OAS1
entrez
4938
canonical
uniprot
P00973
canonical
ensembl
ENSG00000089127
resolver
ensp
ENSP00000202917
resolver
ensp
ENSP00000388001
resolver
ensp
ENSP00000415721
resolver
ensp
ENSP00000448790
resolver
ensp
ENSP00000449053
resolver
ensp
ENSP00000502804
resolver
ensp
ENSP00000505165
resolver
ensp
ENSP00000505786
resolver
ensp
ENSP00000506580
resolver
ensp
ENSP00000653092
resolver
ensp
ENSP00000762018
resolver
enst
ENST00000553152
resolver
enst
ENST00000675868
resolver
enst
ENST00000679971
resolver
enst
ENST00000680455
resolver
enst
ENST00000681700
resolver
genesymbol
OAS1
resolver
genesymbol_syn
OIAS
resolver
hgnc
HGNC:8086
resolver
uniprot
A0A6Q8PHR1
resolver
uniprot
A0A7P0T8F9
resolver
uniprot
A0A7P0T9Q4
resolver
uniprot
A0A7P0Z4N8
resolver
uniprot
A8K4N8
resolver
uniprot
F8VXY3
resolver
uniprot
H0YIB8
resolver
uniprot
P04820
resolver
uniprot
P29080
resolver
uniprot
P29081
resolver
uniprot
P78485
resolver
uniprot
P78486
resolver
uniprot
Q16700
resolver
uniprot
Q16701
resolver
uniprot
Q1PG42
resolver
uniprot
Q3ZM01
resolver
uniprot
Q53GC5
resolver
uniprot
Q53YA4
resolver
uniprot
Q6A1Z3
resolver
uniprot
Q6IPC6
resolver
uniprot
Q6P7N9
resolver
uniprot
Q96J61
resolver
uniprot_entry
A0A6Q8PHR1_HUMAN
resolver
uniprot_entry
A0A7P0T8F9_HUMAN
resolver
uniprot_entry
A0A7P0T9Q4_HUMAN
resolver
uniprot_entry
A0A7P0Z4N8_HUMAN
resolver
uniprot_entry
H0YIB8_HUMAN
resolver
uniprot_entry
OAS1_HUMAN
resolver
uniprot_sec
A8K4N8
resolver
uniprot_sec
F8VXY3
resolver
uniprot_sec
P04820
resolver
uniprot_sec
P29080
resolver
uniprot_sec
P29081
resolver
uniprot_sec
P78485
resolver
uniprot_sec
P78486
resolver
uniprot_sec
Q16700
resolver
uniprot_sec
Q16701
resolver
uniprot_sec
Q1PG42
resolver
uniprot_sec
Q3ZM01
resolver
uniprot_sec
Q53GC5
resolver
uniprot_sec
Q53YA4
resolver
uniprot_sec
Q6A1Z3
resolver
uniprot_sec
Q6IPC6
resolver
uniprot_sec
Q6P7N9
resolver
uniprot_sec
Q96J61
resolver
activity_regulation
ACTIVITY REGULATION: Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group is tolerated (PubMed:34581622). ssRNA or dsDNA do not act as activators. {ECO:0000269|PubMed:12799444, ECO:0000269|PubMed:23319625, ECO:0000269|PubMed:34581622}.
uniprot
proteins
amino_acid_sequence
MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESNSADDETDDPRRYQKYGYIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 100 with pulmonary alveolar proteinosis and hypogammaglobulinemia (IMD100) [MIM:618042]: An autosomal dominant disorder characterized by onset of respiratory insufficiency due to pulmonary alveolar proteinosis in the first months of life. Disease development appears to be influenced or triggered by viral infection. Patients also have hypogammaglobulinemia, leukocytosis, and splenomegaly. {ECO:0000269|PubMed:29455859, ECO:0000269|PubMed:34145065, ECO:0000269|PubMed:40010341}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.7.84
uniprot
proteins
function
FUNCTION: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:34581622). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Catalyzes the formation of 2'-5'-oligoadenylates (2-5A) from polymerization of ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:34145065, PubMed:34581622, PubMed:40010341). Involved in intercellular immune signaling that limits local spread of RNA virus infection and protects against tumorigenesis (PubMed:40010341). Can generate high levels of 2',5'-oligoadenylates in transformed cells, targeting them to innate and adaptive immunesurveillance mechanisms (PubMed:40010341). Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:12799444, ECO:0000269|PubMed:18931074, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:23319625, ECO:0000269|PubMed:34145065, ECO:0000269|PubMed:34581622, ECO:0000269|PubMed:40010341}.; FUNCTION: [Isoform p46]: When prenylated at C-terminal, acts as a double-stranded RNA (dsRNA) sensor specifically targeted to membranous replicative organelles in SARS coronavirus-2/SARS-CoV-2 infected cells where it binds to dsRNA structures in the SARS-CoV-2 5'-UTR and initiates a potent block to SARS-CoV-2 replication. Recognizes short stretches of dsRNA and activates RNase L. The binding is remarkably specific, with two conserved stem loops in the SARS-CoV-2 5'- untranslated region (UTR) constituting the principal viral target (PubMed:34581622). The same mechanism is necessary to initiate a block to cardiovirus EMCV (PubMed:34581622). {ECO:0000269|PubMed:34581622}.; FUNCTION: [Isoform p42]: Not prenylated at C-terminal, is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication. {ECO:0000269|PubMed:34581622}.
