Foxa2
entrez
15376
canonical
uniprot
P35583
canonical
ensembl
ENSMUSG00000037025
resolver
ensp
ENSMUSP00000045918
resolver
ensp
ENSMUSP00000105590
resolver
enst
ENSMUST00000047315
resolver
enst
ENSMUST00000109964
resolver
genesymbol
Foxa2
resolver
genesymbol_syn
Hnf3b
resolver
genesymbol_syn
Tcf-3b
resolver
genesymbol_syn
Tcf3b
resolver
uniprot
A2AR89
resolver
uniprot
G5E8P5
resolver
uniprot
Q60602
resolver
uniprot_entry
FOXA2_MOUSE
resolver
uniprot_entry
G5E8P5_MOUSE
resolver
uniprot_sec
A2AR89
resolver
uniprot_sec
Q60602
resolver
amino_acid_sequence
MLGAVKMEGHEPSDWSSYYAEPEGYSSVSNMNAGLGMNGMNTYMSMSAAAMGGGSGNMSAGSMNMSSYVGAGMSPSLAGMSPGAGAMAGMSGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKQLALKEAAGAASSGGKKTAPGSQASQAQLGEAAGSASETPAGTESPHSSASPCQEHKRGGLSELKGAPASALSPPEPAPSPGQQQQAAAHLLGPPHHPGLPPEAHLKPEHHYAFNHPFSINNLMSSEQQHHHSHHHHQPHKMDLKAYEQVMHYPGGYGSPMPGSLAMGPVTNKAGLDASPLAADTSYYQGVYSRPIMNSS
uniprot
proteins
function
FUNCTION: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; Foxa1 and Foxa2 seem to have at least in part redundant roles. FOXA1 and FOXA2 are essential for hepatic specification. FOXA1 and FOXA2 are required for morphogenesis and cell differentiation during formation of the lung. FOXA1 and FOXA2 are involved in bile duct formation; they positively regulate the binding glucocorticoid receptor/NR3C1 to the IL6 promoter. FOXA1 and FOXA2 regulate multiple phases of midbrain dopaminergic neuron development; they regulate expression of NEUROG2 at the beginning of mDA neurogenesis and of NR4A2 and EN1 in immature mDA neurons. Modulates the transcriptional activity of nuclear hormone receptors; inhibits AR-mediated transcription from the LCN5 promoter. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. In pancreatic beta cells activates transcription of potassium channel subunits KCNJ11 and ABCC8. Involved in regulation of fat metabolism; activates transcriptional programs of lipid metabolism and ketogenesis at low insulin state. Involved in transcriptional regulation of MUC2 in the intestine. {ECO:0000250, ECO:0000269|PubMed:11445544, ECO:0000269|PubMed:11875061, ECO:0000269|PubMed:15616563, ECO:0000269|PubMed:15668254, ECO:0000269|PubMed:15959514, ECO:0000269|PubMed:16740652, ECO:0000269|PubMed:17596284, ECO:0000269|PubMed:18336786, ECO:0000269|PubMed:19141476, ECO:0000269|PubMed:19436110, ECO:0000269|PubMed:8069909}.
uniprot
proteins
mass_dalton
48498
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation. {ECO:0000250}.
uniprot
proteins
pubmed
11445544
uniprot
proteins
pubmed
11875061
uniprot
proteins
pubmed
14500912
uniprot
proteins
pubmed
15616563
uniprot
proteins
pubmed
15668254
uniprot
proteins
pubmed
15959514
uniprot
proteins
pubmed
16740652
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17596284
uniprot
proteins
pubmed
18336786
uniprot
proteins
pubmed
19141476
uniprot
proteins
pubmed
19436110
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8034310
uniprot
proteins
pubmed
8069909
uniprot
proteins
pubmed
8306889
uniprot
proteins
pubmed
8375339
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:15616563}. Cytoplasm {ECO:0000269|PubMed:15616563}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
uniprot
proteins