MTLN
entrez
205251
canonical
uniprot
Q8NCU8
canonical
ensembl
ENSG00000175701
resolver
ensp
ENSP00000485064
resolver
genesymbol
MTLN
resolver
genesymbol_syn
LEMP
resolver
genesymbol_syn
LINC00116
resolver
genesymbol_syn
MOXI
resolver
genesymbol_syn
MPM
resolver
genesymbol_syn
NCRNA00116
resolver
genesymbol_syn
SMIM37
resolver
hgnc
HGNC:27339
resolver
uniprot_entry
MTLN_HUMAN
resolver
amino_acid_sequence
MADVSERTLQLSVLVAFASGVLLGWQANRLRRRYLDWRKRRLQDKLAATQKKLDLA
uniprot
proteins
function
FUNCTION: Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential while decreasing mitochondrial reactive oxygen species (PubMed:29949756). Increases mitochondrial respiration rate (PubMed:29949756). Increased mitochondrial respiratory activity promotes myogenic differentiation which facilitates muscle growth and regeneration (By similarity). Increases mitochondrial calcium retention capacity (PubMed:29949756). Plays a role in maintenance of cellular lipid composition through its interaction with cytochrome b5 reductase CYB5R3 which is required for mitochondrial respiratory complex I activity (By similarity). Interacts with the mitochondrial trifunctional enzyme complex (MTE) and enhances fatty acid beta-oxidation (PubMed:32243843). Not required for MTE formation or stability (By similarity). Modulates triglyceride clearance in adipocytes through its role in regulating fatty acid beta-oxidation and lipolysis (PubMed:32243843). {ECO:0000250|UniProtKB:Q8BT35, ECO:0000269|PubMed:29949756, ECO:0000269|PubMed:32243843}.
uniprot
proteins
mass_dalton
6527
uniprot
proteins
protein_family
Mitoregulin family
uniprot
proteins
pubmed
23305238
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29949756
uniprot
proteins
pubmed
32243843
uniprot
proteins
sequence_length
56
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8BT35}; Single-pass membrane protein {ECO:0000305}. Note=Preferentially binds to cardiolipin relative to other common cell membrane lipids. {ECO:0000250|UniProtKB:Q8BT35}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..27; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins