Rufy3
entrez
360921
canonical
uniprot
Q5FVJ0
canonical
ensembl
ENSRNOG00000003428
resolver
ensp
ENSRNOP00000093326
resolver
ensp
ENSRNOP00000096851
resolver
enst
ENSRNOT00000100042
resolver
genesymbol
Rufy3
resolver
genesymbol_syn
Ripx
resolver
uniprot
A0A8I6AK59
resolver
uniprot
A5HLX7
resolver
uniprot
A5JUR6
resolver
uniprot_entry
A0A8I6AK59_RAT
resolver
uniprot_entry
RUFY3_RAT
resolver
uniprot_sec
A5HLX7
resolver
uniprot_sec
A5JUR6
resolver
amino_acid_sequence
MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEANALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGSEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYLLESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELELQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPKHH
uniprot
proteins
function
FUNCTION: ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma (By similarity). Plays a role in the generation of neuronal polarity formation and axon growth (PubMed:17439943). Implicated in the formation of a single axon by developing neurons (PubMed:17439943). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (PubMed:17439943). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (By similarity). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). {ECO:0000250|UniProtKB:Q7L099, ECO:0000250|UniProtKB:Q9D394, ECO:0000269|PubMed:17439943}.
uniprot
proteins
mass_dalton
52907
uniprot
proteins
post_translational_modification
PTM: Isoform 1 is partially phosphorylated (PubMed:17439943). Phosphorylated by PAK1 (By similarity). {ECO:0000250|UniProtKB:Q7L099, ECO:0000269|PubMed:17439943}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17439943
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7L099}. Endomembrane system {ECO:0000250|UniProtKB:Q7L099}. Cell projection, invadopodium {ECO:0000250|UniProtKB:Q7L099}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9D394}. Perikaryon {ECO:0000269|PubMed:17439943}. Cell projection {ECO:0000269|PubMed:17439943}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9D394}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9D394}. Lysosome {ECO:0000250|UniProtKB:Q7L099}. Note=Colocalizes with PAK1, F-actin, myosins and integrins in invadopodia at the cell periphery (By similarity). Colocalizes with Ras-related Rab-5 proteins in cytoplasmic vesicles (By similarity). Accumulates in axon growth cones in a F-actin-dependent manner (By similarity). Colocalizes with FSCN1 and F-actin at filipodia and lamellipodia of axonal growth cones (By similarity). Localized in F-actin-enriched filopodia and lamellipodia at axonal growth cones (PubMed:17439943). Colocalizes with DBN1 and F-actin at transitional domain of the axonal growth cone (By similarity). Recruitment to endolysosomes partially depends upon the presence of ARL8 (By similarity). {ECO:0000250|UniProtKB:Q7L099, ECO:0000250|UniProtKB:Q9D394, ECO:0000269|PubMed:17439943}.
uniprot
proteins