ERGIC3
entrez
51614
canonical
uniprot
Q9Y282
canonical
ensembl
ENSG00000125991
resolver
ensp
ENSP00000341358
resolver
ensp
ENSP00000349970
resolver
genesymbol
ERGIC3
resolver
genesymbol_syn
C20orf47
resolver
genesymbol_syn
ERV46
resolver
genesymbol_syn
SDBCAG84
resolver
hgnc
HGNC:15927
resolver
uniprot
A2TJK5
resolver
uniprot
Q5JWS3
resolver
uniprot
Q6ZWP7
resolver
uniprot
Q9H276
resolver
uniprot
Q9P1L3
resolver
uniprot_entry
A2TJK5_HUMAN
resolver
uniprot_entry
ERGI3_HUMAN
resolver
uniprot_sec
Q5JWS3
resolver
uniprot_sec
Q6ZWP7
resolver
uniprot_sec
Q9H276
resolver
uniprot_sec
Q9P1L3
resolver
amino_acid_sequence
MEALGKLKQFDAYPKTLEDFRVKTCGGATVTIVSGLLMLLLFLSELQYYLTTEVHPELYVDKSRGDKLKINIDVLFPHMPCAYLSIDAMDVAGEQQLDVEHNLFKQRLDKDGIPVSSEAERHELGKVEVTVFDPDSLDPDRCESCYGAEAEDIKCCNTCEDVREAYRRRGWAFKNPDTIEQCRREGFSQKMQEQKNEGCQVYGFLEVNKVAGNFHFAPGKSFQQSHVHVHDLQSFGLDNINMTHYIQHLSFGEDYPGIVNPLDHTNVTAPQASMMFQYFVKVVPTVYMKVDGEVLRTNQFSVTRHEKVANGLLGDQGLPGVFVLYELSPMMVKLTEKHRSFTHFLTGVCAIIGGMFTVAGLIDSLIYHSARAIQKKIDLGKTT
uniprot
proteins
function
FUNCTION: Possible role in transport between endoplasmic reticulum and Golgi. Positively regulates trafficking of the secretory proteins SERPINA1/alpha1-antitrypsin and HP/haptoglobin (PubMed:31142615). {ECO:0000269|PubMed:31142615}.
uniprot
proteins
mass_dalton
43222
uniprot
proteins
mutagenesis
MUTAGEN 1..25; /note="Missing: Abolishes MARCHF2-mediated degradation."; /evidence="ECO:0000269|PubMed:31142615"; MUTAGEN 6; /note="K->R: Reduces MARCHF2-mediated ubiquitination and degradation. No effect on interaction with MARCHF2. Reduces MARCHF2-mediated ubiquitination and degradation by 90%; when associated with R-8."; /evidence="ECO:0000269|PubMed:31142615"; MUTAGEN 8; /note="K->R: Reduces MARCHF2-mediated ubiquitination and degradation. No effect on interaction with MARCHF2. Reduces MARCHF2-mediated ubiquitination and degradation by 90%; when associated with R-8."; /evidence="ECO:0000269|PubMed:31142615"; MUTAGEN 15; /note="K->R: No effect on MARCHF2-mediated ubiquitination and degradation."; /evidence="ECO:0000269|PubMed:31142615"; MUTAGEN 23; /note="K->R: No effect on MARCHF2-mediated ubiquitination and degradation."; /evidence="ECO:0000269|PubMed:31142615
uniprot
proteins
protein_family
ERGIC family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12747765
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15308636
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
31142615
uniprot
proteins
sequence_length
383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:15308636}; Multi-pass membrane protein {ECO:0000269|PubMed:15308636}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:15308636}; Multi-pass membrane protein {ECO:0000269|PubMed:15308636}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15308636}; Multi-pass membrane protein {ECO:0000269|PubMed:15308636}. Note=Cycles between the endoplasmic reticulum and the Golgi.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 342..362; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins