ICAM2
entrez
3384
canonical
uniprot
P13598
canonical
ensembl
ENSG00000108622
resolver
ensp
ENSP00000388666
resolver
ensp
ENSP00000392634
resolver
ensp
ENSP00000415283
resolver
ensp
ENSP00000462579
resolver
ensp
ENSP00000464665
resolver
ensp
ENSP00000523017
resolver
ensp
ENSP00000635173
resolver
ensp
ENSP00000635174
resolver
ensp
ENSP00000635175
resolver
enst
ENST00000412356
resolver
enst
ENST00000418105
resolver
enst
ENST00000449662
resolver
enst
ENST00000579687
resolver
enst
ENST00000579788
resolver
enst
ENST00000852958
resolver
enst
ENST00000965114
resolver
enst
ENST00000965115
resolver
enst
ENST00000965116
resolver
genesymbol
ICAM2
resolver
hgnc
HGNC:5345
resolver
uniprot
Q14600
resolver
uniprot
Q6FHE2
resolver
uniprot_entry
ICAM2_HUMAN
resolver
uniprot_entry
Q6FHE2_HUMAN
resolver
uniprot_sec
Q14600
resolver
amino_acid_sequence
MSSFGYRTLTVALFTLICCPGSDEKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGLETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLLSLFVTSVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP
uniprot
proteins
function
FUNCTION: Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion on resting cells (PubMed:10077629, PubMed:1676048, PubMed:2497351). Also endothelial blood vessels receptor ligand of dendritic cell (DC) CD209 signaling receptor that mediates triggering transendothelial migration of DC presursors from blood into peripheral tissues and, subsequently, into lymphoid tissues (PubMed:11017109). Mediates adhesive interactions important for antigen presentation, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (Probable). {ECO:0000269|PubMed:10077629, ECO:0000269|PubMed:11017109, ECO:0000269|PubMed:1676048, ECO:0000269|PubMed:2497351, ECO:0000305|PubMed:1676048}.
uniprot
proteins
mass_dalton
30654
uniprot
proteins
protein_family
ICAM family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
10077629
uniprot
proteins
pubmed
11017109
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
1676048
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19892738
uniprot
proteins
pubmed
2497351
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9153399
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1676048}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, microvillus {ECO:0000250|UniProtKB:P35330}. Note=Co-localizes with RDX, EZR and MSN in microvilli. {ECO:0000250|UniProtKB:P35330}.
uniprot
proteins
transmembrane_region
TRANSMEM 224..248; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins