HYAL3
entrez
8372
canonical
uniprot
O43820
canonical
ensembl
ENSG00000186792
resolver
ensp
ENSP00000337425
resolver
ensp
ENSP00000391922
resolver
ensp
ENSP00000401092
resolver
ensp
ENSP00000424633
resolver
ensp
ENSP00000479935
resolver
genesymbol
HYAL3
resolver
genesymbol_syn
LUCA3
resolver
hgnc
HGNC:5322
resolver
uniprot
O60540
resolver
uniprot
Q8NFK2
resolver
uniprot
Q8NFK3
resolver
uniprot
Q8NFK4
resolver
uniprot
Q96E56
resolver
uniprot
Q9BRW9
resolver
uniprot_entry
HYAL3_HUMAN
resolver
uniprot_sec
O60540
resolver
uniprot_sec
Q8NFK2
resolver
uniprot_sec
Q8NFK3
resolver
uniprot_sec
Q8NFK4
resolver
uniprot_sec
Q96E56
resolver
uniprot_sec
Q9BRW9
resolver
amino_acid_sequence
MTTQLGPALVLGVALCLGCGQPLPQVPERPFSVLWNVPSAHCEARFGVHLPLNALGIIANRGQHFHGQNMTIFYKNQLGLYPYFGPRGTAHNGGIPQALPLDRHLALAAYQIHHSLRPGFAGPAVLDWEEWCPLWAGNWGRRRAYQAASWAWAQQVFPDLDPQEQLYKAYTGFEQAARALMEDTLRVAQALRPHGLWGFYHYPACGNGWHSMASNYTGRCHAATLARNTQLHWLWAASSALFPSIYLPPRLPPAHHQAFVRHRLEEAFRVALVGHRHPLPVLAYVRLTHRRSGRFLSQDDLVQSIGVSAALGAAGVVLWGDLSLSSSEEECWHLHDYLVDTLGPYVINVTRAAMACSHQRCHGHGRCARRDPGQMEAFLHLWPDGSLGDWKSFSCHCYWGWAGPTCQEPRPGPKEAV
uniprot
proteins
ec_number
3.2.1.35
uniprot
proteins
function
FUNCTION: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro. {ECO:0000250|UniProtKB:Q8VEI3}.
uniprot
proteins
mass_dalton
46501
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q8VEI3}.
uniprot
proteins
protein_family
Glycosyl hydrolase 56 family
uniprot
proteins
pubmed
10493834
uniprot
proteins
pubmed
12084718
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
20586096
uniprot
proteins
pubmed
21699545
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8VEI3}. Cell membrane {ECO:0000250|UniProtKB:Q8VEI3}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8VEI3}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8VEI3}. Early endosome {ECO:0000250|UniProtKB:Q8VEI3}. Note=Mostly present in low-density vesicles. Low levels in higher density vesicles of late endosomes and lysosomes. Localized in punctate cytoplasmic vesicles and in perinuclear structures, but does not colocalize with LAMP1. Localized on the plasma membrane over the acrosome and on the surface of the midpiece of the sperm tail. {ECO:0000250|UniProtKB:Q8VEI3}.
uniprot
proteins