Fgd1
entrez
14163
canonical
uniprot
P52734
canonical
ensembl
ENSMUSG00000025265
resolver
ensp
ENSMUSP00000026296
resolver
ensp
ENSMUSP00000108305
resolver
enst
ENSMUST00000026296
resolver
enst
ENSMUST00000112685
resolver
genesymbol
Fgd1
resolver
uniprot
A2ALP5
resolver
uniprot
Q3UG32
resolver
uniprot
Q921L2
resolver
uniprot_entry
A2ALP5_MOUSE
resolver
uniprot_entry
FGD1_MOUSE
resolver
uniprot_entry
Q3UG32_MOUSE
resolver
uniprot_sec
Q921L2
resolver
amino_acid_sequence
MHGHRVPGGPGPSDPERSAANTPGAAPLACADSDPGALEPGLPVSRGSGTALGGPLDPQFVGPSDASLGAPPSSRVLPCGPSPQHHRALRFSYHLEGSQPRPGLHQGNRILVKSLSLDPGQSLEPHPEGPQRLRSDPGPPTEIPGPRPSPLKRAPGPKPQVPPKPSYLQMPRVLPPPEPIPPPPSRPLPADPRVAKGLVPRAEASTSSAAVSSLIEKFEREPVIVASDRPAPGPCPVPPEPAMLPQPPPQPTGSQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDGPPIHSLCPGPPALASMPVALADPHRPGSQEVDSDLEEEEEEEEEEKEREIPVPPMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNMPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNRDDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLIYDNNRSNRVCTDCYVALHGAPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQRRWMAVLGRAGRGDTFCPGPTLSEDKEMEETPVAASGATAEPPEASQTRDKT
uniprot
proteins
function
FUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:12913069}.
uniprot
proteins
mass_dalton
106365
uniprot
proteins
mutagenesis
MUTAGEN 159; /note="P->A: Abolishes binding to DBNL."; /evidence="ECO:0000269|PubMed:12913069"; MUTAGEN 162; /note="P->A: Abolishes binding to DBNL."; /evidence="ECO:0000269|PubMed:12913069"; MUTAGEN 164; /note="K->E: No effect on binding to DBNL."; /evidence="ECO:0000269|PubMed:12913069
uniprot
proteins
pubmed
12913069
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17000758
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8535076
uniprot
proteins
sequence_length
960
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12913069}. Cell projection, lamellipodium {ECO:0000269|PubMed:12913069}. Cell projection, ruffle {ECO:0000269|PubMed:12913069}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12913069}. Note=Associated with membrane ruffles and lamellipodia.
uniprot
proteins