Slc38a9
entrez
310091
canonical
uniprot
Q3B8Q3
canonical
ensembl
ENSRNOG00000009851
resolver
ensembl
ENSRNOG00055011365
resolver
ensembl
ENSRNOG00060004297
resolver
ensembl
ENSRNOG00065020359
resolver
ensp
ENSRNOP00000099743
resolver
ensp
ENSRNOP00055015547
resolver
ensp
ENSRNOP00060005466
resolver
ensp
ENSRNOP00065027544
resolver
enst
ENSRNOT00055019275
resolver
enst
ENSRNOT00060007209
resolver
enst
ENSRNOT00065034394
resolver
genesymbol
Slc38a9
resolver
uniprot
H9BFG3
resolver
uniprot
Q561Z8
resolver
uniprot
R9PXU2
resolver
uniprot_entry
H9BFG3_RAT
resolver
uniprot_entry
S38A9_RAT
resolver
uniprot_sec
Q561Z8
resolver
uniprot_sec
R9PXU2
resolver
amino_acid_sequence
MANVDSDSRHLISEVEHEVNPGPMNIQFDSSDLRSKRPFYIEPTNIVNVNDVIQKVSDHAAAMNKRIHYYSRLTTPADKALIAPDHVVPAPEECYVYSPLGSAYKLKSYTEGYRKNTSLVTIFMIWNTMMGTSILSIPWGIKQAGFTTGMCVIVLMGLLTLYCCYRVVKSRSMIVTSDTTTWEYPDVCKHYFGSFGQWSSLLFSLVSLIGAMIVYWVLMSNFLFNTGKFIFNFIHHINDTDTVLSTNNSSPVICPSAGSGHPDNSSMIFYNSDTEVRLFERWWDKSKTVPFYLIGLLLPLLNFKSPSFFSKFNILGTVSVLYLIFIVTLKAIRLGFHLEFHWFAPTEFFVPEIRAQFPQLTGVLTLAFFIHNCIITLLKNNKNQENNVRDLCIAYMLVTLTYLYIGVLVFASFPSPPLPKDCIEQNFLDNFPSSDTLSFIARICLLFQMMTVYPLLGYLARVQLLGHIFGDIYPSIFHVLILNLIIVGAGVTMACFYPNIGGIIRYSGAACGLAFVFIYPSLIYILSQHQEERLTWPKLVFHIIIIILGLANLIAQFFM
uniprot
proteins
function
FUNCTION: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids. Acts as an arginine sensor. Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation. However, the transport mechanism is not well defined and the role of sodium is not clear. Can disassemble the lysosomal folliculin complex (LFC), and thereby triggers GAP activity of FLCN:FNIP2 toward RRAGC. Acts as an cholesterol sensor that conveys increases in lysosomal cholesterol, leading to lysosomal recruitment and activation of mTORC1 via the Rag GTPases. Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency. {ECO:0000250|UniProtKB:Q8NBW4}.
uniprot
proteins
mass_dalton
63418
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q8NBW4}.
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
protein_family
SLC38A9 subfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
559
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q8NBW4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q08BA4}. Late endosome membrane {ECO:0000250|UniProtKB:Q8NBW4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q08BA4}.
uniprot
proteins
transmembrane_region
TRANSMEM 119..139; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 146..166; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 198..224; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 282..298; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 308..332; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 355..375; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 393..413; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 436..456; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 478..498; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 506..526; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q08BA4"; TRANSMEM 539..559; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q08BA4
uniprot
proteins