Atl3
entrez
309187
canonical
uniprot
Q0ZHH6
canonical
ensembl
ENSRNOG00000021203
resolver
ensp
ENSRNOP00000092838
resolver
enst
ENSRNOT00000106102
resolver
genesymbol
Atl3
resolver
uniprot
A0A8I6AEN1
resolver
uniprot_entry
A0A8I6AEN1_RAT
resolver
uniprot_entry
ATLA3_RAT
resolver
amino_acid_sequence
MLSPQRTAAVASRGAGDAMENGKPGPVQVVLVHKEQHSFELEERALASVLLQDHIRDLDVVVVSVAGAFRKGKSFILDFMLRYLYSQKEHGHSNWLGDPEEPLTGFSWRGGSDPETTGIQIWSEVFTVKKPCGKEVAVVLMDTQGAFDSQSTVKDCATIFALSTMTSSVQIYNLSQNIQEDDLQQLQLFTEYGRLAMDEIFQKPFQTLMFLVRDWSFPYEYNYGLQGGMSFLDKRLQVKEHQHEEIQNVRNHIHSCFSDVTCFLLPHPGLQVATSPDFDGKLKEYIASEFKEQLQTLIPYVLNPSKLMEKEINGSKVTCRGLLEYFKAYIKIYQGEDLPHPKSMLQATAANNLAAAASAKDIYYSSMEEICGGEKPYLSPDILEEKHQEFKQLALDHFKKTKKMGGKDFSFRYQQELEEEITELYENFCKHNGSKNVFSTFRTPAVLFTGIAVLYIASGLTGFIGLEVVAQLFNCMVGLLLIALLTWGYIRYSGQYLELGGAIDSGAAYVLEQASSHIGNSTQAAVRDAIAGRPPADKKSQ
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Atlastin-3 (ATL3) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (By similarity). Two atlastin-3 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity). {ECO:0000250|UniProtKB:Q6DD88, ECO:0000250|UniProtKB:Q8WXF7}.
uniprot
proteins
mass_dalton
60586
uniprot
proteins
protein_family
GB1 subfamily
uniprot
proteins
protein_family
GB1/RHD3 GTPase family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
14506257
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6DD88}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6DD88}. Note=Localizes to endoplasmic reticulum tubules and accumulates in punctuate structures corresponding to 3-way junctions, which represent crossing-points at which the tubules build a polygonal network. {ECO:0000250|UniProtKB:Q6DD88}.
uniprot
proteins
transmembrane_region
TRANSMEM 446..466; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 468..488; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins