ADCY9
entrez
115
canonical
uniprot
O60503
canonical
ensembl
ENSG00000162104
resolver
ensp
ENSP00000294016
resolver
ensp
ENSP00000538311
resolver
ensp
ENSP00000606525
resolver
enst
ENST00000294016
resolver
enst
ENST00000868252
resolver
enst
ENST00000936466
resolver
genesymbol
ADCY9
resolver
genesymbol_syn
KIAA0520
resolver
hgnc
HGNC:240
resolver
uniprot
A7E2V5
resolver
uniprot
A7E2X2
resolver
uniprot
D3DUD1
resolver
uniprot
O60273
resolver
uniprot
Q4ZHT9
resolver
uniprot
Q4ZIR5
resolver
uniprot
Q9BWT4
resolver
uniprot
Q9UGP2
resolver
uniprot_entry
ADCY9_HUMAN
resolver
uniprot_sec
A7E2V5
resolver
uniprot_sec
A7E2X2
resolver
uniprot_sec
D3DUD1
resolver
uniprot_sec
O60273
resolver
uniprot_sec
Q4ZHT9
resolver
uniprot_sec
Q4ZIR5
resolver
uniprot_sec
Q9BWT4
resolver
uniprot_sec
Q9UGP2
resolver
activity_regulation
ACTIVITY REGULATION: Insensitive to calcium/calmodulin, forskolin and somatostatin. Stimulated by beta-adrenergic receptor activation (PubMed:9628827). Activity is down-regulated by calcium/calcineurin (PubMed:10987815). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:9628827}.
uniprot
proteins
amino_acid_sequence
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEERGRFGKAIEKDDCDETGIEEANELTKLNVSKSV
uniprot
proteins
ec_number
4.6.1.1
uniprot
proteins
function
FUNCTION: Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}.
uniprot
proteins
mass_dalton
150701
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
10987815
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12972952
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15879435
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9628581
uniprot
proteins
pubmed
9628827
uniprot
proteins
sequence_length
1353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:9628827}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 216..235; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 242..259; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 281..301; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 787..807; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 819..839; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 868..888; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 892..912; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 921..941; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 976..996; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins