Rad23a
entrez
19358
canonical
uniprot
P54726
canonical
ensembl
ENSMUSG00000003813
resolver
ensp
ENSMUSP00000003911
resolver
ensp
ENSMUSP00000105383
resolver
ensp
ENSMUSP00000115664
resolver
ensp
ENSMUSP00000317057
resolver
ensp
ENSMUSP00000317061
resolver
ensp
ENSMUSP00000357354
resolver
enst
ENSMUST00000003911
resolver
enst
ENSMUST00000109761
resolver
enst
ENSMUST00000128035
resolver
genesymbol
Rad23a
resolver
genesymbol_syn
Mhr23a
resolver
uniprot
B7ZNQ1
resolver
uniprot
F6SXP8
resolver
uniprot
F8WHJ0
resolver
uniprot
Q3TN85
resolver
uniprot
Q8BRA9
resolver
uniprot
Q8CAP3
resolver
uniprot_entry
F6SXP8_MOUSE
resolver
uniprot_entry
F8WHJ0_MOUSE
resolver
uniprot_entry
Q3TN85_MOUSE
resolver
uniprot_entry
Q8BRA9_MOUSE
resolver
uniprot_entry
Q8CAP3_MOUSE
resolver
uniprot_entry
RD23A_MOUSE
resolver
uniprot_sec
B7ZNQ1
resolver
amino_acid_sequence
MAVTITLKTLQQQTFKIRMEPDETVKVLKEKIEAEKGRDAFPVAGQKLIYAGKILSDDVPIKEYHIDEKNFVVVMVTKAKAGQGIPAPPEASPTAVPEPSTPFPPVLASGMSHPPPTSREDKSPSEESTTTTSPESISGSVPSSGSSGREEDAASTLVTGSEYETMLTEIMSMGYERERVVAALRASYNNPHRAVEYLLTGIPGSPEPEHGSVQESQAPEQPATEAAGENPLEFLRDQPQFQNMRQVIQQNPALLPALLQQLGQENPQLLQQISRHQEQFIQMLNEPPGELADISDVEGEVGAIGEEAPQMNYIQVTPQEKEAIERLKALGFPESLVIQAYFACEKNENLAANFLLSQNFDDE
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
function
FUNCTION: Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation, transcriptional regulation, and viral replication. Specifically demethylates mono-, di- and trimethylated 'Lys-20' of histone H4 (H4K20me1, H4K20me2, H4K20me3, respectively) into unmethylated forms. Activates the transcription of coding genes by demethylating H4K20me1 and the transcription of repetitive elements by demethylating H4K20me3. Involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in nucleotide excision repair, is considered functionally equivalent to RAD23B in global genome nucleotide excision repair (GG-NER) through its association with XPC. In vitro, the XPC-RAD23A complex demonstrates NER activity. Can stabilize XPC. {ECO:0000269|PubMed:12815074, ECO:0000269|PubMed:15336624}.
uniprot
proteins
mass_dalton
39706
uniprot
proteins
protein_family
RAD23 family
uniprot
proteins
pubmed
12815074
uniprot
proteins
pubmed
15336624
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8808275
uniprot
proteins
sequence_length
363
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P54725}.
uniprot
proteins