Lnx1
entrez
16924
canonical
uniprot
O70263
canonical
ensembl
ENSMUSG00000029228
resolver
ensp
ENSMUSP00000040098
resolver
ensp
ENSMUSP00000084405
resolver
ensp
ENSMUSP00000109159
resolver
ensp
ENSMUSP00000113035
resolver
ensp
ENSMUSP00000113565
resolver
ensp
ENSMUSP00000113837
resolver
ensp
ENSMUSP00000121094
resolver
ensp
ENSMUSP00000250068
resolver
enst
ENSMUST00000113531
resolver
enst
ENSMUST00000121690
resolver
enst
ENSMUST00000153543
resolver
genesymbol
Lnx1
resolver
genesymbol_syn
Lnx
resolver
uniprot
A0A097P8N4
resolver
uniprot
A4QPD4
resolver
uniprot
D3YTM4
resolver
uniprot
E9Q4N3
resolver
uniprot
E9Q6Q0
resolver
uniprot
O70264
resolver
uniprot
Q3UUJ9
resolver
uniprot
Q8BRI8
resolver
uniprot
Q8CFR3
resolver
uniprot_entry
A0A097P8N4_MOUSE
resolver
uniprot_entry
A4QPD4_MOUSE
resolver
uniprot_entry
E9Q4N3_MOUSE
resolver
uniprot_entry
E9Q6Q0_MOUSE
resolver
uniprot_entry
LNX1_MOUSE
resolver
uniprot_entry
Q3UUJ9_MOUSE
resolver
uniprot_sec
D3YTM4
resolver
uniprot_sec
O70264
resolver
uniprot_sec
Q8BRI8
resolver
uniprot_sec
Q8CFR3
resolver
amino_acid_sequence
MNQPDLADDPDPSPEPLCIVCGQNHSPEENHFYTYTEDVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVEKDFCPVDRKPVVLQHCKKSSILVNKLLNKLLVTCPFTEHCTEVLQRCDLQHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLMATTLSPEVSAAATISLMTDEPGLDNPAYVSSVEDGEPVANSSDSGRSNRTRARPFERSTMRSRSFKKINRALSALRRTKSGSVVANHVDQGRDNSENTTVPEVFPRLFHLIPDGEITSIKINRADPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLRLTVLREQKFRSRSNAHVPDSYGPRDDSFHVILNKSSPEEQLGIKLVRRVDEPGVFIFNVLNGGVADRHGQLEENDRVLAINGHDLRFGSPESAAHLIQASERRVHLVVSRQVRQSSPDIFQEAGWISNGQQSPGPGERNTASKPAATCHEKVVSVWKDPSESLGMTVGGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVNGIELTEVSRTEAVAILKSAPSSVVLKALEVKEQEAQEDCSPAALDSNHNVTPPGDWSPSWVMWLELPQYLCNCKDVILRRNTAGSLGFCIVGGYEEYSGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARMLKELKGRITLTIASWPGTFL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. {ECO:0000269|PubMed:11782429, ECO:0000269|PubMed:14990566, ECO:0000269|PubMed:9535908}.; FUNCTION: Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. {ECO:0000269|PubMed:9535908}.
uniprot
proteins
mass_dalton
80157
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="C->A: Loss of function."; /evidence="ECO:0000269|PubMed:11782429"; MUTAGEN 181; /note="P->A: No effect on binding to NUMB protein."; /evidence="ECO:0000269|PubMed:9535908"; MUTAGEN 182; /note="G->A: Slightly affects binding to NUMB protein."; /evidence="ECO:0000269|PubMed:9535908"; MUTAGEN 183; /note="L->A: Abolishes binding to NUMB protein."; /evidence="ECO:0000269|PubMed:9535908"; MUTAGEN 184; /note="D->A: Slightly affects binding to NUMB protein."; /evidence="ECO:0000269|PubMed:9535908"; MUTAGEN 185; /note="N->A: Abolishes binding to NUMB protein."; /evidence="ECO:0000269|PubMed:9535908"; MUTAGEN 186; /note="P->A: Slightly affects binding to NUMB protein."; /evidence="ECO:0000269|PubMed:9535908"; MUTAGEN 188; /note="Y->A: Abolishes binding to NUMB protein."; /evidence="ECO:0000269|PubMed:9535908"; MUTAGEN 188; /note="Y->F: No effect on binding to NUMB protein."; /evidence="ECO:0000269|PubMed:9535908
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
11782429
uniprot
proteins
pubmed
14990566
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16832352
uniprot
proteins
pubmed
9535908
uniprot
proteins
sequence_length
728
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins