Otc
entrez
25611
canonical
uniprot
P00481
canonical
ensembl
ENSRNOG00000003370
resolver
ensembl
ENSRNOG00055029219
resolver
ensembl
ENSRNOG00060026685
resolver
ensembl
ENSRNOG00065011638
resolver
ensp
ENSRNOP00000004686
resolver
ensp
ENSRNOP00055041733
resolver
ensp
ENSRNOP00060038452
resolver
ensp
ENSRNOP00065014456
resolver
enst
ENSRNOT00000004686
resolver
enst
ENSRNOT00055050656
resolver
enst
ENSRNOT00060046282
resolver
enst
ENSRNOT00065018925
resolver
genesymbol
Otc
resolver
uniprot
Q63407
resolver
uniprot_entry
OTC_RAT
resolver
uniprot_sec
Q63407
resolver
activity_regulation
ACTIVITY REGULATION: Negatively regulated by lysine acetylation. {ECO:0000250|UniProtKB:P00480}.
uniprot
proteins
amino_acid_sequence
MLSNLRILLNKAALRKAHTSMVRNFRYGKPVQSQVQLKGRDLLTLKNFTGEEIQYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFALLGGHPSFLTTQDIHLGVNESLTDTARVLSSMTDAVLARVYKQSDLDILAKEATIPIVNGLSDLYHPIQILADYLTLQEHYGSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQAATPKGYEPDPNIVKLAEQYAKENGTRLSMTNDPLEAARGGNVLITDTWISMGQEDEKKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWTIMAVMVSLLTDYSPVLQKPKF
uniprot
proteins
ec_number
2.1.3.3
uniprot
proteins
function
FUNCTION: Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline (PubMed:2290837). The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion (PubMed:2290837). {ECO:0000269|PubMed:2290837}.
uniprot
proteins
mass_dalton
39886
uniprot
proteins
mutagenesis
MUTAGEN 92; /note="R->L: Strong decrease in ornithine carbamoyltransferase activity."; /evidence="ECO:0000269|PubMed:2290837"; MUTAGEN 303; /note="C->S: Increases KM for ornithine 5-fold and decreases kcat 20-fold."; /evidence="ECO:0000269|PubMed:2290837
uniprot
proteins
pathway_participation
PATHWAY: Nitrogen metabolism; urea cycle; L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1. {ECO:0000305|PubMed:2290837}.
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-88 negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. {ECO:0000250|UniProtKB:P00480}.
uniprot
proteins
protein_family
Aspartate/ornithine carbamoyltransferase superfamily
uniprot
proteins
protein_family
OTCase family
uniprot
proteins
pubmed
2290837
uniprot
proteins
pubmed
3390141
uniprot
proteins
pubmed
3476935
uniprot
proteins
pubmed
3838931
uniprot
proteins
pubmed
3839075
uniprot
proteins
pubmed
6095294
uniprot
proteins
pubmed
6548714
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P00480}.
uniprot
proteins