Atp1a4
entrez
27222
canonical
uniprot
Q9WV27
canonical
ensembl
ENSMUSG00000007107
resolver
ensp
ENSMUSP00000106874
resolver
enst
ENSMUST00000111243
resolver
genesymbol
Atp1a4
resolver
genesymbol_syn
Atp1al2
resolver
uniprot
E9QKL5
resolver
uniprot
Q9R173
resolver
uniprot
Q9WV28
resolver
uniprot_entry
AT1A4_MOUSE
resolver
uniprot_sec
E9QKL5
resolver
uniprot_sec
Q9R173
resolver
uniprot_sec
Q9WV28
resolver
activity_regulation
ACTIVITY REGULATION: Specifically inhibited by an endogenous cardiac glycoside, ouabain. {ECO:0000250|UniProtKB:Q13733}.
uniprot
proteins
amino_acid_sequence
MEPGKEKEVEAPGELNQKPRPSTRSSTTNRQPKMKRRKKDLEELKKEVVMDDHKLTLDELSAKYSVDLTKGLSILEAQDILFQNGPNVLTPPPTTPEWVKFCRQLFGGFSLLLWTGACLCFLAYGIHVNYYKENANKDNLYLGIVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRDGEKMQINVRDVVLGDLVEVKGGDQIPADIRVISAQGCKVDNSSLTGESEPQSRCPDCTHENPLETRNIIFFSTNCVEGTARGIVIATGDYTVMGRIASLTSGLQMGKTPIATEIEHFIHLITAVAVFLGVSFFWLSIILGYTWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWFDKTVYEADTSEEQTTGKTFPKSSDTWFYLARIAGLCNRADFKPHQESVPIAKRATTGDASESALLKFIEQSYNPVSEMRQKNPKVAEIPFNSTNKYQMSIHLLEDNSEAHVLLMKGAPERIFDFCSSFLLNGQEYPMDEEMKMDFQNAYIELGGLGERVLGFCFLNLPSNFSKGFQFNTDELNFPMENLCFAGLISMIDPPRTAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNDTAEDIAARLNIPISQVNNKSVKAIVVHGSELKDMESQQLDDILKSYKEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGIAMGITGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIILSIPLPLGTITILCIDLGTDMVPAISLAYESPESDIMKRLPRNPKTDNLVNNRLIGMAYGQIGMIQALAGFFTYFVILAENGFKPLDLLGIRLYWDDTQLNDLEDSYGQQWTYEQRKVVEFTCQTAFFISIVIVQWADLIICKTRRNSLFKQGMKNKILIFGLLEETVLAAFLSYVPGMDVSLRMYPLKINWWFCALPYSVLIFVYDEIRKLIIRRRPGGWLEKETYY
uniprot
proteins
ec_number
7.2.2.13
uniprot
proteins
function
FUNCTION: Sperm-specific catalytic alpha subunit of the Na(+)/K(+)-ATPase responsible for ATP-dependent Na(+)/K(+) exchange across the plasma membrane. Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze (By similarity). Plays an essential for sperm motility, capacitation, and male fertility by maintaining ionic gradients required for flagellar function and signaling (PubMed:21187400). {ECO:0000250|UniProtKB:Q64541, ECO:0000269|PubMed:21187400}.
uniprot
proteins
mass_dalton
114887
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIC subfamily
uniprot
proteins
pubmed
10555956
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21187400
uniprot
proteins
sequence_length
1032
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13733}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13733}. Note=In mature sperm, located in the principle piece of the sperm flagellum. {ECO:0000250|UniProtKB:Q13733}.
uniprot
proteins
transmembrane_region
TRANSMEM 101..125; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 137..158; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 298..321; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 327..352; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 781..803; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 809..831; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 854..877; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 927..948; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 957..979; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 991..1016; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q13733
uniprot
proteins