MAK
entrez
4117
canonical
uniprot
P20794
canonical
ensembl
ENSG00000111837
resolver
ensp
ENSP00000346484
resolver
ensp
ENSP00000442221
resolver
ensp
ENSP00000442250
resolver
ensp
ENSP00000476067
resolver
ensp
ENSP00000502045
resolver
ensp
ENSP00000502542
resolver
enst
ENST00000538030
resolver
enst
ENST00000675026
resolver
enst
ENST00000676116
resolver
genesymbol
MAK
resolver
hgnc
HGNC:6816
resolver
uniprot
A0A140VK28
resolver
uniprot
A0A6Q8PG01
resolver
uniprot
A0A6Q8PH30
resolver
uniprot
F1T0K6
resolver
uniprot
F6W613
resolver
uniprot
F8VBW7
resolver
uniprot
G1FL29
resolver
uniprot
Q547D0
resolver
uniprot
Q8IXN4
resolver
uniprot
Q9NUH7
resolver
uniprot_entry
A0A140VK28_HUMAN
resolver
uniprot_entry
A0A6Q8PG01_HUMAN
resolver
uniprot_entry
A0A6Q8PH30_HUMAN
resolver
uniprot_entry
F6W613_HUMAN
resolver
uniprot_entry
F8VBW7_HUMAN
resolver
uniprot_entry
MAK_HUMAN
resolver
uniprot_entry
Q8IXN4_HUMAN
resolver
uniprot_sec
F1T0K6
resolver
uniprot_sec
G1FL29
resolver
uniprot_sec
Q547D0
resolver
uniprot_sec
Q9NUH7
resolver
amino_acid_sequence
MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLESKQSLNKQLQPLESKPSLVEVEPKPLPDIIDQVVGQPQPKTSQQPLQPIQPPQNLSVQQPPKQQSQEKPPQTLFPSIVKNMPTKPNGTLSHKSGRRRWGQTIFKSGDSWEELEDYDFGASHSKKPSMGVFKEKRKKDSPFRLPEPVPSGSNHSTGENKSLPAVTSLKSDSELSTAPTSKQYYLKQSRYLPGVNPKKVSLIASGKEINPHTWSNQLFPKSLGPVGAELAFKRSNAGNLGSYATYNQSGYIPSFLKKEVQSAGQRIHLAPLNATASEYTWNTKTGRGQFSGRTYNPTAKNLNIVNRAQPIPSVHGRTDWVAKYGGHR
uniprot
proteins
disease_involvement
DISEASE: Retinitis pigmentosa 62 (RP62) [MIM:614181]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. {ECO:0000269|PubMed:21825139, ECO:0000269|PubMed:21835304}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. {ECO:0000250, ECO:0000269|PubMed:12084720, ECO:0000269|PubMed:16951154, ECO:0000269|PubMed:21986944}.
uniprot
proteins
mass_dalton
70581
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="K->R: Abolishes autophosphorylation."; /evidence="ECO:0000269|PubMed:12084720"; MUTAGEN 157; /note="T->A: Abolishes autophosphorylation and impairs kinase activity."; /evidence="ECO:0000269|PubMed:21986944"; MUTAGEN 159; /note="Y->F: Abolishes autophosphorylation and impairs kinase activity."; /evidence="ECO:0000269|PubMed:21986944
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Phosphorylated on serine and threonine residues. {ECO:0000269|PubMed:12084720, ECO:0000269|PubMed:21986944}.
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
12084720
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
16951154
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
21697133
uniprot
proteins
pubmed
21825139
uniprot
proteins
pubmed
2183027
uniprot
proteins
pubmed
21835304
uniprot
proteins
pubmed
21986944
uniprot
proteins
sequence_length
623
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Photoreceptor inner segment. Note=Localized in both the connecting cilia and the outer segment axonemes (By similarity). Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase. {ECO:0000250}.
uniprot
proteins