Grb14
entrez
50915
canonical
uniprot
Q9JLM9
canonical
ensembl
ENSMUSG00000026888
resolver
ensp
ENSMUSP00000028252
resolver
ensp
ENSMUSP00000225069
resolver
enst
ENSMUST00000028252
resolver
genesymbol
Grb14
resolver
uniprot
A2ASX2
resolver
uniprot
Q3UI77
resolver
uniprot
Q8VDI2
resolver
uniprot
Q9CR03
resolver
uniprot_entry
A2ASX2_MOUSE
resolver
uniprot_entry
GRB14_MOUSE
resolver
uniprot_sec
Q3UI77
resolver
uniprot_sec
Q8VDI2
resolver
uniprot_sec
Q9CR03
resolver
amino_acid_sequence
MTTSLQDGQSAAGRAGAQDSPLAVQVCRVAQGKGDAQDPAQVPGLHALSPASDATLRGAIDRRKMKDLDVLEKPPIPNPFPELCCSPLTSVLSAGLFPRANSRKKQVIKVYSEDETSRALEVPSDITARDVCQLLILKNHYVDDNSWTLFEHLSHIGLERTVEDHELPTEVLSHWGVEEDNKLYLRKNYAKYEFFKNPMYFFPEHMVSFAAEMNGDRSPTQILQVFLSSSTYPEIHGFLHAKEQGKKSWKKAYFFLRRSGLYFSTKGTSKEPRHLQLFSEFSTSHVYMSLAGKKKHGAPTPYGFCLKPNKAGGPRDLKMLCAEEEQSRTCWVTAIRLLKDGMQLYQNYMHPYQGRSACNSQSMSPMRSVSENSLVAMDFSGEKSRVIDNPTEALSVAVEEGLAWRKKGCLRLGNHGSPSAPSQSSAVNMALHRSQPWFHHRISRDEAQRLIIRQGPVDGVFLVRDSQSNPRTFVLSMSHGQKIKHYQIIPVEDDGELFHTLDDGHTKFTDLIQLVEFYQLNRGVLPCKLKHYCARMAV
uniprot
proteins
function
FUNCTION: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
60573
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
GRB7/10/14 family
uniprot
proteins
pubmed
10521483
uniprot
proteins
pubmed
10713090
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14449}. Endosome membrane {ECO:0000250|UniProtKB:Q14449}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14449}. Note=Upon insulin stimulation, translocates to the plasma membrane. {ECO:0000250|UniProtKB:Q14449}.
uniprot
proteins