RANGRF
entrez
29098
canonical
uniprot
Q9HD47
canonical
ensembl
ENSG00000108961
resolver
ensp
ENSP00000226105
resolver
ensp
ENSP00000383940
resolver
ensp
ENSP00000413190
resolver
ensp
ENSP00000462310
resolver
genesymbol
RANGRF
resolver
genesymbol_syn
MOG1
resolver
genesymbol_syn
RANGNRF
resolver
hgnc
HGNC:17679
resolver
uniprot
D3DTR6
resolver
uniprot
Q68DI3
resolver
uniprot
Q9BR68
resolver
uniprot
Q9HD48
resolver
uniprot
Q9NRU9
resolver
uniprot
Q9P001
resolver
uniprot
Q9P0P2
resolver
uniprot_entry
MOG1_HUMAN
resolver
uniprot_sec
D3DTR6
resolver
uniprot_sec
Q68DI3
resolver
uniprot_sec
Q9BR68
resolver
uniprot_sec
Q9HD48
resolver
uniprot_sec
Q9NRU9
resolver
uniprot_sec
Q9P001
resolver
uniprot_sec
Q9P0P2
resolver
amino_acid_sequence
MEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSLENLALRGRCQEAWVLSGKQQIAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPPDNRSSLGPENLSPAPWSLGDFEQLVTSLTLHDPNIFGPQ
uniprot
proteins
function
FUNCTION: May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:21621375, PubMed:23420830). {ECO:0000269|PubMed:11290418, ECO:0000269|PubMed:18184654, ECO:0000269|PubMed:21621375, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:29040603}.
uniprot
proteins
mass_dalton
20448
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="D->K: Decreased binding to RAN."; /evidence="ECO:0000269|PubMed:29040603"; MUTAGEN 50; /note="E->K: Strongly decreased binding to RAN. Abolishes binding to RAN; when associated with K-53."; /evidence="ECO:0000269|PubMed:29040603"; MUTAGEN 53; /note="E->K: Decreased binding to RAN. Abolishes binding to RAN; when associated with K-50."; /evidence="ECO:0000269|PubMed:29040603"; MUTAGEN 70; /note="D->K: Decreased binding to RAN."; /evidence="ECO:0000269|PubMed:29040603
uniprot
proteins
protein_family
MOG1 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11290418
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18184654
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21447824
uniprot
proteins
pubmed
21621375
uniprot
proteins
pubmed
23420830
uniprot
proteins
pubmed
24142675
uniprot
proteins
pubmed
29040603
uniprot
proteins
sequence_length
186
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11290418}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21447824}. Cytoplasm {ECO:0000269|PubMed:11290418, ECO:0000269|PubMed:21447824}. Cell membrane {ECO:0000269|PubMed:21447824}; Peripheral membrane protein {ECO:0000305|PubMed:21447824}; Cytoplasmic side {ECO:0000305|PubMed:21447824}. Note=May shuttle between the nucleus and cytoplasm. {ECO:0000269|PubMed:11290418}.
uniprot
proteins