Lcn2
entrez
170496
canonical
uniprot
P30152
canonical
ensembl
ENSRNOG00000013973
resolver
ensembl
ENSRNOG00055006060
resolver
ensembl
ENSRNOG00060032897
resolver
ensembl
ENSRNOG00065024045
resolver
ensp
ENSRNOP00000018776
resolver
ensp
ENSRNOP00055007574
resolver
ensp
ENSRNOP00060047103
resolver
ensp
ENSRNOP00065033693
resolver
enst
ENSRNOT00000018776
resolver
enst
ENSRNOT00055009815
resolver
enst
ENSRNOT00060057023
resolver
enst
ENSRNOT00065041251
resolver
genesymbol
Lcn2
resolver
uniprot
Q5HZF1
resolver
uniprot_entry
NGAL_RAT
resolver
uniprot_sec
Q5HZF1
resolver
amino_acid_sequence
MGLGVLCLALVLLGVLQSQAQDSTQNLIPAPPLISVPLQPGFWTERFQGRWFVVGLAGNAVQKERQSRFTMYSTIYELQEDNSYNVTSILVRGQGCRYWIRTFVPSSRPGQFTLGNIHSYPQIQSYDVQVADTDYDQFAMVFFQKTSENKQYFKVTLYGRTKGLSDELKERFVSFAKSLGLKDNNIVFSVPTDQCIDN
uniprot
proteins
function
FUNCTION: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (By similarity). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tuberculosis (By similarity). {ECO:0000250|UniProtKB:P11672, ECO:0000250|UniProtKB:P80188}.
uniprot
proteins
mass_dalton
22476
uniprot
proteins
protein_family
Calycin superfamily
uniprot
proteins
protein_family
Lipocalin family
uniprot
proteins
pubmed
12453413
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21538546
uniprot
proteins
pubmed
2462726
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P80188}. Cytoplasmic granule lumen {ECO:0000250|UniProtKB:P80188}. Cytoplasmic vesicle lumen {ECO:0000250|UniProtKB:P80188}. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized (By similarity). Releases the bound iron in the acidic lumen of cytoplasmic vesicles (By similarity). {ECO:0000250|UniProtKB:P11672, ECO:0000250|UniProtKB:P80188}.
uniprot
proteins