Eif4g1
entrez
208643
canonical
uniprot
Q6NZJ6
canonical
ensembl
ENSMUSG00000045983
resolver
ensp
ENSMUSP00000047678
resolver
ensp
ENSMUSP00000073506
resolver
ensp
ENSMUSP00000111117
resolver
ensp
ENSMUSP00000111121
resolver
ensp
ENSMUSP00000111123
resolver
ensp
ENSMUSP00000144320
resolver
ensp
ENSMUSP00000241775
resolver
ensp
ENSMUSP00000241776
resolver
ensp
ENSMUSP00000241781
resolver
ensp
ENSMUSP00000241782
resolver
ensp
ENSMUSP00000327148
resolver
ensp
ENSMUSP00000327151
resolver
ensp
ENSMUSP00000327155
resolver
enst
ENSMUST00000073840
resolver
enst
ENSMUST00000115457
resolver
enst
ENSMUST00000115461
resolver
genesymbol
Eif4g1
resolver
uniprot
E9PVC5
resolver
uniprot
E9PVC6
resolver
uniprot
E9Q9E1
resolver
uniprot
Q6NZN8
resolver
uniprot
Q8BW99
resolver
uniprot_entry
E9PVC5_MOUSE
resolver
uniprot_entry
E9PVC6_MOUSE
resolver
uniprot_entry
E9Q9E1_MOUSE
resolver
uniprot_entry
IF4G1_MOUSE
resolver
uniprot_sec
Q6NZN8
resolver
uniprot_sec
Q8BW99
resolver
amino_acid_sequence
MNKAPQPTGPPPARSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQGGFRSLQHFYPSRAQPPSSAASRVQSAAPARPGPAPHVYPAGSQVMMIPSQISYSASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPASVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGSLEPQPNGESPQVAVIIRPDDRSQGAAIGGRPGLPGPEHSPGTESQPSSPSPTPSPPPILEPGSESNLGVLSIPGDTMTTGMIPMSVEESTPISCETGEPYCLSPEPTLAEPILEVEVTLSKPIPESEFSSSPLQVSTALVPHKVETHEPNGVIPSEDLEPEVESSTEPAPPPLSPCASESLVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKKVSSAALASILSPAPPVAPSDTSPAQEEEMEEDDDDEEGGEAESEKGGEDVPLDSTPVPAQLSQNLEVAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEVDPAVPEVENQPPTGSNPSPESEGSMVPTQPEETEETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHITDVVLDKANKTPLRQLDPSRLPGINCGPDFTPSFANLGRPALSNRGPPRGGPGGELPRGPAGLGPRRSQQGPRKETRKIISSVIMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRQSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDTASEATRPATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREFLAEGQDVGSFVAEKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWLREAEDEESDHN
uniprot
proteins
function
FUNCTION: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon. Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation. {ECO:0000250|UniProtKB:Q04637}.
uniprot
proteins
mass_dalton
176077
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1187 by PRKCA induces binding to MKNK1. {ECO:0000250|UniProtKB:Q04637}.
uniprot
proteins
protein_family
Eukaryotic initiation factor 4G family
uniprot
proteins
pubmed
15153109
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24928504
uniprot
proteins
pubmed
31403400
uniprot
proteins
sequence_length
1600
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q04637}. Nucleus {ECO:0000250|UniProtKB:Q04637}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q04637}.
uniprot
proteins