KYNU
entrez
8942
canonical
uniprot
Q16719
canonical
ensembl
ENSG00000115919
resolver
ensp
ENSP00000264170
resolver
ensp
ENSP00000364928
resolver
ensp
ENSP00000386731
resolver
ensp
ENSP00000664488
resolver
ensp
ENSP00000664494
resolver
ensp
ENSP00000763887
resolver
genesymbol
KYNU
resolver
hgnc
HGNC:6469
resolver
uniprot
B2RCZ5
resolver
uniprot
D3DP79
resolver
uniprot
Q6I9T2
resolver
uniprot
Q9BVW3
resolver
uniprot_entry
KYNU_HUMAN
resolver
uniprot_sec
B2RCZ5
resolver
uniprot_sec
D3DP79
resolver
uniprot_sec
Q6I9T2
resolver
uniprot_sec
Q9BVW3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by o-methoxybenzoylalanine (OMBA). {ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}.
uniprot
proteins
amino_acid_sequence
MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN
uniprot
proteins
disease_involvement
DISEASE: Hydroxykynureninuria (HYXKY) [MIM:236800]: An inborn error of amino acid metabolism characterized by massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid. Affected individuals manifest renal tubular dysfunction, metabolic acidosis, psychomotor retardation, non-progressive encephalopathy, and muscular hypertonia. {ECO:0000269|PubMed:17334708, ECO:0000269|PubMed:28792876}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Vertebral, cardiac, renal, and limb defects syndrome 2 (VCRL2) [MIM:617661]: An autosomal recessive congenital malformation syndrome characterized by vertebral segmentation abnormalities, congenital cardiac defects, renal defects, and distal mild limb defects. {ECO:0000269|PubMed:28792876}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.7.1.3
uniprot
proteins
function
FUNCTION: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. {ECO:0000269|PubMed:11985583, ECO:0000269|PubMed:17300176, ECO:0000269|PubMed:28792876, ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}.
uniprot
proteins
mass_dalton
52352
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. {ECO:0000255|HAMAP-Rule:MF_03017}.; PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. {ECO:0000255|HAMAP-Rule:MF_03017, ECO:0000269|PubMed:28792876}.
uniprot
proteins
protein_family
Kynureninase family
uniprot
proteins
pubmed
11985583
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17300176
uniprot
proteins
pubmed
17334708
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28792876
uniprot
proteins
pubmed
8706755
uniprot
proteins
pubmed
9180257
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_03017, ECO:0000269|PubMed:8706755}.
uniprot
proteins