Cd74
entrez
16149
canonical
uniprot
P04441
canonical
ensembl
ENSMUSG00000024610
resolver
ensp
ENSMUSP00000057836
resolver
ensp
ENSMUSP00000095171
resolver
genesymbol
Cd74
resolver
genesymbol_syn
Ii
resolver
uniprot
O19452
resolver
uniprot
Q3U4Q8
resolver
uniprot
Q545Y5
resolver
uniprot_entry
HG2A_MOUSE
resolver
uniprot_entry
Q3U4Q8_MOUSE
resolver
uniprot_entry
Q545Y5_MOUSE
resolver
uniprot_sec
O19452
resolver
amino_acid_sequence
MDDQRDLISNHEQLPILGNRPREPERCSRGALYTGVSVLVALLLAGQATTAYFLYQQQGRLDKLTITSQNLQLESLRMKLPKSAKPVSQMRMATPLLMRPMSMDNMLLGPVKNVTKYGNMTQDHVMHLLTRSGPLEYPQLKGTFPENLKHLKNSMDGVNWKIFESWMKQWLLFEMSKNSLEEKKPTEAPPKVLTKCQEEVSHIPAVYPGAFRPKCDENGNYLPLQCHGSTGYCWCVFPNGTEVPHTKSRGRHNCSEPLDMEDLSSGLGVTRQELGQVTL
uniprot
proteins
function
FUNCTION: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. {ECO:0000269|PubMed:8343954, ECO:0000269|PubMed:8977190}.; FUNCTION: [Isoform Long]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). {ECO:0000269|PubMed:11483509, ECO:0000269|PubMed:12417635}.; FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. {ECO:0000250|UniProtKB:P04233}.
uniprot
proteins
mass_dalton
31557
uniprot
proteins
mutagenesis
MUTAGEN 265; /note="S->A: No addition of glycosaminoglycan; no effect on the synthesis of the protein."; /evidence="ECO:0000269|PubMed:3422739
uniprot
proteins
pubmed
11483509
uniprot
proteins
pubmed
12417635
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
2111346
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2492095
uniprot
proteins
pubmed
3038530
uniprot
proteins
pubmed
32855215
uniprot
proteins
pubmed
3422739
uniprot
proteins
pubmed
6327293
uniprot
proteins
pubmed
8343954
uniprot
proteins
pubmed
8977190
uniprot
proteins
sequence_length
279
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Long]: Late endosome {ECO:0000269|PubMed:11483509}. Lysosome {ECO:0000269|PubMed:11483509}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P04233}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P04233}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04233}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P04233}. Endosome {ECO:0000250|UniProtKB:P04233}. Lysosome {ECO:0000250|UniProtKB:P04233}. Secreted {ECO:0000250|UniProtKB:P04233}. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane. {ECO:0000250|UniProtKB:P04233}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..55; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins