Sln
entrez
66402
canonical
uniprot
Q9CQD6
canonical
ensembl
ENSMUSG00000042045
resolver
ensp
ENSMUSP00000036950
resolver
enst
ENSMUST00000048485
resolver
genesymbol
Sln
resolver
uniprot_entry
SARCO_MOUSE
resolver
amino_acid_sequence
MERSTQELFINFTVVLITVLLMWLLVRSYQY
uniprot
proteins
function
FUNCTION: Reversibly inhibits the activity of ATP2A1/SERCA1 and ATP2A2/SERCA2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:21697544, PubMed:22961106, PubMed:26816378, PubMed:31449798). Also inhibits the activity of ATP2A3/SERCA3 (PubMed:27923914). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle (PubMed:21697544, PubMed:26816378). Required for muscle-based, non-shivering thermogenesis (PubMed:22961106). {ECO:0000269|PubMed:21697544, ECO:0000269|PubMed:22961106, ECO:0000269|PubMed:26816378, ECO:0000269|PubMed:27923914, ECO:0000269|PubMed:31449798}.
uniprot
proteins
mass_dalton
3808
uniprot
proteins
protein_family
Sarcolipin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21697544
uniprot
proteins
pubmed
22961106
uniprot
proteins
pubmed
26816378
uniprot
proteins
pubmed
27923914
uniprot
proteins
pubmed
31449798
uniprot
proteins
sequence_length
31
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:26816378}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:27923914}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..26; /note="Helical"; /evidence="ECO:0000250
uniprot
proteins