Adap2
entrez
56826
canonical
uniprot
Q9JK15
canonical
genesymbol
Adap2
resolver
genesymbol_syn
Centa2
resolver
uniprot_entry
ADAP2_RAT
resolver
amino_acid_sequence
MGDRERNKKRLLELLQAAGTGNGHCADCGAADPDWASYKLGVFICLHCSGVHRNFPDISKVKSVRLDFWDDSMVEFMTHNGNLSVKAKFEARVPTFYYVPQASDCLVLKEQWIRAKYERQEFMAEKAVSPPGDREGFLWKRGRDNSQFLRRRFVLLSREGLLKYYTKEEGKTPKAIINIKDLNATFQTEKIGHPHGLQITYRKEGQTRNLFVYHDSGKEIVDWFNALRAARLQYLKLAFPDLPESELVPLITRNYLKQGFMEKTGPKHREPFKKRWFALDPQERRLLYYKNPLDAFEQGQVFLGSNEQGYEVWEGLPQGIRGNRWKVGLTVITPERKFVFTCPTEKEQREWLESLRGVLSSPLSPLHLLTTSAKSG
uniprot
proteins
function
FUNCTION: GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Binding of phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4-bisphosphate occurs at a much lower affinity. Possesses a stoichiometry of two binding sites for InsP4 with identical affinity (By similarity). {ECO:0000250, ECO:0000305}.
uniprot
proteins
mass_dalton
43524
uniprot
proteins
mutagenesis
MUTAGEN 151; /note="R->C: Almost complete loss of InsP4 binding."; /evidence="ECO:0000269|PubMed:12018390"; MUTAGEN 275; /note="R->C: No loss of InsP4 binding. Almost complete loss of InsP4 binding; when associated with C-151."; /evidence="ECO:0000269|PubMed:12018390
uniprot
proteins
pubmed
12018390
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Constitutively associated with the plasma membrane. Excluded from the nucleus (By similarity). {ECO:0000250}.
uniprot
proteins