Srpk2
entrez
20817
canonical
uniprot
O54781
canonical
ensembl
ENSMUSG00000062604
resolver
ensp
ENSMUSP00000085734
resolver
ensp
ENSMUSP00000276198
resolver
ensp
ENSMUSP00000276199
resolver
ensp
ENSMUSP00000276200
resolver
ensp
ENSMUSP00000276201
resolver
ensp
ENSMUSP00000276207
resolver
ensp
ENSMUSP00000276211
resolver
ensp
ENSMUSP00000276212
resolver
ensp
ENSMUSP00000276213
resolver
ensp
ENSMUSP00000276214
resolver
ensp
ENSMUSP00000276216
resolver
ensp
ENSMUSP00000332155
resolver
enst
ENSMUST00000088392
resolver
genesymbol
Srpk2
resolver
uniprot
A0A0R4J124
resolver
uniprot
Q8C9R8
resolver
uniprot
Q8CBI1
resolver
uniprot
Q8VCD9
resolver
uniprot_entry
A0A0R4J124_MOUSE
resolver
uniprot_entry
Q8C9R8_MOUSE
resolver
uniprot_entry
Q8CBI1_MOUSE
resolver
uniprot_entry
SRPK2_MOUSE
resolver
uniprot_sec
Q8VCD9
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Ser-50 and Ser-581. {ECO:0000250|UniProtKB:Q96SB4}.
uniprot
proteins
amino_acid_sequence
MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPLPDPAPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKILEENITSAEASGEQDGEYQPEVTLKAADLEDTTEEETAKDNGEVEDQEEKEDAEKENAEKDEDDVEQELANLDPTWVESPKANGHIENGPFSLEQQLEDEEDDEDDCANPEEYNLDEPNAESDYTYSSSYEQFNGELPNGQHKTSEFPTPLFSGPLEPVACGSVISEGSPLTEQEESSPSHDRSRTVSASSTGDLPKTKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:9446799). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (By similarity). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (By similarity). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (By similarity). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (By similarity). Phosphorylates the N-terminus of ERC1 (PubMed:30745339). {ECO:0000250|UniProtKB:P78362, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:30745339, ECO:0000269|PubMed:9446799}.
uniprot
proteins
mass_dalton
76757
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-485 by PKB/AKT1 enhances its stimulatory activity in triggering cyclin-D1 (CCND1) expression and promoting apoptosis in neurons, which can be blocked by YWHAB. It also enhances its protein kinase activity toward ACIN1 and SRSF2, promotes its nuclear translocation and prevents its proteolytic cleavage (By similarity). {ECO:0000250}.; PTM: Proteolytically cleaved at Asp-137 and Asp-401 by caspase-3 during apoptotic cell death. Cleavage at Asp-137 which is the major site of cleavage, produces a small N-terminal fragment that translocates into nucleus and promotes VP16-induced apoptosis (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18559500
uniprot
proteins
pubmed
19592491
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30745339
uniprot
proteins
pubmed
9446799
uniprot
proteins
sequence_length
681
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9446799}. Nucleus, nucleoplasm {ECO:0000269|PubMed:9446799}. Nucleus speckle {ECO:0000250|UniProtKB:P78362}. Chromosome {ECO:0000250|UniProtKB:P78362}. Note=Shuttles between the nucleus and the cytoplasm (By similarity). KAT5/TIP60 inhibits its nuclear translocation (By similarity). Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation (By similarity). Preferentially localizes across the entire gene coding region (By similarity). During transcription, accumulates at chromatin loci where unscheduled R-loops form and colocalizes with paused 'Ser-5'-phosphorylated POLR2A/RNA polymerase II and helicase DDX23 (By similarity). {ECO:0000250|UniProtKB:P78362}.
uniprot
proteins