TNLG2A
entrez
8995
canonical
uniprot
Q9UNG2
canonical
ensembl
ENSG00000120337
resolver
ensp
ENSP00000385470
resolver
enst
ENST00000404377
resolver
genesymbol
TNFSF18
resolver
genesymbol
TNLG2A
resolver
genesymbol_syn
AITRL
resolver
genesymbol_syn
GITRL
resolver
genesymbol_syn
TL6
resolver
hgnc
HGNC:11932
resolver
uniprot
A0A0U5JXL4
resolver
uniprot
A9IQG8
resolver
uniprot
O95852
resolver
uniprot
Q6ISV1
resolver
uniprot_entry
A0A0U5JXL4_HUMAN
resolver
uniprot_entry
TNF18_HUMAN
resolver
uniprot_sec
A9IQG8
resolver
uniprot_sec
O95852
resolver
uniprot_sec
Q6ISV1
resolver
amino_acid_sequence
MCLSHLENMPLSHSRTQGAQRSSWKLWLFCSIVMLLFLCSFSWLIFIFLQLETAKEPCMAKFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFIS
uniprot
proteins
function
FUNCTION: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). {ECO:0000250|UniProtKB:Q7TS55, ECO:0000269|PubMed:17449724, ECO:0000269|PubMed:18040044, ECO:0000269|PubMed:23892569}.
uniprot
proteins
mass_dalton
20308
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
10037686
uniprot
proteins
pubmed
10074428
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17449724
uniprot
proteins
pubmed
18040044
uniprot
proteins
pubmed
23892569
uniprot
proteins
sequence_length
177
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17449724}; Single-pass type II membrane protein {ECO:0000269|PubMed:17449724}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..48; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins