Smg7
entrez
226517
canonical
uniprot
Q5RJH6
canonical
ensembl
ENSMUSG00000042772
resolver
ensp
ENSMUSP00000041241
resolver
ensp
ENSMUSP00000073144
resolver
ensp
ENSMUSP00000107467
resolver
ensp
ENSMUSP00000299483
resolver
ensp
ENSMUSP00000299484
resolver
genesymbol
Smg7
resolver
genesymbol_syn
Est1c
resolver
genesymbol_syn
Kiaa0250
resolver
uniprot
Q63ZW5
resolver
uniprot
Q6ZQF3
resolver
uniprot_entry
SMG7_MOUSE
resolver
uniprot_sec
Q63ZW5
resolver
uniprot_sec
Q6ZQF3
resolver
amino_acid_sequence
MSLQSAQYLRQAEVLKAEMTDSKLGPAEVWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQTHSSTIVKPQSSSCSYICQHCLVHLGDIARYRNQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDELKTKWGVSDFIKAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLLFQKAFNSQQLVHVTVINLFQLHHLRDFSNETEQHSYSQDEQLCWTQLLALFMSFLGILCKCPLQNDSQESNNAYPLPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLNSFHPREDDLSNTNATPLPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQQRRIRQQRLISIGKWIADNQPRLIQCENEVGKLLFITEIPELILEDPSEAKENLILQETSVVESLATDGSPGLKSVLSTGRNPSNSCDSGEKPVVTFKENIKPREVNQGRSFPPKEVKSQTELRKTPVSEARKTPVTQTPSQTSNSQFIPIHHPGAFPPLPSRPGFPPPTYVIPPPVAFSMGSGYTFPAGVSVPGTFLQSTAHSPAGNQVQAGKQSHIPYSQQRPSGPGPMNQGPQQSQPPSQPPLTSLPAQPTAQSTSQLQVQALAQQQQSPTKVIPALGKSPPHHSGFQQYQQADASKQLWNPPQVQSPLGKIMPVKQSYYLQTQDPIKLFEPSLQPPVIQQQPLEKKMKPFPMEPYNHNPSEVKVPEFYWDSSYSMADNRAVMAQQPNMDRRSKRSPGVFRPEQDPVPRMPFEDPKSSPLLPPDLLKSLAALEEEEELIFSNPPDLYPALLGPLASLPGRSLFKSLLEKPSELMSHSSSFLSLTGFSVNQERYPNSSMFNEVYGKNLTTSSKAELNPSVASQETSLYSLFEGTPWSPSLPASSDHSTPASQSPHSSNPSSLPSSPPTHNHNSAPFSNFGPIGTPDNRDRRPADRWKTDKPAMGGFGVDYLSATSSSESSWHQASTPSGTWTGHGPSMEDSSAVLMESLKSIWSSSMMHPGPSALEQLLMQQKQKQQRGQGAMNPPH
uniprot
proteins
function
FUNCTION: Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
126841
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
1138
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q92540}. Nucleus {ECO:0000250|UniProtKB:Q92540}. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. {ECO:0000250|UniProtKB:Q92540}.
uniprot
proteins