GPR62
entrez
118442
canonical
uniprot
Q9BZJ7
canonical
ensembl
ENSG00000180929
resolver
ensp
ENSP00000319250
resolver
enst
ENST00000322241
resolver
genesymbol
GPR62
resolver
hgnc
HGNC:13301
resolver
uniprot
F1DAM4
resolver
uniprot
Q5KU27
resolver
uniprot
Q8TAM0
resolver
uniprot_entry
GPR62_HUMAN
resolver
uniprot_entry
Q8TAM0_HUMAN
resolver
uniprot_sec
F1DAM4
resolver
uniprot_sec
Q5KU27
resolver
amino_acid_sequence
MANSTGLNASEVAGSLGLILAAVVEVGALLGNGALLVVVLRTPGLRDALYLAHLCVVDLLAAASIMPLGLLAAPPPGLGRVRLGPAPCRAARFLSAALLPACTLGVAALGLARYRLIVHPLRPGSRPPPVLVLTAVWAAAGLLGALSLLGTPPAPPPAPARCSVLAGGLGPFRPLWALLAFALPALLLLGAYGGIFVVARRAALRPPRPARGSRLHSDSLDSRLSILPPLRPRLPGGKAALAPALAVGQFAACWLPYGCACLAPAARAAEAEAAVTWVAYSAFAAHPFLYGLLQRPVRLALGRLSRRALPGPVRACTPQAWHPRALLQCLQRPPEGPAVGPSEAPEQTPELAGGRSPAYQGPPESSLS
uniprot
proteins
function
FUNCTION: Orphan G protein-coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). {ECO:0000269|PubMed:28827538}.
uniprot
proteins
mass_dalton
37614
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11165367
uniprot
proteins
pubmed
12044878
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
28827538
uniprot
proteins
sequence_length
368
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28827538}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:28827538}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with ARRB2 in the endosome (PubMed:28827538). {ECO:0000269|PubMed:28827538}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 54..74; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 130..150; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 178..198; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 240..260; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 273..293; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins