TPO
entrez
7173
canonical
uniprot
P07202
canonical
ensembl
ENSG00000115705
resolver
ensp
ENSP00000263886
resolver
ensp
ENSP00000318820
resolver
ensp
ENSP00000329869
resolver
ensp
ENSP00000371633
resolver
ensp
ENSP00000371636
resolver
ensp
ENSP00000405788
resolver
ensp
ENSP00000568293
resolver
genesymbol
TPO
resolver
hgnc
HGNC:12015
resolver
uniprot
P09934
resolver
uniprot
P09935
resolver
uniprot
Q502Y3
resolver
uniprot
Q6P534
resolver
uniprot
Q8IUL0
resolver
uniprot
Q8NF94
resolver
uniprot
Q8NF95
resolver
uniprot
Q8NF96
resolver
uniprot
Q8NF97
resolver
uniprot
Q8TCI9
resolver
uniprot_entry
PERT_HUMAN
resolver
uniprot_entry
Q502Y3_HUMAN
resolver
uniprot_entry
Q6P534_HUMAN
resolver
uniprot_sec
P09934
resolver
uniprot_sec
P09935
resolver
uniprot_sec
Q8IUL0
resolver
uniprot_sec
Q8NF94
resolver
uniprot_sec
Q8NF95
resolver
uniprot_sec
Q8NF96
resolver
uniprot_sec
Q8NF97
resolver
uniprot_sec
Q8TCI9
resolver
amino_acid_sequence
MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQAVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL
uniprot
proteins
disease_involvement
DISEASE: Note=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.; DISEASE: Thyroid dyshormonogenesis 2A (TDH2A) [MIM:274500]: A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. {ECO:0000269|PubMed:10084596, ECO:0000269|PubMed:10468986, ECO:0000269|PubMed:11061528, ECO:0000269|PubMed:11415848, ECO:0000269|PubMed:11874711, ECO:0000269|PubMed:11916616, ECO:0000269|PubMed:12213873, ECO:0000269|PubMed:12490071, ECO:0000269|PubMed:12843174, ECO:0000269|PubMed:12864797, ECO:0000269|PubMed:12938097, ECO:0000269|PubMed:16284446, ECO:0000269|PubMed:16684826, ECO:0000269|PubMed:27305979, ECO:0000269|PubMed:7550241, ECO:0000269|PubMed:9024270, ECO:0000269|PubMed:9924196}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.11.1.8
uniprot
proteins
function
FUNCTION: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). {ECO:0000250|UniProtKB:P09933}.
uniprot
proteins
mass_dalton
102963
uniprot
proteins
pathway_participation
PATHWAY: Hormone biosynthesis; thyroid hormone biosynthesis.
uniprot
proteins
post_translational_modification
PTM: Glycosylated.; PTM: Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.; PTM: Cleaved in its N-terminal part.
uniprot
proteins
protein_family
Peroxidase family
uniprot
proteins
protein_family
XPO subfamily
uniprot
proteins
pubmed
10084596
uniprot
proteins
pubmed
10468986
uniprot
proteins
pubmed
11061528
uniprot
proteins
pubmed
11415848
uniprot
proteins
pubmed
11874711
uniprot
proteins
pubmed
11916616
uniprot
proteins
pubmed
12213873
uniprot
proteins
pubmed
12454013
uniprot
proteins
pubmed
12490071
uniprot
proteins
pubmed
12843174
uniprot
proteins
pubmed
12864797
uniprot
proteins
pubmed
12938097
uniprot
proteins
pubmed
15561711
uniprot
proteins
pubmed
16284446
uniprot
proteins
pubmed
16684826
uniprot
proteins
pubmed
2308857
uniprot
proteins
pubmed
2383265
uniprot
proteins
pubmed
2548579
uniprot
proteins
pubmed
27305979
uniprot
proteins
pubmed
3453124
uniprot
proteins
pubmed
3475693
uniprot
proteins
pubmed
3654979
uniprot
proteins
pubmed
7550241
uniprot
proteins
pubmed
9024270
uniprot
proteins
pubmed
9924196
uniprot
proteins
sequence_length
933
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell surface.
uniprot
proteins
transmembrane_region
TRANSMEM 847..871; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins