ARL4C
entrez
10123
canonical
uniprot
P56559
canonical
ensembl
ENSG00000188042
resolver
ensp
ENSP00000339754
resolver
ensp
ENSP00000375057
resolver
genesymbol
ARL4C
resolver
genesymbol_syn
ARL7
resolver
hgnc
HGNC:698
resolver
uniprot
Q4A519
resolver
uniprot
Q53R10
resolver
uniprot
Q9BVN1
resolver
uniprot
Q9UQ34
resolver
uniprot_entry
ARL4C_HUMAN
resolver
uniprot_sec
Q4A519
resolver
uniprot_sec
Q53R10
resolver
uniprot_sec
Q9BVN1
resolver
uniprot_sec
Q9UQ34
resolver
amino_acid_sequence
MGNISSNISAFQSLHIVMLGLDSAGKTTVLYRLKFNEFVNTVPTIGFNTEKIKLSNGTAKGISCHFWDVGGQEKLRPLWKSYSRCTDGIIYVVDSVDVDRLEEAKTELHKVTKFAENQGTPLLVIANKQDLPKSLPVAEIEKQLALHELIPATTYHVQPACAIIGEGLTEGMDKLYEMILKRRKSLKQKKKR
uniprot
proteins
function
FUNCTION: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process. {ECO:0000269|PubMed:15147902, ECO:0000269|PubMed:17398095, ECO:0000269|PubMed:19409876}.
uniprot
proteins
mass_dalton
21487
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Cytoplasmic localization."; /evidence="ECO:0000269|PubMed:15147902, ECO:0000269|PubMed:17398095"; MUTAGEN 27; /note="T->N: Does not interact with alpha tubulin."; /evidence="ECO:0000269|PubMed:19409876"; MUTAGEN 34; /note="K->N: Cytoplasmic localization. Increases GDP-form."; /evidence="ECO:0000269|PubMed:17398095"; MUTAGEN 72; /note="Q->L: Does not interact with alpha tubulin. Activates transferrin transport from early endosome to recycling endosome."; /evidence="ECO:0000269|PubMed:19409876
uniprot
proteins
protein_family
Arf family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10462049
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15147902
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17398095
uniprot
proteins
pubmed
19409876
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, filopodium. Cell membrane. Cytoplasm.
uniprot
proteins