Pde6h
entrez
78600
canonical
uniprot
P61249
canonical
ensembl
ENSMUSG00000064330
resolver
ensp
ENSMUSP00000119246
resolver
enst
ENSMUST00000137768
resolver
genesymbol
Pde6h
resolver
uniprot
Q14BP9
resolver
uniprot
Q9D1Y6
resolver
uniprot
Q9EP63
resolver
uniprot_entry
CNCG_MOUSE
resolver
uniprot_sec
Q14BP9
resolver
uniprot_sec
Q9D1Y6
resolver
uniprot_sec
Q9EP63
resolver
amino_acid_sequence
MSDSPSLSPPAPSQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIPGMEGLGTDITVICPWEAFSHLELHELAQFGII
uniprot
proteins
function
FUNCTION: Inhibitory gamma subunit of the cone-specific cGMP phosphodiesterase (PDE6) complex which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade (By similarity). The PDE6 holoenzyme consists of two catalytic alpha subunits (PDE6C) and two inhibitory gamma subunits (PDE6H) (PubMed:39739818). Light-activated GNAT2 relieves gamma subunit-mediated inhibition, allowing the catalytic subunits to hydrolyze cGMP and mediate visual signal transduction and amplification. The resulting decrease in cytosolic cGMP levels triggers the closure of cGMP-gated cation channels at the plasma membrane, leading to hyperpolarization of cone photoreceptors (By similarity). Inhibition by the gamma subunit is relatively dynamic and less tightly coupled than in rods, allowing transient access to the catalytic pocket and facilitating the rapid phototransduction kinetics characteristic of cones (PubMed:39739818). {ECO:0000250|UniProtKB:P22571, ECO:0000250|UniProtKB:P51160, ECO:0000269|PubMed:39739818}.
uniprot
proteins
mass_dalton
9028
uniprot
proteins
protein_family
Rod/cone cGMP-PDE gamma subunit family
uniprot
proteins
pubmed
11944991
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
37384398
uniprot
proteins
pubmed
39739818
uniprot
proteins
sequence_length
83
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000269|PubMed:37384398}. Note=Localized in cone outer segment disk membranes. {ECO:0000269|PubMed:37384398}.
uniprot
proteins