Cpne2
entrez
234577
canonical
uniprot
P59108
canonical
ensembl
ENSMUSG00000034361
resolver
ensp
ENSMUSP00000045755
resolver
ensp
ENSMUSP00000292958
resolver
enst
ENSMUST00000048653
resolver
genesymbol
Cpne2
resolver
uniprot
Q8K1D7
resolver
uniprot_entry
CPNE2_MOUSE
resolver
uniprot_sec
Q8K1D7
resolver
amino_acid_sequence
MAYIPDGGAPTAGAIPLGSQCCVCKVELSVSGQNLLDRDVTSKSDPFCVLFIEDNGRWMEFDRTETAVNNLNPAFSKKFVLDYHFEEVQKLKFALFDQDKSSAQLDEHDFLGQFSCSLGTIVSSKKITRPLLLMNDKPAGKGVITIAAQELSDNRVITLSLAGRKLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDLEKPIQVMCYDYDSNGGHDFIGEFQTSVLQMSEARDGVPLEIECINPKKQRKKKSYKNSGIIILRSCKIHRNYSFLDYILGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQQTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDNRRLRSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNLPPTNSEPA
uniprot
proteins
function
FUNCTION: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties (PubMed:21087455, PubMed:26175110). {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:26175110}.
uniprot
proteins
mass_dalton
61036
uniprot
proteins
mutagenesis
MUTAGEN 37; /note="D->N: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with N-39; N-97 and N-99."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 39; /note="D->N: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with N-37; N-97 and N-99."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 97; /note="D->N: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with N-37; N-39 and N-99."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 99; /note="D->N: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with N-37; N-39 and N-97."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 170; /note="D->N: Leads to a reduction in the amount of calcium-dependent translocation to the cell membrane. Leads to the constitutive (calcium-independent) attachment to the cell membrane; when associated with N-176; N-232 and N-234."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 176; /note="D->N: Does not inhibit calcium-dependent translocation to the cell membrane. Leads to the constitutive (calcium-independent) attachment to the cell membrane; when associated with N-170; N-232 and N-234."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 232; /note="D->N: Leads to a reduction in the amount of calcium-dependent translocation to the cell membrane. Leads to the constitutive (calcium-independent) attachment to the cell membrane; when associated with N-170; N-176 and N-234."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 234; /note="D->N: Leads to a reduction in the amount of calcium-dependent translocation to the cell membrane. Leads to the constitutive (calcium-independent) attachment to the cell membrane; when associated with N-170; N-176 and N-232."; /evidence="ECO:0000269|PubMed:26175110
uniprot
proteins
protein_family
Copine family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21087455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26175110
uniprot
proteins
sequence_length
548
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:26175110}. Nucleus {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:26175110}. Cell membrane {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:26175110}. Note=Translocates to the cell membrane and the nucleus in a calcium-dependent manner (PubMed:21087455, PubMed:26175110). Colocalizes with CD2 at the cell membrane (PubMed:21087455). {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:26175110}.
uniprot
proteins