CDC2L2
entrez
728642
canonical
uniprot
Q9UQ88
canonical
ensembl
ENSG00000008128
resolver
ensp
ENSP00000350403
resolver
ensp
ENSP00000351629
resolver
ensp
ENSP00000367900
resolver
ensp
ENSP00000384442
resolver
enst
ENST00000357760
resolver
genesymbol
CDC2L2
resolver
genesymbol
CDK11A
resolver
genesymbol_syn
CDC2L2
resolver
genesymbol_syn
CDC2L3
resolver
genesymbol_syn
PITSLREB
resolver
hgnc
HGNC:1730
resolver
uniprot
O95227
resolver
uniprot
O95228
resolver
uniprot
O96012
resolver
uniprot
Q12821
resolver
uniprot
Q12853
resolver
uniprot
Q12854
resolver
uniprot
Q2TAJ0
resolver
uniprot
Q4VBY6
resolver
uniprot
Q5QPR0
resolver
uniprot
Q5QPR1
resolver
uniprot
Q5QPR2
resolver
uniprot
Q5QPR3
resolver
uniprot
Q9UBC4
resolver
uniprot
Q9UBI3
resolver
uniprot
Q9UEI1
resolver
uniprot
Q9UEI2
resolver
uniprot
Q9UP53
resolver
uniprot
Q9UP54
resolver
uniprot
Q9UP55
resolver
uniprot
Q9UP56
resolver
uniprot
Q9UQ86
resolver
uniprot
Q9UQ87
resolver
uniprot
Q9UQ89
resolver
uniprot_entry
CD11A_HUMAN
resolver
uniprot_entry
Q4VBY6_HUMAN
resolver
uniprot_entry
Q5QPR3_HUMAN
resolver
uniprot_sec
O95227
resolver
uniprot_sec
O95228
resolver
uniprot_sec
O96012
resolver
uniprot_sec
Q12821
resolver
uniprot_sec
Q12853
resolver
uniprot_sec
Q12854
resolver
uniprot_sec
Q2TAJ0
resolver
uniprot_sec
Q5QPR0
resolver
uniprot_sec
Q5QPR1
resolver
uniprot_sec
Q5QPR2
resolver
uniprot_sec
Q9UBC4
resolver
uniprot_sec
Q9UBI3
resolver
uniprot_sec
Q9UEI1
resolver
uniprot_sec
Q9UEI2
resolver
uniprot_sec
Q9UP53
resolver
uniprot_sec
Q9UP54
resolver
uniprot_sec
Q9UP55
resolver
uniprot_sec
Q9UP56
resolver
uniprot_sec
Q9UQ86
resolver
uniprot_sec
Q9UQ87
resolver
uniprot_sec
Q9UQ89
resolver
activity_regulation
ACTIVITY REGULATION: Phosphorylation at Thr-436 or Tyr-437 inactivates the enzyme, while phosphorylation at Thr-583 activates it (By similarity). CDK11 (CDK11A and/or CDK11B) is specifically inhibited by the anticancer agent OTS964 (PubMed:31511426, PubMed:36104565, PubMed:36327972). {ECO:0000250|UniProtKB:P06493, ECO:0000269|PubMed:31511426, ECO:0000269|PubMed:36104565, ECO:0000269|PubMed:36327972}.
uniprot
proteins
amino_acid_sequence
MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
uniprot
proteins
ec_number
2.7.11.22
uniprot
proteins
ec_number
2.7.11.23
uniprot
proteins
function
FUNCTION: Cyclin-dependent protein kinase that acts as a regulator of transcription and pre-mRNA splicing (PubMed:12501247, PubMed:32367068, PubMed:36104565, PubMed:40858114). Acts as a key regulator of pre-mRNA splicing by mediating phosphorylation of SF3B1, enabling the association between SF3B1 and U5 and U6 snRNAs in the activated spliceosome, thereby promoting spliceosome assembly (PubMed:36104565, PubMed:38059508). Also acts as a regulator of transcription by phosphorylating 'Ser-2' of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:32367068, PubMed:40858114). Involved in replication-dependent transcription of histone genes: binds to histone genes and phosphorylates POLR2A at 'Ser-2' of the CTD to specifically control transcriptional elongation of histones and recruitment of 3'-end processing factors (PubMed:32367068). Part of a transcription checkpoint upstream of CDK9, which regulates promoter-proximal pausing by RNA polymerase II, a transcription halt following transcription initiation, but prior to elongation (PubMed:40858114). Probably regulates promoter-proximal pausing by mediating phosphorylation of POLR2A at 'Ser-2' of the CTD (PubMed:40858114). {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:32367068, ECO:0000269|PubMed:36104565, ECO:0000269|PubMed:38059508, ECO:0000269|PubMed:40858114}.; FUNCTION: [Isoform SV6]: Isoform expressed in a non-cell cycle-dependent manner. {ECO:0000269|PubMed:12624090}.; FUNCTION: [Isoform 4]: Isoform specifically expressed during the G2-M phases of the cell cycle (PubMed:12082095). Phosphorylates 'Ser-2' of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:38019613). Promotes centromeric transcription to maintain centromeric cohesion during mitosis (PubMed:24436071, PubMed:38019613). {ECO:0000269|PubMed:12082095, ECO:0000269|PubMed:24436071, ECO:0000269|PubMed:38019613}.
uniprot
proteins
mass_dalton
91362
uniprot
proteins
post_translational_modification
PTM: [Isoform SV6]: During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins. {ECO:0000269|PubMed:12624090}.
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10882096
uniprot
proteins
pubmed
11980906
uniprot
proteins
pubmed
12082095
uniprot
proteins
pubmed
12501247
uniprot
proteins
pubmed
12624090
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
24436071
uniprot
proteins
pubmed
31511426
uniprot
proteins
pubmed
32367068
uniprot
proteins
pubmed
36104565
uniprot
proteins
pubmed
36327972
uniprot
proteins
pubmed
38019613
uniprot
proteins
pubmed
38059508
uniprot
proteins
pubmed
40858114
uniprot
proteins
pubmed
8195233
uniprot
proteins
pubmed
9750192
uniprot
proteins
sequence_length
783
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8195233}. Chromosome {ECO:0000269|PubMed:32367068, ECO:0000269|PubMed:40858114}. Cytoplasm {ECO:0000269|PubMed:8195233}. Note=Localizes to transcription start site (TSS) proximal regions. {ECO:0000269|PubMed:40858114}.; SUBCELLULAR LOCATION: [Isoform SV6]: Nucleus {ECO:0000269|PubMed:12501247}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus {ECO:0000269|PubMed:12082095}. Chromosome, centromere {ECO:0000269|PubMed:24436071, ECO:0000269|PubMed:38019613}.
uniprot
proteins