Rab3ip
entrez
216363
canonical
uniprot
Q68EF0
canonical
ensembl
ENSMUSG00000064181
resolver
ensp
ENSMUSP00000020375
resolver
ensp
ENSMUSP00000151708
resolver
ensp
ENSMUSP00000290994
resolver
enst
ENSMUST00000020375
resolver
enst
ENSMUST00000219109
resolver
genesymbol
Rab3ip
resolver
genesymbol_syn
Rabin8
resolver
uniprot
A0A1W2P7K6
resolver
uniprot
Q8BR32
resolver
uniprot_entry
A0A1W2P7K6_MOUSE
resolver
uniprot_entry
Q8BR32_MOUSE
resolver
uniprot_entry
RAB3I_MOUSE
resolver
amino_acid_sequence
MANDPLEGFHEVNLASPTSPDLLGVCDPGTQEQTTSPSVIYRPHPSTLCAAPLQANALDLSDLPTQPVYSSPRHFNCAEVSNISAHAPDPASSVPSAVASGLTKLTSRKDSCNAEREFLQGATITEASAGNDDIFGLSTDSLSRLRSPSVLEVREKGYERLKEELAKAQREAHKMVREANVKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLAAAKTPFKRGHTRNKSTSSAMGGSHQDLSVIQPIVKDCKEADLSLYNEFRSWKDEPTMDRTCPFLDKIYQEDIFPCLTFAKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKPCRHRIRLGDSSCCYYISPFCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLRKEMSLAKLGYFKEEL
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation. {ECO:0000250|UniProtKB:Q96QF0}.
uniprot
proteins
mass_dalton
47133
uniprot
proteins
protein_family
SEC2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
428
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96QF0}. Nucleus {ECO:0000250|UniProtKB:Q96QF0}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q96QF0}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q96QF0}. Vesicle {ECO:0000250|UniProtKB:Q96QF0}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q96QF0}. Note=Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. {ECO:0000250|UniProtKB:Q96QF0}.
uniprot
proteins