HBP1
entrez
26959
canonical
uniprot
O60381
canonical
ensembl
ENSG00000105856
resolver
ensembl
ENSG00000283847
resolver
ensp
ENSP00000222574
resolver
ensp
ENSP00000418738
resolver
ensp
ENSP00000565721
resolver
ensp
ENSP00000608574
resolver
ensp
ENSP00000628519
resolver
ensp
ENSP00000678264
resolver
ensp
ENSP00000720717
resolver
genesymbol
HBP1
resolver
hgnc
HGNC:23200
resolver
uniprot
B3KVB7
resolver
uniprot
B4DJ36
resolver
uniprot
Q8TBM1
resolver
uniprot
Q8TE93
resolver
uniprot
Q96AJ2
resolver
uniprot_entry
B4DJ36_HUMAN
resolver
uniprot_entry
HBP1_HUMAN
resolver
uniprot_sec
B3KVB7
resolver
uniprot_sec
Q8TBM1
resolver
uniprot_sec
Q8TE93
resolver
uniprot_sec
Q96AJ2
resolver
amino_acid_sequence
MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSSWNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGTRLCFHKGSNKEWQDVEDFARAEGCDNEEDLQMGIHKGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEVHIGDVCLPPGHPDAINFDDSGVFDTFKSYDFTPMDSSAVYVLSSMARQRRASLSCGGPGGQDFARSGFSKNCGSPGSSQLSSNSLYAKAVKNHSSGTVSATSPNKCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEERRMYTLEAKALAEEQKRLNPDCWKRKRTNSGSQQH
uniprot
proteins
function
FUNCTION: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. {ECO:0000269|PubMed:10562551, ECO:0000269|PubMed:10958660, ECO:0000269|PubMed:11500377}.
uniprot
proteins
mass_dalton
57645
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the CTLH E3 ubiquitin-protein ligase complex, leading to subsequent proteasomal degradation. {ECO:0000269|PubMed:29911972}.
uniprot
proteins
pubmed
10562551
uniprot
proteins
pubmed
10958660
uniprot
proteins
pubmed
11500377
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29911972
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:10562551}.
uniprot
proteins