Spink2
entrez
69982
canonical
uniprot
Q8BMY7
canonical
ensembl
ENSMUSG00000053030
resolver
ensp
ENSMUSP00000067117
resolver
ensp
ENSMUSP00000112806
resolver
ensp
ENSMUSP00000113823
resolver
enst
ENSMUST00000120429
resolver
genesymbol
Spink2
resolver
uniprot
D3YTY0
resolver
uniprot
D3Z3X9
resolver
uniprot
Q5M8S4
resolver
uniprot_entry
D3YTY0_MOUSE
resolver
uniprot_entry
ISK2_MOUSE
resolver
uniprot_sec
D3Z3X9
resolver
uniprot_sec
Q5M8S4
resolver
amino_acid_sequence
MLRLVLLLLVTDFAASHETLDSSDSQIMKRSQFRTPDCGHFDFPACPRNLNPVCGTDMNTYSNECTLCMKIREDGSHINIIKDEPC
uniprot
proteins
function
FUNCTION: As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:21705336, PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (PubMed:21705336). It also inhibits trypsin (PubMed:21705336). {ECO:0000269|PubMed:21705336, ECO:0000269|PubMed:28554943}.
uniprot
proteins
mass_dalton
9722
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21705336
uniprot
proteins
pubmed
28554943
uniprot
proteins
sequence_length
86
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P20155}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:28554943}.
uniprot
proteins