PLCG1
entrez
5335
canonical
uniprot
P19174
canonical
ensembl
ENSG00000124181
resolver
ensp
ENSP00000362368
resolver
ensp
ENSP00000508698
resolver
genesymbol
PLCG1
resolver
genesymbol_syn
PLC1
resolver
hgnc
HGNC:9065
resolver
uniprot
B7ZLY7
resolver
uniprot
B9EGH4
resolver
uniprot
E1P5W4
resolver
uniprot
Q2V575
resolver
uniprot_entry
PLCG1_HUMAN
resolver
uniprot_sec
B7ZLY7
resolver
uniprot_sec
B9EGH4
resolver
uniprot_sec
E1P5W4
resolver
uniprot_sec
Q2V575
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on tyrosine residues. {ECO:0000269|PubMed:1370476}.
uniprot
proteins
amino_acid_sequence
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRISQEHLADHFDSRERRAPRRTRVNGDNRL
uniprot
proteins
disease_involvement
DISEASE: Immune dysregulation, autoimmunity, and autoinflammation (IDAA) [MIM:620514]: An autosomal dominant disorder characterized by anemia and thrombocytopenia associated with circulating autoantibodies, positive Coombs test, immune dysregulation, and increased levels of proinflammatory cytokines. {ECO:0000269|PubMed:37422272}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.4.11
uniprot
proteins
function
FUNCTION: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}.
uniprot
proteins
mass_dalton
148532
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated in response to signaling via activated FLT3, KIT and PDGFRA (By similarity). Tyrosine phosphorylated by activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylated by activated FLT1 and KDR. Tyrosine phosphorylated by activated PDGFRB. The receptor-mediated activation of PLCG1 involves its phosphorylation by tyrosine kinases, in response to ligation of a variety of growth factor receptors and immune system receptors. For instance, SYK phosphorylates and activates PLCG1 in response to ligation of the B-cell receptor. May be dephosphorylated by PTPRJ. Phosphorylated by ITK and TXK on Tyr-783 upon TCR activation in T-cells. {ECO:0000250, ECO:0000269|PubMed:10102632, ECO:0000269|PubMed:11564877, ECO:0000269|PubMed:1370476, ECO:0000269|PubMed:15215251, ECO:0000269|PubMed:16081816, ECO:0000269|PubMed:16844695, ECO:0000269|PubMed:17561467, ECO:0000269|PubMed:20494825, ECO:0000269|PubMed:2167438, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8657103}.; PTM: Ubiquitinated by CBLB in activated T-cells. {ECO:0000250|UniProtKB:Q62077}.
uniprot
proteins
pubmed
10102632
uniprot
proteins
pubmed
10488157
uniprot
proteins
pubmed
10747847
uniprot
proteins
pubmed
10873601
uniprot
proteins
pubmed
11259588
uniprot
proteins
pubmed
11518702
uniprot
proteins
pubmed
11564877
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12913111
uniprot
proteins
pubmed
1370476
uniprot
proteins
pubmed
15102829
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15215251
uniprot
proteins
pubmed
15270728
uniprot
proteins
pubmed
15488758
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15526160
uniprot
proteins
pubmed
15863030
uniprot
proteins
pubmed
16081816
uniprot
proteins
pubmed
1656221
uniprot
proteins
pubmed
16844695
uniprot
proteins
pubmed
17229814
uniprot
proteins
pubmed
17561467
uniprot
proteins
pubmed
17620338
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19286672
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20494825
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
2167438
uniprot
proteins
pubmed
21765395
uniprot
proteins
pubmed
22561606
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
37422272
uniprot
proteins
pubmed
7518429
uniprot
proteins
pubmed
7681365
uniprot
proteins
pubmed
8657103
uniprot
proteins
pubmed
9038210
uniprot
proteins
pubmed
9178760
uniprot
proteins
pubmed
9489702
uniprot
proteins
sequence_length
1290
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, lamellipodium {ECO:0000269|PubMed:17229814}. Cell projection, ruffle {ECO:0000269|PubMed:17229814}. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. {ECO:0000269|PubMed:17229814}.
uniprot
proteins