RragB
entrez
117043
canonical
uniprot
Q63487
canonical
ensembl
ENSRNOG00000062421
resolver
ensembl
ENSRNOG00055023806
resolver
ensembl
ENSRNOG00060021689
resolver
ensembl
ENSRNOG00065011753
resolver
ensp
ENSRNOP00000004235
resolver
ensp
ENSRNOP00000066990
resolver
ensp
ENSRNOP00000077577
resolver
ensp
ENSRNOP00000108946
resolver
enst
ENSRNOT00000075249
resolver
genesymbol
RragB
resolver
genesymbol
Rragb
resolver
genesymbol_syn
RragB
resolver
uniprot
A0A8L2QXU5
resolver
uniprot
Q6AZ37
resolver
uniprot_entry
A0A8L2QXU5_RAT
resolver
uniprot_entry
RRAGB_RAT
resolver
uniprot_sec
Q6AZ37
resolver
activity_regulation
ACTIVITY REGULATION: The activation of GTP-binding proteins is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). The Ragulator complex functions as a GEF and promotes the active GTP-bound form. The GATOR1 complex functions as a GAP and stimulates RRAGB GTPase activity to turn it into its inactive GDP-bound form, preventing mTORC1 recruitment and activation. {ECO:0000250|UniProtKB:Q5VZM2}.
uniprot
proteins
amino_acid_sequence
MEESDSEKKTEKENVGPKVEPPLGEPEGSLGWAMPNAAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATILDRIHSLQINSSLSTYSLVDSVGNTKTFDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPEAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAEIIEADEVLLFERATFLVISHYQCKEQRDAHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKQCLLMR
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagB/RRAGB is in its active form when GTP-bound RagB/RRAGB forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagB/RRAGB heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. {ECO:0000250|UniProtKB:Q5VZM2}.
uniprot
proteins
mass_dalton
43191
uniprot
proteins
protein_family
GTR/RAG GTP-binding protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7499430
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5VZM2}. Lysosome membrane {ECO:0000250|UniProtKB:Q5VZM2}. Note=Recruited to the lysosome surface by the Ragulator complex. {ECO:0000250|UniProtKB:Q5VZM2}.
uniprot
proteins