Mprip
entrez
26936
canonical
uniprot
P97434
canonical
ensembl
ENSMUSG00000005417
resolver
ensp
ENSMUSP00000071081
resolver
ensp
ENSMUSP00000071914
resolver
ensp
ENSMUSP00000112072
resolver
ensp
ENSMUSP00000119422
resolver
ensp
ENSMUSP00000181693
resolver
ensp
ENSMUSP00000181694
resolver
ensp
ENSMUSP00000181695
resolver
ensp
ENSMUSP00000181702
resolver
ensp
ENSMUSP00000181709
resolver
ensp
ENSMUSP00000181710
resolver
ensp
ENSMUSP00000181728
resolver
ensp
ENSMUSP00000181756
resolver
ensp
ENSMUSP00000181774
resolver
ensp
ENSMUSP00000181782
resolver
enst
ENSMUST00000066330
resolver
genesymbol
Mprip
resolver
genesymbol_syn
Kiaa0864
resolver
genesymbol_syn
Mrip
resolver
genesymbol_syn
Rhoip3
resolver
uniprot
Q3TBR5
resolver
uniprot
Q3TC85
resolver
uniprot
Q3TRS0
resolver
uniprot
Q3U1Y8
resolver
uniprot
Q3U3E4
resolver
uniprot
Q5SWZ3
resolver
uniprot
Q5SWZ4
resolver
uniprot
Q5SWZ5
resolver
uniprot
Q5SWZ7
resolver
uniprot
Q6P559
resolver
uniprot
Q80YC8
resolver
uniprot_entry
MPRIP_MOUSE
resolver
uniprot_entry
Q5SWZ5_MOUSE
resolver
uniprot_sec
Q3TBR5
resolver
uniprot_sec
Q3TC85
resolver
uniprot_sec
Q3TRS0
resolver
uniprot_sec
Q3U1Y8
resolver
uniprot_sec
Q3U3E4
resolver
uniprot_sec
Q5SWZ3
resolver
uniprot_sec
Q5SWZ4
resolver
uniprot_sec
Q5SWZ7
resolver
uniprot_sec
Q6P559
resolver
uniprot_sec
Q80YC8
resolver
amino_acid_sequence
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEARTGQKFSLCILTPDKEHFIRAETKEIISGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKMAVTSSSGGSSGSSSSIPSAEKVPTTKSTLWQEEMRAKDQPDGTSLSPAQSPSQSQPPAACTPREPGLESKEDESTISGDRVDGGRKVRVESGYFSLEKAKQDLRAEEQLPPLLSPPSPSTPHSRRSQVIEKFEALDIEKAEHMETNMLILTTPSSDTRQGRSERRAIPRKRDFASEAPTAPLSDACPLSPHRRAKSLDRRSTESSMTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRDSVAEEAADLDGEINLSTCYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVLPASAPDVTSSLPEGKNKSTSFETCSRSTEKQEAEPGEPDPEQKKSRARERRREGRSKTFDWAEFRPIQQALAQERASAVGSSDSGDPGCLEAEPGELERERARRREERRKRFGMLDTIDGPGMEDTALRMDIDRSPGLLGTPDLKTQNVHVEIEQRWHQVETTPLREEKQVPIAPLHLSLEDRSERLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSINSDIEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGESTGLPLTQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEKSPEGTTVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSVIEQVSWDN
uniprot
proteins
function
FUNCTION: Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000269|PubMed:12732640, ECO:0000269|PubMed:15469989}.
uniprot
proteins
mass_dalton
116408
uniprot
proteins
mutagenesis
MUTAGEN 857; /note="L->P: Loss of interaction with PPP1R12C and PPP1R12A."; /evidence="ECO:0000269|PubMed:15469989"; MUTAGEN 905; /note="L->P: No effect."; /evidence="ECO:0000269|PubMed:15469989"; MUTAGEN 919; /note="I->P: Loss of interaction with PPP1R12C and PPP1R12A."; /evidence="ECO:0000269|PubMed:15469989
uniprot
proteins
pubmed
12732640
uniprot
proteins
pubmed
15469989
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20093627
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9199174
uniprot
proteins
sequence_length
1024
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12732640}. Note=Colocalizes with F-actin.
uniprot
proteins