Tmco1
entrez
68944
canonical
uniprot
Q921L3
canonical
ensembl
ENSMUSG00000052428
resolver
ensp
ENSMUSP00000095081
resolver
ensp
ENSMUSP00000142042
resolver
enst
ENSMUST00000097473
resolver
enst
ENSMUST00000195015
resolver
genesymbol
Tmco1
resolver
uniprot
Q3TS11
resolver
uniprot
Q3V4A0
resolver
uniprot_entry
Q3V4A0_MOUSE
resolver
uniprot_entry
TMCO1_MOUSE
resolver
uniprot_sec
Q3TS11
resolver
amino_acid_sequence
MSTMFADTLLIVFISVCTALLAEGITWVLVYRTDKYKRLKAEVEKQSKKLEKKKETITESAGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAGGFLGPPPPSGKFS
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER) calcium-selective channel preventing intracellular Ca2(+) stores from overfilling and maintaining calcium homeostasis in the ER. In response to endoplasmic reticulum (ER) Ca2(+) overloading, assembles into a homotetramer, forming a functional calcium-selective channel facilitating Ca2(+) release (PubMed:27212239, PubMed:29467381, PubMed:30962442). Mediates ER Ca2(+) homeostasis in osteoblasts and plays a key role in bone formation, via the CaMKII-HDAC4-RUNX2 signaling axis (PubMed:30962442). Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (By similarity). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (By similarity). {ECO:0000250|UniProtKB:Q9UM00, ECO:0000269|PubMed:27212239, ECO:0000269|PubMed:29467381, ECO:0000269|PubMed:30962442}.
uniprot
proteins
mass_dalton
21175
uniprot
proteins
protein_family
TMCO1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27212239
uniprot
proteins
pubmed
29467381
uniprot
proteins
pubmed
30962442
uniprot
proteins
sequence_length
188
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UM00}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UM00}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9UM00}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UM00}. Mitochondrion membrane {ECO:0000250|UniProtKB:C5HGF3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UM00}. Note=The first transmembrane region is required for localization to the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q9UM00}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..32; /note="Helical"; /evidence="ECO:0000250|UniProtKB:A0A8I3PI99"; TRANSMEM 87..106; /note="Helical"; /evidence="ECO:0000250|UniProtKB:A0A8I3PI99"; TRANSMEM 141..162; /note="Helical"; /evidence="ECO:0000250|UniProtKB:A0A8I3PI99
uniprot
proteins