NUDT16L1
entrez
84309
canonical
uniprot
Q9BRJ7
canonical
ensembl
ENSG00000168101
resolver
ensp
ENSP00000306670
resolver
ensp
ENSP00000458144
resolver
ensp
ENSP00000464821
resolver
ensp
ENSP00000466854
resolver
ensp
ENSP00000468346
resolver
ensp
ENSP00000530971
resolver
ensp
ENSP00000665203
resolver
enst
ENST00000586252
resolver
enst
ENST00000586536
resolver
genesymbol
NUDT16L1
resolver
genesymbol_syn
SDOS
resolver
genesymbol_syn
TIRR
resolver
hgnc
HGNC:28154
resolver
uniprot
B2RD96
resolver
uniprot
K7ENA3
resolver
uniprot
Q8NAI2
resolver
uniprot
W4VSQ8
resolver
uniprot_entry
B2RD96_HUMAN
resolver
uniprot_entry
K7ENA3_HUMAN
resolver
uniprot_entry
TIRR_HUMAN
resolver
uniprot_entry
W4VSQ8_HUMAN
resolver
uniprot_sec
Q8NAI2
resolver
amino_acid_sequence
MSTAAVPELKQISRVEAMRLGPGWSHSCHAMLYAANPGQLFGRIPMRFSVLMQMRFDGLLGFPGGFVDRRFWSLEDGLNRVLGLGLGCLRLTEADYLSSHLTEGPHRVVAHLYARQLTLEQLHAVEISAVHSRDHGLEVLGLVRVPLYTQKDRVGGFPNFLSNAFVSTAKCQLLFALKVLNMMPEEKLVEALAAATEKQKKALEKLLPASS
uniprot
proteins
function
FUNCTION: Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299). {ECO:0000269|PubMed:18820299, ECO:0000269|PubMed:28241136}.
uniprot
proteins
mass_dalton
23338
uniprot
proteins
mutagenesis
MUTAGEN 10; /note="K->E: Abolishes interaction with TP53BP1."; /evidence="ECO:0000269|PubMed:28241136"; MUTAGEN 151; /note="K->E: Still able to interact with TP53BP1."; /evidence="ECO:0000269|PubMed:28241136
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
protein_family
TIRR subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18820299
uniprot
proteins
pubmed
21070968
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
28241136
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28241136}.
uniprot
proteins