ATP12A
entrez
479
canonical
uniprot
P54707
canonical
ensembl
ENSG00000075673
resolver
ensp
ENSP00000218548
resolver
ensp
ENSP00000371372
resolver
genesymbol
ATP12A
resolver
genesymbol_syn
ATP1AL1
resolver
hgnc
HGNC:13816
resolver
uniprot
B4E0R9
resolver
uniprot
Q13816
resolver
uniprot
Q13817
resolver
uniprot
Q16734
resolver
uniprot
Q5W035
resolver
uniprot
Q8N5U2
resolver
uniprot_entry
AT12A_HUMAN
resolver
uniprot_entry
B4E0R9_HUMAN
resolver
uniprot_sec
Q13816
resolver
uniprot_sec
Q13817
resolver
uniprot_sec
Q16734
resolver
uniprot_sec
Q5W035
resolver
uniprot_sec
Q8N5U2
resolver
activity_regulation
ACTIVITY REGULATION: The ATPase activity is regulated by monovalent cations and pH. Up-regulated by K(+) ions in a dose-dependent way. Down-regulated by Na(+) ions (PubMed:11341842). Inhibited by Na(+)/K(+)-ATPase inhibitor ouabain and H(+)/K(+)-ATPase inhibitor SCH-28080 with an intermediate sensitivity to completely resistant Na(+)/K(+)-ATPases and highly sensitive H(+)/K(+)-ATPases (PubMed:11341842, PubMed:7485470, PubMed:8853415). {ECO:0000269|PubMed:11341842, ECO:0000269|PubMed:7485470, ECO:0000269|PubMed:8853415}.
uniprot
proteins
amino_acid_sequence
MHQKTPEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHKLSNRELEEKYGTDIIMGLSSTRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLWVGAFLCWIAYGIQYSSDKSASLNNVYLGCVLGLVVILTGIFAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVKGGDQIPADIRVLSSQGCRVDNSSLTGESEPQPRSSEFTHENPLETKNICFYSTTCLEGTVTGMVINTGDRTIIGHIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLDSIIFLIGIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSEDHSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVIGDASETALLKFSEVILGDVMEIRKRNRKVAEIPFNSTNKFQLSIHEMDDPHGKRFLMVMKGAPERILEKCSTIMINGEEHPLDKSTAKTFHTAYMELGGLGERVLGFCHLYLPADEFPETYSFDIDAMNFPTSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANSETVEDIAHRLNIAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANYQEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKNKDRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLINLRVEWEKDYVNDLKDSYGQEWTRYQREYLEWTGYTAFFVGILVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGITSQIIIGLILSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEVRKLFIRLYPGSWWDKNMYY
uniprot
proteins
ec_number
7.2.2.13
uniprot
proteins
ec_number
7.2.2.19
uniprot
proteins
function
FUNCTION: The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment (PubMed:11341842, PubMed:7485470, PubMed:8853415, PubMed:9774385). Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (By similarity). In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (PubMed:29391451). {ECO:0000250|UniProtKB:Q9Z1W8, ECO:0000269|PubMed:11341842, ECO:0000269|PubMed:29391451, ECO:0000269|PubMed:7485470, ECO:0000269|PubMed:8853415, ECO:0000269|PubMed:9774385}.
uniprot
proteins
mass_dalton
115511
uniprot
proteins
mutagenesis
MUTAGEN 329; /note="K->E: Abolishes targeting to the apical plasma membrane."; /evidence="ECO:0000269|PubMed:16914892
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIC subfamily
uniprot
proteins
pubmed
11341842
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16914892
uniprot
proteins
pubmed
1847115
uniprot
proteins
pubmed
22179016
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29391451
uniprot
proteins
pubmed
3035563
uniprot
proteins
pubmed
3036582
uniprot
proteins
pubmed
7485470
uniprot
proteins
pubmed
8045293
uniprot
proteins
pubmed
8838794
uniprot
proteins
pubmed
8853415
uniprot
proteins
pubmed
9774385
uniprot
proteins
pubmed
9872395
uniprot
proteins
sequence_length
1039
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:16914892}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 147..167; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 304..323; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 336..353; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 788..807; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 818..838; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 859..881; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 934..953; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 968..986; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1002..1022; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins