Hes1
entrez
15205
canonical
uniprot
P35428
canonical
ensembl
ENSMUSG00000022528
resolver
ensp
ENSMUSP00000023171
resolver
ensp
ENSMUSP00000185339
resolver
ensp
ENSMUSP00000185340
resolver
enst
ENSMUST00000023171
resolver
genesymbol
Hes1
resolver
genesymbol_syn
Hes-1
resolver
uniprot
Q3UZZ2
resolver
uniprot_entry
HES1_MOUSE
resolver
uniprot_entry
Q3UZZ2_MOUSE
resolver
amino_acid_sequence
MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAHPALQAPPPPPPSGPAGPQHAPFAPPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTSDSMWRPWRN
uniprot
proteins
function
FUNCTION: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
29749
uniprot
proteins
pubmed
10851137
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7906273
uniprot
proteins
pubmed
9874198
uniprot
proteins
sequence_length
282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins