Chm
entrez
24942
canonical
uniprot
P37727
canonical
ensembl
ENSRNOG00000000161
resolver
ensp
ENSRNOP00000000174
resolver
enst
ENSRNOT00000000174
resolver
genesymbol
Chm
resolver
genesymbol_syn
Rep1
resolver
uniprot
G3V607
resolver
uniprot_entry
G3V607_RAT
resolver
uniprot_entry
RAE1_RAT
resolver
amino_acid_sequence
MADNLPSDFDVIVIGTGLPESIIAAACSRSGQRVLHVDSRSYYGGNWASFSFSGLLSWLKEYQENNDVVTENSMWQEQILENEEAIPLSSKDKTIQHVEVFCYASQDLHKDVEEAGALQKNHASVTSAQSAEAAEAAETSCLPTAVEPLSMGSCEIPAEQSQCPGPESSPEVNDAEATGKKENSDAKSSTEEPSENVPKVQDNTETPKKNRITYSQIIKEGRRFNIDLVSQLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFREGTVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCVEYEEHPDEYRAYEGTTFSEYLKTQKLTPNLQYFVLHSIAMTSETTSCTVDGLKATKKFLQCLGRYGNTPFLFPLYGQGELPQCFCRMCAVFGGIYCLRHSVQCLVVDKESRKCKAVIDQFGQRIISKHFIIEDSYLSENTCSRVQYRQISRAVLITDGSVLKTDADQQVSILAVPAEEPGSFGVRVIELCSSTMTCMKGTYLVHLTCMSSKTAREDLERVVQKLFTPYTEIEAENEQVEKPRLLWALYFNMRDSSDISRDCYNDLPSNVYVCSGPDSGLGNDNAVKQAETLFQQICPNEDFCPAPPNPEDIVLDGDSSQQEVPESSVTPETNSETPKESTVLGNPEEPSE
uniprot
proteins
function
FUNCTION: Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. {ECO:0000269|PubMed:12356470, ECO:0000269|PubMed:12620235, ECO:0000269|PubMed:15186776, ECO:0000269|PubMed:1525821, ECO:0000269|PubMed:8513495}.
uniprot
proteins
mass_dalton
72480
uniprot
proteins
mutagenesis
MUTAGEN 279; /note="F->A: Abolishes association with RGGT."; /evidence="ECO:0000269|PubMed:12620235
uniprot
proteins
protein_family
Rab GDI family
uniprot
proteins
pubmed
11389151
uniprot
proteins
pubmed
11675392
uniprot
proteins
pubmed
12356470
uniprot
proteins
pubmed
12620235
uniprot
proteins
pubmed
15186776
uniprot
proteins
pubmed
1525821
uniprot
proteins
pubmed
8513495
uniprot
proteins
sequence_length
650
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12356470, ECO:0000269|PubMed:1525821, ECO:0000269|PubMed:8513495}.
uniprot
proteins