Got2
entrez
14719
canonical
uniprot
P05202
canonical
ensembl
ENSMUSG00000031672
resolver
ensp
ENSMUSP00000034097
resolver
enst
ENSMUST00000034097
resolver
genesymbol
Got2
resolver
genesymbol_syn
Got-2
resolver
uniprot
O09188
resolver
uniprot
Q3TIP6
resolver
uniprot
Q3UD91
resolver
uniprot
Q5HZH5
resolver
uniprot_entry
AATM_MOUSE
resolver
uniprot_sec
O09188
resolver
uniprot_sec
Q3TIP6
resolver
uniprot_sec
Q3UD91
resolver
uniprot_sec
Q5HZH5
resolver
amino_acid_sequence
MALLHSSRILSGMAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENNEVLKSGRFVTVQTISGTGALRVGASFLQRFFKFSRDVFLPKPSWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFSGALEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIASVVKKKNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLNGARIAATILTSPDLRKQWLQEVKGMADRIISMRTQLVSNLKKEGSSHNWQHITDQIGMFCFTGLKPEQVERLTKEFSVYMTKDGRISVAGVTSGNVGYLAHAIHQVTK
uniprot
proteins
ec_number
2.6.1.1
uniprot
proteins
ec_number
2.6.1.7
uniprot
proteins
function
FUNCTION: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:20977429, ECO:0000269|PubMed:7878064}.
uniprot
proteins
mass_dalton
47411
uniprot
proteins
mutagenesis
MUTAGEN 209; /note="Missing: Heterozygous mice are viable and healthy. Results in early lethality at homozygosity."; /evidence="ECO:0000269|PubMed:31422819"; MUTAGEN 337; /note="R->G: Heterozygous mice are viable and healthy. Results in early lethality at homozygosity."; /evidence="ECO:0000269|PubMed:31422819
uniprot
proteins
post_translational_modification
PTM: Acetylation of Lys-296, Lys-345 and Lys-363 is observed in liver mitochondria from fasted mice but not from fed mice.
uniprot
proteins
protein_family
Class-I pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
10642497
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16800626
uniprot
proteins
pubmed
17442055
uniprot
proteins
pubmed
19826765
uniprot
proteins
pubmed
20977429
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
2828632
uniprot
proteins
pubmed
31422819
uniprot
proteins
pubmed
3782150
uniprot
proteins
pubmed
7878064
uniprot
proteins
sequence_length
430
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix. Cell membrane {ECO:0000269|PubMed:7878064}.
uniprot
proteins