DIO2
entrez
1734
canonical
uniprot
Q92813
canonical
ensembl
ENSG00000211448
resolver
ensp
ENSP00000405854
resolver
ensp
ENSP00000451419
resolver
enst
ENST00000438257
resolver
enst
ENST00000557010
resolver
genesymbol
DIO2
resolver
genesymbol_syn
ITDI2
resolver
genesymbol_syn
TXDI2
resolver
hgnc
HGNC:2884
resolver
uniprot
A8K845
resolver
uniprot
B9EGK0
resolver
uniprot
G3V315
resolver
uniprot
Q6B0A3
resolver
uniprot
Q9HCP7
resolver
uniprot
Q9HCP8
resolver
uniprot
Q9P1W4
resolver
uniprot
Q9UDZ1
resolver
uniprot_entry
A8K845_HUMAN
resolver
uniprot_entry
IOD2_HUMAN
resolver
uniprot_sec
B9EGK0
resolver
uniprot_sec
G3V315
resolver
uniprot_sec
Q6B0A3
resolver
uniprot_sec
Q9HCP7
resolver
uniprot_sec
Q9HCP8
resolver
uniprot_sec
Q9P1W4
resolver
uniprot_sec
Q9UDZ1
resolver
amino_acid_sequence
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG
uniprot
proteins
ec_number
1.21.99.4
uniprot
proteins
function
FUNCTION: Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:12586771, PubMed:11108274, PubMed:10403186, PubMed:18821722). Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD) (PubMed:12586771, PubMed:11108274, PubMed:10403186, PubMed:18821722, PubMed:18339710). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'- diiodothyronamine (PubMed:18339710). {ECO:0000269|PubMed:10403186, ECO:0000269|PubMed:11108274, ECO:0000269|PubMed:12586771, ECO:0000269|PubMed:18339710, ECO:0000269|PubMed:18821722}.
uniprot
proteins
mass_dalton
30552
uniprot
proteins
mutagenesis
MUTAGEN 133; /note="U->A: Complete loss of enzyme activity towards L-thyroxine."; /evidence="ECO:0000269|PubMed:11108274"; MUTAGEN 133; /note="U->C: 1000-fold increase of Km and Vmax value for L-thyroxine."; /evidence="ECO:0000269|PubMed:11108274"; MUTAGEN 266; /note="U->C: No effect on enzyme activity towards L-thyroxine."; /evidence="ECO:0000269|PubMed:10403186
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MARCHF6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33. {ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:19651899}.
uniprot
proteins
protein_family
Iodothyronine deiodinase family
uniprot
proteins
pubmed
10403186
uniprot
proteins
pubmed
11089566
uniprot
proteins
pubmed
11108274
uniprot
proteins
pubmed
11165050
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12586771
uniprot
proteins
pubmed
12865408
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18339710
uniprot
proteins
pubmed
18821722
uniprot
proteins
pubmed
19651899
uniprot
proteins
pubmed
8755651
uniprot
proteins
pubmed
9837913
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11089566}; Single-pass type III membrane protein {ECO:0000305|PubMed:11089566}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..34; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins