Sgo2a
entrez
68549
canonical
uniprot
Q7TSY8
canonical
ensembl
ENSMUSG00000026039
resolver
ensp
ENSMUSP00000027202
resolver
enst
ENSMUST00000027202
resolver
genesymbol
Sgo2a
resolver
genesymbol_syn
Sgo2
resolver
genesymbol_syn
Sgol2
resolver
genesymbol_syn
Sgol2a
resolver
uniprot
Q811I4
resolver
uniprot
Q8C9C4
resolver
uniprot
Q8CGJ4
resolver
uniprot
Q9CS55
resolver
uniprot_entry
SGO2A_MOUSE
resolver
uniprot_sec
Q811I4
resolver
uniprot_sec
Q8C9C4
resolver
uniprot_sec
Q8CGJ4
resolver
uniprot_sec
Q9CS55
resolver
amino_acid_sequence
MEYPGIKVDTVTSGIQRRVKGRIAKTNLNVSLASKIKAKILNNSSIFKISLKHNNRALARALSKEKENSRRITTEKMQLQKEVEKLNFENTFLRLKLNTLNKKLVEIESHVSNDLLTAIEISSLSEFHQGSFLLSATKKQRNSKQCKPAHLPYARVLLTSENDDDDGADDKWQTKCNNRTISKTSPDSTSSVSRQPSSLHQCNLKAFPPKEDNQKTCGSGHLEHTSSVDILPNESHSDQSPKSSLSEMKTAPSPSLRREKLSHGNVTMRKKCVSSTPDILYVTDLDHQPTSSPGSNWNNEIHGHTNETSNNTQRNAECFLDLPSESSSEPDAKRMELVQKNTDSFHFQKTVYDAADMELTATDIGKIVAVSKSKKNQNKKKADCRKETFRKVKGASSDKKRESSKRECKDGSEVGAEEEADAARAERGAGVLDGRGDSEEPNCISSTEQPSQVNTQKKRTLQNSSDQENIQNTKRRQTYTTDEQEETNPFSRHSVKFLQDGKFDLCQKTLHHNLSKPSRQTFVIRKSEKDNLFPNQEDKDTISENLEVTNEFHIDDLSIEANENVCDHETQTMLDLKKSVSAQQNQTKINKTKQKINRRTKIISVMSQVYEDNDKDIHVLEKDNFPFHTQANKETTSGNLESSKEFESPLLFTRDNGSLRDCKTQNVLDLHKQIPDLYPDRNESQISKIPRQKVNRKTEVISGVKCFSNDQGVHCSEKDKSLLLQKDKDFPGTLKDLSEFDTPAFCNKDSAKSCDYKSEMLLGLKKHDPNMQPACQDDSKAGKKLRQKVNRKTEIISKITQIHENDRGSTHDSLNKKLCQKVNISKIISQMNQIYETINEDGNGFKSSIKDCEDIKSCDFGEINSNKKENYDPIQDPCTLVKKTKRKGSCKAGSSLAGAKNRCGLQLTDSSQVQSVPLDSGLRHHPNEADSGPGEQTNLPKMQKQSAGRSLGDAFSVSLGKEGSRPAKAVSKMTPKSKKRKLPLGCSPETHGTVEITPNTDLAKAVDSQQTEKENYLEKEKIAKRKPDFCTKVLKPLSETCSSNIKNSSLDSMCKSSLPLSISSRKTLMLEESSSLESTCIFQVGDAAHEKITTGTRNPHHRTQKSTPGSRTSLVLVDTSSVSDTNPANPENESEGQSSHPMRRKRQCVPLNLTEPSLRSKMRR
uniprot
proteins
function
FUNCTION: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250|UniProtKB:Q562F6, ECO:0000269|PubMed:18084284, ECO:0000269|PubMed:18765791}.
uniprot
proteins
mass_dalton
130277
uniprot
proteins
protein_family
Shugoshin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17205076
uniprot
proteins
pubmed
18084284
uniprot
proteins
pubmed
18765791
uniprot
proteins
sequence_length
1164
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q562F6}. Chromosome, centromere {ECO:0000269|PubMed:17205076, ECO:0000269|PubMed:18084284}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17205076}. Note=Centromeric localization requires the presence of BUB1 and AUKRB (By similarity). During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres (PubMed:17205076, PubMed:18084284). SGO2A and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost (PubMed:17205076). During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (PubMed:17205076). {ECO:0000250|UniProtKB:Q562F6, ECO:0000269|PubMed:17205076, ECO:0000269|PubMed:18084284}.
uniprot
proteins