Ipmk
entrez
69718
canonical
uniprot
Q7TT16
canonical
ensembl
ENSMUSG00000060733
resolver
ensp
ENSMUSP00000078240
resolver
ensp
ENSMUSP00000112568
resolver
enst
ENSMUST00000121446
resolver
genesymbol
Ipmk
resolver
genesymbol_syn
Impk
resolver
genesymbol_syn
Ipk2
resolver
uniprot
D3YWA2
resolver
uniprot
Q8BZ11
resolver
uniprot
Q8BZA8
resolver
uniprot
Q9CWM9
resolver
uniprot_entry
D3YWA2_MOUSE
resolver
uniprot_entry
IPMK_MOUSE
resolver
uniprot_sec
Q8BZ11
resolver
uniprot_sec
Q8BZA8
resolver
uniprot_sec
Q9CWM9
resolver
amino_acid_sequence
MAAEPPALRLRPPGSTGDSPPVPRLLGGCVPLSHQVAGHMYGKDKVGILQHPDGTVLKQLQPPPRGPRELEFYTMVYAADCADAVLLELRKHLPKYYGVWSPPTAPNDVYLKLEDVTHKFNKPCIMDVKIGRKSYDPFASSEKIQQQVSKYPLMEEIGFLVLGMRVYHLHSDSYETQNQHYGRGLTKETLKEGVSKFFHNGFCLRKDAIAASIQKVEKILQWFENQKQLNFYASSLLFVYEGSSQPATTKANDRTLAGRFLSKGPLTDADGLECNNNFHLFGAPPNGMSVGKSLSKAYSRHRKLYAKKHQSQTSLKVETLEQDNGWRSMSQEHLNGNVLAQLEKVFYHLPAGRPEIPEAEVRMIDFAHVFPSNTVDEGYVYGLKHLIAVLRSILDS
uniprot
proteins
ec_number
2.7.1.140
uniprot
proteins
ec_number
2.7.1.151
uniprot
proteins
ec_number
2.7.1.153
uniprot
proteins
function
FUNCTION: Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:15939867). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (By similarity). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (By similarity). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (PubMed:15939867). {ECO:0000250|UniProtKB:Q8NFU5, ECO:0000250|UniProtKB:Q99NI4, ECO:0000269|PubMed:15939867}.
uniprot
proteins
mass_dalton
44453
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylinositol metabolism. {ECO:0000269|PubMed:15939867}.
uniprot
proteins
protein_family
Inositol phosphokinase (IPK) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15939867
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8NFU5}.
uniprot
proteins