Add3
entrez
27360
canonical
uniprot
Q9QYB5
canonical
ensembl
ENSMUSG00000025026
resolver
ensp
ENSMUSP00000025999
resolver
ensp
ENSMUSP00000052245
resolver
ensp
ENSMUSP00000107370
resolver
ensp
ENSMUSP00000157955
resolver
ensp
ENSMUSP00000158149
resolver
ensp
ENSMUSP00000158154
resolver
ensp
ENSMUSP00000182522
resolver
ensp
ENSMUSP00000182574
resolver
ensp
ENSMUSP00000182575
resolver
ensp
ENSMUSP00000182582
resolver
genesymbol
Add3
resolver
genesymbol_syn
Addl
resolver
uniprot
Q3UNK1
resolver
uniprot
Q8BM29
resolver
uniprot
Q8JZT6
resolver
uniprot
Q9D2M5
resolver
uniprot
Q9QYB6
resolver
uniprot_entry
ADDG_MOUSE
resolver
uniprot_entry
Q3UNK1_MOUSE
resolver
uniprot_entry
Q8BM29_MOUSE
resolver
uniprot_sec
Q8JZT6
resolver
uniprot_sec
Q9D2M5
resolver
uniprot_sec
Q9QYB6
resolver
amino_acid_sequence
MSSDTSPAVVTTPPPPSMPHKERYFDRINESDPEYLRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPSGLLALQQIADYIVTSSFSGFSSPSLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLADLFGWAHLANTYISVRISKEQDHIIIIPRGLSFSEATASTLVKVNIIGEVVDQGSTDLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLILGDVAYYDYQGSLDEEEERIELQKVLGPSCKVLVLRNHGMVALGETLEEAFHYIFNVQMACEIQVQAVAGAGGVDNLLVLDLQKYKAFTHGVAMSGGGGVNMASHQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLVREKPRHKSDVEIPATVTAFSFEDDSAPLSPLKFMAQRQQREKTRWLNSPNTYMKVNVPEESRNGETSPRTKITWMKAEDSSKVSSGTPIKIEDPNQFVPLNTNPTEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSTMQFDDDDQGPPAPPNPFSHLLEGELEEYTKTIERKQQGLDDAEQGSLSDDAASVSQIQSQTQSPQSVPERLEENHELFSKSFTSMDAPVMIMNGKDEMHDVEDELAQRVSRLTTSTTIENIEITIKSPERTEEVLSPDGSPSKSPSKKKKKFRTPSFLKKNKKKEKVEA
uniprot
proteins
function
FUNCTION: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin (By similarity). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (PubMed:33992672). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9UEY8, ECO:0000269|PubMed:33992672}.
uniprot
proteins
mass_dalton
78777
uniprot
proteins
mutagenesis
MUTAGEN 357; /note="N->A: Loss of cleavage by asparagine endopeptidase (AEP)."; /evidence="ECO:0000269|PubMed:33992672"; MUTAGEN 450; /note="N->A: No effect on cleavage by asparagine endopeptidase (AEP)."; /evidence="ECO:0000269|PubMed:33992672"; MUTAGEN 457; /note="N->A: No effect on cleavage by asparagine endopeptidase (AEP)."; /evidence="ECO:0000269|PubMed:33992672
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000250}.; PTM: Proteolytically cleaved by asparagine endopeptidase (AEP) into 2 fragments. Overexpression of the 1-357 fragment induces neuronal apoptosis, and overexpression of either 1-357 or 358-706 fragment increases the degeneration of dendritic spines. Overexpression of the 1-357 fragment impairs neurite outgrowth by down-regulating the expression of Rac2, and induces synaptic dysfunction and cognitive impairments in tau P301S transgenic mice, a mouse model for Alzheimer disease (AD). {ECO:0000269|PubMed:33992672}.
uniprot
proteins
protein_family
Adducin subfamily
uniprot
proteins
protein_family
Aldolase class II family
uniprot
proteins
pubmed
10602987
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16682971
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33992672
uniprot
proteins
sequence_length
706
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q62847}. Cell membrane {ECO:0000250|UniProtKB:Q62847}; Peripheral membrane protein; Cytoplasmic side. Cytoplasm {ECO:0000269|PubMed:33992672}. Note=Full-length protein and the cleavage fragment 358-706 localize mainly to the cytoplasm, while cleavage fragment 1-357 translocates from the cytoplasm to the nucleus. {ECO:0000269|PubMed:33992672}.
uniprot
proteins