TYRO3
entrez
7301
canonical
uniprot
Q06418
canonical
ensembl
ENSG00000092445
resolver
ensp
ENSP00000263798
resolver
ensp
ENSP00000454050
resolver
ensp
ENSP00000792086
resolver
enst
ENST00000263798
resolver
enst
ENST00000559066
resolver
genesymbol
TYRO3
resolver
genesymbol_syn
BYK
resolver
genesymbol_syn
DTK
resolver
genesymbol_syn
RSE
resolver
genesymbol_syn
SKY
resolver
genesymbol_syn
TIF
resolver
hgnc
HGNC:12446
resolver
uniprot
H0YNK6
resolver
uniprot
O14953
resolver
uniprot
Q86VR3
resolver
uniprot_entry
H0YNK6_HUMAN
resolver
uniprot_entry
TYRO3_HUMAN
resolver
uniprot_sec
O14953
resolver
uniprot_sec
Q86VR3
resolver
amino_acid_sequence
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269|PubMed:20546121}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:22673088, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688}.
uniprot
proteins
mass_dalton
96905
uniprot
proteins
mutagenesis
MUTAGEN 99; /note="I->R: Abolishes dimerization."; /evidence="ECO:0000269|PubMed:14623883
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated.
uniprot
proteins
protein_family
AXL/UFO subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
14623883
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16737840
uniprot
proteins
pubmed
17005688
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18421305
uniprot
proteins
pubmed
20546121
uniprot
proteins
pubmed
22156524
uniprot
proteins
pubmed
22673088
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25277499
uniprot
proteins
pubmed
7511603
uniprot
proteins
pubmed
7537495
uniprot
proteins
pubmed
7634325
uniprot
proteins
pubmed
7857658
uniprot
proteins
pubmed
8108112
uniprot
proteins
pubmed
8262388
uniprot
proteins
pubmed
9175267
uniprot
proteins
sequence_length
890
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 430..450; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins