Slc1a3
entrez
20512
canonical
uniprot
P56564
canonical
ensembl
ENSMUSG00000005360
resolver
ensp
ENSMUSP00000005493
resolver
enst
ENSMUST00000005493
resolver
genesymbol
Slc1a3
resolver
genesymbol_syn
Eaat1
resolver
genesymbol_syn
Gmt1
resolver
uniprot
Q543U3
resolver
uniprot
Q99P53
resolver
uniprot_entry
EAA1_MOUSE
resolver
uniprot_entry
Q543U3_MOUSE
resolver
uniprot_sec
Q99P53
resolver
amino_acid_sequence
MTKSNGEEPRMGGRMERLQQGVRKRTLLAKKKVQSLTKEDVKSYLFRNAFVLLTVTAVIVGTILGFALRPYKMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMYREGKIVQVTAADAFLDLIRNMFPPNLVEACFKQFKTSYEKRSFKVPIQSNETLLGAVINNVSEAMETLTRIREEMVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPLGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEALAAIFIAQVNNFDLNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNEPEKPVADSETKM
uniprot
proteins
function
FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:28032905, PubMed:7903437). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (PubMed:15363892, PubMed:15390100, PubMed:16880397). {ECO:0000250|UniProtKB:O57321, ECO:0000269|PubMed:15363892, ECO:0000269|PubMed:15390100, ECO:0000269|PubMed:16880397, ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:7903437}.
uniprot
proteins
mass_dalton
59622
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:19656770}.
uniprot
proteins
protein_family
Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family
uniprot
proteins
protein_family
SLC1A3 subfamily
uniprot
proteins
pubmed
15363892
uniprot
proteins
pubmed
15390100
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16880397
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28032905
uniprot
proteins
pubmed
7903437
uniprot
proteins
sequence_length
543
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:7903437}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..68; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 87..108; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 123..145; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 237..260; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 270..297; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 319..340; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 386..412; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 473..494; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P43003
uniprot
proteins