Dach2
entrez
93837
canonical
uniprot
Q925Q8
canonical
ensembl
ENSMUSG00000025592
resolver
ensp
ENSMUSP00000064393
resolver
ensp
ENSMUSP00000109005
resolver
ensp
ENSMUSP00000109006
resolver
ensp
ENSMUSP00000109007
resolver
ensp
ENSMUSP00000109009
resolver
ensp
ENSMUSP00000286441
resolver
enst
ENSMUST00000113378
resolver
enst
ENSMUST00000113379
resolver
genesymbol
Dach2
resolver
uniprot
B1AU60
resolver
uniprot
B1AXA6
resolver
uniprot
Q8BMA0
resolver
uniprot_entry
B1AU60_MOUSE
resolver
uniprot_entry
B1AXA6_MOUSE
resolver
uniprot_entry
DACH2_MOUSE
resolver
uniprot_sec
Q8BMA0
resolver
amino_acid_sequence
MAVSAPPVISATSSSAGVPGGLFRAEPLYSSPGEPPRLTPNMINSFMANNHNGSVLGGGIGGGSGGSSNTNTNECRMVDMHGVKVASFLMDGQELICLPQVFDLFLKHLVGGLHTVYTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNARRKRQMTRKQAVNSSRPGRPPKRSLGVLQDNARLLPHAVPGLLSPGLITPTGITAAAMAEAMKLQKMKLMAMNTLQGNGSQNGTESEPDDLNSTTGGSESSWDKDKIQSPLAASGPQHGIAHAALAGQPGLGGAPTLNPLQQNHLLSNRLDLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAAQIHSPLSRAGASVIKERIPESPSPAPSLEESHRPGSQTSSHPSSSVSSSPSQMDHHSERMVMMPNNREELIVDQDNGQSIKKFQRDNKEEVPAQIPVMKSPLDKIQLAPGQALHPGFPGPFIFADSLSSVETLLTNIQGLLKVALDNARIQEKQIQQEKKELRIELFREREIRENLERQLAVELQSRSTMQKRLKKEKKAKRKLQEALEFESKRREQVEQALKQATSGDSGLRMLKDSGIPDIEIENSGTPHDSAAMQGGNYYCLAMAQQLCSA
uniprot
proteins
function
FUNCTION: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression also seems to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression. Probably binds to DNA via its DACHbox-N domain. {ECO:0000269|PubMed:12112464, ECO:0000269|PubMed:12130660}.
uniprot
proteins
mass_dalton
68588
uniprot
proteins
protein_family
DACH/dachshund family
uniprot
proteins
pubmed
11287190
uniprot
proteins
pubmed
12112464
uniprot
proteins
pubmed
12130660
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
634
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins