Taf10
entrez
24075
canonical
uniprot
Q8K0H5
canonical
ensembl
ENSMUSG00000043866
resolver
ensp
ENSMUSP00000118105
resolver
ensp
ENSMUSP00000257925
resolver
enst
ENSMUST00000141116
resolver
genesymbol
Taf10
resolver
genesymbol_syn
Taf2h
resolver
genesymbol_syn
Tafii30
resolver
uniprot
Q8C8H2
resolver
uniprot
Q9QYY5
resolver
uniprot_entry
TAF10_MOUSE
resolver
uniprot_sec
Q8C8H2
resolver
uniprot_sec
Q9QYY5
resolver
amino_acid_sequence
MSCSGSGADPEAATACAASVAGPAPLVSAPAALPTSTAAESKASPAGTAGGPVAGVATAGTGPVAARAGEPAERRGPASVAAGGAAPPEGAMSNGVYALPSAANGEVKPVVSSTPLVDFLMQLEDYTPTIPDAVTGYYLNRAGFEASDPRIIRLISLAAQKFISDIANDALQHCKMKGTASGSSRSKSKDRKYTLTMEDLTPALSEYGINVKKPHYFT
uniprot
proteins
function
FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF10 is also component of the PCAF histone acetylase complex, the TATA-binding protein-free TAF complex (TFTC) and the STAGA transcription coactivator-HAT complex (By similarity). May regulate cyclin E expression (PubMed:10469660). {ECO:0000250|UniProtKB:Q12962, ECO:0000269|PubMed:10469660}.
uniprot
proteins
mass_dalton
21841
uniprot
proteins
post_translational_modification
PTM: Monomethylated at Lys-189 by SETD7, leading to increased affinity for RNA polymerase II. {ECO:0000250|UniProtKB:Q12962}.; PTM: Lysine deamination at Lys-189 to form allysine is mediated by LOXL2. Allysine formation by LOXL2 results in release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription. {ECO:0000250|UniProtKB:Q12962}.
uniprot
proteins
protein_family
TAF10 family
uniprot
proteins
pubmed
10469660
uniprot
proteins
pubmed
11438666
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25959397
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q12962}.
uniprot
proteins