LDLRAD3
entrez
143458
canonical
uniprot
Q86YD5
canonical
ensembl
ENSG00000179241
resolver
ensp
ENSP00000318607
resolver
ensp
ENSP00000433954
resolver
genesymbol
LDLRAD3
resolver
genesymbol_syn
LRAD3
resolver
hgnc
HGNC:27046
resolver
uniprot
B7Z1U3
resolver
uniprot
B9EG81
resolver
uniprot
Q8NBJ0
resolver
uniprot_entry
LRAD3_HUMAN
resolver
uniprot_sec
B7Z1U3
resolver
uniprot_sec
B9EG81
resolver
uniprot_sec
Q8NBJ0
resolver
amino_acid_sequence
MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGIQYVASQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSANSASSQAASSLLSVEDTSHSPGQPGPQEGTAEPRDSEPSQGTEEV
uniprot
proteins
function
FUNCTION: May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed:26854353). {ECO:0000250, ECO:0000269|PubMed:26854353}.; FUNCTION: (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus. {ECO:0000269|PubMed:33208938, ECO:0000269|PubMed:34646020, ECO:0000269|PubMed:34646021}.
uniprot
proteins
mass_dalton
37419
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="G->D: Loss of infection by Venezuelan equine encephalitis virus."; /evidence="ECO:0000269|PubMed:34646020"; MUTAGEN 36; /note="M->T: Loss of infection by Venezuelan equine encephalitis virus."; /evidence="ECO:0000269|PubMed:34646020"; MUTAGEN 44; /note="P->R: Loss of infection by Venezuelan equine encephalitis virus."; /evidence="ECO:0000269|PubMed:34646020"; MUTAGEN 47; /note="W->G,I: Complete loss of interaction with Venezuelan equine encephalitis virus/VEEV spike proteins E1."; /evidence="ECO:0000269|PubMed:34646021"; MUTAGEN 50; /note="D->G: Loss of infection by Venezuelan equine encephalitis virus."; /evidence="ECO:0000269|PubMed:34646021"; MUTAGEN 57; /note="D->G: Complete loss of interaction with Venezuelan equine encephalitis virus/VEEV spike proteins E1."; /evidence="ECO:0000269|PubMed:34646021"; MUTAGEN 57; /note="D->V: Loss of infection by Venezuelan equine encephalitis virus."; /evidence="ECO:0000269|PubMed:34646020"; MUTAGEN 257; /note="P->A: Does not affect interaction with ITCH; when associated with A-259. Loss of interaction with ITCH; when associated with A-259; A-276; A-277 and A-278."; /evidence="ECO:0000269|PubMed:26854353"; MUTAGEN 259; /note="Y->A: Does not affect interaction with ITCH; when associated with A-257. Loss of interaction with ITCH; when associated with A-257; A-276; A-277 and A-278."; /evidence="ECO:0000269|PubMed:26854353"; MUTAGEN 276; /note="P->A: Does not affect interaction with ITCH; when associated with A-277 and A-278. Loss of interaction with ITCH; when associated with A-257; A-259; A-277 and A-278."; /evidence="ECO:0000269|PubMed:26854353"; MUTAGEN 277; /note="P->A: Does not affect interaction with ITCH; when associated with A-276 and A-278. Loss of interaction with ITCH; when associated with A-257; A-259; A-276 and A-278."; /evidence="ECO:0000269|PubMed:26854353"; MUTAGEN 278; /note="Y->A: Does not affect interaction with ITCH; when associated with A-276 and A-277. Loss of interaction with ITCH; when associated with A-257; A-259; A-276 and A-277."; /evidence="ECO:0000269|PubMed:26854353
uniprot
proteins
protein_family
LDLR family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
21795536
uniprot
proteins
pubmed
26854353
uniprot
proteins
pubmed
33208938
uniprot
proteins
pubmed
34646020
uniprot
proteins
pubmed
34646021
uniprot
proteins
sequence_length
345
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:33208938, ECO:0000269|PubMed:34646020, ECO:0000269|PubMed:34646021}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 174..194; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins