Isy1
entrez
362394
canonical
uniprot
Q6AYB3
canonical
ensembl
ENSRNOG00000037768
resolver
ensembl
ENSRNOG00055012975
resolver
ensembl
ENSRNOG00060024260
resolver
ensembl
ENSRNOG00065015091
resolver
ensp
ENSRNOP00000013571
resolver
ensp
ENSRNOP00055018056
resolver
ensp
ENSRNOP00060034851
resolver
ensp
ENSRNOP00065019554
resolver
enst
ENSRNOT00055022227
resolver
enst
ENSRNOT00060042025
resolver
enst
ENSRNOT00065024984
resolver
genesymbol
Isy1
resolver
uniprot_entry
ISY1_RAT
resolver
amino_acid_sequence
MARNAEKAMTALARFRQAQLEEGKVKERRPFLASECTELPKAEKWRRQIIGEISKKVAQIQNAGLGEFRIRDLNDEINKLLREKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGYKYFGAAKDLPGVRELFEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKRLRAELVEKWKAEREARLARGEKEEEEEEEEINIYAVTEEESDEEGSQEKAGEDGQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEAKRLLGY
uniprot
proteins
function
FUNCTION: Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state (By similarity). Involved in pre-mRNA splicing as component of the spliceosome. {ECO:0000250|UniProtKB:Q69ZQ2, ECO:0000250|UniProtKB:Q9ULR0}.
uniprot
proteins
mass_dalton
32861
uniprot
proteins
protein_family
ISY1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9ULR0}.
uniprot
proteins