FSTL1
entrez
11167
canonical
uniprot
Q12841
canonical
ensembl
ENSG00000163430
resolver
ensp
ENSP00000295633
resolver
genesymbol
FSTL1
resolver
genesymbol_syn
FRP
resolver
hgnc
HGNC:3972
resolver
uniprot
A8K523
resolver
uniprot
B4DTT5
resolver
uniprot
D3DN90
resolver
uniprot
Q549Z0
resolver
uniprot_entry
FSTL1_HUMAN
resolver
uniprot_sec
A8K523
resolver
uniprot_sec
B4DTT5
resolver
uniprot_sec
D3DN90
resolver
uniprot_sec
Q549Z0
resolver
amino_acid_sequence
MWKRWLALALALVAVAWVRAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQTEEEMTRYVQELQKHQETAEKTKRVSTKEI
uniprot
proteins
function
FUNCTION: Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (PubMed:22265692, PubMed:29212066). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (By similarity). Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (PubMed:20054002, PubMed:22265692). {ECO:0000250|UniProtKB:Q62356, ECO:0000269|PubMed:20054002, ECO:0000269|PubMed:22265692, ECO:0000269|PubMed:29212066}.
uniprot
proteins
mass_dalton
34986
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15638044
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
20054002
uniprot
proteins
pubmed
20860622
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22265692
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
29212066
uniprot
proteins
pubmed
7957230
uniprot
proteins
pubmed
9786430
uniprot
proteins
sequence_length
308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins