Asb11
entrez
68854
canonical
uniprot
Q9CQ31
canonical
ensembl
ENSMUSG00000031382
resolver
ensp
ENSMUSP00000033755
resolver
ensp
ENSMUSP00000044637
resolver
ensp
ENSMUSP00000175125
resolver
ensp
ENSMUSP00000175128
resolver
genesymbol
Asb11
resolver
uniprot
A2AIH7
resolver
uniprot
Q3UJ13
resolver
uniprot
Q9D0V1
resolver
uniprot_entry
ASB11_MOUSE
resolver
uniprot_sec
A2AIH7
resolver
uniprot_sec
Q3UJ13
resolver
uniprot_sec
Q9D0V1
resolver
amino_acid_sequence
MEDAPAFYGFKNIFLTMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGLSDCWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNAQTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEIYLASPIHEAVKRGHRECMEILLTKDVNIEQEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAVRQSSVEVINLLTVYGANLNLRNAQGKSALDLAVPKSSVRQALLLHEGPPALSQLCRLCVRKCLGRTCHHAIYALGLPESLEKFLLYQ
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as BIK, DIRAS2 and RPN1. The ECS(ASB11) complex acts as a regulator of the endoplasmic reticulum unfolded protein response by mediating ubiquitination and degradation of BIK. {ECO:0000250|UniProtKB:Q8WXH4}.
uniprot
proteins
mass_dalton
35331
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8WXH4}.
uniprot
proteins
protein_family
Ankyrin SOCS box (ASB) family
uniprot
proteins
pubmed
11509662
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8WXH4}.
uniprot
proteins