Pm20d1
entrez
212933
canonical
uniprot
Q8C165
canonical
ensembl
ENSMUSG00000042251
resolver
ensp
ENSMUSP00000046079
resolver
ensp
ENSMUSP00000108012
resolver
ensp
ENSMUSP00000282035
resolver
ensp
ENSMUSP00000282044
resolver
enst
ENSMUST00000048660
resolver
enst
ENSMUST00000112393
resolver
genesymbol
Pm20d1
resolver
uniprot
Q3UNX0
resolver
uniprot
Q8R117
resolver
uniprot_entry
P20D1_MOUSE
resolver
uniprot_sec
Q3UNX0
resolver
uniprot_sec
Q8R117
resolver
activity_regulation
ACTIVITY REGULATION: Lipoproteins are powerful coactivators of PM20D1 activity in vitro and NAA biosynthesis in vivo. {ECO:0000269|PubMed:32402239}.
uniprot
proteins
amino_acid_sequence
MAELLASLPAWAAVLLLFFATVSGSTGPRSRENRGASRIPSQFSEEERVAIKEALKGAIQIPTVSFSHEESNTTALAEFGEYIRKAFPTVFHSSLVQHEVVAKYSHLFTIQGSDPSLQPYMLMAHIDVVPAPEEGWEVPPFSGLERNGFIYGRGALDNKNSVMAILHALELLLIRNYSPKRSFFIALGHDEEVSGEKGAQKISALLQARGVQLAFLVDEGSFILEGFIPNLEKPVAMISVTEKGALDLMLQVNMTPGHSSAPPKETSIGILSAAVSRLEQTPMPNMFGGGPLKKTMKLLANEFSFPINIVLRNLWLFHPIVSRIMERNPITNALVRTTTALTMFNAGIKVNVIPPLAQATINCRIHPSQTVHEVLELVKNTVADDRVQLHVLRSFEPLPISPSDDQAMGYQLLQETIRSVFPEVDIVVPGICIANTDTRHYANITNGMYRFNPLPLNPQDFSGVHGINEKVSVQNYQNQVKFIFEFIQNADTYKEPVPHLHEL
uniprot
proteins
ec_number
3.5.1.114
uniprot
proteins
ec_number
3.5.1.14
uniprot
proteins
function
FUNCTION: Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction (Probable) (PubMed:27374330, PubMed:29533650, PubMed:29967167, PubMed:32271712, PubMed:32402239). Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure (PubMed:27374330, PubMed:29967167, PubMed:32271712). PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles (PubMed:32402239). {ECO:0000269|PubMed:27374330, ECO:0000269|PubMed:29533650, ECO:0000269|PubMed:29967167, ECO:0000269|PubMed:32271712, ECO:0000269|PubMed:32402239, ECO:0000305|PubMed:31659023}.
uniprot
proteins
mass_dalton
55663
uniprot
proteins
mutagenesis
MUTAGEN 125; /note="H->A: Loss of N-fatty-acyl-amino acid synthase/hydrolase activity."; /evidence="ECO:0000269|PubMed:27374330"; MUTAGEN 127; /note="D->A: Loss of N-fatty-acyl-amino acid synthase/hydrolase activity."; /evidence="ECO:0000269|PubMed:27374330"; MUTAGEN 465; /note="H->A: Loss of N-fatty-acyl-amino acid synthase/hydrolase activity."; /evidence="ECO:0000269|PubMed:27374330
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid metabolism. {ECO:0000269|PubMed:27374330, ECO:0000269|PubMed:29967167, ECO:0000269|PubMed:32271712, ECO:0000269|PubMed:32402239}.; PATHWAY: Energy metabolism; electron transfer. {ECO:0000269|PubMed:27374330, ECO:0000269|PubMed:29967167, ECO:0000269|PubMed:32271712}.; PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000269|PubMed:27374330, ECO:0000269|PubMed:29967167, ECO:0000269|PubMed:32271712, ECO:0000269|PubMed:32402239}.
uniprot
proteins
protein_family
Peptidase M20A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27374330
uniprot
proteins
pubmed
29533650
uniprot
proteins
pubmed
29967167
uniprot
proteins
pubmed
31659023
uniprot
proteins
pubmed
32271712
uniprot
proteins
pubmed
32402239
uniprot
proteins
sequence_length
503
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27374330, ECO:0000269|PubMed:32271712, ECO:0000269|PubMed:32402239}.
uniprot
proteins