Sh2d3c
entrez
27387
canonical
uniprot
Q9QZS8
canonical
ensembl
ENSMUSG00000059013
resolver
ensp
ENSMUSP00000073866
resolver
ensp
ENSMUSP00000108868
resolver
ensp
ENSMUSP00000230991
resolver
genesymbol
Sh2d3c
resolver
genesymbol_syn
Chat
resolver
genesymbol_syn
Shep1
resolver
uniprot
A2AK84
resolver
uniprot
Q9JME1
resolver
uniprot_entry
SH2D3_MOUSE
resolver
uniprot_sec
A2AK84
resolver
uniprot_sec
Q9JME1
resolver
amino_acid_sequence
MTEMPKKTGRKFKFFKFKGLGSLSNLPRSFSLRRSSASASIRSCPEPDTFEATQDDMVTLPKSPPAYARSSDMYSHMGTMPRPNIKKAQKQQAVQKAQEVSRESHLVSRRLPEPPDLEAAKEAGEGTEALLEDTAPSAVEVDPMRELEDLTVDTEKEQVPGDVSPERTAAELEAAGDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWHNQALHFKINKVVVKAGESYTHIRYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLSQGSSKTASPASPSGSKGSHMKRRSITMTDGLTTDKVTRSDGCPNSTSLPHPRDSIRNCALSMDQIPDLHSPLSPISESPSSPAYSTVTRVHAPSATPSTSAQPASPVARRSSEPQLCPGNTPKPPGESDRAPHASPSHTLCKASPSPSLSSYSDPDSGHYCQLQPPVRGSREQAAGETPRKARGSGERQKELLENGVSDGEWGKTFTVPVVEATSSFNLATFQSQLIPKENRPLEVALLRKVKELLSEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALEMAQISRLEQTWMTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPFITLLECDSAPAEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGANSSQAWRYEKFDKVLTALSHKLEPAIRSSEL
uniprot
proteins
function
FUNCTION: Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:20505138, PubMed:20881139, PubMed:20956287). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (By similarity). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (PubMed:20505138, PubMed:20956287). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (PubMed:20505138). Plays a role in CXCL13-induced chemotaxis of B-cells (PubMed:20505138, PubMed:20956287). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (PubMed:20881139). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (PubMed:20881139). {ECO:0000250|UniProtKB:Q8N5H7, ECO:0000269|PubMed:20505138, ECO:0000269|PubMed:20881139, ECO:0000269|PubMed:20956287}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (PubMed:17174122). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (PubMed:17174122). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (PubMed:17174122). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (PubMed:12486027). {ECO:0000269|PubMed:12486027, ECO:0000269|PubMed:17174122}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000269|PubMed:10692442}.
uniprot
proteins
mass_dalton
94323
uniprot
proteins
mutagenesis
MUTAGEN 787; /note="Y->E: Abolishes interaction with NEDD9. Abolishes interaction with BCAR1. Abolishes phosphorylation of NEDD9. Abolishes promotion of migration and adhesion in T cells."; /evidence="ECO:0000269|PubMed:17174122, ECO:0000269|PubMed:20956287"; MUTAGEN 787; /note="Y->E: Disrupts binding to BCAR1 and inhibits EGF-induced tyrosine phosphorylation."; /evidence="ECO:0000269|PubMed:15272013
uniprot
proteins
post_translational_modification
PTM: [Isoform 1]: Phosphorylated by MAPK/ERK upon T-cell receptor stimulation in T-cells. {ECO:0000269|PubMed:12486027}.
uniprot
proteins
pubmed
10542222
uniprot
proteins
pubmed
10692442
uniprot
proteins
pubmed
12486027
uniprot
proteins
pubmed
15272013
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17174122
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20505138
uniprot
proteins
pubmed
20881139
uniprot
proteins
pubmed
20956287
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
854
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10692442, ECO:0000269|PubMed:17174122, ECO:0000269|PubMed:20956287}. Cell membrane {ECO:0000269|PubMed:10692442}; Peripheral membrane protein {ECO:0000269|PubMed:10692442}. Cell projection, axon {ECO:0000269|PubMed:20881139}. Cell projection, ruffle membrane {ECO:0000269|PubMed:10692442}. Note=Associated with the membrane when EGF-stimulated (PubMed:10692442). Expressed at the cortical actin ring in B cells (PubMed:20956287). {ECO:0000269|PubMed:10692442, ECO:0000269|PubMed:20956287}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:17174122}; Peripheral membrane protein {ECO:0000269|PubMed:17174122}.
uniprot
proteins