Mafk
entrez
17135
canonical
uniprot
Q61827
canonical
ensembl
ENSMUSG00000018143
resolver
ensp
ENSMUSP00000018287
resolver
ensp
ENSMUSP00000106460
resolver
enst
ENSMUST00000018287
resolver
enst
ENSMUST00000110836
resolver
genesymbol
Mafk
resolver
genesymbol_syn
Nfe2u
resolver
uniprot
Q3UP84
resolver
uniprot
Q60600
resolver
uniprot_entry
MAFK_MOUSE
resolver
uniprot_entry
Q3UP84_MOUSE
resolver
uniprot_sec
Q60600
resolver
amino_acid_sequence
MTTNPKPNKALKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVTPTKVATTSVITIVKSAELSSTSVPFSAAS
uniprot
proteins
function
FUNCTION: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (By similarity). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9240432). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (By similarity). {ECO:0000250|UniProtKB:O60675, ECO:0000269|PubMed:9240432}.
uniprot
proteins
mass_dalton
17537
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
Maf subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7706310
uniprot
proteins
pubmed
8265578
uniprot
proteins
pubmed
9240432
uniprot
proteins
sequence_length
156
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins