Kcnc1
entrez
16502
canonical
uniprot
P15388
canonical
ensembl
ENSMUSG00000058975
resolver
ensp
ENSMUSP00000025202
resolver
ensp
ENSMUSP00000124938
resolver
ensp
ENSMUSP00000270729
resolver
ensp
ENSMUSP00000270731
resolver
ensp
ENSMUSP00000270733
resolver
genesymbol
Kcnc1
resolver
uniprot
E9PVV3
resolver
uniprot
Q3TR92
resolver
uniprot
Q3UHB6
resolver
uniprot_entry
KCNC1_MOUSE
resolver
uniprot_entry
Q3TR92_MOUSE
resolver
uniprot_entry
Q3UHB6_MOUSE
resolver
uniprot_sec
E9PVV3
resolver
amino_acid_sequence
MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRAGRKPLRGMSI
uniprot
proteins
function
FUNCTION: Voltage-gated potassium channel that opens in response to the voltage difference across the membrane and through which potassium ions pass in accordance with their electrochemical gradient (PubMed:1400413, PubMed:2599109). The mechanism is time-dependent and inactivation is slow (PubMed:2599109). Plays an important role in the rapid repolarization of fast-firing brain neurons. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons (By similarity). {ECO:0000250|UniProtKB:P25122, ECO:0000269|PubMed:1400413, ECO:0000269|PubMed:2599109}.
uniprot
proteins
mass_dalton
57928
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; contains sialylated glycans. {ECO:0000250|UniProtKB:P25122}.
uniprot
proteins
protein_family
C (Shaw) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv3.1/KCNC1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
11517255
uniprot
proteins
pubmed
1400413
uniprot
proteins
pubmed
15217387
uniprot
proteins
pubmed
16923152
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2599109
uniprot
proteins
pubmed
9037088
uniprot
proteins
sequence_length
511
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1400413, ECO:0000269|PubMed:2599109}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P25122}. Presynaptic cell membrane {ECO:0000250|UniProtKB:P25122}. Note=Localizes in parallel fiber membranes, distributed on the perisynaptic and extrasynaptic membranes away from the active zones. {ECO:0000250|UniProtKB:P25122}.
uniprot
proteins
transmembrane_region
TRANSMEM 191..209; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 248..267; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 277..295; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 309..331; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 345..366; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 415..436; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins