P04757
uniprot
P04757
canonical
activity_regulation
ACTIVITY REGULATION: Activated by a myriad of ligands such as acetylcholine, cytisine, nicotine, choline and epibatidine (PubMed:10465681, PubMed:22250215). The heteropentamer CHRNA3:CHRNB2 activity is blocked by alpha-conotoxins ImI, ImII, PnIA, GID and MII (PubMed:16964981). The heteropentamer CHRNA3:CHRNB4 activity is blocked by the alpha-conotoxin ImI and AuIB (PubMed:15609996, PubMed:15929983, PubMed:22561751). {ECO:0000269|PubMed:10465681, ECO:0000269|PubMed:15609996, ECO:0000269|PubMed:15929983, ECO:0000269|PubMed:16964981, ECO:0000269|PubMed:22250215, ECO:0000269|PubMed:22561751}.
uniprot
proteins
amino_acid_sequence
MGVVLLPPPLSMLMLVLMLLPAASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSGEGDTPKTRTFYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSSESVNAVLSLSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFLQPLMARDDT
uniprot
proteins
function
FUNCTION: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:22250215, PubMed:22561751). CHRNA3 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4 (PubMed:22561751). CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (PubMed:22561751). CHRNA3:CHRNB4 also plays an important role in the habenulo-interpeduncular tract, modulating the mesolimbic dopamine system and affecting reward circuits and addiction (PubMed:22561751). Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity). Also expressed in the urothelium where it modulates reflex bladder activity by increasing intracellular calcium through extracellular influx and basal ATP release (PubMed:22250215). {ECO:0000250|UniProtKB:Q8R4G9, ECO:0000269|PubMed:22250215, ECO:0000269|PubMed:22561751}.
uniprot
proteins
mass_dalton
56998
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; by STUB1/CHIP and thereafter degraded by the 26S proteosome complex. {ECO:0000269|PubMed:19474315, ECO:0000269|PubMed:26265139}.
uniprot
proteins
protein_family
Acetylcholine receptor (TC 1.A.9.1) subfamily
uniprot
proteins
protein_family
Alpha-3/CHRNA3 sub-subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
10465681
uniprot
proteins
pubmed
15609996
uniprot
proteins
pubmed
15929983
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
16964981
uniprot
proteins
pubmed
19474315
uniprot
proteins
pubmed
22250215
uniprot
proteins
pubmed
22561751
uniprot
proteins
pubmed
2444984
uniprot
proteins
pubmed
26265139
uniprot
proteins
pubmed
3753746
uniprot
proteins
pubmed
8144606
uniprot
proteins
sequence_length
499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:19474315}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:19474315}. Golgi apparatus {ECO:0000269|PubMed:19474315}. Note=Interaction with UBXN2A/UBXD4 promotes translocation to the plasma membrane. {ECO:0000269|PubMed:19474315}.
uniprot
proteins
transmembrane_region
TRANSMEM 245..260; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P32297"; TRANSMEM 263..279; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P32297"; TRANSMEM 302..320; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P32297"; TRANSMEM 469..487; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P32297
uniprot
proteins