Gucy1b2
entrez
25206
canonical
uniprot
P22717
canonical
ensembl
ENSRNOG00000009440
resolver
ensp
ENSRNOP00000012948
resolver
ensp
ENSRNOP00000071659
resolver
enst
ENSRNOT00000012948
resolver
genesymbol
Gucy1b2
resolver
uniprot
A0A0G2QC51
resolver
uniprot
Q80WX7
resolver
uniprot
Q91XJ7
resolver
uniprot_entry
A0A0G2QC51_RAT
resolver
uniprot_entry
GCYB2_RAT
resolver
uniprot_entry
Q80WX7_RAT
resolver
uniprot_entry
Q91XJ7_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activity is highly induced by nitric oxide. {ECO:0000269|PubMed:11406623}.
uniprot
proteins
amino_acid_sequence
MYGFINTCLQSLVTEKFGEETWEKLKAPAEVQDVFMTYTVYDDIITIKLIQEACKVLDVSMEAILKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRVEEGADGAMLLHYYSDRHGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVFLVVQKAHRQIRGAKASRPQGSEDSQADQEALQGTLLRMKERYLNIPVCPGEKSHSTAVRASVLFGKGPLRDTFQPVYPERLWVEEEVFCDAFPFHIVFDEALRVKQAGVNIQKYVPGILTQKFALDEYFSIIHPQVTFNISSICKFINSQFVLKTRKEMMPKARKSQPMLKLRGQMIWMESLRCMIFMCSPNVRSLQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVLSNHLAIEKKKTETLLYAMLPEHVANQLKEGRKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTSVHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVTGEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPSKVHLSPTAHRALKNKGFEIVRRGEIEVKGKGKMTTYFLIQNLNATEDEIMGRPSAPADGKEVCTPGNQVRKSPAVPRNTDHQQQVYKGDPADASNEVTLAGSPVAGRNSTDAVNNQPSPDETKTSVVASGPVLSAFCVVL
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Soluble guanylate cyclase that catalyzes the conversion of GTP to cGMP, likely through a heme-containing domain that senses molecular oxygen (PubMed:11406623). Expressed in a subpopulation of sensory neurons in the main olfactory epithelium (type B cells) coexpressing the cation channel TRPC2. Required for Ca(2+) influx in response to low environmental oxygen and hydrogen sulfide, acting upstream of cGMP-dependent protein kinase (PKG) and TRPC2. Mediates conditioned place aversion to hypoxic environments (By similarity). {ECO:0000250|UniProtKB:Q8BXH3, ECO:0000269|PubMed:11406623}.
uniprot
proteins
mass_dalton
83089
uniprot
proteins
mutagenesis
MUTAGEN 596; /note="E->A: Strongly increases guanylate cyclase activity."; /evidence="ECO:0000269|PubMed:11406623"; MUTAGEN 739; /note="C->S: Strongly increases cytosolic guanylate cyclase activity."; /evidence="ECO:0000269|PubMed:11406623
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
11406623
uniprot
proteins
pubmed
1980215
uniprot
proteins
sequence_length
742
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BXH3}. Cytoplasm, cytosol {ECO:0000269|PubMed:11406623}.
uniprot
proteins