Ccdc25
entrez
67179
canonical
uniprot
Q78PG9
canonical
ensembl
ENSMUSG00000022035
resolver
ensp
ENSMUSP00000022614
resolver
enst
ENSMUST00000022614
resolver
genesymbol
Ccdc25
resolver
uniprot
A0PK78
resolver
uniprot
Q9CSQ8
resolver
uniprot
Q9CUF8
resolver
uniprot_entry
A0PK78_MOUSE
resolver
uniprot_entry
CCD25_MOUSE
resolver
uniprot_sec
Q9CSQ8
resolver
uniprot_sec
Q9CUF8
resolver
amino_acid_sequence
MVFYFTSSSVNSSTYTIYMGKDKYENEDLIKYGWPEDIWFHVDKLSSAHVYLRLQKGEKIEDIPKEVLMDCAHLVKANSIQGCKMNNVNVVYTPWSNLKKTADMDVGQIGFHRQKDVKIVTVEKKVNEILNRLEKTKLEKFPDLAAEKEGRDREERNEKKAQIQEMKRKEKEEMKKKREMDELRSYSSLMKVENMSSNQDGNDSDEFM
uniprot
proteins
function
FUNCTION: Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility. NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (By similarity). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (By similarity). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (By similarity). {ECO:0000250|UniProtKB:Q86WR0}.
uniprot
proteins
mass_dalton
24480
uniprot
proteins
protein_family
CCDC25 family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32528174
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86WR0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q86WR0}. Endomembrane system {ECO:0000250|UniProtKB:Q86WR0}. Note=Localizes to cytoplasmic membrane in tumor cells. {ECO:0000250|UniProtKB:Q86WR0}.
uniprot
proteins
transmembrane_region
TRANSMEM 106..122; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins