EML3
entrez
256364
canonical
uniprot
Q32P44
canonical
ensembl
ENSG00000149499
resolver
ensp
ENSP00000278845
resolver
ensp
ENSP00000378254
resolver
ensp
ENSP00000378256
resolver
ensp
ENSP00000433417
resolver
ensp
ENSP00000434513
resolver
ensp
ENSP00000435064
resolver
ensp
ENSP00000529441
resolver
enst
ENST00000278845
resolver
genesymbol
EML3
resolver
hgnc
HGNC:26666
resolver
uniprot
B4DL97
resolver
uniprot
B7WPE2
resolver
uniprot
Q6ZQW7
resolver
uniprot
Q8NA55
resolver
uniprot_entry
B4DL97_HUMAN
resolver
uniprot_entry
B7WPE2_HUMAN
resolver
uniprot_entry
EMAL3_HUMAN
resolver
uniprot_sec
Q6ZQW7
resolver
uniprot_sec
Q8NA55
resolver
amino_acid_sequence
MDGAAGPGDGPAREALQSLSQRLRVQEQEMELVKAALAEALRLLRLQVPPSSLQGSGTPAPPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNGPPAPQGASEEPSGTQSEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRNSSSSSSPSERPRQKLSRKAISSANLLVRSGSTESRGGKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPITMYIPSGIRSLEELPSGPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEGNILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQWRVLGAGGAGPAPATPSRTPSLSPASSLDV
uniprot
proteins
function
FUNCTION: Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}.
uniprot
proteins
mass_dalton
95197
uniprot
proteins
mutagenesis
MUTAGEN 881; /note="T->A: Loss of phosphorylation and impaired interaction with TUBG1, HAUS2, HAUS3, HAUS4, HAUS5, HAUS6, HAUS7 and HAUS8."; /evidence="ECO:0000269|PubMed:30723163"; MUTAGEN 883; /note="S->A: No loss of phosphorylation."; /evidence="ECO:0000269|PubMed:30723163"; MUTAGEN 889; /note="S->A: No loss of phosphorylation."; /evidence="ECO:0000269|PubMed:30723163
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-881 during mitosis is required for interaction with TUBG1, HAUS1, HAUS2, HAUS3, HAUS4, HAUS5, HAUS6, HAUS7 and HAUS8 and their recruitment to spindle microtubules. {ECO:0000269|PubMed:30723163}.
uniprot
proteins
protein_family
WD repeat EMAP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18445686
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25740311
uniprot
proteins
pubmed
30723163
uniprot
proteins
sequence_length
896
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18445686, ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:18445686}. Nucleus {ECO:0000269|PubMed:18445686}. Midbody {ECO:0000269|PubMed:18445686}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}. Note=Localizes to microtubules throughout all mitotic stages and localizes to the midbody during cytokinesis. {ECO:0000269|PubMed:18445686}.
uniprot
proteins