ICOSLG
entrez
23308
canonical
uniprot
O75144
canonical
ensembl
ENSG00000160223
resolver
ensp
ENSP00000339477
resolver
ensp
ENSP00000383228
resolver
ensp
ENSP00000384432
resolver
ensp
ENSP00000494882
resolver
ensp
ENSP00000514957
resolver
ensp
ENSP00000514960
resolver
enst
ENST00000643466
resolver
enst
ENST00000700355
resolver
enst
ENST00000700358
resolver
genesymbol
ICOSLG
resolver
genesymbol_syn
B7H2
resolver
genesymbol_syn
B7RP1
resolver
genesymbol_syn
ICOSL
resolver
genesymbol_syn
KIAA0653
resolver
hgnc
HGNC:17087
resolver
uniprot
A0A2R8Y5W7
resolver
uniprot
A0A8V8TPM3
resolver
uniprot
A0A8V8TQV9
resolver
uniprot
A0N0L8
resolver
uniprot
A8MUZ1
resolver
uniprot
B7Z1W8
resolver
uniprot
Q9HD18
resolver
uniprot
Q9NRQ1
resolver
uniprot_entry
A0A2R8Y5W7_HUMAN
resolver
uniprot_entry
A0A8V8TPM3_HUMAN
resolver
uniprot_entry
A0A8V8TQV9_HUMAN
resolver
uniprot_entry
A0N0L8_HUMAN
resolver
uniprot_entry
B7Z1W8_HUMAN
resolver
uniprot_entry
ICOSL_HUMAN
resolver
uniprot_sec
A8MUZ1
resolver
uniprot_sec
Q9HD18
resolver
uniprot_sec
Q9NRQ1
resolver
amino_acid_sequence
MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTGHV
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 119 (IMD119) [MIM:620825]: An autosomal recessive immunologic disorder characterized by childhood-onset of recurrent respiratory tract infections, susceptibility to chronic DNA-based viral infections, hypogammaglobulinemia, and panlymphopenia. {ECO:0000269|PubMed:30498080}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion (PubMed:11007762, PubMed:11023515, PubMed:30498080). Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP) (PubMed:30498080). {ECO:0000250, ECO:0000269|PubMed:11007762, ECO:0000269|PubMed:11023515, ECO:0000269|PubMed:30498080}.
uniprot
proteins
mass_dalton
33349
uniprot
proteins
protein_family
BTN/MOG family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
10657606
uniprot
proteins
pubmed
10779774
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
11007762
uniprot
proteins
pubmed
11023515
uniprot
proteins
pubmed
11390480
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
28484017
uniprot
proteins
pubmed
30498080
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
302
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11007762, ECO:0000269|PubMed:30498080}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11390480}.
uniprot
proteins
transmembrane_region
TRANSMEM 257..277; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins