CNOT7
entrez
29883
canonical
uniprot
Q9UIV1
canonical
ensembl
ENSG00000198791
resolver
ensp
ENSP00000355279
resolver
ensp
ENSP00000429093
resolver
ensp
ENSP00000521093
resolver
ensp
ENSP00000550798
resolver
ensp
ENSP00000550800
resolver
ensp
ENSP00000601070
resolver
ensp
ENSP00000601072
resolver
ensp
ENSP00000601074
resolver
ensp
ENSP00000730504
resolver
ensp
ENSP00000730511
resolver
ensp
ENSP00000764553
resolver
ensp
ENSP00000800613
resolver
genesymbol
CNOT7
resolver
genesymbol_syn
CAF1
resolver
hgnc
HGNC:14101
resolver
uniprot
A8MZM5
resolver
uniprot
B3KMP1
resolver
uniprot
B3KN35
resolver
uniprot
D3DSP6
resolver
uniprot
G3V108
resolver
uniprot
Q7Z530
resolver
uniprot
Q96IQ6
resolver
uniprot_entry
CNOT7_HUMAN
resolver
uniprot_entry
Q96IQ6_HUMAN
resolver
uniprot_sec
A8MZM5
resolver
uniprot_sec
B3KMP1
resolver
uniprot_sec
B3KN35
resolver
uniprot_sec
D3DSP6
resolver
uniprot_sec
G3V108
resolver
uniprot_sec
Q7Z530
resolver
amino_acid_sequence
MPAATVDHSQRICEVWACNLDEEMKKIRQVIRKYNYVAMDTEFPGVVARPIGEFRSNADYQYQLLRCNVDLLKIIQLGLTFMNEQGEYPPGTSTWQFNFKFNLTEDMYAQDSIELLTTSGIQFKKHEEEGIETQYFAELLMTSGVVLCEGVKWLSFHSGYDFGYLIKILTNSNLPEEELDFFEILRLFFPVIYDVKYLMKSCKNLKGGLQEVAEQLELERIGPQHQAGSDSLLTGMAFFKMREMFFEDHIDDAKYCGHLYGLGSGSSYVQNGTGNAYEEEANKQS
uniprot
proteins
ec_number
3.1.13.4
uniprot
proteins
function
FUNCTION: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate (PubMed:19276069, PubMed:20634287, PubMed:31439799). Its function seems to be partially redundant with that of CNOT8 (PubMed:19605561). Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:19276069, PubMed:20634287, PubMed:31439799). During miRNA-mediated repression the complex also seems to act as translational repressor during translational initiation (PubMed:20065043). Additional complex functions may be a consequence of its influence on mRNA expression (PubMed:19276069, PubMed:23236473). Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity (PubMed:19276069, PubMed:23236473). {ECO:0000269|PubMed:19276069, ECO:0000269|PubMed:19605561, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:20634287, ECO:0000269|PubMed:23236473, ECO:0000269|PubMed:31439799}.
uniprot
proteins
mass_dalton
32745
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="D->N: Abolishes RNA deadenylase activity."; /evidence="ECO:0000269|PubMed:19276069"; MUTAGEN 42; /note="E->Q: Abolishes RNA deadenylase activity."; /evidence="ECO:0000269|PubMed:19276069"; MUTAGEN 138; /note="E->K: Abolishes interaction with CNOT1; when associated with Y-142 and K-149."; /evidence="ECO:0000269|PubMed:22977175"; MUTAGEN 141; /note="M->R: Abolishes interaction with CNOT1."; /evidence="ECO:0000269|PubMed:22977175"; MUTAGEN 142; /note="T->Y: Abolishes interaction with CNOT1; when associated with K-138 and K-149."; /evidence="ECO:0000269|PubMed:22977175"; MUTAGEN 149; /note="E->K: Abolishes interaction with CNOT1; when associated with K-138 and Y-142."; /evidence="ECO:0000269|PubMed:22977175"; MUTAGEN 161; /note="D->N: Abolishes RNA deadenylase activity. Drastically reduces the rate of deadenylation and decay of CBEP3-tethered mRNA."; /evidence="ECO:0000269|PubMed:19276069, ECO:0000269|PubMed:21336257"; MUTAGEN 203; /note="K->A: Abolishes interaction with TOB1."; MUTAGEN 225; /note="H->A: Abolishes RNA deadenylase activity."; /evidence="ECO:0000269|PubMed:19276069"; MUTAGEN 230; /note="D->N: Abolishes RNA deadenylase activity."; /evidence="ECO:0000269|PubMed:19276069
uniprot
proteins
protein_family
CAF1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15769875
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
19276069
uniprot
proteins
pubmed
19558367
uniprot
proteins
pubmed
19605561
uniprot
proteins
pubmed
20065043
uniprot
proteins
pubmed
20634287
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21336257
uniprot
proteins
pubmed
22977175
uniprot
proteins
pubmed
23236473
uniprot
proteins
pubmed
25106868
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30520513
uniprot
proteins
pubmed
31439799
uniprot
proteins
pubmed
32502391
uniprot
proteins
pubmed
9820826
uniprot
proteins
sequence_length
285
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9820826}. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q60809}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:31439799}. Note=NANOS2 promotes its localization to P-body (By similarity). Recruited to cytoplasmic ribonucleoprotein membraneless compartments by CAPRIN1, promoting deadenylation of mRNAs (PubMed:31439799). {ECO:0000250|UniProtKB:Q60809, ECO:0000269|PubMed:31439799}.
uniprot
proteins