MKNK1
entrez
8569
canonical
uniprot
Q9BUB5
canonical
ensembl
ENSG00000079277
resolver
ensp
ENSP00000339573
resolver
ensp
ENSP00000361013
resolver
ensp
ENSP00000361014
resolver
ensp
ENSP00000411135
resolver
ensp
ENSP00000498143
resolver
ensp
ENSP00000568467
resolver
ensp
ENSP00000568468
resolver
ensp
ENSP00000568469
resolver
ensp
ENSP00000568471
resolver
ensp
ENSP00000568473
resolver
ensp
ENSP00000568475
resolver
ensp
ENSP00000568476
resolver
ensp
ENSP00000568477
resolver
ensp
ENSP00000568478
resolver
ensp
ENSP00000568481
resolver
ensp
ENSP00000568482
resolver
ensp
ENSP00000568484
resolver
ensp
ENSP00000568485
resolver
ensp
ENSP00000568486
resolver
ensp
ENSP00000568487
resolver
ensp
ENSP00000610411
resolver
ensp
ENSP00000610412
resolver
ensp
ENSP00000610413
resolver
ensp
ENSP00000637115
resolver
ensp
ENSP00000637117
resolver
ensp
ENSP00000637118
resolver
ensp
ENSP00000637119
resolver
ensp
ENSP00000637120
resolver
ensp
ENSP00000637122
resolver
ensp
ENSP00000637123
resolver
ensp
ENSP00000637125
resolver
ensp
ENSP00000637126
resolver
ensp
ENSP00000637128
resolver
ensp
ENSP00000637129
resolver
ensp
ENSP00000637131
resolver
ensp
ENSP00000637132
resolver
ensp
ENSP00000660677
resolver
ensp
ENSP00000715315
resolver
enst
ENST00000371945
resolver
enst
ENST00000428112
resolver
enst
ENST00000898408
resolver
enst
ENST00000898409
resolver
enst
ENST00000898410
resolver
enst
ENST00000898412
resolver
enst
ENST00000898414
resolver
enst
ENST00000898416
resolver
enst
ENST00000898417
resolver
enst
ENST00000898418
resolver
enst
ENST00000898419
resolver
enst
ENST00000898422
resolver
enst
ENST00000898423
resolver
enst
ENST00000898425
resolver
enst
ENST00000898426
resolver
enst
ENST00000898427
resolver
enst
ENST00000898428
resolver
enst
ENST00000940352
resolver
enst
ENST00000940353
resolver
enst
ENST00000940354
resolver
enst
ENST00000967056
resolver
enst
ENST00000967058
resolver
enst
ENST00000967059
resolver
enst
ENST00000967060
resolver
enst
ENST00000967061
resolver
enst
ENST00000967063
resolver
enst
ENST00000967064
resolver
enst
ENST00000967066
resolver
enst
ENST00000967067
resolver
enst
ENST00000967069
resolver
enst
ENST00000967070
resolver
enst
ENST00000967072
resolver
enst
ENST00000967073
resolver
genesymbol
MKNK1
resolver
genesymbol_syn
MNK1
resolver
hgnc
HGNC:7110
resolver
uniprot
A0A499FJN1
resolver
uniprot
A0A499FJS1
resolver
uniprot
A8K341
resolver
uniprot
D3DQ20
resolver
uniprot
D3DQ21
resolver
uniprot
O00312
resolver
uniprot
Q5TC06
resolver
uniprot
Q5TC07
resolver
uniprot
Q6V0N6
resolver
uniprot_entry
A0A499FJN1_HUMAN
resolver
uniprot_entry
A0A499FJS1_HUMAN
resolver
uniprot_entry
A8K341_HUMAN
resolver
uniprot_entry
MKNK1_HUMAN
resolver
uniprot_sec
D3DQ20
resolver
uniprot_sec
D3DQ21
resolver
uniprot_sec
O00312
resolver
uniprot_sec
Q5TC06
resolver
uniprot_sec
Q5TC07
resolver
uniprot_sec
Q6V0N6
resolver
activity_regulation
ACTIVITY REGULATION: Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway. {ECO:0000269|PubMed:9155018}.
uniprot
proteins
amino_acid_sequence
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}.
uniprot
proteins
mass_dalton
51342
uniprot
proteins
mutagenesis
MUTAGEN 78; /note="K->M: Loss of kinase activity; when associated with D-232."; /evidence="ECO:0000269|PubMed:11463832"; MUTAGEN 232; /note="D->A: Loss of kinase activity; when associated with K-78."; /evidence="ECO:0000269|PubMed:11463832"; MUTAGEN 250; /note="T->A: Loss of kinase activity; when associated with T-255."; /evidence="ECO:0000269|PubMed:11463832"; MUTAGEN 255; /note="T->A: Loss of kinase activity; when associated with T-250."; /evidence="ECO:0000269|PubMed:11463832"; MUTAGEN 385; /note="T->D: Constitutively active."; /evidence="ECO:0000269|PubMed:11463832
uniprot
proteins
post_translational_modification
PTM: Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11463832
uniprot
proteins
pubmed
15234964
uniprot
proteins
pubmed
15350534
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9155018
uniprot
proteins
pubmed
9878069
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus.
uniprot
proteins