DTWD2
entrez
285605
canonical
uniprot
Q8NBA8
canonical
ensembl
ENSG00000169570
resolver
ensp
ENSP00000302892
resolver
ensp
ENSP00000425048
resolver
ensp
ENSP00000554923
resolver
genesymbol
DTWD2
resolver
hgnc
HGNC:19334
resolver
uniprot
J3KND6
resolver
uniprot_entry
DTWD2_HUMAN
resolver
uniprot_sec
J3KND6
resolver
amino_acid_sequence
MESQKEARTLQEPVARPSGASSSQTPNDKERREGGAVPAAAALGAEADDDSADGLWELPVEPAERRPECTRCSRPQKVCLCPFLPAHPLHISTHLYIIQHPAEENKVLRTVPLLAACLPQDKCKVKIGRRFSEERDPELSTVCRKSGTLILYPGAEAANLEEFILDSPVYPSTIIIIDGTWSQAKDIFYKNSLFRHPKQVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPLQALCSFQLQHGAQIRLSKEHLLKNGLYPKPMPKNKRKLRKMELLMNSVKI
uniprot
proteins
ec_number
2.5.1.25
uniprot
proteins
function
FUNCTION: Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)) (PubMed:31804502, PubMed:39173631). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)) (PubMed:31804502). Involved in glycoRNA biosynthesis by mediating formation of acp3U, which acts as an attachment site for N-glycans on tRNAs (PubMed:39173631). GlycoRNAs consist of RNAs modified with secretory N-glycans that are presented on the cell surface (PubMed:39173631). {ECO:0000269|PubMed:31804502, ECO:0000269|PubMed:39173631}.
uniprot
proteins
mass_dalton
33416
uniprot
proteins
protein_family
DTWD2 family
uniprot
proteins
protein_family
TDD superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
31804502
uniprot
proteins
pubmed
39173631
uniprot
proteins
sequence_length
298
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:31804502}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:31804502}. Cytoplasm {ECO:0000269|PubMed:31804502}. Note=Localizes mainly in the nucleus. {ECO:0000269|PubMed:31804502}.
uniprot
proteins