Clstn2
entrez
64085
canonical
uniprot
Q9ER65
canonical
ensembl
ENSMUSG00000032452
resolver
ensp
ENSMUSP00000035027
resolver
ensp
ENSMUSP00000124081
resolver
genesymbol
Clstn2
resolver
genesymbol_syn
Cs2
resolver
genesymbol_syn
Cstn2
resolver
genesymbol_syn
Kiaa4134
resolver
uniprot
Q5DTM0
resolver
uniprot
Q6P565
resolver
uniprot
Q8C858
resolver
uniprot_entry
CSTN2_MOUSE
resolver
uniprot_sec
Q5DTM0
resolver
uniprot_sec
Q6P565
resolver
uniprot_sec
Q8C858
resolver
amino_acid_sequence
MLPGRLCLVPLLLALGVGSGGGSGDGGDSRRRRLLVAKVNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPREAAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAIVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGSGSMPLFPSIHLETCDGAVSSLQVTAELQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSSEMIFKFDGRQGAKIPDGIVPKNLTDQFTITMWMKHGPSPGVRAEKETILCNSDKTEMNRHHYALYVHNCRLVFLLRKDFDQADTFRPAEFHWKLDQICDKEWHYYVINVEFPVVTLYMDGATYEPYLVTNDWPIHPSHIAMQLTVGACWQGGEVAKPRFAQFFHGSLASLTIRPGKMESQKVISCLQACKEGLDINSLESLGRGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRRLRLSSKVQCFGEDVCISIPDVDAYIMVLQAIEPQITLQGTERFWRPAAQFESARGVTLFPDIKIVSTFAKTEASGDMRATGTAPKSAVLEEMLHNLDFCDILVLGGDLDPRQECLELNHSELHQRHLDATNSTAGYSIYGVGSMNRYEQVLHHLRYRNWHPTSLETRRFRIKCSELNGRYTSNEFNLEVSVLHEVRVSDKEHVNHLIVQPPFLQSVHHPETRSSIQRSSVVPSIATVVIIISVCMLVFVVAMGVYRVRIAHQHFIQETEAAKEAEMDWDDSALTITVNPMEKHEGPGNGEDETTEVEEEEEAEEGSSSSSSGSDDSEEEEEEGMGRVRHGQSGTSSQSPERSTWNTAGVINIWK
uniprot
proteins
function
FUNCTION: Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory (PubMed:24613359, PubMed:26171716, PubMed:31529526). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). {ECO:0000250|UniProtKB:Q99JH7, ECO:0000269|PubMed:24613359, ECO:0000269|PubMed:26171716, ECO:0000269|PubMed:31529526}.
uniprot
proteins
mass_dalton
107887
uniprot
proteins
post_translational_modification
PTM: Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by gamma-secretase within the transmembrane domain releases the beta-Alc-gamma chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1. {ECO:0000250|UniProtKB:Q9H4D0}.
uniprot
proteins
protein_family
Calsyntenin family
uniprot
proteins
pubmed
12498782
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24613359
uniprot
proteins
pubmed
26171716
uniprot
proteins
pubmed
28647593
uniprot
proteins
pubmed
31529526
uniprot
proteins
pubmed
35279170
uniprot
proteins
sequence_length
966
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:12498782, ECO:0000269|PubMed:24613359}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12498782}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:12498782}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:12498782}. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. {ECO:0000269|PubMed:12498782}.
uniprot
proteins
transmembrane_region
TRANSMEM 836..856; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins