Atox1
entrez
11927
canonical
uniprot
O08997
canonical
ensembl
ENSMUSG00000018585
resolver
ensp
ENSMUSP00000104485
resolver
enst
ENSMUST00000108857
resolver
genesymbol
Atox1
resolver
uniprot
Q5NCU2
resolver
uniprot_entry
ATOX1_MOUSE
resolver
uniprot_sec
Q5NCU2
resolver
amino_acid_sequence
MPKHEFSVDMTCEGCAEAVSRVLNKLGGVEFNIDLPNKKVCIDSEHSSDTLLATLNKTGKAVSYLGPK
uniprot
proteins
function
FUNCTION: Multifunctional copper-sensing protein that operates both as a cytosolic copper chaperone and as a copper-dependent transcription factor. Essential for maintaining cellular copper homeostasis and linking copper distribution to redox balance, signal transduction, and gene regulation (PubMed:11391006, PubMed:15761197, PubMed:26437801, PubMed:27666810). In the cytosol, transfers copper to the copper-transporting ATPase ATP7A at the trans-Golgi network, which is required for activation of secretory copper enzymes including lysyl oxidase (LOX) and SOD3. This chaperone function is essential for full SOD3 and LOX enzymatic activity (PubMed:11391006, PubMed:15761197, PubMed:26437801, PubMed:27666810). Acts as a copper-dependent transcription factor. Upon copper binding, translocates to the nucleus where it binds specific promoter elements and regulates transcription of genes involved in cell proliferation, oxidative stress defense, and extracellular matrix remodeling. Activates expression of target genes including CCND1, SOD3 and NCF1, thereby linking cellular copper status to gene expression programs controlling growth and redox homeostasis (PubMed:15761197, PubMed:26437801, PubMed:27666810). {ECO:0000269|PubMed:11391006, ECO:0000269|PubMed:15761197, ECO:0000269|PubMed:26437801, ECO:0000269|PubMed:27666810}.
uniprot
proteins
mass_dalton
7338
uniprot
proteins
protein_family
ATX1 family
uniprot
proteins
pubmed
10673341
uniprot
proteins
pubmed
11391006
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15761197
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
26437801
uniprot
proteins
pubmed
27666810
uniprot
proteins
sequence_length
68
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:27666810}. Nucleus {ECO:0000269|PubMed:27666810}. Note=Primarily cytoplasmic; translocates to the nucleus in a copper- and stimulus-dependent manner. {ECO:0000269|PubMed:27666810}.
uniprot
proteins