Slc10a1
entrez
24777
canonical
uniprot
P26435
canonical
ensembl
ENSRNOG00000005794
resolver
ensembl
ENSRNOG00055020271
resolver
ensembl
ENSRNOG00060029184
resolver
ensembl
ENSRNOG00065017546
resolver
ensp
ENSRNOP00000007825
resolver
ensp
ENSRNOP00055028048
resolver
ensp
ENSRNOP00060042160
resolver
ensp
ENSRNOP00065023298
resolver
enst
ENSRNOT00000007825
resolver
enst
ENSRNOT00055034621
resolver
enst
ENSRNOT00060050677
resolver
enst
ENSRNOT00065029352
resolver
genesymbol
Slc10a1
resolver
genesymbol_syn
Ntcp
resolver
uniprot
Q5BK99
resolver
uniprot_entry
NTCP_RAT
resolver
uniprot_sec
Q5BK99
resolver
activity_regulation
ACTIVITY REGULATION: The transport of bile acids is sodium-dependent. {ECO:0000250|UniProtKB:Q14973}.
uniprot
proteins
amino_acid_sequence
MEVHNVSAPFNFSLPPGFGHRATDKALSIILVLMLLLIMLSLGCTMEFSKIKAHLWKPKGVIVALVAQFGIMPLAAFLLGKIFHLSNIEALAILICGCSPGGNLSNLFTLAMKGDMNLSIVMTTCSSFSALGMMPLLLYVYSKGIYDGDLKDKVPYKGIMISLVIVLIPCTIGIVLKSKRPHYVPYILKGGMIITFLLSVAVTALSVINVGNSIMFVMTPHLLATSSLMPFSGFLMGYILSALFQLNPSCRRTISMETGFQNIQLCSTILNVTFPPEVIGPLFFFPLLYMIFQLAEGLLIIIIFRCYEKIKPPKDQTKITYKAAATEDATPAALEKGTHNGNIPPLQPGPSPNGLNSGQMAN
uniprot
proteins
function
FUNCTION: As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins (PubMed:1961729). It is strictly dependent on the extracellular presence of sodium (PubMed:1961729). It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:9486191). Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity). {ECO:0000250|UniProtKB:Q14973, ECO:0000269|PubMed:1961729, ECO:0000269|PubMed:9486191}.
uniprot
proteins
mass_dalton
39295
uniprot
proteins
protein_family
Bile acid:sodium symporter (BASS) (TC 2.A.28) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1961729
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9486191
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q14973}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q14973}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..44; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q14973"; TRANSMEM 48..83; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q14973"; TRANSMEM 87..112; /note="Discontinuously helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q14973"; TRANSMEM 116..142; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q14973"; TRANSMEM 157..179; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q14973"; TRANSMEM 184..217; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q14973"; TRANSMEM 220..243; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q14973"; TRANSMEM 248..273; /note="Discontinuously helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q14973"; TRANSMEM 281..311; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q14973
uniprot
proteins