TSPAN14
entrez
81619
canonical
uniprot
Q8NG11
canonical
ensembl
ENSG00000108219
resolver
ensp
ENSP00000361231
resolver
ensp
ENSP00000396270
resolver
ensp
ENSP00000418195
resolver
ensp
ENSP00000519706
resolver
ensp
ENSP00000519712
resolver
ensp
ENSP00000519713
resolver
ensp
ENSP00000519714
resolver
ensp
ENSP00000580535
resolver
ensp
ENSP00000580555
resolver
genesymbol
TSPAN14
resolver
genesymbol_syn
TM4SF14
resolver
hgnc
HGNC:23303
resolver
uniprot
A6NHE1
resolver
uniprot
B4DHY6
resolver
uniprot
D3DWD7
resolver
uniprot
D3DWD8
resolver
uniprot
Q567U7
resolver
uniprot
Q9BU34
resolver
uniprot
Q9H0U1
resolver
uniprot_entry
TSN14_HUMAN
resolver
uniprot_sec
A6NHE1
resolver
uniprot_sec
B4DHY6
resolver
uniprot_sec
D3DWD7
resolver
uniprot_sec
D3DWD8
resolver
uniprot_sec
Q567U7
resolver
uniprot_sec
Q9BU34
resolver
uniprot_sec
Q9H0U1
resolver
amino_acid_sequence
MHYYRYSNAKVSCWYKYLLFSYNIIFWLAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGIDPVVLVLMVGVVMFTLGFAGCVGALRENICLLNFFCGTIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDLQNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDVRIQLKSKWDESIFTKGCIQALESWLPRNIYIVAGVFIAISLLQIFGIFLARTLISDIEAVKAGHHF
uniprot
proteins
function
FUNCTION: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:23035126, PubMed:26668317, PubMed:26686862, PubMed:37516108). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity). {ECO:0000250|UniProtKB:Q8QZY6, ECO:0000269|PubMed:23035126, ECO:0000269|PubMed:26668317, ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:37516108}.
uniprot
proteins
mass_dalton
30691
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23035126
uniprot
proteins
pubmed
26668317
uniprot
proteins
pubmed
26686862
uniprot
proteins
pubmed
37516108
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26686862}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins