Arpp19
entrez
59046
canonical
uniprot
P56212
canonical
ensembl
ENSMUSG00000007656
resolver
ensp
ENSMUSP00000007800
resolver
ensp
ENSMUSP00000125825
resolver
ensp
ENSMUSP00000131597
resolver
ensp
ENSMUSP00000132350
resolver
genesymbol
Arpp19
resolver
uniprot
Q543L2
resolver
uniprot_entry
ARP19_MOUSE
resolver
uniprot_sec
Q543L2
resolver
amino_acid_sequence
MSAEVPEAASAEEQKEMEDKVTSPEKAEEAKLKARYPHLGQKPGGSDFLRKRLQKGQKYFDSGDYNMAKAKMKNKQLPAAAPDKTEVTGDHIPTPQDLPQRKPSLVASKLAG
uniprot
proteins
function
FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis (By similarity). Inhibition of PP2A is enhanced when ARPP19 is phosphorylated (By similarity). When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA (By similarity). {ECO:0000250|UniProtKB:P56211, ECO:0000250|UniProtKB:Q712U5}.
uniprot
proteins
mass_dalton
12293
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-62 by MASTL/GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated at Ser-104 by PKA (By similarity). Phosphorylated at Ser-62 by MAST3 (By similarity). Phosphorylation by PKA and MAST3 is mutually antagonistic, with each kinase inhibiting phosphorylation by the other (By similarity). {ECO:0000250|UniProtKB:P56211, ECO:0000250|UniProtKB:Q6DEB4, ECO:0000269|PubMed:11279279, ECO:0000269|PubMed:2845422}.
uniprot
proteins
protein_family
Endosulfine family
uniprot
proteins
pubmed
11279279
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2845422
uniprot
proteins
sequence_length
112
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins