Pln
entrez
18821
canonical
uniprot
P61014
canonical
ensembl
ENSMUSG00000038583
resolver
ensp
ENSMUSP00000045709
resolver
ensp
ENSMUSP00000132743
resolver
ensp
ENSMUSP00000151641
resolver
ensp
ENSMUSP00000151745
resolver
ensp
ENSMUSP00000151860
resolver
ensp
ENSMUSP00000151966
resolver
enst
ENSMUST00000046221
resolver
enst
ENSMUST00000163319
resolver
enst
ENSMUST00000218468
resolver
enst
ENSMUST00000219491
resolver
enst
ENSMUST00000219921
resolver
enst
ENSMUST00000220197
resolver
genesymbol
Pln
resolver
uniprot
P20006
resolver
uniprot
Q3UQ75
resolver
uniprot_entry
PPLA_MOUSE
resolver
uniprot_sec
P20006
resolver
uniprot_sec
Q3UQ75
resolver
amino_acid_sequence
MEKVQYLTRSAIRRASTIEMPQQARQNLQNLFINFCLILICLLLICIIVMLL
uniprot
proteins
function
FUNCTION: Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:22971924, PubMed:27923914, PubMed:31449798). Binds preferentially to the ATP-bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle (By similarity). Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP (By similarity). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (PubMed:22971924, PubMed:26816378). Also inhibits the activity of ATP2A3/SERCA3 (PubMed:27923914). Controls intracellular Ca(2+) levels in elongated spermatids and may play a role in germ cell differentiation (PubMed:30733280). In the thalamic reticular nucleus of the brain, plays a role in the regulation of sleep patterns and executive functioning (PubMed:38493225). {ECO:0000250|UniProtKB:P61012, ECO:0000269|PubMed:22971924, ECO:0000269|PubMed:26816378, ECO:0000269|PubMed:27923914, ECO:0000269|PubMed:30733280, ECO:0000269|PubMed:31449798, ECO:0000269|PubMed:38493225}.
uniprot
proteins
mass_dalton
6095
uniprot
proteins
mutagenesis
MUTAGEN 20..22; /note="MPQ->GGG: No effect on inhibition of ATP2A1-mediated calcium uptake."; /evidence="ECO:0000269|PubMed:22971924"; MUTAGEN 20..21; /note="MP->GG: Nearly abolishes inhibition of ATP2A1-mediated calcium uptake."; MUTAGEN 21; /note="P->G: Reduces inhibition of ATP2A1-mediated calcium uptake."; /evidence="ECO:0000269|PubMed:22971924"; MUTAGEN 22; /note="Q->G: Strongly reduces inhibition of ATP2A1-mediated calcium uptake."; /evidence="ECO:0000269|PubMed:22971924"; MUTAGEN 32..36; /note="FINFC->AAAAA: Cleaved by SPPL2c."; /evidence="ECO:0000269|PubMed:30733280"; MUTAGEN 36..46; /note="CLILICLLLIC->ALILIALLLIA: Not cleaved by SPPL2c."; /evidence="ECO:0000269|PubMed:30733280"; MUTAGEN 36; /note="C->A: Abolishes palmitoylation."; /evidence="ECO:0000269|PubMed:26644582"; MUTAGEN 41; /note="C->A: Does not affect palmitoylation."; /evidence="ECO:0000269|PubMed:26644582"; MUTAGEN 42..46; /note="LLLIC->AAAAA: Cleaved by SPPL2c."; /evidence="ECO:0000269|PubMed:30733280"; MUTAGEN 46; /note="C->A: Does not affect palmitoylation."; /evidence="ECO:0000269|PubMed:26644582
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes (By similarity). Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. {ECO:0000250|UniProtKB:P26678, ECO:0000269|PubMed:20890288, ECO:0000269|PubMed:22971924}.; PTM: Palmitoylated by ZDHHC16, promoting formation of the homopentamer. {ECO:0000269|PubMed:26644582}.; PTM: In elongated spermatids, proteolytically cleaved by SPPL2C which modulates intracellular Ca(2+) homeostasis. {ECO:0000269|PubMed:1394867}.
uniprot
proteins
protein_family
Phospholamban family
uniprot
proteins
pubmed
1394867
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20890288
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22971924
uniprot
proteins
pubmed
26644582
uniprot
proteins
pubmed
26816378
uniprot
proteins
pubmed
27923914
uniprot
proteins
pubmed
30733280
uniprot
proteins
pubmed
31449798
uniprot
proteins
pubmed
38493225
uniprot
proteins
sequence_length
52
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26816378, ECO:0000269|PubMed:27923914, ECO:0000269|PubMed:30733280}; Single-pass membrane protein {ECO:0000255}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P26678}; Single-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:A4IFH6}; Single-pass membrane protein {ECO:0000255}. Membrane {ECO:0000269|PubMed:20890288}; Single-pass membrane protein {ECO:0000255}. Note=Colocalizes with HAX1 at the endoplasmic reticulum. Colocalizes with DMPK at the sarcoplasmic reticulum. {ECO:0000250|UniProtKB:P26678}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins