Masp2
entrez
17175
canonical
uniprot
Q91WP0
canonical
ensembl
ENSMUSG00000028979
resolver
ensp
ENSMUSP00000049729
resolver
ensp
ENSMUSP00000101326
resolver
genesymbol
Masp2
resolver
uniprot
B1ARY2
resolver
uniprot
B1ARY3
resolver
uniprot
Q9QXA4
resolver
uniprot
Q9QXD2
resolver
uniprot
Q9QXD5
resolver
uniprot
Q9Z338
resolver
uniprot_entry
MASP2_MOUSE
resolver
uniprot_sec
B1ARY2
resolver
uniprot_sec
B1ARY3
resolver
uniprot_sec
Q9QXA4
resolver
uniprot_sec
Q9QXD2
resolver
uniprot_sec
Q9QXD5
resolver
uniprot_sec
Q9Z338
resolver
amino_acid_sequence
MRLLIFLGLLWSLVATLLGSKWPEPVFGRLVSPGFPEKYADHQDRSWTLTAPPGYRLRLYFTHFDLELSYRCEYDFVKLSSGTKVLATLCGQESTDTEQAPGNDTFYSLGPSLKVTFHSDYSNEKPFTGFEAFYAAEDVDECRVSLGDSVPCDHYCHNYLGGYYCSCRAGYVLHQNKHTCSALCSGQVFTGRSGYLSSPEYPQPYPKLSSCTYSIRLEDGFSVILDFVESFDVETHPEAQCPYDSLKIQTDKGEHGPFCGKTLPPRIETDSHKVTITFATDESGNHTGWKIHYTSTARPCPDPTAPPNGSISPVQAIYVLKDRFSVFCKTGFELLQGSVPLKSFTAVCQKDGSWDRPMPECSIIDCGPPDDLPNGHVDYITGPEVTTYKAVIQYSCEETFYTMSSNGKYVCEADGFWTSSKGEKLPPVCEPVCGLSTHTIGGRIVGGQPAKPGDFPWQVLLLGQTTAAAGALIHDNWVLTAAHAVYEKRMAASSLNIRMGILKRLSPHYTQAWPEEIFIHEGYTHGAGFDNDIALIKLKNKVTINGSIMPVCLPRKEAASLMRTDFTGTVAGWGLTQKGLLARNLMFVDIPIADHQKCTAVYEKLYPGVRVSANMLCAGLETGGKDSCRGDSGGALVFLDNETQRWFVGGIVSWGSINCGAADQYGVYTKVINYIPWIENIISNF
uniprot
proteins
ec_number
3.4.21.104
uniprot
proteins
function
FUNCTION: Precursor of a serum protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The lectin complement system is activated following association of lectins, such as MBL2, FCN1, FCN2 or FCN3, to carbohydrates on the pathogen surface. MASP2 is cleaved and activated by MASP1 in response to lectin-binding to pathogen carbohydrates. Can activate prothrombin to thrombin. {ECO:0000250|UniProtKB:O00187}.; FUNCTION: [Mannan-binding lectin serine protease 2 B chain]: Serine protease component of the lectin complement pathway, which catalyzes cleavage and activation of C2 and C4, the next components of the complement pathway. {ECO:0000250|UniProtKB:O00187}.
uniprot
proteins
mass_dalton
75517
uniprot
proteins
post_translational_modification
PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. {ECO:0000250|UniProtKB:Q9JJS8}.; PTM: Activated by cleavage after Arg-443 by MASP1. The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cleavage. {ECO:0000250|UniProtKB:O00187}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10586086
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15672593
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16944957
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9794427
uniprot
proteins
sequence_length
685
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O00187}.; SUBCELLULAR LOCATION: [Mannan-binding lectin serine protease 2 B chain]: Secreted {ECO:0000250|UniProtKB:O00187}. Cell surface {ECO:0000250|UniProtKB:O00187}. Note=Recruited to the surface of pathogens by the mannose-binding proteins, such as MBL2. {ECO:0000250|UniProtKB:O00187}.
uniprot
proteins