CNDP1
entrez
84735
canonical
uniprot
Q96KN2
canonical
ensembl
ENSG00000150656
resolver
ensp
ENSP00000351682
resolver
enst
ENST00000358821
resolver
genesymbol
CNDP1
resolver
genesymbol_syn
CN1
resolver
genesymbol_syn
CPGL2
resolver
hgnc
HGNC:20675
resolver
uniprot
Q14D40
resolver
uniprot
Q17S05
resolver
uniprot
Q2TBG0
resolver
uniprot
Q6UWK2
resolver
uniprot
Q9BT98
resolver
uniprot_entry
CNDP1_HUMAN
resolver
uniprot_sec
Q14D40
resolver
uniprot_sec
Q17S05
resolver
uniprot_sec
Q2TBG0
resolver
uniprot_sec
Q6UWK2
resolver
uniprot_sec
Q9BT98
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cadmium ions (PubMed:12473676). Inhibited by the metal chelator 1,10-o-phenantrolin. The inhibitory concentration 50% (IC(50)) is 5 uM. {ECO:0000269|PubMed:12473676}.
uniprot
proteins
amino_acid_sequence
MDPKLGRMAASLLAVLLLLLERGMFSSPSPPPALLEKVFQYIDLHQDEFVQTLKEWVAIESDSVQPVPRFRQELFRMMAVAADTLQRLGARVASVDMGPQQLPDGQSLPIPPVILAELGSDPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVDGKLYGRGATDNKGPVLAWINAVSAFRALEQDLPVNIKFIIEGMEEAGSVALEELVEKEKDRFFSGVDYIVISDNLWISQRKPAITYGTRGNSYFMVEVKCRDQDFHSGTFGGILHEPMADLVALLGSLVDSSGHILVPGIYDEVVPLTEEEINTYKAIHLDLEEYRNSSRVEKFLFDTKEEILMHLWRYPSLSIHGIEGAFDEPGTKTVIPGRVIGKFSIRLVPHMNVSAVEKQVTRHLEDVFSKRNSSNKMVVSMTLGLHPWIANIDDTQYLAAKRAIRTVFGTEPDMIRDGSTIPIAKMFQEIVHKSVVLIPLGAVDDGEHSQNEKINRWNYIEGTKLFAAFFLEMAQLH
uniprot
proteins
ec_number
3.4.13.20
uniprot
proteins
function
FUNCTION: Catalyzes the peptide bond hydrolysis in Xaa-His dipeptides, displaying the highest activity toward carnosine (beta-alanyl-L-histidine). {ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:1903095, ECO:0000269|PubMed:24891507, ECO:0000269|PubMed:7116644}.
uniprot
proteins
mass_dalton
56692
uniprot
proteins
mutagenesis
MUTAGEN 132; /note="H->A: Loss of metallodipeptidase activity."; /evidence="ECO:0000269|PubMed:12473676"; MUTAGEN 165; /note="D->A: Loss of metallodipeptidase activity."; /evidence="ECO:0000269|PubMed:12473676"; MUTAGEN 200; /note="E->A: Loss of metallodipeptidase activity."; /evidence="ECO:0000269|PubMed:12473676
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:12473676}.
uniprot
proteins
protein_family
Peptidase M20A family
uniprot
proteins
pubmed
12473676
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16046297
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
1903095
uniprot
proteins
pubmed
24891507
uniprot
proteins
pubmed
6616870
uniprot
proteins
pubmed
7116644
uniprot
proteins
sequence_length
507
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:7116644}.
uniprot
proteins