MTARC1
entrez
64757
canonical
uniprot
Q5VT66
canonical
ensembl
ENSG00000186205
resolver
ensp
ENSP00000355877
resolver
ensp
ENSP00000385327
resolver
ensp
ENSP00000511593
resolver
genesymbol
MTARC1
resolver
genesymbol_syn
MARC1
resolver
genesymbol_syn
MOSC1
resolver
hgnc
HGNC:26189
resolver
uniprot
A8K447
resolver
uniprot
B2D078
resolver
uniprot
Q5VVS9
resolver
uniprot
Q5VVT0
resolver
uniprot
Q5VVT1
resolver
uniprot
Q8N9P5
resolver
uniprot
Q96FN8
resolver
uniprot
Q9H6C7
resolver
uniprot_entry
MARC1_HUMAN
resolver
uniprot_sec
A8K447
resolver
uniprot_sec
B2D078
resolver
uniprot_sec
Q5VVS9
resolver
uniprot_sec
Q5VVT0
resolver
uniprot_sec
Q5VVT1
resolver
uniprot_sec
Q8N9P5
resolver
uniprot_sec
Q96FN8
resolver
uniprot_sec
Q9H6C7
resolver
amino_acid_sequence
MGAAGSSALARFVLLAQSRPGWLGVAALGLTAVALGAVAWRRAWPTRRRRLLQQVGTVAQLWIYPVKSCKGVPVSEAECTAMGLRSGNLRDRFWLVINQEGNMVTARQEPRLVLISLTCDGDTLTLSAAYTKDLLLPIKTPTTNAVHKCRVHGLEIEGRDCGEATAQWITSFLKSQPYRLVHFEPHMRPRRPHQIADLFRPKDQIAYSDTSPFLILSEASLADLNSRLEKKVKATNFRPNIVISGCDVYAEDSWDELLIGDVELKRVMACSRCILTTVDPDTGVMSRKEPLETLKSYRQCDPSERKLYGKSPLFGQYFVLENPGTIKVGDPVYLLGQ
uniprot
proteins
ec_number
1.7.-.-
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:19053771, PubMed:21029045, PubMed:30397129). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:19053771). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:19053771, PubMed:21029045). {ECO:0000269|PubMed:19053771, ECO:0000269|PubMed:21029045, ECO:0000269|PubMed:30397129}.
uniprot
proteins
mass_dalton
37499
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19053771
uniprot
proteins
pubmed
21029045
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23086957
uniprot
proteins
pubmed
24423752
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
25807930
uniprot
proteins
pubmed
30397129
uniprot
proteins
sequence_length
337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:23086957}; Single-pass type II membrane protein {ECO:0000269|PubMed:23086957}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Mitochondrial import is mediated by AA 1-40 and requires ATP.
uniprot
proteins
transmembrane_region
TRANSMEM 21..40; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins