NSMCE4A
entrez
54780
canonical
uniprot
Q9NXX6
canonical
ensembl
ENSG00000107672
resolver
ensp
ENSP00000358013
resolver
ensp
ENSP00000358019
resolver
ensp
ENSP00000539075
resolver
ensp
ENSP00000675863
resolver
genesymbol
NSMCE4A
resolver
genesymbol_syn
C10orf86
resolver
hgnc
HGNC:25935
resolver
uniprot
Q5SQQ5
resolver
uniprot
Q6P673
resolver
uniprot
Q8WY66
resolver
uniprot
Q9BS90
resolver
uniprot_entry
NSE4A_HUMAN
resolver
uniprot_sec
Q5SQQ5
resolver
uniprot_sec
Q6P673
resolver
uniprot_sec
Q8WY66
resolver
uniprot_sec
Q9BS90
resolver
amino_acid_sequence
MSGDSSGRGPEGRGRGRDPHRDRTRSRSRSRSPLSPRSRRGSARERREAPERPSLEDTEPSDSGDEMMDPASLEAEADQGLCRQIRHQYRALINSVQQNREDILNAGDKLTEVLEEANTLFNEVSRAREAVLDAHFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEELIRDEDSPDFEFIVYDSWKITGRTAENTFNKTHTFHFLLGSIYGECPVPKPRVDRPRKVPVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQTYFREDPDTPMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIEPVSINEENEGFEHNTQVRNQGIIALSYRDWEEIVKTFEISEPVITPSQRQQKPSA
uniprot
proteins
function
FUNCTION: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269|PubMed:18086888}.
uniprot
proteins
mass_dalton
44301
uniprot
proteins
protein_family
NSE4 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18086888
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27427983
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18086888}. Chromosome, telomere {ECO:0000305|PubMed:18086888}.
uniprot
proteins