PAK5
entrez
57144
canonical
uniprot
Q9P286
canonical
ensembl
ENSG00000101349
resolver
ensp
ENSP00000322957
resolver
ensp
ENSP00000367679
resolver
ensp
ENSP00000367686
resolver
enst
ENST00000353224
resolver
enst
ENST00000378423
resolver
enst
ENST00000378429
resolver
genesymbol
PAK5
resolver
genesymbol_syn
KIAA1264
resolver
genesymbol_syn
PAK7
resolver
hgnc
HGNC:15916
resolver
uniprot
A8K5T6
resolver
uniprot
B0AZM9
resolver
uniprot
D3DW14
resolver
uniprot
Q5W115
resolver
uniprot
Q8TB93
resolver
uniprot
Q9BX09
resolver
uniprot
Q9ULF6
resolver
uniprot_entry
B0AZM9_HUMAN
resolver
uniprot_entry
PAK5_HUMAN
resolver
uniprot_sec
A8K5T6
resolver
uniprot_sec
D3DW14
resolver
uniprot_sec
Q5W115
resolver
uniprot_sec
Q8TB93
resolver
uniprot_sec
Q9BX09
resolver
uniprot_sec
Q9ULF6
resolver
amino_acid_sequence
MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCITPIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHAEENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEAYYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTAGTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQSQSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. {ECO:0000269|PubMed:12897128, ECO:0000269|PubMed:16014608, ECO:0000269|PubMed:16581795, ECO:0000269|PubMed:18465753, ECO:0000269|PubMed:20564219}.
uniprot
proteins
mass_dalton
80745
uniprot
proteins
mutagenesis
MUTAGEN 19..22; /note="HRVH->LRVL: Complete loss of CDC42 binding and CDC42-mediated autophosphorylation."; /evidence="ECO:0000269|PubMed:12860998
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated when activated by CDC42/p21.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12032833
uniprot
proteins
pubmed
12860998
uniprot
proteins
pubmed
12897128
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16014608
uniprot
proteins
pubmed
16581795
uniprot
proteins
pubmed
17064668
uniprot
proteins
pubmed
17292838
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18465753
uniprot
proteins
pubmed
20564219
uniprot
proteins
sequence_length
719
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion. Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
uniprot
proteins