Inca1
entrez
103844
canonical
uniprot
Q6PKN7
canonical
ensembl
ENSMUSG00000057054
resolver
ensp
ENSMUSP00000073311
resolver
ensp
ENSMUSP00000104181
resolver
ensp
ENSMUSP00000104182
resolver
ensp
ENSMUSP00000104183
resolver
ensp
ENSMUSP00000118761
resolver
ensp
ENSMUSP00000212514
resolver
ensp
ENSMUSP00000212515
resolver
ensp
ENSMUSP00000212516
resolver
genesymbol
Inca1
resolver
uniprot
Q4VAE2
resolver
uniprot_entry
INCA1_MOUSE
resolver
uniprot_sec
Q4VAE2
resolver
amino_acid_sequence
MQGQEDGDSILPFAKCSRVVSRFSPCSLPPQNRRPMPQPYGDAFWENLSQRSSSNWMVEQYIPPILRATDCSRPSLHPLEGLPPPEKLWRRKRKKLHLERMQKGPGSIPARVRAVTYHLEDLRRRQGIINELKRAQWGSSDATPELPALEEGFELLSTTKYFDVEEERATYPQKETYSVTPRDQLLWTPWTPVGQQGTYASGQLSSLTYSTATARKNPVYDPQAMELESEE
uniprot
proteins
function
FUNCTION: Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor. Inhibits cell growth and proliferation and may play a role in cell cycle control (PubMed:21540187). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (PubMed:21750715). {ECO:0000269|PubMed:21540187, ECO:0000269|PubMed:21750715}.
uniprot
proteins
mass_dalton
26477
uniprot
proteins
post_translational_modification
PTM: Phosphorylated when part of a complex with CCNA1 and CDK2. {ECO:0000250|UniProtKB:Q0VD86}.
uniprot
proteins
protein_family
INCA family
uniprot
proteins
pubmed
15159402
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21540187
uniprot
proteins
pubmed
21750715
uniprot
proteins
sequence_length
231
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q0VD86}. Cytoplasm {ECO:0000250|UniProtKB:Q0VD86}.
uniprot
proteins