Gata4
entrez
54254
canonical
uniprot
P46152
canonical
ensembl
ENSRNOG00000010708
resolver
ensembl
ENSRNOG00055011843
resolver
ensembl
ENSRNOG00060019456
resolver
ensembl
ENSRNOG00065029081
resolver
ensp
ENSRNOP00000014320
resolver
ensp
ENSRNOP00055016215
resolver
ensp
ENSRNOP00060027589
resolver
ensp
ENSRNOP00065041280
resolver
enst
ENSRNOT00000014320
resolver
enst
ENSRNOT00055020129
resolver
enst
ENSRNOT00060033698
resolver
enst
ENSRNOT00065050257
resolver
genesymbol
Gata4
resolver
uniprot_entry
GATA4_RAT
resolver
amino_acid_sequence
MYQSLAMAANHGPPPGAYEAGGPGAFMHSAGAASSPVYVPTPRVPSSVLGLSYLQGGGSGAASGATSGGSSGAGPSGAGPGTQQGSPGWSQAGAEGAAYTPPPVSPRFSFPGTTGSLAAAAAAAAAREAAAYSSSGGAAGAGLAGREQYGRPGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPGRANPARHPNLDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAGPPGESLPPSSGASSNSSNATSSSSSSEEMRPIKTEPGLSSHYGHSSSMSQTFSTVSGHGSSIHPVLSALKLSPQGYPSPVTQTSQASSKQDSWNSLVLADSHGDIITA
uniprot
proteins
function
FUNCTION: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (PubMed:15329343). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (By similarity). {ECO:0000250|UniProtKB:P43694, ECO:0000250|UniProtKB:Q08369, ECO:0000269|PubMed:15329343}.
uniprot
proteins
mass_dalton
44597
uniprot
proteins
post_translational_modification
PTM: Methylation at Lys-299 attenuates transcriptional activity. {ECO:0000250}.
uniprot
proteins
pubmed
15329343
uniprot
proteins
pubmed
16166646
uniprot
proteins
pubmed
8183957
uniprot
proteins
pubmed
8248184
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P43694}.
uniprot
proteins