Bicdl1
entrez
75665
canonical
uniprot
A0JNT9
canonical
ensembl
ENSMUSG00000041609
resolver
ensp
ENSMUSP00000053547
resolver
genesymbol
Bicdl1
resolver
genesymbol_syn
Bicdr1
resolver
genesymbol_syn
Ccdc64
resolver
uniprot
Q8C9J5
resolver
uniprot
Q8CB56
resolver
uniprot
Q8R1D2
resolver
uniprot_entry
BICL1_MOUSE
resolver
uniprot_sec
Q8C9J5
resolver
uniprot_sec
Q8CB56
resolver
uniprot_sec
Q8R1D2
resolver
amino_acid_sequence
MSAFCLGLAGRASAPAEPDSACCMELPAGAGDAVRSPATAAALVSFPGGPGELELALEEELALLAAGERSSEPGEHPQAEPESPVEGHGPPLPPPPTQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELETDVKQLQDELERQQLHLREADREKTRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALKEDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSYRQLQGKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNDLKRLIQSIVDGVEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCKMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKEQSRPAAAAFPRGHGVGRGQEPSTADGKRLFSFFRKI
uniprot
proteins
function
FUNCTION: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:29420470, PubMed:33734450, PubMed:36071160). Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis. {ECO:0000269|PubMed:20360680, ECO:0000269|PubMed:29420470, ECO:0000269|PubMed:33734450, ECO:0000269|PubMed:36071160}.
uniprot
proteins
mass_dalton
65287
uniprot
proteins
mutagenesis
MUTAGEN 512; /note="K->M: Abolishes Rab6-binding."; /evidence="ECO:0000269|PubMed:20360680
uniprot
proteins
protein_family
BICDR family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20360680
uniprot
proteins
pubmed
29420470
uniprot
proteins
pubmed
33734450
uniprot
proteins
pubmed
36071160
uniprot
proteins
sequence_length
577
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305|PubMed:36071160}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20360680}. Note=Localizes around the centrosome.
uniprot
proteins