Fxyd5
entrez
18301
canonical
uniprot
P97808
canonical
ensembl
ENSMUSG00000009687
resolver
ensp
ENSMUSP00000009831
resolver
ensp
ENSMUSP00000124203
resolver
ensp
ENSMUSP00000124219
resolver
ensp
ENSMUSP00000125065
resolver
ensp
ENSMUSP00000125285
resolver
ensp
ENSMUSP00000125398
resolver
enst
ENSMUST00000009831
resolver
enst
ENSMUST00000159924
resolver
enst
ENSMUST00000161684
resolver
enst
ENSMUST00000161805
resolver
enst
ENSMUST00000162087
resolver
enst
ENSMUST00000162116
resolver
genesymbol
Fxyd5
resolver
genesymbol_syn
Oit2
resolver
uniprot
F8WJA1
resolver
uniprot
Q3TDW1
resolver
uniprot_entry
F8WJA1_MOUSE
resolver
uniprot_entry
FXYD5_MOUSE
resolver
uniprot_sec
Q3TDW1
resolver
amino_acid_sequence
MSLSSRLCLLTIVALILPSRGQTPKKPTSIFTADQTSATTRDNVPDPDQTSPGVQTTPLIWTREEATGSQTAAQTETQQLTKMATSNPVSDPGPHTSSKKGTPAVSRIEPLSPSKNFMPPSYIEHPLDSNENNPFYYDDTTLRKRGLLVAAVLFITGIIILTSGKCRQLSQFCLNRHR
uniprot
proteins
function
FUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed:16148001, PubMed:17881459). May increase NKA activity by increasing the apparent affinity for Na(+) (PubMed:17881459). Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis (By similarity). {ECO:0000250|UniProtKB:Q96DB9, ECO:0000269|PubMed:16148001, ECO:0000269|PubMed:17881459}.
uniprot
proteins
mass_dalton
19454
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:17881459}.
uniprot
proteins
protein_family
FXYD family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16148001
uniprot
proteins
pubmed
17881459
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9032278
uniprot
proteins
sequence_length
178
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16148001}; Single-pass type I membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:16148001}; Single-pass type I membrane protein {ECO:0000305}. Note=In kidneys localizes to the basolateral membrane of the connecting tubule. {ECO:0000269|PubMed:16148001}.
uniprot
proteins
transmembrane_region
TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins