Ntsr1
entrez
366274
canonical
uniprot
P20789
canonical
ensembl
ENSRNOG00000028708
resolver
ensembl
ENSRNOG00055001097
resolver
ensembl
ENSRNOG00060001326
resolver
ensembl
ENSRNOG00065014521
resolver
ensp
ENSRNOP00000035997
resolver
ensp
ENSRNOP00055001411
resolver
ensp
ENSRNOP00060001124
resolver
ensp
ENSRNOP00065018686
resolver
enst
ENSRNOT00000039780
resolver
enst
ENSRNOT00055001811
resolver
enst
ENSRNOT00060001917
resolver
enst
ENSRNOT00065023983
resolver
genesymbol
Ntsr1
resolver
genesymbol_syn
Ntsr
resolver
uniprot_entry
NTR1_RAT
resolver
amino_acid_sequence
MHLNSSVPQGTPGEPDAQPFSGPQSEMEATFLALSLSNGSGNTSESDTAGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSGDGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMVHQAAEQGRVCTVGTHNGLEHSTFNMTIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWRHRRKKRPTFSRKPNSMSSNHAFSTSATRETLY
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:23051748, PubMed:24453215, PubMed:26205105). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (By similarity). {ECO:0000250|UniProtKB:P30989, ECO:0000269|PubMed:1694443, ECO:0000269|PubMed:23051748, ECO:0000269|PubMed:24453215, ECO:0000269|PubMed:26205105}.
uniprot
proteins
mass_dalton
47055
uniprot
proteins
mutagenesis
MUTAGEN 166; /note="E->A: Abolishes signaling via G proteins; when associated with A-310 and A-358."; /evidence="ECO:0000269|PubMed:26205105"; MUTAGEN 310; /note="L->A: Abolishes signaling via G proteins; when associated with A-166 and A-358."; /evidence="ECO:0000269|PubMed:26205105"; MUTAGEN 358; /note="F->A: Abolishes signaling via G proteins; when associated with A-166 and A-310."; /evidence="ECO:0000269|PubMed:26205105
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P30989}.; PTM: Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment. {ECO:0000250|UniProtKB:P30989}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
NTSR1 sub-subfamily
uniprot
proteins
protein_family
Neurotensin receptor subfamily
uniprot
proteins
pubmed
1694443
uniprot
proteins
pubmed
23051748
uniprot
proteins
pubmed
24453215
uniprot
proteins
pubmed
26205105
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1694443, ECO:0000269|PubMed:24453215, ECO:0000269|PubMed:26205105}; Multi-pass membrane protein {ECO:0000269|PubMed:1694443, ECO:0000269|PubMed:24453215, ECO:0000269|PubMed:26205105}. Membrane raft {ECO:0000250|UniProtKB:P30989}. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts. {ECO:0000250|UniProtKB:P30989}.
uniprot
proteins
transmembrane_region
TRANSMEM 69..89; /note="Helical; Name=1"; TRANSMEM 104..123; /note="Helical; Name=2"; TRANSMEM 144..165; /note="Helical; Name=3"; TRANSMEM 186..206; /note="Helical; Name=4"; TRANSMEM 236..260; /note="Helical; Name=5"; TRANSMEM 309..330; /note="Helical; Name=6"; TRANSMEM 349..369; /note="Helical; Name=7
uniprot
proteins