DAPK2
entrez
23604
canonical
uniprot
Q9UIK4
canonical
ensembl
ENSG00000035664
resolver
ensp
ENSP00000408277
resolver
ensp
ENSP00000484390
resolver
ensp
ENSP00000652122
resolver
ensp
ENSP00000684679
resolver
ensp
ENSP00000684686
resolver
ensp
ENSP00000684691
resolver
ensp
ENSP00000684711
resolver
genesymbol
DAPK2
resolver
hgnc
HGNC:2675
resolver
uniprot
E9JGM7
resolver
uniprot
O75892
resolver
uniprot
Q1RMF4
resolver
uniprot
Q24JS1
resolver
uniprot_entry
DAPK2_HUMAN
resolver
uniprot_entry
Q1RMF4_HUMAN
resolver
uniprot_sec
E9JGM7
resolver
uniprot_sec
O75892
resolver
uniprot_sec
Q24JS1
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Regulated by a double locking mechanism, involving autophosphorylation at Ser-318, calmodulin binding, and dimerization. In the inactive state, Ser-318 is phosphorylated, and the kinase is dimeric. Activation involves: dephosphorylation at Ser-318, release-of-autoinhibition mechanism where calmodulin binding induces a conformational change that relieves the steric block of the active site by the autoinhibitory domain, and generation of the monomeric active form of the kinase. {ECO:0000269|PubMed:10376525}.
uniprot
proteins
amino_acid_sequence
MFQASMRSPNMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRRESVVNLENFRKQYVRRRWKLSFSIVSLCNHLTRSLMKKVHLRPDEDLRNCESDTEEDIARRKALHPRRRSSTS
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421). {ECO:0000269|PubMed:17347302, ECO:0000269|PubMed:24163421, ECO:0000269|PubMed:26047703}.; FUNCTION: Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.
uniprot
proteins
mass_dalton
42898
uniprot
proteins
mutagenesis
MUTAGEN 52; /note="K->A: Loss of activity, apoptotic function and of autophosphorylation."; /evidence="ECO:0000269|PubMed:10376525, ECO:0000269|PubMed:10629061, ECO:0000269|PubMed:11230133"; MUTAGEN 299..330; /note="Missing: Loss of ca(2+)-calmodulin binding, increase in activity, loss of autophosphorylation."; MUTAGEN 299; /note="S->A: No effect on Ca(2+)-calmodulin independent phosphorylation or apoptotic activity."; /evidence="ECO:0000269|PubMed:11230133"; MUTAGEN 318; /note="S->A: Loss of Ca(2+)-calmodulin independent phosphorylation, increase in apoptotic activity."; /evidence="ECO:0000269|PubMed:11230133"; MUTAGEN 318; /note="S->D: Abolishes apoptotic activity."; /evidence="ECO:0000269|PubMed:11230133"; MUTAGEN 320; /note="S->A: No effect on Ca(2+)-calmodulin independent phosphorylation or apoptotic activity."; /evidence="ECO:0000269|PubMed:11230133"; MUTAGEN 323; /note="S->A: No effect on Ca(2+)-calmodulin independent phosphorylation or apoptotic activity."; /evidence="ECO:0000269|PubMed:11230133"; MUTAGEN 329; /note="T->A: No effect on Ca(2+)-calmodulin independent phosphorylation or apoptotic activity."; /evidence="ECO:0000269|PubMed:11230133"; MUTAGEN 367; /note="S->A: No effect on interaction with YWHAE."; /evidence="ECO:0000269|PubMed:26047703"; MUTAGEN 368; /note="S->A: No effect on interaction with YWHAE."; /evidence="ECO:0000269|PubMed:26047703"; MUTAGEN 369; /note="T->A: Interaction with YWHAE is reduced."; /evidence="ECO:0000269|PubMed:26047703"; MUTAGEN 370; /note="S->A: Interaction with YWHAE is increased."; /evidence="ECO:0000269|PubMed:26047703
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to activated Fas and TNF receptors. {ECO:0000269|PubMed:11230133}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
DAP kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10376525
uniprot
proteins
pubmed
10629061
uniprot
proteins
pubmed
11230133
uniprot
proteins
pubmed
11980920
uniprot
proteins
pubmed
12445458
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
16756490
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17347302
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18957423
uniprot
proteins
pubmed
21408167
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24163421
uniprot
proteins
pubmed
26047703
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic vesicle, autophagosome lumen.
uniprot
proteins