Rab4a
entrez
25532
canonical
uniprot
P05714
canonical
ensembl
ENSRNOG00000017467
resolver
ensembl
ENSRNOG00055021792
resolver
ensembl
ENSRNOG00060017180
resolver
ensembl
ENSRNOG00065018949
resolver
ensp
ENSRNOP00000048878
resolver
ensp
ENSRNOP00055030466
resolver
ensp
ENSRNOP00060023714
resolver
ensp
ENSRNOP00065025441
resolver
enst
ENSRNOT00000049337
resolver
enst
ENSRNOT00055037382
resolver
enst
ENSRNOT00060029495
resolver
enst
ENSRNOT00065031884
resolver
genesymbol
Rab4a
resolver
genesymbol_syn
Rab4
resolver
uniprot
Q6P6U4
resolver
uniprot_entry
RAB4A_RAT
resolver
uniprot_sec
Q6P6U4
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MAQTAMSETYDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGSKIINVGGKYVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNALTNWLTDARMLASQNIVIILCGNKKDLDADREVTFLEASRFAQENELMFLETSALTGENVEEAFMQCARKILNKIESGELDPERMGSGIQYGDAALRQLRSPRRTQAPSAQECGC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB4A is involved in protein transport. Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). {ECO:0000250|UniProtKB:P20338, ECO:0000250|UniProtKB:P56371}.
uniprot
proteins
mass_dalton
24409
uniprot
proteins
post_translational_modification
PTM: Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity. {ECO:0000250|UniProtKB:P56371}.; PTM: Phosphorylated by CDK1 kinase during mitosis. {ECO:0000250|UniProtKB:P20338}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20098723
uniprot
proteins
pubmed
3344209
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P20338}; Peripheral membrane protein {ECO:0000250|UniProtKB:P20338}. Cytoplasm {ECO:0000250|UniProtKB:P20338}. Early endosome membrane {ECO:0000269|PubMed:20098723}; Peripheral membrane protein {ECO:0000305}. Recycling endosome membrane {ECO:0000269|PubMed:20098723}; Peripheral membrane protein {ECO:0000305}. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1. {ECO:0000250|UniProtKB:P20338}.
uniprot
proteins