Ly9
entrez
17085
canonical
uniprot
Q01965
canonical
ensembl
ENSMUSG00000004707
resolver
ensp
ENSMUSP00000004827
resolver
ensp
ENSMUSP00000069319
resolver
enst
ENSMUST00000004827
resolver
enst
ENSMUST00000068878
resolver
genesymbol
Ly9
resolver
genesymbol_syn
Ly-9
resolver
uniprot
E9PX73
resolver
uniprot
Q9ES29
resolver
uniprot
Q9ES35
resolver
uniprot
Q9ES36
resolver
uniprot_entry
E9PX73_MOUSE
resolver
uniprot_entry
LY9_MOUSE
resolver
uniprot_sec
Q9ES29
resolver
uniprot_sec
Q9ES35
resolver
uniprot_sec
Q9ES36
resolver
amino_acid_sequence
MADLKRYWCDWALGPLSENPRMSQQQIFSPILWIPLLFLLMGLGASGKETPPTVISGMLGGSVTFSLNISKDAEIEHIIWNCPPKALALVFYKKDITILDKGYNGRLKVSEDGYSLYMSNLTKSDSGSYHAQINQKNVILTTNKEFTLHIYEKLQKPQIIVESVTPSDTDSCTFTLICTVKGTKDSVQYSWTREDTHLNTYDGSHTLRVSQSVCDPDLPYTCKAWNPVSQNSSQPVRIWQFCTGASRRKTAAGKTVVGILGEPVTLPLEFRATRATKNVVWVFNTSVISQERRGAATADSRRKPKGSEERRVRTSDQDQSLKISQLKMEDAGPYHAYVCSEASRDPSVRHFTLLVYKRLEKPSVTKSPVHMMNGICEVVLTCSVDGGGNNVTYTWMPLQNKAVMSQGKSHLNVSWESGEHLPNFTCTAHNPVSNSSSQFSSGTICSGPERNKRFWLLLLLVLLLLMLIGGYFILRKKKQCSSLATRYRQAEVPAEIPETPTGHGQFSVLSQRYEKLDMSAKTTRHQPTPTSDTSSESSATTEEDDEKTRMHSTANSRNQVYDLVTHQDIAHALAYEGQVEYEAITPYDKVDGSMDEEDMAYIQVSLNVQGETPLPQKKEDSNTIYCSVQKPKKTAQTPQQDAESPETPTYENFT
uniprot
proteins
function
FUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:19648922). May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A. Promotes recruitment of RORC to the IL-17 promoter (By similarity). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells (PubMed:23914190). May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (PubMed:23225888). Can promote natural killer (NK) cell activation (PubMed:19648922). {ECO:0000250|UniProtKB:Q9HBG7, ECO:0000269|PubMed:19648922, ECO:0000269|PubMed:23225888, ECO:0000269|PubMed:23914190}.
uniprot
proteins
mass_dalton
73143
uniprot
proteins
pubmed
10970093
uniprot
proteins
pubmed
1506686
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19648922
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23225888
uniprot
proteins
pubmed
23914190
uniprot
proteins
sequence_length
654
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 454..474; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins