PEAK3
entrez
374872
canonical
uniprot
Q6ZS72
canonical
ensembl
ENSG00000188305
resolver
ensp
ENSP00000345102
resolver
enst
ENST00000342063
resolver
genesymbol
PEAK3
resolver
genesymbol_syn
C19orf35
resolver
hgnc
HGNC:24793
resolver
uniprot_entry
PEAK3_HUMAN
resolver
amino_acid_sequence
MSSPEPPTEPPEPDNPTWSTQPTYSNLGQIRAHLLPSKACRLRTPGSLSTNPEPLPPPLPKKILTRTQSLPTRRTLHPSSIQVQPPRRPFLGSHSVDKSQAAVGPACLPAELTFGPADAPLGLSLRDLHSPEAVHTALAARQLQGLRTIYARLRARLMGGHPGPCHPGHSFRLLDSSPCAESGDALYYRVVRAHEDAWHILVAKVPKPGADVPHPWGLELQASLSPHFNLQGLCGLVPEGTLPGAPWRGAVALAAEVPERTVAQWLAEACTQPPEEFVWAVALLLLQLSAALKFLEAWGAALVELRPENLLLVAPRGCATTGPPRLLLTDFGRVCLQPPGPPGSPGPHAPQLGSLLRALLSLAAPSTTPLAAGLELLAAQLTRLRPSASRTRGALQALLWGPGPELRGRGAPLGPWLRALGPWLRVRRGLLVLRLAERAAGGEAPSLEDWLCCEYLAEATESSMGQALALLWD
uniprot
proteins
function
FUNCTION: Probable catalytically inactive kinase (Probable). Interacts with CRK-II and antagonizes CRK-II-signaling. Prevents the formation of CRK-II-dependent membrane ruffling and lamellipodia-like extensions (PubMed:31311869). {ECO:0000269|PubMed:31311869, ECO:0000305|PubMed:31311869}.
uniprot
proteins
mass_dalton
50509
uniprot
proteins
mutagenesis
MUTAGEN 56..60; /note="PPPLP->APPAA: Abolishes interaction with CRK isoform CRK-II. Abolishes inhibition of CRK-II-dependent membrane ruffling."; /evidence="ECO:0000269|PubMed:31311869"; MUTAGEN 146; /note="L->E: Abolishes homodimerization and interaction with CRK isoform CRK-II."; /evidence="ECO:0000269|PubMed:31311869"; MUTAGEN 330; /note="D->N: Strongly decreases homodimerization and interaction with CRK isoform CRK-II."; /evidence="ECO:0000269|PubMed:31311869"; MUTAGEN 436; /note="A->E: Abolishes homodimerization and interaction with CRK isoform CRK-II."; /evidence="ECO:0000269|PubMed:31311869"; MUTAGEN 453; /note="C->E: Abolishes homodimerization and interaction with CRK isoform CRK-II."; /evidence="ECO:0000269|PubMed:31311869
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
31311869
uniprot
proteins
sequence_length
473
uniprot
proteins