Marchf8
entrez
71779
canonical
uniprot
Q9DBD2
canonical
ensembl
ENSMUSG00000025702
resolver
ensp
ENSMUSP00000078024
resolver
ensp
ENSMUSP00000098594
resolver
ensp
ENSMUSP00000115510
resolver
ensp
ENSMUSP00000144936
resolver
ensp
ENSMUSP00000145137
resolver
ensp
ENSMUSP00000274221
resolver
ensp
ENSMUSP00000274230
resolver
ensp
ENSMUSP00000274254
resolver
ensp
ENSMUSP00000274257
resolver
enst
ENSMUST00000079012
resolver
enst
ENSMUST00000101032
resolver
enst
ENSMUST00000123405
resolver
enst
ENSMUST00000203193
resolver
genesymbol
Marchf8
resolver
genesymbol_syn
March8
resolver
genesymbol_syn
Mir
resolver
uniprot
A0A0N4SV35
resolver
uniprot
A0A0N4SVK0
resolver
uniprot_entry
A0A0N4SV35_MOUSE
resolver
uniprot_entry
A0A0N4SVK0_MOUSE
resolver
uniprot_entry
MARH8_MOUSE
resolver
amino_acid_sequence
MSMPLHQISAIPSQDAISARVYRSKTKDKEQNEKTLGHSMSHPSNISKAGSSPPSTTAPVSAFSRTSVTPSNQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTASERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQVTGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYLQLWKRLKAYNRVIYVQNCPETSKKNIFEKSALTEPTLENKEGHGMCHSTTNSSCTEPEDTGAEIINV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity (PubMed:16785530, PubMed:35503863). Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins. Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation. Mediates the regulation of constitutive ubiquitination and trafficking of the viral restriction factor BST2 within the endocytic pathway. Plays a role in maintenance of immune tolerance to self by promoting the turnover and proteasomal degradation of PD-L1/CD274 via ubiquitination. Catalyzes the 'Lys-63'-linked polyubiquitylation of cGAS thereby inhibiting its DNA binding ability and impairing its antiviral innate immunity (PubMed:35503863). Negatively regulates IL7-mediated T-cell homeostasis by mediating 'Lys-27'-linked polyubiquitination of IL7R, leading to its lysosomal degradation (By similarity). {ECO:0000250|UniProtKB:Q5T0T0, ECO:0000269|PubMed:16785530, ECO:0000269|PubMed:35503863}.
uniprot
proteins
mass_dalton
32243
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q5T0T0}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16785530
uniprot
proteins
pubmed
35503863
uniprot
proteins
sequence_length
286
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q5T0T0}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5T0T0}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q5T0T0}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q5T0T0}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q5T0T0}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 153..173; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins