Eif5a
entrez
287444
canonical
uniprot
Q3T1J1
canonical
ensembl
ENSRNOG00055030897
resolver
ensembl
ENSRNOG00060030866
resolver
ensembl
ENSRNOG00065027407
resolver
ensp
ENSRNOP00055044331
resolver
ensp
ENSRNOP00060044513
resolver
ensp
ENSRNOP00065038750
resolver
enst
ENSRNOT00055053607
resolver
enst
ENSRNOT00060053619
resolver
enst
ENSRNOT00065047259
resolver
genesymbol
Eif5a
resolver
uniprot_entry
IF5A1_RAT
resolver
amino_acid_sequence
MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK
uniprot
proteins
function
FUNCTION: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Also regulates TNF-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival (By similarity). May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (PubMed:18606156, PubMed:19006180). Is required for autophagy by assisting the ribosome in translating the ATG3 protein at a specific amino acid sequence, the 'ASP-ASP-Gly' motif, leading to the increase of the efficiency of ATG3 translation and facilitation of LC3B lipidation and autophagosome formation (By similarity). {ECO:0000250|UniProtKB:P23301, ECO:0000250|UniProtKB:P63241, ECO:0000269|PubMed:18606156, ECO:0000269|PubMed:19006180}.
uniprot
proteins
mass_dalton
16832
uniprot
proteins
post_translational_modification
PTM: Acetylated by PCAF/KAT2B, regulating its subcellular localization (By similarity). Deacetylated by SIRT2 (By similarity). {ECO:0000250|UniProtKB:P63241}.; PTM: Lys-50 undergoes hypusination, a unique post-translational modification that consists in the addition of a butylamino group from spermidine to lysine side chain, leading to the formation of the unusual amino acid hypusine. eIF-5As are the only known proteins to undergo this modification, which is essential for their function. {ECO:0000250|UniProtKB:P63241}.
uniprot
proteins
protein_family
EIF-5A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18606156
uniprot
proteins
pubmed
19006180
uniprot
proteins
sequence_length
154
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P63241}. Nucleus {ECO:0000250|UniProtKB:P63241}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P63241}; Peripheral membrane protein {ECO:0000250|UniProtKB:P63241}; Cytoplasmic side {ECO:0000250|UniProtKB:P63241}. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. Nuclear export of hypusinated protein is mediated by XPO4. {ECO:0000250|UniProtKB:P63241}.
uniprot
proteins