Micall2
entrez
231830
canonical
uniprot
Q3TN34
canonical
ensembl
ENSMUSG00000036718
resolver
ensp
ENSMUSP00000039707
resolver
ensp
ENSMUSP00000127937
resolver
enst
ENSMUST00000044642
resolver
enst
ENSMUST00000170773
resolver
genesymbol
Micall2
resolver
genesymbol_syn
Jrab
resolver
uniprot
E9PZD2
resolver
uniprot
Q3TPY3
resolver
uniprot
Q3UB65
resolver
uniprot_entry
E9PZD2_MOUSE
resolver
uniprot_entry
MILK2_MOUSE
resolver
uniprot_sec
Q3TPY3
resolver
uniprot_sec
Q3UB65
resolver
amino_acid_sequence
MAAIKALQEWCRQQCEGYRDVSITNMTTSFRDGLAFCAILHRHRPDLINFSALRKENIYENNKLAFQVAEEQLGIPALLDAEDMVALKVPDRLSILTYVSQYYNYFHGRSPIGGMAGIKRPSSDSTEELSGKKGLSQPAKLPSPAQTQRSPLSPARTNPVVQRNEGGSQRPSPKAAPGTAGSSVSSICGVCGKHVHLVQRHLADGRLYHRSCFRCKQCSSTLHSGAYRATGEPGVFVCTHHSSEVTSVSPKSSNLASRKPGGVTADTRPFGVSWTVQEANGEGTPLRVRTAAWEHAGGNTTAKGFVQTELKPPSTSQVHVGSSAGPKLPTITVTTTSVTSKALTHVTNSSPIGWSSPAQSSPANFNSRPVVSPSARNTHLPGSQGQTASKGVKTQLNLNSESSNTAVTPAWTSSASKTQQAREKFFQTPPSAPAPASAPAPAPTSKVPTVVTVPTSKVPNVVTAPTSKVPTVVTVPTSKVPTVVSAPTSKVPTVVSAPTSKVPTVVNSTNSRVTTVVNAPTSKVPTVVSATNGRVPTVVTAHTGRVPAVMNTSASKVSPVVDAPAQESSREQALSVLRKALPALTGSGTQAPNRSFPATSSVLVTLPKNEVPQKVPSDKLSALTTQTPNFTIKLEPSAPVNVGNTAVFLQAGKKSPSISPRVGKTSVGSRPQAEVAGVKGPGPISQEGQEEGPEGWRARLKPVDKKTPAGRSLEQKEPVLAEPRIGDTSRKASSSSDSSVHITLTSIQHKRKPCPAGSGPSPAALSPSPSHRKKLAVPPSLDVSADWLQPEPKKQEDGTRSCKEEKSPTRWSRERSAVLDSGLAPPGEAVTSPVRLHPDYIPQEELQRQLQDIESQLDALELRGVELEKRLRAAEGDASEDSLMVDWFRLIHEKQLLLRLESELMYKSKDQRLEEQQLDLQGELRRLMDKPEGLKSPQDRQREQELLSQYVNTVNDRSDIVDFLDEDRLREQEEDQMLENMIQNLGLQRKKSKSFLSKIWSSKSKSGQA
uniprot
proteins
function
FUNCTION: Effector of small Rab GTPases RAB8A and RAB13 which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins (PubMed:16525024, PubMed:18094055, PubMed:20008558, PubMed:23100251, PubMed:23890175). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (PubMed:33976349). {ECO:0000269|PubMed:16525024, ECO:0000269|PubMed:18094055, ECO:0000269|PubMed:20008558, ECO:0000269|PubMed:23100251, ECO:0000269|PubMed:23890175, ECO:0000269|PubMed:33976349}.
uniprot
proteins
mass_dalton
108288
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16525024
uniprot
proteins
pubmed
18094055
uniprot
proteins
pubmed
18332111
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20008558
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23100251
uniprot
proteins
pubmed
23890175
uniprot
proteins
pubmed
33976349
uniprot
proteins
sequence_length
1009
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell junction, tight junction {ECO:0000269|PubMed:18094055, ECO:0000269|PubMed:18332111, ECO:0000269|PubMed:23100251, ECO:0000269|PubMed:23890175}. Recycling endosome {ECO:0000269|PubMed:16525024}. Cell projection, neuron projection {ECO:0000269|PubMed:20008558}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23100251, ECO:0000269|PubMed:23890175}.
uniprot
proteins