Ecsit
entrez
300447
canonical
uniprot
Q5XIC2
canonical
ensembl
ENSRNOG00000014128
resolver
ensembl
ENSRNOG00065014878
resolver
ensp
ENSRNOP00000019115
resolver
ensp
ENSRNOP00065019205
resolver
enst
ENSRNOT00000019115
resolver
enst
ENSRNOT00065024612
resolver
genesymbol
Ecsit
resolver
uniprot_entry
ECSIT_RAT
resolver
amino_acid_sequence
MSWVQVNLLARGLSRGWGSICRTVLSGTPFAQPSLQARGLHCSAVTHKDDVWLVPRPSEPQKKPIKVPAMHEDLFRPSGNGEQDKASFLNAVRSFGEHNVRKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFPKEVFRPRNAIQRIFVHYPRQQECGVAVLEQMERHGVMPNTETEFLLIQVFGHKSYPMLKFLRMKLWFTRFKNINPYPVPRDLPQDPLDLAKLGLRHMEPDLSAKVTVYQMSLPSESTGIEDPTQPHIVGIQSPDQQAALARHNPSRPVFVEGPFPLWLRNKCVYYHILRADLPPPEEETVEEIPEEWNLYYPMQLDLEYSRSAWDNYEFDMDEVTEGPVFAMCMTGAHDQATLVKWIQGLQETNPTLAQIPVVFRLARSTGELLATTRLEGQSPPHSPPKGPEEDDEAIQAQQRQGQS
uniprot
proteins
function
FUNCTION: Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling. Plays a role in the activation of NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to activate TAK1/MAP3K7 leading to activation of IKKs. Once ubiquitinated, interacts with the dissociated RELA and NFKB1 proteins and translocates to the nucleus where it induces NF-kappa-B-dependent gene expression. Plays a role in innate antiviral immune response by bridging the pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion (By similarity). Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). {ECO:0000250|UniProtKB:Q9BQ95, ECO:0000250|UniProtKB:Q9QZH6}.; FUNCTION: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I. {ECO:0000269|PubMed:22982022}.
uniprot
proteins
mass_dalton
49620
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated on Lys-371; leading to translocation in the nucleus together with RELA and NFKB1 and expression of NF-kappa-B-dependent genes. {ECO:0000250|UniProtKB:Q9BQ95}.
uniprot
proteins
protein_family
ECSIT family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22982022
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BQ95}. Nucleus {ECO:0000250|UniProtKB:Q9BQ95}. Mitochondrion {ECO:0000250|UniProtKB:Q9BQ95}.
uniprot
proteins