BAD
entrez
572
canonical
uniprot
Q92934
canonical
ensembl
ENSG00000002330
resolver
ensp
ENSP00000309103
resolver
ensp
ENSP00000378040
resolver
ensp
ENSP00000523781
resolver
ensp
ENSP00000523782
resolver
ensp
ENSP00000523783
resolver
ensp
ENSP00000523784
resolver
ensp
ENSP00000523785
resolver
ensp
ENSP00000523787
resolver
ensp
ENSP00000523788
resolver
ensp
ENSP00000624692
resolver
ensp
ENSP00000624693
resolver
enst
ENST00000309032
resolver
enst
ENST00000394532
resolver
enst
ENST00000853722
resolver
enst
ENST00000853723
resolver
enst
ENST00000853724
resolver
enst
ENST00000853725
resolver
enst
ENST00000853726
resolver
enst
ENST00000853728
resolver
enst
ENST00000853729
resolver
enst
ENST00000954633
resolver
enst
ENST00000954634
resolver
genesymbol
BAD
resolver
genesymbol_syn
BBC6
resolver
genesymbol_syn
BCL2L8
resolver
hgnc
HGNC:936
resolver
uniprot
O14803
resolver
uniprot
Q6FH21
resolver
uniprot_entry
BAD_HUMAN
resolver
uniprot_sec
O14803
resolver
uniprot_sec
Q6FH21
resolver
amino_acid_sequence
MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSHHGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
uniprot
proteins
function
FUNCTION: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}.
uniprot
proteins
mass_dalton
18392
uniprot
proteins
mutagenesis
MUTAGEN 94; /note="R->K: Decreased methylation; when associated with K-96."; /evidence="ECO:0000269|PubMed:21444773"; MUTAGEN 96; /note="R->K: Decreased methylation; when associated with K-94."; /evidence="ECO:0000269|PubMed:21444773
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blocked by the apoptotic C-terminus cleavage product of PKN2 generated by caspases-3 activity during apoptosis. {ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:12897128, ECO:0000269|PubMed:16818649}.; PTM: Methylation at Arg-94 and Arg-96 by PRMT1 inhibits Akt-mediated phosphorylation at Ser-99. {ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:21444773}.
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
10926925
uniprot
proteins
pubmed
11206074
uniprot
proteins
pubmed
11278822
uniprot
proteins
pubmed
12897128
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16509771
uniprot
proteins
pubmed
16818649
uniprot
proteins
pubmed
17270021
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21444773
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8929532
uniprot
proteins
pubmed
9388232
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane. Cytoplasm {ECO:0000250|UniProtKB:Q61337}. Note=Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm. {ECO:0000250|UniProtKB:Q61337}.
uniprot
proteins