S1pr2
entrez
14739
canonical
uniprot
P52592
canonical
ensembl
ENSMUSG00000043895
resolver
ensp
ENSMUSP00000053394
resolver
ensp
ENSMUSP00000258855
resolver
enst
ENSMUST00000054197
resolver
genesymbol
S1pr2
resolver
genesymbol_syn
Edg5
resolver
genesymbol_syn
Gpcr13
resolver
genesymbol_syn
Lpb2
resolver
uniprot
Q8C3Q7
resolver
uniprot
Q9R236
resolver
uniprot_entry
S1PR2_MOUSE
resolver
uniprot_sec
Q8C3Q7
resolver
uniprot_sec
Q9R236
resolver
amino_acid_sequence
MGGLYSEYLNPEKVLEHYNYTKETLDMQETTSRKVASAFIIILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGHVTLSLTPVQWFAREGSAFITLSASVFSLLAIAIERQVALAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCLNQLEACSTVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSSHADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVLRPLQCWRRGKGVTGRRGGNPGHRLLPLRSSSSLERGMHMPTSPTFLEGNTVV
uniprot
proteins
function
FUNCTION: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (By similarity). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (By similarity). Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). In lymphoid follicles, couples the binding of S1P to the activation of GNA13 and downstream inhibition of AKT activation leading to suppression of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:O95136, ECO:0000250|UniProtKB:P47752}.
uniprot
proteins
mass_dalton
38829
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
8288218
uniprot
proteins
pubmed
9931453
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O95136}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..59; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 67..95; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 110..128; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 148..173; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 190..210; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 234..255; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 272..292; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins