Slc8b1
entrez
170756
canonical
uniprot
Q925Q3
canonical
ensembl
ENSMUSG00000032754
resolver
ensp
ENSMUSP00000064714
resolver
ensp
ENSMUSP00000075428
resolver
ensp
ENSMUSP00000107521
resolver
ensp
ENSMUSP00000261315
resolver
ensp
ENSMUSP00000261324
resolver
genesymbol
Slc8b1
resolver
genesymbol_syn
Nckx6
resolver
genesymbol_syn
Nclx
resolver
genesymbol_syn
Slc24a6
resolver
uniprot
Q3U067
resolver
uniprot
Q80XM7
resolver
uniprot_entry
NCLX_MOUSE
resolver
uniprot_sec
Q3U067
resolver
uniprot_sec
Q80XM7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the sodium/calcium exchanger inhibitor CGP-37157 (PubMed:28445457). Strongly inhibited by zinc (By similarity). {ECO:0000250|UniProtKB:Q6J4K2}.
uniprot
proteins
amino_acid_sequence
MASRWLALLWAPVFLCVALILETASGTGDPSTKAHGHIQFSAGSVNQTAMADCRAVCGLNTSDRCDFVRRNPDCRSEAGYLDYLEGIFCYFPPNLLPLAITLYVFWLLYLFLILGVTAAKFFCPNLSAISTNLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPRTAGLAIGALFGAGVLVTTVVAGGITILHPFMAASRPFLRDIAFYMVAVFLTFTALYLGRITLTWALGYLGLYVFYVVTVIICTWVYQRQRSRSLVHSISETPELLSESEEDQMSSNTNSYDYGDEYRPLLLGRETTVQILIQALNPLDYRKWRTQSISWRVLKVVKLPVEFLLLLTVPVVDPDKDDRNWKRPLNCLQLVISPLVLVLTLQSGVYGIYEIGGLLPVWAVVVIVGTALASVTFFATSNREPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVIFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQIIRNHVVEVKLEPDGLLVWVLASALGLSLIFSLVSVPLQCFQLSKAYGLCLLLFYICFLVVVLLTEFGVIHLKKA
uniprot
proteins
function
FUNCTION: Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:28445457). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (PubMed:24067497, PubMed:28445457). Mitochondrial calcium export is ph-dependent (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (By similarity). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (By similarity). Involved in B-lymphocyte chemotaxis (PubMed:27328625). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (By similarity). In contrast to other members of the family its function is independent of K(+) (By similarity). {ECO:0000250|UniProtKB:Q6AXS0, ECO:0000250|UniProtKB:Q6J4K2, ECO:0000269|PubMed:20018762, ECO:0000269|PubMed:24067497, ECO:0000269|PubMed:27328625, ECO:0000269|PubMed:28445457}.
uniprot
proteins
mass_dalton
64365
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-258 by PKA prevents calcium overload. {ECO:0000250|UniProtKB:Q6J4K2}.
uniprot
proteins
protein_family
Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family
uniprot
proteins
protein_family
SLC24A subfamily
uniprot
proteins
pubmed
12080145
uniprot
proteins
pubmed
14625281
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20018762
uniprot
proteins
pubmed
22677781
uniprot
proteins
pubmed
24067497
uniprot
proteins
pubmed
27328625
uniprot
proteins
pubmed
28445457
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:20018762, ECO:0000269|PubMed:24067497}; Multi-pass membrane protein {ECO:0000269|PubMed:20018762}. Note=Mainly localizes to mitochondrion inner membrane (PubMed:20018762).; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:14625281}; Multi-pass membrane protein {ECO:0000269|PubMed:14625281}.
uniprot
proteins
transmembrane_region
TRANSMEM 96..132; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 137..162; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 166..192; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 200..221; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 227..255; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 356..373; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 389..409; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 418..450; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 455..480; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 485..514; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 527..549; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 555..576; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q6AXS0
uniprot
proteins