ARHGDIA
entrez
396
canonical
uniprot
P52565
canonical
ensembl
ENSG00000141522
resolver
ensp
ENSP00000269321
resolver
ensp
ENSP00000383556
resolver
ensp
ENSP00000441348
resolver
ensp
ENSP00000462960
resolver
ensp
ENSP00000463939
resolver
enst
ENST00000584461
resolver
genesymbol
ARHGDIA
resolver
genesymbol
HEL-S-47e
resolver
genesymbol_syn
ARHGDIA
resolver
genesymbol_syn
GDIA1
resolver
hgnc
HGNC:678
resolver
uniprot
A8MXW0
resolver
uniprot
B2R5X1
resolver
uniprot
B4DDD3
resolver
uniprot
B4DUV9
resolver
uniprot
J3QQX2
resolver
uniprot
Q6IBM5
resolver
uniprot
V9HWE8
resolver
uniprot_entry
GDIR1_HUMAN
resolver
uniprot_entry
J3QQX2_HUMAN
resolver
uniprot_entry
V9HWE8_HUMAN
resolver
uniprot_sec
A8MXW0
resolver
uniprot_sec
B2R5X1
resolver
uniprot_sec
B4DDD3
resolver
uniprot_sec
B4DUV9
resolver
uniprot_sec
Q6IBM5
resolver
amino_acid_sequence
MAEQEPTAEQLAQIAAENEEDEHSVNYKPPAQKSIQEIQELDKDDESLRKYKEALLGRVAVSADPNVPNVVVTGLTLVCSSAPGPLELDLTGDLESFKKQSFVLKEGVEYRIKISFRVNREIVSGMKYIQHTYRKGVKIDKTDYMVGSYGPRAEEYEFLTPVEEAPKGMLARGSYSIKSRFTDDDKTDHLSWEWNLTIKKDWKD
uniprot
proteins
disease_involvement
DISEASE: Nephrotic syndrome 8 (NPHS8) [MIM:615244]: A form of nephrotic syndrome, a renal disease clinically characterized by progressive renal failure, severe proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show diffuse mesangial sclerosis, with small glomeruli, hypercellularity, increased extracellular matrix, and contracted/collapsed glomerular tufts surrounded by immature or abnormal podocytes. {ECO:0000269|PubMed:23434736}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}.
uniprot
proteins
mass_dalton
23207
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="D->A: Loss of RHOA interaction; when associated with A-185."; /evidence="ECO:0000269|PubMed:20400958"; MUTAGEN 99; /note="K->A: Loss of interaction with NGFR."; /evidence="ECO:0000269|PubMed:26646181"; MUTAGEN 185; /note="D->A: Loss of RHOA interaction; when associated with A-45."; /evidence="ECO:0000269|PubMed:20400958"; MUTAGEN 199; /note="K->A: Loss of interaction with NGFR."; /evidence="ECO:0000269|PubMed:26646181
uniprot
proteins
protein_family
Rho GDI family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16916647
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20400958
uniprot
proteins
pubmed
20628200
uniprot
proteins
pubmed
21122136
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23434736
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
25961457
uniprot
proteins
pubmed
26646181
uniprot
proteins
pubmed
8262133
uniprot
proteins
pubmed
8504089
uniprot
proteins
pubmed
9195882
uniprot
proteins
sequence_length
204
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23434736}.
uniprot
proteins