Sc5d
entrez
235293
canonical
uniprot
O88822
canonical
ensembl
ENSMUSG00000032018
resolver
ensp
ENSMUSP00000057354
resolver
ensp
ENSMUSP00000130438
resolver
enst
ENSMUST00000052725
resolver
enst
ENSMUST00000169609
resolver
genesymbol
Sc5d
resolver
genesymbol_syn
Sc5dl
resolver
uniprot
Q8BGI0
resolver
uniprot_entry
SC5D_MOUSE
resolver
uniprot_sec
Q8BGI0
resolver
amino_acid_sequence
MDLVLSAADYYFFTPYVYPATWPEDNIIRQTISLLIVTNLGAYILYFFCATLSYYFVYDHSLMKHPQFLKNQVSREIVFTVKSLPWISIPTVSLFLLELRGYSKLYDDIGDFPNGWIHLMVSVVSFLFFTDMLIYWIHRGLHHRLVYKRIHKPHHIWKIPTPFASHAFHPVDGFLQSLPYHIYPFVFPLHKVVYLGLYVLVNVWTISIHDGDFRVPQILRPFINGSAHHTDHHMFFDYNYGQYFTLWDRIGGSFKHPSSFEGKGPHSYVKNMTEKESNSFAENGCKGKKVGNGEFTKNK
uniprot
proteins
ec_number
1.14.19.20
uniprot
proteins
function
FUNCTION: Catalyzes the penultimate step of the biosynthesis of cholesterol, the dehydrogenation of lathosterol into 7-dehydrocholesterol (7-DHC). Cholesterol is the major sterol component in mammalian membranes and a precursor for bile acid and steroid hormone synthesis. In addition to its essential role in cholesterol biosynthesis, it also indirectly regulates ferroptosis through the production of 7-DHC. By diverting the spread of damage caused by peroxyl radicals from the phospholipid components to its sterol nucleus, 7-DHC prevents this form of cell death. {ECO:0000250|UniProtKB:O75845}.
uniprot
proteins
mass_dalton
35062
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; cholesterol biosynthesis. {ECO:0000250|UniProtKB:O75845}.
uniprot
proteins
protein_family
Sterol desaturase family
uniprot
proteins
pubmed
10786622
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9EQS5}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins