Cd2ap
entrez
12488
canonical
uniprot
Q9JLQ0
canonical
ensembl
ENSMUSG00000061665
resolver
ensp
ENSMUSP00000024709
resolver
ensp
ENSMUSP00000156812
resolver
ensp
ENSMUSP00000244730
resolver
enst
ENSMUST00000024709
resolver
enst
ENSMUST00000233476
resolver
genesymbol
Cd2ap
resolver
genesymbol_syn
Mets1
resolver
uniprot
A0A3B2W812
resolver
uniprot
E9QL86
resolver
uniprot
O88903
resolver
uniprot
Q8K4Z1
resolver
uniprot
Q8VCI9
resolver
uniprot_entry
A0A3B2W812_MOUSE
resolver
uniprot_entry
CD2AP_MOUSE
resolver
uniprot_sec
E9QL86
resolver
uniprot_sec
O88903
resolver
uniprot_sec
Q8K4Z1
resolver
uniprot_sec
Q8VCI9
resolver
amino_acid_sequence
MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEPKDDNLPIKRERQGNVASLVQRISTYGLPAGGIQPHPQTKAIKKKTKKRQCKVLFDYSPQNEDELELIVGDVIDVIEEVEEGWWSGTLNNKLGLFPSNFVKELESTEDGETHNAQEESEVPLTGPTSPLPSPGNGSEPAPGSVAQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKTEKPLILQPLGSRTQNVEVTKPDVDGKIKAKEYCRTLFPYTGTNEDELTFREGEIIHLISKETGEAGWWKGELNGKEGVFPDNFAVQISELDKDFPKPKKPPPPAKGPAPKPDLSAAEKKAFPLKAEEKDEKSLLEQKPSKPAAPQVPPKKPTAPTKASNLLRSPGAVYPKRPEKPVPPPPPAAKINGEVSIISSKIDTEPVSKPKLDPEQLPVRPKSVDLDAFVARNSKETDDVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTQSPEKTLKLPKEDDSGNLKPLEFKKDASYSSKSSLSTPSSASKVNTAAFLTPLELKAKAEADDGKRNSVDELRAQIIELLCIVDALKKDHGKELEKLRKELEEEKAMRSNLEVEIAKLKKAVLLS
uniprot
proteins
function
FUNCTION: Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (By similarity). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (PubMed:9741631). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus (PubMed:10514378). Also required for cytokinesis. Plays a role in epithelial cell junctions formation (By similarity). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9Y5K6, ECO:0000269|PubMed:10514378, ECO:0000269|PubMed:9741631}.
uniprot
proteins
mass_dalton
70450
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues; probably by c-Abl, Fyn and c-Src. {ECO:0000250}.
uniprot
proteins
pubmed
10514378
uniprot
proteins
pubmed
10913159
uniprot
proteins
pubmed
11733379
uniprot
proteins
pubmed
11733557
uniprot
proteins
pubmed
12217865
uniprot
proteins
pubmed
14736876
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17537921
uniprot
proteins
pubmed
17922258
uniprot
proteins
pubmed
18753381
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9741631
uniprot
proteins
sequence_length
637
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9Y5K6}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9Y5K6}. Cell junction {ECO:0000250|UniProtKB:Q9Y5K6}. Note=Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles (By similarity). Located at podocyte slit diaphragm between podocyte foot processes (PubMed:10514378, PubMed:11733379). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase (By similarity). {ECO:0000250|UniProtKB:Q9Y5K6, ECO:0000269|PubMed:10514378, ECO:0000269|PubMed:11733379}.
uniprot
proteins