Rab30
entrez
75985
canonical
uniprot
Q923S9
canonical
ensembl
ENSMUSG00000030643
resolver
ensp
ENSMUSP00000032879
resolver
ensp
ENSMUSP00000102798
resolver
ensp
ENSMUSP00000263793
resolver
ensp
ENSMUSP00000263799
resolver
enst
ENSMUST00000032879
resolver
enst
ENSMUST00000107180
resolver
genesymbol
Rab30
resolver
genesymbol_syn
Rsb30
resolver
uniprot
Q0PD24
resolver
uniprot
Q3UQR3
resolver
uniprot
Q9D3Q6
resolver
uniprot_entry
Q0PD24_MOUSE
resolver
uniprot_entry
RAB30_MOUSE
resolver
uniprot_sec
Q3UQR3
resolver
uniprot_sec
Q9D3Q6
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) including USP6NL, which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MSMEDYDFLFKIVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEINGEKVKLQIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYASNKVITVLVGNKIDLAERREVSQQRAEEFSEAQDMYYLETSAKESDNVEKLFLDLACRLISEARQNTLVNNVSSPLPGEGKSISYLTCCNFN
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:38796472). RAB30 is required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins (By similarity). Facilitates lipid homeostasis during fasting by regulating hepatic protein and lipid trafficking in a PPAR-alpha-dependent manner (PubMed:38796472). Promotes autophagosome biogenesis during bacterial infection such as group A Streptococcus infection (By similarity). {ECO:0000250|UniProtKB:Q15771, ECO:0000269|PubMed:38796472}.
uniprot
proteins
mass_dalton
23058
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
38796472
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q15771}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q15771}. Golgi apparatus membrane {ECO:0000269|PubMed:38796472}. Cytoplasm {ECO:0000250|UniProtKB:Q15771}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q15771}. Autolysosome membrane {ECO:0000250|UniProtKB:Q15771}. Note=Localized to dynamic membranes fusing to and exiting from the Golgi apparatus (PubMed:38796472). Localized to group A Streptococcus (GAS)-containing autophagosome to autolysosome in GAS-infected epithelial cells (By similarity). Also colocalized with a starvation-induced autophagosome although not required for autophagosome formation during starvation (By similarity). {ECO:0000250|UniProtKB:Q15771, ECO:0000269|PubMed:38796472}.
uniprot
proteins