Trim69
entrez
70928
canonical
uniprot
Q80X56
canonical
ensembl
ENSMUSG00000033368
resolver
ensp
ENSMUSP00000047627
resolver
enst
ENSMUST00000036089
resolver
genesymbol
Trim69
resolver
genesymbol_syn
Rnf36
resolver
genesymbol_syn
Trif
resolver
uniprot
Q8VHZ6
resolver
uniprot_entry
TRI69_MOUSE
resolver
uniprot_sec
Q8VHZ6
resolver
amino_acid_sequence
MEVSSRPPSNFDPGNYVEMSDPTTTHLPSKVVIQDLTTELHCPLCNDWFRDPLMLTCGHNFCQDCIQSFWKVHSKETFCPDCKMLCQYSNCTFNLVLEKLVEKIKKLPLLKGHPQCPEHGENLKLFSKPEGKMICFQCKDARLSMGQSKDFLQISEAVRFFTEELAIYQSQLQTTLKELQSLRTIQKDAISAYKDNKIQLQQNLSLEFLKLHQFLHNKEKDILNDLRDEGKLLNEEMEVNLNQIQEQCLVAKDMLATIQARMEQQNSFDFLTDITKLIESMEKGMKTIVPRQLIAKKLSLGRFKGPIQYIIWKEMQAILSPGPSQLTLDPKTAHPNLVLSKSQTSVCHCDVKQVMPDDPERFDSSVAVLGSKGFTSGKWYWEIEVGKKTKWTIGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSRSLTLGDLRRVGVYLDYEGGQVSFYNATTMTHLYTFSSVFQEKLFPYLCPCLNDGGENKEPLHIVHPQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins, thereby limiting infection. Also involved in antiviral immunity by mediating 'Lys-63'-linked ubiquitination of STING1, thereby promoting STING1 dimerization and downstream activation of cGAS-STING signaling. In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity. Also plays a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination. Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1. {ECO:0000250|UniProtKB:Q86WT6}.
uniprot
proteins
mass_dalton
57312
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q86WT6}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation is necessary for nuclear localization. {ECO:0000269|PubMed:12837286}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11578878
uniprot
proteins
pubmed
12837286
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
33273151
uniprot
proteins
sequence_length
500
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86WT6}. Nucleus {ECO:0000250|UniProtKB:Q86WT6}. Nucleus speckle {ECO:0000250|UniProtKB:Q86WT6}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q86WT6}. Note=Adopts a filamentous distribution in the cell cytoplasm where it strongly colocalizes with stable microtubules. {ECO:0000250|UniProtKB:Q86WT6}.
uniprot
proteins