Tspan17
entrez
74257
canonical
uniprot
Q9D7W4
canonical
ensembl
ENSMUSG00000025875
resolver
ensp
ENSMUSP00000026993
resolver
ensp
ENSMUSP00000131671
resolver
ensp
ENSMUSP00000294836
resolver
ensp
ENSMUSP00000294840
resolver
ensp
ENSMUSP00000294842
resolver
ensp
ENSMUSP00000294844
resolver
enst
ENSMUST00000026993
resolver
genesymbol
Tspan17
resolver
genesymbol_syn
Fbxo23
resolver
genesymbol_syn
Tm4sf17
resolver
uniprot
F7C2B8
resolver
uniprot
Q3TAQ3
resolver
uniprot
Q91VI6
resolver
uniprot_entry
F7C2B8_MOUSE
resolver
uniprot_entry
Q3TAQ3_MOUSE
resolver
uniprot_entry
TSN17_MOUSE
resolver
uniprot_sec
Q91VI6
resolver
amino_acid_sequence
MPGKHQQFQDPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWGEKGVLSNISALTDLGGLDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELAAGILAFVFKDWIRDQLNLFINNNVKAYRDDLDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDIRLKLELEQEGSIYTKGCVGQFEKWLQDNLIVVAGVLVGIALLQIFGLCLAQNLVSDIKAVKANW
uniprot
proteins
function
FUNCTION: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:23035126, PubMed:26668317). Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration (By similarity). {ECO:0000250|UniProtKB:Q96FV3, ECO:0000269|PubMed:23035126, ECO:0000269|PubMed:26668317}.
uniprot
proteins
mass_dalton
30126
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23035126
uniprot
proteins
pubmed
26668317
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:26668317}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 64..84; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 95..115; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 235..255; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins