BARD1
entrez
580
canonical
uniprot
Q99728
canonical
ensembl
ENSG00000138376
resolver
ensp
ENSP00000260947
resolver
ensp
ENSP00000392245
resolver
ensp
ENSP00000480470
resolver
ensp
ENSP00000482293
resolver
ensp
ENSP00000484464
resolver
ensp
ENSP00000585625
resolver
ensp
ENSP00000777491
resolver
enst
ENST00000421162
resolver
enst
ENST00000613374
resolver
enst
ENST00000619009
resolver
genesymbol
BARD1
resolver
hgnc
HGNC:952
resolver
uniprot
A0A087WZ19
resolver
uniprot
A0A087X1U2
resolver
uniprot
A0AVN2
resolver
uniprot
C9IYG1
resolver
uniprot
F6MDH7
resolver
uniprot
F6MDH8
resolver
uniprot
F6MDH9
resolver
uniprot
F6MDI0
resolver
uniprot
F6MDI1
resolver
uniprot
F6MDI2
resolver
uniprot
O43574
resolver
uniprot
Q53SS5
resolver
uniprot_entry
A0A087WZ19_HUMAN
resolver
uniprot_entry
A0A087X1U2_HUMAN
resolver
uniprot_entry
A0AVN2_HUMAN
resolver
uniprot_entry
BARD1_HUMAN
resolver
uniprot_entry
C9IYG1_HUMAN
resolver
uniprot_entry
F6MDI0_HUMAN
resolver
uniprot_entry
F6MDI1_HUMAN
resolver
uniprot_entry
F6MDI2_HUMAN
resolver
uniprot_sec
F6MDH7
resolver
uniprot_sec
F6MDH8
resolver
uniprot_sec
F6MDH9
resolver
uniprot_sec
O43574
resolver
uniprot_sec
Q53SS5
resolver
amino_acid_sequence
MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. {ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:20351172}.
uniprot
proteins
mass_dalton
86648
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Processed during apoptosis. The homodimer is more susceptible to proteolytic cleavage than the BARD1/BRCA1 heterodimer.
uniprot
proteins
pubmed
10026184
uniprot
proteins
pubmed
10477523
uniprot
proteins
pubmed
11573085
uniprot
proteins
pubmed
12890688
uniprot
proteins
pubmed
14976165
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17550235
uniprot
proteins
pubmed
17643122
uniprot
proteins
pubmed
18089818
uniprot
proteins
pubmed
18480049
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18842000
uniprot
proteins
pubmed
19261749
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20351172
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
8944023
uniprot
proteins
pubmed
9425226
uniprot
proteins
sequence_length
777
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Note=During S phase of the cell cycle, colocalizes with BRCA1 into discrete subnuclear foci. Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex.
uniprot
proteins