Pcm1
entrez
18536
canonical
uniprot
Q9R0L6
canonical
ensembl
ENSMUSG00000031592
resolver
ensp
ENSMUSP00000039709
resolver
ensp
ENSMUSP00000147887
resolver
ensp
ENSMUSP00000246035
resolver
ensp
ENSMUSP00000246036
resolver
ensp
ENSMUSP00000246037
resolver
ensp
ENSMUSP00000246038
resolver
ensp
ENSMUSP00000246039
resolver
ensp
ENSMUSP00000246049
resolver
ensp
ENSMUSP00000246054
resolver
ensp
ENSMUSP00000331711
resolver
genesymbol
Pcm1
resolver
uniprot
E9QLK2
resolver
uniprot
O70287
resolver
uniprot
Q3URH6
resolver
uniprot
Q7TMS7
resolver
uniprot
Q8C9V2
resolver
uniprot
Q91Y27
resolver
uniprot
Q91Y28
resolver
uniprot
Q91Y51
resolver
uniprot
Q923L0
resolver
uniprot
Q9CRK8
resolver
uniprot
Q9CT57
resolver
uniprot_entry
PCM1_MOUSE
resolver
uniprot_sec
E9QLK2
resolver
uniprot_sec
O70287
resolver
uniprot_sec
Q3URH6
resolver
uniprot_sec
Q7TMS7
resolver
uniprot_sec
Q8C9V2
resolver
uniprot_sec
Q91Y27
resolver
uniprot_sec
Q91Y28
resolver
uniprot_sec
Q91Y51
resolver
uniprot_sec
Q923L0
resolver
uniprot_sec
Q9CRK8
resolver
uniprot_sec
Q9CT57
resolver
amino_acid_sequence
MATGGGPFEEVMHDQDLPNWSNDSVDDRLNNMEWGGQQKKANRSSEKNKKKFGVASDKRVTNAISPESSPGVGRRRTKIPHTFPHSRYMTQMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDATASLPKREMTTSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIEHLKEQEKSYMKFLQKILARDPQQEPMEETENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVTETTGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREISQSRNPSVSEHLPDEKVQLFSKMRVLQEKKQKMDKLLGELHNLRDQHLNNSSFVPSTSLQRSGDKRSSTVALSAPVGFASAVNGEANSLISSVPCPATSLVSQNESENEGHLNPAEKLQKLNEVQKRLNELRELVHYYEQTSDMMTDAVNENTKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNTNSNTQCGSNNRDGRPVNSNCEINNRSAANIRALNMPPLDCRYNREGEQRLHVAHGEDEEEEVEEEGVSGASLSSRRSSLVDEAPEDEEFEQKISRLMAAKEKLKQLQDLVAMVQDDDATQVVVPAASNLDDFYAAEEDIKQNSNNARENSNKIDTGVNEKTREKFYEAKLQQQQRELKQLQEERKKLIEIQEKIQAVQKACPDLQLSATSISSGPTKKYLPAITSTPTVNENDSSTSKCVIDPEDSSVVDNELWSDMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETSSPVAISLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFPIYPPSMNQNSYNVKETKTRWKSNRPVSADGNYRPLAKTRQQNISMQRQENLRWVSELSYIEEKEQWQEQINQLKKQLDFSVNICQTLMQDQQTLSCLLQTLLTGPYSVLPSNVASPQVHLIMHQLNQCYTQLTWQQNNVQRLKQMLTELMRQQNQHPEKPRSKERGSSASHPSSPNLFCPFSFPTQPVNLFNLPGFTNFPSFAPGMNFSPLFPSNFGDFSQNVSTPTEQQQPLAQNPSGKTEYMAFPKPFESSSSLGAEKQRNQKQPEEEAENTKTPWLYDQEGGVEKPFFKTGFTESVEKATNSNRKNQPDTSRRRRQFDEESLESFSSMPDPIDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIGYESASVSSTCEPCKNRNRHSAQTEEPVQAKLFSRKNHEQLEKIIKYSRSAEISSETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESDEREGENVKPVNSGTWVASNSELTPSESLVTTDDETFEKNFERETHKVSEQNDADNVSVMSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTETESHSNMRCTCRVIEDEDGAAAAATVSNSEETPIIENHNSPQPISDVSAVPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSIAVKQRCKRKIEAAGVRQSYAKEAKRILEGDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDAKGPKNVRSDVSDQEEDEESERCPVSINLSKAESQALTNYGSGEDENEDEEMEDFEESPVDIQTSLQANTETTEENEHDSQILQHDLEKTPESTNVPSDQEPTSKNDQDSSPVKPCYLNILENEQQLNSATHKDSLTTTDSSKQPEPLPLPLAASETLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTVYSEEELRKKMIEEEQKNHLSGEICEMQTEELAGNSQILKEPETVGAQSI
uniprot
proteins
function
FUNCTION: Required for centrosome assembly and function (PubMed:12112146). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (By similarity). Required to anchor microtubules to the centrosome (By similarity). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites (PubMed:27979967). Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites (By similarity). {ECO:0000250|UniProtKB:Q15154, ECO:0000269|PubMed:12112146, ECO:0000269|PubMed:27979967}.
uniprot
proteins
mass_dalton
228847
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Undergoes monoubiquitination catalyzed by the E3 ubiquitin-protein ligase MIB1 in proliferating cells, preventing cilia formation. Monoubiquitination by MIB1 is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, resulting in cilia formation initiation. {ECO:0000250|UniProtKB:Q15154}.; PTM: Phosphorylated on multiple serine and threonine residues by DYRK3 during the G2-to-M transition, after the nuclear-envelope breakdown. Phosphorylation by DYRK3 promotes disassembly of pericentriolar material (By similarity). Phosphorylation at Ser-372 mediated by PLK4 is required to maintain the integrity of centriolar satellites (By similarity). {ECO:0000250|UniProtKB:Q15154}.
uniprot
proteins
protein_family
PCM1 family
uniprot
proteins
pubmed
10579718
uniprot
proteins
pubmed
12112146
uniprot
proteins
pubmed
12403812
uniprot
proteins
pubmed
12466851
uniprot
proteins
pubmed
12571289
uniprot
proteins
pubmed
15107855
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17705300
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24356449
uniprot
proteins
pubmed
24469809
uniprot
proteins
pubmed
26643951
uniprot
proteins
pubmed
27979967
uniprot
proteins
pubmed
9680377
uniprot
proteins
sequence_length
2025
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8AV28}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10579718, ECO:0000269|PubMed:12112146, ECO:0000269|PubMed:12403812}. Cytoplasmic granule {ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:12571289}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:10579718, ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:12571289}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q15154}. Note=Recruitment to the centrosome requires microtubules and dynein. Displaced from centriolar satellites and centrosome in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAP kinase signaling (By similarity). The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to the cleavage site in telophase. {ECO:0000250|UniProtKB:Q15154}.
uniprot
proteins