Cd19
entrez
12478
canonical
uniprot
P25918
canonical
ensembl
ENSMUSG00000030724
resolver
ensp
ENSMUSP00000032968
resolver
ensp
ENSMUSP00000145803
resolver
enst
ENSMUST00000032968
resolver
enst
ENSMUST00000206325
resolver
genesymbol
Cd19
resolver
uniprot
A0A0X1KG58
resolver
uniprot
Q3TQG5
resolver
uniprot
Q542B2
resolver
uniprot_entry
A0A0X1KG58_MOUSE
resolver
uniprot_entry
CD19_MOUSE
resolver
uniprot_entry
Q3TQG5_MOUSE
resolver
uniprot_sec
Q542B2
resolver
amino_acid_sequence
MPSPLPVSFLLFLTLVGGRPQKSLLVEVEEGGNVVLPCLPDSSPVSSEKLAWYRGNQSTPFLELSPGSPGLGLHVGSLGILLVIVNVSDHMGGFYLCQKRPPFKDIWQPAWTVNVEDSGEMFRWNASDVRDLDCDLRNRSSGSHRSTSGSQLYVWAKDHPKVWGTKPVCAPRGSSLNQSLINQDLTVAPGSTLWLSCGVPPVPVAKGSISWTHVHPRRPNVSLLSLSLGGEHPVREMWVWGSLLLLPQATALDEGTYYCLRGNLTIERHVKVIARSAVWLWLLRTGGWIVPVVTLVYVIFCMVSLVAFLYCQRAFILRRKRKRMTDPARRFFKVTPPSGNGTQNQYGNVLSLPTSTSGQAHAQRWAAGLGSVPGSYGNPRIQVQDTGAQSHETGLEEEGEAYEEPDSEEGSEFYENDSNLGQDQVSQDGSGYENPEDEPMGPEEEDSFSNAESYENADEELAQPVGRMMDFLSPHGSAWDPSREASSLGSQSYEDMRGILYAAPQLHSIQSGPSHEEDADSYENMDKSDDLEPAWEGEGHMGTWGTT
uniprot
proteins
function
FUNCTION: Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:12387743, PubMed:20101619, PubMed:9382888). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:7542548, PubMed:7543183, PubMed:9317126). Required for normal differentiation of B-1 cells (PubMed:12387743, PubMed:7542548, PubMed:7543183). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:12387743, PubMed:7542548, PubMed:9317126). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:12387743, PubMed:7542548, PubMed:7543183). {ECO:0000250|UniProtKB:P15391, ECO:0000269|PubMed:12387743, ECO:0000269|PubMed:20101619, ECO:0000269|PubMed:7542548, ECO:0000269|PubMed:7543183, ECO:0000269|PubMed:9317126, ECO:0000269|PubMed:9382888}.
uniprot
proteins
mass_dalton
60149
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine following B-cell activation (PubMed:20101619). Phosphorylated on tyrosine residues by LYN (By similarity). Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-522 is extremely rapid, followed by phosphorylation at Tyr-402. In contrast, phosphorylation of Tyr-493 appears more slowly and is more transient, returning rapidly to basal levels (PubMed:20101619). {ECO:0000250|UniProtKB:P15391, ECO:0000269|PubMed:20101619}.
uniprot
proteins
pubmed
12387743
uniprot
proteins
pubmed
1370948
uniprot
proteins
pubmed
1375324
uniprot
proteins
pubmed
15378723
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1714482
uniprot
proteins
pubmed
20101619
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2472450
uniprot
proteins
pubmed
7542548
uniprot
proteins
pubmed
7543183
uniprot
proteins
pubmed
9317126
uniprot
proteins
pubmed
9382888
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12387743, ECO:0000269|PubMed:20101619, ECO:0000269|PubMed:7543183}; Single-pass type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:20101619}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 288..311; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins