Ccin
entrez
442829
canonical
uniprot
Q8CDE2
canonical
ensembl
ENSMUSG00000070999
resolver
ensp
ENSMUSP00000092725
resolver
enst
ENSMUST00000095107
resolver
genesymbol
Ccin
resolver
uniprot
B2RX51
resolver
uniprot_entry
B2RX51_MOUSE
resolver
uniprot_entry
CALI_MOUSE
resolver
amino_acid_sequence
MKLEFTEKNYNSFVLQNLNKQRKRKEYWDMALTVDHHVFFAHRNVLAAVSPLVKSLISSNDMKTTDELYITIDPNYLSPATVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRIHCNDFLIKSIRRVNCLRYLFLAELFELKEVSDLAYSGIRDNFHFWASPEGSMHFMRCPPVIFGRLLRDENLHVLNEDQALSALISWVYFRKEEREKYFKKFFNYINLNAVSNKTLMFASNKLVGLENNSAHATLIESVLMDRKQERPCSLLSYQRKGALLDSVVILGGQKAHGKFNDGVFAYIIQENLWLKLSEMPYRAAALSATAAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEAWCLAGKMSIPMDGTAVITKGDRNLYIVTGRCLVKGYISRVGVVDCFDTCTGEVVQCITFPIEFNHRPLLSFHQDNILRVHSHRQSVEINLQKIKANKSTTSVPLLPNSCPLDVSHAICSIGDSKVFVCGGVTTASDVQTKDYTINPNAYLLDQKIGEWQTLACPPEALDCPACCLAKLPCKILQRI
uniprot
proteins
function
FUNCTION: Required for both nuclear and acrosomal shaping during spermiogenesis. {ECO:0000269|PubMed:36546111}.
uniprot
proteins
mass_dalton
66750
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="H->L: Knockin homozygous animals develop normally, however males are infertile and their spermatozoa show a substantial decrease in motility; spermatozoa from homozygous males exhibit several abnormalities, including abnormal head shaping, with an increase in their length and width, apical defect of the acrosome, and nuclear lacunae devoid of chromatin, at the flagellum, mutant spermatozoa display mitochondrial sheath misassembly and coiling tail around the nucleus; may severely impair protein stability."; /evidence="ECO:0000269|PubMed:36546111"; MUTAGEN 432; /note="R->W: Knockin homozygous animals develop normally, however males are infertile and their spermatozoa show a substantial decrease in motility; spermatozoa from homozygous males exhibit several abnormalities, including abnormal head shaping, with an increase in their length and width, apical defect of the acrosome, and nuclear lacunae devoid of chromatin, at the flagellum, mutant spermatozoa display mitochondrial sheath misassembly and coiling tail around the nucleus; when associated in trans with 447-C--I-588; may severely impair protein stability."; /evidence="ECO:0000269|PubMed:36546111"; MUTAGEN 447..588; /note="Missing: Knockin homozygous animals develop normally, however males are infertile and their spermatozoa show a substantial decrease in motility; spermatozoa from homozygous males exhibit several abnormalities, including abnormal head shaping, with an increase in their length and width, apical defect of the acrosome, and nuclear lacunae devoid of chromatin, at the flagellum, mutant spermatozoa display mitochondrial sheath misassembly and coiling tail around the nucleus; when associated in trans with W-432; may severely impair protein stability."; /evidence="ECO:0000269|PubMed:36546111
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36546111
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca, calyx {ECO:0000250|UniProtKB:Q13939}.
uniprot
proteins