Tcf15
entrez
21407
canonical
uniprot
Q60756
canonical
ensembl
ENSMUSG00000068079
resolver
ensp
ENSMUSP00000086511
resolver
enst
ENSMUST00000089112
resolver
genesymbol
Tcf15
resolver
genesymbol_syn
Bhlhec2
resolver
uniprot
Q60788
resolver
uniprot_entry
TCF15_MOUSE
resolver
uniprot_sec
Q60788
resolver
amino_acid_sequence
MAFALLRPVGAHVLYPDVRLLSEDEENRSESDASDQSFGCCEGLEAARRGPGPGSGRRASNGAGPVVVVRQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSYIAHLANVLLLGDAADDGQPCFRAAGGGKSAVPAADGRQPRSICTFCLSNQRKGGSRRDLGGSCLKVRGVAPLRGPRR
uniprot
proteins
function
FUNCTION: Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency (PubMed:23395635, PubMed:24038871, PubMed:32669716, PubMed:7597044, PubMed:8955271). Essential for the mesenchymal to epithelial transition associated with somite formation (PubMed:24038871, PubMed:7597044, PubMed:8955271). Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles (PubMed:8955271). Required for proper localization of somite epithelium markers during the mesenchymal to epithelial transition (PubMed:24038871). Also plays a key role in regulation of stem cell pluripotency (PubMed:23395635, PubMed:32669716). Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation (PubMed:23395635). Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long-term self-renewal (PubMed:32669716). Together with MEOX2, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (PubMed:25561514). Acts by forming a heterodimer with another helix-loop-helix (bHLH) protein, such as TCF3/E12, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes (PubMed:15226298, PubMed:23395635). {ECO:0000269|PubMed:15226298, ECO:0000269|PubMed:23395635, ECO:0000269|PubMed:24038871, ECO:0000269|PubMed:25561514, ECO:0000269|PubMed:32669716, ECO:0000269|PubMed:7597044, ECO:0000269|PubMed:8955271}.
uniprot
proteins
mass_dalton
20721
uniprot
proteins
mutagenesis
MUTAGEN 70..71; /note="RQ->KK: Does not affect formation of a heterodimer with TCF3 and ability to bind DNA."; /evidence="ECO:0000269|PubMed:15226298"; MUTAGEN 75; /note="A->N: Does not affect formation of a heterodimer with TCF3 and ability to bind DNA."; /evidence="ECO:0000269|PubMed:15226298"; MUTAGEN 90; /note="F->P: Impaired formation of a heterodimer with TCF3 and decreased ability to bind DNA."; /evidence="ECO:0000269|PubMed:15226298
uniprot
proteins
pubmed
15226298
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23395635
uniprot
proteins
pubmed
24038871
uniprot
proteins
pubmed
25561514
uniprot
proteins
pubmed
32669716
uniprot
proteins
pubmed
7597044
uniprot
proteins
pubmed
7729571
uniprot
proteins
pubmed
8041747
uniprot
proteins
pubmed
8825648
uniprot
proteins
pubmed
8955271
uniprot
proteins
sequence_length
195
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:23395635}.
uniprot
proteins