BECN2
entrez
441925
canonical
uniprot
A8MW95
canonical
ensembl
ENSG00000196289
resolver
ensp
ENSP00000488361
resolver
enst
ENST00000419583
resolver
genesymbol
BECN2
resolver
genesymbol_syn
BECN1L1
resolver
genesymbol_syn
BECN1P1
resolver
hgnc
HGNC:38606
resolver
uniprot
E9KNW0
resolver
uniprot_entry
BECN2_HUMAN
resolver
uniprot_sec
E9KNW0
resolver
amino_acid_sequence
MSSIRFLCQRCHQALKLSGSSESRSLPAAPAPTSGQAEPGDTREPGVTTREVTDAEEQQDGASSRSPPGDGSVSKGHANIFTLLGELGAMHMLSSIQKAAGDIFDIVSGQAVVDHPLCEECTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLTLANTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDVFLNNKYDRAMVAFLDCMQQFKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHLNTQELWTKALKFMLINFKWSLIWVASRYQK
uniprot
proteins
function
FUNCTION: Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G protein-coupled receptors turnover. Regulates degradation in lysosomes of a variety of G protein-coupled receptors via its interaction with GPRASP1/GASP1. {ECO:0000269|PubMed:23954414}.
uniprot
proteins
mass_dalton
48153
uniprot
proteins
mutagenesis
MUTAGEN 80; /note="I->S: Abolishes interaction with GPRASP1/GASP1 and ability to degrade G protein-coupled receptor. Does not affect function in autophagy."; /evidence="ECO:0000269|PubMed:23954414"; MUTAGEN 173; /note="E->L: Decreases homodimerization. Decreases interaction with ATG14."; /evidence="ECO:0000269|PubMed:28218432"; MUTAGEN 187; /note="N->L: Increases strongly homodimerization. Decreases interaction with ATG14."; /evidence="ECO:0000269|PubMed:28218432"; MUTAGEN 190; /note="A->L: Decreases interaction with ATG14. Increases slightly homodimerization; when associated with L-215."; /evidence="ECO:0000269|PubMed:28218432"; MUTAGEN 197; /note="A->L: Decreases interaction with ATG14. Probably strongly increases homodimerization; when associated with L-208."; /evidence="ECO:0000269|PubMed:28218432"; MUTAGEN 208; /note="E->L: Decreases interaction with ATG14. Probably strongly increases homodimerization; when associated with L-197."; /evidence="ECO:0000269|PubMed:28218432"; MUTAGEN 211; /note="H->L: Increases homodimerization. Decreases interaction with ATG14."; /evidence="ECO:0000269|PubMed:28218432"; MUTAGEN 215; /note="Y->L: Decreases interaction with ATG14. Increases slightly homodimerization; when associated with L-190."; /evidence="ECO:0000269|PubMed:28218432"; MUTAGEN 222; /note="Q->L: Decreases homodimerization. Decreases interaction with ATG14."; /evidence="ECO:0000269|PubMed:28218432"; MUTAGEN 243; /note="R->L: Decreases homodimerization. Decreases interaction with ATG14."; /evidence="ECO:0000269|PubMed:28218432
uniprot
proteins
protein_family
Beclin family
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
23954414
uniprot
proteins
pubmed
28218432
uniprot
proteins
sequence_length
431
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins