Itgb3bp
entrez
362548
canonical
uniprot
Q5U1Z7
canonical
ensembl
ENSRNOG00000009116
resolver
ensembl
ENSRNOG00055006911
resolver
ensembl
ENSRNOG00060023549
resolver
ensembl
ENSRNOG00065017581
resolver
ensp
ENSRNOP00000012947
resolver
ensp
ENSRNOP00000094591
resolver
ensp
ENSRNOP00000100095
resolver
ensp
ENSRNOP00000101174
resolver
ensp
ENSRNOP00055008961
resolver
ensp
ENSRNOP00060033860
resolver
ensp
ENSRNOP00065023383
resolver
enst
ENSRNOT00000103428
resolver
enst
ENSRNOT00000135761
resolver
enst
ENSRNOT00000144538
resolver
enst
ENSRNOT00055011393
resolver
enst
ENSRNOT00060040925
resolver
enst
ENSRNOT00065029455
resolver
genesymbol
Itgb3bp
resolver
genesymbol_syn
Cenpr
resolver
genesymbol_syn
Nrif3
resolver
uniprot
A0A8I6ARY4
resolver
uniprot
A0ABK0L009
resolver
uniprot
A0ABK0L5X3
resolver
uniprot_entry
A0A8I6ARY4_RAT
resolver
uniprot_entry
A0ABK0L009_RAT
resolver
uniprot_entry
A0ABK0L5X3_RAT
resolver
uniprot_entry
CENPR_RAT
resolver
amino_acid_sequence
MPVKRSLKLDDQFEENSFGPSKIMRKKSITAFSPTTGTYQLSPFSSPRTPKEQEHRDGPSNGTRKWSVLSSPARQDSTVKGSDGFMMLLSKIERSSEKTMEIMKNLSSLQALEGNRQLEDLLGVSLVPCSLKSEAKKTKELMTKVMKQKLFEKKNSRIPPKEHHPNSFEFLKAILN
uniprot
proteins
function
FUNCTION: Transcription coregulator that can have both coactivator and corepressor functions. Involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
19917
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
176
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}.
uniprot
proteins