Lmbrd1
entrez
68421
canonical
uniprot
Q8K0B2
canonical
ensembl
ENSMUSG00000073725
resolver
ensp
ENSMUSP00000092672
resolver
ensp
ENSMUSP00000140783
resolver
ensp
ENSMUSP00000281398
resolver
genesymbol
Lmbrd1
resolver
uniprot
Q3U696
resolver
uniprot
Q8CCL7
resolver
uniprot
Q8R3D6
resolver
uniprot
Q8VH50
resolver
uniprot
Q9CW67
resolver
uniprot_entry
LMBD1_MOUSE
resolver
uniprot_sec
Q3U696
resolver
uniprot_sec
Q8CCL7
resolver
uniprot_sec
Q8R3D6
resolver
uniprot_sec
Q8VH50
resolver
uniprot_sec
Q9CW67
resolver
amino_acid_sequence
MAAAAAELVIGWCIFGLLLLAILAFCWVYVRKYQSQRESEVVSTVTAIFSLAVALITSALLPVDIFLVSYMKNQNGTFKDWADANVTVQIENTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDEDDASKCTQIKTALKYTLGFVVICALLLLVGAFVPLHLPNNNNSTEWEKVKLLFEDLGTGQGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSTAYERLENTEDIEEVEQHIQTIRSKSKDGRPLPARDRRALKQCEERLRTLRKRERHLEFIENSWWTKFCGALRPLKIIWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIIFGTNLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIESNITSDAHKGNSTLAVPKRCDADAPKDQCTVTRTYIFLHKFWFFSAAYYFGNWAFLVVFLIGLIVSCCKGKKSVIEGVDEDSDLSDDEPSAYSA
uniprot
proteins
function
FUNCTION: Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (PubMed:24078630). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (PubMed:24078630). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (PubMed:27061115). {ECO:0000250|UniProtKB:Q9NUN5, ECO:0000269|PubMed:24078630, ECO:0000269|PubMed:27061115}.
uniprot
proteins
mass_dalton
61062
uniprot
proteins
mutagenesis
MUTAGEN 229; /note="Y->A: Significantly reduced interaction with adapter protein complex 2 and disruption of its function in clathrin-mediated endocytosis of INSR."; /evidence="ECO:0000269|PubMed:24078630"; MUTAGEN 291; /note="W->A: Significantly reduced interaction with adapter protein complex 2 and disruption of its function in clathrin-mediated endocytosis of INSR."; /evidence="ECO:0000269|PubMed:24078630
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9NUN5}.
uniprot
proteins
protein_family
LIMR family
uniprot
proteins
protein_family
LMBRD1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24078630
uniprot
proteins
pubmed
27061115
uniprot
proteins
sequence_length
537
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NUN5}. Lysosome membrane {ECO:0000250|UniProtKB:Q9NUN5}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:24078630}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:24078630}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 48..68; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 98..118; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 303..323; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 406..426; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 484..504; /note="Helical; Name=9"; /evidence="ECO:0000255
uniprot
proteins