CNOT9
entrez
9125
canonical
uniprot
Q92600
canonical
ensembl
ENSG00000144580
resolver
ensp
ENSP00000273064
resolver
ensp
ENSP00000295701
resolver
ensp
ENSP00000486540
resolver
ensp
ENSP00000685401
resolver
genesymbol
CNOT9
resolver
genesymbol
RQCD1
resolver
genesymbol_syn
RCD1
resolver
genesymbol_syn
RQCD1
resolver
hgnc
HGNC:10445
resolver
uniprot
B2RPI0
resolver
uniprot
B5MDQ4
resolver
uniprot
B7Z1E5
resolver
uniprot
D5MQE1
resolver
uniprot
Q96IX4
resolver
uniprot_entry
CNOT9_HUMAN
resolver
uniprot_entry
D5MQE1_HUMAN
resolver
uniprot_sec
B2RPI0
resolver
uniprot_sec
B5MDQ4
resolver
uniprot_sec
B7Z1E5
resolver
uniprot_sec
Q96IX4
resolver
amino_acid_sequence
MHSLATAAPVPTTLAQVDREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVLKDDTTTKRWLAQLVKNLQEGQVTDPRGIPLPPQ
uniprot
proteins
function
FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. {ECO:0000250, ECO:0000269|PubMed:17189474, ECO:0000269|PubMed:18180299}.
uniprot
proteins
mass_dalton
33631
uniprot
proteins
mutagenesis
MUTAGEN 227; /note="R->E: Loss of DNA binding."; /evidence="ECO:0000269|PubMed:17189474
uniprot
proteins
protein_family
CNOT9 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17189474
uniprot
proteins
pubmed
18180299
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23232451
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9447985
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9JKY0}. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q9JKY0}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250|UniProtKB:Q9JKY0}.
uniprot
proteins