KSR1
entrez
8844
canonical
uniprot
Q8IVT5
canonical
ensembl
ENSG00000141068
resolver
ensp
ENSP00000381952
resolver
ensp
ENSP00000381958
resolver
ensp
ENSP00000494039
resolver
ensp
ENSP00000494552
resolver
enst
ENST00000644974
resolver
genesymbol
KSR1
resolver
genesymbol_syn
KSR
resolver
hgnc
HGNC:6465
resolver
uniprot
A0A2R8Y5H9
resolver
uniprot
F8WEA9
resolver
uniprot
H7BYU0
resolver
uniprot
Q13476
resolver
uniprot_entry
A0A2R8Y5H9_HUMAN
resolver
uniprot_entry
KSR1_HUMAN
resolver
uniprot_sec
F8WEA9
resolver
uniprot_sec
H7BYU0
resolver
uniprot_sec
Q13476
resolver
amino_acid_sequence
MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRFSDWLYTFNVRPEVVQEIPRDLTLDALLEMNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGEHKEDSSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPTPSFSEGLSDTCIPLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAFNISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}.
uniprot
proteins
mass_dalton
102160
uniprot
proteins
mutagenesis
MUTAGEN 47; /note="L->D: Reduces interaction with BRAF and MAP2K1 and thus phosphorylation of MAP2K1."; /evidence="ECO:0000269|PubMed:29433126"; MUTAGEN 62; /note="C->D: Reduces interaction with BRAF and MAP2K1 and thus phosphorylation of MAP2K1."; /evidence="ECO:0000269|PubMed:29433126"; MUTAGEN 72; /note="E->K: Loss of interaction with BRAF and MAP2K1 and severe decrease in MAP2K1 phosphorylation levels."; /evidence="ECO:0000269|PubMed:29433126"; MUTAGEN 602..604; /note="YLQ->DDE: No effect on MAP2K1- or MAP2K2-mediated-BRAF-KSR1 dimerization and BRAF activation."; /evidence="ECO:0000269|PubMed:29433126"; MUTAGEN 637; /note="A->F: No effect on MAP2K1 or MAP2K2 mediated-BRAF-KSR1 dimerization and BRAF activation."; /evidence="ECO:0000269|PubMed:29433126"; MUTAGEN 639; /note="R->M: No effect on MAP2K1 mediated-BRAF-KSR1 dimerization and BRAF activation."; /evidence="ECO:0000269|PubMed:29433126"; MUTAGEN 665; /note="R->H: Loss of MAP2K1 mediated-BRAF-KSR1 dimerization."; /evidence="ECO:0000269|PubMed:29433126"; MUTAGEN 831; /note="W->R: Loss of the interaction with MAP2K1 resulting in loss of BRAF-KSR1 dimerization and BRAF activation. No effect on ATP binding or interaction with HSP90AA1, 14-3-3 and CDC37."; /evidence="ECO:0000269|PubMed:29433126
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-311 and, to a higher extent, on Ser-406 by MARK3. Dephosphorylated on Ser-406 by PPP2CA. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane-associated. Phosphorylated by PKA at Ser-888. Phosphorylation at Ser-888 is required for cAMP-dependent activation of MAPK1 and/or MAPK3 (By similarity). {ECO:0000250|UniProtKB:Q61097}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
10409742
uniprot
proteins
pubmed
12007434
uniprot
proteins
pubmed
12941695
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20679487
uniprot
proteins
pubmed
21102438
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29433126
uniprot
proteins
pubmed
8521512
uniprot
proteins
sequence_length
923
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20679487}. Membrane {ECO:0000269|PubMed:20679487}; Peripheral membrane protein {ECO:0000269|PubMed:20679487}. Cell membrane {ECO:0000250|UniProtKB:Q61097}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q61097}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q61097}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20679487}. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery. {ECO:0000305|PubMed:12007434}.
uniprot
proteins