Slc27a5
entrez
26459
canonical
uniprot
Q4LDG0
canonical
ensembl
ENSMUSG00000030382
resolver
ensp
ENSMUSP00000032539
resolver
enst
ENSMUST00000032539
resolver
genesymbol
Slc27a5
resolver
genesymbol_syn
Acsb
resolver
genesymbol_syn
Acsvl6
resolver
genesymbol_syn
Fatp5
resolver
genesymbol_syn
Vlacsr
resolver
uniprot
A6H6C1
resolver
uniprot
O88694
resolver
uniprot
Q3UNC6
resolver
uniprot
Q91VD5
resolver
uniprot_entry
Q3UNC6_MOUSE
resolver
uniprot_entry
S27A5_MOUSE
resolver
uniprot_sec
A6H6C1
resolver
uniprot_sec
O88694
resolver
uniprot_sec
Q91VD5
resolver
amino_acid_sequence
MGIWKKLTLLLLLLLLVGLGQPPWPAAMALALRWFLGDPTCLVLLGLALLGRPWISSWMPHWLSLVGAALTLFLLPLQPPPGLRWLHKDVAFTFKMLFYGLKFRRRLNKHPPETFVDALERQALAWPDRVALVCTGSEGSSITNSQLDARSCQAAWVLKAKLKDAVIQNTRDAAAILVLPSKTISALSVFLGLAKLGCPVAWINPHSRGMPLLHSVRSSGASVLIVDPDLQENLEEVLPKLLAENIHCFYLGHSSPTPGVEALGASLDAAPSDPVPASLRATIKWKSPAIFIFTSGTTGLPKPAILSHERVIQVSNVLSFCGCRADDVVYDVLPLYHTIGLVLGFLGCLQVGATCVLAPKFSASRFWAECRQHGVTVILYVGEILRYLCNVPEQPEDKIHTVRLAMGNGLRANVWKNFQQRFGPIRIWEFYGSTEGNVGLMNYVGHCGAVGRTSCILRMLTPFELVQFDIETAEPLRDKQGFCIPVEPGKPGLLLTKVRKNQPFLGYRGSQAESNRKLVANVRRVGDLYFNTGDVLTLDQEGFFYFQDRLGDTFRWKGENVSTGEVECVLSSLDFLEEVNVYGVPVPGCEGKVGMAAVKLAPGKTFDGQKLYQHVRSWLPAYATPHFIRIQDSLEITNTYKLVKSRLVREGFDVGIIADPLYILDNKAQTFRSLMPDVYQAVCEGTWNL
uniprot
proteins
ec_number
6.2.1.-
uniprot
proteins
ec_number
6.2.1.3
uniprot
proteins
ec_number
6.2.1.7
uniprot
proteins
function
FUNCTION: Mediates the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes (PubMed:16618416). Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (By similarity). Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via ATP-dependent formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:16618417). Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (By similarity). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (By similarity). Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (PubMed:16618416, PubMed:16618417). {ECO:0000250|UniProtKB:Q9Y2P5, ECO:0000269|PubMed:16618416, ECO:0000269|PubMed:16618417}.
uniprot
proteins
mass_dalton
76203
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
11980911
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16618416
uniprot
proteins
pubmed
16618417
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9642112
uniprot
proteins
pubmed
9671728
uniprot
proteins
sequence_length
689
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y2P5}; Multi-pass membrane protein {ECO:0000255}. Microsome {ECO:0000250|UniProtKB:Q9ES38}. Cell membrane {ECO:0000269|PubMed:16618416}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 55..75; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins