Hdac9
entrez
79221
canonical
uniprot
Q99N13
canonical
ensembl
ENSMUSG00000004698
resolver
ensp
ENSMUSP00000106443
resolver
ensp
ENSMUSP00000147395
resolver
ensp
ENSMUSP00000147519
resolver
ensp
ENSMUSP00000147903
resolver
ensp
ENSMUSP00000148029
resolver
ensp
ENSMUSP00000148224
resolver
ensp
ENSMUSP00000159253
resolver
ensp
ENSMUSP00000159264
resolver
ensp
ENSMUSP00000274779
resolver
ensp
ENSMUSP00000274781
resolver
ensp
ENSMUSP00000274793
resolver
enst
ENSMUST00000110819
resolver
enst
ENSMUST00000209750
resolver
enst
ENSMUST00000209902
resolver
enst
ENSMUST00000209990
resolver
enst
ENSMUST00000239340
resolver
genesymbol
Hdac9
resolver
genesymbol_syn
Hdac7b
resolver
genesymbol_syn
Hdrp
resolver
genesymbol_syn
Mitr
resolver
uniprot
A0A0R4J1F3
resolver
uniprot
A0A1B0GR65
resolver
uniprot
A0A1B0GRH0
resolver
uniprot
A0A1B0GSQ5
resolver
uniprot
A0A668KM95
resolver
uniprot
Q4QQN7
resolver
uniprot
Q8R4Y6
resolver
uniprot
Q9EPT2
resolver
uniprot_entry
A0A0R4J1F3_MOUSE
resolver
uniprot_entry
A0A1B0GR65_MOUSE
resolver
uniprot_entry
A0A1B0GRH0_MOUSE
resolver
uniprot_entry
A0A1B0GSQ5_MOUSE
resolver
uniprot_entry
A0A668KM95_MOUSE
resolver
uniprot_entry
HDAC9_MOUSE
resolver
uniprot_sec
Q4QQN7
resolver
uniprot_sec
Q8R4Y6
resolver
uniprot_sec
Q9EPT2
resolver
amino_acid_sequence
MHSMISSVDVKSEVPMGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVGRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDSKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNLVTSFKKRVFEVAESSVSSSSPGSGPSSPNNGPAGNVTENEASALPPTPHPEQLVPQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSPLNASNSLKDKQKCETQMLRQGVPLPSQYGSSIAASSSHVHVAMEGKPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQSMEDRAASKDNSARSDSSACVEDTLGQVGAVKVKEEPVDSDEDAQIQEMECGEQAAFMQQVIGKDLAPGFVIKVII
uniprot
proteins
ec_number
3.5.1.98
uniprot
proteins
function
FUNCTION: Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting HDAC1 and HDAC3. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription, inhibits skeletal myogenesis and may be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. {ECO:0000269|PubMed:11390982, ECO:0000269|PubMed:12202037, ECO:0000269|PubMed:15711539, ECO:0000269|PubMed:16611996}.
uniprot
proteins
mass_dalton
65687
uniprot
proteins
mutagenesis
MUTAGEN 25..26; /note="DL->AS: Abolishes binding to CTBP1 and impairs function in transcription repression."; /evidence="ECO:0000269|PubMed:11022042
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000250}.; PTM: Phosphorylated on Ser-220 and Ser-450; which promotes 14-3-3-binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240 by DYRK1B; which impairs nuclear accumulation. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. {ECO:0000269|PubMed:11390982, ECO:0000269|PubMed:12202037, ECO:0000269|PubMed:15546868}.
uniprot
proteins
protein_family
HD type 2 subfamily
uniprot
proteins
protein_family
Histone deacetylase family
uniprot
proteins
pubmed
11022042
uniprot
proteins
pubmed
11390982
uniprot
proteins
pubmed
12202037
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15546868
uniprot
proteins
pubmed
15567413
uniprot
proteins
pubmed
15711539
uniprot
proteins
pubmed
16611996
uniprot
proteins
pubmed
17101791
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11390982, ECO:0000269|PubMed:15546868, ECO:0000269|PubMed:15711539}.
uniprot
proteins