Rita1
entrez
100764
canonical
uniprot
Q9D1H0
canonical
ensembl
ENSMUSG00000029600
resolver
ensp
ENSMUSP00000031599
resolver
ensp
ENSMUSP00000136946
resolver
enst
ENSMUST00000031599
resolver
enst
ENSMUST00000177800
resolver
genesymbol
Rita1
resolver
genesymbol_syn
Rita
resolver
uniprot_entry
RITA1_MOUSE
resolver
amino_acid_sequence
MKALHLQHRSPTSYRVKARASYVDETLFGSPARTRPAQPDFDPPWVQNCNRSRGVGPGPPKGSLAKRDCESPSSRGSTPNLTPRKKNKYRLIGHAPSYCDESLFGTSKEGSRMAVGDAAKLRTLFWTPPATPRGSHTPCPRETPLRAIHPAGPSRTEPRVTAGSQMSSQDGLCVPCSLGQRRSHSLTHLTVPSTGHPASSAPQTNGPWSPRPNTSGATVQSPLVTSKACSGRVSGPAPPRRGACPPKPKPPWK
uniprot
proteins
function
FUNCTION: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
27071
uniprot
proteins
protein_family
RITA family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
253
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear (By similarity). {ECO:0000250}.
uniprot
proteins