Lrat
entrez
79235
canonical
uniprot
Q9JI60
canonical
ensembl
ENSMUSG00000028003
resolver
ensp
ENSMUSP00000029632
resolver
enst
ENSMUST00000029632
resolver
genesymbol
Lrat
resolver
uniprot
B2RUR5
resolver
uniprot_entry
B2RUR5_MOUSE
resolver
uniprot_entry
LRAT_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by all-trans-retinyl alpha-bromoacetate and N-boc-L-biocytinyl-11-aminoundecane chloro-methyl ketone (BACMK). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MKNPMLEAASLLLEKLLLISNFKLFSVSVPGGGTGKNRPYEISSFVRGDVLEVSRTHFIHYGIYLGENRVAHLMPDILLALTNDKERTQKVVSNKRLLLGVICKVASIRVDTVEDFAYGADILVNHLDGTLKKKSLLNEEVARRAEQQLGLTPYSLLWNNCEHFVTYCRYGSRISPQAEKFYDTVKIIIRDQRSSLASAVLGLASIVYTGLASYMTLPAICIPFCLWMMSG
uniprot
proteins
ec_number
2.3.1.135
uniprot
proteins
function
FUNCTION: Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A (PubMed:28758396). LRAT plays a critical role in vision (By similarity). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (By similarity). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (PubMed:25416279). {ECO:0000250|UniProtKB:O95237, ECO:0000269|PubMed:25416279, ECO:0000269|PubMed:28758396}.
uniprot
proteins
mass_dalton
25820
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="E->L: Increases degradation via the proteasomal pathway. No effect on endoplasmic reticulum location. Impairs vitamin A uptake. No effect on retinol acyltransferase activity."; /evidence="ECO:0000269|PubMed:28758396
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism.
uniprot
proteins
protein_family
H-rev107 family
uniprot
proteins
pubmed
11108736
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17114808
uniprot
proteins
pubmed
18544127
uniprot
proteins
pubmed
20628054
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25416279
uniprot
proteins
pubmed
28758396
uniprot
proteins
sequence_length
231
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17114808, ECO:0000269|PubMed:28758396}; Single-pass membrane protein {ECO:0000269|PubMed:17114808}. Rough endoplasmic reticulum {ECO:0000250}. Endosome, multivesicular body {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 195..215; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins