PPM1F
entrez
9647
canonical
uniprot
P49593
canonical
ensembl
ENSG00000100034
resolver
ensp
ENSP00000263212
resolver
ensp
ENSP00000384930
resolver
enst
ENST00000407142
resolver
genesymbol
PPM1F
resolver
genesymbol_syn
KIAA0015
resolver
genesymbol_syn
POPX2
resolver
hgnc
HGNC:19388
resolver
uniprot
A8K6G3
resolver
uniprot
B5MCT7
resolver
uniprot
B7Z2C3
resolver
uniprot
Q96PM2
resolver
uniprot_entry
B5MCT7_HUMAN
resolver
uniprot_entry
PPM1F_HUMAN
resolver
uniprot_sec
A8K6G3
resolver
uniprot_sec
B7Z2C3
resolver
uniprot_sec
Q96PM2
resolver
amino_acid_sequence
MSSGAPQKSSPMASGAEETPGFLDTLLQDFPALLNPEDPLPWKAPGTVLSQEEVEGELAELAMGFLGSRKAPPPLAAALAHEAVSQLLQTDLSEFRKLPREEEEEEEDDDEEEKAPVTLLDAQSLAQSFFNRLWEVAGQWQKQVPLAARASQRQWLVSIHAIRNTRRKMEDRHVSLPSFNQLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTDPEGALREAFRRTDQMFLRKAKRERLQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGDVFQKPYVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSGLRVAEELVAAARERGSHDNITVMVVFLRDPQELLEGGNQGEGDPQAEGRRQDLPSSLPEPETQAPPRS
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in PPM1F may be a cause of sclerosing cholangitis, short stature, hypothyroidism, and abnormal tongue pigmentation. {ECO:0000269|PubMed:30250217}.
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.
uniprot
proteins
mass_dalton
49831
uniprot
proteins
protein_family
PP2C family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11559703
uniprot
proteins
pubmed
11864573
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30250217
uniprot
proteins
pubmed
7584026
uniprot
proteins
sequence_length
454
uniprot
proteins