Ppm1b
entrez
19043
canonical
uniprot
P36993
canonical
ensembl
ENSMUSG00000061130
resolver
ensp
ENSMUSP00000079107
resolver
ensp
ENSMUSP00000107923
resolver
ensp
ENSMUSP00000107924
resolver
ensp
ENSMUSP00000157013
resolver
ensp
ENSMUSP00000157282
resolver
ensp
ENSMUSP00000181518
resolver
ensp
ENSMUSP00000181520
resolver
ensp
ENSMUSP00000181525
resolver
ensp
ENSMUSP00000181531
resolver
ensp
ENSMUSP00000181532
resolver
ensp
ENSMUSP00000181533
resolver
ensp
ENSMUSP00000181542
resolver
ensp
ENSMUSP00000357545
resolver
ensp
ENSMUSP00000357546
resolver
ensp
ENSMUSP00000357557
resolver
ensp
ENSMUSP00000357558
resolver
ensp
ENSMUSP00000357559
resolver
enst
ENSMUST00000080217
resolver
genesymbol
Ppm1b
resolver
genesymbol_syn
Pp2c2
resolver
genesymbol_syn
Pppm1b
resolver
genesymbol_syn
ppm1b1
resolver
genesymbol_syn
ppm1b2
resolver
uniprot
F7CQJ2
resolver
uniprot
Q546R1
resolver
uniprot
Q99NF7
resolver
uniprot_entry
F7CQJ2_MOUSE
resolver
uniprot_entry
PPM1B_MOUSE
resolver
uniprot_entry
Q546R1_MOUSE
resolver
uniprot_entry
Q99NF7_MOUSE
resolver
amino_acid_sequence
MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLDNWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAADKSGSALEPSVESVKTGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMVSPTHMYFINCGDSRAVLCRNGQVCFSTQDHKPCNPVEKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEIVRAEEDEFVVLACDGIWDVMSNEELCEFVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSVVLVCFSNAPKVSEEAVKRDSELDKHLESRVEEIMQKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRHVIEAVYSRLNPHKDNDGGAGDLEDSLVAL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Enzyme with a broad specificity. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:23088624}.
uniprot
proteins
mass_dalton
42795
uniprot
proteins
post_translational_modification
PTM: Isgylation negatively regulates its activity. {ECO:0000250}.; PTM: N-myristoylation is essential for the recognition of its substrates for dephosphorylation. {ECO:0000269|PubMed:23088624}.
uniprot
proteins
protein_family
PP2C family
uniprot
proteins
pubmed
10469137
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22781750
uniprot
proteins
pubmed
23088624
uniprot
proteins
pubmed
7733667
uniprot
proteins
pubmed
8038726
uniprot
proteins
pubmed
8274020
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22781750, ECO:0000269|PubMed:23088624}. Membrane {ECO:0000269|PubMed:23088624}; Lipid-anchor {ECO:0000269|PubMed:23088624}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000269|PubMed:23088624}.
uniprot
proteins