TRIM6
entrez
117854
canonical
uniprot
Q9C030
canonical
ensembl
ENSG00000121236
resolver
ensp
ENSP00000278302
resolver
ensp
ENSP00000369440
resolver
ensp
ENSP00000421079
resolver
ensp
ENSP00000421802
resolver
genesymbol
TRIM6
resolver
genesymbol_syn
RNF89
resolver
hgnc
HGNC:16277
resolver
uniprot
A8K2A7
resolver
uniprot
B4DDQ5
resolver
uniprot
Q86WZ8
resolver
uniprot
Q9HCR1
resolver
uniprot_entry
TRIM6_HUMAN
resolver
uniprot_sec
A8K2A7
resolver
uniprot_sec
B4DDQ5
resolver
uniprot_sec
Q86WZ8
resolver
uniprot_sec
Q9HCR1
resolver
amino_acid_sequence
MTSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQPGNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERSQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDCSVLGSQHFSSGKHYWEVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVIPMTLRRPSS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway (PubMed:24882218, PubMed:31694946). In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response (PubMed:24882218). Also ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Promotes the association of unanchored 'Lys-48'-polyubiquitin chains with DHX16 leading to enhanced RIGI-mediated innate antiviral immune response (PubMed:35263596). {ECO:0000250|UniProtKB:Q8BGE7, ECO:0000269|PubMed:24882218, ECO:0000269|PubMed:31694946, ECO:0000269|PubMed:35263596}.; FUNCTION: (Microbial infection) Ubiquitinates ebolavirus protein VP35 leading to enhanced viral transcriptase activity. {ECO:0000269|PubMed:28679761, ECO:0000269|PubMed:35533195}.
uniprot
proteins
mass_dalton
56400
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="C->A: Abolishes binding of polyubiquitin to IKBKE."; /evidence="ECO:0000269|PubMed:24882218"; MUTAGEN 121; /note="R->E: Reduced higher order self-association and association with TRIM5."; /evidence="ECO:0000269|PubMed:21680743
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8BGE7}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11013086
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17156811
uniprot
proteins
pubmed
21680743
uniprot
proteins
pubmed
24882218
uniprot
proteins
pubmed
27622505
uniprot
proteins
pubmed
28679761
uniprot
proteins
pubmed
31694946
uniprot
proteins
pubmed
35263596
uniprot
proteins
pubmed
35533195
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:24882218, ECO:0000269|PubMed:35263596}.
uniprot
proteins