TNFAIP8L2
entrez
79626
canonical
uniprot
Q6P589
canonical
ensembl
ENSG00000163154
resolver
ensp
ENSP00000357906
resolver
ensp
ENSP00000571290
resolver
ensp
ENSP00000571291
resolver
enst
ENST00000368910
resolver
enst
ENST00000901231
resolver
enst
ENST00000901232
resolver
genesymbol
TNFAIP8L2
resolver
hgnc
HGNC:26277
resolver
uniprot
Q6I9Y0
resolver
uniprot
Q9H2H7
resolver
uniprot
Q9H5G2
resolver
uniprot_entry
TP8L2_HUMAN
resolver
uniprot_sec
Q6I9Y0
resolver
uniprot_sec
Q9H2H7
resolver
uniprot_sec
Q9H5G2
resolver
amino_acid_sequence
MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQRVIKDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLLTECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGPDFTQHLGKICDGLRKLLDEGKL
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis (PubMed:27043859). Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression (PubMed:32188758). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Also inhibits autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (PubMed:32460619). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (By similarity). {ECO:0000250|UniProtKB:Q9D8Y7, ECO:0000269|PubMed:27043859, ECO:0000269|PubMed:32188758, ECO:0000269|PubMed:32460619}.
uniprot
proteins
mass_dalton
20556
uniprot
proteins
mutagenesis
MUTAGEN 3; /note="S->A: Complete loss of interaction with BTRC."; /evidence="ECO:0000269|PubMed:32188758
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by TAK1/MAP3K7; this phosphorylation triggers association with BTRC and subsequent ubiquitination and degradation. {ECO:0000269|PubMed:32188758}.; PTM: Ubiquitinated in a BTRC-depdent manner; leading to degradation mediated through the proteasome pathway. {ECO:0000269|PubMed:32188758}.
uniprot
proteins
protein_family
TNFAIP8 family
uniprot
proteins
protein_family
TNFAIP8L2 subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18455983
uniprot
proteins
pubmed
19079267
uniprot
proteins
pubmed
21459448
uniprot
proteins
pubmed
27043859
uniprot
proteins
pubmed
32188758
uniprot
proteins
pubmed
32460619
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21459448, ECO:0000269|PubMed:27043859, ECO:0000269|PubMed:32460619}. Nucleus {ECO:0000269|PubMed:21459448, ECO:0000269|PubMed:27043859}. Lysosome {ECO:0000269|PubMed:32460619}.
uniprot
proteins