uniprot
proteins
mass_dalton
46029
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="K->A: Decreased enzyme activity."; /evidence="ECO:0000269|PubMed:23319625"; MUTAGEN 75; /note="D->A: Loss of activity; when associated with A-77."; /evidence="ECO:0000269|PubMed:10464285, ECO:0000269|PubMed:25775560"; MUTAGEN 77; /note="D->A: Loss of activity; when associated with A-75."; /evidence="ECO:0000269|PubMed:10464285, ECO:0000269|PubMed:25775560"; MUTAGEN 148; /note="D->A: Strongly reduced enzyme activity."; /evidence="ECO:0000269|PubMed:23319625"; MUTAGEN 233; /note="E->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:23319625"; MUTAGEN 331; /note="C->A: Loss of activity; when associated with A-332 and A-333."; /evidence="ECO:0000269|PubMed:9407111"; MUTAGEN 332; /note="F->A: Loss of activity; when associated with A-331 and A-333."; /evidence="ECO:0000269|PubMed:9407111"; MUTAGEN 333; /note="K->A: Loss of activity; when associated with A-331 and A-332."; /evidence="ECO:0000269|PubMed:9407111"; MUTAGEN 397; /note="C->A: Not prenylated and diffusely distributed. Loss of antiviral activity."; /evidence="ECO:0000269|PubMed:34581622
uniprot
proteins
post_translational_modification
PTM: [Isoform p46]: Prenylated at C-terminal. C-terminal prenylation is necessary to initiate a block to SARS-CoV-2 and is associated with protection from severe COVID-1. The prenylated form is targeted to perinuclear structures rich in viral dsRNA, whereas the non-prenylated form is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication (Probable). C-terminal prenylation is also necessary to initiate a block to cardiovirus EMCV (Probable). {ECO:0000305|PubMed:34581622}.; PTM: [Isoform p42]: Not prenylated at C-terminal. The non-prenylated form is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication. {ECO:0000269|PubMed:34581622}.
uniprot
proteins
protein_family
2-5A synthase family
uniprot
proteins
pubmed
10464285
uniprot
proteins
pubmed
12799444
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1651324
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17024523
uniprot
proteins
pubmed
17408844
uniprot
proteins
pubmed
18931074
uniprot
proteins
pubmed
19203244
uniprot
proteins
pubmed
19904482
uniprot
proteins
pubmed
19923450
uniprot
proteins
pubmed
21142819
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23319625
uniprot
proteins
pubmed
2411547
uniprot
proteins
pubmed
2416561
uniprot
proteins
pubmed
2456211
uniprot
proteins
pubmed
25775560
uniprot
proteins
pubmed
2830497
uniprot
proteins
pubmed
29455859
uniprot
proteins
pubmed
3121313
uniprot
proteins
pubmed
33633408
uniprot
proteins
pubmed
34145065
uniprot
proteins
pubmed
34581622
uniprot
proteins
pubmed
36538032
uniprot
proteins
pubmed
3753689
uniprot
proteins
pubmed
3754863
uniprot
proteins
pubmed
39319583
uniprot
proteins
pubmed
40010341
uniprot
proteins
pubmed
6348777
uniprot
proteins
pubmed
9407111
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:3753689, ECO:0000269|PubMed:3754863}. Mitochondrion {ECO:0000269|PubMed:19923450}. Nucleus {ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:3753689}. Microsome {ECO:0000269|PubMed:19923450}. Endoplasmic reticulum {ECO:0000269|PubMed:19923450}. Secreted {ECO:0000250|UniProtKB:Q29599}. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. {ECO:0000269|PubMed:19923450}.; SUBCELLULAR LOCATION: [Isoform p46]: Note=(Microbial infection) In SARS coronavirus-2/SARS-CoV-2 infected cells, prenylated form localizes to membranous perinuclear structures reminiscent of the endoplasmic reticulum rich in viral dsRNA which are SARS-CoV-2 replicative organelles. {ECO:0000269|PubMed:34581622}.; SUBCELLULAR LOCATION: [Isoform p42]: Note=(Microbial infection) In SARS coronavirus-2/SARS-CoV-2 infected cells, since its not prenylated, is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication. {ECO:0000269|PubMed:34581622}.
uniprot
proteins