Tmem196
entrez
500750
canonical
uniprot
Q5EB63
canonical
ensembl
ENSRNOG00000037435
resolver
ensp
ENSRNOP00000053487
resolver
ensp
ENSRNOP00000107128
resolver
enst
ENSRNOT00000056649
resolver
enst
ENSRNOT00000161658
resolver
genesymbol
Tmem196
resolver
uniprot
A0A8L2QSV5
resolver
uniprot
A0ABK0LR24
resolver
uniprot_entry
A0A8L2QSV5_RAT
resolver
uniprot_entry
A0ABK0LR24_RAT
resolver
uniprot_entry
TM196_RAT
resolver
amino_acid_sequence
MCTSGQIIGSLLVLSVLEIGLGVSSVAVGAVSFSLALREHTPQLGDSSPFLLCGICGILCAKKKSGLVMILFSACCICGLIGGILNFQFLRAVTKKTSSLYPLHLASMSLACIGIGGCTVSSWLTCRLASYEQRRMFSEREHSLHHSHEMAEKEVTDNMSNGAPQLIFNGRVQSMF
uniprot
proteins
function
FUNCTION: Acts as a tumor suppressor in lung cancer. Inhibits tumor cell growth by inhibiting cell proliferation and migration and promoting cell apoptosis. Inhibits metastasis of lung cancer by suppressing beta-catenin expression in the Wnt/beta-catenin signaling pathway. {ECO:0000250|UniProtKB:D3YWQ9, ECO:0000250|UniProtKB:Q5HYL7}.
uniprot
proteins
mass_dalton
18846
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
176
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5HYL7}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 41..61; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 67..87; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins