Fxyd3
entrez
17178
canonical
uniprot
Q61835
canonical
ensembl
ENSMUSG00000057092
resolver
ensp
ENSMUSP00000130245
resolver
enst
ENSMUST00000167369
resolver
genesymbol
Fxyd3
resolver
genesymbol_syn
Mat8
resolver
genesymbol_syn
Plml
resolver
uniprot
Q3TLM3
resolver
uniprot_entry
FXYD3_MOUSE
resolver
uniprot_entry
Q3TLM3_MOUSE
resolver
amino_acid_sequence
MQEVVLSLLVLLAGLPTLDANDPENKNDPFYYDWYSLRVGGLICAGILCALGIIVLMSGKCKCKFRQKPSHRPGEGPPLITPGSAHNC
uniprot
proteins
function
FUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:15743908). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (By similarity). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (By similarity). {ECO:0000250|UniProtKB:Q14802, ECO:0000269|PubMed:15743908}.
uniprot
proteins
mass_dalton
9526
uniprot
proteins
mutagenesis
MUTAGEN 5; /note="V->N: Does not lead to glycosylation, suggesting that the non-cleavable signal sequence remains partly or entirely embedded in the membrane."; /evidence="ECO:0000269|PubMed:15743908
uniprot
proteins
post_translational_modification
PTM: Glutathionylated. {ECO:0000250|UniProtKB:Q14802}.
uniprot
proteins
protein_family
FXYD family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15743908
uniprot
proteins
pubmed
7836447
uniprot
proteins
pubmed
7970700
uniprot
proteins
sequence_length
88
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins