ARHGEF40
entrez
55701
canonical
uniprot
Q8TER5
canonical
ensembl
ENSG00000165801
resolver
ensp
ENSP00000298694
resolver
ensp
ENSP00000548047
resolver
ensp
ENSP00000548051
resolver
ensp
ENSP00000548052
resolver
ensp
ENSP00000620201
resolver
ensp
ENSP00000757115
resolver
genesymbol
ARHGEF40
resolver
genesymbol_syn
SOLO
resolver
hgnc
HGNC:25516
resolver
uniprot
A5PL07
resolver
uniprot
Q9BWP5
resolver
uniprot
Q9H7L6
resolver
uniprot
Q9NTF9
resolver
uniprot
Q9NW24
resolver
uniprot_entry
ARH40_HUMAN
resolver
uniprot_sec
A5PL07
resolver
uniprot_sec
Q9BWP5
resolver
uniprot_sec
Q9H7L6
resolver
uniprot_sec
Q9NTF9
resolver
uniprot_sec
Q9NW24
resolver
amino_acid_sequence
MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLAKVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLALKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAELICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLLCMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTGGVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEASPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL
uniprot
proteins
function
FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RHOA and RHOC (PubMed:15107133, PubMed:26823019). Promotes actin stress fiber formation, force-induced stress fiber reinforcement and organization of KRT8/KRT18 networks via activation of RHOA/ROCK signaling, which is mediated by N-terminus KRT18 binding (PubMed:26823019, PubMed:30929300). Regulates the formation or maintenance of properly elongated morphology of epithelial tubules, via mediation of the organization and orientation of KRT18 filaments (By similarity). Promotes RHOA-dependent, cell-cell contact mediated reorientation of endothelial cells and their actin stress fibers in response to mechanotransduction (PubMed:25795300). Positively regulates hemidesmosome formation via acting as a linker protein that anchors keratin filaments to hemidesmosomes (PubMed:29672603). Also required for JUP localization at cell-cell adhesion junctions (PubMed:26823019). {ECO:0000250|UniProtKB:A0A8I3PMN2, ECO:0000269|PubMed:15107133, ECO:0000269|PubMed:25795300, ECO:0000269|PubMed:26823019, ECO:0000269|PubMed:29672603, ECO:0000269|PubMed:30929300}.
uniprot
proteins
mass_dalton
164658
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="L->R: Disrupts N-terminus mediated interaction and colocalization with KRT18; when associated with R-17. Decreases formation of actin filaments and reinforcement of traction force generation; when associated with R-17."; /evidence="ECO:0000269|PubMed:30929300"; MUTAGEN 17; /note="L->R: Disrupts N-terminus mediated interaction and colocalization with KRT18; when associated with R-14. Decreases formation of actin filaments and reinforcement of traction force generation; when associated with R-14."; /evidence="ECO:0000269|PubMed:30929300"; MUTAGEN 49; /note="L->R: Disrupts N-terminus mediated interaction and colocalization with KRT18; when associated with R-52. Decreases formation of actin filaments and reinforcement of traction force generation; when associated with R-52."; /evidence="ECO:0000269|PubMed:30929300"; MUTAGEN 52; /note="L->R: Disrupts N-terminus mediated interaction and colocalization with KRT18; when associated with R-49. Decreases formation of actin filaments and reinforcement of traction force generation; when associated with R-49."; /evidence="ECO:0000269|PubMed:30929300"; MUTAGEN 1217; /note="L->E: Abolishes GEF activity and reduces force-induced actin stress fiber formation, organization, and focal adhesion formation."; /evidence="ECO:0000269|PubMed:25795300, ECO:0000269|PubMed:26823019
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15107133
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16143467
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25795300
uniprot
proteins
pubmed
26823019
uniprot
proteins
pubmed
29672603
uniprot
proteins
pubmed
30929300
uniprot
proteins
pubmed
32276436
uniprot
proteins
pubmed
34427245
uniprot
proteins
pubmed
39838643
uniprot
proteins
sequence_length
1519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15107133, ECO:0000269|PubMed:16143467, ECO:0000269|PubMed:25795300, ECO:0000269|PubMed:30929300}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:26823019}. Cell junction, hemidesmosome {ECO:0000269|PubMed:29672603}. Cell junction {ECO:0000269|PubMed:25795300}. Note=Concentrated in the perinuclear region (PubMed:16143467). Localizes to actin-based membrane ruffles (PubMed:15107133). Colocalizes with KRT8/KRT18 filament networks (PubMed:26823019, PubMed:30929300). Localization to hemidesmosomes increases during mechanical force tension (PubMed:29672603). {ECO:0000269|PubMed:15107133, ECO:0000269|PubMed:16143467, ECO:0000269|PubMed:26823019, ECO:0000269|PubMed:29672603, ECO:0000269|PubMed:30929300}.
uniprot
proteins