Tmeff1
entrez
63845
canonical
uniprot
Q9QYV1
canonical
ensembl
ENSRNOG00000008034
resolver
ensembl
ENSRNOG00055020954
resolver
ensembl
ENSRNOG00060005254
resolver
ensembl
ENSRNOG00065010737
resolver
ensp
ENSRNOP00000063443
resolver
ensp
ENSRNOP00000103683
resolver
ensp
ENSRNOP00055029036
resolver
ensp
ENSRNOP00060006582
resolver
ensp
ENSRNOP00065013347
resolver
enst
ENSRNOT00000065775
resolver
enst
ENSRNOT00000136411
resolver
enst
ENSRNOT00055035779
resolver
enst
ENSRNOT00060008736
resolver
enst
ENSRNOT00065017411
resolver
genesymbol
Tmeff1
resolver
genesymbol_syn
Nc1
resolver
uniprot
A0ABK0LH72
resolver
uniprot_entry
A0ABK0LH72_RAT
resolver
uniprot_entry
TEFF1_RAT
resolver
amino_acid_sequence
MGAQAPLRLPAAPPLAVCGYTSVLLLFAFCLPGSGASNQPAGGGGDCPGGRGKSINCSELNLRESDIRACDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKDITVVARGPCYSDNGSGSGEGEEEGSGAGAHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIRQEQIDIRHLGHCTDTDDTSLLGKKDDGLQYRPDVKDAGDQREDVYIGSHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNRGRRQKQNLGHFTSETSSRMV
uniprot
proteins
function
FUNCTION: Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry. Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent. Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane. Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors. {ECO:0000250|UniProtKB:Q8IYR6}.
uniprot
proteins
mass_dalton
40143
uniprot
proteins
protein_family
Tomoregulin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IYR6}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 324..344; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins