PTGES
entrez
9536
canonical
uniprot
O14684
canonical
ensembl
ENSG00000148344
resolver
ensp
ENSP00000342385
resolver
enst
ENST00000340607
resolver
genesymbol
PTGES
resolver
genesymbol_syn
MGST1L1
resolver
genesymbol_syn
MPGES1
resolver
genesymbol_syn
PGES
resolver
genesymbol_syn
PIG12
resolver
hgnc
HGNC:9599
resolver
uniprot
O14900
resolver
uniprot
Q5SZC0
resolver
uniprot_entry
PTGES_HUMAN
resolver
uniprot_sec
O14900
resolver
uniprot_sec
Q5SZC0
resolver
activity_regulation
ACTIVITY REGULATION: Induced by interleukin IL1B. {ECO:0000269|PubMed:10760517}.
uniprot
proteins
amino_acid_sequence
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
ec_number
2.5.1.18
uniprot
proteins
ec_number
5.3.99.3
uniprot
proteins
function
FUNCTION: Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:10377395, PubMed:10869354, PubMed:12244105, PubMed:12460774, PubMed:12672824, PubMed:17519235, PubMed:18682561). Similarly, catalyzes the conversion of PGH3 (derived from eicosapentaenoate (EPA, C20:5n-3)) to PGE3, though PGH2 remains the preferred substrate (PubMed:17519235). Plays a key role in inflammation response, fever and pain (By similarity). Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824). {ECO:0000250|UniProtKB:Q9JM51, ECO:0000269|PubMed:10377395, ECO:0000269|PubMed:10869354, ECO:0000269|PubMed:12244105, ECO:0000269|PubMed:12460774, ECO:0000269|PubMed:12672824, ECO:0000269|PubMed:17519235, ECO:0000269|PubMed:18682561}.
uniprot
proteins
mass_dalton
17102
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="Q->E: Keeps about 40-50% of prostaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:16439136"; MUTAGEN 49; /note="D->A: Loss of prostaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:27684486"; MUTAGEN 49; /note="D->N: Loss of prostaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:26755582"; MUTAGEN 66; /note="E->A: Reduces protaglandin-E synthase activity by 50%."; /evidence="ECO:0000269|PubMed:18682561"; MUTAGEN 67; /note="R->A: Loss of prostaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:18682561"; MUTAGEN 70; /note="R->A: Slightly reduced protaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:18682561"; MUTAGEN 70; /note="R->S: No effect on protaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:10869354"; MUTAGEN 72; /note="H->A: Reduces protaglandin-E synthase activity by 70%."; /evidence="ECO:0000269|PubMed:18682561"; MUTAGEN 73; /note="R->A: Retains partial of protaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:27684486"; MUTAGEN 73; /note="R->L: Loss of protaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:27684486"; MUTAGEN 110; /note="R->A,S: Loss of protaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:10869354, ECO:0000269|PubMed:18682561"; MUTAGEN 110; /note="R->T: Retains 17.8% of protaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:16439136"; MUTAGEN 114; /note="T->V: Retains 21.3% activity of protaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:16439136"; MUTAGEN 117; /note="Y->A: Loss of protaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:18682561"; MUTAGEN 117; /note="Y->F: No effect on protaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:10869354, ECO:0000269|PubMed:18682561"; MUTAGEN 126; /note="R->A,L: Loss of prostaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:27684486"; MUTAGEN 126; /note="R->K: Loss of prostaglandin-E synthase activity. Transforms prostaglandin-E synthase activity to prostaglandin-F(2alpha)synthase activity."; /evidence="ECO:0000269|PubMed:26755582"; MUTAGEN 126; /note="R->Q: Loss of prostaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:26755582"; MUTAGEN 127; /note="S->A: No effect on protaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:26755582, ECO:0000269|PubMed:27684486"; MUTAGEN 130; /note="Y->I: Loss of protaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:16439136"; MUTAGEN 134; /note="Q->E: Keeps about 40-50% of prostaglandin-E synthase activity."; /evidence="ECO:0000269|PubMed:16439136
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; prostaglandin biosynthesis. {ECO:0000269|PubMed:10869354}.
uniprot
proteins
protein_family
MAPEG family
uniprot
proteins
pubmed
10377395
uniprot
proteins
pubmed
10760517
uniprot
proteins
pubmed
10869354
uniprot
proteins
pubmed
12244105
uniprot
proteins
pubmed
12460774
uniprot
proteins
pubmed
12672824
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16439136
uniprot
proteins
pubmed
17519235
uniprot
proteins
pubmed
18682561
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23431194
uniprot
proteins
pubmed
26755582
uniprot
proteins
pubmed
27684486
uniprot
proteins
pubmed
9305847
uniprot
proteins
sequence_length
152
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10377395, ECO:0000269|PubMed:16439136, ECO:0000269|PubMed:18682561, ECO:0000269|PubMed:27684486}; Multi-pass membrane protein {ECO:0000303|PubMed:18682561}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10869354}. Note=Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment. {ECO:0000269|PubMed:10869354}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..41; /note="Helical"; /evidence="ECO:0000305|PubMed:23431194"; TRANSMEM 61..90; /note="Helical"; /evidence="ECO:0000305|PubMed:23431194"; TRANSMEM 96..119; /note="Helical"; /evidence="ECO:0000305|PubMed:23431194"; TRANSMEM 124..152; /note="Helical"; /evidence="ECO:0000305|PubMed:23431194
uniprot
proteins