HEPH
entrez
9843
canonical
uniprot
Q9BQS7
canonical
ensembl
ENSG00000089472
resolver
ensp
ENSP00000337418
resolver
ensp
ENSP00000343939
resolver
ensp
ENSP00000398078
resolver
ensp
ENSP00000411687
resolver
ensp
ENSP00000413211
resolver
ensp
ENSP00000430620
resolver
ensp
ENSP00000557585
resolver
ensp
ENSP00000557586
resolver
ensp
ENSP00000557592
resolver
ensp
ENSP00000557596
resolver
ensp
ENSP00000557597
resolver
ensp
ENSP00000557600
resolver
ensp
ENSP00000557601
resolver
ensp
ENSP00000557602
resolver
ensp
ENSP00000557605
resolver
ensp
ENSP00000557613
resolver
ensp
ENSP00000601849
resolver
ensp
ENSP00000601851
resolver
ensp
ENSP00000601853
resolver
ensp
ENSP00000626663
resolver
ensp
ENSP00000626664
resolver
ensp
ENSP00000626670
resolver
ensp
ENSP00000626672
resolver
ensp
ENSP00000702008
resolver
enst
ENST00000419594
resolver
enst
ENST00000425114
resolver
enst
ENST00000441993
resolver
enst
ENST00000887526
resolver
enst
ENST00000887533
resolver
enst
ENST00000887543
resolver
enst
ENST00000931794
resolver
enst
ENST00000956604
resolver
enst
ENST00000956611
resolver
enst
ENST00000956613
resolver
genesymbol
HEPH
resolver
genesymbol_syn
KIAA0698
resolver
hgnc
HGNC:4866
resolver
uniprot
A0A0C4DG76
resolver
uniprot
B1AJX8
resolver
uniprot
D3DVT7
resolver
uniprot
E7ES21
resolver
uniprot
E9PHN8
resolver
uniprot
O75180
resolver
uniprot
Q5JZ08
resolver
uniprot
Q6UW45
resolver
uniprot
Q9C058
resolver
uniprot_entry
A0A0C4DG76_HUMAN
resolver
uniprot_entry
E7ES21_HUMAN
resolver
uniprot_entry
HEPH_HUMAN
resolver
uniprot_entry
Q5JZ08_HUMAN
resolver
uniprot_sec
B1AJX8
resolver
uniprot_sec
D3DVT7
resolver
uniprot_sec
E9PHN8
resolver
uniprot_sec
O75180
resolver
uniprot_sec
Q6UW45
resolver
uniprot_sec
Q9C058
resolver
amino_acid_sequence
MESGHLLWALLFMQSLWPQLTDGATRVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDEVAQPAWLGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITKETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ
uniprot
proteins
ec_number
1.16.3.1
uniprot
proteins
function
FUNCTION: Plasma membrane ferroxidase that mediates the extracellular conversion of ferrous/Fe(2+) iron into its ferric/Fe(3+) form. Couples ferroportin which specifically exports ferrous/Fe(2+) iron from cells to transferrin that only binds and shuttles extracellular ferric/Fe(3+) iron throughout the body (PubMed:22961397, PubMed:37277838). By helping iron transfer from cells to blood mainly contributes to dietary iron absorption by the intestinal epithelium and more generally regulates iron levels in the body (By similarity). {ECO:0000250|UniProtKB:Q9Z0Z4, ECO:0000269|PubMed:22961397, ECO:0000269|PubMed:37277838}.
uniprot
proteins
mass_dalton
130449
uniprot
proteins
mutagenesis
MUTAGEN 264; /note="E->A: Decreased affinity for Fe(2+) and decreased ferroxidase activity; when associated with A-269, A-616 and A-621. Loss of affinity for Fe(2+) and loss of ferroxidase activity; when associated with A-269, A-960 and A-965."; /evidence="ECO:0000269|PubMed:22961397"; MUTAGEN 269; /note="H->A: Decreased affinity for Fe(2+) and decreased ferroxidase activity; when associated with A-264, A-616 and A-621. Loss of affinity for Fe(2+) and loss of ferroxidase activity; when associated with A-264, A-960 and A-965."; /evidence="ECO:0000269|PubMed:22961397"; MUTAGEN 616; /note="D->A: Decreased affinity for Fe(2+) and decreased ferroxidase activity; when associated with A-264, A-269 and A-621."; /evidence="ECO:0000269|PubMed:22961397"; MUTAGEN 621; /note="H->A: Decreased affinity for Fe(2+) and decreased ferroxidase activity; when associated with A-264, A-269 and A-616."; /evidence="ECO:0000269|PubMed:22961397"; MUTAGEN 960; /note="E->A: Loss of affinity for Fe(2+) and loss of ferroxidase activity; when associated with A-264, A-269 and A-965."; /evidence="ECO:0000269|PubMed:22961397"; MUTAGEN 965; /note="H->A: Loss of affinity for Fe(2+) and loss of ferroxidase activity; when associated with A-264, A-269 and A-960."; /evidence="ECO:0000269|PubMed:22961397
uniprot
proteins
protein_family
Multicopper oxidase family
uniprot
proteins
pubmed
11932491
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17486601
uniprot
proteins
pubmed
20019163
uniprot
proteins
pubmed
22961397
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
37277838
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
1158
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:17486601, ECO:0000269|PubMed:20019163}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 1111..1131; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins