Bloc1s2
entrez
293938
canonical
uniprot
Q32WR5
canonical
ensembl
ENSRNOG00000012684
resolver
ensp
ENSRNOP00000068679
resolver
genesymbol
Bloc1s2
resolver
genesymbol_syn
Rsep1
resolver
genesymbol_syn
Sep1
resolver
uniprot_entry
BL1S2_RAT
resolver
amino_acid_sequence
MAAAAEGVPATRREEPPRDDAAVETAEEAKEPAEADINELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR
uniprot
proteins
function
FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation. {ECO:0000250|UniProtKB:Q6QNY1, ECO:0000250|UniProtKB:Q9CWG9}.
uniprot
proteins
mass_dalton
16067
uniprot
proteins
protein_family
BLOC1S2 family
uniprot
proteins
pubmed
16176350
uniprot
proteins
sequence_length
142
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q6QNY1}. Lysosome membrane {ECO:0000250|UniProtKB:Q6QNY1}. Note=Localizes to the centrosomes in a microtubule-dependent manner. {ECO:0000250|UniProtKB:Q6QNY1}.
uniprot
proteins