Ankle1
entrez
234396
canonical
uniprot
A8VU90
canonical
ensembl
ENSMUSG00000046295
resolver
ensp
ENSMUSP00000112797
resolver
ensp
ENSMUSP00000113162
resolver
ensp
ENSMUSP00000213835
resolver
genesymbol
Ankle1
resolver
genesymbol_syn
Ankrd41
resolver
genesymbol_syn
Lem3
resolver
uniprot
A6H5W1
resolver
uniprot
G5E8T1
resolver
uniprot
Q8C4V5
resolver
uniprot
Q8K2N6
resolver
uniprot_entry
ANKL1_MOUSE
resolver
uniprot_sec
A6H5W1
resolver
uniprot_sec
G5E8T1
resolver
uniprot_sec
Q8C4V5
resolver
uniprot_sec
Q8K2N6
resolver
amino_acid_sequence
MADTACLALRLLAALREEEARAVEELLRLGADPNLVLDDGAAAVHLAARASHPRALHCLRMLLRWGADPNARSAEGLTPVHVAAAWGCCGALELLLSRGGDPTLRDQDGLRPLDWALQQRHHNCARVLQELDTPTQPDETREPTETFHVAQGSFETETCQGPALAESSGVSQDSELHVHRAELEVEAVEVAVHPQSSEATENSDYSSDASFVTAVEDSLQPGRPGGALELVAGLWVTRGAVSAGKGAPNCQPQVLTLTARDTDKPVLPGDGDLGALHPHSSVPPMSDLQLLQALRALGYSPGPVTPFTRGHYLRRLQEAQASRADVGHSQELAEALRTGTIPDCQVDEEALAQCFQRLDPLKKWREGITKSSFTYLLLDPRLTKDLPARASSLTLAECLQCFVRAIFYVGKGTRARPDAHLWEAFGYHDQPRKQVCPKVRRILDIWASGRGIISLHCFQHVVAMEAYTREACLLDALGLQTLTNQKQGHYYGVVAHWPPSRRRRLGVHLLQRALLVFLAEGERELRPQDIQARG
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Structure-selective DNA endonuclease that specifically cleaves branched DNA. Processes chromatin bridges during cytokinesis by cleaving DNA, both priming TREX1-mediated resolution and directly resolving bridges. Proper processing of chromatin bridges prevents their breakage during cytokinesis, thereby reducing DNA damage, micronuclei formation, and the activation of immune responses such as the cGAS-STING pathway. Acts as a DNA tension sensor that resolves stretched chromatin bridges during cell division by cleaving mechanically stressed and supercoiled DNA. Its activity increases in response to mechanical stress and negative supercoiling, specifically cleaving both strands of negatively supercoiled DNA at higher stretching forces. {ECO:0000250|UniProtKB:Q8NAG6}.
uniprot
proteins
mass_dalton
58441
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27010503
uniprot
proteins
sequence_length
534
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8NAG6}. Nucleus {ECO:0000250|UniProtKB:Q8NAG6}. Midbody {ECO:0000250|UniProtKB:Q8NAG6}. Note=At the steady state, predominantly localizes in the cytoplasm. Localizes to the midbody in a KIF23 and PRC1-dependent manner. {ECO:0000250|UniProtKB:Q8NAG6}.
uniprot
proteins