Rps6
entrez
29304
canonical
uniprot
P62755
canonical
ensembl
ENSRNOG00000049025
resolver
ensembl
ENSRNOG00055016993
resolver
ensembl
ENSRNOG00060013788
resolver
ensembl
ENSRNOG00065019153
resolver
ensp
ENSRNOP00000067572
resolver
ensp
ENSRNOP00055023236
resolver
ensp
ENSRNOP00060018711
resolver
ensp
ENSRNOP00065025718
resolver
enst
ENSRNOT00000073270
resolver
enst
ENSRNOT00055028877
resolver
enst
ENSRNOT00060023555
resolver
enst
ENSRNOT00065032209
resolver
genesymbol
Rps6
resolver
uniprot
P08227
resolver
uniprot
P10660
resolver
uniprot_entry
RS6_RAT
resolver
uniprot_sec
P08227
resolver
uniprot_sec
P10660
resolver
amino_acid_sequence
MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK
uniprot
proteins
function
FUNCTION: Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000250|UniProtKB:P62753}.
uniprot
proteins
mass_dalton
28681
uniprot
proteins
post_translational_modification
PTM: Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the pre-initiation complex. {ECO:0000250|UniProtKB:P62753}.; PTM: Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8. {ECO:0000250|UniProtKB:P62753}.; PTM: Mono-ADP-ribosylation at Glu-35 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation. {ECO:0000250|UniProtKB:P62753}.
uniprot
proteins
protein_family
Eukaryotic ribosomal protein eS6 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2106518
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
3277962
uniprot
proteins
pubmed
398910
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62753}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62753}.
uniprot
proteins