Ppm1a
entrez
19042
canonical
uniprot
P49443
canonical
ensembl
ENSMUSG00000021096
resolver
ensp
ENSMUSP00000021514
resolver
ensp
ENSMUSP00000194475
resolver
enst
ENSMUST00000021514
resolver
genesymbol
Ppm1a
resolver
genesymbol_syn
Pp2ca3
resolver
genesymbol_syn
Pppm1a
resolver
uniprot
Q9EQE3
resolver
uniprot_entry
PPM1A_MOUSE
resolver
uniprot_entry
Q9EQE3_MOUSE
resolver
amino_acid_sequence
MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLETWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFRGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPSAPKVSAEAVKKEAELDKYLESRVEEIIKKQVEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNRLNPYKNDDTDSASTDDMW
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000250, ECO:0000269|PubMed:23088624}.
uniprot
proteins
mass_dalton
42433
uniprot
proteins
post_translational_modification
PTM: N-myristoylation is essential for the recognition of its substrates for dephosphorylation. {ECO:0000269|PubMed:23088624}.
uniprot
proteins
protein_family
PP2C family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22781750
uniprot
proteins
pubmed
23088624
uniprot
proteins
pubmed
8056349
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P35813}. Cytoplasm, cytosol {ECO:0000269|PubMed:22781750, ECO:0000269|PubMed:23088624}. Membrane {ECO:0000269|PubMed:23088624}; Lipid-anchor {ECO:0000269|PubMed:23088624}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000269|PubMed:23088624}.
uniprot
proteins