NIP
entrez
90527
canonical
uniprot
Q1HG43
canonical
ensembl
ENSG00000140254
resolver
ensp
ENSP00000267803
resolver
ensp
ENSP00000415512
resolver
ensp
ENSP00000453569
resolver
ensp
ENSP00000453614
resolver
ensp
ENSP00000453836
resolver
ensp
ENSP00000454019
resolver
ensp
ENSP00000454084
resolver
ensp
ENSP00000480154
resolver
ensp
ENSP00000555601
resolver
ensp
ENSP00000555604
resolver
ensp
ENSP00000555605
resolver
ensp
ENSP00000555607
resolver
ensp
ENSP00000555611
resolver
ensp
ENSP00000555614
resolver
ensp
ENSP00000555615
resolver
ensp
ENSP00000555616
resolver
ensp
ENSP00000555622
resolver
ensp
ENSP00000555624
resolver
ensp
ENSP00000555634
resolver
ensp
ENSP00000596602
resolver
ensp
ENSP00000627997
resolver
ensp
ENSP00000628022
resolver
enst
ENST00000430224
resolver
enst
ENST00000613425
resolver
genesymbol
DUOXA1
resolver
genesymbol
NIP
resolver
genesymbol_syn
DUOXA1
resolver
genesymbol_syn
NIP
resolver
genesymbol_syn
NUMBIP
resolver
hgnc
HGNC:26507
resolver
uniprot
A8K9Q6
resolver
uniprot
B5M0B7
resolver
uniprot
B5M0B8
resolver
uniprot
B5M0C0
resolver
uniprot
F6R3D9
resolver
uniprot
Q8N6K9
resolver
uniprot
Q96MI4
resolver
uniprot_entry
A8K9Q6_HUMAN
resolver
uniprot_entry
B5M0B7_HUMAN
resolver
uniprot_entry
B5M0B8_HUMAN
resolver
uniprot_entry
B5M0C0_HUMAN
resolver
uniprot_entry
DOXA1_HUMAN
resolver
uniprot_entry
F6R3D9_HUMAN
resolver
uniprot_sec
Q8N6K9
resolver
uniprot_sec
Q96MI4
resolver
amino_acid_sequence
MATLGHTFPFYAGPKPTFPMDTTLASIIMIFLTALATFIVILPGIRGKTRLFWLLRVVTSLFIGAAILAVNFSSEWSVGQVSTNTSYKAFSSEWISADIGLQVGLGGVNITLTGTPVQQLNETINYNEEFTWRLGENYAEEYAKALEKGLPDPVLYLAEKFTPRSPCGLYRQYRLAGHYTSAMLWVAFLCWLLANVMLSMPVLVYGGYMLLATGIFQLLALLFFSMATSLTSPCPLHLGASVLHTHHGPAFWITLTTGLLCVLLGLAMAVAHRMQPHRLKAFFNQSVDEDPMLEWSPEEGGLLSPRYRSMADSPKSQDIPLSEASSTKAYCKEAHPKDPDCAL
uniprot
proteins
function
FUNCTION: Required for the maturation and transport of functional DUOX1 from the endoplasmic reticulum to the plasma membrane (PubMed:16651268). Recruits DUOX1 to the apical cell membrane (PubMed:39126279). {ECO:0000269|PubMed:16651268, ECO:0000269|PubMed:39126279}.
uniprot
proteins
mass_dalton
37815
uniprot
proteins
mutagenesis
MUTAGEN 84; /note="N->Q: Abolishes targeting of DUOX1 to the apical cell membrane; when associated with Q-109 and Q-121."; /evidence="ECO:0000269|PubMed:39126279"; MUTAGEN 109; /note="N->Q: Abolishes targeting of DUOX1 to the apical cell membrane; when associated with Q-84 and Q-121."; /evidence="ECO:0000269|PubMed:39126279"; MUTAGEN 121; /note="N->Q: Abolishes targeting of DUOX1 to the apical cell membrane; when associated with Q-84 and Q-109."; /evidence="ECO:0000269|PubMed:39126279
uniprot
proteins
post_translational_modification
PTM: N-glycosylation of DUOXA1 is required for sorting of DUOX1 to the apical cell membrane. {ECO:0000269|PubMed:39126279}.
uniprot
proteins
protein_family
DUOXA family
uniprot
proteins
pubmed
14670962
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16651268
uniprot
proteins
pubmed
33420071
uniprot
proteins
pubmed
39126279
uniprot
proteins
sequence_length
343
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:39126279}; Multi-pass membrane protein {ECO:0000269|PubMed:33420071}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..43; /note="Helical"; /evidence="ECO:0000269|PubMed:33420071, ECO:0007744|PDB:7D3F"; TRANSMEM 50..72; /note="Helical"; /evidence="ECO:0000269|PubMed:33420071, ECO:0007744|PDB:7D3F"; TRANSMEM 175..199; /note="Helical"; /evidence="ECO:0000269|PubMed:33420071, ECO:0007744|PDB:7D3F"; TRANSMEM 204..227; /note="Helical"; /evidence="ECO:0000269|PubMed:33420071, ECO:0007744|PDB:7D3F"; TRANSMEM 249..270; /note="Helical"; /evidence="ECO:0000269|PubMed:33420071, ECO:0007744|PDB:7D3F
uniprot
proteins