IL6
entrez
3569
canonical
uniprot
P05231
canonical
ensembl
ENSG00000136244
resolver
ensp
ENSP00000258743
resolver
ensp
ENSP00000384928
resolver
ensp
ENSP00000385043
resolver
ensp
ENSP00000385675
resolver
enst
ENST00000258743
resolver
enst
ENST00000401630
resolver
enst
ENST00000404625
resolver
enst
ENST00000407492
resolver
genesymbol
IL6
resolver
genesymbol_syn
IFNB2
resolver
hgnc
HGNC:6018
resolver
uniprot
B4DNQ5
resolver
uniprot
B4DVM1
resolver
uniprot
B5MC21
resolver
uniprot
B5MCZ3
resolver
uniprot
Q75MH2
resolver
uniprot
Q9UCU2
resolver
uniprot
Q9UCU3
resolver
uniprot
Q9UCU4
resolver
uniprot_entry
B4DNQ5_HUMAN
resolver
uniprot_entry
B4DVM1_HUMAN
resolver
uniprot_entry
B5MC21_HUMAN
resolver
uniprot_entry
B5MCZ3_HUMAN
resolver
uniprot_entry
IL6_HUMAN
resolver
uniprot_entry
Q75MH2_HUMAN
resolver
uniprot_sec
Q9UCU2
resolver
uniprot_sec
Q9UCU3
resolver
uniprot_sec
Q9UCU4
resolver
amino_acid_sequence
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
uniprot
proteins
disease_involvement
DISEASE: Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. {ECO:0000269|PubMed:9769329}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. {ECO:0000269|PubMed:11001912}.
uniprot
proteins
function
FUNCTION: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable). {ECO:0000305|PubMed:30995492}.; FUNCTION: IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (Probable). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity). {ECO:0000250|UniProtKB:P08505, ECO:0000305|PubMed:30995492}.; FUNCTION: Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability (PubMed:12794819, PubMed:17075861). Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF (PubMed:12794819). Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (PubMed:20823453). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis (By similarity). Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (Probable). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (PubMed:15124018). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity). {ECO:0000250|UniProtKB:P08505, ECO:0000269|PubMed:12794819, ECO:0000269|PubMed:15124018, ECO:0000269|PubMed:17075861, ECO:0000269|PubMed:20823453, ECO:0000305|PubMed:30995492}.
uniprot
proteins
mass_dalton
23718
uniprot
proteins
mutagenesis
MUTAGEN 173; /note="A->V: Almost no loss of activity."; /evidence="ECO:0000269|PubMed:2037043"; MUTAGEN 185; /note="W->R: No loss of activity."; /evidence="ECO:0000269|PubMed:2037043"; MUTAGEN 204; /note="S->P: 87% loss of activity."; /evidence="ECO:0000269|PubMed:2037043"; MUTAGEN 210; /note="R->K,E,Q,T,A,P: Loss of activity."; /evidence="ECO:0000269|PubMed:2037043"; MUTAGEN 212; /note="M->T,N,S,R: Loss of activity."; /evidence="ECO:0000269|PubMed:2037043
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated. {ECO:0000269|PubMed:1883960}.
uniprot
proteins
protein_family
IL-6 superfamily
uniprot
proteins
pubmed
11001912
uniprot
proteins
pubmed
11080265
uniprot
proteins
pubmed
11355017
uniprot
proteins
pubmed
12768442
uniprot
proteins
pubmed
12794819
uniprot
proteins
pubmed
12829785
uniprot
proteins
pubmed
1291290
uniprot
proteins
pubmed
15124018
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17075861
uniprot
proteins
pubmed
1883960
uniprot
proteins
pubmed
2037043
uniprot
proteins
pubmed
20823453
uniprot
proteins
pubmed
22037645
uniprot
proteins
pubmed
2472117
uniprot
proteins
pubmed
25731159
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
2610854
uniprot
proteins
pubmed
2789513
uniprot
proteins
pubmed
28265003
uniprot
proteins
pubmed
3023045
uniprot
proteins
pubmed
30995492
uniprot
proteins
pubmed
3266463
uniprot
proteins
pubmed
3279116
uniprot
proteins
pubmed
3320204
uniprot
proteins
pubmed
34831181
uniprot
proteins
pubmed
3491322
uniprot
proteins
pubmed
3500852
uniprot
proteins
pubmed
3538015
uniprot
proteins
pubmed
3758081
uniprot
proteins
pubmed
7851440
uniprot
proteins
pubmed
8555185
uniprot
proteins
pubmed
9118960
uniprot
proteins
pubmed
9159484
uniprot
proteins
pubmed
9769329
uniprot
proteins
sequence_length
212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11080265}.
uniprot
proteins