Nudt4
entrez
94267
canonical
uniprot
Q99MY2
canonical
ensembl
ENSRNOG00000009094
resolver
ensp
ENSRNOP00000012363
resolver
ensp
ENSRNOP00000078797
resolver
genesymbol
Nudt4
resolver
genesymbol_syn
Dipp2
resolver
uniprot_entry
NUDT4_RAT
resolver
amino_acid_sequence
MKFKPNQTRTYDREGFKKRAACLCFRSEQEDEVLLVSSSRYPDQWIVPGGGVEPEEEPGGAAAREVYEEAGVKGKLGRLLGIFENQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREWFKVEDAIKVLQCHKPVHAEYLERLKLGCSPTNGNSTVPSLPDNNALFVTAAPPSGVPSSIR
uniprot
proteins
ec_number
3.6.1.52
uniprot
proteins
ec_number
3.6.1.61
uniprot
proteins
function
FUNCTION: Cleaves the beta-phosphate from diphosphoinositol polyphosphates such as PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 (diphosphoinositol tetrakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Diadenosine polyphosphates, particularly Ap6A (P(1),P(6)-bis(5a-adenosyl) hexaphosphate) and Ap5A (P(1),P(5)-bis(5'-adenosyl) pentaphosphate) are downstream effectors of a signaling cascade that regulates cardiac KATP channels, can also be substrates, although with lower preference than the diphosphoinositol polyphosphates. Can also catalyze the hydrolysis of 5-phosphoribose 1-diphosphate, generating the glycolytic activator ribose 1,5-bisphosphate (By similarity). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250|UniProtKB:Q8R2U6, ECO:0000250|UniProtKB:Q9NZJ9}.
uniprot
proteins
mass_dalton
20138
uniprot
proteins
protein_family
DIPP subfamily
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
11331144
uniprot
proteins
sequence_length
179
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NZJ9}.
uniprot
proteins