Csf1
entrez
12977
canonical
uniprot
P07141
canonical
ensembl
ENSMUSG00000014599
resolver
ensp
ENSMUSP00000014743
resolver
ensp
ENSMUSP00000113136
resolver
ensp
ENSMUSP00000113617
resolver
ensp
ENSMUSP00000304916
resolver
genesymbol
Csf1
resolver
genesymbol_syn
Csfm
resolver
uniprot
Q3U395
resolver
uniprot
Q8R3C8
resolver
uniprot_entry
CSF1_MOUSE
resolver
uniprot_sec
Q3U395
resolver
uniprot_sec
Q8R3C8
resolver
amino_acid_sequence
MTARGAAGRCPSSTWLGSRLLLVCLLMSRSIAKEVSEHCSHMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFFLVQDIIDETMRFKDNTPNANATERLQELSNNLNSCFTKDYEEQNKACVRTFHETPLQLLEKIKNFFNETKNLLEKDWNIFTKNCNNSFAKCSSRDVVTKPDCNCLYPKATPSSDPASASPHQPPAPSMAPLAGLAWDDSQRTEGSSLLPSELPLRIEDPGSAKQRPPRSTCQTLESTEQPNHGDRLTEDSQPHPSAGGPVPGVEDILESSLGTNWVLEEASGEASEGFLTQEAKFSPSTPVGGSIQAETDRPRALSASPFPKSTEDQKPVDITDRPLTEVNPMRPIGQTQNNTPEKTDGTSTLREDHQEPGSPHIATPNPQRVSNSATPVAQLLLPKSHSWGIVLPLGELEGKRSTRDRRSPAELEGGSASEGAARPVARFNSIPLTDTGHVEQHEGSSDPQIPESVFHLLVPGIILVLLTVGGLLFYKWKWRSHRDPQTLDSSVGRPEDSSLTQDEDRQVELPV
uniprot
proteins
disease_involvement
DISEASE: Note=A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling. {ECO:0000269|PubMed:2188141}.
uniprot
proteins
function
FUNCTION: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
uniprot
proteins
mass_dalton
60649
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P09603}.; PTM: O-glycosylated; contains chondroitin sulfate. {ECO:0000269|PubMed:1733926}.
uniprot
proteins
pubmed
12074592
uniprot
proteins
pubmed
12379742
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1733926
uniprot
proteins
pubmed
1874443
uniprot
proteins
pubmed
19017797
uniprot
proteins
pubmed
2188141
uniprot
proteins
pubmed
2457916
uniprot
proteins
pubmed
3493488
uniprot
proteins
pubmed
3494232
uniprot
proteins
pubmed
3925458
uniprot
proteins
pubmed
8357831
uniprot
proteins
sequence_length
552
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 493..515; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins