EPX
entrez
8288
canonical
uniprot
P11678
canonical
ensembl
ENSG00000121053
resolver
ensp
ENSP00000225371
resolver
enst
ENST00000225371
resolver
genesymbol
EPX
resolver
genesymbol_syn
EPER
resolver
genesymbol_syn
EPO
resolver
genesymbol_syn
EPP
resolver
hgnc
HGNC:3423
resolver
uniprot
Q4TVP3
resolver
uniprot_entry
PERE_HUMAN
resolver
uniprot_sec
Q4TVP3
resolver
amino_acid_sequence
MHLLPALAGVLATLVLAQPCEGTDPASPGAVETSVLRDCIAEAKLLVDAAYNWTQKSIKQRLRSGSASPMDLLSYFKQPVAATRTVVRAADYMHVALGLLEEKLQPQRSGPFNVTDVLTEPQLRLLSQASGCALRDQAERCSDKYRTITGRCNNKRRPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVRAVSNQIVRFPNERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAGVDCERTCAQLPPCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRVRNQINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGKARARRTLGHYRGYCSNVDPRVANVFTLAFRFGHTMLQPFMFRLDSQYRASAPNSHVPLSSAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVRRIGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLNLYGTPDNIDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQKRGVFTKRQRKALSRISLSRIICDNTGITTVSRDIFRANIYPRGFVNCSRIPRLNLSAWRGT
uniprot
proteins
disease_involvement
DISEASE: Eosinophil peroxidase deficiency (EPXD) [MIM:261500]: A rare abnormality without clinical symptoms characterized by decreased or absent peroxidase activity and decreased volume of the granule matrix in eosinophils. {ECO:0000269|PubMed:7809065}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.11.1.7
uniprot
proteins
function
FUNCTION: Heme-containing oxidoreductase that catalyzes the oxidation of small anions, such as nitrite, halides (e.g bromide and chloride (at pH 6.5)) and pseudohalides (e.g thiocyanate) by using hydrogen peroxide to generate the corresponding reactive species hypobromite, hypochlorite, hypothiocyanous acid, and nitrogen dioxide (PubMed:11013238, PubMed:11112545, PubMed:12540536, PubMed:7852368). Also oxidizes thiocyanate (SCN(-)) to cyanate (OCN(-)) (PubMed:11112545). Functionally involved in inflammatory responses and exhibits antimicrobial activity (PubMed:12540536, PubMed:27587397). Can also oxidize amino acid residues on proteins and generate bromination, nitration and carbamoylation post-translational modifications, respectively (PubMed:18694936, PubMed:27587397). Mediates the nitration of tyrosine (3-nitrotyrosine) which is only observed in secondary granule proteins in mature resting eosinophils in the presence of the cosubstrates, hydrogen peroxide and nitrite (PubMed:18694936). Mediates oxidation of tyrosine residues on proteins in eosinophils to form brominating species, 3-bromotyrosine and 3, 5-dibromotyrosine in the presence of hydrogen peroxide and bromide (By similarity). Promotes protein carbamoylation at sites of inflammation during asthma by using thiocyanate and hydrogen peroxide to form cyanate which carbamoylates lysine residues to form homocitrulline (PubMed:27587397). {ECO:0000250|UniProtKB:P80550, ECO:0000269|PubMed:11013238, ECO:0000269|PubMed:11112545, ECO:0000269|PubMed:12540536, ECO:0000269|PubMed:18694936, ECO:0000269|PubMed:27587397, ECO:0000269|PubMed:7852368}.
uniprot
proteins
mass_dalton
81040
uniprot
proteins
protein_family
Peroxidase family
uniprot
proteins
protein_family
XPO subfamily
uniprot
proteins
pubmed
10358043
uniprot
proteins
pubmed
11013238
uniprot
proteins
pubmed
11112545
uniprot
proteins
pubmed
12540536
uniprot
proteins
pubmed
14657871
uniprot
proteins
pubmed
18694936
uniprot
proteins
pubmed
2541222
uniprot
proteins
pubmed
2550461
uniprot
proteins
pubmed
27587397
uniprot
proteins
pubmed
38229400
uniprot
proteins
pubmed
7809065
uniprot
proteins
pubmed
7852368
uniprot
proteins
sequence_length
715
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000269|PubMed:2541222}. Note=Cytoplasmic granules of eosinophils. {ECO:0000269|PubMed:2541222}.
uniprot
proteins