Rabgap1l
entrez
29809
canonical
uniprot
A6H6A9
canonical
ensembl
ENSMUSG00000026721
resolver
ensp
ENSMUSP00000028049
resolver
ensp
ENSMUSP00000028052
resolver
ensp
ENSMUSP00000275757
resolver
genesymbol
Rabgap1l
resolver
genesymbol_syn
Hhl
resolver
genesymbol_syn
Kiaa0471
resolver
uniprot
Q3UH20
resolver
uniprot
Q80TZ4
resolver
uniprot
Q8BZD2
resolver
uniprot
Q8BZP0
resolver
uniprot
Q8CFI6
resolver
uniprot
Q9QY69
resolver
uniprot_entry
RBG1L_MOUSE
resolver
uniprot_sec
Q3UH20
resolver
uniprot_sec
Q80TZ4
resolver
uniprot_sec
Q8BZD2
resolver
uniprot_sec
Q8BZP0
resolver
uniprot_sec
Q8CFI6
resolver
uniprot_sec
Q9QY69
resolver
amino_acid_sequence
MEVRASFQKVSGSSDSVATLNSEEFVLVSQHTDATSIKDDGKPQLKIASNGDEQLEKAMEEILRDSEKGQSGLPVDCQGSSEISDCPFGDVPASQTTKPPLQLILDPSNTEISTPRPSSPSRFPEEDSVLFNKLTYLGCMKVSSPRSEVEALRAMATMRASSQYPFAVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTAESNCFAFTESSHGSEEFQIHVFSCEIKEAVSRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEVKEDDGKGNFSPVPKDRDKFYFKIKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDGRAYVITGMWNPNAPIFLALNEETPKDKRVYMTVAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHSSAGDAIYEVVSLQRESDKEEPITPTSAGGPMSPQEDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGRWHNNLGGRPKGLFTLVKSGVPEALRAEVWQLLAGCHDNQEMLDKYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVFDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVTIMYGYKLRDLYRNNFEDLHCKFYQLEKLMQEQLPDLYSHFCDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQAMRENQLQQEDPMDRYKFVYL
uniprot
proteins
function
FUNCTION: GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (PubMed:27718357). {ECO:0000250|UniProtKB:Q5R372, ECO:0000269|PubMed:27718357}.
uniprot
proteins
mass_dalton
92404
uniprot
proteins
mutagenesis
MUTAGEN 584; /note="R->A: Loss GTPase-activating (GAP) activity."; /evidence="ECO:0000269|PubMed:27718357"; MUTAGEN 784..785; /note="KK->EE: Loss of interaction with ANK2. Loss of colocalization and cotransportation on motile vesicles with ANK2."; /evidence="ECO:0000269|PubMed:27718357
uniprot
proteins
pubmed
10585558
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27718357
uniprot
proteins
sequence_length
815
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:27718357}. Golgi apparatus {ECO:0000250|UniProtKB:Q5R372}. Note=Colocalizes on endosomes partially with EEA1 (By similarity). Colocalizes and cotransports on motile vesicles with ANK2 (PubMed:27718357). {ECO:0000250|UniProtKB:Q5R372, ECO:0000269|PubMed:27718357}.
uniprot
proteins