Clec12b
entrez
71183
canonical
uniprot
Q149M0
canonical
ensembl
ENSMUSG00000030158
resolver
ensp
ENSMUSP00000032261
resolver
ensp
ENSMUSP00000107713
resolver
enst
ENSMUST00000032261
resolver
enst
ENSMUST00000112082
resolver
genesymbol
Clec12b
resolver
uniprot
A0A0R4J0A7
resolver
uniprot
Q9D403
resolver
uniprot_entry
A0A0R4J0A7_MOUSE
resolver
uniprot_entry
CL12B_MOUSE
resolver
uniprot_sec
Q9D403
resolver
amino_acid_sequence
MSDEVTYATLMLQDSARVRGNQDGNNLRKEGHPAQSSLWRGAALSLMTLCLVLVTGLVTLATMFLQVSNDINSDSEKLSQLQKSIHPQQDNLSESLNSSRKSLTEESLQSQISALLERQEQMATKLCKEFLIHASDHKCNPCPKTWQWYGNSCYYFSINEEKSWSDSRKDCIDKNATLVKIDSTEERDLLQSQLSLTFSFFWLGLSWNSSGRNWLWEDGSFPPPTLFSDKELASFNGSRDCAYFERGNIYASRCSAEIPWICEKTASLVKTEDLD
uniprot
proteins
function
FUNCTION: Inhibitory receptor postulated to negatively regulate immune and non-immune functions (By similarity). Upon phosphorylation, recruits SH2 domain-containing PTPN6 and PTPN11 phosphatases to its ITIM motif and antagonizes activation signals (By similarity). Although it inhibits KLRK1/NKG2D-mediated signaling, it does not bind known ligands of KLRK1/NKG2D and therefore is not its inhibitory counterpart (By similarity). May limit activation of myeloid cell subsets in response to infection or tissue inflammation (By similarity). May protect target cells against natural killer cell-mediated lysis (By similarity). May negatively regulate cell cycle and differentiation of melanocytes via inactivation of STAT3 (By similarity). Plays an important function in the skin immunity by modulating melanocytes immune function through the phosphorylation of its ITIM domain. Mechanistically, senses exogenous ligands present on S. aureus and E. coli but not gut Listeria monocytogenes and modulates the IFNgamma-induced production of chemokines and subsequent chemoattraction of immune cells through the STAT1/IRF1/CXCL9 axis (By similarity). {ECO:0000250|UniProtKB:Q2HXU8}.
uniprot
proteins
mass_dalton
31186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2HXU8}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..64; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins