Klhdc2
entrez
299113
canonical
uniprot
Q3KRE6
canonical
ensembl
ENSRNOG00000004474
resolver
ensembl
ENSRNOG00055009150
resolver
ensembl
ENSRNOG00060005929
resolver
ensembl
ENSRNOG00065006617
resolver
ensp
ENSRNOP00000083418
resolver
ensp
ENSRNOP00000103688
resolver
ensp
ENSRNOP00055012396
resolver
ensp
ENSRNOP00060007346
resolver
ensp
ENSRNOP00065007462
resolver
enst
ENSRNOT00000113703
resolver
enst
ENSRNOT00000142020
resolver
enst
ENSRNOT00055015480
resolver
enst
ENSRNOT00060009805
resolver
enst
ENSRNOT00065010226
resolver
genesymbol
Klhdc2
resolver
genesymbol_syn
Klhdc2l1
resolver
uniprot
A0A8I6G908
resolver
uniprot_entry
A0A8I6G908_RAT
resolver
uniprot_entry
KLDC2_RAT
resolver
amino_acid_sequence
MADGNEDARAEDMPGPAFEGYEAMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSADRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFAWSQPITTGKAPSPRAAHACATVGNKGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTEKQPLSDAWTYCISKNEWIQFNHPYVEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEVLIFSVQPKSLVRLSLEAVICFKEMLANSWSCLPKHLLHSVNQRFGSNNTSGS
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(KLHDC2) complex specifically recognizes proteins with a diglycine (Gly-Gly) at the C-terminus, leading to their ubiquitination and degradation (By similarity). The CRL2(KLHDC2) complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine (By similarity). The CRL2(KLHDC2) complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation (By similarity). May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding (By similarity). {ECO:0000250|UniProtKB:Q9Y2U9}.
uniprot
proteins
mass_dalton
45926
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9Y2U9}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated by the CRL2(KLHDC2) E3 ligase complex. {ECO:0000250|UniProtKB:Q9Y2U9}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y2U9}.
uniprot
proteins