LCN2
entrez
3934
canonical
uniprot
P80188
canonical
ensembl
ENSG00000148346
resolver
ensp
ENSP00000277480
resolver
ensp
ENSP00000362108
resolver
genesymbol
LCN2
resolver
genesymbol_syn
HNL
resolver
genesymbol_syn
NGAL
resolver
hgnc
HGNC:6526
resolver
uniprot
A6NII8
resolver
uniprot
B4DWV4
resolver
uniprot
B7ZAA2
resolver
uniprot
P30150
resolver
uniprot
Q5SYV9
resolver
uniprot
Q5SYW0
resolver
uniprot
Q6FGL5
resolver
uniprot
Q92683
resolver
uniprot_entry
NGAL_HUMAN
resolver
uniprot_sec
A6NII8
resolver
uniprot_sec
B4DWV4
resolver
uniprot_sec
B7ZAA2
resolver
uniprot_sec
P30150
resolver
uniprot_sec
Q5SYV9
resolver
uniprot_sec
Q5SYW0
resolver
uniprot_sec
Q6FGL5
resolver
uniprot_sec
Q92683
resolver
amino_acid_sequence
MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNAILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFVPGCQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKITLYGRTKELTSELKENFIRFSKSLGLPENHIVFPVPIDQCIDG
uniprot
proteins
function
FUNCTION: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:20581821, PubMed:27780864). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:27780864). Can also bind siderophores from M.tuberculosis (PubMed:15642259, PubMed:21978368). {ECO:0000250|UniProtKB:P11672, ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:15642259, ECO:0000269|PubMed:20581821, ECO:0000269|PubMed:21978368, ECO:0000269|PubMed:27780864}.
uniprot
proteins
mass_dalton
22588
uniprot
proteins
mutagenesis
MUTAGEN 145; /note="K->A: Strongly reduced affinity for catecholate-type ferric siderophores; when associated with A-154."; /evidence="ECO:0000269|PubMed:20581821"; MUTAGEN 154; /note="K->A: Strongly reduced affinity for catecholate-type ferric siderophores; when associated with A-145."; /evidence="ECO:0000269|PubMed:20581821
uniprot
proteins
protein_family
Calycin superfamily
uniprot
proteins
protein_family
Lipocalin family
uniprot
proteins
pubmed
10339412
uniprot
proteins
pubmed
10684642
uniprot
proteins
pubmed
12453412
uniprot
proteins
pubmed
12453413
uniprot
proteins
pubmed
1281792
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15084671
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15642259
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16740002
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19229297
uniprot
proteins
pubmed
20581821
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21978368
uniprot
proteins
pubmed
27780864
uniprot
proteins
pubmed
30418175
uniprot
proteins
pubmed
7683678
uniprot
proteins
pubmed
7835423
uniprot
proteins
pubmed
8060329
uniprot
proteins
pubmed
8298140
uniprot
proteins
pubmed
9339356
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:27780864, ECO:0000269|PubMed:7683678}. Cytoplasmic granule lumen {ECO:0000269|PubMed:8298140}. Cytoplasmic vesicle lumen {ECO:0000269|PubMed:12453413}. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized (By similarity). Releases the bound iron in the acidic lumen of cytoplasmic vesicles (PubMed:12453413, PubMed:20581821). {ECO:0000250|UniProtKB:P11672, ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:20581821}.
uniprot
proteins