Krt17
entrez
287702
canonical
uniprot
Q6IFU8
canonical
ensembl
ENSRNOG00000026371
resolver
ensembl
ENSRNOG00055033278
resolver
ensembl
ENSRNOG00060023919
resolver
ensembl
ENSRNOG00065032498
resolver
ensp
ENSRNOP00000005382
resolver
ensp
ENSRNOP00055047399
resolver
ensp
ENSRNOP00060034364
resolver
ensp
ENSRNOP00065046049
resolver
enst
ENSRNOT00000005382
resolver
enst
ENSRNOT00055057507
resolver
enst
ENSRNOT00060041473
resolver
enst
ENSRNOT00065055919
resolver
genesymbol
Krt17
resolver
genesymbol_syn
Ka17
resolver
uniprot_entry
K1C17_RAT
resolver
amino_acid_sequence
MTTTIRQFTSSSSIKGSSGLGGGSSRTSCRLSGSLGAGSCRLGSASGLGSALGGNSYSSCYSFGTGSGYGGNFGGVDGLLAGGEKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQKQAPGPARDYSAYYQTIEDLKNKILVATVDNASILLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVGGEINVEMDAAPGVDLSRILSEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGSLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKPKEPVTTRQVRTIVEEVQDGKVISSREQVHQTTR
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in epithelial keratinocytes. Forms heteropolymers with type II keratins KRT6A and KRT6B, assembling into keratin filament networks that contribute to the structural integrity and specialized differentiation of various epithelial appendages, including nail and hair follicle (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. Promotes epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation (By similarity). {ECO:0000250|UniProtKB:Q04695, ECO:0000250|UniProtKB:Q9QWL7}.
uniprot
proteins
mass_dalton
48123
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization. {ECO:0000250}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15085952
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
433
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QWL7}.
uniprot
proteins