S100a1
entrez
295214
canonical
uniprot
P35467
canonical
ensembl
ENSRNOG00000012410
resolver
ensp
ENSRNOP00000017000
resolver
enst
ENSRNOT00000017000
resolver
genesymbol
S100a1
resolver
uniprot_entry
S10A1_RAT
resolver
amino_acid_sequence
MGSELETAMETLINVFHAHSGKEGDKYKLSKKELKDLLQTELSSFLDVQKDADAVDKIMKELDENGDGEVDFQEFVVLVAALTVACNNFFWENS
uniprot
proteins
function
FUNCTION: Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:18650434). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (By similarity) (PubMed:18650434). {ECO:0000250|UniProtKB:P23297, ECO:0000269|PubMed:18650434}.
uniprot
proteins
mass_dalton
10560
uniprot
proteins
post_translational_modification
PTM: Glutathionylated; glutathionylation increases affinity to calcium about 10-fold. {ECO:0000250|UniProtKB:P23297}.
uniprot
proteins
protein_family
S-100 family
uniprot
proteins
pubmed
11790100
uniprot
proteins
pubmed
16169012
uniprot
proteins
pubmed
1742602
uniprot
proteins
pubmed
18650434
uniprot
proteins
pubmed
19452629
uniprot
proteins
pubmed
19910580
uniprot
proteins
sequence_length
94
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P23297}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:P23297}. Mitochondrion {ECO:0000250|UniProtKB:P56565}.
uniprot
proteins