Slc4a2
entrez
24780
canonical
uniprot
P23347
canonical
ensembl
ENSRNOG00000014347
resolver
ensembl
ENSRNOG00055022682
resolver
ensembl
ENSRNOG00060021745
resolver
ensembl
ENSRNOG00065017378
resolver
ensp
ENSRNOP00000019666
resolver
ensp
ENSRNOP00000077442
resolver
ensp
ENSRNOP00055031664
resolver
ensp
ENSRNOP00060031771
resolver
ensp
ENSRNOP00065023080
resolver
enst
ENSRNOT00000019666
resolver
enst
ENSRNOT00000111245
resolver
enst
ENSRNOT00055038994
resolver
enst
ENSRNOT00060038512
resolver
enst
ENSRNOT00065029119
resolver
genesymbol
Slc4a2
resolver
genesymbol_syn
Ae2
resolver
genesymbol_syn
B3rp2
resolver
uniprot
A0A8I5Y5U0
resolver
uniprot_entry
A0A8I5Y5U0_RAT
resolver
uniprot_entry
B3A2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS). {ECO:0000269|PubMed:2371270}.
uniprot
proteins
amino_acid_sequence
MSSAPRRPASGADSLHTPEPESLSPGTPGFPEQEEEDELRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEVGEAEGFRAPPQQPSPASSPSAVQFFLQEDEGTDRKAERTSPSPPTQTPHQEAAPRASKGAQTGTLVEEMVAVASGTAGGDDGGAAGRPLTKAQPGHRSYNLQERRRIGSMTGVEQALLPRVPTDESEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQAAREGREPGPTPRARPRAPHKPHEVFVELNELQLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKEFSFPRNISAGSLGSLLGHHHAQGTESDPHVTEPLIGGVPETRLEVDRERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADERDDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPPGAGLEPKSAQDKALLQMVEVAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVIFCLLGAQPLLVIGFSGPLLVFEEAFFSFCKSNQLEYLVGRVWIGFWLVLLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLIKIFQEHPLHGCSVSNDSEADSSSNNMTWAATTLAPDNSSASGQERPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPDKRGWVINPLGEKTPFPVWMMVASLLPAVLVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSMVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTMRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTEREMKCLDANEAEPVFDECEGVDEYNEMPMPV
uniprot
proteins
function
FUNCTION: Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:2371270). Plays an important role in osteoclast differentiation and function (By similarity). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). {ECO:0000250|UniProtKB:P13808, ECO:0000269|PubMed:2371270}.
uniprot
proteins
mass_dalton
136636
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
10600827
uniprot
proteins
pubmed
22310983
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2294114
uniprot
proteins
pubmed
2371270
uniprot
proteins
pubmed
8141271
uniprot
proteins
sequence_length
1234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:22310983}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:10600827, ECO:0000269|PubMed:8141271}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 705..728; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 734..771; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 791..813; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 823..843; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 894..911; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 927..947; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 981..1003; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1029..1050; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1084..1129; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1156..1192; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins