Acsl3
entrez
114024
canonical
uniprot
Q63151
canonical
ensembl
ENSRNOG00000014718
resolver
ensp
ENSRNOP00000091017
resolver
genesymbol
Acsl3
resolver
genesymbol_syn
Acs3
resolver
genesymbol_syn
Facl3
resolver
uniprot_entry
ACSL3_RAT
resolver
amino_acid_sequence
MNNHVSSTPSTMKLKQTIHPILLYFIHFIISLYTILTYIPFYFLCESKQEKPNHIKAKPVSSKPDSAYRSVNSMDGLASVLYPGCDTLDKVFMYAKNKFKDKRLLGTREILNEEDEIQPNGKVFKKVILGHYNWLSYEDVFIRALDFGNGLQMLGQKPKANIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHGLNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGVIVHTMAAVQALGVKADVDKKAHSKPLPSDIAVIMYTSGSTGIPKGVMISHSNIIASITGMARRIPRLGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSVLKPTLMAAVPEIMDRIYKNVMNKVNEMSAFQRNLFILAYNYKMEQISKGCSTPLCDRFVFRNVRRLLGGNIRVLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESTGAGTITEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQNVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFDPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLIDNICAYANSYHSYVIGFVVPNQKELTELARTKGFNGTWEELCNSSEMENEVLKVLSEAAISASLEKFEIPLKIRLSPDPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK
uniprot
proteins
ec_number
6.2.1.15
uniprot
proteins
ec_number
6.2.1.2
uniprot
proteins
ec_number
6.2.1.3
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:15683247, PubMed:19737935, PubMed:28209804). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis (PubMed:19737935). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (PubMed:8663269, PubMed:9276691). Both isoforms exhibit the same level of activity (PubMed:9276691). {ECO:0000250, ECO:0000250|UniProtKB:O95573, ECO:0000269|PubMed:15683247, ECO:0000269|PubMed:19737935, ECO:0000269|PubMed:28209804, ECO:0000269|PubMed:8663269, ECO:0000269|PubMed:9276691}.
uniprot
proteins
mass_dalton
80458
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
15683247
uniprot
proteins
pubmed
19737935
uniprot
proteins
pubmed
28209804
uniprot
proteins
pubmed
29196521
uniprot
proteins
pubmed
8663269
uniprot
proteins
pubmed
9276691
uniprot
proteins
sequence_length
720
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins