Pnrc2
entrez
52830
canonical
uniprot
Q9CR73
canonical
ensembl
ENSMUSG00000028675
resolver
ensp
ENSMUSP00000030436
resolver
enst
ENSMUST00000030436
resolver
genesymbol
Pnrc2
resolver
uniprot
B1AV48
resolver
uniprot
B1AV49
resolver
uniprot
Q9CXC6
resolver
uniprot_entry
PNRC2_MOUSE
resolver
uniprot_sec
B1AV48
resolver
uniprot_sec
B1AV49
resolver
uniprot_sec
Q9CXC6
resolver
amino_acid_sequence
MGGGERYNIPDPQSRNASKNQEQQNRQKSKDQNSSQTKIAHKKKERGHGYNPAAAAWQAMQNGGKTKSLSNNSNWNAGLSSPSLLFKSQASQNYAGAKFSEPPSPSVLPKPPSHWVHVSLNPSDKETMTFQLKTLLKVQV
uniprot
proteins
function
FUNCTION: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (By similarity). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (By similarity). Required for UPF1/RENT1 localization to the P-body (By similarity). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure (PubMed:17971453). {ECO:0000250|UniProtKB:Q9NPJ4, ECO:0000269|PubMed:17971453}.
uniprot
proteins
mass_dalton
15401
uniprot
proteins
protein_family
PNRC family
uniprot
proteins
protein_family
PNRC2 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16181749
uniprot
proteins
pubmed
17971453
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
140
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}.
uniprot
proteins