Azi2
entrez
27215
canonical
uniprot
Q9QYP6
canonical
ensembl
ENSMUSG00000039285
resolver
ensp
ENSMUSP00000044350
resolver
ensp
ENSMUSP00000114980
resolver
ensp
ENSMUSP00000118765
resolver
ensp
ENSMUSP00000316897
resolver
ensp
ENSMUSP00000316901
resolver
ensp
ENSMUSP00000316913
resolver
genesymbol
Azi2
resolver
genesymbol_syn
Az2
resolver
genesymbol_syn
Nap1
resolver
genesymbol_syn
Tbkp2
resolver
uniprot
Q3TIN1
resolver
uniprot
Q3V3R2
resolver
uniprot
Q9CUI5
resolver
uniprot_entry
AZI2_MOUSE
resolver
uniprot_sec
Q3TIN1
resolver
uniprot_sec
Q3V3R2
resolver
uniprot_sec
Q9CUI5
resolver
amino_acid_sequence
MDTLVEDDICILNHEKAHRREAVTPLSAYPGDESVASHFALVTAYEDIKKRLKDSEKENSFLKKRIRALEERLVGARADEETSSVGREQVNKAYHAYREVCIDRDNLKNQLEKINKDNSESLKMLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSSWEVEKLSCDLKIHGLEQELGLLRKECSDLRTELQKARQTGPPQEDILQGRDVIRPSLSREEHVPHQGLHHSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSAAVKKACTPVGCVEDLGRDSTKLHLTNFTATYKRHPSLSPNGKAPCYAPSSPLPGDRKVFSDKAVLQSWTDNERLVPNDGADFPEHSSYGRNSLEDNSWVFPSPPKSSETAFGENKSKILPLSNLPPLHYLDQQNQNCLYKS
uniprot
proteins
function
FUNCTION: Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:22539786}.
uniprot
proteins
mass_dalton
46091
uniprot
proteins
mutagenesis
MUTAGEN 236; /note="Y->A: Abolishes interaction with TBK1 but not with IKBKE."; /evidence="ECO:0000269|PubMed:17568778"; MUTAGEN 237; /note="W->A: No effect on interaction with TBK1 and IKBKE."; /evidence="ECO:0000269|PubMed:17568778"; MUTAGEN 238; /note="E->A: No effect on interaction with TBK1 and IKBKE."; /evidence="ECO:0000269|PubMed:17568778"; MUTAGEN 253; /note="Q->A: Abolishes interaction with TBK1 and IKBKE."; /evidence="ECO:0000269|PubMed:17568778"; MUTAGEN 257; /note="L->A: Abolishes interaction with TBK1 and IKBKE."; /evidence="ECO:0000269|PubMed:17568778
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated via 'Lys-48'-linked polyubiquitination by TRIM38, leading to its degradation. {ECO:0000269|PubMed:22539786}.
uniprot
proteins
pubmed
10580148
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17568778
uniprot
proteins
pubmed
22539786
uniprot
proteins
sequence_length
405
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10580148}.
uniprot
proteins