Tmem41b
entrez
233724
canonical
uniprot
Q8K1A5
canonical
ensembl
ENSMUSG00000047554
resolver
ensp
ENSMUSP00000091641
resolver
ensp
ENSMUSP00000112574
resolver
genesymbol
Tmem41b
resolver
genesymbol_syn
D7Ertd743e
resolver
genesymbol_syn
Kiaa0033
resolver
uniprot
Q3TKT0
resolver
uniprot
Q3TLK6
resolver
uniprot
Q8C1X2
resolver
uniprot
Q8CBS5
resolver
uniprot
Q8CBU5
resolver
uniprot_entry
TM41B_MOUSE
resolver
uniprot_sec
Q3TKT0
resolver
uniprot_sec
Q3TLK6
resolver
uniprot_sec
Q8C1X2
resolver
uniprot_sec
Q8CBS5
resolver
uniprot_sec
Q8CBU5
resolver
amino_acid_sequence
MAKGRVADRSPTEMLHSTPAGDRAVRTQGSAAPGSKDHLNEKPCAEAGSARTSLLILVSIFSCAAFVMFLVYKNFPQLSEEERVNMKVPRDMDDAKALGKVLSKYKDTFYVQVLVAYFATYIFLQTFAIPGSIFLSILSGFLYPFPLALFLVCLCSGLGASFCYMLSYLVGRPVVYKYLTEKAVKWSQQVERHREHLINYIIFLRITPFLPNWFINITSPVINVPLKVFFIGTFLGVAPPSFVAIKAGTTLHQLTTAGEAVSWSSVFILMVLALLSILPAIFQKQLKQKFE
uniprot
proteins
function
FUNCTION: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity). Required for normal motor neuron development (By similarity). {ECO:0000250|UniProtKB:A1A5V7, ECO:0000250|UniProtKB:Q5BJD5}.
uniprot
proteins
mass_dalton
32429
uniprot
proteins
protein_family
TMEM41 family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23063131
uniprot
proteins
pubmed
30352685
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30352685}; Multi-pass membrane protein {ECO:0000255}. Endomembrane system {ECO:0000250|UniProtKB:Q5BJD5}. Note=Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. {ECO:0000269|PubMed:30352685}.
uniprot
proteins
transmembrane_region
TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 109..129; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 147..169; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 197..217; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 262..282; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins