TRAF1
entrez
7185
canonical
uniprot
Q13077
canonical
ensembl
ENSG00000056558
resolver
ensp
ENSP00000362994
resolver
ensp
ENSP00000438583
resolver
ensp
ENSP00000443183
resolver
genesymbol
TRAF1
resolver
genesymbol_syn
EBI6
resolver
hgnc
HGNC:12031
resolver
uniprot
B4DJ77
resolver
uniprot
Q658U1
resolver
uniprot
Q8NF13
resolver
uniprot_entry
TRAF1_HUMAN
resolver
uniprot_sec
B4DJ77
resolver
uniprot_sec
Q658U1
resolver
uniprot_sec
Q8NF13
resolver
amino_acid_sequence
MASSSGSSPRPAPDENEFPFGCPPTVCQDPKEPRALCCAGCLSENPRNGEDQICPKCRGEDLQSISPGSRLRTQEKAHPEVAEAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMALEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVETST
uniprot
proteins
function
FUNCTION: Adapter molecule that is involved in multiple signaling pathways including the NF-kappa-B and MAPK pathways and thus influences inflammatory and apoptotic responses. Plays a critical role in regulating T-cell activation both through restricting the costimulation-independent activation of NIK in activated T-cells and by promoting the TNFRSF9-induced classical NF-kappa-B pathway (By similarity). Forms a heterotrimer with TRAF2 as part of an E3 ubiquitin-protein ligase complex that mediates ubiquitination of target proteins such as MAP3K14 and gasdermin D/GSDMD (PubMed:40097387). This complex also recruits the antiapoptotic E3 ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (PubMed:19287455). Acts downstream of MAVS within the RIG-I/MAVS antiviral pathway to enhance type I interferon signaling (PubMed:38995016). Regulates osteoclastogenesis by preventing ubiquitination and degradation of MLST8, thereby promoting PI3K-AKT signaling and enhancing oxidative phosphorylation in osteoclasts (By similarity). {ECO:0000250|UniProtKB:P39428, ECO:0000269|PubMed:10692572, ECO:0000269|PubMed:16323247, ECO:0000269|PubMed:18429822, ECO:0000269|PubMed:19287455, ECO:0000269|PubMed:19698991, ECO:0000269|PubMed:20385093, ECO:0000269|PubMed:38995016}.; FUNCTION: (Microbial infection) Amplifies LMP1-mediated MAP kinase and canonical NF-kappa-B pathway but not non-canonical NF-kappa-B pathway activity. {ECO:0000269|PubMed:25996949}.
uniprot
proteins
mass_dalton
46164
uniprot
proteins
mutagenesis
MUTAGEN 163; /note="D->A: Abolishes CASP8-mediated cleavage."; /evidence="ECO:0000269|PubMed:10692572, ECO:0000269|PubMed:16323247"; MUTAGEN 185; /note="K->R: Nearly abolished ubiquitination; when associated with R-193."; /evidence="ECO:0000269|PubMed:15468071"; MUTAGEN 193; /note="K->R: Nearly abolished ubiquitination; when associated with R-185."; /evidence="ECO:0000269|PubMed:15468071"; MUTAGEN 308; /note="R->D: Diminished interaction with TANK."; /evidence="ECO:0000269|PubMed:15468071"; MUTAGEN 325; /note="F->D: Diminished interaction with TANK."; /evidence="ECO:0000269|PubMed:15468071"; MUTAGEN 368; /note="S->D: Diminished interaction with TANK."; /evidence="ECO:0000269|PubMed:15468071
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation (PubMed:15468071, PubMed:19937093). Ubiquitinated by the SCF(FBXL2) complex, leading to its degradation by the proteasome (By similarity). {ECO:0000250|UniProtKB:P39428, ECO:0000269|PubMed:15468071, ECO:0000269|PubMed:19937093}.
uniprot
proteins
pubmed
10037686
uniprot
proteins
pubmed
10692572
uniprot
proteins
pubmed
10809768
uniprot
proteins
pubmed
10903733
uniprot
proteins
pubmed
11035039
uniprot
proteins
pubmed
11313261
uniprot
proteins
pubmed
11907583
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15383523
uniprot
proteins
pubmed
15468071
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16323247
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18429822
uniprot
proteins
pubmed
18987736
uniprot
proteins
pubmed
19287455
uniprot
proteins
pubmed
19698991
uniprot
proteins
pubmed
19937093
uniprot
proteins
pubmed
20385093
uniprot
proteins
pubmed
20447407
uniprot
proteins
pubmed
25996949
uniprot
proteins
pubmed
27151821
uniprot
proteins
pubmed
38995016
uniprot
proteins
pubmed
40097387
uniprot
proteins
pubmed
7859281
uniprot
proteins
pubmed
8069916
uniprot
proteins
pubmed
8627180
uniprot
proteins
pubmed
8710854
uniprot
proteins
pubmed
9418902
uniprot
proteins
pubmed
9607925
uniprot
proteins
pubmed
9642260
uniprot
proteins
pubmed
9705938
uniprot
proteins
pubmed
9718306
uniprot
proteins
pubmed
9774460
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:38995016}.
uniprot
proteins