Rab11fip2
entrez
74998
canonical
uniprot
G3XA57
canonical
ensembl
ENSMUSG00000040022
resolver
ensp
ENSMUSP00000059978
resolver
ensp
ENSMUSP00000128813
resolver
enst
ENSMUST00000171986
resolver
genesymbol
Rab11fip2
resolver
uniprot
B9EID4
resolver
uniprot
G3UW57
resolver
uniprot
Q5HZI0
resolver
uniprot_entry
G3UW57_MOUSE
resolver
uniprot_entry
RFIP2_MOUSE
resolver
uniprot_sec
B9EID4
resolver
uniprot_sec
Q5HZI0
resolver
amino_acid_sequence
MMLSEQAQKWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLMQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIKNRGEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKGRKSDGVFSDTSSAIVPSTHMPDANPEFSSGEMQMKSKPKKPFLLGPQRLSSAHSMSDLTGSHLSSEKLKSSTVGPTHLLSRQIDSFGVVPESGSLKSPHRRTLSFDTSKLNQPGSIVDEGEHSFGRQSDPFTNVTASLPQKFATLPRKKNPFEESSEPWDSSMNLFSKPIEVRKESKREKREKVSLFERVTGKRDSRRPDKLNNGGSDSPCDLKSPSAFSENRQDYFEYESTNPFTAKFRASTIMPSSSFHVNPTSSEDLRKIPDNNPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDYIDNLLVRVMEETPSILRVPYEPSRKAGKFTNS
uniprot
proteins
function
FUNCTION: A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. {ECO:0000250|UniProtKB:Q7L804, ECO:0000269|PubMed:19335615}.
uniprot
proteins
mass_dalton
58207
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19335615
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Recycling endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. {ECO:0000250}.
uniprot
proteins