Pwwp2b
entrez
101631
canonical
uniprot
E9Q9M8
canonical
ensembl
ENSMUSG00000060260
resolver
ensp
ENSMUSP00000091529
resolver
ensp
ENSMUSP00000130888
resolver
enst
ENSMUST00000093993
resolver
enst
ENSMUST00000172136
resolver
genesymbol
Pwwp2b
resolver
genesymbol_syn
Pwwp2
resolver
uniprot
F6ZSX9
resolver
uniprot
Q14AS8
resolver
uniprot
Q3TYY8
resolver
uniprot_entry
F6ZSX9_MOUSE
resolver
uniprot_entry
PWP2B_MOUSE
resolver
uniprot_entry
Q14AS8_MOUSE
resolver
uniprot_entry
Q3TYY8_MOUSE
resolver
amino_acid_sequence
MEPRAGCRLPVRVEQVVNGALVVTVSCGERSFAGILLDCTKKSGLFGLSPSTLLPLADNSSAVSCHGQAPEEGTGEVMQLETGPLHPHHKDPEKDQPPKTAVSEPPPPLIPPVPAGNLPPFPPYFEGAPFPHPLWLRNTYQQWVPQPPPRTIKRTRRRLSRNRDPGRLILSTIRLRPRQVLCEKCKSTVSPQEASPSPLNTPKPRRRLGSGPDSEHRKPEEPEDSAVIATAAPRRSKREKREEDRVAGERVPRSPVIKISYSTPQGKGEVVKIPSRVHGSVEPFCPQQSLQNGSQDSEVSRDVEPRGGGDRPPSGSSASIPKLKLTRPVPPISDLPPPKIRLKPHRLGDGEHEPLYRAELVEELNGCPRGPLVSSPALFADGSSHGLEDLSSGSSGEDDDLKRFPQGKHGRDGLAFLVDCPGRRTDCTSESVCSTDSLDELKSSGSEVTSPDTGDLSSGDSASVPSSSADTRQTVPPLTVRLHTQSVSRCVTEDGRTVAVGDIVWGKIHGFPWWPARVLDISLGQKEDGEPSWQEAKVSWFGSPTTSFLSISKLSPFSEFFKLRFNRKKKGMYRKAITEAANATQHVAPEIRELLTQFEM
uniprot
proteins
function
FUNCTION: Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (By similarity). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (PubMed:30228260). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (PubMed:34180153). {ECO:0000250|UniProtKB:Q6NUJ5, ECO:0000269|PubMed:30228260, ECO:0000269|PubMed:34180153}.
uniprot
proteins
mass_dalton
65434
uniprot
proteins
post_translational_modification
PTM: Deubiquitinated by BRCC3; leading to its stabilization. {ECO:0000269|PubMed:34180153}.
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
30228260
uniprot
proteins
pubmed
34180153
uniprot
proteins
sequence_length
600
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34180153}.
uniprot
proteins