APOBEC3B
entrez
9582
canonical
uniprot
Q9UH17
canonical
ensembl
ENSG00000179750
resolver
ensp
ENSP00000327459
resolver
ensp
ENSP00000385068
resolver
genesymbol
APOBEC3B
resolver
hgnc
HGNC:17352
resolver
uniprot
B0QYD2
resolver
uniprot
O95618
resolver
uniprot
Q20WL1
resolver
uniprot
Q5IFJ4
resolver
uniprot
Q7Z2N3
resolver
uniprot
Q7Z6D6
resolver
uniprot
Q9UE74
resolver
uniprot_entry
ABC3B_HUMAN
resolver
uniprot_sec
B0QYD2
resolver
uniprot_sec
O95618
resolver
uniprot_sec
Q20WL1
resolver
uniprot_sec
Q5IFJ4
resolver
uniprot_sec
Q7Z2N3
resolver
uniprot_sec
Q7Z6D6
resolver
uniprot_sec
Q9UE74
resolver
amino_acid_sequence
MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVYFKPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVTIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGTWVLMDQHMGFLCNEAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYRQGCPFQPWDGLEEHSQALSGRLRAILQNQGN
uniprot
proteins
disease_involvement
DISEASE: Note=In the urothelium, antiviral activity of APOBEC3A and APOBEC3B against BK polyomavirus (BKPyV) drives a high burden of mutations in cells proximal to infected neighbors (transmutagenesis), and may be involved in urothelial carcinogenesis. {ECO:0000269|PubMed:41337590}.
uniprot
proteins
ec_number
3.5.4.38
uniprot
proteins
function
FUNCTION: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. {ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:15466872, ECO:0000269|PubMed:16060832, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:22457529}.
uniprot
proteins
mass_dalton
45924
uniprot
proteins
protein_family
Cytidine and deoxycytidylate deaminase family
uniprot
proteins
pubmed
10469298
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11863358
uniprot
proteins
pubmed
12683974
uniprot
proteins
pubmed
12859895
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15466872
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16060832
uniprot
proteins
pubmed
16527742
uniprot
proteins
pubmed
16699599
uniprot
proteins
pubmed
17020885
uniprot
proteins
pubmed
18304004
uniprot
proteins
pubmed
18448976
uniprot
proteins
pubmed
18667511
uniprot
proteins
pubmed
20062055
uniprot
proteins
pubmed
20308164
uniprot
proteins
pubmed
21835787
uniprot
proteins
pubmed
22001110
uniprot
proteins
pubmed
22457529
uniprot
proteins
pubmed
22912627
uniprot
proteins
pubmed
22915799
uniprot
proteins
pubmed
41337590
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16699599, ECO:0000269|PubMed:18667511, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22915799}.
uniprot
proteins