Aloxe3
entrez
23801
canonical
uniprot
Q9WV07
canonical
ensembl
ENSMUSG00000020892
resolver
ensp
ENSMUSP00000021268
resolver
enst
ENSMUST00000021268
resolver
genesymbol
Aloxe3
resolver
uniprot
B1ASX3
resolver
uniprot
Q14B96
resolver
uniprot_entry
LOXE3_MOUSE
resolver
uniprot_entry
Q14B96_MOUSE
resolver
uniprot_sec
B1ASX3
resolver
amino_acid_sequence
MAVYRLCVTTGSYLKAGTLDNIYATLVGTCGESPKQKLDRVGRDFASGSVQKYKVRCEAELGEILLLRLHKERFAFFCKDPWYCSRICVTAPDGSAVHFPCYQWIDGYCTVELRPGTARTICQDSLPLLLDHRKRELQARQECYRWKIFAPGFPRMVDVSSFQEMESDKKFALTKTVPCAEQDDNSGNRYLPGFPMKIDIPSLLHMEPNIRYSATKTASLIFNALPASFGMKIRGLLDRKGSWKRLDDIRNIFWCHKTFTSEYVTEHWCEDSFFGYQYLNGVNPVMLHCLSSLPSKLPVTNDMVAPLLGPGTCLQTELERGHIFLADYWILAEAPVHCINGLQQYVTAPLCLLWLNPQGVLLPLAIQLSQTPGPESPIFLPTDCELDWLLAKTWVRNSEFLVHENNTHFLCTHLLCEAFSMATLRQLPLCHPVYKLLLPHTRYTLQVNTIARATLLNPDGLVDKVTSIGRQGLIYLMSTGLAHFTYTDFCLPDSIRARGVLTIPNYHYRDDGLKIWAAIERFVSEIVSYYYPSDASVQQDCELQAWVGEIFAQAFLGRESSGFPSRLCTPGELVKYLTAIIFNCSAQHAAVNSGQHDFGAWMPNAPSSMRQPPPQTKGDTTMKSYLDTLPEVNTTCRNLLLFWLVSQEPKDQRPLGTYPDEHFTEEAPRQSIAAFQNCLAQISKDIRERNQSLALPYAYLDPPLIENSVSI
uniprot
proteins
ec_number
4.2.1.152
uniprot
proteins
ec_number
5.4.4.7
uniprot
proteins
function
FUNCTION: Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity (PubMed:17045234). The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones (PubMed:17045234). In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins (By similarity). Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PubMed:22832496). In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites (By similarity). Also plays a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG (PubMed:20530198). Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (By similarity). {ECO:0000250|UniProtKB:D3ZKX9, ECO:0000250|UniProtKB:Q9BYJ1, ECO:0000269|PubMed:17045234, ECO:0000269|PubMed:20530198, ECO:0000269|PubMed:22832496}.
uniprot
proteins
mass_dalton
80473
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. {ECO:0000269|PubMed:17045234}.; PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000250|UniProtKB:Q9BYJ1}.
uniprot
proteins
protein_family
Lipoxygenase family
uniprot
proteins
pubmed
10366447
uniprot
proteins
pubmed
17045234
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20530198
uniprot
proteins
pubmed
22832496
uniprot
proteins
sequence_length
711
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00726}.
uniprot
proteins