Gldn
entrez
315675
canonical
uniprot
Q80WL1
canonical
ensembl
ENSRNOG00000024082
resolver
ensembl
ENSRNOG00055030546
resolver
ensembl
ENSRNOG00060017611
resolver
ensembl
ENSRNOG00065016907
resolver
ensp
ENSRNOP00000029833
resolver
ensp
ENSRNOP00055043797
resolver
ensp
ENSRNOP00060024297
resolver
ensp
ENSRNOP00065022306
resolver
enst
ENSRNOT00000033900
resolver
enst
ENSRNOT00055052997
resolver
enst
ENSRNOT00060030101
resolver
enst
ENSRNOT00065028213
resolver
genesymbol
Gldn
resolver
uniprot
G3V8X4
resolver
uniprot_entry
G3V8X4_RAT
resolver
uniprot_entry
GLDN_RAT
resolver
amino_acid_sequence
MTRAAERGQGATGWGLRGALMAVALLSVLNAVGTVFVLYQWRELSAALRALEAQHGQEQREDSALRAFLAELSRAPARVPEPPQDPMSAARNKRSHGGEPASHIRAESQDMMMMMTYSMVPIRVMIDLCNSTQGICLTGPPGPPGPPGAGGLPGHNGSDGQPGLQGPKGEKGAVGKRGKMGLPGATGNPGEKGEKGDAGELGLPGNEGPPGQKGDKGDKGDVSNDVLLTGAKGDQGPPGPPGPPGPPGPPGSRRAKGPRQPNSFTNQCPGETCVIPNDDTLVGRADEKVNERHSPQTEPMITSIGNPAQVLKVKETFGTWLRESANRSDDRIWVTEHFSGIMVKEFEDLPALLNSSFTLLHLPHYFHGCGHAVYNNSLYYHKGGSNTIVRFEFGKETPQTLKLEDALYFDRKYLFANSKTYFNIAVDEKGLWIIYASSVDGSSILVAQLDERTFSVLRHINTTYPKSKAGNAFIAQGILYVTDTKDTRVTFAFDLLRGKQINANFGLRMSQSVLAMLSYNMRDQHLYSWEDGHLMLYPVHFSSTAPSQR
uniprot
proteins
function
FUNCTION: Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC (PubMed:16039564). Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier (By similarity). {ECO:0000250|UniProtKB:Q8BMF8, ECO:0000269|PubMed:16039564}.
uniprot
proteins
mass_dalton
59330
uniprot
proteins
mutagenesis
MUTAGEN 91; /note="R->G: Abolishes cleavage and shedding of ectodomain; when associated with A-94."; /evidence="ECO:0000269|PubMed:17485493"; MUTAGEN 94; /note="R->A: Abolishes cleavage and shedding of ectodomain; when associated with G-91."; /evidence="ECO:0000269|PubMed:17485493
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:17485493}.; PTM: Proteolytic processing by a furin-like protease causes shedding of the ectodomain (PubMed:17485493). Further cleavage by BMP1 releases the olfactomedin-like domain. {ECO:0000250|UniProtKB:Q8BMF8, ECO:0000269|PubMed:17485493}.
uniprot
proteins
pubmed
16039564
uniprot
proteins
pubmed
17485493
uniprot
proteins
pubmed
22009740
uniprot
proteins
pubmed
25525261
uniprot
proteins
sequence_length
549
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16039564}; Single-pass type II membrane protein {ECO:0000269|PubMed:16039564}. Cell projection, axon {ECO:0000269|PubMed:16039564, ECO:0000269|PubMed:22009740}. Note=Detected at the nodes of Ranvier (PubMed:16039564, PubMed:22009740). Detected at immature heminodes (PubMed:22009740). {ECO:0000269|PubMed:16039564, ECO:0000269|PubMed:22009740}.; SUBCELLULAR LOCATION: [Gliomedin shedded ectodomain]: Secreted {ECO:0000269|PubMed:17485493}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17485493}. Note=Proteolytic processing gives rise to a soluble extracellular domain that is secreted. The gliomedin shedded ectodomain localizes to the nodes of Ranvier. {ECO:0000269|PubMed:17485493}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins