TRIM65
entrez
201292
canonical
uniprot
Q6PJ69
canonical
ensembl
ENSG00000141569
resolver
ensp
ENSP00000269383
resolver
ensp
ENSP00000444607
resolver
ensp
ENSP00000594769
resolver
ensp
ENSP00000594770
resolver
ensp
ENSP00000616179
resolver
ensp
ENSP00000616181
resolver
ensp
ENSP00000657027
resolver
ensp
ENSP00000714778
resolver
enst
ENST00000269383
resolver
genesymbol
TRIM65
resolver
hgnc
HGNC:27316
resolver
uniprot
Q4G0F0
resolver
uniprot
Q6DKJ6
resolver
uniprot
Q9BRP6
resolver
uniprot_entry
TRI65_HUMAN
resolver
uniprot_sec
Q4G0F0
resolver
uniprot_sec
Q6DKJ6
resolver
uniprot_sec
Q9BRP6
resolver
amino_acid_sequence
MAAQLLEEKLTCAICLGLYQDPVTLPCGHNFCGACIRDWWDRCGKACPECREPFPDGAELRRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGRCVCSVCTVRECRLHERALLDAERLKREAQLRASLEVTQQQATQAEGQLLELRKQSSQIQNSACILASWVSGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEEQRLRVHLEAVARHGCRIRELLEQVDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDLKQLLSRLCGLLLEEGSHPGAPAKPVDLAPVEAPGPLAPVPSTVCPLRRKLWQNYRNLTFDPVSANRHFYLSRQDQQVKHCRQSRGPGGPGSFELWQVQCAQSFQAGHHYWEVRASDHSVTLGVSYPQLPRCRLGPHTDNIGRGPCSWGLCVQEDSLQAWHNGEAQRLPGVSGRLLGMDLDLASGCLTFYSLEPQTQPLYTFHALFNQPLTPVFWLLEGRTLTLCHQPGAVFPLGPQEEVLS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays a role in several processes including innate immnity, autophagy or inflammation (PubMed:28594402, PubMed:34512673). Negatively regulates miRNAs by modulating the ubiquitination and stability of TNRC6A, a protein involved in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (PubMed:24778252). This ubiquitination results in the suppressed expression of miR-138-5p leading to increased autophagy (PubMed:31160576). Upon enteroviral infection, promotes 'Lys-63'-mediated ubiquitination activation of IFIH1/MDA5 leading to innate signaling cascade (PubMed:28594402). Mechanistically, selectively recognizes MDA5 filaments that occur on dsRNAs (PubMed:33373584). Plays also a role in limitation of inflammation through different mechanisms. First, promotes 'Lys-48'-mediated ubiquitination of VCAM1 leading to its degradation and limitation of LPS-induced lung inflammation (PubMed:31310649). In addition, negatively regulates inflammasome activation by promoting 'lys48'-linked ubiquitination of NLRP3 which is critical for the inhibition of NLRP3 inflammasome activation in resting macrophages (PubMed:34512673). {ECO:0000269|PubMed:24778252, ECO:0000269|PubMed:28594402, ECO:0000269|PubMed:31160576, ECO:0000269|PubMed:31310649, ECO:0000269|PubMed:33373584, ECO:0000269|PubMed:34512673}.
uniprot
proteins
mass_dalton
57353
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
24778252
uniprot
proteins
pubmed
28084320
uniprot
proteins
pubmed
28594402
uniprot
proteins
pubmed
31160576
uniprot
proteins
pubmed
31310649
uniprot
proteins
pubmed
33373584
uniprot
proteins
pubmed
34512673
uniprot
proteins
sequence_length
517
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24778252, ECO:0000269|PubMed:34512673}.
uniprot
proteins