Plbd1
entrez
66857
canonical
uniprot
Q8VCI0
canonical
ensembl
ENSMUSG00000030214
resolver
ensp
ENSMUSP00000032336
resolver
ensp
ENSMUSP00000279683
resolver
genesymbol
Plbd1
resolver
uniprot
A0A0R4J0B2
resolver
uniprot
Q3TA89
resolver
uniprot
Q9D1S0
resolver
uniprot_entry
LYLAP_MOUSE
resolver
uniprot_sec
A0A0R4J0B2
resolver
uniprot_sec
Q3TA89
resolver
uniprot_sec
Q9D1S0
resolver
amino_acid_sequence
MCHRSPGRSLRPPSPLLLLLPLLLQPPWAAGAASQSDPTGVHCATAYWSPESKKVEIKTVLDKNGDAYGYYNDSIKTTGWGILEIRAGYGSQVLSNEIIMFLAGYLEGYLTALHMYDHFTNLYPQLFKNPSIVKKVQDFMEKQEMWTRQNIKAQKDDPFWRHTGYVVTQLDGLYLGAQKRASEEKIKPMTMFQIQFLNAVGDLLDLIPSLSPTKSSSMMKFKIWEMGHCSALIKVLPGFENIYFAHSSWYTYAAMLRIYKHWDFNIKDKYTLSKRLSFSSYPGFLESLDDFYILSSGLILLQTTNSVYNKTLLKQVVPKTLLAWQRVRVANMMAEGGKEWAQIFSKHNSGTYNNQYMVLDLKKVTINRSLDKGTLYIVEQIPTYVEYSDQTNVLRKGYWASYNIPFHKTIYNWSGYPLLVHKLGLDYSYDLAPRAKIFRRDQGNVTDMASMKYIMRYNNYKEDPYSKGDPCSTICCREDLNGASPSPGGCYDTKVADIFLASQYKAYAISGPTVQDGLPPFNWNRFNDTLHRGMPEVFDFNFVTMKPILS
uniprot
proteins
ec_number
3.4.11.-
uniprot
proteins
function
FUNCTION: Lysosomal processive monoaminopeptidase that preferentially cleaves hydrophobic amino acids, with strong preference for leucine residues. Plays a key role in the degradation of hydrophobic transmembrane domains within the lysosome. {ECO:0000250|UniProtKB:Q6P4A8}.
uniprot
proteins
mass_dalton
63018
uniprot
proteins
post_translational_modification
PTM: Proteolytically activated within lysosomes. Undergoes autocatalytic cleavage into an N-terminal A chain and a C-terminal B chain. Both chains A and B remain associated in the mature protein. An additional maturation step involves the removal of a segment spanning residues Leu-210-228-Cys, which occludes the active site. {ECO:0000250|UniProtKB:Q6P4A8}.
uniprot
proteins
protein_family
Ntn-hydrolase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16170054
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
550
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q9GL30}.
uniprot
proteins