CCN4
entrez
8840
canonical
uniprot
O95388
canonical
ensembl
ENSG00000104415
resolver
ensp
ENSP00000220856
resolver
ensp
ENSP00000250160
resolver
ensp
ENSP00000427744
resolver
ensp
ENSP00000429185
resolver
genesymbol
CCN4
resolver
genesymbol_syn
WISP1
resolver
hgnc
HGNC:12769
resolver
uniprot
A8KAG6
resolver
uniprot
E7EMM5
resolver
uniprot
Q5JBS6
resolver
uniprot
Q5JBS7
resolver
uniprot
Q5JBS8
resolver
uniprot
Q9HCS3
resolver
uniprot_entry
CCN4_HUMAN
resolver
uniprot_sec
A8KAG6
resolver
uniprot_sec
E7EMM5
resolver
uniprot_sec
Q5JBS6
resolver
uniprot_sec
Q5JBS7
resolver
uniprot_sec
Q5JBS8
resolver
uniprot_sec
Q9HCS3
resolver
amino_acid_sequence
MRWFLPWTLAAVTAAAASTVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYPDFSEIAN
uniprot
proteins
function
FUNCTION: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. {ECO:0000269|PubMed:10716946, ECO:0000269|PubMed:11782444}.
uniprot
proteins
mass_dalton
40331
uniprot
proteins
protein_family
CCN family
uniprot
proteins
pubmed
10716946
uniprot
proteins
pubmed
11571650
uniprot
proteins
pubmed
11598131
uniprot
proteins
pubmed
11782444
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
9843955
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins