TRIM58
entrez
25893
canonical
uniprot
Q8NG06
canonical
ensembl
ENSG00000162722
resolver
ensp
ENSP00000355437
resolver
enst
ENST00000366481
resolver
genesymbol
TRIM58
resolver
hgnc
HGNC:24150
resolver
uniprot
Q6B0H9
resolver
uniprot_entry
TRI58_HUMAN
resolver
uniprot_sec
Q6B0H9
resolver
amino_acid_sequence
MAWAPPGERLREDARCPVCLDFLQEPVSVDCGHSFCLRCISEFCEKSDGAQGGVYACPQCRGPFRPSGFRPNRQLAGLVESVRRLGLGAGPGARRCARHGEDLSRFCEEDEAALCWVCDAGPEHRTHRTAPLQEAAGSYQVKLQMALELMRKELEDALTQEANVGKKTVIWKEKVEMQRQRFRLEFEKHRGFLAQEEQRQLRRLEAEERATLQRLRESKSRLVQQSKALKELADELQERCQRPALGLLEGVRGVLSRSKAVTRLEAENIPMELKTACCIPGRRELLRKFQVDVKLDPATAHPSLLLTADLRSVQDGEPWRDVPNNPERFDTWPCILGLQSFSSGRHYWEVLVGEGAEWGLGVCQDTLPRKGETTPSPENGVWALWLLKGNEYMVLASPSVPLLQLESPRCIGIFLDYEAGEISFYNVTDGSYIYTFNQLFSGLLRPYFFICDATPLILPPTTIAGSGNWASRDHLDPASDVRDDHL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization. {ECO:0000269|PubMed:25241935}.
uniprot
proteins
mass_dalton
54766
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:25241935}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25241935
uniprot
proteins
sequence_length
486
uniprot
proteins