PFKP
entrez
5214
canonical
uniprot
Q01813
canonical
ensembl
ENSG00000067057
resolver
ensp
ENSP00000370465
resolver
ensp
ENSP00000370517
resolver
ensp
ENSP00000408858
resolver
ensp
ENSP00000503786
resolver
ensp
ENSP00000514216
resolver
ensp
ENSP00000537441
resolver
enst
ENST00000381075
resolver
enst
ENST00000415005
resolver
enst
ENST00000676796
resolver
enst
ENST00000699222
resolver
genesymbol
PFKP
resolver
genesymbol_syn
PFKF
resolver
hgnc
HGNC:8878
resolver
uniprot
A0A7I2V3Z0
resolver
uniprot
A0A8V8TMY4
resolver
uniprot
B1APP6
resolver
uniprot
B3KS15
resolver
uniprot
Q5VSR7
resolver
uniprot
Q5VSR8
resolver
uniprot_entry
A0A7I2V3Z0_HUMAN
resolver
uniprot_entry
A0A8V8TMY4_HUMAN
resolver
uniprot_entry
B1APP6_HUMAN
resolver
uniprot_entry
PFKAP_HUMAN
resolver
uniprot_sec
B3KS15
resolver
uniprot_sec
Q5VSR7
resolver
uniprot_sec
Q5VSR8
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate. {ECO:0000255|HAMAP-Rule:MF_03184}.
uniprot
proteins
amino_acid_sequence
MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQPWSV
uniprot
proteins
ec_number
2.7.1.11
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
uniprot
proteins
mass_dalton
85596
uniprot
proteins
mutagenesis
MUTAGEN 386; /note="S->A: Decreased interaction with ATG4B."; /evidence="ECO:0000269|PubMed:33607258
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. {ECO:0000255|HAMAP-Rule:MF_03184}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-386 promotes interaction with ATG4B. {ECO:0000269|PubMed:33607258}.; PTM: GlcNAcylation decreases enzyme activity. {ECO:0000250}.
uniprot
proteins
protein_family
ATP-dependent PFK group I subfamily
uniprot
proteins
protein_family
Eukaryotic two domain clade 'E' sub-subfamily
uniprot
proteins
protein_family
Phosphofructokinase type A (PFKA) family
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
1834056
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
33607258
uniprot
proteins
pubmed
8117307
uniprot
proteins
sequence_length
784
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}.
uniprot
proteins