Errfi1
entrez
74155
canonical
uniprot
Q99JZ7
canonical
ensembl
ENSMUSG00000028967
resolver
ensp
ENSMUSP00000030811
resolver
ensp
ENSMUSP00000073285
resolver
enst
ENSMUST00000030811
resolver
enst
ENSMUST00000073600
resolver
genesymbol
Errfi1
resolver
genesymbol_syn
Mig6
resolver
uniprot
Q3TK48
resolver
uniprot_entry
ERRFI_MOUSE
resolver
uniprot_entry
Q3TK48_MOUSE
resolver
amino_acid_sequence
MSTAGVAAQDIRVPLKTGFLHNGQALGNMKSCWGSHSEFENNFLNIDPITMAYNLNSPAQEHLTTVGCAARSAPGSGHFFAECGPSPRSSLPPLVISPSESSGQREEDQVMCGFKKLSVNGVCTSTPPLTPIKSCPSPFPCAALCDRGSRPLPPLPISEDLCVDEADSEVELLTTSSDTDLLLEDSAPSDFKYDAPGRRSFRGCGQINYAYFDSPTVSVADLSCASDQNRVVPDPNPPPPQSHRRLRRSHSGPAGSFNKPAIRISSCTHRASPSSDEDKPEVPPRVPIPPRPAKPDYRRWSAEVTSNTYSDEDRPPKVPPREPLSRSNSRTPSPKSLPSYLNGVMPPTQSFAPDPKYVSSKALQRQSSEGSANKVPCILPIIENGKKVSSTHYYLLPERPPYLDKYEKYFKEAEETNPSTQIQPLPAACGMASATEKLASRMKIDMGSHGKRKHLSYVVSP
uniprot
proteins
function
FUNCTION: Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development. {ECO:0000269|PubMed:16648858, ECO:0000269|PubMed:19439667, ECO:0000269|PubMed:19683494, ECO:0000269|PubMed:19710174, ECO:0000269|PubMed:20018910}.
uniprot
proteins
mass_dalton
50075
uniprot
proteins
protein_family
MIG6 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16648858
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19439667
uniprot
proteins
pubmed
19683494
uniprot
proteins
pubmed
19710174
uniprot
proteins
pubmed
20018910
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16648858}. Cell membrane {ECO:0000269|PubMed:16648858}; Peripheral membrane protein {ECO:0000269|PubMed:16648858}; Cytoplasmic side {ECO:0000269|PubMed:16648858}. Nucleus {ECO:0000305|PubMed:16648858}. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes.
uniprot
proteins