SLC16A10
entrez
117247
canonical
uniprot
Q8TF71
canonical
ensembl
ENSG00000112394
resolver
ensp
ENSP00000357844
resolver
ensp
ENSP00000725196
resolver
ensp
ENSP00000790325
resolver
enst
ENST00000368851
resolver
genesymbol
SLC16A10
resolver
genesymbol_syn
MCT10
resolver
genesymbol_syn
TAT1
resolver
hgnc
HGNC:17027
resolver
uniprot
B3KWY0
resolver
uniprot
Q6ZMG0
resolver
uniprot
Q8WVI5
resolver
uniprot_entry
MOT10_HUMAN
resolver
uniprot_sec
B3KWY0
resolver
uniprot_sec
Q6ZMG0
resolver
uniprot_sec
Q8WVI5
resolver
amino_acid_sequence
MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVELAGPATAEPHEPPEPPEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFIPWIHSKKQREISKTTGKEKMEKMLENQNSLLSSSSGMFKKESDSII
uniprot
proteins
function
FUNCTION: Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed:18337592). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:11827462, PubMed:28754537). Plays an important role in homeostasis of aromatic amino acids (By similarity). {ECO:0000250|UniProtKB:Q3U9N9, ECO:0000269|PubMed:11827462, ECO:0000269|PubMed:18337592, ECO:0000269|PubMed:28754537}.
uniprot
proteins
mass_dalton
55493
uniprot
proteins
mutagenesis
MUTAGEN 81; /note="N->K: Does not affect subcellular localization. Abolishes tryptophan import activity."; /evidence="ECO:0000269|PubMed:28754537
uniprot
proteins
post_translational_modification
PTM: Not N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
11827462
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18337592
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28754537
uniprot
proteins
sequence_length
515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11827462, ECO:0000269|PubMed:18337592, ECO:0000269|PubMed:28754537}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q91Y77}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 67..87; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 145..165; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 229..249; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 292..312; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 330..350; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 352..372; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 397..417; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 420..440; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 452..472; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins