Abcc4
entrez
170924
canonical
uniprot
F1M3J4
canonical
ensembl
ENSRNOG00000010064
resolver
ensp
ENSRNOP00000033826
resolver
ensp
ENSRNOP00000076836
resolver
ensp
ENSRNOP00000089564
resolver
enst
ENSRNOT00000100006
resolver
genesymbol
Abcc4
resolver
genesymbol_syn
Mrp4
resolver
uniprot
A0A8I5YBX7
resolver
uniprot
Q6QMG6
resolver
uniprot_entry
A0A8I5YBX7_RAT
resolver
uniprot_entry
MRP4_RAT
resolver
uniprot_sec
Q6QMG6
resolver
amino_acid_sequence
MLPVHTEVKPNPLQDANLCSRLFFWWLNPLFKAGHKRRLEEDDMFSVLPEDRSKHLGEELQGYWDKEVLRAKKDARKPSLTKAIVKCYWKSYLILGIFTLIEETTRVVQPIFLGKIIDYFEKYDSDDSAALHTAYGYAAVLSLCTLILAILHHLYFYHVQCAGMRIRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIGVTILLWVEIGISCLAGLAILVILLPLQSCIGKLFSSLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLITNLRKKEISKILGSSYLRGMNMASFFIANKVILFVTFTTYVLLGNKITASHVFVAMTLYGAVRLTVTLFFPSAIERVSEAVVSVRRIKNFLLLDELPERKAQEPSDGKAIVHVQDFTAFWDKALDTPTLQGLSFTARPGELLAVVGPVGAGKSSLLSAVLGELPPTSGLVSVHGRIAYVSQQPWVFSGTVRSNILFGRKYEKERYEKVIKACALKKDFQLLEDGDRLVIGDRGARLSGGQKARVNLATAVYQDADIYLLDDPLSAVDAEVGKHLFQLCICQTLHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFGSLLKKENEEAEPSPVPGTPTLRNRTFSEASIWSQQSSRPSLKDGVPDAQDAENTQAAQPEESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNLMGQVFYVLQDWWLSHWANRQGALNDTKNANGNVTGTLDLSWYLGIYTGLTAVTVLFGIARSLLVFYVLVNASQTLHNRMFESILKAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSIIFVVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAVFVIVVAFGSLVLAKTLDAGQVGLALSYSLTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEKEAPWECRKRPPPGWPHEGVIVFDNVNFTYSLDGPLVLKHLTALIKSREKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHSDEELWKALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKKNRILIIDEATANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLREYDEPYVLLQNPESLFYKMVQQLGKGEAAALTETAKQVYFRRNYPDIAFSSPAVMSTSNGQPSALTIFETAL
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
ec_number
7.6.2.3
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells (By similarity). Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (By similarity). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (By similarity). Mediates the cotransport of bile acids with reduced glutathione (GSH) (By similarity). May contribute to hepatic, intestinal and renal excretion of steroid conjugates. Selectively transports steroid glucuronates and sulfates. Mediates the efflux of estrogens glucuronated at C-16 and C-17 positions, but has no transporter activity toward estrogens glucuronated at C-3. Has high affinity for dehydroepiandrosterone-3-sulfate and can also transport testosterone-17-sulfate, but has no transporter activity toward androsterone and etiocholanolone sulfate conjugates. Does not transport estrone 3-sulfate (By similarity). Displays low affinity and high transport velocity for folates (By similarity). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotic molecules (By similarity). Confers resistance to anticancer agents such as methotrexate (By similarity). {ECO:0000250|UniProtKB:O15439}.
uniprot
proteins
mass_dalton
148904
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; leading to substrate-selective effects on its transport activity. {ECO:0000250|UniProtKB:O15439}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCC family
uniprot
proteins
protein_family
Conjugate transporter (TC 3.A.1.208) subfamily
uniprot
proteins
pubmed
12883481
uniprot
proteins
pubmed
15047146
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12883481}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O15439}. Apical cell membrane {ECO:0000250|UniProtKB:O15439}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O15439}. Note=Its localization to the basolateral or apical membranes is tissue-dependent. {ECO:0000250|UniProtKB:O15439}.
uniprot
proteins
transmembrane_region
TRANSMEM 89..131; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 137..176; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 211..244; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 247..274; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 319..352; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 357..390; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 720..755; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 769..803; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 840..871; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 874..892; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 950..984; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 985..1014; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:O15439
uniprot
proteins