Otop1
entrez
305427
canonical
uniprot
Q7M734
canonical
ensembl
ENSRNOG00000028423
resolver
ensembl
ENSRNOG00055016058
resolver
ensembl
ENSRNOG00060018892
resolver
ensembl
ENSRNOG00065031401
resolver
ensp
ENSRNOP00000047534
resolver
ensp
ENSRNOP00055021921
resolver
ensp
ENSRNOP00060026642
resolver
ensp
ENSRNOP00065044551
resolver
enst
ENSRNOT00000050367
resolver
enst
ENSRNOT00055027254
resolver
enst
ENSRNOT00060032639
resolver
enst
ENSRNOT00065054128
resolver
genesymbol
Otop1
resolver
uniprot_entry
OTOP1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by both acid and alkali, with proton influx in response to extracellular acid and proton efflux during alkali stimulation. Inhibited by Zn(2+); this inhibition is thought to be pH-sensitive. Currents evoked in response to mild acid (pH 6.0) stimulus may also be mildly potentiated by exposure to Zn(2+). Activated by NH(4)Cl. {ECO:0000250|UniProtKB:Q80VM9}.
uniprot
proteins
amino_acid_sequence
MPGDRGALSSPAASSGSPSAAPSGIAACPPPPSPLARASPQASGPRRGASVPQKLAETLSSQYGLNVFVAGLLFLLAWAVHATGVGKSDLLCVLTALMLLQLLWMLWYVGRSYMQRRLIRPKDTHAGARWLRGSITLFAFITIVLGCLKVAYFIGFSECLSATEGVFPVTHAVHTLLQVYFLWGHAKDIIMSFKTLERFGVIHSVFTNLLLWANSVLNESKHQLNEHKERLITLGFGNITIVLDDHTPQCNCTPPALCSALSHGIYYLYPFNIEYQILASTMLYVLWKNIGRRVDSSRHQKMQCRFDGVLVGSVLGLTVLAATIAVVVVYMIHIGRSKSKSESALIMFYLYAITVLLLMGAAGLVGSWIYRVDEKSLDESKNPARKLDADLLVATASGSWLLSWGSILAIACAETRPPYTWYNLPYSVLVIVEKYVQNIFIIESVHLEPEGVPEDVRTLRVVTVCSGEAAALAASSLGSQGTAQDGSPAVNGNLHLQQRCEKEDQEADWEGATGTTRCLDFLQGGMKRRLLRNITAFLFLCNISLWIPPAFGCRPEYDNGLEEIVFGFEPWIIVVNLAMPFSIFYRMHAAAALFEVYCKI
uniprot
proteins
function
FUNCTION: Proton-selective ion channel. Biphasically modulated by acid and alkali, mediating proton influx and efflux in response to extracellular acid and base stimulation, respectively. Sour taste receptor, which carries inward currents in response to extracellular acidification. Sensor for ammonium chloride (NH(4)Cl) in taste receptor cells. NH(4)Cl acts by increasing the intracellular pH, thereby generating a driving force for proton entry through OTOP1 channel. Might also participate in alkaline sensation. Plays a role in the regulation of Ca(2+) flux in response to purigenic (ATP, ADP and UDP) stimuli, leading to increase in cytosolic Ca(2+) due to influx of extracellular calcium. May play this role by inhibiting P2Y purinoceptor-mediated Ca(2+) release in a Ca(2+)-dependent manner and promote an influx of Ca(2+) in response to ATP. Through this mechanism and possibly others, plays a role in the formation and function of calcium carbonate-based structures in the vestibular system of the inner ear, called otoconia, that sense gravity and linear acceleration. In obesity, may attenuate adipose tissue inflammation, through the negative regulation of IFNG signaling, hence may play an adaptive role in the maintainance of metabolic homeostasis. Following alkali activation, may also be permeable Na(+), K(+), Cs(+) and Li(+). {ECO:0000250|UniProtKB:Q80VM9}.
uniprot
proteins
mass_dalton
65929
uniprot
proteins
protein_family
Otopetrin family
uniprot
proteins
pubmed
12651873
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
600
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q80VM9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7ZWK8}. Cell projection, microvillus {ECO:0000250|UniProtKB:Q80VM9}. Note=Found in the gelatinous membrane overlying the inner ear macular epithelium. Also detected in the apical microvilli in inner ear supporting cells. {ECO:0000250|UniProtKB:Q80VM9}.
uniprot
proteins
transmembrane_region
TRANSMEM 57..78; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q7ZWK8, ECO:0000255"; TRANSMEM 87..110; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q7ZWK8"; TRANSMEM 129..151; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q7ZWK8"; TRANSMEM 162..186; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q7ZWK8"; TRANSMEM 195..221; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q7ZWK8"; TRANSMEM 263..288; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q7ZWK8"; TRANSMEM 310..332; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q7ZWK8"; TRANSMEM 343..368; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q7ZWK8"; TRANSMEM 387..411; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q7ZWK8"; TRANSMEM 422..442; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q7ZWK8"; TRANSMEM 533..551; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q7ZWK8"; TRANSMEM 570..593; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q7ZWK8
uniprot
proteins