Afmid
entrez
71562
canonical
uniprot
Q8K4H1
canonical
ensembl
ENSMUSG00000017718
resolver
ensp
ENSMUSP00000073102
resolver
ensp
ENSMUSP00000119310
resolver
genesymbol
Afmid
resolver
uniprot
B1AQK9
resolver
uniprot
Q80XP3
resolver
uniprot
Q8R1K6
resolver
uniprot_entry
KFA_MOUSE
resolver
uniprot_sec
B1AQK9
resolver
uniprot_sec
Q80XP3
resolver
uniprot_sec
Q8R1K6
resolver
amino_acid_sequence
MAFPSLSAGQNPWRNLSSEELEKQYSPSRWVIHTKPEEVVGNFVQIGSQATQKARATRRNQLDVPYGDGEGEKLDIYFPDEDSKAFPLFLFLHGGYWQSGSKDDSAFMVNPLTAQGIVVVIVAYDIAPKGTLDQMVDQVTRSVVFLQRRYPSNEGIYLCGHSAGAHLAAMVLLARWTKHGVTPNLQGFLLVSGIYDLEPLIATSQNDPLRMTLEDAQRNSPQRHLDVVPAQPVAPACPVLVLVGQHDSPEFHRQSKEFYETLLRVGWKASFQQLRGVDHFDIIENLTREDDVLTQIILKTVFQKL
uniprot
proteins
ec_number
3.5.1.9
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. {ECO:0000255|HAMAP-Rule:MF_03014, ECO:0000269|PubMed:12007602}.
uniprot
proteins
mass_dalton
34229
uniprot
proteins
mutagenesis
MUTAGEN 162; /note="S->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:15935693"; MUTAGEN 247; /note="D->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:15935693"; MUTAGEN 279; /note="H->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:15935693
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. {ECO:0000255|HAMAP-Rule:MF_03014}.
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.
uniprot
proteins
protein_family
Kynurenine formamidase family
uniprot
proteins
pubmed
12007602
uniprot
proteins
pubmed
12411446
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15866519
uniprot
proteins
pubmed
15935693
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_03014, ECO:0000269|PubMed:12411446}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03014, ECO:0000269|PubMed:12411446}. Note=Predominantly cytosolic. Some fraction is nuclear.
uniprot
proteins