TSPYL5
entrez
85453
canonical
uniprot
Q86VY4
canonical
ensembl
ENSG00000180543
resolver
ensp
ENSP00000322802
resolver
enst
ENST00000322128
resolver
genesymbol
TSPYL5
resolver
genesymbol_syn
KIAA1750
resolver
hgnc
HGNC:29367
resolver
uniprot
B3KRF0
resolver
uniprot
Q9C0B3
resolver
uniprot_entry
TSYL5_HUMAN
resolver
uniprot_sec
B3KRF0
resolver
uniprot_sec
Q9C0B3
resolver
amino_acid_sequence
MSGRSRGRKSSRAKNRGKGRAKARVRPAPDDAPRDPDPSQYQSLGEDTQAAQVQAGAGWGGLEAAASAQLLRLGEEAACRLPLDCGLALRARAAGDHGQAAARPGPGKAASLSERLAADTVFVGTAGTVGRPKNAPRVGNRRGPAGKKAPETCSTAGRGPQVIAGGRQKKGAAGENTSVSAGEEKKEERDAGSGPPATEGSMDTLENVQLKLENMNAQADRAYLRLSRKFGQLRLQHLERRNHLIQNIPGFWGQAFQNHPQLASFLNSQEKEVLSYLNSLEVEELGLARLGYKIKFYFDRNPYFQNKVLIKEYGCGPSGQVVSRSTPIQWLPGHDLQSLSQGNPENNRSFFGWFSNHSSIESDKIVEIINEELWPNPLQFYLLSEGARVEKGKEKEGRQGPGKQPMETTQPGVSQSN
uniprot
proteins
function
FUNCTION: Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7. {ECO:0000269|PubMed:20079711, ECO:0000269|PubMed:21170034}.
uniprot
proteins
mass_dalton
45143
uniprot
proteins
protein_family
Nucleosome assembly protein (NAP) family
uniprot
proteins
pubmed
11214970
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20079711
uniprot
proteins
pubmed
21170034
uniprot
proteins
pubmed
21269460
uniprot
proteins
sequence_length
417
uniprot
proteins