Olig2
entrez
50913
canonical
uniprot
Q9EQW6
canonical
ensembl
ENSMUSG00000039830
resolver
ensp
ENSMUSP00000036797
resolver
enst
ENSMUST00000035608
resolver
genesymbol
Olig2
resolver
uniprot
Q542S0
resolver
uniprot
Q9JKN4
resolver
uniprot_entry
OLIG2_MOUSE
resolver
uniprot_entry
Q542S0_MOUSE
resolver
uniprot_sec
Q9JKN4
resolver
amino_acid_sequence
MDSDASLVSSRPSSPEPDDLFLPARSKGGSSSGFTGGTVSSSTPSDCPPELSSELRGAMGASGAHPGDKLGGGGFKSSSSSTSSSTSSAATSSTKKDKKQMTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPTATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSSASLPGSGLSSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGGSGGFQHWGGMPCPCSMCQVPPPHHHVSAMGAGTLPRLTSDAK
uniprot
proteins
function
FUNCTION: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain (PubMed:11955448, PubMed:12121626, PubMed:16908628). Works in coordination with ZNF488 to promote oligodendrocyte differentiation (PubMed:16908628). Orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis. In cooperation with OLIG2, activates oligodendrocyte precursor cells (OPCs) formation while repressing the generation of olfactory bulb interneuron intermediate progenitors (OBIN) through transcriptional regulation of GSX2. Mechanistically, binds and silences multiple conserved enhancer elements of GSX2. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube (PubMed:11955448, PubMed:12121626). Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (PubMed:11955448, PubMed:12121626). {ECO:0000269|PubMed:11955448, ECO:0000269|PubMed:12121626, ECO:0000269|PubMed:16908628}.
uniprot
proteins
mass_dalton
32407
uniprot
proteins
post_translational_modification
PTM: 'Lys-63'-linked polyubiquitinated by RNF220; leading to stabilization during oligodendroglial development and myelination. {ECO:0000250|UniProtKB:Q8TAK6}.
uniprot
proteins
pubmed
10719888
uniprot
proteins
pubmed
10719889
uniprot
proteins
pubmed
11091082
uniprot
proteins
pubmed
11955448
uniprot
proteins
pubmed
11960707
uniprot
proteins
pubmed
12121626
uniprot
proteins
pubmed
14573534
uniprot
proteins
pubmed
14602683
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16908628
uniprot
proteins
pubmed
41193423
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
uniprot
proteins