Pld2
entrez
18806
canonical
uniprot
P97813
canonical
ensembl
ENSMUSG00000020828
resolver
ensp
ENSMUSP00000018429
resolver
ensp
ENSMUSP00000104196
resolver
ensp
ENSMUSP00000104197
resolver
ensp
ENSMUSP00000245792
resolver
ensp
ENSMUSP00000245793
resolver
ensp
ENSMUSP00000245794
resolver
ensp
ENSMUSP00000245795
resolver
enst
ENSMUST00000018429
resolver
enst
ENSMUST00000108556
resolver
enst
ENSMUST00000108557
resolver
genesymbol
Pld2
resolver
uniprot
F6R3E7
resolver
uniprot
F6R3F6
resolver
uniprot
Q3UNY4
resolver
uniprot
Q5SXG5
resolver
uniprot
Q6NV49
resolver
uniprot
Q80ZW1
resolver
uniprot_entry
F6R3E7_MOUSE
resolver
uniprot_entry
F6R3F6_MOUSE
resolver
uniprot_entry
PLD2_MOUSE
resolver
uniprot_entry
Q3UNY4_MOUSE
resolver
uniprot_entry
Q5SXG5_MOUSE
resolver
uniprot_entry
Q6NV49_MOUSE
resolver
uniprot_entry
Q80ZW1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by phosphatidylinositol 4,5-bisphosphate. Is not responsive to either ADP-ribosylation factor-1 (ARF-1) or GTP-binding proteins such as RHOA. {ECO:0000269|PubMed:9395408}.
uniprot
proteins
amino_acid_sequence
MTVTQKNLFPYGDYLNSSQLHMEPDEVDTLREGEDPADRMHPYLAIYDLQPLKAHPLVFAPGVPVIAQVVGTERYTSGSKVGTCTLYSVRLTHGDFTWTTKKKFRHFQELHRDLQRHKVLMSLLPLARFAVTHSPAREAAAEDIPSLPRGGSEGSARHTASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGSKGLEGVIRKRSGGHRVPGFTFCGRDQVCYRWSKRWLVVKDSFLLYMRPETGAISFVQLFDPGFEVQVGKRSTETRYGVRIDTSHRSLILKCSSYRQARWWGQEITELAQGSGRDFLQLHQHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEIYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRTLMLLHPNIKVMRHPDLVTLWAHHEKLLVVDQVVAFLGGLDLAFGRWDDVQYRLTDLGDPSEPVHLQTPTLGSDPAATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGVAARDLARHFIQRWNFTKTTKARYKTPLYPYLLPKSTSTANNLPFMIPGGQCATVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHEQGQCFRVYLLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEHSILHRLKAAMGTAWRDYMSICGLRTHGELGGHPISELIYIHSKMLIADDRTVIIGSANINDRSLLGKRDSELAILIKDTEMEPSLMDGVEYQAGRFALSLRKHCFSVILGANTWPDLDLRDPVCDDFFQLWQETAENNATIYEQIFRCLPSNATRSLRALREYVAVESLATVSPSLAQSELAHIQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT
uniprot
proteins
ec_number
3.1.4.4
uniprot
proteins
function
FUNCTION: Function as phospholipase selective for phosphatidylcholine (PubMed:21085684). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (PubMed:9395408). {ECO:0000269|PubMed:21085684, ECO:0000269|PubMed:9395408}.
uniprot
proteins
mass_dalton
106168
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="Y->F: 2-fold increase in basal phospholipase activity."; /evidence="ECO:0000269|PubMed:9837959
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FGR (By similarity). Phosphorylated on Tyr-11; most likely by EGFR (PubMed:9837959). {ECO:0000250|UniProtKB:P70498, ECO:0000269|PubMed:9837959}.
uniprot
proteins
protein_family
Phospholipase D family
uniprot
proteins
pubmed
21085684
uniprot
proteins
pubmed
9307024
uniprot
proteins
pubmed
9395408
uniprot
proteins
pubmed
9560313
uniprot
proteins
pubmed
9837959
uniprot
proteins
sequence_length
933
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9395408}; Lipid-anchor {ECO:0000305}.
uniprot
proteins