AKT1S1
entrez
84335
canonical
uniprot
Q96B36
canonical
ensembl
ENSG00000204673
resolver
ensp
ENSP00000341698
resolver
ensp
ENSP00000375707
resolver
ensp
ENSP00000375708
resolver
ensp
ENSP00000375710
resolver
ensp
ENSP00000375711
resolver
genesymbol
AKT1S1
resolver
genesymbol_syn
PRAS40
resolver
hgnc
HGNC:28426
resolver
uniprot
A8MTQ1
resolver
uniprot
B2RE93
resolver
uniprot
J3KPM3
resolver
uniprot
Q96BI4
resolver
uniprot
Q96IK7
resolver
uniprot
Q96NG2
resolver
uniprot
Q9BWR5
resolver
uniprot_entry
AKTS1_HUMAN
resolver
uniprot_sec
A8MTQ1
resolver
uniprot_sec
B2RE93
resolver
uniprot_sec
J3KPM3
resolver
uniprot_sec
Q96BI4
resolver
uniprot_sec
Q96IK7
resolver
uniprot_sec
Q96NG2
resolver
uniprot_sec
Q9BWR5
resolver
amino_acid_sequence
MASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIALAHRAATAARPPAPPPAPQPPSPTPSPPRPTLAREDNEEDEDEPTETETSGEQLGISDNGGLFVMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPTCSVPPASALPTQQYAKSLPVSVPVWGFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLPRPRLNTSDFQKLKRKY
uniprot
proteins
function
FUNCTION: Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:17277771, PubMed:17386266, PubMed:17510057, PubMed:29236692). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (PubMed:29236692). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (PubMed:17386266, PubMed:18372248). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (PubMed:16174443, PubMed:18372248). May also play a role in nerve growth factor-mediated neuroprotection (By similarity). {ECO:0000250|UniProtKB:Q9D1F4, ECO:0000269|PubMed:16174443, ECO:0000269|PubMed:17277771, ECO:0000269|PubMed:17386266, ECO:0000269|PubMed:17510057, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:29236692}.
uniprot
proteins
mass_dalton
27383
uniprot
proteins
mutagenesis
MUTAGEN 129; /note="F->A: Abolished association with the MTORC1 complex. Does not affect phosphorylation by MTOR."; /evidence="ECO:0000269|PubMed:17510057, ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:18372248"; MUTAGEN 183; /note="S->A: Reduced phosphorylation by MTOR."; /evidence="ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:18372248"; MUTAGEN 183; /note="S->D: Mimics phosphorylation; reduced interaction with RPTOR."; /evidence="ECO:0000269|PubMed:17517883"; MUTAGEN 212; /note="S->A: Does not affect phosphorylation by MTOR."; /evidence="ECO:0000269|PubMed:18372248"; MUTAGEN 215..225; /note="LDRIAASMRAL->ADRAAGSARAA: Abolished ability to inhibit the kinase activity of MTOR."; /evidence="ECO:0000269|PubMed:29236692"; MUTAGEN 221; /note="S->A: Decreased interaction with 14-3-3; increased inhibitory activity toward mTORC1."; /evidence="ECO:0000269|PubMed:18372248"; MUTAGEN 246; /note="T->A: Suppresses RPS6KB1 phosphorylation by mTORC1."; /evidence="ECO:0000269|PubMed:17277771, ECO:0000269|PubMed:23415227
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by AKT1; phosphorylation takes place in response to insulin treatment and promotes AKT1S1 interaction with 14-3-3 proteins, leading to relieve its inhibitor activity (PubMed:12524439, PubMed:17386266). Phosphorylated by MTOR following mTORC1 activation, inhibiting AKT1S1 inhibitor activity: phosphorylation by MTOR probably serves as a feedback loop that relieves inhibition from AKT1S1 in response to mTORC1 inactivation (PubMed:17517883). Phosphorylation at Thr-246 by DYRK3 relieves inhibitory function on mTORC1 (PubMed:23415227). {ECO:0000269|PubMed:12524439, ECO:0000269|PubMed:17386266, ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:23415227}.
uniprot
proteins
pubmed
12524439
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16174443
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17277771
uniprot
proteins
pubmed
17386266
uniprot
proteins
pubmed
17510057
uniprot
proteins
pubmed
17517883
uniprot
proteins
pubmed
18372248
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23415227
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29236692
uniprot
proteins
pubmed
29634919
uniprot
proteins
pubmed
31601764
uniprot
proteins
sequence_length
256
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9D1F4}. Note=Found in the cytosolic fraction of the brain. {ECO:0000250|UniProtKB:Q9D1F4}.
uniprot
proteins