Slc9a5
entrez
277973
canonical
uniprot
B2RXE2
canonical
ensembl
ENSMUSG00000014786
resolver
ensp
ENSMUSP00000072893
resolver
ensp
ENSMUSP00000256461
resolver
ensp
ENSMUSP00000256465
resolver
enst
ENSMUST00000073149
resolver
genesymbol
Slc9a5
resolver
genesymbol_syn
Nhe5
resolver
uniprot_entry
SL9A5_MOUSE
resolver
amino_acid_sequence
MLSAALLLLPGLPLAGAGATEEPTQESGPLGEPPPGLALFRWQWHEVEAPYLVALWILVASLAKIVFHLSRKVTSLVPESCLLILLGLVLGGIVLAVAKKAEYQLEPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGVALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNQTLFIIIFGESLLNDAVTVVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTAVKYTMKTLASCAETVIFMLLGISAVDSSKWAWDSGLVLGTLFFILFFRALGVVLQTWALNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLRVKRSDYHKPTLNQELHEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMRRSAYRIRDQIWDVYYRLNIRDAISFVDQGGHVLSSTGLTLPSMPSRNSVAETSVTNLLRESGSGACLDLQVIDTVRSGRDREDAVMHHLLCGGLYKPRRRYKASCGRHFISEDAQERQDKEIFQQNMKRRLESFKSTKHNICFTKSKPRPRKTSHKKKDGVANPEATNGKPPRDLGFQDTAAVILTVESEEEEESDSSETEKEDDEGIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKELPWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSISSLESLASPPCTQPPTLTRLPPHPLVTEEPQVPIDLSSDPRSSFAFPPSLAKAGRSRSESSADIPQQELQPLMGHKDHTHLSPGTANSHWCIQFNRGGRL
uniprot
proteins
function
FUNCTION: Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Responsible for regulating intracellular pH homeostasis, in particular in neural tissues. Acts as a negative regulator of dendritic spine growth. Plays a role in postsynaptic remodeling and signaling. Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking. {ECO:0000250|UniProtKB:Q14940}.
uniprot
proteins
mass_dalton
99009
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKAA2; promotes its accumulation at the cell surface. Phosphorylated by CSNK2A1 in a manner favoring its beta-arrestin binding and endocytosis. {ECO:0000250|UniProtKB:Q14940}.
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21551074
uniprot
proteins
pubmed
28981195
uniprot
proteins
sequence_length
898
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q14940}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q14940}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:Q14940}; Multi-pass membrane protein {ECO:0000255}. Synaptic cell membrane {ECO:0000250|UniProtKB:Q14940}; Multi-pass membrane protein. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q14940}. Note=Cycles between recycling endosome and plasma membrane in response to diverse stimuli. Its internalization is clathrin- and beta-arrestin dependent and its plasma membrane insertion from the recycling endosomes requires phosphoinositide 3-kinase (PIK3CA) and SCAMP2. {ECO:0000250|UniProtKB:Q14940}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 77..97; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 107..127; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 138..158; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 250..270; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 280..300; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 335..355; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 364..384; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 402..422; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 432..452; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins