Kcnc1
entrez
25327
canonical
uniprot
P25122
canonical
ensembl
ENSRNOG00000055401
resolver
ensembl
ENSRNOG00055006842
resolver
ensembl
ENSRNOG00060011256
resolver
ensembl
ENSRNOG00065008751
resolver
ensp
ENSRNOP00000074146
resolver
genesymbol
Kcnc1
resolver
uniprot_entry
KCNC1_RAT
resolver
amino_acid_sequence
MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRADSKLNGEVAKAALANEDCPHIDQALTPDEGLPFTRSGTRERYGPCFLLSTGEYACPPGGGMRKDLCKESPVIAKYMPTEAVRVT
uniprot
proteins
function
FUNCTION: Voltage-gated potassium channel that opens in response to the voltage difference across the membrane and through which potassium ions pass in accordance with their electrochemical gradient (Probable) (PubMed:10482766, PubMed:1378392, PubMed:14679187). The mechanism is time-dependent and inactivation is slow (PubMed:10482766, PubMed:1378392). Plays an important role in the rapid repolarization of fast-firing brain neurons (PubMed:10482766). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well (PubMed:10482766, PubMed:14679187). Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons (PubMed:10482766). {ECO:0000269|PubMed:10482766, ECO:0000269|PubMed:1378392, ECO:0000269|PubMed:14679187, ECO:0000305|PubMed:2023941}.
uniprot
proteins
mass_dalton
65857
uniprot
proteins
mutagenesis
MUTAGEN 220; /note="N->Q: Reduces extent of N-glycosylation. Abolishes N-glycosylation; when associated with Q-229."; /evidence="ECO:0000269|PubMed:24161696"; MUTAGEN 229; /note="N->Q: Reduces extent of N-glycosylation. Abolishes N-glycosylation; when associated with Q-220."; /evidence="ECO:0000269|PubMed:24161696
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; contains sialylated glycans. {ECO:0000269|PubMed:24161696}.
uniprot
proteins
protein_family
C (Shaw) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv3.1/KCNC1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10482766
uniprot
proteins
pubmed
1378392
uniprot
proteins
pubmed
14679187
uniprot
proteins
pubmed
2023941
uniprot
proteins
pubmed
20857303
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24161696
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10482766, ECO:0000269|PubMed:14679187, ECO:0000269|PubMed:24161696}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000269|PubMed:20857303}. Presynaptic cell membrane {ECO:0000269|PubMed:20857303}. Note=Localizes in parallel fiber membranes, distributed on the perisynaptic and extrasynaptic membranes away from the active zones. {ECO:0000269|PubMed:20857303}.
uniprot
proteins
transmembrane_region
TRANSMEM 191..209; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 248..267; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 277..295; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 309..331; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 345..366; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 415..436; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins