Mapkap1
entrez
296648
canonical
uniprot
Q6AYF1
canonical
ensembl
ENSRNOG00000017583
resolver
ensembl
ENSRNOG00055006373
resolver
ensembl
ENSRNOG00060027796
resolver
ensembl
ENSRNOG00065026595
resolver
ensp
ENSRNOP00000078499
resolver
ensp
ENSRNOP00000091071
resolver
ensp
ENSRNOP00000102274
resolver
ensp
ENSRNOP00000102771
resolver
ensp
ENSRNOP00055008037
resolver
ensp
ENSRNOP00060040156
resolver
ensp
ENSRNOP00065037691
resolver
enst
ENSRNOT00000116389
resolver
enst
ENSRNOT00000125836
resolver
enst
ENSRNOT00000139203
resolver
enst
ENSRNOT00055010359
resolver
enst
ENSRNOT00060048240
resolver
enst
ENSRNOT00065045928
resolver
genesymbol
Mapkap1
resolver
genesymbol_syn
Sin1
resolver
uniprot
A0A8I6AEY0
resolver
uniprot
A0ABK0L266
resolver
uniprot_entry
A0A8I6AEY0_RAT
resolver
uniprot_entry
A0ABK0L266_RAT
resolver
uniprot_entry
SIN1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) promotes MTOR activation by relieving MAPKAP1/SIN1-mediated inhibition of MTOR that takes place in absence of PI(3,4,5)P3. {ECO:0000250|UniProtKB:Q9BPZ7}.
uniprot
proteins
amino_acid_sequence
MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKTHPPSVPGDSGSEVQGSSGETQGYIYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSLKEKPPSSGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKALKRRKGSQKISGPQYRLEKQSEPNIGVDLESTLESQNAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDCDLLCACDLAEEKSPSHAVFKLTYLSSHDYKHLYFESDAATVSEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
uniprot
proteins
function
FUNCTION: Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (By similarity). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (By similarity). In contrast to mTORC1, mTORC2 is nutrient-insensitive (By similarity). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (By similarity). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (By similarity). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (By similarity). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (By similarity). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (By similarity). Inhibits HRAS and KRAS independently of mTORC2 complex (By similarity). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (By similarity). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (By similarity). {ECO:0000250|UniProtKB:Q8BKH7, ECO:0000250|UniProtKB:Q9BPZ7}.
uniprot
proteins
mass_dalton
59043
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-128 by PKC promotes relocalization to the perinuclear region, where the mTORC2 complex specifically mediates phosphorylation of SGK1. Phosphorylated at Thr-86 by AKT1 or RPS6KB1 in the presence of growth factors; the effect of this phosphorylation is however unclear. According to two studies, phosphorylation at Thr-86 by AKT1 is part of a positive feedback loop that increases mTORC2 activation. According to another study, phosphorylation at Thr-86 and Thr-398 by RPS6KB1 promotes dissociation from the mTORC2 complex, leading to inhibit mTORC2 signaling. {ECO:0000250|UniProtKB:Q8BKH7}.
uniprot
proteins
protein_family
SIN1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
522
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BPZ7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BPZ7}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BPZ7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BPZ7}. Early endosome membrane {ECO:0000250|UniProtKB:Q9BPZ7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BPZ7}. Late endosome membrane {ECO:0000250|UniProtKB:Q9BPZ7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BPZ7}. Lysosome membrane {ECO:0000250|UniProtKB:Q9BPZ7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BPZ7}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9BPZ7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BPZ7}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9BPZ7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BPZ7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8BKH7}. Nucleus {ECO:0000250|UniProtKB:Q9BPZ7}. Note=The mTORC2 complex localizes to membranes: mTORC2 is active at the plasma membrane, endoplasmic reticulum membrane, lysosomes and perinuclear region. In lysosomal membrane, mTORC2 is sensitive to lysosomal positioning in the cell (By similarity). Following phosphorylation by PKC, localizes to the perinuclear region, where the mTORC2 complex specifically phosphorylates SGK1, but not AKT (By similarity). {ECO:0000250|UniProtKB:Q8BKH7, ECO:0000250|UniProtKB:Q9BPZ7}.
uniprot
proteins