NPR3
entrez
4883
canonical
uniprot
P17342
canonical
ensembl
ENSG00000113389
resolver
ensp
ENSP00000265074
resolver
ensp
ENSP00000318340
resolver
ensp
ENSP00000388408
resolver
ensp
ENSP00000398028
resolver
enst
ENST00000434067
resolver
genesymbol
NPR3
resolver
genesymbol_syn
ANPRC
resolver
genesymbol_syn
C5orf23
resolver
genesymbol_syn
NPRC
resolver
hgnc
HGNC:7945
resolver
uniprot
A2RRD1
resolver
uniprot
A8K4A5
resolver
uniprot
B4DT84
resolver
uniprot
C9JK69
resolver
uniprot
E7EPG9
resolver
uniprot_entry
A8K4A5_HUMAN
resolver
uniprot_entry
ANPRC_HUMAN
resolver
uniprot_entry
C9JK69_HUMAN
resolver
uniprot_sec
A2RRD1
resolver
uniprot_sec
B4DT84
resolver
uniprot_sec
E7EPG9
resolver
amino_acid_sequence
MPSLLVLTFSPCVLLGWALLAGGTGGGGVGGGGGGAGIGGGRQEREALPPQKIEVLVLLPQDDSYLFSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSIYSFDETKDLDLEDIVRNIQASERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNMEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGRFEMRPNVKYPWGPLKLRIDENRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRTQQEESNLGKHRELREDSIRSHFSVA
uniprot
proteins
disease_involvement
DISEASE: Boudin-Mortier syndrome (BOMOS) [MIM:619543]: An autosomal recessive disorder characterized by tall stature, long digits, and extra epiphyses in the hands and feet. In addition, some patients show joint hypermobility and dilation of the aortic root. {ECO:0000269|PubMed:30032985}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity). {ECO:0000250|UniProtKB:P70180}.
uniprot
proteins
mass_dalton
59808
uniprot
proteins
protein_family
ANF receptor family
uniprot
proteins
pubmed
11533490
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1660465
uniprot
proteins
pubmed
16870210
uniprot
proteins
pubmed
2162522
uniprot
proteins
pubmed
2169733
uniprot
proteins
pubmed
30032985
uniprot
proteins
pubmed
7727388
uniprot
proteins
sequence_length
541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30032985}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 482..504; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins