Adgrl3
entrez
170641
canonical
uniprot
Q9Z173
canonical
ensembl
ENSRNOG00000030149
resolver
ensembl
ENSRNOG00055016072
resolver
ensembl
ENSRNOG00060012994
resolver
ensembl
ENSRNOG00065005299
resolver
ensp
ENSRNOP00000045365
resolver
ensp
ENSRNOP00000056687
resolver
ensp
ENSRNOP00000083229
resolver
ensp
ENSRNOP00000099227
resolver
enst
ENSRNOT00000044659
resolver
enst
ENSRNOT00000131643
resolver
genesymbol
Adgrl3
resolver
genesymbol_syn
Cirl3
resolver
genesymbol_syn
Cl3
resolver
genesymbol_syn
Lphn3
resolver
uniprot
A0ABK0L4J0
resolver
uniprot
D4AAL4
resolver
uniprot
O88924
resolver
uniprot
O88925
resolver
uniprot
O88926
resolver
uniprot
O88927
resolver
uniprot
O88928
resolver
uniprot
O88929
resolver
uniprot
Q4LDM4
resolver
uniprot
Q4LDM5
resolver
uniprot
Q4LDM6
resolver
uniprot
Q4LDM7
resolver
uniprot
Q4LDM8
resolver
uniprot_entry
A0ABK0L4J0_RAT
resolver
uniprot_entry
AGRL3_RAT
resolver
uniprot_entry
D4AAL4_RAT
resolver
uniprot_sec
O88924
resolver
uniprot_sec
O88925
resolver
uniprot_sec
O88926
resolver
uniprot_sec
O88927
resolver
uniprot_sec
O88928
resolver
uniprot_sec
O88929
resolver
uniprot_sec
Q4LDM4
resolver
uniprot_sec
Q4LDM5
resolver
uniprot_sec
Q4LDM6
resolver
uniprot_sec
Q4LDM7
resolver
uniprot_sec
Q4LDM8
resolver
activity_regulation
ACTIVITY REGULATION: Forms a heterodimer of 2 chains generated by proteolytic processing that remain associated through non-covalent interactions mediated by the GAIN-B domain (By similarity). In the inactivated receptor, the Stachel sequence (also named stalk) is embedded in the GAIN-B domain, where it adopts a beta-strand conformation. On activation, the Stachel moves into the 7 transmembrane region and adopts a twisted hook-shaped configuration that forms contacts within the receptor, leading to coupling of a G-alpha protein, which activates signaling. The cleaved GAIN-B and N-terminal domains can then dissociate from the rest of the receptor (By similarity). {ECO:0000250|UniProtKB:Q80TS3, ECO:0000250|UniProtKB:Q9HAR2}.
uniprot
proteins
amino_acid_sequence
MCPPQLFILMMLLAPVVHGGKHNERHPALAAPLRHAEHSPGGPLPPRHLLQQPAAERSTAHRGQGPRGTARGVRGPGAPGAQIAAQAFSRAPIPMAVVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLTEYSSKDDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIEGTWDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNSYQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRSGPVHHGQVSYISPPIHLDSDLERPPVRGISTTGPLGMGSTTTSTTLRTTTWNLGRSTTPSLPGRRNRSTSTPSPAIEVLDVTTHLPSAASQIPAMEESCEAVEAREIMWFKTRQGQVAKQSCPAGTIGVSTYLCLAPDGIWDPQGPDLSNCSSPWVNHITQKLKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVGLLDVQLRNLTPGGKDSAARSLNKLQKRERSCRAYVQAMVETVNNLLQPQALNAWRDLTTSDQLRAATMLLDTVEESAFVLADNLLKTDIVRENTDNIQLEVARLSTEGNLEDLKFPENTGHGSTIQLSANTLKQNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTEAMSTNHSVIVNSPVITAAINKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYWSTQGCRLLTTNKTHTTCSCNHLTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNINYEDNRPFIKSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGKCLRTHCCSGKSTESSIGSGKTSGSRTPGRYSTGSQSRIRRMWNDTVRKQSESSFITGDINSSASLNRGSYLPCIQACVTYLEGLLNNARDTSVMDTLPLNGNHGNSYSIAGGEYLSNCVQIIDRGYNHNETALEKKILKELTSNYIPSYLNNHERSSEQNRNMMNKLVDNLGSGSEDDAIVLDDAASFNHEESLGLELIHEESDAPLLPPRVYSTDNHQPHHYSRRRLPQDHSESFFPLLTDEHTEDPQSPHRDSLYTSMPALAGVPAADSVTTSTQTEAAAAKGGDAEDVYYKSMPNLGSRNHVHPLHAYYQLGRGSSDGFIVPPNKDGASPEGTSKGPAHLVTSL
uniprot
proteins
function
FUNCTION: Orphan adhesion G protein-coupled receptor (aGPCR), which mediates synapse specificity. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. ADGRL3 is coupled with different classes of G alpha proteins, such as G(12)/G(13), G(s), G(i) or G(q), depending on the context. Coupling to G(12)/G(13) G proteins, which mediates the activation Rho small GTPases is the most efficient. Following G protein-coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of Schaffer-collateral synapses formed by CA3-region axons on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.oriens and S.radiatum and interacts with presynaptic cell adhesion molecules FLRT3 and TENM2, promoting synapse formation. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. {ECO:0000250|UniProtKB:Q80TS3}.; FUNCTION: [Isoform 1]: Orphan adhesion G protein-coupled receptor (aGPCR), which mediates synapse specificity. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. Isoform 1 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Following G protein-coupled receptor activation, undergoes liquid-liquid phase transition, associates with (1) cell adhesion molecules that are expressed at the surface of adjacent cells, as well as (2) PDZ-containing proteins, such as SHANK3 and DLG4, in the cytoplasm to direct synapse formation. {ECO:0000250|UniProtKB:Q80TS3}.
uniprot
proteins
mass_dalton
172442
uniprot
proteins
post_translational_modification
PTM: Autoproteolytically processed at the GPS region of the GAIN-B domain; this cleavage modulates receptor activity. {ECO:0000250|UniProtKB:Q80TS3, ECO:0000255|PROSITE-ProRule:PRU00098}.
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
protein_family
LN-TM7 subfamily
uniprot
proteins
pubmed
10026162
uniprot
proteins
pubmed
22405201
uniprot
proteins
pubmed
9830014
uniprot
proteins
sequence_length
1550
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q80TS3}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q80TS3}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:Q80TS3}. Cell junction {ECO:0000250|UniProtKB:Q80TS3}.
uniprot
proteins
transmembrane_region
TRANSMEM 949..969; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 978..998; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 1007..1027; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 1049..1069; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 1088..1108; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 1142..1162; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 1169..1189; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins