Ankrd27
entrez
245886
canonical
uniprot
Q3UMR0
canonical
ensembl
ENSMUSG00000034867
resolver
ensp
ENSMUSP00000041751
resolver
ensp
ENSMUSP00000140259
resolver
ensp
ENSMUSP00000140554
resolver
enst
ENSMUST00000186245
resolver
genesymbol
Ankrd27
resolver
genesymbol_syn
Varp
resolver
uniprot
A0A0R4J2C4
resolver
uniprot
Q6KAU0
resolver
uniprot
Q6P1F9
resolver
uniprot
Q7TNY8
resolver
uniprot
Q8BUD2
resolver
uniprot
Q91W65
resolver
uniprot_entry
A0A0R4J2C4_MOUSE
resolver
uniprot_entry
ANR27_MOUSE
resolver
uniprot_sec
Q6KAU0
resolver
uniprot_sec
Q6P1F9
resolver
uniprot_sec
Q7TNY8
resolver
uniprot_sec
Q8BUD2
resolver
uniprot_sec
Q91W65
resolver
amino_acid_sequence
MALYDEDLLKNPFYLALQKWRPDLCSKVAQIHGIVLVPCRGSLPGSVQASCQFESYVLVPTEGHFQTLDGKAVVIEGNRIKLGAGFACLLSVPILFEETFYNEKEESFSILCIAHPLERRETSEEPSAPADPFSLKTIEDVREFLGRHSEKFDKNIASFHRTFRECERKSLRHHIDSVNALYTKCLQQLLRDSHLKVLAKQEAQMNLMKQAVEMYVHHDIYDLIFKYVGTMEASEDAAFNKITRSLQDLQQKDIGVKPEFSFNIPRAKRELGQLNKCTSPQQKLLCLRKVVQLMTQSPSQRVNLETMCADDLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSSAKDELGYCLTSVEAAIEYIRQGSLSTKTPDAEGFGDRLFLKQRMNLLSQMTSTPIDCLFKHIASGNQKEVERLLSQDDQDKDAMQKMCHPLCSCEDCEKLISGRLNDPSVVTPFSRDDRGQTPLHVAALCGQASLIDFLVSKGAVVNATDYHGSTPLHLACQKGFQSVTLLLLHYKASTEVQDNNGNTPLHLACTYGQEDCVKALVYYDVQACRLDIGNEKGDTALHIAARWGYEGIIETLLQNGAPTAVQNRLKETPLKCALNSKILSIMEAHHLSSDRRPRPSEVPAQSPTRSVDSISQGSSTSSFSSISVSFRQEEVKKDYREVEKLLRAVADGDLEMVRYLLEWTEDDLDDVEDAISTVDLEFCHPLCQCPKCAPAQKLARISANGLSVNVTNQDGFSPLHMAALHGRTDLVPLLLKHGAYSGARNTSQAVPLHLACQQGHFQVAKCLLDSNAKPNKKDLSGNTPLICACSAGHHEVAALLLQHGASINACNNKGNTALHEAVMGRHTLVVELLLFYGASVDILNKRQYTAADCAEQDSKIMELLQVVPGCVASLDSVEEADHEGYVTVEIRRKWNPKMYNLPEEPLRRQFCLINPGGRFQERTSRETMGRDRSVPDLAGRSLQEPEKQRVTGKQSDLSDLSRYQTSEEGNKGLPERPVSRQAAPGHRPMVRRHTVNDAAILQVPEVTVHLTTHEASVPQS
uniprot
proteins
function
FUNCTION: May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (By similarity). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (By similarity). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (PubMed:19403694, PubMed:21187289). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (PubMed:19745841, PubMed:22171327). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1. Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (By similarity). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (By similarity). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (PubMed:26620560). {ECO:0000250|UniProtKB:Q96NW4, ECO:0000269|PubMed:19403694, ECO:0000269|PubMed:21187289, ECO:0000269|PubMed:26620560}.
uniprot
proteins
mass_dalton
116809
uniprot
proteins
mutagenesis
MUTAGEN 310; /note="D->A: Inhibits dendrite formation."; /evidence="ECO:0000269|PubMed:22171327"; MUTAGEN 350; /note="Y->A: Inhibits dendrite formation."; /evidence="ECO:0000269|PubMed:22171327"; MUTAGEN 509; /note="Q->A: Disrupts interaction with RAB32 and RAB38; inhibits peripheral distribution of TYRP1 in melanocytes; no effect on dendrite formation in melanocytes."; /evidence="ECO:0000269|PubMed:21187289, ECO:0000269|PubMed:22171327"; MUTAGEN 550; /note="Y->A: Disrupts interaction with RAB32 and RAB38; inhibits peripheral distribution of TYRP1 in melanocytes; no effect on dendrite formation in melanocytes."; /evidence="ECO:0000269|PubMed:21187289, ECO:0000269|PubMed:22171327"; MUTAGEN 575; /note="W->A: Impairs interaction with RAB32 and RAB38."; /evidence="ECO:0000269|PubMed:21187289"; MUTAGEN 577; /note="Y->A: Impairs interaction with RAB32 and RAB38."; /evidence="ECO:0000269|PubMed:21187289
uniprot
proteins
pubmed
15449545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16525121
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19403694
uniprot
proteins
pubmed
19745841
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21187289
uniprot
proteins
pubmed
22171327
uniprot
proteins
pubmed
26620560
uniprot
proteins
sequence_length
1048
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000250|UniProtKB:Q96NW4}. Late endosome {ECO:0000250|UniProtKB:Q96NW4}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q96NW4}. Lysosome {ECO:0000250|UniProtKB:Q96NW4}. Cell membrane {ECO:0000250|UniProtKB:Q96NW4}. Melanosome {ECO:0000269|PubMed:19403694}. Cytoplasmic vesicle {ECO:0000269|PubMed:19403694}. Note=Colocalizes with VAMP7 in transport vesicles in the shaft of hippocampal neurons. {ECO:0000269|PubMed:19745841}.
uniprot
proteins