CHRNB4
entrez
1143
canonical
uniprot
P30926
canonical
ensembl
ENSG00000117971
resolver
ensp
ENSP00000261751
resolver
ensp
ENSP00000416386
resolver
genesymbol
CHRNB4
resolver
hgnc
HGNC:1964
resolver
uniprot
A4FTX5
resolver
uniprot
E9PHE8
resolver
uniprot
Q16607
resolver
uniprot
Q4VBA5
resolver
uniprot
Q8WXC8
resolver
uniprot
Q9BQR4
resolver
uniprot_entry
ACHB4_HUMAN
resolver
uniprot_sec
A4FTX5
resolver
uniprot_sec
E9PHE8
resolver
uniprot_sec
Q16607
resolver
uniprot_sec
Q4VBA5
resolver
uniprot_sec
Q8WXC8
resolver
uniprot_sec
Q9BQR4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by a myriad of ligands such as acetylcholine, cytisine, nicotine, choline and epibatidine (PubMed:11118490, PubMed:20881005, PubMed:31488329, PubMed:8906617). The heteropentamer CHRNA3:CHRNB4 activity is blocked by the alpha-conotoxin ImI and AuIB (PubMed:15609996). {ECO:0000269|PubMed:11118490, ECO:0000269|PubMed:15609996, ECO:0000269|PubMed:20881005, ECO:0000269|PubMed:31488329, ECO:0000269|PubMed:8906617}.
uniprot
proteins
amino_acid_sequence
MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPLFQTHAASEGPYAAQRD
uniprot
proteins
function
FUNCTION: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:20881005, PubMed:31488329, PubMed:8663494, PubMed:8906617, PubMed:9203638). CHRNB4 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3 and CHRNA4, as well as CHRNA5 and CHRNB3 as accesory subunits (PubMed:11118490, PubMed:20881005, PubMed:8663494). CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (PubMed:31488329). CHRNA3:CHRNB4 or CHRNA3:CHRNA5:CHRNB4 play also an important role in the habenulo-interpeduncular tract, modulating the mesolimbic dopamine system and affecting reward circuits and addiction (By similarity). Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity). {ECO:0000250|UniProtKB:P12392, ECO:0000250|UniProtKB:Q8R493, ECO:0000269|PubMed:11118490, ECO:0000269|PubMed:20881005, ECO:0000269|PubMed:31488329, ECO:0000269|PubMed:8663494, ECO:0000269|PubMed:8906617, ECO:0000269|PubMed:9203638}.
uniprot
proteins
mass_dalton
56380
uniprot
proteins
mutagenesis
MUTAGEN 272; /note="L->T: Increases potency of agonists."; /evidence="ECO:0000269|PubMed:11118490
uniprot
proteins
protein_family
Acetylcholine receptor (TC 1.A.9.1) subfamily
uniprot
proteins
protein_family
Beta-4/CHRNB4 sub-subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
11118490
uniprot
proteins
pubmed
11450844
uniprot
proteins
pubmed
11742001
uniprot
proteins
pubmed
1330682
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15609996
uniprot
proteins
pubmed
16120769
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
20881005
uniprot
proteins
pubmed
27344019
uniprot
proteins
pubmed
31488329
uniprot
proteins
pubmed
8663494
uniprot
proteins
pubmed
8906617
uniprot
proteins
pubmed
9009220
uniprot
proteins
pubmed
9203638
uniprot
proteins
sequence_length
498
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synaptic cell membrane {ECO:0000250|UniProtKB:P04757}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P04757}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 240..255; /note="Helical"; /evidence="ECO:0000269|PubMed:31488329, ECO:0007744|PDB:6PV7, ECO:0007744|PDB:6PV8"; TRANSMEM 262..277; /note="Helical"; /evidence="ECO:0000269|PubMed:31488329, ECO:0007744|PDB:6PV7, ECO:0007744|PDB:6PV8"; TRANSMEM 297..321; /note="Helical"; /evidence="ECO:0000269|PubMed:31488329, ECO:0007744|PDB:6PV7, ECO:0007744|PDB:6PV8"; TRANSMEM 455..478; /note="Helical"; /evidence="ECO:0000269|PubMed:31488329, ECO:0007744|PDB:6PV7, ECO:0007744|PDB:6PV8
uniprot
proteins