LRRC8B
entrez
23507
canonical
uniprot
Q6P9F7
canonical
ensembl
ENSG00000197147
resolver
ensp
ENSP00000332674
resolver
ensp
ENSP00000491377
resolver
ensp
ENSP00000492151
resolver
ensp
ENSP00000552855
resolver
ensp
ENSP00000645297
resolver
enst
ENST00000330947
resolver
enst
ENST00000639264
resolver
enst
ENST00000640258
resolver
enst
ENST00000882796
resolver
genesymbol
LRRC8B
resolver
genesymbol_syn
KIAA0231
resolver
hgnc
HGNC:30692
resolver
uniprot
A0A384N5V6
resolver
uniprot
D3DT28
resolver
uniprot
Q6UY21
resolver
uniprot
Q8N106
resolver
uniprot
Q92627
resolver
uniprot_entry
A0A384N5V6_HUMAN
resolver
uniprot_entry
LRC8B_HUMAN
resolver
uniprot_sec
D3DT28
resolver
uniprot_sec
Q6UY21
resolver
uniprot_sec
Q8N106
resolver
uniprot_sec
Q92627
resolver
amino_acid_sequence
MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKVEFDNHCAVPWDILKASMNTSSNPGTPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVRPLKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQTCLDKC
uniprot
proteins
function
FUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731}.
uniprot
proteins
mass_dalton
92390
uniprot
proteins
protein_family
LRRC8 family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22532330
uniprot
proteins
pubmed
24790029
uniprot
proteins
pubmed
26824658
uniprot
proteins
pubmed
28193731
uniprot
proteins
pubmed
9039502
uniprot
proteins
sequence_length
803
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:24790029}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane. {ECO:0000269|PubMed:24790029}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 262..282; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 308..328; /note="Helical; Name=4"; /evidence="ECO:0000255
uniprot
proteins