Gatd3
entrez
28295
canonical
uniprot
Q9D172
canonical
ensembl
ENSMUSG00000053329
resolver
ensp
ENSMUSP00000001242
resolver
ensp
ENSMUSP00000151605
resolver
enst
ENSMUST00000001242
resolver
genesymbol
Gatd3
resolver
genesymbol_syn
D10Jhu81e
resolver
genesymbol_syn
Gatd3a
resolver
uniprot_entry
GAL3A_MOUSE
resolver
amino_acid_sequence
MAAVRVLVAPRLASALLPLSRYHRAPSQRAALHSSAPRPGARVALVLSGCGVYDGTEIHEASAILVHLSRGGAEVQIFAPDVPQMHVIDHTKGEPSERESRNVLAESARIARGKITSLAQLNAANHDAAIFPGGFGAAKNLSTFAVDGKDCKVNKEVERVLKEFHGAKKPIGLCCIAPVLAAKVIKGVEVTVGHEQEEGGKWPYAGTAEAIKALGAKHCVKGVTEAHVDQKNKVVTTPAFMCETALHHIHDGIGAMVKNVLELTGK
uniprot
proteins
function
FUNCTION: Acts as a mitochondrial deglycase involved in the removal of early non-enzymatic glycation adducts from amino acids and nucleotides, thereby restricting the formation of advanced glycation end products (AGEs) within mitochondria. Required to maintain low levels of glycation on mitochondrial ribosomal RNA and proteins, supporting efficient mitochondrial gene expression. Contributes to mitochondrial homeostasis, normal respiratory capacity, and proper mitochondrial network organization. Acts also as a mitochondrial regulator of malate dehydrogenase MDH2 by competitively limiting the association of MDH2 with the mitochondrial deacetylase SIRT3, thereby preserving MDH2 acetylation and enzymatic activity. Through this mechanism, supports efficient conversion of malate to oxaloacetate, sustaining TCA cycle continuity and oxidative phosphorylation. {ECO:0000250|UniProtKB:P0DPI2}.
uniprot
proteins
mass_dalton
28090
uniprot
proteins
protein_family
GATD3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P0DPI2}.
uniprot
proteins