Plekhm2
entrez
69582
canonical
uniprot
Q80TQ5
canonical
ensembl
ENSMUSG00000028917
resolver
ensp
ENSMUSP00000030751
resolver
ensp
ENSMUSP00000081221
resolver
ensp
ENSMUSP00000266013
resolver
enst
ENSMUST00000030751
resolver
enst
ENSMUST00000084203
resolver
genesymbol
Plekhm2
resolver
genesymbol_syn
Kiaa0842
resolver
uniprot
A2ADE0
resolver
uniprot
A2ADE1
resolver
uniprot
Q3U0Q7
resolver
uniprot
Q6PD22
resolver
uniprot
Z4YJW6
resolver
uniprot_entry
A2ADE0_MOUSE
resolver
uniprot_entry
PKHM2_MOUSE
resolver
uniprot_entry
Z4YJW6_MOUSE
resolver
uniprot_sec
A2ADE1
resolver
uniprot_sec
Q3U0Q7
resolver
uniprot_sec
Q6PD22
resolver
amino_acid_sequence
MEPREVKDRILENISLSVKKLQSYFAACEDETPAIRNHDKVLQRLCEHLDHALLYGLQDLSSGYWVLVVHFTRREAIRQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLQKYYVRNALVCSHDHLTLFLTLVSGLEFIRFDLDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDGDLTDTISGPRSTASDLTSSKTSTKSPTQRHNPFNEEQAETASSDTTPVHTTSQEKEEAQAPDQPDACTELEVIRVTKKKKIGKKKKTKLDEDASPLHPTSSQQKCGQQGEGDGLVGTPGLARDPSDTVLASPQEQGEGLSSTAGSSELSELSQMGLLIPEMKDTSMECLGQPLSKVIDKLHGQLDPSTWCSHADPPEQSFRAGSPGEAPEKPPFCDFSEGLPAPMDFYRFTVESPSTVAPGGGHHDPPGPSQPLHVPGSPAAALQEEEEGGRGEGQTSQPVEDRQGEEIQEPEPQEPDSQLPLVSQEPLVSQEPVPEPVSQPEPGTHEALCKLKRDQPSPCLSSAEDSGVEEGQGSPSEMTHPSEFRVDNNHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAELFLASLKSAMIKGCREPPYPSILTDATMEKLALAKFVAQESKCEASAVTVHFYGLVHWEDPMEEALGPVPCQCSPAEGTITKEGMLHYKASTSYLGKEHWKACFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRSNTTDRPHAFQVILADRPCLELSADSEAEMADWMQHLCQAVSKGVIPQGIAPSPCIPCCLVITEDRLFTCHEDCQTSFFRSLGTARLADITAISTELGKEYCVLEFSQDSPQLLQPWVIYLSCTSELDRFLTALSSGWKAIYQVDLPHKAIHEASIKQKFEDALSLIHSAWQRSDSLCRGRASRDPWC
uniprot
proteins
function
FUNCTION: Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility. Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation. {ECO:0000250|UniProtKB:Q8IWE5}.
uniprot
proteins
mass_dalton
112734
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1018
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8IWE5}. Lysosome membrane {ECO:0000250|UniProtKB:Q8IWE5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8IWE5}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8IWE5}.
uniprot
proteins