F11R
entrez
50848
canonical
uniprot
Q9Y624
canonical
ensembl
ENSG00000158769
resolver
ensp
ENSP00000357005
resolver
ensp
ENSP00000440812
resolver
ensp
ENSP00000560945
resolver
genesymbol
F11R
resolver
genesymbol_syn
JAM1
resolver
genesymbol_syn
JCAM
resolver
hgnc
HGNC:14685
resolver
uniprot
B7Z941
resolver
uniprot
Q6FIB4
resolver
uniprot_entry
JAM1_HUMAN
resolver
uniprot_entry
Q6FIB4_HUMAN
resolver
uniprot_sec
B7Z941
resolver
amino_acid_sequence
MGTKAQVERKLLCLFILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVGVIVAAVLVTLILLGILVFGIWFAYSRGHFDRTKKGTSSKKVIYSQPSARSEGEFKQTSSFLV
uniprot
proteins
function
FUNCTION: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840). {ECO:0000250|UniProtKB:O88792, ECO:0000269|PubMed:10753840, ECO:0000269|PubMed:11489913, ECO:0000269|PubMed:11812992}.; FUNCTION: (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. {ECO:0000269|PubMed:11239401}.; FUNCTION: (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. {ECO:0000269|PubMed:25481868}.
uniprot
proteins
mass_dalton
32583
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7646439}.; PTM: (Microbial infection) Cleaved by H.pylori virulence factor PqqE. Cleavage leads to altered tight junction functions. {ECO:0000269|PubMed:33970782}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
10395639
uniprot
proteins
pubmed
10753840
uniprot
proteins
pubmed
11171323
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11239401
uniprot
proteins
pubmed
11489913
uniprot
proteins
pubmed
11812992
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12697893
uniprot
proteins
pubmed
12810109
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15528364
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19079583
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25481868
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
33970782
uniprot
proteins
pubmed
35067832
uniprot
proteins
pubmed
7646439
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:11171323}. Cell membrane {ECO:0000269|PubMed:11171323}; Single-pass type I membrane protein {ECO:0000269|PubMed:11171323}. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000269|PubMed:11171323}.
uniprot
proteins
transmembrane_region
TRANSMEM 239..259; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins