MCHR2
entrez
84539
canonical
uniprot
Q969V1
canonical
ensembl
ENSG00000152034
resolver
ensp
ENSP00000281806
resolver
ensp
ENSP00000358214
resolver
ensp
ENSP00000550296
resolver
enst
ENST00000281806
resolver
enst
ENST00000369212
resolver
enst
ENST00000880237
resolver
genesymbol
MCHR2
resolver
genesymbol_syn
GPR145
resolver
genesymbol_syn
SLT
resolver
hgnc
HGNC:20867
resolver
uniprot
B3KVW4
resolver
uniprot
E1P5D7
resolver
uniprot
Q5VTV7
resolver
uniprot
Q6Q377
resolver
uniprot
Q9BXA8
resolver
uniprot_entry
MCHR2_HUMAN
resolver
uniprot_sec
B3KVW4
resolver
uniprot_sec
E1P5D7
resolver
uniprot_sec
Q5VTV7
resolver
uniprot_sec
Q6Q377
resolver
uniprot_sec
Q9BXA8
resolver
amino_acid_sequence
MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for the neuropeptide melanin-concentrating hormone (MCH). Upon ligand binding, couples to G(q/11), leading to activation of phospholipase C and intracellular calcium mobilization (PubMed:11274220, PubMed:11404457, PubMed:11459838, PubMed:15340116, PubMed:38710677). The physiological roles mediated by this receptor remain unclear, and its contribution to specific biological processes has not been conclusively established (Probable). Expression of this receptor is restricted to the brain of non-rodent mammals; a functional MCHR2 gene is absent or pseudogenized in rodents (By similarity). {ECO:0000250|UniProtKB:Q8MJ88, ECO:0000269|PubMed:11274220, ECO:0000269|PubMed:11404457, ECO:0000269|PubMed:11459838, ECO:0000269|PubMed:15340116, ECO:0000269|PubMed:38710677, ECO:0000305}.
uniprot
proteins
mass_dalton
38849
uniprot
proteins
mutagenesis
MUTAGEN 82; /note="H->A: Loss of MCH-induced Gq activity."; /evidence="ECO:0000269|PubMed:38710677"; MUTAGEN 97; /note="G->A: Loss of MCH-induced Gq activity."; /evidence="ECO:0000269|PubMed:38710677"; MUTAGEN 184; /note="C->A: Loss of MCH-induced Gq activity."; /evidence="ECO:0000269|PubMed:38710677"; MUTAGEN 185; /note="A->W: Loss of MCH-induced Gq activity."; /evidence="ECO:0000269|PubMed:38710677"; MUTAGEN 268; /note="H->F: Loss of MCH-induced Gq activity."; /evidence="ECO:0000269|PubMed:38710677"; MUTAGEN 296; /note="Y->A: Loss of MCH-induced Gq activity."; /evidence="ECO:0000269|PubMed:38710677
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11274220
uniprot
proteins
pubmed
11355873
uniprot
proteins
pubmed
11404457
uniprot
proteins
pubmed
11459838
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340116
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
38710677
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:38710677}; Multi-pass membrane protein {ECO:0000269|PubMed:38710677}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 70..90; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 105..129; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 253..273; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins