Slc15a3
entrez
246239
canonical
uniprot
Q924V4
canonical
ensembl
ENSRNOG00000021644
resolver
ensembl
ENSRNOG00055018452
resolver
ensembl
ENSRNOG00060025431
resolver
ensembl
ENSRNOG00065025973
resolver
ensp
ENSRNOP00000034275
resolver
ensp
ENSRNOP00055025304
resolver
ensp
ENSRNOP00060036527
resolver
ensp
ENSRNOP00065036654
resolver
enst
ENSRNOT00000029443
resolver
enst
ENSRNOT00055031347
resolver
enst
ENSRNOT00060044027
resolver
enst
ENSRNOT00065044758
resolver
genesymbol
Slc15a3
resolver
genesymbol_syn
Pht2
resolver
uniprot_entry
S15A3_RAT
resolver
amino_acid_sequence
MSALRAEQQPSRSGERQPLVAQGRWGPRRWRRTAAAAVLLVEMLERAAFFGVTSNLVLYLNSLNFNWDGEHASRATLLFLGASYLLAPVGGWLADVYLGRFLAISLSLLLYLAATGLLLTTITDDGRRSFCGEMPELPLKPACPSANCQGSWSSPYCATTLYLVLLLLALAASSVRSNLTSFGADQVMDLGRDATRRFFNWFYWSINLGAILSLLVVAFIEQNISFLQGYSIIVGLVGLAFFIFLIATPVFITKPPTGSQVSSMLNLAFQNCCPGWQWWRRPSSRNSEGAHLLPDQRSNQPGPSPQEDMANFQVLLKVLPVMVTLVPYWMVYFQMQSTYVLQGLHLHIPNIFRTNPNISLPLRSDSSNYRIPEAWLLLANVAVILILVPVKDHLIDPLLLRCKLLPSALQKMALGMFFGFTSIIVAGVLEKERLQYIAANQTVPQLIGKDLYYAAPLSIWWQIPQYLLIGISEIFASIPGLEFAYSEAPRSMQGAIMGIFFCLSGVGSLLGSGLVALLSLPGGWMYCPKDFGNINNCRMDLYFFLLAGIQAVTAVLFLWIAGRYERTRQDPDSQNSTSRVRG
uniprot
proteins
function
FUNCTION: Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (PubMed:11336635). Preferably binds to short peptides with a basic residue at the first position and a hydrophobic residue at the second position (By similarity). Also able to transport carnosine (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity). {ECO:0000250|UniProtKB:Q8BPX9, ECO:0000250|UniProtKB:Q8IY34, ECO:0000269|PubMed:11336635}.
uniprot
proteins
mass_dalton
64593
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family
uniprot
proteins
pubmed
11336635
uniprot
proteins
sequence_length
582
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:11336635}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IY34}. Endosome membrane {ECO:0000250|UniProtKB:Q8BPX9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IY34}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..56; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q8IY34"; TRANSMEM 75..90; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q8IY34"; TRANSMEM 103..118; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q8IY34"; TRANSMEM 160..175; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q8IY34"; TRANSMEM 201..220; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q8IY34"; TRANSMEM 227..247; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q8IY34"; TRANSMEM 318..336; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q8IY34"; TRANSMEM 374..388; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q8IY34"; TRANSMEM 412..428; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q8IY34"; TRANSMEM 466..476; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q8IY34"; TRANSMEM 499..518; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q8IY34"; TRANSMEM 541..561; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q8IY34
uniprot
proteins