Ggt1
entrez
14598
canonical
uniprot
Q60928
canonical
ensembl
ENSMUSG00000006345
resolver
ensp
ENSMUSP00000006508
resolver
ensp
ENSMUSP00000121312
resolver
ensp
ENSMUSP00000168942
resolver
ensp
ENSMUSP00000338524
resolver
ensp
ENSMUSP00000338529
resolver
ensp
ENSMUSP00000338532
resolver
enst
ENSMUST00000006508
resolver
enst
ENSMUST00000134503
resolver
genesymbol
Ggt1
resolver
genesymbol_syn
Ggt
resolver
genesymbol_syn
Ggtp
resolver
uniprot
Q4FK56
resolver
uniprot_entry
GGT1_MOUSE
resolver
uniprot_entry
Q4FK56_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by autocatalytic cleavage. {ECO:0000250|UniProtKB:P19440}.
uniprot
proteins
amino_acid_sequence
MKNRFLVLGLVAVVLVFVIIGLCIWLPYTSGKPDHVYSRAAVATDAKRCSEIGRDILQEGGSVVDAAIASLLCMGLMNAHSMGIGGGLFFTIYNSTTGKVEVINAREVAPRLANTTMFNNSKDSEEGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARHGFPVGKGLAIALDKKRDVIEKTPALCEVFCRQGKVLQEGETVTMPKLADTLQILAQEGAKAFYNGSLTAQIVKDIQEAGGIMTVEDLNNYRAELIEHPMSIGLGDATLYVPSAPLSGPVLILILNILKGYNFSPKSVATPEQKALTYHRIVEAFRFAYAKRTMLGDPKFVDVSQVIRNMSSEFYATQLRARITDETTHPAAYYEPEFYLQDDGGTAHLSAVSEDGSAVAATSTINLYFGSKVLSRVSGILFNDEMDDFSSPNFINQFRVAPSPANFIKPGKQPLSSMCPSIILDKDGQVRMVVGASGGTQITTSVALAIINSLWFGYDVKRAVEEPRLHNQLLPNTTTVEKDIDQVVTAGLKIRHHHTEVTPTFIAVVQAVVRASGGWAAASDSRKGGEPAGY
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Ggt1 are a cause of glutathionuria, severe growth failure, reduced life spans and infertility. Ggt1-deficient mice have multiple metabolic abnormalities and are dwarf. Some abnormalities can be ameliorated by N-acetylcysteine treatment. {ECO:0000269|PubMed:9139708}.
uniprot
proteins
ec_number
2.3.2.2
uniprot
proteins
ec_number
3.4.19.13
uniprot
proteins
ec_number
3.4.19.14
uniprot
proteins
function
FUNCTION: Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4 (By similarity). Indirectly regulates multiple aspects of skeletal biology (PubMed:12810527). {ECO:0000250|UniProtKB:P19440, ECO:0000269|PubMed:12810527}.
uniprot
proteins
mass_dalton
61563
uniprot
proteins
pathway_participation
PATHWAY: Sulfur metabolism; glutathione metabolism. {ECO:0000250|UniProtKB:P19440}.; PATHWAY: Lipid metabolism; leukotriene D4 biosynthesis. {ECO:0000250|UniProtKB:P19440}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated on both chains. {ECO:0000250|UniProtKB:P19440}.; PTM: Cleaved by autocatalysis into a large and a small subunit and the autocatalytic cleavage is essential to the functional activation of the enzyme. {ECO:0000250|UniProtKB:P19440}.
uniprot
proteins
protein_family
Gamma-glutamyltransferase family
uniprot
proteins
pubmed
10392451
uniprot
proteins
pubmed
12810527
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8566783
uniprot
proteins
pubmed
8755578
uniprot
proteins
pubmed
9139708
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P19440}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P07314}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..26; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000250|UniProtKB:P07314
uniprot
proteins