Dctn1
entrez
13191
canonical
uniprot
O08788
canonical
ensembl
ENSMUSG00000031865
resolver
ensp
ENSMUSP00000076623
resolver
ensp
ENSMUSP00000109540
resolver
ensp
ENSMUSP00000109546
resolver
ensp
ENSMUSP00000109552
resolver
ensp
ENSMUSP00000237530
resolver
ensp
ENSMUSP00000237531
resolver
ensp
ENSMUSP00000237534
resolver
ensp
ENSMUSP00000237539
resolver
ensp
ENSMUSP00000237540
resolver
ensp
ENSMUSP00000237548
resolver
ensp
ENSMUSP00000237552
resolver
enst
ENSMUST00000077407
resolver
enst
ENSMUST00000113907
resolver
enst
ENSMUST00000113913
resolver
genesymbol
Dctn1
resolver
uniprot
D3YX34
resolver
uniprot
E9Q3M3
resolver
uniprot
E9Q586
resolver
uniprot
E9QLJ1
resolver
uniprot
Q3TRF1
resolver
uniprot
Q3TZG7
resolver
uniprot
Q6NZM3
resolver
uniprot_entry
D3YX34_MOUSE
resolver
uniprot_entry
DCTN1_MOUSE
resolver
uniprot_entry
E9Q3M3_MOUSE
resolver
uniprot_entry
E9Q586_MOUSE
resolver
uniprot_entry
Q3TRF1_MOUSE
resolver
uniprot_entry
Q6NZM3_MOUSE
resolver
uniprot_sec
E9QLJ1
resolver
uniprot_sec
Q3TZG7
resolver
amino_acid_sequence
MAQSRRHMSSRTPSGSRMSTEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGADAAAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGPSSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRSEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFDLSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDSTMQLADHIKFTQSALDCMGVEVGRLRAFLQGGQEATDIALLLRDLETSCSDTRQFCKKIRRRMPGTDAPGIPAALAFGSQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLPVAALEELAFKASEQIYGSPSSSPYECLRQSCTILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLDETQTLLRKKEKDFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEPQRGGAPGQAPGALPGPGLVKDSPLLLQQISAMRLHISQLQHENSILRGAQMKASLAALPPLHVAKLSLPPHEGPGGNLVAGALYRKTSQLLEKLNQLSTHTHVVDITRSSPAAKSPSAQLMEQVAQLKSLSDTIEKLKDEVLKETVTQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLGQRHRLVLTQEQLHQLHSRLIS
uniprot
proteins
function
FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon. Plays a role in metaphase spindle orientation. Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole. Plays a role in primary cilia formation (By similarity). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000250|UniProtKB:Q14203}.
uniprot
proteins
mass_dalton
141676
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:Q14203}.; PTM: Phosphorylation by SLK at Thr-145, Thr-146 and Thr-147 targets DCTN1 to the centrosome. It is uncertain if SLK phosphorylates all three threonines or one or two of them. PLK1-mediated phosphorylation at Ser-179 is essential for its localization in the nuclear envelope and promotes its dissociation from microtubules during early mitosis and positively regulates nuclear envelope breakdown during prophase. {ECO:0000250|UniProtKB:Q14203}.
uniprot
proteins
protein_family
Dynactin 150 kDa subunit family
uniprot
proteins
pubmed
14581450
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16954346
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19935774
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22275436
uniprot
proteins
pubmed
22956769
uniprot
proteins
pubmed
23386061
uniprot
proteins
pubmed
25189619
uniprot
proteins
pubmed
27474409
uniprot
proteins
pubmed
30787442
uniprot
proteins
pubmed
9070275
uniprot
proteins
sequence_length
1281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14203}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16954346}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q14203}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23386061}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q14203}. Nucleus envelope {ECO:0000250|UniProtKB:Q14203}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q14203}. Note=Localizes to microtubule plus ends. Localizes preferentially to the ends of tyrosinated microtubules (PubMed:16954346). Localization at centrosome is regulated by SLK-dependent phosphorylation. Localizes to centrosome in a PARKDA-dependent manner. PLK1-mediated phosphorylation at Ser-179 is essential for its localization in the nuclear envelope (By similarity). Localizes to the subdistal appendage region of the centriole in a KIF3A-dependent manner (PubMed:23386061). {ECO:0000250|UniProtKB:Q14203, ECO:0000269|PubMed:16954346, ECO:0000269|PubMed:23386061}.
uniprot
proteins