PRSS1
entrez
5644
canonical
uniprot
P07477
canonical
ensembl
ENSG00000204983
resolver
ensembl
ENSG00000274247
resolver
ensp
ENSP00000308720
resolver
ensp
ENSP00000479217
resolver
enst
ENST00000311737
resolver
enst
ENST00000616256
resolver
genesymbol
PRSS1
resolver
genesymbol_syn
TRP1
resolver
genesymbol_syn
TRY1
resolver
genesymbol_syn
TRYP1
resolver
hgnc
HGNC:9475
resolver
uniprot
A1A509
resolver
uniprot
A6NJ71
resolver
uniprot
B2R5I5
resolver
uniprot
Q5NV57
resolver
uniprot
Q7M4N3
resolver
uniprot
Q7M4N4
resolver
uniprot
Q92955
resolver
uniprot
Q9HAN4
resolver
uniprot
Q9HAN5
resolver
uniprot
Q9HAN6
resolver
uniprot
Q9HAN7
resolver
uniprot_entry
TRY1_HUMAN
resolver
uniprot_sec
A1A509
resolver
uniprot_sec
A6NJ71
resolver
uniprot_sec
B2R5I5
resolver
uniprot_sec
Q5NV57
resolver
uniprot_sec
Q7M4N3
resolver
uniprot_sec
Q7M4N4
resolver
uniprot_sec
Q92955
resolver
uniprot_sec
Q9HAN4
resolver
uniprot_sec
Q9HAN5
resolver
uniprot_sec
Q9HAN6
resolver
uniprot_sec
Q9HAN7
resolver
amino_acid_sequence
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
uniprot
proteins
disease_involvement
DISEASE: Pancreatitis, hereditary (PCTT) [MIM:167800]: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. {ECO:0000269|PubMed:10204851, ECO:0000269|PubMed:10381903, ECO:0000269|PubMed:10930381, ECO:0000269|PubMed:11073545, ECO:0000269|PubMed:11788572, ECO:0000269|PubMed:11866271, ECO:0000269|PubMed:14695529, ECO:0000269|PubMed:15776435, ECO:0000269|PubMed:8841182, ECO:0000269|PubMed:9322498, ECO:0000269|PubMed:9633818}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.21.4
uniprot
proteins
function
FUNCTION: Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates. {ECO:0000269|PubMed:7945238}.
uniprot
proteins
mass_dalton
26558
uniprot
proteins
mutagenesis
MUTAGEN 154; /note="Y->F: Lack of sulfation."; /evidence="ECO:0000269|PubMed:17087724
uniprot
proteins
post_translational_modification
PTM: Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122.; PTM: Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins. {ECO:0000269|PubMed:25010489}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10204851
uniprot
proteins
pubmed
10381903
uniprot
proteins
pubmed
10930381
uniprot
proteins
pubmed
11057674
uniprot
proteins
pubmed
11073545
uniprot
proteins
pubmed
11788572
uniprot
proteins
pubmed
11866271
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14695529
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15776435
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17087724
uniprot
proteins
pubmed
25010489
uniprot
proteins
pubmed
2598466
uniprot
proteins
pubmed
3011602
uniprot
proteins
pubmed
7945238
uniprot
proteins
pubmed
8650574
uniprot
proteins
pubmed
8683601
uniprot
proteins
pubmed
8841182
uniprot
proteins
pubmed
9322498
uniprot
proteins
pubmed
9633818
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space.
uniprot
proteins