Slc6a18
entrez
29323
canonical
uniprot
Q62687
canonical
ensembl
ENSRNOG00000016253
resolver
ensp
ENSRNOP00000022346
resolver
ensp
ENSRNOP00000072758
resolver
ensp
ENSRNOP00000082226
resolver
ensp
ENSRNOP00000088766
resolver
enst
ENSRNOT00000022346
resolver
enst
ENSRNOT00000089941
resolver
enst
ENSRNOT00000096395
resolver
enst
ENSRNOT00000113926
resolver
genesymbol
Slc6a18
resolver
genesymbol_syn
B0at3
resolver
genesymbol_syn
Xtrp2
resolver
uniprot
A0A0G2K3S7
resolver
uniprot
A0A8I5ZTR9
resolver
uniprot
A0A8I6AA48
resolver
uniprot
G3V847
resolver
uniprot
Q5XIV7
resolver
uniprot_entry
A0A0G2K3S7_RAT
resolver
uniprot_entry
A0A8I5ZTR9_RAT
resolver
uniprot_entry
A0A8I6AA48_RAT
resolver
uniprot_entry
G3V847_RAT
resolver
uniprot_entry
Q5XIV7_RAT
resolver
uniprot_entry
S6A18_RAT
resolver
amino_acid_sequence
MAQASGMDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCHTHGGGAFLIPYFIALVFEGIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSVSFLVSLYYNTILLWVLWFFLNSFQHPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISNTGTIQWKLFLCLVACWTTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLPGATEGLTYLFTPNMKILQNSRVWLDAATQIFFSLSLAFGGHIAFASYNQPRNNCEKDAVTIALVNSMTSLYASITIFSIMGFKASNDYGRCLDRNILSLINEFDFPELSISRDEYPSVLMYLNATQPERVARLPLKTCHLEDFLDKSASGPGLAFIVFTEAVLHMPGASVWSVLFFGMLFTLGLSSMFGNMEGVITPLFDMGILPKGVPKETMTGVVCFICFLSAICFTLQSGSYWLEIFDSFAASLNLIIFAFMEVVGVIHVYGIKRFCDDIEWMTGRRPSLYWQVTWRVVSPMLLFGIFLSYIVLLAQSSPSYKAWNPQYEHFPSREEKLYPGWVQVTCVLLSFLPSLWVPGIALAQLLFQYRQRWKNTHLESALKPQESRGC
uniprot
proteins
function
FUNCTION: Symporter that transports one amino acid molecule together with two sodium and one chloride ions in kidneys and plays a role in the neutral amino acids reabsorption. Preferentially transports neutral amino acids such as L-glycine and L-alanine but also other neutral amino acids. Required CLTRN for cell surface expression and for its amino acid transporter activity. The transport mechanism is pH-independent. {ECO:0000250|UniProtKB:O88576}.
uniprot
proteins
mass_dalton
69556
uniprot
proteins
protein_family
SLC6A18 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
7943364
uniprot
proteins
sequence_length
615
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:O88576}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:O88576}; Multi-pass membrane protein {ECO:0000255}. Note=In kidneys localizes to the apical membrane in distal segments of the proximal tubule. Cell membrane expression is CLTRN-dependent. {ECO:0000250|UniProtKB:O88576}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 106..126; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 178..198; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 256..276; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 291..311; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 398..418; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 443..463; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 473..493; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 521..541; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 572..592; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins