ILF3
entrez
3609
canonical
uniprot
Q12906
canonical
ensembl
ENSG00000129351
resolver
ensp
ENSP00000250241
resolver
ensp
ENSP00000384660
resolver
ensp
ENSP00000465219
resolver
ensp
ENSP00000468156
resolver
ensp
ENSP00000468181
resolver
ensp
ENSP00000569750
resolver
ensp
ENSP00000569751
resolver
ensp
ENSP00000569752
resolver
ensp
ENSP00000608472
resolver
ensp
ENSP00000608474
resolver
ensp
ENSP00000608477
resolver
ensp
ENSP00000608478
resolver
ensp
ENSP00000640451
resolver
ensp
ENSP00000681323
resolver
ensp
ENSP00000741001
resolver
ensp
ENSP00000741002
resolver
ensp
ENSP00000741008
resolver
ensp
ENSP00000741009
resolver
ensp
ENSP00000741011
resolver
genesymbol
ILF3
resolver
genesymbol_syn
DRBF
resolver
genesymbol_syn
MPHOSPH4
resolver
genesymbol_syn
NF90
resolver
hgnc
HGNC:6038
resolver
uniprot
A8K6F2
resolver
uniprot
G5E9M5
resolver
uniprot
O43409
resolver
uniprot
Q6P1X1
resolver
uniprot
Q86XY7
resolver
uniprot
Q99544
resolver
uniprot
Q99545
resolver
uniprot
Q9BZH4
resolver
uniprot
Q9BZH5
resolver
uniprot
Q9NQ95
resolver
uniprot
Q9NQ96
resolver
uniprot
Q9NQ97
resolver
uniprot
Q9NQ98
resolver
uniprot
Q9NQ99
resolver
uniprot
Q9NQA0
resolver
uniprot
Q9NQA1
resolver
uniprot
Q9NQA2
resolver
uniprot
Q9NRN2
resolver
uniprot
Q9NRN3
resolver
uniprot
Q9NRN4
resolver
uniprot
Q9UMZ9
resolver
uniprot
Q9UN00
resolver
uniprot
Q9UN84
resolver
uniprot
Q9UNA2
resolver
uniprot_entry
ILF3_HUMAN
resolver
uniprot_sec
A8K6F2
resolver
uniprot_sec
G5E9M5
resolver
uniprot_sec
O43409
resolver
uniprot_sec
Q6P1X1
resolver
uniprot_sec
Q86XY7
resolver
uniprot_sec
Q99544
resolver
uniprot_sec
Q99545
resolver
uniprot_sec
Q9BZH4
resolver
uniprot_sec
Q9BZH5
resolver
uniprot_sec
Q9NQ95
resolver
uniprot_sec
Q9NQ96
resolver
uniprot_sec
Q9NQ97
resolver
uniprot_sec
Q9NQ98
resolver
uniprot_sec
Q9NQ99
resolver
uniprot_sec
Q9NQA0
resolver
uniprot_sec
Q9NQA1
resolver
uniprot_sec
Q9NQA2
resolver
uniprot_sec
Q9NRN2
resolver
uniprot_sec
Q9NRN3
resolver
uniprot_sec
Q9NRN4
resolver
uniprot_sec
Q9UMZ9
resolver
uniprot_sec
Q9UN00
resolver
uniprot_sec
Q9UN84
resolver
uniprot_sec
Q9UNA2
resolver
amino_acid_sequence
MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQAESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKLVSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLALDANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRGFGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR
uniprot
proteins
function
FUNCTION: RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}.
uniprot
proteins
mass_dalton
95338
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-188 and Thr-315 by PKR in response to certain RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication. {ECO:0000269|PubMed:21123651}.; PTM: Methylated by protein arginine N-methyltransferase 1. {ECO:0000269|PubMed:10749851}.; PTM: Ubiquitinated at Lys-297 in a TRIM47-dependent manner; this 'Lys-48'-linked ubiquitination promotes ILF3 degradation. {ECO:0000269|PubMed:34110282}.
uniprot
proteins
pubmed
10400669
uniprot
proteins
pubmed
10574923
uniprot
proteins
pubmed
10607473
uniprot
proteins
pubmed
10749851
uniprot
proteins
pubmed
11161820
uniprot
proteins
pubmed
11167023
uniprot
proteins
pubmed
11438536
uniprot
proteins
pubmed
11739746
uniprot
proteins
pubmed
11777942
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
14570900
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14731398
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15254228
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17289661
uniprot
proteins
pubmed
17890166
uniprot
proteins
pubmed
17932509
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19029303
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21123651
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
26240280
uniprot
proteins
pubmed
26891316
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28625552
uniprot
proteins
pubmed
34110282
uniprot
proteins
pubmed
7519613
uniprot
proteins
pubmed
8885239
uniprot
proteins
pubmed
9442054
uniprot
proteins
sequence_length
894
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:26240280}. Cytoplasm {ECO:0000269|PubMed:28625552}. Nucleus {ECO:0000269|PubMed:10749851, ECO:0000269|PubMed:26240280, ECO:0000269|PubMed:28625552}. Note=Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269|PubMed:21123651}.
uniprot
proteins