NDN
entrez
4692
canonical
uniprot
Q99608
canonical
ensembl
ENSG00000182636
resolver
ensp
ENSP00000497916
resolver
enst
ENST00000649030
resolver
genesymbol
NDN
resolver
hgnc
HGNC:7675
resolver
uniprot
B2R6Z5
resolver
uniprot
X5D982
resolver
uniprot_entry
NECD_HUMAN
resolver
uniprot_entry
X5D982_HUMAN
resolver
uniprot_sec
B2R6Z5
resolver
amino_acid_sequence
MSEQSKDLSDPNFAAEAPNSEVHSSPGVSEGVPPSATLAEPQSPPLGPTAAPQAAPPPQAPNDEGDPKALQQAAEEGRAHQAPSAAQPGPAPPAPAQLVQKAHELMWYVLVKDQKKMIIWFPDMVKDVIGSYKKWCRSILRRTSLILARVFGLHLRLTSLHTMEFALVKALEPEELDRVALSNRMPMTGLLLMILSLIYVKGRGARESAVWNVLRILGLRPWKKHSTFGDVRKLITEEFVQMNYLKYQRVPYVEPPEYEFFWGSRASREITKMQIMEFLARVFKKDPQAWPSRYREALEEARALREANPTAHYPRSSVSED
uniprot
proteins
function
FUNCTION: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
36086
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21543378
uniprot
proteins
pubmed
9354807
uniprot
proteins
pubmed
9630521
uniprot
proteins
sequence_length
321
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Perikaryon. Nucleus. Note=Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix.
uniprot
proteins