Ost4
entrez
67695
canonical
uniprot
Q99LX8
canonical
ensembl
ENSMUSG00000038803
resolver
ensp
ENSMUSP00000126221
resolver
ensp
ENSMUSP00000128352
resolver
ensp
ENSMUSP00000333999
resolver
enst
ENSMUST00000132034
resolver
enst
ENSMUST00000132253
resolver
genesymbol
Ost4
resolver
uniprot_entry
OST4_MOUSE
resolver
amino_acid_sequence
MITDVQLAIFANMLGVSLFLLVVLYHYVAVNNPKKQE
uniprot
proteins
function
FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Specifically involved in maintaining stability of STT3A-containing OST complexes. {ECO:0000250|UniProtKB:P0C6T2}.
uniprot
proteins
mass_dalton
4193
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:P0C6T2}.
uniprot
proteins
protein_family
OST4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
37
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:P0C6T2}. Endoplasmic reticulum membrane; Single-pass type III membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins