Jph1
entrez
57339
canonical
uniprot
Q9ET80
canonical
ensembl
ENSMUSG00000042686
resolver
ensp
ENSMUSP00000039072
resolver
ensp
ENSMUSP00000204776
resolver
enst
ENSMUST00000038382
resolver
genesymbol
Jph1
resolver
genesymbol_syn
Jp1
resolver
uniprot
Q0VB08
resolver
uniprot
Q9EQZ3
resolver
uniprot_entry
JPH1_MOUSE
resolver
uniprot_sec
Q0VB08
resolver
uniprot_sec
Q9EQZ3
resolver
amino_acid_sequence
MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGVYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLRTSLASLRSEQSNGSVLHEAAAAAADSPAGTRGGFVLNFHADTELGKKKGGLFRRGSLLGSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDATTTETYMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNILVRGIRKQLIPIRNTKTREKVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAADQAALAARQECDIARAVARELSPDFYQPGPDYIKQRCQEGGDIKENPEEKVLEKPPSPKESPHFYRKGTTPPRSPESSPKQSHSPQPSSPEPSKKQNPSPGARLSQDKQSLAEEQVTAFVNKPSMSKAPAKELGASVSKYSGRHHVPNPSNGELHSQYHGYYVKLNTPQHPPEDREDDRGVSQSSSALVPRPSPNKWGPPKSVTKPVAKESKTEPKAKKSELAIPKNPASNDTCPSLEKEANSGPNSIMIVLVMLLNIGLAILFVHFLT
uniprot
proteins
function
FUNCTION: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. {ECO:0000269|PubMed:11535622, ECO:0000269|PubMed:12135771, ECO:0000269|PubMed:12729900}.
uniprot
proteins
mass_dalton
71905
uniprot
proteins
protein_family
Junctophilin family
uniprot
proteins
pubmed
10949023
uniprot
proteins
pubmed
11535622
uniprot
proteins
pubmed
12135771
uniprot
proteins
pubmed
12729900
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
660
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands.
uniprot
proteins
transmembrane_region
TRANSMEM 639..659; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins