Sirt3
entrez
64384
canonical
uniprot
Q8R104
canonical
ensembl
ENSMUSG00000025486
resolver
ensp
ENSMUSP00000026559
resolver
ensp
ENSMUSP00000101663
resolver
ensp
ENSMUSP00000271161
resolver
genesymbol
Sirt3
resolver
genesymbol_syn
Sir2l3
resolver
uniprot
B9W0A9
resolver
uniprot
C6ZII7
resolver
uniprot
Q4FJK3
resolver
uniprot
Q9EPA8
resolver
uniprot_entry
Q4FJK3_MOUSE
resolver
uniprot_entry
SIR3_MOUSE
resolver
uniprot_sec
B9W0A9
resolver
uniprot_sec
C6ZII7
resolver
uniprot_sec
Q9EPA8
resolver
amino_acid_sequence
MALDPLGAVVLQSIMALSGRLALAALRLWGPGGGRRPISLCVGASGGFGGGGSSEKKFSLQDVAELLRTRACSRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYPGHYRPNVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDIWADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHMADFALADLLLILGTSLEVEPFASLSEAVQKSVPRLLINRDLVGPFVLSPRRKDVVQLGDVVHGVERLVDLLGWTQELLDLMQRERGKLDGQDR
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.286
uniprot
proteins
function
FUNCTION: NAD-dependent protein deacetylase (PubMed:17923681, PubMed:18794531, PubMed:21172655, PubMed:23835326, PubMed:26620563). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:17923681, PubMed:18794531, PubMed:21172655, PubMed:23835326). Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA, MRPL12 and the ATP synthase subunit ATP5PO (PubMed:16790548, PubMed:18794531, PubMed:21172655). Contributes to the regulation of the cellular energy metabolism (PubMed:23835326, PubMed:36804859). Important for regulating tissue-specific ATP levels (PubMed:18794531, PubMed:24252090). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301). Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (PubMed:26620563). Regulates hepatic lipogenesis (PubMed:36804859). Uses NAD(+) substrate imported by SLC25A47, triggering downstream activation of PRKAA1/AMPK-alpha signaling cascade that ultimately down-regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance (PubMed:36804859). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups, such as benzoyl and lactoyl, leading to protein debenzoylation and delactylation, respectively (By similarity). Catalyzes debenzoylation of PPIF and ACLY (By similarity). Mediates delactylation of CCNE2 and 'Lys-16' of histone H4 (H4K16la) (By similarity). {ECO:0000250|UniProtKB:Q9NTG7, ECO:0000269|PubMed:16790548, ECO:0000269|PubMed:17923681, ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:21172655, ECO:0000269|PubMed:21858060, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:23835326, ECO:0000269|PubMed:24252090, ECO:0000269|PubMed:26620563, ECO:0000269|PubMed:36804859}.
uniprot
proteins
mass_dalton
36615
uniprot
proteins
protein_family
Class I subfamily
uniprot
proteins
protein_family
Sirtuin family
uniprot
proteins
pubmed
11056054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16790548
uniprot
proteins
pubmed
17923681
uniprot
proteins
pubmed
18794531
uniprot
proteins
pubmed
19241369
uniprot
proteins
pubmed
19333382
uniprot
proteins
pubmed
21172655
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21858060
uniprot
proteins
pubmed
23283301
uniprot
proteins
pubmed
23438705
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
23835326
uniprot
proteins
pubmed
24252090
uniprot
proteins
pubmed
26620563
uniprot
proteins
pubmed
35959657
uniprot
proteins
pubmed
36804859
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform L]: Mitochondrion matrix {ECO:0000269|PubMed:19241369, ECO:0000269|PubMed:19333382, ECO:0000269|PubMed:23283301}.; SUBCELLULAR LOCATION: [Isoform S]: Cytoplasm {ECO:0000269|PubMed:11056054}.
uniprot
proteins