Trim6
entrez
94088
canonical
uniprot
Q8BGE7
canonical
ensembl
ENSMUSG00000072244
resolver
ensp
ENSMUSP00000095782
resolver
ensp
ENSMUSP00000337297
resolver
ensp
ENSMUSP00000337300
resolver
enst
ENSMUST00000098180
resolver
genesymbol
Trim6
resolver
uniprot
B2RSQ8
resolver
uniprot
Q99PQ6
resolver
uniprot_entry
TRIM6_MOUSE
resolver
uniprot_sec
B2RSQ8
resolver
uniprot_sec
Q99PQ6
resolver
amino_acid_sequence
MTSTVLVDIRDEVTCPICLELLTEPLSIDCGHSFCQVCIIGNSNNSVFGQGGRSSCPVCRTSYQPGNLRPNRHLAAIVKRLREVALCPGKQLEVIFCALHGEKLQLFCKEDGKLICWLCERSQEHRGHHTFLMEEVAQEYQDMFQESLKKLRREQQEAEKLKALIQEKRESWKSQVEPEKRRIQTEFKQLRSILDREEQRELKKLEVEERKGLSIIEKAEGDLIHQSQSLKDLISDLEHRCQGSTVELLQDVGDVTKRSEFWTLRKPQALPTKLKSLFRAPDLRKMLKVFRELTDVQSYWVDVTLNPQTANLNLVLSKNRRQVRFVGAQLSEPSSLEEHYDCSVLGSQHFSSGKYYWEVDVSKKTAWILGVCSTPVDPMFSFSQYSSKQGAYSRYQPQCGYWVIGLQCKHEYRAYEDSSPSLLLSMTVPPRRIGIFLDCEAGTVSFYNVTNHGLPIYTFSKYYFPSALCPYFNPCSCIVPMTLRRPTS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway (PubMed:24882218). In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response (PubMed:24882218). Also ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (PubMed:22328504). Promotes the association of unanchored 'Lys-48'-polyubiquitin chains with DHX16 leading to enhancement of RIGI-mediated innate antiviral immune response (By similarity). {ECO:0000250|UniProtKB:Q9C030, ECO:0000269|PubMed:22328504, ECO:0000269|PubMed:24882218}.
uniprot
proteins
mass_dalton
56152
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:22328504}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22328504
uniprot
proteins
pubmed
24882218
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22328504}.
uniprot
proteins