Ormdl3
entrez
66612
canonical
uniprot
Q9CPZ6
canonical
ensembl
ENSMUSG00000038150
resolver
ensp
ENSMUSP00000053056
resolver
enst
ENSMUST00000052919
resolver
genesymbol
Ormdl3
resolver
uniprot
A2A4X7
resolver
uniprot
Q8BN65
resolver
uniprot
Q8R0U5
resolver
uniprot_entry
ORML3_MOUSE
resolver
uniprot_sec
A2A4X7
resolver
uniprot_sec
Q8BN65
resolver
uniprot_sec
Q8R0U5
resolver
amino_acid_sequence
MNVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHVVLLSIPFVSVPVVWTLTNLIHNLGMYIFLHTVKGTPFETPDQGKARLLTHWEQMDYGVQFTASRKFLTITPIVLYFLTSFYTKYDQVHFILNTVSLMTVLIPKLPQLHGVRIFGINKY
uniprot
proteins
function
FUNCTION: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:30700557, PubMed:31880535). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity). {ECO:0000250|UniProtKB:Q8N138, ECO:0000269|PubMed:30700557, ECO:0000269|PubMed:31880535}.
uniprot
proteins
mass_dalton
17477
uniprot
proteins
post_translational_modification
PTM: When hydroxylated at Pro-137, ubiquitinated via 'Lys-48'-linkage, leading to proteasomal degradation. In endothelial cells, ORMDL3 proteasomal degradation is controlled by the sphingosine 1-phosphate receptor signaling pathway. {ECO:0000250|UniProtKB:Q8N138}.
uniprot
proteins
protein_family
ORM family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
30700557
uniprot
proteins
pubmed
31880535
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8N138}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N138}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q8N138, ECO:0000255"; TRANSMEM 43..63; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q8N138, ECO:0000255"; TRANSMEM 95..117; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q8N138, ECO:0000255"; TRANSMEM 122..142; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q8N138, ECO:0000255
uniprot
proteins