LEUTX
entrez
342900
canonical
uniprot
A8MZ59
canonical
ensembl
ENSG00000213921
resolver
ensembl
ENSG00000280774
resolver
ensp
ENSP00000380053
resolver
ensp
ENSP00000491740
resolver
genesymbol
LEUTX
resolver
hgnc
HGNC:31953
resolver
uniprot
A0A1W2PQ33
resolver
uniprot_entry
LEUTX_HUMAN
resolver
uniprot_sec
A0A1W2PQ33
resolver
amino_acid_sequence
MFEGPRRYRRPRTRFLSKQLTALRELLEKTMHPSLATMGKLASKLQLDLSVVKIWFKNQRAKWKRQQRQQMQTRPSLGPANQTTSVKKEETPSAITTANIRPVSPGISDANDHDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV
uniprot
proteins
function
FUNCTION: [Isoform 1]: Paired-like homeobox transcription factor involved in embryogenesis (PubMed:27578796, PubMed:30479355). May act as a regulator of embryo genome activation (PubMed:27578796). Binds to a 36 bp DNA elements containing a 5'-TAATCC-3' sequence motif, referred to as EEA motif (EGA-enriched Alu-motif), present in the promoters of target genes activated in early embryos (PubMed:27578796, PubMed:30479355). {ECO:0000269|PubMed:27578796, ECO:0000269|PubMed:30479355}.; FUNCTION: [Isoform 2]: Inactive transcriptional activity. {ECO:0000269|PubMed:27578796}.
uniprot
proteins
mass_dalton
22358
uniprot
proteins
mutagenesis
MUTAGEN 54; /note="I->T: Increased transcriptional activity; when associated with Ala-61-Val, restores wild-type transcriptional activity."; /evidence="ECO:0000269|PubMed:30479355"; MUTAGEN 61; /note="A->V: Abolished catalytic activity; when associated with Ile-54-Thr, restores wild-type transcriptional activity."; /evidence="ECO:0000269|PubMed:30479355
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
17963489
uniprot
proteins
pubmed
27578796
uniprot
proteins
pubmed
30479355
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27578796}.
uniprot
proteins