Calcoco1
entrez
67488
canonical
uniprot
Q8CGU1
canonical
ensembl
ENSMUSG00000023055
resolver
ensp
ENSMUSP00000023818
resolver
ensp
ENSMUSP00000301729
resolver
enst
ENSMUST00000023818
resolver
genesymbol
Calcoco1
resolver
genesymbol_syn
CocoA
resolver
genesymbol_syn
Kiaa1536
resolver
uniprot
Q5DTX0
resolver
uniprot
Q9D935
resolver
uniprot_entry
CACO1_MOUSE
resolver
uniprot_sec
Q5DTX0
resolver
uniprot_sec
Q9D935
resolver
amino_acid_sequence
MEESSLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTTDGSPTHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEDQVTELRSRVQELEAALATARQEHSELTEQYKGLSRSHGELSEERDILSQQQGDHVARILELEDDIQTMSDKVLMKEVELDRVRDTVKALTREQEKLLRQLKEFQADKEQSEAELQTVREENCCLNTELEEAKSRQEEQGAQVQRLKDKLAHMKDTLGQAQQKVAELEPLKEQLRGVQELAASSQQKAALLGEELASAAGARDRTIAELHRSRLEVAEVNGRLAELSLHMKEEKCQWSKERTGLLQSMEAEKDKILKLSAEILRLEKTVQEERTQSHVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQTEKQELLEYMRKLEARLEKVADEKWTEDAATEDEEATAGLSCPASLTDSEDESPEDMRLPSYGLCESGNTSSSPPGPREPSSLVVINQPAPIAPQFSGPGEASSSDSEAEDEKSVLMAAVQSGGEEASLLLPELGSAFYDVASAFTVSSLSEASPGVPANPPWKECPICKERFPAESDKDALEGHMDGHFFFSTQDPFTFE
uniprot
proteins
function
FUNCTION: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:14690606, ECO:0000269|PubMed:16931570, ECO:0000269|PubMed:24245781}.
uniprot
proteins
mass_dalton
77280
uniprot
proteins
mutagenesis
MUTAGEN 17; /note="F->A: Loss of interaction with p300 KIX domain; eliminated the autonomous transactivation function."; /evidence="ECO:0000269|PubMed:16931570"; MUTAGEN 20; /note="V->A: Reduced binding to p300 KIX domain; severe reduction in the autonomous transactivation function."; /evidence="ECO:0000269|PubMed:16931570"; MUTAGEN 20; /note="V->P: Reduced binding to p300 KIX domain; severe reduction in the autonomous transactivation function."; /evidence="ECO:0000269|PubMed:16931570
uniprot
proteins
protein_family
CALCOCO family
uniprot
proteins
pubmed
14690606
uniprot
proteins
pubmed
15383530
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15522220
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16344550
uniprot
proteins
pubmed
16931570
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24245781
uniprot
proteins
sequence_length
691
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16931570}. Nucleus {ECO:0000269|PubMed:16931570}. Note=Shuttles between nucleus and cytoplasm.
uniprot
proteins