CLECL1
entrez
160365
canonical
uniprot
Q8IZS7
canonical
ensembl
ENSG00000293488
resolver
ensp
ENSP00000643117
resolver
ensp
ENSP00000643120
resolver
ensp
ENSP00000643121
resolver
ensp
ENSP00000643125
resolver
genesymbol
CLECL1
resolver
genesymbol_syn
CLECL1P
resolver
genesymbol_syn
DCAL1
resolver
hgnc
HGNC:24462
resolver
uniprot_entry
CLCL1_HUMAN
resolver
amino_acid_sequence
MVSNFFHVIQVFEKSATLISKTEHIGFVIYSWRKSTTHLGSRRKFAISIYLSEVSLQKYDCPFSGTSFVVFSLFLICAMAGDVVYADIKTVRTSPLELAFPLQRSVSFNFSTVHKSCPAKDWKVHKGKCYWIAETKKSWNKSQNDCAINNSYLMVIQDITAMVRFNI
uniprot
proteins
function
FUNCTION: Functions in mediating immune cell-cell interactions (PubMed:12421943, PubMed:19027044). Acts as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response. Expressed in immature dendritic cells, activates downstream signaling, incuding MAPK signaling pathway leading to an induction of the major histocompatibility complex (MHC) class II expression (PubMed:19027044). {ECO:0000269|PubMed:12421943, ECO:0000269|PubMed:19027044}.
uniprot
proteins
mass_dalton
19115
uniprot
proteins
pubmed
12421943
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19027044
uniprot
proteins
sequence_length
167
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12421943}; Single-pass type II membrane protein {ECO:0000269|PubMed:12421943}.
uniprot
proteins
transmembrane_region
TRANSMEM 68..88; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins