Cxcr4
entrez
60628
canonical
uniprot
O08565
canonical
ensembl
ENSRNOG00000003866
resolver
ensembl
ENSRNOG00055020692
resolver
ensembl
ENSRNOG00060018809
resolver
ensembl
ENSRNOG00065009543
resolver
ensp
ENSRNOP00000005143
resolver
ensp
ENSRNOP00055028633
resolver
ensp
ENSRNOP00060026438
resolver
ensp
ENSRNOP00065011475
resolver
enst
ENSRNOT00000005143
resolver
enst
ENSRNOT00055035326
resolver
enst
ENSRNOT00060032428
resolver
enst
ENSRNOT00065015277
resolver
genesymbol
Cxcr4
resolver
genesymbol_syn
Cmkar4
resolver
uniprot
F1LPN8
resolver
uniprot
Q8VD47
resolver
uniprot_entry
CXCR4_RAT
resolver
uniprot_sec
F1LPN8
resolver
uniprot_sec
Q8VD47
resolver
amino_acid_sequence
MEIYTSDNYSEEVGSGDYDSNKEPCFRDENENFNRIFLPTIYFIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAMADWYFGKFLCKAVHIIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKAVYVGVWIPALLLTIPDIIFADVSQGDGRYICDRLYPDSLWMVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYVGISIDSFILLEVIKQGCEFESVVHKWISITEALAFFHCCLNPILYAFLGAKFKSSAQHALNSMSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
uniprot
proteins
function
FUNCTION: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. CXCR4 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Also acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development; in the CNS, could mediate hippocampal-neuron surviva (By similarity). {ECO:0000250|UniProtKB:P61073, ECO:0000250|UniProtKB:P70658}.
uniprot
proteins
mass_dalton
39429
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on agonist stimulation. Phosphorylation of the P-X-P-P motif promotes association with beta-arrestin ARRB1, leading to receptor desensitization and negative regulation of G protein-coupled receptor signaling. Phosphorylation at Ser-321 and Ser-322 leads to recruitment of ITCH, ubiquitination and protein degradation. {ECO:0000250|UniProtKB:P61073}.; PTM: Ubiquitinated after ligand binding, leading to its degradation. Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S. {ECO:0000250|UniProtKB:P61073}.; PTM: Sulfation is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization. {ECO:0000250|UniProtKB:P61073}.; PTM: O- and N-glycosylated. N-glycosylation can mask coreceptor function. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity. {ECO:0000250|UniProtKB:P61073}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P61073}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P61073}. Cell junction {ECO:0000250|UniProtKB:P61073}. Early endosome {ECO:0000250|UniProtKB:P61073}. Late endosome {ECO:0000250|UniProtKB:P61073}. Lysosome {ECO:0000250|UniProtKB:P61073}. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC). {ECO:0000250|UniProtKB:P61073}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..60; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P61073"; TRANSMEM 75..96; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P61073"; TRANSMEM 108..127; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P61073"; TRANSMEM 152..171; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P61073"; TRANSMEM 193..213; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P61073"; TRANSMEM 239..258; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P61073"; TRANSMEM 280..299; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P61073
uniprot
proteins