Thap1
entrez
73754
canonical
uniprot
Q8CHW1
canonical
ensembl
ENSMUSG00000037214
resolver
ensp
ENSMUSP00000042464
resolver
enst
ENSMUST00000036807
resolver
genesymbol
Thap1
resolver
uniprot_entry
THAP1_MOUSE
resolver
amino_acid_sequence
MVQSCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKQWEAAVKRKNFKPTKYSSICSEHFTPDCFKRECNNKLLKENAVPTIFLYIEPHEKKEDLESQEQLPSPSPPASQVDAAIGLLMPPLQTPDNLSVFCDHNYTVEDTMHQRKRILQLEQQVEKLRKKLKTAQQRCRRQERQLEKLKEVVHFQREKDDASERGYVILPNDYFEIVEVPA
uniprot
proteins
function
FUNCTION: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
24611
uniprot
proteins
protein_family
THAP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20200153
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}.
uniprot
proteins