Ptprq
entrez
360417
canonical
uniprot
O88488
canonical
ensembl
ENSRNOG00000056915
resolver
ensp
ENSRNOP00000069293
resolver
enst
ENSRNOT00000081885
resolver
genesymbol
Ptprq
resolver
genesymbol_syn
Ptpgmc1
resolver
uniprot
A0A0G2JUZ7
resolver
uniprot_entry
A0A0G2JUZ7_RAT
resolver
uniprot_entry
PTPRQ_RAT
resolver
amino_acid_sequence
MMDFHFSFLFLLIGTSESQVDVSSSFDGTGYDITLSSVSATTYSSPVSRTLATNVTKPGPPVFLAGERVGSAGILLSWNTPPNPNGRIISYVVKYKEVCPWMQTAYTRARAKPDSLEVLLTNLNPGTTYEIKVAAENNAGIGVFSDPFLFQTAESAPGKVVNLTVEALNYSAVNLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSLRVEDILSGKLPECNENSESFLWSTTSPSPTLGRVTPTVRTTQSSSTAARSKISSVWKEPISFVVTHLRPYTTYLFEVSAVTTEAGYIDSTIVRTPESVPEGPPQNCIMGNVTGKAFSISWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLRFAFTHLTPFTMYDVYVAAETSAGVGPKSNLSVFTPPDVPGAVFDLQIAEVEATEIRITWRKPRQPNGIISQYRVKVSVLETGVVLENTLLTGQDESISNPMSPEIMNLVDPMIGFYEGSGEMSSDLHSPASFIYNSHPHNDFPASTRAEEQSSPVVTTRNQYMTDITAEQLSYVVRRLVPFTEHTISVSAFTIMGEGPPTVLTVRTREQVPSSIQIINYKNISSSSILLYWDPPEYPNGKITHYTIYATELDTNRAFQMTTVDNSFLITGLKKYTRYKMRVAASTHVGESSLSEENDIFVRTPEDEPESSPQDVQVTGVSPSELRLKWSPPEKPNGIIIAYEVLYQNADTLFVKNTSTTDIIISDLKPYTLYNISIRSYTRLGHGNQSSSLLSVRTSETVPDSAPENITYKNISSGEIEISFLPPRSPNGIIQKYTIYLKRSNSHEARTINTTSLTQTIGGLKKYTHYVIEVSASTLKGEGIRSRPISILTEEDAPDSPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDKSSLRAINATEASLVLSDLDYNVDYGACVTASTRFGDGNARSSIINFRTPEGEPSDPPNDVHYVNLSSSSIILFWTPPVKPNGIIQYYSVYYQNTSGTFVQNFTLLQVTKESDNVTVSARIYRLAIFSYYTFWLTASTSVGNGNKSSDIIHVYTDQDIPEGPVGNLTFESISSTAIHVSWEPPSQPNGLVFYYLSLNLQQSPPRHMIPPLVTYENSIDFDDLEKYTDYIFKITPSTEKGFSETYTTQLHIKTEEDVPDTPPIINTFKNLSSTSILLSWDPPLKPNGAILGYHLTLQGPHANHTFVTSGNHIVLEELSPFTLYSFFAAARTMKGLGPSSILFFYTDESAPLAPPQNLTLINYTSDFVWLTWSPSPLPGGIVKVYSFKIHEHETDTVFYKNISGLQTDAKLEGLEPVSTYSVSVSAFTKVGNGNQYSNVVEFTTQESVPEAVRNIECVARDWQSVSVRWDPPRKTNGIIIHYMITVGGNSTKVSPRDPTYTFTKLLPNTSYVFEVRASTSAGEGNESRCDISTLPETVPSAPTNVAFSNVQSTSATLTWTKPDTIFGYFQNYKITTQLRAQKCREWEPEECIEHQKDQYLYEANQTEETVHGLKKFRWYRFQVAASTNVGYSNASEWISTQTLPGPPDGPPENVHVVATSPFGINISWSEPAVITGPTFYLIDVKSVDDDDFNISFLKSNEENKTTEINNLEVFTRYSVVITAFVGNVSRAYTDGKSSAEVIITTLESVPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIRVYQALVYREDDPTAVQIHNFSIIQKTDTSIIAMLEGLKGGHTYNISVYAINSAGAGPKVQMRITMDIKAPARPKSKPIPIRDATGKLLVTSTTITIRMPICYYNDDHGPIRNVQVLVAETGAQQDGNVTKWYDAYFNKARPYFTNEGFPNPPCIEGKTKFSGNEEIYVIGADNACMIPGNEEKICNGPLKPKKQYLFKFRATNVMGQFTDSEYSDPIKTLGEGLSERTVEIILSVTLCILSIILLGTAIFAFVRIRQKQKEGGTYSPRDAEIIDTKFKLDQLITVADLELKDERLTRLLSYRKSIKPISKKSFLQHVEELCTNSNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADVSLPGSDYINASYVSGYLCPNEFIATQGPLPGTVGDFWRMVWETRTKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDIQIDWTIRDLKIERHGDCMTVRQCNFTGWPEHGVPENTTPLIHFVKLVRTSRAHDTTPMVVHCSAGVGRTGVFIALDHLTQHINNHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGGHQPVCFVNYSTLQKMDSLDAMEGDVELEWEETTM
