Dhodh
entrez
56749
canonical
uniprot
O35435
canonical
ensembl
ENSMUSG00000031730
resolver
ensp
ENSMUSP00000115934
resolver
enst
ENSMUST00000123605
resolver
genesymbol
Dhodh
resolver
uniprot_entry
PYRD_MOUSE
resolver
amino_acid_sequence
MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR
uniprot
proteins
ec_number
1.3.5.2
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway. {ECO:0000250|UniProtKB:Q02127}.
uniprot
proteins
mass_dalton
42700
uniprot
proteins
pathway_participation
PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.
uniprot
proteins
post_translational_modification
PTM: The uncleaved transit peptide is required for mitochondrial targeting and proper membrane integration. {ECO:0000250}.
uniprot
proteins
protein_family
Dihydroorotate dehydrogenase family
uniprot
proteins
protein_family
Type 2 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q02127}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q02127}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..30; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins