PDXP
entrez
57026
canonical
uniprot
Q96GD0
canonical
ensembl
ENSG00000241360
resolver
ensp
ENSP00000215904
resolver
enst
ENST00000215904
resolver
genesymbol
PDXP
resolver
genesymbol_syn
CIN
resolver
genesymbol_syn
PLP
resolver
genesymbol_syn
PLPP
resolver
hgnc
HGNC:30259
resolver
uniprot
A0A024R1I3
resolver
uniprot
Q9UGY2
resolver
uniprot_entry
A0A024R1I3_HUMAN
resolver
uniprot_entry
PLPP_HUMAN
resolver
uniprot_sec
Q9UGY2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by NaF, Zn(2+), Ca(2+), Mn(2+) and EDTA. {ECO:0000269|PubMed:15580268}.
uniprot
proteins
amino_acid_sequence
MARCERLRGAALRDVLGRAQGVLFDCDGVLWNGERAVPGAPELLERLARAGKAALFVSNNSRRARPELALRFARLGFGGLRAEQLFSSALCAARLLRQRLPGPPDAPGAVFVLGGEGLRAELRAAGLRLAGDPSAGDGAAPRVRAVLVGYDEHFSFAKLREACAHLRDPECLLVATDRDPWHPLSDGSRTPGTGSLAAAVETASGRQALVVGKPSPYMFECITENFSIDPARTLMVGDRLETDILFGHRCGMTTVLTLTGVSRLEEAQAYLAAGQHDLVPHYYVESIADLTEGLED
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.74
uniprot
proteins
function
FUNCTION: Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism (PubMed:14522954, PubMed:8132548). Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine (PubMed:15580268). {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268, ECO:0000269|PubMed:8132548}.
uniprot
proteins
mass_dalton
31698
uniprot
proteins
mutagenesis
MUTAGEN 25; /note="D->N: Abolishes protein phosphatase activity."; /evidence="ECO:0000269|PubMed:15580268
uniprot
proteins
protein_family
HAD-like hydrolase superfamily
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14522954
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15580268
uniprot
proteins
pubmed
18058037
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23223568
uniprot
proteins
pubmed
8132548
uniprot
proteins
sequence_length
296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody. {ECO:0000269|PubMed:15580268}.
uniprot
proteins