GID4
entrez
79018
canonical
uniprot
Q8IVV7
canonical
ensembl
ENSG00000141034
resolver
ensp
ENSP00000268719
resolver
ensp
ENSP00000365523
resolver
ensp
ENSP00000791464
resolver
enst
ENST00000268719
resolver
enst
ENST00000376345
resolver
genesymbol
GID4
resolver
genesymbol_syn
C17orf39
resolver
genesymbol_syn
VID24
resolver
hgnc
HGNC:28453
resolver
uniprot
B3KXL6
resolver
uniprot
K4DI96
resolver
uniprot
Q8TEB5
resolver
uniprot
Q9BW50
resolver
uniprot_entry
B3KXL6_HUMAN
resolver
uniprot_entry
GID4_HUMAN
resolver
uniprot_entry
K4DI96_HUMAN
resolver
uniprot_sec
Q8TEB5
resolver
uniprot_sec
Q9BW50
resolver
amino_acid_sequence
MCARGQVGRGTQLRTGRPCSQVPGSRWRPERLLRRQRAGGRPSRPHPARARPGLSLPATLLGSRAAAAVPLPLPPALAPGDPAMPVRTECPPPAGASAASAASLIPPPPINTQQPGVATSLLYSGSKFRGHQKSKGNSYDVEVVLQHVDTGNSYLCGYLKIKGLTEEYPTLTTFFEGEIISKKHPFLTRKWDADEDVDRKHWGKFLAFYQYAKSFNSDDFDYEELKNGDYVFMRWKEQFLVPDHTIKDISGASFAGFYYICFQKSAASIEGYYYHRSSEWYQSLNLTHVPEHSAPIYEFR
uniprot
proteins
function
FUNCTION: Substrate-recognition subunit of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (Probable) (PubMed:29911972). Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly-Leu-Trp (PubMed:29632410). Binds peptides with an N-terminal sequence of the type Pro-[Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind peptides with an acetylated N-terminal Pro residue (PubMed:29632410). {ECO:0000269|PubMed:29632410, ECO:0000269|PubMed:29911972, ECO:0000305}.
uniprot
proteins
mass_dalton
33514
uniprot
proteins
mutagenesis
MUTAGEN 132; /note="Q->A: Loss of interaction with peptides with a Pro/N-degron."; /evidence="ECO:0000269|PubMed:29632410"; MUTAGEN 237; /note="E->A: Loss of interaction with peptides with a Pro/N-degron."; /evidence="ECO:0000269|PubMed:29632410"; MUTAGEN 253; /note="S->D: Strongly decreased affinity for peptides with a Pro/N-degron."; /evidence="ECO:0000269|PubMed:29632410"; MUTAGEN 258; /note="Y->A: Loss of interaction with peptides with a Pro/N-degron."; /evidence="ECO:0000269|PubMed:29632410"; MUTAGEN 273; /note="Y->A: Loss of interaction with peptides with a Pro/N-degron."; /evidence="ECO:0000269|PubMed:29632410"; MUTAGEN 282; /note="Q->A: Loss of interaction with peptides with a Pro/N-degron."; /evidence="ECO:0000269|PubMed:29632410
uniprot
proteins
protein_family
GID4/VID24 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
29632410
uniprot
proteins
pubmed
29911972
uniprot
proteins
pubmed
38773330
uniprot
proteins
sequence_length
300
uniprot
proteins