Pyy
entrez
217212
canonical
uniprot
Q9EPS2
canonical
ensembl
ENSMUSG00000017311
resolver
ensp
ENSMUSP00000017455
resolver
ensp
ENSMUSP00000134812
resolver
ensp
ENSMUSP00000135292
resolver
enst
ENSMUST00000017455
resolver
enst
ENSMUST00000127381
resolver
enst
ENSMUST00000177304
resolver
genesymbol
Pyy
resolver
uniprot
H3BK86
resolver
uniprot
Q3V334
resolver
uniprot
Q91XD0
resolver
uniprot_entry
H3BK86_MOUSE
resolver
uniprot_entry
PYY_MOUSE
resolver
uniprot_entry
Q3V334_MOUSE
resolver
uniprot_sec
Q91XD0
resolver
amino_acid_sequence
MVAVRRPWPVTVAMLLILLACLGALVDAYPAKPEAPGEDASPEELSRYYASLRHYLNLVTRQRYGKRDVPAALFSKLLFTDDSDSENLPFRPEGLDQW
uniprot
proteins
function
FUNCTION: [Peptide YY]: Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R). Also binds NPY5R. Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by PYY also leads to an increase of intracellular Ca(2+) levels (By similarity). This gut peptide inhibits exocrine pancreatic secretion (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (PubMed:21457230). {ECO:0000250|UniProtKB:P10082, ECO:0000250|UniProtKB:P68005, ECO:0000269|PubMed:21457230}.; FUNCTION: [Peptide YY(3-36)]: Is a NPY2R agonist involved in the down-regulation of appetite and food intake, probably acting on receptors located on proopiomelanocortin(POMC)-releasing and neuropeptide Y(NPY)-releasing neurons in the arcuate nucleus of hypothalamus (PubMed:12167864, PubMed:16280589). In NPY-releasing neurons, NPY2R activation by PYY(3-36) leads to membrane hyperpolarization and reduced release of the orexigenic neuropeptide NPY (PubMed:16280589). {ECO:0000269|PubMed:12167864, ECO:0000269|PubMed:16280589}.
uniprot
proteins
mass_dalton
11064
uniprot
proteins
post_translational_modification
PTM: The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36). {ECO:0000250|UniProtKB:P10082}.
uniprot
proteins
protein_family
NPY family
uniprot
proteins
pubmed
12167864
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16280589
uniprot
proteins
pubmed
21457230
uniprot
proteins
sequence_length
98
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Peptide YY]: Secreted {ECO:0000250|UniProtKB:P10082}.
uniprot
proteins