Eif3f
entrez
66085
canonical
uniprot
Q9DCH4
canonical
ensembl
ENSMUSG00000031029
resolver
ensp
ENSMUSP00000033342
resolver
enst
ENSMUST00000033342
resolver
genesymbol
Eif3f
resolver
genesymbol_syn
EIF3F
resolver
genesymbol_syn
EIF3S5
resolver
genesymbol_syn
Eif3s5
resolver
uniprot
Q3U8X1
resolver
uniprot
Q3UVY8
resolver
uniprot
Q5XJV3
resolver
uniprot_entry
EIF3F_MOUSE
resolver
uniprot_entry
Q3U8X1_MOUSE
resolver
uniprot_entry
Q3UVY8_MOUSE
resolver
uniprot_sec
Q5XJV3
resolver
amino_acid_sequence
MASPAVPANVPPATAAAAPAPVVTAAPASAPTPSTPAPTPAATPAASPAPVSSDPAVAAPAAPGQTPASAPAPAQTPAPSQPGPALPGPFPGGRVVRLHPVILASIVDSYERRNEGAARVIGTLLGTVDKHSVEVTNCFSVPHNESEDEVAVDMEFAKNMYELHKKVSPNELILGWYATGHDITEHSVLIHEYYSREAPNPIHLTVDTGLQHGRMSIKAYVSTLMGVPGRTMGVMFTPLTVKYAYYDTERIGVDLIMKTCFSPNRVIGLSSDLQQVGGASARIQDALSTVLQYAEDVLSGKVSADNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMVTYLANLTQSQIALNEKLVNL
uniprot
proteins
ec_number
3.4.19.12
uniprot
proteins
function
FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000255|HAMAP-Rule:MF_03005}.; FUNCTION: Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling. {ECO:0000255|HAMAP-Rule:MF_03005, ECO:0000269|PubMed:17581632}.
uniprot
proteins
mass_dalton
37984
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is enhanced upon serum stimulation. Phosphorylated during apoptosis by caspase-processed CDK11 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
EIF-3 subunit F family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16541103
uniprot
proteins
pubmed
17581632
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}.
uniprot
proteins