Cibar1
entrez
68099
canonical
uniprot
Q8BP22
canonical
ensembl
ENSMUSG00000028218
resolver
ensp
ENSMUSP00000084284
resolver
ensp
ENSMUSP00000103920
resolver
ensp
ENSMUSP00000135961
resolver
enst
ENSMUST00000087052
resolver
enst
ENSMUST00000108285
resolver
genesymbol
Cibar1
resolver
genesymbol_syn
Fam92a
resolver
genesymbol_syn
Fam92a1
resolver
uniprot
A0A8Q0KEJ4
resolver
uniprot
A2AVA5
resolver
uniprot
A2AVA6
resolver
uniprot
A2AVA7
resolver
uniprot
Q7TNQ9
resolver
uniprot
Q8C2F8
resolver
uniprot
Q8VDU6
resolver
uniprot
Q9D2J3
resolver
uniprot
Z4YJZ2
resolver
uniprot_entry
A0A8Q0KEJ4_MOUSE
resolver
uniprot_entry
CBAR1_MOUSE
resolver
uniprot_entry
Z4YJZ2_MOUSE
resolver
uniprot_sec
A2AVA5
resolver
uniprot_sec
A2AVA6
resolver
uniprot_sec
A2AVA7
resolver
uniprot_sec
Q7TNQ9
resolver
uniprot_sec
Q8C2F8
resolver
uniprot_sec
Q8VDU6
resolver
uniprot_sec
Q9D2J3
resolver
amino_acid_sequence
MLRRNLDERDAQTKQLQDAVTNVEKHFGELCQIFAAYVRKTARLRDKADLLVNEINLYASTETPNLKQGLKDFADEFAKLQDYRQAEVERLEAKVVEPLKAYGTIVKMKRDDLKATLTARNREAKQLSQLERTRQRNPSDRHVISQAETELQRATIDATRTSRHLEETIDNFEKQKIKDIKNILSEFITIEMLFHGKALEVFTAAYQNIQNIDEDEDLEVFRNSLYLSDYPSRLDIVRANSKSPLQRSLSTKCTSGTGQISTCRTRKDQQVEDEDDEELDVTEDEN
uniprot
proteins
function
FUNCTION: Plays a critical role in regulating mitochondrial ultrastructure and function by maintaining the integrity of mitochondrial morphology, particularly the organization of cristae (By similarity). Preferentially binds to negatively charged phospholipids like cardiolipin and phosphatidylinositol 4,5-bisphosphate enhancing its interaction with mitochondrial membranes (By similarity). Induces membrane curvature and tubulation, which are critical for maintaining mitochondrial ultrastructure and the organization of cristae (By similarity). Plays a crucial role in ciliogenesis (PubMed:29459677). May play a role in limb development through its role in ciliogenesis (PubMed:30395363). Plays a key role in the correct positioning of the annulus, a septin-based ring structure in the sperm flagellum, serving both as a physical barrier and a membrane diffusion barrier that separates the midpiece (MP) from the principal piece (PP) (PubMed:38197861). This positioning is essential for proper sperm motility and function (PubMed:38197861). Interacts with CBY3 to form a complex which localizes to the curved membrane region of the flagellar pocket (PubMed:38197861). By doing so, may provide stability and rigidity to the periannular membrane to prevent membrane deformation (PubMed:38197861). This function is crucial for halting annulus migration at the proximal end of the fibrous sheath-containing PP (PubMed:38197861). {ECO:0000250|UniProtKB:A1XBS5, ECO:0000269|PubMed:29459677, ECO:0000269|PubMed:30395363, ECO:0000269|PubMed:38197861}.
uniprot
proteins
mass_dalton
33119
uniprot
proteins
protein_family
CIBAR family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27528616
uniprot
proteins
pubmed
29459677
uniprot
proteins
pubmed
30395363
uniprot
proteins
pubmed
30404948
uniprot
proteins
pubmed
38197861
uniprot
proteins
sequence_length
286
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A1XBS5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:A1XBS5}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27528616}. Cell projection, cilium {ECO:0000269|PubMed:29459677}. Nucleus {ECO:0000250|UniProtKB:A1XBS5}. Mitochondrion inner membrane {ECO:0000305|PubMed:30404948}; Peripheral membrane protein {ECO:0000250|UniProtKB:A1XBS5}; Matrix side {ECO:0000250|UniProtKB:A1XBS5}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:38197861}. Note=Weak punctate vesicular distribution throughout the cytoplasm. Localizes at the distal end of mother centrioles. Extensive colocalization with CBY1 at mother centrioles (PubMed:27528616). Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:29459677). Localizes to the annulus at the junction between the midpiece (MP) and principal piece (PP) of the sperm flagellum (PubMed:38197861). {ECO:0000250|UniProtKB:A1XBS5, ECO:0000269|PubMed:27528616, ECO:0000269|PubMed:29459677, ECO:0000269|PubMed:38197861}.
uniprot
proteins