SLCO3A1
entrez
28232
canonical
uniprot
Q9UIG8
canonical
ensembl
ENSG00000176463
resolver
ensp
ENSP00000320634
resolver
ensp
ENSP00000387846
resolver
genesymbol
SLCO3A1
resolver
genesymbol_syn
OATP3A1
resolver
genesymbol_syn
OATPD
resolver
genesymbol_syn
SLC21A11
resolver
hgnc
HGNC:10952
resolver
uniprot
A8K4A7
resolver
uniprot
B3KPY5
resolver
uniprot
B3KUR7
resolver
uniprot
C6G486
resolver
uniprot
Q9BW73
resolver
uniprot
Q9GZV2
resolver
uniprot_entry
SO3A1_HUMAN
resolver
uniprot_sec
A8K4A7
resolver
uniprot_sec
B3KPY5
resolver
uniprot_sec
B3KUR7
resolver
uniprot_sec
C6G486
resolver
uniprot_sec
Q9BW73
resolver
uniprot_sec
Q9GZV2
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by extracellular acidic pH. {ECO:0000269|PubMed:19129463}.
uniprot
proteins
amino_acid_sequence
MQGKKPGGSSGGGRSGELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFLCVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHEGGLSTSEFFASTLTLDNLGRDPVPANQTHRTKFIYNLEDHEWCENMESVL
uniprot
proteins
function
FUNCTION: Putative organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormone L-thyroxine, prostanoids such as prostaglandin E1 and E2, bile acids such as taurocholate, glycolate and glycochenodeoxycholate and peptide hormones such as L-arginine vasopressin, likely operating in a tissue-specific manner (PubMed:10873595, PubMed:14631946, PubMed:16971491, PubMed:19129463, PubMed:30063921). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). Mediates transport of tryptophan, phenyalanine and tyrosine (PubMed:39206635). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:14631946, ECO:0000269|PubMed:16971491, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:30063921, ECO:0000269|PubMed:39206635, ECO:0000305}.; FUNCTION: [Isoform 1]: Mediates transport of steroid hormone precursors dehydroepiandrosterone 3-sulfate and estrone 3-sulfate. {ECO:0000269|PubMed:36120371}.; FUNCTION: [Isoform 2]: Mediates transport of steroid hormone precursors dehydroepiandrosterone 3-sulfate and estrone 3-sulfate. {ECO:0000269|PubMed:36120371}.; FUNCTION: [Isoform 5]: Mediates transport of steroid hormone precursors dehydroepiandrosterone 3-sulfate and estrone 3-sulfate. {ECO:0000269|PubMed:36120371}.
uniprot
proteins
mass_dalton
76553
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
10873595
uniprot
proteins
pubmed
12409283
uniprot
proteins
pubmed
14631946
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
16971491
uniprot
proteins
pubmed
19129463
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25732826
uniprot
proteins
pubmed
30063921
uniprot
proteins
pubmed
35307651
uniprot
proteins
pubmed
36120371
uniprot
proteins
pubmed
39206635
uniprot
proteins
sequence_length
710
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Basolateral cell membrane {ECO:0000269|PubMed:16971491, ECO:0000269|PubMed:36120371}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the basolateral membrane of choroid plexus epithelium. {ECO:0000269|PubMed:16971491}.; SUBCELLULAR LOCATION: [Isoform 2]: Apical cell membrane {ECO:0000269|PubMed:16971491}; Multi-pass membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the basal membrane of Sertoli cells (PubMed:35307651). Localized to the apical membrane of choroid plexus epithelium (PubMed:16971491). {ECO:0000269|PubMed:16971491, ECO:0000269|PubMed:35307651}.; SUBCELLULAR LOCATION: [Isoform 5]: Apical cell membrane {ECO:0000269|PubMed:36120371}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 41..60; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 80..100; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 107..131; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 175..203; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 223..243; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 262..286; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 345..366; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 387..410; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 415..438; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 540..562; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 572..597; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 631..648; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins