MAP3K4
entrez
4216
canonical
uniprot
Q9Y6R4
canonical
ensembl
ENSG00000085511
resolver
ensp
ENSP00000297332
resolver
ensp
ENSP00000355886
resolver
ensp
ENSP00000355887
resolver
ensp
ENSP00000375986
resolver
ensp
ENSP00000545698
resolver
ensp
ENSP00000736277
resolver
enst
ENST00000348824
resolver
enst
ENST00000366920
resolver
genesymbol
MAP3K4
resolver
genesymbol_syn
KIAA0213
resolver
genesymbol_syn
MAPKKK4
resolver
genesymbol_syn
MEKK4
resolver
genesymbol_syn
MTK1
resolver
hgnc
HGNC:6856
resolver
uniprot
A6H8W0
resolver
uniprot
B7ZLD3
resolver
uniprot
B9EG75
resolver
uniprot
F5H538
resolver
uniprot
J3KNB8
resolver
uniprot
Q5VTT8
resolver
uniprot
Q5VTT9
resolver
uniprot
Q92612
resolver
uniprot
Q9H408
resolver
uniprot
Q9P1M2
resolver
uniprot_entry
F5H538_HUMAN
resolver
uniprot_entry
J3KNB8_HUMAN
resolver
uniprot_entry
M3K4_HUMAN
resolver
uniprot_entry
Q9P1M2_HUMAN
resolver
uniprot_sec
A6H8W0
resolver
uniprot_sec
B7ZLD3
resolver
uniprot_sec
B9EG75
resolver
uniprot_sec
Q5VTT8
resolver
uniprot_sec
Q5VTT9
resolver
uniprot_sec
Q92612
resolver
uniprot_sec
Q9H408
resolver
activity_regulation
ACTIVITY REGULATION: N-terminal autoinhibitory domain interacts with the C-terminal kinase domain, inhibiting kinase activity, and preventing interaction with its substrate, MAP2K6. The GADD45 proteins activate the kinase by binding to the N-terminal domain. Activated by phosphorylation on Thr-1505. {ECO:0000269|PubMed:12052864}.
uniprot
proteins
amino_acid_sequence
MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSACKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAPNQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILTFKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMELLEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDNSFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}.
uniprot
proteins
mass_dalton
181685
uniprot
proteins
mutagenesis
MUTAGEN 1372; /note="K->R: Loss of activity."; /evidence="ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
12052864
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15262978
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16157600
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20221403
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9039502
uniprot
proteins
pubmed
9305639
uniprot
proteins
sequence_length
1608
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles. {ECO:0000250}.
uniprot
proteins