Plch2
entrez
269615
canonical
uniprot
A2AP18
canonical
ensembl
ENSMUSG00000029055
resolver
ensp
ENSMUSP00000101256
resolver
ensp
ENSMUSP00000118292
resolver
ensp
ENSMUSP00000122704
resolver
ensp
ENSMUSP00000206959
resolver
enst
ENSMUST00000139976
resolver
genesymbol
Plch2
resolver
genesymbol_syn
Plcl4
resolver
uniprot
A6PWW5
resolver
uniprot
F7C3A0
resolver
uniprot
F8VQ50
resolver
uniprot
Q3LUA7
resolver
uniprot
Q4QSC7
resolver
uniprot
Q6PAS6
resolver
uniprot
Q80WP6
resolver
uniprot
Q8BJV1
resolver
uniprot
Q8BWU4
resolver
uniprot
Q8BXN5
resolver
uniprot
Q8CFR1
resolver
uniprot_entry
F7C3A0_MOUSE
resolver
uniprot_entry
PLCH2_MOUSE
resolver
uniprot_entry
Q6PAS6_MOUSE
resolver
uniprot_sec
A6PWW5
resolver
uniprot_sec
F8VQ50
resolver
uniprot_sec
Q3LUA7
resolver
uniprot_sec
Q4QSC7
resolver
uniprot_sec
Q80WP6
resolver
uniprot_sec
Q8BJV1
resolver
uniprot_sec
Q8BWU4
resolver
uniprot_sec
Q8BXN5
resolver
uniprot_sec
Q8CFR1
resolver
activity_regulation
ACTIVITY REGULATION: Activity is stimulated by GNB1:GNG2. {ECO:0000250|UniProtKB:O75038}.
uniprot
proteins
amino_acid_sequence
MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRDTRLFPLQRPISPLCSLEPIAEEPALGPGLPLQAAAPTGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTLQLRIGGGRENEEPPLRPHNGGISSGPREGTSGRQTDSKSRSRVPGHLPVVRRAKSEGQVLSELSPTPAVYSDATGTDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIPGVSLGRLTSRPCLASAARPDLPPVTKSKSNPNLRVAGGLPTAPDELQPRPLAPRLTGHHPRPPWHHLTLVGLRDCPVSAKSKSLGDLTADDFAPSFQGSTSSLSCGLGSLGVAHQVLEPGIRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGSVGGPSFLRRSSSRSQSRVRAIASRARQAQERQQRLRGQDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKGAPEQVCGAADGQLLLRL
uniprot
proteins
ec_number
3.1.4.11
uniprot
proteins
function
FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain. {ECO:0000269|PubMed:15899900, ECO:0000269|PubMed:16107206}.
uniprot
proteins
mass_dalton
164297
uniprot
proteins
mutagenesis
MUTAGEN 415; /note="H->A: Inhibition of activity."; /evidence="ECO:0000269|PubMed:15899900
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15899900
uniprot
proteins
pubmed
16107206
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15899900}. Cell membrane {ECO:0000269|PubMed:15899900}; Peripheral membrane protein {ECO:0000305|PubMed:15899900}; Cytoplasmic side {ECO:0000305|PubMed:15899900}. Note=Localized predominantly at the plasma membrane through the PH domain. {ECO:0000269|PubMed:15899900}.
uniprot
proteins