Tmem120a
entrez
215210
canonical
uniprot
Q8C1E7
canonical
ensembl
ENSMUSG00000039886
resolver
ensp
ENSMUSP00000045252
resolver
enst
ENSMUST00000043378
resolver
genesymbol
Tmem120a
resolver
genesymbol_syn
Net29
resolver
genesymbol_syn
Tacan
resolver
uniprot
Q8BWP7
resolver
uniprot_entry
TACAN_MOUSE
resolver
uniprot_sec
Q8BWP7
resolver
amino_acid_sequence
MQSPPPDPLGDCLRNWEDLQQDFQGIQETHRLYRLKLEELTKLQANCTNSITRQKKRLQELALVLKKCRPSLPSESMEAAQELENQMKERQGLFFDMEAYLPKKNGLYLSLVLGNVNVTLLSKQAKFAYKDEYEKFKLYLTIILIVISFTCRFLLNSRVTDAAFNFLLVWYYCTLTIRESILINNGSRIKGWWVFHHYVSTFLSGVMLTWPDGLMYQKFRNQFLSFSMYQSFVQFLQYYYQSGCLYRLRALGERHTMDLTVEGFQSWMWRGLTFLLPFLFFGHFWQLFNALTLFNLARDPECKEWQVLMCGFPFLLLFLGNFFTTLRVVHQKFHSQQHGNKKD
uniprot
proteins
function
FUNCTION: Multifunctional protein involved in mechanosensation, and plays an essential role in lipid metabolism and adipocyte differentiation (PubMed:26024229, PubMed:32084332, PubMed:34731626, PubMed:35027552, PubMed:39147733). May function as a potential ion channel involved in sensing mechanical stimuli (By similarity). Mediates the mechanosensitivity of the PKD2-TMEM120A channel complex through direct physical interaction (By similarity). TMEM120A seems to affect mechanosensation by inhibiting PIEZO2 channels, possibly by altering cellular lipid content (PubMed:35819364, PubMed:39147733). TMEM120A is structurally similar to a lipid-modifying enzyme, ELOVL7, and contains a bound coenzyme A molecule, which suggests it might function as an enzyme in lipid metabolism (PubMed:34374644). {ECO:0000250|UniProtKB:Q9BXJ8, ECO:0000269|PubMed:26024229, ECO:0000269|PubMed:32084332, ECO:0000269|PubMed:34374644, ECO:0000269|PubMed:34731626, ECO:0000269|PubMed:35027552, ECO:0000269|PubMed:35819364, ECO:0000269|PubMed:39147733}.
uniprot
proteins
mass_dalton
40751
uniprot
proteins
mutagenesis
MUTAGEN 193; /note="W->A: Reduces its inhibitory effect on PIEZO2. Reduces its inhibitory effect of PIEZO2; when associated with A-196 and A-197."; /evidence="ECO:0000269|PubMed:39147733"; MUTAGEN 196; /note="H->A: Reduces its inhibitory effect on PIEZO2; when associated with A-193 and A-197. Shifts its ability to interact with larger CoA species (S-ethyl- CoA and acetyl-CoA); when associated with A-197."; /evidence="ECO:0000269|PubMed:34374644, ECO:0000269|PubMed:39147733"; MUTAGEN 197; /note="H->A: Reduces its inhibitory effect on PIEZO2; when associated with A-193 and A-196. Shifts its ability to interact with larger CoA species (S-ethyl- CoA and acetyl-CoA); when associated with A-196."; /evidence="ECO:0000269|PubMed:34374644, ECO:0000269|PubMed:39147733
uniprot
proteins
protein_family
TMEM120 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20091084
uniprot
proteins
pubmed
26024229
uniprot
proteins
pubmed
32084332
uniprot
proteins
pubmed
34374644
uniprot
proteins
pubmed
34731626
uniprot
proteins
pubmed
35013224
uniprot
proteins
pubmed
35027552
uniprot
proteins
pubmed
35819364
uniprot
proteins
pubmed
39147733
uniprot
proteins
sequence_length
343
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32084332, ECO:0000269|PubMed:39147733}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BXJ8}. Nucleus envelope {ECO:0000269|PubMed:20091084}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q9BXJ8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BXJ8}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9BXJ8}.
uniprot
proteins
transmembrane_region
TRANSMEM 136..156; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 191..211; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 223..240; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 274..294; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 306..326; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins