Cpt1c
entrez
78070
canonical
uniprot
Q8BGD5
canonical
ensembl
ENSMUSG00000007783
resolver
ensp
ENSMUSP00000069539
resolver
ensp
ENSMUSP00000148815
resolver
enst
ENSMUST00000063761
resolver
enst
ENSMUST00000212836
resolver
genesymbol
Cpt1c
resolver
uniprot
Q6NZF8
resolver
uniprot
Q8C071
resolver
uniprot_entry
CPT1C_MOUSE
resolver
uniprot_sec
Q6NZF8
resolver
uniprot_sec
Q8C071
resolver
amino_acid_sequence
MAEAHQASSLLSSLSSDGAEVELSSPVWQEIYLCALRSWKRHLWRVWNDFLAGVVPATPLSWLFLFSTIQLACLLQLDPSLGLMEKIKELLPDWGGQHHQLQGFLSAAVFASCLWGALIFTLHVALRLLLSHHGWLLEPHGAMSSPTKTWLALVRIFSGRHPRLFSFQRALPRQPVPSAQETVRKYLESVRPVLGDDAFDRATALANDFLRLHAPRLQLYLQLKSWCTSNYVSDWWEEFVYLRSRGSLINSTYYMMDFLYVTPTPLQAARAGNAVHTLLLYRHLLNRQEISPTLLMGMRPLCSAQYERMFNTTRIPGVEKDHLRHLQDSRHVAVFHRGRFFRVGTHSPNGLLSPRALEQQFQDILDDPSPACPLEEHLAALTAAPRSMWAQVRESVKTHAATALEAVEGAAFFVSLDSEPAGLTREDPAASLDAYAHALLAGRGHDRWFDKSFTLIVFSNGKLGLSVEHSWADCPVSGHLWEFTLATECFQLGYATDGHCKGHPDPTLPQPQRLQWDLPEQIQPSISLALRGAKTLSGNIDCHVFPFSHFGKSFIKCCHVSSDSFIQLVLQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREACQFVRAMDNKETDQHCLALFRVAVDKHQALLKAAMSGQGIDRHLFALYIMSRLLHMQSPFLTQVQSQQWLLSTSQVPVQQTHLIDVHNYPDYVSSGGGFGPAHDHGYGISYIFMGENAITFHISSKKSSTETDSHRLGQHIENALLDVASLFRVGQHFKRQFRGENSDYRYNFLSCKTVDPNTPTSSTNL
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
function
FUNCTION: Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1 (By similarity). Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner (PubMed:32931550). Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control (PubMed:16651524, PubMed:22539351, PubMed:37309891). Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels (PubMed:12376098, PubMed:25751282, PubMed:30135643). {ECO:0000250|UniProtKB:Q8TCG5, ECO:0000269|PubMed:12376098, ECO:0000269|PubMed:16651524, ECO:0000269|PubMed:22539351, ECO:0000269|PubMed:25751282, ECO:0000269|PubMed:30135643, ECO:0000269|PubMed:32931550, ECO:0000269|PubMed:37309891}.
uniprot
proteins
mass_dalton
90030
uniprot
proteins
mutagenesis
MUTAGEN 589; /note="M->S: Loss of binding to malonyl-CoA. Loss of regulation of SACM1L phosphatidylinositol-3-phosphatase activity. No effect on interaction with GRIA1."; /evidence="ECO:0000269|PubMed:32931550
uniprot
proteins
protein_family
Carnitine/choline acetyltransferase family
uniprot
proteins
pubmed
12376098
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16651524
uniprot
proteins
pubmed
18192268
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22539351
uniprot
proteins
pubmed
22632720
uniprot
proteins
pubmed
25751282
uniprot
proteins
pubmed
30135643
uniprot
proteins
pubmed
32931550
uniprot
proteins
pubmed
37309891
uniprot
proteins
sequence_length
798
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000305|PubMed:22632720}. Cell projection, axon {ECO:0000269|PubMed:25751282}. Cell projection, dendrite {ECO:0000269|PubMed:22539351, ECO:0000269|PubMed:25751282}. Cell projection, dendritic spine {ECO:0000269|PubMed:22539351}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22539351, ECO:0000269|PubMed:25751282}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in the soma and dendritic and axonal projections. {ECO:0000269|PubMed:25751282}.
uniprot
proteins
transmembrane_region
TRANSMEM 53..75; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..126; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins