HGS
entrez
9146
canonical
uniprot
O14964
canonical
ensembl
ENSG00000185359
resolver
ensp
ENSP00000331201
resolver
genesymbol
HGS
resolver
genesymbol_syn
HRS
resolver
hgnc
HGNC:4897
resolver
uniprot
A0A0S2Z4R4
resolver
uniprot
Q9NR36
resolver
uniprot_entry
A0A0S2Z4R4_HUMAN
resolver
uniprot_entry
HGS_HUMAN
resolver
uniprot_sec
Q9NR36
resolver
amino_acid_sequence
MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASSAPPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQPGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFVNRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVEGSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAYSSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPSQDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD
uniprot
proteins
function
FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
uniprot
proteins
mass_dalton
86192
uniprot
proteins
mutagenesis
MUTAGEN 266; /note="A->Q: Strongly reduced ubiquitin-binding. Reduced degradation of ubiquitinated EGFR."; /evidence="ECO:0000269|PubMed:16462748"; MUTAGEN 268; /note="A->Q: Strongly reduced ubiquitin-binding. Reduced degradation of ubiquitinated EGFR."; /evidence="ECO:0000269|PubMed:16462748
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylation occurs in response to EGF, IL-2, GM-CSF and HGF. {ECO:0000250|UniProtKB:Q99LI8}.; PTM: Ubiquitinated (PubMed:25588945). Ubiquitinated by ITCH (PubMed:14602072, PubMed:24790097). {ECO:0000269|PubMed:14602072, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:25588945}.
uniprot
proteins
pubmed
10861283
uniprot
proteins
pubmed
12551915
uniprot
proteins
pubmed
12900394
uniprot
proteins
pubmed
14602072
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15509564
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15772161
uniprot
proteins
pubmed
16159959
uniprot
proteins
pubmed
16462748
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18675823
uniprot
proteins
pubmed
18987736
uniprot
proteins
pubmed
19278655
uniprot
proteins
pubmed
19296456
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21070952
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23166352
uniprot
proteins
pubmed
23208550
uniprot
proteins
pubmed
23236378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24790097
uniprot
proteins
pubmed
25588945
uniprot
proteins
pubmed
9252367
uniprot
proteins
pubmed
9407053
uniprot
proteins
pubmed
9630564
uniprot
proteins
sequence_length
777
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9JJ50}. Early endosome membrane {ECO:0000269|PubMed:23166352, ECO:0000269|PubMed:24790097}; Peripheral membrane protein {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}; Cytoplasmic side {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:Q9JJ50}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JJ50}. Note=Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments. {ECO:0000269|PubMed:16159959}.
uniprot
proteins