CHRDL2
entrez
25884
canonical
uniprot
Q6WN34
canonical
ensembl
ENSG00000054938
resolver
ensp
ENSP00000263671
resolver
ensp
ENSP00000365510
resolver
genesymbol
CHRDL2
resolver
genesymbol_syn
BNF1
resolver
genesymbol_syn
CHL2
resolver
hgnc
HGNC:24168
resolver
uniprot
A5PKU9
resolver
uniprot
Q6WN30
resolver
uniprot
Q6WN31
resolver
uniprot
Q6WN32
resolver
uniprot
Q7Z5J3
resolver
uniprot_entry
CRDL2_HUMAN
resolver
uniprot_sec
A5PKU9
resolver
uniprot_sec
Q6WN30
resolver
uniprot_sec
Q6WN31
resolver
uniprot_sec
Q6WN32
resolver
uniprot_sec
Q7Z5J3
resolver
amino_acid_sequence
MVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLRCTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQHGEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASEQSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTVKIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPCRHPEKVAGKCCKICPEDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEASDLVEIYLWKLVKGIFHLTQIKKVRKQDFQKEAQHFRLLAGPHEGHWNVFLAQTLELKVTASPDKVTKT
uniprot
proteins
function
FUNCTION: May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation. {ECO:0000250, ECO:0000269|PubMed:12853144, ECO:0000269|PubMed:15094188}.
uniprot
proteins
mass_dalton
47495
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FAM20C in the extracellular medium. {ECO:0000269|PubMed:26091039}.
uniprot
proteins
pubmed
12853144
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14660436
uniprot
proteins
pubmed
15094188
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18780401
uniprot
proteins
pubmed
26091039
uniprot
proteins
sequence_length
429
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000305}.
uniprot
proteins