Psmd10
entrez
53380
canonical
uniprot
Q9Z2X2
canonical
ensembl
ENSMUSG00000031429
resolver
ensp
ENSMUSP00000033805
resolver
ensp
ENSMUSP00000108602
resolver
enst
ENSMUST00000033805
resolver
enst
ENSMUST00000112978
resolver
genesymbol
Psmd10
resolver
uniprot
A2AG83
resolver
uniprot
Q8R0G2
resolver
uniprot
Q9D383
resolver
uniprot
Q9D7N8
resolver
uniprot_entry
A2AG83_MOUSE
resolver
uniprot_entry
PSD10_MOUSE
resolver
uniprot_sec
Q8R0G2
resolver
uniprot_sec
Q9D383
resolver
uniprot_sec
Q9D7N8
resolver
amino_acid_sequence
MEGCVSNIMICNLAYSGKLDELKERILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLVKGAHVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYDATAMHRAAAKGNLKMVHILLFYKASTNIQDTEGNTPLHLACDEERVEEAKFLVTQGASIYIENKEEKTPLQVAKGGLGLILKRLAESEEASM
uniprot
proteins
function
FUNCTION: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module (By similarity). Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. {ECO:0000250, ECO:0000269|PubMed:20628200}.; FUNCTION: Acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
25084
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17292836
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20628200
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
231
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins