Atoh7
entrez
53404
canonical
uniprot
Q9Z2E5
canonical
ensembl
ENSMUSG00000036816
resolver
ensp
ENSMUSP00000039801
resolver
enst
ENSMUST00000044059
resolver
genesymbol
Atoh7
resolver
genesymbol_syn
Ath5
resolver
uniprot_entry
ATOH7_MOUSE
resolver
amino_acid_sequence
MKSACKPHGPPAGARGAPPCAGAAERAVSCAGPGRLESAARRRLAANARERRRMQGLNTAFDRLRRVVPQWGQDKKLSKYETLQMALSYIIALTRILAEAERDWVGLRCEQRGRDHPYLPFPGARLQVDPEPYGQRLFGFQPEPFPMAS
uniprot
proteins
function
FUNCTION: Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (PubMed:33712461). Dimerization with TCF3 isoform E47 may be required in certain situations (By similarity). Binds to gene promoters and enhancer elements, and thereby regulates a transcriptional program of retinal ganglion cell (RGC) determinant genes (PubMed:33712461). Although the exact mechanism is not certain, retinal transcription regulation by ATOH7 has a role in RGC determination and survival, photoreceptor population development, targeting of RGC axons to the optic nerve and development of the retino-hypothalamic tract (PubMed:11156601, PubMed:11493566, PubMed:12451142, PubMed:33712461). Binds to its own promoter and enhancer sequences, suggesting autoregulation of ATOH7 transcription (PubMed:33712461). Required for retinal circadian rhythm photoentrainment (PubMed:12451142, PubMed:26392540). Plays a role in brainstem auditory signaling and binaural processing (PubMed:17977745). {ECO:0000250|UniProtKB:Q8N100, ECO:0000269|PubMed:11156601, ECO:0000269|PubMed:11493566, ECO:0000269|PubMed:12451142, ECO:0000269|PubMed:17977745, ECO:0000269|PubMed:26392540, ECO:0000269|PubMed:33712461}.
uniprot
proteins
mass_dalton
16569
uniprot
proteins
pubmed
11156601
uniprot
proteins
pubmed
11493566
uniprot
proteins
pubmed
11889557
uniprot
proteins
pubmed
12451142
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17977745
uniprot
proteins
pubmed
26392540
uniprot
proteins
pubmed
33712461
uniprot
proteins
pubmed
9806930
uniprot
proteins
sequence_length
149
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33712461}. Perikaryon {ECO:0000269|PubMed:17977745}. Cell projection, axon {ECO:0000269|PubMed:17977745}.
uniprot
proteins