HTR1F
entrez
3355
canonical
uniprot
P30939
canonical
ensembl
ENSG00000179097
resolver
ensp
ENSP00000322924
resolver
ensp
ENSP00000529033
resolver
enst
ENST00000319595
resolver
enst
ENST00000858974
resolver
genesymbol
HTR1F
resolver
genesymbol_syn
HTR1EL
resolver
hgnc
HGNC:5292
resolver
uniprot_entry
5HT1F_HUMAN
resolver
amino_acid_sequence
MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:21422162, PubMed:34239069, PubMed:8380639, PubMed:8384716). Also functions as a receptor for various alkaloids and psychoactive substances (PubMed:21422162, PubMed:8380639, PubMed:8384716). Receptor for lasmiditan, a drug for the treatment of acute migraine (PubMed:34239069). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:34239069). HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed:34239069, PubMed:35610220). {ECO:0000269|PubMed:21422162, ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:8380639, ECO:0000269|PubMed:8384716}.
uniprot
proteins
mass_dalton
41709
uniprot
proteins
mutagenesis
MUTAGEN 103; /note="D->A: Decreased binding to lasmiditan drug."; /evidence="ECO:0000269|PubMed:34239069"; MUTAGEN 104; /note="I->A: Decreased binding to lasmiditan drug."; /evidence="ECO:0000269|PubMed:34239069"; MUTAGEN 107; /note="C->A: Decreased binding to lasmiditan drug."; /evidence="ECO:0000269|PubMed:34239069"; MUTAGEN 108; /note="T->A: Decreased binding to lasmiditan drug."; /evidence="ECO:0000269|PubMed:34239069"; MUTAGEN 182; /note="T->A: Decreased binding to lasmiditan drug."; /evidence="ECO:0000269|PubMed:34239069"; MUTAGEN 306; /note="W->A: Decreased binding to lasmiditan drug."; /evidence="ECO:0000269|PubMed:34239069"; MUTAGEN 309; /note="F->A: Decreased binding to lasmiditan drug."; /evidence="ECO:0000269|PubMed:34239069"; MUTAGEN 310; /note="F->A: Decreased binding to lasmiditan drug."; /evidence="ECO:0000269|PubMed:34239069"; MUTAGEN 313; /note="E->S,A: Decreased binding to lasmiditan drug. Nearly abolished G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220"; MUTAGEN 337; /note="Y->A: Decreased binding to lasmiditan drug."; /evidence="ECO:0000269|PubMed:34239069
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
18476671
uniprot
proteins
pubmed
20945968
uniprot
proteins
pubmed
21422162
uniprot
proteins
pubmed
34239069
uniprot
proteins
pubmed
35610220
uniprot
proteins
pubmed
8380639
uniprot
proteins
pubmed
8384716
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21422162, ECO:0000269|PubMed:8380639, ECO:0000269|PubMed:8384716}; Multi-pass membrane protein {ECO:0000269|PubMed:8380639, ECO:0000269|PubMed:8384716}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..49; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:34239069, ECO:0007744|PDB:7EXD"; TRANSMEM 60..81; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:34239069, ECO:0007744|PDB:7EXD"; TRANSMEM 97..119; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:34239069, ECO:0007744|PDB:7EXD"; TRANSMEM 140..159; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:34239069, ECO:0007744|PDB:7EXD"; TRANSMEM 179..202; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:34239069, ECO:0007744|PDB:7EXD"; TRANSMEM 292..315; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:34239069, ECO:0007744|PDB:7EXD"; TRANSMEM 328..350; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:34239069, ECO:0007744|PDB:7EXD
uniprot
proteins