Tas1r3
entrez
83771
canonical
uniprot
Q925D8
canonical
ensembl
ENSMUSG00000029072
resolver
ensp
ENSMUSP00000030949
resolver
enst
ENSMUST00000030949
resolver
genesymbol
Tas1r3
resolver
genesymbol_syn
Sac
resolver
genesymbol_syn
T1r3
resolver
genesymbol_syn
Tr3
resolver
uniprot
A2ADA0
resolver
uniprot
Q91VA4
resolver
uniprot
Q923K0
resolver
uniprot
Q925A4
resolver
uniprot
Q925D9
resolver
uniprot_entry
TS1R3_MOUSE
resolver
uniprot_sec
A2ADA0
resolver
uniprot_sec
Q91VA4
resolver
uniprot_sec
Q923K0
resolver
uniprot_sec
Q925A4
resolver
uniprot_sec
Q925D9
resolver
amino_acid_sequence
MPALAIMGLSLAAFLELGMGASLCLSQQFKAQGDYILGGLFPLGSTEEATLNQRTQPNSIPCNRFSPLGLFLAMAMKMAVEEINNGSALLPGLRLGYDLFDTCSEPVVTMKSSLMFLAKVGSQSIAAYCNYTQYQPRVLAVIGPHSSELALITGKFFSFFLMPQVSYSASMDRLSDRETFPSFFRTVPSDRVQLQAVVTLLQNFSWNWVAALGSDDDYGREGLSIFSSLANARGICIAHEGLVPQHDTSGQQLGKVLDVLRQVNQSKVQVVVLFASARAVYSLFSYSIHHGLSPKVWVASESWLTSDLVMTLPNIARVGTVLGFLQRGALLPEFSHYVETHLALAADPAFCASLNAELDLEEHVMGQRCPRCDDIMLQNLSSGLLQNLSAGQLHHQIFATYAAVYSVAQALHNTLQCNVSHCHVSEHVLPWQLLENMYNMSFHARDLTLQFDAEGNVDMEYDLKMWVWQSPTPVLHTVGTFNGTLQLQQSKMYWPGNQVPVSQCSRQCKDGQVRRVKGFHSCCYDCVDCKAGSYRKHPDDFTCTPCNQDQWSPEKSTACLPRRPKFLAWGEPVVLSLLLLLCLVLGLALAALGLSVHHWDSPLVQASGGSQFCFGLICLGLFCLSVLLFPGRPSSASCLAQQPMAHLPLTGCLSTLFLQAAETFVESELPLSWANWLCSYLRGLWAWLVVLLATFVEAALCAWYLIAFPPEVVTDWSVLPTEVLEHCHVRSWVSLGLVHITNAMLAFLCFLGTFLVQSQPGRYNRARGLTFAMLAYFITWVSFVPLLANVQVAYQPAVQMGAILVCALGILVTFHLPKCYVLLWLPKLNTQEFFLGRNAKKAADENSGGGEAAQGHNE
uniprot
proteins
function
FUNCTION: Key component of the sweet and umami taste receptors (By similarity). TAS1R1 and TAS1R3 form the umami receptor and respond to the umami taste stimulus (the taste of monosodium glutamate) (PubMed:11894099). TAS1R2 and TAS1R3 form the sweet taste receptor and recognize diverse natural and synthetic sweeteners (By similarity). The sweet taste receptor has lower affinity for natural sugars than for synthetic sweeteners (By similarity). Essential for the recognition and response to the disaccharide trehalose (PubMed:12892531). Functions as a G protein-coupled receptor and primarily signals through the gustducin heterotrimer (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity). {ECO:0000250|UniProtKB:Q49KI5, ECO:0000250|UniProtKB:Q7RTX0, ECO:0000269|PubMed:11894099, ECO:0000269|PubMed:12892531}.
uniprot
proteins
mass_dalton
94561
uniprot
proteins
post_translational_modification
PTM: The Thr-60 variant is predicted to introduce a novel N-linked glycosylation site at Asn-58. The addition of even a short carbohydrate group at Asn-58 is predicted to disrupt one of the contact surfaces required for stability of a dimer. Therefore a Thr-60 variant N-glycosylated at Asn-58 is predicted to be precluded from forming homodimers or heterodimers. {ECO:0000269|PubMed:11326277}.
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
protein_family
TAS1R subfamily
uniprot
proteins
pubmed
11319557
uniprot
proteins
pubmed
11322794
uniprot
proteins
pubmed
11326277
uniprot
proteins
pubmed
11331418
uniprot
proteins
pubmed
11509186
uniprot
proteins
pubmed
11555487
uniprot
proteins
pubmed
11773963
uniprot
proteins
pubmed
11894099
uniprot
proteins
pubmed
12869700
uniprot
proteins
pubmed
12892531
uniprot
proteins
pubmed
14636554
uniprot
proteins
pubmed
14749438
uniprot
proteins
pubmed
14999080
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
40754567
uniprot
proteins
sequence_length
858
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7RTX0}; Multi-pass membrane protein {ECO:0000269|PubMed:40754567}.
uniprot
proteins
transmembrane_region
TRANSMEM 576..596; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:40754567, ECO:0007744|PDB:9OPZ, ECO:0007744|PDB:9OQ1, ECO:0007744|PDB:9OQ2, ECO:0007744|PDB:9OQ3"; TRANSMEM 609..629; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:40754567, ECO:0007744|PDB:9OPZ, ECO:0007744|PDB:9OQ1, ECO:0007744|PDB:9OQ2, ECO:0007744|PDB:9OQ3"; TRANSMEM 645..665; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:40754567, ECO:0007744|PDB:9OPZ, ECO:0007744|PDB:9OQ1, ECO:0007744|PDB:9OQ2, ECO:0007744|PDB:9OQ3"; TRANSMEM 688..708; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:40754567, ECO:0007744|PDB:9OPZ, ECO:0007744|PDB:9OQ1, ECO:0007744|PDB:9OQ2, ECO:0007744|PDB:9OQ3"; TRANSMEM 735..755; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:40754567, ECO:0007744|PDB:9OPZ, ECO:0007744|PDB:9OQ1, ECO:0007744|PDB:9OQ2, ECO:0007744|PDB:9OQ3"; TRANSMEM 768..788; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:40754567, ECO:0007744|PDB:9OPZ, ECO:0007744|PDB:9OQ1, ECO:0007744|PDB:9OQ2, ECO:0007744|PDB:9OQ3"; TRANSMEM 795..818; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:40754567, ECO:0007744|PDB:9OPZ, ECO:0007744|PDB:9OQ1, ECO:0007744|PDB:9OQ2, ECO:0007744|PDB:9OQ3
uniprot
proteins