Rbx1
entrez
56438
canonical
uniprot
P62878
canonical
ensembl
ENSMUSG00000022400
resolver
ensp
ENSMUSP00000023036
resolver
enst
ENSMUST00000023036
resolver
genesymbol
Rbx1
resolver
uniprot
Q8N6Z8
resolver
uniprot
Q9D1S2
resolver
uniprot
Q9WUK9
resolver
uniprot
Q9Y254
resolver
uniprot_entry
RBX1_MOUSE
resolver
uniprot_sec
Q8N6Z8
resolver
uniprot_sec
Q9D1S2
resolver
uniprot_sec
Q9WUK9
resolver
uniprot_sec
Q9Y254
resolver
amino_acid_sequence
MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
ec_number
2.3.2.32
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:22118460, PubMed:33590678, PubMed:35978186). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components (By similarity). As a component of the CSA complex mediates ubiquitination of Pol II subunit RPB1 at 'Lys-1268', a critical TC-NER checkpoint (By similarity). Core component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Core component of a Cul9-RING ubiquitin ligase complex composed of CUL9 and RBX1, which mediates mono-ubiquitination of p53/TP53 (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate (By similarity). Probably also stimulates CDC34 autoubiquitination (By similarity). May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair (By similarity). Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M (By similarity). Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (By similarity). In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM (By similarity). As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (By similarity). {ECO:0000250|UniProtKB:P62877, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:33590678, ECO:0000269|PubMed:35978186}.
uniprot
proteins
mass_dalton
12274
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:35978186}.; PATHWAY: Protein modification; protein neddylation. {ECO:0000250|UniProtKB:P62877}.
uniprot
proteins
protein_family
RING-box family
uniprot
proteins
pubmed
10213691
uniprot
proteins
pubmed
10643962
uniprot
proteins
pubmed
11384984
uniprot
proteins
pubmed
12140560
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22118460
uniprot
proteins
pubmed
24357321
uniprot
proteins
pubmed
33590678
uniprot
proteins
pubmed
35978186
uniprot
proteins
sequence_length
108
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62877}. Nucleus {ECO:0000250|UniProtKB:P62877}.
uniprot
proteins