TRIAP1
entrez
51499
canonical
uniprot
O43715
canonical
ensembl
ENSG00000170855
resolver
ensp
ENSP00000449795
resolver
enst
ENST00000546954
resolver
genesymbol
TRIAP1
resolver
genesymbol_syn
15E1.1
resolver
hgnc
HGNC:26937
resolver
uniprot
B2R4Z7
resolver
uniprot
Q5RKS5
resolver
uniprot
Q6LCA7
resolver
uniprot_entry
TRIA1_HUMAN
resolver
uniprot_sec
B2R4Z7
resolver
uniprot_sec
Q5RKS5
resolver
uniprot_sec
Q6LCA7
resolver
amino_acid_sequence
MNSVGEACTDMKREYDQCFNRWFAEKFLKGDSSGDPCTDLFKRYQQCVQKAIKEKEIPIEGLEFMGHGKEKPENSS
uniprot
proteins
function
FUNCTION: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003). {ECO:0000269|PubMed:15735003, ECO:0000269|PubMed:23931759, ECO:0000269|PubMed:26071602}.
uniprot
proteins
mass_dalton
8786
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="F->A: Impairs interaction with PRELID3A."; /evidence="ECO:0000269|PubMed:26071602
uniprot
proteins
protein_family
TRIAP1/MDM35 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15735003
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23931759
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26071602
uniprot
proteins
sequence_length
76
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:15735003, ECO:0000269|PubMed:23931759}. Mitochondrion intermembrane space {ECO:0000269|PubMed:23931759}.
uniprot
proteins