Twist1
entrez
22160
canonical
uniprot
P26687
canonical
ensembl
ENSMUSG00000035799
resolver
ensp
ENSMUSP00000040089
resolver
enst
ENSMUST00000049089
resolver
genesymbol
Twist1
resolver
genesymbol_syn
Twist
resolver
uniprot_entry
TWST1_MOUSE
resolver
amino_acid_sequence
MMQDVSSSPVSPADDSLSNSEEEPDRQQPASGKRGARKRRSSRRSAGGSAGPGGATGGGIGGGDEPGSPAQGKRGKKSAGGGGGGGAGGGGGGGGGSSSGGGSPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDELDSKMASCSYVAHERLSYAFSVWRMEGAWSMSASH
uniprot
proteins
function
FUNCTION: Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer. {ECO:0000269|PubMed:12553906, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:16502419, ECO:0000269|PubMed:17893140, ECO:0000269|PubMed:9343420}.
uniprot
proteins
mass_dalton
21198
uniprot
proteins
mutagenesis
MUTAGEN 179; /note="C->G: High transactivation activity."; /evidence="ECO:0000269|PubMed:17893140"; MUTAGEN 185; /note="E->D,K,R: High transactivation activity."; /evidence="ECO:0000269|PubMed:17893140"; MUTAGEN 186; /note="R->A,K: High transactivation activity."; /evidence="ECO:0000269|PubMed:17893140"; MUTAGEN 187; /note="L->G: Low transactivation activity."; /evidence="ECO:0000269|PubMed:17893140"; MUTAGEN 188; /note="S->A: High transactivation activity."; /evidence="ECO:0000269|PubMed:17893140"; MUTAGEN 191; /note="F->A,G,P: Low transactivation activity."; /evidence="ECO:0000269|PubMed:17893140"; MUTAGEN 192; /note="S->A: High transactivation activity."; /evidence="ECO:0000269|PubMed:17893140"; MUTAGEN 192; /note="S->P: Intermediate transactivation activity."; /evidence="ECO:0000269|PubMed:17893140"; MUTAGEN 195; /note="R->E: Intermediate transactivation activity."; /evidence="ECO:0000269|PubMed:17893140"; MUTAGEN 195; /note="R->G: Low transactivation activity."; /evidence="ECO:0000269|PubMed:17893140
uniprot
proteins
pubmed
12553906
uniprot
proteins
pubmed
14645221
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16502419
uniprot
proteins
pubmed
17893140
uniprot
proteins
pubmed
1840517
uniprot
proteins
pubmed
23395635
uniprot
proteins
pubmed
9343420
uniprot
proteins
sequence_length
206
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins