Drc9
entrez
69707
canonical
uniprot
Q80W32
canonical
ensembl
ENSMUSG00000035578
resolver
ensp
ENSMUSP00000110752
resolver
enst
ENSMUST00000115100
resolver
genesymbol
Drc9
resolver
genesymbol_syn
Iqcg
resolver
uniprot_entry
DRC9_MOUSE
resolver
amino_acid_sequence
MDEEEVEVVESPSEVLQPEVTVVVTGEPPEAAEEDLDYEEEEETSPEVIETLSLLDVLRVSAVMEDVIDQLSILGYIIPVQYERRQSLTQKASHEGASMITTTPKKSTSLLTKEKSMMAENKQRGQDFTFKKPTKQTMMTLETLKKIQNDRQYFSDVIANAMMEMQDSGSFTSLLKALGKERDSKMNFHDVITREEKGRKQIKTLQKQLLDVKRERQMQVQNGNEYIAHLRDQLQEMKAKTNLENLYMKRNAELQISQTQKKCNRAEELLLEEIEKLRMKTEEENRVHTEIEMFLKKQQQKLEEKLEFWMEKFDKDTEAKQNELNALKAAKASDLVHLQDLAKMIREYEQVIIEDRIEKEKTRKKLEQDDLELRSIVKLQAWWRGSVVRKEIGNFKMPKKDKDDSKDSKGKEKEKRRKK
uniprot
proteins
function
FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (By similarity). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility (PubMed:24362311, PubMed:24849454). {ECO:0000250|UniProtKB:A3KQH2, ECO:0000250|UniProtKB:A8HQ54, ECO:0000269|PubMed:24362311, ECO:0000269|PubMed:24849454}.
uniprot
proteins
mass_dalton
49168
uniprot
proteins
protein_family
DRC9 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24362311
uniprot
proteins
pubmed
24787902
uniprot
proteins
pubmed
24849454
uniprot
proteins
pubmed
35547804
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24849454}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:24849454}. Cell projection, cilium {ECO:0000269|PubMed:24849454}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24849454}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8HQ54}. Note=First detected in the cytoplasm of pachytene spermatocytes. Colocalizes with alpha-tubulin at the manchette in developing spermatids. Detected in the flagellum of mature testicular spermatozoa, and in the flagellum and post-acrosomal region of the head of epididymal spermatozoa. Detected in cilia in trachea and oviduct. {ECO:0000269|PubMed:24849454}.
uniprot
proteins