Lrfn1
entrez
80749
canonical
uniprot
Q2WF71
canonical
ensembl
ENSMUSG00000030600
resolver
ensp
ENSMUSP00000057645
resolver
ensp
ENSMUSP00000103923
resolver
ensp
ENSMUSP00000139609
resolver
genesymbol
Lrfn1
resolver
genesymbol_syn
Salm2
resolver
genesymbol_syn
Semo1
resolver
uniprot
Q460M4
resolver
uniprot
Q8C1V9
resolver
uniprot
Q99KT6
resolver
uniprot_entry
LRFN1_MOUSE
resolver
uniprot_sec
Q460M4
resolver
uniprot_sec
Q8C1V9
resolver
uniprot_sec
Q99KT6
resolver
amino_acid_sequence
MAPGPFSSGLFSPPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRKVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGGGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSDIATPGRPGANDSTSERRLVAAELTSSSVLIRWPAQRPVPGIRMYQVQYNSSADDSLVYRMIPSTSQTFLVNDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGGVIVASVLVFIVLLMIRYKVYGDGDSRRIKGTSRTPPRVSHVCSQTNGAGAQQASAPPAPDRYEALREVAVPAAIEAKAMEAEATSTELEVVLGRSLGGSATSLCLLPSEETSGEESRAMTGPRRSRSGALGPPTSAPPTLALVPGGAPARPRPQQRYSFDGDYGALFQSHSYPRRARRTKRHRSTPHLDGAGGGAAGEDGDLGLGSARARLAFTSTEWMLESTV
uniprot
proteins
function
FUNCTION: Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1. {ECO:0000269|PubMed:16828986, ECO:0000269|PubMed:18585462}.
uniprot
proteins
mass_dalton
81945
uniprot
proteins
mutagenesis
MUTAGEN 760..766; /note="Missing: Decreased promotion of neurite outgrowth. No effect on homomeric interactions."; /evidence="ECO:0000269|PubMed:18227064, ECO:0000269|PubMed:18585462
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:16828986}.
uniprot
proteins
protein_family
LRFN family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16495444
uniprot
proteins
pubmed
16630835
uniprot
proteins
pubmed
16828986
uniprot
proteins
pubmed
18227064
uniprot
proteins
pubmed
18585462
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
766
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Postsynaptic density membrane {ECO:0000250}. Note=Detected in excitatory, but not inhibitory, synaptic plasma membrane. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 537..557; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins