Gga1
entrez
106039
canonical
uniprot
Q8R0H9
canonical
ensembl
ENSMUSG00000033128
resolver
ensp
ENSMUSP00000035992
resolver
ensp
ENSMUSP00000311031
resolver
enst
ENSMUST00000041587
resolver
genesymbol
Gga1
resolver
uniprot
Q3U2N1
resolver
uniprot_entry
GGA1_MOUSE
resolver
uniprot_sec
Q3U2N1
resolver
amino_acid_sequence
MEPAMEPETLEARINRATNPLNKELNWASINSFCEQLNEDFEGPPLATRLLAHKIQSPQEWEAIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKSKILELLYSWTVCLPEEVKIAEAYQMLKKQGIVKSDPKLPEDAIFPLPPPRPKNVIFEDEEKSKMLARLLKSSHPEDLRAANKLIKEMVQEDQKRMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGAASSSSEDLMKELYQRCERMRPTLFRLASDTEDNDEALAEILQANDNLTQVINLYKQLVRGEEVNGDATASSIPGSTSALLDLSGLDLPPPGTTQPATPTRPGNQSSPEQLSASVSLLDDELMSLGLSDPTPPSGTSSDSVGWDNFQSSDGTESSVPPPAQAPSMDCRPPAQAPPPTSSGLDDLDLLGKTLMQQALPPEAQQVRWEKQQPAPRLTLRDLQSKSSSPSPGAASLLHTTSPEPPGPPPQATPTEFSLTSITVPLESIKPSSILPVTVYDQHGFRVLFHFARDPLPGRSDVLVVVVSMLSTAPQPIRNIVFQSAVPKVMKVRLQPPSGTELPAFNPIVHPSAITQVLLLANPQKEKVRLRYKLIFTMGDQTYNEMGDVDQFPPPETWGSL
uniprot
proteins
function
FUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes (PubMed:25405894). Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface (By similarity). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (PubMed:25405894). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (By similarity). {ECO:0000250|UniProtKB:Q9UJY5, ECO:0000269|PubMed:25405894}.
uniprot
proteins
mass_dalton
69972
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CK2 and dephosphorylated by PP2A. Phosphorylation of GGA1 allows the internal DXXLL motif to bind the VHS domain and to inhibit the recognition of cargo signals.; PTM: Ubiquitinated. {ECO:0000250|UniProtKB:Q9UJY5}.
uniprot
proteins
protein_family
GGA protein family
uniprot
proteins
pubmed
11950392
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19864490
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22522702
uniprot
proteins
pubmed
25405894
uniprot
proteins
sequence_length
635
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9UJY5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UJY5}. Endosome membrane {ECO:0000250|UniProtKB:Q9UJY5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UJY5}. Early endosome membrane {ECO:0000250|UniProtKB:Q9UJY5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UJY5}.
uniprot
proteins