EPHX3
entrez
79852
canonical
uniprot
Q9H6B9
canonical
ensembl
ENSG00000105131
resolver
ensp
ENSP00000221730
resolver
ensp
ENSP00000410323
resolver
ensp
ENSP00000469345
resolver
ensp
ENSP00000521245
resolver
ensp
ENSP00000521246
resolver
ensp
ENSP00000585379
resolver
ensp
ENSP00000585380
resolver
ensp
ENSP00000585381
resolver
ensp
ENSP00000585382
resolver
ensp
ENSP00000585383
resolver
ensp
ENSP00000585384
resolver
ensp
ENSP00000585385
resolver
ensp
ENSP00000585386
resolver
ensp
ENSP00000585387
resolver
ensp
ENSP00000585388
resolver
ensp
ENSP00000585389
resolver
enst
ENST00000221730
resolver
enst
ENST00000435261
resolver
enst
ENST00000602233
resolver
enst
ENST00000851186
resolver
enst
ENST00000851188
resolver
enst
ENST00000915320
resolver
enst
ENST00000915321
resolver
enst
ENST00000915322
resolver
enst
ENST00000915323
resolver
enst
ENST00000915324
resolver
enst
ENST00000915325
resolver
enst
ENST00000915326
resolver
enst
ENST00000915327
resolver
enst
ENST00000915328
resolver
enst
ENST00000915329
resolver
enst
ENST00000915330
resolver
genesymbol
EPHX3
resolver
genesymbol_syn
ABHD9
resolver
hgnc
HGNC:23760
resolver
uniprot
A3KMR3
resolver
uniprot_entry
EPHX3_HUMAN
resolver
uniprot_sec
A3KMR3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 1-(1-acetylpiperidin-4-yl)-3-(4-(trifl uoromethoxy)phenyl)urea (TPAU), 1-cyclohexyl-3-dodecylurea (CDU), 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA), 1-((3S, 5S, 7S)-adamantan-1-yl)-3-(5-(2-(2-ethoxyethoxy) ethoxy)pentyl)urea (AEPU) and to a lesser extent by 8-(3-((3S, 5S, 7S)-adamantan-1-yl)ureido) octanoic acid (AUOA). {ECO:0000269|PubMed:22798687}.
uniprot
proteins
amino_acid_sequence
MPELVVTALLAPSRLSLKLLRAFMWSLVFSVALVAAAVYGCIALTHVLCRPRRGCCGRRRSASPACLSDPSLGEHGFLNLKSSGLRLHYVSAGRGNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVDCYTIDLLLVDIKDVILGLGYSKCILVAHDWGALLAWHFSIYYPSLVERMVVVSGAPMSVYQDYSLHHISQFFRSHYMFLFQLPWLPEKLLSMSDFQILKTTLTHRKTGIPCLTPSELEAFLYNFSQPGGLTGPLNYYRNLFRNFPLEPQELTTPTLLLWGEKDTYLELGLVEAIGSRFVPGRLEAHILPGIGHWIPQSNPQEMHQYMWAFLQDLLD
uniprot
proteins
ec_number
3.3.2.10
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9-EET, 9,10-EET, 11,12-EET and 14,15-EET and leukotoxin. {ECO:0000269|PubMed:22798687}.
uniprot
proteins
mass_dalton
40909
uniprot
proteins
mutagenesis
MUTAGEN 173; /note="D->A: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:22798687"; MUTAGEN 173; /note="D->N: No effect on catalytic activity."; /evidence="ECO:0000269|PubMed:22798687"; MUTAGEN 220; /note="Y->F: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:22798687"; MUTAGEN 280; /note="Y->F: No effect on catalytic activity."; /evidence="ECO:0000269|PubMed:22798687"; MUTAGEN 281; /note="Y->F: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:22798687"; MUTAGEN 307; /note="D->A,N: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:22798687"; MUTAGEN 337; /note="H->Q: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:22798687
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
Epoxide hydrolase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22798687
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305|PubMed:22798687}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins