LACTB2
entrez
51110
canonical
uniprot
Q53H82
canonical
ensembl
ENSG00000147592
resolver
ensp
ENSP00000276590
resolver
ensp
ENSP00000428801
resolver
ensp
ENSP00000549388
resolver
ensp
ENSP00000549389
resolver
enst
ENST00000276590
resolver
enst
ENST00000522447
resolver
enst
ENST00000879329
resolver
enst
ENST00000879330
resolver
genesymbol
LACTB2
resolver
hgnc
HGNC:18512
resolver
uniprot
A0A024R811
resolver
uniprot
A8K2D6
resolver
uniprot
Q9Y392
resolver
uniprot_entry
A0A024R811_HUMAN
resolver
uniprot_entry
LACB2_HUMAN
resolver
uniprot_sec
A8K2D6
resolver
uniprot_sec
Q9Y392
resolver
amino_acid_sequence
MAAVLQRVERLSNRVVRVLGCNPGPMTLQGTNTYLVGTGPRRILIDTGEPAIPEYISCLKQALTEFNTAIQEIVVTHWHRDHSGGIGDICKSINNDTTYCIKKLPRNPQREEIIGNGEQQYVYLKDGDVIKTEGATLRVLYTPGHTDDHMALLLEEENAIFSGDCILGEGTTVFEDLYDYMNSLKELLKIKADIIYPGHGPVIHNAEAKIQQYISHRNIREQQILTLFRENFEKSFTVMELVKIIYKNTPENLHEMAKHNLLLHLKKLEKEGKIFSNTDPDKKWKAHL
uniprot
proteins
ec_number
3.1.27.-
uniprot
proteins
function
FUNCTION: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. {ECO:0000269|PubMed:26826708}.
uniprot
proteins
mass_dalton
32806
uniprot
proteins
mutagenesis
MUTAGEN 77..82; /note="Missing: Loss of endoribonuclease activity."; /evidence="ECO:0000269|PubMed:26826708"; MUTAGEN 81; /note="D->A: Loss of endoribonuclease activity."; /evidence="ECO:0000269|PubMed:26826708"; MUTAGEN 110; /note="R->A: Mildly decreases endoribonuclease activity. No effect on RNA-binding."; /evidence="ECO:0000269|PubMed:26826708"; MUTAGEN 116; /note="N->A: Loss of endoribonuclease activity. No effect on RNA-binding."; /evidence="ECO:0000269|PubMed:26826708"; MUTAGEN 118; /note="E->A: Loss of endoribonuclease activity. No effect on RNA-binding."; /evidence="ECO:0000269|PubMed:26826708"; MUTAGEN 164; /note="D->A: Loss of endoribonuclease activity."; /evidence="ECO:0000269|PubMed:26826708"; MUTAGEN 216..217; /note="HR->AT: Loss of endoribonuclease activity. Strongly decreases RNA-binding."; /evidence="ECO:0000269|PubMed:26826708"; MUTAGEN 220; /note="R->T: Loss of endoribonuclease activity. Strongly decreases RNA-binding."; /evidence="ECO:0000269|PubMed:26826708
uniprot
proteins
protein_family
Glyoxalase II family
uniprot
proteins
protein_family
Metallo-beta-lactamase superfamily
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26826708
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:26826708}.
uniprot
proteins