NADK2
entrez
133686
canonical
uniprot
Q4G0N4
canonical
ensembl
ENSG00000152620
resolver
ensp
ENSP00000282512
resolver
ensp
ENSP00000371362
resolver
ensp
ENSP00000380499
resolver
ensp
ENSP00000422250
resolver
ensp
ENSP00000656460
resolver
enst
ENST00000506945
resolver
genesymbol
NADK2
resolver
genesymbol_syn
C5orf33
resolver
genesymbol_syn
MNADK
resolver
genesymbol_syn
NADKD1
resolver
hgnc
HGNC:26404
resolver
uniprot
B5MC93
resolver
uniprot
B7Z8V7
resolver
uniprot
F6RMV7
resolver
uniprot
Q6UTX5
resolver
uniprot
Q96NM0
resolver
uniprot_entry
B7Z8V7_HUMAN
resolver
uniprot_entry
F6RMV7_HUMAN
resolver
uniprot_entry
NADK2_HUMAN
resolver
uniprot_sec
B5MC93
resolver
uniprot_sec
Q6UTX5
resolver
uniprot_sec
Q96NM0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by NADH, NADPH and NADP(+). {ECO:0000269|PubMed:23212377}.
uniprot
proteins
amino_acid_sequence
MTCYRGFLLGSCCRVAGGRAAALRGPGAGGPAARPRLGGDGGGRRHLGQGQPRELAGCGSRADGGFRPSRVVVVAKTTRYEFEQQRYRYAELSEEDLKQLLALKGSSYSGLLERHHIHTKNVEHIIDSLRNEGIEVRLVKRREYDEETVRWADAVIAAGGDGTMLLAASKVLDRLKPVIGVNTDPERSEGHLCLPVRYTHSFPEALQKFYRGEFRWLWRQRIRLYLEGTGINPVPVDLHEQQLSLNQHNRALNIERAHDERSEASGPQLLPVRALNEVFIGESLSSRASYYEISVDDGPWEKQKSSGLNLCTGTGSKAWSFNINRVATQAVEDVLNIAKRQGNLSLPLNRELVEKVTNEYNESLLYSPEEPKILFSIREPIANRVFSSSRQRCFSSKVCVRSRCWDACMVVDGGTSFEFNDGAIASMMINKEDELRTVLLEQ
uniprot
proteins
disease_involvement
DISEASE: 2,4-dienoyl-CoA reductase deficiency (DECRD) [MIM:616034]: A rare, autosomal recessive, inborn error of polyunsaturated fatty acids and lysine metabolism, resulting in mitochondrial dysfunction. Affected individuals have a severe encephalopathy with neurologic and metabolic abnormalities beginning in early infancy. Laboratory studies show increased C10:2 carnitine levels and hyperlysinemia. {ECO:0000269|PubMed:24847004}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.1.23
uniprot
proteins
function
FUNCTION: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo. {ECO:0000269|PubMed:23212377}.
uniprot
proteins
mass_dalton
49433
uniprot
proteins
protein_family
NAD kinase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23212377
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24847004
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
442
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23212377}.
uniprot
proteins