Meak7
entrez
74347
canonical
uniprot
Q8K0P3
canonical
ensembl
ENSMUSG00000034105
resolver
ensp
ENSMUSP00000044430
resolver
ensp
ENSMUSP00000230024
resolver
genesymbol
Meak7
resolver
genesymbol_syn
Kiaa1609
resolver
genesymbol_syn
Tldc1
resolver
uniprot
Q69ZF1
resolver
uniprot_entry
MEAK7_MOUSE
resolver
uniprot_sec
Q69ZF1
resolver
amino_acid_sequence
MGNAKSLSGQKMASRFLPEEQAEVDKLFDVLSSSEGGVATGTFSLEAMKSHVKEALPPAMVTRLYNGMQRVKPTDRTLGSCRSVSREQFTAFLSQLLRGSCEEKGLMVMNMISDAEGPTKTRDVQKFTEDLVASVAHVLTHRHELRGWTCRKSEVPPDSMQAMVAQLLSEMKFQDGYKFQGPQCLDQVCDQAMIEEWVFHVPHVGMFLSVVVHRGLCLLGSSFDPSTLVPECLADQGGRFESILDVLSVIYLSSHLAPEHRQRWRLLFSTQLHGQSFSQLCSHITSQGPSLLVLEDRDGYVFGGFASCSWEVKPQFQGDNRCFLFSIAPRMATHLHTGYNNHFMYLNYGQQTMPNGLGMGGQHHYFGLWVAADFGKGHSKAKPACTTYNSPQLSAQEDFLFDKMEVWGLGNLLEEYEGKNKKSVLDSNPEARSLLEISGRARHSEGLREVPRDED
uniprot
proteins
function
FUNCTION: Activates an alternative mTOR signaling pathway through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration (By similarity). Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome (By similarity). Binds to the vacuolar-type ATPase (V-ATPase) complex, triggering a conformational change and is likely to regulate its activity (By similarity). No effect on V-ATPase activity was observed in vitro in one study although it was suggested that it may have inhibitory activity in vivo (By similarity). However, another study showed that it can promote V-ATPase activity (By similarity). Protects neuronal cells against oxidative stress (PubMed:26668325). {ECO:0000250|UniProtKB:Q6P9B6, ECO:0000269|PubMed:26668325}.
uniprot
proteins
mass_dalton
50845
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
26668325
uniprot
proteins
pubmed
34811399
uniprot
proteins
sequence_length
455
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q6P9B6}. Cytoplasm {ECO:0000250|UniProtKB:Q6P9B6}. Lysosome {ECO:0000250|UniProtKB:Q6P9B6}.
uniprot
proteins