Gabarap
entrez
58974
canonical
uniprot
P60517
canonical
ensembl
ENSRNOG00055031485
resolver
ensembl
ENSRNOG00060031714
resolver
ensembl
ENSRNOG00065027622
resolver
ensp
ENSRNOP00055045087
resolver
ensp
ENSRNOP00060045434
resolver
ensp
ENSRNOP00065039058
resolver
enst
ENSRNOT00055054525
resolver
enst
ENSRNOT00060054946
resolver
enst
ENSRNOT00065047619
resolver
genesymbol
Gabarap
resolver
uniprot
Q9QUI7
resolver
uniprot_entry
GBRAP_RAT
resolver
uniprot_sec
Q9QUI7
resolver
amino_acid_sequence
MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGL
uniprot
proteins
function
FUNCTION: Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (PubMed:11461150). Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (By similarity). Participates in selective ER-phagy through interaction with UBAC2, promoting recruitment of UBAC2-associated ER fragments to autophagosomes (By similarity). In addition to autophagy, also regulates lysosome biogenesis via interaction with FNIP1 (or FNIP2): interaction sequesters the FLCN-FNIP complex and prevents non-canonical mTORC1 signaling cascade activation, leading to activation of transcription factors TFEB and TFE3 (By similarity). Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction (By similarity). Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation (By similarity). Involved in apoptosis (By similarity). {ECO:0000250|UniProtKB:O95166, ECO:0000269|PubMed:11461150}.
uniprot
proteins
mass_dalton
13918
uniprot
proteins
post_translational_modification
PTM: The precursor molecule is cleaved by ATG4 (ATG4A, ATG4B, ATG4C or ATG4D) to expose the glycine at the C-terminus and form the cytosolic form, GABARAP-I. The processed form is then activated by APG7L/ATG7, transferred to ATG3 and conjugated to phosphatidylethanolamine (PE) phospholipid to form the membrane-bound form, GABARAP-II. During non-canonical autophagy, the processed form is conjugated to phosphatidylserine (PS) phospholipid. ATG4 proteins also mediate the delipidation of PE-conjugated forms. In addition, ATG4B and ATG4D mediate delipidation of ATG8 proteins conjugated to PS during non-canonical autophagy. ATG4B constitutes the major protein for proteolytic activation (By similarity). ATG4D is the main enzyme for delipidation activity (By similarity). {ECO:0000250|UniProtKB:O95166, ECO:0000250|UniProtKB:Q9DCD6}.
uniprot
proteins
protein_family
ATG8 family
uniprot
proteins
pubmed
10899939
uniprot
proteins
pubmed
10900017
uniprot
proteins
pubmed
11461150
uniprot
proteins
pubmed
11818336
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25172774
uniprot
proteins
sequence_length
117
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:O95166}. Endomembrane system {ECO:0000269|PubMed:11461150}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10899939}. Golgi apparatus membrane {ECO:0000269|PubMed:11461150}. Cytoplasmic vesicle {ECO:0000269|PubMed:25172774}. Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae (PubMed:11461150). Colocalizes with microtubules (PubMed:10899939). Also localizes to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:Q9DCD6, ECO:0000269|PubMed:10899939, ECO:0000269|PubMed:11461150}.
uniprot
proteins