SEPTIN11
entrez
55752
canonical
uniprot
Q9NVA2
canonical
ensembl
ENSG00000138758
resolver
ensp
ENSP00000264893
resolver
ensp
ENSP00000422896
resolver
ensp
ENSP00000663433
resolver
ensp
ENSP00000663434
resolver
genesymbol
SEPTIN11
resolver
genesymbol_syn
SEPT11
resolver
hgnc
HGNC:25589
resolver
uniprot
A0A384P5S0
resolver
uniprot
B7Z7Z6
resolver
uniprot
E9KL32
resolver
uniprot
Q4W5G1
resolver
uniprot
Q7L4N1
resolver
uniprot
Q96SP1
resolver
uniprot
Q9UFY9
resolver
uniprot_entry
A0A384P5S0_HUMAN
resolver
uniprot_entry
SEP11_HUMAN
resolver
uniprot_sec
B7Z7Z6
resolver
uniprot_sec
E9KL32
resolver
uniprot_sec
Q4W5G1
resolver
uniprot_sec
Q7L4N1
resolver
uniprot_sec
Q96SP1
resolver
uniprot_sec
Q9UFY9
resolver
amino_acid_sequence
MAVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPTDEETVAEINATMSVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVMRVKEKEAELKEAEKELHEKFDLLKRTHQEEKKKVEDKKKELEEEVNNFQKKKAAAQLLQSQAQQSGAQQTKKDKDKKNASFT
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving SEPTIN11 may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with KMT2A/MLL1.
uniprot
proteins
function
FUNCTION: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. {ECO:0000250, ECO:0000269|PubMed:15196925, ECO:0000269|PubMed:19234302, ECO:0000305}.
uniprot
proteins
mass_dalton
49398
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="G->A: High reduction in GTPase activity. No effect on GTP-binding. Loss of filament formation."; /evidence="ECO:0000269|PubMed:15196925
uniprot
proteins
protein_family
Septin GTPase family
uniprot
proteins
protein_family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14999297
uniprot
proteins
pubmed
15196925
uniprot
proteins
pubmed
15485874
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15915442
uniprot
proteins
pubmed
17546647
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18047794
uniprot
proteins
pubmed
19145258
uniprot
proteins
pubmed
19234302
uniprot
proteins
pubmed
20736409
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
429
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Synapse. Cell projection, dendritic spine. Cell projection, axon {ECO:0000250}. Note=Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
uniprot
proteins