Q8K3H5
uniprot
Q8K3H5
canonical
amino_acid_sequence
MLPLIGKTIIFDNFPDPSDTWEIIETIGKGTYGKVFKVLNKKSGQKAAVKILDPIHDIDEEIEAEYNILRTLSDHPNVVRFYGIYFKKDKINGDKLWLVLELCNGGSVTDLVKGFLKRGERMSEPVIAYILHEALMGLQHLHSNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLSSTRHRLNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLAELHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSDLLKHKFITQIEGKDVILQKQLMEFIDIHQCLGSTEKARHERIHTKKGNLNRSLISSLKDVDDLATLDVLDEPTASPHLHPCHSRDQIHIHVADILIALNPFQSLGIYSPKLSRLYIGAKRTANPPHIFAMADLGYQSMVTYNADQCIVISGESGAGKTESAHLLVQQLTVLGKANNRTLQEKILQMNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEKSRVIHQAMGEKNFHIFYYIYGGLAEKKKLALYKSPEHKPPRYLQNDNLRTVQDMMNNSFYKSQYELIEQCFKVIGFTMEQLASVYSVLAAILNVGNIEFSSVATEYQMDKSYICNHTALENCASLLCIQADELQEALTSHCVVTRGETIIRPNTVEKAADVRDAMAKTLYGRLFSCIVNCINSLLKHDTSPSGDEELNIGILDIFGFENFKRNSFEQLCINIANEQIQYYFNQHVFAWEQNEYLNEDVDARVIEYEDNRPLLDMFLQKPMGLLSLLDEESRFPKATDQTLIEKFEDNLKSQYFWRPKRMELSFGIHHYAGKVLYSASGFLAKNRDTFPTDIVLPLRSSENSVIRQLVNHPLTKTGNLPLSKTKNIVNYQMWNSEKSTNLTKGETRDVTCHACETTNVKTQTVSSYFRYSLMDLLSKMVVGQPHFVRCIKPNNERQARKYDKEKVLLQLRCTGILETARIRRLGYSHRILFANFIKRYYILCYKSSEEPPVSPDTCAAILEKAGLDNWALGKTKVFLKYYHVEQLNLMRKEATNKLVLIQASVRAFLGARRYQELQQKRKSSAVIIQSAARGHLVRKQRKEIVDMKNTAVTTIQTSDQEFDYKKNFENTRESFVKKQTENAVPTNESNTSTPNNKESPSAGKTAPFIAESKATNVESNNRRYHTQKKMSNVYAEGQNQELYIVEDTWAEVSPRQKYVQDLEESRKMRKEEKGDAVIQSYCQWYTEGSNFEESKATCLEGRETWERTSCPGLWLTEEIYLRKTLDPTLSQKSVYQNADGKEKEHKVSVVTQNAPLGNLERDYHLLGFLGEEDTGPVPQAQEEHKAVSIHSKYQSSKKKQQLGKDRLAPPFKNQKILSSSTEVAKTTHNVYPCPTKQEGVHHSKMVDERDSKMASKKEAWDLAMFSRQISKLSEEYFILQKNLNEIILAQQLKPFYLGIYRHKPINRHVSTHQYLSGVSKGEEPKILRPPRRPRKPKTLNNPEDSTYYYLLHKSTQEEKRRPGKDSQGKLLGLEDFYYKEFLPTHYGPKAHSSNAREWKALKEPQAQPIESNERCWTTSENESLEEERISANPYDYRRLLRKTSQRQRLVQQL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Actin-dependent motor protein with a protein kinase activity, playing an essential role in hearing (PubMed:26754646). Probably plays also a role in vision (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern (PubMed:26754646). Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (PubMed:19287378). {ECO:0000250|UniProtKB:Q8NEV4, ECO:0000269|PubMed:19287378, ECO:0000269|PubMed:26754646}.
uniprot
proteins
mass_dalton
184730
uniprot
proteins
protein_family
Myosin family; Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
12032315
uniprot
proteins
pubmed
19287378
uniprot
proteins
pubmed
26754646
uniprot
proteins
pubmed
26926603
uniprot
proteins
sequence_length
1613
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm {ECO:0000269|PubMed:26754646}. Cell projection, filopodium tip {ECO:0000250|UniProtKB:Q8NEV4}. Cell projection, stereocilium {ECO:0000269|PubMed:26754646}. Note=Increased localization at the filodium tip seen in the presence of MORN4. {ECO:0000250|UniProtKB:Q8NEV4}.
uniprot
proteins