Slc8a2
entrez
140447
canonical
uniprot
P48768
canonical
ensembl
ENSRNOG00000001492
resolver
ensp
ENSRNOP00000042012
resolver
ensp
ENSRNOP00000071086
resolver
ensp
ENSRNOP00000104936
resolver
enst
ENSRNOT00000047289
resolver
enst
ENSRNOT00000086396
resolver
genesymbol
Slc8a2
resolver
genesymbol_syn
Ncx2
resolver
uniprot
A0A0G2JZK7
resolver
uniprot
F1M9A2
resolver
uniprot_entry
A0A0G2JZK7_RAT
resolver
uniprot_entry
F1M9A2_RAT
resolver
uniprot_entry
NAC2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Calcium transport is down-regulated by Na(+) and stimulated by Ca(2+). {ECO:0000269|PubMed:8021246, ECO:0000269|PubMed:9486131}.
uniprot
proteins
amino_acid_sequence
MAPLALVGVALLLGAPHCLGEATPTPSLPPPPANDSDASPGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGLSIIADRFMASIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCVYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGTEVPGELGALGTGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADAARRPGANDGAPDDEDDGASRIFFEPSLYHCLENCGSVLLSVACQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEAQRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAVTVSAGDEEEDEDGSREERLPSCFDYVMHFLTVFWKVLFACLPPTEYCHGWACFGVCILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFLGLWFLYILFASLEAYCHIRGF
uniprot
proteins
function
FUNCTION: Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:8021246, PubMed:9486131). Contributes to cellular Ca(2+) homeostasis in excitable cells (By similarity). Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Plays a role in regulating urinary Ca(2+) and Na(+) excretion (By similarity). {ECO:0000250|UniProtKB:Q8K596, ECO:0000269|PubMed:8021246, ECO:0000269|PubMed:9486131}.
uniprot
proteins
mass_dalton
100523
uniprot
proteins
protein_family
Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family
uniprot
proteins
protein_family
SLC8 subfamily
uniprot
proteins
pubmed
16914199
uniprot
proteins
pubmed
23506867
uniprot
proteins
pubmed
8021246
uniprot
proteins
pubmed
8798769
uniprot
proteins
pubmed
9486131
uniprot
proteins
sequence_length
921
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16914199, ECO:0000269|PubMed:8021246, ECO:0000269|PubMed:9486131}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8K596}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K596}. Perikaryon {ECO:0000269|PubMed:16914199}. Cell projection, dendrite {ECO:0000269|PubMed:16914199}. Cell projection, dendritic spine {ECO:0000269|PubMed:16914199}.
uniprot
proteins
transmembrane_region
TRANSMEM 69..90; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 131..152; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 197..219; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 223..246; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 721..740; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 748..770; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 773..791; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 823..843; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 855..875; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 893..909; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins