Sacm1l
entrez
116482
canonical
uniprot
Q9ES21
canonical
ensembl
ENSRNOG00000005149
resolver
ensp
ENSRNOP00000105071
resolver
genesymbol
Sacm1l
resolver
genesymbol_syn
Sac1
resolver
uniprot_entry
SAC1_RAT
resolver
amino_acid_sequence
MAATAYEHLKLHITPEKFYVEACDDGADDVLIIDRVSTEVTLAVKKDVPPSAVTRPIYGIMGTIHLVAGNYLVVITKKMKVGEFFNHVIWKATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLSTDGFYFSTTYDLTHTLQRLSNTSPEFQEMSLLERADQRFVWNGHLLRELSAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYSGNRASFVQTRGSIPVFWSQRPNLKYKPDPQINKVANHMDGFQRHFDSQVIIYGKQVIINLVNHKGSEKPLEQTFAKMVSSLGSGMIRYIAFDFHKECKNMRWDRLSILLDQVAEMQDELSYFLVDSAGKVVTNQEGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQDEFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTQLGLVMDGFNSLLRYYKNNFSDGFRQDSIDLFLGNYSVDELDSHSPLSVPRDWKFLALPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWGVASIGTFFIILYNGKDFVDAPRLVQKEKID
uniprot
proteins
ec_number
3.1.3.64
uniprot
proteins
function
FUNCTION: Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:10887188, PubMed:27044890). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (By similarity). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (By similarity). {ECO:0000250|UniProtKB:Q9NTJ5, ECO:0000269|PubMed:10887188, ECO:0000269|PubMed:27044890}.
uniprot
proteins
mass_dalton
67039
uniprot
proteins
mutagenesis
MUTAGEN 391; /note="D->N: Reduces phosphatase activity towards PtdIns(4)P, but not towards PtdIns(3)P or PtdIns(3,5)P2."; /evidence="ECO:0000269|PubMed:10887188"; MUTAGEN 442; /note="A->V: Reduces phosphatase activity towards PtdIns(4)P, but not towards PtdIns(3)P or PtdIns(3,5)P2."; /evidence="ECO:0000269|PubMed:10887188
uniprot
proteins
pubmed
10887188
uniprot
proteins
pubmed
27044890
uniprot
proteins
sequence_length
587
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10887188}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9NTJ5}; Multi-pass membrane protein {ECO:0000255}. Note=Trafficking between the ER and Golgi is regulated by nutrient status and by TMEM39A (By similarity). Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) in the presence of phosphatidylinositol-4,5-bisphosphate (PubMed:27044890). {ECO:0000250|UniProtKB:Q9NTJ5, ECO:0000269|PubMed:27044890}.
uniprot
proteins
transmembrane_region
TRANSMEM 521..541; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 549..569; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins