Pdcd4
entrez
64031
canonical
uniprot
Q9JID1
canonical
ensembl
ENSRNOG00000014779
resolver
ensembl
ENSRNOG00055028744
resolver
ensembl
ENSRNOG00060016895
resolver
ensembl
ENSRNOG00065010846
resolver
ensp
ENSRNOP00000020155
resolver
ensp
ENSRNOP00000076366
resolver
genesymbol
Pdcd4
resolver
genesymbol_syn
Dug
resolver
uniprot
B3DM93
resolver
uniprot_entry
B3DM93_RAT
resolver
uniprot_entry
PDCD4_RAT
resolver
amino_acid_sequence
MDVENEQILNVNPTDPDNLSDSLFSGDEENAGTEEIKNEINGNWISASTINEARINAKAKRRLRKNSSRDSGRGDSVSDNGSEAVRSGVAVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLDETAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTNDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQPVNHLVKEIDMLLKEYLLSGDMSEAEHCLKELEVPHFHHELVYEAIVMVLESTGESAFKMMLDLLKSLWKSSTITIDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY
uniprot
proteins
function
FUNCTION: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:12220511}.
uniprot
proteins
mass_dalton
51736
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation (By similarity). {ECO:0000250}.; PTM: Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4. {ECO:0000250}.
uniprot
proteins
protein_family
PDCD4 family
uniprot
proteins
pubmed
12220511
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (By similarity). {ECO:0000250}.
uniprot
proteins