Nin
entrez
18080
canonical
uniprot
Q61043
canonical
ensembl
ENSMUSG00000021068
resolver
ensp
ENSMUSP00000021468
resolver
ensp
ENSMUSP00000082422
resolver
ensp
ENSMUSP00000129648
resolver
ensp
ENSMUSP00000206868
resolver
ensp
ENSMUSP00000206870
resolver
ensp
ENSMUSP00000206872
resolver
ensp
ENSMUSP00000206876
resolver
genesymbol
Nin
resolver
genesymbol_syn
Kiaa1565
resolver
uniprot
A0A1Y7VJL5
resolver
uniprot
B2RQ73
resolver
uniprot
B7ZMZ9
resolver
uniprot
E9Q488
resolver
uniprot
E9Q4S3
resolver
uniprot
Q3UR16
resolver
uniprot
Q674R4
resolver
uniprot
Q6ZPM7
resolver
uniprot_entry
NIN_MOUSE
resolver
uniprot_entry
Q3UR16_MOUSE
resolver
uniprot_sec
A0A1Y7VJL5
resolver
uniprot_sec
B2RQ73
resolver
uniprot_sec
B7ZMZ9
resolver
uniprot_sec
E9Q488
resolver
uniprot_sec
E9Q4S3
resolver
uniprot_sec
Q674R4
resolver
uniprot_sec
Q6ZPM7
resolver
amino_acid_sequence
MDEVEEDQHEARLKELFDSFDTLGTGSLGQEELTDLCHVLCLEDVGPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSSEEHFEESDCSPEAQPKYVRGGKRYGRRSLPEFQESGEEIEEVTVLEPLEEEARSSPIPAGDCGEHWKTQRSEEYEAEGQLRFWNPDDLNASHGGSCPPPDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGAMLEEVFLSLDPDGTMSVEDFFYGLFKTGKSLTPSASTPYRQLKRHLSMQSFDESGRRTATSSAMTSTIGFRVFSCLDDGMGQASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNGIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRQEREQMLQQVGKQRVELEQEIQKAKTEENYIRDRLALSLKENNRLETELLENAEKLAEYESLTQKLQRSLENVLAEKFGDLDPSSAEFFLQEERLAQMRNEYEQQCRLLQDQVDELQSELEEYQAQGRVLRLPLKNSLSEELDGHSGGIEPDQGPGSEECNPLNMSIEAELVIEQMKEQHHRDLCHLRLELEDKVRHYEKQLDDTRVASEQEQAAMKQKYEQGVHTLEKRVSELRSEIADLEGQAAVLREAHHKASCRHEEEKRQLQMAFDEEKAQLQEELRQEHERELQARLQQAAESFRQEREGLAQAAWTEEKVRGLEQSYQEQLLSLEEKHALEKEELREELSEHHRRELQEGREEMETECNRRVSQIEAQCQADCEKVTEHCEQTLQSLEVRHRQELRDLLDQHLEERSQWEFEKDELTQECTDAQEQLKEALQRERATAAAMKQEQEILERTYKDRLNILSTERKQLLQDLKDLQNASESQHGLLSGQILELKRSQERELRDQGQALCQTGVSEQLASQQLERLRVEHEQERREMTGKLAALESAHRASLERADQEKAEMSTEICRLQNTVKDMQQAASLLMLQGGCQATAGEEAEGDGAMSLLQQGEQLLEENGDVLISLQRAHEHAVKENAKMATEISRLQQRLKKLEPGSVISSCLEEGTSEISGSSREQVEPIMKQGPATKHFLSDLGDHEARDLASTGTSSVQRQECKTEASEASLDCFSELENSEDTRTESWDLKSQISQLREQLTVLRADCDRASERKQDLLFDISVLKKKLKMLERLPEASSRYKVLYEDAARENSCLQEELRLVETRYEESLDSNKELTAEVYRLQDEMKKMEEVMETFLSLEKSYDEVKVENEELRALVLRLQGKMEKVLGRAALQGDSYALWEAPSENLEVASDEKMLELRQTPKECTPKVVSMHHIIEECTQETQCCEQGSTKLLARIKAHEIAWFHRAIKTHPEKPSAQNRVIPEGSAALLGLQDKHLQQEATIAELELEKQKLQELTRNLRERVTALVRQKDAPSQGQKEEELKAMMQDLQITCGEMQRKVELLRYESEKLQEENSILRNEITTLNEEDSISNLKLEELNGSQEELWQKIETIEQEKASIQTMVEKLKKQVSDLKIKNQQLDSENIELSQKNSQNKEELKTLNQRLAEMLCQREEPGACTSEKWEQENASLKEELDHYKVQTSTLVSSLEAELSEVKLQTHVMEQENLLLKDELERLKQLHRCPDLSDFQQKMSSILSYNEKLLKEKEVLSEELKSCADKLAESSLLEHRIATMKQEQTAWEEQSESLKSQLAVSQAKVQNLEDVLQNVNLQMAEIESDLQVTRQEKEALKQEVMSLHRQLQNAIDKDWVSETAPHLSGLRGQQRRLSWDKLDHLMNEEPQLLCQESKRLQTVVQNTQADLTHSREKVRQLESNLLPTKHQKQLNQPCTVKSTEQEKLTLKRECEQSQKEQSPTSRKVGQMGSLERGLETIHLENEGLKKKQMQPLRSTVTRSPSSHWDLQLLQQQACPMVPREQFLQLQQQLLQAEKRSQHLQEELENRTSETNTPQGNQEHLVNLMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKTDAVVKDLYVENAQLLKALEMTEQRQKTAEKRNFLLEEKIASLSTIVRNLAPAPLTSMPPLRS
uniprot
proteins
function
FUNCTION: Centrosomal protein required for the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:10934040, PubMed:15784680). May also act as a centrosome maturation factor (By similarity). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15784680). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (By similarity). Required for centriole organization and microtubule anchoring at the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q8N4C6, ECO:0000269|PubMed:10934040, ECO:0000269|PubMed:15784680}.
uniprot
proteins
mass_dalton
243718
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by AURKA/Aurora kinase A and PKA kinases but not CK2 or AURKB/Aurora kinase B.
uniprot
proteins
pubmed
10934040
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15784680
uniprot
proteins
pubmed
17227889
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27565344
uniprot
proteins
pubmed
8834802
uniprot
proteins
sequence_length
2113
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27565344, ECO:0000269|PubMed:8834802}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15784680, ECO:0000269|PubMed:17227889}. Cell junction, desmosome {ECO:0000269|PubMed:17227889}. Note=Component of the core centrosome. Arranged in a tubular conformation with an open and a closed end within the centrosome. In the mother centrosome, it localizes at both ends of the centrosome tube, including the site of centrosome duplication, while in the daughter centrosome it is present only at the closed end. Requires PCM1 for centrosome localization. Localizes to the subdistal appendage region of the centriole in a DCTN1-dependent manner. Localizes to desmosome cell-cell junctions in terminally differentiated epidermal and keratinocyte cells (PubMed:17227889). {ECO:0000250|UniProtKB:Q8N4C6, ECO:0000269|PubMed:17227889}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:27565344}. Note=Seems to have a dominant-negative effect on localization of other isoforms, promoting their dissociation from the centrosome. {ECO:0000269|PubMed:27565344}.
uniprot
proteins