IL18R1
entrez
8809
canonical
uniprot
Q13478
canonical
ensembl
ENSG00000115604
resolver
ensp
ENSP00000233957
resolver
ensp
ENSP00000386663
resolver
ensp
ENSP00000387211
resolver
ensp
ENSP00000536271
resolver
ensp
ENSP00000536272
resolver
ensp
ENSP00000536273
resolver
ensp
ENSP00000536274
resolver
ensp
ENSP00000536275
resolver
ensp
ENSP00000536277
resolver
ensp
ENSP00000776524
resolver
ensp
ENSP00000776525
resolver
enst
ENST00000233957
resolver
enst
ENST00000409599
resolver
enst
ENST00000410040
resolver
enst
ENST00000866213
resolver
genesymbol
IL18R1
resolver
genesymbol_syn
IL1RRP
resolver
hgnc
HGNC:5988
resolver
uniprot
B2R9Y5
resolver
uniprot
B7ZKV7
resolver
uniprot
Q52LC9
resolver
uniprot_entry
B7ZKV7_HUMAN
resolver
uniprot_entry
IL18R_HUMAN
resolver
uniprot_sec
B2R9Y5
resolver
uniprot_sec
Q52LC9
resolver
amino_acid_sequence
MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCFTERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSES
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:14528293, PubMed:25261253, PubMed:25500532, PubMed:37993714, PubMed:8626725). Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity). {ECO:0000250|UniProtKB:Q61098, ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:14528293, ECO:0000269|PubMed:25261253, ECO:0000269|PubMed:25500532, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:8626725}.
uniprot
proteins
mass_dalton
62304
uniprot
proteins
mutagenesis
MUTAGEN 297; /note="N->Q: Decreases the affinity for IL18 suggesting that the N-linked glycosylation contributes to ligand recognition."; /evidence="ECO:0000269|PubMed:25500532
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex. {ECO:0000269|PubMed:25261253, ECO:0000269|PubMed:25500532}.
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
10653850
uniprot
proteins
pubmed
10925275
uniprot
proteins
pubmed
11046021
uniprot
proteins
pubmed
14528293
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
25261253
uniprot
proteins
pubmed
25500532
uniprot
proteins
pubmed
37993714
uniprot
proteins
pubmed
8626725
uniprot
proteins
pubmed
9325300
uniprot
proteins
sequence_length
541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:14528293}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 330..350; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins