Ddx56
entrez
52513
canonical
uniprot
Q9D0R4
canonical
ensembl
ENSMUSG00000004393
resolver
ensp
ENSMUSP00000004507
resolver
ensp
ENSMUSP00000299669
resolver
enst
ENSMUST00000004507
resolver
genesymbol
Ddx56
resolver
genesymbol_syn
D11Ertd619e
resolver
genesymbol_syn
Noh61
resolver
uniprot
Q5SVX3
resolver
uniprot_entry
DDX56_MOUSE
resolver
uniprot_entry
Q5SVX3_MOUSE
resolver
amino_acid_sequence
MEDQEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQSLLHKKATGPVMEQAVRGLVLVPTKELARQAQAMIQQLAAYCARDVRVANVSAAEDSASQRAVLMEKPDVVVGTPSRVLSHLQQNTLKLRDSLELLVVDEADLLFSFGFEDELKSLLCHLPRIYQAFLMSATFNEDVQTLKELVLHNPVTLKLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKALLFVNTLERGYRLRLFLEQFSIPSCVLNGELPLRSRCHIISQFNQGLYDCVIATDAEILGPQVKGKRRGRGSKGNKASDPESGVARGIDFHHVSAVLNFDLPPTAEAYVHRAGRTARANNPGIVLTFVLPAEQPFLGKIEDLLSGEGEAPILLPYQFQMEEIESFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGHVPDYLVPAALRGLVHPRKKRRKVPFSRKAKKVKAQNPLRDFKHRGKKPKPAAKPS
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization. Plays an essential role in maintaining nucleolar integrity in planarian stem cells (PubMed:32703285). Maintains embryonic stem cells proliferation by conventional regulation of ribosome assembly and interaction with OCT4 and POU5F1 complex (PubMed:32703285). Regulates antiviral innate immunity by inhibiting the virus-triggered signaling nuclear translocation of IRF3. Mechanistically, acts by disrupting the interaction between IRF3 and importin IPO5. May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (By similarity). {ECO:0000250|UniProtKB:Q9NY93, ECO:0000269|PubMed:32703285}.
uniprot
proteins
mass_dalton
61212
uniprot
proteins
protein_family
DDX56/DBP9 subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
32703285
uniprot
proteins
sequence_length
546
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:32703285}.
uniprot
proteins