Ncdn
entrez
89791
canonical
uniprot
O35095
canonical
ensembl
ENSRNOG00000011751
resolver
ensp
ENSRNOP00000016229
resolver
enst
ENSRNOT00000016230
resolver
genesymbol
Ncdn
resolver
uniprot
Q5PQW2
resolver
uniprot_entry
NCDN_RAT
resolver
uniprot_sec
Q5PQW2
resolver
amino_acid_sequence
MSCCDLAAAGQLGKAGIMASDCEPALNQAESRNPTLERYLGALREAKNDSEQFAALLLVTKAVKAGDIDAKTRRRIFDAVGFTFPNRLLTTKEAPDGCPDHVLRALGVALLACFCSDPELASHPQVLNKIPILCTFLTARGDPDDAARRSMIDDTYQCLTAVAGTPRGPRHLIAGGTVSALCQAYLGHGYGFDQALALLVGLLAAAETQCWKEAEPDLLAVLRGLSEDFQRAEDASKFELCQLLPLFLPPTTVPPECHRDLQAGLARILGSKLSSWQRNPALKLAARLAHACGSDWIPVGSSGSKFLALLVNLACVEVRLALEETGTEVKEDVVTACYALMELGIQECTRCEQSLLKEPQKVQLVSIMKEAIGAVIHYLLRVGPEKQKEPFVFASVRILGAWLAEETSSLRKEVCQLLPFLVRYAKTLYEEAEEASDISQQVANLAISPTTPGPAWPGDALRLLLPGWCHLTVEDGPREILIKEGAPSLLCKYFLQQWELTSPGHDTSVLPDSVEIGLQTCCHIFLNLVVTAPGLIKRDACFTSLMNTLMTSLPSLVQQQGRLLLAANVATLGLLMARLLSTSPALQGTPASRGFFAAAILFLSQSHVARATPGSDQAVLALSPDYEGIWADLQELWFLGMQAFTGCVPLLPWLAPAALRSRWPQELLQLLGSVSPNSVKPEMVAAYQGVLVELARANRLCREAMRLQAGEETASHYRMAALEQCLSEP
uniprot
proteins
function
FUNCTION: Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. {ECO:0000269|PubMed:9398642}.
uniprot
proteins
mass_dalton
78923
uniprot
proteins
mutagenesis
MUTAGEN 3; /note="C->S: Loss of palmitoylation."; /evidence="ECO:0000269|PubMed:23687301"; MUTAGEN 4; /note="C->S: Loss of palmitoylation."; /evidence="ECO:0000269|PubMed:23687301
uniprot
proteins
post_translational_modification
PTM: Palmitoylated (PubMed:23687301). Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes (PubMed:23687301). May also be palmitoylated by ZDHHC7 (PubMed:23687301). {ECO:0000269|PubMed:23687301}.
uniprot
proteins
protein_family
Neurochondrin family
uniprot
proteins
pubmed
10521593
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18572016
uniprot
proteins
pubmed
20007903
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23687301
uniprot
proteins
pubmed
9398642
uniprot
proteins
sequence_length
729
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10521593}. Endosome membrane {ECO:0000269|PubMed:23687301}; Lipid-anchor {ECO:0000305|PubMed:23687301}. Cell projection, dendrite {ECO:0000269|PubMed:10521593, ECO:0000269|PubMed:23687301}. Postsynapse {ECO:0000269|PubMed:23687301}. Note=Localizes to somatic regions of neurons (PubMed:10521593, PubMed:23687301). Localization to endosome membrane requires palmitoylation (PubMed:23687301). {ECO:0000269|PubMed:10521593, ECO:0000269|PubMed:23687301}.
uniprot
proteins