DPP3
entrez
10072
canonical
uniprot
Q9NY33
canonical
ensembl
ENSG00000254986
resolver
ensp
ENSP00000432782
resolver
ensp
ENSP00000436941
resolver
ensp
ENSP00000584308
resolver
genesymbol
DPP3
resolver
hgnc
HGNC:3008
resolver
uniprot
B2RDB5
resolver
uniprot
B4DLX4
resolver
uniprot
F5H8L6
resolver
uniprot
O95748
resolver
uniprot
Q969H2
resolver
uniprot
Q9BV67
resolver
uniprot
Q9HAL6
resolver
uniprot_entry
DPP3_HUMAN
resolver
uniprot_sec
B2RDB5
resolver
uniprot_sec
B4DLX4
resolver
uniprot_sec
F5H8L6
resolver
uniprot_sec
O95748
resolver
uniprot_sec
Q969H2
resolver
uniprot_sec
Q9BV67
resolver
uniprot_sec
Q9HAL6
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Co(2+). Inhibited by EDTA and o-phenanthroline (in vitro). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}.
uniprot
proteins
amino_acid_sequence
MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAYHLSRAAWYGGLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPKEKLERVILGSEAAQQHPEEVRGLWQTCGELMFSLEPRLRHLGLGKEGITTYFSGNCTMEDAKLAQDFLDSQNLSAYNTRLFKEVDGEGKPYYEVRLASVLGSEPSLDSEVTSKLKSYEFRGSPFQVTRGDYAPILQKVVEQLEKAKAYAANSHQGQMLAQYIESFTQGSIEAHKRGSRFWIQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAVVNKAMSAKFERLVASAEQLLKELPWPPTFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYATQREKLTFLEEDDKDLYILWKGPSFDVQVGLHELLGHGSGKLFVQDEKGAFNFDQETVINPETGEQIQSWYRSGETWDSKFSTIASSYEECRAESVGLYLCLHPQVLEIFGFEGADAEDVIYVNWLNMVRAGLLALEFYTPEAFNWRQAHMQARFVILRVLLEAGEGLVTITPTTGSDGRPDARVRLDRSKIRSVGKPALERFLRRLQVLKSTGDVAGGRALYEGYATVTDAPPECFLTLRDTVLLRKESRKLIVQPNTRLEGSDVQLLEYEASAAGLIRSFSERFPEDGPELEEILTQLATADARFWKGPSEAPSGQA
uniprot
proteins
ec_number
3.4.14.4
uniprot
proteins
function
FUNCTION: Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}.
uniprot
proteins
mass_dalton
82589
uniprot
proteins
protein_family
Peptidase M49 family
uniprot
proteins
pubmed
11209758
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
1515063
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22493238
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
3233187
uniprot
proteins
pubmed
9425109
uniprot
proteins
sequence_length
737
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187}.
uniprot
proteins