Mt-co2
entrez
17709
canonical
uniprot
P00405
canonical
ensembl
ENSMUSG00000064354
resolver
ensp
ENSMUSP00000080994
resolver
enst
ENSMUST00000082405
resolver
genesymbol
Mt-co2
resolver
genesymbol_syn
COII
resolver
genesymbol_syn
COX2
resolver
uniprot
Q85K21
resolver
uniprot_entry
COX2_MOUSE
resolver
uniprot_sec
Q85K21
resolver
amino_acid_sequence
MAYPFQLGLQDATSPIMEELMNFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAVILIMIALPSLRILYMMDEINNPVLTVKTMGHQWYWSYEYTDYEDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKYFENWSASMI
uniprot
proteins
ec_number
7.1.1.9
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}.
uniprot
proteins
mass_dalton
25976
uniprot
proteins
protein_family
Cytochrome c oxidase subunit 2 family
uniprot
proteins
pubmed
12954771
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34616041
uniprot
proteins
pubmed
38575788
uniprot
proteins
pubmed
7332926
uniprot
proteins
pubmed
8281018
uniprot
proteins
sequence_length
227
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}; Multi-pass membrane protein {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..44; /note="Helical; Name=I"; /evidence="ECO:0000269|PubMed:34616041, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C"; TRANSMEM 61..81; /note="Helical; Name=II"; /evidence="ECO:0000269|PubMed:34616041, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C
uniprot
proteins