Adgrl1
entrez
65096
canonical
uniprot
O88917
canonical
ensembl
ENSRNOG00000029134
resolver
ensp
ENSRNOP00000043269
resolver
ensp
ENSRNOP00000079689
resolver
ensp
ENSRNOP00000091684
resolver
enst
ENSRNOT00000098082
resolver
enst
ENSRNOT00000115789
resolver
genesymbol
Adgrl1
resolver
genesymbol_syn
Cirl
resolver
genesymbol_syn
Cirl1
resolver
genesymbol_syn
Cl1
resolver
genesymbol_syn
Lphn1
resolver
uniprot
A0A8I6AG63
resolver
uniprot
A0A8I6G3M0
resolver
uniprot
O09026
resolver
uniprot
O35818
resolver
uniprot
O88916
resolver
uniprot_entry
A0A8I6AG63_RAT
resolver
uniprot_entry
A0A8I6G3M0_RAT
resolver
uniprot_entry
AGRL1_RAT
resolver
uniprot_sec
O09026
resolver
uniprot_sec
O35818
resolver
uniprot_sec
O88916
resolver
amino_acid_sequence
MARLAAALWSLCVTTVLVTSATQGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNRTQCVVVAGSDAFPDPCPGTYKYLEVQYDCVPYKVEQKVFVCPGTLQKVLEPTSTHESEHQSGAWCKDPLQAGDRIYVMPWIPYRTDTLTEYASWEDYVAARHTTTYRLPNRVDGTGFVVYDGAVFYNKERTRNIVKYDLRTRIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEGNNGRLVVSQLNPYTLRFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNTNANREEPVSLAFPNPYQFVSSVDYNPRDNQLYVWNNYFVVRYSLEFGPPDPSAGPATSPPLSTTTTARPTPLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATAPAPSTRRPPAPNLHVSPELFCEPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCLPALGLWNPRGPDLSNCTSPWVNQVAQKIKSGENAANIASELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAGKNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDMNATEQVHTATMLLDVLEEGAFLLADNVREPARFLAAKQNVVLEVTVLSTEGQVQELVFPQEYASESSIQLSANTIKQNSRNGVVKVVFILYNNLGLFLSTENATVKLAGEAGTGGPGGASLVVNSQVIAASINKESSRVFLMDPVIFTVAHLEAKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLTNFAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELLFLVGIDKTQYEVACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRVDNYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGAHGSLKTSAMRSNTRYYTGTQVPGQGRHIHQVSLGPRGRSALPESQKDPGGQSGPGDPLTFGLCPSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMGNHLLTNPVLQPRGGTSPYNTLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFPPGDGGPEPPRGRNLADAAAFEKMIISELVHNNLRGASGGAKGPPPEPPVPPVPGVSEDEAGGPGGADRAEIELLYKALEEPLLLPRAQSVLYQSDLDESESCTAEDGATSRPLSSPPGRDSLYASGANLRDSPSYPDSSPEGPNEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGYYQVRRPSHEGYLAAPSLEGPGPDGDGQMQLVTSL
uniprot
proteins
function
FUNCTION: Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. {ECO:0000269|PubMed:9208860, ECO:0000269|PubMed:9830014}.; FUNCTION: [Isoform 2]: Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization.
uniprot
proteins
mass_dalton
166615
uniprot
proteins
mutagenesis
MUTAGEN 802; /note="S->R: Strongly reduced cleavage."; /evidence="ECO:0000269|PubMed:22333914"; MUTAGEN 804; /note="W->I: Abolishes cleavage."; /evidence="ECO:0000269|PubMed:22333914"; MUTAGEN 815; /note="W->S: Abolishes cleavage. Abolishes cell surface localization."; /evidence="ECO:0000269|PubMed:12270923"; MUTAGEN 834; /note="C->S: Strongly reduced cleavage."; /evidence="ECO:0000269|PubMed:12270923, ECO:0000269|PubMed:22333914"; MUTAGEN 834; /note="C->W: Abolishes cleavage. Abolishes cell surface localization."; /evidence="ECO:0000269|PubMed:12270923, ECO:0000269|PubMed:22333914"; MUTAGEN 836; /note="H->S: Abolishes cleavage. No effect on cell surface localization."; /evidence="ECO:0000269|PubMed:22333914"; MUTAGEN 837; /note="L->A: Abolishes cleavage. No effect on cell surface localization."; /evidence="ECO:0000269|PubMed:22333914"; MUTAGEN 838; /note="T->G: Abolishes cleavage. No effect on cell surface localization."; /evidence="ECO:0000269|PubMed:12270923, ECO:0000269|PubMed:22333914"; MUTAGEN 838; /note="T->P: Abolishes cleavage. Abolishes cell surface localization."; /evidence="ECO:0000269|PubMed:12270923, ECO:0000269|PubMed:22333914"; MUTAGEN 840; /note="F->A: Strongly reduced cleavage."; /evidence="ECO:0000269|PubMed:22333914
uniprot
proteins
post_translational_modification
PTM: Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus. {ECO:0000269|PubMed:9208860}.
uniprot
proteins
protein_family
Adhesion G protein-coupled receptor (ADGR) subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
10958799
uniprot
proteins
pubmed
12270923
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
21724987
uniprot
proteins
pubmed
22333914
uniprot
proteins
pubmed
8798521
uniprot
proteins
pubmed
9208860
uniprot
proteins
pubmed
9261169
uniprot
proteins
pubmed
9830014
uniprot
proteins
pubmed
9920906
uniprot
proteins
sequence_length
1515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21724987, ECO:0000269|PubMed:22333914}; Multi-pass membrane protein {ECO:0000269|PubMed:21724987, ECO:0000269|PubMed:22333914}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane. Cell projection, axon. Cell projection, growth cone. Synapse. Presynaptic cell membrane. Synapse, synaptosome. Note=Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts.
uniprot
proteins
transmembrane_region
TRANSMEM 858..878; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 893..913; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 920..940; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 965..985; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 1002..1022; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 1050..1070; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 1075..1095; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins