ANKRD28
entrez
23243
canonical
uniprot
O15084
canonical
ensembl
ENSG00000206560
resolver
ensp
ENSP00000382379
resolver
ensp
ENSP00000485421
resolver
ensp
ENSP00000508086
resolver
ensp
ENSP00000675900
resolver
genesymbol
ANKRD28
resolver
genesymbol_syn
KIAA0379
resolver
hgnc
HGNC:29024
resolver
uniprot
B4DES5
resolver
uniprot
Q1WWL4
resolver
uniprot
Q29RW6
resolver
uniprot
Q3B857
resolver
uniprot
Q6ULS0
resolver
uniprot
Q6ZT57
resolver
uniprot_entry
ANR28_HUMAN
resolver
uniprot_sec
B4DES5
resolver
uniprot_sec
Q1WWL4
resolver
uniprot_sec
Q29RW6
resolver
uniprot_sec
Q3B857
resolver
uniprot_sec
Q6ULS0
resolver
uniprot_sec
Q6ZT57
resolver
amino_acid_sequence
MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRNEPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY
uniprot
proteins
function
FUNCTION: Regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. Involved in the PP6-mediated dephosphorylation of MOB1 and induced focal adhesion assembly during cell migration (PubMed:35512830). {ECO:0000269|PubMed:16564677, ECO:0000269|PubMed:18186651, ECO:0000269|PubMed:35512830}.
uniprot
proteins
mass_dalton
112966
uniprot
proteins
mutagenesis
MUTAGEN 1007..1011; /note="SKTVS->AKTVA: Marked decrease in phosphorylation. Increased PPP1C-binding. No effect on HNRPK-binding."; /evidence="ECO:0000269|PubMed:16564677
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the ECS(RAB40C) complex leading to its degradation and decreased PP6 activity. {ECO:0000269|PubMed:35512830}.
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16564677
uniprot
proteins
pubmed
18186651
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
35512830
uniprot
proteins
pubmed
9205841
uniprot
proteins
sequence_length
1053
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:16564677}. Cytoplasm, cytosol {ECO:0000269|PubMed:35512830}. Cell projection, lamellipodium {ECO:0000269|PubMed:35512830}. Note=Seems to be excluded from nucleoli. Mostly localized in the cytosol, but a fraction could be observed at the lamellipodia (PubMed:35512830). {ECO:0000269|PubMed:35512830}.
uniprot
proteins