Trim10
entrez
19824
canonical
uniprot
Q9WUH5
canonical
ensembl
ENSMUSG00000073400
resolver
ensp
ENSMUSP00000057928
resolver
ensp
ENSMUSP00000213712
resolver
ensp
ENSMUSP00000213713
resolver
ensp
ENSMUSP00000359729
resolver
enst
ENSMUST00000060524
resolver
genesymbol
Trim10
resolver
genesymbol_syn
Herf1
resolver
genesymbol_syn
Rnf9
resolver
uniprot
Q80WA9
resolver
uniprot
Q9CY03
resolver
uniprot_entry
TRI10_MOUSE
resolver
uniprot_sec
Q80WA9
resolver
uniprot_sec
Q9CY03
resolver
amino_acid_sequence
MASAPSVTSLADEVNCPICQGTLREPVTIDCGHNFCRGCLTRYCEIPGPESEESLSCPLCKEPFRPGSFRPNWQLANVVENIERLQLASTRGLEVEDACPEHGEKIYFFCEEDEAQLCVVCRETGQHGAHTVRFLEDAAGPYREQIQKCLVCLRKEREEIQETQSRENKRIQVLLTQVATKRQQVISQFAHLSQFLQQQQTALLAQLEGLDGDILKQQEEFDSLATGEICRFSTLIEELEEKNKRTARGLLTDIRSTLIRCETRKCRKPEAISPELGQRIRDFPQQAIPLRQEMKTFLEKLCFELDYEPAHISLDPQTSHPKLLLSEDHRRARFSYKWQNSPDTPQRFDRVTCVLAQCGFTGGRHTWMVNVDLAHGGSCTVGVVREDVRRKGELRLRPEEGIWAVRLAWGFVSALGSFPTRLALEEQPRKVQVSLDYEVGWITFVNAVTQEHIYTFTASFTQKIFPLFGLWGRGSSFSLSCQEGAVSLL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells (PubMed:18560381). May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (PubMed:32343488). Acts as a positive regulator of cGAS-STING signaling by mediating 'Lys-27'- and 'Lys-29'-linked polyubiquitination of STING1, promoting STING1 activation (By similarity). In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (By similarity). {ECO:0000250|UniProtKB:Q9UDY6, ECO:0000269|PubMed:18560381, ECO:0000269|PubMed:32343488}.
uniprot
proteins
mass_dalton
55630
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9UDY6}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
10207104
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18560381
uniprot
proteins
pubmed
32343488
uniprot
proteins
sequence_length
489
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UDY6}.
uniprot
proteins