GCNT1
entrez
2650
canonical
uniprot
Q02742
canonical
ensembl
ENSG00000187210
resolver
ensp
ENSP00000365920
resolver
ensp
ENSP00000390703
resolver
ensp
ENSP00000415454
resolver
ensp
ENSP00000559426
resolver
ensp
ENSP00000559427
resolver
ensp
ENSP00000559428
resolver
ensp
ENSP00000559429
resolver
ensp
ENSP00000559430
resolver
ensp
ENSP00000559431
resolver
ensp
ENSP00000559432
resolver
ensp
ENSP00000559433
resolver
ensp
ENSP00000605272
resolver
ensp
ENSP00000605273
resolver
ensp
ENSP00000605274
resolver
ensp
ENSP00000605275
resolver
ensp
ENSP00000605276
resolver
ensp
ENSP00000605277
resolver
ensp
ENSP00000605278
resolver
ensp
ENSP00000605279
resolver
ensp
ENSP00000605280
resolver
ensp
ENSP00000605281
resolver
ensp
ENSP00000605282
resolver
ensp
ENSP00000605283
resolver
ensp
ENSP00000630847
resolver
ensp
ENSP00000630848
resolver
enst
ENST00000376730
resolver
enst
ENST00000442371
resolver
enst
ENST00000444201
resolver
enst
ENST00000889367
resolver
enst
ENST00000889368
resolver
enst
ENST00000889369
resolver
enst
ENST00000889370
resolver
enst
ENST00000889371
resolver
enst
ENST00000889372
resolver
enst
ENST00000889373
resolver
enst
ENST00000889374
resolver
enst
ENST00000935213
resolver
enst
ENST00000935214
resolver
enst
ENST00000935215
resolver
enst
ENST00000935216
resolver
enst
ENST00000935217
resolver
enst
ENST00000935218
resolver
enst
ENST00000935219
resolver
enst
ENST00000935220
resolver
enst
ENST00000935221
resolver
enst
ENST00000935222
resolver
enst
ENST00000935223
resolver
enst
ENST00000935224
resolver
enst
ENST00000960788
resolver
enst
ENST00000960789
resolver
genesymbol
GCNT1
resolver
genesymbol_syn
NACGT2
resolver
hgnc
HGNC:4203
resolver
uniprot
Q6DJZ4
resolver
uniprot_entry
GCNT1_HUMAN
resolver
uniprot_sec
Q6DJZ4
resolver
amino_acid_sequence
MLRTLLRRRLFSYPTKYYFMVLVLSLITFSVLRIHQKPEFVSVRHLELAGENPSSDINCTKVLQGDVNEIQKVKLEILTVKFKKRPRWTPDDYINMTSDCSSFIKRRKYIVEPLSKEEAEFPIAYSIVVHHKIEMLDRLLRAIYMPQNFYCIHVDTKSEDSYLAAVMGIASCFSNVFVASRLESVVYASWSRVQADLNCMKDLYAMSANWKYLINLCGMDFPIKTNLEIVRKLKLLMGENNLETERMPSHKEERWKKRYEVVNGKLTNTGTVKMLPPLETPLFSGSAYFVVSREYVGYVLQNEKIQKLMEWAQDTYSPDEYLWATIQRIPEVPGSLPASHKYDLSDMQAVARFVKWQYFEGDVSKGAPYPPCDGVHVRSVCIFGAGDLNWMLRKHHLFANKFDVDVDLFAIQCLDEHLRHKALETLKH
uniprot
proteins
ec_number
2.4.1.102
uniprot
proteins
function
FUNCTION: Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine (GlcNAc) moiety in beta1-6 linkage from UDP-GlcNAc onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan (PubMed:1329093, PubMed:23027862). The catalysis is metal ion-independent and occurs with inversion of the anomeric configuration of sugar donor (By similarity). Selectively involved in synthesis of mucin-type core 2 O-glycans that serve as scaffolds for the display of selectin ligand sialyl Lewis X epitope by myeloid cells, with an impact on homeostasis and recruitment to inflammatory sites (By similarity). Can also act on glycolipid substrates. Transfers GlcNAc moiety to GalGb4Cer globosides in a reaction step to the synthesis of stage-specific embryonic antigen 1 (SSEA-1) determinant (By similarity). Can use Galbeta1-3GalNAcalpha1- and Galbeta1-3GalNAcbeta1- oligosaccharide derivatives as acceptor substrates (By similarity). {ECO:0000250|UniProtKB:Q09324, ECO:0000269|PubMed:1329093, ECO:0000269|PubMed:23027862}.
uniprot
proteins
mass_dalton
49799
uniprot
proteins
mutagenesis
MUTAGEN 5..6; /note="LL->AA: Loss of interaction with GOLPH3 and loss of localization to the Golgi."; /evidence="ECO:0000269|PubMed:23027862"; MUTAGEN 7..9; /note="RRR->AAA: Loss of interaction with GOLPH3 and loss of localization to the Golgi."; /evidence="ECO:0000269|PubMed:23027862
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:1329093}.; PATHWAY: Glycolipid biosynthesis. {ECO:0000250|UniProtKB:Q09324}.
uniprot
proteins
protein_family
Glycosyltransferase 14 family
uniprot
proteins
pubmed
1329093
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23027862
uniprot
proteins
pubmed
7579796
uniprot
proteins
sequence_length
428
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:23027862}; Single-pass type II membrane protein {ECO:0000269|PubMed:23027862}. Note=Also detected in the trans-Golgi network.
uniprot
proteins
transmembrane_region
TRANSMEM 10..32; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins