P07867
uniprot
P07867
canonical
activity_regulation
ACTIVITY REGULATION: Phospholipase A1 and lysophospholipase activities are inhibited by annexin II. {ECO:0000269|PubMed:1531641}.
uniprot
proteins
amino_acid_sequence
MGNHLQISVSLVLCIFIQSSACGQGVGTEPFGRNLGATEERKPLQKPEIRFLLFKDESDRLGCQLRPQHPETLQECGFNSSHPLVMIIHGWSVDGLLETWIWKIVGALKSRQSQPVNVGLVDWISLAYQHYAIAVRNTRVVGQEVAALLLWLEESMKFSRSKVHLIGYSLGAHVSGFAGSSMGGKRKIGRITGLDPAGPMFEGTSPNERLSPDDANFVDAIHTFTREHMGLSVGIKQPIAHYDFYPNGGSFQPGCHFLELYKHIAEHGLNAITQTINCAHERSVHLFIDSLQHSNLQNTGFQCSNMDSFSQGLCLNCKKGRCNSLGYDIRRIGHVKSKTLFLITRAQSPFKVYHYQFKIQFINQMEKPMEPTFTMTLLGTKEEIKKIPITLGEGITSNKTYSLLITLNKDIGELIMLKFKWENSAVWANVWNTVQTIMLWDTEPHYAGLIVKTIWVKAGETQQRMTFCPDNVDDLQLHPTQEKVFVKCDLKSKD
uniprot
proteins
ec_number
3.1.1.3
uniprot
proteins
ec_number
3.1.1.32
uniprot
proteins
ec_number
3.1.1.5
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (PubMed:1531641, PubMed:1770315, PubMed:1865764, PubMed:6747460, PubMed:7074125). Also exhibits lysophospholipase activity (PubMed:1531641). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (PubMed:1865764). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (By similarity). {ECO:0000250|UniProtKB:P11150, ECO:0000269|PubMed:1531641, ECO:0000269|PubMed:1770315, ECO:0000269|PubMed:1865764, ECO:0000269|PubMed:6747460, ECO:0000269|PubMed:7074125}.
uniprot
proteins
mass_dalton
55623
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
Lipase family
uniprot
proteins
pubmed
1531641
uniprot
proteins
pubmed
1770315
uniprot
proteins
pubmed
1865764
uniprot
proteins
pubmed
2322583
uniprot
proteins
pubmed
3470738
uniprot
proteins
pubmed
6747460
uniprot
proteins
pubmed
7074125
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P11150}.
uniprot
proteins