F7
entrez
2155
canonical
uniprot
P08709
canonical
ensembl
ENSG00000057593
resolver
ensp
ENSP00000329546
resolver
ensp
ENSP00000364731
resolver
ensp
ENSP00000442051
resolver
ensp
ENSP00000561298
resolver
ensp
ENSP00000561299
resolver
ensp
ENSP00000561303
resolver
ensp
ENSP00000561312
resolver
enst
ENST00000541084
resolver
genesymbol
F7
resolver
hgnc
HGNC:3544
resolver
uniprot
B0YJC8
resolver
uniprot
B4DPM2
resolver
uniprot
F5H8B0
resolver
uniprot
Q14339
resolver
uniprot
Q5JVF1
resolver
uniprot
Q5JVF2
resolver
uniprot
Q9UD52
resolver
uniprot
Q9UD53
resolver
uniprot
Q9UD54
resolver
uniprot_entry
B4DPM2_HUMAN
resolver
uniprot_entry
F5H8B0_HUMAN
resolver
uniprot_entry
FA7_HUMAN
resolver
uniprot_sec
B0YJC8
resolver
uniprot_sec
Q14339
resolver
uniprot_sec
Q5JVF1
resolver
uniprot_sec
Q5JVF2
resolver
uniprot_sec
Q9UD52
resolver
uniprot_sec
Q9UD53
resolver
uniprot_sec
Q9UD54
resolver
amino_acid_sequence
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
uniprot
proteins
disease_involvement
DISEASE: Factor VII deficiency (FA7D) [MIM:227500]: A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. {ECO:0000269|PubMed:10862079, ECO:0000269|PubMed:11091194, ECO:0000269|PubMed:11129332, ECO:0000269|PubMed:12472587, ECO:0000269|PubMed:14717781, ECO:0000269|PubMed:1634227, ECO:0000269|PubMed:18976247, ECO:0000269|PubMed:19432927, ECO:0000269|PubMed:19751712, ECO:0000269|PubMed:2070047, ECO:0000269|PubMed:21206266, ECO:0000269|PubMed:21372693, ECO:0000269|PubMed:26761581, ECO:0000269|PubMed:36951360, ECO:0000269|PubMed:7974346, ECO:0000269|PubMed:7981691, ECO:0000269|PubMed:8043443, ECO:0000269|PubMed:8204879, ECO:0000269|PubMed:8242057, ECO:0000269|PubMed:8244334, ECO:0000269|PubMed:8364544, ECO:0000269|PubMed:8652821, ECO:0000269|PubMed:8844208, ECO:0000269|PubMed:8883260, ECO:0000269|PubMed:8940045, ECO:0000269|PubMed:9414278, ECO:0000269|PubMed:9452082, ECO:0000269|PubMed:9576180}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.21.21
uniprot
proteins
function
FUNCTION: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium (PubMed:271951). {ECO:0000269|PubMed:271951}.
uniprot
proteins
mass_dalton
51594
uniprot
proteins
mutagenesis
MUTAGEN 112; /note="S->A: Complete loss of O-glycosylation and O-xylosylation by POGLUT1."; /evidence="ECO:0000269|PubMed:21949356"; MUTAGEN 113; /note="S->A: No effect on O-glycosylation by POGLUT1. Drastic decrease in O-xylosylation."; /evidence="ECO:0000269|PubMed:21949356
uniprot
proteins
post_translational_modification
PTM: The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.; PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. {ECO:0000269|PubMed:3264725}.; PTM: O- and N-glycosylated. N-glycosylation at Asn-205 occurs cotranslationally and is mediated by STT3A-containing complexes, while glycosylation at Asn-382 is post-translational and is mediated STT3B-containing complexes before folding. O-fucosylated by POFUT1 on a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. {ECO:0000269|PubMed:1904059, ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:21949356, ECO:0000269|PubMed:3264725, ECO:0000269|PubMed:9023546}.; PTM: Can be either O-glucosylated or O-xylosylated at Ser-112 by POGLUT1 in vitro.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
10862079
uniprot
proteins
pubmed
10984565
uniprot
proteins
pubmed
11091194
uniprot
proteins
pubmed
11129332
uniprot
proteins
pubmed
12472587
uniprot
proteins
pubmed
14717781
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16292673
uniprot
proteins
pubmed
1634227
uniprot
proteins
pubmed
18976247
uniprot
proteins
pubmed
1904059
uniprot
proteins
pubmed
19167329
uniprot
proteins
pubmed
19432927
uniprot
proteins
pubmed
19751712
uniprot
proteins
pubmed
2070047
uniprot
proteins
pubmed
21206266
uniprot
proteins
pubmed
2129367
uniprot
proteins
pubmed
21372693
uniprot
proteins
pubmed
21949356
uniprot
proteins
pubmed
2511201
uniprot
proteins
pubmed
26761581
uniprot
proteins
pubmed
271951
uniprot
proteins
pubmed
3037537
uniprot
proteins
pubmed
3264725
uniprot
proteins
pubmed
34502392
uniprot
proteins
pubmed
3486420
uniprot
proteins
pubmed
36951360
uniprot
proteins
pubmed
7860081
uniprot
proteins
pubmed
7974346
uniprot
proteins
pubmed
7981691
uniprot
proteins
pubmed
8043443
uniprot
proteins
pubmed
8204879
uniprot
proteins
pubmed
8242057
uniprot
proteins
pubmed
8244334
uniprot
proteins
pubmed
8364544
uniprot
proteins
pubmed
8598903
uniprot
proteins
pubmed
8652821
uniprot
proteins
pubmed
8844208
uniprot
proteins
pubmed
8883260
uniprot
proteins
pubmed
8940045
uniprot
proteins
pubmed
9023546
uniprot
proteins
pubmed
9414278
uniprot
proteins
pubmed
9452082
uniprot
proteins
pubmed
9576180
uniprot
proteins
pubmed
9692950
uniprot
proteins
pubmed
9925787
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:36951360}.
uniprot
proteins