LNIR
entrez
81607
canonical
uniprot
Q96NY8
canonical
ensembl
ENSG00000143217
resolver
ensp
ENSP00000356991
resolver
ensp
ENSP00000561689
resolver
genesymbol
LNIR
resolver
genesymbol
NECTIN4
resolver
genesymbol_syn
LNIR
resolver
genesymbol_syn
PRR4
resolver
genesymbol_syn
PVRL4
resolver
hgnc
HGNC:19688
resolver
uniprot
B4DQW3
resolver
uniprot
K4PZ75
resolver
uniprot
Q96K15
resolver
uniprot_entry
K4PZ75_HUMAN
resolver
uniprot_entry
NECT4_HUMAN
resolver
uniprot_sec
B4DQW3
resolver
uniprot_sec
Q96K15
resolver
amino_acid_sequence
MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV
uniprot
proteins
disease_involvement
DISEASE: Ectodermal dysplasia-syndactyly syndrome 1 (EDSS1) [MIM:613573]: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg-shaped and conical crowns. Patients have normal sweating. {ECO:0000269|PubMed:20691405}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.; FUNCTION: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:22048310, ECO:0000269|PubMed:23202587}.
uniprot
proteins
mass_dalton
55454
uniprot
proteins
post_translational_modification
PTM: The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE. {ECO:0000269|PubMed:15784625}.
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
11544254
uniprot
proteins
pubmed
12011057
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15784625
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17474988
uniprot
proteins
pubmed
20691405
uniprot
proteins
pubmed
22048310
uniprot
proteins
pubmed
22902367
uniprot
proteins
pubmed
23202587
uniprot
proteins
sequence_length
510
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000269|PubMed:11544254}. Note=Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).; SUBCELLULAR LOCATION: [Processed poliovirus receptor-related protein 4]: Secreted {ECO:0000269|PubMed:15784625}. Note=The secreted form is found in breast tumor patients (PubMed:15784625).
uniprot
proteins
transmembrane_region
TRANSMEM 350..370; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins