Slc15a1
entrez
56643
canonical
uniprot
Q9JIP7
canonical
ensembl
ENSMUSG00000025557
resolver
ensp
ENSMUSP00000085728
resolver
enst
ENSMUST00000088386
resolver
genesymbol
Slc15a1
resolver
genesymbol_syn
Pept1
resolver
uniprot
E9QMX3
resolver
uniprot
Q14BA3
resolver
uniprot
Q3UWE2
resolver
uniprot_entry
Q14BA3_MOUSE
resolver
uniprot_entry
Q3UWE2_MOUSE
resolver
uniprot_entry
S15A1_MOUSE
resolver
uniprot_sec
E9QMX3
resolver
amino_acid_sequence
MGMSKSRGCFGYPLSIFFIVVNEFCERFSYYGMRALLVLYFRNFLGWDDNLSTAIYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVISVSSINDLTDHDHNGSPDSLPVHVALSMVGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINGGSLLSTIITPILRVQQCGIHSQQACYPLAFGVPAALMAVALIVFVLGSGMYKKFQPQGNIMGKVAKCIGFAIKNRFRHRSKAYPKREHWLDWAKEKYDERLISQIKMVTKVMFLYIPLPMFWALFDQQGSRWTLQATTMNGKIGAIEIQPDQMQTVNAILIVIMVPIVDAVVYPLIAKCGFNFTSLKKMTVGMFLASMAFVVAAIVQVEIDKTLPVFPGGNQVQIKVLNIGNNNMTVHFPGNSVTLAQMSQTDTFMTFDIDKLTSINISSSGSPGVTTVAHDFEQGHRHTLLVWNPSQYRVVKDGLNQKPEKGENGIRFVNTLNEMVTIKMSGKVYENVTSHNASGYQFFPSGEKQYTINTTAVAPTCLTDFKSSNLDFGSAYTYVIRRASDGCLEVKEFEDIPPNTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAGAGHFPKQWAEYILFASLLLVVCVIFAIMARFYTYINPAEIEAQFDEDEKKKGIGKENPYSSLEPVSQTNM
uniprot
proteins
function
FUNCTION: Electrogenic proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and monovalently charged peptides with a proton to peptide stoichiometry of 1:1 or 2:1 (By similarity) (PubMed:11004485). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity). Mediates transepithelial transport of muramyl and N-formylated bacterial dipeptides contributing to recognition of pathogenic bacteria by the mucosal immune system (By similarity). {ECO:0000250|UniProtKB:P36836, ECO:0000250|UniProtKB:P46059, ECO:0000269|PubMed:11004485, ECO:0000269|PubMed:26320580}.
uniprot
proteins
mass_dalton
78560
uniprot
proteins
mutagenesis
MUTAGEN 453..456; /note="HDFE->AAFA,ERFR: Does not affect trypsin-binding."; /evidence="ECO:0000269|PubMed:26320580"; MUTAGEN 472..475; /note="RVVK->AVVA,EVVE: Does not affect trypsin-binding."; /evidence="ECO:0000269|PubMed:26320580"; MUTAGEN 476; /note="D->A: Does not affect trypsin-binding."; /evidence="ECO:0000269|PubMed:26320580"; MUTAGEN 509; /note="E->R: Does not affect trypsin-binding."; /evidence="ECO:0000269|PubMed:26320580"; MUTAGEN 515; /note="N->A: Does not affect trypsin-binding."; /evidence="ECO:0000269|PubMed:26320580"; MUTAGEN 550; /note="D->A: Reduced trypsin-binding; when associated with A-573."; /evidence="ECO:0000269|PubMed:26320580"; MUTAGEN 573; /note="E->A: Reduced trypsin-binding; when associated with A-550."; /evidence="ECO:0000269|PubMed:26320580
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family
uniprot
proteins
pubmed
11004485
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26320580
uniprot
proteins
sequence_length
709
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P46059}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the apical membrane of enterocytes. {ECO:0000250|UniProtKB:P46059}.
uniprot
proteins
transmembrane_region
TRANSMEM 1..21; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 54..74; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 83..103; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 119..139; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 162..182; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 199..219; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 328..348; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 586..606; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 621..641; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 647..667; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins