Meis2
entrez
17536
canonical
uniprot
P97367
canonical
ensembl
ENSMUSG00000027210
resolver
ensp
ENSMUSP00000028639
resolver
ensp
ENSMUSP00000073898
resolver
ensp
ENSMUSP00000099597
resolver
ensp
ENSMUSP00000106531
resolver
ensp
ENSMUSP00000106532
resolver
ensp
ENSMUSP00000106533
resolver
ensp
ENSMUSP00000216307
resolver
ensp
ENSMUSP00000216309
resolver
enst
ENSMUST00000074285
resolver
enst
ENSMUST00000110906
resolver
genesymbol
Meis2
resolver
genesymbol_syn
Mrg1
resolver
genesymbol_syn
Stra10
resolver
uniprot
A0A0A7EPH8
resolver
uniprot
B1AWK4
resolver
uniprot
F6Z475
resolver
uniprot
O35676
resolver
uniprot
O35677
resolver
uniprot
P97403
resolver
uniprot
P97404
resolver
uniprot
Q3TY73
resolver
uniprot
Q3TYM2
resolver
uniprot
Q3UJ35
resolver
uniprot
Q6GU28
resolver
uniprot_entry
A0A0A7EPH8_MOUSE
resolver
uniprot_entry
B1AWK4_MOUSE
resolver
uniprot_entry
F6Z475_MOUSE
resolver
uniprot_entry
MEIS2_MOUSE
resolver
uniprot_entry
Q3TY73_MOUSE
resolver
uniprot_entry
Q3TYM2_MOUSE
resolver
uniprot_entry
Q3UJ35_MOUSE
resolver
uniprot_entry
Q6GU28_MOUSE
resolver
uniprot_sec
O35676
resolver
uniprot_sec
O35677
resolver
uniprot_sec
P97403
resolver
uniprot_sec
P97404
resolver
amino_acid_sequence
MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMGMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHPHHPAMVMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ
uniprot
proteins
function
FUNCTION: Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoforms Meis2B and Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription. {ECO:0000269|PubMed:11279116, ECO:0000269|PubMed:11438208, ECO:0000269|PubMed:17178831}.
uniprot
proteins
mass_dalton
51728
uniprot
proteins
protein_family
TALE/MEIS homeobox family
uniprot
proteins
pubmed
10842069
uniprot
proteins
pubmed
11279116
uniprot
proteins
pubmed
11438208
uniprot
proteins
pubmed
15617687
uniprot
proteins
pubmed
17178831
uniprot
proteins
pubmed
21059917
uniprot
proteins
pubmed
8950991
uniprot
proteins
pubmed
9049632
uniprot
proteins
pubmed
9337137
uniprot
proteins
pubmed
9710595
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:9710595}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21059917}.
uniprot
proteins