P36394
uniprot
P36394
canonical
amino_acid_sequence
MEGHVKRPMNAFMVWSRGERRKLAQQNPSMQNSEISKHLGYQWKSLTEAEKRPFFQEAQRLKTLHREKYPNYKYQPHRRVKVPQRSYTLQREVASTKLYNLLQWDNNLHTIIYGQDWARAAHQSSKNQKSIYLQPVDIPTGYPLQQKQQHQQQQHVHLQQQQQQQHQFH
uniprot
proteins
function
FUNCTION: Transcriptional regulator that controls a genetic switch in male development (PubMed:16414182, PubMed:16996051). It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (PubMed:16414182, PubMed:16996051). Involved in different aspects of gene regulation including promoter activation or repression (PubMed:16488877). Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity). SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending (By similarity). Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (PubMed:16488877). {ECO:0000250|UniProtKB:Q05066, ECO:0000269|PubMed:16488877, ECO:0000303|PubMed:16414182, ECO:0000303|PubMed:16996051}.
uniprot
proteins
mass_dalton
20465
uniprot
proteins
post_translational_modification
PTM: Acetylation of Lys-81 contributes to its nuclear localization and enhances its interaction with KPNB1. Deacetylated by HDAC3. {ECO:0000250|UniProtKB:Q05066}.
uniprot
proteins
protein_family
SRY family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16414182
uniprot
proteins
pubmed
16488877
uniprot
proteins
pubmed
16904257
uniprot
proteins
pubmed
16996051
uniprot
proteins
pubmed
8162230
uniprot
proteins
pubmed
9203057
uniprot
proteins
pubmed
9571157
uniprot
proteins
sequence_length
169
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q05066}. Cytoplasm {ECO:0000269|PubMed:16488877}. Nucleus {ECO:0000269|PubMed:16488877}. Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization. Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus. Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH). {ECO:0000250|UniProtKB:Q05066, ECO:0000250|UniProtKB:Q05738}.
uniprot
proteins