P13236
uniprot
P13236
canonical
amino_acid_sequence
MKLCVTVLSLLMLVAAFCSPALSAPMGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRSKQVCADPSESWVQEYVYDLELN
uniprot
proteins
function
FUNCTION: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. {ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:12070155, ECO:0000269|PubMed:8525373}.
uniprot
proteins
mass_dalton
10212
uniprot
proteins
post_translational_modification
PTM: N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
10540332
uniprot
proteins
pubmed
12070155
uniprot
proteins
pubmed
12401480
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15843566
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
1894635
uniprot
proteins
pubmed
2247088
uniprot
proteins
pubmed
2462251
uniprot
proteins
pubmed
2521353
uniprot
proteins
pubmed
2521882
uniprot
proteins
pubmed
2568930
uniprot
proteins
pubmed
2809212
uniprot
proteins
pubmed
8134838
uniprot
proteins
pubmed
8525373
uniprot
proteins
pubmed
9521068
uniprot
proteins
sequence_length
92
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins