Fem1aa
entrez
14154
canonical
uniprot
Q9Z2G1
canonical
ensembl
ENSMUSG00000043683
resolver
ensp
ENSMUSP00000057996
resolver
enst
ENSMUST00000060253
resolver
genesymbol
Fem1aa
resolver
genesymbol_syn
Eprap
resolver
genesymbol_syn
Fem1a
resolver
uniprot
Q3U2C2
resolver
uniprot
Q8C4V3
resolver
uniprot
Q8C6D9
resolver
uniprot
Q8CBW9
resolver
uniprot
Q9DBC6
resolver
uniprot_entry
FM1AA_MOUSE
resolver
uniprot_sec
Q3U2C2
resolver
uniprot_sec
Q8C4V3
resolver
uniprot_sec
Q8C6D9
resolver
uniprot_sec
Q8CBW9
resolver
uniprot_sec
Q9DBC6
resolver
amino_acid_sequence
MDLHTAVYNAAHDGKLPLLQKLLAGRGREELEELLGEVAGGGTPLLIAARRGHLDVVEYLVDHCGASVEASGSVHFDGETIEGAPPLWAASAAGHLAVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLDVVRYLVGEHKADLEVANRHGHTCLMISCYKGHREIARYLLERGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCHARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGHEQLSGTELPGEGSSQVAGNHCSTPEEAEPYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGGYLPKPEPQQLVLAYDYSREVTTPQELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQNNLEPLSPMTASSFLSFAELFSYVLQDRSAKGNLGMQLGFADLMGVLSKGVREVERALQLPKEPGDSAQFTKAIAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKETTNVGRYRVGVFPSLQVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMDALIEAGAHMDATNAFKKTAYELLDSKLLAKSTVQPFNYVTLQCLAARALDRNKVPYKGFIPEELEAFIQLH
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (By similarity). Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (PubMed:18270204, PubMed:26439841). Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (PubMed:27315781). {ECO:0000250|UniProtKB:Q9BSK4, ECO:0000269|PubMed:18270204, ECO:0000269|PubMed:26439841, ECO:0000269|PubMed:27315781}.
uniprot
proteins
mass_dalton
72089
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="S->A: Decreased ability to promote PGE2-EP4-mediated inhibition of inflammation; when associated with A-608."; /evidence="ECO:0000269|PubMed:27799315"; MUTAGEN 608; /note="S->A: Decreased ability to promote PGE2-EP4-mediated inhibition of inflammation; when associated with A-108."; /evidence="ECO:0000269|PubMed:27799315
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9BSK4}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; highly phosphorylated in myoblasts and myotubes (PubMed:19406122). Phosphorylation at Ser-108 and Ser-608 promote PGE2-EP4-mediated inhibition of inflammation (PubMed:27799315). Dephosphorylated by protein phosphatase 2A (PP2A) (PubMed:27799315). {ECO:0000269|PubMed:19406122, ECO:0000269|PubMed:27799315}.
uniprot
proteins
protein_family
Fem-1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18270204
uniprot
proteins
pubmed
19406122
uniprot
proteins
pubmed
26439841
uniprot
proteins
pubmed
27315781
uniprot
proteins
pubmed
27799315
uniprot
proteins
pubmed
28336432
uniprot
proteins
pubmed
28624505
uniprot
proteins
pubmed
9828124
uniprot
proteins
sequence_length
654
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:19406122}. Cytoplasm {ECO:0000250|UniProtKB:Q9BSK4}.
uniprot
proteins