ARID4A
entrez
5926
canonical
uniprot
P29374
canonical
ensembl
ENSG00000032219
resolver
ensp
ENSP00000344556
resolver
ensp
ENSP00000347602
resolver
ensp
ENSP00000378597
resolver
ensp
ENSP00000611449
resolver
ensp
ENSP00000772876
resolver
genesymbol
ARID4A
resolver
genesymbol_syn
RBBP1
resolver
genesymbol_syn
RBP1
resolver
hgnc
HGNC:9885
resolver
uniprot
Q05CG0
resolver
uniprot
Q15991
resolver
uniprot
Q15992
resolver
uniprot
Q15993
resolver
uniprot_entry
ARI4A_HUMAN
resolver
uniprot_entry
Q05CG0_HUMAN
resolver
uniprot_sec
Q15991
resolver
uniprot_sec
Q15992
resolver
uniprot_sec
Q15993
resolver
amino_acid_sequence
MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPLRVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETLDQLPLTNPEHFGTPVIAKKTNRGRRSSLPVTEDEKEEESSEEEDEDKRRLNDELLGKVVSVVSATERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILNLPESELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEEEVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEGLCERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNSGLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARSPARISPHIKDGEKDKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR
uniprot
proteins
function
FUNCTION: DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}.
uniprot
proteins
mass_dalton
142752
uniprot
proteins
mutagenesis
MUTAGEN 583; /note="Y->A: No effect on binding to trimethylated lysines."; /evidence="ECO:0000269|PubMed:22247551"; MUTAGEN 592; /note="Y->A: Significantly reduces affinity for trimethylated lysines."; /evidence="ECO:0000269|PubMed:22247551"; MUTAGEN 612; /note="Y->A: Abolishes binding to trimethylated lysines."; /evidence="ECO:0000269|PubMed:22247551"; MUTAGEN 615; /note="W->A: Abolishes binding to trimethylated lysines."; /evidence="ECO:0000269|PubMed:22247551"; MUTAGEN 619; /note="Y->A: Abolishes binding to trimethylated lysines."; /evidence="ECO:0000269|PubMed:22247551
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14581478
uniprot
proteins
pubmed
17043311
uniprot
proteins
pubmed
1857421
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22247551
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23487765
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24379399
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29408527
uniprot
proteins
pubmed
8414517
uniprot
proteins
pubmed
8455946
uniprot
proteins
sequence_length
1257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:8414517, ECO:0000269|PubMed:8455946}.
uniprot
proteins