CWC22
entrez
57703
canonical
uniprot
Q9HCG8
canonical
ensembl
ENSG00000163510
resolver
ensp
ENSP00000384159
resolver
ensp
ENSP00000387006
resolver
ensp
ENSP00000588133
resolver
ensp
ENSP00000783927
resolver
enst
ENST00000410053
resolver
enst
ENST00000918074
resolver
genesymbol
CWC22
resolver
genesymbol_syn
KIAA1604
resolver
genesymbol_syn
NCM
resolver
hgnc
HGNC:29322
resolver
uniprot
Q05DC2
resolver
uniprot
Q4G135
resolver
uniprot
Q52LF0
resolver
uniprot
Q6PEX2
resolver
uniprot
Q7Z6I0
resolver
uniprot
Q9H5L3
resolver
uniprot
Q9H6Q6
resolver
uniprot_entry
CWC22_HUMAN
resolver
uniprot_sec
Q05DC2
resolver
uniprot_sec
Q4G135
resolver
uniprot_sec
Q52LF0
resolver
uniprot_sec
Q6PEX2
resolver
uniprot_sec
Q7Z6I0
resolver
uniprot_sec
Q9H5L3
resolver
uniprot_sec
Q9H6Q6
resolver
amino_acid_sequence
MKSSVAQIKPSSGHDRRENLNSYQRNSSPEDRYEEQERSPRDRDYFDYSRSDYEHSRRGRSYDSSMESRNRDREKRRERERDTDRKRSRKSPSPGRRNPETSVTQSSSAQDEPATKKKKDELDPLLTRTGGAYIPPAKLRMMQEQITDKNSLAYQRMSWEALKKSINGLINKVNISNISIIIQELLQENIVRGRGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNFRKGYRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGFLKECGLKLTQVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFKDHPIILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKYKAIKKEILDEGDTDSNTDQDAGSSEEDEEEEEEEGEEDEEGQKVTIHDKTEINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFPESQTKELCNMILDCCAQQRTYEKFFGLLAGRFCMLKKEYMESFEGIFKEQYDTIHRLETNKLRNVAKMFAHLLYTDSLPWSVLECIKLSEETTTSSSRIFVKIFFQELCEYMGLPKLNARLKDETLQPFFEGLLPRDNPRNTRFAINFFTSIGLGGLTDELREHLKNTPKVIVAQKPDVEQNKSSPSSSSSASSSSESDSSDSDSDSSDSSSESSSEESDSSSISSHSSASANDVRKKGHGKTRSKEVDKLIRNQQTNDRKQKERRQEHGHQETRTERERRSEKHRDQNSSGSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKKRGERRNSFSENEKHTHRIKDSENFRRKDRSKSKEMNRKHSGSRSDEDRYQNGAERRWEKSSRYSEQSRESKKNQDRRREKSPAKQK
uniprot
proteins
function
FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:12226669, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12226669, ECO:0000269|PubMed:22959432, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:23236153, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}.
uniprot
proteins
mass_dalton
105466
uniprot
proteins
mutagenesis
MUTAGEN 168; /note="G->Y: No effect on EIF4A3 incorporation into EJCs."; /evidence="ECO:0000269|PubMed:23236153"; MUTAGEN 171..174; /note="NKVN->AAVA: Loss of EIF4A3-binding."; MUTAGEN 171..172; /note="NK->DE: Loss of EIF4A3-binding."; /evidence="ECO:0000269|PubMed:22959432"; MUTAGEN 331; /note="R->A: Decreased EIF4A3-binding; when associated with A-334."; /evidence="ECO:0000269|PubMed:23236153"; MUTAGEN 334; /note="Y->A: Decreased EIF4A3-binding; when associated with A-331."; /evidence="ECO:0000269|PubMed:23236153
uniprot
proteins
protein_family
CWC22 family
uniprot
proteins
pubmed
10997877
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
12226669
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22959432
uniprot
proteins
pubmed
22961380
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23236153
uniprot
proteins
pubmed
24218557
uniprot
proteins
pubmed
28076346
uniprot
proteins
pubmed
28502770
uniprot
proteins
pubmed
29301961
uniprot
proteins
pubmed
29360106
uniprot
proteins
pubmed
33509932
uniprot
proteins
sequence_length
908
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106}. Nucleus speckle {ECO:0000269|PubMed:22961380}. Note=Concentrates around speckles, which are sites of pre-mRNA synthesis and processing, where it colocalizes with EJC core proteins. {ECO:0000269|PubMed:22961380}.
uniprot
proteins