IMPDH2
entrez
3615
canonical
uniprot
P12268
canonical
ensembl
ENSG00000178035
resolver
ensp
ENSP00000321584
resolver
ensp
ENSP00000393525
resolver
ensp
ENSP00000403502
resolver
ensp
ENSP00000503874
resolver
enst
ENST00000326739
resolver
enst
ENST00000429182
resolver
enst
ENST00000442157
resolver
enst
ENST00000678724
resolver
genesymbol
IMPDH2
resolver
genesymbol_syn
IMPD2
resolver
genesymbol_syn
IMPDH
resolver
hgnc
HGNC:6053
resolver
uniprot
A0A7I2YQK5
resolver
uniprot
E7ETK5
resolver
uniprot
H0Y4R1
resolver
uniprot
Q6LEF3
resolver
uniprot_entry
A0A7I2YQK5_HUMAN
resolver
uniprot_entry
E7ETK5_HUMAN
resolver
uniprot_entry
H0Y4R1_HUMAN
resolver
uniprot_entry
IMDH2_HUMAN
resolver
uniprot_sec
Q6LEF3
resolver
activity_regulation
ACTIVITY REGULATION: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. Subject to product inhibition by XMP and NADH (PubMed:7903306). Also inhibited by ADP. {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:7903306}.
uniprot
proteins
amino_acid_sequence
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
uniprot
proteins
ec_number
1.1.1.205
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000269|PubMed:14766016, ECO:0000269|PubMed:7763314, ECO:0000269|PubMed:7903306}.
uniprot
proteins
mass_dalton
55805
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1. {ECO:0000269|PubMed:7763314, ECO:0000269|PubMed:7903306}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated leading to its degradation by the proteasome. {ECO:0000269|PubMed:30293565}.; PTM: The N-terminus is blocked.; PTM: Acetylated by CLOCK in a circadian manner (PubMed:28985504). {ECO:0000269|PubMed:28985504}.
uniprot
proteins
protein_family
IMPDH/GMPR family
uniprot
proteins
pubmed
10097070
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14766016
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17496727
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
1969416
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24477477
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28985504
uniprot
proteins
pubmed
2902093
uniprot
proteins
pubmed
30293565
uniprot
proteins
pubmed
31337707
uniprot
proteins
pubmed
7763314
uniprot
proteins
pubmed
7896827
uniprot
proteins
pubmed
7903306
uniprot
proteins
pubmed
7999076
uniprot
proteins
pubmed
8098009
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000269|PubMed:14766016}. Cytoplasm, cytosol {ECO:0000269|PubMed:31337707}. Note=Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine-nucleotide depletion. {ECO:0000269|PubMed:24477477, ECO:0000269|PubMed:31337707}.
uniprot
proteins