Alkbh3
entrez
362169
canonical
uniprot
Q5XIC8
canonical
ensembl
ENSRNOG00000021678
resolver
ensembl
ENSRNOG00055016937
resolver
ensembl
ENSRNOG00060002989
resolver
ensembl
ENSRNOG00065025185
resolver
ensp
ENSRNOP00000093084
resolver
ensp
ENSRNOP00055023179
resolver
ensp
ENSRNOP00060003545
resolver
ensp
ENSRNOP00065035576
resolver
enst
ENSRNOT00055028781
resolver
enst
ENSRNOT00060004884
resolver
enst
ENSRNOT00065043381
resolver
genesymbol
Alkbh3
resolver
genesymbol_syn
Abh3
resolver
uniprot_entry
ALKB3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by ascorbate. {ECO:0000250|UniProtKB:Q96Q83}.
uniprot
proteins
amino_acid_sequence
MGDKRQRARVQGAWATPTKSQSAARPATPARSRPSQTPGPSWRSKEQQQCDRRFVFKEPQLVVRAAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDLKEADWILERLCQDVPWKQRMGIREDITYPQPRLTAWYGELPYTYSRVTMEPNPHWLPVLWTLKSRIEENTGHTFNSLLCNFYRDEKDSVDWHSDDEPSLGSCPVIASLSFGATRTFEMRKKPPPEENGDYTYVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSRERRVNLTFRTVYPDPRGAPGDTSAELPLR
uniprot
proteins
ec_number
1.14.11.33
uniprot
proteins
ec_number
1.14.11.54
uniprot
proteins
function
FUNCTION: Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Can repair exocyclic 3,N4-ethenocytosine adducs in single-stranded DNA. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron. {ECO:0000250|UniProtKB:Q96Q83}.
uniprot
proteins
mass_dalton
34011
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination. OTUD4 promotes USP7 and USP9X-dependent deubiquitination of 'Lys-48'-polyubiquitinated ALKBH3 promoting the repair of alkylated DNA lesions. {ECO:0000250|UniProtKB:Q96Q83}.
uniprot
proteins
protein_family
AlkB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96Q83}. Cytoplasm {ECO:0000250|UniProtKB:Q96Q83}. Note=Colocalizes with ASCC2 and ASCC3 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. Predominantly localizes to the nucleus. {ECO:0000250|UniProtKB:Q96Q83}.
uniprot
proteins