G6pdx
entrez
14381
canonical
uniprot
Q00612
canonical
ensembl
ENSMUSG00000031400
resolver
ensp
ENSMUSP00000004327
resolver
enst
ENSMUST00000004327
resolver
genesymbol
G6pdx
resolver
genesymbol_syn
G6pd
resolver
genesymbol_syn
G6pd-1
resolver
uniprot
Q790Y8
resolver
uniprot_entry
G6PD1_MOUSE
resolver
uniprot_entry
Q790Y8_MOUSE
resolver
amino_acid_sequence
MAEQVALSRTQVCGILREELYQGDAFHQADTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPEDTFIVGYARSRLTVDDIRKQSEPFFKATPEERPKLEEFFARNSYVAGQYDDAASYKHLNSHMNALHQGMQANRLFYLALPPTVYEAVTKNIQETCMSQTGWNRIIVEKPFGRDLQSSNQLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPATTGSDDVRDEKVKVLKCISEVETDNVVLGQYVGNPNGEGEAANGYLDDPTVPHGSTTATFAAAVLYVENERWDGVPFILRCGKALNERKAEVRLQFRDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHKIDREKPQPIPYVYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL
uniprot
proteins
ec_number
1.-.-.-
uniprot
proteins
ec_number
1.1.1.49
uniprot
proteins
function
FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (PubMed:12831846). Also catalyzes the conversion of NAADPH, which is produced by enzymes such as DUOX1, DUOX2 and NOX5 from NAADP and promotes Ca(2+) signaling during T cell activation, back to NAADP (By similarity). {ECO:0000250|UniProtKB:P11413, ECO:0000269|PubMed:12831846}.
uniprot
proteins
mass_dalton
59263
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. {ECO:0000269|PubMed:12831846}.
uniprot
proteins
post_translational_modification
PTM: Acetylated by ELP3 at Lys-403; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2 at Lys-403; deacetylation stimulates its enzyme activity (By similarity). {ECO:0000250|UniProtKB:P11413}.
uniprot
proteins
protein_family
Glucose-6-phosphate dehydrogenase family
uniprot
proteins
pubmed
12831846
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
1874446
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
35122041
uniprot
proteins
pubmed
8400362
uniprot
proteins
pubmed
9330624
uniprot
proteins
sequence_length
515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P11413}. Membrane {ECO:0000250|UniProtKB:P11413}; Peripheral membrane protein {ECO:0000250|UniProtKB:P11413}.
uniprot
proteins