EPPIN
entrez
57119
canonical
uniprot
O95925
canonical
ensembl
ENSG00000101448
resolver
ensembl
ENSG00000249139
resolver
ensp
ENSP00000361746
resolver
ensp
ENSP00000765965
resolver
genesymbol
EPPIN
resolver
genesymbol
SPINLW1
resolver
genesymbol_syn
SPINLW1
resolver
genesymbol_syn
WAP7
resolver
genesymbol_syn
WFDC7
resolver
hgnc
HGNC:15932
resolver
hgnc
HGNC:38825
resolver
uniprot
A0A384NYB9
resolver
uniprot
A6PVD6
resolver
uniprot
B2R4Q0
resolver
uniprot
Q86TP9
resolver
uniprot
Q96SD7
resolver
uniprot
Q9HD30
resolver
uniprot_entry
A0A384NYB9_HUMAN
resolver
uniprot_entry
B2R4Q0_HUMAN
resolver
uniprot_entry
EPPI_HUMAN
resolver
uniprot_sec
A6PVD6
resolver
uniprot_sec
Q86TP9
resolver
uniprot_sec
Q96SD7
resolver
uniprot_sec
Q9HD30
resolver
amino_acid_sequence
MGSSGLLSLLVLFVLLANVQGPGLTDWLFPRRCPKIREECEFQERDVCTKDRQCQDNKKCCVFSCGKKCLDLKQDVCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQSKANCLNTCKNKRFP
uniprot
proteins
function
FUNCTION: Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility. {ECO:0000269|PubMed:15229136, ECO:0000269|PubMed:17644992}.
uniprot
proteins
mass_dalton
15284
uniprot
proteins
mutagenesis
MUTAGEN 87; /note="L->G: Loss of effect on KLK3 activity."; /evidence="ECO:0000269|PubMed:17644992"; MUTAGEN 102; /note="C->A: Reduces the binding to SEMG1 by 45%."; /evidence="ECO:0000269|PubMed:22699487"; MUTAGEN 107; /note="Y->A: Reduces the binding to SEMG1 by 68%."; /evidence="ECO:0000269|PubMed:22699487"; MUTAGEN 110; /note="C->A: Does not affect the binding of SEMG1 or LTF. Does not affect the binding of SEMG1; when associated with A-123 and A-127."; /evidence="ECO:0000269|PubMed:22699487"; MUTAGEN 117; /note="F->A: Reduces the binding to SEMG1 by 68% and to LTF by 73%."; /evidence="ECO:0000269|PubMed:22699487"; MUTAGEN 123; /note="C->A: Does not affect the binding of SEMG1 or LTF. Does not affect the binding of SEMG1; when associated with A-110 and A-127."; /evidence="ECO:0000269|PubMed:22699487"; MUTAGEN 127; /note="C->A: Does not affect the binding of SEMG1 or LTF. Does not affect the binding of SEMG1; when associated with A-110 and A-123."; /evidence="ECO:0000269|PubMed:22699487
uniprot
proteins
pubmed
11404006
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15229136
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15590901
uniprot
proteins
pubmed
17567961
uniprot
proteins
pubmed
17644992
uniprot
proteins
pubmed
18331357
uniprot
proteins
pubmed
21461566
uniprot
proteins
pubmed
22699487
uniprot
proteins
sequence_length
133
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Secreted. Cell surface. Note=Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa.
uniprot
proteins