Dbnl
entrez
13169
canonical
uniprot
Q62418
canonical
ensembl
ENSMUSG00000020476
resolver
ensp
ENSMUSP00000020769
resolver
ensp
ENSMUSP00000099992
resolver
ensp
ENSMUSP00000105471
resolver
genesymbol
Dbnl
resolver
genesymbol_syn
Abp1
resolver
genesymbol_syn
Sh3p7
resolver
uniprot
Q3TG34
resolver
uniprot
Q3U5X3
resolver
uniprot
Q3U8I5
resolver
uniprot
Q3UZ33
resolver
uniprot
Q5NCI5
resolver
uniprot
Q5NCI6
resolver
uniprot
Q5NCI7
resolver
uniprot
Q80WP1
resolver
uniprot
Q8BH56
resolver
uniprot_entry
DBNL_MOUSE
resolver
uniprot_sec
Q3TG34
resolver
uniprot_sec
Q3U5X3
resolver
uniprot_sec
Q3U8I5
resolver
uniprot_sec
Q3UZ33
resolver
uniprot_sec
Q5NCI5
resolver
uniprot_sec
Q5NCI6
resolver
uniprot_sec
Q5NCI7
resolver
uniprot_sec
Q80WP1
resolver
uniprot_sec
Q8BH56
resolver
amino_acid_sequence
MAVNLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEELVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACANHVSTMANFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESTSFQDVGPQAPVGSVYQKTNAISEIKRVGKDNFWAKAEKEEENRRLEEKRRAEEERQRLEEERRERELQEAARREQRYQEQHRSAGAPSPSSRTGEPEQEAVSRTRQEWESAGQQAPHPREIFKQKERAMSTTSVTSSQPGKLRSPFLQKQLTQPETSYGREPTAPVSRPAAGVCEEPAPSTLSSAQTEEEPTYEVPPEQDTLYEEPPLVQQQGAGSEHIDNYMQSQGFSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
uniprot
proteins
function
FUNCTION: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000269|PubMed:11309416, ECO:0000269|PubMed:17476322, ECO:0000269|PubMed:18829961, ECO:0000269|PubMed:22303001, ECO:0000269|PubMed:23223303}.
uniprot
proteins
mass_dalton
48700
uniprot
proteins
mutagenesis
MUTAGEN 340; /note="Y->F: Reduces phosphorylation. Abolishes phosphorylation; when associated with F-350."; /evidence="ECO:0000269|PubMed:22303001, ECO:0000269|PubMed:9891087"; MUTAGEN 350; /note="Y->F: Reduces phosphorylation. Impairs podosome rosette formation. Abolishes phosphorylation; when associated with F-340."; /evidence="ECO:0000269|PubMed:22303001, ECO:0000269|PubMed:9891087
uniprot
proteins
protein_family
ABP1 family
uniprot
proteins
pubmed
10637315
uniprot
proteins
pubmed
11309416
uniprot
proteins
pubmed
12913069
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452483
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17476322
uniprot
proteins
pubmed
18829961
uniprot
proteins
pubmed
19064729
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22303001
uniprot
proteins
pubmed
23223303
uniprot
proteins
pubmed
9630982
uniprot
proteins
pubmed
9891087
uniprot
proteins
sequence_length
436
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10637315, ECO:0000269|PubMed:17476322, ECO:0000269|PubMed:9891087}. Cell projection, lamellipodium {ECO:0000269|PubMed:10637315, ECO:0000269|PubMed:12913069}. Cell projection, ruffle {ECO:0000269|PubMed:12913069}. Cytoplasm, cell cortex {ECO:0000269|PubMed:10637315, ECO:0000269|PubMed:11309416, ECO:0000269|PubMed:23223303}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JHL4}. Synapse {ECO:0000269|PubMed:11309416}. Perikaryon {ECO:0000269|PubMed:11309416}. Cell projection, neuron projection {ECO:0000269|PubMed:11309416}. Cell membrane {ECO:0000250|UniProtKB:Q9JHL4}; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000305|PubMed:11309416}; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane {ECO:0000269|PubMed:16452483}; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome {ECO:0000269|PubMed:22303001}. Early endosome {ECO:0000250|UniProtKB:Q9UJU6}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9JHL4}. Postsynaptic density {ECO:0000250|UniProtKB:Q9JHL4}. Note=Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes. {ECO:0000250|UniProtKB:Q9JHL4, ECO:0000269|PubMed:12913069, ECO:0000269|PubMed:17476322, ECO:0000269|PubMed:22303001}.
uniprot
proteins