TP53I3
entrez
9540
canonical
uniprot
Q53FA7
canonical
ensembl
ENSG00000115129
resolver
ensp
ENSP00000238721
resolver
ensp
ENSP00000337834
resolver
ensp
ENSP00000384414
resolver
genesymbol
TP53I3
resolver
genesymbol_syn
PIG3
resolver
hgnc
HGNC:19373
resolver
uniprot
B4DMQ7
resolver
uniprot
D6W533
resolver
uniprot
O14679
resolver
uniprot
O14685
resolver
uniprot
Q38G78
resolver
uniprot
Q6JLE7
resolver
uniprot
Q9BWB8
resolver
uniprot_entry
B4DMQ7_HUMAN
resolver
uniprot_entry
QORX_HUMAN
resolver
uniprot_sec
D6W533
resolver
uniprot_sec
O14679
resolver
uniprot_sec
O14685
resolver
uniprot_sec
Q38G78
resolver
uniprot_sec
Q6JLE7
resolver
uniprot_sec
Q9BWB8
resolver
amino_acid_sequence
MLAVHFDKPGGPENLYVKEVAKPSPGEGEVLLKVAASALNRADLMQRQGQYDPPPGASNILGLEASGHVAELGPGCQGHWKIGDTAMALLPGGGQAQYVTVPEGLLMPIPEGLTLTQAAAIPEAWLTAFQLLHLVGNVQAGDYVLIHAGLSGVGTAAIQLTRMAGAIPLVTAGSQKKLQMAEKLGAAAGFNYKKEDFSEATLKFTKGAGVNLILDCIGGSYWEKNVNCLALDGRWVLYGLMGGGDINGPLFSKLLFKRGSLITSLLRSRDNKYKQMLVNAFTEQILPHFSTEGPQRLLPVLDRIYPVTEIQEAHKYMEANKNIGKIVLELPQ
uniprot
proteins
ec_number
1.6.5.5
uniprot
proteins
function
FUNCTION: NADPH:quinone reductase which expression is induced by p53/TP53 and is involved in both the DNA damage response through homologous recombination repair, and p53-mediated apoptosis (PubMed:19349281, PubMed:33782397). Catalyzes the NADPH-dependent reduction of quinones, exhibiting a low enzymatic activity with beta-naphthoquinones and a strong preference for the ortho-quinone isomer (1,2-beta-naphthoquinone) over the para isomer (1,4-beta-naphthoquinone). Also displays a low reductase activity for non-quinone compounds such as diamine and 2,6-dichloroindophenol (in vitro) (PubMed:19349281). The reduction of 1,2-naphthoquinone concurrently generates reactive oxygen species (ROS), which may trigger apoptosis downstream of p53/TP53 (PubMed:19349281). {ECO:0000269|PubMed:19349281, ECO:0000269|PubMed:33782397}.
uniprot
proteins
mass_dalton
35536
uniprot
proteins
mutagenesis
MUTAGEN 51; /note="Y->A: Loss of NADPH:quinone reductase activity."; /evidence="ECO:0000269|PubMed:19349281"; MUTAGEN 51; /note="Y->F: Increased NADPH:quinone reductase activity."; /evidence="ECO:0000269|PubMed:19349281"; MUTAGEN 151; /note="S->V: Loss of NADPH:quinone reductase activity."; /evidence="ECO:0000269|PubMed:19349281
uniprot
proteins
protein_family
Quinone oxidoreductase subfamily
uniprot
proteins
protein_family
Zinc-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
15067011
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17224074
uniprot
proteins
pubmed
19349281
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
33782397
uniprot
proteins
pubmed
9305847
uniprot
proteins
sequence_length
332
uniprot
proteins