Il25
entrez
140806
canonical
uniprot
Q8VHH8
canonical
ensembl
ENSMUSG00000040770
resolver
ensp
ENSMUSP00000039641
resolver
enst
ENSMUST00000037863
resolver
genesymbol
Il25
resolver
genesymbol_syn
Il17e
resolver
uniprot_entry
IL25_MOUSE
resolver
amino_acid_sequence
MYQAVAFLAMIVGTHTVSLRIQEGCSHLPSCCPSKEQEPPEEWLKWSSASVSPPEPLSHTHHAESCRASKDGPLNSRAISPWSYELDRDLNRVPQDLYHARCLCPHCVSLQTGSHMDPLGNSVPLYHNQTVFYRRPCHGEEGTHRRYCLERRLYRVSLACVCVRPRVMA
uniprot
proteins
function
FUNCTION: Cytokine produced by various cells such as eosinophils, T-helper type 2 (Th2) cells or epithelial cells that plays a role in internal safety of adaptive immune responses by regulating cytokine production (PubMed:11754819, PubMed:35615348). Promotes and augments T-helper type 2 responses locally or systemically (PubMed:35615348). Exerts its activity via its receptor composed of IL17RA and IL17RB for signal transduction (PubMed:18768888). In turn, stimulates the JAK2-STAT5A pathway and promotes the secretion of type-2 associated cytokines including IL4, IL9 and IL13. Also induces the release of IL8, and IL6 from eosinophils through the combined activation of MAPK and NF-kappa-B pathways. Inhibits the differentiation of T-helper (Th17) cells via the production of IL4, IL5 and IL13. {ECO:0000250|UniProtKB:Q9H293, ECO:0000269|PubMed:18768888, ECO:0000269|PubMed:35615348}.
uniprot
proteins
mass_dalton
19210
uniprot
proteins
protein_family
IL-17 family
uniprot
proteins
pubmed
11754819
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18768888
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
35615348
uniprot
proteins
sequence_length
169
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9H293}.
uniprot
proteins