Tmub1
entrez
362301
canonical
uniprot
Q53AQ4
canonical
genesymbol
Tmub1
resolver
genesymbol_syn
Hops
resolver
uniprot_entry
TMUB1_RAT
resolver
amino_acid_sequence
MALIEGVGDEVTVLFSVLACLLVLALAWVSTHTTESTDPLPQSSGTTTPAQPSEAMTAIDSIREEAPGAESPSLRHRGPSAQPEPEAGVTASTPPDSPQEPLLLRLKFLNDSEQVARAWPQDTIGSLKRTQFPGREQQVRLIYQGQLLGDDTQTLGSLHLPPNCVLHCHVSTRVGPPHPPCPPGSEPGPSGLEIGSLLLPLLLLLLLLLWYCQIQYRPFFPLTATLGLAGFTLLLSLLAFAMYRP
uniprot
proteins
function
FUNCTION: Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (By similarity). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (PubMed:18665261). Acts as a negative regulator of hepatocyte growth during regeneration (PubMed:22426572). {ECO:0000250|UniProtKB:Q9BVT8, ECO:0000250|UniProtKB:Q9JMG3, ECO:0000269|PubMed:18665261, ECO:0000269|PubMed:22426572}.; FUNCTION: [iHOPS]: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity). {ECO:0000250|UniProtKB:Q9JMG3}.
uniprot
proteins
mass_dalton
26349
uniprot
proteins
post_translational_modification
PTM: [iHOPS]: Processed by regulated intramembrane proteolysis (RIP) in the N-terminus to release iHOPS from membranes. {ECO:0000269|PubMed:24240191}.
uniprot
proteins
pubmed
16014383
uniprot
proteins
pubmed
18418082
uniprot
proteins
pubmed
18665261
uniprot
proteins
pubmed
22426572
uniprot
proteins
pubmed
22890319
uniprot
proteins
pubmed
24240191
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:24240191, ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9JMG3}. Recycling endosome {ECO:0000269|PubMed:18665261}. Cytoplasm {ECO:0000269|PubMed:16014383, ECO:0000269|PubMed:22426572}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18418082}. Nucleus {ECO:0000269|PubMed:16014383}. Nucleus, nucleolus {ECO:0000269|PubMed:22890319}. Note=Localized to neuronal soma and dendrites (PubMed:18665261). {ECO:0000269|PubMed:18665261}.; SUBCELLULAR LOCATION: [iHOPS]: Cytoplasm {ECO:0000250|UniProtKB:Q9JMG3, ECO:0000269|PubMed:24240191}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus {ECO:0000250|UniProtKB:Q9JMG3}. Note=iHOPS is proposed to be the shuttling form across different cellular compartments (By similarity). XPO1-dependent exported from the nucleus in dividing cells. Predominantly nuclear during growth arrest (PubMed:16014383). {ECO:0000250|UniProtKB:Q9JMG3, ECO:0000269|PubMed:16014383}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 194..214; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins