RBL1
entrez
5933
canonical
uniprot
P28749
canonical
ensembl
ENSG00000080839
resolver
ensp
ENSP00000343646
resolver
ensp
ENSP00000362768
resolver
ensp
ENSP00000597910
resolver
ensp
ENSP00000661909
resolver
genesymbol
RBL1
resolver
hgnc
HGNC:9893
resolver
uniprot
A8K2W5
resolver
uniprot
Q4VXA0
resolver
uniprot
Q8N5K6
resolver
uniprot
Q9H1L5
resolver
uniprot
Q9H1M1
resolver
uniprot_entry
RBL1_HUMAN
resolver
uniprot_sec
A8K2W5
resolver
uniprot_sec
Q4VXA0
resolver
uniprot_sec
Q8N5K6
resolver
uniprot_sec
Q9H1L5
resolver
uniprot_sec
Q9H1M1
resolver
amino_acid_sequence
MFEDKPHAEGAAVVAAAGEALQALCQELNLDEGSAAEALDDFTAIRGNYSLEGEVTHWLACSLYVACRKSIIPTVGKGIMEGNCVSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKYEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRQDLLNPSFKGLPSDFHTADFTASEEPPCIIAVLCELHDGLLVEAKGIKEHYFKPYISKLFDRKILKGECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFTRDTPLGKLTAQANVEYNLQQHFEKKRSFAPSTPLTGRRYLREKEAVITPVASATQSVSRLQSIVAGLKNAPSDQLINIFESCVRNPVENIMKILKGIGETFCQHYTQSTDEQPGSHIDFAVNRLKLAEILYYKILETVMVQETRRLHGMDMSVLLEQDIFHRSLMACCLEIVLFAYSSPRTFPWIIEVLNLQPFYFYKVIEVVIRSEEGLSRDMVKHLNSIEEQILESLAWSHDSALWEALQVSANKVPTCEEVIFPNNFETGNGGNVQGHLPLMPMSPLMHPRVKEVRTDSGSLRRDMQPLSPISVHERYSSPTAGSAKRRLFGEDPPKEMLMDKIITEGTKLKIAPSSSITAENVSILPGQTLLTMATAPVTGTTGHKVTIPLHGVANDAGEITLIPLSMNTNQESKVKSPVSLTAHSLIGASPKQTNLTKAQEVHSTGINRPKRTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKTPDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDAPPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYKFNGSPSKSLKDINNMIRQGEQRTKKRVIAIDSDAESPAKRVCQENDDVLLKRLQDVVSERANH
uniprot
proteins
function
FUNCTION: Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}.
uniprot
proteins
mass_dalton
120847
uniprot
proteins
mutagenesis
MUTAGEN 640; /note="S->A: Strongly reduces phosphorylation by CDK2 and CDK4."; /evidence="ECO:0000269|PubMed:11884610"; MUTAGEN 643; /note="S->R: No effect on S-640 phosphorylation, but strongly increases S-640 phosphorylation; when associated with 657-A--A-660."; /evidence="ECO:0000269|PubMed:11884610"; MUTAGEN 650; /note="S->A: No effect on phosphorylation by CDK2."; /evidence="ECO:0000269|PubMed:11884610"; MUTAGEN 657..660; /note="KRRL->AAAA: Reduces S-640 phosphorylation by CDK2 and CDK4."; /evidence="ECO:0000269|PubMed:11884610
uniprot
proteins
post_translational_modification
PTM: Cell-cycle arrest properties are inactivated by phosphorylation on Thr-332, Ser-640, Ser-964 and Ser-975 by CDK4. {ECO:0000269|PubMed:11884610, ECO:0000269|PubMed:12006580}.
uniprot
proteins
protein_family
Retinoblastoma protein (RB) family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
11884610
uniprot
proteins
pubmed
12006580
uniprot
proteins
pubmed
12450794
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16360038
uniprot
proteins
pubmed
17671431
uniprot
proteins
pubmed
1833063
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20485545
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2546678
uniprot
proteins
pubmed
7791762
uniprot
proteins
pubmed
7935440
uniprot
proteins
pubmed
8319904
uniprot
proteins
sequence_length
1068
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins