O15263
uniprot
O15263
canonical
amino_acid_sequence
MRVLYLLFSFLFIFLMPLPGVFGGIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP
uniprot
proteins
function
FUNCTION: Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria, with highest activity against Gram-negative bacteria (PubMed:10837369, PubMed:9202117). Antimicrobial activity against P.aeruginosa seems to be salt-sensitive and is reduced with high salt concentrations greater than 25 mM (PubMed:10837369). Also exhibits antimicrobial activity against the yeast C.albicans (PubMed:10837369, PubMed:30050988, PubMed:9202117). Permeabilizes C.albicans cell membranes via targeting plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), thereby leading to cell fragmentation and cell death (PubMed:30050988). Acts as a ligand for C-C chemokine receptor CCR6 (PubMed:10521347, PubMed:20068036). Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells, such as immature dendritic cells and memory T cells (PubMed:10521347, PubMed:20068036). {ECO:0000269|PubMed:10521347, ECO:0000269|PubMed:10837369, ECO:0000269|PubMed:20068036, ECO:0000269|PubMed:30050988, ECO:0000269|PubMed:9202117}.
uniprot
proteins
mass_dalton
7038
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="K->A: Loss of PIP2 binding and loss of liposomal lysis activity. Decrease in fungal cell permeabilization. Impaired antifungal activity."; /evidence="ECO:0000269|PubMed:30050988"; MUTAGEN 45; /note="R->A: Loss of PIP2 binding and loss of liposomal lysis activity. Decrease in fungal cell permeabilization. Impaired antifungal activity."; /evidence="ECO:0000269|PubMed:30050988"; MUTAGEN 46; /note="R->A: No impact on fungal cell permeabilization. Impaired antifungal activity."; /evidence="ECO:0000269|PubMed:30050988"; MUTAGEN 47; /note="Y->A: No impact on fungal cell permeabilization. No impact on antifungal activity."; /evidence="ECO:0000269|PubMed:30050988"; MUTAGEN 48; /note="K->A: Loss of PIP2 binding and reduced liposomal lysis activity. Impaired antifungal activity. Decrease in fungal cell permeabilization."; /evidence="ECO:0000269|PubMed:30050988"; MUTAGEN 59; /note="K->A: No impact on PIP binding and liposomal lysis activity. Lack of antifungal activity. Lack of fungal cell permeabilization."; /evidence="ECO:0000269|PubMed:30050988
uniprot
proteins
protein_family
Beta-defensin family
uniprot
proteins
protein_family
LAP/TAP subfamily
uniprot
proteins
pubmed
10521347
uniprot
proteins
pubmed
10603376
uniprot
proteins
pubmed
10837369
uniprot
proteins
pubmed
10906336
uniprot
proteins
pubmed
11300761
uniprot
proteins
pubmed
11714914
uniprot
proteins
pubmed
12010514
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20068036
uniprot
proteins
pubmed
30050988
uniprot
proteins
pubmed
9202117
uniprot
proteins
pubmed
9831658
uniprot
proteins
sequence_length
64
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10837369}.
uniprot
proteins