Pabpn1
entrez
54196
canonical
uniprot
Q8CCS6
canonical
ensembl
ENSMUSG00000022194
resolver
ensp
ENSMUSP00000022808
resolver
genesymbol
Pabpn1
resolver
genesymbol_syn
Pab2
resolver
genesymbol_syn
Pabp2
resolver
uniprot
O35935
resolver
uniprot_entry
PABP2_MOUSE
resolver
uniprot_sec
O35935
resolver
amino_acid_sequence
MAAAAAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGDPGGAGDYGNGLESEELEPGELLPEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVEADPGDGAIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSLEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRGFPRSRYRARTTNYNSSRSRFYSGFNSRPRGRIYRGRARATSWYSPY
uniprot
proteins
function
FUNCTION: Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and also controls the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (By similarity). {ECO:0000250|UniProtKB:Q28165, ECO:0000250|UniProtKB:Q86U42}.
uniprot
proteins
mass_dalton
32297
uniprot
proteins
post_translational_modification
PTM: Arginine dimethylation is asymmetric and involves PRMT1 and PRMT3. It does not influence the RNA binding properties (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22844456
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
9434149
uniprot
proteins
sequence_length
302
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86U42}. Nucleus {ECO:0000250|UniProtKB:Q86U42}. Nucleus speckle {ECO:0000250|UniProtKB:Q86U42}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus. Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism. It is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic. Nucleus; nuclear speckle (By similarity). Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity). {ECO:0000250|UniProtKB:Q28165, ECO:0000250|UniProtKB:Q86U42}.
uniprot
proteins