Trpc1
entrez
22063
canonical
uniprot
Q61056
canonical
ensembl
ENSMUSG00000032839
resolver
ensp
ENSMUSP00000057640
resolver
ensp
ENSMUSP00000139672
resolver
ensp
ENSMUSP00000260235
resolver
ensp
ENSMUSP00000260236
resolver
ensp
ENSMUSP00000260241
resolver
enst
ENSMUST00000053785
resolver
enst
ENSMUST00000189137
resolver
genesymbol
Trpc1
resolver
genesymbol_syn
Trp1
resolver
genesymbol_syn
Trrp1
resolver
uniprot
A0A087WP84
resolver
uniprot
B2RPS7
resolver
uniprot
B7ZMP6
resolver
uniprot
F6V872
resolver
uniprot
O35722
resolver
uniprot_entry
A0A087WP84_MOUSE
resolver
uniprot_entry
B2RPS7_MOUSE
resolver
uniprot_entry
B7ZMP6_MOUSE
resolver
uniprot_entry
F6V872_MOUSE
resolver
uniprot_entry
TRPC1_MOUSE
resolver
uniprot_sec
O35722
resolver
activity_regulation
ACTIVITY REGULATION: May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G protein coupled receptors (By similarity). Also activated by intracellular calcium store depletion (By similarity). {ECO:0000250|UniProtKB:P48995}.
uniprot
proteins
amino_acid_sequence
MMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENESLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN
uniprot
proteins
function
FUNCTION: Forms a receptor-activated non-selective calcium permeant cation channel. Forms a heteromeric ion channel with TRPC4 or TRPC5 that has reduced calcium permeability compared to the homomeric TRPC4 or TRPC5 channel (By similarity). Also permeable to monovalent ions including sodium, lithium and cesium ions (By similarity). {ECO:0000250|UniProtKB:P48995}.
uniprot
proteins
mass_dalton
91213
uniprot
proteins
post_translational_modification
PTM: Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells. {ECO:0000250|UniProtKB:P48995}.
uniprot
proteins
protein_family
STrpC subfamily
uniprot
proteins
protein_family
TRPC1 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
20458742
uniprot
proteins
pubmed
32110987
uniprot
proteins
pubmed
8646775
uniprot
proteins
pubmed
9165220
uniprot
proteins
sequence_length
793
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P48995}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48995}.
uniprot
proteins
transmembrane_region
TRANSMEM 387..404; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:P48995"; TRANSMEM 423..439; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:P48995"; TRANSMEM 456..475; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:P48995"; TRANSMEM 497..517; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:P48995"; TRANSMEM 537..558; /note="Helical; Name=S5"; /evidence="ECO:0000250|UniProtKB:P48995"; TRANSMEM 624..644; /note="Helical; Name=S6"; /evidence="ECO:0000250|UniProtKB:P48995
uniprot
proteins