GRWD1
entrez
83743
canonical
uniprot
Q9BQ67
canonical
ensembl
ENSG00000105447
resolver
ensp
ENSP00000253237
resolver
ensp
ENSP00000598914
resolver
enst
ENST00000253237
resolver
enst
ENST00000928855
resolver
genesymbol
GRWD1
resolver
genesymbol_syn
GRWD
resolver
genesymbol_syn
KIAA1942
resolver
genesymbol_syn
WDR28
resolver
hgnc
HGNC:21270
resolver
uniprot
A0MNN5
resolver
uniprot
Q8TF59
resolver
uniprot_entry
GRWD1_HUMAN
resolver
uniprot_sec
A0MNN5
resolver
uniprot_sec
Q8TF59
resolver
amino_acid_sequence
MAARKGRRRTCETGEPMEAESGDTSSEGPAQVYLPGRGPPLREGEELVMDEEAYVLYHRAQTGAPCLSFDIVRDHLGDNRTELPLTLYLCAGTQAESAQSNRLMMLRMHNLHGTKPPPSEGSDEEEEEEDEEDEEERKPQLELAMVPHYGGINRVRVSWLGEEPVAGVWSEKGQVEVFALRRLLQVVEEPQALAAFLRDEQAQMKPIFSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREPFLLSGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADHQITQWDLAVERDPEAGDVEADPGLADLPQQLLFVHQGETELKELHWHPQCPGLLVSTALSGFTIFRTISV
uniprot
proteins
disease_involvement
DISEASE: Diarrhea 14, congenital (DIAR14) [MIM:621160]: An autosomal recessive disorder characterized by diarrhea manifesting within the first year of life, and diffuse arterial hypoplasia. {ECO:0000269|PubMed:40174224}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Histone binding protein that regulates chromatin dynamics and loading of minichromosome maintenance (MCM) complex at replication origins, possibly by promoting chromatin openness (PubMed:25990725). Plays a role in ribosomal biogenesis (PubMed:15885502). {ECO:0000269|PubMed:15885502, ECO:0000269|PubMed:25990725}.
uniprot
proteins
mass_dalton
49419
uniprot
proteins
pubmed
11853319
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
14990995
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15885502
uniprot
proteins
pubmed
17041588
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23349634
uniprot
proteins
pubmed
25990725
uniprot
proteins
pubmed
40174224
uniprot
proteins
sequence_length
446
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Nucleus {ECO:0000269|PubMed:15885502, ECO:0000269|PubMed:25990725, ECO:0000269|PubMed:40174224}. Chromosome {ECO:0000269|PubMed:25990725}. Note=Present in the nucleus throughout interphase and is detached from chromatin at the onset of mitosis and rebinds at telophase when the pre-replication complexes (pre-RC) is formed (PubMed:25990725). {ECO:0000269|PubMed:25990725}.
uniprot
proteins