PCID2
entrez
55795
canonical
uniprot
Q5JVF3
canonical
ensembl
ENSG00000126226
resolver
ensp
ENSP00000246505
resolver
ensp
ENSP00000337405
resolver
ensp
ENSP00000364606
resolver
ensp
ENSP00000364608
resolver
ensp
ENSP00000364626
resolver
ensp
ENSP00000364628
resolver
ensp
ENSP00000622657
resolver
ensp
ENSP00000659539
resolver
ensp
ENSP00000702915
resolver
genesymbol
PCID2
resolver
hgnc
HGNC:25653
resolver
uniprot
A6NK09
resolver
uniprot
Q3ZCX1
resolver
uniprot
Q5TC57
resolver
uniprot
Q5TC58
resolver
uniprot
Q9H7K1
resolver
uniprot
Q9HBZ7
resolver
uniprot
Q9NUK6
resolver
uniprot
Q9NVY1
resolver
uniprot
Q9NW44
resolver
uniprot
Q9NWH3
resolver
uniprot_entry
PCID2_HUMAN
resolver
uniprot_sec
A6NK09
resolver
uniprot_sec
Q3ZCX1
resolver
uniprot_sec
Q5TC57
resolver
uniprot_sec
Q5TC58
resolver
uniprot_sec
Q9H7K1
resolver
uniprot_sec
Q9HBZ7
resolver
uniprot_sec
Q9NUK6
resolver
uniprot_sec
Q9NVY1
resolver
uniprot_sec
Q9NW44
resolver
uniprot_sec
Q9NWH3
resolver
amino_acid_sequence
MAHITINQYLQQVYEAIDSRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRVFANNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRVTYKYYVGRKAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTVELLKKYHLMQFAEVTRAVSEGNLLLLHEALAKHEAFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMQVEDVDIDEVQCILANLIYMGHVKGYISHQHQKLVVSKQNPFPPLSTVC
uniprot
proteins
function
FUNCTION: Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:22307388). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability (PubMed:24896180). Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (By similarity). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (By similarity). {ECO:0000250|UniProtKB:Q8BFV2, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:24896180, ECO:0000305|PubMed:23591820}.
uniprot
proteins
mass_dalton
46030
uniprot
proteins
protein_family
CSN12 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22307388
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23591820
uniprot
proteins
pubmed
24896180
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23591820}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:23591820}.
uniprot
proteins