TMED10
entrez
10972
canonical
uniprot
P49755
canonical
ensembl
ENSG00000170348
resolver
ensp
ENSP00000303145
resolver
genesymbol
TMED10
resolver
genesymbol_syn
TMP21
resolver
hgnc
HGNC:16998
resolver
uniprot
A0A024R6I3
resolver
uniprot
B2R605
resolver
uniprot
B4DL12
resolver
uniprot
G3V2K7
resolver
uniprot
Q15602
resolver
uniprot
Q16536
resolver
uniprot
Q53GF9
resolver
uniprot
Q86TC2
resolver
uniprot
Q86TS5
resolver
uniprot_entry
TMEDA_HUMAN
resolver
uniprot_sec
A0A024R6I3
resolver
uniprot_sec
B2R605
resolver
uniprot_sec
B4DL12
resolver
uniprot_sec
G3V2K7
resolver
uniprot_sec
Q15602
resolver
uniprot_sec
Q16536
resolver
uniprot_sec
Q53GF9
resolver
uniprot_sec
Q86TC2
resolver
uniprot_sec
Q86TS5
resolver
amino_acid_sequence
MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSMFCLIGLATWQVFYLRRFFKAKKLIE
uniprot
proteins
function
FUNCTION: Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi (PubMed:10052452, PubMed:11726511, PubMed:16641999, PubMed:17288597, PubMed:19296914, PubMed:20427317, PubMed:21219331, PubMed:27569046). The p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes (PubMed:10052452). Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation at the cytoplasmic side (PubMed:20427317, PubMed:27569046). Mainly functions in the early secretory pathway and cycles between the ER, ER-Golgi intermediate compartment (ERGIC) and Golgi, mediating cargo transport through COPI and COPII-coated vesicles (PubMed:10052452, PubMed:10852829, PubMed:12237308). In COPII vesicle-mediated anterograde transport, involved in the transport of GPI-anchored proteins by acting together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER (PubMed:20427317, PubMed:27569046). Recognizes GPI anchors structural remodeled in the ER by the GPI inositol-deacylase/PGAP1 and the metallophosphoesterase MPPE1/PGAP5 (By similarity). In COPI vesicle-mediated retrograde transport, involved in the biogenesis of COPI vesicles and vesicle coat recruitment (PubMed:11726511). Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent from the modulation of gamma-secretase activity) (PubMed:17288597). Involved in the KDELR2-mediated retrograde transport of the toxin A subunit (CTX-A-K63)together with COPI and the COOH terminus of KDELR2 (By similarity). On Golgi membranes, acts as a primary receptor for ARF1-GDP, a GTP-binding protein involved in COPI-vesicle formation (PubMed:11726511). Increases coatomer-dependent GTPase-activating activity of ARFGAP2 which mediates the hydrolysis of ARF1-bound GTP and therefore modulates protein trafficking from the Golgi apparatus (PubMed:19296914). Involved in the exocytic trafficking of G protein-coupled receptors F2LR1/PAR2 (trypsin and tryspin-like enzyme receptor), OPRM1 (opioid receptor) and P2RY4 (UTD and UDP receptor) from the Golgi to the plasma membrane, thus contributing to receptor resensitization (PubMed:21219331). In addition to its cargo receptor activity, may also act as a protein channel after oligomerization, facilitating the post-translational entry of leaderless cytoplasmic cargo into the ERGIC (PubMed:32272059). Involved in the translocation into ERGIC, the vesicle entry and the secretion of leaderless cargos (lacking the secretion signal sequence), including the mature form of interleukin 1/IL-1 family members, the alpha-crystallin B chain HSPB5, the carbohydrate-binding proteins galectin-1/LGALS1 and galectin-3/LGALS3, the microtubule-associated protein Tau/MAPT, and the annexin A1/ANXA1; the translocation process is dependent on cargo protein unfolding and enhanced by chaperones HSP90AB1 and HSP90B1/GRP9 (PubMed:32272059). Could also associates with the presenilin-dependent gamma-secretase complex in order to regulate gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40/Abeta40 (PubMed:16641999). {ECO:0000250|UniProtKB:Q28735, ECO:0000250|UniProtKB:Q63584, ECO:0000269|PubMed:10052452, ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:11726511, ECO:0000269|PubMed:12237308, ECO:0000269|PubMed:16641999, ECO:0000269|PubMed:17288597, ECO:0000269|PubMed:19296914, ECO:0000269|PubMed:20427317, ECO:0000269|PubMed:21219331, ECO:0000269|PubMed:27569046, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:10052452}.
uniprot
proteins
mass_dalton
24976
uniprot
proteins
mutagenesis
MUTAGEN 211..212; /note="FF->AA: No decrease in binding to COPG1. Disrupts interaction with SEC23A. Disrupts interaction with COPG1 and association with coatomer; when associated with 215-A-A-216."; /evidence="ECO:0000269|PubMed:10761932, ECO:0000269|PubMed:11056392, ECO:0000269|PubMed:9472029"; MUTAGEN 215..216; /note="KK->AA: Significant reduction in binding to COPG1. Disrupts interaction with COPG1 and association with coatomer; when associated with 211-A-A-212."; /evidence="ECO:0000269|PubMed:10761932, ECO:0000269|PubMed:11056392, ECO:0000269|PubMed:9472029
uniprot
proteins
protein_family
EMP24/GP25L family
uniprot
proteins
pubmed
10052452
uniprot
proteins
pubmed
10359607
uniprot
proteins
pubmed
10376215
uniprot
proteins
pubmed
10761932
uniprot
proteins
pubmed
10852829
uniprot
proteins
pubmed
11056392
uniprot
proteins
pubmed
11726511
uniprot
proteins
pubmed
12237308
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641999
uniprot
proteins
pubmed
16940185
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
17288597
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18287528
uniprot
proteins
pubmed
19296914
uniprot
proteins
pubmed
19837036
uniprot
proteins
pubmed
19892738
uniprot
proteins
pubmed
20427317
uniprot
proteins
pubmed
21219331
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21545355
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27569046
uniprot
proteins
pubmed
31455601
uniprot
proteins
pubmed
32272059
uniprot
proteins
pubmed
7596406
uniprot
proteins
pubmed
8663407
uniprot
proteins
pubmed
9382861
uniprot
proteins
pubmed
9472029
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308, ECO:0000269|PubMed:9472029}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:12237308, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:9382861}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308, ECO:0000269|PubMed:21219331, ECO:0000269|PubMed:9382861, ECO:0000269|PubMed:9472029}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:9382861}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q63584}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q63584}; Single-pass type I membrane protein {ECO:0000255}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.
uniprot
proteins
transmembrane_region
TRANSMEM 186..206; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins