Hsd17b3
entrez
15487
canonical
uniprot
P70385
canonical
ensembl
ENSMUSG00000033122
resolver
ensp
ENSMUSP00000132011
resolver
ensp
ENSMUSP00000152848
resolver
enst
ENSMUST00000166224
resolver
enst
ENSMUST00000222783
resolver
genesymbol
Hsd17b3
resolver
genesymbol_syn
Edh17b3
resolver
uniprot
G3UWF9
resolver
uniprot_entry
DHB3_MOUSE
resolver
uniprot_sec
G3UWF9
resolver
amino_acid_sequence
MEKLFIAAGLFVGLVCLVKCMRFSQHLFLRFCKALPSSFLRSMGQWAVITGAGDGIGKAYSFELARHGLNVVLISRTLEKLQTIAEEIERTTGSCVKIVQADFTREDIYDHIKEHLEGLEIGILVNNVGMLPSFFPSHFLSTSGESQNLIHCNITSVVKMTQLVLKHMESRRKGLILNISSGAALRPWPLYSLYSASKAFVYTFSKALSVEYRDKGIIIQVLTPYSISTPMTKYLNNKMTKTADEFVKESLKYVTIGAESCGCLAHEIIAIILNRIPSRIFYSSTAQRFLLTRYSDYLKRNISNR
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
ec_number
1.1.1.64
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids (PubMed:32557858). Favors the reduction of androstenedione to testosterone (PubMed:32557858). Testosterone is the key androgen driving male development and function (PubMed:32190925, PubMed:32557858). Uses NADPH while the two other EDH17B enzymes use NADH (By similarity). Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (By similarity). Plays a role in the rate-limiting-step for the maximum level of testosterone production by the testis but does not affect basal testosterone production (PubMed:32190925, PubMed:32557858). {ECO:0000250|UniProtKB:P37058, ECO:0000269|PubMed:32190925, ECO:0000269|PubMed:32557858, ECO:0000303|PubMed:32190925, ECO:0000303|PubMed:32557858}.
uniprot
proteins
mass_dalton
34330
uniprot
proteins
pathway_participation
PATHWAY: Hormone biosynthesis; testosterone biosynthesis. {ECO:0000269|PubMed:32190925, ECO:0000269|PubMed:32557858}.; PATHWAY: Steroid metabolism. {ECO:0000269|PubMed:32190925, ECO:0000269|PubMed:32557858}.
uniprot
proteins
protein_family
17-beta-HSD 3 subfamily
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
32190925
uniprot
proteins
pubmed
32557858
uniprot
proteins
pubmed
9182854
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:P37058}.
uniprot
proteins