Septin12
entrez
363542
canonical
uniprot
Q4V8G5
canonical
ensembl
ENSRNOG00000003137
resolver
ensembl
ENSRNOG00055028745
resolver
ensembl
ENSRNOG00060007055
resolver
ensembl
ENSRNOG00065010031
resolver
ensp
ENSRNOP00000057921
resolver
ensp
ENSRNOP00000088547
resolver
ensp
ENSRNOP00055040987
resolver
ensp
ENSRNOP00060008720
resolver
ensp
ENSRNOP00065012233
resolver
enst
ENSRNOT00000061208
resolver
enst
ENSRNOT00000111695
resolver
enst
ENSRNOT00055049789
resolver
enst
ENSRNOT00060011602
resolver
enst
ENSRNOT00065016144
resolver
genesymbol
Septin12
resolver
genesymbol_syn
Sept12
resolver
uniprot
A0A8I6A6R7
resolver
uniprot_entry
A0A8I6A6R7_RAT
resolver
uniprot_entry
SEP12_RAT
resolver
amino_acid_sequence
MDERRTPSPCSSRPSSPRTPPCEMFGPVGIEAVLDQLRIKAMKTGFEFNIMVVGQSGLGKSTMVNTLFKSKVWQSPAPNLDVPMPQTLELHSVTHVIEEKGLKLKLTVTDTPGFGDQINNDKCWDPILSYINQQYEQYLQEELLITRQRHIPDTRVHCCVYFVPPTGHCLRPLDIEFLRRLCRTVNVVPVIARADSLTIEERDAFRSRIQQNLKNHCIDVYPQQCFDEDINDRLLNSKIREQIPFAVVGADREHIVNGRCVLGRKTKWGIIEVENMAHCEFLLLRDLLIRSHLQDLKDITHNVHYENYRVLRLNESHVLPRGPGWVNLAPASPGQLMAPGPEKVRKRSKDPRDDEC
uniprot
proteins
function
FUNCTION: Filament-forming cytoskeletal GTPase (By similarity). Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (By similarity). Facilitates the formation of Septin filament structures with SEPTIN7, SEPTIN6, SEPTIN2 and SEPTIN4 at the sperm annulus (By similarity). Correct formation of the annulus is required for development of normal structural morphology and motility of the sperm during steps 13 to 16 of spermiogenesis (By similarity). Essential component of the LMNB1/SUN5/SEPT12 bridge that connects the sperm proximal centriole to the implantation fossa, the bridge functions to prevent detachment of the proximal centriole from the posterior nucleus during spermiogenesis (By similarity). Required for PLCZ1 localization at the sperm acrosome during spermiogenesis (By similarity). May also play a role in the initiation of calcium oscillations in embryos (By similarity). {ECO:0000250|UniProtKB:A0A2R8VJU7, ECO:0000250|UniProtKB:Q8IYM1, ECO:0000250|UniProtKB:Q9NVA2}.
uniprot
proteins
mass_dalton
40799
uniprot
proteins
mutagenesis
MUTAGEN 61; /note="S->N: Abolishes homodimerization."; /evidence="ECO:0000269|PubMed:17685441
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-196; by PRKACA; results in inhibition of Septin ring formation and as a result annulus formation during spermiogenesis. {ECO:0000250|UniProtKB:A0A2R8VJU7}.
uniprot
proteins
protein_family
Septin GTPase family
uniprot
proteins
protein_family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17685441
uniprot
proteins
sequence_length
356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q8IYM1, ECO:0000250|UniProtKB:Q9D451, ECO:0000269|PubMed:17685441}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:A0A2R8VJU7}. Note=At interphase, forms a filamentous structure in the cytoplasm. During anaphase, translocates to the central spindle region and to the midbody during cytokinesis. Colocalized with SPAG4 at the nuclear periphery in round spermatids (By similarity). During sperm head formation in elongating spermatids, expressed at the acrosome, perinuclear mantle of the manchette structure and the sperm neck (By similarity). Expressed at mitochondrial materials in elongating spermatids (By similarity). Expressed in mature sperm at the annulus, neck and tail (PubMed:17685441). Expressed at the midpiece in ejaculated mature sperm (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:A0A2R8VJU7, ECO:0000250|UniProtKB:Q8IYM1, ECO:0000269|PubMed:17685441}.
uniprot
proteins