E2F6
entrez
1876
canonical
uniprot
O75461
canonical
ensembl
ENSG00000169016
resolver
ensp
ENSP00000302159
resolver
ensp
ENSP00000370936
resolver
ensp
ENSP00000438864
resolver
ensp
ENSP00000446315
resolver
ensp
ENSP00000677235
resolver
genesymbol
E2F6
resolver
hgnc
HGNC:3120
resolver
uniprot
A0A0S2Z3K8
resolver
uniprot
A8K2Z8
resolver
uniprot
G5E936
resolver
uniprot
O60544
resolver
uniprot
Q53QY9
resolver
uniprot
Q53YM3
resolver
uniprot
Q6Q9Z5
resolver
uniprot
Q6Q9Z6
resolver
uniprot
Q7Z2H6
resolver
uniprot_entry
A0A0S2Z3K8_HUMAN
resolver
uniprot_entry
E2F6_HUMAN
resolver
uniprot_entry
Q53YM3_HUMAN
resolver
uniprot_entry
Q6Q9Z5_HUMAN
resolver
uniprot_sec
A8K2Z8
resolver
uniprot_sec
G5E936
resolver
uniprot_sec
O60544
resolver
uniprot_sec
Q53QY9
resolver
uniprot_sec
Q6Q9Z6
resolver
uniprot_sec
Q7Z2H6
resolver
amino_acid_sequence
MSQQRPARKLPSLLLDPTEETVRRRCRDPINVEGLLPSKIRINLEDNVQYVSMRKALKVKRPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRRVYDITNVLDGIDLVEKKSKNHIRWIGSDLSNFGAVPQQKKLQEELSDLSAMEDALDELIKDCAQQLFELTDDKENERLAYVTYQDIHSIQAFHEQIVIAVKAPAETRLDVPAPREDSITVHIRSTNGPIDVYLCEVEQGQTSNKRSEGVGTSSSESTHPEGPEEEENPQQSEELLEVSN
uniprot
proteins
function
FUNCTION: Inhibitor of E2F-dependent transcription (PubMed:9501179, PubMed:9689056, PubMed:9704927). Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' (PubMed:9501179). Has a preference for the 5'-TTTCCCGC-3' E2F recognition site (PubMed:9501179). E2F6 lacks the transcriptional activation and pocket protein binding domains (PubMed:9501179, PubMed:9704927). Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (PubMed:9501179, PubMed:9689056). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (By similarity). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (PubMed:9501179). {ECO:0000250|UniProtKB:O54917, ECO:0000269|PubMed:9501179, ECO:0000269|PubMed:9689056, ECO:0000269|PubMed:9704927}.
uniprot
proteins
mass_dalton
31844
uniprot
proteins
mutagenesis
MUTAGEN 68; /note="L->E: Reduction in repressor activity, little effect on S-phase entry."; /evidence="ECO:0000269|PubMed:9689056
uniprot
proteins
protein_family
E2F/DP family
uniprot
proteins
pubmed
12004135
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15081404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15960975
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
9501179
uniprot
proteins
pubmed
9689056
uniprot
proteins
pubmed
9704927
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9689056, ECO:0000269|PubMed:9704927}.
uniprot
proteins