Cox4i1
entrez
29445
canonical
uniprot
P10888
canonical
ensembl
ENSRNOG00000017817
resolver
ensp
ENSRNOP00000082380
resolver
enst
ENSRNOT00000107199
resolver
genesymbol
Cox4i1
resolver
genesymbol_syn
Cox4
resolver
genesymbol_syn
Cox4a
resolver
uniprot_entry
COX41_RAT
resolver
amino_acid_sequence
MLATRALSLIGKRAISTSVCLRAHGSVVKSEDYALPSYVDRRDYPLPDVAHVKLLSASQKALKEKEKADWSSLSRDEKVQLYRIQFNESFAEMNKGTNEWKTVVGLAMFFIGFTALVLIWEKSYVYGPIPHTFDRDWVAMQTKRMLDMKVNPIQGFSAKWDYNKNEWKK
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}.
uniprot
proteins
mass_dalton
19515
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P00424}.
uniprot
proteins
protein_family
Cytochrome c oxidase IV family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2159010
uniprot
proteins
pubmed
2165254
uniprot
proteins
pubmed
2174541
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2541414
uniprot
proteins
pubmed
2544859
uniprot
proteins
pubmed
31511561
uniprot
proteins
pubmed
7601105
uniprot
proteins
sequence_length
169
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00423}; Single-pass membrane protein {ECO:0000250|UniProtKB:P00423}.
uniprot
proteins
transmembrane_region
TRANSMEM 99..124; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P00423
uniprot
proteins