Aqp9
entrez
65054
canonical
uniprot
P56627
canonical
ensembl
ENSRNOG00000061883
resolver
ensp
ENSRNOP00000069377
resolver
ensp
ENSRNOP00000103858
resolver
enst
ENSRNOT00000087980
resolver
genesymbol
Aqp9
resolver
genesymbol_syn
Aqp9l
resolver
uniprot
O88815
resolver
uniprot_entry
AQP9_RAT
resolver
uniprot_sec
O88815
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is inhibited by mercury ions and phloretin. {ECO:0000269|PubMed:9733774}.
uniprot
proteins
amino_acid_sequence
MPSEKDGAKKSLMQRLALKSRIAKETLSEFLGTFIMIVLGCSSIAQAVLSRERFGGIITINIGFASAVVMALYVTFGISGGHINPAVSFAMCAFGRMEWFKFPFYVGAQFLGAFVGAATVFGIYYDGLMAFAGGKLLVVGENATAFIFATYPAPFISTPGAFVDQVVSTMFLLLIVFAMFDSRNLGVPRGLEPVVIGLLIIVLSCSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFTVGNNFWWIPVVGPMIGAFLGGLIYILFIQMHHSKLDPDMKAEPSENNLEKHELSVIM
uniprot
proteins
function
FUNCTION: Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:10205677, PubMed:9733774). AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis (By similarity). It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines (PubMed:9733774). AQP9 may also facilitate hepatic urea extrusion. Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy. Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity (PubMed:11972053). It is also permeable to H2O2 in vivo (By similarity). Could also be permeable to ammonium (PubMed:15988592). {ECO:0000250|UniProtKB:Q9JJJ3, ECO:0000269|PubMed:10205677, ECO:0000269|PubMed:11972053, ECO:0000269|PubMed:15988592, ECO:0000269|PubMed:9733774}.
uniprot
proteins
mass_dalton
31871
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
10205677
uniprot
proteins
pubmed
11972053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15988592
uniprot
proteins
pubmed
9733774
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9733774}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96PS8}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9JJJ3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96PS8}. Note=Functions at the hepatocyte basolateral membrane. {ECO:0000250|UniProtKB:Q9JJJ3}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..43; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q96PS8"; TRANSMEM 58..77; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q96PS8"; TRANSMEM 99..123; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q96PS8"; TRANSMEM 161..178; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q96PS8"; TRANSMEM 191..207; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q96PS8"; TRANSMEM 244..264; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q96PS8
uniprot
proteins