Hexa
entrez
300757
canonical
uniprot
Q641X3
canonical
ensembl
ENSRNOG00000010252
resolver
ensembl
ENSRNOG00055027102
resolver
ensembl
ENSRNOG00060016046
resolver
ensembl
ENSRNOG00065007034
resolver
ensp
ENSRNOP00000013747
resolver
ensp
ENSRNOP00055038495
resolver
ensp
ENSRNOP00060022084
resolver
ensp
ENSRNOP00065008066
resolver
enst
ENSRNOT00055046863
resolver
enst
ENSRNOT00060027496
resolver
enst
ENSRNOT00065010982
resolver
genesymbol
Hexa
resolver
uniprot_entry
HEXA_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Addition of GM2A stimulates the hydrolysis of sulfated glycosphingolipid SM2 and the ganglioside GM2. {ECO:0000250|UniProtKB:P06865}.
uniprot
proteins
amino_acid_sequence
MAGCRLWVSLLLAAALACLATALWPWPQYIQTSHRRYTLYPNNFQFRYHAGSAAQAGCVVLDEAFRRYRSLLFGSGSWPRPSFSKKQQPLGKNILMVSVVTAECNEFPNLESVENYTLTINDDQCLLSSETVWGALRGLETFSQLVWKSAEGTFFINKTKITDFPRFPHRGILLDTSRHYLPLSSILNTLDVMAYNKFNVFHWHLVDDSSFPYESFTFPELTRKGSFNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGAGVPGLLTPCYSGSRLSGTYGPVNPSLNSTYDFMSTFFLEISSVFPDFYLHLGGDEVDFTCWKSNPNIQAFMKKKGFTDYKQLESFYIQTLLDIVSDYDKGYVVWQEVFDNKVKVRPDTIIQVWREEMPVQYMKEIEAITQAGFRALLSAPWYLNRVKYGPDWKEMYKVEPLAFRGTPAQKALVIGGEACMWGEYVDSTNLVPRLWPRAGAIAERLWSSNLTTNMDFAFKRLSHFRCELLRRGIQAQPISVGYCEQEFEHT
uniprot
proteins
ec_number
3.2.1.52
uniprot
proteins
function
FUNCTION: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. {ECO:0000250|UniProtKB:P06865}.
uniprot
proteins
mass_dalton
60538
uniprot
proteins
protein_family
Glycosyl hydrolase 20 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
528
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250}.
uniprot
proteins