P30557
uniprot
P30557
canonical
amino_acid_sequence
MASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWSDQLER
uniprot
proteins
function
FUNCTION: Receptor for prostaglandin E2 (PGE2) (PubMed:1372606, PubMed:8223569, PubMed:8381413). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS) (PubMed:9751056). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation (PubMed:11535576). Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration (PubMed:10535876). Not required for normal kidney function, normal urine volume and osmolality (PubMed:9843913). {ECO:0000269|PubMed:10535876, ECO:0000269|PubMed:11535576, ECO:0000269|PubMed:1372606, ECO:0000269|PubMed:8223569, ECO:0000269|PubMed:8381413, ECO:0000269|PubMed:9751056, ECO:0000269|PubMed:9843913}.; FUNCTION: [Isoform Alpha]: Receptor for prostaglandin E2 (PGE2); ligand binding activates a signaling cascade via G(i) proteins that leads to inhibition of adenylate cyclase (PubMed:1372606, PubMed:8381413). Shows high agonist-independent constitutive inhibition of adenylate cyclase (PubMed:8223569). {ECO:0000269|PubMed:1372606, ECO:0000269|PubMed:8223569, ECO:0000269|PubMed:8381413}.; FUNCTION: [Isoform Beta]: Receptor for prostaglandin E2 (PGE2); ligand binding activates a signaling cascade via G(i) proteins that leads to inhibition of adenylate cyclase. Requires much higher ligand concentrations than isoform Alpha for activation (PubMed:8381413). Does not display agonist-independent constitutive inhibition of adenylate cyclase (PubMed:8223569). {ECO:0000269|PubMed:8223569, ECO:0000269|PubMed:8381413}.; FUNCTION: [Isoform Gamma]: Receptor for prostaglandin E2 (PGE2); ligand binding can activate several distinct signaling cascades, resulting in activation or inhibition of adenylate cyclase. {ECO:0000269|PubMed:8223569}.
uniprot
proteins
mass_dalton
40077
uniprot
proteins
post_translational_modification
PTM: Ligand binding is affected by cAMP-dependent phosphorylation in brain membranes.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10535876
uniprot
proteins
pubmed
11535576
uniprot
proteins
pubmed
1372606
uniprot
proteins
pubmed
8223569
uniprot
proteins
pubmed
8381413
uniprot
proteins
pubmed
8567630
uniprot
proteins
pubmed
9751056
uniprot
proteins
pubmed
9843913
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1372606, ECO:0000269|PubMed:8223569, ECO:0000269|PubMed:8381413}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..55; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 109..130; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 152..173; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 204..229; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 260..283; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 304..325; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins