DERL2
entrez
51009
canonical
uniprot
Q9GZP9
canonical
ensembl
ENSG00000072849
resolver
ensp
ENSP00000158771
resolver
ensp
ENSP00000460671
resolver
ensp
ENSP00000559637
resolver
ensp
ENSP00000654416
resolver
enst
ENST00000158771
resolver
enst
ENST00000572834
resolver
genesymbol
DERL2
resolver
genesymbol_syn
DER2
resolver
genesymbol_syn
FLANA
resolver
hgnc
HGNC:17943
resolver
uniprot
I3L3R8
resolver
uniprot
Q9Y3A7
resolver
uniprot_entry
DERL2_HUMAN
resolver
uniprot_entry
I3L3R8_HUMAN
resolver
uniprot_sec
Q9Y3A7
resolver
amino_acid_sequence
MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITNFLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFLGQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGHIYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
uniprot
proteins
function
FUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins (PubMed:16186509, PubMed:16449189). May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). {ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:16449189, ECO:0000269|PubMed:26565908}.; FUNCTION: (Microbial infection) In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. {ECO:0000269|PubMed:15215855}.
uniprot
proteins
mass_dalton
27567
uniprot
proteins
protein_family
Derlin family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11500051
uniprot
proteins
pubmed
15215855
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16186509
uniprot
proteins
pubmed
16449189
uniprot
proteins
pubmed
19084021
uniprot
proteins
pubmed
22016385
uniprot
proteins
pubmed
26565908
uniprot
proteins
sequence_length
239
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}; Multi-pass membrane protein {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..78; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 97..117; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 151..171; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical; Name=4"; /evidence="ECO:0000255
uniprot
proteins