Csnk1a1
entrez
93687
canonical
uniprot
Q8BK63
canonical
ensembl
ENSMUSG00000024576
resolver
ensp
ENSMUSP00000110901
resolver
ensp
ENSMUSP00000127265
resolver
ensp
ENSMUSP00000127463
resolver
ensp
ENSMUSP00000128871
resolver
ensp
ENSMUSP00000132083
resolver
ensp
ENSMUSP00000228773
resolver
ensp
ENSMUSP00000228788
resolver
ensp
ENSMUSP00000346244
resolver
ensp
ENSMUSP00000354551
resolver
enst
ENSMUST00000115246
resolver
enst
ENSMUST00000167187
resolver
enst
ENSMUST00000170862
resolver
genesymbol
Csnk1a1
resolver
uniprot
E9Q2U6
resolver
uniprot
E9Q3W1
resolver
uniprot
H7BXB1
resolver
uniprot
Q3UIL0
resolver
uniprot
Q64506
resolver
uniprot
Q6PJ87
resolver
uniprot
Q80XI2
resolver
uniprot
Q99LY3
resolver
uniprot_entry
E9Q2U6_MOUSE
resolver
uniprot_entry
E9Q3W1_MOUSE
resolver
uniprot_entry
H7BXB1_MOUSE
resolver
uniprot_entry
KC1A_MOUSE
resolver
uniprot_entry
Q6PJ87_MOUSE
resolver
uniprot_sec
Q3UIL0
resolver
uniprot_sec
Q64506
resolver
uniprot_sec
Q80XI2
resolver
uniprot_sec
Q99LY3
resolver
amino_acid_sequence
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (By similarity). Phosphorylates a large number of proteins (By similarity). Participates in Wnt signaling (By similarity). Phosphorylates CTNNB1 at 'Ser-45' (By similarity). May phosphorylate PER1 and PER2 (PubMed:21930935). May play a role in segregating chromosomes during mitosis (By similarity). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (By similarity). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (By similarity). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34615873). {ECO:0000250|UniProtKB:P48729, ECO:0000269|PubMed:21930935, ECO:0000269|PubMed:34615873}.
uniprot
proteins
mass_dalton
38915
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MTOR in response to mitogenic stimulation, leading to its activation (By similarity). Recognized by CRBN and is targeted for degradation by DCX (DDB1-CUL4-X-box) E3 protein ligase complex (By similarity). {ECO:0000250|UniProtKB:P48729}.
uniprot
proteins
protein_family
CK1 Ser/Thr protein kinase family
uniprot
proteins
protein_family
Casein kinase I subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21930935
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
25644602
uniprot
proteins
pubmed
31338967
uniprot
proteins
pubmed
34615873
uniprot
proteins
pubmed
35931121
uniprot
proteins
pubmed
39868537
uniprot
proteins
pubmed
9522121
uniprot
proteins
sequence_length
337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P48729}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P48729}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P48729}. Nucleus speckle {ECO:0000250|UniProtKB:P48729}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:25644602}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:31338967}. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton. {ECO:0000250|UniProtKB:P48729}.
uniprot
proteins