Slc17a6
entrez
140919
canonical
uniprot
Q8BLE7
canonical
ensembl
ENSMUSG00000030500
resolver
ensp
ENSMUSP00000032710
resolver
enst
ENSMUST00000032710
resolver
genesymbol
Slc17a6
resolver
genesymbol_syn
Dnpi
resolver
genesymbol_syn
Vglut2
resolver
uniprot
A0A0R4J0A6
resolver
uniprot
Q920B7
resolver
uniprot_entry
A0A0R4J0A6_MOUSE
resolver
uniprot_entry
VGLU2_MOUSE
resolver
uniprot_sec
Q920B7
resolver
activity_regulation
ACTIVITY REGULATION: Chloride channel activity is allosterically activated by lumenal H(+) and Cl(-) leading to synaptic vesicles acidification. The L-glutamate transport activity is allosterically activated by lumenal H(+) and Cl(-). The allosteric requirement for H(+) efficiently prevents non-vesicular efflux across the plasma membrane (By similarity). The L-glutamate uniporter activity exhibits a biphasic dependence on chloride concentration (PubMed:11432869). {ECO:0000250|UniProtKB:Q9JI12, ECO:0000269|PubMed:11432869}.
uniprot
proteins
amino_acid_sequence
MESVKQRILAPGKEGIKNFAGKSLGQIYRVLEKKQDNRETIELTEDGKPLEVPEKKAPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISDGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYALFASGEKQPWADPEETSEEKCGFIHEDELDEETGDITQNYINYGTTKSYGATSQENGGWPNGWEKKEEFVQEGAQDAYTYKDRDDYS
uniprot
proteins
function
FUNCTION: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:11432869, PubMed:17108179, PubMed:25433636, PubMed:33440152). At the synaptic vesicle membrane, mainly functions as a uniporter which transports preferentially L-glutamate but also, phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:11432869, PubMed:17108179). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:11432869). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane therefore affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). Moreover, functions as a vesicular K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (PubMed:25433636). The vesicular H(+)/H(+) antiport activity is electroneutral (PubMed:25433636). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:33440152). The symporter activity is driven by an inside negative membrane potential and is electrogenic (PubMed:33440152). Also involved in the regulation of retinal hyaloid vessel regression during postnatal development (PubMed:30936473). May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas (By similarity). {ECO:0000250|UniProtKB:Q9JI12, ECO:0000269|PubMed:11432869, ECO:0000269|PubMed:17108179, ECO:0000269|PubMed:25433636, ECO:0000269|PubMed:30936473, ECO:0000269|PubMed:33440152}.
uniprot
proteins
mass_dalton
64561
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sodium/anion cotransporter family
uniprot
proteins
protein_family
VGLUT subfamily
uniprot
proteins
pubmed
11432869
uniprot
proteins
pubmed
12384506
uniprot
proteins
pubmed
15103023
uniprot
proteins
pubmed
15118123
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16942593
uniprot
proteins
pubmed
17108179
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25433636
uniprot
proteins
pubmed
30936473
uniprot
proteins
pubmed
33440152
uniprot
proteins
sequence_length
582
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:15103023, ECO:0000269|PubMed:16942593}; Multi-pass membrane protein {ECO:0000255}. Synapse, synaptosome {ECO:0000269|PubMed:16942593}. Cell membrane {ECO:0000305|PubMed:33440152}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 126..146; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 149..169; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 178..198; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 245..265; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 350..370; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 387..407; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 410..430; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 444..464; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 478..498; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins