NRARP
entrez
441478
canonical
uniprot
Q7Z6K4
canonical
ensembl
ENSG00000198435
resolver
ensp
ENSP00000349041
resolver
enst
ENST00000356628
resolver
genesymbol
NRARP
resolver
hgnc
HGNC:33843
resolver
uniprot
B8A4K5
resolver
uniprot_entry
NRARP_HUMAN
resolver
uniprot_sec
B8A4K5
resolver
amino_acid_sequence
MSQAELSTCSAPQTQRIFQEAVRKGNTQELQSLLQNMTNCEFNVNSFGPEGQTALHQSVIDGNLELVKLLVKFGADIRLANRDGWSALHIAAFGGHQDIVLYLITKAKYAASGR
uniprot
proteins
function
FUNCTION: Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and down-regulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity). {ECO:0000250|UniProtKB:Q91ZA8, ECO:0000269|PubMed:19154719, ECO:0000269|PubMed:25985737, ECO:0000305|PubMed:25985737}.
uniprot
proteins
mass_dalton
12492
uniprot
proteins
protein_family
NRARP family
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19154719
uniprot
proteins
pubmed
25985737
uniprot
proteins
sequence_length
114
uniprot
proteins