SSTR2
entrez
6752
canonical
uniprot
P30874
canonical
ensembl
ENSG00000180616
resolver
ensp
ENSP00000350198
resolver
genesymbol
SSTR2
resolver
hgnc
HGNC:11331
resolver
uniprot
A8K3Y0
resolver
uniprot
B2R9P7
resolver
uniprot
Q4VBP0
resolver
uniprot
Q96GE0
resolver
uniprot
Q96TF2
resolver
uniprot
Q9BWH1
resolver
uniprot_entry
SSR2_HUMAN
resolver
uniprot_sec
A8K3Y0
resolver
uniprot_sec
B2R9P7
resolver
uniprot_sec
Q4VBP0
resolver
uniprot_sec
Q96GE0
resolver
uniprot_sec
Q96TF2
resolver
uniprot_sec
Q9BWH1
resolver
amino_acid_sequence
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
uniprot
proteins
function
FUNCTION: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. {ECO:0000269|PubMed:15231824, ECO:0000269|PubMed:18653781, ECO:0000269|PubMed:19434240, ECO:0000269|PubMed:22495673, ECO:0000269|PubMed:22932785}.
uniprot
proteins
mass_dalton
41333
uniprot
proteins
mutagenesis
MUTAGEN 89; /note="D->A: Expression levels reduced by 60%."; /evidence="ECO:0000269|PubMed:22495673"; MUTAGEN 89; /note="D->L: Expression levels reduced by 80%."; /evidence="ECO:0000269|PubMed:22495673"; MUTAGEN 89; /note="D->R: Slightly reduced expression levels. Remains localized in membrane. Abolishes ligand binding and G protein-mediated calcium release."; /evidence="ECO:0000269|PubMed:22495673"; MUTAGEN 139; /note="D->A: Expression levels reduced by 50%. Significantly reduced ligand binding capacity but increased affinity. Reduced G protein-mediated cAMP release but no effect on G protein mediated calcium release."; /evidence="ECO:0000269|PubMed:22495673"; MUTAGEN 139; /note="D->N: Expression levels reduced by 40%. No significant change in ligand binding capacity or affinity. Reduced G protein-mediated cAMP signaling but no effect on G protein-mediated calcium release."; /evidence="ECO:0000269|PubMed:22495673"; MUTAGEN 140; /note="R->A: Slightly reduced expression levels. No significant change in ligand binding capacity or affinity. No significant change in G protein-mediated cAMP or calcium release."; /evidence="ECO:0000269|PubMed:22495673"; MUTAGEN 140; /note="R->E: Almost abolishes expression. Abolishes membrane localization."; /evidence="ECO:0000269|PubMed:22495673"; MUTAGEN 140; /note="R->L: Slightly reduced expression levels. Significantly reduced ligand binding capacity but increased affinity. Reduced G protein-mediated cAMP release but no effect on G protein-mediated calcium release."; /evidence="ECO:0000269|PubMed:22495673
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10551867
uniprot
proteins
pubmed
10619399
uniprot
proteins
pubmed
1346068
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15231824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18653781
uniprot
proteins
pubmed
19434240
uniprot
proteins
pubmed
22495673
uniprot
proteins
pubmed
22932785
uniprot
proteins
pubmed
8386508
uniprot
proteins
sequence_length
369
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
uniprot
proteins
transmembrane_region
TRANSMEM 44..67; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 79..103; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 119..138; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 162..181; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 208..229; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 254..278; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 289..303; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins