Dact2
entrez
240025
canonical
uniprot
Q7TN08
canonical
ensembl
ENSMUSG00000048826
resolver
ensp
ENSMUSP00000051638
resolver
enst
ENSMUST00000053218
resolver
genesymbol
Dact2
resolver
genesymbol_syn
Dpr2
resolver
genesymbol_syn
Frd2
resolver
uniprot
Q6PDF4
resolver
uniprot
Q8BHZ7
resolver
uniprot_entry
DACT2_MOUSE
resolver
uniprot_sec
Q6PDF4
resolver
uniprot_sec
Q8BHZ7
resolver
amino_acid_sequence
MWAPSGQGPAGWDRRRVGARLRAALAGLQELQGLRATQQARVRGALGLHPAPGPRGQELRLEAALTALREQLSRLRRQDAGLKTHLDQLDQQISELQLDVSRSSCEALDSDSRPSSGFYELSDAGSCSLSTSCASVCSDRLSPSLGSWLPVFQPSKSRSGIGDWRPRSADETTVPAWSPQLTEDSRLLHGAEGTGRLTGMFRPRPVSTGDLERVLPADVGLQRAGTDAAHLLGQGIEIPAHALDPTYQRDLVARGGQEVYPYPSPLHAVALQSPLFALPKEAPCFDICSPPQEPPLVPVDENRTQPEPIRELGSAEAYIHRLLHLRGQELPLRDVGQEQGGDTAAFPPKPCGQRSESTCQLEKQACGADRGGLKLGRGAAKDSLKQHGPVSLVGAEPLSSPLKEETIPWNPCVHGDNTVGSSPCSQAQQPLNDCGQGPVLSPSRVLGTESPPLAPEPFAYTSCTTGETSPVKLRMGFSQNKAVKVRRRVSEKVPRLGKQLPPQPERQRVTERDPSRPHQGGLSRRPTLAREPPGRSCSESTLYPVPFLVPVVVAQRESYPTSPQAFFPMEAALLSSAARRKQRRWQSTMEISAKAGSVSQPGPSMGLPRSPAKRGSGPRAQSRPTLARQDACARCESDPSEHSADCTSLYHSTIAETSEDEEASDHTANRFGDESSSNDSEGCFRGSRRRLAIGSAEAGQGGWAWPRVPPQQPSRAPGNTRPPLPPVPKLCRIKASKALKKKIRRFQPAALKVMTMV
uniprot
proteins
function
FUNCTION: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling. {ECO:0000269|PubMed:17197390, ECO:0000269|PubMed:18716284, ECO:0000269|PubMed:20685821}.
uniprot
proteins
mass_dalton
81668
uniprot
proteins
protein_family
Dapper family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16881060
uniprot
proteins
pubmed
17197390
uniprot
proteins
pubmed
18716284
uniprot
proteins
pubmed
20685821
uniprot
proteins
pubmed
21718540
uniprot
proteins
sequence_length
757
uniprot
proteins