Q8VHX2
uniprot
Q8VHX2
canonical
amino_acid_sequence
MASPDDPLRSDHMAKEPVEDTDPSTLSFAMSDKYPIQDTGLPKAKECDTVNSNCPPNSDDQPQGEENDFPDSTKDPLSGVSRNQPCKDRKGSCSCPSCSPRAPTISDLLNDQDLLDTIRIKLDPCHPTVKNWRNFASKWGMPYDELCFLEQRPQSPTLEFLFRNSQRTVGQLMELCRLYHRADVEKILRRWVDEEWPHRGHSDSSMHF
uniprot
proteins
function
FUNCTION: Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B (By similarity). {ECO:0000250, ECO:0000269|PubMed:11882293}.
uniprot
proteins
mass_dalton
23753
uniprot
proteins
mutagenesis
MUTAGEN 145; /note="E->K: Reduces binding to EDAR."; /evidence="ECO:0000269|PubMed:11780064
uniprot
proteins
pubmed
11780064
uniprot
proteins
pubmed
11882293
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins