Scgb3a2
entrez
117158
canonical
uniprot
Q920H1
canonical
ensembl
ENSMUSG00000038791
resolver
ensp
ENSMUSP00000038872
resolver
ensp
ENSMUSP00000140375
resolver
ensp
ENSMUSP00000140476
resolver
genesymbol
Scgb3a2
resolver
genesymbol_syn
Pnsp1
resolver
genesymbol_syn
Ugrp1
resolver
uniprot
Q5D060
resolver
uniprot
Q920H2
resolver
uniprot
Q920H3
resolver
uniprot_entry
SG3A2_MOUSE
resolver
uniprot_sec
Q5D060
resolver
uniprot_sec
Q920H2
resolver
uniprot_sec
Q920H3
resolver
amino_acid_sequence
MKLVSIFLLVTIGICGYSATALLINRLPVVDKLPVPLDDIIPSFDPLKMLLKTLGISVEHLVTGLKKCVDELGPEASEAVKKLLEALSHLV
uniprot
proteins
function
FUNCTION: Secreted cytokine-like protein (By similarity). Binds to the scavenger receptor MARCO (By similarity). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (By similarity). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed:24213919). Seems to have anti-inflammatory effects in respiratory epithelium (PubMed:16456148, PubMed:25242865). Also has anti-fibrotic activity in lung (PubMed:24213919, PubMed:26559674). May play a role in fetal lung development and maturation (PubMed:18535256). Promotes branching morphogenesis during early stages of lung development (PubMed:18535256). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (PubMed:24514953). {ECO:0000250|UniProtKB:Q96PL1, ECO:0000269|PubMed:16456148, ECO:0000269|PubMed:18535256, ECO:0000269|PubMed:24213919, ECO:0000269|PubMed:24514953, ECO:0000269|PubMed:25242865, ECO:0000269|PubMed:26559674}.
uniprot
proteins
mass_dalton
9819
uniprot
proteins
mutagenesis
MUTAGEN 68; /note="C->S: Fails to homodimerize."; /evidence="ECO:0000269|PubMed:24213919
uniprot
proteins
protein_family
Secretoglobin family
uniprot
proteins
protein_family
UGRP subfamily
uniprot
proteins
pubmed
11682631
uniprot
proteins
pubmed
12175512
uniprot
proteins
pubmed
12406855
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16456148
uniprot
proteins
pubmed
18535256
uniprot
proteins
pubmed
24213919
uniprot
proteins
pubmed
24514953
uniprot
proteins
pubmed
25242865
uniprot
proteins
pubmed
26559674
uniprot
proteins
sequence_length
91
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11682631}.
uniprot
proteins