SUPT4H1
entrez
6827
canonical
uniprot
P63272
canonical
ensembl
ENSG00000213246
resolver
ensp
ENSP00000225504
resolver
ensp
ENSP00000462670
resolver
enst
ENST00000225504
resolver
enst
ENST00000580947
resolver
genesymbol
SUPT4H1
resolver
genesymbol_syn
SPT4H
resolver
genesymbol_syn
SUPT4H
resolver
hgnc
HGNC:11467
resolver
uniprot
B2R4X8
resolver
uniprot
D3DTZ4
resolver
uniprot
Q16550
resolver
uniprot
Q62387
resolver
uniprot
Q6ZP89
resolver
uniprot_entry
SPT4H_HUMAN
resolver
uniprot_sec
B2R4X8
resolver
uniprot_sec
D3DTZ4
resolver
uniprot_sec
Q16550
resolver
uniprot_sec
Q62387
resolver
uniprot_sec
Q6ZP89
resolver
amino_acid_sequence
MALETVPKDLRHLRACLLCSLVKTIDQFEYDGCDNCDAYLQMKGNREMVYDCTSSSFDGIIAMMSPEDSWVSKWQRVSNFKPGVYAVSVTGRLPQGIVRELKSRGVAYKSRDTAIKT
uniprot
proteins
function
FUNCTION: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10454543, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:15136722). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10199401, PubMed:10912001, PubMed:11112772). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10199401, PubMed:10912001, PubMed:11112772). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:10199401, PubMed:10912001, PubMed:11112772). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:11112772). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9857195}.
uniprot
proteins
mass_dalton
13193
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by UBR5 when not assembled in the DSIF complex, leading to its degradation: UBR5 recognizes and binds a degron that is not accessible when SUPT4H1 is part of the DSIF complex. {ECO:0000269|PubMed:37478862}.
uniprot
proteins
protein_family
SPT4 family
uniprot
proteins
pubmed
10075709
uniprot
proteins
pubmed
10199401
uniprot
proteins
pubmed
10454543
uniprot
proteins
pubmed
10757782
uniprot
proteins
pubmed
10912001
uniprot
proteins
pubmed
11112772
uniprot
proteins
pubmed
11553615
uniprot
proteins
pubmed
12653964
uniprot
proteins
pubmed
12718890
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15060154
uniprot
proteins
pubmed
15136722
uniprot
proteins
pubmed
15380072
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16214896
uniprot
proteins
pubmed
19860741
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
28892040
uniprot
proteins
pubmed
37478862
uniprot
proteins
pubmed
8649394
uniprot
proteins
pubmed
8786137
uniprot
proteins
pubmed
9450929
uniprot
proteins
pubmed
9857195
uniprot
proteins
sequence_length
117
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8649394}.
uniprot
proteins