Ccr8
entrez
12776
canonical
uniprot
P56484
canonical
ensembl
ENSMUSG00000042262
resolver
ensp
ENSMUSP00000038473
resolver
enst
ENSMUST00000048777
resolver
genesymbol
Ccr8
resolver
genesymbol_syn
Cmkbr8
resolver
genesymbol_syn
Ter1
resolver
uniprot
Q3ZB17
resolver
uniprot_entry
CCR8_MOUSE
resolver
uniprot_entry
Q3ZB17_MOUSE
resolver
amino_acid_sequence
MDYTMEPNVTMTDYYPDFFTAPCDAEFLLRGSMLYLAILYCVLFVLGLLGNSLVILVLVGCKKLRSITDIYLLNLAASDLLFVLSIPFQTHNLLDQWVFGTAMCKVVSGLYYIGFFSSMFFITLMSVDRYLAIVHAVYAIKVRTASVGTALSLTVWLAAVTATIPLMVFYQVASEDGMLQCFQFYEEQSLRWKLFTHFEINALGLLLPFAILLFCYVRILQQLRGCLNHNRTRAIKLVLTVVIVSLLFWVPFNVALFLTSLHDLHILDGCATRQRLALAIHVTEVISFTHCCVNPVIYAFIGEKFKKHLMDVFQKSCSHIFLYLGRQMPVGALERQLSSNQRSSHSSTLDDIL
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18 (PubMed:9469461). Regulates monocyte and eosinophil chemotaxis (PubMed:11238588). Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways (By similarity). Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage by supporting lymphoid cells IFN-gamma production (PubMed:33613532). {ECO:0000250|UniProtKB:P51685, ECO:0000269|PubMed:11238588, ECO:0000269|PubMed:33613532, ECO:0000269|PubMed:9469461}.
uniprot
proteins
mass_dalton
40045
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11238588
uniprot
proteins
pubmed
33613532
uniprot
proteins
pubmed
9469461
uniprot
proteins
pubmed
9670926
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P51685}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51685}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..61; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 72..91; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 106..127; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 145..169; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 201..220; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 237..261; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 279..302; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins