Efna2
entrez
13637
canonical
uniprot
P52801
canonical
ensembl
ENSMUSG00000003070
resolver
ensp
ENSMUSP00000003154
resolver
enst
ENSMUST00000003154
resolver
genesymbol
Efna2
resolver
genesymbol_syn
Elf1
resolver
genesymbol_syn
Epl6
resolver
genesymbol_syn
Eplg6
resolver
genesymbol_syn
Lerk6
resolver
uniprot
Q3USB4
resolver
uniprot_entry
EFNA2_MOUSE
resolver
uniprot_entry
Q3USB4_MOUSE
resolver
amino_acid_sequence
MAPAQRPLLPLLLLLLPLRARNEDPARANADRYAVYWNRSNPRFQVSAVGDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMERYILYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNLVDRPCLRLKVYVRPTNETLYEAPEPIFTSNSSCSGLGGCHLFLTTVPVLWSLLGS
uniprot
proteins
function
FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:19299512, ECO:0000269|PubMed:9053851}.
uniprot
proteins
mass_dalton
23586
uniprot
proteins
protein_family
Ephrin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19299512
uniprot
proteins
pubmed
27446912
uniprot
proteins
pubmed
7522971
uniprot
proteins
pubmed
7876076
uniprot
proteins
pubmed
9053851
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
uniprot
proteins