H3-3b
entrez
117056
canonical
uniprot
P84245
canonical
ensembl
ENSRNOG00000003220
resolver
ensembl
ENSRNOG00000006532
resolver
ensembl
ENSRNOG00055012486
resolver
ensembl
ENSRNOG00055013215
resolver
ensembl
ENSRNOG00055032581
resolver
ensembl
ENSRNOG00060007048
resolver
ensembl
ENSRNOG00060025541
resolver
ensembl
ENSRNOG00060031181
resolver
ensembl
ENSRNOG00065017038
resolver
ensembl
ENSRNOG00065021089
resolver
ensp
ENSRNOP00000004329
resolver
ensp
ENSRNOP00000040434
resolver
ensp
ENSRNOP00055017225
resolver
ensp
ENSRNOP00055018408
resolver
ensp
ENSRNOP00055046453
resolver
ensp
ENSRNOP00060008694
resolver
ensp
ENSRNOP00060036675
resolver
ensp
ENSRNOP00060044883
resolver
ensp
ENSRNOP00065022494
resolver
ensp
ENSRNOP00065028926
resolver
enst
ENSRNOT00000004329
resolver
enst
ENSRNOT00000050223
resolver
enst
ENSRNOT00055021290
resolver
enst
ENSRNOT00055022653
resolver
enst
ENSRNOT00055056311
resolver
enst
ENSRNOT00060011575
resolver
enst
ENSRNOT00060044229
resolver
enst
ENSRNOT00060054108
resolver
enst
ENSRNOT00065028436
resolver
enst
ENSRNOT00065035867
resolver
genesymbol
H3-3b
resolver
genesymbol
H3f3b
resolver
genesymbol_syn
H3.3b
resolver
genesymbol_syn
H3f3a
resolver
genesymbol_syn
H3f3b
resolver
uniprot
A6HKT3
resolver
uniprot
B0BMY8
resolver
uniprot
P06351
resolver
uniprot
P33155
resolver
uniprot
Q5RJM5
resolver
uniprot
Q9V3W4
resolver
uniprot_entry
A6HKT3_RAT
resolver
uniprot_entry
H33_RAT
resolver
uniprot_sec
B0BMY8
resolver
uniprot_sec
P06351
resolver
uniprot_sec
P33155
resolver
uniprot_sec
Q5RJM5
resolver
uniprot_sec
Q9V3W4
resolver
amino_acid_sequence
MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
uniprot
proteins
function
FUNCTION: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000250|UniProtKB:P84243}.
uniprot
proteins
mass_dalton
15328
uniprot
proteins
mutagenesis
MUTAGEN 6; /note="Q->A: Abolished dopaminylation by TGM2. Impaired regulation of relapse-related transcriptional plasticity in the reward system."; /evidence="ECO:0000269|PubMed:32273471
uniprot
proteins
post_translational_modification
PTM: Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. {ECO:0000250|UniProtKB:P84243}.; PTM: Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription. {ECO:0000250|UniProtKB:P84243}.; PTM: Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters. {ECO:0000250|UniProtKB:P84243}.; PTM: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 and Lys-80. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me), which are linked to gene repression, are underrepresented. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication. {ECO:0000250|UniProtKB:P84243}.; PTM: Phosphorylated at Thr-4 (H3T3ph) by VRK1 (By similarity). Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes. {ECO:0000250|UniProtKB:P84243}.; PTM: Monoubiquitinated at Lys-15 (H3K14ub), Lys-19 (H3K18ub) and Lys-24 (H3K23ub) by UHRF1 and HLTF at hemimethylated DNA sites following DNA replication, promoting recruitment of DNMT1 DNA methyltransferase and replication-coupled DNA methylation maintenance (By similarity). Monoubiquitinated at Lys-15 (H3K14ub) by G2E3: H3K14ub represents a specific tag for heterochromatin formation by facilitating the deposition of H3K9me3 (By similarity). Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination (By similarity). Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins (By similarity). Ubiquitinated in testes (PubMed:9582357). {ECO:0000250|UniProtKB:P68431, ECO:0000269|PubMed:9582357}.; PTM: Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression. {ECO:0000250|UniProtKB:P84243}.; PTM: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. {ECO:0000250|UniProtKB:P84243}.; PTM: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. {ECO:0000250|UniProtKB:P68433}.; PTM: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair. {ECO:0000250|UniProtKB:P84243}.; PTM: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac). {ECO:0000250|UniProtKB:P68431}.; PTM: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity). {ECO:0000250|UniProtKB:P84243}.; PTM: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (PubMed:32273471). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (PubMed:32273471). {ECO:0000269|PubMed:32273471}.; PTM: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. {ECO:0000250|UniProtKB:P84243}.
uniprot
proteins
protein_family
Histone H3 family
uniprot
proteins
pubmed
12560483
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19343714
uniprot
proteins
pubmed
32273471
uniprot
proteins
pubmed
7877725
uniprot
proteins
pubmed
9582357
uniprot
proteins
sequence_length
136
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
uniprot
proteins