TCF7
entrez
6932
canonical
uniprot
P36402
canonical
ensembl
ENSG00000081059
resolver
ensp
ENSP00000340347
resolver
ensp
ENSP00000367822
resolver
ensp
ENSP00000378469
resolver
ensp
ENSP00000427870
resolver
ensp
ENSP00000429547
resolver
ensp
ENSP00000430179
resolver
ensp
ENSP00000521137
resolver
ensp
ENSP00000707212
resolver
ensp
ENSP00000707213
resolver
ensp
ENSP00000738837
resolver
genesymbol
TCF7
resolver
genesymbol_syn
TCF1
resolver
hgnc
HGNC:11639
resolver
uniprot
B3KQ75
resolver
uniprot
B3KSH3
resolver
uniprot
Q86WR9
resolver
uniprot
Q9UKI4
resolver
uniprot_entry
B3KQ75_HUMAN
resolver
uniprot_entry
TCF7_HUMAN
resolver
uniprot_sec
B3KSH3
resolver
uniprot_sec
Q86WR9
resolver
uniprot_sec
Q9UKI4
resolver
amino_acid_sequence
MPQLDSGGGGAGGGDDLGAPDELLAFQDEGEEQDDKSRDSAAGPERDLAELKSSLVNESEGAAGGAGIPGVPGAGAGARGEAEALGREHAAQRLFPDKLPEPLEDGLKAPECTSGMYKETVYSAFNLLMHYPPPSGAGQHPQPQPPLHKANQPPHGVPQLSLYEHFNSPHPTPAPADISQKQVHRPLQTPDLSGFYSLTSGSMGQLPHTVSWFTHPSLMLGSGVPGHPAAIPHPAIVPPSGKQELQPFDRNLKTQAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTGGKRNAFGTYPEKAAAPAPFLPMTVL
uniprot
proteins
function
FUNCTION: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. {ECO:0000250|UniProtKB:Q00417}.
uniprot
proteins
mass_dalton
41552
uniprot
proteins
protein_family
TCF/LEF family
uniprot
proteins
pubmed
10489374
uniprot
proteins
pubmed
11266540
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1569101
uniprot
proteins
pubmed
17218525
uniprot
proteins
pubmed
19304756
uniprot
proteins
pubmed
1989880
uniprot
proteins
pubmed
20028982
uniprot
proteins
pubmed
26079538
uniprot
proteins
pubmed
7640309
uniprot
proteins
pubmed
8622675
uniprot
proteins
pubmed
9488439
uniprot
proteins
pubmed
9783587
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins