SLC39A10
entrez
57181
canonical
uniprot
Q9ULF5
canonical
ensembl
ENSG00000196950
resolver
ensp
ENSP00000352655
resolver
ensp
ENSP00000386766
resolver
ensp
ENSP00000537362
resolver
ensp
ENSP00000589655
resolver
ensp
ENSP00000626135
resolver
ensp
ENSP00000745478
resolver
genesymbol
SLC39A10
resolver
genesymbol_syn
KIAA1265
resolver
genesymbol_syn
ZIP10
resolver
hgnc
HGNC:20861
resolver
uniprot
A8K5C6
resolver
uniprot
B4DGU0
resolver
uniprot
Q05C42
resolver
uniprot
Q3MJA4
resolver
uniprot
Q68CR5
resolver
uniprot
Q6DKH6
resolver
uniprot
Q9Y3Z1
resolver
uniprot_entry
Q05C42_HUMAN
resolver
uniprot_entry
S39AA_HUMAN
resolver
uniprot_sec
A8K5C6
resolver
uniprot_sec
B4DGU0
resolver
uniprot_sec
Q3MJA4
resolver
uniprot_sec
Q68CR5
resolver
uniprot_sec
Q6DKH6
resolver
uniprot_sec
Q9Y3Z1
resolver
amino_acid_sequence
MKVHMHTKFCLICLLTFIFHHCNHCHEEHDHGPEALHRQHRGMTELEPSKFSKQAAENEKKYYIEKLFERYGENGRLSFFGLEKLLTNLGLGERKVVEINHEDLGHDHVSHLDILAVQEGKHFHSHNHQHSHNHLNSENQTVTSVSTKRNHKCDPEKETVEVSVKSDDKHMHDHNHRLRHHHRLHHHLDHNNTHHFHNDSITPSERGEPSNEPSTETNKTQEQSDVKLPKGKRKKKGRKSNENSEVITPGFPPNHDQGEQYEHNRVHKPDRVHNPGHSHVHLPERNGHDPGRGHQDLDPDNEGELRHTRKREAPHVKNNAIISLRKDLNEDDHHHECLNVTQLLKYYGHGANSPISTDLFTYLCPALLYQIDSRLCIEHFDKLLVEDINKDKNLVPEDEANIGASAWICGIISITVISLLSLLGVILVPIINQGCFKFLLTFLVALAVGTMSGDALLHLLPHSQGGHDHSHQHAHGHGHSHGHESNKFLEEYDAVLKGLVALGGIYLLFIIEHCIRMFKHYKQQRGKQKWFMKQNTEESTIGRKLSDHKLNNTPDSDWLQLKPLAGTDDSVVSEDRLNETELTDLEGQQESPPKNYLCIEEEKIIDHSHSDGLHTIHEHDLHAAAHNHHGENKTVLRKHNHQWHHKHSHHSHGPCHSGSDLKETGIANIAWMVIMGDGIHNFSDGLAIGAAFSAGLTGGISTSIAVFCHELPHELGDFAVLLKAGMTVKQAIVYNLLSAMMAYIGMLIGTAVGQYANNITLWIFAVTAGMFLYVALVDMLPEMLHGDGDNEEHGFCPVGQFILQNLGLLFGFAIMLVIALYEDKIVFDIQF
uniprot
proteins
function
FUNCTION: Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essential role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250|UniProtKB:Q6P5F6, ECO:0000269|PubMed:17359283, ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30520657, ECO:0000269|PubMed:32797246}.
uniprot
proteins
mass_dalton
94132
uniprot
proteins
post_translational_modification
PTM: Undergoes N-terminal ectodomain shedding. {ECO:0000269|PubMed:32797246}.
uniprot
proteins
protein_family
ZIP transporter (TC 2.A.5) family
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17359283
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27274087
uniprot
proteins
pubmed
30520657
uniprot
proteins
pubmed
32797246
uniprot
proteins
sequence_length
831
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27274087}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:30520657}; Multi-pass membrane protein {ECO:0000255}. Note=Expressed at the apical membranes of proximal tubules in the kidney. {ECO:0000269|PubMed:30520657}.
uniprot
proteins
transmembrane_region
TRANSMEM 411..431; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 438..458; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 495..515; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 687..707; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 732..752; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 759..779; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 801..821; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins