Skp2
entrez
27401
canonical
uniprot
Q9Z0Z3
canonical
ensembl
ENSMUSG00000054115
resolver
ensp
ENSMUSP00000094225
resolver
ensp
ENSMUSP00000139997
resolver
enst
ENSMUST00000190131
resolver
genesymbol
Skp2
resolver
uniprot
A0A087WQ11
resolver
uniprot
Q569Z9
resolver
uniprot
Q8BSG7
resolver
uniprot
Q8C8Y9
resolver
uniprot
Q8CB22
resolver
uniprot
Q99J53
resolver
uniprot_entry
A0A087WQ11_MOUSE
resolver
uniprot_entry
Q569Z9_MOUSE
resolver
uniprot_entry
SKP2_MOUSE
resolver
uniprot_sec
Q8BSG7
resolver
uniprot_sec
Q8C8Y9
resolver
uniprot_sec
Q8CB22
resolver
uniprot_sec
Q99J53
resolver
amino_acid_sequence
MHRKHLQEIPDQSGNVTTSFTWGWDSSKTSELLSGMGVSALEKEEVDSENIPHGLLSNLGHPQSPPRKRVKGKGSDKDFVIIRRPKLSRENFPGVSWDSLPDELLLGIFSCLCLPELLRVSGVCKRWYRLSLDESLWQSLDLAGKNLHPDVTVRLLSRGVVAFRCPRSFMEQPLGESFSSFRVQHMDLSNSVINVSNLHKILSECSKLQNLSLEGLQLSDPIVKTLAQNENLVRLNLCGCSGFSESAVATLLSSCSRLDELNLSWCFDFTEKHVQAAVAHLPNTITQLNLSGYRKNLQKTDLCTIIKRCPNLIRLDLSDSIMLKNDCFPEFFQLNYLQHLSLSRCYDIIPDTLLELGEIPTLKTLQVFGIVPEGTLQLLREALPRLQINCAYFTTIARPTMDSKKNLEIWGIKCRLTLQKPSCL
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:22464731). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (PubMed:10790373). Degradation of CDKN1B/p27kip also requires CKS1 (PubMed:10790373). Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:22464731). Degradation of TAL1 also requires STUB1 (By similarity). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (By similarity). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (By similarity). Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination (PubMed:22464731). {ECO:0000250|UniProtKB:Q13309, ECO:0000269|PubMed:10790373, ECO:0000269|PubMed:22464731}.; FUNCTION: Through the ubiquitin-mediated proteasomal degradation of viral proteins may have an antiviral activity. {ECO:0000250|UniProtKB:Q13309}.
uniprot
proteins
mass_dalton
47766
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:22464731}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine resudues in response to DNA damage, promoting 'Lys-63'-linked ubiquitination of NBN. {ECO:0000269|PubMed:22464731}.; PTM: Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Deubiquitinated by USP13 (By similarity). {ECO:0000250|UniProtKB:Q13309}.; PTM: Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes cytoplasmic retention. Deacetylated by SIRT3 (By similarity). {ECO:0000250|UniProtKB:Q13309}.
uniprot
proteins
pubmed
10790373
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22464731
uniprot
proteins
pubmed
30366907
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q13309}. Nucleus {ECO:0000250|UniProtKB:Q13309}.
uniprot
proteins