Arhgef28
entrez
361882
canonical
uniprot
P0C6P5
canonical
ensembl
ENSRNOG00000016544
resolver
ensp
ENSRNOP00000059196
resolver
ensp
ENSRNOP00000083894
resolver
ensp
ENSRNOP00000101307
resolver
enst
ENSRNOT00000115432
resolver
genesymbol
Arhgef28
resolver
genesymbol_syn
Rgnef
resolver
uniprot
A0A8I5ZW57
resolver
uniprot_entry
A0A8I5ZW57_RAT
resolver
uniprot_entry
ARG28_RAT
resolver
amino_acid_sequence
MELSCSEVPLYGQRTVYAKFGKNVYLPEDAEFYFIYDGSHQRHVVIADRVEDNVLQSIIPGHWLQETVMVSVCLCSEGYSPVTMGSGSVTYVDNMACRLARLLVTQADRLTPCSHQTLLTPFALTAEALPALDEELVLALTQLELPLGWTVLGNSSLEVCLHRESLLHLAVRWALPKLFHFLLCLPGGVKALELPNEEATTPLDLALHGGHSMLVEDISNFQGRRSPGFSRLRLNEDATLQFDRSSETLTLTVNHTAEHLLEADIKLFRKYFWDRAFLVKALDQEAKTERATMPSGAAETEEEVRNLESGRSPSEEEEDGQLVKSQADGPSEQEDQDRLVLDHSFDGLKKSKHAPASLAAGQLSDVPNGGDEVYANCMVIDQVGDLDINYINIEGLSTHTSPESMRSTLGPQACKHILPPDTSPCGHLLCEDSDRTLDAAASQSCMSPPSSHTSNLNLSFGLHGFVKEQSHLKKRSSSLDALVADSEEEGRSEPPICYAVGSQSSPRTGLPGGDELDSFDANTEPDCNISRTESLSLSSTLHSKESLLSGIRSRSYSCSSPKISSGKSRLVRDFTVCSSSEEQRSYSFQEPPGEKRIQEEEWDDYIIPAKAESEKHKVSRTFSFLMNRMTSPRNKSKMKNKDTKDKEKLNRHQFVPGTFSGVLQCSGCDKTLLGKESLQCANCKANTHKGCKDTVPPCTKKFQDKYNKNKPQTILGSSSVRDVPPPGLSLHPSPSMPIGLPAGRKETAGQAHPLSRSVPGTTLESFRRAVTSLESEGDSNSWRSRSHSDELFQSMGSSPSTESFMMEDVVDSSLWSELSSDAQEFEAESWSLVVDPSFCSRQEKDVIKRQDVIFELMQTEVHHIQTLLIMSEVFRKGMKEELQLDHSTVDRIFPCLDELLETHKHFFFSMKERRQESCTGNDRNFVINQIGDILVQQFSEENASKMKRIYGDFCSHHKEAMSLFKELQQNKKFQNFIKIRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHRDLCRALGLIKDMIAAVDLKVSEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSQERALLHDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISASSAGPEMYEIHTSSKEERNNWMRRIQQAVESCPEEEGGRTSESDEERRKADARVAKIQQCQEILSNQDQQICTYLEEKLHIYAELGELSGFEDVHLEPHLLIKPDPGEPPQAASLLAAALREAESLQVAVKASKLADVSQPSEEGPGGAVLADTLSAQDAPASPTAFTEGTEGRGCWDVDPRLQGVVTDLAVSDAGEKVEYRSFSGSSQSEIIQAIQNLTRLLYSLQAALTIQDSHIEIHKLVLQQQESLAPSHSFRGGPLQDQEKSRYLEKHREELANIHKLQYQFQQEQRRWHRTCDQQQREQEAQESWLQARERECQSQEELLLRHRSELDHQLQEYQQNLERLREGQRMVERERQRMRDQQGLLGHCKHSRQRSLPAVFSPGSKEVTELNRAESLCHEKSFFLNDAFTHMSLNTSNKPNPSGAPWDAHPPGGSHLDLARTSDSQIEVKMDVSQPSDVNSELWTTGLGPQRPARQESIKDSCKNVADLNSFQTESPDPQDSNQRGPQPQTLITEAKLTPPMAAGHGGDAGDGAEENIVYL
uniprot
proteins
function
FUNCTION: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis. {ECO:0000269|PubMed:11435431, ECO:0000269|PubMed:12215442}.
uniprot
proteins
mass_dalton
190757
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine upon stimulation of cells by laminin. {ECO:0000250}.
uniprot
proteins
pubmed
11435431
uniprot
proteins
pubmed
12215442
uniprot
proteins
pubmed
12702722
uniprot
proteins
pubmed
14499478
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1700
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with the microtubule radial and cortical systems. {ECO:0000250}.
uniprot
proteins