AQP11
entrez
282679
canonical
uniprot
Q8NBQ7
canonical
ensembl
ENSG00000178301
resolver
ensp
ENSP00000318770
resolver
ensp
ENSP00000549056
resolver
enst
ENST00000313578
resolver
genesymbol
AQP11
resolver
genesymbol_syn
AQPX1
resolver
hgnc
HGNC:19940
resolver
uniprot_entry
AQP11_HUMAN
resolver
amino_acid_sequence
MSPLLGLRSELQDTCTSLGLMLSVVLLMGLARVVARQQLHRPVAHAFVLEFLATFQLCCCTHELQLLSEQHPAHPTWTLTLVYFFSLVHGLTLVGTSSNPCGVMMQMMLGGMSPETGAVRLLAQLVSALCSRYCTSALWSLGLTQYHVSERSFACKNPIRVDLLKAVITEAVCSFLFHSALLHFQEVRTKLRIHLLAALITFLVYAGGSLTGAVFNPALALSLHFMCFDEAFPQFFIVYWLAPSLGILLMILMFSFFLPWLHNNHTINKKE
uniprot
proteins
function
FUNCTION: Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain (PubMed:24845055, PubMed:24918044, PubMed:31546170). In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (PubMed:31546170). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (By similarity). Plays a role in the proximal tubule function by regulating its endosomal acidification (By similarity). May play a role in postnatal kidney development (By similarity). {ECO:0000250|UniProtKB:Q8BHH1, ECO:0000269|PubMed:24845055, ECO:0000269|PubMed:24918044, ECO:0000269|PubMed:31546170}.
uniprot
proteins
mass_dalton
30203
uniprot
proteins
mutagenesis
MUTAGEN 227; /note="C->A: Does not affect endoplasmic reticulum localization. Does not affect trafficking to the plasma membrane. Increases osmotic water permeability. Decreases homomultimerization."; /evidence="ECO:0000269|PubMed:24918044"; MUTAGEN 227; /note="C->S: Does not affect endoplasmic reticulum localization. Does not affect trafficking to the plasma membrane. Reduces protein expression. Increases osmotic water permeability."; /evidence="ECO:0000269|PubMed:24918044
uniprot
proteins
post_translational_modification
PTM: Not glycosylated. {ECO:0000269|PubMed:31546170}.
uniprot
proteins
protein_family
AQP11/AQP12 subfamily
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
19812234
uniprot
proteins
pubmed
24845055
uniprot
proteins
pubmed
24918044
uniprot
proteins
pubmed
28042826
uniprot
proteins
pubmed
31546170
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24918044, ECO:0000269|PubMed:31546170}; Multi-pass membrane protein {ECO:0000269|PubMed:24918044}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:28042826}; Multi-pass membrane protein {ECO:0000269|PubMed:24918044}. Cell membrane {ECO:0000250|UniProtKB:F6S3G9}; Multi-pass membrane protein {ECO:0000269|PubMed:24918044}. Note=Localizes mainly to the periphery of lipid droplets (PubMed:24845055). Localizes to cytoplasmic vesicles in maturing spermatozoa (PubMed:28042826). It accumulates partly in mitochondrial-associated endoplasmic reticulum membranes (PubMed:31546170). {ECO:0000269|PubMed:24845055, ECO:0000269|PubMed:28042826, ECO:0000269|PubMed:31546170}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..35; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 42..62; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 75..95; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 164..184; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 195..215; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 235..255; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins