PAPOLA
entrez
10914
canonical
uniprot
P51003
canonical
ensembl
ENSG00000090060
resolver
ensp
ENSP00000216277
resolver
ensp
ENSP00000376716
resolver
ensp
ENSP00000450437
resolver
ensp
ENSP00000450812
resolver
ensp
ENSP00000544142
resolver
ensp
ENSP00000544143
resolver
ensp
ENSP00000544144
resolver
ensp
ENSP00000544145
resolver
enst
ENST00000392990
resolver
enst
ENST00000557471
resolver
genesymbol
PAPOLA
resolver
genesymbol_syn
PAP
resolver
hgnc
HGNC:14981
resolver
uniprot
A0A0C4DGK1
resolver
uniprot
G3XAH6
resolver
uniprot
Q86SX4
resolver
uniprot
Q86TV0
resolver
uniprot
Q8IYF5
resolver
uniprot
Q9BVU2
resolver
uniprot_entry
A0A0C4DGK1_HUMAN
resolver
uniprot_entry
G3XAH6_HUMAN
resolver
uniprot_entry
PAPOA_HUMAN
resolver
uniprot_sec
Q86SX4
resolver
uniprot_sec
Q86TV0
resolver
uniprot_sec
Q8IYF5
resolver
uniprot_sec
Q9BVU2
resolver
amino_acid_sequence
MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQRRILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTSATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTDLSDIPALPANPIPVIKNSIKLRLNR
uniprot
proteins
ec_number
2.7.7.19
uniprot
proteins
function
FUNCTION: Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921, ECO:0000269|PubMed:8302877}.
uniprot
proteins
mass_dalton
82843
uniprot
proteins
post_translational_modification
PTM: Polysumoylated. Varying sumoylation depending on tissue- and cell-type. Highly sumoylated in bladder and NIH 3T3 cells. Sumoylation is required for nuclear localization and enhances PAP stability. Desumoylated by SENP1. Inhibits polymerase activity (By similarity). {ECO:0000250|UniProtKB:Q61183}.; PTM: Phosphorylated (PubMed:8302877). Hyperphosphorylation on multiple CDK2 consensus and non-consensus sites in the C-terminal Ser/Thr-rich region represses PAP activity in late M-phase (By similarity). Phosphorylation/dephosphorylation may regulate the interaction between PAP and CPSF (PubMed:8302877). {ECO:0000250|UniProtKB:P25500, ECO:0000269|PubMed:8302877}.; PTM: Acetylated in the C-terminus. Acetylation decreases interaction with NUDT21 and KPNB1, and inhibits nuclear localization through inhibiting binding to the importin alpha/beta complex (By similarity). {ECO:0000250|UniProtKB:P25500}.
uniprot
proteins
protein_family
Poly(A) polymerase family
uniprot
proteins
pubmed
14749727
uniprot
proteins
pubmed
15169763
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19224921
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8302877
uniprot
proteins
sequence_length
745
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8302877}. Nucleus {ECO:0000269|PubMed:8302877}. Note=The 90 kDa form is nuclear while the 100 kDa and the 106 kDa forms are both nuclear and cytoplasmic. {ECO:0000269|PubMed:8302877}.
uniprot
proteins