HRH2
entrez
3274
canonical
uniprot
P25021
canonical
ensembl
ENSG00000113749
resolver
ensp
ENSP00000366506
resolver
ensp
ENSP00000489742
resolver
ensp
ENSP00000602248
resolver
ensp
ENSP00000602249
resolver
ensp
ENSP00000625870
resolver
enst
ENST00000636584
resolver
enst
ENST00000932189
resolver
enst
ENST00000932190
resolver
enst
ENST00000955811
resolver
genesymbol
HRH2
resolver
hgnc
HGNC:5183
resolver
uniprot
A0A1B0GTK7
resolver
uniprot
B5BUP7
resolver
uniprot
Q14464
resolver
uniprot
Q7Z5R9
resolver
uniprot_entry
A0A1B0GTK7_HUMAN
resolver
uniprot_entry
HRH2_HUMAN
resolver
uniprot_sec
B5BUP7
resolver
uniprot_sec
Q14464
resolver
uniprot_sec
Q7Z5R9
resolver
amino_acid_sequence
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for histamine, primarily mediating gastric acid secretion. Predominantly expressed in the gastric mucosa, couples to G(s) G alpha proteins upon histamine binding, leading to activation of adenylate cyclase and increased intracellular cyclic AMP (cAMP) levels (PubMed:38647423, PubMed:39333117). This signaling cascade stimulates parietal cells to secrete hydrochloric acid, playing a key role in digestive physiology. Also expressed in other tissues, including the heart and central nervous system, where it may contribute to cardiac stimulation and modulate neurotransmitter release (By similarity). {ECO:0000250|UniProtKB:P97292, ECO:0000269|PubMed:38647423, ECO:0000269|PubMed:39333117}.
uniprot
proteins
mass_dalton
40098
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10371214
uniprot
proteins
pubmed
15014171
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1714721
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
38418462
uniprot
proteins
pubmed
38647423
uniprot
proteins
pubmed
39333117
uniprot
proteins
pubmed
7755641
uniprot
proteins
pubmed
8817552
uniprot
proteins
pubmed
9374694
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 21..44; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:38418462"; TRANSMEM 54..75; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:38418462"; TRANSMEM 92..114; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:38418462"; TRANSMEM 134..156; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:38418462"; TRANSMEM 175..202; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:38418462"; TRANSMEM 233..259; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:38418462"; TRANSMEM 269..291; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:38418462
uniprot
proteins