P98193
uniprot
P98193
canonical
amino_acid_sequence
MKTVILLTFLWGLSCALPVARYQNTESESSEERTGNLAQSPPPPMANSDHTDSSESGEELGSDRSQYRPAGGLSKSAGMDADKEEDEDDSGDDTFGDEDNGPGPEERQWGGPSRLDSDEDSADTTQSSEDSTSQENSAQDTPSDSKDHHSDEADSRPEAGDSTQDSESEEYRVGGGSEGESSHGDGSEFDDEGMQSDDPGSTRSDRGHTRMSSAGIRSEESKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEEDDRGELADSNSRETQSVSTEDFRSKEESRSETQEDTAETQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVASESRGDNPDNTSQTGDQRDSESSEEDRLNTFSSSESQSTEEQGDSESNESLSLSEESQESAQDEDSSSQEGLQSQSASRESRSQESQSEQDSRSEENRDSDSQDSSRSKEESNSTGSTSSSEEDNHPKNIEADNRKLIVDAYHNKPIGDQDDNDCQDGY
uniprot
proteins
function
FUNCTION: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
53058
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
8509401
uniprot
proteins
sequence_length
489
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus (By similarity). {ECO:0000250}.
uniprot
proteins