Cd3g
entrez
300678
canonical
uniprot
Q64159
canonical
ensembl
ENSRNOG00000015945
resolver
ensp
ENSRNOP00000021390
resolver
enst
ENSRNOT00000021390
resolver
genesymbol
Cd3g
resolver
uniprot
F1M9F8
resolver
uniprot_entry
CD3G_RAT
resolver
uniprot_entry
F1M9F8_RAT
resolver
amino_acid_sequence
MEQGKGLAGLFLVISLLQGTMAQQKEEKHLVKVDDSQGDGSVLLTCDFNEKTITWLKDGHRISPPNATKSTWNLGNGAKDPRGMYQCRGAKKKSQLLQVYYRLCENCIELNMGTVSGFIFAEIISIFFLAVGVYFIAGQDGVRQSRASDKQTLLQNEQVYQPLKDREYEQYSRLQGNQVRKK
uniprot
proteins
function
FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G. {ECO:0000250|UniProtKB:P09693}.
uniprot
proteins
mass_dalton
20545
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. Phosphorylated also by PKC; leading to the TCR complex down-regulation. {ECO:0000250|UniProtKB:P09693}.; PTM: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. {ECO:0000250|UniProtKB:P04234}.
uniprot
proteins
pubmed
1531205
uniprot
proteins
sequence_length
182
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P09693}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P09693}.
uniprot
proteins
transmembrane_region
TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins