Ctsl
entrez
25697
canonical
uniprot
P07154
canonical
ensembl
ENSRNOG00000018566
resolver
ensembl
ENSRNOG00055024341
resolver
ensembl
ENSRNOG00060016039
resolver
ensembl
ENSRNOG00065024877
resolver
ensp
ENSRNOP00000093716
resolver
ensp
ENSRNOP00055034068
resolver
ensp
ENSRNOP00060022071
resolver
ensp
ENSRNOP00065034988
resolver
enst
ENSRNOT00000111570
resolver
enst
ENSRNOT00055041830
resolver
enst
ENSRNOT00060027483
resolver
enst
ENSRNOT00065042735
resolver
genesymbol
Ctsl
resolver
genesymbol_syn
Ctsl1
resolver
uniprot
Q9QV07
resolver
uniprot_entry
CATL1_RAT
resolver
uniprot_sec
Q9QV07
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the propeptide produced by autocleavage (By similarity). Long isoform of CD74/Ii chain stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of APCs. IFNG enhances the conversion into the CTSL mature and active form (By similarity). Inhibited by CST6. Inhibited by the glycopeptide antibiotic teicoplanin. Inhibited by amantadine (By similarity). {ECO:0000250|UniProtKB:P06797, ECO:0000250|UniProtKB:P07711}.
uniprot
proteins
amino_acid_sequence
MTPLLLLAVLCLGTALATPKFDQTFNAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTNEEFRQIVNGYRHQKHKKGRLFQEPLMLQIPKTVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPIVN
uniprot
proteins
ec_number
3.4.22.15
uniprot
proteins
function
FUNCTION: Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells. Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (By similarity). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (PubMed:7777858). {ECO:0000250|UniProtKB:P06797, ECO:0000250|UniProtKB:P07711, ECO:0000250|UniProtKB:P25975, ECO:0000269|PubMed:7777858}.
uniprot
proteins
mass_dalton
37660
uniprot
proteins
post_translational_modification
PTM: During export along the endocytic pathway, pro-CTSL undergoes several proteolytic cleavages to generate the CTSL single-chain and two-chain mature forms, composed of a heavy chain linked to a light chain by disulfide bonds (By similarity). Autocleavage; produces the single-chain CTSL after cleavage of the propeptide. The cleavage can be intermolecular (By similarity). {ECO:0000250|UniProtKB:P06797, ECO:0000250|UniProtKB:P07711}.
uniprot
proteins
protein_family
Peptidase C1 family
uniprot
proteins
pubmed
10699763
uniprot
proteins
pubmed
11356678
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1791830
uniprot
proteins
pubmed
2599113
uniprot
proteins
pubmed
26479776
uniprot
proteins
pubmed
3402618
uniprot
proteins
pubmed
3666143
uniprot
proteins
pubmed
7777858
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:7777858}. Apical cell membrane {ECO:0000250|UniProtKB:P06797}; Peripheral membrane protein {ECO:0000250|UniProtKB:P06797}; Extracellular side {ECO:0000250|UniProtKB:P06797}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250|UniProtKB:P25975}. Secreted, extracellular space {ECO:0000250|UniProtKB:P06797}. Secreted {ECO:0000269|PubMed:7777858}. Note=Localizes to the apical membrane of thyroid epithelial cells. Released at extracellular space by activated dendritic cells and macrophages. {ECO:0000250|UniProtKB:P06797}.
uniprot
proteins