CIART
entrez
148523
canonical
uniprot
Q8N365
canonical
ensembl
ENSG00000159208
resolver
ensp
ENSP00000290363
resolver
ensp
ENSP00000358090
resolver
ensp
ENSP00000358091
resolver
ensp
ENSP00000398291
resolver
enst
ENST00000369094
resolver
genesymbol
C1orf51
resolver
genesymbol
CIART
resolver
genesymbol_syn
C1orf51
resolver
hgnc
HGNC:25200
resolver
uniprot
B2RD43
resolver
uniprot
D3DV01
resolver
uniprot
Q5TB12
resolver
uniprot
Q8N795
resolver
uniprot
Q8WVX4
resolver
uniprot
Q96MG6
resolver
uniprot_entry
CIART_HUMAN
resolver
uniprot_entry
Q5TB12_HUMAN
resolver
uniprot_entry
Q8WVX4_HUMAN
resolver
uniprot_sec
B2RD43
resolver
uniprot_sec
D3DV01
resolver
uniprot_sec
Q8N795
resolver
uniprot_sec
Q96MG6
resolver
amino_acid_sequence
MDSPSSVSSYSSYSLSSSFPTSPVNSDFGFPSDSEREDKGAHGPRPDTVGQRGGSRPSPGPIRCRHRSKVSGNQHTPSHPKQRGSASPMAGSGAKRSRDGELETSLNTQGCTTEGDLLFAQKCKELQGFIPPLTDLLNGLKMGRFERGLSSFQQSVAMDRIQRIVGVLQKPQMGERYLGTLLQVEGMLKTWFPQIAAQKSSLGGGKHQLTKHFPSHHSDSAASSPASPMEKMDQTQLGHLALKPKQPWHLTQWPAMNLTWIHTTPICNPPLSSPGTISFSHGPLGTGTGIGVILFLQHGVQPFTHSAPTTPVPPTTASPVIPGEPMKLSGEGPRCYSLPVTLPSDWSYTLSPPSLPTLARKMTIGHREQQRSHPPVAADAHLLNL
uniprot
proteins
function
FUNCTION: Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Abrogates the interaction of BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
41443
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
24385426
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Co-localizes with the CLOCK-BMAL1 heterodimer in the PML body. {ECO:0000250}.
uniprot
proteins