OR1A1
entrez
8383
canonical
uniprot
Q9P1Q5
canonical
ensembl
ENSG00000172146
resolver
ensp
ENSP00000492897
resolver
ensp
ENSP00000493179
resolver
enst
ENST00000641322
resolver
enst
ENST00000641732
resolver
genesymbol
OR1A1
resolver
hgnc
HGNC:8179
resolver
uniprot
A5D914
resolver
uniprot
Q6IFM1
resolver
uniprot
Q6NTA9
resolver
uniprot
Q96R87
resolver
uniprot_entry
OR1A1_HUMAN
resolver
uniprot_sec
A5D914
resolver
uniprot_sec
Q6IFM1
resolver
uniprot_sec
Q6NTA9
resolver
uniprot_sec
Q96R87
resolver
activity_regulation
ACTIVITY REGULATION: Highly activated by synthetic agonists with bis-acetylene rods combined with an aryl spacer, such as aryl bis-acetylene. {ECO:0000269|PubMed:40523847}.
uniprot
proteins
amino_acid_sequence
MRENNQSSTLEFILLGVTGQQEQEDFFYILFLFIYPITLIGNLLIVLAICSDVRLHNPMYFLLANLSLVDIFFSSVTIPKMLANHLLGSKSISFGGCLTQMYFMIALGNTDSYILAAMAYDRAVAISRPLHYTTIMSPRSCIWLIAGSWVIGNANALPHTLLTASLSFCGNQEVANFYCDITPLLKLSCSDIHFHVKMMYLGVGIFSVPLLCIIVSYIRVFSTVFQVPSTKGVLKAFSTCGSHLTVVSLYYGTVMGTYFRPLTNYSLKDAVITVMYTAVTPMLNPFIYSLRNRDMKAALRKLFNKRISS
uniprot
proteins
function
FUNCTION: Olfactory receptor activated by various compounds, such as 3-methyl-2,4-nonanedione, dihydrojasmone, citronellol and carvone (PubMed:17601748, PubMed:27642093, PubMed:27916747, PubMed:28656349, PubMed:35686936). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha protein GNAL/G(olf), mediating activation of adenylate cyclase activity and increased production of cAMP, initiating a neuronal response that triggers the perception of a smell (PubMed:27916747). Acts as a selective receptor for 3-methyl-2,4-nonanedione, a key food odorant associated with a prune note in oxidized wine and is an aroma determinant in tea and apricots (PubMed:27916747). Also responds specifically to certain nitromusks, notably musk ambrette, and to a lesser extent, musk tibetene and musk xylene (PubMed:29632183). {ECO:0000269|PubMed:17601748, ECO:0000269|PubMed:27642093, ECO:0000269|PubMed:27916747, ECO:0000269|PubMed:28656349, ECO:0000269|PubMed:29632183, ECO:0000269|PubMed:35686936}.
uniprot
proteins
mass_dalton
34565
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="G->A: Abolished activation by citronellol. Abolished activation by carvone; when associated with A-152."; /evidence="ECO:0000269|PubMed:17601748, ECO:0000269|PubMed:28656349"; MUTAGEN 109; /note="N->K: Abolished activation by citronellol."; /evidence="ECO:0000269|PubMed:17601748"; MUTAGEN 152; /note="G->A: Abolished activation by carvone; when associated with A-152."; /evidence="ECO:0000269|PubMed:28656349"; MUTAGEN 251; /note="Y->F: Abolished activation by musk tibetene."; /evidence="ECO:0000269|PubMed:29632183"; MUTAGEN 258; /note="Y->F: Abolished activation by musk tibetene."; /evidence="ECO:0000269|PubMed:29632183
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10673334
uniprot
proteins
pubmed
12213199
uniprot
proteins
pubmed
14983052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17601748
uniprot
proteins
pubmed
27642093
uniprot
proteins
pubmed
27916747
uniprot
proteins
pubmed
28656349
uniprot
proteins
pubmed
29632183
uniprot
proteins
pubmed
35686936
uniprot
proteins
pubmed
40523847
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17601748, ECO:0000269|PubMed:27642093}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..49; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 58..79; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 101..120; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 140..158; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 196..218; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 236..258; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 271..290; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins