CCL2
entrez
6347
canonical
uniprot
P13500
canonical
ensembl
ENSG00000108691
resolver
ensp
ENSP00000225831
resolver
enst
ENST00000225831
resolver
genesymbol
CCL2
resolver
genesymbol_syn
MCP1
resolver
genesymbol_syn
SCYA2
resolver
hgnc
HGNC:10618
resolver
uniprot
B2R4V3
resolver
uniprot
Q9UDF3
resolver
uniprot_entry
CCL2_HUMAN
resolver
uniprot_sec
B2R4V3
resolver
uniprot_sec
Q9UDF3
resolver
amino_acid_sequence
MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT
uniprot
proteins
function
FUNCTION: Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:10529171, PubMed:10587439, PubMed:9837883). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:10587439, PubMed:9837883). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8195247, PubMed:8627182, PubMed:9792674). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690). {ECO:0000269|PubMed:10529171, ECO:0000269|PubMed:10587439, ECO:0000269|PubMed:8107690, ECO:0000269|PubMed:8195247, ECO:0000269|PubMed:8627182, ECO:0000269|PubMed:9792674, ECO:0000269|PubMed:9837883}.
uniprot
proteins
mass_dalton
11025
uniprot
proteins
mutagenesis
MUTAGEN 24..91; /note="Missing: 83% reduction in activity."; MUTAGEN 24..85; /note="Missing: 90% reduction in activity."; MUTAGEN 24; /note="Missing: Loss of activity."; MUTAGEN 25..31; /note="Missing: Loss of signaling."; /evidence="ECO:0000269|PubMed:10587439"; MUTAGEN 26; /note="D->A: Reduction in activity."; /evidence="ECO:0000269|PubMed:10587439"; MUTAGEN 28; /note="I->A: Slight reduction in activity."; /evidence="ECO:0000269|PubMed:10587439"; MUTAGEN 29; /note="N->A: 50% reduction in activity."; /evidence="ECO:0000269|PubMed:10587439"; MUTAGEN 31; /note="P->A: Loss of dimerization; slight reduction of activity."; /evidence="ECO:0000269|PubMed:10587439, ECO:0000269|PubMed:9837883"; MUTAGEN 32; /note="V->A: Slight reduction in activity."; /evidence="ECO:0000269|PubMed:10587439, ECO:0000269|PubMed:9837883"; MUTAGEN 32; /note="V->E: Slight reduction in affinity."; /evidence="ECO:0000269|PubMed:10587439, ECO:0000269|PubMed:9837883"; MUTAGEN 33; /note="T->A: Slight reduction in activity."; /evidence="ECO:0000269|PubMed:10587439, ECO:0000269|PubMed:9837883"; MUTAGEN 33; /note="T->E: Slight reduction in affinity."; /evidence="ECO:0000269|PubMed:10587439, ECO:0000269|PubMed:9837883"; MUTAGEN 36; /note="Y->A: Loss of activity."; /evidence="ECO:0000269|PubMed:9837883"; MUTAGEN 41..42; /note="RK->AA: Abolishes binding to Link domain of TNFAIP6."; /evidence="ECO:0000269|PubMed:27044744"; MUTAGEN 47; /note="R->F: 95% reduction in activity; strong reduction of receptor binding."; MUTAGEN 50; /note="S->Q: 40% reduction in activity."; MUTAGEN 51; /note="Y->D: Loss of activity."; MUTAGEN 53; /note="R->L: Loss of activity."; MUTAGEN 79; /note="K->A: No effect on heparin binding."; MUTAGEN 81; /note="K->A: Strongly reduces heparin binding."; /evidence="ECO:0000269|PubMed:9792674"; MUTAGEN 89; /note="H->A: Strongly reduces heparin binding."; /evidence="ECO:0000269|PubMed:9792674"; MUTAGEN 91; /note="D->L: 90% reduction in activity."; MUTAGEN 95..99; /note="Missing: No effect on heparin binding."; /evidence="ECO:0000269|PubMed:9792674
uniprot
proteins
post_translational_modification
PTM: Processing at the N-terminus can regulate receptor and target cell selectivity (PubMed:8627182). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (PubMed:8627182). {ECO:0000269|PubMed:8627182}.; PTM: N-Glycosylated. {ECO:0000269|PubMed:2513477}.
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
10529171
uniprot
proteins
pubmed
10587439
uniprot
proteins
pubmed
10918580
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15033992
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16352737
uniprot
proteins
pubmed
1661560
uniprot
proteins
pubmed
1857712
uniprot
proteins
pubmed
2071154
uniprot
proteins
pubmed
2322286
uniprot
proteins
pubmed
23233732
uniprot
proteins
pubmed
2357211
uniprot
proteins
pubmed
23765988
uniprot
proteins
pubmed
23955712
uniprot
proteins
pubmed
2465924
uniprot
proteins
pubmed
2513477
uniprot
proteins
pubmed
2518726
uniprot
proteins
pubmed
2648385
uniprot
proteins
pubmed
27044744
uniprot
proteins
pubmed
2923622
uniprot
proteins
pubmed
30568593
uniprot
proteins
pubmed
34831181
uniprot
proteins
pubmed
8107690
uniprot
proteins
pubmed
8195247
uniprot
proteins
pubmed
8627182
uniprot
proteins
pubmed
8639605
uniprot
proteins
pubmed
8898111
uniprot
proteins
pubmed
8989326
uniprot
proteins
pubmed
9792674
uniprot
proteins
pubmed
9837883
uniprot
proteins
sequence_length
99
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23955712, ECO:0000269|PubMed:2513477}.
uniprot
proteins