Marchf2
entrez
362849
canonical
uniprot
Q5I0I2
canonical
ensembl
ENSRNOG00000007769
resolver
ensp
ENSRNOP00000010399
resolver
genesymbol
Marchf2
resolver
genesymbol_syn
March2
resolver
genesymbol_syn
Rnf172
resolver
uniprot_entry
MARH2_RAT
resolver
amino_acid_sequence
MTTGDCCHLPGSLCDCSSSPAFSKVVEATGLGPPQYVAQVTSRDGRLLSTVIRALDTPSDCPFCRICHEGANGENLLSPCGCTGTLGAVHKSCLEKWLSSSNTSYCELCHTEFAVEKRPRPLTEWLKDPGPRTEKRTLCCDMVCFVFITPLAAISGWLCLRGAQDHLRLHSRLEAVGLIALTIALFTIYVLWTLVSFRYHCQLYSEWRKTNQKVRLKIREADGSEDPHHSLLATGLLKKVAEETPV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR (By similarity). Ubiquitinates and therefore mediates the degradation of DLG1 (By similarity). Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 (By similarity). Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteasomal degradation (By similarity). May be involved in endosomal trafficking through interaction with STX6. {ECO:0000250|UniProtKB:Q9P0N8, ECO:0000269|PubMed:15689499}.
uniprot
proteins
mass_dalton
27169
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9P0N8}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15689499
uniprot
proteins
pubmed
16428329
uniprot
proteins
sequence_length
246
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15689499}; Multi-pass membrane protein {ECO:0000269|PubMed:15689499}. Lysosome membrane {ECO:0000250|UniProtKB:Q9P0N8}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:15689499}; Multi-pass membrane protein {ECO:0000269|PubMed:15689499}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9P0N8}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9P0N8}. Cell membrane {ECO:0000250|UniProtKB:Q9P0N8}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 138..158; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 175..195; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins