SIMC1
entrez
375484
canonical
uniprot
Q8NDZ2
canonical
ensembl
ENSG00000170085
resolver
ensp
ENSP00000331311
resolver
ensp
ENSP00000342075
resolver
ensp
ENSP00000406571
resolver
ensp
ENSP00000410552
resolver
genesymbol
SIMC1
resolver
genesymbol_syn
C5orf25
resolver
genesymbol_syn
PLEIAD
resolver
hgnc
HGNC:24779
resolver
uniprot
B4DRM7
resolver
uniprot
F6R0L0
resolver
uniprot
J3KQQ8
resolver
uniprot
Q6NXN8
resolver
uniprot
Q6ZTU4
resolver
uniprot
Q8IZ15
resolver
uniprot
R9TJD7
resolver
uniprot_entry
B4DRM7_HUMAN
resolver
uniprot_entry
SIMC1_HUMAN
resolver
uniprot_sec
F6R0L0
resolver
uniprot_sec
J3KQQ8
resolver
uniprot_sec
Q6NXN8
resolver
uniprot_sec
Q6ZTU4
resolver
uniprot_sec
Q8IZ15
resolver
uniprot_sec
R9TJD7
resolver
amino_acid_sequence
MAPASASGEDLRKLPTMAEVNGEQDFIDLTRETRPRTKDRSGLYVIDLTRAEGENRPIATLDLTLEPVTPSQKEPTSLQTCASLSGKAVMEGHVDRSSQPTARRIINSDPVDLDLVEENTFVGPPPATSISGGSVYPTEPNCSSATFTGNLSFLASLQLSSDVSSLSPTSNNSRSSSSSSNQKAPLPCPQQDVSRPPQALPCPLRPLPCPPRASPCPPRASSCPPRALSCPSQTMQCQLPALTHPPQEVPCPRQNIPGPPQDSLGLPQDVPGLPQSILHPQDVAYLQDMPRSPGDVPQSPSDVSPSPDAPQSPGGMPHLPGDVLHSPGDMPHSSGDVTHSPRDIPHLPGDRPDFTQNDVQNRDMPMDISALSSPSCSPSPQSETPLEKVPWLSVMETPARKEISLSEPAKPGSAHVQSRTPQGGLYNRPCLHRLKYFLRPPVHHLFFQTLIPDKDTRENKGQKLEPIPHRRLRMVTNTIEENFPLGTVQFLMDFVSPQHYPPREIVAHIIQKILLSGSETVDVLKEAYMLLMKIQQLHPANAKTVEWDWKLLTYVMEEEGQTLPGRVLFLRYVVQTLEDDFQQTLRRQRQHLQQSIANMVLSCDKQPHNVRDVIKWLVKAVTEDGLTQPPNGNQTSSGTGILKASSSHPSSQPNLTKNTNQLIVCQLQRMLSIAVEVDRTPTCSSNKIAEMMFGFVLDIPERSQREMFFTTMESHLLRCKVLEIIFLHSCETPTRLPLSLAQALYFLNNSTSLLKCQSDKSQWQTWDELVEHLQFLLSSYQHVLREHLRSSVIDRKDLIIKRIKPKPQQGDDITVVDVEKQIEAFRSRLIQMLGEPLVPQLQDKVHLLKLLLFYAADLNPDAEPFQKGWSGS
uniprot
proteins
function
FUNCTION: Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SLF2 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication. {ECO:0000269|PubMed:36373674}.; FUNCTION: [Isoform 1]: Inhibits the protease activity of CAPN3. {ECO:0000269|PubMed:23707407}.; FUNCTION: [Isoform 5]: Inhibits the protease activity of CAPN3. {ECO:0000269|PubMed:23707407}.
uniprot
proteins
mass_dalton
96838
uniprot
proteins
mutagenesis
MUTAGEN 473; /note="R->D: Loss of interaction with SMC6; when associated with A-477, K-480 and K-481."; /evidence="ECO:0000269|PubMed:36373674"; MUTAGEN 477; /note="N->A: Loss of interaction with SMC6; when associated with D-473, K-480 and K-481."; /evidence="ECO:0000269|PubMed:36373674"; MUTAGEN 480; /note="E->K: Loss of interaction with SMC6; when associated with D-473, A-477 and K-481."; /evidence="ECO:0000269|PubMed:36373674"; MUTAGEN 481; /note="E->K: Loss of interaction with SMC6; when associated with D-473, A-477 and K-480."; /evidence="ECO:0000269|PubMed:36373674
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
23086935
uniprot
proteins
pubmed
23707407
uniprot
proteins
pubmed
36373674
uniprot
proteins
sequence_length
872
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, PML body {ECO:0000269|PubMed:36373674}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:23707407}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:23707407}.
uniprot
proteins