Pcyt1a
entrez
140544
canonical
uniprot
P19836
canonical
ensembl
ENSRNOG00000001762
resolver
ensembl
ENSRNOG00055017520
resolver
ensembl
ENSRNOG00060024455
resolver
ensembl
ENSRNOG00065020895
resolver
ensp
ENSRNOP00000002403
resolver
ensp
ENSRNOP00055023801
resolver
ensp
ENSRNOP00060035139
resolver
ensp
ENSRNOP00065028589
resolver
enst
ENSRNOT00000002403
resolver
enst
ENSRNOT00055029639
resolver
enst
ENSRNOT00060042408
resolver
enst
ENSRNOT00065035485
resolver
genesymbol
Pcyt1a
resolver
genesymbol_syn
Ctpct
resolver
genesymbol_syn
Pcyt1
resolver
uniprot_entry
PCY1A_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Interconverts between an inactive cytosolic form and an active membrane-bound form (PubMed:24275660). Activation involves disruption of an inhibitory interaction between helices at the base of the active site and the autoinhibitory (AI) region (PubMed:24275660). Activated by N-methylethanolamine (PubMed:8185307). Activated by oleic acid-containing phosphatidylcholine vesicles (PubMed:8381041). {ECO:0000269|PubMed:24275660, ECO:0000269|PubMed:8185307, ECO:0000269|PubMed:8381041}.
uniprot
proteins
amino_acid_sequence
MDAQSSAKVNSRKRRKEVPGPNGATEEDGIPSKVQRCAVGLRQPAPFSDEIEVDFSKPYVRVTMEEACRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSSPTHERSPSPSFRWPFSGKTSPSSSPASLSRCKAVTCDISEDEED
uniprot
proteins
ec_number
2.7.7.15
uniprot
proteins
function
FUNCTION: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:12718547, ECO:0000269|PubMed:19783652, ECO:0000269|PubMed:2166941, ECO:0000269|PubMed:24275660, ECO:0000269|PubMed:639816, ECO:0000269|PubMed:8185307, ECO:0000269|PubMed:8381041}.
uniprot
proteins
mass_dalton
41681
uniprot
proteins
mutagenesis
MUTAGEN 122; /note="K->A: Nearly abolishes enzyme activity. Decreases affinity for phosphocholine about 500-fold."; /evidence="ECO:0000269|PubMed:12718547"; MUTAGEN 122; /note="K->R: Nearly abolishes enzyme activity. Decreases affinity for phosphocholine about 80-fold."; /evidence="ECO:0000269|PubMed:12718547"; MUTAGEN 168; /note="H->A: Strongly reduced catalytic activity."; /evidence="ECO:0000269|PubMed:19783652"; MUTAGEN 173; /note="Y->A: Reduced catalytic activity. Reduces affinity for phosphocholine."; /evidence="ECO:0000269|PubMed:19783652"; MUTAGEN 362; /note="S->A,C: No loss of enzyme activity and nuclear localization."; /evidence="ECO:0000269|PubMed:8185307
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2. {ECO:0000269|PubMed:12718547, ECO:0000269|PubMed:19783652, ECO:0000269|PubMed:2166941, ECO:0000269|PubMed:24275660, ECO:0000269|PubMed:639816, ECO:0000269|PubMed:8185307, ECO:0000269|PubMed:8381041}.
uniprot
proteins
post_translational_modification
PTM: The serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation. {ECO:0000269|PubMed:8144639}.; PTM: The N-terminus is blocked. {ECO:0000269|PubMed:2166941}.; PTM: Monoubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation. {ECO:0000250|UniProtKB:P49586}.
uniprot
proteins
protein_family
Cytidylyltransferase family
uniprot
proteins
pubmed
12718547
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19783652
uniprot
proteins
pubmed
2166941
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24275660
uniprot
proteins
pubmed
639816
uniprot
proteins
pubmed
8144639
uniprot
proteins
pubmed
8185307
uniprot
proteins
pubmed
8381041
uniprot
proteins
pubmed
8810902
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:639816}. Membrane {ECO:0000269|PubMed:24275660, ECO:0000269|PubMed:639816}; Peripheral membrane protein {ECO:0000269|PubMed:639816}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P49585}; Peripheral membrane protein {ECO:0000269|PubMed:639816}. Nucleus {ECO:0000269|PubMed:8185307}. Note=It can interconvert between an inactive cytosolic form and an active membrane-bound form. {ECO:0000269|PubMed:24275660}.
uniprot
proteins