CD83
entrez
9308
canonical
uniprot
Q01151
canonical
ensembl
ENSG00000112149
resolver
ensp
ENSP00000368450
resolver
ensp
ENSP00000480760
resolver
ensp
ENSP00000527203
resolver
enst
ENST00000379153
resolver
enst
ENST00000612003
resolver
genesymbol
CD83
resolver
hgnc
HGNC:1703
resolver
uniprot
A0A087WX61
resolver
uniprot
Q5THX9
resolver
uniprot_entry
A0A087WX61_HUMAN
resolver
uniprot_entry
CD83_HUMAN
resolver
uniprot_sec
Q5THX9
resolver
amino_acid_sequence
MSRGLQLLLLSCAYSLAPATPEVKVACSEDVDLPCTAPWDPQVPYTVSWVKLLEGGEERMETPQEDHLRGQHYHQKGQNGSFDAPNERPYSLKIRNTTSCNSGTYRCTLQDPDGQRNLSGKVILRVTGCPAQRKEETFKKYRAEIVLLLALVIFYLTLIIFTCKFARLQSIFPDFSKAGMERAFLPVTSPNKHLGLVTPHKTELV
uniprot
proteins
function
FUNCTION: Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation (PubMed:21220452). In addition, acts as an important modulator of protective responses against acute infections (By similarity). {ECO:0000250|UniProtKB:O88324, ECO:0000269|PubMed:21220452}.
uniprot
proteins
mass_dalton
23042
uniprot
proteins
post_translational_modification
PTM: Glycosylated when expressed on activated dendritic cells. {ECO:0000269|PubMed:11922761}.
uniprot
proteins
pubmed
11922761
uniprot
proteins
pubmed
1378080
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21220452
uniprot
proteins
pubmed
28315353
uniprot
proteins
pubmed
8422464
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 145..166; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins