Eif6
entrez
16418
canonical
uniprot
O55135
canonical
ensembl
ENSMUSG00000027613
resolver
ensp
ENSMUSP00000029142
resolver
enst
ENSMUST00000029142
resolver
genesymbol
Eif6
resolver
genesymbol_syn
EIF6
resolver
genesymbol_syn
ITGB4BP
resolver
genesymbol_syn
Itgb4bp
resolver
uniprot
Q545K4
resolver
uniprot_entry
IF6_MOUSE
resolver
uniprot_entry
Q545K4_MOUSE
resolver
amino_acid_sequence
MAVRASFENNCEVGCFAKLTNAYCLVAIGGSENFYSVFEGELSDAIPVVHASIAGCRIIGRMCVGNRHGLLVPNNTTDQELQHIRNSLPDSVQIRRVEERLSALGNVTTCNDYVALVHPDLDRETEEILADVLKVEVFRQTVADQVLVGSYCVFSNQGGLVHPKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVVESVFKLNEAKPSTIATSMRDSLIDSLT
uniprot
proteins
function
FUNCTION: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR (PubMed:26383020). Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (PubMed:26391622). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (PubMed:21665150). {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:18784653, ECO:0000269|PubMed:21665150, ECO:0000269|PubMed:26383020, ECO:0000269|PubMed:26391622}.
uniprot
proteins
mass_dalton
26511
uniprot
proteins
mutagenesis
MUTAGEN 235; /note="S->A: Abolishes insulin-stimulated translation, abrogates tumorigenesis."; /evidence="ECO:0000269|PubMed:18784653, ECO:0000269|PubMed:21665150, ECO:0000269|PubMed:26383020
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export. {ECO:0000250|UniProtKB:P56537}.; PTM: Ufmylated by UFL1. {ECO:0000269|PubMed:28575669}.
uniprot
proteins
protein_family
EIF-6 family
uniprot
proteins
pubmed
10206977
uniprot
proteins
pubmed
11290417
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18784653
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21536732
uniprot
proteins
pubmed
21665150
uniprot
proteins
pubmed
26383020
uniprot
proteins
pubmed
26391622
uniprot
proteins
pubmed
28575669
uniprot
proteins
pubmed
9374518
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
uniprot
proteins