Rnf40
entrez
233900
canonical
uniprot
Q3U319
canonical
ensembl
ENSMUSG00000030816
resolver
ensp
ENSMUSP00000146310
resolver
ensp
ENSMUSP00000320533
resolver
ensp
ENSMUSP00000320534
resolver
enst
ENSMUST00000205694
resolver
genesymbol
Rnf40
resolver
genesymbol_syn
Bre1b
resolver
genesymbol_syn
Kiaa0661
resolver
uniprot
Q6ZQ75
resolver
uniprot
Q8BJA1
resolver
uniprot
Q8BY03
resolver
uniprot
Q8CHX4
resolver
uniprot_entry
BRE1B_MOUSE
resolver
uniprot_sec
Q6ZQ75
resolver
uniprot_sec
Q8BJA1
resolver
uniprot_sec
Q8BY03
resolver
uniprot_sec
Q8CHX4
resolver
amino_acid_sequence
MSGLSNKRAAGDGGSGPPEKKMNREEKTTTTLIEPIRLGGISSTEEMDSKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLQCYENQRELSSGTEVPGCQEGLTRDVIPRPDPGTSDLREPLPVQFRAPLSEPALAFVVALGASSCEEVELQLQGRMEFSKAAVSRVVEASDRLQRQVEELCQRVYSRGDSEAPGEVARVRTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSTETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSTGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLASKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSSHCIPTLSHPDDPGLNALAPGKEDSGPGPGGTPDCKKEMALLAGATSATSSIKKEELVSSEDDAQALTPVTQGLPSRGREPEARPKRELREREGPSLGPPPAASTLSRADREKAKVEEAKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPCCNTRKKDAVLTKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRVYIS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000250|UniProtKB:O75150}.
uniprot
proteins
mass_dalton
113967
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
BRE1 family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
1001
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O75150}.
uniprot
proteins