CCKBR
entrez
887
canonical
uniprot
P32239
canonical
ensembl
ENSG00000110148
resolver
ensp
ENSP00000335544
resolver
ensp
ENSP00000432079
resolver
ensp
ENSP00000435534
resolver
enst
ENST00000532715
resolver
genesymbol
CCKBR
resolver
genesymbol_syn
CCKRB
resolver
hgnc
HGNC:1571
resolver
uniprot
A8K7P9
resolver
uniprot
E9PIC8
resolver
uniprot
O75824
resolver
uniprot
Q16144
resolver
uniprot
Q92492
resolver
uniprot
Q96LC6
resolver
uniprot
Q9NYK7
resolver
uniprot
Q9UBV1
resolver
uniprot_entry
E9PIC8_HUMAN
resolver
uniprot_entry
GASR_HUMAN
resolver
uniprot_sec
A8K7P9
resolver
uniprot_sec
O75824
resolver
uniprot_sec
Q16144
resolver
uniprot_sec
Q92492
resolver
uniprot_sec
Q96LC6
resolver
uniprot_sec
Q9NYK7
resolver
uniprot_sec
Q9UBV1
resolver
amino_acid_sequence
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
uniprot
proteins
function
FUNCTION: Receptor for the peptide hormones gastrin and cholecystokinin (CCK). Expressed throughout the central nervous system, where it modulates processes such as anxiety, analgesia, arousal and neuroleptic activity. Couples to both GNAI1 and GNAQ signaling pathways, but not to GNAS (PubMed:34556863). Upon gastrin activation, reduces glucose absorption in intestinal epithelial cells by down-regulating SGLT1 and GLUT2 expression through suppression of the PI3K/Akt/eIF4B pathway (By similarity). In the kidney, decreases SGLT2 expression under high-glucose conditions via ERK/NF-kappa-B signaling (By similarity). {ECO:0000250|UniProtKB:P56481, ECO:0000269|PubMed:34556863, ECO:0000269|PubMed:35672283}.; FUNCTION: Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.
uniprot
proteins
mass_dalton
48419
uniprot
proteins
mutagenesis
MUTAGEN 324; /note="K->N: Three-fold increase of the coupling potency with GNAS."; /evidence="ECO:0000269|PubMed:35672283
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10913157
uniprot
proteins
pubmed
11495676
uniprot
proteins
pubmed
11926817
uniprot
proteins
pubmed
12429993
uniprot
proteins
pubmed
1280419
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
34556863
uniprot
proteins
pubmed
35672283
uniprot
proteins
pubmed
7681836
uniprot
proteins
pubmed
7848914
uniprot
proteins
pubmed
7887934
uniprot
proteins
pubmed
8185170
uniprot
proteins
pubmed
8221657
uniprot
proteins
pubmed
8222757
uniprot
proteins
pubmed
8349705
uniprot
proteins
pubmed
8415658
uniprot
proteins
pubmed
9872672
uniprot
proteins
sequence_length
447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 56..79; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:34556863"; TRANSMEM 91..109; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:34556863"; TRANSMEM 129..149; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:34556863"; TRANSMEM 172..189; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:34556863"; TRANSMEM 217..237; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:34556863"; TRANSMEM 334..353; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:34556863"; TRANSMEM 374..392; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:34556863
uniprot
proteins