Shoc2
entrez
56392
canonical
uniprot
O88520
canonical
ensembl
ENSMUSG00000024976
resolver
ensp
ENSMUSP00000025932
resolver
ensp
ENSMUSP00000127932
resolver
ensp
ENSMUSP00000261541
resolver
ensp
ENSMUSP00000261542
resolver
ensp
ENSMUSP00000261546
resolver
ensp
ENSMUSP00000351249
resolver
enst
ENSMUST00000025932
resolver
enst
ENSMUST00000169861
resolver
genesymbol
Shoc2
resolver
uniprot
Q3UJH6
resolver
uniprot
Q8BVL0
resolver
uniprot
Q91VH8
resolver
uniprot_entry
SHOC2_MOUSE
resolver
uniprot_sec
Q3UJH6
resolver
uniprot_sec
Q8BVL0
resolver
uniprot_sec
Q91VH8
resolver
amino_acid_sequence
MSSSLGKEKDSKEKDPKVPSAKEREKESKASGGFGKESKEKEPKAKGKDAKDGKKESSAAQPGVAFSVDNTIKRPNPAPGTRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPPSVKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLPKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNDLLDLPDTIGNLSSLNRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLSTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPSFIIQFLKMQGPYRAMV
uniprot
proteins
function
FUNCTION: Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway (By similarity). Acts as a scaffolding protein in the SMP complex (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity). Acts as an inhibitor of keratinocyte differentiation via interaction with RAS protein complexes that promote ERK activation (By similarity). {ECO:0000250|UniProtKB:Q9UQ13}.
uniprot
proteins
mass_dalton
64893
uniprot
proteins
protein_family
SHOC2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16682971
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9674433
uniprot
proteins
sequence_length
582
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UQ13}. Nucleus {ECO:0000250|UniProtKB:Q9UQ13}. Note=Translocates from cytoplasm to nucleus upon growth factor stimulation. {ECO:0000250|UniProtKB:Q9UQ13}.
uniprot
proteins