Faf2
entrez
291000
canonical
uniprot
Q5BK32
canonical
ensembl
ENSRNOG00000017607
resolver
ensembl
ENSRNOG00055014139
resolver
ensembl
ENSRNOG00060016947
resolver
ensembl
ENSRNOG00065022453
resolver
ensp
ENSRNOP00000063246
resolver
ensp
ENSRNOP00000068627
resolver
ensp
ENSRNOP00000080533
resolver
ensp
ENSRNOP00000086396
resolver
ensp
ENSRNOP00055019852
resolver
ensp
ENSRNOP00060023384
resolver
ensp
ENSRNOP00065031016
resolver
enst
ENSRNOT00000064477
resolver
enst
ENSRNOT00000091837
resolver
enst
ENSRNOT00000095037
resolver
enst
ENSRNOT00000096763
resolver
enst
ENSRNOT00055024303
resolver
enst
ENSRNOT00060029040
resolver
enst
ENSRNOT00065038304
resolver
genesymbol
Faf2
resolver
genesymbol_syn
Ubxd8
resolver
uniprot
A0A0G2JTA0
resolver
uniprot
A0A8I5ZPX1
resolver
uniprot
A0A8I6A8N6
resolver
uniprot_entry
A0A0G2JTA0_RAT
resolver
uniprot_entry
A0A8I5ZPX1_RAT
resolver
uniprot_entry
A0A8I6A8N6_RAT
resolver
uniprot_entry
FAF2_RAT
resolver
amino_acid_sequence
MLPFRFTYYTILDIFRFALRFIRPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYSQALSDAKRELRFLLVYLHGDDHQDSDEFCRNALCAPEVISLINSRMLFWACSTNKPEGYRVSQALRENTYPFLAMIMLKDRRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSERLEREERNQTQVLRQQQDEAYLASLRADQEKERKKREERERKRRKEEEVQQQKLAEERRRQNLQEEKERKLECLPPEPSPDDPDSVKIIFKLPNDSRVERRFHFSQSLTVIHDFLFSLKESPEKFQIEANFPRRVLPCVPSEEWPNPPTLQEAGLSHTEVLFVQDLTDE
uniprot
proteins
function
FUNCTION: Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Recruits ATPase VCP to lipid droplets and also binds to phospholipase PNPLA2/ATGL, inhibiting PNPLA2 activity by promoting its dissociation from its ABHD5/CGI-58 activator. This inhibits PNPLA2-mediated triacylglycerol hydrolysis and leads to inhibition of lipid droplet degradation. Involved in stress granule disassembly: associates with ubiquitinated G3BP1 in response to heat shock, thereby promoting interaction between ubiquitinated G3BP1 and VCP, followed by G3BP1 extraction from stress granules and stress granule disassembly. {ECO:0000250|UniProtKB:Q96CS3}.
uniprot
proteins
mass_dalton
41080
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96CS3}. Lipid droplet {ECO:0000250|UniProtKB:Q96CS3}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q96CS3}.
uniprot
proteins