Atg14
entrez
305831
canonical
uniprot
D4A4K3
canonical
ensembl
ENSRNOG00000011873
resolver
ensembl
ENSRNOG00055023957
resolver
ensembl
ENSRNOG00060030400
resolver
ensembl
ENSRNOG00065033308
resolver
ensp
ENSRNOP00000016274
resolver
ensp
ENSRNOP00055033467
resolver
ensp
ENSRNOP00060043884
resolver
ensp
ENSRNOP00065047099
resolver
enst
ENSRNOT00000016274
resolver
enst
ENSRNOT00055041138
resolver
enst
ENSRNOT00060052793
resolver
enst
ENSRNOT00065057254
resolver
genesymbol
Atg14
resolver
genesymbol_syn
Atg14L
resolver
uniprot_entry
BAKOR_RAT
resolver
amino_acid_sequence
MASPSGKGSWTPEAPGFGPRALAPDLVDSVDDAEGLYVAVERCPLCNTTRRRLTCAKCVQSGDFVYFDGRDRERFIDKKERLSQLKNKQEEFQKEVLKAMEGKRLTDQLRWKIMSCKMRIEQLKQTICKGNEEMKKNSEGLLKNKEKNQKLYSRAQRHQEKKEKIQRHNRKLGDLVEKKTSDLREHYDRLACLRRLHILELTSVIFPMDEVKTSGRDPADVSSETDSAMTSSMVSKLAEARRTTYLSGRWVCDDHNGDTSISITGPWISLPNNGDYSAYYNWVEEKKTTQGPDMEHNNPAYTISAALGYATQLVNIVSHILDINLPKKLCNSEFCGENLSKQRLTRAVRKLNANILYLCSSQHVNLDQLQPLHTLRNLMHLVSPHSEHLGRSGPFEVRADLEESMEFVDPGVAGESDVSGDERVSDEETDLGTDWENLPSPRFCDIPSQPVEVSQSQSTQASPPIASSSAGGMISSAAASVTSWFKAYTGHR
uniprot
proteins
function
FUNCTION: Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion. Modulates the hepatic lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q6ZNE5, ECO:0000250|UniProtKB:Q8CDJ3}.
uniprot
proteins
mass_dalton
55345
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated via 'Lys-6', 'Lys-11' and 'Lys-63'-linked polyubiquitin chains on multiple lysines by MARCHF7, leading to ATG14 aggregation and loss of interaction with STX17. {ECO:0000250|UniProtKB:Q6ZNE5}.
uniprot
proteins
protein_family
ATG14 family
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6ZNE5}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6ZNE5}; Peripheral membrane protein {ECO:0000305}. Preautophagosomal structure membrane {ECO:0000250|UniProtKB:Q6ZNE5}; Peripheral membrane protein {ECO:0000305}. Note=Cytosolic under nutrient-rich conditions (By similarity). Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes (By similarity). Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By similarity). Also localizes to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:Q6ZNE5, ECO:0000250|UniProtKB:Q8CDJ3}.
uniprot
proteins