SLC12A7
entrez
10723
canonical
uniprot
Q9Y666
canonical
ensembl
ENSG00000113504
resolver
ensp
ENSP00000264930
resolver
ensp
ENSP00000489285
resolver
ensp
ENSP00000521081
resolver
ensp
ENSP00000615222
resolver
genesymbol
SLC12A7
resolver
genesymbol_syn
KCC4
resolver
hgnc
HGNC:10915
resolver
uniprot
A6NDS8
resolver
uniprot
Q4G0F3
resolver
uniprot
Q96I81
resolver
uniprot
Q9H7I3
resolver
uniprot
Q9H7I7
resolver
uniprot
Q9UFW2
resolver
uniprot_entry
S12A7_HUMAN
resolver
uniprot_sec
A6NDS8
resolver
uniprot_sec
Q4G0F3
resolver
uniprot_sec
Q96I81
resolver
uniprot_sec
Q9H7I3
resolver
uniprot_sec
Q9H7I7
resolver
uniprot_sec
Q9UFW2
resolver
activity_regulation
ACTIVITY REGULATION: Activated by N-ethylmaleimide (NEM). Inhibited by furosemide, DIDS and bumetanide. The inhibition is much stronger in the presence of 50 mM K(+) in the uptake medium. Inhibited by DIOA. Inhibited by WNK3. {ECO:0000269|PubMed:21613606}.
uniprot
proteins
amino_acid_sequence
MPTNFTVVPVEAHADGGGDETAERTEAPGTPEGPEPERPSPGDGNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS
uniprot
proteins
function
FUNCTION: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250, ECO:0000269|PubMed:10913127}.
uniprot
proteins
mass_dalton
119106
uniprot
proteins
protein_family
K/Cl co-transporter subfamily
uniprot
proteins
protein_family
SLC12A transporter family
uniprot
proteins
pubmed
10347194
uniprot
proteins
pubmed
10913127
uniprot
proteins
pubmed
11214971
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21613606
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
33310850
uniprot
proteins
sequence_length
1083
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10913127}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 120..142; /note="Discontinuously helical; Name=1"; /evidence="ECO:0000269|PubMed:33310850, ECO:0007744|PDB:7D99"; TRANSMEM 150..172; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:33310850, ECO:0007744|PDB:7D99"; TRANSMEM 197..225; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:33310850, ECO:0007744|PDB:7D99"; TRANSMEM 250..270; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:33310850, ECO:0007744|PDB:7D99"; TRANSMEM 272..300; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:33310850, ECO:0007744|PDB:7D99"; TRANSMEM 420..440; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:33310850, ECO:0007744|PDB:7D99"; TRANSMEM 451..473; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:33310850, ECO:0007744|PDB:7D99"; TRANSMEM 505..531; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:33310850, ECO:0007744|PDB:7D99"; TRANSMEM 555..571; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:33310850, ECO:0007744|PDB:7D99"; TRANSMEM 574..598; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:33310850, ECO:0007744|PDB:7D99"; TRANSMEM 613..632; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:33310850, ECO:0007744|PDB:7D99"; TRANSMEM 636..651; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:33310850, ECO:0007744|PDB:7D99
uniprot
proteins