HLA-DQB1
entrez
3119
canonical
uniprot
P01920
canonical
ensembl
ENSG00000179344
resolver
ensembl
ENSG00000206237
resolver
ensembl
ENSG00000206302
resolver
ensembl
ENSG00000225824
resolver
ensembl
ENSG00000231286
resolver
ensembl
ENSG00000233209
resolver
ensp
ENSP00000364080
resolver
ensp
ENSP00000372602
resolver
ensp
ENSP00000372734
resolver
ensp
ENSP00000382034
resolver
ensp
ENSP00000382038
resolver
ensp
ENSP00000396539
resolver
ensp
ENSP00000402865
resolver
ensp
ENSP00000407332
resolver
ensp
ENSP00000410107
resolver
ensp
ENSP00000410330
resolver
ensp
ENSP00000414079
resolver
enst
ENST00000374943
resolver
enst
ENST00000383121
resolver
enst
ENST00000383247
resolver
enst
ENST00000399084
resolver
enst
ENST00000399088
resolver
enst
ENST00000413089
resolver
enst
ENST00000416192
resolver
enst
ENST00000419914
resolver
enst
ENST00000422950
resolver
enst
ENST00000424806
resolver
enst
ENST00000434651
resolver
genesymbol
HLA-DQB1
resolver
genesymbol_syn
HLA-DQB
resolver
hgnc
HGNC:4944
resolver
uniprot
A0A182DWF1
resolver
uniprot
A1KR27
resolver
uniprot
A2RPH3
resolver
uniprot
A4Q9R4
resolver
uniprot
A4USG2
resolver
uniprot
A4USG5
resolver
uniprot
A6N8I7
resolver
uniprot
A9YQA0
resolver
uniprot
B0S7Y7
resolver
uniprot
B1A0K6
resolver
uniprot
B1GXI3
resolver
uniprot
B3VLT3
resolver
uniprot
B5BLN7
resolver
uniprot
B7VU69
resolver
uniprot
C0MQ34
resolver
uniprot
C0MQ35
resolver
uniprot
C8ZL52
resolver
uniprot
C8ZLJ8
resolver
uniprot
C8ZLJ9
resolver
uniprot
C9DRQ3
resolver
uniprot
F6WSC5
resolver
uniprot
O19708
resolver
uniprot
O19713
resolver
uniprot
O19724
resolver
uniprot
O62861
resolver
uniprot
O78046
resolver
uniprot
O78221
resolver
uniprot
O78223
resolver
uniprot
O98034
resolver
uniprot
O98201
resolver
uniprot
P01917
resolver
uniprot
P01918
resolver
uniprot
P01919
resolver
uniprot
P03992
resolver
uniprot
P05537
resolver
uniprot
P79482
resolver
uniprot
P79526
resolver
uniprot
P79544
resolver
uniprot
P79551
resolver
uniprot
Q08GC8
resolver
uniprot
Q09035
resolver
uniprot
Q0E4V9
resolver
uniprot
Q1M312
resolver
uniprot
Q29731
resolver
uniprot
Q29877
resolver
uniprot
Q29884
resolver
uniprot
Q29915
resolver
uniprot
Q29966
resolver
uniprot
Q2P9N3
resolver
uniprot
Q2QK85
resolver
uniprot
Q30061
resolver
uniprot
Q30075
resolver
uniprot
Q30076
resolver
uniprot
Q30080
resolver
uniprot
Q30081
resolver
uniprot
Q30082
resolver
uniprot
Q30083
resolver
uniprot
Q30084
resolver
uniprot
Q30089
resolver
uniprot
Q30095
resolver
uniprot
Q31633
resolver
uniprot
Q38I47
resolver
uniprot
Q45UE3
resolver
uniprot
Q4QZB5
resolver
uniprot
Q53I44
resolver
uniprot
Q564J6
resolver
uniprot
Q5G841
resolver
uniprot
Q5ISH1
resolver
uniprot
Q5ISH3
resolver
uniprot
Q5SU54
resolver
uniprot
Q5W1E1
resolver
uniprot
Q5Y7A9
resolver
uniprot
Q5Y7D3
resolver
uniprot
Q5Y7D6
resolver
uniprot
Q5Y7G8
resolver
uniprot
Q643R4
resolver
