Ints12
entrez
71793
canonical
uniprot
Q9D168
canonical
ensembl
ENSMUSG00000028016
resolver
ensp
ENSMUSP00000029650
resolver
enst
ENSMUST00000029650
resolver
genesymbol
Ints12
resolver
genesymbol_syn
Phf22
resolver
uniprot
Q3U2Q5
resolver
uniprot
Q921U2
resolver
uniprot_entry
INT12_MOUSE
resolver
uniprot_sec
Q3U2Q5
resolver
uniprot_sec
Q921U2
resolver
amino_acid_sequence
MAATVNLELDPIFLKALGFLHSKSKDSAEKLKALLDESLARGIDSSYRPTQKDVEPPKISSTKSLSIKQEPKTSSSLPSGSSNGKVLTAEKIKKEAEKRPADKMKDVTEGIDVPKKPRLEKPETRSSPITVQTSKDLSMADLSSFEETSADDFAMEMGLACVVCRQMTVASGNQLVECQECHNLYHQDCHKPQVTDKEVNDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPTVVSVTPTVKDPLVKKPETKLKQETTFLAFKRTEVKPSTVISGNSSSNNVSSSVTSGLTGWAAFAAKTSSAGPSTAKLNSAAQNSSGKPAASSSNQKPVGLTGLATSSKGGIGSKIGSGNSTSPSVPLKPLPPLTLGKTGLSRSVSCDNVSKVGLPSPSSLVPGGSSQLSGNGNSATTGPSGSTTSKATSETSSSTSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex. {ECO:0000250|UniProtKB:Q96CB8}.
uniprot
proteins
mass_dalton
48568
uniprot
proteins
post_translational_modification
PTM: Dephosphorylated at Ser-127 by the PNUTS-PP1 complex, promoting RNA polymerase II transcription pause-release. {ECO:0000250|UniProtKB:Q96CB8}.
uniprot
proteins
protein_family
Integrator subunit 12 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96CB8}.
uniprot
proteins