Map3k8
entrez
26410
canonical
uniprot
Q07174
canonical
ensembl
ENSMUSG00000024235
resolver
ensp
ENSMUSP00000025078
resolver
enst
ENSMUST00000025078
resolver
genesymbol
Map3k8
resolver
genesymbol_syn
Cot
resolver
genesymbol_syn
Tpl2
resolver
uniprot
Q3UEB8
resolver
uniprot_entry
M3K8_MOUSE
resolver
uniprot_entry
Q3UEB8_MOUSE
resolver
amino_acid_sequence
MEYMSTGSDEKEEIDLLIKHLNVSEVIDIMENLYASEEPGVYEPSLMTMYPDSNQNEERSESLLRSGQEVPWLSSVRYGTVEDLLAFANHVSNMTKHFYGRRPQECGILLNMVISPQNGRYQIDSDVLLVPWKLTYRNIGSGFVPRGAFGKVYLAQDMKTKKRMACKLIPIDQFKPSDVEIQACFRHENIAELYGAVLWGDTVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHILKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVKMTEDVYLPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIAGDCSPGMRELIEAALERNPNHRPKAADLLKHEALNPPREDQPRCQSLDSALFERKRLLSRKELQLPENIADSSCTGSTEESEVLRRQRSLYIDLGALAGYFNIVRGPPTLEYG
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. {ECO:0000269|PubMed:11163183, ECO:0000269|PubMed:12667451, ECO:0000269|PubMed:12881420, ECO:0000269|PubMed:15833743, ECO:0000269|PubMed:19001140, ECO:0000269|PubMed:19808894, ECO:0000269|PubMed:23842752}.
uniprot
proteins
mass_dalton
52942
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
11163183
uniprot
proteins
pubmed
12667451
uniprot
proteins
pubmed
12881420
uniprot
proteins
pubmed
15833743
uniprot
proteins
pubmed
19001140
uniprot
proteins
pubmed
19808894
uniprot
proteins
pubmed
23842752
uniprot
proteins
pubmed
8320169
uniprot
proteins
sequence_length
467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins