ENSA
entrez
2029
canonical
uniprot
O43768
canonical
ensembl
ENSG00000143420
resolver
ensp
ENSP00000271690
resolver
ensp
ENSP00000341743
resolver
ensp
ENSP00000354835
resolver
ensp
ENSP00000355220
resolver
ensp
ENSP00000355239
resolver
ensp
ENSP00000358010
resolver
ensp
ENSP00000422343
resolver
ensp
ENSP00000424242
resolver
genesymbol
ENSA
resolver
hgnc
HGNC:3360
resolver
uniprot
A8K1Z9
resolver
uniprot
E9PB69
resolver
uniprot
Q5T5H2
resolver
uniprot
Q68D48
resolver
uniprot
Q6FHW0
resolver
uniprot
Q6IAM4
resolver
uniprot
Q6NUL2
resolver
uniprot
Q6VUC6
resolver
uniprot
Q6VUC7
resolver
uniprot
Q6VUC8
resolver
uniprot
Q6VUC9
resolver
uniprot
Q6VUD0
resolver
uniprot
Q6VUD1
resolver
uniprot
Q9NRZ0
resolver
uniprot_entry
ENSA_HUMAN
resolver
uniprot_sec
A8K1Z9
resolver
uniprot_sec
E9PB69
resolver
uniprot_sec
Q5T5H2
resolver
uniprot_sec
Q68D48
resolver
uniprot_sec
Q6FHW0
resolver
uniprot_sec
Q6IAM4
resolver
uniprot_sec
Q6NUL2
resolver
uniprot_sec
Q6VUC6
resolver
uniprot_sec
Q6VUC7
resolver
uniprot_sec
Q6VUC8
resolver
uniprot_sec
Q6VUC9
resolver
uniprot_sec
Q6VUD0
resolver
uniprot_sec
Q6VUD1
resolver
uniprot_sec
Q9NRZ0
resolver
amino_acid_sequence
MSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE
uniprot
proteins
function
FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. {ECO:0000250, ECO:0000269|PubMed:9653196}.
uniprot
proteins
mass_dalton
13389
uniprot
proteins
mutagenesis
MUTAGEN 109; /note="S->E: Mimicks a phosphorylated state and impairs interaction with SNCA."; /evidence="ECO:0000269|PubMed:18973346
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA. {ECO:0000250, ECO:0000269|PubMed:18973346, ECO:0000269|PubMed:9653196}.
uniprot
proteins
protein_family
Endosulfine family
uniprot
proteins
pubmed
10480622
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14728987
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17893145
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18973346
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9653196
uniprot
proteins
sequence_length
121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins