Ireb2
entrez
64831
canonical
uniprot
Q62751
canonical
ensembl
ENSRNOG00000013271
resolver
ensembl
ENSRNOG00055031180
resolver
ensembl
ENSRNOG00060014254
resolver
ensembl
ENSRNOG00065018777
resolver
ensp
ENSRNOP00000017900
resolver
ensp
ENSRNOP00000070223
resolver
ensp
ENSRNOP00055044719
resolver
ensp
ENSRNOP00060019477
resolver
ensp
ENSRNOP00065025132
resolver
enst
ENSRNOT00000017900
resolver
enst
ENSRNOT00000077922
resolver
enst
ENSRNOT00055054067
resolver
enst
ENSRNOT00060024400
resolver
enst
ENSRNOT00065031535
resolver
genesymbol
Ireb2
resolver
genesymbol_syn
Irp2
resolver
uniprot
A0A0G2JXC9
resolver
uniprot
Q66HL4
resolver
uniprot_entry
A0A0G2JXC9_RAT
resolver
uniprot_entry
IREB2_RAT
resolver
uniprot_sec
Q66HL4
resolver
amino_acid_sequence
MDSPSAGYTFEYLIETLNGSSQKKFFNVPKLGGTKYDILPYSIRVLLEAAVRNCDGFLMKKEDVINILDWKTKQSNVEVPFFPARVVLQDFTGIPAMVDFAAMREAVKTLGGDPKKVHPACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDSGELSRNSGTFSSQIENTPVLCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSGAFKNVAVIPPGTGMAHQVNLEHLSRVVFEEADLLFPDSVIGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGCELTGSSNAFVTSIDIVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEHTGFDKTKLESMEEYLKAVKLFRNDENSSEPEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQVAAEKQSDTVSVRYDGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVETGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAPLSEAILNAVKQGDLVTCGVLSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDSTGKNIYLHDIWPSREEVHQIEEEHVILSMFKALKEKVEMGNKRWNSLDAPDSVLFPWDVKSTYIRCPSFFDKLTKEPAASQPIENAHVLLYLGDSVTTDHISPAGSIARSSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLEFLPGENADSLGLSGREVFSLSFPEELFPGITLNIKTSTGKEFSVIAAFENDVEITLYKHGGLLNFVARKFL
uniprot
proteins
function
FUNCTION: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. {ECO:0000250|UniProtKB:P48200}.
uniprot
proteins
mass_dalton
104802
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen. Ubiquitinated by a SCF complex containing FBXL5. Upon iron and oxygen depletion FBXL5 is degraded, preventing ubiquitination and allowing its RNA-binding activity (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Aconitase/IPM isomerase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7622457
uniprot
proteins
pubmed
7665579
uniprot
proteins
sequence_length
963
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins