Bmpr1b
entrez
12167
canonical
uniprot
P36898
canonical
ensembl
ENSMUSG00000052430
resolver
ensp
ENSMUSP00000029948
resolver
ensp
ENSMUSP00000096167
resolver
ensp
ENSMUSP00000101837
resolver
ensp
ENSMUSP00000101839
resolver
ensp
ENSMUSP00000230746
resolver
ensp
ENSMUSP00000230747
resolver
ensp
ENSMUSP00000230748
resolver
ensp
ENSMUSP00000230757
resolver
enst
ENSMUST00000029948
resolver
enst
ENSMUST00000098568
resolver
enst
ENSMUST00000106230
resolver
enst
ENSMUST00000106232
resolver
genesymbol
Bmpr1b
resolver
genesymbol_syn
Acvrlk6
resolver
uniprot
B2RRZ4
resolver
uniprot
Q3TRF2
resolver
uniprot
Q3USS1
resolver
uniprot_entry
B2RRZ4_MOUSE
resolver
uniprot_entry
BMR1B_MOUSE
resolver
uniprot_entry
Q3USS1_MOUSE
resolver
uniprot_sec
Q3TRF2
resolver
amino_acid_sequence
MLLRSSGKLNVGTKKEDGESTAPTPRPKILRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGMPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKDRDFVDGPIHHKALLISVTVCSLLLVLIILFCYFRYKRQEARPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEIARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCMKKLRPSFPNRWSSDECLRQMGKLMTECWAQNPASRLTALRVKKTLAKMSESQDIKL
uniprot
proteins
ec_number
2.7.11.30
uniprot
proteins
function
FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1. Receptor for GDF5 (PubMed:19229295, PubMed:26105076). Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149). {ECO:0000269|PubMed:19229295, ECO:0000269|PubMed:24098149, ECO:0000269|PubMed:26105076}.
uniprot
proteins
mass_dalton
56944
uniprot
proteins
mutagenesis
MUTAGEN 200; /note="I->K: Loss of kinase activity. No effect on cell membrane location."; /evidence="ECO:0000269|PubMed:14523231"; MUTAGEN 486; /note="R->W: No effect on kinase activity. No effect on cell membrane location."; /evidence="ECO:0000269|PubMed:14523231
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000269|PubMed:14523231}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TGFB receptor subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
14523231
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19229295
uniprot
proteins
pubmed
24098149
uniprot
proteins
pubmed
24129431
uniprot
proteins
pubmed
26105076
uniprot
proteins
pubmed
8140412
uniprot
proteins
sequence_length
502
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14523231, ECO:0000269|PubMed:24129431, ECO:0000269|PubMed:26105076}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 127..148; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins