Nox3
entrez
292279
canonical
uniprot
Q672K1
canonical
ensembl
ENSRNOG00000016490
resolver
ensembl
ENSRNOG00055028772
resolver
ensembl
ENSRNOG00060008694
resolver
ensembl
ENSRNOG00065028038
resolver
ensp
ENSRNOP00000022148
resolver
ensp
ENSRNOP00055041045
resolver
ensp
ENSRNOP00060011196
resolver
ensp
ENSRNOP00065039666
resolver
enst
ENSRNOT00000022148
resolver
enst
ENSRNOT00055049847
resolver
enst
ENSRNOT00060014539
resolver
enst
ENSRNOT00065048343
resolver
genesymbol
Nox3
resolver
uniprot_entry
NOX3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by the ototoxic drug cisplatin. Activated by NOXO1. Cooperatively activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)-dependent manner. Inhibited by diphenyleneiodonium chloride (By similarity). {ECO:0000250|UniProtKB:Q672J9}.
uniprot
proteins
amino_acid_sequence
MPTCWILNESVSFVVALLWLAINIYLFIDTFCWYAEEESFFYTRVILGSALAWARASAVCLNFNCMLILLPVSRNFVSLVRGTSVCCRGPWRRQLDKNLKFHKLVAYGIAVNSVIHIVAHLFNLERYHLGQAKDAEGLLAALSKLGNAPNESYLNPVRTLYTGTTTQLLMTVSGITGLVISLALILIMTSSTEFIRQSSYELFWYTHHIFIFLFISLAIHGGGRIIRGQTPESLRLHNVTFCRDHFDEWQEAASCPVPQFSGKEPSAWKWTLGPVVLYACEIIIRFWRSHQEVVITKVVSHPSAVLELHMKKRDFKMAPGQYIFIQCPSISPLEWHPFTLTSAPQEDFFSVHIRASGDWTEALLKAFGAEGQAPSELCSMPRLAVDGPFGGSLADVFHYPVSVCIATGIGVTPFASLLKSVWYKCCESQSLPGLSKVYFYWICRDAAAFEWFADLLLSLETQMSEQGKAHLLSYHIYLTGWDEYQAIHIALHWDESLDVITGLKQKTFYGRPNWNEEFKQIAYNHPSSSIGVFFCGPKAMSKTLQKMCRLYSSSDPRGVHFYYNKENF
uniprot
proteins
ec_number
1.6.3.-
uniprot
proteins
function
FUNCTION: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor, upon formation of a complex with CYBA/p22phox (By similarity). Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (By similarity). {ECO:0000250|UniProtKB:Q672J9}.
uniprot
proteins
mass_dalton
64416
uniprot
proteins
post_translational_modification
PTM: N-glycosylated in a CYBA/p22phox-dependent manner. {ECO:0000250|UniProtKB:Q672J9}.
uniprot
proteins
pubmed
15326186
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q672J9}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 50..70; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 396..416; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins