SLC44A2
entrez
57153
canonical
uniprot
Q8IWA5
canonical
ensembl
ENSG00000129353
resolver
ensp
ENSP00000336888
resolver
ensp
ENSP00000385135
resolver
ensp
ENSP00000466664
resolver
genesymbol
SLC44A2
resolver
genesymbol_syn
CTL2
resolver
hgnc
HGNC:17292
resolver
uniprot
A0A088QCU6
resolver
uniprot
B2RBB1
resolver
uniprot
B3KNH3
resolver
uniprot
B4DFJ0
resolver
uniprot
F2Q9D7
resolver
uniprot
Q658V1
resolver
uniprot
Q658Z2
resolver
uniprot
Q6PJV7
resolver
uniprot
Q8N2F0
resolver
uniprot
Q9NY68
resolver
uniprot_entry
A0A088QCU6_HUMAN
resolver
uniprot_entry
CTL2_HUMAN
resolver
uniprot_sec
B2RBB1
resolver
uniprot_sec
B3KNH3
resolver
uniprot_sec
B4DFJ0
resolver
uniprot_sec
F2Q9D7
resolver
uniprot_sec
Q658V1
resolver
uniprot_sec
Q658Z2
resolver
uniprot_sec
Q6PJV7
resolver
uniprot_sec
Q8N2F0
resolver
uniprot_sec
Q9NY68
resolver
amino_acid_sequence
MGDERPHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQKGTKNENKPYLFYFNIVKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNARSSRDFEYYKQFCVPGFKNNKGVAEVLQDGDCPAVLIPSKPLARRCFPAIHAYKGVLMVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWYWIIIGLVIAMAMSLLFIILLRFLAGIMVWVMIIMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLLYPLVTFFLLCLCIAYWASTAVFLSTSNEAVYKIFDDSPCPFTAKTCNPETFPSSNESRQCPNARCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRKPDDLPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCLMTCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVYGMCVDTLFLCFLEDLERNDGSAERPYFMSSTLKKLLNKTNKKAAES
uniprot
proteins
function
FUNCTION: [Isoform 1]: Choline/H+ antiporter, mainly in mitochondria (PubMed:10677542, PubMed:20665236, PubMed:23651124, PubMed:33789160). Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway (PubMed:33789160). {ECO:0000269|PubMed:10677542, ECO:0000269|PubMed:20665236, ECO:0000269|PubMed:23651124, ECO:0000269|PubMed:33789160}.; FUNCTION: [Isoform 3]: Does not exhibit choline transporter activity. {ECO:0000269|PubMed:10677542, ECO:0000269|PubMed:20665236}.
uniprot
proteins
mass_dalton
80124
uniprot
proteins
protein_family
CTL (choline transporter-like) family
uniprot
proteins
pubmed
10677542
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14973250
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
17926100
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
20665236
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23651124
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
33789160
uniprot
proteins
sequence_length
706
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:33789160}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000305|PubMed:33789160}; Multi-pass membrane protein {ECO:0000255}. Note=Mainly expressed in mitochondria. {ECO:0000250|UniProtKB:B4F795}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 257..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 316..336; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 365..385; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 458..480; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 505..525; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 564..584; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 600..620; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 639..659; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins