Cpe
entrez
12876
canonical
uniprot
Q00493
canonical
ensembl
ENSMUSG00000037852
resolver
ensp
ENSMUSP00000048555
resolver
enst
ENSMUST00000048967
resolver
genesymbol
Cpe
resolver
uniprot
Q543R4
resolver
uniprot
Q64439
resolver
uniprot_entry
CBPE_MOUSE
resolver
uniprot_entry
Q543R4_MOUSE
resolver
uniprot_sec
Q64439
resolver
amino_acid_sequence
MAGRGGRVLLALCAALVAGGWLLTAEAQEPGAPAAGMRRRRRLQQEDGISFEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEPGEPEFKYIGNMHGNEAVGRELLIFLAQYLCNEYQKGNETIVNLIHSTRIHIMPSLNPDGFEKAASQPGELKDWFVGRSNAQGIDLNRNFPDLDRIVYVNEKEGGPNNHLLKNLKKIVDQNSKLAPETKAVIHWIMDIPFVLSANLHGGDLVANYPYDETRSGTAHEYSSCPDDAIFQSLARAYSSFNPVMSDPNRPPCRKNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKSYWEDNKNSLISYLEQIHRGVKGFVRDLQGNPIANATISVDGIDHDVTSAKDGDYWRLLAPGNYKLTASAPGYLAITKKVAVPFSPAVGVDFELESFSERKEEEKEELMEWWKMMSETLNF
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Cpe are the cause of the fat phenotype. Mice homozygous for the fat mutation develop obesity and hyperglycemia that can be suppressed by treatment with exogenous insulin. {ECO:0000269|PubMed:7663508}.
uniprot
proteins
ec_number
3.4.17.10
uniprot
proteins
function
FUNCTION: Sorting receptor that directs prohormones to the regulated secretory pathway. Also acts as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. {ECO:0000269|PubMed:10896946, ECO:0000269|PubMed:16219686}.
uniprot
proteins
mass_dalton
53256
uniprot
proteins
protein_family
Peptidase M14 family
uniprot
proteins
pubmed
10896946
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16219686
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7663508
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:16219686}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P15087}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15087}. Secreted {ECO:0000250|UniProtKB:P15087}. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. {ECO:0000269|PubMed:10896946}.
uniprot
proteins