Adgrg5
entrez
382045
canonical
uniprot
Q3V3Z3
canonical
ensembl
ENSMUSG00000061577
resolver
ensp
ENSMUSP00000074155
resolver
ensp
ENSMUSP00000132628
resolver
ensp
ENSMUSP00000331613
resolver
genesymbol
Adgrg5
resolver
genesymbol_syn
Gm1109
resolver
genesymbol_syn
Gpr114
resolver
genesymbol_syn
Pgr27
resolver
uniprot
A6H6A1
resolver
uniprot
G5E8G8
resolver
uniprot_entry
AGRG5_MOUSE
resolver
uniprot_sec
A6H6A1
resolver
uniprot_sec
G5E8G8
resolver
activity_regulation
ACTIVITY REGULATION: Forms a heterodimer of 2 chains generated by proteolytic processing that remain associated through non-covalent interactions mediated by the GAIN-B domain (By similarity). In the inactivated receptor, the Stachel sequence (also named stalk) is embedded in the GAIN-B domain, where it adopts a beta-strand conformation (By similarity). On activation, the Stachel moves into the 7 transmembrane region and adopts a twisted hook-shaped configuration that forms contacts within the receptor, leading to coupling of a G-alpha protein, which activates signaling (By similarity). The cleaved GAIN-B and N-terminal domains can then dissociate from the rest of the receptor (By similarity). {ECO:0000250|UniProtKB:Q8IZF4}.
uniprot
proteins
amino_acid_sequence
MDPHGALFFYLCLLAAQVVLVETLSDLLVLMKRLEQPVGRGLSSRARHIHSLEQKLLNASFGGHNLTLQTNSIQSLVFKLSCDFPGLSLSSTTLTNVSQVRAPHAMQFPAELTKGACVTSRPAELRLICIYFFTAHLFQDDRNSSLLNNYVLGAQLDHRPVNNLQKPVNISFWHNRSLEGYTVSCVFWKEGASKSSWGAWSPEGCYTEQPSATQVLCHCNHLTYFAVLMQLSGDPVPAELQVPLEYISFVGCSISIVASLLTILLYAQSRKQSDSTTRIHMNLNGSVLLLNVTFLLSSQMTLPTMPRPVCKVLAAVLHYALLSSLTWMAIEGFNLYLFLGRVYNAYIRRYLLKLCMLGWGFPALLVLLLLMIKSSVYGPCVTSLSKSQENGTGFQNVSMCWIRSPMVHSILVMGYGGFTSLFNLVVLAWALWILCRLRAREKALSPWAYRDTAMVLGLTVLLGTTWTLAFFSFGVFLLPQLFLFTIFNSLYGFFLFLWFCSQKRYSDAEAKAEMEAVSSSQMTH
uniprot
proteins
function
FUNCTION: Orphan adhesion G protein-coupled receptor (aGPCR) (PubMed:22575658). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:22575658). ADGRG5 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:22575658). {ECO:0000269|PubMed:22575658}.; FUNCTION: [Isoform 1]: Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking). {ECO:0000269|PubMed:26499266}.
uniprot
proteins
mass_dalton
58675
uniprot
proteins
mutagenesis
MUTAGEN 222; /note="Missing: Drastic decrease in basal cAMP production."; /evidence="ECO:0000269|PubMed:26499266"; MUTAGEN 230; /note="Q->A,C,D,E,G,F,H,I,L,M,P,W,Y: Drastic reduction in basal cAMP production."; /evidence="ECO:0000269|PubMed:26499266"; MUTAGEN 230; /note="Q->K,N,R,S: No effect on basal cAMP production."; /evidence="ECO:0000269|PubMed:26499266"; MUTAGEN 230; /note="Q->T,V: Small reduction in basal cAMP production."; /evidence="ECO:0000269|PubMed:26499266
uniprot
proteins
post_translational_modification
PTM: Autoproteolytically processed at the GPS region of the GAIN-B domain; this cleavage modulates receptor activity. {ECO:0000250|UniProtKB:Q8IZF4, ECO:0000255|PROSITE-ProRule:PRU00098}.
uniprot
proteins
protein_family
Adhesion G protein-coupled receptor (ADGR) subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22575658
uniprot
proteins
pubmed
25713288
uniprot
proteins
pubmed
26499266
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26499266}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 247..267; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 285..305; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 320..340; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 352..372; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 414..434; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 454..476; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 481..500; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins