Mcm3
entrez
17215
canonical
uniprot
P25206
canonical
ensembl
ENSMUSG00000041859
resolver
ensp
ENSMUSP00000059192
resolver
enst
ENSMUST00000053266
resolver
genesymbol
Mcm3
resolver
genesymbol_syn
Mcmd
resolver
genesymbol_syn
Mcmd3
resolver
uniprot
Q3UI57
resolver
uniprot
Q61492
resolver
uniprot_entry
MCM3_MOUSE
resolver
uniprot_entry
Q3UI57_MOUSE
resolver
uniprot_sec
Q61492
resolver
amino_acid_sequence
MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQNKVRELISDNQYRLIVSVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYIGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKVKPGDRIQVVGTYRCLPGKKGCYTSGTFRTVLIACNVKQMSKDIQPAFSADDIAKIKKFSKTRSKDVFEQLARSLAPSIHGHDYVKKAILCLLLGGVERELENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYRAPGEQDGDALPLGSSVDILATDDPDFTQDDQQDTRIYEKHDSLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPTLTQESAAYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKASEDESDLEDEEEKSQEDTEQKRKRRKTHAKDGESYDPYDFSEAETQMPQVHTPKTDDSQEKTDDSQETQDSQKVELSEPRLKAFKAALLEVFQEAHEQSVGMLHLTESINRNREEPFSSEEIQACLSRMQDDNQVMVSEGIVFLI
uniprot
proteins
ec_number
3.6.4.12
uniprot
proteins
function
FUNCTION: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. {ECO:0000250|UniProtKB:P25205}.
uniprot
proteins
mass_dalton
91546
uniprot
proteins
post_translational_modification
PTM: Acetylated by MCM3AP. {ECO:0000269|PubMed:10733502}.; PTM: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. {ECO:0000250|UniProtKB:P25205}.
uniprot
proteins
protein_family
MCM family
uniprot
proteins
pubmed
10733502
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1549468
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7925275
uniprot
proteins
sequence_length
812
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P25205}. Chromosome {ECO:0000250|UniProtKB:P25205}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000250|UniProtKB:P25205}.
uniprot
proteins