MAN1A2
entrez
10905
canonical
uniprot
O60476
canonical
ensembl
ENSG00000198162
resolver
ensp
ENSP00000348959
resolver
ensp
ENSP00000796176
resolver
enst
ENST00000356554
resolver
genesymbol
MAN1A2
resolver
genesymbol_syn
MAN1B
resolver
hgnc
HGNC:6822
resolver
uniprot
Q9H510
resolver
uniprot_entry
MA1A2_HUMAN
resolver
uniprot_sec
Q9H510
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by both 1-deoxymannojirimycin and kifunensine.
uniprot
proteins
amino_acid_sequence
MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKRFDLGLEDVLIPHVDAGKGAKNPGVFLIHGPDEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIREKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYKKVMHIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDHEARKMYDDAIEAIEKHLIKKSRGGLTFIGEWKNGHLEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAETLKYLYLLFSGDDLLPLDHWVFNTEAHPLPVLHLANTTLSGNPAVR
uniprot
proteins
ec_number
3.2.1.113
uniprot
proteins
function
FUNCTION: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
uniprot
proteins
mass_dalton
73004
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:P32906}.
uniprot
proteins
protein_family
Glycosyl hydrolase 47 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
9592125
uniprot
proteins
sequence_length
641
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 37..57; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins