Cnot8
entrez
69125
canonical
uniprot
Q9D8X5
canonical
ensembl
ENSMUSG00000020515
resolver
ensp
ENSMUSP00000020822
resolver
ensp
ENSMUSP00000104471
resolver
ensp
ENSMUSP00000170021
resolver
ensp
ENSMUSP00000170026
resolver
enst
ENSMUST00000020822
resolver
enst
ENSMUST00000108843
resolver
genesymbol
Cnot8
resolver
uniprot
Q3U532
resolver
uniprot_entry
CNOT8_MOUSE
resolver
uniprot_sec
Q3U532
resolver
amino_acid_sequence
MPAALVENSQVICEVWASNLEEEMRKIREIVLSYSYIAMDTEFPGVVVRPIGEFRSSIDYQYQLLRCNVDLLKIIQLGLTFTNEKGEYPSGINTWQFNFKFNLTEDMYSQDSIDLLANSGLQFQKHEEEGIDTLHFAELLMTSGVVLCDNVKWLSFHSGYDFGYMVKLLTDSRLPEEEHEFFHILNLFFPSIYDVKYLMKSCKNLKGGLQEVADQLDLQRIGRQHQAGSDSLLTGMAFFRMKELFFEDSIDDAKYCGRLYGLGTGVAQKQNEDVDCAQEKMSILAMINNMQQ
uniprot
proteins
ec_number
3.1.13.4
uniprot
proteins
function
FUNCTION: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex also seems to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. {ECO:0000269|PubMed:22367759}.
uniprot
proteins
mass_dalton
33574
uniprot
proteins
protein_family
CAF1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22367759
uniprot
proteins
pubmed
27065194
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins