Sesn1
entrez
140742
canonical
uniprot
P58006
canonical
ensembl
ENSMUSG00000038332
resolver
ensp
ENSMUSP00000043034
resolver
ensp
ENSMUSP00000097515
resolver
enst
ENSMUST00000041438
resolver
enst
ENSMUST00000099931
resolver
genesymbol
Sesn1
resolver
genesymbol_syn
Pa26
resolver
genesymbol_syn
Sest1
resolver
uniprot
E9PXR3
resolver
uniprot
E9QPK0
resolver
uniprot
Q497S6
resolver
uniprot
Q7TNF3
resolver
uniprot_entry
E9PXR3_MOUSE
resolver
uniprot_entry
Q497S6_MOUSE
resolver
uniprot_entry
SESN1_MOUSE
resolver
uniprot_sec
E9QPK0
resolver
uniprot_sec
Q7TNF3
resolver
amino_acid_sequence
MRLAAASNEAYAASLAVSELLSCHQCGGDRGQDEELGIRIPRPLGHGPSRFIPEKEMLQVGSEDAQMHALFADSFAALGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYIGIMAAARHQCSYLVNLHVSDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSWSLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEMQVNSAGNASVSDSFFEVEALMEKMRQLQECREEEEASQEEMASRFEMEKRESMFVFSSDDDEVTPARDVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
function
FUNCTION: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25259925). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed (By similarity). {ECO:0000250|UniProtKB:P58004, ECO:0000269|PubMed:25259925}.
uniprot
proteins
mass_dalton
56637
uniprot
proteins
protein_family
Sestrin family
uniprot
proteins
pubmed
12607115
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25259925
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y6P5}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y6P5}.
uniprot
proteins