Agbl5
entrez
231093
canonical
uniprot
Q09M02
canonical
ensembl
ENSMUSG00000029165
resolver
ensp
ENSMUSP00000063228
resolver
ensp
ENSMUSP00000110348
resolver
ensp
ENSMUSP00000143808
resolver
ensp
ENSMUSP00000143934
resolver
ensp
ENSMUSP00000144018
resolver
ensp
ENSMUSP00000281510
resolver
ensp
ENSMUSP00000281512
resolver
ensp
ENSMUSP00000281513
resolver
ensp
ENSMUSP00000281515
resolver
ensp
ENSMUSP00000281516
resolver
ensp
ENSMUSP00000333947
resolver
ensp
ENSMUSP00000333949
resolver
genesymbol
Agbl5
resolver
genesymbol_syn
Ccp5
resolver
uniprot
D3Z6S8
resolver
uniprot
Q09M01
resolver
uniprot
Q09M03
resolver
uniprot
Q09M04
resolver
uniprot
Q6PFZ3
resolver
uniprot
Q8BLL9
resolver
uniprot
Q8BM52
resolver
uniprot
Q8BZD8
resolver
uniprot
Q8C0W4
resolver
uniprot_entry
CBPC5_MOUSE
resolver
uniprot_sec
D3Z6S8
resolver
uniprot_sec
Q09M01
resolver
uniprot_sec
Q09M03
resolver
uniprot_sec
Q09M04
resolver
uniprot_sec
Q6PFZ3
resolver
uniprot_sec
Q8BLL9
resolver
uniprot_sec
Q8BM52
resolver
uniprot_sec
Q8BZD8
resolver
uniprot_sec
Q8C0W4
resolver
amino_acid_sequence
MELRCGGLLFSSRFDSGNLAHVEKVETVSSDGEGVGGVATAPASGSAASPDYEFNVWTRPDCAETEYENGNRSWFYFSVRGGTPGKLIKINIMNMNKQSKLYSQGMAPFVRTLPSRPRWERIRERPTFEMTETQFVLSFVHRFVEGRGATTFFAFCYPFSYSDCQDLLSQLDQRFSENYSTHSSPLDSIYYHRELLCYSLDGLRVDLLTITSCHGLRDDREPRLEQLFPDLGTPRPFRFTGKRIFFLSSRVHPGETPSSFVFNGFLDFILRPDDPRAQTLRRLFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLKPDAVLHPAIYGAKAVLLYHHVHSRLNAKSPTNQQPTLHLPPEAPLSDLEKANNLHNEAHLGQSPDGENPATWPETEPAEEKTDPVWLMPQPIPELEEPAPDTIPPKESGVAYYVDLHGHASKRGCFMYGNSFSDESTQVENMLYPKLISLNSAHFDFQGCNFSEKNMYARDRRDGQSKEGSGRVAIYKASGIIHSYTLECNYNTGRSVNSIPAACHDNGRASPPPPPAFPSRYTVELFEQVGRAMAIAALDMAECNPWPRIVLSEHSSLTNLRAWMLRHVRNSRGLTSAGNMGASKKRGARTPPKSNNSLPVSCSENALSRVRSFSTGTSTGGSSSSQQNSPQMKNSPSFPFHGSRTAGLPGLGSSTQKVSHRVLGPVREPRCSDRRRRQQPLNHRSTTSSLAPSPTLASSGPTSSRNMGSCLLPNSLSLSGSSCSFSSSGDKPEAVMVIGKSLLGAGARIPCIRTRLQARPRLGRSSPPTRRGMRGSSPTSPIPQTRESSELEPGPHSATPGLPQAGPPRPRSAPAFSPISCTLSDSPSRICYSRGLLNQCEVCFVPKSPPLTISPRV
uniprot
proteins
ec_number
3.4.17.-
uniprot
proteins
ec_number
3.4.17.24
uniprot
proteins
function
FUNCTION: Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins (PubMed:20519502, PubMed:21074048, PubMed:24022482, PubMed:26829768). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed:20519502, PubMed:21074048, PubMed:24022482). Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate (PubMed:21074048, PubMed:24022482). Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin (PubMed:24022482). Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation (PubMed:26829768). {ECO:0000269|PubMed:20519502, ECO:0000269|PubMed:21074048, ECO:0000269|PubMed:24022482, ECO:0000269|PubMed:26829768}.
uniprot
proteins
mass_dalton
97607
uniprot
proteins
mutagenesis
MUTAGEN 252; /note="H->S: Abolishes deglutamylase activity; when associated with Q-255."; /evidence="ECO:0000269|PubMed:21074048, ECO:0000269|PubMed:26829768"; MUTAGEN 255; /note="E->Q: Abolishes deglutamylase activity; when associated with S-252."; /evidence="ECO:0000269|PubMed:21074048, ECO:0000269|PubMed:26829768
uniprot
proteins
protein_family
Peptidase M14 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17244818
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20519502
uniprot
proteins
pubmed
21074048
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24022482
uniprot
proteins
pubmed
25103237
uniprot
proteins
pubmed
26829768
uniprot
proteins
sequence_length
886
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17244818, ECO:0000269|PubMed:24022482}. Nucleus {ECO:0000269|PubMed:17244818}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8NDL9}. Midbody {ECO:0000250|UniProtKB:Q8NDL9}. Note=Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis (By similarity). Mainly cytoplasmic. Slight accumulation in the nucleus is observed (PubMed:17244818). {ECO:0000250|UniProtKB:Q8NDL9, ECO:0000269|PubMed:17244818}.
uniprot
proteins