Rtel1
entrez
362288
canonical
uniprot
Q5RJZ1
canonical
ensembl
ENSRNOG00000027513
resolver
ensembl
ENSRNOG00055001164
resolver
ensembl
ENSRNOG00060001279
resolver
ensembl
ENSRNOG00065013888
resolver
ensp
ENSRNOP00000088333
resolver
ensp
ENSRNOP00000094899
resolver
enst
ENSRNOT00000100640
resolver
genesymbol
Rtel1
resolver
genesymbol_syn
RTEL1
resolver
uniprot
A0A8I6A605
resolver
uniprot_entry
A0A8I6A605_RAT
resolver
uniprot_entry
RTEL1_RAT
resolver
amino_acid_sequence
MPRVVLNGVTVDFPFQPYPCQQEYMTKVLECLQKKVNGILESPTGTGKTLCLLCTTLAWREHLRDAVSSLKIAERVQGELFASRTLSSWRSAADANGDSIDCYTDIPKIIYASRTHSQLTQVIGELRNTSYRPKVCVLGSREQLCIHPEVKKQESNHMQISLCRKKVASRSCHFYNNVEEKSLEQELATPILDIEDLVKNGSKHKVCPYYLSRNLKQQADIIFMPYNYLLDAKSRKAHNIDLKGTVVIFDEAHNVEKICEESASFDLTPRDVASGLEVINQVLEEQARVAQHGELQQEFIIDTSSSGLNMELEDIAKLKMILLHLEEAIDAVQLPGDDRGVTKPGSYIFELFAEAQITFQTKGCILESLDQIIQHLTGRTGVFTNTAGLQKLMDIIQIVFSVDPLEGSPGSQVGLGSSHFYKVHIHPETSHRRAAQRSDAWSTTASRKQGKVLSYWCFSPSHSMRELVQQGVRTLILTSGTLAPLSSFALEMQIPFPVCLENPHIIDKNQLWVGVIPRGPDGVQLSSAYDKRFSEECLSSLGKALGNIARVVPHGLLVFFPSYPVMEKSLEFWQAQGMSKKVEALKPLFVEPRNKGSFSEVIDAYYQQVASPGSNGATFLAVCRGKASEGLDFSDMNGRGVIVTGLPYPPRMDPRVILKMQFLDEMKGRSRVGGQCLSGQEWYQQQASRAVNQAIGRVIRHRHDYGAIFLCDHRFAYADARAHLPSWVRPYLKVYDNFGRVIRDVAQFFRVAQKAMPLPVPQAVTSSVSEGEAAVKEATLSSHSLSTRKAMSLDVHVPSLRRRPVGLPTAGDSESSVCVEYEQQTFSAQKRPMGLLAALEYNEQKAGASEEQALSSSTPSLRCEKRLSVEQRGGKKKVRLVNHPEEPVAGTQAGRAKMFMVAVKQALSQANFDTFTQALQHYKSSDDFEALVASLTCLFAEDPKKHTLLKGFYQFVRPHHKQQFEDICFQLTGQRCSYQPGNSLPFGEQAQSTASKQGRRELESKLTLSEGADRQLDPGEHLNQGWPHLSTHLTSKGDTSNCPKVGCVGEKPGQPAVNDYLSDVHKALGSASCNQLTAALRAYKQDDDLDKVLAVVAALTTAKPEHLSLLQRFGMFIRRHHKPRFVQTCADLMGLPTIGKGLELPCPRDESTTVPSELTHEDMKPGPSTSKKPEKTQSKISSFLRQRPDQSARSDDTIMQLPPRLPPEHTTSQWNFVCPACATEDTVLFQCPSCDFCRCRACWQRQLQASRLCPACGAVNRKQSIAQVIWPKPQ
uniprot
proteins
ec_number
5.6.2.-
uniprot
proteins
function
FUNCTION: A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. {ECO:0000255|HAMAP-Rule:MF_03065}.
uniprot
proteins
mass_dalton
141779
uniprot
proteins
protein_family
Helicase family
uniprot
proteins
protein_family
RAD3/XPD subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
1274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03065}. Note=Colocalizes with PCNA within the replication foci in S-phase cells. {ECO:0000255|HAMAP-Rule:MF_03065}.
uniprot
proteins