Fahd1
entrez
68636
canonical
uniprot
Q8R0F8
canonical
ensembl
ENSMUSG00000045316
resolver
ensp
ENSMUSP00000055827
resolver
enst
ENSMUST00000049642
resolver
genesymbol
Fahd1
resolver
uniprot
A0AAG1ESS4
resolver
uniprot
Q3U020
resolver
uniprot
Q3UQY4
resolver
uniprot
Q8BLJ7
resolver
uniprot
Q9JJB2
resolver
uniprot_entry
A0AAG1ESS4_MOUSE
resolver
uniprot_entry
FAHD1_MOUSE
resolver
uniprot_sec
Q3U020
resolver
uniprot_sec
Q3UQY4
resolver
uniprot_sec
Q8BLJ7
resolver
uniprot_sec
Q9JJB2
resolver
activity_regulation
ACTIVITY REGULATION: Oxaloacetate decarboxylation is potently and competitively inhibited by oxalate. {ECO:0000269|PubMed:25575590}.
uniprot
proteins
amino_acid_sequence
MASTKPLSRFWEWGKNIVCVGRNYADHVKEMRSTVLSEPVLFLKPSTAYAPEGSPVLMPAYCRNLHHEVELGVLLGKRGEAIPEAAAMDYVAGYALCLDMTARDVQEECKKKGLPWTLAKSFTSSCPVSAFVPKEKIPDPHALRLWLKVNGELRQEGKTSSMIFSIPYIISYVSKIITLEEGDLILTGTPKGVGPIKENDEIEAGIDGVVSMRFKVKRSEY
uniprot
proteins
ec_number
3.7.1.5
uniprot
proteins
ec_number
4.1.1.112
uniprot
proteins
ec_number
5.3.2.2
uniprot
proteins
function
FUNCTION: Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate (By similarity). It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition (By similarity). Also acts as a weak oxaloacetate decarboxylase (ODx), catalyzing the decarboxylation of oxaloacetate (OAA) to pyruvate and CO(2), and as such is likely a regulatory enzyme in the TCA cycle (Probable) (PubMed:25575590, PubMed:32068790). Also displays acylpyruvase activity, being able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro (PubMed:32068790). {ECO:0000250|UniProtKB:Q6P587, ECO:0000269|PubMed:32068790, ECO:0000305|PubMed:25575590}.
uniprot
proteins
mass_dalton
24521
uniprot
proteins
protein_family
FAH family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21878618
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
25575590
uniprot
proteins
pubmed
32068790
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q6P587}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6P587}.
uniprot
proteins