PAFAH1B2
entrez
5049
canonical
uniprot
P68402
canonical
ensembl
ENSG00000168092
resolver
ensp
ENSP00000388742
resolver
ensp
ENSP00000431365
resolver
ensp
ENSP00000434951
resolver
ensp
ENSP00000435289
resolver
genesymbol
HEL-S-303
resolver
genesymbol
PAFAH1B2
resolver
genesymbol_syn
PAFAHB
resolver
hgnc
HGNC:8575
resolver
uniprot
A8DPS5
resolver
uniprot
A8DPS6
resolver
uniprot
A8DPS7
resolver
uniprot
E9PEJ5
resolver
uniprot
E9PLP3
resolver
uniprot
O00687
resolver
uniprot
Q29459
resolver
uniprot
Q6IBR6
resolver
uniprot
V9HW44
resolver
uniprot_entry
PA1B2_HUMAN
resolver
uniprot_entry
V9HW44_HUMAN
resolver
uniprot_sec
A8DPS5
resolver
uniprot_sec
A8DPS6
resolver
uniprot_sec
A8DPS7
resolver
uniprot_sec
E9PEJ5
resolver
uniprot_sec
E9PLP3
resolver
uniprot_sec
O00687
resolver
uniprot_sec
Q29459
resolver
uniprot_sec
Q6IBR6
resolver
activity_regulation
ACTIVITY REGULATION: Beta subunit (PAFAH1B1) stimulates the acetylhydrolase activity of the alpha2/alpha2 catalytic homodimer. {ECO:0000250|UniProtKB:P68401}.
uniprot
proteins
amino_acid_sequence
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLLKVSLPKLANVQLLDTDGGFVHSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLEETPEEKQTTIA
uniprot
proteins
ec_number
3.1.1.47
uniprot
proteins
function
FUNCTION: Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity). {ECO:0000250|UniProtKB:P68401, ECO:0000250|UniProtKB:Q61206}.
uniprot
proteins
mass_dalton
25569
uniprot
proteins
protein_family
'GDSL' lipolytic enzyme family
uniprot
proteins
protein_family
Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15572112
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18155631
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9144386
uniprot
proteins
sequence_length
229
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins