KLRF2
entrez
100431172
canonical
uniprot
D3W0D1
canonical
ensembl
ENSG00000256797
resolver
ensp
ENSP00000438244
resolver
enst
ENST00000535540
resolver
genesymbol
KLRF2
resolver
hgnc
HGNC:37646
resolver
uniprot_entry
KLRF2_HUMAN
resolver
amino_acid_sequence
MENEDGYMTLSFKNRCKSKQKSKDFSLYPQYYCLLLIFGCIVILIFIMTGIDLKFWHKKMDFSQNVNVSSLSGHNYLCPNDWLLNEGKCYWFSTSFKTWKESQRDCTQLQAHLLVIQNLDELEFIQNSLKPGHFGWIGLYVTFQGNLWMWIDEHFLVPELFSVIGPTDDRSCAVITGNWVYSEDCSSTFKGICQRDAILTHNGTSGV
uniprot
proteins
function
FUNCTION: C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A (PubMed:20194751, PubMed:25510854). Triggers degranulation in a SYK-dependent manner and stimulates SYK phosphotyrosinylation without recruiting SYK directly (PubMed:28082678). {ECO:0000269|PubMed:20194751, ECO:0000269|PubMed:28082678}.
uniprot
proteins
mass_dalton
24008
uniprot
proteins
mutagenesis
MUTAGEN 7; /note="Y->F: Loss of function."; /evidence="ECO:0000269|PubMed:20194751, ECO:0000269|PubMed:28082678
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:20194751}.
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
20194751
uniprot
proteins
pubmed
23803857
uniprot
proteins
pubmed
25510854
uniprot
proteins
pubmed
28082678
uniprot
proteins
sequence_length
207
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20194751}; Single-pass type II membrane protein {ECO:0000269|PubMed:20194751}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins