SARAF
entrez
51669
canonical
uniprot
Q96BY9
canonical
ensembl
ENSG00000133872
resolver
ensp
ENSP00000256255
resolver
ensp
ENSP00000441351
resolver
genesymbol
SARAF
resolver
genesymbol_syn
TMEM66
resolver
genesymbol_syn
XTP3
resolver
hgnc
HGNC:28789
resolver
uniprot
A0A140VK59
resolver
uniprot
B3KQQ4
resolver
uniprot
B7Z9J1
resolver
uniprot
D3DSU7
resolver
uniprot
H9MHJ8
resolver
uniprot
H9MHJ9
resolver
uniprot
Q53HE8
resolver
uniprot
Q9UNZ3
resolver
uniprot
Q9Y683
resolver
uniprot_entry
A0A140VK59_HUMAN
resolver
uniprot_entry
SARAF_HUMAN
resolver
uniprot_sec
B3KQQ4
resolver
uniprot_sec
B7Z9J1
resolver
uniprot_sec
D3DSU7
resolver
uniprot_sec
H9MHJ8
resolver
uniprot_sec
H9MHJ9
resolver
uniprot_sec
Q53HE8
resolver
uniprot_sec
Q9UNZ3
resolver
uniprot_sec
Q9Y683
resolver
amino_acid_sequence
MAAACGPGAAGYCLLLGLHLFLLTAGPALGWNDPDRMLLRDVKALTLHYDRYTTSRRLDPIPQLKCVGGTAGCDSYTPKVIQCQNKGWDGYDVQWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLQKLKESGKQHGFASFSDYYYKWSSADSCNMSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTGPQNTGHGATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNRAYSPLHGGSGSYSVCSNSDTKTRTASGYGGTRRR
uniprot
proteins
function
FUNCTION: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. {ECO:0000269|PubMed:22464749}.
uniprot
proteins
mass_dalton
36975
uniprot
proteins
mutagenesis
MUTAGEN 148; /note="E->A: Dominant-negative mutant; leading to impair inhibition of SOCE."; /evidence="ECO:0000269|PubMed:22464749
uniprot
proteins
protein_family
SARAF family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
22464749
uniprot
proteins
pubmed
30481768
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22464749}; Single-pass type I membrane protein {ECO:0000269|PubMed:22464749}. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1-dependent manner following cytosolic Ca(2+) elevation.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 174..194; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins