Ctss
entrez
50654
canonical
uniprot
Q02765
canonical
ensembl
ENSRNOG00000021157
resolver
ensp
ENSRNOP00000092901
resolver
enst
ENSRNOT00000105420
resolver
genesymbol
Ctss
resolver
uniprot
A0A8I6AES4
resolver
uniprot_entry
A0A8I6AES4_RAT
resolver
uniprot_entry
CATS_RAT
resolver
amino_acid_sequence
MAVLGAPGVLCDNGATAERPTLDHHWDLWKKTRMRRNTDQNEEDVRRLIWEKNLKFIMLHNLEHSMGMHSYSVGMNHMGDMTPEEVIGYMGSLRIPRPWNRSGTLKSSSNQTLPDSVDWREKGCVTNVKYQGSCGSCWAFSAEGALEGQLKLKTGKLVSLSAQNLVDCSTEEKYGNKGCGGGFMTEAFQYIIDTSIDSEASYPYKAMDEKCLYDPKNRAATCSRYIELPFGDEEALKEAVATKGPVSVGIDDASHSSFFLYQSGVYDDPSCTENMNHGVLVVGYGTLDGKDYWLVKNSWGLHFGDQGYIRMARNNKNHCGIASYCSYPEI
uniprot
proteins
ec_number
3.4.22.27
uniprot
proteins
function
FUNCTION: Thiol protease (By similarity). Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity). Elicits itch by mediating cleavage and activation of MRGPRX1 (By similarity). {ECO:0000250|UniProtKB:O70370, ECO:0000250|UniProtKB:P25774}.
uniprot
proteins
mass_dalton
36833
uniprot
proteins
protein_family
Peptidase C1 family
uniprot
proteins
pubmed
1281481
uniprot
proteins
sequence_length
330
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:P25774}. Secreted {ECO:0000250|UniProtKB:P25774}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P25774}.
uniprot
proteins