Q91Y55
uniprot
Q91Y55
canonical
amino_acid_sequence
MKDLLQYAACFLAIFSTGFLIVATRTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGIRTCDEYDSIYAEHPLKLVVTRALMITADILAGFGFITLLLGLDCVKFLPDEPHIKVRLCFVAGTVLLIAGTPGIIGSVWYAVDVYVERSSLVLHNIFLGIQYKFGWSCWLGMAGSLGCFLAGALLTCCLYLFKDVGPERNYPYAMRKPYSTAGVSMAKSYKAPRTETAKMYAVDTRV
uniprot
proteins
function
FUNCTION: Forms paracellular channels: coassembles with CLDN19 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (By similarity) (PubMed:15496416). Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption (By similarity). {ECO:0000250|UniProtKB:Q925N4, ECO:0000250|UniProtKB:Q9Y5I7, ECO:0000269|PubMed:15496416}.
uniprot
proteins
mass_dalton
26091
uniprot
proteins
mutagenesis
MUTAGEN 233; /note="T->A: Loss of interaction with TJP1. Retains localization at the lateral plasma membrane but does not anchor at the tight junction."; /evidence="ECO:0000269|PubMed:15496416"; MUTAGEN 234; /note="R->A: No effect."; /evidence="ECO:0000269|PubMed:15496416"; MUTAGEN 235; /note="V->A: Loss of interaction with TJP1. Retains localization at the lateral plasma membrane but does not anchor at the tight junction."; /evidence="ECO:0000269|PubMed:15496416
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
11729235
uniprot
proteins
pubmed
15496416
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:15496416}. Cell membrane {ECO:0000269|PubMed:15496416}; Multi-pass membrane protein {ECO:0000255}. Note=Cotrafficks with CLDN19 from ER to tight junctions. {ECO:0000250|UniProtKB:Q9Y5I7}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 80..100; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins