Phyh
entrez
16922
canonical
uniprot
O35386
canonical
ensembl
ENSMUSG00000026664
resolver
ensp
ENSMUSP00000027975
resolver
enst
ENSMUST00000027975
resolver
genesymbol
Phyh
resolver
genesymbol_syn
Ln1
resolver
genesymbol_syn
Lnap1
resolver
genesymbol_syn
Pahx
resolver
uniprot
O08527
resolver
uniprot
Q3TPC7
resolver
uniprot_entry
PAHX_MOUSE
resolver
uniprot_entry
Q3TPC7_MOUSE
resolver
uniprot_sec
O08527
resolver
amino_acid_sequence
MNLTRAGARLQVLLGHLGRPSAPTIVAQPVSGLASPASFQPEQFQYTLDNNVLTLEQRKFYEENGFLVIKNLVSDDDIQRFRAEFERICREEVKPPGIVIMRDVALAKQDYMPSDRMVSKIQDFQEDEELFRYCLLPEILKYVECFTGPNIMALHGMLINKPPDVGKKTSRHPLHQDLHYFPFRPSNLIVCAWTAMEHIDRNNGCLVVLPGTHKGTLKPHDYPKWEGGVNKMYHGIQDYDPNSPRVHLVMEKGDTVFFHPLLIHGSGRNKTQGFRKAISCHFGSSDCQCIDVSGTSQENIAREVVEMAEKKYGFQGVMDFKDTWIFRSRLVKGERINI
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Phyh are the cause of lupus nephritis, a severe autoimmune disease. Phyh could be involved in a reaction against the progression of the disease, because its expression is low in the early stage of the disease in the renal cortex of MRL/lpr mice. {ECO:0000269|PubMed:8954131}.
uniprot
proteins
ec_number
1.14.11.18
uniprot
proteins
function
FUNCTION: Catalyzes the 2-hydroxylation of not only racemic phytanoyl-CoA and the isomers of 3-methylhexadecanoyl-CoA, but also a variety of other mono-branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon atoms) (By similarity). Does not hydroxylate long and very long straight chain acyl-CoAs or 2-methyl-and 4-methyl-branched acyl-CoAs (By similarity). {ECO:0000250|UniProtKB:O14832}.
uniprot
proteins
mass_dalton
38607
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism.
uniprot
proteins
protein_family
PhyH family
uniprot
proteins
pubmed
10686344
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
8954131
uniprot
proteins
pubmed
9326939
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:O14832}.
uniprot
proteins