Pard6b
entrez
58220
canonical
uniprot
Q9JK83
canonical
ensembl
ENSMUSG00000044641
resolver
ensp
ENSMUSP00000052619
resolver
genesymbol
Pard6b
resolver
genesymbol_syn
Par6b
resolver
uniprot
A2ANX8
resolver
uniprot
Q8R3J8
resolver
uniprot_entry
PAR6B_MOUSE
resolver
uniprot_sec
A2ANX8
resolver
uniprot_sec
Q8R3J8
resolver
amino_acid_sequence
MNRGHRHGASSGCLGTMEVKSKFGAEFRRFSLERSKPGKFEEFYGLLQHVHKIPNVDVLVGYADIHGDLLPINNDDNYHKAVSTANPLLRIFIQKKEEADYSAFGTDTLIRKKNMLSNVLRPDNHRKKPHIVISMPQDFRPVSSIIDVDILPETHRRVRLYKYGTEKPLGFYIRDGSSVRVTPHGLEKVPGIFISRLVPGGLAQSTGLLAVNDEVLEVNGIEVSGKSLDQVTDMMIANSRNLIITVRPANQRNNVVRNSRTSGSSSQSTDNSLLGFPQQVEASFEPEDQDSDEDDIIIEDSGEPQQIPKATPAQSLESLTQIELSFESGQNGFSPPQDTSLVPVPGSLDTELESRAPDQKLLEEDGTIITL
uniprot
proteins
function
FUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. {ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:11839275}.
uniprot
proteins
mass_dalton
41067
uniprot
proteins
mutagenesis
MUTAGEN 133..134; /note="IS->AA: Does not abolish interaction with CDC42 and RHOQ."; /evidence="ECO:0000269|PubMed:10934474"; MUTAGEN 136; /note="P->A: Abolishes interaction with RHOQ, but not the interaction with CDC42; when associated with A-139."; /evidence="ECO:0000269|PubMed:10934474"; MUTAGEN 139; /note="F->A: Abolishes interaction with RHOQ, but not the interaction with CDC42; when associated with A-136."; /evidence="ECO:0000269|PubMed:10934474"; MUTAGEN 167..170; /note="KPLG->AAAA: Strongly reduces interaction with PARD3. Does not abolish interaction with CDC42 and RHOQ."; /evidence="ECO:0000269|PubMed:10934474"; MUTAGEN 235; /note="M->W: Prevents interaction with PALS1."; /evidence="ECO:0000269|PubMed:15140881
uniprot
proteins
protein_family
PAR6 family
uniprot
proteins
pubmed
10934474
uniprot
proteins
pubmed
11839275
uniprot
proteins
pubmed
12545177
uniprot
proteins
pubmed
12606577
uniprot
proteins
pubmed
15140881
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
371
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Cell junction, tight junction. Note=Colocalizes with active form of CDC42 or RAC1 at membrane ruffles. Also localizes to tight junctions.
uniprot
proteins