PTK7
entrez
5754
canonical
uniprot
Q13308
canonical
ensembl
ENSG00000112655
resolver
ensp
ENSP00000230419
resolver
ensp
ENSP00000325462
resolver
ensp
ENSP00000325992
resolver
ensp
ENSP00000326029
resolver
ensp
ENSP00000418754
resolver
genesymbol
PTK7
resolver
genesymbol_syn
CCK4
resolver
hgnc
HGNC:9618
resolver
uniprot
A8K974
resolver
uniprot
B7Z477
resolver
uniprot
E9PFZ5
resolver
uniprot
Q13417
resolver
uniprot
Q5T650
resolver
uniprot
Q6IQ54
resolver
uniprot
Q8NFA5
resolver
uniprot
Q8NFA6
resolver
uniprot
Q8NFA7
resolver
uniprot
Q8NFA8
resolver
uniprot_entry
PTK7_HUMAN
resolver
uniprot_sec
A8K974
resolver
uniprot_sec
B7Z477
resolver
uniprot_sec
E9PFZ5
resolver
uniprot_sec
Q13417
resolver
uniprot_sec
Q5T650
resolver
uniprot_sec
Q6IQ54
resolver
uniprot_sec
Q8NFA5
resolver
uniprot_sec
Q8NFA6
resolver
uniprot_sec
Q8NFA7
resolver
uniprot_sec
Q8NFA8
resolver
amino_acid_sequence
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP
uniprot
proteins
function
FUNCTION: Inactive tyrosine kinase involved in the Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathways. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. Does not bind ATP (PubMed:24107129, PubMed:32619402). {ECO:0000269|PubMed:18471990, ECO:0000269|PubMed:20558616, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:21103379, ECO:0000269|PubMed:21132015, ECO:0000269|PubMed:24107129, ECO:0000269|PubMed:32619402}.
uniprot
proteins
mass_dalton
118392
uniprot
proteins
mutagenesis
MUTAGEN 622; /note="L->D: Prevents proteolysis by MMP14."; /evidence="ECO:0000269|PubMed:20837484"; MUTAGEN 641; /note="M->R: No impact on proteolysis by MMP14."; /evidence="ECO:0000269|PubMed:20837484"; MUTAGEN 701; /note="M->D: No impact on proteolysis by MMP14."; /evidence="ECO:0000269|PubMed:20837484
uniprot
proteins
post_translational_modification
PTM: MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway. {ECO:0000269|PubMed:20837484}.
uniprot
proteins
protein_family
Insulin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
12427550
uniprot
proteins
pubmed
12754519
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18471990
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
20558616
uniprot
proteins
pubmed
20837484
uniprot
proteins
pubmed
21103379
uniprot
proteins
pubmed
21132015
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24107129
uniprot
proteins
pubmed
32619402
uniprot
proteins
pubmed
7478540
uniprot
proteins
pubmed
8882711
uniprot
proteins
sequence_length
1070
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20837484}; Single-pass type I membrane protein {ECO:0000255}. Cell junction {ECO:0000269|PubMed:20837484}. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells. {ECO:0000269|PubMed:20837484}.
uniprot
proteins
transmembrane_region
TRANSMEM 705..725; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins