Fbp1
entrez
24362
canonical
uniprot
P19112
canonical
ensembl
ENSRNOG00000017597
resolver
ensembl
ENSRNOG00055023469
resolver
ensembl
ENSRNOG00060017927
resolver
ensembl
ENSRNOG00065021873
resolver
ensp
ENSRNOP00000023685
resolver
ensp
ENSRNOP00055032793
resolver
ensp
ENSRNOP00060024914
resolver
ensp
ENSRNOP00065030027
resolver
enst
ENSRNOT00000023685
resolver
enst
ENSRNOT00055040357
resolver
enst
ENSRNOT00060030768
resolver
enst
ENSRNOT00065037220
resolver
genesymbol
Fbp1
resolver
genesymbol_syn
Fbp
resolver
uniprot
Q64594
resolver
uniprot_entry
F16P1_RAT
resolver
uniprot_sec
Q64594
resolver
activity_regulation
ACTIVITY REGULATION: Subject to complex allosteric regulation. The enzyme can assume an active R-state, or an inactive T-state. Intermediate conformations may exist. AMP acts as an allosteric inhibitor. AMP binding affects the turnover of bound substrate and not the affinity for substrate. Fructose 2,6-bisphosphate acts as a competitive inhibitor. Fructose 2,6-bisphosphate and AMP have synergistic effects. {ECO:0000269|PubMed:1313010}.
uniprot
proteins
amino_acid_sequence
MVDHAPFETDISTLTRFVLEEGRKAGGTGEMTQLLNSLCTAIKAISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEEDTHAIIIEPEKRGKYVVCFDPLDGSSNIDCLASIGTIFGIYRKTSANEPSEKDALQPGRNLVAAGYALYGSATMLVLAMNCGVNCFMLDPSIGEFILVDRDVKIKKKGNIYSINEGYAKDFDPAINEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKNPSGKLRLLYECNPIAYVMEKAGGLATTGNEDILDIVPTEIHQKAPVIMGSTEDVQEFLEIYNKDKAKSRPSLPLPQSRARESPVHSICDELF
uniprot
proteins
ec_number
3.1.3.11
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000250|UniProtKB:P09467}.
uniprot
proteins
mass_dalton
39609
uniprot
proteins
mutagenesis
MUTAGEN 275; /note="K->A: Reduces affinity for substrate 20-fold, and decreases affinity for the competitive inhibitor fructose 2,6-bisphosphate 500-fold."; /evidence="ECO:0000269|PubMed:1313010
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
uniprot
proteins
protein_family
FBPase class 1 family
uniprot
proteins
pubmed
1313010
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1846613
uniprot
proteins
pubmed
19651254
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2847161
uniprot
proteins
pubmed
6305949
uniprot
proteins
pubmed
7589895
uniprot
proteins
sequence_length
363
uniprot
proteins