TNFRSF14
entrez
8764
canonical
uniprot
Q92956
canonical
ensembl
ENSG00000157873
resolver
ensembl
ENSG00000273936
resolver
ensp
ENSP00000347948
resolver
ensp
ENSP00000386859
resolver
ensp
ENSP00000399292
resolver
ensp
ENSP00000399533
resolver
ensp
ENSP00000485884
resolver
ensp
ENSP00000530841
resolver
ensp
ENSP00000530842
resolver
ensp
ENSP00000530843
resolver
ensp
ENSP00000530845
resolver
ensp
ENSP00000662540
resolver
ensp
ENSP00000662542
resolver
ensp
ENSP00000708550
resolver
ensp
ENSP00000708554
resolver
enst
ENST00000409119
resolver
enst
ENST00000625695
resolver
genesymbol
TNFRSF14
resolver
genesymbol_syn
HVEA
resolver
genesymbol_syn
HVEM
resolver
hgnc
HGNC:11912
resolver
uniprot
B3KW30
resolver
uniprot
B9A034
resolver
uniprot
B9DI89
resolver
uniprot
Q6IB95
resolver
uniprot
Q8N634
resolver
uniprot
Q8WXR1
resolver
uniprot
Q96J31
resolver
uniprot
Q9UM65
resolver
uniprot_entry
B9A034_HUMAN
resolver
uniprot_entry
TNR14_HUMAN
resolver
uniprot_sec
B3KW30
resolver
uniprot_sec
B9DI89
resolver
uniprot_sec
Q6IB95
resolver
uniprot_sec
Q8N634
resolver
uniprot_sec
Q8WXR1
resolver
uniprot_sec
Q96J31
resolver
uniprot_sec
Q9UM65
resolver
amino_acid_sequence
MEPPGDWGPPPWRSTPKTDVLRLVLYLTFLGAPCYAPALPSCKEDEYPVGSECCPKCSPGYRVKEACGELTGTVCEPCPPGTYIAHLNGLSKCLQCQMCDPAMGLRASRNCSRTENAVCGCSPGHFCIVQDGDHCAACRAYATSSPGQRVQKGGTESQDTLCQNCPPGTFSPNGTLEECQHQTKCSWLVTKAGAGTSSSHWVWWFLSGSLVIVIVCSTVGLIICVKRRKPRGDVVKVIVSVQRKRQEAEGEATVIEALQAPPDVTTVAVEETIPSFTGRSPNH
uniprot
proteins
function
FUNCTION: Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed:10754304, PubMed:18193050, PubMed:23761635, PubMed:9462508). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044, PubMed:9153189, PubMed:9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed:10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (By similarity) (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (By similarity) (PubMed:19915044). {ECO:0000250|UniProtKB:Q80WM9, ECO:0000269|PubMed:10754304, ECO:0000269|PubMed:18193050, ECO:0000269|PubMed:19915044, ECO:0000269|PubMed:23761635, ECO:0000269|PubMed:9153189, ECO:0000269|PubMed:9162022, ECO:0000269|PubMed:9462508}.; FUNCTION: (Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1. {ECO:0000269|PubMed:11511370, ECO:0000269|PubMed:8898196, ECO:0000269|PubMed:9696799}.; FUNCTION: (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2. {ECO:0000269|PubMed:11511370, ECO:0000269|PubMed:9696799}.
uniprot
proteins
mass_dalton
30392
uniprot
proteins
mutagenesis
MUTAGEN 61; /note="Y->A: Abolishes cis interactions with BTLA."; /evidence="ECO:0000269|PubMed:19915044"; MUTAGEN 61; /note="Y->F: Does not affect cis interactions with BTLA."; /evidence="ECO:0000269|PubMed:19915044
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:16169851}.
uniprot
proteins
protein_family
Tumor necrosis factor receptor superfamily
uniprot
proteins
pubmed
10754304
uniprot
proteins
pubmed
11511370
uniprot
proteins
pubmed
11756979
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16169851
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18193050
uniprot
proteins
pubmed
19915044
uniprot
proteins
pubmed
23761635
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8898196
uniprot
proteins
pubmed
9153189
uniprot
proteins
pubmed
9162022
uniprot
proteins
pubmed
9162061
uniprot
proteins
pubmed
9462508
uniprot
proteins
pubmed
9696799
uniprot
proteins
sequence_length
283
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19915044}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins