Timeless
entrez
21853
canonical
uniprot
Q9R1X4
canonical
ensembl
ENSMUSG00000039994
resolver
ensp
ENSMUSP00000058021
resolver
ensp
ENSMUSP00000100876
resolver
ensp
ENSMUSP00000100878
resolver
ensp
ENSMUSP00000100879
resolver
genesymbol
Timeless
resolver
genesymbol_syn
Tim1
resolver
genesymbol_syn
Timeless1
resolver
uniprot
Q3U574
resolver
uniprot
Q63ZX9
resolver
uniprot
Q6P204
resolver
uniprot
Q6PDL4
resolver
uniprot
Q7TPV8
resolver
uniprot
Q8R0Q2
resolver
uniprot
Q9R268
resolver
uniprot
Q9Z0E7
resolver
uniprot_entry
Q3U574_MOUSE
resolver
uniprot_entry
TIM_MOUSE
resolver
uniprot_sec
Q63ZX9
resolver
uniprot_sec
Q6P204
resolver
uniprot_sec
Q6PDL4
resolver
uniprot_sec
Q7TPV8
resolver
uniprot_sec
Q8R0Q2
resolver
uniprot_sec
Q9R268
resolver
uniprot_sec
Q9Z0E7
resolver
amino_acid_sequence
MDLYMMNCELLATCSALGYLEGGTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDLLPILTQHRQDKPLFDAVIRLMVNLTQPALLCFGSVPKDSSVRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEDRQEEDNLLIERILLLVRNILHVPANLEQEKSIDDDASIHDRLLWAIHLSGMDDLLLFLSSSSAEQQWSLHVLEIISLMFRDQTPEQLAGVGQGRLAQERSTDVAELEVLRQREMAEKRARALQRGNRHSRFGGSYIVQGLKSIGEKDVVFHKGLHNLQNYSSDLGKQPRRVPKRRQAAQELSVHRRSVLNVRLFLRDFCSEFLENCYNPLMGAVKDHLLRERAQQHDETYYMWAMAFFMAFNRAATFRPGLVSETLSIRTFHFVEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEMDMCPDEAVRESSRIIKNNIFYMMEYRELFLALFRKFDERYHPRSFLRDLVETTHLFLKMLERFCRSRGNLMVQNKRKKRKKKKKVQDQGVAFSQSPGELEAMWPALAEQLLQCAQDPELSVDPVVPFDAASEVPVEEQRVEAMVRIQDCLTAGQAPQALALLRSAREVWPEGNAFGSPVISPGEEMQLLKQILSTPLPRQQEPEEGDAEEEEEEEEEEELQVVQVSEKEFNFLEYLKRFASSTIVRAYVLLLRSYRQNSAHTNHCIAKMLHRLAHGLGMEALLFQLSLFCLFNRLLSDPAAAAYKELVTFAKYIIGKFFALAAVNQKAFVELLFWKNTAVVREMTQGYGSLDSGSSSHRAPLWSPEEEAQLQELYLAHKDVEGQDVVETILAHLKVVPRTRKQVIHHLVRMGLADSVKEFQKRKGTQIVLWTEDQELELQRLFEEFRDSDDVLGQIMKNITAKRSRARVVDKLLALGLVSERRQLYKKRRKKLAPSCMQNGEKSPRDPWQEDPEEEDEHLPEDESEDEESEEGLPSGQGQGSSSLSAENLGESLRQEGLSAPLLWLQSSLIRAANDREEDGCSQAIPLVPLTEENEEAMENEQFQHLLRKLGIRPPSSGQETFWRIPAKLSSTQLRRVAASLSQQENEEEREEEPEPGVPGEQGPSEEHRTEALRALLSARKRKAGLGPTEEEATGEEEWNSAPKKRQLLDSDEEEDDEGRRQAVSGTPRVHRKKRFQIEDEDD
uniprot
proteins
function
FUNCTION: Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:10428031, PubMed:12875843, PubMed:23418588, PubMed:31138685, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:12875843). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (By similarity). TIMELESS promotes TIPIN nuclear localization (PubMed:12875843, PubMed:31138685). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX11 (By similarity). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:12875843). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (By similarity). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:23418588). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:10428031, PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:9856465). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (PubMed:10963667). {ECO:0000250|UniProtKB:Q9UNS1, ECO:0000269|PubMed:10428031, ECO:0000269|PubMed:10963667, ECO:0000269|PubMed:12875843, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:31138685, ECO:0000269|PubMed:9856465}.
uniprot
proteins
mass_dalton
137503
uniprot
proteins
protein_family
Timeless family
uniprot
proteins
pubmed
10231394
uniprot
proteins
pubmed
10428031
uniprot
proteins
pubmed
10963667
uniprot
proteins
pubmed
12875843
uniprot
proteins
pubmed
14564007
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23418588
uniprot
proteins
pubmed
24489120
uniprot
proteins
pubmed
31138685
uniprot
proteins
pubmed
9856465
uniprot
proteins
pubmed
9856466
uniprot
proteins
pubmed
9891984
uniprot
proteins
sequence_length
1197
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10231394, ECO:0000269|PubMed:10428031, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:24489120}. Chromosome {ECO:0000250|UniProtKB:Q9UNS1}. Note=In response to double-strand breaks (DSBs), accumulates at DNA damage sites via its interaction with PARP1. {ECO:0000250|UniProtKB:Q9UNS1}.
uniprot
proteins