KLC1
entrez
3831
canonical
uniprot
Q07866
canonical
ensembl
ENSG00000126214
resolver
ensp
ENSP00000246489
resolver
ensp
ENSP00000334523
resolver
ensp
ENSP00000334618
resolver
ensp
ENSP00000341154
resolver
ensp
ENSP00000369377
resolver
ensp
ENSP00000374394
resolver
ensp
ENSP00000412693
resolver
ensp
ENSP00000414982
resolver
ensp
ENSP00000450617
resolver
ensp
ENSP00000450648
resolver
ensp
ENSP00000451242
resolver
ensp
ENSP00000452481
resolver
ensp
ENSP00000551753
resolver
ensp
ENSP00000551755
resolver
ensp
ENSP00000551757
resolver
ensp
ENSP00000551762
resolver
ensp
ENSP00000653287
resolver
ensp
ENSP00000653288
resolver
ensp
ENSP00000653295
resolver
ensp
ENSP00000653296
resolver
ensp
ENSP00000685840
resolver
ensp
ENSP00000685841
resolver
ensp
ENSP00000787010
resolver
ensp
ENSP00000787012
resolver
ensp
ENSP00000799148
resolver
enst
ENST00000380038
resolver
enst
ENST00000445352
resolver
enst
ENST00000554280
resolver
enst
ENST00000555836
resolver
enst
ENST00000557575
resolver
genesymbol
KLC1
resolver
genesymbol
KNS2
resolver
genesymbol_syn
KLC
resolver
genesymbol_syn
KNS2
resolver
hgnc
HGNC:6387
resolver
uniprot
A6NF62
resolver
uniprot
F8VTM4
resolver
uniprot
F8W6L3
resolver
uniprot
G3V2E7
resolver
uniprot
G3V3H3
resolver
uniprot
G3V5R9
resolver
uniprot
G5E9S8
resolver
uniprot
Q7RTM2
resolver
uniprot
Q7RTM3
resolver
uniprot
Q7RTM5
resolver
uniprot
Q7RTP9
resolver
uniprot
Q7RTQ2
resolver
uniprot
Q7RTQ3
resolver
uniprot
Q7RTQ5
resolver
uniprot
Q7RTQ6
resolver
uniprot
Q86SF5
resolver
uniprot
Q86TF5
resolver
uniprot
Q86V74
resolver
uniprot
Q86V75
resolver
uniprot
Q86V76
resolver
uniprot
Q86V77
resolver
uniprot
Q86V78
resolver
uniprot
Q86V79
resolver
uniprot
Q96H62
resolver
uniprot_entry
F8W6L3_HUMAN
resolver
uniprot_entry
G3V2E7_HUMAN
resolver
uniprot_entry
G3V3H3_HUMAN
resolver
uniprot_entry
G3V5R9_HUMAN
resolver
uniprot_entry
G5E9S8_HUMAN
resolver
uniprot_entry
KLC1_HUMAN
resolver
uniprot_entry
Q7RTQ2_HUMAN
resolver
uniprot_sec
A6NF62
resolver
uniprot_sec
F8VTM4
resolver
uniprot_sec
Q7RTM2
resolver
uniprot_sec
Q7RTM3
resolver
uniprot_sec
Q7RTM5
resolver
uniprot_sec
Q7RTP9
resolver
uniprot_sec
Q7RTQ3
resolver
uniprot_sec
Q7RTQ5
resolver
uniprot_sec
Q7RTQ6
resolver
uniprot_sec
Q86SF5
resolver
uniprot_sec
Q86TF5
resolver
uniprot_sec
Q86V74
resolver
uniprot_sec
Q86V75
resolver
uniprot_sec
Q86V76
resolver
uniprot_sec
Q86V77
resolver
uniprot_sec
Q86V78
resolver
uniprot_sec
Q86V79
resolver
uniprot_sec
Q96H62
resolver
amino_acid_sequence
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGGVSGRASFCGKRQQQQWPGRRHR
uniprot
proteins
function
FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:21385839). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250|UniProtKB:P37285, ECO:0000269|PubMed:21385839}.
uniprot
proteins
mass_dalton
65310
uniprot
proteins
mutagenesis
MUTAGEN 460; /note="S->A: Abolished phosphorylation, leading to increased interaction with CLSTN1."; /evidence="ECO:0000269|PubMed:21385839"; MUTAGEN 460; /note="S->D: Mimics CLSTN1, leading to decreased interaction with CLSTN1."; /evidence="ECO:0000269|PubMed:21385839"; MUTAGEN 521; /note="S->A,D: No effect on motor function; when associated with A/D-524."; /evidence="ECO:0000269|PubMed:20074060"; MUTAGEN 524; /note="S->A,D: No effect on motor function; when associated with A/D-521."; /evidence="ECO:0000269|PubMed:20074060
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-460 by ERK inhibits interaction with CLSTN1 and localization to cytoplasmic vesicles. {ECO:0000269|PubMed:21385839}.
uniprot
proteins
protein_family
Kinesin light chain family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12839500
uniprot
proteins
pubmed
14970196
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20074060
uniprot
proteins
pubmed
21385839
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21925109
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25898167
uniprot
proteins
pubmed
8274221
uniprot
proteins
sequence_length
573
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, growth cone {ECO:0000250|UniProtKB:P37285}. Cytoplasmic vesicle {ECO:0000269|PubMed:21385839}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:14970196}.
uniprot
proteins