SULT1C2
entrez
6819
canonical
uniprot
O00338
canonical
ensembl
ENSG00000198203
resolver
ensp
ENSP00000251481
resolver
ensp
ENSP00000319622
resolver
genesymbol
SULT1C2
resolver
genesymbol_syn
SULT1C1
resolver
hgnc
HGNC:11456
resolver
uniprot
B2R813
resolver
uniprot
Q53SG4
resolver
uniprot_entry
ST1C2_HUMAN
resolver
uniprot_sec
B2R813
resolver
uniprot_sec
Q53SG4
resolver
amino_acid_sequence
MALTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSGVEKAKAMPSPRILKTHLSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTVSKSILDQSISSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSINFCMEL
uniprot
proteins
ec_number
2.8.2.1
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the sulfate conjugation of phenolic compounds (PubMed:10481272, PubMed:10783263, PubMed:9852044). Does not transfer sulfate to steroids, dopamine, acetaminophen, or alpha-naphthol (PubMed:10481272, PubMed:9852044). Except in mitochondria, where it can add sulfate to cholesterol producing cholesterol sulfate, which alters mitochondrial membrane organization, and impacts protein complex mobility increasing state-III respiration, thereby modulating mitochondrial respiration (By similarity). Catalyzes the sulfation of the carcinogenic N-hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:9852044). {ECO:0000250|UniProtKB:Q9WUW8, ECO:0000269|PubMed:10481272, ECO:0000269|PubMed:10783263, ECO:0000269|PubMed:9852044}.
uniprot
proteins
mass_dalton
34880
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
10481272
uniprot
proteins
pubmed
10783263
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16804942
uniprot
proteins
pubmed
9169148
uniprot
proteins
pubmed
9635888
uniprot
proteins
pubmed
9852044
uniprot
proteins
sequence_length
296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O46503}. Lysosome {ECO:0000250|UniProtKB:Q9WUW8}. Mitochondrion {ECO:0000250|UniProtKB:Q9WUW8}.
uniprot
proteins