Kat8
entrez
67773
canonical
uniprot
Q9D1P2
canonical
ensembl
ENSMUSG00000030801
resolver
ensp
ENSMUSP00000033070
resolver
genesymbol
Kat8
resolver
genesymbol_syn
Mof
resolver
genesymbol_syn
Myst1
resolver
uniprot
Q3UIY0
resolver
uniprot
Q8BJ69
resolver
uniprot
Q8BJ76
resolver
uniprot
Q8CI73
resolver
uniprot_entry
KAT8_MOUSE
resolver
uniprot_sec
Q3UIY0
resolver
uniprot_sec
Q8BJ69
resolver
uniprot_sec
Q8BJ76
resolver
uniprot_sec
Q8CI73
resolver
activity_regulation
ACTIVITY REGULATION: The acetyltransferase activity is inhibited by anacardic acid derivatives. {ECO:0000250|UniProtKB:Q9H7Z6}.
uniprot
proteins
amino_acid_sequence
MAAQGATAAVAATTSGTVGEGEPGPGENAAVEGPARSPGRVSPPTPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKFEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.48
uniprot
proteins
function
FUNCTION: Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context (PubMed:24842875, PubMed:24898753, PubMed:31794431, PubMed:32502394). Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:17967868, PubMed:18541669, PubMed:24898753, PubMed:28506985). H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism (PubMed:27827827, PubMed:28506985, PubMed:32502394, PubMed:34707105). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (By similarity). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (PubMed:23523075). X up-regulation is required to compensate for autosomal biallelic expression (PubMed:23523075). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (PubMed:24842875). As part of the NSL histone acetyltransferase complex, catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (By similarity). The NSL complex also acts as a regulator of gene expression in mitochondria: KAT8 associates with mitochondrial DNA and controls expression of respiratory genes in an acetyltransferase-dependent mechanism (PubMed:27768893). Also functions as an acetyltransferase for non-histone targets, such as ALKBH5, COX17, IRF3, KDM1A/LSD1, LMNA, PAX7 or TP53/p53 (PubMed:30842237, PubMed:31576060, PubMed:34059674). Acts as an inhibitor of antiviral immunity by acetylating IRF3, preventing IRF3 recruitment to promoters (PubMed:30842237). Acts as a regulator of asymmetric division in muscle stem cells by mediating acetylation of PAX7 (PubMed:34059674). As part of the NSL complex, acetylates TP53/p53 at 'Lys-120' (By similarity). Acts as a regulator of epithelial-to-mesenchymal transition as part of the NSL complex by mediating acetylation of KDM1A/LSD1 (By similarity). The NSL complex is required for nuclear architecture maintenance by mediating acetylation of LMNA (PubMed:31576060). Promotes mitochondrial integrity by catalyzing acetylation of COX17 (PubMed:37813994). In addition to protein acetyltransferase activity, able to mediate protein propionylation (By similarity). {ECO:0000250|UniProtKB:Q9H7Z6, ECO:0000269|PubMed:17967868, ECO:0000269|PubMed:18541669, ECO:0000269|PubMed:23523075, ECO:0000269|PubMed:24842875, ECO:0000269|PubMed:24898753, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:27827827, ECO:0000269|PubMed:28506985, ECO:0000269|PubMed:30842237, ECO:0000269|PubMed:31576060, ECO:0000269|PubMed:31794431, ECO:0000269|PubMed:32502394, ECO:0000269|PubMed:34059674, ECO:0000269|PubMed:34707105, ECO:0000269|PubMed:37813994}.
uniprot
proteins
mass_dalton
52574
uniprot
proteins
mutagenesis
MUTAGEN 274; /note="K->R: Abolished ability to acetylate proteins."; /evidence="ECO:0000269|PubMed:30842237"; MUTAGEN 350; /note="E->Q: Abolished protein acetyltransferase activity."; /evidence="ECO:0000269|PubMed:31576060
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-274 facilitates cognate substrate Lys-binding and acetylation (By similarity). Although considered as an autoacetylation event, acetylation at Lys-274 probably takes place via a non-enzymatic process following acetyl-CoA-binding, which primes KAT8 for cognate protein-lysine acetylation (By similarity). {ECO:0000250|UniProtKB:Q9H7Z6}.
uniprot
proteins
protein_family
MYST (SAS/MOZ) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17335777
uniprot
proteins
pubmed
17967868
uniprot
proteins
pubmed
18541669
uniprot
proteins
pubmed
21217699
uniprot
proteins
pubmed
23523075
uniprot
proteins
pubmed
24842875
uniprot
proteins
pubmed
24898753
uniprot
proteins
pubmed
27768893
uniprot
proteins
pubmed
27827827
uniprot
proteins
pubmed
28506985
uniprot
proteins
pubmed
30842237
uniprot
proteins
pubmed
31576060
uniprot
proteins
pubmed
31794431
uniprot
proteins
pubmed
32502394
uniprot
proteins
pubmed
34059674
uniprot
proteins
pubmed
34707105
uniprot
proteins
pubmed
37813994
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28506985, ECO:0000305|PubMed:31794431}. Chromosome {ECO:0000269|PubMed:23523075, ECO:0000269|PubMed:24842875, ECO:0000269|PubMed:24898753, ECO:0000305|PubMed:31794431}. Mitochondrion {ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:37813994}. Note=Translocated into the nucleus via its association with importin-alpha-1 (KPNA2) (By similarity). As part of the NSL complex, associates with the proximal part of promoters and transcription start sites (PubMed:23523075, PubMed:24842875, PubMed:24898753). As part of the MSL complex, associates with gene bodies (PubMed:24898753). Also localizes to mitochondria; associates with mitochondrial DNA and regulates mitochondrial gene expression (PubMed:27768893). {ECO:0000250|UniProtKB:Q9H7Z6, ECO:0000269|PubMed:23523075, ECO:0000269|PubMed:24842875, ECO:0000269|PubMed:24898753, ECO:0000269|PubMed:27768893}.
uniprot
proteins