Asz1
entrez
74068
canonical
uniprot
Q8VD46
canonical
ensembl
ENSMUSG00000010796
resolver
ensp
ENSMUSP00000010940
resolver
enst
ENSMUST00000010940
resolver
genesymbol
Asz1
resolver
genesymbol_syn
Gasz
resolver
uniprot
G3X8S0
resolver
uniprot
Q6PD92
resolver
uniprot
Q9JKQ7
resolver
uniprot_entry
ASZ1_MOUSE
resolver
uniprot_sec
G3X8S0
resolver
uniprot_sec
Q6PD92
resolver
uniprot_sec
Q9JKQ7
resolver
amino_acid_sequence
MAAGTLRGLAVAGGGESSDSEDDGWDIGYLDRSSQKLKRSLPVEEKNETFKKALTTGDISLVKELLDSGINVDSSFRYGWTPLMYAASVANAELVRFLLDRGANASFDKDKLTILISACSARGSEEQVLKCVELLLSRNADPNTACRRLMTPIMYAARDGHTQVVALLVAHGAEVNAQDENGYTALTWAARQGHKNVILKLLELGANKMLQTKDGRTPSEIAKRNKHLEIFNFLSLTLNPLEGKLQQLTKEETICKLLATDSDKEKDHIFSPYTAFGDLEIFLHGLGLEHMTDSLKEKDITLRHLLTMKKDELTKNGIASKDQQKILAALKELEVEEINFGKLPEVTKLEISGDEFLNFLLKLNKQCGHLITAVQNIITELPVNSHKIVLEWASPRNFTSVCEELVSNVEDLNEEVCRLKELIQKMQNERENDPTHIPLVEEVSTWKTRILKRSAVTVCGFGLLLFIGKLTLQRK
uniprot
proteins
function
FUNCTION: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation. {ECO:0000269|PubMed:19730684}.
uniprot
proteins
mass_dalton
52984
uniprot
proteins
pubmed
10655503
uniprot
proteins
pubmed
12040005
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19730684
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
475
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12040005, ECO:0000269|PubMed:19730684}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to pi-bodies, a subset of the nuage which contains primary piRNAs.
uniprot
proteins