Trpc7
entrez
26946
canonical
uniprot
Q9WVC5
canonical
ensembl
ENSMUSG00000021541
resolver
ensp
ENSMUSP00000022023
resolver
ensp
ENSMUSP00000105497
resolver
ensp
ENSMUSP00000133305
resolver
ensp
ENSMUSP00000133411
resolver
ensp
ENSMUSP00000259952
resolver
ensp
ENSMUSP00000259953
resolver
enst
ENSMUST00000022023
resolver
enst
ENSMUST00000109871
resolver
genesymbol
Trpc7
resolver
genesymbol_syn
Trp7
resolver
genesymbol_syn
Trrp8
resolver
uniprot
E9PVJ9
resolver
uniprot
Q0VFY2
resolver
uniprot
Q3UXW9
resolver
uniprot_entry
E9PVJ9_MOUSE
resolver
uniprot_entry
Q0VFY2_MOUSE
resolver
uniprot_entry
Q3UXW9_MOUSE
resolver
uniprot_entry
TRPC7_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by diacylglycerol (DAG), independently of protein kinase C. {ECO:0000269|PubMed:10488066}.
uniprot
proteins
amino_acid_sequence
MLGSNTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILSHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNLQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGQTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKASEAQLYVDQYVQDVTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIELCQSKAKRCENDLEMGMLNSKFRKTRYQAGMRNSENLTANSTFSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNQGKDI
uniprot
proteins
function
FUNCTION: Non-selective, calcium-permeable cation channel (PubMed:10488066). Also transports maganese (PubMed:10488066). Contributes to both spontaneous and receptor stimulation-induced cationic currents (PubMed:10488066). Receptor stimulation, including that of G(q)-coupled or receptor tyrosine kinase pathways, triggers phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositides, producing diacylglycerol (DAG) that activates TRPC7 (PubMed:10488066, PubMed:22051675). May also be activated by depletion of intracellular calcium stores (PubMed:10488066). Mediates depolarization of intrinsically photosensitive retinal ganglion cells (ipRGCs) in response to light-induced melanopsin (OPN4)-mediated phototransduction via G(q)-PLC signaling, likely by forming heteromeric TRPC6-TRPC7 channels (PubMed:22051675). {ECO:0000269|PubMed:10488066, ECO:0000269|PubMed:22051675}.
uniprot
proteins
mass_dalton
99475
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity. {ECO:0000250|UniProtKB:Q9HCX4}.
uniprot
proteins
protein_family
STrpC subfamily
uniprot
proteins
protein_family
TRPC7 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
10488066
uniprot
proteins
pubmed
22051675
uniprot
proteins
sequence_length
862
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9HCX4}; Multi-pass membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000250|UniProtKB:Q9HCX4}.
uniprot
proteins
transmembrane_region
TRANSMEM 352..372; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 384..404; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 466..486; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 538..558; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 582..602; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 652..672; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins