CCR3
entrez
1232
canonical
uniprot
P51677
canonical
ensembl
ENSG00000183625
resolver
ensp
ENSP00000350003
resolver
ensp
ENSP00000379271
resolver
ensp
ENSP00000389336
resolver
ensp
ENSP00000401822
resolver
ensp
ENSP00000441600
resolver
enst
ENST00000452454
resolver
enst
ENST00000457243
resolver
genesymbol
CCR3
resolver
genesymbol_syn
CMKBR3
resolver
hgnc
HGNC:1604
resolver
uniprot
B3KVQ1
resolver
uniprot
F5GWL6
resolver
uniprot
F6S373
resolver
uniprot
F6YDF7
resolver
uniprot
Q15748
resolver
uniprot
Q2YDB9
resolver
uniprot
Q86WD2
resolver
uniprot
Q8TDP4
resolver
uniprot
Q8TDP5
resolver
uniprot
Q8TDP6
resolver
uniprot
Q9ULY8
resolver
uniprot_entry
CCR3_HUMAN
resolver
uniprot_entry
F6S373_HUMAN
resolver
uniprot_entry
F6YDF7_HUMAN
resolver
uniprot_entry
Q8TDP4_HUMAN
resolver
uniprot_entry
Q8TDP5_HUMAN
resolver
uniprot_sec
B3KVQ1
resolver
uniprot_sec
F5GWL6
resolver
uniprot_sec
Q15748
resolver
uniprot_sec
Q2YDB9
resolver
uniprot_sec
Q86WD2
resolver
uniprot_sec
Q8TDP6
resolver
uniprot_sec
Q9ULY8
resolver
amino_acid_sequence
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
uniprot
proteins
function
FUNCTION: G protein-coupled receptor (GPCR) that plays a key role in the immune system by regulating the migration and activation of white blood cells in response to chemokines (PubMed:28994588). Selectively interacts with eosinophil-attracting chemokines such as eotaxin/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26 (PubMed:7622448, PubMed:8642344, PubMed:8676064). Ligand binding triggers intracellular signaling that leads to chemotaxis of immune cells. Mechanistically, signals through GNA14 or GNA16 to induce stimulation of phospholipase Cbeta/PLCB2 and subsequently chemotaxis (PubMed:18406577). Alternatively, transduces signal via GNAI1 resulting in elevated intracellular calcium levels and activation of the PI3K/AKT pathway (PubMed:8676064, PubMed:35570218). May also act as a possible functional receptor for NARS1 (PubMed:30171954). {ECO:0000269|PubMed:18406577, ECO:0000269|PubMed:28994588, ECO:0000269|PubMed:30171954, ECO:0000269|PubMed:7622448, ECO:0000269|PubMed:8642344, ECO:0000269|PubMed:8676064}.; FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. {ECO:0000269|PubMed:9789057}.
uniprot
proteins
mass_dalton
41044
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11196669
uniprot
proteins
pubmed
12079287
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
18406577
uniprot
proteins
pubmed
21077277
uniprot
proteins
pubmed
28994588
uniprot
proteins
pubmed
30171954
uniprot
proteins
pubmed
34917892
uniprot
proteins
pubmed
35570218
uniprot
proteins
pubmed
39482538
uniprot
proteins
pubmed
7622448
uniprot
proteins
pubmed
8642344
uniprot
proteins
pubmed
8676064
uniprot
proteins
pubmed
9323208
uniprot
proteins
pubmed
9789057
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28994588}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..62; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 73..93; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 108..129; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 147..171; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 204..223; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 240..264; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 282..305; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins