SGK2
entrez
10110
canonical
uniprot
Q9HBY8
canonical
ensembl
ENSG00000101049
resolver
ensp
ENSP00000340608
resolver
ensp
ENSP00000362192
resolver
ensp
ENSP00000392795
resolver
genesymbol
SGK2
resolver
hgnc
HGNC:13900
resolver
uniprot
Q52PK5
resolver
uniprot
Q5H8Y6
resolver
uniprot
Q5H8Z1
resolver
uniprot
Q5TZR3
resolver
uniprot
Q9UKG6
resolver
uniprot_entry
SGK2_HUMAN
resolver
uniprot_sec
Q52PK5
resolver
uniprot_sec
Q5H8Y6
resolver
uniprot_sec
Q5H8Z1
resolver
uniprot_sec
Q5TZR3
resolver
uniprot_sec
Q9UKG6
resolver
activity_regulation
ACTIVITY REGULATION: Two specific sites, one in the kinase domain (Thr-193) and the other in the C-terminal regulatory region (Ser-356), need to be phosphorylated for its full activation.
uniprot
proteins
amino_acid_sequence
MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPEDDDILDC
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. {ECO:0000269|PubMed:12397388, ECO:0000269|PubMed:12590200, ECO:0000269|PubMed:12632189, ECO:0000269|PubMed:12634932, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:20511718, ECO:0000269|PubMed:21865597}.
uniprot
proteins
mass_dalton
41175
uniprot
proteins
mutagenesis
MUTAGEN 356; /note="S->D: Increased activation."; /evidence="ECO:0000269|PubMed:10548550
uniprot
proteins
post_translational_modification
PTM: Activated by phosphorylation on Ser-356 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-193. {ECO:0000269|PubMed:10548550}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10548550
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12397388
uniprot
proteins
pubmed
12590200
uniprot
proteins
pubmed
12632189
uniprot
proteins
pubmed
12634932
uniprot
proteins
pubmed
15040001
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16460280
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
20511718
uniprot
proteins
pubmed
20919962
uniprot
proteins
pubmed
21865597
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21865597}. Nucleus {ECO:0000269|PubMed:21865597}.
uniprot
proteins