Gdf3
entrez
14562
canonical
uniprot
Q07104
canonical
ensembl
ENSMUSG00000030117
resolver
ensp
ENSMUSP00000032211
resolver
enst
ENSMUST00000032211
resolver
genesymbol
Gdf3
resolver
genesymbol_syn
Gdf-3
resolver
genesymbol_syn
Vgr-2
resolver
uniprot
Q3TUX1
resolver
uniprot_entry
GDF3_MOUSE
resolver
uniprot_sec
Q3TUX1
resolver
amino_acid_sequence
MQPYQRLLALGFLLLTLPWGQTSEFQDSDLLQFLGLEKAPSPHRFQPVPRVLRKIIRAREAAAASGASQDLCYVKELGVRGNLLQLLPDQGFFLNTQKPFQDGSCLQKVLYFNLSAIKEKAKLTMAQLTLDLGPRSYYNLRPELVVALSVVQDRGVWGRSHPKVGRLLFLRSVPGPQGQLQFNLQGALKDWSSNRLKNLDLHLEILVKEDRYSRVTVQPENPCDRLLRSLHASLLVVTLNPKHCHPSSRKRRAAISVPKGFCRNFCHRHQLFINFQDLGWHKWVIAPKGFMANYCHGECPFSMTTYLNSSNYAFMQALMHMADPKVPKAVCVPTKLSPISMLYQDSDKNVILRHYEDMVVDECGCG
uniprot
proteins
function
FUNCTION: Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor CRIPTO (PubMed:16368929, PubMed:17936261). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and CRIPTO. {ECO:0000269|PubMed:16368929, ECO:0000269|PubMed:17936261, ECO:0000269|PubMed:18480259}.
uniprot
proteins
mass_dalton
41586
uniprot
proteins
post_translational_modification
PTM: Synthesized as large precursor molecule that undergo proteolytic cleavage, releasing the pro-domain from the active, receptor binding, C-terminal region of the molecule. {ECO:0000250|UniProtKB:Q9NR23}.
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
11396990
uniprot
proteins
pubmed
1480182
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16368929
uniprot
proteins
pubmed
17936261
uniprot
proteins
pubmed
18480259
uniprot
proteins
pubmed
8429021
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9NR23}. Cytoplasm {ECO:0000250|UniProtKB:Q9NR23}. Note=Mainly accumulated in the cytoplasm. {ECO:0000250|UniProtKB:Q9NR23}.
uniprot
proteins