Trim8
entrez
93679
canonical
uniprot
Q99PJ2
canonical
ensembl
ENSMUSG00000025034
resolver
ensp
ENSMUSP00000026008
resolver
enst
ENSMUST00000026008
resolver
genesymbol
Trim8
resolver
genesymbol_syn
Gerp
resolver
genesymbol_syn
Rnf27
resolver
uniprot
Q3U2G3
resolver
uniprot
Q8C508
resolver
uniprot
Q8C700
resolver
uniprot
Q8CGI2
resolver
uniprot
Q99PQ4
resolver
uniprot_entry
TRIM8_MOUSE
resolver
uniprot_sec
Q3U2G3
resolver
uniprot_sec
Q8C508
resolver
uniprot_sec
Q8C700
resolver
uniprot_sec
Q8CGI2
resolver
uniprot_sec
Q99PQ4
resolver
amino_acid_sequence
MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAYNQKPGLEKNLKLTNIVEKFNALHVEKPPTALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGHSVCDVEIRRNEIRKMLMKQQERLEEREQDIEDQLYKLESDKRLVEEKVSQLKEEVRLQYEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQRLFDKTEDVGFMKNTKSVKILMDRTQTCTGSSLSPPKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTPVPFLQSVPLYPCGVNSSGAEKRKHSTAFPEASFLETSSGPVGGQYGAAGTASSEGQSGQPLGPCSSTQHLVALPGGTQPVHSSPVFPPSQYPNGSTTQQPMLPQYGGRKILVCSVDNCYCSSVANHGGHQPYPRSGHFPWTVPSQEYSHPLPPTPSVPQSLPGLAVRDWLDASQQPGHQDFYRVYGQPSTKHYVTS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response (PubMed:28747347, PubMed:31360105). Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 (PubMed:12163497). Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B (By similarity). Also modulates STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus (By similarity). Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction (PubMed:28747347). {ECO:0000250|UniProtKB:Q9BZR9, ECO:0000269|PubMed:12163497, ECO:0000269|PubMed:28747347, ECO:0000269|PubMed:31360105}.
uniprot
proteins
mass_dalton
61602
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11118312
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
12163497
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21689689
uniprot
proteins
pubmed
27995356
uniprot
proteins
pubmed
28747347
uniprot
proteins
pubmed
31360105
uniprot
proteins
sequence_length
551
uniprot
proteins