MORN3
entrez
283385
canonical
uniprot
Q6PF18
canonical
ensembl
ENSG00000139714
resolver
ensp
ENSP00000347486
resolver
ensp
ENSP00000549241
resolver
genesymbol
MORN3
resolver
hgnc
HGNC:29807
resolver
uniprot
Q86YQ9
resolver
uniprot_entry
MORN3_HUMAN
resolver
uniprot_sec
Q86YQ9
resolver
amino_acid_sequence
MPVSKCPKKSESLWKGWDRKAQRNGLRSQVYAVNGDYYVGEWKDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFWVDNMAKCGTMIDFGRDEAPEPTQFPIPEVKILDPDGVLAEALAMFRKTEEGD
uniprot
proteins
function
FUNCTION: Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors (PubMed:29681526). May play a role in the regulation of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q8C5T4, ECO:0000269|PubMed:29681526}.
uniprot
proteins
mass_dalton
27585
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
29681526
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8C5T4}. Note=Localized in the acrosome in germ cells throughout spermiogenesis, it is also present in the manchette of elongating spermatids. {ECO:0000250|UniProtKB:Q8C5T4}.
uniprot
proteins