Mapre1
entrez
114764
canonical
uniprot
Q66HR2
canonical
ensembl
ENSRNOG00000011798
resolver
ensembl
ENSRNOG00055025419
resolver
ensembl
ENSRNOG00060021603
resolver
ensembl
ENSRNOG00065024797
resolver
ensp
ENSRNOP00000016220
resolver
ensp
ENSRNOP00055035823
resolver
ensp
ENSRNOP00060030892
resolver
ensp
ENSRNOP00065034846
resolver
enst
ENSRNOT00000016220
resolver
enst
ENSRNOT00055043838
resolver
enst
ENSRNOT00060037487
resolver
enst
ENSRNOT00065042584
resolver
genesymbol
Mapre1
resolver
uniprot_entry
MARE1_RAT
resolver
amino_acid_sequence
MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKEYDPVAARQGQETAVAPSLVAPALSKPKKPLGSGSAAPQRPIATQRTTAAPKAGPGMVRKNPGMGNGDDEAAELMQQVKVLKLTVEDLEKERDFYFGKLRNIELICQENEGENDPVLQRIVDILYATDEGFVIPDEGGPQEEQEEY
uniprot
proteins
function
FUNCTION: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains. Promotes cytoplasmic microtubule nucleation and elongation. Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation. Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (By similarity). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (By similarity). Promotes microtubule-mediated GJA1/CX43 trafficking to cell membranes via its interaction with DSP, thereby facilitating gap junction intracellular communication (PubMed:25225338). May play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:Q15691, ECO:0000250|UniProtKB:Q61166, ECO:0000269|PubMed:25225338}.
uniprot
proteins
mass_dalton
30004
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-220 by KAT2B/PCAF promotes dynamic kinetochore-microtubule interactions in early mitosis. {ECO:0000250|UniProtKB:Q15691}.; PTM: Crotonylated by KAT5 during mitosis, promoting astral microtubule plasticity and dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation, thereby ensuring accurate spindle positioning in mitosis. Decrotonylated by HDAC3. {ECO:0000250|UniProtKB:Q15691}.
uniprot
proteins
protein_family
MAPRE family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19553473
uniprot
proteins
pubmed
21357749
uniprot
proteins
pubmed
25225338
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q15691}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q15691}. Golgi apparatus {ECO:0000250|UniProtKB:Q15691}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q15691}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q15691}. Cell membrane {ECO:0000250|UniProtKB:Q15691}. Note=Associated with the microtubule growing distal tips. In addition to localizing to microtubule plus-ends, also exhibits some localization along the length of the microtubules. Recruitment to the Golgi apparatus requires the presence of PDE4DIP isoform 13/MMG8/SMYLE. {ECO:0000250|UniProtKB:Q15691}.
uniprot
proteins