Slco1a1
entrez
28248
canonical
uniprot
Q9QXZ6
canonical
ensembl
ENSMUSG00000041698
resolver
ensp
ENSMUSP00000037022
resolver
enst
ENSMUST00000042119
resolver
genesymbol
Slco1a1
resolver
genesymbol_syn
Oatp1a1
resolver
genesymbol_syn
Slc21a1
resolver
uniprot
Q53ZW9
resolver
uniprot_entry
Q53ZW9_MOUSE
resolver
uniprot_entry
SO1A1_MOUSE
resolver
amino_acid_sequence
MEETEKKVATQEGRFFSKMKVFLMSLTCAYLAKSLSGVYMNSMLTQIERQFGIPTSVVGFITGSFEIGNLLLIVFVSYFGRKLHRPIIIGVGCVVMGLGCFLMASPHFLMGRYKYETTISPTSNLSSNSFLCIENRTQTLKPTQDPTECVKEIKSLMWIYVLIGNTMRGIGETPIMPLGISYIEDFAKSENSPLYIGILEMGKIVGPIIGLLLGSFFARVYVDIGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLPKKELQDNVDVTKYEKVEKHRERAKKENLGITKDFLPFMKSLCCNPIYMLFSLTSVLQINGFASTFTFLPKYLEQQYGKSTSEAVFLIGVYSLPPVCLGYLISGFIMKKFKITVKKAAYIAFGLSLSEYFIFLCNYLLTCDNFPVAGLTTSYKGVQHPLYGEKNVLADCNTRCSCLTDTWDPVCGDNGLAYMSACLAGCEKSVGTGTNMVFQNCSCIGSSGNSSAVLGLCKKGPECDNKLQYFLIKSVFSSFIFSLAAIPGYMVLLRCVKSEEKSIGVGLHAFFIRLLAGIPAPVYFGALIDRTCLHWGTLKCGQPGACRMYDINRFRHIYLGLPAAVRGSSFLPAVFILILMRKFHFPGDIHSPDTELAEMKLTEKESECTDVCRSPKVENDGELKTKL
uniprot
proteins
function
FUNCTION: Mediates the Na(+)-independent transport of organic anions such as steroid sulfate conjugates (dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate), conjugated (taurocholate) and unconjugated (cholate) bile acids, prostaglandin E2 (PGE2) and L-thyroxine T4 (PubMed:10600646, PubMed:11267661). Also capable of transporting sulfobromophthalein (BSP), ouabain and gadoxetate (PubMed:10600646). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (By similarity). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (By similarity). {ECO:0000250|UniProtKB:P46720, ECO:0000269|PubMed:10600646, ECO:0000269|PubMed:11267661}.
uniprot
proteins
mass_dalton
74396
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
10600646
uniprot
proteins
pubmed
11267661
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
670
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:P46720}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P46720}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..40; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 60..80; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 87..111; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 156..184; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 243..267; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 312..333; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 354..377; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 382..405; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 514..536; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 546..571; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 606..623; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins