TNKS1BP1
entrez
85456
canonical
uniprot
Q9C0C2
canonical
ensembl
ENSG00000149115
resolver
ensp
ENSP00000350990
resolver
ensp
ENSP00000633576
resolver
ensp
ENSP00000711972
resolver
genesymbol
TNKS1BP1
resolver
genesymbol_syn
KIAA1741
resolver
genesymbol_syn
TAB182
resolver
hgnc
HGNC:19081
resolver
uniprot
A0A024R542
resolver
uniprot
A7E2F8
resolver
uniprot
Q6PJ35
resolver
uniprot
Q6ZV74
resolver
uniprot_entry
A0A024R542_HUMAN
resolver
uniprot_entry
TB182_HUMAN
resolver
uniprot_sec
A7E2F8
resolver
uniprot_sec
Q6PJ35
resolver
uniprot_sec
Q6ZV74
resolver
amino_acid_sequence
MKVSTLRESSAMASPLPREMEEELVPTGSEPGDTRAKPPVKPKPRALPAKPALPAKPSLLVPVGPRPPRGPLAELPSARKMNMLAGPQPYGGSKRPLPFAPRPAVEASTGGEATQETGKEEAGKEEPPPLTPPARCAAPGGVRKAPAPFRPASERFAATTVEEILAKMEQPRKEVLASPDRLWGSRLTFNHDGSSRYGPRTYGTTTAPRDEDGSTLFRGWSQEGPVKSPAECREEHSKTPEERSLPSDLAFNGDLAKAASSELPADISKPWIPSSPAPSSENGGPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQLLEAQTPEASQASPCPAVTPSAPSAALPDEGSRHTPSPGLPAEGAPEAPRPSSPPPEVLEPHSLDQPPATSPRPLIEVGELLDLTRTFPSGGEEEAKGDAHLRPTSLVQRRFSEGVLQSPSQDQEKLGGSLAALPQGQGSQLALDRPFGAESNWSLSQSFEWTFPTRPSGLGVWRLDSPPPSPITEASEAAEAAEAGNLAVSSREEGVSQQGQGAGSAPSGSGSSWVQGDDPSMSLTQKGDGESQPQFPAVPLEPLPTTEGTPGLPLQQAEERYESQEPLAGQESPLPLATREAALPILEPVLGQEQPAAPDQPCVLFADAPEPGQALPVEEEAVTLARAETTQARTEAQDLCRASPEPPGPESSSRWLDDLLASPPPSGGGARRGAGAELKDTQSPSTCSEGLLGWSQKDLQSEFGITGDPQPSSFSPSSWCQGASQDYGLGGASPRGDPGLGERDWTSKYGQGAGEGSTREWASRCGIGQEEMEASSSQDQSKVSAPGVLTAQDRVVGKPAQLGTQRSQEADVQDWEFRKRDSQGTYSSRDAELQDQEFGKRDSLGTYSSRDVSLGDWEFGKRDSLGAYASQDANEQGQDLGKRDHHGRYSSQDADEQDWEFQKRDVSLGTYGSRAAEPQEQEFGKSAWIRDYSSGGSSRTLDAQDRSFGTRPLSSGFSPEEAQQQDEEFEKKIPSVEDSLGEGSRDAGRPGERGSGGLFSPSTAHVPDGALGQRDQSSWQNSDASQEVGGHQERQQAGAQGPGSADLEDGEMGKRGWVGEFSLSVGPQREAAFSPGQQDWSRDFCIEASERSYQFGIIGNDRVSGAGFSPSSKMEGGHFVPPGKTTAGSVDWTDQLGLRNLEVSSCVGSGGSSEARESAVGQMGWSGGLSLRDMNLTGCLESGGSEEPGGIGVGEKDWTSDVNVKSKDLAEVGEGGGHSQARESGVGQTDWSGVEAGEFLKSRERGVGQADWTPDLGLRNMAPGAVCSPGESKELGVGQMDWGNNLGLRDLEVTCDPDSGGSQGLRGCGVGQMDWTQDLAPQNVELFGAPSEAREHGVGGVSQCPEPGLRHNGSLSPGLEARDPLEARELGVGETSGPETQGEDYSSSSLEPHPADPGMETGEALSFGASPGRCPARPPPSGSQGLLEEMLAASSSKAVARRESAASGLGGLLEEEGAGAGAAQEEVLEPGRDSPPSWRPQPDGEASQTEDVDGTWGSSAARWSDQGPAQTSRRPSQGPPARSPSQDFSFIEDTEILDSAMYRSRANLGRKRGHRAPVIRPGGTLGLSEAADSDAHLFQDSTEPRASRVPSSDEEVVEEPQSRRTRMSLGTKGLKVNLFPGLSPSALKAKLRPRNRSAEEGELAESKSSQKESAVQRSKSCKVPGLGKPLTLPPKPEKSSGSEGSSPNWLQALKLKKKKV
uniprot
proteins
function
FUNCTION: Component of the CCR4-NOT complex, a large multiprotein complex with several proteins assembled around the scaffolding protein CNOT1 (PubMed:29593045, PubMed:31180491). This complex is one of the major cellular mRNA deadenylase and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. CNOT12 affects helicase selection into the CCR4-NOT complex (PubMed:29593045, PubMed:31180491). In addition, plays a role in DNA double strand break repair and is involved in actin cytoskeleton rearrangement and cancer cell invasion (PubMed:25749521, PubMed:28202517). {ECO:0000269|PubMed:25749521, ECO:0000269|PubMed:28202517, ECO:0000269|PubMed:29593045, ECO:0000269|PubMed:31180491}.
uniprot
proteins
mass_dalton
181796
uniprot
proteins
post_translational_modification
PTM: Highly phosphorylated by ATM or ATR in response to ionizing radiation-induced DNA damage. {ECO:0000269|PubMed:17525332}.
uniprot
proteins
pubmed
11214970
uniprot
proteins
pubmed
11854288
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12693554
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17487921
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25749521
uniprot
proteins
pubmed
28202517
uniprot
proteins
pubmed
29593045
uniprot
proteins
pubmed
31180491
uniprot
proteins
sequence_length
1729
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11854288}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11854288, ECO:0000269|PubMed:28202517}. Chromosome {ECO:0000269|PubMed:11854288}. Note=Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin. {ECO:0000269|PubMed:11854288}.
uniprot
proteins