Q9QYU1
uniprot
Q9QYU1
canonical
amino_acid_sequence
MAAAEGGCGAGVEADRELEELLESALDDFDKAKPSPAPSPTISAPDASGPQKRSPGDTAKDALFASQEKFFQELFDSELASQATAEFEKAMKELAEEEPHLVEQFQKLSEAAGRVGSDASSQQEFTSCLKETLSGLAKNATDLQNSGMSEEELTKAMEGLGMDEGDGEGNILPIMQSLMQNLLSKDVLYPSLKEITEKYPEWLQSHQESIPPEQFEKYQQQHSVMGKICEQFEAETPTDSEATHRARFEAVLDLMQQLQDLGHPPKELAGEMPPGLNFDLDALNLSGPPGANGEQCLIM
uniprot
proteins
function
FUNCTION: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. {ECO:0000250|UniProtKB:P40855}.
uniprot
proteins
mass_dalton
32497
uniprot
proteins
protein_family
Peroxin-19 family
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P40855}. Peroxisome membrane {ECO:0000250|UniProtKB:P40855}; Lipid-anchor {ECO:0000250|UniProtKB:P40855}; Cytoplasmic side {ECO:0000250|UniProtKB:P40855}. Note=Mainly cytoplasmic, some fraction membrane-associated to the outer surface of peroxisomes. {ECO:0000250|UniProtKB:P40855}.
uniprot
proteins