INTS15
entrez
79034
canonical
uniprot
Q96N11
canonical
ensembl
ENSG00000146576
resolver
ensp
ENSP00000340220
resolver
ensp
ENSP00000351974
resolver
ensp
ENSP00000568783
resolver
ensp
ENSP00000674753
resolver
genesymbol
INTS15
resolver
genesymbol_syn
C7orf26
resolver
hgnc
HGNC:21702
resolver
uniprot
Q9BQ43
resolver
uniprot_entry
INT15_HUMAN
resolver
uniprot_sec
Q9BQ43
resolver
amino_acid_sequence
MSDIRHSLLRRDALSAAKEVLYHLDIYFSSQLQSAPLPIVDKGPVELLEEFVFQVPKERSAQPKRLNSLQELQLLEIMCNYFQEQTKDSVRQIIFSSLFSPQGNKADDSRMSLLGKLVSMAVAVCRIPVLECAASWLQRTPVVYCVRLAKALVDDYCCLVPGSIQTLKQIFSASPRFCCQFITSVTALYDLSSDDLIPPMDLLEMIVTWIFEDPRLILITFLNTPIAANLPIGFLELTPLVGLIRWCVKAPLAYKRKKKPPLSNGHVSNKVTKDPGVGMDRDSHLLYSKLHLSVLQVLMTLQLHLTEKNLYGRLGLILFDHMVPLVEEINRLADELNPLNASQEIELSLDRLAQALQVAMASGALLCTRDDLRTLCSRLPHNNLLQLVISGPVQQSPHAALPPGFYPHIHTPPLGYGAVPAHPAAHPALPTHPGHTFISGVTFPFRPIR
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:36920904, PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:38570683). INTS15 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386). Within the integrator complex, INTS15 is required to bridge different integrator modules (PubMed:36920904). {ECO:0000269|PubMed:36920904, ECO:0000269|PubMed:38570683, ECO:0000269|PubMed:38823386}.
uniprot
proteins
mass_dalton
50047
uniprot
proteins
mutagenesis
MUTAGEN 69..72; /note="LQEL->AQEA: Abolished interaction with INTS5, leading to Impaired assembly of the integrator complex."; /evidence="ECO:0000269|PubMed:38823386"; MUTAGEN 120..124; /note="MAVAV->AAVAA: Abolished interaction with INTS5, leading to Impaired assembly of the integrator complex."; /evidence="ECO:0000269|PubMed:38823386"; MUTAGEN 384..387; /note="LLQL->ALQA: Abolished interaction with INTS10."; /evidence="ECO:0000269|PubMed:36920904
uniprot
proteins
protein_family
Integrator subunit 15 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
33973408
uniprot
proteins
pubmed
36920904
uniprot
proteins
pubmed
38570683
uniprot
proteins
pubmed
38823386
uniprot
proteins
pubmed
39032490
uniprot
proteins
sequence_length
449
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:36920904, ECO:0000269|PubMed:39032490, ECO:0000305|PubMed:33973408}. Chromosome {ECO:0000269|PubMed:36920904}. Note=Associates to RNA polymerase II (Pol II) during active transcription. {ECO:0000269|PubMed:36920904}.
uniprot
proteins