DCTN2
entrez
10540
canonical
uniprot
Q13561
canonical
ensembl
ENSG00000175203
resolver
ensp
ENSP00000408910
resolver
ensp
ENSP00000439376
resolver
ensp
ENSP00000446964
resolver
ensp
ENSP00000447824
resolver
ensp
ENSP00000504380
resolver
enst
ENST00000678653
resolver
genesymbol
DCTN2
resolver
genesymbol
HEL-S-77
resolver
genesymbol_syn
DCTN50
resolver
hgnc
HGNC:2712
resolver
uniprot
A0A384MDU9
resolver
uniprot
A0A7I2V566
resolver
uniprot
A8K8J9
resolver
uniprot
B2RBK5
resolver
uniprot
B3KTX4
resolver
uniprot
Q86YN2
resolver
uniprot
Q9BW17
resolver
uniprot
V9HW58
resolver
uniprot_entry
A0A384MDU9_HUMAN
resolver
uniprot_entry
A0A7I2V566_HUMAN
resolver
uniprot_entry
A8K8J9_HUMAN
resolver
uniprot_entry
B3KTX4_HUMAN
resolver
uniprot_entry
DCTN2_HUMAN
resolver
uniprot_entry
V9HW58_HUMAN
resolver
uniprot_sec
B2RBK5
resolver
uniprot_sec
Q86YN2
resolver
uniprot_sec
Q9BW17
resolver
amino_acid_sequence
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVLLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGGSGGKTTGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELETAVRCDQDAQNPLSAGLQGACLMETVELLQAKVSALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKVHQLYETIQRWSPIASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIANSLKDNTTLLTQVQTTMRENLATVEGNFASIDERMKKLGK
uniprot
proteins
function
FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}.
uniprot
proteins
mass_dalton
44231
uniprot
proteins
protein_family
Dynactin subunit 2 family
uniprot
proteins
pubmed
10226031
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20682791
uniprot
proteins
pubmed
20978158
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8647893
uniprot
proteins
sequence_length
401
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:8647893}. Membrane {ECO:0000269|PubMed:8647893}; Peripheral membrane protein {ECO:0000269|PubMed:8647893}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0A5G2QD80}.
uniprot
proteins