Aars2
entrez
301254
canonical
uniprot
D3ZX08
canonical
ensembl
ENSRNOG00000025808
resolver
ensp
ENSRNOP00000104177
resolver
genesymbol
Aars2
resolver
uniprot_entry
SYAM_RAT
resolver
amino_acid_sequence
MAASVAAAAGRLRRAIGRSCPWQRFSTEPHPPHGAAVRDAFLSFFRDRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVANSQKCVRAGGRHNDLEDVGRDLSHHTFFEMLGNWAFGGEYFKKEACSMAWELLTQVYGIPEDRLWVSYFSGDSKTGLDPDLETRDIWLSLGVPASRVLSFGLQENFWEMGDTGPCGPCTEIHYDLAGGMGPPQLVELWNLVFMQHYREADGSLHLLPQQHVDTGMGLERLVAVLQGKHSTYDTDLFSPLLDAIHQSCRVPPYSGRVGAADEGRIDTAYRVVADHIRTLSVCIADGVSPGMSGAPLVLRRILRRAVRYSTEVLQAPPGFLGNLVPVVVATLGAAYPELQKNSVKVLIWEIANLVSEDEAAFLASLQRGRRIIDRTVKRLGPSDLFPAEVAWSLSLSGNLGIPLDLVQLMLEEKGVKLDTAGLEQLAQKEAQHRAQQAEAAQEEGLCLDVHALEELHRQGIPTTDDSPKYNYSLRPNGDYEFGLCEAQVLQLYSETGTAVASVGEGQRCGLLLDRTNFYAEQGGQASDRGYLIRTGQQDVLFPVARAQVCGGFILHEAMAPECLQVGDRVQLYVDKAWRMGCMVKHTATHLLNWALRQTLGPTTEQRGSHLNPERLRFDVATQTPLTTEQLRTVESYVQEAVGQDKPVYMEEVPLAHTARIPGLRSLDEVYPDPVRVVSVGVPVAQALAPASQAALQTSVELCCGTHLLSTGAVGDLVIIGDRQLVKGITRLLAITGEQAQQAREVGQSLSQEVEVASERLSRGSRDLLEAHRLSKDIGRLIEFTESAVIPQWQRQEQQTTLKMLQRRANTAIRKLEKSQATEKSQELLKRHSEGPLIVDTVSAQSLSVLVKVVRQLCKQAPSMSVLLLSPQPTGSVLCACQVAQGATPTFTAEAWALAVCSHMGGKAWGSPVIAQGTGHTADLEAALRTARAYALNQL
uniprot
proteins
ec_number
6.-.-.-
uniprot
proteins
ec_number
6.1.1.7
uniprot
proteins
function
FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as CGAS (By similarity). Acts as an inhibitor of cGAS/STING signaling by catalyzing lactylation of CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (By similarity). {ECO:0000255|HAMAP-Rule:MF_03133}.
uniprot
proteins
mass_dalton
107806
uniprot
proteins
protein_family
Class-II aminoacyl-tRNA synthetase family
uniprot
proteins
sequence_length
985
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion.
uniprot
proteins