Map4k4
entrez
26921
canonical
uniprot
P97820
canonical
ensembl
ENSMUSG00000026074
resolver
ensp
ENSMUSP00000126961
resolver
ensp
ENSMUSP00000141400
resolver
ensp
ENSMUSP00000141613
resolver
ensp
ENSMUSP00000141665
resolver
ensp
ENSMUSP00000141862
resolver
ensp
ENSMUSP00000142056
resolver
enst
ENSMUST00000192509
resolver
enst
ENSMUST00000193682
resolver
enst
ENSMUST00000195259
resolver
enst
ENSMUST00000195636
resolver
enst
ENSMUST00000195860
resolver
genesymbol
Map4k4
resolver
genesymbol_syn
Nik
resolver
uniprot
A0A0A6YW53
resolver
uniprot
A0A0A6YWM8
resolver
uniprot
A0A0A6YWR8
resolver
uniprot
A0A0A6YX68
resolver
uniprot
A0A0A6YXM6
resolver
uniprot
B2RUE8
resolver
uniprot
B7ZNR8
resolver
uniprot
B7ZNR9
resolver
uniprot
Q3UTY9
resolver
uniprot_entry
A0A0A6YW53_MOUSE
resolver
uniprot_entry
A0A0A6YWM8_MOUSE
resolver
uniprot_entry
A0A0A6YWR8_MOUSE
resolver
uniprot_entry
A0A0A6YX68_MOUSE
resolver
uniprot_entry
A0A0A6YXM6_MOUSE
resolver
uniprot_entry
B2RUE8_MOUSE
resolver
uniprot_entry
B7ZNR8_MOUSE
resolver
uniprot_entry
B7ZNR9_MOUSE
resolver
uniprot_entry
M4K4_MOUSE
resolver
uniprot_entry
Q3UTY9_MOUSE
resolver
amino_acid_sequence
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTVTAAIKVMDVTEDEEEEITLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGGPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEILQQQLLQEQAMLLHDHRRPHAQQQPPPPQQQDRSKPSFHAPEPKPHYDPADRAREVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQDPCPPSRSEGLSQSSDSKSEVPEPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQGGGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSPRQESAAKKPDDKKEVFRSLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEEEDVEQEGADDSTSGPEDTRAASSPNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGLRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLISRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELLHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCGRNDKVFFSSVRSGGSSQVYFMTLGRTSLLSW
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF. Appears to act upstream of the JUN N-terminal pathway (PubMed:10669731, PubMed:9135144). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. Phosphorylates SMAD1 on Thr-322 (By similarity). {ECO:0000250|UniProtKB:O95819, ECO:0000269|PubMed:10669731, ECO:0000269|PubMed:9135144}.
uniprot
proteins
mass_dalton
140602
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
10669731
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9135144
uniprot
proteins
sequence_length
1233
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins