Tshz3
entrez
243931
canonical
uniprot
Q8CGV9
canonical
ensembl
ENSMUSG00000021217
resolver
ensp
ENSMUSP00000021641
resolver
enst
ENSMUST00000021641
resolver
genesymbol
Tshz3
resolver
genesymbol_syn
Kiaa1474
resolver
genesymbol_syn
Tsh3
resolver
genesymbol_syn
Zfp537
resolver
genesymbol_syn
Znf537
resolver
uniprot
A0A0R4J017
resolver
uniprot
Q5DTX4
resolver
uniprot_entry
A0A0R4J017_MOUSE
resolver
uniprot_entry
TSH3_MOUSE
resolver
uniprot_sec
Q5DTX4
resolver
amino_acid_sequence
MPRRKQQAPRRAAAYVSDELKAAALVEDDVEPEEQAADGEPSAKYMCPEKELSKACPSYQNSPAAEFSSHEMDSESHISETSDRMADFESSSIKNEEETKEVQVPLEDTTVSDSLEQMKAVYNNFLSNSYWSNLNLNLHQPSSENNGGSSSSSSSSSSSCGSGSFDWHQSAMAKTLQQVSQNRMLPEPSLFSTVQLYRQSSKLYGSIFTGASKFRCKDCSAAYDTLVELTVHMNETGHYRDDNHETDNNNPKRWSKPRKRSLLEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVTPVAAKIIPAARKKPSLELELPSSPDSTGGTPKATLSDASDALQKNSNPYITPNNRYGHQNGASYAWHFEARKSQILKCMECGSSHDTLQELTAHMMVTGHFIKVTNSAMKKGKPIMETPVTPTITTLLDEKVQSVPLAATTFTSPSNTPASVSPKLAVEIKKEVDKEKAVPDEKPKEREKPSEEEEKYDISSKYHYLTENDLEESPKGGLDILKSLENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNMMKLSLGSSGKSTPLKPMFGNSEIVSPTKTQTLVSPPSSQTSPMPKTNFHAMEELVKKVTEKVAKVEEKMKEPEGKLSPPKRATPSPCSSEQSEPIKMEASSDGSFKSQENSPSPPRDACKEASPSAEPVENGKELVKPLSGGLSGSTAIITDHPPEQPFVNPLSALQSVMNIHLGKAAKPSLPALDPMSMLFKMSNSLAEKAAVATPPPLQAKKAEHLDRYFYHVNNDQPIDLTKGKSDKGCSLGSGLLSPTSTSPATSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESHTSKSSTPSSISEKSDIDGATLEEAEESTPAQKRKGRQSNWNPQHLLILQAQFAASLRQTSEGKYIMSDLSPQERMHISRFTGLSMTTISHWLANVKYQLRRTGGTKFLKNLDTGHPVFFCNDCASQIRTPSTYISHLESHLGFRLRDLSKLSTEQINNQIAQTKSPSEKLVTSSPEEDLGTTYQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLLFVSELEKQ
uniprot
proteins
function
FUNCTION: Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter. Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (PubMed:27668656). {ECO:0000269|PubMed:18776146, ECO:0000269|PubMed:19745106, ECO:0000269|PubMed:20631175, ECO:0000269|PubMed:27668656}.
uniprot
proteins
mass_dalton
118626
uniprot
proteins
protein_family
Teashirt C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
14973285
uniprot
proteins
pubmed
18776146
uniprot
proteins
pubmed
19343227
uniprot
proteins
pubmed
19745106
uniprot
proteins
pubmed
20631175
uniprot
proteins
pubmed
27668656
uniprot
proteins
sequence_length
1081
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. Cell projection, growth cone {ECO:0000250}. Note=Colocalizes with APBB1 in the nucleus. Colocalizes with APBB1 in axonal growth cone (By similarity). {ECO:0000250}.
uniprot
proteins