Gclc
entrez
14629
canonical
uniprot
P97494
canonical
ensembl
ENSMUSG00000032350
resolver
ensp
ENSMUSP00000034905
resolver
enst
ENSMUST00000034905
resolver
genesymbol
Gclc
resolver
genesymbol_syn
Glclc
resolver
uniprot
O09166
resolver
uniprot
Q3TEF1
resolver
uniprot
Q3UNA7
resolver
uniprot
Q8VCS5
resolver
uniprot_entry
GSH1_MOUSE
resolver
uniprot_entry
Q3TEF1_MOUSE
resolver
uniprot_entry
Q3UNA7_MOUSE
resolver
uniprot_sec
O09166
resolver
uniprot_sec
Q8VCS5
resolver
activity_regulation
ACTIVITY REGULATION: Feedback inhibition by glutathione.
uniprot
proteins
amino_acid_sequence
MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENRKVQLLLNGGDVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSVLGEHQALCTITSFPRLGCPGFTLPEHRPNPEEGGASKSLFFPDEAINKHPRFGTLTRNIRHRRGEKVVINVPIFKDKNTPSPFVETFPEDAEASKASQPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNRFRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLEEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCSKAQSSSEPAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEINYSLIWKCNQIADELCECPELLGSGFRKAKYSGGKSDPSA
uniprot
proteins
ec_number
6.3.2.2
uniprot
proteins
function
FUNCTION: Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis. {ECO:0000269|PubMed:16608839}.
uniprot
proteins
mass_dalton
72571
uniprot
proteins
pathway_participation
PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. {ECO:0000269|PubMed:16608839}.
uniprot
proteins
protein_family
Glutamate--cysteine ligase type 3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16608839
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9223101
uniprot
proteins
pubmed
9224945
uniprot
proteins
sequence_length
637
uniprot
proteins