Slco2b1
entrez
101488
canonical
uniprot
Q8BXB6
canonical
ensembl
ENSMUSG00000030737
resolver
ensp
ENSMUSP00000032985
resolver
ensp
ENSMUSP00000102701
resolver
ensp
ENSMUSP00000102703
resolver
enst
ENSMUST00000032985
resolver
enst
ENSMUST00000107086
resolver
enst
ENSMUST00000107088
resolver
genesymbol
Slco2b1
resolver
genesymbol_syn
Oatp2b1
resolver
genesymbol_syn
Slc21a9
resolver
uniprot
F6ZMC5
resolver
uniprot
Q3TQJ3
resolver
uniprot
Q3V1K7
resolver
uniprot
Q8BLV8
resolver
uniprot_entry
F6ZMC5_MOUSE
resolver
uniprot_entry
Q3TQJ3_MOUSE
resolver
uniprot_entry
Q3V1K7_MOUSE
resolver
uniprot_entry
SO2B1_MOUSE
resolver
uniprot_sec
Q8BLV8
resolver
amino_acid_sequence
MPDRSTKTTMGTEDMHERKVSVEPQDSHQDAQPRGMFHNIKFFVLCHSLLQLTQLMISGYLKSSISTVEKRFGLSSQISGLLAAFNEVGNVSLILFVSYFGSRVHRPRMIGYGALLVATAGLLMALPHFISEPYRYDHSSSDNRSLDFEASLCLPTTMAPASALSNGSCSSHTETKHLTMVGIMFAAQTLLGIGGVPIQPFGISYIDDFAHHSNSPLYIGILFGITTMGPGLAYGLGSLMLRLYVDIDRMPEGGINLTPKDPRWVGAWWLGFLISSGLVVLASSPYFFFPREMPKEKHEFHFRRKVLASAASTASKGEDLSSQHEPLKKQAGLAQIAPDLTLVQFVKVFPRVLLRNLRHPIFLLVVLSQVCTSSMVAGMATFLPKFLERQFSITASFANMLLGCLTIPLVIVGIMMGGVLVKRLHLSPVQCSALCLLGSLLCLLFSVPLFFIGCSTHQIAGITQDLGAQPGPSLFPGCSEPCSCQSDDFNPVCDTSAYVEYTTPCHAGCTGRVVQEALGKSQVFYTNCSCVAGNGTVPAGSCESACSRLVLPFIVLFSLGAGLASITHTPSFMLILRGVKKEDKTLAVGMQFMLLRVLAWMPSPVIHGSAIDTTCVHWALTCGRRAVCRYYDHDLLRNRFIGLQFFFKSGSLVCFTLVLAILRQQSREASTRTTVKSSELQQL
uniprot
proteins
function
FUNCTION: Mediates the Na(+)-independent transport of steroid sulfate conjugates such as estrone 3-sulfate (E1S), dehydroepiandrosterone sulfate (DHEA-S) and pregnenolone sulfate (PregS) and other specific organic anions (PubMed:31123035). Responsible for the transport of E1S through the basal membrane of syncytiotrophoblast, highlighting a potential role in the placental absorption of fetal-derived sulfated steroids including DHEA-S (By similarity). Also facilitates the uptake of sulfated steroids at the basal/sinusoidal membrane of hepatocytes, therefore accounting for the major part of organic anions clearance of liver. Mediates the intestinal uptake of sulfated steroids. Mediates the uptake of the neurosteroids DHEA-S and PregS into the endothelial cells of the blood-brain barrier as the first step to enter the brain. Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons. May act as a heme transporter that promotes cellular iron availability. Also transports heme by-product coproporphyrin III (CPIII), and may be involved in their hepatic disposition (By similarity). Mediates the uptake of other substrates such as prostaglandins D2 (PGD2), E1 (PGE1) and E2 (PGE2), taurocholate, L-thyroxine, leukotriene C4 and thromboxane B2 (PubMed:31123035). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. The exact transport mechanism has not been yet deciphered but most likely involves an anion exchange, coupling the cellular uptake of organic substrate with the efflux of an anionic compound. Hydrogencarbonate/HCO3(-) acts as a probable counteranion that exchanges for organic anions. Cytoplasmic glutamate may also act as counteranion in the placenta. An inwardly directed proton gradient has also been proposed as the driving force of E1S uptake with a (H(+):E1S) stoichiometry of (1:1) (By similarity). {ECO:0000250|UniProtKB:O94956, ECO:0000269|PubMed:31123035}.
uniprot
proteins
mass_dalton
74531
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17208939
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31123035
uniprot
proteins
pubmed
32114507
uniprot
proteins
pubmed
34205780
uniprot
proteins
sequence_length
683
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O94956}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000250|UniProtKB:O94956}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:O94956}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..61; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 81..101; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 108..132; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 178..207; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 227..247; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 266..290; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 356..377; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 398..421; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 426..449; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 554..576; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 586..611; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 645..662; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins