CLEC4D
entrez
338339
canonical
uniprot
Q8WXI8
canonical
ensembl
ENSG00000166527
resolver
ensp
ENSP00000299665
resolver
enst
ENST00000299665
resolver
genesymbol
CLEC4D
resolver
genesymbol_syn
CLECSF8
resolver
genesymbol_syn
MCL
resolver
hgnc
HGNC:14554
resolver
uniprot
Q8N5J5
resolver
uniprot_entry
CLC4D_HUMAN
resolver
uniprot_sec
Q8N5J5
resolver
amino_acid_sequence
MGLEKPQSKLEGGMHPQLIPSVIAVVFILLLSVCFIASCLVTHHNFSRCKRGTGVHKLEHHAKLKCIKEKSELKSAEGSTWNCCPIDWRAFQSNCYFPLTDNKTWAESERNCSGMGAHLMTISTEAEQNFIIQFLDRRLSYFLGLRDENAKGQWRWVDQTPFNPRRVFWHKNEPDNSQGENCVVLVYNQDKWAWNDVPCNFEASRICKIPGTTLN
uniprot
proteins
function
FUNCTION: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:23602766, PubMed:23911656). The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) (PubMed:23602766, PubMed:23911656). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766, PubMed:23911656). The heterodimer formed with CLEC6A is active against fungal infection (PubMed:23911656). Functions as an endocytic receptor (PubMed:14971047). May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (PubMed:14971047). {ECO:0000250|UniProtKB:Q69FH1, ECO:0000269|PubMed:14971047, ECO:0000269|PubMed:23602766, ECO:0000269|PubMed:23911656}.
uniprot
proteins
mass_dalton
24704
uniprot
proteins
mutagenesis
MUTAGEN 173; /note="E->Q: No effect on already low affinity binding to trehalose-6,6'-dimycolate."; /evidence="ECO:0000269|PubMed:24101491"; MUTAGEN 175; /note="D->N: No effect on already low affinity binding to trehalose-6,6'-dimycolate."; /evidence="ECO:0000269|PubMed:24101491
uniprot
proteins
pubmed
14971047
uniprot
proteins
pubmed
15368084
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23602766
uniprot
proteins
pubmed
23911656
uniprot
proteins
pubmed
24101491
uniprot
proteins
sequence_length
215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23911656}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins