Frmd8
entrez
309172
canonical
uniprot
Q5U2R3
canonical
ensembl
ENSRNOG00000020881
resolver
ensembl
ENSRNOG00055021816
resolver
ensembl
ENSRNOG00060031878
resolver
ensembl
ENSRNOG00065033898
resolver
ensp
ENSRNOP00000095691
resolver
ensp
ENSRNOP00055030504
resolver
ensp
ENSRNOP00060045742
resolver
ensp
ENSRNOP00065047881
resolver
enst
ENSRNOT00000113145
resolver
enst
ENSRNOT00055037420
resolver
enst
ENSRNOT00060055298
resolver
enst
ENSRNOT00065058204
resolver
genesymbol
Frmd8
resolver
uniprot_entry
FRMD8_RAT
resolver
amino_acid_sequence
MEGAEGNAGQPGPAERSHRSSVSSVGARAADVLVYLADDTVVPLAVENLSSISAHELHRAVREVLQLPDMALEAFALWLVSPLLEVQLKPKHQPYKLGRQWPELLLRFTDASDDDIAMDEPSLQFRRNVFFPKRRELQVHDEEVLRLLYEEAKGNVLTARYPCDLEDCEVLGGLVCRVQLGPYQPGQPAACTVREKLDSFLPAHLCKRGHGLFAAFRGRGAKTGPCEQGLLNAYRQVKEMAGGDSERETTLGSHYRAYLLKCHELPFYGCAFFHGEVDKPTQGFLHRGGRKPVTVAISLEGVHVIDNREKHVLLGLRFQELSWDHTSPEEEEPVLWLEFDGDSEGTPVNKLLRIYSKQAELMSVLIEYCIELSQAAEPALPQESASGPQEAPSPSSAPTQRPKLRRQGSVVCSRIQHLSTIDYVEDGSGIKRVKPKRTTSFFSRQLSSSHGSYTVVQPNDNSPEQG
uniprot
proteins
function
FUNCTION: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity). {ECO:0000250|UniProtKB:Q9BZ67}.
uniprot
proteins
mass_dalton
51782
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BZ67}. Cell membrane {ECO:0000250|UniProtKB:Q9BZ67}.
uniprot
proteins