H1-1
entrez
80838
canonical
uniprot
P43275
canonical
ensembl
ENSMUSG00000049539
resolver
ensp
ENSMUSP00000062030
resolver
enst
ENSMUST00000055770
resolver
genesymbol
H1-1
resolver
genesymbol_syn
H1a
resolver
genesymbol_syn
H1f1
resolver
genesymbol_syn
Hist1h1a
resolver
uniprot
Q5SZ98
resolver
uniprot_entry
H11_MOUSE
resolver
uniprot_sec
Q5SZ98
resolver
amino_acid_sequence
MSETAPVAQAASTATEKPAAAKKTKKPAKAAAPRKKPAGPSVSELIVQAVSSSKERSGVSLAALKKSLAAAGYDVEKNNSRIKLGLKSLVNKGTLVQTKGTGAAGSFKLNKKAESKAITTKVSVKAKASGAAKKPKKTAGAAAKKTVKTPKKPKKPAVSKKTSKSPKKPKVVKAKKVAKSPAKAKAVKPKASKAKVTKPKTPAKPKKAAPKKK
uniprot
proteins
function
FUNCTION: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. {ECO:0000250|UniProtKB:P10412}.
uniprot
proteins
mass_dalton
21785
uniprot
proteins
post_translational_modification
PTM: Deamidation of Asn-78 and Asn-79 by CTPS1 in response to DNA damage promotes subsequent acetylation of histone H1 at Lys-77 (H1K75ac). {ECO:0000250|UniProtKB:P10412}.; PTM: Acetylated at Lys-77 (H1K75ac) by EP300 following deamidation of Asn-78 and Asn-79 by CTPS1 in response to DNA damage, thereby increasing chromatin accessibility to facilitate the recruitment of DNA repair proteins. {ECO:0000250|UniProtKB:P10412}.; PTM: H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter. {ECO:0000269|PubMed:8639656}.; PTM: Citrullination at Arg-56 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. {ECO:0000269|PubMed:24463520}.; PTM: Hydroxybutyrylation of histones is induced by starvation. {ECO:0000250|UniProtKB:P43277}.
uniprot
proteins
protein_family
Histone H1/H5 family
uniprot
proteins
pubmed
10666340
uniprot
proteins
pubmed
12408966
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24463520
uniprot
proteins
pubmed
8190634
uniprot
proteins
pubmed
8639656
uniprot
proteins
pubmed
9655912
uniprot
proteins
sequence_length
213
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Mainly localizes in euchromatin. {ECO:0000250}.
uniprot
proteins