Slc38a9
entrez
268706
canonical
uniprot
Q8BGD6
canonical
ensembl
ENSMUSG00000047789
resolver
ensp
ENSMUSP00000052172
resolver
ensp
ENSMUSP00000286819
resolver
ensp
ENSMUSP00000286828
resolver
enst
ENSMUST00000052514
resolver
genesymbol
Slc38a9
resolver
uniprot
Q80W70
resolver
uniprot
Q8C5C3
resolver
uniprot_entry
S38A9_MOUSE
resolver
uniprot_sec
Q80W70
resolver
uniprot_sec
Q8C5C3
resolver
amino_acid_sequence
MASVDGDSRHLLSEVEHEVSPGPMNIQFDSSDLRSKRPFYIEPTNIVNVNDVIQRVSDHAAAMNKRIHYYSRLTTPADKALIAPDHVVPAPEECYVYSPLGSAYKLKSYTEGYGKNTSLVTIFMIWNTMMGTSILSIPWGIKQAGFTTGMCVIVLMGLLTLYCCYRVVKSRSTISTSDTSTWEYPDVCKHYFGSFGQWSSLLFSLVSLIGAMIVYWVLMSNFLFNTGKFIFNFIHHINDTDTVLSTNNSNPVICPNAGSGGRPDNSSMIFYNNNTEVQLFEKWWDKSRTVPFYLIGLLLPLLNFKSPSFFSKFNILGTVSVLYLIFVVTLKAVRLGFHLEFHWFVPTEFFVPEIRAQFPQLMGVLTLAFFIHNCIITLLKNNKNQENNVRDLCIAYMLVTLTYLYIGILVFASFPSPPLPKDCIEQNFLDNFPSSDILSFIARIFLLFQMMTVYPLLGYLARVQLLGHIFGDIYPSIFHVLILNLVIVGAGVTMACFYPNIGGIIRYSGAACGLAFVFIYPSLIYIISLHQEERLTWPKLVFHVIIIILGLANLIAQFFM
uniprot
proteins
function
FUNCTION: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids. Acts as an arginine sensor. Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation. However, the transport mechanism is not well defined and the role of sodium is not clear. Can disassemble the lysosomal folliculin complex (LFC), and thereby triggers GAP activity of FLCN:FNIP2 toward RRAGC. Acts as an cholesterol sensor that conveys increases in lysosomal cholesterol, leading to lysosomal recruitment and activation of mTORC1 via the Rag GTPases. Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency. {ECO:0000250|UniProtKB:Q8NBW4}.
uniprot
proteins
mass_dalton
63392
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q8NBW4}.
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
protein_family
SLC38A9 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
sequence_length
560
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q8NBW4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q08BA4}. Late endosome membrane {ECO:0000250|UniProtKB:Q8NBW4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q08BA4}.
uniprot
proteins
transmembrane_region
TRANSMEM 119..139; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 146..166; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 198..224; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 283..299; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 309..333; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 356..376; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 394..414; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 437..457; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 479..499; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 507..527; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 540..560; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q08BA4
uniprot
proteins