Cacfd1
entrez
381356
canonical
uniprot
Q8BG21
canonical
ensembl
ENSMUSG00000015488
resolver
ensp
ENSMUSP00000109637
resolver
ensp
ENSMUSP00000109638
resolver
ensp
ENSMUSP00000109639
resolver
genesymbol
Cacfd1
resolver
uniprot
A2AR22
resolver
uniprot
A2AR23
resolver
uniprot
A6PWX1
resolver
uniprot
Q8C9W0
resolver
uniprot
Q8CC30
resolver
uniprot
Q9CX69
resolver
uniprot_entry
FLOWR_MOUSE
resolver
uniprot_sec
A2AR22
resolver
uniprot_sec
A2AR23
resolver
uniprot_sec
A6PWX1
resolver
uniprot_sec
Q8C9W0
resolver
uniprot_sec
Q8CC30
resolver
uniprot_sec
Q9CX69
resolver
amino_acid_sequence
MSGSGAAGAAAGPAPPAQEEGMTWWYRWLCRLAGVLGAVSCAISGLFNCVTIHPLNIAAGVWMIMNAFILLLCEAPFCCQFVEFANTVAEKVDRLRSWQKAVFYCGMAIVPIVMSLTLTTLLGNAIAFATGVLYGLSALGKKGDAISYARIQQQRQQADEEKLAETFEGEL
uniprot
proteins
function
FUNCTION: Transmembrane protein which mediates synaptic endocytosis and fitness-based cell culling (PubMed:22362363, PubMed:29288152). In response to different stimulus strengths, controls two major modes of synaptic vesicle (SV) retrieval in hippocampal neurons; Clathrin-mediated endocytosis (CME) in response to mild stimulation and activity-dependent bulk endocytosis (ADBE) in response to strong stimulation (By similarity). In cytotoxic T-lymphocytes (CTLs) facilitates calcium-dependent endocytosis of cytotoxic granules (CGs) at the immuno synapse (PubMed:29288152). Different isoforms work as fitness fingerprints in 'loser' and 'winner' cells and thereby mediate win/lose decisions as part of the cell competition process (PubMed:22362363). {ECO:0000250|UniProtKB:D4A9I3, ECO:0000269|PubMed:22362363, ECO:0000269|PubMed:29288152}.
uniprot
proteins
mass_dalton
18343
uniprot
proteins
mutagenesis
MUTAGEN 26..29; /note="YRWL->AAAA: Reduces binding to AP-2 complexes and increases localization to plasma membrane; when associated with 148-A--A-151."; /evidence="ECO:0000269|PubMed:29288152"; MUTAGEN 148..151; /note="YARI->AAAA: Reduces binding to AP-2 complexes and increases localization to plasma membrane; when associated with 26-A--A-29."; /evidence="ECO:0000269|PubMed:29288152
uniprot
proteins
protein_family
Calcium channel flower family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22362363
uniprot
proteins
pubmed
28414717
uniprot
proteins
pubmed
29288152
uniprot
proteins
sequence_length
171
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29288152}; Multi-pass membrane protein {ECO:0000305}. Vesicle {ECO:0000269|PubMed:29288152}. Note=In cytotoxic T-lymphocytes, localizes to intracellular vesicles that move to the immuno synapse (PubMed:29288152). Enriched in synaptic vesicles at the presynaptic vesicles (By similarity). Detected in the Golgi apparatus of cultured hippocampal neurons (By similarity). {ECO:0000250|UniProtKB:D4A9I3, ECO:0000269|PubMed:29288152}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 57..77; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 125..141; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins