CALCOCO2
entrez
10241
canonical
uniprot
Q13137
canonical
ensembl
ENSG00000136436
resolver
ensp
ENSP00000258947
resolver
ensp
ENSP00000398523
resolver
ensp
ENSP00000406974
resolver
ensp
ENSP00000423437
resolver
ensp
ENSP00000424352
resolver
genesymbol
CALCOCO2
resolver
genesymbol_syn
NDP52
resolver
hgnc
HGNC:29912
resolver
uniprot
B2RBT0
resolver
uniprot
B4DDC4
resolver
uniprot
B4DDT4
resolver
uniprot
B4DP36
resolver
uniprot
B4E0C0
resolver
uniprot
E7ENK0
resolver
uniprot
E7ETP5
resolver
uniprot
E9PBE5
resolver
uniprot
Q53FQ5
resolver
uniprot
Q53HB5
resolver
uniprot
Q6IBN9
resolver
uniprot
Q9BTF7
resolver
uniprot_entry
CACO2_HUMAN
resolver
uniprot_sec
B2RBT0
resolver
uniprot_sec
B4DDC4
resolver
uniprot_sec
B4DDT4
resolver
uniprot_sec
B4DP36
resolver
uniprot_sec
B4E0C0
resolver
uniprot_sec
E7ENK0
resolver
uniprot_sec
E7ETP5
resolver
uniprot_sec
E9PBE5
resolver
uniprot_sec
Q53FQ5
resolver
uniprot_sec
Q53HB5
resolver
uniprot_sec
Q6IBN9
resolver
uniprot_sec
Q9BTF7
resolver
amino_acid_sequence
MEETIKDPPTSAVLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPIDLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQVPTSDEGGARQNPGLAYGNPYSGIQESSSPSPLSIKKCPICKADDICDHTLEQQQMQPLCFNCPICDKIFPATEKQIFEDHVFCHSL
uniprot
proteins
function
FUNCTION: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). {ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:22246324, ECO:0000269|PubMed:23022382, ECO:0000269|PubMed:23386746, ECO:0000269|PubMed:25771791}.
uniprot
proteins
mass_dalton
52254
uniprot
proteins
mutagenesis
MUTAGEN 136; /note="V->S: Abrogates the interaction with MAP1LC3C."; /evidence="ECO:0000269|PubMed:23022382"; MUTAGEN 203..206; /note="DYWE->AAAA: Abrogates interaction with MAPLC3A, MAPLC3B and GABARAPL2."; /evidence="ECO:0000269|PubMed:25771791"; MUTAGEN 374; /note="L->A: Severely reduces affinity for LGALS8."; /evidence="ECO:0000269|PubMed:23386746, ECO:0000269|PubMed:23511477"; MUTAGEN 376; /note="Y->A: Severely reduces affinity for LGALS8."; /evidence="ECO:0000269|PubMed:23386746"; MUTAGEN 378; /note="N->A: Prevents interaction with LGALS8."; /evidence="ECO:0000269|PubMed:23386746"; MUTAGEN 380; /note="Y->A,F: Severely reduced affinity for LGALS8."; /evidence="ECO:0000269|PubMed:23386746, ECO:0000269|PubMed:23511477"; MUTAGEN 400; /note="C->A: Does not affect interaction with MYO6."; /evidence="ECO:0000269|PubMed:17635994"; MUTAGEN 425; /note="C->A: Fails interact with MYO6 and to promote maturation of autophagosomes."; /evidence="ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:25771791
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Cleaved by S.pyogenes SpeB protease; leading to its degradation (PubMed:24331465). Degradation by SpeB prevents autophagy, promoting to S.pyogenes intracellular replication (PubMed:24331465). {ECO:0000269|PubMed:24331465}.
uniprot
proteins
protein_family
CALCOCO family
uniprot
proteins
pubmed
12869526
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17635994
uniprot
proteins
pubmed
22246324
uniprot
proteins
pubmed
23022382
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23386746
uniprot
proteins
pubmed
23511477
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24331465
uniprot
proteins
pubmed
25771791
uniprot
proteins
pubmed
30459273
uniprot
proteins
pubmed
30909570
uniprot
proteins
pubmed
31371777
uniprot
proteins
pubmed
7540613
uniprot
proteins
pubmed
9230084
uniprot
proteins
sequence_length
446
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12869526, ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:9230084}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17635994}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:25771791}; Peripheral membrane protein {ECO:0000305}. Note=According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus. {ECO:0000269|PubMed:12869526, ECO:0000269|PubMed:7540613, ECO:0000269|PubMed:9230084}.
uniprot
proteins