Trim29
entrez
72169
canonical
uniprot
Q8R2Q0
canonical
ensembl
ENSMUSG00000032013
resolver
ensp
ENSMUSP00000034511
resolver
enst
ENSMUST00000034511
resolver
genesymbol
Trim29
resolver
uniprot
Q8CEE2
resolver
uniprot
Q922Y3
resolver
uniprot
Q99PN5
resolver
uniprot
Q9CSC9
resolver
uniprot_entry
TRI29_MOUSE
resolver
uniprot_sec
Q8CEE2
resolver
uniprot_sec
Q922Y3
resolver
uniprot_sec
Q99PN5
resolver
uniprot_sec
Q9CSC9
resolver
amino_acid_sequence
MEGADACRSNGASPEARDTRSPPGPSGSLENGTKADSKDTKTTNGHSGEVTEGKTLGSALKSGEGKSGLFSSNEWRRPIIQFVESVDDKGSSYFSMDSAEGRRSPYAGLQLGASKKPPVTFAEKGELRKSIFSEPRKPTVTIVEPGEVRRNSYPRADSSLLARAKSGSEEVLCDSCIGNKQKAVKSCLVCQASFCELHLKPHLEGAAFRDHQLLEPIRDFEARKCPLHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKEQLQLKIIEIEDDVEKWQKEKDRIKSFTTNEKAILEQNFRDLVRELEKQKEEVRAALEQREQDAVDQVKVIVDALDERAKVLHEDKQTREQLHNISDSVLFLQEFGALMSNYSLPPPLPTYHVLLEGEGLGQSLGNCKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRYMNSYTSSYGNEWSTPDTMKRYSMYLTPKGGGRTSYQPSSPSRLSKETNQKNFNNLYGTKGNYTSRVWEYTSTVQNSEDMPTVQGNSSFSLKGFPSLLRSQVPKAQPQTWKSGKQTLLSHYRPFYVNKGSGIGSNEAP
uniprot
proteins
function
FUNCTION: Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. {ECO:0000250|UniProtKB:Q14134}.
uniprot
proteins
mass_dalton
65820
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27695001
uniprot
proteins
sequence_length
587
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14134}. Lysosome {ECO:0000250|UniProtKB:Q14134}. Note=Colocalizes with intermediate filaments. {ECO:0000250|UniProtKB:Q14134}.
uniprot
proteins