RNF144A
entrez
9781
canonical
uniprot
P50876
canonical
ensembl
ENSG00000151692
resolver
ensp
ENSP00000321330
resolver
ensp
ENSP00000411616
resolver
ensp
ENSP00000572645
resolver
ensp
ENSP00000572646
resolver
ensp
ENSP00000572647
resolver
ensp
ENSP00000572648
resolver
ensp
ENSP00000572649
resolver
ensp
ENSP00000572650
resolver
ensp
ENSP00000612587
resolver
ensp
ENSP00000612588
resolver
enst
ENST00000320892
resolver
enst
ENST00000902586
resolver
enst
ENST00000902587
resolver
enst
ENST00000902588
resolver
enst
ENST00000902589
resolver
enst
ENST00000902590
resolver
enst
ENST00000902591
resolver
enst
ENST00000942528
resolver
enst
ENST00000942529
resolver
genesymbol
RNF144A
resolver
genesymbol_syn
KIAA0161
resolver
genesymbol_syn
RNF144
resolver
genesymbol_syn
UBCE7IP4
resolver
hgnc
HGNC:20457
resolver
uniprot
D6W4Y6
resolver
uniprot
Q585H5
resolver
uniprot_entry
R144A_HUMAN
resolver
uniprot_sec
D6W4Y6
resolver
uniprot_sec
Q585H5
resolver
amino_acid_sequence
MTTTRYRPTWDLALDPLVSCKLCLGEYPVEQMTTIAQCQCIFCTLCLKQYVELLIKEGLETAISCPDAACPKQGHLQENEIECMVAAEIMQRYKKLQFEREVLFDPCRTWCPASTCQAVCQLQDVGLQTPQPVQCKACRMEFCSTCKASWHPGQGCPETMPITFLPGETSAAFKMEEDDAPIKRCPKCKVYIERDEGCAQMMCKNCKHAFCWYCLESLDDDFLLIHYDKGPCRNKLGHSRASVIWHRTQVVGIFAGFGLLLLVASPFLLLATPFVLCCKCKCSKGDDDPLPT
uniprot
proteins
ec_number
2.3.2.31
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:26216882). Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC during DNA damage (PubMed:24979766). Positively regulates DNA virus or exogenous cytosolic DNA-triggered innate immune response by mediating STING1 ubiquitination and increasing its 'Lys-6'-linked ubiquitination and translocation from the endoplasmic reticulum to the Golgi leading to downstream signaling pathways (PubMed:37955227). Plays a positive role in EGF-dependent cell proliferation by prolonging EGF/EGFR signaling during EGF stimulation through EGFR ubiquitination (PubMed:30171075). Increases ERK activity independently of EGFR signaling by promoting polyubiquitination and subsequent degradation of VRK3 in the cytosol (PubMed:33067254). {ECO:0000250, ECO:0000269|PubMed:24979766, ECO:0000269|PubMed:26216882, ECO:0000269|PubMed:30171075, ECO:0000269|PubMed:33067254, ECO:0000269|PubMed:37955227}.
uniprot
proteins
mass_dalton
32890
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="C->A: Complete loss of ubiquitin ligase activity and auto-ubiquitination; when associated with A-23."; /evidence="ECO:0000269|PubMed:26216882, ECO:0000269|PubMed:30171075, ECO:0000269|PubMed:37955227"; MUTAGEN 23; /note="C->A: Complete loss of ubiquitin ligase activity and auto-ubiquitination; when associated with A-20."; /evidence="ECO:0000269|PubMed:26216882, ECO:0000269|PubMed:30171075, ECO:0000269|PubMed:37955227"; MUTAGEN 252; /note="G->D: Preserves membrane localization but is defective ubiquitin ligase activity."; /evidence="ECO:0000269|PubMed:37955227"; MUTAGEN 252; /note="G->L: Preserves membrane localization but is defective in self-association and ubiquitin ligase activity; when associated with L-256."; /evidence="ECO:0000269|PubMed:37955227"; MUTAGEN 256; /note="G->L: Preserves membrane localization but is defective in self-association and ubiquitin ligase activity; when associated with L-252."; /evidence="ECO:0000269|PubMed:37955227
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000269|PubMed:24979766, ECO:0000269|PubMed:26216882}.
uniprot
proteins
protein_family
RBR family
uniprot
proteins
protein_family
RNF144 subfamily
uniprot
proteins
pubmed
10431818
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
24979766
uniprot
proteins
pubmed
26216882
uniprot
proteins
pubmed
30171075
uniprot
proteins
pubmed
33067254
uniprot
proteins
pubmed
37955227
uniprot
proteins
pubmed
8724849
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24979766, ECO:0000269|PubMed:30171075}; Single-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:24979766, ECO:0000269|PubMed:37955227}. Endosome membrane {ECO:0000269|PubMed:30171075}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:37955227}.
uniprot
proteins
transmembrane_region
TRANSMEM 250..270; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins