ENPEP
entrez
2028
canonical
uniprot
Q07075
canonical
ensembl
ENSG00000138792
resolver
ensp
ENSP00000265162
resolver
ensp
ENSP00000546230
resolver
ensp
ENSP00000777391
resolver
enst
ENST00000265162
resolver
genesymbol
ENPEP
resolver
hgnc
HGNC:3355
resolver
uniprot
Q504U2
resolver
uniprot_entry
AMPE_HUMAN
resolver
uniprot_sec
Q504U2
resolver
activity_regulation
ACTIVITY REGULATION: Substrate specificity is modulated by calcium which enhances the enzymatic activity for cleavage of acidic residues while reducing its activity with basic residues. Inhibited by aminopeptidase inhibitors amastatin and bestatin. {ECO:0000269|PubMed:10692253, ECO:0000269|PubMed:23888046}.
uniprot
proteins
amino_acid_sequence
MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG
uniprot
proteins
ec_number
3.4.11.7
uniprot
proteins
function
FUNCTION: Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. {ECO:0000305|PubMed:23888046}.
uniprot
proteins
mass_dalton
109244
uniprot
proteins
mutagenesis
MUTAGEN 356; /note="T->V: Reduced enzyme activity."; /evidence="ECO:0000269|PubMed:23888046"; MUTAGEN 887; /note="R->A: Reduced enzyme activity."; /evidence="ECO:0000269|PubMed:23888046
uniprot
proteins
protein_family
Peptidase M1 family
uniprot
proteins
pubmed
10692253
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23888046
uniprot
proteins
pubmed
8244382
uniprot
proteins
pubmed
8346219
uniprot
proteins
sequence_length
957
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10692253}; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins