Il2
entrez
16183
canonical
uniprot
P04351
canonical
ensembl
ENSMUSG00000027720
resolver
ensp
ENSMUSP00000029275
resolver
enst
ENSMUST00000029275
resolver
genesymbol
Il2
resolver
genesymbol_syn
Il-2
resolver
uniprot
P97945
resolver
uniprot
Q791T3
resolver
uniprot_entry
IL2_MOUSE
resolver
uniprot_sec
P97945
resolver
uniprot_sec
Q791T3
resolver
amino_acid_sequence
MYSMQLASCVTLTLVLLVNSAPTSSSTSSSTAEAQQQQQQQQQQQQHLEQLLMDLQELLSRMENYRNLKLPRMLTFKFYLPKQATELKDLQCLEDELGPLRHVLDLTQSKSFQLEDAENFISNIRVTVVKLKGSDNTFECQFDDESATVVDFLRRWIAFCQSIISTSPQ
uniprot
proteins
function
FUNCTION: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance (PubMed:14614860, PubMed:9814585). Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5 (PubMed:14614860, PubMed:27018889). This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance (PubMed:14614860). Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells (PubMed:9814585). {ECO:0000250|UniProtKB:P60568, ECO:0000269|PubMed:9814585}.
uniprot
proteins
mass_dalton
19400
uniprot
proteins
protein_family
IL-2 family
uniprot
proteins
pubmed
10779485
uniprot
proteins
pubmed
11526406
uniprot
proteins
pubmed
1420317
uniprot
proteins
pubmed
14614860
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
2578624
uniprot
proteins
pubmed
25992858
uniprot
proteins
pubmed
27018889
uniprot
proteins
pubmed
3003564
uniprot
proteins
pubmed
3918306
uniprot
proteins
pubmed
6240025
uniprot
proteins
pubmed
8262055
uniprot
proteins
pubmed
8319981
uniprot
proteins
pubmed
9814585
uniprot
proteins
sequence_length
169
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins