Spcs3
entrez
317409
canonical
uniprot
Q568Z4
canonical
ensembl
ENSRNOG00055025642
resolver
ensembl
ENSRNOG00055025655
resolver
ensembl
ENSRNOG00060023015
resolver
ensembl
ENSRNOG00060023051
resolver
ensembl
ENSRNOG00065006426
resolver
ensembl
ENSRNOG00065006427
resolver
ensp
ENSRNOP00055036188
resolver
ensp
ENSRNOP00055036192
resolver
ensp
ENSRNOP00060032916
resolver
ensp
ENSRNOP00060032963
resolver
ensp
ENSRNOP00065007186
resolver
ensp
ENSRNOP00065007193
resolver
enst
ENSRNOT00055044232
resolver
enst
ENSRNOT00055044236
resolver
enst
ENSRNOT00060039830
resolver
enst
ENSRNOT00060039891
resolver
enst
ENSRNOT00065009884
resolver
enst
ENSRNOT00065009890
resolver
genesymbol
Spcs3
resolver
uniprot_entry
SPCS3_RAT
resolver
amino_acid_sequence
MNTLLSRANSLFAFTLSVMAALTLGCILTTAFKDRSAPVRLHVSRILLKKVEDFTGPRKKSDLGFITFHISADLEKTFDWNVKQLFLYLSAEYSTKSNAVNQVVLWDKILLRGENPKLNLKDVKSKYFFFDDGHGLKGNRNVTLTLSWQVIPIAGILPLVTGSGRVSVPFPDSYEIATTF
uniprot
proteins
function
FUNCTION: Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity). {ECO:0000250|UniProtKB:P61009, ECO:0000250|UniProtKB:Q12133}.
uniprot
proteins
mass_dalton
20160
uniprot
proteins
protein_family
SPCS3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
180
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P61008}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P61008}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins