Tpx2
entrez
72119
canonical
uniprot
A2APB8
canonical
ensembl
ENSMUSG00000027469
resolver
ensp
ENSMUSP00000028969
resolver
ensp
ENSMUSP00000105441
resolver
ensp
ENSMUSP00000128888
resolver
ensp
ENSMUSP00000136457
resolver
ensp
ENSMUSP00000258157
resolver
ensp
ENSMUSP00000258158
resolver
ensp
ENSMUSP00000258159
resolver
ensp
ENSMUSP00000258162
resolver
enst
ENSMUST00000028969
resolver
enst
ENSMUST00000109816
resolver
enst
ENSMUST00000164120
resolver
enst
ENSMUST00000178997
resolver
genesymbol
Tpx2
resolver
uniprot
Q3U500
resolver
uniprot
Q6P9S6
resolver
uniprot
Q8BTJ3
resolver
uniprot_entry
Q8BTJ3_MOUSE
resolver
uniprot_entry
TPX2_MOUSE
resolver
uniprot_sec
Q3U500
resolver
uniprot_sec
Q6P9S6
resolver
amino_acid_sequence
MSQVPTTYSFDAPTDFINFSSLDAEEDTENIDSWFDEKANLENKFLRQRGIGEPFQGKNSLRKAKLQQGFVTPLKAVDNTYHKETEKENLQKQSIPSNDCSSLDAKRAVSGNTPVQPQRRSIRLSAQKDLEQKEKNHVASVEMKAKRCVAPATDCPPQKRMKVSHKKKLEEEEEGSAPATSRKNERETLEKAKGKHTVPGVPPAREKVLKSTEEQEIEKRLRMQQEVVELRRKNEEFKKLALAGPGQPVKKSTSQVTKTVDFHFLTDERIKQHPKNQEEYKEVNFMSELRKHSSTPARGTRGCTIIKPFNLSKGKKRTFDEAASTYVPIAQQVEAFHKRTPNRYHLRNKKDESLLPSKSVNKIARDPQTPILQTKYRTRAVTCKSTAEQEAEELEKLQQYKFKARELDPRIFESGPILPKRAPVKPPTQPVGFDLEIEKRIHERESKKKTEDEQFEFHSRPCPTKILEDVVGVPEKKVIPATVPKSPVFALKNRIRVPIKDEEEEKPVVIKAQPVPHYGVPYKPHIAEARNVEVCPFSFDTRDKERQLQKEKKIKEMQKGEVPKFKALPVPHFDTINLPEKKVKNVTQAEPFSLETDKRGAYKAEMWKHQLEEEQKQQKDAACFKARPNTVIFQEPFVPKKEKKSLAENPSGSLVQEPFQLATERRAKERQELEKKMAEVEAWKLQQLEEVRQQEEEQQKEELARLRKELVHKANPIRKYAAVEVKSSELPLTVPVSPKFSTRFQ
uniprot
proteins
function
FUNCTION: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation. {ECO:0000250|UniProtKB:Q9ULW0, ECO:0000269|PubMed:18663142}.
uniprot
proteins
mass_dalton
85894
uniprot
proteins
mutagenesis
MUTAGEN 8..11; /note="YSFD->ASAA: Abolishes interaction with AURKA."; /evidence="ECO:0000269|PubMed:18663142
uniprot
proteins
protein_family
TPX2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18663142
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
27753540
uniprot
proteins
sequence_length
745
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9ULW0}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:27753540}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9ULW0}. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. {ECO:0000250|UniProtKB:Q9ULW0}.
uniprot
proteins