Hnrnpa1
entrez
15382
canonical
uniprot
P49312
canonical
ensembl
ENSMUSG00000046434
resolver
ensp
ENSMUSP00000042658
resolver
ensp
ENSMUSP00000084609
resolver
ensp
ENSMUSP00000154865
resolver
enst
ENSMUST00000036004
resolver
enst
ENSMUST00000230489
resolver
genesymbol
Hnrnpa1
resolver
genesymbol_syn
Fli-2
resolver
genesymbol_syn
Hnrpa1
resolver
genesymbol_syn
Tis
resolver
uniprot
A0A2R8VH95
resolver
uniprot
P97312
resolver
uniprot
Q3V269
resolver
uniprot
Q5EBP8
resolver
uniprot_entry
A0A2R8VH95_MOUSE
resolver
uniprot_entry
Q5EBP8_MOUSE
resolver
uniprot_entry
ROA1_MOUSE
resolver
uniprot_sec
P97312
resolver
uniprot_sec
Q3V269
resolver
amino_acid_sequence
MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF
uniprot
proteins
function
FUNCTION: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. May bind to specific miRNA hairpins. {ECO:0000250|UniProtKB:P09651}.
uniprot
proteins
mass_dalton
34196
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000250}.
uniprot
proteins
pubmed
1406633
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
8912629
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P09651}. Cytoplasm {ECO:0000250|UniProtKB:P09651}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. {ECO:0000250|UniProtKB:P09651}.
uniprot
proteins