Mtdh
entrez
67154
canonical
uniprot
Q80WJ7
canonical
ensembl
ENSMUSG00000022255
resolver
ensp
ENSMUSP00000022865
resolver
ensp
ENSMUSP00000130190
resolver
ensp
ENSMUSP00000131814
resolver
ensp
ENSMUSP00000267833
resolver
ensp
ENSMUSP00000267834
resolver
ensp
ENSMUSP00000267835
resolver
ensp
ENSMUSP00000267836
resolver
ensp
ENSMUSP00000267839
resolver
ensp
ENSMUSP00000267840
resolver
ensp
ENSMUSP00000267842
resolver
ensp
ENSMUSP00000267850
resolver
enst
ENSMUST00000022865
resolver
genesymbol
Mtdh
resolver
genesymbol_syn
Lyric
resolver
uniprot
B2RSG8
resolver
uniprot
Q05CM0
resolver
uniprot
Q3U9F8
resolver
uniprot
Q3UAQ8
resolver
uniprot
Q8BN67
resolver
uniprot
Q8CBT9
resolver
uniprot
Q8CDL0
resolver
uniprot
Q8CGI7
resolver
uniprot
Q9D052
resolver
uniprot_entry
LYRIC_MOUSE
resolver
uniprot_sec
B2RSG8
resolver
uniprot_sec
Q05CM0
resolver
uniprot_sec
Q3U9F8
resolver
uniprot_sec
Q3UAQ8
resolver
uniprot_sec
Q8BN67
resolver
uniprot_sec
Q8CBT9
resolver
uniprot_sec
Q8CDL0
resolver
uniprot_sec
Q8CGI7
resolver
uniprot_sec
Q9D052
resolver
amino_acid_sequence
MAARSWQDELAQQAEEGSARLRELLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAPPTPAPDDLAQLKNLRSEEQKKKNRKKLPEKPKPNGRTVEVPEDEVVRNPRSITAKQAPETDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENIITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSRLNENLTVNGGGWSEKSVKLSSQLSEEKWNSVPPASAGKRKTEPSAWTQDTGDTNANGKDWGRNWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPSSDWNAPAEEWGNWVDEDRASLLKSQEPISNDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSHTQDTEDLEKDTREELPVNTSKARPKQEKACSLKTMSTSDPAEVLIKNSQPVKTLPPAISAEPSITLSKGDSDNSSSQVPPMLQDTDKPKSNAKQNSVPPSQTKSETNWESPKQIKKKKKARRET
uniprot
proteins
function
FUNCTION: Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
63846
uniprot
proteins
pubmed
14980505
uniprot
proteins
pubmed
15093543
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
579
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain. TNF causes translocation from the cytoplasm to the nucleus (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins