Sv2c
entrez
29643
canonical
uniprot
Q9Z2I6
canonical
ensembl
ENSRNOG00000018094
resolver
ensembl
ENSRNOG00055027955
resolver
ensembl
ENSRNOG00060029133
resolver
ensembl
ENSRNOG00065024595
resolver
ensp
ENSRNOP00000024459
resolver
ensp
ENSRNOP00055039787
resolver
ensp
ENSRNOP00060042078
resolver
ensp
ENSRNOP00065034527
resolver
enst
ENSRNOT00055048390
resolver
enst
ENSRNOT00060050561
resolver
enst
ENSRNOT00065042223
resolver
genesymbol
Sv2c
resolver
uniprot_entry
SV2C_RAT
resolver
amino_acid_sequence
MEDSYKDRTSLMKGAKDIAKEVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEDDDDDYYPPGETYSGEANDDEGSSEATEGHDEEDEIYEGEYQGIPSTNQGKDSIVSVGQPKGDEYKDRRELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLLCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRENTIKLTIVWFTLSFGYYGLSVWFPDVIKHLQSDEYALLTRNVQKDKYANFSINFTMENQVHTGMEYDNGRFLGVKFKSVTFKDSVFKSCTFDDVTSVNTYFKNCTFIDTLFENTDFEPYKFIDSEFQNCSFLHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDTRTQVLM
uniprot
proteins
function
FUNCTION: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. {ECO:0000269|PubMed:15866046, ECO:0000269|PubMed:16306227}.; FUNCTION: (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin binds Sv2c via extracellular loop 4 (PubMed:16543415, PubMed:27294781). Restores uptake of BoNT/A in rat cells that are deleted for SV2 receptor (PubMed:16543415, PubMed:18815274). {ECO:0000269|PubMed:16543415, ECO:0000269|PubMed:19650874, ECO:0000269|PubMed:27294781}.; FUNCTION: (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); BoNT/D does not bind to extracellular loop 4 as do BoNT/A and BoNT/E (PubMed:21483489). Another group does not find a convincing interaction with SV2 (PubMed:21632541). {ECO:0000269|PubMed:21483489, ECO:0000269|PubMed:21632541}.; FUNCTION: (Microbial infection) Receptor for C.botulinum neurotoxin type F (BoNT/F); binding requires glycosylation of Asn-573 (PubMed:19476346, PubMed:19650874). {ECO:0000269|PubMed:19650874, ECO:0000305|PubMed:19476346}.
uniprot
proteins
mass_dalton
82249
uniprot
proteins
mutagenesis
MUTAGEN 559; /note="N->A: Loss of one glycosylation site. No effect on C.botulinum neurotoxin type A (BoNT/A, botA) binding, but reduces the uptake of BoNT/A."; /evidence="ECO:0000269|PubMed:27294781
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10625067, ECO:0000269|PubMed:27294781, ECO:0000269|PubMed:9801366}.
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
pubmed
10625067
uniprot
proteins
pubmed
15866046
uniprot
proteins
pubmed
16306227
uniprot
proteins
pubmed
16543415
uniprot
proteins
pubmed
18815274
uniprot
proteins
pubmed
19476346
uniprot
proteins
pubmed
19650874
uniprot
proteins
pubmed
21483489
uniprot
proteins
pubmed
21632541
uniprot
proteins
pubmed
27294781
uniprot
proteins
pubmed
9801366
uniprot
proteins
sequence_length
727
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:10625067, ECO:0000269|PubMed:16306227}; Multi-pass membrane protein {ECO:0000269|PubMed:10625067, ECO:0000269|PubMed:16306227}. Note=Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas.
uniprot
proteins
transmembrane_region
TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 227..247; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 249..269; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 281..301; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 321..341; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 438..458; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 579..599; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 610..630; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 637..657; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 671..693; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 698..716; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins