Grik3
entrez
14807
canonical
uniprot
B1AS29
canonical
ensembl
ENSMUSG00000001985
resolver
ensp
ENSMUSP00000030676
resolver
enst
ENSMUST00000030676
resolver
genesymbol
Grik3
resolver
genesymbol_syn
Glur7
resolver
uniprot
Q17R20
resolver
uniprot
Q9JIA8
resolver
uniprot_entry
GRIK3_MOUSE
resolver
uniprot_sec
Q17R20
resolver
uniprot_sec
Q9JIA8
resolver
activity_regulation
ACTIVITY REGULATION: Glutamate-gated receptor activity inhibited by spermine. {ECO:0000269|PubMed:20007474}.
uniprot
proteins
amino_acid_sequence
MTAPWRRLRSLVWEYWAGFLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWAMERLQAAPRAESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKTAEREQRSFCSTVADEIRFSLTCQRRLKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMSCSTSLAPVFP
uniprot
proteins
function
FUNCTION: Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:17620617, PubMed:20007474). In association with GRIK2, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (PubMed:17620617). {ECO:0000269|PubMed:17620617, ECO:0000269|PubMed:20007474}.
uniprot
proteins
mass_dalton
104051
uniprot
proteins
mutagenesis
MUTAGEN 618; /note="M->V: Loss of spermine-binding; when associated with A-620."; /evidence="ECO:0000269|PubMed:20007474"; MUTAGEN 620; /note="S->A: Loss of spermine-binding; when associated with V-618."; /evidence="ECO:0000269|PubMed:20007474
uniprot
proteins
protein_family
GRIK3 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
11124978
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17620617
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20007474
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
919
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17620617}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P42264}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 564..584; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 637..657; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 821..841; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins