MFSD1
entrez
64747
canonical
uniprot
Q9H3U5
canonical
ensembl
ENSG00000118855
resolver
ensp
ENSP00000403117
resolver
ensp
ENSP00000498818
resolver
ensp
ENSP00000684300
resolver
enst
ENST00000651862
resolver
genesymbol
MFSD1
resolver
genesymbol_syn
SMAP4
resolver
hgnc
HGNC:25874
resolver
uniprot
A0A494C105
resolver
uniprot
B4DGJ8
resolver
uniprot
B4DMR8
resolver
uniprot
B4DU49
resolver
uniprot
B4DWU1
resolver
uniprot
C9JS94
resolver
uniprot
J3KQL7
resolver
uniprot
Q05C07
resolver
uniprot
Q5XKJ1
resolver
uniprot
Q8IVS1
resolver
uniprot
Q8IXG4
resolver
uniprot
Q9H7X1
resolver
uniprot_entry
A0A494C105_HUMAN
resolver
uniprot_entry
MFSD1_HUMAN
resolver
uniprot_sec
B4DGJ8
resolver
uniprot_sec
B4DMR8
resolver
uniprot_sec
B4DU49
resolver
uniprot_sec
B4DWU1
resolver
uniprot_sec
C9JS94
resolver
uniprot_sec
J3KQL7
resolver
uniprot_sec
Q05C07
resolver
uniprot_sec
Q5XKJ1
resolver
uniprot_sec
Q8IVS1
resolver
uniprot_sec
Q8IXG4
resolver
uniprot_sec
Q9H7X1
resolver
amino_acid_sequence
MEEEDEEARALLAGGPDEADRGAPAAPGALPALCDPSRLAHRLLVLLLMCFLGFGSYFCYDNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFFGGFLIDRVFGIRWGTIIFSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYSKIEALLGSAGHTTLGITLMIGGITCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTDVKDFSLPLWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMMLAFTMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIACVSLSLLSVVLLYLVNRAQGGNLNYSARQREEIKFSHTE
uniprot
proteins
function
FUNCTION: Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol (PubMed:38507452). Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion (PubMed:30910009). Also essential for liver homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9DC37, ECO:0000269|PubMed:30910009, ECO:0000269|PubMed:38507452}.
uniprot
proteins
mass_dalton
51209
uniprot
proteins
mutagenesis
MUTAGEN 11..12; /note="LL->AA: Loss of localization to lysosome. Localizes to plasma membrane."; /evidence="ECO:0000269|PubMed:38507452
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
30910009
uniprot
proteins
pubmed
38507452
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:38507452}; Multi-pass membrane protein {ECO:0000255}. Note=Also detected in Golgi when overexpressed. {ECO:0000269|PubMed:30910009}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 83..103; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 135..155; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..191; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 266..286; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 303..323; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 331..351; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 361..381; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 392..412; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 418..438; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins