Kmt5b
entrez
361688
canonical
uniprot
P0C2N5
canonical
ensembl
ENSRNOG00000016790
resolver
ensembl
ENSRNOG00055021177
resolver
ensembl
ENSRNOG00060032548
resolver
ensembl
ENSRNOG00065031695
resolver
ensp
ENSRNOP00000022486
resolver
ensp
ENSRNOP00000080478
resolver
ensp
ENSRNOP00055029402
resolver
ensp
ENSRNOP00060046602
resolver
ensp
ENSRNOP00065044908
resolver
enst
ENSRNOT00000022486
resolver
enst
ENSRNOT00000102948
resolver
enst
ENSRNOT00055036191
resolver
enst
ENSRNOT00060056400
resolver
enst
ENSRNOT00065054600
resolver
genesymbol
Kmt5b
resolver
genesymbol_syn
Suv420h1
resolver
uniprot
A0A8I6G6N5
resolver
uniprot_entry
A0A8I6G6N5_RAT
resolver
uniprot_entry
KMT5B_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine (A-196). A-196 is competitive with the histone peptide substrate H4K20me1 but non competitive with S-adenosyl-L-methionine. {ECO:0000250|UniProtKB:Q4FZB7}.
uniprot
proteins
amino_acid_sequence
MKWLGDSKNMVVNGRRNGSKLSNDHQQNQSKLQHAGKDALKTGRNAVERRPNRCHGNSGFEGQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTSAFPSRSSRHISKADSFSHNNPMRFRPIKGRQEELKEVIERFKKDEHLEKAFKCLTSGEWARHYFLNKNKMQEKLFKEHVFIYLRMFATDSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSRVGLPAPAPVINSKYGLRETDKRLNRLKKLGDSSKSSDSQSVSSNTDADTTQEKDNATSNRKSSVGVKKNSKSRALTRQSMPRVPAASNSTSPKLVHMNNSRVPKKLRKPAKPLLSKIKLRNHCKRLDQKSTSRKLEMGNLVLKEPKVVLYKNLPIKKEREAEGPVHAAVGSGCLTRHAAREHRQNPGRGAHSQGDSLPCTYTTRRSLRTRTGLKETTDIKLAPSPLDGYKNGILEPYPDSGQQPTPEVLEELAPETALREEASQECPKSDSCPSRKKFRQGKPVKHLAKTEDCSPEHSFPGKDGLPDLPGPHPDQGEPSGTVRVPVSYTDSAPSPVGCSIVTPDSFTTKDSFRTAQSKKKRRVTRYDAQLILENSSGIPKLTLRRRHDSSSKTNDHESDSVNSSKISIKLSKDHESDSNLYVAKLSNGVSSGPGSSSTKLKIQLKRDEESRGPCAEGLHENGVCCSDPLSLLESQMEVDDYSQYEEDSTDDSSSSEGEEEEEDCEDDFDDDFIPLPPAKRLRLIVGKDSIDIDISSRRREDQSLRLNA
uniprot
proteins
ec_number
2.1.1.361
uniprot
proteins
ec_number
2.1.1.362
uniprot
proteins
function
FUNCTION: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). {ECO:0000250|UniProtKB:Q3U8K7, ECO:0000250|UniProtKB:Q4FZB7}.
uniprot
proteins
mass_dalton
98668
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
protein_family
Suvar4-20 subfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
883
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome {ECO:0000250}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.
uniprot
proteins