Mmel1
entrez
27390
canonical
uniprot
Q9JLI3
canonical
ensembl
ENSMUSG00000058183
resolver
ensp
ENSMUSP00000078252
resolver
ensp
ENSMUSP00000131753
resolver
enst
ENSMUST00000079269
resolver
enst
ENSMUST00000163732
resolver
genesymbol
Mmel1
resolver
genesymbol_syn
Nep2
resolver
genesymbol_syn
Nl1
resolver
genesymbol_syn
Sep
resolver
uniprot
B1AS15
resolver
uniprot
E9PVK7
resolver
uniprot
Q3U495
resolver
uniprot
Q9ERK2
resolver
uniprot
Q9ERK3
resolver
uniprot
Q9QZV6
resolver
uniprot
Q9QZV7
resolver
uniprot_entry
B1AS15_MOUSE
resolver
uniprot_entry
MMEL1_MOUSE
resolver
uniprot_sec
E9PVK7
resolver
uniprot_sec
Q3U495
resolver
uniprot_sec
Q9ERK2
resolver
uniprot_sec
Q9ERK3
resolver
uniprot_sec
Q9QZV6
resolver
uniprot_sec
Q9QZV7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by thiorphan and phosphoramidon. {ECO:0000269|PubMed:11278416}.
uniprot
proteins
amino_acid_sequence
MVERAGWCRKKSPGFVEYGLMVLLLLLLGAIVTLGVFYSIGKQLPLLTSLLHFSWDERTVVKRALRDSSLKSDICTTPSCVIAAARILENMDQSRNPCENFYQYACGGWLRHHVIPETNSRYSVFDILRDELEVILKGVLEDSTSQHRPAVEKAKTLYRSCMNQSVIEKRDSEPLLSVLKMVGGWPVAMDKWNETMGLKWELERQLAVLNSQFNRRVLIDLFIWNDDQNSSRHVIYIDQPTLGMPSREYYFQEDNNHKVRKAYLEFMTSVATMLRKDQNLSKESAMVREEMAEVLELETHLANATVPQEKRHDVTALYHRMDLMELQERFGLKGFNWTLFIQNVLSSVEVELFPDEEVVVYGIPYLENLEDIIDSYSARTMQNYLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTVEEVRWRECVSYVNSNMESAVGSLYIKRAFSKDSKSTVRELIEKIRSVFVDNLDELNWMDEESKKKAQEKAMNIREQIGYPDYILEDNNKHLDEEYSSLTFYEDLYFENGLQNLKNNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKDQPQSLNFGGIGMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSARHFQQQSQCMIYQYGNFSWELADNQNVNGFSTLGENIADNGGVRQAYKAYLRWLADGGKDQRLPGLNLTYAQLFFINYAQVWCGSYRPEFAVQSIKTDVHSPLKYRVLGSLQNLPGFSEAFHCPRGSPMHPMKRCRIW
uniprot
proteins
ec_number
3.4.24.11
uniprot
proteins
function
FUNCTION: Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond. {ECO:0000269|PubMed:10542292, ECO:0000269|PubMed:11278416}.
uniprot
proteins
mass_dalton
88700
uniprot
proteins
mutagenesis
MUTAGEN 62..63; /note="KR->NG: Abolishes formation the soluble form."; /evidence="ECO:0000269|PubMed:10749671
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10542292, ECO:0000269|PubMed:10749671}.
uniprot
proteins
protein_family
Peptidase M13 family
uniprot
proteins
pubmed
10542292
uniprot
proteins
pubmed
10749671
uniprot
proteins
pubmed
11278416
uniprot
proteins
pubmed
15121861
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
765
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10542292}; Single-pass type II membrane protein {ECO:0000269|PubMed:10542292}. Secreted {ECO:0000269|PubMed:10542292}. Note=A secreted form produced by proteolytic cleavage also exists.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins