CACYBP
entrez
27101
canonical
uniprot
Q9HB71
canonical
ensembl
ENSG00000116161
resolver
ensp
ENSP00000356652
resolver
ensp
ENSP00000479414
resolver
genesymbol
CACYBP
resolver
genesymbol_syn
S100A6BP
resolver
genesymbol_syn
SIP
resolver
hgnc
HGNC:30423
resolver
uniprot
B2ZWH2
resolver
uniprot
B3KSF1
resolver
uniprot
O60666
resolver
uniprot
Q5R370
resolver
uniprot
Q5R371
resolver
uniprot_entry
CYBP_HUMAN
resolver
uniprot_sec
B2ZWH2
resolver
uniprot_sec
B3KSF1
resolver
uniprot_sec
O60666
resolver
uniprot_sec
Q5R370
resolver
uniprot_sec
Q5R371
resolver
amino_acid_sequence
MASEELQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEIKNKMQQKSQKKAELLDNEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLTGVHQVPTENVQVHFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKVENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTEF
uniprot
proteins
function
FUNCTION: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). {ECO:0000269|PubMed:16085652}.
uniprot
proteins
mass_dalton
26210
uniprot
proteins
mutagenesis
MUTAGEN 23..26; /note="KRVR->AAVA: Abolishes interaction with SIAH1."; /evidence="ECO:0000269|PubMed:16085652"; MUTAGEN 64; /note="V->N: Abolishes interaction with SIAH1; when associated with N-66."; /evidence="ECO:0000269|PubMed:16085652"; MUTAGEN 66; /note="P->N: Abolishes interaction with SIAH1; when associated with N-64."; /evidence="ECO:0000269|PubMed:16085652
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations. {ECO:0000269|PubMed:12895292}.
uniprot
proteins
pubmed
11389839
uniprot
proteins
pubmed
12006993
uniprot
proteins
pubmed
12895292
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16085652
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
37316325
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12895292}. Cytoplasm {ECO:0000269|PubMed:12895292}. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.
uniprot
proteins