Twist2
entrez
13345
canonical
uniprot
Q9D030
canonical
ensembl
ENSMUSG00000007805
resolver
ensp
ENSMUSP00000007949
resolver
ensp
ENSMUSP00000139531
resolver
enst
ENSMUST00000007949
resolver
enst
ENSMUST00000186075
resolver
genesymbol
Twist2
resolver
genesymbol_syn
Dermo1
resolver
uniprot
A0A087WNX2
resolver
uniprot
A5D6P6
resolver
uniprot_entry
A0A087WNX2_MOUSE
resolver
uniprot_entry
A5D6P6_MOUSE
resolver
uniprot_entry
TWST2_MOUSE
resolver
amino_acid_sequence
MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAYSVWRMEGAWSMSASH
uniprot
proteins
function
FUNCTION: Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors (By similarity). {ECO:0000250, ECO:0000269|PubMed:11809751, ECO:0000269|PubMed:12553906, ECO:0000269|PubMed:7589808}.
uniprot
proteins
mass_dalton
18140
uniprot
proteins
mutagenesis
MUTAGEN 86; /note="F->P: Abrogates transcriptional repression of MYOD1."; /evidence="ECO:0000269|PubMed:11809751
uniprot
proteins
pubmed
11809751
uniprot
proteins
pubmed
12553906
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
7589808
uniprot
proteins
sequence_length
160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11809751}. Cytoplasm {ECO:0000269|PubMed:11809751}. Note=Mainly nuclear during embryonic development. Cytoplasmic in adult tissues.
uniprot
proteins