Pafah1b1
entrez
83572
canonical
uniprot
P63004
canonical
ensembl
ENSRNOG00000002755
resolver
ensembl
ENSRNOG00055027078
resolver
ensembl
ENSRNOG00060028693
resolver
ensembl
ENSRNOG00065021007
resolver
ensp
ENSRNOP00000003696
resolver
ensp
ENSRNOP00055038439
resolver
ensp
ENSRNOP00060041591
resolver
ensp
ENSRNOP00065028762
resolver
enst
ENSRNOT00000003696
resolver
enst
ENSRNOT00055046805
resolver
enst
ENSRNOT00060049883
resolver
enst
ENSRNOT00065035688
resolver
genesymbol
Pafah1b1
resolver
genesymbol_syn
Lis-1
resolver
genesymbol_syn
Lis1
resolver
genesymbol_syn
Pafaha
resolver
uniprot
O35592
resolver
uniprot
P43035
resolver
uniprot
P81692
resolver
uniprot
Q9R2A6
resolver
uniprot_entry
LIS1_RAT
resolver
uniprot_sec
O35592
resolver
uniprot_sec
P43035
resolver
uniprot_sec
P81692
resolver
uniprot_sec
Q9R2A6
resolver
amino_acid_sequence
MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR
uniprot
proteins
function
FUNCTION: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (By similarity). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity). {ECO:0000250|UniProtKB:P43033, ECO:0000250|UniProtKB:P43034, ECO:0000250|UniProtKB:P63005, ECO:0000269|PubMed:11056532, ECO:0000269|PubMed:16144905}.
uniprot
proteins
mass_dalton
46670
uniprot
proteins
protein_family
WD repeat LIS1/nudF family
uniprot
proteins
pubmed
11001923
uniprot
proteins
pubmed
11056530
uniprot
proteins
pubmed
11056532
uniprot
proteins
pubmed
11163260
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16144905
uniprot
proteins
pubmed
16481446
uniprot
proteins
pubmed
9459487
uniprot
proteins
pubmed
9660828
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03141}. Cytoplasm, cytoskeleton, spindle {ECO:0000255|HAMAP-Rule:MF_03141}. Nucleus membrane {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes (By similarity). Redistributes to axons during neuronal development. {ECO:0000255|HAMAP-Rule:MF_03141, ECO:0000269|PubMed:11001923, ECO:0000269|PubMed:11056530, ECO:0000269|PubMed:16481446}.
uniprot
proteins