Rspo1
entrez
192199
canonical
uniprot
Q9Z132
canonical
ensembl
ENSMUSG00000028871
resolver
ensp
ENSMUSP00000030687
resolver
ensp
ENSMUSP00000186361
resolver
enst
ENSMUST00000030687
resolver
genesymbol
Rspo1
resolver
uniprot
B1ASC1
resolver
uniprot
B2RSE3
resolver
uniprot
Q3V1S3
resolver
uniprot_entry
B1ASC1_MOUSE
resolver
uniprot_entry
B2RSE3_MOUSE
resolver
uniprot_entry
RSPO1_MOUSE
resolver
uniprot_sec
Q3V1S3
resolver
amino_acid_sequence
MRLGLCVVALVLSWTHIAVGSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCQEALYLHKGRCYPACPEGSTAANSTMECGSPAQCEMSEWSPWGPCSKKRKLCGFRKGSEERTRRVLHAPGGDHTTCSDTKETRKCTVRRTPCPEGQKRRKGGQGRRENANRHPARKNSKEPRSNSRRHKGQQQPQPGTTGPLTSVGPTWAQ
uniprot
proteins
function
FUNCTION: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes (PubMed:21693646). Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination (By similarity). Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (By similarity). {ECO:0000250|UniProtKB:Q2MKA7, ECO:0000269|PubMed:21693646}.
uniprot
proteins
mass_dalton
29332
uniprot
proteins
post_translational_modification
PTM: C-, and N-glycosylated. N-glycosylation at Asn-137, negatively influences its secretion and enhancing effect on Wnt/beta-catenin signaling. C-mannosylation at Trp-156 by DPY19L3 is required for its secretion an regulates the enhancing activity of Wnt signaling. {ECO:0000250|UniProtKB:Q2MKA7}.
uniprot
proteins
protein_family
R-spondin family
uniprot
proteins
pubmed
14732490
uniprot
proteins
pubmed
15469841
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16543246
uniprot
proteins
pubmed
17041600
uniprot
proteins
pubmed
21693646
uniprot
proteins
sequence_length
265
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16543246}. Nucleus {ECO:0000269|PubMed:14732490}. Note=Seems to mainly localize to nucleoli. {ECO:0000269|PubMed:14732490}.
uniprot
proteins