HAPSTR2
entrez
389895
canonical
uniprot
A0A7P0TBJ1
canonical
ensembl
ENSG00000230707
resolver
ensp
ENSP00000506518
resolver
enst
ENST00000453380
resolver
genesymbol
HAPSTR2
resolver
hgnc
HGNC:55138
resolver
uniprot_entry
HAPR2_HUMAN
resolver
amino_acid_sequence
MEEQQKEGEAEVAEHWFSKWERQCLAEAEQEEQLPPELQEEAAAELAGLKSEKQKLWHLFQISATAVAQLYKDSGCQQQGLSMWDPFQNAAMAVTSLYKESGDAHQRSFDLGVQVGHQRRIKDVLEWVKKGRSTIRREDLISFLCGKVPPAPPPPRTPRTPPKPPTGVTSQAVATESSSSVDVDLQPFQEAIALHGLSGAMAGISMRSGDSPQDSGVASSGRRKTSFLEDDLNPFDSEELALHLDSGGIRKRTSAQCSDGITDSPIQKRNRMV
uniprot
proteins
function
FUNCTION: Together with HAPSTR1 plays a central regulatory role in the cellular response to molecular stressors, such as DNA damage, nutrient scarcity, and protein misfolding (PubMed:36631436). Regulates these multiple stress response signaling pathways by stabilizing HAPSTR1, but also independently of HAPSTR1 (PubMed:36631436). {ECO:0000269|PubMed:36631436}.
uniprot
proteins
mass_dalton
30054
uniprot
proteins
mutagenesis
MUTAGEN 116; /note="G->R: Loss of homodimerization. Loss of heterodimerization with HAPSTR1. No effect on interaction with HUWE1."; /evidence="ECO:0000269|PubMed:36631436
uniprot
proteins
protein_family
HAPSTR1 family
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
36631436
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:36631436}.
uniprot
proteins