Letm1
entrez
56384
canonical
uniprot
Q9Z2I0
canonical
ensembl
ENSMUSG00000005299
resolver
ensp
ENSMUSP00000005431
resolver
enst
ENSMUST00000005431
resolver
genesymbol
Letm1
resolver
uniprot
Q5PQC5
resolver
uniprot
Q7TMK8
resolver
uniprot
Q80ZX6
resolver
uniprot
Q8CGJ3
resolver
uniprot
Q8K5E5
resolver
uniprot_entry
LETM1_MOUSE
resolver
uniprot_sec
Q5PQC5
resolver
uniprot_sec
Q7TMK8
resolver
uniprot_sec
Q80ZX6
resolver
uniprot_sec
Q8CGJ3
resolver
uniprot_sec
Q8K5E5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by ruthenium red or its derivative Ru360. {ECO:0000250|UniProtKB:O95202}.
uniprot
proteins
amino_acid_sequence
MASILLRSCRGRGPARLAPPRAASPRGSLRDRACLSCTRTLGLTSRESVLSRCCTPAHPVYLCFKGEPLSCWTQRPECQGTAARTTWTPASARLVVTGPQYLPVRGWHSSSPLGEDSVIEKSLKSLKDKNKKLEEGGPVYSPPAQVVVRKSLGQKVLDELRHYYHGFRLLWIDTKIAARMLWRILNGHTLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVVVKLFPNMLPSTFETQSIKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGNATKDFSAFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLISEEGVDSLTVKELQAACRARGMRALGVTEDRLKGQLKQWLDLHLHHEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEKVDNKAKLEATLQEEAAIQQEHLEELKRASEAVKDIQPEVAEATLPGRPGPEPQPPVDDVILPSEVLTDTAPVLEGLKGEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYIEESAASKRLSKRVQQMIGQIDGLITQLETTQQDGKLGPSQSTPTGESVISITELISAMKQIKHIPEHKLISLTSALDDNKDGNINIDDLVKVIDLVNKEDVQISTTQVAEIVATLEKEEKIEEKEKAKEKAEKEAAEVKN
uniprot
proteins
function
FUNCTION: Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:23716663, PubMed:27669901). Mediates proton-dependent calcium efflux from mitochondrion (PubMed:23716663, PubMed:27669901). Functions also as an electroneutral mitochondrial proton/potassium exchanger (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). Essential for early embryonic development (PubMed:23716663). {ECO:0000250|UniProtKB:O95202, ECO:0000269|PubMed:23716663, ECO:0000269|PubMed:27669901}.
uniprot
proteins
mass_dalton
82989
uniprot
proteins
mutagenesis
MUTAGEN 204; /note="D->N: Does not affect mitochondrial localization and ability to mediate calcium efflux from mitochondrion."; /evidence="ECO:0000269|PubMed:27669901"; MUTAGEN 221; /note="E->Q: Does not affect mitochondrial localization but abolishes ability to mediate calcium efflux from mitochondrion."; /evidence="ECO:0000269|PubMed:27669901"; MUTAGEN 246..247; /note="EE->AA: Does not affect mitochondrial localization and ability to mediate calcium efflux from mitochondrion."; /evidence="ECO:0000269|PubMed:27669901
uniprot
proteins
post_translational_modification
PTM: PINK1-mediated phosphorylation at Thr-191, positively regulates its mitochondrial calcium transport activity. {ECO:0000250|UniProtKB:O95202}.
uniprot
proteins
protein_family
LETM1 family
uniprot
proteins
pubmed
10486213
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23716663
uniprot
proteins
pubmed
27669901
uniprot
proteins
sequence_length
738
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:27669901}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 208..228; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins