Gata4
entrez
14463
canonical
uniprot
Q08369
canonical
ensembl
ENSMUSG00000021944
resolver
ensp
ENSMUSP00000066927
resolver
ensp
ENSMUSP00000113451
resolver
ensp
ENSMUSP00000113891
resolver
enst
ENSMUST00000067417
resolver
enst
ENSMUST00000118022
resolver
enst
ENSMUST00000121312
resolver
genesymbol
Gata4
resolver
genesymbol_syn
Gata-4
resolver
uniprot
B9EHF7
resolver
uniprot
E9PXW9
resolver
uniprot
F7C1M4
resolver
uniprot
P97491
resolver
uniprot
Q3UYJ1
resolver
uniprot
Q9QZK4
resolver
uniprot_entry
E9PXW9_MOUSE
resolver
uniprot_entry
F7C1M4_MOUSE
resolver
uniprot_entry
GATA4_MOUSE
resolver
uniprot_entry
Q3UYJ1_MOUSE
resolver
uniprot_sec
B9EHF7
resolver
uniprot_sec
P97491
resolver
uniprot_sec
Q9QZK4
resolver
amino_acid_sequence
MYQSLAMAANHGPPPGAYEAGGPGAFMHSAGAASSPVYVPTPRVPSSVLGLSYLQGGGSAAAAGTTSGGSSGAGPSGAGPGTQQGSPGWSQAGAEGAAYTPPPVSPRFSFPGTTGSLAAAAAAAAAREAAAYGSGGGAAGAGLAGREQYGRPGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPGRANPGRHPNLDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAGPAGETLPPSSGASSGNSSNATSSSSSSEEMRPIKTEPGLSSHYGHSSSMSQTFSTVSGHGPSIHPVLSALKLSPQGYASPVTQTSQASSKQDSWNSLVLADSHGDIITA
uniprot
proteins
function
FUNCTION: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (PubMed:33941892, PubMed:35182466). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (PubMed:9584153). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (By similarity). {ECO:0000250|UniProtKB:P43694, ECO:0000250|UniProtKB:P46152, ECO:0000269|PubMed:33941892, ECO:0000269|PubMed:35182466, ECO:0000269|PubMed:9584153}.
uniprot
proteins
mass_dalton
44580
uniprot
proteins
post_translational_modification
PTM: Methylation at Lys-299 attenuates transcriptional activity. {ECO:0000269|PubMed:22215809}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15542826
uniprot
proteins
pubmed
16199866
uniprot
proteins
pubmed
17584735
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22215809
uniprot
proteins
pubmed
33941892
uniprot
proteins
pubmed
35182466
uniprot
proteins
pubmed
7717974
uniprot
proteins
pubmed
8083222
uniprot
proteins
pubmed
8455608
uniprot
proteins
pubmed
9568714
uniprot
proteins
pubmed
9584153
uniprot
proteins
sequence_length
441
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P43694}.
uniprot
proteins