Tfb1m
entrez
224481
canonical
uniprot
Q8JZM0
canonical
ensembl
ENSMUSG00000036983
resolver
ensp
ENSMUSP00000035291
resolver
ensp
ENSMUSP00000354627
resolver
enst
ENSMUST00000041003
resolver
genesymbol
Tfb1m
resolver
uniprot_entry
TFB1M_MOUSE
resolver
amino_acid_sequence
MAASGKLGTFRLPPLPTIREIIKLFGLRAVKQLSQNFLLDLRLTDKIVRKAGSLADVYVYEVGPGPGGITRSILNANVAELLVVEKDTRFIPGLQMLSDAAPGKLRIVHGDVLTYKIEKAFPGNIRRQWEDDPPNVHIIGNLPFSVSTPLIIKWLENISLKDGPFVYGRTKMTLTFQKEVAERLVATTGSKQHSRLSIMAQYLCNVEHLFTIPGKAFVPKPKVDVGVVHLTPLIEPKIKQPFKLVEKVVQNAFQFRRKYCHRGLGMLFPEAQRLESTGRLLQLADIDPTLRPTHLSLMHFKSLCDVYRKMCDEDPQLFTYNFREELKQKKSKGQEKDGDPESCGF
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Mitochondrial methyltransferase which uses S-adenosyl methionine to dimethylate two highly conserved adjacent adenosine residues (A1006 and A1007) within the loop of helix 45 at the 3-prime end of 12S rRNA, thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome (PubMed:19356719). Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity). {ECO:0000250|UniProtKB:Q8WVM0, ECO:0000269|PubMed:19356719}.
uniprot
proteins
mass_dalton
38962
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
KsgA subfamily
uniprot
proteins
protein_family
rRNA adenine N(6)-methyltransferase family
uniprot
proteins
pubmed
12068295
uniprot
proteins
pubmed
12532263
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19356719
uniprot
proteins
pubmed
23804760
uniprot
proteins
pubmed
35676484
uniprot
proteins
sequence_length
345
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8WVM0}.
uniprot
proteins