GASK1A
entrez
729085
canonical
uniprot
Q9UFP1
canonical
ensembl
ENSG00000144649
resolver
ensp
ENSP00000273146
resolver
ensp
ENSP00000407301
resolver
enst
ENST00000273146
resolver
enst
ENST00000430121
resolver
genesymbol
GASK1A
resolver
genesymbol_syn
C3orf41
resolver
genesymbol_syn
FAM198A
resolver
hgnc
HGNC:24485
resolver
uniprot
B3KR48
resolver
uniprot_entry
GAK1A_HUMAN
resolver
uniprot_sec
B3KR48
resolver
amino_acid_sequence
MASWLRRKLRGKRRPVIAFCLLMILSAMAVTRFPPQRPSAGPDPGPMEPQGVTGAPATHIRQALSSSRRQRARNMGFWRSRALPRNSILVCAEEQGHRARVDRSRESPGGDLRHPGRVRRDITLSGHPRLSTQHVVLLREDEVGDPGTKDLGHPQHGSPIQETQSEVVTLVSPLPGSDMAALPAWRATSGLTLWPHTAEGRDLLGAENRALTGGQQAEDPTLASGAHQWPGSVEKLQGSVWCDAETLLSSSRTGGQAPPWLTDHDVQMLRLLAQGEVVDKARVPAHGQVLQVGFSTEAALQDLSSPRLSQLCSQGLCGLIKRPGDLPEVLSFHVDRVLGLRRSLPAVARRFHSPLLPYRYTDGGARPVIWWAPDVQHLSDPDEDQNSLALGWLQYQALLAHSCNWPGQAPCPGIHHTEWARLALFDFLLQVHDRLDRYCCGFEPEPSDPCVEERLREKCQNPAELRLVHILVRSSDPSHLVYIDNAGNLQHPEDKLNFRLLEGIDGFPESAVKVLASGCLQNMLLKSLQMDPVFWESQGGAQGLKQVLQTLEQRGQVLLGHIQKHNLTLFRDEDP
uniprot
proteins
mass_dalton
63637
uniprot
proteins
mutagenesis
MUTAGEN 119..120; /note="RR->AA: Abolishes proteolytic cleavage; when associated with A-437."; /evidence="ECO:0000269|PubMed:30188967"; MUTAGEN 437; /note="R->A: Abolishes proteolytic cleavage; when associated with 119-A-A-120."; /evidence="ECO:0000269|PubMed:30188967
uniprot
proteins
post_translational_modification
PTM: O-glycosylated with core 1 or possibly core 8 glycans. {ECO:0000269|PubMed:22171320}.; PTM: Proteolytically cleaved. Cleaved at Arg-120 and Arg-437 leading to a processed mature product of 35 kDa. The cleavage takes place in the Golgi apparatus. {ECO:0000269|PubMed:30188967}.
uniprot
proteins
protein_family
GASK family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
22171320
uniprot
proteins
pubmed
30188967
uniprot
proteins
sequence_length
575
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q3UY90}. Golgi apparatus {ECO:0000250|UniProtKB:Q3UY90}. Membrane, caveola {ECO:0000269|PubMed:30188967}. Note=Requires caveolae biogenesis to be secreted from the endoplasmic reticulum going through the Golgi apparatus where is post-translationally processed to the mature form. {ECO:0000250|UniProtKB:Q3UY90}.
uniprot
proteins