MRI1
entrez
84245
canonical
uniprot
Q9BV20
canonical
ensembl
ENSG00000037757
resolver
ensp
ENSP00000040663
resolver
ensp
ENSP00000314871
resolver
ensp
ENSP00000536753
resolver
ensp
ENSP00000796073
resolver
genesymbol
MRI1
resolver
genesymbol_syn
MRDI
resolver
hgnc
HGNC:28469
resolver
uniprot
Q8NDC9
resolver
uniprot_entry
MTNA_HUMAN
resolver
uniprot_sec
Q8NDC9
resolver
amino_acid_sequence
MTLEAIRYSRGSLQILDQLLLPKQSRYEAVGSVHQAWEAIRAMKVRGAPAIALVGCLSLAVELQAGAGGPGLAALVAFVRDKLSFLVTARPTAVNMARAARDLADVAAREAEREGATEEAVRERVICCTEDMLEKDLRDNRSIGDLGARHLLERVAPSGGKVTVLTHCNTGALATAGYGTALGVIRSLHSLGRLEHAFCTETRPYNQGARLTAFELVYEQIPATLITDSMVAAAMAHRGVSAVVVGADRVVANGDTANKVGTYQLAIVAKHHGIPFYVAAPSSSCDLRLETGKEIIIEERPGQELTDVNGVRIAAPGIGVWNPAFDVTPHDLITGGIITELGVFAPEELRTALTTTISSRDGTLDGPQM
uniprot
proteins
ec_number
5.3.1.23
uniprot
proteins
function
FUNCTION: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. {ECO:0000255|HAMAP-Rule:MF_03119, ECO:0000269|PubMed:19620624}.
uniprot
proteins
mass_dalton
39150
uniprot
proteins
mutagenesis
MUTAGEN 168; /note="C->S: Abolishes enzymatic activity."; /evidence="ECO:0000269|PubMed:19620624"; MUTAGEN 248; /note="D->A: Abolishes enzymatic activity."; /evidence="ECO:0000269|PubMed:19620624
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. {ECO:0000255|HAMAP-Rule:MF_03119}.
uniprot
proteins
protein_family
EIF-2B alpha/beta/delta subunits family
uniprot
proteins
protein_family
MtnA subfamily
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19620624
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
369
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03119, ECO:0000269|PubMed:19620624}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03119, ECO:0000269|PubMed:19620624}. Cell projection {ECO:0000269|PubMed:19620624}. Note=Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.
uniprot
proteins