Il19
entrez
329244
canonical
uniprot
Q8CJ70
canonical
ensembl
ENSMUSG00000016524
resolver
ensp
ENSMUSP00000016668
resolver
ensp
ENSMUSP00000108084
resolver
ensp
ENSMUSP00000139406
resolver
ensp
ENSMUSP00000141175
resolver
enst
ENSMUST00000016668
resolver
enst
ENSMUST00000112465
resolver
enst
ENSMUST00000187410
resolver
enst
ENSMUST00000187916
resolver
genesymbol
Il19
resolver
uniprot
A0A087WST1
resolver
uniprot
Q14BK1
resolver
uniprot_entry
A0A087WST1_MOUSE
resolver
uniprot_entry
IL19_MOUSE
resolver
uniprot_entry
Q14BK1_MOUSE
resolver
amino_acid_sequence
MKTQCASTWLLGMTLILCSVHIYSLRRCLISVDMRLIEKSFHEIKRAMQTKDTFKNVTILSLENLRSIKPGDVCCMTNNLLTFYRDRVFQDHQERSLEVLRRISSIANSFLCVQKSLERCQVHRQCNCSQEATNATRIIHDNYNQLEVSSAALKSLGELNILLAWIDRNHLETPAA
uniprot
proteins
function
FUNCTION: Cytokine that functions as an anti-inflammatory and proangiogenic factor (PubMed:12370360, PubMed:27053520). Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL5 (PubMed:15557163). Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (PubMed:33684929). Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB. In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3 (By similarity). {ECO:0000250|UniProtKB:Q9UHD0, ECO:0000269|PubMed:12370360, ECO:0000269|PubMed:15557163, ECO:0000269|PubMed:27053520, ECO:0000269|PubMed:33684929}.
uniprot
proteins
mass_dalton
20288
uniprot
proteins
protein_family
IL-10 family
uniprot
proteins
pubmed
12370360
uniprot
proteins
pubmed
15557163
uniprot
proteins
pubmed
19834971
uniprot
proteins
pubmed
27053520
uniprot
proteins
pubmed
33684929
uniprot
proteins
sequence_length
176
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins