RNPS1
entrez
10921
canonical
uniprot
Q15287
canonical
ensembl
ENSG00000205937
resolver
ensp
ENSP00000315859
resolver
ensp
ENSP00000380275
resolver
ensp
ENSP00000454461
resolver
ensp
ENSP00000454513
resolver
ensp
ENSP00000456352
resolver
ensp
ENSP00000457723
resolver
ensp
ENSP00000457820
resolver
enst
ENST00000567147
resolver
genesymbol
RNPS1
resolver
genesymbol
rnps1
resolver
genesymbol_syn
LDC2
resolver
hgnc
HGNC:10080
resolver
uniprot
A8K1P0
resolver
uniprot
B4DDU8
resolver
uniprot
B4DZU7
resolver
uniprot
B7ZA17
resolver
uniprot
D3DU92
resolver
uniprot
H3BMS0
resolver
uniprot
O75308
resolver
uniprot
Q32P25
resolver
uniprot
Q8WY42
resolver
uniprot
Q9NYG3
resolver
uniprot_entry
D3DU92_HUMAN
resolver
uniprot_entry
H3BMS0_HUMAN
resolver
uniprot_entry
RNPS1_HUMAN
resolver
uniprot_sec
A8K1P0
resolver
uniprot_sec
B4DDU8
resolver
uniprot_sec
B4DZU7
resolver
uniprot_sec
B7ZA17
resolver
uniprot_sec
O75308
resolver
uniprot_sec
Q32P25
resolver
uniprot_sec
Q8WY42
resolver
uniprot_sec
Q9NYG3
resolver
amino_acid_sequence
MDLSGVKKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSPSRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMHPHLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLAPWPRPPPRRFSPPRRMLPPPPMWRRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHRSRSSSNSSR
uniprot
proteins
function
FUNCTION: Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions. {ECO:0000269|PubMed:10449421, ECO:0000269|PubMed:11546874, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:14729963, ECO:0000269|PubMed:14752011, ECO:0000269|PubMed:15684395, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:17586820, ECO:0000269|PubMed:22203037}.
uniprot
proteins
mass_dalton
34208
uniprot
proteins
mutagenesis
MUTAGEN 53; /note="S->A: Abolishes phosphorylation by CSNK2A1 and partially reduces splicing stimulation. Does not abolish interaction with CSNK2A1 and subcellular localization."; /evidence="ECO:0000269|PubMed:15684395"; MUTAGEN 53; /note="S->E: Partially reduces splicing stimulation. Does not abolish interaction with CSNK2A1 and subcellular localization."; /evidence="ECO:0000269|PubMed:15684395"; MUTAGEN 171; /note="N->R: Impairs interaction with SAP18."; /evidence="ECO:0000269|PubMed:22388736"; MUTAGEN 205; /note="Y->A: Abolishes exon-skipping."; /evidence="ECO:0000269|PubMed:14729963"; MUTAGEN 207; /note="Y->A: Abolishes exon-skipping."; /evidence="ECO:0000269|PubMed:14729963
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on one or more of the four Ser/Thr residues (Ser-43, Thr-49, Ser-52 or Ser-53). Ser-53 phosphorylation site is important for splicing and translation stimulation activity in vitro. {ECO:0000269|PubMed:15684395}.
uniprot
proteins
protein_family
Splicing factor SR family
uniprot
proteins
pubmed
10449421
uniprot
proteins
pubmed
11118221
uniprot
proteins
pubmed
11477570
uniprot
proteins
pubmed
11546874
uniprot
proteins
pubmed
12665594
uniprot
proteins
pubmed
12944400
uniprot
proteins
pubmed
14517304
uniprot
proteins
pubmed
14625303
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14729963
uniprot
proteins
pubmed
14752011
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
15684395
uniprot
proteins
pubmed
16209946
uniprot
proteins
pubmed
16314458
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17586820
uniprot
proteins
pubmed
19324961
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20966198
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22203037
uniprot
proteins
pubmed
22388736
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
8543184
uniprot
proteins
pubmed
9580558
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
uniprot
proteins