GMDS
entrez
2762
canonical
uniprot
O60547
canonical
ensembl
ENSG00000112699
resolver
ensp
ENSP00000370194
resolver
ensp
ENSP00000436726
resolver
ensp
ENSP00000714667
resolver
ensp
ENSP00000779066
resolver
genesymbol
GMDS
resolver
hgnc
HGNC:4369
resolver
uniprot
E9PI88
resolver
uniprot
O75357
resolver
uniprot
Q5T954
resolver
uniprot
Q6FH09
resolver
uniprot
Q9UGZ3
resolver
uniprot
Q9UJK9
resolver
uniprot_entry
GMDS_HUMAN
resolver
uniprot_sec
E9PI88
resolver
uniprot_sec
O75357
resolver
uniprot_sec
Q5T954
resolver
uniprot_sec
Q6FH09
resolver
uniprot_sec
Q9UGZ3
resolver
uniprot_sec
Q9UJK9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by GDP-fucose. {ECO:0000269|PubMed:9525924}.
uniprot
proteins
amino_acid_sequence
MAHAPARCPSARGSGDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVHADVELMRTNPNA
uniprot
proteins
ec_number
4.2.1.47
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. {ECO:0000269|PubMed:9525924, ECO:0000269|PubMed:9603974}.
uniprot
proteins
mass_dalton
41950
uniprot
proteins
pathway_participation
PATHWAY: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2. {ECO:0000305|PubMed:9525924}.
uniprot
proteins
protein_family
6-dehydratase subfamily
uniprot
proteins
protein_family
GDP-mannose 4
uniprot
proteins
protein_family
NAD(P)-dependent epimerase/dehydratase family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9525924
uniprot
proteins
pubmed
9603974
uniprot
proteins
sequence_length
372
uniprot
proteins