SRD5A1
entrez
6715
canonical
uniprot
P18405
canonical
ensembl
ENSG00000145545
resolver
ensp
ENSP00000274192
resolver
enst
ENST00000274192
resolver
genesymbol
SRD5A1
resolver
hgnc
HGNC:11284
resolver
uniprot
B2R7Q1
resolver
uniprot
B7Z4D8
resolver
uniprot
Q9UHY4
resolver
uniprot
Q9UP36
resolver
uniprot
Q9UP37
resolver
uniprot_entry
B7Z4D8_HUMAN
resolver
uniprot_entry
S5A1_HUMAN
resolver
uniprot_sec
B2R7Q1
resolver
uniprot_sec
Q9UHY4
resolver
uniprot_sec
Q9UP36
resolver
uniprot_sec
Q9UP37
resolver
amino_acid_sequence
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
uniprot
proteins
ec_number
1.3.1.22
uniprot
proteins
function
FUNCTION: Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed:2339109, PubMed:23685396). Converts testosterone into 5-alpha-dihydrotestosterone (DHT), a more potent androgen as it is the preferred ligand for androgen receptor (AR) transactivation, making this reaction a key step in male sexual differentiation during development (PubMed:2339109, PubMed:23685396). Besides testosterone, it can also act on other steroids, including progesterone, androstenedione, and corticoids, producing metabolites with diverse roles (PubMed:2339109). Hence, it plays a central role in sexual differentiation and androgen physiology (PubMed:2339109). {ECO:0000269|PubMed:2339109, ECO:0000269|PubMed:23685396}.
uniprot
proteins
mass_dalton
29459
uniprot
proteins
protein_family
Steroid 5-alpha reductase family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
11678334
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1686016
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
2339109
uniprot
proteins
pubmed
23685396
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 86..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 111..131; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 151..171; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 209..229; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins