Il24
entrez
93672
canonical
uniprot
Q925S4
canonical
ensembl
ENSMUSG00000026420
resolver
ensp
ENSMUSP00000113064
resolver
ensp
ENSMUSP00000140149
resolver
enst
ENSMUST00000121040
resolver
enst
ENSMUST00000187650
resolver
genesymbol
Il24
resolver
genesymbol_syn
Mda7
resolver
uniprot
A0A087WQD7
resolver
uniprot
A0A0R4J1N5
resolver
uniprot
A3QQZ3
resolver
uniprot
Q925J3
resolver
uniprot_entry
A0A0R4J1N5_MOUSE
resolver
uniprot_entry
IL24_MOUSE
resolver
uniprot_sec
A0A087WQD7
resolver
uniprot_sec
A3QQZ3
resolver
uniprot_sec
Q925J3
resolver
amino_acid_sequence
MLTEPAQLFVHKKNQPPSHSSLRLHFRTLAGALALSSTQMSWGLQILPCLSLILLLWNQVPGLEGQEFRFGSCQVTGVVLPELWEAFWTVKNTVQTQDDITSIRLLKPQVLRNVSGAESCYLAHSLLKFYLNTVFKNYHSKIAKFKVLRSFSTLANNFIVIMSQLQPSKDNSMLPISESAHQRFLLFRRAFKQLDTEVALVKAFGEVDILLTWMQKFYHL
uniprot
proteins
function
FUNCTION: Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:31907348, PubMed:35148201). Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (By similarity). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (PubMed:31907348). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (PubMed:35148201). {ECO:0000250|UniProtKB:Q13007, ECO:0000269|PubMed:31907348, ECO:0000269|PubMed:35148201}.; FUNCTION: [Isoform 2]: May negatively regulate isoform 1 activity by causing its retention in the endoplasmic reticulum and increasing isoform 1 degradation by the ubiquitin proteasome pathway. {ECO:0000269|PubMed:18708357}.
uniprot
proteins
mass_dalton
25168
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q13007}.; PTM: Ubiquitination at Lys-136 promotes proteasomal degradation. {ECO:0000250|UniProtKB:Q13007}.
uniprot
proteins
protein_family
IL-10 family
uniprot
proteins
pubmed
11342597
uniprot
proteins
pubmed
18708357
uniprot
proteins
pubmed
31907348
uniprot
proteins
pubmed
35148201
uniprot
proteins
sequence_length
220
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000269|PubMed:18708357}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum {ECO:0000269|PubMed:18708357}.
uniprot
proteins