Fbxw24
entrez
382106
canonical
uniprot
E9PXM9
canonical
ensembl
ENSMUSG00000062275
resolver
ensp
ENSMUSP00000073617
resolver
enst
ENSMUST00000073962
resolver
genesymbol
Fbxw24
resolver
genesymbol_syn
EG382106
resolver
uniprot
Q66JY5
resolver
uniprot_entry
E9PXM9_MOUSE
resolver
uniprot_entry
Q66JY5_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: In oocytes and preimplantation embryos, SCF(Fbxw24) ubiquitin ligase complex is maintained inactive by cytoplasmic lattices. {ECO:0000269|PubMed:41845018}.
uniprot
proteins
amino_acid_sequence
MEIHLSSFPMMEIFSYLDAYSLLQVAQVNKNWNALASNDFLWRKLCQERWLFCDMVTLQLLGKETWKQFFVYRTWQEHVKSRAIPEDFTYKEIPLECGVRGYAGYISGCALTRNGQGKSVVCMVSSKNKISTWDISESVITWVSPVQPASIKLLTTLPDMHIAVTVDIQSTIKLWDCHNREALATNNLESPCKSLKAVISKDGPIVLAGDILGNLYIFRIPDLHLISTVNVFPCGFDKIDCSPQKKWVLLSQNHPCIYPKVFYMSSLLRTSEFSDPVSTVLEFSLCKRAFWTPRREDRITLMSRRGRPIVTRFETFDMKLEENGNKTIVKGDLVASFSLQDYNENPKWMGVSDKSVIVCSTGSSLLLFSMKGLHLQTFQYSPEMIVRLWVDPVHVIITCNDGSIDVYMWEERSLLLKMCYRLQNGRHLPPFGFIKNLLCDDVSIVQLMIDRQGPCFLMAYTLNICS
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, which mediates ubiquitination and degradation of target proteins (PubMed:35858239). Acts as a regulator of female fertility by mediating ubiquitination and degradation of specific proteins during meiosis, such as SYCP3, a key component of the synaptonemal complex that holds homologous chromosomes together (PubMed:35858239). {ECO:0000269|PubMed:35858239}.
uniprot
proteins
mass_dalton
53411
uniprot
proteins
mutagenesis
MUTAGEN 304..307; /note="RRGR->AAGA: Decreased ability to promote ubiquitination of SYCP3, when associated with 417-A--A-421."; /evidence="ECO:0000269|PubMed:35858239"; MUTAGEN 417..421; /note="KMCYR->AMCYA: Decreased ability to promote ubiquitination of SYCP3, when associated with 304-A--A-307."; /evidence="ECO:0000269|PubMed:35858239
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:35858239}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21162934
uniprot
proteins
pubmed
35858239
uniprot
proteins
pubmed
41845018
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35858239}.
uniprot
proteins