Pdgfd
entrez
66018
canonical
uniprot
Q9EQT1
canonical
ensembl
ENSRNOG00000029148
resolver
ensembl
ENSRNOG00055005903
resolver
ensembl
ENSRNOG00060015604
resolver
ensembl
ENSRNOG00065002703
resolver
ensp
ENSRNOP00000068187
resolver
genesymbol
Pdgfd
resolver
genesymbol_syn
Iegf
resolver
genesymbol_syn
Scdgfb
resolver
uniprot_entry
PDGFD_RAT
resolver
amino_acid_sequence
MHRLILVSILVCANFCCYRDTFATPQSASIKALRNANLRRDESNHLTDLYRRDENIRVTGTGHVQSPRFPNSYPRNLLLTWRLHSQEKTRIQLAFDHQFGLEEAENDICRYDFVEVEDVSESSTVVRGRWCGHKEIPPRITSRTNQIKITFQSDDYFVAKPGFKIYYSFVEDFQPEAASEINWESVTSSFSGVSYHSPSVMDSTLTADALDKAIAEFDTVEDLLKYFNPASWQDDLENLYMDTPRYRGRSYHERKSKVDLDRLNDDVKRYSCTPRNHSVNLREELKLTNAVFFPRCLLVQRCGGNCGCGTLNWKSCTCSSGKTVKKYHEVLKFEPGHFKRRGKAKNMALVDIQLDHHERCDCICSSRPPR
uniprot
proteins
function
FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis (By similarity). May play an important role in control of lens epithelial cell proliferation. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. {ECO:0000250, ECO:0000269|PubMed:12937299, ECO:0000269|PubMed:15611105}.
uniprot
proteins
mass_dalton
42809
uniprot
proteins
post_translational_modification
PTM: Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
PDGF/VEGF growth factor family
uniprot
proteins
pubmed
11162582
uniprot
proteins
pubmed
11850188
uniprot
proteins
pubmed
12937299
uniprot
proteins
pubmed
15611105
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Released by platelets upon wounding. {ECO:0000250}.
uniprot
proteins