Letm1
entrez
305457
canonical
uniprot
Q5XIN6
canonical
ensembl
ENSRNOG00000016427
resolver
ensembl
ENSRNOG00055031379
resolver
ensembl
ENSRNOG00060022858
resolver
ensembl
ENSRNOG00065029989
resolver
ensp
ENSRNOP00000022540
resolver
ensp
ENSRNOP00055044922
resolver
ensp
ENSRNOP00060032863
resolver
ensp
ENSRNOP00065042657
resolver
enst
ENSRNOT00000022540
resolver
enst
ENSRNOT00055054345
resolver
enst
ENSRNOT00060039741
resolver
enst
ENSRNOT00065051826
resolver
genesymbol
Letm1
resolver
uniprot_entry
LETM1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by ruthenium red or its derivative Ru360. {ECO:0000250|UniProtKB:O95202}.
uniprot
proteins
amino_acid_sequence
MASILLRSCRGRGPARLASPRAASPRGSLRDRACLSCTRTVGLTSHESVLSRCCTPANPVYLYFKSEPLSCWTQRPECQGTVARAAWTPASARLVVTGPQYLPVRGWHSSSPLGEDSMIEKSLKSLKDKNKKLEEGGPVYSPPAQVVVKKSLGQKILDELKHYYHGFRLLWIDTKIAARMLWRILNGHTLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVVVKLFPNMLPSTFETQSIKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGNATKDFSAFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLISEEGVDSLTVKELQAACRARGMRALGVTEDRLKGQLKQWLDLHLYHEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKAAEVEGEQVDNKAKLEATLQEEAAIQQEHLEELKRAAETAKDIQPEVAEATVPGRPGAELQPKMVDVIPPSEILKDTAPVLEGLKGEEITKEEIDILSDACSKLKEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGDEKYIEESTASKRLSKRVQQMIGQIDGLITQLETTQQNGKLDPAAASSPTGESVISVDELISAMKQIKHIPEHKLISLTSALDENKDGNINIDDLVKVIDLVNKEDVQISTTQVAEIVATLEKEEKVEEKEKAKEKAEKEAAEVKN
uniprot
proteins
function
FUNCTION: Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (By similarity). Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Also functions as an electroneutral mitochondrial proton/potassium exchanger (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). Essential for early embryonic development (By similarity). {ECO:0000250|UniProtKB:O95202, ECO:0000250|UniProtKB:Q9Z2I0}.
uniprot
proteins
mass_dalton
83060
uniprot
proteins
post_translational_modification
PTM: PINK1-mediated phosphorylation at Thr-191, positively regulates its mitochondrial calcium transport activity. {ECO:0000250|UniProtKB:O95202}.
uniprot
proteins
protein_family
LETM1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18628306
uniprot
proteins
sequence_length
739
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9Z2I0}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 208..228; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins