Lat
entrez
16797
canonical
uniprot
O54957
canonical
ensembl
ENSMUSG00000030742
resolver
ensp
ENSMUSP00000032997
resolver
ensp
ENSMUSP00000145773
resolver
ensp
ENSMUSP00000348247
resolver
enst
ENSMUST00000032997
resolver
enst
ENSMUST00000206793
resolver
genesymbol
Lat
resolver
uniprot
A0A0U1RP03
resolver
uniprot
Q546H1
resolver
uniprot_entry
A0A0U1RP03_MOUSE
resolver
uniprot_entry
LAT_MOUSE
resolver
uniprot_entry
Q546H1_MOUSE
resolver
amino_acid_sequence
MEADALSPVGLGLLLLPFLVTLLAALCVRCRELPVSYDSTSTESLYPRSILIKPPQITVPRTPAVSYPLVTSFPPLRQPDLLPIPRSPQPLGGSHRMPSSQQNSDDANSVASYENQEPACKNVDADEDEDDYPNGYLVVLPDSSPAAVPVVSSAPVPSNPDLGDSAFSVESCEDYVNVPESEESAEASLDGSREYVNVSPEQQPVTRAELASVNSQEVEDEGEEEGVDGEEAPDYENLQELN
uniprot
proteins
function
FUNCTION: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10843385}.
uniprot
proteins
mass_dalton
26015
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes (By similarity). {ECO:0000250}.; PTM: Palmitoylation of Cys-27 and Cys-30 is required for raft targeting and efficient phosphorylation. {ECO:0000250}.; PTM: Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes. {ECO:0000250|UniProtKB:O43561}.; PTM: 'Lys-63'-linked ubiquitinated by TRAF6. {ECO:0000250|UniProtKB:O43561}.
uniprot
proteins
pubmed
10843385
uniprot
proteins
pubmed
11463797
uniprot
proteins
pubmed
12626544
uniprot
proteins
pubmed
14696041
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19592663
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22561606
uniprot
proteins
pubmed
22732588
uniprot
proteins
pubmed
9489702
uniprot
proteins
sequence_length
242
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.
uniprot
proteins
transmembrane_region
TRANSMEM 5..28; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins