Smad7
entrez
81516
canonical
uniprot
O88406
canonical
ensembl
ENSRNOG00000018359
resolver
ensp
ENSRNOP00000024831
resolver
enst
ENSRNOT00000024831
resolver
genesymbol
Smad7
resolver
genesymbol_syn
Madh7
resolver
uniprot
A0A0G2JSQ5
resolver
uniprot
Q9QUG1
resolver
uniprot_entry
A0A0G2JSQ5_RAT
resolver
uniprot_entry
SMAD7_RAT
resolver
uniprot_sec
Q9QUG1
resolver
amino_acid_sequence
MFRTKRSALVRRLWRSRAPGGEDEEEGVGGGGGGGGLRGEGATDGRAYGAGGGGAGRAGCCLGKAVRGAKGHHHPHPPSSGAGAAGGAEADLKALTHSVLKKLKERQLELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPASAQPAQPPSSYSLPLLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHHLSRLCELESPPPPYSRYPMDFLKPTADCPDAVPSSDETGGTNYLAPGGLSDSQLLLEPGDRSHWCVVAYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEFMQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNSR
uniprot
proteins
function
FUNCTION: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000250|UniProtKB:O15105}.
uniprot
proteins
mass_dalton
46458
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-249 does not affect its stability, nuclear localization or inhibitory function in TGFB signaling; however it affects its ability to regulate transcription (By similarity). Phosphorylated by PDPK1 (By similarity). {ECO:0000250|UniProtKB:O15105, ECO:0000250|UniProtKB:O35253}.; PTM: Ubiquitinated by WWP1 (By similarity). Polyubiquitinated by RNF111, which is enhanced by AXIN1 and promotes proteasomal degradation. In response to TGF-beta, ubiquitinated by SMURF1; which promotes its degradation (By similarity). {ECO:0000250|UniProtKB:O15105, ECO:0000250|UniProtKB:O35253}.; PTM: Acetylation prevents ubiquitination and degradation mediated by SMURF1. {ECO:0000250|UniProtKB:O15105}.
uniprot
proteins
protein_family
Dwarfin/SMAD family
uniprot
proteins
pubmed
10656934
uniprot
proteins
pubmed
11181520
uniprot
proteins
sequence_length
426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O15105}. Cytoplasm {ECO:0000250|UniProtKB:O15105}. Note=Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm. TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta. {ECO:0000250|UniProtKB:O15105}.
uniprot
proteins