AGRP
entrez
181
canonical
uniprot
O00253
canonical
ensembl
ENSG00000159723
resolver
ensp
ENSP00000290953
resolver
ensp
ENSP00000638496
resolver
ensp
ENSP00000638497
resolver
enst
ENST00000290953
resolver
enst
ENST00000968437
resolver
enst
ENST00000968438
resolver
genesymbol
AGRP
resolver
genesymbol
AgRP
resolver
genesymbol_syn
AGRP
resolver
genesymbol_syn
AGRT
resolver
genesymbol_syn
ART
resolver
hgnc
HGNC:330
resolver
uniprot
C6SUN5
resolver
uniprot
O15459
resolver
uniprot
Q2TBD9
resolver
uniprot_entry
AGRP_HUMAN
resolver
uniprot_entry
C6SUN5_HUMAN
resolver
uniprot_sec
O15459
resolver
uniprot_sec
Q2TBD9
resolver
amino_acid_sequence
MLTAAVLSCALLLALPATRGAQMGLAPMEGIRRPDQALLPELPGLGLRAPLKKTTAEQAEEDLLQEAQALAEVLDLQDREPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTAMNPCSRT
uniprot
proteins
disease_involvement
DISEASE: Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Signaling protein that functions as an antagonist of melanocyte-stimulating-hormone receptors MC3R and MC4R by precluding agonist-induced signaling, thereby inhibiting cAMP production within the hypothalamus and adrenal gland (PubMed:10371151, PubMed:11145747, PubMed:9311920, PubMed:9892020). Involved in the control of feeding behavior via the central melanocortin system (PubMed:15927146, PubMed:9311920). Has very low activity towards MC5R (PubMed:9311920, PubMed:9892020). Also promotes endocytosis of MC3R and MC4R in an arrestin-dependent mechanism (PubMed:17041250). {ECO:0000269|PubMed:10371151, ECO:0000269|PubMed:11145747, ECO:0000269|PubMed:15927146, ECO:0000269|PubMed:17041250, ECO:0000269|PubMed:9311920, ECO:0000269|PubMed:9892020}.
uniprot
proteins
mass_dalton
14440
uniprot
proteins
mutagenesis
MUTAGEN 79..82; /note="REPR->AEPA: Cleavage is blocked."; /evidence="ECO:0000269|PubMed:16384863"; MUTAGEN 85..86; /note="RR->AA: No effect on cleavage."; /evidence="ECO:0000269|PubMed:16384863"; MUTAGEN 86..89; /note="RCVR->ACVA: No effect on cleavage."; /evidence="ECO:0000269|PubMed:16384863"; MUTAGEN 111; /note="R->A: Abolishes inhibition of cAMP production in response to melanocortin receptor stimulation."; /evidence="ECO:0000269|PubMed:10371151
uniprot
proteins
pubmed
10371151
uniprot
proteins
pubmed
11145747
uniprot
proteins
pubmed
11326303
uniprot
proteins
pubmed
11602360
uniprot
proteins
pubmed
11747427
uniprot
proteins
pubmed
12056887
uniprot
proteins
pubmed
12213871
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15927146
uniprot
proteins
pubmed
16384863
uniprot
proteins
pubmed
17041250
uniprot
proteins
pubmed
17185225
uniprot
proteins
pubmed
9119224
uniprot
proteins
pubmed
9311920
uniprot
proteins
pubmed
9724530
uniprot
proteins
pubmed
9892020
uniprot
proteins
sequence_length
132
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15927146}. Golgi apparatus lumen {ECO:0000269|PubMed:15927146}.
uniprot
proteins