Mims2
entrez
67017
canonical
uniprot
Q9D8B6
canonical
ensembl
ENSMUSG00000027495
resolver
ensp
ENSMUSP00000028995
resolver
enst
ENSMUST00000028995
resolver
genesymbol
Mims2
resolver
genesymbol_syn
Fam210b
resolver
uniprot
Q3UFZ3
resolver
uniprot
Q91WA2
resolver
uniprot_entry
MIMS2_MOUSE
resolver
uniprot_sec
Q3UFZ3
resolver
uniprot_sec
Q91WA2
resolver
amino_acid_sequence
MAGLLTLLGPAGRVSTRLRPLAPWLLGTATSCAPPLWALALSHPVPDARLLRTARGDCLSRQEPNRTPEPGGSVTGTEKKLSRTQQLKKVFQEYGAVGVSMHIGISLVSLGIFYTVVSSGIDMSAILLKLGFKESLVQSKMAAGTSTFVVAYAIHKLFAPVRISITLVSVPFVVRYFRSVGLFKPPATKP
uniprot
proteins
function
FUNCTION: Mitochondrial inner membrane adapter protein essential for terminal erythroid differentiation and heme biosynthesis (PubMed:30366982). Facilitates formation of an oligomeric mitochondrial iron transport complex required for iron acquisition during heme synthesis, although it does not function as a direct iron transporter (PubMed:30366982). Directly interacts with terminal heme synthesis enzymes PPOX and FECH to enhance ferrochelatase activity and couple iron import with heme synthesis (PubMed:30366982). Regulates mitochondrial energy metabolism through interaction with ATP synthase subunits (By similarity). {ECO:0000250|UniProtKB:Q96KR6, ECO:0000269|PubMed:30366982}.
uniprot
proteins
mass_dalton
20344
uniprot
proteins
protein_family
MIMS family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26968549
uniprot
proteins
pubmed
30366982
uniprot
proteins
sequence_length
190
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30366982}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 97..117; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 148..168; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins