IPO9
entrez
55705
canonical
uniprot
Q96P70
canonical
ensembl
ENSG00000198700
resolver
ensp
ENSP00000354742
resolver
enst
ENST00000361565
resolver
genesymbol
IPO9
resolver
genesymbol_syn
IMP9
resolver
genesymbol_syn
KIAA1192
resolver
genesymbol_syn
RANBP9
resolver
hgnc
HGNC:19425
resolver
uniprot
B1ASV5
resolver
uniprot
Q8N1Y1
resolver
uniprot
Q8N3I2
resolver
uniprot
Q8NCG9
resolver
uniprot
Q96SU6
resolver
uniprot
Q9NW01
resolver
uniprot
Q9P0A8
resolver
uniprot
Q9ULM8
resolver
uniprot_entry
IPO9_HUMAN
resolver
uniprot_sec
B1ASV5
resolver
uniprot_sec
Q8N1Y1
resolver
uniprot_sec
Q8N3I2
resolver
uniprot_sec
Q8NCG9
resolver
uniprot_sec
Q96SU6
resolver
uniprot_sec
Q9NW01
resolver
uniprot_sec
Q9P0A8
resolver
uniprot_sec
Q9ULM8
resolver
amino_acid_sequence
MAAAAAAGAASGLPGPVAQGLKEALVDTLTGILSPVQEVRAAAEEQIKVLEVTEEFGVHLAELTVDPQGALAIRQLASVILKQYVETHWCAQSEKFRPPETTERAKIVIRELLPNGLRESISKVRSSVAYAVSAIAHWDWPEAWPQLFNLLMEMLVSGDLNAVHGAMRVLTEFTREVTDTQMPLVAPVILPEMYKIFTMAEVYGIRTRSRAVEIFTTCAHMICNMEELEKGAAKVLIFPVVQQFTEAFVQALQIPDGPTSDSGFKMEVLKAVTALVKNFPKHMVSSMQQILPIVWNTLTESAAFYVRTEVNYTEEVEDPVDSDGEVLGFENLVFSIFEFVHALLENSKFKSTVKKALPELIYYIILYMQITEEQIKVWTANPQQFVEDEDDDTFSYTVRIAAQDLLLAVATDFQNESAAALAAAATRHLQEAEQTKNSGTEHWWKIHEACMLALGSVKAIITDSVKNGRIHFDMHGFLTNVILADLNLSVSPFLLGRALWAASRFTVAMSPELIQQFLQATVSGLHETQPPSVRISAVRAIWGYCDQLKVSESTHVLQPFLPSILDGLIHLAAQFSSEVLNLVMETLCIVCTVDPEFTASMESKICPFTIAIFLKYSNDPVVASLAQDIFKELSQIEACQGPMQMRLIPTLVSIMQAPADKIPAGLCATAIDILTTVVRNTKPPLSQLLICQAFPAVAQCTLHTDDNATMQNGGECLRAYVSVTLEQVAQWHDEQGHNGLWYVMQVVSQLLDPRTSEFTAAFVGRLVSTLISKAGRELGENLDQILRAILSKMQQAETLSVMQSLIMVFAHLVHTQLEPLLEFLCSLPGPTGKPALEFVMAEWTSRQHLFYGQYEGKVSSVALCKLLQHGINADDKRLQDIRVKGEEIYSMDEGIRTRSKSAKNPERWTNIPLLVKILKLIINELSNVMEANAARQATPAEWSQDDSNDMWEDQEEEEEEEEDGLAGQLLSDILATSKYEEDYYEDDEEDDPDALKDPLYQIDLQAYLTDFLCQFAQQPCYIMFSGHLNDNERRVLQTIGI
uniprot
proteins
function
FUNCTION: Nuclear transport receptor that mediates nuclear import of proteins, such as histones, proteasome and actin (PubMed:11823430, PubMed:30855230, PubMed:34711951). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the import of pre-assembled proteasomes into the nucleus; AKIRIN2 acts as a molecular bridge between IPO9 and the proteasome complex (PubMed:11823430, PubMed:34711951). Mediates the nuclear import of histones H2A, H2B, H4 and H4 (PubMed:11823430, PubMed:30855230). In addition to nuclear import, also acts as a chaperone for histones by preventing inappropriate non-nucleosomal interactions (PubMed:30855230). Mediates the nuclear import of actin (By similarity). {ECO:0000250|UniProtKB:Q91YE6, ECO:0000269|PubMed:11823430, ECO:0000269|PubMed:30855230, ECO:0000269|PubMed:34711951}.
uniprot
proteins
mass_dalton
115963
uniprot
proteins
protein_family
Importin beta family
uniprot
proteins
pubmed
10574461
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11823430
uniprot
proteins
pubmed
12670497
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30855230
uniprot
proteins
pubmed
34711951
uniprot
proteins
sequence_length
1041
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11823430}. Nucleus {ECO:0000269|PubMed:11823430}.
uniprot
proteins