MEOX2
entrez
4223
canonical
uniprot
P50222
canonical
ensembl
ENSG00000106511
resolver
ensp
ENSP00000262041
resolver
enst
ENST00000262041
resolver
genesymbol
MEOX2
resolver
genesymbol_syn
GAX
resolver
genesymbol_syn
MOX2
resolver
hgnc
HGNC:7014
resolver
uniprot
A4D127
resolver
uniprot
B2R8I7
resolver
uniprot
O75263
resolver
uniprot
Q9UPL6
resolver
uniprot_entry
MEOX2_HUMAN
resolver
uniprot_sec
A4D127
resolver
uniprot_sec
B2R8I7
resolver
uniprot_sec
O75263
resolver
uniprot_sec
Q9UPL6
resolver
amino_acid_sequence
MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHHQQQQHQALQTNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPAEAEKRSGGKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTGDSIANEDSHDSDHSSEHAHL
uniprot
proteins
function
FUNCTION: Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212, PubMed:22206000). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed:17074759, PubMed:22206000). While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity). {ECO:0000250|UniProtKB:P32443, ECO:0000250|UniProtKB:P39020, ECO:0000269|PubMed:17074759, ECO:0000269|PubMed:20516212, ECO:0000269|PubMed:22206000}.
uniprot
proteins
mass_dalton
33594
uniprot
proteins
mutagenesis
MUTAGEN 236; /note="Q->E: Abolishes DNA-binding. Does not affect ability to activate expression of CDKN2A."; /evidence="ECO:0000269|PubMed:22206000
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335786
uniprot
proteins
pubmed
17074759
uniprot
proteins
pubmed
19266028
uniprot
proteins
pubmed
19760604
uniprot
proteins
pubmed
20516212
uniprot
proteins
pubmed
22206000
uniprot
proteins
pubmed
7607679
uniprot
proteins
pubmed
7713505
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19266028, ECO:0000269|PubMed:22206000}. Nucleus speckle {ECO:0000269|PubMed:19266028}.
uniprot
proteins