Kcnc2
entrez
268345
canonical
uniprot
Q14B80
canonical
ensembl
ENSMUSG00000035681
resolver
ensp
ENSMUSP00000089814
resolver
ensp
ENSMUSP00000151579
resolver
ensp
ENSMUSP00000192431
resolver
ensp
ENSMUSP00000192432
resolver
ensp
ENSMUSP00000192436
resolver
ensp
ENSMUSP00000192437
resolver
ensp
ENSMUSP00000192438
resolver
ensp
ENSMUSP00000192441
resolver
enst
ENSMUST00000092175
resolver
enst
ENSMUST00000219301
resolver
genesymbol
Kcnc2
resolver
uniprot
A0A1W2P796
resolver
uniprot_entry
A0A1W2P796_MOUSE
resolver
uniprot_entry
KCNC2_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by millimolar levels of tetraethylammonium (TEA). Contrary to other channels, inhibited only by millimolar levels of 4-aminopyridine (4-AP). Inhibited by Stichodactyla helianthus peptide ShK. {ECO:0000250|UniProtKB:P22462, ECO:0000250|UniProtKB:Q96PR1, ECO:0000305|PubMed:10414303}.
uniprot
proteins
amino_acid_sequence
MGKIESNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPQGDCLTAAGDKLQPLPPPLSPPPRPPPLSPVPSGCFEGGAGNCSSHGGNGGNGGSDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRKLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSPVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPLASSPTFCKTELNMACNSTQSDTCLGKENRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTCASDGGIRKGYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL
uniprot
proteins
function
FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system (PubMed:10414303, PubMed:10561420, PubMed:10903572, PubMed:11124984, PubMed:11506885, PubMed:15317859, PubMed:15917463, PubMed:17761775, PubMed:21414897). Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly (PubMed:10414303, PubMed:10561420, PubMed:10903572, PubMed:15317859). Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (By similarity). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:10531438, PubMed:12000114). Channel properties may be modulated by either the association with ancillary subunits, such as KCNE1, KCNE2 and KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in thalamocortical and suprachiasmatic nucleus (SCN) neurons, in hippocampal and neocortical interneurons and in retinal ganglion cells (PubMed:10561420, PubMed:10903572, PubMed:11506885, PubMed:17761775). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner (PubMed:10903572). Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release (PubMed:15917463). Required for long-range synchronization of gamma oscillations over distance in the neocortex (PubMed:22539821). Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (PubMed:21414897). {ECO:0000250|UniProtKB:P22462, ECO:0000269|PubMed:10531438, ECO:0000269|PubMed:10561420, ECO:0000269|PubMed:10903572, ECO:0000269|PubMed:11124984, ECO:0000269|PubMed:12000114, ECO:0000269|PubMed:15317859, ECO:0000269|PubMed:15917463, ECO:0000269|PubMed:17761775, ECO:0000269|PubMed:21414897, ECO:0000269|PubMed:22539821, ECO:0000305|PubMed:10414303, ECO:0000305|PubMed:11506885}.
uniprot
proteins
mass_dalton
70503
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA in cortical synaptosomes. cAMP-dependent phosphorylation inhibits channel activity (By similarity). Histamine H2 receptor- and PKA-induced phosphorylation extends action potential spike duration, reduces action potential spike amplitude, sustains maximum firing frequency in hippocampal interneurons; also reduces the incidence of high-frequency oscillations in hippocampal CA3 pyramidal cell layers (PubMed:10903572). {ECO:0000250|UniProtKB:P63142, ECO:0000269|PubMed:10903572}.
uniprot
proteins
protein_family
C (Shaw) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv3.2/KCNC2 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10414303
uniprot
proteins
pubmed
10531438
uniprot
proteins
pubmed
10561420
uniprot
proteins
pubmed
10903572
uniprot
proteins
pubmed
11124984
uniprot
proteins
pubmed
11506885
uniprot
proteins
pubmed
12000114
uniprot
proteins
pubmed
15317859
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15852012
uniprot
proteins
pubmed
15917463
uniprot
proteins
pubmed
17761775
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21414897
uniprot
proteins
pubmed
21912965
uniprot
proteins
pubmed
22539821
uniprot
proteins
sequence_length
642
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10531438, ECO:0000269|PubMed:11124984, ECO:0000269|PubMed:15317859, ECO:0000269|PubMed:17761775, ECO:0000269|PubMed:21414897, ECO:0000269|PubMed:22539821}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000269|PubMed:12000114}; Multi-pass membrane protein {ECO:0000255}. Perikaryon {ECO:0000269|PubMed:10531438, ECO:0000269|PubMed:10903572, ECO:0000269|PubMed:12000114, ECO:0000269|PubMed:15317859, ECO:0000269|PubMed:15852012}. Cell projection, axon {ECO:0000269|PubMed:10531438, ECO:0000269|PubMed:10903572}. Cell projection, dendrite {ECO:0000269|PubMed:10531438, ECO:0000269|PubMed:10903572, ECO:0000269|PubMed:12000114, ECO:0000269|PubMed:15317859}. Postsynaptic cell membrane {ECO:0000269|PubMed:10531438}. Presynaptic cell membrane {ECO:0000269|PubMed:10531438}. Synapse, synaptosome {ECO:0000250|UniProtKB:P22462}. Synapse {ECO:0000250|UniProtKB:P22462}. Apical cell membrane {ECO:0000250|UniProtKB:P22462}. Basolateral cell membrane {ECO:0000250|UniProtKB:P22462}. Note=Colocalizes with parvalbumin in globus pallidus neurons. Localizes in thalamocortical axons and synapses (By similarity). Localizes on the surface of cell somata, proximal dendrites and axonal membranes (PubMed:10903572, PubMed:12000114). Also detected throughout the neuropil (PubMed:12000114). Localized in starburst cell somata and proximal dendrite processes (PubMed:15317859). Colocalized with GABA in presynaptic terminals (PubMed:10531438). Clustered in patches in somatic and proximal dendritic membrane as well as in axons and presnypatic terminals of GABAergic interneurons; some of these patches are found near postsynaptic sites (PubMed:10531438). {ECO:0000250|UniProtKB:P22462, ECO:0000269|PubMed:10531438, ECO:0000269|PubMed:10903572, ECO:0000269|PubMed:12000114, ECO:0000269|PubMed:15317859}.
uniprot
proteins
transmembrane_region
TRANSMEM 234..254; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 287..307; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 318..338; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 350..372; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 386..406; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 457..477; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins