Abcd3
entrez
25270
canonical
uniprot
P16970
canonical
ensembl
ENSRNOG00000011929
resolver
ensembl
ENSRNOG00055026677
resolver
ensembl
ENSRNOG00060002776
resolver
ensembl
ENSRNOG00065023022
resolver
ensp
ENSRNOP00000016739
resolver
ensp
ENSRNOP00000085866
resolver
ensp
ENSRNOP00055037846
resolver
ensp
ENSRNOP00060003148
resolver
ensp
ENSRNOP00065032029
resolver
enst
ENSRNOT00000016739
resolver
enst
ENSRNOT00000106914
resolver
enst
ENSRNOT00055046119
resolver
enst
ENSRNOT00060004454
resolver
enst
ENSRNOT00065039403
resolver
genesymbol
Abcd3
resolver
genesymbol_syn
Pmp70
resolver
genesymbol_syn
Pxmp1
resolver
uniprot
A0A8I6A495
resolver
uniprot_entry
A0A8I6A495_RAT
resolver
uniprot_entry
ABCD3_RAT
resolver
amino_acid_sequence
MAAFSKYLTARNSSLAGAAFLLFCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFLSRLSQILKIMVPRTFCKETGYLILIAVMLVSRTYCDVWMIQNGTLIESGIIGRSSKDFKRYLFNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTRYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLLVSGLFLTRLRRPIGKMTIMEQKYEGEYRFVNSRLITNSEEIAFYNGNKREKQTIHSVFRKLVEHLHNFIFFRFSMGFIDSIIAKYIATVVGYLVVSRPFLDLAHPRHLHSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQDKGIEGAQASPLIPGAGEIINADNIIKFDHVPLATPNGDILIQDLSFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGHLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGKEDQKKKGISDQVLKGYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKKITEDTVEFGS
uniprot
proteins
ec_number
3.1.2.-
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long- and very-long-chain fatty acyl-CoAs and probably bile acyl-CoAs from the cytosol to the peroxisome matrix for beta-oxydation. Appears to be specifically involved in the peroxisomal transport of branched-chain fatty acyl-CoAs (BCFA-CoAs) and dicarboxylic acyl CoAs (DCA-CoAs) (By similarity) (PubMed:10207018). Has fatty acyl-CoA thioesterase and ATPase activities. Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). {ECO:0000250|UniProtKB:P28288, ECO:0000269|PubMed:10207018}.
uniprot
proteins
mass_dalton
75316
uniprot
proteins
mutagenesis
MUTAGEN 277..278; /note="EE->DD: Inhibition of palmitic acid beta-oxidation."; /evidence="ECO:0000269|PubMed:10207018"; MUTAGEN 479; /note="K->A: Inhibition of palmitic acid beta-oxidation."; /evidence="ECO:0000269|PubMed:10207018
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation. {ECO:0000250|UniProtKB:P28288}.; PATHWAY: Lipid metabolism; branched-chain fatty acid metabolism. {ECO:0000250|UniProtKB:P28288}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by PEX2 during pexophagy in response to starvation, leading to its degradation. {ECO:0000250|UniProtKB:P28288}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCD family
uniprot
proteins
protein_family
Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily
uniprot
proteins
pubmed
10207018
uniprot
proteins
pubmed
10527525
uniprot
proteins
pubmed
11883951
uniprot
proteins
pubmed
1968461
uniprot
proteins
sequence_length
659
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:10207018}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P28288}.
uniprot
proteins
transmembrane_region
TRANSMEM 83..103; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P28288"; TRANSMEM 128..149; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P28288"; TRANSMEM 199..218; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P28288"; TRANSMEM 232..248; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P28288"; TRANSMEM 307..328; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P28288"; TRANSMEM 363..382; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P28288
uniprot
proteins