Prps2
entrez
24689
canonical
uniprot
P09330
canonical
ensembl
ENSRNOG00000004160
resolver
ensp
ENSRNOP00000005615
resolver
enst
ENSRNOT00000005615
resolver
genesymbol
Prps2
resolver
uniprot
A0A8L2Q1L2
resolver
uniprot
Q63462
resolver
uniprot_entry
A0A8L2Q1L2_RAT
resolver
uniprot_entry
PRPS2_RAT
resolver
uniprot_sec
Q63462
resolver
activity_regulation
ACTIVITY REGULATION: Activated by magnesium. Activated by inorganic phosphate (Pi) that binds D-ribose 5-phosphate binding site. Inhibited by GDP. Feedback inhibition by purine nucleotides is less sensitive than inhibition by 2,3-diphosphoglycerate. ADP can regulate enzyme activity through competitive inhibition and allosteric inhibition by affecting the conformation of regulatory flexible (RF) loop. The ADP of allosteric site can interact with RF loop, leading to the regulation of ATP conformation in active site. Competitive inhibition of ADP by binding to the ATP active site in the hexamer where also binds magnesium. Thermal inactivation at 55 degrees Celsius. {ECO:0000250|UniProtKB:P11908}.
uniprot
proteins
amino_acid_sequence
MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENITEWRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL
uniprot
proteins
ec_number
2.7.6.1
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of the pyrophosphoryl group from ATP to the 1-hydroxyl of ribose-5-phosphate to form 5-phospho-ribosyl-1-pyrophosphate (PRPP), a key intermediate in the biosynthesis of several metabolites including nucleotides, dinucleotides and some amino acids. Involved in the production of newly synthesized ATP/GTP through the purine biosynthesis pathway. {ECO:0000250|UniProtKB:P11908}.
uniprot
proteins
mass_dalton
34813
uniprot
proteins
pathway_participation
PATHWAY: Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. {ECO:0000250|UniProtKB:P11908}.
uniprot
proteins
protein_family
Ribose-phosphate pyrophosphokinase family
uniprot
proteins
pubmed
2555778
uniprot
proteins
pubmed
2822704
uniprot
proteins
sequence_length
318
uniprot
proteins