Aimp2
entrez
288480
canonical
uniprot
Q32PX2
canonical
ensembl
ENSRNOG00000001044
resolver
ensembl
ENSRNOG00055011408
resolver
ensembl
ENSRNOG00060027684
resolver
ensp
ENSRNOP00000001379
resolver
ensp
ENSRNOP00055015597
resolver
ensp
ENSRNOP00060040004
resolver
enst
ENSRNOT00000001379
resolver
enst
ENSRNOT00055019358
resolver
enst
ENSRNOT00060048069
resolver
genesymbol
Aimp2
resolver
genesymbol_syn
Jtv1
resolver
uniprot_entry
AIMP2_RAT
resolver
amino_acid_sequence
MPMYQVKPYHGGSAPLRVELPTCMYRLPNVHSKTTSPATDAGHVQEPSEPSLRALESRQDDILKRLYELKAAVDGLSKMIHTPDADLDVTNILQADEPTTLTTNALDLNSVLGKDYGALKDIVINANPASPPLSLLVLHRLLCERYRVLSTVHTHSSVKNVPENLLKCFGEQARKQSRHEYQLGFTLIWKNVPKTQMKFSVQTMCPIEGEGNIARFLFSLFGQKHNAVHLTLIDSWVDIAMFQLREGSSKEKAAVFRSMNSALGKSPWLVGNELTVADVVLWSVLQQTGGSSGAAPTNVQRWLKSCENLAPFSTALQLLK
uniprot
proteins
function
FUNCTION: Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. {ECO:0000250|UniProtKB:Q13155}.
uniprot
proteins
mass_dalton
35443
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues in response to UV irradiation. {ECO:0000250}.; PTM: Ubiquitinated by PRKN, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8R010}. Nucleus {ECO:0000250|UniProtKB:Q8R010}. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. {ECO:0000250|UniProtKB:Q8R010}.
uniprot
proteins