PDGFB
entrez
5155
canonical
uniprot
P01127
canonical
ensembl
ENSG00000100311
resolver
ensp
ENSP00000330382
resolver
ensp
ENSP00000370963
resolver
genesymbol
PDGFB
resolver
genesymbol_syn
PDGF2
resolver
genesymbol_syn
SIS
resolver
hgnc
HGNC:8800
resolver
uniprot
A0A384NYY3
resolver
uniprot
G3XAG8
resolver
uniprot
P78431
resolver
uniprot
Q15354
resolver
uniprot
Q6FHE7
resolver
uniprot
Q9UF23
resolver
uniprot_entry
A0A384NYY3_HUMAN
resolver
uniprot_entry
PDGFB_HUMAN
resolver
uniprot_sec
G3XAG8
resolver
uniprot_sec
P78431
resolver
uniprot_sec
Q15354
resolver
uniprot_sec
Q6FHE7
resolver
uniprot_sec
Q9UF23
resolver
amino_acid_sequence
MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA
uniprot
proteins
disease_involvement
DISEASE: Basal ganglia calcification, idiopathic, 5 (IBGC5) [MIM:615483]: A form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas. {ECO:0000269|PubMed:23913003, ECO:0000269|PubMed:26599395}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB. {ECO:0000269|PubMed:12660034}.
uniprot
proteins
function
FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). {ECO:0000250|UniProtKB:P31240, ECO:0000269|PubMed:26599395}.
uniprot
proteins
mass_dalton
27283
uniprot
proteins
protein_family
PDGF/VEGF growth factor family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11331882
uniprot
proteins
pubmed
12660034
uniprot
proteins
pubmed
1317862
uniprot
proteins
pubmed
1396586
uniprot
proteins
pubmed
15053742
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16393139
uniprot
proteins
pubmed
1661670
uniprot
proteins
pubmed
18483217
uniprot
proteins
pubmed
20534510
uniprot
proteins
pubmed
23913003
uniprot
proteins
pubmed
26599395
uniprot
proteins
pubmed
2991848
uniprot
proteins
pubmed
34530889
uniprot
proteins
pubmed
3456904
uniprot
proteins
pubmed
3472769
uniprot
proteins
pubmed
3517869
uniprot
proteins
pubmed
4033772
uniprot
proteins
pubmed
6306471
uniprot
proteins
pubmed
6327048
uniprot
proteins
pubmed
6329745
uniprot
proteins
pubmed
6740330
uniprot
proteins
pubmed
6844921
uniprot
proteins
pubmed
7659502
uniprot
proteins
pubmed
8988177
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted. Note=Released by platelets upon wounding.
uniprot
proteins