Scp2
entrez
20280
canonical
uniprot
P32020
canonical
ensembl
ENSMUSG00000028603
resolver
ensp
ENSMUSP00000030340
resolver
genesymbol
Scp2
resolver
genesymbol_syn
Scp-2
resolver
uniprot
A2APS2
resolver
uniprot
A2APS3
resolver
uniprot
Q9DBM7
resolver
uniprot_entry
SCP2_MOUSE
resolver
uniprot_sec
A2APS2
resolver
uniprot_sec
A2APS3
resolver
uniprot_sec
Q9DBM7
resolver
amino_acid_sequence
MPSVALKSPRLRRVFVVGVGMTKFMKPGGENSRDYPDMAKEAGQKALEDAQIPYSAVEQACVGYVYGDSTSGQRAIYHSLGLTGIPIINVNNNCSTGSTALFMAHQLIQGGLANCVLALGFEKMERGSIGTKFSDRTTPTDKHIEVLIDKYGLSAHPITPQMFGYAGKEHMEKYGTKVEHFAKIGWKNHKHSVNNTYSQFQDEYSLEEVMKSKPVFDFLTILQCCPTSDGAAAAILSSEEFVQQYGLQSKAVEIVAQEMMTDLPSTFEEKSIIKVVGYDMSKEAARRCYEKSGLTPNDVDVIELHDCFSVNELITYEALGLCPEGQGGTLVDRGDNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQVPGAKVALQHNLGLGGAVVVTLYRMGFPEAASSFRTHQVSAAPTSSAGDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDLLALMTGKMNPQSAFFQGKLKIAGNMGLAMKLQNLQLQPGKAKL
uniprot
proteins
ec_number
2.3.1.155
uniprot
proteins
ec_number
2.3.1.16
uniprot
proteins
ec_number
2.3.1.176
uniprot
proteins
function
FUNCTION: [Isoform SCPx]: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids (PubMed:10706581). Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (PubMed:10706581). Also active with medium and long straight chain 3-oxoacyl-CoAs (By similarity). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (PubMed:9553048). {ECO:0000250|UniProtKB:P11915, ECO:0000269|PubMed:10706581, ECO:0000269|PubMed:9553048}.; FUNCTION: [Isoform SCP2]: Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis (By similarity). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (By similarity). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA (PubMed:9553048). Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides (PubMed:11003606). Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3 (PubMed:11003606). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (PubMed:9553048). {ECO:0000250|UniProtKB:P11915, ECO:0000250|UniProtKB:P22307, ECO:0000269|PubMed:11003606, ECO:0000269|PubMed:9553048}.
uniprot
proteins
mass_dalton
59126
uniprot
proteins
post_translational_modification
PTM: [Isoform SCP2]: preSCP2, a protein with a molecular mass of about 15 kDa, is processed into its mature form (SCP2) by proteolytic cleavage of a 20 residue leader sequence after translocation into peroxisomes. {ECO:0000250|UniProtKB:O62742}.
uniprot
proteins
protein_family
Thiolase family
uniprot
proteins
protein_family
Thiolase-like superfamily
uniprot
proteins
pubmed
10706581
uniprot
proteins
pubmed
11003606
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16916647
uniprot
proteins
pubmed
1709640
uniprot
proteins
pubmed
17208939
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
26901662
uniprot
proteins
pubmed
8428655
uniprot
proteins
pubmed
8751375
uniprot
proteins
pubmed
9553048
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform SCP2]: Cytoplasm {ECO:0000269|PubMed:11003606, ECO:0000269|PubMed:26901662}. Peroxisome {ECO:0000269|PubMed:11003606, ECO:0000269|PubMed:26901662}. Endoplasmic reticulum {ECO:0000269|PubMed:11003606}. Mitochondrion {ECO:0000269|PubMed:11003606, ECO:0000269|PubMed:26901662}.; SUBCELLULAR LOCATION: [Isoform SCPx]: Peroxisome {ECO:0000269|PubMed:26901662}.
uniprot
proteins