Lyset
entrez
100360358
canonical
uniprot
F1LXS7
canonical
ensembl
ENSRNOG00000008101
resolver
ensembl
ENSRNOG00055016152
resolver
ensembl
ENSRNOG00060004893
resolver
ensp
ENSRNOP00000010672
resolver
ensp
ENSRNOP00055022014
resolver
ensp
ENSRNOP00060006112
resolver
enst
ENSRNOT00000010672
resolver
enst
ENSRNOT00055027403
resolver
enst
ENSRNOT00060008144
resolver
genesymbol
Lyset
resolver
genesymbol_syn
Tmem251
resolver
uniprot_entry
LYSET_RAT
resolver
amino_acid_sequence
MPKAPDYSELSDSCTLAGGTARFSGPLHRAWRMMNFRQRMGWIGVGLYLLASAAAFYYVFEINETYNRLALEHIQQHPEEPREGTTWTHSLKARLLSLPFWLWTVIFLIPYLQMFLFLYSCTRADPKTVGYCIIPICLAIICNRHQAFVKASNQISRLQLIDT
uniprot
proteins
function
FUNCTION: Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes. LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB. GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes. LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases. {ECO:0000250|UniProtKB:Q8N6I4}.
uniprot
proteins
mass_dalton
18823
uniprot
proteins
protein_family
LYSET family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
36096887
uniprot
proteins
sequence_length
163
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:36096887}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with GNPTAB and GNPTG in Golgi apparatus cisternae. {ECO:0000250|UniProtKB:Q8N6I4}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..119; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins