LY9
entrez
4063
canonical
uniprot
Q9HBG7
canonical
ensembl
ENSG00000122224
resolver
ensp
ENSP00000263285
resolver
ensp
ENSP00000357016
resolver
ensp
ENSP00000357018
resolver
ensp
ENSP00000376039
resolver
ensp
ENSP00000543907
resolver
ensp
ENSP00000543909
resolver
enst
ENST00000368039
resolver
enst
ENST00000392203
resolver
genesymbol
LY9
resolver
hgnc
HGNC:6730
resolver
uniprot
A0A0C4DFU4
resolver
uniprot
A8K7N3
resolver
uniprot
Q05CA2
resolver
uniprot
Q0VAI0
resolver
uniprot
Q14775
resolver
uniprot
Q5VYH9
resolver
uniprot
Q5VYI3
resolver
uniprot
Q6P2J4
resolver
uniprot
Q9H4N5
resolver
uniprot
Q9NQ24
resolver
uniprot_entry
A0A0C4DFU4_HUMAN
resolver
uniprot_entry
LY9_HUMAN
resolver
uniprot_entry
Q05CA2_HUMAN
resolver
uniprot_entry
Q0VAI0_HUMAN
resolver
uniprot_entry
Q5VYH9_HUMAN
resolver
uniprot_sec
A8K7N3
resolver
uniprot_sec
Q14775
resolver
uniprot_sec
Q5VYI3
resolver
uniprot_sec
Q6P2J4
resolver
uniprot_sec
Q9H4N5
resolver
uniprot_sec
Q9NQ24
resolver
amino_acid_sequence
MVAPKSHTDDWAPGPFSSKPQRSQLQIFSSVLQTSLLFLLMGLRASGKDSAPTVVSGILGGSVTLPLNISVDTEIENVIWIGPKNALAFARPKENVTIMVKSYLGRLDITKWSYSLCISNLTLNDAGSYKAQINQRNFEVTTEEEFTLFVYEQLQEPQVTMKSVKVSENFSCNITLMCSVKGAEKSVLYSWTPREPHASESNGGSILTVSRTPCDPDLPYICTAQNPVSQRSSLPVHVGQFCTDPGASRGGTTGETVVGVLGEPVTLPLALPACRDTEKVVWLFNTSIISKEREEAATADPLIKSRDPYKNRVWVSSQDCSLKISQLKIEDAGPYHAYVCSEASSVTSMTHVTLLIYRRLRKPKITWSLRHSEDGICRISLTCSVEDGGNTVMYTWTPLQKEAVVSQGESHLNVSWRSSENHPNLTCTASNPVSRSSHQFLSENICSGPERNTKLWIGLFLMVCLLCVGIFSWCIWKRKGRCSVPAFCSSQAEAPADTPEPTAGHTLYSVLSQGYEKLDTPLRPARQQPTPTSDSSSDSNLTTEEDEDRPEVHKPISGRYEVFDQVTQEGAGHDPAPEGQADYDPVTPYVTEVESVVGENTMYAQVFNLQGKTPVSQKEESSATIYCSIRKPQVVPPPQQNDLEIPESPTYENFT
uniprot
proteins
function
FUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity). {ECO:0000250|UniProtKB:Q01965, ECO:0000269|PubMed:22184727, ECO:0000269|PubMed:22989874}.
uniprot
proteins
mass_dalton
72139
uniprot
proteins
pubmed
10970093
uniprot
proteins
pubmed
11389028
uniprot
proteins
pubmed
12458214
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
22184727
uniprot
proteins
pubmed
22989874
uniprot
proteins
pubmed
26221972
uniprot
proteins
pubmed
8537117
uniprot
proteins
sequence_length
655
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 455..476; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins