GSPT1
entrez
2935
canonical
uniprot
P15170
canonical
ensembl
ENSG00000103342
resolver
ensp
ENSP00000398131
resolver
ensp
ENSP00000399539
resolver
ensp
ENSP00000408399
resolver
genesymbol
GSPT1
resolver
genesymbol_syn
ERF3A
resolver
hgnc
HGNC:4621
resolver
uniprot
B2RCT6
resolver
uniprot
J3KQG6
resolver
uniprot
Q7KZX8
resolver
uniprot
Q96GF2
resolver
uniprot_entry
B2RCT6_HUMAN
resolver
uniprot_entry
ERF3A_HUMAN
resolver
uniprot_entry
Q7KZX8_HUMAN
resolver
uniprot_sec
J3KQG6
resolver
uniprot_sec
Q96GF2
resolver
amino_acid_sequence
MELSEPIVENGETEMSPEESWEHKEEISEAEPGGGSLGDGRPPEESAHEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLKGIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:15987998, PubMed:19417105, PubMed:2511002, PubMed:27863242). GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:27863242). GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (PubMed:16777602, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). {ECO:0000269|PubMed:15987998, ECO:0000269|PubMed:16777602, ECO:0000269|PubMed:19417105, ECO:0000269|PubMed:24486019, ECO:0000269|PubMed:2511002, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:30682371}.
uniprot
proteins
mass_dalton
55756
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
ERF3 subfamily
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
15987998
uniprot
proteins
pubmed
16777602
uniprot
proteins
pubmed
19417104
uniprot
proteins
pubmed
19417105
uniprot
proteins
pubmed
20418951
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24486019
uniprot
proteins
pubmed
2511002
uniprot
proteins
pubmed
27863242
uniprot
proteins
pubmed
30682371
uniprot
proteins
sequence_length
499
uniprot
proteins