Ephb1
entrez
270190
canonical
uniprot
Q8CBF3
canonical
ensembl
ENSMUSG00000032537
resolver
ensp
ENSMUSP00000035129
resolver
ensp
ENSMUSP00000082261
resolver
ensp
ENSMUSP00000139470
resolver
enst
ENSMUST00000149800
resolver
genesymbol
Ephb1
resolver
uniprot
A0A087WNS3
resolver
uniprot
B1B1C2
resolver
uniprot
Q3UY27
resolver
uniprot
Q6PG23
resolver
uniprot
Q8CA63
resolver
uniprot
Q8CBE2
resolver
uniprot_entry
A0A087WNS3_MOUSE
resolver
uniprot_entry
EPHB1_MOUSE
resolver
uniprot_entry
Q8CA63_MOUSE
resolver
uniprot_sec
B1B1C2
resolver
uniprot_sec
Q3UY27
resolver
uniprot_sec
Q6PG23
resolver
uniprot_sec
Q8CBE2
resolver
amino_acid_sequence
MALDCLLLFLLASAVAAMEETLMDTRTATAELGWTANPASGWEEVSGYDENLNTIRTYQVCNVFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDYGACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYCNGDGEWMVPIGRCTCKPGYEPENSVACKACPAGTFKASQEAEGCSHCPSNSRSPSEASPICTCRTGYYRADFDPPEVACTSVPSGPRNVISIVNETSIILEWHPPRETGGRDDVTYNIICKKCRADRRSCSRCDDNVEFVPRQLGLTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPPQHVSVNITTNQAAPSTVPIMHQVSATMRSITLSWPQPEQPNGIILDYEIRYYEKEHNEFNSSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYGKFSGKMCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAAYSDKLQHYSTGRGSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGVTLAGHQKKILSSIHSMRVQMNQSPSVMA
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (PubMed:27446912). {ECO:0000269|PubMed:12971893, ECO:0000269|PubMed:14691139, ECO:0000269|PubMed:18057206, ECO:0000269|PubMed:18524895, ECO:0000269|PubMed:27446912}.
uniprot
proteins
mass_dalton
109881
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Autophosphorylation is stimulated by the ligand EFNB1. Required for interaction with SH2 domain-containing interactors, for activation of the MAPK/ERK and JUN signaling cascades and for ubiquitination by CBL (By similarity). {ECO:0000250|UniProtKB:P54762}.; PTM: Ubiquitinated; (EFNB1)ligand-induced poly- and/or multi-ubiquitination by CBL is regulated by SRC and leads to lysosomal degradation. {ECO:0000269|PubMed:18034775}.
uniprot
proteins
protein_family
Ephrin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
12223469
uniprot
proteins
pubmed
12925710
uniprot
proteins
pubmed
12971893
uniprot
proteins
pubmed
14691139
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034775
uniprot
proteins
pubmed
18057206
uniprot
proteins
pubmed
18524895
uniprot
proteins
pubmed
19025592
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27446912
uniprot
proteins
pubmed
9430661
uniprot
proteins
pubmed
9883737
uniprot
proteins
sequence_length
984
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P54762}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P54762}. Early endosome membrane {ECO:0000250|UniProtKB:P54762}. Cell projection, dendrite {ECO:0000269|PubMed:14691139}.
uniprot
proteins
transmembrane_region
TRANSMEM 541..563; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins