BIN2
entrez
51411
canonical
uniprot
Q9UBW5
canonical
ensembl
ENSG00000110934
resolver
ensp
ENSP00000410217
resolver
ensp
ENSP00000445874
resolver
ensp
ENSP00000483983
resolver
ensp
ENSP00000541211
resolver
ensp
ENSP00000541213
resolver
ensp
ENSP00000541214
resolver
genesymbol
BIN2
resolver
genesymbol_syn
BRAP1
resolver
hgnc
HGNC:1053
resolver
uniprot
B7Z6F3
resolver
uniprot
F5H0W4
resolver
uniprot
Q86VV0
resolver
uniprot
Q9NWK4
resolver
uniprot
Q9UKN4
resolver
uniprot_entry
BIN2_HUMAN
resolver
uniprot_sec
B7Z6F3
resolver
uniprot_sec
F5H0W4
resolver
uniprot_sec
Q86VV0
resolver
uniprot_sec
Q9NWK4
resolver
uniprot_sec
Q9UKN4
resolver
amino_acid_sequence
MAEGKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLADQAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNKAQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLTAPEPQEEVSTSENPQL
uniprot
proteins
function
FUNCTION: Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}.
uniprot
proteins
mass_dalton
61874
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="F->A: Strongly reduces binding to membranes."; /evidence="ECO:0000269|PubMed:23285027"; MUTAGEN 21; /note="F->A: Strongly reduces binding to membranes."; /evidence="ECO:0000269|PubMed:23285027"; MUTAGEN 81; /note="V->R: Abolishes dimerization and membrane binding; when associated with E-214."; /evidence="ECO:0000269|PubMed:23285027"; MUTAGEN 214; /note="S->E: Abolishes dimerization and membrane binding; when associated with R-81."; /evidence="ECO:0000269|PubMed:23285027
uniprot
proteins
pubmed
10903846
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23285027
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
565
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23285027}. Cell projection, podosome membrane {ECO:0000269|PubMed:23285027}; Peripheral membrane protein {ECO:0000269|PubMed:23285027}; Cytoplasmic side {ECO:0000269|PubMed:23285027}. Cytoplasm, cell cortex {ECO:0000269|PubMed:23285027}. Cell projection, phagocytic cup {ECO:0000269|PubMed:23285027}. Note=Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure. {ECO:0000269|PubMed:23285027}.
uniprot
proteins