Gmeb1
entrez
500558
canonical
uniprot
Q9QUZ8
canonical
ensembl
ENSRNOG00000010910
resolver
ensembl
ENSRNOG00055025692
resolver
ensembl
ENSRNOG00060022687
resolver
ensembl
ENSRNOG00065027861
resolver
ensp
ENSRNOP00000014506
resolver
ensp
ENSRNOP00055036254
resolver
ensp
ENSRNOP00060032511
resolver
ensp
ENSRNOP00065039445
resolver
enst
ENSRNOT00000014506
resolver
enst
ENSRNOT00055044309
resolver
enst
ENSRNOT00060039314
resolver
enst
ENSRNOT00065048044
resolver
genesymbol
Gmeb1
resolver
uniprot
B0BN09
resolver
uniprot_entry
GMEB1_RAT
resolver
uniprot_sec
B0BN09
resolver
amino_acid_sequence
MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENSAAVVAVETHTIHKIEEGIDASSIEANEDMEIAYPITCGESKAVLLWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSARAPVPGQQTSVVQTPTSADGNITQIAISEESMEEAGLEWNSALTAAVTMATEEGIKKESEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIHAPFQVTDAAVLNNVANTFGLMDTVKRVLDNRRKQVEHGEEQFLYTLADLERQLEEQKKQAQDPRLKSQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQGTSPVTVHTLPSGPQLFRYATVVSSAKSNSPDTVTIHPSSSLALLSSTSMQDGSTLGNMATMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEADDPEGKAVILETELRTEEKVVANMEERQHQVHNVEIVVLED
uniprot
proteins
function
FUNCTION: Acts as a DNA-binding transcriptional regulator involved in modulating the expression of genes responsive to glucocorticoid signaling. Specifically binds AT-rich DNA motifs known as glucocorticoid modulatory elements (GMEs), repressing or enhancing transcription depending on cellular context. Forms heterodimeric complexes with GMEB2, which enhances its DNA-binding specificity and transcriptional activity. This complex plays a critical role in the repression of glucocorticoid receptor (GR/NR3C1) transcriptional activity, acting as a negative modulator of glucocorticoid signaling (By similarity). Regulates dopamine-enriched midbrain genes, including tyrosine hydroxylase/TH and the dopamine transporter SLC6A3, essential for dopamine signaling (By similarity). Also binds the transferrin receptor promoter. In the cytoplasm, inhibits caspase activation and neuronal apoptosis by stabilizing CFLARL and blocking pro-caspase 8 activation (By similarity). {ECO:0000250|UniProtKB:Q9JL60, ECO:0000250|UniProtKB:Q9Y692}.
uniprot
proteins
mass_dalton
61194
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7665613
uniprot
proteins
sequence_length
562
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y692}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y692}. Note=May be also cytoplasmic. {ECO:0000250|UniProtKB:Q9Y692}.
uniprot
proteins