Spc24
entrez
67629
canonical
uniprot
Q9D083
canonical
ensembl
ENSMUSG00000074476
resolver
ensp
ENSMUSP00000096541
resolver
ensp
ENSMUSP00000151082
resolver
enst
ENSMUST00000216057
resolver
genesymbol
Spc24
resolver
genesymbol_syn
Spbc24
resolver
uniprot
A0A1L1SV84
resolver
uniprot
Q3TIF5
resolver
uniprot
Q8CD13
resolver
uniprot_entry
A0A1L1SV84_MOUSE
resolver
uniprot_entry
SPC24_MOUSE
resolver
uniprot_sec
Q3TIF5
resolver
uniprot_sec
Q8CD13
resolver
amino_acid_sequence
MAAFRDMVEVSNWLLSLLGANRAEAQQRRLLGSYEQMMERLLEMQDGAYRQLRETLAVEEEVAQSLLELKECTRQGDTELQQLEVELQRTSKEDTCVQARLRQLITELQELREMEEELQRQERDVDEDNTVTIPSAVYVAHLYHQISKIQWDYECEPGMIKGIHHGPTVAQPIHLDSAQLSPKFISDYLWSLVDTTWEPEP
uniprot
proteins
function
FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. {ECO:0000250|UniProtKB:Q8NBT2}.
uniprot
proteins
mass_dalton
23416
uniprot
proteins
protein_family
SPC24 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8NBT2}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q8NBT2}. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. {ECO:0000250|UniProtKB:Q8NBT2}.
uniprot
proteins