Taar5
entrez
215854
canonical
uniprot
Q5QD14
canonical
ensembl
ENSMUSG00000069706
resolver
ensp
ENSMUSP00000090329
resolver
enst
ENSMUST00000092659
resolver
genesymbol
Taar5
resolver
genesymbol_syn
Gm227
resolver
uniprot
B2RTA0
resolver
uniprot_entry
B2RTA0_MOUSE
resolver
uniprot_entry
TAAR5_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 1-[(5,5- diphenyloxolan-2-yl)methyl]-4-(2-methoxyphenyl)piperazine and N-[(2,2-diphenyl-1,3-dioxolan-4-yl)methyl]-2-(2- methoxyphenoxy)ethan-1-amine small molecules. {ECO:0000269|PubMed:37847527}.
uniprot
proteins
amino_acid_sequence
MRAVLLPGSGEQPTAFCYQVNGSCPRTVHPLAIQVVIYLACAVGVLITVLGNLFVVFAVSYFKVLHTPTNFLLLSLALADMLLGLLVLPLSTVRSVESCWFFGDFLCRLHTYLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTVRTALRYIVAGWGIPAAYTAFFLYTDVVERALSQWLEEMPCVGSCQLLFNKFWGWLNFPAFFVPCLIMISLYLKIFVVATRQAQQIRTLSQSLAGAVKRERKAAKTLGIAVGIYLVCWLPFTVDTLVDSLLNFITPPLVFDIFIWFAYFNSACNPIIYVFSYRWFRKALKLLLSREIFSPRTPTVDLYHD
uniprot
proteins
function
FUNCTION: Olfactory receptor specific for trimethylamine, a trace amine enriched in the urine of male mice, playing a role in social behavior (PubMed:16878137, PubMed:22545963, PubMed:23177478, PubMed:27208093, PubMed:30038239, PubMed:37225986, PubMed:37847527). Also activated by N-methylpiperidine (PubMed:22545963). Trimethylamine is present at high concentration in the urine of male mice after puberty and acts as an attractant (PubMed:16878137, PubMed:23177478, PubMed:37225986). Trimethylamine-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (PubMed:37225986). Also required to provide olfactory input into limbic brain areas to regulate emotional behaviors likely via modulation of the serotonin system (PubMed:32194374, PubMed:33132188, PubMed:36038766). {ECO:0000269|PubMed:16878137, ECO:0000269|PubMed:22545963, ECO:0000269|PubMed:23177478, ECO:0000269|PubMed:27208093, ECO:0000269|PubMed:30038239, ECO:0000269|PubMed:32194374, ECO:0000269|PubMed:33132188, ECO:0000269|PubMed:36038766, ECO:0000269|PubMed:37225986, ECO:0000269|PubMed:37847527}.
uniprot
proteins
mass_dalton
38220
uniprot
proteins
mutagenesis
MUTAGEN 17; /note="C->S: Does not affect trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 24; /note="C->S: Decreased trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 99; /note="C->S: Does not affect trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 111; /note="T->A: Abolished signaling via the G(s)-class of G-proteins."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 114; /note="D->A: Abolished trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 115; /note="T->A,I,Y,L: Abolished signaling via the G(s)-class of G proteins."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 118; /note="C->A: Does not affect trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 188; /note="C->S: Decreased trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 257; /note="A->I,L: Decreased activation of GNAL/G(olf) G alpha protein in response to trace amine-binding without affecting activation of G(s) G alpha proteins."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 265; /note="W->A: Abolished trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 295; /note="Y->A: Abolished trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15718104
uniprot
proteins
pubmed
16878137
uniprot
proteins
pubmed
22545963
uniprot
proteins
pubmed
22837392
uniprot
proteins
pubmed
23177478
uniprot
proteins
pubmed
23624375
uniprot
proteins
pubmed
27208093
uniprot
proteins
pubmed
30038239
uniprot
proteins
pubmed
32194374
uniprot
proteins
pubmed
33132188
uniprot
proteins
pubmed
34845253
uniprot
proteins
pubmed
36038766
uniprot
proteins
pubmed
37225986
uniprot
proteins
pubmed
37847527
uniprot
proteins
sequence_length
337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O14804}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14804}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 205..225; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 254..274; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 285..307; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins