N4BP1
entrez
9683
canonical
uniprot
O75113
canonical
ensembl
ENSG00000102921
resolver
ensp
ENSP00000262384
resolver
ensp
ENSP00000632689
resolver
enst
ENST00000262384
resolver
genesymbol
N4BP1
resolver
genesymbol_syn
KIAA0615
resolver
hgnc
HGNC:29850
resolver
uniprot
A7MD49
resolver
uniprot
Q2YDX1
resolver
uniprot_entry
N4BP1_HUMAN
resolver
uniprot_sec
A7MD49
resolver
uniprot_sec
Q2YDX1
resolver
activity_regulation
ACTIVITY REGULATION: Proteolytic cleavage by CASP8 or MALT1 leads to its inactivation. {ECO:0000269|PubMed:31133753}.
uniprot
proteins
amino_acid_sequence
MAARAVLDEFTAPAEKAELLEQSRGRIEGLFGVSLAVLGALGAEEPLPARIWLQLCGAQEAVHSAKEYIKGICEPELEERECYPKDMHCIFVGAESLFLKSLIQDTCADLCILDIGLLGIRGSAEAVVMARSHIQQFVKLFENKENLPSSQKESEVKREFKQFVEAHADNYTMDLLILPTSLKKELLTLTQGEENLFETGDDEVIEMRDSQQTEFTQNAATGLNISRDETVLQEEARNKAGTPVSELTKQMDTVLSSSPDVLFDPINGLTPDEEALSNERICQKRRFSDSEERHTKKQFSLENVQEGEILHDAKTLAGNVIADLSDSSADSENLSPDIKETTEEMEYNILVNFFKTMGYSQEIVEKVIKVYGPSTEPLLLLEEIEKENKRFQEDREFSAGTVYPETNKTKNKGVYSSTNELTTDSTPKKTQAHTQQNMVEKFSQLPFKVEAKPCTSNCRINTFRTVPIEQKHEVWGSNQNYICNTDPETDGLSPSVASPSPKEVNFVSRGASSHQPRVPLFPENGLHQQPEPLLPNNMKSACEKRLGCCSSPHSKPNCSTLSPPMPLPQLLPSVTDARSAGPSDHIDSSVTGVQRFRDTLKIPYKLELKNEPGRTDLKHIVIDGSNVAITHGLKKFFSCRGIAIAVEYFWKLGNRNITVFVPQWRTRRDPNVTEQHFLTQLQELGILSLTPARMVFGERIASHDDRFLLHLADKTGGIIVTNDNFREFVNESVSWREIITKRLLQYTFVGDIFMVPDDPLGRSGPRLEEFLQKEVCLRDMQPLLSALPNVGMFDPSFRVPGTQAASTSHQPPTRIQGAPSSHWLPQQPHFPLLPALPSLQQNLPMPAQRSSAETNELREALLKIFPDSEQRLKIDQILVAHPYMKDLNALSAMVLD
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity (PubMed:31133753). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). {ECO:0000250|UniProtKB:Q6A037, ECO:0000269|PubMed:31133753}.
uniprot
proteins
mass_dalton
100379
uniprot
proteins
mutagenesis
MUTAGEN 509; /note="R->A: Abolished cleavage by MALT1."; /evidence="ECO:0000269|PubMed:31133753"; MUTAGEN 623; /note="D->N: Abolished ability to degrade HIV-1 mRNAs."; /evidence="ECO:0000269|PubMed:31133753"; MUTAGEN 866; /note="P->A: Abolished ability to interact with ubiquitin."; /evidence="ECO:0000269|PubMed:31319543
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation. Mainly cleaved at Asp-490 by CASP8 (By similarity). Cleaved by caspase-like protein MALT1 in T-cells following TCR-mediated activation, leading to its inactivation and subsequent viral reactivation during HIV-1 infection (PubMed:31133753). {ECO:0000250|UniProtKB:Q6A037, ECO:0000269|PubMed:31133753}.; PTM: Mono- and polyubiquitinated on the CoCUN region (PubMed:31319543). Monoubiquitinated by NEDD4 (By similarity). Polyubiquitinated, leading to its degradation by the proteasome (By similarity). Sumoylated with SUMO1, abrogating polyubiquitination and subsequent degradation (By similarity). Desumoylated by SENP1, leading to accumulation in PML nuclear bodies (By similarity). {ECO:0000250|UniProtKB:Q6A037, ECO:0000269|PubMed:31319543}.
uniprot
proteins
protein_family
N4BP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
31133753
uniprot
proteins
pubmed
31319543
uniprot
proteins
pubmed
31795258
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
896
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6A037}. Nucleus {ECO:0000250|UniProtKB:Q6A037}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q6A037}. Nucleus, PML body {ECO:0000250|UniProtKB:Q6A037}. Note=Primarily localizes to the nucleolus. Also localizes to the PML nuclear bodies, when desumoylated. {ECO:0000250|UniProtKB:Q6A037}.
uniprot
proteins