TRIM2
entrez
23321
canonical
uniprot
Q9C040
canonical
ensembl
ENSG00000109654
resolver
ensp
ENSP00000339659
resolver
ensp
ENSP00000415812
resolver
ensp
ENSP00000487750
resolver
ensp
ENSP00000501562
resolver
ensp
ENSP00000501612
resolver
ensp
ENSP00000501662
resolver
ensp
ENSP00000501672
resolver
ensp
ENSP00000501994
resolver
ensp
ENSP00000501997
resolver
ensp
ENSP00000502077
resolver
ensp
ENSP00000502083
resolver
ensp
ENSP00000502243
resolver
ensp
ENSP00000502266
resolver
ensp
ENSP00000502290
resolver
ensp
ENSP00000502331
resolver
ensp
ENSP00000502356
resolver
ensp
ENSP00000502492
resolver
ensp
ENSP00000502519
resolver
ensp
ENSP00000502541
resolver
ensp
ENSP00000502543
resolver
ensp
ENSP00000502676
resolver
ensp
ENSP00000502720
resolver
ensp
ENSP00000502775
resolver
ensp
ENSP00000502776
resolver
ensp
ENSP00000598412
resolver
ensp
ENSP00000660981
resolver
ensp
ENSP00000718807
resolver
ensp
ENSP00000746249
resolver
ensp
ENSP00000746250
resolver
enst
ENST00000482578
resolver
enst
ENST00000674726
resolver
enst
ENST00000674935
resolver
enst
ENST00000675710
resolver
enst
ENST00000675782
resolver
enst
ENST00000675899
resolver
enst
ENST00000676167
resolver
enst
ENST00000676335
resolver
enst
ENST00000676408
resolver
genesymbol
TRIM2
resolver
genesymbol_syn
KIAA0517
resolver
genesymbol_syn
RNF86
resolver
hgnc
HGNC:15974
resolver
uniprot
A0A0J9YW02
resolver
uniprot
A0A6Q8PF74
resolver
uniprot
A0A6Q8PG16
resolver
uniprot
A0A6Q8PGG4
resolver
uniprot
A0A6Q8PHP4
resolver
uniprot
D3DP09
resolver
uniprot
O60272
resolver
uniprot
Q9BSI9
resolver
uniprot
Q9UFZ1
resolver
uniprot_entry
A0A0J9YW02_HUMAN
resolver
uniprot_entry
A0A6Q8PF74_HUMAN
resolver
uniprot_entry
A0A6Q8PG16_HUMAN
resolver
uniprot_entry
A0A6Q8PGG4_HUMAN
resolver
uniprot_entry
A0A6Q8PHP4_HUMAN
resolver
uniprot_entry
TRIM2_HUMAN
resolver
uniprot_sec
D3DP09
resolver
uniprot_sec
O60272
resolver
uniprot_sec
Q9BSI9
resolver
uniprot_sec
Q9UFZ1
resolver
amino_acid_sequence
MASEGTNIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNAEESSILETVTAVAAGKPLSCPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQVQLDAVNKRLPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPRENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCKTGNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKLKVIRSADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKGRNKGEFTNLQGVAASTNGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSSDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ
uniprot
proteins
disease_involvement
DISEASE: Charcot-Marie-Tooth disease, axonal, type 2R (CMT2R) [MIM:615490]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. {ECO:0000269|PubMed:23562820}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738). {ECO:0000250|UniProtKB:Q9ESN6, ECO:0000269|PubMed:24068738}.
uniprot
proteins
mass_dalton
81530
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: RING-type zinc finger-dependent and UBE2D1-dependent autoubiquitination. {ECO:0000250|UniProtKB:Q9ESN6}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21478148
uniprot
proteins
pubmed
23562820
uniprot
proteins
pubmed
24068738
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
36481767
uniprot
proteins
pubmed
9628581
uniprot
proteins
sequence_length
744
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36481767}.
uniprot
proteins