Csrp3
entrez
13009
canonical
uniprot
P50462
canonical
ensembl
ENSMUSG00000030470
resolver
ensp
ENSMUSP00000032658
resolver
ensp
ENSMUSP00000129378
resolver
enst
ENSMUST00000032658
resolver
enst
ENSMUST00000167786
resolver
genesymbol
Csrp3
resolver
genesymbol_syn
Clp
resolver
genesymbol_syn
Mlp
resolver
uniprot
Q545C7
resolver
uniprot_entry
CSRP3_MOUSE
resolver
uniprot_entry
Q545C7_MOUSE
resolver
amino_acid_sequence
MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRRYGPKGIGFGQGAGCLSTDTGEHLGLQFQQSPKPARAATTSNPSKFSAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTQQVEKKE
uniprot
proteins
function
FUNCTION: Positive regulator of myogenesis. Acts as a cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (PubMed:15665106, PubMed:9039266). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly. Proposed to contribute to the maintenance of muscle cell integrity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (By similarity). In vitro can inhibit PKC/PRKCA activity. Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (PubMed:27353086). {ECO:0000250|UniProtKB:P50461, ECO:0000250|UniProtKB:P50463, ECO:0000269|PubMed:15665106, ECO:0000269|PubMed:27353086, ECO:0000269|PubMed:9039266}.
uniprot
proteins
mass_dalton
20895
uniprot
proteins
mutagenesis
MUTAGEN 4; /note="W->R: Mice develop an age- and gene dosage-dependent hypertrophic cardiomyopathy and heart failure phenotype, characterized by almost complete loss of contractile reserve under catecholamine induced stress. They display increased in septum wall thickness, fractional shortening, and wall thickness per diameter (h/r). There is also evidence for skeletal muscle pathology. In addition, homozygous mutants show increased left ventricle (LC) mass per body weight (BW) and significantly reduced body weight. An increased nuclear localization of Csrp3 is also observed. Decreases interaction with TCAP."; /evidence="ECO:0000269|PubMed:20044516
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKC/PRKCA. {ECO:0000250|UniProtKB:P50461}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15665106
uniprot
proteins
pubmed
18258855
uniprot
proteins
pubmed
20044516
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27353086
uniprot
proteins
pubmed
8773898
uniprot
proteins
pubmed
9039266
uniprot
proteins
sequence_length
194
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P50463}. Cytoplasm {ECO:0000269|PubMed:18258855}. Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:18258855}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:P50461}. Note=Nucleocytoplasmic shuttling protein (By similarity). Mainly cytoplasmic. In the Z line, found associated with GLRX3 (via C-terminus). {ECO:0000250|UniProtKB:P50463, ECO:0000269|PubMed:18258855}.
uniprot
proteins