Pi4kb
entrez
107650
canonical
uniprot
Q8BKC8
canonical
ensembl
ENSMUSG00000038861
resolver
ensp
ENSMUSP00000072134
resolver
ensp
ENSMUSP00000102872
resolver
ensp
ENSMUSP00000132150
resolver
genesymbol
Pi4kb
resolver
genesymbol_syn
Pik4cb
resolver
uniprot
Q14CH6
resolver
uniprot
Q14DJ4
resolver
uniprot
Q3TA58
resolver
uniprot
Q68FH2
resolver
uniprot
Q8C146
resolver
uniprot_entry
PI4KB_MOUSE
resolver
uniprot_sec
Q14CH6
resolver
uniprot_sec
Q14DJ4
resolver
uniprot_sec
Q3TA58
resolver
uniprot_sec
Q68FH2
resolver
uniprot_sec
Q8C146
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ. {ECO:0000250|UniProtKB:O02810}.
uniprot
proteins
amino_acid_sequence
MGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGTPLELVNGDGVDNEIRCLDDPPAQIREEEDEMGAGVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFYFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
uniprot
proteins
ec_number
2.7.1.67
uniprot
proteins
function
FUNCTION: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity). May play an important role in the inner ear development. {ECO:0000250|UniProtKB:O08561, ECO:0000250|UniProtKB:Q9UBF8}.
uniprot
proteins
mass_dalton
91515
uniprot
proteins
protein_family
PI3/PI4-kinase family
uniprot
proteins
protein_family
Type III PI4K subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
816
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Rough endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus {ECO:0000250}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9UBF8}. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3, GGA2 is also involved in the recruitment (By similarity). {ECO:0000250|UniProtKB:Q9UBF8}.
uniprot
proteins