HOOK1
entrez
51361
canonical
uniprot
Q9UJC3
canonical
ensembl
ENSG00000134709
resolver
ensp
ENSP00000360252
resolver
ensp
ENSP00000509189
resolver
ensp
ENSP00000671822
resolver
ensp
ENSP00000705689
resolver
genesymbol
HOOK1
resolver
hgnc
HGNC:19884
resolver
uniprot
A8K8E9
resolver
uniprot
A8MU44
resolver
uniprot
B4DX15
resolver
uniprot
O60561
resolver
uniprot
Q5TG44
resolver
uniprot_entry
HOOK1_HUMAN
resolver
uniprot_sec
A8K8E9
resolver
uniprot_sec
A8MU44
resolver
uniprot_sec
B4DX15
resolver
uniprot_sec
O60561
resolver
uniprot_sec
Q5TG44
resolver
amino_acid_sequence
MEETQPPPQPKLPLCDSLMIWLQTFNTASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWLSRIKEDVGDNWRIKASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRLLQLILGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDYEEKLIVSAWYNKSLAFQKLGMESRLVSGGGACSDTGACTPARSFLAQQRHITNTRRNLSVKVPATTSD
uniprot
proteins
function
FUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:18799622, PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). {ECO:0000250|UniProtKB:Q8BIL5, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}.
uniprot
proteins
mass_dalton
84648
uniprot
proteins
mutagenesis
MUTAGEN 661..662; /note="EE->AA: Abrogates interaction with AKTIP, VPS16, VPS18, VPS39 and VPS41, AP4M1, FHIP1B, decreases interaction with HOOK2 but does not affect interaction with HOOK3; when associated with 669-A-A-670."; /evidence="ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997"; MUTAGEN 669..670; /note="WY->AA: Abrogates interaction with AKTIP, VPS16, VPS18, VPS39 and VPS41, AP4M1, FHIP1B, decreases interaction with HOOK2 but does not affect interaction with HOOK3; when associated with 661-A-A-662."; /evidence="ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997
uniprot
proteins
protein_family
Hook family
uniprot
proteins
pubmed
11238449
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15471887
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18799622
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26528954
uniprot
proteins
pubmed
32073997
uniprot
proteins
pubmed
9927460
uniprot
proteins
sequence_length
728
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15471887}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11238449}. Note=Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosomes, or mitochondria (By similarity). Often found in close association with microtubules (By similarity). Does not associate with the Golgi complex. During spermiogenesis, it localizes to the manchette in spermatids from steps 8-10. It is also present between the microtubule manchette and the nucleus. During manchette elongation, it is preferentially localized to the nuclear ring of the manchette, whereas the strong localization to the manchette decreases. In more mature spermatids, while the manchette migrates posteriorly, it localizes to punctuates spots. At later stages of spermatid differentiation, the punctuate expression pattern is found at both the attachment site and the proximal end of the elongated manchette. In contrast, it is not present in mature spermatozoa (By similarity). {ECO:0000250|UniProtKB:Q8BIL5}.
uniprot
proteins