Ncoa4
entrez
27057
canonical
uniprot
Q5U4H9
canonical
ensembl
ENSMUSG00000056234
resolver
ensp
ENSMUSP00000107625
resolver
ensp
ENSMUSP00000126071
resolver
ensp
ENSMUSP00000242845
resolver
ensp
ENSMUSP00000242849
resolver
ensp
ENSMUSP00000349411
resolver
enst
ENSMUST00000111994
resolver
enst
ENSMUST00000163336
resolver
genesymbol
Ncoa4
resolver
genesymbol_syn
Rfg
resolver
uniprot
Q3UI10
resolver
uniprot
Q3UJ26
resolver
uniprot
Q3UJ63
resolver
uniprot
Q3UKL9
resolver
uniprot
Q8BSH1
resolver
uniprot
Q9CXF3
resolver
uniprot
Q9WV42
resolver
uniprot_entry
NCOA4_MOUSE
resolver
uniprot_entry
Q8BSH1_MOUSE
resolver
uniprot_entry
Q9CXF3_MOUSE
resolver
uniprot_sec
Q3UI10
resolver
uniprot_sec
Q3UJ26
resolver
uniprot_sec
Q3UJ63
resolver
uniprot_sec
Q3UKL9
resolver
uniprot_sec
Q9WV42
resolver
amino_acid_sequence
MNTSLEQSGCYSNRETLLRCSDARRELELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLNEQVDLIYQLKEETLQQQAQQLYWLMGQFNCLIHQLEYTQNKDLANQVSVCLERLGSLALKPEDSTVLLFEADTSALRQTITTFGSLKTIQIPEHLMAHASSSSIGPFLEKRGYIQVPEQKSASSGTAVSLSEWLLVSKPAIGLQAPYVPSTNPQDWLIPKQTSENSQTSARACSFFSDAWGNLKGLENWLLNSHQQEIAGKPSSSKCNSHCSTSSFSPEAEKAEDVELLDQDELDLSDWLVTPQEPCELEKPVDGSWETSEKFKLLFQVFREPYNVSDWLVKPDSCTNCQGNQPRGVEIENLGNLKCLNDHLEAKKSVSVPGATISDGWLAQNHQDTWKVEEVCKANEPCTSFAECVCDDNCEKEAMYKWLLKKGGKDKNGMPMEPKSEPEKHRESLTLWLCPSRNELTEQAKAPKAMAPARIADSFHVIKNSSLSEWLMGPTCKGGPKDVPNTEERAGKEMLQSSMATSWCPFNTADWVLPGKKVGSLSQFPSGEDKWLLRKKAQEAFLNSPLQEERNFRPDCYGLPAVCDLFACMQLKVDKEKWLYRTPLQM
uniprot
proteins
function
FUNCTION: Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:24695223, PubMed:25327288, PubMed:26776506). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:24695223, PubMed:26776506). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (By similarity). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26776506). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (By similarity). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (By similarity). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (By similarity). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095). {ECO:0000250|UniProtKB:Q13772, ECO:0000269|PubMed:24695223, ECO:0000269|PubMed:24910095, ECO:0000269|PubMed:25327288, ECO:0000269|PubMed:26776506}.
uniprot
proteins
mass_dalton
70381
uniprot
proteins
post_translational_modification
PTM: NCOA4 levels are regulated via HERC2-mediated ubiquitination leading to proteosomal degradation; HERC2 association is dependent on NCOA4 [2Fe-2S] cluster-binding. {ECO:0000250|UniProtKB:Q13772}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24695223
uniprot
proteins
pubmed
24910095
uniprot
proteins
pubmed
25327288
uniprot
proteins
pubmed
26776506
uniprot
proteins
sequence_length
625
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:24695223}. Autolysosome {ECO:0000250|UniProtKB:Q13772}. Nucleus {ECO:0000250|UniProtKB:Q13772}. Chromosome {ECO:0000250|UniProtKB:Q13772}.
uniprot
proteins