uniprot
Q6B9X1
resolver
uniprot
Q70VH8
resolver
uniprot
Q7YP69
resolver
uniprot
Q8HWH0
resolver
uniprot
Q8MH58
resolver
uniprot
Q8SNB4
resolver
uniprot
Q8SND1
resolver
uniprot
Q8SP70
resolver
uniprot
Q8WMA3
resolver
uniprot
Q9BD17
resolver
uniprot
Q9MYH2
resolver
uniprot
Q9TPA9
resolver
uniprot
Q9XRY6
resolver
uniprot
Q9XRY7
resolver
uniprot
Q9XRZ2
resolver
uniprot
U3Q031
resolver
uniprot_entry
A0A182DWF1_HUMAN
resolver
uniprot_entry
DQB1_HUMAN
resolver
uniprot_entry
F6WSC5_HUMAN
resolver
uniprot_entry
Q5SU54_HUMAN
resolver
uniprot_entry
Q5Y7A9_HUMAN
resolver
uniprot_entry
Q5Y7D3_HUMAN
resolver
uniprot_entry
Q5Y7D6_HUMAN
resolver
uniprot_sec
A1KR27
resolver
uniprot_sec
A2RPH3
resolver
uniprot_sec
A4Q9R4
resolver
uniprot_sec
A4USG2
resolver
uniprot_sec
A4USG5
resolver
uniprot_sec
A6N8I7
resolver
uniprot_sec
A9YQA0
resolver
uniprot_sec
B0S7Y7
resolver
uniprot_sec
B1A0K6
resolver
uniprot_sec
B1GXI3
resolver
uniprot_sec
B3VLT3
resolver
uniprot_sec
B5BLN7
resolver
uniprot_sec
B7VU69
resolver
uniprot_sec
C0MQ34
resolver
uniprot_sec
C0MQ35
resolver
uniprot_sec
C8ZL52
resolver
uniprot_sec
C8ZLJ8
resolver
uniprot_sec
C8ZLJ9
resolver
uniprot_sec
C9DRQ3
resolver
uniprot_sec
O19708
resolver
uniprot_sec
O19713
resolver
uniprot_sec
O19724
resolver
uniprot_sec
O62861
resolver
uniprot_sec
O78046
resolver
uniprot_sec
O78221
resolver
uniprot_sec
O78223
resolver
uniprot_sec
O98034
resolver
uniprot_sec
O98201
resolver
uniprot_sec
P01917
resolver
uniprot_sec
P01918
resolver
uniprot_sec
P01919
resolver
uniprot_sec
P03992
resolver
uniprot_sec
P05537
resolver
uniprot_sec
P79482
resolver
uniprot_sec
P79526
resolver
uniprot_sec
P79544
resolver
uniprot_sec
P79551
resolver
uniprot_sec
Q08GC8
resolver
uniprot_sec
Q09035
resolver
uniprot_sec
Q0E4V9
resolver
uniprot_sec
Q1M312
resolver
uniprot_sec
Q29731
resolver
uniprot_sec
Q29877
resolver
uniprot_sec
Q29884
resolver
uniprot_sec
Q29915
resolver
uniprot_sec
Q29966
resolver
uniprot_sec
Q2P9N3
resolver
uniprot_sec
Q2QK85
resolver
uniprot_sec
Q30061
resolver
uniprot_sec
Q30075
resolver
uniprot_sec
Q30076
resolver
uniprot_sec
Q30080
resolver
uniprot_sec
Q30081
resolver
uniprot_sec
Q30082
resolver
uniprot_sec
Q30083
resolver
uniprot_sec
Q30084
resolver
uniprot_sec
Q30089
resolver
uniprot_sec
Q30095
resolver
uniprot_sec
Q31633
resolver
uniprot_sec
Q38I47
resolver
uniprot_sec
Q45UE3
resolver
uniprot_sec
Q4QZB5
resolver
uniprot_sec
Q53I44
resolver
uniprot_sec
Q564J6
resolver
uniprot_sec
Q5G841
resolver
uniprot_sec
Q5ISH1
resolver
uniprot_sec
Q5ISH3
resolver
uniprot_sec
Q5W1E1
resolver
uniprot_sec
Q5Y7G8
resolver
uniprot_sec
Q643R4
resolver
uniprot_sec
Q6B9X1
resolver
uniprot_sec
Q70VH8
resolver
uniprot_sec
Q7YP69
resolver
uniprot_sec
Q8HWH0
resolver
uniprot_sec
Q8MH58
resolver
uniprot_sec
Q8SNB4
resolver
uniprot_sec
Q8SND1
resolver
uniprot_sec
Q8SP70
resolver
