Tyw2
entrez
68260
canonical
uniprot
Q8BG71
canonical
ensembl
ENSMUSG00000037085
resolver
ensp
ENSMUSP00000047831
resolver
enst
ENSMUST00000036937
resolver
genesymbol
Tyw2
resolver
genesymbol_syn
Trmt12
resolver
uniprot
Q0P5W5
resolver
uniprot
Q7TNQ8
resolver
uniprot
Q9D2N1
resolver
uniprot_entry
TYW2_MOUSE
resolver
uniprot_sec
Q0P5W5
resolver
uniprot_sec
Q7TNQ8
resolver
uniprot_sec
Q9D2N1
resolver
amino_acid_sequence
MERECEESVVVAVVTEPRFTQRYRDYLEEQKLLDRLHRVAKLRDGAVALPVLAESLSEQHLQELRDRVAPGSTCVLTRLPDPLPSKKARVRSPAQILCLEVRRWVEDRGVTWSAELEADLPRSWQRHGDLMLLSEDCFQATLWKGLEPELWETVASALGVQRLAKRGRVLPDGTRTPSVTLLLGDHGWVEHMDNGIRYKFDVTQCMFSFGNITEKLRVASLSCAGEVLVDLYAGIGYFTLPFLVHAGAAFVHACEWNPHAVVALRNNLEINGVADRCQIHFGDNRKLKLSDIADRVNLGLIPSSKEGWPVACQVLRKDVGGILHIHQNVESFSGKTPQPPGSNNVEKEHWPRPQKITTDTQGNGTTENFRGEISSANKPEWWRWAESAETQIASLLHQVHGKPWRTRILHVHPVKSYAPHVDHIVLDLECRPLTSSWPEGVDLLTQ
uniprot
proteins
ec_number
2.5.1.114
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86. {ECO:0000250|UniProtKB:Q53H54}.
uniprot
proteins
mass_dalton
50299
uniprot
proteins
pathway_participation
PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis. {ECO:0000250|UniProtKB:Q53H54}.
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
TRM5/TYW2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
446
uniprot
proteins