NECAB2
entrez
54550
canonical
uniprot
Q7Z6G3
canonical
ensembl
ENSG00000103154
resolver
ensp
ENSP00000307449
resolver
ensp
ENSP00000457354
resolver
genesymbol
NECAB2
resolver
genesymbol_syn
EFCBP2
resolver
hgnc
HGNC:23746
resolver
uniprot
A2RRG3
resolver
uniprot
H3BTW2
resolver
uniprot
O75547
resolver
uniprot
Q6ZSK0
resolver
uniprot_entry
NECA2_HUMAN
resolver
uniprot_sec
A2RRG3
resolver
uniprot_sec
H3BTW2
resolver
uniprot_sec
O75547
resolver
uniprot_sec
Q6ZSK0
resolver
amino_acid_sequence
MCERAARLCRAGAHRLLREPPQQGRALGGLLRWVGARMGEPRESLAPAAPADPGPASPRGGTAVILDIFRRADKNDDGKLSLEEFQLFFADGVLNEKELEDLFHTIDSDNTNHVDTKELCDYFVDHMGDYEDVLASLETLNHSVLKAMGYTKKVYEGGSNVDQFVTRFLLKETANQIQSLLSSVESAVEAIEEQTSQLRQNHIKPSHSAAQTWCGSPTPASAPNHKLMAMEQGKTLPSATEDAKEEGLEAQISRLAELIGRLESKALWFDLQQRLSDEDGTNMHLQLVRQEMAVCPEQLSEFLDSLRQYLRGTTGVRNCFHITAVRLSDGFTFVIYEFWETEEAWKRHLQSPLCKAFRHVKVDTLSQPEALSRILVPAAWCTVGRD
uniprot
proteins
function
FUNCTION: May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. {ECO:0000305|PubMed:17689978, ECO:0000305|PubMed:19694902}.
uniprot
proteins
mass_dalton
43194
uniprot
proteins
pubmed
12044471
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17689978
uniprot
proteins
pubmed
19694902
uniprot
proteins
pubmed
26843217
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:F1LQY6, ECO:0000250|UniProtKB:Q91ZP9}. Cell projection, dendrite {ECO:0000250|UniProtKB:F1LQY6}. Cell projection, axon {ECO:0000250|UniProtKB:F1LQY6}. Cell membrane {ECO:0000269|PubMed:17689978, ECO:0000269|PubMed:19694902}. Note=Colocalizes with ADORA2A and/or mGluR5/GRM5 at the plasma membrane (PubMed:17689978, PubMed:19694902). Found in neuronal somata (PubMed:26843217). Detected in the cytoplasm of striatal neurons, at postsynaptic sites, filling dendritic shafts and spines, and at presynaptic sites, filling axon terminals (By similarity). {ECO:0000250|UniProtKB:F1LQY6, ECO:0000269|PubMed:17689978, ECO:0000269|PubMed:19694902, ECO:0000269|PubMed:26843217}.
uniprot
proteins