Klhl24
entrez
303803
canonical
uniprot
Q56A24
canonical
ensembl
ENSRNOG00000033372
resolver
ensembl
ENSRNOG00055004730
resolver
ensembl
ENSRNOG00060011991
resolver
ensembl
ENSRNOG00065004385
resolver
ensp
ENSRNOP00000050815
resolver
ensp
ENSRNOP00055005640
resolver
ensp
ENSRNOP00060015987
resolver
ensp
ENSRNOP00065004501
resolver
enst
ENSRNOT00000052120
resolver
enst
ENSRNOT00055007517
resolver
enst
ENSRNOT00060020326
resolver
enst
ENSRNOT00065006381
resolver
genesymbol
Klhl24
resolver
genesymbol_syn
Dre1
resolver
uniprot
Q812D9
resolver
uniprot_entry
KLH24_RAT
resolver
uniprot_sec
Q812D9
resolver
amino_acid_sequence
MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEYFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKTFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCIGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAVYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL
uniprot
proteins
function
FUNCTION: Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (By similarity). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (By similarity). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (PubMed:17254796). Has a crucial role in cardiac development and function (By similarity). {ECO:0000250|UniProtKB:Q6TFL4, ECO:0000269|PubMed:17254796}.
uniprot
proteins
mass_dalton
68364
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. Autoubiquitination leads to proteasomal degradation and is necessary to control KLHL24 levels. {ECO:0000250|UniProtKB:Q6TFL4}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17254796
uniprot
proteins
sequence_length
600
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Perikaryon {ECO:0000269|PubMed:17254796}. Cell projection, axon {ECO:0000269|PubMed:17254796}. Cytoplasm {ECO:0000269|PubMed:17254796}. Cell junction, desmosome {ECO:0000250|UniProtKB:Q6TFL4}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q6TFL4}.
uniprot
proteins