Akr1c21
entrez
77337
canonical
uniprot
Q91WR5
canonical
ensembl
ENSMUSG00000021207
resolver
ensp
ENSMUSP00000021628
resolver
enst
ENSMUST00000021628
resolver
genesymbol
Akr1c21
resolver
uniprot
Q6P8V0
resolver
uniprot
Q9CX32
resolver
uniprot_entry
AK1CL_MOUSE
resolver
uniprot_sec
Q6P8V0
resolver
uniprot_sec
Q9CX32
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by high concentrations of substrate. {ECO:0000269|PubMed:15577209}.
uniprot
proteins
amino_acid_sequence
MNSKCHCVILNDGNFIPVLGFGTALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIFYTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPGEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNKPGLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPVLGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRYIPAAIFKGHPNWPFLDEY
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
ec_number
1.1.1.209
uniprot
proteins
function
FUNCTION: NADP-dependent 17-alpha-hydroxysteroid dehydrogenase that converts 5-alpha-androstane-3,17-dione into androsterone. Has lower 3-alpha-hydroxysteroid dehydrogenase activity. Has broad substrate specificity and acts on various 17-alpha-hydroxysteroids, 17-ketosteroids, 3-alpha hydroxysteroids and 3-ketosteroids. Reduction of keto groups is strictly stereoselective. Reduction of 17-ketosteroids yields only 17-alpha-hydroxysteroids. Likewise, reduction of 3-ketosteroids yields only 3-alpha-hydroxysteroids. {ECO:0000269|PubMed:15577209, ECO:0000269|PubMed:16018803, ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17442338, ECO:0000269|PubMed:20124700}.
uniprot
proteins
mass_dalton
36877
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="A->Y: Reduces enzyme activity and affinity for substrate. Alters the stereospecificity, so that androstenedione is converted to testosterone."; /evidence="ECO:0000269|PubMed:17034817"; MUTAGEN 31; /note="K->A: No effect on affinity for androstenedione. Slight increase of catalytic activity."; /evidence="ECO:0000269|PubMed:17442338"; MUTAGEN 222; /note="Q->N: Decreases affinity for NADP. Changes enzyme activity, leading to the production of testosterone and concomitantly reducing the production of epi-testosterone."; /evidence="ECO:0000269|PubMed:20124700"; MUTAGEN 224; /note="Y->D: Decreases affinity for NADP. Changes enzyme activity, leading to the production of testosterone and concomitantly reducing the production of epi-testosterone."; /evidence="ECO:0000269|PubMed:20124700"; MUTAGEN 224; /note="Y->F: No effect on enzyme activity. Decreases affinity for NADP."; /evidence="ECO:0000269|PubMed:20124700
uniprot
proteins
protein_family
Aldo/keto reductase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15577209
uniprot
proteins
pubmed
16018803
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17034817
uniprot
proteins
pubmed
17442338
uniprot
proteins
pubmed
17909281
uniprot
proteins
pubmed
19237748
uniprot
proteins
pubmed
20124700
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins