ACP6
entrez
51205
canonical
uniprot
Q9NPH0
canonical
ensembl
ENSG00000162836
resolver
ensp
ENSP00000463574
resolver
ensp
ENSP00000677739
resolver
ensp
ENSP00000718752
resolver
genesymbol
ACP6
resolver
genesymbol_syn
ACPL1
resolver
genesymbol_syn
LPAP
resolver
hgnc
HGNC:29609
resolver
uniprot
Q59G61
resolver
uniprot
Q5T490
resolver
uniprot
Q6IAQ3
resolver
uniprot
Q7LG81
resolver
uniprot
Q9UIG6
resolver
uniprot
X5D289
resolver
uniprot_entry
PPA6_HUMAN
resolver
uniprot_sec
Q59G61
resolver
uniprot_sec
Q5T490
resolver
uniprot_sec
Q6IAQ3
resolver
uniprot_sec
Q7LG81
resolver
uniprot_sec
Q9UIG6
resolver
uniprot_sec
X5D289
resolver
amino_acid_sequence
MITGVFSMRLWTPVGVLTSLAYCLHQRRVALAELQEADGQCPVDRSLLKLKMVQVVFRHGARSPLKPLPLEEQVEWNPQLLEVPPQTQFDYTVTNLAGGPKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQRAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAMDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQVPRGCPDGLCPLDMFLNAMSVYTLSPEKYHALCSQTQVMEVGNEE
uniprot
proteins
ec_number
3.1.3.106
uniprot
proteins
function
FUNCTION: Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. {ECO:0000269|PubMed:10506173, ECO:0000269|PubMed:23807634}.
uniprot
proteins
mass_dalton
48886
uniprot
proteins
mutagenesis
MUTAGEN 58; /note="R->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:23807634"; MUTAGEN 59; /note="H->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:10506173, ECO:0000269|PubMed:23807634"; MUTAGEN 62; /note="R->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:23807634"; MUTAGEN 106; /note="Y->F: Decreases enzyme activity."; /evidence="ECO:0000269|PubMed:23807634"; MUTAGEN 110; /note="Y->F: Decreases enzyme activity."; MUTAGEN 168; /note="R->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:23807634"; MUTAGEN 257; /note="A->F,L: Decreases enzyme activity by interfering with water access to the active site cavity."; /evidence="ECO:0000269|PubMed:23807634"; MUTAGEN 257; /note="A->W: Abolishes enzyme activity by interfering with water access to the active site cavity."; /evidence="ECO:0000269|PubMed:23807634"; MUTAGEN 285; /note="S->W: Decreases activity toward substrates with medium and long aliphatic chains, but not toward substrates with short aliphatic chains."; /evidence="ECO:0000269|PubMed:23807634"; MUTAGEN 289; /note="L->W: Decreases activity toward substrates with medium and long aliphatic chains, but not toward substrates with short aliphatic chains."; /evidence="ECO:0000269|PubMed:23807634"; MUTAGEN 334; /note="H->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:23807634"; MUTAGEN 335; /note="D->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:23807634
uniprot
proteins
protein_family
Histidine acid phosphatase family
uniprot
proteins
pubmed
10506173
uniprot
proteins
pubmed
12010880
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
23807634
uniprot
proteins
pubmed
24722188
uniprot
proteins
sequence_length
428
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10506173}.
uniprot
proteins