Tafa5
entrez
500915
canonical
uniprot
M0R7X9
canonical
ensembl
ENSRNOG00000049349
resolver
ensembl
ENSRNOG00055032526
resolver
ensembl
ENSRNOG00060029974
resolver
ensembl
ENSRNOG00065033438
resolver
ensp
ENSRNOP00000102712
resolver
ensp
ENSRNOP00055046355
resolver
ensp
ENSRNOP00060043310
resolver
ensp
ENSRNOP00065047330
resolver
enst
ENSRNOT00000135490
resolver
enst
ENSRNOT00055056202
resolver
enst
ENSRNOT00060052074
resolver
enst
ENSRNOT00065057489
resolver
genesymbol
Tafa5
resolver
genesymbol_syn
Fam19a5
resolver
uniprot
A0ABK0LIE4
resolver
uniprot_entry
A0ABK0LIE4_RAT
resolver
uniprot_entry
TAFA5_RAT
resolver
amino_acid_sequence
MAPSPRTSSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDARIIKTKQWCDMLPCLEGEGCDLLINRSGWTCTQPGGRIKTTTVS
uniprot
proteins
function
FUNCTION: Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (PubMed:29453251). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated through the GPCR FPR2 (By similarity). Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (PubMed:29453251). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (PubMed:29453251). {ECO:0000250|UniProtKB:Q91WE9, ECO:0000269|PubMed:29453251}.
uniprot
proteins
mass_dalton
14331
uniprot
proteins
protein_family
TAFA family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
18275939
uniprot
proteins
pubmed
29453251
uniprot
proteins
sequence_length
132
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29453251}.
uniprot
proteins