Eef1a1
entrez
171361
canonical
uniprot
P62630
canonical
ensembl
ENSRNOG00000009439
resolver
ensembl
ENSRNOG00055004783
resolver
ensembl
ENSRNOG00060021266
resolver
ensembl
ENSRNOG00065017068
resolver
ensp
ENSRNOP00000013608
resolver
ensp
ENSRNOP00055005733
resolver
ensp
ENSRNOP00060030325
resolver
ensp
ENSRNOP00065022553
resolver
enst
ENSRNOT00000013608
resolver
enst
ENSRNOT00055007614
resolver
enst
ENSRNOT00060036814
resolver
enst
ENSRNOT00065028498
resolver
genesymbol
Eef1a1
resolver
genesymbol_syn
Eef1a
resolver
uniprot
P20001
resolver
uniprot
Q5BJW8
resolver
uniprot
Q64718
resolver
uniprot
Q78ED4
resolver
uniprot_entry
EF1A1_RAT
resolver
uniprot_sec
P20001
resolver
uniprot_sec
Q5BJW8
resolver
uniprot_sec
Q64718
resolver
uniprot_sec
Q78ED4
resolver
amino_acid_sequence
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGSASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome. The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation. Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (By similarity). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:P68105}.
uniprot
proteins
mass_dalton
50114
uniprot
proteins
post_translational_modification
PTM: ISGylated. {ECO:0000250|UniProtKB:P68104}.; PTM: Phosphorylated by TXK. Phosphorylation by PASK increases translation efficiency. Phosphorylated by ROCK2. Phosphorylation by TGFBR1 inhibits translation elongation. {ECO:0000250|UniProtKB:P68104}.; PTM: Trimethylated at Lys-79 by EEF1AKMT1. Methylated at Lys-165 by EEF1AKMT3, methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation. Trimethylated at Lys-318 by EEF1AKMT2. Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs. Trimethylated at Gly-2 by METTL13. Mono- and dimethylated at Lys-55 by METTL13; dimethylated form is predominant. {ECO:0000250|UniProtKB:P68104}.; PTM: Ubiquitinated at Lys-385 by RNF14 in response to ribosome collisions (ribosome stalling), leading to its degradation by the proteasome and rescue of stalled ribosomes. {ECO:0000250|UniProtKB:P68104}.
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
EF-Tu/EF-1A subfamily
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
1542580
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1730661
uniprot
proteins
pubmed
1762922
uniprot
proteins
pubmed
31468715
uniprot
proteins
pubmed
7945283
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P68104}. Nucleus {ECO:0000250|UniProtKB:P68104}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P68104}. Cell membrane {ECO:0000250|UniProtKB:P68104}. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery. Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens. Localization at the cell membrane depends on EEF1A1 phosphorylation status and the presence of PPP1R16B. {ECO:0000250|UniProtKB:P68104}.
uniprot
proteins