Cyth2
entrez
19158
canonical
uniprot
P63034
canonical
ensembl
ENSMUSG00000003269
resolver
ensp
ENSMUSP00000103357
resolver
ensp
ENSMUSP00000147457
resolver
enst
ENSMUST00000107729
resolver
genesymbol
Cyth2
resolver
genesymbol_syn
Pscd2
resolver
genesymbol_syn
Sec7b
resolver
uniprot
E9QJX3
resolver
uniprot
F6U9M1
resolver
uniprot
O89099
resolver
uniprot
P97695
resolver
uniprot
Q3UP39
resolver
uniprot
Q99KH2
resolver
uniprot_entry
CYH2_MOUSE
resolver
uniprot_entry
F6U9M1_MOUSE
resolver
uniprot_entry
Q99KH2_MOUSE
resolver
uniprot_sec
E9QJX3
resolver
uniprot_sec
O89099
resolver
uniprot_sec
P97695
resolver
uniprot_sec
Q3UP39
resolver
amino_acid_sequence
MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVEHELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLSVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEDLLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
uniprot
proteins
function
FUNCTION: Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (PubMed:18042453). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (PubMed:25326380). {ECO:0000250|UniProtKB:Q99418, ECO:0000269|PubMed:18042453, ECO:0000269|PubMed:25326380}.
uniprot
proteins
mass_dalton
46571
uniprot
proteins
mutagenesis
MUTAGEN 268; /note="K->A: Abolishes phosphatidylinositol 3,4,5-trisphosphate binding."; /evidence="ECO:0000269|PubMed:15359279"; MUTAGEN 274; /note="V->G: Increased phosphatidylinositol 3,4,5-trisphosphate binding."; /evidence="ECO:0000269|PubMed:15359279"; MUTAGEN 278; /note="K->A: Strongly reduces phosphatidylinositol 3,4,5-trisphosphate binding."; /evidence="ECO:0000269|PubMed:15359279"; MUTAGEN 280; /note="R->A: Abolishes phosphatidylinositol 3,4,5-trisphosphate binding."; /evidence="ECO:0000269|PubMed:15359279"; MUTAGEN 291; /note="Y->F: Abolishes phosphatidylinositol 3,4,5-trisphosphate binding."; /evidence="ECO:0000269|PubMed:15359279"; MUTAGEN 301; /note="R->A: Abolishes phosphatidylinositol 3,4,5-trisphosphate binding."; /evidence="ECO:0000269|PubMed:15359279"; MUTAGEN 339; /note="K->A: Abolishes phosphatidylinositol 3,4,5-trisphosphate binding."; /evidence="ECO:0000269|PubMed:15359279"; MUTAGEN 351; /note="H->A: Abolishes phosphatidylinositol 3,4,5-trisphosphate binding."; /evidence="ECO:0000269|PubMed:15359279
uniprot
proteins
pubmed
15359279
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18042453
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20080746
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25326380
uniprot
proteins
pubmed
9744817
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q99418}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99418}. Cytoplasm {ECO:0000269|PubMed:25326380}. Cell projection {ECO:0000269|PubMed:25326380}. Cell projection, growth cone {ECO:0000269|PubMed:25326380}. Cell junction, tight junction {ECO:0000269|PubMed:20080746}. Cell junction, adherens junction {ECO:0000269|PubMed:20080746}. Note=Recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. Also requires interaction with phosphoinositides for targeting to plasma membrane (By similarity). In differentiating neuroblastoma cells, colocalizes with CCDC120 in both neurite shaft and growth cone areas. {ECO:0000250, ECO:0000269|PubMed:25326380}.
uniprot
proteins