Trpv6
entrez
64177
canonical
uniprot
Q91WD2
canonical
ensembl
ENSMUSG00000029868
resolver
ensp
ENSMUSP00000031902
resolver
enst
ENSMUST00000031902
resolver
genesymbol
Trpv6
resolver
uniprot_entry
TRPV6_MOUSE
resolver
amino_acid_sequence
MGPLQREDRPALGGANVAPGSSPVGVWHQPQPPKEPAFHPMGWSLPKEKGLILCLWNKFCRWFHRQESWAQSRDEQNLLQQKRIWESPLLLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQKRKHIQWTYGPLTSTLYDLTEIDSSGDDQSLLELIVTTKKREARQILDQTPVKELVSLKWKRYGRPYFCVLGAIYVLYIICFTMCCVYRPLKPRITNRTNPRDNTLMQQKLLQEAYVTPKDDLRLVGELVSIVGAVIILLVEIPDIFRLGVTRFFGQTILGGPFHVIIITYAFMVLVTMVMRLTNVDGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPDELGHFYDYPMALFSTFELFLTIIDGPANYDVDLPFMYSVTYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQVVATTVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIRRYAQAFQQQDGLYSEDLEKDSGEKLETARPFGAYLSFPTPSVSRSTSRSSTNWERLRQGALRKDLRGIINRGLEDGEGWEYQI
uniprot
proteins
function
FUNCTION: Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:12574114, PubMed:12601087, PubMed:12765696, PubMed:14736889, PubMed:15123711, PubMed:17129178). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (PubMed:17129178, PubMed:22878123). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation (PubMed:15123711). In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner (PubMed:12601087). Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114). {ECO:0000269|PubMed:12574114, ECO:0000269|PubMed:12601087, ECO:0000269|PubMed:12660155, ECO:0000269|PubMed:12765696, ECO:0000269|PubMed:14736889, ECO:0000269|PubMed:15123711, ECO:0000269|PubMed:17129178, ECO:0000269|PubMed:22878123}.
uniprot
proteins
mass_dalton
87387
uniprot
proteins
mutagenesis
MUTAGEN 577; /note="L->C: Abolishes channel activity."; /evidence="ECO:0000269|PubMed:14736889"; MUTAGEN 581; /note="D->A: Abolishes binding of Mg(2+) and increases pore diameter. Impairs intestinal Ca(2+) uptake."; /evidence="ECO:0000269|PubMed:12601087, ECO:0000269|PubMed:14736889, ECO:0000269|PubMed:22878123"; MUTAGEN 581; /note="D->C: Abolishes channel activity."; /evidence="ECO:0000269|PubMed:12601087, ECO:0000269|PubMed:14736889"; MUTAGEN 581; /note="D->G: Increases pore diameter."; /evidence="ECO:0000269|PubMed:12601087, ECO:0000269|PubMed:14736889"; MUTAGEN 586; /note="Y->C: Abolishes channel activity."; /evidence="ECO:0000269|PubMed:14736889"; MUTAGEN 639; /note="T->A: Abolishes plasma membrane localization and channel activity."; /evidence="ECO:0000269|PubMed:12660155
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:12574114, ECO:0000269|PubMed:12765696, ECO:0000269|PubMed:17129178}.; PTM: Phosphorylation at Tyr-201 and Tyr-202 by SRC leads to an increased calcium influx through the channel. Probably dephosphorylated at these sites by PTPN1 (By similarity). {ECO:0000250|UniProtKB:Q9H1D0, ECO:0000250|UniProtKB:Q9R186}.
uniprot
proteins
protein_family
TRPV6 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
protein_family
TrpV subfamily
uniprot
proteins
pubmed
12574114
uniprot
proteins
pubmed
12601087
uniprot
proteins
pubmed
12660155
uniprot
proteins
pubmed
12765696
uniprot
proteins
pubmed
14736889
uniprot
proteins
pubmed
15123711
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16380433
uniprot
proteins
pubmed
17129178
uniprot
proteins
pubmed
18232717
uniprot
proteins
pubmed
20399919
uniprot
proteins
pubmed
22878123
uniprot
proteins
pubmed
23612980
uniprot
proteins
sequence_length
767
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12574114, ECO:0000269|PubMed:12601087, ECO:0000269|PubMed:12660155, ECO:0000269|PubMed:12765696, ECO:0000269|PubMed:14736889}; Multi-pass membrane protein {ECO:0000269|PubMed:12660155}.
uniprot
proteins
transmembrane_region
TRANSMEM 367..387; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9R186"; TRANSMEM 425..447; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9R186"; TRANSMEM 463..482; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9R186"; TRANSMEM 489..508; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9R186"; TRANSMEM 529..551; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9R186"; TRANSMEM 596..616; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9R186
uniprot
proteins