Hsf4
entrez
26386
canonical
uniprot
Q9R0L1
canonical
ensembl
ENSMUSG00000033249
resolver
ensp
ENSMUSP00000048904
resolver
ensp
ENSMUSP00000126278
resolver
ensp
ENSMUSP00000134213
resolver
ensp
ENSMUSP00000306996
resolver
ensp
ENSMUSP00000306998
resolver
enst
ENSMUST00000163734
resolver
genesymbol
Hsf4
resolver
uniprot
B2RQY2
resolver
uniprot
F6Z6B7
resolver
uniprot
Q3UG93
resolver
uniprot
Q9R0L2
resolver
uniprot_entry
B2RQY2_MOUSE
resolver
uniprot_entry
F6Z6B7_MOUSE
resolver
uniprot_entry
HSF4_MOUSE
resolver
uniprot_entry
Q3UG93_MOUSE
resolver
uniprot_sec
Q9R0L2
resolver
amino_acid_sequence
MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRKVPALRGDDSRWRPEDLSRLLGEVQALRGVQESTEARLQELRQQNEILWREVVTLRQSHSQQHRVIGKLIQCLFGPLQTGPSSTGAKRKLSLMLDEGSACSASAKFNACPVSGALLQDPYFIQSPLPETTLGLSPHRARGPIISDIPEDSPSPEGHRLSPSGGCRRVKGLALLKEEPASPGGDGEAGLALAPNECDFCVTAPPPLPVAVVQAILEGKGSYSPEGPRSVQQPEPRGPREVPDRGTLGLDRGNRSPESLLPPMLLRPAPETLEPVAPVDVLGPSLHGREWTLMDLDMELSLMQPLAPETDEAELTVKELNSSGVGKDHTLGTPLMLDVQADLEGAALSVPGALTLYNVTESNASYLDPGASPSSP
uniprot
proteins
function
FUNCTION: Heat-shock transcription factor that specifically binds heat shock promoter elements (HSE) (By similarity). Required for denucleation and organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light (By similarity). In this process, may regulate denucleation of lens fiber cells in part by activating DNASE2B transcription (By similarity). May be involved in DNA repair through the transcriptional regulation of RAD51 (By similarity). May up-regulate p53/TP53 protein in eye lens fiber cells, possibly through protein stabilization (By similarity). In the eye lens, controls the expression of alpha-crystallin B chain/CRYAB and consequently may be involved in the regulation of lysosomal acidification (PubMed:31786107). {ECO:0000250|UniProtKB:Q5CZP2, ECO:0000250|UniProtKB:Q9ULV5, ECO:0000269|PubMed:31786107}.; FUNCTION: [Isoform HSF4A]: Transcriptional repressor. {ECO:0000269|PubMed:10488131}.; FUNCTION: [Isoform HSF4B]: Transcriptional activator. {ECO:0000269|PubMed:10488131}.
uniprot
proteins
mass_dalton
53255
uniprot
proteins
post_translational_modification
PTM: Phosphorylated mainly on serine residues. Phosphorylation on Ser-298 promotes sumoylation on Lys-293 (By similarity). {ECO:0000250}.; PTM: Isoform HSF4B is constitutively sumoylated. Sumoylation represses the transcriptional activity and is promoted by phosphorylation on Ser-298. HSFA is not sumoylated (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
HSF family
uniprot
proteins
pubmed
10488131
uniprot
proteins
pubmed
16581800
uniprot
proteins
pubmed
31786107
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9ULV5}.
uniprot
proteins