Egr1
entrez
13653
canonical
uniprot
P08046
canonical
ensembl
ENSMUSG00000038418
resolver
ensp
ENSMUSP00000069616
resolver
enst
ENSMUST00000064795
resolver
genesymbol
Egr1
resolver
genesymbol_syn
Egr-1
resolver
genesymbol_syn
Krox-24
resolver
uniprot
Q544D6
resolver
uniprot
Q61777
resolver
uniprot
Q8CAT6
resolver
uniprot_entry
EGR1_MOUSE
resolver
uniprot_entry
Q544D6_MOUSE
resolver
uniprot_entry
Q8CAT6_MOUSE
resolver
uniprot_sec
Q61777
resolver
amino_acid_sequence
MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGTPEGSGGNSSSSTSSGGGGGGGSNSGSSAFNPQGEPSEQPYEHLTTESFSDIALNNEKAMVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPTSSSSAPSPAASSSSSASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPATKGGFQVPMIPDYLFPQQQGDLSLGTPDQKPFQGLENRTQQPSLTPLSTIKAFATQSGSQDLKALNTTYQSQLIKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASPAASSLSSYPSPVATSYPSPATTSFPSPVPTSYSSPGSSTYPSPAHSGFPSPSVATTFASVPPAFPTQVSSFPSAGVSSSFSTSTGLSDMTATFSPRTIEIC
uniprot
proteins
function
FUNCTION: Transcriptional regulator (PubMed:15958557, PubMed:8336701, PubMed:8703054). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (PubMed:15958557, PubMed:2028256, PubMed:8703054, PubMed:8939742). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia (PubMed:11100120, PubMed:15958557). Plays a role in the regulation of cell survival, proliferation and cell death (PubMed:15265859, PubMed:15958557). Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation (PubMed:15958557). Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy (PubMed:15265859). Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia (PubMed:11100120). Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (PubMed:8703054). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription (PubMed:26471974). Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (PubMed:29138967). {ECO:0000250|UniProtKB:P18146, ECO:0000269|PubMed:11100120, ECO:0000269|PubMed:15265859, ECO:0000269|PubMed:15958557, ECO:0000269|PubMed:2028256, ECO:0000269|PubMed:26471974, ECO:0000269|PubMed:29138967, ECO:0000269|PubMed:8336701, ECO:0000269|PubMed:8703054, ECO:0000269|PubMed:8939742, ECO:0000305}.
uniprot
proteins
mass_dalton
56590
uniprot
proteins
protein_family
EGR C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
11100120
uniprot
proteins
pubmed
15265859
uniprot
proteins
pubmed
15958557
uniprot
proteins
pubmed
1740423
uniprot
proteins
pubmed
2028256
uniprot
proteins
pubmed
2511075
uniprot
proteins
pubmed
26471974
uniprot
proteins
pubmed
29138967
uniprot
proteins
pubmed
3127059
uniprot
proteins
pubmed
3133658
uniprot
proteins
pubmed
3141919
uniprot
proteins
pubmed
8336701
uniprot
proteins
pubmed
8703054
uniprot
proteins
pubmed
8939742
uniprot
proteins
sequence_length
533
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11100120, ECO:0000269|PubMed:15958557, ECO:0000269|PubMed:8336701}. Cytoplasm {ECO:0000250|UniProtKB:P18146}.
uniprot
proteins