Abcc6
entrez
27421
canonical
uniprot
Q9R1S7
canonical
ensembl
ENSMUSG00000030834
resolver
ensp
ENSMUSP00000002850
resolver
ensp
ENSMUSP00000242643
resolver
enst
ENSMUST00000002850
resolver
genesymbol
Abcc6
resolver
genesymbol_syn
Mrp6
resolver
uniprot
A2TAJ0
resolver
uniprot
A2TAJ1
resolver
uniprot
F8VPT2
resolver
uniprot
Q80YB6
resolver
uniprot_entry
MRP6_MOUSE
resolver
uniprot_sec
A2TAJ0
resolver
uniprot_sec
A2TAJ1
resolver
uniprot_sec
F8VPT2
resolver
uniprot_sec
Q80YB6
resolver
amino_acid_sequence
MNRGRSMATPGEQCAGLRVWNQTEQEPAAYHLLSLCFVRAASSWVPPMYLWVLGPIYLLYIHRHGRCYLRMSHLFKTKMVLGLALILLYTFNVAVPLWRIHQGVPQAPELLIHPTVWLTTMSFATFLIHMERRKGVRSSGVLFGYWLLCCILPGINTVQQASAGNFRQEPLHHLATYLCLSLVVAELVLSCLVDQPPFFSEDSQPLNPCPEAEASFPSKAMFWWASGLLWRGYKKLLGPKDLWSLGRENSSEELVSQLEREWRRSCNGLPGHKGHSSVGAPETEAFLQPERSQRGPLLRAIWRVFRSTFLLGTLSLVISDAFRFAVPKLLSLFLEFMGDRNSSAWTGWLLAVLMFAAACLQTLFEQQHMYRAKVLQMRLRTAITGLVYRKVLVLSSGSRKSSAAGDVVNLVSVDIQRLAESIIYLNGLWLLFLWIFVCFVYLWQLLGPSALTAVAVFLSLLPLNFFITKKRGFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWEHAFLERLLHIRGQELSALKTSTLLFSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQAFLPFSVHCIVQARVSFDRLAAFLCLEEVDPNGMIASNSRRSSKDRISVHNGTFAWSQESPPCLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGSVAYVPQEAWVQNTSVVENVCFRQELDLPWLQKVLDACALGSDVASFPAGVHTPIGEQGMNLSGGQKQRLSLARAVYKKAAIYLLDDPLAALDAHVSQQVFKQVIGPSGLLQGTTRILVTHTLHVLPQADRILVLANGTIAEMGSYQDLLQRNGALVGLLDGARQPAGTHDAATSDDLGGFPGGGRPTCRPDRPRPTEAAPVKGRSTSEVQMEASLDDPEATGLTAEEDSVRYGRVKTTIYLSYLRAVGTPLCTYTLFLFLCQQVASFSQGYWLSLWADDPVVDGRQMHAALRGWVFGLLGCLQAIGLFASMAAVFLGGARASGLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDTVDVDIPDKLRSLLTYAFGLLEVGLAVTMATPLAIVAILPLMVLYAGFQSLYVATSCQLRRLESARYSSVCSHMAETFQGSLVVRAFRAQASFTAQHDALMDENQRVSFPKLVADRWLATNLELLGNGLVFVAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYARIPKEAPWRLPTCAAQPLWPCGGQIEFRDFGLRHRPELPLAVQGVSLKIHAGEKVGIVGRTGAGKSSLAWGLLRLQEAAEGNIWIDGVPITHVGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQEHTDEGIWAALETVQLKAFVTSLPGQLQYECAGQGDDLSVGQKQLLCLARALLRKTQILILDEATASVDPGTEMQMQAALERWFTQCTVLLIAHRLRSVMDCARVLVMDEGQVAESGSPAQLLAQKGLFYRLAHESGLA
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
ec_number
7.6.2.3
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity). {ECO:0000250|UniProtKB:O95255}.; FUNCTION: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. {ECO:0000250|UniProtKB:O95255}.
uniprot
proteins
mass_dalton
164857
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:O95255}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCC family
uniprot
proteins
protein_family
Conjugate transporter (TC 3.A.1.208) subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15888484
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17360558
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23625951
uniprot
proteins
pubmed
24277820
uniprot
proteins
sequence_length
1498
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:15888484, ECO:0000269|PubMed:23625951}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:23625951}. Basal cell membrane {ECO:0000250|UniProtKB:O95255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical; Name=1"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 79..99; /note="Helical; Name=2"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 105..125; /note="Helical; Name=3"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 138..155; /note="Helical; Name=4"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 174..194; /note="Helical; Name=5"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 301..321; /note="Helical; Name=6"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 348..368; /note="Helical; Name=7"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 425..445; /note="Helical; Name=8"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 449..469; /note="Helical; Name=9"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 532..552; /note="Helical; Name=10"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 575..595; /note="Helical; Name=11"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 935..955; /note="Helical; Name=12"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 993..1013; /note="Helical; Name=13"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1057..1077; /note="Helical; Name=14"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1079..1099; /note="Helical; Name=15"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1171..1191; /note="Helical; Name=16"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1194..1214; /note="Helical; Name=17"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins