Gch1
entrez
14528
canonical
uniprot
Q05915
canonical
ensembl
ENSMUSG00000037580
resolver
ensp
ENSMUSP00000087405
resolver
enst
ENSMUST00000089959
resolver
genesymbol
Gch1
resolver
genesymbol_syn
Gch
resolver
uniprot
Q3U7P6
resolver
uniprot_entry
GCH1_MOUSE
resolver
uniprot_entry
Q3U7P6_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: GTP shows a positive allosteric effect, and tetrahydrobiopterin inhibits the enzyme activity. Zinc is required for catalytic activity. Inhibited by Mg(2+). {ECO:0000250|UniProtKB:P30793}.
uniprot
proteins
amino_acid_sequence
MEKPRGVRCTNGFSERELPRPGASPPAEKSRPPEAKGAQPADAWKAGRHRSEEENQVNLPKLAAAYSSILLSLGEDPQRQGLLKTPWRAATAMQYFTKGYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGRVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALQPAGVGVVIEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIRS
uniprot
proteins
ec_number
3.5.4.16
uniprot
proteins
function
FUNCTION: May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. {ECO:0000250|UniProtKB:P30793}.
uniprot
proteins
mass_dalton
27014
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. {ECO:0000250|UniProtKB:P30793}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:P30793}.
uniprot
proteins
protein_family
GTP cyclohydrolase I family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8304101
uniprot
proteins
pubmed
8461009
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P30793}. Nucleus {ECO:0000250|UniProtKB:P30793}.
uniprot
proteins