Cib2
entrez
300719
canonical
uniprot
Q568Z7
canonical
ensembl
ENSRNOG00000079672
resolver
ensembl
ENSRNOG00055030706
resolver
ensembl
ENSRNOG00060017853
resolver
ensembl
ENSRNOG00065017330
resolver
ensp
ENSRNOP00000101471
resolver
ensp
ENSRNOP00000109130
resolver
ensp
ENSRNOP00055044046
resolver
ensp
ENSRNOP00060024720
resolver
ensp
ENSRNOP00065022845
resolver
enst
ENSRNOT00000150232
resolver
enst
ENSRNOT00055053282
resolver
enst
ENSRNOT00060030568
resolver
enst
ENSRNOT00065028876
resolver
genesymbol
Cib2
resolver
uniprot_entry
CIB2_RAT
resolver
amino_acid_sequence
MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHARFYELAPNLVPMDYRKSPIVHVPMSLIIQMPELRENPFKERIVEAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEDEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI
uniprot
proteins
function
FUNCTION: Calcium- and integrin-binding protein that plays a role in intracellular calcium homeostasis (By similarity). Acts as an auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells (By similarity). Essential for mechanoelectrical transduction (MET) currents in auditory hair cells and thereby required for hearing (By similarity). Regulates the function of hair cell mechanotransduction by controlling the distribution of transmembrane channel-like proteins TMC1 and TMC2, and by regulating the function of the MET channels in hair cells (By similarity). Required for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea (By similarity). Critical for proper photoreceptor cell maintenance and function (By similarity). Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release (By similarity). {ECO:0000250|UniProtKB:O75838, ECO:0000250|UniProtKB:Q9Z309}.
uniprot
proteins
mass_dalton
21672
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28663585
uniprot
proteins
sequence_length
187
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Z309}. Cell projection, stereocilium {ECO:0000250|UniProtKB:O75838}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9Z309}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9Z309}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q9Z309}. Note=Colocalizes with ITGA7 at the myotendinous junctions (MTJ) and at the neuromuscular junctions (NMJ) (By similarity). Located mainly in stereocilia and at the apical surface of hair cells of the cochlea (By similarity). Localizes in the cuticular plate along and at the tip of the stereocilia of vestibular sensory hair cells (By similarity). {ECO:0000250|UniProtKB:O75838, ECO:0000250|UniProtKB:Q9Z309}.
uniprot
proteins