Nedd9
entrez
18003
canonical
uniprot
O35177
canonical
ensembl
ENSMUSG00000021365
resolver
ensp
ENSMUSP00000021794
resolver
ensp
ENSMUSP00000125773
resolver
enst
ENSMUST00000021794
resolver
enst
ENSMUST00000163623
resolver
genesymbol
Nedd9
resolver
genesymbol_syn
Casl
resolver
uniprot
A0A0R4J212
resolver
uniprot
Q8BJL8
resolver
uniprot
Q8BK90
resolver
uniprot
Q8BL52
resolver
uniprot
Q8BM94
resolver
uniprot
Q8BMI9
resolver
uniprot
Q99KE7
resolver
uniprot_entry
A0A0R4J212_MOUSE
resolver
uniprot_entry
CASL_MOUSE
resolver
uniprot_sec
Q8BJL8
resolver
uniprot_sec
Q8BK90
resolver
uniprot_sec
Q8BL52
resolver
uniprot_sec
Q8BM94
resolver
uniprot_sec
Q8BMI9
resolver
uniprot_sec
Q99KE7
resolver
amino_acid_sequence
MWARNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPVQETPGHEQPTPGPMHQTFGQQKLYQVPNSQAASRDTIYQVPPSYQNQGIYQVPTGHGTPEQDVYQVPPSVQRNIGGTNGPLLSKKVITPVRTGHGYVYEYPSRYQKDVYDVPPSHSTQGVYDIPPSSVKGPVFSVPVGEIKPQGVYDIPPTQGVYAIPPSACRDEAGLREKEYDFPPPMKQDGKPDTRPEGVYDIPPTSTKTAGKDLHIKFPCDAPGGVEPMARRHQSFSLHHAPSQLGQSGDTQSDAYDVPRGVQFLEVPTETSEKANPEERDGVYDVPLHNPADAKGSRDVVDGINRLSFSSTGSTRSNMSTSSTSSKESSLSASPSQDKRLRLDPDTAIEKLYRLQQTLEMGVCSLMSLVTTDWRCYGYMERHINEIRTAVDKVELFLREYLHFAKGALANASCLPELVLHNKMKRELQRVEDSHQILSQTSHDLNECSWSLNILAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTISTYAETLFRADPANSHLKNGPNSIMNSSEYTHPGSQMQPLHPGDYKAQVHSKPLPPSLSKDQPPDCGSSDGSERSWMDDYDYVHLQGKEEFERQQKELLEKENIMKQSKAQLEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTTNNSVGAQDRQLLCFYYDQCETHFISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVAAQDIRNKVRNSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF
uniprot
proteins
function
FUNCTION: Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (By similarity). As a focal adhesion protein, plays a role in embryonic fibroblast migration (PubMed:25059660). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKl and SHPTP2 to the tyrosine phosphorylated form (By similarity). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:16148091, PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (PubMed:27359298). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (By similarity). Positively regulates RANKL-induced osteoclastogenesis (PubMed:27336669). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (PubMed:26683084). {ECO:0000250|UniProtKB:A0A8I3PDQ1, ECO:0000250|UniProtKB:Q14511, ECO:0000269|PubMed:16148091, ECO:0000269|PubMed:17174122, ECO:0000269|PubMed:25059660, ECO:0000269|PubMed:26683084, ECO:0000269|PubMed:27336669, ECO:0000269|PubMed:27359298}.
uniprot
proteins
mass_dalton
93052
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated by ITCH/AIP4, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q14511}.; PTM: PTK2/FAK1 phosphorylates the protein at the YDYVHL motif (conserved among all cas proteins) following integrin stimulation (By similarity). The SRC family kinases (FYN, SRC, LCK and CRK) are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues (By similarity). Ligation of either integrin beta-1 or B-cell antigen receptor on tonsillar B-cells and B-cell lines promotes tyrosine phosphorylation and both integrin and BCR-mediated tyrosine phosphorylation requires an intact actin network (By similarity). Phosphorylation is required to recruit NEDD9 to T-cell receptor microclusters at the periphery of newly formed immunological synapses (PubMed:27359298). In fibroblasts transformation with oncogene v-ABL results in an increase in tyrosine phosphorylation. Transiently phosphorylated following CD3 cross-linking and this phosphorylated form binds to CRKL and C3G (By similarity). A mutant lacking the SH3 domain is phosphorylated upon CD3 cross-linking but not upon integrin beta-1 cross-linking. Tyrosine phosphorylation occurs upon stimulation of the G protein-coupled C1a calcitonin receptor. Calcitonin-stimulated tyrosine phosphorylation is mediated by calcium- and protein kinase C-dependent mechanisms and requires the integrity of the actin cytoskeleton. Phosphorylation at Ser-368 induces proteasomal degradation (By similarity). Phosphorylated by LYN (By similarity). Phosphorylation at Ser-779 by CSNK1D or CSNK1E, or phosphorylation of Thr-803 by CSNK1E enhances the interaction of NEDD9 with PLK1 (By similarity). {ECO:0000250|UniProtKB:Q14511, ECO:0000269|PubMed:27359298}.
uniprot
proteins
protein_family
CAS family
uniprot
proteins
pubmed
10692442
uniprot
proteins
pubmed
12517963
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16148091
uniprot
proteins
pubmed
17174122
uniprot
proteins
pubmed
19103205
uniprot
proteins
pubmed
19365570
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24574519
uniprot
proteins
pubmed
25059660
uniprot
proteins
pubmed
26683084
uniprot
proteins
pubmed
27336669
uniprot
proteins
pubmed
27359298
uniprot
proteins
pubmed
29191835
uniprot
proteins
sequence_length
833
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q14511}. Nucleus {ECO:0000250|UniProtKB:Q14511}. Golgi apparatus {ECO:0000250|UniProtKB:Q14511}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q14511}. Cytoplasm {ECO:0000250|UniProtKB:Q14511}. Cell junction, focal adhesion {ECO:0000269|PubMed:25059660}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q14511}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:A0A8I3PDQ1}. Cell projection, cilium {ECO:0000250|UniProtKB:Q14511}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q14511}. Basolateral cell membrane {ECO:0000250|UniProtKB:A0A8I3PDQ1}.
uniprot
proteins