Cdon
entrez
57810
canonical
uniprot
Q32MD9
canonical
ensembl
ENSMUSG00000038119
resolver
ensp
ENSMUSP00000045547
resolver
ensp
ENSMUSP00000113977
resolver
ensp
ENSMUSP00000117499
resolver
ensp
ENSMUSP00000306064
resolver
enst
ENSMUST00000042842
resolver
enst
ENSMUST00000119129
resolver
genesymbol
Cdon
resolver
genesymbol_syn
Cdo
resolver
uniprot
E9QKV9
resolver
uniprot
O88971
resolver
uniprot_entry
CDON_MOUSE
resolver
uniprot_sec
E9QKV9
resolver
uniprot_sec
O88971
resolver
amino_acid_sequence
MHPDLGPLWTLLYVLVILCSSVSSDLAPYFISEPLSAVQKLGRPVVLHCSAKPVTARISWLHNGKRLDRNTEQIKIHRGTLTILSLNPSLSGCYQCVANNSVGAVVSGPATVSAAALGDFDSSTMHVITAEEKNTGFIGCRVPESNPKAEVRYKIRGKWLKHSTGNYIILPSGNLQVLNVSSKDKGSYKCAAYNPVTSELKVEPTGRKLLVSRPSSNGFHILHPALSQALAVLPHSPVTLECVVSGVPASQVYWLKDGQDAVAGSNWRRLYSHLATASIDPADSGNYSCVVGNKSGDVKHVTYMVNVLEHASISKGLHDQKVSLGATVHFTCDVHGNPAPNRTWFHNAQPIHPSSRHLTEGNVLKITRVVMEDSGLYQCVADNGIGFMQSTGRLQIEQDSGWKPVIVTAPANIEVMDGDFVTLSCNATGVPVPVIHWYGRHGLITSHPSQVLRSKPRKSHLFRPGDLDLEPVYLIMSQAGSSSLSIQAVTLEHAGKYTCEATNKHGSTQSEAFLTVVPFETNTKAESVTPSEASQNDERDPQDGSESSLLNLFPVKVHPSGVELPAERNASVPDAPNILSPPQTHMPDTYNLVWRAGRDGGMPINAYFVKYRKLDDGSGAVGSWHTVRVPGSENELHLTELEPSSLYEVLMVARSAVGEGQPAMLTFRTSKEKMASSKNTQASFPPVGVPKRPVTAEASNSNFGVVLTDSSRHSGVPEAPDRPTISMASETSVYVTWIPRANGGSPITAFKVEYKRMRTSDWLVAAEDIPPSKLSVEVRSLEPGSIYKFRVIAINHYGESFRSSASRPYQVAGFPNRFSNRPITGPHIAYTEAVSDTQIMLKWTYVPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHTIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASDYPVKELSTPPSSSGNAGNVGPATSPARSSDMLYLIVGCVLGVMVLILMVFIALCLWKSRQQSTIQKYDPPGYLYQGSEINGQMVEYTTLSGAARINGSVHGGFLSNGCSHLHHKGPSGVNGTLSGNINGGLYSAHTNSLTRACVEFEHPHHLVNSGGVYTAVPQMDPLECINCRNCRNNNRCFTKTNSPLPVVPVVASYPQGGLEMKPLNAMKVPVCPASTVPDHGQLPDDCVKDSVAPIPTQHTCCQDNISDINSDSTEDTAEFSRGDSSGHSEAEDKVFSWNPLILSPVLEDCGEKTARSPPGPPLDGLSVVLQQAQET
uniprot
proteins
function
FUNCTION: Together with BOC, forms a coreceptor required for sonic hedgehog (SHH) handoff to its patched receptor (PTCH1 or PTCH2), thereby allowing activation of the smoothened signaling pathway (PubMed:16647303, PubMed:16647304, PubMed:21664576, PubMed:33038332). Binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) downstream of SCUBE2 carrier and promotes its release to GAS1 (PubMed:33038332). ShhN is then directly transferred to patched receptor by GAS1 (PubMed:33038332). May also mediate cell-cell interactions between muscle precursor cells, promoting differentiation of myogenic cells (PubMed:9786951). Required for response to NTN3 and activation of NFATC3 (PubMed:15520228). {ECO:0000269|PubMed:15520228, ECO:0000269|PubMed:16647303, ECO:0000269|PubMed:16647304, ECO:0000269|PubMed:21664576, ECO:0000269|PubMed:33038332, ECO:0000269|PubMed:9786951}.
uniprot
proteins
mass_dalton
135422
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15520228
uniprot
proteins
pubmed
16647303
uniprot
proteins
pubmed
16647304
uniprot
proteins
pubmed
16648472
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21664576
uniprot
proteins
pubmed
33038332
uniprot
proteins
pubmed
9786951
uniprot
proteins
sequence_length
1250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O35158}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 963..983; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins