Nr4a1
entrez
79240
canonical
uniprot
P22829
canonical
ensembl
ENSRNOG00000007607
resolver
ensembl
ENSRNOG00055029103
resolver
ensembl
ENSRNOG00060015611
resolver
ensp
ENSRNOP00000010171
resolver
ensp
ENSRNOP00000070558
resolver
ensp
ENSRNOP00055041483
resolver
ensp
ENSRNOP00060021406
resolver
enst
ENSRNOT00000010171
resolver
enst
ENSRNOT00055050397
resolver
enst
ENSRNOT00060026731
resolver
genesymbol
Nr4a1
resolver
genesymbol_syn
Hmr
resolver
genesymbol_syn
Ngfib
resolver
uniprot
Q4V8M4
resolver
uniprot_entry
NR4A1_RAT
resolver
uniprot_sec
Q4V8M4
resolver
amino_acid_sequence
MPCIQAQYGTPATSPGPRDHLTGDPLALEFSKPTMDLASPETAPTAPATLPSFSTFMDGGYTGEFDTFLYQLPGTAQPCSSASSTSSSSSSATSPASASFKFEDFQVYGCYPGTLSGPLDETLSSSGSDYYGSPCSAPSPPTPNFQPSQLSPWDGSFGHFSPSQTYEGLRVWTEQLPKASGPPPPPTFFSFSPPTGPSPSLAQSSLKLFPAPATHQLGEGESYSVPAAFPGLAPTSPNCDTSGILDAPVTSTKARSGSSGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKSAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPTNLLTSLIRAHLDSGPNTAKLDYSKFQELVLPRFGKEDAGDVQQFYDLLSGSLDVIRKWAEKIPGFIELSPGDQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDNILAFSRSLHSLGVDVPAFACLSALVLITDRHGLQDPRRVEELQNRIASCLKEHMAAVAGDPQPASCLSRLLGKLPELRTLCTQGLQRIFCLKLEDLVPPPPIVDKIFMDTLSF
uniprot
proteins
function
FUNCTION: Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:10331876). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (By similarity). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (By similarity). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (PubMed:8473329). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22736, ECO:0000269|PubMed:10331876, ECO:0000269|PubMed:8473329}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}.
uniprot
proteins
mass_dalton
64282
uniprot
proteins
mutagenesis
MUTAGEN 340; /note="S->A: Loss of phosphorylation."; /evidence="ECO:0000269|PubMed:8227042"; MUTAGEN 345; /note="R->K: Decreased NBRE binding."; /evidence="ECO:0000269|PubMed:8227042"; MUTAGEN 348; /note="L->V: Almost complete loss of NBRE binding."; /evidence="ECO:0000269|PubMed:8227042"; MUTAGEN 350; /note="S->A: Loss of phosphorylation."; /evidence="ECO:0000269|PubMed:8227042
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-350 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli (By similarity). Phosphorylation of Ser-350 results in decrease in NBRE binding while phosphorylation of Ser-340 has little effect on it. {ECO:0000250, ECO:0000269|PubMed:8227042}.; PTM: Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
NR4 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10331876
uniprot
proteins
pubmed
1314418
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15716272
uniprot
proteins
pubmed
3272167
uniprot
proteins
pubmed
8227042
uniprot
proteins
pubmed
8395013
uniprot
proteins
pubmed
8473329
uniprot
proteins
sequence_length
597
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:8227042}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P22736}. Mitochondrion {ECO:0000250|UniProtKB:P22736}. Note=Nuclear export to the cytosol is XPO1-mediated and positively regulated by IFI27. Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (By similarity). {ECO:0000250|UniProtKB:P22736}.
uniprot
proteins