Akirin2
entrez
433693
canonical
uniprot
B1AXD8
canonical
ensembl
ENSMUSG00000028291
resolver
ensp
ENSMUSP00000081322
resolver
enst
ENSMUST00000084299
resolver
genesymbol
Akirin2
resolver
uniprot
Q641L8
resolver
uniprot
Q9DAH4
resolver
uniprot_entry
AKIR2_MOUSE
resolver
uniprot_sec
Q641L8
resolver
uniprot_sec
Q9DAH4
resolver
amino_acid_sequence
MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPASAAASPAAATAAAAASAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLEASFQQADPGCTSDSQPHAFLISGPASPGTSSATSSPLKKEQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASYVS
uniprot
proteins
function
FUNCTION: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:25107474, PubMed:26041538, PubMed:27871306, PubMed:30116001, PubMed:30801883). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (By similarity). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (PubMed:18066067, PubMed:25107474). Also involved in adaptive immunity by promoting B-cell activation (PubMed:26041538). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (PubMed:27871306). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (PubMed:30801883). Also plays a role in facilitating interdigital tissue regression during limb development (PubMed:30116001). {ECO:0000250|UniProtKB:Q53H80, ECO:0000269|PubMed:18066067, ECO:0000269|PubMed:25107474, ECO:0000269|PubMed:26041538, ECO:0000269|PubMed:27871306, ECO:0000269|PubMed:30116001, ECO:0000269|PubMed:30801883}.
uniprot
proteins
mass_dalton
22113
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated. Polyubiquitination is dependent of UBR5 that extends pre-ubiquitinated AKIRIN2. {ECO:0000250|UniProtKB:Q53H80}.
uniprot
proteins
protein_family
Akirin family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18066067
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25107474
uniprot
proteins
pubmed
26041538
uniprot
proteins
pubmed
27871306
uniprot
proteins
pubmed
30116001
uniprot
proteins
pubmed
30801883
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25107474, ECO:0000269|PubMed:30116001, ECO:0000269|PubMed:30801883}. Cytoplasm {ECO:0000269|PubMed:30801883}. Membrane {ECO:0000269|PubMed:30801883}. Note=Present mainly in the nuclear fraction, and at much lower level in the cytoplasmic and membrane fractions. {ECO:0000269|PubMed:30801883}.
uniprot
proteins