Creb1
entrez
81646
canonical
uniprot
P15337
canonical
ensembl
ENSRNOG00000013412
resolver
ensembl
ENSRNOG00055022525
resolver
ensembl
ENSRNOG00060018985
resolver
ensembl
ENSRNOG00065026624
resolver
ensp
ENSRNOP00000018326
resolver
ensp
ENSRNOP00000087190
resolver
genesymbol
Creb1
resolver
genesymbol_syn
Creb-1
resolver
uniprot_entry
CREB1_RAT
resolver
amino_acid_sequence
MTMDSGADNQQSGDAAVTEAESQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
uniprot
proteins
function
FUNCTION: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (By similarity). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (PubMed:30566056). {ECO:0000250|UniProtKB:P16220, ECO:0000250|UniProtKB:P27925, ECO:0000250|UniProtKB:Q01147, ECO:0000269|PubMed:30566056}.
uniprot
proteins
mass_dalton
35081
uniprot
proteins
mutagenesis
MUTAGEN 119; /note="S->A: Loss of activation by CaMK4."; /evidence="ECO:0000269|PubMed:7958915"; MUTAGEN 128; /note="S->A: Loss of phosphorylation by CaMK2. Activation by CaMK2."; /evidence="ECO:0000269|PubMed:7958915
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-119 allows CREBBP binding. Stimulated by phosphorylation. Phosphorylation of both Ser-128 and Ser-119 in the SCN regulates the activity of CREB and participate in circadian rhythm generation (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-119. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-128. Phosphorylation of Ser-128 blocks CREB-mediated transcription even when Ser-119 is phosphorylated. Phosphorylated by CaMK1. Phosphorylation of Ser-257 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-119 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli (By similarity). CREBL2 positively regulates phosphorylation at Ser-119 thereby stimulating CREB1 transcriptional activity. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). Phosphorylated by TSSK4 on Ser-119 (By similarity). {ECO:0000250|UniProtKB:P16220}.; PTM: Sumoylated with SUMO1. Sumoylation on Lys-290, but not on Lys-271, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
10222196
uniprot
proteins
pubmed
1646483
uniprot
proteins
pubmed
1831258
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2521922
uniprot
proteins
pubmed
30566056
uniprot
proteins
pubmed
7958915
uniprot
proteins
pubmed
8621702
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins