Cfd
entrez
11537
canonical
uniprot
P03953
canonical
ensembl
ENSMUSG00000061780
resolver
ensp
ENSMUSP00000056836
resolver
ensp
ENSMUSP00000151894
resolver
genesymbol
Cfd
resolver
genesymbol_syn
Adn
resolver
genesymbol_syn
Df
resolver
uniprot
B7ZNS9
resolver
uniprot
Q3UP47
resolver
uniprot
Q61280
resolver
uniprot_entry
B7ZNS9_MOUSE
resolver
uniprot_entry
CFAD_MOUSE
resolver
uniprot_entry
Q3UP47_MOUSE
resolver
uniprot_sec
Q61280
resolver
activity_regulation
ACTIVITY REGULATION: Circulates in plasma in a mature but self-inhibited form. Activated by factor B (CFB), which displaces the self-inhibition loop. Associates with CFB complexed with complement C3b. {ECO:0000250|UniProtKB:P00746}.
uniprot
proteins
amino_acid_sequence
MHSSVYFVALVILGAAVCAAQPRGRILGGQEAAAHARPYMASVQVNGTHVCGGTLLDEQWVLSAAHCMDGVTDDDSVQVLLGAHSLSAPEPYKRWYDVQSVVPHPGSRPDSLEDDLILFKLSQNASLGPHVRPLPLQYEDKEVEPGTLCDVAGWGVVTHAGRRPDVLHQLRVSIMNRTTCNLRTYHDGVVTINMMCAESNRRDTCRGDSGSPLVCGDAVEGVVTWGSRVCGNGKKPGVYTRVSSYRMWIENITNGNMTS
uniprot
proteins
ec_number
3.4.21.46
uniprot
proteins
function
FUNCTION: Serine protease that initiates the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. In contrast to other complement pathways (classical, lectin and GZMK) that are directly activated by pathogens or antigen-antibody complexes, the alternative complement pathway is initiated by the spontaneous hydrolysis of complement C3. The alternative complement pathway acts as an amplification loop that enhances complement activation by mediating the formation of C3 and C5 convertases. Activated CFD cleaves factor B (CFB) when the latter is complexed with complement C3b, activating the C3 convertase of the alternative pathway. {ECO:0000250|UniProtKB:P00746}.
uniprot
proteins
mass_dalton
28057
uniprot
proteins
post_translational_modification
PTM: CFD is activated by the removal of 5 residues at the N-terminus, named activation peptide, by the MASP-3 isoform of MASP1. {ECO:0000250|UniProtKB:P00746}.; PTM: N-glycosylated. {ECO:0000269|PubMed:16944957, ECO:0000269|PubMed:17330941}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
16944957
uniprot
proteins
pubmed
17330941
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
3015943
uniprot
proteins
pubmed
3024123
uniprot
proteins
pubmed
3901003
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P00746}.
uniprot
proteins