Crb2
entrez
241324
canonical
uniprot
Q80YA8
canonical
ensembl
ENSMUSG00000035403
resolver
ensp
ENSMUSP00000058007
resolver
enst
ENSMUST00000050372
resolver
genesymbol
Crb2
resolver
uniprot
A2ALU1
resolver
uniprot
Q6P6N1
resolver
uniprot_entry
CRUM2_MOUSE
resolver
uniprot_sec
A2ALU1
resolver
uniprot_sec
Q6P6N1
resolver
amino_acid_sequence
MALVGPRIWGPRRDIYPLLLLLLLLLLLLLPWVPAGLVPPETPSVCASDPCAPGTKCQATESGGYTCEPSELGGCATQPCHHGALCVPQGPDPNSFRCYCVPGFQGPHCELDIDECASRPCQHGGTCQNLADHYECHCPLGYAGVTCEAEVDECSSAPCLHGGSCLDGVGSYRCVCAPGYAGANCQLDVDECQSQPCAHGGVCHDLVNGFRCDCADTGYEGARCEQEVLECASAPCAHNASCLDGFRSFRCLCWPGFSGERCEVDEDECASGPCQNGGQCLQRSDPTLYGGVQAIFPGAFSFSHAAGFLCSCPLGFAGNDCSMDVDECASGPCLNGGSCQDLPNGFQCYCQDGYTGLTCQEDMDECQSEPCLHGGTCSDTVAGYICQCPEAWGGHDCSVQLTGCQGHTCPLAATCIPTFKSGLHGYFCRCPPGTYGPFCGQNTTFSVVSGSSVWGLVPAAASLGLALRFRTTLLAGTLATLKDTRDSLELVLVGAVLQATLSRHGTAVLILTLPDLALNDGHWHQVEVTLHLGTLELRLWHEGCPGQLCVASGPVATGPTASVASGPPGSYSIYLGGGVFAGCFQDVRVEGHLLLPEELKGTVLLGCERREPCQPLPCAHGGACVDLWTHFRCDCPRPYRGATCTDEVPAATFGLGGATSSASFLLHQLGPNLTVSFFLRTREPAGLLLQFANDSVASLTVFLSEGQIRAEGLGHPAVVLPGRWDDGLPHLVMLSFGPDQLQDLGQRLYVGGRFYPDDTQLWGGPFRGCLQDLQLNSIHLPFFSSPMENSSWPSELEAGQSSNLTQGCVSEDTCNPNPCFNGGTCHVTWNDFYCTCSENFTGPTCAQQRWCPRQPCLPPATCEEVPDGFVCVAEATFREGPPAVFTGHNVSSSLSGLTLAFRTRDSEAGLLRAVSAAGAHSNIWLAVRNGSLAGDVAGSVLPAPGPRVADGAWHRVRLAREFPQAAASRWLLWLDGAATPVALHGLGGDLGFLQGPGAVPLLLAENFTGCLGRVALGDFPLPLAPPRSGTVSGAREHFVAWPGSPAVSLGCRGGPVCSPSPCLHGGACRDLFDAFACSCGPAWEGPRCEIRADPCRSTPCVRGQCHARPDGRFECRCPPGFSGPRCRLPVLPQGCNLNSTCKDGAPCEGGPLGTNCSCQEGLAGLRCQSLDKPCEASPCLNGGTCRVASGIFECTCSAGFSGQFCEVVKTLPLPLPFPLLEVAVPAACACLLLLLLGLLSGILAARKRRQSEGTYSPSQQEVAGARLEMDSVLKVPPEERLI
uniprot
proteins
function
FUNCTION: Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo (PubMed:26496195, PubMed:27870829). Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer (PubMed:27870829). The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB (PubMed:27870829). Also required for maintenance of the apical polarity complex during development of the cortex. {ECO:0000269|PubMed:26496195, ECO:0000269|PubMed:26802325, ECO:0000269|PubMed:27870829}.
uniprot
proteins
mass_dalton
134760
uniprot
proteins
post_translational_modification
PTM: O-glucosylated by POGLUT1 at Ser-271; consists of an O-glucose trisaccharide, in which the O-glucose is elongated by the addition of two xylose residues (PubMed:26496195). O-glucosylation is required for localization at the plasma membrane (PubMed:26496195). {ECO:0000269|PubMed:26496195}.
uniprot
proteins
protein_family
Crumbs protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15851977
uniprot
proteins
pubmed
17920587
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22072575
uniprot
proteins
pubmed
23001562
uniprot
proteins
pubmed
26496195
uniprot
proteins
pubmed
26802325
uniprot
proteins
pubmed
27870829
uniprot
proteins
sequence_length
1282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:17920587, ECO:0000269|PubMed:26496195, ECO:0000269|PubMed:27870829}; Single-pass type I membrane protein {ECO:0000255}. Note=O-glucosylation is required for localization at the apical plasma membrane (PubMed:26496195). Distributed in a complex anisotropic pattern on apical cell edges: the level of CRB2 on a cell edge is inversely correlated with the level of MYH10/myosin-IIB (PubMed:27870829). {ECO:0000269|PubMed:26496195, ECO:0000269|PubMed:27870829}.
uniprot
proteins
transmembrane_region
TRANSMEM 1222..1242; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins