PRC1
entrez
9055
canonical
uniprot
O43663
canonical
ensembl
ENSG00000198901
resolver
ensp
ENSP00000354679
resolver
ensp
ENSP00000377793
resolver
ensp
ENSP00000409549
resolver
ensp
ENSP00000655679
resolver
ensp
ENSP00000697253
resolver
ensp
ENSP00000734512
resolver
ensp
ENSP00000734516
resolver
ensp
ENSP00000734522
resolver
genesymbol
PRC1
resolver
hgnc
HGNC:9341
resolver
uniprot
A6NC44
resolver
uniprot
B4DLR1
resolver
uniprot
H9KV59
resolver
uniprot
Q9BSB6
resolver
uniprot_entry
PRC1_HUMAN
resolver
uniprot_sec
A6NC44
resolver
uniprot_sec
B4DLR1
resolver
uniprot_sec
H9KV59
resolver
uniprot_sec
Q9BSB6
resolver
amino_acid_sequence
MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEALDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTGRHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQRELSKASKSDATSGILNSTNIQS
uniprot
proteins
function
FUNCTION: Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}.
uniprot
proteins
mass_dalton
71607
uniprot
proteins
mutagenesis
MUTAGEN 470; /note="T->A: No effect. Abolishes CDK1-mediated phosphorylation, leading to prematurely recruit PLK1 to the spindle during prometaphase and blocking mitotic progression; when associated with A-481."; /evidence="ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:9885575"; MUTAGEN 481; /note="T->A: No effect. Reduces in vitro cyclin E-CDK2 phosphorylation and causes extensive bundling of microtubules to the mitotic spindle; when associated with A-470."; /evidence="ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:9885575"; MUTAGEN 577..578; /note="ST->AA: Weakly reduces binding to the POLO box domains of PLK1."; /evidence="ECO:0000269|PubMed:17351640"; MUTAGEN 615..616; /note="ST->AA: Impairs binding to the POLO box domains of PLK1, preventing phosphorylation by PLK1 and recruitment of PLK1 to the spindle."; /evidence="ECO:0000269|PubMed:17351640
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by CDK1 in early mitosis holds PRC1 in an inactive monomeric state, during the metaphase to anaphase transition, PRC1 is dephosphorylated, promoting interaction with KIF4A, which then translocates PRC1 along mitotic spindles to the plus ends of antiparallel interdigitating microtubules. Dephosphorylation also promotes MT-bundling activity by allowing dimerization. Phosphorylation by CDK1 prevents PLK1-binding: upon degradation of CDK1 at anaphase and dephosphorylation, it is then phosphorylated by PLK1, leading to cytokinesis. {ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17438553, ECO:0000269|PubMed:9885575}.
uniprot
proteins
protein_family
MAP65/ASE1 family
uniprot
proteins
pubmed
12082078
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14744859
uniprot
proteins
pubmed
15297875
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15625105
uniprot
proteins
pubmed
16431929
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17351640
uniprot
proteins
pubmed
17409436
uniprot
proteins
pubmed
17438553
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19468300
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20691902
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29848660
uniprot
proteins
pubmed
35849559
uniprot
proteins
pubmed
36825683
uniprot
proteins
pubmed
9885575
uniprot
proteins
sequence_length
620
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17409436}. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105}. Midbody {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:35849559, ECO:0000269|PubMed:36825683}. Chromosome {ECO:0000269|PubMed:15297875}. Note=Colocalized with KIF20B in the nucleus of bladder carcinoma cells at the interphase. Colocalized with KIF20B in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (PubMed:17409436). Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes with the cell midbody during cytokinesis. Co-localizes with PRC1 in early mitosis and at the spindle midzone from anaphase B to telophase (PubMed:15297875, PubMed:15625105). {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:17409436}.
uniprot
proteins