Ankrd31
entrez
625662
canonical
uniprot
A0A140LI88
canonical
ensembl
ENSMUSG00000109561
resolver
ensp
ENSMUSP00000344812
resolver
ensp
ENSMUSP00000344813
resolver
genesymbol
Ankrd31
resolver
uniprot
A0A140LIB3
resolver
uniprot_entry
ANR31_MOUSE
resolver
uniprot_sec
A0A140LIB3
resolver
amino_acid_sequence
MENGAEASDCDSDETVIEGSVTENEPEDEELPWRRLLLNQDTTCRSEFCFHSGVDGMQKGIHSPEIQLGLKLRKDSQEQNNKNKLLLALSEDLVLQDPQDKTAQNQVLLQTTKEFPVFTVSFPHPEVSWSHQNTGGHEAENCENLPHSKKELRENSDSPEVSLLSGTSPVAPDLVALKERLTEPVKTLAVPNTLSEPGEEVTQTMTSKETKDEESSLETFVSTLEKLLESSECTQEERLLEVMDDFNPQELFSTLSNSLGSVSVPLNAWAAQGRDELENKADAALPAKLLAAVNTGADVGPSCQGQEKSSSVSGGNGCLAVQPIMSQVDEDCTQIAQNIEDPKPFRLQTLTHENAISYEQINKKKNSDPIKNTSTQETPRVLRRSSRLEKLKASRDVVHTEAVLKKPERILSNTLSFKDQINSIFTTDSFSKRKNMHSSGFKNEQIRKSEQLRKKNGTGEMKKMCLCTINRRNVFGENLLYKAALHNDVDLVRCCIKNGENVNQPSYDGWTALHEASIGGYYQAVSELLKGGADVNVKGKYQITPLHDAVMNRHYKVAELLLMSGADPLFRSDHGTCALDEAKDSSMETLLMKYIPQQKKCHLSAQRNSTDPAHVEDMFQNKKPKLSSNNYTEFICDENFDRQEPGHLEINKGSNNLLMSKEYVCEHCQKDSNTTKFGKSNLNSVKNSRTNVSKRKGQKNRQQKKTQVDDRDCNLSQKIGTSSFRRTNKLLTQQQHAVQTLSDLPEESFELSTTTLSSLENGIGYNEACLVSKKSDTHVLDSSDGQELESVDQTEAASVSELSSYKEIKLLPVTTHQQPHTNQEQYSSPYKSLGNNSSNEKGKATNKWEDSFFSFIKGRSADSDSDCHTLDKSIASPKEGMSHDHHEEIMTGQEVDSQQRLSSENYFSQENDLKVHPLTTHPQEEAVNFCDSNLISVQHTPDYKNCLHEISFGNSYAKTEQSSTSCTRPPSTQKVSPLTVEVELLKGLQDSLAHRDSSPLVNQAGIHSLERKQDTDKNYTKKGPNTSSSSRPLPTVVHSQVIEITKAEKRREDLPGNEPINNTDFYSTDINKELANSSQLNQRKEKENVRKSDAELTHNDSEAERTLKSCEEKKKNMDSETHSPCDIQEHRKDQNFRKRKCSLKAPCSQGVNTTGIGKRNKKGESQLHVAARGGNLSRVKVLIEARADVNLRDNAGWTPLHKAASGGFDDVIIELLQAGANVNCENIDGIVPLHGASAGNHLKAAEILLEHGANPNQKDQKQRTALDEADDEKMKELLKSYGAIESTNGEKRNSTDLVKIPTVQPKRYKQFICDNDKAIGSPVPSHKAKKSESLPVHQTISAILQDIEEKQENLLKLEIRNSEDEEQYIGKMLEIKEVMDNILAQQKTERDDLAKKYRVSMESFKHGALREQLANLATRQKSLLVVAKKQKKIRLKIQNYKNATAVSGVGLRKLPCNSDISSDKKSQEPPTMGDSAHAQPGLLAPVSLAYGSMQEIPLSPEIESESQKINICLNAEAIRREEFSGNDINSKQNVQDCTLGGLLRSKPTDDAEKIASSSQPAALTPHAENSQAEATVKGCGFDSSALTGTINISEDKSIFSPNGACLAADPHSQKLSRCNPKRRNKKTASQQPSAGAAEPLPQAPAVLDTYTVHQTLPCLRDSAAAASHTDSTQSSLSSASAHQHPTKTVPHRNTTPRKKAVQLKDLILRGRINPGNNILEFKTQETTHRASVLPSGKLKGENGQIYQNPVTWLKELLGGGSYVTWNYAWNTVTYLGRELVKCVSEEAPMSAELNPPQLHQPHLSAGTSRESMQTIPHYLQIKEILQISKQELLPCHVMEQHWKFYVGRSHSEALLSW
uniprot
proteins
function
FUNCTION: Required for DNA double-strand breaks (DSBs) formation during meiotic recombination (PubMed:31000436, PubMed:31003867). Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation (PubMed:31000436, PubMed:31003867). Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes (PubMed:31000436). {ECO:0000269|PubMed:31000436, ECO:0000269|PubMed:31003867}.
uniprot
proteins
mass_dalton
206173
uniprot
proteins
mutagenesis
MUTAGEN 1818..1819; /note="YL->AA: Abolished interaction with REC114."; /evidence="ECO:0000269|PubMed:31003867"; MUTAGEN 1831; /note="E->A: Reduced interaction with REC114."; /evidence="ECO:0000269|PubMed:31003867"; MUTAGEN 1842; /note="W->A: Abolished interaction with REC114."; /evidence="ECO:0000269|PubMed:31003867
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
31000436
uniprot
proteins
pubmed
31003867
uniprot
proteins
sequence_length
1857
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31000436}. Chromosome {ECO:0000269|PubMed:31000436, ECO:0000269|PubMed:31003867}. Note=Localizes on chromatin between preleptotene and early pachytene (PubMed:31000436). Associates with the chromosome axes, but disappears from axes upon synaptonemal complex formation (PubMed:31000436). {ECO:0000269|PubMed:31000436}.
uniprot
proteins