Dnajc27
entrez
217378
canonical
uniprot
Q8CFP6
canonical
ensembl
ENSMUSG00000020657
resolver
ensp
ENSMUSP00000020986
resolver
ensp
ENSMUSP00000106803
resolver
ensp
ENSMUSP00000151848
resolver
ensp
ENSMUSP00000218928
resolver
ensp
ENSMUSP00000218935
resolver
enst
ENSMUST00000020986
resolver
enst
ENSMUST00000049584
resolver
enst
ENSMUST00000219923
resolver
genesymbol
Dnajc27
resolver
genesymbol_syn
Rabj
resolver
genesymbol_syn
Rbj
resolver
uniprot
Q8BX00
resolver
uniprot
Q923I0
resolver
uniprot_entry
DJC27_MOUSE
resolver
uniprot_sec
Q8BX00
resolver
uniprot_sec
Q923I0
resolver
amino_acid_sequence
METNVPKRKEPAKSLRIKVISMGNAEVGKSCIIKRYCEKRFVSKYLATIGIDYGVTKVQVRDREIKVNIFDMAGHPFFFEVRNEFYKDTQGVILVYDVGQKDSFDALDSWLAEMKQELGPHGNMDNIVFVVCANKIDCSKHRCIDESEGRLWAESKGFLYFETSAQTGEGINEMFQTFYLSIVDLCENGGKRPTASSSASFTKEQADTIRRIRNSKDSWEMLGVRPGASREEVNKAYRKLAVLLHPDKCVAPGSEDAFKAVVNARTALLKNIK
uniprot
proteins
function
FUNCTION: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. {ECO:0000269|PubMed:24746703}.
uniprot
proteins
mass_dalton
30831
uniprot
proteins
mutagenesis
MUTAGEN 30; /note="S->N: Abolishes GTP binding."; /evidence="ECO:0000269|PubMed:24746703"; MUTAGEN 75; /note="H->L: Abolishes GTPase activity."; /evidence="ECO:0000269|PubMed:24746703"; MUTAGEN 75; /note="H->Q: Increases GTPase activity."; /evidence="ECO:0000269|PubMed:24746703
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
14980719
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24746703
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24746703}.
uniprot
proteins