S100b
entrez
20203
canonical
uniprot
P50114
canonical
ensembl
ENSMUSG00000033208
resolver
ensp
ENSMUSP00000047968
resolver
enst
ENSMUST00000036387
resolver
genesymbol
S100b
resolver
uniprot
Q3UY00
resolver
uniprot_entry
Q3UY00_MOUSE
resolver
uniprot_entry
S100B_MOUSE
resolver
amino_acid_sequence
MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDEDGDGECDFQEFMAFVAMVTTACHEFFEHE
uniprot
proteins
function
FUNCTION: Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (By similarity). Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer (By similarity). Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites (By similarity). Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation (PubMed:2592414, PubMed:8202493). Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue (PubMed:31043739). Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase (By similarity). Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity). May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity). {ECO:0000250|UniProtKB:P02638, ECO:0000250|UniProtKB:P04271, ECO:0000250|UniProtKB:P04631, ECO:0000269|PubMed:2592414, ECO:0000269|PubMed:31043739, ECO:0000269|PubMed:8202493}.
uniprot
proteins
mass_dalton
10728
uniprot
proteins
protein_family
S-100 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2592414
uniprot
proteins
pubmed
31043739
uniprot
proteins
pubmed
8202493
uniprot
proteins
pubmed
8376406
uniprot
proteins
sequence_length
92
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P04271}. Nucleus {ECO:0000250|UniProtKB:P04271}. Secreted {ECO:0000269|PubMed:31043739}. Note=Secretion into the medium is promoted by interaction with isoform CLSTN3beta of CLSTN3. {ECO:0000269|PubMed:31043739}.
uniprot
proteins