Ophn1
entrez
94190
canonical
uniprot
Q99J31
canonical
ensembl
ENSMUSG00000031214
resolver
ensp
ENSMUSP00000033560
resolver
ensp
ENSMUSP00000109457
resolver
enst
ENSMUST00000033560
resolver
enst
ENSMUST00000113826
resolver
genesymbol
Ophn1
resolver
uniprot
Q544K7
resolver
uniprot
Q8CA59
resolver
uniprot_entry
OPHN1_MOUSE
resolver
uniprot_entry
Q8CA59_MOUSE
resolver
uniprot_sec
Q544K7
resolver
amino_acid_sequence
MGHPPLEFSDCYLDSPDFRQRLKYYEEELERTNKFIKDVIKDGSALISAMRNYSSAVQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVQNASDLLIKPLETFRKEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLLEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWAKYYCRYEKETRMLTMIPMEQKPGAKQGPVDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQAPSEANRRLWMEAMDGKEPIYHTPITKQEEMELNEVGFKFVRKCINFIETKGIKTEGLYRTVGSNIQVQKLLYAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYKLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIKHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEDSQVPPVPPPRVTARRHKPITISKRLLREKTVFYTSSLDENKDESHHQTPNGTITSNLDPPKLLQHLKPPMQKSGETDPGRKSPSRPVSDCQSEPCLETDVGRLLFRLQDGGTKATPKASNGPVPGSGHTKTSSFHIRRPAPRPMAHHKEGDTDGFSKVRPPGEKQTIIRPPVRPPDPPCRSITPQKPEPKPETGSGNADEIPSSVVASRTRFFETASRKTGSSQGKLPGDES
uniprot
proteins
function
FUNCTION: Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals (By similarity). Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation. {ECO:0000250, ECO:0000269|PubMed:21874017}.
uniprot
proteins
mass_dalton
91985
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21874017
uniprot
proteins
sequence_length
802
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynapse {ECO:0000269|PubMed:21874017}. Presynapse {ECO:0000269|PubMed:21874017}. Cell projection, axon {ECO:0000269|PubMed:21874017}. Cell projection, dendritic spine {ECO:0000269|PubMed:21874017}. Cell projection, dendrite {ECO:0000269|PubMed:21874017}. Cytoplasm {ECO:0000269|PubMed:21874017}. Note=Present in both presynaptic and postsynaptic sites. {ECO:0000250}.
uniprot
proteins