GAPVD1
entrez
26130
canonical
uniprot
Q14C86
canonical
ensembl
ENSG00000165219
resolver
ensp
ENSP00000297933
resolver
ensp
ENSP00000309582
resolver
ensp
ENSP00000377645
resolver
ensp
ENSP00000377646
resolver
ensp
ENSP00000377665
resolver
ensp
ENSP00000419063
resolver
ensp
ENSP00000419767
resolver
ensp
ENSP00000419799
resolver
ensp
ENSP00000558141
resolver
ensp
ENSP00000558142
resolver
ensp
ENSP00000558144
resolver
ensp
ENSP00000607726
resolver
ensp
ENSP00000607727
resolver
ensp
ENSP00000607729
resolver
ensp
ENSP00000607732
resolver
ensp
ENSP00000607733
resolver
ensp
ENSP00000607734
resolver
ensp
ENSP00000607736
resolver
ensp
ENSP00000607737
resolver
enst
ENST00000394083
resolver
enst
ENST00000394084
resolver
enst
ENST00000497580
resolver
enst
ENST00000937677
resolver
enst
ENST00000937678
resolver
genesymbol
GAPVD1
resolver
genesymbol_syn
GAPEX5
resolver
genesymbol_syn
KIAA1521
resolver
genesymbol_syn
RAP6
resolver
hgnc
HGNC:23375
resolver
uniprot
A8MYK3
resolver
uniprot
B0QZ62
resolver
uniprot
B0QZ63
resolver
uniprot
B0QZ64
resolver
uniprot
B0QZ65
resolver
uniprot
B4DGD8
resolver
uniprot
F6WC36
resolver
uniprot
F8W9S7
resolver
uniprot
Q14C76
resolver
uniprot
Q2Q1W1
resolver
uniprot
Q8ND92
resolver
uniprot
Q8WU86
resolver
uniprot
Q96CZ4
resolver
uniprot
Q9NXQ1
resolver
uniprot
Q9P207
resolver
uniprot
Q9Y4N0
resolver
uniprot_entry
B0QZ65_HUMAN
resolver
uniprot_entry
B4DGD8_HUMAN
resolver
uniprot_entry
F6WC36_HUMAN
resolver
uniprot_entry
F8W9S7_HUMAN
resolver
uniprot_entry
GAPD1_HUMAN
resolver
uniprot_sec
A8MYK3
resolver
uniprot_sec
B0QZ62
resolver
uniprot_sec
B0QZ63
resolver
uniprot_sec
B0QZ64
resolver
uniprot_sec
Q14C76
resolver
uniprot_sec
Q2Q1W1
resolver
uniprot_sec
Q8ND92
resolver
uniprot_sec
Q8WU86
resolver
uniprot_sec
Q96CZ4
resolver
uniprot_sec
Q9NXQ1
resolver
uniprot_sec
Q9P207
resolver
uniprot_sec
Q9Y4N0
resolver
amino_acid_sequence
MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLIITSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKLNQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSILFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGSDRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVGEVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGDPRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNFMKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPIATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQLSDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELGAGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVLGSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVLPSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPNKIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAVVRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRSRSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGETEERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSPRLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDGESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLTHSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLLASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLESKEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERSVMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLSTVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
uniprot
proteins
function
FUNCTION: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. {ECO:0000269|PubMed:16410077}.
uniprot
proteins
mass_dalton
164980
uniprot
proteins
protein_family
GAPVD1 family
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16410077
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
32356940
uniprot
proteins
sequence_length
1478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:16410077}; Peripheral membrane protein {ECO:0000269|PubMed:16410077}. Endosome {ECO:0000269|PubMed:16410077}. Note=Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin.
uniprot
proteins