Cyp2c40
entrez
13099
canonical
uniprot
P56657
canonical
ensembl
ENSMUSG00000025004
resolver
ensp
ENSMUSP00000125217
resolver
ensp
ENSMUSP00000158887
resolver
enst
ENSMUST00000160476
resolver
enst
ENSMUST00000239028
resolver
genesymbol
Cyp2c40
resolver
uniprot
B2RTP3
resolver
uniprot
E9Q7C8
resolver
uniprot_entry
CP240_MOUSE
resolver
uniprot_entry
E9Q7C8_MOUSE
resolver
uniprot_sec
B2RTP3
resolver
amino_acid_sequence
MDPFVVLVLCLSFLLVLSLWRQRSARGNLPPGPTPLPIIGNYHLIDMKDIGQCLTNFSKTYGPVFTLYFGSQPIVVLHGYEAIKEALIDHGEEFSGRGRIPVFDKVSTGKGIGFSHGNVWKATRVFTVNTLRNLGMGKRTIENKVQEEAQWLMKELKKTNGSPCDPQFIIGCAPCNVICSIVFQNRFDYKDKDFLSLIGKVNECTEILSSPGCQIFNAVPILIDYCPGSHNKLFKNHTWIKSYLLGKIKEHEESLDVTNPRDFIDYFLIQRRQKNGIEHMDYTIEHLATLVTDLVFGGTETLSSTMRFALLLLMKHTHITAKVQEEIDNVIGRHRSPCMQDRNHMPYTNAMVHEVQRYIDLGPNGVVHEVTCDTKFRNYFIPKGTQVMTSLTSVLHDSTEFPNPEVFDPGHFLDDNGNFKKSDYFVPFSAGKRICVGESLARMELFLFLTTILQNFKLKPLVDPKDIDMTPKHSGFSKIPPNFQMCFIPVE
uniprot
proteins
ec_number
1.14.14.-
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase that may play a major role in the metabolism of arachidonic acid in the intestinal tract (PubMed:10908295, PubMed:9721182). Exhibits regioselective hydroxylase and epoxidase activity toward arachidonic acid, producing 16(R)-hydroxyeicosatetraenoic acid (HETE) and (14R,15S)-epoxyeicosatrienoic acid (EpETrE) as major products (PubMed:10908295). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10908295). {ECO:0000269|PubMed:10908295, ECO:0000269|PubMed:9721182}.
uniprot
proteins
mass_dalton
55763
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; arachidonate metabolism. {ECO:0000305|PubMed:10908295}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10908295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9721182
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
uniprot
proteins