Tbc1d5
entrez
72238
canonical
uniprot
Q80XQ2
canonical
ensembl
ENSMUSG00000023923
resolver
ensp
ENSMUSP00000024717
resolver
ensp
ENSMUSP00000153172
resolver
ensp
ENSMUSP00000219626
resolver
ensp
ENSMUSP00000219628
resolver
enst
ENSMUST00000024717
resolver
enst
ENSMUST00000224528
resolver
genesymbol
Tbc1d5
resolver
uniprot
A0A286YDB3
resolver
uniprot
E9PZJ9
resolver
uniprot
Q3UN43
resolver
uniprot_entry
A0A286YDB3_MOUSE
resolver
uniprot_entry
Q3UN43_MOUSE
resolver
uniprot_entry
TBCD5_MOUSE
resolver
uniprot_sec
E9PZJ9
resolver
amino_acid_sequence
MYKSVSETRHPLQSEEQEVGIDPLFSYSNKTRGDLSQNGRGSNSTLDTEGTFNSYMKEWEELFVNNNYLATVRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISKIKELRAWYSSIKEIHITNPRKAAGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIIFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLMAPIPFARPQDLGPTVAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADSLNLSLVDYVFTAMLLYIRDALISSNYQTCLGLLMHYPIIGDIHSLILKALFLRDPKRNPRPATYQFHPNLDYYKARGADLMNKSRTNARGAPLNIHKVSNSLINFGRKLISPASAPGSMGGPVPGNNSSSSFSAAIPTRTSTEAPRHHLLQQQQQQQHQQQQQQQPQQQQQQHQQQQQQQRLMKSESMPVQLNKGQSSKTISSSPSIESLPGGREFTGSPPPSATKKDSFFSNIARSRSHSKTMGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDMHLVNIQDVVLQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAGENEQITIADDHYCSSGQDQGSQVPRAAKQASSEMPGCTGGTTPDDFILVSKEDEGHRARGAFSGQAQPLLTLRSTSGKSRAPACSPLLFSDPLMGPASASASSSNPSSSPDDDSSKESGFTIVSPLDI
uniprot
proteins
function
FUNCTION: May act as a GTPase-activating protein for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (By similarity). {ECO:0000250|UniProtKB:Q92609}.
uniprot
proteins
mass_dalton
91837
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
815
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q92609}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q92609}. Note=During starvation induced autophagy is relocalized from endosomal localization to LC3-positive autophagosomes (By similarity). {ECO:0000250|UniProtKB:Q92609}.
uniprot
proteins