NLGN3
entrez
54413
canonical
uniprot
Q9NZ94
canonical
ensembl
ENSG00000196338
resolver
ensp
ENSP00000351591
resolver
ensp
ENSP00000363163
resolver
ensp
ENSP00000445298
resolver
ensp
ENSP00000508700
resolver
ensp
ENSP00000508912
resolver
ensp
ENSP00000509202
resolver
ensp
ENSP00000509531
resolver
ensp
ENSP00000574746
resolver
ensp
ENSP00000787242
resolver
enst
ENST00000687220
resolver
enst
ENST00000688566
resolver
enst
ENST00000690133
resolver
enst
ENST00000692338
resolver
genesymbol
NLGN3
resolver
genesymbol_syn
KIAA1480
resolver
genesymbol_syn
NL3
resolver
hgnc
HGNC:14289
resolver
uniprot
A0A8I5KSB7
resolver
uniprot
A0A8I5QJH8
resolver
uniprot
B2RBK1
resolver
uniprot
B7Z3P8
resolver
uniprot
D2X2H6
resolver
uniprot
D3DVV0
resolver
uniprot
D3DVV1
resolver
uniprot
Q4G160
resolver
uniprot
Q86V51
resolver
uniprot
Q8NCD0
resolver
uniprot
Q9NZ95
resolver
uniprot
Q9NZ96
resolver
uniprot
Q9NZ97
resolver
uniprot
Q9P248
resolver
uniprot
X5D2P6
resolver
uniprot
X5D7L6
resolver
uniprot
X5DNV3
resolver
uniprot_entry
A0A8I5KSB7_HUMAN
resolver
uniprot_entry
A0A8I5QJH8_HUMAN
resolver
uniprot_entry
B7Z3P8_HUMAN
resolver
uniprot_entry
NLGN3_HUMAN
resolver
uniprot_entry
Q4G160_HUMAN
resolver
uniprot_entry
X5D2P6_HUMAN
resolver
uniprot_entry
X5D7L6_HUMAN
resolver
uniprot_entry
X5DNV3_HUMAN
resolver
uniprot_sec
B2RBK1
resolver
uniprot_sec
D2X2H6
resolver
uniprot_sec
D3DVV0
resolver
uniprot_sec
D3DVV1
resolver
uniprot_sec
Q86V51
resolver
uniprot_sec
Q8NCD0
resolver
uniprot_sec
Q9NZ95
resolver
uniprot_sec
Q9NZ96
resolver
uniprot_sec
Q9NZ97
resolver
uniprot_sec
Q9P248
resolver
amino_acid_sequence
MWLRLGPPSLSLSPKPTVGRSLCLTLWFLSLALRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAQGSWNGDQDAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGAGAPELGAAPEEELAALQLGPTHHECEAGPPHDTLRLTALPDYTLTLRRSPDDIPLMTPNTITMIPNSLVGLQTLHPYNTFAAGFNSTGLPHSHSTTRV
uniprot
proteins
disease_involvement
DISEASE: Autism, X-linked 1 (AUTSX1) [MIM:300425]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate intellectual disability. {ECO:0000269|PubMed:12669065}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity). {ECO:0000250, ECO:0000269|PubMed:15620359}.
uniprot
proteins
mass_dalton
93895
uniprot
proteins
post_translational_modification
PTM: N-glycosylated, contains high-mannose, hybrid, complex and sialylated N-glycans. N-glycosylation is essential for localization to synapses, dendrites, and the cell membrane, and enhances its availability for trans-synaptic adhesion. O-glycosylated. {ECO:0000250|UniProtKB:Q8BYM5}.
uniprot
proteins
protein_family
Type-B carboxylesterase/lipase family
uniprot
proteins
pubmed
10767552
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
12669065
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15620359
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
18755801
uniprot
proteins
pubmed
19926856
uniprot
proteins
pubmed
20034102
uniprot
proteins
pubmed
9278515
uniprot
proteins
sequence_length
848
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BYM5}; Single-pass type I membrane protein {ECO:0000255}. Synapse {ECO:0000250|UniProtKB:Q8BYM5}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BYM5}. Note=Detected at both glutamatergic and GABAergic synapses. Localizes to dendritic membrane. {ECO:0000250|UniProtKB:Q8BYM5}.
uniprot
proteins
transmembrane_region
TRANSMEM 710..730; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins