FAM170A
entrez
340069
canonical
uniprot
A1A519
canonical
ensembl
ENSG00000164334
resolver
ensp
ENSP00000334285
resolver
ensp
ENSP00000368873
resolver
ensp
ENSP00000511971
resolver
genesymbol
FAM170A
resolver
genesymbol_syn
ZNFD
resolver
hgnc
HGNC:27963
resolver
uniprot
Q66LM8
resolver
uniprot
Q7Z4V2
resolver
uniprot
Q8IW94
resolver
uniprot_entry
F170A_HUMAN
resolver
uniprot_sec
Q66LM8
resolver
uniprot_sec
Q7Z4V2
resolver
uniprot_sec
Q8IW94
resolver
amino_acid_sequence
MKRRQKRKHLENEESQETAEKGGGMSKSQEDALQPGSTRVAKGWSQGVGEVTSTSEYCSCVSSSRKLIHSGIQRIHRDSPQPQSPLAQVQERGETPPRSQHVSLSSYSSYKTCVSSLCVNKEERGMKIYYMQVQMNKGVAVSWETEETLESLEKQPRMEEVTLSEVVRVGTPPSDVSTRNLLSDSEPSGEEKEHEERTESDSLPGSPTVEDTPRAKTPDWLVTMENGFRCMACCRVFTTMEALQEHVQFGIREGFSCHVFHLTMAQLTGNMESESTQDEQEEENGNEKEEEEKPEAKEEEGQPTEEDLGLRRSWSQCPGCVFHSPKDRNS
uniprot
proteins
function
FUNCTION: Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes (PubMed:20162441). Binds to heat shock promoter elements (HSE) (PubMed:20162441). Necessary for normal sperm head morphology, efficient spermiation, and sperm progressive motility (By similarity). Plays a crucial role in sperm chromatin remodeling by promoting the nuclear translocation and deubiquitinating activity of USP7 on histone H2A and H2B variants (By similarity). This ensures the timely removal of core histones, proper expression and degradation of transition proteins, and efficient incorporation of protamines during spermiogenesis (By similarity). {ECO:0000250|UniProtKB:Q66LM6, ECO:0000269|PubMed:20162441}.
uniprot
proteins
mass_dalton
37158
uniprot
proteins
protein_family
FAM170 family
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20162441
uniprot
proteins
pubmed
39868537
uniprot
proteins
sequence_length
330
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20162441, ECO:0000269|PubMed:39868537}.
uniprot
proteins