TPX2
entrez
22974
canonical
uniprot
Q9ULW0
canonical
ensembl
ENSG00000088325
resolver
ensp
ENSP00000300403
resolver
ensp
ENSP00000523998
resolver
ensp
ENSP00000523999
resolver
ensp
ENSP00000524000
resolver
ensp
ENSP00000524001
resolver
ensp
ENSP00000524005
resolver
genesymbol
HCTP4
resolver
genesymbol
TPX2
resolver
genesymbol_syn
C20orf1
resolver
genesymbol_syn
C20orf2
resolver
genesymbol_syn
DIL2
resolver
genesymbol_syn
HCA519
resolver
genesymbol_syn
TPX2
resolver
hgnc
HGNC:1249
resolver
uniprot
Q643R0
resolver
uniprot
Q96RR5
resolver
uniprot
Q9H1R4
resolver
uniprot
Q9NRA3
resolver
uniprot
Q9UFN9
resolver
uniprot
Q9UL00
resolver
uniprot
Q9Y2M1
resolver
uniprot_entry
Q643R0_HUMAN
resolver
uniprot_entry
TPX2_HUMAN
resolver
uniprot_sec
Q96RR5
resolver
uniprot_sec
Q9H1R4
resolver
uniprot_sec
Q9NRA3
resolver
uniprot_sec
Q9UFN9
resolver
uniprot_sec
Q9UL00
resolver
uniprot_sec
Q9Y2M1
resolver
amino_acid_sequence
MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPVDNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRKYQGLEIKSSDQPLTVPVSPKFSTRFHC
uniprot
proteins
function
FUNCTION: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}.
uniprot
proteins
mass_dalton
85653
uniprot
proteins
protein_family
TPX2 family
uniprot
proteins
pubmed
10393424
uniprot
proteins
pubmed
10512675
uniprot
proteins
pubmed
10871281
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12097419
uniprot
proteins
pubmed
14580337
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18662907
uniprot
proteins
pubmed
18663142
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19208764
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21242313
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25986610
uniprot
proteins
pubmed
26165940
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
37728657
uniprot
proteins
pubmed
9207457
uniprot
proteins
sequence_length
747
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19208764}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:37728657}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764}. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. {ECO:0000269|PubMed:19208764}.
uniprot
proteins