DDX5
entrez
1655
canonical
uniprot
P17844
canonical
ensembl
ENSG00000108654
resolver
ensp
ENSP00000225792
resolver
ensp
ENSP00000403085
resolver
ensp
ENSP00000462885
resolver
ensp
ENSP00000463168
resolver
ensp
ENSP00000544441
resolver
enst
ENST00000578804
resolver
genesymbol
DDX5
resolver
genesymbol_syn
G17P1
resolver
genesymbol_syn
HELR
resolver
genesymbol_syn
HLR1
resolver
hgnc
HGNC:2746
resolver
uniprot
B4DLW8
resolver
uniprot
B5BU21
resolver
uniprot
D3DU32
resolver
uniprot
E7ETL9
resolver
uniprot
J3KTA4
resolver
uniprot
O75681
resolver
uniprot
Q53Y61
resolver
uniprot_entry
DDX5_HUMAN
resolver
uniprot_entry
J3KTA4_HUMAN
resolver
uniprot_sec
B4DLW8
resolver
uniprot_sec
B5BU21
resolver
uniprot_sec
D3DU32
resolver
uniprot_sec
E7ETL9
resolver
uniprot_sec
O75681
resolver
uniprot_sec
Q53Y61
resolver
amino_acid_sequence
MSGYSSDRDRGRDRGFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDSTQQYGSNVPNMHNGMNQQAYAYPATAAAPMIGYPMPTGYSQ
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}.
uniprot
proteins
mass_dalton
69148
uniprot
proteins
mutagenesis
MUTAGEN 53; /note="K->R: Abolishes sumoylation, abolishes interaction with HDAC1, increases TP53 coactivation and promotes polyubiquitination."; /evidence="ECO:0000269|PubMed:17369852, ECO:0000269|PubMed:19995069"; MUTAGEN 55; /note="E->A: Abolishes sumoylation."; /evidence="ECO:0000269|PubMed:17369852"; MUTAGEN 144; /note="K->R: Abolishes RNA helicase activity."; /evidence="ECO:0000269|PubMed:17011493"; MUTAGEN 403; /note="R->L: Binds to the tau stem-loop-containing RNA. Inhibits tau exon 10 inclusion and RNA cleavage. Does not inhibit interaction with RBM4."; /evidence="ECO:0000269|PubMed:21343338
uniprot
proteins
post_translational_modification
PTM: Arg-502 is dimethylated, probably to asymmetric dimethylarginine.; PTM: Sumoylated; sumoylation, promoted by PIAS1, promotes interaction with HDAC1 and transcriptional repression activity. Sumoylation also significantly increases stability, and reduces polyubiquitination. {ECO:0000269|PubMed:17369852, ECO:0000269|PubMed:19995069}.; PTM: Polyubiquitinated, leading to proteasomal degradation. {ECO:0000269|PubMed:19995069}.; PTM: Weakly phosphorylated in the G1/S phase of the cell cycle and much more at G2/M, especially at Thr and Tyr residues. {ECO:0000269|PubMed:22034099}.
uniprot
proteins
protein_family
DDX5/DBP2 subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
10409727
uniprot
proteins
pubmed
10648785
uniprot
proteins
pubmed
10837141
uniprot
proteins
pubmed
11250900
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
12527917
uniprot
proteins
pubmed
12595555
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15298701
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15660129
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17011493
uniprot
proteins
pubmed
17369852
uniprot
proteins
pubmed
17932509
uniprot
proteins
pubmed
17960593
uniprot
proteins
pubmed
18279852
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18829551
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19718048
uniprot
proteins
pubmed
1996094
uniprot
proteins
pubmed
19995069
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20941364
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21343338
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22034099
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2349099
uniprot
proteins
pubmed
24509260
uniprot
proteins
pubmed
2451786
uniprot
proteins
pubmed
24644279
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25452582
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26030138
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
614
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22034099}. Nucleus, nucleolus {ECO:0000269|PubMed:10837141, ECO:0000269|PubMed:1996094}. Nucleus speckle {ECO:0000269|PubMed:24644279}. Cytoplasm {ECO:0000269|PubMed:22034099}. Note=During the G0 phase, predominantly located in the nucleus. Cytoplasmic levels increase during the G1/S phase. During the M phase, located at the vicinity of the condensed chromosomes. At G1, localizes in the cytoplasm. {ECO:0000269|PubMed:22034099}.
uniprot
proteins