Cxcr2
entrez
29385
canonical
uniprot
P35407
canonical
ensembl
ENSRNOG00000063618
resolver
ensembl
ENSRNOG00055009510
resolver
ensembl
ENSRNOG00060007107
resolver
ensembl
ENSRNOG00065008665
resolver
ensp
ENSRNOP00000093296
resolver
ensp
ENSRNOP00000110815
resolver
ensp
ENSRNOP00055012901
resolver
ensp
ENSRNOP00060008782
resolver
ensp
ENSRNOP00065010201
resolver
enst
ENSRNOT00000101059
resolver
enst
ENSRNOT00000144913
resolver
enst
ENSRNOT00055016067
resolver
enst
ENSRNOT00060011670
resolver
enst
ENSRNOT00065013752
resolver
genesymbol
Cxcr2
resolver
genesymbol_syn
Il8rb
resolver
uniprot_entry
CXCR2_RAT
resolver
amino_acid_sequence
MGEIRVDNFSLEDFFSGDIDSYNYSSDPPFTLSDAAPCPSANLDINRYAVVVIYVLVTLLSLVGNSLVMLVILYNRSTCSVTDVYLLNLAIADLFFALTLPVWAASKVNGWIFGSFLCKVFSFLQEITFYSSVLLLACISMDRYLAIVHATSTLIQKRHLVKFVCITMWFLSLVLSLPIFILRTTVKANPSTVVCYENIGNNTSKWRVVLRILPQTYGFLLPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLVFLLCWLPYNIVLFTDTLMRTKLIKETCERQNEINKALEATEILGFLHSCLNPIIYAFIGQKFRHGLLKIMANYGLVSKEFLAKEGRPSFVGSSSANTSTTL
uniprot
proteins
function
FUNCTION: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. Signals intravascular neutrophil chemotaxis to the injury site (By similarity). {ECO:0000250|UniProtKB:P25025, ECO:0000250|UniProtKB:P35343}.
uniprot
proteins
mass_dalton
40532
uniprot
proteins
post_translational_modification
PTM: Phosphorylated upon ligand binding; which is required for desensitization. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
8955112
uniprot
proteins
pubmed
9218548
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 48..74; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 120..141; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 163..182; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 208..230; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 251..272; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 297..314; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins