Abcd2
entrez
84356
canonical
uniprot
Q9QY44
canonical
ensembl
ENSRNOG00000015538
resolver
ensembl
ENSRNOG00055012251
resolver
ensembl
ENSRNOG00060008304
resolver
ensembl
ENSRNOG00065018844
resolver
ensp
ENSRNOP00000021064
resolver
ensp
ENSRNOP00055016820
resolver
ensp
ENSRNOP00060010508
resolver
ensp
ENSRNOP00065025239
resolver
enst
ENSRNOT00000021064
resolver
enst
ENSRNOT00055020842
resolver
enst
ENSRNOT00060013786
resolver
enst
ENSRNOT00065031650
resolver
genesymbol
Abcd2
resolver
genesymbol_syn
Aldr
resolver
genesymbol_syn
Aldrp
resolver
uniprot
G3V7Z6
resolver
uniprot_entry
ABCD2_RAT
resolver
uniprot_sec
G3V7Z6
resolver
amino_acid_sequence
MIHMLNAAAYRVKWTRSGAAKRAACLVAAAYALKTLYPILGRRLKQPGHRKAKAEDYPPAENRERLHCTEIICKKPAPGLNADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKPRTFIIKLVKWLMIAVPATFVNSAIRYLECKLALAFRTRLVDHAYETYFANQTYYKVINMDGRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVILTSYTLIRTATSRGASPIGPTLLAGLVVYATAKVLKACSPKFGTLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQKCYKALAYQMNLILSKRLWYIMIEQFLMKYVWSGCGLIMVAIPIITATGFADGDLEDGPKQAMVSDRTEAFTTARNLLASGADAIERIMSSYKEITELAGYTARVYNMFWVFDEVKRGIYKRTVTQEPENNSKSRGGLELPLSDTLAIKGTVIDVDHGILCENVPIITPAGEVVASSLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHEKGYTDRDLEHILHSVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAIGAGISLLSITHRPSLWKYHTHLLQFDGEGGWRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQQRLNELCKILGEDSVLKTIQTAEDTS
uniprot
proteins
ec_number
3.1.2.-
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (By similarity). Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transported in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (By similarity). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro) (PubMed:21209459). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:21209459). However,the actual function of ABCD2 in vivo is still unclear (By similarity). {ECO:0000250|UniProtKB:P33897, ECO:0000250|UniProtKB:Q9UBJ2, ECO:0000269|PubMed:21209459}.
uniprot
proteins
mass_dalton
83468
uniprot
proteins
mutagenesis
MUTAGEN 207; /note="D->H: Does not affect ABCD1 interaction."; /evidence="ECO:0000269|PubMed:21209459
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCD family
uniprot
proteins
protein_family
Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily
uniprot
proteins
pubmed
11342107
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
21209459
uniprot
proteins
pubmed
28258215
uniprot
proteins
sequence_length
741
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:28258215}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 107..127; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 144..164; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 251..271; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 351..371; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins