BLOC1S2
entrez
282991
canonical
uniprot
Q6QNY1
canonical
ensembl
ENSG00000196072
resolver
ensp
ENSP00000359398
resolver
ensp
ENSP00000410865
resolver
ensp
ENSP00000481847
resolver
ensp
ENSP00000484340
resolver
ensp
ENSP00000551141
resolver
enst
ENST00000618916
resolver
genesymbol
BLOC1S2
resolver
genesymbol_syn
BLOS2
resolver
genesymbol_syn
CEAP
resolver
hgnc
HGNC:20984
resolver
uniprot
A0A087X1N6
resolver
uniprot
B4DQV2
resolver
uniprot
F1T0F0
resolver
uniprot
Q5W040
resolver
uniprot
Q8WUI8
resolver
uniprot_entry
A0A087X1N6_HUMAN
resolver
uniprot_entry
BL1S2_HUMAN
resolver
uniprot_entry
F1T0F0_HUMAN
resolver
uniprot_sec
B4DQV2
resolver
uniprot_sec
Q5W040
resolver
uniprot_sec
Q8WUI8
resolver
amino_acid_sequence
MAAAAEGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR
uniprot
proteins
function
FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May play a role in cell proliferation (PubMed:15381421). {ECO:0000250|UniProtKB:Q9CWG9, ECO:0000269|PubMed:15102850, ECO:0000269|PubMed:15381421, ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:25898167}.
uniprot
proteins
mass_dalton
15961
uniprot
proteins
protein_family
BLOC1S2 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15102850
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15381421
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17182842
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22203680
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25898167
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
142
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15381421}. Lysosome membrane {ECO:0000305|PubMed:25898167}. Note=Localizes to the centrosomes in a microtubule-dependent manner. {ECO:0000269|PubMed:15381421}.
uniprot
proteins