Q9QYC5
uniprot
Q9QYC5
canonical
amino_acid_sequence
MRWLWPLAVSLAVVLAVGPSEVSGAATLSLGGHRAKVQEQQSRPRRGTKDEGPKEVQHYVPEEWAEYPKPIHPAGLQPTKPLVATSPNPDKDGATSESGQELRTNLTGTPSQRLQIQNPLYPVTESSYSAYAVMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMMLAVPELLLWQLAQEPTPTMGTVDSCIMKPSADLPESLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKPECRAGRHEQCESQLNSTVVGLTVVYAFCTLPENICNIVVAYLSTELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASDSSATVSADSKLKAEVSSSIYFHKPRESPPLLPLGTPC
uniprot
proteins
function
FUNCTION: G protein-coupled receptor (By similarity). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity). {ECO:0000250|UniProtKB:O60883, ECO:0000250|UniProtKB:Q99JG2}.
uniprot
proteins
mass_dalton
52860
uniprot
proteins
post_translational_modification
PTM: Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity. {ECO:0000269|PubMed:27072655}.; PTM: Ubiquitinated. {ECO:0000250|UniProtKB:O60883}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10350639
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
27072655
uniprot
proteins
sequence_length
481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O60883}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q99JG2}; Multi-pass membrane protein {ECO:0000255}. Note=Associates with the basal membrane of Bergmann glia cell primary cilia. {ECO:0000250|UniProtKB:Q99JG2}.
uniprot
proteins
transmembrane_region
TRANSMEM 135..155; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 206..226; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 252..272; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 361..381; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 399..419; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins