Kcnk3
entrez
29553
canonical
uniprot
O54912
canonical
ensembl
ENSRNOG00000009790
resolver
ensembl
ENSRNOG00055018693
resolver
ensembl
ENSRNOG00060011772
resolver
ensembl
ENSRNOG00065023877
resolver
ensp
ENSRNOP00000079208
resolver
ensp
ENSRNOP00055025750
resolver
ensp
ENSRNOP00060015650
resolver
ensp
ENSRNOP00065033467
resolver
enst
ENSRNOT00000108628
resolver
enst
ENSRNOT00055031852
resolver
enst
ENSRNOT00060019923
resolver
enst
ENSRNOT00065040987
resolver
genesymbol
Kcnk3
resolver
genesymbol_syn
Task
resolver
genesymbol_syn
Task1
resolver
uniprot_entry
KCNK3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by extracellular acidification, muscarinic signaling, divalent metal cations Zn(2+) and Ba(2+), isoflurane, bupivacaine and phenytoin. Activated by protein kinase A. Ruthenium red resistant. {ECO:0000269|PubMed:10725353, ECO:0000269|PubMed:14678492, ECO:0000269|PubMed:15282272, ECO:0000269|PubMed:9437008}.
uniprot
proteins
amino_acid_sequence
MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPEMIERQRLELRQLELRARYNLSEGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTFVRYLLHRAKRGLGMRHAEVSMANMVLIGFVSCISTLCIGAAAFSYYERWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTHNGQAGGLGGLSCLSGSLGDGVRPRDPVTCAAAAGGMGVGVGVGGSGFRNVYAEMLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEHSHSSPGGGGRYSDTPSHPCLCSGTQRSAISSVSTGLHSLATFRGLMKRRSSV
uniprot
proteins
function
FUNCTION: K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:10725353, PubMed:15282272, PubMed:9437008). Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state (By similarity). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity) (PubMed:15282272). Allows K(+) currents with fast-gating kinetics important for the repolarization and hyperpolarization phases of action potentials (By similarity). In cerebellar granule cells, heteromeric KCNK3:KCNK9 channel may hyperpolarize the resting membrane potential to limit intrinsic neuronal excitability, but once the action potential threshold is reached, it may support high-frequency action potential firing and increased neuronal excitability (By similarity) (PubMed:14678492). Dispensable for central chemosensory respiration i.e. breathing controlled by brainstem CO2/pH, it rather conducts pH-sensitive currents and controls the firing rate of serotonergic raphe neurons involved in potentiation of the respiratory chemoreflex. Additionally, imparts chemosensitivity to type 1 cells in carotid bodies which respond to a decrease in arterial oxygen pressure or an increase in carbon dioxide pressure or pH to initiate adaptive changes in pulmonary ventilation (By similarity). In adrenal gland, contributes to the maintenance of a hyperpolarized resting membrane potential of aldosterone-producing cells at zona glomerulosa and limits aldosterone release as part of a regulatory mechanism that controls arterial blood pressure and electrolyte homeostasis (By similarity). In brown adipocytes, mediates K(+) efflux that counteracts norepinephrine-induced membrane depolarization, limits Ca(2+) efflux and downstream cAMP and PKA signaling, ultimately attenuating lipid oxidation and adaptive thermogenesis (By similarity). {ECO:0000250|UniProtKB:O14649, ECO:0000250|UniProtKB:O35111, ECO:0000269|PubMed:10725353, ECO:0000269|PubMed:14678492, ECO:0000269|PubMed:15282272, ECO:0000269|PubMed:9437008}.
uniprot
proteins
mass_dalton
45276
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
10725353
uniprot
proteins
pubmed
14678492
uniprot
proteins
pubmed
15282272
uniprot
proteins
pubmed
9437008
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:10725353}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 108..128; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 159..179; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 223..243; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins