Klhl22
entrez
303792
canonical
uniprot
D3ZZC3
canonical
ensembl
ENSRNOG00000001878
resolver
ensembl
ENSRNOG00055003606
resolver
ensembl
ENSRNOG00060012995
resolver
ensembl
ENSRNOG00065008036
resolver
ensp
ENSRNOP00000063573
resolver
ensp
ENSRNOP00000112391
resolver
ensp
ENSRNOP00055004226
resolver
ensp
ENSRNOP00060017543
resolver
ensp
ENSRNOP00065009347
resolver
enst
ENSRNOT00000068711
resolver
enst
ENSRNOT00000166570
resolver
enst
ENSRNOT00055005647
resolver
enst
ENSRNOT00060022129
resolver
enst
ENSRNOT00065012693
resolver
genesymbol
Klhl22
resolver
uniprot
A0A8L2QUL2
resolver
uniprot
D4A9W5
resolver
uniprot_entry
A0A8L2QUL2_RAT
resolver
uniprot_entry
KLH22_RAT
resolver
uniprot_sec
D4A9W5
resolver
amino_acid_sequence
MAEEQDFAQLCKLSTQPSHSHCVNNTYRSTQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLNRLTQQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSMEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLGPSPLRDTVASALMYHRNESLQPSLQGPHTELRSDFQCVVGFGGIHSTPSTILSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLCVCVVGKYIYAVAGRDYHNNLSAVERYDPATNSWEYVAPLKKEVYAHAGTTLQGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMAALLDKLFVIGGSNNDAGYRRDVHQVACYSCTSRQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDMEKDCWEEGPQLNNSISGLAACVLTLPRSLLHEQPRGTPNRSQADADFASEVMSVSDWEEFDNSSED
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy. {ECO:0000250|UniProtKB:Q53GT1}.
uniprot
proteins
mass_dalton
71774
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q53GT1}.
uniprot
proteins
pubmed
16641100
uniprot
proteins
sequence_length
634
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q53GT1}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q53GT1}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q53GT1}. Nucleus {ECO:0000250|UniProtKB:Q53GT1}. Lysosome {ECO:0000250|UniProtKB:Q53GT1}. Note=Mainly cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Localizes to the centrosomes shortly before cells enter anaphase After anaphase onset, predominantly associates with the polar microtubules connecting the 2 opposing centrosomes and gradually diffuses into the cytoplasm during telophase. Localizes to the nucleus upon amino acid starvation. Relocalizes to the cytosol and associates with lysosomes when amino acids are available. {ECO:0000250|UniProtKB:Q53GT1}.
uniprot
proteins