ATP10B
entrez
23120
canonical
uniprot
O94823
canonical
ensembl
ENSG00000118322
resolver
ensp
ENSP00000313600
resolver
ensp
ENSP00000493802
resolver
ensp
ENSP00000613187
resolver
enst
ENST00000642502
resolver
genesymbol
ATP10B
resolver
genesymbol_syn
ATPVB
resolver
genesymbol_syn
KIAA0715
resolver
hgnc
HGNC:13543
resolver
uniprot
A0A2R8YDI5
resolver
uniprot
Q9H725
resolver
uniprot_entry
A0A2R8YDI5_HUMAN
resolver
uniprot_entry
AT10B_HUMAN
resolver
uniprot_sec
Q9H725
resolver
amino_acid_sequence
MALSVDSSWHRWQWRVRDGFPHCPSETTPLLSPEKGRQSYNLTQQRVVFPNNSIFHQDWEEVSRRYPGNRTCTTKYTLFTFLPRNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITMLPLAIVLFVIMIKDGMEDFKRHRFDKAINCSNIRIYERKEQTYVQKCWKDVRVGDFIQMKCNEIVPADILLLFSSDPNGICHLETASLDGETNLKQRCVVKGFSQQEVQFEPELFHNTIVCEKPNNHLNKFKGYMEHPDQTRTGFGCESLLLRGCTIRNTEMAVGIVIYAGHETKAMLNNSGPRYKRSKIERRMNIDIFFCIGILILMCLIGAVGHSIWNGTFEEHPPFDVPDANGSFLPSALGGFYMFLTMIILLQVLIPISLYVSIELVKLGQVFFLSNDLDLYDEETDLSIQCRALNIAEDLGQIQYIFSDKTGTLTENKMVFRRCTIMGSEYSHQENAKRLETPKELDSDGEEWTQYQCLSFSARWAQDPATMRSQKGAQPLRRSQSARVPIQGHYRQRSMGHRESSQPPVAFSSSIEKDVTPDKNLLTKVRDAALWLETLSDSRPAKASLSTTSSIADFFLALTICNSVMVSTTTEPRQRVTIKPSSKALGTSLEKIQQLFQKLKLLSLSQSFSSTAPSDTDLGESLGANVATTDSDERDDASVCSGGDSTDDGGYRSSMWDQGDILESGSGTSLEEALEAPATDLARPEFCYEAESPDEAALVHAAHAYSFTLVSRTPEQVTVRLPQGTCLTFSLLCTLGFDSVRKRMSVVVRHPLTGEIVVYTKGADSVIMDLLEDPACVPDINMEKKLRKIRARTQKHLDLYARDGLRTLCIAKKVVSEEDFRRWASFRREAEASLDNRDELLMETAQHLENQLTLLGATGIEDRLQEGVPDTIATLREAGIQLWVLTGDKQETAVNIAHSCRLLNQTDTVYTINTENQETCESILNCALEELKQFRELQKPDRKLFGFRLPSKTPSITSEAVVPEAGLVIDGKTLNAIFQGKLEKKFLELTQYCRSVLCCRSTPLQKSMIVKLVRDKLRVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMSSDFAITRFKHLKKLLLVHGHWCYSRLARMVVYYLYKNVCYVNLLFWYQFFCGFSSSTMIDYWQMIFFNLFFTSLPPLVFGVLDKDISAETLLALPELYKSGQNSECYNLSTFWISMVDAFYQSLICFFIPYLAYKGSDIDVFTFGTPINTISLTTILLHQAMEMKTWTIFHGVVLLGSFLMYFLVSLLYNATCVICNSPTNPYWVMEGQLSNPTFYLVCFLTPVVALLPRYFFLSLQGTCGKSLISKAQKIDKLPPDKRNLEIQSWRSRQRPAPVPEVARPTHHPVSSITGQDFSASTPKSSNPPKRKHVEESVLHEQRCGTECMRDDSCSGDSSAQLSSGEHLLGPNRIMAYSRGQTDMCRCSKRSSHRRSQSSLTI
uniprot
proteins
ec_number
7.6.2.1
uniprot
proteins
function
FUNCTION: Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons. {ECO:0000269|PubMed:32172343}.
uniprot
proteins
mass_dalton
165391
uniprot
proteins
mutagenesis
MUTAGEN 210; /note="E->A: Loss of ATPase flippase activity."; /evidence="ECO:0000269|PubMed:32172343"; MUTAGEN 433; /note="D->N: Abolishes autophosphorylation and ATPase flippase activity."; /evidence="ECO:0000269|PubMed:32172343
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated at the conserved aspartate of the P-type ATPase signature sequence. {ECO:0000269|PubMed:32172343}.
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IV subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
25947375
uniprot
proteins
pubmed
32172343
uniprot
proteins
pubmed
32892229
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
1461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:32172343}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:32172343}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:25947375}; Multi-pass membrane protein {ECO:0000255}. Note=Exit from the endoplasmic reticulum requires the presence of CDC50A, but not CDC50B.
uniprot
proteins
transmembrane_region
TRANSMEM 83..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 111..132; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 317..338; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 369..390; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1112..1132; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1145..1164; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1195..1216; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1224..1246; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1253..1273; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1292..1316; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins