INTS6
entrez
26512
canonical
uniprot
Q9UL03
canonical
ensembl
ENSG00000102786
resolver
ensp
ENSP00000310260
resolver
ensp
ENSP00000381187
resolver
ensp
ENSP00000411245
resolver
ensp
ENSP00000419871
resolver
ensp
ENSP00000419984
resolver
enst
ENST00000497989
resolver
genesymbol
INTS6
resolver
genesymbol_syn
DBI1
resolver
genesymbol_syn
DDX26
resolver
genesymbol_syn
DDX26A
resolver
hgnc
HGNC:14879
resolver
uniprot
A1MXB9
resolver
uniprot
B3KU90
resolver
uniprot
F6W6Q7
resolver
uniprot
Q0P664
resolver
uniprot
Q6PJP4
resolver
uniprot
Q9UFK0
resolver
uniprot
Q9Y5M9
resolver
uniprot_entry
B3KU90_HUMAN
resolver
uniprot_entry
F6W6Q7_HUMAN
resolver
uniprot_entry
INT6_HUMAN
resolver
uniprot_sec
A1MXB9
resolver
uniprot_sec
Q0P664
resolver
uniprot_sec
Q6PJP4
resolver
uniprot_sec
Q9UFK0
resolver
uniprot_sec
Q9Y5M9
resolver
amino_acid_sequence
MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGPDPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPNMQGIPKRRRCMSPLLRGRQQNPVVNNHIGGKGPPAPTTQAQPDLIKPLPLHKISETTNDSIIHDVVENHVADQLSSDITPNAMDTEFSASSPASLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDKEQCAEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:34004147, PubMed:39504960). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:34004147, PubMed:38570683, PubMed:39504960). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS6 acts as a molecular adapter that promotes assembly of protein phosphatase 2A (PP2A) subunits to the integrator core complex, promoting recruitment of PP2A to transcription pause-release checkpoint (PubMed:33243860, PubMed:34004147). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144). {ECO:0000269|PubMed:15254679, ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:38570683, ECO:0000269|PubMed:39504960}.
uniprot
proteins
mass_dalton
100390
uniprot
proteins
protein_family
Integrator subunit 6 family
uniprot
proteins
pubmed
10467397
uniprot
proteins
pubmed
11939413
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15254679
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16007164
uniprot
proteins
pubmed
16239144
uniprot
proteins
pubmed
16271964
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23904267
uniprot
proteins
pubmed
33243860
uniprot
proteins
pubmed
34004147
uniprot
proteins
pubmed
34762484
uniprot
proteins
pubmed
36869814
uniprot
proteins
pubmed
38570683
uniprot
proteins
pubmed
39032490
uniprot
proteins
pubmed
39504960
uniprot
proteins
sequence_length
887
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11939413, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:39032490}. Chromosome {ECO:0000269|PubMed:34004147}. Note=Associates with chromatin and transcription pause-release checkpoint. {ECO:0000269|PubMed:34004147}.
uniprot
proteins