Mtarc1
entrez
66112
canonical
uniprot
Q9CW42
canonical
ensembl
ENSMUSG00000026621
resolver
ensp
ENSMUSP00000035804
resolver
enst
ENSMUST00000048462
resolver
genesymbol
Mtarc1
resolver
genesymbol_syn
Marc1
resolver
genesymbol_syn
Mosc1
resolver
uniprot
Q8R2L6
resolver
uniprot_entry
MARC1_MOUSE
resolver
uniprot_sec
Q8R2L6
resolver
amino_acid_sequence
MGAGSWALTLFGFSAFRVPGQPRSTWLGVAALGLAAVALGTVAWRRARPRRRRRLQQVGTVAQLWIYPIKSCKGLSVSEAECTAMGLRYGHLRDRFWLVINEEGNMVTARQEPRLVLISLTCEDDTLTLSAAYTKDLLLPITPPATNPLLQCRVHGLEIQGRDCGEDAAQWVSSFLKMQSCRLVHFEPHMRPRSSRQMKAVFRTKDQVAYSDASPFLVLSEASLEDLNSRLERRVKATNFRPNIVISGCGVYAEDSWNEVLIGDVELKRVMACTRCLLTTVDPDTGISDRKEPLETLKSYRLCDPSEQALYGKLPIFGQYFALENPGTIRVGDPVYLLGQ
uniprot
proteins
ec_number
1.7.-.-
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction. {ECO:0000250|UniProtKB:Q5VT66}.
uniprot
proteins
mass_dalton
37979
uniprot
proteins
pubmed
12865426
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q5VT66}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q5VT66}. Membrane {ECO:0000250|UniProtKB:Q5VT66}; Lipid-anchor {ECO:0000250|UniProtKB:Q5VT66}. Note=Mitochondrial import is mediated by AA 1-40 and requires ATP. {ECO:0000250|UniProtKB:Q5VT66}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..44; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins