Pofut4
entrez
73068
canonical
uniprot
Q8BHC9
canonical
ensembl
ENSMUSG00000039357
resolver
ensp
ENSMUSP00000040370
resolver
enst
ENSMUST00000048016
resolver
genesymbol
Pofut4
resolver
genesymbol_syn
Fut11
resolver
uniprot
B2RRR9
resolver
uniprot
Q9CXS9
resolver
uniprot_entry
B2RRR9_MOUSE
resolver
uniprot_entry
OFUT4_MOUSE
resolver
uniprot_sec
Q9CXS9
resolver
amino_acid_sequence
MAARCTEAVLAALGVLSVCSASSSGSEASGEAEREEPWDGAVFRPPAALGAVGIARGPGSPPPGNREAVDLPVLLWWSPGLFPHFPGDSERIQCAHGACVASRDRRARADPRTRALLFYGTDFRAADAPLPRLAHQSWALLHEESPLNNFLLSHGPGIRLFNLTATFSRHSDYPLPLQWLPGAAYLRRPAPPPRERAEWRRRGYAPLLYLQSHCDVPSDRDRYVRELMRYIPVDSYGKCLQNREPPTVRLQDTATATTEDPELMAFLSRYKFHLALENAICNDYMTEKLWRPMHLGAVPVYRGSPSVRDWMPNNHSVILIDDFESPQKLAEFIDFLDKNDDEYMKYLAYKQPGGITNQFLLDNLEHREWGVNDPMLPNYLNGFECFVCDHELARLNAEKAHASSHGDIPVPEPRIAQSSHMNCPVPTPGFGKVEEIPENDSWKEMWLQDYWQGLYQGEALTAMIHNNETQQRKFWDYVHEIFMKRNKNL
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.1.221
uniprot
proteins
function
FUNCTION: Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1. Attaches fucose through an O-glycosidic linkage. O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion. Also shows minor alpha-(1,3)-fucosyltransferase activity toward activity toward biantennary N-glycan acceptors. However, this was tested with a library of synthetic substrates and this activity is unsure in vivo. {ECO:0000250|UniProtKB:Q495W5}.
uniprot
proteins
mass_dalton
55533
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q495W5}.
uniprot
proteins
protein_family
Glycosyltransferase 10 family
uniprot
proteins
pubmed
11698403
uniprot
proteins
pubmed
12370785
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19131326
uniprot
proteins
sequence_length
489
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q495W5}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..24; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins