Reg3b
entrez
18489
canonical
uniprot
P35230
canonical
ensembl
ENSMUSG00000071356
resolver
ensp
ENSMUSP00000094667
resolver
enst
ENSMUST00000096904
resolver
genesymbol
Reg3b
resolver
genesymbol_syn
Pap
resolver
genesymbol_syn
Pap1
resolver
uniprot_entry
REG3B_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: [Regenerating islet-derived protein 3-beta 15 kDa form]: Lipopolysaccharide inhibits pore-forming activity, explaining why is bactericidal for Gram-positive but not Gram-negative bacteria. {ECO:0000250|UniProtKB:Q06141}.
uniprot
proteins
amino_acid_sequence
MLPPTACSVMSWMLLSCLMLLSQVQGEDSLKNIPSARISCPKGSQAYGSYCYALFQIPQTWFDAELACQKRPGGHLVSVLNSAEASFLSSMVKRTGNSYQYTWIGLHDPTLGAEPNGGGWEWSNNDVMNYFNWERNPSTALDRAFCGSLSRASGFLKWRDMTCEVKLPYVCKFTG
uniprot
proteins
disease_involvement
DISEASE: Note=Overexpressed during the acute phase of pancreatitis.
uniprot
proteins
function
FUNCTION: Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues. {ECO:0000269|PubMed:21694778, ECO:0000269|PubMed:22252863}.; FUNCTION: Acts as a hormone in response to different stimuli. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways (PubMed:34099862). In pancreas, is able stimulate cell proliferation (PubMed:34099862). {ECO:0000269|PubMed:34099862}.
uniprot
proteins
mass_dalton
19476
uniprot
proteins
post_translational_modification
PTM: Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. {ECO:0000269|PubMed:21694778}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21694778
uniprot
proteins
pubmed
22252863
uniprot
proteins
pubmed
34099862
uniprot
proteins
pubmed
7679928
uniprot
proteins
pubmed
9055810
uniprot
proteins
sequence_length
175
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:34099862}. Note=Found in the apical region of pancreatic acinar cells. {ECO:0000305|PubMed:34099862}.
uniprot
proteins