Mapk10
entrez
25272
canonical
uniprot
P49187
canonical
ensembl
ENSRNOG00000002079
resolver
ensp
ENSRNOP00000060904
resolver
ensp
ENSRNOP00000075755
resolver
ensp
ENSRNOP00000075846
resolver
enst
ENSRNOT00000065965
resolver
enst
ENSRNOT00000092395
resolver
enst
ENSRNOT00000092719
resolver
genesymbol
Mapk10
resolver
genesymbol_syn
Jnk3
resolver
genesymbol_syn
Prkm10
resolver
uniprot
A0A0U1RRP0
resolver
uniprot
A0A0U1RVI2
resolver
uniprot
A0A8L2RB61
resolver
uniprot
B0VXR6
resolver
uniprot
D3ZQ33
resolver
uniprot_entry
A0A0U1RRP0_RAT
resolver
uniprot_entry
A0A0U1RVI2_RAT
resolver
uniprot_entry
A0A8L2RB61_RAT
resolver
uniprot_entry
MK10_RAT
resolver
uniprot_sec
B0VXR6
resolver
uniprot_sec
D3ZQ33
resolver
activity_regulation
ACTIVITY REGULATION: Activated by threonine and tyrosine phosphorylation by two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K7 phosphorylates MAPK10 on Thr-221 causing a conformational change and a large increase in Vmax for the enzyme. MAP2K4 then phosphorylates Tyr-223 resulting in a further increase in Vmax. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by HDAC9 (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MSLHFLYYCSEPTLDVKIAFCQGFDKHVDVSSVVKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
uniprot
proteins
ec_number
2.7.11.24
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Also participates in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (By similarity). {ECO:0000250|UniProtKB:Q61831, ECO:0000269|PubMed:12424734, ECO:0000269|PubMed:15944381}.
uniprot
proteins
mass_dalton
52532
uniprot
proteins
post_translational_modification
PTM: Dually phosphorylated on Thr-221 and Tyr-223 by MAP2K4 and MAP2K7, which activates the enzyme. MAP2K7 shows a strong preference for Thr-221 while MAP2K4 phosphorylates Tyr-223 preferentially. Weakly autophosphorylated on threonine and tyrosine residues in vitro (By similarity). {ECO:0000250}.; PTM: Palmitoylation regulates subcellular location and axonal development. {ECO:0000250}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MAP kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11090355
uniprot
proteins
pubmed
12424734
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15944381
uniprot
proteins
pubmed
18408005
uniprot
proteins
pubmed
21076496
uniprot
proteins
pubmed
8177321
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Membrane; Lipid-anchor. Nucleus. Mitochondrion. Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1. {ECO:0000250}.
uniprot
proteins