TOR1B
entrez
27348
canonical
uniprot
O14657
canonical
ensembl
ENSG00000136816
resolver
ensp
ENSP00000259339
resolver
ensp
ENSP00000411912
resolver
ensp
ENSP00000653457
resolver
ensp
ENSP00000789252
resolver
enst
ENST00000259339
resolver
genesymbol
TOR1B
resolver
genesymbol_syn
DQ1
resolver
hgnc
HGNC:11995
resolver
uniprot_entry
TOR1B_HUMAN
resolver
amino_acid_sequence
MLRAGWLRGAAALALLLAARVVAAFEPITVGLAIGAASAITGYLSYNDIYCRFAECCREERPLNASALKLDLEEKLFGQHLATEVIFKALTGFRNNKNPKKPLTLSLHGWAGTGKNFVSQIVAENLHPKGLKSNFVHLFVSTLHFPHEQKIKLYQDQLQKWIRGNVSACANSVFIFDEMDKLHPGIIDAIKPFLDYYEQVDGVSYRKAIFIFLSNAGGDLITKTALDFWRAGRKREDIQLKDLEPVLSVGVFNNKHSGLWHSGLIDKNLIDYFIPFLPLEYRHVKMCVRAEMRARGSAIDEDIVTRVAEEMTFFPRDEKIYSDKGCKTVQSRLDFH
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues. {ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}.
uniprot
proteins
mass_dalton
37979
uniprot
proteins
mutagenesis
MUTAGEN 178; /note="E->Q: Loss of ATPase activity. Produces sinusoidal endoplasmic reticulum structures where it accumulates. Highly enhances interaction with TOR1AIP2. Localizes in the nuclear envelope."; /evidence="ECO:0000269|PubMed:20015956, ECO:0000269|PubMed:24275647"; MUTAGEN 334..336; /note="DFH->GGG: Highly reduces ATPase activity induced by TOR1AIP2."; /evidence="ECO:0000269|PubMed:24275647"; MUTAGEN 334..336; /note="Missing: Decreases interaction with TOR1AIP2."; /evidence="ECO:0000269|PubMed:24275647"; MUTAGEN 335; /note="F->A: No effect on interaction with TOR1AIP2."; /evidence="ECO:0000269|PubMed:24275647
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:15147511}.
uniprot
proteins
protein_family
ClpA/ClpB family
uniprot
proteins
protein_family
Torsin subfamily
uniprot
proteins
pubmed
15147511
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20015956
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23569223
uniprot
proteins
pubmed
24275647
uniprot
proteins
pubmed
9288096
uniprot
proteins
sequence_length
336
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:15147511}. Nucleus membrane {ECO:0000269|PubMed:15147511}.
uniprot
proteins