Fbxo16
entrez
50759
canonical
uniprot
Q9QZM9
canonical
ensembl
ENSMUSG00000034532
resolver
ensp
ENSMUSP00000153015
resolver
ensp
ENSMUSP00000153094
resolver
enst
ENSMUST00000224629
resolver
enst
ENSMUST00000226005
resolver
genesymbol
Fbxo16
resolver
genesymbol_syn
Fbx16
resolver
uniprot
A0A286YCP7
resolver
uniprot
Q0VGS0
resolver
uniprot
Q14BG9
resolver
uniprot
Q3TP74
resolver
uniprot
Q8C5V6
resolver
uniprot_entry
A0A286YCP7_MOUSE
resolver
uniprot_entry
FBX16_MOUSE
resolver
uniprot_entry
Q0VGS0_MOUSE
resolver
uniprot_entry
Q14BG9_MOUSE
resolver
uniprot_sec
Q3TP74
resolver
uniprot_sec
Q8C5V6
resolver
amino_acid_sequence
MMAFAPPKSIDGPKMQTKMSTWTPLNHQLLNDQVFEERRALLGKWFDKWTDSQRRRILTGLLERCSLSQQKFCCRKLQEKIPAEALDFTTKLPRVLSVYIFSFLDPRSLCRCAQVSWYWKSLAELDQLWMLKCLRFNWYISFSPTPFEQGVWKKHYIQMVRELHVTKPKTPPKDEFTTADVQPIPGNSPDEKQSPSLAFRSSSSLRKKNNPGEKELPPWRSSDKHPTDIIRFNYLDNCDPELFRLGRRKRSEVTPDFKRQLRDKKNKLQDRARLRKAQSLISLSSPPKVPVRLAWPLHLPVAPSDREAATEALLEHLQKHPGLQSPSPRLQSQS
uniprot
proteins
function
FUNCTION: Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Functions as a putative tumor suppressor by targeting nuclear beta-catenin/CTNNB1 for degradation independently of upstream activating signals, thereby inhibiting epithelial-to-mesenchymal transition. Controls the ubiquitination and degradation of hnRNPL. Negatively regulates NF-kappa-B signaling by mediating the polyubiquitination and degradation of RELA. Inhibits autophagy by promoting 'Lys-48'-linked polyubiquitination of the serine/threonine-protein kinase ULK1. {ECO:0000250|UniProtKB:Q8IX29}.
uniprot
proteins
mass_dalton
38987
uniprot
proteins
pubmed
10531037
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
334
uniprot
proteins