Scn7a
entrez
20272
canonical
uniprot
B1AYL1
canonical
ensembl
ENSMUSG00000034810
resolver
ensp
ENSMUSP00000042405
resolver
enst
ENSMUST00000042792
resolver
genesymbol
Scn7a
resolver
genesymbol_syn
Nag
resolver
genesymbol_syn
Nav2
resolver
genesymbol_syn
scl11
resolver
uniprot
Q62467
resolver
uniprot_entry
SCN7A_MOUSE
resolver
uniprot_sec
Q62467
resolver
amino_acid_sequence
MLTSPEPKGLVPFTTESLELIENHIAKKCNEDPEEEEGLKPSRNLEAGKRLPIPYGTLPRGTVSEPLEDVDPYYYVKRNTFMVLNRSRVIFRFNAVSIFCTLSPLNSLRRAAIKALVHPLFRLLILISVLTDSILMCMSNLPEWILAIENTLLGIYAFEILVKVIARGIWAGSFSFLGDLWNWLDFSVTLFELITRFSPLSSFLMLKTIRTFRILKIIPLNHGLQSIVMTLAQCLKKLFGAIALALFFLAVFSLLGMGLFMGNLKHKCLRWPEENENETLHNRTGSLNYSPERINFYYMEGAKYALLCGNRTDAGQCPEGYVCVKEGTNPDNGFTSFDNFGWSLLAMFRLMTQDYPELLYHQILYASGKVYMIFFVMISFWFAFYLTSLFLGILTMTYEKEKQRACEESGGLDPKCQQTVKELDEENDAAEMETTQIEMKKRSPTSINTTLDILEDTTLGHREEPETSRKKCPICWHKFIKTCFIWKCSPCWVKLNEFADRVITHPLADLFLVICIVLNICFLALEHFPMSEELRSLLHVGNLVFIGIYTIEMILKIIAMHPYGYFQISWNIFDSILVVLELTEILLADVEGLAVLITVPLIFIKLGKYGPPFKSLMRILGSSLMALKDLVLLLCIFVYFSAVFGMKLFGRSYKDCVCHIKEDCQPQRWHMSDFLHAYMTVFRILCGEWIETLWECMEVAGQAWCIPFYMMVILIGNLLILYLFVTLVSSFSYYDATSEVNKEAKNLQLAMARIKSGINSMLLKLMCTERSVPTEATDQICDPSVKENISGHTLSELSNTQTFLRYKDQSSSTEKTPVTESESQSLIASPSASETVPIASGESDIENLDNKETRSKSGNGGSKEKMKQSSSSECSTVDIAISEEEEMVYEHEKSKLHKNGYERKSSTGQISRESRNGKIWKNIRKTCCKIVENSWFECFIGLVTLLCTGTLALEDIYIDQRKTTKILLEYADMIFAYIFILEMLLKWVAYGFKAFFSNNWYKLDFMVVIVFCLSLIGKTREDLNPLTSIKFLRALRVLSQFERMKVVLRALIKTTLPTVSVFLVCLMIWLLFSVIGVQLFAGKFYECIDPTKGERFPVFEVMNKSQCEKLLFNESMPWENAKLNFDNVGNGFLSLLQVATFNGWISIMNSAIDSVGVNMQPSFEYNLYMYSYFIIFVIFGLFLPLCMLIGVIIRNFNKQKIKQGGSNIFITVKQKKQYRALKKLLYADVQKPTPRPRNKFQGFLFDLVTHRVFNVIIILLICFQATTIMIQKDEQSPQMETAIFWMNSIFVMLFTLECILKLTAFRCHYFTSAWNVHDFMVVIFSITGLLLPLTIGQYFVPPSLVQLILLSRVIHILRPGKGPKVFHDLMLPLILALPALLNISLLIFLVMFIYAIFGMYNFAYVKKEAGINDVSNFETFGSSMLCLFQVTTFSGWDGMLDAIFNSQWSDCDPDKINPGTQVKGDCGSPSVGISYFVSYILISWLIIVNMYIVLIMEFLSIPSQKKSRTLSEDDFRRFFRVWNRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLVAMDLPMAAGDRIHCLDILLAFTKRVMGKDERVEKILSEIESGFMLANPFKITYEPITTTLKRKQEAVSATIIQRAYKSYRLRQNDKNVSDTPAIDDRRDDLTSKGAHSGKIEEKASIQTQI
uniprot
proteins
function
FUNCTION: Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient (PubMed:11027237, PubMed:11992118, PubMed:17408578, PubMed:27252474). In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body (PubMed:11027237, PubMed:17408578, PubMed:27252474). By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis (By similarity). {ECO:0000250|UniProtKB:Q01118, ECO:0000269|PubMed:11027237, ECO:0000269|PubMed:11992118, ECO:0000269|PubMed:17408578, ECO:0000269|PubMed:27252474}.
uniprot
proteins
mass_dalton
192177
uniprot
proteins
protein_family
SCN7A subfamily
uniprot
proteins
protein_family
Sodium channel (TC 1.A.1.10) family
uniprot
proteins
pubmed
11027237
uniprot
proteins
pubmed
11992118
uniprot
proteins
pubmed
17408578
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27252474
uniprot
proteins
pubmed
7982916
uniprot
proteins
sequence_length
1681
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17408578}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 119..138; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 143..168; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 180..197; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 202..220; /note="Helical; Name=S4 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 239..260; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 369..408; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 507..522; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 532..560; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 570..587; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 594..609; /note="Helical; Name=S4 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 627..655; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 702..732; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 935..953; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 962..990; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 999..1020; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1022..1040; /note="Helical; Name=S4 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1056..1080; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1168..1202; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1251..1272; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1277..1305; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1313..1338; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1342..1362; /note="Helical; Name=S4 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1378..1402; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1469..1504; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q01118
uniprot
proteins