Gjb2
entrez
14619
canonical
uniprot
Q00977
canonical
ensembl
ENSMUSG00000046352
resolver
ensp
ENSMUSP00000054343
resolver
enst
ENSMUST00000055698
resolver
genesymbol
Gjb2
resolver
genesymbol_syn
Cxn-26
resolver
uniprot
Q3UJE9
resolver
uniprot_entry
CXB2_MOUSE
resolver
uniprot_entry
Q3UJE9_MOUSE
resolver
amino_acid_sequence
MDWGTLQSILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGCKNVCYDHHFPISHIRLWALQLIMVSTPALLVAMHVAYRRHEKKRKFMKGEIKNEFKDIEEIKTQKVRIEGSLWWTYTTSIFFRVIFEAVFMYVFYIMYNGFFMQRLVKCNAWPCPNTVDCFISRPTEKTVFTVFMISVSGICILLNITELCYLFVRYCSGKSKRPV
uniprot
proteins
function
FUNCTION: Structural component of gap junctions (PubMed:15692151). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:15692151). {ECO:0000250|UniProtKB:P29033, ECO:0000269|PubMed:15692151}.
uniprot
proteins
mass_dalton
26411
uniprot
proteins
protein_family
Beta-type (group I) subfamily
uniprot
proteins
protein_family
Connexin family
uniprot
proteins
pubmed
1322820
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15692151
uniprot
proteins
pubmed
19864490
uniprot
proteins
pubmed
2060697
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15692151, ECO:0000269|PubMed:19864490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P29033}. Cell junction, gap junction {ECO:0000269|PubMed:15692151, ECO:0000269|PubMed:19864490}. Note=Colocalizes with GJB4 at gap junction plaques in the cochlea. {ECO:0000269|PubMed:15692151}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..40; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P29033"; TRANSMEM 74..94; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P29033"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P29033"; TRANSMEM 190..210; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P29033
uniprot
proteins