Ntmt1
entrez
362103
canonical
uniprot
Q5BJX0
canonical
ensembl
ENSRNOG00000024809
resolver
ensembl
ENSRNOG00055007199
resolver
ensembl
ENSRNOG00060032213
resolver
ensembl
ENSRNOG00065021048
resolver
ensp
ENSRNOP00000035921
resolver
ensp
ENSRNOP00000085096
resolver
ensp
ENSRNOP00055009447
resolver
ensp
ENSRNOP00060046185
resolver
ensp
ENSRNOP00065028840
resolver
enst
ENSRNOT00000111041
resolver
enst
ENSRNOT00055011942
resolver
enst
ENSRNOT00060055830
resolver
enst
ENSRNOT00065035779
resolver
genesymbol
Ntmt1
resolver
genesymbol_syn
Mettl11a
resolver
uniprot
A0A8I5ZZE9
resolver
uniprot_entry
A0A8I5ZZE9_RAT
resolver
uniprot_entry
NTM1A_RAT
resolver
amino_acid_sequence
MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISNIDLNSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFRVVDMVDVTEDFLAKAKTYLGEEGKRVRNYFCCGLQDFSPEPSSYDVIWIQWVIGHLTDQHLAEFLRRCRRGLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLEVVRRIIRSAGLSLLAEERQENLPDEIYHVYSFALR
uniprot
proteins
ec_number
2.1.1.244
uniprot
proteins
function
FUNCTION: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. {ECO:0000250|UniProtKB:Q9BV86}.
uniprot
proteins
mass_dalton
25464
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
protein_family
NTM1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BV86}. Note=Predominantly nuclear. {ECO:0000250|UniProtKB:Q9BV86}.
uniprot
proteins