Cd70
entrez
21948
canonical
uniprot
O55237
canonical
ensembl
ENSMUSG00000019489
resolver
ensp
ENSMUSP00000019633
resolver
enst
ENSMUST00000019633
resolver
genesymbol
Cd70
resolver
genesymbol_syn
Cd27l
resolver
genesymbol_syn
Cd27lg
resolver
genesymbol_syn
Tnfsf7
resolver
genesymbol_syn
Tnlg8a
resolver
uniprot
Q05A52
resolver
uniprot_entry
CD70_MOUSE
resolver
uniprot_entry
Q05A52_MOUSE
resolver
amino_acid_sequence
MPEEGRPCPWVRWSGTAFQRQWPWLLLVVFITVFCCWFHCSGLLSKQQQRLLEHPEPHTAELQLNLTVPRKDPTLRWGAGPALGRSFTHGPELEEGHLRIHQDGLYRLHIQVTLANCSSPGSTLQHRATLAVGICSPAAHGISLLRGRFGQDCTVALQRLTYLVHGDVLCTNLTLPLLPSRNADETFFGVQWICP
uniprot
proteins
function
FUNCTION: Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells. The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells. {ECO:0000269|PubMed:9366422, ECO:0000269|PubMed:9620608}.
uniprot
proteins
mass_dalton
21919
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:9366422}.
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
9366422
uniprot
proteins
pubmed
9620608
uniprot
proteins
sequence_length
195
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9366422, ECO:0000269|PubMed:9620608}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..44; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins