Rnf167
entrez
360554
canonical
uniprot
Q5XIL0
canonical
ensembl
ENSRNOG00000003879
resolver
ensembl
ENSRNOG00055030005
resolver
ensembl
ENSRNOG00060024672
resolver
ensembl
ENSRNOG00065029151
resolver
ensp
ENSRNOP00000005242
resolver
ensp
ENSRNOP00000087224
resolver
ensp
ENSRNOP00055042933
resolver
ensp
ENSRNOP00060035396
resolver
ensp
ENSRNOP00065041389
resolver
enst
ENSRNOT00000005242
resolver
enst
ENSRNOT00055051996
resolver
enst
ENSRNOT00060042724
resolver
enst
ENSRNOT00065050369
resolver
genesymbol
Rnf167
resolver
uniprot_entry
RN167_RAT
resolver
amino_acid_sequence
MHPAAFPLPVVVATVLWGAAPIRGLIRATSEHNASMDFADLPALFGATLSDEGLQGFLVEAHPENACSPIAPPPSAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNVNSNELLNMVWNSEEIQQQIWIPSVFIGERSAEYLRALFVYEKGARVLLVPDNSFPLGYYLIPFTGIVGLLVLAMGTVLIVRCIQHRKRLQRNRLTKEQLKQIPTHDYQKGDEYDVCAICLDEYEDGDKLRILPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEEQEEETQGQEEEGDEGEPRDQPASEWTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPSPSPSSAALA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway. Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1. Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex. Also involved in protein trafficking and localization. Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2. Does not catalyze ubiquitination of GluA1/GRIA1. Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3. Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B. Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18. Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N. {ECO:0000250|UniProtKB:Q9H6Y7}.
uniprot
proteins
mass_dalton
38216
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9H6Y7}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated in vitro in the presence of UBE2D1 and UBE2E1. {ECO:0000250|UniProtKB:Q9H6Y7}.
uniprot
proteins
protein_family
Godzilla family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9H6Y7}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:Q9H6Y7}; Single-pass type I membrane protein {ECO:0000255}. Endomembrane system {ECO:0000250|UniProtKB:Q9H6Y7}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9H6Y7}; Single-pass type I membrane protein {ECO:0000255}. Note=Targeted to cytoplasmic membranes; mainly localizes to lysosomal membrane. A subpopulation localizes to the cell membrane of neurons. {ECO:0000250|UniProtKB:Q9H6Y7}.
uniprot
proteins
transmembrane_region
TRANSMEM 174..194; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins