Cd79b
entrez
15985
canonical
uniprot
P15530
canonical
ensembl
ENSMUSG00000040592
resolver
ensp
ENSMUSP00000129029
resolver
enst
ENSMUST00000167143
resolver
genesymbol
Cd79b
resolver
genesymbol_syn
Igb
resolver
uniprot
Q4FJP4
resolver
uniprot_entry
CD79B_MOUSE
resolver
uniprot_sec
Q4FJP4
resolver
amino_acid_sequence
MATLVLSSMPCHWLLFLLLLFSGEPVPAMTSSDLPLNFQGSPCSQIWQHPRFAAKKRSSMVKFHCYTNHSGALTWFRKRGSQQPQELVSEEGRIVQTQNGSVYTLTIQNIQYEDNGIYFCKQKCDSANHNVTDSCGTELLVLGFSTLDQLKRRNTLKDGIILIQTLLIILFIIVPIFLLLDKDDGKAGMEEDHTYEGLNIDQTATYEDIVTLRTGEVKWSVGEHPGQE
uniprot
proteins
function
FUNCTION: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. {ECO:0000269|PubMed:10352267, ECO:0000269|PubMed:12356683, ECO:0000269|PubMed:15661879, ECO:0000269|PubMed:8175787}.
uniprot
proteins
mass_dalton
25726
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK. {ECO:0000269|PubMed:15335855, ECO:0000269|PubMed:7592958}.; PTM: Ubiquitinated by the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex composed of at least CUL3, KLHL6 and RBX1; leading to proteasomal degradation. {ECO:0000250|UniProtKB:P40259}.
uniprot
proteins
pubmed
10352267
uniprot
proteins
pubmed
10587346
uniprot
proteins
pubmed
11238609
uniprot
proteins
pubmed
12356683
uniprot
proteins
pubmed
1506682
uniprot
proteins
pubmed
15335855
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15661879
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20696394
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2508087
uniprot
proteins
pubmed
3137575
uniprot
proteins
pubmed
7592958
uniprot
proteins
pubmed
8175787
uniprot
proteins
pubmed
8976175
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10587346, ECO:0000269|PubMed:11238609, ECO:0000269|PubMed:15661879}; Single-pass type I membrane protein {ECO:0000269|PubMed:10587346, ECO:0000269|PubMed:11238609, ECO:0000269|PubMed:15661879}. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
uniprot
proteins
transmembrane_region
TRANSMEM 159..180; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins