Mgrn1
entrez
302938
canonical
uniprot
Q5XIQ4
canonical
ensembl
ENSRNOG00000003234
resolver
ensp
ENSRNOP00000004416
resolver
ensp
ENSRNOP00000077703
resolver
ensp
ENSRNOP00000095969
resolver
enst
ENSRNOT00000004416
resolver
enst
ENSRNOT00000095237
resolver
enst
ENSRNOT00000117920
resolver
genesymbol
Mgrn1
resolver
genesymbol_syn
mgrn1
resolver
uniprot
A0A8I5Y9P4
resolver
uniprot
A0A8I6AKW4
resolver
uniprot
A0A8L2Q0V6
resolver
uniprot
A0ACM8R3H7
resolver
uniprot
D3ZEH9
resolver
uniprot
G3C8Z1
resolver
uniprot_entry
A0A8I5Y9P4_RAT
resolver
uniprot_entry
A0A8L2Q0V6_RAT
resolver
uniprot_entry
A0ACM8R3H7_RAT
resolver
uniprot_entry
D3ZEH9_RAT
resolver
uniprot_entry
G3C8Z1_RAT
resolver
uniprot_entry
MGRN1_RAT
resolver
uniprot_sec
A0A8I6AKW4
resolver
amino_acid_sequence
MGSILSRRIAGVEDIDIQANSAYRYPPKSAGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDTDSPTEDGEKPRVLYSLEFTFDADARVAITIYCQAVEEFVNGMTVYSCKNPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHVDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSSECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPISFSPVLAQSVDHDEHSNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAGLDRIIENGIQKGKTQSKSPDSTLRSPSSPIHEEDEEKLSEDPEAPLPPSGVELVLQESSSPESFGTEEVGEPSLKQGSRVPSIDDVLQDGSPQHHGCSQPVPPADIYLPALGPESCSVGIEE
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Also acts as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9D074}.
uniprot
proteins
mass_dalton
58603
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated in vitro. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
533
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}. Early endosome {ECO:0000250}. Note=The endosomal localization is dependent on the interaction with TSG101. {ECO:0000250}.
uniprot
proteins