Gphn
entrez
64845
canonical
uniprot
Q03555
canonical
ensembl
ENSRNOG00000064630
resolver
ensembl
ENSRNOG00055018422
resolver
ensembl
ENSRNOG00055018485
resolver
ensembl
ENSRNOG00060026299
resolver
ensembl
ENSRNOG00060027041
resolver
ensembl
ENSRNOG00065017865
resolver
ensp
ENSRNOP00000082164
resolver
ensp
ENSRNOP00000087130
resolver
ensp
ENSRNOP00000088628
resolver
enst
ENSRNOT00000114358
resolver
enst
ENSRNOT00000118026
resolver
genesymbol
Gphn
resolver
genesymbol_syn
Gph
resolver
uniprot
A0A8I6A568
resolver
uniprot
A0A8I6A9T9
resolver
uniprot_entry
A0A8I6A568_RAT
resolver
uniprot_entry
A0A8I6A9T9_RAT
resolver
uniprot_entry
GEPH_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by copper and tungsten. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEKFPTFPFCGLQKGATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGVQCEEEEEEKKDSGVASTEDSSSSHITAAALAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKQIRRPDESKGVASRVGSLKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL
uniprot
proteins
ec_number
2.10.1.1
uniprot
proteins
ec_number
2.7.7.75
uniprot
proteins
function
FUNCTION: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (PubMed:8264797). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (By similarity). {ECO:0000250|UniProtKB:Q8BUV3, ECO:0000269|PubMed:8264797}.; FUNCTION: Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000269|PubMed:23163752, ECO:0000269|PubMed:9990024}.
uniprot
proteins
mass_dalton
83266
uniprot
proteins
mutagenesis
MUTAGEN 362; /note="F->A: Reduced GLRB binding."; /evidence="ECO:0000269|PubMed:16511563"; MUTAGEN 745..746; /note="PP->AA: Reduced GLRB binding."; /evidence="ECO:0000269|PubMed:16511563"; MUTAGEN 745; /note="P->A: Loss of GLRB binding."; /evidence="ECO:0000269|PubMed:16511563
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. {ECO:0000305|PubMed:9990024}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated.; PTM: Palmitoylated. Palmitoylation is stimulated by GABA type A receptors activity. Palmitoylation by ZDHHC12 regulates clustering at synapses. {ECO:0000250|UniProtKB:Q8BUV3}.
uniprot
proteins
protein_family
MoaB/Mog family; MoeA family
uniprot
proteins
pubmed
10900017
uniprot
proteins
pubmed
11083919
uniprot
proteins
pubmed
11325967
uniprot
proteins
pubmed
12684523
uniprot
proteins
pubmed
1319186
uniprot
proteins
pubmed
15201864
uniprot
proteins
pubmed
16511563
uniprot
proteins
pubmed
22270318
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23163752
uniprot
proteins
pubmed
25137389
uniprot
proteins
pubmed
25413248
uniprot
proteins
pubmed
25531214
uniprot
proteins
pubmed
27112598
uniprot
proteins
pubmed
8264797
uniprot
proteins
pubmed
9990024
uniprot
proteins
sequence_length
768
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:16511563}; Lipid-anchor {ECO:0000305|PubMed:16511563}; Cytoplasmic side {ECO:0000269|PubMed:16511563}. Cell membrane {ECO:0000269|PubMed:12684523}; Lipid-anchor {ECO:0000305|PubMed:12684523}; Cytoplasmic side {ECO:0000305|PubMed:12684523}. Cytoplasm, cytosol {ECO:0000269|PubMed:22270318}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16511563}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9NQX3}. Postsynaptic density {ECO:0000250|UniProtKB:Q8BUV3}. Note=Cytoplasmic face of glycinergic postsynaptic membranes (PubMed:16511563). Forms clusters at synapses (By similarity). {ECO:0000250|UniProtKB:Q8BUV3, ECO:0000269|PubMed:16511563}.
uniprot
proteins