Porcn
entrez
53627
canonical
uniprot
Q9JJJ7
canonical
ensembl
ENSMUSG00000031169
resolver
ensp
ENSMUSP00000076790
resolver
ensp
ENSMUSP00000080937
resolver
ensp
ENSMUSP00000086824
resolver
ensp
ENSMUSP00000086825
resolver
ensp
ENSMUSP00000232440
resolver
ensp
ENSMUSP00000232442
resolver
ensp
ENSMUSP00000232445
resolver
ensp
ENSMUSP00000232451
resolver
genesymbol
Porcn
resolver
genesymbol_syn
Porc
resolver
genesymbol_syn
Ppn
resolver
uniprot
A2AC30
resolver
uniprot
A2AC32
resolver
uniprot
A2AC33
resolver
uniprot
Q9CWT0
resolver
uniprot
Q9JJJ8
resolver
uniprot
Q9JJJ9
resolver
uniprot
Q9JJK0
resolver
uniprot_entry
PORCN_MOUSE
resolver
uniprot_sec
A2AC30
resolver
uniprot_sec
A2AC32
resolver
uniprot_sec
A2AC33
resolver
uniprot_sec
Q9CWT0
resolver
uniprot_sec
Q9JJJ8
resolver
uniprot_sec
Q9JJJ9
resolver
uniprot_sec
Q9JJK0
resolver
amino_acid_sequence
MATFSRQEFFQQLLQGCLLPTVQQGLDQIWLLLTICFACRLLWRLGLPSYLKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGAVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSRRWLKKVARSLALALLCLVLSTCVGPYLFPYFIPLDGDRLLRNKKRKARGTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSRPLNVELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLAQILSACILSKRCLPDCSHRHRLGLGVRALNLLFGALAIFHLSYLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
uniprot
proteins
ec_number
2.3.1.250
uniprot
proteins
function
FUNCTION: Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. {ECO:0000269|PubMed:10866835, ECO:0000269|PubMed:17141155, ECO:0000269|PubMed:22046319, ECO:0000269|PubMed:24055053, ECO:0000269|PubMed:24798332}.
uniprot
proteins
mass_dalton
52508
uniprot
proteins
mutagenesis
MUTAGEN 136; /note="S->F: Impaired acyltransferase activity."; /evidence="ECO:0000269|PubMed:24798332"; MUTAGEN 172; /note="S->A: Does not affect acyltransferase activity."; /evidence="ECO:0000269|PubMed:24798332"; MUTAGEN 228; /note="R->C: Does not affect acyltransferase activity."; /evidence="ECO:0000269|PubMed:24798332"; MUTAGEN 305; /note="W->A: Impaired acyltransferase activity."; /evidence="ECO:0000269|PubMed:24798332"; MUTAGEN 306; /note="N->A: Does not affect acyltransferase activity."; /evidence="ECO:0000269|PubMed:24798332"; MUTAGEN 312; /note="W->A: Does not affect acyltransferase activity."; /evidence="ECO:0000269|PubMed:24798332"; MUTAGEN 316; /note="Y->A: Impaired acyltransferase activity."; /evidence="ECO:0000269|PubMed:24798332"; MUTAGEN 331; /note="L->R: Impaired acyltransferase activity."; /evidence="ECO:0000269|PubMed:24798332"; MUTAGEN 334; /note="Y->A: Impaired acyltransferase activity. Impaired ability to interact with WNT3A."; /evidence="ECO:0000269|PubMed:24798332"; MUTAGEN 337; /note="S->A: Abolished acyltransferase activity. Impaired ability to interact with WNT3A."; /evidence="ECO:0000269|PubMed:24798332"; MUTAGEN 340; /note="L->A: Abolished acyltransferase activity."; /evidence="ECO:0000269|PubMed:24798332"; MUTAGEN 341; /note="H->A: Abolished acyltransferase activity. Impaired ability to interact with WNT3A."; /evidence="ECO:0000269|PubMed:24798332"; MUTAGEN 365; /note="R->Q: Impaired acyltransferase activity."; /evidence="ECO:0000269|PubMed:24798332
uniprot
proteins
protein_family
Membrane-bound acyltransferase family
uniprot
proteins
protein_family
Porcupine subfamily
uniprot
proteins
pubmed
10866835
uniprot
proteins
pubmed
12842094
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17141155
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22046319
uniprot
proteins
pubmed
24055053
uniprot
proteins
pubmed
24798332
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10866835, ECO:0000269|PubMed:24798332}; Multi-pass membrane protein {ECO:0000269|PubMed:10866835}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 67..87; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 96..116; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 153..173; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 199..219; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 253..273; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 338..358; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 397..417; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins