KRT15
entrez
3866
canonical
uniprot
P19012
canonical
ensembl
ENSG00000171346
resolver
ensp
ENSP00000254043
resolver
ensp
ENSP00000765882
resolver
genesymbol
KRT15
resolver
genesymbol_syn
KRTB
resolver
hgnc
HGNC:6421
resolver
uniprot
B3KQY1
resolver
uniprot
B3KRA2
resolver
uniprot
B3KVF5
resolver
uniprot
E0CX14
resolver
uniprot
Q53XV8
resolver
uniprot
Q9BUG4
resolver
uniprot_entry
B3KVF5_HUMAN
resolver
uniprot_entry
K1C15_HUMAN
resolver
uniprot_sec
B3KQY1
resolver
uniprot_sec
B3KRA2
resolver
uniprot_sec
E0CX14
resolver
uniprot_sec
Q53XV8
resolver
uniprot_sec
Q9BUG4
resolver
amino_acid_sequence
MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSISASSARFVSSGSGGGYGGGMRVCGFGGGAGSVFGGGFGGGVGGGFGGGFGGGDGGLLSGNEKITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQTPTSPECDYSQYFKTIEELRDKIMATTIDNSRVILEIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGIAIREASSGGGGSSSNFHINVEESVDGQVVSSHKREI
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in the epithelium. Forms heteropolymers with type II keratin KRT5, assembling into keratin intermediate filament network that promotes mechanical resilience of undifferentiated cells, including hair follicle bulge cells, foregut basal progenitors and intestinal crypt cells. Displays an antagonist role with KRT14 in basal epithelial cells, where KRT14 promotes cell differentiation while KRT15 maintains the progenitor state and promotes proliferation and clonogenicity (PubMed:41511042). Promotes the progenitor state in basal keratinocytes by maintaining cytoplasmic YAP1 less effectively than KRT14 due to missing biochemical motifs, thereby allowing higher YAP1 nuclear activity (PubMed:41511042). Also contributes to epithelial cell regeneration after injury. In the absence of KRT14, forms a bona fide, but ultrastructurally distinct keratin filament network with KRT5 (By similarity). {ECO:0000250|UniProtKB:Q61414, ECO:0000269|PubMed:41511042}.
uniprot
proteins
mass_dalton
49212
uniprot
proteins
mutagenesis
MUTAGEN 29..33; /note="GFGGG->SCRAP: Increased interaction with SFN. Increased SFN-YAP1 proximity."; /evidence="ECO:0000269|PubMed:41511042"; MUTAGEN 351; /note="A->C: Induction of YAP1 cytoplasmic sequestration. Increased SFN-YAP1 proximity."; /evidence="ECO:0000269|PubMed:41511042
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
10084315
uniprot
proteins
pubmed
10623642
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2452170
uniprot
proteins
pubmed
2468493
uniprot
proteins
pubmed
27812135
uniprot
proteins
pubmed
36512409
uniprot
proteins
pubmed
41511042
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q61414}.
uniprot
proteins