E9Q3M5
uniprot
E9Q3M5
canonical
amino_acid_sequence
MKVDEEKAGVKKLDPTSYKRRQPEQDFPSIHIGFPVPSYSQRKSDSKGHLSGLQKVQWSLKPGKPQQELAGPGIRASSQGGAVDFTKRTRSPAAEQLQDILGEEDEAPNPTLFTEMDTLQHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSCSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRKHRHQTKKPIHRSLADIGKSVSTTNRSSARSSSAGPTLHRSTEDLRIRQSTSYGHLCHAQSRSMNDISHTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLVQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKRKSVFSLAEPGQMNGSVGGGGASAGGGGSGGGAGGSGAGGVGSGDEAEMPAMHEIGEELIWTGRFFGGLCLDVKRKLPWFPSDFYDGFHLQSISAVLFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKANGLDYMEFRLWIGLHSAIQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINTDFKPDFITTYKCECVAPDTVNTTTVNASAPLAPNTNTSLYTPLNLTALDWSLLSKKECLSYGGRLLGSSCQFVPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRTLVADFSIVFSILLFCGIDACFGLQTPKLHVPSVIKPTRPDRGWFVAPFGKNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLRKAAGYHLDLFWVGILMALCSFTGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGVMVFILTGISVFLAPILKYIPMPVLYGVFLYMGVASLNGIQFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLALLWILKSTMAAIIFPVMILGLIIVRRLLDLIFSQHDLAWIDNILPEKDKKETDKKKKRRKEVHETAEKEVAMPQFLPPSVVKIPMEGIPSDPQNGIHCVARKRSSSWSYSL
uniprot
proteins
function
FUNCTION: Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. {ECO:0000269|PubMed:18588858}.
uniprot
proteins
mass_dalton
124186
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
18588858
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1116
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9BY07}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q6RI88}; Multi-pass membrane protein {ECO:0000255}. Note=Localized predominantly to the basolateral sinusoidal membrane in hepatocytes. {ECO:0000250|UniProtKB:Q6RI88}.
uniprot
proteins
transmembrane_region
TRANSMEM 516..536; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 559..579; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 601..621; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 632..652; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 731..751; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 769..789; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 820..840; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 866..886; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 923..943; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 946..966; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 988..1008; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1009..1029; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins