Fignl2
entrez
668225
canonical
uniprot
J3QK54
canonical
ensembl
ENSMUSG00000095440
resolver
ensp
ENSMUSP00000137256
resolver
ensp
ENSMUSP00000150618
resolver
enst
ENSMUST00000178140
resolver
enst
ENSMUST00000213610
resolver
genesymbol
Fignl2
resolver
uniprot_entry
FIGL2_MOUSE
resolver
amino_acid_sequence
MHWTPEHAQPLNQWPEQHLDVSSTTPSPAHKLELPPGGRQRCHYAWAHDDISALTASNLLKRYAEKYSGVLDYERPGLGSYGDAAFLNGAKGDPEPWPGPEPPYPLASLHEGLPGAKAAGAGGSAGLGGSPVVAGNLTEPLYTGNACGGPSAATEYAAGYGGGYLASGYCAQTSAALAPPPPPALLQPAPPPGYGPSAPLYNYPAAGYAAQPGYGALPPPAAPPAPYLPSGLAAPTPLPAPAPPRPAPYGFPAAAEGVSLKRKAVDEGAEARYRKYAYEPAKAPAADGASYPAADDTECRGNGFRSKPPGATEDGTGKYGGGGPLKVLGSPAYAPQLEPFDKFPERVPAAHGGFAEPSGEPAKGVDPGALELVSSKMVDCGPPVQWADVAGQGALKAALEEELLWPLLRPPACPGSALPPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLAASGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDGASLRAPLLTCLDGSCGARADGVLVVGTTSRPAALDEATRRRFALRFYVALPDGAARGQILQRALAQQGCALNERELAALVQGTQGFSGGELGQLCQQAAAEAGISGLQRPLSYKDVEAALAKVGSRAPSKELDSLVEWDKMYGSGH
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Microtubule-severing enzyme that negatively regulates cell migration and wound healing (PubMed:25756798). In migrating cells, targets dynamic microtubules (MTs) at the leading edge and severs them, thereby suppressing motility (By similarity). Microtubule severing releases ARHGEF2 which activates RHOA, which in turn regulates focal ahesion turnover via focal adhesion kinase, as opposed to F-actin polymerization, to suppress cell motility (By similarity). Negative regulator of axon regeneration that suppresses axonal growth by selectively severing dynamic MTs in the distal axon shaft and growth cone (PubMed:33872220). Contributes to proper cell branching during endothelial and neuronal development (By similarity). {ECO:0000250|UniProtKB:A6NMB9, ECO:0000250|UniProtKB:E9QEA3, ECO:0000269|PubMed:25756798, ECO:0000269|PubMed:33872220}.
uniprot
proteins
mass_dalton
65922
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
15707573
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25756798
uniprot
proteins
pubmed
33872220
uniprot
proteins
sequence_length
644
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15707573}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:A6NMB9}. Note=Localizes at the leading edge of migrating cells. {ECO:0000250|UniProtKB:A6NMB9}.
uniprot
proteins