EIF3H
entrez
8667
canonical
uniprot
O15372
canonical
ensembl
ENSG00000147677
resolver
ensp
ENSP00000429931
resolver
enst
ENST00000521861
resolver
genesymbol
EIF3H
resolver
genesymbol
EIF3S3
resolver
genesymbol_syn
EIF3H
resolver
genesymbol_syn
EIF3S3
resolver
hgnc
HGNC:3273
resolver
uniprot
Q6IB98
resolver
uniprot_entry
EIF3H_HUMAN
resolver
uniprot_entry
Q6IB98_HUMAN
resolver
amino_acid_sequence
MASRKEGTGSTATSSSSTAGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKANITFEYMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN
uniprot
proteins
function
FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.
uniprot
proteins
mass_dalton
39930
uniprot
proteins
protein_family
EIF-3 subunit H family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15703437
uniprot
proteins
pubmed
16286006
uniprot
proteins
pubmed
16322461
uniprot
proteins
pubmed
16766523
uniprot
proteins
pubmed
17322308
uniprot
proteins
pubmed
17581632
uniprot
proteins
pubmed
18599441
uniprot
proteins
pubmed
20068067
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25849773
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26100019
uniprot
proteins
pubmed
27462815
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
9341143
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
uniprot
proteins