Fam107a
entrez
268709
canonical
uniprot
Q78TU8
canonical
ensembl
ENSMUSG00000021750
resolver
ensp
ENSMUSP00000045513
resolver
ensp
ENSMUSP00000112769
resolver
ensp
ENSMUSP00000114015
resolver
ensp
ENSMUSP00000313363
resolver
ensp
ENSMUSP00000313364
resolver
ensp
ENSMUSP00000313365
resolver
ensp
ENSMUSP00000313369
resolver
enst
ENSMUST00000036070
resolver
enst
ENSMUST00000120411
resolver
enst
ENSMUST00000121887
resolver
genesymbol
Fam107a
resolver
uniprot
A0A5S8E879
resolver
uniprot_entry
A0A5S8E879_MOUSE
resolver
uniprot_entry
F107A_MOUSE
resolver
amino_acid_sequence
MYSEIQRERADIEGLMARPEYREWNSELIKPKKLLNPVKASRSHQELHRELLMNHKRGLGMDSKPELQRVLEHRRRNQLIKKKEEELEAKRMQCPFKQELLRRQQRLNQLENPPQRDEDHAPEFIKVRENLRRITTLTSEERAL
uniprot
proteins
function
FUNCTION: Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics (PubMed:21969592). Mediates polymerization of globular actin to F-actin (PubMed:21969592). Also binds to, stabilizes and bundles F-actin (PubMed:21969592). Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (PubMed:21969592). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development (By similarity). {ECO:0000250|UniProtKB:O95990, ECO:0000269|PubMed:21969592}.
uniprot
proteins
mass_dalton
17510
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21969592
uniprot
proteins
pubmed
25637808
uniprot
proteins
sequence_length
144
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95990}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:21969592}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:O95990}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O95990}. Synapse {ECO:0000269|PubMed:21969592}. Note=Colocalizes with F-actin (PubMed:21969592). Colocalizes with F-actin and COMMD1 in the nucleus. Colocalizes with MAP1A along actin stress fibers and membrane ruffles (By similarity). {ECO:0000250|UniProtKB:O95990, ECO:0000269|PubMed:21969592}.
uniprot
proteins