Nceh1
entrez
320024
canonical
uniprot
Q8BLF1
canonical
ensembl
ENSMUSG00000027698
resolver
ensp
ENSMUSP00000045864
resolver
enst
ENSMUST00000046515
resolver
genesymbol
Nceh1
resolver
genesymbol_syn
Aadacl1
resolver
genesymbol_syn
Kiaa1363
resolver
uniprot
Q69ZL0
resolver
uniprot
Q8BZK3
resolver
uniprot_entry
NCEH1_MOUSE
resolver
uniprot_sec
Q69ZL0
resolver
uniprot_sec
Q8BZK3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by bulky trifluoromethyl ketones. {ECO:0000269|PubMed:12740587}.
uniprot
proteins
amino_acid_sequence
MRSSCVLLAALLALAAYYVYIPLPSAVSDPWKLMLLDATFRGAQQVSNLIHSLGLNHHLIALNFIITSFGKQSARSSPKVKVTDTDFDGVEVRVFEGSPKPEEPLRRSVIYIHGGGWALASAKISYYDQLCTTMAEELNAVIVSIEYRLVPQVYFPEQIHDVIRATKYFLQPEVLDKYKVDPGRVGISGDSAGGNLAAALGQQFTYVASLKNKLKLQALVYPVLQALDFNTPSYQQSMNTPILPRHVMVRYWLDYFKGNYDFVEAMIVNNHTSLDVERAAALRARLDWTSLLPSSIKKNYKPIMQTTGNARIVQEIPQLLDAAASPLIAEQEVLEALPKTYILTCEHDVLRDDGIMYAKRLESAGVNVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL
uniprot
proteins
ec_number
3.1.1.-
uniprot
proteins
ec_number
3.1.1.71
uniprot
proteins
function
FUNCTION: Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed:18164358, PubMed:20625037). May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (PubMed:18782767). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (PubMed:15840715, PubMed:16978018, PubMed:18164358). {ECO:0000269|PubMed:15840715, ECO:0000269|PubMed:16978018, ECO:0000269|PubMed:18164358, ECO:0000269|PubMed:18782767, ECO:0000269|PubMed:20625037}.
uniprot
proteins
mass_dalton
45740
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:12740587}.
uniprot
proteins
protein_family
'GDXG' lipolytic enzyme family
uniprot
proteins
pubmed
12740587
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15840715
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16978018
uniprot
proteins
pubmed
18164358
uniprot
proteins
pubmed
18782767
uniprot
proteins
pubmed
20625037
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
408
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6PIU2}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q6PIU2}. Microsome {ECO:0000269|PubMed:18782767}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins