Il12rb2
entrez
16162
canonical
uniprot
P97378
canonical
ensembl
ENSMUSG00000018341
resolver
ensp
ENSMUSP00000010605
resolver
ensp
ENSMUSP00000113267
resolver
enst
ENSMUST00000018485
resolver
enst
ENSMUST00000117441
resolver
genesymbol
Il12rb2
resolver
uniprot
B9EHD9
resolver
uniprot
D3Z6H5
resolver
uniprot_entry
D3Z6H5_MOUSE
resolver
uniprot_entry
I12R2_MOUSE
resolver
uniprot_sec
B9EHD9
resolver
amino_acid_sequence
MAQTVRECSLALLFLFMWLLIKANIDVCKLGTVTVQPAPVIPLGSAANISCSLNPKQGCSHYPSSNELILLKFVNDVLVENLHGKKVHDHTGHSSTFQVTNLSLGMTLFVCKLNCSNSQKKPPVPVCGVEISVGVAPEPPQNISCVQEGENGTVACSWNSGKVTYLKTNYTLQLSGPNNLTCQKQCFSDNRQNCNRLDLGINLSPDLAESRFIVRVTAINDLGNSSSLPHTFTFLDIVIPLPPWDIRINFLNASGSRGTLQWEDEGQVVLNQLRYQPLNSTSWNMVNATNAKGKYDLRDLRPFTEYEFQISSKLHLSGGSWSNWSESLRTRTPEEEPVGILDIWYMKQDIDYDRQQISLFWKSLNPSEARGKILHYQVTLQEVTKKTTLQNTTRHTSWTRVIPRTGAWTASVSAANSKGASAPTHINIVDLCGTGLLAPHQVSAKSENMDNILVTWQPPKKADSAVREYIVEWRALQPGSITKFPPHWLRIPPDNMSALISENIKPYICYEIRVHALSESQGGCSSIRGDSKHKAPVSGPHITAITEKKERLFISWTHIPFPEQRGCILHYRIYWKERDSTAQPELCEIQYRRSQNSHPISSLQPRVTYVLWMTAVTAAGESPQGNEREFCPQGKANWKAFVISSICIAIITVGTFSIRYFRQKAFTLLSTLKPQWYSRTIPDPANSTWVKKYPILEEKIQLPTDNLLMAWPTPEEPEPLIIHEVLYHMIPVVRQPYYFKRGQGFQGYSTSKQDAMYIANPQATGTLTAETRQLVNLYKVLESRDPDSKLANLTSPLTVTPVNYLPSHEGYLPSNIEDLSPHEADPTDSFDLEHQHISLSIFASSSLRPLIFGGERLTLDRLKMGYDSLMSNEA
uniprot
proteins
function
FUNCTION: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. Can also activate STAT3. {ECO:0000269|PubMed:12370372}.
uniprot
proteins
mass_dalton
98197
uniprot
proteins
mutagenesis
MUTAGEN 677; /note="Y->F: No loss of IL12-induced STAT4 activation nor T-cell proliferation. No effect on IFN-gamma production."; /evidence="ECO:0000269|PubMed:12370372"; MUTAGEN 693; /note="Y->F: No loss of IL12-induced STAT4 activation nor T-cell proliferation. No effect on IFN-gamma production."; /evidence="ECO:0000269|PubMed:12370372"; MUTAGEN 727; /note="Y->F: No loss of IL12-induced STAT4 activation nor T-cell proliferation. No effect on IFN-gamma production."; /evidence="ECO:0000269|PubMed:12370372"; MUTAGEN 737; /note="Y->F: No loss of IL12-induced STAT4 activation nor T-cell proliferation. No effect on IFN-gamma production."; /evidence="ECO:0000269|PubMed:12370372"; MUTAGEN 748; /note="Y->F: No loss of IL12-induced STAT4 activation nor T-cell proliferation. No effect on IFN-gamma production."; /evidence="ECO:0000269|PubMed:12370372"; MUTAGEN 757; /note="Y->F: No loss of IL12-induced STAT4 activation nor T-cell proliferation. No effect on IFN-gamma production."; /evidence="ECO:0000269|PubMed:12370372"; MUTAGEN 778; /note="Y->F: No loss of IL12-induced STAT4 activation nor T-cell proliferation. No effect on IFN-gamma production."; /evidence="ECO:0000269|PubMed:12370372"; MUTAGEN 804; /note="Y->F: No loss of IL12-induced STAT4 activation nor T-cell proliferation. No effect on IFN-gamma production."; /evidence="ECO:0000269|PubMed:12370372"; MUTAGEN 811; /note="Y->F: No loss of IL12-induced STAT4 activation. Greatly reduced IL12-induced T-cell proliferation and IFN-gamma production."; /evidence="ECO:0000269|PubMed:12370372"; MUTAGEN 866; /note="Y->F: No loss of IL12-induced STAT4 activation nor T-cell proliferation. No effect on IFN-gamma production."; /evidence="ECO:0000269|PubMed:12370372
uniprot
proteins
post_translational_modification
PTM: On IL12 stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation of any one of Tyr-757, Tyr-804 or Tyr-811 can activate STAT4, IFN-gamma production, and T-cell proliferation. Tyr-811 is the dominant site of cell proliferation.
uniprot
proteins
protein_family
Type 2 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
11489994
uniprot
proteins
pubmed
12370372
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8943050
uniprot
proteins
pubmed
9120387
uniprot
proteins
sequence_length
874
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 638..658; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins