Fcer1a
entrez
25047
canonical
uniprot
P12371
canonical
ensembl
ENSRNOG00000009177
resolver
ensembl
ENSRNOG00055022890
resolver
ensembl
ENSRNOG00060026208
resolver
ensembl
ENSRNOG00065024682
resolver
ensp
ENSRNOP00000069343
resolver
ensp
ENSRNOP00000092868
resolver
enst
ENSRNOT00000083561
resolver
genesymbol
Fcer1a
resolver
genesymbol_syn
Fce1a
resolver
uniprot
A0A0G2JV43
resolver
uniprot
P12840
resolver
uniprot_entry
A0A0G2JV43_RAT
resolver
uniprot_entry
FCERA_RAT
resolver
uniprot_sec
P12840
resolver
amino_acid_sequence
MDTGGSARLCLALVLISLGVMLTATQKSVVSLDPPWIRILTGDKVTLICNGNNSSQMNSTKWIHNDSISNVKSSHWVIVSATIQDSGKYICQKQGFYKSKPVYLNVMQEWLLLQSSADVVLDNGSFDIRCRSWKKWKVHKVIYYKDDIAFKYSYDSNNISIRKATFNDSGSYHCTGYLNKVECKSDKFSIAVVKDYTIEYRWLQLIFPSLAVILFAVDTGLWFSTHKQFESILKIQKTGKGKKKG
uniprot
proteins
function
FUNCTION: High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions. {ECO:0000250|UniProtKB:P12319}.
uniprot
proteins
mass_dalton
27793
uniprot
proteins
pubmed
17728245
uniprot
proteins
pubmed
19103603
uniprot
proteins
pubmed
2522441
uniprot
proteins
pubmed
2959318
uniprot
proteins
pubmed
2964640
uniprot
proteins
pubmed
2969594
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P12319}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 205..223; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins