PARP12
entrez
64761
canonical
uniprot
Q9H0J9
canonical
ensembl
ENSG00000059378
resolver
ensp
ENSP00000263549
resolver
ensp
ENSP00000417730
resolver
ensp
ENSP00000521690
resolver
ensp
ENSP00000669777
resolver
ensp
ENSP00000669781
resolver
ensp
ENSP00000709721
resolver
ensp
ENSP00000779273
resolver
enst
ENST00000263549
resolver
enst
ENST00000473341
resolver
genesymbol
PARP12
resolver
genesymbol_syn
ZC3HDC1
resolver
hgnc
HGNC:21919
resolver
uniprot
G5E9U9
resolver
uniprot
Q9H610
resolver
uniprot
Q9NP36
resolver
uniprot
Q9NTI3
resolver
uniprot_entry
G5E9U9_HUMAN
resolver
uniprot_entry
PAR12_HUMAN
resolver
uniprot_sec
Q9H610
resolver
uniprot_sec
Q9NP36
resolver
uniprot_sec
Q9NTI3
resolver
amino_acid_sequence
MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLRQRGRFVVAVRAGGAAAAPERVVLAASPLRLCRAHQGSKPGCVGLCAQLHLCRFMVYGACKFLRAGKNCRNSHSLTTEHNLSVLRTHGVDHLSYNELCQLLFQNDPWLLPEICQHYNKGDGPHGSCAFQKQCIKLHICQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSDLVSRLPTIYRNAHDIKNKSSAPSRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLPYRWQFLDRGKWEDLDNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMTYGATQARRLSTASSVTKPPHFILTTDWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDVEKAYLAYCTPGSDGQAATLKFQAGKHNYELDFKAFVQKNLVYGTTKKVCRRPKYVSPQDVTTMQTCNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSIFVIFEKHQVYPEYVIQYTTSSKPSVTPSILLALGSLFSSRQ
uniprot
proteins
ec_number
2.4.2.-
uniprot
proteins
function
FUNCTION: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:34969853). Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication (PubMed:34187568). Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4 (PubMed:39888989). Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1 (PubMed:34969853). Acts also as a key regulator of mitochondrial function, protein translation, and inflammation. Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by up-regulating ISG15 and ISGylation (PubMed:39465252). {ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:34187568, ECO:0000269|PubMed:34969853, ECO:0000269|PubMed:39465252, ECO:0000269|PubMed:39888989}.
uniprot
proteins
mass_dalton
79064
uniprot
proteins
mutagenesis
MUTAGEN 564; /note="H->A: Catalytically inactive mutant."; /evidence="ECO:0000269|PubMed:29070863"; MUTAGEN 660; /note="I->A: Catalytically inactive mutant."; /evidence="ECO:0000269|PubMed:29070863
uniprot
proteins
post_translational_modification
PTM: Auto-mono-ADP-ribosylated. {ECO:0000269|PubMed:25043379}.; PTM: Phosphorylated by PRKD1. {ECO:0000269|PubMed:34969853}.
uniprot
proteins
protein_family
ARTD/PARP family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20106667
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25043379
uniprot
proteins
pubmed
25635049
uniprot
proteins
pubmed
29070863
uniprot
proteins
pubmed
34187568
uniprot
proteins
pubmed
34969853
uniprot
proteins
pubmed
39465252
uniprot
proteins
pubmed
39888989
uniprot
proteins
sequence_length
701
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:29070863, ECO:0000269|PubMed:39888989}. Cytoplasm, Stress granule {ECO:0000269|PubMed:29070863}. Note=Translocates from the Golgi complex to stress granules upon stress conditions. {ECO:0000269|PubMed:29070863}.
uniprot
proteins