Ccr6
entrez
12458
canonical
uniprot
O54689
canonical
ensembl
ENSMUSG00000040899
resolver
ensp
ENSMUSP00000095029
resolver
ensp
ENSMUSP00000128529
resolver
ensp
ENSMUSP00000128559
resolver
ensp
ENSMUSP00000131153
resolver
ensp
ENSMUSP00000135945
resolver
ensp
ENSMUSP00000137249
resolver
ensp
ENSMUSP00000156324
resolver
ensp
ENSMUSP00000350849
resolver
enst
ENSMUST00000097418
resolver
enst
ENSMUST00000164411
resolver
enst
ENSMUST00000166348
resolver
enst
ENSMUST00000167956
resolver
enst
ENSMUST00000177568
resolver
enst
ENSMUST00000180103
resolver
enst
ENSMUST00000231545
resolver
genesymbol
Ccr6
resolver
genesymbol_syn
Cmkbr6
resolver
uniprot
Q542B6
resolver
uniprot_entry
CCR6_MOUSE
resolver
uniprot_entry
Q542B6_MOUSE
resolver
amino_acid_sequence
MNSTESYFGTDDYDNTEYYSIPPDHGPCSLEEVRNFTKVFVPIAYSLICVFGLLGNIMVVMTFAFYKKARSMTDVYLLNMAITDILFVLTLPFWAVTHATNTWVFSDALCKLMKGTYAVNFNCGMLLLACISMDRYIAIVQATKSFRVRSRTLTHSKVICVAVWFISIIISSPTFIFNKKYELQDRDVCEPRYRSVSEPITWKLLGMGLELFFGFFTPLLFMVFCYLFIIKTLVQAQNSKRHRAIRVVIAVVLVFLACQIPHNMVLLVTAVNTGKVGRSCSTEKVLAYTRNVAEVLAFLHCCLNPVLYAFIGQKFRNYFMKIMKDVWCMRRKNKMPGFLCARVYSESYISRQTSETVENDNASSFTM
uniprot
proteins
function
FUNCTION: Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25122636). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (By similarity). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation (PubMed:19050256). Required for the normal migration of Th17 cells in Peyers patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine (PubMed:19129757). Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors (PubMed:24638065). Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches (PubMed:27174992). Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (PubMed:25505290). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988). {ECO:0000250|UniProtKB:P51684, ECO:0000269|PubMed:19050256, ECO:0000269|PubMed:19129757, ECO:0000269|PubMed:20068036, ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:24638065, ECO:0000269|PubMed:25122636, ECO:0000269|PubMed:25505290, ECO:0000269|PubMed:27174992, ECO:0000303|PubMed:21376174}.
uniprot
proteins
mass_dalton
42103
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
19050256
uniprot
proteins
pubmed
19129757
uniprot
proteins
pubmed
20068036
uniprot
proteins
pubmed
21376174
uniprot
proteins
pubmed
23765988
uniprot
proteins
pubmed
24638065
uniprot
proteins
pubmed
25122636
uniprot
proteins
pubmed
25505290
uniprot
proteins
pubmed
27174992
uniprot
proteins
pubmed
9862452
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23765988}; Multi-pass membrane protein {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:P51684}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..66; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 76..96; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 112..133; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 152..172; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 204..230; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 247..271; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 296..313; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins