SLC22A8
entrez
9376
canonical
uniprot
Q8TCC7
canonical
ensembl
ENSG00000149452
resolver
ensp
ENSP00000337335
resolver
ensp
ENSP00000398548
resolver
ensp
ENSP00000441658
resolver
ensp
ENSP00000443368
resolver
genesymbol
SLC22A8
resolver
genesymbol_syn
OAT3
resolver
hgnc
HGNC:10972
resolver
uniprot
B2R807
resolver
uniprot
B4DPH7
resolver
uniprot
F5GWA8
resolver
uniprot
F5H5J1
resolver
uniprot
O95820
resolver
uniprot
Q59EW9
resolver
uniprot
Q96TC1
resolver
uniprot_entry
B2R807_HUMAN
resolver
uniprot_entry
S22A8_HUMAN
resolver
uniprot_sec
B4DPH7
resolver
uniprot_sec
F5GWA8
resolver
uniprot_sec
F5H5J1
resolver
uniprot_sec
O95820
resolver
uniprot_sec
Q59EW9
resolver
uniprot_sec
Q96TC1
resolver
amino_acid_sequence
MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPWVLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGSS
uniprot
proteins
function
FUNCTION: Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient (PubMed:14586168, PubMed:15644426, PubMed:15846473, PubMed:16455804, PubMed:31553721). Transports organic anions such as estrone 3-sulfate (E1S) and urate in exchange for dicarboxylates such as glutarate or ketoglutarate (2-oxoglutarate) (PubMed:14586168, PubMed:15846473, PubMed:15864504, PubMed:22108572, PubMed:23832370). Plays an important role in the excretion of endogenous and exogenous organic anions, especially from the kidney and the brain (PubMed:11306713, PubMed:14586168, PubMed:15846473). E1S transport is pH- and chloride-dependent and may also involve E1S/cGMP exchange (PubMed:26377792). Responsible for the transport of prostaglandin E2 (PGE2) and prostaglandin F2(alpha) (PGF2(alpha)) in the basolateral side of the renal tubule (PubMed:11907186). Involved in the transport of neuroactive tryptophan metabolites kynurenate and xanthurenate (PubMed:22108572, PubMed:23832370). Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (PubMed:28534121). May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside (PubMed:15644426). May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the antibiotic benzylpenicillin (PCG), the anionic herbicide 2,4-dichloro-phenoxyacetate (2,4-D), the diagnostic agent p-aminohippurate (PAH), the antiviral acyclovir (ACV), and the mycotoxin ochratoxin (OTA), by transporting these exogenous organic anions across the cell membrane in exchange for dicarboxylates such as 2-oxoglutarate (PubMed:11669456, PubMed:15846473, PubMed:16455804). Contributes to the renal uptake of potent uremic toxins (indoxyl sulfate (IS), indole acetate (IA), hippurate/N-benzoylglycine (HA) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)), pravastatin, PCG, E1S and dehydroepiandrosterone sulfate (DHEAS), and is partly involved in the renal uptake of temocaprilat (an angiotensin-converting enzyme (ACE) inhibitor) (PubMed:14675047). May contribute to the release of cortisol in the adrenals (PubMed:15864504). Involved in one of the detoxification systems on the choroid plexus (CP), removes substrates such as E1S or taurocholate (TC), PCG, 2,4-D and PAH, from the cerebrospinal fluid (CSF) to the blood for eventual excretion in urine and bile (By similarity). Also contributes to the uptake of several other organic compounds such as the prostanoids prostaglandin E(2) and prostaglandin F(2-alpha), L-carnitine, and the therapeutic drugs allopurinol, 6-mercaptopurine (6-MP) and 5-fluorouracil (5-FU) (By similarity). Mediates the transport of PAH, PCG, and the statins pravastatin and pitavastatin, from the cerebrum into the blood circulation across the blood-brain barrier (BBB). In summary, plays a role in the efflux of drugs and xenobiotics, helping reduce their undesired toxicological effects on the body (By similarity). {ECO:0000250|UniProtKB:O88909, ECO:0000250|UniProtKB:Q9R1U7, ECO:0000269|PubMed:11306713, ECO:0000269|PubMed:11669456, ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:14586168, ECO:0000269|PubMed:14675047, ECO:0000269|PubMed:15644426, ECO:0000269|PubMed:15846473, ECO:0000269|PubMed:15864504, ECO:0000269|PubMed:16455804, ECO:0000269|PubMed:22108572, ECO:0000269|PubMed:23832370, ECO:0000269|PubMed:26377792, ECO:0000269|PubMed:28534121, ECO:0000269|PubMed:31553721, ECO:0000303|PubMed:15864504}.
uniprot
proteins
mass_dalton
59856
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
10049739
uniprot
proteins
pubmed
11306713
uniprot
proteins
pubmed
11669456
uniprot
proteins
pubmed
11907186
uniprot
proteins
pubmed
11912245
uniprot
proteins
pubmed
12811365
uniprot
proteins
pubmed
14586168
uniprot
proteins
pubmed
14675047
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15644426
uniprot
proteins
pubmed
15846473
uniprot
proteins
pubmed
15864504
uniprot
proteins
pubmed
16291576
uniprot
proteins
pubmed
16455804
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
22108572
uniprot
proteins
pubmed
23832370
uniprot
proteins
pubmed
26377792
uniprot
proteins
pubmed
28534121
uniprot
proteins
pubmed
31553721
uniprot
proteins
sequence_length
542
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:11306713}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes on the brush border membrane of the choroid epithelial cells (By similarity). Localizes to the basolateral membrane of the proximal tubular cells (PubMed:11306713). Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9R1U7, ECO:0000269|PubMed:11306713}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 124..144; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 237..257; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 328..348; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 355..375; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 387..407; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 412..432; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 472..492; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins