Neurl3
entrez
316326
canonical
uniprot
Q5M870
canonical
ensembl
ENSRNOG00000015366
resolver
ensembl
ENSRNOG00055019144
resolver
ensembl
ENSRNOG00060018411
resolver
ensembl
ENSRNOG00065011268
resolver
ensp
ENSRNOP00000029092
resolver
ensp
ENSRNOP00055026467
resolver
ensp
ENSRNOP00060025736
resolver
ensp
ENSRNOP00065013954
resolver
enst
ENSRNOT00000038610
resolver
enst
ENSRNOT00055032677
resolver
enst
ENSRNOT00060031680
resolver
enst
ENSRNOT00065018275
resolver
genesymbol
Neurl3
resolver
genesymbol_syn
Lincr
resolver
uniprot_entry
NEUL3_RAT
resolver
amino_acid_sequence
MGSRLSPEANAEVPREALSFHGDATGAQVHLDDQRSTARRRSTFHDGIVFSQRPVWPGERVALRVLRHEDGWCGGLRVGFTRLDPAQVAASCLPPFVCPDLEEQSPTWAALLPEGFVRAGNVVCFWVNRRGWLFAKVNAGRPLLLRKDVLVQGAPLWAVMDVYGTTKAIELLDPKANAWITSGEPMPESEVTSGEECVICFHNTANTRLMPCGHSQFCGSCAWHIFKDTARCPMCRWQIEEVAVEPSVKSGEGS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity. Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7. Also inhibits hepatitis C virus assembly by directly binding to viral E1 envelope glycoprotein to disrupt its interaction with E2. Plays an essential role in TLR4-mediated activation of MAPK pathways by promoting 'Lys-48'-linked polyubiquitination of the phosphatase DUSP1/MKP1. {ECO:0000250|UniProtKB:Q96EH8}.
uniprot
proteins
mass_dalton
28014
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96EH8}.
uniprot
proteins