Adra2a
entrez
11551
canonical
uniprot
Q01338
canonical
ensembl
ENSMUSG00000033717
resolver
ensp
ENSMUSP00000036203
resolver
ensp
ENSMUSP00000157421
resolver
enst
ENSMUST00000036700
resolver
enst
ENSMUST00000237285
resolver
genesymbol
Adra2a
resolver
uniprot
Q3URE6
resolver
uniprot_entry
ADA2A_MOUSE
resolver
uniprot_sec
Q3URE6
resolver
amino_acid_sequence
MFRQEQPLAEGSFAPMGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGPTGAEAEPLPTQLNGAPGEPAPAGPRDGDALDLEESSSSEHAERPPGPRRPDRGPRAKGKTRASQVKPGDSLPRRGPGAAGPGASGSGHGEERGGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPSQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
uniprot
proteins
function
FUNCTION: Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity (PubMed:10647009). {ECO:0000250|UniProtKB:P08913, ECO:0000269|PubMed:10647009}.
uniprot
proteins
mass_dalton
50555
uniprot
proteins
protein_family
ADRA2A sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10647009
uniprot
proteins
pubmed
1353249
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08913}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08913}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..71; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P08913"; TRANSMEM 86..107; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P08913"; TRANSMEM 121..144; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P08913"; TRANSMEM 168..181; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P08913"; TRANSMEM 209..232; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P08913"; TRANSMEM 389..413; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P08913"; TRANSMEM 422..443; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P08913
uniprot
proteins