Cmklr2
entrez
241070
canonical
uniprot
Q8K087
canonical
ensembl
ENSMUSG00000046856
resolver
ensp
ENSMUSP00000051417
resolver
enst
ENSMUST00000050536
resolver
genesymbol
Cmklr2
resolver
genesymbol_syn
Gpr1
resolver
uniprot_entry
CML2_MOUSE
resolver
amino_acid_sequence
MEVSKEMLFEELDNYSYALDYYSQESDPEEKVYLGLVHWISLFLYALAFVLGIPGNAIVIWLMGFKWKKTVTTLWFLNLAIADFIFVLFLPLYISYVALSFHWPFGLWLCKVNSFIAQLNMFSSVFFLTVISLDRYIHLLHPGLSHRHRTLKSSLVVVILVWLLASLLGGPTLYFRDTMEVNNHIICYNNFQEHELTLMRHHVLTWVKFLFGYLFPLLTMSSCYLCLIFKMKKRNILISRKHLWMILSVVIAFLVCWTPYHLFSIWELSIHHNSSFQNVLQGGIPLSTGLAFLNSCLNPILYVLISKTFQARFRASVAEVLKRSLWEASCSGTVSEQLRSAETKSLSLLETAQ
uniprot
proteins
function
FUNCTION: Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:24895415). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (PubMed:29799787). {ECO:0000269|PubMed:24895415, ECO:0000269|PubMed:29799787}.
uniprot
proteins
mass_dalton
40951
uniprot
proteins
protein_family
Chemokine-like receptor (CMKLR) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24895415
uniprot
proteins
pubmed
29799787
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29799787}; Multi-pass membrane protein {ECO:0000255}. Note=Internalizes in presence of its ligand, TAFA1 (PubMed:29799787). Internalizes efficiently in response to RARRES2 (By similarity). {ECO:0000250|UniProtKB:P46091, ECO:0000269|PubMed:29799787}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..62; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 74..94; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 211..231; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 248..268; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 287..307; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins