Pcbp2
entrez
18521
canonical
uniprot
Q61990
canonical
ensembl
ENSMUSG00000056851
resolver
ensp
ENSMUSP00000076294
resolver
ensp
ENSMUSP00000104466
resolver
ensp
ENSMUSP00000155038
resolver
ensp
ENSMUSP00000155072
resolver
ensp
ENSMUSP00000155292
resolver
ensp
ENSMUSP00000155430
resolver
ensp
ENSMUSP00000155654
resolver
ensp
ENSMUSP00000155789
resolver
ensp
ENSMUSP00000159956
resolver
ensp
ENSMUSP00000178340
resolver
ensp
ENSMUSP00000178342
resolver
ensp
ENSMUSP00000178343
resolver
ensp
ENSMUSP00000178345
resolver
ensp
ENSMUSP00000178347
resolver
ensp
ENSMUSP00000178351
resolver
ensp
ENSMUSP00000178361
resolver
ensp
ENSMUSP00000178362
resolver
ensp
ENSMUSP00000178363
resolver
ensp
ENSMUSP00000178364
resolver
ensp
ENSMUSP00000178365
resolver
enst
ENSMUST00000108838
resolver
enst
ENSMUST00000229802
resolver
enst
ENSMUST00000229918
resolver
enst
ENSMUST00000230114
resolver
enst
ENSMUST00000249860
resolver
genesymbol
Pcbp2
resolver
genesymbol_syn
Cbp
resolver
genesymbol_syn
Hnrnpx
resolver
genesymbol_syn
Hnrpx
resolver
uniprot
A0A2R8VHP9
resolver
uniprot
A0A2R8W737
resolver
uniprot
A0A2U3TZ65
resolver
uniprot
A0AAQ4VMQ7
resolver
uniprot
B2M1R7
resolver
uniprot
Q3TT81
resolver
uniprot
Q61383
resolver
uniprot
Q62042
resolver
uniprot_entry
A0A2R8VHP9_MOUSE
resolver
uniprot_entry
A0A2R8W737_MOUSE
resolver
uniprot_entry
A0A2U3TZ65_MOUSE
resolver
uniprot_entry
A0AAQ4VMQ7_MOUSE
resolver
uniprot_entry
B2M1R7_MOUSE
resolver
uniprot_entry
PCBP2_MOUSE
resolver
uniprot_entry
Q3TT81_MOUSE
resolver
uniprot_sec
Q61383
resolver
uniprot_sec
Q62042
resolver
amino_acid_sequence
MDTGVIEGGLNVTLTIRLLMHGKEVGSIIGKKGESVKKMREESGARINISEGNCPERIITLAGPTNAIFKAFAMIIDKLEEDISSSMTNSTAASRPPVTLRLVVPASQCGSLIGKGGCKIKEIRESTGAQVQVAGDMLPNSTERAITIAGIPQSIIECVKQICVVMLESPPKGVTIPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSETGGMGSS
uniprot
proteins
function
FUNCTION: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:8208614, PubMed:8367306). Major cellular poly(rC)-binding protein (By similarity). Also binds poly(rU) (By similarity). Acts as a negative regulator of antiviral signaling (By similarity). Negatively regulates cellular antiviral responses mediated by MAVS signaling (By similarity). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (By similarity). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (By similarity). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (PubMed:34180713). {ECO:0000250|UniProtKB:Q15366, ECO:0000269|PubMed:34180713, ECO:0000269|PubMed:8208614, ECO:0000269|PubMed:8367306}.
uniprot
proteins
mass_dalton
38222
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity. {ECO:0000250|UniProtKB:Q15366}.
uniprot
proteins
pubmed
10936052
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26527618
uniprot
proteins
pubmed
34180713
uniprot
proteins
pubmed
8208614
uniprot
proteins
pubmed
8367306
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15366}. Cytoplasm {ECO:0000250|UniProtKB:Q15366}. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm. {ECO:0000250|UniProtKB:Q15366}.
uniprot
proteins