GPX1
entrez
2876
canonical
uniprot
P07203
canonical
ensembl
ENSG00000233276
resolver
ensp
ENSP00000391316
resolver
ensp
ENSP00000407375
resolver
ensp
ENSP00000493593
resolver
ensp
ENSP00000495001
resolver
ensp
ENSP00000495108
resolver
ensp
ENSP00000515482
resolver
ensp
ENSP00000515880
resolver
enst
ENST00000419349
resolver
enst
ENST00000419783
resolver
enst
ENST00000643797
resolver
enst
ENST00000703797
resolver
enst
ENST00000704375
resolver
genesymbol
GPX1
resolver
hgnc
HGNC:4553
resolver
uniprot
A0A2R8Y6B6
resolver
uniprot
E9PAS1
resolver
uniprot
Q7L4Q3
resolver
uniprot
Q7Z5H1
resolver
uniprot
Q9BW12
resolver
uniprot_entry
A0A2R8Y6B6_HUMAN
resolver
uniprot_entry
GPX1_HUMAN
resolver
uniprot_entry
Q7L4Q3_HUMAN
resolver
uniprot_sec
E9PAS1
resolver
uniprot_sec
Q7Z5H1
resolver
uniprot_sec
Q9BW12
resolver
amino_acid_sequence
MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRRFQTIDIEPDIEALLSQGPSCA
uniprot
proteins
ec_number
1.11.1.12
uniprot
proteins
ec_number
1.11.1.9
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:11115402, PubMed:36608588). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:11115402, PubMed:36608588). In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway (PubMed:11115402). {ECO:0000269|PubMed:11115402, ECO:0000269|PubMed:36608588}.
uniprot
proteins
mass_dalton
22088
uniprot
proteins
post_translational_modification
PTM: During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine. {ECO:0000250|UniProtKB:P11352}.
uniprot
proteins
protein_family
Glutathione peroxidase family
uniprot
proteins
pubmed
10220143
uniprot
proteins
pubmed
11115402
uniprot
proteins
pubmed
12496980
uniprot
proteins
pubmed
15247771
uniprot
proteins
pubmed
15331559
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1556108
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2307470
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2955287
uniprot
proteins
pubmed
3658677
uniprot
proteins
pubmed
36608588
uniprot
proteins
pubmed
3697069
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P11352}. Mitochondrion {ECO:0000250|UniProtKB:P11352}.
uniprot
proteins