Mlxipl
entrez
171078
canonical
uniprot
Q8VIP2
canonical
ensembl
ENSRNOG00000046171
resolver
ensp
ENSRNOP00000090385
resolver
ensp
ENSRNOP00000093059
resolver
enst
ENSRNOT00000074230
resolver
genesymbol
Mlxipl
resolver
genesymbol_syn
AABR07035839.1
resolver
genesymbol_syn
Wbscr14
resolver
uniprot
A0A8I6ADP9
resolver
uniprot_entry
A0A8I6ADP9_RAT
resolver
uniprot_entry
MLXPL_RAT
resolver
amino_acid_sequence
MARALADLSVNLQVPRVVPSPDSDSDTDLEDPSPRRSAGGLHRSQVIHSGHFMVSSPHSDSLTRRRDQEGPVGLADFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVQRRKSPVCGFVTPLQGSEADEHRKPEAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKSSREGDFLAPKQVEGGWPPPERWCEQLFSSVVPVLLGGSEEEPGGRQLLDLDCFLSDISDTLFTMTQPSPSSLQLPSEDAYVGNADMIQPDLTPLQPSLDDFMEISDFFTNYRPPQTPTSSNFPEPPSFGPMADSLFSGGILGPEMPSPASASSSSGMTPLSGNTRLQARNSCSGPLDPSTFPSSEFLLPEDPKTKMPPAPVPTPLLPYPGPVKVHGLEPCTPSPFPTMAPPPALLSEEPLFSARFPFTTVPPAPGVSTLPAPTTFVPTPQPGPGPGPVPFPVDHLPHGYLEPVFGPHFTVPQGVQPRCKPCSPPPGGRKASPPTLTSATASPTATATARDNNPCLTQLLRAAKPEQVLEPSTVPSTLLRPPESPDAVPEIPRVRAFYPPIPAPTPPRPPPGPATLAPPRSLVVPKAERLSPPASSGSERRPSGDLNSIQPPGALSVHLSPPQTVLSRGRVDNNKMENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEIEELNAAINLCQQQLPATGVPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFESFNGMVSTASLHSLRQTSLAWLDQYCSLPALRPTVLNSLRQLSTSTSILTDPSLVPEQATRAVTEGPLGRPL
uniprot
proteins
function
FUNCTION: Glucose-responsive transcription activator that regulates fatty acid synthesis and glycolysis (PubMed:11724780). Key determinant of systemic insulin sensitivity and glucose homeostasis. Important for the expression of fatty acid synthetic enzymes, including PC/Pcx, APOC4/Acl, ACACA/Acc1 and FASN/Fas (By similarity). Important for glucose-induced expression of L-type pyruvate kinase/PKLR (PubMed:11724780). Binds to the canonical and non-canonical E box DNA sequences 5'-CACGTG-3' and 5'-CACGCG-3' (By similarity). May also act as a transcriptional repressor (By similarity). {ECO:0000250|UniProtKB:Q99MZ3, ECO:0000269|PubMed:11724780}.
uniprot
proteins
mass_dalton
94921
uniprot
proteins
mutagenesis
MUTAGEN 568; /note="S->A: Strong DNA binding and high transcriptional activity, even in the presence of palmitate, compared to wild-type."; /evidence="ECO:0000269|PubMed:11724780"; MUTAGEN 568; /note="S->D: Decreased DNA-binding and strongly decreased transcriptional activity."; /evidence="ECO:0000269|PubMed:11724780
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-568 by AMPK inactivates the DNA-binding activity. {ECO:0000269|PubMed:11724780}.
uniprot
proteins
pubmed
11724780
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
865
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:11724780}. Nucleus {ECO:0000305|PubMed:11724780}. Note=Localizes mainly in the cytoplasm of hepatocytes under low glucose and migrates into the nucleus under high glucose. {ECO:0000305|PubMed:11724780}.
uniprot
proteins