CP
entrez
1356
canonical
uniprot
P00450
canonical
ensembl
ENSG00000047457
resolver
ensp
ENSP00000264613
resolver
ensp
ENSP00000649526
resolver
ensp
ENSP00000649528
resolver
ensp
ENSP00000649529
resolver
enst
ENST00000264613
resolver
genesymbol
CP
resolver
hgnc
HGNC:2295
resolver
uniprot
A5PL27
resolver
uniprot
Q14063
resolver
uniprot
Q2PP18
resolver
uniprot
Q9UKS4
resolver
uniprot_entry
A5PL27_HUMAN
resolver
uniprot_entry
CERU_HUMAN
resolver
uniprot_sec
Q14063
resolver
uniprot_sec
Q2PP18
resolver
uniprot_sec
Q9UKS4
resolver
amino_acid_sequence
MKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVEPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNEDTKSG
uniprot
proteins
disease_involvement
DISEASE: Aceruloplasminemia (ACEP) [MIM:604290]: An autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. {ECO:0000269|PubMed:7708681}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.11.1.27
uniprot
proteins
ec_number
1.11.1.9
uniprot
proteins
ec_number
1.16.3.1
uniprot
proteins
ec_number
1.16.3.4
uniprot
proteins
function
FUNCTION: Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane (PubMed:16150804). Copper ions provide a large number of enzymatic activities. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin (PubMed:14623105, PubMed:4643313, PubMed:5912351). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1 (By similarity). Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols (PubMed:10481051). Acts as an inhibitor of the peroxidase activity of MPO (By similarity). Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis (PubMed:16906150). {ECO:0000250|UniProtKB:P13635, ECO:0000250|UniProtKB:Q61147, ECO:0000269|PubMed:10481051, ECO:0000269|PubMed:14623105, ECO:0000269|PubMed:16150804, ECO:0000269|PubMed:16906150, ECO:0000269|PubMed:4643313, ECO:0000269|PubMed:5912351}.
uniprot
proteins
mass_dalton
122219
uniprot
proteins
protein_family
Multicopper oxidase family
uniprot
proteins
pubmed
10481051
uniprot
proteins
pubmed
10508415
uniprot
proteins
pubmed
12055353
uniprot
proteins
pubmed
14623105
uniprot
proteins
pubmed
14760718
uniprot
proteins
pubmed
15084671
uniprot
proteins
pubmed
15557511
uniprot
proteins
pubmed
16150804
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16906150
uniprot
proteins
pubmed
17242517
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19838169
uniprot
proteins
pubmed
2355023
uniprot
proteins
pubmed
23843990
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
2873574
uniprot
proteins
pubmed
29183916
uniprot
proteins
pubmed
3486416
uniprot
proteins
pubmed
3755405
uniprot
proteins
pubmed
4643313
uniprot
proteins
pubmed
5912351
uniprot
proteins
pubmed
6571985
uniprot
proteins
pubmed
6582496
uniprot
proteins
pubmed
6940148
uniprot
proteins
pubmed
6987229
uniprot
proteins
pubmed
6987230
uniprot
proteins
pubmed
7702601
uniprot
proteins
pubmed
7708681
uniprot
proteins
sequence_length
1065
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16150804}. Note=Colocalizes with GCP1 in secretory intracellular compartments. {ECO:0000250|UniProtKB:P13635}.
uniprot
proteins