IRF5
entrez
3663
canonical
uniprot
Q13568
canonical
ensembl
ENSG00000128604
resolver
ensp
ENSP00000349770
resolver
ensp
ENSP00000385352
resolver
ensp
ENSP00000418037
resolver
ensp
ENSP00000419149
resolver
ensp
ENSP00000419950
resolver
ensp
ENSP00000568799
resolver
ensp
ENSP00000568801
resolver
ensp
ENSP00000568803
resolver
ensp
ENSP00000568805
resolver
ensp
ENSP00000568806
resolver
ensp
ENSP00000626653
resolver
genesymbol
IRF5
resolver
hgnc
HGNC:6120
resolver
uniprot
A0A0G2USB5
resolver
uniprot
A4D1J8
resolver
uniprot
A8DUA8
resolver
uniprot
A8DUA9
resolver
uniprot
B7Z1M2
resolver
uniprot
E7EQ16
resolver
uniprot
E7EW54
resolver
uniprot
Q1A7B4
resolver
uniprot
Q64GA9
resolver
uniprot
Q64GB1
resolver
uniprot
Q64GB2
resolver
uniprot
Q6RCM8
resolver
uniprot
Q9BQF0
resolver
uniprot_entry
A0A0G2USB5_HUMAN
resolver
uniprot_entry
B7Z1M2_HUMAN
resolver
uniprot_entry
IRF5_HUMAN
resolver
uniprot_sec
A4D1J8
resolver
uniprot_sec
A8DUA8
resolver
uniprot_sec
A8DUA9
resolver
uniprot_sec
E7EQ16
resolver
uniprot_sec
E7EW54
resolver
uniprot_sec
Q1A7B4
resolver
uniprot_sec
Q64GA9
resolver
uniprot_sec
Q64GB1
resolver
uniprot_sec
Q64GB2
resolver
uniprot_sec
Q6RCM8
resolver
uniprot_sec
Q9BQF0
resolver
activity_regulation
ACTIVITY REGULATION: Maintained as a monomer in an autoinhibited state (PubMed:18836453, PubMed:22412986, PubMed:25326418). Phosphorylation and activation follow the following steps: innate adapter protein TASL recruits IRF5, thereby licensing IRF5 for phosphorylation by IKBKB (PubMed:32433612). Phosphorylated IRF5 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce IFNs (PubMed:25326418, PubMed:32433612). {ECO:0000269|PubMed:18836453, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:32433612}.; ACTIVITY REGULATION: (Microbial infection) Activated upon coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33440148}.
uniprot
proteins
amino_acid_sequence
MNQSIPVAPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSFGAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPGPLPASLPPAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPMHPAGMQ
uniprot
proteins
disease_involvement
DISEASE: Inflammatory bowel disease 14 (IBD14) [MIM:612245]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269|PubMed:17881657}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Systemic lupus erythematosus 10 (SLEB10) [MIM:612251]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269|PubMed:15657875}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269|PubMed:17599733}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612, PubMed:40639948). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000250|UniProtKB:P56477, ECO:0000269|PubMed:11303025, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:40639948}.
uniprot
proteins
mass_dalton
56044
uniprot
proteins
mutagenesis
MUTAGEN 265; /note="T->A: Significant reduction of phosphorylation and transcriptional activation."; /evidence="ECO:0000269|PubMed:40639948"; MUTAGEN 446; /note="S->A: Abolished nuclear translocation."; /evidence="ECO:0000269|PubMed:25326418
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of serine and threonine residues by IKBKB in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/EP300 and initiation of transcription. Phosphorylation at Thr-265 by STK25 induces IRF5 transcriptional activation (PubMed:40639948). {ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:18836453, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:40639948}.; PTM: 'Lys-63'-linked polyubiquitination by TRAF6 is required for activation. {ECO:0000269|PubMed:18824541}.
uniprot
proteins
protein_family
IRF family
uniprot
proteins
pubmed
11303025
uniprot
proteins
pubmed
12138184
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15556946
uniprot
proteins
pubmed
15657875
uniprot
proteins
pubmed
15695821
uniprot
proteins
pubmed
15805103
uniprot
proteins
pubmed
16642019
uniprot
proteins
pubmed
17599733
uniprot
proteins
pubmed
17881657
uniprot
proteins
pubmed
18824541
uniprot
proteins
pubmed
18836453
uniprot
proteins
pubmed
22412986
uniprot
proteins
pubmed
25326418
uniprot
proteins
pubmed
32433612
uniprot
proteins
pubmed
33440148
uniprot
proteins
pubmed
40639948
uniprot
proteins
sequence_length
498
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12138184, ECO:0000269|PubMed:15556946, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418}. Nucleus {ECO:0000269|PubMed:12138184, ECO:0000269|PubMed:15556946, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418}. Note=Shuttles between the nucleus and the cytoplasm: upon activation by the TLR adapter MYD88 and subsequent phosphorylation, translocates to the nucleus. {ECO:0000269|PubMed:12138184, ECO:0000269|PubMed:15556946, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418}.
uniprot
proteins