PRMT9
entrez
90826
canonical
uniprot
Q6P2P2
canonical
ensembl
ENSG00000164169
resolver
ensp
ENSP00000314396
resolver
ensp
ENSP00000610774
resolver
genesymbol
PRMT9
resolver
genesymbol_syn
PRMT10
resolver
hgnc
HGNC:25099
resolver
uniprot
A8KA39
resolver
uniprot
B3KU92
resolver
uniprot
Q6ZR58
resolver
uniprot
Q8N383
resolver
uniprot
Q9BT55
resolver
uniprot
Q9NT98
resolver
uniprot_entry
ANM9_HUMAN
resolver
uniprot_sec
A8KA39
resolver
uniprot_sec
B3KU92
resolver
uniprot_sec
Q6ZR58
resolver
uniprot_sec
Q8N383
resolver
uniprot_sec
Q9BT55
resolver
uniprot_sec
Q9NT98
resolver
amino_acid_sequence
MSNSRPRSRRDAGGGAGAAGRDELVSRSLQSAEHCLGVQDFGTAYAHYLLVLSLAPELKHDVKETFQYTLFRWAEELDALSRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFSDAKENFYRVANWLVERWHFIMLNDTKRNTIYNAAIQKAVCLGSKSVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVDAGLFGEGIVESLIHAWEHLLLQPKTKGESANCEKYGKVIPASAVIFGMAVECAEIRRHHRVGIKDIAGIHLPTNVKFQSPAYSSVDTEETIEPYTTEKMSRVPGGYLALTECFEIMTVDFNNLQELKSLATKKPDKIGIPVIKEGILDAIMVWFVLQLDDEHSLSTSPSEETCWEQAVYPVQDLADYWIKPGDHVMMEVSCQDCYLRIQSISVLGLECEMDVAKSFTQNKDLLSLGNEAELCSALANLQTSKPDAVEQTCILESTEIALLNNIPYHEGFKMAMSKVLSSLTPEKLYQTMDTHCQNEMSSGTGQSNTVQNILEPFYVLDVSEGFSVLPVIAGTLGQVKPYSSVEKDQHRIALDLISEANHFPKETLEFWLRHVEDESAMLQRPKSDKLWSIIILDVIEPSGLIQQEIMEKAAISRCLLQSGGKIFPQYVLMFGLLVESQTLLEENAVQGTERTLGLNIAPFINQFQVPIRVFLDLSSLPCIPLSKPVELLRLDLMTPYLNTSNREVKVYVCKSGRLTAIPFWYHMYLDEEIRLDTSSEASHWKQAAVVLDNPIQVEMGEELVLSIQHHKSNVSITVKQ
uniprot
proteins
ec_number
2.1.1.320
uniprot
proteins
function
FUNCTION: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed:25737013, PubMed:25979344). {ECO:0000269|PubMed:25737013, ECO:0000269|PubMed:25979344}.
uniprot
proteins
mass_dalton
94501
uniprot
proteins
mutagenesis
MUTAGEN 182..185; /note="LDIG->AAAA: Loss of interaction with SF3B2; Abolishes enzymatic activity."; /evidence="ECO:0000269|PubMed:25737013"; MUTAGEN 258; /note="D->G: Abolishes enzymatic activity."; /evidence="ECO:0000269|PubMed:25979344"; MUTAGEN 260; /note="G->E: Abolishes enzymatic activity."; /evidence="ECO:0000269|PubMed:25979344"; MUTAGEN 431; /note="C->H: 8-fold increase in MMA production and almost complete elimination of sDMA production."; /evidence="ECO:0000269|PubMed:27387499
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Protein arginine N-methyltransferase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17005254
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19300908
uniprot
proteins
pubmed
25737013
uniprot
proteins
pubmed
25979344
uniprot
proteins
pubmed
27387499
uniprot
proteins
sequence_length
845
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25737013, ECO:0000269|PubMed:25979344}.
uniprot
proteins