ALDH3B1
entrez
221
canonical
uniprot
P43353
canonical
ensembl
ENSG00000006534
resolver
ensp
ENSP00000473990
resolver
ensp
ENSP00000478486
resolver
ensp
ENSP00000481604
resolver
ensp
ENSP00000484901
resolver
enst
ENST00000612297
resolver
genesymbol
ALDH3B1
resolver
genesymbol_syn
ALDH7
resolver
hgnc
HGNC:410
resolver
uniprot
A0A087X2D4
resolver
uniprot
A3FMP9
resolver
uniprot
Q53XL5
resolver
uniprot
Q8N515
resolver
uniprot
Q96CK8
resolver
uniprot_entry
A0A087X2D4_HUMAN
resolver
uniprot_entry
AL3B1_HUMAN
resolver
uniprot_sec
A3FMP9
resolver
uniprot_sec
Q53XL5
resolver
uniprot_sec
Q8N515
resolver
uniprot_sec
Q96CK8
resolver
amino_acid_sequence
MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL
uniprot
proteins
ec_number
1.2.1.28
uniprot
proteins
ec_number
1.2.1.48
uniprot
proteins
ec_number
1.2.1.5
uniprot
proteins
ec_number
1.2.1.7
uniprot
proteins
function
FUNCTION: Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids (PubMed:17382292, PubMed:23721920). May have a protective role against the cytotoxicity induced by lipid peroxidation (PubMed:17382292). Short-chain fatty aldehydes are not good substrates (PubMed:17382292). Can use both NADP(+) and NAD(+) as electron acceptor in vitro, however in vivo preference will depend on their tissue levels (PubMed:17382292). Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde (PubMed:17382292, PubMed:23721920). Able to metabolize aromatic aldehydes such as benzaldehyde to their acid form (PubMed:17382292). {ECO:0000269|PubMed:17382292, ECO:0000269|PubMed:23721920}.
uniprot
proteins
mass_dalton
51840
uniprot
proteins
pathway_participation
PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
uniprot
proteins
post_translational_modification
PTM: Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates. {ECO:0000269|PubMed:23721920}.
uniprot
proteins
protein_family
Aldehyde dehydrogenase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17382292
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23721920
uniprot
proteins
pubmed
7828891
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23721920}; Lipid-anchor {ECO:0000269|PubMed:23721920}. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.
uniprot
proteins