Nt5c2
entrez
100363253
canonical
uniprot
D3ZMY7
canonical
ensembl
ENSRNOG00000020179
resolver
ensembl
ENSRNOG00055003734
resolver
ensembl
ENSRNOG00060029685
resolver
ensembl
ENSRNOG00065030938
resolver
ensp
ENSRNOP00000080847
resolver
ensp
ENSRNOP00000096997
resolver
ensp
ENSRNOP00055004507
resolver
ensp
ENSRNOP00060043401
resolver
ensp
ENSRNOP00065044057
resolver
enst
ENSRNOT00000103587
resolver
enst
ENSRNOT00000109706
resolver
enst
ENSRNOT00055005980
resolver
enst
ENSRNOT00060052178
resolver
enst
ENSRNOT00065053608
resolver
genesymbol
Nt5c2
resolver
uniprot
A0A8I6GLV2
resolver
uniprot_entry
5NTC_RAT
resolver
uniprot_entry
A0A8I6GLV2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by various compounds including ATP, 2,3-BPG/2,3-Bisphosphoglyceric acid and Ap4A/P1,P4-bis(5'-adenosyl) tetraphosphate (PubMed:6260203). Binding of an allosteric activator is a prerequisiste to magnesium and substrate binding (By similarity). Inhibited by inorganic phosphate (PubMed:6260203). {ECO:0000250|UniProtKB:P49902, ECO:0000269|PubMed:6260203}.
uniprot
proteins
amino_acid_sequence
MMTSWSDRLQNAADVPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFELTVERLVSIGYPQELLNFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLVCAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTSCDTGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMKEVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAAHVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLAPQEITHCHDEDDDEEEEEEE
uniprot
proteins
ec_number
2.7.1.77
uniprot
proteins
ec_number
3.1.3.5
uniprot
proteins
ec_number
3.1.3.99
uniprot
proteins
function
FUNCTION: Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:6260203). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (By similarity). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:6260203). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (By similarity). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:6260203). {ECO:0000250|UniProtKB:P49902, ECO:0000269|PubMed:6260203}.
uniprot
proteins
mass_dalton
64866
uniprot
proteins
protein_family
5'(3')-deoxyribonucleotidase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
6260203
uniprot
proteins
sequence_length
560
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49902}.
uniprot
proteins