Trib3
entrez
246273
canonical
uniprot
Q9WTQ6
canonical
ensembl
ENSRNOG00000007319
resolver
ensembl
ENSRNOG00055025380
resolver
ensembl
ENSRNOG00060028116
resolver
ensembl
ENSRNOG00065022177
resolver
ensp
ENSRNOP00000009840
resolver
ensp
ENSRNOP00055035743
resolver
ensp
ENSRNOP00060040749
resolver
ensp
ENSRNOP00065030565
resolver
enst
ENSRNOT00000009840
resolver
enst
ENSRNOT00055043757
resolver
enst
ENSRNOT00060048841
resolver
enst
ENSRNOT00065037792
resolver
genesymbol
Trib3
resolver
genesymbol_syn
Nipk
resolver
uniprot
Q5BKD1
resolver
uniprot_entry
TRIB3_RAT
resolver
uniprot_sec
Q5BKD1
resolver
amino_acid_sequence
MRATSLAASADVPCRKKPLEFDDNIDVECPVLKRVRDEPEPGPTPSLPPASDLSPAVAPATRLGPYILLEREQGNCTYRALHCPTGTEYTCKVYPASEAQAVLAPYARLPTHQHVARPTEVLLGSQLLYTFFTKTHGDLHSLVRSRRGIPEPEAAALFRQMASAVAHCHKHGLILRDLKLRRFVFSNCERTKLVLENLEDACVMTGPDDSLWDKHACPAYVGPEILSSRPSYSGRAADVWSLGVALFTMLAGRYPFQDSEPALLFGKIRRGTFALPEGLSASARCLIRCLLRREPSERLVALGILLHPWLREDCSQVSPPRSDRREMDQVVPDGPQLEEAEEGEVGLYG
uniprot
proteins
function
FUNCTION: Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (By similarity). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (By similarity). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (By similarity). Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (PubMed:15469416). May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases (By similarity). Can inhibit APOBEC3A editing of nuclear DNA (By similarity). {ECO:0000250|UniProtKB:Q8K4K2, ECO:0000250|UniProtKB:Q96RU7, ECO:0000269|PubMed:15469416}.
uniprot
proteins
mass_dalton
38602
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tribbles subfamily
uniprot
proteins
pubmed
10329375
uniprot
proteins
pubmed
15469416
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8K4K2}.
uniprot
proteins