STMN1
entrez
3925
canonical
uniprot
P16949
canonical
ensembl
ENSG00000117632
resolver
ensp
ENSP00000350531
resolver
ensp
ENSP00000382633
resolver
ensp
ENSP00000387858
resolver
ensp
ENSP00000410452
resolver
genesymbol
STMN1
resolver
genesymbol_syn
C1orf215
resolver
genesymbol_syn
LAP18
resolver
genesymbol_syn
OP18
resolver
hgnc
HGNC:6510
resolver
uniprot
A0A140VJW2
resolver
uniprot
A2A2D1
resolver
uniprot
B2R4E7
resolver
uniprot
B7Z8N4
resolver
uniprot
D3DPJ5
resolver
uniprot_entry
A0A140VJW2_HUMAN
resolver
uniprot_entry
STMN1_HUMAN
resolver
uniprot_sec
A2A2D1
resolver
uniprot_sec
B2R4E7
resolver
uniprot_sec
B7Z8N4
resolver
uniprot_sec
D3DPJ5
resolver
amino_acid_sequence
MASSDIQVKELEKRASGQAFELILSPRSKESVPEFPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHIEEVRKNKESKDPADETEAD
uniprot
proteins
function
FUNCTION: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
17303
uniprot
proteins
post_translational_modification
PTM: Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. {ECO:0000250, ECO:0000269|PubMed:1737801, ECO:0000269|PubMed:8125092, ECO:0000269|PubMed:8245003, ECO:0000269|PubMed:8325880}.
uniprot
proteins
protein_family
Stathmin family
uniprot
proteins
pubmed
10675326
uniprot
proteins
pubmed
10702243
uniprot
proteins
pubmed
11415983
uniprot
proteins
pubmed
12676564
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16548883
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
1737801
uniprot
proteins
pubmed
17693683
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
1917919
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2358074
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2546936
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2760073
uniprot
proteins
pubmed
8125092
uniprot
proteins
pubmed
8245003
uniprot
proteins
pubmed
8325880
uniprot
proteins
pubmed
8906359
uniprot
proteins
sequence_length
149
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
uniprot
proteins