Il7
entrez
16196
canonical
uniprot
P10168
canonical
ensembl
ENSMUSG00000040329
resolver
ensp
ENSMUSP00000126219
resolver
ensp
ENSMUSP00000141508
resolver
ensp
ENSMUSP00000141827
resolver
ensp
ENSMUSP00000141845
resolver
enst
ENSMUST00000168269
resolver
enst
ENSMUST00000192202
resolver
enst
ENSMUST00000194184
resolver
enst
ENSMUST00000194279
resolver
genesymbol
Il7
resolver
genesymbol_syn
Il-7
resolver
uniprot
A0A0B4J1L9
resolver
uniprot
Q3UT18
resolver
uniprot
Q544C8
resolver
uniprot_entry
A0A0B4J1L9_MOUSE
resolver
uniprot_entry
IL7_MOUSE
resolver
uniprot_entry
Q3UT18_MOUSE
resolver
uniprot_entry
Q544C8_MOUSE
resolver
amino_acid_sequence
MFHVSFRYIFGIPPLILVLLPVTSSECHIKDKEGKAYESVLMISIDELDKMTGTDSNCPNNEPNFFRKHVCDDTKEAAFLNRAARKLKQFLKMNISEEFNVHLLTVSQGTQTLVNCTSKEEKNVKEQKKNDACFLKRLLREIKTCWNKILKGSI
uniprot
proteins
function
FUNCTION: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis (PubMed:28811625, PubMed:7699333). Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5. {ECO:0000250|UniProtKB:P13232, ECO:0000269|PubMed:28811625, ECO:0000269|PubMed:7699333}.
uniprot
proteins
mass_dalton
17727
uniprot
proteins
post_translational_modification
PTM: Three disulfide bonds are present. {ECO:0000305}.
uniprot
proteins
protein_family
IL-7/IL-9 family
uniprot
proteins
pubmed
2329282
uniprot
proteins
pubmed
28811625
uniprot
proteins
pubmed
3259677
uniprot
proteins
pubmed
7699333
uniprot
proteins
sequence_length
154
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P13232}.
uniprot
proteins