ENTR1
entrez
10807
canonical
uniprot
Q96C92
canonical
ensembl
ENSG00000165689
resolver
ensp
ENSP00000298537
resolver
ensp
ENSP00000349929
resolver
ensp
ENSP00000360790
resolver
ensp
ENSP00000588267
resolver
genesymbol
ENTR1
resolver
genesymbol_syn
SDCCAG3
resolver
hgnc
HGNC:10667
resolver
uniprot
A6NCP1
resolver
uniprot
O60525
resolver
uniprot
Q5SXN1
resolver
uniprot
Q5SXN2
resolver
uniprot
Q5SXN3
resolver
uniprot
Q5SXN4
resolver
uniprot
Q5SXN8
resolver
uniprot
Q6V704
resolver
uniprot
Q9NVY5
resolver
uniprot_entry
ENTR1_HUMAN
resolver
uniprot_sec
A6NCP1
resolver
uniprot_sec
O60525
resolver
uniprot_sec
Q5SXN1
resolver
uniprot_sec
Q5SXN2
resolver
uniprot_sec
Q5SXN3
resolver
uniprot_sec
Q5SXN4
resolver
uniprot_sec
Q5SXN8
resolver
uniprot_sec
Q6V704
resolver
uniprot_sec
Q9NVY5
resolver
amino_acid_sequence
MSGYQRRPGATPLSRARSLAIPDAPAFYERRSCLPQLNCERPHGRDLDSPFFGIRPAFMCYVPSPVLASVGDTDFGYGKGKCSKQSPSGAHGTHFGDDRFEDLEEANPFSFREFLKTKNLGLSKEDPASRIYAKEASRHSLGLDHNSPPSQTGGYGLEYQQPFFEDPTGAGDLLDEEEDEDTGWSGAYLPSAIEQTHPERVPAGTSPCSTYLSFFSTPSELAGPESLPSWALSDTDSRVSPASPAGSPSADFAVHGESLGDRHLRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEMVRTLERKLEAKMIKEESDYHDLESVVQQVEQNLELMTKRAVKAENHVVKLKQEISLLQAQVSNFQRENEALRCGQGASLTVVKQNADVALQNLRVVMNSAQASIKQLVSGAETLNLVAEILKSIDRISEVKDEEEDS
uniprot
proteins
function
FUNCTION: Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis (PubMed:23108400, PubMed:25278552, PubMed:27767179). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400). Plays a role in the formation of cilia (PubMed:27767179). Involved in cargo protein localization, such as PKD2, at primary cilia (PubMed:27767179). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:A2AIW0, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25278552, ECO:0000269|PubMed:27767179}.
uniprot
proteins
mass_dalton
47961
uniprot
proteins
mutagenesis
MUTAGEN 190; /note="P->A: Disrupts interaction with PTPN13."; /evidence="ECO:0000269|PubMed:23108400"; MUTAGEN 194; /note="E->A: Disrupts interaction with PTPN13."; /evidence="ECO:0000269|PubMed:23108400
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:23108400}.
uniprot
proteins
protein_family
ENTR1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23108400
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25278552
uniprot
proteins
pubmed
27767179
uniprot
proteins
pubmed
27812135
uniprot
proteins
pubmed
9610721
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A2AIW0}. Early endosome {ECO:0000269|PubMed:23108400}. Endosome {ECO:0000269|PubMed:25278552}. Recycling endosome {ECO:0000269|PubMed:23108400}. Midbody {ECO:0000269|PubMed:23108400}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:27767179}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27767179}. Note=Colocalizes in a WASHC2-dependent manner with the retromer CSC complex at endosomes (PubMed:25278552). During cytokinesis colocalized with PTPN13 at the midbody (PubMed:23108400). Colocalizes with IFT88 and gamma-tubulin at the basal body of primary cilia (PubMed:27767179). Colocalizes with IFT88 and pericentrin at the centrosome (PubMed:27767179). {ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25278552, ECO:0000269|PubMed:27767179}.
uniprot
proteins