MMP24
entrez
10893
canonical
uniprot
Q9Y5R2
canonical
ensembl
ENSG00000125966
resolver
ensp
ENSP00000246186
resolver
ensp
ENSP00000597374
resolver
ensp
ENSP00000597375
resolver
enst
ENST00000246186
resolver
genesymbol
MMP24
resolver
genesymbol_syn
MT5MMP
resolver
hgnc
HGNC:7172
resolver
uniprot
B7ZBG8
resolver
uniprot
Q86VV6
resolver
uniprot
Q9H440
resolver
uniprot_entry
MMP24_HUMAN
resolver
uniprot_entry
Q86VV6_HUMAN
resolver
uniprot_sec
B7ZBG8
resolver
uniprot_sec
Q9H440
resolver
amino_acid_sequence
MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAGNRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV
uniprot
proteins
ec_number
3.4.24.-
uniprot
proteins
function
FUNCTION: Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
73231
uniprot
proteins
post_translational_modification
PTM: Cleaved by a furin endopeptidase in the trans-Golgi network. {ECO:0000250}.
uniprot
proteins
protein_family
Peptidase M10A family
uniprot
proteins
pubmed
10363975
uniprot
proteins
pubmed
11780052
uniprot
proteins
sequence_length
645
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Matrix metalloproteinase-24]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3. {ECO:0000250}.; SUBCELLULAR LOCATION: [Processed matrix metalloproteinase-24]: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Also shed from cell surface as soluble proteinase, by a proteolytic cleavage. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 603..623; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins