PPP4R2
entrez
151987
canonical
uniprot
Q9NY27
canonical
ensembl
ENSG00000163605
resolver
ensp
ENSP00000349124
resolver
ensp
ENSP00000418675
resolver
enst
ENST00000495566
resolver
genesymbol
PPP4R2
resolver
hgnc
HGNC:18296
resolver
uniprot
A8K1I6
resolver
uniprot
C9IZF4
resolver
uniprot
Q2TAJ9
resolver
uniprot
Q498B8
resolver
uniprot
Q8WXX6
resolver
uniprot_entry
C9IZF4_HUMAN
resolver
uniprot_entry
PP4R2_HUMAN
resolver
uniprot_sec
A8K1I6
resolver
uniprot_sec
Q2TAJ9
resolver
uniprot_sec
Q498B8
resolver
uniprot_sec
Q8WXX6
resolver
amino_acid_sequence
MDVERLQEALKDFEKRGKKEVCPVLDQFLCHVAKTGETMIQWSQFKGYFIFKLEKVMDDFRTSAPEPRGPPNPNVEYIPFDEMKERILKIVTGFNGIPFTIQRLCELLTDPRRNYTGTDKFLRGVEKNVMVVSCVYPSSEKNNSNSLNRMNGVMFPGNSPSYTERSNINGPGTPRPLNRPKVSLSAPMTTNGLPESTDSKEANLQQNEEKNHSDSSTSESEVSSVSPLKNKHPDEDAVEAEGHEVKRLRFDKEGEVRETASQTTSSEISSVMVGETEASSSSQDKDKDSRCTRQHCTEEDEEEDEEEEEESFMTSREMIPERKNQEKESDDALTVNEETSEENNQMEESDVSQAEKDLLHSEGSENEGPVSSSSSDCRETEELVGSNSSKTGEILSESSMENDDEATEVTDEPMEQD
uniprot
proteins
function
FUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}.
uniprot
proteins
mass_dalton
46898
uniprot
proteins
mutagenesis
MUTAGEN 99; /note="F->A: No effect on RPA2-binding; decrease in PPP4C-binding."; /evidence="ECO:0000269|PubMed:20154705"; MUTAGEN 103; /note="R->A: No effect on RPA2-binding; loss of PPP4C-binding."; /evidence="ECO:0000269|PubMed:20154705"; MUTAGEN 106; /note="E->A: No effect on RPA2-binding, nor on PPP4C-binding."; /evidence="ECO:0000269|PubMed:20154705
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF(FBXO42) complex; leading to proteasomal degradation. {ECO:0000269|PubMed:41484364}.
uniprot
proteins
protein_family
PPP4R2 family
uniprot
proteins
pubmed
10769191
uniprot
proteins
pubmed
12668731
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18614045
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20154705
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
41484364
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2.
uniprot
proteins