TMEM203
entrez
94107
canonical
uniprot
Q969S6
canonical
ensembl
ENSG00000187713
resolver
ensp
ENSP00000375053
resolver
enst
ENST00000343666
resolver
genesymbol
TMEM203
resolver
hgnc
HGNC:28217
resolver
uniprot
Q6NW08
resolver
uniprot_entry
TM203_HUMAN
resolver
uniprot_sec
Q6NW08
resolver
amino_acid_sequence
MLFSLRELVQWLGFATFEIFVHLLALLVFSVLLALRVDGLVPGLSWWNVFVPFFAADGLSTYFTTIVSVRLFQDGEKRLAVLRLFWVLTVLSLKFVFEMLLCQKLAEQTRELWFGLITSPLFILLQLLMIRACRVN
uniprot
proteins
function
FUNCTION: Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873). Acts as a regulator of STING-mediated inflammatory signaling in macrophages (PubMed:31346090). Forms a complex with STING, promoting the activity of TBK1 kinase and the transcription factor IRF3, leading to activation of type I interferon expression (By similarity). {ECO:0000250|UniProtKB:Q8R235, ECO:0000269|PubMed:25996873, ECO:0000269|PubMed:31346090}.
uniprot
proteins
mass_dalton
15760
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25996873
uniprot
proteins
pubmed
31346090
uniprot
proteins
sequence_length
136
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25996873}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250|UniProtKB:Q8R235}. Lysosome membrane {ECO:0000250|UniProtKB:Q8R235}; Multi-pass membrane protein {ECO:0000255}. Note=Co-localizes with STING1 in the lysosome membrane, mediates lysosomal localization of STING1. {ECO:0000250|UniProtKB:Q8R235}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..34; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 50..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 81..101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins