PPTC7
entrez
160760
canonical
uniprot
Q8NI37
canonical
ensembl
ENSG00000196850
resolver
ensp
ENSP00000346255
resolver
ensp
ENSP00000728467
resolver
ensp
ENSP00000728468
resolver
enst
ENST00000354300
resolver
genesymbol
PPTC7
resolver
genesymbol_syn
TAPP2C
resolver
hgnc
HGNC:30695
resolver
uniprot
B3KWC5
resolver
uniprot
Q68DZ7
resolver
uniprot
Q6UY82
resolver
uniprot_entry
PPTC7_HUMAN
resolver
uniprot_sec
B3KWC5
resolver
uniprot_sec
Q68DZ7
resolver
uniprot_sec
Q6UY82
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by sodium orthovanadate. {ECO:0000269|PubMed:30267671}.
uniprot
proteins
amino_acid_sequence
MFSVLSYGRLVARAVLGGLSQTDPRAGGGGGGDYGLVTAGCGFGKDFRKGLLKKGACYGDDACFVARHRSADVLGVADGVGGWRDYGVDPSQFSGTLMRTCERLVKEGRFVPSNPIGILTTSYCELLQNKVPLLGSSTACIVVLDRTSHRLHTANLGDSGFLVVRGGEVVHRSDEQQHYFNTPFQLSIAPPEAEGVVLSDSPDAADSTSFDVQLGDIILTATDGLFDNMPDYMILQELKKLKNSNYESIQQTARSIAEQAHELAYDPNYMSPFAQFACDNGLNVRGGKPDDITVLLSIVAEYTD
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Protein phosphatase that plays an essential role in mitochondrial metabolism and biogenesis (PubMed:30267671). Positively regulates biosynthesis of the ubiquinone, coenzyme Q (PubMed:30267671). Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (PubMed:30267671). Serves as a crucial sensor for mitophagy, though the underlying mechanism remains ambiguous (By similarity). May dephosphorylate BNIP3 and NIX and thereby directly regulates mitophagy receptor function and stability (By similarity). Alternatively, promotes SCF-FBXL4-dependent ubiquitination and degradation of BNIP3 and NIX independently of its catalytic activity to restrain mitophagy (PubMed:38992176). {ECO:0000250|UniProtKB:Q6NVE9, ECO:0000269|PubMed:30267671, ECO:0000269|PubMed:38992176}.
uniprot
proteins
mass_dalton
32646
uniprot
proteins
protein_family
PP2C family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15177553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
29043977
uniprot
proteins
pubmed
30267671
uniprot
proteins
pubmed
38992176
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:30267671}.
uniprot
proteins