PLAAT4
entrez
5920
canonical
uniprot
Q9UL19
canonical
ensembl
ENSG00000133321
resolver
ensp
ENSP00000255688
resolver
genesymbol
PLAAT4
resolver
genesymbol_syn
RARRES3
resolver
genesymbol_syn
RIG1
resolver
genesymbol_syn
TIG3
resolver
hgnc
HGNC:9869
resolver
uniprot
B2R599
resolver
uniprot
B4DDW2
resolver
uniprot
E7ENZ7
resolver
uniprot
O95200
resolver
uniprot_entry
PLAT4_HUMAN
resolver
uniprot_sec
B2R599
resolver
uniprot_sec
B4DDW2
resolver
uniprot_sec
E7ENZ7
resolver
uniprot_sec
O95200
resolver
amino_acid_sequence
MASPHQEPKPGDLIEIFRLGYEHWALYIGDGYVIHLAPPSEYPGAGSSSVFSVLSNSAEVKRERLEDVVGGCCYRVNNSLDHEYQPRPVEVIISSAKEMVGQKMKYSIVSRNCEHFVTQLRYGKSRCKQVEKAKVEVGVATALGILVVAGCSFAIRRYQKKATA
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
3.1.1.32
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22605381, PubMed:22825852). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:22605381, PubMed:22825852). {ECO:0000269|PubMed:19615464, ECO:0000269|PubMed:22605381, ECO:0000269|PubMed:22825852, ECO:0000303|PubMed:26503625}.
uniprot
proteins
mass_dalton
18179
uniprot
proteins
protein_family
H-rev107 family
uniprot
proteins
pubmed
10687848
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17762858
uniprot
proteins
pubmed
19615464
uniprot
proteins
pubmed
22605381
uniprot
proteins
pubmed
22825852
uniprot
proteins
pubmed
26503625
uniprot
proteins
pubmed
40409913
uniprot
proteins
pubmed
9843971
uniprot
proteins
sequence_length
164
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 135..155; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins