Orc2
entrez
301430
canonical
uniprot
Q75PQ8
canonical
ensembl
ENSRNOG00000012558
resolver
ensembl
ENSRNOG00055023080
resolver
ensembl
ENSRNOG00060026713
resolver
ensembl
ENSRNOG00065029703
resolver
ensp
ENSRNOP00000042867
resolver
ensp
ENSRNOP00000101716
resolver
ensp
ENSRNOP00055032216
resolver
ensp
ENSRNOP00060038558
resolver
ensp
ENSRNOP00065042278
resolver
enst
ENSRNOT00000051843
resolver
enst
ENSRNOT00000128050
resolver
enst
ENSRNOT00055039679
resolver
enst
ENSRNOT00060046397
resolver
enst
ENSRNOT00065051341
resolver
genesymbol
Orc2
resolver
genesymbol_syn
Orc2l
resolver
uniprot
A0ABK0LKC3
resolver
uniprot_entry
A0ABK0LKC3_RAT
resolver
uniprot_entry
ORC2_RAT
resolver
amino_acid_sequence
MSTLRLKEAKVPSVQFVGDDDVLSHILDREGGTKLKKEKVQLLVNPQKVIKKAECELEKSDLEVLEDQNYVEVLGRNIQESLGNGSAVDGRNKVYSFQHRKHPEEMTKLALELAKTSGKIDPLASNDPKITKNIARKSKGHSSEKAPLENNNKNEFPSIQPHNVRKRLIASRSHCDSESEYSASSSEDDEEVAKDDEEDTNVVRCSKKSQGQNRLLPAPVSKEILPKKRKRDKAGDLVEEYFEAHSSSKVLTSDRTLQKLRRARVDQKTLRNLLSKFVPSFSTEIGQLNQQHERLFDKWILQLRLGFNIVLYGLGSKRDLLEKFRTTMLQDSIHVVINGFFPGISVKSILNSITEDVLSHMGTFQSVLDQRDWIMNRFKEDSSLELFLLIHNLDSQMLRGDNSQQILGQLSSLRNVYLIASIDHLNAPLMWDHAKQSLYNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLIHVLRSLTPNARGIFRLLMKYQLDNQDCPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDSGTLADFLEKEEEEES
uniprot
proteins
function
FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
65850
uniprot
proteins
protein_family
ORC2 family
uniprot
proteins
sequence_length
576
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins