RCE1
entrez
9986
canonical
uniprot
Q9Y256
canonical
ensembl
ENSG00000173653
resolver
ensp
ENSP00000309163
resolver
ensp
ENSP00000435409
resolver
enst
ENST00000309657
resolver
genesymbol
RCE1
resolver
genesymbol_syn
FACE2
resolver
genesymbol_syn
RCE1A
resolver
genesymbol_syn
RCE1B
resolver
hgnc
HGNC:13721
resolver
uniprot
Q0P5W4
resolver
uniprot
Q52LZ9
resolver
uniprot_entry
FACE2_HUMAN
resolver
uniprot_entry
Q0P5W4_HUMAN
resolver
uniprot_sec
Q52LZ9
resolver
activity_regulation
ACTIVITY REGULATION: Deubiquitination by USP17L2/USP17 negatively regulates the proteolytic activity toward Ras GTPases. {ECO:0000269|PubMed:19188362}.
uniprot
proteins
amino_acid_sequence
MAALGGDGLRLLSVSRPERPPESAALGGLGPGLCCWVSVFSCLSLACSYVGSLYVWKSELPRDHPAVIKRRFTSVLVVSSLSPLCVLLWRELTGIQPGTSLLTLMGFRLEGIFPAALLPLLLTMILFLGPLMQLSMDCPCDLADGLKVVLAPRSWARCLTDMRWLRNQVIAPLTEELVFRACMLPMLAPCMGLGPAVFTCPLFFGVAHFHHIIEQLRFRQSSVGNIFLSAAFQFSYTAVFGAYTAFLFIRTGHLIGPVLCHSFCNYMGFPAVCAALEHPQRRPLLAGYALGVGLFLLLLQPLTDPKLYGSLPLCVLLERAGDSEAPLCS
uniprot
proteins
ec_number
3.4.26.1
uniprot
proteins
function
FUNCTION: Protease involved in the processing of a variety of prenylated proteins containing the C-terminal CAAX motif, where C is a cysteine modified with an isoprenoid lipid, A is an aliphatic amino acid and X is any C-terminal amino acid. Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins, leaving the prenylated cysteine as the new C-terminus. Is able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068). {ECO:0000269|PubMed:10085068, ECO:0000269|PubMed:11038283, ECO:0000269|PubMed:19188362}.
uniprot
proteins
mass_dalton
35833
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Undergoes 'Lys-48'- and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains. {ECO:0000269|PubMed:19188362}.
uniprot
proteins
protein_family
Peptidase U48 family
uniprot
proteins
pubmed
10085068
uniprot
proteins
pubmed
10373325
uniprot
proteins
pubmed
11038283
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19188362
uniprot
proteins
pubmed
22814378
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19188362}; Multi-pass membrane protein {ECO:0000269|PubMed:19188362}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 75..95; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 229..249; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 254..274; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 283..303; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins