Dpyd
entrez
81656
canonical
uniprot
O89000
canonical
ensembl
ENSRNOG00000017105
resolver
ensp
ENSRNOP00000072507
resolver
enst
ENSRNOT00000086125
resolver
genesymbol
Dpyd
resolver
genesymbol_syn
DPD
resolver
uniprot
A0A0G2K355
resolver
uniprot_entry
A0A0G2K355_RAT
resolver
uniprot_entry
DPYD_RAT
resolver
amino_acid_sequence
MAGVLSRDAPDIESILALNPRIQAHATLRSTMAKKLDKKHWKRNTDKNCFTCEKLENNFDDIKHTTLGERGALREAVRCLKCADAPCQKSCPTSLDIKSFITSIANKNYYGAAKLIFSDNPLGLTCGMVCPTSDLCVGGCNLHATEEGPINIGGLQQFATEVFKAMNIPQIRSPLLPPPEHMPEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSISTDEMTLSTLKENGYKAAFIGIGLPEPKKDHIFQGLTQVQGFYTSKDFLPLVAKGSKPGMCACHSPLPSVRGAVIVLGAGDTAFDCATSALRCGARRVFIVFRKGFANIRAVPEEMELAKEEKCEFLPFLSPRKVIVKDGKIVGMQFVRTEQDETGNWVEDEEQIVRLKADVVISAFGSVLDDPKVIEALSPIKFNRWGLPEVNPETMQTSEPWVFAGGDVVGMANTTVESVNDGKQASWYIHKYIQAQYGALVPSQPTLPLFYTPVDLVDISVEMAGLRFPNPFGLASATPATSTPMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPLYGPGQSSFLNIELISEKTAAYWCHSVTELKADFPDNILIASIMCSYNKNDWMELSKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQSVRVPFFAKLTPNVTDIVSIARAAKEGGADGVTATNTVSGLMGLKADGSPWPSVGSGKRTTYGGVSGTAIRPIALRAVTAIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELSDWDGQSPPTMSHQKGKPVPHIAELMGQKLPSFGPYLERRKKILAASKIREKDQNRACSPLQRKHFNSQKPIPAIKDVIGKSLQYLGTFGELNVMEQVVALIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTVSDTCTGCTLCLSVCPIMDCIRMVSRATPYEPKRGLPLAVKPVC
uniprot
proteins
ec_number
1.3.1.2
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of uracil and thymine in the initial step of reductive pyrimidine catabolism, a pathway that yields beta-alanine from uracil and beta-aminoisobutyrate from thymine (By similarity). Also capable of degrading the chemotherapeutic drug 5-fluorouracil (By similarity). {ECO:0000250|UniProtKB:Q12882, ECO:0000250|UniProtKB:Q28943}.
uniprot
proteins
mass_dalton
111399
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; beta-alanine biosynthesis. {ECO:0000250|UniProtKB:Q12882}.
uniprot
proteins
protein_family
Dihydropyrimidine dehydrogenase family
uniprot
proteins
pubmed
39516046
uniprot
proteins
pubmed
9348115
uniprot
proteins
pubmed
9819714
uniprot
proteins
sequence_length
1025
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:9348115}.
uniprot
proteins