Ghrl
entrez
59301
canonical
uniprot
Q9QYH7
canonical
ensembl
ENSRNOG00055007999
resolver
ensembl
ENSRNOG00060012756
resolver
genesymbol
Ghrl
resolver
uniprot
Q9ET69
resolver
uniprot_entry
GHRL_RAT
resolver
uniprot_sec
Q9ET69
resolver
amino_acid_sequence
MVSSATICSLLLLSMLWMDMAMAGSSFLSPEHQKAQQRKESKKPPAKLQPRALEGWLHPEDRGQAEEAEEELEIRFNAPFDVGIKLSGAQYQQHGRALGKFLQDILWEEVKEAPANK
uniprot
proteins
function
FUNCTION: Precursor of the appetite-regulating peptide ghrelin, including ghrelin-27 and ghrelin-28. {ECO:0000250|UniProtKB:Q9UBU3}.; FUNCTION: [Ghrelin-27]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (By similarity). Induces the release of growth hormone from the pituitary (By similarity). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion (PubMed:11196643). Involved in growth regulation (By similarity). {ECO:0000250|UniProtKB:Q9UBU3, ECO:0000269|PubMed:11196643}.; FUNCTION: [Ghrelin-28]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (By similarity). Octanoylated ghrelin-28 is the most commonly found ghrelin and octanoylation is essential for the activation of the growth hormone secretagogue receptor type 1 (GHSR) (By similarity). Induces the release of growth hormone from the pituitary (By similarity). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion (PubMed:11196643). Involved in growth regulation (By similarity). {ECO:0000250|UniProtKB:Q9UBU3, ECO:0000269|PubMed:11196643}.; FUNCTION: [Obestatin-23]: May have an appetite-reducing effect resulting in decreased food intake (PubMed:16284174). May reduce gastric emptying activity and jejunal motility (PubMed:16284174). {ECO:0000269|PubMed:16284174}.
uniprot
proteins
mass_dalton
13176
uniprot
proteins
post_translational_modification
PTM: O-octanoylated by GOAT/MBOAT4 (By similarity). O-octanoylation or O-decanoylation is essential for ghrelin activity (By similarity). The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26 (By similarity). A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid (By similarity). Also O-acetylated and O-butyrylated on Ser-26 to minor levels (By similarity). {ECO:0000250|UniProtKB:Q9EQX0}.; PTM: Amidation of Leu-98 is essential for obestatin activity. {ECO:0000269|PubMed:16284174}.; PTM: O-octanoylated by GOAT/MBOAT4. O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid. Also O-acetylated and O-butyrylated on Ser-26 to minor levels. {ECO:0000250|UniProtKB:Q9UBU3}.
uniprot
proteins
protein_family
Motilin family
uniprot
proteins
pubmed
10604470
uniprot
proteins
pubmed
10801861
uniprot
proteins
pubmed
11162448
uniprot
proteins
pubmed
11196643
uniprot
proteins
pubmed
11306336
uniprot
proteins
pubmed
11549267
uniprot
proteins
pubmed
16284174
uniprot
proteins
pubmed
17289961
uniprot
proteins
sequence_length
117
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9EQX0}.
uniprot
proteins