Pip5k1b
entrez
309419
canonical
uniprot
Q5CZZ9
canonical
ensembl
ENSRNOG00000015232
resolver
ensembl
ENSRNOG00055031591
resolver
ensembl
ENSRNOG00060022335
resolver
ensembl
ENSRNOG00065025300
resolver
ensp
ENSRNOP00000063506
resolver
ensp
ENSRNOP00000109124
resolver
ensp
ENSRNOP00055045268
resolver
ensp
ENSRNOP00060032387
resolver
ensp
ENSRNOP00065035964
resolver
enst
ENSRNOT00000068645
resolver
enst
ENSRNOT00000164404
resolver
enst
ENSRNOT00055054771
resolver
enst
ENSRNOT00060039171
resolver
enst
ENSRNOT00065043851
resolver
genesymbol
Pip5k1b
resolver
uniprot
A0ABK0LEK8
resolver
uniprot_entry
A0ABK0LEK8_RAT
resolver
uniprot_entry
PI51B_RAT
resolver
amino_acid_sequence
MSSTAENGDAVPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFLTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRAMRMHLTYDLKGSTYKRRASRKEREKPNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHILDHSLKDKEEEPLQNAPDAKRPGMQKVLYSTAMESIQGPGKSADGIIAENPDTMGGIPAKSHKGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKATSQEILSSISQEWKDEKQDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTISSSSLYVGEHYPHDRTTLYSNSKGLPSSSTFTLEEGTIYLTAEPNALETQDDASVLDVYL
uniprot
proteins
ec_number
2.7.1.68
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G protein-coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). {ECO:0000250|UniProtKB:P70181, ECO:0000250|UniProtKB:Q99755}.
uniprot
proteins
mass_dalton
60733
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
539
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P70181}. Cell membrane {ECO:0000250|UniProtKB:P70181}. Endomembrane system. Note=Associated with membranes. {ECO:0000250}.
uniprot
proteins