Rab28
entrez
117049
canonical
uniprot
P51158
canonical
ensembl
ENSRNOG00000017074
resolver
ensembl
ENSRNOG00055015372
resolver
ensembl
ENSRNOG00060024433
resolver
ensembl
ENSRNOG00065005501
resolver
ensp
ENSRNOP00000050260
resolver
ensp
ENSRNOP00000080796
resolver
ensp
ENSRNOP00055021345
resolver
ensp
ENSRNOP00060035097
resolver
ensp
ENSRNOP00065005690
resolver
enst
ENSRNOT00000041310
resolver
enst
ENSRNOT00000117951
resolver
enst
ENSRNOT00055026244
resolver
enst
ENSRNOT00060042339
resolver
enst
ENSRNOT00065008135
resolver
genesymbol
Rab28
resolver
uniprot
A0A8I5ZQN9
resolver
uniprot
F7EVT4
resolver
uniprot
Q6IN03
resolver
uniprot_entry
A0A8I5ZQN9_RAT
resolver
uniprot_entry
F7EVT4_RAT
resolver
uniprot_entry
Q6IN03_RAT
resolver
uniprot_entry
RAB28_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:P51157}.
uniprot
proteins
amino_acid_sequence
MSDSEEESQDRQLKIVVLGDGTSGKTSLATCFAQETFGKQYKQTIGLDFFLRRITLPGNLNVTLQVWDIGGQTIGGKMLDKYIYGAQGILLVYDITNYQSFENLEDWYSVVKTVSEESETQPLVALVGNKIDLEHMRTVKPDKHLRFCQENGFSSHFVSAKTGDSVFLCFQKVAAEILGIKLNKAEIEQSQRVVKADIVNYNQEPMSRTVNPPRSSMCAVQ
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB28 is required for shedding and phagocytosis of cone cell outer segments (OS) discs in the retina (By similarity). Also participates in nuclear factor kappa-B p65/RELA nuclear transport in endothelial cells (PubMed:23457503). {ECO:0000250|UniProtKB:P51157, ECO:0000250|UniProtKB:Q99KL7, ECO:0000269|PubMed:23457503}.
uniprot
proteins
mass_dalton
24772
uniprot
proteins
post_translational_modification
PTM: Isoprenylated. {ECO:0000250|UniProtKB:P51157}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
23457503
uniprot
proteins
pubmed
23746546
uniprot
proteins
pubmed
8647132
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23746546}. Cytoplasm {ECO:0000269|PubMed:23457503}. Nucleus {ECO:0000269|PubMed:23457503}. Note=Expressed in the basal body and ciliary rootlet of the photoreceptors (PubMed:23746546). Localized in the cytoplasm and the nucleus of vascular endothelial cells (PubMed:23457503). {ECO:0000269|PubMed:23457503, ECO:0000269|PubMed:23746546}.
uniprot
proteins