Aoah
entrez
27052
canonical
uniprot
O35298
canonical
ensembl
ENSMUSG00000021322
resolver
ensp
ENSMUSP00000021757
resolver
ensp
ENSMUSP00000152286
resolver
enst
ENSMUST00000021757
resolver
enst
ENSMUST00000221982
resolver
genesymbol
Aoah
resolver
uniprot
A0A1Y7VJ47
resolver
uniprot
Q5FW74
resolver
uniprot_entry
A0A1Y7VJ47_MOUSE
resolver
uniprot_entry
AOAH_MOUSE
resolver
uniprot_entry
Q5FW74_MOUSE
resolver
amino_acid_sequence
MKFPWKVFKTTLLLLLLSHSLASVPSEDQPGDSYSHGQSCLGCVVLVSVIEQLAEVHNSSVQVAMERLCSYLPEKLFLKTACYFLVQTFGSDIIKLLDEAMKADVVCYALEFCKRGAVQPQCHLYPLPQEAWESALEKARQVLRRSSTMKYPRSGRNICSLPFLTKICQKIELSIKKAVPFKDIDSDKHSVFPTLRGYHWRGRDCNDSDKTVYPGRRPDNWDIHQDSNCNGIWGIDPKDGIPYEKKFCEGSQPRGIILLGDSAGAHFHIPPEWLTASQMSVNSFLNLPSALTDELNWPQLSGVTGFLDSTSGIEEKSIYHRLRKRNHCNHRDYQSISKNGASSRNLKNFIESLSRNQASDHPAIVLYAMIGNDVCNSKADTVPEMTTPEQMYANVMQTLTHLNSHLPNGSHVILYGLPDGTFLWDSLHNRYHPLGQLNKDVTYAQFFSFLRCLQLNPCNGWMSSNKTLRTLTSERAEQLSNTLKKIATTETFANFDLFYVDFAFHEIIEDWQKRGGQPWQLIEPVDGFHPNEVASLLQANRVWEKIQLQWPHVLGKENPFNSQIEEVFGDQGGH
uniprot
proteins
ec_number
3.1.1.77
uniprot
proteins
function
FUNCTION: Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (LPS) (PubMed:12810692, PubMed:15155618, PubMed:17322564, PubMed:19860560). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (PubMed:17322564, PubMed:19860560, PubMed:28622363). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (PubMed:18779055). {ECO:0000269|PubMed:12810692, ECO:0000269|PubMed:15155618, ECO:0000269|PubMed:17322564, ECO:0000269|PubMed:18779055, ECO:0000269|PubMed:19860560, ECO:0000269|PubMed:28622363}.
uniprot
proteins
mass_dalton
65155
uniprot
proteins
mutagenesis
MUTAGEN 262; /note="S->A: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:29343645
uniprot
proteins
post_translational_modification
PTM: Cleaved into a large and a small subunit. {ECO:0000250|UniProtKB:P28039}.; PTM: The small subunit is N-glycosylated. {ECO:0000250|UniProtKB:P28039}.
uniprot
proteins
pubmed
12810692
uniprot
proteins
pubmed
15155618
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17322564
uniprot
proteins
pubmed
18779055
uniprot
proteins
pubmed
19860560
uniprot
proteins
pubmed
28622363
uniprot
proteins
pubmed
29343645
uniprot
proteins
sequence_length
574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15155618}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P28039}. Note=Detected in urine. {ECO:0000269|PubMed:15155618}.
uniprot
proteins