ERLEC1
entrez
27248
canonical
uniprot
Q96DZ1
canonical
ensembl
ENSG00000068912
resolver
ensp
ENSP00000185150
resolver
ensp
ENSP00000367485
resolver
ensp
ENSP00000385629
resolver
genesymbol
ERLEC1
resolver
genesymbol
HEL117
resolver
genesymbol_syn
C2orf30
resolver
genesymbol_syn
XTP3TPB
resolver
hgnc
HGNC:25222
resolver
uniprot
B2RDB4
resolver
uniprot
B5MC72
resolver
uniprot
O95901
resolver
uniprot
Q6UWN7
resolver
uniprot
Q9NUY7
resolver
uniprot
Q9UQL4
resolver
uniprot
V9HWD3
resolver
uniprot_entry
ERLEC_HUMAN
resolver
uniprot_entry
V9HWD3_HUMAN
resolver
uniprot_sec
B2RDB4
resolver
uniprot_sec
B5MC72
resolver
uniprot_sec
O95901
resolver
uniprot_sec
Q6UWN7
resolver
uniprot_sec
Q9NUY7
resolver
uniprot_sec
Q9UQL4
resolver
amino_acid_sequence
MEEGGGGVRSLVPGGPVLLVLCGLLEASGGGRALPQLSDDIPFRVNWPGTEFSLPTTGVLYKEDNYVIMTTAHKEKYKCILPLVTSGDEEEEKDYKGPNPRELLEPLFKQSSCSYRIESYWTYEVCHGKHIRQYHEEKETGQKINIHEYYLGNMLAKNLLFEKEREAEEKEKSNEIPTKNIEGQMTPYYPVGMGNGTPCSLKQNRPRSSTVMYICHPESKHEILSVAEVTTCEYEVVILTPLLCSHPKYRFRASPVNDIFCQSLPGSPFKPLTLRQLEQQEEILRVPFRRNKEEDLQSTKEERFPAIHKSIAIGSQPVLTVGTTHISKLTDDQLIKEFLSGSYCFRGGVGWWKYEFCYGKHVHQYHEDKDSGKTSVVVGTWNQEEHIEWAKKNTARAYHLQDDGTQTVRMVSHFYGNGDICDITDKPRQVTVKLKCKESDSPHAVTVYMLEPHSCQYILGVESPVICKILDTADENGLLSLPN
uniprot
proteins
function
FUNCTION: Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins. {ECO:0000269|PubMed:16531414, ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:18502753}.
uniprot
proteins
mass_dalton
54858
uniprot
proteins
mutagenesis
MUTAGEN 207; /note="R->A: Abolishes interaction with SEL1L."; /evidence="ECO:0000269|PubMed:18264092"; MUTAGEN 379; /note="G->S: Abolishes binding to KREMEN2."; /evidence="ECO:0000269|PubMed:16531414"; MUTAGEN 428; /note="R->A: Abolishes interaction with SEL1L."; /evidence="ECO:0000269|PubMed:18264092
uniprot
proteins
post_translational_modification
PTM: Isoform 1 and isoform 2 are N-glycosylated. {ECO:0000269|PubMed:18502753}.
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16531414
uniprot
proteins
pubmed
18264092
uniprot
proteins
pubmed
18502753
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:16531414, ECO:0000269|PubMed:18502753}.
uniprot
proteins