Ccr5
entrez
12774
canonical
uniprot
P51682
canonical
ensembl
ENSMUSG00000079227
resolver
ensp
ENSMUSP00000107069
resolver
enst
ENSMUST00000111442
resolver
genesymbol
Ccr5
resolver
genesymbol_syn
Cmkbr5
resolver
uniprot
O35313
resolver
uniprot
O35891
resolver
uniprot
P97308
resolver
uniprot
P97405
resolver
uniprot
Q3ZAZ8
resolver
uniprot
Q61867
resolver
uniprot_entry
CCR5_MOUSE
resolver
uniprot_sec
O35313
resolver
uniprot_sec
O35891
resolver
uniprot_sec
P97308
resolver
uniprot_sec
P97405
resolver
uniprot_sec
Q3ZAZ8
resolver
uniprot_sec
Q61867
resolver
amino_acid_sequence
MDFQGSVPTYSYDIDYGMSAPCQKINVKQIAAQLLPPLYSLVFIFGFVGNMMVFLILISCKKLKSVTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKVRTVNFGVITSVVTWAVAVFASLPEIIFTRSQKEGFHYTCSPHFPHTQYHFWKSFQTLKMVILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLLLTTFQEFFGLNNCSSSNRLDQAMQATETLGMTHCCLNPVIYAFVGEKFRSYLSVFFRKHMVKRFCKRCSIFQQDNPDRASSVYTRSTGEHEVSTGL
uniprot
proteins
function
FUNCTION: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor. {ECO:0000250|UniProtKB:P51681}.
uniprot
proteins
mass_dalton
40785
uniprot
proteins
post_translational_modification
PTM: Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4 (By similarity). {ECO:0000250|UniProtKB:P51681}.; PTM: O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding (By similarity). {ECO:0000250|UniProtKB:P51681}.; PTM: Palmitoylation in the C-terminal is important for cell surface expression. {ECO:0000250|UniProtKB:P51681}.; PTM: Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES. {ECO:0000250|UniProtKB:P51681}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
8631787
uniprot
proteins
pubmed
8662890
uniprot
proteins
pubmed
9261347
uniprot
proteins
pubmed
9343222
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 33..60; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 105..126; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 144..168; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 201..220; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 238..262; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 280..303; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins