Mocs2
entrez
294753
canonical
uniprot
Q6AY59
canonical
ensembl
ENSRNOG00000056325
resolver
ensembl
ENSRNOG00055006374
resolver
ensembl
ENSRNOG00060013938
resolver
ensembl
ENSRNOG00065020350
resolver
ensp
ENSRNOP00000073722
resolver
ensp
ENSRNOP00055008039
resolver
ensp
ENSRNOP00060018952
resolver
ensp
ENSRNOP00065027530
resolver
enst
ENSRNOT00000082990
resolver
enst
ENSRNOT00055010361
resolver
enst
ENSRNOT00060023822
resolver
enst
ENSRNOT00065034377
resolver
genesymbol
Mocs2
resolver
uniprot_entry
MOC2B_RAT
resolver
amino_acid_sequence
MSSLEINNSCFSLETKLPSSHQSVEDSASEPSGYEAKDPPQDTLKDVDDVLEKPKDIIQFTAKKLSVGEVSQLVVSPLCGAVSLFVGTTRNNFEGKKVISLEYEAYLPMAENEIRKICNDIRQKWPVRHIAVFHRLGLVPVSEASTVIAVSSAHRAASLEAVSYAIDSLKAKVPIWKKEIYEESTSSWKRNKECFWAADD
uniprot
proteins
ec_number
2.8.1.12
uniprot
proteins
function
FUNCTION: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group (By similarity). Together with MBIP, inhibits the activity of stress kinase EIF2AK2/PKR; this may suppress JNK activation and subsequent stress-responsive transcription, or suppress eIF2a phosphorylation to favor translation (By similarity). {ECO:0000250|UniProtKB:O96007, ECO:0000255|HAMAP-Rule:MF_03052}.
uniprot
proteins
mass_dalton
22233
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03052}.
uniprot
proteins
protein_family
MOCS2B subfamily
uniprot
proteins
protein_family
MoaE family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
200
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O96007, ECO:0000255|HAMAP-Rule:MF_03052}. Nucleus {ECO:0000250|UniProtKB:O96007}.
uniprot
proteins