Aqp4
entrez
11829
canonical
uniprot
P55088
canonical
ensembl
ENSMUSG00000024411
resolver
ensp
ENSMUSP00000078088
resolver
ensp
ENSMUSP00000157000
resolver
ensp
ENSMUSP00000157060
resolver
ensp
ENSMUSP00000157152
resolver
ensp
ENSMUSP00000157239
resolver
ensp
ENSMUSP00000157337
resolver
ensp
ENSMUSP00000157347
resolver
ensp
ENSMUSP00000159185
resolver
enst
ENSMUST00000079081
resolver
genesymbol
Aqp4
resolver
uniprot
A0A0R4J0Z3
resolver
uniprot
P97818
resolver
uniprot
Q4FJP1
resolver
uniprot
Q50H70
resolver
uniprot
Q61131
resolver
uniprot
Q61132
resolver
uniprot
Q8BR89
resolver
uniprot
Q8VHE4
resolver
uniprot
Q8VHE5
resolver
uniprot
Q9EQI3
resolver
uniprot_entry
A0A0R4J0Z3_MOUSE
resolver
uniprot_entry
AQP4_MOUSE
resolver
uniprot_entry
Q50H70_MOUSE
resolver
uniprot_entry
Q8BR89_MOUSE
resolver
uniprot_sec
P97818
resolver
uniprot_sec
Q4FJP1
resolver
uniprot_sec
Q61131
resolver
uniprot_sec
Q61132
resolver
uniprot_sec
Q8VHE4
resolver
uniprot_sec
Q8VHE5
resolver
uniprot_sec
Q9EQI3
resolver
amino_acid_sequence
MSDGAAARRWGKCGHSCSRESIMVAFKGVWTQAFWKAVSAEFLATLIFVLLGVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIIAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWANHWIYWVGPIMGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGSYMEVEDNRSQVETEDLILKPGVVHVIDIDRGEEKKGKDSSGEVLSSV
uniprot
proteins
function
FUNCTION: Forms a water-specific channel (PubMed:18286643, PubMed:8660998, PubMed:9276712). Plays an important role in brain water homeostasis and in glymphatic solute transport (PubMed:22896675, PubMed:27751903, PubMed:30557661, PubMed:30561329). Required for a normal rate of water exchange across the blood brain interface (PubMed:30557661). Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP (PubMed:22896675, PubMed:27751903, PubMed:30561329). Plays a redundant role in urinary water homeostasis and urinary concentrating ability (PubMed:9276712). {ECO:0000269|PubMed:18286643, ECO:0000269|PubMed:22896675, ECO:0000269|PubMed:27751903, ECO:0000269|PubMed:30557661, ECO:0000269|PubMed:30561329, ECO:0000269|PubMed:8660998, ECO:0000269|PubMed:9276712}.
uniprot
proteins
mass_dalton
34436
uniprot
proteins
mutagenesis
MUTAGEN 111; /note="S->A: Loss of phosphorylation by PKG (in vitro). No effect on location at cell membrane."; /evidence="ECO:0000269|PubMed:18286643
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PKC at Ser-180 reduces conductance by 50% (By similarity). Phosphorylation by PKG at Ser-111 in response to glutamate increases conductance by 40%; this increase is not due to increased presence at the cell membrane (PubMed:18286643). {ECO:0000250|UniProtKB:P47863, ECO:0000269|PubMed:18286643}.; PTM: Isoform 2: Palmitoylated on its N-terminal region. Isoform 1: Not palmitoylated. {ECO:0000250|UniProtKB:P47863}.
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
10915655
uniprot
proteins
pubmed
10960499
uniprot
proteins
pubmed
11406631
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641094
uniprot
proteins
pubmed
18286643
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22896675
uniprot
proteins
pubmed
27751903
uniprot
proteins
pubmed
29055082
uniprot
proteins
pubmed
30557661
uniprot
proteins
pubmed
30561329
uniprot
proteins
pubmed
8660998
uniprot
proteins
pubmed
9143504
uniprot
proteins
pubmed
9276712
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18286643, ECO:0000269|PubMed:8660998}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55087}. Basolateral cell membrane {ECO:0000269|PubMed:10915655, ECO:0000269|PubMed:16641094, ECO:0000269|PubMed:27751903, ECO:0000269|PubMed:9276712}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55087}. Endosome membrane {ECO:0000250|UniProtKB:P47863}. Cell membrane, sarcolemma {ECO:0000269|PubMed:29055082}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55087}. Cell projection {ECO:0000269|PubMed:22896675}. Note=Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane (By similarity). Detected on brain astrocyte processes and astrocyte endfeet close to capillaries (PubMed:22896675). {ECO:0000250|UniProtKB:P47863, ECO:0000269|PubMed:22896675}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..57; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55087"; TRANSMEM 70..89; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55087"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55087"; TRANSMEM 156..176; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55087"; TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55087"; TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55087
uniprot
proteins