INPP5B
entrez
3633
canonical
uniprot
P32019
canonical
ensembl
ENSG00000204084
resolver
ensp
ENSP00000362115
resolver
ensp
ENSP00000362118
resolver
ensp
ENSP00000545106
resolver
ensp
ENSP00000618309
resolver
genesymbol
INPP5B
resolver
genesymbol_syn
OCRL2
resolver
hgnc
HGNC:6077
resolver
uniprot
B3KMW4
resolver
uniprot
C9J6U5
resolver
uniprot
Q5VSG9
resolver
uniprot
Q5VSH0
resolver
uniprot
Q5VSH1
resolver
uniprot
Q658Q5
resolver
uniprot
Q6P6D4
resolver
uniprot
Q6PD53
resolver
uniprot
Q86YE1
resolver
uniprot_entry
B3KMW4_HUMAN
resolver
uniprot_entry
I5P2_HUMAN
resolver
uniprot_sec
C9J6U5
resolver
uniprot_sec
Q5VSG9
resolver
uniprot_sec
Q5VSH0
resolver
uniprot_sec
Q5VSH1
resolver
uniprot_sec
Q658Q5
resolver
uniprot_sec
Q6P6D4
resolver
uniprot_sec
Q6PD53
resolver
uniprot_sec
Q86YE1
resolver
amino_acid_sequence
MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRMAITGDDVSLDQIVPVSRDFTLEEVSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRMFLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGRYPSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEEAGREMSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVRSLDKMENANIPSVSLSKREFCFQNVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLNANPSRGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYLPSCFGSPIHTLCYMREPILDLPLETISELTLMPVWTGDDGSQLDSPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICYSTYHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFGSLLLRNPAGHQKLDMTEKKKAQEFIHQFLCNPL
uniprot
proteins
ec_number
3.1.3.36
uniprot
proteins
ec_number
3.1.3.56
uniprot
proteins
function
FUNCTION: Regulates phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) cellular levels by cleaving the phosphate at the 5-position producing PtdIns(4)P. Also hydrolyzes the 5-position phosphate from inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), thereby modulating cellular signaling events. {ECO:0000269|PubMed:7721860}.
uniprot
proteins
mass_dalton
112852
uniprot
proteins
mutagenesis
MUTAGEN 990; /note="C->S: Loss of prenylation and membrane localization; when tested in a heterologous system. Does not affect catalytic activity toward Ins(1,4,5)P3."; /evidence="ECO:0000269|PubMed:7721860
uniprot
proteins
post_translational_modification
PTM: Isoprenylation at Cys-990 may be required for localization at the membrane. {ECO:0000269|PubMed:7721860}.; PTM: May be proteolytically cleaved after Lys-320 as inferred from N-terminal protein sequence of the 75 kda form. {ECO:0000269|PubMed:1718960}.
uniprot
proteins
protein_family
4
uniprot
proteins
protein_family
5-trisphosphate 5-phosphatase type II family
uniprot
proteins
protein_family
Inositol 1
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1718960
uniprot
proteins
pubmed
17956944
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20133602
uniprot
proteins
pubmed
21233288
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25869668
uniprot
proteins
pubmed
26824392
uniprot
proteins
pubmed
7721860
uniprot
proteins
sequence_length
993
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:7721860}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:17956944}. Early endosome membrane {ECO:0000269|PubMed:17956944}. Membrane {ECO:0000269|PubMed:7721860}; Peripheral membrane protein {ECO:0000305|PubMed:7721860}; Cytoplasmic side {ECO:0000305|PubMed:7721860}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q8K337}. Golgi apparatus {ECO:0000269|PubMed:17956944}.
uniprot
proteins