Bmp6
entrez
25644
canonical
uniprot
Q04906
canonical
ensembl
ENSRNOG00000013717
resolver
ensembl
ENSRNOG00065008388
resolver
ensp
ENSRNOP00000018359
resolver
ensp
ENSRNOP00065009839
resolver
enst
ENSRNOT00000018359
resolver
enst
ENSRNOT00065013296
resolver
genesymbol
Bmp6
resolver
genesymbol_syn
Bmp-6
resolver
genesymbol_syn
Vgr
resolver
uniprot
Q811S4
resolver
uniprot_entry
BMP6_RAT
resolver
uniprot_sec
Q811S4
resolver
amino_acid_sequence
MPGLGRRAQWLCWWWGLLCSCGPPPLRPPLPVAAAAAGGQLLGAGGSPVRAEQPPPQSSSSGFLYRRLKTHEKREMQKEILSVLGLPHRPRPLHGLQQPQSPVLPQQQQSQQTAREEPPPGRLKSAPLFMLDLYNSLSKDDEEDGVSEGEGLEPESHGRASSSQLKQPSPGAAHSLNRKSLLAPGPGGSASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEAVTAAEFRVYKDCVVGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGLHINPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVSRGSSASDYNSSELKTACKKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH
uniprot
proteins
function
FUNCTION: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation (By similarity). Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV (By similarity). Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3 (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression (By similarity). {ECO:0000250|UniProtKB:P20722, ECO:0000250|UniProtKB:P22004}.
uniprot
proteins
mass_dalton
56223
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
1453478
uniprot
proteins
sequence_length
506
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins