Pus10
entrez
74467
canonical
uniprot
Q9D3U0
canonical
ensembl
ENSMUSG00000020280
resolver
ensp
ENSMUSP00000020520
resolver
ensp
ENSMUSP00000050395
resolver
ensp
ENSMUSP00000105151
resolver
ensp
ENSMUSP00000260360
resolver
ensp
ENSMUSP00000260361
resolver
ensp
ENSMUSP00000260363
resolver
ensp
ENSMUSP00000260364
resolver
ensp
ENSMUSP00000260371
resolver
ensp
ENSMUSP00000260381
resolver
enst
ENSMUST00000020520
resolver
enst
ENSMUST00000058163
resolver
enst
ENSMUST00000109525
resolver
genesymbol
Pus10
resolver
genesymbol_syn
Ccdc139
resolver
uniprot
Q3UM90
resolver
uniprot
Q8BSZ4
resolver
uniprot
Q8CDM2
resolver
uniprot
Q9CSI7
resolver
uniprot_entry
PUS10_MOUSE
resolver
uniprot_sec
Q3UM90
resolver
uniprot_sec
Q8BSZ4
resolver
uniprot_sec
Q8CDM2
resolver
uniprot_sec
Q9CSI7
resolver
amino_acid_sequence
MLPLTEENKHVAQLLFSSGTCPRCILRFCGVDLPAPYKHPSKELLNELQKFLEPEKPELILEAPNPPLKKIRLHEDGIDNLSEDGKEGVSVTEDESMAEKPSKLRVCNVCLGILQEFCEKGFITKVCQKVEASGFEFTSVVLSVSFPPQLSVREHAAWLLVKQEMGKQSLSLGRNDVVQLKEAYKWITHPLFSEELGVPTDGKSLFEVSVVFAHPETAEDCHFLGEVCRDCFKPAKNKQSVFTRMAVLKALSKIKEEDFLGQFPCPPNSPKTVCTVLEVECTHGAVFVAGRYNKYSRNLPQTPWIIDGERKMESSVEELISDHLLAVFRAESFNFSSSGREDVDVRTLGNGRPFAVELLNPHRVHFTSQEMKELQQTINKSSDKIQVRDLQLVTREAIGHMKEGEEEKTKTYSALIWTNRAIQKKDIGFLDDLKDLKIDQKTPLRVLHRRPLAVRTRAIHSMKTHYLDEHHFRLHLKTQAGTYIKEFVHGDFGRTKPNLGSLMNVTADILELDVESVDVDWPPALDD
uniprot
proteins
ec_number
5.4.99.25
uniprot
proteins
function
FUNCTION: Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm. In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs. tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs. Does not show tRNA pseudouridylate synthase activity in the nucleus. In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity. Binds pri-miRNAs. Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death. {ECO:0000250|UniProtKB:Q3MIT2}.
uniprot
proteins
mass_dalton
59710
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved during TRAIL-induced cell death. Cleaved, in vitro, either by caspase-3 (CASP3) or caspase-8 (CASP8). {ECO:0000250|UniProtKB:Q3MIT2}.
uniprot
proteins
protein_family
Pseudouridine synthase Pus10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
527
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3MIT2}. Cytoplasm {ECO:0000250|UniProtKB:Q3MIT2}. Mitochondrion {ECO:0000250|UniProtKB:Q3MIT2}. Note=Localizes mainly in the nucleus. tRNA pseudouridylate synthase activity is restricted to the cytoplasm. Translocates from nucleus to mitochondria during TRAIL-induced apoptosis. {ECO:0000250|UniProtKB:Q3MIT2}.
uniprot
proteins