Nr1i2
entrez
18171
canonical
uniprot
O54915
canonical
ensembl
ENSMUSG00000022809
resolver
ensp
ENSMUSP00000023504
resolver
ensp
ENSMUSP00000348663
resolver
genesymbol
Nr1i2
resolver
genesymbol_syn
Pxr
resolver
uniprot
Q0P525
resolver
uniprot_entry
NR1I2_MOUSE
resolver
uniprot_entry
Q0P525_MOUSE
resolver
amino_acid_sequence
MRPEESWSRVGLVQCEEADSALEEPINVEEEDGGLQICRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFRKGTCEITRKTRRQCQACRLRKCLESGMKKEMIMSDAAVEQRRALIKRKKREKIEAPPPGGQGLTEEQQALIQELMDAQMQTFDTTFSHFKDFRLPAVFHSGCELPEFLQASLLEDPATWSQIMKDRVPMKISLQLRGEDGSIWNYQPPSKSDGKEIIPLLPHLADVSTYMFKGVINFAKVISYFRDLPIEDQISLLKGATFEMCILRFNTMFDTETGTWECGRLAYCFEDPNGGFQKLLLDPLMKFHCMLKKLQLHKEEYVLMQAISLFSPDRPGVVQRSVVDQLQERFALTLKAYIECSRPYPAHRFLFLKIMAVLTELRSINAQQTQQLLRIQDSHPFATPLMQELFSSTDG
uniprot
proteins
function
FUNCTION: Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. Activated by a broad range of endogenous steroids (e.g. pregnenolone, progesterone) and xenobiotics, including the antibiotic rifampicin and certain plant-derived metabolites. Upon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation. Target genes include cytochrome P450 enzymes such as CYP3A4 and ATP-binding cassette transporters including ABCB1/MDR1. {ECO:0000250|UniProtKB:O75469}.
uniprot
proteins
mass_dalton
49567
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKC at Thr-405. {ECO:0000250|UniProtKB:O75469}.; PTM: Ubiquitinated by RBCK1, leading to proteasomal degradation. Ubiquitinated in a FBXO44-dependent manner also leads to proteasomal degradation. {ECO:0000250|UniProtKB:O75469}.
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
12569201
uniprot
proteins
pubmed
12606758
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19297428
uniprot
proteins
pubmed
28751364
uniprot
proteins
pubmed
9489701
uniprot
proteins
sequence_length
431
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
uniprot
proteins