Bach1
entrez
12013
canonical
uniprot
P97302
canonical
ensembl
ENSMUSG00000025612
resolver
ensp
ENSMUSP00000026703
resolver
enst
ENSMUST00000026703
resolver
genesymbol
Bach1
resolver
uniprot
Q3URL4
resolver
uniprot
Q3US24
resolver
uniprot_entry
BACH1_MOUSE
resolver
uniprot_entry
Q3URL4_MOUSE
resolver
uniprot_entry
Q3US24_MOUSE
resolver
amino_acid_sequence
MSVSESAVFAYESSVHSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQTDAELTVTLPEEVTVKGFEPLIQFAYTAKLILSKDNVDEVCRCVEFLSVHNIEESCFQFLKFKFLDSTSEQQECARKKCFSSHCQKADFKFSFSEQKDLEIDEADEFLEKKRVQTPQCDSRRCQGSVKASPPLQDSVSQACQSLCTDKDGALALPSLCPKYRKFQKAFGTDKIRTLESGVRDVHTASVQPNETSELECFGGAQGCADLHVILKCEGMKAAMESEDTEGQDPSPQCPAEQPQGTPLPQDSAGPHGLYSLSALHTYEQSGDVAFAGVQSKTVKTEKPLSRPDAQDEKPSENQDLYLKSSMGPKEDSSSLASEDRSSVEREVAEHLAKGFWSDICSTDSPCQMQLSPTVAKDGPEQGYSQRRSECPWLGIRISESPEPGQRTFTTLSSVNCPFISTLSSEGCSSNLEIGNYDYVSEPQQEPCPYACVISLGDDSETDTEGDSESCSAREQDCEVKLPFNAQRIISLSRNDFQSLLKMHKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLCQQVCKEAALSPEQIQILAKYSASDCPLSFLISEKGKSTPDGELAFTSVFSVSDVPPTAPPPCGRGSSAASQELVQESPPTTAAAPEQATLLEPCRQSAGISDFCQQMSDKCTTDE
uniprot
proteins
function
FUNCTION: Transcriptional regulator that acts as a repressor or activator, depending on the context (PubMed:19170764, PubMed:8887638). Binds to NF-E2 DNA binding sites (PubMed:19170764, PubMed:8887638). Plays important roles in coordinating transcription activation and repression by MAFK (PubMed:8887638). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (By similarity). {ECO:0000250|UniProtKB:O14867, ECO:0000269|PubMed:19170764, ECO:0000269|PubMed:8887638}.
uniprot
proteins
mass_dalton
81374
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF(FBXL17) complex or by the by the SCF(FBXO22) complex, leading to its degradation by the proteasome. Under oxidative stress, reactive oxygen species covalently modify cysteine residues on the bZIP domain of BACH1 and release it from chromatin. If the BTB domain of BACH1 remains intact, its beta1-alpha6 degron is recognized by FBXO22, promoting its ubiquitination and degradation. If the structural integrity of the beta1-alpha6 degron is compromised, FBXL17 will transiently associate with the BACH1 BTB dimer and remodel it into stably bound monomer for ubiquitination and degradation. {ECO:0000250|UniProtKB:O14867}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
CNC subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19170764
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8887638
uniprot
proteins
sequence_length
739
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:8887638}.
uniprot
proteins