Rhou
entrez
69581
canonical
uniprot
Q9EQT3
canonical
ensembl
ENSMUSG00000039960
resolver
ensp
ENSMUSP00000038915
resolver
enst
ENSMUST00000045487
resolver
genesymbol
Rhou
resolver
genesymbol_syn
Arhu
resolver
genesymbol_syn
G28k
resolver
genesymbol_syn
Wrch1
resolver
uniprot_entry
RHOU_MOUSE
resolver
amino_acid_sequence
MAPQQGRPALPARCEPPAAPPVPPRRERGGRGARGPGVSGGRGRAGGAEGRGVKCVLVGDGAVGKTSLVVSYTTNGYPTEYIPTAFDNFSAVVSVDGRPVRLQLCDTAGQDEFDKLRPLCYTNTDIFLLCFSVVSPTSFQNVGEKWVPEIRRHCPKAPIILVGTQSDLREDVKVLIELDKCKEKPVPEEAAKLCAEEVKAVSYIECSALTQKNLKEVFDAAIVAGIQHSDSQLQPKKSKSRTPDKVRDLSKSWWRKYCCLA
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Binds to and activates protein kinase PAK1. Plays a role in the regulation of cell morphology, cytoskeletal organization and focal adhesion assembly during cell migration. Also stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. {ECO:0000250|UniProtKB:Q7L0Q8}.
uniprot
proteins
mass_dalton
28354
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated by SRC in response to PTK2B/PYK2 activation. {ECO:0000250}.; PTM: Ubiquitinated. 'Lys-48'-linked ubiquitination at Lys-180 and Lys-251 by the ECS(RAB40A) complex leading to its degradation. {ECO:0000250|UniProtKB:Q7L0Q8}.
uniprot
proteins
protein_family
Rho family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11459829
uniprot
proteins
pubmed
14731133
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7L0Q8}; Lipid-anchor {ECO:0000250|UniProtKB:Q7L0Q8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q7L0Q8}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q7L0Q8}; Lipid-anchor {ECO:0000250|UniProtKB:Q7L0Q8}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q7L0Q8}. Cell projection, podosome {ECO:0000250|UniProtKB:Q7L0Q8}. Note=Localizes to podosomes in SRC-transformed cells. {ECO:0000250|UniProtKB:Q7L0Q8}.
uniprot
proteins