RNF126
entrez
55658
canonical
uniprot
Q9BV68
canonical
ensembl
ENSG00000070423
resolver
ensp
ENSP00000292363
resolver
ensp
ENSP00000464945
resolver
ensp
ENSP00000668549
resolver
enst
ENST00000292363
resolver
genesymbol
RNF126
resolver
hgnc
HGNC:21151
resolver
uniprot
A8K0Q1
resolver
uniprot
Q9NWX1
resolver
uniprot_entry
A8K0Q1_HUMAN
resolver
uniprot_entry
RN126_HUMAN
resolver
uniprot_sec
Q9NWX1
resolver
amino_acid_sequence
MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGSAPSTAPTDQSRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPESRRERDHPSRHRYGARQPRARLTTRRATGRHEGVPTLEGIIQQLVNGIITPATIPSLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSSSSPSNENATSNS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (PubMed:23277564, PubMed:24275455, PubMed:24981174, PubMed:36563124). Depending on the associated E2 ligase, mediates 'Lys-27'-, 'Lys-29'-, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates (PubMed:36563124). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (PubMed:24981174, PubMed:29042515). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination (PubMed:23418353). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564). Acts as a regulator of DNA repair by mediating 'Lys-27'- and 'Lys-29'-linked polyubiquitination of MRE11, thereby promoting the exonuclease activity of MRE11 (PubMed:36563124). {ECO:0000269|PubMed:23277564, ECO:0000269|PubMed:23418353, ECO:0000269|PubMed:24275455, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:29042515, ECO:0000269|PubMed:36563124, ECO:0000305|PubMed:23026136}.
uniprot
proteins
mass_dalton
33861
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="H->A: Impaired interaction with BAG6."; /evidence="ECO:0000269|PubMed:27193484"; MUTAGEN 36; /note="F->A: Impaired interaction with BAG6."; /evidence="ECO:0000269|PubMed:27193484"; MUTAGEN 38..39; /note="EE->RR: Impaired interaction with BAG6."; /evidence="ECO:0000269|PubMed:27193484"; MUTAGEN 229..232; /note="CPVC->APVA: Loss of E3 ligase activity."; /evidence="ECO:0000269|PubMed:23026136, ECO:0000269|PubMed:36563124
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:23026136, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:36563124}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. May undergo autoubiquitination. {ECO:0000269|PubMed:23026136}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23026136
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23277564
uniprot
proteins
pubmed
23418353
uniprot
proteins
pubmed
24275455
uniprot
proteins
pubmed
24981174
uniprot
proteins
pubmed
27193484
uniprot
proteins
pubmed
29042515
uniprot
proteins
pubmed
36563124
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23026136}. Nucleus {ECO:0000269|PubMed:23026136}.
uniprot
proteins