Irgq
entrez
210146
canonical
uniprot
Q8VIM9
canonical
ensembl
ENSMUSG00000041037
resolver
ensp
ENSMUSP00000036699
resolver
enst
ENSMUST00000049020
resolver
genesymbol
Irgq
resolver
genesymbol_syn
Irgq1
resolver
uniprot
Q7TNC7
resolver
uniprot_entry
IRGQ_MOUSE
resolver
uniprot_sec
Q7TNC7
resolver
amino_acid_sequence
MPLPQGDVTALFLGPPGSGKSALIAALCGKNVDTVEIPDGRQDSGVPSLRAAAPGLFLGELSCPPAAPGPWAAEANLLVLVLPGSEGSEEPLTPALGEAARAALARGTPLLAVRNLRPGDSQNAAKARDETAALLNSAGLGAAPLFVPPADCSSSDRCEELERLQVVLRTQAEALQRLLPPAQDGFEVLGAAELEAVREAFETGGLEAALSWVRAGLERLGSARLDLAVAGTTNVGLVLDMLLGLDPGDPGAAPASAPTGPTPYPAPERPNVVLWTVPLGPTATSPAVTPHPTHYDALILVTPGAPTEENWAQVRSLVSPDAPLVGVRTDGQGEDPPEVLEEEKAQNASDGNSGDARSEGKKAGIGDSGCTAARSPEDELWEVLEEAPPPVFPMRPGGLPGLGTWLQHALPTAQAGALLLALPPASPRAARRKAAALRAGAWRPALLASLAAAAAPVPGLGWACDVALLRGQLAEWRRALGLEPAAVARRERALGLAPGVLATRTRFPGPVTRAEVEARLGSWAGEGTAGGAALSALSFLWPTGGAAATGGLGYRAAHGVLLQALDEMLADAEAVLGPPEPNQ
uniprot
proteins
function
FUNCTION: Autophagy receptor that specifically promotes clearance of misfolded MHC class I molecules by targeting them to the lysosome for degradation (By similarity). Acts as a molecular adapter that specifically recognizes and binds (1) misfolded MHC class I molecules following their ubiquitination, as well as (2) autophagy-related proteins, promoting the recruitment of misfolded MHC class I molecules to autophagy machinery for degradation (By similarity). Degradation of misfolded MHC class I molecules is essential to prevent accumulation of defective MHC class I complexes at the surface of CD8(+) T-cells and prevent a stronger T-cell-mediated response (PubMed:39481378). In contrast to other members of the family, does not show GTPase activity (By similarity). {ECO:0000250|UniProtKB:Q8WZA9, ECO:0000269|PubMed:39481378}.
uniprot
proteins
mass_dalton
59323
uniprot
proteins
protein_family
IRG family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
39481378
uniprot
proteins
sequence_length
583
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q8WZA9}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q8WZA9}.
uniprot
proteins