Fabp5
entrez
16592
canonical
uniprot
Q05816
canonical
ensembl
ENSMUSG00000027533
resolver
ensp
ENSMUSP00000029046
resolver
ensp
ENSMUSP00000165474
resolver
ensp
ENSMUSP00000361765
resolver
enst
ENSMUST00000029046
resolver
genesymbol
Fabp5
resolver
genesymbol_syn
Fabpe
resolver
genesymbol_syn
Klbp
resolver
genesymbol_syn
Mal1
resolver
uniprot
Q497I3
resolver
uniprot_entry
FABP5_MOUSE
resolver
uniprot_entry
Q497I3_MOUSE
resolver
amino_acid_sequence
MASLKDLEGKWRLMESHGFEEYMKELGVGLALRKMAAMAKPDCIITCDGNNITVKTESTVKTTVFSCNLGEKFDETTADGRKTETVCTFQDGALVQHQQWDGKESTITRKLKDGKMIVECVMNNATCTRVYEKVQ
uniprot
proteins
function
FUNCTION: Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind (PubMed:12540600, PubMed:8608126). In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (By similarity). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival (PubMed:17512406). May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling (PubMed:29531087). Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (PubMed:29440395). May be involved in keratinocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q01469, ECO:0000269|PubMed:12540600, ECO:0000269|PubMed:17512406, ECO:0000269|PubMed:29440395, ECO:0000269|PubMed:29531087, ECO:0000269|PubMed:8608126}.
uniprot
proteins
mass_dalton
15137
uniprot
proteins
protein_family
Calycin superfamily
uniprot
proteins
protein_family
Fatty-acid binding protein (FABP) family
uniprot
proteins
pubmed
12540600
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17512406
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24531463
uniprot
proteins
pubmed
29440395
uniprot
proteins
pubmed
29531087
uniprot
proteins
pubmed
8349619
uniprot
proteins
pubmed
8608126
uniprot
proteins
pubmed
9666100
uniprot
proteins
pubmed
9795232
uniprot
proteins
sequence_length
135
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17512406, ECO:0000269|PubMed:29531087}. Nucleus {ECO:0000269|PubMed:17512406}. Synapse {ECO:0000269|PubMed:29531087}. Postsynaptic density {ECO:0000269|PubMed:29531087}. Secreted {ECO:0000269|PubMed:29531087}. Note=Localizes primarily to the cytoplasm. Upon certain ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into nucleus (By similarity). Secreted by astrocytes, but not by neurons (PubMed:29531087). {ECO:0000250|UniProtKB:Q01469, ECO:0000269|PubMed:29531087}.
uniprot
proteins