Kiss1r
entrez
78976
canonical
uniprot
Q924U1
canonical
ensembl
ENSRNOG00000011954
resolver
ensp
ENSRNOP00000016395
resolver
enst
ENSRNOT00000016396
resolver
genesymbol
Kiss1r
resolver
genesymbol_syn
Gpr54
resolver
uniprot
A0A0G2JSL6
resolver
uniprot
A0A1W2Q6L7
resolver
uniprot
Q9Z0T7
resolver
uniprot_entry
A0A0G2JSL6_RAT
resolver
uniprot_entry
KISSR_RAT
resolver
uniprot_sec
A0A1W2Q6L7
resolver
uniprot_sec
Q9Z0T7
resolver
amino_acid_sequence
MAAEATLGPNVSWWAPSNASGCPGCGVNASDGPGSAPRPLDAWLVPLFFAALMLLGLVGNSLVIFVICRHKHMQTVTNFYIANLAATDVTFLLCCVPFTALLYPLPTWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALTVSLSIWVGSAAVSAPVLALHRLSPGPHTYCSEAFPSRALERAFALYNLLALYLLPLLATCACYGAMLRHLGRAAVRPAPTDGALQGQLLAQRAGAVRTKVSRLVAAVVLLFAACWGPIQLFLVLQALGPSGAWHPRSYAAYALKIWAHCMSYSNSALNPLLYAFLGSHFRQAFCRVCPCGPQRQRRPHASAHSDRAAPHSVPHSRAAHPVRVRTPEPGNPVRRSPSVQDEHTAPL
uniprot
proteins
function
FUNCTION: Receptor for kisspeptins (kisspeptin-10, kisspeptin-13, kisspeptin-14 and metastin/kisspeptin-54) (PubMed:11457843). The hypothalamic KISS1/KISS1R signaling system plays a central role in the regulation of the hypothalamic-pituitary-gonadal reproductive axis by modulating the secretion of gonadotropin-releasing hormone (GnRH) from GnRH neurons (PubMed:15219839, PubMed:15242985, PubMed:15375028, PubMed:15486019, PubMed:15500545, PubMed:15637288, PubMed:15665556). In these neurons, kisspeptin binding to its receptor activates G(q)-dependent signaling, leading to phospholipase C (PLC) activation, and hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2). The subsequent rise in intracellular calcium levels results in the inhibition of inward rectifier potassium channels and activation of TRPC-like cation channels, leading to GnRH neurons depolarization and stimulation (By similarity). In addition to this pathway, kisspeptin also triggers G(q)-independent signaling via beta-arrestin, leading to MAPK cascade activation and ERK1/ERK2 phosphorylation (By similarity). In bone tissue, activation of KISS1R by kisspeptin-10 recruits phosphatase DUSP18 and SRC to the KISS1R C-terminus through a G(q)-dependent signaling pathway. This leads to DUSP18-mediated dephosphorylation of SRC, down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (By similarity). KISS1R is also involved in the regulation of other processes, including cell proliferation and cell migration (PubMed:11457843). {ECO:0000250|UniProtKB:Q91V45, ECO:0000269|PubMed:11457843, ECO:0000269|PubMed:15219839, ECO:0000269|PubMed:15242985, ECO:0000269|PubMed:15375028, ECO:0000269|PubMed:15486019, ECO:0000269|PubMed:15500545, ECO:0000269|PubMed:15637288, ECO:0000269|PubMed:15665556}.
uniprot
proteins
mass_dalton
42889
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10100623
uniprot
proteins
pubmed
11385580
uniprot
proteins
pubmed
11457843
uniprot
proteins
pubmed
15157736
uniprot
proteins
pubmed
15219839
uniprot
proteins
pubmed
15242985
uniprot
proteins
pubmed
15375028
uniprot
proteins
pubmed
15486019
uniprot
proteins
pubmed
15500545
uniprot
proteins
pubmed
15593369
uniprot
proteins
pubmed
15637288
uniprot
proteins
pubmed
15665556
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q969F8}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..67; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 91..111; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 121..138; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 306..326; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins