Grsf1
entrez
231413
canonical
uniprot
Q8C5Q4
canonical
ensembl
ENSMUSG00000044221
resolver
ensp
ENSMUSP00000077972
resolver
ensp
ENSMUSP00000108860
resolver
enst
ENSMUST00000078945
resolver
enst
ENSMUST00000113234
resolver
genesymbol
Grsf1
resolver
uniprot
E9Q179
resolver
uniprot
Q8BR05
resolver
uniprot
Q8BRG7
resolver
uniprot_entry
E9Q179_MOUSE
resolver
uniprot_entry
GRSF1_MOUSE
resolver
uniprot_sec
Q8BR05
resolver
uniprot_sec
Q8BRG7
resolver
amino_acid_sequence
MAGTRWVLGALLRGCGCNCSSCRRTGAACLPFYSAAGTFPSGVSGRRRLLLLLGAAAAAASQTRGLQLGPAAAGRLAGPIPARPSAAAAAAASYSALRAPLFPRSLAAAAGPARGYSQESKTTYLEDLPPLPEYELSPSKLGDEVDDVYLIRAQGLPWSCTVEDVLNFFSDCRIRNSENGIHFLLNRDGKRRGDALIEMESEQDVQKALEKHRMYMGQRYVEVYEINNEDVDALMKSLQVKPSPVLSDGVVRLRGLPYSCNEKDIVDFFAGLNIVDITFVMDYRGRRKTGEAYVQFEEPEMANQALLKHREEIGNRYIEIFPSRRNEVRTHVGSHKGKKMTSSPPTKYITEPEVVFEEHEVNEDIRPMTAFESDKEIELPKEMSEKLPEAVDFGTLPSLHFVHMRGLPFQANAQDIINFFAPLKPVRITMEYSSSGKATGEADVHFDTHEDAVAAMLKDRSHVQHRYIELFLNSCPKGK
uniprot
proteins
function
FUNCTION: Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences. Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome. G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA. {ECO:0000250|UniProtKB:Q12849}.
uniprot
proteins
mass_dalton
53076
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q12849}. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000250|UniProtKB:Q12849}.
uniprot
proteins