P49801
uniprot
P49801
canonical
amino_acid_sequence
LAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKL
uniprot
proteins
function
FUNCTION: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity. {ECO:0000250|UniProtKB:P49758}.
uniprot
proteins
mass_dalton
7530
uniprot
proteins
pubmed
8548815
uniprot
proteins
sequence_length
66
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P49758}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49758}. Membrane {ECO:0000250|UniProtKB:P49758}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49758}. Nucleus {ECO:0000250|UniProtKB:P49758}. Cell membrane {ECO:0000250|UniProtKB:Q9Z2H2}. Note=Interaction with GNB5 mediates translocation to the nucleus. {ECO:0000250|UniProtKB:P49758}.
uniprot
proteins