Trim17
entrez
64702
canonical
uniprot
Q9WV59
canonical
ensembl
ENSRNOG00000022983
resolver
ensembl
ENSRNOG00055029889
resolver
ensembl
ENSRNOG00060031045
resolver
ensembl
ENSRNOG00065008261
resolver
ensp
ENSRNOP00000003885
resolver
ensp
ENSRNOP00055042731
resolver
ensp
ENSRNOP00060044706
resolver
ensp
ENSRNOP00065009688
resolver
enst
ENSRNOT00000003885
resolver
enst
ENSRNOT00055051794
resolver
enst
ENSRNOT00060053900
resolver
enst
ENSRNOT00065013108
resolver
genesymbol
Trim17
resolver
genesymbol_syn
Terf
resolver
uniprot_entry
TRI17_RAT
resolver
amino_acid_sequence
MDAVELARRLQEEATCSICLDYFTDPVMTACGHNFCRECIQMSWEKGKGKKGKKKQKGSFPCPECREMSPQRNLRPNRLLTKVAEMARQHPGLHKRDLCQIHQEPLKLFCQDDQTPICVVCREAQEHRMHRVLPLDEAAREYKLRLEEDIKYLREEMMKTETLQAKEEQTLTEWQERVKERRERILEEFQKVVLFLVEEERRLLQILKKEEDDTLGKLQDSKASLDHQSRSLDLILLQLEEQTQQEPLQMLQDVKDTLTRKESLSMQYPEVVLPVAIKTVCRVPGQIEVLKSFQEDVVPDPSTAYPYLLLYESRQRRYLSPPPEGSAPYSKDRFLAYPCAVGQKSFSSGRHYWEVGMNLTGDALWALGVCRDNVSRKDRVLKSPENGFWVVQLSKGKKHLPLLPNSIPVTLTEPPSHMGIFLDFQAGEVSFYSVNDGSHLHSFSQVAFPGPLLPFFCLGSPKSGQMVISTVTMWVKG
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation. Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation. Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies. Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1 (By similarity). Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death. In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities. Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells (By similarity). Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1 (By similarity). {ECO:0000250|UniProtKB:Q7TPM3, ECO:0000250|UniProtKB:Q9Y577}.
uniprot
proteins
mass_dalton
54954
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000250|UniProtKB:Q9Y577}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9792805
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y577}. Lysosome {ECO:0000250|UniProtKB:Q9Y577}.
uniprot
proteins