Cenatac
entrez
382073
canonical
uniprot
Q4VA36
canonical
ensembl
ENSMUSG00000043923
resolver
ensp
ENSMUSP00000053216
resolver
ensp
ENSMUSP00000208315
resolver
ensp
ENSMUSP00000208323
resolver
genesymbol
Cenatac
resolver
genesymbol_syn
Ccdc84
resolver
uniprot
Q3TAL6
resolver
uniprot
Q7TNQ4
resolver
uniprot
Q8C702
resolver
uniprot_entry
CATAC_MOUSE
resolver
uniprot_sec
Q3TAL6
resolver
uniprot_sec
Q7TNQ4
resolver
uniprot_sec
Q8C702
resolver
amino_acid_sequence
MAPPQRCPLCRQTFFCGRGHVYSHKHQRQLKGALERLLPQVEAARRAVRAAQVERYVPEHDRCCWCPCCGCEVRKHLSHGNLTVLHGGLLEHLASPEHKKATNKFWWENKANAQMKEKFLISPQDYARFKKSMVKGLDSYEEKEDEVIKEMAAQIREVEQSRQEVVRSVLEPQAESDPEEGSSAPESWKATNGHVASSSQQVSHLALQPVAELDWMETGQQLTFIGHQDTPGIGNIHSGATPPWMIQEEEHSSGSLPIGPSYEEFLKEKEKQKLKKLPPDRVGANFDHSSNTSAGWLPSFGRVWNNGRRWQSRHQFKTEAATRSKQPRKGKS
uniprot
proteins
function
FUNCTION: Component of the minor spliceosome that promotes splicing of a specific, rare minor intron subtype. Negative regulator of centrosome duplication. Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1. {ECO:0000250|UniProtKB:Q86UT8}.
uniprot
proteins
mass_dalton
37701
uniprot
proteins
post_translational_modification
PTM: Acetylated. Acetylation oscillates throughout the cell cycle, and the acetylation state at Lys-31 is regulated by the deacetylase SIRT1 and the acetyltransferase NAT10. Deacetylated CENATAC is responsible for its centrosome targeting, and acetylated CENATAC promotes SASS6 degradation by enhancing the binding affinity of SASS6 for APC/C E3 ubiquitin-protein ligase complex/FZR1. {ECO:0000250|UniProtKB:Q86UT8}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
332
uniprot
proteins