SELL
entrez
6402
canonical
uniprot
P14151
canonical
ensembl
ENSG00000188404
resolver
ensp
ENSP00000236147
resolver
genesymbol
SELL
resolver
genesymbol_syn
LNHR
resolver
genesymbol_syn
LYAM1
resolver
hgnc
HGNC:10720
resolver
uniprot
A0A024R8Z0
resolver
uniprot
B2R6Q8
resolver
uniprot
P15023
resolver
uniprot
Q9UJ43
resolver
uniprot_entry
LYAM1_HUMAN
resolver
uniprot_sec
A0A024R8Z0
resolver
uniprot_sec
B2R6Q8
resolver
uniprot_sec
P15023
resolver
uniprot_sec
Q9UJ43
resolver
amino_acid_sequence
MIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGKKSKRSMNDPY
uniprot
proteins
function
FUNCTION: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28011641, PubMed:28489325). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641). {ECO:0000269|PubMed:12403782, ECO:0000269|PubMed:28011641, ECO:0000305|PubMed:28489325}.
uniprot
proteins
mass_dalton
42187
uniprot
proteins
mutagenesis
MUTAGEN 60; /note="N->Q: Loss of one glycosylation site."; /evidence="ECO:0000269|PubMed:28489325"; MUTAGEN 104; /note="N->Q: Loss of one glycosylation site."; /evidence="ECO:0000269|PubMed:28489325"; MUTAGEN 126; /note="E->D: Impairs interaction with cognate oligosaccharide. Abolishes cell rolling on glycan ligands."; /evidence="ECO:0000269|PubMed:28011641"; MUTAGEN 177; /note="N->Q: Loss of one glycosylation site."; /evidence="ECO:0000269|PubMed:28489325
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:2663882, ECO:0000269|PubMed:28011641, ECO:0000269|PubMed:28489325}.
uniprot
proteins
protein_family
Selectin/LECAM family
uniprot
proteins
pubmed
12403782
uniprot
proteins
pubmed
12736247
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1692315
uniprot
proteins
pubmed
18606703
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
2473156
uniprot
proteins
pubmed
2509939
uniprot
proteins
pubmed
2663882
uniprot
proteins
pubmed
2664786
uniprot
proteins
pubmed
28011641
uniprot
proteins
pubmed
28489325
uniprot
proteins
pubmed
7488174
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2509939, ECO:0000269|PubMed:2663882, ECO:0000269|PubMed:28011641}; Single-pass type I membrane protein {ECO:0000305|PubMed:2663882}.
uniprot
proteins
transmembrane_region
TRANSMEM 333..355; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins