Ezr
entrez
22350
canonical
uniprot
P26040
canonical
ensembl
ENSMUSG00000052397
resolver
ensp
ENSMUSP00000063734
resolver
enst
ENSMUST00000064234
resolver
genesymbol
Ezr
resolver
genesymbol_syn
Vil2
resolver
uniprot
Q3UL48
resolver
uniprot
Q4KML7
resolver
uniprot
Q80ZT8
resolver
uniprot
Q8CBU4
resolver
uniprot
Q9DCI1
resolver
uniprot_entry
EZRI_MOUSE
resolver
uniprot_entry
Q3UL48_MOUSE
resolver
uniprot_entry
Q4KML7_MOUSE
resolver
uniprot_entry
Q8CBU4_MOUSE
resolver
uniprot_sec
Q80ZT8
resolver
uniprot_sec
Q9DCI1
resolver
activity_regulation
ACTIVITY REGULATION: A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding. {ECO:0000269|PubMed:9456324}.
uniprot
proteins
amino_acid_sequence
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLQYVDNKGFPTWLKLDKKVSAQEVRKENPVQFKFRAKFYPEDVAEELIQDITQKLFFLQVKDGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEMHKSGYLSSERLIPQRVMDQHKLSRDQWEDRIQVWHAEHRGMLKDSAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMLREKEELMLRLQDYEQKTKRAEKELSEQIEKALQLEEERRRAQEEAERLEADRMAALRAKEELERQAQDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVNYHVQEGLQDEGAEPMGYSAELSSEGILDDRNEEKRITEAEKNERVQRQLLTLSNELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAM
uniprot
proteins
function
FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
69407
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. {ECO:0000269|PubMed:9456324}.; PTM: S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex. {ECO:0000250|UniProtKB:P15311}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15797715
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1955455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21289089
uniprot
proteins
pubmed
21745462
uniprot
proteins
pubmed
24285636
uniprot
proteins
pubmed
9456324
uniprot
proteins
pubmed
9472040
uniprot
proteins
sequence_length
586
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P15311}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15311}; Cytoplasmic side {ECO:0000250|UniProtKB:P15311}. Cell projection {ECO:0000250|UniProtKB:P15311}. Cell projection, microvillus membrane {ECO:0000250|UniProtKB:P15311}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15311}; Cytoplasmic side {ECO:0000250|UniProtKB:P15311}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:P15311}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15311}; Cytoplasmic side {ECO:0000250|UniProtKB:P15311}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P15311}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P15311}. Cell projection, microvillus {ECO:0000269|PubMed:9472040}. Note=Localization to the apical membrane of parietal cells depends on the interaction with PALS1. Microvillar peripheral membrane protein (cytoplasmic side). Localizes to cell extensions and peripheral processes of astrocytes (By similarity). {ECO:0000250|UniProtKB:P15311, ECO:0000250|UniProtKB:P31977}.
uniprot
proteins