CALHM2
entrez
51063
canonical
uniprot
Q9HA72
canonical
ensembl
ENSG00000138172
resolver
ensp
ENSP00000260743
resolver
ensp
ENSP00000552066
resolver
ensp
ENSP00000552067
resolver
ensp
ENSP00000552068
resolver
ensp
ENSP00000552069
resolver
ensp
ENSP00000552070
resolver
ensp
ENSP00000552071
resolver
ensp
ENSP00000552072
resolver
ensp
ENSP00000552073
resolver
ensp
ENSP00000634458
resolver
ensp
ENSP00000634461
resolver
ensp
ENSP00000658476
resolver
ensp
ENSP00000658478
resolver
ensp
ENSP00000658479
resolver
ensp
ENSP00000703229
resolver
ensp
ENSP00000703230
resolver
ensp
ENSP00000703231
resolver
ensp
ENSP00000703232
resolver
ensp
ENSP00000703235
resolver
ensp
ENSP00000703236
resolver
ensp
ENSP00000794771
resolver
genesymbol
CALHM2
resolver
genesymbol_syn
FAM26B
resolver
hgnc
HGNC:23493
resolver
uniprot
D3DR94
resolver
uniprot
O95893
resolver
uniprot
Q6ZUV9
resolver
uniprot_entry
CAHM2_HUMAN
resolver
uniprot_sec
D3DR94
resolver
uniprot_sec
O95893
resolver
uniprot_sec
Q6ZUV9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Ca(2+) and ruthenium red in a voltage-dependent way. {ECO:0000269|PubMed:31776515, ECO:0000269|PubMed:32832629}.
uniprot
proteins
amino_acid_sequence
MAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPS
uniprot
proteins
function
FUNCTION: Pore-forming subunit of Ca(2+) homeostasis modulator channels. Mediates ATP release from astrocytes and ATP-induced Ca(2+) influx in microglia thus regulating neuronal ATP and Ca(2+) homeostasis, synaptic transmission and neuroinflammatory response. May form intercellular gap junctions. The gating mechanism remains unknown. {ECO:0000250|UniProtKB:Q8VEC4, ECO:0000269|PubMed:31776515, ECO:0000269|PubMed:32832629}.
uniprot
proteins
mass_dalton
36175
uniprot
proteins
mutagenesis
MUTAGEN 1..52; /note="Missing: Does not affect intrasubunit interactions."; /evidence="ECO:0000269|PubMed:31776515"; MUTAGEN 1..20; /note="Missing: Markedly reduces the inhibition by ruthenium red. Does not affect Ca(2+)-dependent inactivation of the channel."; /evidence="ECO:0000269|PubMed:31776515"; MUTAGEN 10; /note="R->A: Markedly reduces the inhibition by ruthenium red at negative membrane potentials. Does not affect Ca(2+)-dependent inactivation of the channel."; /evidence="ECO:0000269|PubMed:31776515"; MUTAGEN 37; /note="E->R: Reduces the inhibition by ruthenium red."; /evidence="ECO:0000269|PubMed:31776515"; MUTAGEN 143..146; /note="Missing: Prevents gap junction formation."; /evidence="ECO:0000269|PubMed:31776515"; MUTAGEN 238; /note="H->A: Decreases intrasubunit interactions."; /evidence="ECO:0000269|PubMed:31776515"; MUTAGEN 251; /note="F->A: Decreases intrasubunit interactions."; /evidence="ECO:0000269|PubMed:31776515
uniprot
proteins
protein_family
CALHM family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18585350
uniprot
proteins
pubmed
31776515
uniprot
proteins
pubmed
31988524
uniprot
proteins
pubmed
32374262
uniprot
proteins
pubmed
32832629
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8VEC4}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..43; /note="Helical; Name=S1"; /evidence="ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV"; TRANSMEM 53..76; /note="Helical; Name=S2"; /evidence="ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV"; TRANSMEM 102..132; /note="Helical; Name=S3"; /evidence="ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV"; TRANSMEM 180..206; /note="Helical; Name=S4"; /evidence="ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV
uniprot
proteins