Hax1
entrez
291202
canonical
uniprot
Q7TSE9
canonical
ensembl
ENSRNOG00000045647
resolver
ensembl
ENSRNOG00055021629
resolver
ensembl
ENSRNOG00060028248
resolver
ensembl
ENSRNOG00065028381
resolver
ensp
ENSRNOP00000064877
resolver
ensp
ENSRNOP00000067159
resolver
genesymbol
Hax1
resolver
genesymbol_syn
Hs1bp1
resolver
uniprot
Q5D1N3
resolver
uniprot
Q5D1N4
resolver
uniprot
Q7TSE7
resolver
uniprot
Q7TSE8
resolver
uniprot_entry
HAX1_RAT
resolver
uniprot_sec
Q5D1N3
resolver
uniprot_sec
Q5D1N4
resolver
uniprot_sec
Q7TSE7
resolver
uniprot_sec
Q7TSE8
resolver
amino_acid_sequence
MSVFDLFRGFFGFPGPRSHRDPFFGGMTRDDDDDEDDEEEEDSGAWGRESYAFDGFHPTEEFGFSFSPRGGMRFHGNFGFDDLVRDFNSIFSEMGAWTLPSHSPELPGPESETPGVRLREGQTLRDSMLKYPDSHQPRIFEGVLESHAKPESSKPAPDWGSQGPFHRLDDTWPVSPHSRAREDKDLDSQVSQEGLGPLLQPQPKSYFKSISVTKITKPDGTVEEHRTVVDSEGRRETTVTHQEAHDSSRSDPDPPRSSALDDPFSILDLLLGRWFRSR
uniprot
proteins
function
FUNCTION: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. {ECO:0000250|UniProtKB:O00165, ECO:0000269|PubMed:15159385, ECO:0000269|PubMed:19913549}.
uniprot
proteins
mass_dalton
31448
uniprot
proteins
protein_family
HAX1 family
uniprot
proteins
pubmed
15159385
uniprot
proteins
pubmed
16516414
uniprot
proteins
pubmed
19913549
uniprot
proteins
pubmed
23164465
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:19913549}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O00165}. Nucleus membrane {ECO:0000250|UniProtKB:O00165}. Cytoplasmic vesicle {ECO:0000269|PubMed:15159385}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:O00165}. Cell membrane {ECO:0000250|UniProtKB:O00165}; Peripheral membrane protein {ECO:0000250|UniProtKB:O00165}; Cytoplasmic side {ECO:0000250|UniProtKB:O00165}. Sarcoplasmic reticulum {ECO:0000269|PubMed:19913549}. Cytoplasm, P-body {ECO:0000250|UniProtKB:O00165}. Cytoplasm {ECO:0000269|PubMed:23164465}. Nucleus {ECO:0000250|UniProtKB:O00165}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:23164465}. Nucleus {ECO:0000250|UniProtKB:O00165}. Note=Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited, and in response to cellular stress caused by arsenite (in vitro). {ECO:0000250|UniProtKB:O00165}.
uniprot
proteins