Mbd6
entrez
110962
canonical
uniprot
Q3TY92
canonical
ensembl
ENSMUSG00000025409
resolver
ensp
ENSMUSP00000026476
resolver
ensp
ENSMUSP00000112805
resolver
ensp
ENSMUSP00000253157
resolver
ensp
ENSMUSP00000342257
resolver
ensp
ENSMUSP00000342258
resolver
enst
ENSMUST00000026476
resolver
enst
ENSMUST00000119078
resolver
genesymbol
Mbd6
resolver
genesymbol_syn
D10Wsu93e
resolver
uniprot
E9PWH8
resolver
uniprot
E9Q572
resolver
uniprot
Q4VBD6
resolver
uniprot
Q5XJH3
resolver
uniprot_entry
E9Q572_MOUSE
resolver
uniprot_entry
MBD6_MOUSE
resolver
uniprot_entry
Q4VBD6_MOUSE
resolver
uniprot_entry
Q5XJH3_MOUSE
resolver
uniprot_sec
E9PWH8
resolver
amino_acid_sequence
MNGDNASSAADRAGGPAATPVPIPIGWQRCVREGAVYYISPSGTELSSLEQTRSYLLSDGTCKCGLECPLNVPKVFNFDPLAPVTPGGAGVGPASEEDMTKLCNHRRKAVAMATLYRSMETTCSHSSPGEGASPQMFHTVSPGPPSVRPPCRAPPTTPLNGGPGSIPQDPPSVPQAFPPLTGPAGLFPPPRLPDPVPSAGSSSPCFLPRGNAPSPAPPPPPAISLNAPSYNWGASLRSNLVPSDLGSPPAPHASSSPPSDSPLFHCSDALTSPPLPPSNNPPGPPGPPGPATQPPVSSATMHLPLVLGSLGGAPAVEGPGAPPFLASSLLSAAAKAQLPPPSTLQGRRPRAQAPSAAHASPRPSQRRPRRPPTVLRLLEGGGPQTPRRTRPRAPAPVPQPFPLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPALSSGSPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSPSDGLGMGAGPACPLPPLAGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPSPFLSHSLFGVLAGGGQPPPEPLLPPPGGPGPPSAPGEPEGPSLLVASLLSPPPSDLLPPPSAPPSNLLASFLPLLALGPTAGDGEGSAEGAGGPNGEPFSGLGDLPPLLFPPLSAPPTLIALNSALLAASLDPPSGTPPQPCVLSAPQPGPPTSSVTTATTDPGASSLGKAPSNSGRPQLLSPLLSASLLGDLSSLASSPGALPSLLQPPGPLLSSQLGLQLLPGGGAPPALSEASSPLACLLQSLQIPPEQPDAPCLPPESPASALEPEPARPPLSALAPPHASPDPPVPELLTGRGSGKRGRRGGGGLRGINGETRPGRGRKPGSRREPGRLALKWGTRGGFNGQMERSPRRTHHWQHNGELAEGGAEPKDPPLPGTHSEDLKVPPGIVRKSRRGRRRKYNPARNSSSSRQDVTLEPSPTTRAAVPLPPRARPGRPAKNKRRKLAP
uniprot
proteins
function
FUNCTION: Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1). Important for stability of PR-DUB components and stimulating its ubiquitinase activity. As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3. MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways. Heterochromatin recruitment is not mediated by DNA methylation. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability; may promote cancer cell growth. {ECO:0000250|UniProtKB:Q96DN6}.
uniprot
proteins
mass_dalton
100990
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20700456
uniprot
proteins
sequence_length
1003
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96DN6}. Chromosome {ECO:0000250|UniProtKB:Q96DN6}. Note=Associates with heterochromatin containing chromocentres in a subset of cells in a DNA methylation-independent manner. Localizes to sites of DNA damage independent of the PR-DUB complex. {ECO:0000250|UniProtKB:Q96DN6}.
uniprot
proteins