Drc4
entrez
104346
canonical
uniprot
Q60779
canonical
ensembl
ENSMUSG00000040220
resolver
ensp
ENSMUSP00000090730
resolver
enst
ENSMUST00000093043
resolver
genesymbol
Drc4
resolver
genesymbol
Gas8
resolver
genesymbol_syn
Gas11
resolver
genesymbol_syn
Gas8
resolver
uniprot
Q49MD7
resolver
uniprot
Q99L71
resolver
uniprot_entry
DRC4_MOUSE
resolver
uniprot_entry
Q49MD7_MOUSE
resolver
uniprot_sec
Q99L71
resolver
amino_acid_sequence
MAPKKKGKKGKAKGTAIVDGVAPEDMTKEQVEEHVARIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLAEVKAEGTVVMKLAQKEHRTQEGALRKDMRVLKVELKEQELANEVVIKNLCLKQAEEITKMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTEIHEVEERKNGQISTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEEHMEREMAEVTLQNRRLADPLQKAKDEMNEMQKRLGNHERDKQILVCTKARLKVAERELKDLKWEHEVLEQRFIKVQQEREELYRKFADAIQEVQQKTGFKNLLLERKLQALNAAVEKREVQFNEVLAASNLDPTALTLVSRKLEDVLESKNTTIKDLQYELARVCKAHNDLLRTYEAKLLAFGIPLDNVGFKPLETAVIGQTLGQGPAGLVGAPT
uniprot
proteins
function
FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (PubMed:17366626, PubMed:21659505, PubMed:27472056). May play a role in the spermatozoa motility (PubMed:11751847). {ECO:0000250|UniProtKB:Q7XJ96, ECO:0000269|PubMed:11751847, ECO:0000269|PubMed:17366626, ECO:0000269|PubMed:21659505, ECO:0000269|PubMed:27472056}.
uniprot
proteins
mass_dalton
56264
uniprot
proteins
mutagenesis
MUTAGEN 391; /note="A->V: Moderate decrease in cilia motility."; /evidence="ECO:0000269|PubMed:27472056
uniprot
proteins
protein_family
DRC4 family
uniprot
proteins
pubmed
11751847
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16643277
uniprot
proteins
pubmed
17366626
uniprot
proteins
pubmed
18396146
uniprot
proteins
pubmed
21659505
uniprot
proteins
pubmed
26387594
uniprot
proteins
pubmed
27472056
uniprot
proteins
pubmed
31961863
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11751847, ECO:0000269|PubMed:21659505}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17366626}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:11751847, ECO:0000269|PubMed:31961863}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:11751847, ECO:0000269|PubMed:26387594, ECO:0000269|PubMed:27472056}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:16643277, ECO:0000269|PubMed:21659505}. Golgi apparatus {ECO:0000269|PubMed:18396146}. Cell projection, cilium {ECO:0000269|PubMed:27472056}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q7XJ96}. Note=Associates with microtubules (PubMed:17366626). Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa (PubMed:11751847). {ECO:0000269|PubMed:11751847, ECO:0000269|PubMed:17366626}.
uniprot
proteins