Krt18
entrez
294853
canonical
uniprot
Q5BJY9
canonical
ensembl
ENSRNOG00000047393
resolver
ensembl
ENSRNOG00055026600
resolver
ensembl
ENSRNOG00060014085
resolver
ensembl
ENSRNOG00065020251
resolver
ensp
ENSRNOP00000111587
resolver
ensp
ENSRNOP00055037663
resolver
ensp
ENSRNOP00060019242
resolver
ensp
ENSRNOP00065027373
resolver
enst
ENSRNOT00000134417
resolver
enst
ENSRNOT00055045933
resolver
enst
ENSRNOT00060024125
resolver
enst
ENSRNOT00065034194
resolver
genesymbol
Krt18
resolver
genesymbol_syn
Krt1-18
resolver
uniprot
Q63278
resolver
uniprot_entry
K1C18_RAT
resolver
uniprot_sec
Q63278
resolver
amino_acid_sequence
MSFTTRSTTFSTNYRSLGSVRTPSQRVRPASSAASVYAGAGGSGSRISVSRSVWGGSVGSAGLAGMGGVQTEKETMQDLNDRLASYLDKVKNLETENRRLESKIREYLEKRGPQGVRDWGHYFKTIEDLRAQIFANSVDNARIVLQIDNARLAADDFRVKYETELAMRQSVESDIHGLRKVVDDTNITRLQLETEIEALKEELLFMKKNHEEEVQGLEAQIASSGLTVEVDAPKSQDLSKIMADIRAQYEQLAQKNREELDKYWSQQIEESTTVVTTKSAEIRDAETTLLELRRTLQTLEIDLDSMKNQNINLENNLGEVEARYRVQMEQLNGVLLHLESELAQTRAEGQRQTQEYEALLNIKVKLEAEIATYRRLLEDGDDFSLNDALDSSNSMQTVQRTTTRKVVDGKVVSETNDTRVLRH
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in simple epithelial cells. Forms intermediate filaments by heterodimerizing with the type II keratin KRT8, providing mechanical stability and resilience to epithelial cells (PubMed:1691189). Involved in ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement (By similarity). Integrates into the intermediate filament network of skeletal muscle fibers alongside desmin and KRT19, contributing to force transmission (By similarity). Organization and orientation of KRT18 filaments are responsible for the properly elongated morphology of epithelial tubules (By similarity). Also acts downstream of ROCK kinase activation as part of a positive feedback mechanism in response to cellular mechanical stress loading (By similarity). Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (PubMed:9353322). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection (By similarity). {ECO:0000250|UniProtKB:A0A8I3PJ84, ECO:0000250|UniProtKB:P05783, ECO:0000250|UniProtKB:P05784, ECO:0000269|PubMed:1691189, ECO:0000269|PubMed:9353322}.
uniprot
proteins
mass_dalton
47761
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-35 increases during mitosis. Phosphorylation increases by IL-6. {ECO:0000250|UniProtKB:P05783}.; PTM: Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-231 by either caspase-3, caspase-6 or caspase-7 (By similarity). {ECO:0000250}.; PTM: Dephosphorylated by ethanol. {ECO:0000269|PubMed:8824732}.; PTM: O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation. {ECO:0000250}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
10707864
uniprot
proteins
pubmed
11428046
uniprot
proteins
pubmed
14630065
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16128803
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
1691189
uniprot
proteins
pubmed
16998620
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7507868
uniprot
proteins
pubmed
7514933
uniprot
proteins
pubmed
7517927
uniprot
proteins
pubmed
7589899
uniprot
proteins
pubmed
8541209
uniprot
proteins
pubmed
8789401
uniprot
proteins
pubmed
8824732
uniprot
proteins
pubmed
9353322
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:16128803, ECO:0000269|PubMed:16998620}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P05783}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P05783}. Cytoplasm {ECO:0000269|PubMed:16128803, ECO:0000269|PubMed:16998620}.
uniprot
proteins