Rasgrp2
entrez
19395
canonical
uniprot
Q9QUG9
canonical
ensembl
ENSMUSG00000032946
resolver
ensp
ENSMUSP00000041135
resolver
ensp
ENSMUSP00000109100
resolver
ensp
ENSMUSP00000109104
resolver
ensp
ENSMUSP00000129873
resolver
ensp
ENSMUSP00000315296
resolver
ensp
ENSMUSP00000315297
resolver
ensp
ENSMUSP00000315299
resolver
ensp
ENSMUSP00000315305
resolver
ensp
ENSMUSP00000315310
resolver
ensp
ENSMUSP00000315321
resolver
genesymbol
Rasgrp2
resolver
uniprot
O09004
resolver
uniprot
Q80WC0
resolver
uniprot
Q8BSC8
resolver
uniprot_entry
GRP2_MOUSE
resolver
uniprot_sec
O09004
resolver
uniprot_sec
Q80WC0
resolver
uniprot_sec
Q8BSC8
resolver
amino_acid_sequence
MTSTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLASKLLHFYQQSRKDNSNSLQMKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIESVPTYKWKRQVTQRNPVEQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTATQRALVITHFVHVAERLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPDTIKLWEGLTELVTATGNYSNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPGRTRLNGAKMRQLFCILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSVAKPKLDQALVAEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMISYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKERLSVECRRRAQSVSLEGSAPSPSPTHTHHRAFSFSLPRPGRRSSRPPEIREEEVQSVEDGVFDIHL
uniprot
proteins
function
FUNCTION: Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269|PubMed:10777492, ECO:0000269|PubMed:10913189, ECO:0000269|PubMed:11278453, ECO:0000269|PubMed:11432821, ECO:0000269|PubMed:12239348, ECO:0000269|PubMed:15334074, ECO:0000269|PubMed:16357324, ECO:0000269|PubMed:17492052, ECO:0000269|PubMed:9789079}.
uniprot
proteins
mass_dalton
69446
uniprot
proteins
protein_family
RASGRP family
uniprot
proteins
pubmed
10777492
uniprot
proteins
pubmed
10835426
uniprot
proteins
pubmed
10913189
uniprot
proteins
pubmed
11278453
uniprot
proteins
pubmed
11432821
uniprot
proteins
pubmed
12239348
uniprot
proteins
pubmed
15334074
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16357324
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17492052
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9341881
uniprot
proteins
pubmed
9789079
uniprot
proteins
sequence_length
608
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Found both in the cytosol and associated with membranes. Enriched at juxtamembrane areas and membrane ruffles. Localizes to the cell bodies and axons of striatal neurons. {ECO:0000250}.
uniprot
proteins