Mad2l1
entrez
56150
canonical
uniprot
Q9Z1B5
canonical
ensembl
ENSMUSG00000029910
resolver
ensp
ENSMUSP00000098897
resolver
ensp
ENSMUSP00000112304
resolver
enst
ENSMUST00000101343
resolver
enst
ENSMUST00000116605
resolver
genesymbol
Mad2l1
resolver
genesymbol_syn
Mad2a
resolver
uniprot
Q5HZH8
resolver
uniprot
Q9JI53
resolver
uniprot_entry
MD2L1_MOUSE
resolver
uniprot_entry
Q5HZH8_MOUSE
resolver
uniprot_sec
Q9JI53
resolver
amino_acid_sequence
MAQQLAREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLTTTDPELIKYLNNVVEQLKEWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKEEGVRREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNCEEVRLRSFTTTIHKVNSMVAYKTPVND
uniprot
proteins
function
FUNCTION: Component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle (By similarity). The MCC, which consists of CDC20, MAD2L1/MAD2, BUB1B/BUBR1 and BUB3, is a key player of the spindle assembly checkpoint (By similarity). The MCC-bound APC/C complex is inactive and this delays the metaphase/anaphase transition (By similarity). When the spindle assembly checkpoint is silenced, the MCC-APC/C complex recruits the E2 enzyme UBCH10 and triggers the auto-ubiquitination of CDC20 in the MCC, thereby reactivating APC/C for transition into anaphase (By similarity). In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2 (By similarity). {ECO:0000250|UniProtKB:Q13257}.
uniprot
proteins
mass_dalton
23598
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on multiple serine residues (By similarity). The level of phosphorylation varies during the cell cycle and is highest during mitosis (By similarity). Phosphorylation abolishes interaction with MAD1L1 and reduces interaction with CDC20 (By similarity). Phosphorylated by NEK2 (By similarity). {ECO:0000250|UniProtKB:Q13257}.
uniprot
proteins
protein_family
MAD2 family
uniprot
proteins
pubmed
10892650
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13257}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm {ECO:0000250|UniProtKB:Q13257}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Recruited by MAD1L1 to unattached kinetochores (By similarity). Recruited to the nuclear pore complex by TPR during interphase (By similarity). Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2 (By similarity). {ECO:0000250}.
uniprot
proteins