Fancd2
entrez
312641
canonical
uniprot
Q6IV68
canonical
ensembl
ENSRNOG00000061085
resolver
ensp
ENSRNOP00000077310
resolver
ensp
ENSRNOP00000111154
resolver
enst
ENSRNOT00000113277
resolver
enst
ENSRNOT00000135892
resolver
genesymbol
Fancd2
resolver
uniprot
A0A8I5XW04
resolver
uniprot
A0ABK0LXQ6
resolver
uniprot_entry
A0A8I5XW04_RAT
resolver
uniprot_entry
A0ABK0LXQ6_RAT
resolver
uniprot_entry
FACD2_RAT
resolver
amino_acid_sequence
MVSKRSRLDFEDKETLAEDASKIMKQPLSKLAKKSCGSHEVEENGSVFVRLLKASGLTLKTGDNQNQLGVDQIIFQRKLFQALRKHPSYPKVIEEFVNGLESYTEDIDSLRNCLLSCERLQDEEASMGTFYSKSLIKLLLGIDILQPAIIKMLFEKVPQFLFESESRDGISMPRLIISQLKWLDRIVDSKDLTTQMMQLISVAPVNLQHDFITSLPEILGDSQHANVGKELSELLVQNTSLTVPILDVFSSLRLDPNFLSEIRQLVMGKLSSVRLEDLPVIVKFILHSVTDSTSLEVIAELREKLNVQHFTLPSRIQASQSKLKSKGLASSSGNQENSDKDCIVLLFDVIKSAIRYEKTISEAWIKAIERIQSAAEHKALDVAMLLIIYGTSTQTKKGVERLLRNKIQSDCIQEQLLDSTFSTHCLVLKDICPSILLLAQTLFHSQDQRIILFGSLLCKYAFKFFDTYCQQEVVGALVTHVCSGNEAEVDAALDVLLELIVLNASAMRLNAAFIKGILDYLENMSPQQIRKIFCILSTLAFSQQPGTSNHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAEDRTMPSNSTQRSASVSSEQHTQVTSLLQLVHSCTEHSPWASSLYYDEFANLIQERKLAPKTLEWVAQTIFNDFQDAFVVDFCAVPEGDFPFPVKALYGLEECNTQDGIVINLLPLFFQEFAKDVSQVTSQESSQKSMSPLCLASHFRLLRLCVARQHNGNLDEIDALLDCPLFLPDLEPGEKLESMSAKDRSLMCSLTFLTFNWFREVVNAFCQQTSPEMKGKVLSRLKDLVELQEILEKYLAVIPDYVPPFTSVDLDTLDVIPRSNSAVAAKSRHKGKTGGKKQKADSSTASCTDTLLTEDTSECDVAPSGKSQVDKESTGKEGKTFVSLQNYRAFFRELDIEVFSILHSGLVTKFILDTEMHTEATEVVQLGPAELLFLLEDLSQKLENRLTPSFTKRVCFFKNKGSRNIGFSHLHQRSVQDIVHCVVQLLTPMCNHLENIHNFFQCLGAENLSVNDKARVTAQEHYTMSSCYQKLLQVFHALLAWKGFTHQSNHRLLRSALEVLASRLKQTEEGQPLEELLSQSFSYLQNLQHSIPSFQCGLYLLRLLMALLEKSAVPTQKKEKLASLAKQLLCRAWPHGDKEKNPTFNDHLHDLLCIYLEHTDNVLKAIEEITGVGVPELVNAPKDASSSTFPTLTRHTFVIFFRVMMAELEKTVKGLQAGTATDSQQVHEEKLLYWNMAVRDFSILINLMKVFDSYPVLHVCLKYGRRFVEAFLKQCMPLLDFSFRKHRDDVLSLLQTLQLNTRLLHHLCGHSKIHQDTRLTKHVPLLKKSLELLVCRVKAMLVLNNCREAFWLGTLKNRDLQGEEIISQHPSSPENTSEDSEDGMTSYVSRNRAIEDGEDEANDGQDRDSDESDDSSS
uniprot
proteins
function
FUNCTION: Required for maintenance of chromosomal stability (By similarity). Promotes accurate and efficient pairing of homologs during meiosis (By similarity). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (By similarity). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (By similarity). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin (By similarity). May also be involved in B-cell immunoglobulin isotype switching (By similarity). {ECO:0000250|UniProtKB:Q68Y81, ECO:0000250|UniProtKB:Q9BXW9}.
uniprot
proteins
mass_dalton
163621
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated on Lys-561 during S phase and upon genotoxic stress by FANCL in complex with E2 ligases UBE2T or UBE2W (By similarity). Deubiquitinated by USP1 as cells enter G2/M, or once DNA repair is completed (By similarity). Monoubiquitination requires the joint intervention of the FANC core complex, including FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, and FANCM, and proteins involved in cell cycle checkpoints and DNA repair, including RPA1, ATR, CHEK1 and BRCA1, and is mediated by FANCL/PHF9 (By similarity). Monoubiquitination prevents DNA release from the FANCI-FANCD2 complex (By similarity). FANCD2 is only ubiquitinated in the FANCI-FANCD2 complex and the monoubiquitination of FANCD2 is promoted by phosphorylation of FANCI (By similarity). Ubiquitination is required for binding to chromatin, interaction with BRCA1, BRCA2 and MTMR15/FAN1, DNA repair, and normal cell cycle progression (By similarity). {ECO:0000250|UniProtKB:Q68Y81, ECO:0000250|UniProtKB:Q9BXW9}.; PTM: Phosphorylated on several sites including Ser-222 and Ser-1401 in response to genotoxic stress by ATM and/or ATR. {ECO:0000250|UniProtKB:Q9BXW9}.
uniprot
proteins
protein_family
Fanconi anemia protein FANCD2 family
uniprot
proteins
sequence_length
1451
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BXW9}. Note=Concentrates in nuclear foci during S phase and upon genotoxic stress. {ECO:0000250|UniProtKB:Q9BXW9}.
uniprot
proteins