DPEP1
entrez
1800
canonical
uniprot
P16444
canonical
ensembl
ENSG00000015413
resolver
ensp
ENSP00000261615
resolver
ensp
ENSP00000376807
resolver
ensp
ENSP00000397313
resolver
ensp
ENSP00000508584
resolver
ensp
ENSP00000546549
resolver
ensp
ENSP00000546550
resolver
ensp
ENSP00000546551
resolver
ensp
ENSP00000546552
resolver
ensp
ENSP00000606288
resolver
ensp
ENSP00000606292
resolver
ensp
ENSP00000606293
resolver
ensp
ENSP00000744686
resolver
ensp
ENSP00000744687
resolver
enst
ENST00000261615
resolver
enst
ENST00000393092
resolver
enst
ENST00000421184
resolver
enst
ENST00000690203
resolver
enst
ENST00000876490
resolver
enst
ENST00000876491
resolver
enst
ENST00000876492
resolver
enst
ENST00000876493
resolver
enst
ENST00000936229
resolver
enst
ENST00000936233
resolver
enst
ENST00000936234
resolver
genesymbol
DPEP1
resolver
genesymbol_syn
MDP
resolver
genesymbol_syn
RDP
resolver
hgnc
HGNC:3002
resolver
uniprot
A0A140VJI3
resolver
uniprot
D3DX80
resolver
uniprot
Q96AK2
resolver
uniprot_entry
A0A140VJI3_HUMAN
resolver
uniprot_entry
DPEP1_HUMAN
resolver
uniprot_sec
D3DX80
resolver
uniprot_sec
Q96AK2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by L-penicillamine (PubMed:31442408). Beta-lactamase activity is inhibited by cilastatin (PubMed:31442408, PubMed:6334084). {ECO:0000269|PubMed:31442408, ECO:0000269|PubMed:6334084}.
uniprot
proteins
amino_acid_sequence
MWSGWWLWPLVAVCTADFFRDEAERIMRDSPVIDGHNDLPWQLLDMFNNRLQDERANLTTLAGTHTNIPKLRAGFVGGQFWSVYTPCDTQNKDAVRRTLEQMDVVHRMCRMYPETFLYVTSSAGIRQAFREGKVASLIGVEGGHSIDSSLGVLRALYQLGMRYLTLTHSCNTPWADNWLVDTGDSEPQSQGLSPFGQRVVKELNRLGVLIDLAHVSVATMKATLQLSRAPVIFSHSSAYSVCASRRNVPDDVLRLVKQTDSLVMVNFYNNYISCTNKANLSQVADHLDHIKEVAGARAVGFGGDFDGVPRVPEGLEDVSKYPDLIAELLRRNWTEAEVKGALADNLLRVFEAVEQASNLTQAPEEEPIPLDQLGGSCRTHYGYSSGASSLHRHWGLLLASLAPLVLCLSLL
uniprot
proteins
ec_number
3.4.13.19
uniprot
proteins
ec_number
3.5.2.6
uniprot
proteins
function
FUNCTION: Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490, PubMed:31442408, PubMed:32325220, PubMed:6334084). Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (PubMed:32325220). Also possesses beta lactamase activity and can hydrolyze the beta-lactam antibiotic imipenem (PubMed:32325220, PubMed:6334084). {ECO:0000250|UniProtKB:P31428, ECO:0000269|PubMed:2303490, ECO:0000269|PubMed:31442408, ECO:0000269|PubMed:32325220, ECO:0000269|PubMed:6334084}.; FUNCTION: Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver. {ECO:0000250|UniProtKB:P31428}.
uniprot
proteins
mass_dalton
45674
uniprot
proteins
mutagenesis
MUTAGEN 141; /note="E->A: Loss of zinc binding."; /evidence="ECO:0000269|PubMed:32325220"; MUTAGEN 141; /note="E->C: Complete loss of activity."; /evidence="ECO:0000269|PubMed:8097406"; MUTAGEN 141; /note="E->D: Abolished dipeptidase activity. Does not affect ability to bind neutrophils."; /evidence="ECO:0000269|PubMed:31442408, ECO:0000269|PubMed:8097406"; MUTAGEN 141; /note="E->Q: Partial loss of activity."; /evidence="ECO:0000269|PubMed:8097406"; MUTAGEN 304; /note="D->L: Loss of ability to hydrolyze cystinyl-bis-glycine."; /evidence="ECO:0000269|PubMed:32325220
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
protein_family
Peptidase M19 family
uniprot
proteins
pubmed
12144777
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
2137335
uniprot
proteins
pubmed
2168407
uniprot
proteins
pubmed
2303490
uniprot
proteins
pubmed
2768222
uniprot
proteins
pubmed
28413640
uniprot
proteins
pubmed
31442408
uniprot
proteins
pubmed
32325220
uniprot
proteins
pubmed
6334084
uniprot
proteins
pubmed
7764673
uniprot
proteins
pubmed
8097406
uniprot
proteins
pubmed
8439558
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:28413640}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2168407}. Cell projection, microvillus membrane {ECO:0000269|PubMed:2168407}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2168407}. Note=Brush border membrane. {ECO:0000250|UniProtKB:P31429}.
uniprot
proteins