E2f7
entrez
52679
canonical
uniprot
Q6S7F2
canonical
ensembl
ENSMUSG00000020185
resolver
ensp
ENSMUSP00000073453
resolver
ensp
ENSMUSP00000133494
resolver
genesymbol
E2f7
resolver
uniprot
B2RWZ8
resolver
uniprot
Q8BRE2
resolver
uniprot
Q8BSQ3
resolver
uniprot
Q8C9R3
resolver
uniprot_entry
E2F7_MOUSE
resolver
uniprot_sec
B2RWZ8
resolver
uniprot_sec
Q8BRE2
resolver
uniprot_sec
Q8BSQ3
resolver
uniprot_sec
Q8C9R3
resolver
amino_acid_sequence
MEVNCLTLKDLISPRQTRLDFAIEDAENAQKENIFVDRSRMTPKTPMKNEPIDLSKQRIFTPDRNPITPVKPVDRQPQVEPWTPTANLKMLISAASPDIRDREKKKELFRPIENKEDAFVNSLQLDVAGDGAVDEYEKQRPSRKQKSLGLLCQKFLARYPSYPLSTEKTTISLDEVAVSLGVERRRIYDIVNVLESLHLVSRVAKNQYGWHGRHSLPKTLRTLQRLGEEQKYEEQMACLQQKELDLMGYRFGERRKDGSPDPRDPHLLDFSEADYPSSSANSRKDKSLRIMSQKFVMLFLVSKTKIVTLDVAAKILIEESQDTPDHSKFKTKVRRLYDIANVLTSLALIKKVHVTEERGRKPAFKWIGPVDFSSIDEELLDVSASILPELKKEAYGQIRVCAKERLVRYGSFNTVHTSEKIQRKVSSEPSSPQGERQGSAYSLEIGSLAAIYRQKVEDNSQEEAFVSNTAVPPASILDPALSMDSEYCVKPLAQPVFSVAQTDLPAFSAQNGPSGQVGVPVPSAASDTENLKPALLAGQPLVYVPSTQLFMLYGSVQEGLSPESRSEEDGGGSDVPADLSVTPSAQKRLCEERDPQEEEDEPAMKRQSQEFEDSPLSLVMPKKPSSSTDLACPVTMGNGSSPPLEDACVKGQLPAAEEVTGKAAPNCYVASECGNPARNPDTEKPSNENEITKDPSLMQYLYVQSPAGLNGFNMVLPGTQTPHTVAPSPAQLPSFGVPCMFLQSPGLGPFPVLYSPAIPGPISSAPGTHPNPGPMNFGLSTLASASHLLISPAAMVNPKPSTLPCTDPQLRCQPSLNLNPVMPGSHGVIHPESPCYVRHPVSMVKAEQSPAPATPKSIQRRHRETFFKTPGSLGDPVFRRKERNQSRNTSSAQRRLEISSSGPD
uniprot
proteins
function
FUNCTION: Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation. {ECO:0000269|PubMed:12893818, ECO:0000269|PubMed:18194653, ECO:0000269|PubMed:22180533, ECO:0000269|PubMed:22516201, ECO:0000269|PubMed:22802529, ECO:0000269|PubMed:22903062, ECO:0000269|PubMed:23064264, ECO:0000269|PubMed:23064266}.
uniprot
proteins
mass_dalton
99535
uniprot
proteins
protein_family
E2F/DP family
uniprot
proteins
pubmed
12893818
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18194653
uniprot
proteins
pubmed
22180533
uniprot
proteins
pubmed
22516201
uniprot
proteins
pubmed
22802529
uniprot
proteins
pubmed
22903062
uniprot
proteins
pubmed
23064264
uniprot
proteins
pubmed
23064266
uniprot
proteins
sequence_length
904
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12893818}.
uniprot
proteins