PSMC6
entrez
5706
canonical
uniprot
P62333
canonical
ensembl
ENSG00000100519
resolver
ensp
ENSP00000401802
resolver
ensp
ENSP00000484998
resolver
ensp
ENSP00000677827
resolver
ensp
ENSP00000695302
resolver
enst
ENST00000445930
resolver
enst
ENST00000612399
resolver
genesymbol
PSMC6
resolver
genesymbol_syn
SUG2
resolver
hgnc
HGNC:9553
resolver
uniprot
A0A087X2I1
resolver
uniprot
B2R975
resolver
uniprot
P49719
resolver
uniprot
Q6IBU3
resolver
uniprot
Q92524
resolver
uniprot_entry
A0A087X2I1_HUMAN
resolver
uniprot_entry
PRS10_HUMAN
resolver
uniprot_sec
B2R975
resolver
uniprot_sec
P49719
resolver
uniprot_sec
Q6IBU3
resolver
uniprot_sec
Q92524
resolver
amino_acid_sequence
MADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}.
uniprot
proteins
mass_dalton
44173
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
1317798
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15831487
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
8621709
uniprot
proteins
pubmed
8674546
uniprot
proteins
sequence_length
389
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins