Agbl4
entrez
78933
canonical
uniprot
Q09LZ8
canonical
ensembl
ENSMUSG00000061298
resolver
ensp
ENSMUSP00000079568
resolver
ensp
ENSMUSP00000095533
resolver
genesymbol
Agbl4
resolver
genesymbol_syn
Ccp6
resolver
uniprot
A2A979
resolver
uniprot
A6PWC5
resolver
uniprot
A6PWC6
resolver
uniprot
E4W7Y4
resolver
uniprot
Q09LZ9
resolver
uniprot_entry
CBPC6_MOUSE
resolver
uniprot_entry
E4W7Y4_MOUSE
resolver
uniprot_sec
A2A979
resolver
uniprot_sec
A6PWC5
resolver
uniprot_sec
A6PWC6
resolver
uniprot_sec
Q09LZ9
resolver
amino_acid_sequence
MAERSQTAPEAGNDTGNEDAIGGNVNKYIVLPNGYSGQPKKGHLTFDACFESGNLGRVEQVSDFEYDLFIRPDTCNPRFRVWFNFTVENVKELQRVIFNIVNFSKTKSLYRDGMAPMVKSTSRPKWQRLPPKNVYYYRCPDHRKNYVMSFAFCFDREDDIYQFAYCYPYTYTRFQHYLDSLQKKNMDYFFREQLGQSVQQRQLDLLTITSPENLREGSEKKVIFITGRVHPGETPSSFVCQGIIDFLVSQHPIARVLREHLVFKIAPMLNPDGVYLGNYRCSLMGFDLNRHWLDPSPWAHPTLHGVKQLIIKMYNDPKTSLEFYIDIHAHSTMMNGFMYGNIFEDEERFQRQSIFPKLLCQNAEDFSYTSTSFNRDAVKAGTGRRFLGGLLDHSSYCYTLEVSFYSYIIGGTTAAVPYTEEAYMKLGRNVARTFLDYYRLNSLVEKIAVPMPRLRSKEERRLGWEHPSCLRAEQPLEVLGIPMCSGKALNEHLGNDIQWHLDCGSSTLPLGLISCSPSSSASWNDMAMSNSILLPDHSFH
uniprot
proteins
ec_number
3.4.17.-
uniprot
proteins
ec_number
3.4.17.24
uniprot
proteins
function
FUNCTION: Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:21074048, PubMed:25103237, PubMed:26829768, PubMed:29593216). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein (PubMed:21074048, PubMed:25103237). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:25103237). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK (PubMed:21074048). Mediates the deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation (PubMed:26829768). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216). {ECO:0000269|PubMed:21074048, ECO:0000269|PubMed:25103237, ECO:0000269|PubMed:26829768, ECO:0000269|PubMed:29593216}.
uniprot
proteins
mass_dalton
62210
uniprot
proteins
mutagenesis
MUTAGEN 230; /note="H->S: Abolishes deglutamylase activity; when associated with Q-233."; /evidence="ECO:0000269|PubMed:21074048, ECO:0000269|PubMed:26829768"; MUTAGEN 233; /note="E->Q: Abolishes deglutamylase activity; when associated with S-230."; /evidence="ECO:0000269|PubMed:21074048, ECO:0000269|PubMed:26829768
uniprot
proteins
protein_family
Peptidase M14 family
uniprot
proteins
pubmed
17244818
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21074048
uniprot
proteins
pubmed
25103237
uniprot
proteins
pubmed
26829768
uniprot
proteins
pubmed
29593216
uniprot
proteins
sequence_length
540
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17244818}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q5VU57}. Golgi apparatus {ECO:0000250|UniProtKB:Q5VU57}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q5VU57}. Note=Colocalizes with gamma-tubulin in the centrioles at interphase and dividing cells and with glutamylated tubulin in basal bodies of ciliated cells. {ECO:0000250|UniProtKB:Q5VU57}.
uniprot
proteins