Mrap2
entrez
244958
canonical
uniprot
D3Z1Q2
canonical
ensembl
ENSMUSG00000042761
resolver
ensp
ENSMUSP00000046271
resolver
ensp
ENSMUSP00000108774
resolver
ensp
ENSMUSP00000135904
resolver
ensp
ENSMUSP00000254791
resolver
ensp
ENSMUSP00000254792
resolver
ensp
ENSMUSP00000254794
resolver
ensp
ENSMUSP00000254795
resolver
ensp
ENSMUSP00000254799
resolver
ensp
ENSMUSP00000254800
resolver
enst
ENSMUST00000049457
resolver
enst
ENSMUST00000113149
resolver
enst
ENSMUST00000179313
resolver
genesymbol
Mrap2
resolver
uniprot
D3YVA7
resolver
uniprot
D3YZ75
resolver
uniprot
D3Z746
resolver
uniprot_entry
MRAP2_MOUSE
resolver
uniprot_sec
D3YVA7
resolver
uniprot_sec
D3YZ75
resolver
uniprot_sec
D3Z746
resolver
amino_acid_sequence
MEMSAQRLASNRTSPQSPSNSDYTWEYEYYEIGPVSFEGLKAHKYSIVIGFWVGLAVFVIFMFFVLTLLTKTGAPHQDNAESSERRFRMNSFVSDFGKPLESDKVFSRQGNEESRSLFHCYINEVEHLDRVKVCHQTTAIDSDVHLQEASRSSGRPEEELARFMKFDIPNFVNTEQSSFGEDDLLISEAPVLLENKPVSQTSRIDLD
uniprot
proteins
function
FUNCTION: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo. {ECO:0000269|PubMed:20371771, ECO:0000269|PubMed:23869016}.
uniprot
proteins
mass_dalton
23678
uniprot
proteins
protein_family
MRAP family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20371771
uniprot
proteins
pubmed
23869016
uniprot
proteins
sequence_length
207
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins