Myrip
entrez
245049
canonical
uniprot
Q8K3I4
canonical
ensembl
ENSMUSG00000041794
resolver
ensp
ENSMUSP00000046891
resolver
ensp
ENSMUSP00000315287
resolver
ensp
ENSMUSP00000315289
resolver
enst
ENSMUST00000048121
resolver
genesymbol
Myrip
resolver
genesymbol_syn
Slac2c
resolver
uniprot
A1L320
resolver
uniprot
A1L321
resolver
uniprot
Q8CFC0
resolver
uniprot
Q8K4H5
resolver
uniprot_entry
MYRIP_MOUSE
resolver
uniprot_sec
A1L320
resolver
uniprot_sec
A1L321
resolver
uniprot_sec
Q8CFC0
resolver
uniprot_sec
Q8K4H5
resolver
amino_acid_sequence
MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEDRLSEMKQRLAEENSKCSILSKHQKFVERCCMRCCSPFTFLVNARRRCGECKFSVCKSCCSYQKHEKLWVCCVCQQARLLRTQSLEWFYNNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGGLFEPNLENEGSISGSDSTFYRQSEGHSMMDTLAVALRVAEEAIEEAISKAESHGDSLDKQNEASYLRDHKQELTEELAGTILQRIIRKQKDKAELRAEEEEPEWPRSQSGSVKARGEGTTAPPGRHKARATFRRSQSAFSFTMEDALKSGSAEAAPRSPKDRAQRLLEEAALPSWRSMDGLDGTNLAPLLQSPDGNWMTLKDGSRQPPTRLLTKPKSGTFQALEVASSVTSAYDEIGSDSEEDFDYSEALSKLCPPSQSRLKQPQPQPTQAQSSGQGPLATSPSNPEAMCSDSETSSTSSSREAGCRAKLSWLQRKAPKNPAVEKMPLQGELDVNFNPQAAGGETSDSSDPEETLRTAERRARRWRRARVGPEESNRGLPSPGAHPRALHTAQVSDNVSETDISNETQNSRSSTDSVEEKLRNRLYELAMKMSEKETSSGEDQESESKAEPKNQKGSLSSEENNQGVQEELKKKCSAVSLCNISTEVLKVINATEELIAESAGPWEIPPVSTDRENGMFPLGTDQVRLDKQLTSLEENVYLAAGTVYGLEGQLSELEDAARCIHSSTGETELADLEDQVAAAAAQVHHAELQISDIESRISALTIAGLNIAPCVRLTRRRDQKQRSQVQTIDTSRQQRRKLPAPPVKAEKIEASSVTPIKTFNRNFLLQGSSTNRPTASTGDTKDLMEPDLESAVMY
uniprot
proteins
function
FUNCTION: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release. {ECO:0000269|PubMed:17827149}.
uniprot
proteins
mass_dalton
94924
uniprot
proteins
mutagenesis
MUTAGEN 197; /note="V->P: Loss of PRKAR2A-binding; when associated with P-206."; /evidence="ECO:0000269|PubMed:17827149"; MUTAGEN 206; /note="I->P: Loss of PRKAR2A-binding; when associated with P-197."; /evidence="ECO:0000269|PubMed:17827149"; MUTAGEN 236; /note="L->P: Increased PRKAR2A-binding; when associated with P-245."; MUTAGEN 245; /note="I->P: Increased PRKAR2A-binding; when associated with P-245.
uniprot
proteins
pubmed
11964381
uniprot
proteins
pubmed
12062444
uniprot
proteins
pubmed
12221080
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17827149
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
856
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12221080}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TNY7}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q7TNY7}. Melanosome {ECO:0000269|PubMed:11964381, ECO:0000269|PubMed:12221080}. Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments. In insulin-secreting cells, associated with dense core secretory granules. {ECO:0000269|PubMed:11964381, ECO:0000269|PubMed:12221080}.
uniprot
proteins