Plpp2
entrez
246115
canonical
uniprot
Q8K593
canonical
ensembl
ENSRNOG00000000177
resolver
ensembl
ENSRNOG00065020855
resolver
ensp
ENSRNOP00000000193
resolver
ensp
ENSRNOP00065028526
resolver
enst
ENSRNOT00000000193
resolver
enst
ENSRNOT00065035418
resolver
genesymbol
Plpp2
resolver
genesymbol_syn
Lpp2
resolver
genesymbol_syn
Ppap2c
resolver
uniprot_entry
PLPP2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Magnesium-independent phospholipid phosphatase. Insensitive to N-ethylmaleimide. {ECO:0000250|UniProtKB:O43688}.
uniprot
proteins
amino_acid_sequence
MERRWVFVLLDVLCVLVASLPFIILTLVNAPYKRGFYCGDDSIRYPYRPDTITHGLMAGVIITATVVLVSSGEAYLVYTDRLYSRSDFNNYVAAIYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSRVNCSGYVQVEVCRGSPANVTEARLSFYSGHSSFGMYCMLFLALYVQARLCWKWARLLRPTVQFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVACLTVCYVSDFFKSRPPQSCQENEESERKPSLSLTLTLGDRP
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
ec_number
3.1.3.4
uniprot
proteins
function
FUNCTION: Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (By similarity). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (PubMed:16467304). {ECO:0000250|UniProtKB:O43688, ECO:0000269|PubMed:16467304}.
uniprot
proteins
mass_dalton
31101
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000250|UniProtKB:O43688}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:O43688}.
uniprot
proteins
protein_family
PA-phosphatase related phosphoesterase family
uniprot
proteins
pubmed
11704545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16467304
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:O43688}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:O43688}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:O43688}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43688}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 162..182; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 226..246; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins