Cd27
entrez
21940
canonical
uniprot
P41272
canonical
ensembl
ENSMUSG00000030336
resolver
ensp
ENSMUSP00000032486
resolver
ensp
ENSMUSP00000107900
resolver
ensp
ENSMUSP00000107901
resolver
enst
ENSMUST00000032486
resolver
enst
ENSMUST00000112281
resolver
enst
ENSMUST00000112282
resolver
genesymbol
Cd27
resolver
genesymbol_syn
Tnfrsf7
resolver
uniprot
B7ZW87
resolver
uniprot
D3Z7W5
resolver
uniprot
F6S3E6
resolver
uniprot
Q3U4X0
resolver
uniprot_entry
B7ZW87_MOUSE
resolver
uniprot_entry
CD27_MOUSE
resolver
uniprot_entry
D3Z7W5_MOUSE
resolver
uniprot_entry
F6S3E6_MOUSE
resolver
uniprot_entry
Q3U4X0_MOUSE
resolver
amino_acid_sequence
MAWPPPYWLCMLGTLVGLSATLAPNSCPDKHYWTGGGLCCRMCEPGTFFVKDCEQDRTAAQCDPCIPGTSFSPDYHTRPHCESCRHCNSGFLIRNCTVTANAECSCSKNWQCRDQECTECDPPLNPALTRQPSETPSPQPPPTHLPHGTEKPSWPLHRQLPNSTVYSQRSSHRPLCSSDCIRIFVTFSSMFLIFVLGAILFFHQRRNHGPNEDRQAVPEEPCPYSCPREEEGSAIPIQEDYRKPEPAFYP
uniprot
proteins
function
FUNCTION: Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells (PubMed:11062504). Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory (By similarity). In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis (PubMed:15723067). Negatively regulates the function of Th2 lymphocytes in the adipose tissue (PubMed:38386557). {ECO:0000250|UniProtKB:P26842, ECO:0000269|PubMed:11062504, ECO:0000269|PubMed:15723067, ECO:0000269|PubMed:38386557}.
uniprot
proteins
mass_dalton
28164
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:P26842}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:P26842}.; PTM: O-glycosylated with core 1 or possibly core 8 glycans. {ECO:0000250|UniProtKB:P26842}.
uniprot
proteins
pubmed
11062504
uniprot
proteins
pubmed
15723067
uniprot
proteins
pubmed
38386557
uniprot
proteins
pubmed
8384562
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P26842}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins