Taok3
entrez
304530
canonical
uniprot
Q53UA7
canonical
ensembl
ENSRNOG00000001138
resolver
ensembl
ENSRNOG00055001772
resolver
ensembl
ENSRNOG00060006900
resolver
ensembl
ENSRNOG00065005822
resolver
ensp
ENSRNOP00000001503
resolver
ensp
ENSRNOP00055002151
resolver
ensp
ENSRNOP00060008446
resolver
ensp
ENSRNOP00065006183
resolver
enst
ENSRNOT00000001503
resolver
enst
ENSRNOT00055002867
resolver
enst
ENSRNOT00060011316
resolver
enst
ENSRNOT00065008726
resolver
genesymbol
Taok3
resolver
genesymbol_syn
Arg357
resolver
genesymbol_syn
Jik
resolver
uniprot_entry
TAOK3_RAT
resolver
amino_acid_sequence
MRKGVLKDPEIAELFFKEDPEELFIDLHEIGHGSFGAVYFATNAHTNEVVAIKKMSYSGKQTHEKWQDILKEVRFLQQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHFHSLIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSREWTDSFRRFVDYCLHKIPQERPAAAELLRHDFIRRERPPRVLIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEEEEDSEQGSNLNREVDSLGSIHSIPSVSVSTGSRSSSVNSMQEVMDEGSPELVMMQEDEGTVNSSSSMVHKKDHVFVRDEAGHGDPRPEPRPTQSVQSRALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVATIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDRNCRCFKRKIMTKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKAILKTLKEEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKTLLERQERETETFDMESLRMGFGNLVTLDFPKEDYR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells. Phosphorylates PTPN6/SHP1 on 'Thr-396', leading to its polyubiquitination and subsequent proteasomal degradation. Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells. Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells. Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway. Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis. Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines. Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue. {ECO:0000250|UniProtKB:Q8BYC6, ECO:0000250|UniProtKB:Q9H2K8}.
uniprot
proteins
mass_dalton
105474
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated at Ser-324 and on Tyr residues during T cell activation. Phosphorylated by LRRK2. {ECO:0000250|UniProtKB:Q9H2K8}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
16092929
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
898
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H2K8}. Cell membrane {ECO:0000250|UniProtKB:Q9H2K8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H2K8}. Membrane raft {ECO:0000250|UniProtKB:Q9H2K8}. Lipid droplet {ECO:0000250|UniProtKB:Q9H2K8}. Note=Located primarily outside cell membrane rafts and remains outside upon canonical TCR ligation. A small pool is detectable in cell membrane rafts in resting conditions but relocates outside the rafts upon TCR signaling. Localizes to lipid droplets in hepatocytes. {ECO:0000250|UniProtKB:Q9H2K8}.
uniprot
proteins