Pelo
entrez
294754
canonical
uniprot
Q5XIP1
canonical
ensembl
ENSRNOG00000061128
resolver
ensembl
ENSRNOG00055006386
resolver
ensembl
ENSRNOG00060014022
resolver
ensembl
ENSRNOG00065020386
resolver
ensp
ENSRNOP00000075562
resolver
ensp
ENSRNOP00055008056
resolver
ensp
ENSRNOP00060019120
resolver
ensp
ENSRNOP00065027580
resolver
enst
ENSRNOT00000091499
resolver
enst
ENSRNOT00055010380
resolver
enst
ENSRNOT00060023998
resolver
enst
ENSRNOT00065034431
resolver
genesymbol
Pelo
resolver
uniprot_entry
PELO_RAT
resolver
amino_acid_sequence
MKLVRKDIEKDNAGQVTLVPEEPEDMWHTYNLVQVGDSLRASTIRKVQTESSTGSVGSNRVRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSVVLERIEQACDPAWSADVAAVVMQEGLAHVCLVTPSMTLTRAKVEVNIPRKRKGNCSQHDRALERFYEQVVQAIQRHINFEVVKCILVASPGFVREQFCDYMFQQAVKTDNKVLLENRSKFLQVHASSGHKYSLKEVLCDPTVASRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKQVERANEALAIDTLLISDELFRHQDVATRSRYVRLVDSVKENAGTVRIFSSLHVSGEQLGQLTGVAAILRFPVPELSDQEDDSSSEED
uniprot
proteins
function
FUNCTION: Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy. {ECO:0000250|UniProtKB:Q9BRX2}.
uniprot
proteins
mass_dalton
43407
uniprot
proteins
protein_family
Eukaryotic release factor 1 family
uniprot
proteins
protein_family
Pelota subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BRX2}.
uniprot
proteins