Tle4
entrez
21888
canonical
uniprot
Q62441
canonical
ensembl
ENSMUSG00000024642
resolver
ensp
ENSMUSP00000057527
resolver
ensp
ENSMUSP00000169247
resolver
ensp
ENSMUSP00000169248
resolver
ensp
ENSMUSP00000169250
resolver
enst
ENSMUST00000052011
resolver
genesymbol
Tle4
resolver
genesymbol_syn
Grg4
resolver
uniprot
Q3UY41
resolver
uniprot
Q9JKQ9
resolver
uniprot_entry
Q3UY41_MOUSE
resolver
uniprot_entry
TLE4_MOUSE
resolver
uniprot_sec
Q9JKQ9
resolver
amino_acid_sequence
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGSEKHRNSTDYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKTRLLKKDAPISPASVASSSSTPSSKSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKPPGVDPLASSLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRSPVVGFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY
uniprot
proteins
function
FUNCTION: Transcriptional corepressor that binds to a number of transcription factors (PubMed:21317240). Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling (PubMed:10811620). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (PubMed:12050133). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (PubMed:23371388). {ECO:0000269|PubMed:10811620, ECO:0000269|PubMed:12050133, ECO:0000269|PubMed:21317240, ECO:0000269|PubMed:23371388}.
uniprot
proteins
mass_dalton
83787
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. PAX5 binding increases phosphorylation. {ECO:0000269|PubMed:10811620}.; PTM: Ubiquitinated by XIAP/BIRC4. {ECO:0000250}.
uniprot
proteins
protein_family
WD repeat Groucho/TLE family
uniprot
proteins
pubmed
10811620
uniprot
proteins
pubmed
11266540
uniprot
proteins
pubmed
12050133
uniprot
proteins
pubmed
16314515
uniprot
proteins
pubmed
18254933
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21317240
uniprot
proteins
pubmed
23371388
uniprot
proteins
pubmed
23990468
uniprot
proteins
pubmed
8892234
uniprot
proteins
sequence_length
773
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins