Setd5
entrez
72895
canonical
uniprot
Q5XJV7
canonical
ensembl
ENSMUSG00000034269
resolver
ensp
ENSMUSP00000047398
resolver
ensp
ENSMUSP00000108780
resolver
ensp
ENSMUSP00000108782
resolver
ensp
ENSMUSP00000177681
resolver
genesymbol
Setd5
resolver
genesymbol_syn
Kiaa1757
resolver
uniprot
Q80T94
resolver
uniprot
Q8BKD5
resolver
uniprot
Q8BX30
resolver
uniprot_entry
SETD5_MOUSE
resolver
uniprot_sec
Q80T94
resolver
uniprot_sec
Q8BKD5
resolver
uniprot_sec
Q8BX30
resolver
amino_acid_sequence
MSIAIPLGVTTPDTSYSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQRHGCRGLPYATIIPRSDLNGLPSPVEERCGDSPNSEGETVPTWCPCGLSQDGFLLNCDKCRGMSRGKVIRLHRRKQDNISGGDSSATESWDEELSPSTVLYTATQHTPTSITLTVRRTKPKKRKKSPEKGRAAPKTKKIKNSPSEAQNLDENTTEGWENRIRLWTDQYEEAFTNQYSADVQNALEQHLHSNKEFVGKPAILDTINKTELACNNTVIGSQMQLQLGRVTRVQKHRKILRAARDLALDTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQKRNPNAAELPLPPPPSFPTIGAETRRRKARRKELELEQQNEVPEENPDPQPQEVPEKVTVSNEHEEVDNPEEKPEEEEKEEATDDQENSAHSRRTREDRKVEAIMHAFESLEKRKKRRDQPVEQSSSDIEITTSSSEIVVGEETKTAAPESEVSSPVSNVAIPSTPQSTGVNTRRSSHAGDVAAEKPIPKPPPAKPSRPRPKSRISRYRTSSAQRLKRQKQAIAQQAELSQAALEEGGSNNSVTPPEAGNTDSSGENRQLTGSDPTVISVTGSHVNRAASKYPKTKKYLVTEWLNDKAEKQECPVECPLRITTDPTVLATTLNMLPGLIHSPLICTTPKHYIRFGSPFMPERRRRPLLPDGTFSSCKKRWIKQALEEGMTQTSSVPQETRTQHLYQSNETSNSSSICKDNADLLSPLKKWKSRYLMEQNITKLLQPLSPVTPPPPSSGSKSPQLTTPGQTHPGEEECRNGYSLMFSPITSLTTASRSNTPLQFELCHRKDLDLTKVGFPDSSTHSCADRPSLLNCNHPDLASHPSVVPTSEAGFPSRSGDGPQTLLRNSDQAFRTEFNLMYAYSPLNAMPRADGLYRGSPLVGDRKPLHLDGGYCSPAEGFSSRYEHGFMKDLSRGSMSPGGERTCEGVPSAPQNPPQRKKVSLLEYRKRKQEAKENSGGGNDSSQSKSKSSGAGQGSSNSVSDTGAHGVQGSSAGTPSSPHKKFSPSHSSASHLEAVSPSDSRGTSSSHCRPQENISSRWMVPTSVERLREGGSIPKVLRSSVRVAQKGEPSPTWESNITEKESDPADGEGPEPLSSALSKGATVYSPSRYSYQLLQCDSPRTESQSLLQQSSSPFRGHPTQSPGYSYRTTALRPGNPPSHGSSESSLSSTSYPSPAHPVSTDSLAPFTGTPGYYSSQPHSGNSTGSNLPRRSCSSSAASPTPQGPSDSPTSDSVSQSSTGTLSSTSFPQNSRSSLPSDLRTISLPNAGQSAAYQASRVSAVSNSQHYPHRGSGGVHQYRLQPLQGSGVKTQTGLS
uniprot
proteins
ec_number
2.1.1.359
uniprot
proteins
ec_number
2.1.1.367
uniprot
proteins
function
FUNCTION: Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission (PubMed:30455454, PubMed:31515109). May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics (PubMed:31515109). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (PubMed:22939622). The relevance of histone methyltransferase activity is however subject to discussion (PubMed:27864380, PubMed:30455454). {ECO:0000269|PubMed:22939622, ECO:0000269|PubMed:27864380, ECO:0000269|PubMed:30455454, ECO:0000269|PubMed:31515109}.
uniprot
proteins
mass_dalton
157426
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22939622
uniprot
proteins
pubmed
27864380
uniprot
proteins
pubmed
30455454
uniprot
proteins
pubmed
30655503
uniprot
proteins
pubmed
31515109
uniprot
proteins
sequence_length
1441
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27864380}. Chromosome {ECO:0000269|PubMed:31515109}. Note=Localizes to active transcribed genes. {ECO:0000269|PubMed:31515109}.
uniprot
proteins