FAM120A
entrez
218236
canonical
uniprot
Q6A0A9
canonical
ensembl
ENSMUSG00000038014
resolver
ensp
ENSMUSP00000053877
resolver
enst
ENSMUST00000060805
resolver
genesymbol
FAM120A
resolver
genesymbol_syn
Kiaa0183
resolver
genesymbol_syn
Ossa
resolver
uniprot
A0PJK6
resolver
uniprot
B3DFJ0
resolver
uniprot
Q91Z16
resolver
uniprot_entry
F120A_MOUSE
resolver
uniprot_sec
A0PJK6
resolver
uniprot_sec
B3DFJ0
resolver
uniprot_sec
Q91Z16
resolver
amino_acid_sequence
MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGGFYTDWVSGGQWNHMLGYLAALAKACFGGNIELFVFFNGALEKARLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFHGLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVADYVRNIHDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAVGYYSATSKPMPFHPPHYLARPNPFGMPGMVPPYVPPQMLNIPQTSLQAKPAVPQVPSPGGTPGQAPYPYSLSEPALTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINLAQSGSPNHVDSAYFPGSSTSSSSDNDEGGGGATNHISGNKIGWEKTGSHAEPLARGDPGDQVKVEGSSTASSGSQLAEGKGSHMGTVQPIPCLLSMPTRNHMDITTPPLPPVAPEVLRVAEHRHKKGLMYPYIFHILTKGEIKIAVSIEDEANKDLPPAALLYRPVRQYVYGVLFSLAESRKKTERLAFRKNRLPPEFSPLIIKEWAAYKGKSPQTPELVEALAFREWTCPNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNPANVPTHLMVLCCVLRYMVQWPGARILRRQELDAFLAQALSPKLYEPDQLQELKIDNLDPRGIQLSALFMSGVDMALFANDACGQPIPWEHCCPWMYFDGKLFQSKLLKASREKTPLIDLCDGQAEQAAKVEKMRQSILEGLSFSRQNHPLPFPPPPALPFYPASVYPRHFGPVPPSQGRGRGFAGVCGFGGHYGETVATGPYRAFRVTAASGHCGAFSGSDSSRTSKSQGGVQPIPSQGGKLEIAGTVVGHWAGSRRGRGGRGPFPLQVVSVGGPARGRPRGVISTPVIRTFGRGGRYYGRGYKSQGAIQGRPPYAASAEEVAKELKSKSGESKSSAVSLAENGVMAEEKPVPQLNGSTGDPRVPSHSESALNNDSKPCNTNPHLNALSTDSACRREAALEAAVLNKEE
uniprot
proteins
function
FUNCTION: Membrane-associated scaffold protein that participates in multiple cellular processes, including oxidative stress-induced survival signaling, RNA trafficking and translational regulation, and the modulation of membrane signaling through its interaction with RNA-binding proteins and lipid raft-associated domains. Functions as a regulator of activation of several intracellular kinases, including SRC, FAK, and PI3K, following oxidative stress. Promotes RNA splicing and stability of lipogenic enzymes. Mechanistically, recruits the lipogenic transcription factor SREBP1 at active promoters, thereby bridging the newly transcribed lipogenic genes from RNA polymerase II to the SRSF1 and U1-70K-containing RNA-splicing machinery. Associates with key proteins of the NLRP3 inflammasome pathway and subsequently inhibits NLRP3 inflammasome activation (By similarity). Sequesters a subset of AGO2-bound mRNAs from miRNA-mediated silencing by binding to poly(G)-rich motifs in their 3'-UTR independently of the AGO2 binding site, likely by preventing recruitment of miRISC effectors (PubMed:31289130). {ECO:0000250|UniProtKB:Q9NZB2, ECO:0000269|PubMed:31289130}.
uniprot
proteins
mass_dalton
121646
uniprot
proteins
post_translational_modification
PTM: Arg-980 is dimethylated, probably to asymmetric dimethylarginine. {ECO:0000250|UniProtKB:Q9NZB2}.; PTM: Phosphorylated on tyrosine by src family kinases upon ultraviolet exposure. {ECO:0000250|UniProtKB:Q9NZB2}.
uniprot
proteins
protein_family
Constitutive coactivator of PPAR-gamma family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18413649
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
31289130
uniprot
proteins
sequence_length
1112
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NZB2}. Cell membrane {ECO:0000250|UniProtKB:Q9NZB2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NZB2}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9NZB2}. Note=Translocates from the cytosol to plasma membrane after UV irradiation. {ECO:0000250|UniProtKB:Q9NZB2}.
uniprot
proteins