Sec61b
entrez
66212
canonical
uniprot
Q9CQS8
canonical
ensembl
ENSMUSG00000053317
resolver
ensp
ENSMUSP00000067681
resolver
enst
ENSMUST00000065678
resolver
genesymbol
Sec61b
resolver
uniprot_entry
SC61B_MOUSE
resolver
amino_acid_sequence
MPGPTPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIAAVFMLHIWGKYTRS
uniprot
proteins
function
FUNCTION: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (By similarity). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (By similarity). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity). Required for PKD1/Polycystin-1 biogenesis (PubMed:28375157). {ECO:0000250|UniProtKB:P60468, ECO:0000269|PubMed:28375157}.
uniprot
proteins
mass_dalton
9958
uniprot
proteins
protein_family
SEC61-beta family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
28375157
uniprot
proteins
sequence_length
96
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P60468}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins