FBXL15
entrez
79176
canonical
uniprot
Q9H469
canonical
ensembl
ENSG00000107872
resolver
ensp
ENSP00000358972
resolver
ensp
ENSP00000534408
resolver
ensp
ENSP00000534409
resolver
ensp
ENSP00000603268
resolver
ensp
ENSP00000618475
resolver
ensp
ENSP00000618476
resolver
ensp
ENSP00000618477
resolver
enst
ENST00000369956
resolver
enst
ENST00000864349
resolver
enst
ENST00000864350
resolver
enst
ENST00000933209
resolver
enst
ENST00000948416
resolver
enst
ENST00000948417
resolver
enst
ENST00000948418
resolver
genesymbol
FBXL15
resolver
genesymbol_syn
FBXO37
resolver
hgnc
HGNC:28155
resolver
uniprot
A1L4J8
resolver
uniprot
B1AKX8
resolver
uniprot
B1AKX9
resolver
uniprot
B1AKY0
resolver
uniprot
B1AKY1
resolver
uniprot
C9JWA4
resolver
uniprot
Q0D2Q3
resolver
uniprot
Q49AL7
resolver
uniprot
Q5JWA5
resolver
uniprot_entry
FXL15_HUMAN
resolver
uniprot_sec
A1L4J8
resolver
uniprot_sec
B1AKX8
resolver
uniprot_sec
B1AKX9
resolver
uniprot_sec
B1AKY0
resolver
uniprot_sec
B1AKY1
resolver
uniprot_sec
C9JWA4
resolver
uniprot_sec
Q0D2Q3
resolver
uniprot_sec
Q49AL7
resolver
uniprot_sec
Q5JWA5
resolver
amino_acid_sequence
MEPPMEPSGGEQEPGAVRFLDLPWEDVLLPHVLNRVPLRQLLRLQRVSRAFRSLVQLHLAGLRRFDAAQVGPQIPRAALARLLRDAEGLQELALAPCHEWLSDEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDAAVQELARNCPELHHLDLTGCLRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESSLSRLRKRGVDIDVEPPLHQALVLLQDMAGFAPFVNLQV
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2. {ECO:0000269|PubMed:21572392}.
uniprot
proteins
mass_dalton
32998
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
FBXL15 family
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21572392
uniprot
proteins
pubmed
22814378
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21572392}.
uniprot
proteins