Fads2
entrez
83512
canonical
uniprot
Q9Z122
canonical
ensembl
ENSRNOG00000020440
resolver
ensembl
ENSRNOG00055017917
resolver
ensembl
ENSRNOG00060030734
resolver
ensembl
ENSRNOG00065033960
resolver
ensp
ENSRNOP00000027756
resolver
ensp
ENSRNOP00000088570
resolver
ensp
ENSRNOP00055024411
resolver
ensp
ENSRNOP00060044387
resolver
ensp
ENSRNOP00065048010
resolver
enst
ENSRNOT00000027756
resolver
enst
ENSRNOT00000120292
resolver
enst
ENSRNOT00055030351
resolver
enst
ENSRNOT00060053425
resolver
enst
ENSRNOT00065058334
resolver
genesymbol
Fads2
resolver
genesymbol_syn
Fadsd6
resolver
uniprot
A0A8I6A6F8
resolver
uniprot
H2BF31
resolver
uniprot_entry
A0A8I6A6F8_RAT
resolver
uniprot_entry
FADS2_RAT
resolver
uniprot_sec
H2BF31
resolver
amino_acid_sequence
MGKGGNQGEGSTELQAPMPTFRWEEIQKHNLRTDRWLVIDRKVYNVTKWSQRHPGGHRVIGHYSGEDATDAFRAFHLDLDFVGKFLKPLLIGELAPEEPSLDRGKSSQITEDFRALKKTAEDMNLFKTNHLFFFLLLSHIIVMESIAWFILSYFGNGWIPTVITAFVLATSQAQAGWLQHDYGHLSVYKKSIWNHIVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDIKSLHVFVLGEWQPLEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIRRRDWVDLAWAISYYARFFYTYIPFYGILGALVFLNFIRFLESHWFVWVTQMNHIVMEIDLDHYRDWFSSQLAATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIVSSLKKSGELWLDAYLHK
uniprot
proteins
ec_number
1.14.19.3
uniprot
proteins
function
FUNCTION: Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (PubMed:10049752, PubMed:11988075, PubMed:14563830, PubMed:22216341, PubMed:24070791). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (PubMed:11988075). It can also desaturate (11E)-octadecenoate (trans-vaccenoate) at carbon 6 generating (6Z,11E)-octadecadienoate (PubMed:24070791). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity). {ECO:0000250|UniProtKB:B8R1K0, ECO:0000269|PubMed:10049752, ECO:0000269|PubMed:11988075, ECO:0000269|PubMed:14563830, ECO:0000269|PubMed:22216341, ECO:0000269|PubMed:24070791}.
uniprot
proteins
mass_dalton
52380
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO:0000305|PubMed:11988075, ECO:0000305|PubMed:24070791}.
uniprot
proteins
protein_family
Fatty acid desaturase type 1 family
uniprot
proteins
pubmed
10049752
uniprot
proteins
pubmed
11988075
uniprot
proteins
pubmed
12538079
uniprot
proteins
pubmed
14563830
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22216341
uniprot
proteins
pubmed
24070791
uniprot
proteins
pubmed
5094766
uniprot
proteins
sequence_length
444
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000269|PubMed:11988075}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 131..151; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 306..326; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins