Gucy1b2
entrez
239134
canonical
uniprot
Q8BXH3
canonical
ensembl
ENSMUSG00000021933
resolver
ensp
ENSMUSP00000022501
resolver
ensp
ENSMUSP00000128114
resolver
enst
ENSMUST00000022501
resolver
enst
ENSMUST00000165651
resolver
genesymbol
Gucy1b2
resolver
uniprot
E9Q6H0
resolver
uniprot
F6S2Y8
resolver
uniprot_entry
E9Q6H0_MOUSE
resolver
uniprot_entry
F6S2Y8_MOUSE
resolver
uniprot_entry
Q8BXH3_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activity is highly induced by nitric oxide. {ECO:0000250|UniProtKB:P22717}.
uniprot
proteins
amino_acid_sequence
MVMSEVLCAEYTLKVKMSDTADGVLYEPLRAEFRSKRTHLQGSAEGRGQFLASLQSTSTAFQRFGKTPGVQLRPGDTTLDTMYGFINTCLQSLVTEKFGEETWEKLKASAEVQDVFMTYTVYDDTITVKLIQEACKALDVSMEAILKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRVEGGADGAMRLHYYSDRRGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVFLVVQKARRQIRGAKVNRPRDSENIQAKQESLQGTLLRKKERYLSIPVCPGEKSHSAVVRASVLLGKGPLGDTFQPVFPERLWIEEEVFCNAFPFHVVFDEALRVKQAGVNIQKYVPGILTQKFGLDEYFSIVHPQVTFNISSICKFINSQFILKTRREMMPEAWKSQPTLKLRGQMIWMESLKCMVFMCSPKLRSLQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVLSNHLAIEKKKTETLLYAMLPEHVANQLKEGKKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTNIHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVTGEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAHRALENKGFEIVTRGEIEVKGKGKMTTYFLIRNLNATEVEIMGRPSALADGKEASTPRNQVKKPRAVLSNMDHHQQQVYNSDPADASDEVTLAGSPVAGRDDTDAVNSQSSPDETKTSAFASDPVLSAFCAVL
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Soluble guanylate cyclase that catalyzes the conversion of GTP to cGMP, likely through a heme-containing domain that senses molecular oxygen (By similarity). Expressed in a subpopulation of sensory neurons in the main olfactory epithelium (type B cells) coexpressing the cation channel TRPC2. Required for Ca(2+) influx in response to low environmental oxygen and hydrogen sulfide, acting upstream of cGMP-dependent protein kinase (PKG) and TRPC2. Mediates conditioned place aversion to hypoxic environments (PubMed:27916458, PubMed:34186026). {ECO:0000250|UniProtKB:P22717, ECO:0000269|PubMed:27916458, ECO:0000269|PubMed:34186026}.
uniprot
proteins
mass_dalton
92227
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
25701815
uniprot
proteins
pubmed
27916458
uniprot
proteins
pubmed
34186026
uniprot
proteins
sequence_length
824
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendrite {ECO:0000269|PubMed:34186026}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P22717}.
uniprot
proteins