SKA2
entrez
348235
canonical
uniprot
Q8WVK7
canonical
ensembl
ENSG00000182628
resolver
ensp
ENSP00000333433
resolver
ensp
ENSP00000411231
resolver
ensp
ENSP00000462574
resolver
enst
ENST00000583380
resolver
genesymbol
SKA2
resolver
genesymbol_syn
FAM33A
resolver
hgnc
HGNC:28006
resolver
uniprot
A6NIL3
resolver
uniprot
B3KPL3
resolver
uniprot
E9PCB8
resolver
uniprot
J3KSP0
resolver
uniprot_entry
J3KSP0_HUMAN
resolver
uniprot_entry
SKA2_HUMAN
resolver
uniprot_sec
A6NIL3
resolver
uniprot_sec
B3KPL3
resolver
uniprot_sec
E9PCB8
resolver
amino_acid_sequence
MEAEVDKLELMFQKAESDLDYIQYRLEYEIKTNHPDSASEKNPVTLLKELSVIKSRYQTLYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMPDL
uniprot
proteins
function
FUNCTION: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:23085020}.
uniprot
proteins
mass_dalton
14188
uniprot
proteins
protein_family
SKA2 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17093495
uniprot
proteins
pubmed
18583474
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19289083
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23085020
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083}. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins. {ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083}.
uniprot
proteins