KCNH4
entrez
23415
canonical
uniprot
Q9UQ05
canonical
ensembl
ENSG00000089558
resolver
ensp
ENSP00000264661
resolver
ensp
ENSP00000475564
resolver
enst
ENST00000264661
resolver
enst
ENST00000607371
resolver
genesymbol
KCNH4
resolver
hgnc
HGNC:6253
resolver
uniprot_entry
KCNH4_HUMAN
resolver
amino_acid_sequence
MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEVMQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEMGEVVLFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLTGHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEAPSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRELRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASRPPPSLQDTTLAEVHCPASVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASPPTPSLLRHSFQSRSDTFH
uniprot
proteins
function
FUNCTION: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier (PubMed:10455180). Activates at more negative voltages, exhibits fast prepulse-independent activation kinetics and deactivates much more slowly, but shows no inactivation (By similarity). {ECO:0000250|UniProtKB:Q9R1T9, ECO:0000269|PubMed:10455180}.
uniprot
proteins
mass_dalton
111693
uniprot
proteins
protein_family
H (Eag) (TC 1.A.1.20) subfamily
uniprot
proteins
protein_family
Kv12.3/KCNH4 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10455180
uniprot
proteins
pubmed
16959974
uniprot
proteins
sequence_length
1017
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 229..249; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 303..323; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 333..353; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 483..503; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins