Rilpl1
entrez
304469
canonical
uniprot
D3ZUQ0
canonical
ensembl
ENSRNOG00000001055
resolver
ensembl
ENSRNOG00055013777
resolver
ensembl
ENSRNOG00060002797
resolver
ensembl
ENSRNOG00065006839
resolver
ensp
ENSRNOP00000001401
resolver
ensp
ENSRNOP00000072380
resolver
ensp
ENSRNOP00000082699
resolver
ensp
ENSRNOP00000087559
resolver
ensp
ENSRNOP00055019289
resolver
ensp
ENSRNOP00060003198
resolver
ensp
ENSRNOP00065007879
resolver
enst
ENSRNOT00000001401
resolver
enst
ENSRNOT00000090831
resolver
enst
ENSRNOT00000115532
resolver
enst
ENSRNOT00055023687
resolver
enst
ENSRNOT00060004504
resolver
enst
ENSRNOT00065010659
resolver
genesymbol
Rilpl1
resolver
uniprot
A0A0G2K2U5
resolver
uniprot
A0A8I5ZVF2
resolver
uniprot
A0A8L2PZW4
resolver
uniprot_entry
A0A0G2K2U5_RAT
resolver
uniprot_entry
A0A8I5ZVF2_RAT
resolver
uniprot_entry
A0A8L2PZW4_RAT
resolver
uniprot_entry
RIPL1_RAT
resolver
amino_acid_sequence
MEEPLGSPPAALSALEKNVAELTVMDVYDIASLVGHEFERVIDQHGCEAIARLMPKVVRVLEILEVLVSRHHVAPELDELRLELDRLRVERMDRIEKERKHQKELELVEDVWRGEAQDLLSQIAQLQEENKQLMTNLNHKDVGFSEEELQKHEGMSERERQVMKRLKEVVDKQRDEIRAKDRELVLKNEDVEALQQQQTRLMKINHDLRHRVTVVEAQGKALIEQKVELEADLQTKEQEMGSLRAELGKLRERLQGEHSQNGEEEEAEIPPQPDGEESISDAEKAALDLKDPNRPRFTLQELRDVLHERNELKSKVFLLQEELAYYKSEEIEEENRIPQPPPITHPRTSPQPESGIKRLFSFFSRDKRRLANTQRPTHIHESFGQWAITHRDDGYTEQGQEALQHL
uniprot
proteins
function
FUNCTION: Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (PubMed:19607794). Competes with SIAH1 for binding GAPDH (PubMed:19607794). Does not regulate lysosomal morphology and distribution (By similarity). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (By similarity). {ECO:0000250|UniProtKB:Q5EBL4, ECO:0000250|UniProtKB:Q9JJC6, ECO:0000269|PubMed:19607794}.
uniprot
proteins
mass_dalton
47330
uniprot
proteins
mutagenesis
MUTAGEN 47; /note="C->S: Abolishes S-nitrosylation and subsequent interaction with GAPDH."; /evidence="ECO:0000269|PubMed:19607794
uniprot
proteins
post_translational_modification
PTM: S-nitrosylation is required for the interaction with GAPDH. {ECO:0000269|PubMed:19607794}.
uniprot
proteins
protein_family
RILPL family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19607794
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
30398148
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19607794}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:30398148}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:30398148}.
uniprot
proteins