BAT5
entrez
7920
canonical
uniprot
O95870
canonical
ensembl
ENSG00000204427
resolver
ensembl
ENSG00000206403
resolver
ensembl
ENSG00000224552
resolver
ensembl
ENSG00000230475
resolver
ensembl
ENSG00000231488
resolver
ensembl
ENSG00000235676
resolver
ensembl
ENSG00000236063
resolver
ensp
ENSP00000379282
resolver
ensp
ENSP00000410347
resolver
genesymbol
ABHD16A
resolver
genesymbol
BAT5
resolver
genesymbol_syn
BAT5
resolver
genesymbol_syn
G5
resolver
genesymbol_syn
NG26
resolver
hgnc
HGNC:13921
resolver
uniprot
A2BEY3
resolver
uniprot
B3KNX9
resolver
uniprot
B7Z4R6
resolver
uniprot
Q5SRR1
resolver
uniprot
Q5SRR2
resolver
uniprot
Q8WYH0
resolver
uniprot
Q9NW33
resolver
uniprot_entry
ABHGA_HUMAN
resolver
uniprot_entry
B3KNX9_HUMAN
resolver
uniprot_sec
A2BEY3
resolver
uniprot_sec
B7Z4R6
resolver
uniprot_sec
Q5SRR1
resolver
uniprot_sec
Q5SRR2
resolver
uniprot_sec
Q8WYH0
resolver
uniprot_sec
Q9NW33
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by beta-lactone-based lipid inhibitors, such as beta-lactone palmostatin-B. {ECO:0000269|PubMed:25290914}.
uniprot
proteins
amino_acid_sequence
MAKLLSCVLGPRLYKIYRERDSERAPASVPETPTAVTAPHSSSWDTYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSSENKRQLANYNFDFRSWPVDFHWEEPSSRKESRGGPSRRGVALLRPEPLHRGTADTLLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIIIYAWSIGGFTATWAAMSYPDVSAMILDASFDDLVPLALKVMPDSWRGLVTRTVRQHLNLNNAEQLCRYQGPVLLIRRTKDEIITTTVPEDIMSNRGNDLLLKLLQHRYPRVMAEEGLRVVRQWLEASSQLEEASIYSRWEVEEDWCLSVLRSYQAEHGPDFPWSVGEDMSADGRRQLALFLARKHLHNFEATHCTPLPAQNFQMPWHL
uniprot
proteins
disease_involvement
DISEASE: Spastic paraplegia 86, autosomal recessive (SPG86) [MIM:619735]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG86 is an autosomal recessive form associated with impaired intellectual development, poor or absent speech, and behavioral abnormalities. Brain imaging shows thin corpus callosum and white matter abnormalities. Rare patients may have seizures. {ECO:0000269|PubMed:34489854, ECO:0000269|PubMed:34587489, ECO:0000269|PubMed:34866177}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
ec_number
3.1.1.23
uniprot
proteins
function
FUNCTION: Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (PubMed:25290914). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (PubMed:25290914). {ECO:0000250|UniProtKB:Q9Z1Q2, ECO:0000269|PubMed:25290914}.
uniprot
proteins
mass_dalton
63243
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
ABHD16 family
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25290914
uniprot
proteins
pubmed
34489854
uniprot
proteins
pubmed
34587489
uniprot
proteins
pubmed
34866177
uniprot
proteins
sequence_length
558
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9Z1Q2}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 60..80; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins