SLC22A3
entrez
6581
canonical
uniprot
O75751
canonical
ensembl
ENSG00000146477
resolver
ensp
ENSP00000275300
resolver
ensp
ENSP00000777064
resolver
ensp
ENSP00000790022
resolver
ensp
ENSP00000791966
resolver
enst
ENST00000275300
resolver
genesymbol
SLC22A3
resolver
genesymbol_syn
EMTH
resolver
genesymbol_syn
OCT3
resolver
hgnc
HGNC:10967
resolver
uniprot
Q5SYN6
resolver
uniprot
Q9UP02
resolver
uniprot_entry
S22A3_HUMAN
resolver
uniprot_sec
Q5SYN6
resolver
uniprot_sec
Q9UP02
resolver
amino_acid_sequence
MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAPLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHSCKCGRNKKTPVSRSHL
uniprot
proteins
function
FUNCTION: Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10196521, PubMed:10966924, PubMed:12538837, PubMed:17460754, PubMed:20858707). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:10966924). Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter (PubMed:12538837). Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain (PubMed:10196521, PubMed:16581093, PubMed:20858707). Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency (PubMed:17460754). May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow (PubMed:10966924). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). Mediates the transport of polyamine spermidine and putrescine (By similarity). Mediates the bidirectional transport of polyamine agmatine (PubMed:12538837). Also transports guanidine (PubMed:10966924). Mediates the transport of choline (PubMed:40972734). May mediate intracellular transport of organic cations due to its localization on endomembranes, thereby contributing to amine metabolism and intracellular signaling (By similarity). {ECO:0000250|UniProtKB:O88446, ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924, ECO:0000269|PubMed:12538837, ECO:0000269|PubMed:16581093, ECO:0000269|PubMed:17460754, ECO:0000269|PubMed:20858707, ECO:0000269|PubMed:40972734, ECO:0000305|PubMed:35307651}.
uniprot
proteins
mass_dalton
61280
uniprot
proteins
mutagenesis
MUTAGEN 289; /note="P->A: Decreased TEA uptake."; /evidence="ECO:0000269|PubMed:26979622"; MUTAGEN 363; /note="V->F: Decreased TEA uptake."; /evidence="ECO:0000269|PubMed:26979622"; MUTAGEN 380; /note="Y->F: Decreased TEA uptake."; /evidence="ECO:0000269|PubMed:26979622
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
10196521
uniprot
proteins
pubmed
10966924
uniprot
proteins
pubmed
12538837
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15817714
uniprot
proteins
pubmed
16263091
uniprot
proteins
pubmed
16581093
uniprot
proteins
pubmed
16914559
uniprot
proteins
pubmed
17460754
uniprot
proteins
pubmed
20858707
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
26979622
uniprot
proteins
pubmed
35307651
uniprot
proteins
pubmed
40972734
uniprot
proteins
pubmed
9933568
uniprot
proteins
sequence_length
556
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15817714, ECO:0000269|PubMed:20858707}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:15817714, ECO:0000269|PubMed:16263091}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:15817714}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000250|UniProtKB:O88446}. Endomembrane system {ECO:0000250|UniProtKB:O88446}. Nucleus membrane {ECO:0000250|UniProtKB:O88446}. Nucleus outer membrane {ECO:0000250|UniProtKB:O88446}. Note=Localized to the apical/brush border membrane of enterocytes (PubMed:16263091). Localized to the luminal/apical membrane of ciliated epithelial cells in bronchi (PubMed:15817714). Localized to the basolateral membrane of intermediate cells in bronchi (PubMed:15817714). Localized to the entire plasma membrane of basal cells in bronchi (PubMed:15817714). {ECO:0000269|PubMed:15817714, ECO:0000269|PubMed:16263091}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 182..202; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 381..401; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 468..488; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 498..518; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins