Cfap70
entrez
76670
canonical
uniprot
D3YVL2
canonical
ensembl
ENSMUSG00000039543
resolver
ensp
ENSMUSP00000022348
resolver
ensp
ENSMUSP00000022349
resolver
ensp
ENSMUSP00000056869
resolver
genesymbol
Cfap70
resolver
genesymbol_syn
Ttc18
resolver
uniprot
B7ZNG2
resolver
uniprot
B7ZNG3
resolver
uniprot
D3Z1K9
resolver
uniprot
E9Q7X8
resolver
uniprot_entry
CFA70_MOUSE
resolver
uniprot_sec
B7ZNG2
resolver
uniprot_sec
B7ZNG3
resolver
uniprot_sec
D3Z1K9
resolver
uniprot_sec
E9Q7X8
resolver
amino_acid_sequence
MDQTSSTTKIVHITVTNGYDLKGFKGDTPVTFVRAEFNQTVLGDSSKVTVSPEGTAKYNFTSNIDLSPDGGGALDDLAHKPLFLTVTEVLPKEKKQKDEKTLILGQAVVDLLPLLEGEESFETTVPLHPVPGSPLETPLPGSKQCSLDVKVFVAEPLLTPAQVSASNLLKVTLEAAYSVPESFIPVGPQQNYMVGLQVPSVGEKDYTMIFKNGNLKLGGEKEPVPRPKKWPIANILAPGASNIPDEFIVGGPYEEEEGELNHPEDREFRNQAECTKKRIVWDLESRCFLHPFAVASFQKRIADCRLWPVEITRVPLVVMPKAKPGKLEKIDDENQLSFHGVAYINMVPLLYPGVKKIRGAFHVYPYLDGTVFEKTKCLFSLFRDTGHHLVQNNKAGGLNSPLSKPLSKNLKEEKPGKDKDTEGRPRLGELQAPSIKSQSSDTPLESEAPLSHNLEGQQYIEAGTYIVLEIQLEKALVPKRMPEELARRVKEMIPPRPPLTRRTGGAQKAVSDYHTQIKSISRAILNEYYRMFGKQGPKLESDIDNETMEERKCQLNYELNCSGKYFAFKEQLKHAVVKIVREKYLKTTAFESQEELQTFISELYVFLVDQMHVALNQAVPDDVPSSTSTIQTSSEQLRLFAFEAEVNEKFEIAAMYYEERLVREPQNLENWLDYGAFCLLTEDNIKAQECFRKALSLNESHVDSLLLCGVLAILLENYEQAEIFFEDATCLEPTNVIAWTLLGLFYEIQNNDIRMEMAFHEAFKQLQARTLQTKLKSTVTIENMEEGVKVEPSFGPWGVVQESTTAIKTEGLSGMRPQSSHQLSPHTNMELHPQPQGPNTALSSLDEFLEESPKAQSESQEPMATGQPLEPSLVQRSSNALLKELTSKKDISKCQDSSAFSPPTQHVIAQPPVTIFMETIRFLMKVNAVQFVHRVLAHELLCPQGGPSCEYYLVLAQTHLLKKDFAKTEEYLQQAAQMDYLNPNVWGVKGHLYFLSGNHAEAKECYERTISFVVDASEMHFIFLRLGHIYLEEKEYENAKRTYMHACKRSPSCLTWLGLGIACYRLEELTEAEDALSEANALNNCNAEVWAYLALVCLKVGRQLEAEQAYKYTIKLKLKDQALLEEIHTVQEMVGFGNPSF
uniprot
proteins
function
FUNCTION: Axoneme-binding protein that plays a role in the regulation of ciliary motility and cilium length (PubMed:30158508). Essential for the assembly of the sperm flagellum and the correct shaping of the sperm head, during spermiogenesis (PubMed:37458246, PubMed:37352829). Contributes in part to flagellar biogenesis by stabilizing QRICH2, promoting the cytoplasmic preassembly of CFAP61 and CFAP91, and regulating the manchette localization of axoneme-associated proteins such as IFT88, DNAI1 and CFAP61 (PubMed:37352829). {ECO:0000269|PubMed:30158508, ECO:0000269|PubMed:37352829, ECO:0000269|PubMed:37458246}.
uniprot
proteins
mass_dalton
128276
uniprot
proteins
protein_family
CFAP70 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30158508
uniprot
proteins
pubmed
37352829
uniprot
proteins
pubmed
37458246
uniprot
proteins
pubmed
39092789
uniprot
proteins
pubmed
39704931
uniprot
proteins
pubmed
39853433
uniprot
proteins
sequence_length
1141
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000269|PubMed:30158508, ECO:0000269|PubMed:37458246}. Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000250|UniProtKB:Q5T0N1}. Cell projection, cilium {ECO:0000269|PubMed:30158508}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:30158508}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:39092789}. Note=Present all along the flagellum, with a marked signal at the base of the flagellum (By similarity). Localizes to the central apparatus of the flagellar axoneme (PubMed:39853433). {ECO:0000250|UniProtKB:Q5T0N1, ECO:0000269|PubMed:39853433}.
uniprot
proteins