AGT
entrez
183
canonical
uniprot
P01019
canonical
ensembl
ENSG00000135744
resolver
ensp
ENSP00000355627
resolver
ensp
ENSP00000504866
resolver
ensp
ENSP00000505063
resolver
ensp
ENSP00000505963
resolver
ensp
ENSP00000505985
resolver
enst
ENST00000366667
resolver
enst
ENST00000679738
resolver
enst
ENST00000680041
resolver
enst
ENST00000681269
resolver
enst
ENST00000681514
resolver
genesymbol
AGT
resolver
genesymbol
hFLT1
resolver
genesymbol_syn
AGT
resolver
genesymbol_syn
SERPINA8
resolver
hgnc
HGNC:333
resolver
uniprot
A0A024R3V3
resolver
uniprot
A0A7P0T8D1
resolver
uniprot
B0ZBE2
resolver
uniprot
B2R5S1
resolver
uniprot
Q16358
resolver
uniprot
Q16359
resolver
uniprot
Q96F91
resolver
uniprot_entry
A0A7P0T8D1_HUMAN
resolver
uniprot_entry
ANGT_HUMAN
resolver
uniprot_entry
B0ZBE2_HUMAN
resolver
uniprot_entry
B2R5S1_HUMAN
resolver
uniprot_sec
A0A024R3V3
resolver
uniprot_sec
Q16358
resolver
uniprot_sec
Q16359
resolver
uniprot_sec
Q96F91
resolver
amino_acid_sequence
MAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGMHSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVANPLSTA
uniprot
proteins
disease_involvement
DISEASE: Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher than normal with no identifiable cause. {ECO:0000269|PubMed:1394429, ECO:0000269|PubMed:8513325}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269|PubMed:16116425}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. {ECO:0000269|PubMed:10619573, ECO:0000269|PubMed:1132082, ECO:0000269|PubMed:17138938}.; FUNCTION: [Angiotensin-2]: Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (PubMed:10619573, PubMed:17138938). Acts by binding to angiotensin receptors AGTR1 and AGTR2 (PubMed:1567413). Also binds the DEAR/FBXW7-AS1 receptor (By similarity). {ECO:0000250|UniProtKB:P01015, ECO:0000269|PubMed:10619573, ECO:0000269|PubMed:1567413, ECO:0000269|PubMed:17138938}.; FUNCTION: [Angiotensin-3]: Stimulates aldosterone release. {ECO:0000269|PubMed:1132082}.; FUNCTION: [Angiotensin 1-7]: Is a ligand for the G protein-coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity). {ECO:0000250|UniProtKB:P11859}.
uniprot
proteins
mass_dalton
52070
uniprot
proteins
post_translational_modification
PTM: Beta-decarboxylation of Asp-25 in angiotensin-2, by mononuclear leukocytes produces alanine (PubMed:17138938). The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor (PubMed:17138938). {ECO:0000269|PubMed:17138938}.; PTM: In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1 (PubMed:12045255). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (PubMed:10969042, PubMed:4322742). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4 (PubMed:10969042, PubMed:11815627). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4 (PubMed:10969042, PubMed:11815627). Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin) (PubMed:15283675). {ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:11815627, ECO:0000269|PubMed:12045255, ECO:0000269|PubMed:15283675, ECO:0000269|PubMed:4322742}.; PTM: The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin. {ECO:0000269|PubMed:20927107}.
uniprot
proteins
protein_family
Serpin family
uniprot
proteins
pubmed
10619573
uniprot
proteins
pubmed
10969042
uniprot
proteins
pubmed
1132082
uniprot
proteins
pubmed
11815627
uniprot
proteins
pubmed
12045255
uniprot
proteins
pubmed
12752436
uniprot
proteins
pubmed
1394429
uniprot
proteins
pubmed
15283675
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1567413
uniprot
proteins
pubmed
16116425
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
1692023
uniprot
proteins
pubmed
17138938
uniprot
proteins
pubmed
18793332
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
20927107
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2885106
uniprot
proteins
pubmed
2924688
uniprot
proteins
pubmed
3579322
uniprot
proteins
pubmed
3934016
uniprot
proteins
pubmed
4300938
uniprot
proteins
pubmed
4322742
uniprot
proteins
pubmed
6089875
uniprot
proteins
pubmed
7259779
uniprot
proteins
pubmed
7539791
uniprot
proteins
pubmed
7607642
uniprot
proteins
pubmed
7744780
uniprot
proteins
pubmed
8185599
uniprot
proteins
pubmed
8513325
uniprot
proteins
pubmed
8621667
uniprot
proteins
pubmed
9492317
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:4300938, ECO:0000305|PubMed:7259779, ECO:0000305|PubMed:7539791}.
uniprot
proteins