ENTPD4
entrez
9583
canonical
uniprot
Q9Y227
canonical
ensembl
ENSG00000197217
resolver
ensp
ENSP00000351520
resolver
ensp
ENSP00000408573
resolver
genesymbol
ENTPD4
resolver
genesymbol_syn
KIAA0392
resolver
genesymbol_syn
LALP70
resolver
genesymbol_syn
LYSAL1
resolver
hgnc
HGNC:14573
resolver
uniprot
D3DSS3
resolver
uniprot
O15092
resolver
uniprot_entry
ENTP4_HUMAN
resolver
uniprot_sec
D3DSS3
resolver
uniprot_sec
O15092
resolver
amino_acid_sequence
MGRIGISCLFPASWHFSISPVGCPRILNTNLRQIMVISVLAAAVSLLYFSVVIIRNKYGRLTRDKKFQRYLARVTDIEATDTNNPNVNYGIVVDCGSSGSRVFVYCWPRHNGNPHDLLDIRQMRDKNRKPVVMKIKPGISEFATSPEKVSDYISPLLNFAAEHVPRAKHKETPLYILCTAGMRILPESQQKAILEDLLTDIPVHFDFLFSDSHAEVISGKQEGVYAWIGINFVLGRFEHIEDDDEAVVEVNIPGSESSEAIVRKRTAGILDMGGVSTQIAYEVPKTVSFASSQQEEVAKNLLAEFNLGCDVHQTEHVYRVYVATFLGFGGNAARQRYEDRIFANTIQKNRLLGKQTGLTPDMPYLDPCLPLDIKDEIQQNGQTIYLRGTGDFDLCRETIQPFMNKTNETQTSLNGVYQPPIHFQNSEFYGFSEFYYCTEDVLRMGGDYNAAKFTKAAKDYCATKWSILRERFDRGLYASHADLHRLKYQCFKSAWMFEVFHRGFSFPVNYKSLKTALQVYDKEVQWTLGAILYRTRFLPLRDIQQEAFRASHTHWRGVSFVYNHYLFSGCFLVVLLAILLYLLRLRRIHRRTPRSSSAAALWMEEGLPAQNAPGTL
uniprot
proteins
ec_number
3.6.1.15
uniprot
proteins
ec_number
3.6.1.42
uniprot
proteins
ec_number
3.6.1.6
uniprot
proteins
function
FUNCTION: [Isoform 1]: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP. AMP, ADP, ATP and UMP are not substrates (PubMed:10858452, PubMed:9556635). Preferentially activated by Ca(2+) over Mg(2+) (PubMed:10858452). {ECO:0000269|PubMed:10858452, ECO:0000269|PubMed:9556635}.; FUNCTION: [Isoform 2]: Has a broad substrate specificity with the ability of cleaving all nucleotide di- and triphosphates with the exception of adenosine di- and triphosphate (ADP and ATP). Preferentially hydrolyzes CTP, UDP, CDP, GTP and GDP. Can use either Ca(2+) or Mg(2+) equally. {ECO:0000269|PubMed:10858452, ECO:0000269|PubMed:9556635}.
uniprot
proteins
mass_dalton
70255
uniprot
proteins
protein_family
GDA1/CD39 NTPase family
uniprot
proteins
pubmed
10393803
uniprot
proteins
pubmed
10858452
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
32767432
uniprot
proteins
pubmed
9205841
uniprot
proteins
pubmed
9556635
uniprot
proteins
sequence_length
616
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:10393803}; Multi-pass membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:10393803}; Multi-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus membrane {ECO:0000269|PubMed:9556635}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 560..580; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins