ADIPOR2
entrez
79602
canonical
uniprot
Q86V24
canonical
ensembl
ENSG00000006831
resolver
ensembl
ENSG00000285070
resolver
ensp
ENSP00000349616
resolver
ensp
ENSP00000495699
resolver
ensp
ENSP00000549022
resolver
ensp
ENSP00000549023
resolver
ensp
ENSP00000549024
resolver
ensp
ENSP00000549025
resolver
ensp
ENSP00000549027
resolver
ensp
ENSP00000549028
resolver
ensp
ENSP00000549029
resolver
ensp
ENSP00000549032
resolver
ensp
ENSP00000549034
resolver
ensp
ENSP00000549035
resolver
ensp
ENSP00000549040
resolver
ensp
ENSP00000549041
resolver
ensp
ENSP00000549042
resolver
ensp
ENSP00000549043
resolver
ensp
ENSP00000549044
resolver
ensp
ENSP00000549047
resolver
ensp
ENSP00000549050
resolver
ensp
ENSP00000549052
resolver
ensp
ENSP00000549053
resolver
ensp
ENSP00000549054
resolver
ensp
ENSP00000549055
resolver
ensp
ENSP00000594935
resolver
ensp
ENSP00000594937
resolver
ensp
ENSP00000663549
resolver
ensp
ENSP00000663550
resolver
enst
ENST00000357103
resolver
enst
ENST00000645126
resolver
enst
ENST00000878963
resolver
enst
ENST00000878965
resolver
enst
ENST00000878966
resolver
enst
ENST00000878968
resolver
enst
ENST00000878969
resolver
enst
ENST00000878970
resolver
enst
ENST00000878973
resolver
enst
ENST00000878975
resolver
enst
ENST00000878976
resolver
enst
ENST00000878981
resolver
enst
ENST00000878982
resolver
enst
ENST00000878983
resolver
enst
ENST00000878984
resolver
enst
ENST00000878985
resolver
enst
ENST00000878988
resolver
enst
ENST00000878991
resolver
enst
ENST00000878993
resolver
enst
ENST00000878994
resolver
enst
ENST00000878995
resolver
enst
ENST00000878996
resolver
enst
ENST00000924876
resolver
enst
ENST00000924878
resolver
genesymbol
ADIPOR2
resolver
genesymbol_syn
PAQR2
resolver
hgnc
HGNC:24041
resolver
uniprot
Q53YY5
resolver
uniprot
Q9H737
resolver
uniprot_entry
PAQR2_HUMAN
resolver
uniprot_sec
Q53YY5
resolver
uniprot_sec
Q9H737
resolver
amino_acid_sequence
MNEPTENRLGCSRTPEPDIRLRKGHQLDGTRRGDNDSHQGDLEPILEASVLSSHHKKSSEEHEYSDEAPQEDEGFMGMSPLLQAHHAMEKMEEFVCKVWEGRWRVIPHDVLPDWLKDNDFLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGCVFFLCLGIFYMFRPNISFVAPLQEKVVFGLFFLGAILCLSFSWLFHTVYCHSEGVSRLFSKLDYSGIALLIMGSFVPWLYYSFYCNPQPCFIYLIVICVLGIAAIIVSQWDMFATPQYRGVRAGVFLGLGLSGIIPTLHYVISEGFLKAATIGQIGWLMLMASLYITGAALYAARIPERFFPGKCDIWFHSHQLFHIFVVAGAFVHFHGVSNLQEFRFMIGGGCSEEDAL
uniprot
proteins
function
FUNCTION: Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity). {ECO:0000250|UniProtKB:Q8BQS5, ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}.
uniprot
proteins
mass_dalton
43884
uniprot
proteins
mutagenesis
MUTAGEN 202; /note="H->A: Abolishes response to ADIPOQ binding; when associated with A-219; A-348 and A-352."; /evidence="ECO:0000269|PubMed:25855295"; MUTAGEN 219; /note="D->A: Impairs response to ADIPOQ binding. Abolishes response to ADIPOQ binding; when associated with A-202; A-348 and A-352."; /evidence="ECO:0000269|PubMed:25855295"; MUTAGEN 348; /note="H->A: Impairs response to ADIPOQ binding. Abolishes response to ADIPOQ binding; when associated with A-202; A-219 and A-352."; /evidence="ECO:0000269|PubMed:25855295"; MUTAGEN 352; /note="H->A: Abolishes response to ADIPOQ binding; when associated with A-202; A-219 and A-348."; /evidence="ECO:0000269|PubMed:25855295
uniprot
proteins
protein_family
ADIPOR family
uniprot
proteins
pubmed
12802337
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16044242
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25855295
uniprot
proteins
pubmed
25969726
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}; Multi-pass membrane protein {ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}. Note=Localized to the cell membrane and intracellular organelles. {ECO:0000269|PubMed:12802337}.
uniprot
proteins
transmembrane_region
TRANSMEM 148..168; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:25855295"; TRANSMEM 182..202; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:25855295"; TRANSMEM 214..234; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:25855295"; TRANSMEM 246..266; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:25855295"; TRANSMEM 274..294; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:25855295"; TRANSMEM 310..330; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:25855295"; TRANSMEM 349..369; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:25855295
uniprot
proteins