THUMPD2
entrez
80745
canonical
uniprot
Q9BTF0
canonical
ensembl
ENSG00000138050
resolver
ensp
ENSP00000423933
resolver
ensp
ENSP00000603867
resolver
ensp
ENSP00000603872
resolver
ensp
ENSP00000659863
resolver
ensp
ENSP00000681573
resolver
genesymbol
THUMPD2
resolver
genesymbol_syn
C2orf8
resolver
hgnc
HGNC:14890
resolver
uniprot
A8K7I7
resolver
uniprot
B4DP37
resolver
uniprot
Q53TT8
resolver
uniprot
Q53TV0
resolver
uniprot
Q969Z2
resolver
uniprot_entry
B4DP37_HUMAN
resolver
uniprot_entry
Q969Z2_HUMAN
resolver
uniprot_entry
THUM2_HUMAN
resolver
uniprot_sec
A8K7I7
resolver
uniprot_sec
Q53TT8
resolver
uniprot_sec
Q53TV0
resolver
amino_acid_sequence
MSEARGEPGSGPEAGARFFCTAGRGLEPFVMREVRARLAATQVEYISGKVFFTTCSDLNMLKKLKSAERLFLLIKKQFPLIISSVSKGKIFNEMQRLINEDPGSWLNAISIWKNLLELDAKKEKLSQRDDNQLKRKVGENEIIAKKLKIEQMQKIEENRDCQLEKQIKEETLEQRDFTTKSEKFQEEEFQNDIEKAIDTHNQNDLTFRVSCRCSGTIGKAFTAQEVGKVIGIAIMKHFGWKADLRNPQLEIFIHLNDIYSVVGIPVFRVSLASRAYIKTAGLRSTIAWAMASLADIKAGAFVLDPMCGLGTILLEAAKEWPDVYYVGADVSDSQLLGTWDNLKAAGLEDKIELLKISVIELPLPSESVDIIISDIPFGKKFKLGKDIKSILQEMERVLHVGGTIVLLLSEDHHRRLTDCKESNIPFNSKDSHTDEPGIKKCLNPEEKTGAFKTASTSFEASNHKFLDRMSPFGSLVPVECYKVSLGKTDAFICKYKKSHSSGL
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Catalytic subunit of the THUMPD2-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotides, most probably at position 72 (m2G72), in the U6snRNA of the major spliceosome (PubMed:37283053). This modification in the U6 snRNA affects the constitutive splicing efficiency of introns that have suboptimal splice sites and can impact final mRNA levels (PubMed:37283053). {ECO:0000269|PubMed:37283053}.
uniprot
proteins
mass_dalton
56433
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
12063391
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
34948388
uniprot
proteins
pubmed
37283053
uniprot
proteins
sequence_length
503
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34948388}.
uniprot
proteins