CCDC86
entrez
79080
canonical
uniprot
Q9H6F5
canonical
ensembl
ENSG00000110104
resolver
ensp
ENSP00000227520
resolver
genesymbol
CCDC86
resolver
genesymbol_syn
CYCLON
resolver
hgnc
HGNC:28359
resolver
uniprot
B4DY99
resolver
uniprot_entry
CCD86_HUMAN
resolver
uniprot_sec
B4DY99
resolver
amino_acid_sequence
MDTPLRRSRRLGGLRPESPESLTSVSRTRRALVEFESNPEETREPGSPPSVQRAGLGSPERPPKTSPGSPRLQQGAGLESPQGQPEPGAASPQRQQDLHLESPQRQPEYSPESPRCQPKPSEEAPKCSQDQGVLASELAQNKEELTPGAPQHQLPPVPGSPEPYPGQQAPGPEPSQPLLELTPRAPGSPRGQHEPSKPPPAGETVTGGFGAKKRKGSSSQAPASKKLNKEELPVIPKGKPKSGRVWKDRSKKRFSQMLQDKPLRTSWQRKMKERQERKLAKDFARHLEEEKERRRQEKKQRRAENLKRRLENERKAEVVQVIRNPAKLKRAKKKQLRSIEKRDTLALLQKQPPQQPAAKI
uniprot
proteins
function
FUNCTION: Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}.
uniprot
proteins
mass_dalton
40236
uniprot
proteins
mutagenesis
MUTAGEN 1..63; /note="Missing: Loss of localization to chromosomes during mitosis."; /evidence="ECO:0000269|PubMed:36695333
uniprot
proteins
post_translational_modification
PTM: Citrullinated by PADI4. {ECO:0000250|UniProtKB:Q9JJ89}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15607035
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17300783
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
36695333
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17300783}. Chromosome {ECO:0000269|PubMed:36695333}. Nucleus, nucleolus {ECO:0000269|PubMed:36695333}. Note=Localized to the nucleolus during the interphase and localized to the perichromosomal layer (also known as chromosome periphery) during mitosis; is particularly enriched at the perichromosomal layer during anaphase. Colocalizes with MKI67 during interphase and mitotic exit. {ECO:0000269|PubMed:36695333}.
uniprot
proteins