LLGL2
entrez
3993
canonical
uniprot
Q6P1M3
canonical
ensembl
ENSG00000073350
resolver
ensp
ENSP00000167462
resolver
ensp
ENSP00000364375
resolver
ensp
ENSP00000376333
resolver
ensp
ENSP00000464397
resolver
ensp
ENSP00000580166
resolver
ensp
ENSP00000580168
resolver
ensp
ENSP00000580169
resolver
ensp
ENSP00000580172
resolver
ensp
ENSP00000580174
resolver
ensp
ENSP00000603887
resolver
ensp
ENSP00000603889
resolver
ensp
ENSP00000603890
resolver
ensp
ENSP00000626347
resolver
ensp
ENSP00000666159
resolver
ensp
ENSP00000706287
resolver
ensp
ENSP00000706288
resolver
enst
ENST00000577200
resolver
enst
ENST00000910107
resolver
enst
ENST00000910113
resolver
enst
ENST00000933828
resolver
enst
ENST00000933830
resolver
enst
ENST00000933831
resolver
enst
ENST00000956288
resolver
genesymbol
LLGL2
resolver
hgnc
HGNC:6629
resolver
uniprot
A0PJJ0
resolver
uniprot
J3QRV5
resolver
uniprot
Q14521
resolver
uniprot
Q9BR62
resolver
uniprot_entry
A0PJJ0_HUMAN
resolver
uniprot_entry
J3QRV5_HUMAN
resolver
uniprot_entry
L2GL2_HUMAN
resolver
uniprot_sec
Q14521
resolver
uniprot_sec
Q9BR62
resolver
amino_acid_sequence
MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDPNENFSAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEAAEQAVEQVEADLLQDQEGYRWKGHERLAARSGPVRFEPGFQPFVLVQCQPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRMRRSRVSSRKRHPAGPPGEAQEGSAKAERPGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLKDSSRHCPSLWAGTNGGTIYAFSLRVPPAERRMDEPVRAEQAKEIQLMHRAPVVGILVLDGHSVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSAKLKLKLTALEGSRVRRVSVAHFGSRRAEDYGEHHLAVLTNLGDIQVVSLPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYLISPSEFERFSLSTKWLVEPRCLVDSAETKNHRPGNGAGPKKAPSRARNSGTQSDGEEKQPGLVMERALLSDERVLKEIQSTLEGDRGSGNWRSHRAAVGCSLSNGGAE
uniprot
proteins
function
FUNCTION: Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269|PubMed:15632202}.
uniprot
proteins
mass_dalton
113448
uniprot
proteins
mutagenesis
MUTAGEN 641; /note="S->A: No effect on phosphorylation."; /evidence="ECO:0000269|PubMed:12725730"; MUTAGEN 645; /note="S->A: Decrease of phosphorylation."; /evidence="ECO:0000269|PubMed:12725730"; MUTAGEN 649; /note="S->A: Decrease of phosphorylation."; /evidence="ECO:0000269|PubMed:12725730"; MUTAGEN 653; /note="S->A: Loss of phosphorylation."; /evidence="ECO:0000269|PubMed:12725730"; MUTAGEN 660; /note="S->A: Decrease of phosphorylation."; /evidence="ECO:0000269|PubMed:12725730"; MUTAGEN 663; /note="S->A: No effect on phosphorylation."; /evidence="ECO:0000269|PubMed:12725730
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-653 by PRKCI. Phosphorylation is enhanced during cell polarization induced by calcium. Phosphorylation may occur during the cell-cell contact-induced cell polarization and may contribute to the segregation of LLGL2 from the PRKCI/aPKC and PARD6B/Par-6 complex. {ECO:0000269|PubMed:12725730}.
uniprot
proteins
protein_family
WD repeat L(2)GL family
uniprot
proteins
pubmed
12725730
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15632202
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20644714
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
1020
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15632202}. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.
uniprot
proteins