Tmem98
entrez
103743
canonical
uniprot
Q91X86
canonical
ensembl
ENSMUSG00000035413
resolver
ensp
ENSMUSP00000042825
resolver
enst
ENSMUST00000040865
resolver
genesymbol
Tmem98
resolver
uniprot_entry
TMM98_MOUSE
resolver
amino_acid_sequence
METVVIVAIGVLATIFLASFAALVVVCRQRYCRPRDLLQRYDSKPIVDLIGAMETQSEPSELELDDVVITNPHIEAILENEDWIEDASGLMSHCIAILKICHTLTEKLVAMTMGSGAKMKTSASVSDIIVVAKRISPRVDDVVKSMYPPLDPKLLDARTTALLLSVSHLVLVTRNACHLTGGLDWIDQSLSAAEEHLEVLREAALASEPDKSLPNPEGFLQEQSAI
uniprot
proteins
function
FUNCTION: Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation (PubMed:25946230). The secreted form promotes differentiation of T helper 1 cells (Th1) (PubMed:25946230). {ECO:0000269|PubMed:25946230}.
uniprot
proteins
mass_dalton
24684
uniprot
proteins
protein_family
TMEM98 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25946230
uniprot
proteins
pubmed
30249802
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:30249802}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9Y2Y6}. Cell membrane {ECO:0000250|UniProtKB:Q9Y2Y6}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9Y2Y6}. Secreted {ECO:0000269|PubMed:25946230}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:Q9Y2Y6}. Note=Secreted by exosomes through a non-classical pathway. {ECO:0000250|UniProtKB:Q9Y2Y6}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins