ADSS
entrez
159
canonical
uniprot
P30520
canonical
ensembl
ENSG00000035687
resolver
ensp
ENSP00000355493
resolver
ensp
ENSP00000733794
resolver
enst
ENST00000366535
resolver
genesymbol
ADSS
resolver
genesymbol
ADSS2
resolver
genesymbol_syn
ADSS
resolver
genesymbol_syn
ADSS2
resolver
hgnc
HGNC:292
resolver
uniprot
A0A024R5Q7
resolver
uniprot
A0A384MEI4
resolver
uniprot
B1AQM5
resolver
uniprot
Q96EG7
resolver
uniprot_entry
A0A024R5Q7_HUMAN
resolver
uniprot_entry
PURA2_HUMAN
resolver
uniprot_sec
A0A384MEI4
resolver
uniprot_sec
B1AQM5
resolver
uniprot_sec
Q96EG7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited competitively by AMP and IMP and non-competitively by fructose 1,6-bisphosphate. {ECO:0000250|UniProtKB:P46664}.
uniprot
proteins
amino_acid_sequence
MAFAETYPAASSLPNGDCGRPRARPGGNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVNAQNYVRFIEDELQIPVKWIGVGKSRESMIQLF
uniprot
proteins
ec_number
6.3.4.4
uniprot
proteins
function
FUNCTION: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. {ECO:0000250|UniProtKB:P46664}.
uniprot
proteins
mass_dalton
50097
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. {ECO:0000255|HAMAP-Rule:MF_03127}.
uniprot
proteins
protein_family
Adenylosuccinate synthetase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1592113
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03127}. Mitochondrion {ECO:0000250|UniProtKB:A4Z6H1}. Note=Partially associated with particulate fractions.
uniprot
proteins