SIK2
entrez
23235
canonical
uniprot
Q9H0K1
canonical
ensembl
ENSG00000170145
resolver
ensp
ENSP00000305976
resolver
enst
ENST00000304987
resolver
genesymbol
SIK2
resolver
genesymbol_syn
KIAA0781
resolver
genesymbol_syn
QIK
resolver
genesymbol_syn
SNF1LK2
resolver
hgnc
HGNC:21680
resolver
uniprot
A8K5B8
resolver
uniprot
B0YJ94
resolver
uniprot
O94878
resolver
uniprot
Q17RV0
resolver
uniprot
Q6AZE2
resolver
uniprot
Q76N03
resolver
uniprot
Q8NCV7
resolver
uniprot
Q96CZ8
resolver
uniprot_entry
SIK2_HUMAN
resolver
uniprot_sec
A8K5B8
resolver
uniprot_sec
B0YJ94
resolver
uniprot_sec
O94878
resolver
uniprot_sec
Q17RV0
resolver
uniprot_sec
Q6AZE2
resolver
uniprot_sec
Q76N03
resolver
uniprot_sec
Q8NCV7
resolver
uniprot_sec
Q96CZ8
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-175. {ECO:0000269|PubMed:14976552}.
uniprot
proteins
amino_acid_sequence
MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8CFH6, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:21084751, ECO:0000269|PubMed:23322770, ECO:0000269|PubMed:26983400}.
uniprot
proteins
mass_dalton
103915
uniprot
proteins
mutagenesis
MUTAGEN 175; /note="T->A: Prevents phosphorylation and activation by STK11/LKB1 complex."; /evidence="ECO:0000269|PubMed:14976552"; MUTAGEN 175; /note="T->E: Constitutively active."; /evidence="ECO:0000269|PubMed:14976552
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (PubMed:14976552). Phosphorylated at Thr-484 in response to insulin in adipocytes (PubMed:30586628). {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:30586628}.; PTM: Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6. {ECO:0000269|PubMed:23322770}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SNF1 subfamily
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14976552
uniprot
proteins
pubmed
15454081
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21084751
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23322770
uniprot
proteins
pubmed
24129571
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26983400
uniprot
proteins
pubmed
30586628
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
926
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24129571}.
uniprot
proteins