SRXN1
entrez
140809
canonical
uniprot
Q9BYN0
canonical
ensembl
ENSG00000271303
resolver
ensp
ENSP00000371388
resolver
enst
ENST00000381962
resolver
genesymbol
SRXN1
resolver
genesymbol_syn
C20orf139
resolver
genesymbol_syn
SRX
resolver
genesymbol_syn
SRX1
resolver
hgnc
HGNC:16132
resolver
uniprot
B2R543
resolver
uniprot
Q8NDM3
resolver
uniprot
Q96AK6
resolver
uniprot_entry
SRXN1_HUMAN
resolver
uniprot_sec
B2R543
resolver
uniprot_sec
Q8NDM3
resolver
uniprot_sec
Q96AK6
resolver
amino_acid_sequence
MGLRAGGTLGRAGAGRGAPEGPGPSGGAQGGSIHSGRIAAVHNVPLSVLIRPLPSVLDPAKVQSLVDTIREDPDSVPPIDVLWIKGAQGGDYFYSFGGCHRYAAYQQLQRETIPAKLVQSTLSDLRVYLGASTPDLQ
uniprot
proteins
ec_number
1.8.98.2
uniprot
proteins
function
FUNCTION: Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4 (PubMed:15448164, PubMed:15590625). Does not act on PRDX5 or PRDX6 (PubMed:15448164, PubMed:15590625). May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase (PubMed:15448164, PubMed:15590625). {ECO:0000269|PubMed:15448164, ECO:0000269|PubMed:15590625}.
uniprot
proteins
mass_dalton
14259
uniprot
proteins
mutagenesis
MUTAGEN 99; /note="C->S: No effect on association with PRDX1, PRDX2, PRDX3 or PRDX4."; /evidence="ECO:0000269|PubMed:15590625
uniprot
proteins
protein_family
Sulfiredoxin family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15448164
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15590625
uniprot
proteins
pubmed
15952770
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
137
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15448164}.
uniprot
proteins