B4galt1
entrez
14595
canonical
uniprot
P15535
canonical
ensembl
ENSMUSG00000028413
resolver
ensp
ENSMUSP00000030121
resolver
genesymbol
B4galt1
resolver
genesymbol_syn
Ggtb
resolver
genesymbol_syn
Ggtb2
resolver
uniprot
Q3TJS1
resolver
uniprot
Q3U478
resolver
uniprot_entry
B4GT1_MOUSE
resolver
uniprot_entry
Q3TJS1_MOUSE
resolver
uniprot_entry
Q3U478_MOUSE
resolver
amino_acid_sequence
MRFREQFLGGSAAMPGATLQRACRLLVAVCALHLGVTLVYYLSGRDLSRLPQLVGVSSTLQGGTNGAAASKQPPGEQRPRGARPPPPLGVSPKPRPGLDSSPGAASGPGLKSNLSSLPVPTTTGLLSLPACPEESPLLVGPMLIDFNIAVDLELLAKKNPEIKTGGRYSPKDCVSPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGDTMFNRAKLLNIGFQEALKDYDYNCFVFSDVDLIPMDDRNAYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLAINGFPNNYWGWGGEDDDIFNRLVHKGMSISRPNAVVGRCRMIRHSRDKKNEPNPQRFDRIAHTKETMRFDGLNSLTYKVLDVQRYPLYTQITVDIGTPR
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.1.22
uniprot
proteins
ec_number
2.4.1.275
uniprot
proteins
ec_number
2.4.1.38
uniprot
proteins
ec_number
2.4.1.90
uniprot
proteins
function
FUNCTION: Galactosyltransferase acting in the Golgi stacks. Catalyzes the transfer of galactose (Gal) from UDP-alpha-D-galactose in beta(1->4) linkage to the non-reducing terminal N-acetylglucosamine (GlcNAc) moieties of glycolipids and complex-type N-linked glycans (By similarity). Adds one Gal residue to both GlcNAc beta(1->2)-linked to the alpha(1->3) and alpha(1->6) mannose antennae of complex-type N-glycans, enabling the formation of mono- and di-galactosylated glycoforms (By similarity). Galactosylates complex-type N-glycans attached on the fragment crystallizable (Fc) of immunoglobulin-gamma isotypes (IgGs), a prerequisite for antibody glycan sialylation and related anti-inflammatory effector functions (By similarity). Can also transfer a Gal residue to free GlcNAc to form N-acetyllactosamine (By similarity). With LALBA/alpha-lactalbumin forms the lactose synthase complex responsible for production of large amounts of lactose in the lactating mammary gland. Interaction with LALBA alters the sugar substrate specificity of the catalytic domain, enabling high affinity binding of glucose and its transformation to lactose (By similarity). {ECO:0000250|UniProtKB:P08037, ECO:0000250|UniProtKB:P15291}.; FUNCTION: [Isoform Long]: The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, like those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix. Acts as a sperm receptor for ZP3 O-linked glycans on the zona pellucida leading to activation of G protein signaling and acrosome reaction. {ECO:0000269|PubMed:9374408}.; FUNCTION: [Processed beta-1,4-galactosyltransferase 1]: The secreted form is proficient in galactosyltransferase activity and could be involved in glycan remodeling in biological fluids. {ECO:0000250|UniProtKB:P08037}.
uniprot
proteins
mass_dalton
44411
uniprot
proteins
mutagenesis
MUTAGEN 353; /note="N->S: Homozygous and heterozygous mice show lower body weight compared with wild-type animals and reduced LDL-cholesterol and plasma fibrinogen levels."; /evidence="ECO:0000269|PubMed:34855475
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:P15291}.; PATHWAY: Glycolipid biosynthesis. {ECO:0000250|UniProtKB:P08037}.
uniprot
proteins
post_translational_modification
PTM: The soluble form derives from the membrane forms by proteolytic processing.
uniprot
proteins
protein_family
Glycosyltransferase 7 family
uniprot
proteins
pubmed
11145975
uniprot
proteins
pubmed
1384819
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1689054
uniprot
proteins
pubmed
18511602
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2504153
uniprot
proteins
pubmed
3134348
uniprot
proteins
pubmed
3141392
uniprot
proteins
pubmed
3149531
uniprot
proteins
pubmed
34855475
uniprot
proteins
pubmed
8314795
uniprot
proteins
pubmed
9374408
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P15291}; Single-pass type II membrane protein {ECO:0000255}. Note=Colocalizes with MGAT3 and ST6GAL1 in the Golgi stacks of cisternae, including the cis-part of the Golgi stacks. {ECO:0000250|UniProtKB:P15291}.; SUBCELLULAR LOCATION: [Isoform Long]: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:18511602}; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cell surface. Cell projection, filopodium {ECO:0000269|PubMed:18511602}. Note=Found in trans cisternae of Golgi. B4GALT1 cell surface expression is regulated by UBE2Q1 (PubMed:18511602). {ECO:0000269|PubMed:18511602}.; SUBCELLULAR LOCATION: [Isoform Short]: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:3149531}; Single-pass type II membrane protein {ECO:0000269|PubMed:3149531}. Note=Found in trans cisternae of Golgi. {ECO:0000269|PubMed:3149531}.; SUBCELLULAR LOCATION: [Processed beta-1,4-galactosyltransferase 1]: Secreted {ECO:0000250|UniProtKB:P15291}. Note=Soluble form found in body fluids. {ECO:0000250|UniProtKB:P15291}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..44; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins