Castor1
entrez
71962
canonical
uniprot
Q9CWQ8
canonical
ensembl
ENSMUSG00000020424
resolver
ensp
ENSMUSP00000020699
resolver
enst
ENSMUST00000020699
resolver
genesymbol
Castor1
resolver
genesymbol_syn
Gatsl3
resolver
uniprot
Q29R56
resolver
uniprot_entry
CAST1_MOUSE
resolver
uniprot_sec
Q29R56
resolver
amino_acid_sequence
MELHILEHRVRVLSIARPGLWLYTHPLIKLLFLPCRSRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVMNVSHSGSVVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAQEFQIYREVGGEPVPVTGDDSSNGFPQIQHGPSPTVHPIQSPQNRFCVLTLDPETLPAVATTLIDVLFYSHSVPKEAASGGPESTSIPFFAFSLIEGYISIVMDAEIQRKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAVDISAYYISTFNFDHALVPEDEIGCVIDILQRRQESQASKDP
uniprot
proteins
function
FUNCTION: Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. {ECO:0000250|UniProtKB:Q8WTX7}.
uniprot
proteins
mass_dalton
36575
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-14 by AKT1, promoting the interaction between CASTOR1 and RNF167. {ECO:0000250|UniProtKB:Q8WTX7}.; PTM: Ubiquitinated by RNF167 via 'Lys-29'-polyubiquitination, leading to its degradation, releasing the GATOR2 complex. Ubiquitination by RNF167 is promoted by phosphorylation at Ser-14 by AKT1. {ECO:0000250|UniProtKB:Q8WTX7}.
uniprot
proteins
protein_family
GATS family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8WTX7}.
uniprot
proteins