Panx1
entrez
55991
canonical
uniprot
Q9JIP4
canonical
ensembl
ENSMUSG00000031934
resolver
ensp
ENSMUSP00000126405
resolver
enst
ENSMUST00000164273
resolver
genesymbol
Panx1
resolver
uniprot
Q5RL18
resolver
uniprot
Q9CXS7
resolver
uniprot_entry
PANX1_MOUSE
resolver
uniprot_sec
Q5RL18
resolver
uniprot_sec
Q9CXS7
resolver
amino_acid_sequence
MAIAHLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKSSLQSESGNLPLWLHKFFPYILLLFAILLYLPALFWRFSAAPHLCSDLKFIMEELDKVYNRAIKAAKSARDLDLRDGPGPPGVTENVGQSLWEISESHFKYPIVEQYLKTKKNSSHLIMKYISCRLVTFVVILLACIYLSYYFSLSSLSDEFLCSIKSGVLKNDSTIPDRFQCKLIAVGIFQLLSLINLIVYALLIPVVVYTFFIPFRQKTDILKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISELKSYKCLKVLENIKSNGQGIDPMLLLTNLGMIKMDIIDGKIPTSLQTKGEDQGSQRVEFKDLDLSSEAAANNGEKNSRQRLLNPSC
uniprot
proteins
function
FUNCTION: Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis (PubMed:30814251). Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate (PubMed:22311122). Can release ATP upon activation through phosphorylation or cleavage at C-terminus (PubMed:32238926). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (By similarity). {ECO:0000250|UniProtKB:Q96RD7, ECO:0000269|PubMed:22311122, ECO:0000269|PubMed:30814251, ECO:0000269|PubMed:32238926}.; FUNCTION: [Caspase-activated pannexin-1]: During apoptosis and after cleavage by caspases of the C-terminal tail, acts as a plasma membrane channel which mediates the regulated release of find-me signals, such as nucleotides ATP and UTP, and selective plasme membrane permeability. {ECO:0000269|PubMed:32238926}.
uniprot
proteins
mass_dalton
48167
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="C->A: Abolishes S-nitrosylation; when associated with Ala-346."; /evidence="ECO:0000269|PubMed:23033481"; MUTAGEN 254; /note="N->Q: Impairs glycosylation."; /evidence="ECO:0000269|PubMed:17925379"; MUTAGEN 346; /note="C->A: Abolishes S-nitrosylation; when associated with Ala-40."; /evidence="ECO:0000269|PubMed:23033481"; MUTAGEN 426; /note="C->A: No effect on S-nitrosylation."; /evidence="ECO:0000269|PubMed:23033481
uniprot
proteins
post_translational_modification
PTM: S-nitrosylation inhibits channel currents and ATP release. {ECO:0000269|PubMed:23033481}.; PTM: N-glycosylation may play a role in cell surface targeting (PubMed:17925379). Exists in three glycosylation states: non-glycosylated (GLY0), high-mannose glycosylated (GLY1), and fully mature glycosylated (GLY2) (By similarity). {ECO:0000250|UniProtKB:Q96RD7, ECO:0000269|PubMed:17925379}.; PTM: Phosphorylated at Tyr-198 by SRC. Phosphorylation activates ATP release. Constitutively phosphorylated in vascular smooth muscle cells. {ECO:0000269|PubMed:30814251}.; PTM: Cleaved by CASP3 and CASP7 during apoptosis. Cleavage opens the channel for the release of metabolites and induces plasma membrane permeability during apoptosis. {ECO:0000250|UniProtKB:Q96RD7}.
uniprot
proteins
protein_family
Pannexin family
uniprot
proteins
pubmed
10898987
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17925379
uniprot
proteins
pubmed
22311122
uniprot
proteins
pubmed
23033481
uniprot
proteins
pubmed
30814251
uniprot
proteins
pubmed
32238926
uniprot
proteins
sequence_length
426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22311122, ECO:0000269|PubMed:30814251}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96RD7}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}.
uniprot
proteins
transmembrane_region
TRANSMEM 41..61; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"; TRANSMEM 107..127; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"; TRANSMEM 278..298; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351
uniprot
proteins