KPNA5
entrez
3841
canonical
uniprot
O15131
canonical
ensembl
ENSG00000196911
resolver
ensp
ENSP00000348704
resolver
ensp
ENSP00000357552
resolver
ensp
ENSP00000513404
resolver
ensp
ENSP00000513406
resolver
ensp
ENSP00000780908
resolver
ensp
ENSP00000791619
resolver
enst
ENST00000356348
resolver
enst
ENST00000368564
resolver
enst
ENST00000697697
resolver
enst
ENST00000697699
resolver
genesymbol
KPNA5
resolver
hgnc
HGNC:6398
resolver
uniprot
A0A8V8TL88
resolver
uniprot
A0A8V8TMV2
resolver
uniprot
B2RAI5
resolver
uniprot
Q86X23
resolver
uniprot_entry
A0A8V8TL88_HUMAN
resolver
uniprot_entry
A0A8V8TMV2_HUMAN
resolver
uniprot_entry
IMA6_HUMAN
resolver
uniprot_sec
B2RAI5
resolver
uniprot_sec
Q86X23
resolver
amino_acid_sequence
MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEAPMDGFQL
uniprot
proteins
function
FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
uniprot
proteins
mass_dalton
60666
uniprot
proteins
protein_family
Importin alpha family
uniprot
proteins
pubmed
12610148
uniprot
proteins
pubmed
12740372
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17928350
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
9395085
uniprot
proteins
sequence_length
539
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins