Adcyap1
entrez
24166
canonical
uniprot
P13589
canonical
ensembl
ENSRNOG00000049882
resolver
ensembl
ENSRNOG00055007690
resolver
ensembl
ENSRNOG00060004749
resolver
ensembl
ENSRNOG00065009286
resolver
ensp
ENSRNOP00000063920
resolver
ensp
ENSRNOP00055010254
resolver
ensp
ENSRNOP00060005959
resolver
ensp
ENSRNOP00065011093
resolver
enst
ENSRNOT00055012866
resolver
enst
ENSRNOT00060007935
resolver
enst
ENSRNOT00065014840
resolver
genesymbol
Adcyap1
resolver
uniprot_entry
PACA_RAT
resolver
amino_acid_sequence
MTMCSGARLALLVYGIIMHNSVSCSPAAGLSFPGIRPEEEAYDQDGNPLQDFYDWDPPGAGSPASALRDAYALYYPADRRDVAHEILNEAYRKVLDQLSARKYLQSMVARGMGENLAAAAVDDRAPLTKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL
uniprot
proteins
function
FUNCTION: PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (PubMed:23800469). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (PubMed:18198219). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). PACAP exists in two bioactive forms from proteolysis of the same precursor protein, PACAP27 and PACAP38, which differ by eleven amino acid residues in the C-terminus (By similarity). {ECO:0000250|UniProtKB:O70176, ECO:0000250|UniProtKB:P18509, ECO:0000269|PubMed:18198219, ECO:0000269|PubMed:23800469}.
uniprot
proteins
mass_dalton
19557
uniprot
proteins
protein_family
Glucagon family
uniprot
proteins
pubmed
18198219
uniprot
proteins
pubmed
2268329
uniprot
proteins
pubmed
23800469
uniprot
proteins
pubmed
2803320
uniprot
proteins
pubmed
7835287
uniprot
proteins
sequence_length
175
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins