C6
entrez
12274
canonical
uniprot
E9Q6D8
canonical
ensembl
ENSMUSG00000022181
resolver
ensp
ENSMUSP00000124417
resolver
genesymbol
C6
resolver
uniprot
Q8BRY4
resolver
uniprot
Q91X70
resolver
uniprot
Q9QXT7
resolver
uniprot_entry
CO6_MOUSE
resolver
uniprot_sec
Q8BRY4
resolver
uniprot_sec
Q91X70
resolver
uniprot_sec
Q9QXT7
resolver
activity_regulation
ACTIVITY REGULATION: Membrane attack complex (MAC) assembly is inhibited by CD59, thereby protecting self-cells from damage during complement activation. MAC assembly is also inhibited by clusterin (CLU) chaperones that inhibit polymerization of C9. {ECO:0000250|UniProtKB:P13671}.
uniprot
proteins
amino_acid_sequence
MTRHLTLCFILLVMLIDKSEACFCDHYPWTHWSSCSKSCNSGTQSRQRQVVVNDYYWKNLCDKLCIKQETRECNLQTCPINCVLGDYGTWSDCDPCTEKQVKVKSVLRPSQFGGQPCTEPLVTFQPCVPSKLCKIEETNCKNKFLCDSGRCIPSKLECNGENDCGDNSDERNCGRTKPVCTRIYTPIPSVQLMGTGFHFLAGEPRGEVLDNSFTGGICKLVKTSRASNPYRVSANLENVNFEVQTIEDDLKTEFYKNLISFEKNKNEDSLSVDERTKFFPIPIFHFSEKNEHSHYSSAFNKVIKASHKKDSSFIRIHKLIKVLNFTMKATDLQLSDVFLKALVHLPLEYNSAVYSRIFDDFGTHYFTSGSLGGKYDLIYQFSRQELQNSGLTEEEAQNCVQYETKKLKFLYMEIHKEDTCTKNKLSEKYGGSFLQGSEKSISLVQGGRSQQAAALAWEKGTSGPEENVYSEWLESVKENPAVVDYKLAPITDLVRNIPCAVTKRNNLRRALQEYAAKFDPCQCAPCPNNGRPRLSGTECLCVCQSGTYGENCERRSPGYKSDAVDGNWGCWSSWSACNAAYRRSRTRECNNPAPQRGGQSCGGKDQQEEDCTVSIMENVGQPCINDDEEMKEVDLAEPEAESGCSQPPLPENAFTWNEKKLYSVGEEVEISCLTGFTAVGFQYLRCLPDRTWSQGDVECQRTSCLKPVVQDVLTISPFQRVYQIGESIELTCPRGFVVAGPSRYTCKEDSWTPPISNSLTCEQAILTKSKDLCPPGQKQSGSKCICMSPEEDCSAYSEDLCIFDGGSSQYFTSSACKFLAGKCLNNTQSHFVHSGSCQEGLQLEWGLERLKLAVNSTKRVSCGYNTCYDWENCSAHTSNCVCLLPPQCSKDENQLYCVKIGSSMREKTVNICTLGAVRCANIKVEILNPGRCPD
uniprot
proteins
function
FUNCTION: Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending. {ECO:0000250|UniProtKB:P13671}.
uniprot
proteins
mass_dalton
104624
uniprot
proteins
post_translational_modification
PTM: All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module. {ECO:0000250|UniProtKB:P13671}.
uniprot
proteins
protein_family
Complement C6/C7/C8/C9 family
uniprot
proteins
pubmed
10970092
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
934
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P13671}. Target cell membrane {ECO:0000250|UniProtKB:P13671}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P13671}. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells. {ECO:0000250|UniProtKB:P13671}.
uniprot
proteins
transmembrane_region
TRANSMEM 278..290; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:P13671"; TRANSMEM 402..415; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:P13671
uniprot
proteins