Slc37a3
entrez
72144
canonical
uniprot
Q3TIT8
canonical
ensembl
ENSMUSG00000029924
resolver
ensp
ENSMUSP00000087709
resolver
ensp
ENSMUSP00000191930
resolver
ensp
ENSMUSP00000191931
resolver
ensp
ENSMUSP00000191936
resolver
ensp
ENSMUSP00000191941
resolver
ensp
ENSMUSP00000191947
resolver
ensp
ENSMUSP00000191962
resolver
ensp
ENSMUSP00000191971
resolver
ensp
ENSMUSP00000330047
resolver
enst
ENSMUST00000090243
resolver
genesymbol
Slc37a3
resolver
genesymbol_syn
Spx3
resolver
uniprot
A0A0R4J133
resolver
uniprot
Q4FZD9
resolver
uniprot
Q8BVX2
resolver
uniprot_entry
A0A0R4J133_MOUSE
resolver
uniprot_entry
SPX3_MOUSE
resolver
uniprot_sec
Q4FZD9
resolver
uniprot_sec
Q8BVX2
resolver
amino_acid_sequence
MAWPRFLQRGALLTSFSHHHLAVFLLTFFSYSLLHASRKTFSNVKVSISKQWTPNAFNTSLDLPAEIWSSNHLFPSTEEATLFLGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYNKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGAEESSEEDSQRPLIDGAENEDDYEPNYSIQEDRAVVQVKAISFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAPVLALSLFLAVWSLVGYSRSPNNKSINALLMTITGFFIGGPSNMVSSAISADLGRQELIQGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFILPLIVREVFSLVQRRQAHSLNE
uniprot
proteins
function
FUNCTION: Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity (By similarity). In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphosphonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol (PubMed:29745899). {ECO:0000250|UniProtKB:Q8NCC5, ECO:0000269|PubMed:29745899}.
uniprot
proteins
mass_dalton
54553
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:29745899}.
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
29745899
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8NCC5}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:29745899}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 81..101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 209..229; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 297..317; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 333..353; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 357..377; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 386..406; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 428..448; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 457..477; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins