Emc6
entrez
66048
canonical
uniprot
Q9CQW0
canonical
ensembl
ENSMUSG00000047260
resolver
ensp
ENSMUSP00000060892
resolver
ensp
ENSMUSP00000104120
resolver
enst
ENSMUST00000054952
resolver
enst
ENSMUST00000108480
resolver
genesymbol
Emc6
resolver
genesymbol_syn
Tmem93
resolver
uniprot
Q9CQ41
resolver
uniprot_entry
EMC6_MOUSE
resolver
uniprot_sec
Q9CQ41
resolver
amino_acid_sequence
MAAVVAKREGPPFISEAAVRGNAAVLDYCRTSVSALSGATAGILGLTGLYGFIFYLLASVLLSLLLILKAGRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. {ECO:0000250|UniProtKB:Q9BV81}.
uniprot
proteins
mass_dalton
12017
uniprot
proteins
protein_family
EMC6 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
110
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BV81}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BV81}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..44; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9BV81"; TRANSMEM 51..71; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9BV81"; TRANSMEM 90..106; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9BV81
uniprot
proteins