APOBEC3D
entrez
140564
canonical
uniprot
Q96AK3
canonical
ensembl
ENSG00000243811
resolver
ensembl
ENSG00000284554
resolver
ensp
ENSP00000216099
resolver
ensp
ENSP00000370980
resolver
ensp
ENSP00000388017
resolver
enst
ENST00000216099
resolver
enst
ENST00000381568
resolver
enst
ENST00000427494
resolver
genesymbol
APOBEC3D
resolver
genesymbol
APOBEC3DE
resolver
genesymbol
bK150C2.9
resolver
genesymbol_syn
APOBEC3DE
resolver
hgnc
HGNC:17354
resolver
uniprot
B2CML4
resolver
uniprot
F6WS13
resolver
uniprot
Q5JZ91
resolver
uniprot
Q6ICH2
resolver
uniprot
Q7Z2N2
resolver
uniprot
Q7Z2N5
resolver
uniprot
Q7Z2N6
resolver
uniprot_entry
ABC3D_HUMAN
resolver
uniprot_entry
B2CML4_HUMAN
resolver
uniprot_entry
F6WS13_HUMAN
resolver
uniprot_entry
Q6ICH2_HUMAN
resolver
uniprot_sec
Q5JZ91
resolver
uniprot_sec
Q7Z2N2
resolver
uniprot_sec
Q7Z2N5
resolver
uniprot_sec
Q7Z2N6
resolver
activity_regulation
ACTIVITY REGULATION: (Microbial infection) Antiviral activity is neutralized by the HIV-1 virion infectivity factor (Vif), that prevents its incorporation into progeny virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. {ECO:0000269|PubMed:21835787}.
uniprot
proteins
amino_acid_sequence
MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVLPKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFLAEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEDFAYCWENFVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWLCFTMEVTKHHSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ
uniprot
proteins
ec_number
3.5.4.38
uniprot
proteins
function
FUNCTION: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms (PubMed:16920826, PubMed:20062055, PubMed:21835787). Exhibits antiviral activity against HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA (PubMed:16920826). The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Also inhibits the mobility of LTR and non-LTR retrotransposons (PubMed:27428332). {ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:16920826, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22807680, ECO:0000269|PubMed:23097438, ECO:0000269|PubMed:23152537}.; FUNCTION: (Microbial infection) Enhances hepatitis B virus/HBV replication by excluding restriction factors APOBEC3F and APOBEC3G from HBV capsids. {ECO:0000269|PubMed:27289067}.
uniprot
proteins
mass_dalton
46598
uniprot
proteins
mutagenesis
MUTAGEN 140; /note="D->K: About two-third loss of anti HIV-1 activity."; /evidence="ECO:0000269|PubMed:16920826"; MUTAGEN 264; /note="E->Q: No effect on Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 268; /note="L->D: Resistant to HIV-1 Vif and abolishes Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 271; /note="F->A: Resistant to HIV-1 Vif and abolishes Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 272; /note="C->K: Resistant to HIV-1 Vif and reduces Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 275..276; /note="IL->AA: Resistant to HIV-1 Vif and abolishes Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 277; /note="S->D: Resistant to HIV-1 Vif and reduces Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 282; /note="Y->A: Resistant to HIV-1 Vif and abolishes Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 302; /note="E->K: Resistant to HIV-1 Vif and abolishes Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 303; /note="F->K: Resistant to HIV-1 Vif and abolishes Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 307; /note="H->D: Resistant to HIV-1 Vif and abolishes Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 337; /note="E->A: Resistant to HIV-1 Vif and reduces Vif binding."; /evidence="ECO:0000269|PubMed:23001005"; MUTAGEN 337; /note="E->K: Resistant to HIV-1 Vif and abolishes Vif binding."; /evidence="ECO:0000269|PubMed:23001005
uniprot
proteins
protein_family
Cytidine and deoxycytidylate deaminase family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11863358
uniprot
proteins
pubmed
12683974
uniprot
proteins
pubmed
12859895
uniprot
proteins
pubmed
16920826
uniprot
proteins
pubmed
18304004
uniprot
proteins
pubmed
20062055
uniprot
proteins
pubmed
20308164
uniprot
proteins
pubmed
21835787
uniprot
proteins
pubmed
22001110
uniprot
proteins
pubmed
22807680
uniprot
proteins
pubmed
22912627
uniprot
proteins
pubmed
22915799
uniprot
proteins
pubmed
23001005
uniprot
proteins
pubmed
23097438
uniprot
proteins
pubmed
23152537
uniprot
proteins
pubmed
27289067
uniprot
proteins
pubmed
27428332
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27289067, ECO:0000269|PubMed:27428332}. Cytoplasm, P-body.
uniprot
proteins