DND1
entrez
373863
canonical
uniprot
Q8IYX4
canonical
ensembl
ENSG00000256453
resolver
ensp
ENSP00000445366
resolver
enst
ENST00000542735
resolver
genesymbol
DND1
resolver
genesymbol_syn
RBMS4
resolver
hgnc
HGNC:23799
resolver
uniprot_entry
DND1_HUMAN
resolver
amino_acid_sequence
MQSKRDCELWCERVNPENKAALEAWVRETGIRLVQVNGQRKYGGPPPGWVGSPPPAGSEVFIGRLPQDVYEHQLIPLFQRVGRLYEFRLMMTFSGLNRGFAYARYSSRRGAQAAIATLHNHPLRPSCPLLVCRSTEKCELSVDGLPPNLTRSALLLALQPLGPGLQEARLLPSPGPAPGQIALLKFSSHRAAAMAKKALVEGQSHLCGEQVAVEWLKPDLKQRLRQQLVGPFLRSPQPEGSQLALARDKLGFQGARATLQLLCQRMKLGSPVFLTKCLGIGPAGWHRFWYQVVIPGHPVPFSGLIWVVLTLDGRDGHEVAKDAVSVRLLQALSESGANLLWSAGAEAGTMVKQ
uniprot
proteins
function
FUNCTION: RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity). {ECO:0000250, ECO:0000269|PubMed:18155131}.
uniprot
proteins
mass_dalton
38687
uniprot
proteins
pubmed
12932328
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18155131
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18155131}. Cytoplasm {ECO:0000269|PubMed:18155131}. Note=Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity). {ECO:0000250}.
uniprot
proteins