Has1
entrez
15116
canonical
uniprot
Q61647
canonical
ensembl
ENSMUSG00000003665
resolver
ensp
ENSMUSP00000003762
resolver
enst
ENSMUST00000003762
resolver
genesymbol
Has1
resolver
genesymbol_syn
Has
resolver
uniprot
Q3UUP6
resolver
uniprot_entry
HYAS1_MOUSE
resolver
uniprot_entry
Q3UUP6_MOUSE
resolver
amino_acid_sequence
MRQDMPKPSEAARCCSGLARRALTIIFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGAFLSAHLVAQSLFAYLEHRRVAAAARRSLAKGPLDAATARSVALTISAYQEDPAYLRQCLTSARALLYPHTRLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAEATGAVGEGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSRCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVLRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCVRMVLLSLYAPLYMCGLLPAKFLALVTMNQSGWGTSGRKKLAANYVPVLPLALWALLLLGGLARSVAQEARADWSGPSRAAEAYHLAAGAGAYVAYWVVMLTIYWVGVRRLCRRRSGGYRVQV
uniprot
proteins
ec_number
2.4.1.212
uniprot
proteins
function
FUNCTION: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential for the synthesis of hyaluronan, a major component of most extracellular matrices that has a structural role in tissue architecture and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate. {ECO:0000269|PubMed:10455188}.
uniprot
proteins
mass_dalton
65545
uniprot
proteins
mutagenesis
MUTAGEN 242; /note="D->E: Loss of both activities."; /evidence="ECO:0000269|PubMed:10617644"; MUTAGEN 311; /note="S->N: No effect."; /evidence="ECO:0000269|PubMed:10617644"; MUTAGEN 312; /note="G->P: No effect."; /evidence="ECO:0000269|PubMed:10617644"; MUTAGEN 313; /note="P->G: No effect."; /evidence="ECO:0000269|PubMed:10617644"; MUTAGEN 314; /note="L->I: 75% decrease of both activities."; /evidence="ECO:0000269|PubMed:10617644"; MUTAGEN 314; /note="L->V: Loss of HA activity."; /evidence="ECO:0000269|PubMed:10617644"; MUTAGEN 344; /note="D->E: Loss of both activities."; /evidence="ECO:0000269|PubMed:10617644"; MUTAGEN 380; /note="Q->N: 85%-90% decrease of both activities."; /evidence="ECO:0000269|PubMed:10617644"; MUTAGEN 383; /note="R->K: 85%-90% decrease of both activities."; /evidence="ECO:0000269|PubMed:10617644"; MUTAGEN 384; /note="W->Y: Loss of both activities."; /evidence="ECO:0000269|PubMed:10617644
uniprot
proteins
pathway_participation
PATHWAY: Glycan biosynthesis; hyaluronan biosynthesis. {ECO:0000269|PubMed:10455188}.
uniprot
proteins
protein_family
NodC/HAS family
uniprot
proteins
pubmed
10455188
uniprot
proteins
pubmed
10617644
uniprot
proteins
pubmed
8626618
uniprot
proteins
sequence_length
583
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 52..72; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 405..425; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 436..456; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 463..483; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 502..522; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 546..566; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins