Gabrb2
entrez
14401
canonical
uniprot
P63137
canonical
ensembl
ENSMUSG00000007653
resolver
ensp
ENSMUSP00000007797
resolver
ensp
ENSMUSP00000141868
resolver
ensp
ENSMUSP00000198624
resolver
ensp
ENSMUSP00000198625
resolver
genesymbol
Gabrb2
resolver
genesymbol_syn
Gabrb-2
resolver
uniprot
A6H6R7
resolver
uniprot
D1LYT3
resolver
uniprot
P15432
resolver
uniprot_entry
GBRB2_MOUSE
resolver
uniprot_sec
A6H6R7
resolver
uniprot_sec
D1LYT3
resolver
uniprot_sec
P15432
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by benzodiazepines and the anesthetic etomidate (By similarity). Inhibited by the antagonist bicuculline (By similarity). Potentiated by histamine (By similarity). {ECO:0000250|UniProtKB:P0C2W5, ECO:0000250|UniProtKB:P47870, ECO:0000250|UniProtKB:P63138}.
uniprot
proteins
amino_acid_sequence
MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAANANNEKMRLDVNKMFYKDIKQNGTQYRSLWDPTGDLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
uniprot
proteins
function
FUNCTION: Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:27129275). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:27129275). Extrasynaptic beta-2 receptors contribute to the tonic GABAergic inhibition (By similarity). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity). {ECO:0000250|UniProtKB:P08219, ECO:0000250|UniProtKB:P47870, ECO:0000250|UniProtKB:P63138, ECO:0000269|PubMed:27129275}.
uniprot
proteins
mass_dalton
59197
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:27129275}.
uniprot
proteins
protein_family
GABRB2 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19763268
uniprot
proteins
pubmed
27129275
uniprot
proteins
pubmed
7893750
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P63138}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P47870}. Cell membrane {ECO:0000250|UniProtKB:P63138}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P47870}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P63138}.
uniprot
proteins
transmembrane_region
TRANSMEM 245..266; /note="Helical"; /evidence="ECO:0000305"; TRANSMEM 270..292; /note="Helical"; /evidence="ECO:0000305"; TRANSMEM 304..326; /note="Helical"; /evidence="ECO:0000305"; TRANSMEM 490..511; /note="Helical"; /evidence="ECO:0000305
uniprot
proteins