Septin4
entrez
18952
canonical
uniprot
P28661
canonical
ensembl
ENSMUSG00000020486
resolver
ensp
ENSMUSP00000018544
resolver
ensp
ENSMUSP00000060127
resolver
ensp
ENSMUSP00000103594
resolver
ensp
ENSMUSP00000103596
resolver
ensp
ENSMUSP00000112960
resolver
ensp
ENSMUSP00000158869
resolver
enst
ENSMUST00000239011
resolver
genesymbol
Septin4
resolver
genesymbol_syn
Bh5
resolver
genesymbol_syn
Gm11492
resolver
genesymbol_syn
Pnutl2
resolver
genesymbol_syn
Sep4
resolver
genesymbol_syn
Sept4
resolver
uniprot
A0A5F8MP96
resolver
uniprot
B2KGM3
resolver
uniprot
B2KGM6
resolver
uniprot
Q3UVH1
resolver
uniprot
Q3UZC3
resolver
uniprot
Q5ND10
resolver
uniprot
Q5ND15
resolver
uniprot
Q5ND16
resolver
uniprot
Q5ND19
resolver
uniprot
Q7TPM7
resolver
uniprot
Q80VX1
resolver
uniprot_entry
A0A5F8MP96_MOUSE
resolver
uniprot_entry
SEPT4_MOUSE
resolver
uniprot_sec
B2KGM3
resolver
uniprot_sec
B2KGM6
resolver
uniprot_sec
Q3UVH1
resolver
uniprot_sec
Q3UZC3
resolver
uniprot_sec
Q5ND10
resolver
uniprot_sec
Q5ND15
resolver
uniprot_sec
Q5ND16
resolver
uniprot_sec
Q5ND19
resolver
uniprot_sec
Q7TPM7
resolver
uniprot_sec
Q80VX1
resolver
amino_acid_sequence
MDHSLGWQGNSVPEDGTEAGIKHFLEDSSDDAELSKFVKDFPGSEPYHSAESKTRVARPQILEPRPQSPDLCDDDVEFRGSLWPQPSDSQQYFSAPAPLSPSSRPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDRKKCKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQRQMKETH
uniprot
proteins
function
FUNCTION: Filament-forming cytoskeletal GTPase (Probable). Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP (PubMed:30389919). May also play a role in the regulation of cell fate in the intestine (PubMed:30389919). Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis; via its interaction with XIAP (PubMed:20952537). Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP (PubMed:23788729). Plays an important role in male fertility and sperm motility (PubMed:15737930, PubMed:15737931). During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (PubMed:15737930, PubMed:15737931). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (PubMed:20181826). Required for dopaminergic metabolism in presynaptic autoreceptors; potentially via activity as a presynaptic scaffold protein (PubMed:17296554). {ECO:0000269|PubMed:15737930, ECO:0000269|PubMed:15737931, ECO:0000269|PubMed:17296554, ECO:0000269|PubMed:20181826, ECO:0000269|PubMed:20952537, ECO:0000269|PubMed:23788729, ECO:0000269|PubMed:30389919, ECO:0000305}.
uniprot
proteins
mass_dalton
54936
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by DYRK1A. {ECO:0000269|PubMed:18938227}.; PTM: Ubiquitinated by AREL1. {ECO:0000250|UniProtKB:O43236}.; PTM: [Isoform 4]: May be phosphorylated. {ECO:0000269|PubMed:12581152}.
uniprot
proteins
protein_family
Septin GTPase family
uniprot
proteins
protein_family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily
uniprot
proteins
pubmed
12106288
uniprot
proteins
pubmed
12581152
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15737930
uniprot
proteins
pubmed
15737931
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17296554
uniprot
proteins
pubmed
17546647
uniprot
proteins
pubmed
18938227
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20181826
uniprot
proteins
pubmed
20952537
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21679490
uniprot
proteins
pubmed
23479728
uniprot
proteins
pubmed
23788729
uniprot
proteins
pubmed
27811987
uniprot
proteins
pubmed
28346465
uniprot
proteins
pubmed
30389919
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17546647, ECO:0000269|PubMed:20181826}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:15737930, ECO:0000269|PubMed:15737931, ECO:0000269|PubMed:27811987}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:O43236}. Cell projection, axon {ECO:0000269|PubMed:17296554, ECO:0000269|PubMed:20181826}. Cell projection, dendrite {ECO:0000269|PubMed:20181826}. Perikaryon {ECO:0000269|PubMed:20181826}. Synapse {ECO:0000250|UniProtKB:O43236}. Note=Found in the sperm annulus, a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum (PubMed:15737930, PubMed:15737931, PubMed:27811987). In platelets, found in areas surrounding alpha-granules (By similarity). Expressed and colocalized with SLC6A3 and SNCA in axon terminals, especially at the varicosities (PubMed:17296554). {ECO:0000250|UniProtKB:O43236, ECO:0000269|PubMed:15737930, ECO:0000269|PubMed:15737931, ECO:0000269|PubMed:17296554, ECO:0000269|PubMed:27811987}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:12581152}.; SUBCELLULAR LOCATION: [Isoform 4]: Mitochondrion {ECO:0000269|PubMed:12581152}. Cytoplasm, cytosol {ECO:0000269|PubMed:12581152}. Note=In retinoic acid-treated P19 cells, found first in the mitochondria and at later times, as neuronal differentiation proceeds, in the cytosol. Expressed at the annulus in spermatozoa (PubMed:28346465). {ECO:0000269|PubMed:12581152, ECO:0000269|PubMed:28346465}.
uniprot
proteins