Bag1
entrez
12017
canonical
uniprot
Q60739
canonical
ensembl
ENSMUSG00000028416
resolver
ensp
ENSMUSP00000030125
resolver
ensp
ENSMUSP00000103724
resolver
enst
ENSMUST00000030125
resolver
genesymbol
Bag1
resolver
uniprot
F6TCF9
resolver
uniprot
Q561N1
resolver
uniprot
Q6IS45
resolver
uniprot
Q9CUY1
resolver
uniprot
Q9D7K6
resolver
uniprot_entry
BAG1_MOUSE
resolver
uniprot_entry
F6TCF9_MOUSE
resolver
uniprot_entry
Q9CUY1_MOUSE
resolver
uniprot_sec
Q561N1
resolver
uniprot_sec
Q6IS45
resolver
uniprot_sec
Q9D7K6
resolver
amino_acid_sequence
MAGRSAARRPRGDREPLGPRLRAPRPAREPRQSESRAERGLPPSQRSSVRSAASGHDRSTRGAPAGACKPRVKKKVRPRSSQSEKVGSSSRELTRSKKVTRSKNVTGTQVEEVTKIEEATQTEEVTVAEEVTQTDNMAKTEEMVQTEEMETPRLSVIVTHSNERYDLLVTPQQGNSEPVVQDLAQLVEEATGVPLPFQKLIFKGKSLKEMETPLSALGMQNGCRVMLIGEKSNPEEEVELKKLKDLEVSAEKIANHLQELNKELSGIQQGFLAKELQAEALCKLDRKVKATIEQFMKILEEIDTMVLPEQFKDSRLKRKNLVKKVQVFLAECDTVEQYICQETERLQSTNLALAE
uniprot
proteins
function
FUNCTION: Co-chaperone for HSP70 and HSC70 chaperone proteins (PubMed:9873016). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli (By similarity). Involved in the STUB1-mediated proteasomal degradation of ESR1 in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity). {ECO:0000250|UniProtKB:B0K019, ECO:0000250|UniProtKB:Q99933, ECO:0000269|PubMed:9873016}.
uniprot
proteins
mass_dalton
39740
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. {ECO:0000305|PubMed:11257006}.
uniprot
proteins
pubmed
11257006
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7834747
uniprot
proteins
pubmed
9396724
uniprot
proteins
pubmed
9679980
uniprot
proteins
pubmed
9873016
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
uniprot
proteins