PDIA3
entrez
2923
canonical
uniprot
P30101
canonical
ensembl
ENSG00000167004
resolver
ensp
ENSP00000300289
resolver
enst
ENST00000300289
resolver
genesymbol
HEL-S-269
resolver
genesymbol
PDIA3
resolver
genesymbol_syn
ERP57
resolver
genesymbol_syn
ERP60
resolver
genesymbol_syn
GRP58
resolver
genesymbol_syn
HEL-S-93n
resolver
genesymbol_syn
PDIA3
resolver
hgnc
HGNC:4606
resolver
uniprot
Q13453
resolver
uniprot
Q14255
resolver
uniprot
Q8IYF8
resolver
uniprot
Q9UMU7
resolver
uniprot
V9HVY3
resolver
uniprot_entry
PDIA3_HUMAN
resolver
uniprot_entry
V9HVY3_HUMAN
resolver
uniprot_sec
Q13453
resolver
uniprot_sec
Q14255
resolver
uniprot_sec
Q8IYF8
resolver
uniprot_sec
Q9UMU7
resolver
activity_regulation
ACTIVITY REGULATION: Association with calcitriol does not affect its enzymatic activity. {ECO:0000269|PubMed:27897272}.
uniprot
proteins
amino_acid_sequence
MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREATNPPVIQEEKPKKKKKAQEDL
uniprot
proteins
ec_number
5.3.4.1
uniprot
proteins
function
FUNCTION: Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}.
uniprot
proteins
mass_dalton
56782
uniprot
proteins
mutagenesis
MUTAGEN 57; /note="C->A: No loss of activity. No loss of activity; when associated with A-406."; /evidence="ECO:0000269|PubMed:9399589"; MUTAGEN 57; /note="C->S: Activity changed to serine protease."; /evidence="ECO:0000269|PubMed:9399589"; MUTAGEN 60; /note="C->A: Trapped via disulfide bond with TAPBP."; /evidence="ECO:0000269|PubMed:11825568"; MUTAGEN 60; /note="C->S: Activity changed to serine protease; when associated with S-409."; /evidence="ECO:0000269|PubMed:9399589"; MUTAGEN 406; /note="C->A: No loss of activity. No loss of activity; when associated with A-57."; /evidence="ECO:0000269|PubMed:9399589"; MUTAGEN 406; /note="C->S: Activity changed to serine protease."; /evidence="ECO:0000269|PubMed:9399589"; MUTAGEN 409; /note="C->A: No effect on disulfide bond with TAPBP."; /evidence="ECO:0000269|PubMed:11825568"; MUTAGEN 409; /note="C->S: Activity changed to serine protease; when associated with S-60."; /evidence="ECO:0000269|PubMed:9399589
uniprot
proteins
post_translational_modification
PTM: Within the major histocompatibility complex class I (MHC I) peptide loading complex forms reversible disulfide-linked heterodimers with TAPBP as part of its protein folding chaperone activity. This is essential to assist the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. {ECO:0000269|PubMed:11825568}.; PTM: Phosphorylated. {ECO:0000250|UniProtKB:P27773}.
uniprot
proteins
protein_family
Protein disulfide isomerase family
uniprot
proteins
pubmed
11825568
uniprot
proteins
pubmed
11840567
uniprot
proteins
pubmed
12643545
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
1286669
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16193070
uniprot
proteins
pubmed
16258833
uniprot
proteins
pubmed
16905107
uniprot
proteins
pubmed
16940051
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
19119025
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20400973
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
23826168
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24188822
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27897272
uniprot
proteins
pubmed
35948544
uniprot
proteins
pubmed
36104323
uniprot
proteins
pubmed
7487104
uniprot
proteins
pubmed
7945384
uniprot
proteins
pubmed
8624847
uniprot
proteins
pubmed
8687406
uniprot
proteins
pubmed
9150946
uniprot
proteins
pubmed
9150948
uniprot
proteins
pubmed
9205111
uniprot
proteins
pubmed
9399589
uniprot
proteins
sequence_length
505
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:23826168}. Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:P11598}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). {ECO:0000269|PubMed:12643545}.
uniprot
proteins