Pla2g5
entrez
29354
canonical
uniprot
P51433
canonical
ensembl
ENSRNOG00000016838
resolver
ensembl
ENSRNOG00055022859
resolver
ensembl
ENSRNOG00060031903
resolver
ensembl
ENSRNOG00065021857
resolver
ensp
ENSRNOP00000107135
resolver
ensp
ENSRNOP00055031836
resolver
ensp
ENSRNOP00060045766
resolver
ensp
ENSRNOP00065030023
resolver
enst
ENSRNOT00055039251
resolver
enst
ENSRNOT00060055322
resolver
enst
ENSRNOT00065037215
resolver
genesymbol
Pla2g5
resolver
uniprot
Q6DQ96
resolver
uniprot_entry
PA2G5_RAT
resolver
uniprot_sec
Q6DQ96
resolver
amino_acid_sequence
MKRLLTLAWFLACSVPAVPGGLLELKSMIEKVTGKNAVKNYGFYGCYCGWGGHGTPKDGTDWCCRMHDRCYGLLEEKHCAIRTQSYDYRFTQDLVICEHDSFCPVRLCACDRKLVYCLRRNLWSYNRLYQYYPNFLC
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups (By similarity). Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype (By similarity). May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of cardiolipin, a major component of the inner membrane of mitochondria and bacterial membranes. Promotes phagocytosis of bacteria in macrophages through production of lysophosphatidylethanolamines. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (By similarity). Promotes phagocytosis and killing of ingested fungi likely through controlling phagosome-lysosome fusion and phagosome maturation (By similarity). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells. In eosinophils, triggers perinuclear arachidonate release and LTC4 synthesis in a PLA2G4A-independent way. In neutrophils, amplifies CysLTs biosynthesis initiated by PLA2G4A (By similarity). Promotes immune complex clearance in macrophages via stimulating synthesis of CysLTs, which act through CYSLTR1 to trigger phagocytosis. May regulate antigen processing in antigen-presenting cells. In pulmonary macrophages regulates IL33 production required for activation of group 2 innate lymphoid cells (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). {ECO:0000250|UniProtKB:P39877, ECO:0000250|UniProtKB:P97391}.
uniprot
proteins
mass_dalton
15996
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000250|UniProtKB:P39877}.; PATHWAY: Lipid metabolism; leukotriene B4 biosynthesis. {ECO:0000250|UniProtKB:P39877}.; PATHWAY: Lipid metabolism; leukotriene C4 biosynthesis. {ECO:0000250|UniProtKB:P39877}.
uniprot
proteins
post_translational_modification
PTM: This enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins.
uniprot
proteins
protein_family
Phospholipase A2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7947992
uniprot
proteins
sequence_length
137
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P97391}. Cell membrane {ECO:0000250|UniProtKB:P97391}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P97391}. Recycling endosome {ECO:0000250|UniProtKB:P97391}. Golgi apparatus, cis-Golgi network {ECO:0000250|UniProtKB:P97391}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P97391}.
uniprot
proteins