IL4R
entrez
3566
canonical
uniprot
P24394
canonical
ensembl
ENSG00000077238
resolver
ensp
ENSP00000170630
resolver
ensp
ENSP00000379111
resolver
ensp
ENSP00000441667
resolver
ensp
ENSP00000526418
resolver
ensp
ENSP00000526425
resolver
ensp
ENSP00000526427
resolver
ensp
ENSP00000526432
resolver
ensp
ENSP00000788932
resolver
genesymbol
IL4R
resolver
genesymbol_syn
IL4RA
resolver
hgnc
HGNC:6015
resolver
uniprot
B2RBY1
resolver
uniprot
B4E076
resolver
uniprot
B9EKU8
resolver
uniprot
H3BSY5
resolver
uniprot
Q96P01
resolver
uniprot
Q9H181
resolver
uniprot
Q9H182
resolver
uniprot
Q9H183
resolver
uniprot
Q9H184
resolver
uniprot
Q9H185
resolver
uniprot
Q9H186
resolver
uniprot
Q9H187
resolver
uniprot
Q9H188
resolver
uniprot_entry
B2RBY1_HUMAN
resolver
uniprot_entry
IL4RA_HUMAN
resolver
uniprot_sec
B4E076
resolver
uniprot_sec
B9EKU8
resolver
uniprot_sec
H3BSY5
resolver
uniprot_sec
Q96P01
resolver
uniprot_sec
Q9H181
resolver
uniprot_sec
Q9H182
resolver
uniprot_sec
Q9H183
resolver
uniprot_sec
Q9H184
resolver
uniprot_sec
Q9H185
resolver
uniprot_sec
Q9H186
resolver
uniprot_sec
Q9H187
resolver
uniprot_sec
Q9H188
resolver
amino_acid_sequence
MGWLCSGLLFPVSCLVLLQVASSGNMKVLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVRAWAQCYNTTWSEWSPSTKWHNSYREPFEQHLLLGVSVSCIVILAVCLLCYVSITKIKKEWWDQIPNPARSRLVAIIIQDAQGSQWEKRSRGQEPAKCPHWKNCLTKLLPCFLEHNMKRDEDPHKAAKEMPFQGSGKSAWCPVEISKTVLWPESISVVRCVELFEAPVECEEEEEVEEEKGSFCASPESSRDDFQEGREGIVARLTESLFLDLLGEENGGFCQQDMGESCLLPPSGSTSAHMPWDEFPSAGPKEAPPWGKEQPLHLEPSPPASPTQSPDNLTCTETPLVIAGNPAYRSFSNSLSQSPCPRELGPDPLLARHLEEVEPEMPCVPQLSEPTTVPQPEPETWEQILRRNVLQHGAAAAPVSAPTSGYQEFVHAVEQGGTQASAVVGLGPPGEAGYKAFSSLLASSAVSPEKCGFGASSGEEGYKPFQDLIPGCPGDPAPVPVPLFTFGLDREPPRSPQSSHLPSSSPEHLGLEPGEKVEDMPKPPLPQEQATDPLVDSLGSGIVYSALTCHLCGHLKQCHGQEDGGQTPVMASPCCGCCCGDRSSPPTTPLRAPDPSPGGVPLEASLCPASLAPSGISEKSKSSSSFHPAPGNAQSSSQTPKIVNFVSVGPTYMRVS
uniprot
proteins
function
FUNCTION: Receptor for both interleukin 4 and interleukin 13 (PubMed:17030238). Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. {ECO:0000269|PubMed:17030238, ECO:0000269|PubMed:8124718}.; FUNCTION: Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. {ECO:0000269|PubMed:8124718}.
uniprot
proteins
mass_dalton
89658
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="Y->A: 700-fold reduction in IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 38; /note="Y->F: 25-fold reduction in IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 39; /note="M->A: No effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 40; /note="S->A: No effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 64; /note="L->A: 100-fold reduction in IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 66; /note="F->A: 45-fold reduction in IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 67; /note="L->A: No effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 68; /note="L->A: No effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 91; /note="D->A: Little effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 92; /note="D->A: 50-fold reduction in IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 93; /note="V->A: Little effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 94; /note="V->A: 35-fold reduction in IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 95; /note="S->A: No effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 97; /note="D->A,N: >150-fold reduction in IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 98; /note="N->A: No effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 99; /note="Y->A: 10-fold reduction in IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 116; /note="K->A: Little effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 117; /note="P->A: Little effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 118; /note="S->A: No effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 119; /note="E->A: No effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 150; /note="D->A: Little effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 151; /note="N->A: Little effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 152; /note="Y->A: 40-fold reduction in IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 152; /note="Y->F: No effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 153; /note="L->A: Little effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 154; /note="Y->A: Little effect on IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 208; /note="Y->A: 500-fold reduction in IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 208; /note="Y->F: 200-fold reduction in IL4 binding."; /evidence="ECO:0000269|PubMed:11786020"; MUTAGEN 497; /note="Y->F: Abolishes IRS1 tyrosine phosphorylation. No cell proliferation."; /evidence="ECO:0000269|PubMed:8124718"; MUTAGEN 575; /note="Y->F: Loss of CD23 gene induction; when associated with F-603 and F-631."; /evidence="ECO:0000269|PubMed:10201973, ECO:0000269|PubMed:8624803"; MUTAGEN 603; /note="Y->F: Loss of CD23 gene induction; when associated with F-575 and F-631."; /evidence="ECO:0000269|PubMed:8624803"; MUTAGEN 631; /note="Y->F: Loss of CD23 gene induction; when associated with F-575 and F-603."; /evidence="ECO:0000269|PubMed:8624803"; MUTAGEN 713; /note="Y->F: Increased IL4-induced cell proliferation and STAT6 activation."; /evidence="ECO:0000269|PubMed:11714803
uniprot
proteins
post_translational_modification
PTM: On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction. {ECO:0000269|PubMed:8624803}.; PTM: The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase. {ECO:0000269|PubMed:10341317}.
uniprot
proteins
protein_family
Type 4 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
10201973
uniprot
proteins
pubmed
10219247
uniprot
proteins
pubmed
10233717
uniprot
proteins
pubmed
10341317
uniprot
proteins
pubmed
10390422
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
10590262
uniprot
proteins
pubmed
10677312
uniprot
proteins
pubmed
10809862
uniprot
proteins
pubmed
11285129
uniprot
proteins
pubmed
11513543
uniprot
proteins
pubmed
11714803
uniprot
proteins
pubmed
11786020
uniprot
proteins
pubmed
12459556
uniprot
proteins
pubmed
14657871
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17030238
uniprot
proteins
pubmed
2278997
uniprot
proteins
pubmed
2307934
uniprot
proteins
pubmed
7538655
uniprot
proteins
pubmed
7721895
uniprot
proteins
pubmed
7775445
uniprot
proteins
pubmed
8124718
uniprot
proteins
pubmed
8624803
uniprot
proteins
pubmed
8804422
uniprot
proteins
pubmed
9070874
uniprot
proteins
pubmed
9392697
uniprot
proteins
pubmed
9620765
uniprot
proteins
sequence_length
825
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 233..256; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins