NIN
entrez
51199
canonical
uniprot
Q8N4C6
canonical
ensembl
ENSG00000100503
resolver
ensp
ENSP00000324210
resolver
ensp
ENSP00000371472
resolver
ensp
ENSP00000374519
resolver
ensp
ENSP00000412391
resolver
ensp
ENSP00000431485
resolver
ensp
ENSP00000432924
resolver
ensp
ENSP00000436092
resolver
ensp
ENSP00000516509
resolver
ensp
ENSP00000542524
resolver
ensp
ENSP00000635371
resolver
ensp
ENSP00000719096
resolver
ensp
ENSP00000719097
resolver
ensp
ENSP00000719098
resolver
enst
ENST00000453196
resolver
enst
ENST00000476352
resolver
genesymbol
NIN
resolver
genesymbol_syn
KIAA1565
resolver
hgnc
HGNC:14906
resolver
uniprot
A6NDB8
resolver
uniprot
B7WPA3
resolver
uniprot
C9J066
resolver
uniprot
C9JSB6
resolver
uniprot
C9JSG2
resolver
uniprot
C9JXL2
resolver
uniprot
E9PN67
resolver
uniprot
Q5BKU3
resolver
uniprot
Q5XUU0
resolver
uniprot
Q6P0P6
resolver
uniprot
Q9BWU6
resolver
uniprot
Q9C012
resolver
uniprot
Q9C013
resolver
uniprot
Q9C014
resolver
uniprot
Q9H5I6
resolver
uniprot
Q9HAT7
resolver
uniprot
Q9HBY5
resolver
uniprot
Q9HCK7
resolver
uniprot
Q9UH61
resolver
uniprot_entry
C9J066_HUMAN
resolver
uniprot_entry
E9PN67_HUMAN
resolver
uniprot_entry
NIN_HUMAN
resolver
uniprot_entry
Q5XUU0_HUMAN
resolver
uniprot_sec
A6NDB8
resolver
uniprot_sec
B7WPA3
resolver
uniprot_sec
C9JSB6
resolver
uniprot_sec
C9JSG2
resolver
uniprot_sec
C9JXL2
resolver
uniprot_sec
Q5BKU3
resolver
uniprot_sec
Q6P0P6
resolver
uniprot_sec
Q9BWU6
resolver
uniprot_sec
Q9C012
resolver
uniprot_sec
Q9C013
resolver
uniprot_sec
Q9C014
resolver
uniprot_sec
Q9H5I6
resolver
uniprot_sec
Q9HAT7
resolver
uniprot_sec
Q9HBY5
resolver
uniprot_sec
Q9HCK7
resolver
uniprot_sec
Q9UH61
resolver
amino_acid_sequence
MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEQFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEGLNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTSHSSFNSSFTSLYCH
uniprot
proteins
disease_involvement
DISEASE: Seckel syndrome 7 (SCKL7) [MIM:614851]: A rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and intellectual disability. {ECO:0000269|PubMed:22933543}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}.
uniprot
proteins
mass_dalton
243249
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by AURKA/Aurora kinase A and PKA kinases but not CK2 or AURKB/ Aurora kinase B. {ECO:0000269|PubMed:12927815}.
uniprot
proteins
pubmed
10997877
uniprot
proteins
pubmed
11004522
uniprot
proteins
pubmed
11162463
uniprot
proteins
pubmed
11956314
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12403812
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12927815
uniprot
proteins
pubmed
14503922
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15147888
uniprot
proteins
pubmed
15190203
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18987736
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20596670
uniprot
proteins
pubmed
22933543
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23386061
uniprot
proteins
pubmed
28422092
uniprot
proteins
pubmed
9506584
uniprot
proteins
sequence_length
2090
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11004522, ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:12927815, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:15190203}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23386061}. Cell junction, desmosome {ECO:0000250|UniProtKB:Q61043}. Note=Component of the core centrosome. Arranged in a tubular conformation with an open and a closed end within the centrosome. In the mother centrosome, it localizes at both ends of the centrosome tube, including the site of centrosome duplication, while in the daughter centrosome it is present only at the closed end. Requires PCM1 for centrosome localization. Localizes to the subdistal appendage region of the centriole in a DCTN1-dependent manner. Localizes to desmosome cell-cell junctions in terminally differentiated epidermal and keratinocyte cells (By similarity). {ECO:0000250|UniProtKB:Q61043, ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:23386061}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000250|UniProtKB:Q61043}. Note=Seems to have a dominant-negative effect on localization of other isoforms, promoting their dissociation from the centrosome. {ECO:0000250|UniProtKB:Q61043}.
uniprot
proteins