H6pd
entrez
100198
canonical
uniprot
Q8CFX1
canonical
ensembl
ENSMUSG00000028980
resolver
ensp
ENSMUSP00000030830
resolver
ensp
ENSMUSP00000081134
resolver
ensp
ENSMUSP00000171314
resolver
ensp
ENSMUSP00000171315
resolver
enst
ENSMUST00000030830
resolver
enst
ENSMUST00000084117
resolver
genesymbol
H6pd
resolver
uniprot
A2A7A7
resolver
uniprot
A2A7A9
resolver
uniprot
B2KGW7
resolver
uniprot
Q8BLH1
resolver
uniprot_entry
A2A7A7_MOUSE
resolver
uniprot_entry
G6PE_MOUSE
resolver
uniprot_sec
A2A7A9
resolver
uniprot_sec
B2KGW7
resolver
uniprot_sec
Q8BLH1
resolver
amino_acid_sequence
MLLAAMCLALLGCLQAQELKGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGKGHSFSFHGAALTAPQQGQKLMDKVLESLSCPKDLVPSRCDELKGQFLQLSQYRQLKTVEDYQTLNKDIETQVQQDGLWEAGRIFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGVIRDTLQNHLTEILTLVAMELPLNISSSAAVLQHKLWAFQALRGLQKSSAILGQYQAYSGQVRRELQKPDGFQSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNRAYCTQSERHWVPEQSRCLPQQIIFYIGHGELGHPAILVSRNLFKPSLPTQKWKEVQDQPGLRLFGRPLSDYYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLLDSLAFEVPRPYPGGAENGQLLDFEFSGGQLTFSQQQLEVLIPDLGSVPKPSDFQVLGARYRQSPLITAWPEELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGHYSFPWAHTHLWLVDERCVPLSDPDSNFQGLQAHLLQHVRVPYYNIHPMPVHLHQRLCAEEDQGAQTYASEISALVANSSFDLVLLGMGTDGHTASLFPQSPTGLDGDQLVVLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTLVSRVGHEPKKWPISGVVPLSGQLVWYMDYEAFLG
uniprot
proteins
ec_number
1.1.1.363
uniprot
proteins
ec_number
1.1.1.47
uniprot
proteins
ec_number
3.1.1.31
uniprot
proteins
function
FUNCTION: Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes (PubMed:12831846, PubMed:16356929, PubMed:18222920, PubMed:4169027). Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway (PubMed:12831846, PubMed:18222920, PubMed:4169027). In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway (PubMed:12831846). May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate (PubMed:12831846). The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum (PubMed:12831846, PubMed:16356929, PubMed:17656460, PubMed:18222920). By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity (PubMed:16356929). {ECO:0000269|PubMed:12831846, ECO:0000269|PubMed:16356929, ECO:0000269|PubMed:17656460, ECO:0000269|PubMed:18222920, ECO:0000269|PubMed:4169027}.
uniprot
proteins
mass_dalton
88928
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage). {ECO:0000269|PubMed:12831846, ECO:0000269|PubMed:4169027}.; PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. {ECO:0000269|PubMed:12831846}.
uniprot
proteins
protein_family
6-phosphogluconolactonase subfamily
uniprot
proteins
protein_family
Glucose-6-phosphate dehydrogenase family; Glucosamine/galactosamine-6-phosphate isomerase family
uniprot
proteins
pubmed
12831846
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16356929
uniprot
proteins
pubmed
17656460
uniprot
proteins
pubmed
18218694
uniprot
proteins
pubmed
18222920
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
4169027
uniprot
proteins
sequence_length
789
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000305|PubMed:12831846}.
uniprot
proteins