LAP3
entrez
51056
canonical
uniprot
P28838
canonical
ensembl
ENSG00000002549
resolver
ensp
ENSP00000226299
resolver
genesymbol
LAP3
resolver
genesymbol_syn
LAPEP
resolver
genesymbol_syn
PEPS
resolver
hgnc
HGNC:18449
resolver
uniprot
B3KMQ3
resolver
uniprot
Q6IAM6
resolver
uniprot
Q6P0L6
resolver
uniprot
Q9UQE3
resolver
uniprot_entry
AMPL_HUMAN
resolver
uniprot_sec
B3KMQ3
resolver
uniprot_sec
Q6IAM6
resolver
uniprot_sec
Q6P0L6
resolver
uniprot_sec
Q9UQE3
resolver
amino_acid_sequence
MFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQDFPSVVLVGLGKKAAGIDEQENWHEGKENIRAAVAAGCRQIQDLELSSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKMAVSAKLYGSGDQEAWQKGVLFASGQNLARQLMETPANEMTPTRFAEIIEKNLKSASSKTEVHIRPKSWIEEQAMGSFLSVAKGSDEPPVFLEIHYKGSPNANEPPLVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMTGRPTRTLIEFLLRFSQDNA
uniprot
proteins
ec_number
3.4.11.1
uniprot
proteins
ec_number
3.4.11.5
uniprot
proteins
ec_number
3.4.13.23
uniprot
proteins
function
FUNCTION: Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. {ECO:0000250|UniProtKB:P00727}.
uniprot
proteins
mass_dalton
56166
uniprot
proteins
protein_family
Peptidase M17 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1908238
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q68FS4}.
uniprot
proteins