Fbxl7
entrez
448987
canonical
uniprot
Q5BJ29
canonical
ensembl
ENSMUSG00000043556
resolver
ensp
ENSMUSP00000061305
resolver
enst
ENSMUST00000059204
resolver
genesymbol
Fbxl7
resolver
genesymbol_syn
Kiaa0840
resolver
uniprot
Q6ZQ36
resolver
uniprot_entry
FBXL7_MOUSE
resolver
uniprot_sec
Q6ZQ36
resolver
amino_acid_sequence
MGANNGKQYGSEGKGSSSVSSDVSSSTDHTPTKAQRNVATSEDSDLSMRTLSTPSPALICPPTLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVIVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCTSIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRITDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLESLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQMLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:22306998, PubMed:25778398). During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (PubMed:22306998). It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 (PubMed:25778398). {ECO:0000269|PubMed:22306998, ECO:0000269|PubMed:25778398}.
uniprot
proteins
mass_dalton
54646
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:22306998, ECO:0000269|PubMed:25778398}.
uniprot
proteins
protein_family
FBXL7 family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22306998
uniprot
proteins
pubmed
25778398
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22306998}. Note=Localizes to the centrosome during spindle formation. {ECO:0000269|PubMed:22306998}.
uniprot
proteins