LGR5
entrez
8549
canonical
uniprot
O75473
canonical
ensembl
ENSG00000139292
resolver
ensp
ENSP00000266674
resolver
ensp
ENSP00000441035
resolver
ensp
ENSP00000443033
resolver
genesymbol
GPR49
resolver
genesymbol
LGR5
resolver
genesymbol_syn
GPR49
resolver
genesymbol_syn
GPR67
resolver
genesymbol_syn
LGR5
resolver
hgnc
HGNC:4504
resolver
uniprot
A0A0A8K8C7
resolver
uniprot
D8MCT0
resolver
uniprot
Q4VAM0
resolver
uniprot
Q4VAM2
resolver
uniprot
Q9UP75
resolver
uniprot_entry
A0A0A8K8C7_HUMAN
resolver
uniprot_entry
LGR5_HUMAN
resolver
uniprot_sec
D8MCT0
resolver
uniprot_sec
Q4VAM0
resolver
uniprot_sec
Q4VAM2
resolver
uniprot_sec
Q9UP75
resolver
amino_acid_sequence
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYVWTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPSPAYPVTESCHLSSVAFVPCL
uniprot
proteins
function
FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23809763}.
uniprot
proteins
mass_dalton
99998
uniprot
proteins
mutagenesis
MUTAGEN 146; /note="D->F: Abolishes activation of Wnt signaling."; /evidence="ECO:0000269|PubMed:23809763"; MUTAGEN 170; /note="D->F: Abolishes activation of Wnt signaling."; /evidence="ECO:0000269|PubMed:23809763"; MUTAGEN 190; /note="A->D: Abolishes activation of Wnt signaling."; /evidence="ECO:0000269|PubMed:23809763"; MUTAGEN 861; /note="S->A: Impaired internalization to the trans-Golgi network; when associated with A-864."; /evidence="ECO:0000269|PubMed:23439653"; MUTAGEN 864; /note="S->A: Impaired internalization to the trans-Golgi network; when associated with A-861."; /evidence="ECO:0000269|PubMed:23439653
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12601349
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16575208
uniprot
proteins
pubmed
19030762
uniprot
proteins
pubmed
21693646
uniprot
proteins
pubmed
21727895
uniprot
proteins
pubmed
21909076
uniprot
proteins
pubmed
22815884
uniprot
proteins
pubmed
23439653
uniprot
proteins
pubmed
23756651
uniprot
proteins
pubmed
23809763
uniprot
proteins
pubmed
29769720
uniprot
proteins
pubmed
9642114
uniprot
proteins
pubmed
9849958
uniprot
proteins
sequence_length
907
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653). {ECO:0000269|PubMed:23439653}.
uniprot
proteins
transmembrane_region
TRANSMEM 562..582; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 594..614; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 639..659; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 683..703; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 723..743; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 768..788; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 803..823; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins