SLC22A17
entrez
51310
canonical
uniprot
Q8WUG5
canonical
ensembl
ENSG00000092096
resolver
ensp
ENSP00000346824
resolver
ensp
ENSP00000380437
resolver
genesymbol
SLC22A17
resolver
genesymbol_syn
BOCT
resolver
genesymbol_syn
BOIT
resolver
hgnc
HGNC:23095
resolver
uniprot
A0A1C7CYV9
resolver
uniprot
A4UA13
resolver
uniprot
A8MUT0
resolver
uniprot
Q2TAB0
resolver
uniprot
Q5BKY8
resolver
uniprot
Q86U04
resolver
uniprot
Q9H1D3
resolver
uniprot
Q9NQD5
resolver
uniprot_entry
S22AH_HUMAN
resolver
uniprot_sec
A0A1C7CYV9
resolver
uniprot_sec
A4UA13
resolver
uniprot_sec
A8MUT0
resolver
uniprot_sec
Q2TAB0
resolver
uniprot_sec
Q5BKY8
resolver
uniprot_sec
Q86U04
resolver
uniprot_sec
Q9H1D3
resolver
uniprot_sec
Q9NQD5
resolver
amino_acid_sequence
MAPRVATGTPEPNGGGGGKIDNTVEITPTSNGQVGTLGDAVPTEQLQGEREREREGEGDAGGDGLGSSLSLAVPPGPLSFEALLAQVGALGGGQQLQLGLCCLPVLFVALGMASDPIFTLAPPLHCHYGAFPPNASGWEQPPNASGVSVASAALAASAASRVATSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDCEHPIFPTVWAQQGNPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPTRCDHVPLLATPNPAL
uniprot
proteins
function
FUNCTION: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
68619
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16377569
uniprot
proteins
pubmed
17253959
uniprot
proteins
pubmed
19229297
uniprot
proteins
sequence_length
649
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17253959}; Multi-pass membrane protein {ECO:0000269|PubMed:17253959}. Vacuole membrane {ECO:0000269|PubMed:17253959}; Multi-pass membrane protein {ECO:0000269|PubMed:17253959}. Note=Upon LCN2-binding, it is internalized.
uniprot
proteins
transmembrane_region
TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 240..260; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 300..320; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 330..350; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 414..433; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 448..468; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 477..497; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 526..546; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 557..577; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 584..604; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins