CUEDC2
entrez
79004
canonical
uniprot
Q9H467
canonical
ensembl
ENSG00000107874
resolver
ensp
ENSP00000358953
resolver
ensp
ENSP00000558837
resolver
ensp
ENSP00000558838
resolver
ensp
ENSP00000558839
resolver
ensp
ENSP00000558840
resolver
ensp
ENSP00000558842
resolver
ensp
ENSP00000595845
resolver
ensp
ENSP00000595846
resolver
ensp
ENSP00000595847
resolver
ensp
ENSP00000595852
resolver
ensp
ENSP00000595853
resolver
ensp
ENSP00000611492
resolver
enst
ENST00000369937
resolver
enst
ENST00000888778
resolver
enst
ENST00000888779
resolver
enst
ENST00000888780
resolver
enst
ENST00000888781
resolver
enst
ENST00000888783
resolver
enst
ENST00000925786
resolver
enst
ENST00000925787
resolver
enst
ENST00000925788
resolver
enst
ENST00000925793
resolver
enst
ENST00000925794
resolver
enst
ENST00000941433
resolver
genesymbol
CUEDC2
resolver
genesymbol_syn
C10orf66
resolver
hgnc
HGNC:28352
resolver
uniprot
D3DR88
resolver
uniprot
Q9BWG8
resolver
uniprot_entry
CUED2_HUMAN
resolver
uniprot_sec
D3DR88
resolver
uniprot_sec
Q9BWG8
resolver
amino_acid_sequence
MELERIVSAALLAFVQTHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFTEMMEAYVPGFAHIPRGTIGDMMQKLSGQLSDARNKENLQPQSSGVQGQVPISPEPLQRPEMLKEETRSSAAAAADTQDEATGAEEELLPGVDVLLEVFPTCSVEQAQWVLAKARGDLEEAVQMLVEGKEEGPAAWEGPNQDLPRRLRGPQKDELKSFILQKYMMVDSAEDQKIHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPEAEEMKATYINLKPARKYRFH
uniprot
proteins
disease_involvement
DISEASE: Note=May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression.
uniprot
proteins
function
FUNCTION: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. {ECO:0000269|PubMed:17347654, ECO:0000269|PubMed:21572428}.
uniprot
proteins
mass_dalton
32009
uniprot
proteins
protein_family
CUEDC2 family
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17347654
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21572428
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
287
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17347654}. Nucleus {ECO:0000269|PubMed:17347654}.
uniprot
proteins