Arhgap10
entrez
78514
canonical
uniprot
Q6Y5D8
canonical
ensembl
ENSMUSG00000037148
resolver
ensp
ENSMUSP00000075658
resolver
ensp
ENSMUSP00000147485
resolver
ensp
ENSMUSP00000147493
resolver
ensp
ENSMUSP00000166779
resolver
ensp
ENSMUSP00000166787
resolver
ensp
ENSMUSP00000166798
resolver
ensp
ENSMUSP00000166800
resolver
genesymbol
Arhgap10
resolver
uniprot
Q6Y5D6
resolver
uniprot
Q6Y5D7
resolver
uniprot
Q8C9L7
resolver
uniprot
Q99MT3
resolver
uniprot
Q99MT4
resolver
uniprot_entry
Q8C9L7_MOUSE
resolver
uniprot_entry
RHG10_MOUSE
resolver
uniprot_sec
Q6Y5D6
resolver
uniprot_sec
Q6Y5D7
resolver
uniprot_sec
Q99MT3
resolver
uniprot_sec
Q99MT4
resolver
amino_acid_sequence
MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLISATKSLSAAQRKFAHSLRDFKFEFIGDAETDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLTLSARKKDSHLQEADLQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELSKDFNHYKMELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDQKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKTAKKFNMIPFEHRSGGKLGDGEAFFLKECTKRHMDSTDRRFCFDIEAADRPGVPLTVQAFSEEERKQWLEALGGKEALFHTFNRAIVPRPEGGAQLDKMGFTILRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKMCNELDLENSADWEVKTVTSALKQYLRSLPEPLMTYELHRDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSSHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIENHEKIFRTSPDTTFAEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEEGDSPSPLKEDPPSSSQDSLSTPSPTTSAAHGPPGLDGNHLAADGGSCGDATATTPSQTRPSMVQWLNMQSPTTPSSNPAGTPPSPRMSPFPLSPAASIVDKLPECVINRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL
uniprot
proteins
function
FUNCTION: GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11238453). Also converts Cdc42 to an inactive GDP-bound state (By similarity). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases (PubMed:11238453). Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (PubMed:15471851). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (By similarity). {ECO:0000250|UniProtKB:A1A4S6, ECO:0000269|PubMed:11238453, ECO:0000269|PubMed:15471851}.
uniprot
proteins
mass_dalton
89366
uniprot
proteins
mutagenesis
MUTAGEN 418; /note="R->Q: Inactive. Abolishes GTPase activity in vitro. Greatly diminishes cytoskeletal reorganization."; /evidence="ECO:0000269|PubMed:11238453
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues, probably involving PTK2B/PYK2.
uniprot
proteins
pubmed
11238453
uniprot
proteins
pubmed
15471851
uniprot
proteins
sequence_length
786
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Endosome membrane {ECO:0000250|UniProtKB:A1A4S6}. Note=Association to cell membrane is dependent on PH domain. Colocalized with MICAL1, RAB8A, RAB8B and RAB10 on endosomal tubules (By similarity). {ECO:0000250|UniProtKB:A1A4S6}.
uniprot
proteins