MTCH2
entrez
23788
canonical
uniprot
Q9Y6C9
canonical
ensembl
ENSG00000109919
resolver
ensembl
ENSG00000285121
resolver
ensp
ENSP00000303222
resolver
ensp
ENSP00000432043
resolver
ensp
ENSP00000494421
resolver
ensp
ENSP00000495027
resolver
ensp
ENSP00000662864
resolver
ensp
ENSP00000662870
resolver
ensp
ENSP00000780459
resolver
ensp
ENSP00000780460
resolver
enst
ENST00000302503
resolver
enst
ENST00000530428
resolver
enst
ENST00000642838
resolver
enst
ENST00000643223
resolver
genesymbol
MTCH2
resolver
genesymbol_syn
MIMP
resolver
hgnc
HGNC:17587
resolver
uniprot
B2R7L8
resolver
uniprot
B4DHQ0
resolver
uniprot
E9PIE4
resolver
uniprot_entry
B4DHQ0_HUMAN
resolver
uniprot_entry
E9PIE4_HUMAN
resolver
uniprot_entry
MTCH2_HUMAN
resolver
uniprot_sec
B2R7L8
resolver
amino_acid_sequence
MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLPPTIGRNIFGRQVCQLPGLFSYAQHIASIDGRRGLFTGLTPRLCSGVLGTVVHGKVLQHYQESDKGEELGPGNVQKEVSSSFDHVIKETTREMIARSAATLITHPFHVITLRSMVQFIGRESKYCGLCDSIITIYREEGILGFFAGLVPRLLGDILSLWLCNSLAYLVNTYALDSGVSTMNEMKSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGCPPYSPIYTSWIDCWCMLQKEGNMSRGNSLFFRKVPFGKTYCCDLKMLI
uniprot
proteins
function
FUNCTION: Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed:36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (PubMed:36264797). Does not mediate insertion of beta-barrel transmembrane proteins (PubMed:36264797). Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (By similarity). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (By similarity). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (By similarity). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (By similarity). {ECO:0000250|UniProtKB:Q791V5, ECO:0000269|PubMed:36264797}.
uniprot
proteins
mass_dalton
33331
uniprot
proteins
mutagenesis
MUTAGEN 25; /note="K->E: Hyperactive mutant with enhanced protein insertase activity."; /evidence="ECO:0000269|PubMed:36264797"; MUTAGEN 189; /note="D->R: Abolished protein insertase activity."; /evidence="ECO:0000269|PubMed:36264797
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
12407445
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
36264797
uniprot
proteins
pubmed
40105103
uniprot
proteins
sequence_length
303
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:36264797}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 78..92; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 181..199; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 281..303; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins