ANKRD2
entrez
26287
canonical
uniprot
Q9GZV1
canonical
ensembl
ENSG00000165887
resolver
ensp
ENSP00000298808
resolver
ensp
ENSP00000306163
resolver
ensp
ENSP00000359689
resolver
ensp
ENSP00000403114
resolver
enst
ENST00000370655
resolver
enst
ENST00000455090
resolver
genesymbol
ANKRD2
resolver
genesymbol_syn
ARPP
resolver
hgnc
HGNC:495
resolver
uniprot
A0A0A0MRN9
resolver
uniprot
Q3B778
resolver
uniprot
Q5T456
resolver
uniprot
Q5T457
resolver
uniprot
Q70EZ9
resolver
uniprot
Q8WUD7
resolver
uniprot
Q96MG0
resolver
uniprot
Q9NQC9
resolver
uniprot_entry
A0A0A0MRN9_HUMAN
resolver
uniprot_entry
ANKR2_HUMAN
resolver
uniprot_entry
Q5T457_HUMAN
resolver
uniprot_sec
Q3B778
resolver
uniprot_sec
Q5T456
resolver
uniprot_sec
Q70EZ9
resolver
uniprot_sec
Q8WUD7
resolver
uniprot_sec
Q96MG0
resolver
uniprot_sec
Q9NQC9
resolver
amino_acid_sequence
MAKAPSWAGVGALAYKAPEALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRGDARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ
uniprot
proteins
function
FUNCTION: Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. {ECO:0000269|PubMed:21737686, ECO:0000269|PubMed:22016770}.
uniprot
proteins
mass_dalton
39859
uniprot
proteins
mutagenesis
MUTAGEN 99; /note="S->A: Loss of interaction and phosphorylation by PKB/AKT2, loss of translocation to the nucleus and loss of function in myocyte differentiation."; /evidence="ECO:0000269|PubMed:21737686
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-99 by PKB/AKT2 in response to oxidative stress induces translocation to the nucleus and negatively regulates myoblast differentiation. {ECO:0000269|PubMed:21737686}.
uniprot
proteins
pubmed
10873377
uniprot
proteins
pubmed
11444853
uniprot
proteins
pubmed
11453652
uniprot
proteins
pubmed
14583192
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15136035
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21737686
uniprot
proteins
pubmed
22016770
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Note=In the sarcoplasm of differentiated striated muscle cells, where it is cytosolic and enriched in the I band. In nucleus and PML bodies of proliferating and undifferentiated myoblasts. Associates with the euchromatin in the nucleus of myocytes upon muscle stress.
uniprot
proteins