Tspan5
entrez
362048
canonical
uniprot
Q68VK5
canonical
ensembl
ENSRNOG00000015913
resolver
ensembl
ENSRNOG00055011108
resolver
ensembl
ENSRNOG00060025883
resolver
ensembl
ENSRNOG00065023804
resolver
ensp
ENSRNOP00000084759
resolver
ensp
ENSRNOP00000100821
resolver
ensp
ENSRNOP00055015203
resolver
ensp
ENSRNOP00060037234
resolver
ensp
ENSRNOP00065033334
resolver
enst
ENSRNOT00000111381
resolver
enst
ENSRNOT00000154137
resolver
enst
ENSRNOT00055018844
resolver
enst
ENSRNOT00060044889
resolver
enst
ENSRNOT00065040849
resolver
genesymbol
Tspan5
resolver
genesymbol_syn
Tm4sf9
resolver
uniprot
A0A8I6A2L2
resolver
uniprot
Q498N9
resolver
uniprot_entry
A0A8I6A2L2_RAT
resolver
uniprot_entry
TSN5_RAT
resolver
uniprot_sec
Q498N9
resolver
amino_acid_sequence
MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEKGVLSNISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRASW
uniprot
proteins
function
FUNCTION: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CD44. Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration. {ECO:0000250|UniProtKB:P62079}.
uniprot
proteins
mass_dalton
30337
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. {ECO:0000250|UniProtKB:P62079}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P62079}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins