DIXDC1
entrez
85458
canonical
uniprot
Q155Q3
canonical
ensembl
ENSG00000150764
resolver
ensp
ENSP00000394352
resolver
ensp
ENSP00000434130
resolver
ensp
ENSP00000480808
resolver
genesymbol
DIXDC1
resolver
genesymbol_syn
CCD1
resolver
genesymbol_syn
KIAA1735
resolver
hgnc
HGNC:23695
resolver
uniprot
A1A5D8
resolver
uniprot
E9PRV4
resolver
uniprot
Q6P2J8
resolver
uniprot
Q6PIK4
resolver
uniprot
Q86SR7
resolver
uniprot
Q8IVY4
resolver
uniprot
Q96N69
resolver
uniprot
Q9C0C8
resolver
uniprot_entry
DIXC1_HUMAN
resolver
uniprot_sec
A1A5D8
resolver
uniprot_sec
E9PRV4
resolver
uniprot_sec
Q6P2J8
resolver
uniprot_sec
Q6PIK4
resolver
uniprot_sec
Q86SR7
resolver
uniprot_sec
Q8IVY4
resolver
uniprot_sec
Q96N69
resolver
uniprot_sec
Q9C0C8
resolver
amino_acid_sequence
MLACLTRGNLLDVLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQLSPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFKPGSSRTVNQGRDSRAPLQSHRPHCATAVAQGAAAALADVCHDMSRSGRDVFRYRQRNSSMDEEIENPYWSVRALVQQYEGQQRSPSESSCSSLTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRTQVGSEYRESWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGNHRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGEN
uniprot
proteins
function
FUNCTION: Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. {ECO:0000269|PubMed:15262978, ECO:0000269|PubMed:21189423}.
uniprot
proteins
mass_dalton
77478
uniprot
proteins
mutagenesis
MUTAGEN 648; /note="D->A: Loss of interaction with DVL2. Abolishes activation of Wnt signaling."; /evidence="ECO:0000269|PubMed:21189423"; MUTAGEN 651; /note="F->A: Loss of interaction with DVL2. Abolishes activation of Wnt signaling."; /evidence="ECO:0000269|PubMed:21189423"; MUTAGEN 655; /note="K->A: Loss of interaction with DVL2. Abolishes activation of Wnt signaling."; /evidence="ECO:0000269|PubMed:21189423
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine and serine residues. {ECO:0000269|PubMed:20085589}.; PTM: Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation. {ECO:0000269|PubMed:20085589}.
uniprot
proteins
protein_family
DIXDC1 family
uniprot
proteins
pubmed
11214970
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15262978
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16814745
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19375513
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20085589
uniprot
proteins
pubmed
20213681
uniprot
proteins
pubmed
21189423
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
683
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:16814745}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:16814745}. Cytoplasm {ECO:0000269|PubMed:20085589}. Note=Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis (PubMed:19375513). Associated with actin stress fiber at the filament ends (PubMed:16814745). {ECO:0000269|PubMed:16814745, ECO:0000269|PubMed:19375513}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16814745}. Note=Not associated with stress fibers. {ECO:0000269|PubMed:16814745}.
uniprot
proteins