Abcc1
entrez
24565
canonical
uniprot
Q8CG09
canonical
ensembl
ENSRNOG00000022305
resolver
ensembl
ENSRNOG00055005263
resolver
ensembl
ENSRNOG00060012339
resolver
ensembl
ENSRNOG00065002611
resolver
ensp
ENSRNOP00000044445
resolver
ensp
ENSRNOP00000073429
resolver
genesymbol
Abcc1
resolver
genesymbol_syn
Mrp1
resolver
uniprot
Q63346
resolver
uniprot
Q810E4
resolver
uniprot
Q810G9
resolver
uniprot
Q9JHS0
resolver
uniprot_entry
MRP1_RAT
resolver
uniprot_sec
Q63346
resolver
uniprot_sec
Q810E4
resolver
uniprot_sec
Q810G9
resolver
uniprot_sec
Q9JHS0
resolver
activity_regulation
ACTIVITY REGULATION: MK 571 inhibits sphingosine 1-phosphate and leukotriene C4 export. {ECO:0000250|UniProtKB:P33527, ECO:0000269|PubMed:17050692}.
uniprot
proteins
amino_acid_sequence
MALSSFCSSDGSDPLWDWNVTWHTSNPDFTKCFQNTVLTWVPCFYLWSCFPLYFLYLSRHDRGYIQMTHLNKAKTALGFFLWIICWADLFYSFWERSQGMLLAPVLLVSPTLLGITMLLATFLIQFERRKGVQSSGIMLTFWLVALLCALAILRSKIISALKKDAQVDMFRDSAFYLYFTLVFIQLVLSCFSDSSPLFSETVRDPNPCPESSASFLSRITFWWITGMMVQGYRQPLKSSDLWSLNKEDTSEEVVPVLVNNWKKECVKSRKQPVRIVYAPPKDPTKPKGSSQLDVNEEVEALIVKSSHKDRDPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPEILELIINFVNDREAPDWQGYLYTALLFVSACLQTLALHQYFHICFVTGMRIKTAVVGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVTLALYFLWLNLGPSVLAGVAVMILMVPFNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMNIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDEKNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERWSIKDGGGMNSITVKNATFTWARDEPPTLNGITFAIPDGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGRPLQEHCYKAVMEACALLPDLEILPSGDLTEIGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFVRTYANTEQDLASEDDSKNGVSGLGKESKPVENGILVTDAVGKPLQRHLSNSSSHSVVTNQQHSSTAELQKSGVKEETWKLMEADKAQTGQVKLSVYWNYMKAIGLCISFLSIFLFLCNHVSALASNYWLSLWTDDRPAVNGTQENRNFRLSVYGALGILQGVAVFGYSMAVSIGGIFASRRLHLDLLQNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEASWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTIMDYTRVIVLDKGEIRECGAPSELLQQRGVFYSMAKDAGLV
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
ec_number
7.6.2.3
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable the active transport of organic anions conjugated with glutathione, glucuronate or sulfate. Operates at the plasma membrane where it mediates the efflux of substrates from the cytoplasm into the extracellular space. The rate of transport is in some way coupled to the reduced glutathione (GSH) intracellular levels. Mediates the systemic release of glutathione-conjugated leukotriene C4 (LTC4) from myeloid cells such as mast cells, as part of the inflammatory response (By similarity). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells. Can export both GSH and its oxidized form GSSG in a protective mechanism that limits cellular damage especially during oxidative stress. Regulates GSH and GSSG release from astrocytes to maintain glutathione redox equilibrium in the brain (By similarity). Transports signaling molecules. Appears to selectively recognize cyclic 2'3'-GMP-AMP (cGAMP) produced by mammals but not 3'3'-cGAMP produced by bacteria. Mediates 2'3'-cGAMP export and limits intracellular cGAMP-mediated cGAS-STING signaling and type I interferon synthesis. Exports sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Confers resistance to anticancer drugs by mediating ATP- and GSH-dependent drug export. Similarly to MRP2, transports various steroids, bile acids and bilirubin conjugates (By similarity). {ECO:0000250|UniProtKB:O35379, ECO:0000250|UniProtKB:P33527, ECO:0000269|PubMed:15129170, ECO:0000269|PubMed:17050692}.
uniprot
proteins
mass_dalton
171493
uniprot
proteins
mutagenesis
MUTAGEN 983; /note="L->M: No effect on estradiol glucuronide transport."; /evidence="ECO:0000269|PubMed:12867490"; MUTAGEN 1090; /note="Q->E: 7.6-fold increase of the estradiol glucuronide transport; when associated with T-1243. Increases doxorubicin inhibition."; /evidence="ECO:0000269|PubMed:12867490"; MUTAGEN 1101; /note="S->N: 50% increase of estradiol glucuronide transport."; /evidence="ECO:0000269|PubMed:12867490"; MUTAGEN 1106; /note="V->C: No effect on estradiol glucuronide transport."; /evidence="ECO:0000269|PubMed:12867490"; MUTAGEN 1243; /note="A->T: 7.6-fold increase of the estradiol glucuronide transport; when associated with E-1090."; /evidence="ECO:0000269|PubMed:12867490
uniprot
proteins
post_translational_modification
PTM: Glycosylated.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCC family
uniprot
proteins
protein_family
Conjugate transporter (TC 3.A.1.208) subfamily
uniprot
proteins
pubmed
11208926
uniprot
proteins
pubmed
12423064
uniprot
proteins
pubmed
12867490
uniprot
proteins
pubmed
15129170
uniprot
proteins
pubmed
17050692
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8662992
uniprot
proteins
sequence_length
1532
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15129170}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P33527}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..50; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 76..90; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 107..120; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 137..150; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 173..188; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 330..343; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 368..382; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 444..457; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 470..485; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 546..561; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 587..600; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 973..989; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 1024..1039; /note="Helical; Name=13"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 1093..1109; /note="Helical; Name=14"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 1115..1127; /note="Helical; Name=15"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 1202..1215; /note="Helical; Name=16"; /evidence="ECO:0000250|UniProtKB:P33527"; TRANSMEM 1234..1247; /note="Helical; Name=17"; /evidence="ECO:0000250|UniProtKB:P33527
uniprot
proteins