Grin2a
entrez
14811
canonical
uniprot
P35436
canonical
ensembl
ENSMUSG00000059003
resolver
ensp
ENSMUSP00000032331
resolver
ensp
ENSMUSP00000111501
resolver
ensp
ENSMUSP00000142900
resolver
enst
ENSMUST00000032331
resolver
enst
ENSMUST00000115835
resolver
enst
ENSMUST00000199708
resolver
genesymbol
Grin2a
resolver
uniprot_entry
NMDE1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: NMDA glutamate receptor activity is inhibited by nM concentrations of Zn(2+). {ECO:0000269|PubMed:1374164}.
uniprot
proteins
amino_acid_sequence
MGRLGYWTLLVLPALLVWHGPAQNAAAEKGTPALNIAVLLGHSHDVTERELRNLWGPEQATGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYRDFISFIKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGLGILTTAASSMLEKFSYIPEAKASCYGQTEKPETPLHTLHQFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENQTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQRGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAKNISNMSNMNSSRMDSPKRAADFIQRGSLIVDMVSDKGNLIYSDNRSFQGKDSIFGENMNELQTFVANRHKDSLSNYVFQGQHPLTLNESNPNTVEVAVSTESKGNSRPRQLWKKSMESLRQDSLNQNPVSQRDEKTAENRTHSLKSPRYLPEEVAHSDISETSSRATCHREPDNNKNHKTKDNFKRSMASKYPKDCSEVERTYVKTKASSPRDKIYTIDGEKEPSFHLDPPQFIENIVLPENVDFPDTYQDHNENFRKGDSTLPMNRNPLHNEDGLPNNDQYKLYAKHFTLKDKGSPHSEGSDRYRQNSTHCRSCLSNLPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNPATREEAYQQDWSQNNALQFQKNKLKINRQHSYDNILDKPREIDLSRPSRSISLKDRERLLEGNLYGSLFSVPSSKLLGNKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHTYGDDQRLVIGRCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHSDVYISEHVMPYAANKNNMYSTPRVLNSCSNRRVYKKMPSIESDV
uniprot
proteins
function
FUNCTION: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:12008020, PubMed:1374164). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (PubMed:7816096, PubMed:8987814). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:12008020, PubMed:1374164, PubMed:7790891). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:10436042, PubMed:12008020). Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (PubMed:25645137). {ECO:0000250|UniProtKB:P35438, ECO:0000269|PubMed:10436042, ECO:0000269|PubMed:12008020, ECO:0000269|PubMed:1374164, ECO:0000269|PubMed:25645137, ECO:0000269|PubMed:7790891, ECO:0000269|PubMed:7816096, ECO:0000269|PubMed:8987814}.
uniprot
proteins
mass_dalton
165421
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
protein_family
NR2A/GRIN2A subfamily
uniprot
proteins
pubmed
10436042
uniprot
proteins
pubmed
12008020
uniprot
proteins
pubmed
1374164
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17329427
uniprot
proteins
pubmed
19243221
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23524343
uniprot
proteins
pubmed
25645137
uniprot
proteins
pubmed
28469074
uniprot
proteins
pubmed
31196628
uniprot
proteins
pubmed
7790891
uniprot
proteins
pubmed
7816096
uniprot
proteins
pubmed
8987814
uniprot
proteins
sequence_length
1464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendritic spine {ECO:0000269|PubMed:28469074}. Cell membrane {ECO:0000269|PubMed:1374164, ECO:0000269|PubMed:28469074}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12879}. Synapse {ECO:0000269|PubMed:28469074}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q00959}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12879}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:28469074}. Note=Expression at the dendrite cell membrane and at synapses is regulated by SORCS2 and the retromer complex. {ECO:0000269|PubMed:28469074}.
uniprot
proteins
transmembrane_region
TRANSMEM 557..576; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q12879"; TRANSMEM 626..646; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q12879"; TRANSMEM 815..835; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q12879
uniprot
proteins