Dhrs7b
entrez
216820
canonical
uniprot
Q99J47
canonical
ensembl
ENSMUSG00000042569
resolver
ensp
ENSMUSP00000044924
resolver
ensp
ENSMUSP00000269231
resolver
genesymbol
Dhrs7b
resolver
genesymbol_syn
Sdr32c1
resolver
genesymbol_syn
dhrs7b
resolver
uniprot
I7DM66
resolver
uniprot
Q3UNS3
resolver
uniprot
Q5NCT5
resolver
uniprot_entry
I7DM66_MOUSE
resolver
uniprot_entry
PEXRP_MOUSE
resolver
uniprot_sec
Q3UNS3
resolver
uniprot_sec
Q5NCT5
resolver
amino_acid_sequence
MISPSFRKGMLKERVMDLASQTTILPLLFGCLGIFSLFRLLQRIRSKAYLRNAVVVVTGATSGLGRECAKVFHAAGAKLVLCGRNVKALEELSRELAGSSQGQTHQPFVVTFDLADPGTIAAAAAEILQCFGYVDVLINNAGISYRGTISDTIVDVDRKVMEINYFGPVALTKALLPSMVERKQGHIVAISSIQGKISIPFRSAYSASKHATQAFFDCLRAEMEEANIKVTVISPGYIHTNLSVNAVTADGSRYGALDKNTAQGRSAAEVAQDVFDAVGKKKKDVLLTDFVPSMAVYIRTLAPGLFFRIMASRARKERKSKSS
uniprot
proteins
ec_number
1.1.1.101
uniprot
proteins
function
FUNCTION: Reductase required for adipogenesis and activation of PPARG nuclear receptor (PubMed:22863804, PubMed:28930673). Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively, synthesizing ether-linked phospholipids that act as agonists for PPARG (PubMed:22863804). Also regulates adipogenesis by preventing adipocyte browning: following import into the nucleus, interacts with PRDM16, inhibiting the interaction between PRDM16 and PPARG and preventing differentiation of brown adipocytes (PubMed:28930673). {ECO:0000269|PubMed:22863804, ECO:0000269|PubMed:28930673}.
uniprot
proteins
mass_dalton
34987
uniprot
proteins
mutagenesis
MUTAGEN 253..285; /note="Missing: Abolished localization to the nucleus."; /evidence="ECO:0000269|PubMed:28930673
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22863804
uniprot
proteins
pubmed
28930673
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:22863804, ECO:0000269|PubMed:28930673}; Single-pass type II membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5RJY4}; Single-pass type II membrane protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:28930673}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins