BROX
entrez
148362
canonical
uniprot
Q5VW32
canonical
ensembl
ENSG00000162819
resolver
ensp
ENSP00000343742
resolver
ensp
ENSP00000398862
resolver
ensp
ENSP00000440041
resolver
ensp
ENSP00000441080
resolver
ensp
ENSP00000478496
resolver
ensp
ENSP00000558472
resolver
ensp
ENSP00000586870
resolver
ensp
ENSP00000586877
resolver
ensp
ENSP00000632666
resolver
ensp
ENSP00000632668
resolver
ensp
ENSP00000632670
resolver
enst
ENST00000537020
resolver
genesymbol
BROX
resolver
genesymbol_syn
BROFTI
resolver
genesymbol_syn
C1orf58
resolver
hgnc
HGNC:26512
resolver
uniprot
B7Z953
resolver
uniprot
B7Z9G5
resolver
uniprot
F5GXQ0
resolver
uniprot
Q96MG1
resolver
uniprot_entry
B7Z953_HUMAN
resolver
uniprot_entry
BROX_HUMAN
resolver
uniprot_entry
F5GXQ0_HUMAN
resolver
uniprot_sec
B7Z9G5
resolver
uniprot_sec
Q96MG1
resolver
amino_acid_sequence
MTHWFHRNPLKATAPVSFNYYGVVTGPSASKICNDLRSSRARLLELFTDLSCNPEMMKNAADSYFSLLQGFINSLDESTQESKLRYIQNFKWTDTLQGQVPSAQQDAVFELISMGFNVALWYTKYASRLAGKENITEDEAKEVHRSLKIAAGIFKHLKESHLPKLITPAEKGRDLESRLIEAYVIQCQAEAQEVTIARAIELKHAPGLIAALAYETANFYQKADHTLSSLEPAYSAKWRKYLHLKMCFYTAYAYCYHGETLLASDKCGEAIRSLQEAEKLYAKAEALCKEYGETKGPGPTVKPSGHLFFRKLGNLVKNTLEKCQRENGFIYFQKIPTEAPQLELKANYGLVEPIPFEFPPTSVQWTPETLAAFDLTKRPKDDSTKPKPEEEVKPVKEPDIKPQKDTGCYIS
uniprot
proteins
function
FUNCTION: Nuclear envelope-associated factor that is involved in the nuclear envelope ruptures during interphase (NERDI) repair, where it is locally recruited by CHMP5 and reduces cytoskeletal stress through its action on SYN2 to help reseal the ruptured membrane. {ECO:0000269|PubMed:34818527}.
uniprot
proteins
mass_dalton
46476
uniprot
proteins
mutagenesis
MUTAGEN 204; /note="H->A: Does not affect SYN2 interaction. Does not induce SYN2 ubiquitination. Does not affect recruitment to sites of rupture. Impairs NE repair."; /evidence="ECO:0000269|PubMed:34818527"; MUTAGEN 350; /note="L->A: Loss of SYN2 interaction. Abolishes BROX recruitment to sites of nuclear envelope (NE) rupture. Impairs NE resealing. Does not induce SYN2 ubiquitination."; /evidence="ECO:0000269|PubMed:34818527"; MUTAGEN 408; /note="C->S: Loss of association with the nuclear envelop. Abolishes its recruitment to rupture sites. Abolishes its repair function."; /evidence="ECO:0000269|PubMed:34818527
uniprot
proteins
post_translational_modification
PTM: Farnesylation is required for nuclear envelope localization. {ECO:0000269|PubMed:34818527}.
uniprot
proteins
protein_family
BROX family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17411337
uniprot
proteins
pubmed
18190528
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21889351
uniprot
proteins
pubmed
22162750
uniprot
proteins
pubmed
22484091
uniprot
proteins
pubmed
34818527
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000305|PubMed:34818527}; Lipid-anchor {ECO:0000305|PubMed:18190528}. Note=During nuclear envelope repair, localizes at rupture sites where it is recruited by the CHMP7/ESCRT-III axis. {ECO:0000269|PubMed:34818527}.
uniprot
proteins