GOLPH3
entrez
64083
canonical
uniprot
Q9H4A6
canonical
ensembl
ENSG00000113384
resolver
ensp
ENSP00000265070
resolver
enst
ENST00000265070
resolver
genesymbol
GOLPH3
resolver
genesymbol_syn
GPP34
resolver
hgnc
HGNC:15452
resolver
uniprot
Q9UIW5
resolver
uniprot_entry
GOLP3_HUMAN
resolver
uniprot_sec
Q9UIW5
resolver
amino_acid_sequence
MTSLTQRSSGLVQRRTEASRNAADKERAAGGGAGSSEDDAQSRRDEQDDDDKGDSKETRLTLMEEVLLLGLKDREGYTSFWNDCISSGLRGCMLIELALRGRLQLEACGMRRKSLLTRKVICKSDAPTGDVLLDEALKHVKETQPPETVQNWIELLSGETWNPLKLHYQLRNVRERLAKNLVEKGVLTTEKQNFLLFDMTTHPLTNNNIKQRLIKKVQEAVLDKWVNDPHRMDRRLLALIYLAHASDVLENAFAPLLDEQYDLATKRVRQLLDLDPEVECLKANTNEVLWAVVAAFTK
uniprot
proteins
function
FUNCTION: Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. {ECO:0000269|PubMed:16263763, ECO:0000269|PubMed:19553991, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:22745132, ECO:0000269|PubMed:23027862, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:23500462}.
uniprot
proteins
mass_dalton
33811
uniprot
proteins
mutagenesis
MUTAGEN 7; /note="R->A: Altered binding to coatomer."; /evidence="ECO:0000269|PubMed:22889169"; MUTAGEN 14..15; /note="RR->AA: Loss of binding to coatomer."; /evidence="ECO:0000269|PubMed:22889169"; MUTAGEN 81; /note="W->A: Abolishes phosphoinositide binding and localization to the Golgi apparatus; when associated with A-90."; /evidence="ECO:0000269|PubMed:20026658"; MUTAGEN 90; /note="R->A: Abolishes phosphoinositide binding and localization to the Golgi apparatus; when associated with A-81."; /evidence="ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:20026658"; MUTAGEN 90; /note="R->L: Loss of function in vesicle budding, abolishes phosphoinositide binding and localization to the Golgi apparatus."; /evidence="ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:20026658"; MUTAGEN 171; /note="R->A,L: Abolishes phosphoinositide binding and localization to the Golgi apparatus; when associated with A-174."; /evidence="ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:20026658"; MUTAGEN 174; /note="R->A: Abolishes phosphoinositide binding and localization to the Golgi apparatus; when associated with A-171 or L-171."; /evidence="ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:20026658
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
GOLPH3/VPS74 family
uniprot
proteins
pubmed
11042173
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16263763
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19553991
uniprot
proteins
pubmed
19837035
uniprot
proteins
pubmed
20026658
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22745132
uniprot
proteins
pubmed
22889169
uniprot
proteins
pubmed
23027862
uniprot
proteins
pubmed
23345592
uniprot
proteins
pubmed
23500462
uniprot
proteins
pubmed
23990465
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
298
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion intermembrane space. Cell membrane {ECO:0000250}. Endosome {ECO:0000250}. Note=Phosphatidylinositol 4-phosphate-binding and oligomerization participate in the recruitment onto Golgi membranes. {ECO:0000305}.
uniprot
proteins