Icosl
entrez
50723
canonical
uniprot
Q9JHJ8
canonical
ensembl
ENSMUSG00000000732
resolver
ensp
ENSMUSP00000101032
resolver
genesymbol
Icosl
resolver
genesymbol
Icoslg
resolver
genesymbol_syn
B7h
resolver
genesymbol_syn
B7h2
resolver
genesymbol_syn
B7rp1
resolver
genesymbol_syn
Icosl
resolver
uniprot
Q544C7
resolver
uniprot_entry
ICOSL_MOUSE
resolver
uniprot_entry
Q544C7_MOUSE
resolver
amino_acid_sequence
MQLKCPCFVSLGTRQPVWKKLHVSSGFFSGLGLFLLLLSSLCAASAETEVGAMVGSNVVLSCIDPHRRHFNLSGLYVYWQIENPEVSVTYYLPYKSPGINVDSSYKNRGHLSLDSMKQGNFSLYLKNVTPQDTQEFTCRVFMNTATELVKILEEVVRLRVAANFSTPVISTSDSSNPGQERTYTCMSKNGYPEPNLYWINTTDNSLIDTALQNNTVYLNKLGLYDVISTLRLPWTSRGDVLCCVENVALHQNITSISQAESFTGNNTKNPQETHNNELKVLVPVLAVLAAAAFVSFIIYRRTRPHRSYTGPKTVQLELTDHA
uniprot
proteins
function
FUNCTION: Ligand for the T-cell-specific cell surface receptor ICOS (PubMed:10549624, PubMed:10617205, PubMed:10657606). Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; also induces B-cell proliferation and differentiation into plasma cells (PubMed:10549624, PubMed:10617205, PubMed:10657606). Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (Probable). During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype. {ECO:0000269|PubMed:10549624, ECO:0000269|PubMed:10617205, ECO:0000269|PubMed:10657606, ECO:0000305|PubMed:10617205}.
uniprot
proteins
mass_dalton
35960
uniprot
proteins
protein_family
BTN/MOG family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
10549624
uniprot
proteins
pubmed
10617205
uniprot
proteins
pubmed
10657606
uniprot
proteins
pubmed
11390480
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10549624, ECO:0000269|PubMed:10657606}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:11390480}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:11390480}.
uniprot
proteins
transmembrane_region
TRANSMEM 278..298; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins