Gpr171
entrez
688737
canonical
uniprot
D4A4Q2
canonical
ensembl
ENSRNOG00000025297
resolver
ensembl
ENSRNOG00055018719
resolver
ensembl
ENSRNOG00060004962
resolver
ensembl
ENSRNOG00065024441
resolver
ensp
ENSRNOP00000038911
resolver
ensp
ENSRNOP00000080055
resolver
ensp
ENSRNOP00055025772
resolver
ensp
ENSRNOP00055025777
resolver
ensp
ENSRNOP00060006223
resolver
ensp
ENSRNOP00060006226
resolver
ensp
ENSRNOP00065034231
resolver
ensp
ENSRNOP00065034247
resolver
enst
ENSRNOT00000036690
resolver
enst
ENSRNOT00000102875
resolver
enst
ENSRNOT00055031875
resolver
enst
ENSRNOT00055031880
resolver
enst
ENSRNOT00060008277
resolver
enst
ENSRNOT00060008282
resolver
enst
ENSRNOT00065041889
resolver
enst
ENSRNOT00065041908
resolver
genesymbol
Gpr171
resolver
uniprot_entry
GP171_RAT
resolver
amino_acid_sequence
MTNSSMFCPIYRDLEPFTYFFYLVYLIGIIGSCFATWAFIQKSTNHRCVSIYLINLLTADFLLTLALPVKIVVDLGVAPWKLRIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLVHSCKIYRIQEPGFAKMISAVVWLMVLLIMVPNMVIPIKNIKEKSNVGCMEFKREFGKNWHLLTNFICVAIFLNFSAIILISNFLVIRQLYRNRDNANYPSVKSALLNILLVTASYIICFVPYHAVRIPYTLSQTEVISDCSTRIALFKAKEATLLLAVSNLCFDPILYYHLSKAFRLKVTETFASPQKMKAREEKPRRENDVQSTGSAC
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N) (PubMed:24043826). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception. Acts as a negative regulator T cell function (By similarity). {ECO:0000250|UniProtKB:Q8BG55, ECO:0000269|PubMed:24043826}.
uniprot
proteins
mass_dalton
37405
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
24043826
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24043826}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalized with GPR83 in the paraventricular nucleus. {ECO:0000250|UniProtKB:Q8BG55}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 49..69; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 134..154; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 222..242; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins