PCYOX1L
entrez
78991
canonical
uniprot
Q8NBM8
canonical
ensembl
ENSG00000145882
resolver
ensp
ENSP00000274569
resolver
ensp
ENSP00000428512
resolver
ensp
ENSP00000555680
resolver
genesymbol
PCYOX1L
resolver
hgnc
HGNC:28477
resolver
uniprot
Q7Z4S2
resolver
uniprot
Q8NCY5
resolver
uniprot
Q8NF69
resolver
uniprot
Q9BTE8
resolver
uniprot
Q9BWS3
resolver
uniprot_entry
PCYXL_HUMAN
resolver
uniprot_sec
Q7Z4S2
resolver
uniprot_sec
Q8NCY5
resolver
uniprot_sec
Q8NF69
resolver
uniprot_sec
Q9BTE8
resolver
uniprot_sec
Q9BWS3
resolver
amino_acid_sequence
MARAAPLLAALTALLAAAAAGGDAPPGKIAVVGAGIGGSAVAHFLQQHFGPRVQIDVYEKGTVGGRLATISVNKQHYESGAASFHSLSLHMQDFVKLLGLRHRREVVGRSAIFGGEHFMLEETDWYLLNLFRLWWHYGISFLRLQMWVEEVMEKFMRIYKYQAHGYAFSGVEELLYSLGESTFVNMTQHSVAESLLQVGVTQRFIDDVVSAVLRASYGQSAAMPAFAGAMSLAGAQGSLWSVEGGNKLVCSGLLKLTKANVIHATVTSVTLHSTEGKALYQVAYENEVGNSSDFYDIVVIATPLHLDNSSSNLTFAGFHPPIDDVQGSFQPTVVSLVHGYLNSSYFGFPDPKLFPFANILTTDFPSFFCTLDNICPVNISASFRRKQPQEAAVWRVQSPKPLFRTQLKTLFRSYYSVQTAEWQAHPLYGSRPTLPRFALHDQLFYLNALEWAASSVEVMAVAAKNVALLAYNRWYQDLDKIDQKDLMHKVKTEL
uniprot
proteins
ec_number
1.8.3.5
uniprot
proteins
function
FUNCTION: Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. Does not metabolize shorter prenyl chain compounds (Probable). Required in the mevalonate pathway to regulate prenylation and enhances the bactericidal activity of neutrophils (By similarity). Promotes the assembly of the postsynaptic ion channel ASIC1a (By similarity). {ECO:0000250|UniProtKB:B5DEI0, ECO:0000250|UniProtKB:Q8C7K6, ECO:0000305|PubMed:39322016}.
uniprot
proteins
mass_dalton
54646
uniprot
proteins
protein_family
Prenylcysteine oxidase family
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
39322016
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:B5DEI0}.
uniprot
proteins