Q63313
uniprot
Q63313
canonical
amino_acid_sequence
MKSATGPLLPTLLGLLLLSIPRTQGVNPAMVVRITDKGLEYAAKEGLLSLQRELYKITLPDFSGDFKIKAVGRGQYEFHSLEIQSCQLRGSSLKPLPGRGLSLSISDSSISVRGKWKVRRSFVKLHGSFDLDVKSVTISVDLLLGVDPSERPTVTASGCSNRIRDLELHVSGNVGWLLNLFHNQIESKLQKVLESKICEMIQKSVTSDLQPYLQTLPVTADIDTILGIDYSLVAAPQAKAQTLDVMFKGEIFNRNHRSPVTTPTPTMSLPEDSKQMVYFAISDQAFNIATRVYHQAGYLNFTITDDMLPPDSNIRLNTKAFRPFTPLITRKYPDMNLELLGTVVSAPLLNVSPGNLSLAPQMEIEGFVILPSSARESVFRLGVVTNVFVSLTFDNSKVTGMLHPEKAQVRLIESKVGMFNVNLFQAFLNYYLLNSLYPDVNDELAKGFPLPLPRRIKLHDLDFQIHKNFLYLGANVQYMRV
uniprot
proteins
function
FUNCTION: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide. {ECO:0000250|UniProtKB:P18428}.
uniprot
proteins
mass_dalton
53600
uniprot
proteins
protein_family
BPI/LBP family
uniprot
proteins
protein_family
BPI/LBP/Plunc superfamily
uniprot
proteins
pubmed
8021509
uniprot
proteins
sequence_length
481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P18428}. Cytoplasmic granule membrane {ECO:0000250|UniProtKB:P17213}. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. {ECO:0000250|UniProtKB:P17213}.
uniprot
proteins