Nemp1
entrez
210035
canonical
uniprot
Q6ZQE4
canonical
ensembl
ENSMUSG00000040195
resolver
ensp
ENSMUSP00000045988
resolver
ensp
ENSMUSP00000113337
resolver
enst
ENSMUST00000048099
resolver
enst
ENSMUST00000118612
resolver
genesymbol
Nemp1
resolver
genesymbol_syn
BC030440
resolver
genesymbol_syn
Kiaa0286
resolver
genesymbol_syn
Tmem194
resolver
genesymbol_syn
Tmem194a
resolver
uniprot
F7CHF5
resolver
uniprot
Q8K2N3
resolver
uniprot_entry
F7CHF5_MOUSE
resolver
uniprot_entry
NEMP1_MOUSE
resolver
uniprot_entry
Q8K2N3_MOUSE
resolver
amino_acid_sequence
MAGGIKVSVWSAVGPGPRCWGAGGGGGATWLLLVVAGCVVCGSADVNVVMLQESQVDMNSSQQFCYKNVLIPKWHDIWTRIQVRVNSSKLVRVTQVDNEEKLKELEQFSIWNFFSSFLKEKLNDTYVNVGLYSTKTCLKVEMIEKDTTYSVTVTRRFDPKLFLVFLLGLTLFFCGDLLSRSQIFYYSTGMSVGIVASLLIVIFMISKFMPKRSPIYVILVGGWSFSLYLIQLVFKNLQEIWRSYWHYLLSYILTVGFMSFAVCYKYGPLENERSINLLTWTLQLLGLGLMYSSIQIPHVAFALIVIALCTKNLEYPIHWLCSTYRRMCKASGKPVPPRLLTEEEYRIQGEVETQKALQELREFCNSPECSAWKTISRIQSPKRFADFVEGSFHLTPNEVSVHEQEYGLGSIFTQDEELSSEEEGSEYPTFTQNNFLT
uniprot
proteins
function
FUNCTION: Together with EMD, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). Required for female fertility (PubMed:32923640). Essential for normal erythropoiesis (PubMed:36215313). Required for efficient nuclear envelope opening and enucleation during the late stages of erythroblast maturation (PubMed:36215313). {ECO:0000269|PubMed:32923640, ECO:0000269|PubMed:36215313}.
uniprot
proteins
mass_dalton
49817
uniprot
proteins
mutagenesis
MUTAGEN 366; /note="S->A,E: Partial loss of phosphorylation and loss of interaction with RAN-GTP; when associated with A/E-376; A/E-380; A/E-419 and A/E-420."; /evidence="ECO:0000269|PubMed:25946333"; MUTAGEN 376; /note="S->A,E: Partial loss of phosphorylation and loss of interaction with RAN-GTP; when associated with A/E-366; A/E-380; A/E-419 and A/E-420."; /evidence="ECO:0000269|PubMed:25946333"; MUTAGEN 380; /note="S->A,E: Partial loss of phosphorylation and loss of interaction with RAN-GTP; when associated with A/E-366; A/E-376; A/E-419 and A/E-420."; /evidence="ECO:0000269|PubMed:25946333"; MUTAGEN 419; /note="S->A,E: Partial loss of phosphorylation and loss of interaction with RAN; when associated with A/E-366; A/E-376; A/E-380 and A/E-420."; /evidence="ECO:0000269|PubMed:25946333"; MUTAGEN 420; /note="S->A,E: Partial loss of phosphorylation and loss of interaction with RAN-GTP; when associated with A/E-366; A/E-376; A/E-380 and A/E-419."; /evidence="ECO:0000269|PubMed:25946333
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation may regulate its interaction with RAN-GTP. {ECO:0000269|PubMed:25946333}.
uniprot
proteins
protein_family
NEMP family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
25946333
uniprot
proteins
pubmed
32923640
uniprot
proteins
pubmed
36215313
uniprot
proteins
sequence_length
437
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:25946333}; Multi-pass membrane protein {ECO:0000255}; Nucleoplasmic side {ECO:0000250|UniProtKB:B9X187}. Nucleus envelope {ECO:0000269|PubMed:25946333, ECO:0000269|PubMed:36215313}. Note=Colocalizes with lamins and RAN-GTP at the nuclear envelope. {ECO:0000269|PubMed:25946333}.
uniprot
proteins
transmembrane_region
TRANSMEM 159..179; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 244..264; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 288..308; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins