SIAT4C
entrez
6484
canonical
uniprot
Q11206
canonical
ensembl
ENSG00000110080
resolver
ensp
ENSP00000227495
resolver
ensp
ENSP00000348451
resolver
ensp
ENSP00000376437
resolver
ensp
ENSP00000394354
resolver
ensp
ENSP00000433318
resolver
ensp
ENSP00000433989
resolver
ensp
ENSP00000434349
resolver
ensp
ENSP00000504548
resolver
ensp
ENSP00000530712
resolver
ensp
ENSP00000636171
resolver
ensp
ENSP00000636172
resolver
enst
ENST00000356132
resolver
enst
ENST00000677503
resolver
genesymbol
SIAT4C
resolver
genesymbol
ST3GAL4
resolver
genesymbol_syn
CGS23
resolver
genesymbol_syn
NANTA3
resolver
genesymbol_syn
SIAT4C
resolver
genesymbol_syn
ST3GAL4
resolver
genesymbol_syn
STZ
resolver
hgnc
HGNC:10864
resolver
uniprot
A0A7I2V5F3
resolver
uniprot
A0A7P0RGI5
resolver
uniprot
A8K6B2
resolver
uniprot
O60497
resolver
uniprot
Q6IBE6
resolver
uniprot
Q8N6A6
resolver
uniprot
Q8NFG7
resolver
uniprot
Q96QQ9
resolver
uniprot_entry
A0A7I2V5F3_HUMAN
resolver
uniprot_entry
A0A7P0RGI5_HUMAN
resolver
uniprot_entry
Q6IBE6_HUMAN
resolver
uniprot_entry
SIA4C_HUMAN
resolver
uniprot_sec
A8K6B2
resolver
uniprot_sec
O60497
resolver
uniprot_sec
Q8N6A6
resolver
uniprot_sec
Q8NFG7
resolver
uniprot_sec
Q96QQ9
resolver
amino_acid_sequence
MVSKSRWKLLAMLALVLVVMVWYSISREDRYIELFYFPIPEKKEPCLQGEAESKASKLFGNYSRDQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITSSSIPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQTIHYYEQITLKSMAGSGHNVSQEALAIKRMLEMGAIKNLTSF
uniprot
proteins
ec_number
2.4.3.2
uniprot
proteins
ec_number
2.4.3.4
uniprot
proteins
ec_number
2.4.3.6
uniprot
proteins
function
FUNCTION: A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:8288606, PubMed:8611500, PubMed:37632720). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8288606, PubMed:8611500). Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (By similarity). Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation (PubMed:25498912). Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (By similarity). In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively (PubMed:8288606). Metabolizes brain c-series ganglioside GT1c forming GQ1c (By similarity). Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin (PubMed:8611500). {ECO:0000250|UniProtKB:P61131, ECO:0000250|UniProtKB:Q91Y74, ECO:0000269|PubMed:25498912, ECO:0000269|PubMed:37632720, ECO:0000269|PubMed:8288606, ECO:0000269|PubMed:8611500}.
uniprot
proteins
mass_dalton
38045
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000305|PubMed:37632720, ECO:0000305|PubMed:8288606}.; PATHWAY: Glycolipid biosynthesis. {ECO:0000305|PubMed:8288606}.
uniprot
proteins
post_translational_modification
PTM: The soluble form derives from the membrane form by proteolytic processing.
uniprot
proteins
protein_family
Glycosyltransferase 29 family
uniprot
proteins
pubmed
12441665
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
25498912
uniprot
proteins
pubmed
37632720
uniprot
proteins
pubmed
7901202
uniprot
proteins
pubmed
8288606
uniprot
proteins
pubmed
8557707
uniprot
proteins
pubmed
8611500
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
uniprot
proteins
transmembrane_region
TRANSMEM 9..26; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins