Ak4
entrez
29223
canonical
uniprot
Q9WUS0
canonical
genesymbol
Ak4
resolver
uniprot_entry
KAD4_RAT
resolver
amino_acid_sequence
MASKLLRAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQHWLLDGFPRTLVQAEALDRICDVDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVLGVDDITGEPLVQQEDDKPEALAARLRRYKDAAKPVIELYKSRGVLHQFSGTETNRIWPYVYTLFSNKITPIQSKEAY
uniprot
proteins
ec_number
2.7.4.4
uniprot
proteins
ec_number
2.7.4.6
uniprot
proteins
function
FUNCTION: Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions. Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP. Phosphorylates only AMP when using GTP as phosphate donor. In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor. Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors. Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK. Plays a protective role in the cellular response to oxidative stress. {ECO:0000250|UniProtKB:P27144}.
uniprot
proteins
mass_dalton
25203
uniprot
proteins
protein_family
AK3 subfamily
uniprot
proteins
protein_family
Adenylate kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9813319
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P27144, ECO:0000255|HAMAP-Rule:MF_03170}.
uniprot
proteins