Slc40a1
entrez
53945
canonical
uniprot
Q9JHI9
canonical
ensembl
ENSMUSG00000025993
resolver
ensp
ENSMUSP00000027137
resolver
enst
ENSMUST00000027137
resolver
genesymbol
Slc40a1
resolver
genesymbol_syn
Fpn1
resolver
genesymbol_syn
Ireg1
resolver
genesymbol_syn
Slc11a3
resolver
genesymbol_syn
Slc39a1
resolver
uniprot
Q3UHZ9
resolver
uniprot
Q8BME5
resolver
uniprot
Q8BUM5
resolver
uniprot
Q9JIM9
resolver
uniprot
Q9JKP4
resolver
uniprot_entry
S40A1_MOUSE
resolver
uniprot_sec
Q3UHZ9
resolver
uniprot_sec
Q8BME5
resolver
uniprot_sec
Q8BUM5
resolver
uniprot_sec
Q9JIM9
resolver
uniprot_sec
Q9JKP4
resolver
amino_acid_sequence
MTKARDQTHQEGCCGSLANYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKNELLTMYHGWVLTVCYILIITIANIANLASTATAITIQRDWIVVVAGENRSRLADMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYFLLWKVYQKTPALAVKAALKVEESELKQLTSPKDTEPKPLEGTHLMGEKDSNIRELECEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLFSGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFVNVEPVSPTTKIPETVFTTEMHMSNMSNVHEMSTKPIPIVSVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHLMYFRFAQKTLGNQIFVCGPDEKEVTDENQPNTSVV
uniprot
proteins
function
FUNCTION: Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed:16054062, PubMed:30213870). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (PubMed:16054062, PubMed:30213870). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (By similarity). {ECO:0000250|UniProtKB:Q9NP59, ECO:0000269|PubMed:16054062, ECO:0000269|PubMed:30213870}.
uniprot
proteins
mass_dalton
62702
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated by RNF217; leading to proteasomal degradation (PubMed:33895792). Under conditions of high systemic iron levels, both the hormone peptide hepcidin/HAMP and holo(iron bound)-transferrin/TF induce the ubiquitination, internalization and proteasomal degradation of SLC40A1 to control iron release from cells (By similarity). {ECO:0000250|UniProtKB:Q9NP59, ECO:0000269|PubMed:33895792}.
uniprot
proteins
protein_family
Ferroportin (FP) (TC 2.A.100) family
uniprot
proteins
protein_family
SLC40A subfamily
uniprot
proteins
pubmed
10693807
uniprot
proteins
pubmed
10747949
uniprot
proteins
pubmed
10882071
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16054062
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
29599243
uniprot
proteins
pubmed
30213870
uniprot
proteins
pubmed
30888356
uniprot
proteins
pubmed
33895792
uniprot
proteins
sequence_length
570
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NP59}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NP59}. Basolateral cell membrane {ECO:0000269|PubMed:10693807}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NP59}. Note=Localized to the basolateral membrane of polarized epithelial cells. {ECO:0000269|PubMed:10693807}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..53; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 58..84; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 88..118; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 127..162; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 165..195; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 203..229; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 307..333; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 339..366; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 369..391; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 453..482; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 488..512; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 516..541; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59
uniprot
proteins