CCL7
entrez
6354
canonical
uniprot
P80098
canonical
ensembl
ENSG00000108688
resolver
ensp
ENSP00000367832
resolver
enst
ENST00000378569
resolver
genesymbol
CCL7
resolver
genesymbol_syn
MCP3
resolver
genesymbol_syn
SCYA6
resolver
genesymbol_syn
SCYA7
resolver
hgnc
HGNC:10634
resolver
uniprot
Q569J6
resolver
uniprot_entry
CCL7_HUMAN
resolver
uniprot_sec
Q569J6
resolver
amino_acid_sequence
MKASAALLCLLLTAAAFSPQGLAQPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEICADPTQKWVQDFMKHLDKKTQTPKL
uniprot
proteins
function
FUNCTION: Chemotactic factor that plays an important role in immune regulation. Attracts monocytes, eosinophils, basophils, and T-cells to sites of inflammation or infection. Upon binding to various chemokine receptors including CCR1, CCR2, CCR3, and CCR5, facilitates immune cell migration by guiding them to infected tissues (PubMed:9364936, PubMed:10477718). Interacts with CCR2 to facilitate the release of monocytes from the bone marrow into the bloodstream, maintaining monocyte homeostasis. In turn, monocytes recruited to inflamed or injured tissues can differentiate into macrophages or dendritic cells, which are essential for immune defense and tissue repair. Through CCR1, contributes to macrophage polarization via NF-kappa-B activation which leads to the release of inflammatory factors (PubMed:38417634). In the trigeminal ganglion neurons, activates ERK via CCR2 and CCR3 to enhance neuronal excitability, which contributes to the maintenance of trigeminal neuropathic pain. Additionally, modulates the early immune response in the skin, preventing pathogen dissemination while maintaining cutaneous immune control. {ECO:0000250|UniProtKB:Q03366, ECO:0000269|PubMed:10477718, ECO:0000269|PubMed:38417634, ECO:0000269|PubMed:9364936}.
uniprot
proteins
mass_dalton
11200
uniprot
proteins
mutagenesis
MUTAGEN 41; /note="K->A: Decreases binding to Link domain of TNFAIP6; when associated with A-42 and A-45."; /evidence="ECO:0000269|PubMed:27044744"; MUTAGEN 42; /note="K->A: Decreases binding to Link domain of TNFAIP6; when associated with A-41 and A-45."; /evidence="ECO:0000269|PubMed:27044744"; MUTAGEN 45; /note="K->A: Decreases binding to Link domain of TNFAIP6; when associated with A-41 and A-42."; /evidence="ECO:0000269|PubMed:27044744
uniprot
proteins
post_translational_modification
PTM: O-glycosylated.
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
10477718
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1613466
uniprot
proteins
pubmed
27044744
uniprot
proteins
pubmed
38417634
uniprot
proteins
pubmed
7916328
uniprot
proteins
pubmed
8318676
uniprot
proteins
pubmed
8461011
uniprot
proteins
pubmed
8898111
uniprot
proteins
pubmed
9109648
uniprot
proteins
pubmed
9364936
uniprot
proteins
sequence_length
99
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins