BMP7
entrez
655
canonical
uniprot
P18075
canonical
ensembl
ENSG00000101144
resolver
ensp
ENSP00000379204
resolver
enst
ENST00000395863
resolver
genesymbol
BMP7
resolver
genesymbol_syn
OP1
resolver
hgnc
HGNC:1074
resolver
uniprot
A8K571
resolver
uniprot
Q9H512
resolver
uniprot
Q9NTQ7
resolver
uniprot_entry
A8K571_HUMAN
resolver
uniprot_entry
BMP7_HUMAN
resolver
uniprot_sec
Q9H512
resolver
uniprot_sec
Q9NTQ7
resolver
amino_acid_sequence
MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH
uniprot
proteins
function
FUNCTION: Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:31208997). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A (PubMed:12667445, PubMed:9748228). Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:12478285). For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, also uses BMPR2 as type II receptor (PubMed:31208997). Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509). {ECO:0000269|PubMed:12478285, ECO:0000269|PubMed:12667445, ECO:0000269|PubMed:27923061, ECO:0000269|PubMed:30097509, ECO:0000269|PubMed:31208997, ECO:0000269|PubMed:9748228}.
uniprot
proteins
mass_dalton
49313
uniprot
proteins
post_translational_modification
PTM: Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms. {ECO:0000269|PubMed:17977014}.
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12478285
uniprot
proteins
pubmed
12667445
uniprot
proteins
pubmed
15020244
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17977014
uniprot
proteins
pubmed
18184661
uniprot
proteins
pubmed
18339631
uniprot
proteins
pubmed
20506283
uniprot
proteins
pubmed
2263636
uniprot
proteins
pubmed
2357959
uniprot
proteins
pubmed
27923061
uniprot
proteins
pubmed
30097509
uniprot
proteins
pubmed
31208997
uniprot
proteins
pubmed
33308444
uniprot
proteins
pubmed
8570652
uniprot
proteins
pubmed
9748228
uniprot
proteins
sequence_length
431
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins