Drc9
entrez
363796
canonical
uniprot
Q5PQQ6
canonical
ensembl
ENSRNOG00000026420
resolver
ensp
ENSRNOP00000037862
resolver
ensp
ENSRNOP00000071586
resolver
enst
ENSRNOT00000032518
resolver
genesymbol
Drc9
resolver
genesymbol_syn
Iqcg
resolver
uniprot
G3V973
resolver
uniprot_entry
DRC9_RAT
resolver
uniprot_entry
G3V973_RAT
resolver
amino_acid_sequence
MEGEELETTGSLSEVFQPEVTMAVTGEPPKPAEEELEEEEEETSPEVIDTLSLLDVLRVSAIMEDIIDQLSILGYIIPVQYERRQSLSQKTSHEGAPMVPSTPKISASLIAKDKPVVSDSKQRGQDFFFKKATKQTTMTLETMRKIQNDRQYFSDVIANAMMEMQACGSFSSLLEALGKERDAKMNFHDVITREGKGRKQIKSLQKQLVDVKRERQMQVQNGNEYIAHLRDQLQEVKAKTNLENLYMKRNTELQVSQTQKKCNRAEELLLEEIEKLRLKTEEENRVHMEIEMFLRNQQQKLEEKLEFWMEKFDKDTEAKQNELNALKAAKASDLAHLQDLAKMIREYEQVIIEDRLEKEKTRKKLEQDDLELRSIVKLQAWWRGTVVRREIGSFKMPKKEKDDSKDAKGKEKDKRRGKK
uniprot
proteins
function
FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility. {ECO:0000250|UniProtKB:A3KQH2, ECO:0000250|UniProtKB:A8HQ54, ECO:0000250|UniProtKB:Q80W32}.
uniprot
proteins
mass_dalton
48757
uniprot
proteins
protein_family
DRC9 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q80W32}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q80W32}. Cell projection, cilium {ECO:0000250|UniProtKB:Q80W32}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q80W32}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8HQ54}. Note=First detected in the cytoplasm of pachytene spermatocytes. Colocalizes with alpha-tubulin at the manchette in developing spermatids. Detected in the flagellum of mature testicular spermatozoa, and in the flagellum and post-acrosomal region of the head of epididymal spermatozoa. Detected in cilia in trachea and oviduct. {ECO:0000250|UniProtKB:Q80W32}.
uniprot
proteins