Rnls
entrez
361751
canonical
uniprot
Q5U2W9
canonical
ensembl
ENSRNOG00000020705
resolver
ensp
ENSRNOP00000028098
resolver
ensp
ENSRNOP00000105868
resolver
enst
ENSRNOT00000028098
resolver
genesymbol
Rnls
resolver
uniprot_entry
RNLS_RAT
resolver
amino_acid_sequence
MFRVLVVGAGLTGSLCAALLRKEITAPLYLALWDKAGDIGGRMTTANSPHNPRCTADLGAQYITCTPHYAKKHQNFYEELLAHGILEPLTSPIKGMEVKEGESNFVAPHGVSSIIKYYLKESGAEVFLRQCVTQINLRDNKWEVSEDTGSTQQFDLVILTMPAPQILGLQGDIVNLISERQRQQLASVSYSSRYALGLFYEAGMKIDVPWAGQYITSNPCIRFISIDSKKRNTESSECGPLLVVHTTVPFGVTHLEHSEEDVQELITQQLETILPGLPPPVATKCWKWRYSQVTNSAANSPGQMTLHLNPFLIYI
uniprot
proteins
ec_number
1.6.3.5
uniprot
proteins
function
FUNCTION: Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+) (By similarity). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. {ECO:0000250|UniProtKB:Q5VYX0, ECO:0000269|PubMed:15841207, ECO:0000269|PubMed:18299506}.
uniprot
proteins
mass_dalton
34951
uniprot
proteins
protein_family
Renalase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15841207
uniprot
proteins
pubmed
18299506
uniprot
proteins
sequence_length
315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins