Plppr4
entrez
229791
canonical
uniprot
Q7TME0
canonical
ensembl
ENSMUSG00000044667
resolver
ensp
ENSMUSP00000052306
resolver
enst
ENSMUST00000061071
resolver
genesymbol
Plppr4
resolver
genesymbol_syn
D3Bwg0562e
resolver
genesymbol_syn
Kiaa0455
resolver
genesymbol_syn
Lppr4
resolver
genesymbol_syn
Php1
resolver
genesymbol_syn
Prg1
resolver
uniprot
B2RQ15
resolver
uniprot
Q6ZQA8
resolver
uniprot
Q8BV73
resolver
uniprot
Q8BXK2
resolver
uniprot
Q8R3R6
resolver
uniprot_entry
PLPR4_MOUSE
resolver
uniprot_sec
B2RQ15
resolver
uniprot_sec
Q6ZQA8
resolver
uniprot_sec
Q8BV73
resolver
uniprot_sec
Q8BXK2
resolver
uniprot_sec
Q8R3R6
resolver
amino_acid_sequence
MQRAGSSGARGECDISGAGRLRLEQAARLGGRTVHTSPGGGLGARQAAGMSAKERPKGKVIKDSVTLLPCFYFVELPILASSVVSLYFLELTDVFKPVHSGFSCYDRSLSMPYIEPTQEAIPFLMLLSLAFAGPAITIMVGEGILYCCLSKRRNGAGLEPNINAGGCNFNSFLRRAVRFVGVHVFGLCSTALITDIIQLSTGYQAPYFLTVCKPNYTSLNVSCKENSYIVEDICSGSDLTVINSGRKSFPSQHATLAAFAAVYVSMYFNSTLTDSSKLLKPLLVFTFIICGIICGLTRITQYKNHPVDVYCGFLIGGGIALYLGLYAVGNFLPSEDSMLQHRDALRSLTDLNQDPSRVLSAKNGSSGDGIAHTEGILNRNHRDASSLTNLKRANADVEIITPRSPMGKESMVTFSNTLPRANTPSVEDPVRRNASIHASMDSARSKQLLTQWKSKNESRKMSLQVMDTEPEGQSPPRSIEMRSSSEPSRVGVNGDHHVPGNQYLKIQPGTVPGCNNSMPGGPRVSIQSRPGSSQLVHIPEETQENISTSPKSSSARAKWLKAAEKTVACNRSNNQPRIMQVIAMSKQQGVLQSSPKNAEGSTVTCTGSIRYKTLTDHEPSGIVRVEAHPENNRPIIQIPSSTEGEGSGSWKWKAPEKSSLRQTYELNDLNRDSESCESLKDSFGSGDRKRSNIDSNEHHHHGITTIRVTPVEGSEIGSETLSVSSSRDSTLRRKGNIILIPERSNSPENTRNIFYKGTSPTRAYKD
uniprot
proteins
function
FUNCTION: Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways (PubMed:19766573). Binds lysophosphatidic acid (LPA) and mediates its internalization into cells (PubMed:26671989). Could act as receptor or a transporter of this lipid at the post-synaptic membrane (PubMed:19766573, PubMed:26671989). Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity). {ECO:0000250|UniProtKB:Q7TMB7, ECO:0000269|PubMed:19766573, ECO:0000269|PubMed:26671989}.
uniprot
proteins
mass_dalton
83290
uniprot
proteins
mutagenesis
MUTAGEN 253; /note="H->Q: Loss of function in regulation of glutamatergic synaptic transmission."; /evidence="ECO:0000269|PubMed:19766573"; MUTAGEN 300; /note="T->S: Loss of function in regulation of glutamatergic synaptic transmission."; /evidence="ECO:0000269|PubMed:36977636"; MUTAGEN 346; /note="R->T: No effect on localization. Decreased O-glycosylation. Loss of function in LPA internalization into cells. Loss of function in regulation of glutamatergic synaptic transmission."; /evidence="ECO:0000269|PubMed:26671989, ECO:0000269|PubMed:36977636"; MUTAGEN 347; /note="S->A,D: Loss of function in LPA import into cell."; /evidence="ECO:0000269|PubMed:26671989
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. Probably at Ser-347. {ECO:0000269|PubMed:26671989}.
uniprot
proteins
protein_family
PA-phosphatase related phosphoesterase family
uniprot
proteins
pubmed
12730698
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19766573
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26671989
uniprot
proteins
pubmed
36977636
uniprot
proteins
sequence_length
766
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic density membrane {ECO:0000269|PubMed:19766573, ECO:0000269|PubMed:26671989}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 68..88; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 248..268; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 309..329; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins