ANAPC10
entrez
10393
canonical
uniprot
Q9UM13
canonical
ensembl
ENSG00000164162
resolver
ensp
ENSP00000310071
resolver
ensp
ENSP00000403891
resolver
ensp
ENSP00000423995
resolver
ensp
ENSP00000425459
resolver
ensp
ENSP00000478501
resolver
ensp
ENSP00000547506
resolver
ensp
ENSP00000547507
resolver
ensp
ENSP00000547508
resolver
ensp
ENSP00000547509
resolver
ensp
ENSP00000584573
resolver
ensp
ENSP00000584574
resolver
ensp
ENSP00000584576
resolver
ensp
ENSP00000584577
resolver
ensp
ENSP00000584578
resolver
ensp
ENSP00000584580
resolver
ensp
ENSP00000584581
resolver
ensp
ENSP00000584582
resolver
ensp
ENSP00000654997
resolver
ensp
ENSP00000654999
resolver
ensp
ENSP00000719978
resolver
ensp
ENSP00000719981
resolver
ensp
ENSP00000754496
resolver
ensp
ENSP00000754500
resolver
enst
ENST00000309439
resolver
enst
ENST00000451299
resolver
enst
ENST00000507656
resolver
enst
ENST00000512680
resolver
enst
ENST00000613466
resolver
enst
ENST00000877447
resolver
enst
ENST00000877448
resolver
enst
ENST00000877449
resolver
enst
ENST00000877450
resolver
enst
ENST00000914514
resolver
enst
ENST00000914515
resolver
enst
ENST00000914517
resolver
enst
ENST00000914518
resolver
enst
ENST00000914519
resolver
enst
ENST00000914521
resolver
enst
ENST00000914522
resolver
enst
ENST00000914523
resolver
genesymbol
ANAPC10
resolver
genesymbol_syn
APC10
resolver
hgnc
HGNC:24077
resolver
uniprot
D3DNZ7
resolver
uniprot
D6RD74
resolver
uniprot
Q2V500
resolver
uniprot
Q9UG51
resolver
uniprot
Q9Y5R0
resolver
uniprot_entry
APC10_HUMAN
resolver
uniprot_entry
D6RD74_HUMAN
resolver
uniprot_sec
D3DNZ7
resolver
uniprot_sec
Q2V500
resolver
uniprot_sec
Q9UG51
resolver
uniprot_sec
Q9Y5R0
resolver
amino_acid_sequence
MTTPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQPHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWIHVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIGKFPRCTTIDFMMYRSIR
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:18485873, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (PubMed:27509861). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:27120157, ECO:0000269|PubMed:27509861, ECO:0000269|PubMed:29033132}.
uniprot
proteins
mass_dalton
21252
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
uniprot
proteins
protein_family
APC10 family
uniprot
proteins
pubmed
10318877
uniprot
proteins
pubmed
10498862
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11524682
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16364912
uniprot
proteins
pubmed
18485873
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25043029
uniprot
proteins
pubmed
26083744
uniprot
proteins
pubmed
27120157
uniprot
proteins
pubmed
27509861
uniprot
proteins
pubmed
29033132
uniprot
proteins
pubmed
34595750
uniprot
proteins
sequence_length
185
uniprot
proteins