Cpeb1
entrez
12877
canonical
uniprot
P70166
canonical
ensembl
ENSMUSG00000025586
resolver
ensp
ENSMUSP00000095936
resolver
ensp
ENSMUSP00000120139
resolver
ensp
ENSMUSP00000137079
resolver
ensp
ENSMUSP00000256403
resolver
ensp
ENSMUSP00000256405
resolver
enst
ENSMUST00000098331
resolver
enst
ENSMUST00000178892
resolver
genesymbol
Cpeb1
resolver
genesymbol_syn
Cpeb
resolver
uniprot
J3QP35
resolver
uniprot
Q059Z2
resolver
uniprot
Q8C5P9
resolver
uniprot_entry
CPEB1_MOUSE
resolver
uniprot_entry
J3QP35_MOUSE
resolver
uniprot_entry
Q059Z2_MOUSE
resolver
uniprot_sec
Q8C5P9
resolver
amino_acid_sequence
MAFSLEEAAGRIKDCWDNQEVPALSTCSNANIFRRINAILDDSLDFSKVCTTPINRGIHDQLPDFQDSEETVTSRMLFPTSAQESPRGLPDANGLCLGLQSLSLTGWDRPWSTQDSDSSAQSSTQSVLSMLQNPLGNVLGKAPLSFLSLDPLGSDLDKFPAPSVRGSRLDTRPILDSRSSSPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLSMTGNGPRDPLKMGVGSRMDQEQAALAAVAPSPTSAPKRWPGASVWPSWDLLGAPKDPFSIEREARLHRQAAAVNEATCTWSGQLPPRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGKDGKHPRCPPKGNMPKGYVYLVFELEKSVRALLQACSHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSNFVWSPSQRLDPSRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLKAVTAAFVEIKTTKFTKKVQIDPYLEDSLCLICSSQPGPFFCRDQVCFKYFCRSCWHWRHSMEGLRHHSPLMRNQKN
uniprot
proteins
function
FUNCTION: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress (By similarity). Required for cell cycle progression, specifically for prophase entry (By similarity). {ECO:0000250|UniProtKB:Q9BZB8, ECO:0000269|PubMed:11526086, ECO:0000269|PubMed:11980711, ECO:0000269|PubMed:12629046}.
uniprot
proteins
mass_dalton
61917
uniprot
proteins
mutagenesis
MUTAGEN 171; /note="T->A: Inhibits CPE-containing cytoplasmic polyadenylation and translation activation."; /evidence="ECO:0000269|PubMed:12815066, ECO:0000269|PubMed:15175389
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine/threonine residues by AURKA within positions 165 and 196 (By similarity). Phosphorylation and dephosphorylation on Thr-171 regulates cytoplasmic polyadenylation and translation of CPE-containing mRNAs. Phosphorylation on Thr-171 by AURKA in embryonic ovaries at 16.5 dpc (mostly pachytene oocytes) activates CPEB1. Not phosphorylated on Thr-171 in embryonic ovaries between 18.5 dpc (diplotene oocytes) and metaphase I. Dephosphorylation on Thr-171 by PP1 in embryonic ovaries at 18.5 dpc (mostly diplotene oocytes) inactivates CPEB1. In maturing oocytes, re-phosphorylation on Thr-171 by AURKA reactivates CPEB1. Phosphorylation on Thr-171 by CAMK2A in depolarized hippocampal neurons activates CPEB1. Dephosphorylation on Thr-171 (indirectly by PP1) in hippocampal neurons inactivates CPEB1. Phosphorylation on Thr-171 may be promoted by APLP1. Phosphorylation increases binding to RNA. {ECO:0000250, ECO:0000269|PubMed:11526086, ECO:0000269|PubMed:11980711, ECO:0000269|PubMed:12815066, ECO:0000269|PubMed:15175389, ECO:0000269|PubMed:15944388, ECO:0000269|PubMed:16314516}.
uniprot
proteins
protein_family
RRM CPEB family
uniprot
proteins
pubmed
11526086
uniprot
proteins
pubmed
11980711
uniprot
proteins
pubmed
12629046
uniprot
proteins
pubmed
12815066
uniprot
proteins
pubmed
12871996
uniprot
proteins
pubmed
15175389
uniprot
proteins
pubmed
15944388
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16314516
uniprot
proteins
pubmed
16705177
uniprot
proteins
pubmed
17927953
uniprot
proteins
pubmed
8962099
uniprot
proteins
pubmed
9856468
uniprot
proteins
sequence_length
561
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Synapse {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Membrane {ECO:0000250}. Postsynaptic density {ECO:0000250}. Note=Localizes in synaptosomes at dendritic synapses of neurons. Strongly enriched in postsynaptic density (PSD) fractions. Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin. Membrane-associated. Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TACC3, AURKA, SYP, etc.) including CPE-containing RNAs. In P-bodies and stress granules (By similarity). Recruited to stress granules (SGs) upon arsenite treatment (By similarity). {ECO:0000250}.
uniprot
proteins