Gan
entrez
209239
canonical
uniprot
Q8CA72
canonical
ensembl
ENSMUSG00000052557
resolver
ensp
ENSMUSP00000070168
resolver
ensp
ENSMUSP00000124904
resolver
enst
ENSMUST00000064488
resolver
enst
ENSMUST00000162997
resolver
genesymbol
Gan
resolver
uniprot_entry
GAN_MOUSE
resolver
amino_acid_sequence
MAEGSAVSDPQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKECSNIPLSQPQQGEAMLASFKPRGYSECIVTIGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVLGGQDENKQTLSSGEKYDPDANTWTALPPMHEARHNFGIVEIDGMLYILGGEDGDRELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDIQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRIANCKLFRLQLQQGLFRIRVHSP
uniprot
proteins
function
FUNCTION: Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB (By similarity). Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival. {ECO:0000250, ECO:0000269|PubMed:16227972, ECO:0000269|PubMed:16565160}.
uniprot
proteins
mass_dalton
67671
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9H2C0}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. {ECO:0000250}.
uniprot
proteins
pubmed
12147674
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16227972
uniprot
proteins
pubmed
16565160
uniprot
proteins
pubmed
18680552
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
597
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12147674}.
uniprot
proteins