Kcnk9
entrez
84429
canonical
uniprot
Q9ES08
canonical
ensembl
ENSRNOG00000009265
resolver
ensembl
ENSRNOG00055026637
resolver
ensembl
ENSRNOG00060024382
resolver
ensembl
ENSRNOG00065009601
resolver
ensp
ENSRNOP00000012408
resolver
ensp
ENSRNOP00055037713
resolver
ensp
ENSRNOP00060034994
resolver
ensp
ENSRNOP00065011575
resolver
enst
ENSRNOT00000012408
resolver
enst
ENSRNOT00055045984
resolver
enst
ENSRNOT00060042200
resolver
enst
ENSRNOT00065015386
resolver
genesymbol
Kcnk9
resolver
genesymbol_syn
Task3
resolver
uniprot
Q923V6
resolver
uniprot
Q9JLD4
resolver
uniprot_entry
KCNK9_RAT
resolver
uniprot_sec
Q923V6
resolver
uniprot_sec
Q9JLD4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by halothane and isoflurane. Inhibited by external acidification, diacylglycerol, anandamide and AGT/angiotensin II. Ruthenium red inhibits homomeric but not KCNK3:KCNK9 heteromeric channels. {ECO:0000269|PubMed:10734076, ECO:0000269|PubMed:11875121, ECO:0000269|PubMed:14678492, ECO:0000269|PubMed:15282272}.
uniprot
proteins
amino_acid_sequence
MKRQNVRTLSLIACTFTYLLVGAAVFDALESDHEMREEEKLKAEEVRLRGKYNISSDDYQQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTEVSMENMVTVGFFSCMGTLCLGAAAFSQCEDWSFFHAYYYCFITLTTIGFGDFVALQSKGALQRKPFYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNTDEDLLEGEVAQILAGNPRRVVVRVPQSRKRHHPMYFLRKYGRTLCYLCFPGANWGDDDDDDDDAVENVVVTTPVPPAVAAAAAAATPGPSTRNVRATVHSVSCRVEEIPPDVLRNTYFRSPFGAIPPGMHTCGENHRLHIRRKSI
uniprot
proteins
function
FUNCTION: K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (By similarity) (PubMed:10734076, PubMed:11875121, PubMed:14678492, PubMed:15282272). Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state (By similarity). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:14678492, PubMed:15282272). Allows K(+) currents with fast-gating kinetics important for the repolarization and hyperpolarization phases of action potentials (By similarity). In granule neurons, hyperpolarizes the resting membrane potential to limit intrinsic neuronal excitability, but once the action potential threshold is reached, supports high-frequency action potential firing and increased neuronal excitability. Homomeric and/or heteromeric KCNK3:KCNK9 channels operate in cerebellar granule cells, whereas heteromeric KCNK1:KCNK9 enables currents in hippocampal dentate gyrus granule neurons (By similarity) (PubMed:14678492). Dispensable for central chemosensory respiration i.e. breathing controlled by brainstem CO2/pH, it rather conducts pH-sensitive currents and controls the firing rate of serotonergic raphe neurons involved in potentiation of the respiratory chemoreflex (By similarity). In retinal ganglion cells, mediates outward rectifying currents that regulate action potentials in response to acidification of the synaptic cleft. Involved in transmission of image-forming and nonimage-forming visual information in the retina (By similarity). In adrenal gland, contributes to the maintenance of a hyperpolarized resting membrane potential of aldosterone-producing cells at zona glomerulosa and limits aldosterone release as part of a regulatory mechanism that controls arterial blood pressure and electrolyte homeostasis (By similarity). {ECO:0000250|UniProtKB:Q3LS21, ECO:0000250|UniProtKB:Q9NPC2, ECO:0000269|PubMed:10734076, ECO:0000269|PubMed:11875121, ECO:0000269|PubMed:14678492, ECO:0000269|PubMed:15282272}.
uniprot
proteins
mass_dalton
44357
uniprot
proteins
mutagenesis
MUTAGEN 98; /note="H->D: Reduces sensitivity to alterations in external pH."; /evidence="ECO:0000269|PubMed:10734076"; MUTAGEN 191; /note="Y->F: Acts as a dominant negative when assembled with wild-type KCNK3 or KCNK9 channel subunits, abolishing K(+) flux."; /evidence="ECO:0000269|PubMed:15282272
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
10734076
uniprot
proteins
pubmed
11431495
uniprot
proteins
pubmed
11749039
uniprot
proteins
pubmed
11875121
uniprot
proteins
pubmed
14678492
uniprot
proteins
pubmed
15282272
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q3LS21}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q3LS21}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q3LS21}. Note=Colocalizes with MAP2 in the soma and proximal dendrites of dentate gyrus granule cells. {ECO:0000250|UniProtKB:Q3LS21}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 108..128; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 159..179; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins