Fnbp1
entrez
192348
canonical
uniprot
Q8R511
canonical
ensembl
ENSRNOG00000008258
resolver
ensembl
ENSRNOG00055007214
resolver
ensembl
ENSRNOG00060032462
resolver
ensembl
ENSRNOG00065021290
resolver
ensp
ENSRNOP00000049838
resolver
ensp
ENSRNOP00000082158
resolver
ensp
ENSRNOP00000088096
resolver
ensp
ENSRNOP00000091155
resolver
ensp
ENSRNOP00000092158
resolver
enst
ENSRNOT00000096687
resolver
enst
ENSRNOT00000106082
resolver
genesymbol
Fnbp1
resolver
genesymbol_syn
Fbp17
resolver
uniprot
A0A8I6AD72
resolver
uniprot
A0A8I6GFT9
resolver
uniprot
Q75UE2
resolver
uniprot
Q75UE3
resolver
uniprot
Q75UE4
resolver
uniprot
Q75UE5
resolver
uniprot
Q75UE6
resolver
uniprot_entry
A0A8I6AD72_RAT
resolver
uniprot_entry
A0A8I6GFT9_RAT
resolver
uniprot_entry
FNBP1_RAT
resolver
uniprot_sec
Q75UE2
resolver
uniprot_sec
Q75UE3
resolver
uniprot_sec
Q75UE4
resolver
uniprot_sec
Q75UE5
resolver
uniprot_sec
Q75UE6
resolver
amino_acid_sequence
MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTACKAFLSTLNELNDYAGQHEVISENMTSQITVDLVRYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQMRQQMAEDSKADYSLILQRFNQEQWEYYHTHIPNIFQKIQEMEERRIVRIGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVVEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSSSKEGKPELKFGGKSRGKLWPFIKKNKLMTLLTSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGVTPEDFSNFPPEQRRKKLQQKVDDLNKEIQKETDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVTQNIEKLRLEAHKFEAWLAEVEGRLPARSEQARRQSGLYDGQTHQTVTNCAQDRESPDGSYTEEQSQESEHKVLATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLSVIEEDKGDGWTRIRRNEDEEGYVPTSYVEVYLDKNAKGS
uniprot
proteins
function
FUNCTION: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL (By similarity). May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Isoform 1 and isoform 2 promote RND2-induced neurite branching in neuronal cells. {ECO:0000250, ECO:0000269|PubMed:12244061, ECO:0000269|PubMed:14732713}.
uniprot
proteins
mass_dalton
71293
uniprot
proteins
mutagenesis
MUTAGEN 587; /note="W->A: Abrogates interaction with PDE6G."; /evidence="ECO:0000269|PubMed:14502124"; MUTAGEN 601; /note="P->L: Abrogates interaction with PDE6G."; /evidence="ECO:0000269|PubMed:14502124
uniprot
proteins
protein_family
FNBP1 family
uniprot
proteins
pubmed
12244061
uniprot
proteins
pubmed
14502124
uniprot
proteins
pubmed
14732713
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16357825
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
616
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cell cortex. Cytoplasm. Cytoplasmic vesicle {ECO:0000250}. Lysosome {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes. {ECO:0000250}.
uniprot
proteins