Gpr155
entrez
68526
canonical
uniprot
A2AWR3
canonical
ensembl
ENSMUSG00000041762
resolver
ensp
ENSMUSP00000075788
resolver
ensp
ENSMUSP00000259467
resolver
ensp
ENSMUSP00000259471
resolver
ensp
ENSMUSP00000259476
resolver
ensp
ENSMUSP00000259480
resolver
genesymbol
Gpr155
resolver
uniprot
A2AWR2
resolver
uniprot
D7RXL9
resolver
uniprot
D7RXM0
resolver
uniprot
Q14BN5
resolver
uniprot
Q80UC0
resolver
uniprot
Q8R0W2
resolver
uniprot_entry
LYCHS_MOUSE
resolver
uniprot_sec
A2AWR2
resolver
uniprot_sec
D7RXL9
resolver
uniprot_sec
D7RXM0
resolver
uniprot_sec
Q14BN5
resolver
uniprot_sec
Q80UC0
resolver
uniprot_sec
Q8R0W2
resolver
amino_acid_sequence
MDSYFSAKNSTLAGDMNATWPASHGFNATGDPPSMSITRLFPALLECFGIVLCGYIAGRANIITSTQAKGLGNFVSRFALPALLFKNMVVLNFSNVDWAFLYSVLIGKASVFFIVCVLTLLVASPESRFSKAGLFPIFATQSNDFALGYPIVEALYQSTYPEYLQYIYLVAPISLMMLNPIGFIFCEIQKSKDTQNASQNKAKIVGLGFLRVLQNPIVFMVFVGIAFNFILDKKIPVYMENFLDGLANSFSGSALFYLGLTMVGKIRRLKKSAFVVLTLLITAKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFATQFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDAKPLAYAIQNVSFDISIISLVSLIWSLSILLLSKKYKQLPHMLTANLLIAQTIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAVSLFLLKKRESVQLPVGIIIISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSILIAGVSLMCMNRTTQAGHYEGFGQSQNHKPVEPGSTAFEENPAPTNEPELFPSSIPETSCCSCSLGNGELRCPSIEPVTNSSASGPMPSSFEKTDHCVSRCDSQSCILAQEEEQYLQSGDPQLTRHVLLCLLLIIGLFANLSSCLWWLFNHETGRLYVELQFFCAVFNFGQGFISFGIFGLDKHLIILPFKRRLEFLWNNKEAAADRESPVSEEIKMTCQQFVHYHRDLCIRNIVRERRCGAKTSAGTFCGCDLVNWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRFLQKSPEQSPPARTLRDHQEESYKEIGHSSPPSVSPKT
uniprot
proteins
function
FUNCTION: Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway (By similarity). Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disruption of the interaction between the GATOR1 and KICSTOR complexes and promotion of mTORC1 signaling (By similarity). Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition (By similarity). Binds indole-3-acetic acid and may play a role in tryptophan metabolism (By similarity). {ECO:0000250|UniProtKB:Q7Z3F1}.
uniprot
proteins
mass_dalton
96347
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20537985
uniprot
proteins
sequence_length
868
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q7Z3F1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7Z3F1}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..57; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1"; TRANSMEM 78..98; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1"; TRANSMEM 103..123; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1"; TRANSMEM 132..152; /note="Discontinuously helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1"; TRANSMEM 166..186; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1"; TRANSMEM 212..232; /note="Discontinuously helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1"; TRANSMEM 242..262; /note="Discontinuously helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1"; TRANSMEM 272..292; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1"; TRANSMEM 314..334; /note="Discontinuously helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1"; TRANSMEM 345..365; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1"; TRANSMEM 380..400; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1"; TRANSMEM 413..433; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1"; TRANSMEM 437..457; /note="Helical; Name=13"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1"; TRANSMEM 479..499; /note="Helical; Name=14"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1"; TRANSMEM 519..539; /note="Helical; Name=15"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1"; TRANSMEM 659..679; /note="Helical; Name=16"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1"; TRANSMEM 690..710; /note="Helical; Name=17"; /evidence="ECO:0000250|UniProtKB:Q7Z3F1
uniprot
proteins