SLC4A7
entrez
9497
canonical
uniprot
Q9Y6M7
canonical
ensembl
ENSG00000033867
resolver
ensp
ENSP00000295736
resolver
ensp
ENSP00000390394
resolver
ensp
ENSP00000394252
resolver
ensp
ENSP00000406605
resolver
ensp
ENSP00000406804
resolver
ensp
ENSP00000407382
resolver
ensp
ENSP00000411031
resolver
ensp
ENSP00000414797
resolver
ensp
ENSP00000416368
resolver
ensp
ENSP00000533106
resolver
ensp
ENSP00000605605
resolver
ensp
ENSP00000605608
resolver
ensp
ENSP00000633994
resolver
ensp
ENSP00000653112
resolver
enst
ENST00000445684
resolver
genesymbol
SLC4A7
resolver
genesymbol_syn
BT
resolver
genesymbol_syn
NBC2
resolver
genesymbol_syn
NBC2B
resolver
genesymbol_syn
NBC3
resolver
genesymbol_syn
NBCn1
resolver
genesymbol_syn
SBC2
resolver
genesymbol_syn
SLC4A6
resolver
hgnc
HGNC:11033
resolver
uniprot
A6NIA8
resolver
uniprot
B2CI53
resolver
uniprot
B5M449
resolver
uniprot
B5M450
resolver
uniprot
B5M451
resolver
uniprot
B5M452
resolver
uniprot
B5M453
resolver
uniprot
B6DY52
resolver
uniprot
B6DY53
resolver
uniprot
C9JST9
resolver
uniprot
D3K174
resolver
uniprot
D3K175
resolver
uniprot
E9PFN4
resolver
uniprot
O60350
resolver
uniprot
Q6AHZ9
resolver
uniprot
Q9HC88
resolver
uniprot
Q9UIB9
resolver
uniprot_entry
B5M450_HUMAN
resolver
uniprot_entry
E9PFN4_HUMAN
resolver
uniprot_entry
S4A7_HUMAN
resolver
uniprot_sec
A6NIA8
resolver
uniprot_sec
B2CI53
resolver
uniprot_sec
B5M449
resolver
uniprot_sec
B5M451
resolver
uniprot_sec
B5M452
resolver
uniprot_sec
B5M453
resolver
uniprot_sec
B6DY52
resolver
uniprot_sec
B6DY53
resolver
uniprot_sec
C9JST9
resolver
uniprot_sec
D3K174
resolver
uniprot_sec
D3K175
resolver
uniprot_sec
O60350
resolver
uniprot_sec
Q6AHZ9
resolver
uniprot_sec
Q9HC88
resolver
uniprot_sec
Q9UIB9
resolver
activity_regulation
ACTIVITY REGULATION: Transporter activity is regulated by CA2/carbonic anhydrase 2, cAMP and PKA. Insensitive to stilbene derivatives. Inhibited by 5-(N-ethyl-N-isopropyl)-amiloride (EIPA). {ECO:0000269|PubMed:10347222, ECO:0000269|PubMed:14736710}.
uniprot
proteins
amino_acid_sequence
MERFRLEKKLPGPDEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHVPFSKESRRRHRHRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCTTPVPTPQNSPPSSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALKGEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPVFHNGSTPTLGETPKEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLAQWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGWIISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPESKKKKEDDKKKKEKEEAERMLQDDDDTVHLPFEGGSLLQIPVKALKYSPDKPVSVKISFEDEPRKKYVDAETSL
uniprot
proteins
function
FUNCTION: Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry (PubMed:10347222, PubMed:12403779, PubMed:14578046, PubMed:14736710). Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (By similarity). Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis (PubMed:29779931). Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells (PubMed:35772404). {ECO:0000250|UniProtKB:Q8BTY2, ECO:0000269|PubMed:10347222, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:14578046, ECO:0000269|PubMed:14736710, ECO:0000269|PubMed:29779931, ECO:0000269|PubMed:35772404}.; FUNCTION: [Isoform 6]: Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis. {ECO:0000269|PubMed:29779931}.
uniprot
proteins
mass_dalton
136044
uniprot
proteins
mutagenesis
MUTAGEN 1127..1214; /note="Missing: Loss of cell membrane localization. Significant reduction in transport activity."; /evidence="ECO:0000269|PubMed:14578046"; MUTAGEN 1135..1136; /note="DD->NN: Loss of interaction with CA2. Loss of regulation by CA2."; /evidence="ECO:0000269|PubMed:14736710"; MUTAGEN 1163..1165; /note="DDD->NNN: No effect on interaction with CA2. No effect on regulation by CA2."; /evidence="ECO:0000269|PubMed:14736710"; MUTAGEN 1214; /note="L->G: Loss of interaction with ATP6V1B1."; /evidence="ECO:0000269|PubMed:12444018"; MUTAGEN Q9Y6M7-6:549; /note="T->I: No effect on cell membrane localization. Unable to rescue phagocyte deficient acidification phenotype of SLC4A7 knockout."; /evidence="ECO:0000269|PubMed:29779931"; MUTAGEN Q9Y6M7-6:811; /note="D->A: No effect on cell membrane localization. Unable to rescue phagocyte deficient acidification phenotype of SLC4A7 knockout."; /evidence="ECO:0000269|PubMed:29779931"; MUTAGEN Q9Y6M7-6:1008..1131; /note="Missing: Loss of cell membrane localization. Unable to rescue phagocyte deficient acidification phenotype of SLC4A7 knockout."; /evidence="ECO:0000269|PubMed:29779931
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
10347222
uniprot
proteins
pubmed
12403779
uniprot
proteins
pubmed
12444018
uniprot
proteins
pubmed
14578046
uniprot
proteins
pubmed
14736710
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
16301216
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19448079
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29779931
uniprot
proteins
pubmed
35772404
uniprot
proteins
pubmed
9610397
uniprot
proteins
sequence_length
1214
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:Q9R1N3}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q9R1N3}; Multi-pass membrane protein {ECO:0000255}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q9R1N3}. Cell membrane {ECO:0000269|PubMed:14578046, ECO:0000269|PubMed:29779931}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity). {ECO:0000250|UniProtKB:Q9R1N3}.; SUBCELLULAR LOCATION: [Isoform 6]: Cell membrane {ECO:0000269|PubMed:29779931}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 609..629; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 638..658; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 696..716; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 726..746; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 818..838; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 862..882; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 909..929; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 955..975; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1012..1032; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1035..1055; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1093..1113; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins