Tmcc1
entrez
330401
canonical
uniprot
Q69ZZ6
canonical
ensembl
ENSMUSG00000030126
resolver
ensp
ENSMUSP00000032222
resolver
ensp
ENSMUSP00000086285
resolver
ensp
ENSMUSP00000133665
resolver
ensp
ENSMUSP00000144971
resolver
ensp
ENSMUSP00000145456
resolver
ensp
ENSMUSP00000218572
resolver
enst
ENSMUST00000173548
resolver
genesymbol
Tmcc1
resolver
genesymbol_syn
Kiaa0779
resolver
uniprot
A0A0N4SWB9
resolver
uniprot
Q8CEF4
resolver
uniprot_entry
A0A0N4SWB9_MOUSE
resolver
uniprot_entry
TMCC1_MOUSE
resolver
uniprot_sec
Q8CEF4
resolver
amino_acid_sequence
MEPSGSEQLYEDPDPGGKSQDAEARRQTESEQKLSKMTHNALENINVIGQGLKHLFQHQRRRSSVSPHDVQQIQTDPEPEVDLDSQNACAEIDGVSTHPTALNRVLQQIRVPPKMKRGTSLHSRRGKSEAPKGSPQINRKSGQEVAAVIQSGRPRSSSTTDAPTSSSVMEIACAAGVCVPGEEATAERIERLEVSSLAQTSSAVASSTDGSIHTESVDGIPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDGGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEVQEIRETQARLEDSFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFSTLFLVAFIAFLWKHWDALFSYVDRLFSPPR
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission. Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. {ECO:0000250|UniProtKB:O94876}.
uniprot
proteins
mass_dalton
71642
uniprot
proteins
protein_family
TEX28 family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
649
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O94876}; Multi-pass membrane protein {ECO:0000255}. Note=Specifically localizes to contact sites between the endoplasmic reticulum and endosomes that are spatially and temporally linked to endosome fission. {ECO:0000250|UniProtKB:O94876}.
uniprot
proteins
transmembrane_region
TRANSMEM 588..608; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 621..641; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins