Apex2
entrez
77622
canonical
uniprot
Q68G58
canonical
ensembl
ENSMUSG00000025269
resolver
ensp
ENSMUSP00000026303
resolver
ensp
ENSMUSP00000108339
resolver
ensp
ENSMUSP00000108340
resolver
ensp
ENSMUSP00000333464
resolver
enst
ENSMUST00000026303
resolver
enst
ENSMUST00000112720
resolver
genesymbol
Apex2
resolver
genesymbol_syn
Ape2
resolver
uniprot
A2AFM3
resolver
uniprot
Q8BJP7
resolver
uniprot
Q8BTR7
resolver
uniprot
Q8BUZ2
resolver
uniprot
Q8BYE9
resolver
uniprot
Q8R018
resolver
uniprot
Q8R328
resolver
uniprot
Q9CS12
resolver
uniprot_entry
A2AFM3_MOUSE
resolver
uniprot_entry
APEX2_MOUSE
resolver
uniprot_sec
Q8BJP7
resolver
uniprot_sec
Q8BTR7
resolver
uniprot_sec
Q8BUZ2
resolver
uniprot_sec
Q8BYE9
resolver
uniprot_sec
Q8R018
resolver
uniprot_sec
Q8R328
resolver
uniprot_sec
Q9CS12
resolver
activity_regulation
ACTIVITY REGULATION: 3'-5' exonuclease activity is activated by sodium and manganese (By similarity). 3'-5' exonuclease and 3'-phosphodiesterase activities are stimulated in presence of PCNA (By similarity). {ECO:0000250|UniProtKB:Q9UBZ4}.
uniprot
proteins
amino_acid_sequence
MLRVVSWNINGIRSPLQGLACQEPSSCPTALRRVLDELDADIVCLQETKVTRDVLTEPLAIVEGYNSYFSFSRSRSGYSGVATFCKDSATPVAAEEGLSGVFATLNGDIGCYGNMDEFTQEELRVLDSEGRALLTQHKIRTLEGKEKTLTLINVYCPHADPGKPERLTFKMRFYRLLQMRAEALLAAGSHVIILGDLNTAHRPIDHCDASSLECFEEDPGRKWMDGLLSNPGDEAGPHIGLFMDSYRYLHPKQQRAFTCWSVVSGARHLNYGSRLDYVLGDRALVIDTFQASFLLPEVMGSDHCPVGAVLNVSCVPAKQCPALCTRFLPEFAGTQLKILRFLVPLEQEPVREQQVLQPSHQIQAQRQPRKACMHSTRLRKSQGGPKRKQKNLMSYFQPSSSLSQTSGVELPTLPLVGPLTTPKTAEEVATATVLEEKNKVPESKDEKGERTAFWKSMLSGPSPMPLCGGHREPCVMRTVKKTGPNFGRQFYMCARPRGPPSDPSSRCNFFLWSRPS
uniprot
proteins
ec_number
3.1.11.2
uniprot
proteins
function
FUNCTION: Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (By similarity). Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends (By similarity). Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially (By similarity). Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway (By similarity). Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (By similarity). Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (PubMed:18025127, PubMed:19556307). Required for proper cell cycle progression during proliferation of peripheral lymphocytes (PubMed:15319281). {ECO:0000250|UniProtKB:Q9UBZ4, ECO:0000269|PubMed:12573260, ECO:0000269|PubMed:15319281, ECO:0000269|PubMed:18025127, ECO:0000269|PubMed:19556307}.
uniprot
proteins
mass_dalton
57340
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the CUL9-RBX1 complex. Ubiquitinated by MKRN3 at Lys-370 leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q9UBZ4}.
uniprot
proteins
protein_family
DNA repair enzymes AP/ExoA family
uniprot
proteins
pubmed
12573260
uniprot
proteins
pubmed
15319281
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18025127
uniprot
proteins
pubmed
19556307
uniprot
proteins
sequence_length
516
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12573260}. Cytoplasm {ECO:0000269|PubMed:12573260}. Mitochondrion {ECO:0000269|PubMed:12573260}. Note=Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. {ECO:0000250|UniProtKB:Q9UBZ4}.
uniprot
proteins