Mc5r
entrez
25726
canonical
uniprot
P35345
canonical
ensembl
ENSRNOG00000016685
resolver
ensembl
ENSRNOG00055010584
resolver
ensembl
ENSRNOG00060009340
resolver
ensembl
ENSRNOG00065023401
resolver
ensp
ENSRNOP00000022364
resolver
ensp
ENSRNOP00055014424
resolver
ensp
ENSRNOP00060012283
resolver
ensp
ENSRNOP00065032501
resolver
enst
ENSRNOT00000022364
resolver
enst
ENSRNOT00055017915
resolver
enst
ENSRNOT00060015752
resolver
enst
ENSRNOT00065039984
resolver
genesymbol
Mc5r
resolver
uniprot_entry
MC5R_RAT
resolver
amino_acid_sequence
MNSSSHLTLLDLTLNASEDNILGQNVNNKSSACEDMGIAVEVFLTLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETITIYLINNKHVVIADTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALRYHHIMTARRSGVIIACIWTFCISCGIVFIIYYESKYVIVCLISMFFTMLFFMVSLYIHMFLLARNHVKRIAASPRYNSVRQRASMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNVYCACFMSYFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIICCHGFRRTCTLLGRY
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for melanocyte-stimulating hormones (alpha- beta- and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway. Also activates ERK1/2 via a PI3K-dependent signaling mechanism. Order of potency of natural melanocortins in receptor activation is alpha-MSH > ACTH > beta-MSH > gamma-MSH (By similarity). Plays a key role in immune response, and is essential for temperature regulation and exocrine gland function (By similarity). {ECO:0000250|UniProtKB:P33032, ECO:0000250|UniProtKB:P41149}.
uniprot
proteins
mass_dalton
37050
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
8179577
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 38..61; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 74..97; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 115..138; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 156..179; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 187..211; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 240..265; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 274..297; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins