Cln5
entrez
211286
canonical
uniprot
Q3UMW8
canonical
ensembl
ENSMUSG00000022125
resolver
ensp
ENSMUSP00000022721
resolver
enst
ENSMUST00000022721
resolver
genesymbol
Cln5
resolver
genesymbol_syn
Bmps
resolver
uniprot
B2RUP8
resolver
uniprot
Q8C054
resolver
uniprot
Q8R152
resolver
uniprot_entry
B2RUP8_MOUSE
resolver
uniprot_entry
CLN5_MOUSE
resolver
uniprot_sec
Q8C054
resolver
uniprot_sec
Q8R152
resolver
amino_acid_sequence
MLRGGPCGAHWRPALALALLGLATILGASPTSGQRWPVPYKRFSFRPKTDPYCQAKYTFCPTGSPIPVMKDNDVIEVLRLQAPIWEFKYGDLLGHFKLMHDAVGFRSTLTGKNYTIEWYELFQLGNCTFPHLRPDKSAPFWCNQGAACFFEGIDDKHWKENGTLSVVATISGNTFNKVAEWVKQDNETGIYYETWTVRAGPGQGAQTWFESYDCSNFVLRTYKKLAEFGTEFKKIETNYTKIFLYSGEPIYLGNETSIFGPKGNKTLALAIKKFYGPFRPYLSTKDFLMNFLKIFDTVIIHRQFYLFYNFEYWFLPMKPPFVKITYEETPLPTRHTTFTDL
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
function
FUNCTION: [Bis(monoacylglycero)phosphate synthase CLN5, secreted form]: Catalyzes the synthesis of bis(monoacylglycero)phosphate (BMP) via transacylation of 2 molecules of lysophosphatidylglycerol (LPG). BMP also known as lysobisphosphatidic acid plays a key role in the formation of intraluminal vesicles and in maintaining intracellular cholesterol homeostasis. Can use only LPG as the exclusive lysophospholipid acyl donor for base exchange and displays BMP synthase activity towards various LPGs (LPG 14:0, LPG 16:0, LPG 18:0, LPG 18:1) with a higher preference for longer chain lengths. Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane. {ECO:0000250|UniProtKB:O75503}.; FUNCTION: Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation. {ECO:0000269|PubMed:35427157}.
uniprot
proteins
mass_dalton
39329
uniprot
proteins
post_translational_modification
PTM: N-glycosylated with both high mannose and complex type sugars. Glycosylation is important for proper folding and trafficking to the lysosomes. {ECO:0000250|UniProtKB:O75503}.; PTM: [Bis(monoacylglycero)phosphate synthase CLN5]: The type II membrane signal anchor is proteolytically cleaved to produce a mature form that is transported to the lysosomes (Bis(monoacylglycero)phosphate synthase CLN5, secreted form). {ECO:0000250|UniProtKB:O75503}.; PTM: Can undergo proteolytic cleavage at the C-terminus, probably by a cysteine protease and may involve the removal of approximately 10-15 residues from the C-terminal end (PubMed:26342652). {ECO:0000269|PubMed:26342652}.; PTM: Ubiquitinated by the E3 ubiquitin ligase complex at least composed of CUL3, KCTD7 and RBX1 leading to proteasomal degradation. {ECO:0000250|UniProtKB:O75503}.
uniprot
proteins
protein_family
CLN5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19941651
uniprot
proteins
pubmed
20052765
uniprot
proteins
pubmed
26342652
uniprot
proteins
pubmed
35427157
uniprot
proteins
sequence_length
341
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Bis(monoacylglycero)phosphate synthase CLN5, secreted form]: Lysosome {ECO:0000269|PubMed:20052765}.; SUBCELLULAR LOCATION: [Bis(monoacylglycero)phosphate synthase CLN5]: Membrane {ECO:0000250|UniProtKB:O75503}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O75503}. Note=An amphipathic anchor region facilitates its association with the membrane. {ECO:0000250|UniProtKB:O75503}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..30; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins