Ifnl2
entrez
330496
canonical
uniprot
Q4VK74
canonical
ensembl
ENSMUSG00000059128
resolver
ensp
ENSMUSP00000080384
resolver
enst
ENSMUST00000081684
resolver
genesymbol
Ifnl2
resolver
genesymbol_syn
Il28a
resolver
uniprot
E9Q2S2
resolver
uniprot_entry
IFNL2_MOUSE
resolver
uniprot_sec
E9Q2S2
resolver
amino_acid_sequence
MLLLLLPLLLAAVLTRTQADPVPRATRLPVEAKDCHIAQFKSLSPKELQAFKKAKDAIEKRLLEKDLRCSSHLFPRAWDLKQLQVQERPKALQAEVALTLKVWENMTDSALATILGQPLHTLSHIHSQLQTCTQLQATAEPRSPSRRLSRWLHRLQEAQSKETPGCLEASVTSNLFRLLTRDLKCVANGDQCV
uniprot
proteins
function
FUNCTION: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. {ECO:0000269|PubMed:15914836, ECO:0000269|PubMed:16618774, ECO:0000269|PubMed:18250457, ECO:0000269|PubMed:21518880}.
uniprot
proteins
mass_dalton
21740
uniprot
proteins
protein_family
Type-III (or lambda) interferon family
uniprot
proteins
pubmed
15914836
uniprot
proteins
pubmed
16618774
uniprot
proteins
pubmed
18250457
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20712453
uniprot
proteins
pubmed
21518880
uniprot
proteins
pubmed
24751921
uniprot
proteins
sequence_length
193
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IZJ0}.
uniprot
proteins