DDX18
entrez
8886
canonical
uniprot
Q9NVP1
canonical
ensembl
ENSG00000088205
resolver
ensp
ENSP00000263239
resolver
enst
ENST00000263239
resolver
genesymbol
DDX18
resolver
genesymbol_syn
cPERP-D
resolver
hgnc
HGNC:2741
resolver
uniprot
Q6GTZ9
resolver
uniprot
Q6IAU4
resolver
uniprot
Q8N254
resolver
uniprot
Q92732
resolver
uniprot
Q9BQB7
resolver
uniprot_entry
DDX18_HUMAN
resolver
uniprot_entry
Q8N254_HUMAN
resolver
uniprot_sec
Q6GTZ9
resolver
uniprot_sec
Q6IAU4
resolver
uniprot_sec
Q92732
resolver
uniprot_sec
Q9BQB7
resolver
amino_acid_sequence
MSHLPMKLLRKKIEKRNLKLRQRNLKFQGASNLTLSETQNGDVSEETMGSRKVKKSKQKPMNVGLSETQNGGMSQEAVGNIKVTKSPQKSTVLTNGEAAMQSSNSESKKKKKKKRKMVNDAEPDTKKAKTENKGKSEEESAETTKETENNVEKPDNDEDESEVPSLPLGLTGAFEDTSFASLCNLVNENTLKAIKEMGFTNMTEIQHKSIRPLLEGRDLLAAAKTGSGKTLAFLIPAVELIVKLRFMPRNGTGVLILSPTRELAMQTFGVLKELMTHHVHTYGLIMGGSNRSAEAQKLGNGINIIVATPGRLLDHMQNTPGFMYKNLQCLVIDEADRILDVGFEEELKQIIKLLPTRRQTMLFSATQTRKVEDLARISLKKEPLYVGVDDDKANATVDGLEQGYVVCPSEKRFLLLFTFLKKNRKKKLMVFFSSCMSVKYHYELLNYIDLPVLAIHGKQKQNKRTTTFFQFCNADSGTLLCTDVAARGLDIPEVDWIVQYDPPDDPKEYIHRVGRTARGLNGRGHALLILRPEELGFLRYLKQSKVPLSEFDFSWSKISDIQSQLEKLIEKNYFLHKSAQEAYKSYIRAYDSHSLKQIFNVNNLNLPQVALSFGFKVPPFVDLNVNSNEGKQKKRGGGGGFGYQKTKKVEKSKIFKHISKKSSDSRQFSH
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R-loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA-lesion-associated R-loop (PubMed:35858569). Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells. Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus (By similarity). {ECO:0000250|UniProtKB:Q8K363, ECO:0000269|PubMed:35858569}.
uniprot
proteins
mass_dalton
75407
uniprot
proteins
mutagenesis
MUTAGEN 518; /note="R->A: Decreased poly(ADP-ribose) (PAR) polymers-binding ability; when associated with A-523."; /evidence="ECO:0000269|PubMed:35858569"; MUTAGEN 523; /note="R->A: Decreased poly(ADP-ribose) (PAR) polymers-binding ability; when associated with A-518."; /evidence="ECO:0000269|PubMed:35858569
uniprot
proteins
protein_family
DDX18/HAS1 subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
16963496
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20813266
uniprot
proteins
pubmed
20941364
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
35858569
uniprot
proteins
pubmed
8861962
uniprot
proteins
sequence_length
670
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16963496}. Chromosome {ECO:0000269|PubMed:20813266, ECO:0000269|PubMed:35858569}.
uniprot
proteins