Grhl2
entrez
252973
canonical
uniprot
Q8K5C0
canonical
ensembl
ENSMUSG00000022286
resolver
ensp
ENSMUSP00000022895
resolver
ensp
ENSMUSP00000125410
resolver
enst
ENSMUST00000022895
resolver
enst
ENSMUST00000161405
resolver
genesymbol
Grhl2
resolver
genesymbol_syn
Bom
resolver
genesymbol_syn
Tcfcp2l3
resolver
uniprot
F7C252
resolver
uniprot
Q80UZ5
resolver
uniprot
Q9DCN4
resolver
uniprot_entry
F7C252_MOUSE
resolver
uniprot_entry
GRHL2_MOUSE
resolver
uniprot_entry
Q9DCN4_MOUSE
resolver
uniprot_sec
Q80UZ5
resolver
amino_acid_sequence
MSQESDNNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRDKRLLSVSKASDSQEDQDKRNCLGTSEAQINLSGGENRVQVLKTVPVNLCLSQDHMENSKREQYSVSITESSAVIPVSGITVVKAEDFTPVFMAPPVHYPRADSEEQRVVIFEQTQYDLPSIASHSSYLKDDQRSTPDSTYSESFKDGASEKFRSTSVGADEYTYDQTGSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERKQNRKKGKGQASQAQCNNSSDGKMAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGSSVLVKRMFRPMEEEFGPTPSKQIKEENVKRVLLYVRKENDDVFDALMLKSPTVKGLMEALSEKYGLPVEKITKLYKKSKKGILVNMDDNIIEHYSNEDTFILNMESMVEGFKITLMEI
uniprot
proteins
function
FUNCTION: Transcription factor playing an important role in primary neurulation and in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:22696678). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (PubMed:20654612). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (PubMed:22696678). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia (PubMed:20978075). Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events such as eyelid fusion and epidermal wound repair (PubMed:21081122). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (PubMed:22955271). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity. In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (By similarity). {ECO:0000250|UniProtKB:Q6ISB3, ECO:0000269|PubMed:20654612, ECO:0000269|PubMed:20978075, ECO:0000269|PubMed:21081122, ECO:0000269|PubMed:22696678, ECO:0000269|PubMed:22955271}.
uniprot
proteins
mass_dalton
71195
uniprot
proteins
protein_family
Grainyhead subfamily
uniprot
proteins
protein_family
Grh/CP2 family
uniprot
proteins
pubmed
12175488
uniprot
proteins
pubmed
12393799
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20654612
uniprot
proteins
pubmed
20978075
uniprot
proteins
pubmed
21081122
uniprot
proteins
pubmed
22696678
uniprot
proteins
pubmed
22955271
uniprot
proteins
sequence_length
625
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20978075, ECO:0000269|PubMed:22696678}. Membrane {ECO:0000250|UniProtKB:Q6ISB3}. Note=detected at cell-cell contact areas. {ECO:0000250|UniProtKB:Q6ISB3}.
uniprot
proteins