PTGR1
entrez
22949
canonical
uniprot
Q14914
canonical
ensembl
ENSG00000106853
resolver
ensp
ENSP00000311572
resolver
ensp
ENSP00000385763
resolver
ensp
ENSP00000435665
resolver
ensp
ENSP00000440281
resolver
ensp
ENSP00000655344
resolver
ensp
ENSP00000655376
resolver
ensp
ENSP00000698954
resolver
ensp
ENSP00000698970
resolver
enst
ENST00000466771
resolver
genesymbol
PTGR1
resolver
genesymbol_syn
LTB4DH
resolver
hgnc
HGNC:18429
resolver
uniprot
A8K0N2
resolver
uniprot
B4DPK3
resolver
uniprot
F2Z3J9
resolver
uniprot
F5GY50
resolver
uniprot
Q8IYQ0
resolver
uniprot
Q9H1X6
resolver
uniprot_entry
F2Z3J9_HUMAN
resolver
uniprot_entry
PTGR1_HUMAN
resolver
uniprot_sec
A8K0N2
resolver
uniprot_sec
B4DPK3
resolver
uniprot_sec
F5GY50
resolver
uniprot_sec
Q8IYQ0
resolver
uniprot_sec
Q9H1X6
resolver
amino_acid_sequence
MVRTKTWTLKKHFVGYPTNSDFELKTAELPPLKNGEVLLEALFLTVDPYMRVAAKRLKEGDTMMGQQVAKVVESKNVALPKGTIVLASPGWTTHSISDGKDLEKLLTEWPDTIPLSLALGTVGMPGLTAYFGLLEICGVKGGETVMVNAAAGAVGSVVGQIAKLKGCKVVGAVGSDEKVAYLQKLGFDVVFNYKTVESLEETLKKASPDGYDCYFDNVGGEFSNTVIGQMKKFGRIAICGAISTYNRTGPLPPGPPPEIVIYQELRMEAFVVYRWQGDARQKALKDLLKWVLEGKIQYKEYIIEGFENMPAAFMGMLKGDNLGKTIVKA
uniprot
proteins
ec_number
1.3.1.48
uniprot
proteins
ec_number
1.3.1.74
uniprot
proteins
function
FUNCTION: NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:25619643). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:25619643). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity) (PubMed:25619643). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:25619643). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity). {ECO:0000250|UniProtKB:P97584, ECO:0000250|UniProtKB:Q29073, ECO:0000269|PubMed:25619643}.
uniprot
proteins
mass_dalton
35870
uniprot
proteins
mutagenesis
MUTAGEN 56; /note="R->A: Markedly decreases the catalytic efficiency toward 15-oxoprostaglandin E2."; /evidence="ECO:0000269|PubMed:25619643"; MUTAGEN 245; /note="Y->A,F: Markedly decreases the catalytic efficiency toward 15-oxoprostaglandin E2 and (3E)-3-nonen-2-one."; /evidence="ECO:0000269|PubMed:25619643
uniprot
proteins
protein_family
NADP-dependent oxidoreductase L4BD family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25619643
uniprot
proteins
pubmed
29192674
uniprot
proteins
pubmed
8576264
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q29073}.
uniprot
proteins