PLPP4
entrez
196051
canonical
uniprot
Q5VZY2
canonical
ensembl
ENSG00000203805
resolver
ensp
ENSP00000381302
resolver
ensp
ENSP00000648107
resolver
ensp
ENSP00000679570
resolver
ensp
ENSP00000765303
resolver
ensp
ENSP00000789912
resolver
ensp
ENSP00000789913
resolver
genesymbol
PLPP4
resolver
genesymbol_syn
DPPL2
resolver
genesymbol_syn
PPAPDC1
resolver
genesymbol_syn
PPAPDC1A
resolver
hgnc
HGNC:23531
resolver
uniprot
A2RU82
resolver
uniprot
Q08EQ2
resolver
uniprot
Q0IIP2
resolver
uniprot
Q495B4
resolver
uniprot
Q5VZY1
resolver
uniprot_entry
PLPP4_HUMAN
resolver
uniprot_sec
A2RU82
resolver
uniprot_sec
Q08EQ2
resolver
uniprot_sec
Q0IIP2
resolver
uniprot_sec
Q495B4
resolver
uniprot_sec
Q5VZY1
resolver
activity_regulation
ACTIVITY REGULATION: Magnesium-independent phospholipid phosphatase (PubMed:17590538). Inhibited by N-ethylmaleimide (PubMed:17590538). {ECO:0000269|PubMed:17590538}.
uniprot
proteins
amino_acid_sequence
MRELAIEIGVRALLFGVFVFTEFLDPFQRVIQPEEIWLYKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIKLIVGRPRPDFFYRCFPDGVMNSEMHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTESGRGKSWRLCAAILPLYCAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICYRQHYPPLANTACHKPYVSLRVPASLKKEERPTADSAPSLPLEGITEGPV
uniprot
proteins
ec_number
3.1.3.4
uniprot
proteins
ec_number
3.6.1.75
uniprot
proteins
function
FUNCTION: Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the degradation or generation of lipid-signaling molecules like diacylglycerol (PubMed:28851360). {ECO:0000269|PubMed:17590538, ECO:0000269|PubMed:28851360}.
uniprot
proteins
mass_dalton
30395
uniprot
proteins
mutagenesis
MUTAGEN 109; /note="R->A: Loss of phosphatase activity; when associated with A-146 and with A-202."; /evidence="ECO:0000269|PubMed:17590538"; MUTAGEN 146; /note="H->A: Loss of phosphatase activity; when associated with A-109 and with A-202."; /evidence="ECO:0000269|PubMed:17590538"; MUTAGEN 202; /note="H->A: Loss of phosphatase activity; when associated with A-109 and with A-146."; /evidence="ECO:0000269|PubMed:17590538
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000269|PubMed:17590538}.
uniprot
proteins
protein_family
PA-phosphatase related phosphoesterase family
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17590538
uniprot
proteins
pubmed
28851360
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:17590538}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins