S1pr2
entrez
29415
canonical
uniprot
P47752
canonical
ensembl
ENSRNOG00000020653
resolver
ensembl
ENSRNOG00055013081
resolver
ensembl
ENSRNOG00060027995
resolver
ensembl
ENSRNOG00065011906
resolver
ensp
ENSRNOP00000028034
resolver
ensp
ENSRNOP00000080559
resolver
ensp
ENSRNOP00000111338
resolver
ensp
ENSRNOP00055018159
resolver
ensp
ENSRNOP00060040523
resolver
ensp
ENSRNOP00065014767
resolver
enst
ENSRNOT00000028034
resolver
enst
ENSRNOT00000107018
resolver
enst
ENSRNOT00000137931
resolver
enst
ENSRNOT00055022387
resolver
enst
ENSRNOT00060048608
resolver
enst
ENSRNOT00065019323
resolver
genesymbol
S1pr2
resolver
genesymbol_syn
Edg5
resolver
uniprot
Q54AI6
resolver
uniprot_entry
S1PR2_RAT
resolver
uniprot_sec
Q54AI6
resolver
amino_acid_sequence
MGGLYSEYLNPEKVQEHYNYTKETLDMQETPSRKVASAFIIILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGPVTLSLTPLQWFAREGSAFITLSASVFSLLAIAIERQVAIAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCLDHLEACSTVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSSHADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVLRPLLCWRQGKGATGRRGGNPGHRLLPLRSSSSLERGLHMPTSPTFLEGNTVV
uniprot
proteins
function
FUNCTION: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10383399). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10383399). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (PubMed:29453251). In lymphoid follicles, couples the binding of S1P to the activation of GNA13 and downstream inhibition of AKT activation leading to suppression of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:O95136, ECO:0000269|PubMed:10383399, ECO:0000269|PubMed:29453251}.
uniprot
proteins
mass_dalton
38735
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10383399
uniprot
proteins
pubmed
29453251
uniprot
proteins
pubmed
8087418
uniprot
proteins
pubmed
8382486
uniprot
proteins
pubmed
9409733
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O95136}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..59; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 67..95; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 110..128; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 148..173; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 190..210; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 234..255; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 272..292; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins