Isg15
entrez
100038882
canonical
uniprot
Q64339
canonical
ensembl
ENSMUSG00000035692
resolver
ensp
ENSMUSP00000082548
resolver
enst
ENSMUST00000085425
resolver
genesymbol
Isg15
resolver
genesymbol_syn
G1p2
resolver
genesymbol_syn
Ucrp
resolver
uniprot
Q4FJR9
resolver
uniprot
Q8K0H3
resolver
uniprot_entry
ISG15_MOUSE
resolver
uniprot_entry
Q4FJR9_MOUSE
resolver
uniprot_sec
Q8K0H3
resolver
amino_acid_sequence
MAWDLKVKMLGGNDFLVSVTNSMTVSELKKQIAQKIGVPAFQQRLAHQTAVLQDGLTLSSLGLGPSSTVMLVVQNCSEPLSILVRNERGHSNIYEVFLTQTVDTLKKKVSQREQVHEDQFWLSFEGRPMEDKELLGEYGLKPQCTVIKHLRLRGGGGDQCA
uniprot
proteins
function
FUNCTION: Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, TRIM25, STAT5A, MAPK1/ERK2 and globin. Isgylation of the viral sensor IFIH1/MDA5 promotes IFIH1/MDA5 oligomerization and triggers activation of innate immunity against a range of viruses, including coronaviruses, flaviviruses and picornaviruses. Can also isgylate: RIGI which inhibits its function in antiviral signaling response, IRF3 which inhibits its ubiquitination and degradation as well as EIF4E2 which enhances its cap structure-binding activity and translation-inhibition activity. Exhibits antiviral activity towards both DNA and RNA viruses, including influenza A and B virus, sindbis virus (SV) and herpes simplex type-1 (HHV-1). Plays a significant role in the control of neonatal Chikungunya virus (CHIKV) infection by acting as a putative immunomodulator of pro-inflammatory cytokines. Protects mice against the consequences of Chikungunya virus infection by down-regulating the pathogenic cytokine response, often denoted as the cytokine storm. Plays a role in erythroid differentiation. The secreted form of ISG15 can: induce natural killer cell proliferation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity. The secreted form acts through the integrin ITGAL/ITGB2 receptor to initiate activation of SRC family tyrosine kinases including LYN, HCK and FGR which leads to secretion of IFNG and IL10; the interaction is mediated by ITGAL (By similarity). {ECO:0000250|UniProtKB:P05161, ECO:0000269|PubMed:16254333, ECO:0000269|PubMed:17222803, ECO:0000269|PubMed:17227866, ECO:0000269|PubMed:17289916, ECO:0000269|PubMed:18057259, ECO:0000269|PubMed:22022510, ECO:0000269|PubMed:22028657, ECO:0000269|PubMed:22859821, ECO:0000269|PubMed:32726803}.
uniprot
proteins
mass_dalton
17898
uniprot
proteins
post_translational_modification
PTM: S-nitrosylation decreases its dimerization, thereby increasing the availability as well as the solubility of monomeric ISG15 for its conjugation to cellular proteins. {ECO:0000269|PubMed:18606809}.; PTM: Induced as an inactive, precursor protein that is cleaved by specific proteases to expose the C-terminal diglycine (LRLRGG) motif. This motif is essential not only for its conjugation to substrates but also for its recognition by the relevant processing proteases (By similarity). {ECO:0000250|UniProtKB:P05161}.
uniprot
proteins
pubmed
11859133
uniprot
proteins
pubmed
12582176
uniprot
proteins
pubmed
12963022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16254333
uniprot
proteins
pubmed
17222803
uniprot
proteins
pubmed
17227866
uniprot
proteins
pubmed
17289916
uniprot
proteins
pubmed
18057259
uniprot
proteins
pubmed
18606809
uniprot
proteins
pubmed
20946978
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22022510
uniprot
proteins
pubmed
22028657
uniprot
proteins
pubmed
22859821
uniprot
proteins
pubmed
32726803
uniprot
proteins
sequence_length
161
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P05161}. Secreted {ECO:0000250|UniProtKB:P05161}. Note=Exists in three distinct states: free within the cell, released into the extracellular space, or conjugated to target proteins. {ECO:0000250|UniProtKB:P05161}.
uniprot
proteins