Fbxl19
entrez
233902
canonical
uniprot
Q6PB97
canonical
ensembl
ENSMUSG00000030811
resolver
ensp
ENSMUSP00000033081
resolver
ensp
ENSMUSP00000140021
resolver
ensp
ENSMUSP00000145616
resolver
ensp
ENSMUSP00000178626
resolver
ensp
ENSMUSP00000344081
resolver
genesymbol
Fbxl19
resolver
uniprot
Q7TSH0
resolver
uniprot
Q8BIB4
resolver
uniprot_entry
FXL19_MOUSE
resolver
uniprot_sec
Q7TSH0
resolver
uniprot_sec
Q8BIB4
resolver
amino_acid_sequence
MSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEDEKFSLSLMECTICNEIVHPGCLKMGKAEGVINSEIPNCWECPRCTQEGRTSKDAGEGPGRRRADNGEEGANLGGGWKLTEEPPPPPPLPRRKGPLPAGPTPDDVPGPPKRKEREGGNEPPTPRKKVKGGRERHLKKVGGDACLLRGADPGSPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPIASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAIRPGTGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCVCMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization (PubMed:28453857, PubMed:29809150). Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner. Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration. Also mediates ubiquitination and degradation of IL-33-induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis (PubMed:22660580). Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:28453857, PubMed:29809150). Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation (PubMed:29809150). In addition, plays a critical role in the recruitment of RNF20 to histone H2B leading to H2B mono-ubiquitination (PubMed:28453857). {ECO:0000250|UniProtKB:Q6PCT2, ECO:0000269|PubMed:28453857, ECO:0000269|PubMed:29809150}.
uniprot
proteins
mass_dalton
73788
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="K->A: Strongly inhibits the recognition of non-methylated CpGs."; /evidence="ECO:0000269|PubMed:29809150
uniprot
proteins
post_translational_modification
PTM: Acetylated by CREBBP; leading to ubiquitination and subsequent proteasomal degradation. {ECO:0000250|UniProtKB:Q6P050}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22660580
uniprot
proteins
pubmed
28453857
uniprot
proteins
pubmed
29809150
uniprot
proteins
sequence_length
674
uniprot
proteins