Glrx2
entrez
114022
canonical
uniprot
Q6AXW1
canonical
ensembl
ENSRNOG00000003385
resolver
ensembl
ENSRNOG00055000771
resolver
ensembl
ENSRNOG00060005408
resolver
ensembl
ENSRNOG00065005766
resolver
ensp
ENSRNOP00000056811
resolver
ensp
ENSRNOP00000096477
resolver
genesymbol
Glrx2
resolver
genesymbol_syn
Grx2
resolver
uniprot_entry
GLRX2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: The 2Fe-2S present in the homodimer leads to inactivation of the enzyme. The 2Fe-2S may serve as a redox sensor: the presence of one-electron oxidants or reductants leading to the loss of the 2Fe-2S cluster, subsequent monomerization and activation of the enzyme (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MSWYRAASVGRRLVASGRILAGRRGAAGAAGSGMGNSTSSFWGKSATTPVNQIQETISNNCVVIFSKSSCSYCSMAKKIFHDMNVNYKVVELDMVEYGSQFQEALYKMTGERTVPRIFVNGIFIGGAADTHRLHKEGKLLPLVHQCYLNKSKRKDVE
uniprot
proteins
function
FUNCTION: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
17275
uniprot
proteins
protein_family
Glutaredoxin family
uniprot
proteins
pubmed
11397793
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
157
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000250}.
uniprot
proteins