LNPEP
entrez
4012
canonical
uniprot
Q9UIQ6
canonical
ensembl
ENSG00000113441
resolver
ensp
ENSP00000231368
resolver
ensp
ENSP00000379117
resolver
ensp
ENSP00000552802
resolver
genesymbol
LNPEP
resolver
genesymbol_syn
OTASE
resolver
hgnc
HGNC:6656
resolver
uniprot
O00769
resolver
uniprot
Q15145
resolver
uniprot
Q59H76
resolver
uniprot
Q9TNQ2
resolver
uniprot
Q9TNQ3
resolver
uniprot
Q9UIQ7
resolver
uniprot_entry
LCAP_HUMAN
resolver
uniprot_sec
O00769
resolver
uniprot_sec
Q15145
resolver
uniprot_sec
Q59H76
resolver
uniprot_sec
Q9TNQ2
resolver
uniprot_sec
Q9TNQ3
resolver
uniprot_sec
Q9UIQ7
resolver
amino_acid_sequence
MEPFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVVAVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL
uniprot
proteins
ec_number
3.4.11.3
uniprot
proteins
function
FUNCTION: Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:11707427, ECO:0000269|PubMed:1731608}.
uniprot
proteins
mass_dalton
117349
uniprot
proteins
post_translational_modification
PTM: The pregnancy serum form is derived from the membrane-bound form by proteolytic processing.; PTM: N-glycosylated. {ECO:0000269|PubMed:19349973}.
uniprot
proteins
protein_family
Peptidase M1 family
uniprot
proteins
pubmed
10759854
uniprot
proteins
pubmed
11389728
uniprot
proteins
pubmed
11707427
uniprot
proteins
pubmed
1731608
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
41882355
uniprot
proteins
pubmed
8119729
uniprot
proteins
pubmed
8550619
uniprot
proteins
pubmed
9177475
uniprot
proteins
sequence_length
1025
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11389728}; Single-pass type II membrane protein {ECO:0000269|PubMed:11389728}. Note=In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.; SUBCELLULAR LOCATION: [Leucyl-cystinyl aminopeptidase, pregnancy serum form]: Secreted. Note=During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.
uniprot
proteins
transmembrane_region
TRANSMEM 111..131; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins