Ppard
entrez
19015
canonical
uniprot
P35396
canonical
ensembl
ENSMUSG00000002250
resolver
ensp
ENSMUSP00000002320
resolver
ensp
ENSMUSP00000156879
resolver
enst
ENSMUST00000002320
resolver
genesymbol
Ppard
resolver
genesymbol_syn
Nr1c2
resolver
genesymbol_syn
PPARb/d
resolver
genesymbol_syn
Pparb
resolver
uniprot
P37239
resolver
uniprot
Q546I3
resolver
uniprot_entry
PPARD_MOUSE
resolver
uniprot_entry
Q546I3_MOUSE
resolver
uniprot_sec
P37239
resolver
amino_acid_sequence
MEQPQEETPEAREEEKEEVAMGDGAPELNGGPEHTLPSSSCADLSQNSSPSSLLDQLQMGCDGASGGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCDRICKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTASEGCQHNPQLADLKAFSKHIYNAYLKNFNMTKKKARSILTGKSSHNAPFVIHDIETLWQAEKGLVWKQLVNGLPPYNEISVHVFYRCQSTTVETVRELTEFAKNIPNFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTHEFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPQVEAIQDTILRALEFHLQVNHPDSQYLFPKLLQKMADLRQLVTEHAQMMQWLKKTESETLLHPLLQEIYKDMY
uniprot
proteins
function
FUNCTION: Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues (PubMed:35675826). Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity). {ECO:0000250|UniProtKB:Q03181, ECO:0000269|PubMed:35675826}.
uniprot
proteins
mass_dalton
49715
uniprot
proteins
post_translational_modification
PTM: 'Lys-48'-linked polyubiquitinated; leading to proteasomal degradation. Deubiquitinated and stabilized by OTUD3. {ECO:0000269|PubMed:35675826}.
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28683290
uniprot
proteins
pubmed
28751364
uniprot
proteins
pubmed
35675826
uniprot
proteins
pubmed
7836471
uniprot
proteins
pubmed
8041794
uniprot
proteins
pubmed
8240342
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35675826}.
uniprot
proteins