MSRB1
entrez
51734
canonical
uniprot
Q9NZV6
canonical
ensembl
ENSG00000198736
resolver
ensembl
ENSG00000291928
resolver
ensp
ENSP00000355084
resolver
ensp
ENSP00000517565
resolver
enst
ENST00000361871
resolver
enst
ENST00000709225
resolver
genesymbol
MSRB1
resolver
genesymbol_syn
SEPX1
resolver
hgnc
HGNC:14133
resolver
uniprot
Q96RX6
resolver
uniprot
Q9BTV2
resolver
uniprot
Q9P0B1
resolver
uniprot_entry
MSRB1_HUMAN
resolver
uniprot_sec
Q96RX6
resolver
uniprot_sec
Q9BTV2
resolver
uniprot_sec
Q9P0B1
resolver
amino_acid_sequence
MSFCSFFGGEVFQNHFEPGVYVCAKCGYELFSSRSKYAHSSPWPAFTETIHADSVAKRPEHNRSEALKVSCGKCGNGLGHEFLNDGPKPGQSRFUIFSSSLKFVPKGKETSASQGH
uniprot
proteins
ec_number
1.8.4.12
uniprot
proteins
ec_number
1.8.4.14
uniprot
proteins
function
FUNCTION: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages. {ECO:0000250|UniProtKB:Q9JLC3}.
uniprot
proteins
mass_dalton
12760
uniprot
proteins
post_translational_modification
PTM: Truncated MSRB1/SEPX1 proteins produced by failed UGA/Sec decoding are ubiquitinated by some Cul2-RING E3 ubiquitin-protein ligase complexes (containing either PRAME, PRAMF6, PRAMF9 or FEM1C as substrate-recognition component). {ECO:0000269|PubMed:26138980}.
uniprot
proteins
protein_family
MsrB Met sulfoxide reductase family
uniprot
proteins
pubmed
10608886
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11157797
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
26138980
uniprot
proteins
sequence_length
116
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9JLC3}. Nucleus {ECO:0000250|UniProtKB:Q9JLC3}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9JLC3}.
uniprot
proteins