RGS16
entrez
6004
canonical
uniprot
O15492
canonical
ensembl
ENSG00000143333
resolver
ensp
ENSP00000356529
resolver
ensp
ENSP00000568572
resolver
enst
ENST00000367558
resolver
genesymbol
RGS16
resolver
genesymbol_syn
RGSR
resolver
hgnc
HGNC:9997
resolver
uniprot
B2R4M4
resolver
uniprot
Q5VYN9
resolver
uniprot
Q99701
resolver
uniprot_entry
RGS16_HUMAN
resolver
uniprot_sec
B2R4M4
resolver
uniprot_sec
Q5VYN9
resolver
uniprot_sec
Q99701
resolver
amino_acid_sequence
MCRTLAAFPTTCLERAKEFKTRLGIFLHKSELGCDTGSTGKFEWGSKHSKENRNFSEDVLGWRESFDLLLSSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIRSATKLASRAHQIFEEFICSEAPKEVNIDHETHELTRMNLQTATATCFDAAQGKTRTLMEKDSYPRFLKSPAYRDLAAQASAASATLSSCSLDEPSHT
uniprot
proteins
function
FUNCTION: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11602604, PubMed:18434541). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals (By similarity). {ECO:0000250|UniProtKB:P97428, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:18434541}.
uniprot
proteins
mass_dalton
22749
uniprot
proteins
mutagenesis
MUTAGEN 168; /note="Y->F: 30% decrease in GAP activity."; /evidence="ECO:0000269|PubMed:11602604"; MUTAGEN 177; /note="Y->F: No effect on GAP activity."; /evidence="ECO:0000269|PubMed:11602604
uniprot
proteins
post_translational_modification
PTM: Palmitoylated on Cys-2 and/or Cys-12. {ECO:0000250|UniProtKB:P97428}.; PTM: Phosphorylated. Phosphorylation at Tyr-168 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1. {ECO:0000269|PubMed:11602604}.
uniprot
proteins
pubmed
11602604
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18434541
uniprot
proteins
pubmed
9223279
uniprot
proteins
pubmed
9469939
uniprot
proteins
sequence_length
202
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P97428}; Lipid-anchor {ECO:0000250|UniProtKB:P97428}.
uniprot
proteins