Kansl3
entrez
316328
canonical
uniprot
Q3KR73
canonical
ensembl
ENSRNOG00000015417
resolver
ensp
ENSRNOP00000020955
resolver
ensp
ENSRNOP00000099135
resolver
enst
ENSRNOT00000020955
resolver
enst
ENSRNOT00000124022
resolver
genesymbol
Kansl3
resolver
genesymbol_syn
Nsl3
resolver
uniprot
A0A8L2QAX1
resolver
uniprot_entry
A0A8L2QAX1_RAT
resolver
uniprot_entry
KANL3_RAT
resolver
amino_acid_sequence
MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRMLFVTPRRQQENTIESDVPIDVETVTATPAPLYDNQKARSVMNECERHVIFARTDADAPPPPEDWEEHVNRTGWTVAQNKLFNKILKALQSDRLARLANEGACNEPVLRRVAVDKCARRVRQALASVSWDTKLIQWLHTTLVETLSLPMLAAYLDALQTLKGKIPTLIDRMLVSSNTKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIASSGPSSSVFPASRRHRFWQSQLSCLGKVIPVATHLLNNGSGVGVLQCLEHMTGAVRSKVLEIHSHFPHKPIILIGWSTGALVACHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDPLLDMKTPVLFVIGQNSLQCHPEAMEDFREKIRAENSLVVVGGADDNLRISKAKKKSEGLTQSMVDRCIQDEIVDFLTGVLTRAEGHVGSEPRDQDAEKKKKPRDVARRDLAFEIPERGSRPASPAARLPTSPSGSEDLSSVSSSPTSSPKTKGTTVTSAQKSSQIGTSQLLRRHVQRTDAVLTHRQAQVPISSEPVEEVEKEELRVQLKRHHPSSPLPGAKPSKRPKIKVSLISQGDTVGGPCTLSQGGTPEAAGGKPITMTLGASAGAKELTGLLTTAKSSSSEGGVTASAAPSVASSNATPNAIHTLQSRLVATSPGSSLPGAASASSLLQGLSFSLQDISSKTTGLPGSPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLAATPGGKPTAIHQLLTNGGLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGAAASEEPNSQMLPSSSQRLPPAP
uniprot
proteins
function
FUNCTION: Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. The NSL complex also acts as a regulator of gene expression in mitochondria. Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA. Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells. This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA. Plays an essential role in spindle assembly during mitosis. Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly. Indispensable during early embryonic development where it is required for proper lineage specification and maintenance during peri-implantation development and is essential for implantation. {ECO:0000250|UniProtKB:A2RSY1, ECO:0000250|UniProtKB:Q9P2N6}.
uniprot
proteins
mass_dalton
93035
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
877
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9P2N6}. Mitochondrion {ECO:0000250|UniProtKB:Q9P2N6}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9P2N6}. Note=Concentrated in the nucleus during interphase but displays a marked relocalization to the spindle poles during mitosis. {ECO:0000250|UniProtKB:Q9P2N6}.
uniprot
proteins