TMEM74
entrez
157753
canonical
uniprot
Q96NL1
canonical
ensembl
ENSG00000164841
resolver
ensp
ENSP00000297459
resolver
ensp
ENSP00000569559
resolver
ensp
ENSP00000569560
resolver
ensp
ENSP00000589684
resolver
enst
ENST00000297459
resolver
enst
ENST00000899500
resolver
enst
ENST00000899501
resolver
enst
ENST00000919625
resolver
genesymbol
TMEM74
resolver
hgnc
HGNC:26409
resolver
uniprot_entry
TMM74_HUMAN
resolver
amino_acid_sequence
MELHYLAKKSNQADLCDARDWSSRGLPGDQADTAATRAALCCQKQCASTPRATEMEGSKLSSSPASPSSSLQNSTLQPDAFPPGLLHSGNNQITAERKVCNCCSQELETSFTYVDKNINLEQRNRSSPSAKGHNHPGELGWENPNEWSQEAAISLISEEEDDTSSEATSSGKSIDYGFISAILFLVTGILLVIISYIVPREVTVDPNTVAAREMERLEKESARLGAHLDRCVIAGLCLLTLGGVILSCLLMMSMWKGELYRRNRFASSKESAKLYGSFNFRMKTSTNENTLELSLVEEDALAVQS
uniprot
proteins
function
FUNCTION: Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction. {ECO:0000269|PubMed:18294959, ECO:0000269|PubMed:19029833}.
uniprot
proteins
mass_dalton
33338
uniprot
proteins
protein_family
TMEM74 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18294959
uniprot
proteins
pubmed
19029833
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:18294959}; Multi-pass membrane protein {ECO:0000269|PubMed:18294959}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:18294959}; Multi-pass membrane protein {ECO:0000269|PubMed:18294959}.
uniprot
proteins
transmembrane_region
TRANSMEM 178..198; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins