BHLHE41
entrez
79365
canonical
uniprot
Q9C0J9
canonical
ensembl
ENSG00000123095
resolver
ensp
ENSP00000242728
resolver
enst
ENST00000242728
resolver
genesymbol
BHLHE41
resolver
genesymbol_syn
BHLHB3
resolver
genesymbol_syn
DEC2
resolver
genesymbol_syn
SHARP1
resolver
hgnc
HGNC:16617
resolver
uniprot
A2I2N8
resolver
uniprot
Q8TAT1
resolver
uniprot_entry
BHE41_HUMAN
resolver
uniprot_entry
Q8TAT1_HUMAN
resolver
uniprot_sec
A2I2N8
resolver
amino_acid_sequence
MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSMKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRCVQLINHLHAVATQFLPTPQLLTQQVPLSKGTGAPSAAGSAAAPCLERAGQKLEPLAYCVPVIQRTQPSAELAAENDTDTDSGYGGEAEARPDREKGKGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGGGPGGGAAAAAAALLGPDPAAAAALLRPDAALLSSLVAFGGGGGAPFPQPAAAAAPFCLPFCFLSPSAAAAYVQPFLDKSGLEKYLYPAAAAAPFPLLYPGIPAPAAAAAAAAAAAAAAAAFPCLSSVLSPPPEKAGAAAATLLPHEVAPLGAPHPQHPHGRTHLPFAGPREPGNPESSAQEDPSQPGKEAP
uniprot
proteins
function
FUNCTION: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:11278948, PubMed:14672706, PubMed:15193144, PubMed:15560782, PubMed:18411297, PubMed:19786558, PubMed:25083013). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:25083013). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11 (By similarity). {ECO:0000250|UniProtKB:Q99PV5, ECO:0000269|PubMed:11278948, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:15193144, ECO:0000269|PubMed:15560782, ECO:0000269|PubMed:18411297, ECO:0000269|PubMed:19786558, ECO:0000269|PubMed:25083013}.
uniprot
proteins
mass_dalton
50498
uniprot
proteins
mutagenesis
MUTAGEN 70..71; /note="LL->AA: Abolishes RXRA repression."; /evidence="ECO:0000269|PubMed:19786558
uniprot
proteins
pubmed
11162494
uniprot
proteins
pubmed
11278948
uniprot
proteins
pubmed
14672706
uniprot
proteins
pubmed
15193144
uniprot
proteins
pubmed
15560782
uniprot
proteins
pubmed
18411297
uniprot
proteins
pubmed
19679812
uniprot
proteins
pubmed
19786558
uniprot
proteins
pubmed
25083013
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
482
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
uniprot
proteins