Rab3d
entrez
140665
canonical
uniprot
Q63942
canonical
ensembl
ENSRNOG00000011582
resolver
ensp
ENSRNOP00000015609
resolver
genesymbol
Rab3d
resolver
genesymbol_syn
Rab16
resolver
uniprot
P35291
resolver
uniprot_entry
RAB3D_RAT
resolver
uniprot_sec
P35291
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation. {ECO:0000250|UniProtKB:P20336}.
uniprot
proteins
amino_acid_sequence
MASASEPPASPRDAADQNFDYMFKLLLIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTVYRHDKRIKLQIWDTAGQERYRTITTAYYRGAMGFLLMYDIANQESFTAVQDWATQIKTYSWDNAQVILVGNKCDLEDERVVSAEDGQRLAGDLGFEFFEASAKENINVKQVFERLVDIICDKMNESLEPSSSPGSNGKGPALGDTPPPQPSSCGC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB3D may be involved in the insulin-induced exocytosis of GLUT4-containing vesicles in adipocytes (By similarity). {ECO:0000250|UniProtKB:P20336, ECO:0000250|UniProtKB:P35276}.
uniprot
proteins
mass_dalton
24290
uniprot
proteins
post_translational_modification
PTM: In fetal glands the majority of the proteins are methylated, whereas in neonatal and adult glands, only 50% are methylated. {ECO:0000269|PubMed:9716267}.; PTM: Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM. {ECO:0000250|UniProtKB:O95716}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
1313420
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7508866
uniprot
proteins
pubmed
7532276
uniprot
proteins
pubmed
9300704
uniprot
proteins
pubmed
9716267
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
uniprot
proteins