Pdlim4
entrez
24915
canonical
uniprot
P36202
canonical
ensembl
ENSRNOG00000050794
resolver
ensp
ENSRNOP00000064261
resolver
ensp
ENSRNOP00000086241
resolver
enst
ENSRNOT00000074616
resolver
enst
ENSRNOT00000101447
resolver
genesymbol
Pdlim4
resolver
genesymbol_syn
Ril
resolver
uniprot
A0A8I6GEQ8
resolver
uniprot
M0R4H5
resolver
uniprot_entry
A0A8I6GEQ8_RAT
resolver
uniprot_entry
M0R4H5_RAT
resolver
uniprot_entry
PDLI4_RAT
resolver
amino_acid_sequence
MTHAVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDSIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPENKNWPSSPNDKAQAHRIHIDPEAQDGSPATSRRSSISGISLEDNRSGLGSPYGQPPRLPVPHNGSSNEVTLPSQMSALHVSPPPSADTPRILPRNRDCRVDLGSEVYRMLREPAEPAASEPKQSGSFRYLQGMLEAGEGGDRPGSGGSRNLKPAASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCENHAKARVKPPEGYDVVAVYPNAKVELV
uniprot
proteins
function
FUNCTION: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (By similarity). Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers (PubMed:14729062, PubMed:22659164). Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (PubMed:15456832). {ECO:0000250|UniProtKB:P50479, ECO:0000269|PubMed:14729062, ECO:0000269|PubMed:15456832, ECO:0000269|PubMed:22659164}.
uniprot
proteins
mass_dalton
35521
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residue(s). Can be dephosphorylated by PTPN13. {ECO:0000250|UniProtKB:P70271}.
uniprot
proteins
pubmed
14729062
uniprot
proteins
pubmed
15456832
uniprot
proteins
pubmed
22659164
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7824279
uniprot
proteins
sequence_length
330
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14729062, ECO:0000269|PubMed:15456832, ECO:0000269|PubMed:22659164}. Cell projection, dendritic spine {ECO:0000269|PubMed:15456832}. Early endosome membrane {ECO:0000269|PubMed:15456832}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Recycling endosome membrane {ECO:0000269|PubMed:15456832}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Nucleus {ECO:0000250|UniProtKB:P50479}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P50479}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P50479}. Synapse, synaptosome {ECO:0000269|PubMed:15456832}. Note=Localizes to actin stress fibers in nonmuscle cells (PubMed:14729062, PubMed:22659164). Colocalizes with GRIA1 in early endosomes. Enriched in numerous but not all spine-like structures along dendritic branches. Colocalizes with actin and enriched at sites containing larger amounts of actin and alpha-actinin. Targeted efficiently to spines via its PDZ domain-mediated interaction with the alpha-actinin/actin cytoskeletal complex. Localizes to synaptosomes in brain (PubMed:15456832). Colocalizes with F-actin. Colocalizes with TRIP6 at cell-cell contacts and lamellipodia. In the cytoplasm, displays a fibrillar pattern with characteristic thick fibers and occasional clusters. Colocalizes with the actin stress fibers. Oxidative stress induces redistribution from cytoskeleton to cytosol. Colocalizes with SRC at the perinuclear region, but not at focal adhesions (By similarity). {ECO:0000250|UniProtKB:P50479, ECO:0000269|PubMed:14729062, ECO:0000269|PubMed:15456832, ECO:0000269|PubMed:22659164}.
uniprot
proteins