Limk1
entrez
16885
canonical
uniprot
P53668
canonical
ensembl
ENSMUSG00000029674
resolver
ensp
ENSMUSP00000015137
resolver
ensp
ENSMUSP00000106864
resolver
enst
ENSMUST00000015137
resolver
enst
ENSMUST00000111233
resolver
genesymbol
Limk1
resolver
genesymbol_syn
Limk
resolver
uniprot
E9PVB6
resolver
uniprot
Q3UR47
resolver
uniprot_entry
E9PVB6_MOUSE
resolver
uniprot_entry
LIMK1_MOUSE
resolver
uniprot_entry
Q3UR47_MOUSE
resolver
amino_acid_sequence
MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCECSVSLSHQYYEKDGQLFCKKDYWARYGESCHGCSEHITKGLVMVAGELKYHPECFICLACGNFIGDGDTYTLVEHSKLYCGQCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASAHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDSLGHGPVSDPSPLSSPVHTPSGQAASSARQKPVLRSCSIDTSPGTSSLASPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKNMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKNQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEQWLETLRMHLSGHLPLGPQLEQLERGFWETYRRGESSLPAHPEVPD
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:15056216, PubMed:16204183). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:15056216). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development (By similarity). {ECO:0000250|UniProtKB:P53667, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:16204183}.
uniprot
proteins
mass_dalton
72793
uniprot
proteins
mutagenesis
MUTAGEN 460; /note="D->G: Abrogates kinase activity."; /evidence="ECO:0000269|PubMed:15056216
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Phosphorylated on Thr-508 by ROCK1 and PAK1, resulting in activation. Phosphorylated by PAK4 which increases the ability of LIMK1 to phosphorylate cofilin. Phosphorylated at Ser-323 by MAPKAPK2 during activation of VEGFA-induced signaling, which results in activation of LIMK1 and promotion of actin reorganization, cell migration, and tubule formation of endothelial cells. Dephosphorylated and inactivated by SSH1. Phosphorylated by CDC42BP (By similarity). {ECO:0000250|UniProtKB:P53667}.; PTM: Ubiquitinated. 'Lys-48'-linked polyubiquitination by RNF6 leads to proteasomal degradation through the 26S proteasome, modulating LIMK1 levels in the growth cone and its effect on axonal outgrowth. Also polyubiquitinated by RLIM. {ECO:0000269|PubMed:16204183}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
11003705
uniprot
proteins
pubmed
15056216
uniprot
proteins
pubmed
15660133
uniprot
proteins
pubmed
16204183
uniprot
proteins
pubmed
18332102
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25107909
uniprot
proteins
pubmed
7478547
uniprot
proteins
pubmed
7848918
uniprot
proteins
pubmed
8541208
uniprot
proteins
sequence_length
647
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16204183}. Nucleus {ECO:0000250|UniProtKB:P53667}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P53667}. Cell projection, lamellipodium {ECO:0000269|PubMed:25107909}. Note=Predominantly found in the cytoplasm (By similarity). Localizes in the lamellipodium in a CDC42BPA, CDC42BPB and FAM89B/LRAP25-dependent manner. {ECO:0000269|PubMed:25107909}.
uniprot
proteins