TMEM68
entrez
137695
canonical
uniprot
Q96MH6
canonical
ensembl
ENSG00000167904
resolver
ensp
ENSP00000335416
resolver
ensp
ENSP00000395204
resolver
ensp
ENSP00000429026
resolver
ensp
ENSP00000429210
resolver
ensp
ENSP00000429667
resolver
ensp
ENSP00000430542
resolver
ensp
ENSP00000609902
resolver
enst
ENST00000523073
resolver
genesymbol
TMEM68
resolver
hgnc
HGNC:26510
resolver
uniprot
E5RJN2
resolver
uniprot
Q658X6
resolver
uniprot
Q8WUD2
resolver
uniprot_entry
DIESL_HUMAN
resolver
uniprot_entry
E5RJN2_HUMAN
resolver
uniprot_sec
Q658X6
resolver
uniprot_sec
Q8WUD2
resolver
activity_regulation
ACTIVITY REGULATION: Acyltransferase activity is specifically inhibited by TMX1 at the endoplasmic reticulum, restricting accumulation of triacylglycerol. {ECO:0000269|PubMed:37648867}.
uniprot
proteins
amino_acid_sequence
MIDKNQTCGVGQDSVPYMICLIHILEEWFGVEQLEDYLNFANYLLWVFTPLILLILPYFTIFLLYLTIIFLHIYKRKNVLKEAYSHNLWDGARKTVATLWDGHAAVWHGYEVHGMEKIPEDGPALIIFYHGAIPIDFYYFMAKIFIHKGRTCRVVADHFVFKIPGFSLLLDVFCALHGPREKCVEILRSGHLLAISPGGVREALISDETYNIVWGHRRGFAQVAIDAKVPIIPMFTQNIREGFRSLGGTRLFRWLYEKFRYPFAPMYGGFPVKLRTYLGDPIPYDPQITAEELAEKTKNAVQALIDKHQRIPGNIMSALLERFH
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.20
uniprot
proteins
ec_number
2.3.1.22
uniprot
proteins
function
FUNCTION: Catalytic subunit of the alternative triglyceride biosynthesis pathway, which mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (PubMed:37648867). Synthesizes triacylglycerol at the expense of membrane phospholipids, such as phosphatidylcholine (PC) and its ether-linked form (ePC), thereby altering the composition of membranes (PubMed:37648867). The alternative triglyceride biosynthesis pathway is probably required to provide the energy required for rapid growth when fuel sources are limiting (PubMed:37648867). It maintains mitochondrial function during periods of extracellular lipid starvation (PubMed:37648867). Can also use acyl-CoA as donor: acts as a acyl-CoA:monoacylglycerol acyltransferase (MGAT), but also shows acyl-CoA:diacylglycerol acyltransferase (DGAT) activity (By similarity). {ECO:0000250|UniProtKB:Q9D850, ECO:0000269|PubMed:37648867}.
uniprot
proteins
mass_dalton
37425
uniprot
proteins
mutagenesis
MUTAGEN 130; /note="H->A: Abolished acyltransferase activity."; /evidence="ECO:0000269|PubMed:37648867
uniprot
proteins
protein_family
Diacylglycerol acyltransferase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
37648867
uniprot
proteins
sequence_length
324
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:37648867}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..71; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 126..146; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins