Slc9a5
entrez
192215
canonical
uniprot
Q9Z0X2
canonical
ensembl
ENSRNOG00000028844
resolver
ensembl
ENSRNOG00055018484
resolver
ensembl
ENSRNOG00060012503
resolver
ensembl
ENSRNOG00065012173
resolver
ensp
ENSRNOP00000063061
resolver
ensp
ENSRNOP00055025374
resolver
ensp
ENSRNOP00060016709
resolver
ensp
ENSRNOP00065015147
resolver
enst
ENSRNOT00000068299
resolver
enst
ENSRNOT00055031420
resolver
enst
ENSRNOT00060021182
resolver
enst
ENSRNOT00065019773
resolver
genesymbol
Slc9a5
resolver
genesymbol_syn
Nhe5
resolver
uniprot
G3V9Y4
resolver
uniprot_entry
SL9A5_RAT
resolver
uniprot_sec
G3V9Y4
resolver
amino_acid_sequence
MLRVALLLLPGLPLAGVGATEEPTQEPGPLGEPPGLALFRWQWHEVEAPYLVALWILVASLAKIVFHLSRKVTSLVPESCLLILLGLALGGIVLAVAKKAEYQLEPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGVALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTAVKYTMKTLASSAETVIFMLLGISAVDSSKWAWDSGLVLGTLFFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLRVKRSDYHKPTLNQELHEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMRRSAYRIRDQIWDVYYRLNIRDAISFVDQGGHVLSSAGLTLPSMPSRNSVAETSVTNLLRESGSGACLDLQVIDTVRSGRDREDAVMHHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVFQQNMKRRLESFKSTKHNICFTKSKPRPRKTGHKKKDGVANPEATNGKPPRDLGFQDTAAVILTVESEEEEESESSETEKEDDEGIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKELPWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSISSLESLASPPCTQPPTLTRLPPHPLVPEEPQVPLDLSSDPRSSFAFPPSLAKAGRSRSESSADIPQQQELQPLMGHKDHTHLSPGPANSHWCIQFNRGGRL
uniprot
proteins
function
FUNCTION: Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Responsible for regulating intracellular pH homeostasis, in particular in neural tissues (PubMed:9933642). Acts as a negative regulator of dendritic spine growth. Plays a role in postsynaptic remodeling and signaling. Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking (By similarity). {ECO:0000250|UniProtKB:Q14940, ECO:0000269|PubMed:9933642}.
uniprot
proteins
mass_dalton
99108
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKAA2; promotes its accumulation at the cell surface. Phosphorylated by CSNK2A1 in a manner favoring its beta-arrestin binding and endocytosis. {ECO:0000250|UniProtKB:Q14940}.
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
12576672
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
9933642
uniprot
proteins
sequence_length
898
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q14940}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q14940}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:Q14940}; Multi-pass membrane protein {ECO:0000255}. Synaptic cell membrane {ECO:0000250|UniProtKB:Q14940}; Multi-pass membrane protein. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q14940}. Note=Cycles between recycling endosome and plasma membrane in response to diverse stimuli. Its internalization is clathrin- and beta-arrestin dependent and its plasma membrane insertion from the recycling endosomes requires phosphoinositide 3-kinase (PIK3CA) and SCAMP2. {ECO:0000250|UniProtKB:Q14940}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 48..68; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 76..96; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 137..157; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 176..196; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 249..269; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 279..299; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 334..354; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 363..383; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 401..421; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 431..451; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins