Dtd1
entrez
66044
canonical
uniprot
Q9DD18
canonical
ensembl
ENSMUSG00000027430
resolver
ensp
ENSMUSP00000028917
resolver
genesymbol
Dtd1
resolver
genesymbol_syn
Hars2
resolver
uniprot
A2ANA2
resolver
uniprot
Q3TY44
resolver
uniprot
Q9CRE8
resolver
uniprot
Q9CYL0
resolver
uniprot
Q9D013
resolver
uniprot
Q9D1G4
resolver
uniprot_entry
DTD1_MOUSE
resolver
uniprot_sec
A2ANA2
resolver
uniprot_sec
Q3TY44
resolver
uniprot_sec
Q9CRE8
resolver
uniprot_sec
Q9CYL0
resolver
uniprot_sec
Q9D013
resolver
uniprot_sec
Q9D1G4
resolver
amino_acid_sequence
MKAVVQRVTRASVTVGGEQISAIGRGICVLLGISMEDSQKELEHMVRKILNLRVFEDESGKHWSKSVMDKEYEVLCVSQFTLQCVLKGNKPDFHLAMPTEQAESFYNSFLEQLRKSYRPELIRDGKFGAYMQVHIQNDGPVTIELESPAPGAASSDPKQLSKLEKQQQRKEKTRAKGPSESSKERNAPRKEDRSASSGAEGDVSSEREP
uniprot
proteins
ec_number
3.1.1.96
uniprot
proteins
function
FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000250|UniProtKB:Q8IIS0}.; FUNCTION: ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. {ECO:0000250|UniProtKB:Q8TEA8}.
uniprot
proteins
mass_dalton
23384
uniprot
proteins
post_translational_modification
PTM: Preferentially phosphorylated in cells arrested early in S phase. Phosphorylation in the C-terminus weakens the interaction with CDC45 (By similarity). {ECO:0000250|UniProtKB:Q8TEA8}.
uniprot
proteins
protein_family
DTD family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TEA8}. Cytoplasm {ECO:0000250|UniProtKB:Q8IIS0}. Note=Associated with chromatin at some replication origins containing functional DNA-unwinding elements (By similarity). {ECO:0000250|UniProtKB:Q8TEA8}.
uniprot
proteins