Ido1
entrez
66029
canonical
uniprot
Q9ERD9
canonical
ensembl
ENSRNOG00000031189
resolver
ensp
ENSRNOP00000050320
resolver
genesymbol
Ido1
resolver
genesymbol_syn
Ido
resolver
genesymbol_syn
Indo
resolver
uniprot_entry
I23O1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activity is inhibited by and MTH-trp (methylthiohydantoin-DL-tryptophan), modestly inhibited by L-1MT (1-methyl-L-tryptophan) but not D-1MT (1-methyl-D-tryptophan). {ECO:0000250|UniProtKB:P14902}.
uniprot
proteins
amino_acid_sequence
MPHSQISPAEGSRRILEEYHIDEDVGFALPHPLEELPDTYRPWILVARNLPKLIENGKLREEVEKLPTLRTEELRGHRLQRLAHLALGYITMAYVWNRGDDDIRKVLPRNLAVPYCELSEKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLMVEIAASPAIKAIPTVSSAVEHQDPKALEKALCSIAASLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKGNPKLPEGLLYEGVWDTPKKFSGGSAGQSSIFQSLDVLLGIKHDVGEGSAAEFLQEMREYMPPAHRNFLSSLESAPPVREFVILRRNEDLKEAYNECVNGLVSLRMFHLSIVDTYIVKPSKQKPMGGHKSEEPSNTENRGTGGTDVMNFLRSVKDTTKKALLSWP
uniprot
proteins
ec_number
1.13.11.52
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection. {ECO:0000250|UniProtKB:P14902}.
uniprot
proteins
mass_dalton
45831
uniprot
proteins
protein_family
3-dioxygenase family
uniprot
proteins
protein_family
Indoleamine 2
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P28776}.
uniprot
proteins