Epha5
entrez
79208
canonical
uniprot
P54757
canonical
ensembl
ENSRNOG00000002024
resolver
ensp
ENSRNOP00000002793
resolver
ensp
ENSRNOP00000043926
resolver
ensp
ENSRNOP00000062326
resolver
ensp
ENSRNOP00000085420
resolver
enst
ENSRNOT00000002793
resolver
enst
ENSRNOT00000043938
resolver
enst
ENSRNOT00000067439
resolver
enst
ENSRNOT00000100109
resolver
genesymbol
Epha5
resolver
genesymbol_syn
Ehk-1
resolver
genesymbol_syn
Ekh1
resolver
genesymbol_syn
Rek7
resolver
uniprot
A0A8I6A019
resolver
uniprot
D3ZBZ7
resolver
uniprot
D3ZCV9
resolver
uniprot
F1M7W0
resolver
uniprot_entry
A0A8I6A019_RAT
resolver
uniprot_entry
D3ZBZ7_RAT
resolver
uniprot_entry
D3ZCV9_RAT
resolver
uniprot_entry
EPHA5_RAT
resolver
uniprot_entry
F1M7W0_RAT
resolver
amino_acid_sequence
MRGSGPRGAGRRRTQGRGGGGDTPRVPASLAGCYSAPLKGPLWTCLLLCAALRTLLASPSNEVNLLDSRTVLGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDDENGRNIKDNQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVSGSCVNHSVTDDPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQVCRPGFFKASPHSQTCSKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSAPRNAISNVNETSVFLEWIPPADTGGGKDVSYYILCKKCNSHAGVCEECGGHVRYLPQQIGLKNTSVMMADPLAHTNYTFEIEAVNGVSDLSPGTRQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETTITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVFGASNDQSQIPIIGVSVTVGVILLAVMIGFLLSGSCCECGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPTQAVHEFGKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVATKTLKVGYTEKQRRDFLSEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFDDIVNMLDKLIRNPSSLKTLVNASSRVSTLLAEHGSLGSGAYRSVGEWLEATKMGRYTEIFMENGYSSMDAVAQVTLE
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). {ECO:0000250, ECO:0000269|PubMed:20824214, ECO:0000269|PubMed:7748564, ECO:0000269|PubMed:9698392}.
uniprot
proteins
mass_dalton
111007
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation is stimulated by the ligand EFNA5. Dephosphorylation upon stimulation by glucose, inhibits EPHA5 forward signaling and results in insulin secretion (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Ephrin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
20824214
uniprot
proteins
pubmed
7504232
uniprot
proteins
pubmed
7748564
uniprot
proteins
pubmed
7898646
uniprot
proteins
pubmed
9698392
uniprot
proteins
sequence_length
1005
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20824214, ECO:0000269|PubMed:7748564}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000269|PubMed:20824214, ECO:0000269|PubMed:7748564}. Cell projection, dendrite {ECO:0000250|UniProtKB:P54756}.
uniprot
proteins
transmembrane_region
TRANSMEM 576..596; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins