Nsmce3
entrez
66647
canonical
uniprot
Q9CPR8
canonical
ensembl
ENSMUSG00000070520
resolver
ensp
ENSMUSP00000091889
resolver
enst
ENSMUST00000094331
resolver
genesymbol
Nsmce3
resolver
genesymbol_syn
Mageg1
resolver
genesymbol_syn
Ndnl2
resolver
uniprot
Q569V7
resolver
uniprot
Q9D378
resolver
uniprot_entry
NSE3_MOUSE
resolver
uniprot_sec
Q569V7
resolver
uniprot_sec
Q9D378
resolver
amino_acid_sequence
MLQKPRGRGRPSTQADPERDWGGAGEEGPSTSRAAGGSSQGSRASLSAPTVGPRTQKQLELKVAELVQFLLIKDQKKIPIKRTDILKHVVGDYRDVYPNLLKLAAERLQYVFGYKLVELEPKSHSYILINMLEPVEADAEMRGDQGTPISGLLMIVLGLIFMKGNTITETEVWDFLRRLGVYPTKKHLIFGDPKKLITEDFVRQRYLEYRRIPHTDPVDYELQWGPRTNLETSKMKVLKFVAKVHNQDPKDWPTQYCEALADEESRARPATASAPATSS
uniprot
proteins
function
FUNCTION: Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (PubMed:14593116). {ECO:0000250|UniProtKB:Q96MG7, ECO:0000269|PubMed:14593116}.
uniprot
proteins
mass_dalton
31460
uniprot
proteins
pubmed
11782285
uniprot
proteins
pubmed
14593116
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
279
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14593116}. Nucleus {ECO:0000269|PubMed:14593116}. Chromosome, telomere {ECO:0000250}.
uniprot
proteins