Iapp
entrez
15874
canonical
uniprot
P12968
canonical
ensembl
ENSMUSG00000041681
resolver
ensp
ENSMUSP00000043956
resolver
enst
ENSMUST00000041993
resolver
genesymbol
Iapp
resolver
uniprot_entry
IAPP_MOUSE
resolver
amino_acid_sequence
MMCISKLPAVLLILSVALNHLRATPVRSGSNPQMDKRKCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTYGKRNAAGDPNRESLDFLLV
uniprot
proteins
function
FUNCTION: Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (By similarity). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes. Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (By similarity). {ECO:0000250|UniProtKB:P10997, ECO:0000250|UniProtKB:P12969}.
uniprot
proteins
mass_dalton
10022
uniprot
proteins
protein_family
Calcitonin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2666169
uniprot
proteins
pubmed
2668946
uniprot
proteins
pubmed
9278863
uniprot
proteins
sequence_length
93
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P10997}.
uniprot
proteins