RIN1
entrez
9610
canonical
uniprot
Q13671
canonical
ensembl
ENSG00000174791
resolver
ensp
ENSP00000310406
resolver
ensp
ENSP00000432798
resolver
ensp
ENSP00000539610
resolver
ensp
ENSP00000672206
resolver
genesymbol
RIN1
resolver
hgnc
HGNC:18749
resolver
uniprot
A0A0S2Z4T5
resolver
uniprot
A0A0S2Z4U0
resolver
uniprot
O15010
resolver
uniprot
Q00427
resolver
uniprot
Q96CC8
resolver
uniprot_entry
A0A0S2Z4T5_HUMAN
resolver
uniprot_entry
A0A0S2Z4U0_HUMAN
resolver
uniprot_entry
RIN1_HUMAN
resolver
uniprot_sec
O15010
resolver
uniprot_sec
Q00427
resolver
uniprot_sec
Q96CC8
resolver
amino_acid_sequence
MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRERLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSHYILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHLGIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAPERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPEKLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPLSPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCATKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRAAEE
uniprot
proteins
function
FUNCTION: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}.
uniprot
proteins
mass_dalton
84099
uniprot
proteins
mutagenesis
MUTAGEN 351; /note="S->A: Abolishes phosphorylation by PKD and the interaction with 14-3-3 proteins."; /evidence="ECO:0000269|PubMed:11784866
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins. {ECO:0000269|PubMed:11784866, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}.
uniprot
proteins
protein_family
RIN (Ras interaction/interference) family
uniprot
proteins
pubmed
11703925
uniprot
proteins
pubmed
11784866
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15886098
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
1849280
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
7862125
uniprot
proteins
pubmed
9144171
uniprot
proteins
pubmed
9208849
uniprot
proteins
sequence_length
783
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11784866}. Membrane {ECO:0000269|PubMed:11784866}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11784866}. Note=Some amount is membrane-associated.
uniprot
proteins