Eci2
entrez
23986
canonical
uniprot
Q9WUR2
canonical
ensembl
ENSMUSG00000021417
resolver
ensp
ENSMUSP00000021854
resolver
ensp
ENSMUSP00000131735
resolver
ensp
ENSMUSP00000137411
resolver
genesymbol
Eci2
resolver
genesymbol_syn
Peci
resolver
uniprot
Q99M61
resolver
uniprot
Q9D785
resolver
uniprot_entry
ECI2_MOUSE
resolver
uniprot_sec
Q99M61
resolver
uniprot_sec
Q9D785
resolver
amino_acid_sequence
MAAVTWSRARCWCPSVLQVFRLQVAKLHLGRPTMRASQQDFENALNQVKLLKKDPGNEVKLRLYALYKQATEGPCNMPKPGMLDFVNKAKWDAWNALGSLPKETARQNYVDLVSSLSSSSEAPSQGKRGADEKARESKDILVTSEDGITKITFNRPTKKNAISFQMYRDIILALKNASTDNTVMAVFTGTGDYYCSGNDLTNFTSATGGIEEAASNGAVLLRDFVNSFIDFPKPLVAVVNGPAVGISVTLLGLFDAVFASDRATFHTPFSQLGQSPEACSSYTFPKMMGSAKAAEMLLFGKKLTAREAWAQGLVTEVFPESTFETEVWTRLKTYAKLPPNAMRISKELIRKNEKEKLYAVNAEECTTLQARWLSEECMNAIMSFVSRKPKL
uniprot
proteins
ec_number
5.3.3.8
uniprot
proteins
function
FUNCTION: Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids. Together with the 2,4-dienoyl-CoA reductase (DECR) and the Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (ECH), they allow the reentrance of the enoyl-CoA into the beta-oxidation cycle (PubMed:24344334). Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of fatty enoyl-CoA species, with a preference for (3E)-enoyl-CoAs over (3Z)-enoyl-CoAs (PubMed:24344334). Based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally (Probable). {ECO:0000269|PubMed:24344334, ECO:0000305|PubMed:24344334}.
uniprot
proteins
mass_dalton
43268
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000269|PubMed:24344334}.
uniprot
proteins
post_translational_modification
PTM: Acetylation of Lys-60 is observed in liver mitochondria from fasted mice but not from fed mice.
uniprot
proteins
protein_family
Enoyl-CoA hydratase/isomerase family
uniprot
proteins
pubmed
10419495
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24344334
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:24344334}.; SUBCELLULAR LOCATION: [Isoform 2]: Peroxisome matrix {ECO:0000269|PubMed:24344334}.
uniprot
proteins