Paqr3
entrez
231474
canonical
uniprot
Q6TCG8
canonical
ensembl
ENSMUSG00000055725
resolver
ensp
ENSMUSP00000069324
resolver
ensp
ENSMUSP00000108592
resolver
ensp
ENSMUSP00000108593
resolver
ensp
ENSMUSP00000291437
resolver
ensp
ENSMUSP00000291442
resolver
enst
ENSMUST00000069453
resolver
enst
ENSMUST00000112968
resolver
enst
ENSMUST00000112969
resolver
genesymbol
Paqr3
resolver
uniprot
D3Z181
resolver
uniprot
Q0VAZ2
resolver
uniprot_entry
D3Z181_MOUSE
resolver
uniprot_entry
PAQR3_MOUSE
resolver
uniprot_entry
Q0VAZ2_MOUSE
resolver
amino_acid_sequence
MHQKLLKSAHYIELGSYQYWPVLVPRGIRLYTYEQIPVSLKDNPYITDGYRAYLPSRLCIKSLFILSNETVNIWSHLLGFFLFFTLGIYDMTSVLPSASASREDFVICSICLFCFQVCMLCSVGYHLFSCHRSEKTCRRWMALDYAGISIGILGCYVSGVFYAFYCNNYWRQVYLITVLAMILAVFFAQIHPSYLTQQWQRLRPIIFCSVSGYGVIPTLHWVWLNGGVSAPIVQDFAPRVIVMYVIALLAFLFYISKVPERYFPGQLNYLGSSHQIWHVLAVVMLYWWHQSTVYVMQYRHSKPCPDYVSHL
uniprot
proteins
function
FUNCTION: Golgi-anchored protein which modulates its interactors activities by tethering them to the Golgi apparatus (PubMed:17724343, PubMed:26311497). Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi apparatus (PubMed:17724343). Acts as a positive regulator of cholesterol biosynthesis by mediating the anchoring of the SCAP:SREBP complex in the Golgi apparatus, thereby promoting SCAP:SREBF2 complex formation, potentiating SREBF2 and SREBF1 processing and enhancing lipid synthesis (PubMed:26311497). Also regulates PPARA and PPARG functions by mediating their interaction with E3 ubiquitin ligases, such as STUB1 or HUWE1, leading to their polyubiquitination and proteasome-mediated degradation (PubMed:29331071, PubMed:35710596). {ECO:0000269|PubMed:17724343, ECO:0000269|PubMed:26311497, ECO:0000269|PubMed:29331071, ECO:0000269|PubMed:35710596}.
uniprot
proteins
mass_dalton
36212
uniprot
proteins
protein_family
ADIPOR family
uniprot
proteins
pubmed
16044242
uniprot
proteins
pubmed
17724343
uniprot
proteins
pubmed
26311497
uniprot
proteins
pubmed
29331071
uniprot
proteins
pubmed
35710596
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:17724343, ECO:0000269|PubMed:26311497}; Multi-pass membrane protein {ECO:0000269|PubMed:17724343}.
uniprot
proteins
transmembrane_region
TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 276..296; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins