Nqo1
entrez
24314
canonical
uniprot
P05982
canonical
ensembl
ENSRNOG00000012772
resolver
ensembl
ENSRNOG00055020832
resolver
ensembl
ENSRNOG00060013067
resolver
ensembl
ENSRNOG00065011197
resolver
ensp
ENSRNOP00000017175
resolver
ensp
ENSRNOP00055028854
resolver
ensp
ENSRNOP00060017661
resolver
ensp
ENSRNOP00065013810
resolver
enst
ENSRNOT00055035578
resolver
enst
ENSRNOT00060022275
resolver
enst
ENSRNOT00065018126
resolver
genesymbol
Nqo1
resolver
genesymbol_syn
Nmor1
resolver
uniprot
Q63478
resolver
uniprot_entry
NQO1_RAT
resolver
uniprot_sec
Q63478
resolver
amino_acid_sequence
MAVRRALIVLAHAERTSFNYAMKEAAVEALKKKGWEVVESDLYAMNFNPLISRNDITGEPKDSENFQYPVESSLAYKEGRLSPDIVAEQKKLEAADLVIFQFPLYWFGVPAILKGWFERVLVAGFAYTYATMYDKGPFQNKKTLLSITTGGSGSMYSLQGVHGDMNVILWPIQSGILRFCGFQVLEPQLVYSIGHTPPDARVQVLEGWKKRLETVWEESPLYFAPSSLFDLNFQAGFLLKKEVQEEQKKNKFGLSVGHHLGKSIPADNQIKARK
uniprot
proteins
ec_number
1.6.5.2
uniprot
proteins
function
FUNCTION: Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (PubMed:1703398, PubMed:7862630, PubMed:8999809). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (By similarity). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (By similarity). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (By similarity). {ECO:0000250|UniProtKB:P15559, ECO:0000269|PubMed:1703398, ECO:0000269|PubMed:7862630, ECO:0000269|PubMed:8999809}.
uniprot
proteins
mass_dalton
30947
uniprot
proteins
mutagenesis
MUTAGEN 105; /note="Y->Q: Decreases the catalytic efficiency toward menadione and nitrobenzene substrates."; /evidence="ECO:0000269|PubMed:8999809"; MUTAGEN 117..118; /note="FE->KK: Destroys enzyme activity."; /evidence="ECO:0000269|PubMed:2141979"; MUTAGEN 131; /note="T->A: Decreases the catalytic efficiency toward menadione. Has no effect on the catalytic efficiency toward nitrobenzene substrate."; /evidence="ECO:0000269|PubMed:8999809"; MUTAGEN 161; /note="V->D: Destroys enzyme activity."; /evidence="ECO:0000269|PubMed:2141979"; MUTAGEN 164; /note="D->Q: Destroys enzyme activity."; /evidence="ECO:0000269|PubMed:2141979"; MUTAGEN 195; /note="H->A: Induces a very low catalytic efficiency."; /evidence="ECO:0000269|PubMed:7862630"; MUTAGEN 204; /note="V->I: Has no effect on the catalytic efficiency toward menadione and nitrobenzene substrates."; /evidence="ECO:0000269|PubMed:8999809"; MUTAGEN 219; /note="S->T: Has no effect on the catalytic efficiency toward menadione and nitrobenzene substrates."; /evidence="ECO:0000269|PubMed:8999809"; MUTAGEN 239; /note="L->M: Has no effect on the catalytic efficiency toward menadione. Slightly decreases the catalytic efficiency toward nitrobenzene substrate."; /evidence="ECO:0000269|PubMed:8999809
uniprot
proteins
protein_family
NAD(P)H dehydrogenase (quinone) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1703398
uniprot
proteins
pubmed
2141979
uniprot
proteins
pubmed
2480957
uniprot
proteins
pubmed
2499768
uniprot
proteins
pubmed
2504488
uniprot
proteins
pubmed
2963593
uniprot
proteins
pubmed
3100515
uniprot
proteins
pubmed
3143406
uniprot
proteins
pubmed
3144286
uniprot
proteins
pubmed
3536915
uniprot
proteins
pubmed
7568029
uniprot
proteins
pubmed
7862630
uniprot
proteins
pubmed
8999809
uniprot
proteins
sequence_length
274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:1703398}.
uniprot
proteins