Nsmf
entrez
117536
canonical
uniprot
Q9EPI6
canonical
ensembl
ENSRNOG00000008810
resolver
ensp
ENSRNOP00000012129
resolver
ensp
ENSRNOP00000040572
resolver
ensp
ENSRNOP00000044714
resolver
ensp
ENSRNOP00000058016
resolver
enst
ENSRNOT00000012129
resolver
enst
ENSRNOT00000042100
resolver
enst
ENSRNOT00000048353
resolver
enst
ENSRNOT00000061303
resolver
genesymbol
Nsmf
resolver
genesymbol_syn
Jac
resolver
genesymbol_syn
Nelf
resolver
uniprot
A0A140TAI4
resolver
uniprot
D3ZVR5
resolver
uniprot
D4A9M2
resolver
uniprot
F1LLY3
resolver
uniprot
Q5PPF6
resolver
uniprot
Q7TSC6
resolver
uniprot
Q7TSC8
resolver
uniprot
Q9EPI4
resolver
uniprot
Q9EPI5
resolver
uniprot_entry
A0A140TAI4_RAT
resolver
uniprot_entry
D3ZVR5_RAT
resolver
uniprot_entry
D4A9M2_RAT
resolver
uniprot_entry
F1LLY3_RAT
resolver
uniprot_entry
NSMF_RAT
resolver
uniprot_sec
Q5PPF6
resolver
uniprot_sec
Q7TSC6
resolver
uniprot_sec
Q7TSC8
resolver
uniprot_sec
Q9EPI4
resolver
uniprot_sec
Q9EPI5
resolver
amino_acid_sequence
MGAAASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGADHLLADAYSGHEGSPEMQPAPHNKRRLSLVSNGRYEGSISDEAVSGKTATEGPQPRVYTISREPALLPGSEAEAIELAVVKGRRQRERHPHHHSQPLRASPGSSREDISRPCQSWAGSRQGSKECPGCAKLVPGPSPRAFGLEQPPLPEASGRHKKLERMYSVDGVSDDVPIRTWFPKENPFSFQTATTTMQAISVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLDEACEDLDWDTEKGLEATACDTEGFLPPKVMLISSKVPKAEYIPTIIRRDDPSIIPILYDHEHATFEDILEEIEKKLNIYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHIMGCYILGNPNGEKLFQNLRTLMTPYKVTFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFDDVL
uniprot
proteins
function
FUNCTION: Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. {ECO:0000269|PubMed:18303947}.
uniprot
proteins
mass_dalton
60282
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Exclusive nuclear localization. Shows a reduction in synaptic contacts and dendritic processes."; /evidence="ECO:0000269|PubMed:18303947"; MUTAGEN 241; /note="F->E: Loss of CABP1 binding."; /evidence="ECO:0000269|PubMed:18303947"; MUTAGEN 247..252; /note="Missing: Extranuclear localization and reduced CABP1 and KPNA1 binding. Shows a reduction in synaptic contacts and dendritic processes."; /evidence="ECO:0000269|PubMed:18303947"; MUTAGEN 260..261; /note="IQ->GG: No effect on CABP1 binding."; /evidence="ECO:0000269|PubMed:18303947
uniprot
proteins
post_translational_modification
PTM: Proteolytically processed after NMDA receptor activation. Cleaved in a calcium-dependent and calpain-sensitive manner. Calpain cleavage is essential for the translocation process from dendrites to the nucleus. {ECO:0000269|PubMed:19608740}.
uniprot
proteins
protein_family
NSMF family
uniprot
proteins
pubmed
15018815
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18303947
uniprot
proteins
pubmed
19608740
uniprot
proteins
pubmed
21364755
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
532
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Nucleus envelope. Nucleus membrane. Nucleus matrix. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Synapse. Synapse, synaptosome. Postsynaptic density. Membrane. Note=Found on the outside of the luteinizing-hormone-releasing hormone (LHRH) cell membrane and axons projecting from the olfactory pit and epithelium (By similarity). Associates with transcriptionally active chromatin regions. Detected at the nuclear membranes of CA1 neurons. Cortical cytoskeleton. Localized in proximal apical dendrites. Colocalizes with CABP1 in dendrites and dendritic spines. Myristoylation is a prerequisite for extranuclear localization. Translocates from dendrites to the nucleus during NMDA receptor-dependent long-term potentiation (LTP) induction of synaptic transmission at Schaffer collateral/CA1 synapses of hippocampal primary neurons and in an importin-dependent manner. {ECO:0000250}.
uniprot
proteins