SYT5
entrez
6861
canonical
uniprot
O00445
canonical
ensembl
ENSG00000129990
resolver
ensp
ENSP00000346265
resolver
ensp
ENSP00000465576
resolver
ensp
ENSP00000538739
resolver
ensp
ENSP00000538747
resolver
genesymbol
SYT5
resolver
hgnc
HGNC:11513
resolver
uniprot
B3KWJ8
resolver
uniprot
B7Z300
resolver
uniprot
Q4FD32
resolver
uniprot
Q86X72
resolver
uniprot_entry
Q4FD32_HUMAN
resolver
uniprot_entry
SYT5_HUMAN
resolver
uniprot_sec
B3KWJ8
resolver
uniprot_sec
B7Z300
resolver
uniprot_sec
Q86X72
resolver
amino_acid_sequence
MFPEPPTPGPPSPDTPPDSSRISHGPVPPWALATIVLVSGLLIFSCCFCLYRKSCRRRTGKKSQAQAQVHLQEVKGLGQSYIDKVQPEVEELEPAPSGPGQQVADKHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWRELQAAPREEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHWADMLANPRRPIAQWHSLRPPDRVRLLPAP
uniprot
proteins
function
FUNCTION: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
42900
uniprot
proteins
mutagenesis
MUTAGEN 202; /note="S->G: Does not affect Ca(2+) affinity as measured by isothermal titration calorimetry of the mutant protein."; /evidence="ECO:0000269|PubMed:27793683
uniprot
proteins
protein_family
Synaptotagmin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
27793683
uniprot
proteins
pubmed
9177789
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Recycling endosome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=In mast cells, localizes to the endocytic recycling compartment. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins