Gabrb1
entrez
25450
canonical
uniprot
P15431
canonical
ensembl
ENSRNOG00000002327
resolver
ensembl
ENSRNOG00055005200
resolver
ensembl
ENSRNOG00060022022
resolver
ensembl
ENSRNOG00065019927
resolver
ensp
ENSRNOP00000003170
resolver
ensp
ENSRNOP00055006320
resolver
ensp
ENSRNOP00060031445
resolver
ensp
ENSRNOP00065026870
resolver
enst
ENSRNOT00000003170
resolver
enst
ENSRNOT00055008351
resolver
enst
ENSRNOT00060038152
resolver
enst
ENSRNOT00065033579
resolver
genesymbol
Gabrb1
resolver
genesymbol_syn
Gabrb-1
resolver
uniprot_entry
GBRB1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Potentiated by histamine. {ECO:0000250|UniProtKB:P63138}.
uniprot
proteins
amino_acid_sequence
MWTVQNRESLGLLSFPVMVAMVCCAHSSNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTGVSDPKATMYSYDSASIQYRKPLSSREGFGRGLDRHGVPGKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
uniprot
proteins
function
FUNCTION: Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:1977069). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:30044221). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:1977069). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed:1977069). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity). {ECO:0000250|UniProtKB:P28472, ECO:0000269|PubMed:1977069, ECO:0000269|PubMed:30044221}.
uniprot
proteins
mass_dalton
54072
uniprot
proteins
protein_family
GABRB1 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
1977069
uniprot
proteins
pubmed
2548852
uniprot
proteins
pubmed
30044221
uniprot
proteins
sequence_length
474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P08220}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08220}. Cell membrane {ECO:0000250|UniProtKB:P08220}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08220}.
uniprot
proteins
transmembrane_region
TRANSMEM 246..267; /note="Helical"; /evidence="ECO:0000305"; TRANSMEM 271..293; /note="Helical"; /evidence="ECO:0000305"; TRANSMEM 305..327; /note="Helical"; /evidence="ECO:0000305"; TRANSMEM 452..473; /note="Helical"; /evidence="ECO:0000305
uniprot
proteins