SPINK1
entrez
6690
canonical
uniprot
P00995
canonical
ensembl
ENSG00000164266
resolver
ensp
ENSP00000296695
resolver
enst
ENST00000296695
resolver
genesymbol
SPINK1
resolver
genesymbol_syn
PSTI
resolver
hgnc
HGNC:11244
resolver
uniprot_entry
ISK1_HUMAN
resolver
amino_acid_sequence
MKVTGIFLLSALALLSLSGNTGADSLGREAKCYNELNGCTKIYDPVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC
uniprot
proteins
disease_involvement
DISEASE: Pancreatitis, hereditary (PCTT) [MIM:167800]: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. {ECO:0000269|PubMed:10691414, ECO:0000269|PubMed:10835640, ECO:0000269|PubMed:12974284, ECO:0000269|PubMed:18617776, ECO:0000269|PubMed:19888199}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Tropical calcific pancreatitis (TCP) [MIM:608189]: Idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer. {ECO:0000269|PubMed:12011155, ECO:0000269|PubMed:12187509}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:7142173). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity). {ECO:0000250|UniProtKB:P09036, ECO:0000269|PubMed:7142173}.; FUNCTION: In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production. {ECO:0000250|UniProtKB:P09036}.
uniprot
proteins
mass_dalton
8507
uniprot
proteins
pubmed
10691414
uniprot
proteins
pubmed
10835640
uniprot
proteins
pubmed
12011155
uniprot
proteins
pubmed
12187509
uniprot
proteins
pubmed
12974284
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1613792
uniprot
proteins
pubmed
18617776
uniprot
proteins
pubmed
19888199
uniprot
proteins
pubmed
2961612
uniprot
proteins
pubmed
3501289
uniprot
proteins
pubmed
3877508
uniprot
proteins
pubmed
7142173
uniprot
proteins
pubmed
843082
uniprot
proteins
pubmed
8433367
uniprot
proteins
sequence_length
79
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7142173}.
uniprot
proteins