Klhl41
entrez
117537
canonical
uniprot
Q9ER30
canonical
ensembl
ENSRNOG00055023842
resolver
ensembl
ENSRNOG00060002973
resolver
ensembl
ENSRNOG00065016420
resolver
ensp
ENSRNOP00055033254
resolver
ensp
ENSRNOP00060003509
resolver
ensp
ENSRNOP00065021457
resolver
enst
ENSRNOT00055040921
resolver
enst
ENSRNOT00060004848
resolver
enst
ENSRNOT00065027326
resolver
genesymbol
Klhl41
resolver
genesymbol_syn
Kbtbd10
resolver
genesymbol_syn
Krp1
resolver
uniprot_entry
KLH41_RAT
resolver
amino_acid_sequence
MDSQRELAEELRLYQSTLLQDGLKDLLEEKKFIDCTLKAGDKSFPCHRLILSACSPYFREYFLSEIEEEKKKEMALDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALSSRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEVVFEAVMKWVRTDKENRAKNLSEVFDCIRFRLMAEKYFKDHVEKDDIIKSNPEVQKKIKVLKDAFAGKLPEPSKSAEKGGTGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPMENECYLTALAEQIPRNHSSIVTQQNQVYVVGGLYVDEENKDQPLQSYFFQLDNVSSEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWSEVKNLPIKVYGHNVISHNGMIYCLGGKTDDKKCTNRVFIYNPKKGDWKDLAPMKTPRSMFGVAIHKGKIVIAGGVTEDGLSASVEAFDLKTNKWEVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNLFKLSKL
uniprot
proteins
function
FUNCTION: Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. {ECO:0000250|UniProtKB:A2AUC9, ECO:0000269|PubMed:10713668}.
uniprot
proteins
mass_dalton
68213
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination. {ECO:0000250|UniProtKB:O60662}.
uniprot
proteins
pubmed
10713668
uniprot
proteins
pubmed
12692149
uniprot
proteins
pubmed
19726686
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
606
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10713668}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10713668}. Cell projection, pseudopodium {ECO:0000269|PubMed:10713668}. Cell projection, ruffle {ECO:0000269|PubMed:10713668}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:A2AUC9}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:O60662}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O60662}. Note=Predominantly cytoplasmic but can colocalize with F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia.
uniprot
proteins