Syne4
entrez
233066
canonical
uniprot
Q8CII8
canonical
ensembl
ENSMUSG00000019737
resolver
ensp
ENSMUSP00000055874
resolver
ensp
ENSMUSP00000135637
resolver
enst
ENSMUST00000054594
resolver
enst
ENSMUST00000176304
resolver
genesymbol
Syne4
resolver
genesymbol_syn
AI428936
resolver
uniprot
H3BL35
resolver
uniprot
Q6PH99
resolver
uniprot
Q99J42
resolver
uniprot_entry
H3BL35_MOUSE
resolver
uniprot_entry
SYNE4_MOUSE
resolver
uniprot_sec
Q6PH99
resolver
uniprot_sec
Q99J42
resolver
amino_acid_sequence
MALVPPLGREFPPEPVNCPLAAPRELDVVGGTICPAPEEETSRPEQVQASLGLPEHCMGELKSTESATSPSRLPLASSHEHQDGGKPCEHSDSGLEVLEAEQDSLHLCLLRLNFRLQDLERGLGSWTLAHNRIVQMQALQAELRGAAERVDALLAFGEGLAERSEPRAWASLEQVLRALGTHRDTIFQRLWQLQAQLISYSLVLEKANLLDQDLEVEGDSDGPAAGGVWGPWAPSTFPTPAELEWDPAGDVGGLGPSGQKISRIPGAPCELCGYRGPQSSGQGLEDLLSLGLGHRKHLAAHHRRRLRKPQDRKRQVSPSLPDAMLEVDRGVPAPASKRPLTLFFLLLFLLLVGATLLLPLSGVSCCSHARLARTPYLVLSYVNGLPPI
uniprot
proteins
function
FUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology, by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus. {ECO:0000250, ECO:0000269|PubMed:19164528}.
uniprot
proteins
mass_dalton
42024
uniprot
proteins
post_translational_modification
PTM: The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces. {ECO:0000250|UniProtKB:Q8WXH0}.
uniprot
proteins
protein_family
Nesprin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19164528
uniprot
proteins
pubmed
23348741
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000269|PubMed:19164528, ECO:0000269|PubMed:23348741}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19164528, ECO:0000269|PubMed:23348741}. Note=Localization at the nucleus outer membrane location requires the presence of SUN1.
uniprot
proteins
transmembrane_region
TRANSMEM 340..360; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00385
uniprot
proteins