FBXO11
entrez
80204
canonical
uniprot
Q86XK2
canonical
ensembl
ENSG00000138081
resolver
ensp
ENSP00000384823
resolver
ensp
ENSP00000385398
resolver
ensp
ENSP00000507789
resolver
ensp
ENSP00000565505
resolver
ensp
ENSP00000690591
resolver
enst
ENST00000683894
resolver
genesymbol
FBXO11
resolver
genesymbol_syn
FBX11
resolver
genesymbol_syn
PRMT9
resolver
genesymbol_syn
VIT1
resolver
hgnc
HGNC:13590
resolver
uniprot
A0A804HK63
resolver
uniprot
A1L491
resolver
uniprot
Q52ZP1
resolver
uniprot
Q53EP7
resolver
uniprot
Q53RT5
resolver
uniprot
Q8IXG3
resolver
uniprot
Q96E90
resolver
uniprot
Q9H6V8
resolver
uniprot
Q9H9L1
resolver
uniprot
Q9NR14
resolver
uniprot
Q9UFK1
resolver
uniprot
Q9UHI1
resolver
uniprot
Q9UKC2
resolver
uniprot_entry
A0A804HK63_HUMAN
resolver
uniprot_entry
FBX11_HUMAN
resolver
uniprot_sec
A1L491
resolver
uniprot_sec
Q52ZP1
resolver
uniprot_sec
Q53EP7
resolver
uniprot_sec
Q53RT5
resolver
uniprot_sec
Q8IXG3
resolver
uniprot_sec
Q96E90
resolver
uniprot_sec
Q9H6V8
resolver
uniprot_sec
Q9H9L1
resolver
uniprot_sec
Q9NR14
resolver
uniprot_sec
Q9UFK1
resolver
uniprot_sec
Q9UHI1
resolver
uniprot_sec
Q9UKC2
resolver
amino_acid_sequence
MNSVRAANRRPRRVSRPRPVQQQQQQPPQQPPPQPPQQQPPQQQPPPPPQQQQQQQPPPPPPPPPPLPQERNNVGERDDDVPADMVAEESGPGAQNSPYQLRRKTLLPKRTACPTKNSMEGASTSTTENFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAHVKPGFAEHFYSNPARYKGRENMLYYDTIEDALGGVQEAHFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQGACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGHGVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHPILRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQHN
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder with dysmorphic facies and behavioral abnormalities (IDDFBA) [MIM:618089]: An autosomal dominant developmental disorder with variable manifestations and onset in infancy or first years of life. Clinical features include intellectual disability, speech delay, hyperkinetic disorder, hyperactivity, seizures, pre- and postnatal growth retardation, microcephaly, and facial dysmorphism. {ECO:0000269|PubMed:27620904, ECO:0000269|PubMed:29796876, ECO:0000269|PubMed:30057029}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=Defects in FBXO11 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL6, an oncoprotein that has a critical role in lymphomas. {ECO:0000269|PubMed:22113614}.
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6, SNAI1 and PRDM1/BLIMP1 (PubMed:17098746, PubMed:22113614, PubMed:23478441, PubMed:23478445, PubMed:23892434, PubMed:24613396, PubMed:24968003, PubMed:25827072, PubMed:29059170). The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells (PubMed:22113614). The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit (PubMed:23478441, PubMed:23478445). The SCF(FBXO11) complex also catalyzes ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (PubMed:25827072, PubMed:29059170). Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity (PubMed:17098746). Plays a role in the regulatiom of erythropoiesis but not myelopoiesis or megakaryopoiesis (PubMed:33156908). Mechanistically, activates erythroid genes by mediating the degradation of BAHD1, a heterochromatin-associated protein that recruits corepressors to H3K27me3 marks (PubMed:33156908). Participates in macrophage cell death and inflammation in response to bacterial toxins by regulating the expression of complement 5a receptor 1/C5AR1 and IL-1beta (PubMed:33156908). Acts as a critical regulator to determine the level of MHC-II by mediating the recognition of degron at the P/S/T domain of CIITA leading to its ubiquitination and subsequent degradation via the proteasome (PubMed:37279268). Participates in the antiviral repsonse by initiating the activation of TBK1-IRF3-IFN-I axis (PubMed:36897010). Mediates the 'Lys-63'-linked ubiquitination of TRAF3 to strengthen the interaction between TRAF3 and TBK1 (PubMed:36897010). {ECO:0000269|PubMed:17098746, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23892434, ECO:0000269|PubMed:24613396, ECO:0000269|PubMed:24968003, ECO:0000269|PubMed:25827072, ECO:0000269|PubMed:29059170, ECO:0000269|PubMed:33156908, ECO:0000269|PubMed:36897010, ECO:0000269|PubMed:37279268}.
uniprot
proteins
mass_dalton
103585
uniprot
proteins
mutagenesis
MUTAGEN 575; /note="Q->L: Greatly reduced ability to bind PRDM1 and reduced proteolysis of PRDM1."; /evidence="ECO:0000269|PubMed:24613396
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:17098746, ECO:0000269|PubMed:25827072, ECO:0000269|PubMed:29059170}.
uniprot
proteins
pubmed
10531035
uniprot
proteins
pubmed
10531037
uniprot
proteins
pubmed
11775060
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16487488
uniprot
proteins
pubmed
17098746
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
22113614
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23478441
uniprot
proteins
pubmed
23478445
uniprot
proteins
pubmed
23892434
uniprot
proteins
pubmed
24613396
uniprot
proteins
pubmed
24968003
uniprot
proteins
pubmed
25827072
uniprot
proteins
pubmed
27620904
uniprot
proteins
pubmed
28097321
uniprot
proteins
pubmed
29059170
uniprot
proteins
pubmed
29796876
uniprot
proteins
pubmed
30057029
uniprot
proteins
pubmed
33156908
uniprot
proteins
pubmed
36897010
uniprot
proteins
pubmed
36977592
uniprot
proteins
pubmed
37279268
uniprot
proteins
sequence_length
927
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16487488, ECO:0000269|PubMed:17098746, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:25827072}. Chromosome {ECO:0000269|PubMed:23892434}.
uniprot
proteins