Cds2
entrez
110911
canonical
uniprot
Q99L43
canonical
ensembl
ENSMUSG00000058793
resolver
ensp
ENSMUSP00000086886
resolver
ensp
ENSMUSP00000099470
resolver
ensp
ENSMUSP00000105786
resolver
enst
ENSMUST00000089461
resolver
enst
ENSMUST00000103181
resolver
enst
ENSMUST00000110158
resolver
genesymbol
Cds2
resolver
uniprot
A2AMQ5
resolver
uniprot
F6YN89
resolver
uniprot
Q3TMD1
resolver
uniprot
Q6NSU1
resolver
uniprot
Q6PBC0
resolver
uniprot
Q8BX08
resolver
uniprot_entry
A2AMQ5_MOUSE
resolver
uniprot_entry
CDS2_MOUSE
resolver
uniprot_entry
F6YN89_MOUSE
resolver
uniprot_entry
Q6PBC0_MOUSE
resolver
uniprot_entry
Q8BX08_MOUSE
resolver
uniprot_sec
Q3TMD1
resolver
uniprot_sec
Q6NSU1
resolver
amino_acid_sequence
MTELRQRVVREDAPPEDKESESEAKLDGETASDSESRAETAPLPTSVDDTPEVLNRALSNLSSRWKNWWVRGILTLAMIAFFFIIIYLGPMVLMMIVMCVQIKCFHEIITIGYNVYHSYDLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRILSKYHRFISFALYLTGFCMFVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLVIHNLFEGMIWFIVPISCVICNDIMAYMFGFFFGRTPLIKLSPKKTWEGFIGGFFATVVFGLLLSYVMSGYRCFVCPVEYNNDTNSFTVDCEPSDLFRLQEYNIPGVIQSAIGWKTVRMYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVNVYIASFIRGPNPSKLIQQFLTLRPDQQLHIFNTLKSHLTDKGILTSALEDE
uniprot
proteins
ec_number
2.7.7.41
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (By similarity). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (By similarity). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540). {ECO:0000250|UniProtKB:O95674, ECO:0000269|PubMed:26946540}.
uniprot
proteins
mass_dalton
51314
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
uniprot
proteins
protein_family
CDS family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16023307
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17208939
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26946540
uniprot
proteins
sequence_length
444
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16023307}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 78..98; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 129..149; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 212..232; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 261..281; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 339..359; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins