PTPRD
entrez
5789
canonical
uniprot
P23468
canonical
ensembl
ENSG00000153707
resolver
ensp
ENSP00000347373
resolver
ensp
ENSP00000370593
resolver
ensp
ENSP00000380731
resolver
ensp
ENSP00000380735
resolver
ensp
ENSP00000417093
resolver
ensp
ENSP00000440515
resolver
ensp
ENSP00000525772
resolver
enst
ENST00000537002
resolver
genesymbol
PTPRD
resolver
hgnc
HGNC:9668
resolver
uniprot
A0ACM8Q8T2
resolver
uniprot
B1ALA0
resolver
uniprot
F5GWT7
resolver
uniprot
F5GWY7
resolver
uniprot
Q2HXI4
resolver
uniprot
Q3KPI9
resolver
uniprot
Q3KPJ0
resolver
uniprot
Q3KPJ1
resolver
uniprot
Q3KPJ2
resolver
uniprot
Q59H90
resolver
uniprot_entry
A0ACM8Q8T2_HUMAN
resolver
uniprot_entry
PTPRD_HUMAN
resolver
uniprot_entry
Q2HXI4_HUMAN
resolver
uniprot_entry
Q3KPI9_HUMAN
resolver
uniprot_entry
Q59H90_HUMAN
resolver
uniprot_sec
B1ALA0
resolver
uniprot_sec
F5GWT7
resolver
uniprot_sec
F5GWY7
resolver
uniprot_sec
Q3KPJ0
resolver
uniprot_sec
Q3KPJ1
resolver
uniprot_sec
Q3KPJ2
resolver
amino_acid_sequence
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. {ECO:0000250|UniProtKB:Q64487}.
uniprot
proteins
mass_dalton
214760
uniprot
proteins
mutagenesis
MUTAGEN 1178; /note="R->A: 2.5-fold reduction in cleavage. 10-fold reduction in cleavage; when associated with A-1181."; /evidence="ECO:0000269|PubMed:7896816"; MUTAGEN 1181; /note="R->A: No reduction in cleavage. 10-fold reduction in cleavage; when associated with A-1178."; /evidence="ECO:0000269|PubMed:7896816
uniprot
proteins
post_translational_modification
PTM: A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization. {ECO:0000269|PubMed:7896816}.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 2A subfamily
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
2170109
uniprot
proteins
pubmed
7896816
uniprot
proteins
pubmed
9624153
uniprot
proteins
sequence_length
1912
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 1266..1290; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins