Rnf123
entrez
84585
canonical
uniprot
Q5XPI3
canonical
ensembl
ENSMUSG00000041528
resolver
ensp
ENSMUSP00000125495
resolver
ensp
ENSMUSP00000125745
resolver
ensp
ENSMUSP00000275313
resolver
ensp
ENSMUSP00000275318
resolver
ensp
ENSMUSP00000275380
resolver
genesymbol
Rnf123
resolver
genesymbol_syn
Kpc1
resolver
uniprot
Q6PGE0
resolver
uniprot_entry
RN123_MOUSE
resolver
uniprot_sec
Q6PGE0
resolver
amino_acid_sequence
MASKGTGMSFSRKSYRLTSDAEKSRVTGIVQEKLLSDYLYRIFSPPDRGPAAATSRKPLNFHNLPEHVDQLLQVDSEDNESQGQVEGRLGPSTVVLDHTGGFEGLLLVDDDLLGVIGHSNFGTIRSTTCVYKGKWVYEVLISSQGLMQIGWCTINCRFNQEEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSLGTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGFRPLQDPPFADLVRAQRLLGCFQAVLSVELDPVEGRLVETESSEWQLQGQPTVLLTLAHIFHHFAPLLRKVYLVEAVLMSFLLGVVEKGTPEQAQSVVHQILDLLWLFMEDYEVQDCLKQLMMSLLRLYRFSPIVPDLGLQIHYLRLTMSILRHEKSRKFLLSNVLFDMLRSVVFFYIKSPLRVEEAGLKELIPTTWWPHRSSRESRDGKEAREETTEERQRRRAYERGCQRLKKRIEVVEELQVQILKLLLDNKDDNGGEASRYIFLTKFRKFLQENASGRGNTPVLCPPEYMVCFLHRLVSALRFYWDEYKASNPRASFSEEAYIPPQIFYNGKVDYFDLQRLGGLLSHLRKTLKDDLASKANIVIDPLELQAATMDDLDEDEEPAPSAAQRPMQALAIGGALPLPRPGWLSSPTLGRANRFLSTAAVSLMTPRRLLSTMEKVKVRSLNVEQRTREDIEGSHWNEGLLLGRPPEEPEQPLTENSLLEVLDGTVMMYNLSVHQQLGKMVGVSDDVNEYAMALRDTEDKLRRCPKRRKDILAELTKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLRTIEHGDRTGSLFAFMPEFYLSVAINSYSALKNYFGPVHSMEELPGYEETLTRLAAILAKHFADPRIVGTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQTNWILVRLWRGCGFGYRYTRLPHLLKTKPEDANLPSLQKPCPSTLLQQHMADLLRQGSDVAPSFLNSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLLRVLEMTITLVPEIFLDWSRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGLESVDHYPILVAVTGILVRLLVHGPTSETEQATSVLLADPCFQLRSICYLLGQPEPLAPGTTLPAPDRKRFSLQSYTDYISAEELAQVEQMLAHLTAASAQAAAASLPTNEEDLCPICYAHPISAVFQPCGHKSCKACINQHLMNNKDCFFCKATIVSVEDWDKAANTSAMSSAA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B: acts by catalyzing ubiquitination of the NFKB1 p105 precursor, leading to limited proteasomal degradation of NFKB1 p105 and generation of the active NFKB1 p50 subunit. Functions also as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS. {ECO:0000250|UniProtKB:Q5XPI4}.
uniprot
proteins
mass_dalton
148652
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q5XPI4}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation. Deubiquitinated by USP19, thereby stimulating CDKN1B ubiquitin-dependent degradation. {ECO:0000250|UniProtKB:D3ZXK7}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15531880
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
1314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5XPI4}.
uniprot
proteins