Amn
entrez
93835
canonical
uniprot
Q99JB7
canonical
ensembl
ENSMUSG00000021278
resolver
ensp
ENSMUSP00000021707
resolver
enst
ENSMUST00000021707
resolver
genesymbol
Amn
resolver
uniprot
Q5I0U1
resolver
uniprot
Q99MP9
resolver
uniprot_entry
AMNLS_MOUSE
resolver
uniprot_sec
Q5I0U1
resolver
uniprot_sec
Q99MP9
resolver
amino_acid_sequence
MGALGRVLLWLQLCAMTRAAYKLWVPNTSFDTASNWNQNRTPCAGDAVQFPADKMVSVLVRDSHAISDMLLPLDGELVLASGAALSAAGGDSDPACNPGAPLLFRNPDRFSWLDPHLWSSGTQAPGLFSVDAERVPCSYDDVLFPRDGSFRVALGPGPNPVHVRSVSAVGQTFSRDEDLTAFLASREGRLRFHGSGALRVGSQACTDASGCVCGNAEMLPWICASLLQPLGGRCPQAACQDPLLPQGQCCDLCGAIVSLTHDPTFDLERYRARLLDLFLKQPQYQGLQVAVSKVLRDAHTEIQVVLVETEHATGAAGQLGHALLQDAVAQGSVLGIVSATLRQSGKPMTADSELNQSSSGAGLAGGVAALVLLALLGTVLLLLHRSGRLRWRRHEDAEPVSAGLPLGFRNPIFDAIVFKQQPSVELPDSAQKVDILDIDTKFGCFVNPLFAGEAEAEA
uniprot
proteins
function
FUNCTION: Membrane-bound component of the endocytic receptor formed by AMN and CUBN. Required for normal CUBN glycosylation and trafficking to the cell surface (PubMed:15342463). The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12 (By similarity). Required for normal CUBN-mediated protein transport in the kidney (PubMed:15342463). {ECO:0000250|UniProtKB:Q9BXJ7, ECO:0000269|PubMed:15342463}.
uniprot
proteins
mass_dalton
48696
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9BXJ7}.; PTM: A soluble form arises by proteolytic removal of the membrane anchor. {ECO:0000250|UniProtKB:Q9BXJ7}.
uniprot
proteins
pubmed
11279523
uniprot
proteins
pubmed
15342463
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9851841
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:15342463}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9BXJ7}. Cell membrane {ECO:0000250|UniProtKB:Q9BXJ7}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9BXJ7}. Endosome membrane {ECO:0000250|UniProtKB:Q9BXJ7}. Membrane, coated pit {ECO:0000250|UniProtKB:Q9BXJ7}.
uniprot
proteins
transmembrane_region
TRANSMEM 363..383; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins