KLRK1
entrez
22914
canonical
uniprot
P26718
canonical
ensembl
ENSG00000213809
resolver
ensp
ENSP00000240618
resolver
ensp
ENSP00000446003
resolver
enst
ENST00000240618
resolver
enst
ENST00000540818
resolver
genesymbol
KLRK1
resolver
genesymbol_syn
D12S2489E
resolver
genesymbol_syn
NKG2D
resolver
hgnc
HGNC:18788
resolver
uniprot
A8K7K5
resolver
uniprot
A8K7P4
resolver
uniprot
Q9NR41
resolver
uniprot_entry
NKG2D_HUMAN
resolver
uniprot_sec
A8K7K5
resolver
uniprot_sec
A8K7P4
resolver
uniprot_sec
Q9NR41
resolver
amino_acid_sequence
MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKSKCRENASPFFFCCFIAVAMGIRFIIMVTIWSAVFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV
uniprot
proteins
function
FUNCTION: Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11224526, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:19658097, ECO:0000269|PubMed:21898152, ECO:0000269|PubMed:23298206, ECO:0000269|PubMed:28559451}.
uniprot
proteins
mass_dalton
25304
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="R->A: Inhibits association with the HCST signaling dimer."; /evidence="ECO:0000269|PubMed:15894612
uniprot
proteins
pubmed
10426993
uniprot
proteins
pubmed
10426994
uniprot
proteins
pubmed
11015446
uniprot
proteins
pubmed
11224526
uniprot
proteins
pubmed
11751968
uniprot
proteins
pubmed
11754823
uniprot
proteins
pubmed
11777960
uniprot
proteins
pubmed
11973127
uniprot
proteins
pubmed
12679019
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15240696
uniprot
proteins
pubmed
15294961
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15894612
uniprot
proteins
pubmed
16444266
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
19658097
uniprot
proteins
pubmed
2007850
uniprot
proteins
pubmed
21898152
uniprot
proteins
pubmed
23298206
uniprot
proteins
pubmed
23696226
uniprot
proteins
pubmed
28559451
uniprot
proteins
pubmed
9683661
uniprot
proteins
sequence_length
216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}; Single-pass type II membrane protein {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}. Note=Colocalized with HCST on the cell surface.
uniprot
proteins
transmembrane_region
TRANSMEM 52..72; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins