TRIP6
entrez
7205
canonical
uniprot
Q15654
canonical
ensembl
ENSG00000087077
resolver
ensp
ENSP00000200457
resolver
genesymbol
TRIP6
resolver
genesymbol_syn
OIP1
resolver
hgnc
HGNC:12311
resolver
uniprot
A4D2E7
resolver
uniprot
F2ZC07
resolver
uniprot
F2ZC08
resolver
uniprot
O15170
resolver
uniprot
O15275
resolver
uniprot
Q9BTB2
resolver
uniprot
Q9BUE5
resolver
uniprot
Q9BXP3
resolver
uniprot
Q9UNT4
resolver
uniprot_entry
TRIP6_HUMAN
resolver
uniprot_sec
A4D2E7
resolver
uniprot_sec
F2ZC07
resolver
uniprot_sec
F2ZC08
resolver
uniprot_sec
O15170
resolver
uniprot_sec
O15275
resolver
uniprot_sec
Q9BTB2
resolver
uniprot_sec
Q9BUE5
resolver
uniprot_sec
Q9BXP3
resolver
uniprot_sec
Q9UNT4
resolver
amino_acid_sequence
MSGPTWLPPKQPEPARAPQGRAIPRGTPGPPPAHGAALQPHPRVNFCPLPSEQCYQAPGGPEDRGPAWVGSHGVLQHTQGLPADRGGLRPGSLDAEIDLLSSTLAELNGGRGHASRRPDRQAYEPPPPPAYRTGSLKPNPASPLPASPYGGPTPASYTTASTPAGPAFPVQVKVAQPVRGCGPPRRGASQASGPLPGPHFPLPGRGEVWGPGYRSQREPGPGAKEEAAGVSGPAGRGRGGEHGPQVPLSQPPEDELDRLTKKLVHDMNHPPSGEYFGQCGGCGEDVVGDGAGVVALDRVFHVGCFVCSTCRAQLRGQHFYAVERRAYCEGCYVATLEKCATCSQPILDRILRAMGKAYHPGCFTCVVCHRGLDGIPFTVDATSQIHCIEDFHRKFAPRCSVCGGAIMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHILCKACSAWRIQELSATVTTDC
uniprot
proteins
function
FUNCTION: Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}.
uniprot
proteins
mass_dalton
50288
uniprot
proteins
mutagenesis
MUTAGEN 101; /note="S->A: Exclusively located in nucleus."; /evidence="ECO:0000269|PubMed:16624523"; MUTAGEN 102; /note="S->A: Exclusively located in nucleus."; /evidence="ECO:0000269|PubMed:16624523"; MUTAGEN 474; /note="T->A: Reduces interaction with MAGI1."; /evidence="ECO:0000269|PubMed:19017743
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13. {ECO:0000269|PubMed:15988003, ECO:0000269|PubMed:17591779}.
uniprot
proteins
protein_family
Zyxin/ajuba family
uniprot
proteins
pubmed
10400701
uniprot
proteins
pubmed
10826496
uniprot
proteins
pubmed
11239002
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14688263
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489293
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15988003
uniprot
proteins
pubmed
16137684
uniprot
proteins
pubmed
16624523
uniprot
proteins
pubmed
16880273
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17095609
uniprot
proteins
pubmed
17591779
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19017743
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7776974
uniprot
proteins
pubmed
9598321
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16624523}. Cell junction, focal adhesion {ECO:0000269|PubMed:16624523}. Nucleus {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:16624523}. Cytoplasm {ECO:0000269|PubMed:16624523}. Note=Shuttles between nucleus and cytoplasm (PubMed:16624523). Colocalizes with actin (PubMed:10826496). {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:16624523}.
uniprot
proteins