Cdk11b
entrez
12537
canonical
uniprot
P24788
canonical
ensembl
ENSMUSG00000029062
resolver
ensp
ENSMUSP00000070527
resolver
ensp
ENSMUSP00000101223
resolver
ensp
ENSMUSP00000101225
resolver
enst
ENSMUST00000105598
resolver
genesymbol
Cdk11b
resolver
genesymbol_syn
Cdc2l1
resolver
genesymbol_syn
Cdk11
resolver
uniprot
A2A9P6
resolver
uniprot
Q3UI03
resolver
uniprot
Q61399
resolver
uniprot
Q7TST4
resolver
uniprot
Q8BP53
resolver
uniprot_entry
A2A9P6_MOUSE
resolver
uniprot_entry
CD11B_MOUSE
resolver
uniprot_sec
Q3UI03
resolver
uniprot_sec
Q61399
resolver
uniprot_sec
Q7TST4
resolver
uniprot_sec
Q8BP53
resolver
activity_regulation
ACTIVITY REGULATION: Phosphorylated and activated by CDK7 in the CDK-activating kinase (CAK) complex, and reciprocally phosphorylating its activating kinase CDK7 (By similarity). CDK11 is specifically inhibited by the anticancer agent OTS964 (By similarity). {ECO:0000250|UniProtKB:P06493, ECO:0000250|UniProtKB:P21127}.
uniprot
proteins
amino_acid_sequence
MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKLREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREEYSDKGKVGHWSRSPLRPPRERFEMGDNRKPVKEEKVEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEEETGSNSEEASEQSAEEVSDEEMSEDEDRENENHILVVPESRFDRDSGDSEEGEEEVGEGTPQSSAPTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMTFSEYPYNNLRKRFGALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
uniprot
proteins
ec_number
2.7.11.22
uniprot
proteins
ec_number
2.7.11.23
uniprot
proteins
function
FUNCTION: Cyclin-dependent protein kinase that acts as a regulator of transcription and pre-mRNA splicing (By similarity). Acts as a key regulator of pre-mRNA splicing by mediating phosphorylation of SF3B1, enabling the association between SF3B1 and U5 and U6 snRNAs in the activated spliceosome, thereby promoting spliceosome assembly (By similarity). Also acts as a regulator of transcription by phosphorylating 'Ser-2' of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (By similarity). Involved in replication-dependent transcription of histone genes: binds to histone genes and phosphorylates POLR2A at 'Ser-2' of the CTD to specifically control transcriptional elongation of histones and recruitment of 3'-end processing factors (By similarity). Part of a transcription checkpoint upstream of CDK9, which regulates promoter-proximal pausing by RNA polymerase II, a transcription halt following transcription initiation, but prior to elongation (By similarity). Probably regulates promoter-proximal pausing by mediating phosphorylation of POLR2A at 'Ser-2' of the CTD (By similarity). Activated by the CDK-activating kinase (CAK) complex consisting of CDK7, cyclin-H/CCNH and MAT1, which is a master regulator of CDK activity (By similarity). {ECO:0000250|UniProtKB:P21127}.; FUNCTION: [Isoform 1]: Isoform expressed in a non-cell cycle-dependent manner. {ECO:0000250|UniProtKB:P21127}.; FUNCTION: [Isoform 2]: Isoform specifically expressed during the G2-M phases of the cell cycle. Phosphorylates 'Ser-2' of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A. Promotes centromeric transcription to maintain centromeric cohesion during mitosis. {ECO:0000250|UniProtKB:P21127}.
uniprot
proteins
mass_dalton
91513
uniprot
proteins
post_translational_modification
PTM: [Isoform 1]: During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain. {ECO:0000250|UniProtKB:P21127}.; PTM: Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated. {ECO:0000250|UniProtKB:P21127}.
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15060143
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
2069872
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7528743
uniprot
proteins
sequence_length
784
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15060143}. Chromosome {ECO:0000250|UniProtKB:P21127}. Cytoplasm {ECO:0000250|UniProtKB:P21127}. Note=Localizes to transcription start site (TSS) proximal regions. {ECO:0000250|UniProtKB:P21127}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:P21127}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000250|UniProtKB:P21127}. Chromosome, centromere {ECO:0000250|UniProtKB:P21127}.
uniprot
proteins