HLA-DQB2
entrez
3120
canonical
uniprot
P05538
canonical
ensembl
ENSG00000196610
resolver
ensembl
ENSG00000224305
resolver
ensembl
ENSG00000226165
resolver
ensembl
ENSG00000228254
resolver
ensembl
ENSG00000228813
resolver
ensembl
ENSG00000229493
resolver
ensembl
ENSG00000230675
resolver
ensembl
ENSG00000232629
resolver
ensp
ENSP00000322293
resolver
ensp
ENSP00000382569
resolver
ensp
ENSP00000387578
resolver
ensp
ENSP00000388849
resolver
ensp
ENSP00000389067
resolver
ensp
ENSP00000390431
resolver
ensp
ENSP00000391938
resolver
ensp
ENSP00000392299
resolver
ensp
ENSP00000394272
resolver
ensp
ENSP00000394759
resolver
ensp
ENSP00000396330
resolver
ensp
ENSP00000396502
resolver
ensp
ENSP00000406872
resolver
ensp
ENSP00000409159
resolver
ensp
ENSP00000410132
resolver
ensp
ENSP00000410512
resolver
ensp
ENSP00000415997
resolver
ensp
ENSP00000416466
resolver
ensp
ENSP00000540980
resolver
enst
ENST00000323109
resolver
enst
ENST00000399661
resolver
enst
ENST00000415137
resolver
enst
ENST00000419519
resolver
enst
ENST00000419685
resolver
enst
ENST00000429783
resolver
enst
ENST00000430668
resolver
enst
ENST00000430849
resolver
enst
ENST00000432486
resolver
enst
ENST00000433801
resolver
enst
ENST00000435145
resolver
enst
ENST00000437316
resolver
enst
ENST00000442043
resolver
enst
ENST00000442806
resolver
enst
ENST00000455520
resolver
enst
ENST00000457432
resolver
genesymbol
HLA-DQB2
resolver
genesymbol_syn
HLA-DXB
resolver
hgnc
HGNC:4945
resolver
uniprot
A0A0G2JH31
resolver
uniprot
A2ADX3
resolver
uniprot
A6NIA5
resolver
uniprot
B3KUV1
resolver
uniprot
Q29826
resolver
uniprot
Q29870
resolver
uniprot
Q29871
resolver
uniprot
Q29872
resolver
uniprot
Q29873
resolver
uniprot
Q5SR05
resolver
uniprot
Q5SR06
resolver
uniprot_entry
A0A0G2JH31_HUMAN
resolver
uniprot_entry
A2ADX3_HUMAN
resolver
uniprot_entry
B3KUV1_HUMAN
resolver
uniprot_entry
DQB2_HUMAN
resolver
uniprot_entry
Q5SR05_HUMAN
resolver
uniprot_sec
A6NIA5
resolver
uniprot_sec
Q29826
resolver
uniprot_sec
Q29870
resolver
uniprot_sec
Q29871
resolver
uniprot_sec
Q29872
resolver
uniprot_sec
Q29873
resolver
uniprot_sec
Q5SR06
resolver
amino_acid_sequence
MSWKMALQIPGGFWAAAVTVMLVMLSTPVAEARDFPKDFLVQFKGMCYFTNGTERVRGVARYIYNREEYGRFDSDVGEFQAVTELGRSIEDWNNYKDFLEQERAAVDKVCRHNYEAELRTTLQRQVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRNDQEETAGVVSTSLIRNGDWTFQILVMLEITPQRGDIYTCQVEHPSLQSPITVEWRAQSESAQSKMLSGIGGFVLGLIFLGLGLIIRHRGQKGPRGPPPAGLLH
uniprot
proteins
function
FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. {ECO:0000269|PubMed:22407913}.
uniprot
proteins
mass_dalton
30387
uniprot
proteins
protein_family
MHC class II family
uniprot
proteins
pubmed
11334674
uniprot
proteins
pubmed
11684289
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17241953
uniprot
proteins
pubmed
18046453
uniprot
proteins
pubmed
19092054
uniprot
proteins
pubmed
19533806
uniprot
proteins
pubmed
22407913
uniprot
proteins
pubmed
2564844
uniprot
proteins
pubmed
3036828
uniprot
proteins
pubmed
3858830
uniprot
proteins
pubmed
8568858
uniprot
proteins
pubmed
8598037
uniprot
proteins
pubmed
9036956
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Lysosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
uniprot
proteins
transmembrane_region
TRANSMEM 230..250; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins