Mettl4
entrez
76781
canonical
uniprot
Q3U034
canonical
ensembl
ENSMUSG00000055660
resolver
ensp
ENSMUSP00000127142
resolver
ensp
ENSMUSP00000157180
resolver
ensp
ENSMUSP00000315746
resolver
ensp
ENSMUSP00000315747
resolver
ensp
ENSMUSP00000338282
resolver
enst
ENSMUST00000171284
resolver
enst
ENSMUST00000234990
resolver
genesymbol
Mettl4
resolver
uniprot
A0A452J8K3
resolver
uniprot
A4FTY8
resolver
uniprot_entry
A0A452J8K3_MOUSE
resolver
uniprot_entry
A4FTY8_MOUSE
resolver
uniprot_entry
METL4_MOUSE
resolver
amino_acid_sequence
MSVVHHLPPGWLLDHLSFINKVNYQLCQHQESFCSKNNPTSSVYMDSLQLDPGSPFGAPAMCFAPDFTTVSGNDDEGSCEVITEKYVFRSELFNVTKPYIVPAVHKERQQSNKNENLVTDYKQEVSVSVGKKRKRCIAFNQGELDAMEYHTKIRELILDGSSKLIQEGLRSGFLYPLVEKQDGSSGCITLPLDACNLSELCEMAKHLPSLNEMELQTLQLMGDDVSVIELDLSSQIIENNSSFSKMITLMGQKYLLPPQSSFLLSDISCMQPLLNCGKTFDAIVIDPPWENKSVKRSNRYSSLSPQQIKRMPIPKLAAADCLIVTWVTNRQKHLCFVKEELYPSWSVEVVAEWYWVKITNSGEFVFPLDSPHKKPYECLVLGRVKEKTPLALRNPDVRIPPVPDQKLIVSVPCVLHSHKPPLTEVLRDYIKPGGQCLELFARNLQPGWMSWGNEVLKFQHMDYFIALESGC
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.72
uniprot
proteins
function
FUNCTION: N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA (PubMed:30982744). Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U2 small nuclear RNA (snRNA): methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation (By similarity). Internal m6A(m) methylation of snRNAs regulates RNA splicing (By similarity). Also able to act as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (PubMed:30982744). The existence of N(6)-methyladenosine (m6A) on DNA is however unclear in mammals, and additional evidence is required to confirm the role of the N(6)-adenine-specific DNA methyltransferase activity of METTL4 in vivo (By similarity). Acts as a regulator of mitochondrial transcript levels and mitochondrial DNA (mtDNA) copy number by mediating mtDNA N(6)-methylation: m6A on mtDNA reduces transcription by repressing TFAM DNA-binding and bending (By similarity). N(6)-methyladenosine deposition by METTL4 regulates Polycomb silencing by triggering ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (PubMed:30982744). {ECO:0000250|UniProtKB:Q8N3J2, ECO:0000269|PubMed:30982744}.
uniprot
proteins
mass_dalton
53306
uniprot
proteins
mutagenesis
MUTAGEN 287..288; /note="PP->RR: Abolished methyltransferase activity."; /evidence="ECO:0000269|PubMed:30982744
uniprot
proteins
protein_family
MT-A70-like family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
30982744
uniprot
proteins
sequence_length
471
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N3J2}.
uniprot
proteins