Kcnj13
entrez
94341
canonical
uniprot
O70617
canonical
ensembl
ENSRNOG00000016057
resolver
ensembl
ENSRNOG00055007883
resolver
ensembl
ENSRNOG00060010021
resolver
ensembl
ENSRNOG00065020440
resolver
ensp
ENSRNOP00000021507
resolver
ensp
ENSRNOP00055010631
resolver
ensp
ENSRNOP00060013229
resolver
ensp
ENSRNOP00065027707
resolver
enst
ENSRNOT00000021507
resolver
enst
ENSRNOT00055013255
resolver
enst
ENSRNOT00060016943
resolver
enst
ENSRNOT00065034560
resolver
genesymbol
Kcnj13
resolver
uniprot_entry
KCJ13_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Ba(2+) and Cs(+), although sensitivity to those inhibitors is much lower than in other Kir channels. {ECO:0000250|UniProtKB:O60928}.
uniprot
proteins
amino_acid_sequence
MDSRNCKVNAPLLSQRYRRMVTKDGHSTLQMDGAQRGLVYLRDAWGILMDMRWRWMMLVFSASFVVHWLVFAVLWYAVAEMNGDLEIDHDVPPENHTICVKHITSFTAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDLAVVAHKDGKPNLIFQVANTRPSPLTSVRVSAVLYQERENGELYQTSVDFHLDGISSEECPFFIFPLTYYHTITPSSPLATLLQHETPSHFELVVFLSAMQEGTGEICQRRTSYLPSEIMLHHRFAALMTRGSKGEYQVKMENFDKTVPEHPTPVVSKSPHRTDLDIHINGQSIDNFQIAETGLTE
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium. {ECO:0000250|UniProtKB:O60928}.
uniprot
proteins
mass_dalton
40637
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-201 by PKC strongly inhibits ionic currents, while phosphorylation at Ser-287 by PKA increases them. {ECO:0000250}.
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ13 subfamily
uniprot
proteins
pubmed
10871613
uniprot
proteins
pubmed
11042260
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P86046}. Note=Localized at the retinal pigmented epithelium (RPE) apical microvilli. {ECO:0000250|UniProtKB:P86046}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..77; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:P49655"; TRANSMEM 132..157; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:P49655
uniprot
proteins