Trpv4
entrez
63873
canonical
uniprot
Q9EPK8
canonical
ensembl
ENSMUSG00000014158
resolver
ensp
ENSMUSP00000071859
resolver
ensp
ENSMUSP00000107844
resolver
ensp
ENSMUSP00000173541
resolver
enst
ENSMUST00000071968
resolver
enst
ENSMUST00000112225
resolver
genesymbol
Trpv4
resolver
genesymbol_syn
Trp12
resolver
genesymbol_syn
Vrl2
resolver
genesymbol_syn
Vroac
resolver
uniprot
A0JNY0
resolver
uniprot
Q91XR5
resolver
uniprot
Q9EQZ4
resolver
uniprot
Q9ERZ7
resolver
uniprot
Q9ES76
resolver
uniprot_entry
TRPV4_MOUSE
resolver
uniprot_sec
A0JNY0
resolver
uniprot_sec
Q91XR5
resolver
uniprot_sec
Q9EQZ4
resolver
uniprot_sec
Q9ERZ7
resolver
uniprot_sec
Q9ES76
resolver
amino_acid_sequence
MADPGDGPRAAPGEVAEPPGDESGTSGGEAFPLSSLANLFEGEEGSSSLSPVDASRPAGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDNKRWRRKVVEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLSFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTSLHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCSRLFPDSNLETVLNNDGLSPLMMAAKTGKIGVFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEVSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTSIKDLFTKKCPGVNSLFVDGSFQLLYFIYSVLVVVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVTLLNPCTNMKVCDEDQSNCTVPTYPACRDSETFSAFLLDLFKLTIGMGDLEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKSEIYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSSADEVVVPLDNLGNPNCDGHQQGYAPKWRTDDAPL
uniprot
proteins
function
FUNCTION: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:11094154, PubMed:12093812, PubMed:12538589). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:12093812, PubMed:14691263, PubMed:16368742, PubMed:16571723). Also activated by heat, low pH, citrate and phorbol esters (PubMed:14691263). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (By similarity). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (By similarity). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (PubMed:20413591). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (PubMed:23021218). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (PubMed:23021218). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Required for normal development and maintenance of bone and cartilage (By similarity). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (By similarity). In neurons of the central nervous system, could play a role in triggering voluntary water intake in response to increased sodium concentration in body fluid (PubMed:27252474). {ECO:0000250|UniProtKB:Q9HBA0, ECO:0000269|PubMed:11094154, ECO:0000269|PubMed:12093812, ECO:0000269|PubMed:12538589, ECO:0000269|PubMed:14691263, ECO:0000269|PubMed:16368742, ECO:0000269|PubMed:16571723, ECO:0000269|PubMed:18174177, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:20413591, ECO:0000269|PubMed:23021218, ECO:0000269|PubMed:27252474}.
uniprot
proteins
mass_dalton
98027
uniprot
proteins
mutagenesis
MUTAGEN 110; /note="Y->F: Increases protein abundance at plasma membrane. Greatly reduces channel activity."; /evidence="ECO:0000269|PubMed:19033444"; MUTAGEN 142..143; /note="PP->AL: Strongly reduced interaction with PACSIN3."; /evidence="ECO:0000269|PubMed:16627472"; MUTAGEN 253; /note="Y->F: Results are conflicting as to whether hypotonicity-dependent channel activity is abolished."; /evidence="ECO:0000269|PubMed:12538589, ECO:0000269|PubMed:14691263"; MUTAGEN 556; /note="Y->A: Reduces channel activation by 4-alpha-PDD and heat but not hypo-osmotic cell swelling."; /evidence="ECO:0000269|PubMed:14691263"; MUTAGEN 556; /note="Y->F: No changes in channel activation by 4-alpha-PDD or heat."; /evidence="ECO:0000269|PubMed:14691263"; MUTAGEN 557; /note="S->A: No changes in channel activity."; /evidence="ECO:0000269|PubMed:14691263"; MUTAGEN 651; /note="N->Q: Loss of a probable N-glycosylation site. Increased expression at the cell membrane, leading to increased ion currents."; /evidence="ECO:0000269|PubMed:16368742"; MUTAGEN 672; /note="D->A: Greatly reduces Ca(2+) permeation and channel rectification; when associated with A-682."; /evidence="ECO:0000269|PubMed:12093812"; MUTAGEN 675; /note="K->A: No effect on channel pore properties."; /evidence="ECO:0000269|PubMed:12093812"; MUTAGEN 680; /note="M->A: Impairs Ca(2+) permeation."; /evidence="ECO:0000269|PubMed:12093812"; MUTAGEN 682; /note="D->A: Greatly reduces Ca(2+) permeation and channel rectification; when associated with A-672."; /evidence="ECO:0000269|PubMed:12093812"; MUTAGEN 805; /note="Y->F: No changes in channel activity."; /evidence="ECO:0000269|PubMed:19033444"; MUTAGEN 824; /note="S->A: Loss of phosphorylation but no significant effect on channel activity."; /evidence="ECO:0000269|PubMed:20043876"; MUTAGEN 824; /note="S->D: Phosphomimetic mutant which enhances channel function."; /evidence="ECO:0000269|PubMed:20043876
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000305|PubMed:16368742}.
uniprot
proteins
protein_family
TRPV4 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
protein_family
TrpV subfamily
uniprot
proteins
pubmed
11025659
uniprot
proteins
pubmed
11081638
uniprot
proteins
pubmed
11094154
uniprot
proteins
pubmed
12093812
uniprot
proteins
pubmed
12538589
uniprot
proteins
pubmed
12692122
uniprot
proteins
pubmed
14517216
uniprot
proteins
pubmed
14691263
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16368742
uniprot
proteins
pubmed
16571723
uniprot
proteins
pubmed
16627472
uniprot
proteins
pubmed
18174177
uniprot
proteins
pubmed
18695040
uniprot
proteins
pubmed
19033444
uniprot
proteins
pubmed
20043876
uniprot
proteins
pubmed
20413591
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23021218
uniprot
proteins
pubmed
24509911
uniprot
proteins
pubmed
27252474
uniprot
proteins
sequence_length
871
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11094154, ECO:0000269|PubMed:14691263, ECO:0000269|PubMed:16571723, ECO:0000269|PubMed:16627472, ECO:0000269|PubMed:20413591, ECO:0000269|PubMed:24509911}. Apical cell membrane {ECO:0000269|PubMed:14691263, ECO:0000269|PubMed:16571723, ECO:0000269|PubMed:16627472, ECO:0000269|PubMed:24509911, ECO:0000305|PubMed:12093812, ECO:0000305|PubMed:16368742}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9HBA0}. Cell junction, adherens junction {ECO:0000269|PubMed:20413591}. Cell projection, cilium {ECO:0000269|PubMed:18695040}. Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. Localization to the cell membrane is inhibited by WNK kinases (WNK1, WNK2, WNK3 or WNK4) in a kinase-independent mechanism. {ECO:0000250|UniProtKB:Q9HBA0}.
uniprot
proteins
transmembrane_region
TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O35433"; TRANSMEM 508..534; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O35433"; TRANSMEM 548..568; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O35433"; TRANSMEM 573..593; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O35433"; TRANSMEM 609..636; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O35433"; TRANSMEM 694..722; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O35433
uniprot
proteins