BCAR1
entrez
9564
canonical
uniprot
P56945
canonical
ensembl
ENSG00000050820
resolver
ensp
ENSP00000162330
resolver
ensp
ENSP00000377072
resolver
ensp
ENSP00000377074
resolver
ensp
ENSP00000391669
resolver
ensp
ENSP00000392708
resolver
ensp
ENSP00000440370
resolver
ensp
ENSP00000440415
resolver
ensp
ENSP00000443841
resolver
ensp
ENSP00000598407
resolver
genesymbol
BCAR1
resolver
genesymbol_syn
CAS
resolver
genesymbol_syn
CASS1
resolver
genesymbol_syn
CRKAS
resolver
hgnc
HGNC:971
resolver
uniprot
B3KWD7
resolver
uniprot
B3KWE2
resolver
uniprot
B4DEV4
resolver
uniprot
B4DGB5
resolver
uniprot
B4DIW5
resolver
uniprot
B7Z7X7
resolver
uniprot
E9PCL5
resolver
uniprot
E9PCV2
resolver
uniprot
F5GXA2
resolver
uniprot
F5GXV6
resolver
uniprot
F5H7Z0
resolver
uniprot
F8WA69
resolver
uniprot
Q6QEF7
resolver
uniprot_entry
B3KWE2_HUMAN
resolver
uniprot_entry
BCAR1_HUMAN
resolver
uniprot_sec
B3KWD7
resolver
uniprot_sec
B4DEV4
resolver
uniprot_sec
B4DGB5
resolver
uniprot_sec
B4DIW5
resolver
uniprot_sec
B7Z7X7
resolver
uniprot_sec
E9PCL5
resolver
uniprot_sec
E9PCV2
resolver
uniprot_sec
F5GXA2
resolver
uniprot_sec
F5GXV6
resolver
uniprot_sec
F5H7Z0
resolver
uniprot_sec
F8WA69
resolver
uniprot_sec
Q6QEF7
resolver
amino_acid_sequence
MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGYVYEAAQPEQDEYDIPRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAPPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPKFTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA
uniprot
proteins
function
FUNCTION: Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}.
uniprot
proteins
mass_dalton
93372
uniprot
proteins
mutagenesis
MUTAGEN 787; /note="L->E: Weakens interaction with SH2D3C."; /evidence="ECO:0000269|PubMed:22081014"; MUTAGEN 794; /note="F->R: Weakens interaction with SH2D3C."; /evidence="ECO:0000269|PubMed:22081014"; MUTAGEN 797; /note="D->R: Weakens interaction with SH2D3C."; /evidence="ECO:0000269|PubMed:22081014
uniprot
proteins
post_translational_modification
PTM: PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular matrix. {ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19454314, ECO:0000269|PubMed:22710723}.; PTM: Dephosphorylated by PTPN14 at Tyr-128.; PTM: Phosphorylated by SRC kinase in a EDN1- and PTK2B-mediated manner; phosphorylation strengthens its interaction with BCAR3 as part of the PTK2B/BCAR1/BCAR3/RAP1 signaling pathway. {ECO:0000269|PubMed:19086031}.
uniprot
proteins
protein_family
CAS family
uniprot
proteins
pubmed
10502414
uniprot
proteins
pubmed
10587647
uniprot
proteins
pubmed
10639512
uniprot
proteins
pubmed
11158326
uniprot
proteins
pubmed
12432078
uniprot
proteins
pubmed
12832404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
15784259
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17038317
uniprot
proteins
pubmed
17174122
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19086031
uniprot
proteins
pubmed
19147981
uniprot
proteins
pubmed
19454314
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20534451
uniprot
proteins
pubmed
20798394
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22081014
uniprot
proteins
pubmed
22710723
uniprot
proteins
pubmed
22801373
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9020138
uniprot
proteins
sequence_length
870
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:12832404}. Cytoplasm {ECO:0000269|PubMed:12832404}. Cell projection, axon {ECO:0000250|UniProtKB:Q61140}. Note=Unphosphorylated form localizes in the cytoplasm (By similarity). Localizes to focal adhesion sites following integrin engagement (By similarity). {ECO:0000250|UniProtKB:Q61140}.
uniprot
proteins