Mx1
entrez
17857
canonical
uniprot
P09922
canonical
ensembl
ENSMUSG00000000386
resolver
genesymbol
Mx1
resolver
genesymbol_syn
Mx
resolver
uniprot
Q4FJJ9
resolver
uniprot_entry
MX1B_MOUSE
resolver
uniprot_entry
Q4FJJ9_MOUSE
resolver
amino_acid_sequence
MDSVNNLCRHYEEKVRPCIDLIDTLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLRKLKEGEEWRGKVSYDDIEVELSDPSEVEEAINKGQNFIAGVGLGISDKLISLDVSSPNVPDLTLIDLPGITRVAVGNQPADIGRQIKRLIKTYIQKQETINLVVVPSNVDIATTEALSMAQEVDPEGDRTIGVLTKPDLVDRGAEGKVLDVMRNLVYPLKKGYMIVKCRGQQDIQEQLSLTEAFQKEQVFFKDHSYFSILLEDGKATVPCLAERLTEELTSHICKSLPLLEDQINSSHQSASEELQKYGADIPEDDRTRMSFLVNKISAFNRNIMNLIQAQETVSEGDSRLFTKLRNEFLAWDDHIEEYFKKDSPEVQSKMKEFENQYRGRELPGFVDYKAFESIIKKRVKALEESAVNMLRRVTKMVQTAFVKILSNDFGDFLNLCCTAKSKIKEIRLNQEKEAENLIRLHFQMEQIVYCQDQVYKETLKTIREKEAEKEKTKALINPATFQNNSQFPQKGLTTTEMTQHLKAYYQECRRNIGRQIPLIIQYFILKTFGEEIEKMMLQLLQDTSKCSWFLEEQSDTREKKKFLKRRLLRLDEARQKLAKFSD
uniprot
proteins
function
FUNCTION: Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV), influenza B virus (IBV) and Thogoto virus (THOV). Inhibits FLUAV by interfering with the process of primary transcription, probably by affecting the viral polymerase function. {ECO:0000269|PubMed:17652381, ECO:0000269|PubMed:21651940}.
uniprot
proteins
mass_dalton
72038
uniprot
proteins
mutagenesis
MUTAGEN 47; /note="S->C: No effect on viral infection."; /evidence="ECO:0000269|PubMed:8411374"; MUTAGEN 49; /note="K->A,M: Loss of protection against viral infection."; /evidence="ECO:0000269|PubMed:8411374
uniprot
proteins
post_translational_modification
PTM: ISGylated. {ECO:0000250}.
uniprot
proteins
protein_family
Dynamin/Fzo/YdjA family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17652381
uniprot
proteins
pubmed
18062906
uniprot
proteins
pubmed
21651940
uniprot
proteins
pubmed
21859714
uniprot
proteins
pubmed
22190720
uniprot
proteins
pubmed
2903437
uniprot
proteins
pubmed
2974922
uniprot
proteins
pubmed
3000619
uniprot
proteins
pubmed
8411374
uniprot
proteins
sequence_length
631
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21859714}. Nucleus {ECO:0000269|PubMed:21859714}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P20591}; Peripheral membrane protein {ECO:0000250|UniProtKB:P20591}; Cytoplasmic side {ECO:0000250|UniProtKB:P20591}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P20591}. Note=Binds preferentially to negatively charged phospholipids. Colocalizes with CCHFV protein N in the perinuclear region. {ECO:0000250|UniProtKB:P20591}.
uniprot
proteins