Mark3
entrez
17169
canonical
uniprot
Q03141
canonical
ensembl
ENSMUSG00000007411
resolver
ensp
ENSMUSP00000074757
resolver
ensp
ENSMUSP00000082017
resolver
ensp
ENSMUSP00000152483
resolver
ensp
ENSMUSP00000152727
resolver
ensp
ENSMUSP00000287734
resolver
ensp
ENSMUSP00000287736
resolver
ensp
ENSMUSP00000287738
resolver
ensp
ENSMUSP00000287739
resolver
ensp
ENSMUSP00000287746
resolver
ensp
ENSMUSP00000287754
resolver
ensp
ENSMUSP00000287774
resolver
ensp
ENSMUSP00000287797
resolver
ensp
ENSMUSP00000287798
resolver
enst
ENSMUST00000221753
resolver
genesymbol
Mark3
resolver
genesymbol_syn
Emk2
resolver
genesymbol_syn
Mpk10
resolver
uniprot
A0A1Y7VNZ6
resolver
uniprot
Q3TM40
resolver
uniprot
Q3V1U3
resolver
uniprot
Q8C6G9
resolver
uniprot
Q8R375
resolver
uniprot
Q9JKE4
resolver
uniprot_entry
A0A1Y7VNZ6_MOUSE
resolver
uniprot_entry
MARK3_MOUSE
resolver
uniprot_sec
Q3TM40
resolver
uniprot_sec
Q3V1U3
resolver
uniprot_sec
Q8C6G9
resolver
uniprot_sec
Q8R375
resolver
uniprot_sec
Q9JKE4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-211. Inhibited by phosphorylation on Thr-564 (By similarity). {ECO:0000250|UniProtKB:P27448}.
uniprot
proteins
amino_acid_sequence
MSTRTPLPTVNERDTENHISHGDGRQEVTSRTGRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSAELDASDSSSSSNLSLAKVRPNSDLSNSTGQSPHHKGQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGIPSRKSSSSAVGGKGIAPASPMLGNAGNPNKADIPERKKSPAVPSSNTASGGMTRRNTYVCSERCAADRHSVIQNGKENSAIPDERTPVASTHSISSATTPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSSEQKDENREAKPRSLRFTWSMKTTSSMDPSDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1. {ECO:0000250|UniProtKB:P27448}.
uniprot
proteins
mass_dalton
84390
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity (By similarity). {ECO:0000250|UniProtKB:P27448}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SNF1 subfamily
uniprot
proteins
pubmed
1281307
uniprot
proteins
pubmed
12941695
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17075132
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
753
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P27448}; Peripheral membrane protein {ECO:0000250|UniProtKB:P27448}. Cell projection, dendrite {ECO:0000250|UniProtKB:P27448}. Cytoplasm {ECO:0000250|UniProtKB:P27448}.
uniprot
proteins