Chordc1
entrez
66917
canonical
uniprot
Q9D1P4
canonical
ensembl
ENSMUSG00000001774
resolver
ensp
ENSMUSP00000001825
resolver
enst
ENSMUST00000001825
resolver
genesymbol
Chordc1
resolver
genesymbol_syn
Chp1
resolver
genesymbol_syn
Morgana
resolver
uniprot
Q9CSI5
resolver
uniprot_entry
CHRD1_MOUSE
resolver
uniprot_sec
Q9CSI5
resolver
amino_acid_sequence
MALLCYNRGCGQRFDPEANSDDACTYHPGVPVFHDALKGWSCCKRRTTDFSDFLSIVGCTKGRHNSEKPPEPVKPEVKTTEKKELSELKPKFQEHIIQAPKPVEAIKRPSPDEPMTNLELKISASLKQALDKLKLSSGSEEDKKEEDSDEIKIGTSCKNGGCSKTYQGLQSLEEVCVYHSGVPIFHEGMKYWSCCRRKTSDFNTFLAQEGCTRGKHVWTKKDAGKKVVPCRHDWHQTGGEVTISVYAKNSLPELSQVEANSTLLNVHIVFEGEKEFHQNVKLWGVIDVKRSYVTMTATKIEITMRKAEPMQWASLELPTTKKQEKQKDIAD
uniprot
proteins
function
FUNCTION: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:16083881). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:16083881). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (By similarity). Involved in stress response (PubMed:20493909). Prevents tumorigenesis (By similarity). {ECO:0000250|UniProtKB:Q9UHD1, ECO:0000269|PubMed:16083881, ECO:0000269|PubMed:20230755, ECO:0000269|PubMed:20493909}.
uniprot
proteins
mass_dalton
37351
uniprot
proteins
pubmed
12965203
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15642353
uniprot
proteins
pubmed
16083881
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17253150
uniprot
proteins
pubmed
20230755
uniprot
proteins
pubmed
20493909
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
331
uniprot
proteins