HK2
entrez
3099
canonical
uniprot
P52789
canonical
ensembl
ENSG00000159399
resolver
ensp
ENSP00000290573
resolver
ensp
ENSP00000387140
resolver
ensp
ENSP00000637978
resolver
ensp
ENSP00000700909
resolver
enst
ENST00000290573
resolver
enst
ENST00000409174
resolver
genesymbol
HK2
resolver
hgnc
HGNC:4923
resolver
uniprot
D6W5J2
resolver
uniprot
E9PB90
resolver
uniprot
Q8WU87
resolver
uniprot
Q9UN82
resolver
uniprot_entry
E9PB90_HUMAN
resolver
uniprot_entry
HXK2_HUMAN
resolver
uniprot_sec
D6W5J2
resolver
uniprot_sec
Q8WU87
resolver
uniprot_sec
Q9UN82
resolver
activity_regulation
ACTIVITY REGULATION: Hexokinase activity is specifically inhibited by 2,6-disubstituted glucosamines. {ECO:0000269|PubMed:26985301}.
uniprot
proteins
amino_acid_sequence
MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIREAGQR
uniprot
proteins
ec_number
2.7.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}.
uniprot
proteins
mass_dalton
102380
uniprot
proteins
mutagenesis
MUTAGEN 209; /note="D->A: Decreased hexokinase activity."; /evidence="ECO:0000269|PubMed:29298880"; MUTAGEN 468; /note="R->A: Induces a rapid dissociation of D-glucose."; /evidence="ECO:0000269|PubMed:29298880"; MUTAGEN 657; /note="D->A: Decreased hexokinase activity."; /evidence="ECO:0000269|PubMed:29298880
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate metabolism; hexose metabolism. {ECO:0000305|PubMed:29298880}.; PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4. {ECO:0000305|PubMed:29298880}.
uniprot
proteins
protein_family
Hexokinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18350175
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23185017
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26985301
uniprot
proteins
pubmed
29298880
uniprot
proteins
pubmed
7518342
uniprot
proteins
pubmed
7883120
uniprot
proteins
pubmed
7883122
uniprot
proteins
pubmed
7883123
uniprot
proteins
pubmed
8250948
uniprot
proteins
pubmed
8786021
uniprot
proteins
sequence_length
917
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18350175}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:18350175}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880). The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein (PubMed:29298880). Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:29298880}.
uniprot
proteins