EMC8
entrez
10328
canonical
uniprot
O43402
canonical
ensembl
ENSG00000131148
resolver
ensp
ENSP00000253457
resolver
ensp
ENSP00000391730
resolver
genesymbol
COX4NB
resolver
genesymbol
EMC8
resolver
genesymbol_syn
C16orf2
resolver
genesymbol_syn
C16orf4
resolver
genesymbol_syn
COX4AL
resolver
genesymbol_syn
COX4NB
resolver
genesymbol_syn
FAM158B
resolver
genesymbol_syn
NOC4
resolver
hgnc
HGNC:7864
resolver
uniprot
C9JB21
resolver
uniprot
Q53Y03
resolver
uniprot_entry
EMC8_HUMAN
resolver
uniprot_entry
Q53Y03_HUMAN
resolver
uniprot_sec
C9JB21
resolver
amino_acid_sequence
MPGVKLTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPRKEHLPLGGPGAHHTLFVDCIPLFHGTLALAPMLEVALTLIDSWCKDHSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFSDTALIMVDNTKFTMDCVAPTIHVYEHHENRWRCRDPHHDYCEDWPEAQRISASLLDSRSYETLVDFDNHLDDIRNDWTNPEINKAVLHLC
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000305}.
uniprot
proteins
mass_dalton
23773
uniprot
proteins
protein_family
EMC8/EMC9 family
uniprot
proteins
pubmed
10337626
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22119785
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29242231
uniprot
proteins
pubmed
29809151
uniprot
proteins
pubmed
30415835
uniprot
proteins
pubmed
32439656
uniprot
proteins
pubmed
32459176
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785}; Peripheral membrane protein {ECO:0000305|PubMed:32439656}; Cytoplasmic side {ECO:0000269|PubMed:32439656}.
uniprot
proteins