Syt10
entrez
60567
canonical
uniprot
O08625
canonical
ensembl
ENSRNOG00000014296
resolver
ensembl
ENSRNOG00055012196
resolver
ensembl
ENSRNOG00060025239
resolver
ensembl
ENSRNOG00065017388
resolver
ensp
ENSRNOP00000109467
resolver
ensp
ENSRNOP00055016728
resolver
ensp
ENSRNOP00060036279
resolver
ensp
ENSRNOP00065022994
resolver
enst
ENSRNOT00000172684
resolver
enst
ENSRNOT00055020742
resolver
enst
ENSRNOT00060043735
resolver
enst
ENSRNOT00065029030
resolver
genesymbol
Syt10
resolver
uniprot
Q925B8
resolver
uniprot_entry
SYT10_RAT
resolver
uniprot_sec
Q925B8
resolver
amino_acid_sequence
MSFRKEDGVSSLCQKALHIITELCFAGQVEWDKCSGIFPADRSGQGGGGTDISVSLLAVVVSFCGLALLVVSLFVFWKLCWPCWKSKLVAPNVSTLPQSISSAPTEVFETEEKKEVEENEKPAPKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQRQTTDPTSSSRHNSFRRHLPRQMNVSSVDFSMGTEPVLQRGETRTSIGRIKPELYKQKSVDSEGNRKDDVKTCGKLNFALQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKIYLLPDRKKKFQTRVHRKTLNPLFDELFQFPVVYDQLSNRKLHFSIYDFDRFSRHDMIGEVILDNLFEVSDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLCIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLAYHRKPITHWHPLLELPGRATSFDSQGSCSSPRPPSTP
uniprot
proteins
function
FUNCTION: Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (PubMed:18508778). {ECO:0000250|UniProtKB:Q9R0N4, ECO:0000269|PubMed:18508778}.
uniprot
proteins
mass_dalton
59011
uniprot
proteins
protein_family
Synaptotagmin family
uniprot
proteins
pubmed
11823420
uniprot
proteins
pubmed
18508778
uniprot
proteins
pubmed
9122248
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q9R0N4}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to neuronal vesicles containing IGF1 that are not enriched at synapses. Does not colocalize with synaptic vesicles or with the Golgi apparatus. {ECO:0000250|UniProtKB:Q9R0N4}.
uniprot
proteins
transmembrane_region
TRANSMEM 56..76; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins