EIF3L
entrez
51386
canonical
uniprot
Q9Y262
canonical
ensembl
ENSG00000100129
resolver
ensp
ENSP00000371099
resolver
ensp
ENSP00000384634
resolver
ensp
ENSP00000499067
resolver
ensp
ENSP00000767503
resolver
enst
ENST00000406934
resolver
genesymbol
EIF3L
resolver
genesymbol
EIF3S6IP
resolver
genesymbol_syn
EIF3EIP
resolver
genesymbol_syn
EIF3S6IP
resolver
hgnc
HGNC:18138
resolver
uniprot
A0A024R1K4
resolver
uniprot
B0QY90
resolver
uniprot
B2RDG6
resolver
uniprot
B3KSH5
resolver
uniprot
B4DYB2
resolver
uniprot
G8JLH4
resolver
uniprot
Q53HQ1
resolver
uniprot
Q53HT4
resolver
uniprot
Q5QTR1
resolver
uniprot
Q5TI15
resolver
uniprot
Q6ICD2
resolver
uniprot_entry
B0QY90_HUMAN
resolver
uniprot_entry
B3KSH5_HUMAN
resolver
uniprot_entry
EIF3L_HUMAN
resolver
uniprot_sec
A0A024R1K4
resolver
uniprot_sec
B2RDG6
resolver
uniprot_sec
B4DYB2
resolver
uniprot_sec
G8JLH4
resolver
uniprot_sec
Q53HQ1
resolver
uniprot_sec
Q53HT4
resolver
uniprot_sec
Q5QTR1
resolver
uniprot_sec
Q5TI15
resolver
uniprot_sec
Q6ICD2
resolver
amino_acid_sequence
MSYPADDYESEAAYDPYAYPSDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIKNFIQYFHKTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAPQVGNDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIHLQLREKYGDKMLRMQKGDPQVYEELFSYSCPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLDLTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKFEELNRTLKKMGQRP
uniprot
proteins
function
FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03011, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
uniprot
proteins
mass_dalton
66727
uniprot
proteins
protein_family
EIF-3 subunit L family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11590142
uniprot
proteins
pubmed
12393749
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15703437
uniprot
proteins
pubmed
16322461
uniprot
proteins
pubmed
16766523
uniprot
proteins
pubmed
17322308
uniprot
proteins
pubmed
17581632
uniprot
proteins
pubmed
18056426
uniprot
proteins
pubmed
18599441
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25849773
uniprot
proteins
pubmed
27462815
uniprot
proteins
sequence_length
564
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.
uniprot
proteins