C1s
entrez
192262
canonical
uniprot
Q6P6T1
canonical
ensembl
ENSRNOG00000011971
resolver
ensembl
ENSRNOG00055009808
resolver
ensembl
ENSRNOG00060031999
resolver
ensp
ENSRNOP00000016330
resolver
ensp
ENSRNOP00055013392
resolver
ensp
ENSRNOP00060045927
resolver
enst
ENSRNOT00000016330
resolver
enst
ENSRNOT00055016614
resolver
enst
ENSRNOT00060055483
resolver
genesymbol
C1s
resolver
genesymbol_syn
r-gsp
resolver
uniprot
G3V7L3
resolver
uniprot
O70542
resolver
uniprot
Q8R099
resolver
uniprot_entry
C1S_RAT
resolver
uniprot_entry
G3V7L3_RAT
resolver
uniprot_sec
O70542
resolver
uniprot_sec
Q8R099
resolver
activity_regulation
ACTIVITY REGULATION: Cleaved and activated by C1R. Immunoglobulin-binding promotes autoactivation of C1R, which results in the cleavage of the Arg-Ile bond in the catalytic domain. Inhibited by C1 inhibitor (SERPING1). {ECO:0000250|UniProtKB:P09871}.
uniprot
proteins
amino_acid_sequence
MWCFVFFSLLASFSAEPTMYGEILSPNYPQAYPNEVVKTWDIEVPEGFGIHLYFTHLDMELSENCAYDSVQIISGGIEEERLCGQRTSKSPNSPTVEEFQFPYNRLQVVFTSDFSNEERFTGFAAYYSAVDVNECTDFTDVPCSHFCNNFIGGYFCSCPPEYFLHDDMRTCGVNCSGDVFTALIGEIASPNYPNPYPENSRCEYQIRLQEGFRLVLTIRREDFDVEPADSEGNCHDSLTFAAKNQQFGPYCGNGFPGPLTIKTQSNTLDIVFQTDLTGQNKGWKLRYHGDPIPCPKEISANSIWEPEKAKYVFKDVVKITCVDGFEVVEGNVGSTSFYSTCQSNGQWSNSRLECQPVDCGVPEPIENGKVEDPEDTVFGSVIHYTCEEPYYYMEQEEGGEYHCAANGSWVNDQLGVELPKCIPVCGVPTEPFKVQQRIFGGYSTKIQSFPWQVYFESPRGGGALIDEYWVLTAAHVVEGNSDPVMYVGSTLLKIERLRNAQRLITERVIIHPSWKQEDDLNTRTNFDNDIALVQLKDPVKMGPTVAPICLPETSSDYNPSEGDLGLISGWGRTENRTNVIQLRGAKLPITSLEKCQQVKVENPKARSNDYVFTDNMICAGEKGVDSCEGDSGGAFALPVPNVKDPKFYVAGLVSWGKKCGTYGIYTKVKNYVDWILKTMQENSGPKKD
uniprot
proteins
ec_number
3.4.21.42
uniprot
proteins
function
FUNCTION: Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens. C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains. C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway. {ECO:0000250|UniProtKB:P09871}.; FUNCTION: [Complement C1s subcomponent light chain]: Serine protease component of the complement C1 complex, which catalyzes cleavage and activation of C2 and C4, the next components of the classical complement pathway. Also cleaves IGFBP5 and thereby inhibits the trophic effects of IGF1. {ECO:0000250|UniProtKB:P09871}.
uniprot
proteins
mass_dalton
77071
uniprot
proteins
post_translational_modification
PTM: Cleaved and activated by C1R to generate Complement C1s subcomponent heavy and light chains. {ECO:0000250|UniProtKB:P09871}.; PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. {ECO:0000250|UniProtKB:P09871}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9524231
uniprot
proteins
sequence_length
688
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P09871}. Cell surface {ECO:0000250|UniProtKB:P09871}. Note=Recruited to the surface of pathogens by the C1Q subcomplex. {ECO:0000250|UniProtKB:P09871}.
uniprot
proteins