Sephs1
entrez
109079
canonical
uniprot
Q8BH69
canonical
ensembl
ENSMUSG00000026662
resolver
ensp
ENSMUSP00000027973
resolver
ensp
ENSMUSP00000110671
resolver
ensp
ENSMUSP00000211198
resolver
ensp
ENSMUSP00000211204
resolver
enst
ENSMUST00000027973
resolver
enst
ENSMUST00000115019
resolver
genesymbol
Sephs1
resolver
genesymbol_syn
Sps1
resolver
uniprot
Q6NZN9
resolver
uniprot
Q6P1B6
resolver
uniprot_entry
Q6NZN9_MOUSE
resolver
uniprot_entry
Q6P1B6_MOUSE
resolver
uniprot_entry
SPS1_MOUSE
resolver
amino_acid_sequence
MSTRESFNPETYELDKSFRLTRFTELKGTGCKVPQDVLQKLLESLQENHFQEDEQFLGAVMPRLGIGMDTCVIPLRHGGLSLVQTTDYIYPIVDDPYMMGRIACANVLSDLYAMGVTECDNMLMLLGVSNKMTDRERDKVIPLIIQGFKDAAEEAGTSVTGGQTVLNPWIVLGGVATTVCQPNEFIMPDNAVPGDVLVLTKPLGTQVAVAVHQWLDIPEKWNKIKLVVTQEDVELAYQEAMMNMARLNRTAAGLMHTFNAHAATDITGFGILGHAQNLAKQQRNEVSFVIHNLPVLAKMAAVSKACGNMFGLMHGTCPETSGGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNRTARIIDKPRIIEVAPQVATQNVNPTPGATS
uniprot
proteins
ec_number
2.7.9.3
uniprot
proteins
function
FUNCTION: Core component of the zincore complex, a heterotetramer that acts as a molecular 'grip' to stabilize transcription factors at DNA-binding sites across the genome, thereby controlling gene expression (By similarity). The zincore complex binds specifically to zinc finger transcription factors, such as ZFP91, ZNF652, ZNF526 and PRDM15, and stabilizes them onto their cognate DNA motif (By similarity). Within the complex, SEPHS1, recognizes and binds the backbone of zinc fingers of transcription factors in a sequence-independent manner via its arginine clamp, enhancing their DNA-binding stability (By similarity). Plays an essential role in redox homeostasis (PubMed:27208177, PubMed:34769076, PubMed:34769078, PubMed:35140209). May also be involved in selenocysteine biosynthesis by catalyzing formation of selenophosphate from selenide and ATP (By similarity). Its role in selenocysteine biosynthesis is however unclear and several studies suggest that it does not act as a selenophosphate synthase in vivo or plays an non-essential role (PubMed:17194211, PubMed:17346238). Required for cardiac differentiation (PubMed:34974300). {ECO:0000250|UniProtKB:P49903, ECO:0000269|PubMed:17194211, ECO:0000269|PubMed:17346238, ECO:0000269|PubMed:27208177, ECO:0000269|PubMed:34769076, ECO:0000269|PubMed:34769078, ECO:0000269|PubMed:34974300, ECO:0000269|PubMed:35140209}.
uniprot
proteins
mass_dalton
42907
uniprot
proteins
protein_family
Class II subfamily
uniprot
proteins
protein_family
Selenophosphate synthase 1 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17194211
uniprot
proteins
pubmed
17346238
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27208177
uniprot
proteins
pubmed
34769076
uniprot
proteins
pubmed
34769078
uniprot
proteins
pubmed
34974300
uniprot
proteins
pubmed
35140209
uniprot
proteins
sequence_length
392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P49903}. Chromosome {ECO:0000250|UniProtKB:P49903}. Cytoplasm {ECO:0000250|UniProtKB:P49903}. Note=The zincore complex binds to a highly conserved promoter motif (5'-CTTTAAR-3'). {ECO:0000250|UniProtKB:P49903}.
uniprot
proteins