Pef1
entrez
67898
canonical
uniprot
Q8BFY6
canonical
ensembl
ENSMUSG00000028779
resolver
ensp
ENSMUSP00000030563
resolver
ensp
ENSMUSP00000112638
resolver
enst
ENSMUST00000030563
resolver
enst
ENSMUST00000118199
resolver
genesymbol
Pef1
resolver
uniprot
Q8VCT5
resolver
uniprot
Q9CYW8
resolver
uniprot
Q9D934
resolver
uniprot_entry
PEF1_MOUSE
resolver
uniprot_sec
Q8VCT5
resolver
uniprot_sec
Q9CYW8
resolver
uniprot_sec
Q9D934
resolver
amino_acid_sequence
MASYPNGQSCPGAAGQVPGVPPGGYYPGPPHGGGQYGSGLPPGGGYGAPAPGGPYGYPSAGGVPSGTPSGPYGGIPPGGPYGQLPPGGPYGTQPGHYGQGGVPPNVDPEAYSWFQSVDADHSGYISLKELKQALVNSNWSSFNDETCLMMINMFDKTKSGRIDVAGFSALWKFLQQWRNLFQQYDRDRSGSISSTELQQALSQMGYNLSPQFTQLLVSRYCARSAIPAMQLDCFIKVCTQLQVLTEAFREKDTAVQGNIRLSFEDFVTMTASRML
uniprot
proteins
function
FUNCTION: Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats. In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification. Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium. Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (By similarity). Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 (By similarity). {ECO:0000250|UniProtKB:Q641Z8, ECO:0000250|UniProtKB:Q9UBV8}.
uniprot
proteins
mass_dalton
29228
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex. {ECO:0000250|UniProtKB:Q9UBV8}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UBV8}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q641Z8}. Membrane {ECO:0000250|UniProtKB:Q9UBV8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UBV8}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q9UBV8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UBV8}. Note=Membrane-associated in the presence of Ca(2+) (By similarity). Localizes to endoplasmic reticulum exit site (ERES) (By similarity). {ECO:0000250|UniProtKB:Q641Z8, ECO:0000250|UniProtKB:Q9UBV8}.
uniprot
proteins