RHOC
entrez
389
canonical
uniprot
P08134
canonical
ensembl
ENSG00000155366
resolver
ensp
ENSP00000285735
resolver
ensp
ENSP00000345236
resolver
ensp
ENSP00000358646
resolver
ensp
ENSP00000358647
resolver
ensp
ENSP00000358651
resolver
ensp
ENSP00000358652
resolver
ensp
ENSP00000358656
resolver
ensp
ENSP00000555263
resolver
ensp
ENSP00000555264
resolver
ensp
ENSP00000555265
resolver
ensp
ENSP00000555266
resolver
ensp
ENSP00000555267
resolver
ensp
ENSP00000555268
resolver
ensp
ENSP00000555269
resolver
ensp
ENSP00000555270
resolver
ensp
ENSP00000555271
resolver
ensp
ENSP00000555272
resolver
ensp
ENSP00000555273
resolver
ensp
ENSP00000590802
resolver
ensp
ENSP00000590803
resolver
ensp
ENSP00000590804
resolver
ensp
ENSP00000590805
resolver
ensp
ENSP00000590806
resolver
ensp
ENSP00000590807
resolver
ensp
ENSP00000590808
resolver
ensp
ENSP00000620231
resolver
ensp
ENSP00000620232
resolver
ensp
ENSP00000620235
resolver
ensp
ENSP00000620236
resolver
ensp
ENSP00000620237
resolver
ensp
ENSP00000620239
resolver
ensp
ENSP00000620240
resolver
ensp
ENSP00000620241
resolver
ensp
ENSP00000620242
resolver
ensp
ENSP00000620243
resolver
ensp
ENSP00000620244
resolver
ensp
ENSP00000620245
resolver
ensp
ENSP00000620246
resolver
ensp
ENSP00000620247
resolver
ensp
ENSP00000620248
resolver
ensp
ENSP00000620249
resolver
ensp
ENSP00000620250
resolver
ensp
ENSP00000620251
resolver
enst
ENST00000285735
resolver
enst
ENST00000339083
resolver
enst
ENST00000369632
resolver
enst
ENST00000369633
resolver
enst
ENST00000369637
resolver
enst
ENST00000369638
resolver
enst
ENST00000369642
resolver
enst
ENST00000885204
resolver
enst
ENST00000885205
resolver
enst
ENST00000885206
resolver
enst
ENST00000885207
resolver
enst
ENST00000885208
resolver
enst
ENST00000885209
resolver
enst
ENST00000885210
resolver
enst
ENST00000885211
resolver
enst
ENST00000885212
resolver
enst
ENST00000885213
resolver
enst
ENST00000885214
resolver
enst
ENST00000920743
resolver
enst
ENST00000920744
resolver
enst
ENST00000920745
resolver
enst
ENST00000920746
resolver
enst
ENST00000920747
resolver
enst
ENST00000920748
resolver
enst
ENST00000920749
resolver
enst
ENST00000950172
resolver
enst
ENST00000950173
resolver
enst
ENST00000950176
resolver
enst
ENST00000950177
resolver
enst
ENST00000950178
resolver
enst
ENST00000950180
resolver
enst
ENST00000950181
resolver
enst
ENST00000950182
resolver
enst
ENST00000950183
resolver
enst
ENST00000950184
resolver
enst
ENST00000950185
resolver
enst
ENST00000950186
resolver
enst
ENST00000950187
resolver
enst
ENST00000950188
resolver
enst
ENST00000950189
resolver
enst
ENST00000950190
resolver
enst
ENST00000950191
resolver
enst
ENST00000950192
resolver
genesymbol
RHOC
resolver
genesymbol_syn
ARH9
resolver
genesymbol_syn
ARHC
resolver
hgnc
HGNC:669
resolver
uniprot
A0A024R0C8
resolver
uniprot
A0A024R0I3
resolver
uniprot
B3KSW1
resolver
uniprot
Q6ICN3
resolver
uniprot_entry
A0A024R0C8_HUMAN
resolver
uniprot_entry
RHOC_HUMAN
resolver
uniprot_sec
A0A024R0I3
resolver
uniprot_sec
B3KSW1
resolver
uniprot_sec
Q6ICN3
resolver
amino_acid_sequence
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGCPIL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:20974804}.
uniprot
proteins
mass_dalton
22006
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly. {ECO:0000269|PubMed:24141704}.; PTM: (Microbial infection) Glucosylated at Thr-37 by C.difficile toxins TcdA and TcdB in the colonic epithelium (PubMed:24905543). Monoglucosylation completely prevents the recognition of the downstream effector, blocking the GTPases in their inactive form, leading to actin cytoskeleton disruption (PubMed:24905543). {ECO:0000269|PubMed:24905543}.
uniprot
proteins
protein_family
Rho family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11546812
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15864301
uniprot
proteins
pubmed
16236794
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17497936
uniprot
proteins
pubmed
20400958
uniprot
proteins
pubmed
20974804
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24141704
uniprot
proteins
pubmed
24905543
uniprot
proteins
pubmed
27807006
uniprot
proteins
pubmed
3283705
uniprot
proteins
pubmed
8816443
uniprot
proteins
sequence_length
193
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cleavage furrow {ECO:0000269|PubMed:16236794}. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
uniprot
proteins