Commd5
entrez
245974
canonical
uniprot
Q9ERR2
canonical
ensembl
ENSRNOG00000004484
resolver
ensp
ENSRNOP00000005925
resolver
ensp
ENSRNOP00000077291
resolver
ensp
ENSRNOP00000080446
resolver
ensp
ENSRNOP00000108620
resolver
enst
ENSRNOT00000005925
resolver
enst
ENSRNOT00000100252
resolver
enst
ENSRNOT00000109113
resolver
enst
ENSRNOT00000124013
resolver
genesymbol
Commd5
resolver
genesymbol_syn
LOC100910472
resolver
uniprot
A0A8I5ZPU4
resolver
uniprot
G3V6K0
resolver
uniprot_entry
COMD5_RAT
resolver
uniprot_entry
G3V6K0_RAT
resolver
uniprot_sec
A0A8I5ZPU4
resolver
amino_acid_sequence
MSALGAAAPYLHHPADSHSGRVSFLGSQPSPEVTAVAQLLKDLDRSTFRKLLKLVVGALHGKDCREAVEQLGASANLSEERLAVLLAGTHTLLQQALRLPPASLKPDAFQEELQELGIPQDLIGDLASLAFGSQRPLLDSVAQQQGSSLPHVSYFRWRVDVAISTSAQSRSLQPSVLMQLKLTDGSAHRFEVPIAKFQELRYSVALVLKEMAELEKKCERKLQD
uniprot
proteins
function
FUNCTION: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). Negatively regulates cell proliferation (PubMed:12620924). Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway (PubMed:12620924). Involved in kidney proximal tubule morphogenesis (PubMed:24515317). Down-regulates activation of NF-kappa-B (By similarity). {ECO:0000250|UniProtKB:Q9GZQ3}.
uniprot
proteins
mass_dalton
24453
uniprot
proteins
protein_family
COMM domain-containing protein 5 family
uniprot
proteins
pubmed
10918053
uniprot
proteins
pubmed
12620924
uniprot
proteins
pubmed
24515317
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10918053}.
uniprot
proteins