Metap2
entrez
56307
canonical
uniprot
O08663
canonical
ensembl
ENSMUSG00000036112
resolver
ensp
ENSMUSP00000048285
resolver
ensp
ENSMUSP00000138006
resolver
enst
ENSMUST00000047910
resolver
enst
ENSMUST00000180840
resolver
genesymbol
Metap2
resolver
genesymbol_syn
METAP2
resolver
genesymbol_syn
Mnpep
resolver
genesymbol_syn
P67eif2
resolver
uniprot
Q58E65
resolver
uniprot_entry
MAP2_MOUSE
resolver
uniprot_entry
Q58E65_MOUSE
resolver
amino_acid_sequence
MAGVEQAASFGGHLNGDLDPDDREEGTSSTAEEAAKKKRRKKKKGKGAVSAVQQELDKESGALVDEVAKQLESQALEEKERDDDDEDGDGDADGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDILLTAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
uniprot
proteins
ec_number
3.4.11.18
uniprot
proteins
function
FUNCTION: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). {ECO:0000255|HAMAP-Rule:MF_03175}.; FUNCTION: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. {ECO:0000255|HAMAP-Rule:MF_03175}.
uniprot
proteins
mass_dalton
52922
uniprot
proteins
post_translational_modification
PTM: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding. {ECO:0000255|HAMAP-Rule:MF_03175}.
uniprot
proteins
protein_family
Methionine aminopeptidase eukaryotic type 2 subfamily
uniprot
proteins
protein_family
Peptidase M24A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Note=About 30% of expressed METAP2 associates with polysomes. {ECO:0000255|HAMAP-Rule:MF_03175}.
uniprot
proteins