Pdgfd
entrez
71785
canonical
uniprot
Q925I7
canonical
ensembl
ENSMUSG00000032006
resolver
ensp
ENSMUSP00000056240
resolver
ensp
ENSMUSP00000128388
resolver
ensp
ENSMUSP00000149162
resolver
ensp
ENSMUSP00000194234
resolver
ensp
ENSMUSP00000194236
resolver
genesymbol
Pdgfd
resolver
genesymbol_syn
Scdgfb
resolver
uniprot
Q3URF6
resolver
uniprot
Q8K2L3
resolver
uniprot
Q9D1L8
resolver
uniprot_entry
PDGFD_MOUSE
resolver
uniprot_sec
Q3URF6
resolver
uniprot_sec
Q8K2L3
resolver
uniprot_sec
Q9D1L8
resolver
amino_acid_sequence
MQRLVLVSILLCANFSCYPDTFATPQRASIKALRNANLRRDESNHLTDLYQREENIQVTSNGHVQSPRFPNSYPRNLLLTWWLRSQEKTRIQLSFDHQFGLEEAENDICRYDFVEVEEVSESSTVVRGRWCGHKEIPPRITSRTNQIKITFKSDDYFVAKPGFKIYYSFVEDFQPEAASETNWESVTSSFSGVSYHSPSITDPTLTADALDKTVAEFDTVEDLLKHFNPVSWQDDLENLYLDTPHYRGRSYHDRKSKVDLDRLNDDVKRYSCTPRNHSVNLREELKLTNAVFFPRCLLVQRCGGNCGCGTVNWKSCTCSSGKTVKKYHEVLKFEPGHFKRRGKAKNMALVDIQLDHHERCDCICSSRPPR
uniprot
proteins
function
FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing (By similarity). Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. {ECO:0000250, ECO:0000269|PubMed:11980634, ECO:0000269|PubMed:14747375, ECO:0000269|PubMed:15271796}.
uniprot
proteins
mass_dalton
42809
uniprot
proteins
post_translational_modification
PTM: Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
PDGF/VEGF growth factor family
uniprot
proteins
pubmed
11331881
uniprot
proteins
pubmed
11331882
uniprot
proteins
pubmed
11980634
uniprot
proteins
pubmed
12890490
uniprot
proteins
pubmed
14514732
uniprot
proteins
pubmed
14747375
uniprot
proteins
pubmed
15207812
uniprot
proteins
pubmed
15271796
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Released by platelets upon wounding. {ECO:0000250}.
uniprot
proteins