Lrrtm2
entrez
685472
canonical
uniprot
D4A7P2
canonical
ensembl
ENSRNOG00000047085
resolver
ensembl
ENSRNOG00055023116
resolver
ensembl
ENSRNOG00060026552
resolver
ensembl
ENSRNOG00065012607
resolver
ensp
ENSRNOP00000067172
resolver
ensp
ENSRNOP00055032244
resolver
ensp
ENSRNOP00060038179
resolver
ensp
ENSRNOP00065015760
resolver
enst
ENSRNOT00000075420
resolver
enst
ENSRNOT00055039707
resolver
enst
ENSRNOT00060045986
resolver
enst
ENSRNOT00065020507
resolver
genesymbol
Lrrtm2
resolver
uniprot_entry
LRRT2_RAT
resolver
amino_acid_sequence
MGLHFKWPLGAPMLAAIYAMSVVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITALERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWSTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILSSLRSLTTVGLSGNLWECSPRVCALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLCWNLSTTVTAMATTYRDPTTEYTKISSSSYHVGDKEIPTTAGIAVTTEEHFPEPDNAIFTQRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMIQNHRQLRSQTRLHMSNMSDQGPYSEYEPTHEGPFIIINGYGQCKCQQLPYKECEV
uniprot
proteins
function
FUNCTION: Involved in the development and maintenance of excitatory synapses in the nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B. {ECO:0000269|PubMed:19285470, ECO:0000269|PubMed:20064388, ECO:0000269|PubMed:30100184}.
uniprot
proteins
mass_dalton
58804
uniprot
proteins
mutagenesis
MUTAGEN 157..158; /note="RK->AA: Reduced heparan sulfate binding and reduced induction of presynaptic differentiation; when associated with A-181, A-206 and A-208."; /evidence="ECO:0000269|PubMed:30100184"; MUTAGEN 181; /note="R->A: Reduced heparan sulfate binding and reduced induction of presynaptic differentiation; when associated with 157-A-A-158, A-206 and A-208."; /evidence="ECO:0000269|PubMed:30100184"; MUTAGEN 206; /note="K->A: Reduced heparan sulfate binding and reduced induction of presynaptic differentiation; when associated with 157-A-A-158, A-181 and A-208."; /evidence="ECO:0000269|PubMed:30100184"; MUTAGEN 208; /note="R->A: Reduced heparan sulfate binding and reduced induction of presynaptic differentiation; when associated with 157-A-A-158; A-181 and A-206."; /evidence="ECO:0000269|PubMed:30100184"; MUTAGEN 512..515; /note="Missing: Loss of DLG4-binding."; /evidence="ECO:0000269|PubMed:19285470
uniprot
proteins
protein_family
LRRTM family
uniprot
proteins
pubmed
19285470
uniprot
proteins
pubmed
20064388
uniprot
proteins
pubmed
30100184
uniprot
proteins
sequence_length
515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Postsynaptic cell membrane; Single-pass type I membrane protein. Note=Localized to excitatory synapses.
uniprot
proteins
transmembrane_region
TRANSMEM 422..442; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins