SLC22A24
entrez
283238
canonical
uniprot
Q8N4F4
canonical
ensembl
ENSG00000197658
resolver
ensp
ENSP00000321549
resolver
ensp
ENSP00000480336
resolver
genesymbol
SLC22A24
resolver
hgnc
HGNC:28542
resolver
uniprot
A0A087WWM3
resolver
uniprot
C9JC66
resolver
uniprot_entry
S22AO_HUMAN
resolver
uniprot_sec
A0A087WWM3
resolver
uniprot_sec
C9JC66
resolver
activity_regulation
ACTIVITY REGULATION: Transport is chloride sensitive and transtimulated by glutaric acid (PubMed:31553721). Transport is inhibited by anionic compounds from different chemical classes (PubMed:31553721). {ECO:0000269|PubMed:31553721}.
uniprot
proteins
amino_acid_sequence
MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENDRKDSRNIKQEDTCMKVTQF
uniprot
proteins
function
FUNCTION: Renal transmembrane organic anion/dicarboxylate exchanger that participates in the reabsorption of conjugated steroids including estradiol-17beta-D-glucuronide (or 17beta-estradiol 17-O-(beta-D-glucuronate)), androstanediol glucuronide (or 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)), and estrone 3-sulfate, as well as bile acids taurocholate and glycocholate, driven by an outward gradient of dicarboxylates such as glutarate or succinate. {ECO:0000269|PubMed:31553721, ECO:0000305|PubMed:17714910}.; FUNCTION: [Isoform 2]: Similar uptake function as Isoform 1. {ECO:0000269|PubMed:31553721}.; FUNCTION: [Isoform 3]: Lack of transporter activity. {ECO:0000269|PubMed:31553721}.
uniprot
proteins
mass_dalton
61701
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17714910
uniprot
proteins
pubmed
31553721
uniprot
proteins
sequence_length
552
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:31553721}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:31553721}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 178..200; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 204..226; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 234..254; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 350..370; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 380..400; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 435..455; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 474..492; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 496..516; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins