Cdca7
entrez
311742
canonical
uniprot
Q4KM91
canonical
ensembl
ENSRNOG00000001514
resolver
ensembl
ENSRNOG00055024819
resolver
ensembl
ENSRNOG00060002735
resolver
ensembl
ENSRNOG00065017334
resolver
ensp
ENSRNOP00000099715
resolver
ensp
ENSRNOP00055034961
resolver
ensp
ENSRNOP00060003085
resolver
ensp
ENSRNOP00065022869
resolver
enst
ENSRNOT00055042810
resolver
enst
ENSRNOT00060004386
resolver
enst
ENSRNOT00065028902
resolver
genesymbol
Cdca7
resolver
uniprot_entry
CDCA7_RAT
resolver
amino_acid_sequence
MEARRARQKALKVKNLKNVRYMKLISVETSSSSDDSCDSFASDNFANTRLQFNREGCRTRSQCRPSGPLRVAMKFPARNTRRAANTKAAPPKPSESSANDSHSESDSEEEEDGMNFLEKRALNIKQNKAMLAKLMSELESFPGIFSGRHSLPGHRTKDSKSPRRRTFPGVASRRNPERRARPLTRSRSRILGSLGALPTEEEEDEEEEEDKYMLVRRRKSVDGYMNDDDVSRSRRPGSMTLPHIIRPVEDVTEEEIRNICSNSREKIYNRSLGSTCHQCRQKTTDTKTNCRNPDCWGIRGQFCGPCLRNRYGEEVKDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQA
uniprot
proteins
function
FUNCTION: Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis (PubMed:11598121). Also functions as a critical cofactor for the chromatin remodeler HELLS, facilitating its recruitment to specific genomic regions to maintain DNA methylation patterns and heterochromatin integrity. Recognizes hemimethylated CpG within nucleosomes where it recruits HELLS to remodel chromatin and facilitate access of de novo DNA methyltransferases to heterochromatic regions, enabling proper establishment of DNA methylation patterns. May play a role as transcriptional regulator (By similarity). {ECO:0000250|UniProtKB:Q9BWT1, ECO:0000269|PubMed:11598121}.
uniprot
proteins
mass_dalton
43024
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-166 promotes interaction with YWHAE and YWHAZ, dissociation from MYC and sequestration in the cytoplasm. {ECO:0000250|UniProtKB:Q9BWT1}.
uniprot
proteins
pubmed
11598121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BWT1}. Cytoplasm {ECO:0000250|UniProtKB:Q9BWT1}. Chromosome {ECO:0000250|UniProtKB:Q9BWT1}. Note=Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-166. {ECO:0000250|UniProtKB:Q9BWT1}.
uniprot
proteins