Ctu2
entrez
66965
canonical
uniprot
Q3U308
canonical
ensembl
ENSMUSG00000049482
resolver
ensp
ENSMUSP00000112113
resolver
enst
ENSMUST00000116412
resolver
genesymbol
Ctu2
resolver
genesymbol_syn
Ncs2
resolver
uniprot
Q8BTG9
resolver
uniprot
Q8CI68
resolver
uniprot_entry
CTU2_MOUSE
resolver
uniprot_sec
Q8BTG9
resolver
uniprot_sec
Q8CI68
resolver
amino_acid_sequence
MCQAGEDYAGPARREPPPVPRPSREQKCVKCAEGLPVVVIRAGDAFCRVCFKAFYVHKFRAMLGKNRVIFPGEKVLLSWSGGPSSSSMVWQVLEGLSQDSAKRLRFVPGVIYVDEGAACGQSLEDRQKTVAEVKRILENTGFPWHVVALEEVFSLPPSVLCCTSQESAGTEEAYKAAVDRFLQQQQQQQQRVLGAEAGASPAQGEARLHPSHGREPSGTAGYPTAAQTEALSRLFSSIKTLTAKEELLQTLRTHLIVHIARVHGYCKVMTGETCTRLAIKLMTNLALGRGAFLAWDTGFSDERHGDVVLVRPMRDHTLKEVAFYNHLFRVPSVFTPAIDTKAPEKASIHRLMEAFILRLQTLFPSTVSTVYRTSEKLVKAPREGCAAGPSGPSCLLCMCALDIDTADSATAFGAQSSSHLSQMPSAEAGMPTQPCCAAGEGQAQSCHREVGKRGDARACITEQLCYSCRVNMKDLPSLDPLPPYVLAEAQLRSQRGSVSEEIQEYLITDEEEDS
uniprot
proteins
function
FUNCTION: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255|HAMAP-Rule:MF_03054}.
uniprot
proteins
mass_dalton
56105
uniprot
proteins
pathway_participation
PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03054}.
uniprot
proteins
protein_family
CTU2/NCS2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03054}.
uniprot
proteins