Kcnc3
entrez
16504
canonical
uniprot
Q63959
canonical
ensembl
ENSMUSG00000062785
resolver
ensp
ENSMUSP00000103539
resolver
ensp
ENSMUSP00000103540
resolver
ensp
ENSMUSP00000146425
resolver
ensp
ENSMUSP00000146535
resolver
ensp
ENSMUSP00000146988
resolver
ensp
ENSMUSP00000339364
resolver
enst
ENSMUST00000107906
resolver
enst
ENSMUST00000107907
resolver
enst
ENSMUST00000207493
resolver
enst
ENSMUST00000208651
resolver
genesymbol
Kcnc3
resolver
uniprot
A0A140LHI4
resolver
uniprot
A0A140LIW8
resolver
uniprot
D3YZV2
resolver
uniprot
E9Q5E5
resolver
uniprot
E9QKI2
resolver
uniprot
Q62088
resolver
uniprot_entry
A0A140LHI4_MOUSE
resolver
uniprot_entry
A0A140LIW8_MOUSE
resolver
uniprot_entry
E9QKI2_MOUSE
resolver
uniprot_entry
KCNC3_MOUSE
resolver
uniprot_sec
D3YZV2
resolver
uniprot_sec
E9Q5E5
resolver
uniprot_sec
Q62088
resolver
amino_acid_sequence
MLSSVCVWSFRGRQGTGKQQPQPVPTPQPPESSPPPLPPPQQQQCSQPGTAASPAGAPLSCGPGGRRAEPCPGLPAVAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGTDEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDSSANANANAGGAHDAGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPAGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRVTFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVNVAGAYPPGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIETNRADPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYSRDRACFLVTDYAPSPDGSIRKGYEKSRSLSSIVGLSGVSLRLAPLATPPGSPRATRRAPPTLPSIL
uniprot
proteins
function
FUNCTION: Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:15217387, PubMed:18539595, PubMed:24218544, PubMed:26997484). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells (PubMed:15217387, PubMed:18448641, PubMed:24218544). Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (PubMed:24218544). Required for normal motor function (PubMed:16923152, PubMed:18448641). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484). {ECO:0000269|PubMed:15217387, ECO:0000269|PubMed:16923152, ECO:0000269|PubMed:18448641, ECO:0000269|PubMed:18539595, ECO:0000269|PubMed:24218544, ECO:0000269|PubMed:26997484}.
uniprot
proteins
mass_dalton
81946
uniprot
proteins
mutagenesis
MUTAGEN 424; /note="R->H: Loss of channel activity. Functions as dominant negative mutation that impairs function of wild-type channel subunits. Causes impaired Purkinje cell dendrite growth and premature death of cerebellar Purkinje cells."; /evidence="ECO:0000269|PubMed:24218544"; MUTAGEN 593; /note="G->R: No effect on voltage-dependent channel opening or current amplitude, but decreased rate of inactivation during prolonged depolarization."; /evidence="ECO:0000269|PubMed:26997484
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q14003}.
uniprot
proteins
protein_family
C (Shaw) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv3.3/KCNC3 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
11517255
uniprot
proteins
pubmed
15217387
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
16923152
uniprot
proteins
pubmed
1740329
uniprot
proteins
pubmed
18448641
uniprot
proteins
pubmed
18539595
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24218544
uniprot
proteins
pubmed
26997484
uniprot
proteins
pubmed
8301351
uniprot
proteins
sequence_length
769
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15217387, ECO:0000269|PubMed:18448641, ECO:0000269|PubMed:18539595, ECO:0000269|PubMed:24218544, ECO:0000269|PubMed:26997484}; Multi-pass membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000269|PubMed:26997484}; Multi-pass membrane protein {ECO:0000255}. Perikaryon {ECO:0000269|PubMed:15217387}. Cell projection, axon {ECO:0000269|PubMed:15217387}. Cell projection, dendrite {ECO:0000269|PubMed:15217387, ECO:0000269|PubMed:18448641}. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:Q01956}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q14003}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q14003}. Note=Detected on Purkinje cell dendritic spines, positioned perisynaptically but also in extrasynaptic positions along the spine membranes (By similarity). Detected at presynaptic calices of Held (PubMed:26997484). Colocalizes with the cortical actin cytoskeleton and the Arp2/3 complex (By similarity). {ECO:0000250|UniProtKB:Q01956, ECO:0000250|UniProtKB:Q14003}.
uniprot
proteins
transmembrane_region
TRANSMEM 292..310; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 352..371; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 381..399; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 413..435; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 449..470; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 519..540; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins