QSCN6
entrez
5768
canonical
uniprot
O00391
canonical
ensembl
ENSG00000116260
resolver
ensp
ENSP00000356572
resolver
ensp
ENSP00000356574
resolver
genesymbol
QSCN6
resolver
genesymbol
QSOX1
resolver
genesymbol_syn
QSCN6
resolver
hgnc
HGNC:9756
resolver
uniprot
A0A140VKE5
resolver
uniprot
Q59G29
resolver
uniprot
Q5T2X0
resolver
uniprot
Q8TDL6
resolver
uniprot
Q8WVP4
resolver
uniprot_entry
A0A140VKE5_HUMAN
resolver
uniprot_entry
QSOX1_HUMAN
resolver
uniprot_sec
Q59G29
resolver
uniprot_sec
Q5T2X0
resolver
uniprot_sec
Q8TDL6
resolver
uniprot_sec
Q8WVP4
resolver
amino_acid_sequence
MRRCNSGSGPPPSLLLLLLWLLAVPGANAAPRSALYSPSDPLTLLQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVRFFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPACPPLEPAKLEEIDGFFARNNEEYLALIFEKGGSYLGREVALDLSQHKGVAVRRVLNTEANVVRKFGVTDFPSCYLLFRNGSVSRVPVLMESRSFYTAYLQRLSGLTREAAQTTVAPTTANKIAPTVWKLADRSKIYMADLESALHYILRIEVGRFPVLEGQRLVALKKFVAVLAKYFPGRPLVQNFLHSVNEWLKRQKRNKIPYSFFKTALDDRKEGAVLAKKVNWIGCQGSEPHFRGFPCSLWVLFHFLTVQAARQNVDHSQEAAKAKEVLPAIRGYVHYFFGCRDCASHFEQMAAASMHRVGSPNAAVLWLWSSHNRVNARLAGAPSEDPQFPKVQWPPRELCSACHNERLDVPVWDVEATLNFLKAHFSPSNIILDFPAAGSAARRDVQNVAAAPELAMGALELESRNSTLDPGKPEMMKSPTNTTPHVPAEGPEASRPPKLHPGLRAAPGQEPPEHMAELQRNEQEQPLGQWHLSKRDTGAALLAESRAEKNRLWGPLEVRRVGRSSKQLVDIPEGQLEARAGRGRGQWLQVLGGGFSYLDISLCVGLYSLSFMGLLAMYTYFQAKIRALKGHAGHPAA
uniprot
proteins
ec_number
1.8.3.2
uniprot
proteins
function
FUNCTION: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:23867277, PubMed:30367560). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:22801504, PubMed:23867277, PubMed:30367560). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:23867277, PubMed:30367560). {ECO:0000269|PubMed:17331072, ECO:0000269|PubMed:18393449, ECO:0000269|PubMed:22801504, ECO:0000269|PubMed:23704371, ECO:0000269|PubMed:23867277, ECO:0000269|PubMed:30367560}.
uniprot
proteins
mass_dalton
82578
uniprot
proteins
mutagenesis
MUTAGEN 70..73; /note="CGHC->AGHA: Loss of catalytic activity. Cannot prevent cell detachment after depletion of the endogenous protein."; /evidence="ECO:0000269|PubMed:23704371, ECO:0000269|PubMed:30367560"; MUTAGEN 70; /note="C->S: Reduces activity by 93%."; /evidence="ECO:0000269|PubMed:18393449"; MUTAGEN 72; /note="H->A: Decreased protein stability and catalytic activity; when associated with S-119 or T-119."; /evidence="ECO:0000269|PubMed:30367560"; MUTAGEN 73; /note="C->S: Reduces activity by 93%."; /evidence="ECO:0000269|PubMed:18393449"; MUTAGEN 119; /note="P->S,T: Loss of catalytic activity. Decreased protein stability and catalytic activity; when associated with A-72."; /evidence="ECO:0000269|PubMed:30367560"; MUTAGEN 130; /note="N->Q: Loss of glycosylation site."; /evidence="ECO:0000269|PubMed:29757379"; MUTAGEN 243; /note="N->Q: Loss of glycosylation site. Abolishes secretion. No effect on catalytic activity."; /evidence="ECO:0000269|PubMed:29757379"; MUTAGEN 276..282; /note="TTVAPTT->ANVAPVA: Decreased O-glycosylation."; /evidence="ECO:0000269|PubMed:29757379"; MUTAGEN 449; /note="C->S: Reduces activity by 96%."; /evidence="ECO:0000269|PubMed:18393449"; MUTAGEN 452; /note="C->S: Loss of activity."; /evidence="ECO:0000269|PubMed:18393449"; MUTAGEN 509; /note="C->S: No effect. Reduces activity by 70%; when associated with S-512."; /evidence="ECO:0000269|PubMed:18393449"; MUTAGEN 512; /note="C->S: Reduces activity by 40%. Reduces activity by 70%; when associated with S-509."; /evidence="ECO:0000269|PubMed:18393449
uniprot
proteins
post_translational_modification
PTM: N-glycosylated (PubMed:17331072, PubMed:29757379). O-glycosylated on Thr and Ser residues (PubMed:29757379). {ECO:0000269|PubMed:17331072, ECO:0000269|PubMed:29757379}.
uniprot
proteins
protein_family
Quiescin-sulfhydryl oxidase (QSOX) family
uniprot
proteins
pubmed
10708601
uniprot
proteins
pubmed
12176051
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16806532
uniprot
proteins
pubmed
17331072
uniprot
proteins
pubmed
18393449
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
20211621
uniprot
proteins
pubmed
22801504
uniprot
proteins
pubmed
23704371
uniprot
proteins
pubmed
23867277
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
26819240
uniprot
proteins
pubmed
29757379
uniprot
proteins
pubmed
30367560
uniprot
proteins
pubmed
9878249
uniprot
proteins
sequence_length
747
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus membrane {ECO:0000269|PubMed:17331072, ECO:0000269|PubMed:23704371}; Single-pass membrane protein {ECO:0000305|PubMed:17331072}. Secreted {ECO:0000269|PubMed:29757379}. Note=A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor. {ECO:0000305|PubMed:29757379}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:10708601}. Note=Found in the extracellular medium of quiescent cells but is not found in proliferating cells. {ECO:0000269|PubMed:10708601}.
uniprot
proteins
transmembrane_region
TRANSMEM 710..730; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins