Aqp11
entrez
66333
canonical
uniprot
Q8BHH1
canonical
ensembl
ENSMUSG00000042797
resolver
ensp
ENSMUSP00000146215
resolver
enst
ENSMUST00000206389
resolver
genesymbol
Aqp11
resolver
uniprot
Q8JZU1
resolver
uniprot_entry
AQP11_MOUSE
resolver
uniprot_sec
Q8JZU1
resolver
amino_acid_sequence
MSALLGLRPEVQDTCISLGLMLLFVLFVGLARVIARQQLHRPVVHAFVLEFLATFQLCCCTHELQVLSEQDSAHPTWTLTLIYFFSLVHGLTLVGTASNPCGVMMQMILGGMSPEMGAVRLLAQLVSALCSRYCISALWSLSLTKYHYDERILACRNPIHTDMSKAIIIEAICSFIFHSALLHFQEVRTKLRIHLLAALITFLAYAGGSLTGALFNPALALSLHFPCFDELFYKFFVVYWLAPSVGVLMMILMFSFFLPWLHNNQMTNKKE
uniprot
proteins
function
FUNCTION: Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain (PubMed:21118806, PubMed:21251984). In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (PubMed:23275615, PubMed:30656220). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (PubMed:18606867, PubMed:24854278). Plays a role in the proximal tubule function by regulating its endosomal acidification (PubMed:16107722). May play a role in postnatal kidney development (PubMed:18701606, PubMed:23486012, PubMed:27582095). {ECO:0000269|PubMed:16107722, ECO:0000269|PubMed:18606867, ECO:0000269|PubMed:18701606, ECO:0000269|PubMed:21118806, ECO:0000269|PubMed:21251984, ECO:0000269|PubMed:23275615, ECO:0000269|PubMed:23486012, ECO:0000269|PubMed:24854278, ECO:0000269|PubMed:27582095, ECO:0000269|PubMed:30656220}.
uniprot
proteins
mass_dalton
30481
uniprot
proteins
mutagenesis
MUTAGEN 99; /note="N->D: Reduces oligomerization."; /evidence="ECO:0000269|PubMed:23486012"; MUTAGEN 101; /note="C->A: Does not affect endoplasmic reticulum localization. Does not affect plama membrane localization. Reduces oligomerization. Impairs water permeability."; /evidence="ECO:0000269|PubMed:21118806"; MUTAGEN 102; /note="G->V: Does not affect oligomerization formation."; /evidence="ECO:0000269|PubMed:23486012"; MUTAGEN 227; /note="C->S: Homozygous sudden juvenile death syndrome (sjds) mice die before 20 day of age and exhibit severe proximal tubule injury and formation of giant vacuoles in the renal cortex. Interferes with maintenance of AQP11 oligomeric structure. Aqp11 mutant mice developed proximal tubule (PT)-specific mitochondrial injury. Heterozygous sudden juvenile death syndrome (sjds) mice exhibit higher AQP11 levels but are not further increased in response to glucose. Upon glucose treatment, heterozygous Aqp11 mice show increased blood urea nitrogen levels that are prevented by the antioxidant sulforaphane or by phlorizin."; /evidence="ECO:0000269|PubMed:18701606
uniprot
proteins
post_translational_modification
PTM: Not glycosylated. {ECO:0000250|UniProtKB:Q8NBQ7}.
uniprot
proteins
protein_family
AQP11/AQP12 subfamily
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16107722
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18606867
uniprot
proteins
pubmed
18701606
uniprot
proteins
pubmed
19812234
uniprot
proteins
pubmed
21118806
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21251984
uniprot
proteins
pubmed
23275615
uniprot
proteins
pubmed
23486012
uniprot
proteins
pubmed
24854278
uniprot
proteins
pubmed
27107718
uniprot
proteins
pubmed
27258268
uniprot
proteins
pubmed
27582095
uniprot
proteins
pubmed
30656220
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16107722, ECO:0000269|PubMed:21118806, ECO:0000269|PubMed:24854278}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NBQ7}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8NBQ7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NBQ7}. Cell membrane {ECO:0000250|UniProtKB:F6S3G9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NBQ7}. Note=Localizes mainly to the periphery of lipid droplets. Localizes to cytoplasmic vesicles in maturing spermatozoa. It accumulates partly in mitochondrial-associated endoplasmic reticulum membranes. {ECO:0000250|UniProtKB:Q8NBQ7}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..35; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 42..62; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 77..97; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 195..215; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 235..255; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins