Q63560
uniprot
Q63560
canonical
amino_acid_sequence
MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPAPPQPGLAPPSRAVAIETQPAQGESDAVARATGPAPGPSGDRETAAAPGRSGLGLGAASGSTSGSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQIPATSQPSPPVLGMPKRRPQSQERGPIQLSADARDPEGAGGAGVPAAGKASGADQRDTRRKAGPAWMVTRTEGHEEKPLPPAQSQTQEGGPAAGKASGADQRDTRRKAGPAWMVTRTEGHEEKPLPPAQSQTQEGGPAAGKASGADQRDTRRKAGPAWMVTRTEGHEETPLPPAQSQTQEGGPAAGKASGADQRDTRRKAGPAWMVTRTEGHEETPLPPAQSQTQEGGPAAGKASGADERDTRRKAGPAWMVRRSEGHEQTTAAHAQGTGPEGGKGRAVADALNRQIREEVTSTVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVVDRRRIRSLYSEPFKESPKVEKPSVQSSKPKKTSTSQKPLRKAKDKQVASGQAAKKKTTESPSATKPDDKEQSKEMNNKLAEAKESRVKPTSDKNQGPVAKEPHKDQGPVAPGLPKGQGPAVQEPLKDQGPMVPGLPKDQAPVVPGSLKGQSPTAPGPPKDQGAVLLGPMKDLGPVAPASVKDQDHMASELLKNKDSVPLAPAKAQSPLLPEPLKNQSPVVPARAKDQSFPAPAPTPLKDPGPVIPEPEKDGAPMVPERRKDQNASIMASLKNEAPVASESVKNQGLGGPEPAKDTGTDLKGHGSVFVAPVKSQGPVVPEPTKGQDPIIPALAKDQGPILPEPPKNQGPPVVLGPIKNQDPVIPVPLKGQDPVVPAPTKDPGPTAPDPLKSQGPRGPQLPTVSPSPPVMIPTVPHAEYIEGSP
uniprot
proteins
function
FUNCTION: Involved in microtubule stabilization in many cell types, including neuronal cells (PubMed:11413126, PubMed:28521134, PubMed:3456161, PubMed:8700896, PubMed:9660871). Specifically has microtubule cold stabilizing activity (PubMed:3456161). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (By similarity). Regulates KIF5A-mediated axonal cargo transport (PubMed:28521134). Regulates axonal growth during neuron polarization (PubMed:28521134). {ECO:0000250|UniProtKB:Q96JE9, ECO:0000269|PubMed:11413126, ECO:0000269|PubMed:28521134, ECO:0000269|PubMed:3456161, ECO:0000269|PubMed:8700896, ECO:0000269|PubMed:9660871}.
uniprot
proteins
mass_dalton
100485
uniprot
proteins
mutagenesis
MUTAGEN 5; /note="C->G: Loss of palmitoylation. Loss of Golgi and secretory vesicle localization; when associated with G-10 and G-11. Loss of axonal polarization; when associated with G-10 and G-11. Increased dendrite localization without affecting association with microtubules; when associated with G-10 and G-11."; /evidence="ECO:0000269|PubMed:28521134"; MUTAGEN 10..11; /note="CC->GG: Loss of Golgi and secretory vesicle localization; when associated with G-5. Loss of axonal polarization; when associated with G-5. Increased dendrite localization without affecting association with microtubules; when associated with G-5."; /evidence="ECO:0000269|PubMed:28521134
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Probably depalmitoylated by ABHD17A, ABHD17B and ABHD17C. During neuronal polarization, palmitoylation and depalmitoylation cycles regulate MAP6 shuttling between secretory vesicles and microtubules, and its polarized distribution in the axon. {ECO:0000269|PubMed:28521134}.
uniprot
proteins
protein_family
STOP family
uniprot
proteins
pubmed
11413126
uniprot
proteins
pubmed
14724383
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24357581
uniprot
proteins
pubmed
28521134
uniprot
proteins
pubmed
3456161
uniprot
proteins
pubmed
8700896
uniprot
proteins
pubmed
9660871
uniprot
proteins
sequence_length
952
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14724383, ECO:0000269|PubMed:28521134, ECO:0000269|PubMed:3456161, ECO:0000269|PubMed:8700896, ECO:0000269|PubMed:9660871}. Golgi apparatus {ECO:0000269|PubMed:28521134}. Cell projection, axon {ECO:0000269|PubMed:28521134, ECO:0000269|PubMed:9660871}. Cell projection, dendrite {ECO:0000269|PubMed:28521134}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:28521134}; Lipid-anchor {ECO:0000269|PubMed:28521134}; Cytoplasmic side {ECO:0000269|PubMed:28521134}. Note=Isoform 1 and isoform 2 associate with axonal microtubules in neuronal cells (PubMed:8700896, PubMed:9660871). Localizes predominantly in the proximal part of the axon (PubMed:28521134). Preferentially concentrated on a portion of the microtubule polymer in which tubulin is modified by detyrosination and acetylation and is also resistant to depolymerization induced by both nocodazole and cold (PubMed:14724383, PubMed:28521134, PubMed:9660871). In unpolarized neurons, localizes to the Golgi and to secretory vesicles accumulating transiently at the tips of a subset of neurites (PubMed:28521134). Following neuronal polarization and during axon outgrowth, accumulates in the axonal growth cone and subsequently localizes throughout the axon (PubMed:28521134). Partially localizes to dendrites in mature neurons (PubMed:28521134). {ECO:0000269|PubMed:14724383, ECO:0000269|PubMed:28521134, ECO:0000269|PubMed:8700896, ECO:0000269|PubMed:9660871}.
uniprot
proteins