NOX1
entrez
27035
canonical
uniprot
Q9Y5S8
canonical
ensembl
ENSG00000007952
resolver
ensp
ENSP00000217885
resolver
ensp
ENSP00000362051
resolver
ensp
ENSP00000362057
resolver
enst
ENST00000372960
resolver
genesymbol
NOX1
resolver
genesymbol_syn
MOX1
resolver
genesymbol_syn
NOH1
resolver
hgnc
HGNC:7889
resolver
uniprot
A6NGA6
resolver
uniprot
A8K836
resolver
uniprot
O95691
resolver
uniprot
Q1ZYL4
resolver
uniprot
Q2PP02
resolver
uniprot_entry
A6NGA6_HUMAN
resolver
uniprot_entry
NOX1_HUMAN
resolver
uniprot_entry
Q1ZYL4_HUMAN
resolver
uniprot_sec
A8K836
resolver
uniprot_sec
O95691
resolver
uniprot_sec
Q2PP02
resolver
activity_regulation
ACTIVITY REGULATION: The oxidase activity is potentiated by NOXA1, NOXO1 and RAC1. {ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:16329988, ECO:0000269|PubMed:16636067}.
uniprot
proteins
amino_acid_sequence
MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in NOX1 may play a role in the pathogenesis of very early onset inflammatory bowel disease (VEOIBD), a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology diagnosed before 6 years of age. VEOIBD is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but the phenotype of children with onset of Crohn disease occurring younger than the age of 10 is predominantly colonic, with a lower risk of ileal disease. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269|PubMed:26301257}.
uniprot
proteins
ec_number
1.6.3.-
uniprot
proteins
function
FUNCTION: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. {ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:16329988, ECO:0000269|PubMed:16636067, ECO:0000269|PubMed:19755710}.; FUNCTION: [Isoform NOH-1L]: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. {ECO:0000269|PubMed:10485709}.
uniprot
proteins
mass_dalton
64871
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-430 mediated by PKC/PRKBC positively regulates its interaction with NOXA1 and enzyme activity. {ECO:0000250|UniProtKB:Q9WV87}.
uniprot
proteins
pubmed
10485709
uniprot
proteins
pubmed
10615049
uniprot
proteins
pubmed
14617635
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16329988
uniprot
proteins
pubmed
16636067
uniprot
proteins
pubmed
19755710
uniprot
proteins
pubmed
24365146
uniprot
proteins
pubmed
26301257
uniprot
proteins
sequence_length
564
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, invadopodium membrane {ECO:0000269|PubMed:19755710}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:26301257}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 45..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 397..417; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins