TEAD4
entrez
7004
canonical
uniprot
Q15561
canonical
ensembl
ENSG00000197905
resolver
ensp
ENSP00000351184
resolver
ensp
ENSP00000352926
resolver
ensp
ENSP00000380311
resolver
genesymbol
TEAD4
resolver
genesymbol_syn
RTEF1
resolver
genesymbol_syn
TCF13L1
resolver
genesymbol_syn
TEF3
resolver
hgnc
HGNC:11717
resolver
uniprot
H0Y308
resolver
uniprot
Q6MZR9
resolver
uniprot
Q8NEV5
resolver
uniprot
Q92883
resolver
uniprot
Q96BK2
resolver
uniprot_entry
TEAD4_HUMAN
resolver
uniprot_sec
H0Y308
resolver
uniprot_sec
Q6MZR9
resolver
uniprot_sec
Q8NEV5
resolver
uniprot_sec
Q92883
resolver
uniprot_sec
Q96BK2
resolver
amino_acid_sequence
MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE
uniprot
proteins
function
FUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
uniprot
proteins
mass_dalton
48329
uniprot
proteins
mutagenesis
MUTAGEN 266; /note="D->A: Reduced transforming ability."; /evidence="ECO:0000269|PubMed:20123908"; MUTAGEN 297; /note="K->A: Important loss of interaction with YAP1 and complete loss of transforming ability."; /evidence="ECO:0000269|PubMed:20123908"; MUTAGEN 299; /note="W->A: Important loss of interaction with YAP1 and complete loss of transforming ability."; /evidence="ECO:0000269|PubMed:20123908"; MUTAGEN 337; /note="F->A: Reduced interaction with YAP1."; /evidence="ECO:0000269|PubMed:20123908"; MUTAGEN 373; /note="F->A: Reduced transforming ability."; /evidence="ECO:0000269|PubMed:20123908"; MUTAGEN 380; /note="L->A: Reduced transforming ability."; /evidence="ECO:0000269|PubMed:20123908"; MUTAGEN 391; /note="E->A: Reduced transforming ability."; /evidence="ECO:0000269|PubMed:20123908"; MUTAGEN 393; /note="F->A: Reduced transforming ability."; /evidence="ECO:0000269|PubMed:20123908"; MUTAGEN 427; /note="H->A: Reduced transforming ability."; /evidence="ECO:0000269|PubMed:20123908"; MUTAGEN 429; /note="Y->A,H: Loss of interaction with YAP1 and also activation by YAP1."; /evidence="ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:20123908"; MUTAGEN 429; /note="Y->A: Important loss of interaction with YAP1 and complete loss of transforming ability."; /evidence="ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:20123908
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18579750
uniprot
proteins
pubmed
19324877
uniprot
proteins
pubmed
20123908
uniprot
proteins
pubmed
8702974
uniprot
proteins
pubmed
8921372
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins