PTPA
entrez
5524
canonical
uniprot
Q15257
canonical
ensembl
ENSG00000119383
resolver
ensp
ENSP00000337448
resolver
ensp
ENSP00000347109
resolver
ensp
ENSP00000349726
resolver
ensp
ENSP00000377036
resolver
ensp
ENSP00000394338
resolver
ensp
ENSP00000588733
resolver
enst
ENST00000452489
resolver
genesymbol
PTPA
resolver
genesymbol_syn
PPP2R4
resolver
hgnc
HGNC:9308
resolver
uniprot
A2A347
resolver
uniprot
A9IZU4
resolver
uniprot
B4DXM4
resolver
uniprot
F6WIT2
resolver
uniprot
Q15258
resolver
uniprot
Q53GZ3
resolver
uniprot
Q5TZQ2
resolver
uniprot
Q9BUK1
resolver
uniprot
Q9NNZ7
resolver
uniprot
Q9NNZ8
resolver
uniprot
Q9NNZ9
resolver
uniprot_entry
F6WIT2_HUMAN
resolver
uniprot_entry
PTPA_HUMAN
resolver
uniprot_sec
A2A347
resolver
uniprot_sec
A9IZU4
resolver
uniprot_sec
B4DXM4
resolver
uniprot_sec
Q15258
resolver
uniprot_sec
Q53GZ3
resolver
uniprot_sec
Q5TZQ2
resolver
uniprot_sec
Q9BUK1
resolver
uniprot_sec
Q9NNZ7
resolver
uniprot_sec
Q9NNZ8
resolver
uniprot_sec
Q9NNZ9
resolver
amino_acid_sequence
MAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRVSEMWNEVHEEKEQAAKQSVSCDECIPLPRAGHCAPSEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPFIWGSSQLIDHPYLEPRHFVDEKAVNENHKDYMFLECILFITEMKTGPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVTSG
uniprot
proteins
disease_involvement
DISEASE: Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development (PARK25) [MIM:620482]: An autosomal recessive, early-onset form of Parkinson disease, a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK25 is characterized by onset of parkinsonism in late childhood or adolescence, developmental delay and intellectual disability. Cognitive impairment is mild to moderate and non-progressive. {ECO:0000269|PubMed:36073231}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
5.2.1.8
uniprot
proteins
function
FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) (PubMed:16916641, PubMed:36073231). Modulates PP2A activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase (PubMed:16916641). Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro) (PubMed:16916641). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex (PubMed:16916641). Is involved in apoptosis; the function appears to be independent from PP2A (PubMed:17333320). {ECO:0000250|UniProtKB:Q28717, ECO:0000269|PubMed:16916641, ECO:0000269|PubMed:17333320, ECO:0000269|PubMed:36073231}.
uniprot
proteins
mass_dalton
40668
uniprot
proteins
mutagenesis
MUTAGEN 185; /note="D->A: Impairs ATPase activity of the PP2A(D):PPP2R4 complex; no effect on interaction with the PP2A(D) complex."; /evidence="ECO:0000269|PubMed:16916641"; MUTAGEN 239; /note="A->D: Impairs ATPase activity of the PP2A(D):PPP2R4 complex; no effect on interaction with the PP2A(D) complex."; /evidence="ECO:0000269|PubMed:16916641"; MUTAGEN 240; /note="G->D: Impairs ATPase activity of the PP2A(D):PPP2R4 complex; no effect on interaction with the PP2A(D) complex."; /evidence="ECO:0000269|PubMed:16916641"; MUTAGEN 244; /note="V->D: Impairs interaction with the PP2A(D) complex."; /evidence="ECO:0000269|PubMed:16916641"; MUTAGEN 305; /note="E->A: Abolishes interaction with the PP2A(D) complex."; /evidence="ECO:0000269|PubMed:16916641"; MUTAGEN 316; /note="V->D: Impairs interaction with the PP2A(D) complex."; /evidence="ECO:0000269|PubMed:16916641"; MUTAGEN 325; /note="G->D: Abolishes interaction with the PP2A(D) complex."; /evidence="ECO:0000269|PubMed:16916641"; MUTAGEN 329; /note="M->D: Abolishes interaction with the PP2A(D) complex."; /evidence="ECO:0000269|PubMed:16916641"; MUTAGEN 337; /note="K->G: Impairs interaction with the PP2A(D) complex."; /evidence="ECO:0000269|PubMed:16916641
uniprot
proteins
protein_family
PTPA-type PPIase family
uniprot
proteins
pubmed
10880964
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16782712
uniprot
proteins
pubmed
16885030
uniprot
proteins
pubmed
16916641
uniprot
proteins
pubmed
17333320
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25003389
uniprot
proteins
pubmed
36073231
uniprot
proteins
pubmed
8195217
uniprot
proteins
pubmed
8530035
uniprot
proteins
sequence_length
358
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17333320}. Nucleus {ECO:0000269|PubMed:17333320}.
uniprot
proteins