Cttn
entrez
60465
canonical
uniprot
Q66HL2
canonical
ensembl
ENSRNOG00000050994
resolver
ensembl
ENSRNOG00055019932
resolver
ensembl
ENSRNOG00060029445
resolver
ensembl
ENSRNOG00065027742
resolver
ensp
ENSRNOP00000050255
resolver
ensp
ENSRNOP00000051742
resolver
ensp
ENSRNOP00000075952
resolver
ensp
ENSRNOP00055028036
resolver
ensp
ENSRNOP00060044034
resolver
ensp
ENSRNOP00065040081
resolver
enst
ENSRNOT00000047669
resolver
enst
ENSRNOT00000092916
resolver
enst
ENSRNOT00055034606
resolver
enst
ENSRNOT00060052969
resolver
enst
ENSRNOT00065048891
resolver
genesymbol
Cttn
resolver
uniprot
A0A8L2URS9
resolver
uniprot
D3ZRB0
resolver
uniprot_entry
A0A8L2URS9_RAT
resolver
uniprot_entry
SRC8_RAT
resolver
uniprot_sec
D3ZRB0
resolver
amino_acid_sequence
MWKASAGHAVSITQDDGGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQKDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYAKGFGGKYGVQKDRMDKNASTFEEVVQVPSAYQKTVPIEAVTSKTSNIRANFENLAKEREQEDRRKAEAERAQRMAQERQEQEEARRKLEEQARAKKQTPPASPSPQPAEDRPPSSPIYEDAAPLKAEPSYGSSEPEPEYSTEAAGLPEASNQQGLAYTSEPVYETTEVPGHYQAEDDTYDGYESDLGITAIALYDYQAAGDDEISFDPDDVITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ
uniprot
proteins
function
FUNCTION: Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:18768925). Plays a role in the formation of lamellipodia and in cell migration (PubMed:18768925). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (PubMed:21210813). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (PubMed:18768925, PubMed:22952866). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (By similarity). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (PubMed:12612086, PubMed:19995918). Required for stabilization of KCNH1 channels at the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q14247, ECO:0000269|PubMed:12612086, ECO:0000269|PubMed:18768925, ECO:0000269|PubMed:19995918, ECO:0000269|PubMed:21210813, ECO:0000269|PubMed:22952866}.
uniprot
proteins
mass_dalton
56942
uniprot
proteins
mutagenesis
MUTAGEN 368; /note="S->A: Inhibits actin polymerization; when associated with A-381."; /evidence="ECO:0000269|PubMed:18768925"; MUTAGEN 381; /note="S->A: Inhibits actin polymerization; when associated with A-368."; /evidence="ECO:0000269|PubMed:18768925"; MUTAGEN 384; /note="Y->E: Promotes reorganization of the actin cytoskeleton and cell motility; when associated with E-429 and E-445."; /evidence="ECO:0000269|PubMed:18768925"; MUTAGEN 384; /note="Y->F: Impairs receptor-mediated endocytosis. Increases the stability of focal adhesion and decreases their turnover; when associated with F-429 and F-445."; /evidence="ECO:0000269|PubMed:19995918, ECO:0000269|PubMed:22952866"; MUTAGEN 429; /note="Y->E: Promotes reorganization of the actin cytoskeleton and cell motility; when associated with E-384 and E-445."; /evidence="ECO:0000269|PubMed:18768925"; MUTAGEN 429; /note="Y->F: Impairs receptor-mediated endocytosis. Increases the stability of focal adhesion and decreases their turnover; when associated with F-384 and F-445."; /evidence="ECO:0000269|PubMed:19995918, ECO:0000269|PubMed:22952866"; MUTAGEN 445; /note="Y->E: Promotes reorganization of the actin cytoskeleton and cell motility; when associated with E-384 and E-429."; /evidence="ECO:0000269|PubMed:18768925"; MUTAGEN 445; /note="Y->F: Impairs receptor-mediated endocytosis. Increases the stability of focal adhesion and decreases their turnover; when associated with F-384 and F-429."; /evidence="ECO:0000269|PubMed:19995918, ECO:0000269|PubMed:22952866
uniprot
proteins
post_translational_modification
PTM: Acetylated. {ECO:0000250|UniProtKB:Q14247}.; PTM: Phosphorylated by FER. Phosphorylated in response to FGR activation. Phosphorylation by SRC promotes MYLK binding (By similarity). Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associate with filamentous actin (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation (PubMed:12151401). Phosphorylated by PTK2/FAK1 in response to cell adhesion (PubMed:22952866). {ECO:0000250|UniProtKB:Q14247, ECO:0000250|UniProtKB:Q60598, ECO:0000269|PubMed:12151401, ECO:0000269|PubMed:19995918, ECO:0000269|PubMed:22952866}.
uniprot
proteins
pubmed
12151401
uniprot
proteins
pubmed
12612086
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17959782
uniprot
proteins
pubmed
18768925
uniprot
proteins
pubmed
19995918
uniprot
proteins
pubmed
21210813
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
22952866
uniprot
proteins
pubmed
23144454
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q14247}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q14247}. Cell projection, ruffle {ECO:0000250}. Cell projection, dendrite. Cell projection {ECO:0000269|PubMed:21210813}. Cell membrane {ECO:0000269|PubMed:12612086, ECO:0000269|PubMed:19995918, ECO:0000269|PubMed:21210813}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, podosome {ECO:0000250|UniProtKB:Q01406}. Cell junction {ECO:0000269|PubMed:21210813}. Cell junction, focal adhesion {ECO:0000269|PubMed:18768925, ECO:0000269|PubMed:22952866}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:12612086, ECO:0000269|PubMed:19995918}. Cell projection, dendritic spine {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000269|PubMed:12612086}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q01406}. Note=Colocalizes transiently with PTK2/FAK1 at focal adhesions (PubMed:22952866). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers. In the presence of CTTNBP2, localizes at the cell cortex. In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity). Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (PubMed:21210813). {ECO:0000250, ECO:0000269|PubMed:21210813, ECO:0000269|PubMed:22952866}.
uniprot
proteins