GZMB
entrez
3002
canonical
uniprot
P10144
canonical
ensembl
ENSG00000100453
resolver
ensp
ENSP00000216341
resolver
ensp
ENSP00000387385
resolver
enst
ENST00000216341
resolver
enst
ENST00000415355
resolver
genesymbol
GZMB
resolver
genesymbol_syn
CGL1
resolver
genesymbol_syn
CSPB
resolver
genesymbol_syn
CTLA1
resolver
genesymbol_syn
GRB
resolver
hgnc
HGNC:4709
resolver
uniprot
J3KQ52
resolver
uniprot
Q67BC3
resolver
uniprot
Q6XGZ4
resolver
uniprot
Q8N1D2
resolver
uniprot
Q9UCC1
resolver
uniprot_entry
GRAB_HUMAN
resolver
uniprot_entry
J3KQ52_HUMAN
resolver
uniprot_entry
Q67BC3_HUMAN
resolver
uniprot_entry
Q6XGZ4_HUMAN
resolver
uniprot_sec
Q8N1D2
resolver
uniprot_sec
Q9UCC1
resolver
activity_regulation
ACTIVITY REGULATION: Inactivated by the serine protease inhibitor diisopropylfluorophosphate. {ECO:0000269|PubMed:8258716}.
uniprot
proteins
amino_acid_sequence
MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWIKKTMKRY
uniprot
proteins
ec_number
3.4.21.79
uniprot
proteins
function
FUNCTION: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:1985927, PubMed:3262682, PubMed:3263427). It cleaves after Asp (PubMed:1985927, PubMed:8258716). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (PubMed:31953257, PubMed:32188940). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis (PubMed:9852092). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (By similarity). {ECO:0000250|UniProtKB:P04187, ECO:0000269|PubMed:1985927, ECO:0000269|PubMed:31953257, ECO:0000269|PubMed:32188940, ECO:0000269|PubMed:3262682, ECO:0000269|PubMed:3263427, ECO:0000269|PubMed:8258716, ECO:0000269|PubMed:9852092}.
uniprot
proteins
mass_dalton
27716
uniprot
proteins
protein_family
Granzyme subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
11209755
uniprot
proteins
pubmed
11325591
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12721789
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1985927
uniprot
proteins
pubmed
20038786
uniprot
proteins
pubmed
2323780
uniprot
proteins
pubmed
2332171
uniprot
proteins
pubmed
2365998
uniprot
proteins
pubmed
24088571
uniprot
proteins
pubmed
2788607
uniprot
proteins
pubmed
2953813
uniprot
proteins
pubmed
31953257
uniprot
proteins
pubmed
32188940
uniprot
proteins
pubmed
3258865
uniprot
proteins
pubmed
3261871
uniprot
proteins
pubmed
3262682
uniprot
proteins
pubmed
3263427
uniprot
proteins
pubmed
8258716
uniprot
proteins
pubmed
9852092
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:8258716}. Cytolytic granule {ECO:0000269|PubMed:1985927, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:8258716}. Note=Delivered into the target cell by perforin (PubMed:20038786). {ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:8258716}.
uniprot
proteins