LPO
entrez
4025
canonical
uniprot
P22079
canonical
ensembl
ENSG00000167419
resolver
ensp
ENSP00000262290
resolver
ensp
ENSP00000400245
resolver
ensp
ENSP00000537049
resolver
genesymbol
LPO
resolver
genesymbol_syn
SAPX
resolver
hgnc
HGNC:6678
resolver
uniprot
A5JUY4
resolver
uniprot
E7EMJ3
resolver
uniprot
Q13408
resolver
uniprot
Q3KNQ2
resolver
uniprot_entry
PERL_HUMAN
resolver
uniprot_sec
A5JUY4
resolver
uniprot_sec
E7EMJ3
resolver
uniprot_sec
Q13408
resolver
uniprot_sec
Q3KNQ2
resolver
amino_acid_sequence
MRVLLHLPALLASLILLQAAASTTRAQTTRTSAISDTVSQAKVQVNKAFLDSRTRLKTAMSSETPTSRQLSEYLKHAKGRTRTAIRNGQVWEESLKRLRQKASLTNVTDPSLDLTSLSLEVGCGAPAPVVRCDPCSPYRTITGDCNNRRKPALGAANRALARWLPAEYEDGLSLPFGWTPGKTRNGFPLPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGSSEYSKAQCDEYCIQGDNCFPIMFPPNDPKAGTQGKCMPFFRAGFVCPTPPYKSLAREQINALTSFLDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKKPSPCEFINTTARVPCFLAGDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAFVQIITFRDYLPILLGDHMQKWIPPYQGYSESVDPRISNVFTFAFRFGHLEVPSSMFRLDENYQPWGPEPELPLHTLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQPTHRIHGFDLAAINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGLYGTPDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENPGVFTNEQKDSLQKMSFSRLVCDNTRITKVPRDPFWANSYPYDFVDCSAIDKLDLSPWASVKN
uniprot
proteins
ec_number
1.11.1.7
uniprot
proteins
function
FUNCTION: Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (PubMed:6295491). Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (By similarity). Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism (PubMed:12626341). Shows antibacterial properties against Pseudomonas aeruginosa (PubMed:12626341). The lactoperoxidase-SCN(-)-H2O2 system shows antibacterial properties against Burkholderia cepacia and Haemophilus influenzae in vitro (PubMed:12626341). Present in mammary and salivary gland secretions and may contribute to airway host defense against infection (PubMed:12626341). May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation (By similarity). {ECO:0000250|UniProtKB:P80025, ECO:0000250|UniProtKB:Q5SW46, ECO:0000269|PubMed:12626341, ECO:0000269|PubMed:6295491}.
uniprot
proteins
mass_dalton
80288
uniprot
proteins
protein_family
Peroxidase family
uniprot
proteins
protein_family
XPO subfamily
uniprot
proteins
pubmed
10715594
uniprot
proteins
pubmed
12626341
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16740002
uniprot
proteins
pubmed
18780401
uniprot
proteins
pubmed
19059195
uniprot
proteins
pubmed
2222811
uniprot
proteins
pubmed
6295491
uniprot
proteins
pubmed
8964511
uniprot
proteins
sequence_length
712
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12626341}. Cytoplasm {ECO:0000250|UniProtKB:Q5SW46}.
uniprot
proteins