Mafg
entrez
64188
canonical
uniprot
Q76MX4
canonical
ensembl
ENSRNOG00000072854
resolver
ensembl
ENSRNOG00055030545
resolver
ensembl
ENSRNOG00060021339
resolver
ensembl
ENSRNOG00065004235
resolver
ensp
ENSRNOP00000102247
resolver
ensp
ENSRNOP00000108082
resolver
enst
ENSRNOT00000144958
resolver
genesymbol
Mafg
resolver
uniprot
A0ABK0LZI7
resolver
uniprot
Q99N83
resolver
uniprot_entry
A0ABK0LZI7_RAT
resolver
uniprot_entry
MAFG_RAT
resolver
uniprot_sec
Q99N83
resolver
amino_acid_sequence
MTTPNKGNKALKVSGEAGLGVCWAGHSYSALTPCAVPLQVKREPGENGTSLTDEELVTMSVRELNQHLRGLSKEEIIQLKQRRRTLKNRGYAASCRVKRVTQKEELEKQKAELQQEVEKLASENASMKLELDALRSKYEALQNFARTVARSPVAPARGPLAAGLGPLVPGKVAATSVITIVKSKTDARS
uniprot
proteins
function
FUNCTION: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (By similarity). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (By similarity). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (By similarity). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (By similarity). Activates globin gene expression when associated with NFE2L2 (By similarity). May be involved in signal transduction of extracellular H(+) (PubMed:11583919). {ECO:0000250|UniProtKB:O15525, ECO:0000269|PubMed:11583919}.
uniprot
proteins
mass_dalton
20533
uniprot
proteins
post_translational_modification
PTM: Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2. {ECO:0000250|UniProtKB:O15525}.; PTM: Sumoylation at Lys-41 is required for active transcriptional repression. {ECO:0000250|UniProtKB:O54790}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
Maf subfamily
uniprot
proteins
pubmed
10724342
uniprot
proteins
pubmed
11583919
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O15525, ECO:0000255|PROSITE-ProRule:PRU00978}.
uniprot
proteins