Ntaq1
entrez
76773
canonical
uniprot
Q80WB5
canonical
ensembl
ENSMUSG00000022359
resolver
ensp
ENSMUSP00000064622
resolver
ensp
ENSMUSP00000154254
resolver
ensp
ENSMUSP00000154671
resolver
enst
ENSMUST00000067563
resolver
enst
ENSMUST00000226955
resolver
enst
ENSMUST00000227142
resolver
genesymbol
Ntaq1
resolver
genesymbol_syn
Wdyhv1
resolver
uniprot
A0A2I3BQY8
resolver
uniprot
A0A2I3BRR3
resolver
uniprot
Q9CWD7
resolver
uniprot_entry
A0A2I3BQY8_MOUSE
resolver
uniprot_entry
A0A2I3BRR3_MOUSE
resolver
uniprot_entry
NTAQ1_MOUSE
resolver
uniprot_entry
Q9CWD7_MOUSE
resolver
amino_acid_sequence
MEGDGPAATAPQYQPVCPTRDACVYNSCYCEENIWKLCEYIKTHNQYLLEECYAVFISNEKKMVPIWKQQARPENGPVIWDYHVVLLHVSREGQSFIYDLDTILPFPCPFDIYIEDALKSDDDIHLQFRRKFRVVRADSYLKHFASDRSHMKDSSGNWREPPPEYPCIETGDSKMNLNDFISMDPAVGWGAVYTLPEFVHRFSSKTYQA
uniprot
proteins
ec_number
3.5.1.122
uniprot
proteins
function
FUNCTION: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine. {ECO:0000269|PubMed:19560421}.
uniprot
proteins
mass_dalton
24337
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="C->A: Does not strongly affect N-terminal glutamine amidohydrolase activity."; /evidence="ECO:0000269|PubMed:19560421"; MUTAGEN 28; /note="C->A: Does not strongly affect N-terminal glutamine amidohydrolase activity."; /evidence="ECO:0000269|PubMed:19560421"; MUTAGEN 30; /note="C->A: Loss of N-terminal glutamine amidohydrolase activity."; /evidence="ECO:0000269|PubMed:19560421"; MUTAGEN 38; /note="C->A: Does not strongly affect N-terminal glutamine amidohydrolase activity."; /evidence="ECO:0000269|PubMed:19560421"; MUTAGEN 39; /note="E->Q: Does not strongly affect N-terminal glutamine amidohydrolase activity."; /evidence="ECO:0000269|PubMed:19560421"; MUTAGEN 81; /note="D->N: Impaired N-terminal glutamine amidohydrolase activity."; /evidence="ECO:0000269|PubMed:19560421"; MUTAGEN 83; /note="H->A: Loss of N-terminal glutamine amidohydrolase activity."; /evidence="ECO:0000269|PubMed:19560421"; MUTAGEN 147; /note="D->N: Does not strongly affect N-terminal glutamine amidohydrolase activity."; /evidence="ECO:0000269|PubMed:19560421
uniprot
proteins
protein_family
NTAQ1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19560421
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19560421}. Nucleus {ECO:0000269|PubMed:19560421}.
uniprot
proteins