Dsc3
entrez
13507
canonical
uniprot
P55850
canonical
ensembl
ENSMUSG00000059898
resolver
ensp
ENSMUSP00000111514
resolver
ensp
ENSMUSP00000153261
resolver
genesymbol
Dsc3
resolver
uniprot
G5E8S6
resolver
uniprot
O55110
resolver
uniprot
O55122
resolver
uniprot_entry
DSC3_MOUSE
resolver
uniprot_sec
G5E8S6
resolver
uniprot_sec
O55110
resolver
uniprot_sec
O55122
resolver
amino_acid_sequence
MVVPEFRSPQCRALCTKLLLTLWVFSFVGEACKKVTFHVPSTLEADKIIGRVSLKECLSSADGIMPSDPDFRVLDDGSVYPTRAVVLSDEKRSFTIQLSDSKMQTQKEIPVILEHKKKVLKKRHTKETVLRRSKRRWAPIPCSMQENSLGPFPLFLQQVQSDAAQNYTVFYSISGRGADQEPLNWFFIERDTGNLYCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIKIEDENDNYPLFTEAIYAFEVPEGSRLGTVVGTVCATDKDEPDTMHTRLKYSILEQTPPSPGLFSVHPDTGVITTVSHYMDREVVDKYKLIMKVQDMNGQFFGLISTSTCIITVQDSNDNAPTFRQNTYETAVEENTYNVEILRIPVDDKDMINTANWKANFTILKGNENGWFKITTDPVTNEGVLCVVKPLDYEENRQVTLEIGVNNEAPFIKDVANRIPTMNRAMVTVHVKDQNEGPECKPPEQYVRIKENSAVGSKINGYKAYDPETKNSNGLRYKKLQDPKDWVSIEEVSGLLTISKTLDREIMAPRNDMYNITVMAIDQEGKSCTGTLAVNIEDVNDNAPEIIQDYIVICKPKMGYTDISAVDPDEPIHGPPFQFNLANTSPEVNRIWTLNQVNDTAARLSYQKTADVQIYNVPVTVKDRAGQSATKILRVNLCDCTHPSQCPLRSRSAGITLGKWAILAILLGIALLFSVLLTLVCGVVTARKGKHFPEDLAQQNLIISNTEAPGDDRVCSANGFTTHTANNSSQGFCGTMGSGMRNGGQETIEMMKGHQTLDSCRVAGHHHTLDSGRGGHMDTDNCRYTYSEWHSFTQPRLGEKLHVCNQNEDHIPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEEGLDFLNNLEPKFLTLAETCTKR
uniprot
proteins
function
FUNCTION: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:18682494). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (PubMed:18682494). Essential for successful completion of embryo compaction and development beyond the 8-cell stage (PubMed:16418220). {ECO:0000269|PubMed:16418220, ECO:0000269|PubMed:18682494, ECO:0000269|PubMed:38395410}.
uniprot
proteins
mass_dalton
100203
uniprot
proteins
pubmed
16170054
uniprot
proteins
pubmed
16418220
uniprot
proteins
pubmed
18682494
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
38395410
uniprot
proteins
pubmed
9389456
uniprot
proteins
pubmed
9404003
uniprot
proteins
sequence_length
896
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16418220}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, desmosome {ECO:0000269|PubMed:38395410}. Cytoplasm {ECO:0000269|PubMed:16418220}. Note=Expressed in the cytoplasm and at the cell membrane of oocytes. {ECO:0000269|PubMed:16418220}.
uniprot
proteins
transmembrane_region
TRANSMEM 696..716; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins