COX7A2
entrez
1347
canonical
uniprot
P14406
canonical
ensembl
ENSG00000112695
resolver
ensp
ENSP00000359098
resolver
ensp
ENSP00000359106
resolver
ensp
ENSP00000506727
resolver
enst
ENST00000370081
resolver
enst
ENST00000370089
resolver
enst
ENST00000684430
resolver
genesymbol
COX7A2
resolver
genesymbol_syn
COX7AL
resolver
hgnc
HGNC:2288
resolver
uniprot
B2R5E1
resolver
uniprot
H0UI06
resolver
uniprot
H6SG16
resolver
uniprot
Q3MIH5
resolver
uniprot
Q5TF59
resolver
uniprot
Q6FGI2
resolver
uniprot_entry
CX7A2_HUMAN
resolver
uniprot_entry
H0UI06_HUMAN
resolver
uniprot_entry
H6SG16_HUMAN
resolver
uniprot_sec
B2R5E1
resolver
uniprot_sec
Q3MIH5
resolver
uniprot_sec
Q5TF59
resolver
uniprot_sec
Q6FGI2
resolver
amino_acid_sequence
MLRNLLALRQIGQRTISTASRRHFKNKVPEKQKLFQEDDEIPLYLKGGVADALLYRATMILTVGGTAYAIYELAVASFPKKQE
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P10174}.
uniprot
proteins
mass_dalton
9396
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P10174}.
uniprot
proteins
protein_family
Cytochrome c oxidase VIIa family
uniprot
proteins
pubmed
11004498
uniprot
proteins
pubmed
1309697
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22356826
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2550906
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28844695
uniprot
proteins
pubmed
30030519
uniprot
proteins
sequence_length
83
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Single-pass membrane protein {ECO:0000269|PubMed:30030519}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..77; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P07470
uniprot
proteins