Septin2
entrez
18000
canonical
uniprot
P42208
canonical
ensembl
ENSMUSG00000026276
resolver
ensp
ENSMUSP00000027495
resolver
ensp
ENSMUSP00000262614
resolver
ensp
ENSMUSP00000262624
resolver
ensp
ENSMUSP00000326950
resolver
ensp
ENSMUSP00000326951
resolver
ensp
ENSMUSP00000326954
resolver
enst
ENSMUST00000027495
resolver
genesymbol
Septin2
resolver
genesymbol_syn
Nedd5
resolver
genesymbol_syn
Sept2
resolver
uniprot
B2RRZ2
resolver
uniprot
Q3U9Y5
resolver
uniprot_entry
SEPT2_MOUSE
resolver
uniprot_sec
B2RRZ2
resolver
uniprot_sec
Q3U9Y5
resolver
amino_acid_sequence
MSKQQPTQFINPETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLINSLFLTDLYPERIIPGAAEKIERTVQIEASTVEIEERGVKLRLTVVDTPGYGDAINCRDCFKTIISYIDEQFERYLHDESGLNRRHIIDNRVHCCFYFISPFGHGLKPLDVAFMKAIHNKVNIVPVIAKADTLTLKERERLKKRILDEIEEHSIKIYHLPDAESDEDEDFKEQTRLLKASIPFSVVGSNQLIEAKGKKVRGRLYPWGVVEVENPEHNDFLKLRTMLITHMQDLQEVTQDLHYENFRSERLKRGGRKVENEDMNKDQILLEKEAELRRMQEMIARMQAQMQMQMQGGDSDSGALGQHV
uniprot
proteins
function
FUNCTION: Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements (By similarity). In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. {ECO:0000250, ECO:0000250|UniProtKB:Q15019, ECO:0000269|PubMed:20558667, ECO:0000269|PubMed:22179047, ECO:0000269|PubMed:9203580}.
uniprot
proteins
mass_dalton
41526
uniprot
proteins
mutagenesis
MUTAGEN 46; /note="S->D: Loss of GTP-binding."; /evidence="ECO:0000269|PubMed:19805342"; MUTAGEN 47; /note="G->V: Loss of GTP-binding activity."; /evidence="ECO:0000269|PubMed:9203580"; MUTAGEN 51; /note="S->N: Loss of GTP-binding activity."; /evidence="ECO:0000269|PubMed:9203580"; MUTAGEN 78; /note="T->G: Reduces affinity for GTP 20-fold."; /evidence="ECO:0000269|PubMed:19805342"; MUTAGEN 125; /note="Q->L: Loss of GTP-binding activity."; /evidence="ECO:0000269|PubMed:9203580
uniprot
proteins
protein_family
Septin GTPase family
uniprot
proteins
protein_family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily
uniprot
proteins
pubmed
11739749
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19805342
uniprot
proteins
pubmed
20558667
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22179047
uniprot
proteins
pubmed
25588830
uniprot
proteins
pubmed
38870534
uniprot
proteins
pubmed
9203580
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, cilium membrane. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q15019}. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle (By similarity). In interphase and postmitotic cells, localized to fibrous or granular structures, depending on the growth state of the cell. Localizes at the base of the cilia near the morphological distinction between the cilia and plasma membranes. Expressed in the sperm annulus, neck and tail. {ECO:0000250, ECO:0000250|UniProtKB:Q15019, ECO:0000269|PubMed:25588830, ECO:0000269|PubMed:38870534}.
uniprot
proteins