Prdm6
entrez
225518
canonical
uniprot
Q3UZD5
canonical
ensembl
ENSMUSG00000069378
resolver
ensp
ENSMUSP00000089513
resolver
ensp
ENSMUSP00000230998
resolver
genesymbol
Prdm6
resolver
genesymbol_syn
Gm92
resolver
genesymbol_syn
Prism
resolver
uniprot
B9EIB0
resolver
uniprot
Q2I2X0
resolver
uniprot
Q2I2X1
resolver
uniprot
Q3UX75
resolver
uniprot_entry
PRDM6_MOUSE
resolver
uniprot_sec
B9EIB0
resolver
uniprot_sec
Q2I2X0
resolver
uniprot_sec
Q2I2X1
resolver
uniprot_sec
Q3UX75
resolver
amino_acid_sequence
MLKPGDPGGSAFLKVDPAYLQHWQQLFPHGGGGGGPLKASGAALALGAPQPLQPPPPPPPPPPERAEPPPDGLRPRPASLSSTPAPSSTSASSASSCAAAAAAAALAGLSALPVAQMPVFAPLAAAAVAAEPLPPKDLCLGASAGPGPAKCGGGGGSVGDGRGVPRFRCSAEELDYYLYGQQRMEIIPLNQHTSDPNNRCDMCADNRNGECPMHGPLHSLRRLVGTSSAAAAAPPPELPEWLRDLPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLSPEKVQTGVVRNTQHLWEIYDQDGTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSFFGIPLQCIAQDENLNVPSTVMEAMCRQDALQPFNKSSKLSPSGQQRSVVFPQTPCSRNFSLLDKSGPMEAGFNQINVKNQRVLASPTSTSQLHSEFSDWHLWKCGQCFKTFTQRILLQMHVCTQNPDRPYQCGHCSQSFSQPSELRNHVVTHSSDRPFKCGYCGRAFAGATTLNNHIRTHTGEKPFKCERCERSFTQATQLSRHQRMPNECKPITESPESIEVD
uniprot
proteins
ec_number
2.1.1.361
uniprot
proteins
function
FUNCTION: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression (PubMed:16537907, PubMed:17662997). Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells (PubMed:16537907, PubMed:17662997, PubMed:27181681). Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a (PubMed:16537907). According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (PubMed:17662997). {ECO:0000269|PubMed:16537907, ECO:0000269|PubMed:17662997, ECO:0000269|PubMed:27181681}.
uniprot
proteins
mass_dalton
64503
uniprot
proteins
mutagenesis
MUTAGEN 264; /note="C->S: Loss of function in histone modification."; /evidence="ECO:0000269|PubMed:27181681"; MUTAGEN 550; /note="R->Q: Loss of function in histone modification. Loss of nuclear localization."; /evidence="ECO:0000269|PubMed:27181681
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16537907
uniprot
proteins
pubmed
17662997
uniprot
proteins
pubmed
27181681
uniprot
proteins
sequence_length
596
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16537907, ECO:0000269|PubMed:17662997, ECO:0000269|PubMed:27181681}.
uniprot
proteins