SPPL2C
entrez
162540
canonical
uniprot
Q8IUH8
canonical
ensembl
ENSG00000185294
resolver
ensp
ENSP00000332488
resolver
enst
ENST00000329196
resolver
genesymbol
SPPL2C
resolver
genesymbol_syn
IMP5
resolver
hgnc
HGNC:28902
resolver
uniprot
Q8TC67
resolver
uniprot
Q8WVZ6
resolver
uniprot_entry
SPP2C_HUMAN
resolver
uniprot_sec
Q8TC67
resolver
uniprot_sec
Q8WVZ6
resolver
amino_acid_sequence
MACLGFLLPVGFLLLISTVAGGKYGVAHVVSENWSKDYCILFSSDYITLPRDLHHAPLLPLYDGTKAPWCPGEDSPHQAQLRSPSQRPLRQTTAMVMRGNCSFHTKGWLAQGQGAHGLLIVSRVSDQQCSDTTLAPQDPRQPLADLTIPVAMLHYADMLDILSHTRGEAVVRVAMYAPPEPIIDYNMLVIFILAVGTVAAGGYWAGLTEANRLQRRRARRGGGSGGHHQLQEAAAAEGAQKEDNEDIPVDFTPAMTGVVVTLSCSLMLLLYFFYDHFVYVTIGIFGLGAGIGLYSCLSPLVCRLSLRQYQRPPHSLWASLPLPLLLLASLCATVIIFWVAYRNEDRWAWLLQDTLGISYCLFVLHRVRLPTLKNCSSFLLALLAFDVFFVFVTPFFTKTGESIMAQVALGPAESSSHERLPMVLKVPRLRVSALTLCSQPFSILGFGDIVVPGFLVAYCCRFDVQVCSRQIYFVACTVAYAVGLLVTFMAMVLMQMGQPALLYLVSSTLLTSLAVAACRQELSLFWTGQGRAKMCGLGCAPSAGSRQKQEGAADAHTASTLERGTSRGAGDLDSNPGEDTTEIVTISENEATNPEDRSDSSEGWSDAHLDPNELPFIPPGASEELMPLMPMAMLIPLMPLMPPPSELGHVHAQAQAHETGLPWAGLHKRKGLKVRKSMSTQAPL
uniprot
proteins
ec_number
3.4.23.-
uniprot
proteins
function
FUNCTION: Sperm-specific intramembrane-cleaving aspartic protease (I-CLiP) that cleaves distinct tail-anchored proteins and SNARE proteins (PubMed:30733281). In elongated spermatids, modulates intracellular Ca(2+) homeostasis by controlling PLN abundance through proteolytic cleavage (By similarity). During spermatogenesis, processes SNARE proteins and impacts vesicular trafficking which supports compartmental reorganization in maturating spermatids and may play a role in formation of the acrosome (PubMed:30733281). {ECO:0000250|UniProtKB:A2A6C4, ECO:0000269|PubMed:30733281}.; FUNCTION: In round spermatids, acts as a scaffold protein supporting FREY1 in IZUMO1 recruitment at the endoplasmic reticulum membrane and coordination of IZUMO1 complex assembly. Stabilizes FREY1 at the endoplasmic reticulum membrane through interaction. May recruit IZUMO1 interaction partners. {ECO:0000250|UniProtKB:A2A6C4}.
uniprot
proteins
mass_dalton
74503
uniprot
proteins
mutagenesis
MUTAGEN 448; /note="D->A: Loss of aspartyl protease activity."; /evidence="ECO:0000269|PubMed:30733281
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:15385547}.
uniprot
proteins
protein_family
Peptidase A22B family
uniprot
proteins
pubmed
12139484
uniprot
proteins
pubmed
15385547
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16829952
uniprot
proteins
pubmed
30733280
uniprot
proteins
pubmed
30733281
uniprot
proteins
sequence_length
684
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:30733280, ECO:0000269|PubMed:30733281}; Multi-pass membrane protein {ECO:0000255}; Lumenal side {ECO:0000269|PubMed:15385547, ECO:0000269|PubMed:16829952}.
uniprot
proteins
transmembrane_region
TRANSMEM 187..207; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 254..274; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 320..340; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 347..365; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 440..460; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 473..493; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 496..516; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins