Baat
entrez
29725
canonical
uniprot
Q63276
canonical
ensembl
ENSRNOG00000007395
resolver
ensembl
ENSRNOG00055020369
resolver
ensembl
ENSRNOG00060006010
resolver
ensembl
ENSRNOG00065010767
resolver
ensp
ENSRNOP00000009777
resolver
ensp
ENSRNOP00055028214
resolver
ensp
ENSRNOP00060007458
resolver
ensp
ENSRNOP00065013366
resolver
enst
ENSRNOT00000009777
resolver
enst
ENSRNOT00055034796
resolver
enst
ENSRNOT00060009944
resolver
enst
ENSRNOT00065017431
resolver
genesymbol
Baat
resolver
uniprot
Q5M8A2
resolver
uniprot_entry
BAAT_RAT
resolver
uniprot_sec
Q5M8A2
resolver
amino_acid_sequence
MAKLTAVPLSALVDEPVHIRVTGLTPFQVVCLQASLKDDKGNLFNSQAFYRASEVGEVDLERDSSLGGDYMGVHPMGLFWSMKPEKLLTRLVKRDVMNRPHKVHIKLCHPYFPVEGKVISSSLDSLILERWYVAPGVTRIHVKEGRIRGALFLPPGEGPFPGVIDLFGGAGGLFEFRASLLASHGFATLALAYWGYDDLPSRLEKVDLEYFEEGVEFLLRHPKVLGPGVGILSVCIGAEIGLSMAINLKQITATVLINGPNFVSSNPHVYRGKVFQPTPCSEEFVTTNALGLVEFYRTFEETADKDSKYCFPIEKAHGHFLFVVGEDDKNLNSKVHAKQAIAQLMKSGKKNWTLLSYPGAGHLIEPPYSPLCSASRMPFVIPSINWGGEVIPHAAAQEHSWKEIQKFLKQHLNPGFNSQL
uniprot
proteins
ec_number
2.3.1.65
uniprot
proteins
ec_number
3.1.2.2
uniprot
proteins
ec_number
3.1.2.27
uniprot
proteins
function
FUNCTION: Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine (PubMed:12951368, PubMed:624713). More efficient at taurine conjugation of cholyl CoA than glycine conjugation (PubMed:12951368, PubMed:624713). Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (By similarity). This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption (By similarity). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids (By similarity). In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (By similarity). {ECO:0000250|UniProtKB:Q14032, ECO:0000269|PubMed:12951368, ECO:0000269|PubMed:624713}.
uniprot
proteins
mass_dalton
46465
uniprot
proteins
protein_family
C/M/P thioester hydrolase family
uniprot
proteins
pubmed
12951368
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
624713
uniprot
proteins
pubmed
7575455
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:12951368}. Cytoplasm, cytosol {ECO:0000269|PubMed:12951368}.
uniprot
proteins