Sufu
entrez
24069
canonical
uniprot
Q9Z0P7
canonical
ensembl
ENSMUSG00000025231
resolver
ensp
ENSMUSP00000049109
resolver
ensp
ENSMUSP00000107498
resolver
genesymbol
Sufu
resolver
uniprot
Q3U0Z8
resolver
uniprot
Q8C8B4
resolver
uniprot
Q99JG0
resolver
uniprot
Q9D521
resolver
uniprot
Q9JLU1
resolver
uniprot_entry
Q3U0Z8_MOUSE
resolver
uniprot_entry
SUFU_MOUSE
resolver
uniprot_sec
Q8C8B4
resolver
uniprot_sec
Q99JG0
resolver
uniprot_sec
Q9D521
resolver
uniprot_sec
Q9JLU1
resolver
amino_acid_sequence
MAELRPSVAPGPAAPPASGPSAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDPLDYVSMYRNMGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVRTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDEEDSRSICLGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINSQRQNGLTHDRAPSRKDSLGSDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDLTSPEEFKLPKEYSWPEKKLKVSILPDVVFDSPLH
uniprot
proteins
function
FUNCTION: Negative regulator in the hedgehog/smoothened signaling pathway that acts by sequestering the GLI (GI1, GLI2 and GLI3) transcription factors in the cytoplasm (PubMed:10531011, PubMed:11960000, PubMed:16155214, PubMed:16459298, PubMed:19622347, PubMed:20360384, PubMed:20956384). When smoothened signaling is initiated, GLI transcription factors dissociate from SUFU, translocate to the nucleus and activate expression of target genes (PubMed:10531011, PubMed:11960000, PubMed:16155214, PubMed:16459298, PubMed:19622347, PubMed:20360384, PubMed:20956384). In absence of smoothened signaling, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of full-length GLI3 into transcription repressor GLI3R: SUFU participates to GLI3 processing by promoting recruitment of GSK3B to GLI3 (PubMed:10531011, PubMed:19622347, PubMed:20360384). May also act as a negative regulator of beta-catenin signaling (PubMed:11477086). Required for normal embryonic development (PubMed:16155214, PubMed:16459298). Required for the proper formation of hair follicles and the control of epidermal differentiation (PubMed:16155214, PubMed:16459298, PubMed:23034632). {ECO:0000269|PubMed:10531011, ECO:0000269|PubMed:11477086, ECO:0000269|PubMed:11960000, ECO:0000269|PubMed:16155214, ECO:0000269|PubMed:16459298, ECO:0000269|PubMed:19622347, ECO:0000269|PubMed:20360384, ECO:0000269|PubMed:20956384, ECO:0000269|PubMed:23034632}.
uniprot
proteins
mass_dalton
53957
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated at Lys-257 by the SCF(FBXL17) complex, leading to its subsequent degradation and allowing the release of GLI1 for proper hedgehog/smoothened signal transduction. Ubiquitination is impaired by phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353. {ECO:0000250|UniProtKB:Q9UMX1}.; PTM: Phosphorylation at Ser-342, Ser-346, Ser-352 and Thr-353 prevents ubiquitination by the SCF(FBXL17) complex. {ECO:0000250|UniProtKB:Q9UMX1}.
uniprot
proteins
protein_family
SUFU family
uniprot
proteins
pubmed
10531011
uniprot
proteins
pubmed
11252182
uniprot
proteins
pubmed
11477086
uniprot
proteins
pubmed
11557033
uniprot
proteins
pubmed
11960000
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16155214
uniprot
proteins
pubmed
16459298
uniprot
proteins
pubmed
19592253
uniprot
proteins
pubmed
19622347
uniprot
proteins
pubmed
20360384
uniprot
proteins
pubmed
20956384
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23034632
uniprot
proteins
pubmed
38261656
uniprot
proteins
sequence_length
484
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10531011, ECO:0000269|PubMed:16459298}. Nucleus {ECO:0000269|PubMed:10531011}. Cell projection, cilium {ECO:0000269|PubMed:20956384}. Note=Recruited to cilia in response to smoothened signaling, leading to dissociation from GLI (GI1, GLI2 and GLI3) transcription factors. {ECO:0000269|PubMed:20956384}.
uniprot
proteins