Slc7a6
entrez
307811
canonical
uniprot
D3ZMM8
canonical
ensembl
ENSRNOG00000019943
resolver
ensembl
ENSRNOG00055018321
resolver
ensembl
ENSRNOG00060012645
resolver
ensembl
ENSRNOG00065012197
resolver
ensp
ENSRNOP00000027117
resolver
ensp
ENSRNOP00000078355
resolver
ensp
ENSRNOP00055025066
resolver
ensp
ENSRNOP00060016984
resolver
ensp
ENSRNOP00065015198
resolver
enst
ENSRNOT00000027117
resolver
enst
ENSRNOT00000094705
resolver
enst
ENSRNOT00055031095
resolver
enst
ENSRNOT00060021487
resolver
enst
ENSRNOT00065019827
resolver
genesymbol
Slc7a6
resolver
uniprot
A0A8I5ZKR1
resolver
uniprot_entry
A0A8I5ZKR1_RAT
resolver
uniprot_entry
YLAT2_RAT
resolver
amino_acid_sequence
MEARELGSPTPTYHLLPKANQHTVKEDASSPSQGSPETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLKYTASYGLSLVVWAIGGLFSVVGALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLIVEPTSQAIIAITFANYIIKPSFPTCDPPYVACRLLAAACVCLLTFVNCAYVKWGTRVQDTFTYAKVLALIAIIIMGLVKLCQGHTEHFQDAFKGSSWNVGDLSLALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNIQDVHKSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPNLLSMIHIERFTPVPALLFNCTMTLIYLVVKDVFLLINYFSFSYWFFVGLSVVGQLYLRWKEPDWPRPLKLSLFFPIVFCICSLFLVAVPLFSDTINSLIGIGIALSGVPVYFMGVYLPEARRPLFIRKVLATVTRVTQKLCFCVLTELDVAEEKNVERKTD
uniprot
proteins
function
FUNCTION: Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux routeby exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:22401943, PubMed:26448619). Also exchanges L-arginine with L-lysine in a sodium-independent manner. The transport mechanism is electroneutral and operates with a stoichiometry of 1: 1 (By similarity). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (PubMed:22401943, PubMed:26448619). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (By similarity). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). {ECO:0000250|UniProtKB:Q8BGK6, ECO:0000250|UniProtKB:Q92536, ECO:0000269|PubMed:22401943, ECO:0000269|PubMed:26448619}.
uniprot
proteins
mass_dalton
56815
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
protein_family
L-type amino acid transporter (LAT) (TC 2.A.3.8) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22401943
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
26448619
uniprot
proteins
sequence_length
515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q92536}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..65; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 195..215; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 267..287; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 312..332; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 364..384; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 386..406; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 425..445; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 452..472; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins