Arfgap2
entrez
362162
canonical
uniprot
Q3MID3
canonical
ensembl
ENSRNOG00000014429
resolver
ensp
ENSRNOP00000053988
resolver
ensp
ENSRNOP00000088256
resolver
enst
ENSRNOT00000057161
resolver
genesymbol
Arfgap2
resolver
genesymbol_syn
Zfp289
resolver
genesymbol_syn
Znf289
resolver
uniprot_entry
ARFG2_RAT
resolver
amino_acid_sequence
MAAGPSKSEIQTLFKRLRAIPTNKACFDCGAKSPSWASITYGVFLCIDCSGVHRSLGVHLSFIRSTELDSNWSWLQLRCMQVGGNANATAFFRQHGCLANDANTKYNSRAAQMYREKIRQLGSTALARHGTDLWIDNMNSAPSHSPEKKDSDFFTEHTQAPAWDTAATDPSGTQQPALPSESSSLAQPEPGPNTDLLGTSPQASLELKSSIIGKKKPAAAKKGLGAKKGLGAQKVSNQSFTEIERQAQVAEKLREQQAADAKKQAEESMVASMRLAYQELQIDRKKEEKKLQNLEGKKREQAERLGMGLVSRSSISHSVLSEMQMIEQETPLSAKSSRSQLDLFDDVGTFASGPPKYKDNPFSLGETFGSRWDSDAAWGMDRVEEKEPEVTISSIRPISERTTSRREVESRISGLESSEARQKFAGAKAISSDMFFGREVDSEYEARSRLQQLSGSSAISSSDLFGDVDGAHGGGTVSLGNVLPTADIAQFKQGVKSVAGKMAVLANGVMNSLQDRYGSY
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1), which is essential for COPI vesicle formation and retrograde transport between the Golgi and the endoplasmic reticulum (PubMed:19015319). Hydrolysis of ARF1-bound GTP leads to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity). Promotes the proper assembly of the COPI coat lattice, rather than just acting as a simple curvature-dependent GAP like ARFGAP1 (By similarity). Also acts as a regulator of STING1 activity, both by promoting cytokine secretion in certain cell types and promoting the proton channel activity of STING1 in the trans-Golgi (By similarity). {ECO:0000250|UniProtKB:Q8N6H7, ECO:0000269|PubMed:19015319}.
uniprot
proteins
mass_dalton
56556
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19015319
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
520
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:19015319}; Peripheral membrane protein {ECO:0000269|PubMed:19015319}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8N6H7}. Cytoplasm {ECO:0000250|UniProtKB:Q8N6H7}. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment. {ECO:0000250|UniProtKB:Q8N6H7}.
uniprot
proteins