Slc30a1
entrez
58976
canonical
uniprot
Q62720
canonical
ensembl
ENSRNOG00000004749
resolver
ensembl
ENSRNOG00055003340
resolver
ensembl
ENSRNOG00055010951
resolver
ensembl
ENSRNOG00060013793
resolver
ensembl
ENSRNOG00065004149
resolver
ensp
ENSRNOP00000006340
resolver
ensp
ENSRNOP00055003844
resolver
ensp
ENSRNOP00055014919
resolver
ensp
ENSRNOP00060018706
resolver
ensp
ENSRNOP00065004318
resolver
enst
ENSRNOT00000006340
resolver
enst
ENSRNOT00055005186
resolver
enst
ENSRNOT00055018537
resolver
enst
ENSRNOT00060023550
resolver
enst
ENSRNOT00065006041
resolver
genesymbol
Slc30a1
resolver
genesymbol_syn
Znt1
resolver
uniprot_entry
ZNT1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Calcium-dependent. {ECO:0000269|PubMed:24951051}.
uniprot
proteins
amino_acid_sequence
MGCWGRNRGRLLCMLLLTFMFMVLEVVVSRVTASLAMLSDSFHMLSDVLALVVALVAERFARRTHATQKNTFGWIRAEVMGALVNAIFLTGLCFAILLEAVERFIEPHEMQQPLVVLSVGVAGLLVNVLGLCLFHHHSGEGQGAGHGHSHGHGHGHLAKGARKAGRAGGEAGAPPGRAPDQEPDQEETNTLVANTSNSNGLKADQAEPEKLRSDDPVDVQVNGNLIQESDSLESEDNRAGQLNMRGVFLHVLGDALGSVIVVVNALVFYFSWKGCTEDDFCVNPCFPDPCKSSVELMNSTQAPMHEAGPCWVLYLDPTLCIIMVCILLYTTYPLLKESALILLQTVPKQIDIKHLVKELRDVEGVEEVHELHVWQLAGSRIIATAHIKCEDPASYMQVAKTIKDVFHNHGIHATTIQPEFASVGSKSSVVPCELACRTQCALKQCCGTRPQVHSGKEAEKAPTVSISCLELSENLEKKPRRTKAEGSVPAVVIEIKNVPNKQPESSL
uniprot
proteins
function
FUNCTION: Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:19095042, PubMed:24951051, PubMed:7882967, PubMed:28091657). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (PubMed:15378655, PubMed:16741752, PubMed:19767393, PubMed:28091657). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (By similarity). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (By similarity). Down-regulates the activity of transcription factors induced by zinc and cytokines (By similarity). Also functions as a copper transporter, facilitating the entry of copper into cells, which is crucial for copper-induced cell death (cuproptosis) (By similarity). Acts as a Zn(2+)/Ca(2+) exchanger, exporting zinc in exchange for calcium influx (By similarity). {ECO:0000250|UniProtKB:Q9Y6M5, ECO:0000269|PubMed:15378655, ECO:0000269|PubMed:16741752, ECO:0000269|PubMed:19095042, ECO:0000269|PubMed:19767393, ECO:0000269|PubMed:24951051, ECO:0000269|PubMed:28091657, ECO:0000269|PubMed:7882967}.
uniprot
proteins
mass_dalton
55143
uniprot
proteins
mutagenesis
MUTAGEN 43; /note="H->A: No effect on homodimerization. Loss of zinc export across plasma membrane, no effect on localization to the plasma membrane and interaction with CACNB2; alone or when associated with A-254."; /evidence="ECO:0000269|PubMed:24951051, ECO:0000269|PubMed:28091657"; MUTAGEN 254; /note="D->A: No effect on homodimerization. Loss of zinc export across plasma membrane, no effect on localization to the plasma membrane and interaction with CACNB2; alone or when associated with A-43."; /evidence="ECO:0000269|PubMed:24951051, ECO:0000269|PubMed:28091657
uniprot
proteins
protein_family
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
uniprot
proteins
protein_family
SLC30A subfamily
uniprot
proteins
pubmed
15378655
uniprot
proteins
pubmed
16741752
uniprot
proteins
pubmed
19095042
uniprot
proteins
pubmed
19767393
uniprot
proteins
pubmed
24951051
uniprot
proteins
pubmed
28091657
uniprot
proteins
pubmed
7882967
uniprot
proteins
pubmed
9560190
uniprot
proteins
sequence_length
507
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24951051, ECO:0000269|PubMed:28091657, ECO:0000269|PubMed:7882967}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:24951051}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9Y6M5}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y6M5}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y6M5}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Y6M5}; Multi-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:Q9Y6M5}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic density {ECO:0000250|UniProtKB:Q60738}. Note=Localization to the plasma membrane is regulated by cellular zinc status. Recruitment to the plasma membrane from an internal pool is stimulated by zinc while in absence of zinc the plasma membrane pool is endocytosed and degraded (By similarity). Localizes to the basolateral surface of enterocytes (PubMed:24951051). Localizes to zinc-containing intracellular vesicles in macrophages (By similarity). Localizes in the cytoplasm and to the ER, Golgi and nucleus membranes in keratinocytes (By similarity). {ECO:0000250|UniProtKB:Q9Y6M5, ECO:0000269|PubMed:24951051}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 248..268; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 308..328; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins