Pou2f2
entrez
18987
canonical
uniprot
Q00196
canonical
ensembl
ENSMUSG00000008496
resolver
ensp
ENSMUSP00000104053
resolver
ensp
ENSMUSP00000104054
resolver
ensp
ENSMUSP00000104055
resolver
ensp
ENSMUSP00000104056
resolver
ensp
ENSMUSP00000135075
resolver
genesymbol
Pou2f2
resolver
genesymbol_syn
Oct2
resolver
genesymbol_syn
Otf2
resolver
uniprot
Q00197
resolver
uniprot
Q00198
resolver
uniprot
Q00199
resolver
uniprot
Q00200
resolver
uniprot
Q00201
resolver
uniprot
Q05882
resolver
uniprot
Q3KR47
resolver
uniprot
Q3U127
resolver
uniprot
Q5XML1
resolver
uniprot
Q5XML2
resolver
uniprot
Q61995
resolver
uniprot
Q61996
resolver
uniprot
Q64245
resolver
uniprot_entry
PO2F2_MOUSE
resolver
uniprot_sec
Q00197
resolver
uniprot_sec
Q00198
resolver
uniprot_sec
Q00199
resolver
uniprot_sec
Q00200
resolver
uniprot_sec
Q00201
resolver
uniprot_sec
Q05882
resolver
uniprot_sec
Q3KR47
resolver
uniprot_sec
Q3U127
resolver
uniprot_sec
Q5XML1
resolver
uniprot_sec
Q5XML2
resolver
uniprot_sec
Q61995
resolver
uniprot_sec
Q61996
resolver
uniprot_sec
Q64245
resolver
activity_regulation
ACTIVITY REGULATION: Transactivation activity is enhanced by transcriptional coactivator POU2AF1. {ECO:0000269|PubMed:23045607}.
uniprot
proteins
amino_acid_sequence
MVHSSMGAPEIRMSKPLEAEKQSLDSPSEHTDTERNGPDINHQNPQNKASPFSVSPTGPSTKIKAEDPSGDSAPAAPPPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPTSYSPHLVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGGGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSAGPGLWWNPAPYQP
uniprot
proteins
function
FUNCTION: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:1281152, PubMed:2011512). Regulates IL6 expression in B cells with POU2AF1 (PubMed:23045607). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000250|UniProtKB:P09086, ECO:0000269|PubMed:1281152, ECO:0000269|PubMed:17285328, ECO:0000269|PubMed:2011512, ECO:0000269|PubMed:23045607, ECO:0000269|PubMed:7935477}.; FUNCTION: [Isoform OCT2.1]: Activates octamer-containing promoters. {ECO:0000269|PubMed:1281152, ECO:0000269|PubMed:2011512}.; FUNCTION: [Isoform OCT2.2]: Activates octamer-containing promoters. {ECO:0000269|PubMed:1281152, ECO:0000269|PubMed:2011512}.; FUNCTION: [Isoform OCT2.3]: Activates octamer-containing promoters. {ECO:0000269|PubMed:1281152, ECO:0000269|PubMed:2011512}.; FUNCTION: [Isoform OCT2.4]: Represses some promoters and activate others. {ECO:0000269|PubMed:1281152, ECO:0000269|PubMed:2011512}.; FUNCTION: [Isoform OCT2.5]: Represses some promoters and activate others (PubMed:1281152, PubMed:2011512). Activates the U2 small nuclear RNA (snRNA) promoter (By similarity). {ECO:0000250|UniProtKB:P09086, ECO:0000269|PubMed:1281152, ECO:0000269|PubMed:2011512}.; FUNCTION: [Isoform OCT2.7]: Unable to bind to the octamer motif, but can still activate the beta-casein gene promoter at low levels. {ECO:0000269|PubMed:17285328}.
uniprot
proteins
mass_dalton
49439
uniprot
proteins
protein_family
Class-2 subfamily
uniprot
proteins
protein_family
POU transcription factor family
uniprot
proteins
pubmed
1281152
uniprot
proteins
pubmed
1425197
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1550677
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17285328
uniprot
proteins
pubmed
1970171
uniprot
proteins
pubmed
1976089
uniprot
proteins
pubmed
2011512
uniprot
proteins
pubmed
23045607
uniprot
proteins
pubmed
7888080
uniprot
proteins
pubmed
7935477
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17285328}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00530, ECO:0000269|PubMed:17285328}. Note=In alveolus epithelial cells of mammary glands, present in the nucleus and cytoplasm. In HC11 mammary epithelial cells, present in the nucleus and preinuclear regions.
uniprot
proteins