Spc25
entrez
66442
canonical
uniprot
Q3UA16
canonical
ensembl
ENSMUSG00000005233
resolver
ensp
ENSMUSP00000005365
resolver
ensp
ENSMUSP00000107939
resolver
ensp
ENSMUSP00000128039
resolver
ensp
ENSMUSP00000278344
resolver
ensp
ENSMUSP00000349038
resolver
genesymbol
Spc25
resolver
genesymbol_syn
Spbc25
resolver
uniprot
Q9D021
resolver
uniprot
Q9D1K6
resolver
uniprot_entry
SPC25_MOUSE
resolver
uniprot_sec
Q9D021
resolver
uniprot_sec
Q9D1K6
resolver
amino_acid_sequence
MGEDELALLNQSINEFGDKFRNRLDDNHSQVLGLRDAFKDSMKAFSEKMSLKLKEEERMTEMILEYKNQLCKQNKLIQEKKENVLKMIAEVKGKEQESEELTAKIQELKEEYARKRETISTANKANEERLKGLQKSADLYRDYLGLEIRKIHGNKLQFIFTSIDPKNPESPYMFSMSINEAKEYEVYDSSPHLECLAEFQEKVRKTNNFSAFLANIRKAFIAKVHN
uniprot
proteins
function
FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. {ECO:0000250|UniProtKB:Q9HBM1}.
uniprot
proteins
mass_dalton
26457
uniprot
proteins
protein_family
SPC25 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9HBM1}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9HBM1}. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. {ECO:0000250|UniProtKB:Q9HBM1}.
uniprot
proteins