Atp6v1h
entrez
108664
canonical
uniprot
Q8BVE3
canonical
ensembl
ENSMUSG00000033793
resolver
ensp
ENSMUSP00000040756
resolver
ensp
ENSMUSP00000141797
resolver
ensp
ENSMUSP00000276126
resolver
ensp
ENSMUSP00000276128
resolver
ensp
ENSMUSP00000276136
resolver
ensp
ENSMUSP00000276137
resolver
ensp
ENSMUSP00000276171
resolver
ensp
ENSMUSP00000276194
resolver
ensp
ENSMUSP00000276195
resolver
enst
ENSMUST00000044369
resolver
enst
ENSMUST00000192698
resolver
genesymbol
Atp6v1h
resolver
uniprot
A0A0A6YX18
resolver
uniprot
Q921X8
resolver
uniprot_entry
A0A0A6YX18_MOUSE
resolver
uniprot_entry
VATH_MOUSE
resolver
uniprot_sec
Q921X8
resolver
amino_acid_sequence
MTKMDIRGAVDAAVPTNIIAAKAAEVRANKVNWQSYLQGQMISAEDCEFIQRFEMKRSSEDKQEMLQTEGSQCAKTFINLMTHISKEQTVQYILTMVDDMLQENHQRVSIFFDYAKRSKSTAWPYFLPMLNRQDPFTVHMAARIIAKLAAWGKELMEGSDLNYYFNWIKTQLSSQKLRGSGVAVETGTISSSDSSQYVQCVAGCLQLMLRVNEYRFAWVEADGVNCIMGVLSNKCGFQLQYQMIFSIWLLAFSPQMCEHLRRYNIIPVLSDILQESVKEKVTRIILAAFRNFLEKSTERETRQEYALAMIQCKVLKQLENLEQQKYDDEDISEDIKFLLEKLGESVQDLSSFDEYSSELKSGRLEWSPVHKSEKFWRENAVRLNEKNYELLKILTKLLEVSDDPQVLAVAAHDVGEYVRHYPRGKRVIEQLGGKQLVMNHMHHEDQQVRYNALLAVQKLMVHNWEYLGKQLQSEQPQTAAARS
uniprot
proteins
function
FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (By similarity). {ECO:0000250|UniProtKB:O46563, ECO:0000250|UniProtKB:P41807, ECO:0000250|UniProtKB:Q9UI12}.
uniprot
proteins
mass_dalton
55855
uniprot
proteins
protein_family
V-ATPase H subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:O46563}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins