THEMIS
entrez
387357
canonical
uniprot
Q8N1K5
canonical
ensembl
ENSG00000172673
resolver
ensembl
ENSG00000275122
resolver
ensp
ENSP00000357231
resolver
ensp
ENSP00000439863
resolver
ensp
ENSP00000487358
resolver
ensp
ENSP00000522216
resolver
genesymbol
THEMIS
resolver
genesymbol_syn
C6orf190
resolver
genesymbol_syn
C6orf207
resolver
hgnc
HGNC:21569
resolver
uniprot
A1L4F0
resolver
uniprot
A8K7N1
resolver
uniprot
B3KT31
resolver
uniprot
B3KW32
resolver
uniprot
B3KY07
resolver
uniprot
F5H1J9
resolver
uniprot
Q5T3C4
resolver
uniprot
Q5T3C5
resolver
uniprot
Q6MZT7
resolver
uniprot_entry
THMS1_HUMAN
resolver
uniprot_sec
A1L4F0
resolver
uniprot_sec
A8K7N1
resolver
uniprot_sec
B3KT31
resolver
uniprot_sec
B3KW32
resolver
uniprot_sec
B3KY07
resolver
uniprot_sec
F5H1J9
resolver
uniprot_sec
Q5T3C4
resolver
uniprot_sec
Q5T3C5
resolver
uniprot_sec
Q6MZT7
resolver
amino_acid_sequence
MALSLEEFVHSLDLRTLPRVLEIQAGIYLEGSIYEMFGNECCFSTGEVIKITGLKVKKIIAEICEQIEGCESLQPFELPMNFPGLFKIVADKTPYLTMEEITRTIHIGPSRLGHPCFYHQKDIKLENLIIKQGEQIMLNSVEEIDGEIMVSCAVARNHQTHSFNLPLSQEGEFYECEDERIYTLKEIVEWKIPKNRTRTVNLTDFSNKWDSTNPFPKDFYGTLILKPVYEIQGVMKFRKDIIRILPSLDVEVKDITDSYDANWFLQLLSTEDLFEMTSKEFPIVTEVIEAPEGNHLPQSILQPGKTIVIHKKYQASRILASEIRSNFPKRHFLIPTSYKGKFKRRPREFPTAYDLEIAKSEKEPLHVVATKAFHSPHDKLSSVSVGDQFLVHQSETTEVLCEGIKKVVNVLACEKILKKSYEAALLPLYMEGGFVEVIHDKKQYPISELCKQFRLPFNVKVSVRDLSIEEDVLAATPGLQLEEDITDSYLLISDFANPTECWEIPVGRLNMTVQLVSNFSRDAEPFLVRTLVEEITEEQYYMMRRYESSASHPPPRPPKHPSVEETKLTLLTLAEERTVDLPKSPKRHHVDITKKLHPNQAGLDSKVLIGSQNDLVDEEKERSNRGATAIAETFKNEKHQK
uniprot
proteins
function
FUNCTION: Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. {ECO:0000250|UniProtKB:Q8BGW0}.
uniprot
proteins
mass_dalton
73452
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr residues quickly after TCR stimulation. {ECO:0000250|UniProtKB:Q8BGW0}.
uniprot
proteins
protein_family
Themis family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19690332
uniprot
proteins
sequence_length
641
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BGW0}. Nucleus {ECO:0000250|UniProtKB:Q8BGW0}.
uniprot
proteins