Celf1
entrez
13046
canonical
uniprot
P28659
canonical
ensembl
ENSMUSG00000005506
resolver
ensp
ENSMUSP00000005643
resolver
ensp
ENSMUSP00000064323
resolver
ensp
ENSMUSP00000070438
resolver
ensp
ENSMUSP00000107075
resolver
ensp
ENSMUSP00000107076
resolver
ensp
ENSMUSP00000107078
resolver
ensp
ENSMUSP00000107082
resolver
ensp
ENSMUSP00000136109
resolver
ensp
ENSMUSP00000210181
resolver
ensp
ENSMUSP00000210184
resolver
ensp
ENSMUSP00000210186
resolver
ensp
ENSMUSP00000210187
resolver
ensp
ENSMUSP00000210190
resolver
enst
ENSMUST00000068726
resolver
genesymbol
Celf1
resolver
genesymbol_syn
Brunol2
resolver
genesymbol_syn
Cugbp
resolver
genesymbol_syn
Cugbp1
resolver
uniprot
A0A0R4J0T5
resolver
uniprot
A2AFW9
resolver
uniprot
A2AFX0
resolver
uniprot
A2AFX1
resolver
uniprot
A2AFX2
resolver
uniprot
Q3U0N2
resolver
uniprot
Q3UP93
resolver
uniprot
Q3UY22
resolver
uniprot
Q8R532
resolver
uniprot
Q99PE1
resolver
uniprot
Q9CXE5
resolver
uniprot
Q9EPJ8
resolver
uniprot
Q9JI37
resolver
uniprot_entry
A0A0R4J0T5_MOUSE
resolver
uniprot_entry
CELF1_MOUSE
resolver
uniprot_sec
A2AFW9
resolver
uniprot_sec
A2AFX0
resolver
uniprot_sec
A2AFX1
resolver
uniprot_sec
A2AFX2
resolver
uniprot_sec
Q3U0N2
resolver
uniprot_sec
Q3UP93
resolver
uniprot_sec
Q3UY22
resolver
uniprot_sec
Q8R532
resolver
uniprot_sec
Q99PE1
resolver
uniprot_sec
Q9CXE5
resolver
uniprot_sec
Q9EPJ8
resolver
uniprot_sec
Q9JI37
resolver
amino_acid_sequence
MNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINILRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRTMAQTAIKAMHQAQTMEGCSSPMVVKFADTQKDKEQKRMAQQLQQQMQQISAASVWGNLAGLNTLGPQYLALYLQLLQQTASSGNLNTLSSLHPMGGLNAMQLQNLAALAAAASAAQNTPSGTNALTTSSSPLSVLTSSGSSPSSSSSNSVNPIASLGALQTLAGATAGLNVGSLAGMAALNGGLGSSGLSNGTGSTMEALTQAYSGIQQYAAAALPTLYNQNLLTQQSIGAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSKPY
uniprot
proteins
function
FUNCTION: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing (By similarity). Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition (By similarity). Acts both as an activator and a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs (By similarity). Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB (By similarity). Promotes exclusion of exon 11 of the INSR pre-mRNA (By similarity). Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast (By similarity). Increases translation and controls the choice of translation initiation codon of CEBPB mRNA (By similarity). Increases mRNA translation of CEBPB in aging liver. Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3 (By similarity). Mediates rapid cytoplasmic mRNA deadenylation (By similarity). Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation (By similarity). Required for completion of spermatogenesis. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs) (By similarity). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity). Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA (By similarity). Binds to the 5'-region of CDKN1A and CEBPB mRNAs (By similarity). Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (By similarity). {ECO:0000250|UniProtKB:Q92879, ECO:0000269|PubMed:15082764, ECO:0000269|PubMed:16931514, ECO:0000269|PubMed:17130239}.
uniprot
proteins
mass_dalton
52107
uniprot
proteins
mutagenesis
MUTAGEN 302; /note="S->G: Reduces CDK4-mediated phosphorylation."; /evidence="ECO:0000269|PubMed:16931514
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylated by CDK4 on Ser-302. Its phosphorylation status increases in aging liver and is important for the formation of the EIF2 complex and activation of CEBPB mRNA translation. Hyperphosphorylated in the EIF2 complex. EGFR signaling regulates its phosphorylation status in epithelial cells. {ECO:0000269|PubMed:15082764, ECO:0000269|PubMed:16931514}.
uniprot
proteins
protein_family
CELF/BRUNOL family
uniprot
proteins
pubmed
10893231
uniprot
proteins
pubmed
11158314
uniprot
proteins
pubmed
11686919
uniprot
proteins
pubmed
11707455
uniprot
proteins
pubmed
15082764
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15830352
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16931514
uniprot
proteins
pubmed
17130239
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
486
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=RNA-binding activity is detected in both nuclear and cytoplasmic compartments. {ECO:0000250}.
uniprot
proteins