Hbegf
entrez
25433
canonical
uniprot
Q06175
canonical
ensembl
ENSRNOG00000018646
resolver
ensembl
ENSRNOG00055023036
resolver
ensembl
ENSRNOG00060019965
resolver
ensembl
ENSRNOG00065012794
resolver
ensp
ENSRNOP00000025157
resolver
ensp
ENSRNOP00055032137
resolver
ensp
ENSRNOP00060028349
resolver
ensp
ENSRNOP00065016100
resolver
enst
ENSRNOT00000025157
resolver
enst
ENSRNOT00055039575
resolver
enst
ENSRNOT00060034525
resolver
enst
ENSRNOT00065020895
resolver
genesymbol
Hbegf
resolver
genesymbol_syn
Dtr
resolver
genesymbol_syn
Hegfl
resolver
uniprot_entry
HBEGF_RAT
resolver
amino_acid_sequence
MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAATSNPDPPTGTTNQLLPTGADRAQEVQDLEGTDLDLFKVAFSSKPQALATPGKEKNGKKKRKGKGLGKKRDPCLKKYKDYCIHGECRYLKELRIPSCHCLPGYHGQRCHGLTLPVENPLYTYDHTTVLAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDLESEEKVKLGMASSH
uniprot
proteins
function
FUNCTION: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
22843
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
7678488
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Heparin-binding EGF-like growth factor]: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor.; SUBCELLULAR LOCATION: [Proheparin-binding EGF-like growth factor]: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 161..184; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins