Lrfn1
entrez
365222
canonical
uniprot
P0C7J6
canonical
ensembl
ENSRNOG00000019869
resolver
ensp
ENSRNOP00000053905
resolver
enst
ENSRNOT00000057073
resolver
genesymbol
Lrfn1
resolver
genesymbol_syn
Salm2
resolver
uniprot_entry
LRFN1_RAT
resolver
amino_acid_sequence
MAPGPFSSGLLSPPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRKVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGGGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSDIATPGRPGANDSATERRLVAAELTSSSVLIRWPAQRPVPGIRMYQVQYNSSADDSLVYRMIPSTSQTFLVNDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGGVIVASVLVFIVLLMIRYKVYGDGDSRRIKGTSRSPPRVSHVCSQTNGSSAQQASAPPAPDRYEALREVAVPAAIEAKAMEAEATSTELEVVLGRSLGGSATSLCLLPSEETSGEESRAVTGPRRSRSGALGPPTSAPPTLALVRGGSPARPRPQQRYSFDGDYGALFQSHSYPRRARRTKRHRSTPHLDGAGGGAAGEDGDLGLGSARARLAFTSTEWMLESTV
uniprot
proteins
function
FUNCTION: Promotes neurite outgrowth in hippocampal neurons (By similarity). Involved in the regulation of the differentiation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1. {ECO:0000250, ECO:0000269|PubMed:16630835}.
uniprot
proteins
mass_dalton
81970
uniprot
proteins
mutagenesis
MUTAGEN 764..766; /note="Missing: Loss of DLG1-, DLG3- and DLG4-binding."; /evidence="ECO:0000269|PubMed:16630835
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:16630835}.
uniprot
proteins
protein_family
LRFN family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16630835
uniprot
proteins
pubmed
18227064
uniprot
proteins
sequence_length
766
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:16630835}; Single-pass type I membrane protein {ECO:0000269|PubMed:16630835}. Synapse {ECO:0000269|PubMed:16630835}. Postsynaptic density membrane {ECO:0000269|PubMed:16630835}. Note=Detected in excitatory, but not inhibitory, synaptic plasma membrane.
uniprot
proteins
transmembrane_region
TRANSMEM 537..557; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins