Traf3ip3
entrez
215243
canonical
uniprot
Q8C0G2
canonical
ensembl
ENSMUSG00000037318
resolver
ensp
ENSMUSP00000040977
resolver
ensp
ENSMUSP00000141698
resolver
enst
ENSMUST00000043550
resolver
enst
ENSMUST00000192020
resolver
genesymbol
Traf3ip3
resolver
genesymbol_syn
T3jam
resolver
uniprot
B2RPU5
resolver
uniprot
G3X949
resolver
uniprot
Q8BY50
resolver
uniprot
Q8K1Y9
resolver
uniprot_entry
B2RPU5_MOUSE
resolver
uniprot_entry
G3X949_MOUSE
resolver
uniprot_entry
T3JAM_MOUSE
resolver
uniprot_sec
Q8BY50
resolver
uniprot_sec
Q8K1Y9
resolver
amino_acid_sequence
MISSDSRSSPGLARWAESYEAKCERRQETRENRRRRRNETTCRQPGKVLRTQHKERLQGARQLQFLKRRNLEEEKKGQAREQGPSSKTDGGTGQVSILKESLPGANKASFPGQQETGISSEVFPALHHSSSGIQRDLGGHHASHGRAFPPQDSDIKKPHRQHRGTQTKAEEALPTIKNDASQQTNCGVAVLDKDIIQLSEYLKEALHRELILKKKMVILQDLLPALIRASDSSWKGQLNEDKLKGKLRSLENQLYTCLQKHSPWGMKKVLLEMEDQRSSYEQKAKASLQKVLEEKMCAEQQLQRAQLSLALAEQKCQEWKSQYEALKEDWRTLGDQHRELESQLHVLQSKLQGADSRDSQMSQALQLLENEHQELQTKLESLQGDGEQQSSETQDLQDQLKKSEEEKQALVSKVQQLQSLLQNQSLQLQEQEKLLKKDQGLPVWNPKLSLDEVKPEGTRKEKEEELRDQLQKETFQLQVKENELQCGQWLPVLMVVIATALAVFLANKGNLVI
uniprot
proteins
function
FUNCTION: Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed:26195727). Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed:26195727). Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed:30115741). Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed:30115741). In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed:30115741). However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1 (By similarity). {ECO:0000250|UniProtKB:Q9Y228, ECO:0000269|PubMed:26195727, ECO:0000269|PubMed:30115741}.
uniprot
proteins
mass_dalton
58564
uniprot
proteins
pubmed
14572659
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26195727
uniprot
proteins
pubmed
30115741
uniprot
proteins
pubmed
31390091
uniprot
proteins
sequence_length
513
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Y228}. Golgi apparatus membrane {ECO:0000269|PubMed:26195727}; Single-pass type IV membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:30115741}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9Y228}. Note=Accumulates on the mitochondria after virus infection. {ECO:0000250|UniProtKB:Q9Y228}.
uniprot
proteins
transmembrane_region
TRANSMEM 486..506; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins