MOSMO
entrez
730094
canonical
uniprot
Q8NHV5
canonical
ensembl
ENSG00000185716
resolver
ensp
ENSP00000454926
resolver
genesymbol
MOSMO
resolver
genesymbol_syn
ATTHOG
resolver
genesymbol_syn
C16orf52
resolver
hgnc
HGNC:27087
resolver
uniprot
H3BNM6
resolver
uniprot_entry
MOSMO_HUMAN
resolver
uniprot_sec
H3BNM6
resolver
amino_acid_sequence
MDKLTIISGCLFLAADIFAIASIANPDWINTGESAGALTVGLVRQCQTIHGRDRTCIPPRLPPEWVTTLFFIIMGIISLTVTCGLLVASHWRREATKYARWIAFTGMILFCMAALIFPIGFYINEVGGQPYKLPNNTVVGSSYVLFVLSIFFTIVGLLFAGKVCLPG
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane. Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation. {ECO:0000250|UniProtKB:Q8C784}.
uniprot
proteins
mass_dalton
18250
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
sequence_length
167
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8C784}. Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8C784}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 68..88; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 101..121; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins