Oxt
entrez
25504
canonical
uniprot
P01179
canonical
ensembl
ENSRNOG00000021225
resolver
ensembl
ENSRNOG00055006164
resolver
ensembl
ENSRNOG00060006527
resolver
ensembl
ENSRNOG00060017639
resolver
ensembl
ENSRNOG00065014569
resolver
ensp
ENSRNOP00000028829
resolver
ensp
ENSRNOP00055007713
resolver
ensp
ENSRNOP00060007920
resolver
ensp
ENSRNOP00060024355
resolver
ensp
ENSRNOP00065018773
resolver
enst
ENSRNOT00000028829
resolver
enst
ENSRNOT00055009988
resolver
enst
ENSRNOT00060010688
resolver
enst
ENSRNOT00060030171
resolver
enst
ENSRNOT00065024071
resolver
genesymbol
Oxt
resolver
genesymbol_syn
Ot
resolver
uniprot
Q53WU2
resolver
uniprot_entry
NEU1_RAT
resolver
uniprot_sec
Q53WU2
resolver
amino_acid_sequence
MACPSLACCLLGLLALTSACYIQNCPLGGKRAALDLDMRKCLPCGPGGKGRCFGPSICCADELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCATAGICCSPDGCRTDPACDPESAFSER
uniprot
proteins
function
FUNCTION: Precursor of oxytocin, a neurohypophyseal hormone that plays a key role in social interactions and neurophysin 1, its carrier protein. {ECO:0000269|PubMed:6326097}.; FUNCTION: [Oxytocin]: Neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection (PubMed:17170309, PubMed:17925443, PubMed:21719680). Released in response to a variety of social cues and acts by binding to oxytocin receptor (OXTR), triggering signaling that modulates neural circuits by altering ion channel activity, changing intrinsic neuronal properties and modifying synaptic transmission (both excitatory and inhibitory) (PubMed:17170309, PubMed:21719680). Central release (direct secretion in the brain) plays essential roles in social behavior, such as maternal care, male mating behavior, social cognition and affiliative behaviors (PubMed:17170309, PubMed:21719680). Stressful and anxiogenic stimuli promote release of oxytocin, which acts as a powerful modulator of anxiety- and stress-related behaviors (PubMed:21719680). Modulates neural circuits related to reward, fear and social approach, encouraging care and cooperation, but can also increase guilt or aggression towards out-groups (By similarity). Beyond its role in social behavior, plays a role in other processes, such as parturition, lactation or osteoblast differentiation, when released peripherally (secreted from the posterior pituitary gland into the bloodstream) (By similarity). Required for parturition and milk ejection by triggering and strengthening contraction of the smooth muscle of the uterus and mammary gland, respectively (By similarity). Promotes bone mass by stimulating bone formation by osteoblasts (By similarity). {ECO:0000250|UniProtKB:P01178, ECO:0000250|UniProtKB:P35454, ECO:0000269|PubMed:17170309, ECO:0000269|PubMed:17925443, ECO:0000269|PubMed:21719680}.; FUNCTION: [Neurophysin 1]: Carrier protein that binds to and transports oxytocin from the hypothalamus to the posterior pituitary gland, protecting it from degradation and facilitating its release. {ECO:0000269|PubMed:6153132}.
uniprot
proteins
mass_dalton
12823
uniprot
proteins
post_translational_modification
PTM: Synthesized as a large inactive precursor protein (pro-OXT), which is cleaved into oxytocin and neurophysin 1 by endopeptidases, such as neuroendocrine convertases PCSK1 and PCSK2 (PubMed:9523585). Oxytocin is then amidated at the C-terminus, completing its activation (PubMed:5150741). {ECO:0000269|PubMed:5150741, ECO:0000269|PubMed:9523585}.; PTM: [Oxytocin]: Amidated at the C-terminus by alpha-amidating monooxygenase (PAM), completing its activation. {ECO:0000269|PubMed:5150741}.
uniprot
proteins
protein_family
Vasopressin/oxytocin family
uniprot
proteins
pubmed
1371278
uniprot
proteins
pubmed
1706187
uniprot
proteins
pubmed
17170309
uniprot
proteins
pubmed
17925443
uniprot
proteins
pubmed
21719680
uniprot
proteins
pubmed
3203740
uniprot
proteins
pubmed
3768139
uniprot
proteins
pubmed
5150741
uniprot
proteins
pubmed
6153132
uniprot
proteins
pubmed
6326097
uniprot
proteins
pubmed
65791
uniprot
proteins
pubmed
7036996
uniprot
proteins
pubmed
7238864
uniprot
proteins
pubmed
891987
uniprot
proteins
pubmed
9523585
uniprot
proteins
sequence_length
125
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:65791}. Note=The precursor protein (pro-OXT) is packaged into neurosecretory granules. {ECO:0000269|PubMed:65791}.; SUBCELLULAR LOCATION: [Oxytocin]: Secreted {ECO:0000269|PubMed:65791}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:65791}. Note=Following processing, oxytocin and neurophysin 1 are transported to the posterior pituitary and stored in neurosecretory granules at the nerve termini until secreted. {ECO:0000269|PubMed:65791}.; SUBCELLULAR LOCATION: [Neurophysin 1]: Secreted {ECO:0000269|PubMed:65791}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:65791}. Note=Following processing, oxytocin and neurophysin 1 are transported to the posterior pituitary and stored in neurosecretory granules at the nerve termini until secreted. {ECO:0000269|PubMed:65791}.
uniprot
proteins