DCTN4
entrez
51164
canonical
uniprot
Q9UJW0
canonical
ensembl
ENSG00000132912
resolver
ensp
ENSP00000411251
resolver
ensp
ENSP00000414906
resolver
ensp
ENSP00000416968
resolver
genesymbol
DCTN4
resolver
hgnc
HGNC:15518
resolver
uniprot
A0A0S2Z5D4
resolver
uniprot
B3KWW0
resolver
uniprot
D3DQH0
resolver
uniprot
E5RGT5
resolver
uniprot
Q8TAN8
resolver
uniprot_entry
A0A0S2Z5D4_HUMAN
resolver
uniprot_entry
DCTN4_HUMAN
resolver
uniprot_sec
B3KWW0
resolver
uniprot_sec
D3DQH0
resolver
uniprot_sec
E5RGT5
resolver
uniprot_sec
Q8TAN8
resolver
amino_acid_sequence
MASLLQSDRVLYLVQGEKKVRAPLSQLYFCRYCSELRSLECVSHEVDSHYCPSCLENMPSAEAKLKKNRCANCFDCPGCMHTLSTRATSISTQLPDDPAKTTMKKAYYLACGFCRWTSRDVGMADKSVASGGWQEPENPHTQRMNKLIEYYQQLAQKEKVERDRKKLARRRNYMPLAFSDKYGLGTRLQRPRAGASISTLAGLSLKEGEDQKEIKIEPAQAVDEVEPLPEDYYTRPVNLTEVTTLQQRLLQPDFQPVCASQLYPRHKHLLIKRSLRCRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLFECEEGDPDDINSTAKVVVPPKELVLAGKDAAAEYDELAEPQDFQDDPDIIAFRKANKVGIFIKVTPQREEGEVTVCFKMKHDFKNLAAPIRPIEESDQGTEVIWLTQHVELSLGPLLP
uniprot
proteins
function
FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:A0A4X1TB62}.
uniprot
proteins
mass_dalton
52337
uniprot
proteins
mutagenesis
MUTAGEN 30; /note="C->S: Loss of ATP7B-binding; when associated with S-33; S-51; S-54; S-70, S-73; S-76; S-79; S-111; S-114; S-277 and S-280."; /evidence="ECO:0000269|PubMed:16554302"; MUTAGEN 33; /note="C->S: Loss of ATP7B-binding; when associated with S-30; S-51; S-54; S-70, S-73; S-76; S-79; S-111; S-114; S-277 and S-280."; /evidence="ECO:0000269|PubMed:16554302"; MUTAGEN 51; /note="C->S: Loss of ATP7B-binding; when associated with S-30; S-33; S-54; S-70, S-73; S-76; S-79; S-111; S-114; S-277 and S-280."; /evidence="ECO:0000269|PubMed:16554302"; MUTAGEN 54; /note="C->S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-70, S-73; S-76; S-79; S-111; S-114; S-277 and S-280."; /evidence="ECO:0000269|PubMed:16554302"; MUTAGEN 70; /note="C->S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-73; S-76; S-79; S-111; S-114; S-277 and S-280."; /evidence="ECO:0000269|PubMed:16554302"; MUTAGEN 73; /note="C->S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-76; S-79; S-111; S-114; S-277 and S-280."; /evidence="ECO:0000269|PubMed:16554302"; MUTAGEN 76; /note="C->S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-79; S-111; S-114; S-277 and S-280."; /evidence="ECO:0000269|PubMed:16554302"; MUTAGEN 79; /note="C->S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-76; S-111; S-114; S-277 and S-280."; /evidence="ECO:0000269|PubMed:16554302"; MUTAGEN 111; /note="C->S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-76; S-79; S-114; S-277 and S-280."; /evidence="ECO:0000269|PubMed:16554302"; MUTAGEN 114; /note="C->S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-76; S-79; S-111; S-277 and S-280."; /evidence="ECO:0000269|PubMed:16554302"; MUTAGEN 277; /note="C->S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-76; S-79; S-111; S-114 and S-280."; /evidence="ECO:0000269|PubMed:16554302"; MUTAGEN 280; /note="C->S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-76; S-79; S-111; S-114 and S-277."; /evidence="ECO:0000269|PubMed:16554302
uniprot
proteins
protein_family
Dynactin subunit 4 family
uniprot
proteins
pubmed
10671518
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554302
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
460
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10671518}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10671518}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q9QUR2}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9QUR2}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q8CBY8}. Note=Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin (PubMed:10671518). Overexpression in cultured mammalian cells revealed colocalization with cortical actin, stress fibers, and focal adhesion sites, sites of potential interaction between microtubules and the cell cortex (By similarity). In skeletal muscles, costamere localization requires the presence of ANK2 (By similarity). {ECO:0000250|UniProtKB:Q8CBY8, ECO:0000250|UniProtKB:Q9QUR2, ECO:0000269|PubMed:10671518}.
uniprot
proteins