MED1
entrez
5469
canonical
uniprot
Q15648
canonical
ensembl
ENSG00000125686
resolver
ensp
ENSP00000300651
resolver
ensp
ENSP00000377828
resolver
genesymbol
MED1
resolver
genesymbol_syn
ARC205
resolver
genesymbol_syn
CRSP1
resolver
genesymbol_syn
CRSP200
resolver
genesymbol_syn
DRIP205
resolver
genesymbol_syn
DRIP230
resolver
genesymbol_syn
PBP
resolver
genesymbol_syn
PPARBP
resolver
genesymbol_syn
PPARGBP
resolver
genesymbol_syn
RB18A
resolver
genesymbol_syn
TRAP220
resolver
genesymbol_syn
TRIP2
resolver
hgnc
HGNC:9234
resolver
uniprot
A2RRQ6
resolver
uniprot
O43810
resolver
uniprot
O75447
resolver
uniprot
Q6P9H7
resolver
uniprot
Q6PK58
resolver
uniprot
Q9HD39
resolver
uniprot_entry
MED1_HUMAN
resolver
uniprot_sec
A2RRQ6
resolver
uniprot_sec
O43810
resolver
uniprot_sec
O75447
resolver
uniprot_sec
Q6P9H7
resolver
uniprot_sec
Q6PK58
resolver
uniprot_sec
Q9HD39
resolver
amino_acid_sequence
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSAGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
uniprot
proteins
function
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
uniprot
proteins
mass_dalton
168478
uniprot
proteins
mutagenesis
MUTAGEN 599..612; /note="SQNPILTSLLQITG->EKHKILHRLLQDSS: Enhances interaction with ESR1."; /evidence="ECO:0000269|PubMed:11303023"; MUTAGEN 600..612; /note="QNPILTSLLQITG->RHKILHRLLQEGS: Enhances interaction with ESR1."; /evidence="ECO:0000269|PubMed:12556447"; MUTAGEN 604; /note="L->A: Impairs interaction with ESR2; when associated with A-607; A-645 and A-648."; /evidence="ECO:0000269|PubMed:11303023"; MUTAGEN 607..608; /note="LL->AA: Impairs interaction with ESR1, PPARG, RXRA and THRB. Impairs interaction with THRA; when associated with 648-A-A-649."; /evidence="ECO:0000269|PubMed:10733574, ECO:0000269|PubMed:10770935, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:9653119"; MUTAGEN 607; /note="L->A: Impairs interaction with ESR2; when associated with A-604; A-645 and A-648."; /evidence="ECO:0000269|PubMed:11303023"; MUTAGEN 639..653; /note="TKNHPMLMNLLKDNP->VSRHKILHRLLQEGS: Enhances interaction with ESR1."; /evidence="ECO:0000269|PubMed:12556447"; MUTAGEN 645; /note="L->A: Impairs interaction with ESR2; when associated with A-604; A-607 and A-648."; /evidence="ECO:0000269|PubMed:11303023"; MUTAGEN 648..649; /note="LL->AA: Impairs interaction with ESR1, PPARG, THRB and VDR. Impairs interaction with THRA; when associated with 607-A-A-608."; /evidence="ECO:0000269|PubMed:10733574, ECO:0000269|PubMed:10770935, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:9653119"; MUTAGEN 648; /note="L->A: Impairs interaction with ESR2; when associated with A-604; A-607 and A-645."; /evidence="ECO:0000269|PubMed:11303023"; MUTAGEN 886; /note="S->D: Increased interaction with PSIP1; when associated with D-887 or D-887 and D-889."; /evidence="ECO:0000269|PubMed:29997176"; MUTAGEN 887; /note="S->D: Phosphomimetic mutant. Increased interaction with PSIP1; when associated with D-886 or D-886 and D-889."; /evidence="ECO:0000269|PubMed:29997176"; MUTAGEN 889; /note="S->D: Increased interaction with PSIP1; when associated with D-886 and D-887."; /evidence="ECO:0000269|PubMed:29997176"; MUTAGEN 1032; /note="T->A: Enhances protein stability; when associated with A-1457."; /evidence="ECO:0000269|PubMed:16314496"; MUTAGEN 1457; /note="T->A: Enhances protein stability; when associated with A-1032."; /evidence="ECO:0000269|PubMed:16314496
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the nucleolus (PubMed:16314496). Phosphorylation increases its interaction with PSIP1 (PubMed:29997176). {ECO:0000269|PubMed:16314496, ECO:0000269|PubMed:29997176}.
uniprot
proteins
protein_family
Mediator complex subunit 1 family
uniprot
proteins
pubmed
10024883
uniprot
proteins
pubmed
10235266
uniprot
proteins
pubmed
10235267
uniprot
proteins
pubmed
10406464
uniprot
proteins
pubmed
10478845
uniprot
proteins
pubmed
10733574
uniprot
proteins
pubmed
10770935
uniprot
proteins
pubmed
11303023
uniprot
proteins
pubmed
11867769
uniprot
proteins
pubmed
12034878
uniprot
proteins
pubmed
12037571
uniprot
proteins
pubmed
12218053
uniprot
proteins
pubmed
12556447
uniprot
proteins
pubmed
14636573
uniprot
proteins
pubmed
15175163
uniprot
proteins
pubmed
15340084
uniprot
proteins
pubmed
15471764
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15989967
uniprot
proteins
pubmed
16314496
uniprot
proteins
pubmed
16574658
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17000779
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19786558
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24245781
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29997176
uniprot
proteins
pubmed
7776974
uniprot
proteins
pubmed
9444950
uniprot
proteins
pubmed
9653119
uniprot
proteins
sequence_length
1581
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:16314496, ECO:0000269|PubMed:16574658}. Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.
uniprot
proteins