PRRT1
entrez
80863
canonical
uniprot
Q99946
canonical
ensembl
ENSG00000204314
resolver
ensembl
ENSG00000206331
resolver
ensembl
ENSG00000225141
resolver
ensembl
ENSG00000227122
resolver
ensembl
ENSG00000229071
resolver
ensembl
ENSG00000229488
resolver
ensembl
ENSG00000235956
resolver
ensembl
ENSG00000238056
resolver
ensp
ENSP00000211413
resolver
genesymbol
PRRT1
resolver
genesymbol_syn
C6orf31
resolver
genesymbol_syn
NG5
resolver
hgnc
HGNC:13943
resolver
uniprot
A6ND08
resolver
uniprot
A6ND40
resolver
uniprot
B0S869
resolver
uniprot
Q5SSW4
resolver
uniprot
Q5SSX7
resolver
uniprot
Q5STI1
resolver
uniprot
Q96DW3
resolver
uniprot
Q96NQ8
resolver
uniprot_entry
PRRT1_HUMAN
resolver
uniprot_sec
A6ND08
resolver
uniprot_sec
A6ND40
resolver
uniprot_sec
B0S869
resolver
uniprot_sec
Q5SSW4
resolver
uniprot_sec
Q5SSX7
resolver
uniprot_sec
Q5STI1
resolver
uniprot_sec
Q96DW3
resolver
uniprot_sec
Q96NQ8
resolver
amino_acid_sequence
MSSEKSGLPDSVPHTSPPPYNAPQPPAEPPAPPPQAAPSSHHHHHHHYHQSGTATLPRLGAGGLASSAATAQRGPSSSATLPRPPHHAPPGPAAGAPPPGCATLPRMPPDPYLQETRFEGPLPPPPPAAAAPPPPAPAQTAQAPGFVVPTHAGTVGTLPLGGYVAPGYPLQLQPCTAYVPVYPVGTPYAGGTPGGTGVTSTLPPPPQGPGLALLEPRRPPHDYMPIAVLTTICCFWPTGIIAIFKAVQVRTALARGDMVSAEIASREARNFSFISLAVGIAAMVLCTILTVVIIIAAQHHENYWDP
uniprot
proteins
function
FUNCTION: Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function. Regulates basal AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses. Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression. {ECO:0000250|UniProtKB:O35449}.
uniprot
proteins
mass_dalton
31430
uniprot
proteins
protein_family
CD225/Dispanin family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
22363774
uniprot
proteins
sequence_length
306
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6MG82}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q6MG82}. Synapse {ECO:0000250|UniProtKB:Q6MG82}.
uniprot
proteins
transmembrane_region
TRANSMEM 224..244; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins