SDCBP
entrez
6386
canonical
uniprot
O00560
canonical
ensembl
ENSG00000137575
resolver
ensp
ENSP00000260130
resolver
ensp
ENSP00000395351
resolver
ensp
ENSP00000409288
resolver
ensp
ENSP00000411771
resolver
ensp
ENSP00000428184
resolver
ensp
ENSP00000430730
resolver
ensp
ENSP00000487245
resolver
ensp
ENSP00000541004
resolver
enst
ENST00000520168
resolver
enst
ENST00000523483
resolver
enst
ENST00000630925
resolver
genesymbol
SDCBP
resolver
genesymbol_syn
MDA9
resolver
genesymbol_syn
SYCL
resolver
hgnc
HGNC:10662
resolver
uniprot
B2R5Q7
resolver
uniprot
B4DHN5
resolver
uniprot
B4DUH3
resolver
uniprot
B7ZLN2
resolver
uniprot
F6XW56
resolver
uniprot
G5EA09
resolver
uniprot
O00173
resolver
uniprot
O43391
resolver
uniprot
Q14CP2
resolver
uniprot_entry
B4DHN5_HUMAN
resolver
uniprot_entry
F6XW56_HUMAN
resolver
uniprot_entry
G5EA09_HUMAN
resolver
uniprot_entry
SDCB1_HUMAN
resolver
uniprot_sec
B2R5Q7
resolver
uniprot_sec
B4DUH3
resolver
uniprot_sec
B7ZLN2
resolver
uniprot_sec
O00173
resolver
uniprot_sec
O43391
resolver
uniprot_sec
Q14CP2
resolver
amino_acid_sequence
MSLYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPIPHDGNLYPRLYPELSQYMGLSLNEEEIRANVAVVSGAPLQGQLVARPSSINYMVAPVTGNDVGIRRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMPAFIFEHIIKRMAPSIMKSLMDHTIPEV
uniprot
proteins
function
FUNCTION: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). {ECO:0000269|PubMed:10230395, ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:11498591, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:26539120, ECO:0000303|PubMed:26291527}.
uniprot
proteins
mass_dalton
32444
uniprot
proteins
mutagenesis
MUTAGEN 214; /note="K->A: Disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate. Impaired interaction with FZD7 and disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate; when associated with A-250."; /evidence="ECO:0000269|PubMed:27386966"; MUTAGEN 215; /note="N->D: Disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate."; /evidence="ECO:0000269|PubMed:27386966"; MUTAGEN 250; /note="K->A: Disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate. Impaired interaction with FZD7 and disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate; when associated with A-214."; /evidence="ECO:0000269|PubMed:27386966
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues.
uniprot
proteins
pubmed
10230395
uniprot
proteins
pubmed
10770943
uniprot
proteins
pubmed
11152476
uniprot
proteins
pubmed
11179419
uniprot
proteins
pubmed
11432873
uniprot
proteins
pubmed
11498591
uniprot
proteins
pubmed
12643545
uniprot
proteins
pubmed
12679023
uniprot
proteins
pubmed
12842047
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15081807
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16533050
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22660413
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25219541
uniprot
proteins
pubmed
25893292
uniprot
proteins
pubmed
26032692
uniprot
proteins
pubmed
26291527
uniprot
proteins
pubmed
26539120
uniprot
proteins
pubmed
27386966
uniprot
proteins
pubmed
9391086
uniprot
proteins
pubmed
9511750
uniprot
proteins
pubmed
9883737
uniprot
proteins
sequence_length
298
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:11179419}. Cell junction, adherens junction {ECO:0000269|PubMed:11179419}. Cell membrane {ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:27386966}; Peripheral membrane protein {ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:27386966}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065}. Nucleus {ECO:0000269|PubMed:11179419}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Cytoplasm, cytosol {ECO:0000269|PubMed:11179419}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11179419}. Secreted, extracellular exosome {ECO:0000269|PubMed:22660413}. Membrane raft {ECO:0000269|PubMed:25893292}. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:27386966). {ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:27386966}.
uniprot
proteins