Slc46a3
entrez
288454
canonical
uniprot
Q5BK75
canonical
ensembl
ENSRNOG00000000937
resolver
ensembl
ENSRNOG00055003731
resolver
ensembl
ENSRNOG00060002270
resolver
ensembl
ENSRNOG00065006708
resolver
ensp
ENSRNOP00000001243
resolver
ensp
ENSRNOP00000106055
resolver
ensp
ENSRNOP00055004417
resolver
ensp
ENSRNOP00060002452
resolver
ensp
ENSRNOP00065007618
resolver
enst
ENSRNOT00055005869
resolver
enst
ENSRNOT00060003563
resolver
enst
ENSRNOT00065010392
resolver
genesymbol
Slc46a3
resolver
uniprot_entry
S46A3_RAT
resolver
amino_acid_sequence
MKISFIEPAILLYAFAMTLTIPLTAQYVYRRIWEETGNYTFTSSSNVSECEQNKSSSTFAFQEEVQKKASLFSLQVEISGLIPGLVSTFMLLSSSDNHGRKLPMVLSSLGSLGTNLWLCAMSYFDLPLQLLVASTFIGALFGNYTTFWGACFAYIVDQEKEYKHRIIRIAVLDFMLGVVTGLTGLSSGYFIRELGFAWSYFIIAVVVLVNLAYILFFLSDPIKESSSQIVTMSCSESLKDLFYRTYMLFKNGSCKRRSLLCLLIFTLVVYFFVVFGITPVFTLYELGPPLCWNEVYIGYGSALGSLSFLSSFLGIWLFSYCLKDIHIAYVGIFTTMVGMMLTAFTRTTLMMFLVRISFFFTIMPLSILRSMLSKVVHSTEQGVLFACIAFLETLGGVTSTSAYNGIYSATVAWYPGFVFLLSAGLLVLPAVSLCMVKCIGWEEGSYTLLIHDEPSEHTSDS
uniprot
proteins
function
FUNCTION: Lysosomal proton-coupled steroid conjugate and bile acid transporter. Preferentially recognizes lipophilic steroid conjugates or bile acis as endogenous substrates and seems to mediate escape from lysosomes to the cytoplasm (By similarity). Modulates hepatic cytosolic copper homeostasis, maybe acting as a lysosomal copper transporter and sequestering copper ions in the lysosome (By similarity). Delivers pathogen-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes. Selectively transports bacterial muramyl dipeptide (MDP) into the cytosol for recognition by NOD2, triggering inflammatory responses (By similarity). Likely acts as a redundant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages. The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (By similarity). {ECO:0000250|UniProtKB:Q7Z3Q1, ECO:0000250|UniProtKB:Q9DC26}.
uniprot
proteins
mass_dalton
51527
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
SLC46A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q7Z3Q1}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 171..191; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 198..218; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 261..281; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 302..322; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 325..345; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 348..368; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 382..402; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 416..436; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins