NEK6
entrez
10783
canonical
uniprot
Q9HC98
canonical
ensembl
ENSG00000119408
resolver
ensp
ENSP00000319734
resolver
ensp
ENSP00000362702
resolver
ensp
ENSP00000377749
resolver
ensp
ENSP00000439651
resolver
ensp
ENSP00000441426
resolver
ensp
ENSP00000441469
resolver
ensp
ENSP00000442636
resolver
ensp
ENSP00000545926
resolver
genesymbol
NEK6
resolver
hgnc
HGNC:7749
resolver
uniprot
B7Z2D9
resolver
uniprot
Q5TBG3
resolver
uniprot
Q5TBG9
resolver
uniprot
Q6FG86
resolver
uniprot
Q6IAR3
resolver
uniprot
Q96E83
resolver
uniprot
Q9ULX2
resolver
uniprot_entry
NEK6_HUMAN
resolver
uniprot_sec
B7Z2D9
resolver
uniprot_sec
Q5TBG3
resolver
uniprot_sec
Q5TBG9
resolver
uniprot_sec
Q6FG86
resolver
uniprot_sec
Q6IAR3
resolver
uniprot_sec
Q96E83
resolver
uniprot_sec
Q9ULX2
resolver
activity_regulation
ACTIVITY REGULATION: Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-108. {ECO:0000269|PubMed:19941817}.
uniprot
proteins
amino_acid_sequence
MAGQPGHMPHGGSSNNLCHTLGPVHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRPDIGYVHQVAKQMHIWMSST
uniprot
proteins
ec_number
2.7.11.34
uniprot
proteins
function
FUNCTION: Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:11516946, PubMed:14563848). Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596). Phosphorylates ATF4, CIRSR, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783). Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501). Involved in G2/M phase cell cycle arrest induced by DNA damage (PubMed:18728393). Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (PubMed:21099361). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). {ECO:0000269|PubMed:11516946, ECO:0000269|PubMed:12054534, ECO:0000269|PubMed:14563848, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:21099361, ECO:0000269|PubMed:31409757}.
uniprot
proteins
mass_dalton
35714
uniprot
proteins
mutagenesis
MUTAGEN 74; /note="K->M: Loss of autophosphorylation and of kinase activity and induction of apoptosis; when associated with M-75."; /evidence="ECO:0000269|PubMed:14563848, ECO:0000269|PubMed:19001501"; MUTAGEN 75; /note="K->M: Loss of autophosphorylation and of kinase activity and induction of apoptosis; when associated with M-74."; /evidence="ECO:0000269|PubMed:14563848, ECO:0000269|PubMed:19001501"; MUTAGEN 108; /note="Y->A: Increase in catalytic activity."; /evidence="ECO:0000269|PubMed:19941817
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Phosphorylation at Ser-206 is required for its activation. Phosphorylated upon IR or UV-induced DNA damage. Phosphorylated by CHEK1 and CHEK2. Interaction with APBB1 down-regulates phosphorylation at Thr-210. {ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14563848, ECO:0000269|PubMed:17512906, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20873783}.
uniprot
proteins
protein_family
NEK Ser/Thr protein kinase family
uniprot
proteins
protein_family
NIMA subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11516946
uniprot
proteins
pubmed
12054534
uniprot
proteins
pubmed
12840024
uniprot
proteins
pubmed
14563848
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16280549
uniprot
proteins
pubmed
16476580
uniprot
proteins
pubmed
17512906
uniprot
proteins
pubmed
18728393
uniprot
proteins
pubmed
19001501
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19414596
uniprot
proteins
pubmed
19941817
uniprot
proteins
pubmed
20407017
uniprot
proteins
pubmed
20873783
uniprot
proteins
pubmed
21099361
uniprot
proteins
pubmed
21200151
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28250205
uniprot
proteins
pubmed
31409757
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalizes with APBB1 at the nuclear speckles. Colocalizes with PIN1 in the nucleus. Colocalizes with ATF4, CIRSR, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis.
uniprot
proteins