Litaf
entrez
56722
canonical
uniprot
Q9JLJ0
canonical
ensembl
ENSMUSG00000022500
resolver
ensp
ENSMUSP00000023143
resolver
ensp
ENSMUSP00000112667
resolver
enst
ENSMUST00000023143
resolver
enst
ENSMUST00000117360
resolver
genesymbol
Litaf
resolver
genesymbol_syn
N4wbp3
resolver
genesymbol_syn
Tbx1
resolver
uniprot
Q9EQI0
resolver
uniprot_entry
LITAF_MOUSE
resolver
uniprot_sec
Q9EQI0
resolver
amino_acid_sequence
MSAPGPYQAAAGPSVVPTAPPTYEETVGVNSYYPTPPAPMPGPATGLITGPDGKGMNPPSYYTQPVPVPNANAIAVQTVYVQQPVSFYDRPVQMCCPSCSKMIVTQLSYNAGALTWLSCGSLCLLGCVAGCCFIPFCVDALQDVDHYCPNCKALLGTYKRL
uniprot
proteins
function
FUNCTION: Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps down-regulate downstream signaling cascades (PubMed:23166352). Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4 (By similarity). May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005, PubMed:21980379). May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:12355436, PubMed:15025820, PubMed:16954198, PubMed:21980379, PubMed:22160695). {ECO:0000250|UniProtKB:Q99732, ECO:0000269|PubMed:12355436, ECO:0000269|PubMed:15025820, ECO:0000269|PubMed:15793005, ECO:0000269|PubMed:16954198, ECO:0000269|PubMed:21980379, ECO:0000269|PubMed:23166352}.
uniprot
proteins
mass_dalton
16946
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="Y->A: Abolishes interaction with NEDD4."; /evidence="ECO:0000269|PubMed:11042109"; MUTAGEN 61; /note="Y->A: No effect on interaction with NEDD4."; /evidence="ECO:0000269|PubMed:11042109
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues in response to EGF. {ECO:0000250|UniProtKB:Q99732}.
uniprot
proteins
protein_family
CDIP1/LITAF family
uniprot
proteins
pubmed
11042109
uniprot
proteins
pubmed
12355436
uniprot
proteins
pubmed
15025820
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15793005
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16954198
uniprot
proteins
pubmed
21980379
uniprot
proteins
pubmed
22160695
uniprot
proteins
pubmed
22729949
uniprot
proteins
pubmed
23166352
uniprot
proteins
sequence_length
161
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99732}. Nucleus {ECO:0000250|UniProtKB:Q99732}. Lysosome membrane {ECO:0000250|UniProtKB:Q99732}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99732}; Cytoplasmic side {ECO:0000250|UniProtKB:Q99732}. Early endosome membrane {ECO:0000250|UniProtKB:Q99732}. Late endosome membrane {ECO:0000250|UniProtKB:Q99732}. Endosome membrane {ECO:0000250|UniProtKB:Q99732}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99732}; Cytoplasmic side {ECO:0000250|UniProtKB:Q99732}. Cell membrane {ECO:0000250|UniProtKB:Q99732}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99732}; Cytoplasmic side {ECO:0000250|UniProtKB:Q99732}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q99732}. Note=Associated with membranes of lysosomes, early and late endosomes. Can translocate from the cytoplasm into the nucleus (By similarity). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (PubMed:22729949). {ECO:0000250|UniProtKB:Q99732, ECO:0000269|PubMed:22729949}.
uniprot
proteins