HLA-DQA2
entrez
3118
canonical
uniprot
P01906
canonical
ensembl
ENSG00000206301
resolver
ensembl
ENSG00000223793
resolver
ensembl
ENSG00000225103
resolver
ensembl
ENSG00000231526
resolver
ensembl
ENSG00000231823
resolver
ensembl
ENSG00000233192
resolver
ensembl
ENSG00000237541
resolver
ensembl
ENSG00000257473
resolver
ensp
ENSP00000241802
resolver
ensp
ENSP00000364076
resolver
ensp
ENSP00000387768
resolver
ensp
ENSP00000390725
resolver
ensp
ENSP00000393431
resolver
ensp
ENSP00000400695
resolver
ensp
ENSP00000401098
resolver
ensp
ENSP00000405833
resolver
ensp
ENSP00000447668
resolver
ensp
ENSP00000448003
resolver
enst
ENST00000241802
resolver
enst
ENST00000374940
resolver
enst
ENST00000415898
resolver
enst
ENST00000443184
resolver
enst
ENST00000446482
resolver
enst
ENST00000447735
resolver
enst
ENST00000449560
resolver
enst
ENST00000453672
resolver
enst
ENST00000546801
resolver
enst
ENST00000551533
resolver
genesymbol
HLA-DQA2
resolver
genesymbol_syn
HLA-DXA
resolver
hgnc
HGNC:4943
resolver
uniprot
A2BF37
resolver
uniprot
B0V0E7
resolver
uniprot
O19789
resolver
uniprot
Q5SQ94
resolver
uniprot
Q5SR04
resolver
uniprot_entry
DQA2_HUMAN
resolver
uniprot_sec
A2BF37
resolver
uniprot_sec
B0V0E7
resolver
uniprot_sec
O19789
resolver
uniprot_sec
Q5SQ94
resolver
uniprot_sec
Q5SR04
resolver
amino_acid_sequence
MILNKALLLGALALTAVMSPCGGEDIVADHVASYGVNFYQSHGPSGQYTHEFDGDEEFYVDLETKETVWQLPMFSKFISFDPQSALRNMAVGKHTLEFMMRQSNSTAATNEVPEVTVFSKFPVTLGQPNTLICLVDNIFPPVVNITWLSNGHSVTEGVSETSFLSKSDHSFFKISYLTFLPSADEIYDCKVEHWGLDEPLLKHWEPEIPAPMSELTETLVCALGLSVGLMGIVVGTVFIIQGLRSVGASRHQGLL
uniprot
proteins
function
FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. {ECO:0000269|PubMed:22407913}.
uniprot
proteins
mass_dalton
28033
uniprot
proteins
protein_family
MHC class II family
uniprot
proteins
pubmed
11684289
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
17241953
uniprot
proteins
pubmed
18046453
uniprot
proteins
pubmed
19092054
uniprot
proteins
pubmed
19533806
uniprot
proteins
pubmed
22407913
uniprot
proteins
pubmed
2513578
uniprot
proteins
pubmed
3036828
uniprot
proteins
pubmed
3610256
uniprot
proteins
pubmed
6584734
uniprot
proteins
pubmed
8026991
uniprot
proteins
pubmed
8598037
uniprot
proteins
pubmed
9036956
uniprot
proteins
sequence_length
255
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Lysosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
uniprot
proteins
transmembrane_region
TRANSMEM 218..240; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins