IMPA2
entrez
3613
canonical
uniprot
O14732
canonical
ensembl
ENSG00000141401
resolver
ensp
ENSP00000269159
resolver
genesymbol
IMPA2
resolver
genesymbol_syn
IMP.18P
resolver
hgnc
HGNC:6051
resolver
uniprot
B0YJ29
resolver
uniprot
Q9UJT3
resolver
uniprot_entry
IMPA2_HUMAN
resolver
uniprot_sec
B0YJ29
resolver
uniprot_sec
Q9UJT3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by high Li(+) and restricted Mg(2+) concentrations. {ECO:0000269|PubMed:17068342}.
uniprot
proteins
amino_acid_sequence
MKPSGEDQAALAAGPWEECFQAAVQLALRAGQIIRKALTEEKRVSTKTSAADLVTETDHLVEDLIISELRERFPSHRFIAEEAAASGAKCVLTHSPTWIIDPIDGTCNFVHRFPTVAVSIGFAVRQELEFGVIYHCTEERLYTGRRGRGAFCNGQRLRVSGETDLSKALVLTEIGPKRDPATLKLFLSNMERLLHAKAHGVRVIGSSTLALCHLASGAADAYYQFGLHCWDLAAATVIIREAGGIVIDTSGGPLDLMACRVVAASTREMAMLIAQALQTINYGRDDEK
uniprot
proteins
ec_number
3.1.3.25
uniprot
proteins
function
FUNCTION: Phosphatase that can use myo-inositol monophosphates, myo-inositol 1,4-diphosphate, scyllo-inositol-1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate and 2'-AMP as substrates in vitro (PubMed:17068342). It is likely that IMPA2 has an as yet unidentified in vivo substrate(s) (PubMed:17068342). Has been implicated as the pharmacological target for lithium (Li(+)) action in brain (PubMed:17068342). {ECO:0000269|PubMed:17068342}.
uniprot
proteins
mass_dalton
31321
uniprot
proteins
mutagenesis
MUTAGEN 104; /note="D->N: Loss of activity."; /evidence="ECO:0000269|PubMed:17068342
uniprot
proteins
pathway_participation
PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
uniprot
proteins
protein_family
Inositol monophosphatase superfamily
uniprot
proteins
pubmed
10822345
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15504365
uniprot
proteins
pubmed
17068342
uniprot
proteins
pubmed
17340635
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
9322233
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17068342}.
uniprot
proteins