Oprl1
entrez
29256
canonical
uniprot
P35370
canonical
ensembl
ENSRNOG00000016768
resolver
ensembl
ENSRNOG00055001262
resolver
ensembl
ENSRNOG00060001471
resolver
ensembl
ENSRNOG00065014024
resolver
ensp
ENSRNOP00000030087
resolver
ensp
ENSRNOP00055001632
resolver
ensp
ENSRNOP00060001392
resolver
ensp
ENSRNOP00065018063
resolver
enst
ENSRNOT00000031328
resolver
enst
ENSRNOT00055002097
resolver
enst
ENSRNOT00060002205
resolver
enst
ENSRNOT00065023194
resolver
genesymbol
Oprl1
resolver
genesymbol_syn
Oor
resolver
genesymbol_syn
Oprl
resolver
uniprot
F7FLX3
resolver
uniprot
Q791R4
resolver
uniprot_entry
F7FLX3_RAT
resolver
uniprot_entry
OPRX_RAT
resolver
uniprot_sec
Q791R4
resolver
amino_acid_sequence
MESLFPAPYWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASSLHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
uniprot
proteins
function
FUNCTION: G protein-coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. {ECO:0000269|PubMed:15937148, ECO:0000269|PubMed:18588920}.
uniprot
proteins
mass_dalton
40523
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-360 requires GRK3. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11290428
uniprot
proteins
pubmed
15937148
uniprot
proteins
pubmed
18588920
uniprot
proteins
pubmed
7798930
uniprot
proteins
pubmed
7877452
uniprot
proteins
pubmed
8026588
uniprot
proteins
pubmed
8034018
uniprot
proteins
pubmed
8034019
uniprot
proteins
pubmed
8163014
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle {ECO:0000250}. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface (By similarity). Internalization requires phosphorylation at Ser-360. Can recycle to the cell membrane. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..71; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 85..106; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 122..143; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 163..185; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 209..233; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 262..282; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 298..319; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins