Prickle3
entrez
54630
canonical
uniprot
Q80VL3
canonical
ensembl
ENSMUSG00000031145
resolver
ensp
ENSMUSP00000033485
resolver
ensp
ENSMUSP00000127892
resolver
enst
ENSMUST00000033485
resolver
enst
ENSMUST00000129662
resolver
genesymbol
Prickle3
resolver
genesymbol_syn
Lmo6
resolver
uniprot
B1AVA9
resolver
uniprot
F6SA42
resolver
uniprot
Q8BNH2
resolver
uniprot
Q8CAY9
resolver
uniprot_entry
F6SA42_MOUSE
resolver
uniprot_entry
PRIC3_MOUSE
resolver
uniprot_entry
Q8BNH2_MOUSE
resolver
uniprot_sec
B1AVA9
resolver
uniprot_sec
Q8CAY9
resolver
amino_acid_sequence
MFARGSRRRRSGRAPPEAEDPARGQPCNSCREQCPGFLLHGWRKICQHCKCPREEHAVRTVPVDLERIMCRLISDFQRHSISDDDSGCASEEYAWVPPGLKPEQVYQFFSCLPEDKVPYVNSPGEKYRIKQLLHQLPPHDSEAQYCTALEEEEKKELRAFSQQRKRENLGRATVRIFPVTITGAICEECGKQIGGGDIAVFASRAGLGACWHPQCFVCTTCQELLVDLIYFYHAGKVYCGRHHAECLRPRCQACDEIIFSPECTEAEGRHWHMGHFCCFECEASLGGQRYVMRQSRPHCCACYEARHAEYCDGCGEHIGLDQGQMAYEGQHWHASDRCFCCSRCSRPLLGRPFLPRRGLIFCSRACSLGSETTAPGPGRRSWSAGTVTTPLTTSTASFSATEGTSETASKGTCTKAEPAAGPEEPSHFLRGAPHRHSMPELGLRSAPEPPTESPGHPAPHPDDNAFGRQSTPRVSFRDPLVSEGGPRRTLSAPPAQRRRPRSPPPRTPSCHHHHHHRRRRQRHRRRGSHHHHHHPGRHGHHRCDLGSGSDSGSCSSSPSSPSSESSEDDGFFLGERIPLPPHLCRPRTTQDTSTETFNSPAQPLVQESHPVMPRQTRDKNCIVA
uniprot
proteins
function
FUNCTION: Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135). {ECO:0000250|UniProtKB:A8WH69, ECO:0000269|PubMed:32516135}.
uniprot
proteins
mass_dalton
69727
uniprot
proteins
protein_family
Prickle / espinas / testin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32516135
uniprot
proteins
sequence_length
624
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A8WH69}. Cell membrane {ECO:0000250|UniProtKB:A8WH69}; Peripheral membrane protein {ECO:0000250|UniProtKB:A8WH69}; Cytoplasmic side {ECO:0000250|UniProtKB:A8WH69}. Mitochondrion {ECO:0000269|PubMed:32516135}. Note=Recruited by VANGL2 to anterior cell borders. This polarity is controlled by Wnt proteins (By similarity). WTIP is involved in the recruitment of PRICKLE3 to the basal body (By similarity). {ECO:0000250|UniProtKB:A8WH69}.
uniprot
proteins