RPL21
entrez
6144
canonical
uniprot
P46778
canonical
ensembl
ENSG00000122026
resolver
ensp
ENSP00000346027
resolver
ensp
ENSP00000351021
resolver
ensp
ENSP00000370569
resolver
ensp
ENSP00000370574
resolver
ensp
ENSP00000577130
resolver
ensp
ENSP00000577131
resolver
ensp
ENSP00000609490
resolver
ensp
ENSP00000609493
resolver
enst
ENST00000272274
resolver
enst
ENST00000311549
resolver
enst
ENST00000319826
resolver
enst
ENST00000326092
resolver
enst
ENST00000907071
resolver
enst
ENST00000907072
resolver
enst
ENST00000939431
resolver
enst
ENST00000939434
resolver
genesymbol
RPL21
resolver
hgnc
HGNC:10313
resolver
uniprot
Q16699
resolver
uniprot
Q6IAX2
resolver
uniprot_entry
Q6IAX2_HUMAN
resolver
uniprot_entry
RL21_HUMAN
resolver
uniprot_sec
Q16699
resolver
amino_acid_sequence
MTNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKGMPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKSRDSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELLEPIPYEFMA
uniprot
proteins
disease_involvement
DISEASE: Hypotrichosis 12 (HYPT12) [MIM:615885]: A form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT12 patients have normal scalp hair density at birth. Hair loss begins during the first 6 months of life and gradually progresses to nearly complete loss of scalp hair. The remaining hairs grow slowly and are thin, sparse, dry, and fragile. Body hair, axillary and pubic hair, eyebrows and eyelashes are also sparse or absent. HYPT12 inheritance is autosomal dominant. {ECO:0000269|PubMed:21412954}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}.
uniprot
proteins
mass_dalton
18565
uniprot
proteins
protein_family
Eukaryotic ribosomal protein eL21 family
uniprot
proteins
pubmed
11875025
uniprot
proteins
pubmed
12962325
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21412954
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23636399
uniprot
proteins
pubmed
24524803
uniprot
proteins
pubmed
25901680
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
25957688
uniprot
proteins
pubmed
32669547
uniprot
proteins
pubmed
7581362
uniprot
proteins
pubmed
7772601
uniprot
proteins
pubmed
7951316
uniprot
proteins
pubmed
9582194
uniprot
proteins
sequence_length
160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P49666}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P49666, ECO:0000269|PubMed:25957688}.
uniprot
proteins