Map3k13
entrez
71751
canonical
uniprot
Q1HKZ5
canonical
ensembl
ENSMUSG00000033618
resolver
ensp
ENSMUSP00000047388
resolver
ensp
ENSMUSP00000156075
resolver
ensp
ENSMUSP00000156202
resolver
enst
ENSMUST00000042065
resolver
enst
ENSMUST00000231988
resolver
enst
ENSMUST00000232240
resolver
genesymbol
Map3k13
resolver
uniprot
Q8BKN0
resolver
uniprot_entry
M3K13_MOUSE
resolver
uniprot_sec
Q8BKN0
resolver
activity_regulation
ACTIVITY REGULATION: Activated by autophosphorylation and homodimerization. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MANPQEHLSCSSLPHLPLTENKTSGGRNELAAMGNHPSPKLPEDPQERGAIQSELMEITGSPISTTVLTSVSEDSRGQFENSVLQLREQDESEMTLSLGNSNTVDGENTNGPEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELLKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKAGVQTKRPDLLRSEGIPSTEAVPTASPLSGSPKMSTASSRSRYRSKPRHRRGNSRGSHSDFAAILKTQPAQENSPHPTYMHHTQAQCASVHQHNPLQQQYQQIPPAQPQSRHPRLNAHGQDIATCANNLRYFGPAAALRSPLSNHAQRQMPGSSPDLISTAMAADWRNSELDQDQVGPWGCCQAEPYDPCFQCRPEHSGSLDVPTTEPVGRSPDLSSSPAHNPLSGNAQGSERTGANGFSGCQSGISHQFTPPMLPQKTRPLQKSGDDSSEEEGEVDSEVEFPRRQRPHRCISSYQSYSTFSSENFSVSDGEEGNTSDHSNSPDESANRRQDRLAETLDDLLSQTPEAPIEISSHSDGLSDKECAVRRVKTQMSLGKLCAEERGYENPVQFGDSDCDSSEGECSDATVRTSKNYSSATW
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
106987
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on serine and threonine residues. {ECO:0000250}.
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
959
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
uniprot
proteins