ADH4
entrez
127
canonical
uniprot
P08319
canonical
ensembl
ENSG00000198099
resolver
ensp
ENSP00000265512
resolver
ensp
ENSP00000424630
resolver
ensp
ENSP00000425416
resolver
genesymbol
ADH4
resolver
genesymbol
HEL-S-4
resolver
genesymbol_syn
ADH2
resolver
hgnc
HGNC:252
resolver
uniprot
A8K470
resolver
uniprot
B4DIE7
resolver
uniprot
C9J4A9
resolver
uniprot
Q8TCD7
resolver
uniprot
V9HVX7
resolver
uniprot_entry
ADH4_HUMAN
resolver
uniprot_entry
V9HVX7_HUMAN
resolver
uniprot_sec
A8K470
resolver
uniprot_sec
B4DIE7
resolver
uniprot_sec
C9J4A9
resolver
uniprot_sec
Q8TCD7
resolver
activity_regulation
ACTIVITY REGULATION: Oxydation of 20-HETE is inhibited by low concentrations of N-heptylformamide (PubMed:16081420). Oxydation of 20-HETE is a decreased by 55-65% by either all-trans-retinol or all-trans-retinoic acid. Strongly inhibited by omega-hydroxy fatty acids (By similarity). {ECO:0000250|UniProtKB:Q9QYY9, ECO:0000269|PubMed:16081420}.
uniprot
proteins
amino_acid_sequence
MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSVRTILIF
uniprot
proteins
ec_number
1.1.1.105
uniprot
proteins
function
FUNCTION: Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Also catalyzes the reduction of benzoquinones (PubMed:10514444). {ECO:0000269|PubMed:10514444, ECO:0000269|PubMed:16081420, ECO:0000269|PubMed:17279314}.
uniprot
proteins
mass_dalton
40222
uniprot
proteins
protein_family
Class-II subfamily
uniprot
proteins
protein_family
Zinc-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
10514444
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16081420
uniprot
proteins
pubmed
17279314
uniprot
proteins
pubmed
1889753
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
3036213
uniprot
proteins
sequence_length
380
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins