IWS1
entrez
55677
canonical
uniprot
Q96ST2
canonical
ensembl
ENSG00000163166
resolver
ensp
ENSP00000295321
resolver
ensp
ENSP00000490836
resolver
ensp
ENSP00000645379
resolver
enst
ENST00000637187
resolver
genesymbol
IWS1
resolver
genesymbol_syn
IWS1L
resolver
hgnc
HGNC:25467
resolver
uniprot
A0A1B0GW95
resolver
uniprot
Q2TB65
resolver
uniprot
Q6P157
resolver
uniprot
Q8N3E8
resolver
uniprot
Q96MI7
resolver
uniprot
Q9NV97
resolver
uniprot
Q9NWH8
resolver
uniprot_entry
A0A1B0GW95_HUMAN
resolver
uniprot_entry
IWS1_HUMAN
resolver
uniprot_sec
Q2TB65
resolver
uniprot_sec
Q6P157
resolver
uniprot_sec
Q8N3E8
resolver
uniprot_sec
Q96MI7
resolver
uniprot_sec
Q9NV97
resolver
uniprot_sec
Q9NWH8
resolver
amino_acid_sequence
MDSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRMNSTGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNVEMESSRFQATSKKGISRLDKQMRKFTDIRKKSRSAHAVKISIEGNKMPL
uniprot
proteins
function
FUNCTION: Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}.
uniprot
proteins
mass_dalton
91955
uniprot
proteins
mutagenesis
MUTAGEN 476; /note="I->A: Loss of interaction with PSIP1; when associated with A-477."; /evidence="ECO:0000269|PubMed:29997176"; MUTAGEN 477; /note="F->A: Loss of interaction with PSIP1; when associated with A-476."; /evidence="ECO:0000269|PubMed:29997176"; MUTAGEN 480; /note="S->D: Phosphomimetic mutant. Moderate increase in interaction with PSIP1."; /evidence="ECO:0000269|PubMed:29997176
uniprot
proteins
post_translational_modification
PTM: Phosphorylation increases its interaction with PSIP1. {ECO:0000269|PubMed:29997176}.
uniprot
proteins
protein_family
IWS1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15302935
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17184735
uniprot
proteins
pubmed
17234882
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19141475
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25689719
uniprot
proteins
pubmed
29997176
uniprot
proteins
sequence_length
819
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649, ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882}.
uniprot
proteins