POLK
entrez
51426
canonical
uniprot
Q9UBT6
canonical
ensembl
ENSG00000122008
resolver
ensp
ENSP00000241436
resolver
ensp
ENSP00000424174
resolver
ensp
ENSP00000533952
resolver
ensp
ENSP00000533954
resolver
ensp
ENSP00000669326
resolver
ensp
ENSP00000669328
resolver
ensp
ENSP00000669329
resolver
ensp
ENSP00000691545
resolver
genesymbol
POLK
resolver
genesymbol_syn
DINB1
resolver
hgnc
HGNC:9183
resolver
uniprot
B2RBD2
resolver
uniprot
Q5Q9G5
resolver
uniprot
Q5Q9G6
resolver
uniprot
Q5Q9G7
resolver
uniprot
Q5Q9G8
resolver
uniprot
Q86VJ8
resolver
uniprot
Q8IZY0
resolver
uniprot
Q8IZY1
resolver
uniprot
Q8NB30
resolver
uniprot
Q96L01
resolver
uniprot
Q96Q86
resolver
uniprot
Q96Q87
resolver
uniprot
Q9UHC5
resolver
uniprot_entry
POLK_HUMAN
resolver
uniprot_sec
B2RBD2
resolver
uniprot_sec
Q5Q9G5
resolver
uniprot_sec
Q5Q9G6
resolver
uniprot_sec
Q5Q9G7
resolver
uniprot_sec
Q5Q9G8
resolver
uniprot_sec
Q86VJ8
resolver
uniprot_sec
Q8IZY0
resolver
uniprot_sec
Q8IZY1
resolver
uniprot_sec
Q8NB30
resolver
uniprot_sec
Q96L01
resolver
uniprot_sec
Q96Q86
resolver
uniprot_sec
Q96Q87
resolver
uniprot_sec
Q9UHC5
resolver
amino_acid_sequence
MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKMGSSVENDNPGKEVNKLSEHERSISPLLFEESPSDVQPPGDPFQVNFEEQNNPQILQNSVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSFPNEEDRKHQQRSIIGFLQAGNQALSATECTLEKTDKDKFVKPLEMSHKKSFFDKKRSERKWSHQDTFKCEAVNKQSFQTSQPFQVLKKKMNENLEISENSDDCQILTCPVCFRAQGCISLEALNKHVDECLDGPSISENFKMFSCSHVSATKVNKKENVPASSLCEKQDYEAHPKIKEISSVDCIALVDTIDNSSKAESIDALSNKHSKEECSSLPSKSFNIEHCHQNSSSTVSLENEDVGSFRQEYRQPYLCEVKTGQALVCPVCNVEQKTSDLTLFNVHVDVCLNKSFIQELRKDKFNPVNQPKESSRSTGSSSGVQKAVTRTKRPGLMTKYSTSKKIKPNNPKHTLDIFFK
uniprot
proteins
ec_number
2.7.7.7
uniprot
proteins
function
FUNCTION: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. {ECO:0000269|PubMed:10620008, ECO:0000269|PubMed:11024016, ECO:0000269|PubMed:12145297, ECO:0000269|PubMed:12444249, ECO:0000269|PubMed:12952891, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:15533436, ECO:0000269|PubMed:28297716}.
uniprot
proteins
mass_dalton
98809
uniprot
proteins
mutagenesis
MUTAGEN 198; /note="D->A: Loss of DNA polymerase activity; when associated with A-199."; /evidence="ECO:0000269|PubMed:11024016"; MUTAGEN 199; /note="E->A: Loss of DNA polymerase activity; when associated with D-198."; /evidence="ECO:0000269|PubMed:11024016
uniprot
proteins
protein_family
DNA polymerase type-Y family
uniprot
proteins
pubmed
10518552
uniprot
proteins
pubmed
10620008
uniprot
proteins
pubmed
11024016
uniprot
proteins
pubmed
11784855
uniprot
proteins
pubmed
12145297
uniprot
proteins
pubmed
12414988
uniprot
proteins
pubmed
12444249
uniprot
proteins
pubmed
12952891
uniprot
proteins
pubmed
14630940
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15296733
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15533436
uniprot
proteins
pubmed
15661663
uniprot
proteins
pubmed
23143872
uniprot
proteins
pubmed
28297716
uniprot
proteins
pubmed
29186122
uniprot
proteins
sequence_length
870
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12414988, ECO:0000269|PubMed:28297716}. Note=Detected throughout the nucleus and at replication foci (PubMed:12414988). Recruited to DNA damage sites in response to ultraviolet irradiation: N6-methyladenosine (m6A)-containing mRNAs accumulate in the vicinity of DNA damage sites and their presence is required to recruit POLK (PubMed:28297716). {ECO:0000269|PubMed:12414988, ECO:0000269|PubMed:28297716}.
uniprot
proteins