SUN2
entrez
25777
canonical
uniprot
Q9UH99
canonical
ensembl
ENSG00000100242
resolver
ensp
ENSP00000385616
resolver
ensp
ENSP00000385740
resolver
ensp
ENSP00000390154
resolver
ensp
ENSP00000415588
resolver
ensp
ENSP00000508608
resolver
ensp
ENSP00000540890
resolver
ensp
ENSP00000540891
resolver
ensp
ENSP00000540893
resolver
ensp
ENSP00000540895
resolver
ensp
ENSP00000540897
resolver
ensp
ENSP00000540898
resolver
ensp
ENSP00000540902
resolver
ensp
ENSP00000540904
resolver
ensp
ENSP00000540912
resolver
ensp
ENSP00000540914
resolver
ensp
ENSP00000589921
resolver
ensp
ENSP00000626791
resolver
ensp
ENSP00000626795
resolver
ensp
ENSP00000626796
resolver
ensp
ENSP00000626798
resolver
ensp
ENSP00000678272
resolver
enst
ENST00000455125
resolver
enst
ENST00000456894
resolver
enst
ENST00000870832
resolver
enst
ENST00000870853
resolver
genesymbol
SUN2
resolver
genesymbol_syn
FRIGG
resolver
genesymbol_syn
KIAA0668
resolver
genesymbol_syn
RAB5IP
resolver
genesymbol_syn
UNC84B
resolver
hgnc
HGNC:14210
resolver
uniprot
B0QY60
resolver
uniprot
B0QY62
resolver
uniprot
B0QY64
resolver
uniprot
B4E2A6
resolver
uniprot
O75156
resolver
uniprot
Q2NKN8
resolver
uniprot
Q2T9F7
resolver
uniprot
Q504T5
resolver
uniprot
Q6B4H1
resolver
uniprot
Q7Z3E3
resolver
uniprot_entry
B0QY60_HUMAN
resolver
uniprot_entry
B0QY64_HUMAN
resolver
uniprot_entry
B4E2A6_HUMAN
resolver
uniprot_entry
SUN2_HUMAN
resolver
uniprot_sec
B0QY62
resolver
uniprot_sec
O75156
resolver
uniprot_sec
Q2NKN8
resolver
uniprot_sec
Q2T9F7
resolver
uniprot_sec
Q504T5
resolver
uniprot_sec
Q6B4H1
resolver
uniprot_sec
Q7Z3E3
resolver
amino_acid_sequence
MSRRSQRLTRYSQGDDDGSSSSGGSSVAGSQSTLFKDSPLRTLKRKSSNMKRLSPAPQLGPSSDAHTSYYSESLVHESWFPPRSSLEELHGDANWGEDLRVRRRRGTGGSESSRASGLVGRKATEDFLGSSSGYSSEDDYVGYSDVDQQSSSSRLRSAVSRAGSLLWMVATSPGRLFRLLYWWAGTTWYRLTTAASLLDVFVLTRRFSSLKTFLWFLLPLLLLTCLTYGAWYFYPYGLQTFHPALVSWWAAKDSRRPDEGWEARDSSPHFQAEQRVMSRVHSLERRLEALAAEFSSNWQKEAMRLERLELRQGAPGQGGGGGLSHEDTLALLEGLVSRREAALKEDFRRETAARIQEELSALRAEHQQDSEDLFKKIVRASQESEARIQQLKSEWQSMTQESFQESSVKELRRLEDQLAGLQQELAALALKQSSVAEEVGLLPQQIQAVRDDVESQFPAWISQFLARGGGGRVGLLQREEMQAQLRELESKILTHVAEMQGKSAREAAASLSLTLQKEGVIGVTEEQVHHIVKQALQRYSEDRIGLADYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGKFTYDQDGEPIQTFHFQAPTMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH
uniprot
proteins
function
FUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}.
uniprot
proteins
mass_dalton
80311
uniprot
proteins
mutagenesis
MUTAGEN 536; /note="L->D: Disrupts interaction with SYNE2."; /evidence="ECO:0000269|PubMed:22632968"; MUTAGEN 538; /note="Missing: Disrupts interaction with SYNE2."; /evidence="ECO:0000269|PubMed:22632968"; MUTAGEN 542; /note="D->N: Disrupts interaction with SYNE2."; /evidence="ECO:0000269|PubMed:22170055, ECO:0000269|PubMed:22632968"; MUTAGEN 563; /note="C->A: Decreases stability of the SUN2:SYNE2/KASH2 complex under tensile forces and inhibits force transmission through the complex."; /evidence="ECO:0000269|PubMed:26244732"; MUTAGEN 603; /note="A->E: Decreases interaction with SYNE2. Disrupts interaction with SYNE2; when associated with E-641 and E-703."; /evidence="ECO:0000269|PubMed:22945352"; MUTAGEN 609; /note="G->D: Decreases interaction with SYNE2."; /evidence="ECO:0000269|PubMed:22170055"; MUTAGEN 628; /note="H->A: Disrupts interaction with SYNE2."; /evidence="ECO:0000269|PubMed:22632968"; MUTAGEN 641; /note="S->E: Decreases interaction with SYNE2. Disrupts interaction with SYNE2; when associated with E-603 and E-703."; /evidence="ECO:0000269|PubMed:22632968, ECO:0000269|PubMed:22945352"; MUTAGEN 703; /note="Y->E: Decreases interaction with SYNE2. Disrupts interaction with SYNE2; when associated with E-603 and E-641."; /evidence="ECO:0000269|PubMed:22945352"; MUTAGEN 707; /note="Y->F: Disrupts interaction with SYNE2, impairs localization to the nuclear envelope."; /evidence="ECO:0000269|PubMed:22632968
uniprot
proteins
post_translational_modification
PTM: The disulfide bond with SYNE2 is required for stability of the SUN2:SYNE2/KASH2 LINC complex under tensile forces though not required for the interaction. The disulfide bond is proposed to be conserved in LINC complexes involved in force transmission. {ECO:0000269|PubMed:26244732}.
uniprot
proteins
pubmed
10375507
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10818110
uniprot
proteins
pubmed
12239280
uniprot
proteins
pubmed
12393179
uniprot
proteins
pubmed
12958361
uniprot
proteins
pubmed
15082709
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17132086
uniprot
proteins
pubmed
17724119
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18396275
uniprot
proteins
pubmed
18845190
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21391237
uniprot
proteins
pubmed
22170055
uniprot
proteins
pubmed
22632968
uniprot
proteins
pubmed
22945352
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26244732
uniprot
proteins
pubmed
35311970
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
717
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:15082709}; Single-pass type II membrane protein {ECO:0000269|PubMed:15082709}. Nucleus envelope {ECO:0000269|PubMed:15082709, ECO:0000269|PubMed:17132086, ECO:0000269|PubMed:17724119}. Endosome membrane {ECO:0000269|PubMed:10818110}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 213..233; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins