Pcsk2
entrez
18549
canonical
uniprot
P21661
canonical
ensembl
ENSMUSG00000027419
resolver
ensp
ENSMUSP00000028905
resolver
enst
ENSMUST00000028905
resolver
genesymbol
Pcsk2
resolver
genesymbol_syn
Nec-2
resolver
genesymbol_syn
Nec2
resolver
uniprot
Q547J8
resolver
uniprot
Q80WU1
resolver
uniprot_entry
NEC2_MOUSE
resolver
uniprot_entry
Q547J8_MOUSE
resolver
uniprot_sec
Q80WU1
resolver
amino_acid_sequence
MEGGCGSQWKAAGFLFCVMVFASAERPVFTNHFLVELHKDGEEEARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKRQLERDPRIKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLFNTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAYNYNADASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAASNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLDLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQNPEKIPPTGKLVLTLKTNACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGLLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKQELEEELDEAVERSLQSILRKN
uniprot
proteins
ec_number
3.4.21.94
uniprot
proteins
function
FUNCTION: Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (PubMed:17467653). Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). Mediates the release of insulin from proinsulin (By similarity). {ECO:0000250|UniProtKB:P16519, ECO:0000269|PubMed:17467653}.
uniprot
proteins
mass_dalton
70785
uniprot
proteins
protein_family
Furin subfamily
uniprot
proteins
protein_family
Peptidase S8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17467653
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2169760
uniprot
proteins
pubmed
2264933
uniprot
proteins
sequence_length
637
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P16519}. Secreted {ECO:0000250|UniProtKB:P16519}. Note=Localized in the secretion granules. {ECO:0000250|UniProtKB:P16519}.
uniprot
proteins