RUSC1
entrez
23623
canonical
uniprot
Q9BVN2
canonical
ensembl
ENSG00000160753
resolver
ensp
ENSP00000292254
resolver
ensp
ENSP00000357331
resolver
ensp
ENSP00000357333
resolver
ensp
ENSP00000357336
resolver
ensp
ENSP00000357338
resolver
ensp
ENSP00000480831
resolver
ensp
ENSP00000512744
resolver
ensp
ENSP00000548433
resolver
ensp
ENSP00000668689
resolver
enst
ENST00000696599
resolver
genesymbol
RUSC1
resolver
genesymbol_syn
NESCA
resolver
hgnc
HGNC:17153
resolver
uniprot
A0A8Q3SIT1
resolver
uniprot
B3KWM9
resolver
uniprot
B4DQB8
resolver
uniprot
Q5T9U9
resolver
uniprot
Q5T9V0
resolver
uniprot
Q5T9V1
resolver
uniprot
Q5T9V2
resolver
uniprot
Q9UPY4
resolver
uniprot
Q9Y4T5
resolver
uniprot_entry
A0A8Q3SIT1_HUMAN
resolver
uniprot_entry
B4DQB8_HUMAN
resolver
uniprot_entry
RUSC1_HUMAN
resolver
uniprot_sec
B3KWM9
resolver
uniprot_sec
Q5T9U9
resolver
uniprot_sec
Q5T9V0
resolver
uniprot_sec
Q5T9V1
resolver
uniprot_sec
Q5T9V2
resolver
uniprot_sec
Q9UPY4
resolver
uniprot_sec
Q9Y4T5
resolver
amino_acid_sequence
MLSPQRALLCNLNHIHLQHVSLGLHLSRRPELQEGPLSTPPPPGDTGGKESRGPCSGTLVDANSNSPAVPCRCCQEHGPGLENRQDPSQEEEGAASPSDPGCSSSLSSCSDLSPDESPVSVYLRDLPGDEDAHPQPSIIPLEQGSPLASAGPGTCSPDSFCCSPDSCSGASSSPDPGLDSNCNALTTCQDVPSPGLEEEDERAEQDLPTSELLEADDGKIDAGKTEPSWKINPIWKIDTEKTKAEWKTTENNNTGWKNNGNVNSSWKSEPEKFDSGWKTNTRITDSGSKTDAGKIDGGWRSDVSEEPVPHRTITSFHELAQKRKRGPGLPLVPQAKKDRSDWLIVFSPDTELPPSGSPGGSSAPPREVTTFKELRSRSRAPAPPVPPRDPPVGWALVPPRPPPPPVPPRRKKNRPGLQPIAEGQSEEGRAVSPAAGEEAPAAKEPGAQAGLEVRSSWSFAGVPGAQRLWMAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLTTLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPLSSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGGCPSLSTELLLLLQPLSVLTFHLDLLFEHHHHLPLGPPQAPAPPGPPPALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLPTPGSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQERPLPTDEMAPGRGLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVPVGYTSLVL
uniprot
proteins
function
FUNCTION: Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network (PubMed:30262884). Signaling adapter which plays a role in neuronal differentiation (PubMed:15024033). Involved in regulation of NGF-dependent neurite outgrowth (PubMed:15024033). May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins (By similarity). Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK (PubMed:15024033). Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway (PubMed:19365808). {ECO:0000250|UniProtKB:Q8BG26, ECO:0000269|PubMed:15024033, ECO:0000269|PubMed:19365808, ECO:0000269|PubMed:30262884}.
uniprot
proteins
mass_dalton
96444
uniprot
proteins
mutagenesis
MUTAGEN 531; /note="L->A: Abrogates nuclear redistribution."; /evidence="ECO:0000269|PubMed:15024033
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues following nuclear translocation. {ECO:0000269|PubMed:15024033}.; PTM: Polyubiquitinated; polyubiquitination involves TRAF6. {ECO:0000269|PubMed:19365808}.
uniprot
proteins
pubmed
10760598
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15024033
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19365808
uniprot
proteins
pubmed
30262884
uniprot
proteins
sequence_length
902
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15024033}. Nucleus {ECO:0000269|PubMed:15024033}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8BG26}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q8BG26}. Early endosome {ECO:0000250|UniProtKB:Q8BG26}. Postsynaptic density {ECO:0000250|UniProtKB:Q8BG26}. Golgi apparatus {ECO:0000250|UniProtKB:Q8BG26}. Note=Translocated to the nuclear envelope upon stimulation with NGF (PubMed:15024033). Associated with membranes and microtubules (By similarity). {ECO:0000250|UniProtKB:Q8BG26, ECO:0000269|PubMed:15024033}.
uniprot
proteins