Snai2
entrez
20583
canonical
uniprot
P97469
canonical
ensembl
ENSMUSG00000022676
resolver
ensp
ENSMUSP00000023356
resolver
enst
ENSMUST00000023356
resolver
genesymbol
Snai2
resolver
genesymbol_syn
Slug
resolver
genesymbol_syn
Slugh
resolver
uniprot
O09096
resolver
uniprot
Q3UZ96
resolver
uniprot
Q9R211
resolver
uniprot_entry
Q3UZ96_MOUSE
resolver
uniprot_entry
SNAI2_MOUSE
resolver
uniprot_sec
O09096
resolver
uniprot_sec
Q9R211
resolver
amino_acid_sequence
MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLYESYPIPVIPKPEILTSGAYSPITVWTSSAAPLHSPLPSGLSPLTGYSSSLGRVSPPPSSDTSSKDHSGSESPISDEEERLQPKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH
uniprot
proteins
function
FUNCTION: Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity). {ECO:0000250|UniProtKB:O43623}.
uniprot
proteins
mass_dalton
30003
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for ubiquitination. {ECO:0000250|UniProtKB:O43623}.; PTM: Ubiquitinated by the SCF(FBXO11) complex; ubiquitination requires previous GSK3B-mediated SNAI2 phosphorylation. {ECO:0000250|UniProtKB:O43623}.
uniprot
proteins
protein_family
Snail C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18331720
uniprot
proteins
pubmed
9182671
uniprot
proteins
pubmed
9838149
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43623}. Cytoplasm {ECO:0000250|UniProtKB:O43623}. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions (By similarity). {ECO:0000250|UniProtKB:O43623}.
uniprot
proteins