Atox1
entrez
84355
canonical
uniprot
Q9WUC4
canonical
ensembl
ENSRNOG00000013118
resolver
ensp
ENSRNOP00000017588
resolver
enst
ENSRNOT00000017588
resolver
genesymbol
Atox1
resolver
genesymbol_syn
Rah1
resolver
uniprot
Q549B3
resolver
uniprot_entry
ATOX1_RAT
resolver
uniprot_sec
Q549B3
resolver
amino_acid_sequence
MPKHEFSVDMTCGGCAEAVSRVLNKLGGVEFNIDLPNKKVCIESEHSSDILLATLNKTGKAVSYLGPK
uniprot
proteins
function
FUNCTION: Multifunctional copper-sensing protein that operates both as a cytosolic copper chaperone and as a copper-dependent transcription factor. Essential for maintaining cellular copper homeostasis and linking copper distribution to redox balance, signal transduction, and gene regulation. In the cytosol, transfers copper to the copper-transporting ATPase ATP7A at the trans-Golgi network, which is required for activation of secretory copper enzymes including lysyl oxidase (LOX) and SOD3. This chaperone function is essential for full SOD3 and LOX enzymatic activity. Acts as a copper-dependent transcription factor. Upon copper binding, translocates to the nucleus where it binds specific promoter elements and regulates transcription of genes involved in cell proliferation, oxidative stress defense, and extracellular matrix remodeling. Activates expression of target genes including CCND1, SOD3 and NCF1, thereby linking cellular copper status to gene expression programs controlling growth and redox homeostasis. {ECO:0000250|UniProtKB:O08997}.
uniprot
proteins
mass_dalton
7292
uniprot
proteins
protein_family
ATX1 family
uniprot
proteins
pubmed
10473283
uniprot
proteins
pubmed
10558899
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
68
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O08997}. Nucleus {ECO:0000250|UniProtKB:O08997}. Note=Primarily cytoplasmic; translocates to the nucleus in a copper- and stimulus-dependent manner. {ECO:0000250|UniProtKB:O08997}.
uniprot
proteins