Inhibition of host TYK2 by virus
uniprot_keyword
KW-1112
canonical
name
Inhibition of host TYK2 by virus
uniprot
definition
Viral protein involved in the evasion of the type I and III interferon pathways by inhibiting the host TYK2 protein. Upon viral infection, the TYK2 protein is activated by IFNalpha/beta or IFN-lambda stimulation leading to a series of phosphorylation events that induce transcription of several hundred IFN-responsive genes. Several viruses have evolved mechanisms to inhibit TYK2 activity thereby preventing the subsequent activation of downstream partners STAT1 and STAT2.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
uniprot_keywords
uniprot
keywords