Kif2c
entrez
73804
canonical
uniprot
Q922S8
canonical
ensembl
ENSMUSG00000028678
resolver
ensp
ENSMUSP00000064261
resolver
ensp
ENSMUSP00000102044
resolver
enst
ENSMUST00000065896
resolver
enst
ENSMUST00000106436
resolver
genesymbol
Kif2c
resolver
uniprot
A2AE71
resolver
uniprot
F7AFY8
resolver
uniprot
Q3TTL2
resolver
uniprot
Q3UD72
resolver
uniprot_entry
F7AFY8_MOUSE
resolver
uniprot_entry
KIF2C_MOUSE
resolver
uniprot_entry
Q3TTL2_MOUSE
resolver
uniprot_entry
Q3UD72_MOUSE
resolver
uniprot_sec
A2AE71
resolver
amino_acid_sequence
MESLHARLFPGLSINIQRSNGLIHPANISTVNVEKSCVSVEWIEGGTTKGKEIDIDDVAAINPELLQLLPLRPKDSLPLQENVTVPKQKRKSVNSKIPALKEGLRSRSTRMSTVSEVRIPAQENEMEVELPVPTNSRKQFAIPSHPRASCSTVTELPLLMVSEEAEEQAHSTRSTSSANPGNSVRRKSCIVKEMEKMKNKREEKRAQNSELRIKRAQEYDSSFPNWEFARMIKEFRVTMECSPLTVTDPIEEHRICVCVRKRPLNKQELAKKEIDVISVPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKSQNASKGIYAMASRDVFLLKNQPRYRNLNLEVYVTFFEIYNGKVFDLLNKKAKLRVLEDSRQQVQVVGLQEYLVTCADDVIKMINMGSACRTSGQTFANSNSSRSHACFQILLRTKGRLHGKFSLVDLAGNERGADTSSADRQTRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIAMISPGISSCEYTLNTLRYADRVKELSPHSGPSGEQPVQMETEVMEASSNGTSLTGNEEEELSSQMSSFNEAMTQIRELEERALEELREIIQQGPNWLELSEMTDQPDYDLETFVNKAESALTQQAKQAKHFSALREVIKALRLAMQLEEQASKQINSKKRHQ
uniprot
proteins
function
FUNCTION: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:14980225). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (By similarity). {ECO:0000250|UniProtKB:Q99661, ECO:0000269|PubMed:14980225}.
uniprot
proteins
mass_dalton
81085
uniprot
proteins
mutagenesis
MUTAGEN 293; /note="K->A: Loss of microtubule depolymerization activity."; /evidence="ECO:0000269|PubMed:14980225"; MUTAGEN 294; /note="V->A: Loss of microtubule depolymerization activity."; /evidence="ECO:0000269|PubMed:14980225"; MUTAGEN 295; /note="D->A: Loss of microtubule depolymerization activity."; /evidence="ECO:0000269|PubMed:14980225
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity. {ECO:0000250|UniProtKB:Q99661}.; PTM: Ubiquitinated. {ECO:0000250|UniProtKB:Q99661}.
uniprot
proteins
protein_family
Kinesin family
uniprot
proteins
protein_family
MCAK/KIF2 subfamily
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
14980225
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
721
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q99661}. Nucleus {ECO:0000250|UniProtKB:P70096}. Chromosome, centromere {ECO:0000250|UniProtKB:Q99661}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q99661}. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1. Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2A. {ECO:0000250|UniProtKB:P70096, ECO:0000250|UniProtKB:Q99661}.
uniprot
proteins