CYCS
entrez
54205
canonical
uniprot
P99999
canonical
ensembl
ENSG00000172115
resolver
ensp
ENSP00000307786
resolver
ensp
ENSP00000386270
resolver
ensp
ENSP00000387279
resolver
ensp
ENSP00000547283
resolver
ensp
ENSP00000547284
resolver
ensp
ENSP00000547285
resolver
ensp
ENSP00000547286
resolver
ensp
ENSP00000582076
resolver
ensp
ENSP00000582077
resolver
enst
ENST00000305786
resolver
enst
ENST00000409409
resolver
enst
ENST00000409764
resolver
enst
ENST00000877224
resolver
enst
ENST00000877225
resolver
enst
ENST00000877226
resolver
enst
ENST00000877227
resolver
enst
ENST00000912017
resolver
enst
ENST00000912018
resolver
genesymbol
CYCS
resolver
genesymbol_syn
CYC
resolver
hgnc
HGNC:19986
resolver
uniprot
A4D166
resolver
uniprot
B2R4I1
resolver
uniprot
G4XXL9
resolver
uniprot
P00001
resolver
uniprot
Q6NUR2
resolver
uniprot
Q6NX69
resolver
uniprot
Q96BV4
resolver
uniprot_entry
CYC_HUMAN
resolver
uniprot_entry
G4XXL9_HUMAN
resolver
uniprot_sec
A4D166
resolver
uniprot_sec
B2R4I1
resolver
uniprot_sec
P00001
resolver
uniprot_sec
Q6NUR2
resolver
uniprot_sec
Q6NX69
resolver
uniprot_sec
Q96BV4
resolver
amino_acid_sequence
MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGIIWGEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE
uniprot
proteins
disease_involvement
DISEASE: Thrombocytopenia 4 (THC4) [MIM:612004]: A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. {ECO:0000269|PubMed:18345000}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.; FUNCTION: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
uniprot
proteins
mass_dalton
11749
uniprot
proteins
mutagenesis
MUTAGEN 6; /note="K->A,D,R: No effect on covalent heme attachment."; /evidence="ECO:0000269|PubMed:23150584"; MUTAGEN 11; /note="F->A: Decreased covalent heme attachment."; /evidence="ECO:0000269|PubMed:23150584"; MUTAGEN 11; /note="F->Y: No effect on covalent heme attachment."; /evidence="ECO:0000269|PubMed:23150584"; MUTAGEN 15; /note="C->S: Decreased covalent heme attachment."; /evidence="ECO:0000269|PubMed:23150584"; MUTAGEN 18; /note="C->A: Decreased covalent heme attachment."; /evidence="ECO:0000269|PubMed:23150584"; MUTAGEN 19; /note="H->A: Loss of covalent heme attachment."; /evidence="ECO:0000269|PubMed:23150584
uniprot
proteins
post_translational_modification
PTM: Binds 1 heme c group covalently per subunit.; PTM: Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration. {ECO:0000250}.
uniprot
proteins
protein_family
Cytochrome c family
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
13933734
uniprot
proteins
pubmed
14063298
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18345000
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23150584
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2849112
uniprot
proteins
pubmed
9515723
uniprot
proteins
sequence_length
105
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
uniprot
proteins