Gpr55
entrez
227326
canonical
uniprot
Q3UJF0
canonical
ensembl
ENSMUSG00000049608
resolver
ensp
ENSMUSP00000084196
resolver
ensp
ENSMUSP00000176608
resolver
ensp
ENSMUSP00000176609
resolver
enst
ENSMUST00000086975
resolver
genesymbol
Gpr55
resolver
genesymbol_syn
Gm218
resolver
uniprot
Q14BV9
resolver
uniprot_entry
GPR55_MOUSE
resolver
uniprot_entry
Q14BV9_MOUSE
resolver
amino_acid_sequence
MSQPERDNCSFDSVDKLTRTLQLAVHIPTFLLGLVLNLLAIRGFSAFLKKRKLDYIATSIYMINLAVFDLLLVLSLPFKMVLPQVESPLPSFCTLVECLYFISMYGSVFTICFISLDRFLAIQYPILASHLRSPRKTFGICCIIWMLVWIGSIPIYTFHREVERYKCFHNMSDVTWSASVFFPLEIFGFLLPMGIMGFCSYRSIHILLRRPDSTEDWVQQRDTKGWVQKRACIWTIATNLVIFVVSFLPVHLGFFLQYLVRNRFILDCRMKQGISLFLQLSLCFSNINCCLDVFCYYFVIKEFRMRIKAHRPSTIKLVNQDTMVSRG
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Induces the Ca(2+) release from intracellular stores via ERK, the heterotrimeric G protein GNA13 and RHOA leading to morphological changes including cell rounding and stress fiber formation. In macrophages, acts downstream of lysophosphatidylglucoside to inhibit the translocation of the phospholipid-transporting ABCA1 to plasma membrane and subsequent cholesterol efflux leading to lipid accumulation and foam cell formation. May be involved in hyperalgesia associated with inflammatory and neuropathic pain (PubMed:18502582). {ECO:0000250|UniProtKB:Q9Y2T6, ECO:0000269|PubMed:18502582}.
uniprot
proteins
mass_dalton
38090
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18502582
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
36523570
uniprot
proteins
pubmed
36898418
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 58..78; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 137..157; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 180..200; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 240..260; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 280..300; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins