Rasgrf2
entrez
114513
canonical
uniprot
Q99JE4
canonical
ensembl
ENSRNOG00000056151
resolver
ensp
ENSRNOP00000069761
resolver
enst
ENSRNOT00000080165
resolver
genesymbol
Rasgrf2
resolver
genesymbol_syn
AABR07007642.1
resolver
genesymbol_syn
Grf2
resolver
uniprot
A0A0G2JW65
resolver
uniprot_entry
A0A0G2JW65_RAT
resolver
uniprot_entry
RGRF2_RAT
resolver
amino_acid_sequence
MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKAAEASRWHEKWFALYQNVLFYFEGEQSGRPAGMYLLEGCSCERTPAPPRTNAGPAGARDALDKQYYFTVLFGHEGQKPLELRCEEEQAGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKSEIVALNKTKERMRPYHTHQEEEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARLANWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEGNPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIQCTLIEEPDTSDDDTKGPGHMFGHLDFKIVVEPPDAAPFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLELFFATSQNNREHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSSLNSRIGALDLTTSSSSSSPTTTVHSPAASPPPHTAVPESAPADRAGDSTDMSPCRSPSTTPRHLRYRQPGGQVADSTHCAVSPASAFAIATAAAGHGSPPGFNNERTCDKEFIIRRTATNRVLNVLRHWVSKHSQDFELNNELKMNVLNLLEEVLRDPDLLPQERKATANILRALSQDDQDDIHLKLEDIIQMTDCPKAECFETLSAMELAEQITLLDHIVFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNEMSNLVASQIMNYADISSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWTKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTAYRIDQQPKVIQYLLDKALVIDEDTLYELSLKIEPRLPA
uniprot
proteins
function
FUNCTION: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}.
uniprot
proteins
mass_dalton
135827
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK5; down-regulates RASGRF2-mediated RAC1 activation. {ECO:0000269|PubMed:15128856}.; PTM: Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
10373510
uniprot
proteins
pubmed
11252168
uniprot
proteins
pubmed
15128856
uniprot
proteins
pubmed
9032266
uniprot
proteins
sequence_length
1190
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15128856}. Cell membrane {ECO:0000269|PubMed:15128856}; Peripheral membrane protein {ECO:0000269|PubMed:15128856}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15128856}; Peripheral membrane protein {ECO:0000269|PubMed:15128856}. Note=Translocates to membranes when activated (By similarity). Found both at cell periphery and along the axon of neurons. {ECO:0000250}.
uniprot
proteins