Mcrip1
entrez
192173
canonical
uniprot
Q3UGS4
canonical
ensembl
ENSMUSG00000061111
resolver
ensp
ENSMUSP00000034913
resolver
ensp
ENSMUSP00000300262
resolver
enst
ENSMUST00000034913
resolver
genesymbol
Mcrip1
resolver
genesymbol_syn
Fam195b
resolver
uniprot
Q8QZS4
resolver
uniprot_entry
MCRI1_MOUSE
resolver
uniprot_sec
Q8QZS4
resolver
amino_acid_sequence
MTSSPVSRVVYNGKRNSSPRSPTNSSEIFTPAHEENVRFIYEAWQGVERDLRSQLSSGERCLVEEYVEKVPNPSLKTFKPIDLSDLKRRNTQDAKKS
uniprot
proteins
function
FUNCTION: The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition. {ECO:0000250|UniProtKB:C9JLW8}.
uniprot
proteins
mass_dalton
11101
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by MAPK3/1 (ERK1/2) regulates MCRIP1 binding to CTBP(s). {ECO:0000250|UniProtKB:C9JLW8}.
uniprot
proteins
protein_family
MCRIP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25728771
uniprot
proteins
sequence_length
97
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C9JLW8}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:C9JLW8}.
uniprot
proteins