Phox2a
entrez
11859
canonical
uniprot
Q62066
canonical
ensembl
ENSMUSG00000007946
resolver
ensp
ENSMUSP00000008090
resolver
enst
ENSMUST00000008090
resolver
genesymbol
Phox2a
resolver
genesymbol_syn
Arix
resolver
genesymbol_syn
Phox2
resolver
genesymbol_syn
Pmx2
resolver
genesymbol_syn
Pmx2a
resolver
uniprot_entry
PHX2A_MOUSE
resolver
amino_acid_sequence
MDYSYLNSYDSCVAAMEASAYGDFGACSQPGGFQYSPLRPAFPAAGPPCPALGSSNCALGALRDHQPAPYSAVPYKFFPEPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAASAKGAAGATGAKKGEARCSSEDDDSKESTCSPTPDSTASLPPPPAPSLASPRLSPSPLPAALGSGPGPQPLKGALWAGVAGGGGGGPGTGAAELLKAWQPAEPGPGPFSGVLSSFHRKPGPALKTNLF
uniprot
proteins
function
FUNCTION: May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus (PubMed:32094113). Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype. {ECO:0000269|PubMed:32094113}.
uniprot
proteins
mass_dalton
29417
uniprot
proteins
mutagenesis
MUTAGEN 178; /note="K->R: Complete loss of monoubiquitination."; /evidence="ECO:0000269|PubMed:32094113
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated at Lys-178 by the RNF220/ZC4H2 complex; leading to enhanced DNA-binding ability and transactivity. {ECO:0000269|PubMed:32094113}.
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
32094113
uniprot
proteins
pubmed
7910552
uniprot
proteins
sequence_length
280
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
uniprot
proteins