MOGAT2
entrez
80168
canonical
uniprot
Q3SYC2
canonical
ensembl
ENSG00000166391
resolver
ensp
ENSP00000198801
resolver
genesymbol
MOGAT2
resolver
genesymbol_syn
DC5
resolver
genesymbol_syn
DGAT2L5
resolver
hgnc
HGNC:23248
resolver
uniprot
A8K7I3
resolver
uniprot
Q3SYC1
resolver
uniprot
Q6ZQZ2
resolver
uniprot
Q86UH6
resolver
uniprot
Q9H630
resolver
uniprot_entry
MOGT2_HUMAN
resolver
uniprot_sec
A8K7I3
resolver
uniprot_sec
Q3SYC1
resolver
uniprot_sec
Q6ZQZ2
resolver
uniprot_sec
Q86UH6
resolver
uniprot_sec
Q9H630
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by oleic acid and sphingosine, while it is stimulated by phosphatidylcholine, phosphatidylserine and phosphatidic acid. {ECO:0000250|UniProtKB:Q80W94}.
uniprot
proteins
amino_acid_sequence
MVEFAPLFMPWERRLQTLAVLQFVFSFLALAEICTVGFIALLFTRFWLLTVLYAAWWYLDRDKPRQGGRHIQAIRCWTIWKYMKDYFPISLVKTAELDPSRNYIAGFHPHGVLAVGAFANLCTESTGFSSIFPGIRPHLMMLTLWFRAPFFRDYIMSAGLVTSEKESAAHILNRKGGGNLLGIIVGGAQEALDARPGSFTLLLRNRKGFVRLALTHGAPLVPIFSFGENDLFDQIPNSSGSWLRYIQNRLQKIMGISLPLFHGRGVFQYSFGLIPYRRPITTVVGKPIEVQKTLHPSEEEVNQLHQRYIKELCNLFEAHKLKFNIPADQHLEFC
uniprot
proteins
ec_number
2.3.1.20
uniprot
proteins
ec_number
2.3.1.22
uniprot
proteins
function
FUNCTION: Involved in glycerolipid synthesis and lipid metabolism (PubMed:12621063, PubMed:18768481, PubMed:27184406, PubMed:28420705). Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol (PubMed:12621063, PubMed:27184406). Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes (By similarity). Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0 at sn-2 (PubMed:12621063). Able to use 1-monoalkylglycerol (1-MAkG, 1-O-alkylglycerol) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG, 1-O-alkyl-3-acylglycerol or 1-O-alkyl-2-acylglycerol) and subsequently, with lower efficiency, may add another acyl chain producing monoalkyl-diacylglycerol (MADAG, 1-O-alkyl-2,3-diacylglycerol) (PubMed:28420705). Possesses weak but significant activity with diacylglycerol as substrate, producing triacylglycerol (triacyl-sn-glycerol) (PubMed:18768481). {ECO:0000250|UniProtKB:Q80W94, ECO:0000269|PubMed:12621063, ECO:0000269|PubMed:18768481, ECO:0000269|PubMed:27184406, ECO:0000269|PubMed:28420705}.
uniprot
proteins
mass_dalton
38196
uniprot
proteins
pathway_participation
PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis. {ECO:0000269|PubMed:27184406}.
uniprot
proteins
protein_family
Diacylglycerol acyltransferase family
uniprot
proteins
pubmed
12621063
uniprot
proteins
pubmed
12824082
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16106050
uniprot
proteins
pubmed
18768481
uniprot
proteins
pubmed
27184406
uniprot
proteins
pubmed
28420705
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12621063, ECO:0000269|PubMed:27184406}; Multi-pass membrane protein {ECO:0000269|PubMed:12621063}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27184406}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 38..59; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins