PAF1
entrez
54623
canonical
uniprot
Q8N7H5
canonical
ensembl
ENSG00000006712
resolver
ensp
ENSP00000221265
resolver
ensp
ENSP00000468874
resolver
genesymbol
PAF1
resolver
genesymbol_syn
PD2
resolver
hgnc
HGNC:25459
resolver
uniprot
M0QX35
resolver
uniprot
O75239
resolver
uniprot
Q9H166
resolver
uniprot
Q9NUU9
resolver
uniprot_entry
PAF1_HUMAN
resolver
uniprot_sec
M0QX35
resolver
uniprot_sec
O75239
resolver
uniprot_sec
Q9H166
resolver
uniprot_sec
Q9NUU9
resolver
amino_acid_sequence
MAPTIQTQAQREDGHRPNSHRTLPERSGVVCRVKYCNSLPDIPFDPKFITYPFDQNRFVQYKATSLEKQHKHDLLTEPDLGVTIDLINPDTYRIDPNVLLDPADEKLLEEEIQAPTSSKRSQQHAKVVPWMRKTEYISTEFNRYGISNEKPEVKIGVSVKQQFTEEEIYKDRDSQITAIEKTFEDAQKSISQHYSKPRVTPVEVMPVFPDFKMWINPCAQVIFDSDPAPKDTSGAAALEMMSQAMIRGMMDEEGNQFVAYFLPVEETLKKRKRDQEEEMDYAPDDVYDYKIAREYNWNVKNKASKGYEENYFFIFREGDGVYYNELETRVRLSKRRAKAGVQSGTNALLVVKHRDMNEKELEAQEARKAQLENHEPEEEEEEEMETEEKEAGGSDEEQEKGSSSEKEGSEDEHSGSESEREEGDRDEASDKSGSGEDESSEDEARAARDKEEIFGSDADSEDDADSDDEDRGQAQGGSDNDSDSGSNGGGQRSRSHSRSASPFPSGSEHSAQEDGSEAAASDSSEADSDSD
uniprot
proteins
function
FUNCTION: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro. {ECO:0000269|PubMed:16491129, ECO:0000269|PubMed:19410543, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879, ECO:0000269|PubMed:22419161}.
uniprot
proteins
mass_dalton
59976
uniprot
proteins
protein_family
PAF1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15923622
uniprot
proteins
pubmed
16024656
uniprot
proteins
pubmed
16307923
uniprot
proteins
pubmed
16491129
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19410543
uniprot
proteins
pubmed
19952111
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20178742
uniprot
proteins
pubmed
20541477
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21329879
uniprot
proteins
pubmed
22419161
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
30367041
uniprot
proteins
pubmed
30550790
uniprot
proteins
sequence_length
531
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16491129, ECO:0000269|PubMed:30367041}. Note=Punctuate distribution throughout the nucleus except in nucleoli and the perinuclear chromatin.
uniprot
proteins