Ccl2
entrez
24770
canonical
uniprot
P14844
canonical
ensembl
ENSRNOG00000007159
resolver
ensembl
ENSRNOG00055025618
resolver
ensembl
ENSRNOG00060019323
resolver
ensembl
ENSRNOG00065019591
resolver
ensp
ENSRNOP00000009448
resolver
ensp
ENSRNOP00055036150
resolver
ensp
ENSRNOP00060027325
resolver
ensp
ENSRNOP00065026364
resolver
enst
ENSRNOT00000009448
resolver
enst
ENSRNOT00055044192
resolver
enst
ENSRNOT00060033398
resolver
enst
ENSRNOT00065032989
resolver
genesymbol
Ccl2
resolver
genesymbol_syn
Je
resolver
genesymbol_syn
Mcp1
resolver
genesymbol_syn
Scya2
resolver
uniprot
Q549R5
resolver
uniprot_entry
CCL2_RAT
resolver
uniprot_sec
Q549R5
resolver
amino_acid_sequence
MQVSVTLLGLLFTVAACSIHVLSQPDAVNAPLTCCYSFTGKMIPMSRLENYKRITSSRCPKEAVVFVTKLKREICADPNKEWVQKYIRKLDQNQVRSETTVFYKIASTLRTSAPLNVNLTHKSEANASTLFSTTTSSTSVEVTSMTEN
uniprot
proteins
function
FUNCTION: Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). {ECO:0000250|UniProtKB:P10148, ECO:0000250|UniProtKB:P13500}.
uniprot
proteins
mass_dalton
16460
uniprot
proteins
post_translational_modification
PTM: Processing at the N-terminus can regulate receptor and target cell selectivity (By similarity). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (By similarity). {ECO:0000250|UniProtKB:P13500}.; PTM: N-Glycosylated. {ECO:0000250|UniProtKB:P13500}.
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
1704226
uniprot
proteins
pubmed
2106664
uniprot
proteins
pubmed
23955712
uniprot
proteins
sequence_length
148
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23955712}.
uniprot
proteins