NUP50
entrez
10762
canonical
uniprot
Q9UKX7
canonical
ensembl
ENSG00000093000
resolver
ensp
ENSP00000345895
resolver
ensp
ENSP00000379403
resolver
ensp
ENSP00000385555
resolver
ensp
ENSP00000616289
resolver
genesymbol
NUP50
resolver
genesymbol_syn
NPAP60L
resolver
hgnc
HGNC:8065
resolver
uniprot
B1AHA4
resolver
uniprot
B2RB15
resolver
uniprot
B4E2D3
resolver
uniprot
E9PFD1
resolver
uniprot
O75644
resolver
uniprot
Q8N6V5
resolver
uniprot
Q9NPM9
resolver
uniprot
Q9NPR6
resolver
uniprot
Q9P1K5
resolver
uniprot_entry
B4E2D3_HUMAN
resolver
uniprot_entry
NUP50_HUMAN
resolver
uniprot_sec
B1AHA4
resolver
uniprot_sec
B2RB15
resolver
uniprot_sec
E9PFD1
resolver
uniprot_sec
O75644
resolver
uniprot_sec
Q8N6V5
resolver
uniprot_sec
Q9NPM9
resolver
uniprot_sec
Q9NPR6
resolver
uniprot_sec
Q9P1K5
resolver
amino_acid_sequence
MAKRNAEKELTDRNWDQEDEAEEVGTFSMASEEVLKNRAIKKAKRRNVGFESDTGGAFKGFKGLVVPSGGGRFSGFGSGAGGKPLEGLSNGNNITSAPPFASAKAAADPKVAFGSLAANGPTTLVDKVSNPKTNGDSQQPSSSGLASSKACVGNAYHKQLAALNCSVRDWIVKHVNTNPLCDLTPIFKDYEKYLANIEQQHGNSGRNSESESNKVAAETQSPSLFGSTKLQQESTFLFHGNKTEDTPDKKMEVASEKKTDPSSLGATSASFNFGKKVDSSVLGSLSSVPLTGFSFSPGNSSLFGKDTTQSKPVSSPFPTKPLEGQAEGDSGECKGGDEEENDEPPKVVVTEVKEEDAFYSKKCKLFYKKDNEFKEKGIGTLHLKPTANQKTQLLVRADTNLGNILLNVLIPPNMPCTRTGKNNVLIVCVPNPPIDEKNATMPVTMLIRVKTSEDADELHKILLEKKDA
uniprot
proteins
function
FUNCTION: Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}.
uniprot
proteins
mass_dalton
50144
uniprot
proteins
pubmed
10449902
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12802065
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20016008
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:12802065}. Nucleus membrane {ECO:0000250|UniProtKB:O08587}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08587}; Nucleoplasmic side {ECO:0000250|UniProtKB:O08587}. Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis (PubMed:12802065). Associates with the newly formed nuclear membrane during telophase (PubMed:12802065). In the testis, the localization changes during germ cell differentiation from the nuclear surface in spermatocytes to the whole nucleus (interior) in spermatids and back to the nuclear surface in spermatozoa (By similarity). {ECO:0000250|UniProtKB:O08587, ECO:0000269|PubMed:12802065}.
uniprot
proteins