Kif2a
entrez
16563
canonical
uniprot
P28740
canonical
ensembl
ENSMUSG00000021693
resolver
ensp
ENSMUSP00000022204
resolver
ensp
ENSMUSP00000112715
resolver
ensp
ENSMUSP00000113361
resolver
ensp
ENSMUSP00000113921
resolver
ensp
ENSMUSP00000125644
resolver
ensp
ENSMUSP00000257812
resolver
ensp
ENSMUSP00000257813
resolver
enst
ENSMUST00000159772
resolver
genesymbol
Kif2a
resolver
genesymbol_syn
Kif2
resolver
genesymbol_syn
Kns2
resolver
uniprot
E0CZ72
resolver
uniprot
O54744
resolver
uniprot
Q91W03
resolver
uniprot
Q9D481
resolver
uniprot_entry
E0CZ72_MOUSE
resolver
uniprot_entry
KIF2A_MOUSE
resolver
uniprot_entry
Q9D481_MOUSE
resolver
uniprot_sec
O54744
resolver
uniprot_sec
Q91W03
resolver
amino_acid_sequence
MATANFGKIQIGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWIENGDTKGKEIDLESIFSLNPDLVPDEDIEPSPELPPPSSSSKVNKIVKNRRTVAAVKNDPPPRDNRVVGSARARPSQLPEQSSSAQQNGSVSDISPVQAAKKEFGPPSRRKSNCVKEVEKLQEKREKRRLQQQELREKRAQDVDATNPNYEIMCMIRDFRGSLDYRPLTTADPIDEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKTKLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRKGKLHGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRVKELTVNPAAAGDVHPIMHHPPSQIDDLETQWGVGSSPQRDDLKLLCEQNEEEVSPQLFTFHEAVSQMVEMEEQVVEDHRAVFQESIRWIEDEKALLEMTEEVDYDVDSYATQLEAILEQKIDILTELRDKVKSFRAALQEEEQASKQINPKRPRAL
uniprot
proteins
function
FUNCTION: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity). {ECO:0000250|UniProtKB:O00139, ECO:0000269|PubMed:12887924, ECO:0000269|PubMed:9774330}.
uniprot
proteins
mass_dalton
79756
uniprot
proteins
protein_family
Kinesin family
uniprot
proteins
protein_family
MCAK/KIF2 subfamily
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
12887924
uniprot
proteins
pubmed
1447303
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24339785
uniprot
proteins
pubmed
9774330
uniprot
proteins
sequence_length
705
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9774330}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:9774330}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:9774330}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Lysosome {ECO:0000269|PubMed:9774330}. Note=Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1 (By similarity). Associated with lysosomes in NIH3T3 cells. {ECO:0000250}.
uniprot
proteins