Pitpna
entrez
29525
canonical
uniprot
P16446
canonical
ensembl
ENSRNOG00000003846
resolver
ensp
ENSRNOP00000005368
resolver
enst
ENSRNOT00000005368
resolver
genesymbol
Pitpna
resolver
genesymbol_syn
Pitpn
resolver
uniprot_entry
PIPNA_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Phosphatidylinositol transfer activity is inhibited by N-ethylmaleimide. {ECO:0000269|PubMed:18636990}.
uniprot
proteins
amino_acid_sequence
MVLLKEYRVILPVSVDEYQVGQLYSVAEASKNETGGGEGVEVLVNEPYEKDDGEKGQYTHKIYHLQSKVPTFVRMLAPEGALNIHEKAWNAYPYCRTVITNEYMKEDFLIKIETWHKPDLGTQENVHKLEPEAWKHVEAIYIDIADRSQVLSKDYKAEEDPAKFKSIKTGRGPLGPNWKQELVNQKDCPYMCAYKLVTVKFKWWGLQNKVENFIHKQEKRLFTNFHRQLFCWLDKWVDLTMDDIRRMEEETKRQLDEMRQKDPVKGMTADD
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:18636990, PubMed:7568025). Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (By similarity). Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (By similarity). {ECO:0000250|UniProtKB:Q00169, ECO:0000269|PubMed:18636990, ECO:0000269|PubMed:7568025}.
uniprot
proteins
mass_dalton
31907
uniprot
proteins
mutagenesis
MUTAGEN 25; /note="S->F: Loss of phosphatidylinositol transfer activity but no significant effect on phosphatidylcholine transfer activity."; /evidence="ECO:0000269|PubMed:7568025"; MUTAGEN 59; /note="T->A: Reduced phosphatidylinositol and phosphatidylcholine transfer activity."; /evidence="ECO:0000269|PubMed:7568025"; MUTAGEN 59; /note="T->S,Q,V,I,N,D,E: Loss of phosphatidylinositol transfer activity but no significant effect on phosphatidylcholine transfer activity."; /evidence="ECO:0000269|PubMed:7568025"; MUTAGEN 60; /note="H->Q: No significant effect on phosphatidylinositol and phosphatidylcholine transfer activity."; /evidence="ECO:0000269|PubMed:7568025"; MUTAGEN 78; /note="P->L: Loss of phosphatidylinositol transfer activity but no significant effect on phosphatidylcholine transfer activity."; /evidence="ECO:0000269|PubMed:7568025"; MUTAGEN 198; /note="T->I: No significant effect on phosphatidylinositol and phosphatidylcholine transfer activity."; /evidence="ECO:0000269|PubMed:7568025"; MUTAGEN 248; /note="E->K: Loss of phosphatidylinositol transfer activity but no significant effect on phosphatidylcholine transfer activity."; /evidence="ECO:0000269|PubMed:7568025
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKC in a calcium and phosphatidylserine-dependent manner. {ECO:0000250|UniProtKB:P53810}.
uniprot
proteins
protein_family
PI transfer class I subfamily
uniprot
proteins
protein_family
PtdIns transfer protein family
uniprot
proteins
pubmed
11104777
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18636990
uniprot
proteins
pubmed
2777797
uniprot
proteins
pubmed
3606604
uniprot
proteins
pubmed
7568025
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18636990}. Nucleus {ECO:0000250|UniProtKB:P53810}. Note=Primarily localized in the cytosol in its closed state, is enriched on membranes in its open state where it facilitates lipid transfer. {ECO:0000269|PubMed:18636990}.
uniprot
proteins