CD276
entrez
80381
canonical
uniprot
Q5ZPR3
canonical
ensembl
ENSG00000103855
resolver
ensp
ENSP00000320058
resolver
ensp
ENSP00000320084
resolver
ensp
ENSP00000441087
resolver
ensp
ENSP00000534316
resolver
ensp
ENSP00000623291
resolver
enst
ENST00000537340
resolver
genesymbol
CD276
resolver
genesymbol_syn
B7H3
resolver
hgnc
HGNC:19137
resolver
uniprot
A0A0C4DGH0
resolver
uniprot
A8K9J6
resolver
uniprot
Q6P5Y4
resolver
uniprot
Q6UXI2
resolver
uniprot
Q8NBI8
resolver
uniprot
Q8NC34
resolver
uniprot
Q8NCB6
resolver
uniprot
Q9BXR1
resolver
uniprot_entry
A0A0C4DGH0_HUMAN
resolver
uniprot_entry
A8K9J6_HUMAN
resolver
uniprot_entry
CD276_HUMAN
resolver
uniprot_sec
Q6P5Y4
resolver
uniprot_sec
Q6UXI2
resolver
uniprot_sec
Q8NBI8
resolver
uniprot_sec
Q8NC34
resolver
uniprot_sec
Q8NCB6
resolver
uniprot_sec
Q9BXR1
resolver
amino_acid_sequence
MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYQGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGEGEGSKTALQPLKHSDSKEDDGQEIA
uniprot
proteins
function
FUNCTION: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:12906861, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15314238, ECO:0000269|PubMed:15682454, ECO:0000269|PubMed:15961727}.
uniprot
proteins
mass_dalton
57235
uniprot
proteins
protein_family
BTN/MOG family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
11224528
uniprot
proteins
pubmed
12906861
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14764704
uniprot
proteins
pubmed
15314238
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15682454
uniprot
proteins
pubmed
15961727
uniprot
proteins
pubmed
16049332
uniprot
proteins
pubmed
16274630
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
18650384
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
534
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 467..487; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins