Slc29a3
entrez
353307
canonical
uniprot
Q80WK7
canonical
ensembl
ENSRNOG00000000568
resolver
ensembl
ENSRNOG00055009182
resolver
ensembl
ENSRNOG00060002821
resolver
ensembl
ENSRNOG00065023841
resolver
ensp
ENSRNOP00000082643
resolver
ensp
ENSRNOP00055012459
resolver
ensp
ENSRNOP00060003239
resolver
ensp
ENSRNOP00065033384
resolver
enst
ENSRNOT00000113968
resolver
enst
ENSRNOT00055015544
resolver
enst
ENSRNOT00060004545
resolver
enst
ENSRNOT00065040902
resolver
genesymbol
Slc29a3
resolver
genesymbol_syn
Ent3
resolver
uniprot
Q6AZ86
resolver
uniprot_entry
S29A3_RAT
resolver
uniprot_sec
Q6AZ86
resolver
amino_acid_sequence
MAFASEDIAYHSSNAVYRVPSNRHEADQEALLGKPLDYPAPGLQRPEDRFNGAYIIFFCLGIGGLLPWNFFVTAKEYWAFKLRNCSSPASGKDPEDADILNYFESYLAVASTVPSLLFLVANFLLVNRIRVHVRVLASLSVSLAIFVVMAVLVRVDTSSWTRGFFSIAMACMAIISSSSTIFNSSVYGLTGSFPMRNAQALISGGAMGGTVSAVASLVDLAASSDVRDSALAFFLTAAVFLGLCVGLYLLLPQLEYARYYMRPVVPIHVFSSEDSPPRDAPSTSSVAPASRAVHTPPLGPILKKTAGLGFCAVFLYFITALIFPAISTNIQPMHKGTGSPWTSKFYVPLTVFLLFNFADLCGRQVTAWIQVPGPRSKLLPILAVSRVCLVPLFLLCNYQPRSHLTLVLFQSDIYPILFTCLLGLSNGYLSTLVLMYGPKIVPRELAEATSVVMLFYMSLGLMLGSACAALLEHFI
uniprot
proteins
function
FUNCTION: Uniporter that mediates the facilitative transport of nucleoside across lysosomal and mitochondrial membranes. Functions as a non-electrogenic Na(+)-independent transporter. Transport activity is pH-dependent and enhanced under acidic conditions, consistent with localization to acidic intracellular compartments. Protons are not cotransported but likely modulate transport by altering the ionization state of the transporter which dictates its conformation, thereby regulating substrate permeability. May direct the nucleoside transport from lysosomes to cytosol or cytosol to mitochondria to facilitate nucleic acid salvage pathways. Transports nucleosides (adenosine, guanosine, uridine, thymidine, cytidine and inosine), deoxynucleosides (deoxyadenosine, deoxycytidine), purine nucleobases (adenine, guanine) and pyrimidine nucleobases (uracil). Also capable of transporting monoamine neurotransmitters dopamine, serotonin, noradrenaline and tyramine, as well as ATP (By similarity). Mediates nucleoside export from lysosomes in macrophages, thereby regulating macrophage function and number (By similarity). Also functions as a lysosomal urate exporter, contributing to intracellular urate disposal. Regulates inflammasome activation via dual roles in urate and adenosine transport (By similarity). {ECO:0000250|UniProtKB:Q99P65, ECO:0000250|UniProtKB:Q9BZD2}.
uniprot
proteins
mass_dalton
51677
uniprot
proteins
protein_family
SLC29A/ENT transporter (TC 2.A.57) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15701636
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
475
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9BZD2}; Multi-pass membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000250|UniProtKB:Q9BZD2}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q9BZD2}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q9BZD2}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 106..126; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 133..153; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 200..220; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 231..251; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 306..326; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 341..361; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 378..398; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 415..437; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 451..471; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins