CDC25B
entrez
994
canonical
uniprot
P30305
canonical
ensembl
ENSG00000101224
resolver
ensp
ENSP00000245960
resolver
ensp
ENSP00000339125
resolver
ensp
ENSP00000339170
resolver
ensp
ENSP00000368918
resolver
ensp
ENSP00000405972
resolver
enst
ENST00000344256
resolver
enst
ENST00000379598
resolver
genesymbol
CDC25B
resolver
genesymbol_syn
CDC25HU2
resolver
hgnc
HGNC:1726
resolver
uniprot
B3KS38
resolver
uniprot
B4DIG0
resolver
uniprot
B4DQZ3
resolver
uniprot
B4DRC3
resolver
uniprot
D3DVY1
resolver
uniprot
D3DVY2
resolver
uniprot
D3DVY3
resolver
uniprot
D3DVY4
resolver
uniprot
E1YMX4
resolver
uniprot
E9PCK4
resolver
uniprot
F8W730
resolver
uniprot
G8JLH2
resolver
uniprot
O43551
resolver
uniprot
Q13971
resolver
uniprot
Q5JX77
resolver
uniprot
Q6RSS1
resolver
uniprot
Q9BRA6
resolver
uniprot_entry
B3KS38_HUMAN
resolver
uniprot_entry
B4DIG0_HUMAN
resolver
uniprot_entry
B4DQZ3_HUMAN
resolver
uniprot_entry
B4DRC3_HUMAN
resolver
uniprot_entry
E1YMX4_HUMAN
resolver
uniprot_entry
F8W730_HUMAN
resolver
uniprot_entry
G8JLH2_HUMAN
resolver
uniprot_entry
MPIP2_HUMAN
resolver
uniprot_sec
D3DVY1
resolver
uniprot_sec
D3DVY2
resolver
uniprot_sec
D3DVY3
resolver
uniprot_sec
D3DVY4
resolver
uniprot_sec
E9PCK4
resolver
uniprot_sec
O43551
resolver
uniprot_sec
Q13971
resolver
uniprot_sec
Q5JX77
resolver
uniprot_sec
Q6RSS1
resolver
uniprot_sec
Q9BRA6
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by B-type cyclins. {ECO:0000269|PubMed:1836978}.
uniprot
proteins
amino_acid_sequence
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}.
uniprot
proteins
mass_dalton
64987
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins. {ECO:0000269|PubMed:11333986, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15629715, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:17332740}.
uniprot
proteins
protein_family
MPI phosphatase family
uniprot
proteins
pubmed
10543950
uniprot
proteins
pubmed
11333986
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12400006
uniprot
proteins
pubmed
15128871
uniprot
proteins
pubmed
15150265
uniprot
proteins
pubmed
15311285
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15629715
uniprot
proteins
pubmed
15908796
uniprot
proteins
pubmed
1662986
uniprot
proteins
pubmed
17332740
uniprot
proteins
pubmed
1836978
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20360007
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9188863
uniprot
proteins
sequence_length
580
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15908796}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:15908796}.
uniprot
proteins