DCTN6
entrez
10671
canonical
uniprot
O00399
canonical
ensembl
ENSG00000104671
resolver
ensp
ENSP00000221114
resolver
enst
ENST00000221114
resolver
genesymbol
DCTN6
resolver
genesymbol_syn
WS3
resolver
hgnc
HGNC:16964
resolver
uniprot
B2RAC1
resolver
uniprot_entry
DCTN6_HUMAN
resolver
uniprot_sec
B2RAC1
resolver
amino_acid_sequence
MAEKTQKSVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQALIINAYPDNITPDTEDPEPKPMIIGTNNVFEVGCYSQAMKMGDNNVIESKAYVGRNVILTSGCIIGACCNLNTFEVIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKTMKGSSTPVKN
uniprot
proteins
function
FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000269|PubMed:23455152}.
uniprot
proteins
mass_dalton
20747
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase creates a binding site for PLK1 that facilitates its recruitment to kinetochores. {ECO:0000269|PubMed:23455152}.
uniprot
proteins
protein_family
Dynactin subunit 6 subfamily
uniprot
proteins
protein_family
Dynactin subunits 5/6 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23455152
uniprot
proteins
pubmed
9168138
uniprot
proteins
sequence_length
190
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:D0G6S1}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:23455152}.
uniprot
proteins