Irf2bpl
entrez
238330
canonical
uniprot
Q8K3X4
canonical
ensembl
ENSMUSG00000034168
resolver
ensp
ENSMUSP00000041070
resolver
enst
ENSMUST00000038422
resolver
genesymbol
Irf2bpl
resolver
genesymbol_syn
Eap1
resolver
genesymbol_syn
Kiaa1865
resolver
uniprot
Q3TBU9
resolver
uniprot
Q3U483
resolver
uniprot
Q3USE5
resolver
uniprot
Q69Z84
resolver
uniprot
Q8BUS1
resolver
uniprot
Q8C011
resolver
uniprot_entry
I2BPL_MOUSE
resolver
uniprot_sec
Q3TBU9
resolver
uniprot_sec
Q3U483
resolver
uniprot_sec
Q3USE5
resolver
uniprot_sec
Q69Z84
resolver
uniprot_sec
Q8BUS1
resolver
uniprot_sec
Q8C011
resolver
amino_acid_sequence
MSAAQVSSSRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLKRAHGCFQDGRSPGPPPPVGVKTVALSAKEAAAAAAAAQQQQQQQQQQQQQLNHVDGSTKPAVLAAPSGLERYGLSAAAAAAAAAAAVEQRSRFEYPPPPVSLGSSSHAARLPNGLGGPNGFPKPAPEEGPPELNRQSPNSSSAATSVASRRGTHSGLVTGLPNPGGGGGPQLTVPPNLLPQTLLNGPASAAVLPPPHGLGGSRGPPTPAPPGAPGGPACLGGPPGVSATVSSAPSSTSSTVAEVGVGAAGKRPGSVSSTDQERELKEKQRNAEALAELSESLRNRAEEWANKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKPGMDYELKLFIEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEKKHGSGDWRLLGDLLPEAVRFFKEGVPGADMLPQPYLDASCPMLPTALVSLSRAPSAPPGTGALPPAAPTGRGAASSLRKRKASPEPPDSAESALKLGEEQQRQQWMANQSEALKLTMSAGGFAAPGHSAGGPPPPPPPLGPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARRNSSSPVSPASVPGQRRLASRNGDLNLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCCTICHERLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERDP
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins. Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway. Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000250|UniProtKB:Q9H1B7}.
uniprot
proteins
mass_dalton
80565
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9H1B7}.
uniprot
proteins
protein_family
IRF2BP family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
775
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q2MJS2, ECO:0000250|UniProtKB:Q5EIC4}.
uniprot
proteins