RNF123
entrez
63891
canonical
uniprot
Q5XPI4
canonical
ensembl
ENSG00000164068
resolver
ensp
ENSP00000328287
resolver
genesymbol
RNF123
resolver
genesymbol_syn
KPC1
resolver
hgnc
HGNC:21148
resolver
uniprot
A1L4Q3
resolver
uniprot
A6NLS5
resolver
uniprot
Q5I022
resolver
uniprot
Q6PFW4
resolver
uniprot
Q71RH0
resolver
uniprot
Q8IW18
resolver
uniprot
Q9H0M8
resolver
uniprot
Q9H5L8
resolver
uniprot
Q9H9T2
resolver
uniprot_entry
RN123_HUMAN
resolver
uniprot_sec
A1L4Q3
resolver
uniprot_sec
A6NLS5
resolver
uniprot_sec
Q5I022
resolver
uniprot_sec
Q6PFW4
resolver
uniprot_sec
Q71RH0
resolver
uniprot_sec
Q8IW18
resolver
uniprot_sec
Q9H0M8
resolver
uniprot_sec
Q9H5L8
resolver
uniprot_sec
Q9H9T2
resolver
amino_acid_sequence
MASKGAGMSFSRKSYRLTSDAEKSRVTGIVQEKLLNDYLNRIFSSSEHAPPAATSRKPLNFQNLPEHLDQLLQVDNEEEESQGQVEGRLGPSTVVLDHTGGFEGLLLVDDDLLGVIGHSNFGTIRSTTCVYKGKWLYEVLISSQGLMQIGWCTISCRFNQEEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSLGTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGYRPLQDPPSADLVRAQRLLGCFRAVLSVELDPVEGRLLDKESSKWRLRGQPTVLLTLAHIFHHFAPLLRKVYLVEAVLMSFLLGIVEKGTPTQAQSVVHQVLDLLWLFMEDYEVQDCLKQLMMSLLRLYRFSPIVPDLGLQIHYLRLTIAILRHEKSRKFLLSNVLFDVLRSVVFFYIKSPLRVEEAGLQELIPTTWWPHCSSREGKESTEMKEETAEERLRRRAYERGCQRLRKRIEVVEELQVQILKLLLDNKDDNGGEASRYIFLTKFRKFLQENASGRGNMPMLCPPEYMVCFLHRLISALRYYWDEYKASNPHASFSEEAYIPPQVFYNGKVDYFDLQRLGGLLSHLRKTLKDDLASKANIVIDPLELQSTAMDDLDEDEEPAPAMAQRPMQALAVGGPLPLPRPGWLSSPTLGRANRFLSTAAVSLMTPRRPLSTSEKVKVRTLSVEQRTREDIEGSHWNEGLLLGRPPEEPEQPLTENSLLEVLDGAVMMYNLSVHQQLGKMVGVSDDVNEYAMALRDTEDKLRRCPKRRKDILAELTKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLRTIEHGDRTGSLFAFMPEFYLSVAINSYSALKNYFGPVHSMEELPGYEETLTRLAAILAKHFADARIVGTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQTNWILVRLWRGCGFGYRYTRLPHLLKTKLEDANLPSLQKPCPSTLLQQHMADLLQQGPDVAPSFLNSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLLRVLEMTITLVPEIFLDWTRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGLESVDHYPILVAVTGILVQLLVRGPASEREQATSVLLADPCFQLRSICYLLGQPEPPAPGTALPAPDRKRFSLQSYADYISADELAQVEQMLAHLTSASAQAAAASLPTSEEDLCPICYAHPISAVFQPCGHKSCKACINQHLMNNKDCFFCKTTIVSVEDWEKGANTSTTSSAA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase (PubMed:15531880, PubMed:16227581, PubMed:25860612). Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle (PubMed:15531880, PubMed:16227581). Also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B: acts by catalyzing ubiquitination of the NFKB1 p105 precursor, leading to limited proteasomal degradation of NFKB1 p105 and generation of the active NFKB1 p50 subunit (PubMed:25860612, PubMed:33168738, PubMed:34873064). Also functions as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity (PubMed:27312109). Interacts with the N-terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS (PubMed:27312109). {ECO:0000269|PubMed:15531880, ECO:0000269|PubMed:16227581, ECO:0000269|PubMed:25860612, ECO:0000269|PubMed:27312109, ECO:0000269|PubMed:33168738, ECO:0000269|PubMed:34873064}.
uniprot
proteins
mass_dalton
148515
uniprot
proteins
mutagenesis
MUTAGEN 968..974; /note="Missing: Abolished ability to bind and ubiquitinate NFKB1."; /evidence="ECO:0000269|PubMed:34873064"; MUTAGEN 1256; /note="I->A: Abolished E3 ubiquitin-protein ligase activity and ability to promote maturation of the NFKB1 component of NF-kappa-B."; /evidence="ECO:0000269|PubMed:25860612
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:15531880, ECO:0000269|PubMed:16227581, ECO:0000269|PubMed:25860612, ECO:0000269|PubMed:33168738, ECO:0000269|PubMed:34873064}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation. Deubiquitinated by USP19, thereby stimulating CDKN1B ubiquitin-dependent degradation. {ECO:0000250|UniProtKB:D3ZXK7}.
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
15531880
uniprot
proteins
pubmed
16227581
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25860612
uniprot
proteins
pubmed
27312109
uniprot
proteins
pubmed
33168738
uniprot
proteins
pubmed
34873064
uniprot
proteins
sequence_length
1314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15531880, ECO:0000269|PubMed:27312109}.
uniprot
proteins