GABRQ
entrez
55879
canonical
uniprot
Q9UN88
canonical
ensembl
ENSG00000268089
resolver
ensp
ENSP00000469332
resolver
ensp
ENSP00000735038
resolver
enst
ENST00000598523
resolver
genesymbol
GABRQ
resolver
hgnc
HGNC:14454
resolver
uniprot
A6NFN1
resolver
uniprot
Q32MB4
resolver
uniprot
Q9NZK8
resolver
uniprot_entry
GBRT_HUMAN
resolver
uniprot_sec
A6NFN1
resolver
uniprot_sec
Q32MB4
resolver
uniprot_sec
Q9NZK8
resolver
activity_regulation
ACTIVITY REGULATION: Potentiated by etomidate, propofol, pregnanolone and pentobarbital. {ECO:0000269|PubMed:16412217}.
uniprot
proteins
amino_acid_sequence
MGIRGMLRAAVILLLIRTWLAEGNYPSPIPKFHFEFSSAVPEVVLNLFNCKNCANEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRRQPRRHRRPRRVIARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASPESLGSLTSTSEQAQLATSESLSPLTSLSGQAPLATGESLSDLPSTSEQARHSYGVRFNGFQADDSIIPTEIRNRVEAHGHGVTHDHEDSNESLSSDERHGHGPSGKPMLHHGEKGVQEAGWDLDDNNDKSDCLAIKEQFKCDTNSTWGLNDDELMAHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFNPDYVPKVDKWSRFLFPLAFGLFNIVYWVYHMY
uniprot
proteins
function
FUNCTION: Theta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:16412217). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10449790, PubMed:16412217). {ECO:0000250|UniProtKB:P47870, ECO:0000269|PubMed:10449790, ECO:0000269|PubMed:16412217}.
uniprot
proteins
mass_dalton
71988
uniprot
proteins
protein_family
GABRQ sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
10449790
uniprot
proteins
pubmed
10804200
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16412217
uniprot
proteins
sequence_length
632
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000255}. Cell membrane; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 269..289; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 298..315; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 327..347; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 612..632; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins