Klhl42
entrez
232539
canonical
uniprot
Q8BFQ9
canonical
ensembl
ENSMUSG00000040102
resolver
ensp
ENSMUSP00000042558
resolver
ensp
ENSMUSP00000255620
resolver
enst
ENSMUST00000036003
resolver
genesymbol
Klhl42
resolver
genesymbol_syn
Kiaa1340
resolver
genesymbol_syn
Klhdc5
resolver
uniprot
B2KFS7
resolver
uniprot
Q6ZPT4
resolver
uniprot_entry
B2KFS7_MOUSE
resolver
uniprot_entry
KLH42_MOUSE
resolver
uniprot_sec
Q6ZPT4
resolver
amino_acid_sequence
MSAEEMVQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVGPEVQQLRGLSAPGLRLVLDFINAGGAREGWGLSEDELAEASVLSEMVEAASFLQVTALLRLLLSHVRLGNCLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQFPLLLSPPQAPGDCSLKQRLREARMRGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEETTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPITNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSADLWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVTLSTSLEHRVFLKYNIFADSWEAFRRFPAFGHNLLISSLYLPNKAET
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
55599
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Predominantly in mitotic cells. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase cells is localized between the two sets of separated chromosomes as well as at the spindle poles (By similarity). During telophase is localized arround the nuclei of the two daughter cells. Not detected at the midbody region during cytokinesis. {ECO:0000250}.
uniprot
proteins