Tac4
entrez
93670
canonical
uniprot
Q99N14
canonical
ensembl
ENSMUSG00000020872
resolver
ensp
ENSMUSP00000021242
resolver
enst
ENSMUST00000021242
resolver
genesymbol
Tac4
resolver
uniprot_entry
TKN4_MOUSE
resolver
amino_acid_sequence
MLPLLALLLLIGPSVCTTAGDREELAFGAEAESWVTVNLKGIPVPSIELKLQELKRSRTRQFYGLMGKRVGGYQLGRIVQDLLGTRGLSIEGTCRQAASQQRARPGAVTRESLQSREEDEAPLTTSNV
uniprot
proteins
function
FUNCTION: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Hemokinin induces plasma extravasation, mast cell degranulation, muscle contraction, salivary secretion and scratching behavior. Increases sperm motility. Induces potent analgesic effects and may play a role in pain modulation. Promotes survival of bone marrow B lineage cells and of cultured LPS-stimulated pre-B cells and may act as an autocrine factor required for B-cell survival and proliferation. Lowers systemic arterial pressure following intravenous injection. Induces interferon-gamma production and may play a role in the inflammatory response. Shows potent affinity and specificity for the NK-1 receptor. {ECO:0000269|PubMed:11062498, ECO:0000269|PubMed:11725292, ECO:0000269|PubMed:11786503, ECO:0000269|PubMed:12044836, ECO:0000269|PubMed:12842130, ECO:0000269|PubMed:15153465, ECO:0000269|PubMed:16102736, ECO:0000269|PubMed:17628523}.
uniprot
proteins
mass_dalton
13937
uniprot
proteins
protein_family
Tachykinin family
uniprot
proteins
pubmed
11062498
uniprot
proteins
pubmed
11725292
uniprot
proteins
pubmed
11786503
uniprot
proteins
pubmed
12044836
uniprot
proteins
pubmed
12383518
uniprot
proteins
pubmed
12716968
uniprot
proteins
pubmed
12842130
uniprot
proteins
pubmed
15153465
uniprot
proteins
pubmed
15342200
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15647454
uniprot
proteins
pubmed
16102736
uniprot
proteins
pubmed
17628523
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
128
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins