Atp6v1d
entrez
73834
canonical
uniprot
P57746
canonical
ensembl
ENSMUSG00000021114
resolver
ensp
ENSMUSP00000021536
resolver
ensp
ENSMUSP00000290373
resolver
enst
ENSMUST00000021536
resolver
genesymbol
Atp6v1d
resolver
genesymbol_syn
Atp6m
resolver
genesymbol_syn
Vatd
resolver
uniprot
Q3U861
resolver
uniprot_entry
Q3U861_MOUSE
resolver
uniprot_entry
VATD_MOUSE
resolver
amino_acid_sequence
MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKIIKEKFEKDLERRRAAGEVMEPANLLAEEKDEDLLFE
uniprot
proteins
function
FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). {ECO:0000250|UniProtKB:P39942, ECO:0000250|UniProtKB:Q9Y5K8}.
uniprot
proteins
mass_dalton
28369
uniprot
proteins
protein_family
V-ATPase D subunit family
uniprot
proteins
pubmed
11435709
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9Y5K8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Y5K8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Y5K8}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P39942}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Y5K8}. Lysosome membrane {ECO:0000250|UniProtKB:Q9Y5K8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Y5K8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9Y5K8}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9Y5K8}. Note=Localizes to centrosome and the base of the cilium. {ECO:0000250|UniProtKB:Q9Y5K8}.
uniprot
proteins