CASP8AP2
entrez
9994
canonical
uniprot
Q9UKL3
canonical
ensembl
ENSG00000118412
resolver
ensembl
ENSG00000288475
resolver
ensp
ENSP00000478179
resolver
ensp
ENSP00000518371
resolver
ensp
ENSP00000518847
resolver
enst
ENST00000671703
resolver
enst
ENST00000713552
resolver
genesymbol
CASP8AP2
resolver
genesymbol_syn
FLASH
resolver
genesymbol_syn
KIAA1315
resolver
genesymbol_syn
RIP25
resolver
hgnc
HGNC:1510
resolver
uniprot
A2RUB7
resolver
uniprot
E1P553
resolver
uniprot
Q6PH76
resolver
uniprot
Q7LCQ7
resolver
uniprot
Q86YD9
resolver
uniprot
Q9NUQ4
resolver
uniprot
Q9NZV9
resolver
uniprot
Q9P2N1
resolver
uniprot
Q9Y563
resolver
uniprot_entry
C8AP2_HUMAN
resolver
uniprot_sec
A2RUB7
resolver
uniprot_sec
E1P553
resolver
uniprot_sec
Q6PH76
resolver
uniprot_sec
Q7LCQ7
resolver
uniprot_sec
Q86YD9
resolver
uniprot_sec
Q9NUQ4
resolver
uniprot_sec
Q9NZV9
resolver
uniprot_sec
Q9P2N1
resolver
uniprot_sec
Q9Y563
resolver
amino_acid_sequence
MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEEILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLLVRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTDVSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSEDNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDNSVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVSADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTSSLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLIKHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLDYLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSEDPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPSTPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQGSDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWSLLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDLAVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSMMPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQTQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLPNTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDLTQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTESPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEKTKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIKKKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSKCR
uniprot
proteins
function
FUNCTION: Participates in TNF-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B (PubMed:12477726, PubMed:15698540). Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation (PubMed:12477726, PubMed:15698540). Involved in TNF-induced activation of NF-kappa-B via a TRAF2-dependent pathway (By similarity). Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B (PubMed:17245429). Required for the activation of CASP8 in FAS-mediated apoptosis (PubMed:17245429). Involved for histone gene transcription and progression through S phase: required for the generation of mature histone mRNAs following the 3' end cleavage of histone pre-mRNAs (PubMed:17003125, PubMed:19854135, PubMed:32367068). {ECO:0000250|UniProtKB:Q9WUF3, ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:19854135, ECO:0000269|PubMed:32367068}.
uniprot
proteins
mass_dalton
222658
uniprot
proteins
pubmed
10537104
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12477726
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15698540
uniprot
proteins
pubmed
17003125
uniprot
proteins
pubmed
17245429
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
19546234
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19854135
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23086935
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
32367068
uniprot
proteins
sequence_length
1982
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Note=Exported from the nucleus to the mitochondria upon FAS activation.
uniprot
proteins