Il17f
entrez
257630
canonical
uniprot
Q7TNI7
canonical
ensembl
ENSMUSG00000041872
resolver
ensp
ENSMUSP00000046960
resolver
ensp
ENSMUSP00000140122
resolver
genesymbol
Il17f
resolver
uniprot
Q8K4C3
resolver
uniprot_entry
IL17F_MOUSE
resolver
uniprot_sec
Q8K4C3
resolver
amino_acid_sequence
MKCTRETAMVKSLLLLMLGLAILREVAARKNPKAGVPALQKAGNCPPLEDNTVRVDIRIFNQNQGISVPREFQNRSSSPWDYNITRDPHRFPSEIAEAQCRHSGCINAQGQEDSTMNSVAIQQEILVLRREPQGCSNSFRLEKMLLKVGCTCVKPIVHQAA
uniprot
proteins
function
FUNCTION: Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:18025225, PubMed:19144317, PubMed:23255360). IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:15477493, PubMed:17911633, PubMed:18025225). IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation (PubMed:18025225, PubMed:23255360). As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (PubMed:18025225). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed:19144317). IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:28813677). Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (PubMed:28813677). Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (PubMed:32076265). Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes (PubMed:29915298). {ECO:0000250|UniProtKB:Q96PD4, ECO:0000269|PubMed:15477493, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18025225, ECO:0000269|PubMed:19144317, ECO:0000269|PubMed:23255360, ECO:0000269|PubMed:28813677, ECO:0000269|PubMed:29915298, ECO:0000269|PubMed:32076265}.
uniprot
proteins
mass_dalton
17941
uniprot
proteins
protein_family
IL-17 family
uniprot
proteins
pubmed
15477493
uniprot
proteins
pubmed
16990136
uniprot
proteins
pubmed
17911633
uniprot
proteins
pubmed
18025225
uniprot
proteins
pubmed
19144317
uniprot
proteins
pubmed
23255360
uniprot
proteins
pubmed
28813677
uniprot
proteins
pubmed
29915298
uniprot
proteins
pubmed
32076265
uniprot
proteins
sequence_length
161
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18025225}.
uniprot
proteins