Asgr1
entrez
11889
canonical
uniprot
P34927
canonical
ensembl
ENSMUSG00000020884
resolver
ensp
ENSMUSP00000018699
resolver
ensp
ENSMUSP00000090637
resolver
ensp
ENSMUSP00000104226
resolver
ensp
ENSMUSP00000121842
resolver
enst
ENSMUST00000018699
resolver
enst
ENSMUST00000092959
resolver
enst
ENSMUST00000108585
resolver
enst
ENSMUST00000146411
resolver
genesymbol
Asgr1
resolver
genesymbol_syn
Asgr-1
resolver
uniprot
B1AR34
resolver
uniprot
Q64363
resolver
uniprot
Q91Y84
resolver
uniprot_entry
ASGR1_MOUSE
resolver
uniprot_entry
B1AR34_MOUSE
resolver
uniprot_sec
Q64363
resolver
uniprot_sec
Q91Y84
resolver
amino_acid_sequence
MTKDYQDFQHLDNDNDHHQLRRGPPPTPRLLQRLCSGSRLLLLSSSLSILLLVVVCVITSQNSQLREDLLALRQNFSNLTVSTEDQVKALSTQGSSVGRKMKLVESKLEKQQKDLTEDHSSLLLHVKQLVSDVRSLSCQMAAFRGNGSERTCCPINWVEYEGSCYWFSSSVRPWTEADKYCQLENAHLVVVTSRDEQNFLQRHMGPLNTWIGLTDQNGPWKWVDGTDYETGFQNWRPEQPDNWYGHGLGGGEDCAHFTTDGRWNDDVCRRPYRWVCETKLDKAN
uniprot
proteins
function
FUNCTION: Transmembrane protein predominantly expressed on hepatocytes that plays a key role in endocytosis of plasma glycoproteins that lack terminal sialic acid residues. Specifically recognizes terminal galactose and N-acetylgalactosamine residues, facilitating the clearance of desialylated glycoproteins from circulation. Plays thereby a role in a variety of physiological processes, such as removal of desialylated platelets, elimination of activated lymphocytes and maintenance of serum glycoprotein homeostasis. Plays a role in the removal of desialylated platelets by activating a feedback loop regulating thrombopoietin (TPO) expression via the JAK2-STAT3 signaling pathway. Contributes also to recognition and elimination of activated lymphocytes by hepatocytes that can act as cytotoxic effectors (By similarity). May also play a physiological role in the regulatory network of lipid homeostasis (PubMed:34622799). Upon ligand binding, the receptor-ligand complex is internalized and trafficked to a sorting organelle, where dissociation occurs. The receptor is then recycled back to the cell surface (By similarity). {ECO:0000250|UniProtKB:P07306, ECO:0000269|PubMed:34622799}.
uniprot
proteins
mass_dalton
32591
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on a cytoplasmic Ser residue. {ECO:0000250|UniProtKB:P07306}.; PTM: Palmitoylated at Cys-35. Palmitoylation is essential for coated pit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes. {ECO:0000250|UniProtKB:P07306}.
uniprot
proteins
pubmed
10675034
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34622799
uniprot
proteins
pubmed
7958950
uniprot
proteins
pubmed
8439566
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins