Sgms1
entrez
208449
canonical
uniprot
Q8VCQ6
canonical
ensembl
ENSMUSG00000040451
resolver
ensp
ENSMUSP00000097114
resolver
ensp
ENSMUSP00000117336
resolver
ensp
ENSMUSP00000123395
resolver
ensp
ENSMUSP00000313767
resolver
ensp
ENSMUSP00000313771
resolver
ensp
ENSMUSP00000313774
resolver
ensp
ENSMUSP00000313783
resolver
ensp
ENSMUSP00000313788
resolver
ensp
ENSMUSP00000313801
resolver
ensp
ENSMUSP00000340081
resolver
ensp
ENSMUSP00000349492
resolver
ensp
ENSMUSP00000349495
resolver
ensp
ENSMUSP00000362155
resolver
ensp
ENSMUSP00000362158
resolver
genesymbol
Sgms1
resolver
genesymbol_syn
Tmem23
resolver
uniprot
Q3UIS8
resolver
uniprot
Q5J3R0
resolver
uniprot
Q8C464
resolver
uniprot
Q8C583
resolver
uniprot
Q8C652
resolver
uniprot_entry
SMS1_MOUSE
resolver
uniprot_sec
Q3UIS8
resolver
uniprot_sec
Q5J3R0
resolver
uniprot_sec
Q8C464
resolver
uniprot_sec
Q8C583
resolver
uniprot_sec
Q8C652
resolver
amino_acid_sequence
MLSARTMKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLYRVSSDNGQRLLDMIETLKMEHHMEAHKNGHANGHLSIGVDIPNPDGSFSIKTKPNGMPNGFRKEMIKIPMPEPERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLFQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQVRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT
uniprot
proteins
ec_number
2.7.8.27
uniprot
proteins
function
FUNCTION: Major sphingomyelin synthase at the Golgi apparatus. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes. Converts the newly synthesized CER, that is transported from the endoplasmic reticulum to the trans-Golgi by the Cer transport protein (CERT), to SM. Can form a heteromeric complex with glucosylceramide synthase (GCS) increasing SMS activity and reducing glucosylceramide synthesis, a critical mechanism that controls the metabolic fate of CER in the Golgi (By similarity). Does not use free phosphorylcholine or CDP-choline as donor. Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to CER to form ceramide phosphoethanolamine (CPE) (PubMed:25605874). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (PubMed:16879426, PubMed:22580896). Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (By similarity). {ECO:0000250|UniProtKB:Q86VZ5, ECO:0000269|PubMed:16879426, ECO:0000269|PubMed:22580896, ECO:0000269|PubMed:25605874}.; FUNCTION: (Microbial infection) Contributes to the brain SM production for Japanese encephalitis virus attachment and infection. {ECO:0000269|PubMed:27892528}.
uniprot
proteins
mass_dalton
49317
uniprot
proteins
pathway_participation
PATHWAY: Sphingolipid metabolism. {ECO:0000269|PubMed:27892528}.
uniprot
proteins
protein_family
Sphingomyelin synthase family
uniprot
proteins
pubmed
14685263
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16226406
uniprot
proteins
pubmed
16879426
uniprot
proteins
pubmed
22580896
uniprot
proteins
pubmed
22641779
uniprot
proteins
pubmed
25605874
uniprot
proteins
pubmed
27892528
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q86VZ5}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 221..241; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 282..302; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 310..330; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 336..353; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins