Dennd3
entrez
105841
canonical
uniprot
A2RT67
canonical
ensembl
ENSMUSG00000036661
resolver
ensp
ENSMUSP00000046774
resolver
enst
ENSMUST00000043414
resolver
genesymbol
Dennd3
resolver
genesymbol_syn
Kiaa0870
resolver
uniprot
B2RQ75
resolver
uniprot
Q69ZX2
resolver
uniprot
Q8C6V5
resolver
uniprot_entry
DEND3_MOUSE
resolver
uniprot_sec
B2RQ75
resolver
uniprot_sec
Q69ZX2
resolver
uniprot_sec
Q8C6V5
resolver
amino_acid_sequence
MAEPAARHLSLPSGLLELCALLGASQDSLRGLEQIAQKRGVKSASSLVPEVLSVFVPPFTTKEDGQVPGASCALGKGRRRSFRKKREKPRMEPWKSHPGDSKGPDSEDVTIPGGVDLLALPQLCFPGCVCVASEPKEDYIHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKSHWEPSVISARCFVPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDFEVDNHIKDFAARLSLIPSPPPGPLHLIFNMKPLQVVFPSRADPESPIVDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADGLVLIDIDHGSVTCSKSSDDNIDIPDVPLLLAQTFIQRVQSLQLHPDLHLAHLSASTDLNEGRARRRAWQQTLNCKIQHITLQLLVGIFREVKNHLNYEHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLNGRMDAFARMDLDTQSEEDRIDRMLISPRRPTVEKMASRKASPLHITHRRMVVSMPNLQDISLPELPPRNSSLRIMDTSNCRSSSPVLKVTPKSTYMFKIPDIHFPLESQCVQAYYTDFVTLLSKAMALLGPGDSLLLARYFYLRGLLHLMQGQLLSALLDFQNLYKTDIGIFPADLVKRTVESMSASERAQAERTPELRRLITEVFDKHGEAPKADDAVKNFELPKKHMQLNDFVKRVQESGIVKDAVIIHRLFDALTFGHEKQIDPETFRDFYTCWKETEAEAQEVSLPALLMEHLDKNECVYKLSSSVKTNRGVGKIAMTQKRLFLLTEGRPGYVEIATFRNIEEVKNSTVAFLLLRIPTLKIKTVAKKEVFEANLKSECDLWHLMVKEMWAGKQLADDHKDPQYVQQALTNVLLMDAVVGTLQSPSAIHAASKLAYFDNMKKKSPMAVPKTTSETLKHKINPSAGETAPQAIEVLLYTPGRLDPAEKVEDAHPKLWCALNEGKVVVFDASSWTVHQHCFKVGSSKVNCMVMAEHNQVWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVHNGKKPSEIYSCSLDGTVIAWNVSTLRVISRFQLSYGDLLSISLHNDRIWCCTVHKILVVTPQGFVRQELKHPKDASFLAFQLLPEEQQLWAASTGVSELYMWSLKDLDQPPQKTYLQDCSEVTCMIRVKRQIWVGGRGLSQGKTRGKIYVMDVEKVTVEKELVAHLDTVRTLCSAEDRYVLSGAGQEEGKIAIWKVE
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) activating Rab12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab12 into its active GTP-bound form. Regulates autophagy in response to starvation through Rab12 activation (PubMed:24719330, PubMed:25925668, PubMed:28249939). Starvation leads to ULK1/2-dependent phosphorylation of Ser-554 and Ser-572, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards Rab12 (PubMed:25925668). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:21718402, PubMed:24719330). Starvation also induces phosphorylation at Tyr-940, which leads to up-regulated GEF activity and initiates autophagy (PubMed:28249939). {ECO:0000269|PubMed:21718402, ECO:0000269|PubMed:24719330, ECO:0000269|PubMed:25925668, ECO:0000269|PubMed:28249939}.
uniprot
proteins
mass_dalton
143888
uniprot
proteins
mutagenesis
MUTAGEN 554; /note="S->A: Abolishes interaction with 14-3-3 proteins."; /evidence="ECO:0000269|PubMed:25925668"; MUTAGEN 572; /note="S->A: Greatly reduces interaction with 14-3-3 proteins."; /evidence="ECO:0000269|PubMed:25925668"; MUTAGEN 940; /note="Y->D: Abrogates the intramolecular linker-DENN domain interaction and enhances GEF activity towards Rab12."; /evidence="ECO:0000269|PubMed:28249939"; MUTAGEN 940; /note="Y->F: Retains the intramolecular linker-DENN domain interaction and impairs GEF activity towards Rab12."; /evidence="ECO:0000269|PubMed:28249939
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21718402
uniprot
proteins
pubmed
24719330
uniprot
proteins
pubmed
25925668
uniprot
proteins
pubmed
28249939
uniprot
proteins
sequence_length
1274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28249939}. Note=Transiently recruited to membranes to activate Rab12. {ECO:0000269|PubMed:28249939}.
uniprot
proteins