Gabbr1
entrez
81657
canonical
uniprot
Q9Z0U4
canonical
ensembl
ENSRNOG00000000774
resolver
ensembl
ENSRNOG00055009006
resolver
ensembl
ENSRNOG00060003245
resolver
ensembl
ENSRNOG00065026733
resolver
ensp
ENSRNOP00000071413
resolver
ensp
ENSRNOP00000072226
resolver
ensp
ENSRNOP00000075181
resolver
ensp
ENSRNOP00000098098
resolver
enst
ENSRNOT00000120416
resolver
genesymbol
Gabbr1
resolver
uniprot
A0A9K3Y6U0
resolver
uniprot
A0ABK0L6X1
resolver
uniprot
O08620
resolver
uniprot
O08621
resolver
uniprot
Q9Z0F9
resolver
uniprot
Q9Z308
resolver
uniprot_entry
A0A9K3Y6U0_RAT
resolver
uniprot_entry
A0ABK0L6X1_RAT
resolver
uniprot_entry
GABR1_RAT
resolver
uniprot_sec
O08620
resolver
uniprot_sec
O08621
resolver
uniprot_sec
Q9Z0F9
resolver
uniprot_sec
Q9Z308
resolver
amino_acid_sequence
MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
uniprot
proteins
function
FUNCTION: Component of a heterodimeric G protein-coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872315, PubMed:9872317, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:10658574, PubMed:9872317). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10924501, PubMed:9872315, PubMed:9872744). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10457184, PubMed:10692480, PubMed:10924501, PubMed:9069281, PubMed:9872315, PubMed:9872744). Calcium is required for high affinity binding to GABA (PubMed:10692480). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10692480, PubMed:10924501, PubMed:9872744). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (By similarity). {ECO:0000250|UniProtKB:Q9UBS5, ECO:0000269|PubMed:10075644, ECO:0000269|PubMed:10457184, ECO:0000269|PubMed:10658574, ECO:0000269|PubMed:10692480, ECO:0000269|PubMed:10924501, ECO:0000269|PubMed:9069281, ECO:0000269|PubMed:9872315, ECO:0000269|PubMed:9872744}.
uniprot
proteins
mass_dalton
108204
uniprot
proteins
mutagenesis
MUTAGEN 247; /note="S->A: No change in the affinity for GABA."; /evidence="ECO:0000269|PubMed:10692480"; MUTAGEN 268; /note="S->A: No change in the affinity for GABA."; /evidence="ECO:0000269|PubMed:10692480"; MUTAGEN 269; /note="S->A: Decrease in the affinity for GABA."; /evidence="ECO:0000269|PubMed:10692480
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
protein_family
GABA-B receptor subfamily
uniprot
proteins
pubmed
10075644
uniprot
proteins
pubmed
10457184
uniprot
proteins
pubmed
10658574
uniprot
proteins
pubmed
10692480
uniprot
proteins
pubmed
10727622
uniprot
proteins
pubmed
10924501
uniprot
proteins
pubmed
14718537
uniprot
proteins
pubmed
15304491
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
9069281
uniprot
proteins
pubmed
9872315
uniprot
proteins
pubmed
9872317
uniprot
proteins
pubmed
9872744
uniprot
proteins
pubmed
9875211
uniprot
proteins
sequence_length
960
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10457184, ECO:0000269|PubMed:14718537, ECO:0000269|PubMed:9069281, ECO:0000269|PubMed:9872315}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000269|PubMed:10924501}; Multi-pass membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000269|PubMed:10924501, ECO:0000269|PubMed:9872317}. Perikaryon {ECO:0000269|PubMed:14718537}. Note=Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane (PubMed:10457184). Colocalizes with ATF4 in hippocampal neuron dendritic membranes (PubMed:10924501). {ECO:0000269|PubMed:10924501, ECO:0000305|PubMed:10457184}.
uniprot
proteins
transmembrane_region
TRANSMEM 591..611; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 631..651; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 667..687; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 710..730; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 768..788; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 804..824; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 833..853; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins