HSPA2
entrez
3306
canonical
uniprot
P54652
canonical
ensembl
ENSG00000126803
resolver
ensp
ENSP00000247207
resolver
ensp
ENSP00000378199
resolver
enst
ENST00000247207
resolver
enst
ENST00000394709
resolver
genesymbol
HSPA2
resolver
hgnc
HGNC:5235
resolver
uniprot
Q15508
resolver
uniprot
Q53XM3
resolver
uniprot
Q9UE78
resolver
uniprot_entry
HSP72_HUMAN
resolver
uniprot_sec
Q15508
resolver
uniprot_sec
Q53XM3
resolver
uniprot_sec
Q9UE78
resolver
amino_acid_sequence
MSARGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEIAEAYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDLLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQEAERYKSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQMAEKDEYEHKQKELERVCNPIISKLYQGGPGGGSGGGGSGASGGPTIEEVD
uniprot
proteins
function
FUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}.
uniprot
proteins
mass_dalton
70021
uniprot
proteins
mutagenesis
MUTAGEN 564; /note="K->A: Abolishes methylation by METTL21A."; /evidence="ECO:0000269|PubMed:23921388
uniprot
proteins
protein_family
Heat shock protein 70 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18529014
uniprot
proteins
pubmed
20072699
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23921388
uniprot
proteins
pubmed
26865365
uniprot
proteins
pubmed
7829106
uniprot
proteins
pubmed
7849706
uniprot
proteins
sequence_length
639
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P17156}. Note=Colocalizes with SHCBP1L at spindle during the meiosis process. {ECO:0000250|UniProtKB:P17156}.
uniprot
proteins