Inpp4b
entrez
116699
canonical
uniprot
Q9QWG5
canonical
ensembl
ENSRNOG00000018382
resolver
ensembl
ENSRNOG00055007963
resolver
ensembl
ENSRNOG00060011966
resolver
ensembl
ENSRNOG00065010215
resolver
ensp
ENSRNOP00000024981
resolver
ensp
ENSRNOP00000085379
resolver
enst
ENSRNOT00000097624
resolver
genesymbol
Inpp4b
resolver
uniprot
A0A8I6A1I3
resolver
uniprot
O35825
resolver
uniprot_entry
A0A8I6A1I3_RAT
resolver
uniprot_entry
INP4B_RAT
resolver
uniprot_sec
O35825
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by inositol hexakisphosphate. {ECO:0000269|PubMed:9295334}.
uniprot
proteins
amino_acid_sequence
MEIKEEGTSEEGQHFLPAAQANDPEDIQFTSIQKSPNEPQLEFILACKDLVAPVSDRKLNTVVQVSVIHPVEQTLTRYSSTEIVEGTKDPLFLTGVTFPSDYPIYEETRIKLTVYDVKDKPHDTIRTSVLPEHKDPPPEVARSFLGCASFKVGELLKSKEQLLSLSLRTSDGGKVVGTIEVSLVKMGEIEDGDTDHITTDVQGQKCALVYDSTAPESLSGKENLPFMNAVLRNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQELKELGDLSPHWDNLRNNVLSHCDQMVTMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSSINQLQPLVATHADLLLTSASQHSPDSLRSSLKLLSEKTELFVHAFKDQLVRSALLALYTARPGGILRKPPSPKVSTEEKSSQHDSPQQLRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAKVDKLIERDSRNDKSTGGDSSKDGDADPNLEDSLTSHPREDWYEQLHPLILTLKECMAEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLHDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLRKVAFKITEATSNDVLPVLTGRREHYVVEVKLPATVFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELVQEYYSIFMEKMPPDYISHFQEQNDLKGLLDNLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRRYAFNMLQLMAFPKCYRPPEGTYGKADT
uniprot
proteins
ec_number
3.1.3.66
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate (PubMed:9295334). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (By similarity). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). {ECO:0000250|UniProtKB:O15327, ECO:0000269|PubMed:9295334}.
uniprot
proteins
mass_dalton
105245
uniprot
proteins
pathway_participation
PATHWAY: Signal transduction; phosphatidylinositol signaling pathway. {ECO:0000269|PubMed:9295334}.
uniprot
proteins
protein_family
4-bisphosphate 4-phosphatase family
uniprot
proteins
protein_family
Inositol 3
uniprot
proteins
pubmed
9295334
uniprot
proteins
sequence_length
928
uniprot
proteins