Cirbp
entrez
81825
canonical
uniprot
P60825
canonical
ensembl
ENSRNOG00000088478
resolver
ensembl
ENSRNOG00055032680
resolver
ensembl
ENSRNOG00060031652
resolver
ensembl
ENSRNOG00065019406
resolver
ensp
ENSRNOP00055046570
resolver
ensp
ENSRNOP00060045344
resolver
ensp
ENSRNOP00065026101
resolver
enst
ENSRNOT00055056464
resolver
enst
ENSRNOT00060054846
resolver
enst
ENSRNOT00065032676
resolver
genesymbol
Cirbp
resolver
genesymbol_syn
Cirp
resolver
uniprot
O09069
resolver
uniprot
O09148
resolver
uniprot
Q61413
resolver
uniprot
Q6NT88
resolver
uniprot_entry
CIRBP_RAT
resolver
uniprot_entry
Q6NT88_RAT
resolver
uniprot_sec
O09069
resolver
uniprot_sec
O09148
resolver
uniprot_sec
Q61413
resolver
amino_acid_sequence
MASDEGKLFVGGLSFDTNEQALEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRSRGRGFSRGGGDRGYGGGRFESRSGGYGGSRDYYASRSQGGSYGYRSSGGSYRDSYDSYATHNE
uniprot
proteins
function
FUNCTION: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
18607
uniprot
proteins
post_translational_modification
PTM: Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity). {ECO:0000250}.; PTM: Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation (By similarity). {ECO:0000250}.
uniprot
proteins
sequence_length
172
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity). {ECO:0000250}.
uniprot
proteins