SGF29
entrez
112869
canonical
uniprot
Q96ES7
canonical
ensembl
ENSG00000176476
resolver
ensp
ENSP00000316114
resolver
ensp
ENSP00000568174
resolver
ensp
ENSP00000568176
resolver
ensp
ENSP00000568178
resolver
ensp
ENSP00000568180
resolver
ensp
ENSP00000600871
resolver
ensp
ENSP00000789816
resolver
enst
ENST00000317058
resolver
enst
ENST00000898115
resolver
enst
ENST00000898117
resolver
enst
ENST00000898119
resolver
enst
ENST00000898121
resolver
enst
ENST00000930812
resolver
genesymbol
SGF29
resolver
genesymbol_syn
CCDC101
resolver
hgnc
HGNC:25156
resolver
uniprot
Q96MF5
resolver
uniprot_entry
SGF29_HUMAN
resolver
uniprot_sec
Q96MF5
resolver
amino_acid_sequence
MALVSADSRIAELLTELHQLIKQTQEERSRSEHNLVNIQKTHERMQTENKISPYYRTKLRGLYTTAKADAEAECNILRKALDKIAEIKSLLEERRIAAKIAGLYNDSEPPRKTMRRGVLMTLLQQSAMTLPLWIGKPGDKPPPLCGAIPASGDYVARPGDKVAARVKAVDGDEQWILAEVVSYSHATNKYEVDDIDEEGKERHTLSRRRVIPLPQWKANPETDPEALFQKEQLVLALYPQTTCFYRALIHAPPQRPQDDYSVLFEDTSYADGYSPPLNVAQRYVVACKEPKKK
uniprot
proteins
function
FUNCTION: Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:21685874, PubMed:26421618, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:21685874, PubMed:26421618, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581). Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-506' (By similarity). {ECO:0000250|UniProtKB:Q9DA08, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:21685874, ECO:0000269|PubMed:23894581, ECO:0000269|PubMed:26421618, ECO:0000269|PubMed:26578293}.
uniprot
proteins
mass_dalton
33238
uniprot
proteins
mutagenesis
MUTAGEN 175; /note="W->A: Does not strongly affect binding to H3K4me."; /evidence="ECO:0000269|PubMed:20850016"; MUTAGEN 179; /note="E->A: Does not strongly affect binding to H3K4me."; /evidence="ECO:0000269|PubMed:20850016"; MUTAGEN 194; /note="D->A,R: Abolishes H3K4me3 binding."; /evidence="ECO:0000269|PubMed:21685874"; MUTAGEN 196; /note="D->R: Abolishes H3K4me3 binding."; /evidence="ECO:0000269|PubMed:21685874"; MUTAGEN 214; /note="P->A: Does not strongly affect binding to H3K4me."; /evidence="ECO:0000269|PubMed:20850016"; MUTAGEN 232; /note="Q->A: Does not strongly affect binding to H3K4me."; /evidence="ECO:0000269|PubMed:20850016"; MUTAGEN 238; /note="Y->A: Strongly reduced H3K4me3 binding."; /evidence="ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:21685874"; MUTAGEN 238; /note="Y->F: Does not affect binding to H3K4me3."; /evidence="ECO:0000269|PubMed:26421618"; MUTAGEN 240; /note="Q->A: Slightly reduced H3K4me3 binding."; /evidence="ECO:0000269|PubMed:21685874"; MUTAGEN 242; /note="T->A: Almost abolished H3K4me3 binding."; /evidence="ECO:0000269|PubMed:21685874"; MUTAGEN 245; /note="Y->A: Abolishes H3K4me3 binding."; /evidence="ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:21685874"; MUTAGEN 245; /note="Y->F: Reduced H3K4me3 binding."; /evidence="ECO:0000269|PubMed:26421618"; MUTAGEN 256; /note="P->A: Does not strongly affect binding to H3K4me."; /evidence="ECO:0000269|PubMed:20850016"; MUTAGEN 264; /note="F->A: Strongly reduced binding to H3K4me3."; /evidence="ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:21685874"; MUTAGEN 266; /note="D->A,F,Y,W: Strongly reduced binding to H3K4me3."; /evidence="ECO:0000269|PubMed:21685874, ECO:0000269|PubMed:26421618"; MUTAGEN 266; /note="D->E: Does not affect binding to H3K4me3."; /evidence="ECO:0000269|PubMed:26421618"; MUTAGEN 266; /note="D->N: Slightly reduced binding to H3K4me3."; /evidence="ECO:0000269|PubMed:26421618"; MUTAGEN 282; /note="R->A: Does not strongly affect binding to H3K4me."; /evidence="ECO:0000269|PubMed:20850016
uniprot
proteins
protein_family
SGF29 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19103755
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20850016
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21685874
uniprot
proteins
pubmed
23894581
uniprot
proteins
pubmed
26421618
uniprot
proteins
pubmed
26578293
uniprot
proteins
sequence_length
293
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P0C606}.
uniprot
proteins