Nppc
entrez
18159
canonical
uniprot
Q61839
canonical
ensembl
ENSMUSG00000026241
resolver
ensp
ENSMUSP00000027449
resolver
enst
ENSMUST00000027449
resolver
genesymbol
Nppc
resolver
genesymbol_syn
Cnp
resolver
uniprot
Q544K5
resolver
uniprot_entry
ANFC_MOUSE
resolver
uniprot_entry
Q544K5_MOUSE
resolver
amino_acid_sequence
MHLSQLIACALLLALLSLRPSEAKPGTPPKVPRTPPGEELADSQAAGGNQKKGDKTPGSGGANLKGDRSRLLRDLRVDTKSRAAWARLLHEHPNARKYKGGNKKGLSKGCFGLKLDRIGSMSGLGC
uniprot
proteins
function
FUNCTION: [CNP-22]: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (PubMed:11259675). May also be vasoactive and natriuretic (By similarity). Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed:12890708). Binds the clearance receptor NPR3 (By similarity). {ECO:0000250|UniProtKB:P23582, ECO:0000269|PubMed:11259675, ECO:0000269|PubMed:12890708}.
uniprot
proteins
mass_dalton
13320
uniprot
proteins
post_translational_modification
PTM: [CNP-22]: Degraded by IDE (in vitro). {ECO:0000250|UniProtKB:P23582}.
uniprot
proteins
protein_family
Natriuretic peptide family
uniprot
proteins
pubmed
11259675
uniprot
proteins
pubmed
12890708
uniprot
proteins
pubmed
7698765
uniprot
proteins
pubmed
8897953
uniprot
proteins
sequence_length
126
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins