TRIM36
entrez
55521
canonical
uniprot
Q9NQ86
canonical
ensembl
ENSG00000152503
resolver
ensp
ENSP00000282369
resolver
ensp
ENSP00000368937
resolver
ensp
ENSP00000368938
resolver
ensp
ENSP00000423934
resolver
ensp
ENSP00000424259
resolver
ensp
ENSP00000655548
resolver
enst
ENST00000514154
resolver
genesymbol
TRIM36
resolver
genesymbol_syn
RBCC728
resolver
genesymbol_syn
RNF98
resolver
hgnc
HGNC:16280
resolver
uniprot
A1L3Z1
resolver
uniprot
A6NDD0
resolver
uniprot
B7Z3V4
resolver
uniprot
B7ZAV7
resolver
uniprot
E9PBG3
resolver
uniprot
E9PFI8
resolver
uniprot
Q0P5Z9
resolver
uniprot
Q4R1Q4
resolver
uniprot_entry
E9PBG3_HUMAN
resolver
uniprot_entry
Q4R1Q4_HUMAN
resolver
uniprot_entry
TRI36_HUMAN
resolver
uniprot_sec
A1L3Z1
resolver
uniprot_sec
A6NDD0
resolver
uniprot_sec
B7Z3V4
resolver
uniprot_sec
B7ZAV7
resolver
uniprot_sec
E9PFI8
resolver
uniprot_sec
Q0P5Z9
resolver
amino_acid_sequence
MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKELLLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPGWKRNSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM
uniprot
proteins
disease_involvement
DISEASE: Anencephaly 1 (ANPH1) [MIM:206500]: An extreme form of neural tube defect resulting in the absence of brain tissues, and death in utero or perinatally. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed. ANPH1 inheritance is autosomal recessive. {ECO:0000269|PubMed:28087737}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins including CTNNB1, FOXA2 and AKT1 (PubMed:35768649, PubMed:37875418, PubMed:41323265). Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. Inhibits lung fibroblast proliferation, migration, and differentiation. Mechanistically, mediates 'Lys-48'-linked polyubiquitination of phospho-AKT1, leading to its proteasomal degradation and consequent inhibition of AKT signaling (PubMed:41323265). Promotes apoptosis via inhibition of the Wnt/beta-catenin signaling pathway (PubMed:35768649). Regulates ferroptosis by ubiquitinating and degrading FOXA2 (PubMed:37875418). {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737, ECO:0000269|PubMed:35768649, ECO:0000269|PubMed:37875418, ECO:0000269|PubMed:41323265}.
uniprot
proteins
mass_dalton
83013
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="C->A: Complete loss of activity; when associated with A-36."; /evidence="ECO:0000269|PubMed:41323265"; MUTAGEN 36; /note="C->A: Complete loss of activity; when associated with A-33."; /evidence="ECO:0000269|PubMed:41323265
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15145053
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28087737
uniprot
proteins
pubmed
35768649
uniprot
proteins
pubmed
37875418
uniprot
proteins
pubmed
40821731
uniprot
proteins
pubmed
41323265
uniprot
proteins
sequence_length
728
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28087737, ECO:0000269|PubMed:37875418}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q80WG7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q80WG7}. Note=Found in the acrosomal region of elongated spermatids and mature sperm. {ECO:0000250|UniProtKB:Q80WG7}.
uniprot
proteins