Slc5a12
entrez
241612
canonical
uniprot
Q49B93
canonical
ensembl
ENSMUSG00000041644
resolver
ensp
ENSMUSP00000047340
resolver
ensp
ENSMUSP00000106655
resolver
genesymbol
Slc5a12
resolver
genesymbol_syn
Smct2
resolver
uniprot
B9EJ03
resolver
uniprot
Q0D2G1
resolver
uniprot
Q6A4K8
resolver
uniprot_entry
B9EJ03_MOUSE
resolver
uniprot_entry
SC5AC_MOUSE
resolver
uniprot_sec
Q0D2G1
resolver
uniprot_sec
Q6A4K8
resolver
amino_acid_sequence
MRVKNFEAWDYVVFAGLFVISSGIGVFFAIKERKKTTSREFLVGGRQMSFGPVALSLTASFMSAVTVLGTPAEVYRFGASFFLFLISYVFVVFFTSELFLPVFYRSGITSTYEYLQLRFNKPVRYAATIIYIVQTILYTGVVVYAPALALNQVTGFNLWASVFATGIVCTFYCSLGGLKAVVWTDAFQMVVMIVGFLTVLIQGSNHVGGFNNVLEKAGNGSRLHIVDFDVDPLRRHTFWTITIGGTFTWLGVYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIIVACAVFSGLIMYSHFKDCDPWTSGVISAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVAASINALATVTFEDFVKSCFPHLSDKLSTWISKGLCILFGIMCTSMAVVASLMGSVVQAALSIHGMCGGPMLGLFTLGLVFPFVNWKGALGGLLTGITLSFWVAIGSFIYPAPESKTLPLPLSTEHCVELNITTTVAPQISSRPVLADTWYSLSYLYFSAVGCLGCIAAGIIISFLTGKQRGKDIDPLLIRPVCNLFCFWSKKYKTLCWCGVQHDRETEQDYLDSGSAWKQGVESGLQNGLKQDTLAQIPGYNPKEKSYSNSVPEKTTYF
uniprot
proteins
function
FUNCTION: Acts as an electroneutral and low-affinity sodium Na(+)-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina. Probably part of D-serine transport systems involved in D-serine reabsorption at the brush border of renal proximal tubules. {ECO:0000250|UniProtKB:Q1EHB4, ECO:0000269|PubMed:16104846, ECO:0000269|PubMed:16873376}.
uniprot
proteins
mass_dalton
67951
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16104846
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16873376
uniprot
proteins
pubmed
17591909
uniprot
proteins
pubmed
17692818
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
619
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:16873376, ECO:0000269|PubMed:17692818}; Multi-pass membrane protein {ECO:0000269|PubMed:16873376, ECO:0000269|PubMed:17692818}. Note=Detected at the brush border membrane of the kidney. Colocalizes with vimentin in Mueller cells. {ECO:0000269|PubMed:16873376, ECO:0000269|PubMed:17692818}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 48..68; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 81..101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 129..149; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 181..201; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 276..296; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 322..342; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 386..406; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 412..432; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 438..458; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 505..525; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins