GAREM1
entrez
64762
canonical
uniprot
Q9H706
canonical
ensembl
ENSG00000141441
resolver
ensp
ENSP00000269209
resolver
ensp
ENSP00000382165
resolver
genesymbol
GAREM1
resolver
genesymbol_syn
C18orf11
resolver
genesymbol_syn
FAM59A
resolver
genesymbol_syn
GAREM
resolver
hgnc
HGNC:26136
resolver
uniprot
Q0VAG3
resolver
uniprot
Q0VAG4
resolver
uniprot
Q8ND03
resolver
uniprot
Q9BSF5
resolver
uniprot_entry
GARE1_HUMAN
resolver
uniprot_sec
Q0VAG3
resolver
uniprot_sec
Q0VAG4
resolver
uniprot_sec
Q8ND03
resolver
uniprot_sec
Q9BSF5
resolver
amino_acid_sequence
MDPAPSLGCSLKDVKWSSVAVPLDLLVSTYRLPQIARLDNGECVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGQFKLLEQDRDIKEPVQYFNSVEEVAKAFPERVYVMEDITFNVKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSISKLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQTKTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKSPKKGRCSGHNHVPNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIPGKSELPYEELWLEEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPSIPPRTVKPARQQTRSPSPTLSYYSSGLHNISVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWPNHYSGASESQTRSDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTKQSTSCPALPPRAPKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSKSLRFIGLSEDVISFFVTEKIDGNLLVQLTEEILSEDFKLSKLQVKKIMQFINGWRPKI
uniprot
proteins
function
FUNCTION: [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}.
uniprot
proteins
mass_dalton
97186
uniprot
proteins
mutagenesis
MUTAGEN 105; /note="Y->F: Does not abolish phosphorylation upon EGF stimulation. Reduces interaction with GRB2. Abolishes phosphorylation, interaction with GRB2 and ERK activation upon EGF stimulation; when associated with F-453."; /evidence="ECO:0000269|PubMed:19509291"; MUTAGEN 453; /note="Y->F: Does not abolish phosphorylation upon EGF stimulation. Abolishes interaction with PTPN11. Abolishes phosphorylation upon EGF stimulation; when associated with F-105."; /evidence="ECO:0000269|PubMed:19509291
uniprot
proteins
post_translational_modification
PTM: On EGF stimulation, phosphorylated on Tyr-105 and Tyr-453. {ECO:0000269|PubMed:19509291}.
uniprot
proteins
protein_family
GAREM family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19509291
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
876
uniprot
proteins