Plekhn1
entrez
231002
canonical
uniprot
Q8C886
canonical
ensembl
ENSMUSG00000078485
resolver
ensp
ENSMUSP00000101196
resolver
ensp
ENSMUSP00000151799
resolver
enst
ENSMUST00000105571
resolver
genesymbol
Plekhn1
resolver
genesymbol_syn
Clpabp
resolver
uniprot
A0A1W2P6Q7
resolver
uniprot
A0A1W2P7X5
resolver
uniprot
E9QP36
resolver
uniprot
Q8R3H1
resolver
uniprot_entry
E9QP36_MOUSE
resolver
uniprot_entry
PKHN1_MOUSE
resolver
uniprot_sec
A0A1W2P6Q7
resolver
uniprot_sec
A0A1W2P7X5
resolver
uniprot_sec
Q8R3H1
resolver
amino_acid_sequence
MGNSHCVPQAPRRLRASFSRKPSLKGNREDSARKLAGLFGTEARPDGDTAANRIFHYIPGTDIPGPEHHPENLEQPFLSVFKKGWRRTPVRNLGKVVHYSKVRLRFQHSQDISDCYLELFPSHLYFQAHGSEGLTFQGLLPLTELNICPTDGSREHAFQITGPLPAPLLVLCHSEAELSHWLYHLEKQMALLGLQRCHSAPPQGSLGDKPPWTQLRRAYGCGSMSGAICASRVKLQHLPSQEQWDRLLVLYPASLAIFSEEPEGLSFKGELPLSAIHINLEEKEKEIRSFLIEGHLINTIRVVCASYEDYSQWLLCLRTVSRRDGAHLPPGPESFPGLQKPTQLVGRGRGSLSSNGRSSWKLECPVFPTSQSLPESSVPTTIGFPAPPVPNQTDSNCVSTGQKKMKPSDSSPSPRGRAQREVSGSTVPLPLPLDLTKMSALNLDSGPEAQDHSLDIPHSPLYADPYTPPATSRHKITDIQGLDEFLCAIQTSPGPDLSSPFPPVSVSVPVSESSSGISSSPGPLGSHLLTKKGALQPRASQRHRGSFKSRGPQPSDFPQLVTPAREGKPSSLPPPPDEEAPIWNKTSSPSHPKWPQPRKPAVEGGFIQWI
uniprot
proteins
function
FUNCTION: Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1. Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (PubMed:27616329). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS) (By similarity). {ECO:0000250|UniProtKB:Q494U1, ECO:0000269|PubMed:27616329}.
uniprot
proteins
mass_dalton
66826
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is essential for its mitochondrial localization and regulates its interaction with C1QBP. {ECO:0000250|UniProtKB:Q494U1}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27616329
uniprot
proteins
sequence_length
610
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q494U1}; Lipid-anchor {ECO:0000250|UniProtKB:Q494U1}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q494U1}. Mitochondrion {ECO:0000269|PubMed:27616329}. Note=Interaction with C1QBP and phosphorylation is essential for its mitochondrial localization. Localizes on the microtubule in the form of small granules. {ECO:0000250|UniProtKB:Q494U1}.
uniprot
proteins