GCM1
entrez
8521
canonical
uniprot
Q9NP62
canonical
ensembl
ENSG00000137270
resolver
ensp
ENSP00000259803
resolver
enst
ENST00000259803
resolver
genesymbol
GCM1
resolver
genesymbol_syn
GCMA
resolver
hgnc
HGNC:4197
resolver
uniprot
Q4VAQ7
resolver
uniprot
Q5T0X0
resolver
uniprot
Q99468
resolver
uniprot
Q9P1X3
resolver
uniprot_entry
GCM1_HUMAN
resolver
uniprot_sec
Q4VAQ7
resolver
uniprot_sec
Q5T0X0
resolver
uniprot_sec
Q99468
resolver
uniprot_sec
Q9P1X3
resolver
amino_acid_sequence
MEPDDFDSEDKEILSWDINDVKLPQNVKKTDWFQEWPDSYAKHIYSSEDKNAQRHLSSWAMRNTNNHNSRILKKSCLGVVVCGRDCLAEEGRKIYLRPAICDKARQKQQRKRCPNCDGPLKLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPKPETKLEAEARRAMKKVNTAPSSVSLSLKGSTETRSLPGETQSQGSLPLTWSFQEGVQLPGSYSGHLIANTPQQNSLNDCFSFSKSYGLGGITDLTDQTSTVDPMKLYEKRKLSSSRTYSSGDLLPPSASGVYSDHGDLQAWSKNAALGRNHLADNCYSNYPFPLTSWPCSFSPSQNSSEPFYQQLPLEPPAAKTGCPPLWPNPAGNLYEEKVHVDFNSYVQSPAYHSPQEDPFLFTYASHPHQQYSLPSKSSKWDFEEEMTYLGLDHCNNDMLLNLCPLR
uniprot
proteins
function
FUNCTION: Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). {ECO:0000269|PubMed:10542267, ECO:0000269|PubMed:18160678, ECO:0000269|PubMed:19219068, ECO:0000269|PubMed:27917469}.
uniprot
proteins
mass_dalton
49268
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro). {ECO:0000269|PubMed:18703417}.
uniprot
proteins
pubmed
10542267
uniprot
proteins
pubmed
11071865
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18160678
uniprot
proteins
pubmed
18703417
uniprot
proteins
pubmed
19219068
uniprot
proteins
pubmed
27917469
uniprot
proteins
pubmed
8962155
uniprot
proteins
sequence_length
436
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00245}.
uniprot
proteins