Arhgap44
entrez
216831
canonical
uniprot
Q5SSM3
canonical
ensembl
ENSMUSG00000033389
resolver
ensp
ENSMUSP00000039139
resolver
ensp
ENSMUSP00000090681
resolver
ensp
ENSMUSP00000115612
resolver
ensp
ENSMUSP00000224749
resolver
ensp
ENSMUSP00000224750
resolver
ensp
ENSMUSP00000224756
resolver
genesymbol
Arhgap44
resolver
genesymbol_syn
Rich2
resolver
uniprot
Q5SSM4
resolver
uniprot
Q5SSM6
resolver
uniprot
Q5SSM7
resolver
uniprot
Q7TNB9
resolver
uniprot
Q8BW90
resolver
uniprot_entry
RHG44_MOUSE
resolver
uniprot_sec
Q5SSM4
resolver
uniprot_sec
Q5SSM6
resolver
uniprot_sec
Q5SSM7
resolver
uniprot_sec
Q7TNB9
resolver
uniprot_sec
Q8BW90
resolver
amino_acid_sequence
MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLVEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLMISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNIQEQDKRLQALWNACEKLPKANHNNIKYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQSEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNLTGSYGSPVHVNHNANYSSMPSPDMDPADRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTSWVARRGSSAGRKASCAPPSMQPPAPPSELAAPLPSPLPEQVPDSPATPAPALSPSGASLQPTPERPSVSKSKELSPGSGQKGSPGSIQGTPCPGTQLGPQPAASPSQLPADQSPHTLRKVSKKVAPIPPKVPFVQPGTVSDQPVGQPSPVSLSPTPPSTPSPYGLSYPPGYSMASGQLSPASAPPLASPSVFTSTLAKSRPTPKPRQRPTLPPPQPPSVSLSASSPQSTEHPMLDGMSPGESMSTDLVHFDVPSIHIELGSTLRLSPLEHARRHSATDKRDSEEESESTAL
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:24352656, PubMed:26969129). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (PubMed:23739967, PubMed:24352656, PubMed:26969129). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (PubMed:23739967). {ECO:0000250|UniProtKB:F1LQX4, ECO:0000269|PubMed:23739967, ECO:0000269|PubMed:24352656, ECO:0000269|PubMed:26969129}.
uniprot
proteins
mass_dalton
88994
uniprot
proteins
mutagenesis
MUTAGEN 291; /note="R->A: Reduces GRIA1 recycling. Abolishes the increase of spine density and size, as well as reduces the increase of GRIA1 expression in surface associated with long-term potentiation."; /evidence="ECO:0000269|PubMed:23739967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23739967
uniprot
proteins
pubmed
24352656
uniprot
proteins
pubmed
26969129
uniprot
proteins
sequence_length
814
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendritic spine {ECO:0000269|PubMed:23739967, ECO:0000269|PubMed:24352656}. Recycling endosome {ECO:0000269|PubMed:23739967}. Presynapse {ECO:0000269|PubMed:23739967}. Cell projection, dendrite {ECO:0000250|UniProtKB:F1LQX4}. Note=In CA1 hippocampal synapses, detected at both presynaptic and postsynaptic sites (PubMed:23739967). Located in convoluted dendritic plasma membrane sections enriched in polymerized actin and myosin (patches) along dendrites where often emerge filopodia (By similarity). {ECO:0000250|UniProtKB:F1LQX4, ECO:0000269|PubMed:23739967}.
uniprot
proteins