Gdpd2
entrez
71584
canonical
uniprot
Q9ESM6
canonical
ensembl
ENSMUSG00000019359
resolver
ensp
ENSMUSP00000019503
resolver
ensp
ENSMUSP00000109373
resolver
ensp
ENSMUSP00000267260
resolver
enst
ENSMUST00000019503
resolver
enst
ENSMUST00000113744
resolver
genesymbol
Gdpd2
resolver
genesymbol_syn
Gde3
resolver
genesymbol_syn
Obdpf
resolver
uniprot_entry
GDE3_MOUSE
resolver
amino_acid_sequence
MADSPGCCSIWARCLHCLYSCHWRKYPKQKMQTSKCDCIWFGLLFLTFLLSLGWLYIGLILLNDLHNFNEFLFRHWGHWMDWSLIVLLVVSLLVTYASLLLLLGLLLQLCGQPLHLHSLHKVLLLLIVLLVAAGLVGLDIQWRQEWHSLRLSLQATAPFLHIGAVAGITLLAWPVADTFYRIHPRGPKVLLLLLFFGVTLVIYLMPLLFISSPCIMKLRDLPPKPGLVGHRGAPMLAPENTLMSLRKTAECGAAVFETDVMVSSDGVPFLMHDERLSRTTNVASVFPERISAHSSDFSWAELQRLNAGTWFLERQPFWGAKKLSGSDRKEAENQTIPALEELLKEAAALNLSIMFDLRRPPRNHTYYDTFVNQTLEAVLSANVSQAMVLWLPDEDRANVQQRAPRMRQIYGHQGGNWTERPQFLNLPYQDLPALDIKALHQDNISVNLFVVNKPWLFSLLWCAGVDSVTTNACQLLQQMQNPLWLLPPQKYLMIWVITDCASILLLLSIFLLRGGCAKRNRTGLETAVLLTKINNFASE
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
ec_number
3.1.4.43
uniprot
proteins
function
FUNCTION: Calcium-dependent ecto-phospholipase C that cleaves the phosphodiester bond between the glycerol backbone and phosphate group of glycerophospholipids at the cell surface, regulating multiple signaling pathways (PubMed:19596859, PubMed:32629025, PubMed:32917725). Substrates include GPI-anchored proteins, which are released from the membrane upon cleavage of the inositol-phosphate linkage. For example, cleavage and release of UPAR/PLAUR regulates cell-matrix adhesion and extracellular matrix remodeling. Also cleaves the glycosylphosphatidylinositol (GPI) anchor of metalloproteases TRABD2A and TRABD2B, releasing them from the plasma membrane. This release modulates their regulation of Wnt signaling. Also hydrolyzes lysophosphatidylinositol (LPI) to monoacylglycerol and inositol-1-phosphate (By similarity). Also hydrolyzes lysophosphatidylinositol (LPI) to monoacylglycerol and inositol-1-phosphate. Converts 2-arachidonoyl-LPI, the endogenous GPR55 agonist, into 2-arachidonoylglycerol (2-AG), an endocannabinoid that activates CNR1/CNR2. Thereby, acts as a switch redirecting signaling from GPR55 to CNR1/CNR2 within the endocannabinoid system that could alternatively regulate osteoblast proliferation and differentiation (PubMed:12933806, PubMed:32629025, PubMed:32917725). Can also cleave glycerophosphoinositol to glycerol and inositol-1-phosphate in vitro (PubMed:19596859). May also play a role in remodeling of the actin cytoskeleton (PubMed:12933806, PubMed:19596859). {ECO:0000250|UniProtKB:Q9HCC8, ECO:0000269|PubMed:12933806, ECO:0000269|PubMed:19596859, ECO:0000269|PubMed:32629025, ECO:0000269|PubMed:32917725}.
uniprot
proteins
mass_dalton
61165
uniprot
proteins
mutagenesis
MUTAGEN 231; /note="R->A: Loss of phosphoric diester hydrolase activity."; /evidence="ECO:0000269|PubMed:19596859
uniprot
proteins
protein_family
Glycerophosphoryl diester phosphodiesterase family
uniprot
proteins
pubmed
12933806
uniprot
proteins
pubmed
15276213
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19596859
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32629025
uniprot
proteins
pubmed
32917725
uniprot
proteins
sequence_length
539
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12933806}; Multi-pass membrane protein {ECO:0000269|PubMed:12933806}. Note=Colocalizes with the actin cytoskeleton. {ECO:0000269|PubMed:12933806}.
uniprot
proteins
transmembrane_region
TRANSMEM 41..61; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 122..142; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 492..512; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins