CCR8
entrez
1237
canonical
uniprot
P51685
canonical
ensembl
ENSG00000179934
resolver
ensp
ENSP00000326432
resolver
genesymbol
CCR8
resolver
genesymbol_syn
CKRL1
resolver
genesymbol_syn
CMKBR8
resolver
genesymbol_syn
CMKBRL2
resolver
hgnc
HGNC:1609
resolver
uniprot
B2RC64
resolver
uniprot
Q3KNQ8
resolver
uniprot
Q3KNR3
resolver
uniprot
Q9BYX5
resolver
uniprot_entry
CCR8_HUMAN
resolver
uniprot_sec
B2RC64
resolver
uniprot_sec
Q3KNQ8
resolver
uniprot_sec
Q3KNR3
resolver
uniprot_sec
Q9BYX5
resolver
amino_acid_sequence
MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18 (PubMed:23999500, PubMed:35041514). Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells (PubMed:23999500). In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways (PubMed:35041514). Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage (By similarity). {ECO:0000250|UniProtKB:P56484, ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:23999500, ECO:0000269|PubMed:35041514, ECO:0000269|PubMed:9207005, ECO:0000269|PubMed:9469461, ECO:0000269|PubMed:9521068}.; FUNCTION: (Microbial infection) Acts as a coreceptor for HIV-1 and HIV-2 viruses. {ECO:0000269|PubMed:20947116}.; FUNCTION: (Microbial infection) Acts as a receptor for Kaposi virus protein vCCL1/K6 and thereby inhibits apoptosis in the targeted cells. {ECO:0000269|PubMed:20947116}.
uniprot
proteins
mass_dalton
40844
uniprot
proteins
mutagenesis
MUTAGEN 113; /note="Y->A: Strong decrease in ability to mediate calcium mobilization."; /evidence="ECO:0000269|PubMed:38040762"; MUTAGEN 172; /note="Y->A: Strong decrease in ability to mediate calcium mobilization."; /evidence="ECO:0000269|PubMed:38040762"; MUTAGEN 286; /note="E->A: Strong decrease in ability to mediate calcium mobilization."; /evidence="ECO:0000269|PubMed:38040762
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10377196
uniprot
proteins
pubmed
10540332
uniprot
proteins
pubmed
12551893
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
20947116
uniprot
proteins
pubmed
23999500
uniprot
proteins
pubmed
35041514
uniprot
proteins
pubmed
38040762
uniprot
proteins
pubmed
8816377
uniprot
proteins
pubmed
8886020
uniprot
proteins
pubmed
8977299
uniprot
proteins
pubmed
9207005
uniprot
proteins
pubmed
9469461
uniprot
proteins
pubmed
9521068
uniprot
proteins
pubmed
9834206
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:35041514}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 36..63; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 74..93; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 108..129; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 147..171; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 203..222; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 239..263; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 281..304; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins