Net1
entrez
56349
canonical
uniprot
Q9Z206
canonical
ensembl
ENSMUSG00000021215
resolver
ensp
ENSMUSP00000089464
resolver
ensp
ENSMUSP00000097529
resolver
genesymbol
Net1
resolver
genesymbol_syn
Arhgef8
resolver
uniprot
Q3USZ7
resolver
uniprot
Q8C4I0
resolver
uniprot
Q9Z1L7
resolver
uniprot_entry
ARHG8_MOUSE
resolver
uniprot_entry
Q3USZ7_MOUSE
resolver
uniprot_sec
Q8C4I0
resolver
uniprot_sec
Q9Z1L7
resolver
amino_acid_sequence
MEPEPAAQKQPRPRRRSRRVSMLSEEPAAGLPADTPGPAANERCSLRRGSSFTFLTPGPHWDFTLKRKRREKDDDAVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRGDHRSPASAQKSFSRSTVPTPTKRRSSALWSEMLDINMKESLTTREIKRQEAIYELSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDAYIPLHEDLLARIGEATKPDGTVEQIGHILVNWLPGLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILRHTPKDHRDVQLLEEAILIIQGVLSDINLKKGESECQYYINKLEYLDEKQKDPRIEASKVLLCHGELKNKSGHKLYIFLFQDILVLTRPVTRNERHLYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFGNSDKAKNIFRVRFQDPSPGHSHTLQANDVFHKQQWFNCIRAAIAPFQRAASPLELQGLPDLHEECEENNPSAGNLRAQRRSCVVPGVMQIDEESALDCGSSVQTVEDTRNMKAQRPQPGLRRARDKAQSGGKKKETLV
uniprot
proteins
function
FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway. Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:9670022}.
uniprot
proteins
mass_dalton
67734
uniprot
proteins
mutagenesis
MUTAGEN 12..16; /note="RPRRR->APAAA: Leads to cytoplasmic relocalization; when associated with 67-A--A-70."; /evidence="ECO:0000269|PubMed:11839749"; MUTAGEN 67..70; /note="RKRR->AAAA: Leads to cytoplasmic relocalization; when associated with 12-A--A-16."; /evidence="ECO:0000269|PubMed:11839749"; MUTAGEN 321; /note="L->E: Inhibits transformation by N-terminal truncated form."; /evidence="ECO:0000269|PubMed:9670022"; MUTAGEN 492; /note="W->L: Inhibits transformation by N-terminal truncated form."; /evidence="ECO:0000269|PubMed:9670022
uniprot
proteins
pubmed
11350080
uniprot
proteins
pubmed
11839749
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
9535835
uniprot
proteins
pubmed
9670022
uniprot
proteins
sequence_length
595
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11839749}. Nucleus {ECO:0000269|PubMed:11839749}.
uniprot
proteins