Cd180
entrez
17079
canonical
uniprot
Q62192
canonical
ensembl
ENSMUSG00000021624
resolver
ensp
ENSMUSP00000022124
resolver
enst
ENSMUST00000022124
resolver
genesymbol
Cd180
resolver
genesymbol_syn
Ly78
resolver
genesymbol_syn
Rp105
resolver
uniprot
Q8C251
resolver
uniprot_entry
CD180_MOUSE
resolver
uniprot_sec
Q8C251
resolver
amino_acid_sequence
MAPDISCFFLVALFLASCRATTSSDQKCIEKEVNKTYNCENLGLNEIPGTLPNSTECLEFSFNVLPTIQNTTFSRLINLTFLDLTRCQIYWIHEDTFQSQHRLDTLVLTANPLIFMAETALSGPKALKHLFFIQTGISSIDFIPLHNQKTLESLYLGSNHISSIKLPKGFPTEKLKVLDFQNNAIHYLSKEDMSSLQQATNLSLNLNGNDIAGIELGAFDSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMDDEDISPAVFEGLCEMSVESINLQKHYFFNISSNTFHCFSGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRLELGTGCLENLENLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIILPSLLPILSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDTEDTLCENPPLLRGVRLSDVTLSCSMAAVGIFFLIVFLLVFAILLIFAVKYFLRWKYQHI
uniprot
proteins
function
FUNCTION: Pattern recognition receptor predominantly expressed on B-cells, dendritic cells, and certain monocytes/macrophages, structurally resembling Toll-like receptors (TLRs) that plays a role in modulating immune responses. While ressembling a TLR, lacks the intracellular TIR (Toll/IL-1R) signaling domain and thus does not directly transduce signals. Instead, modulates immune responses, often in conjunction with other TLRs. For example, in cooperation with MD-1/LY86, interacts directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligand. {ECO:0000250|UniProtKB:Q99467, ECO:0000269|PubMed:10880523}.
uniprot
proteins
mass_dalton
74302
uniprot
proteins
protein_family
Toll-like receptor family
uniprot
proteins
pubmed
10880523
uniprot
proteins
pubmed
15905547
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21959264
uniprot
proteins
pubmed
7897216
uniprot
proteins
pubmed
9686597
uniprot
proteins
sequence_length
661
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 627..650; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins