CCL3
entrez
6348
canonical
uniprot
P10147
canonical
ensembl
ENSG00000274221
resolver
ensembl
ENSG00000277632
resolver
ensembl
ENSG00000278567
resolver
ensp
ENSP00000477908
resolver
ensp
ENSP00000480753
resolver
ensp
ENSP00000483712
resolver
enst
ENST00000613396
resolver
enst
ENST00000613922
resolver
enst
ENST00000616221
resolver
genesymbol
CCL3
resolver
genesymbol_syn
G0S19-1
resolver
genesymbol_syn
MIP1A
resolver
genesymbol_syn
SCYA3
resolver
hgnc
HGNC:10627
resolver
uniprot
A0N0R1
resolver
uniprot_entry
A0N0R1_HUMAN
resolver
uniprot_entry
CCL3_HUMAN
resolver
amino_acid_sequence
MQVSTAALAVLLCTMALCNQFSASLAADTPTACCFSYTSRQIPQNFIADYFETSSQCSKPGVIFLTKRSRQVCADPSEEWVQKYVSDLELSA
uniprot
proteins
function
FUNCTION: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). {ECO:0000269|PubMed:15905581, ECO:0000269|PubMed:8525373}.
uniprot
proteins
mass_dalton
10085
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="R->A: Slightly reduces heparin binding."; /evidence="ECO:0000269|PubMed:9092555"; MUTAGEN 49; /note="D->A: Reduces self-association; in BB-10010: Improved pharmaceutical properties."; /evidence="ECO:0000269|PubMed:10347159, ECO:0000269|PubMed:8541527"; MUTAGEN 68; /note="R->A: Strongly reduces heparin binding."; /evidence="ECO:0000269|PubMed:9092555"; MUTAGEN 70; /note="R->A: Reduces heparin binding."; /evidence="ECO:0000269|PubMed:9092555"; MUTAGEN 89; /note="E->A: Reduces self-association."; /evidence="ECO:0000269|PubMed:10347159
uniprot
proteins
post_translational_modification
PTM: N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
10347159
uniprot
proteins
pubmed
12070155
uniprot
proteins
pubmed
12401480
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15905581
uniprot
proteins
pubmed
1694014
uniprot
proteins
pubmed
20041127
uniprot
proteins
pubmed
2271120
uniprot
proteins
pubmed
2521882
uniprot
proteins
pubmed
3086300
uniprot
proteins
pubmed
7537510
uniprot
proteins
pubmed
8525373
uniprot
proteins
pubmed
8541527
uniprot
proteins
pubmed
9092555
uniprot
proteins
sequence_length
92
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins