LRRC8E
entrez
80131
canonical
uniprot
Q6NSJ5
canonical
ensembl
ENSG00000171017
resolver
ensp
ENSP00000306524
resolver
ensp
ENSP00000479953
resolver
ensp
ENSP00000577415
resolver
ensp
ENSP00000590486
resolver
ensp
ENSP00000626276
resolver
ensp
ENSP00000626277
resolver
enst
ENST00000306708
resolver
enst
ENST00000618098
resolver
enst
ENST00000907356
resolver
enst
ENST00000920427
resolver
enst
ENST00000956217
resolver
enst
ENST00000956218
resolver
genesymbol
LRRC8E
resolver
hgnc
HGNC:26272
resolver
uniprot
B3KR78
resolver
uniprot
Q2YDY3
resolver
uniprot
Q7L236
resolver
uniprot
Q8N3B0
resolver
uniprot
Q9H5H8
resolver
uniprot_entry
LRC8E_HUMAN
resolver
uniprot_sec
B3KR78
resolver
uniprot_sec
Q2YDY3
resolver
uniprot_sec
Q7L236
resolver
uniprot_sec
Q8N3B0
resolver
uniprot_sec
Q9H5H8
resolver
amino_acid_sequence
MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPNHELQENLSEAPCQQLLPRGIPEQIGALQEVKGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENQKGPAATERAAATIVAMAGTGPGKAGEGEKEKVLAEPEKVVTEPPVVTLLDKKEGEQAKALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVETSEVTGYASFCCNHTKAHLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVREETGMGDIPDVKNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKLQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLPAEVRDKMEEE
uniprot
proteins
function
FUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (PubMed:33139539). {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731, ECO:0000269|PubMed:33139539, ECO:0000269|PubMed:33171122}.
uniprot
proteins
mass_dalton
90247
uniprot
proteins
mutagenesis
MUTAGEN 44; /note="T->C: Alters channel anion selectivity."; /evidence="ECO:0000269|PubMed:26824658
uniprot
proteins
protein_family
LRRC8 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
22532330
uniprot
proteins
pubmed
24790029
uniprot
proteins
pubmed
26824658
uniprot
proteins
pubmed
28193731
uniprot
proteins
pubmed
33139539
uniprot
proteins
pubmed
33171122
uniprot
proteins
sequence_length
796
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:24790029}. Lysosome membrane {ECO:0000269|PubMed:33139539}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:33139539}; Multi-pass membrane protein {ECO:0000305}. Note=In the absence of LRRC8A, resides primarily in the endoplasmic reticulum (PubMed:24790029, PubMed:33139539). Requires LRRC8A for localization at the cell membrane or lysosome membrane (PubMed:24790029, PubMed:33139539). {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:33139539}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 266..286; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 314..334; /note="Helical; Name=4"; /evidence="ECO:0000255
uniprot
proteins