SH2B3
entrez
10019
canonical
uniprot
Q9UQQ2
canonical
ensembl
ENSG00000111252
resolver
ensp
ENSP00000345492
resolver
ensp
ENSP00000440597
resolver
ensp
ENSP00000566555
resolver
ensp
ENSP00000566556
resolver
ensp
ENSP00000605840
resolver
ensp
ENSP00000605842
resolver
enst
ENST00000341259
resolver
enst
ENST00000538307
resolver
enst
ENST00000896497
resolver
enst
ENST00000935781
resolver
enst
ENST00000935783
resolver
genesymbol
SH2B3
resolver
genesymbol_syn
LNK
resolver
hgnc
HGNC:29605
resolver
uniprot
B7Z7K6
resolver
uniprot
B9EGG5
resolver
uniprot
F5GYM4
resolver
uniprot
O95184
resolver
uniprot
Q59H48
resolver
uniprot
Q96BA5
resolver
uniprot_entry
B7Z7K6_HUMAN
resolver
uniprot_entry
F5GYM4_HUMAN
resolver
uniprot_entry
Q59H48_HUMAN
resolver
uniprot_entry
Q96BA5_HUMAN
resolver
uniprot_entry
SH2B3_HUMAN
resolver
uniprot_sec
B9EGG5
resolver
uniprot_sec
O95184
resolver
amino_acid_sequence
MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAKKFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
uniprot
proteins
disease_involvement
DISEASE: Celiac disease 13 (CELIAC13) [MIM:612011]: A multifactorial, chronic disorder of the small intestine caused by intolerance to gluten. It is characterized by immune-mediated enteropathy associated with failed intestinal absorption, and malnutrition. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes. {ECO:0000269|PubMed:18311140}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Type 1 diabetes mellitus (T1D) [MIM:222100]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269|PubMed:17554260}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}.
uniprot
proteins
mass_dalton
63225
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated by LCK.
uniprot
proteins
protein_family
SH2B adapter family
uniprot
proteins
pubmed
10799879
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17554260
uniprot
proteins
pubmed
18311140
uniprot
proteins
pubmed
20843259
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
575
uniprot
proteins