P45380
uniprot
P45380
canonical
activity_regulation
ACTIVITY REGULATION: Inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS). {ECO:0000269|PubMed:3661708, ECO:0000269|PubMed:8300633}.
uniprot
proteins
amino_acid_sequence
MDASPEPPQKGGTLVLVRRQPPVSQGLLETLKARLKKSCTCSMPCAQALVQGLFPVIRWLPQYRLKEYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVNVGIFSLLCLMVGQVVDRELQLAGFDPSQDSLGPGNNDSTLNNTATLTVGLQDCGRDCHAIRIATALTLMAGLYQVLMGILRLGFVSTYLSQPLLDGFAMGASVTILTSQAKHLLGVRIPRHQGLGMVIHTWLSLLQNVGQANLCDVVTSAVCLAVLLTAKELSDRYRHYLKVPVPTELLVIVVATIASHFGQLHTRFGSSVAGNIPTGFVAPQIPDPKIMWSVALDAMSLALVGSAFSISLAEMFARSHGYSVSANQELLAVGCCNVLPAFFHCFATSAALSKTLVKIATGCQTQLSSVVSAAVVLLVLLVLAPLFHDLQRCVLACIIVVSLRGALRKVKDLPQLWRLSPADALVWVATAATCVLVSIEAGLLAGVFFSLLSLAGRTQRPRAALLARIGDSTFYEDAAEFEGLLPPPEVRVFRFTGPLYYANKDFFLRSLYSLTGLDAGYSATRKDRGTEVGVSNRSLVDRKDLGSVSSGDGLVVPLAFGFHTVVIDCAPLLFLDVAGMATLKDLRKNYRALDITLLLACCSPSVRDTLRKGGFLGEDQGTAEELLFPSVHSAVETACARREELMAADSAL
uniprot
proteins
function
FUNCTION: Sodium-independent sulfate anion transporter (PubMed:16357056, PubMed:19369292, PubMed:21093948, PubMed:3661708, PubMed:8300633, PubMed:9689008). Can transport other anions including thiosulfate, bicarbonate and oxalate by mediating sulfate-oxalate, sulfate-bicarbonate, sulfate-thiosulfate and oxalate-bicarbonate anion exchange (PubMed:16357056, PubMed:19369292, PubMed:21093948, PubMed:3661708, PubMed:8300633, PubMed:9689008). {ECO:0000269|PubMed:19369292, ECO:0000269|PubMed:21093948, ECO:0000269|PubMed:3661708, ECO:0000269|PubMed:8300633, ECO:0000269|PubMed:9689008}.
uniprot
proteins
mass_dalton
75447
uniprot
proteins
protein_family
SLC26A/SulP transporter (TC 2.A.53) family
uniprot
proteins
pubmed
16357056
uniprot
proteins
pubmed
19369292
uniprot
proteins
pubmed
21093948
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
27210743
uniprot
proteins
pubmed
3661708
uniprot
proteins
pubmed
8300633
uniprot
proteins
pubmed
9689008
uniprot
proteins
sequence_length
703
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P58735}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:16357056, ECO:0000269|PubMed:27210743, ECO:0000269|PubMed:9689008}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 68..90; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..116; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 184..206; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 260..279; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 291..313; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 346..368; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 381..403; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 416..438; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 476..498; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins