PELI3
entrez
246330
canonical
uniprot
Q8N2H9
canonical
ensembl
ENSG00000174516
resolver
ensp
ENSP00000309848
resolver
ensp
ENSP00000322532
resolver
ensp
ENSP00000484220
resolver
ensp
ENSP00000574668
resolver
ensp
ENSP00000642087
resolver
genesymbol
PELI3
resolver
hgnc
HGNC:30010
resolver
uniprot
Q8N3E1
resolver
uniprot
Q8N9Q6
resolver
uniprot
Q8TAW7
resolver
uniprot
Q8TED5
resolver
uniprot_entry
PELI3_HUMAN
resolver
uniprot_sec
Q8N3E1
resolver
uniprot_sec
Q8N9Q6
resolver
uniprot_sec
Q8TAW7
resolver
uniprot_sec
Q8TED5
resolver
amino_acid_sequence
MVLEGNPEVGSPRTSDLQHRGNKGSCVLSSPGEDAQPGEEPIKYGELIVLGCCEEGGEETEAQRGEVTGPRAHSCYNGCLASGDKGRRRSRLALSRRSHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDTDMFQIGRSTENMIDFVVTDTSPGGGAAEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGCVRLIFQGPLD
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:12874243, PubMed:17675297). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 (PubMed:12874243). Mediates 'Lys-63'-linked polyubiquitination of IRAK1 (PubMed:12874243). Can activate AP1/JUN and ELK1 (PubMed:12874243). Acts as a regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (By similarity). Catalyzes 'Lys-63'-linked polyubiquitination of RIPK2 in parallel of XIAP (By similarity). {ECO:0000250|UniProtKB:Q8BXR6, ECO:0000269|PubMed:12874243, ECO:0000269|PubMed:17675297}.
uniprot
proteins
mass_dalton
50755
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:12874243, ECO:0000269|PubMed:17675297}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by IRAK1 enhancing its E3 ligase activity. {ECO:0000269|PubMed:17997719}.
uniprot
proteins
protein_family
Pellino family
uniprot
proteins
pubmed
12874243
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17675297
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
17997719
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
469
uniprot
proteins