Kcnab2
entrez
16498
canonical
uniprot
P62482
canonical
ensembl
ENSMUSG00000028931
resolver
ensp
ENSMUSP00000030768
resolver
ensp
ENSMUSP00000101273
resolver
ensp
ENSMUSP00000124156
resolver
ensp
ENSMUSP00000124588
resolver
ensp
ENSMUSP00000125058
resolver
ensp
ENSMUSP00000158771
resolver
ensp
ENSMUSP00000158839
resolver
ensp
ENSMUSP00000267954
resolver
ensp
ENSMUSP00000267972
resolver
ensp
ENSMUSP00000267973
resolver
ensp
ENSMUSP00000267974
resolver
enst
ENSMUST00000030768
resolver
enst
ENSMUST00000105648
resolver
enst
ENSMUST00000159186
resolver
enst
ENSMUST00000159840
resolver
enst
ENSMUST00000160884
resolver
enst
ENSMUST00000238252
resolver
genesymbol
Kcnab2
resolver
genesymbol_syn
Ckbeta2
resolver
genesymbol_syn
I2rf5
resolver
genesymbol_syn
Kcnb3
resolver
uniprot
A0A571BF54
resolver
uniprot
E0CXZ9
resolver
uniprot
F6TS87
resolver
uniprot
P97381
resolver
uniprot
Q3UPV6
resolver
uniprot
Q60942
resolver
uniprot
Q64284
resolver
uniprot_entry
A0A571BF54_MOUSE
resolver
uniprot_entry
E0CXZ9_MOUSE
resolver
uniprot_entry
F6TS87_MOUSE
resolver
uniprot_entry
KCAB2_MOUSE
resolver
uniprot_entry
Q3UPV6_MOUSE
resolver
uniprot_sec
P97381
resolver
uniprot_sec
Q60942
resolver
uniprot_sec
Q64284
resolver
amino_acid_sequence
MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEIDSILGNKPYSKKDYRS
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
function
FUNCTION: Regulatory subunit of the voltage-gated potassium (Kv) Shaker channel family. Shaker channels are composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:8576199). The beta-2/KCNAB2 subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:8576199). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:8576199). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates (By similarity). Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet) (By similarity). The binding of oxidized and reduced nucleotide cofactors alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (PubMed:11825900, PubMed:21209188). {ECO:0000250|UniProtKB:P62483, ECO:0000269|PubMed:11825900, ECO:0000269|PubMed:21209188, ECO:0000269|PubMed:8576199}.
uniprot
proteins
mass_dalton
41021
uniprot
proteins
mutagenesis
MUTAGEN 90; /note="Y->F: No detectable phenotype."; /evidence="ECO:0000269|PubMed:11825900
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1. {ECO:0000250|UniProtKB:P62483}.
uniprot
proteins
protein_family
Shaker potassium channel beta subunit family
uniprot
proteins
pubmed
11825900
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15720404
uniprot
proteins
pubmed
1573677
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21209188
uniprot
proteins
pubmed
21357749
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
26269648
uniprot
proteins
pubmed
8576199
uniprot
proteins
pubmed
8824288
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62483}. Membrane {ECO:0000269|PubMed:21357749, ECO:0000269|PubMed:8576199}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P62483}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:11825900}. Synapse, synaptosome {ECO:0000269|PubMed:21357749}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P62483}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated. {ECO:0000250|UniProtKB:P62483}.
uniprot
proteins