Ccm2
entrez
216527
canonical
uniprot
Q8K2Y9
canonical
ensembl
ENSMUSG00000000378
resolver
ensp
ENSMUSP00000000388
resolver
ensp
ENSMUSP00000105343
resolver
ensp
ENSMUSP00000105344
resolver
ensp
ENSMUSP00000297995
resolver
enst
ENSMUST00000109721
resolver
enst
ENSMUST00000109722
resolver
genesymbol
Ccm2
resolver
genesymbol_syn
Osm
resolver
uniprot
F7AVU1
resolver
uniprot
F8WJD3
resolver
uniprot
Q5SUA3
resolver
uniprot_entry
CCM2_MOUSE
resolver
uniprot_entry
F7AVU1_MOUSE
resolver
uniprot_sec
F8WJD3
resolver
uniprot_sec
Q5SUA3
resolver
amino_acid_sequence
MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLALPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDKAKRSHQLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAGSLSESAVGPVEACCLVIMATESKVAAEELCSLLSQVFQIVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDMKDSYDADASTFCFPDSGDVGGLPPLPFCMQTSPHSKTVSESELSTSATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCISLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSTSTINGNRTTGSPDDRSAPSEGDEWDRMISDISSDIEALGCSMDQDSA
uniprot
proteins
function
FUNCTION: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock. {ECO:0000269|PubMed:14634666, ECO:0000269|PubMed:19151727}.
uniprot
proteins
mass_dalton
49917
uniprot
proteins
protein_family
CCM2 family
uniprot
proteins
pubmed
14634666
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19151727
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14634666}. Note=Treatment with sorbitol caused relocalization to ruffle-like structures.
uniprot
proteins