PODXL2
entrez
50512
canonical
uniprot
Q9NZ53
canonical
ensembl
ENSG00000114631
resolver
ensp
ENSP00000345359
resolver
genesymbol
PODXL2
resolver
hgnc
HGNC:17936
resolver
uniprot
Q6UVY4
resolver
uniprot
Q8WUV6
resolver
uniprot_entry
PDXL2_HUMAN
resolver
uniprot_sec
Q6UVY4
resolver
uniprot_sec
Q8WUV6
resolver
amino_acid_sequence
MGRLLRAARLPPLLSPLLLLLVGGAFLGACVAGSDEPGPEGLTSTSLLDLLLPTGLEPLDSEEPSETMGLGAGLGAPGSGFPSEENEESRILQPPQYFWEEEEELNDSSLDLGPTADYVFPDLTEKAGSIEDTSQAQELPNLPSPLPKMNLVEPPWHMPPREEEEEEEEEEEREKEEVEKQEEEEEEELLPVNGSQEEAKPQVRDFSLTSSSQTPGATKSRHEDSGDQASSGVEVESSMGPSLLLPSVTPTTVTPGDQDSTSQEAEATVLPAAGLGVEFEAPQEASEEATAGAAGLSGQHEEVPALPSFPQTTAPSGAEHPDEDPLGSRTSASSPLAPGDMELTPSSATLGQEDLNQQLLEGQAAEAQSRIPWDSTQVICKDWSNLAGKNYIILNMTENIDCEVFRQHRGPQLLALVEEVLPRHGSGHHGAWHISLSKPSEKEQHLLMTLVGEQGVVPTQDVLSMLGDIRRSLEEIGIQNYSTTSSCQARASQVRSDYGTLFVVLVVIGAICIIIIALGLLYNCWQRRLPKLKHVSHGEELRFVENGCHDNPTLDVASDSQSEMQEKHPSLNGGGALNGPGSWGALMGGKRDPEDSDVFEEDTHL
uniprot
proteins
function
FUNCTION: Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins. {ECO:0000269|PubMed:18606703}.
uniprot
proteins
mass_dalton
65076
uniprot
proteins
mutagenesis
MUTAGEN 97; /note="Y->F: Remains sulfated. Not sulfated and reduced rolling of Jurkat T-cells by more than 50%; when associated with F-118. The rolling of Jurkat T-cells is reduced by more than 80%; when associated with F-118 and A-124."; /evidence="ECO:0000269|PubMed:12889478"; MUTAGEN 118; /note="Y->F: Remains sulfated. Not sulfated and reduced rolling of Jurkat T-cells by more than 50%; when associated with F-97. The rolling of Jurkat T-cells is reduced by more than 80%; when associated with F-97 and A-124."; /evidence="ECO:0000269|PubMed:12889478"; MUTAGEN 124; /note="T->A: Reduced sialylation."; /evidence="ECO:0000269|PubMed:12889478
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains chondroitin sulfate. Displays sialylated O-linked oligosaccharides. {ECO:0000269|PubMed:10722749, ECO:0000269|PubMed:12889478}.; PTM: Sulfation is necessary for interaction with SELL. Sialylated O-linked oligosaccharides are necessary for interaction with SELL, SELE and SELP. {ECO:0000269|PubMed:12889478}.
uniprot
proteins
protein_family
Podocalyxin family
uniprot
proteins
pubmed
10722749
uniprot
proteins
pubmed
12889478
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18606703
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23234360
uniprot
proteins
sequence_length
605
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 501..521; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins