A0A140LI67
uniprot
A0A140LI67
canonical
amino_acid_sequence
MRPLAKDTGMSVASVTLASALQVRGEALSEEEIWSLLSLAAERLLEDLRNDSSDYVVCPWSLLLSAAGGLSFQDHVSHIEAAPFKAPELLQGSNEEGQPDASQMHVYSLGMTLYWSAGFRVPPNQPLQLQEPVHSLLLAMCEDQPRRRQPLQAVLEACRIHQEEVAVYPAPASLHISRLVGLVLGTISEVERRVVEENACEQRNRSCSLRSRLHQADGESPGAPASDALQPRRVSERSAETQSSLERCTAHSRNSFVNSTFAGAGPCDCEESPWYGSEPMLLAEAESSQPATSSPRNFLQRKGKFSRPEFILLAGEAPVTLHLPGSIVTKKGKSYLALRDLCVVLLNGRCLEVKCDMESTAGAVFNAVMSFANLEETTYFGLAYVEGEEFFFLDKDTRLCKVAPEGWREQHPKGSVDTFTLFLRIRFFVGHYRLLRHSLTRHQFYLQLRKDILEERLYCNDETLLQLGVLALQAEFGSYPKEQVEGKAYFRIQDYIPARLIERMTAIRVQVEVSEMHRLSSAPWGEDAELEFLEIVQQLPEYGVLVHRVSPEKKRPEGKMALGVCTKGIIVYEVRGSRRIATSQFPWRETGMISTHRKKLTITSSTTGKKYTFVTNSSKTCKYLLGLCSSQHWFNAQTGSKHPSHRFTGQDKFAQIASLSSAHQTQANPITWIQKLSCSENELCVPRLQDATGGQLGTSMENKQGFKEPGKERIGSSPYTGGEQLHSIGLNQKPAQTVFGTAGHSMCAGSNCLGRRTQICCFDSVSGSQNSKRKGLFGEPNQDIVCVMLKRDPVHGFGFVINEGEDAEQTRSGIFISSLIPGGPAERAKKIKPGGKILALNHISLEGFTFSMAVRMIQNSPDDMELIISQPKGVCGTIHSEEKNSTASSGMFCTDILSNRCQGRQSPHIHDQDRSVRGTEMAQGAGSCPPSPLQTNTGEIYFVELVKEDGTLGFSVTGGINTSVPHGGIYVKSIIPGGPAAKEGQILQGDRLLQVDGVSLCGLTHKQAVQCLKGPGQVARLVLERRGPRAAPQCPSADDRMGDVHMAVSLVTARPGRPASSVSVTDGPKFEVKLKKNSRGLGFSFVQMERGNCIHTKSDLVRIKRLFPGQPAEEHGAIAAGDIILAVNGKPIEGLAFQEVLHLLRGAPEEVTLLLCRPPPGILPEMEPGWQTPELSGDQRLTMATCAGSEQSPSLDQEDNWRDSTSLDAGEGLSPGPESSYKDVRQVKGDREKERPWAKSWMHPMESHPHVCKLHPEPETPALATSLEKDMRQNCYSVCDIRRLGSLELDRDGADGATCFLPESSSLTVDYEEYLTLTSASAGQLPCEECLEADSETIPLPQFCSLGALLKSSLPEESQGSESDWEDLDEPVDRDEVLRWTRSARQPLAAEP
uniprot
proteins
function
FUNCTION: Functions as a scaffold protein and likely plays a role in N-methyl-D-aspartic acid receptor (NMDAR)-mediated synaptic excitatory transmission (PubMed:31196628). May be involved in synapse formation in cone photoreceptor cells (PubMed:29590622). May play a role in the regulation of tight junction formation (By similarity). Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (By similarity). May pNF-kappa-Blay a role in the regulation of NOD2-mediated NF-kappa-B activation in immune response (By similarity). {ECO:0000250|UniProtKB:Q68DX3, ECO:0000269|PubMed:29590622, ECO:0000269|PubMed:31196628}.
uniprot
proteins
mass_dalton
152851
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
29590622
uniprot
proteins
pubmed
31196628
uniprot
proteins
sequence_length
1392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q68DX3}. Postsynaptic density {ECO:0000269|PubMed:31196628}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q68DX3}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q68DX3}. Note=Colocalizes with CTNNB1, CDH1 and PKP4 at the basolateral membrane. Colocalizes with TJP1 at tight junctions. Its recruitment to cell-cell contacts requires CDH1. Colocalizes with NOD2 to the basolacteral membrane in intestinal epithelial cells. {ECO:0000250|UniProtKB:Q68DX3}.
uniprot
proteins