KCTD11
entrez
147040
canonical
uniprot
Q693B1
canonical
ensembl
ENSG00000213859
resolver
ensembl
ENSG00000288399
resolver
ensp
ENSP00000328352
resolver
ensp
ENSP00000495203
resolver
genesymbol
KCTD11
resolver
genesymbol_syn
C17orf36
resolver
genesymbol_syn
REN
resolver
hgnc
HGNC:21302
resolver
uniprot
A0A158RFT7
resolver
uniprot
B3KPE0
resolver
uniprot_entry
A0A158RFT7_HUMAN
resolver
uniprot_entry
KCD11_HUMAN
resolver
uniprot_sec
B3KPE0
resolver
amino_acid_sequence
MLGAMFRAGTPMPPNLNSQGGGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALLRAEADFYQIRPLLDALRELEASQGTPAPTAALLHADVDVSPRLVHFSARRGPHHYELSSVQVDTFRANLFCTDSECLGALRARFGVASGDRAEGSPHFHLEWAPRPVELPEVEYGRLGLQPLWTGGPGERREVVGTPSFLEEVLRVALEHGFRLDSVFPDPEDLLNSRSLRFVRH
uniprot
proteins
function
FUNCTION: Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. {ECO:0000269|PubMed:15249678, ECO:0000269|PubMed:20081843, ECO:0000269|PubMed:21237243}.
uniprot
proteins
mass_dalton
25887
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15249678
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20081843
uniprot
proteins
pubmed
21237243
uniprot
proteins
pubmed
21472142
uniprot
proteins
pubmed
25974686
uniprot
proteins
pubmed
27152988
uniprot
proteins
sequence_length
232
uniprot
proteins