MRAP2
entrez
112609
canonical
uniprot
Q96G30
canonical
ensembl
ENSG00000135324
resolver
ensp
ENSP00000257776
resolver
ensp
ENSP00000525381
resolver
ensp
ENSP00000525382
resolver
ensp
ENSP00000525383
resolver
ensp
ENSP00000525384
resolver
ensp
ENSP00000525385
resolver
ensp
ENSP00000525386
resolver
ensp
ENSP00000600297
resolver
ensp
ENSP00000600298
resolver
ensp
ENSP00000600299
resolver
ensp
ENSP00000638973
resolver
ensp
ENSP00000638974
resolver
enst
ENST00000257776
resolver
enst
ENST00000855322
resolver
enst
ENST00000855323
resolver
enst
ENST00000855324
resolver
enst
ENST00000855325
resolver
enst
ENST00000855326
resolver
enst
ENST00000855327
resolver
enst
ENST00000930238
resolver
enst
ENST00000930239
resolver
enst
ENST00000930240
resolver
enst
ENST00000968915
resolver
genesymbol
MRAP2
resolver
genesymbol_syn
C6orf117
resolver
hgnc
HGNC:21232
resolver
uniprot
A8K9M1
resolver
uniprot
Q8IXM9
resolver
uniprot
Q8N2D1
resolver
uniprot_entry
MRAP2_HUMAN
resolver
uniprot_sec
A8K9M1
resolver
uniprot_sec
Q8IXM9
resolver
uniprot_sec
Q8N2D1
resolver
amino_acid_sequence
MSAQRLISNRTSQQSASNSDYTWEYEYYEIGPVSFEGLKAHKYSIVIGFWVGLAVFVIFMFFVLTLLTKTGAPHQDNAESSEKRFRMNSFVSDFGRPLEPDKVFSRQGNEESRSLFHCYINEVERLDRAKACHQTTALDSDVQLQEAIRSSGQPEEELNRLMKFDIPNFVNTDQNYFGEDDLLISEPPIVLETKPLSQTSHKDLD
uniprot
proteins
disease_involvement
DISEASE: Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269|PubMed:23869016}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo. {ECO:0000250, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}.
uniprot
proteins
mass_dalton
23548
uniprot
proteins
mutagenesis
MUTAGEN 9; /note="N->Q: Abolishes N-glycosylation."; /evidence="ECO:0000269|PubMed:19329486
uniprot
proteins
protein_family
MRAP family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19329486
uniprot
proteins
pubmed
20371771
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23869016
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19329486}; Single-pass membrane protein {ECO:0000269|PubMed:19329486}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19329486}; Single-pass membrane protein {ECO:0000269|PubMed:19329486}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. {ECO:0000269|PubMed:20371771}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..65; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins