Cxcr2
entrez
12765
canonical
uniprot
P35343
canonical
ensembl
ENSMUSG00000026180
resolver
ensp
ENSMUSP00000102512
resolver
enst
ENSMUST00000106899
resolver
genesymbol
Cxcr2
resolver
genesymbol_syn
Cmkar2
resolver
genesymbol_syn
Gpcr16
resolver
genesymbol_syn
Il8rb
resolver
uniprot
Q53X27
resolver
uniprot_entry
CXCR2_MOUSE
resolver
uniprot_sec
Q53X27
resolver
amino_acid_sequence
MGEFKVDKFNIEDFFSGDLDIFNYSSGMPSILPDAVPCHSENLEINSYAVVVIYVLVTLLSLVGNSLVMLVILYNRSTCSVTDVYLLNLAIADLFFALTLPVWAASKVNGWTFGSTLCKIFSYVKEVTFYSSVLLLACISMDRYLAIVHATSTLIQKRHLVKFVCIAMWLLSVILALPILILRNPVKVNLSTLVCYEDVGNNTSRLRVVLRILPQTFGFLVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLVFLLCWLPYNLVLFTDTLMRTKLIKETCERRDDIDKALNATEILGFLHSCLNPIIYAFIGQKFRHGLLKIMATYGLVSKEFLAKEGRPSFVSSSSANTSTTL
uniprot
proteins
function
FUNCTION: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. Signals intravascular neutrophil chemotaxis to the injury site (PubMed:20947763). {ECO:0000250|UniProtKB:P25025, ECO:0000269|PubMed:20947763}.
uniprot
proteins
mass_dalton
40425
uniprot
proteins
post_translational_modification
PTM: Phosphorylated upon ligand binding; which is required for desensitization. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14764687
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20947763
uniprot
proteins
pubmed
7518426
uniprot
proteins
pubmed
7636264
uniprot
proteins
pubmed
7961909
uniprot
proteins
pubmed
8194768
uniprot
proteins
pubmed
8288218
uniprot
proteins
pubmed
8288247
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 48..74; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 120..141; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 163..182; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 208..230; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 251..272; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 294..314; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins