L0R8F8
uniprot
L0R8F8
canonical
amino_acid_sequence
MAPWSREAVLSLYRALLRQGRQLRYTDRDFYFASIRREFRKNQKLEDAEARERQLEKGLVFLNGKLGRII
uniprot
proteins
function
FUNCTION: Assembly factor involved in the biogenesis of the mitochondrial-specific ribosomes (mitoribosomes) (PubMed:28892042, PubMed:30215512, PubMed:31666358). Specifically associates with intermediates of the mitochondrial ribosome large subunit (mt-LSU) and is required for proper ribosome assembly, possibly preventing premature association of the large and small ribosomal subunits (PubMed:28892042, PubMed:30215512, PubMed:31666358). Thereby, indirectly regulates mitochondrial translation (PubMed:28892042, PubMed:30215512, PubMed:31666358). It is also required for complete assembly of the mitochondrial respiratory chain complex I (PubMed:31666358). May also function in DNM1L-mediated mitochondrial fission (PubMed:29083303). {ECO:0000269|PubMed:28892042, ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:30215512, ECO:0000269|PubMed:31666358}.
uniprot
proteins
mass_dalton
8445
uniprot
proteins
mutagenesis
MUTAGEN 12..14; /note="LYR->AAA: Decreased function in mitochondrial fission. Unable to convert the mitochondrial morphology from tubular to fragmented. Abolishes interaction with NDUFAB1; when associated with A-39."; /evidence="ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:30215512"; MUTAGEN 39; /note="F->A: Abolishes interaction with NDUFAB1; when associated with 12-A--A-14."; /evidence="ECO:0000269|PubMed:30215512
uniprot
proteins
protein_family
Complex I LYR family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
21508961
uniprot
proteins
pubmed
23950983
uniprot
proteins
pubmed
25621764
uniprot
proteins
pubmed
28892042
uniprot
proteins
pubmed
29083303
uniprot
proteins
pubmed
30215512
uniprot
proteins
pubmed
31666358
uniprot
proteins
pubmed
35177605
uniprot
proteins
sequence_length
70
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:28892042, ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:30215512}.
uniprot
proteins