Rnf2
entrez
19821
canonical
uniprot
Q9CQJ4
canonical
ensembl
ENSMUSG00000026484
resolver
ensp
ENSMUSP00000075476
resolver
ensp
ENSMUSP00000140896
resolver
ensp
ENSMUSP00000256482
resolver
ensp
ENSMUSP00000256488
resolver
enst
ENSMUST00000076110
resolver
enst
ENSMUST00000187048
resolver
genesymbol
Rnf2
resolver
genesymbol_syn
DinG
resolver
genesymbol_syn
Ring1b
resolver
uniprot
O35699
resolver
uniprot
O35729
resolver
uniprot
Q4FJV5
resolver
uniprot
Q8C1X8
resolver
uniprot_entry
RING2_MOUSE
resolver
uniprot_sec
O35699
resolver
uniprot_sec
O35729
resolver
uniprot_sec
Q4FJV5
resolver
uniprot_sec
Q8C1X8
resolver
amino_acid_sequence
MSQAVQTNGTQPLSKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQERVLARINKHNNQQALSHSIEEGLKIQAMNRLQRGKKQQIENGSGAEDNGDSSHCSNASTHSNQEAGPSNKRTKTSDDSGLELDNNNAAVAIDPVMDGASEIELVFRPHPTLMEKDDSAQTRYIKTSGNATVDHLSKYLAVRLALEELRSKGESNQMNLDTASEKQYTIYIATASGQFTVLNGSFSLELVSEKYWKVNKPMELYYAPTKEHK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15525528, PubMed:22325148, PubMed:28596365). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals (PubMed:15525528, PubMed:28596365). May be involved in the initiation of both imprinted and random X inactivation (PubMed:15525528). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16710298, PubMed:22325148). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:15525528, PubMed:16710298, PubMed:22325148). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:16710298). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (PubMed:15525528, PubMed:16710298). Plays a role in the transcriptional repression of genes that are required for pluripotency in embryonic stem cells, thereby contributing to differentiation of the ectodermal and endodermal germ layers (PubMed:22226355). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (PubMed:24034696). Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation (PubMed:24980959). {ECO:0000269|PubMed:12183370, ECO:0000269|PubMed:15525528, ECO:0000269|PubMed:16710298, ECO:0000269|PubMed:22226355, ECO:0000269|PubMed:22325148, ECO:0000269|PubMed:24034696, ECO:0000269|PubMed:24980959, ECO:0000269|PubMed:28596365}.
uniprot
proteins
mass_dalton
37623
uniprot
proteins
mutagenesis
MUTAGEN 69; /note="H->Y: Loss of ubiquitin ligase activity."; /evidence="ECO:0000269|PubMed:24980959
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:15525528, ECO:0000269|PubMed:22325148, ECO:0000269|PubMed:24980959}.
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated, by auto-ubiquitination (PubMed:16710298). Polyubiquitinated in the presence of UBE2D3 (in vitro) (By similarity). {ECO:0000250|UniProtKB:Q99496, ECO:0000269|PubMed:16710298}.
uniprot
proteins
pubmed
10369680
uniprot
proteins
pubmed
12183370
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15509584
uniprot
proteins
pubmed
15525528
uniprot
proteins
pubmed
16024804
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16710298
uniprot
proteins
pubmed
19170609
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22226355
uniprot
proteins
pubmed
22325148
uniprot
proteins
pubmed
22872859
uniprot
proteins
pubmed
24034696
uniprot
proteins
pubmed
24980959
uniprot
proteins
pubmed
28596365
uniprot
proteins
pubmed
28900001
uniprot
proteins
pubmed
9312051
uniprot
proteins
sequence_length
336
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12183370, ECO:0000269|PubMed:22325148, ECO:0000269|PubMed:24980959, ECO:0000269|PubMed:28900001}. Cytoplasm {ECO:0000269|PubMed:24980959}. Chromosome {ECO:0000269|PubMed:12183370, ECO:0000269|PubMed:22325148}. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells (PubMed:12183370). The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells (PubMed:12183370). Co-localizes with SAMD7 in nuclear polycomb bodies (PubMed:28900001). {ECO:0000269|PubMed:12183370, ECO:0000269|PubMed:28900001}.
uniprot
proteins