Gpr75
entrez
237716
canonical
uniprot
Q6X632
canonical
ensembl
ENSMUSG00000043999
resolver
ensp
ENSMUSP00000105057
resolver
ensp
ENSMUSP00000243742
resolver
enst
ENSMUST00000109430
resolver
genesymbol
Gpr75
resolver
uniprot
Q059L0
resolver
uniprot
Q3URC1
resolver
uniprot
Q8BXP3
resolver
uniprot_entry
GPR75_MOUSE
resolver
uniprot_entry
Q059L0_MOUSE
resolver
uniprot_sec
Q3URC1
resolver
uniprot_sec
Q8BXP3
resolver
amino_acid_sequence
MNTSAPLQNVPNATLLNMPPLHGGNSTSLQEGLRDFIHTATLVTCTFLLAIIFCLGSYGNFIVFLSFFDPSFRKFRTNFDFMILNLSFCDLFICGVTAPMFTFVLFFSSASSIPDSFCFTFHLTSSGFVIMSLKMVAVIALHRLRMVMGKQPNCTASFSCILLLTLLLWATSFTLATLATLRTNKSHLCLPMSSLMDGEGKAILSLYVVDFTFCVAVVSVSYIMIAQTLRKNAQVKKCPPVITVDASRPQPFMGASVKGNGDPIQCTMPALYRNQNYNKLQHSQTHGYTKNINQMPIPSASRLQLVSAINFSTAKDSKAVVTCVVIVLSVLVCCLPLGISLVQMVLSDNGSFILYQFELFGFTLIFFKSGLNPFIYSRNSAGLRRKVLWCLRYTGLGFLCCKQKTRLRAMGKGNLEINRNKSSHHETNSAYMLSPKPQRKFVDQACGPSHSKESAASPKVSAGHQPCGQSSSTPINTRIEPYYSIYNSSPSQQESGPANLPPVNSFGFASSYIAMHYYTTNDLMQEYDSTSAKQIPIPSV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. {ECO:0000269|PubMed:17001303, ECO:0000303|PubMed:23979485}.
uniprot
proteins
mass_dalton
59531
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17001303
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23979485
uniprot
proteins
sequence_length
540
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000305|PubMed:17001303}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..67; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 121..141; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 206..226; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 319..339; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 351..371; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins