PIK3C3
entrez
5289
canonical
uniprot
Q8NEB9
canonical
ensembl
ENSG00000078142
resolver
ensp
ENSP00000262039
resolver
ensp
ENSP00000381845
resolver
ensp
ENSP00000699521
resolver
ensp
ENSP00000741915
resolver
enst
ENST00000262039
resolver
enst
ENST00000398870
resolver
genesymbol
PIK3C3
resolver
genesymbol_syn
VPS34
resolver
hgnc
HGNC:8974
resolver
uniprot
A8MYT4
resolver
uniprot
B4DPV9
resolver
uniprot
Q15134
resolver
uniprot_entry
A8MYT4_HUMAN
resolver
uniprot_entry
B4DPV9_HUMAN
resolver
uniprot_entry
PK3C3_HUMAN
resolver
uniprot_sec
Q15134
resolver
amino_acid_sequence
MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
uniprot
proteins
ec_number
2.7.1.137
uniprot
proteins
function
FUNCTION: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435, PubMed:33993848). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). {ECO:0000250|UniProtKB:O88763, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:32690950, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:33993848, ECO:0000269|PubMed:7628435}.; FUNCTION: (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}.
uniprot
proteins
mass_dalton
101549
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated via 'Lys-29'- and 'Lys-48'-linked ubiquitination by UBE3C, promoting its degradation (PubMed:33637724). Deubiquitination by ZRANB1/TRABID promotes its stabilization, leading to autophagosome maturation (PubMed:33637724). {ECO:0000269|PubMed:33637724}.
uniprot
proteins
protein_family
PI3/PI4-kinase family
uniprot
proteins
pubmed
14617358
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16417406
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19050071
uniprot
proteins
pubmed
19270696
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20208530
uniprot
proteins
pubmed
20643123
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22493499
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23878393
uniprot
proteins
pubmed
23954414
uniprot
proteins
pubmed
25490155
uniprot
proteins
pubmed
31806350
uniprot
proteins
pubmed
32690950
uniprot
proteins
pubmed
32929276
uniprot
proteins
pubmed
33473107
uniprot
proteins
pubmed
33637724
uniprot
proteins
pubmed
33993848
uniprot
proteins
pubmed
34320401
uniprot
proteins
pubmed
7628435
uniprot
proteins
sequence_length
887
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Midbody {ECO:0000269|PubMed:20208530}. Late endosome {ECO:0000269|PubMed:14617358}. Cytoplasmic vesicle, autophagosome {ECO:0000305|PubMed:14617358}. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358). Also localizes to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:Q6PF93, ECO:0000305|PubMed:14617358}.
uniprot
proteins