Dennd2b
entrez
76954
canonical
uniprot
Q924W7
canonical
ensembl
ENSMUSG00000031024
resolver
ensp
ENSMUSP00000077067
resolver
ensp
ENSMUSP00000078264
resolver
ensp
ENSMUSP00000130119
resolver
ensp
ENSMUSP00000168709
resolver
genesymbol
Dennd2b
resolver
genesymbol_syn
Denn2b
resolver
genesymbol_syn
St5
resolver
uniprot
Q05BD9
resolver
uniprot
Q78H54
resolver
uniprot
Q8K2P3
resolver
uniprot
Q924W8
resolver
uniprot_entry
DEN2B_MOUSE
resolver
uniprot_sec
Q05BD9
resolver
uniprot_sec
Q78H54
resolver
uniprot_sec
Q8K2P3
resolver
uniprot_sec
Q924W8
resolver
amino_acid_sequence
MTMTANKNSSITHGTGGTKAPRETLSRSQSVSPPPVLYPPRSPIYPLSDSETSACRYPSHSKSQVLLKDRHSRNPSLLGQDPSPETSPPICTLKATSFSYLDRTPSLRKREDQKETVQGAVQDVEGVAACLPLAQSTPFLGAGSRSVLLSCTGTRAHSLGIREKISAWEGRREASPRMSLCGEKREGPGSEWSVSEGCPSVGCPSVVPSPCSSEKTFDFKGLRRMSRTFSECSYPETEEEAEALPGRDSLYRLEKRPGRTEPSALLRGHGIRKESSAVLSRIQKIEQALKEQPGRGLPQLPSSCYSVDQGRRKTGTLGTLEEPTGTASVSPSSRAGGVAGVAGEAGPPLDREGSASMKSETPGNSSSPQLLPPKSSPDPAVNPVPKPKRTFEYEADKNPKTKPSNGLPPSPTPAAPPPLPSTPAPPVTRRPKKDMRGHRKSQNRKSFEFEDASSLQSLYPSSPTENGTESQPKFGSKSTLEENAYEDIVGGLPKENPYEDVDLKNRRAGRKSQQLSENSLDSLHRMWSPQDRKYNHPPMQLSLKSNSQSLRSGNWSERKSHRLPRLPKRHSHDDMMLLAQLSLPSSPSSLNEDSLSTTSELLSSRRSRRIPKLVQRINSIYNAKRGKKRLKKLSMSSLETASLRDENSESESDSDDRFKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKSELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTHSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN
uniprot
proteins
function
FUNCTION: [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane. {ECO:0000250|UniProtKB:P78524}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000250|UniProtKB:P78524}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1. May alter cell morphology and cell growth. {ECO:0000250|UniProtKB:P78524}.
uniprot
proteins
mass_dalton
126861
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation decreases ITSN1 binding. {ECO:0000250|UniProtKB:P78524}.
uniprot
proteins
pubmed
11528127
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P78524}. Cell membrane {ECO:0000250|UniProtKB:P78524}. Recycling endosome {ECO:0000250|UniProtKB:P78524}. Note=Colocalizes with RAB13 and ITSN1 at cytoplasmic vesicles that are most likely recycling endosomes. Colocalizes with the cortical actin cytoskeleton. {ECO:0000250|UniProtKB:P78524}.
uniprot
proteins