CLEC9A
entrez
283420
canonical
uniprot
Q6UXN8
canonical
ensembl
ENSG00000197992
resolver
ensp
ENSP00000348074
resolver
ensp
ENSP00000576314
resolver
enst
ENST00000355819
resolver
enst
ENST00000906255
resolver
genesymbol
CLEC9A
resolver
hgnc
HGNC:26705
resolver
uniprot
B0ZBM2
resolver
uniprot_entry
CLC9A_HUMAN
resolver
uniprot_sec
B0ZBM2
resolver
amino_acid_sequence
MHEEEIYTSLQWDSPAPDTYQKCLSSNKCSGACCLVMVISCVFCMGLLTASIFLGVKLLQVSTIAMQQQEKLIQQERALLNFTEWKRSCALQMKYCQAFMQNSLSSAHNSSPCPNNWIQNRESCYYVSEIWSIWHTSQENCLKEGSTLLQIESKEEMDFITGSLRKIKGSYDYWVGLSQDGHSGRWLWQDGSSPSPGLLPAERSQSANQVCGYVKSNSLLSSNCSTWKYFICEKYALRSSV
uniprot
proteins
function
FUNCTION: Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. {ECO:0000269|PubMed:18497879, ECO:0000269|PubMed:22483802}.
uniprot
proteins
mass_dalton
27324
uniprot
proteins
mutagenesis
MUTAGEN 131; /note="W->A: Abolishes binding to damaged cells; when associated with A-227."; /evidence="ECO:0000269|PubMed:22483802"; MUTAGEN 227; /note="W->A: Abolishes binding to damaged cells; when associated with A-131."; /evidence="ECO:0000269|PubMed:22483802
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:18408006}.
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
18408006
uniprot
proteins
pubmed
18497879
uniprot
proteins
pubmed
22483802
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:18408006}; Single-pass type II membrane protein {ECO:0000269|PubMed:18408006}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins