PDYN
entrez
5173
canonical
uniprot
P01213
canonical
ensembl
ENSG00000101327
resolver
ensp
ENSP00000217305
resolver
ensp
ENSP00000440185
resolver
ensp
ENSP00000442259
resolver
enst
ENST00000217305
resolver
enst
ENST00000539905
resolver
enst
ENST00000540134
resolver
genesymbol
PDYN
resolver
hgnc
HGNC:8820
resolver
uniprot
A8K0Q3
resolver
uniprot_entry
PDYN_HUMAN
resolver
uniprot_sec
A8K0Q3
resolver
amino_acid_sequence
MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWERCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA
uniprot
proteins
disease_involvement
DISEASE: Spinocerebellar ataxia 23 (SCA23) [MIM:610245]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. {ECO:0000269|PubMed:21035104, ECO:0000269|PubMed:21712028, ECO:0000269|PubMed:23108490, ECO:0000269|PubMed:23471613}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). {ECO:0000250}.; FUNCTION: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin (By similarity). {ECO:0000250}.; FUNCTION: Leumorphin has a typical opioid activity and may have anti-apoptotic effect. {ECO:0000250}.
uniprot
proteins
mass_dalton
28385
uniprot
proteins
post_translational_modification
PTM: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
uniprot
proteins
protein_family
Opioid neuropeptide precursor family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16515546
uniprot
proteins
pubmed
17316701
uniprot
proteins
pubmed
21035104
uniprot
proteins
pubmed
21712028
uniprot
proteins
pubmed
23108490
uniprot
proteins
pubmed
23471613
uniprot
proteins
pubmed
6316163
uniprot
proteins
pubmed
9047294
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins