JOSD1
entrez
9929
canonical
uniprot
Q15040
canonical
ensembl
ENSG00000100221
resolver
ensp
ENSP00000216039
resolver
ensp
ENSP00000506752
resolver
ensp
ENSP00000536194
resolver
ensp
ENSP00000536195
resolver
ensp
ENSP00000536196
resolver
ensp
ENSP00000536197
resolver
ensp
ENSP00000536198
resolver
ensp
ENSP00000601729
resolver
enst
ENST00000216039
resolver
enst
ENST00000683374
resolver
enst
ENST00000866135
resolver
enst
ENST00000866136
resolver
enst
ENST00000866137
resolver
enst
ENST00000866138
resolver
enst
ENST00000866139
resolver
enst
ENST00000931670
resolver
genesymbol
JOSD1
resolver
genesymbol_syn
JSPH1
resolver
genesymbol_syn
KIAA0063
resolver
hgnc
HGNC:28953
resolver
uniprot
A8K712
resolver
uniprot_entry
JOS1_HUMAN
resolver
uniprot_sec
A8K712
resolver
amino_acid_sequence
MSCVPWKGDKAKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIFQRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKHHLRGKNCELLLVVPEEVEAHQSWRTDV
uniprot
proteins
ec_number
3.4.19.12
uniprot
proteins
function
FUNCTION: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity. {ECO:0000269|PubMed:21118805, ECO:0000269|PubMed:23625928}.
uniprot
proteins
mass_dalton
23198
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="C->A: Loss of deubiquitination activity, no change in subcellular location."; /evidence="ECO:0000269|PubMed:23625928
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated (By similarity). Ubiquitination activates deubiquitination activity in vitro. {ECO:0000250}.
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12486728
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17696782
uniprot
proteins
pubmed
21118805
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23625928
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7584044
uniprot
proteins
sequence_length
202
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23625928}. Cytoplasm {ECO:0000269|PubMed:23625928}. Note=Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding.
uniprot
proteins