AEBP2
entrez
121536
canonical
uniprot
Q6ZN18
canonical
ensembl
ENSG00000139154
resolver
ensp
ENSP00000266508
resolver
ensp
ENSP00000354267
resolver
ensp
ENSP00000381840
resolver
ensp
ENSP00000437983
resolver
ensp
ENSP00000681210
resolver
ensp
ENSP00000681212
resolver
genesymbol
AEBP2
resolver
hgnc
HGNC:24051
resolver
uniprot
Q59FS5
resolver
uniprot
Q6ZN62
resolver
uniprot
Q96BG3
resolver
uniprot_entry
AEBP2_HUMAN
resolver
uniprot_sec
Q59FS5
resolver
uniprot_sec
Q6ZN62
resolver
uniprot_sec
Q96BG3
resolver
amino_acid_sequence
MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ
uniprot
proteins
function
FUNCTION: Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:29499137, PubMed:31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.
uniprot
proteins
mass_dalton
54467
uniprot
proteins
protein_family
AEBP2/jing C2H2-type zinc-finger family
uniprot
proteins
pubmed
12351676
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15225548
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29499137
uniprot
proteins
pubmed
31959557
uniprot
proteins
sequence_length
517
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29499137}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000269|PubMed:29499137}.
uniprot
proteins