CHSY3
entrez
337876
canonical
uniprot
Q70JA7
canonical
ensembl
ENSG00000198108
resolver
ensp
ENSP00000302629
resolver
enst
ENST00000305031
resolver
genesymbol
CHSY3
resolver
genesymbol_syn
CHSY2
resolver
genesymbol_syn
CSS3
resolver
hgnc
HGNC:24293
resolver
uniprot
B2RP97
resolver
uniprot
Q76L22
resolver
uniprot
Q86Y52
resolver
uniprot_entry
CHSS3_HUMAN
resolver
uniprot_sec
B2RP97
resolver
uniprot_sec
Q76L22
resolver
uniprot_sec
Q86Y52
resolver
amino_acid_sequence
MAVRSRRPWMSVALGLVLGFTAASWLIAPRVAELSERKRRGSSLCSYYGRSAAGPRAGAQQPLPQPQSRPRQEQSPPPARQDLQGPPLPEAAPGITSFRSSPWQQPPPLQQRRRGREPEGATGLPGAPAAEGEPEEEDGGAAGQRRDGRPGSSHNGSGDGGAAAPSARPRDFLYVGVMTAQKYLGSRALAAQRTWARFIPGRVEFFSSQQPPNAGQPPPPLPVIALPGVDDSYPPQKKSFMMIKYMHDHYLDKYEWFMRADDDVYIKGDKLEEFLRSLNSSKPLYLGQTGLGNIEELGKLGLEPGENFCMGGPGMIFSREVLRRMVPHIGECLREMYTTHEDVEVGRCVRRFGGTQCVWSYEMQQLFHENYEHNRKGYIQDLHNSKIHAAITLHPNKRPAYQYRLHNYMLSRKISELRYRTIQLHRESALMSKLSNTEVSKEDQQLGVIPSFNHFQPRERNEVIEWEFLTGKLLYSAAENQPPRQSLSSILRTALDDTVLQVMEMINENAKSRGRLIDFKEIQYGYRRVNPMHGVEYILDLLLLYKRHKGRKLTVPVRRHAYLQQLFSKPFFRETEELDVNSLVESINSETQSFSFISNSLKILSSFQGAKEMGGHNEKKVHILVPLIGRYDIFLRFMENFENMCLIPKQNVKLVIILFSRDSGQDSSKHIELIKGYQNKYPKAEMTLIPMKGEFSRGLGLEMASAQFDNDTLLLFCDVDLIFREDFLQRCRDNTIQGQQVYYPIIFSQYDPKVTNGGNPPTDDYFIFSKKTGFWRDYGYGITCIYKSDLLGAGGFDTSIQGWGLEDVDLYNKVILSGLRPFRSQEVGVVHIFHPVHCDPNLDPKQYKMCLGSKASTFASTMQLAELWLEKHLGVRYNRTLS
uniprot
proteins
ec_number
2.4.1.175
uniprot
proteins
ec_number
2.4.1.226
uniprot
proteins
function
FUNCTION: Catalytic component of CHSY1-CHPF2 and CHSY1-CHPF chondroitin sulfate synthase complexes (PubMed:41298522). Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1. {ECO:0000269|PubMed:12907687, ECO:0000269|PubMed:41298522}.
uniprot
proteins
mass_dalton
100284
uniprot
proteins
mutagenesis
MUTAGEN 261; /note="D->N: Unable to catalyze GlcA transfer; when associated with N-263."; /evidence="ECO:0000269|PubMed:41298522"; MUTAGEN 263; /note="D->N: Unable to catalyze GlcA transfer; when associated with N-261."; /evidence="ECO:0000269|PubMed:41298522"; MUTAGEN 394; /note="H->A: Unable to catalyze GlcA transfer."; /evidence="ECO:0000269|PubMed:41298522"; MUTAGEN 718; /note="D->N: Unable to transfer GalNAc residues; when associated with N-720."; /evidence="ECO:0000269|PubMed:41298522"; MUTAGEN 720; /note="D->N: Unable to transfer GalNAc residues; when associated with N-718."; /evidence="ECO:0000269|PubMed:41298522"; MUTAGEN 831; /note="H->A: Unable to transfer GalNAc residues."; /evidence="ECO:0000269|PubMed:41298522
uniprot
proteins
protein_family
Chondroitin N-acetylgalactosaminyltransferase family
uniprot
proteins
pubmed
12907687
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
41298522
uniprot
proteins
sequence_length
882
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000305|PubMed:12907687}; Single-pass type II membrane protein {ECO:0000305|PubMed:12907687}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins