Mrap
entrez
77037
canonical
uniprot
Q9D159
canonical
ensembl
ENSMUSG00000039956
resolver
ensp
ENSMUSP00000043890
resolver
genesymbol
Mrap
resolver
genesymbol_syn
Falp
resolver
uniprot
Q3TZ49
resolver
uniprot
Q8R439
resolver
uniprot_entry
MRAP_MOUSE
resolver
uniprot_sec
Q3TZ49
resolver
uniprot_sec
Q8R439
resolver
amino_acid_sequence
MANGTDASVPLTSYEYYLDYIDLIPVDEKKLKANKHSIVIALWLSLATFVVLLFLILLYMSWSGSPQMRHSPQPQPICSWTHSFNLPLCLRRASLQTTEEPGRRAGTDQWLTQQSPSASAPGPLALP
uniprot
proteins
function
FUNCTION: Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
14170
uniprot
proteins
protein_family
MRAP family
uniprot
proteins
pubmed
12054497
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
127
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins