Laptm4b
entrez
114128
canonical
uniprot
Q91XQ6
canonical
ensembl
ENSMUSG00000022257
resolver
ensp
ENSMUSP00000022867
resolver
enst
ENSMUST00000022867
resolver
genesymbol
Laptm4b
resolver
uniprot
B2CZK6
resolver
uniprot_entry
B2CZK6_MOUSE
resolver
uniprot_entry
LAP4B_MOUSE
resolver
amino_acid_sequence
MKMVAPWTRFYSHSCCLCCHVRTGTILLGVWYLIINAVVLLILLSALADPNQYHFSGSELGGEFEFMDDANMCIAIAISLLMILICAMATYGAYKQHAAWIIPFFCYQIFDFALNTLVAITVLVYPNSIQEYIRQLPPSFPYRDDIMSVNPTCLVLIILLFIGILLTLKGYLISCVWSCYRYINGRNSSDVLVYVTSNDTTVLLPPYDDATAVPSTAKEPPPPYVSA
uniprot
proteins
function
FUNCTION: Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways. {ECO:0000250|UniProtKB:Q86VI4}.
uniprot
proteins
mass_dalton
25395
uniprot
proteins
post_translational_modification
PTM: Undergoes proteolytic cleavage following delivery to the lysosomes. {ECO:0000250|UniProtKB:Q86VI4}.; PTM: Ubiquitinated by NEDD4. {ECO:0000250|UniProtKB:Q86VI4}.
uniprot
proteins
protein_family
LAPTM4/LAPTM5 transporter family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
227
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250|UniProtKB:Q86VI4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q86VI4}. Late endosome membrane {ECO:0000250|UniProtKB:Q86VI4}. Cell membrane {ECO:0000250|UniProtKB:Q86VI4}. Cell projection {ECO:0000250|UniProtKB:Q86VI4}. Lysosome membrane {ECO:0000250|UniProtKB:Q86VI4}. Endosome membrane {ECO:0000250|UniProtKB:Q86VI4}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:Q86VI4}. Endosome, multivesicular body lumen {ECO:0000250|UniProtKB:Q86VI4}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 153..173; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins