ARHGAP21
entrez
57584
canonical
uniprot
Q5T5U3
canonical
ensembl
ENSG00000107863
resolver
ensp
ENSP00000365592
resolver
ensp
ENSP00000379709
resolver
ensp
ENSP00000490396
resolver
ensp
ENSP00000573564
resolver
ensp
ENSP00000628494
resolver
ensp
ENSP00000628495
resolver
ensp
ENSP00000628497
resolver
ensp
ENSP00000708625
resolver
enst
ENST00000376410
resolver
enst
ENST00000958435
resolver
genesymbol
ARHGAP21
resolver
genesymbol_syn
ARHGAP10
resolver
genesymbol_syn
KIAA1424
resolver
hgnc
HGNC:23725
resolver
uniprot
A0A805TBS0
resolver
uniprot
Q0VF98
resolver
uniprot
Q7Z3P7
resolver
uniprot
Q8N3A2
resolver
uniprot
Q8NI19
resolver
uniprot
Q8TBV5
resolver
uniprot
Q9P2C3
resolver
uniprot_entry
A0A805TBS0_HUMAN
resolver
uniprot_entry
RHG21_HUMAN
resolver
uniprot_sec
Q0VF98
resolver
uniprot_sec
Q7Z3P7
resolver
uniprot_sec
Q8N3A2
resolver
uniprot_sec
Q8NI19
resolver
uniprot_sec
Q8TBV5
resolver
uniprot_sec
Q9P2C3
resolver
amino_acid_sequence
MMATRRTGLSEGDGDKLKACEVSKNKDGKEQSETVSLSEDETFSWPGPKTVTLKRTSQGFGFTLRHFIVYPPESAIQFSYKDEENGNRGGKQRNRLEPMDTIFVKQVKEGGPAFEAGLCTGDRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVMPKDEDILQVLQFTKDVTALAYSQDAYLKGNEAYSGNARNIPEPPPICYPWLPSAPSAMAQPVEISPPDSSLSKQQTSTPVLTQPGRAYRMEIQVPPSPTDVAKSNTAVCVCNESVRTVIVPSEKVVDLLSNRNNHTGPSHRTEEVRYGVSEQTSLKTVSRTTSPPLSIPTTHLIHQPAGSRSLEPSGILLKSGNYSGHSDGISSSRSQAVEAPSVSVNHYSPNSHQHIDWKNYKTYKEYIDNRRLHIGCRTIQERLDSLRAASQSTTDYNQVVPNRTTLQGRRRSTSHDRVPQSVQIRQRSVSQERLEDSVLMKYCPRSASQGALTSPSVSFSNHRTRSWDYIEGQDETLENVNSGTPIPDSNGEKKQTYKWSGFTEQDDRRGICERPRQQEIHKSFRGSNFTVAPSVVNSDNRRMSGRGVGSVSQFKKIPPDLKTLQSNRNFQTTCGMSLPRGISQDRSPLVKVRSNSLKAPSTHVTKPSFSQKSFVSIKDQRPVNHLHQNSLLNQQTWVRTDSAPDQQVETGKSPSLSGASAKPAPQSSENAGTSDLELPVSQRNQDLSLQEAETEQSDTLDNKEAVILREKPPSGRQTPQPLRHQSYILAVNDQETGSDTTCWLPNDARREVHIKRMEERKASSTSPPGDSLASIPFIDEPTSPSIDHDIAHIPASAVISASTSQVPSIATVPPCLTTSAPLIRRQLSHDHESVGPPSLDAQPNSKTERSKSYDEGLDDYREDAKLSFKHVSSLKGIKIADSQKSSEDSGSRKDSSSEVFSDAAKEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTTPSEEEQPISVNACLIDISYSETKRKNVFRLTTSDCECLFQAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGAEEPLTTVQEESTVDSQPVPNIDHLLTNIGRTGVSPGDVSDSATSDSTKSKGSWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQPSSSEDELDNVFFKKENVEQCHNDTKEESKKESETLGRKQKIIIAKENSTRKDPSTTKDEKISLGKESTPSEEPSPPHNSKHNKSPTLSCRFAILKESPRSLLAQKSSHLEETGSDSGTLLSTSSQASLARFSMKKSTSPETKHSEFLANVSTITSDYSTTSSATYLTSLDSSRLSPEVQSVAESKGDEADDERSELISEGRPVETDSESEFPVFPTALTSERLFRGKLQEVTKSSRRNSEGSELSCTEGSLTSSLDSRRQLFSSHKLIECDTLSRKKSARFKSDSGSLGDAKNEKEAPSLTKVFDVMKKGKSTGSLLTPTRGESEKQEPTWKTKIADRLKLRPRAPADDMFGVGNHKVNAETAKRKSIRRRHTLGGHRDATEISVLNFWKVHEQSGERESELSAVNRLKPKCSAQDLSISDWLARERLRTSTSDLSRGEIGDPQTENPSTREIATTDTPLSLHCNTGSSSSTLASTNRPLLSIPPQSPDQINGESFQNVSKNASSAANAQPHKLSETPGSKAEFHPCL
uniprot
proteins
function
FUNCTION: Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. {ECO:0000269|PubMed:15793564, ECO:0000269|PubMed:16184169}.
uniprot
proteins
mass_dalton
217462
uniprot
proteins
mutagenesis
MUTAGEN 1000; /note="Y->A: Altered interaction with ARF1 and loss of association to membranes."; /evidence="ECO:0000269|PubMed:17347647"; MUTAGEN 1054; /note="I->A: Altered interaction with ARF1 and loss of association to membranes."; /evidence="ECO:0000269|PubMed:17347647"; MUTAGEN 1184; /note="R->A: Loss of GTPase activity and loss of function."; /evidence="ECO:0000269|PubMed:15793564, ECO:0000269|PubMed:16184169
uniprot
proteins
post_translational_modification
PTM: Sumoylated with SUMO2 and SUMO3 in proliferating lymphocytes. {ECO:0000269|PubMed:22922005}.
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
12056806
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15375573
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15793564
uniprot
proteins
pubmed
16184169
uniprot
proteins
pubmed
16261155
uniprot
proteins
pubmed
16527809
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17347647
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22922005
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
1958
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1.
uniprot
proteins