Rabggtb
entrez
19352
canonical
uniprot
P53612
canonical
ensembl
ENSMUSG00000038975
resolver
ensp
ENSMUSP00000087396
resolver
ensp
ENSMUSP00000129481
resolver
ensp
ENSMUSP00000284481
resolver
enst
ENSMUST00000089950
resolver
enst
ENSMUST00000167111
resolver
genesymbol
Rabggtb
resolver
uniprot
A2RTE6
resolver
uniprot
F8WGR2
resolver
uniprot
Q3TVF4
resolver
uniprot_entry
F8WGR2_MOUSE
resolver
uniprot_entry
PGTB2_MOUSE
resolver
uniprot_entry
Q3TVF4_MOUSE
resolver
uniprot_sec
A2RTE6
resolver
activity_regulation
ACTIVITY REGULATION: The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM. {ECO:0000250|UniProtKB:P53611}.
uniprot
proteins
amino_acid_sequence
MGSLLFSWKGTQQKDVTIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGVYWGLTVMDLMGQLHRMNREEILVFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSVHVINVDKVVAYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVSPVFCMPEEVLQRVNVQPELVS
uniprot
proteins
ec_number
2.5.1.60
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A (PubMed:21520375). Catalytic subunit of the geranylgeranyl transferase type 3 (GGTase-3) complex (By similarity). The GGTase-3 complex geranylgeranylates and targets FBXL2 to the cellular membranes, where FBXL2 forms part of the E3 ubiquitin-protein ligase complex SCF(FBXL2) that mediates the degradation of membrane-anchored proteins (By similarity). The GGTase-3 complex geranylgeranylates Golgi v-SNARE protein YKT6 at 'Cys-194' and this prenylation is required for Golgi SNARE complex assembly (By similarity). {ECO:0000250|UniProtKB:P53611, ECO:0000269|PubMed:21520375}.
uniprot
proteins
mass_dalton
37803
uniprot
proteins
protein_family
Protein prenyltransferase subunit beta family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18161010
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21520375
uniprot
proteins
pubmed
7544156
uniprot
proteins
pubmed
9031634
uniprot
proteins
sequence_length
339
uniprot
proteins