Smpd2
entrez
83537
canonical
uniprot
Q9ET64
canonical
ensembl
ENSRNOG00000000306
resolver
ensembl
ENSRNOG00055000696
resolver
ensembl
ENSRNOG00060007132
resolver
ensembl
ENSRNOG00065008547
resolver
ensp
ENSRNOP00000000336
resolver
ensp
ENSRNOP00055000943
resolver
ensp
ENSRNOP00060008821
resolver
ensp
ENSRNOP00065010073
resolver
enst
ENSRNOT00000000336
resolver
enst
ENSRNOT00055001188
resolver
enst
ENSRNOT00060011719
resolver
enst
ENSRNOT00065013572
resolver
genesymbol
Smpd2
resolver
uniprot
Q5BKB2
resolver
uniprot_entry
NSMA_RAT
resolver
uniprot_sec
Q5BKB2
resolver
amino_acid_sequence
MKHNFSLRLRVFNLNCWDIPYLSKHRADRMKRLGDFLNLESFDLALLEEVWSEQDFQYLKQKLSLTYPDAHYFRSGIIGSGLCVFSRHPIQEIVQHVYTLNGYPYKFYHGDWFCGKAVGLLVLHLSGLVLNAYVTHLHAEYSRQKDIYFAHRVAQAWELAQFIHHTSKKANVVLLCGDLNMHPKDLGCCLLKEWTGLRDAFVETEDFKGSEDGCTMVPKNCYVSQQDLGPFPFGVRIDYVLYKAVSGFHICCKTLKTTTGCDPHNGTPFSDHEALMATLCVKHSPPQEDPCSAHGSAERSALISALREARTELGRGIAQARWWAALFGYVMILGLSLLVLLCVLAAGEEAREVAIMLWTPSVGLVLGAGAVYLFHKQEAKSLCRAQAEIQHVLTRTTETQDLGSEPHPTHCRQQEADRAEEK
uniprot
proteins
ec_number
3.1.4.12
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). {ECO:0000250|UniProtKB:O60906}.
uniprot
proteins
mass_dalton
47645
uniprot
proteins
mutagenesis
MUTAGEN 136; /note="H->A: Complete loss of activity."; /evidence="ECO:0000269|PubMed:10832103"; MUTAGEN 151; /note="H->A: Reduced activity."; /evidence="ECO:0000269|PubMed:10832103"; MUTAGEN 151; /note="H->Y: Complete loss of activity."; /evidence="ECO:0000269|PubMed:10832103"; MUTAGEN 272; /note="H->A: Complete loss of activity."; /evidence="ECO:0000269|PubMed:10832103
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000250|UniProtKB:O60906}.
uniprot
proteins
protein_family
Neutral sphingomyelinase family
uniprot
proteins
pubmed
10832103
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 325..345; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 354..374; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins