AKR7A3
entrez
22977
canonical
uniprot
O95154
canonical
ensembl
ENSG00000162482
resolver
ensp
ENSP00000355377
resolver
ensp
ENSP00000643631
resolver
enst
ENST00000361640
resolver
genesymbol
AKR7A3
resolver
genesymbol_syn
AFAR2
resolver
hgnc
HGNC:390
resolver
uniprot
A0A384MDN8
resolver
uniprot
Q86SR4
resolver
uniprot
Q8IVN6
resolver
uniprot
Q8N5V6
resolver
uniprot
Q8TAX1
resolver
uniprot
Q9NUC3
resolver
uniprot_entry
A0A384MDN8_HUMAN
resolver
uniprot_entry
ARK73_HUMAN
resolver
uniprot_sec
Q86SR4
resolver
uniprot_sec
Q8IVN6
resolver
uniprot_sec
Q8N5V6
resolver
uniprot_sec
Q8TAX1
resolver
uniprot_sec
Q9NUC3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by citrate. {ECO:0000250|UniProtKB:P38918}.
uniprot
proteins
amino_acid_sequence
MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVTHECPNYFR
uniprot
proteins
ec_number
1.1.1.2
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of various carbonyl-containing compounds, including aldehydes, ketones, and toxic products from cellular metabolism or environmental exposure. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates, thus preventing the formation of protein adducts that contribute to AFB1-induced toxicity. {ECO:0000269|PubMed:10383892, ECO:0000269|PubMed:11409944, ECO:0000269|PubMed:18416522}.
uniprot
proteins
mass_dalton
37206
uniprot
proteins
protein_family
Aldo/keto reductase 2 subfamily
uniprot
proteins
protein_family
Aldo/keto reductase family
uniprot
proteins
pubmed
10383892
uniprot
proteins
pubmed
11409944
uniprot
proteins
pubmed
12879023
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18416522
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P38918}.
uniprot
proteins