PAPSS1
entrez
9061
canonical
uniprot
O43252
canonical
ensembl
ENSG00000138801
resolver
ensp
ENSP00000265174
resolver
enst
ENST00000265174
resolver
genesymbol
PAPSS1
resolver
genesymbol_syn
ATPSK1
resolver
genesymbol_syn
PAPSS
resolver
hgnc
HGNC:8603
resolver
uniprot
O43841
resolver
uniprot
O75332
resolver
uniprot
Q6IAX6
resolver
uniprot
Q96FB1
resolver
uniprot
Q96TF4
resolver
uniprot
Q9P1P9
resolver
uniprot
Q9UE98
resolver
uniprot_entry
PAPS1_HUMAN
resolver
uniprot_sec
O43841
resolver
uniprot_sec
O75332
resolver
uniprot_sec
Q6IAX6
resolver
uniprot_sec
Q96FB1
resolver
uniprot_sec
Q96TF4
resolver
uniprot_sec
Q9P1P9
resolver
uniprot_sec
Q9UE98
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by chlorate (PubMed:9576487). The kinase activity is subject to inhibition by the substrate adenylyl sulfate (PubMed:17540769). {ECO:0000269|PubMed:17540769, ECO:0000269|PubMed:9576487}.
uniprot
proteins
amino_acid_sequence
MEIPGSLCKKVKLSNNAQNWGMQRATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVPVDASYEVKELYVPENKLHLAKTDAETLPALKINKVDMQWVQVLAEGWATPLNGFMREREYLQCLHFDCLLDGGVINLSVPIVLTATHEDKERLDGCTAFALMYEGRRVAILRNPEFFEHRKEERCARQWGTTCKNHPYIKMVMEQGDWLIGGDLQVLDRVYWNDGLDQYRLTPTELKQKFKDMNADAVFAFQLRNPVHNGHALLMQDTHKQLLERGYRRPVLLLHPLGGWTKDDDVPLMWRMKQHAAVLEEGVLNPETTVVAIFPSPMMYAGPTEVQWHCRARMVAGANFYIVGRDPAGMPHPETGKDLYEPSHGAKVLTMAPGLITLEIVPFRVAAYNKKKKRMDYYDSEHHEDFEFISGTRMRKLAREGQKPPEGFMAPKAWTVLTEYYKSLEKA
uniprot
proteins
ec_number
2.7.1.25
uniprot
proteins
ec_number
2.7.7.4
uniprot
proteins
function
FUNCTION: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:14747722, PubMed:9576487, PubMed:9648242, PubMed:9668121). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487). {ECO:0000269|PubMed:14747722, ECO:0000269|PubMed:9576487, ECO:0000269|PubMed:9648242, ECO:0000269|PubMed:9668121}.
uniprot
proteins
mass_dalton
70833
uniprot
proteins
mutagenesis
MUTAGEN 37; /note="R->A: Abolishes inhibition by the substrate adenylyl sulfate."; /evidence="ECO:0000269|PubMed:17540769"; MUTAGEN 40; /note="R->A: Abolishes inhibition by the substrate adenylyl sulfate."; /evidence="ECO:0000269|PubMed:17540769"; MUTAGEN 425; /note="H->A: Loss of activity."; /evidence="ECO:0000269|PubMed:9915785"; MUTAGEN 426; /note="N->K: Increased activity."; /evidence="ECO:0000269|PubMed:9915785"; MUTAGEN 427..428; /note="GH->AA: Loss of activity."; MUTAGEN 427; /note="G->A: 30% decrease in activity."; /evidence="ECO:0000269|PubMed:9915785"; MUTAGEN 428; /note="H->A: Loss of activity."; /evidence="ECO:0000269|PubMed:9915785
uniprot
proteins
pathway_participation
PATHWAY: Sulfur metabolism; sulfate assimilation. {ECO:0000269|PubMed:14747722, ECO:0000269|PubMed:9576487, ECO:0000269|PubMed:9648242, ECO:0000269|PubMed:9668121}.
uniprot
proteins
protein_family
APS kinase family; Sulfate adenylyltransferase family
uniprot
proteins
pubmed
10679223
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14747722
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15755455
uniprot
proteins
pubmed
17276460
uniprot
proteins
pubmed
17540769
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
9576487
uniprot
proteins
pubmed
9648242
uniprot
proteins
pubmed
9668121
uniprot
proteins
pubmed
9915785
uniprot
proteins
sequence_length
624
uniprot
proteins