ATP10A
entrez
57194
canonical
uniprot
O60312
canonical
ensembl
ENSG00000206190
resolver
ensp
ENSP00000349325
resolver
ensp
ENSP00000450480
resolver
genesymbol
ATP10A
resolver
genesymbol_syn
ATP10C
resolver
genesymbol_syn
ATPVA
resolver
genesymbol_syn
ATPVC
resolver
genesymbol_syn
KIAA0566
resolver
hgnc
HGNC:13542
resolver
uniprot
Q4G0S9
resolver
uniprot
Q969I4
resolver
uniprot_entry
AT10A_HUMAN
resolver
uniprot_sec
Q4G0S9
resolver
uniprot_sec
Q969I4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited under hypotonic conditions. {ECO:0000269|PubMed:29599178}.
uniprot
proteins
amino_acid_sequence
MEREPAGTEEPGPPGRRRRREGRTRTVRSNLLPPPGAEDPAAGAAKGERRRRRGCAQHLADNRLKTTKYTLLSFLPKNLFEQFHRPANVYFVFIALLNFVPAVNAFQPGLALAPVLFILAITAFRDLWEDYSRHRSDHKINHLGCLVFSREEKKYVNRFWKEIHVGDFVRLRCNEIFPADILLLSSSDPDGLCHIETANLDGETNLKRRQVVRGFSELVSEFNPLTFTSVIECEKPNNDLSRFRGCIIHDNGKKAGLYKENLLLRGCTLRNTDAVVGIVIYAGHETKALLNNSGPRYKRSKLERQMNCDVLWCVLLLVCMSLFSAVGHGLWIWRYQEKKSLFYVPKSDGSSLSPVTAAVYSFLTMIIVLQVLIPISLYVSIEIVKACQVYFINQDMQLYDEETDSQLQCRALNITEDLGQIQYIFSDKTGTLTENKMVFRRCTVSGVEYSHDANAQRLARYQEADSEEEEVVPRGGSVSQRGSIGSHQSVRVVHRTQSTKSHRRTGSRAEAKRASMLSKHTAFSSPMEKDITPDPKLLEKVSECDKSLAVARHQEHLLAHLSPELSDVFDFFIALTICNTVVVTSPDQPRTKVRVRFELKSPVKTIEDFLRRFTPSCLTSGCSSIGSLAANKSSHKLGSSFPSTPSSDGMLLRLEERLGQPTSAIASNGYSSQADNWASELAQEQESERELRYEAESPDEAALVYAARAYNCVLVERLHDQVSVELPHLGRLTFELLHTLGFDSVRKRMSVVIRHPLTDEINVYTKGADSVVMDLLQPCSSVDARGRHQKKIRSKTQNYLNVYAAEGLRTLCIAKRVLSKEEYACWLQSHLEAESSLENSEELLFQSAIRLETNLHLLGATGIEDRLQDGVPETISKLRQAGLQIWVLTGDKQETAVNIAYACKLLDHDEEVITLNATSQEACAALLDQCLCYVQSRGLQRAPEKTKGKVSMRFSSLCPPSTSTASGRRPSLVIDGRSLAYALEKNLEDKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRSKLKAMTLAIGDGANDVSMIQVADVGVGISGQEGMQAVMASDFAVPKFRYLERLLILHGHWCYSRLANMVLYFFYKNTMFVGLLFWFQFFCGFSASTMIDQWYLIFFNLLFSSLPPLVTGVLDRDVPANVLLTNPQLYKSGQNMEEYRPRTFWFNMADAAFQSLVCFSIPYLAYYDSNVDLFTWGTPIVTIALLTFLLHLGIETKTWTWLNWITCGFSVLLFFTVALIYNASCATCYPPSNPYWTMQALLGDPVFYLTCLMTPVAALLPRLFFRSLQGRVFPTQLQLARQLTRKSPRRCSAPKETFAQGRLPKDSGTEHSSGRTVKTSVPLSQPSWHTQQPVCSLEASGEPSTVDMSMPVREHTLLEGLSAPAPMSSAPGEAVLRSPGGCPEESKVRAASTGRVTPLSSLFSLPTFSLLNWISSWSLVSRLGSVLQFSRTEQLADGQAGRGLPVQPHSGRSGLQGPDHRLLIGASSRRSQ
uniprot
proteins
ec_number
7.6.2.1
uniprot
proteins
function
FUNCTION: Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane (PubMed:25947375, PubMed:29599178, PubMed:30530492). Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking (PubMed:29599178). Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix (PubMed:25947375, PubMed:29599178). Has low flippase activity toward glucosylceramide (GlcCer) (PubMed:30530492). {ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:29599178, ECO:0000269|PubMed:30530492}.
uniprot
proteins
mass_dalton
167688
uniprot
proteins
mutagenesis
MUTAGEN 98..99; /note="NF->QA: Decreases PC-flipping activity."; /evidence="ECO:0000269|PubMed:30530492"; MUTAGEN 203; /note="E->Q: Impairs PC-flipping activity."; /evidence="ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:29599178, ECO:0000269|PubMed:30530492
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated at the conserved aspartate of the P-type ATPase signature sequence. {ECO:0000250|UniProtKB:O94823}.
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IV subfamily
uniprot
proteins
pubmed
11326269
uniprot
proteins
pubmed
11353404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
21914794
uniprot
proteins
pubmed
25947375
uniprot
proteins
pubmed
26637798
uniprot
proteins
pubmed
29599178
uniprot
proteins
pubmed
30530492
uniprot
proteins
pubmed
9628581
uniprot
proteins
sequence_length
1499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:30530492}; Multi-pass membrane protein {ECO:0000269|PubMed:21914794}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25947375}. Note=Exit from the endoplasmic reticulum requires the presence of CDC50A, but not that of CDC50B.
uniprot
proteins
transmembrane_region
TRANSMEM 87..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 111..128; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 310..332; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 363..384; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1088..1108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1120..1140; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1171..1192; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1200..1222; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1229..1249; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1268..1292; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins