RNASE1
entrez
6035
canonical
uniprot
P07998
canonical
ensembl
ENSG00000129538
resolver
ensp
ENSP00000344193
resolver
ensp
ENSP00000381057
resolver
ensp
ENSP00000381060
resolver
ensp
ENSP00000399493
resolver
ensp
ENSP00000554142
resolver
ensp
ENSP00000554143
resolver
ensp
ENSP00000554144
resolver
ensp
ENSP00000554145
resolver
ensp
ENSP00000554146
resolver
ensp
ENSP00000554147
resolver
ensp
ENSP00000554148
resolver
ensp
ENSP00000630546
resolver
ensp
ENSP00000630547
resolver
ensp
ENSP00000630548
resolver
enst
ENST00000340900
resolver
enst
ENST00000397967
resolver
enst
ENST00000397970
resolver
enst
ENST00000412779
resolver
enst
ENST00000884083
resolver
enst
ENST00000884084
resolver
enst
ENST00000884085
resolver
enst
ENST00000884086
resolver
enst
ENST00000884087
resolver
enst
ENST00000884088
resolver
enst
ENST00000884089
resolver
enst
ENST00000960487
resolver
enst
ENST00000960488
resolver
enst
ENST00000960489
resolver
genesymbol
RNASE1
resolver
genesymbol_syn
RIB1
resolver
genesymbol_syn
RNS1
resolver
hgnc
HGNC:10044
resolver
uniprot
B2R589
resolver
uniprot
D3DS06
resolver
uniprot
Q16830
resolver
uniprot
Q16869
resolver
uniprot
Q1KHR2
resolver
uniprot
Q6ICS5
resolver
uniprot
Q9UCB4
resolver
uniprot
Q9UCB5
resolver
uniprot_entry
RNAS1_HUMAN
resolver
uniprot_sec
B2R589
resolver
uniprot_sec
D3DS06
resolver
uniprot_sec
Q16830
resolver
uniprot_sec
Q16869
resolver
uniprot_sec
Q1KHR2
resolver
uniprot_sec
Q6ICS5
resolver
uniprot_sec
Q9UCB4
resolver
uniprot_sec
Q9UCB5
resolver
amino_acid_sequence
MALEKSLVRLLLLVLILLVLGWVQPSLGKESRAKKFQRQHMDSDSSPSSSSTYCNQMMRRRNMTQGRCKPVNTFVHEPLVDVQNVCFQEKVTCKNGQGNCYKSNSSMHITDCRLTNGSRYPNCAYRTSPKERHIIVACEGSPYVPVHFDASVEDST
uniprot
proteins
ec_number
4.6.1.18
uniprot
proteins
function
FUNCTION: Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA. {ECO:0000269|PubMed:17350650}.
uniprot
proteins
mass_dalton
17644
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="R->D: Substantially decreases binding affinity for RNH1 but maintains high conformational stability; when associated with D-95, A-116, D-117 and D-119."; /evidence="ECO:0000269|PubMed:17350650"; MUTAGEN 95; /note="N->D: Substantially decreases binding affinity for RNH1 but maintains high conformational stability; when associated with D-67, A-116, D-117 and D-119."; /evidence="ECO:0000269|PubMed:17350650"; MUTAGEN 116..117; /note="NG->RS: No effect on inhibition by RNH1."; /evidence="ECO:0000269|PubMed:11021969"; MUTAGEN 116; /note="N->A: Substantially decreases binding affinity for RNH1 but maintains high conformational stability; when associated with D-67, D-95, D-117 and D-119."; /evidence="ECO:0000269|PubMed:17350650"; MUTAGEN 117; /note="G->D: Substantially decreases binding affinity for RNH1 but maintains high conformational stability; when associated with D-67, D-95, A-116 and D-119."; /evidence="ECO:0000269|PubMed:17350650"; MUTAGEN 119; /note="R->D: Substantially decreases binding affinity for RNH1 but maintains high conformational stability; when associated with D-67, D-95, A-116 and D-117."; /evidence="ECO:0000269|PubMed:17350650
uniprot
proteins
post_translational_modification
PTM: N-linked glycans are of complex type. {ECO:0000269|PubMed:3202829}.
uniprot
proteins
protein_family
Pancreatic ribonuclease family
uniprot
proteins
pubmed
11021969
uniprot
proteins
pubmed
11264578
uniprot
proteins
pubmed
11591351
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1587793
uniprot
proteins
pubmed
16751256
uniprot
proteins
pubmed
17350650
uniprot
proteins
pubmed
1741299
uniprot
proteins
pubmed
17586772
uniprot
proteins
pubmed
2049798
uniprot
proteins
pubmed
2383019
uniprot
proteins
pubmed
3202829
uniprot
proteins
pubmed
6201087
uniprot
proteins
pubmed
7649283
uniprot
proteins
pubmed
8049276
uniprot
proteins
pubmed
8280059
uniprot
proteins
pubmed
8588814
uniprot
proteins
sequence_length
156
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins