Socs3
entrez
89829
canonical
uniprot
O88583
canonical
ensembl
ENSRNOG00000063373
resolver
ensp
ENSRNOP00000097273
resolver
ensp
ENSRNOP00000108465
resolver
ensp
ENSRNOP00000108489
resolver
ensp
ENSRNOP00000109646
resolver
ensp
ENSRNOP00000111511
resolver
enst
ENSRNOT00000118098
resolver
enst
ENSRNOT00000142846
resolver
enst
ENSRNOT00000145627
resolver
enst
ENSRNOT00000145772
resolver
enst
ENSRNOT00000161353
resolver
genesymbol
Socs3
resolver
genesymbol_syn
Cish3
resolver
uniprot
G3V6D2
resolver
uniprot
Q9QYV5
resolver
uniprot_entry
G3V6D2_RAT
resolver
uniprot_entry
SOCS3_RAT
resolver
uniprot_sec
Q9QYV5
resolver
amino_acid_sequence
MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVETQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFSLPPTEPSFEVQEQPPAQALPGGTPKRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
uniprot
proteins
function
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway (By similarity). Inhibits signal transduction by binding to transmembrane signaling receptors including IL6ST/gp130, LIFR, EPOR, INSR, IL12RB2, CSF3R/G-CSF-R and LEPR. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Upon OSM stimulation, negatively regulates the JAK-STAT signaling mediated through type II OSM receptor complex by interacting directly with JAK1 (By similarity). {ECO:0000250|UniProtKB:O14543, ECO:0000250|UniProtKB:O35718}.
uniprot
proteins
mass_dalton
24808
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1. {ECO:0000250}.
uniprot
proteins
pubmed
10579313
uniprot
proteins
pubmed
11108838
uniprot
proteins
sequence_length
225
uniprot
proteins