SLC25A39
entrez
51629
canonical
uniprot
Q9BZJ4
canonical
ensembl
ENSG00000013306
resolver
ensp
ENSP00000225308
resolver
ensp
ENSP00000366299
resolver
ensp
ENSP00000444540
resolver
ensp
ENSP00000466615
resolver
ensp
ENSP00000466676
resolver
ensp
ENSP00000573307
resolver
ensp
ENSP00000573315
resolver
ensp
ENSP00000573321
resolver
ensp
ENSP00000596157
resolver
ensp
ENSP00000625495
resolver
ensp
ENSP00000702255
resolver
ensp
ENSP00000702263
resolver
enst
ENST00000537904
resolver
enst
ENST00000903248
resolver
enst
ENST00000903256
resolver
enst
ENST00000903262
resolver
enst
ENST00000926098
resolver
enst
ENST00000955436
resolver
genesymbol
SLC25A39
resolver
hgnc
HGNC:24279
resolver
uniprot
A0ACI8RHK7
resolver
uniprot
A8JZZ2
resolver
uniprot
B4DFG5
resolver
uniprot
D3DX51
resolver
uniprot
D3DX54
resolver
uniprot
Q4V9M1
resolver
uniprot
Q9P182
resolver
uniprot
Q9UF66
resolver
uniprot
Q9Y379
resolver
uniprot_entry
A0ACI8RHK7_HUMAN
resolver
uniprot_entry
B4DFG5_HUMAN
resolver
uniprot_entry
S2539_HUMAN
resolver
uniprot_sec
A8JZZ2
resolver
uniprot_sec
D3DX51
resolver
uniprot_sec
D3DX54
resolver
uniprot_sec
Q4V9M1
resolver
uniprot_sec
Q9P182
resolver
uniprot_sec
Q9UF66
resolver
uniprot_sec
Q9Y379
resolver
activity_regulation
ACTIVITY REGULATION: The activity of SLC25A39 is regulated by levels of mitochondrial glutathione via its ability to bind [2Fe-2S] iron-sulfur cluster (PubMed:37917749, PubMed:38157846). Upon physiological levels of mitochondrial glutathione, glutathione prevents iron-sulfur-binding to SLC25A39 promoting cleavage and degradation by AFG3L2 (PubMed:37917749, PubMed:38157846). Upon depletion of mitochondrial glutathione, SLC25A39 binds iron-sulfur, preventing cleavage and degradation by AFG3L2 (PubMed:37917749, PubMed:38157846). {ECO:0000269|PubMed:37917749, ECO:0000269|PubMed:38157846}.
uniprot
proteins
amino_acid_sequence
MADQDPAGISPLQQMVASGTGAVVTSLFMTPLDVVKVRLQSQRPSMASELMPSSRLWSLSYTKLPSSLQSTGKCLLYCNGVLEPLYLCPNGARCATWFQDPTRFTGTMDAFVKIVRHEGTRTLWSGLPATLVMTVPATAIYFTAYDQLKAFLCGRALTSDLYAPMVAGALARLGTVTVISPLELMRTKLQAQHVSYRELGACVRTAVAQGGWRSLWLGWGPTALRDVPFSALYWFNYELVKSWLNGFRPKDQTSVGMSFVAGGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRVNPLHVDSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIMISTYEFGKSFFQRLNQDRLLGG
uniprot
proteins
function
FUNCTION: Mitochondrial transporter required for glutathione import into mitochondria (PubMed:34707288, PubMed:35513392, PubMed:37917749, PubMed:38157846). Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (PubMed:34707288). Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis (PubMed:34707288). {ECO:0000269|PubMed:34707288, ECO:0000269|PubMed:35513392, ECO:0000269|PubMed:37917749, ECO:0000269|PubMed:38157846}.
uniprot
proteins
mass_dalton
39249
uniprot
proteins
mutagenesis
MUTAGEN 74..94; /note="CLLYCNGVLEPLYLCPNGARC->ALLYANGVLEPLYLAPNGARA,SLLYSNGVLEPLYLSPNGARS: Abolished binding to [2Fe-2S] cluster, promoting degradation by AFG3L2."; /evidence="ECO:0000269|PubMed:37917749, ECO:0000269|PubMed:38157846"; MUTAGEN 226; /note="D->A: Abolished glutathione import into mitochondria without affecting the levels of NAD."; /evidence="ECO:0000269|PubMed:34707288, ECO:0000269|PubMed:35513392"; MUTAGEN 329; /note="K->A: Abolished glutathione import into mitochondria without affecting the levels of NAD."; /evidence="ECO:0000269|PubMed:34707288
uniprot
proteins
post_translational_modification
PTM: Cleaved and degraded by AFG3L2; degradation by AFG3L2 is regulated by the ability of SLC25A39 to bind iron-sulfur (PubMed:37917749, PubMed:38157846). In absence of mitochondrial glutathione, SLC25A39 binds iron-sulfur, preventing cleavage and degradation by AFG3L2 (PubMed:37917749, PubMed:38157846). The presence of mitochondrial glutathione prevents iron-sulfur-binding to SLC25A39, promoting cleavage and degradation by AFG3L2 (PubMed:37917749, PubMed:38157846). {ECO:0000269|PubMed:37917749, ECO:0000269|PubMed:38157846}.
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11139402
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11256614
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
34707288
uniprot
proteins
pubmed
35513392
uniprot
proteins
pubmed
37917749
uniprot
proteins
pubmed
38157846
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11139402, ECO:0000269|PubMed:11256614, ECO:0000269|PubMed:37917749}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..35; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 122..142; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 215..235; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 259..279; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 318..338; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins