Clic1
entrez
114584
canonical
uniprot
Q9Z1Q5
canonical
ensembl
ENSMUSG00000007041
resolver
ensp
ENSMUSP00000007257
resolver
enst
ENSMUST00000007257
resolver
genesymbol
Clic1
resolver
uniprot
Q542F1
resolver
uniprot_entry
CLIC1_MOUSE
resolver
uniprot_entry
Q542F1_MOUSE
resolver
amino_acid_sequence
MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKIEEFLEAMLCPPRYPKLAALNPESNTSGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGISQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVARALK
uniprot
proteins
ec_number
1.8.-.-
uniprot
proteins
ec_number
1.8.5.1
uniprot
proteins
function
FUNCTION: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (By similarity). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle (By similarity). {ECO:0000250|UniProtKB:O00299}.
uniprot
proteins
mass_dalton
27013
uniprot
proteins
protein_family
Chloride channel CLIC family
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O00299}. Nucleus membrane {ECO:0000250|UniProtKB:O00299}; Single-pass membrane protein {ECO:0000250|UniProtKB:O00299}. Cytoplasm {ECO:0000250|UniProtKB:O00299}. Cell membrane {ECO:0000250|UniProtKB:O00299}; Single-pass membrane protein {ECO:0000250|UniProtKB:O00299}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q6MG61}. Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). Might not be present in the nucleus of cardiac cells (By similarity). {ECO:0000250|UniProtKB:O00299, ECO:0000250|UniProtKB:Q6MG61}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical; Note=After insertion into the membrane"; /evidence="ECO:0000255
uniprot
proteins