TPRX1
entrez
284355
canonical
uniprot
Q8N7U7
canonical
ensembl
ENSG00000178928
resolver
ensp
ENSP00000438832
resolver
ensp
ENSP00000513863
resolver
enst
ENST00000535759
resolver
enst
ENST00000698655
resolver
genesymbol
TPRX1
resolver
hgnc
HGNC:32174
resolver
uniprot
A0A8V8TMK4
resolver
uniprot
A5D8Y3
resolver
uniprot
B2RPL5
resolver
uniprot
D2CFI5
resolver
uniprot
F6S1Y5
resolver
uniprot_entry
A0A8V8TMK4_HUMAN
resolver
uniprot_entry
D2CFI5_HUMAN
resolver
uniprot_entry
F6S1Y5_HUMAN
resolver
uniprot_entry
TPRX1_HUMAN
resolver
uniprot_sec
A5D8Y3
resolver
uniprot_sec
B2RPL5
resolver
amino_acid_sequence
MLSLREQQLQVWFKNRRAKLARERRLQQQPQRVPGQRGRGARAAPLVPAASASAPQRGPSGILPAAEPTICSLHQAWGGPGCRAQKGIPAALSPGPGPIPAPIPGPAQIPGPLPGSIPGPIPGPAQIPSPIPAPIPGPISGPVQIPGPFRGPIPGPISGPAPIPGPISGPFSGPNPGPIPGPNPGPIPGPISGPIPGPISVPIPGPIPGPISGPISGPNPGPIPGPIPGPISGPNPGPIPGPISGPNPGLIPGPIPGPISGPGPIIGPIPSPAQIPGPGRLQGPGPILSPGRMRSPGSLPGLAPILGPGSGPGSGSVPAPIPGPGSLPAPAPLWPQSPDASDFLPDTQLFPHFTELLLPLDPLEGSSVSTMTSQYQEGDDSMGKKHSGSQPQEEGGSVNENHSGPRLLLDL
uniprot
proteins
function
FUNCTION: Transcription factor expressed after fertilization required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:35314832, PubMed:36074823). Binds and activates expression of key ZGA marker genes, such as NANOGNB, ZSCAN4, DUXB, KLF5 and DPPA3 (PubMed:36074823). Binds to regulatory DNA sequences containing a 5'-TAATCC-3' sequence motif (PubMed:36074823). {ECO:0000269|PubMed:35314832, ECO:0000269|PubMed:36074823}.
uniprot
proteins
mass_dalton
40603
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
35314832
uniprot
proteins
pubmed
36074823
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
uniprot
proteins