Tmem35a
entrez
308134
canonical
uniprot
Q6JAM9
canonical
ensembl
ENSRNOG00000001506
resolver
ensembl
ENSRNOG00055014136
resolver
ensembl
ENSRNOG00060021106
resolver
ensembl
ENSRNOG00065006288
resolver
ensp
ENSRNOP00000002058
resolver
ensp
ENSRNOP00055019834
resolver
ensp
ENSRNOP00060030072
resolver
ensp
ENSRNOP00065006946
resolver
enst
ENSRNOT00000002058
resolver
enst
ENSRNOT00055024284
resolver
enst
ENSRNOT00060036540
resolver
enst
ENSRNOT00065009638
resolver
genesymbol
Tmem35a
resolver
genesymbol_syn
Nacho
resolver
genesymbol_syn
Tmem35
resolver
genesymbol_syn
Tuf1
resolver
uniprot_entry
NACHO_RAT
resolver
amino_acid_sequence
MASPRTITIVALSVALGLFFVFMGTIKLTPRLSKDAYSEMKRAYKSYVRALPLLKKMGINSILLRKSIGALEVACGIVMTLVPGRPKDVANFFLLLLVLAVLFFHQLVGDPLKRYAHALVFGILLTCRLLIARKPEDRSSEKKALPESAEEQPSLYEKAPQGKVKVS
uniprot
proteins
function
FUNCTION: Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (PubMed:26875622). Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (PubMed:26875622). Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (PubMed:26875622). Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (By similarity). {ECO:0000250|UniProtKB:Q53FP2, ECO:0000250|UniProtKB:Q9D328, ECO:0000269|PubMed:26875622}.
uniprot
proteins
mass_dalton
18473
uniprot
proteins
mutagenesis
MUTAGEN 46; /note="S->A: Abolishes interaction with NGFR."; /evidence="ECO:0000269|PubMed:20685870
uniprot
proteins
protein_family
DoxX family
uniprot
proteins
pubmed
20685870
uniprot
proteins
pubmed
26875622
uniprot
proteins
pubmed
28131622
uniprot
proteins
sequence_length
167
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250|UniProtKB:Q9D328}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle {ECO:0000269|PubMed:20685870}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:26875622}; Multi-pass membrane protein {ECO:0000255}. Note=Shedding may lead to a soluble peptide. {ECO:0000269|PubMed:20685870}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 89..109; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 115..132; /note="Helical; Name=4"; /evidence="ECO:0000255
uniprot
proteins