Dclre1c
entrez
227525
canonical
uniprot
Q8K4J0
canonical
ensembl
ENSMUSG00000026648
resolver
ensp
ENSMUSP00000054300
resolver
ensp
ENSMUSP00000098031
resolver
ensp
ENSMUSP00000100053
resolver
ensp
ENSMUSP00000110718
resolver
ensp
ENSMUSP00000237076
resolver
ensp
ENSMUSP00000237088
resolver
ensp
ENSMUSP00000340008
resolver
enst
ENSMUST00000100463
resolver
genesymbol
Dclre1c
resolver
genesymbol_syn
Art
resolver
genesymbol_syn
Snm1l
resolver
uniprot
A2AJG6
resolver
uniprot
A2AJG7
resolver
uniprot
A2AJG8
resolver
uniprot
F6WB21
resolver
uniprot
Q32MX8
resolver
uniprot
Q8BG72
resolver
uniprot
Q8BTT1
resolver
uniprot_entry
DCR1C_MOUSE
resolver
uniprot_entry
F6WB21_MOUSE
resolver
uniprot_entry
Q32MX8_MOUSE
resolver
uniprot_sec
A2AJG6
resolver
uniprot_sec
A2AJG7
resolver
uniprot_sec
A2AJG8
resolver
uniprot_sec
Q8BG72
resolver
uniprot_sec
Q8BTT1
resolver
amino_acid_sequence
MSSFQGQMAEYPTISIDRFDRENLKARAYFLSHCHKDHMKGLRAPSLKRRLECSLKVFLYCSPVTKELLLTSPKYRFWENRIITIEIETPTQISLVDEASGEKEEVVVTLLPAGHCPGSVMFLFQGSNGTVLYTGDFRLAKGEASRMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREQCLRGILELVRSWVTRSPHHVVWLNCKAAYGYEYLFTNLSEELGVQVHVDKLDMFKNMPDILHHLTTDRNTQIHACRHPKAEECFQWNKLPCGITSQNKTALHTISIKPSTMWFGERTRKTNVIVRTGESSYRACFSFHSSFSEIKDFLSYICPVNVYPNVIPVGLTVDKVMDVLKPLCRSPQSVEPKYKPLGKLKRARTIHLDSEEDDDLFDDPLPTPLRHKVPYQLTLQPELFSMKALPLDQPELRQSPGGCKAESVWSPSLANFIDCEESNSDSGEELETPPPSLQGGLGPSTLVQQNADPDVDIPQWEVFFKRRDEITGECLEHLPSSIETGGSQSPKLCSDSPKLCSDSPKLCSDSDGDSTHISSQNSSQSTHITDQGSQGWDSQCDTVLLSSQEKSGGDSTSLNKGAYKPKLKESISASQIEQDALCPQDTHCDLKSRAEVNGAPCLVELDTLSGRKSPPEKTLLSSTRADSQSSSDFEIPSTPEAELPTPEHLQCLYRKLATGQSIVVEKRKCSLLDS
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein likely exhibits single-strand specific 5'-3' exonuclease activity in isolation, and may acquire endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity may be required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ. {ECO:0000269|PubMed:12504013, ECO:0000269|PubMed:12615897, ECO:0000269|PubMed:15699179}.
uniprot
proteins
mass_dalton
78834
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on undefined residues by PRKDC may stimulate endonucleolytic activity on 5' and 3' hairpins and overhangs. PRKDC must remain present, even after phosphorylation, for efficient hairpin opening. Also phosphorylated by ATM in response to ionizing radiation (IR) and by ATR in response to ultraviolet (UV) radiation (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
DNA repair metallo-beta-lactamase (DRMBL) family
uniprot
proteins
pubmed
12177301
uniprot
proteins
pubmed
12504013
uniprot
proteins
pubmed
12615897
uniprot
proteins
pubmed
15699179
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
705
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins