GRHL1
entrez
29841
canonical
uniprot
Q9NZI5
canonical
ensembl
ENSG00000134317
resolver
ensp
ENSP00000324693
resolver
ensp
ENSP00000384209
resolver
ensp
ENSP00000694442
resolver
genesymbol
GRHL1
resolver
genesymbol_syn
LBP32
resolver
genesymbol_syn
MGR
resolver
genesymbol_syn
TFCP2L2
resolver
hgnc
HGNC:17923
resolver
uniprot
A6NLA4
resolver
uniprot
B2R7E4
resolver
uniprot
B5MEC2
resolver
uniprot
Q53T93
resolver
uniprot
Q6NWN7
resolver
uniprot
Q6NWN8
resolver
uniprot
Q6NWN9
resolver
uniprot
Q8NI33
resolver
uniprot_entry
GRHL1_HUMAN
resolver
uniprot_sec
A6NLA4
resolver
uniprot_sec
B2R7E4
resolver
uniprot_sec
B5MEC2
resolver
uniprot_sec
Q53T93
resolver
uniprot_sec
Q6NWN7
resolver
uniprot_sec
Q6NWN8
resolver
uniprot_sec
Q6NWN9
resolver
uniprot_sec
Q8NI33
resolver
amino_acid_sequence
MTQEYDNKRPVLVLQNEALYPQRRSYTSEDEAWKSFLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRERRSSTAKPEVEHPEPDHSKRNSIPIVTEQPLISAGENRVQVLKNVPFNIVLPHGNQLGIDKRGHLTAPDTTVTVSIATMPTHSIKTETQPHGFAVGIPPAVYHPEPTERVVVFDRNLNTDQFSSGAQAPNAQRRTPDSTFSETFKEGVQEVFFPSDLSLRMPGMNSEDYVFDSVSGNNFEYTLEASKSLRQKPGDSTMTYLNKGQFYPITLKEVSSSEGIHHPISKVRSVIMVVFAEDKSREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNIEEIAYNAISFTWDINDEAKVFISVNCLSTDFSSQKGVKGLPLNIQVDTYSYNNRSNKPVHRAYCQIKVFCDKGAERKIRDEERKQSKRKVSDVKVPLLPSHKRMDITVFKPFIDLDTQPVLFIPDVHFANLQRGTHVLPIASEELEGEGSVLKRGPYGTEDDFAVPPSTKLARIEEPKRVLLYVRKESEEVFDALMLKTPSLKGLMEAISDKYDVPHDKIGKIFKKCKKGILVNMDDNIVKHYSNEDTFQLQIEEAGGSYKLTLTEI
uniprot
proteins
function
FUNCTION: Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204, PubMed:29309642). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, nor functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). May play a role in regulating glucose homeostasis and insulin signaling. {ECO:0000250|UniProtKB:Q921D9, ECO:0000269|PubMed:12175488, ECO:0000269|PubMed:18288204, ECO:0000269|PubMed:29309642, ECO:0000269|PubMed:35013237}.; FUNCTION: [Isoform 1]: Functions as a transcription activator. {ECO:0000269|PubMed:12175488, ECO:0000269|PubMed:29309642}.; FUNCTION: [Isoform 2]: May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed. {ECO:0000269|PubMed:12175488}.
uniprot
proteins
mass_dalton
70113
uniprot
proteins
mutagenesis
MUTAGEN 9; /note="R->A: Increases activity as transcriptional activator."; /evidence="ECO:0000269|PubMed:35013237"; MUTAGEN 116; /note="K->A: Reduces activity as transcriptional activator."; /evidence="ECO:0000269|PubMed:35013237"; MUTAGEN 378; /note="L->A: Decreases affinity for target DNA."; /evidence="ECO:0000269|PubMed:29309642"; MUTAGEN 380; /note="T->A: Decreases affinity for target DNA."; /evidence="ECO:0000269|PubMed:29309642"; MUTAGEN 385; /note="Q->A: Decreases affinity for target DNA."; /evidence="ECO:0000269|PubMed:29309642"; MUTAGEN 421; /note="C->A: No effect on affinity for target DNA."; /evidence="ECO:0000269|PubMed:29309642"; MUTAGEN 427; /note="R->A: Loss of activity as transcriptional activator. Strongly decreases affinity for target DNA."; /evidence="ECO:0000269|PubMed:29309642"; MUTAGEN 427; /note="R->Q: Loss of activity as transcriptional activator. Nearly abolishes affinity for target DNA. Causes steric hindrance that impedes DNA-binding by neighboring residues."; /evidence="ECO:0000269|PubMed:29309642"; MUTAGEN 428; /note="K->A: Decreases affinity for target DNA."; /evidence="ECO:0000269|PubMed:29309642"; MUTAGEN 430; /note="R->A: Decreases affinity for target DNA."; /evidence="ECO:0000269|PubMed:29309642
uniprot
proteins
post_translational_modification
PTM: Methylation at Arg-9 and Lys-116 may be involved in regulating transcriptional activation. {ECO:0000269|PubMed:35013237}.
uniprot
proteins
protein_family
Grainyhead subfamily
uniprot
proteins
protein_family
Grh/CP2 family
uniprot
proteins
pubmed
10644752
uniprot
proteins
pubmed
12175488
uniprot
proteins
pubmed
12549979
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18288204
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29309642
uniprot
proteins
pubmed
35013237
uniprot
proteins
sequence_length
618
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18288204, ECO:0000269|PubMed:35013237}.
uniprot
proteins