Sp110
entrez
109032
canonical
uniprot
Q8BVK9
canonical
ensembl
ENSMUSG00000070034
resolver
ensp
ENSMUSP00000091226
resolver
ensp
ENSMUSP00000179147
resolver
ensp
ENSMUSP00000179148
resolver
ensp
ENSMUSP00000350066
resolver
enst
ENSMUST00000093508
resolver
genesymbol
Sp110
resolver
genesymbol_syn
Ifi75
resolver
genesymbol_syn
Ipr1
resolver
uniprot
Q05D41
resolver
uniprot
Q3UCV7
resolver
uniprot
Q80V00
resolver
uniprot_entry
SP110_MOUSE
resolver
uniprot_sec
Q05D41
resolver
uniprot_sec
Q3UCV7
resolver
uniprot_sec
Q80V00
resolver
amino_acid_sequence
MFTLTKALEKALLQHFIYMKVNIAYAINKPFPFFEALRDNSFITERMYKESLEACQNLVPLSKVVHNILTSLEQTFHPSVLLTLFSKVNLREYPSLVAIFRSFRNVGYTYEEKNRPPLTLLEDLANPAEGCSLQTLLPPPRPQISLPSHLSSAPRVCDPRATAQPIIEILDEQPSPSPRAVPLLGCIQEGKTTPVSSRDHQRKDKEDSREMPHSPSGPESVVKDDSPAANDLEMAREVPCTPANKKARRKKRPNWSNSKRRRQKKKPRQDEMMGVASPGHGVQEKLKAVSRRTLWKDDSSTNVKEVTKTQRTRMRRAQTSNSQEISKEASKTSGRKRPSTARRTTQVPEKTKNDAVDFSPTLPVTCGKAKGTLFQEKLKQGASKKCIQNEAGDWLTVKEFLNEGGRATSKDWKGVIRCNGETLRHLEQKGLLFFTSKSKPQKKGA
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Sp110 are a cause of severely impaired resistance to infection by M.tuberculosis. {ECO:0000269|PubMed:15815631}.
uniprot
proteins
function
FUNCTION: May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells. {ECO:0000269|PubMed:15815631}.
uniprot
proteins
mass_dalton
50140
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815631
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00185, ECO:0000255|PROSITE-ProRule:PRU00747}.
uniprot
proteins