ASB6
entrez
140459
canonical
uniprot
Q9NWX5
canonical
ensembl
ENSG00000148331
resolver
ensp
ENSP00000277458
resolver
ensp
ENSP00000277459
resolver
ensp
ENSP00000416172
resolver
enst
ENST00000450050
resolver
genesymbol
ASB6
resolver
hgnc
HGNC:17181
resolver
uniprot
F6TX30
resolver
uniprot
Q5SZB7
resolver
uniprot
Q9BV15
resolver
uniprot_entry
ASB6_HUMAN
resolver
uniprot_entry
F6TX30_HUMAN
resolver
uniprot_sec
Q5SZB7
resolver
uniprot_sec
Q9BV15
resolver
amino_acid_sequence
MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQALHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDDI
uniprot
proteins
function
FUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the regulation of cell proliferation and autophagy by promoting the ubiquitination and degradation of SQSTM1 (PubMed:34164402). {ECO:0000269|PubMed:16325183, ECO:0000269|PubMed:34164402}.
uniprot
proteins
mass_dalton
47136
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by RNF41; leading to proteasomal degradation. {ECO:0000269|PubMed:36446779}.
uniprot
proteins
protein_family
Ankyrin SOCS box (ASB) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16325183
uniprot
proteins
pubmed
34164402
uniprot
proteins
pubmed
36446779
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins