Anxa2
entrez
56611
canonical
uniprot
Q07936
canonical
ensembl
ENSRNOG00000010362
resolver
ensembl
ENSRNOG00055006716
resolver
ensembl
ENSRNOG00060015561
resolver
ensembl
ENSRNOG00065015941
resolver
genesymbol
Anxa2
resolver
genesymbol_syn
Anx2
resolver
uniprot_entry
ANXA2_RAT
resolver
amino_acid_sequence
MSTVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELPSAMKSALSGHLETVMLGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGEFRKLLVALAKGKRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYFIQQDTKGDYQKALLYLCGGDD
uniprot
proteins
function
FUNCTION: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07355, ECO:0000250|UniProtKB:P07356}.
uniprot
proteins
mass_dalton
38678
uniprot
proteins
post_translational_modification
PTM: ISGylated. {ECO:0000250}.
uniprot
proteins
protein_family
Annexin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1618851
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8092993
uniprot
proteins
pubmed
8389036
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:1618851}. Melanosome {ECO:0000250}. Note=In the lamina beneath the plasma membrane.
uniprot
proteins