MAPK7
entrez
5598
canonical
uniprot
Q13164
canonical
ensembl
ENSG00000166484
resolver
ensp
ENSP00000299612
resolver
ensp
ENSP00000311005
resolver
ensp
ENSP00000378966
resolver
ensp
ENSP00000378968
resolver
ensp
ENSP00000555461
resolver
ensp
ENSP00000555464
resolver
ensp
ENSP00000555465
resolver
genesymbol
MAPK7
resolver
genesymbol_syn
BMK1
resolver
genesymbol_syn
ERK5
resolver
genesymbol_syn
PRKM7
resolver
hgnc
HGNC:6880
resolver
uniprot
Q16634
resolver
uniprot
Q59F50
resolver
uniprot
Q6QLU7
resolver
uniprot
Q7L4P4
resolver
uniprot
Q969G1
resolver
uniprot
Q96G51
resolver
uniprot_entry
MK07_HUMAN
resolver
uniprot_sec
Q16634
resolver
uniprot_sec
Q59F50
resolver
uniprot_sec
Q6QLU7
resolver
uniprot_sec
Q7L4P4
resolver
uniprot_sec
Q969G1
resolver
uniprot_sec
Q96G51
resolver
activity_regulation
ACTIVITY REGULATION: Activated by tyrosine and threonine phosphorylation (By similarity). Activated in response to hyperosmolarity, hydrogen peroxide, and epidermal growth factor (EGF). {ECO:0000250, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}.
uniprot
proteins
amino_acid_sequence
MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
uniprot
proteins
ec_number
2.7.11.24
uniprot
proteins
function
FUNCTION: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}.
uniprot
proteins
mass_dalton
88386
uniprot
proteins
mutagenesis
MUTAGEN 219..221; /note="TEY->AEF: Loss activation by MAP2K5."; /evidence="ECO:0000269|PubMed:9384584
uniprot
proteins
post_translational_modification
PTM: Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme (By similarity). Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent. {ECO:0000250, ECO:0000269|PubMed:22869143}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MAP kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11254654
uniprot
proteins
pubmed
11278431
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15716121
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20724525
uniprot
proteins
pubmed
22869143
uniprot
proteins
pubmed
23428871
uniprot
proteins
pubmed
7646528
uniprot
proteins
pubmed
7759517
uniprot
proteins
pubmed
9384584
uniprot
proteins
pubmed
9790194
uniprot
proteins
sequence_length
816
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, PML body. Note=Translocates to the nucleus upon activation.
uniprot
proteins