Klf3
entrez
16599
canonical
uniprot
Q60980
canonical
ensembl
ENSMUSG00000029178
resolver
ensp
ENSMUSP00000129363
resolver
ensp
ENSMUSP00000261309
resolver
enst
ENSMUST00000165536
resolver
genesymbol
Klf3
resolver
genesymbol_syn
Bklf
resolver
uniprot
Q545J5
resolver
uniprot_entry
KLF3_MOUSE
resolver
uniprot_entry
Q545J5_MOUSE
resolver
amino_acid_sequence
MLMFDPVPVKQEAMDPVSVSFPSNYIESMKPNKYGVIYSTPLPDKFFQTPEGLTHGIQVEPVDLTVNKRGSPPAAGGSPSSLKFPSHRRASPGLSMPSSSPPIKKYSPPSPGVQPFGVPLSMPPVMAAALSRHGIRSPGILPVIQPVVVQPVPFMYTSHLQQPLMVSLSEEMDNSNSGMPVPVIESYEKPLLQKKIKIEPGIEPQRTDYYPEEMSPPLMNPVSPPQALLQENHPSVIVQPGKRPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRHMLV
uniprot
proteins
function
FUNCTION: Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis. {ECO:0000269|PubMed:15684403, ECO:0000269|PubMed:8657145}.
uniprot
proteins
mass_dalton
38561
uniprot
proteins
mutagenesis
MUTAGEN 10; /note="K->A: Reduced sumoylation levels. No effect on DNA-binding and slight reduction of transcriptional repression. Abolishes sumoylation. No effect on DNA-binding but great reduction in transcriptional repression; when associated with A-197."; /evidence="ECO:0000269|PubMed:15684403"; MUTAGEN 12; /note="E->A: Slight reduction of transcriptional repression. Great reduction of transcriptional repression; when associated with A-199."; /evidence="ECO:0000269|PubMed:15684403"; MUTAGEN 197; /note="K->A: Reduced sumoylation levels. No effect on DNA-binding and slight reduction of transcriptional repression. Abolishes sumoylation. No effect on DNA-binding but great reduction of transcriptional repression; when associated with A-10."; /evidence="ECO:0000269|PubMed:15684403"; MUTAGEN 199; /note="E->A: Slight reduction of transcriptional repression. Great reduction of transcriptional repression; when associated with A-199."; /evidence="ECO:0000269|PubMed:15684403"; MUTAGEN 341; /note="H->A,D,E,N,Q,R: Little change in DNA-binding ability."; /evidence="ECO:0000269|PubMed:12736264
uniprot
proteins
post_translational_modification
PTM: Sumoylated with SUMO1. Sumoylation is enhanced by PIAS1, PIAS2alpha and PIAS2beta, and PIAS4, but not by Pc2. Enhances transcriptional repression, but has no effect on DNA binding. Sumoylation on Lys-197 is the major site. {ECO:0000269|PubMed:15684403}.
uniprot
proteins
protein_family
Krueppel C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
12736264
uniprot
proteins
pubmed
15684403
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8657145
uniprot
proteins
sequence_length
344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins