Hcn1
entrez
15165
canonical
uniprot
O88704
canonical
ensembl
ENSMUSG00000021730
resolver
ensp
ENSMUSP00000006991
resolver
enst
ENSMUST00000006991
resolver
genesymbol
Hcn1
resolver
genesymbol_syn
Bcng1
resolver
genesymbol_syn
Hac2
resolver
uniprot
O54899
resolver
uniprot
Q9D613
resolver
uniprot_entry
HCN1_MOUSE
resolver
uniprot_sec
O54899
resolver
uniprot_sec
Q9D613
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cAMP (PubMed:11459060, PubMed:22006928). cAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening (PubMed:22006928). Compared to other family members, cAMP has less stimulatory effect on HCN1 because part of the molecules already contain bound cAMP and form homotetramers when cAMP levels are low, this inherent tetramerization in HCN1 results in a weaker response to increased cAMP. {ECO:0000269|PubMed:11459060, ECO:0000269|PubMed:22006928, ECO:0000269|PubMed:9630217}.
uniprot
proteins
amino_acid_sequence
MEGGGKPNSASNSRDDGNSVFPSKAPATGPVAADKRLGTPPGGGAAGKEHGNSVCFKVDGGGGEEPAGSFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIPPINYPQMTALNCTSSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPIQSPLATRTFHYASPTASQLSLMQQPQQQLPQSQVQQTQTQTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQTPGSSTPKNEVHKSTQALHNTNLTKEVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVAAVHSTGLQAGSRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAVQRESPSVLNTDPDAEKPRFASNL
uniprot
proteins
function
FUNCTION: Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions (PubMed:12034718, PubMed:22006928, PubMed:9630217). Exhibits weak selectivity for potassium over sodium ions (PubMed:11459060). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:11459060). Participates in cerebellar mechanisms of motor learning (PubMed:14651847). May mediate responses to sour stimuli (PubMed:11675786). {ECO:0000269|PubMed:11459060, ECO:0000269|PubMed:11675786, ECO:0000269|PubMed:12034718, ECO:0000269|PubMed:14651847, ECO:0000269|PubMed:22006928, ECO:0000269|PubMed:9630217}.
uniprot
proteins
mass_dalton
102432
uniprot
proteins
mutagenesis
MUTAGEN 303; /note="C->S: Abolishes conductivity."; /evidence="ECO:0000269|PubMed:12351622"; MUTAGEN 318; /note="C->S: Abolishes sensitivity to sulfhydryl modification."; /evidence="ECO:0000269|PubMed:12351622"; MUTAGEN 349; /note="G->A: Abolishes conductivity; when associated with A-350 and A-351."; /evidence="ECO:0000269|PubMed:12089064"; MUTAGEN 350; /note="Y->A: Abolishes conductivity; when associated with A-349 and A-351."; /evidence="ECO:0000269|PubMed:12089064"; MUTAGEN 351; /note="G->A: Abolishes conductivity; when associated with A-349 and A-350."; /evidence="ECO:0000269|PubMed:12089064"; MUTAGEN 538; /note="R->E: Reduces affinity for cAMP and impairs tetramerization."; /evidence="ECO:0000269|PubMed:22006928
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:9405696}.
uniprot
proteins
protein_family
Potassium channel HCN family
uniprot
proteins
pubmed
11420311
uniprot
proteins
pubmed
11459060
uniprot
proteins
pubmed
11675786
uniprot
proteins
pubmed
12034718
uniprot
proteins
pubmed
12089064
uniprot
proteins
pubmed
12351622
uniprot
proteins
pubmed
14651847
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22006928
uniprot
proteins
pubmed
24218458
uniprot
proteins
pubmed
26269648
uniprot
proteins
pubmed
9405696
uniprot
proteins
pubmed
9630217
uniprot
proteins
pubmed
9634236
uniprot
proteins
sequence_length
910
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11459060, ECO:0000269|PubMed:22006928, ECO:0000269|PubMed:9630217}; Multi-pass membrane protein {ECO:0000269|PubMed:22006928}.
uniprot
proteins
transmembrane_region
TRANSMEM 132..153; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 163..183; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 205..225; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 250..270; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 285..307; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 361..381; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:O60741
uniprot
proteins