Dctn2
entrez
69654
canonical
uniprot
Q99KJ8
canonical
ensembl
ENSMUSG00000025410
resolver
ensp
ENSMUSP00000026479
resolver
ensp
ENSMUSP00000252532
resolver
enst
ENSMUST00000026479
resolver
genesymbol
Dctn2
resolver
uniprot
Q3TPZ5
resolver
uniprot_entry
DCTN2_MOUSE
resolver
uniprot_entry
Q3TPZ5_MOUSE
resolver
amino_acid_sequence
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELSSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGDYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLADPDGALAKRLLLQLEATKSSKGSSGGKATAGAPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGACLMETVELLQAKVSALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQNKVHQLYETIQRWSPVASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMMASSLKDNTALLTQVQTTMRENLATVEGNFASIDARMKRLGK
uniprot
proteins
function
FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (PubMed:14983524). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000269|PubMed:14983524}.
uniprot
proteins
mass_dalton
44117
uniprot
proteins
protein_family
Dynactin subunit 2 family
uniprot
proteins
pubmed
11483508
uniprot
proteins
pubmed
14983524
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22956769
uniprot
proteins
pubmed
9144527
uniprot
proteins
sequence_length
402
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14983524, ECO:0000269|PubMed:9144527}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
uniprot
proteins