Suv39h1
entrez
20937
canonical
uniprot
O54864
canonical
ensembl
ENSMUSG00000039231
resolver
ensp
ENSMUSP00000111300
resolver
ensp
ENSMUSP00000111301
resolver
ensp
ENSMUSP00000309273
resolver
enst
ENSMUST00000115637
resolver
genesymbol
Suv39h1
resolver
genesymbol_syn
Suv39h
resolver
uniprot
A2AC19
resolver
uniprot
Q3TEW2
resolver
uniprot
Q3UT51
resolver
uniprot
Q8C2L3
resolver
uniprot
Q9JLC7
resolver
uniprot
Q9JLP8
resolver
uniprot_entry
A2AC19_MOUSE
resolver
uniprot_entry
SUV91_MOUSE
resolver
uniprot_sec
Q3TEW2
resolver
uniprot_sec
Q3UT51
resolver
uniprot_sec
Q8C2L3
resolver
uniprot_sec
Q9JLC7
resolver
uniprot_sec
Q9JLP8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by S-adenosyl-L-homocysteine. Negatively regulated by CCAR2. {ECO:0000250|UniProtKB:O43463}.
uniprot
proteins
amino_acid_sequence
MAENLKGCSVCCKSSWNQLQDLCRLAKLSCPALGVSKKNLYDFEVEYLCDYKKIREQEYYLVKWRGYPDSENTWEPRQNLKCIRVLKQFHKDLERELVRRHRRSKPPRHLDPNLANYLVQKAKQRRALQRWEQELNAKRSHLGRITVENEVDLDGPPRSFVYINEYRVGEGITLNQVAVGCECQDCLLAPTGGCCPGASLHKFAYNDQGQVRLKAGQPIYECNSRCCCGYDCPNRVVQKGIRYDLCIFRTNDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTTACRKYLF
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate (PubMed:10949293, PubMed:11701123, PubMed:14690609, PubMed:14690610, PubMed:18004385, PubMed:22939622, PubMed:30111536). Also weakly methylates histone H1 (in vitro) (By similarity). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones (PubMed:10949293). Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions (PubMed:14702045). H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats (PubMed:12867029). SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length (By similarity). Involved in the maintenance of H3K9me3 mark following DNA replication, when histone marks are diluted: HP1 recognizes the preexisting H3K9me3 mark and serves as a platform to recruit SUV39H1 to modify the adjacent newly incorporated histones (PubMed:10949293). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (By similarity). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (By similarity). Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (PubMed:24413057). {ECO:0000250|UniProtKB:O43463, ECO:0000269|PubMed:10949293, ECO:0000269|PubMed:11701123, ECO:0000269|PubMed:12867029, ECO:0000269|PubMed:14690609, ECO:0000269|PubMed:14690610, ECO:0000269|PubMed:14702045, ECO:0000269|PubMed:18004385, ECO:0000269|PubMed:22939622, ECO:0000269|PubMed:24413057, ECO:0000269|PubMed:30111536}.
uniprot
proteins
mass_dalton
47754
uniprot
proteins
mutagenesis
MUTAGEN 324..326; /note="HSC->LAA: No effect on rates of development into blastocysts."; /evidence="ECO:0000269|PubMed:30111536
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues, and to a lesser degree, on threonine residues (By similarity). Phosphorylated at Ser-391 by CDK2 during S-M phases, impairing localization to heterochromatin (PubMed:24728993). {ECO:0000250|UniProtKB:O43463, ECO:0000269|PubMed:24728993}.; PTM: Acetylated at Lys-266, leading to inhibition of enzyme activity. SIRT1-mediated deacetylation relieves this inhibition (By similarity). {ECO:0000250|UniProtKB:O43463}.; PTM: Ubiquitinated by the DCX(DCAF13) E3 ubiquitin ligase complex, leading to its degradation (PubMed:30111536). Ubiquitinated at Lys-138 by the ECS(ASB7) complex, leading to its degradation (By similarity). {ECO:0000250|UniProtKB:O43463, ECO:0000269|PubMed:30111536}.
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
protein_family
Suvar3-9 subfamily
uniprot
proteins
pubmed
10202156
uniprot
proteins
pubmed
10754099
uniprot
proteins
pubmed
10949293
uniprot
proteins
pubmed
11094092
uniprot
proteins
pubmed
11701123
uniprot
proteins
pubmed
11788710
uniprot
proteins
pubmed
12867029
uniprot
proteins
pubmed
14690609
uniprot
proteins
pubmed
14690610
uniprot
proteins
pubmed
14702045
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18004385
uniprot
proteins
pubmed
18619962
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22939622
uniprot
proteins
pubmed
23695662
uniprot
proteins
pubmed
24413057
uniprot
proteins
pubmed
24728993
uniprot
proteins
pubmed
30111536
uniprot
proteins
pubmed
38961301
uniprot
proteins
sequence_length
412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10202156, ECO:0000269|PubMed:18004385}. Chromosome {ECO:0000250|UniProtKB:O43463}. Nucleus lamina {ECO:0000250|UniProtKB:O43463}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:O43463}. Chromosome, centromere {ECO:0000269|PubMed:10202156, ECO:0000269|PubMed:18004385}. Note=Associates with centromeric constitutive heterochromatin (PubMed:10202156, PubMed:18004385). Recruited to pericentromeric heterochromatin via its chromo domain, which specifically recognizes and binds histone H3 monoubiquitinated at 'Lys-14' (H3K14ub) (By similarity). {ECO:0000250|UniProtKB:O43463, ECO:0000269|PubMed:10202156, ECO:0000269|PubMed:18004385}.
uniprot
proteins