GRPEL2
entrez
134266
canonical
uniprot
Q8TAA5
canonical
ensembl
ENSG00000164284
resolver
ensp
ENSP00000329558
resolver
genesymbol
GRPEL2
resolver
hgnc
HGNC:21060
resolver
uniprot
B4DFA6
resolver
uniprot
Q49AJ6
resolver
uniprot_entry
GRPE2_HUMAN
resolver
uniprot_sec
B4DFA6
resolver
uniprot_sec
Q49AJ6
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform 1]: Activated by oxidative stress, which induces the formation of reversible disulfide-linked homodimers likely through a conserved cysteine residue (Cys-87). {ECO:0000269|PubMed:30098457}.
uniprot
proteins
amino_acid_sequence
MAVRSLWAGRLRVQRLLAWSAAWESKGWPLPFSTATQRTAGEDCRSEDPPDELGPPLAERALRVKAVKLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTECISEESEPEDQKLTLEKVFRGLLLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGVGVQPGTVALVRQDGYKLHGRTIRLARVEVAVESQRRL
uniprot
proteins
function
FUNCTION: [Isoform 1]: Nucleotide exchange factor (NEF) for mitochondrial HSP70 (mt-HSP70/HSPA9), facilitating the release of ADP from HSPA9 to allow ATP rebinding, which is essential for the chaperone cycle (PubMed:28848044). Functions as a component of the presequence translocase-associated motor (PAM) complex, which drives ATP-dependent import of proteins into the mitochondrial matrix (PubMed:28848044). In the PAM complex, supports the HSPA9-driven pulling mechanism that translocates polypeptides through the TIM23 complex (PubMed:28848044). Functions as a redox-regulated component of the mitochondrial protein import and folding machinery, with its activity modulated by oxidative stress (PubMed:30098457). May control the nucleotide-dependent binding of HSPA9 to substrate proteins (By similarity). {ECO:0000250|UniProtKB:Q9HAV7, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30098457}.; FUNCTION: [Isoform 2]: NERCLIN functions as a negative regulator of cardiolipin homeostasis and mitochondrial ultrastructure, contributing to the stress-induced adaptation of mitochondrial dynamics. Responds to heat stress by ensuring OPA1 processing and cell survival (PubMed:37463214). Lacks nucleotide exchange factor (NEF) activity (PubMed:37463214). This isoform is specifically expressed in human and some non-human primates (PubMed:37463214). {ECO:0000269|PubMed:37463214}.
uniprot
proteins
mass_dalton
25431
uniprot
proteins
mutagenesis
MUTAGEN 87; /note="C->A: Loss of oxidative stress-induced homodimerirazion."; /evidence="ECO:0000269|PubMed:30098457"; MUTAGEN 97; /note="C->A: No change in oxidative stress-induced homodimerirazion."; /evidence="ECO:0000269|PubMed:30098457
uniprot
proteins
protein_family
GrpE family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28848044
uniprot
proteins
pubmed
30098457
uniprot
proteins
pubmed
37463214
uniprot
proteins
sequence_length
225
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion matrix {ECO:0000269|PubMed:30098457}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion matrix {ECO:0000269|PubMed:37463214}.
uniprot
proteins