Ppp4r3a
entrez
68734
canonical
uniprot
Q6P2K6
canonical
ensembl
ENSMUSG00000041846
resolver
ensp
ENSMUSP00000041667
resolver
ensp
ENSMUSP00000129654
resolver
ensp
ENSMUSP00000315276
resolver
ensp
ENSMUSP00000347827
resolver
enst
ENSMUST00000163095
resolver
genesymbol
Ppp4r3a
resolver
genesymbol_syn
Kiaa2010
resolver
genesymbol_syn
Pp4r3a
resolver
genesymbol_syn
Smek1
resolver
uniprot
E9Q481
resolver
uniprot
Q3UF79
resolver
uniprot
Q69Z35
resolver
uniprot
Q80VS2
resolver
uniprot
Q8BKP7
resolver
uniprot_entry
E9Q481_MOUSE
resolver
uniprot_entry
P4R3A_MOUSE
resolver
uniprot_sec
Q3UF79
resolver
uniprot_sec
Q69Z35
resolver
uniprot_sec
Q80VS2
resolver
uniprot_sec
Q8BKP7
resolver
amino_acid_sequence
MTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVDITQDLVDESEEERFDDMSSPGLELPSCELSRLEEIAELVASSLPSPLRREKLALALENEGYIKKLLELFHVCEDLENIEGLHHLYEIIKGIFLLNRTALFEVMFSEECIMDVIGCLEYDPTLSQPRKHREFLTKTAKFKEVIPISDPELKQKIHQTYRVQYIQDMVLPTPSVFEENMLSTLHSFIFFNKVEIVGMLQEDEKFLTDLFAQLTDEATDEEKRQELVNFLKEFCAFSQTLQPQNRDAFFKTLSNMGILPALEVILGMDDTQVRSAATDIFSYLVEYNPSMVREFVMQEAQQNDDDILLINLIIEHMICDTDPELGGAVQLMGLLRTLVDPENMLATANKTEKTEFLGFFYKHCMHVLTAPLLANTTEDKPSKDDFQTAQLLALVLELLTFCVEHHTYHIKNYIINKDILRRVLVLMASKHAFLALCALRFKRKIIGLKDEFYNRYIMKSFLFEPVVKAFLNNGSRYNLMNSAIIEMFEFIRVEDIKSLTAHVIENYWKALEDVDYVQTFKGLKLRFEQQRERQDNPKLDSMRSILRNHRYRRDARTLEDEEEMWFNTDEDDMEDGEAVVSPSDKTKNDDDIMDPISKFMERKKLKESEEKEVLLKTNLSGRQSPSFKLSLSSGTKTNLTSQSSATSLPGSPGSPGSPGSPGSPGSVPKSTSQTAAITTKGGLVGLVDYPDDDEDDDEDEDKEDTLPVSKKAKFES
uniprot
proteins
function
FUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
93842
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF(FBXO42) complex; leading to proteasomal degradation. {ECO:0000250|UniProtKB:P60510}.
uniprot
proteins
protein_family
SMEK family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
820
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions (By similarity). {ECO:0000250}.
uniprot
proteins