Tfb2m
entrez
289307
canonical
uniprot
Q5U2T7
canonical
ensembl
ENSRNOG00000002695
resolver
ensembl
ENSRNOG00055012066
resolver
ensembl
ENSRNOG00060006647
resolver
ensembl
ENSRNOG00065022298
resolver
ensp
ENSRNOP00000003618
resolver
ensp
ENSRNOP00000084899
resolver
ensp
ENSRNOP00055016506
resolver
ensp
ENSRNOP00060008105
resolver
ensp
ENSRNOP00065030749
resolver
enst
ENSRNOT00000003618
resolver
enst
ENSRNOT00000086734
resolver
enst
ENSRNOT00055020504
resolver
enst
ENSRNOT00060010893
resolver
enst
ENSRNOT00065037996
resolver
genesymbol
Tfb2m
resolver
uniprot
A0A8I5ZY51
resolver
uniprot_entry
A0A8I5ZY51_RAT
resolver
uniprot_entry
TFB2M_RAT
resolver
amino_acid_sequence
MRGLAMRLPPRLALSVLAGRGPSCILGSGAATRKDWQERNRRSFSDLYTQPLPDCDFEESSSWTHKSRSEPTRHIACKKSARNLVRDLLEHQNPSHQLILECNPGPGILTGALLKAGARVVAFESEKMFIPHLESLRKNADGELQVVHCDFFKIDPRYQELVRPDVNSHTIFQNLGIKAVPWSAGVPIKVFGILPNKHERRLLWKILFDLYSCESIYRYGRVELNMFISEKEFRKLIATPKRPDLYQVLGVLWQVACEIKFLHMEPWSSFSVHAENGHLEKSKHSESLNLLKQNLYLVRMTPRRTLFTENLSPLNYDMFFHLVKHCFGKRNAPIIHHLRSLSTVDPINILRQIRKRPGDTAAKMYPHDFKRLFETIERSEDSVFKWIYDYCSDDSEL
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Stimulates transcription independently of the methyltransferase activity. {ECO:0000250|UniProtKB:Q9H5Q4}.
uniprot
proteins
mass_dalton
46021
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
KsgA subfamily
uniprot
proteins
protein_family
rRNA adenine N(6)-methyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
uniprot
proteins