Slc12a7
entrez
308069
canonical
uniprot
Q5RK27
canonical
ensembl
ENSRNOG00000016372
resolver
ensp
ENSRNOP00000074714
resolver
ensp
ENSRNOP00000088698
resolver
enst
ENSRNOT00000078039
resolver
enst
ENSRNOT00000112535
resolver
genesymbol
Slc12a7
resolver
genesymbol_syn
Kcc4
resolver
uniprot
A0A0G2K8S1
resolver
uniprot
Q6T7Y5
resolver
uniprot
Q6TUA1
resolver
uniprot
Q6TUA2
resolver
uniprot_entry
A0A0G2K8S1_RAT
resolver
uniprot_entry
S12A7_RAT
resolver
uniprot_sec
Q6T7Y5
resolver
uniprot_sec
Q6TUA1
resolver
uniprot_sec
Q6TUA2
resolver
activity_regulation
ACTIVITY REGULATION: Activated by N-ethylmaleimide (NEM). Inhibited by furosemide, DIDS and bumetanide. The inhibition is much stronger in the presence of 50 mM K(+) in the uptake medium. Inhibited by DIOA. Inhibited by WNK3. {ECO:0000250|UniProtKB:Q9Y666}.
uniprot
proteins
amino_acid_sequence
MPTNFTVVPVEARADGAGDEAAERTEEPGSPESADPACPTPGDGNPRENSPFINNVEVERESYFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEDSRRREIKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPSAAIFQAETADGEAAALLNNMRVYGSCALALMAVVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFAPPDIPVCLLGNRTLANRNFDTCAKMQVVSNGTVTTALWRLFCNGSSLGASCDEYFVQNNVTEIQGIPGVASGVFLDNLWSTYSDKGAFVEKKGVSSVPVSEESRPGGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIIPFLQVFGHGKANGEPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALFAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDSEQCVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHVEAQRAEENIRSLMSAEKMKGFCQLVVSSNLRDGASHLIQSAGLGGMKHNTVLMAWPEAWKQADNPFSWKNFVDTVRDTTAAHQALLVAKNIDLFPQNQERFSDGNIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYEKTLMMEQRSQMLKQMQLSKNEREREAQLIHDRNTASHTVATARTEAPPTPDKVQMTWTKEKLIAEKHRNKDTGTSGFKDLFSLKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKSRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS
uniprot
proteins
function
FUNCTION: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (By similarity). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9Y666}.
uniprot
proteins
mass_dalton
119378
uniprot
proteins
protein_family
K/Cl co-transporter subfamily
uniprot
proteins
protein_family
SLC12A transporter family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16872584
uniprot
proteins
sequence_length
1083
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7YRU6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7YRU6}.
uniprot
proteins
transmembrane_region
TRANSMEM 120..142; /note="Discontinuously helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 150..172; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 197..225; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 250..271; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 272..300; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 420..440; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 451..473; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 505..531; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 555..573; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 574..598; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 613..635; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q9Y666"; TRANSMEM 636..651; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q9Y666
uniprot
proteins