Ing3
entrez
71777
canonical
uniprot
Q8VEK6
canonical
ensembl
ENSMUSG00000029670
resolver
ensp
ENSMUSP00000031680
resolver
ensp
ENSMUSP00000111047
resolver
ensp
ENSMUSP00000344406
resolver
enst
ENSMUST00000031680
resolver
enst
ENSMUST00000115389
resolver
genesymbol
Ing3
resolver
uniprot
D3YUP8
resolver
uniprot
Q99JS6
resolver
uniprot
Q9ERB2
resolver
uniprot_entry
D3YUP8_MOUSE
resolver
uniprot_entry
ING3_MOUSE
resolver
uniprot_sec
Q99JS6
resolver
uniprot_sec
Q9ERB2
resolver
amino_acid_sequence
MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREEQMASIKKDYYKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILERRSLELDAPSQPVNNHHAHSHTPVEKRKYNPTSHHAAADHIPEKKFKSEALLSTLTSDASKENTLGCRNNNSTASCNNAYNVNSSQPLASYNIGSLSSGAGAGAITMAAAQAVQATAQMKEGRRTSSLKASYEAFKNNDFQLGKEFSIPRETAGYSSSSALMTTLTQNASSSATDSRSGRKSKNNTKSSSQQSSSSSSSSSSSSLSLCSSSSTVVQEVSQQATVVPESDSNSQVDWTYDPNEPRYCICNQVSYGEMVGCDNQDCPIEWFHYGCVGLTEAPKGKWFCPQCTAAMKRRGSRHK
uniprot
proteins
function
FUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
46847
uniprot
proteins
protein_family
ING family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins