TAF7
entrez
6879
canonical
uniprot
Q15545
canonical
ensembl
ENSG00000178913
resolver
ensp
ENSP00000312709
resolver
ensp
ENSP00000485510
resolver
enst
ENST00000313368
resolver
enst
ENST00000624761
resolver
genesymbol
TAF7
resolver
genesymbol_syn
TAF2F
resolver
genesymbol_syn
TAFII55
resolver
hgnc
HGNC:11541
resolver
uniprot
B2RBV9
resolver
uniprot
Q13036
resolver
uniprot_entry
TAF7_HUMAN
resolver
uniprot_sec
B2RBV9
resolver
uniprot_sec
Q13036
resolver
amino_acid_sequence
MSKSKDDAPHELESQFILRLPPEYASTVRRAVQSGHVNLKDRLTIELHPDGRHGIVRVDRVPLASKLVDLPCVMESLKTIDKKTFYKTADICQMLVSTVDGDLYPPVEEPVASTDPKASKKKDKDKEKKFIWNHGITLPLKNVRKRRFRKTAKKKYIESPDVEKEVKRLLSTDAEAVSTRWEIIAEDETKEAENQGLDISSPGMSGHRQGHDSLEHDELREIFNDLSSSSEDEDETQHQDEEDINIIDTEEDLERQLQDKLNESDEQHQENEGTNQLVMGIQKQIDNMKGKLQETQDRAKRQEDLIMKVENLALKNRFQAVLDELKQKEDREKEQLSSLQEELESLLEK
uniprot
proteins
function
FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10438527, PubMed:33795473). TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 (PubMed:33795473). Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) (PubMed:10438527). {ECO:0000269|PubMed:10438527, ECO:0000269|PubMed:33795473}.
uniprot
proteins
mass_dalton
40259
uniprot
proteins
mutagenesis
MUTAGEN 5; /note="K->R: Abolishes methylation in vitro."; /evidence="ECO:0000269|PubMed:16415881"; MUTAGEN 264; /note="S->A: Reduced H3 acetylation and transcription at target promoters."; /evidence="ECO:0000269|PubMed:22711989"; MUTAGEN 264; /note="S->D: 50% reduction in TAF1-binding, reduced incorporation of TAF7 into TFIID complexes."; /evidence="ECO:0000269|PubMed:22711989
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CIITA. Phosphorylation at Ser-264 by TAF1 in early G1 phase disrupts binding to TAF1. {ECO:0000269|PubMed:22711989, ECO:0000269|PubMed:24036077}.; PTM: Ubiquitinated by TRIM26; leading to proteasomal degradation. {ECO:0000269|PubMed:29203640}.
uniprot
proteins
protein_family
TAF7 family
uniprot
proteins
pubmed
10438527
uniprot
proteins
pubmed
11340078
uniprot
proteins
pubmed
11592977
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15960975
uniprot
proteins
pubmed
16415881
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20937824
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22711989
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24036077
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25412659
uniprot
proteins
pubmed
27007846
uniprot
proteins
pubmed
29203640
uniprot
proteins
pubmed
33795473
uniprot
proteins
pubmed
7824954
uniprot
proteins
pubmed
8702684
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9R1C0}.
uniprot
proteins