E4f1
entrez
13560
canonical
uniprot
Q8CCE9
canonical
ensembl
ENSMUSG00000024137
resolver
ensp
ENSMUSP00000062344
resolver
ensp
ENSMUSP00000172955
resolver
ensp
ENSMUSP00000342560
resolver
genesymbol
E4f1
resolver
uniprot
Q05BH7
resolver
uniprot
Q3UNJ9
resolver
uniprot
Q62065
resolver
uniprot
Q6IR08
resolver
uniprot
Q6PGI1
resolver
uniprot
Q9QY56
resolver
uniprot_entry
E4F1_MOUSE
resolver
uniprot_sec
Q05BH7
resolver
uniprot_sec
Q3UNJ9
resolver
uniprot_sec
Q62065
resolver
uniprot_sec
Q6IR08
resolver
uniprot_sec
Q6PGI1
resolver
uniprot_sec
Q9QY56
resolver
amino_acid_sequence
MEGAMAVRVTAAHTAEARAEAGREAGEGGVAAAAALSSGGFLGLPAPFSEEDEDDVHRCGRCQVEFTALEDFVQHKIQKTCHRAPQEALPTTPAATALLDQEVVPTAAEGGPDEPITVAHIVVEATSLAEDISHAPDLVGSGHIKEVIVAAEAEPGDVEMAEAPGSPNHQELGLLGEGEQAHVKLLVNKEGRYVCMLCHKTFKTGSILKAHMVTHSSRKDHECKLCGASFRTKGSLIRHHRRHTDERPYKCAKCGKSFRESGALTRHLKSLTPCTEKIRFSISKDTAVGKEEVPAGSSASTVGTVTSSVAGDPMETSPVIHLVTDAKGTVIHEVHVQMQELPLGMKALTPESPDSEELPCSSENSRENLLHQAMQNSGIVLERVAGEESALEPAPPSGSSPQCLGDGSPELPLLKVEQIETQVASEAATVPRTHPCPQCSETFPTAATLEAHKRGHIAPRPFTCTQCGKAFPKAYLLKKHQEVHVHERRFRCGDCGKLYKTIAHVRGHRRVHSDERPFPCPQCGKRYKTKNAQQVHFRTHLEEKPHVCQFCSRGFREKGSLVRHVRHHTGEKPFKCYKCGRGFAEHGTLNRHLRTKGGCLLEVEELLVSEESPSAAATVLAEDPHTVLVEFSSVVADTQEYIIEATADDTETSEATEIIEGTQTEVDSHIMKVVQQIVHQAGAGHQIIVQNVTMDQETALGSEATAADTITIATPESLTEQVAMTLASAISEGTVLTARAGPNSTEQATVTMVSSEDIEILEHGGELVIASPEGQLEVQTVIV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription. {ECO:0000269|PubMed:10644996, ECO:0000269|PubMed:15226446, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:8262041}.
uniprot
proteins
mass_dalton
84296
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; phosphorylation is cell cycle-dependent and regulates DNA-binding activity and function. {ECO:0000269|PubMed:8262041}.; PTM: May be sumoylated by UBE2I upon interaction with CDKN2A. {ECO:0000250|UniProtKB:Q66K89}.
uniprot
proteins
pubmed
10644996
uniprot
proteins
pubmed
10869426
uniprot
proteins
pubmed
15226446
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17557114
uniprot
proteins
pubmed
8262041
uniprot
proteins
pubmed
9530632
uniprot
proteins
sequence_length
783
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:15226446, ECO:0000269|PubMed:8262041}. Cytoplasm {ECO:0000250}. Note=A small fraction is detected in the cytoplasm (By similarity). Excluded from the nucleolus where it is targeted upon CDKN2A overexpression. Localizes to the mitotic spindle during embryogenesis. {ECO:0000250}.
uniprot
proteins