CCNY
entrez
219771
canonical
uniprot
Q8ND76
canonical
ensembl
ENSG00000108100
resolver
ensp
ENSP00000265375
resolver
ensp
ENSP00000344275
resolver
ensp
ENSP00000363836
resolver
ensp
ENSP00000363838
resolver
genesymbol
CCNY
resolver
genesymbol_syn
C10orf9
resolver
genesymbol_syn
CBCP1
resolver
genesymbol_syn
CFP1
resolver
hgnc
HGNC:23354
resolver
uniprot
B7Z8E4
resolver
uniprot
B7ZKX9
resolver
uniprot
D3DRY9
resolver
uniprot
Q2M3V4
resolver
uniprot
Q2TU96
resolver
uniprot
Q6NT86
resolver
uniprot
Q7Z4U7
resolver
uniprot
Q8TEX2
resolver
uniprot
Q8TEX3
resolver
uniprot
Q96M99
resolver
uniprot
Q96P45
resolver
uniprot_entry
B7Z8E4_HUMAN
resolver
uniprot_entry
CCNY_HUMAN
resolver
uniprot_sec
B7ZKX9
resolver
uniprot_sec
D3DRY9
resolver
uniprot_sec
Q2M3V4
resolver
uniprot_sec
Q2TU96
resolver
uniprot_sec
Q6NT86
resolver
uniprot_sec
Q7Z4U7
resolver
uniprot_sec
Q8TEX2
resolver
uniprot_sec
Q8TEX3
resolver
uniprot_sec
Q96M99
resolver
uniprot_sec
Q96P45
resolver
amino_acid_sequence
MGNTTSCCVSSSPKLRRNAHSRLESYRPDTDLSREDTGCNLQHISDRENIDDLNMEFNPSDHPRASTIFLSKSQTDVREKRKSLFINHHPPGQIARKYSSCSTIFLDDSTVSQPNLKYTIKCVALAIYYHIKNRDPDGRMLLDIFDENLHPLSKSEVPPDYDKHNPEQKQIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPANWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNELERQFLELLQFNINVPSSVYAKYYFDLRSLAEANNLSFPLEPLSRERAHKLEAISRLCEDKYKDLRRSARKRSASADNLTLPRWSPAIIS
uniprot
proteins
function
FUNCTION: Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}.
uniprot
proteins
mass_dalton
39337
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Induces a diffuse cytoplasmic localization."; /evidence="ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949"; MUTAGEN 3; /note="N->A: No effect on subcellular location."; /evidence="ECO:0000269|PubMed:19524571
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; leading to its degradation. {ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:24794231}.; PTM: Heavily phosphorylated. Phosphorylation at Ser-71 and Ser-73 by CDK14 is enhanced during the G2 and M cell cycle phases, and creates a phosphodegron triggering SCF-dependent ubiquitination. {ECO:0000269|PubMed:24794231}.
uniprot
proteins
protein_family
Cyclin Y subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18060517
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19524571
uniprot
proteins
pubmed
20059949
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22184064
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24794231
uniprot
proteins
pubmed
27821587
uniprot
proteins
sequence_length
341
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}; Lipid-anchor {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}; Cytoplasmic side {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus.
uniprot
proteins