CEMIP2
entrez
23670
canonical
uniprot
Q9UHN6
canonical
ensembl
ENSG00000135048
resolver
ensp
ENSP00000366243
resolver
ensp
ENSP00000366266
resolver
ensp
ENSP00000523395
resolver
ensp
ENSP00000581482
resolver
genesymbol
CEMIP2
resolver
genesymbol_syn
KIAA1412
resolver
genesymbol_syn
TMEM2
resolver
hgnc
HGNC:11869
resolver
uniprot
A6H8W9
resolver
uniprot
B2RTQ6
resolver
uniprot
Q5T838
resolver
uniprot
Q5T839
resolver
uniprot
Q5T840
resolver
uniprot
Q5T841
resolver
uniprot
Q8NBP6
resolver
uniprot
Q9P2D5
resolver
uniprot_entry
CEIP2_HUMAN
resolver
uniprot_sec
A6H8W9
resolver
uniprot_sec
B2RTQ6
resolver
uniprot_sec
Q5T838
resolver
uniprot_sec
Q5T839
resolver
uniprot_sec
Q5T840
resolver
uniprot_sec
Q5T841
resolver
uniprot_sec
Q8NBP6
resolver
uniprot_sec
Q9P2D5
resolver
amino_acid_sequence
MYATDSRGHSPAFLQPQNGNSRHPSGYVPGKVVPLRPPPPPKSQASAKFTSIRREDRATFAFSPEEQQAQRESQKQKRHKNTFICFAITSFSFFIALAIILGISSKYAPDENCPDQNPRLRNWDPGQDSAKQVVIKEGDMLRLTSDATVHSIVIQDGGLLVFGDNKDGSRNITLRTHYILIQDGGALHIGAEKCRYKSKATITLYGKSDEGESMPTFGKKFIGVEAGGTLELHGARKASWTLLARTLNSSGLPFGSYTFEKDFSRGLNVRVIDQDTAKILESERFDTHEYRNESRRLQEFLRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQERLGSELIQGLGYRQAWALVGVIDGGSTSCNESVRNYENHSSGGKALAQREFYTVDGQKFSVTAYSEWIEGVSLSGFRVEVVDGVKLNLLDDVSSWKPGDQIVVASTDYSMYQAEEFTLLPCSECSHFQVKVKETPQFLHMGEIIDGVDMRAEVGILTRNIVIQGEVEDSCYAENQCQFFDYDTFGGHIMIMKNFTSVHLSYVELKHMGQQQMGRYPVHFHLCGDVDYKGGYRHATFVDGLSIHHSFSRCITVHGTNGLLIKDTIGFDTLGHCFFLEDGIEQRNTLFHNLGLLTKPGTLLPTDRNNSMCTTMRDKVFGNYIPVPATDCMAVSTFWIAHPNNNLINNAAAGSQDAGIWYLFHKEPTGESSGLQLLAKPELTPLGIFYNNRVHSNFKAGLFIDKGVKTTNSSAADPREYLCLDNSARFRPHQDANPEKPRVAALIDRLIAFKNNDNGAWVRGGDIIVQNSAFADNGIGLTFASDGSFPSDEGSSQEVSESLFVGESRNYGFQGGQNKYVGTGGIDQKPRTLPRNRTFPIRGFQIYDGPIHLTRSTFKKYVPTPDRYSSAIGFLMKNSWQITPRNNISLVKFGPHVSLNVFFGKPGPWFEDCEMDGDKNSIFHDIDGSVTGYKDAYVGRMDNYLIRHPSCVNVSKWNAVICSGTYAQVYVQTWSTQNLSMTITRDEYPSNPMVLRGINQKAAFPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKNDWIRVGLCYPSNTSFQVTFGYLQRQNGSLSKIEEYEPVHSLEELQRKQSERKFYFDSSTGLLFLYLKAKSHRHGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPQYYRKPSVVKRMPAMLTGLCQGCGTRQVVFTSDPHKSYLPVQFQSPDKAETQRGDPSVISVNGTDFTFRSAGVLLLVVDPCSVPFRLTEKTVFPLADVSRIEEYLKTGIPPRSIVLLSTRGEIKQLNISHLLVPLGLAKPAHLYDKGSTIFLGFSGNFKPSWTKLFTSPAGQGLGVLEQFIPLQLDEYGCPRATTVRRRDLELLKQASKAH
uniprot
proteins
ec_number
3.2.1.35
uniprot
proteins
function
FUNCTION: Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 10-5 kDa fragments (PubMed:37527776). Very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate. Has an essential function in systemic hyaluronan catabolism and turnover and regulates cell adhesion and migration via hyaluronan degradation at focal adhesion sites (By similarity). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). {ECO:0000250|UniProtKB:A3KPQ7, ECO:0000250|UniProtKB:Q5FWI3, ECO:0000269|PubMed:37527776}.
uniprot
proteins
mass_dalton
154374
uniprot
proteins
protein_family
CEMIP family
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
10767548
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
37196767
uniprot
proteins
pubmed
37527776
uniprot
proteins
sequence_length
1383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5FWI3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q5FWI3}.
uniprot
proteins
transmembrane_region
TRANSMEM 83..103; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins