PINX1
entrez
54984
canonical
uniprot
Q96BK5
canonical
ensembl
ENSG00000254093
resolver
ensembl
ENSG00000284764
resolver
ensp
ENSP00000318966
resolver
ensp
ENSP00000428853
resolver
genesymbol
PINX1
resolver
genesymbol_syn
LPTL
resolver
genesymbol_syn
LPTS
resolver
hgnc
HGNC:30046
resolver
uniprot
B2R9B1
resolver
uniprot
Q548A5
resolver
uniprot
Q6QWG9
resolver
uniprot
Q7Z7J8
resolver
uniprot
Q96QD7
resolver
uniprot
Q9HBU7
resolver
uniprot
Q9NWW2
resolver
uniprot_entry
PINX1_HUMAN
resolver
uniprot_sec
B2R9B1
resolver
uniprot_sec
Q548A5
resolver
uniprot_sec
Q6QWG9
resolver
uniprot_sec
Q7Z7J8
resolver
uniprot_sec
Q96QD7
resolver
uniprot_sec
Q9HBU7
resolver
uniprot_sec
Q9NWW2
resolver
amino_acid_sequence
MSMLAERRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQEQGATDHIKVQVKNNHLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDLDCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKPKKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK
uniprot
proteins
function
FUNCTION: Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. {ECO:0000269|PubMed:15381700, ECO:0000269|PubMed:17198684, ECO:0000269|PubMed:19117989, ECO:0000269|PubMed:19265708, ECO:0000269|PubMed:19393617, ECO:0000269|PubMed:19553660}.
uniprot
proteins
mass_dalton
37035
uniprot
proteins
mutagenesis
MUTAGEN 50; /note="Q->A: Abolishes cleavage by enterovirus 71."; /evidence="ECO:0000269|PubMed:27847364"; MUTAGEN 291; /note="L->A: Abolishes interaction with TERF1."; /evidence="ECO:0000269|PubMed:18202258"; MUTAGEN 293; /note="P->A: Does not affect interaction with TERF1."; /evidence="ECO:0000269|PubMed:18202258
uniprot
proteins
post_translational_modification
PTM: Cleaved by enterovirus protease 3C to promote apoptosis. {ECO:0000269|PubMed:27847364}.
uniprot
proteins
protein_family
PINX1 family
uniprot
proteins
pubmed
11003615
uniprot
proteins
pubmed
11701125
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15044100
uniprot
proteins
pubmed
15381700
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17198684
uniprot
proteins
pubmed
18202258
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19117989
uniprot
proteins
pubmed
19265708
uniprot
proteins
pubmed
19393617
uniprot
proteins
pubmed
19553660
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27847364
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27847364}. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Note=Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
uniprot
proteins