Asb8
entrez
78541
canonical
uniprot
Q91ZT9
canonical
ensembl
ENSMUSG00000048175
resolver
ensp
ENSMUSP00000057864
resolver
ensp
ENSMUSP00000115813
resolver
ensp
ENSMUSP00000119481
resolver
ensp
ENSMUSP00000121383
resolver
ensp
ENSMUSP00000232677
resolver
ensp
ENSMUSP00000360885
resolver
ensp
ENSMUSP00000360887
resolver
enst
ENSMUST00000059112
resolver
enst
ENSMUST00000123626
resolver
enst
ENSMUST00000123922
resolver
enst
ENSMUST00000143400
resolver
genesymbol
Asb8
resolver
uniprot
A0A0R4J1W1
resolver
uniprot
Q8CDF0
resolver
uniprot
Q8R178
resolver
uniprot
Q9D4Y2
resolver
uniprot_entry
A0A0R4J1W1_MOUSE
resolver
uniprot_entry
ASB8_MOUSE
resolver
uniprot_entry
Q8CDF0_MOUSE
resolver
uniprot_entry
Q9D4Y2_MOUSE
resolver
uniprot_sec
Q8R178
resolver
amino_acid_sequence
MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAERDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLKGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGQFELRKNGIMPREVTKDQQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPVSLKDYLLLLE
uniprot
proteins
function
FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits IFN-beta production through the IRF3 signaling pathway by targeting TBK1 via 'Lys-48'-linked ubiquitination, leading to its proteasomal degradation. {ECO:0000250|UniProtKB:Q9H765}.
uniprot
proteins
mass_dalton
31735
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by TBK1. {ECO:0000250|UniProtKB:Q9H765}.
uniprot
proteins
protein_family
Ankyrin SOCS box (ASB) family
uniprot
proteins
pubmed
11509662
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H765}.
uniprot
proteins