PDCD5
entrez
9141
canonical
uniprot
O14737
canonical
ensembl
ENSG00000105185
resolver
ensp
ENSP00000466214
resolver
ensp
ENSP00000476525
resolver
genesymbol
PDCD5
resolver
genesymbol_syn
TFAR19
resolver
hgnc
HGNC:8764
resolver
uniprot
B4DE64
resolver
uniprot
Q53YC9
resolver
uniprot
Q6IB70
resolver
uniprot_entry
PDCD5_HUMAN
resolver
uniprot_sec
B4DE64
resolver
uniprot_sec
Q53YC9
resolver
uniprot_sec
Q6IB70
resolver
amino_acid_sequence
MADEELEALRRQRLAELQAKHGDPGDAAQQEAKHREAEMRNSILAQVLDQSARARLSNLALVKPEKTKAVENYLIQMARYGQLSEKVSEQGLIEILKKVSQQTEKTTTVKFNRRKVMDSDEDDDY
uniprot
proteins
function
FUNCTION: In response to DNA damage, associates with TP53/p53 to prevent MDM2-mediated degradation of TP53 and promote TP53-mediated signaling (PubMed:19616514, PubMed:22914926, PubMed:28051100). Also protects KAT5/TIP60 from degradation, which further promotes TP53/p53-mediated signaling (PubMed:19308289). {ECO:0000269|PubMed:19308289, ECO:0000269|PubMed:19616514, ECO:0000269|PubMed:22914926, ECO:0000269|PubMed:28051100}.
uniprot
proteins
mass_dalton
14285
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-119 by casein kinase II (PubMed:19616514, PubMed:28051100). Dephosphorylated at Ser-119 by PPEF1, which promotes its degradation by the proteasome (PubMed:28051100). {ECO:0000269|PubMed:19616514, ECO:0000269|PubMed:28051100}.
uniprot
proteins
protein_family
PDCD5 family
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19308289
uniprot
proteins
pubmed
19358820
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19616514
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22914926
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28051100
uniprot
proteins
pubmed
9920759
uniprot
proteins
sequence_length
125
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19308289, ECO:0000269|PubMed:22914926, ECO:0000269|PubMed:28051100}. Cytoplasm, cytosol {ECO:0000269|PubMed:22914926, ECO:0000269|PubMed:28051100}. Note=Accumulates in the nucleus in response to genotoxic stress. {ECO:0000269|PubMed:22914926, ECO:0000269|PubMed:28051100}.
uniprot
proteins