Dpysl2
entrez
25416
canonical
uniprot
P47942
canonical
ensembl
ENSRNOG00000009625
resolver
ensembl
ENSRNOG00055006785
resolver
ensembl
ENSRNOG00060011761
resolver
ensembl
ENSRNOG00065017984
resolver
ensp
ENSRNOP00000012996
resolver
ensp
ENSRNOP00000097378
resolver
ensp
ENSRNOP00055008706
resolver
ensp
ENSRNOP00060015658
resolver
ensp
ENSRNOP00065023986
resolver
enst
ENSRNOT00000012996
resolver
enst
ENSRNOT00000111164
resolver
enst
ENSRNOT00055011125
resolver
enst
ENSRNOT00060019934
resolver
enst
ENSRNOT00065030193
resolver
genesymbol
Dpysl2
resolver
uniprot
A0A8I6ANE0
resolver
uniprot_entry
A0A8I6ANE0_RAT
resolver
uniprot_entry
DPYL2_RAT
resolver
amino_acid_sequence
MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLHVDITEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDSQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRSITIANQTNCPLYVTKVMSKSAAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRISVGSDADLVIWDPDSVKTISAKTHNSALEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFSLSGAQIDDNIPRRTTQRIVAPPGGRANITSLG
uniprot
proteins
function
FUNCTION: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
62278
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B. Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Hydantoinase/dihydropyrimidinase family
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
pubmed
10757975
uniprot
proteins
pubmed
16418269
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7472434
uniprot
proteins
pubmed
9375656
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}. Note=Tightly but noncovalently associated with membranes. {ECO:0000269|PubMed:7472434}.
uniprot
proteins