Fbh1
entrez
50755
canonical
uniprot
Q8K2I9
canonical
ensembl
ENSMUSG00000058594
resolver
ensp
ENSMUSP00000071495
resolver
ensp
ENSMUSP00000250429
resolver
genesymbol
Fbh1
resolver
genesymbol_syn
Fbx18
resolver
genesymbol_syn
Fbxo18
resolver
uniprot
Q3UGP2
resolver
uniprot
Q8C444
resolver
uniprot
Q99KS0
resolver
uniprot
Q9CTC6
resolver
uniprot
Q9QZG7
resolver
uniprot_entry
FBH1_MOUSE
resolver
uniprot_entry
Q3UGP2_MOUSE
resolver
uniprot_sec
Q8C444
resolver
uniprot_sec
Q99KS0
resolver
uniprot_sec
Q9CTC6
resolver
uniprot_sec
Q9QZG7
resolver
amino_acid_sequence
MRRFKRKHLTVVDCHHLARSHLAVTQPFSQRWTNRDPNHGLYPRPRTKGRNRGRGCQRYISEFFLAGHQHCTNDMAKSNSVGQDSCQDAEGDMILTAESSCTLPQVDNGEARLGSSGSAQPARKRAHCFEEATESGQWDGVTKKTPRHRLFPSCSRLREARQGAEDSLSQCSPVPGEAGRDIEDIGPDPLPDSYYGLLGMLPCQEVPSHICRLPSEVLRHIFAFLPVEDLYWNLSLVCHLWREIINDPLFIPWKKLYHRYLINEEQAVSKVDGILSSHGIEKDSDLCVLNLIRYTATTKCSPSVDPERVLWSLRDHPLLLEAEACMRQQLPDLYAAAGGINVWALVAAMVLLSSCVNDIQHLLFCLRRPSSTVTMPDVTETLYCIAVLLYAMREKGINISNRIHYNIFYCLYLQENSCTQATKVTEEPSVWPGKKTSIQLTHEQQLILNHKMEPLQVVKIMAFAGTGKTSTLVKYAEKWSQSRFLYVTFNKSIAKQAELVFPSNVICKTFHSMAYSHVGRKYQLKKKLNLFKLTPFMVNSVLAEGKGGFIRAKLVCKTLENFFASADEELTIDHVPIWCKNSHGQRVMVEQSEKLNGVLEASRLWDNMRKLGECKEEAYQMTHDGYLKLWQLSKPLLASFDAIFVDEAQDCTPAIMNIVLSQPCGKIFVGDPHQQIYTFRGAVNALFTVPHTHVFYLTQSFRFGVEIAYVGATILDVCKRVRKKTLVGGNHQSGIRGDIKGQVALLSRTNANVFDEAVRVTEGESPARIHLIGGIKSFGLDRIIDIWTLLQPEEERRKRDLIIKDRFIRRWVHKEGFSGFKRYVTAAEDKELEAKIAVVEKYNIRIPELVERIERCHIDDLDFAEYILGTVHKAKGLEFDTVHVLDDFVKVPCARHNLAQLPHFRVESFSEDEWNLLYVAVTRAKKRLIMTKSLENILTLAGEYFLQAELTSNVLKTGVVHCCVGQCNNTIPVDTILTMKKLPITYSNRKENKGGYLCHSCAEQRIGPLAFLTASPEQVRAMERTVEDIVLPRQEALLFLVF
uniprot
proteins
ec_number
5.6.2.4
uniprot
proteins
function
FUNCTION: 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:24108124). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress. Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal. In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (By similarity). {ECO:0000250|UniProtKB:Q8NFZ0, ECO:0000269|PubMed:24108124}.
uniprot
proteins
mass_dalton
118298
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8NFZ0}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination by the DCX(DTL) complex, also named CRL4(CDT2), leading to its degradation: ubiquitination takes place after its localization to DNA damage sites, possibly to facilitate the translesion synthesis (TLS) pathway. {ECO:0000250|UniProtKB:Q8NFZ0}.
uniprot
proteins
protein_family
Helicase family
uniprot
proteins
protein_family
UvrD subfamily
uniprot
proteins
pubmed
10531037
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24108124
uniprot
proteins
sequence_length
1042
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8NFZ0}. Chromosome {ECO:0000250|UniProtKB:Q8NFZ0}. Note=Accumulates at sites of DNA damage or replication stress. PCNA is required for localization to DNA damage sites. Localizes to the nucleoplasm in absence of DNA damage. {ECO:0000250|UniProtKB:Q8NFZ0}.
uniprot
proteins