Slamf7
entrez
75345
canonical
uniprot
Q8BHK6
canonical
ensembl
ENSMUSG00000038179
resolver
ensp
ENSMUSP00000106907
resolver
ensp
ENSMUSP00000141259
resolver
ensp
ENSMUSP00000141426
resolver
ensp
ENSMUSP00000141871
resolver
enst
ENSMUST00000111276
resolver
enst
ENSMUST00000192024
resolver
enst
ENSMUST00000192195
resolver
enst
ENSMUST00000194531
resolver
genesymbol
Slamf7
resolver
uniprot
A0A0A6YW73
resolver
uniprot
A0A0R4J2D6
resolver
uniprot
A0A0R4J2D8
resolver
uniprot
Q8BTL2
resolver
uniprot
Q8CJ63
resolver
uniprot
Q8CJ64
resolver
uniprot
Q8CJ65
resolver
uniprot
Q91XA0
resolver
uniprot_entry
A0A0A6YW73_MOUSE
resolver
uniprot_entry
A0A0R4J2D6_MOUSE
resolver
uniprot_entry
A0A0R4J2D8_MOUSE
resolver
uniprot_entry
SLAF7_MOUSE
resolver
uniprot_sec
Q8BTL2
resolver
uniprot_sec
Q8CJ63
resolver
uniprot_sec
Q8CJ64
resolver
uniprot_sec
Q8CJ65
resolver
uniprot_sec
Q91XA0
resolver
amino_acid_sequence
MARFSTYIIFTSVLCQLTVTAASGTLKKVAGALDGSVTFTLNITEIKVDYVVWTFNTFFLAMVKKDGVTSQSSNKERIVFPDGLYSMKLSQLKKNDSGAYRAEIYSTSSQASLIQEYVLHVYKHLSRPKVTIDRQSNKNGTCVINLTCSTDQDGENVTYSWKAVGQGDNQFHDGATLSIAWRSGEKDQALTCMARNPVSNSFSTPVFPQKLCEDAATDLTSLRGILYILCFSAVLILFAVLLTIFHTTWIKKGKGCEEDKKRVDRHQEMPDLCPHLEENADYDTIPYTEKRRPEEDAPNTFYSTVQIPKVVKSPSSLPAKPLVPRSLSFENVI
uniprot
proteins
function
FUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:19648922). Mediates natural killer (NK) cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (By similarity). Positively regulates NK cell functions by a mechanism dependent on the adapter SH2D1B. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Also acts inhibitory in T-cells (PubMed:19151721). May play a role in lymphocyte adhesion (By similarity). In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (By similarity). {ECO:0000250|UniProtKB:Q9NQ25, ECO:0000269|PubMed:19151721, ECO:0000269|PubMed:19648922}.
uniprot
proteins
mass_dalton
37187
uniprot
proteins
mutagenesis
MUTAGEN 282; /note="Y->F: No effect on interaction with SH2D1B, increases NK cell activation in presence of SH2D1B, abolishes NK cell inhibition in absence of SH2D1B."; /evidence="ECO:0000269|PubMed:19151721"; MUTAGEN 287; /note="Y->F: No effect on interaction with SH2D1, no effect on NK cell activation in presence of SH2D1B, no effect on NK cell inhibition in absence of SH2D1B."; /evidence="ECO:0000269|PubMed:19151721"; MUTAGEN 302; /note="Y->F: Disrupts interaction with SH2D1B, abolishes NK cell activation in presence of SH2D1B, no effect on NK cell inhibition in absence of SH2D1B."; /evidence="ECO:0000269|PubMed:19151721
uniprot
proteins
pubmed
12242590
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19151721
uniprot
proteins
pubmed
19648922
uniprot
proteins
pubmed
24098802
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins