IL13
entrez
3596
canonical
uniprot
P35225
canonical
ensembl
ENSG00000169194
resolver
ensp
ENSP00000304915
resolver
enst
ENST00000304506
resolver
genesymbol
IL13
resolver
genesymbol_syn
NC30
resolver
hgnc
HGNC:5973
resolver
uniprot
O43644
resolver
uniprot
Q4VB52
resolver
uniprot
Q4VB53
resolver
uniprot
Q9UDC7
resolver
uniprot_entry
IL13_HUMAN
resolver
uniprot_entry
Q4VB53_HUMAN
resolver
uniprot_sec
O43644
resolver
uniprot_sec
Q4VB52
resolver
uniprot_sec
Q9UDC7
resolver
amino_acid_sequence
MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGQFN
uniprot
proteins
disease_involvement
DISEASE: Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. {ECO:0000269|PubMed:10699178, ECO:0000269|PubMed:11588017, ECO:0000269|PubMed:12928861}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:8096327, PubMed:8097324). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (PubMed:7903680, PubMed:8759755). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and down-regulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Also functions on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils (PubMed:8639787). Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 (PubMed:9013879). Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (PubMed:21622864). Induces inflammatory response in esophageal epithelium which results in a dysregulation of desmosome intercellular adhesion junctions, via down-regulation of DSG1 (PubMed:24220297). {ECO:0000250|UniProtKB:P20109, ECO:0000250|UniProtKB:P42203, ECO:0000269|PubMed:21622864, ECO:0000269|PubMed:24220297, ECO:0000269|PubMed:7903680, ECO:0000269|PubMed:8096327, ECO:0000269|PubMed:8097324, ECO:0000269|PubMed:8639787, ECO:0000269|PubMed:8759755, ECO:0000269|PubMed:9013879}.
uniprot
proteins
mass_dalton
15788
uniprot
proteins
protein_family
IL-4/IL-13 family
uniprot
proteins
pubmed
10699178
uniprot
proteins
pubmed
11419948
uniprot
proteins
pubmed
11588017
uniprot
proteins
pubmed
12928861
uniprot
proteins
pubmed
1408833
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20223216
uniprot
proteins
pubmed
21622864
uniprot
proteins
pubmed
24220297
uniprot
proteins
pubmed
7721105
uniprot
proteins
pubmed
7903680
uniprot
proteins
pubmed
8096327
uniprot
proteins
pubmed
8097324
uniprot
proteins
pubmed
8605348
uniprot
proteins
pubmed
8639787
uniprot
proteins
pubmed
8759755
uniprot
proteins
pubmed
9013879
uniprot
proteins
sequence_length
146
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins