EMC6
entrez
83460
canonical
uniprot
Q9BV81
canonical
ensembl
ENSG00000127774
resolver
ensp
ENSP00000248378
resolver
ensp
ENSP00000380322
resolver
ensp
ENSP00000560822
resolver
ensp
ENSP00000560823
resolver
enst
ENST00000248378
resolver
enst
ENST00000397133
resolver
enst
ENST00000890763
resolver
enst
ENST00000890764
resolver
genesymbol
EMC6
resolver
genesymbol_syn
TMEM93
resolver
hgnc
HGNC:28430
resolver
uniprot_entry
EMC6_HUMAN
resolver
amino_acid_sequence
MAAVVAKREGPPFISEAAVRGNAAVLDYCRTSVSALSGATAGILGLTGLYGFIFYLLASVLLSLLLILKAGRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000305}.
uniprot
proteins
mass_dalton
12017
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="D->A: No effect on EMC assembly but decreased membrane insertion of hydrophobic transmembrane helices-containing proteins by the EMC."; /evidence="ECO:0000269|PubMed:32439656"; MUTAGEN 31; /note="T->A: No effect on EMC assembly but decreased membrane insertion of hydrophobic transmembrane helices-containing proteins by the EMC."; /evidence="ECO:0000269|PubMed:32439656
uniprot
proteins
protein_family
EMC6 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22119785
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
29242231
uniprot
proteins
pubmed
29809151
uniprot
proteins
pubmed
30415835
uniprot
proteins
pubmed
32439656
uniprot
proteins
pubmed
32459176
uniprot
proteins
sequence_length
110
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785, ECO:0000269|PubMed:30415835}; Multi-pass membrane protein {ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..44; /note="Helical"; /evidence="ECO:0000269|PubMed:32439656"; TRANSMEM 51..71; /note="Helical"; /evidence="ECO:0000269|PubMed:32439656"; TRANSMEM 90..106; /note="Helical"; /evidence="ECO:0000269|PubMed:32439656
uniprot
proteins