Ano3
entrez
228432
canonical
uniprot
A2AHL1
canonical
ensembl
ENSMUSG00000074968
resolver
ensp
ENSMUSP00000097219
resolver
ensp
ENSMUSP00000224069
resolver
genesymbol
Ano3
resolver
genesymbol_syn
Tmem16c
resolver
uniprot
A2AHL0
resolver
uniprot_entry
ANO3_MOUSE
resolver
uniprot_sec
A2AHL0
resolver
amino_acid_sequence
MVHHSGSIQSFKQQKGMNISKSEITTEASLKPSRRSLPCLAQSYAHSKSLSQSASLFQSTESESQAPTSVTFLSADKPEHVTSEESRKDSTLKCSFADLSDFCLALGKDKDYLDESEHANYDRSRLLNDFVTKDKPASKTKLSKNDMSYIASSGLLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIANPDIMFIKIHIPWDTLCKYAERLNIRVPFRKKCYYTDQKNKSKSRVQNYFKRIKKWMSQNPMVLDKSAFPELEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLITNGSYIAAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEVINPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFVKQHWQFATSGAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVKQNENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQEMMYEAELEHLQQQRRKSGQPIHHEWP
uniprot
proteins
function
FUNCTION: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (PubMed:23532839). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:23532839). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (PubMed:23872594). {ECO:0000269|PubMed:23532839, ECO:0000269|PubMed:23872594}.
uniprot
proteins
mass_dalton
114568
uniprot
proteins
protein_family
Anoctamin family
uniprot
proteins
pubmed
18729231
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20056604
uniprot
proteins
pubmed
22302790
uniprot
proteins
pubmed
23532839
uniprot
proteins
pubmed
23872594
uniprot
proteins
sequence_length
981
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Note=Shows an intracellular localization. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 404..424; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 551..571; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 593..613; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 641..661; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 762..782; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 811..831; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 915..935; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins