Cyp2r1
entrez
244209
canonical
uniprot
Q6VVW9
canonical
ensembl
ENSMUSG00000030670
resolver
ensp
ENSMUSP00000032908
resolver
ensp
ENSMUSP00000283937
resolver
ensp
ENSMUSP00000283938
resolver
enst
ENSMUST00000032908
resolver
genesymbol
Cyp2r1
resolver
uniprot
Q32MW1
resolver
uniprot_entry
CP2R1_MOUSE
resolver
uniprot_entry
Q32MW1_MOUSE
resolver
amino_acid_sequence
MLELPGARACAGALAGALLLLLFVLVVRQLLRQRRPAGFPPGPPRLPFVGNICSLALSADLPHVYMRKQSRVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWIDHRRLAVNSFHYFGSGQKSFESKILEETWSLIDAIETYKGGPFDLKQLITNAVSNITNLILFGERFTYEDTDFQHMIELFSENVELAASAPVFLYNAFPWIGILPFGKHQRLFRNADVVYDFLSRLIEKAAVNRKPHLPHHFVDAYLDEMDQGQNDPLSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVHKEIDLIVGHNRRPSWEYKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWKDPDMFYPERFLDSNGYFTKKEALIPFSLGRRHCLGEQLARMEMFLFFTSLLQQFHLHFPHELVPNLKPRLGMTLQPQPYLICAERR
uniprot
proteins
ec_number
1.14.14.24
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in activation of vitamin D precursors (PubMed:12867411, PubMed:24019477). Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D(2) and D(3) (calciol). Can metabolize vitamin D analogs/prodrugs 1alpha-hydroxyvitamin D(2) (doxercalciferol) and 1alpha-hydroxyvitamin D(3) (alfacalcidol) forming 25-hydroxy derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity) (PubMed:12867411, PubMed:24019477). {ECO:0000250|UniProtKB:Q6VVX0, ECO:0000269|PubMed:12867411, ECO:0000269|PubMed:24019477}.
uniprot
proteins
mass_dalton
57313
uniprot
proteins
pathway_participation
PATHWAY: Hormone biosynthesis; vitamin D biosynthesis. {ECO:0000250|UniProtKB:Q6VVX0}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
12867411
uniprot
proteins
pubmed
24019477
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6VVX0}; Peripheral membrane protein. Microsome membrane {ECO:0000250|UniProtKB:Q6VVX0}; Peripheral membrane protein.
uniprot
proteins