Gpm6a
entrez
234267
canonical
uniprot
P35802
canonical
ensembl
ENSMUSG00000031517
resolver
ensp
ENSMUSP00000033915
resolver
enst
ENSMUST00000033915
resolver
genesymbol
Gpm6a
resolver
genesymbol_syn
M6a
resolver
uniprot
Q542P2
resolver
uniprot
Q8R1P3
resolver
uniprot_entry
GPM6A_MOUSE
resolver
uniprot_entry
Q542P2_MOUSE
resolver
uniprot_entry
Q8R1P3_MOUSE
resolver
amino_acid_sequence
MEENMEEGQTQKGCFECCIKCLGGIPYASLIATILLYAGVALFCGCGHEALSGTVNILQTYFELARTAGDTLDVFTMIDIFKYVIYGIAAAFFVYGILLMVEGFFTTGAIKDLYGDFKITTCGRCVSAWFIMLTYLFMLAWLGVTAFTSLPVYMYFNVWTICRNTTLVEGANLCLDLRQFGIVTIGEEKKICTASENFLRMCESTELNMTFHLFIVALAGAGAAVIAMVHYLMVLSANWAYVKDACRMQKYEDIKSKEEQELHDIHSTRSKERLNAYT
uniprot
proteins
function
FUNCTION: Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. Conflictingly, PubMed:22162747 reports that induced cellular protrusions are simple membrane-wrapped tubules without actin or tubulin-based cytoskeletons and with Gpm6a gliding along membrane edges indicative for a function in actin-independent membrane deformation. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. {ECO:0000269|PubMed:18522499, ECO:0000269|PubMed:18776950, ECO:0000269|PubMed:22162747}.
uniprot
proteins
mass_dalton
31149
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P51674}.; PTM: Palmitoylated by ZDHHC17/HIP14. {ECO:0000250|UniProtKB:P51674}.
uniprot
proteins
protein_family
Myelin proteolipid protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18522499
uniprot
proteins
pubmed
18776950
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21714103
uniprot
proteins
pubmed
22162747
uniprot
proteins
pubmed
8398137
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21714103}; Multi-pass membrane protein {ECO:0000269|PubMed:21714103}. Cell projection, axon {ECO:0000269|PubMed:21714103}. Cell projection, growth cone {ECO:0000269|PubMed:21714103}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q812E9}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q812E9}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q812E9}. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons (By similarity). Localized to the growth cone edge membrane of elongating axons (PubMed:21714103). {ECO:0000250|UniProtKB:Q812E9, ECO:0000269|PubMed:21714103}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 85..105; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins