Comp
entrez
12845
canonical
uniprot
Q9R0G6
canonical
ensembl
ENSMUSG00000031849
resolver
ensp
ENSMUSP00000003659
resolver
enst
ENSMUST00000003659
resolver
genesymbol
Comp
resolver
uniprot
G3X8Q4
resolver
uniprot_entry
COMP_MOUSE
resolver
uniprot_sec
G3X8Q4
resolver
amino_acid_sequence
MGPTACVLVLALAILRATGQGQIPLGGDLAPQMLRELQETNAALQDVRELLRQQVKEITFLKNTVMECDACGMQPARTPGLSVRPVPLCAPGSCFPGVVCSETATGARCGPCPPGYTGNGSHCTDVNECNAHPCFPRVRCINTSPGFHCEACPPGFSGPTHEGVGLTFAKSNKQVCTDINECETGQHNCVPNSVCVNTRGSFQCGPCQPGFVGDQTSGCQRRGQHFCPDGSPSPCHEKANCVLERDGSRSCVCAVGWAGNGLLCGRDTDLDGFPDEKLRCSERQCRKDNCVTVPNSGQEDVDRDGIGDACDPDADGDGVPNEQDNCPLVRNPDQRNSDSDKWGDACDNCRSKKNDDQKDTDLDGRGDACDDDIDGDRIRNVADNCPRVPNFDQSDSDGDGVGDACDNCPQKDNPDQRDVDHDFVGDACDSDQDQDGDGHQDSRDNCPTVPNSAQQDSDHDGKGDACDDDDDNDGVPDSRDNCRLVPNPGQEDNDRDGVGDACQGDFDADKVIDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTATDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTASQVRLLWKDPRNVGWKDKTSYRWFLQHRPQVGYIRVRFYEGPELVADSNVVLDTAMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYESHRLQRV
uniprot
proteins
function
FUNCTION: Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin (PubMed:32686688). Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (By similarity). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). {ECO:0000250|UniProtKB:P35444, ECO:0000250|UniProtKB:P49747, ECO:0000269|PubMed:32686688}.
uniprot
proteins
mass_dalton
82342
uniprot
proteins
mutagenesis
MUTAGEN 65; /note="V->E: Equivalent to human variant V66E involved in CTS2 disease. Reduces secretion in tendon cells and nhibits oligomerization. Mutant mice develop inflammation and fibrosis in Achilles tendons and carpal tunnel. They show compromised regenerative capability of tendons."; /evidence="ECO:0000269|PubMed:32686688
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by metalloproteases ADAMTS4 and ADAMTS1 with ADAMTS4 showing more potent activity. {ECO:0000250|UniProtKB:P49747}.
uniprot
proteins
protein_family
Thrombospondin family
uniprot
proteins
pubmed
11052496
uniprot
proteins
pubmed
12426368
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21624478
uniprot
proteins
pubmed
32686688
uniprot
proteins
pubmed
32747625
uniprot
proteins
sequence_length
755
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:32686688}.
uniprot
proteins