Pfn1
entrez
18643
canonical
uniprot
P62962
canonical
ensembl
ENSMUSG00000018293
resolver
ensp
ENSMUSP00000018437
resolver
enst
ENSMUST00000018437
resolver
genesymbol
Pfn1
resolver
uniprot
P10924
resolver
uniprot
Q3U7V7
resolver
uniprot
Q5SX50
resolver
uniprot_entry
PROF1_MOUSE
resolver
uniprot_entry
Q3U7V7_MOUSE
resolver
uniprot_entry
Q5SX50_MOUSE
resolver
uniprot_sec
P10924
resolver
amino_acid_sequence
MAGWNAYIDSLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVSITPAEVGVLVGKDRSSFFVNGLTLGGQKCSVIRDSLLQDGEFTMDLRTKSTGGAPTFNVTVTMTAKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY
uniprot
proteins
function
FUNCTION: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). {ECO:0000250|UniProtKB:P07737}.
uniprot
proteins
mass_dalton
14957
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation. {ECO:0000250|UniProtKB:P07737}.
uniprot
proteins
protein_family
Profilin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2717414
uniprot
proteins
sequence_length
140
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
uniprot
proteins