Sirt5
entrez
68346
canonical
uniprot
Q8K2C6
canonical
ensembl
ENSMUSG00000054021
resolver
ensp
ENSMUSP00000071048
resolver
ensp
ENSMUSP00000152526
resolver
ensp
ENSMUSP00000152796
resolver
ensp
ENSMUSP00000318474
resolver
ensp
ENSMUSP00000318477
resolver
ensp
ENSMUSP00000318480
resolver
enst
ENSMUST00000066804
resolver
enst
ENSMUST00000221515
resolver
enst
ENSMUST00000223194
resolver
genesymbol
Sirt5
resolver
genesymbol_syn
SIRT5
resolver
genesymbol_syn
Sir2l5
resolver
uniprot
A0A1Y7VM56
resolver
uniprot_entry
A0A1Y7VM56_MOUSE
resolver
uniprot_entry
SIR5_MOUSE
resolver
amino_acid_sequence
MRPLLIAPGRFISQLCCRRKPPASPQSKICLTMARPSSNMADFRKCFANAKHIAIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPQAFARNPSQVWEFYHYRREVMRSKEPNPGHLAIAQCEARLRDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCGTVAENYRSPICPALAGKGAPEPETQDARIPVDKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELALCDLCLVVGTSSVVYPAAMFAPQVASRGVPVAEFNMETTPATDRFRFHFPGPCGKTLPEALAPHETERTS
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
function
FUNCTION: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:23806337, PubMed:24315375, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:19410549, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (By similarity). Activates SHMT2 by mediating its desuccinylation (By similarity). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (PubMed:24315375). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox (PubMed:23085393). {ECO:0000255|HAMAP-Rule:MF_03160, ECO:0000269|PubMed:19410549, ECO:0000269|PubMed:21908771, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:23085393, ECO:0000269|PubMed:23806337, ECO:0000269|PubMed:24315375, ECO:0000269|PubMed:24703693}.
uniprot
proteins
mass_dalton
34134
uniprot
proteins
mutagenesis
MUTAGEN 158; /note="H->Y: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:19410549
uniprot
proteins
protein_family
Class III subfamily
uniprot
proteins
protein_family
Sirtuin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19410549
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21908771
uniprot
proteins
pubmed
22076378
uniprot
proteins
pubmed
23085393
uniprot
proteins
pubmed
23438705
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24076663
uniprot
proteins
pubmed
24315375
uniprot
proteins
pubmed
24703693
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus.
uniprot
proteins