IRF2
entrez
3660
canonical
uniprot
P14316
canonical
ensembl
ENSG00000168310
resolver
ensp
ENSP00000377218
resolver
genesymbol
IRF2
resolver
hgnc
HGNC:6117
resolver
uniprot
D6RCK5
resolver
uniprot
H0Y8S3
resolver
uniprot
Q6IAS7
resolver
uniprot
Q96B99
resolver
uniprot_entry
IRF2_HUMAN
resolver
uniprot_sec
D6RCK5
resolver
uniprot_sec
H0Y8S3
resolver
uniprot_sec
Q6IAS7
resolver
uniprot_sec
Q96B99
resolver
amino_acid_sequence
MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAIHTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLPLSERPSKKGKKPKTEKEDKVKHIKQEPVESSLGLSNGVSDLSPEYAVLTSTIKNEVDSTVNIIVVGQSHLDSNIENQEIVTNPPDICQVVEVTTESDEQPVSMSELYPLQISPVSSYAESETTDSVPSDEESAEGRPHWRKRNIEGKQYLSNMGTRGSYLLPGMASFVTSNKPDLQVTIKEESNPVPYNSSWPPFQDLPLSSSMTPASSSSRPDRETRASVIKKTSDITQARVKSC
uniprot
proteins
function
FUNCTION: DNA-binding transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible genes and regulates their expression (PubMed:39013473, PubMed:7687740). Mainly acts as a transcription repressor, repressing expression (PubMed:39013473). Also acts as an activator for several genes including H4 and IL7 (PubMed:15226432, PubMed:9540062). Constitutively binds to the ISRE promoter to activate IL7 (PubMed:15226432). Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth (PubMed:9540062). Antagonizes IRF1 transcriptional activation (By similarity). {ECO:0000250|UniProtKB:P23906, ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:39013473, ECO:0000269|PubMed:7687740, ECO:0000269|PubMed:9540062}.; FUNCTION: [Isoform 2]: Unable to bind to IRF2BP1 and IRF2BP2 corepressors and cannot mediate repression. {ECO:0000269|PubMed:12799427}.
uniprot
proteins
mass_dalton
39354
uniprot
proteins
mutagenesis
MUTAGEN 75; /note="K->R: Diminished acetylation by both CREBBP/p300 and PCAF. Greatly reduced enhancement of H4 promoter activity."; /evidence="ECO:0000269|PubMed:12738767"; MUTAGEN 78; /note="K->R: Greatly diminished acetylation by PCAF. Lesser loss of acetylation by CREBBP/p300. Loss of DNA binding and no enhancement of H4 promoter activity."; /evidence="ECO:0000269|PubMed:12738767"; MUTAGEN 137; /note="K->R: Some loss of sumoylation. Increases IRF2-mediation activation of ISRE and H4 promoters. Increased inhibition of IRF1-mediated transcription. Additional small loss of sumoylation; when associated with R-166. Great loss of sumoylation; when associated with R-296. Abolishes sumoylation. Greatly increased activation of ISRE and H4 promoters and further increased ability to inhibit IRF1-mediated transcription; when associated with R-166 and R-293."; /evidence="ECO:0000269|PubMed:18514056"; MUTAGEN 166; /note="K->R: Little loss of sumoylation. Increases IRF2-mediation activation of ISRE and H4 promoters. Increased inhibition of IRF1-mediated transcription. Greater loss of sumoylation; when associated with R-137. Further loss of sumoylation; when associated with R-293. Abolishes sumoylation. Greatly increased activation of ISRE and H4 promoters and further increased ability to inhibit IRF1-mediated transcription; when associated with R-137 and R-293."; /evidence="ECO:0000269|PubMed:18514056"; MUTAGEN 293; /note="K->R: Some loss of sumoylation. Increases IRF2-mediation activation of ISRE and H4 promoters. Increased inhibition of IRF1-mediated transcription. Further small loss of sumoylation; when associated with R-166. Great loss of sumoylation; when associated with R-137. Abolishes sumoylation. Greatly increased activation of ISRE and H4 promoters and further increased ability to inhibit IRF1-mediated transcription; when associated with R-166 and R-293."; /evidence="ECO:0000269|PubMed:18514056
uniprot
proteins
post_translational_modification
PTM: Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity. {ECO:0000269|PubMed:12738767}.; PTM: The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter. {ECO:0000269|PubMed:18514056}.
uniprot
proteins
protein_family
IRF family
uniprot
proteins
pubmed
11025449
uniprot
proteins
pubmed
11058120
uniprot
proteins
pubmed
12738767
uniprot
proteins
pubmed
12799427
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15226432
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18514056
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
2813069
uniprot
proteins
pubmed
39013473
uniprot
proteins
pubmed
39489739
uniprot
proteins
pubmed
7507207
uniprot
proteins
pubmed
7687740
uniprot
proteins
pubmed
8106512
uniprot
proteins
pubmed
9540062
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P23906}. Chromosome {ECO:0000250|UniProtKB:P23906}.
uniprot
proteins