OATL1
entrez
4943
canonical
uniprot
Q3MII6
canonical
ensembl
ENSG00000068354
resolver
ensp
ENSP00000365962
resolver
ensp
ENSP00000528154
resolver
genesymbol
OATL1
resolver
genesymbol
TBC1D25
resolver
genesymbol_syn
OATL1
resolver
hgnc
HGNC:8092
resolver
uniprot
B4DF03
resolver
uniprot
Q08AN9
resolver
uniprot
Q3MII4
resolver
uniprot
Q8TAR9
resolver
uniprot_entry
B4DF03_HUMAN
resolver
uniprot_entry
TBC25_HUMAN
resolver
uniprot_sec
Q08AN9
resolver
uniprot_sec
Q3MII4
resolver
uniprot_sec
Q8TAR9
resolver
amino_acid_sequence
MATASGASDLSGSGAPPPGVGAQAAAAAEEEEREVVRVRVKKCESFLPPEFRSFAVDPQITSLDVLQHILIRAFDLSGKKNFGISYLGRDRLGQEVYLSLLSDWDLSTAFATASKPYLQLRVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADAGFGGHRGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLSEPLLNSPDPLLSSFSHPDSPSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPVPPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARALFADYLQSEVWDSEEGAEATAAS
uniprot
proteins
function
FUNCTION: Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. {ECO:0000269|PubMed:21383079}.
uniprot
proteins
mass_dalton
76327
uniprot
proteins
mutagenesis
MUTAGEN 134..135; /note="ED->AA: Severely affects interaction with GABARAP. Does not localize at autophagosomes."; /evidence="ECO:0000269|PubMed:21383079"; MUTAGEN 136; /note="W->A: Abolishes interaction with GABARAP. Does not localize at autophagosomes."; /evidence="ECO:0000269|PubMed:21383079
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21383079
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
688
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21383079}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:21383079}. Note=It is dispersed in the cytoplasm under nutrient-rich conditions. Localizes at autophagosomes under cell starving conditions.
uniprot
proteins