P69526
uniprot
P69526
canonical
activity_regulation
ACTIVITY REGULATION: Inhibited by serine protease inhibitors PMSF and 4-(2-aminoethyl)benzenesulfonyl fluoride, but not by EDTA. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MEPAAPDLQPVPEVTKGVPVPTPDSGCCRAAVTTVVAISVASLTLGVLSAFLSAQGVQVEHTAQLHGVRFTSLLQQENSDFYRLLTPALQTLLHFLLRALQPLSLDQEADILQKGIQARLQGQGLSLAAYGTITSVELTGRCEGPVTERDLKSGHCPGNAFSCQNSQCVSKENPECDDRVDCSDGSDEAQCDCGWQPAWRSAGRIVGGAEAAPGEFPWQVSLRENHEHFCGATIIGARWLVSAAHCFNEFQDPAQWAAQAGSVHLSGSEASAVRARVLRIAKHPAYNADTADFDVAVLELARPLPFGRYVQPACLPAATHVFPPRKKCLISGWGYLKEDFLVKPEVLQKATVELLDQNLCSSLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGVVSWGIGCAEARRPGVYTRVTRLRDWILEVTSSADTPVVPTEAPAPITPSTPWPTSPESRVPNTTAKPTVAPTPAPLHPSTAAKPQECGARPAMDKPTRIVGGISAVSGEVPWQASLKEGSRHFCGATVVGDRWLLSAAHCFNHTKLEQVQAHLGTVSLLGVGGSPVKLGLRSVALHPRYNPGILDFDVALLELAQPLVFNKYIQPVCLPLAIHKFPVGRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALYNFSLTDRMLCAGFLEGRVDSCQGDSGGPLACEETPGVFYLAGIVSWGIGCAQAKKPGVYARITRLKDWILKAMSSDPSSTAHPHTSSTRLIPSQPPTTTAAGLIPEASTGRPATLRATIRVTTRPLNTTLSARSTTTRRQTPAPGTTVFSHLPDCGLAPPGALTRIVGGSAASLGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPMQWAAFLGTPFLSSTEGQLERVARIYRHPFYNIYTLDYDVALLELAGPVRRSRLVRPICLPGPTRPPEGARCVITGWGSLREGGSMARQLQKAAVRVLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGQWVLTGVTSWGYGCGRPHFPGVYTRVAAVLGWIGQNIRE
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
113890
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved to generate 3 independent serine protease chains. The cleaved chains may remain attached to the membrane thanks to disulfide bonds. It is unclear whether cleavage always takes place (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
12886014
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
1061
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins