Grb10
entrez
14783
canonical
uniprot
Q60760
canonical
ensembl
ENSMUSG00000020176
resolver
ensp
ENSMUSP00000091011
resolver
ensp
ENSMUSP00000105281
resolver
ensp
ENSMUSP00000160866
resolver
ensp
ENSMUSP00000160867
resolver
genesymbol
Grb10
resolver
genesymbol_syn
Meg1
resolver
uniprot
O35352
resolver
uniprot
Q3TQ71
resolver
uniprot
Q7TSA4
resolver
uniprot
Q8BSH4
resolver
uniprot
Q8BSS5
resolver
uniprot
Q91WC5
resolver
uniprot_entry
GRB10_MOUSE
resolver
uniprot_sec
O35352
resolver
uniprot_sec
Q3TQ71
resolver
uniprot_sec
Q7TSA4
resolver
uniprot_sec
Q8BSH4
resolver
uniprot_sec
Q8BSS5
resolver
uniprot_sec
Q91WC5
resolver
activity_regulation
ACTIVITY REGULATION: Phosphorylation by mTORC1 stabilizes and activates GRB10 constituting a feedback pathway by which mTORC1 inhibits INSR-dependent signaling. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MNNDINSSVESLNSACNMQSDTDTAPLLEDGQHASNQGAASSSRGQPQASPRQKMQRSQPVHILRRLQEEDQQLRTASLPAIPNPFPELTGAAPGSPPSVAPSSLPPPPSQPPAKHCGRCEKWIPGENTRGNGKRKIWRWQFPPGFQLSKLTRPGLWTKTTARFSKKQPKNQCPTDTVNPVARMPTSQMEKLRLRKDVKVFSEDGTSKVVEILTDMTARDLCQLLVYKSHCVDDNSWTLVEHHPQLGLERCLEDHEIVVQVESTMPSESKFLFRKNYAKYEFFKNPVNFFPDQMVNWCQQSNGGQAQLLQNFLNTSSCPEIQGFLQVKEVGRKSWKKLYVCLRRSGLYYSTKGTSKEPRHLQLLADLEESSIFYLIAGKKQYNAPNEHGMCIKPNKAKTEMKELRLLCAEDEQIRTCWMTAFRLLKYGMLLYQNYRIPQRKGLPPPFNAPMRSVSENSLVAMDFSGQIGRVIDNPAEAQSAALEEGHAWRKRSTRMNILSSQSPLHPSTLNAVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFTLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
uniprot
proteins
function
FUNCTION: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination also has been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12697834, ECO:0000269|PubMed:12829789, ECO:0000269|PubMed:15664450, ECO:0000269|PubMed:17376403, ECO:0000269|PubMed:18286479}.
uniprot
proteins
mass_dalton
70585
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues upon EGF, FGF and PDGF stimulation. {ECO:0000269|PubMed:15722337, ECO:0000269|PubMed:7731717}.
uniprot
proteins
protein_family
GRB7/10/14 family
uniprot
proteins
pubmed
10454568
uniprot
proteins
pubmed
10861285
uniprot
proteins
pubmed
12697834
uniprot
proteins
pubmed
12771153
uniprot
proteins
pubmed
12829789
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15664450
uniprot
proteins
pubmed
15722337
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17376403
uniprot
proteins
pubmed
18286479
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7731717
uniprot
proteins
pubmed
9062339
uniprot
proteins
pubmed
9448292
uniprot
proteins
sequence_length
621
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18286479}. Note=When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R before the sorting of the receptor to the lysosomal compartment.
uniprot
proteins