Rab3ip
entrez
29885
canonical
uniprot
Q62739
canonical
ensembl
ENSRNOG00000005362
resolver
ensembl
ENSRNOG00055012895
resolver
ensembl
ENSRNOG00060008450
resolver
ensembl
ENSRNOG00065012906
resolver
ensp
ENSRNOP00000007258
resolver
ensp
ENSRNOP00000079240
resolver
ensp
ENSRNOP00000091358
resolver
ensp
ENSRNOP00055017926
resolver
ensp
ENSRNOP00060010814
resolver
ensp
ENSRNOP00065016293
resolver
enst
ENSRNOT00000007258
resolver
enst
ENSRNOT00000109052
resolver
enst
ENSRNOT00000118552
resolver
enst
ENSRNOT00055022084
resolver
enst
ENSRNOT00060014115
resolver
enst
ENSRNOT00065021125
resolver
genesymbol
Rab3ip
resolver
genesymbol_syn
Rabin3
resolver
genesymbol_syn
Rabin8
resolver
uniprot
A0A8I5ZML7
resolver
uniprot
A0A8I6AR50
resolver
uniprot
A1L127
resolver
uniprot_entry
A0A8I5ZML7_RAT
resolver
uniprot_entry
A0A8I6AR50_RAT
resolver
uniprot_entry
RAB3I_RAT
resolver
uniprot_sec
A1L127
resolver
amino_acid_sequence
MANDPLEGFHEVNLASPTSPDLLGVCDPGTQEQTTSPSVIYRPHPSTLCSATIQANALNLSDLPTQPVYSSPRHLNCAEISNISIHVPEPASSVASEVAAGLTRFTSRKDSCNAEREFLQGATVTEASAGNDDIFGLSTDSLSRLRSPSVLEVREKGYERLKEELAKAQRELKLKDEECERLSKVRDQLGQELEELTASLFEEAHKMVREANVKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLAAGKTPFKRGHTRNKSTSSAMSGSHQDFSAIQPIVKDCREADLSLYNEFRSWKDEPTMDRTCPFLDKIYQEDIFPCLTFAKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKPCKHRIKLGDSSSYYYISPVCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLRKEMSLAKLGYFKEEL
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (By similarity). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Together with RAB11A and FIP3/RAB11FIP3, parts of the ciliary targeting complex that promotes preciliary vesicle trafficking to mother centriole and ciliogenesis initiation. Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (By similarity). {ECO:0000250|UniProtKB:Q96QF0, ECO:0000269|PubMed:12221131}.
uniprot
proteins
mass_dalton
51032
uniprot
proteins
protein_family
SEC2 family
uniprot
proteins
pubmed
12221131
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7532276
uniprot
proteins
sequence_length
460
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7532276}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin (By similarity). {ECO:0000250}.
uniprot
proteins