Cdc25b
entrez
12531
canonical
uniprot
P30306
canonical
ensembl
ENSMUSG00000027330
resolver
ensp
ENSMUSP00000028804
resolver
ensp
ENSMUSP00000078784
resolver
enst
ENSMUST00000028804
resolver
enst
ENSMUST00000079857
resolver
genesymbol
Cdc25b
resolver
genesymbol_syn
Cdc25m2
resolver
uniprot
F6TGC7
resolver
uniprot
Q3U535
resolver
uniprot
Q99LP3
resolver
uniprot
Q9DBN8
resolver
uniprot_entry
F6TGC7_MOUSE
resolver
uniprot_entry
MPIP2_MOUSE
resolver
uniprot_entry
Q3U535_MOUSE
resolver
uniprot_entry
Q9DBN8_MOUSE
resolver
uniprot_sec
Q99LP3
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by B-type cyclins. {ECO:0000250|UniProtKB:P30305}.
uniprot
proteins
amino_acid_sequence
MEVPLQKSAPGSALSPARVLGGIQRPRHLSVFEFESDGFLGSPEPTASSSPVTTLTQTMHNLAGLGSEPPKAQVGSLSFQNRLADLSLSRRTSECSLSSESSESSDAGLCMDSPSPVDPQMAERTFEQAIQAASRVIQNEQFTIKRFRSLPVRLLEHSPVLQSITNSRALDSWRKTEAGYRAAANSPGEDKENDGYIFKMPQELPHSSSAQALAEWVSRRQAFTQRPSSAPDLMCLTTEWKMEVEELSPVAQSSSLTPVERASEEDDGFVDILESDLKDDEKVPAGMENLISAPLVKKLDKEEEQDLIMFSKCQRLFRSPSMPCSVIRPILKRLERPQDRDVPVQSKRRKSVTPLEEQQLEEPKARVFRSKSLCHEIENILDSDHRGLIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVEKFVIVDCRYPYEYEGGHIKNAVNLPLERDAETFLLQRPIMPCSLDKRIILIFHCEFSSERGPRMCRFIRERDRAANDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFRDELRNFRLKTRSWAGERSRRELCSRLQDQ
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. The three isoforms seem to have a different level of activity. {ECO:0000250|UniProtKB:P30305}.
uniprot
proteins
mass_dalton
65490
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-351 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-167 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-321 and Ser-372 by MAPK14 is required for binding to 14-3-3 proteins (By similarity). {ECO:0000250|UniProtKB:P30305}.
uniprot
proteins
protein_family
MPI phosphatase family
uniprot
proteins
pubmed
1313771
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
576
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P30305}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P30305}.
uniprot
proteins