H1-0
entrez
3005
canonical
uniprot
P07305
canonical
ensembl
ENSG00000189060
resolver
ensp
ENSP00000344504
resolver
genesymbol
H1-0
resolver
genesymbol_syn
H1F0
resolver
genesymbol_syn
H1FV
resolver
hgnc
HGNC:4714
resolver
uniprot
B2R6I0
resolver
uniprot
B4DRD6
resolver
uniprot
Q6FG88
resolver
uniprot
Q8N6R3
resolver
uniprot_entry
H10_HUMAN
resolver
uniprot_sec
B2R6I0
resolver
uniprot_sec
B4DRD6
resolver
uniprot_sec
Q6FG88
resolver
uniprot_sec
Q8N6R3
resolver
amino_acid_sequence
MTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKSDEPKKSVAFKKTKKEIKKVATPKKASKPKKAASKAPTKKPKATPVKKAKKKLAATPKKAKKPKTVKAKPVKASKPKKAKPVKPKAKSSAKRAGKKK
uniprot
proteins
function
FUNCTION: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:33238161). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed:33238161). The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division (PubMed:7374750). {ECO:0000269|PubMed:33238161, ECO:0000269|PubMed:7374750}.
uniprot
proteins
mass_dalton
20863
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-17 in RNA edited version. {ECO:0000269|PubMed:18993075}.; PTM: ADP-ribosylated on Ser-104 in response to DNA damage. {ECO:0000269|PubMed:27723750}.
uniprot
proteins
protein_family
Histone H1/H5 family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18993075
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25645921
uniprot
proteins
pubmed
27723750
uniprot
proteins
pubmed
3084796
uniprot
proteins
pubmed
33238161
uniprot
proteins
pubmed
38530350
uniprot
proteins
pubmed
7374750
uniprot
proteins
pubmed
9582379
uniprot
proteins
sequence_length
194
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837, ECO:0000269|PubMed:18993075}. Nucleus, nucleolus {ECO:0000269|PubMed:25645921}. Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837, ECO:0000269|PubMed:18993075, ECO:0000269|PubMed:25645921, ECO:0000269|PubMed:38530350}. Note=Enriched at nucleolus-associated DNA repeats and chromatin domains (PubMed:25645921). During mitosis, it appears in the vicinity of condensed chromosomes (PubMed:18993075). The RNA edited version has been localized to nuclear speckles (PubMed:18993075). Comparted to other H1 histones, shows a less pronounced peripheral nuclear localization (PubMed:38530350). {ECO:0000269|PubMed:18993075, ECO:0000269|PubMed:25645921, ECO:0000269|PubMed:38530350}.
uniprot
proteins