FYB2
entrez
199920
canonical
uniprot
Q5VWT5
canonical
ensembl
ENSG00000187889
resolver
ensp
ENSP00000345972
resolver
ensp
ENSP00000537661
resolver
ensp
ENSP00000639741
resolver
ensp
ENSP00000664308
resolver
ensp
ENSP00000664315
resolver
genesymbol
FYB2
resolver
genesymbol_syn
ARAP
resolver
genesymbol_syn
C1orf168
resolver
hgnc
HGNC:27295
resolver
uniprot
Q63HM3
resolver
uniprot
Q6ZUY6
resolver
uniprot_entry
FYB2_HUMAN
resolver
uniprot_sec
Q63HM3
resolver
uniprot_sec
Q6ZUY6
resolver
amino_acid_sequence
MEGEGVRNFKELRAKFQNLDAPPLPGPIKFPAGVSPKGDIGGTQSTQILANGKPLSSNHKQRTPYCSSSESQPLQPQKIKLAQKSEIPKCSNSPGPLGKSTVCSATSSQKASLLLEVTQSNVEIITKEKVMVANSFRNKLWNWEKVSSQKSEMSSALLLANYGSKAIHLEGQKGMGLTPEEPRKKLETKGAQTLPSQKHVVAPKILHNVSEDPSFVISQHIRKSWENPPPERSPASSPCQPIYECELASQAPEKQPDVRHHHLPKTKPLPSIDSLGPPPPKPSRPPIVNLQAFQRQPAAVPKTQGEVTVEEGSLSPERLFNAEFEEPHNYEATISYLRHSGNSINLCTAKEIADPTYEVGIEELQKPGKNFPYPEPSAKHEDKKMKEKQPCELKPKNTEKEPYSNHVFKVDACEGTPEKIQMTNVHTGRRNMLAGKQEAMIDIIQTNPCPEGPKLARHSQGHCGHLEVLESTKETPDLGVSKTSSISEEIYDDVEYSRKEVPKLNYSSSLASSSEENRELYEDVYKTKNNYPKIDLDGKEALKRLQQFFKKEKDRFKIKKTKSKENLSAFSILLPDLELKSQEVIIYDDVDLSEKESKDEDKLKMWKPKFLTPKEKKEKNGAEESESFSPRNFFKTKKQNLEKNRMKREEKLFRERFKYDKEIIVINTAVACSNNSRNGIFDLPISPGEELEVIDTTEQNLVICRNSKGKYGYVLIEHLDFKHQSWSP
uniprot
proteins
function
FUNCTION: Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation (PubMed:27335501). {ECO:0000269|PubMed:27335501}.
uniprot
proteins
mass_dalton
82070
uniprot
proteins
mutagenesis
MUTAGEN 491; /note="Y->F: Decrease in phosphorylation and interaction with LCP2. Significant decrease in phosphorylation and loss of interaction with LCP2; when associated with F-587."; /evidence="ECO:0000269|PubMed:27335501"; MUTAGEN 587; /note="Y->F: Decrease in phosphorylation and interaction with LCP2. Significant decrease in phosphorylation and loss of interaction with LCP2; when associated with F-491."; /evidence="ECO:0000269|PubMed:27335501
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is required for its function in T-cell activation. {ECO:0000269|PubMed:27335501}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
27335501
uniprot
proteins
sequence_length
728
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane raft {ECO:0000269|PubMed:27335501}. Note=Recruited to membrane rafts and immunological synapse after TCR stimulation. {ECO:0000269|PubMed:27335501}.
uniprot
proteins