P0C1X8
uniprot
P0C1X8
canonical
activity_regulation
ACTIVITY REGULATION: Stimulated by clathrin. {ECO:0000250|UniProtKB:Q2M2I8}.
uniprot
proteins
amino_acid_sequence
MKKFFDSRREQGSSGLGSGSSGGGGSSSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFALVFLVRTSNGVKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQAEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGSFTIPDNSRYSQDMHCLIYMLEPDPDKRPDIYQVSYFSFKLLKKECPVPNVQNSPIPTKLPEPVKASEAAVKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPLPQATGPSNQPSLLASVSQPKAQATPSQPLQSSQPKQPQAPPTPQQTPAPQTQGLPTQAQATPQHQQQLLLKQQQQQQQQQQQQQPQQPTAPPQPSGTFYQQQQPQQQQAQTQQQFQAVHPAAQQSVTAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQLMAQQAALQQKTAVVVPQPQAQPATAPQAAAAQEPQIQAPARQQPKVQTTPPPTIQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLHAAAAEASLSKSKSATTTPSGSPRTSQQNVSNASEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKLPEKLGGSAESLIPGFQATQGDAFATSSFSAGTAEKRKGGQAVDSGIPLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADAAVESLIPGLEPPVAQRLPSHTESVTSNRTDSLTGEDSLLDCSLLSNPTADLLDEFAPIALSASTHKAAEDSNLISGFGVAEGSEKVAEDEFDPIPVLITKNTQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877461). Preferentially, may phosphorylate substrates on threonine residues (By similarity). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (By similarity). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (By similarity). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q2M2I8, ECO:0000269|PubMed:11877461}.
uniprot
proteins
mass_dalton
103761
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000250|UniProtKB:Q2M2I8}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
11877461
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
962
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:F1MH24}; Peripheral membrane protein {ECO:0000250|UniProtKB:F1MH24}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:11877461}. Presynapse {ECO:0000269|PubMed:11877461}. Note=Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells. {ECO:0000269|PubMed:11877461}.
uniprot
proteins