Hpgds
entrez
58962
canonical
uniprot
O35543
canonical
ensembl
ENSRNOG00000006583
resolver
ensembl
ENSRNOG00055014398
resolver
ensembl
ENSRNOG00060021729
resolver
ensembl
ENSRNOG00065029784
resolver
ensp
ENSRNOP00000008826
resolver
ensp
ENSRNOP00000106939
resolver
ensp
ENSRNOP00055020197
resolver
ensp
ENSRNOP00060031027
resolver
ensp
ENSRNOP00065042379
resolver
enst
ENSRNOT00000123843
resolver
enst
ENSRNOT00055024716
resolver
enst
ENSRNOT00060037634
resolver
enst
ENSRNOT00065051465
resolver
genesymbol
Hpgds
resolver
genesymbol_syn
Gsts
resolver
genesymbol_syn
Pgds
resolver
genesymbol_syn
Ptgds2
resolver
uniprot
A0ABK0LT11
resolver
uniprot
O35351
resolver
uniprot_entry
A0ABK0LT11_RAT
resolver
uniprot_entry
HPGDS_RAT
resolver
uniprot_sec
O35351
resolver
amino_acid_sequence
MPNYKLLYFNMRGRAEIIRYIFAYLDIKYEDHRIEQADWPKIKPTLPFGKIPVLEVEGLTLHQSLAIARYLTKNTDLAGKTELEQCQVDAVVDTLDDFMSLFPWAEENQDLKERTFNDLLTRQAPHLLKDLDTYLGDKEWFIGNYVTWADFYWDICSTTLLVLKPDLLGIYPRLVSLRNKVQAIPAISAWILKRPQTKL
uniprot
proteins
ec_number
2.5.1.18
uniprot
proteins
ec_number
5.3.99.2
uniprot
proteins
function
FUNCTION: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates (PubMed:10871602, PubMed:11672424, PubMed:16547010, PubMed:9323136). Similarly, catalyzes the conversion of PGH3 (derived from eicosapentaenoate (EPA, C20:5n-3)) to PGD3, though PGH2 remains the preferred substrate. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide (By similarity). {ECO:0000250|UniProtKB:O60760, ECO:0000269|PubMed:10871602, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:9323136}.
uniprot
proteins
mass_dalton
23297
uniprot
proteins
mutagenesis
MUTAGEN 8; /note="Y->F: Moderate reduction of protein expression levels. Abolishes both prostaglandin D synthase and glutathione-conjugating activities."; /evidence="ECO:0000269|PubMed:10871602"; MUTAGEN 14; /note="R->E: Moderate reduction of protein expression levels. Abolishes both prostaglandin D synthase and glutathione-conjugating activities."; /evidence="ECO:0000269|PubMed:10871602"; MUTAGEN 14; /note="R->K: Moderate reduction of protein expression levels. Abolishes both prostaglandin D synthase and glutathione-conjugating activities."; /evidence="ECO:0000269|PubMed:10871602"; MUTAGEN 104; /note="W->I: No significant effect on protein expression levels. Abolishes both prostaglandin D synthase and glutathione-conjugating activities."; /evidence="ECO:0000269|PubMed:10871602"; MUTAGEN 112; /note="K->E: Significant reduction of protein expression levels. Significantly reduces prostaglandin D synthase and moderately reduces glutathione-conjugating activities."; /evidence="ECO:0000269|PubMed:10871602"; MUTAGEN 152; /note="Y->F: Significant reduction of protein expression levels. Moderately reduces prostaglandin D synthase activity."; /evidence="ECO:0000269|PubMed:10871602"; MUTAGEN 156; /note="C->L: No significant effect on protein expression levels. Abolishes prostaglandin D synthase and significantly reduces glutathione-conjugating activities."; /evidence="ECO:0000269|PubMed:10871602"; MUTAGEN 156; /note="C->Y: Significant reduction of protein expression levels. Abolishes prostaglandin D synthase and significantly reduces glutathione-conjugating activities."; /evidence="ECO:0000269|PubMed:10871602"; MUTAGEN 198; /note="K->E: Moderate reduction of protein expression levels. No significant effect on catalytic activities."; /evidence="ECO:0000269|PubMed:10871602"; MUTAGEN 199; /note="L->F: Moderate reduction of protein expression levels. No significant effect on catalytic activities."; /evidence="ECO:0000269|PubMed:10871602
uniprot
proteins
protein_family
GST superfamily
uniprot
proteins
protein_family
Sigma family
uniprot
proteins
pubmed
10871602
uniprot
proteins
pubmed
11672424
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16547010
uniprot
proteins
pubmed
9323136
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins