GAL3ST3
entrez
89792
canonical
uniprot
Q96A11
canonical
ensembl
ENSG00000175229
resolver
ensp
ENSP00000308591
resolver
ensp
ENSP00000434829
resolver
ensp
ENSP00000552309
resolver
ensp
ENSP00000552310
resolver
ensp
ENSP00000593316
resolver
ensp
ENSP00000615107
resolver
enst
ENST00000312006
resolver
enst
ENST00000527878
resolver
enst
ENST00000882250
resolver
enst
ENST00000882251
resolver
enst
ENST00000923257
resolver
enst
ENST00000945048
resolver
genesymbol
GAL3ST3
resolver
hgnc
HGNC:24144
resolver
uniprot
Q14D05
resolver
uniprot_entry
G3ST3_HUMAN
resolver
uniprot_sec
Q14D05
resolver
activity_regulation
ACTIVITY REGULATION: Activated about 1.7-fold by 10 mM Mg(2+). {ECO:0000269|PubMed:11323440, ECO:0000269|PubMed:14701868}.
uniprot
proteins
amino_acid_sequence
MPPILQRLQQATKMMSRRKILLLVLGCSTVSLLIHQGAQLSWYPKLFPLSCPPLRNSPPRPKHMTVAFLKTHKTAGTTVQNILFRFAERHNLTVALPHPSCEHQFCYPRNFSAHFVHPATRPPHVLASHLRFDRAELERLMPPSTVYVTILREPAAMFESLFSYYNQYCPAFRRVPNASLEAFLRAPEAYYRAGEHFAMFAHNTLAYDLGGDNERSPRDDAAYLAGLIRQVEEVFSLVMIAEYFDESLVLLRRLLAWDLDDVLYAKLNARAASSRLAAIPAALARAARTWNALDAGLYDHFNATFWRHVARAGRACVEREARELREARQRLLRRCFGDEPLLRPAAQIRTKQLQPWQPSRKVDIMGYDLPGGGAGPATEACLKLAMPEVQYSNYLLRKQKRRGGARARPEPVLDNPPPRPIRVLPRGPQGP
uniprot
proteins
ec_number
2.8.2.-
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a sulfate group from 3'-phosphoadenylyl sulfate (PAPS) to the C-3 hydroxyl group of terminal non-reducing beta-1,4-linked galactose residues in both N-glycans and O-glycans (PubMed:11323440, PubMed:11356829, PubMed:14701868). It acts efficiently on type 2 chains (Gal-beta-1,4-GlcNAc-R) found in N-glycans and core 2-branched O-glycans (Gal-beta-1,4-GlcNAc-beta-1,6(Gal-beta-1,3)GalNAc-R) (PubMed:11323440, PubMed:11356829, PubMed:14701868). In contrast, it shows poor activity on type 1 chains (Gal-beta-1,3-GlcNAc-R) and intermediate activity on core 1 structures (Gal-beta-1,3-GalNAc-R) (PubMed:11323440, PubMed:11356829). Participates in the glycoconjugates sulfation namely the 3'-sulfated Lewis X epitope (Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc), by sulfating N-acetyllactosamine (Gal-beta-1,4-GlcNAc) at the 3' position; then the resulting modification is fucosylated by FUT5 (PubMed:11356829). {ECO:0000269|PubMed:11323440, ECO:0000269|PubMed:11356829, ECO:0000269|PubMed:14701868}.
uniprot
proteins
mass_dalton
48956
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; carbohydrate sulfation. {ECO:0000269|PubMed:11323440, ECO:0000269|PubMed:11356829, ECO:0000269|PubMed:14701868}.
uniprot
proteins
protein_family
Galactose-3-O-sulfotransferase family
uniprot
proteins
pubmed
11323440
uniprot
proteins
pubmed
11356829
uniprot
proteins
pubmed
14701868
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
431
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins