Ace2
entrez
70008
canonical
uniprot
Q8R0I0
canonical
ensembl
ENSMUSG00000015405
resolver
ensp
ENSMUSP00000073626
resolver
ensp
ENSMUSP00000107890
resolver
genesymbol
Ace2
resolver
uniprot
Q3URC9
resolver
uniprot
Q99N70
resolver
uniprot
Q99N71
resolver
uniprot_entry
ACE2_MOUSE
resolver
uniprot_entry
Q3URC9_MOUSE
resolver
uniprot_sec
Q99N70
resolver
uniprot_sec
Q99N71
resolver
amino_acid_sequence
MSSSSWLLLSLVAVTTAQSLTEENAKTFLNNFNQEAEDLSYQSSLASWNYNTNITEENAQKMSEAAAKWSAFYEEQSKTAQSFSLQEIQTPIIKRQLQALQQSGSSALSADKNKQLNTILNTMSTIYSTGKVCNPKNPQECLLLEPGLDEIMATSTDYNSRLWAWEGWRAEVGKQLRPLYEEYVVLKNEMARANNYNDYGDYWRGDYEAEGADGYNYNRNQLIEDVERTFAEIKPLYEHLHAYVRRKLMDTYPSYISPTGCLPAHLLGDMWGRFWTNLYPLTVPFAQKPNIDVTDAMMNQGWDAERIFQEAEKFFVSVGLPHMTQGFWANSMLTEPADGRKVVCHPTAWDLGHGDFRIKMCTKVTMDNFLTAHHEMGHIQYDMAYARQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLPSDFQEDSETEINFLLKQALTIVGTLPFTYMLEKWRWMVFRGEIPKEQWMKKWWEMKREIVGVVEPLPHDETYCDPASLFHVSNDYSFIRYYTRTIYQFQFQEALCQAAKYNGSLHKCDISNSTEAGQKLLKMLSLGNSEPWTKALENVVGARNMDVKPLLNYFQPLFDWLKEQNRNSFVGWNTEWSPYADQSIKVRISLKSALGANAYEWTNNEMFLFRSSVAYAMRKYFSIIKNQTVPFLEEDVRVSDLKPRVSFYFFVTSPQNVSDVIPRSEVEDAIRMSRGRINDVFGLNDNSLEFLGIHPTLEPPYQPPVTIWLIIFGVVMALVVVGIIILIVTGIKGRKKKNETKREENPYDSMDIGKGESNAGFQNSDDAQTSF
uniprot
proteins
ec_number
3.4.17.-
uniprot
proteins
ec_number
3.4.17.23
uniprot
proteins
function
FUNCTION: Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A (By similarity). By cleavage of angiotensin II, may be an important regulator of heart function (PubMed:12075344, PubMed:12967627). By cleavage of angiotensin II, may also have a protective role in acute lung injury (PubMed:16001071). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19, regulating its trafficking on the cell surface and its activity (PubMed:18424768, PubMed:19185582, PubMed:22677001). {ECO:0000250|UniProtKB:Q9BYF1, ECO:0000269|PubMed:12075344, ECO:0000269|PubMed:12967627, ECO:0000269|PubMed:16001071, ECO:0000269|PubMed:18424768, ECO:0000269|PubMed:19185582, ECO:0000269|PubMed:22677001}.
uniprot
proteins
mass_dalton
92368
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1 (By similarity). {ECO:0000250}.; PTM: Phosphorylated. Phosphorylation at Tyr-781 probably inhibits interaction with AP2M1 and enables interactions with proteins containing SH2 domains. {ECO:0000250|UniProtKB:Q9BYF1}.; PTM: Ubiquitinated. Ubiquitinated on Lys-788 via 'Lys-48'-linked ubiquitin. 'Lys-48'-linked deubiquitinated by USP50 on the Lys-788; leading to its stabilization. {ECO:0000250|UniProtKB:Q9BYF1}.
uniprot
proteins
protein_family
Peptidase M2 family
uniprot
proteins
pubmed
12075344
uniprot
proteins
pubmed
12487024
uniprot
proteins
pubmed
12967627
uniprot
proteins
pubmed
15452268
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15949646
uniprot
proteins
pubmed
16001071
uniprot
proteins
pubmed
18424768
uniprot
proteins
pubmed
19185582
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22677001
uniprot
proteins
pubmed
23535237
uniprot
proteins
pubmed
32425701
uniprot
proteins
sequence_length
805
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Processed angiotensin-converting enzyme 2]: Secreted {ECO:0000250}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23535237}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:23535237}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9BYF1}. Apical cell membrane {ECO:0000250|UniProtKB:Q9BYF1}. Note=Detected in both cell membrane and cytoplasm in neurons. {ECO:0000269|PubMed:23535237}.
uniprot
proteins
transmembrane_region
TRANSMEM 741..761; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01354
uniprot
proteins