ADARB2
entrez
105
canonical
uniprot
Q9NS39
canonical
ensembl
ENSG00000185736
resolver
ensp
ENSP00000370713
resolver
genesymbol
ADARB2
resolver
genesymbol_syn
ADAR3
resolver
genesymbol_syn
RED2
resolver
hgnc
HGNC:227
resolver
uniprot
B2RPJ5
resolver
uniprot
Q5VUT6
resolver
uniprot
Q5VW42
resolver
uniprot_entry
RED2_HUMAN
resolver
uniprot_sec
B2RPJ5
resolver
uniprot_sec
Q5VUT6
resolver
uniprot_sec
Q5VW42
resolver
amino_acid_sequence
MASVLGSGRGSGGLSSQLKCKSKRRRRRRSKRKDKVSILSTFLAPFKHLSPGITNTEDDDTLSTSSAEVKENRNVGNLAARPPPSGDRARGGAPGAKRKRPLEEGNGGHLCKLQLVWKKLSWSVAPKNALVQLHELRPGLQYRTVSQTGPVHAPVFAVAVEVNGLTFEGTGPTKKKAKMRAAELALRSFVQFPNACQAHLAMGGGPGPGTDFTSDQADFPDTLFQEFEPPAPRPGLAGGRPGDAALLSAAYGRRRLLCRALDLVGPTPATPAAPGERNPVVLLNRLRAGLRYVCLAEPAERRARSFVMAVSVDGRTFEGSGRSKKLARGQAAQAALQELFDIQMPGHAPGRARRTPMPQEFADSISQLVTQKFREVTTDLTPMHARHKALAGIVMTKGLDARQAQVVALSSGTKCISGEHLSDQGLVVNDCHAEVVARRAFLHFLYTQLELHLSKRREDSERSIFVRLKEGGYRLRENILFHLYVSTSPCGDARLHSPYEITTDLHSSKHLVRKFRGHLRTKIESGEGTVPVRGPSAVQTWDGVLLGEQLITMSCTDKIARWNVLGLQGALLSHFVEPVYLQSIVVGSLHHTGHLARVMSHRMEGVGQLPASYRHNRPLLSGVSDAEARQPGKSPPFSMNWVVGSADLEIINATTGRRSCGGPSRLCKHVLSARWARLYGRLSTRTPSPGDTPSMYCEAKLGAHTYQSVKQQLFKAFQKAGLGTWVRKPPEQQQFLLTL
uniprot
proteins
function
FUNCTION: Single- and double-stranded RNA-binding protein that interferes with the RNA editing activities of ADAR/ADAR1 and ADARB1/ADAR2. Likely competes with these proteins for target binding, repressing RNA editing across the transcriptome (PubMed:10836796, PubMed:28167531, PubMed:35850307). Additionally, it binds and stabilizes specific mRNAs and regulates the expression of proteins such as MAVS, DUSP1, and EGR1, independently of RNA editing mechanisms (PubMed:31552420, PubMed:35850307). {ECO:0000269|PubMed:10836796, ECO:0000269|PubMed:28167531, ECO:0000269|PubMed:31552420, ECO:0000269|PubMed:35850307}.
uniprot
proteins
mass_dalton
80621
uniprot
proteins
mutagenesis
MUTAGEN 389; /note="A->V: Novel double-stranded RNA adenosine deaminase activity; when associated with I-485, Q-527, R-549 and D-733."; /evidence="ECO:0000269|PubMed:31552420"; MUTAGEN 432..434; /note="HAE->AAA: No effect on negative regulation of RNA editing."; /evidence="ECO:0000269|PubMed:28167531"; MUTAGEN 485; /note="V->I: Novel double-stranded RNA adenosine deaminase activity; when associated with V-389, Q-527, R-549 and D-733."; /evidence="ECO:0000269|PubMed:31552420"; MUTAGEN 527; /note="E->Q: Novel double-stranded RNA adenosine deaminase activity; when associated with V-389, I-485, R-549 and D-733."; /evidence="ECO:0000269|PubMed:31552420"; MUTAGEN 549; /note="Q->R: Novel double-stranded RNA adenosine deaminase activity; when associated with V-389, I-485, Q-527 and D-733."; /evidence="ECO:0000269|PubMed:31552420"; MUTAGEN 733; /note="Q->D: Novel double-stranded RNA adenosine deaminase activity; when associated with V-389, I-485, Q-527 and R-549."; /evidence="ECO:0000269|PubMed:31552420
uniprot
proteins
pubmed
10836796
uniprot
proteins
pubmed
12618436
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18178553
uniprot
proteins
pubmed
19617375
uniprot
proteins
pubmed
28167531
uniprot
proteins
pubmed
31552420
uniprot
proteins
pubmed
35850307
uniprot
proteins
sequence_length
739
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:19617375}.
uniprot
proteins