Fbll1
entrez
237730
canonical
uniprot
Q80WS3
canonical
ensembl
ENSMUSG00000051062
resolver
ensp
ENSMUSP00000128889
resolver
enst
ENSMUST00000160726
resolver
genesymbol
Fbll1
resolver
uniprot_entry
FBLL1_MOUSE
resolver
amino_acid_sequence
MKPAGGRGGWGWGGGKGGSKGGDTGSGTKGGFGARTRGSSGGGRGRGRGGGGGGGGGGGDRQRRGGPGKNKNRRKKGITVSVEPHRHEGVFIYRGAEDALVTLNMVPGVSVYGEKRVTVMENGEKQEYRTWNPFRSKLAAAILGGVDQIHIKPKSKVLYLGAASGTTVSHVSDIIGPDGLVYAVEFSHRAGRDLVNVAKKRTNIIPVLEDARHPLKYRMLIGMVDVIFADVAQPDQSRIVALNAHTFLRNGGHFLISIKANCIDSTASAEAVFASEVRKLQQENLKPQEQLTLEPYERDHAVVVGVYRPPPKSK
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent RNA methyltransferase that catalyzes 2'-hydroxyl ribose methylation in RNAs (PubMed:39570315). Functions as part of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes, where guide snoRNAs ensure methylation specificity through base pairing with RNA substrates (PubMed:39570315). Exhibits broad substrate specificity, methylating multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) depending on the guide snoRNA incorporated in the complex (PubMed:39570315). Specifically expressed in brain, it regulates the expression of GAP43 by stabilizing its mRNA through methylation and thereby plays an indirect role in neuronal differentiation (PubMed:39570315). {ECO:0000269|PubMed:39570315}.
uniprot
proteins
mass_dalton
33339
uniprot
proteins
protein_family
Fibrillarin family
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
39570315
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:A6NHQ2}.
uniprot
proteins