Ghsr
entrez
208188
canonical
uniprot
Q99P50
canonical
ensembl
ENSMUSG00000051136
resolver
ensp
ENSMUSP00000061153
resolver
enst
ENSMUST00000057186
resolver
genesymbol
Ghsr
resolver
uniprot
Q0VBE5
resolver
uniprot
Q8BWX8
resolver
uniprot
Q91Z82
resolver
uniprot_entry
GHSR_MOUSE
resolver
uniprot_entry
Q0VBE5_MOUSE
resolver
uniprot_sec
Q8BWX8
resolver
uniprot_sec
Q91Z82
resolver
activity_regulation
ACTIVITY REGULATION: Activated by octanoylated ghrelin; octanoylation is essential for full activation of the receptor (By similarity). Stimulated by anamorelin, which binds to the same binding sites as ghrelin (By similarity). {ECO:0000250|UniProtKB:Q92847}.
uniprot
proteins
amino_acid_sequence
MWNATPSEEPEPNVTLDLDWDASPGNDSLSDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGSSLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
uniprot
proteins
function
FUNCTION: G protein-coupled receptor specific to ghrelin, an appetite-regulating peptide hormone commonly found in stomach (By similarity). Upon activation, stimulates appetite and promotes growth hormone secretion (PubMed:15070777, PubMed:16322794). Ghrelin binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (By similarity). GHSR is coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (By similarity). Also binds other growth hormone releasing peptides (GHRP) as well as non-peptide, low molecular weight secretagogues (By similarity). Also plays a role in synaptic plasticity independently of ghrelin by forming a heteromer with the dopamine receptors DRD1 and DRD2 in neurons (PubMed:22284186, PubMed:26590421). Following DRD1 activation by dopamine in hippocampal neurons, GHSR acts as a coreceptor, resulting in DRD1 coupling to G(q) at the expense of G(s), initiating hippocampal synaptic plasticity involved in memory and learning (PubMed:26590421). Following DRD2 activation by dopamine in lumbosacral defecation centers, GHSR acts as a coreceptor, resulting in DRD1 coupling to G(q) at the expense of G(i)/G(o), regulating defecation (PubMed:40441153). {ECO:0000250|UniProtKB:Q92847, ECO:0000269|PubMed:15070777, ECO:0000269|PubMed:16322794, ECO:0000269|PubMed:22284186, ECO:0000269|PubMed:26590421, ECO:0000269|PubMed:40441153}.
uniprot
proteins
mass_dalton
40969
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15070777
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16322794
uniprot
proteins
pubmed
22284186
uniprot
proteins
pubmed
26590421
uniprot
proteins
pubmed
40441153
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q92847}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q92847}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..65; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q92847"; TRANSMEM 72..95; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q92847"; TRANSMEM 117..138; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q92847"; TRANSMEM 162..182; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q92847"; TRANSMEM 211..234; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q92847"; TRANSMEM 262..283; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q92847"; TRANSMEM 301..324; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q92847
uniprot
proteins