P42893
uniprot
P42893
canonical
activity_regulation
ACTIVITY REGULATION: Inhibited by phosphoramidon. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MGSLRPPQGLGLQWSSFFLGKKGPGLTVSLPLLASSLQVNFRSPRSGQRCWAARTSVEKRLVVLVTLLAAGLVACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASASEAEKKAQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYPVEINESEPIVVYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSLRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW
uniprot
proteins
ec_number
3.4.24.71
uniprot
proteins
function
FUNCTION: Converts big endothelin-1 to endothelin-1.
uniprot
proteins
mass_dalton
86126
uniprot
proteins
mutagenesis
MUTAGEN 420; /note="C->S: Loss of dimerization."; /evidence="ECO:0000269|PubMed:8645169"; MUTAGEN 600; /note="E->Q: Loss of activity."; /evidence="ECO:0000269|PubMed:8645169"; MUTAGEN 659; /note="E->Q: Loss of activity."; /evidence="ECO:0000269|PubMed:8645169"; MUTAGEN 724; /note="H->Q: Loss of activity."; /evidence="ECO:0000269|PubMed:8645169
uniprot
proteins
protein_family
Peptidase M13 family
uniprot
proteins
pubmed
10491078
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7672114
uniprot
proteins
pubmed
8034569
uniprot
proteins
pubmed
8645169
uniprot
proteins
sequence_length
762
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10491078, ECO:0000269|PubMed:8645169}; Single-pass type II membrane protein {ECO:0000269|PubMed:10491078, ECO:0000269|PubMed:8645169}.
uniprot
proteins
transmembrane_region
TRANSMEM 61..81; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins