Triap1
entrez
69076
canonical
uniprot
Q9D8Z2
canonical
ensembl
ENSMUSG00000029535
resolver
ensp
ENSMUSP00000031508
resolver
enst
ENSMUST00000031508
resolver
genesymbol
Triap1
resolver
genesymbol_syn
15e1.1
resolver
uniprot
Q6LCG5
resolver
uniprot_entry
TRIA1_MOUSE
resolver
uniprot_sec
Q6LCG5
resolver
amino_acid_sequence
MNSVGEACTDMKREYDQCFNRWFAEKFLKGDGSGDPCTDLFKRYQQCVQKAIKEKEIPIEGLEFMGHGKEKPENSS
uniprot
proteins
function
FUNCTION: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. {ECO:0000250|UniProtKB:O43715}.
uniprot
proteins
mass_dalton
8756
uniprot
proteins
protein_family
TRIAP1/MDM35 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
76
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:O43715}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:O43715}.
uniprot
proteins