Mogs
entrez
57377
canonical
uniprot
Q80UM7
canonical
ensembl
ENSMUSG00000030036
resolver
ensp
ENSMUSP00000032114
resolver
enst
ENSMUST00000032114
resolver
genesymbol
Mogs
resolver
genesymbol_syn
Gcs1
resolver
uniprot
Q9Z2W5
resolver
uniprot_entry
MOGS_MOUSE
resolver
uniprot_sec
Q9Z2W5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the deoxynojirimycin derivative N-9'-Methoxynonyl-1-Deoxynojirimycin. {ECO:0000269|PubMed:32227946}.
uniprot
proteins
amino_acid_sequence
MARGERRRRAAAAEGARPLERARAAGRRDGRAGGARGSASGAALAVVVLALAFGLSGRWVLAWLRVRRALTLHPAPSALPPDSSSPAVAPELFWGTYRPHVYFGMKTRSPKPLLTGLMWAQQGATPGTPPKLRHTCEQGDGVGPYGWEFHDGRTFGRQHIHDGALRLTTEFVKRPGGQHGGDWSWRVTVEPQASGTPSFPLVSLFFYVVTDGQEVLLPEIGAKGQLKSISGHTSELGDFRLTLLPPTSPGDTVPKHGSYNVFWSSNPGLPQLTDMVKSRLNSWFQHRPPGASPDRYLGLPGSLKWEERGPSGQGQFLIQQVTLKAPFSVEFVFESGSAATGGNQASGRLVGSQLTQALESHAAAFKERFEKTFQLKEKGLSPEEQALGQVALSGLLGGIGYFYGQGLVLPDTSMEGSEQKMDPALFPPVPLFSGVPSRSFFPRGFLWDEGFHQLVVQRWDPHLTREALGHWLGLLNADGWIGREQILGDEARARVPPEFLVQRAAHANPPTLLLPVVHMLEGHDPDDLAFLRKAFPRLHAWFSWLHQSQAGPVPLSYRWRGRDLALPTLLNPKTLPSGLDDYPRASHPSTAERHLDLRCWVALGARVLSQLAEQLGETEAAAELGPLAASLEEPGSLDELHWAPELGVFADFGNHTKAVQLKSRPPQGLVRVVGRPPPRLQYVDALGYVSLFPLLLQLLDPSSPRLGPLLDVLADSRHLWSPFGLRSLSASSLFYKQRNTEHDPPYWRGAVWLNINYLALGALHHYGHVEGPHKVQAAKLYHELRANVVRNVRQQYQATGFLWEQYSDQDGRGMGCRPFQGWTSLVLLIMAEEY
uniprot
proteins
ec_number
3.2.1.106
uniprot
proteins
function
FUNCTION: In the context of N-glycan degradation, cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner. {ECO:0000250|UniProtKB:Q13724}.; FUNCTION: (Microbial infection) Required for successful influenza or dengue virus infection; inhibition of its activity by a deoxynojirimycin derivative prevents death in mice infected with lethal doses of influenza or dengue viruses, even when administrated after infection. {ECO:0000269|PubMed:32227946}.
uniprot
proteins
mass_dalton
91831
uniprot
proteins
pathway_participation
PATHWAY: Glycan metabolism; N-glycan degradation. {ECO:0000250|UniProtKB:Q13724}.
uniprot
proteins
protein_family
Glycosyl hydrolase 63 family
uniprot
proteins
pubmed
10406845
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32227946
uniprot
proteins
sequence_length
834
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q13724}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O88941}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..64; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins