Cd28
entrez
25660
canonical
uniprot
P31042
canonical
genesymbol
Cd28
resolver
uniprot_entry
CD28_RAT
resolver
amino_acid_sequence
MTLRLLFLALSFFSVQVTENKILVKQSPLLVVDNNEVSLSCRYSYNLLAKEFRASLYKGVNSDVEVCVGNGNFTYQPQFRPNVGFNCDGNFDNETVTFRLWNLDVNHTDIYFCKIEVMYPPPYLDNEKSNGTIIHIKEKHLCHAQTSPKLFWPLVVVAGVLLCYGLLVTVTLCIIWTNSRRNRLLQSDYMNMTPRRLGPTRKHYQPYAPARDFAAYRP
uniprot
proteins
function
FUNCTION: Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis. Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells. {ECO:0000250|UniProtKB:P10747}.
uniprot
proteins
mass_dalton
25170
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by LCK. Dephosphorylated by PTPN11. {ECO:0000250|UniProtKB:P10747}.
uniprot
proteins
pubmed
1309509
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P10747}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P10747}.
uniprot
proteins
transmembrane_region
TRANSMEM 151..177; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins