MAP2K5
entrez
5607
canonical
uniprot
Q13163
canonical
ensembl
ENSG00000137764
resolver
ensp
ENSP00000178640
resolver
ensp
ENSP00000346493
resolver
ensp
ENSP00000378859
resolver
ensp
ENSP00000726075
resolver
ensp
ENSP00000726077
resolver
ensp
ENSP00000791335
resolver
genesymbol
MAP2K5
resolver
genesymbol_syn
MEK5
resolver
genesymbol_syn
MKK5
resolver
genesymbol_syn
PRKMK5
resolver
hgnc
HGNC:6845
resolver
uniprot
B4DE43
resolver
uniprot
Q92961
resolver
uniprot
Q92962
resolver
uniprot_entry
MP2K5_HUMAN
resolver
uniprot_sec
B4DE43
resolver
uniprot_sec
Q92961
resolver
uniprot_sec
Q92962
resolver
amino_acid_sequence
MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEERRSQQGPP
uniprot
proteins
ec_number
2.7.12.2
uniprot
proteins
function
FUNCTION: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). {ECO:0000250|UniProtKB:Q62862, ECO:0000269|PubMed:7759517, ECO:0000269|PubMed:9384584}.
uniprot
proteins
mass_dalton
50112
uniprot
proteins
mutagenesis
MUTAGEN 195; /note="K->M: Inactivation."; /evidence="ECO:0000269|PubMed:7759517"; MUTAGEN 311; /note="S->A: Inactivation."; /evidence="ECO:0000269|PubMed:7759517"; MUTAGEN 315; /note="T->A: Inactivation."; /evidence="ECO:0000269|PubMed:7759517
uniprot
proteins
post_translational_modification
PTM: Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. {ECO:0000250}.; PTM: (Microbial infection) Yersinia YopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway. {ECO:0000269|PubMed:16728640, ECO:0000269|PubMed:7759517}.
uniprot
proteins
protein_family
MAP kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
16728640
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
7759517
uniprot
proteins
pubmed
9384584
uniprot
proteins
sequence_length
448
uniprot
proteins