Picalm
entrez
89816
canonical
uniprot
O55012
canonical
ensembl
ENSRNOG00000018322
resolver
ensp
ENSRNOP00000068834
resolver
ensp
ENSRNOP00000069185
resolver
ensp
ENSRNOP00000076067
resolver
ensp
ENSRNOP00000082147
resolver
enst
ENSRNOT00000084268
resolver
enst
ENSRNOT00000091470
resolver
enst
ENSRNOT00000092945
resolver
enst
ENSRNOT00000111120
resolver
genesymbol
Picalm
resolver
genesymbol_syn
CALM
resolver
genesymbol_syn
Calm
resolver
uniprot
A0A0G2JTT2
resolver
uniprot
A0A0G2JUQ5
resolver
uniprot
A0A0G2KAZ9
resolver
uniprot
A0A1B0GWY4
resolver
uniprot
A0A8I6G718
resolver
uniprot
E9PTD2
resolver
uniprot
O55011
resolver
uniprot
Q498N4
resolver
uniprot
Q66SY1
resolver
uniprot
Q66WT9
resolver
uniprot_entry
A0A0G2JTT2_RAT
resolver
uniprot_entry
A0A0G2JUQ5_RAT
resolver
uniprot_entry
A0A1B0GWY4_RAT
resolver
uniprot_entry
A0A8I6G718_RAT
resolver
uniprot_entry
PICAL_RAT
resolver
uniprot_entry
Q498N4_RAT
resolver
uniprot_entry
Q66SY1_RAT
resolver
uniprot_entry
Q66WT9_RAT
resolver
uniprot_sec
A0A0G2KAZ9
resolver
uniprot_sec
E9PTD2
resolver
uniprot_sec
O55011
resolver
amino_acid_sequence
MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHAMSAAPQVASTWGDAVDDAIPSLNPFLTKSSGDVHLPISSDVSTFTTRTPTHEMFVGFSPSPVTQPHPSAGLNVDFESVFGNKSTNVAVDSGGGLLKPTVASQNQSLPVAKLPPNKLVSDDLDSSLANLVGNLGIGNGTTKNDVSCSQPGEKKLTGGSNWQPKVAPTTAWSAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVPGAQIQFM
uniprot
proteins
function
FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF). {ECO:0000250|UniProtKB:Q13492, ECO:0000269|PubMed:11190274}.
uniprot
proteins
mass_dalton
69286
uniprot
proteins
protein_family
PICALM/SNAP91 family
uniprot
proteins
pubmed
10630373
uniprot
proteins
pubmed
11161218
uniprot
proteins
pubmed
11190274
uniprot
proteins
sequence_length
640
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13492}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q13492}. Golgi apparatus {ECO:0000250|UniProtKB:Q13492}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q13492}. Nucleus {ECO:0000250|UniProtKB:Q13492}. Note=Colocalized with clathrin in the Golgi area. Interaction with PIMREG may target PICALM to the nucleus in some cells. {ECO:0000250|UniProtKB:Q13492}.
uniprot
proteins