Rnf216
entrez
108086
canonical
uniprot
P58283
canonical
ensembl
ENSMUSG00000045078
resolver
ensp
ENSMUSP00000052563
resolver
ensp
ENSMUSP00000143705
resolver
ensp
ENSMUSP00000194277
resolver
ensp
ENSMUSP00000194278
resolver
ensp
ENSMUSP00000194279
resolver
ensp
ENSMUSP00000194283
resolver
ensp
ENSMUSP00000194290
resolver
genesymbol
Rnf216
resolver
genesymbol_syn
Triad3
resolver
genesymbol_syn
Ubce7ip1
resolver
genesymbol_syn
Uip83
resolver
genesymbol_syn
Zin
resolver
uniprot
Q3U493
resolver
uniprot
Q3UE56
resolver
uniprot
Q3UGM3
resolver
uniprot
Q68FN0
resolver
uniprot
Q6P1H8
resolver
uniprot
Q6PWY5
resolver
uniprot
Q8BN27
resolver
uniprot
Q8C1U3
resolver
uniprot_entry
RN216_MOUSE
resolver
uniprot_sec
Q3U493
resolver
uniprot_sec
Q3UE56
resolver
uniprot_sec
Q3UGM3
resolver
uniprot_sec
Q68FN0
resolver
uniprot_sec
Q6P1H8
resolver
uniprot_sec
Q6PWY5
resolver
uniprot_sec
Q8BN27
resolver
uniprot_sec
Q8C1U3
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by 'Lys-63'-linked di-ubiquitin. {ECO:0000250|UniProtKB:Q9NWF9}.
uniprot
proteins
amino_acid_sequence
MAEGNNKEEVIHLNNFPCHRGKEWMAVREGPITISDSSDEEGIPMLVTPATEQQEDDLDDDVILTEDDSEDEYGGFLDLESGKKEGEAKPGPSSKQTADDIVNPRLEQKVIILGENGLLFPESEPLEVQNQSSEDSETELLSNPGEPAASVDDQLIGEEYWLDHPYFQAPNPQPQERTNQVVPQERHSESEMGPMFFRHDFPEPAFPRPEPQQEGIPGPASPQPAHPLGELEDQQLAIDEDPGPAFPLSGPQEANLANMWEQEAAEVDQDLIPLLVKETEARFPDVASGYVEEIIHLKNYYDLNVLCNFLLENPDYPKREDRLIIHPSSSLLASQDDAKLPKIDFFDYSKLTPLDQRCFIQAADLLMADFKMLSSQDIKWALHELKGHYAITRKAFSDAIKKWQELSPETSGKRKKRKEMNQYSFIDFKFEQGNIKIEKRMFFLENKRRHCRYYDHQALLPAVKQEQEFYEQKIKEMAEHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEELTQCADAHLFCKECLIRYAQEAVFGSGKSELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPNPRCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSINGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEEEQKRKNGENTFKRIGPPLEKPAEKVQRVEALPRPVPQNLHPQMPPYAFVHPPFPLPPVRPVFNNFPINMGPVPAPYVPPLPNVRVNYDFGHMHVPLEHNLPMHFGPQPRHRF
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their ubiquitination. Plays a role in the regulation of antiviral responses by promoting the degradation of TRAF3, TLR4 and TLR9. In turn, down-regulates NF-kappa-B and IRF3 activation as well as beta interferon production. Also participates in the regulation of autophagy by ubiquitinating BECN1 leading to its degradation and autophagy inhibition. Plays a role in ARC-dependent synaptic plasticity by mediating ARC ubiquitination resulting in its rapid proteasomal degradation (By similarity). Plays aso an essential role in spermatogenesis and male fertility (PubMed:30649198). Mechanistically, regulates meiosis by promoting the degradation of PRKACB through the ubiquitin-mediated lysosome pathway (PubMed:33724554). Modulates the gonadotropin-releasing hormone signal pathway by affecting the stability of STAU2 that is required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite (PubMed:37439148). {ECO:0000250|UniProtKB:Q9NWF9, ECO:0000269|PubMed:30649198, ECO:0000269|PubMed:33724554, ECO:0000269|PubMed:37439148}.
uniprot
proteins
mass_dalton
97682
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000250|UniProtKB:Q9NWF9}.; PTM: Phosphorylation at Ser-719 enhances acceptor ubiquitin binding and chain-type specificity towards 'Lys-63' di-ubiquitin but not di-ubiquitin with other linkage types. {ECO:0000250|UniProtKB:Q9NWF9}.
uniprot
proteins
pubmed
10431818
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30649198
uniprot
proteins
pubmed
33724554
uniprot
proteins
pubmed
37439148
uniprot
proteins
sequence_length
853
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NWF9}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q9NWF9}.
uniprot
proteins