Rexo2
entrez
300689
canonical
uniprot
Q5U1X1
canonical
ensembl
ENSRNOG00000018939
resolver
ensp
ENSRNOP00000071290
resolver
ensp
ENSRNOP00000078478
resolver
ensp
ENSRNOP00000087210
resolver
enst
ENSRNOT00000087265
resolver
enst
ENSRNOT00000109200
resolver
genesymbol
Rexo2
resolver
genesymbol_syn
Smfn
resolver
uniprot
A0A0G2K038
resolver
uniprot
A0A8I5ZKY7
resolver
uniprot_entry
A0A0G2K038_RAT
resolver
uniprot_entry
A0A8I5ZKY7_RAT
resolver
uniprot_entry
ORN_RAT
resolver
amino_acid_sequence
MLGVSLGARLLRGVGGRRGQFGARGVSEGSAAMAAGESMAQRMVWVDLEMTGLDIEKDQIIEMACLITDSDLNILAEGPNLIIKQPDELLDSMSDWCKEHHGKSGLTKAVKESTVTLQQAEYEFLSFVRQQTPPGLCPLAGNSVHADKKFLDKHMPQFMKHLHYRIIDVSTVKELCRRWYPEDYEFAPKKAASHRALDDISESIKELQFYRNNIFKKKTDEKKRKIIENGENEKPVS
uniprot
proteins
ec_number
3.1.15.-
uniprot
proteins
function
FUNCTION: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (By similarity). Binds and degrades longer oligonucleotides with a lower affinity (By similarity). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (By similarity). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (By similarity). Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:Q9D8S4, ECO:0000250|UniProtKB:Q9Y3B8}.
uniprot
proteins
mass_dalton
26752
uniprot
proteins
protein_family
Oligoribonuclease family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q9Y3B8}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q9Y3B8}. Mitochondrion {ECO:0000250|UniProtKB:Q9Y3B8}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y3B8}. Nucleus {ECO:0000250|UniProtKB:Q9Y3B8}.
uniprot
proteins