Rab25
entrez
53868
canonical
uniprot
Q9WTL2
canonical
ensembl
ENSMUSG00000008601
resolver
ensp
ENSMUSP00000008745
resolver
ensp
ENSMUSP00000120505
resolver
enst
ENSMUST00000008745
resolver
genesymbol
Rab25
resolver
uniprot
Q0PD30
resolver
uniprot
Q9D1P3
resolver
uniprot_entry
Q0PD30_MOUSE
resolver
uniprot_entry
RAB25_MOUSE
resolver
uniprot_sec
Q9D1P3
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation. {ECO:0000250|UniProtKB:P57735}.
uniprot
proteins
amino_acid_sequence
MGNRTDEDYNFVFKVVLIGESGVGKTNLLSRFTRNEFSHDSRTTIGVEFSTRTVMLGTAAVKAQIWDTAGLERYRAITSAYYRGAVGALLVFDLTKHQTYAVVERWLKELYDHAEATIVVMLVGNKSDLSQAREVPTEEACMFAENNGLLFLETSALDSTNVELAFQTVLKEIFAKVSKQKQNSTRTSAITLGNAQAGQDPGPGEKRACCISL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB25 regulates epithelial cell differentiation, proliferation and survival, thereby playing key roles in tumorigenesis. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (By similarity). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (PubMed:22696678). May selectively regulate the apical recycling pathway (By similarity). Together with MYO5B regulates transcytosis (By similarity). {ECO:0000250|UniProtKB:E2RQ15, ECO:0000250|UniProtKB:P46629, ECO:0000250|UniProtKB:P57735, ECO:0000250|UniProtKB:P61106, ECO:0000269|PubMed:22696678}.
uniprot
proteins
mass_dalton
23473
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10708602
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22696678
uniprot
proteins
sequence_length
213
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, pseudopodium membrane {ECO:0000250|UniProtKB:P57735}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P57735}. Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips. Colocalizes with RAB11A in subapical vesicles (By similarity). {ECO:0000250|UniProtKB:P46629, ECO:0000250|UniProtKB:P57735}.
uniprot
proteins