Smad1
entrez
25671
canonical
uniprot
P97588
canonical
ensembl
ENSRNOG00000018483
resolver
ensp
ENSRNOP00000025079
resolver
ensp
ENSRNOP00000102689
resolver
enst
ENSRNOT00000025079
resolver
enst
ENSRNOT00000136882
resolver
genesymbol
Smad1
resolver
genesymbol_syn
Mad1
resolver
genesymbol_syn
Madh1
resolver
uniprot
A0A0G2JSQ6
resolver
uniprot
A0ABK0L233
resolver
uniprot
O70520
resolver
uniprot
Q6P7A6
resolver
uniprot_entry
A0A0G2JSQ6_RAT
resolver
uniprot_entry
A0ABK0L233_RAT
resolver
uniprot_entry
Q6P7A6_RAT
resolver
uniprot_entry
SMAD1_RAT
resolver
uniprot_sec
O70520
resolver
amino_acid_sequence
MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPHSHPFAQYPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMAQDGSQPMDTNMTNMTAPTLPAEINRGDVQAVAYEEPKHWCSIVYYELNNRVGERFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETEYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
uniprot
proteins
function
FUNCTION: Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis. Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form an heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000250|UniProtKB:Q15797}.
uniprot
proteins
mass_dalton
52713
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of the C-terminal SVS motif by BMP type 1 receptor kinase activates SMAD1 by promoting dissociation from the receptor and trimerization with SMAD4. Phosphorylation by ERK2 MAP kinase in response to EGF or HGF prevents SMAD1 nuclear accumulation and transcriptional activity in response to BMP (By similarity). Dephosphorylation, probably by PPM1A, induces its export from the nucleus to the cytoplasm (By similarity). Dephosphorylation is inhibited by association with EGR1 (By similarity). Phosphorylation by CDK8/9 creates binding sites for YAP1, and subsequent phosphorylation by GSK3 switches off YAP1 binding and adds binding sites for SMURF1 (By similarity). {ECO:0000250|UniProtKB:Q15797}.; PTM: Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading to its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes. Dephosphorylation, probably by PPM1A, induces its export from the nucleus to the cytoplasm (By similarity). Phospho-SMAD1 is ubiquitinated by CHIP leading to disruption of the SMAD1-SMAD4 complex (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000250|UniProtKB:Q15797}.
uniprot
proteins
protein_family
Dwarfin/SMAD family
uniprot
proteins
pubmed
8917532
uniprot
proteins
pubmed
9989785
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15797}. Nucleus {ECO:0000250|UniProtKB:Q15797}. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane (By similarity). Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000250|UniProtKB:Q15797}.
uniprot
proteins