POR
entrez
5447
canonical
uniprot
P16435
canonical
ensembl
ENSG00000127948
resolver
ensp
ENSP00000419970
resolver
ensp
ENSP00000516443
resolver
ensp
ENSP00000516444
resolver
ensp
ENSP00000516445
resolver
ensp
ENSP00000580605
resolver
ensp
ENSP00000580608
resolver
ensp
ENSP00000580609
resolver
ensp
ENSP00000580610
resolver
ensp
ENSP00000580611
resolver
ensp
ENSP00000580612
resolver
ensp
ENSP00000580614
resolver
ensp
ENSP00000580618
resolver
ensp
ENSP00000580619
resolver
ensp
ENSP00000580620
resolver
ensp
ENSP00000580621
resolver
ensp
ENSP00000580622
resolver
ensp
ENSP00000580623
resolver
ensp
ENSP00000603109
resolver
ensp
ENSP00000614671
resolver
ensp
ENSP00000614672
resolver
ensp
ENSP00000614673
resolver
ensp
ENSP00000614674
resolver
ensp
ENSP00000614675
resolver
enst
ENST00000461988
resolver
enst
ENST00000706545
resolver
enst
ENST00000706546
resolver
enst
ENST00000706547
resolver
enst
ENST00000910546
resolver
enst
ENST00000910549
resolver
enst
ENST00000910550
resolver
enst
ENST00000910551
resolver
enst
ENST00000910552
resolver
enst
ENST00000910553
resolver
enst
ENST00000910555
resolver
enst
ENST00000910559
resolver
enst
ENST00000910561
resolver
enst
ENST00000910562
resolver
enst
ENST00000910563
resolver
enst
ENST00000910564
resolver
enst
ENST00000933050
resolver
enst
ENST00000944612
resolver
enst
ENST00000944613
resolver
enst
ENST00000944614
resolver
enst
ENST00000944615
resolver
enst
ENST00000944616
resolver
genesymbol
POR
resolver
genesymbol_syn
CYPOR
resolver
hgnc
HGNC:9208
resolver
uniprot
A0A9L9PY49
resolver
uniprot
Q16455
resolver
uniprot
Q197M5
resolver
uniprot
Q8N181
resolver
uniprot
Q9H3M8
resolver
uniprot
Q9UDT3
resolver
uniprot_entry
A0A9L9PY49_HUMAN
resolver
uniprot_entry
NCPR_HUMAN
resolver
uniprot_sec
Q16455
resolver
uniprot_sec
Q197M5
resolver
uniprot_sec
Q8N181
resolver
uniprot_sec
Q9H3M8
resolver
uniprot_sec
Q9UDT3
resolver
amino_acid_sequence
MGDSHVDTSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKKKEEVPEFTKIQTLTSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTKGRYSLDVWS
uniprot
proteins
disease_involvement
DISEASE: Antley-Bixler syndrome, with genital anomalies and disordered steroidogenesis (ABS1) [MIM:201750]: A disease characterized by the association of Antley-Bixler syndrome with steroidogenesis defects and abnormal genitalia. Antley-Bixler syndrome is characterized by craniosynostosis, radiohumeral synostosis present from the perinatal period, midface hypoplasia, choanal stenosis or atresia, femoral bowing and multiple joint contractures. {ECO:0000269|PubMed:14758361, ECO:0000269|PubMed:15264278, ECO:0000269|PubMed:15483095}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Disordered steroidogenesis due to cytochrome P450 oxidoreductase deficiency (DISPORD) [MIM:613571]: A disorder resulting in a rare variant of congenital adrenal hyperplasia, with apparent combined P450C17 and P450C21 deficiency and accumulation of steroid metabolites. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome. {ECO:0000269|PubMed:14758361, ECO:0000269|PubMed:15220035}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.6.2.4
uniprot
proteins
function
FUNCTION: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. {ECO:0000255|HAMAP-Rule:MF_03212}.
uniprot
proteins
mass_dalton
76690
uniprot
proteins
protein_family
NADPH--cytochrome P450 reductase family; Flavodoxin family; Flavoprotein pyridine nucleotide cytochrome reductase family
uniprot
proteins
pubmed
10048323
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14758361
uniprot
proteins
pubmed
15220035
uniprot
proteins
pubmed
15264278
uniprot
proteins
pubmed
15483095
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1550342
uniprot
proteins
pubmed
19483672
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21808038
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2513880
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27610946
uniprot
proteins
sequence_length
677
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03212}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03212}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03212}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03212
uniprot
proteins