Apbb1
entrez
11785
canonical
uniprot
Q9QXJ1
canonical
ensembl
ENSMUSG00000037032
resolver
ensp
ENSMUSP00000139575
resolver
ensp
ENSMUSP00000139788
resolver
ensp
ENSMUSP00000139899
resolver
ensp
ENSMUSP00000140116
resolver
ensp
ENSMUSP00000140486
resolver
ensp
ENSMUSP00000140973
resolver
ensp
ENSMUSP00000140979
resolver
ensp
ENSMUSP00000282281
resolver
ensp
ENSMUSP00000282292
resolver
enst
ENSMUST00000187057
resolver
enst
ENSMUST00000188368
resolver
enst
ENSMUST00000189072
resolver
enst
ENSMUST00000189378
resolver
enst
ENSMUST00000190369
resolver
enst
ENSMUST00000191011
resolver
enst
ENSMUST00000191601
resolver
genesymbol
Apbb1
resolver
genesymbol_syn
Fe65
resolver
genesymbol_syn
Rir
resolver
uniprot
A0A087WPI2
resolver
uniprot
A0A087WPS7
resolver
uniprot
A0A087WR62
resolver
uniprot
A0A0R4J2C1
resolver
uniprot
A0A0R4J2C6
resolver
uniprot
E9QNW5
resolver
uniprot
O08642
resolver
uniprot
Q3TPU0
resolver
uniprot
Q8BNF4
resolver
uniprot
Q8BSR9
resolver
uniprot_entry
A0A087WPI2_MOUSE
resolver
uniprot_entry
A0A087WPS7_MOUSE
resolver
uniprot_entry
A0A087WR62_MOUSE
resolver
uniprot_entry
A0A0R4J2C1_MOUSE
resolver
uniprot_entry
A0A0R4J2C6_MOUSE
resolver
uniprot_entry
APBB1_MOUSE
resolver
uniprot_sec
E9QNW5
resolver
uniprot_sec
O08642
resolver
uniprot_sec
Q3TPU0
resolver
uniprot_sec
Q8BNF4
resolver
uniprot_sec
Q8BSR9
resolver
amino_acid_sequence
MSVPSSLSQSAINANSHGGPALSFPLPLHAAHNQLLNAKLQATAVVPKDLRSAMGEGSVPEPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEAETAPLGPKGLMHLYSELELSAHNAANRGLHGSALIINTQEQGPDEGEEKAAGEAEEDDEDEEEEEEEEDLSSPPGLPEPLENVEVPSGPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHQEGFEEGEFWKDEPSEEAPMELGLKDPEEATLSFPAQSLSPEPVPQEEEKLSQRNANPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMAGGWGEGKDLLLQLEDETLKLVEPQNQTLLHAQPIVSIRVWGVGRDSGSNRDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMSERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQTSTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGSQTP
uniprot
proteins
function
FUNCTION: Transcription coregulator that can have both coactivator and corepressor functions (PubMed:17121854, PubMed:25342469). Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain (PubMed:17121854, PubMed:25342469). Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs) (By similarity). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (By similarity). Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (PubMed:27734846). Plays a role in the maintenance of lens transparency (PubMed:25757569). May play a role in muscle cell strength (PubMed:25757569, PubMed:27734846). Acts as a molecular adapter that functions in neurite outgrowth by activating the RAC1-ARF6 axis upon insulin treatment (By similarity). {ECO:0000250|UniProtKB:O00213, ECO:0000250|UniProtKB:P46933, ECO:0000269|PubMed:17121854, ECO:0000269|PubMed:25342469, ECO:0000269|PubMed:25757569, ECO:0000269|PubMed:27734846}.
uniprot
proteins
mass_dalton
77384
uniprot
proteins
mutagenesis
MUTAGEN 280; /note="W->F: Abolishes ligand binding; when associated with A-283."; /evidence="ECO:0000269|PubMed:9407065"; MUTAGEN 283; /note="P->A: Abolishes ligand binding; when associated with F-280."; /evidence="ECO:0000269|PubMed:9407065
uniprot
proteins
post_translational_modification
PTM: Polyubiquitination by RNF157 leads to degradation by the proteasome (PubMed:25342469). {ECO:0000269|PubMed:25342469}.; PTM: Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity). Phosphorylated following nuclear translocation. Phosphorylation at Tyr-546 by ABL1 enhances transcriptional activation activity and reduces the affinity for RASD1/DEXRAS1 (By similarity). {ECO:0000250|UniProtKB:O00213, ECO:0000250|UniProtKB:P46933}.; PTM: Acetylation at Lys-204 and Lys-701 by KAT5 promotes its transcription activator activity. Phosphorylated at Ser-459 by PKC upon insulin activation (By similarity). {ECO:0000250|UniProtKB:O00213}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17121854
uniprot
proteins
pubmed
19343227
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25342469
uniprot
proteins
pubmed
25757569
uniprot
proteins
pubmed
27734846
uniprot
proteins
pubmed
8894693
uniprot
proteins
pubmed
9407065
uniprot
proteins
sequence_length
710
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17121854}. Cytoplasm {ECO:0000269|PubMed:17121854}. Nucleus {ECO:0000269|PubMed:17121854}. Cell projection, growth cone {ECO:0000269|PubMed:19343227}. Nucleus speckle. Note=Colocalizes with TSHZ3 in the nucleus and in axonal growth cone (PubMed:19343227). Colocalizes with TSHZ3 in axonal growth cone (By similarity). Colocalizes with TSHZ3 in the nucleus (By similarity). In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP (By similarity). Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus (By similarity). Nuclear translocation is under the regulation of APP (By similarity). Colocalizes with NEK6 at the nuclear speckles (By similarity). Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity). {ECO:0000250|UniProtKB:O00213, ECO:0000250|UniProtKB:P46933, ECO:0000269|PubMed:19343227}.
uniprot
proteins