Rasgrf1
entrez
192213
canonical
uniprot
P28818
canonical
ensembl
ENSRNOG00000014025
resolver
ensp
ENSRNOP00000077058
resolver
ensp
ENSRNOP00000111797
resolver
enst
ENSRNOT00000106070
resolver
genesymbol
Rasgrf1
resolver
uniprot
A0A8I5Y148
resolver
uniprot
Q5BJV1
resolver
uniprot_entry
A0A8I5Y148_RAT
resolver
uniprot_entry
Q5BJV1_RAT
resolver
uniprot_entry
RGRF1_RAT
resolver
amino_acid_sequence
MQKAIRLNDGHVVSLGLLAQRDGTRKGYLSKRSSDNPKWQTKWFALLQNLLFYFESDSSSRPSGLYLLEGSICKRMPSPKRGTSSKESDKQHHYFTVNFSNDSQKSLELRTDDSKDCDEWVAAIARASYKILATEHEALMQKYLHLLQVVETEKTVAKQLRQQLEDGEVEIERLKAEIANLIKDNERIQSNQLVAPEDEDSDIKKIKKVQSFLRGWLCRRKWKNIIQDYIRSPHADSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLHQIFYQGLKARIASWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLLKQYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELSRVMHDEVSETENIRKNLAIERMITEGCEILLDTSQTFVRQGSLIQVPMSEKGKINKGRLGSLSLKKEGERQCFLFSKHLIICTRGSGSKLHLTKNGVISLIDCTLLDDPENMDDDGKGQEVDHLDFKIWVEPKDSPPFTVILVASSRQEKAAWTSDIIQCVDNIRCNGLMMNAFEENSKVTVPQMIKSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERLTDLRFLSIDFLNTFLHSYRVFTDAVVVLDKLISIYKKPITAIPARSLELLFSSSHNTKLLYGDAPKSPRASRKFSSPPPLAIGTSSPVRRRKLSLNIPIITGGKALELASLGCPSDGYTNIHSPISPFGKTTLDTSKLCVASSLTRTPEEIDMTTLEESSGFRKPTSDILKEESDDDQSDVDDTEVSPPTPKSFRNRITQEFPLFNYNSGIMMTCRDLMDSNRSPLSATSAFAIATAGANESPANKEIYRRMSLANTGYSSDQRNIDKEFVIRRAATNRVLNVLRHWVTKHSQDFETDDLLKYKVICFLEEVMHDPDLLPQERKAAANIMRTLTQEEITENHSMLDELLLMTEGVKTEPFENHSAMEIAEQLTLLDHLVFKSIPYEEFFGQGWMKADKNERTPYIMKTTRHFNHISNLIASEILRNEEVSARASTIEKWVAVADICRCLHNYNAVLEITSSINRSAIFRLKKTWLKVSKQTKSLFDKLQKLVSSDGRFKNLRETLRNCDPPCVPYLGMYLTDLAFLEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTTYKIEPQPKVTQYLVDETFVLDDESLYEASLRIEPKLPT
uniprot
proteins
function
FUNCTION: Promotes the exchange of Ras-bound GDP by GTP. {ECO:0000269|PubMed:10373510}.
uniprot
proteins
mass_dalton
142667
uniprot
proteins
mutagenesis
MUTAGEN 71; /note="S->A: Abolishes degradation by the proteasome."; /evidence="ECO:0000269|PubMed:21382555"; MUTAGEN 575; /note="S->A: Abolishes degradation by the proteasome."; /evidence="ECO:0000269|PubMed:21382555
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome. {ECO:0000269|PubMed:21382555}.; PTM: Ubiquitinated and degraded following phosphorylation by PLK2. {ECO:0000269|PubMed:21382555}.; PTM: Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC does not seem to have an effect on stimulation activity (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
10373510
uniprot
proteins
pubmed
1379346
uniprot
proteins
pubmed
21382555
uniprot
proteins
sequence_length
1244
uniprot
proteins