NKX3-1
entrez
4824
canonical
uniprot
Q99801
canonical
ensembl
ENSG00000167034
resolver
ensp
ENSP00000370253
resolver
ensp
ENSP00000429729
resolver
genesymbol
NKX3-1
resolver
genesymbol_syn
NKX3.1
resolver
genesymbol_syn
NKX3A
resolver
hgnc
HGNC:7838
resolver
uniprot
O15465
resolver
uniprot
Q9H2P4
resolver
uniprot
Q9H2P5
resolver
uniprot
Q9H2P6
resolver
uniprot
Q9H2P7
resolver
uniprot
Q9HBG0
resolver
uniprot_entry
NKX31_HUMAN
resolver
uniprot_sec
O15465
resolver
uniprot_sec
Q9H2P4
resolver
uniprot_sec
Q9H2P5
resolver
uniprot_sec
Q9H2P6
resolver
uniprot_sec
Q9H2P7
resolver
uniprot_sec
Q9HBG0
resolver
amino_acid_sequence
MLRVPEPRPGEAKAEGAAPPTPSKPLTSFLIQDILRDGAQRQGGRTSSQRQRDPEPEPEPEPEGGRSRAGAQNDQLSTGPRAAPEEAETLAETEPERHLGSYLLDSENTSGALPRLPQTPKQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKNLKLTETQVKIWFQNRRYKTKRKQLSSELGDLEKHSSLPALKEEAFSRASLVSVYNSYPYYPYLYCVGSWSPAFW
uniprot
proteins
function
FUNCTION: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}.
uniprot
proteins
mass_dalton
26350
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues. {ECO:0000269|PubMed:18077445}.
uniprot
proteins
protein_family
NK-3 homeobox family
uniprot
proteins
pubmed
11137288
uniprot
proteins
pubmed
11809674
uniprot
proteins
pubmed
12972618
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18077445
uniprot
proteins
pubmed
19462257
uniprot
proteins
pubmed
9226374
uniprot
proteins
pubmed
9377551
uniprot
proteins
pubmed
9537602
uniprot
proteins
sequence_length
234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11137288}.
uniprot
proteins