Noc4l
entrez
360828
canonical
uniprot
Q5I0I8
canonical
ensembl
ENSRNOG00000037478
resolver
ensembl
ENSRNOG00060005810
resolver
ensp
ENSRNOP00000053566
resolver
ensp
ENSRNOP00060007247
resolver
enst
ENSRNOT00000056725
resolver
enst
ENSRNOT00060009640
resolver
genesymbol
Noc4l
resolver
uniprot_entry
NOC4L_RAT
resolver
amino_acid_sequence
MERQPASTGSRQELGRLLEAVLSNRGRANAVFDILAVLQSEDPEEIKEGVRTCSRLFGTLLEREELFVGSLPCEDMALAGSQGATYKYKVWMRHRYHSCCNRLEELLTHPSFQVKELALETLMKFVQLEGAKPLEKPQWESHYLFPRTLFRAVVGGLLTPEDDHSLLISQFCEYLEYDDIRYHAMQVATSILARATSRQPEVSLTFWNNAFTLLSAVNLPLQEHELTNFYVKHAQTSSKWKVVHLKEQRKAFQEMWLGFLKHKLPLSLYKKVLVAMHDSILPHLAQPTLMIDFLTSACDVGGAISLLALNGLFILIHKHNLEYPDFYQRLYGLLDPSIFHVKYRARFFHLADLFLSSSHLPAYLVAAFAKRLARLALTAPPEALLMVLPLICNLLRRHPACRVMVHRPQGPELDADPYDPTEKDPARSRALESCLWELQTLQQHYHPEVSRAASVINQALSVPEVSIAPLLELTAYEIFEQDLKKMMPESVPLEFIPAKGLLGRQDDLCTQFFCLS
uniprot
proteins
function
FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit (By similarity). During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Required for the translation of mRNAs related to activation of regulatory and conventional T cells but is not essential for global translation in regulatory T cells (By similarity). Ensures correct nucleolar localization of small ribosomal subunit processome member EMG1 as part of a complex with NOP14 and UTP14A (By similarity). Blocks TLR4 endocytosis, causing inhibition of the TICAM1/TRIF signaling pathway (By similarity). This leads to reduced production of inflammatory cytokines which ameliorates local and systemic inflammation and influences insulin sensitivity (By similarity). Inhibits SIRT1-mediated deacetylation of TP53/p53 (By similarity). Required during early embryogenesis to ensure blastocyst formation (By similarity). {ECO:0000250|UniProtKB:Q8BHY2, ECO:0000250|UniProtKB:Q9BVI4}.
uniprot
proteins
mass_dalton
58862
uniprot
proteins
protein_family
CBF/MAK21 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
516
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q8BHY2}; Multi-pass membrane protein {ECO:0000255}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9BVI4}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9BVI4}. Cytoplasm {ECO:0000250|UniProtKB:Q9BVI4}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q9BVI4}. Early endosome {ECO:0000250|UniProtKB:Q8BHY2}. Note=Localizes to the nucleolus under normal conditions but translocates to the nucleoplasm and cytoplasm under stress conditions. {ECO:0000250|UniProtKB:Q9BVI4}.
uniprot
proteins
transmembrane_region
TRANSMEM 296..316; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 347..367; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 375..395; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins