Ccdc120
entrez
54648
canonical
uniprot
A2AEV7
canonical
ensembl
ENSMUSG00000031150
resolver
ensp
ENSMUSP00000033490
resolver
enst
ENSMUST00000033490
resolver
genesymbol
Ccdc120
resolver
uniprot
A2AEV8
resolver
uniprot_entry
CC120_MOUSE
resolver
uniprot_sec
A2AEV8
resolver
amino_acid_sequence
MEVKGQLISSPTFTAPAALFGEAAPLVKSDRLRGLLDRQRALQEALSVKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPAARAYPPPHPNPAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLNGEQRRRRRQVQVDALRRLHELEEQLRDFRARLGLPVLQPLPLSAGALVNAQGVCLGTRLAQLSQEDVVLHSESSSLSESGASHDNEEPHSCFPLTERPSPPKAWDQFRAVSGGSPERRAPWKPPPSDIYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGSGPRLCKPEGLHSRQWSGSQDSQMGFPRPDPASDRASLFAARTRRSNSSEALLVDRAAAGGAGSPPAPLAPPAAGPPVCKSSEVLYERPQPVPSFSSRTTGPPDPPRAARPSSAAPASRGAPRLPTVCGDFLLDYPLDRGLPRGSGGAGWGELLPAPEVPGPLSRRDGLLAMLPGPPPIYAADGSSPLLRSKDPNTRAIRSKPSGLPPEAVEGLEVHPNPLLWMPPPTRIPPAGERGGHKNLALEGLRDWYIRNSGLAVGPQRRPMLPHVGPTHTPFLHARCYEVGQSLYGPPSQAPLPHSRSFTAPPVSGRYGGAFTDG
uniprot
proteins
function
FUNCTION: Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth (By similarity). Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth (By similarity). {ECO:0000250|UniProtKB:Q96HB5, ECO:0000269|PubMed:28422092}.
uniprot
proteins
mass_dalton
67407
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; interaction with CYTH2 may prevent ubiquitination. {ECO:0000250|UniProtKB:Q96HB5}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
28422092
uniprot
proteins
sequence_length
629
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q96HB5}. Cytoplasm {ECO:0000250|UniProtKB:Q96HB5}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q96HB5}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q96HB5}. Endosome {ECO:0000250|UniProtKB:Q96HB5}. Note=Localizes to the subdistal appendages of mother centrioles and proximal ends of both centrioles in interphase cells (By similarity). Recruited to subdistal appendages by ODF2 (By similarity). In differentiating neuroblastoma cells, colocalizes with CYTH2 in both neurite shaft and growth cone areas (By similarity). Partially colocalizes with endosomes along neurites in differentiating neuroblastoma cells (By similarity). {ECO:0000250|UniProtKB:Q96HB5}.
uniprot
proteins