Clec5a
entrez
23845
canonical
uniprot
Q9R007
canonical
ensembl
ENSMUSG00000029915
resolver
ensp
ENSMUSP00000099030
resolver
ensp
ENSMUSP00000121848
resolver
genesymbol
Clec5a
resolver
genesymbol_syn
Clecsf5
resolver
genesymbol_syn
Mdl1
resolver
uniprot
Q3SXC9
resolver
uniprot
Q3UV97
resolver
uniprot
Q8BL24
resolver
uniprot_entry
CLC5A_MOUSE
resolver
uniprot_sec
Q3SXC9
resolver
uniprot_sec
Q3UV97
resolver
uniprot_sec
Q8BL24
resolver
amino_acid_sequence
MNWHMIISGLIVVVIKVVGMTFFLLYFPQVFGKSNDGFVPTESYGTTSVQNVSQIFGRNDESTMPTRSYGTVCPRNWDFHQGKCFFFSFSESPWKDSMDYCATQGSTLAIVNTPEKLKYLQDIAGIENYFIGLVRQPGEKKWRWINNSVFNGNVTNQDQNFDCVTIGLTKTYDAASCEVSYRWICEMNAK
uniprot
proteins
disease_involvement
DISEASE: Note=Involved in the pathogenetic mechanisms of Japanese encephalitis virus (JEV) infection of the brain. JEV infection of young mice results in increased expression of CLEC5A in spleen and brain with consequent activation of proinflammatory cytokine secretion. {ECO:0000269|PubMed:20637688}.
uniprot
proteins
function
FUNCTION: Functions as a positive regulator of osteoclastogenesis (PubMed:19251634). Cell surface receptor that signals via TYROBP (PubMed:10449773). Regulates inflammatory responses (PubMed:20212065). {ECO:0000269|PubMed:10449773, ECO:0000269|PubMed:19251634, ECO:0000269|PubMed:20212065}.
uniprot
proteins
mass_dalton
21696
uniprot
proteins
post_translational_modification
PTM: N-glycosylated (PubMed:19074552, PubMed:19251634). Contains sialic acid residues (PubMed:19074552). {ECO:0000269|PubMed:19074552, ECO:0000269|PubMed:19251634}.
uniprot
proteins
pubmed
10449773
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19074552
uniprot
proteins
pubmed
19251634
uniprot
proteins
pubmed
20212065
uniprot
proteins
pubmed
20637688
uniprot
proteins
sequence_length
190
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19074552}; Single-pass type II membrane protein {ECO:0000269|PubMed:19074552}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins