Ahr
entrez
11622
canonical
uniprot
P30561
canonical
ensembl
ENSMUSG00000019256
resolver
ensp
ENSMUSP00000112137
resolver
enst
ENSMUST00000116436
resolver
genesymbol
Ahr
resolver
uniprot
F6TX41
resolver
uniprot
Q3U5D9
resolver
uniprot
Q8QZX6
resolver
uniprot
Q8R4S3
resolver
uniprot
Q99P79
resolver
uniprot
Q9QVY1
resolver
uniprot_entry
AHR_MOUSE
resolver
uniprot_entry
F6TX41_MOUSE
resolver
uniprot_entry
Q3U5D9_MOUSE
resolver
uniprot_sec
Q8QZX6
resolver
uniprot_sec
Q8R4S3
resolver
uniprot_sec
Q99P79
resolver
uniprot_sec
Q9QVY1
resolver
amino_acid_sequence
MSSGANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSTPADRNGGQDQCRAQIRDWQDLQEGEFLLQALNGFVLVVTADALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPDSAQGVDEAHGPPQAAVYYTPDQLPPENASFMERCFRCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGALLPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGQLILGYTEVELCTRGSGYQFIHAADMLHCAESHIRMIKTGESGMTVFRLFAKHSRWRWVQSNARLIYRNGRPDYIIATQRPLTDEEGREHLQKRSTSLPFMFATGEAVLYEISSPFSPIMDPLPIRTKSNTSRKDWAPQSTPSKDSFHPSSLMSALIQQDESIYLCPPSSPAPLDSHFLMGSVSKCGSWQDSFAAAGSEAALKHEQIGHAQDVNLALSGGPSELFPDNKNNDLYNIMRNLGIDFEDIRSMQNEEFFRTDSTAAGEVDFKDIDITDEILTYVQDSLNNSTLMNSACQQQPVTQHLSCMLQERLQLEQQQQLQQPPPQALEPQQQLCQMVCPQQDLGPKHTQINGTFASWNPTPPVSFNCPQQELKHYQLFSSLQGTAQEFPYKPEVDSVPYTQNFAPCNQPLLPEHSKSVQLDFPGRDFEPSLHPTTSNLDFVSCLQVPENQSHGINSQSTMVSPQAYYAGAMSMYQCQPGPQRTPVDQTQYSSEIPGSQAFLSKVQSRGIFNETYSSDLSSIGHAAQTTGHLHHLAEARPLPDITPGGFL
uniprot
proteins
function
FUNCTION: Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:10639156, PubMed:10973493, PubMed:1314586, PubMed:33436590, PubMed:7961644, PubMed:7969080, PubMed:8806883, PubMed:9427285). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (By similarity). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:20106950, PubMed:28396409). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:10639156, PubMed:10973493, PubMed:1314586, PubMed:7961644, PubMed:7969080, PubMed:8806883, PubMed:9427285). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (By similarity). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (By similarity). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (By similarity). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (By similarity). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (By similarity). Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:20106950).The heterodimer ARNT:AHR binds to the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409). {ECO:0000250|UniProtKB:P35869, ECO:0000269|PubMed:10639156, ECO:0000269|PubMed:10973493, ECO:0000269|PubMed:1314586, ECO:0000269|PubMed:20106950, ECO:0000269|PubMed:28396409, ECO:0000269|PubMed:33436590, ECO:0000269|PubMed:7961644, ECO:0000269|PubMed:7969080, ECO:0000269|PubMed:8806883, ECO:0000269|PubMed:9427285}.
uniprot
proteins
mass_dalton
95017
uniprot
proteins
mutagenesis
MUTAGEN 39; /note="R->D: Drastically reduces the binding affinity of AHR?ARNT to dioxin response element (DRE). Impairs ligand-induced nuclear translocation of AHR."; /evidence="ECO:0000269|PubMed:28396409"; MUTAGEN 42; /note="L->E: Significantly reduces binding affinities of the AHR?ARNT heterodimer to DRE."; /evidence="ECO:0000269|PubMed:28396409"; MUTAGEN 43; /note="N->A: Reduces the binding affinity of AHR?ARNT to the DRE by more than 10-fold."; /evidence="ECO:0000269|PubMed:28396409"; MUTAGEN 49; /note="L->E: Reduces the AHR induction transcription activity by 50%. Increases ligand-induced nuclear translocation of AHR."; /evidence="ECO:0000269|PubMed:28396409"; MUTAGEN 65; /note="K->E: Reduces the binding affinity of AHR?ARNT to the DRE by more than 10-fold."; /evidence="ECO:0000269|PubMed:28396409"; MUTAGEN 70; /note="R->D: Drastically reduces the AHR transcription activity induction. Increases constitutive AHR nuclear translocation in the absence of ligands. Reduces binding affinity for the DRE by more than 30-fold in vitro."; /evidence="ECO:0000269|PubMed:28396409"; MUTAGEN 112; /note="E->A: Reduces transcription activity. Decreases interaction with ARNT."; /evidence="ECO:0000269|PubMed:24001774"; MUTAGEN 115; /note="F->A: Highly disrupts the dimerization ability of AHR."; /evidence="ECO:0000269|PubMed:24001774"; MUTAGEN 115; /note="F->D: Highly disrupts the dimerization ability of AHR. Reduces the AHR transcription factor activity induction by 50%."; /evidence="ECO:0000269|PubMed:24001774, ECO:0000269|PubMed:28396409"; MUTAGEN 116; /note="L->E: Highly disrupts the dimerization ability of AHR. Reduces transcription activity. Decreases interaction with ARNT."; /evidence="ECO:0000269|PubMed:24001774"; MUTAGEN 119; /note="A->D: Highly disrupts the dimerization ability of AHR. Reduces transcription activity. Impairs interaction with ARNT."; /evidence="ECO:0000269|PubMed:24001774"; MUTAGEN 120; /note="L->D: Significantly reduces binding affinities of the AHR?ARNT heterodimer to DRE."; /evidence="ECO:0000269|PubMed:28396409"; MUTAGEN 120; /note="L->E: Highly disrupts the dimerization ability of AHR. Reduces transcription activity. Impairs interaction with ARNT."; /evidence="ECO:0000269|PubMed:24001774"; MUTAGEN 124; /note="V->D: Highly disrupts the dimerization ability of AHR. Reduces transcription activity. Impairs interaction with ARNT."; /evidence="ECO:0000269|PubMed:24001774"; MUTAGEN 134; /note="F->D: Reduces the AHR induction activity by ~50%. Translocates to the nucleus at a high level."; /evidence="ECO:0000269|PubMed:28396409"; MUTAGEN 152; /note="I->D: Completely abolished the AHR induction activity, the ligand-induced nuclear translocation of AHR, and drastically reduced DRE-binding in vitro."; /evidence="ECO:0000269|PubMed:28396409"; MUTAGEN 238; /note="K->D: Significantly reduces binding affinities of the AHR:ARNT heterodimer to DRE."; /evidence="ECO:0000269|PubMed:28396409"; MUTAGEN 240; /note="L->D: Significantly reduces binding affinities of the AHR:ARNT heterodimer to DRE."; /evidence="ECO:0000269|PubMed:28396409"; MUTAGEN 260; /note="F->D: Reduces transcription activity. Impairs interaction with ARNT."; /evidence="ECO:0000269|PubMed:24001774"; MUTAGEN 262; /note="I->D: Reduces transcription activity. Decreases interaction with ARNT."; /evidence="ECO:0000269|PubMed:24001774
uniprot
proteins
post_translational_modification
PTM: Mono-ADP-ribosylated, leading to inhibit transcription activator activity of AHR. {ECO:0000250|UniProtKB:P35869}.
uniprot
proteins
pubmed
10639156
uniprot
proteins
pubmed
10973493
uniprot
proteins
pubmed
11875369
uniprot
proteins
pubmed
11956195
uniprot
proteins
pubmed
12213388
uniprot
proteins
pubmed
12215427
uniprot
proteins
pubmed
1314586
uniprot
proteins
pubmed
1325649
uniprot
proteins
pubmed
15581363
uniprot
proteins
pubmed
1846217
uniprot
proteins
pubmed
20106950
uniprot
proteins
pubmed
24001774
uniprot
proteins
pubmed
28396409
uniprot
proteins
pubmed
29726989
uniprot
proteins
pubmed
33436590
uniprot
proteins
pubmed
7961644
uniprot
proteins
pubmed
7969080
uniprot
proteins
pubmed
8148872
uniprot
proteins
pubmed
8408082
uniprot
proteins
pubmed
8806768
uniprot
proteins
pubmed
8806883
uniprot
proteins
pubmed
9427285
uniprot
proteins
sequence_length
848
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12215427, ECO:0000269|PubMed:28396409}. Nucleus {ECO:0000269|PubMed:12215427, ECO:0000269|PubMed:20106950, ECO:0000269|PubMed:28396409}. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. {ECO:0000269|PubMed:20106950, ECO:0000269|PubMed:28396409}.
uniprot
proteins