FCER1A
entrez
2205
canonical
uniprot
P12319
canonical
ensembl
ENSG00000179639
resolver
ensembl
ENSG00000291905
resolver
ensp
ENSP00000357096
resolver
ensp
ENSP00000357097
resolver
ensp
ENSP00000509626
resolver
ensp
ENSP00000517534
resolver
ensp
ENSP00000517535
resolver
ensp
ENSP00000517536
resolver
enst
ENST00000368114
resolver
enst
ENST00000368115
resolver
enst
ENST00000693622
resolver
enst
ENST00000709171
resolver
enst
ENST00000709172
resolver
enst
ENST00000709173
resolver
genesymbol
FCER1A
resolver
genesymbol_syn
FCE1A
resolver
hgnc
HGNC:3609
resolver
uniprot
E9PRN1
resolver
uniprot_entry
E9PRN1_HUMAN
resolver
uniprot_entry
FCERA_HUMAN
resolver
amino_acid_sequence
MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN
uniprot
proteins
function
FUNCTION: High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions. {ECO:0000269|PubMed:8114916, ECO:0000269|PubMed:8551243}.
uniprot
proteins
mass_dalton
29596
uniprot
proteins
pubmed
10917520
uniprot
proteins
pubmed
11531339
uniprot
proteins
pubmed
1472946
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2964640
uniprot
proteins
pubmed
2967464
uniprot
proteins
pubmed
8114916
uniprot
proteins
pubmed
8125119
uniprot
proteins
pubmed
8551243
uniprot
proteins
pubmed
9875849
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8114916}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 206..224; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins