MCHR1
entrez
2847
canonical
uniprot
Q99705
canonical
ensembl
ENSG00000128285
resolver
ensp
ENSP00000249016
resolver
enst
ENST00000249016
resolver
genesymbol
MCHR1
resolver
genesymbol_syn
GPR24
resolver
genesymbol_syn
SLC1
resolver
hgnc
HGNC:4479
resolver
uniprot
B2RBX6
resolver
uniprot
Q5R3J1
resolver
uniprot
Q96S47
resolver
uniprot
Q9BV08
resolver
uniprot_entry
MCHR1_HUMAN
resolver
uniprot_sec
B2RBX6
resolver
uniprot_sec
Q5R3J1
resolver
uniprot_sec
Q96S47
resolver
uniprot_sec
Q9BV08
resolver
amino_acid_sequence
MDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for melanin-concentrating hormone (MCH) that signals primarily through G(i/o) to inhibit adenylyl cyclase, and can additionally couple to G(q/11) to stimulate phospholipase C and mobilize intracellular calcium (PubMed:10421367, PubMed:15340116, PubMed:38710677, PubMed:39616153). Predominantly localized within the central nervous system where it regulates various physiological processes including feeding behavior, energy homeostasis, stress/anxiety-related behaviors and sleep (PubMed:10421367, PubMed:15166293, PubMed:15941924). {ECO:0000269|PubMed:10421367, ECO:0000269|PubMed:15166293, ECO:0000269|PubMed:15340116, ECO:0000269|PubMed:15941924, ECO:0000269|PubMed:38710677, ECO:0000269|PubMed:39616153}.
uniprot
proteins
mass_dalton
38940
uniprot
proteins
mutagenesis
MUTAGEN 70; /note="K->A: Loss of MCH-induced Gi and Gq activity."; /evidence="ECO:0000269|PubMed:39616153"; MUTAGEN 70; /note="K->E: Loss of MCH-induced Gi and Gq activity."; /evidence="ECO:0000269|PubMed:39616153"; MUTAGEN 71; /note="L->A: Decreased MCH-induced Gi and Gq activity."; /evidence="ECO:0000269|PubMed:39616153"; MUTAGEN 71; /note="L->E: Decreased MCH-induced Gi activity."; /evidence="ECO:0000269|PubMed:39616153"; MUTAGEN 127; /note="Q->A: Loss of MCH-induced Gi activity. Increased basal activity."; /evidence="ECO:0000269|PubMed:38710677, ECO:0000269|PubMed:39616153"; MUTAGEN 152; /note="T->R: Increased MCH-induced Gq activity."; /evidence="ECO:0000269|PubMed:38710677"; MUTAGEN 185; /note="I->A: Loss of MCH-induced Gi activity."; /evidence="ECO:0000269|PubMed:39616153"; MUTAGEN 187; /note="F->A: Decreased MCH-induced Gi activity."; /evidence="ECO:0000269|PubMed:39616153"; MUTAGEN 293; /note="Y->A: Loss of MCH-induced Gi activity."; /evidence="ECO:0000269|PubMed:39616153"; MUTAGEN 297; /note="I->A: Loss of MCH-induced Gi activity."; /evidence="ECO:0000269|PubMed:39616153"; MUTAGEN 301; /note="Y->A: Loss of MCH-induced Gi activity."; /evidence="ECO:0000269|PubMed:38710677, ECO:0000269|PubMed:39616153
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10421367
uniprot
proteins
pubmed
10441476
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15166293
uniprot
proteins
pubmed
15340116
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15941924
uniprot
proteins
pubmed
16945926
uniprot
proteins
pubmed
38710677
uniprot
proteins
pubmed
39616153
uniprot
proteins
pubmed
8977118
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10421367, ECO:0000305|PubMed:15340116}; Multi-pass membrane protein {ECO:0000269|PubMed:38710677, ECO:0000269|PubMed:39616153}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..67; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 80..102; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 117..139; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 159..181; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 210..232; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 253..275; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 290..312; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins