Tnfaip8l2
entrez
310663
canonical
uniprot
Q6AYJ8
canonical
ensembl
ENSRNOG00000021100
resolver
ensembl
ENSRNOG00055030672
resolver
ensembl
ENSRNOG00060012442
resolver
ensembl
ENSRNOG00065028266
resolver
ensp
ENSRNOP00000028642
resolver
ensp
ENSRNOP00000094344
resolver
ensp
ENSRNOP00000103256
resolver
ensp
ENSRNOP00000107205
resolver
ensp
ENSRNOP00000110113
resolver
ensp
ENSRNOP00055043978
resolver
ensp
ENSRNOP00055043983
resolver
ensp
ENSRNOP00060016644
resolver
ensp
ENSRNOP00060016650
resolver
ensp
ENSRNOP00065039920
resolver
ensp
ENSRNOP00065039932
resolver
enst
ENSRNOT00000028642
resolver
enst
ENSRNOT00000116833
resolver
enst
ENSRNOT00000125109
resolver
enst
ENSRNOT00000134844
resolver
enst
ENSRNOT00000140672
resolver
enst
ENSRNOT00055053213
resolver
enst
ENSRNOT00055053218
resolver
enst
ENSRNOT00060021095
resolver
enst
ENSRNOT00060021101
resolver
enst
ENSRNOT00065048684
resolver
enst
ENSRNOT00065048697
resolver
genesymbol
Tnfaip8l2
resolver
uniprot
A0ABK0LZR3
resolver
uniprot_entry
A0ABK0LZR3_RAT
resolver
uniprot_entry
TP8L2_RAT
resolver
amino_acid_sequence
MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRSKAQRVIKDLIKVAVKVAVLHRSGCFSPGELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLLIECREILLELVEHHLTPKSHDRIRHVFDHYSDPDLLTALYGPDFTQHLDKICDGLRKLLDEGKL
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression (By similarity). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Also inhibits autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (By similarity). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (By similarity). {ECO:0000250|UniProtKB:Q6P589, ECO:0000250|UniProtKB:Q9D8Y7}.
uniprot
proteins
mass_dalton
20751
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by TAK1/MAP3K7; this phosphorylation triggers association with BTRC and subsequent ubiquitination and degradation. {ECO:0000250|UniProtKB:Q6P589}.; PTM: Ubiquitinated in a BTRC-depdent manner; leading to degradation mediated through the proteasome pathway. {ECO:0000250|UniProtKB:Q6P589}.
uniprot
proteins
protein_family
TNFAIP8 family
uniprot
proteins
protein_family
TNFAIP8L2 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6P589}. Nucleus {ECO:0000250|UniProtKB:Q6P589}. Lysosome {ECO:0000250|UniProtKB:Q6P589}.
uniprot
proteins