Ctdspl
entrez
69274
canonical
uniprot
P58465
canonical
ensembl
ENSMUSG00000047409
resolver
ensp
ENSMUSP00000072852
resolver
ensp
ENSMUSP00000133755
resolver
enst
ENSMUST00000073109
resolver
enst
ENSMUST00000172464
resolver
genesymbol
Ctdspl
resolver
genesymbol_syn
Nif1
resolver
genesymbol_syn
Nifl
resolver
uniprot
G3UXN0
resolver
uniprot
Q52KL5
resolver
uniprot_entry
CTDSL_MOUSE
resolver
uniprot_entry
G3UXN0_MOUSE
resolver
uniprot_sec
Q52KL5
resolver
amino_acid_sequence
MDGPAIITQVTNPKEDEARSPVAGEKASQRNISLKKQRGRSILSSFFCCFRDYNVEAPPANSPSVLPPLVEENGGLQKGDQRQVIPVPSPPAKYLLPEVTVLDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSREDDVYSMLHRLCSR
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
31156
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins