Grk6
entrez
26385
canonical
uniprot
O70293
canonical
ensembl
ENSMUSG00000074886
resolver
ensp
ENSMUSP00000097081
resolver
ensp
ENSMUSP00000152968
resolver
ensp
ENSMUSP00000153344
resolver
ensp
ENSMUSP00000153623
resolver
ensp
ENSMUSP00000153668
resolver
enst
ENSMUST00000099482
resolver
enst
ENSMUST00000224653
resolver
enst
ENSMUST00000224995
resolver
enst
ENSMUST00000225925
resolver
genesymbol
Grk6
resolver
genesymbol_syn
GRK6-C
resolver
genesymbol_syn
Gprk6
resolver
uniprot
A0A286YDA5
resolver
uniprot
A0A286YDZ5
resolver
uniprot
A0A286YE10
resolver
uniprot
O70294
resolver
uniprot
O70295
resolver
uniprot
Q6DI67
resolver
uniprot
Q78DV7
resolver
uniprot
Q9EP84
resolver
uniprot_entry
A0A286YDA5_MOUSE
resolver
uniprot_entry
A0A286YDZ5_MOUSE
resolver
uniprot_entry
A0A286YE10_MOUSE
resolver
uniprot_entry
GRK6_MOUSE
resolver
uniprot_entry
Q78DV7_MOUSE
resolver
uniprot_entry
Q9EP84_MOUSE
resolver
uniprot_sec
O70294
resolver
uniprot_sec
O70295
resolver
uniprot_sec
Q6DI67
resolver
amino_acid_sequence
MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELTRCTAFLDGVSEYEVTPDEKRKACGRRLMQNFLSHTGPDLIPEVPRQLVSNCAQRLEQGPCKDLFQELTRLTHEYLSTAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVRNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVAEEYTDRFSSQARSLCSQLLSKDPAERLGCRGGGAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVDLEPTDQDFYQKFATGSVSIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPTAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL
uniprot
proteins
ec_number
2.7.11.16
uniprot
proteins
function
FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:12032308, PubMed:12718862, PubMed:14634128, PubMed:26886170, PubMed:38883814). Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:12032308, PubMed:12718862, PubMed:14634128, PubMed:26886170, PubMed:38883814). Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G protein-coupled receptor: LRP6 during Wnt signaling (in vitro) (By similarity). {ECO:0000250|UniProtKB:P43250, ECO:0000269|PubMed:12032308, ECO:0000269|PubMed:12718862, ECO:0000269|PubMed:14634128, ECO:0000269|PubMed:26886170, ECO:0000269|PubMed:38883814}.
uniprot
proteins
mass_dalton
65979
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
GPRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10506199
uniprot
proteins
pubmed
12032308
uniprot
proteins
pubmed
12718862
uniprot
proteins
pubmed
14634128
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26886170
uniprot
proteins
pubmed
38883814
uniprot
proteins
sequence_length
576
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
uniprot
proteins