GABRP
entrez
2568
canonical
uniprot
O00591
canonical
ensembl
ENSG00000094755
resolver
ensp
ENSP00000265294
resolver
ensp
ENSP00000430100
resolver
ensp
ENSP00000430727
resolver
ensp
ENSP00000532290
resolver
enst
ENST00000265294
resolver
enst
ENST00000518525
resolver
enst
ENST00000519385
resolver
enst
ENST00000862231
resolver
genesymbol
GABRP
resolver
hgnc
HGNC:4089
resolver
uniprot
A8KA36
resolver
uniprot
B4DTP4
resolver
uniprot
D3DQL2
resolver
uniprot
E7EWG0
resolver
uniprot
Q32MJ1
resolver
uniprot_entry
B4DTP4_HUMAN
resolver
uniprot_entry
E7EWG0_HUMAN
resolver
uniprot_entry
GBRP_HUMAN
resolver
uniprot_sec
A8KA36
resolver
uniprot_sec
D3DQL2
resolver
uniprot_sec
Q32MJ1
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically potentiated by alphaxalone (PubMed:10462548). Allosterically inhibited by pregnenolone sulfate (PubMed:10462548). Inhibited by lanthanum (PubMed:10462548). High sensitivity to inhibition by zinc (PubMed:10462548). The binding of pi subunit with other GABAAR subunits alters the receptor sensitivity to modulatory agents such as pregnanolone (PubMed:9182563). {ECO:0000269|PubMed:10462548, ECO:0000269|PubMed:9182563}.
uniprot
proteins
amino_acid_sequence
MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYMYF
uniprot
proteins
function
FUNCTION: Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA) (PubMed:10462548). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10462548). Pi-containing GABAARs are mostly located in peripheral tissues. In the uterus, pi subunits modulate uterus contraction by altering the sensitivity of GABAARs to pregnanolone (PubMed:9182563). In the lungs, pi-containing GABAARs contribute to pulmonary fluid transport via luminal secretion of chloride (By similarity). {ECO:0000250|UniProtKB:O09028, ECO:0000250|UniProtKB:P47870, ECO:0000269|PubMed:10462548, ECO:0000269|PubMed:9182563}.
uniprot
proteins
mass_dalton
50640
uniprot
proteins
protein_family
GABRP sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
10462548
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
9182563
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:O09028}; Multi-pass membrane protein {ECO:0000255}. Note=Located on the apical plasma membrane of alveolar epithelial type II cells. {ECO:0000250|UniProtKB:O09028}.
uniprot
proteins
transmembrane_region
TRANSMEM 242..262; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 271..290; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 302..322; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 420..440; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins