Exosc10
entrez
313707
canonical
uniprot
D4A1X2
canonical
ensembl
ENSRNOG00000010719
resolver
ensembl
ENSRNOG00055022921
resolver
ensembl
ENSRNOG00060030537
resolver
ensembl
ENSRNOG00065010792
resolver
ensp
ENSRNOP00000014629
resolver
ensp
ENSRNOP00055031987
resolver
ensp
ENSRNOP00060044228
resolver
ensp
ENSRNOP00065013452
resolver
enst
ENSRNOT00000014629
resolver
enst
ENSRNOT00055039411
resolver
enst
ENSRNOT00060053191
resolver
enst
ENSRNOT00065017522
resolver
genesymbol
Exosc10
resolver
uniprot_entry
EXOSX_RAT
resolver
amino_acid_sequence
MAPPSPREHQSAPATGATKPDAEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQVGDEYDFYRSFPAFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSKVTELEDKFDLLVDTNDVILERVGILLDEASGVNKHQQPVLPAGLQVPKTIVSSWNRKAGEYGKKAKAETFRLLHAKNILRPQLRFREKIDNSNTPFLPKIFVKPNARKPLPQALSKERRERPQDRPEDLDVPPALADFIHQQRAQQVEQDVFAHPYQYELDHFTPPPSVLQRPQPQLYRPVEETPCHVVSSLDELVELNEKLLGCQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIVDTLELRSDMYILNESLTDPAIVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLARHSLDHLLRLYCGVESNKQYQLADWRIRPLPEEMLNYARDDTHYLLYIYDRMRLELWERGNDQPVQLQVVWQRSRDICLKKFVKPIFTDESYLELYRKQKKHLNSQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLLKSETAAGVKKSGPLPSAERLENDLFGPHDCSHAPPDNYPVTSTDGTMPLQKQPSLFDEGKEETSVDARCLLATAVITLFSEPSTEEAGKTPLTVAQKKAQSIMESFENPFRMFLPSLENKAHISQAAKFDPSSKIYEISNRWKLASQVQKEPKEAAKKKVAEQTAAREETKEESTAAVLEQPIPVRQQAALENATKKRERATSDLRTIEQKQEKKRLKSSKKAKDPDPPGKDFSPYDYSQSDFGAFAGDSKSKPSSQFDPNKVAPSGKKCFGAKKFKQSVGNKSMSFPAGKSDRGFRHNWPKR
uniprot
proteins
ec_number
3.1.13.-
uniprot
proteins
function
FUNCTION: Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA (By similarity). Plays a role in the recruitment of replication protein A complex (RPA) and RAD51 to DNA double-strand breaks caused by irradiation, contributing to DNA repair by homologous recombination (By similarity). Regulates levels of damage-induced RNAs in order to prevent DNA-RNA hybrid formation at DNA double-strand breaks and limit DNA end resection after damage (By similarity). Plays a role in oocyte development, maturation and survival (By similarity). Required for normal testis development and mitotic division of spermatogonia (By similarity). Plays a role in proper embryo development (By similarity). Required for global protein translation (By similarity). Required for cell proliferation (By similarity). {ECO:0000250|UniProtKB:P56960, ECO:0000250|UniProtKB:Q01780}.
uniprot
proteins
mass_dalton
100719
uniprot
proteins
post_translational_modification
PTM: Sumoylated by USP36; sumoylation does not significantly affect EXOSC10 nucleolar localization and association with core exosome and USP36, but regulates the nucleolar RNA exosome activity in rRNA processing by promoting binding of EXOSC10 to pre-rRNAs. Effects of sumoylation on EXOSC10 levels vary between different studies. Sumoylation of EXOSC10 is required for the modulation of EXOSC10 effects on cellular protein translation and cell proliferation. Sumoylation is promoted by mild hypothermia. {ECO:0000250|UniProtKB:Q01780}.
uniprot
proteins
protein_family
Exosome component 10/RRP6 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
29118343
uniprot
proteins
sequence_length
885
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q01780}. Nucleus {ECO:0000250|UniProtKB:Q01780}. Nucleus, nucleolus {ECO:0000269|PubMed:29118343}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q01780}. Note=Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. {ECO:0000250|UniProtKB:Q01780}.
uniprot
proteins