Tfip11
entrez
54723
canonical
uniprot
Q9ERA6
canonical
ensembl
ENSMUSG00000029345
resolver
ensp
ENSMUSP00000031288
resolver
enst
ENSMUST00000031288
resolver
genesymbol
Tfip11
resolver
genesymbol_syn
Stip
resolver
genesymbol_syn
Tip39
resolver
uniprot
Q3TTV6
resolver
uniprot
Q8VD06
resolver
uniprot_entry
Q3TTV6_MOUSE
resolver
uniprot_entry
TFP11_MOUSE
resolver
uniprot_sec
Q8VD06
resolver
amino_acid_sequence
MSLSHLYRDGEGHLDDDDDDERENFEITDWDLQNEFNPNRQRHWQTKEEATYGVWAERDSDEERPSFGGKRARDYSAPVNFISAGLKKGAAEEADSEDSDAEEKPVKQEDFPKDLGPKKLKTGGNFKPSQKGFSGGTKSFMDFGSWERHTKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAYGSERTTQSLQDFPVADSEEEAEEEFQKELSQWRKDPSGSKKKPKYSYKTVEELKAKGRVSKKLTAPQKELSQVKVIDMTGREQKVYYSYSQISHKHSVPDEGVPLLAQLPPTAGKEARMPGFALPELEHNLQLLIERTEQEIIQSDRQLQYERDMVVSLSHELEKTAEVLAHEERVISNLSKVLALVEECERRMQPHGADPLTLDECARIFETLQDKYYEEYRLADRADLAVAIVYPLVKDYFKDWHPLEDGSYGTQIISKWKSLLENDQLLSHSSQDLSSDAFHRLMWEVWMPFVRNVVAQWQPRNCEPMVDFLDSWAHIIPVWILDNILDQLIFPKLQKEVDNWNPLTDTVPIHSWIHPWLPLMQARLEPLYSPVRSKLSSALQKWHPSDASAKLILQPWKEVLTPGSWEAFMLRNIVPKLGMCLGELVINPHQQHMDAFYWVMDWEGMISVSSLVGLLEKHFFPKWLQVLCSWLSNSPNYEEITKWYLGWKSMFSDQVLAHPSVKDKFNEALDIMNRAVSSNVGAYMQPGARENIAYLTHTERRKDFQYEAMQERREAENMAQRGIGVAASSVPMNFKDLIETKAEEHNIVFMPVIGKRHEGKQLYTFGRIVIYIDRGVVFVQGEKTWVPTSLQSLIDMAK
uniprot
proteins
function
FUNCTION: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. {ECO:0000269|PubMed:15868102, ECO:0000269|PubMed:19857462}.
uniprot
proteins
mass_dalton
96305
uniprot
proteins
mutagenesis
MUTAGEN 166; /note="G->A: No effect on nuclear speckled pattern localization; when associated with A-168 and R-170."; /evidence="ECO:0000269|PubMed:19165350"; MUTAGEN 168; /note="G->A: No effect on nuclear speckled pattern localization; when associated with A-166 and R-170."; /evidence="ECO:0000269|PubMed:19165350"; MUTAGEN 170; /note="G->R: No effect on nuclear speckled pattern localization; when associated with A-166 and A-168."; /evidence="ECO:0000269|PubMed:19165350"; MUTAGEN 701..706; /note="VKDKFN->TTTTT: Predominant cytoplasmic localization."; /evidence="ECO:0000269|PubMed:19857462
uniprot
proteins
protein_family
TFP11/STIP family
uniprot
proteins
pubmed
10806191
uniprot
proteins
pubmed
11063033
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15868102
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19165350
uniprot
proteins
pubmed
19857462
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
838
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles.
uniprot
proteins