Mc3r
entrez
29310
canonical
uniprot
P32244
canonical
ensembl
ENSRNOG00000004451
resolver
ensembl
ENSRNOG00055005008
resolver
ensembl
ENSRNOG00060001753
resolver
ensembl
ENSRNOG00065014091
resolver
ensp
ENSRNOP00000005871
resolver
ensp
ENSRNOP00055006026
resolver
ensp
ENSRNOP00060001778
resolver
ensp
ENSRNOP00065018103
resolver
enst
ENSRNOT00000005871
resolver
enst
ENSRNOT00055007994
resolver
enst
ENSRNOT00060002685
resolver
enst
ENSRNOT00065023252
resolver
genesymbol
Mc3r
resolver
uniprot
Q4KXA4
resolver
uniprot_entry
MC3R_RAT
resolver
uniprot_sec
Q4KXA4
resolver
amino_acid_sequence
MNSSCCPSSSYPTLPNLSQHPAAPSASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVILAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIVVINSDSLTLEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALSLIVAIWVCCGICGVMFIVYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHVQRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNGMNVG
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which contributes to the regulation of energy homeostasis (PubMed:8415620). Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain (By similarity). Binding of the Agouti-related protein/AGPR antagonist precludes alpha-MSH-induced signaling, blocking cAMP production (By similarity). {ECO:0000250|UniProtKB:P33033, ECO:0000250|UniProtKB:P41968, ECO:0000269|PubMed:8415620}.
uniprot
proteins
mass_dalton
35757
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15985309
uniprot
proteins
pubmed
8415620
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 38..63; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 76..100; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 119..140; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 187..210; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 246..268; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 278..301; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins