Add3
entrez
25230
canonical
uniprot
Q62847
canonical
ensembl
ENSRNOG00000012820
resolver
ensembl
ENSRNOG00065011403
resolver
ensp
ENSRNOP00000017600
resolver
ensp
ENSRNOP00000043399
resolver
ensp
ENSRNOP00000109495
resolver
ensp
ENSRNOP00000110239
resolver
ensp
ENSRNOP00000112493
resolver
genesymbol
Add3
resolver
uniprot
D3ZCH7
resolver
uniprot
G3V9D7
resolver
uniprot_entry
ADDG_RAT
resolver
uniprot_sec
D3ZCH7
resolver
uniprot_sec
G3V9D7
resolver
amino_acid_sequence
MSSDTSQAVITTPPPPSMPHKERYFDRINESDPEYLRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHDPTGLLALQQIADYIMANSFTGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLADLFGWAHLANTYISVRVSKEQDHIIIIPRGLSFSEATASALVKVNIIGEVVDQGSTNLKIDHSGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLILGDVAYYDYQGSLDEEEERIELQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQMACEIQVQAVAGAGGVDNLLILDLQKYKAFTHGVAMTGGGGVNMGSHQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLVREKPRHKSDVEIPATVTAFSFEDDSVPLSPLKYMAQRQQREKTRWLNSPNTYMKVNVPEESRNGETSPRTKITWMKAEDPSKVSSGTPIKIEDPNQFVPLNTNPTEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSTMRFEDDDQGPPAPPNPFSHLMEGELEEYTKTIERKQQGLDDAEQESLSDDAASVSQIQSQTQSPQSVPERLEENHELFSKSFTSVDVPVIVNGKDEMHDVEDELAQRVSRLTTSTTIENIEITIKSPDRTEEVLSPDGSPSKSPSKKKKKFRTPSFLKKNKKKEKVEA
uniprot
proteins
function
FUNCTION: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin (By similarity). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure (PubMed:27927653, PubMed:32029431, PubMed:32830539). Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo (PubMed:27927653, PubMed:32029431). Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension (PubMed:32830539, PubMed:33414130). Involved in renal blood flow (RBF) autoregulation (PubMed:32029431, PubMed:32830539, PubMed:33414130). Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement (PubMed:33308016). Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (PubMed:33414130). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q9QYB5, ECO:0000250|UniProtKB:Q9UEY8, ECO:0000269|PubMed:27927653, ECO:0000269|PubMed:32029431, ECO:0000269|PubMed:32830539, ECO:0000269|PubMed:33308016, ECO:0000269|PubMed:33414130}.
uniprot
proteins
mass_dalton
78818
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000250}.; PTM: Proteolytically cleaved by asparagine endopeptidase (AEP) into 2 fragments. Overexpression of the 1-357 fragment induces neuronal apoptosis, and overexpression of either 1-357 or 358-706 fragment increases the degeneration of dendritic spines. Overexpression of the 1-357 fragment impairs neurite outgrowth by down-regulating the expression of Rac2, and induces synaptic dysfunction and cognitive impairments in tau P301S transgenic mice, a mouse model for Alzheimer disease (AD). {ECO:0000250|UniProtKB:Q9QYB5}.
uniprot
proteins
protein_family
Adducin subfamily
uniprot
proteins
protein_family
Aldolase class II family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15632090
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
27927653
uniprot
proteins
pubmed
32029431
uniprot
proteins
pubmed
32830539
uniprot
proteins
pubmed
33308016
uniprot
proteins
pubmed
33414130
uniprot
proteins
pubmed
7592723
uniprot
proteins
pubmed
9299427
uniprot
proteins
sequence_length
705
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:7592723}. Cell membrane {ECO:0000269|PubMed:32029431, ECO:0000269|PubMed:33308016}; Peripheral membrane protein; Cytoplasmic side. Cytoplasm {ECO:0000250|UniProtKB:Q9QYB5}. Note=Full-length protein and the cleavage fragment 358-706 localize mainly to the cytoplasm, while cleavage fragment 1-357 translocates from the cytoplasm to the nucleus. {ECO:0000250|UniProtKB:Q9QYB5}.
uniprot
proteins