Timm44
entrez
21856
canonical
uniprot
O35857
canonical
ensembl
ENSMUSG00000002949
resolver
ensp
ENSMUSP00000003029
resolver
enst
ENSMUST00000003029
resolver
genesymbol
Timm44
resolver
genesymbol_syn
Mimt44
resolver
genesymbol_syn
Tim44
resolver
uniprot
Q2NLC5
resolver
uniprot_entry
TIM44_MOUSE
resolver
uniprot_sec
Q2NLC5
resolver
amino_acid_sequence
MAAAALRGGWCRCPRRCLGSGIQFLSSHNLPHGSSYQISRPGRELTLTKSYSSGSRKGFLSGLLDNIKQELAKNKEMKESIKKFRDEAKKLEESDALQEARRKYKSIESETVRTSEAIKKKLGELTGTVKESLDEVSKSDLGRKIKEGVEEAARTAKQSAESVSKSGEKLGKTAAFKAISQGVESVKKELDESVLGQTGPYRRPERLRKRTEFAGAKFKESKVFEANEEALGVVLHKDSKWYQQWKDFKDNNVVFNRFFEMKMKYDESDNVLIRASRALTDKVTDLLGGLFSKTEMSEVLTEILRVDPTFDKDHFLHQCETDIIPNILEAMISGELDILKDWCYEATYSQLAHPIQQAKALGFQFHSRILDISNVDLAMGKMMEQGPVLIVTFQAQVVMVIKNSKGEVYDGDPDKVQRMLYVWALCRDQEELNPYAAWRLLDISASSTEQIL
uniprot
proteins
function
FUNCTION: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (PubMed:31618756). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). {ECO:0000250|UniProtKB:Q01852, ECO:0000269|PubMed:31618756}.
uniprot
proteins
mass_dalton
51091
uniprot
proteins
mutagenesis
MUTAGEN 282; /note="K->D: Abolished interaction with SLC25A4/ANT1."; /evidence="ECO:0000269|PubMed:31618756
uniprot
proteins
protein_family
Tim44 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
31618756
uniprot
proteins
pubmed
9419343
uniprot
proteins
sequence_length
452
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:9419343}; Peripheral membrane protein {ECO:0000269|PubMed:9419343}; Matrix side {ECO:0000269|PubMed:9419343}.
uniprot
proteins