P0DN77
uniprot
P0DN77
canonical
amino_acid_sequence
MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA
uniprot
proteins
function
FUNCTION: G protein-coupled photoreceptor that selectively activates transducin G alpha protein (G(t)) in response to medium-wavelength (green) light, thereby stimulating the G(t)/transducin protein pathway (By similarity). This activation leads to increased cGMP phosphodiesterase activity, resulting in decreased intracellular cGMP and subsequent closure of cGMP-gated ion channels. The process is initiated when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers the G protein-mediated phototransduction cascade (By similarity). Mediates visual perception of green light in cone photoreceptor cells (By similarity). {ECO:0000250|UniProtKB:P04000, ECO:0000250|UniProtKB:P04001}.
uniprot
proteins
mass_dalton
40584
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. O-glycosylated. {ECO:0000250|UniProtKB:P04001}.; PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. {ECO:0000250|UniProtKB:P04001}.; PTM: Contains one retinal chromophore covalently bound to a lysine residue via a Schiff base. Upon light absorption, the bound 11-cis-retinal isomerizes to all-trans-retinal. Following activation, the covalently bound all-trans-retinal is released through hydrolysis of the Schiff base, and OPN1 is regenerated by binding a new 11-cis-retinal molecule. {ECO:0000250|UniProtKB:P04001}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Opsin subfamily
uniprot
proteins
pubmed
15772651
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P04001}; Multi-pass membrane protein {ECO:0000255}. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:O35599}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 53..77; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 90..115; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 130..149; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 169..192; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 219..246; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 269..292; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 301..325; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins