ANO10
entrez
55129
canonical
uniprot
Q9NW15
canonical
ensembl
ENSG00000160746
resolver
ensp
ENSP00000292246
resolver
ensp
ENSP00000327767
resolver
ensp
ENSP00000379398
resolver
ensp
ENSP00000394119
resolver
ensp
ENSP00000396990
resolver
ensp
ENSP00000580739
resolver
ensp
ENSP00000580744
resolver
ensp
ENSP00000590442
resolver
ensp
ENSP00000590449
resolver
ensp
ENSP00000640632
resolver
ensp
ENSP00000720177
resolver
ensp
ENSP00000720178
resolver
ensp
ENSP00000720179
resolver
ensp
ENSP00000720189
resolver
genesymbol
ANO10
resolver
genesymbol_syn
TMEM16K
resolver
hgnc
HGNC:25519
resolver
uniprot
A8K8K3
resolver
uniprot
A8MV74
resolver
uniprot
B3KTZ1
resolver
uniprot
B3KY93
resolver
uniprot
B4DJ83
resolver
uniprot
B4DNK2
resolver
uniprot
B7WP12
resolver
uniprot
C9JHS1
resolver
uniprot
Q8IXX9
resolver
uniprot_entry
ANO10_HUMAN
resolver
uniprot_sec
A8K8K3
resolver
uniprot_sec
A8MV74
resolver
uniprot_sec
B3KTZ1
resolver
uniprot_sec
B3KY93
resolver
uniprot_sec
B4DJ83
resolver
uniprot_sec
B4DNK2
resolver
uniprot_sec
B7WP12
resolver
uniprot_sec
C9JHS1
resolver
uniprot_sec
Q8IXX9
resolver
amino_acid_sequence
MKVTLSALDTSESSFTPLVVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLNKYEQETLENQNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDDNNDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFPLHDSEALKKLEDTWYTRFALKYQPIDSIRGYFGETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDYDKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFEEPRPGFHGVLGINSITGKEEPLYPSYKRQLRIYLVSLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLYVPSIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKDMKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQALKADIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMSPQVNAVFPESKADLILIVVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENLKEEPMESGKEKAT
uniprot
proteins
disease_involvement
DISEASE: Spinocerebellar ataxia, autosomal recessive, 10 (SCAR10) [MIM:613728]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR10 is characterized by onset in the teenage or young adult years of gait and limb ataxia, dysarthria, and nystagmus associated with marked cerebellar atrophy on brain imaging. {ECO:0000269|PubMed:21092923}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}.
uniprot
proteins
mass_dalton
76329
uniprot
proteins
protein_family
Anoctamin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
20056604
uniprot
proteins
pubmed
21092923
uniprot
proteins
pubmed
21607626
uniprot
proteins
pubmed
21642943
uniprot
proteins
pubmed
21984732
uniprot
proteins
pubmed
22075693
uniprot
proteins
pubmed
22302790
uniprot
proteins
pubmed
22946059
uniprot
proteins
sequence_length
660
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22075693, ECO:0000269|PubMed:22946059}; Multi-pass membrane protein {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22075693, ECO:0000269|PubMed:22946059}. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.
uniprot
proteins
transmembrane_region
TRANSMEM 208..228; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 317..337; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 353..373; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 401..421; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 501..521; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 554..574; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 591..611; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins