Capg
entrez
297339
canonical
uniprot
Q6AYC4
canonical
ensembl
ENSRNOG00000013668
resolver
ensp
ENSRNOP00000018562
resolver
ensp
ENSRNOP00000087979
resolver
enst
ENSRNOT00000018562
resolver
genesymbol
Capg
resolver
uniprot
A0A8L2Q9I9
resolver
uniprot_entry
A0A8L2Q9I9_RAT
resolver
uniprot_entry
CAPG_RAT
resolver
amino_acid_sequence
MYTPIPQSGSPFPASVQDPGLHIWRVEKLKPVPIARENHGIFFSGDSYLVLHNGPEEASHLHLWIGQQSSRDEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPQGLKYREGGVESAFHKTTSGTTPAAIRKLYQVKGKKNIRATERALSWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKAQVEIITDGEEPAEMIQVLGPKPALKEGNPEEDITADQTNAQAAALYKVSDATGQMNLTKVADSSPFASELLIPDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVADGFISRMRYSPNTQVEILPQGRESPIFKQFFKDWK
uniprot
proteins
function
FUNCTION: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. Uncapping occurs either when Ca(2+) falls or when the concentration of polyphosphoinositide rises, both at low and high Ca(2+) (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
38799
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
Villin/gelsolin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P24452}. Cytoplasm {ECO:0000250|UniProtKB:P24452}. Melanosome {ECO:0000250|UniProtKB:P40121}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P24452}. Cell projection, ruffle {ECO:0000250|UniProtKB:P24452}. Note=In macrophages, may be predominantly cytoplasmic. Nuclear localization was observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated in the ruffles of the leading lamellipodia. {ECO:0000250|UniProtKB:P24452}.
uniprot
proteins