IQUB
entrez
154865
canonical
uniprot
Q8NA54
canonical
ensembl
ENSG00000164675
resolver
ensp
ENSP00000324882
resolver
ensp
ENSP00000417769
resolver
ensp
ENSP00000588306
resolver
genesymbol
IQUB
resolver
hgnc
HGNC:21995
resolver
uniprot
A4D0X0
resolver
uniprot
Q49AL6
resolver
uniprot
Q4G189
resolver
uniprot
Q5BJD9
resolver
uniprot
Q6NUH6
resolver
uniprot
Q8N9Y2
resolver
uniprot_entry
IQUB_HUMAN
resolver
uniprot_sec
A4D0X0
resolver
uniprot_sec
Q49AL6
resolver
uniprot_sec
Q4G189
resolver
uniprot_sec
Q5BJD9
resolver
uniprot_sec
Q6NUH6
resolver
uniprot_sec
Q8N9Y2
resolver
amino_acid_sequence
MSNQQEKYEAQNIVNSTEESDDAFDTVTIPVPSEEPQESDQTEEHESGIEQFSESHAIHVEEQSDQSFSSLEPDNEQLMEEVISPRQVSYTPQHHEKQYAMQRPNDDSLAFLDKIKSVKESLQESVEDSLATVKVVLIPVGQEIVIPFKVDTILKYLKDHFSHLLGIPHSVLQIRYSGKILKNNETLVQHGVKPQEIVQVEIFSTNPDLYPVRRIDGLTDVSQIITVTVQTGLDQYQQVPVEIVKSDFHKPFLGGFRHKVTGVEYHNAGTQTVPKRIPERLSIFCRDTQTVFQKKNLQQTTNTTSTQMTNIGVYVSNMTDKLVTPGKYFSAAEYHAQRLKAVIVIQTYYRQWHAKIFVENLRRQKSLRLEWETQQELRKIREKEEWIKLDYHRRHNPKTNEDFEFLYNALEFWRQEELTRINQSFTGAERKAALCELLEKETQIIASIGRHRYIAYMANQEAAIQAFLDKCSAPKIWRTPNGKTIEMDTQFTIRARELQNIYKCIMLKNISQDERLDVLLTLKHTVKEHECKLTQEILELIDREVDLMMRGVKHHNLEGLRKRIATLFFHYIKTPLFNPEVAKYLKVPQDPLKFYKKIYFCHSCQLYLPSTEFSVSSTSRRIYRCRNCINLQNEAQKRESFLKYKCLLQQLYYTEADYEDDSKIAFLMQLQDIQYLTENIWASQSVLSACDNLSDLVMVRWNKSLEWSPWNCILLTKDEAAAHLKLTSIEEGYERSFIHKIKHKHILAKNYFSQVPVLASFILDDGEIDEIRWKYHSDTTPKIIESQRPPH
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in IQUB may be the cause of spermatogenic failure with radial spoke defects, leading to asthenospermia and male infertility (PubMed:36355624). Sperm appear largely normal morphologically but with radial spoke defects, and their motility is severely reduced (PubMed:36355624). {ECO:0000269|PubMed:36355624}.
uniprot
proteins
function
FUNCTION: Adapter protein that anchors the radial spoke 1 (RS1) complex to the A microtubule of outer doublet microtubules in axonemes (PubMed:36355624). The triple radial spokes (RS1, RS2 and RS3) are required to modulate beating of the sperm flagellum (PubMed:36355624). May play a role in inhibiting signaling via MAPK1/ERK2 and MAPK3/ERK1 (PubMed:36355624). Additionally, may play a role in the functioning of cilia (By similarity). Not required for the functioning of tracheal or ependymal cilia (By similarity). {ECO:0000250|UniProtKB:Q8CDK3, ECO:0000269|PubMed:36355624}.
uniprot
proteins
mass_dalton
92581
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
29601588
uniprot
proteins
pubmed
36355624
uniprot
proteins
sequence_length
791
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q8CDK3}. Cell projection, cilium {ECO:0000250|UniProtKB:Q8CDK3}. Note=Localizes to the axoneme of sperm cells and the cilia of tracheal epithelial cells. {ECO:0000250|UniProtKB:Q8CDK3}.
uniprot
proteins