RBKS
entrez
64080
canonical
uniprot
Q9H477
canonical
ensembl
ENSG00000171174
resolver
ensp
ENSP00000306817
resolver
genesymbol
RBKS
resolver
genesymbol_syn
RBSK
resolver
hgnc
HGNC:30325
resolver
uniprot
A9UK04
resolver
uniprot
B4DV96
resolver
uniprot_entry
RBSK_HUMAN
resolver
uniprot_sec
A9UK04
resolver
uniprot_sec
B4DV96
resolver
activity_regulation
ACTIVITY REGULATION: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity (By similarity). Competitively inhibited by phosphonoacetic acid, etidronate, 2-carboxethylphosphonic acid, N-(phosphonomethyl)glycine, N-(phosphonomethyl)iminodiacetic acid and clodronate (PubMed:17585908). {ECO:0000255|HAMAP-Rule:MF_03215, ECO:0000269|PubMed:17585908}.
uniprot
proteins
amino_acid_sequence
MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLPLTLF
uniprot
proteins
ec_number
2.7.1.15
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. {ECO:0000255|HAMAP-Rule:MF_03215, ECO:0000269|PubMed:17585908}.
uniprot
proteins
mass_dalton
34143
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2. {ECO:0000255|HAMAP-Rule:MF_03215}.
uniprot
proteins
protein_family
Carbohydrate kinase PfkB family
uniprot
proteins
protein_family
Ribokinase subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17585908
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P25332, ECO:0000255|HAMAP-Rule:MF_03215}. Nucleus {ECO:0000250|UniProtKB:P25332, ECO:0000255|HAMAP-Rule:MF_03215}.
uniprot
proteins