Rorb
entrez
225998
canonical
uniprot
Q8R1B8
canonical
ensembl
ENSMUSG00000036192
resolver
ensp
ENSMUSP00000047597
resolver
ensp
ENSMUSP00000108447
resolver
ensp
ENSMUSP00000108451
resolver
enst
ENSMUST00000112828
resolver
genesymbol
Rorb
resolver
genesymbol_syn
Nr1f2
resolver
uniprot
A0A0R4J1H4
resolver
uniprot
Q0PQZ2
resolver
uniprot
Q0PQZ3
resolver
uniprot
Q1MVR9
resolver
uniprot_entry
A0A0R4J1H4_MOUSE
resolver
uniprot_entry
RORB_MOUSE
resolver
uniprot_sec
Q0PQZ2
resolver
uniprot_sec
Q0PQZ3
resolver
uniprot_sec
Q1MVR9
resolver
amino_acid_sequence
MCENQPKTKADGTAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNTETGGTYANGHVIDLPKSEGYYSIDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMSEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPDIVNTLFPPLYKELFNPDCAAVCK
uniprot
proteins
function
FUNCTION: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity. {ECO:0000250|UniProtKB:P45446}.; FUNCTION: Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4. {ECO:0000269|PubMed:23652001}.
uniprot
proteins
mass_dalton
53118
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16574740
uniprot
proteins
pubmed
17303680
uniprot
proteins
pubmed
19805139
uniprot
proteins
pubmed
21799210
uniprot
proteins
pubmed
22189870
uniprot
proteins
pubmed
23652001
uniprot
proteins
pubmed
9670004
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16574740}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q92753}.
uniprot
proteins