Rhot1
entrez
303351
canonical
uniprot
A1L1L6
canonical
ensembl
ENSRNOG00000004093
resolver
ensp
ENSRNOP00000074094
resolver
ensp
ENSRNOP00000074726
resolver
ensp
ENSRNOP00000092578
resolver
ensp
ENSRNOP00000097730
resolver
ensp
ENSRNOP00000107396
resolver
enst
ENSRNOT00000079696
resolver
enst
ENSRNOT00000082685
resolver
enst
ENSRNOT00000108985
resolver
enst
ENSRNOT00000112911
resolver
enst
ENSRNOT00000137581
resolver
genesymbol
Rhot1
resolver
genesymbol_syn
Rnf135
resolver
uniprot
A0A0G2K777
resolver
uniprot
A0A0G2K8T2
resolver
uniprot
A0A8I6AGU0
resolver
uniprot
A0A8I6AVD9
resolver
uniprot_entry
A0A0G2K777_RAT
resolver
uniprot_entry
A0A0G2K8T2_RAT
resolver
uniprot_entry
A0A8I6AGU0_RAT
resolver
uniprot_entry
A0A8I6AVD9_RAT
resolver
uniprot_entry
MIRO1_RAT
resolver
amino_acid_sequence
MRAGRVRPLRASDMKKDVRILLVGEPRVGKTSLIMSLVSEEFPEEVPPRAEEITIPADVTPERVPTHIVDYSEAEQSDEQLHQEISQANVICIVYAVNNKHSIDKVTSRWIPLINERTDKDSRLPLILVGNKSDLVEYSSMETILPIMNQYTEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLYCPEEKEMKPACIKALTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVKNVVRKHLSDGVADSGLTLRGFLFLHTLFIQRGRHETTWTVLRRFGYDDDLDLTPEYLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRDCALSPDELKDLFQVFPYIPWGPDVNNTVCTNESGWITYQGFLSQWTLTTYLDVQRCLEYLGYLGYSILTEQESQASAITVTRDKKIDLQKKQTQRNVFRCNVIGVKGCGKTGVLQSLLGRNLMRQKKIRDDHKSYYAINTVYVYGQEKYLLLHDISESEFLTEAEIVCDVVCLVYDVTNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEHSVSPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYPHVTQADLKSSTFWLRASFGATVFAVVGFAMYRALLKQR
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Promotes mitochondrial fission during high calcium conditions. Can hydrolyze GTP, ATP and UTP. {ECO:0000250|UniProtKB:Q8IXI2}.
uniprot
proteins
mass_dalton
72157
uniprot
proteins
mutagenesis
MUTAGEN 105; /note="K->R: Abolishes acetylation."; /evidence="ECO:0000269|PubMed:31068376"; MUTAGEN 525; /note="K->R: Does not affect acetylation."; /evidence="ECO:0000269|PubMed:31068376"; MUTAGEN 629; /note="K->R: Does not affect acetylation."; /evidence="ECO:0000269|PubMed:31068376
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. {ECO:0000250|UniProtKB:Q8IXI2}.; PTM: Acetylation on Lys-105 decreases sensitivity of mitochondrial transport to elevated Ca(2+) levels, increases mitochondrial transport and promotes axon growth (PubMed:31068376). Deacetylated by HDAC6 which blocks mitochondrial transport and mediates axon growth inhibition (PubMed:31068376). {ECO:0000269|PubMed:31068376}.
uniprot
proteins
protein_family
Mitochondrial Rho GTPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
31068376
uniprot
proteins
sequence_length
631
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8IXI2}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8IXI2}. Note=Colocalizes with MGARP and RHOT2 at the mitochondria. {ECO:0000250|UniProtKB:Q8IXI2}.
uniprot
proteins
transmembrane_region
TRANSMEM 606..628; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins