Chka
entrez
29194
canonical
uniprot
Q01134
canonical
ensembl
ENSRNOG00000016791
resolver
ensp
ENSRNOP00000022824
resolver
ensp
ENSRNOP00000023020
resolver
ensp
ENSRNOP00000088950
resolver
enst
ENSRNOT00000096831
resolver
genesymbol
Chka
resolver
genesymbol_syn
Chk
resolver
genesymbol_syn
Ckr
resolver
uniprot
A0A8I6AJV1
resolver
uniprot
Q63114
resolver
uniprot
Q66HK1
resolver
uniprot_entry
A0A8I6AJV1_RAT
resolver
uniprot_entry
CHKA_RAT
resolver
uniprot_entry
Q66HK1_RAT
resolver
uniprot_sec
Q63114
resolver
amino_acid_sequence
MKTKFCTGGEAEPSPLGLLLSCGGSAAPTPGVGQQRDAAGELESKQLGGRSQPLALPPPPPPPLPLPPPPSPPLADEQPEPRTRRRAYLWCKEFLPGAWRGLREDQFHISVIRGGLSNMLFQCSLPDSIASVGDEPRKVLLRLYGAILKMRSCNKEGSEQAQNENEFQGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELCLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLNQVLRLKFSREARVQQLHKFLSYNLPLELENLRSLLQYTRSPVVFCHNDCQEGNILLLEGQENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYTYEKYPFFRANIQKYPTRKQQLHFISSYLTTFQNDFESLSSEEQSATKEDMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMEYAQARFDAYFDQKRKLGV
uniprot
proteins
ec_number
2.7.1.32
uniprot
proteins
ec_number
2.7.1.82
uniprot
proteins
function
FUNCTION: Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis. Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis. Has higher activity with choline. {ECO:0000250|UniProtKB:P35790}.; FUNCTION: [Isoform 1]: This isoform plays a key role in lipolysis of lipid droplets following glucose deprivation (By similarity). In response to glucose deprivation, phosphorylated by AMPK, promoting localization to lipid droplets (By similarity). Phosphorylation is followed by acetylation by KAT5, leading to dissociation of the homodimer into a monomer (By similarity). Monomeric CHKA isoform 1 is converted into a tyrosine-protein kinase, which phosphorylates lipid droplet structural proteins PLIN2 and PLIN3, leading to lipolysis of lipid droplets (By similarity). {ECO:0000250|UniProtKB:P35790}.
uniprot
proteins
mass_dalton
51824
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1. {ECO:0000250|UniProtKB:P35790}.; PATHWAY: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. {ECO:0000250|UniProtKB:P35790}.
uniprot
proteins
post_translational_modification
PTM: [Isoform 1]: Phosphorylated at Ser-275 by AMPK in response to glucose deprivation, leading to localization to lipid droplets. {ECO:0000250|UniProtKB:P35790}.; PTM: [Isoform 1]: Acetylated by KAT5 at Lys-243 following phosphorylation by AMPK, leading to monomerization and conversion into a tyrosine-protein kinase. {ECO:0000250|UniProtKB:P35790}.
uniprot
proteins
protein_family
Choline/ethanolamine kinase family
uniprot
proteins
pubmed
1577786
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7852267
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P35790}.; SUBCELLULAR LOCATION: [Isoform 1]: Lipid droplet {ECO:0000250|UniProtKB:P35790}. Note=Isoform 1 localizes to lipid droplets following phosphorylation by AMPK. {ECO:0000250|UniProtKB:P35790}.
uniprot
proteins