Crhr1
entrez
12921
canonical
uniprot
P35347
canonical
ensembl
ENSMUSG00000018634
resolver
ensp
ENSMUSP00000091455
resolver
enst
ENSMUST00000093925
resolver
genesymbol
Crhr1
resolver
genesymbol_syn
Crhr
resolver
uniprot
K9J9G1
resolver
uniprot
Q0VGH2
resolver
uniprot
Q3ZAT0
resolver
uniprot_entry
CRHR1_MOUSE
resolver
uniprot_entry
K9J9G1_MOUSE
resolver
uniprot_entry
Q0VGH2_MOUSE
resolver
uniprot_entry
Q3ZAT0_MOUSE
resolver
amino_acid_sequence
MGQRPQLRLVKALLLLGLNPVSTSLQDQQCESLSLASNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHIAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for CRH and UCN stress hormones, which plays a central role in whole body adaptation to stress (PubMed:11988580, PubMed:12973355, PubMed:15001778, PubMed:16339307, PubMed:17296558, PubMed:21885734, PubMed:8243652, PubMed:9620773, PubMed:9655498). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and downstream effectors, such as adenylate cyclase (PubMed:9620773). CRHR1 is mainly coupled to G(s) G protein (GNAS), mediating activation of adenylate cyclase activity and production of cAMP (PubMed:9620773). In some conditions, can also couple to G(q) G protein (GNAQ) and mediate production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers (By similarity). CRHR1-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (PubMed:15001778, PubMed:17296558, PubMed:21885734, PubMed:8243652, PubMed:9620773, PubMed:9655498). Mediates both anxiogenic and anxiolytic response to stress in glutamatergic and dopaminergic neurons, respectively (PubMed:21885734). CRHR1 also plays a critical role in addiction by mediating the brain's stress response, particularly during withdrawal and relapse: it drives the transition to compulsive drug seeking by increasing anxiety and negative emotional states (PubMed:11988580, PubMed:12973355, PubMed:15001778, PubMed:16339307, PubMed:17296558). Also involved in social behavior by triggering a signaling in the prefrontal cortex that favor social interactions with novel conspecifics over familiar ones (PubMed:37669667). {ECO:0000250|UniProtKB:P34998, ECO:0000269|PubMed:11988580, ECO:0000269|PubMed:12973355, ECO:0000269|PubMed:15001778, ECO:0000269|PubMed:16339307, ECO:0000269|PubMed:17296558, ECO:0000269|PubMed:21885734, ECO:0000269|PubMed:37669667, ECO:0000269|PubMed:8243652, ECO:0000269|PubMed:9620773, ECO:0000269|PubMed:9655498}.
uniprot
proteins
mass_dalton
47769
uniprot
proteins
post_translational_modification
PTM: C-terminal Ser or Thr residues may be phosphorylated. Phosphorylation at Ser-301 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling. {ECO:0000250|UniProtKB:P34998}.
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
11988580
uniprot
proteins
pubmed
12973355
uniprot
proteins
pubmed
15001778
uniprot
proteins
pubmed
16339307
uniprot
proteins
pubmed
17296558
uniprot
proteins
pubmed
21885734
uniprot
proteins
pubmed
23576434
uniprot
proteins
pubmed
37669667
uniprot
proteins
pubmed
8243652
uniprot
proteins
pubmed
9620773
uniprot
proteins
pubmed
9655498
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8243652}; Multi-pass membrane protein {ECO:0000255}. Note=Agonist-binding promotes endocytosis. {ECO:0000250|UniProtKB:P34998}.
uniprot
proteins
transmembrane_region
TRANSMEM 114..139; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P34998"; TRANSMEM 153..176; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P34998"; TRANSMEM 186..215; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P34998"; TRANSMEM 228..249; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P34998"; TRANSMEM 268..292; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P34998"; TRANSMEM 312..329; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P34998"; TRANSMEM 339..365; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P34998
uniprot
proteins