Nsd2
entrez
107823
canonical
uniprot
Q8BVE8
canonical
ensembl
ENSMUSG00000057406
resolver
ensp
ENSMUSP00000058940
resolver
ensp
ENSMUSP00000067205
resolver
ensp
ENSMUSP00000075210
resolver
ensp
ENSMUSP00000110041
resolver
ensp
ENSMUSP00000122310
resolver
ensp
ENSMUSP00000123460
resolver
ensp
ENSMUSP00000234829
resolver
ensp
ENSMUSP00000234830
resolver
ensp
ENSMUSP00000332812
resolver
enst
ENSMUST00000114399
resolver
enst
ENSMUST00000137191
resolver
enst
ENSMUST00000139845
resolver
genesymbol
Nsd2
resolver
genesymbol_syn
Kiaa1090
resolver
genesymbol_syn
Whsc1
resolver
uniprot
B3VCH6
resolver
uniprot
D3Z3E0
resolver
uniprot
Q6ZPY1
resolver
uniprot
Q7TSF5
resolver
uniprot
Q811F0
resolver
uniprot
Q8BJU7
resolver
uniprot_entry
D3Z3E0_MOUSE
resolver
uniprot_entry
NSD2_MOUSE
resolver
uniprot_entry
Q8BJU7_MOUSE
resolver
uniprot_sec
B3VCH6
resolver
uniprot_sec
Q6ZPY1
resolver
uniprot_sec
Q7TSF5
resolver
uniprot_sec
Q811F0
resolver
amino_acid_sequence
MEFSIRKSPLSVQKVVKCMKMKQTPEILGSANGKTQNCEVNHECSVFLSKAQLSNSLQEGVMQKFNGHDALPFLPAEKLKDLTSCVFNGEPGAHDTKLCFEAQEVKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDGAADVSQSEENEQKSDNKTRRNRKRSIKYDSLLEQGLVEAALVSKISSPADKKIPVKKESCPNTGRDRDLLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRAQWEMGIVQAEEAASMSIEERKAKFTFLYVGDQLHLNPQVAKEAGIVTEPLGEMVDSSGASEEAAVDPGSVREEDIPTKRRRRTKRSSSAENQEGDPGTDKSTPPKMAEAEPKRGVGSPAGRKKSTGSAPRSRKGDSAAQFLVFCQKHRDEVVAEHPDASGEEIEELLGSQWSMLNEKQKARYNTKFSLMISAQSEEDSGNGNGKKRSHTKRADDPAEDVDVEDAPRKRLRADKHSLRKRETITDKTARTSSYKAIEAASSLKSQAATKNLSDACKPLKKRNRASATASSALGFNKSSSPSASLTEHEVSDSPGDEPSESPYESADETQTEASVSSKKSERGMAAKKEYVCQLCEKTGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCTECASGIHSCFVCKESKMEVKRCVVNQCGKFYHEACVKKYPLTVFESRGFRCPLHSCMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTARKGKRHHTHVNVSWCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFNEVKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHDLRADSSSSTKTEKPFPESLKSKGKRKKRRCWRRVTDGK
uniprot
proteins
ec_number
2.1.1.357
uniprot
proteins
function
FUNCTION: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19483677, PubMed:31636135, PubMed:32862441). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:19483677). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (By similarity). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (PubMed:19483677). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:19483677, PubMed:23241889, PubMed:31636135, PubMed:32862441). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (PubMed:19483677). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (PubMed:19483677). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (By similarity). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (PubMed:31636135). During B-cell development, required for the generation of the B1 lineage (PubMed:32862441). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (PubMed:32862441). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (PubMed:23241889). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (PubMed:23241889). {ECO:0000250|UniProtKB:O96028, ECO:0000269|PubMed:19483677, ECO:0000269|PubMed:23241889, ECO:0000269|PubMed:31636135, ECO:0000269|PubMed:32862441}.; FUNCTION: [Isoform RE-IIBP]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (By similarity). Mono-, di- and tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2, H3K27me3) (PubMed:18172012). Methylation of histone H3 at 'Lys-27' is controversial (By similarity). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:18172012). {ECO:0000250|UniProtKB:O96028, ECO:0000269|PubMed:18172012}.
uniprot
proteins
mass_dalton
152253
uniprot
proteins
mutagenesis
MUTAGEN 1117; /note="F->A: Reduction in class switch recombination of the immunoglobulin heavy chain in B cells."; /evidence="ECO:0000269|PubMed:23241889"; MUTAGEN 1138; /note="R->A: No methyltransferase activity."; /evidence="ECO:0000269|PubMed:18172012"; MUTAGEN 1142; /note="H->G: No methyltransferase activity."; /evidence="ECO:0000269|PubMed:19483677"; MUTAGEN 1144; /note="C->A: No methyltransferase activity."; /evidence="ECO:0000269|PubMed:18172012
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
protein_family
SET2 subfamily
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18172012
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19483677
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23241889
uniprot
proteins
pubmed
31636135
uniprot
proteins
pubmed
32862441
uniprot
proteins
pubmed
9618163
uniprot
proteins
sequence_length
1365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:19483677}. Chromosome {ECO:0000269|PubMed:19483677, ECO:0000269|PubMed:23241889}. Note=In embryonic stem (ES) cells, localizes to small foci, probably corresponding to euchromatin (PubMed:19483677). In B-cells, localizes to Ig heavy chain switch region during class switch recombination (PubMed:23241889). {ECO:0000269|PubMed:19483677, ECO:0000269|PubMed:23241889}.
uniprot
proteins