SF1
entrez
7536
canonical
uniprot
Q15637
canonical
ensembl
ENSG00000168066
resolver
ensp
ENSP00000227503
resolver
ensp
ENSP00000334414
resolver
ensp
ENSP00000366604
resolver
ensp
ENSP00000366607
resolver
ensp
ENSP00000366611
resolver
ensp
ENSP00000396793
resolver
ensp
ENSP00000419062
resolver
ensp
ENSP00000505779
resolver
ensp
ENSP00000516498
resolver
ensp
ENSP00000674323
resolver
enst
ENST00000486867
resolver
enst
ENST00000681407
resolver
enst
ENST00000706684
resolver
genesymbol
SF1
resolver
genesymbol_syn
ZFM1
resolver
genesymbol_syn
ZNF162
resolver
hgnc
HGNC:12950
resolver
uniprot
A0A7P0T9U7
resolver
uniprot
A0A9L9PXE4
resolver
uniprot
B4DX42
resolver
uniprot
B7Z1Q1
resolver
uniprot
C9JJE2
resolver
uniprot
E7ESU3
resolver
uniprot
H7C561
resolver
uniprot
Q14818
resolver
uniprot
Q14819
resolver
uniprot
Q15913
resolver
uniprot
Q8IY00
resolver
uniprot
Q92744
resolver
uniprot
Q92745
resolver
uniprot
Q969H7
resolver
uniprot
Q9BW01
resolver
uniprot
Q9UEI0
resolver
uniprot_entry
A0A7P0T9U7_HUMAN
resolver
uniprot_entry
A0A9L9PXE4_HUMAN
resolver
uniprot_entry
B4DX42_HUMAN
resolver
uniprot_entry
H7C561_HUMAN
resolver
uniprot_entry
SF01_HUMAN
resolver
uniprot_sec
B7Z1Q1
resolver
uniprot_sec
C9JJE2
resolver
uniprot_sec
E7ESU3
resolver
uniprot_sec
Q14818
resolver
uniprot_sec
Q14819
resolver
uniprot_sec
Q15913
resolver
uniprot_sec
Q8IY00
resolver
uniprot_sec
Q92744
resolver
uniprot_sec
Q92745
resolver
uniprot_sec
Q969H7
resolver
uniprot_sec
Q9BW01
resolver
uniprot_sec
Q9UEI0
resolver
amino_acid_sequence
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGSAGMMYAPPPPPPPPMDPSNFVTMMGMGVAGMPPFGMPPAPPPPPPQN
uniprot
proteins
function
FUNCTION: Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. {ECO:0000269|PubMed:10449420, ECO:0000269|PubMed:8752089, ECO:0000269|PubMed:9660765}.
uniprot
proteins
mass_dalton
68330
uniprot
proteins
mutagenesis
MUTAGEN 15..17; /note="KKR->EED: Abolishes interaction with U2AF2."; MUTAGEN 16..18; /note="KRK->EDE: Abolishes interaction with U2AF2."; /evidence="ECO:0000269|PubMed:12718882"; MUTAGEN 20; /note="S->A: Strongly decreases interaction with U2AF2 and spliceosome assembly."; /evidence="ECO:0000269|PubMed:10449420"; MUTAGEN 20; /note="S->T: Decreases interaction with U2AF2."; /evidence="ECO:0000269|PubMed:10449420"; MUTAGEN 21; /note="R->A: Decreases interaction with U2AF2 and spliceosome assembly."; /evidence="ECO:0000269|PubMed:12718882"; MUTAGEN 21; /note="R->K: No effect."; /evidence="ECO:0000269|PubMed:12718882"; MUTAGEN 22; /note="W->A: Abolishes interaction with U2AF2."; /evidence="ECO:0000269|PubMed:12718882"; MUTAGEN 22; /note="W->F: No effect."; /evidence="ECO:0000269|PubMed:12718882"; MUTAGEN 151; /note="N->A: Decreases RNA-binding."; /evidence="ECO:0000269|PubMed:11691992"; MUTAGEN 160; /note="R->A: Strongly reduces RNA-binding."; /evidence="ECO:0000269|PubMed:11691992"; MUTAGEN 184; /note="K->A: Abolishes RNA-binding."; /evidence="ECO:0000269|PubMed:11691992"; MUTAGEN 244; /note="L->A: Decreases RNA-binding."; /evidence="ECO:0000269|PubMed:11691992"; MUTAGEN 247; /note="L->A: Decreases RNA-binding."; /evidence="ECO:0000269|PubMed:11691992"; MUTAGEN 254; /note="L->A: Slightly decreases RNA-binding."; /evidence="ECO:0000269|PubMed:11691992"; MUTAGEN 255; /note="R->A: Slightly decreases RNA-binding."; /evidence="ECO:0000269|PubMed:11691992
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly. Isoform 6 is phosphorylated on Ser-463. {ECO:0000269|PubMed:10449420}.
uniprot
proteins
protein_family
BBP/SF1 family
uniprot
proteins
pubmed
10449420
uniprot
proteins
pubmed
11691992
uniprot
proteins
pubmed
12176931
uniprot
proteins
pubmed
12718882
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17589525
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7912130
uniprot
proteins
pubmed
8752089
uniprot
proteins
pubmed
9192847
uniprot
proteins
pubmed
9573336
uniprot
proteins
pubmed
9660765
uniprot
proteins
sequence_length
639
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins