SLC31A2
entrez
1318
canonical
uniprot
O15432
canonical
ensembl
ENSG00000136867
resolver
ensp
ENSP00000259392
resolver
enst
ENST00000259392
resolver
genesymbol
SLC31A2
resolver
genesymbol_syn
COPT2
resolver
genesymbol_syn
CTR2
resolver
hgnc
HGNC:11017
resolver
uniprot
Q53X94
resolver
uniprot_entry
COPT2_HUMAN
resolver
uniprot_entry
Q53X94_HUMAN
resolver
amino_acid_sequence
MAMHFIFSDTAVLLFDFWSVHSPAGMALSVLVLLLLAVLYEGIKVGKAKLLNQVLVNLPTSISQQTIAETDGDSAGSDSFPVGRTHHRWYLCHFGQSLIHVIQVVIGYFIMLAVMSYNTWIFLGVVLGSAVGYYLAYPLLSTA
uniprot
proteins
function
FUNCTION: Does not function as a copper(1+) importer in vivo (By similarity). However, in vitro functions as a low-affinity copper(1+) importer (PubMed:17617060, PubMed:17944601). Regulator of SLC31A1 which facilitates the cleavage of the SLC31A1 ecto-domain or which stabilizes the truncated form of SLC31A1 (Truncated CTR1 form), thereby drives the SLC31A1 truncated form-dependent endosomal copper export and modulates the copper and cisplatin accumulation via SLC31A1 (By similarity). {ECO:0000250|UniProtKB:Q9CPU9, ECO:0000269|PubMed:17617060, ECO:0000269|PubMed:17944601}.
uniprot
proteins
mass_dalton
15681
uniprot
proteins
mutagenesis
MUTAGEN 1..3; /note="MAM->AAA: Slightly decreases Cu(2+) affinity at pH 7.4. Decreases about 3 times the Cu(2+) affinity at pH 7.4 compared to wild-type."; /evidence="ECO:0000269|PubMed:31083932"; MUTAGEN 4; /note="H->A: Decreases almost 7 times the Cu(2+) affinity at pH 7.4 compared to wild-type. Decreases almost 10 times the Cu(2+) affinity at pH 7.4 compared to wild-type."; /evidence="ECO:0000269|PubMed:31083932
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; ubiquitination and the subsequent proteasomal degradation are prevent by SLC31A1 that stabilizes it. {ECO:0000269|PubMed:26205368}.
uniprot
proteins
protein_family
Copper transporter (Ctr) (TC 1.A.56) family
uniprot
proteins
protein_family
SLC31A subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17617060
uniprot
proteins
pubmed
17944601
uniprot
proteins
pubmed
26205368
uniprot
proteins
pubmed
31083932
uniprot
proteins
pubmed
9207117
uniprot
proteins
sequence_length
143
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:17944601}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17944601}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:17617060}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17617060}; Multi-pass membrane protein {ECO:0000255}. Note=Plasma membrane localization is partial. {ECO:0000269|PubMed:17944601}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins