Enpp7
entrez
238011
canonical
uniprot
Q3TIW9
canonical
ensembl
ENSMUSG00000046697
resolver
ensp
ENSMUSP00000101880
resolver
enst
ENSMUST00000106273
resolver
genesymbol
Enpp7
resolver
uniprot
A2A5N7
resolver
uniprot
D3Z6V6
resolver
uniprot_entry
ENPP7_MOUSE
resolver
uniprot_sec
A2A5N7
resolver
uniprot_sec
D3Z6V6
resolver
amino_acid_sequence
MGHSAVLLCVALAILPACVTGAPVQRQHKLLLVSFDGFRWNYDQDVDTPNLDSMAQEGVKAQYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMFYNTTSTVRLPYHATLGIQRWWDNGSIPIWITAQRQGLKTGSFFYPGGNVTYQGEAVTMSRKEGVLHNYKNETEWRGNVDTVMKWFLEEDVSLVTLYFGEPDSTGHKYGPESQERKDMVKQVDRTVGYLRDSIKRHHLSDSLNLIITSDHGMTTVNKKASDLVEFHKFSNFTFQDIQFELLDYGPIGMLIPKEGMLEKVYSVLKDAHPRLHVYKKEDFPKNFHYANNPRITPLLMYSDLGYVIHGRVNVQFNNGEHGFNNQDMDMKTIFRAVGPSFKAGLEVEPFESVHVYELMCQLLGIVPEPNDGNPGILRPMLRSGSASLLSSQHHLVALLVGILTCLAKVL
uniprot
proteins
ec_number
3.1.4.12
uniprot
proteins
function
FUNCTION: Choline-specific phosphodiesterase that hydrolyzes sphingomyelin releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract (PubMed:21177474). Also has phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation. Does not have nucleotide pyrophosphatase activity (By similarity). May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen (PubMed:24650549). {ECO:0000250|UniProtKB:Q6UWV6, ECO:0000269|PubMed:21177474, ECO:0000269|PubMed:24650549}.
uniprot
proteins
mass_dalton
49618
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; required for activity and transport to the plasma membrane. {ECO:0000250|UniProtKB:Q6UWV6}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21177474
uniprot
proteins
pubmed
24650549
uniprot
proteins
sequence_length
439
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6UWV6}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q6UWV6}. Note=The catalytic domain is released into the extracellular medium when cells are treated with trypsin. Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex. {ECO:0000250|UniProtKB:Q6UWV6}.
uniprot
proteins
transmembrane_region
TRANSMEM 415..435; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins