Pglyrp1
entrez
84387
canonical
uniprot
Q9JLN4
canonical
ensembl
ENSRNOG00000013395
resolver
ensp
ENSRNOP00000018233
resolver
genesymbol
Pglyrp1
resolver
genesymbol_syn
Pglyrp
resolver
genesymbol_syn
Pgrp
resolver
uniprot_entry
PGRP1_RAT
resolver
amino_acid_sequence
MLFAWAPFPALLGLADSCCFVVPRSEWKALPSECSKGLKKPVRYVVISHTAGSFCSSPDSCEQQARNVQLYQMKQLGWCDVAYNFLIGEDGHVYEGRGWTIKGDHTGPIWNPMSIGITFMGDYSHRVPAKRALRAALNLLKCGVSEGFLRSNYEVKGHRDVQSTLSPGDQLYEIIQSWDHYRE
uniprot
proteins
function
FUNCTION: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity. Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor. {ECO:0000250|UniProtKB:O75594}.
uniprot
proteins
mass_dalton
20591
uniprot
proteins
protein_family
N-acetylmuramoyl-L-alanine amidase 2 family
uniprot
proteins
pubmed
11145837
uniprot
proteins
pubmed
16641100
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasmic granule {ECO:0000250}.
uniprot
proteins