Q63661
uniprot
Q63661
canonical
amino_acid_sequence
MRGPHGVSWRVPWLCLSCLCSCLLLLPVNTSTTSAPKTSTALPSSTNPSQMTSQVSNPTASSYRMTKNTGQASPMVTSSSITTLPQSQHTGSMKTTRNPQTTGTTEVTTTLSASSSDQVQVETTSQTTLSPDTTTTSHAPRESSSPPSTSVILTTTASTEGTSGDTGHTMAVTTQGSTPATTEISVTPSTQKMSPVSTFSTSTQEITTLSQSQHTGGMKTTRNPQTTGTTEVTTTLSASSSDHPTSSPESTPGNTAPRTTETSTTTTTKVLMTSLQQKLPTGSTLGTSTQELTTLPQSQHTGIMKTTSRTQTTTPTEVTTRTLSASSSDHRQAETSSQTTLSPDTTTTSHAPRESSPPSTSVILTHGHREGTSGDTGHTMAVTTQGSTPATTEISVTPSTQKMSPVSTFSTSTQEITTLSQSQHTGGMKTTRNPQRTTPTEVTTSTLSASSSDQVQVETTSRATLSPDTTTTSHAPSVSSSSPSPPSTEGTSVDTGLTTAVTTQDSTPATTQGSLTSSSQTLSTVSPLSTSTQETSTQELTSSQSQHTGSMKTTHNPQTTRNTEVTTTLSASSSDQVQVETTSQTTLSDATTTSHAPRESSSPPSTSDILTTMASTEGTSGDTGHTMAVTTQGSTPATTEISVTPSTQKMSPVSTFSTSTQEITTLSQSQHTGGMKTTRNPQTTGTTEVTTTLSASSSDQVQAETSSQTTLSPDTTTTSHAPRESSSPPSTSDMLTTTASTEGTSGDTGHTTAVTTQGSIPATTQLSTTFASQKMSTVSTPTTSSIQELSTLPQSQHTGSMEISSRPQTTSVTSTLSSSPSGSTPVQTRSVTSSSDERTNPTSSGVSNTSPATTEVLTPTSSPESTPGNTAPRTTETSTTTTTKVLMTSLQQKLPTGSTLGTSTPTEVTTTLSASSSDQVQVETTSQTTLSPDATTTSHAPRESSSPPSTSVILTTMASTEGTSGDTGHTTAVTDQGSTPATTEISVTPSTQKMSTVSTLVTSTQELTSSQSQRTGSMGTSSKPQATTPTEVTTSTLSSFSRGSLFSARNCCLQTKKPPLPAVVCLPDPSSVPSLMHSSKPQATTPTEVTTSTLSSFSRGSTQTQTVSWETSSSGKITAPSTSSRRTPSVATSDIFTTTDSTSGNAGHTLLTGSHSVITSRVASTTLGRLSTVAHRQSTQRSSTHSQSYLTESMGASSTSETSLLTEATTETSLCLFTWTHCDRDLLSWTSSSGLTTKTDNDRSTALSATSLTLPAPSTSTASRSTVPPAPLPPDQGISLFQIGFPLGSLCGIPSILQITVRSFSPSQTTMSSPTPTHLKEASQEGSVCHSGHSGVMLISLAPGEPYFRTTTSHFTMSSTSLIRKVESLINEFTSDWSFKPSDTEVTWVNVPAYPAQGRTLGANTYQAILSTDGSRSYALFLYQSGGMRWDVTQGLYNRVLMGFSSGDGYFENSPLIFRPAVEKYRPDRFLTPNYGSGDSRSTGYTGRCGPTTGSSVCSGWKVSLSSPAGAGTRFPALAPGSRDFGSGSSTQVCGAGSYAASLRAGRVLYVWHLGEFREGWRMHSPWQFDEDEGRHRTGLAAGTTSPLSASSTSSGGPELVVLGTRPPRPAWTFGDPHITTLDNAKYTFNGLGYFLLVQAQDRNSSFLLEGRTAQTDSANATNFIAFAAQYNTSSLKSPITVQWFLEPNDTIRVVHNNQTVAFNTSDTEDLPVFNATGVLLIQNGSQVSANFDGTVTISVIALSNILHASSSLSEEYRNHTKGLLGVWNDNPEDDFRMPNGSTIPSNTSEETLFHYGMTSETNGIGLLGVRTDPLPSEFTPIFLSQLWNKSGAGEDLISGCNEDAQCKFDILATGNRDIGQSTNSILRTFRHVNGTLNQYPPPIHYSSKIQAYKGREQWPLRSPATLRMSYSASPTSAVAFELFENGSLHVDTNIPRRTYLEILARDVKTNLSSVLQPETVACFCSKEEQCLYNETSKEGNSSTEVTSCKCDGNSFGRLCEHSKDLCTEPCFPNVDCIPGKGCQACPPNMTGDGRHCVAVEISEFCQNHSCPVNYCYNHGHCDISGPPDCQPTCTCAPAFTGNRCFLAGNNFTPIIYKELPLRTITLSLREDENASNADVNASVANVLENLDMRAFLSNSLVELIRTSPGAPVLGKPIHHWKVVSHFKYRPRGPLIHYLNNQLISAVMEAFLLQARQERRKRSGEARKNVRFFPISRADVQDGMALNLSMLDEYFTCDGYKGYHLVYSPQDGVTCVSPCSEGYCHNGGQCKHLPDGPQCTCATFSIYTSWGERCEHLSVKLGAFFGILFGALGALLLLAILACVVFHFCGCSMNKFSYPLDSEL
uniprot
proteins
function
FUNCTION: Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. {ECO:0000250|UniProtKB:Q99102}.
uniprot
proteins
mass_dalton
248041
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved into 2 subunits, mucin-4 alpha chain and mucin-4 beta chain. {ECO:0000305|PubMed:7440586}.; PTM: Mucin-4 alpha subunit is highly O-glycosylated. {ECO:0000269|PubMed:1379596}.; PTM: Mucin-4 beta subunit is predominantly N-glycosylated. {ECO:0000269|PubMed:1379596}.
uniprot
proteins
pubmed
10880365
uniprot
proteins
pubmed
12386815
uniprot
proteins
pubmed
1379596
uniprot
proteins
pubmed
15672420
uniprot
proteins
pubmed
16624867
uniprot
proteins
pubmed
7440586
uniprot
proteins
pubmed
8163496
uniprot
proteins
pubmed
9857062
uniprot
proteins
sequence_length
2344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Mucin-4 beta chain]: Cell membrane {ECO:0000305|PubMed:7440586}; Multi-pass membrane protein {ECO:0000305|PubMed:7440586}.; SUBCELLULAR LOCATION: [Mucin-4 alpha chain]: Secreted {ECO:0000305|PubMed:7440586}. Note=Secreted by proteolytic processing. {ECO:0000305|PubMed:7440586}.
uniprot
proteins
transmembrane_region
TRANSMEM 2173..2193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2301..2321; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins