D4ADX7
uniprot
D4ADX7
canonical
amino_acid_sequence
MDASAEQSLPEPGSQDSVAGDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCMGTIPELQVVDSEGNRVEHPTLENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLETAAKHELELMELNSSSAESKPGGSRSDLDTLPPEPAAREGPSWGSRLKLSHSDTFIPLLTEEKHHRTRLQSCK
uniprot
proteins
function
FUNCTION: Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization (PubMed:9305895, PubMed:9696692). Accelerates inactivation but has relatively little effect on deactivation (PubMed:9696692). Coexpression with KCNB1 or KCNB2 markedly slows inactivation (PubMed:9305895). Each modulatory subunit has its own specific properties of regulation, and can lead to extensive inhibitions, to large changes in kinetics, and/or to large shifts in the voltage dependencies of the inactivation process (PubMed:9305895). The gating kinetics depends on the nature and stoichiometry of the associated regulatory sunbunit (PubMed:9305895, PubMed:9696692). Fails to produce a potassium current when expressed alone (PubMed:9305895). {ECO:0000269|PubMed:9305895, ECO:0000269|PubMed:9696692}.
uniprot
proteins
mass_dalton
55663
uniprot
proteins
protein_family
F (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv5.1/KCNF1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
1740690
uniprot
proteins
pubmed
9305895
uniprot
proteins
pubmed
9696692
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q14721}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 184..204; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 250..270; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 290..310; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 325..345; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 386..406; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins