Ist1
entrez
307833
canonical
uniprot
Q568Z6
canonical
ensembl
ENSRNOG00000015144
resolver
ensembl
ENSRNOG00055021290
resolver
ensembl
ENSRNOG00060012019
resolver
ensembl
ENSRNOG00065011565
resolver
ensp
ENSRNOP00000020365
resolver
ensp
ENSRNOP00055029576
resolver
ensp
ENSRNOP00060016051
resolver
ensp
ENSRNOP00065014379
resolver
enst
ENSRNOT00000020365
resolver
enst
ENSRNOT00055036385
resolver
enst
ENSRNOT00060020393
resolver
enst
ENSRNOT00065018807
resolver
genesymbol
Ist1
resolver
uniprot_entry
IST1_RAT
resolver
amino_acid_sequence
MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPDSVVMAEAPVGVETDLIDVGFTDDVKKGGPGRGGGGGFTAPVGAPDGTMPMPMPMPMPMPSPSPNAPFAYPLPKGPSDFSGLPVGTYQAFPNIHPPQIPATPPSYESVDDINADKNVSSAQIVGPKPEAPAKPPSRPVDNYNTFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT
uniprot
proteins
function
FUNCTION: ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (By similarity). Is required for efficient abscission during cytokinesis (By similarity). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (By similarity). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (By similarity). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (By similarity). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (By similarity). {ECO:0000250|UniProtKB:P53990}.
uniprot
proteins
mass_dalton
39942
uniprot
proteins
protein_family
IST1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250|UniProtKB:P53990}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P53990}. Midbody {ECO:0000250|UniProtKB:P53990}. Nucleus envelope {ECO:0000250|UniProtKB:P53990}. Note=Localizes to centrosome and midbody of dividing cells. Colocalized with SPART to the ends of Flemming bodies during cytokinesis. Localizes to the reforming nuclear envelope on chromatin disks during late anaphase. {ECO:0000250|UniProtKB:P53990}.
uniprot
proteins