Jmy
entrez
57748
canonical
uniprot
Q9QXM1
canonical
ensembl
ENSMUSG00000021690
resolver
ensp
ENSMUSP00000070339
resolver
enst
ENSMUST00000065537
resolver
genesymbol
Jmy
resolver
uniprot
A0A0R4J0V4
resolver
uniprot
Q3UQZ0
resolver
uniprot
Q5BL16
resolver
uniprot
Q6NST0
resolver
uniprot
Q8CBP9
resolver
uniprot
Q8VDZ3
resolver
uniprot_entry
A0A0R4J0V4_MOUSE
resolver
uniprot_entry
JMY_MOUSE
resolver
uniprot_sec
Q3UQZ0
resolver
uniprot_sec
Q5BL16
resolver
uniprot_sec
Q6NST0
resolver
uniprot_sec
Q8CBP9
resolver
uniprot_sec
Q8VDZ3
resolver
amino_acid_sequence
MSFALEETLESDWVAVRPHVFDEREKHKFVFIVAWNEIEGKFAITCHNRTAQRQRSGSREQAGTPASDGSRGPGSPAARGRSEAAASATAALRSPGPRKSQAWAEGGSPRSARSLKGDPPRGPAGRGPESPLRSPARAKASPLRRSAESRDAIASATPVPPAPPVPPVSSVRVVSASGAVSEEIEVLEMVREDEAPQPLPDSEQPPSAAELESSAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPSGMWTVLFGGAPEMTEQEIDALCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYYESLSELRQKGYEEVLQRARRRIQELLDKHKTIESMVELLDLYQMEDEAYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQKKHALKEEMQSLQGGTEAIARLDQLESDYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASVHAQREELQKLQQKARQLEARRGRVSAKKAYLRNKKEICIAKHHEKFQQRFQSEDEYRAHHTIQIKRDKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRVAHSRRKSTASPVPCEEQCHSLPTVLQGQEKTEVGGGGSQLGPSQTAEPQSLVQLEDTSSEQLESTSLPPRAVVSSELPPPQSAPLLTSIDPKPCSVTIDPLPPPLPPTPPPPPPPPPPPPPPLPVAKDNGASTTAETLEKDALRTEGNERSIPKSASAPAAHLFDSSQLVSARKKLRKTVEGLQRRRVSSPMDEVLASLKRGSFHLKKVEQRTLPPFPDEDDSNNILAQIRKGVKLKKVQKEVLRESFTLLPDTDPLTRSIHEALRRIKEASPESEDEEEALPCTDWEN
uniprot
proteins
function
FUNCTION: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (By similarity). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location. {ECO:0000250|UniProtKB:Q8N9B5, ECO:0000269|PubMed:10518217, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:19287377, ECO:0000269|PubMed:19897726}.
uniprot
proteins
mass_dalton
110586
uniprot
proteins
mutagenesis
MUTAGEN 981; /note="W->A: Decreases the activation of Arp2/3 without affecting the intrinsic nucleation activity."; /evidence="ECO:0000269|PubMed:19287377
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response. {ECO:0000269|PubMed:17170761}.
uniprot
proteins
protein_family
JMY family
uniprot
proteins
pubmed
10518217
uniprot
proteins
pubmed
11511361
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17170761
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19287377
uniprot
proteins
pubmed
19897726
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
983
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19287377, ECO:0000269|PubMed:19897726}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q8N9B5}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8N9B5}. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q8N9B5}. Note=Localizes to the nucleus in most cell types. In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil-like cells (By similarity). Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility. Localizes to cytoplasmic vesicles which associate with actin filament and autophagosomal membranes upon starvation-induced autophagy (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q8N9B5}.
uniprot
proteins