MREG
entrez
55686
canonical
uniprot
Q8N565
canonical
ensembl
ENSG00000118242
resolver
ensp
ENSP00000263268
resolver
ensp
ENSP00000411076
resolver
genesymbol
MREG
resolver
genesymbol_syn
DSU
resolver
hgnc
HGNC:25478
resolver
uniprot
Q53R89
resolver
uniprot
Q53TC1
resolver
uniprot
Q5XKB6
resolver
uniprot
Q9NWC9
resolver
uniprot
Q9P1S1
resolver
uniprot_entry
MREG_HUMAN
resolver
uniprot_sec
Q53R89
resolver
uniprot_sec
Q53TC1
resolver
uniprot_sec
Q5XKB6
resolver
uniprot_sec
Q9NWC9
resolver
uniprot_sec
Q9P1S1
resolver
amino_acid_sequence
MGLRDWLRTVCCCCGCECLEERALPEKEPLVSDNNPYSSFGATLVRDDEKNLWSMPHDVSHTEADDDRTLYNLIVIRNQQAKDSEEWQKLNYDIHTLRQVRREVRNRWKCILEDLGFQKEADSLLSVTKLSTISDSKNTRKAREMLLKLAEETNIFPTSWELSERYLFVVDRLIALDAAEEFFKLARRTYPKKPGVPCLADGQKELHYLPFPSP
uniprot
proteins
function
FUNCTION: Probably functions as a cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (By similarity). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity). {ECO:0000250|UniProtKB:Q6NVG5, ECO:0000269|PubMed:19240024}.
uniprot
proteins
mass_dalton
24927
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Palmitoylation is required to maintain the protein at the melanosome membrane. {ECO:0000250|UniProtKB:Q6NVG5}.
uniprot
proteins
protein_family
Melanoregulin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17260955
uniprot
proteins
pubmed
19240024
uniprot
proteins
pubmed
21406692
uniprot
proteins
sequence_length
214
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q6NVG5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NVG5}. Melanosome membrane {ECO:0000250|UniProtKB:Q6NVG5}; Lipid-anchor {ECO:0000250|UniProtKB:Q6NVG5}. Lysosome membrane {ECO:0000250|UniProtKB:Q6NVG5}; Lipid-anchor {ECO:0000250|UniProtKB:Q6NVG5}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q6NVG5}. Note=Localizes to the inner segment and basal outer segment of rods in the retina. {ECO:0000250|UniProtKB:Q6NVG5}.
uniprot
proteins