TBC1D10C
entrez
374403
canonical
uniprot
Q8IV04
canonical
ensembl
ENSG00000175463
resolver
ensp
ENSP00000310193
resolver
ensp
ENSP00000435543
resolver
ensp
ENSP00000443654
resolver
ensp
ENSP00000538990
resolver
ensp
ENSP00000538991
resolver
ensp
ENSP00000538992
resolver
ensp
ENSP00000538993
resolver
ensp
ENSP00000616071
resolver
ensp
ENSP00000660526
resolver
genesymbol
TBC1D10C
resolver
hgnc
HGNC:24702
resolver
uniprot
G3V1D6
resolver
uniprot_entry
TB10C_HUMAN
resolver
uniprot_sec
G3V1D6
resolver
amino_acid_sequence
MAQALGEDLVQPPELQDDSSSLGSDSELSGPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSERDLQREIKAQLAQLPDSAPGPPPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVPRIVVQPPEEPRPPRRKPQTRGKTFHGLLTRARGPPIEGPPRPQRGSTSFLDTRF
uniprot
proteins
function
FUNCTION: Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras. {ECO:0000269|PubMed:17230191}.
uniprot
proteins
mass_dalton
49712
uniprot
proteins
mutagenesis
MUTAGEN 141; /note="R->A: Loss of GAP activity."; /evidence="ECO:0000269|PubMed:17230191
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17230191
uniprot
proteins
pubmed
19690332
uniprot
proteins
sequence_length
446
uniprot
proteins