Gpr142
entrez
217302
canonical
uniprot
Q7TQN9
canonical
ensembl
ENSMUSG00000034677
resolver
ensp
ENSMUSP00000045029
resolver
ensp
ENSMUSP00000102194
resolver
enst
ENSMUST00000045319
resolver
enst
ENSMUST00000106584
resolver
genesymbol
Gpr142
resolver
uniprot
A0A1C9J7L2
resolver
uniprot
F6ZW85
resolver
uniprot
Q1XA02
resolver
uniprot_entry
A0A1C9J7L2_MOUSE
resolver
uniprot_entry
F6ZW85_MOUSE
resolver
uniprot_entry
GP142_MOUSE
resolver
uniprot_entry
Q1XA02_MOUSE
resolver
amino_acid_sequence
MHLNSNPNSYICDAYQHADLLWSLSPHVLTKAVQPQVTLLPTVNGSNPRYDGVDGHWPESPERSPCVAGIIPVIYYSVLLSLGLPVALARLAARTRKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFRATVRQVICDVHMACALKSQPKQTVVELMLKSVGTEL
uniprot
proteins
function
FUNCTION: Highly selective G protein-coupled receptor for aromatic amino acids specifically L-Tryptophan (L-Trp) and L-Phenylalanine (L-Phe), with L-Trp being the most potent and efficacious agonist (PubMed:27104960, PubMed:27322810, PubMed:30472415). GPR142 agonists triggers the activation of both GNAQ/G(q) and GNAI1/G(i)signaling pathways (PubMed:27104960). L-Trp stimulates glucose-induced insulin secretion and triggers G(q)-mediated signaling (PubMed:27104960). GPR142 appears to have a role as a sensor of aromatic essential amino acids controlling the secretion of both insulin in the pancreas and other gastrointestinal hormones including glucagon but also CCK and incretin in the gastrointestinal-tract, contributing to the control of glucose homeostasis by coordinating pancreatic and gut hormone secretion (PubMed:27104960, PubMed:27322810, PubMed:30472415). {ECO:0000269|PubMed:27104960, ECO:0000269|PubMed:27322810, ECO:0000269|PubMed:30472415}.
uniprot
proteins
mass_dalton
40758
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14623098
uniprot
proteins
pubmed
27104960
uniprot
proteins
pubmed
27322810
uniprot
proteins
pubmed
27807998
uniprot
proteins
pubmed
30472415
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 67..87; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 141..161; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins