C1s1
entrez
50908
canonical
uniprot
Q8CG14
canonical
ensembl
ENSMUSG00000038521
resolver
ensp
ENSMUSP00000125531
resolver
ensp
ENSMUSP00000125712
resolver
enst
ENSMUST00000160505
resolver
enst
ENSMUST00000162443
resolver
genesymbol
C1s1
resolver
genesymbol_syn
C1s
resolver
genesymbol_syn
C1sa
resolver
uniprot
E9Q6C2
resolver
uniprot
Q14DT6
resolver
uniprot
Q8BJC4
resolver
uniprot
Q8CH28
resolver
uniprot
Q8VBY4
resolver
uniprot_entry
CS1A_MOUSE
resolver
uniprot_entry
E9Q6C2_MOUSE
resolver
uniprot_entry
Q14DT6_MOUSE
resolver
uniprot_sec
Q8BJC4
resolver
uniprot_sec
Q8CH28
resolver
uniprot_sec
Q8VBY4
resolver
activity_regulation
ACTIVITY REGULATION: Cleaved and activated by C1R. Immunoglobulin-binding promotes autoactivation of C1R, which results in the cleavage of the Arg-Ile bond in the catalytic domain. Inhibited by C1 inhibitor (SERPING1). {ECO:0000250|UniProtKB:P09871}.
uniprot
proteins
amino_acid_sequence
MWCLVLFSLLASFSAEPTMHGEILSPNYPQAYPNDVVKSWDIEVPEGFGIHLYFTHVDIEPSESCAYDSVQIISGGIEEGRLCGQKTSKSPNSPIIEEFQFPYNKLQVVFTSDFSNEERFTGFAAYYTAIDINECTDFTDVPCSHFCNNFIGGYFCSCPPEYFLHDDMRNCGVNCSGDVFTALIGEISSPNYPNPYPENSRCEYQIQLQEGFQVVVTMQREDFDVEPADSEGNCPDSLTFASKNQQFGPYCGNGFPGPLTIRTQSNTLGIVFQTDLMGQKKGWKLRYHGDPISCAKKITANSTWEPDKAKYVFKDVVKITCVDGFEVVEGHVSSTSYYSTCQSDGQWSNSGLKCQPVYCGIPDPIANGKVEEPENSVFGTVVHYTCEEPYYYMEHEEGGEYRCAANGRWVNDQLGIELPRCIPACGVPTEPFQVHQRIFGGQPAKIENFPWQVFFNHPRASGALINEYWVLTAAHVLEKISDPLMYVGTMSVRTTLLENAQRLYSKRVFIHPSWKKEDDPNTRTNFDNDIALVQLKDPVKMGPKVSPICLPGTSSEYNVSPGDMGLISGWGSTEKKVFVINLRGAKVPVTSLETCKQVKEENPTVRPEDYVFTDNMICAGEKGVDSCHGDSGGAFAFQVPNVTVPKFYVAGLVSWGKRCGTYGVYTKVKNYVDWILKTMQENSGPRKD
uniprot
proteins
ec_number
3.4.21.42
uniprot
proteins
function
FUNCTION: Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens. C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains. C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway. {ECO:0000250|UniProtKB:P09871}.; FUNCTION: [Complement C1s-A subcomponent light chain]: Serine protease component of the complement C1 complex, which catalyzes cleavage and activation of C2 and C4, the next components of the classical complement pathway. Also cleaves IGFBP5 and thereby inhibits the trophic effects of IGF1. {ECO:0000250|UniProtKB:P09871}.
uniprot
proteins
mass_dalton
76858
uniprot
proteins
post_translational_modification
PTM: Cleaved and activated by C1R to generate Complement C1s subcomponent heavy and light chains. {ECO:0000250|UniProtKB:P09871}.; PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. {ECO:0000250|UniProtKB:P09871}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
12513694
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
688
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P09871}. Cell surface {ECO:0000250|UniProtKB:P09871}. Note=Recruited to the surface of pathogens by the C1Q subcomplex. {ECO:0000250|UniProtKB:P09871}.
uniprot
proteins