ITGA5
entrez
3678
canonical
uniprot
P08648
canonical
ensembl
ENSG00000161638
resolver
ensp
ENSP00000293379
resolver
enst
ENST00000293379
resolver
genesymbol
ITGA5
resolver
genesymbol_syn
FNRA
resolver
hgnc
HGNC:6141
resolver
uniprot
B2R627
resolver
uniprot
Q96HA5
resolver
uniprot_entry
B2R627_HUMAN
resolver
uniprot_entry
ITA5_HUMAN
resolver
uniprot_sec
Q96HA5
resolver
amino_acid_sequence
MGSRTPESPLHAVQLRWGPRRRPPLLPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFFGFSVEFYRPGTDGVSVLVGAPKANTSQPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRLLESSLSSSEGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLSTDNFTRILEYAPCRSDFSWAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQIAESYYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTYGYVTILNGSDIRSLYNFSGEQMASYFGYAVAATDVNGDGLDDLLVGAPLLMDRTPDGRPQEVGRVYVYLQHPAGIEPTPTLTLTGHDEFGRFGSSLTPLGDLDQDGYNDVAIGAPFGGETQQGVVFVFPGGPGGLGSKPSQVLQPLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKAVVYRGRPIVSASASLTIFPAMFNPEERSCSLEGNPVACINLSFCLNASGKHVADSIGFTVELQLDWQKQKGGVRRALFLASRQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPQAPVDSHGLRPALHYQSKSRIEDKAQILLDCGEDNICVPDLQLEVFGEQNHVYLGDKNALNLTFHAQNVGEGGAYEAELRVTAPPEAEYSGLVRHPGNFSSLSCDYFAVNQSRLLVCDLGNPMKAGASLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNSQSDVVSFRLSVEAQAQVTLNGVSKPEAVLFPVSDWHPRDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQALEGQQLLYVTRVTGLNCTTNHPINPKGLELDPEGSLHHQQKREAPSRSSASSGPQILKCPEAECFRLRCELGPLHQQESQSLQLHFRVWAKTFLQREHQPFSLQCEAVYKALKMPYRILPRQLPQKERQVATAVQWTKAEGSYGVPLWIIILAILFGLLLLGLLIYILYKLGFFKRSLPYGTAMEKAQLKPPATSDA
uniprot
proteins
function
FUNCTION: Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). ITGA5:ITGB1 acts as a receptor for SNED1 and mediates R-G-D-dependent cell adhesion to SNED1 (PubMed:39713860). {ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:33962943, ECO:0000269|PubMed:39713860}.; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. {ECO:0000269|PubMed:12907437}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. {ECO:0000269|PubMed:24478423}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.
uniprot
proteins
mass_dalton
114536
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage by PCSK5 mediates activation of the precursor. {ECO:0000269|PubMed:22740495}.
uniprot
proteins
protein_family
Integrin alpha chain family
uniprot
proteins
pubmed
10094488
uniprot
proteins
pubmed
10397733
uniprot
proteins
pubmed
11912194
uniprot
proteins
pubmed
12695522
uniprot
proteins
pubmed
12807887
uniprot
proteins
pubmed
12907437
uniprot
proteins
pubmed
14596610
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16051604
uniprot
proteins
pubmed
16569642
uniprot
proteins
pubmed
16754960
uniprot
proteins
pubmed
17158881
uniprot
proteins
pubmed
1834647
uniprot
proteins
pubmed
18635536
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22451694
uniprot
proteins
pubmed
22740495
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24011356
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24478423
uniprot
proteins
pubmed
2450560
uniprot
proteins
pubmed
25398877
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26076738
uniprot
proteins
pubmed
29030430
uniprot
proteins
pubmed
2944883
uniprot
proteins
pubmed
2958481
uniprot
proteins
pubmed
3033641
uniprot
proteins
pubmed
31331973
uniprot
proteins
pubmed
32908006
uniprot
proteins
pubmed
33102950
uniprot
proteins
pubmed
33962943
uniprot
proteins
pubmed
37184585
uniprot
proteins
pubmed
39713860
uniprot
proteins
pubmed
7504269
uniprot
proteins
sequence_length
1049
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17158881}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000269|PubMed:17158881}.
uniprot
proteins
transmembrane_region
TRANSMEM 996..1021; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins