Cyp4a2
entrez
24306
canonical
uniprot
P20816
canonical
ensembl
ENSRNOG00000079980
resolver
ensembl
ENSRNOG00000082592
resolver
ensp
ENSRNOP00000100031
resolver
ensp
ENSRNOP00000112466
resolver
enst
ENSRNOT00000136926
resolver
genesymbol
Cyp4a2
resolver
genesymbol_syn
Cyp4a-2
resolver
genesymbol_syn
Cyp4a11
resolver
uniprot
Q4G071
resolver
uniprot_entry
CP4A2_RAT
resolver
uniprot_sec
Q4G071
resolver
amino_acid_sequence
MGFSVFSPTRSLDGVSGFFQGAFLLSLFLVLFKAVQFYLRRQWLLKALEKFPSTPSHWLWGHNLKDREFQQVLTWVEKFPGACLQWLSGSTARVLLYDPDYVKVVLGRSDPKPYQSLAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLDVNSRSYTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTDGVIKTRKAQLQNEEELQKARKKRHLDFLDILLFAKMEDGKSLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDGTSVTWDHLDQMPYTTMCIKEALRLYSPVPSVSRELSSPVTFPDGRSIPKGIRVTILIYGLHHNPSYWPNPKVFDPSRFSPDSPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNGIHLRLKKLR
uniprot
proteins
ec_number
1.14.14.80
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase that catalyzes omega and omega-1 hydroxylation of saturated fatty acids. Exhibits preferential omega versus omega-1 regioselectivity and (R) versus (S) stereoselectivity for hydroxylation of lauric and myristic acids (PubMed:10620324, PubMed:10869363). Has low activity toward palmitic acid (PubMed:10620324). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10620324, PubMed:10869363). {ECO:0000269|PubMed:10620324, ECO:0000269|PubMed:10869363}.
uniprot
proteins
mass_dalton
57969
uniprot
proteins
mutagenesis
MUTAGEN 116; /note="S->F: 2-fold decrease of omega/omega-1 hydroxylation ratio for lauric acid."; /evidence="ECO:0000269|PubMed:10869363
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000305|PubMed:10620324, ECO:0000305|PubMed:10869363}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10620324
uniprot
proteins
pubmed
10869363
uniprot
proteins
pubmed
11139583
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1739747
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2306108
uniprot
proteins
pubmed
2766932
uniprot
proteins
sequence_length
504
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
uniprot
proteins