Creb3l3
entrez
314638
canonical
uniprot
Q5FVM5
canonical
ensembl
ENSRNOG00000032202
resolver
ensp
ENSRNOP00000044840
resolver
enst
ENSRNOT00000044484
resolver
genesymbol
Creb3l3
resolver
uniprot_entry
CR3L3_RAT
resolver
amino_acid_sequence
MDGDISTGKMASPACAMAPLDSMEVLDLLFDGQDGILRNVDLAESWILTREEQKVLPNSDSDEFLNSILGPGDSDPSSPIWSPADSDSGISEDLPSDSQDTPPGSGPGSANVAARCHPSKQGEGPCPSYLPSTACPEPPRTQVHESSVAIDLDMWSTDTLYPEEQAGSPSRFNLTVKELLLSGGGGDLQQHPLAASQLLGPGSGHCQELVLTEDEKKLLAKEGVTLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLENRMSACTAQNQELQRKVLHLEKQNLSLLEQLKHLQALVVQSTSKPAHAGTCIAVLLLSFVLIILPSISPFTANKVDSPGDFIPVRVFSRTLHNHAASRVAPDVTPGPEVPGPHKGSSGGLSADWGNFLEIPMLDDPTEELDNTTLVLANSTEDLGRATLLDWVASEPLLGQMGLEIPGEEIWLSWVPRWLRVRVVQDALGVL
uniprot
proteins
function
FUNCTION: Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. Binds the cAMP response element (CRE). Activates transcription through box-B element and CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes (By similarity). May be involved in growth suppression. Regulates FGF21 transcription (By similarity). Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q91XE9, ECO:0000269|PubMed:15800215}.
uniprot
proteins
mass_dalton
50862
uniprot
proteins
post_translational_modification
PTM: Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2) (By similarity). {ECO:0000250}.; PTM: N-glycosylation is required for optimal proteolytic activation. {ECO:0000250}.; PTM: Ubiquitinated at Lys-290 by SYNV1/HRD1 via 'Lys-27'-linked ubiquitin. {ECO:0000250|UniProtKB:Q68CJ9}.
uniprot
proteins
protein_family
ATF subfamily
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15800215
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q68CJ9}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q68CJ9}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 3]: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
uniprot
proteins
transmembrane_region
TRANSMEM 320..340; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins