Bst2
entrez
69550
canonical
uniprot
Q8R2Q8
canonical
ensembl
ENSMUSG00000046718
resolver
ensp
ENSMUSP00000051921
resolver
enst
ENSMUST00000051672
resolver
genesymbol
Bst2
resolver
uniprot
Q8CEY7
resolver
uniprot_entry
BST2_MOUSE
resolver
uniprot_sec
Q8CEY7
resolver
amino_acid_sequence
MAPSFYHYLPVPMDEMGGKQGWGSHRQWLGAAILVVLFGVTLVILTIYFAVTANSVACRDGLRAQAECRNTTHLLQRQLTRTQDSLLQAETQANSCNLTVVTLQESLEKKVSQALEQQARIKELENEVTKLNQELENLRIQKETSSTVQVNSGSSMVVSSLLVLKVSLFLLF
uniprot
proteins
function
FUNCTION: IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. {ECO:0000269|PubMed:16920966, ECO:0000269|PubMed:19179289, ECO:0000269|PubMed:20686043, ECO:0000269|PubMed:20702620, ECO:0000269|PubMed:21919738, ECO:0000269|PubMed:22025715, ECO:0000269|PubMed:22284121, ECO:0000269|PubMed:22327075}.
uniprot
proteins
mass_dalton
19152
uniprot
proteins
pubmed
10329429
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16920966
uniprot
proteins
pubmed
19179289
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
20686043
uniprot
proteins
pubmed
20702620
uniprot
proteins
pubmed
21084286
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21919738
uniprot
proteins
pubmed
22025715
uniprot
proteins
pubmed
22284121
uniprot
proteins
pubmed
22327075
uniprot
proteins
pubmed
22811908
uniprot
proteins
sequence_length
172
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network. Cell membrane; Single-pass type II membrane protein. Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Late endosome {ECO:0000250}. Membrane raft {ECO:0000250}. Cytoplasm {ECO:0000250}. Apical cell membrane {ECO:0000250}. Note=Shuttles between the cell membrane, where it is present predominantly in membrane/lipid rafts, and the trans-Golgi network. Forms a complex with MMP14 and localizes to the cytoplasm (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins