Amd1
entrez
81640
canonical
uniprot
P17708
canonical
ensembl
ENSRNOG00000000585
resolver
ensp
ENSRNOP00000105391
resolver
genesymbol
Amd1
resolver
uniprot_entry
DCAM_RAT
resolver
amino_acid_sequence
MEAAHFFEGTEKLLEVWFSRQQSDASQGSGDLRTIPRSEWDVLLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDLPESRVINQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATLFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLSSPQKIDGFKRLDCQSAMFNDYNFVFTSFAKKQQQQS
uniprot
proteins
ec_number
4.1.1.50
uniprot
proteins
function
FUNCTION: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. {ECO:0000250|UniProtKB:P0DMN7}.
uniprot
proteins
mass_dalton
38137
uniprot
proteins
pathway_participation
PATHWAY: Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.
uniprot
proteins
post_translational_modification
PTM: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. {ECO:0000250|UniProtKB:P17707, ECO:0000269|PubMed:2460457}.
uniprot
proteins
protein_family
Eukaryotic AdoMetDC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1936275
uniprot
proteins
pubmed
2323572
uniprot
proteins
pubmed
2460457
uniprot
proteins
pubmed
8314573
uniprot
proteins
sequence_length
333
uniprot
proteins