Elovl6
entrez
171402
canonical
uniprot
Q920L6
canonical
ensembl
ENSRNOG00000048949
resolver
ensembl
ENSRNOG00055027369
resolver
ensembl
ENSRNOG00060002609
resolver
ensembl
ENSRNOG00065014253
resolver
ensp
ENSRNOP00000067070
resolver
ensp
ENSRNOP00055038964
resolver
ensp
ENSRNOP00060002945
resolver
ensp
ENSRNOP00065018294
resolver
enst
ENSRNOT00000071270
resolver
enst
ENSRNOT00055047384
resolver
enst
ENSRNOT00060004180
resolver
enst
ENSRNOT00065023521
resolver
genesymbol
Elovl6
resolver
genesymbol_syn
Face
resolver
genesymbol_syn
Lce
resolver
uniprot_entry
ELOV6_RAT
resolver
activity_regulation
ACTIVITY REGULATION: The reaction is stimulated by the presence of HSD17B12, the enzyme catalyzing the second step of the elongation cycle. {ECO:0000250|UniProtKB:Q9H5J4}.
uniprot
proteins
amino_acid_sequence
MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMLYILMTKGLKQSVCDQSFYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVINYLVFNWMQHDNDQCYSHFQNIFWSSLMYLSYLLLFCHFFFEAYIGKVKKATKAE
uniprot
proteins
ec_number
2.3.1.199
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000255|HAMAP-Rule:MF_03206, ECO:0000269|PubMed:12005057, ECO:0000269|PubMed:20228221}.
uniprot
proteins
mass_dalton
31624
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03206, ECO:0000269|PubMed:20228221}.
uniprot
proteins
post_translational_modification
PTM: N-Glycosylated. {ECO:0000255|HAMAP-Rule:MF_03206}.
uniprot
proteins
protein_family
ELO family
uniprot
proteins
protein_family
ELOVL6 subfamily
uniprot
proteins
pubmed
12005057
uniprot
proteins
pubmed
20228221
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03206}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03206}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..51; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03206"; TRANSMEM 70..90; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03206"; TRANSMEM 111..131; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03206"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03206"; TRANSMEM 159..179; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03206"; TRANSMEM 197..217; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03206"; TRANSMEM 234..254; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03206
uniprot
proteins