Nuak1
entrez
77976
canonical
uniprot
Q641K5
canonical
ensembl
ENSMUSG00000020032
resolver
ensp
ENSMUSP00000020220
resolver
enst
ENSMUST00000020220
resolver
genesymbol
Nuak1
resolver
genesymbol_syn
Kiaa0537
resolver
genesymbol_syn
Omphk1
resolver
uniprot
Q6I6D6
resolver
uniprot
Q8CGE1
resolver
uniprot_entry
NUAK1_MOUSE
resolver
uniprot_sec
Q6I6D6
resolver
uniprot_sec
Q8CGE1
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-212. Activated by phosphorylation at Ser-601 AKT1 during glucose starvation; the relevance of such activation in normal cells is however unsure (By similarity). {ECO:0000250|UniProtKB:O60285}.
uniprot
proteins
amino_acid_sequence
MEGAAVSAAGDGPAVETGLPGSPLEAVAGATAAPVEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLIYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALPDSESPLLARIIDWHHRSTGLQAEAEAKMKGLAKPGASEVVLERQRSLKKSKKENDFPQSGQDSVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGIVSPALPSPFKMEQDLCRTAIPLPSSPEADMSGKLSLKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVVISGGLSSPPPDPARGTSHSLSCRRKGILKHSSRYSDGGTDPALTRPEMPTLESLSPPGVPSDGISRSYSRPSSIISDDSVLSSDSFDLLELQENRPARQRIRSCVSAENFLQLQDFETPHNRPRPQYLKRLADSSFSLLTDMDDVTQVYKKALEICSKLN
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair. {ECO:0000250|UniProtKB:O60285}.
uniprot
proteins
mass_dalton
73661
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-212 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not dephosphorylated by the myosin PP1 complex when regulating its activity, due to the presence of PPP1R12A, which prevents myosin PP1 from dephosphorylating NUAK1. Phosphorylated by STK38L upon stimulation with IGF1 (By similarity). {ECO:0000250|UniProtKB:O60285}.; PTM: Ubiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X (By similarity). {ECO:0000250|UniProtKB:O60285}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SNF1 subfamily
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16715502
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
658
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O60285}. Cytoplasm {ECO:0000250|UniProtKB:O60285}.
uniprot
proteins