DHX58
entrez
79132
canonical
uniprot
Q96C10
canonical
ensembl
ENSG00000108771
resolver
ensp
ENSP00000251642
resolver
ensp
ENSP00000570755
resolver
ensp
ENSP00000570756
resolver
ensp
ENSP00000570758
resolver
ensp
ENSP00000624466
resolver
ensp
ENSP00000719849
resolver
ensp
ENSP00000719853
resolver
enst
ENST00000251642
resolver
enst
ENST00000900696
resolver
enst
ENST00000900697
resolver
enst
ENST00000900699
resolver
enst
ENST00000954407
resolver
genesymbol
DHX58
resolver
genesymbol_syn
D11LGP2E
resolver
genesymbol_syn
LGP2
resolver
hgnc
HGNC:29517
resolver
uniprot
A0AA51U9C6
resolver
uniprot
Q9HAM6
resolver
uniprot_entry
A0AA51U9C6_HUMAN
resolver
uniprot_entry
DHX58_HUMAN
resolver
uniprot_sec
Q9HAM6
resolver
amino_acid_sequence
MELRSYQWEVIMPALEGKNIIIWLPTGAGKTRAAAYVAKRHLETVDGAKVVVLVNRVHLVTQHGEEFRRMLDGRWTVTTLSGDMGPRAGFGHLARCHDLLICTAELLQMALTSPEEEEHVELTVFSLIVVDECHHTHKDTVYNVIMSQYLELKLQRAQPLPQVLGLTASPGTGGASKLDGAINHVLQLCANLDTWCIMSPQNCCPQLQEHSQQPCKQYNLCHRRSQDPFGDLLKKLMDQIHDHLEMPELSRKFGTQMYEQQVVKLSEAAALAGLQEQRVYALHLRRYNDALLIHDTVRAVDALAALQDFYHREHVTKTQILCAERRLLALFDDRKNELAHLATHGPENPKLEMLEKILQRQFSSSNSPRGIIFTRTRQSAHSLLLWLQQQQGLQTVDIRAQLLIGAGNSSQSTHMTQRDQQEVIQKFQDGTLNLLVATSVAEEGLDIPHCNVVVRYGLLTNEISMVQARGRARADQSVYAFVATEGSRELKRELINEALETLMEQAVAAVQKMDQAEYQAKIRDLQQAALTKRAAQAAQRENQRQQFPVEHVQLLCINCMVAVGHGSDLRKVEGTHHVNVNPNFSNYYNVSRDPVVINKVFKDWKPGGVISCRNCGEVWGLQMIYKSVKLPVLKVRSMLLETPQGRIQAKKWSRVPFSVPDFDFLQHCAENLSDLSLD
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Acts as a regulator of RIGI and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to RIGI and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on RIG-I signaling may involve the following mechanisms: competition with RIGI for binding to the viral RNA, binding to RIGI and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by RIGI and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses and coronavirus SARS-CoV-2, and also to the bacterial pathogen Listeria monocytogenes (PubMed:31256877). Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate. {ECO:0000269|PubMed:16116171, ECO:0000269|PubMed:17020950, ECO:0000269|PubMed:17190814, ECO:0000269|PubMed:18411269, ECO:0000269|PubMed:19208642, ECO:0000269|PubMed:19211564, ECO:0000269|PubMed:19278996, ECO:0000269|PubMed:19380577, ECO:0000269|PubMed:21187438, ECO:0000269|PubMed:21525357, ECO:0000269|PubMed:31256877}.
uniprot
proteins
mass_dalton
76613
uniprot
proteins
mutagenesis
MUTAGEN 30; /note="K->A: Loss of dsRNA-induced ATPase activity. No effect on ds-RNA binding. No effect on cytoplasmic pattern recognition receptor signaling pathway in response to virus."; /evidence="ECO:0000269|PubMed:19211564"; MUTAGEN 131..134; /note="DECH->AACA: Loss of dsRNA-induced ATPase activity."; /evidence="ECO:0000269|PubMed:19211564"; MUTAGEN 167..169; /note="TAS->AAA: Loss of dsRNA-induced ATPase activity. Loss of ds-RNA binding. No effect on cytoplasmic pattern recognition receptor signaling pathway in response to virus."; /evidence="ECO:0000269|PubMed:19211564"; MUTAGEN 373..376; /note="FTRT->ATRA: Loss of dsRNA-induced ATPase activity. No effect on cytoplasmic pattern recognition receptor signaling pathway in response to virus."; /evidence="ECO:0000269|PubMed:19211564"; MUTAGEN 438..442; /note="TSVAE->ASVAA: Loss of dsRNA-induced ATPase activity. No effect on cytoplasmic pattern recognition receptor signaling pathway in response to virus."; /evidence="ECO:0000269|PubMed:19211564"; MUTAGEN 467..471; /note="QARGR->AARGA: Loss of dsRNA-induced ATPase activity. No effect on cytoplasmic pattern recognition receptor signaling pathway in response to virus."; /evidence="ECO:0000269|PubMed:19211564"; MUTAGEN 634; /note="K->E: Abolishes RNA binding."; /evidence="ECO:0000269|PubMed:19208642, ECO:0000269|PubMed:19278996"; MUTAGEN 651; /note="K->E: Abolishes RNA binding."; /evidence="ECO:0000269|PubMed:19278996
uniprot
proteins
protein_family
Helicase family
uniprot
proteins
protein_family
RLR subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16116171
uniprot
proteins
pubmed
17020950
uniprot
proteins
pubmed
17190814
uniprot
proteins
pubmed
17473309
uniprot
proteins
pubmed
17709747
uniprot
proteins
pubmed
18411269
uniprot
proteins
pubmed
19208642
uniprot
proteins
pubmed
19211564
uniprot
proteins
pubmed
19278996
uniprot
proteins
pubmed
19380577
uniprot
proteins
pubmed
19403670
uniprot
proteins
pubmed
21187438
uniprot
proteins
pubmed
21481967
uniprot
proteins
pubmed
21496944
uniprot
proteins
pubmed
21525357
uniprot
proteins
pubmed
21616437
uniprot
proteins
pubmed
21791617
uniprot
proteins
pubmed
23711367
uniprot
proteins
pubmed
31256877
uniprot
proteins
pubmed
33440148
uniprot
proteins
sequence_length
678
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19380577}.
uniprot
proteins