RAB11FIP3
entrez
9727
canonical
uniprot
O75154
canonical
ensembl
ENSG00000090565
resolver
ensembl
ENSG00000275338
resolver
ensp
ENSP00000262305
resolver
ensp
ENSP00000399644
resolver
ensp
ENSP00000415919
resolver
ensp
ENSP00000654301
resolver
ensp
ENSP00000686484
resolver
ensp
ENSP00000797905
resolver
genesymbol
RAB11FIP3
resolver
genesymbol_syn
ARFO1
resolver
genesymbol_syn
KIAA0665
resolver
hgnc
HGNC:17224
resolver
uniprot
B0QYI8
resolver
uniprot
B0QYT8
resolver
uniprot
B1AHQ0
resolver
uniprot
B4DEI7
resolver
uniprot
B4DZR6
resolver
uniprot
Q4VXV7
resolver
uniprot
Q7Z5E9
resolver
uniprot
Q9H155
resolver
uniprot
Q9H1G0
resolver
uniprot
Q9NUI0
resolver
uniprot_entry
RFIP3_HUMAN
resolver
uniprot_sec
B0QYI8
resolver
uniprot_sec
B0QYT8
resolver
uniprot_sec
B1AHQ0
resolver
uniprot_sec
B4DEI7
resolver
uniprot_sec
B4DZR6
resolver
uniprot_sec
Q4VXV7
resolver
uniprot_sec
Q7Z5E9
resolver
uniprot_sec
Q9H155
resolver
uniprot_sec
Q9H1G0
resolver
uniprot_sec
Q9NUI0
resolver
amino_acid_sequence
MASAPPASPPGSEPPGPDPEPGGPDGPGAAQLAPGPAELRLGAPVGGPDPQSPGLDEPAPGAAADGGARWSAGPAPGLEGGPRDPGPSAPPPRSGPRGQLASPDAPGPGPRSEAPLPELDPLFSWTEEPEECGPASCPESAPFRLQGSSSSHRARGEVDVFSPFPAPTAGELALEQGPGSPPQPSDLSQTHPLPSEPVGSQEDGPRLRAVFDALDGDGDGFVRIEDFIQFATVYGAEQVKDLTKYLDPSGLGVISFEDFYQGITAIRNGDPDGQCYGGVASAQDEEPLACPDEFDDFVTYEANEVTDSAYMGSESTYSECETFTDEDTSTLVHPELQPEGDADSAGGSAVPSECLDAMEEPDHGALLLLPGRPHPHGQSVITVIGGEEHFEDYGEGSEAELSPETLCNGQLGCSDPAFLTPSPTKRLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK
uniprot
proteins
function
FUNCTION: Downstream effector molecule for Rab11 GTPase which is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery (PubMed:15601896, PubMed:16148947, PubMed:17394487, PubMed:17628206, PubMed:18511905, PubMed:19327867, PubMed:20026645, PubMed:25673879, PubMed:26258637, PubMed:31204173). Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex (PubMed:20026645). The functional Rab11-RAB11FIP3-dynein complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle (PubMed:17394487, PubMed:20026645). Facilitates the interaction between dynein and dynactin and activates dynein processivity (PubMed:25035494). Binding with ASAP1 is needed to regulate the pericentrosomal localization of recycling endosomes (By similarity). The Rab11-RAB11FIP3 complex is also implicated in the transport during telophase of vesicles derived from recycling endosomes to the cleavage furrow via centrosome-anchored microtubules, where the vesicles function to deliver membrane during late cytokinesis and abscission (PubMed:15601896, PubMed:16148947). The recruitment of Rab11-RAB11FIP3-containing endosomes to the cleavage furrow and tethering to the midbody is co-mediated by RAB11FIP3 interaction with ARF6-exocyst and RACGAP1-MKLP1 tethering complexes (PubMed:17628206, PubMed:18511905). Also involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which directs preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:26258637, PubMed:31204173). Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin (PubMed:25673879). Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway (PubMed:31204173). May play a role in breast cancer cell motility by regulating actin cytoskeleton (PubMed:19327867). {ECO:0000250|UniProtKB:Q8CHD8, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:16148947, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:17628206, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19327867, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26258637, ECO:0000269|PubMed:31204173}.
uniprot
proteins
mass_dalton
82440
uniprot
proteins
mutagenesis
MUTAGEN 737; /note="Y->S: Abolishes Rab11-binding."; /evidence="ECO:0000269|PubMed:17030804"; MUTAGEN 738; /note="I->E: Abolishes Rab11-binding. Capable of binding to DYNC1LI1. Impaired trafficking towards the pericentrosomal endosomal recycling compartment (ERC)."; /evidence="ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:16148947, ECO:0000269|PubMed:20026645"; MUTAGEN 739; /note="D->A: Abolishes Rab11-binding."; /evidence="ECO:0000269|PubMed:17030804"; MUTAGEN 746; /note="M->S: Abolishes Rab11-binding."; /evidence="ECO:0000269|PubMed:17030804"; MUTAGEN 747; /note="E->A: Abolishes Rab11-binding."; /evidence="ECO:0000269|PubMed:17030804
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-102 by CDK1 during metaphase, and dephosphorylated as cells enter telophase. {ECO:0000269|PubMed:22401586}.
uniprot
proteins
pubmed
11157797
uniprot
proteins
pubmed
11481332
uniprot
proteins
pubmed
11495908
uniprot
proteins
pubmed
12470645
uniprot
proteins
pubmed
12800201
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15158446
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15601896
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16148947
uniprot
proteins
pubmed
17007872
uniprot
proteins
pubmed
17030804
uniprot
proteins
pubmed
17229837
uniprot
proteins
pubmed
17394487
uniprot
proteins
pubmed
17628206
uniprot
proteins
pubmed
18511905
uniprot
proteins
pubmed
19327867
uniprot
proteins
pubmed
20026645
uniprot
proteins
pubmed
22401586
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25035494
uniprot
proteins
pubmed
25673879
uniprot
proteins
pubmed
26258637
uniprot
proteins
pubmed
31204173
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
756
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane. Recycling endosome membrane {ECO:0000269|PubMed:11495908, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:17007872, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:20026645}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15158446, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:18511905}. Cleavage furrow {ECO:0000269|PubMed:15158446, ECO:0000269|PubMed:15601896}. Midbody {ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:16148947, ECO:0000269|PubMed:18511905}. Golgi apparatus membrane {ECO:0000269|PubMed:25673879}; Peripheral membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:25673879}; Peripheral membrane protein {ECO:0000305}. Note=During interphase, localized in vesicles continuously moving from peripheral sorting endosomes in the cell towards the pericentrosomal endosomal recycling compartment (ERC) (PubMed:17394487, PubMed:20026645). In early mitosis remains diffuse and distributed through the cell. The onset of anaphase sequesters these vesicles to the centrosomes at the opposite poles of the cell. During telophase these vesicles move from the centrosomes, to the furrow, and then to the midbody to aid in abscission (PubMed:15158446, PubMed:15601896, PubMed:18511905). Interaction with Rab11 mediates localization to endosomes (PubMed:11495908). Interaction with ARF6 mediates localization to the midbody (PubMed:16148947). Localized to the Golgi and TGN when interacting with RHO in photoreceptors (PubMed:25673879). Localized to rhodopsin transport carriers when interacting with RAB11A and ASAP1 in photoreceptors (PubMed:25673879). {ECO:0000269|PubMed:11495908, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:16148947, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:25673879}.
uniprot
proteins