Acod1
entrez
16365
canonical
uniprot
P54987
canonical
ensembl
ENSMUSG00000022126
resolver
ensp
ENSMUSP00000022722
resolver
enst
ENSMUST00000022722
resolver
genesymbol
Acod1
resolver
genesymbol_syn
Irg1
resolver
uniprot
A0A0R4J027
resolver
uniprot
Q3TAA1
resolver
uniprot
Q3U8E8
resolver
uniprot
Q8CBA6
resolver
uniprot_entry
A0A0R4J027_MOUSE
resolver
uniprot_entry
IRG1_MOUSE
resolver
uniprot_sec
Q3TAA1
resolver
uniprot_sec
Q3U8E8
resolver
uniprot_sec
Q8CBA6
resolver
amino_acid_sequence
MMLKSVTESFAGMIHGLKVNHLTDGIIRRSKRMILDSLGVGFLGTGTEVFHKVTQYSKIYSSNTSSTVWGRPDFRLPPTYAAFVNGVAVHSMDFDDTWHPATHPSGAVLPVLTALSEALPQIPKFSGLDLLLAFNVGIEVQGRLMHFSKEAKDIPKRFHPPSVVGTLGSAAAASKFLGLSLTKCREALAIAVSHAGAPIANAATQTKPLHIGNAAKHGMEATFLAMLGLQGNKQILDLGSGFGAFYANYSPEDLPSLDSHIWLLDQQDVAFKSFPAHLATHWVADAAAAVRKHLVTPERALFPADHIERIVLRIPDVQYVNRPFPDSEHEARHSFQYVACASLLDGSITVPSFHSQQVNRPQVRELLKKVKLEHPPDNPPSFDTLYCEISITLKDGTTFTERSDTFYGHWRKPLSQEDLRNKFRANASKMLCRDTVESLITVVEKLEDLEDCSVLTRLLKGPSVQDEASKLSSMSSFDHTTLPRFTNI
uniprot
proteins
ec_number
4.1.1.6
uniprot
proteins
function
FUNCTION: Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response (PubMed:23609450, PubMed:23610393, PubMed:30635240, PubMed:31548418). Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages (PubMed:23609450). Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB (PubMed:23610393, PubMed:35662396). Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (PubMed:30635240). Plays a role in the embryo implantation (PubMed:14500577). {ECO:0000269|PubMed:14500577, ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393, ECO:0000269|PubMed:30635240, ECO:0000269|PubMed:31548418, ECO:0000269|PubMed:35662396}.
uniprot
proteins
mass_dalton
53758
uniprot
proteins
protein_family
PrpD family
uniprot
proteins
pubmed
14500577
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19014335
uniprot
proteins
pubmed
23609450
uniprot
proteins
pubmed
23610393
uniprot
proteins
pubmed
30635240
uniprot
proteins
pubmed
31548418
uniprot
proteins
pubmed
33259501
uniprot
proteins
pubmed
35662396
uniprot
proteins
pubmed
7721348
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:19014335}.
uniprot
proteins