Dmtn
entrez
13829
canonical
uniprot
Q9WV69
canonical
ensembl
ENSMUSG00000022099
resolver
ensp
ENSMUSP00000022694
resolver
ensp
ENSMUSP00000106612
resolver
ensp
ENSMUSP00000153828
resolver
ensp
ENSMUSP00000153945
resolver
ensp
ENSMUSP00000154045
resolver
ensp
ENSMUSP00000154373
resolver
ensp
ENSMUSP00000315711
resolver
ensp
ENSMUSP00000315712
resolver
ensp
ENSMUSP00000315713
resolver
genesymbol
Dmtn
resolver
genesymbol_syn
Epb4.9
resolver
genesymbol_syn
Epb49
resolver
uniprot
F8WIF9
resolver
uniprot
Q3TYC5
resolver
uniprot
Q8JZV5
resolver
uniprot
Q9WVM2
resolver
uniprot_entry
DEMA_MOUSE
resolver
uniprot_sec
F8WIF9
resolver
uniprot_sec
Q3TYC5
resolver
uniprot_sec
Q8JZV5
resolver
uniprot_sec
Q9WVM2
resolver
amino_acid_sequence
MERLQKQPLTSPGSVSSSRDSSVPGSPSSIVAKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEHVELPRSRECSLSPKSTSPPPSPEVWAESRTLGIISQASTPRTTGTPRTSLPHFHHPETTRPDSNIYKKPPIYKQRESVGGSPQSKHLIEDLIIESSKFPAAQPPDPNQPAKIETDYWPCPPSLAVVETEWRKRKASRKGAEEEEEEEDDDSEEEIKAIRERQKEELSKVTSNLGKMILKEEMEKSLPIRRKTRSLPDRTPFHTSLHSGTSKSSSLPSYGRTTLSRLQSTEFSPSGSEAGSPGLQNGEGQRGRMDRGNSLPCVLEQKIYPYEMLVVTNKGRTKLPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF
uniprot
proteins
function
FUNCTION: Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:12011427, ECO:0000269|PubMed:18505823, ECO:0000269|PubMed:23060452}.
uniprot
proteins
mass_dalton
45468
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation at Ser-403 by PKA causes the C-terminal headpiece domain to associate with the N-terminal core domain, and leads to the inhibition of its actin bundling activity (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Villin/gelsolin family
uniprot
proteins
pubmed
10501976
uniprot
proteins
pubmed
11856323
uniprot
proteins
pubmed
12011427
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18505823
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23060452
uniprot
proteins
sequence_length
405
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:18505823}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18505823}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}. Membrane {ECO:0000269|PubMed:18505823}. Endomembrane system {ECO:0000250}. Cell projection {ECO:0000269|PubMed:18505823}. Note=Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane (By similarity). {ECO:0000250}.
uniprot
proteins