Kcnj15
entrez
170847
canonical
uniprot
Q91ZF1
canonical
ensembl
ENSRNOG00000062944
resolver
ensp
ENSRNOP00000091174
resolver
genesymbol
Kcnj15
resolver
uniprot_entry
KCJ15_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is regulated by variations of cytosolic pH; reversibly inhibited by acidic pH values. Inhibited by Ba(2+) and Cs(+) in a voltage-dependent manner. {ECO:0000250|UniProtKB:O88932}.
uniprot
proteins
amino_acid_sequence
MVARWVKGSEDAPLALQKIPDLQSGPRSLRMEAIHIGMSSAPLVKHSNGVGLKAHRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVVYYAIAFIHGDLELGESNSNHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVISKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQKLEEQYRQEDQRERELRSLLLQQSNV
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages (PubMed:11804844). The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity). {ECO:0000250, ECO:0000269|PubMed:11804844}.
uniprot
proteins
mass_dalton
45908
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ15 subfamily
uniprot
proteins
pubmed
11804844
uniprot
proteins
sequence_length
405
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:11804844}.
uniprot
proteins
transmembrane_region
TRANSMEM 91..117; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:P49655"; TRANSMEM 170..195; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:P49655
uniprot
proteins