Sdhb
entrez
298596
canonical
uniprot
P21913
canonical
ensembl
ENSRNOG00000007967
resolver
ensembl
ENSRNOG00060024101
resolver
ensp
ENSRNOP00000088032
resolver
ensp
ENSRNOP00060034624
resolver
enst
ENSRNOT00060041764
resolver
genesymbol
Sdhb
resolver
genesymbol_syn
Sdh1
resolver
uniprot
B0BMZ2
resolver
uniprot
Q0QEZ3
resolver
uniprot_entry
SDHB_RAT
resolver
uniprot_sec
B0BMZ2
resolver
uniprot_sec
Q0QEZ3
resolver
activity_regulation
ACTIVITY REGULATION: Enol-oxaloacetate inhibits the succinate dehydrogenase activity. {ECO:0000250|UniProtKB:Q3T189}.
uniprot
proteins
amino_acid_sequence
MAAVVGVSLKRGFSATALGRVGLQFQACREAQTAAAAAPRIKTFAIYRWDPDKAGDKPRMQTYKVDLNKCGPMVLDALIKIKNEIDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTDLGKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEDREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDEFTEERLAKLQDPFSLYRCHTIMNCTQTCPKGLNPGKAIAEIKKMMATYKEKRALA
uniprot
proteins
ec_number
1.1.5.-
uniprot
proteins
ec_number
1.3.5.1
uniprot
proteins
function
FUNCTION: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity). {ECO:0000250|UniProtKB:P21912, ECO:0000250|UniProtKB:Q3T189}.
uniprot
proteins
mass_dalton
31830
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
uniprot
proteins
protein_family
Succinate dehydrogenase/fumarate reductase iron-sulfur protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16751257
uniprot
proteins
pubmed
2494655
uniprot
proteins
sequence_length
282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9YHT2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9YHT2}; Matrix side {ECO:0000250|UniProtKB:Q9YHT2}.
uniprot
proteins