C0HM02
uniprot
C0HM02
canonical
amino_acid_sequence
MASRGALRRCLSPGLPRLLHLSRGLA
uniprot
proteins
function
FUNCTION: Product of an upstream open reading frame (ORF) of PRKCH which regulates translation of the downstream protein kinase C eta (PKC-eta) ORF (PubMed:19797084, PubMed:34593629). Functions as a repressive element that maintains low basal levels of PKC-eta in growing cells but enhances its expression during stress conditions induced by amino acid starvation in a EIF2AK4/GCN2-dependent manner (PubMed:19797084, PubMed:34593629). In addition to its role in regulating PKC-eta translation, also inhibits the kinase activity of PKC-eta as well as other protein kinases including PRKCD, PRKCQ and PRKCE but not PRKCA, PRKCG or PRKCZ (PubMed:34593629). {ECO:0000269|PubMed:19797084, ECO:0000269|PubMed:34593629}.
uniprot
proteins
mass_dalton
2802
uniprot
proteins
mutagenesis
MUTAGEN 6; /note="A->S,T: Abolishes kinase inhibitor activity and converts peptide to a substrate for PRKCH and PRKCE but not for PRKCA."; /evidence="ECO:0000269|PubMed:34593629
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
19797084
uniprot
proteins
pubmed
34593629
uniprot
proteins
sequence_length
26
uniprot
proteins