Hcn3
entrez
15168
canonical
uniprot
O88705
canonical
ensembl
ENSMUSG00000028051
resolver
ensp
ENSMUSP00000029686
resolver
ensp
ENSMUSP00000290965
resolver
enst
ENSMUST00000029686
resolver
genesymbol
Hcn3
resolver
genesymbol_syn
Hac3
resolver
uniprot
B2RRB5
resolver
uniprot_entry
B2RRB5_MOUSE
resolver
uniprot_entry
HCN3_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Unlike HCN2 and HCN4, HCN3 is insensitive to cyclic nucleotides, such as cAMP or cGMP (PubMed:15923185). This lack of sensitivity of HCN3, despite harboring a functional cyclic nucleotide-binding domain (CNBD), may be explained by its shorter C-terminal sequence, which may alter the normal autoinhibition of the channel (Probable). Inhibited by Cs(1+) and ivabradine (PubMed:15923185). Phosphatidylinositol-4,5-bisphosphate (PIP(2)) shifts HCN3 activation to more depolarized potentials and accelerated activation kinetics (PubMed:21753018). {ECO:0000269|PubMed:15923185, ECO:0000269|PubMed:21753018, ECO:0000305|PubMed:15923185}.
uniprot
proteins
amino_acid_sequence
MEEEARPAAGAGEAATPARETPPAAPAQARAASGGVPESAPEPKRRQLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVSMNRMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLRRIGKKNSILQRKRSEPSPGSSGGVMEQHLVQHDRDMARGVRGLAPGTGARLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSARRSAGSPASPLVPVRAGPLLARGPWASTSRLPAPPARTLHASLSRTGRSQVSLLGPPPGGGARRLGPRGRPLSASQPSLPQRATGDGSPRRKGSGSERLPPSGLLAKPPGTVQPPRSSVPEPVTPRGPQISANM
uniprot
proteins
function
FUNCTION: Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions, with an about 3:1 preference for potassium ions (PubMed:15923185). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:21753018, PubMed:21903939, PubMed:31290157). In particular, plays a pivotal role in maintaining excitability and promoting rhythmic burst firing within hypothalamic nuclei (PubMed:31290157). Exerts a significant influence on the configuration of the cardiac action potential waveform (PubMed:21903939). Does not appear to play a prominent role in the processing of acute, neuropathic, or inflammatory pain (PubMed:31290157). {ECO:0000269|PubMed:15923185, ECO:0000269|PubMed:21753018, ECO:0000269|PubMed:21903939, ECO:0000269|PubMed:31290157}.
uniprot
proteins
mass_dalton
86641
uniprot
proteins
protein_family
Potassium channel HCN family
uniprot
proteins
pubmed
12928435
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15923185
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21753018
uniprot
proteins
pubmed
21903939
uniprot
proteins
pubmed
23382386
uniprot
proteins
pubmed
31290157
uniprot
proteins
pubmed
9630217
uniprot
proteins
pubmed
9634236
uniprot
proteins
sequence_length
779
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12928435, ECO:0000269|PubMed:15923185, ECO:0000269|PubMed:23382386}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 97..117; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 124..144; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 171..191; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 201..221; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 253..273; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 329..349; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins