Psmc6
entrez
67089
canonical
uniprot
P62334
canonical
ensembl
ENSMUSG00000021832
resolver
ensp
ENSMUSP00000022380
resolver
enst
ENSMUST00000022380
resolver
genesymbol
Psmc6
resolver
genesymbol_syn
Sug2
resolver
uniprot
P49719
resolver
uniprot
Q14AQ1
resolver
uniprot
Q3TKK1
resolver
uniprot
Q810A6
resolver
uniprot
Q92524
resolver
uniprot
Q9CXH9
resolver
uniprot_entry
PRS10_MOUSE
resolver
uniprot_entry
Q14AQ1_MOUSE
resolver
uniprot_sec
P49719
resolver
uniprot_sec
Q3TKK1
resolver
uniprot_sec
Q810A6
resolver
uniprot_sec
Q92524
resolver
uniprot_sec
Q9CXH9
resolver
amino_acid_sequence
MADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000250|UniProtKB:P62333}.
uniprot
proteins
mass_dalton
44173
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16857966
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
389
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins