Nrtn
entrez
18188
canonical
uniprot
P97463
canonical
ensembl
ENSMUSG00000039481
resolver
ensp
ENSMUSP00000046512
resolver
enst
ENSMUST00000044752
resolver
genesymbol
Nrtn
resolver
uniprot_entry
NRTN_MOUSE
resolver
amino_acid_sequence
MRRWKAAALVSLICSSLLSVWMCQEGLLLGHRLGPALAPLRRPPRTLDARIARLAQYRALLQGAPDAVELRELSPWAARIPGPRRRAGPRRRRARPGARPCGLRELEVRVSELGLGYTSDETVLFRYCAGACEAAIRIYDLGLRRLRQRRRVRRERARAHPCCRPTAYEDEVSFLDVHSRYHTLQELSARECACV
uniprot
proteins
function
FUNCTION: Growth factor that supports the survival of sympathetic neurons in culture (PubMed:8945474). May regulate the development and maintenance of the CNS (PubMed:8945474). Involved in the development of the neural crest (By similarity). Might control the size of non-neuronal cell population such as haemopoietic cells (PubMed:8945474). Acts by binding to its coreceptor, GFRA2, leading to autophosphorylation and activation of the RET receptor (By similarity). Heparan sulfate-binding is required for signaling (By similarity). {ECO:0000250|UniProtKB:Q99748, ECO:0000269|PubMed:8945474}.
uniprot
proteins
mass_dalton
22219
uniprot
proteins
protein_family
GDNF subfamily
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8945474
uniprot
proteins
sequence_length
195
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8945474}.
uniprot
proteins