TAS1R3
entrez
83756
canonical
uniprot
Q7RTX0
canonical
ensembl
ENSG00000169962
resolver
ensp
ENSP00000344411
resolver
enst
ENST00000339381
resolver
genesymbol
TAS1R3
resolver
genesymbol_syn
T1R3
resolver
genesymbol_syn
TR3
resolver
hgnc
HGNC:15661
resolver
uniprot
Q5TA49
resolver
uniprot
Q8NGW9
resolver
uniprot_entry
TS1R3_HUMAN
resolver
uniprot_sec
Q5TA49
resolver
uniprot_sec
Q8NGW9
resolver
amino_acid_sequence
MLGPAVLGLSLWALLHPGTGAPLCLSQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTRFSSNGLLWALAMKMAVEEINNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKAGSRDIAAYCNYTQYQPRVLAVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRVQLTAAAELLQEFGWNWVAALGSDDEYGRQGLSIFSALAAARGICIAHEGLVPLPRADDSRLGKVQDVLHQVNQSSVQVVLLFASVHAAHALFNYSISSRLSPKVWVASEAWLTSDLVMGLPGMAQMGTVLGFLQRGAQLHEFPQYVKTHLALATDPAFCSALGEREQGLEEDVVGQRCPQCDCITLQNVSAGLNHHQTFSVYAAVYSVAQALHNTLQCNASGCPAQDPVKPWQLLENMYNLTFHVGGLPLRFDSSGNVDMEYDLKLWVWQGSVPRLHDVGRFNGSLRTERLKIRWHTSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDCVDCEAGSYRQNPDDIACTFCGQDEWSPERSTRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDSPLVQASGGPLACFGLVCLGLVCLSVLLFPGQPSPARCLAQQPLSHLPLTGCLSTLFLQAAEIFVESELPLSWADRLSGCLRGPWAWLVVLLAMLVEVALCTWYLVAFPPEVVTDWHMLPTEALVHCRTRSWVSFGLAHATNATLAFLCFLGTFLVRSQPGCYNRARGLTFAMLAYFITWVSFVPLLANVQVVLRPAVQMGALLLCVLGILAAFHLPRCYLLMRQPGLNTPEFFLGGGPGDAQGQNDGNTGNQGKHE
uniprot
proteins
function
FUNCTION: Key component of the sweet and umami taste receptors (PubMed:11917125, PubMed:40339580, PubMed:40754567, PubMed:40555359). TAS1R1 and TAS1R3 form the umami receptor and respond to the umami taste stimulus (the taste of monosodium glutamate) (PubMed:11917125). TAS1R2 and TAS1R3 form the sweet taste receptor and recognize diverse natural and synthetic sweeteners (PubMed:11917125, PubMed:40339580, PubMed:40754567, PubMed:40555359). The sweet taste receptor has lower affinity for natural sugars than for synthetic sweeteners (PubMed:40339580, PubMed:40555359). Essential for the recognition and response to the disaccharide trehalose (PubMed:12892531). Functions as a G protein-coupled receptor and primarily signals through the gustducin heterotrimer (PubMed:40339580). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity). {ECO:0000250|UniProtKB:Q49KI5, ECO:0000269|PubMed:11917125, ECO:0000269|PubMed:12892531, ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567}.
uniprot
proteins
mass_dalton
93386
uniprot
proteins
mutagenesis
MUTAGEN 514; /note="F->A: Impairs receptor response to sucralose."; /evidence="ECO:0000269|PubMed:40555359"; MUTAGEN 515; /note="H->A: Impairs receptor response to sucralose."; /evidence="ECO:0000269|PubMed:40555359"; MUTAGEN 537; /note="A->G: Retains partial activity toward brazzein; however response to other sweeteners tested is suppressed."; /evidence="ECO:0000269|PubMed:15299024"; MUTAGEN 537; /note="A->P: Receptor unresponsive to all sweeteners tested."; /evidence="ECO:0000269|PubMed:15299024"; MUTAGEN 537; /note="A->T,S,E,V: Abolished the response to brazzein."; /evidence="ECO:0000269|PubMed:15299024"; MUTAGEN 540; /note="F->A,H: Reduces the response to brazzein and monellin."; /evidence="ECO:0000269|PubMed:15299024"; MUTAGEN 540; /note="F->L: Reduces the response to monellin."; /evidence="ECO:0000269|PubMed:15299024"; MUTAGEN 540; /note="F->Y,P: Reduces the response to brazzein; P-540 also enhances responses to the small molecule sweeteners."; /evidence="ECO:0000269|PubMed:15299024
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
protein_family
TAS1R subfamily
uniprot
proteins
pubmed
11917125
uniprot
proteins
pubmed
12892531
uniprot
proteins
pubmed
15299024
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
40339580
uniprot
proteins
pubmed
40555359
uniprot
proteins
pubmed
40754567
uniprot
proteins
sequence_length
852
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567}; Multi-pass membrane protein {ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567}.
uniprot
proteins
transmembrane_region
TRANSMEM 571..591; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567, ECO:0000312|PDB:9UT8, ECO:0007744|PDB:9NOR"; TRANSMEM 604..624; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567, ECO:0000312|PDB:9UT8, ECO:0007744|PDB:9NOR"; TRANSMEM 640..660; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567, ECO:0000312|PDB:9UT8, ECO:0007744|PDB:9NOR"; TRANSMEM 683..703; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567, ECO:0000312|PDB:9UT8, ECO:0007744|PDB:9NOR"; TRANSMEM 730..750; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567, ECO:0000312|PDB:9UT8, ECO:0007744|PDB:9NOR"; TRANSMEM 763..783; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567, ECO:0000312|PDB:9UT8, ECO:0007744|PDB:9NOR"; TRANSMEM 790..813; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567, ECO:0000312|PDB:9UT8, ECO:0007744|PDB:9NOR
uniprot
proteins