APLP2
entrez
334
canonical
uniprot
Q06481
canonical
ensembl
ENSG00000084234
resolver
ensp
ENSP00000263574
resolver
ensp
ENSP00000263575
resolver
ensp
ENSP00000278756
resolver
ensp
ENSP00000345444
resolver
ensp
ENSP00000435914
resolver
ensp
ENSP00000551730
resolver
ensp
ENSP00000551731
resolver
ensp
ENSP00000551732
resolver
ensp
ENSP00000551745
resolver
ensp
ENSP00000551747
resolver
genesymbol
APLP2
resolver
genesymbol_syn
APPL2
resolver
hgnc
HGNC:598
resolver
uniprot
A0A140VJE9
resolver
uniprot
B3KXX9
resolver
uniprot
B4E3I5
resolver
uniprot
H7BXI4
resolver
uniprot
Q13861
resolver
uniprot
Q14594
resolver
uniprot
Q14662
resolver
uniprot
Q71U10
resolver
uniprot
Q7M4L3
resolver
uniprot
Q9BT36
resolver
uniprot_entry
A0A140VJE9_HUMAN
resolver
uniprot_entry
APLP2_HUMAN
resolver
uniprot_entry
B4E3I5_HUMAN
resolver
uniprot_sec
B3KXX9
resolver
uniprot_sec
H7BXI4
resolver
uniprot_sec
Q13861
resolver
uniprot_sec
Q14594
resolver
uniprot_sec
Q14662
resolver
uniprot_sec
Q71U10
resolver
uniprot_sec
Q7M4L3
resolver
uniprot_sec
Q9BT36
resolver
amino_acid_sequence
MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
uniprot
proteins
function
FUNCTION: May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). {ECO:0000250, ECO:0000269|PubMed:8307156}.
uniprot
proteins
mass_dalton
86956
uniprot
proteins
post_translational_modification
PTM: The BPTI/Kunitz inhibitor domain is O-glycosylated. {ECO:0000269|PubMed:8307156}.
uniprot
proteins
protein_family
APP family
uniprot
proteins
pubmed
10081969
uniprot
proteins
pubmed
11101689
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
32337544
uniprot
proteins
pubmed
7651835
uniprot
proteins
pubmed
7702756
uniprot
proteins
pubmed
8220435
uniprot
proteins
pubmed
8307156
uniprot
proteins
pubmed
8485127
uniprot
proteins
pubmed
8855266
uniprot
proteins
sequence_length
763
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 693..716; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins