Rab18
entrez
19330
canonical
uniprot
P35293
canonical
ensembl
ENSMUSG00000073639
resolver
ensp
ENSMUSP00000157011
resolver
ensp
ENSMUSP00000157198
resolver
enst
ENSMUST00000234626
resolver
enst
ENSMUST00000234810
resolver
genesymbol
Rab18
resolver
uniprot
A0A3Q4EI12
resolver
uniprot
Q0PD38
resolver
uniprot
Q543V0
resolver
uniprot_entry
A0A3Q4EI12_MOUSE
resolver
uniprot_entry
Q0PD38_MOUSE
resolver
uniprot_entry
RAB18_MOUSE
resolver
uniprot_sec
Q543V0
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factor (GEF) RAB3GAP1-RAB3GAP2 complex at the cis-Golgi membrane which promotes the exchange of bound GDP for free GTP (PubMed:26063829). Regulated by GTPase activating protein (GAP) TBC1D20 at the ER membrane which increases the GTP hydrolysis activity (PubMed:26063829). Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation (By similarity). {ECO:0000250|UniProtKB:Q9NP72, ECO:0000269|PubMed:26063829}.
uniprot
proteins
amino_acid_sequence
MDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVDGNKAKLAIWDTAGQERFRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYCTRNDIVNMLVGNKIDKENREVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESENQNKGVKLSHREESRGGGACGGYCSVL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (By similarity). Also required for maintaining endoplasmic reticulum structure (By similarity). Plays a role in apical endocytosis/recycling (PubMed:7706395). Plays a key role in eye and brain development and neurodegeneration (By similarity). {ECO:0000250|UniProtKB:Q9NP72, ECO:0000269|PubMed:7706395}.
uniprot
proteins
mass_dalton
23035
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1555775
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26063829
uniprot
proteins
pubmed
7706395
uniprot
proteins
pubmed
7916717
uniprot
proteins
sequence_length
206
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NP72}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q9NP72}. Lipid droplet {ECO:0000250|UniProtKB:Q9NP72}. Apical cell membrane {ECO:0000269|PubMed:7706395}.
uniprot
proteins