Antxr1
entrez
69538
canonical
uniprot
Q9CZ52
canonical
ensembl
ENSMUSG00000033420
resolver
ensp
ENSMUSP00000045634
resolver
genesymbol
Antxr1
resolver
genesymbol_syn
Atr
resolver
genesymbol_syn
Tem8
resolver
uniprot
Q505H2
resolver
uniprot_entry
ANTR1_MOUSE
resolver
uniprot_sec
Q505H2
resolver
amino_acid_sequence
MDRAGRLGAGLRGLCVAALVLVCAGHGGRREDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHRFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENSQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFAVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLVLFLLLALALLWWFWPLCCTVIIKEVPPPPVEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNSQPAKYPLNNTYHPSSPPPAPIYTPPPPAPHCPPPAPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPSRPPPRPSV
uniprot
proteins
function
FUNCTION: Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis (PubMed:19622764). Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2. {ECO:0000250|UniProtKB:Q9H6X2, ECO:0000269|PubMed:19622764}.
uniprot
proteins
mass_dalton
62308
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q9H6X2}.; PTM: Phosphorylated upon PLAU binding. {ECO:0000250|UniProtKB:Q9H6X2}.
uniprot
proteins
protein_family
ATR family
uniprot
proteins
pubmed
11559528
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19622764
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
562
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H6X2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9H6X2}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:Q9H6X2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9H6X2}. Cell projection, filopodium membrane {ECO:0000250|UniProtKB:Q9H6X2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9H6X2}. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia. {ECO:0000250|UniProtKB:Q9H6X2}.
uniprot
proteins
transmembrane_region
TRANSMEM 320..340; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins