P2rx6
entrez
18440
canonical
uniprot
O54803
canonical
ensembl
ENSMUSG00000022758
resolver
ensp
ENSMUSP00000023441
resolver
ensp
ENSMUSP00000132727
resolver
enst
ENSMUST00000023441
resolver
enst
ENSMUST00000171002
resolver
genesymbol
P2rx6
resolver
genesymbol_syn
P2rxl1
resolver
uniprot
E9PY29
resolver
uniprot
G3X8W3
resolver
uniprot
Q149L9
resolver
uniprot
Q3UUD0
resolver
uniprot_entry
E9PY29_MOUSE
resolver
uniprot_entry
P2RX6_MOUSE
resolver
uniprot_entry
Q149L9_MOUSE
resolver
uniprot_sec
G3X8W3
resolver
uniprot_sec
Q3UUD0
resolver
amino_acid_sequence
MQLQPAGTGNMASAAAAALVSWGFLDYKTEKYVLTRNCRVGVSQRLLQLAVVVYVIGWALLAKKGYQERDLAPQTSVITKLKGVSVTQVKELENRLWDVADFVKPSQGENVFFLVTNFLVTPAQVQGRCPEHPSVPLANCWADEDCPEGETGTYSHGIKTGQCVVFNGTHRTCEIWSWCPVESGAVPRKPLLAQAKNFTLFIKNTVTFSKFNFSRSNALLTWDNTYFKHCLYDPLSSPYCPVFRIGDLVAMAGGDFEDLALLGGAVGISIHWDCNLDTKGSDCCPQYSFQLQQKGYNFRTANHWWAASGVETRSLLKLYGIRFDILVTGQAGKFALIPTAITVGTGAAWLGMVTFLCDLLLLYVDREAGFYWRTKYEEARAPKTTTNSS
uniprot
proteins
function
FUNCTION: Acts as a modulatory subunit rather than a functional channel. Unlike other P2XRs members, P2RX6 does not seem to form functional homotrimers (By similarity). P2RX6 requires the presence of P2RX4 or P2RX2 to form functional heterotrimeric receptors at the plasma membrane (By similarity). P2RX6 can be translocated to the nucleus, where it interacts with the splicing factor (SF3A1), to reduce the incidence of mRNA splicing. May function as a nuclear regulator of post-transcriptional modifications in neurons (PubMed:25874565). {ECO:0000250|UniProtKB:O15547, ECO:0000250|UniProtKB:P51579, ECO:0000269|PubMed:25874565}.
uniprot
proteins
mass_dalton
43099
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. N-linked glycosylation can affect trafficking to the membrane and function. {ECO:0000250|UniProtKB:P51579}.
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25874565
uniprot
proteins
pubmed
27254077
uniprot
proteins
pubmed
9852680
uniprot
proteins
sequence_length
389
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O15547}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P51579}. Nucleus {ECO:0000269|PubMed:25874565}. Nucleus inner membrane {ECO:0000269|PubMed:25874565}; Multi-pass membrane protein {ECO:0000255}. Note=Monomers remain anchored to the endoplasmic reticulum (ER) membrane by the hydrophobic N-terminal end. The retention of P2RX6 subunit in the ER allows it to reach the nucleus. Heteromerization of P2RX6 subunits with either P2RX2 or P2RX4 subunits guides the P2RX6 subunit to the plasma membrane. In neurons, mainly expressed in the cell body of the hippocampal neurons. {ECO:0000250|UniProtKB:P51579}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..66; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 336..356; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins