ITGA3
entrez
3675
canonical
uniprot
P26006
canonical
ensembl
ENSG00000005884
resolver
ensp
ENSP00000315190
resolver
genesymbol
ITGA3
resolver
genesymbol_syn
MSK18
resolver
hgnc
HGNC:6139
resolver
uniprot
A0A140VJM0
resolver
uniprot
A7E246
resolver
uniprot
B7ZM80
resolver
uniprot
B9EGQ1
resolver
uniprot
D3DTX4
resolver
uniprot
D3DTX5
resolver
uniprot_entry
A0A140VJM0_HUMAN
resolver
uniprot_entry
ITA3_HUMAN
resolver
uniprot_sec
A7E246
resolver
uniprot_sec
B7ZM80
resolver
uniprot_sec
B9EGQ1
resolver
uniprot_sec
D3DTX4
resolver
uniprot_sec
D3DTX5
resolver
amino_acid_sequence
MGPGPSRAPRAPRLMLCALALMVAAGGCVVSAFNLDTRFLVVKEAGNPGSLFGYSVALHRQTERQQRYLLLAGAPRELAVPDGYTNRTGAVYLCPLTAHKDDCERMNITVKNDPGHHIIEDMWLGVTVASQGPAGRVLVCAHRYTQVLWSGSEDQRRMVGKCYVRGNDLELDSSDDWQTYHNEMCNSNTDYLETGMCQLGTSGGFTQNTVYFGAPGAYNWKGNSYMIQRKEWDLSEYSYKDPEDQGNLYIGYTMQVGSFILHPKNITIVTGAPRHRHMGAVFLLSQEAGGDLRRRQVLEGSQVGAYFGSAIALADLNNDGWQDLLVGAPYYFERKEEVGGAIYVFMNQAGTSFPAHPSLLLHGPSGSAFGLSVASIGDINQDGFQDIAVGAPFEGLGKVYIYHSSSKGLLRQPQQVIHGEKLGLPGLATFGYSLSGQMDVDENFYPDLLVGSLSDHIVLLRARPVINIVHKTLVPRPAVLDPALCTATSCVQVELCFAYNQSAGNPNYRRNITLAYTLEADRDRRPPRLRFAGSESAVFHGFFSMPEMRCQKLELLLMDNLRDKLRPIIISMNYSLPLRMPDRPRLGLRSLDAYPILNQAQALENHTEVQFQKECGPDNKCESNLQMRAAFVSEQQQKLSRLQYSRDVRKLLLSINVTNTRTSERSGEDAHEALLTLVVPPALLLSSVRPPGACQANETIFCELGNPFKRNQRMELLIAFEVIGVTLHTRDLQVQLQLSTSSHQDNLWPMILTLLVDYTLQTSLSMVNHRLQSFFGGTVMGESGMKTVEDVGSPLKYEFQVGPMGEGLVGLGTLVLGLEWPYEVSNGKWLLYPTEITVHGNGSWPCRPPGDLINPLNLTLSDPGDRPSSPQRRRRQLDPGGGQGPPPVTLAAAKKAKSETVLTCATGRAHCVWLECPIPDAPVVTNVTVKARVWNSTFIEDYRDFDRVRVNGWATLFLRTSIPTINMENKTTWFSVDIDSELVEELPAEIELWLVLVAVGAGLLLLGLIILLLWKCGFFKRARTRALYEAKRQKAEMKSQPSETERLTDDY
uniprot
proteins
disease_involvement
DISEASE: Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome (JEB7) [MIM:614748]: A form of epidermolysis bullosa, a genodermatosis characterized by recurrent blistering, fragility of the skin and mucosal epithelia, and erosions caused by minor mechanical trauma. JEB7 is an autosomal recessive form associated with congenital nephrotic syndrome and interstitial lung disease. The respiratory and renal features predominate, and lung involvement accounts for the lethal course of the disease. {ECO:0000269|PubMed:22512483, ECO:0000269|PubMed:27717396}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. {ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:15181153}.; FUNCTION: (Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression. {ECO:0000269|PubMed:32487760}.
uniprot
proteins
mass_dalton
116612
uniprot
proteins
mutagenesis
MUTAGEN 1016; /note="C->S: Abolishes palmitoylation."; /evidence="ECO:0000269|PubMed:15611341
uniprot
proteins
post_translational_modification
PTM: Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation. {ECO:0000269|PubMed:9111516}.
uniprot
proteins
protein_family
Integrin alpha chain family
uniprot
proteins
pubmed
10455171
uniprot
proteins
pubmed
14596610
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15181153
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15611341
uniprot
proteins
pubmed
1655803
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
1714443
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22512483
uniprot
proteins
pubmed
27717396
uniprot
proteins
pubmed
3033641
uniprot
proteins
pubmed
32487760
uniprot
proteins
pubmed
8187758
uniprot
proteins
pubmed
9111516
uniprot
proteins
sequence_length
1051
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15611341, ECO:0000269|PubMed:32487760}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:15611341}; Lipid-anchor {ECO:0000269|PubMed:15611341}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, filopodium membrane {ECO:0000269|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Note=Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. {ECO:0000269|PubMed:10455171}.
uniprot
proteins
transmembrane_region
TRANSMEM 992..1014; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins