Nr5a1
entrez
83826
canonical
uniprot
P50569
canonical
ensembl
ENSRNOG00055008558
resolver
ensembl
ENSRNOG00060027725
resolver
ensembl
ENSRNOG00065027467
resolver
ensp
ENSRNOP00055011557
resolver
ensp
ENSRNOP00060040032
resolver
ensp
ENSRNOP00065038836
resolver
enst
ENSRNOT00055014442
resolver
enst
ENSRNOT00060048106
resolver
enst
ENSRNOT00065047350
resolver
genesymbol
Nr5a1
resolver
genesymbol_syn
Ftzf1
resolver
uniprot_entry
STF1_RAT
resolver
amino_acid_sequence
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPPPDYMLPPSLHAPEPKALVSGPPSGPLGDFGAPSLPMAVPGPHGPLAGYLYPAFSNRTIKSEYPEPYASPPQQPGPPYSYPEPFSGGPNVPELILQLLQLEPEEDQVRARIVGCLQEPAKSRPDQPAPFSLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVLDHIYRQVQYGKEDSILLVTGQEVELSTVAVQAGSLLHSLVLRAQELVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSLVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
uniprot
proteins
function
FUNCTION: Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
52087
uniprot
proteins
post_translational_modification
PTM: Acetylation stimulates the transcriptional activity. {ECO:0000250}.; PTM: Sumoylation reduces CDK7-mediated phosphorylation on Ser-203. {ECO:0000250}.; PTM: Phosphorylated on Ser-203 by CDK7. This phosphorylation promotes transcriptional activity (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
NR5 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
7706291
uniprot
proteins
pubmed
8395654
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins