ACP1
entrez
52
canonical
uniprot
P24666
canonical
ensembl
ENSG00000143727
resolver
ensp
ENSP00000272065
resolver
ensp
ENSP00000272067
resolver
ensp
ENSP00000385404
resolver
genesymbol
ACP1
resolver
hgnc
HGNC:122
resolver
uniprot
A0A140VK37
resolver
uniprot
A8K1L9
resolver
uniprot
B5MCC7
resolver
uniprot
P24667
resolver
uniprot
Q16035
resolver
uniprot
Q16036
resolver
uniprot
Q16725
resolver
uniprot
Q3KQX8
resolver
uniprot
Q53RU0
resolver
uniprot
Q59EH3
resolver
uniprot_entry
A0A140VK37_HUMAN
resolver
uniprot_entry
PPAC_HUMAN
resolver
uniprot_entry
Q59EH3_HUMAN
resolver
uniprot_sec
A8K1L9
resolver
uniprot_sec
B5MCC7
resolver
uniprot_sec
P24667
resolver
uniprot_sec
Q16035
resolver
uniprot_sec
Q16036
resolver
uniprot_sec
Q16725
resolver
uniprot_sec
Q3KQX8
resolver
uniprot_sec
Q53RU0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by sulfhydryl reagents.
uniprot
proteins
amino_acid_sequence
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
uniprot
proteins
ec_number
3.1.3.2
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2. {ECO:0000269|PubMed:10336608, ECO:0000269|PubMed:9705307}.; FUNCTION: [Isoform 3]: Does not possess phosphatase activity. {ECO:0000269|PubMed:10336608}.
uniprot
proteins
mass_dalton
18042
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="C->S: Inactive."; /evidence="ECO:0000269|PubMed:9038134"; MUTAGEN 132; /note="Y->F: Reduced phosphorylation and activity."; /evidence="ECO:0000269|PubMed:9038134"; MUTAGEN 133; /note="Y->F: Reduced phosphorylation. No effect on activity."; /evidence="ECO:0000269|PubMed:9038134
uniprot
proteins
post_translational_modification
PTM: [Isoform 2]: Phosphorylated by LCK (PubMed:10336608, PubMed:9038134). Phosphorylation at Tyr-132 increases its phosphatase activity (PubMed:9038134). {ECO:0000269|PubMed:10336608, ECO:0000269|PubMed:9038134}.; PTM: [Isoform 3]: Not phosphorylated. {ECO:0000269|PubMed:10336608}.
uniprot
proteins
protein_family
Low molecular weight phosphotyrosine protein phosphatase family
uniprot
proteins
pubmed
10336608
uniprot
proteins
pubmed
11971983
uniprot
proteins
pubmed
12167657
uniprot
proteins
pubmed
1304913
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
1587862
uniprot
proteins
pubmed
1627603
uniprot
proteins
pubmed
16344560
uniprot
proteins
pubmed
1939112
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
8364553
uniprot
proteins
pubmed
8586411
uniprot
proteins
pubmed
9038134
uniprot
proteins
pubmed
9499402
uniprot
proteins
pubmed
9705307
uniprot
proteins
sequence_length
158
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins