CD93
entrez
22918
canonical
uniprot
Q9NPY3
canonical
ensembl
ENSG00000125810
resolver
ensp
ENSP00000246006
resolver
ensp
ENSP00000520912
resolver
ensp
ENSP00000520913
resolver
ensp
ENSP00000520914
resolver
enst
ENST00000246006
resolver
enst
ENST00000850633
resolver
enst
ENST00000850634
resolver
enst
ENST00000850635
resolver
genesymbol
CD93
resolver
genesymbol_syn
C1QR1
resolver
genesymbol_syn
MXRA4
resolver
hgnc
HGNC:15855
resolver
uniprot
O00274
resolver
uniprot_entry
C1QR1_HUMAN
resolver
uniprot_sec
O00274
resolver
amino_acid_sequence
MATSMGLLLLLLLLLTQPGAGTGADTEAVVCVGTACYTAHSGKLSAAEAQNHCNQNGGNLATVKSKEEAQHVQRVLAQLLRREAALTARMSKFWIGLQREKGKCLDPSLPLKGFSWVGGGEDTPYSNWHKELRNSCISKRCVSLLLDLSQPLLPSRLPKWSEGPCGSPGSPGSNIEGFVCKFSFKGMCRPLALGGPGQVTYTTPFQTTSSSLEAVPFASAANVACGEGDKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLGPPSGPPDEEDKGEKEGSTVPRAATASPTRGPEGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGSPGVWREPSIHHATAASGPQEPAGGDSSVATQNNDGTDGQKLLLFYILGTVVAILLLLALALGLLVYRKRRAKREEKKEKKPQNAADSYSWVPERAESRAMENQYSPTPGTDC
uniprot
proteins
function
FUNCTION: Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2) (PubMed:7977768). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis (PubMed:24809468). Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration (PubMed:26848865). Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands (PubMed:28671670, PubMed:36265539, PubMed:38218180). Both ligands play a non-redundant role in CD93-mediated endothelial cell function (PubMed:38218180). Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function (By similarity). {ECO:0000250|UniProtKB:O89103, ECO:0000269|PubMed:24809468, ECO:0000269|PubMed:26848865, ECO:0000269|PubMed:28671670, ECO:0000269|PubMed:36265539, ECO:0000269|PubMed:38218180, ECO:0000269|PubMed:7977768}.
uniprot
proteins
mass_dalton
68560
uniprot
proteins
mutagenesis
MUTAGEN 104; /note="C->S: Loss of interaction with MMRN2."; /evidence="ECO:0000269|PubMed:28671670"; MUTAGEN 136; /note="C->S: Loss of interaction with MMRN2."; /evidence="ECO:0000269|PubMed:28671670"; MUTAGEN 276; /note="F->A: Loss of interaction with IGFBP7."; /evidence="ECO:0000269|PubMed:38218180"; MUTAGEN 295; /note="D->A: Loss of interaction with IGFBP7."; /evidence="ECO:0000269|PubMed:38218180
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated. {ECO:0000269|PubMed:10092817}.; PTM: Phosphorylated on Tyr-628 and Tyr-644 by SRC; these phosphorylations promote endothelial cell adhesion and migration. {ECO:0000269|PubMed:26848865}.
uniprot
proteins
pubmed
10092817
uniprot
proteins
pubmed
11086025
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
11781389
uniprot
proteins
pubmed
11994479
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
24809468
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26848865
uniprot
proteins
pubmed
28671670
uniprot
proteins
pubmed
36265539
uniprot
proteins
pubmed
38218180
uniprot
proteins
pubmed
7977768
uniprot
proteins
pubmed
9047234
uniprot
proteins
pubmed
9233640
uniprot
proteins
sequence_length
652
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24809468, ECO:0000269|PubMed:26848865}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 581..601; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins