Ikzf2
entrez
22779
canonical
uniprot
P81183
canonical
ensembl
ENSMUSG00000025997
resolver
ensp
ENSMUSP00000027146
resolver
ensp
ENSMUSP00000139543
resolver
ensp
ENSMUSP00000226602
resolver
ensp
ENSMUSP00000226603
resolver
ensp
ENSMUSP00000226604
resolver
ensp
ENSMUSP00000226605
resolver
ensp
ENSMUSP00000226606
resolver
ensp
ENSMUSP00000226607
resolver
enst
ENSMUST00000190771
resolver
genesymbol
Ikzf2
resolver
genesymbol_syn
Helios
resolver
genesymbol_syn
Zfpn1a2
resolver
genesymbol_syn
Znfn1a2
resolver
uniprot
A0A087WNY4
resolver
uniprot
Q8C8A3
resolver
uniprot_entry
A0A087WNY4_MOUSE
resolver
uniprot_entry
IKZF2_MOUSE
resolver
uniprot_sec
Q8C8A3
resolver
amino_acid_sequence
METDAIDGYITCDNELSPEGEHANMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRQPLSREDEIRGHDEGSSLEEPLIESSEVADNRKVQDLQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVIEKLTANMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHAPSTIAEVAPVISSAYSQVYHPNRIERPISRETSDSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDRQSYQGNPALNPKRKQSPAYMKEDVKALDATKAPKGSLKDIYKVFNGEGEQIRAFKCEHCRVLFLDHVMYTIHMGCHGYRDPLECNICGYRSQDRYEFSSHIVRGEHTFH
uniprot
proteins
function
FUNCTION: Transcription factor, which stabilizes the noninflammatory phenotype of regulatory T cells (Tregs). Therefore plays a crucial role in self-tolerance (PubMed:26472910). May possibly act via STAT5-mediated signaling (PubMed:26472910). Binds IL2 promoter and represses its transcription, possibly by epigenetic silencing, inducing deacetylation of core histones in the IL2 promoter (PubMed:23275607). In Tregs, required for FOXP3 recruitment to the IL2 promoter (PubMed:23275607). Required for outer hair cells maturation and, consequently, for hearing (PubMed:30464345). {ECO:0000269|PubMed:23275607, ECO:0000269|PubMed:26472910, ECO:0000269|PubMed:30464345}.
uniprot
proteins
mass_dalton
59401
uniprot
proteins
mutagenesis
MUTAGEN 517; /note="H->Q: In cello; cello mice have progressive deterioration of hearing. Results in impaired OHC electromotility. Impaired homodimerization. No effect on nuclear localization."; /evidence="ECO:0000269|PubMed:30464345
uniprot
proteins
protein_family
Ikaros C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19620299
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23275607
uniprot
proteins
pubmed
26472910
uniprot
proteins
pubmed
30464345
uniprot
proteins
pubmed
9512513
uniprot
proteins
sequence_length
526
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30464345, ECO:0000269|PubMed:9512513}. Note=Associates with Ikaros at centromeric heterochromatin in T-cell nuclei. {ECO:0000269|PubMed:9512513}.
uniprot
proteins