Ipo11
entrez
76582
canonical
uniprot
Q8K2V6
canonical
ensembl
ENSMUSG00000042590
resolver
ensp
ENSMUSP00000079667
resolver
ensp
ENSMUSP00000140046
resolver
genesymbol
Ipo11
resolver
genesymbol_syn
Ranbp11
resolver
uniprot
Q8BU45
resolver
uniprot
Q8K0B4
resolver
uniprot_entry
IPO11_MOUSE
resolver
uniprot_sec
Q8BU45
resolver
uniprot_sec
Q8K0B4
resolver
amino_acid_sequence
MDLNSASSVVLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTNHTLDINVRWLAVLYFKHGIDRYWRRVAPHALSEEEKSTLRAGLITNFNEPINQIATQIAVLIAKVARLDCPRQWPELIPTLVESVKVQDDLRQHRALLTFYHVTKTLASKRLAADRKLFYDLASGIYNFACSLWNHHTDTFLQHVSSGNEAAVLSSLERTLLSLKVLRKLTVNGFVEPHKNMEVMGFLHGIFERLKQFLECSRSIGTDNVCRDRLEKTIILFTKVLLDFLDQHPISFTPLIQRSLEFSVSYVFTEVGEGVTFERFIVQCMNLIKMIVKNYAYKPSKNFEDSSPETLEAHKIKMAFFTYPTLTEICRRLVSHYFLLTEEELTMWEEDPEGFTVEETGGDSWKYSLRPCTEVLFIDIFHEYNQTLTPVLLEMMQTLEGPTNVEDMNALLIKDAVYNAVGLAAFELFDSVDFDQWFKTQLLPELQVSHNRYKPLRRRVIWLIGQWISVKFKSDLRPMLYEAICNLLQDQDLVVRIETATTLKLTVDDFEFRTDQFLPYLETMFTLLFQLLQQVTECDTKMHVLHVLSCVIERVNVQIRPYVGCLVQYLPLLWKQSEEHNMLRCAILTTLIHLVQGLGADSKNLYPFLLPVIQLSTDVSQPPHVYLLEDGLELWLVTLENSPCVTPELLRIFQNMSPLLELSSENLRTCFKIINGYIFLSSTEFLQTYAAGLCQSFYELLPEITTEGQVQVLKVVENALKVNPVLGPQMFQRILPCVFRGVIEGERYPVVMSIYLAVMGRVLLQNTSFFSSLLNEMGHEFNQEMDQLLGNVIEMWVDRMDNITQPERKKLSALALLSLLPSDNSVIQDKFCGIINISVEALHDVMTEDPETRTYKDCMLMSQHEEPKVTEDEEPPTEQDKRKKMLALKDPVHTVSLQQFIYEKLKAQQEILGEQGFQSLMETVDTEIVTQLQEFLQGF
uniprot
proteins
function
FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPL12, and of UBE2E3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11809816}.
uniprot
proteins
mass_dalton
112416
uniprot
proteins
protein_family
Importin beta family
uniprot
proteins
pubmed
11809816
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
975
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins