PAK3
entrez
5063
canonical
uniprot
O75914
canonical
ensembl
ENSG00000077264
resolver
ensp
ENSP00000262836
resolver
ensp
ENSP00000361077
resolver
ensp
ENSP00000361080
resolver
ensp
ENSP00000389172
resolver
ensp
ENSP00000401982
resolver
ensp
ENSP00000410853
resolver
ensp
ENSP00000428921
resolver
ensp
ENSP00000563639
resolver
ensp
ENSP00000563640
resolver
ensp
ENSP00000563643
resolver
ensp
ENSP00000563644
resolver
ensp
ENSP00000563647
resolver
ensp
ENSP00000616560
resolver
ensp
ENSP00000616561
resolver
genesymbol
PAK3
resolver
genesymbol_syn
OPHN3
resolver
hgnc
HGNC:8592
resolver
uniprot
A8K389
resolver
uniprot
B1GX77
resolver
uniprot
B1GX78
resolver
uniprot
B1GX79
resolver
uniprot
B2RCU6
resolver
uniprot
Q5JWX1
resolver
uniprot
Q5JWX2
resolver
uniprot
Q7Z2D6
resolver
uniprot
Q7Z2E4
resolver
uniprot
Q7Z3Z8
resolver
uniprot
Q8WWK5
resolver
uniprot
Q8WX23
resolver
uniprot
Q9P0J8
resolver
uniprot_entry
B2RCU6_HUMAN
resolver
uniprot_entry
PAK3_HUMAN
resolver
uniprot_sec
A8K389
resolver
uniprot_sec
B1GX77
resolver
uniprot_sec
B1GX78
resolver
uniprot_sec
B1GX79
resolver
uniprot_sec
Q5JWX1
resolver
uniprot_sec
Q5JWX2
resolver
uniprot_sec
Q7Z2D6
resolver
uniprot_sec
Q7Z2E4
resolver
uniprot_sec
Q7Z3Z8
resolver
uniprot_sec
Q8WWK5
resolver
uniprot_sec
Q8WX23
resolver
uniprot_sec
Q9P0J8
resolver
activity_regulation
ACTIVITY REGULATION: Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-436 and allows the kinase domain to adopt an active structure (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNSSR
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, X-linked 30 (XLID30) [MIM:300558]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked forms, while syndromic intellectual disability presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269|PubMed:10946356, ECO:0000269|PubMed:12884430, ECO:0000269|PubMed:9731525}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}.
uniprot
proteins
mass_dalton
62310
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated when activated by CDC42/p21.; PTM: Neddylated. {ECO:0000269|PubMed:20596523}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
10896954
uniprot
proteins
pubmed
10946356
uniprot
proteins
pubmed
11278486
uniprot
proteins
pubmed
11741931
uniprot
proteins
pubmed
12777533
uniprot
proteins
pubmed
12884430
uniprot
proteins
pubmed
12890786
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18507705
uniprot
proteins
pubmed
19036346
uniprot
proteins
pubmed
20596523
uniprot
proteins
pubmed
21177870
uniprot
proteins
pubmed
9731525
uniprot
proteins
sequence_length
559
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins