GABRA4
entrez
2557
canonical
uniprot
P48169
canonical
ensembl
ENSG00000109158
resolver
ensp
ENSP00000264318
resolver
ensp
ENSP00000570369
resolver
enst
ENST00000264318
resolver
genesymbol
GABRA4
resolver
hgnc
HGNC:4078
resolver
uniprot
Q8IYR7
resolver
uniprot
X5D7F5
resolver
uniprot_entry
GBRA4_HUMAN
resolver
uniprot_entry
X5D7F5_HUMAN
resolver
uniprot_sec
Q8IYR7
resolver
activity_regulation
ACTIVITY REGULATION: Potentiated by histamine. {ECO:0000269|PubMed:35355020}.
uniprot
proteins
amino_acid_sequence
MVSAKKVPAIALSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQEVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQESSKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFGSRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKSESLM
uniprot
proteins
function
FUNCTION: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:35355020). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:35355020). GABAARs containing alpha-4 are predominantly extrasynaptic, contributing to tonic inhibition in dentate granule cells and thalamic relay neurons (By similarity). Extrasynaptic alpha-4-containing GABAARs control levels of excitability and network activity (By similarity). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (PubMed:35355020). {ECO:0000250|UniProtKB:Q9D6F4, ECO:0000269|PubMed:35355020}.
uniprot
proteins
mass_dalton
61623
uniprot
proteins
protein_family
GABRA4 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
35355020
uniprot
proteins
pubmed
7607683
uniprot
proteins
pubmed
8719416
uniprot
proteins
sequence_length
554
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9D6F4}; Multi-pass membrane protein {ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN5}. Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN5}.
uniprot
proteins
transmembrane_region
TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN5"; TRANSMEM 285..305; /note="Helical"; /evidence="ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN5"; TRANSMEM 319..341; /note="Helical"; /evidence="ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN5"; TRANSMEM 518..540; /note="Helical"; /evidence="ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN5
uniprot
proteins