Cyb561
entrez
13056
canonical
uniprot
Q60720
canonical
ensembl
ENSMUSG00000019590
resolver
ensp
ENSMUSP00000019734
resolver
ensp
ENSMUSP00000138931
resolver
ensp
ENSMUSP00000303991
resolver
ensp
ENSMUSP00000303999
resolver
ensp
ENSMUSP00000304003
resolver
ensp
ENSMUSP00000304004
resolver
ensp
ENSMUSP00000304008
resolver
enst
ENSMUST00000019734
resolver
enst
ENSMUST00000184086
resolver
genesymbol
Cyb561
resolver
genesymbol_syn
Mcyt
resolver
uniprot
Q3TEC6
resolver
uniprot
Q9D6C9
resolver
uniprot
V9GX11
resolver
uniprot_entry
CY561_MOUSE
resolver
uniprot_entry
V9GX11_MOUSE
resolver
uniprot_sec
Q3TEC6
resolver
uniprot_sec
Q9D6C9
resolver
amino_acid_sequence
MEHSSASVPAALPYYVAFSQLLGLTVVAVTGAWLGLYRGGIAWESSLQFNVHPLCMVIGMIFLQGDALLVYRVFRREAKRTTKILHGLLHVFAFIIALVGLVAVFDYHKKKGYADLYSLHSWCGILVFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLFSVGTALLGLKEALLFKLGSKYSTFEPEGVLANVLGLLLVCFGVVVLYILAQADWKRPSQAEEQALSMDFKTLTEGDSPSPQ
uniprot
proteins
ec_number
7.2.1.3
uniprot
proteins
function
FUNCTION: Transmembrane reductase that probably uses ascorbate as an electron donor to reduce Fe(3+) into Fe(2+) and could play a role in iron transport (PubMed:14499595). It is also able to reduce extracellular monodehydro-L-ascorbate and could be involved in the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes (PubMed:16256064). {ECO:0000269|PubMed:14499595, ECO:0000269|PubMed:16256064}.
uniprot
proteins
mass_dalton
27822
uniprot
proteins
mutagenesis
MUTAGEN 52; /note="H->A: Decreased protein abundance."; /evidence="ECO:0000269|PubMed:16256064"; MUTAGEN 72; /note="R->A: No effect on protein abundance. Decreased reduction by ascorbate."; /evidence="ECO:0000269|PubMed:16256064"; MUTAGEN 83; /note="K->A: No effect on protein abundance."; /evidence="ECO:0000269|PubMed:16256064"; MUTAGEN 86; /note="H->A: No effect on protein abundance. Decreased reduction by ascorbate; when associated with A-159."; /evidence="ECO:0000269|PubMed:16256064"; MUTAGEN 108; /note="H->A: No effect on protein abundance."; /evidence="ECO:0000269|PubMed:16256064"; MUTAGEN 120; /note="H->A: Decreased protein abundance."; /evidence="ECO:0000269|PubMed:16256064"; MUTAGEN 159; /note="H->A: No effect on protein abundance. Decreased reduction by ascorbate; when associated with A-86."; /evidence="ECO:0000269|PubMed:16256064
uniprot
proteins
pubmed
14499595
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16256064
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29343526
uniprot
proteins
pubmed
9778036
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000269|PubMed:16256064}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}. Note=Secretory vesicle containing catecholamines and amidated peptides. {ECO:0000250|UniProtKB:P10897}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 51..71; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 124..144; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 198..218; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins