Rrp8
entrez
308911
canonical
uniprot
Q5U4F0
canonical
ensembl
ENSRNOG00000018766
resolver
ensp
ENSRNOP00000025651
resolver
enst
ENSRNOT00000025651
resolver
genesymbol
Rrp8
resolver
uniprot
A0A8L2QDU0
resolver
uniprot_entry
A0A8L2QDU0_RAT
resolver
uniprot_entry
RRP8_RAT
resolver
amino_acid_sequence
MFEEPEWVEAAPAIVGLRPVTTQVQAATAPPVKGRKRRHLLATLRALEAASLSQQCPSLPGSDSEEEEEVGRKKRHFQRSSLANVSKEVGKKRKGKCQKQAPFISDSEGKEVERTCHRQAPPLGGISAGEEKGKRKCQEYSYLHPTQSLNSVDQTVHNSRTSTATLDPPKSSRESASPNSSHTLSRKQWRNRQKNKRRHKNKFRPLETQDQVPLKASIEETEVPPAPKSDSQETRAGALRARMTQRLDGARFRYLNEQLYSGPSSAAQCLFQEDPEAFLLYHRGFQRQVKKWPLHPVDRIAKDLRQKPASLVVADFGCGDCRLASSVRNPVHCFDLAALDPRVTVCDMAQVPLEDESVDVAVFCLSLMGTNIRDFLEEANRVLKPGGLLKVAEVSSRFEDIRTFLGAVTKLGFKVIYKDLTNSHFFLFDFEKTGPPRVGPKAQLSGLKLQPCLYKHR
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
51216
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
protein_family
RRP8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
457
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Note=Localizes at rDNA locus. {ECO:0000250}.
uniprot
proteins