RMND5A
entrez
64795
canonical
uniprot
Q9H871
canonical
ensembl
ENSG00000153561
resolver
ensp
ENSP00000283632
resolver
genesymbol
RMND5A
resolver
hgnc
HGNC:25850
resolver
uniprot
D6W5M6
resolver
uniprot
Q6NTF0
resolver
uniprot
Q9H6W5
resolver
uniprot
Q9H9H2
resolver
uniprot_entry
RMD5A_HUMAN
resolver
uniprot_sec
D6W5M6
resolver
uniprot_sec
Q6NTF0
resolver
uniprot_sec
Q9H6W5
resolver
uniprot_sec
Q9H9H2
resolver
amino_acid_sequence
MDQCVTVERELEKVLHKFSGYGQLCERGLEELIDYTGGLKHEILQSHGQDAELSGTLSLVLTQCCKRIKDTVQKLASDHKDIHSSVSRVGKAIDKNFDSDISSVGIDGCWQADSQRLLNEVMVEHFFRQGMLDVAEELCQESGLSVDPSQKEPFVELNRILEALKVRVLRPALEWAVSNREMLIAQNSSLEFKLHRLYFISLLMGGTTNQREALQYAKNFQPFALNHQKDIQVLMGSLVYLRQGIENSPYVHLLDANQWADICDIFTRDACALLGLSVESPLSVSFSAGCVALPALINIKAVIEQRQCTGVWNQKDELPIEVDLGKKCWYHSIFACPILRQQTTDNNPPMKLVCGHIISRDALNKMFNGSKLKCPYCPMEQSPGDAKQIFF
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). {ECO:0000269|PubMed:29911972}.
uniprot
proteins
mass_dalton
43993
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17467196
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24143168
uniprot
proteins
pubmed
25793641
uniprot
proteins
pubmed
29911972
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:24143168, ECO:0000269|PubMed:25793641}. Cytoplasm {ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:24143168, ECO:0000269|PubMed:25793641}.
uniprot
proteins