Ints8
entrez
72656
canonical
uniprot
Q80V86
canonical
ensembl
ENSMUSG00000040738
resolver
ensp
ENSMUSP00000038418
resolver
ensp
ENSMUSP00000103955
resolver
enst
ENSMUST00000044616
resolver
enst
ENSMUST00000108319
resolver
genesymbol
Ints8
resolver
uniprot
A2API4
resolver
uniprot
Q3TEM3
resolver
uniprot
Q3TNW0
resolver
uniprot
Q6PFD3
resolver
uniprot
Q810I3
resolver
uniprot
Q8BQJ8
resolver
uniprot
Q8BT91
resolver
uniprot_entry
INT8_MOUSE
resolver
uniprot_sec
A2API4
resolver
uniprot_sec
Q3TEM3
resolver
uniprot_sec
Q3TNW0
resolver
uniprot_sec
Q6PFD3
resolver
uniprot_sec
Q810I3
resolver
uniprot_sec
Q8BQJ8
resolver
uniprot_sec
Q8BT91
resolver
amino_acid_sequence
MSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKACPDPAPVQLIVQFLEQASKPSVNEQNQVQPPPDNKRNRVLKLLALKVAAHLKWDLDILEKSLSVPVLNMLLNELLCISKVPPGTKHVDMDLSALPPTTAMAILLYNRWAIRTIVQSSFPVKQAKPGPPQLNVMNQMQQEKELTENILKVLKEQAADCILVLEAALRLNKDLYVHTMRTLDLLAVEPGTVNGETENSTAGLKIRTEEMQCQVCYDLGAAYFQQGSTDSAIYENAREKFFRTKELLAEIGSLSLHCTIDEKRLAGYCQACDVLVPSSDNNSQQLTPYSQVHICLRSGSYQEVVQIFIEDNLTFTLPVQFRQSVLRELFQKAQQGNEALDEICFKICVCNTVRDVLEGRTISVQFNQLFLRPNKEKIDFLLEVCSRSINVEKASDSLKGNMAAFLKNVCLGLEDLQYVFMISSHELFITLLKDEERKLLVDQMRKRSPRVNLCIKPVTSFYDIPASASVNIGQLEHQLILSVDPWRIRQILIELHGMTSERQFWTVSNKWEVPSVYSSVILGIKDNLTRDLVYILMAKGLHCSTVKDFPHSKQLFTACLELVTEFSPKLRQVMLNEMLLLDIRTHEAGVGQSGERPPSDLISRVRGYLEMRLPDIPLRQVVAEECVAFMLNWRENEYLTLQVPAFLFQNNPYVKLGQLLAATCKELPGPKESRRTAKDLWEVVVQICSVSNQHKRGNDGRVSLIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVKLHNVREDIVNDITAEHISIWPSSIPNLQSVDFEAVAITVKELVRYTLSINPNNHAWLIIQADIYFATNQHSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKAIGQTELNASNPEEVLQLAAQRRKKKFLQAMAKLYF
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS8 is required for the recruitment of protein phosphatase 2A (PP2A) to transcription pause-release checkpoint. {ECO:0000250|UniProtKB:Q75QN2}.
uniprot
proteins
mass_dalton
113353
uniprot
proteins
protein_family
Integrator subunit 8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28542170
uniprot
proteins
sequence_length
995
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q75QN2}. Chromosome {ECO:0000250|UniProtKB:Q75QN2}. Note=Associates with chromatin and transcription pause-release checkpoint. {ECO:0000250|UniProtKB:Q75QN2}.
uniprot
proteins