CES2
entrez
8824
canonical
uniprot
O00748
canonical
ensembl
ENSG00000172831
resolver
ensp
ENSP00000317842
resolver
ensp
ENSP00000394452
resolver
ensp
ENSP00000806558
resolver
genesymbol
CES2
resolver
genesymbol_syn
ICE
resolver
hgnc
HGNC:1864
resolver
uniprot
A0A024R6X1
resolver
uniprot
A8K367
resolver
uniprot
Q16859
resolver
uniprot
Q5MAB8
resolver
uniprot
Q7Z366
resolver
uniprot
Q8IUP4
resolver
uniprot
Q8TCP8
resolver
uniprot_entry
EST2_HUMAN
resolver
uniprot_sec
A0A024R6X1
resolver
uniprot_sec
A8K367
resolver
uniprot_sec
Q16859
resolver
uniprot_sec
Q5MAB8
resolver
uniprot_sec
Q7Z366
resolver
uniprot_sec
Q8IUP4
resolver
uniprot_sec
Q8TCP8
resolver
amino_acid_sequence
MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL
uniprot
proteins
ec_number
3.1.1.1
uniprot
proteins
ec_number
3.1.1.56
uniprot
proteins
ec_number
3.1.1.84
uniprot
proteins
function
FUNCTION: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984). {ECO:0000269|PubMed:21049984, ECO:0000269|PubMed:9169443, ECO:0000303|PubMed:28677105}.
uniprot
proteins
mass_dalton
61807
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:9169443}.
uniprot
proteins
protein_family
Type-B carboxylesterase/lipase family
uniprot
proteins
pubmed
12721789
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
15618752
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21049984
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22446793
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28677105
uniprot
proteins
pubmed
9144407
uniprot
proteins
pubmed
9169443
uniprot
proteins
sequence_length
559
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:22446793}.
uniprot
proteins