Mrgprd
entrez
211578
canonical
uniprot
Q91ZB8
canonical
ensembl
ENSMUSG00000051207
resolver
ensp
ENSMUSP00000063021
resolver
enst
ENSMUST00000062163
resolver
genesymbol
Mrgprd
resolver
genesymbol_syn
Gm499
resolver
genesymbol_syn
Mrgd
resolver
uniprot
Q5UCB4
resolver
uniprot_entry
MRGRD_MOUSE
resolver
uniprot_entry
Q5UCB4_MOUSE
resolver
amino_acid_sequence
MNSTLDSSPAPGLTISPTMDLVTWIYFSVTFLAMATCVGGMAGNSLVIWLLSCNGMQRSPFCVYVLNLAVADFLFLFCMASMLSLETGPLLIVNISAKIYEGMRRIKYFAYTAGLSLLTAISTQRCLSVLFPIWYKCHRPRHLSSVVSGALWALAFLMNFLASFFCVQFWHPNKHQCFKVDIVFNSLILGIFMPVMILTSTILFIRVRKNSLMQRRRPRRLYVVILTSILVFLTCSLPLGINWFLLYWVDVKRDVRLLYSCVSRFSSSLSSSANPVIYFLVGSQKSHRLQESLGAVLGRALRDEPEPEGRETPSTCTNDGV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that acts as a mediator of peripheral pain and itch sensations (PubMed:23446738, PubMed:29443552, PubMed:29792841, PubMed:30339496, PubMed:38147415). Activated by various ligands, such as beta-alanine, beta-aminoisobutyrate, angiotensin 1-7, alamandine and allantoin, causing a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:23446738, PubMed:27217404, PubMed:29443552, PubMed:29792841, PubMed:30339496, PubMed:36879552). MRGPRD is both coupled to G(q) and G(i) G proteins: G(q) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, while G(i) coupling mediates inhibition of adenylate cyclase activity (By similarity). MRGPRD is specifically expressed in neurons that innervate the epidermis and acts as a key mediator of skin stimuli, such as itch, pain and mechanical stimuli (PubMed:15629699, PubMed:33765440). Required to maintain skin homeostasis in response to irritant dermatitis by initiating a signaling that promotes glutamate release, inhibiting mast cell hyperresponsiveness and skin inflammation (PubMed:33765440). Required to prevent cardiomyocyte hypertrophy following activation by alamandine, a decarboxylation product of angiotensin 1-7 (PubMed:29443552, PubMed:30339496). Acts as a receptor for allantoin in dorsal root ganglion neurons, eliciting chronic itch (pruritus) (PubMed:36879552). {ECO:0000250|UniProtKB:Q8TDS7, ECO:0000269|PubMed:15629699, ECO:0000269|PubMed:23446738, ECO:0000269|PubMed:27217404, ECO:0000269|PubMed:29443552, ECO:0000269|PubMed:29792841, ECO:0000269|PubMed:30339496, ECO:0000269|PubMed:33765440, ECO:0000269|PubMed:36879552, ECO:0000269|PubMed:38147415}.
uniprot
proteins
mass_dalton
36126
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Mas subfamily
uniprot
proteins
pubmed
11551509
uniprot
proteins
pubmed
15037633
uniprot
proteins
pubmed
15629699
uniprot
proteins
pubmed
23446738
uniprot
proteins
pubmed
27217404
uniprot
proteins
pubmed
29443552
uniprot
proteins
pubmed
29792841
uniprot
proteins
pubmed
30339496
uniprot
proteins
pubmed
33765440
uniprot
proteins
pubmed
34901497
uniprot
proteins
pubmed
35979816
uniprot
proteins
pubmed
36879552
uniprot
proteins
pubmed
38147415
uniprot
proteins
sequence_length
321
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30339496}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine. {ECO:0000250|UniProtKB:Q8TDS7}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..49; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q8TDS7"; TRANSMEM 62..88; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q8TDS7"; TRANSMEM 98..127; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q8TDS7"; TRANSMEM 143..167; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q8TDS7"; TRANSMEM 179..205; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q8TDS7"; TRANSMEM 222..246; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q8TDS7"; TRANSMEM 257..281; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q8TDS7
uniprot
proteins