFPSVQRAVPLWTNS
uniprot
proteins
function
FUNCTION: Binds to and activates chemokine receptor ACKR3/CXCR7 which results in activation of proopiomelanocortin neurons in the arcuate nucleus of the hypothalamus, leading to suppression of food intake and increased energy expenditure (PubMed:37468558). Displays chaperone-like activity, inhibiting misfolding of IAPP and preventing IAPP amyloid formation (PubMed:28798389). Significantly reduces apoptosis and the generation of reactive oxygen species and improves mitochondrial metabolism in vitro (PubMed:27070352). {ECO:0000269|PubMed:27070352, ECO:0000269|PubMed:28798389, ECO:0000269|PubMed:37468558}.
uniprot
proteins
mass_dalton
3018
uniprot
proteins
pubmed
27070352
uniprot
proteins
pubmed
28798389
uniprot
proteins
pubmed
30310092
uniprot
proteins
pubmed
37468558
uniprot
proteins
pubmed
37591868
uniprot
proteins
pubmed
38167865
uniprot
proteins
pubmed
38940474
uniprot
proteins
pubmed
7219534
uniprot
proteins
sequence_length
26
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:37468558}. Mitochondrion inner membrane {ECO:0000269|PubMed:38167865}.
uniprot
proteins