Ripor2
entrez
306934
canonical
uniprot
Q7TP54
canonical
ensembl
ENSRNOG00000018804
resolver
ensp
ENSRNOP00000048390
resolver
ensp
ENSRNOP00000077001
resolver
ensp
ENSRNOP00000082516
resolver
ensp
ENSRNOP00000083444
resolver
ensp
ENSRNOP00000096012
resolver
ensp
ENSRNOP00000096913
resolver
enst
ENSRNOT00000048298
resolver
enst
ENSRNOT00000101796
resolver
enst
ENSRNOT00000102510
resolver
enst
ENSRNOT00000110402
resolver
enst
ENSRNOT00000117790
resolver
enst
ENSRNOT00000117811
resolver
genesymbol
Ripor2
resolver
genesymbol_syn
Fam65b
resolver
uniprot
A0A8I5Y5T3
resolver
uniprot
A0A8I5ZX07
resolver
uniprot
A0A8I6AP27
resolver
uniprot
A0A8I6AQC8
resolver
uniprot_entry
A0A8I5Y5T3_RAT
resolver
uniprot_entry
A0A8I5ZX07_RAT
resolver
uniprot_entry
A0A8I6AP27_RAT
resolver
uniprot_entry
A0A8I6AQC8_RAT
resolver
uniprot_entry
RIPR2_RAT
resolver
amino_acid_sequence
MQHCLEQSDITQYQQYYSSWCDARALGPRLSPVALSLLVGRNEHRLSAEPEVHRSQGRCVGVEVPREDINYLSTTCKPEIKSRNLKEDSEDQGRLPTRLPEIMLVGSQSFSPGGPNGIIRSQSFAGFSGLQERRSRQVLGVSPGITRAPSKDVYCKPGYACRVEFLLCKAFSKQTCNSFIENASALKKPQAKLKKMHNLGHKNTNTPKEPQPKRVEEVYRALKNGLDEYLEFHQTELDKLTAQLKDMKRNSRLGVLYDLDKGVLYDLDKVDELYEAYCIQRRLQDGASKMKQAFATSPASKAARESLSEINRSYKEYTENMCTIEAELESLLGEFSIKMKGLAGFARLCPGDQYESMDGPNPYQRQQGEVYFSLLATRRIGDGSCLSKGARIFMKYGRQRWKLKGKIEVNGKQSWDGEETVFLPLIVGFISIKVTELKGLATHILVGSVTCETKELFAARPQVVAVDINDLGTIKLNLEITWYPFDVEDTTPSSGPGNKTAALQRRMSMYSQGTPETPTFKDQSFFSNLPDDIFESGNAAEEKRPLSLSFSDLQDGDCVFTSSSTTSPSSSHSAHPEITITPAELTHSSLSSQNEGTEDSSSASSRNSLGEDHEPKSHSKSDTVEPKKPSVDARSGTESLFLENSVAEALLQESDEASELKPVELDTFEGNITKQLVKRLTSAEGPITTNKLFFEGSVGSESEAGRSFLDGSLEDAFNGLFLALDPHKEQYKEFQDLNQEVTHLDDVLKCKPAGSRSRSSSLSLTVESALESFDFLNTSDFDEEEEDGDEVCHVGGGADSVFSDTETEKSGSVHPEARGHLSEALTEDTGVGTSVAGSPLPLTTGNESLDITIVKHLQYCTQLVQQIVFSSKTPFVARSLLEKLSRQVLVLQKLAAVSDENLGNITSVVEAIPEFHKKPSLLSFWTKCCSPSGVYHSSAAHLIKQLEASFARNINKDYPGLAEPVFRTLVSQILDRAEPLLCSGLSSEVITVFQYYSFLTSHGVSDLETHLGQLARQVAMVQTLQSLRDEKLLQTMSDLAPSNLPAQQEVLRTLALLLTKDDNEVSEAVTLYLAAASKNEHFREKALLYYCEALTKTNLQLQKAACLALKSLEATESIKMLVTLCQSDTEEIRTVASETLLSLAPYSGSAMTSQIRQNYSTEVEAAVNRLVNLHLRASYTYLSLGFFFDPDDVALEGNERGGRALFQDVQKPSQDEWGKTLEAMEAALALEKNLNQALLDLHALGSARTDPHLCDFLESHFLDKEVKLIKKMGNHLTNLRRVAGPQPAQTGVAQASLGEYLFERLTLKHD
uniprot
proteins
function
FUNCTION: Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (By similarity). Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (By similarity). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function. Required for normal hearing (By similarity). {ECO:0000250|UniProtKB:Q80U16, ECO:0000250|UniProtKB:Q9Y4F9}.
uniprot
proteins
mass_dalton
144709
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Chemokine-induced phosphorylation in neutrophils occurs in a PKC- and AKT-dependent manner, resulting in RIPOR2 interaction with YWHAB and stabilization. Phosphorylated by PKCA, AKT1 and MAPKAPK1A; in vitro. {ECO:0000250|UniProtKB:Q9Y4F9}.
uniprot
proteins
protein_family
RIPOR family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24958875
uniprot
proteins
sequence_length
1310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y4F9}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9Y4F9}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9Y4F9}. Apical cell membrane {ECO:0000269|PubMed:24958875}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q80U16}. Cell projection, stereocilium membrane {ECO:0000269|PubMed:24958875}. Note=Localized in the cytoplasm in cells undergoing mitosis (By similarity). Colocalized with F-actin. Accumulates at the leading edge of polarized neutrophils in a chemokine-dependent manner. Localized with RHOC within the basal domain of hair cell stereocilia, near the taper region. Detected in punctate pattern forming a circumferential ring at the stereocilia base (By similarity). Localized to the apical stereocilia of inner and outer hair cells (PubMed:24958875). {ECO:0000250|UniProtKB:Q80U16, ECO:0000250|UniProtKB:Q9Y4F9, ECO:0000269|PubMed:24958875}.
uniprot
proteins