Canx
entrez
12330
canonical
uniprot
P35564
canonical
ensembl
ENSMUSG00000020368
resolver
ensp
ENSMUSP00000020637
resolver
ensp
ENSMUSP00000137440
resolver
ensp
ENSMUSP00000203991
resolver
enst
ENSMUST00000020637
resolver
enst
ENSMUST00000179865
resolver
genesymbol
Canx
resolver
uniprot
Q5SUC3
resolver
uniprot_entry
CALX_MOUSE
resolver
uniprot_entry
Q5SUC3_MOUSE
resolver
amino_acid_sequence
MEGKWLLCLLLVLGTAAVEAHDGHDDDAIDIEDDLDDVIEEVEDSKSKSDASTPPSPKVTYKAPVPTGEVYFADSFDRGSLSGWILSKAKKDDTDDEIAKYDGKWEVDEMKETKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTAELSLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGVYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPEDWDERPKIADPDAVKPDDWDEDAPSKIPDEEATKPEGWLDDEPEYIPDPDAEKPEDWDEDMDGEWEAPQIANPKCESAPGCGVWQRPMIDNPNYKGKWKPPMIDNPNYQGIWKPRKIPNPDFFEDLEPFKMTPFSAIGLELWSMTSDIFFDNFIISGDRRVVDDWANDGWGLKKAADGAAEPGVVLQMLEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQSNAMEYKKTDAPQPDVKDEEGKEEEKNKRDEEEEEEKLEEKQKSDAEEDGVTGSQDEEDSKPKAEEDEILNRSPRNRKPRRE
uniprot
proteins
function
FUNCTION: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. {ECO:0000269|PubMed:21747946, ECO:0000269|PubMed:7628443}.
uniprot
proteins
mass_dalton
67278
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-563 by MAPK3/ERK1. Phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity). {ECO:0000250}.; PTM: Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins (By similarity). {ECO:0000250}.; PTM: Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4. {ECO:0000250|UniProtKB:P27824}.
uniprot
proteins
protein_family
Calreticulin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17208939
uniprot
proteins
pubmed
17622165
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
20945367
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21747946
uniprot
proteins
pubmed
32783947
uniprot
proteins
pubmed
7628443
uniprot
proteins
pubmed
8136357
uniprot
proteins
pubmed
8148318
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:7628443}; Single-pass type I membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:P24643}; Single-pass type I membrane protein {ECO:0000255}. Melanosome membrane {ECO:0000250|UniProtKB:P27824}; Single-pass type I membrane protein {ECO:0000255}. Note=The palmitoylated form preferentially localizes to the perinuclear rough ER (By similarity). When bound to CD3 epsilon chains, calnexin's ER retention signal can be masked, permitting it to escape ER retention (By similarity). Localizes to endoplasmic reticulum mitochondria-associated membrane (MAMs) that connect the endoplasmic reticulum and the mitochondria (By similarity). {ECO:0000250|UniProtKB:P24643, ECO:0000250|UniProtKB:P27824}.
uniprot
proteins
transmembrane_region
TRANSMEM 483..503; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins