F2R
entrez
2149
canonical
uniprot
P25116
canonical
ensembl
ENSG00000181104
resolver
ensp
ENSP00000321326
resolver
enst
ENST00000319211
resolver
genesymbol
F2R
resolver
genesymbol_syn
CF2R
resolver
genesymbol_syn
PAR1
resolver
genesymbol_syn
TR
resolver
hgnc
HGNC:3537
resolver
uniprot
Q53XV0
resolver
uniprot
Q96RF7
resolver
uniprot
Q9BUN4
resolver
uniprot_entry
PAR1_HUMAN
resolver
uniprot_sec
Q53XV0
resolver
uniprot_sec
Q96RF7
resolver
uniprot_sec
Q9BUN4
resolver
amino_acid_sequence
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
uniprot
proteins
function
FUNCTION: High affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores (PubMed:1672265, PubMed:8136362). The thrombin-activated receptor signaling pathway is mediated through PTX-insensitive G proteins, activation of phospholipase C resulting in the production of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) which binds to InsP3 receptors causing calcium release from the stores (By similarity). In astrocytes, the calcium released into the cytosol allows the Ca(2+)-dependent release of L-glutamate into the synaptic cleft through BEST1, that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (By similarity). May play a role in platelets activation and in vascular development (PubMed:10079109). Mediates up-regulation of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, triggered by coagulation factor Xa (F10) in cardiac fibroblasts and umbilical vein endothelial cells (PubMed:30568593, PubMed:34831181). {ECO:0000250|UniProtKB:P26824, ECO:0000250|UniProtKB:P30558, ECO:0000269|PubMed:10079109, ECO:0000269|PubMed:1672265, ECO:0000269|PubMed:30568593, ECO:0000269|PubMed:34831181, ECO:0000269|PubMed:8136362}.
uniprot
proteins
mass_dalton
47441
uniprot
proteins
mutagenesis
MUTAGEN 41; /note="R->A: Abolished and activation cleavage by GZMK."; /evidence="ECO:0000269|PubMed:35881628"; MUTAGEN 55..56; /note="FW->AA: Abolishes cleavage by CTSG but not by thrombin."; /evidence="ECO:0000269|PubMed:7744748
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage by thrombin generates a new N-terminus that functions as a tethered ligand (PubMed:1672265, PubMed:7744748). Also proteolytically cleaved by cathepsin CTSG (PubMed:7744748). Cleavage at 41-Arg-|-Ser-42 by CTSG and GZMK results in receptor activation while cleavage at 55-Phe-|-Trp-56 results in inhibition of receptor activation (PubMed:35881628, PubMed:7744748). {ECO:0000269|PubMed:1672265, ECO:0000269|PubMed:35881628, ECO:0000269|PubMed:7744748}.; PTM: Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and internalization of the receptor. {ECO:0000269|PubMed:8955127}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10079109
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1672265
uniprot
proteins
pubmed
18988770
uniprot
proteins
pubmed
22659187
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30568593
uniprot
proteins
pubmed
34831181
uniprot
proteins
pubmed
35738824
uniprot
proteins
pubmed
35881628
uniprot
proteins
pubmed
7744748
uniprot
proteins
pubmed
8136362
uniprot
proteins
pubmed
8955127
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P26824}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P26824}.
uniprot
proteins
transmembrane_region
TRANSMEM 103..128; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 138..157; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 177..198; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 269..288; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 312..334; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 351..374; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins