Scnn1b
entrez
20277
canonical
uniprot
Q9WU38
canonical
ensembl
ENSMUSG00000030873
resolver
ensp
ENSMUSP00000033161
resolver
ensp
ENSMUSP00000310666
resolver
enst
ENSMUST00000033161
resolver
genesymbol
Scnn1b
resolver
uniprot
A2RS45
resolver
uniprot_entry
A2RS45_MOUSE
resolver
uniprot_entry
SCNNB_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Originally identified and characterized by its inhibition by the diuretic drug amiloride. {ECO:0000269|PubMed:10409305}.
uniprot
proteins
amino_acid_sequence
MPVKKYLLKCLHRLQKGPGYTYKELLVWYCNNTNTHGPKRIICEGPKKKAMWFLLTLLFACLVCWQWGVFIQTYLSWEVSVSLSMGFKTMNFPAVTVCNSSPFQYSKVKHLLKDLDELMEAVLEKILAPEASHSNTTRTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMRLCSANGTVCTLRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILACLFGTEPCSHRNFTPIFYPDYGNCYIFNWGMTEETLPSANPGTEFGLKLILDIGQEDYVPFLASTAGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLVDKLQRKGEPYSPCTMNGSDVAIKNLYSVYNTTYSIQACLHSCFQDHMIRNCSCGHYLYPLPEGEKYCNNRDFPDWAYCYLNLQMSVTQRETCLSMCKESCNDTQYKMTISMADWPSEASEDWILHVLSQERDQSSNITLSRKGIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITIIKLVASCKGLRRRRPQAPYTGPPPTVAELVEAHTNFGFQPDTTSCRPHGEVYPDQQTLPIPGTPPPNYDSLRLQPLDTMESDSEVEAI
uniprot
proteins
function
FUNCTION: This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:10409305). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:9990092). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (PubMed:9990092). This subunit is not essential for ENaC function in airway surface liquid homeostasis and proper mucus clearance (PubMed:9990092). {ECO:0000269|PubMed:10409305, ECO:0000269|PubMed:9990092}.
uniprot
proteins
mass_dalton
72197
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Can be ubiquitinated at multiple sites and undergo monoubiquitination and polyubiquitination. Ubiquitination by NEDD4 or NEDD4L inhibits the ENaC channel through endocytosis, intracellular retention and degradation of its individual subunits (PubMed:11244092, PubMed:12424229, PubMed:15123669). However, some studies could not confirm the ubiquitination of this subunit of the ENaC (By similarity). {ECO:0000250|UniProtKB:P37090, ECO:0000269|PubMed:11244092, ECO:0000269|PubMed:12424229, ECO:0000269|PubMed:15123669}.; PTM: N-glycosylated. N-glycosylation is required for interaction with BPIFA1. {ECO:0000250|UniProtKB:P51168}.; PTM: Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. {ECO:0000250|UniProtKB:P37090}.
uniprot
proteins
protein_family
Amiloride-sensitive sodium channel (TC 1.A.6) family
uniprot
proteins
protein_family
SCNN1B subfamily
uniprot
proteins
pubmed
10409305
uniprot
proteins
pubmed
11244092
uniprot
proteins
pubmed
12424229
uniprot
proteins
pubmed
15123669
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9990092
uniprot
proteins
sequence_length
638
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P51168}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51168}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P37090}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51168}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..71; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 531..551; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins