Ercc3
entrez
13872
canonical
uniprot
P49135
canonical
ensembl
ENSMUSG00000024382
resolver
ensp
ENSMUSP00000025241
resolver
ensp
ENSMUSP00000306588
resolver
enst
ENSMUST00000025241
resolver
genesymbol
Ercc3
resolver
genesymbol_syn
Xpb
resolver
genesymbol_syn
Xpbc
resolver
uniprot_entry
ERCC3_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Phosphorylation on Ser-752 by CK2 controls the 5'-excision activity of ERCC1-XPF endonuclease; phosphorylated protein inhibits the excision activity and thus NER. ATPase activity is stimulated by TFIIH subunit p52 (GTF2H4). DNA translocase activity by this subunit in TFIIH is stimulated by XPA, ERCC5/XPG and XFP plus ERCC1. {ECO:0000250|UniProtKB:P19447}.
uniprot
proteins
amino_acid_sequence
MGKRDRVDRDKKKSKKRQYEEEEEDEDDIPGNESQEAVPSAAGKQVDESSTKVDEYGAKDYRQQMPLKGDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIIQFIKLCTVSYGKVKLVLKHNRYFVESSHPDVIQHLLQDPVIRECRLRNAEGEATELITETFTSKSAISKTAAEGSGGPSTSQGVDAQATSDIPKDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCICLEYPLLAEYDFRNDTLNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVHTIPARMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEELAFSTKEEQQQLLQKVLAATDLDAEEEVVAGEFGSRSGQASRRCGTMSSLSGADDTVYMEYHSSRSKASSKHVHPLFKRFRK
uniprot
proteins
ec_number
5.6.2.4
uniprot
proteins
function
FUNCTION: ATP-dependent 3'-5' DNA helicase/translocase; binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex. When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting and twisting that allows XPD/ERCC2 helicase to anchor. The ATP-dependent helicase activity of XPB/ERCC3 may be required for promoter escape. Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The structure of the TFIIH transcription complex differs from the NER-TFIIH complex; large movements by XPD/ERCC2 and XPB/ERCC3 are stabilized by XPA. {ECO:0000250|UniProtKB:P19447}.
uniprot
proteins
mass_dalton
89126
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-752 by CK2 controls the 5'-excision activity of ERCC1-XPF endonuclease; phosphorylated protein inhibits the excision activity and thus NER. Dephosphorylation reactivates the 5'-excision step. Phosphorylation has no effect on transcription or the 3'-5' helicase activity. {ECO:0000250|UniProtKB:P19447}.
uniprot
proteins
protein_family
Helicase family
uniprot
proteins
protein_family
RAD25/XPB subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1747940
uniprot
proteins
sequence_length
783
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins