Cox7a1
entrez
12865
canonical
uniprot
P56392
canonical
ensembl
ENSMUSG00000074218
resolver
ensp
ENSMUSP00000096193
resolver
ensp
ENSMUSP00000146960
resolver
enst
ENSMUST00000098594
resolver
enst
ENSMUST00000208441
resolver
genesymbol
Cox7a1
resolver
genesymbol_syn
Cox7a
resolver
genesymbol_syn
Cox7ah
resolver
uniprot
A0A140LIU4
resolver
uniprot
Q792A4
resolver
uniprot_entry
A0A140LIU4_MOUSE
resolver
uniprot_entry
CX7A1_MOUSE
resolver
uniprot_entry
Q792A4_MOUSE
resolver
amino_acid_sequence
MRALRVSQALVRSFSSSTRSHLENRVAEKQKLFQADNDLPVHLKGGGMDNVLYRLTMTLTLGGTAYCLYCLGWASFPHKK
uniprot
proteins
function
FUNCTION: Component of the mitochondrial respiratory complex IV (CIV, also named cytochrome c oxidase complex), the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:22119795, PubMed:22869013). The CIV complex is the component of the respiratory chain that catalyzes the reduction of oxygen to water (By similarity). Acts as an assembly factor that specifically drives the homodimerization of CIV complexes, mediating the formation of mitochondrial respiratory supercomplexes (respirasomes) containing two CIV: supercomplxes with two molecules of CIV show improved activity (By similarity). Despite being highly expressed in brown adipose tissue, not required for thermogenesis (PubMed:26635001). {ECO:0000250|UniProtKB:P10174, ECO:0000250|UniProtKB:Q08CE7, ECO:0000269|PubMed:22119795, ECO:0000269|PubMed:22869013, ECO:0000269|PubMed:26635001}.
uniprot
proteins
mass_dalton
8986
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000269|PubMed:22119795, ECO:0000269|PubMed:22869013}.
uniprot
proteins
protein_family
Cytochrome c oxidase VIIa family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22119795
uniprot
proteins
pubmed
22869013
uniprot
proteins
pubmed
26635001
uniprot
proteins
pubmed
9615220
uniprot
proteins
sequence_length
80
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07470}; Single-pass membrane protein {ECO:0000250|UniProtKB:P07470}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..75; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P07470
uniprot
proteins