MNAT1
entrez
4331
canonical
uniprot
P51948
canonical
ensembl
ENSG00000020426
resolver
ensp
ENSP00000261245
resolver
ensp
ENSP00000446437
resolver
ensp
ENSP00000451017
resolver
ensp
ENSP00000675315
resolver
genesymbol
MNAT1
resolver
genesymbol_syn
CAP35
resolver
genesymbol_syn
MAT1
resolver
genesymbol_syn
RNF66
resolver
hgnc
HGNC:7181
resolver
uniprot
A0A024R688
resolver
uniprot
G3V1U8
resolver
uniprot
Q15817
resolver
uniprot
Q6ICQ7
resolver
uniprot_entry
A0A024R688_HUMAN
resolver
uniprot_entry
MAT1_HUMAN
resolver
uniprot_sec
G3V1U8
resolver
uniprot_sec
Q15817
resolver
uniprot_sec
Q6ICQ7
resolver
amino_acid_sequence
MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRVQLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKKKMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHKLEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPS
uniprot
proteins
function
FUNCTION: Component of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalyzing the activating threonine phosphorylation of CDKs (PubMed:41100585). Binds and activates CDK7, the catalytic subunit of CAK (PubMed:41100585). CAK activates major mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, and plays a key role in regulating cell cycle progression (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts (PubMed:10024882). Involved in cell cycle control and in RNA transcription by RNA polymerase II (PubMed:10024882). {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:41100585}.
uniprot
proteins
mass_dalton
35823
uniprot
proteins
pubmed
10024882
uniprot
proteins
pubmed
11056162
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
41100585
uniprot
proteins
pubmed
8521393
uniprot
proteins
pubmed
8521818
uniprot
proteins
pubmed
9852112
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins