Fzd2
entrez
64512
canonical
uniprot
Q08464
canonical
ensembl
ENSRNOG00000021962
resolver
ensp
ENSRNOP00000036154
resolver
ensp
ENSRNOP00000112818
resolver
enst
ENSRNOT00000032944
resolver
enst
ENSRNOT00000145471
resolver
genesymbol
Fzd2
resolver
uniprot
G3V954
resolver
uniprot_entry
FZD2_RAT
resolver
uniprot_entry
G3V954_RAT
resolver
amino_acid_sequence
MRARSALPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGTPALLTTAPPSGLQPGAGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSHHHTRFARLWILTWSVLCCASTFFTVTTSLVAMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGYRTVGQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHAAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNRLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEPLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRTSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSRHGETTV
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G protein-dependent mechanism. {ECO:0000250|UniProtKB:Q14332}.
uniprot
proteins
mass_dalton
63885
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
10395542
uniprot
proteins
pubmed
1334084
uniprot
proteins
sequence_length
570
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 253..273; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 285..305; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 333..353; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 376..396; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 420..440; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 467..487; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 525..545; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins