Kat2a
entrez
14534
canonical
uniprot
Q9JHD2
canonical
ensembl
ENSMUSG00000020918
resolver
ensp
ENSMUSP00000006973
resolver
ensp
ENSMUSP00000099407
resolver
enst
ENSMUST00000006973
resolver
enst
ENSMUST00000103118
resolver
genesymbol
Kat2a
resolver
genesymbol_syn
Gcn5l2
resolver
uniprot
F8WIY4
resolver
uniprot
Q3TZ59
resolver
uniprot
Q6P3Z8
resolver
uniprot_entry
F8WIY4_MOUSE
resolver
uniprot_entry
KAT2A_MOUSE
resolver
uniprot_entry
Q6P3Z8_MOUSE
resolver
uniprot_sec
Q3TZ59
resolver
amino_acid_sequence
MAEPSQAPNPVPAAQPRPLHSPAPAPTSTPAPSPASASTPAPTPAPAPAPAAAPAGSTGSGGAGVGSGGDPARPGLSQQQRASQRKAQVRGLPRAKKLEKLGVFSACKANETCKCNGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSHLENVSEDEINRLLGMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQGVLNFVQYKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQSEDVATYKVNYTRWLCYCHVPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFLSMLEEEIYGANSPIWESGFTMPPSEGTQLVPRPATVSATVVPSFSPSMGGGSNSSLSLDSAGTEPMPAGEKRKLPENLTLEDAKRLRVMGDIPMELVNEVMLTITDPAAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHSILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLGKEKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.48
uniprot
proteins
function
FUNCTION: Protein lysine acyltransferase that catalyzes acetylation of histone and non-histone proteins using acetyl-CoA (PubMed:28424240). Also catalyzes acyl-CoA-dependent acylation of lysine residues in proteins using alternative acyl-CoA donors, including propionyl-CoA, butyryl-CoA, succinyl-CoA, glutaryl-CoA, crotonyl-CoA and lactoyl-CoA (By similarity). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (By similarity). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (By similarity). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (By similarity). Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac) (By similarity). Also catalyzes acetylation of histone H1.4 (H1-4) at 'Lys-34' (H1.4K34ac), a modification enriched at promoters of active genes (By similarity). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:28424240). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (By similarity). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (PubMed:25024434). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (PubMed:28424240). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (PubMed:30424580). Regulates embryonic stem cell (ESC) pluripotency and differentiation (PubMed:30270482). Also acetylates non-histone proteins, such as CEBPB, CGAS, MRE11, PPARGC1A, PLK4 and TBX5 (PubMed:17301242). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (By similarity). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (By similarity). Acts as a negative regulator of gluconeogenesis by mediating acetylation and subsequent inactivation of PPARGC1A (By similarity). Acts as a positive regulator of cGAS-STING signaling by mediating acetylation and activation of CGAS (By similarity). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (By similarity). Catalyzes histone H3 lactylation at 'Lys-14' and 'Lys-18' in a lactyl-CoA-dependent manner (By similarity). Lactyl-CoA for this reaction can be generated by ACSS2 (By similarity). {ECO:0000250|UniProtKB:Q92830, ECO:0000269|PubMed:17301242, ECO:0000269|PubMed:25024434, ECO:0000269|PubMed:28424240, ECO:0000269|PubMed:30270482, ECO:0000269|PubMed:30424580}.
uniprot
proteins
mass_dalton
93394
uniprot
proteins
post_translational_modification
PTM: Acetylated at Lys-542, inhibiting the protein acetyltransferase activity (By similarity). Deacetylation at Lys-542 by SIRT6 promotes phosphorylation at Ser-302 and Thr-728 and subsequent activation of the protein acetyltransferase activity, leading to acetylation and inactivation of PPARGC1A (By similarity). {ECO:0000250|UniProtKB:Q92830}.
uniprot
proteins
protein_family
Acetyltransferase family
uniprot
proteins
protein_family
GCN5 subfamily
uniprot
proteins
pubmed
11017084
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17301242
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22886304
uniprot
proteins
pubmed
25024434
uniprot
proteins
pubmed
28424240
uniprot
proteins
pubmed
30270482
uniprot
proteins
pubmed
30424580
uniprot
proteins
pubmed
36112854
uniprot
proteins
pubmed
9742083
uniprot
proteins
sequence_length
830
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92830}. Chromosome {ECO:0000269|PubMed:28424240}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q92830}. Note=Mainly localizes to the nucleus. Localizes to sites of DNA damage. Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation. {ECO:0000250|UniProtKB:Q92830}.
uniprot
proteins