Cdk6
entrez
12571
canonical
uniprot
Q64261
canonical
ensembl
ENSMUSG00000040274
resolver
ensp
ENSMUSP00000037925
resolver
ensp
ENSMUSP00000126024
resolver
enst
ENSMUST00000042410
resolver
enst
ENSMUST00000165117
resolver
genesymbol
Cdk6
resolver
genesymbol_syn
Cdkn6
resolver
genesymbol_syn
Crk2
resolver
uniprot
Q0VBK8
resolver
uniprot
Q9R1D2
resolver
uniprot
Q9R1D3
resolver
uniprot_entry
CDK6_MOUSE
resolver
uniprot_entry
Q0VBK8_MOUSE
resolver
uniprot_sec
Q9R1D2
resolver
uniprot_sec
Q9R1D3
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Thr-177 phosphorylation and Tyr-24 dephosphorylation (By similarity). Rapidly down-regulated prior to cell differentiation (e.g. erythroid and osteoblast) (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MEKDSLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTSEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDIIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQDLERYKDNLNSHLPSNQSTSELNTA
uniprot
proteins
ec_number
2.7.11.22
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans (By similarity). May play a role in the centrosome organization during the cell cycle phases. {ECO:0000250|UniProtKB:Q00534, ECO:0000269|PubMed:16767702, ECO:0000269|PubMed:21319271, ECO:0000269|PubMed:21508411}.
uniprot
proteins
mass_dalton
37028
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="R->C: Enhanced kinase activity. Over-production of thymocytes and hematopoietic stem cells and progenitor cells."; /evidence="ECO:0000269|PubMed:21508411"; MUTAGEN 43; /note="K->M: Loss of kinase activity. Pronounced reduction in thymocytes and hematopoietic stem cells and progenitor cells."; /evidence="ECO:0000269|PubMed:21508411
uniprot
proteins
post_translational_modification
PTM: Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity. {ECO:0000250}.
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10384057
uniprot
proteins
pubmed
1459009
uniprot
proteins
pubmed
15315761
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16767702
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21319271
uniprot
proteins
pubmed
21508411
uniprot
proteins
pubmed
23918663
uniprot
proteins
pubmed
8444355
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q00534}. Nucleus {ECO:0000250|UniProtKB:Q00534}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q00534}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q00534}. Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (By similarity). Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus. {ECO:0000250|UniProtKB:Q00534, ECO:0000269|PubMed:23918663}.
uniprot
proteins