Pik3r1
entrez
25513
canonical
uniprot
Q63787
canonical
ensembl
ENSRNOG00000018903
resolver
ensp
ENSRNOP00000067155
resolver
ensp
ENSRNOP00000104471
resolver
enst
ENSRNOT00000075057
resolver
enst
ENSRNOT00000159310
resolver
genesymbol
Pik3r1
resolver
uniprot
A0ABK0L4M6
resolver
uniprot
M0RC47
resolver
uniprot
O55085
resolver
uniprot
P70544
resolver
uniprot
Q63790
resolver
uniprot_entry
A0ABK0L4M6_RAT
resolver
uniprot_entry
M0RC47_RAT
resolver
uniprot_entry
P85A_RAT
resolver
uniprot_sec
O55085
resolver
uniprot_sec
P70544
resolver
uniprot_sec
Q63790
resolver
amino_acid_sequence
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEDIGWLNGYNETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSSKTEADTEQPVLTLPDLAEQFAPPDVAPPLLIKLLEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDPPSVDLDVFDEHVLADAFKRYLADLPNPVIPVAVYNEMMSLAQEVPSSEDYIQLLKKLIRSPNIPHQYWLTLQYLLKHFFKLSQASSKNLLNARALSEIFSHVLFRFPAASSDNTEHLIKAVELLISAEWSERQPAPALPPKPPKPTSIANNSMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNDTIKIFEEQCHPQERYSKDYIEKFKREGNEKEIQRIMHNHDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVDDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
uniprot
proteins
function
FUNCTION: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). {ECO:0000250|UniProtKB:P26450, ECO:0000250|UniProtKB:P27986}.
uniprot
proteins
mass_dalton
83531
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation. {ECO:0000250}.; PTM: Phosphorylated. Tyrosine phosphorylated in response to signaling by FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated by CSF1R. Phosphorylated on tyrosine residues by TEK/TIE2. Dephosphorylated by PTPRJ. Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF. The relevance of phosphorylation by PIK3CA is however unclear. Phosphorylated in response to KIT and KITLG/SCF. Phosphorylated by FGR and ERBB4 (By similarity). {ECO:0000250}.; PTM: In adipose tissue, polyubiquitinated by the BCR(KBTBD2) E3 ubiquitin ligase complex; recognized by KBTBD2 through the SH2 domains, undergoes 'Lys-48'-linked polyubiquitination leading to its degradation. {ECO:0000250|UniProtKB:P26450}.
uniprot
proteins
protein_family
PI3K p85 subunit family
uniprot
proteins
pubmed
11353842
uniprot
proteins
pubmed
7518429
uniprot
proteins
pubmed
8621382
uniprot
proteins
pubmed
8628286
uniprot
proteins
pubmed
8824286
uniprot
proteins
pubmed
8921377
uniprot
proteins
pubmed
9065454
uniprot
proteins
pubmed
9677338
uniprot
proteins
sequence_length
724
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P27986}.
uniprot
proteins