IL1RAP
entrez
3556
canonical
uniprot
Q9NPH3
canonical
ensembl
ENSG00000196083
resolver
ensp
ENSP00000072516
resolver
ensp
ENSP00000314807
resolver
ensp
ENSP00000387371
resolver
ensp
ENSP00000390541
resolver
ensp
ENSP00000401132
resolver
ensp
ENSP00000409352
resolver
ensp
ENSP00000593046
resolver
ensp
ENSP00000640399
resolver
ensp
ENSP00000684254
resolver
genesymbol
IL1RAP
resolver
genesymbol_syn
C3orf13
resolver
genesymbol_syn
IL1R3
resolver
hgnc
HGNC:5995
resolver
uniprot
A8K6K4
resolver
uniprot
B1NLD0
resolver
uniprot
D3DNW0
resolver
uniprot
O14915
resolver
uniprot
Q86WJ7
resolver
uniprot_entry
A8K6K4_HUMAN
resolver
uniprot_entry
IL1AP_HUMAN
resolver
uniprot_sec
B1NLD0
resolver
uniprot_sec
D3DNW0
resolver
uniprot_sec
O14915
resolver
uniprot_sec
Q86WJ7
resolver
amino_acid_sequence
MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKSPRRSSSDEQGLSYSSLKNV
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:10799889, ECO:0000269|PubMed:9371760, ECO:0000305|PubMed:10653850, ECO:0000305|PubMed:19836339}.; FUNCTION: [Isoform 2]: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity). {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:12530978}.; FUNCTION: [Isoform 4]: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity). {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:19481478}.
uniprot
proteins
mass_dalton
65418
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
10653850
uniprot
proteins
pubmed
10799889
uniprot
proteins
pubmed
12530978
uniprot
proteins
pubmed
12659850
uniprot
proteins
pubmed
12781872
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17949817
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19481478
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19836339
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20802483
uniprot
proteins
pubmed
20805474
uniprot
proteins
pubmed
22723552
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23479569
uniprot
proteins
pubmed
25595648
uniprot
proteins
pubmed
9371760
uniprot
proteins
pubmed
9479509
uniprot
proteins
pubmed
9862719
uniprot
proteins
sequence_length
570
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 368..388; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins