Actb
entrez
11461
canonical
uniprot
P60710
canonical
ensembl
ENSMUSG00000029580
resolver
ensp
ENSMUSP00000098066
resolver
enst
ENSMUST00000100497
resolver
genesymbol
Actb
resolver
uniprot
B2RRX1
resolver
uniprot
P02570
resolver
uniprot
P70514
resolver
uniprot
P99021
resolver
uniprot
Q11211
resolver
uniprot
Q3TI89
resolver
uniprot
Q3TVP6
resolver
uniprot
Q64316
resolver
uniprot
Q6ZWM3
resolver
uniprot_entry
ACTB_MOUSE
resolver
uniprot_entry
B2RRX1_MOUSE
resolver
uniprot_sec
P02570
resolver
uniprot_sec
P70514
resolver
uniprot_sec
P99021
resolver
uniprot_sec
Q11211
resolver
uniprot_sec
Q3TI89
resolver
uniprot_sec
Q3TVP6
resolver
uniprot_sec
Q64316
resolver
uniprot_sec
Q6ZWM3
resolver
amino_acid_sequence
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (By similarity). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (By similarity). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:23558171, PubMed:25759381). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (By similarity). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:P60709, ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:23558171, ECO:0000269|PubMed:25759381}.
uniprot
proteins
mass_dalton
41737
uniprot
proteins
post_translational_modification
PTM: ISGylated. {ECO:0000269|PubMed:16139798}.; PTM: Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization (PubMed:23911929). MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (PubMed:23911929). {ECO:0000269|PubMed:23911929}.; PTM: Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. {ECO:0000250|UniProtKB:P60709}.; PTM: Methylated at His-73 by SETD3 (PubMed:30626964). Methylation at His-73 is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). {ECO:0000269|PubMed:30626964}.; PTM: [Actin, cytoplasmic 1]: N-terminal cleavage of acetylated methionine of immature cytoplasmic actin by ACTMAP. {ECO:0000250|UniProtKB:P60709}.; PTM: [Actin, cytoplasmic 1, N-terminally processed]: N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. In contrast, filament nucleation by the Arp2/3 complex is not affected. {ECO:0000250|UniProtKB:P60709}.
uniprot
proteins
protein_family
Actin family
uniprot
proteins
pubmed
12522145
uniprot
proteins
pubmed
16139798
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21128978
uniprot
proteins
pubmed
213279
uniprot
proteins
pubmed
21969592
uniprot
proteins
pubmed
23558171
uniprot
proteins
pubmed
23911929
uniprot
proteins
pubmed
24806444
uniprot
proteins
pubmed
25759381
uniprot
proteins
pubmed
30626964
uniprot
proteins
pubmed
30659401
uniprot
proteins
pubmed
3084797
uniprot
proteins
pubmed
31605441
uniprot
proteins
pubmed
3754329
uniprot
proteins
pubmed
37952086
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Nucleus {ECO:0000269|PubMed:23558171, ECO:0000269|PubMed:25759381}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250|UniProtKB:P60709}.
uniprot
proteins