Il2
entrez
116562
canonical
uniprot
P17108
canonical
ensembl
ENSRNOG00000017348
resolver
ensembl
ENSRNOG00055002201
resolver
ensembl
ENSRNOG00060008511
resolver
ensembl
ENSRNOG00065008697
resolver
ensp
ENSRNOP00000023327
resolver
ensp
ENSRNOP00055002600
resolver
ensp
ENSRNOP00060010897
resolver
ensp
ENSRNOP00065010283
resolver
enst
ENSRNOT00000023327
resolver
enst
ENSRNOT00055003491
resolver
enst
ENSRNOT00060014201
resolver
enst
ENSRNOT00065013834
resolver
genesymbol
Il2
resolver
genesymbol_syn
Il-2
resolver
uniprot_entry
IL2_RAT
resolver
amino_acid_sequence
MYSMQLASCVALTLVLLVNSAPTSSPAKETQQHLEQLLLDLQVLLRGIDNYKNLKLPMMLTFKFYLPKQATELKHLQCLENELGALQRVLDLTQSKSFHLEDAGNFISNIRVTVVKLKGSENKFECQFDDEPATVVEFLRRWIAICQSIISTMTQ
uniprot
proteins
function
FUNCTION: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells. {ECO:0000250|UniProtKB:P60568}.
uniprot
proteins
mass_dalton
17633
uniprot
proteins
protein_family
IL-2 family
uniprot
proteins
pubmed
2788130
uniprot
proteins
sequence_length
155
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins