CDHR2
entrez
54825
canonical
uniprot
Q9BYE9
canonical
ensembl
ENSG00000074276
resolver
ensp
ENSP00000261944
resolver
ensp
ENSP00000424565
resolver
ensp
ENSP00000558651
resolver
ensp
ENSP00000558652
resolver
ensp
ENSP00000558653
resolver
ensp
ENSP00000558654
resolver
enst
ENST00000261944
resolver
enst
ENST00000510636
resolver
enst
ENST00000888592
resolver
enst
ENST00000888593
resolver
enst
ENST00000888594
resolver
enst
ENST00000888595
resolver
genesymbol
CDHR2
resolver
genesymbol_syn
PCDH24
resolver
genesymbol_syn
PCLKC
resolver
hgnc
HGNC:18231
resolver
uniprot
A1L3U4
resolver
uniprot
A6NC80
resolver
uniprot
Q9NXP8
resolver
uniprot_entry
CDHR2_HUMAN
resolver
uniprot_sec
A1L3U4
resolver
uniprot_sec
A6NC80
resolver
uniprot_sec
Q9NXP8
resolver
amino_acid_sequence
MAQLWLSCFLLPALVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAVGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQSYRSRLQFSTPKEEVGANRQAINAALTQATRTTVYIVDIQDIDSAARARPHSYLDAYFVFPNGSALTLDELSVMIRNDQDSLTQLLQLGLVVLGSQESQESDLSKQLISVIIGLGVALLLVLVIMTMAFVCVRKSYNRKLQAMKAAKEARKTAAGVMPSAPAIPGTNMYNTERANPMLNLPNKDLGLEYLSPSNDLDSVSVNSLDDNSVDVDKNSQEIKEHRPPHTPPEPDPEPLSVVLLGRQAGASGQLEGPSYTNAGLDTTDL
uniprot
proteins
function
FUNCTION: Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409). May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771). {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409}.
uniprot
proteins
mass_dalton
141543
uniprot
proteins
mutagenesis
MUTAGEN 1310; /note="L->R: Loss of interaction with USH1C."; /evidence="ECO:0000269|PubMed:24725409
uniprot
proteins
pubmed
12117771
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15534908
uniprot
proteins
pubmed
18987736
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24725409
uniprot
proteins
pubmed
26812017
uniprot
proteins
pubmed
26812018
uniprot
proteins
pubmed
32209652
uniprot
proteins
sequence_length
1310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409}; Single-pass type I membrane protein {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409}. Cell projection, microvillus membrane {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:32209652}; Single-pass type I membrane protein {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409}. Cell junction {ECO:0000269|PubMed:12117771}.
uniprot
proteins
transmembrane_region
TRANSMEM 1155..1175; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins