Tm7sf2
entrez
73166
canonical
uniprot
Q71KT5
canonical
ensembl
ENSMUSG00000024799
resolver
ensp
ENSMUSP00000025713
resolver
ensp
ENSMUSP00000123989
resolver
enst
ENSMUST00000025713
resolver
enst
ENSMUST00000161528
resolver
genesymbol
Tm7sf2
resolver
uniprot
B5LBK0
resolver
uniprot
F6XXB2
resolver
uniprot
Q3V3I6
resolver
uniprot_entry
ERG24_MOUSE
resolver
uniprot_entry
F6XXB2_MOUSE
resolver
uniprot_entry
Q3V3I6_MOUSE
resolver
uniprot_sec
B5LBK0
resolver
amino_acid_sequence
MTSREASQAPLEFGGPLGVAALLILLPATMFHLLLAARSGPARLLALPAYLPGLEELWSPWALLLLFIWLGLQVALYLLPARKVAEGLELKDKSRLRYPINGFQALVLTALLMGLGVSVGLPLGALPGMLLPLAFATTLTSFIFSLLLYAKALVAPASALAPGGNSGNSMYDFFLGRELNPRLGSFDFKYFCELRPGLIGWVFINLALLMQEAELRGSPSLAMWLVNGFQLLYVGDALWYEESVLTTMDIIHDGFGFMLVFGDLAWVPFTYSLQAQFLLYHPQPLGLPMALLICLLKVIGYYIFRGANSQKNTFRKNPSDPSVAGLETIPTATGRQLLVSGWWGMVRHPNYLGDLIMALAWSLPCGLSHLLPYFYVLYFTALLVHREARDEQQCLQKYGRAWQEYCKRVPYRIIPYVY
uniprot
proteins
ec_number
1.3.1.70
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. {ECO:0000269|PubMed:18785926}.
uniprot
proteins
mass_dalton
46521
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; cholesterol biosynthesis.
uniprot
proteins
protein_family
ERG4/ERG24 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18785926
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O76062}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000269|PubMed:18785926}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..35; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..81; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 102..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 129..148; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 255..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 287..304; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 355..377; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins