Mib2
entrez
76580
canonical
uniprot
Q8R516
canonical
ensembl
ENSMUSG00000029060
resolver
ensp
ENSMUSP00000099465
resolver
ensp
ENSMUSP00000274827
resolver
ensp
ENSMUSP00000274828
resolver
ensp
ENSMUSP00000274830
resolver
ensp
ENSMUSP00000274837
resolver
ensp
ENSMUSP00000274839
resolver
ensp
ENSMUSP00000274846
resolver
ensp
ENSMUSP00000274884
resolver
ensp
ENSMUSP00000336796
resolver
genesymbol
Mib2
resolver
genesymbol_syn
Skd
resolver
uniprot
A2A9P9
resolver
uniprot
B2RUG2
resolver
uniprot
Q52QU8
resolver
uniprot
Q6PEF6
resolver
uniprot
Q8C1N7
resolver
uniprot
Q8VIB4
resolver
uniprot_entry
B2RUG2_MOUSE
resolver
uniprot_entry
MIB2_MOUSE
resolver
uniprot_sec
A2A9P9
resolver
uniprot_sec
Q52QU8
resolver
uniprot_sec
Q6PEF6
resolver
uniprot_sec
Q8C1N7
resolver
uniprot_sec
Q8VIB4
resolver
amino_acid_sequence
MDLDPHAGVQVGMRVVRGMDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGIRHPNIICDCCKKHGLRGMRWKCRVCFDYDLCTQCYMHNKHDLTHAFERYETSHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKTGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLRCVGEAAGGFYYKEHLPKLGKPAELQRRVSADGQPFQRGDKVKCLLDTDVLRDMQEGHGGWNPRMAEFIGQMGTVHRITDRGDVRVQFNHETRWTFHPGALTKHNSFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVGGQRWTFSPSCLVAYRPEEDANLDVAERARENKSAASVSVAGSLSVALDKLRTQKSDPEHPGRLVVEAALGNVARALDLLRRHPEQASYHPALVVDTKNQGRTALQVAAYLGQVELVRLLLQARASMDLPDDEGNTVLHYTAMGNQPEATRVLLSAGCAVDARNGTRSTALHVAVQRGFLEVVKILCERGCDVNLPDAHADTPLHSAISAGAGASSIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHVLAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQVLIREGRCDVNVRNRKLQSPLHLAVQQAHLGLVPLLVDAGCSVNTEDEEGDTALHVALQRHQLLPLVADRAGGDPGPLQLLSRLQASGLPGCTELTVGAAVACFLALEGADVSYANHRGRSPLDLATEGRVLKALQGCAQRFRERQAGGGGGVPPGPRHVLSTPNTVTNLHVSGTAGPEAAECLVCSELALLILFSPCQHRTVCEECARRMKKCIRCQVVISKKLRPDGSEVVNAIQVPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGAALNACPICRQPIRDRIQIFV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. {ECO:0000269|PubMed:15824097}.
uniprot
proteins
mass_dalton
105961
uniprot
proteins
mutagenesis
MUTAGEN 874; /note="C->S: No effect."; /evidence="ECO:0000269|PubMed:15824097"; MUTAGEN 951; /note="C->S: Abolishes ubiquitin ligase activity."; /evidence="ECO:0000269|PubMed:15824097
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Possibly via autoubiquitination. {ECO:0000269|PubMed:15824097}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15824097
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
973
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15824097}. Endosome {ECO:0000269|PubMed:15824097}. Note=Colocalizes with endosomal compartments.
uniprot
proteins