Cep68
entrez
216543
canonical
uniprot
Q8C0D9
canonical
ensembl
ENSMUSG00000044066
resolver
ensp
ENSMUSP00000054943
resolver
genesymbol
Cep68
resolver
uniprot
Q3US49
resolver
uniprot
Q5SW85
resolver
uniprot
Q8R2V0
resolver
uniprot_entry
CEP68_MOUSE
resolver
uniprot_sec
Q3US49
resolver
uniprot_sec
Q5SW85
resolver
uniprot_sec
Q8R2V0
resolver
amino_acid_sequence
MALSEDEAEAEVSVNTKVPSCGRWNSGKLLPSGLEPDQPLHLGVEGGPLWRAEADPGCISGVFLSRVHTASKEPVADRSKPPLRGPLPSASVGTGEVLHSMGSQMEEDRLPASQDLLPALQVFGTITVCSGQEADSEDFQATLDPSQVLGLSQQPHTSGLPLPPQWKSTVSPGAPQLSSRSISASSVGSSLQDHQEKAGPQRASFANVSSPELTVPQAAHSVVGAGPPLQGSAQPLTSGSDATGLGKRHLSFQAEYWACALPNSLPPSPNRHSALWDPNKEYEDLLDYTYPLRPGPQLPKQPESHVLTEPVLQDSGVDLDSLSVSPASTLKSPTNVSHNCSSAEVPTLPFSGARESCLKRWPLGIFQKQGGTSLSSWNQLASTPRAPGTEDASWENREAALRGTAEDCLPIGEDLRMGSPQLKTKEKEPPFPRQKRGRQHVSCPACVTPGWPSEEEVGSDEEYLALPTRLTQVSSLVSYSGARPSFVNLHTGAAEEHSSLQVSDSDKPASPTLDSSHRKHPSGTSFQGPVGQNPCFRHSIQPQDSRGKSSLMSNQTLGVSSKPLKTQPASKAMTDRRLFSELVAGETLPRTTDEQEKASLVQCVQTFCCRLEELICWLYNVTDVADLSAPPRTSLTGLKSSLQLYRQFKKDVDEHQSLTESVLEKGEILLQCLLDNTPVLKDVLERIAKQSGELESRADHLYDSILASLDMLAGCTLIPDNRPTAAEHPHEGL
uniprot
proteins
function
FUNCTION: Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase. Contributes to CROCC/rootletin filament formation. {ECO:0000250|UniProtKB:Q76N32}.
uniprot
proteins
mass_dalton
78749
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PLK1 is required for binding to BTRC in prometaphase. Phosphorylated directly or indirectly by NEK2. NEK2-mediated phosphorylation promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis. {ECO:0000250|UniProtKB:Q76N32}.; PTM: Ubiquitinated and targeted for proteasomal degradation in early mitosis by the SCF(BTRC) and/or SCF(FBXW11) E3 ubiquitin-protein ligase complexes. Degradation is complete by prometaphase and is required for removal of CDK5RAP2 from the peripheral pericentriolar material and subsequent centriole separation. {ECO:0000250|UniProtKB:Q76N32}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
733
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes to thin fibers protruding away from the proximal ends of the two centrioles. Dissociates from interphase centrosomes at the onset of mitosis. {ECO:0000250|UniProtKB:Q76N32}.
uniprot
proteins