JPH4
entrez
84502
canonical
uniprot
Q96JJ6
canonical
ensembl
ENSG00000092051
resolver
ensp
ENSP00000348648
resolver
ensp
ENSP00000380307
resolver
ensp
ENSP00000598046
resolver
ensp
ENSP00000598049
resolver
enst
ENST00000356300
resolver
enst
ENST00000397118
resolver
enst
ENST00000927987
resolver
enst
ENST00000927990
resolver
genesymbol
JPH4
resolver
genesymbol_syn
JPHL1
resolver
genesymbol_syn
KIAA1831
resolver
hgnc
HGNC:20156
resolver
uniprot
D3DS53
resolver
uniprot
Q8ND44
resolver
uniprot
Q96DQ0
resolver
uniprot_entry
JPH4_HUMAN
resolver
uniprot_sec
D3DS53
resolver
uniprot_sec
Q8ND44
resolver
uniprot_sec
Q96DQ0
resolver
amino_acid_sequence
MSPGGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGVERKSRWTYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSVPYHQAALLRSPRRTSLDSGHSDPPTPPPPLPLPGDEGGSPASGSRGGFVLAGPGDADGASSRKRTPAAGGFFRRSLLLSGLRAGGRRSSLGSKRGSLRSEVSSEVGSTGPPGSEASGPPAAAPPALIEGSATEVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAVEGARRAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGRRPRQDSEGSDTEPLDEDSPGVYENGLTPSEGSPELPSSPASSRQPWRPPACRSPLPPGGDQGPFSSPKAWPEEWGGAGAQAEELAGYEAEDEAGMQGPGPRDGSPLLGGCSDSSGSLREEEGEDEEPLPPLRAPAGTEPEPIAMLVLRGSSSRGPDAGCLTEELGEPAATERPAQPGAANPLVVGAVALLDLSLAFLFSQLLT
uniprot
proteins
function
FUNCTION: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
65861
uniprot
proteins
protein_family
Junctophilin family
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
sequence_length
628
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 607..628; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins