Il12b
entrez
16160
canonical
uniprot
P43432
canonical
ensembl
ENSMUSG00000004296
resolver
ensp
ENSMUSP00000099860
resolver
ensp
ENSMUSP00000125867
resolver
enst
ENSMUST00000102796
resolver
enst
ENSMUST00000170513
resolver
genesymbol
Il12b
resolver
genesymbol_syn
IL12B
resolver
uniprot
Q3ZAX5
resolver
uniprot
Q9QUM1
resolver
uniprot_entry
IL12B_MOUSE
resolver
uniprot_entry
Q3ZAX5_MOUSE
resolver
uniprot_sec
Q9QUM1
resolver
amino_acid_sequence
MCPQKLTISWFAIVLLVSPLMAMWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRS
uniprot
proteins
function
FUNCTION: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. {ECO:0000250}.; FUNCTION: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. {ECO:0000269|PubMed:11114383}.
uniprot
proteins
mass_dalton
38235
uniprot
proteins
protein_family
IL-12B family
uniprot
proteins
pubmed
10438970
uniprot
proteins
pubmed
11114383
uniprot
proteins
pubmed
1350290
uniprot
proteins
pubmed
34374750
uniprot
proteins
pubmed
8647196
uniprot
proteins
sequence_length
335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34374750}.
uniprot
proteins