Mzb1
entrez
69816
canonical
uniprot
Q9D8I1
canonical
ensembl
ENSMUSG00000024353
resolver
ensp
ENSMUSP00000025211
resolver
enst
ENSMUST00000025211
resolver
genesymbol
Mzb1
resolver
genesymbol_syn
Pacap
resolver
uniprot
D2IYS1
resolver
uniprot
Q6P3D3
resolver
uniprot
Q8BU13
resolver
uniprot
Q8K2M5
resolver
uniprot_entry
MZB1_MOUSE
resolver
uniprot_sec
D2IYS1
resolver
uniprot_sec
Q6P3D3
resolver
uniprot_sec
Q8BU13
resolver
uniprot_sec
Q8K2M5
resolver
amino_acid_sequence
MRLPLPLLLLFGCRAILGSAGDRVSLSASAPTLDDEEKYSAHMPAHLRCDACRAVAFQMGQRLAKAEAKSHTPDASGLQELSESTYTDVLDQTCSQNWQSYGVHEVNQMKRLTGPGLSKGPEPRISVMISGGPWPNRLSKTCFHYLGEFGEDQIYEAYRQGQANLEALLCGGTHGPCSQEILAQREEL
uniprot
proteins
function
FUNCTION: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.; FUNCTION: Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.
uniprot
proteins
mass_dalton
20580
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="C->A: Reduced electrophoretic mobility; when associated with A-52."; /evidence="ECO:0000269|PubMed:19805154"; MUTAGEN 52; /note="C->A: Reduced electrophoretic mobility; when associated with A-49."; /evidence="ECO:0000269|PubMed:19805154"; MUTAGEN 94; /note="C->A: Small loss of electrophoretic mobility."; /evidence="ECO:0000269|PubMed:19805154"; MUTAGEN 142; /note="C->A: Small loss of electrophoretic mobility."; /evidence="ECO:0000269|PubMed:19805154"; MUTAGEN 170; /note="C->A: Reduced electrophoretic mobility; when associated with A-177."; /evidence="ECO:0000269|PubMed:19805154"; MUTAGEN 177; /note="C->A: Reduced electrophoretic mobility; when associated with A-170."; /evidence="ECO:0000269|PubMed:19805154
uniprot
proteins
post_translational_modification
PTM: Forms an interchain disulfide bond with IgM monomers.
uniprot
proteins
protein_family
MZB1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19805154
uniprot
proteins
pubmed
19805157
uniprot
proteins
pubmed
21093319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21688198
uniprot
proteins
sequence_length
188
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:19805154}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:21093319}. Secreted {ECO:0000269|PubMed:21688198}.
uniprot
proteins