Pnmt
entrez
24661
canonical
uniprot
P10937
canonical
ensembl
ENSRNOG00000046057
resolver
ensp
ENSRNOP00000067392
resolver
genesymbol
Pnmt
resolver
uniprot_entry
PNMT_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 3-methyl-l,2,3,4-tetrahydro[1]benzothieno[3,2-c]pyridine hydrochloride. {ECO:0000269|PubMed:683413}.
uniprot
proteins
amino_acid_sequence
MDRGSDPKHTAGMDSDSDPGQAEVALAYQRFEPRAYLRNNYAPPRGDLSNPDGVGPWKLRCMAQVFATGEVSGQVLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELGLWLREEPGAFDWSVYSQHVCLIEDKGESWQEKERQLRARVKRVLPIDVHKPQPLGASGLAPLPADALVSAFCLEAVSPDLPSFRQALYHITTLLRPGGNLLFIGALEESWYLAGEARLSVVPVSEEEVREALVCSGYEVRDLRTYIMPAHLRTGVDDVKGIFFAWAQKIEVQV
uniprot
proteins
ec_number
2.1.1.28
uniprot
proteins
function
FUNCTION: Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (By similarity). Other substrates include phenylethanolamine, octopamine and normetanephrine (PubMed:13863458, PubMed:683413). {ECO:0000250|UniProtKB:P11086, ECO:0000269|PubMed:13863458, ECO:0000269|PubMed:683413}.
uniprot
proteins
mass_dalton
31670
uniprot
proteins
pathway_participation
PATHWAY: Catecholamine biosynthesis; (R)-adrenaline biosynthesis; (R)-adrenaline from (R)-noradrenaline: step 1/1. {ECO:0000250|UniProtKB:P11086}.
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
NNMT/PNMT/TEMT family
uniprot
proteins
pubmed
13863458
uniprot
proteins
pubmed
2575695
uniprot
proteins
pubmed
2928117
uniprot
proteins
pubmed
683413
uniprot
proteins
pubmed
7558218
uniprot
proteins
pubmed
7931317
uniprot
proteins
sequence_length
285
uniprot
proteins