RAB11B
entrez
9230
canonical
uniprot
Q15907
canonical
ensembl
ENSG00000185236
resolver
ensp
ENSP00000333547
resolver
genesymbol
RAB11B
resolver
genesymbol_syn
YPT3
resolver
hgnc
HGNC:9761
resolver
uniprot
A5YM50
resolver
uniprot
B2R7I4
resolver
uniprot
B4DMK0
resolver
uniprot
D6W671
resolver
uniprot
Q2YDT2
resolver
uniprot
Q5U0I1
resolver
uniprot
Q6FHR0
resolver
uniprot
Q6FI42
resolver
uniprot
Q8NI07
resolver
uniprot_entry
RB11B_HUMAN
resolver
uniprot_sec
A5YM50
resolver
uniprot_sec
B2R7I4
resolver
uniprot_sec
B4DMK0
resolver
uniprot_sec
D6W671
resolver
uniprot_sec
Q2YDT2
resolver
uniprot_sec
Q5U0I1
resolver
uniprot_sec
Q6FHR0
resolver
uniprot_sec
Q6FI42
resolver
uniprot_sec
Q8NI07
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP (Probable). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation (Probable). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNNLSFIETSALDSTNVEEAFKNILTEIYRIVSQKQIADRAAHDESPGNNVVDISVPPTTDGQKPNKLQCCQNL
uniprot
proteins
disease_involvement
DISEASE: Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter (NDAGSCW) [MIM:617807]: An autosomal dominant neurodevelopmental disorder apparent in infancy and characterized by severe intellectual disability with absent speech, epilepsy, and hypotonia. Additionally, visual problems, musculoskeletal abnormalities, and microcephaly can be present. Brain imaging shows decreased cortical white matter, often with decreased cerebellar white matter, thin corpus callosum, and thin brainstem. {ECO:0000269|PubMed:29106825}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:14627637, PubMed:19029296, PubMed:19244346, PubMed:20717956, PubMed:21248079, PubMed:22129970, PubMed:26032412). RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis (PubMed:14627637, PubMed:19029296, PubMed:19244346, PubMed:20717956, PubMed:21248079, PubMed:22129970). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). Also interacts with RABL3 to promote ciliary vesicle formation (PubMed:36052645). {ECO:0000269|PubMed:14627637, ECO:0000269|PubMed:19029296, ECO:0000269|PubMed:19244346, ECO:0000269|PubMed:20717956, ECO:0000269|PubMed:21248079, ECO:0000269|PubMed:22129970, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26032412, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:36052645}.
uniprot
proteins
mass_dalton
24489
uniprot
proteins
mutagenesis
MUTAGEN 25; /note="S->N: Dominant negative mutant locked in the inactive GDP-bound form; alters apical recycling. Does not interact with ZFYV2E and KIF5A."; /evidence="ECO:0000269|PubMed:19244346, ECO:0000269|PubMed:21976701"; MUTAGEN 70; /note="Q->L: Constitutively active mutant locked in the active GTP-bound form; alters apical recycling."; /evidence="ECO:0000269|PubMed:19244346
uniprot
proteins
post_translational_modification
PTM: Citrullinated by PADI4. {ECO:0000250|UniProtKB:P46638}.; PTM: (Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3. {ECO:0000269|PubMed:32974215}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11495908
uniprot
proteins
pubmed
14627637
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16545962
uniprot
proteins
pubmed
19029296
uniprot
proteins
pubmed
19244346
uniprot
proteins
pubmed
20717956
uniprot
proteins
pubmed
21248079
uniprot
proteins
pubmed
21255211
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21976701
uniprot
proteins
pubmed
22129970
uniprot
proteins
pubmed
22613832
uniprot
proteins
pubmed
23572552
uniprot
proteins
pubmed
24023390
uniprot
proteins
pubmed
25673879
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26032412
uniprot
proteins
pubmed
29106825
uniprot
proteins
pubmed
30661770
uniprot
proteins
pubmed
31204173
uniprot
proteins
pubmed
32974215
uniprot
proteins
pubmed
36052645
uniprot
proteins
pubmed
7811277
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:P46638}; Lipid-anchor {ECO:0000250|UniProtKB:P46638}; Cytoplasmic side {ECO:0000250|UniProtKB:P46638}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O35509}; Lipid-anchor {ECO:0000250|UniProtKB:O35509}; Cytoplasmic side {ECO:0000250|UniProtKB:O35509}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305|PubMed:21255211}; Lipid-anchor {ECO:0000305|PubMed:21255211}; Cytoplasmic side {ECO:0000305|PubMed:21255211}. Cytoplasmic vesicle {ECO:0000269|PubMed:26032412}. Note=Recruited to phagosomes containing S.aureus. Colocalizes with RAB11AFIP1 on punctate vesicles (PubMed:26032412). {ECO:0000269|PubMed:26032412, ECO:0000305|PubMed:21255211}.
uniprot
proteins