GPR55
entrez
9290
canonical
uniprot
Q9Y2T6
canonical
ensembl
ENSG00000135898
resolver
ensp
ENSP00000375893
resolver
ensp
ENSP00000375894
resolver
ensp
ENSP00000410267
resolver
ensp
ENSP00000482381
resolver
ensp
ENSP00000498258
resolver
ensp
ENSP00000556204
resolver
ensp
ENSP00000556205
resolver
enst
ENST00000392039
resolver
enst
ENST00000392040
resolver
enst
ENST00000444078
resolver
enst
ENST00000622008
resolver
enst
ENST00000650999
resolver
enst
ENST00000886145
resolver
enst
ENST00000886146
resolver
genesymbol
GPR55
resolver
hgnc
HGNC:4511
resolver
uniprot
A0A024R484
resolver
uniprot
A8K858
resolver
uniprot
Q8N580
resolver
uniprot_entry
A8K858_HUMAN
resolver
uniprot_entry
GPR55_HUMAN
resolver
uniprot_sec
A0A024R484
resolver
uniprot_sec
Q8N580
resolver
amino_acid_sequence
MSQQNTSGDCLFDGVNELMKTLQFAVHIPTFVLGLLLNLLAIHGFSTFLKNRWPDYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFRMNIRAHRPSRVQLVLQDTTISRG
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (PubMed:36142844, PubMed:36523570, PubMed:37544935). Induces the Ca(2+) release from intracellular stores via ERK, the heterotrimeric G protein GNA13 and RHOA leading to morphological changes including cell rounding and stress fiber formation (PubMed:36142844). In macrophages, acts downstream of lysophosphatidylglucoside to inhibit the translocation of the phospholipid-transporting ABCA1 to plasma membrane and subsequent cholesterol efflux leading to lipid accumulation and foam cell formation (PubMed:37544935). {ECO:0000269|PubMed:19805329, ECO:0000269|PubMed:36142844, ECO:0000269|PubMed:36523570, ECO:0000269|PubMed:37544935}.
uniprot
proteins
mass_dalton
36637
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17765871
uniprot
proteins
pubmed
18757503
uniprot
proteins
pubmed
19723626
uniprot
proteins
pubmed
19805329
uniprot
proteins
pubmed
36142844
uniprot
proteins
pubmed
36523570
uniprot
proteins
pubmed
37544935
uniprot
proteins
pubmed
9931487
uniprot
proteins
sequence_length
319
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18757503}; Multi-pass membrane protein {ECO:0000269|PubMed:18757503}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 59..79; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 95..115; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 138..158; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 181..201; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 272..292; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins