HTR1B
entrez
3351
canonical
uniprot
P28222
canonical
ensembl
ENSG00000135312
resolver
ensp
ENSP00000358963
resolver
enst
ENST00000369947
resolver
genesymbol
HTR1B
resolver
genesymbol_syn
HTR1DB
resolver
hgnc
HGNC:5287
resolver
uniprot
A8K215
resolver
uniprot
Q4VAY7
resolver
uniprot
X5D7I5
resolver
uniprot_entry
5HT1B_HUMAN
resolver
uniprot_entry
A8K215_HUMAN
resolver
uniprot_entry
X5D7I5_HUMAN
resolver
uniprot_sec
Q4VAY7
resolver
amino_acid_sequence
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:10452531, PubMed:1315531, PubMed:1328844, PubMed:1348246, PubMed:1351684, PubMed:1559993, PubMed:1565658, PubMed:1610347, PubMed:23519210, PubMed:23519215, PubMed:29925951, PubMed:8218242). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD) (PubMed:23519210, PubMed:23519215, PubMed:29925951). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:10452531, PubMed:1315531, PubMed:1328844, PubMed:1348246, PubMed:1351684, PubMed:1559993, PubMed:1565658, PubMed:1610347, PubMed:23519210, PubMed:23519215, PubMed:29925951, PubMed:8218242). HTR1B is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed:29925951, PubMed:35610220). Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:29925951). Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior (PubMed:18476671, PubMed:20945968). Besides, plays a role in vasoconstriction of cerebral arteries (PubMed:15853772). {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:15853772, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:29925951, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:8218242, ECO:0000303|PubMed:18476671, ECO:0000303|PubMed:20945968}.
uniprot
proteins
mass_dalton
43568
uniprot
proteins
mutagenesis
MUTAGEN 126; /note="L->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 129; /note="D->A: Abolishes agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 130; /note="I->A: Abolishes agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 133; /note="C->A: Abolishes agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 134; /note="T->A: Slightly decreases agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 200; /note="V->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 201; /note="V->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 203; /note="T->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 209; /note="T->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 212; /note="S->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 216; /note="A->S: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 327; /note="W->A: Abolishes agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 330; /note="F->A: Abolishes agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 331; /note="F->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 334; /note="S->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 334; /note="S->E: Reduced G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35610220"; MUTAGEN 337; /note="M->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 351; /note="F->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 352; /note="D->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 355; /note="T->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 359; /note="Y->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation. {ECO:0000269|PubMed:8218242}.; PTM: Palmitoylated. {ECO:0000269|PubMed:8218242}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10452531
uniprot
proteins
pubmed
1315531
uniprot
proteins
pubmed
1328844
uniprot
proteins
pubmed
1348246
uniprot
proteins
pubmed
1351684
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15014171
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1559993
uniprot
proteins
pubmed
1565658
uniprot
proteins
pubmed
15853772
uniprot
proteins
pubmed
1610347
uniprot
proteins
pubmed
18476671
uniprot
proteins
pubmed
20945968
uniprot
proteins
pubmed
23519210
uniprot
proteins
pubmed
23519215
uniprot
proteins
pubmed
29925951
uniprot
proteins
pubmed
35610220
uniprot
proteins
pubmed
7802650
uniprot
proteins
pubmed
8218242
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215}; Multi-pass membrane protein {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..72; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79"; TRANSMEM 87..111; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79"; TRANSMEM 120..145; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79"; TRANSMEM 166..184; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79"; TRANSMEM 206..229; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79"; TRANSMEM 316..337; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79"; TRANSMEM 348..370; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79
uniprot
proteins