Skap1
entrez
78473
canonical
uniprot
Q3UUV5
canonical
ensembl
ENSMUSG00000057058
resolver
ensp
ENSMUSP00000071445
resolver
ensp
ENSMUSP00000098090
resolver
ensp
ENSMUSP00000099443
resolver
genesymbol
Skap1
resolver
genesymbol_syn
Scap1
resolver
uniprot
B2RWZ1
resolver
uniprot
Q3TE54
resolver
uniprot
Q3UUT7
resolver
uniprot
Q3UUX6
resolver
uniprot
Q3V3I1
resolver
uniprot_entry
B2RWZ1_MOUSE
resolver
uniprot_entry
Q3V3I1_MOUSE
resolver
uniprot_entry
SKAP1_MOUSE
resolver
uniprot_sec
Q3TE54
resolver
uniprot_sec
Q3UUT7
resolver
uniprot_sec
Q3UUX6
resolver
amino_acid_sequence
MQAVALPEEICWLLEDTEDFLAEGLQNENLSPGAQDQRAHILRGFQQIKSRYCWDFQPQGGDLGQDGSDDNLSGTHGPPLTSEASFWSDYQDEGIEDILRGAQELDSVIKQGYLEKKSKDHSFFGSEWQKRWCVISRGLFLYYANEKSKQPKGTFLIKGYSVRMAPHLRKDSKKESCFELISQDRRSYEFTASSPAEARDWVDQISFLLKDLSSLTIPFEEEEEEEEEEEKEEEEMYNDVDGFDSPRSGSQCRAMALPEPTEKEEDIYEVLPDDDDLEEDTCGAHRRRVDYADYYQGLWDCHGDQPDELSFQRGDLIRILSKEYNMYGWWVGELNSVIGIVPKDYLTTAFEMEGI
uniprot
proteins
function
FUNCTION: Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway (By similarity). Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (PubMed:12681493). {ECO:0000250|UniProtKB:Q86WV1, ECO:0000269|PubMed:12681493}.
uniprot
proteins
mass_dalton
40962
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-268 is required for GRB2 interaction (By similarity). Phosphorylation by FYN on Tyr-291 abolishes interaction with FYB1. Tyr-237 is dephosphorylated by PTPRC (By similarity). {ECO:0000250|UniProtKB:Q86WV1}.
uniprot
proteins
protein_family
SKAP family
uniprot
proteins
pubmed
12681493
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17947660
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86WV1}. Nucleus {ECO:0000250|UniProtKB:Q86WV1}. Cell membrane {ECO:0000250|UniProtKB:Q86WV1}. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane. {ECO:0000250|UniProtKB:Q86WV1}.
uniprot
proteins