Hopx
entrez
74318
canonical
uniprot
Q8R1H0
canonical
ensembl
ENSMUSG00000059325
resolver
ensp
ENSMUSP00000080630
resolver
ensp
ENSMUSP00000109080
resolver
ensp
ENSMUSP00000113295
resolver
ensp
ENSMUSP00000180982
resolver
enst
ENSMUST00000081964
resolver
enst
ENSMUST00000113453
resolver
enst
ENSMUST00000120827
resolver
genesymbol
Hopx
resolver
genesymbol_syn
Hod
resolver
genesymbol_syn
Hop
resolver
genesymbol_syn
Ob1
resolver
uniprot
Q8C1N5
resolver
uniprot
Q8CJ22
resolver
uniprot_entry
HOP_MOUSE
resolver
uniprot_sec
Q8C1N5
resolver
uniprot_sec
Q8CJ22
resolver
amino_acid_sequence
MSAQTASGPTEDQVEILEYNFNKVNKHPDPTTLCLIAAEAGLTEEQTQKWFKQRLAEWRRSEGLPSECRSVTD
uniprot
proteins
function
FUNCTION: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (PubMed:12297045, PubMed:12297046). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (By similarity). {ECO:0000250|UniProtKB:Q9BPY8, ECO:0000269|PubMed:12297045, ECO:0000269|PubMed:12297046}.
uniprot
proteins
mass_dalton
8282
uniprot
proteins
mutagenesis
MUTAGEN 35..39; /note="LIAAE->AAASM: In H2; induces a strong reduction in interaction with SRF and subsequent ability to prevent transcription of cardiac-specific genes."; /evidence="ECO:0000269|PubMed:12297045"; MUTAGEN 49..53; /note="KWFKQ->AAASM: In H3; does not affect the interaction with SRF and keeps its ability to prevent transcription of cardiac-specific genes."; /evidence="ECO:0000269|PubMed:12297045
uniprot
proteins
pubmed
12297045
uniprot
proteins
pubmed
12297046
uniprot
proteins
pubmed
12975471
uniprot
proteins
pubmed
14516659
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
73
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12297045}. Cytoplasm {ECO:0000269|PubMed:14516659}. Note=According to PubMed:14516659 it is cytoplasmic. {ECO:0000269|PubMed:14516659}.
uniprot
proteins