Slc2a1
entrez
20525
canonical
uniprot
P17809
canonical
ensembl
ENSMUSG00000028645
resolver
ensp
ENSMUSP00000030398
resolver
enst
ENSMUST00000030398
resolver
genesymbol
Slc2a1
resolver
genesymbol_syn
Glut1
resolver
uniprot
Q61608
resolver
uniprot
Q6GTI3
resolver
uniprot_entry
GTR1_MOUSE
resolver
uniprot_sec
Q61608
resolver
uniprot_sec
Q6GTI3
resolver
activity_regulation
ACTIVITY REGULATION: The uptake of glucose is inhibited by cytochalasin B. Glucose uptake is increased in response to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment: TPA-induced glucose uptake requires phosphorylation at Ser-226. {ECO:0000250|UniProtKB:P11166}.
uniprot
proteins
amino_acid_sequence
MDPSSKKVTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWNHRYGEPIPSTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVAAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNADLWPLLLSVIFIPALLQCILLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTRDLQEMKEEGRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAVLMTIALALLERLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
uniprot
proteins
function
FUNCTION: Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:17320047, PubMed:35810171). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (By similarity). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (PubMed:35810171). {ECO:0000250|UniProtKB:P11166, ECO:0000250|UniProtKB:P46896, ECO:0000269|PubMed:17320047, ECO:0000269|PubMed:25957687, ECO:0000269|PubMed:35810171}.
uniprot
proteins
mass_dalton
53985
uniprot
proteins
mutagenesis
MUTAGEN 485; /note="P->L: Lethality immediately after birth in knockin mice; caused by creation of a dileucine internalization motif that promotes mislocalization of the protein."; /evidence="ECO:0000269|PubMed:30197081
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-226 by PKC promotes glucose uptake by increasing cell membrane localization. {ECO:0000250|UniProtKB:P11166}.
uniprot
proteins
protein_family
Glucose transporter subfamily
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sugar transporter (TC 2.A.1.1) family
uniprot
proteins
pubmed
1289053
uniprot
proteins
pubmed
1339457
uniprot
proteins
pubmed
14578187
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17320047
uniprot
proteins
pubmed
1765007
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2190533
uniprot
proteins
pubmed
25957687
uniprot
proteins
pubmed
2654938
uniprot
proteins
pubmed
30197081
uniprot
proteins
pubmed
35810171
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17320047, ECO:0000269|PubMed:30197081, ECO:0000269|PubMed:35810171}; Multi-pass membrane protein {ECO:0000255}. Photoreceptor inner segment {ECO:0000269|PubMed:25957687}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..33; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 67..87; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 91..112; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 121..144; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 156..176; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 186..206; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 272..293; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 307..328; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 335..355; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 366..388; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 402..422; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 430..450; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P11166
uniprot
proteins