Slc7a7
entrez
83509
canonical
uniprot
Q9R0S5
canonical
ensembl
ENSRNOG00000010296
resolver
ensembl
ENSRNOG00055011879
resolver
ensembl
ENSRNOG00060027322
resolver
ensembl
ENSRNOG00065031287
resolver
ensp
ENSRNOP00000014391
resolver
ensp
ENSRNOP00055016295
resolver
ensp
ENSRNOP00060039470
resolver
ensp
ENSRNOP00065044399
resolver
enst
ENSRNOT00000014391
resolver
enst
ENSRNOT00055020211
resolver
enst
ENSRNOT00060047414
resolver
enst
ENSRNOT00065053967
resolver
genesymbol
Slc7a7
resolver
uniprot
Q9QZ66
resolver
uniprot_entry
YLAT1_RAT
resolver
uniprot_sec
Q9QZ66
resolver
amino_acid_sequence
MVASTKYEVAAQNEADEADGSAQGDGAGPAAEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLMYSASFGLSLVIWAVGGIFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAVIAITFANYMVQPLFPSCGAPYAAGRLLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIIAGIVRLGQGATTNFEDSFEGSSFAMGDIALALYSALFSYSGWDTLNYVTEEIRNPERNLPLSIGISMPIVTIIYLLTNVAYYSVLDIKDILASDAVAVTFADQIFGIFNWTIPLAVALSCFGGLNASIVAASRLLFVGSREGHLPDAICMIHVERFTPVPSLLFNGILALVYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWKEPDRPRPLKLSLFFPIVFCLCTIFLVAVPLYSDTINSLIGIGIALSGLPFYFLIIRVPEHKRPLCLRRIVASTTRYLQIICMSVAAEMDLEDGELPKQGPKSK
uniprot
proteins
function
FUNCTION: Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:10777485). Also mediates L-arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (By similarity). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10777485). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (PubMed:10777485). {ECO:0000250|UniProtKB:Q9UM01, ECO:0000269|PubMed:10777485}.
uniprot
proteins
mass_dalton
55641
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
protein_family
L-type amino acid transporter (LAT) (TC 2.A.3.8) family
uniprot
proteins
pubmed
10777485
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9878049
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:Q9UM01}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 262..282; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 307..327; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 386..406; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 419..439; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 444..464; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins