Gramd1c
entrez
207798
canonical
uniprot
Q8CI52
canonical
ensembl
ENSMUSG00000036292
resolver
ensp
ENSMUSP00000036739
resolver
ensp
ENSMUSP00000110325
resolver
ensp
ENSMUSP00000137426
resolver
ensp
ENSMUSP00000150056
resolver
enst
ENSMUST00000036174
resolver
enst
ENSMUST00000114677
resolver
enst
ENSMUST00000179565
resolver
enst
ENSMUST00000214098
resolver
genesymbol
Gramd1c
resolver
uniprot
A0A1L1SSU1
resolver
uniprot
A0A3P9AQ15
resolver
uniprot
Q8BI24
resolver
uniprot_entry
A0A3P9AQ15_MOUSE
resolver
uniprot_entry
ASTRC_MOUSE
resolver
uniprot_sec
A0A1L1SSU1
resolver
uniprot_sec
Q8BI24
resolver
amino_acid_sequence
MEGALTARQIVNEGDSSLATELQEEPEESPGPVVDENIVSAKKQGQSTHNWSGDWSFWISSSTYKDRNEEYRQQFTHLPDSEKLIADYACALQKDILVQGRLYLSEKWLCFYSNIFRWETTISIALKNITFMTKEKTARLIPNAIQIITEGEKFFFTSFGARDRSYLIIFRLWQNVLLDKSLTRQEFWQLLQQNYGTELGLNAEEMEHLLSVEENVQPRSPGRSSVDDAGERDEKFSKAVSFTQESVSRASETEPLDGNSPKRGLGKEDSQSERNVRKSPSLASEKRISRAPSKSLDLNKNEYLSLDKSSTSDSVDEENIPEKDLQGRLYINRVFHISAERMFELLFTSSHFMQRFANSRNIIDVVSTPWTVESGGNQLRTMTYTIVLSNPLTGKYTAATEKQTLYKESREAQFYLVDSEVLTHDVPYHDYFYTLNRYCIVRSAKQRCRLRVSTDLKYRKQPWGLIKSLIEKNSWSSLESYFKKLESDLLMEESVLSQSIEDAGKHSSLRRRRRTLNRTAEPVPKLSSQRSSTDLGFEAKVDVTGKRKTVDSYDTALIVVMSIFLLLLVLLNVTLFLKLSKIEHATQSFYQLHLQGEKSLNLVSDRFSRTENIQKNKDQAHRLKGVLQDSIVMLEQLKSSLIMLQKTFDLLNKNKSGVAVES
uniprot
proteins
function
FUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (PubMed:30220461). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (PubMed:30220461). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (PubMed:30220461). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (PubMed:30220461). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (PubMed:30220461). {ECO:0000269|PubMed:30220461}.
uniprot
proteins
mass_dalton
76009
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
30220461
uniprot
proteins
sequence_length
662
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30220461}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30220461}; Single-pass membrane protein {ECO:0000255}. Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS). {ECO:0000269|PubMed:30220461}.
uniprot
proteins
transmembrane_region
TRANSMEM 557..577; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins