P21807
uniprot
P21807
canonical
amino_acid_sequence
MSHHSSGLRSSISSTSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSGSPSSSARLGSFRAPRAGALRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLGALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYENIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLSLKTTVPEVEPPQDSHSRKMVLIRTIETRDGEKVVTESQKEQHSELDKSSIHSY
uniprot
proteins
function
FUNCTION: Class-III neuronal intermediate filament protein (PubMed:2624740, PubMed:3339087). My form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (By similarity). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity). Plays a role in the development of unmyelinated sensory neurons (By similarity). May be involved in axon elongation and axon regeneration after injury (PubMed:2585054, PubMed:7530776). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity). {ECO:0000250|UniProtKB:P15331, ECO:0000269|PubMed:2585054, ECO:0000269|PubMed:2624740, ECO:0000269|PubMed:3339087, ECO:0000269|PubMed:7530776}.
uniprot
proteins
mass_dalton
53550
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; phosphorylation increases after nerve injury in regenerating neurons. {ECO:0000269|PubMed:17569669}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
17268851
uniprot
proteins
pubmed
17569669
uniprot
proteins
pubmed
19913522
uniprot
proteins
pubmed
2126481
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2585054
uniprot
proteins
pubmed
2624740
uniprot
proteins
pubmed
3272173
uniprot
proteins
pubmed
3339087
uniprot
proteins
pubmed
3418352
uniprot
proteins
pubmed
7530776
uniprot
proteins
pubmed
8575457
uniprot
proteins
pubmed
9388258
uniprot
proteins
pubmed
9453548
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17569669}. Cell projection, axon {ECO:0000269|PubMed:17569669}. Perikaryon {ECO:0000269|PubMed:17569669, ECO:0000269|PubMed:2126481, ECO:0000269|PubMed:2585054}.
uniprot
proteins