Comt
entrez
12846
canonical
uniprot
O88587
canonical
ensembl
ENSMUSG00000000326
resolver
ensp
ENSMUSP00000000335
resolver
ensp
ENSMUSP00000111272
resolver
ensp
ENSMUSP00000130077
resolver
genesymbol
Comt
resolver
genesymbol_syn
Comt1
resolver
uniprot
Q91XH4
resolver
uniprot_entry
COMT_MOUSE
resolver
uniprot_sec
Q91XH4
resolver
amino_acid_sequence
MLLAAVSLGLLLLAFLLLLRHLGWGLVAIGWFEFVQQPVHNLLMGGTKEQRILRHVQQHAKPGDPQSVLEAIDTYCSEKEWAMNVGDAKGQIMDAVIREYRPSLVLELGAYCGYSAVRMARLLPPGARLLTMEINPDYAAITQQMLDFAGLQDKVSILIGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAVYQGPGSSPVKS
uniprot
proteins
ec_number
2.1.1.6
uniprot
proteins
function
FUNCTION: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. {ECO:0000269|PubMed:18794526}.
uniprot
proteins
mass_dalton
29486
uniprot
proteins
mutagenesis
MUTAGEN 51; /note="R->L: Reduces methyltransferase activity against norepinephrine."; /evidence="ECO:0000269|PubMed:18794526
uniprot
proteins
protein_family
Cation-dependent O-methyltransferase family
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18794526
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9707588
uniprot
proteins
sequence_length
265
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Soluble]: Cytoplasm {ECO:0000250|UniProtKB:P22734}.; SUBCELLULAR LOCATION: [Isoform Membrane-bound]: Cell membrane {ECO:0000250|UniProtKB:P22734}; Single-pass type II membrane protein {ECO:0000255}; Extracellular side {ECO:0000250|UniProtKB:P22734}.
uniprot
proteins
transmembrane_region
TRANSMEM 3..19; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins