Slc13a2
entrez
65202
canonical
uniprot
P70545
canonical
ensembl
ENSRNOG00000010337
resolver
ensembl
ENSRNOG00055024952
resolver
ensembl
ENSRNOG00060018251
resolver
ensembl
ENSRNOG00065023152
resolver
ensp
ENSRNOP00000038185
resolver
ensp
ENSRNOP00055035101
resolver
ensp
ENSRNOP00060025399
resolver
ensp
ENSRNOP00065032152
resolver
enst
ENSRNOT00000038690
resolver
enst
ENSRNOT00055043011
resolver
enst
ENSRNOT00060031303
resolver
enst
ENSRNOT00065039548
resolver
genesymbol
Slc13a2
resolver
genesymbol_syn
Nadc1
resolver
genesymbol_syn
Sdct1
resolver
uniprot
O35055
resolver
uniprot_entry
S13A2_RAT
resolver
uniprot_sec
O35055
resolver
activity_regulation
ACTIVITY REGULATION: Li(+) decreases succinate transport in the presence of Na(+), by competing at one of the three cation binding sites (PubMed:9694847). Citrate transport is inhibited by N-(p-amylcinnamoyl) anthranilic acid (ACA) (By similarity). {ECO:0000250|UniProtKB:Q13183, ECO:0000269|PubMed:9694847}.
uniprot
proteins
amino_acid_sequence
MATCWPALWAYRFYLIVLCLPIFLLPLPLIVQTKEAYCAYSIILMALLWCTEALPLAVTALFPIVLFPLMGIMDASEVCIEYFKDTNILFVGGLMVAIAVEHWNLHKRIALQVLLIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMVPIGHAVLEQLQGSKKDVEGGNNNPTFELQEECPQKEVTKLDNGQPVSAPSEPRTQKTQEHHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSLFPQNGNVVNFASWFGFAFPTMIILLLLAWLWLQVLFLGVNFRKNFGFGEGEEERKQAAFQVIKTQYRLLGPMSFAEKTVTVLFVLLVVLWFTREPGFFPGWGDTVFANEKGQSMASDGTVAIFISLVMFIIPSKIPGLMQDPKKPGKLKAPPAILTWKTVNDKMPWNIVILLGGGFALAKGSEQSGLSEWLGDKLTPLQHIPPSATAVILCLLIAIFTECTSNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLAFMLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLAITLSINSWSIPIFKLDTFPSWAHSNTSQCLLNPSNSTVPGGL
uniprot
proteins
function
FUNCTION: Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (PubMed:9691021, PubMed:9694847). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:9691021, PubMed:9694847). Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood (PubMed:9694847). Has a critical role in renal dicarboxylate transport (By similarity). {ECO:0000250|UniProtKB:Q9ES88, ECO:0000269|PubMed:9691021, ECO:0000269|PubMed:9694847}.
uniprot
proteins
mass_dalton
64143
uniprot
proteins
protein_family
NADC subfamily
uniprot
proteins
protein_family
SLC13A/DASS transporter (TC 2.A.47) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
8950177
uniprot
proteins
pubmed
9691021
uniprot
proteins
pubmed
9694847
uniprot
proteins
sequence_length
587
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:9691021}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..28; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 37..53; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 55..69; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 75..96; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 125..138; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 140..151; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 214..230; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 265..282; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 326..342; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 363..378; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 412..428; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 502..521; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 526..548; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183
uniprot
proteins