SNED1
entrez
25992
canonical
uniprot
Q8TER0
canonical
ensembl
ENSG00000162804
resolver
ensp
ENSP00000308893
resolver
ensp
ENSP00000384871
resolver
ensp
ENSP00000528351
resolver
ensp
ENSP00000599552
resolver
ensp
ENSP00000627468
resolver
genesymbol
SNED1
resolver
hgnc
HGNC:24696
resolver
uniprot
B5MDC3
resolver
uniprot
B7WNK6
resolver
uniprot
B7WPM0
resolver
uniprot
Q336F4
resolver
uniprot
Q336F5
resolver
uniprot
Q8N369
resolver
uniprot
Q8TEP7
resolver
uniprot_entry
SNED1_HUMAN
resolver
uniprot_sec
B5MDC3
resolver
uniprot_sec
B7WNK6
resolver
uniprot_sec
B7WPM0
resolver
uniprot_sec
Q336F4
resolver
uniprot_sec
Q336F5
resolver
uniprot_sec
Q8N369
resolver
uniprot_sec
Q8TEP7
resolver
amino_acid_sequence
MRHGVAWALLVAAALGLGARGVRGAVALADFYPFGAERGDAVTPKQDDGGSGLRPLSVPFPFFGAEHSGLYVNNNGIISFLKEVSQFTPVAFPIAKDRCVVAAFWADVDNRRAGDVYYREATDPAMLRRATEDVRHYFPELLDFNATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGKLSFTIFNYESIVWTTGTHASSGGNATGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVETTTNVGVPGRWAFRIDDAQVRVGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDCECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKELFPPTALKMERVEESGVSISWNPPNGPAARQMLDGYAVTYVSSDGSYRRTDFVDRTRSSHQLQALAAGRAYNISVFSVKRNSNNKNDISRPAVLLARTRPRPVEGFEVTNVTASTISVQWALHRIRHATVSGVRVSIRHPEALRDQATDVDRSVDRFTFRALLPGKRYTIQLTTLSGLRGEEHPTESLATAPTHVWTRPLPPANLTAARVTATSAHVVWDAPTPGSLLEAYVINVTTSQSTKSRYVPNGKLASYTVRDLLPGRRYQLSVIAVQSTELGPQHSEPAHLYIITSPRDGADRRWHQGGHHPRVLKNRPPPARLPELRLLNDHSAPETPTQPPRFSELVDGRGRVSARFGGSPSKAATVRSQPTASAQLENMEEAPKRVSLALQLPEHGSKDIGNVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGGVCHHVYKRVYRVHQDICFKESCESTSLKKTPNRKQSKSQTLEKS
uniprot
proteins
function
FUNCTION: Mediates cell adhesion via integrins ITGA5:ITGB1 and ITGAV:ITGB3 which bind to the R-G-D cell attachment site in SNED1 (PubMed:39713860). Cell adhesion is also likely to occur through additional integrin and/or non-integrin receptors at the cell surface (PubMed:39713860). Plays a role in craniofacial morphogenesis (By similarity). {ECO:0000250|UniProtKB:Q70E20, ECO:0000269|PubMed:39713860}.
uniprot
proteins
mass_dalton
152204
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="D->E: Decreases cell adhesion."; /evidence="ECO:0000269|PubMed:39713860"; MUTAGEN 311; /note="D->A: No effect on cell adhesion."; /evidence="ECO:0000269|PubMed:39713860
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues. {ECO:0000269|PubMed:33724335}.; PTM: N-glycosylated. {ECO:0000269|PubMed:33724335}.
uniprot
proteins
pubmed
15194686
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
33724335
uniprot
proteins
pubmed
39713860
uniprot
proteins
sequence_length
1413
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:33724335}. Note=Forms microfibrils within the extracellular matrix and colocalizes with fibronectin (FN1). {ECO:0000250|UniProtKB:Q70E20}.
uniprot
proteins