Q61826
uniprot
Q61826
canonical
amino_acid_sequence
MESILALLLALALVPYQLSRGQSFQVNPPESEVAVAMGTSLQITCSMSCDEGVARVHWRGLDTSLGSVQTLPGSSILSVRGMLSDTGTPVCVGSCGSRSFQHSVKILVYAFPDQLVVSPEFLVPGQDQVVSCTAHNIWPADPNSLSFALLLGEQRLEGAQALEPEQEEEIQEAEGTPLFRMTQRWRLPSLGTPAPPALHCQVTMQLPKLVLTHRKEIPVLQSQTSPKPPNTTSAEPYILTSSSTAEAVSTGLNITTLPSAPPYPKLSPRTLSSEGPCRPKIHQDLEAGWELLCEASCGPGVTVRWTLAPGDLATYHKREAGAQAWLSVLPPGPMVEGWFQCRQDPGGEVTNLYVPGQVTPNSSSTVVLWIGSLVLGLLALVFLAYRLWKCYRPGPRPDTSSCTHL
uniprot
proteins
disease_involvement
DISEASE: Note=Absence of Madcam1 in the spleen has been found in aly/aly mice, but normal expression is found in intestinal venules. This aberrant expression is a secondary defect and not the direct cause of aly alymphoplasia, an autosomal recessive mutation which induces total aplasia of lymph nodes and Peyer patches. {ECO:0000269|PubMed:9316640}.
uniprot
proteins
function
FUNCTION: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Both isoform 1 and isoform 2 can adhere to integrin alpha-4/beta-7. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding. {ECO:0000269|PubMed:3340147, ECO:0000269|PubMed:7488084}.
uniprot
proteins
mass_dalton
43652
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains syalic acid. The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation. {ECO:0000269|PubMed:7505053}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
3340147
uniprot
proteins
pubmed
7488084
uniprot
proteins
pubmed
7505053
uniprot
proteins
pubmed
7650378
uniprot
proteins
pubmed
7687523
uniprot
proteins
pubmed
7693764
uniprot
proteins
pubmed
7724598
uniprot
proteins
pubmed
8502297
uniprot
proteins
pubmed
9316640
uniprot
proteins
sequence_length
405
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 365..385; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins