Acox3
entrez
83522
canonical
uniprot
Q63448
canonical
ensembl
ENSRNOG00000008474
resolver
ensp
ENSRNOP00000092103
resolver
genesymbol
Acox3
resolver
genesymbol_syn
Prcox
resolver
uniprot_entry
ACOX3_RAT
resolver
amino_acid_sequence
MGSSSERRDSVLWSDIPKGPLSAYRARASFNSKELMLFWDGQDVLDFKKTIFSTLENDPLFARPFGADLPLEKERELNFLRCKRVFEYGFFNAEDMLKNPLKILVLMNCLGMYDWSLANKCVLHMLVFGSTIIGSGSEHHFKYLEKIYNLEIFGCFALTELSHGSNTKAMRTTAHYDPATQEFILHSPDFEAAKFWVGNLGKTATHAVVFAQLYTPDGQCRGLHSFLVQIRDPKTLLPMPGVMVGDMGKKLGQNGLDNGFAMFHKVRIPRQNLLDRTGNVTSEGHYHTPFKDVRQRLGASLGSLSSGRISIISISVVNLKLAVIIAIRFSATRRQFGPTDKEEIPVLEYPLQQWRLLPYLAAAYALDHFSKTIFLDLIELQRAGKVGTTVTGRQSSGREIHALASAGKPLASWTAQRGIQECREVVGGHGYLAMNRFGELRNDNDPNCTYEGDNNVLLQQTSNYLLSLLEHPLQDGAHFTSPLKTVNFLEAYPGILGQKFMASSKADWLDSEAPLAAYRWLVCYLLRESHQRYCQEKKSRGSDFEARNNSQVYGCRPLALAFMELTVMQRFHEHTHSSSVPPSLRTVLGRLSMLYGLWCLSQHTALLYRGGYISGEQTGKAMEDAILMLCVQLKDDAVALVDAIAPSDFVLGSPIGRADGELYKNLWAAVLQQSGVLERAAWWPEFTANKSVANRLKSQL
uniprot
proteins
ec_number
1.3.3.6
uniprot
proteins
function
FUNCTION: Involved in peroxisomal beta-oxidation of branched-chain fatty acids (BCFAs). Catalyzes the initial and rate-limiting dehydrogenation step that removes two hydrogen molecules and introduces a trans double bond between the alpha and beta carbons of the acyl CoA molecules while generating hydrogen peroxide as a by-product (Probable). Metabolizes multi-methyl-branched fatty acyl-CoA esters such as (2S)-pristanoyl-CoA, displaying redundancy with ACOX3 (Probable). Can oxidize straight-chain mono- and dicarboxylyl fatty acyl-CoAs with lower efficiency (Probable). {ECO:0000305|PubMed:1400324, ECO:0000305|PubMed:8706733}.
uniprot
proteins
mass_dalton
78446
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation. {ECO:0000305|PubMed:1400324}.
uniprot
proteins
protein_family
Acyl-CoA oxidase family
uniprot
proteins
pubmed
1400324
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8706733
uniprot
proteins
sequence_length
700
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000305|PubMed:8706733}.
uniprot
proteins