AKAP4
entrez
8852
canonical
uniprot
Q5JQC9
canonical
ensembl
ENSG00000147081
resolver
ensp
ENSP00000351327
resolver
ensp
ENSP00000365232
resolver
genesymbol
AKAP4
resolver
genesymbol_syn
AKAP82
resolver
hgnc
HGNC:374
resolver
uniprot
A0A384MQY7
resolver
uniprot
A0AV85
resolver
uniprot
O60904
resolver
uniprot
O95246
resolver
uniprot
Q5JQD1
resolver
uniprot
Q5JQD2
resolver
uniprot
Q5JQD3
resolver
uniprot_entry
A0A384MQY7_HUMAN
resolver
uniprot_entry
AKAP4_HUMAN
resolver
uniprot_sec
A0AV85
resolver
uniprot_sec
O60904
resolver
uniprot_sec
O95246
resolver
uniprot_sec
Q5JQD1
resolver
uniprot_sec
Q5JQD2
resolver
uniprot_sec
Q5JQD3
resolver
amino_acid_sequence
MMAYSDTTMMSDDIDWLRSHRGVCKVDLYNPEGQQDQDRKVICFVDVSTLNVEDKDYKDAASSSSEGNLNLGSLEEKEIIVIKDTEKKDQSKTEGSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPSTSTCKHKVGDTEGEYHRASSENCYSVYADQVNIDYLMNRPQNLRLEMTAAKNTNNNQSPSAPPAKPPSTQRAVISPDGECSIDDLSFYVNRLSSLVIQMAHKEIKEKLEGKSKCLHHSICPSPGNKERISPRTPASKIASEMAYEAVELTAAEMRGTGEESREGGQKSFLYSELSNKSKSGDKQMSQRESKEFADSISKGLMVYANQVASDMMVSLMKTLKVHSSGKPIPASVVLKRVLLRHTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNQWKQNATDIMEAMLKRLVSALIGEEKETKSQSLSYASLKAGSHDPKCRNQSLEFSTMKAEMKERDKGKMKSDPCKSLTSAEKVGEHILKEGLTIWNQKQGNSCKVATKACSNKDEKGEKINASTDSLAKDLIVSALKLIQYHLTQQTKGKDTCEEDCPGSTMGYMAQSTQYEKCGGGQSAKALSVKQLESHRAPGPSTCQKENQHLDSQKMDMSNIVLMLIQKLLNENPFKCEDPCEGENKCSEPRASKAASMSNRSDKAEEQCQEHQELDCTSGMKQANGQFIDKLVESVMKLCLIMAKYSNDGAALAELEEQAASANKPNFRGTRCIHSGAMPQNYQDSLGHEVIVNNQCSTNSLQKQLQAVLQWIAASQFNVPMLYFMGDKDGQLEKLPQVSAKAAEKGYSVGGLLQEVMKFAKERQPDEAVGKVARKQLLDWLLANL
uniprot
proteins
disease_involvement
DISEASE: Note=Spermatogenic failure (PubMed:34415320, PubMed:38050179). A male infertility disorder caused by spermatogenesis defects that result in non-obstructive azoospermia (PubMed:34415320, PubMed:38050179). The disease is caused by variants affecting the gene represented in this entry (PubMed:34415320, PubMed:38050179). {ECO:0000269|PubMed:34415320, ECO:0000269|PubMed:38050179}.
uniprot
proteins
function
FUNCTION: Major structural component of sperm fibrous sheath (PubMed:9822690). Plays a role in sperm motility (PubMed:34415320, PubMed:9822690). {ECO:0000269|PubMed:34415320, ECO:0000269|PubMed:9822690}.
uniprot
proteins
mass_dalton
94477
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by STK33 during sperm flagella assembly. {ECO:0000250|UniProtKB:Q60662}.
uniprot
proteins
protein_family
AKAP110 family
uniprot
proteins
pubmed
12509440
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
31429579
uniprot
proteins
pubmed
34415320
uniprot
proteins
pubmed
38050179
uniprot
proteins
pubmed
9514854
uniprot
proteins
pubmed
9822690
uniprot
proteins
sequence_length
854
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000269|PubMed:31429579, ECO:0000269|PubMed:34415320, ECO:0000269|PubMed:9822690}. Note=Localizes to the principle piece of the sperm flagellum. {ECO:0000269|PubMed:9822690}.
uniprot
proteins