Hcrtr1
entrez
230777
canonical
uniprot
P58307
canonical
ensembl
ENSMUSG00000028778
resolver
ensp
ENSMUSP00000030562
resolver
ensp
ENSMUSP00000112630
resolver
ensp
ENSMUSP00000113198
resolver
ensp
ENSMUSP00000127290
resolver
enst
ENSMUST00000030562
resolver
enst
ENSMUST00000119423
resolver
enst
ENSMUST00000120154
resolver
enst
ENSMUST00000164887
resolver
genesymbol
Hcrtr1
resolver
uniprot
Q0VDP5
resolver
uniprot
Q0VDP6
resolver
uniprot
Q3USS9
resolver
uniprot
Q6VNS3
resolver
uniprot
Q80T45
resolver
uniprot_entry
OX1R_MOUSE
resolver
uniprot_entry
Q0VDP6_MOUSE
resolver
uniprot_sec
Q0VDP5
resolver
uniprot_sec
Q3USS9
resolver
uniprot_sec
Q6VNS3
resolver
uniprot_sec
Q80T45
resolver
amino_acid_sequence
MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGQALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDEHWADELYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPGSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that binds the neuropeptide orexin-A with high affinity, and orexin-B with lower affinity, two peptides derived from a common precursor, prepro-orexin. Its activity is mediated via a G(q)-protein-coupled pathway, which activates the phosphatidylinositol-calcium second messenger system in response to orexin-A binding. In addition to G(q)-mediated signaling, orexin-A stimulation also promotes beta-arrestin recruitment, leading to receptor internalization (By similarity). Plays a significant role in the regulation of food intake (By similarity). {ECO:0000250|UniProtKB:O43613, ECO:0000250|UniProtKB:P56718}.
uniprot
proteins
mass_dalton
46781
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
15256537
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O43613}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O43613}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..67; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O43613"; TRANSMEM 83..105; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O43613"; TRANSMEM 120..140; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 161..182; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O43613"; TRANSMEM 214..235; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O43613"; TRANSMEM 299..321; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O43613"; TRANSMEM 337..360; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:O43613
uniprot
proteins