IGSF8
entrez
93185
canonical
uniprot
Q969P0
canonical
ensembl
ENSG00000162729
resolver
ensp
ENSP00000316664
resolver
ensp
ENSP00000357065
resolver
ensp
ENSP00000477565
resolver
ensp
ENSP00000554044
resolver
genesymbol
IGSF8
resolver
genesymbol_syn
CD81P3
resolver
genesymbol_syn
EWI2
resolver
genesymbol_syn
KCT4
resolver
hgnc
HGNC:17813
resolver
uniprot
Q8NG09
resolver
uniprot
Q96DP4
resolver
uniprot
Q9BTG9
resolver
uniprot_entry
IGSF8_HUMAN
resolver
uniprot_sec
Q8NG09
resolver
uniprot_sec
Q96DP4
resolver
uniprot_sec
Q9BTG9
resolver
amino_acid_sequence
MGALRPTLLPPSLPLLLLLMLGMGCWAREVLVPEGPLYRVAGTAVSISCNVTGYEGPAQQNFEWFLYRPEAPDTALGIVSTKDTQFSYAVFKSRVVAGEVQVQRLQGDAVVLKIARLQAQDAGIYECHTPSTDTRYLGSYSGKVELRVLPDVLQVSAAPPGPRGRQAPTSPPRMTVHEGQELALGCLARTSTQKHTHLAVSFGRSVPEAPVGRSTLQEVVGIRSDLAVEAGAPYAERLAAGELRLGKEGTDRYRMVVGGAQAGDAGTYHCTAAEWIQDPDGSWAQIAEKRAVLAHVDVQTLSSQLAVTVGPGERRIGPGEPLELLCNVSGALPPAGRHAAYSVGWEMAPAGAPGPGRLVAQLDTEGVGSLGPGYEGRHIAMEKVASRTYRLRLEAARPGDAGTYRCLAKAYVRGSGTRLREAASARSRPLPVHVREEGVVLEAVAWLAGGTVYRGETASLLCNISVRGGPPGLRLAASWWVERPEDGELSSVPAQLVGGVGQDGVAELGVRPGGGPVSVELVGPRSHRLRLHSLGPEDEGVYHCAPSAWVQHADYSWYQAGSARSGPVTVYPYMHALDTLFVPLLVGTGVALVTGATVLGTITCCFMKRLRKR
uniprot
proteins
function
FUNCTION: Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity (PubMed:11504738, PubMed:14662754). Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities (PubMed:17785435). In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation (PubMed:22689882). Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry (PubMed:23351194). Accumulates at the presynaptic terminal, the producer cell side of the virological synapse, to prevent HIV-1 Env-mediated cell-cell fusion (PubMed:31757023). Highly expressed on malignant cells with antigen presentation defects, interacts with NK receptor KIR3DL2 to suppress NK-cell cytotoxicity (PubMed:38657602). May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. {ECO:0000269|PubMed:11504738, ECO:0000269|PubMed:12750295, ECO:0000269|PubMed:12752121, ECO:0000269|PubMed:14662754, ECO:0000269|PubMed:15070678, ECO:0000269|PubMed:17785435, ECO:0000269|PubMed:22689882, ECO:0000269|PubMed:23351194, ECO:0000269|PubMed:31757023}.
uniprot
proteins
mass_dalton
65034
uniprot
proteins
pubmed
11504738
uniprot
proteins
pubmed
12708969
uniprot
proteins
pubmed
12750295
uniprot
proteins
pubmed
12752121
uniprot
proteins
pubmed
14662754
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15070678
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17785435
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19892738
uniprot
proteins
pubmed
22689882
uniprot
proteins
pubmed
23351194
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
31757023
uniprot
proteins
pubmed
38657602
uniprot
proteins
sequence_length
613
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22689882}; Single-pass membrane protein. Note=Colocalizes with CD81 at the immune synapse. {ECO:0000269|PubMed:22689882}.
uniprot
proteins
transmembrane_region
TRANSMEM 580..600; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins