NLGN4X
entrez
57502
canonical
uniprot
Q8N0W4
canonical
ensembl
ENSG00000146938
resolver
ensp
ENSP00000275857
resolver
ensp
ENSP00000370482
resolver
ensp
ENSP00000370483
resolver
ensp
ENSP00000370485
resolver
ensp
ENSP00000439203
resolver
ensp
ENSP00000569769
resolver
ensp
ENSP00000569770
resolver
ensp
ENSP00000569771
resolver
ensp
ENSP00000569773
resolver
genesymbol
NLGN4X
resolver
genesymbol_syn
KIAA1260
resolver
genesymbol_syn
NLGN4
resolver
hgnc
HGNC:14287
resolver
uniprot
A8K4S1
resolver
uniprot
B3KP11
resolver
uniprot
Q6UX10
resolver
uniprot
Q9ULG0
resolver
uniprot_entry
A8K4S1_HUMAN
resolver
uniprot_entry
B3KP11_HUMAN
resolver
uniprot_entry
NLGNX_HUMAN
resolver
uniprot_sec
Q6UX10
resolver
uniprot_sec
Q9ULG0
resolver
amino_acid_sequence
MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQRNTTNDIAHIQNEEIMSLQMKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPLMTPNTITMIPNTLTGMQPLHTFNTFSGGQNSTNLPHGHSTTRV
uniprot
proteins
disease_involvement
DISEASE: Autism, X-linked 2 (AUTSX2) [MIM:300495]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate intellectual disability. {ECO:0000269|PubMed:14963808}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. {ECO:0000269|PubMed:18093521}.
uniprot
proteins
mass_dalton
91915
uniprot
proteins
mutagenesis
MUTAGEN 102; /note="N->A: N-glycosylation, localization to synapses, dendrites, and the cell membrane, as well as availability for trans-synaptic adhesion, are all impaired; when associated with A-511."; /evidence="ECO:0000269|PubMed:37865312"; MUTAGEN 511; /note="N->A: N-glycosylation, localization to synapses, dendrites, and the cell membrane, as well as availability for trans-synaptic adhesion, are all impaired; when associated with A-102."; /evidence="ECO:0000269|PubMed:37865312
uniprot
proteins
post_translational_modification
PTM: N-glycosylated, contains high-mannose, hybrid, complex and sialylated N-glycans. N-glycosylation is essential for localization to synapses, dendrites, and the cell membrane, and enhances its availability for trans-synaptic adhesion. O-glycosylated. {ECO:0000269|PubMed:37865312}.
uniprot
proteins
protein_family
Type-B carboxylesterase/lipase family
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
11368788
uniprot
proteins
pubmed
12669065
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14963808
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18093521
uniprot
proteins
pubmed
37865312
uniprot
proteins
pubmed
9278515
uniprot
proteins
sequence_length
816
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37865312}; Single-pass type I membrane protein {ECO:0000255}. Postsynaptic density membrane {ECO:0000250|UniProtKB:B0F2B4}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:B0F2B4}. Cell projection, dendrite {ECO:0000269|PubMed:37865312}. Synapse {ECO:0000269|PubMed:37865312}. Note=Localizes to dendritic membrane. {ECO:0000269|PubMed:37865312}.
uniprot
proteins
transmembrane_region
TRANSMEM 677..697; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins