Clstn1
entrez
65945
canonical
uniprot
Q9EPL2
canonical
ensembl
ENSMUSG00000039953
resolver
ensp
ENSMUSP00000036962
resolver
ensp
ENSMUSP00000101316
resolver
ensp
ENSMUSP00000314296
resolver
ensp
ENSMUSP00000314297
resolver
ensp
ENSMUSP00000314313
resolver
genesymbol
Clstn1
resolver
genesymbol_syn
Cs1
resolver
genesymbol_syn
Cstn1
resolver
genesymbol_syn
Kiaa0911
resolver
uniprot
A2A800
resolver
uniprot
B2KFP1
resolver
uniprot
B2KFP2
resolver
uniprot
Q69ZV9
resolver
uniprot
Q7TS67
resolver
uniprot
Q8K103
resolver
uniprot_entry
CSTN1_MOUSE
resolver
uniprot_sec
A2A800
resolver
uniprot_sec
B2KFP1
resolver
uniprot_sec
B2KFP2
resolver
uniprot_sec
Q69ZV9
resolver
uniprot_sec
Q7TS67
resolver
uniprot_sec
Q8K103
resolver
amino_acid_sequence
MLRRPAPALAPAVRLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDSPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGIIRSKEKLDCELQKDYTFTIQAYDCGKGPDGTGVKKSHKATVHIQVNDVNEYAPVFKEKSYKAAVVEGKQHSSILRVEAVDADCSPQFSQICSYEILTPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISVKPTCSPGWQGWSSRIEYEPGTGALAVFPSIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTSELLPSPSSSFNWTVGLPTDNGHDSDQVFEFNGTQAVRIPDGVVTLDPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLVFLLRQDPSEEKKYRPAEFHWKLNQVCDEDWHHFVLNVEVPSVTLYVDGIPHEPFSVTEDYPLHPTKIETQLVVGACWQEYSGVESGNETEPATMASAGGDLHMTQFFRGNLAGLTVRSGKLADKKVIDCLYTCKEGLDLQVPEDANRGVQIQASSSQAVLTLEGDNVGELDKAMQHISYLNSRQFPTPGIRRLKITSTVKCFNEAACIEVPPVEGYVMVLQPEEPKISLSGVHHFARAASEFESAEGISLFPELRIISTITREVEPEADGSEDPTVQESLVSEEIVHDLDTCEVTVEGDELNAEQESLEVDVTRLQQKGIEASHSDLGVVFTGVETMASYEEVLHLLRYRNWHTRSLLDRKFKLICSELNGRYLSNEFKVEVNVIHTANPVEHANHMAAQPQFVHPEHRSFVDLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHQRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEEDITSAESESSEEEEGGPGDGQNATRQLEWDDSTLSY
uniprot
proteins
function
FUNCTION: Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (PubMed:11161476, PubMed:24613359). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles (PubMed:17332754). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (PubMed:11161476, PubMed:12972431). {ECO:0000250|UniProtKB:Q99JH7, ECO:0000269|PubMed:11161476, ECO:0000269|PubMed:12972431, ECO:0000269|PubMed:17332754, ECO:0000269|PubMed:24613359}.; FUNCTION: [Soluble Alc-alpha]: As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. {ECO:0000269|PubMed:11161476, ECO:0000269|PubMed:12972431}.; FUNCTION: [CTF1-alpha]: In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. {ECO:0000269|PubMed:11161476, ECO:0000269|PubMed:12972431}.
uniprot
proteins
mass_dalton
108900
uniprot
proteins
mutagenesis
MUTAGEN 900; /note="E->A: Marked reduction in KLC1-binding."; /evidence="ECO:0000269|PubMed:16760430"; MUTAGEN 901; /note="M->A: Almost completely abolishes KLC1-binding."; /evidence="ECO:0000269|PubMed:16760430"; MUTAGEN 902; /note="D->A: Marked reduction in KLC1-binding."; /evidence="ECO:0000269|PubMed:16760430"; MUTAGEN 903; /note="W->A: Marked reduction in KLC1-binding; when associated with A-972. Marked alteration in anterograde axonal transport."; /evidence="ECO:0000269|PubMed:16760430"; MUTAGEN 904; /note="D->A: Almost completely abolishes KLC1-binding."; /evidence="ECO:0000269|PubMed:16760430"; MUTAGEN 905; /note="D->A: Almost completely abolishes KLC1-binding."; /evidence="ECO:0000269|PubMed:16760430"; MUTAGEN 972; /note="W->A: Marked reduction in KLC1-binding; when associated with A-903. Marked alteration in anterograde axonal transport."; /evidence="ECO:0000269|PubMed:16760430
uniprot
proteins
post_translational_modification
PTM: Proteolytically processed under normal cellular conditions (PubMed:11161476, PubMed:15037614). A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1) (PubMed:11161476, PubMed:15037614). A secondary cleavage catalyzed by presenilin gamma-secretase within the transmembrane domain releases the beta-Alc-alpha chain in the extracellular milieu and produces an intracellular fragment (AlcICD) (PubMed:11161476, PubMed:15037614). Beta-Alc-alpha secretion is largely dependent upon PSEN1 and PSEN2 (PubMed:11161476, PubMed:15037614). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1 (PubMed:11161476, PubMed:15037614). {ECO:0000269|PubMed:11161476, ECO:0000269|PubMed:15037614}.
uniprot
proteins
protein_family
Calsyntenin family
uniprot
proteins
pubmed
11161476
uniprot
proteins
pubmed
12498782
uniprot
proteins
pubmed
12972431
uniprot
proteins
pubmed
15037614
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16760430
uniprot
proteins
pubmed
17332754
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24613359
uniprot
proteins
pubmed
35279170
uniprot
proteins
sequence_length
979
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:24613359}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12972431}; Single-pass type I membrane protein. Golgi apparatus membrane {ECO:0000250|UniProtKB:O94985}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, neuron projection {ECO:0000269|PubMed:12972431, ECO:0000269|PubMed:17332754}. Vesicle {ECO:0000269|PubMed:17332754}. Note=Localized in the postsynaptic membrane of both excitatory and inhibitory synapses. {ECO:0000269|PubMed:24613359}.; SUBCELLULAR LOCATION: [Soluble Alc-alpha]: Nucleus {ECO:0000250|UniProtKB:O94985}. Note=The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. {ECO:0000250|UniProtKB:O94985}.
uniprot
proteins
transmembrane_region
TRANSMEM 860..880; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins