Pnrc2
entrez
100125373
canonical
uniprot
Q66HE1
canonical
ensembl
ENSRNOG00000070268
resolver
ensembl
ENSRNOG00055026474
resolver
ensembl
ENSRNOG00060031526
resolver
ensembl
ENSRNOG00065025989
resolver
ensp
ENSRNOP00000084836
resolver
ensp
ENSRNOP00055037401
resolver
ensp
ENSRNOP00055037429
resolver
ensp
ENSRNOP00060045162
resolver
ensp
ENSRNOP00060045171
resolver
ensp
ENSRNOP00065036666
resolver
ensp
ENSRNOP00065036683
resolver
enst
ENSRNOT00000104557
resolver
enst
ENSRNOT00055045648
resolver
enst
ENSRNOT00055045677
resolver
enst
ENSRNOT00060054621
resolver
enst
ENSRNOT00060054633
resolver
enst
ENSRNOT00065044771
resolver
enst
ENSRNOT00065044788
resolver
genesymbol
Pnrc2
resolver
uniprot_entry
PNRC2_RAT
resolver
amino_acid_sequence
MGGGERYNIPDPQSRNASKNQQQHNRQKTKDQNSQMKIVHKKKERGHGYNPSAVQNGGKTKSLSNNSNWNASLSSPSLLFKSQASQNYAGAKFSEPPSPSVLPKPPSHWVHVSLNPSDKETMTFQLKTLLKVQV
uniprot
proteins
function
FUNCTION: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure. {ECO:0000250|UniProtKB:Q9CR73, ECO:0000250|UniProtKB:Q9NPJ4}.
uniprot
proteins
mass_dalton
14881
uniprot
proteins
protein_family
PNRC family
uniprot
proteins
protein_family
PNRC2 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}.
uniprot
proteins