SLC15A3
entrez
51296
canonical
uniprot
Q8IY34
canonical
ensembl
ENSG00000110446
resolver
ensp
ENSP00000227880
resolver
ensp
ENSP00000505077
resolver
enst
ENST00000227880
resolver
enst
ENST00000681275
resolver
genesymbol
SLC15A3
resolver
genesymbol_syn
OCTP
resolver
genesymbol_syn
PHT2
resolver
genesymbol_syn
PTR3
resolver
hgnc
HGNC:18068
resolver
uniprot
A0A7P0T8H0
resolver
uniprot
Q9P2X9
resolver
uniprot_entry
A0A7P0T8H0_HUMAN
resolver
uniprot_entry
S15A3_HUMAN
resolver
uniprot_sec
Q9P2X9
resolver
amino_acid_sequence
MPAPRAREQPRVPGERQPLLPRGARGPRRWRRAAGAAVLLVEMLERAAFFGVTANLVLYLNSTNFNWTGEQATRAALVFLGASYLLAPVGGWLADVYLGRYRAVALSLLLYLAASGLLPATAFPDGRSSFCGEMPASPLGPACPSAGCPRSSPSPYCAPVLYAGLLLLGLAASSVRSNLTSFGADQVMDLGRDATRRFFNWFYWSINLGAVLSLLVVAFIQQNISFLLGYSIPVGCVGLAFFIFLFATPVFITKPPMGSQVSSMLKLALQNCCPQLWQRHSARDRQCARVLADERSPQPGASPQEDIANFQVLVKILPVMVTLVPYWMVYFQMQSTYVLQGLHLHIPNIFPANPANISVALRAQGSSYTIPEAWLLLANVVVVLILVPLKDRLIDPLLLRCKLLPSALQKMALGMFFGFTSVIVAGVLEMERLHYIHHNETVSQQIGEVLYNAAPLSIWWQIPQYLLIGISEIFASIPGLEFAYSEAPRSMQGAIMGIFFCLSGVGSLLGSSLVALLSLPGGWLHCPKDFGNINNCRMDLYFFLLAGIQAVTALLFVWIAGRYERASQGPASHSRFSRDRG
uniprot
proteins
function
FUNCTION: Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (PubMed:39719710). Preferably binds to short peptides with a basic residue at the first position and a hydrophobic residue at the second position (PubMed:39719710). Also able to transport carnosine (PubMed:31073693, PubMed:31254495). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity). {ECO:0000250|UniProtKB:Q8BPX9, ECO:0000269|PubMed:31073693, ECO:0000269|PubMed:31254495, ECO:0000269|PubMed:39719710}.
uniprot
proteins
mass_dalton
63560
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17897319
uniprot
proteins
pubmed
31073693
uniprot
proteins
pubmed
31254495
uniprot
proteins
pubmed
39719710
uniprot
proteins
sequence_length
581
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000269|PubMed:39719710}. Endosome membrane {ECO:0000250|UniProtKB:Q8BPX9}; Multi-pass membrane protein {ECO:0000269|PubMed:39719710}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..56; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX2, ECO:0007744|PDB:8ZAT"; TRANSMEM 75..90; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX2, ECO:0007744|PDB:8ZAT"; TRANSMEM 103..118; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX2, ECO:0007744|PDB:8ZAT"; TRANSMEM 160..175; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX2, ECO:0007744|PDB:8ZAT"; TRANSMEM 201..220; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX2, ECO:0007744|PDB:8ZAT"; TRANSMEM 227..247; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX2, ECO:0007744|PDB:8ZAT"; TRANSMEM 316..334; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX2, ECO:0007744|PDB:8ZAT"; TRANSMEM 373..387; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX2, ECO:0007744|PDB:8ZAT"; TRANSMEM 411..427; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX2, ECO:0007744|PDB:8ZAT"; TRANSMEM 465..475; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX2, ECO:0007744|PDB:8ZAT"; TRANSMEM 498..517; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX2, ECO:0007744|PDB:8ZAT"; TRANSMEM 540..560; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX2, ECO:0007744|PDB:8ZAT
uniprot
proteins