EIF3D
entrez
8664
canonical
uniprot
O15371
canonical
ensembl
ENSG00000100353
resolver
ensp
ENSP00000216190
resolver
ensp
ENSP00000390438
resolver
genesymbol
EIF3D
resolver
genesymbol_syn
EIF3S7
resolver
hgnc
HGNC:3278
resolver
uniprot
A8MWD3
resolver
uniprot
B2R7D4
resolver
uniprot
B4DTF8
resolver
uniprot
B4DVY1
resolver
uniprot
Q3MJD9
resolver
uniprot
Q5M9Q6
resolver
uniprot_entry
EIF3D_HUMAN
resolver
uniprot_sec
A8MWD3
resolver
uniprot_sec
B2R7D4
resolver
uniprot_sec
B4DTF8
resolver
uniprot_sec
B4DVY1
resolver
uniprot_sec
Q3MJD9
resolver
uniprot_sec
Q5M9Q6
resolver
amino_acid_sequence
MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDESSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMLQFNLQILPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEEEEET
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in EIF3D are associated with some cancers, such as prostate, breast and colon cancers. Disease susceptibility may be associated with variants affecting the gene represented in this entry. Down-regulation inhibits proliferation of cancers (PubMed:25322666, PubMed:25370813, PubMed:25682860, PubMed:26008152, PubMed:26036682, PubMed:26617750, PubMed:27035563). {ECO:0000269|PubMed:25322666, ECO:0000269|PubMed:25370813, ECO:0000269|PubMed:25682860, ECO:0000269|PubMed:26008152, ECO:0000269|PubMed:26036682, ECO:0000269|PubMed:26617750, ECO:0000269|PubMed:27035563}.
uniprot
proteins
function
FUNCTION: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815). {ECO:0000269|PubMed:18599441, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
uniprot
proteins
mass_dalton
63973
uniprot
proteins
mutagenesis
MUTAGEN 249; /note="D->Q: Reduced binding to JUN mRNA; when associated with 262-I-A-263."; /evidence="ECO:0000269|PubMed:27462815"; MUTAGEN 262..263; /note="VY->IA: Reduced binding to JUN mRNA; when associated with Q-249."; /evidence="ECO:0000269|PubMed:27462815"; MUTAGEN 317..321; /note="TYINH->EYENA: Reduced binding to JUN mRNA."; /evidence="ECO:0000269|PubMed:27462815
uniprot
proteins
protein_family
EIF-3 subunit D family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12773399
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15703437
uniprot
proteins
pubmed
16322461
uniprot
proteins
pubmed
16766523
uniprot
proteins
pubmed
17322308
uniprot
proteins
pubmed
17581632
uniprot
proteins
pubmed
18056426
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18599441
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25322666
uniprot
proteins
pubmed
25370813
uniprot
proteins
pubmed
25682860
uniprot
proteins
pubmed
25787250
uniprot
proteins
pubmed
25849773
uniprot
proteins
pubmed
26008152
uniprot
proteins
pubmed
26036682
uniprot
proteins
pubmed
26617750
uniprot
proteins
pubmed
27035563
uniprot
proteins
pubmed
27462815
uniprot
proteins
pubmed
9341143
uniprot
proteins
sequence_length
548
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03003}.
uniprot
proteins