Nrarp
entrez
67122
canonical
uniprot
Q91ZA8
canonical
ensembl
ENSMUSG00000078202
resolver
ensp
ENSMUSP00000100615
resolver
genesymbol
Nrarp
resolver
uniprot
Q80UV7
resolver
uniprot
Q9CZM1
resolver
uniprot_entry
NRARP_MOUSE
resolver
uniprot_sec
Q80UV7
resolver
uniprot_sec
Q9CZM1
resolver
amino_acid_sequence
MSQAELSTCSAPQTQRIFQEAVRKGNTQELQSLLQNMTNCEFNVNSFGPEGQTALHQSVIDGNLELVKLLVKFGADIRLANRDGWSALHIAAFGGHQDIVLYLITKAKYAASGR
uniprot
proteins
function
FUNCTION: Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (By similarity). Involved in the regulation of canonical Wnt signaling by stabilizing LEF1 (By similarity). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and down-regulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (PubMed:21795391, PubMed:21998026). {ECO:0000250|UniProtKB:Q7T3Y0, ECO:0000250|UniProtKB:Q7Z6K4, ECO:0000269|PubMed:11783997, ECO:0000269|PubMed:19154719, ECO:0000269|PubMed:21795391, ECO:0000269|PubMed:21998026, ECO:0000305|PubMed:21998026}.
uniprot
proteins
mass_dalton
12492
uniprot
proteins
protein_family
NRARP family
uniprot
proteins
pubmed
11783997
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19154719
uniprot
proteins
pubmed
19268448
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21795391
uniprot
proteins
pubmed
21998026
uniprot
proteins
pubmed
24015274
uniprot
proteins
sequence_length
114
uniprot
proteins