Pitx3
entrez
29609
canonical
uniprot
P81062
canonical
ensembl
ENSRNOG00000019194
resolver
ensembl
ENSRNOG00055004453
resolver
ensembl
ENSRNOG00060028719
resolver
ensembl
ENSRNOG00065029992
resolver
ensp
ENSRNOP00000026013
resolver
ensp
ENSRNOP00055005284
resolver
ensp
ENSRNOP00060041622
resolver
ensp
ENSRNOP00065042642
resolver
enst
ENSRNOT00000026013
resolver
enst
ENSRNOT00055007054
resolver
enst
ENSRNOT00060049919
resolver
enst
ENSRNOT00065051808
resolver
genesymbol
Pitx3
resolver
genesymbol_syn
Ptx3
resolver
uniprot_entry
PITX3_RAT
resolver
amino_acid_sequence
MEFGLLGEAEARSPALSLSDAGTPHPPLPEHGCKGQEHSDSEKASASLPGGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERSQQAELCKGGFAAPLGGLVPPYEEVYPGYTYGNWPPKALAPPLAAKTFPFAFNSVNVGPLASQPVFSPPSSIAASMVPSAAAAPGTVPGPGALQGLGGAPPGLAPAAVSSGAVSCPYASAAAAAAAAASSPYVYRDPCNSSLASLRLKAKQHASFSYPAVPGPPPAANLSPCQYAVERPV
uniprot
proteins
function
FUNCTION: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
31729
uniprot
proteins
protein_family
Bicoid subfamily
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
18951485
uniprot
proteins
pubmed
9371841
uniprot
proteins
sequence_length
302
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins