DKK3
entrez
27122
canonical
uniprot
Q9UBP4
canonical
ensembl
ENSG00000050165
resolver
ensp
ENSP00000314910
resolver
ensp
ENSP00000379762
resolver
ensp
ENSP00000433112
resolver
ensp
ENSP00000506835
resolver
ensp
ENSP00000573574
resolver
ensp
ENSP00000573575
resolver
ensp
ENSP00000573577
resolver
ensp
ENSP00000573581
resolver
ensp
ENSP00000573582
resolver
ensp
ENSP00000601349
resolver
ensp
ENSP00000601353
resolver
ensp
ENSP00000628848
resolver
ensp
ENSP00000628854
resolver
ensp
ENSP00000628856
resolver
ensp
ENSP00000628859
resolver
ensp
ENSP00000628865
resolver
ensp
ENSP00000628871
resolver
ensp
ENSP00000628873
resolver
enst
ENST00000326932
resolver
enst
ENST00000396505
resolver
enst
ENST00000525493
resolver
enst
ENST00000683431
resolver
enst
ENST00000903515
resolver
enst
ENST00000903516
resolver
enst
ENST00000903518
resolver
enst
ENST00000903522
resolver
enst
ENST00000903523
resolver
enst
ENST00000931290
resolver
enst
ENST00000931294
resolver
enst
ENST00000958789
resolver
enst
ENST00000958795
resolver
enst
ENST00000958797
resolver
enst
ENST00000958800
resolver
enst
ENST00000958812
resolver
enst
ENST00000958814
resolver
genesymbol
DKK3
resolver
genesymbol_syn
REIC
resolver
hgnc
HGNC:2893
resolver
uniprot
A8K1I2
resolver
uniprot
D3DQW1
resolver
uniprot
F6SYF8
resolver
uniprot
Q9ULB7
resolver
uniprot_entry
DKK3_HUMAN
resolver
uniprot_entry
F6SYF8_HUMAN
resolver
uniprot_sec
A8K1I2
resolver
uniprot_sec
D3DQW1
resolver
uniprot_sec
Q9ULB7
resolver
amino_acid_sequence
MQRLGATLLCLLLAAAVPTAPAPAPTATSAPVKPGPALSYPQEEATLNEMFREVEELMEDTQHKLRSAVEEMEAEEAAAKASSEVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITNNQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPCASGLLCQPHSHSLVYVCKPTFVGSRDQDGEILLPREVPDEYEVGSFMEEVRQELEDLERSLTEEMALREPAAAAAALLGGEEI
uniprot
proteins
function
FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
38390
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated. {ECO:0000269|PubMed:10570958, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:23234360}.
uniprot
proteins
protein_family
Dickkopf family
uniprot
proteins
pubmed
10570958
uniprot
proteins
pubmed
10652205
uniprot
proteins
pubmed
11814687
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17143291
uniprot
proteins
pubmed
19838169
uniprot
proteins
pubmed
23234360
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins