FOLR2
entrez
2350
canonical
uniprot
P14207
canonical
ensembl
ENSG00000165457
resolver
ensp
ENSP00000298223
resolver
ensp
ENSP00000538601
resolver
ensp
ENSP00000538602
resolver
ensp
ENSP00000613283
resolver
ensp
ENSP00000613286
resolver
ensp
ENSP00000613287
resolver
enst
ENST00000298223
resolver
enst
ENST00000868542
resolver
enst
ENST00000868543
resolver
enst
ENST00000943224
resolver
enst
ENST00000943228
resolver
genesymbol
FOLR2
resolver
hgnc
HGNC:3793
resolver
uniprot
Q05CA5
resolver
uniprot
Q6GTE8
resolver
uniprot_entry
FOLR2_HUMAN
resolver
uniprot_sec
Q05CA5
resolver
uniprot_sec
Q6GTE8
resolver
amino_acid_sequence
MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRKERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMHVNAGEMLHGTGGLLLSLALMLQLWLLG
uniprot
proteins
function
FUNCTION: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. {ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:4066659}.
uniprot
proteins
mass_dalton
29280
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2605182}.
uniprot
proteins
protein_family
Folate receptor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
20632143
uniprot
proteins
pubmed
23934049
uniprot
proteins
pubmed
2561247
uniprot
proteins
pubmed
2605182
uniprot
proteins
pubmed
4066659
uniprot
proteins
pubmed
7578066
uniprot
proteins
pubmed
8106441
uniprot
proteins
pubmed
8445646
uniprot
proteins
pubmed
9398177
uniprot
proteins
sequence_length
255
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000305}.
uniprot
proteins