Gabrg3
entrez
79211
canonical
uniprot
P28473
canonical
ensembl
ENSRNOG00000014862
resolver
ensp
ENSRNOP00000019971
resolver
ensp
ENSRNOP00000076184
resolver
enst
ENSRNOT00000019971
resolver
enst
ENSRNOT00000093339
resolver
genesymbol
Gabrg3
resolver
uniprot
A0A0A0MXX6
resolver
uniprot_entry
A0A0A0MXX6_RAT
resolver
uniprot_entry
GBRG3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically potentiated by alphaxalone. Allosterically inhibited by pregnenolone sulfate. Inhibited by zinc and lanthanum. {ECO:0000269|PubMed:10462548}.
uniprot
proteins
amino_acid_sequence
MAAKLLLLLCLFSGLHARSRRVEEDDSEDSPSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDAHACPLTFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTTLGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTIRKKKTSLLHPDSTRWIPDRISLQAPSNYSLLDMRPPPPVMITLNNSMYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRRGRIHIDVSELDSYSRVFFPTSFLLFNLVYWVGYLYL
uniprot
proteins
function
FUNCTION: Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10462548, PubMed:1311098, PubMed:1660002). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride across the cell membrane down their electrochemical gradient (PubMed:10462548, PubMed:1311098, PubMed:1660002). {ECO:0000250|UniProtKB:P18507, ECO:0000269|PubMed:10462548, ECO:0000269|PubMed:1311098, ECO:0000269|PubMed:1660002}.
uniprot
proteins
mass_dalton
54293
uniprot
proteins
post_translational_modification
PTM: May be palmitoylated. {ECO:0000250|UniProtKB:P22723}.
uniprot
proteins
protein_family
GABRG3 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
10462548
uniprot
proteins
pubmed
1311098
uniprot
proteins
pubmed
1660002
uniprot
proteins
sequence_length
467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000255}. Cell membrane; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 257..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 284..303; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 312..332; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 447..467; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins