Rapgef2
entrez
310533
canonical
uniprot
F1M386
canonical
ensembl
ENSRNOG00000021581
resolver
ensembl
ENSRNOG00055001378
resolver
ensembl
ENSRNOG00065031294
resolver
ensp
ENSRNOP00000098367
resolver
ensp
ENSRNOP00000100308
resolver
ensp
ENSRNOP00000101433
resolver
ensp
ENSRNOP00000105776
resolver
ensp
ENSRNOP00000107936
resolver
ensp
ENSRNOP00000108754
resolver
ensp
ENSRNOP00000109880
resolver
ensp
ENSRNOP00055001764
resolver
ensp
ENSRNOP00065044622
resolver
enst
ENSRNOT00000012792
resolver
enst
ENSRNOT00000120725
resolver
enst
ENSRNOT00000126958
resolver
enst
ENSRNOT00000136003
resolver
enst
ENSRNOT00000140490
resolver
enst
ENSRNOT00000166740
resolver
enst
ENSRNOT00055002294
resolver
enst
ENSRNOT00065054234
resolver
genesymbol
Rapgef2
resolver
genesymbol_syn
Pdzgef1
resolver
uniprot
A0ABK0KW23
resolver
uniprot
A0ABK0L6B5
resolver
uniprot
A0ABK0LDC2
resolver
uniprot
A0ABK0LHZ7
resolver
uniprot
A0ABK0LJJ5
resolver
uniprot
D3ZD17
resolver
uniprot_entry
A0ABK0KW23_RAT
resolver
uniprot_entry
A0ABK0L6B5_RAT
resolver
uniprot_entry
A0ABK0LDC2_RAT
resolver
uniprot_entry
A0ABK0LHZ7_RAT
resolver
uniprot_entry
A0ABK0LJJ5_RAT
resolver
uniprot_entry
RPGF2_RAT
resolver
uniprot_sec
D3ZD17
resolver
amino_acid_sequence
MKPLAAPANHGVLGQQEKQSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRSMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSSSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKTRISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPAALPVSGTLSSSNPDLLQSHHRILDFSTTPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCANLKKFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSANATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATSTLPKNPADRKPVKSETSPVAPRAGPQQKAQPQQPLAPPQPSHKVSQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHRKQAEDTISNASSQLSSPPTSPQSSPRKGYALALSGTVDNFSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVESNLGVGRMERRTLMEPDQYSLGSYAPVSESRGLYAAATVISSPSTEELSHDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHTHFDYSGDATGIWASGGHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSTEAESSSMVPVTTEEAKPVPMPAHIAVTPSTTKGLIARKEGRYREPPPTPPGYVGIPIADFPEGPCHPARKPPDYNVALQRSRMVARPTEAPAPGQTPPAATASRPGSKPQWHKPSDADPRLAPFQPQGFAGAEEDEDEQVSAV
uniprot
proteins
function
FUNCTION: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:17724123}.
uniprot
proteins
mass_dalton
166388
uniprot
proteins
mutagenesis
MUTAGEN 644; /note="T->A: Blocks the gel mobility shift induced by PLK2 and affects stimulation by PLK2; when associated with A-806; A-933; A-1022 and A-1175."; /evidence="ECO:0000269|PubMed:21382555"; MUTAGEN 806; /note="S->A: Blocks the gel mobility shift induced by PLK2 and affects stimulation by PLK2; when associated with A-644: A-933; A-1022 and A-1175."; /evidence="ECO:0000269|PubMed:21382555"; MUTAGEN 933; /note="S->A: Blocks the gel mobility shift induced by PLK2 and affects stimulation by PLK2; when associated with A-644; A-806; A-1022 and A-1175."; /evidence="ECO:0000269|PubMed:21382555"; MUTAGEN 1022; /note="S->A: Blocks the gel mobility shift induced by PLK2 and affects stimulation by PLK2; when associated with A-644; A-806; A-933 and A-1175."; /evidence="ECO:0000269|PubMed:21382555"; MUTAGEN 1175; /note="S->A: Blocks the gel mobility shift induced by PLK2 and affects stimulation by PLK2; when associated with A-644; A-806; A-933 and A-1022."; /evidence="ECO:0000269|PubMed:21382555
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by NEDD4, leading to proteasomal degradation. {ECO:0000250}.; PTM: Phosphorylation by PLK2 promotes its activity. {ECO:0000269|PubMed:21382555}.
uniprot
proteins
protein_family
RAPGEF2 family
uniprot
proteins
pubmed
10548487
uniprot
proteins
pubmed
10801446
uniprot
proteins
pubmed
10873669
uniprot
proteins
pubmed
12391161
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17724123
uniprot
proteins
pubmed
21382555
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:17724123}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Late endosome {ECO:0000250}. Cell junction {ECO:0000250}. Note=Associated with the synaptic plasma membrane. Localized diffusely in the cytoplasm before neuronal growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with the high affinity nerve growth factor receptor NTRK1 at late endosomes. Translocated to the perinuclear region in a RAP1A-dependent manner. Translocated to the cell membrane. Colocalized with CTNNB1 at cell-cell contacts (By similarity). Colocalizes with ADRB1 at the plasma membrane. Synaptosome. Enriched in synaptic plasma membrane and neuronal cell body. {ECO:0000250}.
uniprot
proteins