Dync1li1
entrez
252902
canonical
uniprot
Q9QXU8
canonical
ensembl
ENSRNOG00000010434
resolver
ensp
ENSRNOP00000014532
resolver
enst
ENSRNOT00000014532
resolver
genesymbol
Dync1li1
resolver
genesymbol_syn
Dncli1
resolver
uniprot
G3V7G0
resolver
uniprot_entry
DC1L1_RAT
resolver
uniprot_entry
G3V7G0_RAT
resolver
amino_acid_sequence
MAAVGRVGSFGSSPPGLASTYASGPLANELASGSGGPAAGDDEDGQNLWSRILREVSTRSRSKLPTGKNVLLLGEDGAGKTSLIRRIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDALSLRDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKEMEQKLIRDFQEYVEPGEDFPASPQRRATAAQEDRDDSVVLPLGADTLTHNLGLPVLVVCTKCDAISVLEKEHDYRDEHFDFIQSHIRKFCLQYGAALIYTSVKENKNIDLVYKYIVQKLYGFPYKIPAVVVEKDAVFIPAGWDNDKKIGILHENFQTLKIEDNFEDIITKPPVRKFVHEKEIMAEDDQVFLMKLQSLLAKQPPTAAGRPVDASPRVPGGSPRTPNRSVSSNVASVSPIPAGSKKIDPNMKAGATSEGVLANFFNSLLSKKTGSPGGPGVGGSPGGGAAGASTSLPPSAKKSGQKPVLSDVHAELDRITRKPASVSPTTPPSPTEGEAS
uniprot
proteins
function
FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores (By similarity). Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9Y6G9}.
uniprot
proteins
mass_dalton
56792
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during mitosis but not in interphase. {ECO:0000250}.
uniprot
proteins
protein_family
Dynein light intermediate chain family
uniprot
proteins
pubmed
10545494
uniprot
proteins
pubmed
10893222
uniprot
proteins
pubmed
10893223
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9Y6G9}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9Y6G9}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9Y6G9}.
uniprot
proteins