RNF40
entrez
9810
canonical
uniprot
O75150
canonical
ensembl
ENSG00000103549
resolver
ensp
ENSP00000325677
resolver
ensp
ENSP00000350563
resolver
ensp
ENSP00000534955
resolver
ensp
ENSP00000534956
resolver
genesymbol
RNF40
resolver
genesymbol_syn
BRE1B
resolver
genesymbol_syn
KIAA0661
resolver
hgnc
HGNC:16867
resolver
uniprot
A0A024QZG0
resolver
uniprot
A8K6K1
resolver
uniprot
Q6AHZ6
resolver
uniprot
Q6N005
resolver
uniprot
Q7L3T6
resolver
uniprot
Q8N615
resolver
uniprot
Q96T18
resolver
uniprot
Q9BSV9
resolver
uniprot
Q9HC82
resolver
uniprot_entry
A8K6K1_HUMAN
resolver
uniprot_entry
BRE1B_HUMAN
resolver
uniprot_sec
A0A024QZG0
resolver
uniprot_sec
Q6AHZ6
resolver
uniprot_sec
Q6N005
resolver
uniprot_sec
Q7L3T6
resolver
uniprot_sec
Q8N615
resolver
uniprot_sec
Q96T18
resolver
uniprot_sec
Q9BSV9
resolver
uniprot_sec
Q9HC82
resolver
amino_acid_sequence
MSGPGNKRAAGDGGSGPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPCCNTRKKDAVLTKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRIYIS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}.
uniprot
proteins
mass_dalton
113678
uniprot
proteins
mutagenesis
MUTAGEN 109; /note="L->S: Abolishes interaction with RB1."; /evidence="ECO:0000269|PubMed:10944455"; MUTAGEN 111; /note="C->M: Abolishes interaction with RB1."; /evidence="ECO:0000269|PubMed:10944455"; MUTAGEN 113; /note="E->Q: Abolishes interaction with RB1."; /evidence="ECO:0000269|PubMed:10944455
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
BRE1 family
uniprot
proteins
pubmed
10944455
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16307923
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19410543
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21329877
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
37888983
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
1001
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10944455}.
uniprot
proteins