Ca2
entrez
54231
canonical
uniprot
P27139
canonical
ensembl
ENSRNOG00000009629
resolver
ensembl
ENSRNOG00055025852
resolver
ensembl
ENSRNOG00060024092
resolver
ensembl
ENSRNOG00065013057
resolver
ensp
ENSRNOP00000013354
resolver
ensp
ENSRNOP00055036519
resolver
ensp
ENSRNOP00060034631
resolver
ensp
ENSRNOP00065016571
resolver
enst
ENSRNOT00000013354
resolver
enst
ENSRNOT00055044614
resolver
enst
ENSRNOT00060041771
resolver
enst
ENSRNOT00065021413
resolver
genesymbol
Ca2
resolver
uniprot_entry
CAH2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by acetazolamide. {ECO:0000250|UniProtKB:P00918}.
uniprot
proteins
amino_acid_sequence
MSHHWGYSKSNGPENWHKEFPIANGDRQSPVDIDTGTAQHDPSLQPLLICYDKVASKSIVNNGHSFNVEFDDSQDFAVLKEGPLSGSYRLIQFHFHWGSSDGQGSEHTVNKKKYAAELHLVHWNTKYGDFGKAVQHPDGLAVLGIFLKIGPASQGLQKITEALHSIKTKGKRAAFANFDPCSLLPGNLDYWTYPGSLTTPPLLECVTWIVLKEPITVSSEQMSHFRKLNFNSEGEAEELMVDNWRPAQPLKNRKIKASFK
uniprot
proteins
ec_number
4.2.1.1
uniprot
proteins
ec_number
4.2.1.69
uniprot
proteins
function
FUNCTION: Catalyzes the reversible hydration of carbon dioxide (By similarity). Can also hydrate cyanamide to urea (By similarity). Involved in the regulation of fluid secretion into the anterior chamber of the eye (By similarity). Essential for bone resorption and osteoclast differentiation (PubMed:9665810). Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption (By similarity). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (By similarity). {ECO:0000250|UniProtKB:P00918, ECO:0000269|PubMed:9665810}.
uniprot
proteins
mass_dalton
29114
uniprot
proteins
protein_family
Alpha-carbonic anhydrase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1765271
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9074494
uniprot
proteins
pubmed
9665810
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P00918}. Cell membrane {ECO:0000250|UniProtKB:P00918}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells (By similarity). {ECO:0000250|UniProtKB:P00918}.
uniprot
proteins