GNPDA2
entrez
132789
canonical
uniprot
Q8TDQ7
canonical
ensembl
ENSG00000163281
resolver
ensp
ENSP00000295448
resolver
ensp
ENSP00000425868
resolver
ensp
ENSP00000427423
resolver
genesymbol
GNPDA2
resolver
genesymbol_syn
GNP2
resolver
hgnc
HGNC:21526
resolver
uniprot
B4DJF3
resolver
uniprot
Q2VYF1
resolver
uniprot
Q59EA7
resolver
uniprot
Q8NCZ8
resolver
uniprot
Q96BJ4
resolver
uniprot
Q96NC6
resolver
uniprot_entry
GNPI2_HUMAN
resolver
uniprot_sec
B4DJF3
resolver
uniprot_sec
Q2VYF1
resolver
uniprot_sec
Q59EA7
resolver
uniprot_sec
Q8NCZ8
resolver
uniprot_sec
Q96BJ4
resolver
uniprot_sec
Q96NC6
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by N-acetylglucosamine-6-phosphate (GlcNAc6P). {ECO:0000269|PubMed:12616532}.
uniprot
proteins
amino_acid_sequence
MRLVILDNYDLASEWAAKYICNRIIQFKPGQDRYFTLGLPTGSTPLGCYKKLIEYHKNGHLSFKYVKTFNMDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCDEDATLELRVKTVKYFKGLMHVHNKLVDPLFSMKDGN
uniprot
proteins
ec_number
3.5.99.6
uniprot
proteins
function
FUNCTION: Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. {ECO:0000269|PubMed:12616532, ECO:0000269|PubMed:26887390}.
uniprot
proteins
mass_dalton
31085
uniprot
proteins
pathway_participation
PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1. {ECO:0000305|PubMed:26887390}.
uniprot
proteins
protein_family
Glucosamine/galactosamine-6-phosphate isomerase family
uniprot
proteins
pubmed
12616532
uniprot
proteins
pubmed
12965206
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
26887390
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins