HDGF
entrez
3068
canonical
uniprot
P51858
canonical
ensembl
ENSG00000143321
resolver
ensp
ENSP00000349878
resolver
ensp
ENSP00000357189
resolver
ensp
ENSP00000357192
resolver
genesymbol
HDGF
resolver
genesymbol_syn
HMG1L2
resolver
hgnc
HGNC:4856
resolver
uniprot
A0A384NPW1
resolver
uniprot
A8K8G0
resolver
uniprot
B3KU21
resolver
uniprot
B7Z958
resolver
uniprot
D3DVC9
resolver
uniprot
Q5SZ07
resolver
uniprot
Q5SZ08
resolver
uniprot
Q5SZ09
resolver
uniprot_entry
A0A384NPW1_HUMAN
resolver
uniprot_entry
A8K8G0_HUMAN
resolver
uniprot_entry
B7Z958_HUMAN
resolver
uniprot_entry
HDGF_HUMAN
resolver
uniprot_sec
B3KU21
resolver
uniprot_sec
D3DVC9
resolver
uniprot_sec
Q5SZ07
resolver
uniprot_sec
Q5SZ08
resolver
uniprot_sec
Q5SZ09
resolver
amino_acid_sequence
MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCVEEPEPEPEAAEGDGDKKGNAEGSSDEEGKLVIDEPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEEKEAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEEEEEDEEEEATKEDAEAPGIRDHESL
uniprot
proteins
function
FUNCTION: [Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). {ECO:0000269|PubMed:11751870, ECO:0000269|PubMed:15491618, ECO:0000269|PubMed:17974029, ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 2]: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719). {ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 3]: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719). {ECO:0000269|PubMed:26845719}.
uniprot
proteins
mass_dalton
26788
uniprot
proteins
mutagenesis
MUTAGEN 165; /note="S->A: Abolishes secretion and alters location of the protein from inside the exosome to the exosomal surface."; /evidence="ECO:0000269|PubMed:27926477
uniprot
proteins
post_translational_modification
PTM: Sumoylated with SUMO1. Sumoylation prevents binding to chromatin. {ECO:0000269|PubMed:18331345}.; PTM: Phosphorylation at Ser-165 is likely to be required for secretion. {ECO:0000250|UniProtKB:P51859}.
uniprot
proteins
protein_family
HDGF family
uniprot
proteins
pubmed
11751870
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15302935
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15491618
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16807684
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17270212
uniprot
proteins
pubmed
17487921
uniprot
proteins
pubmed
17974029
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18331345
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
26845719
uniprot
proteins
pubmed
27926477
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
7929202
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:11751870, ECO:0000269|PubMed:26845719}. Cytoplasm {ECO:0000269|PubMed:11751870}. Secreted, extracellular exosome {ECO:0000269|PubMed:27926477}. Note=Secreted by exosomes and is located inside the exosome (PubMed:27926477). May also be secreted as free protein via an as yet unknown pathway (PubMed:27926477). {ECO:0000269|PubMed:27926477}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:26845719}. Cytoplasm {ECO:0000269|PubMed:26845719}. Secreted, extracellular exosome {ECO:0000269|PubMed:27926477}. Note=Secreted by exosomes and is located on the outer exosome surface. {ECO:0000269|PubMed:27926477}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:26845719}. Cytoplasm {ECO:0000269|PubMed:26845719}. Secreted, extracellular exosome {ECO:0000269|PubMed:27926477}. Note=Secreted by exosomes and is located on the outer exosome surface. {ECO:0000269|PubMed:27926477}.
uniprot
proteins