Gatm
entrez
81660
canonical
uniprot
P50442
canonical
ensembl
ENSRNOG00000000168
resolver
ensp
ENSRNOP00000000181
resolver
genesymbol
Gatm
resolver
genesymbol_syn
Agat
resolver
uniprot
Q6ITZ7
resolver
uniprot_entry
GATM_RAT
resolver
uniprot_sec
Q6ITZ7
resolver
amino_acid_sequence
MLRVRCLRGGSRGAEAVHYIGSRLGGSLTGWVQRTFQSTQAATASSQNSCAAEDKATHPLPKDCPVSSYNEWDPLEEVIVGRAENACVPPFTVEVKANTYEKYWPFYQKNGGLYFPKDHLKKAVAEVEEMCNILSMEGVTVKRPDPIDWSLKYKTPDFESTGLYSAMPRDILMVVGNEIIEAPMAWRSRFFEYRAYRSIIKDYFHRGAKWTTAPKPTMADELYDQDYPIHSVEDRHKLAAQGKFVTTEFEPCFDAADFIRAGRDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFKDPNPMHIDATFNIIGPGLVLSNPDRPCHQIDLFKKAGWTIVTPPTPVIPDDHPLWMSSKWLSMNVLMLDEKRVMVDANEVPIQKMFEKLGISTIKVNIRNANSLGGGFHCWTCDVRRRGTLQSYFD
uniprot
proteins
ec_number
2.1.4.1
uniprot
proteins
function
FUNCTION: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives (PubMed:6766137, PubMed:8035648). Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine (By similarity). Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (PubMed:6766137). {ECO:0000250|UniProtKB:P50440, ECO:0000269|PubMed:6766137, ECO:0000305|PubMed:8035648}.
uniprot
proteins
mass_dalton
48242
uniprot
proteins
pathway_participation
PATHWAY: Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 1/2. {ECO:0000305|PubMed:6766137}.
uniprot
proteins
protein_family
Amidinotransferase family
uniprot
proteins
pubmed
11165387
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15918910
uniprot
proteins
pubmed
19826191
uniprot
proteins
pubmed
3057136
uniprot
proteins
pubmed
3512696
uniprot
proteins
pubmed
6384218
uniprot
proteins
pubmed
6766137
uniprot
proteins
pubmed
8021264
uniprot
proteins
pubmed
8035648
uniprot
proteins
pubmed
9623603
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}.
uniprot
proteins