ACOT8
entrez
10005
canonical
uniprot
O14734
canonical
ensembl
ENSG00000101473
resolver
ensp
ENSP00000217455
resolver
ensp
ENSP00000435581
resolver
ensp
ENSP00000498636
resolver
ensp
ENSP00000654514
resolver
enst
ENST00000217455
resolver
enst
ENST00000461272
resolver
enst
ENST00000652771
resolver
genesymbol
ACOT8
resolver
genesymbol_syn
ACTEIII
resolver
genesymbol_syn
PTE1
resolver
hgnc
HGNC:15919
resolver
uniprot
A0A494C0N6
resolver
uniprot
E9PJN0
resolver
uniprot
O15261
resolver
uniprot
Q17RX4
resolver
uniprot_entry
A0A494C0N6_HUMAN
resolver
uniprot_entry
ACOT8_HUMAN
resolver
uniprot_entry
E9PJN0_HUMAN
resolver
uniprot_sec
O15261
resolver
uniprot_sec
Q17RX4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by CoASH (IC(50)=10-15 uM). Also inhibited by cysteine-reactive agents. {ECO:0000250|UniProtKB:P58137}.
uniprot
proteins
amino_acid_sequence
MSSPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRGRHYWVPAKRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRAGDPKLPVLYQVERTRTGSSFSVRSVKAVQHGKPIFICQASFQQAQPSPMQHQFSMPTVPPPEELLDCETLIDQYLRDPNLQKRYPLALNRIAAQEVPIEIKPVNPSPLSQLQRMEPKQMFWVRARGYIGEGDMKMHCCVAAYISDYAFLGTALLPHQWQHKVHFMVSLDHSMWFHAPFRADHWMLYECESPWAGGSRGLVHGRLWRQDGVLAVTCAQEGVIRVKPQVSESKL
uniprot
proteins
ec_number
3.1.2.1
uniprot
proteins
ec_number
3.1.2.11
uniprot
proteins
ec_number
3.1.2.2
uniprot
proteins
ec_number
3.1.2.27
uniprot
proteins
ec_number
3.1.2.3
uniprot
proteins
ec_number
3.1.2.5
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:15194431, PubMed:9153233, PubMed:9299485). Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (By similarity). Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains (PubMed:9153233, PubMed:9299485). Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (By similarity). Is also able to hydrolyze CoA esters of dicarboxylic acids (By similarity). It is involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431). {ECO:0000250|UniProtKB:P58137, ECO:0000269|PubMed:15194431, ECO:0000269|PubMed:9153233, ECO:0000269|PubMed:9299485}.; FUNCTION: (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed:9153233). {ECO:0000269|PubMed:9153233}.
uniprot
proteins
mass_dalton
35914
uniprot
proteins
mutagenesis
MUTAGEN 78; /note="H->A: Reduces Acyl-CoA thioesterase activity and peroxisome proliferation."; /evidence="ECO:0000269|PubMed:15194431
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000305|PubMed:10944470, ECO:0000305|PubMed:9299485}.
uniprot
proteins
protein_family
C/M/P thioester hydrolase family
uniprot
proteins
pubmed
10092594
uniprot
proteins
pubmed
10944470
uniprot
proteins
pubmed
11755680
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
15194431
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9153233
uniprot
proteins
pubmed
9299485
uniprot
proteins
sequence_length
319
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000269|PubMed:10092594, ECO:0000269|PubMed:15194431}. Note=Predominantly localized in the peroxisome but a localization to the cytosol cannot be excluded. {ECO:0000269|PubMed:10092594, ECO:0000269|PubMed:15194431}.
uniprot
proteins