Slc17a7
entrez
72961
canonical
uniprot
Q3TXX4
canonical
ensembl
ENSMUSG00000070570
resolver
ensp
ENSMUSP00000082489
resolver
enst
ENSMUST00000085374
resolver
genesymbol
Slc17a7
resolver
genesymbol_syn
Bnpi
resolver
genesymbol_syn
Vglut1
resolver
uniprot
E9QMT8
resolver
uniprot
Q8JZR7
resolver
uniprot_entry
Q8JZR7_MOUSE
resolver
uniprot_entry
VGLU1_MOUSE
resolver
uniprot_sec
E9QMT8
resolver
activity_regulation
ACTIVITY REGULATION: Chloride channel activity is allosterically activated by lumenal H(+) and Cl(-) leading to synaptic vesicles acidification. The L-glutamate transport activity is allosterically activated by lumenal H(+) and Cl(-). The allosteric activation by H(+) efficiently prevents non-vesicular efflux across the plasma membrane, thereby restricting L-glutamate transport activity to acidic membranes such as synaptic vesicles. {ECO:0000250|UniProtKB:Q62634}.
uniprot
proteins
amino_acid_sequence
MEFRQEEFRKLAGRALGRLHRLLEKRQEGAETLELSADGRPVTTHTRDPPVVDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFNWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGESAKLMNPVTKFNTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRHIMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEPEEMSEEKCGFVGHDQLAGSDESEMEDEAEPPGAPPAPPPSYGATHSTVQPPRPPPPVRDY
uniprot
proteins
function
FUNCTION: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:25433636, PubMed:29273736, PubMed:29642010, PubMed:33440152). At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:15103023, PubMed:15118123, PubMed:25433636, PubMed:29642010). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:29642010). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (PubMed:25433636, PubMed:29273736, PubMed:29642010). Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity). The vesicular K(+)/H(+) antiport activity is electroneutral (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:29642010, PubMed:33440152). The symporter activity is driven by an inside negative membrane potential and is electrogenic (PubMed:29642010). Is necessary for synaptic signaling of visual-evoked responses from photoreceptors (PubMed:17611277). {ECO:0000250|UniProtKB:Q62634, ECO:0000269|PubMed:15103023, ECO:0000269|PubMed:15118123, ECO:0000269|PubMed:17611277, ECO:0000269|PubMed:25433636, ECO:0000269|PubMed:29273736, ECO:0000269|PubMed:29642010, ECO:0000269|PubMed:33440152}.
uniprot
proteins
mass_dalton
61637
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sodium/anion cotransporter family
uniprot
proteins
protein_family
VGLUT subfamily
uniprot
proteins
pubmed
12384506
uniprot
proteins
pubmed
15103023
uniprot
proteins
pubmed
15118123
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16595674
uniprot
proteins
pubmed
16942593
uniprot
proteins
pubmed
17611277
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24153177
uniprot
proteins
pubmed
25433636
uniprot
proteins
pubmed
29273736
uniprot
proteins
pubmed
29642010
uniprot
proteins
pubmed
33440152
uniprot
proteins
sequence_length
560
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:16942593}. Cell membrane {ECO:0000305|PubMed:29642010}; Multi-pass membrane protein {ECO:0000305}. Synapse, synaptosome {ECO:0000269|PubMed:16595674}.
uniprot
proteins
transmembrane_region
TRANSMEM 64..84; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 209..229; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 237..257; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 303..323; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 342..362; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 379..399; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 402..422; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 436..456; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins