Cacna2d2
entrez
56808
canonical
uniprot
Q6PHS9
canonical
ensembl
ENSMUSG00000010066
resolver
ensp
ENSMUSP00000010210
resolver
ensp
ENSMUSP00000082173
resolver
ensp
ENSMUSP00000125943
resolver
ensp
ENSMUSP00000126029
resolver
ensp
ENSMUSP00000132512
resolver
ensp
ENSMUSP00000168112
resolver
ensp
ENSMUSP00000168113
resolver
genesymbol
Cacna2d2
resolver
genesymbol_syn
Kiaa0558
resolver
uniprot
A0A411ACW5
resolver
uniprot
A0A411ACX9
resolver
uniprot
A0A411ACZ2
resolver
uniprot
B2RY16
resolver
uniprot
Q3TPT9
resolver
uniprot
Q3TSS6
resolver
uniprot
Q6REE3
resolver
uniprot
Q8C8R8
resolver
uniprot
Q8CHE9
resolver
uniprot
Q920H5
resolver
uniprot
Q920H6
resolver
uniprot
Q9EQG2
resolver
uniprot
Q9R142
resolver
uniprot_entry
A0A411ACW5_MOUSE
resolver
uniprot_entry
A0A411ACX9_MOUSE
resolver
uniprot_entry
A0A411ACZ2_MOUSE
resolver
uniprot_entry
CA2D2_MOUSE
resolver
uniprot_sec
B2RY16
resolver
uniprot_sec
Q3TPT9
resolver
uniprot_sec
Q3TSS6
resolver
uniprot_sec
Q6REE3
resolver
uniprot_sec
Q8C8R8
resolver
uniprot_sec
Q8CHE9
resolver
uniprot_sec
Q920H5
resolver
uniprot_sec
Q920H6
resolver
uniprot_sec
Q9EQG2
resolver
uniprot_sec
Q9R142
resolver
amino_acid_sequence
MAVPARTCGASWPGPVRTARPWPGRGPRPCPDPRGPASGPARPLLLLLPPLLLLPLLTAPGASAYSFPQQHTMQHWARRLEQEIDGVMRIFGGVQQLREIYKDNRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEDPNFKNKVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTHLVQANVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITRANCNKMIMMFTDGGEDRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKDAKQVQWTNVYEDALGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMIDGDKGHKQIRTLVKSLDERYIDEVIRNYTWVPIRSTNYSLGLVLPPYSTYYLQANLSDQILQVKLPISKLKDFEFLLPSSFESEGHVFIAPREYCKDLNASDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEPFNASFYRRSLDNHGYIFKPPHQDSLLRPLELENDTVGVLVSTAVELSLGRRTLRPAVVGVKLDLEAWAEKFKVLASNRTHQDQPQKCGPSSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTIADFLNLAWWTSAAAWSLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYFGSVNASYNAIIDCGNCSRLFHAQRLTNTNLLFVVAEKPLCSQCEAGRLLQKETHSDGPEQCELVQRPRYRRGPHICFDYNATEDTSDCGRGASFPPSLGVLVSLQLLLLLGLPPRPQPQVHSFAASRHL
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Cacna2d2 are the cause of ducky phenotype (du). Du mice have spike-wave seizures characteristic of absence epilepsy and ataxia, with accompanying decreased calcium channel current in cerebellar Purkinje cells. {ECO:0000269|PubMed:11487633, ECO:0000269|PubMed:11756448, ECO:0000269|PubMed:14660671, ECO:0000269|PubMed:17135419}.
uniprot
proteins
function
FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). {ECO:0000269|PubMed:15331424}.
uniprot
proteins
mass_dalton
130385
uniprot
proteins
mutagenesis
MUTAGEN 282; /note="R->A: Induces a strong decrease in gabapentin-binding."; /evidence="ECO:0000269|PubMed:16928863"; MUTAGEN 300; /note="D->A: Abolishes metal-binding and ability to regulate calcium current."; /evidence="ECO:0000269|PubMed:16061813"; MUTAGEN 302; /note="S->A: Abolishes metal-binding and ability to regulate calcium current."; /evidence="ECO:0000269|PubMed:16061813"; MUTAGEN 304; /note="S->A: Abolishes metal-binding and ability to regulate calcium current."; /evidence="ECO:0000269|PubMed:16061813
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:11306709, ECO:0000269|PubMed:17052222}.; PTM: May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role. According to PubMed:11306709, it is processed, at least in vitro, while according to PubMed:17052222, it is only poorly processed in vivo. {ECO:0000269|PubMed:11306709}.
uniprot
proteins
protein_family
Calcium channel subunit alpha-2/delta family
uniprot
proteins
pubmed
10762351
uniprot
proteins
pubmed
10766861
uniprot
proteins
pubmed
11130987
uniprot
proteins
pubmed
11306709
uniprot
proteins
pubmed
11487633
uniprot
proteins
pubmed
11756448
uniprot
proteins
pubmed
12465718
uniprot
proteins
pubmed
14660671
uniprot
proteins
pubmed
15331424
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16061813
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16928863
uniprot
proteins
pubmed
17052222
uniprot
proteins
pubmed
17135419
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1154
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with CACNA1A in lipid raft fractions. {ECO:0000269|PubMed:11756448, ECO:0000269|PubMed:16928863}.
uniprot
proteins
transmembrane_region
TRANSMEM 1117..1137; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins