HP
entrez
3240
canonical
uniprot
P00738
canonical
ensembl
ENSG00000257017
resolver
ensp
ENSP00000348170
resolver
ensp
ENSP00000381199
resolver
ensp
ENSP00000454966
resolver
enst
ENST00000565574
resolver
genesymbol
HP
resolver
hgnc
HGNC:5141
resolver
uniprot
A0A0C4DGL8
resolver
uniprot
B0AZL5
resolver
uniprot
P00737
resolver
uniprot
Q0VAC4
resolver
uniprot
Q0VAC5
resolver
uniprot
Q2PP15
resolver
uniprot
Q3B7J0
resolver
uniprot
Q6LBY9
resolver
uniprot
Q6PEJ8
resolver
uniprot
Q9UC67
resolver
uniprot_entry
A0A0C4DGL8_HUMAN
resolver
uniprot_entry
HPT_HUMAN
resolver
uniprot_entry
Q6PEJ8_HUMAN
resolver
uniprot_sec
B0AZL5
resolver
uniprot_sec
P00737
resolver
uniprot_sec
Q0VAC4
resolver
uniprot_sec
Q0VAC5
resolver
uniprot_sec
Q2PP15
resolver
uniprot_sec
Q3B7J0
resolver
uniprot_sec
Q6LBY9
resolver
uniprot_sec
Q9UC67
resolver
amino_acid_sequence
MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN
uniprot
proteins
disease_involvement
DISEASE: Anhaptoglobinemia (AHP) [MIM:614081]: A condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Congenital haptoglobin deficiency is a risk factor for anaphylactic non-hemolytic transfusion reactions. {ECO:0000269|PubMed:14999562}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. {ECO:0000269|PubMed:21248165}.; FUNCTION: The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. {ECO:0000269|PubMed:21248165}.
uniprot
proteins
mass_dalton
45205
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
12754519
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14760718
uniprot
proteins
pubmed
1478675
uniprot
proteins
pubmed
14999562
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16740002
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19659435
uniprot
proteins
pubmed
19805376
uniprot
proteins
pubmed
19838169
uniprot
proteins
pubmed
21248165
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2987228
uniprot
proteins
pubmed
31142615
uniprot
proteins
pubmed
3519135
uniprot
proteins
pubmed
4018023
uniprot
proteins
pubmed
4573324
uniprot
proteins
pubmed
6310515
uniprot
proteins
pubmed
6310599
uniprot
proteins
pubmed
6325933
uniprot
proteins
pubmed
6330675
uniprot
proteins
pubmed
6546723
uniprot
proteins
pubmed
6688992
uniprot
proteins
pubmed
6997877
uniprot
proteins
pubmed
7637327
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins