SFXN1
entrez
94081
canonical
uniprot
Q9H9B4
canonical
ensembl
ENSG00000164466
resolver
ensp
ENSP00000316905
resolver
ensp
ENSP00000543689
resolver
ensp
ENSP00000609252
resolver
ensp
ENSP00000609253
resolver
ensp
ENSP00000609254
resolver
ensp
ENSP00000619050
resolver
ensp
ENSP00000661235
resolver
ensp
ENSP00000661238
resolver
enst
ENST00000321442
resolver
enst
ENST00000873630
resolver
enst
ENST00000939193
resolver
enst
ENST00000939194
resolver
enst
ENST00000939195
resolver
enst
ENST00000948991
resolver
genesymbol
SFXN1
resolver
hgnc
HGNC:16085
resolver
uniprot
B3KPW3
resolver
uniprot
D3DQN2
resolver
uniprot
Q9HA53
resolver
uniprot_entry
SFXN1_HUMAN
resolver
uniprot_sec
B3KPW3
resolver
uniprot_sec
D3DQN2
resolver
uniprot_sec
Q9HA53
resolver
amino_acid_sequence
MSGELPPNINIKEPRWDQSTFIGRANHFFTVTDPRNILLTNEQLESARKIVHDYRQGIVPPGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMSVTSLEAELQAKIQESHPELRRVYFNKGL
uniprot
proteins
function
FUNCTION: Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). May also transport other amino acids including alanine and cysteine (PubMed:30442778). {ECO:0000269|PubMed:30442778}.
uniprot
proteins
mass_dalton
35619
uniprot
proteins
protein_family
Sideroflexin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27184847
uniprot
proteins
pubmed
30442778
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:27184847, ECO:0000269|PubMed:30442778}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 103..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 147..167; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 175..195; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 229..249; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 267..287; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins