Ngb
entrez
85382
canonical
uniprot
Q99JA8
canonical
ensembl
ENSRNOG00000011719
resolver
ensp
ENSRNOP00000016057
resolver
genesymbol
Ngb
resolver
uniprot
Q8VH38
resolver
uniprot
Q99N62
resolver
uniprot_entry
NGB_RAT
resolver
uniprot_sec
Q8VH38
resolver
uniprot_sec
Q99N62
resolver
amino_acid_sequence
MERPESELIRQSWRAVSRSPLEHGTVLFSRLFALEPSLLPLFQYNGRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLATLGRKHRAVGVRLSSFSTVGESLLYMLEKCLGPDFTPATRTAWSQLYGAVVQAMSRGWDGE
uniprot
proteins
ec_number
1.7.-.-
uniprot
proteins
function
FUNCTION: Monomeric globin with a bis-histidyl six-coordinate heme-iron atom through which it can bind dioxygen, carbon monoxide and nitric oxide. Could help transport oxygen and increase its availability to the metabolically active neuronal tissues, though its low quantity in tissues as well as its high affinity for dioxygen, which may limit its oxygen-releasing ability, argue against it. The ferrous/deoxygenated form exhibits a nitrite reductase activity and it could produce nitric oxide which in turn inhibits cellular respiration in response to hypoxia. In its ferrous/deoxygenated state, it may also exhibit GDI (Guanine nucleotide Dissociation Inhibitor) activity toward heterotrimeric G-alpha proteins, thereby regulating signal transduction to facilitate neuroprotective responses in the wake of hypoxia and associated oxidative stress. {ECO:0000250|UniProtKB:Q9NPG2}.
uniprot
proteins
mass_dalton
16981
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during hypoxia by ERK1/ERK2. Phosphorylation regulates the heme pocket hexacoordination preventing the association of His-64 with the heme metal center. Thereby, promotes the access of dioxygen and nitrite to the heme and stimulates the nitrite reductase activity. Phosphorylation during hypoxia is stabilized by 14-3-3 proteins. {ECO:0000250|UniProtKB:Q9NPG2}.
uniprot
proteins
protein_family
Globin family
uniprot
proteins
pubmed
11725647
uniprot
proteins
pubmed
11820779
uniprot
proteins
sequence_length
151
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9ER97}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q9ER97}. Note=Enriched in mitochondrial matrix upon oxygen-glucose deprivation. {ECO:0000250|UniProtKB:Q9ER97}.
uniprot
proteins