POMC
entrez
5443
canonical
uniprot
P01189
canonical
ensembl
ENSG00000115138
resolver
ensp
ENSP00000264708
resolver
ensp
ENSP00000370171
resolver
ensp
ENSP00000379170
resolver
ensp
ENSP00000384092
resolver
ensp
ENSP00000387993
resolver
ensp
ENSP00000612398
resolver
enst
ENST00000264708
resolver
enst
ENST00000380794
resolver
enst
ENST00000395826
resolver
enst
ENST00000405623
resolver
enst
ENST00000942339
resolver
genesymbol
POMC
resolver
hgnc
HGNC:9201
resolver
uniprot
P78442
resolver
uniprot
Q53T23
resolver
uniprot
Q9UD39
resolver
uniprot
Q9UD40
resolver
uniprot_entry
COLI_HUMAN
resolver
uniprot_sec
P78442
resolver
uniprot_sec
Q53T23
resolver
uniprot_sec
Q9UD39
resolver
uniprot_sec
Q9UD40
resolver
amino_acid_sequence
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGGPEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKRELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE
uniprot
proteins
disease_involvement
DISEASE: Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269|PubMed:12165561}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.; DISEASE: Obesity, early-onset, with adrenal insufficiency and red hair (OBAIRH) [MIM:609734]: An autosomal recessive disorder characterized by early-onset obesity due to severe hyperphagia, pigmentary abnormalities, mainly pale skin and red hair, and secondary hypocortisolism. {ECO:0000269|PubMed:9620771}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Precursor protein of pituitary hormones that are involved in diverse physiological processes, including the regulation of energy balance, stress response, immune function and skin pigmentation. {ECO:0000269|PubMed:10403794, ECO:0000269|PubMed:8392067, ECO:0000269|PubMed:8396929, ECO:0000269|PubMed:8463333, ECO:0000269|PubMed:8636348, ECO:0000269|PubMed:9620771}.; FUNCTION: [Corticotropin]: Functions as a ligand for the melanocortin receptors MC1R, MC2R, MC3R and MC5R (PubMed:8396929, PubMed:8463333, PubMed:8636348). Activation of MC1R increases melanogenesis in melanocytes found in the skin and hair (PubMed:9620771). Binding to MC2R stimulates the adrenal glands to secrete cortisol (PubMed:8636348). Contributes to the regulation of energy homeostasis through activation of MC3R (Probable). Involved in the regulation exocrine gland function through MC5R activation (By similarity). {ECO:0000250|UniProtKB:P01193, ECO:0000269|PubMed:8396929, ECO:0000269|PubMed:8463333, ECO:0000269|PubMed:8636348, ECO:0000269|PubMed:9620771, ECO:0000305|PubMed:8463333}.; FUNCTION: [Melanocyte-stimulating hormone alpha]: Serves as a ligand for the melanocortin receptors MC1R, MC3R, MC4R and MC5R (PubMed:8392067, PubMed:8396929, PubMed:8463333). Activation of MC1R promotes melanogenesis in melanocytes of the skin and hair (PubMed:10403794, PubMed:9620771). Contributes to the regulation of energy homeostasis through activation of MC3R (Probable). Through MC4R activation, functions as an anorexigenic peptide (PubMed:8392067). Promotes immunosuppression and involved in the regulation exocrine gland function through MC5R activation (By similarity). {ECO:0000250|UniProtKB:P01193, ECO:0000269|PubMed:10403794, ECO:0000269|PubMed:8392067, ECO:0000269|PubMed:8396929, ECO:0000269|PubMed:8463333, ECO:0000269|PubMed:9620771, ECO:0000305|PubMed:8463333}.; FUNCTION: [Melanocyte-stimulating hormone beta]: Functions as a ligand for the melanocortin receptors MC1R, MC3R, MC4R and MC5R (PubMed:8396929, PubMed:8463333). Activation of MC1R increases melanogenesis in melanocytes found in the skin and hair (Probable). Contributes to the regulation of energy homeostasis through activation of MC3R (Probable). Through MC4R activation, functions as an anorexigenic peptide (PubMed:8392067). Involved in the regulation exocrine gland function through MC5R activation (By similarity). {ECO:0000250|UniProtKB:P01193, ECO:0000269|PubMed:8392067, ECO:0000269|PubMed:8396929, ECO:0000269|PubMed:8463333, ECO:0000305|PubMed:8463333}.; FUNCTION: [Melanotropin gamma]: Functions as a ligand for the melanocortin receptors MC1R, MC3R, MC4R and MC5R (PubMed:8396929, PubMed:8463333). Activation of MC1R increases melanogenesis in melanocytes found in the skin and hair (Probable). Contributes to the regulation of energy homeostasis through activation of MC3R (Probable). Binds to MC4R with low potency (PubMed:8392067). Involved in the regulation exocrine gland function through MC5R activation (By similarity). {ECO:0000250|UniProtKB:P01193, ECO:0000269|PubMed:8392067, ECO:0000269|PubMed:8396929, ECO:0000269|PubMed:8463333, ECO:0000305|PubMed:8463333}.; FUNCTION: [Beta-endorphin]: Endogenous orexigenic opiate.; FUNCTION: [Met-enkephalin]: Endogenous opiate.
uniprot
proteins
mass_dalton
29424
uniprot
proteins
post_translational_modification
PTM: Specific enzymatic cleavages at paired basic residues yield the different active peptides. {ECO:0000269|PubMed:2839146}.; PTM: O-glycosylated; reducing sugar is probably N-acetylgalactosamine.
uniprot
proteins
protein_family
POMC family
uniprot
proteins
pubmed
10193875
uniprot
proteins
pubmed
10403794
uniprot
proteins
pubmed
11244459
uniprot
proteins
pubmed
12165561
uniprot
proteins
pubmed
1264228
uniprot
proteins
pubmed
14463577
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16046320
uniprot
proteins
pubmed
16807684
uniprot
proteins
pubmed
195688
uniprot
proteins
pubmed
2424570
uniprot
proteins
pubmed
2839146
uniprot
proteins
pubmed
3606677
uniprot
proteins
pubmed
4334191
uniprot
proteins
pubmed
4338630
uniprot
proteins
pubmed
4347148
uniprot
proteins
pubmed
4352834
uniprot
proteins
pubmed
6254047
uniprot
proteins
pubmed
6267033
uniprot
proteins
pubmed
6272808
uniprot
proteins
pubmed
6274691
uniprot
proteins
pubmed
6299668
uniprot
proteins
pubmed
6314261
uniprot
proteins
pubmed
6945581
uniprot
proteins
pubmed
7828531
uniprot
proteins
pubmed
8392067
uniprot
proteins
pubmed
8396929
uniprot
proteins
pubmed
8463333
uniprot
proteins
pubmed
8636348
uniprot
proteins
pubmed
9620771
uniprot
proteins
pubmed
9768693
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}. Note=Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms. {ECO:0000250|UniProtKB:P01193}.
uniprot
proteins