Dlx5
entrez
25431
canonical
uniprot
P50575
canonical
ensembl
ENSRNOG00000010905
resolver
ensembl
ENSRNOG00065010746
resolver
ensp
ENSRNOP00000014946
resolver
ensp
ENSRNOP00065013344
resolver
enst
ENSRNOT00000014946
resolver
enst
ENSRNOT00065017408
resolver
genesymbol
Dlx5
resolver
uniprot
A0A0G2JSK6
resolver
uniprot_entry
A0A0G2JSK6_RAT
resolver
uniprot_entry
DLX5_RAT
resolver
amino_acid_sequence
MTGVFDRRVPSIRSGDFQAPFPTSAAMHHPSQESPTLPESSATDSDYYSPAGAAPHGYCSPTSASYGKALNPYQYQYHSVNGSAAGYPAKAYADYGYASPYHQYGGAYNRVPSATSQPEKEVAEPEVRMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNKRSKIKKIMKNGEMPPEHSPSSSDPMACNSPQSPAVWEPQGSSRSLSHHPHAHPPTSNQSPASSYLENSASWYPSAASSINSHLPPPGSLQHPLALASGTLY
uniprot
proteins
function
FUNCTION: Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
31426
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation of Ser-34 and Ser-217 by MAPK14 enhances its transcriptional activity. Phosphorylation by CaMK2 increases its protein stability (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Distal-less homeobox family
uniprot
proteins
pubmed
7913069
uniprot
proteins
pubmed
7915995
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
uniprot
proteins