Oaz1
entrez
18245
canonical
uniprot
P54369
canonical
ensembl
ENSMUSG00000035242
resolver
ensp
ENSMUSP00000136469
resolver
ensp
ENSMUSP00000137400
resolver
enst
ENSMUST00000180036
resolver
genesymbol
Oaz1
resolver
genesymbol_syn
Oaz
resolver
uniprot
O08610
resolver
uniprot_entry
OAZ1_MOUSE
resolver
uniprot_sec
O08610
resolver
amino_acid_sequence
MVKSSLQRILNSHCFAREKEGDKRSATLHASRTMPLLSQHSRGGCSSESSRVALNCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHSLSASILYSDERLNVTEEPTSNDKTRVLSIQSTLTEAKQVTWRAVWSGGGLYIELPAGPLPEGSKDSFAALLEFAEEQLQADHVFICFPKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMVYTLEREDPGEED
uniprot
proteins
function
FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:16916800, PubMed:18508777). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (By similarity). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:18062773). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338). {ECO:0000250|UniProtKB:P54368, ECO:0000269|PubMed:16916800, ECO:0000269|PubMed:18062773, ECO:0000269|PubMed:18508777, ECO:0000269|PubMed:19449338}.
uniprot
proteins
mass_dalton
25133
uniprot
proteins
protein_family
ODC antizyme family
uniprot
proteins
pubmed
16916800
uniprot
proteins
pubmed
18062773
uniprot
proteins
pubmed
18508777
uniprot
proteins
pubmed
19449338
uniprot
proteins
pubmed
24967154
uniprot
proteins
pubmed
9428668
uniprot
proteins
sequence_length
227
uniprot
proteins