KATNA1
entrez
11104
canonical
uniprot
O75449
canonical
ensembl
ENSG00000186625
resolver
ensp
ENSP00000335106
resolver
ensp
ENSP00000335180
resolver
ensp
ENSP00000356381
resolver
ensp
ENSP00000524107
resolver
ensp
ENSP00000524108
resolver
ensp
ENSP00000524113
resolver
genesymbol
KATNA1
resolver
hgnc
HGNC:6216
resolver
uniprot
A8K7S5
resolver
uniprot
E1P5A3
resolver
uniprot
Q5TFA8
resolver
uniprot
Q5TFA9
resolver
uniprot
Q86VN2
resolver
uniprot
Q9NU52
resolver
uniprot_entry
A8K7S5_HUMAN
resolver
uniprot_entry
KTNA1_HUMAN
resolver
uniprot_sec
E1P5A3
resolver
uniprot_sec
Q5TFA8
resolver
uniprot_sec
Q5TFA9
resolver
uniprot_sec
Q86VN2
resolver
uniprot_sec
Q9NU52
resolver
activity_regulation
ACTIVITY REGULATION: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1. {ECO:0000255|HAMAP-Rule:MF_03023}.
uniprot
proteins
amino_acid_sequence
MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFGSC
uniprot
proteins
ec_number
5.6.1.1
uniprot
proteins
function
FUNCTION: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226, ECO:0000269|PubMed:19287380}.
uniprot
proteins
mass_dalton
55965
uniprot
proteins
mutagenesis
MUTAGEN 255; /note="K->A: Abolishes ATP dependent microtubule severing activity and localization to spindle poles."; /evidence="ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226"; MUTAGEN 308; /note="D->N: Abolishes ATP dependent microtubule severing activity and localization to spindle poles; when associated with N-309."; /evidence="ECO:0000269|PubMed:10751153"; MUTAGEN 309; /note="E->N: Abolishes ATP dependent microtubule severing activity and localization to spindle poles; when associated with N-308."; /evidence="ECO:0000269|PubMed:10751153
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:19261606, ECO:0000269|PubMed:19287380}.; PTM: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:19261606}.
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
protein_family
Katanin p60 subunit A1 subfamily
uniprot
proteins
pubmed
10751153
uniprot
proteins
pubmed
11870226
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19261606
uniprot
proteins
pubmed
19287380
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24486153
uniprot
proteins
pubmed
26929214
uniprot
proteins
pubmed
28386021
uniprot
proteins
pubmed
9658175
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:26929214, ECO:0000269|PubMed:9658175}. Midbody {ECO:0000269|PubMed:19261606}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03023}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:26929214, ECO:0000269|PubMed:9658175}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:26929214}. Note=Predominantly cytoplasmic (PubMed:9658175). Localized diffusely in the cytoplasm during the interphase (PubMed:10751153). During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase and telophase is localized at the midbody region (PubMed:19261606). Also localized to the interphase centrosome and the mitotic spindle poles (By similarity). Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1 (PubMed:10751153). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (PubMed:26929214). {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:19261606, ECO:0000269|PubMed:26929214, ECO:0000269|PubMed:9658175}.
uniprot
proteins