Tra2b
entrez
20462
canonical
uniprot
P62996
canonical
ensembl
ENSMUSG00000022858
resolver
ensp
ENSMUSP00000023564
resolver
ensp
ENSMUSP00000124846
resolver
ensp
ENSMUSP00000236386
resolver
enst
ENSMUST00000023564
resolver
genesymbol
Tra2b
resolver
genesymbol_syn
Sfrs10
resolver
genesymbol_syn
Silg41
resolver
uniprot
F8WJG3
resolver
uniprot
O15449
resolver
uniprot
Q15815
resolver
uniprot
Q64283
resolver
uniprot_entry
F8WJG3_MOUSE
resolver
uniprot_entry
TRA2B_MOUSE
resolver
uniprot_sec
O15449
resolver
uniprot_sec
Q15815
resolver
uniprot_sec
Q64283
resolver
amino_acid_sequence
MSDSGEQNYGERESRSASRSGSAHGSGKSARHTPARSRSKEDSRRSRSKSRSRSESRSRSRRSSRRHYTRSRSRSRSHRRSRSRSYSRDYRRRHSHSHSPMSTRRRHVGNRANPDPNCCLGVFGLSLYTTERDLREVFSKYGPIADVSIVYDQQSRRSRGFAFVYFENVDDAKEAKERANGMELDGRRIRVDFSITKRPHTPTPGIYMGRPTYGSSRRRDYYDRGYDRGYDDRDYYSRSYRGGGGGGGGWRAAQDRDQIYRRRSPSPYYSRGGYRSRSRSRSYSPRRY
uniprot
proteins
function
FUNCTION: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing (PubMed:28785060). Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA (By similarity). {ECO:0000250|UniProtKB:P62995, ECO:0000269|PubMed:28785060}.
uniprot
proteins
mass_dalton
33666
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in the RS domains. {ECO:0000250|UniProtKB:P62995}.
uniprot
proteins
protein_family
Splicing factor SR family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
28785060
uniprot
proteins
pubmed
7868905
uniprot
proteins
pubmed
8674539
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28785060}.
uniprot
proteins