SOX30
entrez
11063
canonical
uniprot
O94993
canonical
ensembl
ENSG00000039600
resolver
ensp
ENSP00000265007
resolver
ensp
ENSP00000309343
resolver
ensp
ENSP00000427984
resolver
enst
ENST00000519442
resolver
genesymbol
SOX30
resolver
hgnc
HGNC:30635
resolver
uniprot
B4DXW7
resolver
uniprot
F6TCV6
resolver
uniprot
O94995
resolver
uniprot
Q8IYX6
resolver
uniprot_entry
B4DXW7_HUMAN
resolver
uniprot_entry
F6TCV6_HUMAN
resolver
uniprot_entry
SOX30_HUMAN
resolver
uniprot_sec
O94995
resolver
uniprot_sec
Q8IYX6
resolver
amino_acid_sequence
MERARPEPPPQPRPLRPAPPPLPVEGTSFWAAAMEPPPSSPTLSAAASATLASSCGEAVASGLQPAVRRLLQVKPEQVLLLPQPQAQNEEAAASSAQARLLQFRPDLRLLQPPTASDGATSRPELHPVQPLALHVKAKKQKLGPSLDQSVGPRGAVETGPRASRVVKLEGPGPALGYFRGDEKGKLEAEEVMRDSMQGGAGKSPAAIREGVIKTEEPERLLEDCRLGAEPASNGLVHGSAEVILAPTSGAFGPHQQDLRIPLTLHTVPPGARIQFQGAPPSELIRLTKVPLTPVPTKMQSLLEPSVKIETKDVPLTVLPSDAGIPDTPFSKDRNGHVKRPMNAFMVWARIHRPALAKANPAANNAEISVQLGLEWNKLSEEQKKPYYDEAQKIKEKHREEFPGWVYQPRPGKRKRFPLSVSNVFSGTTQNIISTNPTTVYPYRSPTYSVVIPSLQNPITHPVGETSPAIQLPTPAVQSPSPVTLFQPSVSSAAQVAVQDPSLPVYPALPPQRFTGPSQTDTHQLHSEATHTVKQPTPVSLESANRISSSASTAHARFATSTIQPPREYSSVSPCPRSAPIPQASPIPHPHVYQPPPLGHPATLFGTPPRFSFHHPYFLPGPHYFPSSTCPYSRPPFGYGNFPSSMPECLSYYEDRYPKHEGIFSTLNRDYSFRDYSSECTHSENSRSCENMNGTSYYNSHSHSGEENLNPVPQLDIGTLENVFTAPTSTPSSIQQVNVTDSDEEEEEKVLRDL
uniprot
proteins
function
FUNCTION: Acts both as a transcriptional activator and a repressor (PubMed:10359848, PubMed:29739711). Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (PubMed:10359848). Binds to its own promoter and activates its own transcription (By similarity). Required to activate the expression of postmeiotic genes involved in spermiogenesis (By similarity). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (PubMed:29739711). {ECO:0000250|UniProtKB:Q8CGW4, ECO:0000269|PubMed:10359848, ECO:0000269|PubMed:29739711}.
uniprot
proteins
mass_dalton
81854
uniprot
proteins
pubmed
10359848
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
29739711
uniprot
proteins
sequence_length
753
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10359848, ECO:0000269|PubMed:29739711}. Cytoplasm {ECO:0000269|PubMed:29739711}. Note=Enriched at the chromocenter. {ECO:0000250|UniProtKB:Q8CGW4}.
uniprot
proteins