Cadm1
entrez
363058
canonical
uniprot
Q6AYP5
canonical
ensembl
ENSRNOG00000018778
resolver
ensembl
ENSRNOG00055019005
resolver
ensembl
ENSRNOG00060014493
resolver
ensembl
ENSRNOG00065023910
resolver
ensp
ENSRNOP00000041169
resolver
ensp
ENSRNOP00000069217
resolver
ensp
ENSRNOP00000076752
resolver
enst
ENSRNOT00000052392
resolver
enst
ENSRNOT00000079797
resolver
genesymbol
Cadm1
resolver
genesymbol_syn
SynCam1
resolver
uniprot
A0A0G2JUT1
resolver
uniprot
A0A5H1ZRU4
resolver
uniprot
F7EYW4
resolver
uniprot
Q0WXX6
resolver
uniprot_entry
A0A0G2JUT1_RAT
resolver
uniprot_entry
A0A5H1ZRU4_RAT
resolver
uniprot_entry
CADM1_RAT
resolver
uniprot_sec
F7EYW4
resolver
uniprot_sec
Q0WXX6
resolver
amino_acid_sequence
MASPVLPSGSQCAAAAAVAAAAAPPGLRLRLLLLLLSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNKELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVQIQMTYPLQGLTREGDAFELTCEATGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNTVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTTTILTIITDTTATTEPAVHGLTQLPNSAEELDSEDLSDSRAGEEGAIGAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI
uniprot
proteins
function
FUNCTION: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (By similarity). In mast cells, may mediate attachment to and promote communication with nerves (By similarity). CADM1, together with MITF, is essential for development and survival of mast cells in vivo. By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node. Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells. Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity). {ECO:0000250|UniProtKB:Q8R5M8, ECO:0000250|UniProtKB:Q9BY67}.
uniprot
proteins
mass_dalton
51854
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q8R5M8}.; PTM: Glycosylation at Asn-70 and Asn-104 promotes adhesive binding and synapse induction. {ECO:0000250|UniProtKB:Q8R5M8}.
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16814249
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
27756895
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8R5M8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8R5M8}. Synapse {ECO:0000250|UniProtKB:Q8R5M8}. Postsynaptic cell membrane {ECO:0000269|PubMed:27756895}. Note=Localized to the basolateral plasma membrane of epithelial cells in gall bladder. {ECO:0000250|UniProtKB:Q8R5M8}.
uniprot
proteins
transmembrane_region
TRANSMEM 409..429; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins