BRMS1
entrez
25855
canonical
uniprot
Q9HCU9
canonical
ensembl
ENSG00000174744
resolver
ensp
ENSP00000353042
resolver
ensp
ENSP00000396052
resolver
ensp
ENSP00000431510
resolver
ensp
ENSP00000591922
resolver
ensp
ENSP00000591925
resolver
ensp
ENSP00000653970
resolver
enst
ENST00000359957
resolver
enst
ENST00000425825
resolver
enst
ENST00000921863
resolver
enst
ENST00000921866
resolver
genesymbol
BRMS1
resolver
hgnc
HGNC:17262
resolver
uniprot
G5E9I4
resolver
uniprot
Q6IAI2
resolver
uniprot_entry
BRMS1_HUMAN
resolver
uniprot_entry
G5E9I4_HUMAN
resolver
uniprot_sec
Q6IAI2
resolver
amino_acid_sequence
MPVQPPSKDTEEMEAEGDSAAEMNGEEEESEEERSGSQTESEEESSEMDDEDYERRRSECVSEMLDLEKQFSELKEKLFRERLSQLRLRLEEVGAERAPEYTEPLGGLQRSLKIRIQVAGIYKGFCLDVIRNKYECELQGAKQHLESEKLLLYDTLQGELQERIQRLEEDRQSLDLSSEWWDDKLHARGSSRSWDSLPPSKRKKAPLVSGPYIVYMLQEIDILEDWTAIKKARAAVSPQKRKSDGP
uniprot
proteins
function
FUNCTION: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. {ECO:0000269|PubMed:14581478, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:20830743}.
uniprot
proteins
mass_dalton
28461
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation. {ECO:0000269|PubMed:22085717}.
uniprot
proteins
protein_family
BRMS1 family
uniprot
proteins
pubmed
10850410
uniprot
proteins
pubmed
12414911
uniprot
proteins
pubmed
14581478
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17000776
uniprot
proteins
pubmed
20830743
uniprot
proteins
pubmed
21777593
uniprot
proteins
pubmed
22085717
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
246
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly nuclear.
uniprot
proteins