ECRG4
entrez
84417
canonical
uniprot
Q9H1Z8
canonical
ensembl
ENSG00000119147
resolver
ensp
ENSP00000238044
resolver
ensp
ENSP00000386421
resolver
ensp
ENSP00000388664
resolver
enst
ENST00000238044
resolver
enst
ENST00000409944
resolver
genesymbol
ECRG4
resolver
genesymbol_syn
C2orf40
resolver
hgnc
HGNC:24642
resolver
uniprot
B8ZZE5
resolver
uniprot
D3DVK2
resolver
uniprot_entry
AUGN_HUMAN
resolver
uniprot_entry
B8ZZE5_HUMAN
resolver
uniprot_sec
D3DVK2
resolver
amino_acid_sequence
MAASPARPAVLALTGLALLLLLCWGPGGISGNKLKLMLQKREAPVPTKTKVAVDENKAKEFLGSLKRQKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDITYWLNRDRNGHEYYGDYYQRHYDEDSAIGPRSPYGFRHGASVNYDDY
uniprot
proteins
function
FUNCTION: Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (By similarity). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:D4A540}.
uniprot
proteins
mass_dalton
17183
uniprot
proteins
protein_family
Augurin family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
21349154
uniprot
proteins
sequence_length
148
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21349154}. Cytoplasm {ECO:0000269|PubMed:21349154}. Apical cell membrane {ECO:0000269|PubMed:21349154}.
uniprot
proteins