DDI2
entrez
84301
canonical
uniprot
Q5TDH0
canonical
ensembl
ENSG00000197312
resolver
ensp
ENSP00000417748
resolver
genesymbol
DDI2
resolver
hgnc
HGNC:24578
resolver
uniprot
A8KAE1
resolver
uniprot
Q7RTZ0
resolver
uniprot
Q9BRT1
resolver
uniprot_entry
DDI2_HUMAN
resolver
uniprot_sec
A8KAE1
resolver
uniprot_sec
Q7RTZ0
resolver
uniprot_sec
Q9BRT1
resolver
amino_acid_sequence
MLLTVYCVRRDLSEVTFSLQVDADFELHNFRALCELESGIPAAESQIVYAERPLTDNHRSLASYGLKDGDVVILRQKENADPRPPVQFPNLPRIDFSSIAVPGTSSPRQRQPPGTQQSHSSPGEITSSPQGLDNPALLRDMLLANPHELSLLKERNPPLAEALLSGDLEKFSRVLVEQQQDRARREQERIRLFSADPFDLEAQAKIEEDIRQQNIEENMTIAMEEAPESFGQVVMLYINCKVNGHPVKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGIAKGVGTQKIIGRVHLAQVQIEGDFLPCSFSILEEQPMDMLLGLDMLKRHQCSIDLKKNVLVIGTTGSQTTFLPEGELPECARLAYGAGREDVRPEEIADQELAEALQKSAEDAERQKP
uniprot
proteins
ec_number
3.4.23.-
uniprot
proteins
function
FUNCTION: Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27528193, PubMed:27676298). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redundantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612). {ECO:0000269|PubMed:27528193, ECO:0000269|PubMed:27676298, ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}.
uniprot
proteins
mass_dalton
44523
uniprot
proteins
mutagenesis
MUTAGEN 252; /note="D->N: Abolishes aspartic protease activity."; /evidence="ECO:0000269|PubMed:27528193
uniprot
proteins
protein_family
DDI1 family
uniprot
proteins
pubmed
12838346
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27461074
uniprot
proteins
pubmed
27528193
uniprot
proteins
pubmed
27676298
uniprot
proteins
pubmed
29290612
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:27528193}. Chromosome {ECO:0000269|PubMed:29290612}.
uniprot
proteins