CDC37
entrez
11140
canonical
uniprot
Q16543
canonical
ensembl
ENSG00000105401
resolver
ensp
ENSP00000222005
resolver
enst
ENST00000222005
resolver
genesymbol
CDC37
resolver
genesymbol_syn
CDC37A
resolver
hgnc
HGNC:1735
resolver
uniprot
Q53YA2
resolver
uniprot_entry
CDC37_HUMAN
resolver
uniprot_sec
Q53YA2
resolver
amino_acid_sequence
MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV
uniprot
proteins
function
FUNCTION: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}.
uniprot
proteins
mass_dalton
44468
uniprot
proteins
post_translational_modification
PTM: Constitutively sumoylated by UBE2I. {ECO:0000269|PubMed:17709345}.
uniprot
proteins
protein_family
CDC37 family
uniprot
proteins
pubmed
10409742
uniprot
proteins
pubmed
10858314
uniprot
proteins
pubmed
11036079
uniprot
proteins
pubmed
11085988
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
17709345
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23569206
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27353360
uniprot
proteins
pubmed
29127155
uniprot
proteins
pubmed
8666233
uniprot
proteins
pubmed
8703009
uniprot
proteins
pubmed
9150368
uniprot
proteins
pubmed
9482106
uniprot
proteins
sequence_length
378
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9482106}.
uniprot
proteins