TBC1D3I
entrez
102724862
canonical
uniprot
A0A087WXS9
canonical
ensembl
ENSG00000274933
resolver
ensembl
ENSG00000275861
resolver
ensembl
ENSG00000282144
resolver
ensp
ENSP00000478225
resolver
ensp
ENSP00000478802
resolver
ensp
ENSP00000481258
resolver
enst
ENST00000618421
resolver
enst
ENST00000619234
resolver
enst
ENST00000621034
resolver
genesymbol
TBC1D3I
resolver
hgnc
HGNC:32709
resolver
uniprot_entry
TBC3I_HUMAN
resolver
amino_acid_sequence
MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKMKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF
uniprot
proteins
function
FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250|UniProtKB:Q8IZP1}.
uniprot
proteins
mass_dalton
62205
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation. {ECO:0000250|UniProtKB:Q8IZP1}.; PTM: Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination. {ECO:0000250|UniProtKB:Q8IZP1}.
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
21030649
uniprot
proteins
sequence_length
549
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IZP1}; Lipid-anchor {ECO:0000250|UniProtKB:Q8IZP1}. Note=Associated with lipid rafts. {ECO:0000250|UniProtKB:Q8IZP1}.
uniprot
proteins