Pak2
entrez
224105
canonical
uniprot
Q8CIN4
canonical
ensembl
ENSMUSG00000022781
resolver
ensp
ENSMUSP00000023467
resolver
ensp
ENSMUSP00000243872
resolver
enst
ENSMUST00000023467
resolver
genesymbol
Pak2
resolver
genesymbol_syn
mKIAA4182
resolver
uniprot
Q5DTJ2
resolver
uniprot_entry
PAK2_MOUSE
resolver
uniprot_entry
Q5DTJ2_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-402 and allows the kinase domain to adopt an active structure. Following caspase cleavage, autophosphorylated PAK-2p34 is constitutively active (By similarity). {ECO:0000250|UniProtKB:Q13177}.
uniprot
proteins
amino_acid_sequence
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRNKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNTKGSETSAVVTEEDDDDEDAAPPVIAPRPDHTKSIYTRSVIDPIPAPVGDSNVDSGAKSSDKQKKKAKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLILAAKEAMKSNR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:11278362). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (By similarity). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (By similarity). Full-length PAK2 stimulates cell survival and cell growth (By similarity). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (By similarity). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (By similarity). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:11278362). Phosphorylates CASP7, thereby preventing its activity (By similarity). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (By similarity). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (By similarity). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (By similarity). {ECO:0000250|UniProtKB:Q13177, ECO:0000269|PubMed:11278362}.
uniprot
proteins
mass_dalton
57930
uniprot
proteins
post_translational_modification
PTM: Full-length PAK2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both peptides, PAK-2p27 and PAK-2p34, become highly autophosphorylated. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and is dependent on phosphorylation of Thr-402, because PAK-2p27 is acting as an exogenous substrate (By similarity). {ECO:0000250|UniProtKB:Q13177}.; PTM: During apoptosis proteolytically cleaved by caspase-3 or caspase-3-like proteases to yield active PAK-2p34. {ECO:0000250|UniProtKB:Q13177}.; PTM: Ubiquitinated, leading to its proteasomal degradation. {ECO:0000250|UniProtKB:Q13177}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
11278362
uniprot
proteins
pubmed
12853446
uniprot
proteins
pubmed
14749374
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18716323
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Serine/threonine-protein kinase PAK 2]: Cytoplasm {ECO:0000250|UniProtKB:Q13177}. Nucleus {ECO:0000250|UniProtKB:Q13177}. Note=MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane. {ECO:0000250|UniProtKB:Q13177}.; SUBCELLULAR LOCATION: [PAK-2p34]: Nucleus {ECO:0000250|UniProtKB:Q13177}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q13177}. Membrane {ECO:0000250|UniProtKB:Q13177}; Lipid-anchor {ECO:0000250|UniProtKB:Q13177}. Note=Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane. {ECO:0000250|UniProtKB:Q13177}.
uniprot
proteins