Fmo3
entrez
14262
canonical
uniprot
P97501
canonical
ensembl
ENSMUSG00000026691
resolver
ensp
ENSMUSP00000028010
resolver
enst
ENSMUST00000028010
resolver
genesymbol
Fmo3
resolver
uniprot
Q3UEN4
resolver
uniprot
Q8C7J1
resolver
uniprot_entry
FMO3_MOUSE
resolver
uniprot_entry
Q3UEN4_MOUSE
resolver
uniprot_entry
Q8C7J1_MOUSE
resolver
amino_acid_sequence
MKKKVAIIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWKFSDHIEEGRASIYQSVFTNSSKEMMCFPDFPYPDDFPNFMHHSKLQEYITSFAKEKNLLKYIQFETPVTSINKCPNFSTTGKWEVTTEKHGKKETAVFDATMICSGHHIFPHVPKDSFPGLNRFKGKCFHSRDYKEPGIWKGKRVLVIGLGNSGCDIAAELSHVAQKVTISSRSGSWVMSRVWDDGYPWDMVVLTRFQTFLKNNLPTAISDWWYTRQMNARFKHENYGLVPLNRTLRKEPVFNDELPARILCGMVTIKPNVKEFTETSAVFEDGTMFEAIDCVIFATGYGYAYPFLDDSIIKSRNNEVTLYKGVFPPQLEKPTMAVIGLVQSLGATIPITDLQARWAAQVIKGTCTLPSVNDMMDDIDEKMGEKFKWYGNSTTIQTDYIVYMDELASFIGAKPNLLWLFLKDPRLAVEVFFGPCSPYQFRLVGPGKWSGARNAILTQWDRSLKPMKTRVVSKVQKSCSHFYSRLLRLLAVPVLLIALFLVLI
uniprot
proteins
ec_number
1.14.13.148
uniprot
proteins
ec_number
1.14.13.32
uniprot
proteins
ec_number
1.14.13.8
uniprot
proteins
function
FUNCTION: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation. {ECO:0000250|UniProtKB:P31513, ECO:0000269|PubMed:23177478}.
uniprot
proteins
mass_dalton
60516
uniprot
proteins
protein_family
FMO family
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23177478
uniprot
proteins
pubmed
9344459
uniprot
proteins
sequence_length
534
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:P32417}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P32417}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 514..534; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins