GRM8
entrez
2918
canonical
uniprot
O00222
canonical
ensembl
ENSG00000179603
resolver
ensp
ENSP00000344173
resolver
ensp
ENSP00000351142
resolver
ensp
ENSP00000516623
resolver
ensp
ENSP00000516624
resolver
ensp
ENSP00000516625
resolver
enst
ENST00000706915
resolver
genesymbol
GRM8
resolver
genesymbol_syn
GPRC1H
resolver
genesymbol_syn
MGLUR8
resolver
hgnc
HGNC:4600
resolver
uniprot
A0A9L9PYG5
resolver
uniprot
A4D0Y3
resolver
uniprot
B0FZ74
resolver
uniprot
B0M0L0
resolver
uniprot
O15493
resolver
uniprot
O95945
resolver
uniprot
O95946
resolver
uniprot
Q3MIV9
resolver
uniprot
Q52M02
resolver
uniprot
Q6J165
resolver
uniprot_entry
A0A9L9PYG5_HUMAN
resolver
uniprot_entry
GRM8_HUMAN
resolver
uniprot_sec
A4D0Y3
resolver
uniprot_sec
B0FZ74
resolver
uniprot_sec
B0M0L0
resolver
uniprot_sec
O15493
resolver
uniprot_sec
O95945
resolver
uniprot_sec
O95946
resolver
uniprot_sec
Q3MIV9
resolver
uniprot_sec
Q52M02
resolver
uniprot_sec
Q6J165
resolver
amino_acid_sequence
MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:9473604}.
uniprot
proteins
mass_dalton
101741
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
pubmed
10216218
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9299241
uniprot
proteins
pubmed
9473604
uniprot
proteins
sequence_length
908
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 584..608; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 621..641; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 648..668; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 696..716; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 747..768; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 782..803; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 819..843; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins