Rrp9
entrez
27966
canonical
uniprot
Q91WM3
canonical
ensembl
ENSMUSG00000041506
resolver
ensp
ENSMUSP00000038580
resolver
enst
ENSMUST00000047721
resolver
genesymbol
Rrp9
resolver
genesymbol_syn
Rnu3ip2
resolver
genesymbol_syn
U3-55k
resolver
uniprot
Q8CFB7
resolver
uniprot_entry
U3IP2_MOUSE
resolver
uniprot_sec
Q8CFB7
resolver
amino_acid_sequence
MSTAVATRKRAKPAPGPGAAPVAGKRRRKVDSAADRGKSKGGGKMNEEISSDSESESLAPRKTEEEEEEELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKSVAKEIQAPAPTDIRVLRGHQLSITCLVITPDDLAIFSAAKDCTIIKWSVETGRKLHVIPRAKKGAQGQPAGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRKGTHQLYSTSHDRSVKVWNAAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLHGEPGLEQPFWVSSVAALLNTDLVATGSHNARVRLWQCGEGFRQLDPLCDIPLVGFINSLKFSSAGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPLRRLPVSPVAGS
uniprot
proteins
function
FUNCTION: Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000250|UniProtKB:O43818}.
uniprot
proteins
mass_dalton
52107
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-12 and Lys-25 by KAT2B/PCAF under stress impairs pre-rRNA processing. Deacetylation by SIRT7 enhances RRP9-binding to U3 snoRNA, which is a prerequisite for pre-rRNA processing. {ECO:0000250|UniProtKB:O43818}.
uniprot
proteins
protein_family
WD repeat RRP9 family
uniprot
proteins
pubmed
12448766
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
475
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:O43818}.
uniprot
proteins