Serpina10
entrez
217847
canonical
uniprot
Q8R121
canonical
ensembl
ENSMUSG00000061947
resolver
ensp
ENSMUSP00000048357
resolver
ensp
ENSMUSP00000113644
resolver
genesymbol
Serpina10
resolver
genesymbol_syn
Zpi
resolver
uniprot
Q8VCV8
resolver
uniprot_entry
ZPI_MOUSE
resolver
uniprot_sec
Q8VCV8
resolver
amino_acid_sequence
MRVASSLFLPVLLTEVWLVTSFNLSSHSPEASVHLESQDYENQTWEEYTRTDPREEEEEEEEKEEGKDEEYWLRASQQLSNETSSFGFNLLRKISMRHDGNVIFSPFGLSVAMVNLMLGTKGETKVQIENGLNLQALSQAGPLILPALFKKVKETFSSNRDLGLSQGSFAFIHKDFDIKETYFNLSKKYFDIEYVSINFQNSSQARGLINHCIVKETEGKIPKLFDEINPETKLILVDYVLFKGKWLTPFDPSFTEADTFHLDKYRAIKVPMMYREGNFTSTFDKKFRCHILKLPYQGNATMLVVLMEKTGDYLALEDYLTVDLVETWLQNMKTRKMEVFFPKFKLNQRYEMHELLKQMGIRRLFSTSADLSELSAMARNLQVSRVLQQSVLEVDERGTEAVSGTLSEIIAYSMPPAIKVNRPFHFIIYEEMSRMLLFLGRVVNPTVL
uniprot
proteins
function
FUNCTION: Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
51797
uniprot
proteins
mutagenesis
MUTAGEN 96; /note="M->A: 2-fold decrease in rates of factor Xa inhibition."; /evidence="ECO:0000269|PubMed:22786881"; MUTAGEN 99; /note="D->A: 5-fold decrease in rates of factor Xa inhibition."; /evidence="ECO:0000269|PubMed:22786881"; MUTAGEN 263; /note="D->A: No change in rates of factor Xa inhibition."; /evidence="ECO:0000269|PubMed:22786881"; MUTAGEN 264; /note="K->A: No change in rates of factor Xa inhibition."; /evidence="ECO:0000269|PubMed:22786881"; MUTAGEN 265; /note="Y->A: 50-fold decrease in rates of factor Xa inhibition."; /evidence="ECO:0000269|PubMed:22786881"; MUTAGEN 318; /note="D->A: 400-fold decrease in rates of factor Xa inhibition."; /evidence="ECO:0000269|PubMed:22786881
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FAM20C in the extracellular medium. {ECO:0000250|UniProtKB:Q9UK55}.
uniprot
proteins
protein_family
Serpin family
uniprot
proteins
pubmed
11372680
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16944957
uniprot
proteins
pubmed
17330941
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22786881
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins