Fmo5
entrez
14263
canonical
uniprot
P97872
canonical
ensembl
ENSMUSG00000028088
resolver
ensp
ENSMUSP00000029729
resolver
ensp
ENSMUSP00000102664
resolver
ensp
ENSMUSP00000102665
resolver
ensp
ENSMUSP00000272386
resolver
ensp
ENSMUSP00000272387
resolver
enst
ENSMUST00000029729
resolver
enst
ENSMUST00000107049
resolver
enst
ENSMUST00000107050
resolver
genesymbol
Fmo5
resolver
uniprot
Q3TRA1
resolver
uniprot
Q8R1W6
resolver
uniprot_entry
FMO5_MOUSE
resolver
uniprot_entry
Q3TRA1_MOUSE
resolver
uniprot_sec
Q8R1W6
resolver
amino_acid_sequence
MAKKRIAVIGAGASGLTCIKCCLEEGLEPVCFERSGDIGGLWRFQEAPEEGRASIYQSVVINTSKEMMCFSDYPIPDHYPNYMHNSQVLEYFRMYAKEFDLLKYIQFKTTVCSVKKQPDFSTSGQWQVVTECEGKQQVDVFDGVLVCTGHHTDAHLPLESFPGIEKFKGKYFHSRDYKNPVEFTGKRVIVIGIGNSGGDLAVEISHTAKQVFLSTRRGAWILNRVGKHGYPIDLLLSSRIMYYLSRICGPSLKNNYMEKQMNQRFDHEMFGLKPKHRALSQHPTVNDDLPNRIIAGLVKVKGNVKEFTETAAVFEDGSREDGIDVVIFATGYSFAFPFLEDSVKVVKNKVSLYKKVFPPNLEKPTLAIIGLIQPLGAIMPISELQGRWATQVFKGLKKLPSQSEMMAEINKAREEMAKRYVDSQRHTIQGDYIDTMEEIADLVGVRPNILPLVFTDPRLALRLLLGPCTPVQYRLQGPGKWAGARKTILTTEDRVRKPLMTRVVERDSSGGSLVTVRVLMLAVAFFAVILAYF
uniprot
proteins
ec_number
1.14.13.8
uniprot
proteins
ec_number
1.6.3.1
uniprot
proteins
function
FUNCTION: Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (By similarity). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (PubMed:26049045, PubMed:28646079). {ECO:0000250|UniProtKB:P49326, ECO:0000269|PubMed:26049045, ECO:0000269|PubMed:28646079}.
uniprot
proteins
mass_dalton
60001
uniprot
proteins
protein_family
FMO family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26049045
uniprot
proteins
pubmed
28646079
uniprot
proteins
pubmed
29686991
uniprot
proteins
pubmed
9580872
uniprot
proteins
sequence_length
533
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:P49326}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P49326}.
uniprot
proteins
transmembrane_region
TRANSMEM 513..533; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins