CD58
entrez
965
canonical
uniprot
P19256
canonical
ensembl
ENSG00000116815
resolver
ensp
ENSP00000358501
resolver
ensp
ENSP00000409080
resolver
genesymbol
CD58
resolver
genesymbol_syn
LFA3
resolver
hgnc
HGNC:1688
resolver
uniprot
A8K7G5
resolver
uniprot
Q5U053
resolver
uniprot
Q6IB65
resolver
uniprot
Q96KI9
resolver
uniprot_entry
LFA3_HUMAN
resolver
uniprot_sec
A8K7G5
resolver
uniprot_sec
Q5U053
resolver
uniprot_sec
Q6IB65
resolver
uniprot_sec
Q96KI9
resolver
amino_acid_sequence
MVAGSDAGRALGVLSVVCLLHCFGFISCFSQQIYGVVYGNVTFHVPSNVPLKEVLWKKQKDKVAELENSEFRAFSSFKNRVYLDTVSGSLTIYNLTSSDEDEYEMESPNITDTMKFFLYVLESLPSPTLTCALTNGSIEVQCMIPEHYNSHRGLIMYSWDCPMEQCKRNSTSIYFKMENDLPQKIQCTLSNPLFNTTSSIILTTCIPSSGHSRHRYALIPIPLAVITTCIVLYMNGILKCDRKPDRTNSN
uniprot
proteins
function
FUNCTION: Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
uniprot
proteins
mass_dalton
28147
uniprot
proteins
mutagenesis
MUTAGEN 29; /note="F->S: No effect on CD2-binding."; /evidence="ECO:0000269|PubMed:10380930"; MUTAGEN 37; /note="V->K: No effect on CD2-binding."; /evidence="ECO:0000269|PubMed:10380930"; MUTAGEN 49; /note="V->Q: No effect on CD2-binding."; /evidence="ECO:0000269|PubMed:10380930"; MUTAGEN 86; /note="V->K: No effect on CD2-binding."; /evidence="ECO:0000269|PubMed:10380930"; MUTAGEN 113; /note="T->S: No effect on CD2-binding."; /evidence="ECO:0000269|PubMed:10380930"; MUTAGEN 121; /note="L->G: No effect on CD2-binding."; /evidence="ECO:0000269|PubMed:10380930
uniprot
proteins
pubmed
10200255
uniprot
proteins
pubmed
10380930
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17566972
uniprot
proteins
pubmed
28813417
uniprot
proteins
pubmed
29691324
uniprot
proteins
pubmed
3309127
uniprot
proteins
pubmed
3313052
uniprot
proteins
pubmed
9510189
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 216..238; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins