Map2k4
entrez
26398
canonical
uniprot
P47809
canonical
ensembl
ENSMUSG00000033352
resolver
ensp
ENSMUSP00000041282
resolver
ensp
ENSMUSP00000301231
resolver
enst
ENSMUST00000046963
resolver
genesymbol
Map2k4
resolver
genesymbol_syn
JNKK1
resolver
genesymbol_syn
Jnkk1
resolver
genesymbol_syn
MEK4
resolver
genesymbol_syn
MKK4
resolver
genesymbol_syn
Mek4
resolver
genesymbol_syn
Mkk4
resolver
genesymbol_syn
PRKMK4
resolver
genesymbol_syn
Prkmk4
resolver
genesymbol_syn
Sek1
resolver
genesymbol_syn
Serk1
resolver
genesymbol_syn
Skk1
resolver
uniprot
Q543X6
resolver
uniprot
Q8K2U0
resolver
uniprot_entry
MP2K4_MOUSE
resolver
uniprot_entry
Q543X6_MOUSE
resolver
uniprot_entry
Q8K2U0_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated in response to a variety of cellular stresses, including UV and gamma-irradiation, heat shock, hyperosmolarity, T-cell receptor stimulation, peroxide and inflammatory cytokines. Also activated by developmental cues. MAP2K4/MKK4 is activated by the majority of MKKKs, such as MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K7/TAK1, MAP3K10/MLK2, MAP3K11/MLK3, MAP3K12/DLK and MAP3K13/LZK. {ECO:0000269|PubMed:9891090}.
uniprot
proteins
amino_acid_sequence
MAAPSPSGGGGSGGGGGTPGPIGPPASGHPAVSSMQGKRKALKLNFANPPVKSTARFTLNPNTTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERTVEVACYVCKILDQMPATPSSPMYVD
uniprot
proteins
ec_number
2.7.12.2
uniprot
proteins
function
FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269|PubMed:11390361, ECO:0000269|PubMed:12624093, ECO:0000269|PubMed:7997269, ECO:0000269|PubMed:9620683, ECO:0000269|PubMed:9891090}.
uniprot
proteins
mass_dalton
44114
uniprot
proteins
mutagenesis
MUTAGEN 129; /note="K->R: Loss of ATP-binding."; /evidence="ECO:0000269|PubMed:7997269
uniprot
proteins
post_translational_modification
PTM: Activated by phosphorylation on Ser-255 and Thr-259 by MAP kinase kinase kinases (MAP3Ks). {ECO:0000250}.
uniprot
proteins
protein_family
MAP kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
10095085
uniprot
proteins
pubmed
11390361
uniprot
proteins
pubmed
12391307
uniprot
proteins
pubmed
12401521
uniprot
proteins
pubmed
12624093
uniprot
proteins
pubmed
17496909
uniprot
proteins
pubmed
17875933
uniprot
proteins
pubmed
19265040
uniprot
proteins
pubmed
20801953
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21333379
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
7997269
uniprot
proteins
pubmed
9620683
uniprot
proteins
pubmed
9891090
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9891090}. Nucleus {ECO:0000269|PubMed:9891090}.
uniprot
proteins