St6gal1
entrez
20440
canonical
uniprot
Q64685
canonical
ensembl
ENSMUSG00000022885
resolver
ensp
ENSMUSP00000023601
resolver
ensp
ENSMUSP00000110992
resolver
ensp
ENSMUSP00000136206
resolver
ensp
ENSMUSP00000262935
resolver
ensp
ENSMUSP00000262947
resolver
ensp
ENSMUSP00000262950
resolver
ensp
ENSMUSP00000262952
resolver
enst
ENSMUST00000023601
resolver
enst
ENSMUST00000115335
resolver
enst
ENSMUST00000178797
resolver
genesymbol
St6gal1
resolver
genesymbol_syn
Siat1
resolver
uniprot
Q8BM62
resolver
uniprot
Q8K1L1
resolver
uniprot_entry
Q8BM62_MOUSE
resolver
uniprot_entry
SIAT1_MOUSE
resolver
uniprot_sec
Q8K1L1
resolver
amino_acid_sequence
MIHTNLKRKFSCFVLVFLLFAIICVWKKGSDYEALTLQAKVFQMPKSQEKVAVGPAPQAVFSNSKQDPKEGVQILSYPRVTAKVKPQPSLQVWDKDSTYSKLNPRLLKIWRNYLNMNKYKVSYKGPGPGVKFSVEALRCHLRDHVNVSMIEATDFPFNTTEWEGYLPKENFRTKAGPWHKCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGTKTTIRLVNSQLVTTEKRFLKDSLYTEGILILWDPSVYHADIPQWYQKPDYNFFETYKSYRRLHPSQPFYILKPQMPWELWDIIQEISPDLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYHPLLFEKNMVKHLNEGTDEDIYLFGKATLSGFRNNRC
uniprot
proteins
ec_number
2.4.3.1
uniprot
proteins
function
FUNCTION: Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates (PubMed:22039275). Sialylates complex-type N-glycans attached on the fragment crystallizable (Fc) of IgGs conferring anti-inflammatory effector functions. Preferentially monosialylates the alpha(1->3) mannose antenna of Fc glycoforms with subsequent disialylation occurring at a much slower rate (By similarity). {ECO:0000250|UniProtKB:P15907, ECO:0000269|PubMed:22039275}.
uniprot
proteins
mass_dalton
46586
uniprot
proteins
mutagenesis
MUTAGEN 139; /note="C->A,S: No effect on enzyme activity."; /evidence="ECO:0000269|PubMed:22039275"; MUTAGEN 181; /note="C->S: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:22039275"; MUTAGEN 350; /note="C->A,S: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:22039275
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:22039275}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P13721}.
uniprot
proteins
protein_family
Glycosyltransferase 29 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22039275
uniprot
proteins
pubmed
8081843
uniprot
proteins
sequence_length
403
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P15907}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P15907}. Secreted {ECO:0000250|UniProtKB:P13721}. Note=Membrane-bound form in trans cisternae of Golgi (By similarity). Secreted into the body fluid (By similarity). Colocalizes with MGAT3 and B4GALT1 in the Golgi stacks of cisternae, including the cis-part of the Golgi stacks. {ECO:0000250|UniProtKB:P13721, ECO:0000250|UniProtKB:P15907}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..26; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins