GUCY1A2
entrez
2977
canonical
uniprot
P33402
canonical
ensembl
ENSG00000152402
resolver
ensp
ENSP00000282249
resolver
ensp
ENSP00000431245
resolver
genesymbol
GUCY1A2
resolver
genesymbol_syn
GUC1A2
resolver
genesymbol_syn
GUCSA2
resolver
hgnc
HGNC:4684
resolver
uniprot
A1L4C4
resolver
uniprot
B7ZLT5
resolver
uniprot_entry
GCYA2_HUMAN
resolver
uniprot_sec
A1L4C4
resolver
uniprot_sec
B7ZLT5
resolver
activity_regulation
ACTIVITY REGULATION: Activated by nitric oxide in the presence of magnesium or manganese ions. {ECO:0000269|PubMed:9742221}.
uniprot
proteins
amino_acid_sequence
MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVNLDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTANILGLKFEEIQKRFGEEFFNICFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKLCSDVSNPGNCSCLTFLIKECENTNIMKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHKVLKFEDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSYNIGTMFLRETSL
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Alpha subunit of soluble guanylate cyclase (sGC), a central enzyme in nitric oxide (NO) signaling. Functions as the main intracellular receptor for NO. Upon NO binding, catalyzes the conversion of GTP to cyclic GMP (cGMP) and thereby transducing NO signal into a ubiquitous intracellular second messenger. {ECO:0000269|PubMed:1683630, ECO:0000269|PubMed:9742221}.; FUNCTION: [Isoform 2]: Acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunit. {ECO:0000269|PubMed:7673142}.
uniprot
proteins
mass_dalton
81750
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
1683630
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
7673142
uniprot
proteins
pubmed
9742221
uniprot
proteins
sequence_length
732
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:9742221}.
uniprot
proteins