Rasgrf1
entrez
19417
canonical
uniprot
P27671
canonical
ensembl
ENSMUSG00000032356
resolver
ensp
ENSMUSP00000034909
resolver
ensp
ENSMUSP00000034912
resolver
ensp
ENSMUSP00000191347
resolver
ensp
ENSMUSP00000361896
resolver
enst
ENSMUST00000034909
resolver
enst
ENSMUST00000034912
resolver
genesymbol
Rasgrf1
resolver
genesymbol_syn
Cdc25
resolver
genesymbol_syn
Grf1
resolver
uniprot
B2RS27
resolver
uniprot
F7B4Z9
resolver
uniprot
Q9QZR7
resolver
uniprot_entry
B2RS27_MOUSE
resolver
uniprot_entry
F7B4Z9_MOUSE
resolver
uniprot_entry
Q9QZR7_MOUSE
resolver
uniprot_entry
RGRF1_MOUSE
resolver
amino_acid_sequence
MQKAIRLNDGHVVTLGLLAQKDGTRKGYLSKRSADNPKWQTKWFALLQNLLFYFESDSSPRPSGLYLLEGSICKRAPSPKRGTSSKESGEKQQHYFTVNFSNDSQKTLELRTEDAKDCDEWVAAIARASYKILATEHEALMQKYLHLLQVVETEKTVAKQLRQQLEDGEVEIERLKTEVTITNLIKDNDRIQSSNKAGSADDEDSDIKKIKKVQSFLRGWLCRRKWKNIIQDYIRSPHADSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLHQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLLKQYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELSRIMHDEVSETENIRKNLAIERMITEGCEILLDTSQTFVRQGSLMQMSLSEKSKSSRGRLGSLSTKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLDEPENLDDEAKGAGPEIEHLEFKIGVEPKDSLPFTVILVASTRQEKAAWTSDIIQCVDNIRCNGLMMNAFEENSKVTVPQMIKSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERLTDLRFLSIDFLNTFLHSYRVFTNAMVVLDKLINIYRKPMSAIPARSLELLFSSSHNAKLLYGDAPKSPRASRKFSSPPPLAIGTSSPSRRRKLSLNIPIITGGKALELASLGCSSDSYANIHSPISPFGKTTLDTGKLCMASSLPKTPEEIDVPATIPEKPGELSASRKHSSDVLKEESEDDQNHSDEDNTEVSPVKSPPTPKSFLNRTITEFPFFNYNNGILMTTCRDLVDNNRSTLSATSAFAIATAGANEGPSNKEVFRRMSLANTGFSSDQRNIDKEFVIRRAATNRVLNVLRHWVTKHTQDFDTDDTLKYRVICFLEEVMHDPDLLTQERKAAANIIRTLTLEETTEQHSMLEEVILMTEGVKTEPFENHPALEIAEQLTLLDHLVFKSIPYEEFFGQGWMKAEKYERTPYIMKTTKHFNHVSNFIASEIIRNEDISARASAIEKWVAVADICRCLHNYNAVLEITSSINRSAIFRLKKTWLKVSKQTKSLLDKLQKLVSSDGRFKNLRESLRNCDPPCVPYLGMYLTDLVFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTTYKIDPQPKVIQYLLDESFMLDEESLYESSLLIEPKLPT
uniprot
proteins
function
FUNCTION: Promotes the exchange of Ras-bound GDP by GTP. {ECO:0000269|PubMed:10373510}.
uniprot
proteins
mass_dalton
144102
uniprot
proteins
mutagenesis
MUTAGEN 263; /note="L->Q: Loss of function and oligomerization."; /evidence="ECO:0000269|PubMed:10373510"; MUTAGEN 394..400; /note="LTLHELL->IIIRDII: Partial loss of function. No effect on oligomerization."; /evidence="ECO:0000269|PubMed:10373510
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome. {ECO:0000250}.; PTM: Ubiquitinated and degraded following phosphorylation by PLK2. {ECO:0000305|PubMed:11500497}.; PTM: Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC does not seem to have an effect on stimulation activity (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
10373510
uniprot
proteins
pubmed
11500497
uniprot
proteins
pubmed
1376246
uniprot
proteins
pubmed
1379731
uniprot
proteins
pubmed
1396590
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1262
uniprot
proteins