Gjc1
entrez
14615
canonical
uniprot
P28229
canonical
ensembl
ENSMUSG00000034520
resolver
ensp
ENSMUSP00000066901
resolver
ensp
ENSMUSP00000090228
resolver
ensp
ENSMUSP00000102690
resolver
ensp
ENSMUSP00000174929
resolver
ensp
ENSMUSP00000174931
resolver
ensp
ENSMUSP00000174934
resolver
ensp
ENSMUSP00000174941
resolver
ensp
ENSMUSP00000174942
resolver
enst
ENSMUST00000068933
resolver
enst
ENSMUST00000092567
resolver
enst
ENSMUST00000107075
resolver
genesymbol
Gjc1
resolver
genesymbol_syn
Cxn-45
resolver
genesymbol_syn
Gja7
resolver
uniprot_entry
CXG1_MOUSE
resolver
amino_acid_sequence
MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDHEEDPMMYPEMELESEKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELDDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANIAQEQQYGSHEEHLPADLETLQREIRMAQERLDLAIQAYHHQNNPHGPREKKAKVGSKSGSNKSSISSKSGDGKTSVWI
uniprot
proteins
function
FUNCTION: Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage (By similarity). Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response (By similarity). {ECO:0000250|UniProtKB:A4GG66, ECO:0000250|UniProtKB:P36383}.
uniprot
proteins
mass_dalton
45666
uniprot
proteins
protein_family
Connexin family
uniprot
proteins
protein_family
Gamma-type subfamily
uniprot
proteins
pubmed
12168774
uniprot
proteins
pubmed
1322300
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19864490
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P36383}; Multi-pass membrane protein {ECO:0000255}. Cell junction, gap junction {ECO:0000250|UniProtKB:P36383}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..45; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 76..95; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 176..198; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 229..248; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins