SPAAR
entrez
158376
canonical
uniprot
A0A1B0GVQ0
canonical
ensembl
ENSG00000235387
resolver
ensp
ENSP00000490187
resolver
genesymbol
SPAAR
resolver
genesymbol_syn
LINC00961
resolver
genesymbol_syn
SPAR
resolver
hgnc
HGNC:27244
resolver
uniprot_entry
SPAR_HUMAN
resolver
amino_acid_sequence
MGAKAPRGPKVAQWAMETAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPVRHAQPVPSAQDFWTFM
uniprot
proteins
function
FUNCTION: [Isoform 2]: Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (PubMed:28024296). Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (PubMed:28024296). Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (By similarity). {ECO:0000250|UniProtKB:A0A1B0GSZ0, ECO:0000269|PubMed:28024296}.
uniprot
proteins
mass_dalton
9632
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
28024296
uniprot
proteins
sequence_length
90
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:28024296}; Single-pass membrane protein {ECO:0000305|PubMed:28024296}. Lysosome membrane {ECO:0000269|PubMed:28024296}; Single-pass membrane protein {ECO:0000305|PubMed:28024296}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins