SRI
entrez
6717
canonical
uniprot
P30626
canonical
ensembl
ENSG00000075142
resolver
ensp
ENSP00000265729
resolver
ensp
ENSP00000378137
resolver
ensp
ENSP00000391148
resolver
ensp
ENSP00000397609
resolver
ensp
ENSP00000672522
resolver
enst
ENST00000419179
resolver
genesymbol
SRI
resolver
hgnc
HGNC:11292
resolver
uniprot
A8MTH6
resolver
uniprot
B4DHQ6
resolver
uniprot
B4DKK2
resolver
uniprot
D6W5Q0
resolver
uniprot
F6VXP0
resolver
uniprot_entry
B4DHQ6_HUMAN
resolver
uniprot_entry
F6VXP0_HUMAN
resolver
uniprot_entry
SORCN_HUMAN
resolver
uniprot_sec
A8MTH6
resolver
uniprot_sec
B4DKK2
resolver
uniprot_sec
D6W5Q0
resolver
amino_acid_sequence
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV
uniprot
proteins
function
FUNCTION: Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. {ECO:0000269|PubMed:17699613}.
uniprot
proteins
mass_dalton
21676
uniprot
proteins
mutagenesis
MUTAGEN 112; /note="F->L: Reduces affinity for calcium 5-fold.
uniprot
proteins
pubmed
11714909
uniprot
proteins
pubmed
12804766
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16341674
uniprot
proteins
pubmed
17699613
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7873602
uniprot
proteins
pubmed
8561500
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.
uniprot
proteins