Atp1b1
entrez
25650
canonical
uniprot
P07340
canonical
ensembl
ENSRNOG00000002934
resolver
ensembl
ENSRNOG00055017745
resolver
ensembl
ENSRNOG00060009545
resolver
ensembl
ENSRNOG00065019205
resolver
ensp
ENSRNOP00000003932
resolver
ensp
ENSRNOP00055024118
resolver
ensp
ENSRNOP00060012647
resolver
ensp
ENSRNOP00065025830
resolver
enst
ENSRNOT00000003932
resolver
enst
ENSRNOT00055030026
resolver
enst
ENSRNOT00060016167
resolver
enst
ENSRNOT00065032323
resolver
genesymbol
Atp1b1
resolver
uniprot
Q63062
resolver
uniprot_entry
AT1B1_RAT
resolver
uniprot_sec
Q63062
resolver
amino_acid_sequence
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISELKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIIRFLEKYKDSAQKDDMIFEDCGSMPSEPKERGEFNHERGERKVCRFKLDWLGNCSGLNDESYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPLTMKYNPNVLPVQCTGKRDEDKDKVGNIEYFGMGGFYGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTLDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. The beta subunit is important for the folding, stability, and targeting of the Na(+)/K(+)-ATPase pump to the plasma membranes (By similarity). In addition, acts as a homotypic cell adhesion molecule in epithelia cells. Interactions between ATP1B1 on neighboring cells are critical for proper lateral polarization of the Na(+)/K(+)-ATPase pump and for stabilizing cell-cell adhesion (PubMed:22328500). Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (By similarity). {ECO:0000250|UniProtKB:P05026, ECO:0000250|UniProtKB:Q91580, ECO:0000269|PubMed:22328500}.
uniprot
proteins
mass_dalton
35202
uniprot
proteins
post_translational_modification
PTM: Glutathionylated (By similarity). N-glycosylated (PubMed:14749213). N-glycosylation promotes the stability of ATP1B1 homotypic interactions (PubMed:22328500). {ECO:0000250|UniProtKB:P14094, ECO:0000269|PubMed:14749213, ECO:0000269|PubMed:22328500}.; PTM: Ubiquitinated by RNF183 leading to its lysosomal degradation. {ECO:0000250|UniProtKB:P05026}.
uniprot
proteins
protein_family
X(+)/potassium ATPases subunit beta family
uniprot
proteins
pubmed
1314096
uniprot
proteins
pubmed
14749213
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15743908
uniprot
proteins
pubmed
22328500
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23532852
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
3025616
uniprot
proteins
pubmed
3031033
uniprot
proteins
pubmed
36085139
uniprot
proteins
pubmed
37482134
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P05026}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P05027}. Apical cell membrane {ECO:0000269|PubMed:14749213}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P05027}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P14094}. Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines. {ECO:0000250|UniProtKB:P14094}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..62; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000250|UniProtKB:P05027
uniprot
proteins