COX2
entrez
4513
canonical
uniprot
P00403
canonical
ensembl
ENSG00000198712
resolver
ensp
ENSP00000354876
resolver
enst
ENST00000361739
resolver
genesymbol
COX2
resolver
genesymbol
MT-CO2
resolver
genesymbol_syn
CO2
resolver
genesymbol_syn
COII
resolver
genesymbol_syn
COX2
resolver
genesymbol_syn
COXII
resolver
genesymbol_syn
MTCO2
resolver
hgnc
HGNC:7421
resolver
uniprot
A0A1B0VYS2
resolver
uniprot
A0A1X7RBF7
resolver
uniprot
Q37526
resolver
uniprot
U5Z487
resolver
uniprot_entry
COX2_HUMAN
resolver
uniprot_entry
U5Z487_HUMAN
resolver
uniprot_sec
A0A1B0VYS2
resolver
uniprot_sec
A0A1X7RBF7
resolver
uniprot_sec
Q37526
resolver
amino_acid_sequence
MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL
uniprot
proteins
disease_involvement
DISEASE: Mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]: A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and intellectual disability. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal death. A subset of patients manifest Leigh syndrome. {ECO:0000269|PubMed:10486321}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
7.1.1.9
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00410}.
uniprot
proteins
mass_dalton
25565
uniprot
proteins
protein_family
Cytochrome c oxidase subunit 2 family
uniprot
proteins
pubmed
10486321
uniprot
proteins
pubmed
11130070
uniprot
proteins
pubmed
12840039
uniprot
proteins
pubmed
12949126
uniprot
proteins
pubmed
14760490
uniprot
proteins
pubmed
1757091
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
226894
uniprot
proteins
pubmed
23125284
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24403053
uniprot
proteins
pubmed
2550900
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28330871
uniprot
proteins
pubmed
28844695
uniprot
proteins
pubmed
29154948
uniprot
proteins
pubmed
29355485
uniprot
proteins
pubmed
29381136
uniprot
proteins
pubmed
30030519
uniprot
proteins
pubmed
35750769
uniprot
proteins
pubmed
7219534
uniprot
proteins
pubmed
7530363
uniprot
proteins
pubmed
8277847
uniprot
proteins
pubmed
9806551
uniprot
proteins
sequence_length
227
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519, ECO:0000305|PubMed:35750769}; Multi-pass membrane protein {ECO:0000269|PubMed:30030519}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..45; /note="Helical; Name=I"; /evidence="ECO:0000250|UniProtKB:P68530"; TRANSMEM 60..87; /note="Helical; Name=II"; /evidence="ECO:0000250|UniProtKB:P68530
uniprot
proteins