Scn10a
entrez
29571
canonical
uniprot
Q62968
canonical
ensembl
ENSRNOG00000032473
resolver
ensp
ENSRNOP00000047944
resolver
genesymbol
Scn10a
resolver
genesymbol_syn
Sns
resolver
uniprot
Q63554
resolver
uniprot
Q6EWG6
resolver
uniprot_entry
SCNAA_RAT
resolver
uniprot_sec
Q63554
resolver
uniprot_sec
Q6EWG6
resolver
amino_acid_sequence
MELPFASVGTTNFRRFTPESLAEIEKQIAAHRAAKKARTKHRGQEDKGEKPRPQLDLKACNQLPKFYGELPAELVGEPLEDLDPFYSTHRTFMVLNKSRTISRFSATWALWLFSPFNLIRRTAIKVSVHSWFSIFITITILVNCVCMTRTDLPEKVEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGAAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGLQLFKGNLKNKCIRNGTDPHKADNLSSEMAEYIFIKPGTTDPLLCGNGSDAGHCPGGYVCLKTPDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIFLGSFYLVNLILAVVTMAYEEQSQATIAEIEAKEKKFQEALEVLQKEQEVLAALGIDTTSLQSHSGSPLASKNANERRPRVKSRVSEGSTDDNRSPQSDPYNQRRMSFLGLSSGRRRASHGSVFHFRAPSQDISFPDGITDDGVFHGDQESRRGSILLGRGAGQTGPLPRSPLPQSPNPGRRHGEEGQLGVPTGELTAGAPEGPALDTTGQKSFLSAGYLNEPFRAQRAMSVVSIMTSVIEELEESKLKCPPCLISFAQKYLIWECCPKWRKFKMALFELVTDPFAELTITLCIVVNTVFMAMEHYPMTDAFDAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSASKKGSLSVLRTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTFILAIIVFIFALVGKQLLSEDYGCRKDGVSVWNGEKLRWHMCDFFHSFLVVFRILCGEWIENMWVCMEVSQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQLALARIQVLGHRASRAIASYISSHCRFRWPKVETQLGMKPPLTSSEAKNHIATDAVSAAVGNLTKPALSSPKENHGDFITDPNVWVSVPIAEGESDLDELEEDMEQASQSSWQEEDPKGQQEQLPQVQKCENHQAARSPASMMSSEDLAPYLGESWKRKDSPQVPAEGVDDTSSSEGSTVDCPDPEEILRKIPELADDLDEPDDCFTEGCTRRCPCCNVNTSKSPWATGWQVRKTCYRIVEHSWFESFIIFMILLSSGALAFEDNYLEEKPRVKSVLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILEYSDVASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFSKCVDTRNNPFSNVNSTMVNNKSECHNQNSTGHFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSGEINSQPNWENNLYMYLYFVVFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFVFDIVTRQAFDIIIMVLICLNMITMMVETDEQGEEKTKVLGRINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVILSIGSLLFSAILKSLENYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMASFANVVDEAGIDDMFNFKTFGNSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGIIFFTTYIIISFLIVVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFIAFSALSDFADTLSGPLRIPKPNQNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKTNMEEKFMATNLSKASYEPIATTLRWKQEDLSATVIQKAYRSYMLHRSLTLSNTLHVPRAEEDGVSLPGEGYVTFMANSGLPDKSETASATSFPPSYDSVTRGLSDRANINPSSSMQNEDEVAAKEGNSPGPQ
uniprot
proteins
function
FUNCTION: Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. {ECO:0000269|PubMed:12514212, ECO:0000269|PubMed:8538791, ECO:0000269|PubMed:8626372}.
uniprot
proteins
mass_dalton
219733
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by NEDD4L; which promotes its endocytosis. {ECO:0000250}.; PTM: Phosphorylation at Ser-1452 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. {ECO:0000250}.; PTM: Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 815) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4. {ECO:0000250|UniProtKB:P15389}.
uniprot
proteins
protein_family
Nav1.8/SCN10A subfamily
uniprot
proteins
protein_family
Sodium channel (TC 1.A.1.10) family
uniprot
proteins
pubmed
11487631
uniprot
proteins
pubmed
12050667
uniprot
proteins
pubmed
12514212
uniprot
proteins
pubmed
12591166
uniprot
proteins
pubmed
15047701
uniprot
proteins
pubmed
15178439
uniprot
proteins
pubmed
8538791
uniprot
proteins
pubmed
8626372
uniprot
proteins
pubmed
9450690
uniprot
proteins
sequence_length
1956
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:D0E0C2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}. Note=It can be translocated to the cell membrane through association with S100A10. {ECO:0000269|PubMed:12050667}.
uniprot
proteins
transmembrane_region
TRANSMEM 126..149; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 155..174; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 188..206; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 213..232; /note="Helical; Voltage-sensor; Name=S4 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 249..272; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 373..398; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 659..683; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 695..718; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 727..746; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 753..772; /note="Helical; Voltage-sensor; Name=S4 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 789..809; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 864..889; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 1149..1172; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1186..1211; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1218..1239; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1244..1265; /note="Helical; Voltage-sensor; Name=S4 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1285..1312; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1393..1419; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1473..1496; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1508..1531; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1538..1561; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1574..1595; /note="Helical; Voltage-sensor; Name=S4 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1611..1633; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1699..1723; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000255
uniprot
proteins