TNFAIP1
entrez
7126
canonical
uniprot
Q13829
canonical
ensembl
ENSG00000109079
resolver
ensp
ENSP00000226225
resolver
genesymbol
TNFAIP1
resolver
genesymbol_syn
BACURD2
resolver
genesymbol_syn
EDP1
resolver
hgnc
HGNC:11894
resolver
uniprot
B7Z6M4
resolver
uniprot
Q5TZQ1
resolver
uniprot_entry
BACD2_HUMAN
resolver
uniprot_sec
B7Z6M4
resolver
uniprot_sec
Q5TZQ1
resolver
amino_acid_sequence
MSGDTCLCPASGAKPKLSGFKGGGLGNKYVQLNVGGSLYYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTITLPQNRQEIKELMAEAKYYLIQGLVNMCQSALQDKKDSYQPVCNIPIITSLKEEERLIESSTKPVVKLLYNRSNNKYSYTSNSDDHLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNVLLYETPRVPDNSLLEATSRSRSQASPSEDEETFELRDRVRRIHVKRYSTYDDRQLGHQSTHRD
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. {ECO:0000269|PubMed:19637314, ECO:0000269|PubMed:19782033}.
uniprot
proteins
mass_dalton
36204
uniprot
proteins
mutagenesis
MUTAGEN 71..73; /note="ILI->AAA: Abolishes interaction with CUL3 and induces abnormal actin stress fibers."; /evidence="ECO:0000269|PubMed:19782033"; MUTAGEN 142; /note="S->A: Does not affect phosphorylation level; when associated with A-237."; /evidence="ECO:0000269|PubMed:19851886"; MUTAGEN 237; /note="T->A: Does not affect phosphorylation level; when associated with A-142."; /evidence="ECO:0000269|PubMed:19851886"; MUTAGEN 265; /note="S->A: Does not affect phosphorylation level."; /evidence="ECO:0000269|PubMed:19851886"; MUTAGEN 278; /note="S->A: Slightly impairs phosphorylation level."; /evidence="ECO:0000269|PubMed:19851886"; MUTAGEN 280; /note="S->A: Strongly impairs phosphorylation level."; /evidence="ECO:0000269|PubMed:19851886
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA. {ECO:0000269|PubMed:19851886}.
uniprot
proteins
protein_family
BACURD family
uniprot
proteins
pubmed
1370465
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19637314
uniprot
proteins
pubmed
19782033
uniprot
proteins
pubmed
19851886
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Endosome. Note=Colocalizes with RHOB in endosomes.
uniprot
proteins