uniprot
proteins
ec_number
3.1.3.36
uniprot
proteins
ec_number
3.1.3.67
uniprot
proteins
ec_number
3.1.3.86
uniprot
proteins
ec_number
3.1.3.95
uniprot
proteins
function
FUNCTION: Dephosphorylates phosphatidylinositol phosphates, such as phosphatidylinositol 3,4,5-trisphosphate (PIP3) and phosphatidylinositol 3,5-diphosphates, with preference for PIP3 (PubMed:12802008). Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring (PubMed:12802008). Has low tyrosine-protein phosphatase activity in vitro; however, the relevance of such activity in vivo is unclear (PubMed:12802008). Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by regulating the levels of PIP3 level in MSCs and preadipocyte cells (By similarity). Required for hair bundle maturation, a process that enables hair cells to detect and transmit sound and balance signals effectively, therefore affecting auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles (By similarity). {ECO:0000250|UniProtKB:P0C5E4, ECO:0000250|UniProtKB:Q9UMZ3, ECO:0000269|PubMed:12802008}.
uniprot
proteins
mass_dalton
256824
uniprot
proteins
mutagenesis
MUTAGEN 2171; /note="E->D: Enhances the tyrosine-protein phosphatase activity but abolishes the phosphatidylinositol phosphatase activity."; /evidence="ECO:0000269|PubMed:12802008"; MUTAGEN 2203; /note="C->S: Abolishes the weak tyrosine-protein phosphatase activity."; /evidence="ECO:0000269|PubMed:12802008
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 2A subfamily
uniprot
proteins
pubmed
12802008
uniprot
proteins
pubmed
12837292
uniprot
proteins
pubmed
9727007
uniprot
proteins
sequence_length
2302
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, stereocilium {ECO:0000250|UniProtKB:P0C5E4}. Apical cell membrane {ECO:0000250|UniProtKB:P0C5E4}; Single-pass type I membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000250|UniProtKB:Q9UMZ3}; Single-pass type I membrane protein {ECO:0000255}. Note=Detected at the stereocilium base and at the apical cell membrane in mature hair cells (By similarity). Forms ring-like structures in the stereocilium taper region (By similarity). Detected at the basal cell membrane in fetal kidney podocytes (By similarity). A small isoform that lacks the N-terminal part and starts after the transmembrane region localizes in the cytoplasm (PubMed:12837292). {ECO:0000250|UniProtKB:P0C5E4, ECO:0000250|UniProtKB:Q9UMZ3, ECO:0000269|PubMed:12837292}.
uniprot
proteins
transmembrane_region
TRANSMEM 1909..1929; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins