Tiam2
entrez
24001
canonical
uniprot
Q6ZPF3
canonical
ensembl
ENSMUSG00000023800
resolver
ensp
ENSMUSP00000072020
resolver
ensp
ENSMUSP00000125842
resolver
ensp
ENSMUSP00000302888
resolver
ensp
ENSMUSP00000302889
resolver
ensp
ENSMUSP00000302890
resolver
genesymbol
Tiam2
resolver
genesymbol_syn
Kiaa2016
resolver
genesymbol_syn
Stef
resolver
uniprot
Q3TSM6
resolver
uniprot
Q3TZ33
resolver
uniprot
Q6AXF2
resolver
uniprot
Q6NXJ2
resolver
uniprot
Q9JLY2
resolver
uniprot
Q9WVS3
resolver
uniprot_entry
TIAM2_MOUSE
resolver
uniprot_sec
Q3TSM6
resolver
uniprot_sec
Q3TZ33
resolver
uniprot_sec
Q6AXF2
resolver
uniprot_sec
Q6NXJ2
resolver
uniprot_sec
Q9JLY2
resolver
uniprot_sec
Q9WVS3
resolver
amino_acid_sequence
MGNSESQYTFQGSKNHSNTVTGAKQKPCSLKIRSVHAKDEKSLHGWTHGSSGAGYKSRSLARSCLSHFKNHQPYATRLSGPTCKVSKGTTYSKHRANTPGNDFQGNSGAFLPENGFHYVDRESEESHITSNGHLLTCYGRKESLASTPPGEDHRSPRVLIKTLGKLDGCLRVEFHNGGNPHKGTSEDPSGPVRLLRYSPTLASETCPVRETRRHSAAGSPSSQRPSPTDSRLRSSKGSSLSSESSWYDSPWGNAGEVSEVEGSFLAPSTPDPSLPSSFPPSDTKKPFNQSSSLSSLRELYKDPNLGCRSPSGTCLSSNEYISSQVSLNNRVSFASDMDVPSRVDHRDPLHYSSFTLPCRKSKALTEDAAKKDTLKARMRRFSDWTGSLSRKKRKLQEPRSMEGSEYFDSHSDGLNAEGQVPAQTSSLLWSGGSAQTLPHRSESTHAISVDPLRQNIYENFMRELEMSRSNTEHVETSTETMESSSESVSSLEQLDLLFEKEQGVVRKAGWLFFKPLVTLQKERKLELVARRKWKQYWVTLKGCTLLFYETYGKNSTEQNSAPRCALFAEDSIVQSVPEHPKKEHVFCLSNSCGDVYLFQATSQTDLENWVTAIHSACASLFAKKHGKEDTVRLLKSQTRSLLQKIDMDSKMKKMAELQLSVVSDPKNRKAIENQIRQWEQNLEKFHMDLFRMRCYLASLQGGELPNPKSLLAATSRPSKLALGRLGVLSVSSFHALVCSRDDSTLRKRTLSLTQRGKSKKGIFSSLKGLDTLARKGREKRASITQMFDSSHSHGFLGTQLPQKSTNSNKAHDLHLYGSAVDSALRDSMWEVQTYVHFQDNEGVTVTIKPEHRVEDVLALVCKMRQLEPTHYGLQLRKVVDKSVEWCVPALYEYMQEQVYDEIEVFPLSVYDVQLTKTGDMTDFGFAVTVQVDEHQHLNRIFISDVLPDSLAYGGGLRKGNEITSLNGEPVSDLDIQQMEALFSEKSVGLTLVARPVTTRRTLCASWSDSDLFSRDQKSLPPSPNQSQLLEEFLDNFRKTATSDFSNVPEITTGLKRSQTEGTLDQVPHREKMEQTFLSADQIAELCRDLNNTHTNSMEAPTESHDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDAISASSDFSVLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQRVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDHESEEHYHLTEALKAMEKVASHINEMQKIYEDYGMVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDIELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNSADLDPFKFRWLIPISALQVRLGNTAGTENNSTWELIHTKSEIEGRPETIFQLCCSDSENKTSIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSLKGLRTSSSSEWPSEPSKGNSLDSDECSLSSGTQSSGCPVAESRRDSKSTELEKDAQEGLAEFPDGLIKESDILSDEDEDFHHPLKQGSPTKDIEIQFQRLKISEESDVHPVGQQPLTESGEQPKLVRGHFCPIKRKANSTKRGRGTLLKAQTRHQSLDSHPETASIDLNLVLEREFSVQSLTSVVNEEGFYETQSHGKS
uniprot
proteins
function
FUNCTION: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. {ECO:0000269|PubMed:10364228, ECO:0000269|PubMed:11707441, ECO:0000269|PubMed:12912917, ECO:0000269|PubMed:14550769, ECO:0000269|PubMed:17320046}.
uniprot
proteins
mass_dalton
192567
uniprot
proteins
mutagenesis
MUTAGEN 1655; /note="S->A: No change of phosphorylation by Rho-kinase."; /evidence="ECO:0000269|PubMed:17320046"; MUTAGEN 1656; /note="T->A: No change of phosphorylation by Rho-kinase."; /evidence="ECO:0000269|PubMed:17320046"; MUTAGEN 1662; /note="T->A: Strongly decrease phosphorylation by Rho-kinase. No change in promoting neurite growth; when associated with A-1668 and A-1672."; /evidence="ECO:0000269|PubMed:17320046"; MUTAGEN 1668; /note="T->A: Slight decrease phosphorylation by Rho-kinase. No change in promoting neurite growth; when associated with A-1662 and A-1672."; /evidence="ECO:0000269|PubMed:17320046"; MUTAGEN 1672; /note="S->A: Slight decrease phosphorylation by Rho-kinase. No change in promoting neurite growth; when associated with A-1662 and A-1668."; /evidence="ECO:0000269|PubMed:17320046
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1662 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth. {ECO:0000269|PubMed:17320046}.
uniprot
proteins
protein_family
TIAM family
uniprot
proteins
pubmed
10364228
uniprot
proteins
pubmed
10512681
uniprot
proteins
pubmed
11707441
uniprot
proteins
pubmed
11900975
uniprot
proteins
pubmed
12912917
uniprot
proteins
pubmed
14550769
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17320046
uniprot
proteins
pubmed
19893486
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1715
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14550769}. Cell projection, lamellipodium {ECO:0000269|PubMed:14550769}. Cell projection, filopodium {ECO:0000269|PubMed:14550769}. Cell projection, growth cone {ECO:0000269|PubMed:11707441, ECO:0000269|PubMed:14550769}. Cell projection, neuron projection {ECO:0000269|PubMed:11707441, ECO:0000269|PubMed:14550769}. Perikaryon {ECO:0000269|PubMed:11707441}.
uniprot
proteins