CTF1
entrez
1489
canonical
uniprot
Q16619
canonical
ensembl
ENSG00000150281
resolver
ensp
ENSP00000279804
resolver
ensp
ENSP00000378465
resolver
genesymbol
CTF1
resolver
hgnc
HGNC:2499
resolver
uniprot
A8MVX4
resolver
uniprot
Q5U5Y7
resolver
uniprot_entry
CTF1_HUMAN
resolver
uniprot_sec
A8MVX4
resolver
uniprot_sec
Q5U5Y7
resolver
amino_acid_sequence
MSRREGSLEDPQTDSSVSLLPHLEAKIRQTHSLAHLLTKYAEQLLQEYVQLQGDPFGLPSFSPPRLPVAGLSAPAPSHAGLPVHERLRLDAAALAALPPLLDAVCRRQAELNPRAPRLLRRLEDAARQARALGAAVEALLAALGAANRGPRAEPPAATASAASATGVFPAKVLGLRVCGLYREWLSRTEGDLGQLLPGGSA
uniprot
proteins
function
FUNCTION: Functions as a cytokine that binds to the LIF receptor complex (PubMed:8833032). The LIF receptor complex indeed consists of two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell (By similarity). Functionally, acts as a potent cardiac survival factor, and promotes cardiomyocyte proliferation and hypertrophy (PubMed:8833032). Mechanistically, ligand binding to LIFR, induces heterodimerization with IL6ST/gp130 activating JAK tyrosine kinases (JAK1 or JAK2 and to a lesser extent TYK2) bound to their intracellular domains (By similarity). These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (By similarity). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activator of transcription STAT3 (By similarity). {ECO:0000250|UniProtKB:Q60753, ECO:0000269|PubMed:8833032}.
uniprot
proteins
mass_dalton
21227
uniprot
proteins
protein_family
IL-6 superfamily
uniprot
proteins
pubmed
11058912
uniprot
proteins
pubmed
15339391
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
8833032
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins