Atxn7l3
entrez
217218
canonical
uniprot
A2AWT3
canonical
ensembl
ENSMUSG00000059995
resolver
ensp
ENSMUSP00000072967
resolver
ensp
ENSMUSP00000102750
resolver
ensp
ENSMUSP00000121917
resolver
ensp
ENSMUSP00000299234
resolver
ensp
ENSMUSP00000299243
resolver
ensp
ENSMUSP00000299246
resolver
genesymbol
Atxn7l3
resolver
uniprot
A2AWT2
resolver
uniprot
A2AWT4
resolver
uniprot
Q8C1T7
resolver
uniprot_entry
AT7L3_MOUSE
resolver
uniprot_sec
A2AWT2
resolver
uniprot_sec
A2AWT4
resolver
uniprot_sec
Q8C1T7
resolver
amino_acid_sequence
MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN
uniprot
proteins
function
FUNCTION: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B. {ECO:0000255|HAMAP-Rule:MF_03047}.
uniprot
proteins
mass_dalton
38594
uniprot
proteins
protein_family
SGF11 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
347
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03047}.
uniprot
proteins