STK38L
entrez
23012
canonical
uniprot
Q9Y2H1
canonical
ensembl
ENSG00000211455
resolver
ensp
ENSP00000373684
resolver
genesymbol
STK38L
resolver
genesymbol_syn
KIAA0965
resolver
genesymbol_syn
NDR2
resolver
hgnc
HGNC:17848
resolver
uniprot
A8K4U0
resolver
uniprot
B4E3J8
resolver
uniprot
Q8TBX7
resolver
uniprot_entry
ST38L_HUMAN
resolver
uniprot_sec
A8K4U0
resolver
uniprot_sec
B4E3J8
resolver
uniprot_sec
Q8TBX7
resolver
activity_regulation
ACTIVITY REGULATION: Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L. {ECO:0000269|PubMed:15037617, ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:16314523}.
uniprot
proteins
amino_acid_sequence
MAMTAGTTTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Involved in the regulation of structural processes in differentiating and mature neuronal cells. {ECO:0000250, ECO:0000269|PubMed:15037617, ECO:0000269|PubMed:15067004}.
uniprot
proteins
mass_dalton
54003
uniprot
proteins
mutagenesis
MUTAGEN 75; /note="T->A: Decreased kinase activity. Reduced binding of S100B."; /evidence="ECO:0000269|PubMed:15037617"; MUTAGEN 119; /note="K->A: Loss of autophosphorylation and kinase activity."; /evidence="ECO:0000269|PubMed:15037617"; MUTAGEN 282; /note="S->A: Loss of autophosphorylation and kinase activity."; /evidence="ECO:0000269|PubMed:15037617"; MUTAGEN 442; /note="T->A: Decreased kinase activity."; /evidence="ECO:0000269|PubMed:15037617
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15037617
uniprot
proteins
pubmed
15067004
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16314523
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Note=Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.
uniprot
proteins