RTCA
entrez
8634
canonical
uniprot
O00442
canonical
ensembl
ENSG00000137996
resolver
ensp
ENSP00000260563
resolver
ensp
ENSP00000359146
resolver
genesymbol
RTCA
resolver
genesymbol_syn
RPC
resolver
genesymbol_syn
RPC1
resolver
genesymbol_syn
RTC1
resolver
genesymbol_syn
RTCD1
resolver
hgnc
HGNC:17981
resolver
uniprot
Q5VVL5
resolver
uniprot
Q5VVL6
resolver
uniprot
Q96E99
resolver
uniprot_entry
RTCA_HUMAN
resolver
uniprot_sec
Q5VVL5
resolver
uniprot_sec
Q5VVL6
resolver
uniprot_sec
Q96E99
resolver
amino_acid_sequence
MAGPRVEVDGSIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIRDLCDGQLEGAEIGSTEITFTPEKIKGGIHTADTKTAGSVCLLMQVSMPCVLFAASPSELHLKGGTNAEMAPQIDYTVMVFKPIVEKFGFIFNCDIKTRGYYPKGGGEVIVRMSPVKQLNPINLTERGCVTKIYGRAFVAGVLPFKVAKDMAAAAVRCIRKEIRDLYVNIQPVQEPKDQAFGNGNGIIIIAETSTGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLIVFMALANGVSRIKTGPVTLHTQTAIHFAEQIAKAKFIVKKSEDEEDAAKDTYIIECQGIGMTNPNL
uniprot
proteins
ec_number
6.5.1.4
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA (PubMed:9184239). The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product (PubMed:9184239). Likely functions in some aspects of cellular RNA processing (PubMed:25961792, PubMed:9184239). Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury (PubMed:25961792). {ECO:0000269|PubMed:25961792, ECO:0000269|PubMed:9184239}.
uniprot
proteins
mass_dalton
39337
uniprot
proteins
protein_family
RNA 3'-terminal cyclase family
uniprot
proteins
protein_family
Type 1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2199762
uniprot
proteins
pubmed
25961792
uniprot
proteins
pubmed
9184239
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:9184239}.
uniprot
proteins