H1-6
entrez
24438
canonical
uniprot
P06349
canonical
ensembl
ENSRNOG00055005501
resolver
ensembl
ENSRNOG00060015098
resolver
ensembl
ENSRNOG00065022918
resolver
ensp
ENSRNOP00055006725
resolver
ensp
ENSRNOP00060020692
resolver
ensp
ENSRNOP00065031793
resolver
enst
ENSRNOT00055008835
resolver
enst
ENSRNOT00060025872
resolver
enst
ENSRNOT00065039139
resolver
genesymbol
H1-6
resolver
genesymbol_syn
H1f6
resolver
genesymbol_syn
H1ft
resolver
genesymbol_syn
H1t
resolver
uniprot_entry
H1T_RAT
resolver
amino_acid_sequence
MSETAPAASSTLVPAPVEKPATKRRGKKPGMATARKPRGFSVSKLIPEALSMSQERAGMSLAALKKALAAAGYDVEKNNSRIKLALKRLVNKGVLVQTKGTGASGSFKLSKKAASGNDKGKGKKSASAKAKKLGLSRASRSPKSSKTKVVKKPKATPTKGSGSRRKTKGAKGLQQRKSPAKARATNSNSGKSKMVMQKTDLRKAAGRK
uniprot
proteins
function
FUNCTION: Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration. {ECO:0000250|UniProtKB:P22492}.
uniprot
proteins
mass_dalton
21726
uniprot
proteins
mutagenesis
MUTAGEN 54; /note="Q->K: Increased affinity for DNA."; /evidence="ECO:0000269|PubMed:17052712
uniprot
proteins
post_translational_modification
PTM: Deamidation of Asn-78 and Asn-79 by CTPS1 in response to DNA damage promotes subsequent acetylation of histone H1 at Lys-77 (H1K75ac). {ECO:0000250|UniProtKB:P10412}.; PTM: Acetylated at Lys-77 (H1K75ac) by EP300 following deamidation of Asn-78 and Asn-79 by CTPS1 in response to DNA damage, thereby increasing chromatin accessibility to facilitate the recruitment of DNA repair proteins. {ECO:0000250|UniProtKB:P10412}.; PTM: Phosphorylated in early spermatids. {ECO:0000269|PubMed:19043117}.; PTM: Citrullination at Arg-56 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. {ECO:0000250|UniProtKB:P43275}.
uniprot
proteins
protein_family
Histone H1/H5 family
uniprot
proteins
pubmed
17052712
uniprot
proteins
pubmed
1706721
uniprot
proteins
pubmed
19043117
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2423516
uniprot
proteins
pubmed
3947637
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
uniprot
proteins