Izumo1
entrez
499152
canonical
uniprot
Q6AY06
canonical
ensembl
ENSRNOG00000089371
resolver
ensembl
ENSRNOG00055006637
resolver
ensembl
ENSRNOG00060010419
resolver
ensembl
ENSRNOG00065031178
resolver
ensp
ENSRNOP00000107803
resolver
ensp
ENSRNOP00055008389
resolver
ensp
ENSRNOP00060013699
resolver
ensp
ENSRNOP00065044201
resolver
enst
ENSRNOT00000160746
resolver
enst
ENSRNOT00055010805
resolver
enst
ENSRNOT00060017622
resolver
enst
ENSRNOT00065053759
resolver
genesymbol
Izumo1
resolver
uniprot_entry
IZUM1_RAT
resolver
amino_acid_sequence
MGLHFTLLLAALANCLCPARLCIICDPFVVAAIKTLEQNYLPTHLAPEHHEDVMKRVEQEVRNFADLPLNQNTFLGVVDEDTLEQASWSFLKDLKRITDSDVKGELFVKELFWMLRLQKDIFATLVARFQKEVYCPNQCGTMSQTLIWCNKCEKQMHFCRKSMDCGERQIEVHRLEDMVLDCQLSWHHASEGLTDYSFYRVWGNSSETLMSKGKEPYLTKTMVGPEDAGNYRCELDTVNAGPATIIYYHVTVLPPRSVEEKPPPNIVTQEEEETPVQVIVPTLEPEPEPEPIPTVTHRPEKKLKSRLLILLILGFVVLVASVIASVLHFRKTRVKSKNSNVENKTSAAEFKSEAESPQKMGSRKLSQAEFHTDSSDKVEEADN
uniprot
proteins
function
FUNCTION: Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen' (By similarity). Plays a critical role in sperm-oolemma binding prior to plasma membrane fusion (PubMed:35096839). Can mediate cell-cell fusion in cultured mammalian cells independently of its binding to IZUMO1R/JUNO (By similarity). {ECO:0000250|UniProtKB:Q9D9J7, ECO:0000269|PubMed:35096839}.
uniprot
proteins
mass_dalton
43579
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Glycosylation is not essential for fusion and for proper protein trafficking in sperm. {ECO:0000250|UniProtKB:Q9D9J7}.; PTM: Phosphorylated. The cytoplasmic C-terminus is phosphorylated and undergoes phosphorylation changes during epididymal transit. {ECO:0000250|UniProtKB:Q9D9J7}.
uniprot
proteins
protein_family
Izumo family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15759005
uniprot
proteins
pubmed
19658160
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
35096839
uniprot
proteins
pubmed
37951137
uniprot
proteins
sequence_length
383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37951137}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q9D9J7}; Single-pass type I membrane protein {ECO:0000255}. Note=Localizes initially to the acrosome membrane of the sperm head (both outer and inner acrosomal membranes). During the acrosome reaction, translocates to the plasma membrane. {ECO:0000250|UniProtKB:Q9D9J7}.
uniprot
proteins
transmembrane_region
TRANSMEM 307..327; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins