Hpgds
entrez
54486
canonical
uniprot
Q9JHF7
canonical
ensembl
ENSMUSG00000029919
resolver
ensp
ENSMUSP00000031982
resolver
ensp
ENSMUSP00000250238
resolver
ensp
ENSMUSP00000250244
resolver
enst
ENSMUST00000031982
resolver
genesymbol
Hpgds
resolver
genesymbol_syn
Gsts
resolver
genesymbol_syn
Pgds
resolver
genesymbol_syn
Ptgds2
resolver
uniprot
Q14AR4
resolver
uniprot
Q8CA80
resolver
uniprot_entry
HPGDS_MOUSE
resolver
uniprot_sec
Q14AR4
resolver
uniprot_sec
Q8CA80
resolver
amino_acid_sequence
MPNYKLLYFNMRGRAEIIRYIFAYLDIKYEDHRIEQADWPKIKPTLPFGKIPVLEVEGLTIHQSLAIARYLTKNTDLAGKTALEQCQADAVVDTLDDFMSLFPWAEKDQDLKERMFNELLTHQAPRLLKDLDTYLGDKEWFIGNYVTWADFYWDICSTTLLVLKPGLLDIYPKLVSLRNKVQAIPAISAWILKRPQTKL
uniprot
proteins
ec_number
2.5.1.18
uniprot
proteins
ec_number
5.3.99.2
uniprot
proteins
function
FUNCTION: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates (PubMed:10824118, PubMed:16547010). Similarly, catalyzes the conversion of PGH3 (derived from eicosapentaenoate (EPA, C20:5n-3)) to PGD3, though PGH2 remains the preferred substrate. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide (By similarity). {ECO:0000250|UniProtKB:O60760, ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:16547010}.
uniprot
proteins
mass_dalton
23227
uniprot
proteins
protein_family
GST superfamily
uniprot
proteins
protein_family
Sigma family
uniprot
proteins
pubmed
10824118
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16547010
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins