Jam3
entrez
315509
canonical
uniprot
Q68FQ2
canonical
ensembl
ENSRNOG00000009149
resolver
ensembl
ENSRNOG00055012390
resolver
ensembl
ENSRNOG00060026930
resolver
ensembl
ENSRNOG00065015326
resolver
ensp
ENSRNOP00000012247
resolver
ensp
ENSRNOP00055017093
resolver
ensp
ENSRNOP00060038986
resolver
ensp
ENSRNOP00065020016
resolver
enst
ENSRNOT00000012247
resolver
enst
ENSRNOT00055021148
resolver
enst
ENSRNOT00060046883
resolver
enst
ENSRNOT00065025504
resolver
genesymbol
Jam3
resolver
uniprot_entry
JAM3_RAT
resolver
amino_acid_sequence
MALSRRLRLRLCARLPDFFLLLLFRGCVIEAVNLKSSNRNPVVHEFESVELSCIITDSQTNDPRIEWKKIQDGQTTYVYFDNKIQGDLAGRTDVFGKTSLRIWNVTRSDSAIYRCEVVALNDRKEVDELTIELIVQVKPVAPVCRVPKAVPVGKAATLQCQESEGYPRPYYSWYRNDVPLPTDSRANPRFQNSSFHVNSETGTLVFSAVHKEDSGQYYCIASNDAGAARCEGQDMEVYDLNIAGIIGGVLVVLIVLAVITMGICCAYRRGCFISSKQDGESYKSPGKHEGVNYIRTSEEGDFRHKSSFVI
uniprot
proteins
function
FUNCTION: Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (By similarity). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). Plays a role in angiogenesis. Plays a role in the regulation of cell migration (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). {ECO:0000250|UniProtKB:A3KPA0, ECO:0000250|UniProtKB:Q9BX67, ECO:0000250|UniProtKB:Q9D8B7}.; FUNCTION: [Soluble form of JAM-C]: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis. {ECO:0000250|UniProtKB:Q9BX67}.
uniprot
proteins
mass_dalton
34783
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved from endothelial cells surface into a soluble form by ADAM10 and ADAM17; the release of soluble JAM3 is increased by pro-inflammatory factors. {ECO:0000250|UniProtKB:Q9BX67}.; PTM: S-palmitoylated by ZDHHC7. S-palmitoylation promotes expression at tight junctions. {ECO:0000250|UniProtKB:Q9BX67}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24090084
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BX67}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9BX67}. Cell junction {ECO:0000250|UniProtKB:Q9BX67}. Cell junction, desmosome {ECO:0000250|UniProtKB:Q9BX67}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9BX67}. Note=Detected in the acrosome region in developing spermatids (By similarity). In epithelial cells, it is expressed at desmosomes but not at tight junctions (By similarity). Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts (By similarity). {ECO:0000250|UniProtKB:Q9BX67, ECO:0000250|UniProtKB:Q9D8B7}.; SUBCELLULAR LOCATION: [Soluble form of JAM-C]: Secreted {ECO:0000250|UniProtKB:Q9BX67}.
uniprot
proteins
transmembrane_region
TRANSMEM 242..262; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins