Slitrk2
entrez
245450
canonical
uniprot
Q810C0
canonical
ensembl
ENSMUSG00000036790
resolver
ensp
ENSMUSP00000044094
resolver
ensp
ENSMUSP00000130057
resolver
ensp
ENSMUSP00000234269
resolver
ensp
ENSMUSP00000234270
resolver
ensp
ENSMUSP00000234271
resolver
enst
ENSMUST00000036043
resolver
enst
ENSMUST00000166241
resolver
genesymbol
Slitrk2
resolver
uniprot
Q14DT0
resolver
uniprot
Q8BXL6
resolver
uniprot_entry
Q14DT0_MOUSE
resolver
uniprot_entry
SLIK2_MOUSE
resolver
uniprot_sec
Q8BXL6
resolver
amino_acid_sequence
MLSGVWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRPGAFSGLKTLKRLHLNNNKLEVLREDTFLGLESLEYLQADYNYISTIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDLCPRKSASGDSSQRSSHSDTHVQRLTPTTNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVALTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICPENPNLSDGTILSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPNVPRNATNLDVSSFQLQYGSYNTETNDKADGHVYNYIPPPVGQMCQNPIYMQKEGDPVAYYRNLQDFSYGNLEEKKEEPATLAYTISATELLEKQATPREPELLYQNIAERVKELPSAGLVHYNFCTLPKRQFAPSYESRRQNQDRINKTVLYGTPRKCFVGQSKPDHPLLQAKPQSEPDYLEVLEKQTAISQL
uniprot
proteins
function
FUNCTION: It is involved in synaptogenesis (PubMed:25989451, PubMed:35840571). Promotes excitatory synapse differentiation (By similarity). Suppresses neurite outgrowth (PubMed:14550773). Involved in the negative regulation of NTRK2 (PubMed:35840571). {ECO:0000250|UniProtKB:Q9H156, ECO:0000269|PubMed:14550773, ECO:0000269|PubMed:25989451, ECO:0000269|PubMed:35840571}.
uniprot
proteins
mass_dalton
95436
uniprot
proteins
mutagenesis
MUTAGEN 114; /note="R->A: No effect on interaction with PTPRD. No effect on synapse assembly."; /evidence="ECO:0000269|PubMed:25989451"; MUTAGEN 167; /note="D->A: Abolishes interaction with PTPRD. Abolishes synapse assembly."; /evidence="ECO:0000269|PubMed:25989451"; MUTAGEN 187; /note="D->A: Abolishes interaction with PTPRD. Abolishes synapse assembly."; /evidence="ECO:0000269|PubMed:25989451"; MUTAGEN 215; /note="E->A: Abolishes interaction with PTPRD. Significantly reduces synapse assembly."; /evidence="ECO:0000269|PubMed:25989451"; MUTAGEN 247..250; /note="FRLH->ARLA: No effect on interaction with PTPRD. No effect on synapse assembly."; /evidence="ECO:0000269|PubMed:25989451
uniprot
proteins
protein_family
SLITRK family
uniprot
proteins
pubmed
14550773
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
25989451
uniprot
proteins
pubmed
35840571
uniprot
proteins
sequence_length
846
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q9H156}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9H156}.
uniprot
proteins
transmembrane_region
TRANSMEM 623..643; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins