CMKLR2
entrez
2825
canonical
uniprot
P46091
canonical
ensembl
ENSG00000183671
resolver
ensembl
ENSG00000283448
resolver
ensp
ENSP00000384345
resolver
ensp
ENSP00000397535
resolver
ensp
ENSP00000483003
resolver
ensp
ENSP00000489673
resolver
ensp
ENSP00000489693
resolver
ensp
ENSP00000490813
resolver
enst
ENST00000407325
resolver
enst
ENST00000437420
resolver
enst
ENST00000621141
resolver
enst
ENST00000636284
resolver
enst
ENST00000637075
resolver
enst
ENST00000638116
resolver
genesymbol
CMKLR2
resolver
genesymbol_syn
GPR1
resolver
hgnc
HGNC:4463
resolver
uniprot
A5JUU6
resolver
uniprot
A8K4L1
resolver
uniprot
Q53TR9
resolver
uniprot
Q6NVX4
resolver
uniprot_entry
CML2_HUMAN
resolver
uniprot_sec
A5JUU6
resolver
uniprot_sec
A8K4L1
resolver
uniprot_sec
Q53TR9
resolver
uniprot_sec
Q6NVX4
resolver
amino_acid_sequence
MEDLEETLFEEFENYSYDLDYYSLESDLEEKVQLGVVHWVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFRSSVAEILKYTLWEVSCSGTVSEQLRNSETKNLCLLETAQ
uniprot
proteins
function
FUNCTION: Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:18165312, PubMed:27716822). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too (PubMed:27716822). Also acts as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q8K087, ECO:0000269|PubMed:18165312, ECO:0000269|PubMed:27716822}.; FUNCTION: (Microbial infection) Coreceptor for HIV-1. {ECO:0000269|PubMed:10233994}.
uniprot
proteins
mass_dalton
41431
uniprot
proteins
protein_family
Chemokine-like receptor (CMKLR) family
uniprot
proteins
pubmed
10233994
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
18165312
uniprot
proteins
pubmed
27716822
uniprot
proteins
pubmed
29279348
uniprot
proteins
pubmed
7851889
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27716822}; Multi-pass membrane protein {ECO:0000255}. Note=Internalizes in presence of its ligand, TAFA1 (By similarity). Internalizes efficiently in response to RARRES2 (PubMed:27716822). {ECO:0000250|UniProtKB:Q8K087, ECO:0000269|PubMed:27716822}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..62; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 74..94; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 211..231; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 248..268; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 287..307; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins