CLIC3
entrez
9022
canonical
uniprot
O95833
canonical
ensembl
ENSG00000169583
resolver
ensp
ENSP00000419378
resolver
enst
ENST00000494426
resolver
genesymbol
CLIC3
resolver
hgnc
HGNC:2064
resolver
uniprot
Q5SPZ7
resolver
uniprot_entry
CLIC3_HUMAN
resolver
uniprot_sec
Q5SPZ7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by rapamycin, amphotericin B and IAA-94. {ECO:0000269|PubMed:37759794}.
uniprot
proteins
amino_acid_sequence
MAETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAPGSQLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPVPAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRESRRRFLDGDRLTLADCSLLPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPR
uniprot
proteins
ec_number
1.8.-.-
uniprot
proteins
function
FUNCTION: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:28198360, PubMed:37759794). Reduced in a glutathione-dependent way and secreted into the extracellular matrix where it activates TGM2 and promotes blood vessel growth during tissue remodeling as occurs in tumorigenesis. Can reduce specific cysteines in TGM2 and regulate cofactor binding (PubMed:28198360). Can insert into membranes and form outwardly rectifying chloride ion channels. May participate in cellular growth control. {ECO:0000269|PubMed:28198360, ECO:0000269|PubMed:32066374, ECO:0000269|PubMed:37759794, ECO:0000269|PubMed:9880541}.
uniprot
proteins
mass_dalton
26648
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="C->A: Decreases glutathione-dependent oxidoreductase activity toward TGM2."; /evidence="ECO:0000269|PubMed:28198360
uniprot
proteins
protein_family
Chloride channel CLIC family
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17027078
uniprot
proteins
pubmed
20146363
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28198360
uniprot
proteins
pubmed
32066374
uniprot
proteins
pubmed
37759794
uniprot
proteins
pubmed
9880541
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Membrane; Single-pass membrane protein. Cell membrane {ECO:0000269|PubMed:32066374}; Single-pass membrane protein. Cytoplasm. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:28198360}. Note=Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). Secreted into the extracellular matrix by activated fibroblasts. {ECO:0000250, ECO:0000269|PubMed:28198360}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..44; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins