Cd33
entrez
12489
canonical
uniprot
Q63994
canonical
ensembl
ENSMUSG00000004609
resolver
ensp
ENSMUSP00000004728
resolver
ensp
ENSMUSP00000146225
resolver
genesymbol
Cd33
resolver
genesymbol_syn
Siglec3
resolver
uniprot
A2RT59
resolver
uniprot
Q63997
resolver
uniprot_entry
CD33_MOUSE
resolver
uniprot_sec
A2RT59
resolver
uniprot_sec
Q63997
resolver
amino_acid_sequence
MLWPLPLFLLCAGSLAQDLEFQLVAPESVTVEEGLCVHVPCSVFYPSIKLTLGPVTGSWLRKGVSLHEDSPVATSDPRQLVQKATQGRFQLLGDPQKHDCSLFIRDAQKNDTGMYFFRVVREPFVRYSYKKSQLSLHVTSLSRTPDIIIPGTLEAGYPSNLTCSVPWACEQGTPPTFSWMSTALTSLSSRTTDSSVLTFTPQPQDHGTKLTCLVTFSGAGVTVERTIQLNVTRKSGQMRELVLVAVGEATVKLLILGLCLVFLIVMFCRRKTTKLSVHMGCENPIKRQEAITSYNHCLSPTASDAVTPGCSIHRLISRTPRCTAILRIQDPYRRTHLRNRAVSTLRFPWISWEGSLRSTQRSKCTKLCSPVKNLCPLWLPVDNSCIPLIPEWVMLLCVSLTLS
uniprot
proteins
function
FUNCTION: Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (By similarity). Preferentially binds sialic acid to the short O-linked glycans of certain mucins (PubMed:12773563). {ECO:0000250|UniProtKB:P20138, ECO:0000269|PubMed:12773563}.
uniprot
proteins
mass_dalton
44824
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:P20138}.; PTM: Phosphorylation is involved in binding to PTPN6 and PTPN11. {ECO:0000250|UniProtKB:P20138}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
SIGLEC (sialic acid binding Ig-like lectin) family
uniprot
proteins
pubmed
12773563
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8193354
uniprot
proteins
sequence_length
403
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20138}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P20138}.
uniprot
proteins
transmembrane_region
TRANSMEM 241..267; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins