Cacybp
entrez
12301
canonical
uniprot
Q9CXW3
canonical
ensembl
ENSMUSG00000014226
resolver
ensp
ENSMUSP00000014370
resolver
enst
ENSMUST00000014370
resolver
genesymbol
Cacybp
resolver
genesymbol_syn
Sip
resolver
uniprot
O70140
resolver
uniprot_entry
CYBP_MOUSE
resolver
uniprot_sec
O70140
resolver
amino_acid_sequence
MASVLEELQKDLEEVKVLLEKSTRKRLRDTLTSEKSKIETELKNKMQQKSQKKPELDNEKPAAVVAPLTTGYTVKISNYGWDQSDKFVKIYITLTGVHQVPTENVQVHFTERSFDLLVKNLNGKNYSMIVNNLLKPISVESSSKKVKTDTVIILCRKKAENTRWDYLTQVEKECKEKEKPSYDTEADPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAREDTEF
uniprot
proteins
function
FUNCTION: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
26510
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations. {ECO:0000269|PubMed:11927578}.
uniprot
proteins
pubmed
10884380
uniprot
proteins
pubmed
11927578
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15996101
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18803400
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9572262
uniprot
proteins
sequence_length
229
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11927578}. Cytoplasm {ECO:0000269|PubMed:11927578}. Note=Cytoplasmic in unstimulated cultured neurons. Upon increase of calcium, it localizes to a ring around the nucleus. In neuroblastoma cells, after a Retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear and perinuclear fractions may be phosphorylated.
uniprot
proteins