HTR4
entrez
3360
canonical
uniprot
Q13639
canonical
ensembl
ENSG00000164270
resolver
ensp
ENSP00000353915
resolver
ensp
ENSP00000367120
resolver
ensp
ENSP00000427913
resolver
ensp
ENSP00000428320
resolver
ensp
ENSP00000430979
resolver
ensp
ENSP00000435904
resolver
genesymbol
HTR4
resolver
hgnc
HGNC:5299
resolver
uniprot
A0A2D3FAF9
resolver
uniprot
C4WYH4
resolver
uniprot
Q546Q1
resolver
uniprot
Q684M0
resolver
uniprot
Q712M9
resolver
uniprot
Q96KH9
resolver
uniprot
Q96KI0
resolver
uniprot
Q9H199
resolver
uniprot
Q9NY73
resolver
uniprot
Q9UBM6
resolver
uniprot
Q9UBT4
resolver
uniprot
Q9UE22
resolver
uniprot
Q9UE23
resolver
uniprot
Q9UQR6
resolver
uniprot_entry
5HT4R_HUMAN
resolver
uniprot_entry
A0A2D3FAF9_HUMAN
resolver
uniprot_sec
C4WYH4
resolver
uniprot_sec
Q546Q1
resolver
uniprot_sec
Q684M0
resolver
uniprot_sec
Q712M9
resolver
uniprot_sec
Q96KH9
resolver
uniprot_sec
Q96KI0
resolver
uniprot_sec
Q9H199
resolver
uniprot_sec
Q9NY73
resolver
uniprot_sec
Q9UBM6
resolver
uniprot_sec
Q9UBT4
resolver
uniprot_sec
Q9UE22
resolver
uniprot_sec
Q9UE23
resolver
uniprot_sec
Q9UQR6
resolver
amino_acid_sequence
MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:10821780, PubMed:16102731, PubMed:35714614, PubMed:9603189). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:16102731, PubMed:35714614). HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:16102731, PubMed:35714614). {ECO:0000269|PubMed:10821780, ECO:0000269|PubMed:16102731, ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:9603189}.
uniprot
proteins
mass_dalton
43761
uniprot
proteins
mutagenesis
MUTAGEN 100; /note="D->A: Abolished G protein-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 100; /note="D->N: In D3.32N mutant; abolihed binding to serotonin."; /evidence="ECO:0000269|PubMed:10821780"; MUTAGEN 104; /note="T->A: Decreased G protein-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 105; /note="T->A: Abolished G protein-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 186; /note="F->A: Decreased G protein-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 193; /note="A->F,V: Decreased G protein-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 197; /note="S->A: In S5.43A mutant; abolihed binding to serotonin."; /evidence="ECO:0000269|PubMed:10821780"; MUTAGEN 272; /note="W->A: Abolished G protein-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 275; /note="Missing: Abolished G protein-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 302; /note="Y->A: In Y7.43A mutant; abolihed binding to serotonin. Abolished G protein-coupled receptor activity."; /evidence="ECO:0000269|PubMed:10821780, ECO:0000269|PubMed:35714614
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10220570
uniprot
proteins
pubmed
10646498
uniprot
proteins
pubmed
10821780
uniprot
proteins
pubmed
11750916
uniprot
proteins
pubmed
15118808
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16102731
uniprot
proteins
pubmed
19661922
uniprot
proteins
pubmed
22197934
uniprot
proteins
pubmed
35714614
uniprot
proteins
pubmed
7656980
uniprot
proteins
pubmed
9351641
uniprot
proteins
pubmed
9603189
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10821780}; Multi-pass membrane protein {ECO:0000269|PubMed:35714614}. Endosome membrane {ECO:0000250|UniProtKB:P97288}; Multi-pass membrane protein {ECO:0000269|PubMed:35714614}. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with NHERF1 and EZR might target the protein to specialized subcellular regions, such as microvilli. {ECO:0000250|UniProtKB:P97288}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..44; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:35714614, ECO:0007744|PDB:7XT8, ECO:0007744|PDB:7XT9, ECO:0007744|PDB:7XTA"; TRANSMEM 55..78; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:35714614, ECO:0007744|PDB:7XT8, ECO:0007744|PDB:7XT9, ECO:0007744|PDB:7XTA"; TRANSMEM 93..117; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:35714614, ECO:0007744|PDB:7XT8, ECO:0007744|PDB:7XT9, ECO:0007744|PDB:7XTA"; TRANSMEM 134..157; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:35714614, ECO:0007744|PDB:7XT8, ECO:0007744|PDB:7XT9, ECO:0007744|PDB:7XTA"; TRANSMEM 189..212; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:35714614, ECO:0007744|PDB:7XT8, ECO:0007744|PDB:7XT9, ECO:0007744|PDB:7XTA"; TRANSMEM 258..283; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:35714614, ECO:0007744|PDB:7XT8, ECO:0007744|PDB:7XT9, ECO:0007744|PDB:7XTA"; TRANSMEM 291..314; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:35714614, ECO:0007744|PDB:7XT8, ECO:0007744|PDB:7XT9, ECO:0007744|PDB:7XTA
uniprot
proteins