IZUMO1
entrez
284359
canonical
uniprot
Q8IYV9
canonical
ensembl
ENSG00000182264
resolver
ensp
ENSP00000327786
resolver
genesymbol
IZUMO1
resolver
hgnc
HGNC:28539
resolver
uniprot
Q6Q8P6
resolver
uniprot
Q6Q8P7
resolver
uniprot_entry
IZUM1_HUMAN
resolver
uniprot_sec
Q6Q8P6
resolver
uniprot_sec
Q6Q8P7
resolver
amino_acid_sequence
MGPHFTLLCAALAGCLLPAEGCVICDPSVVLALKSLEKDYLPGHLDAKHHKAMMERVENAVKDFQELSLNEDAYMGVVDEATLQKGSWSLLKDLKRITDSDVKGDLFVKELFWMLHLQKETFATYVARFQKEAYCPNKCGVMLQTLIWCKNCKKEVHACRKSYDCGERNVEVPQMEDMILDCELNWHQASEGLTDYSFYRVWGNNTETLVSKGKEATLTKPMVGPEDAGSYRCELGSVNSSPATIINFHVTVLPKMIKEEKPSPNIVTPGEATTESSISLQPLQPEKMLASRLLGLLICGSLALITGLTFAIFRRRKVIDFIKSSLFGLGSGAAEQTQVPKEKATDSRQQ
uniprot
proteins
function
FUNCTION: Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Acts a ligand for the human-specific oolemma epitope FCRL3/MAIA during fertilization (PubMed:36070373). FCRL3/MAIA replaces IZUMO1R/JUNO as IZUMO1 receptor after sperm-egg adhesion, which permits species-specific gamete fusion (PubMed:36070373). Plays a critical role in sperm-oolemma binding prior to plasma membrane fusion. Can mediate cell-cell fusion in cultured mammalian cells independently of its binding to IZUMO1R/JUNO (By similarity). {ECO:0000250|UniProtKB:Q9D9J7, ECO:0000269|PubMed:36070373}.
uniprot
proteins
mass_dalton
38930
uniprot
proteins
mutagenesis
MUTAGEN 71; /note="E->A,K: Mildly decreases interaction with IZUMO1R."; /evidence="ECO:0000269|PubMed:27309818"; MUTAGEN 148; /note="W->A: Abolishes interaction with IZUMO1R."; /evidence="ECO:0000269|PubMed:27309818"; MUTAGEN 157; /note="H->A: Nearly abolishes interaction with IZUMO1R."; /evidence="ECO:0000269|PubMed:27309818"; MUTAGEN 160; /note="R->A,E: Nearly abolishes interaction with IZUMO1R."; /evidence="ECO:0000269|PubMed:27309818
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Glycosylation is not essential for fusion and for proper protein trafficking in sperm. {ECO:0000250|UniProtKB:Q9D9J7}.; PTM: Phosphorylated. The cytoplasmic C-terminus is phosphorylated and undergoes phosphorylation changes during epididymal transit. {ECO:0000250|UniProtKB:Q9D9J7}.
uniprot
proteins
protein_family
Izumo family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15759005
uniprot
proteins
pubmed
18082733
uniprot
proteins
pubmed
27309808
uniprot
proteins
pubmed
27309818
uniprot
proteins
pubmed
36070373
uniprot
proteins
pubmed
39423812
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15759005}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000269|PubMed:36070373}; Single-pass type I membrane protein {ECO:0000255}. Note=Localizes initially to the acrosome membrane of the sperm head (both outer and inner acrosomal membranes) (PubMed:36070373). During the acrosome reaction, translocates to the plasma membrane (PubMed:15759005, PubMed:36070373). {ECO:0000269|PubMed:15759005, ECO:0000269|PubMed:36070373}.
uniprot
proteins
transmembrane_region
TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins