Mettl8
entrez
228019
canonical
uniprot
A2AUU0
canonical
ensembl
ENSMUSG00000041975
resolver
ensp
ENSMUSP00000107804
resolver
ensp
ENSMUSP00000299511
resolver
ensp
ENSMUSP00000299528
resolver
ensp
ENSMUSP00000299532
resolver
genesymbol
Mettl8
resolver
genesymbol_syn
Tip
resolver
uniprot
A2AUU3
resolver
uniprot
Q2XV35
resolver
uniprot
Q2XV36
resolver
uniprot
Q4FCR9
resolver
uniprot
Q4FCS0
resolver
uniprot
Q6PEN9
resolver
uniprot
Q99KI7
resolver
uniprot_entry
METL8_MOUSE
resolver
uniprot_sec
A2AUU3
resolver
uniprot_sec
Q2XV35
resolver
uniprot_sec
Q2XV36
resolver
uniprot_sec
Q4FCR9
resolver
uniprot_sec
Q4FCS0
resolver
uniprot_sec
Q6PEN9
resolver
uniprot_sec
Q99KI7
resolver
amino_acid_sequence
MNVIWRSCICRLRQGKVPHRCQSGVHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEDAARKKVEENSATRVAPEEQVKFESDANKYWDIFYQTHKNKFFKNRNWLLREFPEILPVNQNTKEKVGESSWDQVGSSISRTQGTETHCQESFVSPEPGSRGRSAPDPDLEEYSKGPGKTEPFPGSNATFRILEVGCGAGNSVFPILNTLQNIPGSFLYCCDFASEAVELVKSHESYSEAQCSAFIHDVCDDGLAYPFPDGILDVVLLVFVLSSIHPDRALFI
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr) (By similarity). N(3)-methylcytidine methylation modification regulates mitochondrial translation efficiency and is required for activity of the respiratory chain (By similarity). N(3)-methylcytidine methylation of mitochondrial tRNA(Ser)(UCN) requires the formation of N(6)-dimethylallyladenosine(37) (i6A37) by TRIT1 as prerequisite (By similarity). May also mediate N(3)-methylcytidine modification of mRNAs (PubMed:28655767). The existence of N(3)-methylcytidine modification on mRNAs is however unclear, and additional evidence is required to confirm the role of the N(3)-methylcytidine-specific mRNA methyltransferase activity of METTL8 in vivo (By similarity). {ECO:0000250|UniProtKB:Q9H825, ECO:0000269|PubMed:28655767}.; FUNCTION: [Isoform 5]: Overexpression in lung progenitor cells stimulates smooth muscle-specific gene expression and suppresses adipogenic gene expression. {ECO:0000269|PubMed:15992539}.; FUNCTION: [Isoform 4]: Stimulates adipogenesis. {ECO:0000269|PubMed:18710950}.; FUNCTION: [Isoform 7]: Stimulates adipogenesis. {ECO:0000269|PubMed:18710950}.
uniprot
proteins
mass_dalton
31670
uniprot
proteins
protein_family
METL family
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15992539
uniprot
proteins
pubmed
18710950
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
28655767
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9H825}. Cytoplasm {ECO:0000305|PubMed:15992539}. Nucleus {ECO:0000305|PubMed:15992539}. Note=Mitochondrial protein (By similarity). The cytoplasmic or nuclear localization observed by some groups is either the result of an incorrect localization caused by N-terminal tagging that interferes with mitochondrial targeting, or splice isoforms that lack the N-terminal mitochondrial transit sequence (By similarity). {ECO:0000250|UniProtKB:Q9H825}.; SUBCELLULAR LOCATION: [Isoform 5]: Nucleus {ECO:0000269|PubMed:15992539}. Note=Isoform 5 localizes to the nucleus upon cell stretch in embryonic lung progenitor cells. {ECO:0000269|PubMed:15992539}.
uniprot
proteins