GP2
entrez
2813
canonical
uniprot
P55259
canonical
ensembl
ENSG00000169347
resolver
ensp
ENSP00000304044
resolver
ensp
ENSP00000343861
resolver
ensp
ENSP00000370765
resolver
ensp
ENSP00000370767
resolver
genesymbol
GP2
resolver
hgnc
HGNC:4441
resolver
uniprot
A6NFM9
resolver
uniprot
A6NJA8
resolver
uniprot
B7Z1G2
resolver
uniprot
Q13338
resolver
uniprot
Q9UIF1
resolver
uniprot_entry
B7Z1G2_HUMAN
resolver
uniprot_entry
GP2_HUMAN
resolver
uniprot_sec
A6NFM9
resolver
uniprot_sec
A6NJA8
resolver
uniprot_sec
Q13338
resolver
uniprot_sec
Q9UIF1
resolver
amino_acid_sequence
MPHLMERMVGSGLLWLALVSCILTQASAVQRGYGNPIEASSYGLDLDCGAPGTPEAHVCFDPCQNYTLLDEPFRSTENSAGSQGCDKNMSGWYRFVGEGGVRMSETCVQVHRCQTDAPMWLNGTHPALGDGITNHTACAHWSGNCCFWKTEVLVKACPGGYHVYRLEGTPWCNLRYCTVPRDPSTVEDKCEKACRPEEECLALNSTWGCFCRQDLNSSDVHSLQPQLDCGPREIKVKVDKCLLGGLGLGEEVIAYLRDPNCSSILQTEERNWVSVTSPVQASACRNILERNQTHAIYKNTLSLVNDFIIRDTILNINFQCAYPLDMKVSLQAALQPIVSSLNVSVDGNGEFIVRMALFQDQNYTNPYEGDAVELSVESVLYVGAILEQGDTSRFNLVLRNCYATPTEDKADLVKYFIIRNSCSNQRDSTIHVEENGQSSESRFSVQMFMFAGHYDLVFLHCEIHLCDSLNEQCQPSCSRSQVRSEVPAIDLARVLDLGPITRRGAQSPGVMNGTPSTAGFLVAWPMVLLTVLLAWLF
uniprot
proteins
function
FUNCTION: Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response. {ECO:0000269|PubMed:35273390, ECO:0000305|PubMed:19907495}.
uniprot
proteins
mass_dalton
59480
uniprot
proteins
mutagenesis
MUTAGEN 65; /note="N->A: Impaired interaction with fimH."; /evidence="ECO:0000269|PubMed:35273390
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Glycosylated Asn-65 may be required for interaction with bacterial adhesin fimH. {ECO:0000269|PubMed:35273390}.
uniprot
proteins
pubmed
10760606
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
19907495
uniprot
proteins
pubmed
35273390
uniprot
proteins
pubmed
8666297
uniprot
proteins
sequence_length
537
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Zymogen granule membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Secreted {ECO:0000269|PubMed:10760606}. Cell membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Apical cell membrane {ECO:0000250|UniProtKB:Q9D733}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Membrane raft {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Endosome {ECO:0000250|UniProtKB:Q9D733}. Note=Secreted, after cleavage, in the pancreatic juice. {ECO:0000305|PubMed:10760606}.
uniprot
proteins