Stk38l
entrez
232533
canonical
uniprot
Q7TSE6
canonical
ensembl
ENSMUSG00000001630
resolver
ensp
ENSMUSP00000001675
resolver
ensp
ENSMUSP00000107271
resolver
ensp
ENSMUSP00000211847
resolver
genesymbol
Stk38l
resolver
genesymbol_syn
Ndr2
resolver
uniprot
B2KFR4
resolver
uniprot
Q6P6K6
resolver
uniprot
Q8BWK4
resolver
uniprot_entry
ST38L_MOUSE
resolver
uniprot_sec
B2KFR4
resolver
uniprot_sec
Q6P6K6
resolver
uniprot_sec
Q8BWK4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2 to the N-terminal of STK38L (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MAMTAGATTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKADMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDVKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGFPPFCSETPQETYRKVMSWKETLAFPPEVPVSEKAKDLILRFCTDSENRIGNGGVEEIKGHPFFEGVDWGHIRERPAAIPIEIRSIDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Involved in the regulation of structural processes in differentiating and mature neuronal cells. {ECO:0000269|PubMed:15308672, ECO:0000269|PubMed:21730291}.
uniprot
proteins
mass_dalton
53772
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15037617
uniprot
proteins
pubmed
15308672
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21730291
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15308672}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15308672}. Membrane {ECO:0000269|PubMed:15308672}. Note=Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.
uniprot
proteins