Pde3a
entrez
50678
canonical
uniprot
Q62865
canonical
ensembl
ENSRNOG00000025042
resolver
ensembl
ENSRNOG00055009149
resolver
ensembl
ENSRNOG00060007660
resolver
ensembl
ENSRNOG00065011553
resolver
ensp
ENSRNOP00000032282
resolver
ensp
ENSRNOP00055012404
resolver
ensp
ENSRNOP00060009597
resolver
ensp
ENSRNOP00065014358
resolver
enst
ENSRNOT00000032843
resolver
enst
ENSRNOT00055015488
resolver
enst
ENSRNOT00060012660
resolver
enst
ENSRNOT00065018786
resolver
genesymbol
Pde3a
resolver
uniprot_entry
PDE3A_RAT
resolver
amino_acid_sequence
MAVRGEAAQDWAKPGLRGPSPAPVARGDHRCRGGSPSSPRGSGCCWRALALQPLRRSPQLSSALCAGSLSVLLALLVRLVGGEVGGELESSQEAAAEEEEEEGARGGVFPGPRGGAPGGGAQLSPWLQPAALLFSLLCAFFWMGLCLLRAGVRLPLAVALLAACCAGEALVQLSLGVGDGRLLSLPAAGVLLSCLGGATWLVLRLRLGVLMVALTSALRTVALVSLERFKVAWRPYLAYLAAVLGLLLARYAEQLLPQCSGPAPPRERFGSQSSARTKEEIPGWKRRRRSSSVVAGEMSGCGGKSHRRTSLPCIPREQLMGHSEWDHKRGSRGSQSGTSVTVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPTVTFSENYTCSDSEEGLEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSASIKPHEAPSPSAVNPDSWNAPVLMTLTKSRSFTSSYAVSAANHVKAKKQNRPGGLDKISPVPSPSSSPPQGSPTSSPVSGIASVQFPESPEVTTKRGPGSHRALTYTQSAPDLSPQIPPSPVICSSCGRPYSQGNPADGPSERSGPAMQKPNRTDDTSQVTSDYETNNNSDSSDILQNDEEAECQREPLRKASACGTYTPQTMIFLDKPILAPEPLVMDNLDSIMDQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPVREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLPSVIGDHGSASDSDSDSGFTHGHMGYVFSKAYHVPDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNAKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKDLHLRWTEGIASEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCHSYDSAGLMPGKWVDDSDDSGDTDDPEEEEEEAETPHEEETCENSEAPRKKSFKRRRIYCQITQHLLQNHMMWKKVIEEEQCLSGTENQAPDQAPLQHSSEQIQAIKEEEEEKGKPRAEETLAPQPDL
uniprot
proteins
ec_number
3.1.4.17
uniprot
proteins
function
FUNCTION: Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Also has activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling. {ECO:0000250|UniProtKB:Q14432}.
uniprot
proteins
mass_dalton
124301
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE3 subfamily
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9631240
uniprot
proteins
sequence_length
1141
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9Z0X4}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q14432}.
uniprot
proteins
transmembrane_region
TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 157..177; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 182..202; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 229..249; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins