Psma6
entrez
26443
canonical
uniprot
Q9QUM9
canonical
ensembl
ENSMUSG00000021024
resolver
ensp
ENSMUSP00000021412
resolver
ensp
ENSMUSP00000124781
resolver
enst
ENSMUST00000021412
resolver
enst
ENSMUST00000163070
resolver
genesymbol
Psma6
resolver
uniprot
E0CXB1
resolver
uniprot
Q0VGS3
resolver
uniprot
Q3TT07
resolver
uniprot
Q3U6Y2
resolver
uniprot_entry
E0CXB1_MOUSE
resolver
uniprot_entry
PSA6_MOUSE
resolver
uniprot_sec
Q0VGS3
resolver
uniprot_sec
Q3TT07
resolver
uniprot_sec
Q3U6Y2
resolver
amino_acid_sequence
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITESIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:16581775, ECO:0000269|PubMed:22341445}.
uniprot
proteins
mass_dalton
27372
uniprot
proteins
protein_family
Peptidase T1A family
uniprot
proteins
pubmed
10436176
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16317774
uniprot
proteins
pubmed
16581775
uniprot
proteins
pubmed
16857966
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22078707
uniprot
proteins
pubmed
22341445
uniprot
proteins
pubmed
22556278
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
246
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22078707}. Nucleus {ECO:0000269|PubMed:22078707}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (By similarity). Colocalizes with TRIM5 in cytoplasmic bodies (PubMed:22078707). {ECO:0000250|UniProtKB:P60900, ECO:0000269|PubMed:22078707}.
uniprot
proteins