HMOX1
entrez
3162
canonical
uniprot
P09601
canonical
ensembl
ENSG00000100292
resolver
ensp
ENSP00000216117
resolver
enst
ENST00000216117
resolver
genesymbol
HMOX1
resolver
genesymbol_syn
HO
resolver
genesymbol_syn
HO1
resolver
hgnc
HGNC:5013
resolver
uniprot
Q6FH11
resolver
uniprot_entry
HMOX1_HUMAN
resolver
uniprot_entry
Q6FH11_HUMAN
resolver
amino_acid_sequence
MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM
uniprot
proteins
disease_involvement
DISEASE: Heme oxygenase 1 deficiency (HMOX1D) [MIM:614034]: A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. {ECO:0000269|PubMed:9884342}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.14.14.18
uniprot
proteins
function
FUNCTION: [Heme oxygenase 1]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:11121422, PubMed:19556236, PubMed:7703255). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (PubMed:20055707). {ECO:0000269|PubMed:11121422, ECO:0000269|PubMed:19556236, ECO:0000269|PubMed:7703255, ECO:0000303|PubMed:20055707}.; FUNCTION: [Heme oxygenase 1]: (Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy. {ECO:0000269|PubMed:35239449}.; FUNCTION: [Heme oxygenase 1 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:7703255}.
uniprot
proteins
mass_dalton
32819
uniprot
proteins
mutagenesis
MUTAGEN 140; /note="D->A,H,N,F,L: Inactive as a heme oxygenase but active as a peroxidase."; /evidence="ECO:0000269|PubMed:11121422, ECO:0000269|PubMed:12842469"; MUTAGEN 270; /note="W->A: No effect on catalytic activity, oligomerization and localization to the endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:19556236"; MUTAGEN 270; /note="W->N: Significant reduction in catalytic activity, reduced oligomerization, reduced endoplasmic reticulum localization with cytoplasmic mislocalization."; /evidence="ECO:0000269|PubMed:19556236
uniprot
proteins
post_translational_modification
PTM: A soluble form arises by proteolytic removal of the membrane anchor. {ECO:0000305|PubMed:7703255}.
uniprot
proteins
protein_family
Heme oxygenase family
uniprot
proteins
pubmed
10467099
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11121422
uniprot
proteins
pubmed
12842469
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
19556236
uniprot
proteins
pubmed
20055707
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20855888
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22419571
uniprot
proteins
pubmed
2537723
uniprot
proteins
pubmed
27184847
uniprot
proteins
pubmed
2911585
uniprot
proteins
pubmed
3345742
uniprot
proteins
pubmed
35239449
uniprot
proteins
pubmed
7703255
uniprot
proteins
pubmed
9884342
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19556236, ECO:0000269|PubMed:22419571, ECO:0000269|PubMed:27184847}; Single-pass type IV membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000269|PubMed:22419571}.
uniprot
proteins
transmembrane_region
TRANSMEM 266..288; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins