NFATC1
entrez
4772
canonical
uniprot
O95644
canonical
ensembl
ENSG00000131196
resolver
ensp
ENSP00000253506
resolver
ensp
ENSP00000316553
resolver
ensp
ENSP00000327850
resolver
ensp
ENSP00000380892
resolver
ensp
ENSP00000389377
resolver
ensp
ENSP00000439992
resolver
ensp
ENSP00000442435
resolver
ensp
ENSP00000466194
resolver
ensp
ENSP00000466489
resolver
ensp
ENSP00000467181
resolver
enst
ENST00000545796
resolver
genesymbol
NFATC1
resolver
genesymbol_syn
NFAT2
resolver
genesymbol_syn
NFATC
resolver
hgnc
HGNC:7775
resolver
uniprot
A8K9C6
resolver
uniprot
B4DER8
resolver
uniprot
B5B2M4
resolver
uniprot
B5B2M5
resolver
uniprot
B5B2M6
resolver
uniprot
B5B2M7
resolver
uniprot
B5B2M8
resolver
uniprot
B5B2M9
resolver
uniprot
B5B2N1
resolver
uniprot
F5H4S8
resolver
uniprot
Q12865
resolver
uniprot
Q15793
resolver
uniprot
Q2M1S3
resolver
uniprot_entry
A8K9C6_HUMAN
resolver
uniprot_entry
B4DER8_HUMAN
resolver
uniprot_entry
F5H4S8_HUMAN
resolver
uniprot_entry
NFAC1_HUMAN
resolver
uniprot_sec
B5B2M4
resolver
uniprot_sec
B5B2M5
resolver
uniprot_sec
B5B2M6
resolver
uniprot_sec
B5B2M7
resolver
uniprot_sec
B5B2M8
resolver
uniprot_sec
B5B2M9
resolver
uniprot_sec
B5B2N1
resolver
uniprot_sec
Q12865
resolver
uniprot_sec
Q15793
resolver
uniprot_sec
Q2M1S3
resolver
amino_acid_sequence
MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEEEHYGYASSNVSPALPLPTAHSTLPAPCHNLQTSTPGIIPPADHPSGYGAALDGGPAGYFLSSGHTRPDGAPALESPRIEITSCLGLYHNNNQFFHDVEVEDVLPSSKRSPSTATLSLPSLEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRGLGACTLLGSPRHSPSTSPRASVTEESWLGARSSRPASPCNKRKYSLNGRQPPYSPHHSPTPSPHGSPRVSVTDDSWLGNTTQYTSSAIVAAINALTTDSSLDLGDGVPVKSRKTTLEQPPSVALKVEPVGEDLGSPPPPADFAPEDYSSFQHIRKGGFCDQYLAVPQHPYQWAKPKPLSPTSYMSPTLPALDWQLPSHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLMLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQRSAQELPLVEKQSTDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPVHVSFYVCNGKRKRSQYQRFTYLPANVPIIKTEPTDDYEPAPTCGPVSQGLSPLPRPYYSQQLAMPPDPSSCLVAGFPPCPQRSTLMPAAPGVSPKLHDLSPAAYTKGVASPGHCHLGLPQPAGEAPAVQDVPRPVATHPGSPGQPPPALLPQQVSAPPSSSCPPGLEHSLCPSSPSPPLPPATQEPTCLQPCSPACPPATGRPQHLPSTVRRDESPTAGPRLLPEVHEDGSPNLAPIPVTVKREPEELDQLYLDDVNEIIRNDLSSTSTHS
uniprot
proteins
function
FUNCTION: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}.
uniprot
proteins
mass_dalton
101243
uniprot
proteins
mutagenesis
MUTAGEN 169; /note="S->A: No effect on subcellular localization."; MUTAGEN 172; /note="S->A: Partial nuclear translocation."; /evidence="ECO:0000269|PubMed:10652349"; MUTAGEN 187; /note="S->A: No effect on subcellular localization."; /evidence="ECO:0000269|PubMed:10652349
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NFATC-kinase and GSK3B; phosphorylation induces NFATC1 nuclear exit and dephosphorylation by calcineurin promotes nuclear import. Phosphorylation by PKA and DYRK2 negatively modulates nuclear accumulation, and promotes subsequent phosphorylation by GSK3B or casein kinase 1. {ECO:0000269|PubMed:12351631, ECO:0000269|PubMed:16511445, ECO:0000269|PubMed:9072970}.
uniprot
proteins
pubmed
10072078
uniprot
proteins
pubmed
10089876
uniprot
proteins
pubmed
10358178
uniprot
proteins
pubmed
10652349
uniprot
proteins
pubmed
12351631
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
16511445
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18218901
uniprot
proteins
pubmed
18675896
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
8202141
uniprot
proteins
pubmed
8702849
uniprot
proteins
pubmed
8990122
uniprot
proteins
pubmed
9072970
uniprot
proteins
pubmed
9111316
uniprot
proteins
pubmed
9506523
uniprot
proteins
sequence_length
943
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16511445}. Nucleus {ECO:0000269|PubMed:16511445}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. Translocation to the nucleus is increased in the presence of calcium in pre-osteoblasts (By similarity). The subcellular localization of NFATC plays a key role in the regulation of gene transcription (PubMed:16511445). Nuclear translocation of NFATC1 is enhanced in the presence of TNFSF11. Nuclear translocation is decreased in the presence of FBN1 which can bind and sequester TNFSF11 (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:16511445}.
uniprot
proteins