Bcat2
entrez
64203
canonical
uniprot
O35854
canonical
ensembl
ENSRNOG00000020956
resolver
ensp
ENSRNOP00000028474
resolver
ensp
ENSRNOP00000095006
resolver
enst
ENSRNOT00000028474
resolver
genesymbol
Bcat2
resolver
genesymbol_syn
Bcatm
resolver
genesymbol_syn
Eca40
resolver
uniprot
G3V8U8
resolver
uniprot_entry
BCAT2_RAT
resolver
uniprot_entry
G3V8U8_RAT
resolver
amino_acid_sequence
MSAAILGQVWTRKLLPIPWRLCVPGRCVSSNFKAADLQVQVTREPQKKPAPSQPLLFGKTFTDHMLMVEWNSKTGWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGRDKQVRLFRPWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEVDKDWVPDGNGTSLYVRPVLIGNEPSLGVGMVTQALLFVILCPVGSYFPGDSMTPVSLLADPSFVRAWIGGVGDCKLGGNYGPTVAVQQEAQKKGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGELELATPPLDGIILPGVVRQSLLDLARTWGEFRVAERKVTMKELKRALEEGRVREVFGSGTACQVCPVHQILYEGKQLHIPTMENGPELILRFQKELKAIQYGTSAHDWMLRV
uniprot
proteins
ec_number
2.6.1.42
uniprot
proteins
function
FUNCTION: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine (PubMed:8381418, PubMed:9165094). Branched chain amino acid catabolism plays a role in adipocyte differentiation by providing lipogenic acetyl-CoA pools in differentiated adipocytes (By similarity). Mechanistically, acetyl-CoA derived from branched chain amino acid catabolism is used by EP300/p300 to acetylate and inhibit PRDM16, thereby preventing adipose tissue browning (By similarity). May also function as a transporter of branched chain alpha-keto acids (PubMed:8428987). {ECO:0000250|UniProtKB:O35855, ECO:0000269|PubMed:8381418, ECO:0000269|PubMed:8428987, ECO:0000269|PubMed:9165094}.
uniprot
proteins
mass_dalton
44276
uniprot
proteins
protein_family
Class-IV pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8381418
uniprot
proteins
pubmed
8428987
uniprot
proteins
pubmed
9165094
uniprot
proteins
sequence_length
393
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:8381418, ECO:0000269|PubMed:9165094}.
uniprot
proteins