Ccnb1ip1
entrez
239083
canonical
uniprot
D3Z3K2
canonical
ensembl
ENSMUSG00000071470
resolver
ensp
ENSMUSP00000093622
resolver
enst
ENSMUST00000095932
resolver
genesymbol
Ccnb1ip1
resolver
genesymbol_syn
Gm288
resolver
genesymbol_syn
Hei10
resolver
genesymbol_syn
Mei4
resolver
uniprot_entry
CIP1_MOUSE
resolver
amino_acid_sequence
MSLCEDMLLCNYRKCRIKLSGYAWVTACSHIFCDQHGSGEFSRSPAICPACNSTLSGKLDIVRTELSPSEEYKAMVLAGLRPEVVLDISSRALAFWTYQVHQERLYQEYNFSKAENHLKQMEKMYMQQIQSKNIELTSMKGEVISMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIASQEGSLEPGMIPQSGVFGFPPGNNSKFSLDHIPVGNQGGGDEDVQFRPFFVCSPTAPEPINNFFSFASPSHEAEQQVCSRAFKAKRI
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. {ECO:0000269|PubMed:17784788, ECO:0000269|PubMed:24390283}.
uniprot
proteins
mass_dalton
31386
uniprot
proteins
mutagenesis
MUTAGEN 77..100; /note="Missing: In mei4; Sterility in both sexes due to meiotic defects.
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; autoubiquitinated. {ECO:0000250}.; PTM: Phosphorylated by CDK1 on serine or threonine residues (in vitro). {ECO:0000250}.
uniprot
proteins
pubmed
17784788
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21779533
uniprot
proteins
pubmed
24390283
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24390283}. Chromosome {ECO:0000269|PubMed:24390283}. Note=Associates to the synaptonemal complex.
uniprot
proteins