Lclat1
entrez
225010
canonical
uniprot
Q3UN02
canonical
ensembl
ENSMUSG00000054469
resolver
ensp
ENSMUSP00000068690
resolver
ensp
ENSMUSP00000258900
resolver
ensp
ENSMUSP00000258908
resolver
enst
ENSMUST00000067545
resolver
genesymbol
Lclat1
resolver
genesymbol_syn
Agpat8
resolver
genesymbol_syn
Alcat1
resolver
genesymbol_syn
Gm91
resolver
genesymbol_syn
Lycat
resolver
uniprot
B0V2Q7
resolver
uniprot_entry
B0V2Q7_MOUSE
resolver
uniprot_entry
LCLT1_MOUSE
resolver
amino_acid_sequence
MVSWKGIYFILFLFAGSFFGSIFMLGPILPLMFINLSWYRWISSRLVATWLTLPVALLETMFGVRVVITGDAFVPGERSVIIMNHRTRVDWMFLWNCLMRYSYLRVEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSHFEDMIDYFCAIHEPLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLREGKNLDAVHDITVAYPYNIPQTEKHLLLGDFPKEIHFHVQRYPADSLPTSKEDLQLWCHRRWEEKEERLRSFYQGEKNFHFTGQSTVPPCKSELRVLVVKLLSIVYWALFCSAMCLLIYLYSPVRWYFIISIVFFVLQERIFGGLEIIELACYRFLHKHPHLNSKKNE
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.51
uniprot
proteins
function
FUNCTION: Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (PubMed:15152008). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (PubMed:15152008). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Possesses lysophosphatidylinositol acyltransferase (LPIAT) activity (PubMed:20668164). Possesses lysophosphatidylglycerol acyltransferase (LPGAT) activity (By similarity). Required for establishment of the hematopoietic and endothelial lineages (PubMed:17675553). {ECO:0000250|UniProtKB:Q6UWP7, ECO:0000269|PubMed:15152008, ECO:0000269|PubMed:17675553, ECO:0000269|PubMed:20668164}.
uniprot
proteins
mass_dalton
44400
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
uniprot
proteins
protein_family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
uniprot
proteins
pubmed
15152008
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16620771
uniprot
proteins
pubmed
17675553
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20668164
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15152008}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 48..68; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 309..329; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 336..356; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins