ERFE
entrez
151176
canonical
uniprot
Q4G0M1
canonical
ensembl
ENSG00000178752
resolver
ensp
ENSP00000442304
resolver
enst
ENST00000546354
resolver
genesymbol
ERFE
resolver
genesymbol_syn
C1QTNF15
resolver
genesymbol_syn
CTRP15
resolver
genesymbol_syn
FAM132B
resolver
hgnc
HGNC:26727
resolver
uniprot
W8S2M9
resolver
uniprot_entry
ERFE_HUMAN
resolver
uniprot_sec
W8S2M9
resolver
amino_acid_sequence
MAPARRPAGARLLLVYAGLLAAAAAGLGSPEPGAPSRSRARREPPPGNELPRGPGESRAGPAARPPEPTAERAHSVDPRDAWMLFVRQSDKGVNGKKRSRGKAKKLKFGLPGPPGPPGPQGPPGPIIPPEALLKEFQLLLKGAVRQRERAEPEPCTCGPAGPVAASLAPVSATAGEDDDDVVGDVLALLAAPLAPGPRAPRVEAAFLCRLRRDALVERRALHELGVYYLPDAEGAFRRGPGLNLTSGQYRAPVAGFYALAATLHVALGEPPRRGPPRPRDHLRLLICIQSRCQRNASLEAIMGLESSSELFTISVNGVLYLQMGQWTSVFLDNASGCSLTVRSGSHFSAVLLGV
uniprot
proteins
function
FUNCTION: Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores (PubMed:24880340, PubMed:30097509, PubMed:31800957). Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (By similarity). Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signaling (By similarity). Inhibits autophagy induced by nutrient deficiency in hepatocytes via promoting the phosphorylation of IRS1, AKT, and MTOR, and thereby subsequent activation of the AKT-MTOR signaling pathway (By similarity). Negatively regulates the differentiation of osteoblasts, potentially via sequestering BMP2, and thereby inhibits the activation of SMAD signaling (By similarity). The reduction in BMP2 signaling in osteoblasts also results in an increase in expression of the osteoclastogenesis-promoting factors TNFSF11/RANKL and SOST, thereby indirectly promotes bone resorption (By similarity). {ECO:0000250|UniProtKB:Q6PGN1, ECO:0000269|PubMed:24880340, ECO:0000269|PubMed:30097509, ECO:0000269|PubMed:31800957}.
uniprot
proteins
mass_dalton
37279
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; required for secretion of the mature protein. {ECO:0000250|UniProtKB:Q6PGN1}.
uniprot
proteins
protein_family
Adipolin/erythroferrone family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
24880340
uniprot
proteins
pubmed
30097509
uniprot
proteins
pubmed
31800957
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6PGN1}. Note=Secreted when glycosylated at Asn-243 and Asn-295 (By similarity). Hydroxylation promotes secretion (By similarity). {ECO:0000250|UniProtKB:Q6PGN1}.
uniprot
proteins