Dctpp1
entrez
66422
canonical
uniprot
Q9QY93
canonical
ensembl
ENSMUSG00000042462
resolver
ensp
ENSMUSP00000047845
resolver
enst
ENSMUST00000035276
resolver
genesymbol
Dctpp1
resolver
genesymbol_syn
Tdrg-TL1
resolver
uniprot_entry
DCTP1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by divalent calcium or cadmium ions. {ECO:0000269|PubMed:17320107}.
uniprot
proteins
amino_acid_sequence
MSTAGDGERGTVGQEDSAAARPFRFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKSDTEPGPQAWPPKERAALQEELSDVLIYLVALAARCHVDLPQAVISKMDTNRQRYPVHLSRGSACKYTDLPRGTISENQAVGAGDPASELRDQAST
uniprot
proteins
ec_number
3.6.1.12
uniprot
proteins
function
FUNCTION: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:17320107, ECO:0000269|PubMed:19220460}.
uniprot
proteins
mass_dalton
18795
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="H->A: Reduces affinity for substrate and catalytic activity by about 50%."; /evidence="ECO:0000269|PubMed:17320107"; MUTAGEN 47; /note="W->I: Reduces affinity for substrate and catalytic activity by about 50%."; /evidence="ECO:0000269|PubMed:17320107"; MUTAGEN 63; /note="E->Q: Loss of activity."; /evidence="ECO:0000269|PubMed:17320107"; MUTAGEN 66; /note="E->Q: Loss of activity."; /evidence="ECO:0000269|PubMed:17320107"; MUTAGEN 73; /note="W->I: Reduces affinity for substrate and catalytic activity by about 50%."; /evidence="ECO:0000269|PubMed:17320107"; MUTAGEN 95; /note="E->Q: Loss of activity."; /evidence="ECO:0000269|PubMed:17320107"; MUTAGEN 98; /note="D->N: Loss of activity."; /evidence="ECO:0000269|PubMed:17320107"; MUTAGEN 102; /note="Y->I: Reduces affinity for substrate and catalytic activity by about 50%."; /evidence="ECO:0000269|PubMed:17320107
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17320107
uniprot
proteins
pubmed
17850744
uniprot
proteins
pubmed
19220460
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
170
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19220460}. Note=Not detected in mitochondrion and nucleus. {ECO:0000269|PubMed:19220460}.
uniprot
proteins