GMEB1
entrez
10691
canonical
uniprot
Q9Y692
canonical
ensembl
ENSG00000162419
resolver
ensp
ENSP00000294409
resolver
ensp
ENSP00000355186
resolver
ensp
ENSP00000362922
resolver
ensp
ENSP00000523949
resolver
ensp
ENSP00000523950
resolver
ensp
ENSP00000523951
resolver
ensp
ENSP00000523956
resolver
ensp
ENSP00000523957
resolver
ensp
ENSP00000610281
resolver
ensp
ENSP00000610284
resolver
ensp
ENSP00000611644
resolver
genesymbol
GMEB1
resolver
hgnc
HGNC:4370
resolver
uniprot
B1AT47
resolver
uniprot
B1AT48
resolver
uniprot
B2RCN8
resolver
uniprot
Q9NWH1
resolver
uniprot
Q9UKD0
resolver
uniprot_entry
B1AT47_HUMAN
resolver
uniprot_entry
B2RCN8_HUMAN
resolver
uniprot_entry
GMEB1_HUMAN
resolver
uniprot_sec
B1AT48
resolver
uniprot_sec
Q9NWH1
resolver
uniprot_sec
Q9UKD0
resolver
amino_acid_sequence
MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGLFIDGHFYNRIYEAGSENNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMATEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDAAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKSQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEEKVVAEMEEHQHQVHNVEIVVLED
uniprot
proteins
function
FUNCTION: Acts as a DNA-binding transcriptional regulator involved in modulating the expression of genes responsive to glucocorticoid signaling (PubMed:12702733). Specifically binds AT-rich DNA motifs known as glucocorticoid modulatory elements (GMEs), repressing or enhancing transcription depending on cellular context (PubMed:10894151). Forms heterodimeric complexes with GMEB2, which enhances its DNA-binding specificity and transcriptional activity. This complex plays a critical role in the repression of glucocorticoid receptor (GR/NR3C1) transcriptional activity, acting as a negative modulator of glucocorticoid signaling (PubMed:10894151). Regulates dopamine-enriched midbrain genes, including tyrosine hydroxylase/TH and the dopamine transporter SLC6A3, essential for dopamine signaling (By similarity). Also binds the transferrin receptor promoter. In the cytoplasm, inhibits caspase activation and neuronal apoptosis by stabilizing CFLARL and blocking pro-caspase 8 activation (PubMed:31046799, PubMed:32514408). {ECO:0000250|UniProtKB:Q9JL60, ECO:0000269|PubMed:10894151, ECO:0000269|PubMed:12702733, ECO:0000269|PubMed:31046799, ECO:0000269|PubMed:32514408}.
uniprot
proteins
mass_dalton
62591
uniprot
proteins
pubmed
10386584
uniprot
proteins
pubmed
10523663
uniprot
proteins
pubmed
10894151
uniprot
proteins
pubmed
12702733
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
31046799
uniprot
proteins
pubmed
32514408
uniprot
proteins
sequence_length
573
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=May be also cytoplasmic.
uniprot
proteins