IFNL1
entrez
282618
canonical
uniprot
Q8IU54
canonical
ensembl
ENSG00000182393
resolver
ensembl
ENSG00000291872
resolver
ensp
ENSP00000329991
resolver
ensp
ENSP00000517467
resolver
enst
ENST00000333625
resolver
enst
ENST00000709027
resolver
genesymbol
IFNL1
resolver
genesymbol_syn
IL29
resolver
genesymbol_syn
ZCYTO21
resolver
hgnc
HGNC:18363
resolver
uniprot
A0AV25
resolver
uniprot
Q17R34
resolver
uniprot_entry
IFNL1_HUMAN
resolver
uniprot_sec
A0AV25
resolver
uniprot_sec
Q17R34
resolver
amino_acid_sequence
MAAAWTVVLVTLVLGLAVAGPVPTSKPTTTGKGCHIGRFKSLSPQELASFKKARDALEESLKLKNWSCSSPVFPGNWDLRLLQVRERPVALEAELALTLKVLEAAAGPALEDVLDQPLHTLHHILSQLQACIQPQPTAGPRPRGRLHHWLHRLQEAPKKESAGCLEASVTFNLFRLLTRDLKYVADGNLCLRTSTHPEST
uniprot
proteins
function
FUNCTION: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210, ECO:0000269|PubMed:20934432, ECO:0000303|PubMed:20712453, ECO:0000303|PubMed:24751921}.
uniprot
proteins
mass_dalton
21898
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Cleaved and inactivated by the 3C-like proteinase nsp5 from human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:39673710}.
uniprot
proteins
protein_family
Type-III (or lambda) interferon family
uniprot
proteins
pubmed
12469119
uniprot
proteins
pubmed
12483210
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20712453
uniprot
proteins
pubmed
20934432
uniprot
proteins
pubmed
24751921
uniprot
proteins
pubmed
39673710
uniprot
proteins
sequence_length
200
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12483210}.
uniprot
proteins