uniprot_sec
Q8WMA3
resolver
uniprot_sec
Q9BD17
resolver
uniprot_sec
Q9MYH2
resolver
uniprot_sec
Q9TPA9
resolver
uniprot_sec
Q9XRY6
resolver
uniprot_sec
Q9XRY7
resolver
uniprot_sec
Q9XRZ2
resolver
uniprot_sec
U3Q031
resolver
amino_acid_sequence
MSWKKALRIPGGLRAATVTLMLAMLSTPVAEGRDSPEDFVYQFKAMCYFTNGTERVRYVTRYIYNREEYARFDSDVEVYRAVTPLGPPDAEYWNSQKEVLERTRAELDTVCRHNYQLELRTTLQRRVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRNDQEETTGVVSTPLIRNGDWTFQILVMLEMTPQHGDVYTCHVEHPSLQNPITVEWRAQSESAQSKMLSGIGGFVLGLIFLGLGLIIHHRSQKGLLH
uniprot
proteins
function
FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
uniprot
proteins
mass_dalton
29991
uniprot
proteins
protein_family
MHC class II family
uniprot
proteins
pubmed
10323344
uniprot
proteins
pubmed
11098940
uniprot
proteins
pubmed
11376336
uniprot
proteins
pubmed
11684289
uniprot
proteins
pubmed
11782280
uniprot
proteins
pubmed
1440562
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14769912
uniprot
proteins
pubmed
15020763
uniprot
proteins
pubmed
15361133
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15853909
uniprot
proteins
pubmed
16140993
uniprot
proteins
pubmed
16441489
uniprot
proteins
pubmed
17212715
uniprot
proteins
pubmed
17241953
uniprot
proteins
pubmed
17559588
uniprot
proteins
pubmed
17629515
uniprot
proteins
pubmed
17868257
uniprot
proteins
pubmed
17999653
uniprot
proteins
pubmed
18046453
uniprot
proteins
pubmed
18331527
uniprot
proteins
pubmed
18565458
uniprot
proteins
pubmed
18588576
uniprot
proteins
pubmed
19092054
uniprot
proteins
pubmed
19254265
uniprot
proteins
pubmed
19392794
uniprot
proteins
pubmed
19493242
uniprot
proteins
pubmed
19533806
uniprot
proteins
pubmed
2010218
uniprot
proteins
pubmed
2050393
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2212675
uniprot
proteins
pubmed
2308943
uniprot
proteins
pubmed
2494138
uniprot
proteins
pubmed
2777341
uniprot
proteins
pubmed
2886427
uniprot
proteins
pubmed
2888727
uniprot
proteins
pubmed
2925231
uniprot
proteins
pubmed
2998758
uniprot
proteins
pubmed
3020127
uniprot
proteins
pubmed
3036828
uniprot
proteins
pubmed
3259543
uniprot
proteins
pubmed
3584986
uniprot
proteins
pubmed
6206493
uniprot
proteins
pubmed
6316358
uniprot
proteins
pubmed
6415003
uniprot
proteins
pubmed
6576979
uniprot
proteins
pubmed
6952552
uniprot
proteins
pubmed
6954511
uniprot
proteins
pubmed
7928445
uniprot
proteins
pubmed
8598037
uniprot
proteins
pubmed
8896171
uniprot
proteins
pubmed
8896183
uniprot
proteins
pubmed
8929711
uniprot
proteins
pubmed
8988541
uniprot
proteins
pubmed
8988543
uniprot
proteins
pubmed
9174147
uniprot
proteins
pubmed
9271631
uniprot
proteins
pubmed
9458130
uniprot
proteins
pubmed
9802612
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
uniprot
proteins
transmembrane_region
TRANSMEM 231..251; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins