Ipo7
entrez
233726
canonical
uniprot
Q9EPL8
canonical
ensembl
ENSMUSG00000066232
resolver
ensp
ENSMUSP00000081782
resolver
ensp
ENSMUSP00000308881
resolver
enst
ENSMUST00000084731
resolver
genesymbol
Ipo7
resolver
genesymbol_syn
Ranbp7
resolver
uniprot
Q7TN09
resolver
uniprot
Q7TQ63
resolver
uniprot
Q8BKD8
resolver
uniprot
Q8BYI0
resolver
uniprot_entry
IPO7_MOUSE
resolver
uniprot_sec
Q7TN09
resolver
uniprot_sec
Q7TQ63
resolver
uniprot_sec
Q8BKD8
resolver
uniprot_sec
Q8BYI0
resolver
amino_acid_sequence
MDPNTIIEALRGTMDPALREAAERQLNEAHKSLNFVSTLLQITMSEQLDLPVRQAGVIYLKNMITQYWPDREATPGDIAPYTIPEEDRHCIRENIVEAIIHSPELIRVQLTTCIHHIIKHDYPSRWTAIVDKIGFYLQSDNSACWLGILLCLYQLVKNYEYKKPEERSPLVAAMQHFLPVLKDRFIQLLSDQSDQSVLIQKQIFKIFYALVQYTLPLELINQQNLTEWVEILKTVVNRDVPNETLQVEEDDRPELPWWKCKKWALHILARLFERYGSPGNVSKEYNEFAEVFLKAFAVGVQQVLLKVLYQYKEKQYMAPRVLQQTLNYINQGVSHALTWKNLKPHIQGIIQDVIFPLMCYTDADEELWQEDPYEYIRMKFDVFEDFISPTTAAQTLLFTACSKRKEVLQKTMGFCYQILTEPNADPRKKDGALHMIGSLAEILLKKKIYKDQMEYMLQNHVFPLFSSELGYMRARACWVLHYFCEVKFKSDQNLQTALELTRRCLIDDREMPVKVEAAIALQVLISNQEKAKEYITPFIRPVMQALLHIIRETENDDLTNVIQKMICEYSEEVTPIAVEMTQHLAMTFNQVIQTGPDEEGSDDKAVTAMGILNTIDTLLSVVEDHKEITQQLEGICLQVIGTVLQQHVLEFYEEIFSLAHSLTCQQVSPQMWQLLPLVFEVFQQDGFDYFTDMMPLLHNYVTVDTDTLLSDTKYLEMIYSMCKKVLTGVAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVEAALERLTREVKTSELRTMCLQVAIAALYYNPHLLLNTLENLRFPNNVEPVTNHFITQWLNDVDCFLGLHDRKMCVLGLCALIDMEQIPQVLNQVSGQILPAFILLFNGLKRAYACHAEHENDSDDDEDAEDDDETEELGSDEDDIDEDGQEYLEILAKQAGEDGDDEDWEEDDAEETALEGYSTIIDDEDNPVDEYQIFKAIFQTIQNRNPVWYQALTHGLNEEQRKQLQDIATLADQRRAAHESKMIEKHGGYKFSAPVVPSSFNFGGPAPGMN
uniprot
proteins
function
FUNCTION: Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (By similarity). In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation (By similarity). Promotes odontoblast differentiation via promoting nuclear translocation of DLX3, KLF4, SMAD2, thereby facilitating the transcription of target genes that play a role in odontoblast differentiation (PubMed:33548622, PubMed:35922041). Facilitates BMP4-induced translocation of SMAD1 to the nucleus and recruitment to the MSX1 gene promoter, thereby promotes the expression of the odontogenic regulator MSX1 in dental mesenchymal cells (PubMed:34995814). Also promotes odontoblast differentiation by facilitating the nuclear translocation of HDAC6 and subsequent repression of RUNX2 expression (PubMed:35922041). Inhibits osteoblast differentiation by inhibiting nuclear translocation of RUNX2 and therefore inhibition of RUNX2 target gene transcription (PubMed:35922041). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (PubMed:11493596). {ECO:0000250|UniProtKB:O95373, ECO:0000269|PubMed:11493596, ECO:0000269|PubMed:33548622, ECO:0000269|PubMed:34995814, ECO:0000269|PubMed:35922041}.
uniprot
proteins
mass_dalton
119486
uniprot
proteins
protein_family
Importin beta family
uniprot
proteins
pubmed
11493596
uniprot
proteins
pubmed
11528126
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33548622
uniprot
proteins
pubmed
34995814
uniprot
proteins
pubmed
35922041
uniprot
proteins
sequence_length
1038
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34995814, ECO:0000269|PubMed:35922041}. Nucleus {ECO:0000269|PubMed:34995814, ECO:0000269|PubMed:35922041}. Note=Localizes to the nucleus in the presence of BMP4. {ECO:0000269|PubMed:34995814}.
uniprot
proteins