Elk4
entrez
13714
canonical
uniprot
P41158
canonical
ensembl
ENSMUSG00000026436
resolver
ensp
ENSMUSP00000027696
resolver
ensp
ENSMUSP00000083743
resolver
ensp
ENSMUSP00000272389
resolver
ensp
ENSMUSP00000272392
resolver
ensp
ENSMUSP00000272393
resolver
ensp
ENSMUSP00000272394
resolver
enst
ENSMUST00000027696
resolver
enst
ENSMUST00000086556
resolver
genesymbol
Elk4
resolver
genesymbol_syn
Sap1
resolver
uniprot
A6H693
resolver
uniprot_entry
ELK4_MOUSE
resolver
uniprot_sec
A6H693
resolver
amino_acid_sequence
MDSAITLWQFLLQLLQEPQNEHMICWTSNNGEFKLLQAEEVARLWGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKFVSYPEILKMDPLTVGRIEGDCEALNSIETSSSKDVEYGGKERPPQPGAKTSSRNDYIHSGLYSSFTLNSLNTSNKKLFKSIKIENPAEKLAEKKAQEPTPSVIKFVTTPAKKPPIEPVAAAFATSPSLSPSSEETIQALETLVSPTLPSLETPASISILATTFNPTPPVPSTPLPLKEPPRTPSPPLSSNPDIDTDIESVASQPMELPENLSLEPKNEDSALPEKDKTNNSSRSKKPKGLELTPALVVTGSDPSPLGILSPSLPTASLTPALFSQTPILLTPSPLLSSIHFWSTLSPFAPLSPARLQGANTLFQFPSVLNSHGPFTLSGLDGPSTPGPFSPDLQKT
uniprot
proteins
function
FUNCTION: Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
46826
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7958835
uniprot
proteins
sequence_length
430
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins