PRR7
entrez
80758
canonical
uniprot
Q8TB68
canonical
ensembl
ENSG00000131188
resolver
ensp
ENSP00000327168
resolver
ensp
ENSP00000420872
resolver
ensp
ENSP00000421039
resolver
ensp
ENSP00000531694
resolver
genesymbol
PRR7
resolver
hgnc
HGNC:28130
resolver
uniprot
Q8WU53
resolver
uniprot
Q9BTA7
resolver
uniprot_entry
PRR7_HUMAN
resolver
uniprot_sec
Q8WU53
resolver
uniprot_sec
Q9BTA7
resolver
amino_acid_sequence
MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGSLAGSPPGLAPPQPPPHRSRLEAPAHAHSHPHVHVHPLLHHGPAQPHAHAHPHPHHHALPHPPPTHLSVPPRPWSYPRQAESDMSKPPCYEEAVLMAEPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPAPPCPALCLQADRGRRVFPSWTDSELSSREPLEHGAWRLPVSIPLFGRTTAV
uniprot
proteins
function
FUNCTION: Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222). Might promote apoptosis in T cells (PubMed:21460222). {ECO:0000250|UniProtKB:P0C6T3, ECO:0000250|UniProtKB:Q3V0I2, ECO:0000269|PubMed:21460222, ECO:0000269|PubMed:27458189}.
uniprot
proteins
mass_dalton
30930
uniprot
proteins
mutagenesis
MUTAGEN 139; /note="Y->F: Reduced induction of apoptosis; when associated with F-153; F-166; F-177; F-201 and F-210."; /evidence="ECO:0000269|PubMed:21460222"; MUTAGEN 153; /note="Y->F: Reduced induction of apoptosis; when associated with F-139; F-166; F-177; F-201 and F-210."; /evidence="ECO:0000269|PubMed:21460222"; MUTAGEN 166; /note="Y->F: Reduced induction of apoptosis; when associated with F-139; F-153; F-177; F-201 and F-210."; /evidence="ECO:0000269|PubMed:21460222"; MUTAGEN 177; /note="Y->F: Reduced induction of apoptosis; when associated with F-139; F-153; F-166; F-201 and F-210."; /evidence="ECO:0000269|PubMed:21460222"; MUTAGEN 201; /note="Y->F: Reduced induction of apoptosis; when associated with F-139; F-153; F-166; F-177 and F-210."; /evidence="ECO:0000269|PubMed:21460222"; MUTAGEN 210; /note="Y->F: Reduced induction of apoptosis; when associated with F-139; F-153; F-166; F-177 and F-201."; /evidence="ECO:0000269|PubMed:21460222
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. {ECO:0000269|PubMed:21460222}.; PTM: Tyrosine phosphorylated, possibly by SRC. {ECO:0000269|PubMed:21460222}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21460222
uniprot
proteins
pubmed
27458189
uniprot
proteins
sequence_length
274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21460222}; Single-pass type III membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P0C6T3}; Single-pass type III membrane protein {ECO:0000305}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P0C6T3}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21460222}. Synapse {ECO:0000269|PubMed:27458189}. Cell projection, dendrite {ECO:0000269|PubMed:27458189}. Nucleus {ECO:0000269|PubMed:27458189}. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern. Translocates from synapses to nuclei following NMDA receptor activity (By similarity). {ECO:0000250|UniProtKB:P0C6T3}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins