Q61083
uniprot
Q61083
canonical
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-524 (By similarity). Interacts with PKN2; the interaction activates PKN2 kinase activity in a MAP3K2-independent kinase activity. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKPSSPKKQNDVRVKFEHRGEKRILQVTRPVKLEDLRSKSKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVVNGSTQATNLEPSPSPEDLNNTPLGAERKKRLSVVGPPNRDRSSPPPGYIPDILHQIARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFTDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSFRSPVSFSPTDHSLSTSSGSSVFTPEYDDSRIRRRGSDIDNPTLTVTDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPESPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMELSPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSAEELLRHMFVHYH
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. Plays a role in caveolae kiss-and-run dynamics (By similarity). {ECO:0000250, ECO:0000269|PubMed:12659851}.
uniprot
proteins
mass_dalton
69574
uniprot
proteins
mutagenesis
MUTAGEN 571; /note="F->A: No effect on autophosphorylation. Fails to induce activation of the AP-1 transcription factor, MAPK7 or MAPK8."; /evidence="ECO:0000269|PubMed:12659851"; MUTAGEN 573; /note="I->A: Loss of autophosphorylation. Fails to induce activation of the AP-1 transcription factor, MAPK7 or MAPK8."; /evidence="ECO:0000269|PubMed:12659851"; MUTAGEN 575; /note="T->A: Loss of autophosphorylation and fails to induce activation of the AP-1 transcription factor, MAPK7 or MAPK8; when associated with A-575 and A-576."; /evidence="ECO:0000269|PubMed:12659851"; MUTAGEN 576; /note="Q->A: Loss of autophosphorylation and fails to induce activation of the AP-1 transcription factor, MAPK7 or MAPK8; when associated with A-574 and A-576."; /evidence="ECO:0000269|PubMed:12659851"; MUTAGEN 577; /note="P->A: Loss of autophosphorylation and fails to induce activation of the AP-1 transcription factor, MAPK7 or MAPK8; when associated with A-575 and A-576."; /evidence="ECO:0000269|PubMed:12659851"; MUTAGEN 580; /note="P->A: Loss of autophosphorylation."; /evidence="ECO:0000269|PubMed:12659851"; MUTAGEN 582; /note="L->A: No effect on autophosphorylation and AP-1 transcription factor, MAPK7 or MAPK8 activity. Fails to induce activation and loss of autophosphorylation; when associated with A-582."; /evidence="ECO:0000269|PubMed:12659851"; MUTAGEN 583; /note="P->A: No effect on autophosphorylation and AP-1 transcription factor, MAPK7 or MAPK8 activity. Fails to induce activation and loss of autophosphorylation; when associated with A-581."; /evidence="ECO:0000269|PubMed:12659851"; MUTAGEN 586; /note="V->A: No effect on AP-1 transcription factor activity."; /evidence="ECO:0000269|PubMed:12659851
uniprot
proteins
post_translational_modification
PTM: Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation. {ECO:0000250}.; PTM: Autophosphorylated.
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
10818102
uniprot
proteins
pubmed
12659851
uniprot
proteins
pubmed
12912994
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8621389
uniprot
proteins
sequence_length
619
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus.
uniprot
proteins