Cd38
entrez
12494
canonical
uniprot
P56528
canonical
ensembl
ENSMUSG00000029084
resolver
ensp
ENSMUSP00000030964
resolver
enst
ENSMUST00000030964
resolver
genesymbol
Cd38
resolver
uniprot
Q3UCS6
resolver
uniprot
Q4FJL8
resolver
uniprot
Q8BFY8
resolver
uniprot_entry
CD38_MOUSE
resolver
uniprot_entry
Q3UCS6_MOUSE
resolver
uniprot_entry
Q4FJL8_MOUSE
resolver
uniprot_sec
Q8BFY8
resolver
amino_acid_sequence
MANYEFSQVSGDRPGCRLSRKAQIGLGVGLLVLIALVVGIVVILLRPRSLLVWTGEPTTKHFSDIFLGRCLIYTQILRPEMRDQNCQEILSTFKGAFVSKNPCNITREDYAPLVKLVTQTIPCNKTLFWSKSKHLAHQYTWIQGKMFTLEDTLLGYIADDLRWCGDPSTSDMNYVSCPHWSENCPNNPITVFWKVISQKFAEDACGVVQVMLNGSLREPFYKNSTFGSVEVFSLDPNKVHKLQAWVMHDIEGASSNACSSSSLNELKMIVQKRNMIFACVDNYRPARFLQCVKNPEHPSCRLNT
uniprot
proteins
ec_number
2.4.99.20
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: Multifunctional transmembrane glycoprotein able to exert enzymatic activities and also to mobilize calcium, to transduce signals, to adhere to hyaluronan and to other ligands. Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid (PubMed:11829748). At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity. Functions also as a receptor that binds the ligand CD31 on endothelial cells, promoting lymphocyte activation, proliferation, and migration across the endothelial barrier. Involved in the regulation of crucial dendritic cell functions acquired at the mature stage, such as CCL21-driven migration, survival, and Th1-polarizing activity. In lamina propria T lymphocytes, CD38/CD31 cognate interactions initiate a multistep signaling pathway resulting in activation of LCK anf LAT, followed by cytokine release. {ECO:0000250|UniProtKB:P28907, ECO:0000269|PubMed:11829748}.
uniprot
proteins
mass_dalton
34408
uniprot
proteins
protein_family
ADP-ribosyl cyclase family
uniprot
proteins
pubmed
11829748
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8376770
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:11829748, ECO:0000305|PubMed:8376770}; Single-pass type II membrane protein {ECO:0000305|PubMed:8376770}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..44; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins