F11r
entrez
16456
canonical
uniprot
O88792
canonical
ensembl
ENSMUSG00000038235
resolver
ensp
ENSMUSP00000041907
resolver
enst
ENSMUST00000043839
resolver
genesymbol
F11r
resolver
genesymbol_syn
Jam1
resolver
genesymbol_syn
Jcam
resolver
genesymbol_syn
Jcam1
resolver
uniprot
Q8VC39
resolver
uniprot_entry
JAM1_MOUSE
resolver
uniprot_sec
Q8VC39
resolver
amino_acid_sequence
MGTEGKAGRKLLFLFTSMILGSLVQGKGSVYTAQSDVQVPENESIKLTCTYSGFSSPRVEWKFVQGSTTALVCYNSQITAPYADRVTFSSSGITFSSVTRKDNGEYTCMVSEEGGQNYGEVSIHLTVLVPPSKPTISVPSSVTIGNRAVLTCSEHDGSPPSEYSWFKDGISMLTADAKKTRAFMNSSFTIDPKSGDLIFDPVTAFDSGEYYCQAQNGYGTAMRSEAAHMDAVELNVGGIVAAVLVTLILLGLLIFGVWFAYSRGYFERTKKGTAPGKKVIYSQPSTRSEGEFKQTSSFLV
uniprot
proteins
function
FUNCTION: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11447115). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (PubMed:11447115). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (PubMed:9660867). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (By similarity). Involved in platelet activation (By similarity). {ECO:0000250|UniProtKB:Q9Y624, ECO:0000269|PubMed:11447115, ECO:0000269|PubMed:9660867}.
uniprot
proteins
mass_dalton
32424
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
11036763
uniprot
proteins
pubmed
11447115
uniprot
proteins
pubmed
11500366
uniprot
proteins
pubmed
12810109
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9660867
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:11036763}. Cell membrane {ECO:0000269|PubMed:11036763}; Single-pass type I membrane protein {ECO:0000269|PubMed:11036763}. Note=Localized at tight junctions of both epithelial and endothelial cells.
uniprot
proteins
transmembrane_region
TRANSMEM 239..259; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins