RYBP
entrez
23429
canonical
uniprot
Q8N488
canonical
ensembl
ENSG00000163602
resolver
ensembl
ENSG00000281766
resolver
ensp
ENSP00000419494
resolver
ensp
ENSP00000486012
resolver
ensp
ENSP00000493835
resolver
enst
ENST00000477973
resolver
enst
ENST00000628983
resolver
enst
ENST00000643872
resolver
genesymbol
RYBP
resolver
genesymbol_syn
DEDAF
resolver
genesymbol_syn
YEAF1
resolver
hgnc
HGNC:10480
resolver
uniprot
Q9P2W5
resolver
uniprot
Q9UMW4
resolver
uniprot_entry
RYBP_HUMAN
resolver
uniprot_sec
Q9P2W5
resolver
uniprot_sec
Q9UMW4
resolver
amino_acid_sequence
MTMGDKKSPTRPKRQAKPAADEGFWDCSVCTFRNSAEAFKCSICDVRKGTSTRKPRINSQLVAQQVAQQYATPPPPKKEKKEKVEKQDKEKPEKDKEISPSVTKKNTNKKTKPKSDILKDPPSEANSIQSANATTKTSETNHTSRPRLKNVDRSTAQQLAVTVGNVTVIITDFKEKTRSSSTSSSTVTSSAGSEQQNQSSSGSESTDKGSSRSSTPKGDMSAVNDESF
uniprot
proteins
function
FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). {ECO:0000250|UniProtKB:Q8CCI5, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:27060496, ECO:0000269|PubMed:27748911}.
uniprot
proteins
mass_dalton
24822
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated. {ECO:0000250}.
uniprot
proteins
pubmed
11395500
uniprot
proteins
pubmed
11953439
uniprot
proteins
pubmed
14765135
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16943429
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19098711
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20696397
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25519132
uniprot
proteins
pubmed
26687479
uniprot
proteins
pubmed
27060496
uniprot
proteins
pubmed
27748911
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11395500, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:27060496}. Cytoplasm {ECO:0000269|PubMed:11395500, ECO:0000269|PubMed:14765135}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q8CCI5}. Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity). {ECO:0000250|UniProtKB:Q8CCI5}.
uniprot
proteins