Dok1
entrez
13448
canonical
uniprot
P97465
canonical
ensembl
ENSMUSG00000068335
resolver
ensp
ENSMUSP00000087079
resolver
enst
ENSMUST00000089651
resolver
genesymbol
Dok1
resolver
genesymbol_syn
Dok
resolver
uniprot
Q3UWF9
resolver
uniprot
Q9R213
resolver
uniprot_entry
DOK1_MOUSE
resolver
uniprot_entry
Q3UWF9_MOUSE
resolver
uniprot_sec
Q9R213
resolver
amino_acid_sequence
MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSRGGRGGSRRLDCKMIRLAECVSVVPVTVESPPEPGAVAFRLDTAQRSHLLAADAVSSTAWVQTLCRTAFPKGGWALAQTENQPKFSALEMLENSLYSPTWEGSQFWVTSQKTEASERCGLQGSYILRVEAEKLTLLTLGAQSQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTSQGNDIFQAVEAAIQQQKAQGKVGQAQDILRTDSHDGETEGKTVPPPVPQDPLGSPPALYAEPLDSLRIPPGPSQDSVYSDPLGSTPAGAGEGVHSKKPLYWDLYGHVQQQLLKTKLTDSKEDPIYDEPEGLAPAPPRGLYDLPQEPRDAWWCQARLKEEGYELPYNPATDDYAVPPPRSPKPAPAPKPQGLILPESGTTRGSGSKGFSSDTALYSQVQKSGTSGAWDCGLSKVGNDRAGVKSEGST
uniprot
proteins
function
FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
52452
uniprot
proteins
post_translational_modification
PTM: Constitutively tyrosine-phosphorylated. Phosphorylated by TEC. Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway (By similarity). Phosphorylated by LYN. Phosphorylated on tyrosine residues by SRMS (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
DOK family
uniprot
proteins
protein_family
Type A subfamily
uniprot
proteins
pubmed
10640270
uniprot
proteins
pubmed
10822173
uniprot
proteins
pubmed
11031258
uniprot
proteins
pubmed
14607833
uniprot
proteins
pubmed
14747716
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9008161
uniprot
proteins
pubmed
9872994
uniprot
proteins
pubmed
9927484
uniprot
proteins
sequence_length
482
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins