Tmc7
entrez
209760
canonical
uniprot
Q8C428
canonical
ensembl
ENSMUSG00000042246
resolver
ensp
ENSMUSP00000046927
resolver
genesymbol
Tmc7
resolver
uniprot
Q7TN59
resolver
uniprot
Q7TQ66
resolver
uniprot
Q8C4C3
resolver
uniprot_entry
TMC7_MOUSE
resolver
uniprot_sec
Q7TN59
resolver
uniprot_sec
Q7TQ66
resolver
uniprot_sec
Q8C4C3
resolver
amino_acid_sequence
MSEGSAGDPGHGSSRQRAVHPENLSLGSSCFSPPVNFLQELPSYRSVARRRTNILSRDKQSGTLLKPTDSFSCQLDGGITENLNSQSIRKYALNISEKRRLRDIQETQMKYLSEWDQWKRYSSKSWKRFLEKAREMTTHLELWRKDIRSIEGKFGTGIQSYFSFLRFLVVLNLVIFLIIFMLVLLPILLTKYKITNSTFVLIPFKDMDIQCTLYPISSSGLIYFYSYIIDLLSGTGFLEETSLFYGHYTIDGVKFQSFTYDLPLAYLISTIAYLALSLLWIVKRSVEGFKINLIRSEEHFQSYCNKIFAGWDFCITNRSMAELKHSSLRYELRADLEEERIRQKIAERTSEETIRIYTLRLFLNCIVLAVLAACFYAIYLATAFSQEHMKKEIDKMVFGENLLILYLPSIVITLANFITPIIFAKIIHYEDYSPGFEIRLTILRCVFMRLATICVLVFTLGSKITSCGDSTCELCGYNQKLYPCWETQVGQEMYKLMIFDFIIILAVTLFVDFPRKLLVTYCASSKLIQCWGQQEFAIPDNVLGIVYGQTICWIGAFFSPLLPAIATLKFVIIFYVKELSLLYTCRPSPRQFRASNSNFFFLLVLLIGLCLAIIPLTISMARIPSSKACGPFTNFNTTWEVIPQTVSTFPSSLQTLIHAVTSEAFAVPFFMIICLVMFYFIALAGAHKQVVVQLREQLSLESRDKRYLIQKLTEAQREVRSQPASA
uniprot
proteins
function
FUNCTION: Acts as an inhibitory modulator of Piezo2 mechanosensitive channel in dorsal root ganglion (DRG) neurons through physical interactions or interference with the interaction between PIEZO2 and the cytoskeleton. {ECO:0000269|PubMed:38568807}.
uniprot
proteins
mass_dalton
83337
uniprot
proteins
protein_family
TMC family
uniprot
proteins
pubmed
12812529
uniprot
proteins
pubmed
12906855
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
38568807
uniprot
proteins
sequence_length
726
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 218..238; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 262..282; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 361..381; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 403..423; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 493..513; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 554..574; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 599..619; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 664..684; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins