AADAT
entrez
51166
canonical
uniprot
Q8N5Z0
canonical
ensembl
ENSG00000109576
resolver
ensp
ENSP00000226840
resolver
ensp
ENSP00000336808
resolver
ensp
ENSP00000423190
resolver
ensp
ENSP00000423341
resolver
ensp
ENSP00000639354
resolver
genesymbol
AADAT
resolver
genesymbol_syn
KAT2
resolver
genesymbol_syn
KYAT2
resolver
hgnc
HGNC:17929
resolver
uniprot
B3KP84
resolver
uniprot
D3DP36
resolver
uniprot
Q4W5N8
resolver
uniprot
Q9UL02
resolver
uniprot_entry
AADAT_HUMAN
resolver
uniprot_entry
Q4W5N8_HUMAN
resolver
uniprot_sec
B3KP84
resolver
uniprot_sec
D3DP36
resolver
uniprot_sec
Q9UL02
resolver
activity_regulation
ACTIVITY REGULATION: Kynurenine transaminase activity is competitively inhibited by aminoadipate, asparagine, glutamate, histidine, cysteine, lysine, 3-hydroxy-kynurenine and phenylalanine. {ECO:0000269|PubMed:18620547}.
uniprot
proteins
amino_acid_sequence
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL
uniprot
proteins
ec_number
2.6.1.39
uniprot
proteins
ec_number
2.6.1.4
uniprot
proteins
ec_number
2.6.1.63
uniprot
proteins
ec_number
2.6.1.7
uniprot
proteins
ec_number
2.6.1.73
uniprot
proteins
function
FUNCTION: Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). {ECO:0000269|PubMed:12126930, ECO:0000269|PubMed:18056995, ECO:0000269|PubMed:18620547}.
uniprot
proteins
mass_dalton
47352
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 4/6.
uniprot
proteins
protein_family
Class-I pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
12126930
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18056995
uniprot
proteins
pubmed
18056996
uniprot
proteins
pubmed
18620547
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
uniprot
proteins