Esrrb
entrez
26380
canonical
uniprot
Q61539
canonical
ensembl
ENSMUSG00000021255
resolver
ensp
ENSMUSP00000021680
resolver
ensp
ENSMUSP00000105833
resolver
ensp
ENSMUSP00000112103
resolver
ensp
ENSMUSP00000131335
resolver
enst
ENSMUST00000021680
resolver
enst
ENSMUST00000110204
resolver
enst
ENSMUST00000116402
resolver
enst
ENSMUST00000167891
resolver
genesymbol
Esrrb
resolver
genesymbol_syn
Err-2
resolver
genesymbol_syn
Err2
resolver
genesymbol_syn
Nr3b2
resolver
uniprot
A2RTQ7
resolver
uniprot
E9QKA2
resolver
uniprot
G5E8P8
resolver
uniprot
O09067
resolver
uniprot
O09146
resolver
uniprot
Q80VS1
resolver
uniprot
Q8C7A6
resolver
uniprot
Q8CCV5
resolver
uniprot_entry
E9QKA2_MOUSE
resolver
uniprot_entry
ERR2_MOUSE
resolver
uniprot_entry
G5E8P8_MOUSE
resolver
uniprot_entry
Q80VS1_MOUSE
resolver
uniprot_entry
Q8CCV5_MOUSE
resolver
uniprot_sec
A2RTQ7
resolver
uniprot_sec
O09067
resolver
uniprot_sec
O09146
resolver
uniprot_sec
Q8C7A6
resolver
amino_acid_sequence
MSSEDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGIALSTHANGLDSPPMFAGAGLGGNPCRKSYEDCTSGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYNCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSENSPYLNLPISPPAKKPLTKIVSNLLGVEQDKLYAMPPNDIPEGDIKALTTLCELADRELVFLINWAKHIPGFPSLTLGDQMSLLQSAWMEILILGIVYRSLPYDDKLAYAEDYIMDEEHSRLVGLLDLYRAILQLVRRYKKLKVEKEEFMILKALALANSDSMYIENLEAVQKLQDLLHEALQDYELSQRHEEPRRAGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKV
uniprot
proteins
function
FUNCTION: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcriptional activity (PubMed:18662995, PubMed:18957414, PubMed:20534447, PubMed:23019124, PubMed:23169531, PubMed:23508100, PubMed:26206133, PubMed:27601327, PubMed:27723719). Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways (PubMed:18957414, PubMed:20534447, PubMed:23019124, PubMed:23040477, PubMed:23040478, PubMed:23169531, PubMed:26206133, PubMed:34397088). Involved in morula development (2-16 cells embryos) by acting as a regulator at the 8-cell stage (PubMed:39361745). Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells (PubMed:26206133). Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (PubMed:20534447). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:18662995, PubMed:18957414, PubMed:23508100). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (By similarity). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase (PubMed:27723719). Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation (PubMed:18662995, PubMed:23019124, PubMed:23169531, PubMed:26206133). This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program (PubMed:23169531). Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (PubMed:17765677, PubMed:9285590). {ECO:0000250|UniProtKB:O95718, ECO:0000269|PubMed:17765677, ECO:0000269|PubMed:18662995, ECO:0000269|PubMed:18957414, ECO:0000269|PubMed:20534447, ECO:0000269|PubMed:23019124, ECO:0000269|PubMed:23040477, ECO:0000269|PubMed:23040478, ECO:0000269|PubMed:23169531, ECO:0000269|PubMed:23508100, ECO:0000269|PubMed:26206133, ECO:0000269|PubMed:27601327, ECO:0000269|PubMed:27723719, ECO:0000269|PubMed:34397088, ECO:0000269|PubMed:39361745, ECO:0000269|PubMed:9285590}.
uniprot
proteins
mass_dalton
48328
uniprot
proteins
mutagenesis
MUTAGEN 259; /note="K->A: Loss of self-renewal in embryonic stem cells in absence of LIF. Does not interact with NCOA3."; /evidence="ECO:0000269|PubMed:23019124"; MUTAGEN 424; /note="L->A: Loss of self-renewal in embryonic stem cells in absence of LIF; when associated with A-425. Does not interact with NCOA3; when associated with A-425."; /evidence="ECO:0000269|PubMed:23019124"; MUTAGEN 425; /note="F->A: Loss of self-renewal in embryonic stem cells in absence of LIF; when associated with A-424. Does not interact with NCOA3; when associated with A-424."; /evidence="ECO:0000269|PubMed:23019124
uniprot
proteins
post_translational_modification
PTM: Acetylated by PCAF/KAT2 (in vitro). {ECO:0000250|UniProtKB:O95718}.
uniprot
proteins
protein_family
NR3 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17765677
uniprot
proteins
pubmed
18472334
uniprot
proteins
pubmed
18662995
uniprot
proteins
pubmed
18957414
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20534447
uniprot
proteins
pubmed
23019124
uniprot
proteins
pubmed
23040477
uniprot
proteins
pubmed
23040478
uniprot
proteins
pubmed
23169531
uniprot
proteins
pubmed
23508100
uniprot
proteins
pubmed
26206133
uniprot
proteins
pubmed
26523946
uniprot
proteins
pubmed
27601327
uniprot
proteins
pubmed
27723719
uniprot
proteins
pubmed
34397088
uniprot
proteins
pubmed
39361745
uniprot
proteins
pubmed
8652414
uniprot
proteins
pubmed
9285590
uniprot
proteins
sequence_length
433
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18472334}. Cytoplasm {ECO:0000269|PubMed:18472334}. Chromosome {ECO:0000269|PubMed:27723719}.
uniprot
proteins