Trpm8
entrez
171384
canonical
uniprot
Q8R455
canonical
ensembl
ENSRNOG00000019035
resolver
ensembl
ENSRNOG00055010822
resolver
ensembl
ENSRNOG00060010558
resolver
ensembl
ENSRNOG00065021562
resolver
ensp
ENSRNOP00000025879
resolver
ensp
ENSRNOP00055014718
resolver
ensp
ENSRNOP00060013870
resolver
ensp
ENSRNOP00065029493
resolver
enst
ENSRNOT00000025879
resolver
enst
ENSRNOT00055018309
resolver
enst
ENSRNOT00060017862
resolver
enst
ENSRNOT00065036644
resolver
genesymbol
Trpm8
resolver
genesymbol_syn
Cmr1
resolver
uniprot_entry
TRPM8_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cold temperatures and by both natural and synthetic cooling compounds such as menthol and icilin (By similarity). Activation of the channel requires the presence of PI(4,5)P2; PI(4,5)P2 is necessary to gate the channel. Activated by intracellular Ca(2+) (By similarity). {ECO:0000250|UniProtKB:Q7Z2W7, ECO:0000250|UniProtKB:Q8R4D5}.
uniprot
proteins
amino_acid_sequence
MSFEGARLSMRSRRNGTLGSTRTLYSSVSRSTDVSYSESDLVNFIQANFKKRECVFFTRDSKAMESICKCGYAQSQHIEGTQINQNEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYLRLSCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLIRNCDDEGHFSAQYIMDDFMRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKAINTSVKSKIPCVVVEGSGQIADVIASLVEVEDVLTSSMVKEKLVRFLPRTVSRLPEEEIESWIKWLKEILESPHLLTVIKMEEAGDEVVSSAISYALYKAFSTNEQDKDNWNGQLKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRSFWKEDRSSREDLDVELHDASLTTRHPLQALFIWAILQNKKELSKVIWEQTKGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGLVSFRKKPIDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPELILYALVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDSTTYDFSHCTFSGNESKPLCVELDEYNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAYFYMVVKKCFKCCCKEKNTESSACCFRNEDNETLAWEGVMKENYLVKINTKANDNAEEMRHRFRQLDTKLNDLKGLLKEIANKIK
uniprot
proteins
function
FUNCTION: Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+) (PubMed:11882888). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin, therefore plays a central role in the detection of environmental cold temperatures (By similarity). TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel (By similarity). In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality (By similarity). {ECO:0000250|UniProtKB:Q7Z2W7, ECO:0000250|UniProtKB:Q8R4D5, ECO:0000269|PubMed:11882888}.
uniprot
proteins
mass_dalton
127629
uniprot
proteins
protein_family
LTrpC subfamily
uniprot
proteins
protein_family
TRPM8 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
11882888
uniprot
proteins
pubmed
12634279
uniprot
proteins
pubmed
19176480
uniprot
proteins
pubmed
20214891
uniprot
proteins
sequence_length
1104
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8R4D5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7Z2W7}. Membrane raft {ECO:0000269|PubMed:19176480}. Note=Lipid raft association of TRPM8 modulates channel activity. {ECO:0000269|PubMed:19176480}.
uniprot
proteins
transmembrane_region
TRANSMEM 734..758; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q8R4D5"; TRANSMEM 766..789; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q8R4D5"; TRANSMEM 797..817; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q8R4D5"; TRANSMEM 823..848; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q8R4D5"; TRANSMEM 854..890; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q8R4D5"; TRANSMEM 954..984; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q8R4D5
uniprot
proteins