THOC5
entrez
8563
canonical
uniprot
Q13769
canonical
ensembl
ENSG00000100296
resolver
ensp
ENSP00000380969
resolver
ensp
ENSP00000380970
resolver
ensp
ENSP00000380971
resolver
ensp
ENSP00000420306
resolver
ensp
ENSP00000523474
resolver
ensp
ENSP00000523477
resolver
ensp
ENSP00000523480
resolver
ensp
ENSP00000598709
resolver
ensp
ENSP00000598711
resolver
ensp
ENSP00000627783
resolver
enst
ENST00000397871
resolver
enst
ENST00000397872
resolver
enst
ENST00000397873
resolver
enst
ENST00000490103
resolver
enst
ENST00000853415
resolver
enst
ENST00000853418
resolver
enst
ENST00000853421
resolver
enst
ENST00000928651
resolver
enst
ENST00000928652
resolver
genesymbol
THOC5
resolver
genesymbol_syn
C22orf19
resolver
genesymbol_syn
KIAA0983
resolver
hgnc
HGNC:19074
resolver
uniprot
O60839
resolver
uniprot
Q9UPZ5
resolver
uniprot_entry
THOC5_HUMAN
resolver
uniprot_sec
O60839
resolver
uniprot_sec
Q9UPZ5
resolver
amino_acid_sequence
MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTMGDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSASHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIVDAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSHR
uniprot
proteins
function
FUNCTION: Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Plays a key structural role in the oligomerization of the THO-DDX39B complex (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability (PubMed:18974867). Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes (PubMed:23685434). {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23685434, ECO:0000269|PubMed:33191911}.; FUNCTION: Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development. {ECO:0000250|UniProtKB:Q8BKT7}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}.
uniprot
proteins
mass_dalton
78508
uniprot
proteins
mutagenesis
MUTAGEN 225; /note="Y->F: Impairs mRNA binding, enhances CXCL12-dependent cell migration."; /evidence="ECO:0000269|PubMed:23032722
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine upon binding to activated CSF1R; which causes a dissociation of the two proteins. Phosphorylation on Ser-5 and/or Ser-6 is required for nuclear export. Phosphorylated on Thr-328 in insulin-stimulated adipocytes (By similarity). Phosphorylation at Tyr-225 modulates mRNA binding. {ECO:0000250, ECO:0000269|PubMed:18373705, ECO:0000269|PubMed:23032722}.
uniprot
proteins
protein_family
THOC5 family
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15833825
uniprot
proteins
pubmed
15998806
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17190602
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18373705
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18974867
uniprot
proteins
pubmed
19059247
uniprot
proteins
pubmed
19165146
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22144908
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22893130
uniprot
proteins
pubmed
23032722
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23299939
uniprot
proteins
pubmed
23685434
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25662211
uniprot
proteins
pubmed
26382858
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
33191911
uniprot
proteins
pubmed
37020021
uniprot
proteins
pubmed
8242058
uniprot
proteins
sequence_length
683
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19059247, ECO:0000269|PubMed:19165146}. Cytoplasm {ECO:0000269|PubMed:19059247}. Note=Shuttles between nucleus and cytoplasm. {ECO:0000269|PubMed:19059247}.
uniprot
proteins