C6
entrez
24237
canonical
uniprot
Q811M5
canonical
ensembl
ENSRNOG00000024115
resolver
ensp
ENSRNOP00000029891
resolver
enst
ENSRNOT00000033112
resolver
genesymbol
C6
resolver
uniprot
F1M7F7
resolver
uniprot_entry
CO6_RAT
resolver
uniprot_entry
F1M7F7_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Membrane attack complex (MAC) assembly is inhibited by CD59, thereby protecting self-cells from damage during complement activation. MAC assembly is also inhibited by clusterin (CLU) chaperones that inhibit polymerization of C9. {ECO:0000250|UniProtKB:P13671}.
uniprot
proteins
amino_acid_sequence
MTRHLTLCFILLIILIDKSEACFCDHYPWTHWSSCSKSCNSGTQSRQRQIVVNDYYRDNSCDQLCTKQETRQCNVETCPINCVLGDYGTWSDCDPCIRKQVKVRSVLRPSQFGGQPCTEPLVTFQPCVPSELCKIEETDCKNKFLCDSGRCIPSKLKCNGENDCGDNSDERNCGRTKPVCSRTYTPIPSVQLMGAGFHFLAGEPRGDVPDNSFTGGICKSVRSSRTSNPHRVPANLENVNFEVQTIEDDLKTDFYKDLATIGKNKNEDRSLSGEKKDSFYVPIFYSSKKSENFQRNSGFKNAIEASHKKDSSFVRIHKVIKVLNFTMKTTDLQLSDVFLKALIHLPLEYNFALYSRIFDDFGTHYFTSGSLGGKYDLLYQFSRQELQNSGLTEEETRNCVRYETKKRFLFFTKTYKEDRCTTNRLSEKYKGSFLQGSEKSISLVQGGRSQQAAALAWEKGSSGPEANVFSEWLESVKENPAVVDYELAPIIDLVRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPRLSGTECLCVCQSGTYGENCEKRSPDYKSNAVDGNWGCWSSWSACNAAYRRSRSRECNNPEPQRGGQRCEGKHWQEEDCTFSIMEKVGQPCISDDEEIKEVDLAEPEADSGCPQPPLPENAFVWNEKKLYSVGEEVEISCLTGFKAVGYQYFRCLPDRTWRQGDVECQRTECLKPVVQDVLTISPFQSVYKIGESIELTCPRGFVVAGPSRYTCKGDSWTPPIPNSLSCEKDILTKSKGLCQPGQKQSGSECVCMSPEEDCSSYSEDLCIFDEGSSQYFTSSACKFLAEKCLNSNQFHFVHAGSCQEGPQLEWGLERLKLAMKSTKRVPCGYDTCYDWEKCSAHTSNCVCLLPPQCPKDENQLHCVKMGSSMRGKTVNICTLGAVRCANRKVEILNPGRCLD
uniprot
proteins
function
FUNCTION: Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending. {ECO:0000250|UniProtKB:P13671}.
uniprot
proteins
mass_dalton
105114
uniprot
proteins
post_translational_modification
PTM: All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module. {ECO:0000250|UniProtKB:P13671}.
uniprot
proteins
protein_family
Complement C6/C7/C8/C9 family
uniprot
proteins
pubmed
15568620
uniprot
proteins
sequence_length
934
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P13671}. Target cell membrane {ECO:0000250|UniProtKB:P13671}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P13671}. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells. {ECO:0000250|UniProtKB:P13671}.
uniprot
proteins
transmembrane_region
TRANSMEM 278..290; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:P13671"; TRANSMEM 402..415; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:P13671
uniprot
proteins