E2F8
entrez
79733
canonical
uniprot
A0AVK6
canonical
ensembl
ENSG00000129173
resolver
ensp
ENSP00000250024
resolver
ensp
ENSP00000434199
resolver
ensp
ENSP00000481103
resolver
ensp
ENSP00000568657
resolver
ensp
ENSP00000636301
resolver
ensp
ENSP00000636302
resolver
ensp
ENSP00000745372
resolver
enst
ENST00000250024
resolver
enst
ENST00000527884
resolver
enst
ENST00000620009
resolver
enst
ENST00000966242
resolver
genesymbol
E2F8
resolver
hgnc
HGNC:24727
resolver
uniprot
A8K9H3
resolver
uniprot
Q2VPJ3
resolver
uniprot
Q3C1U6
resolver
uniprot
Q5BKY4
resolver
uniprot
Q8N340
resolver
uniprot
Q9H5M0
resolver
uniprot_entry
E2F8_HUMAN
resolver
uniprot_sec
A8K9H3
resolver
uniprot_sec
Q2VPJ3
resolver
uniprot_sec
Q3C1U6
resolver
uniprot_sec
Q5BKY4
resolver
uniprot_sec
Q8N340
resolver
uniprot_sec
Q9H5M0
resolver
amino_acid_sequence
MENEKENLFCEPHKRGLMKTPLKESTTANIVLAEIQPDFGPLTTPTKPKEGSQGEPWTPTANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEAKDCIHEHLSGDEFEKSQPSRKEKSLGLLCHKFLARYPNYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHMVSRLAKNRYTWHGRHNLNKTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFIKSYSIEDHIIKSNTGPNGHPDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEVAAKILIGEDHVEDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTGPEISPNTSGSSPVIHFTPSDLEVRRSSKENCAKNLFSTRGKPNFTRHPSLIKLVKSIESDRRKINSAPSSPIKTNKAESSQNSAPFPSKMAQLAAICKMQLEEQSSESRQKVKVQLARSGPCKPVAPLDPPVNAEMELTAPSLIQPLGMVPLIPSPLSSAVPLILPQAPSGPSYAIYLQPTQAHQSVTPPQGLSPTVCTTHSSKATGSKDSTDATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAGERGSKRASMLEDSGSKKKFKEDLKGLENVSATLFPSGYLIPLTQCSSLGAESILSGKENSSALSPNHRIYSSPIAGVIPVTSSELTAVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALASSHPVPIQNPSSAIVNFTLQHLGLISPNVQLSASPGSGIVPVSPRIESVNVAPENAGTQQGRATNYDSPVPGQSQPNGQSVAVTGAQQPVPVTPKGSQLVAESFFRTPGGPTKPTSSSCMDFEGANKTSLGTLFVPQRKLEVSTEDVH
uniprot
proteins
function
FUNCTION: Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. {ECO:0000269|PubMed:15897886, ECO:0000269|PubMed:16179649, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:22903062}.
uniprot
proteins
mass_dalton
94166
uniprot
proteins
mutagenesis
MUTAGEN 156; /note="R->A: Loss of DNA-binding and inhibition of E2F1-dependent activation. Impairs DNA-binding and dimerization; when associated with A-314."; /evidence="ECO:0000269|PubMed:15897886, ECO:0000269|PubMed:18202719"; MUTAGEN 314; /note="R->A: Loss of DNA-binding and inhibition of E2F1-dependent activation. Impairs DNA-binding and dimerization; when associated with A-156."; /evidence="ECO:0000269|PubMed:15897886, ECO:0000269|PubMed:18202719
uniprot
proteins
protein_family
E2F/DP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15897886
uniprot
proteins
pubmed
16179649
uniprot
proteins
pubmed
18194653
uniprot
proteins
pubmed
18202719
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
22802528
uniprot
proteins
pubmed
22903062
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
867
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15897886}.
uniprot
proteins