Hspb6
entrez
192245
canonical
uniprot
P97541
canonical
ensembl
ENSRNOG00000020922
resolver
ensembl
ENSRNOG00055031755
resolver
ensembl
ENSRNOG00060030846
resolver
ensembl
ENSRNOG00065032446
resolver
ensp
ENSRNOP00000028401
resolver
ensp
ENSRNOP00055045409
resolver
ensp
ENSRNOP00060044478
resolver
ensp
ENSRNOP00065045984
resolver
enst
ENSRNOT00000028401
resolver
enst
ENSRNOT00055054957
resolver
enst
ENSRNOT00060053566
resolver
enst
ENSRNOT00065055829
resolver
genesymbol
Hspb6
resolver
uniprot_entry
HSPB6_RAT
resolver
amino_acid_sequence
MEIRVPVQPSWLRRASAPLPGFSTPGRLFDQRFGEGLLEAELASLCPAAIAPYYLRAPSVALPTAQVPTDPGYFSVLLDVKHFSPEEISVKVVGDHVEVHARHEERPDEHGFIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQATPASAQASLPSPPAAK
uniprot
proteins
function
FUNCTION: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (By similarity). Seems to have versatile functions in various biological processes (By similarity). Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility (By similarity). May regulate myocardial angiogenesis implicating KDR (By similarity). Overexpression mediates cardioprotection and angiogenesis after induced damage (PubMed:15105294). Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity (By similarity). {ECO:0000250|UniProtKB:O14558, ECO:0000269|PubMed:15105294}.
uniprot
proteins
mass_dalton
17505
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="Q->E: Abolished transglutamination."; /evidence="ECO:0000269|PubMed:16385579
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked. {ECO:0000269|PubMed:8195168}.; PTM: Phosphorylated at Ser-16 by PKA and probably PKD1K; required to protect cardiomyocytes from apoptosis. {ECO:0000250|UniProtKB:O14558, ECO:0000269|PubMed:15105294}.
uniprot
proteins
protein_family
Small heat shock protein (HSP20) family
uniprot
proteins
pubmed
15105294
uniprot
proteins
pubmed
16385579
uniprot
proteins
pubmed
19646995
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8195168
uniprot
proteins
pubmed
8921906
uniprot
proteins
sequence_length
162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O14558}. Nucleus {ECO:0000250|UniProtKB:O14558}. Secreted {ECO:0000250|UniProtKB:O14558}. Note=Translocates to nuclear foci during heat shock. {ECO:0000250|UniProtKB:O14558}.
uniprot
proteins