Grik2
entrez
54257
canonical
uniprot
P42260
canonical
ensembl
ENSRNOG00000000368
resolver
ensembl
ENSRNOG00055012181
resolver
ensembl
ENSRNOG00060006459
resolver
ensembl
ENSRNOG00065000469
resolver
ensp
ENSRNOP00000068172
resolver
ensp
ENSRNOP00055016735
resolver
ensp
ENSRNOP00060007944
resolver
ensp
ENSRNOP00065000562
resolver
enst
ENSRNOT00000076234
resolver
enst
ENSRNOT00055020749
resolver
enst
ENSRNOT00060010716
resolver
enst
ENSRNOT00065000683
resolver
genesymbol
Grik2
resolver
genesymbol_syn
Glur6
resolver
uniprot_entry
GRIK2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Ionotropic glutamate receptor activity is promoted by positive allosteric modulators such as the lectin concanavalin A and BPAM344 that inhibit receptor desensitization (PubMed:39592599, PubMed:38778115). Ionotropic glutamate receptor activity is inhibited by ion channel blockers such as kukoamine A and spermine (PubMed:39592599).Cold receptor activity is activated by temperatures between 10-19 degrees Celsius (By similarity). {ECO:0000250|UniProtKB:P39087, ECO:0000269|PubMed:38778115, ECO:0000269|PubMed:39592599}.
uniprot
proteins
amino_acid_sequence
MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA
uniprot
proteins
function
FUNCTION: Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid (PubMed:1648177, PubMed:1322826, PubMed:7681676, PubMed:7678465, PubMed:39592599, PubMed:38778115). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system (PubMed:1322826, PubMed:17486098, PubMed:25139762). Binding of the excitatory neurotransmitter L-glutamate induces a conformational change leading to the opening of the cation channel, converting the chemical signal to an electrical impulse (PubMed:39592599, PubMed:38778115). The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:1322826, PubMed:1648177, PubMed:17115050, PubMed:17486098, PubMed:25139762, PubMed:7678465, PubMed:7681676, PubMed:8163463). Modulates cell surface expression of NETO2 (By similarity). In association with GRIK3, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity). {ECO:0000250|UniProtKB:P39087, ECO:0000269|PubMed:1322826, ECO:0000269|PubMed:1648177, ECO:0000269|PubMed:17115050, ECO:0000269|PubMed:17486098, ECO:0000269|PubMed:25139762, ECO:0000269|PubMed:38778115, ECO:0000269|PubMed:39592599, ECO:0000269|PubMed:7678465, ECO:0000269|PubMed:7681676, ECO:0000269|PubMed:8163463}.; FUNCTION: Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (By similarity). Functions in dorsal root ganglion neurons (By similarity). {ECO:0000250|UniProtKB:P39087}.
uniprot
proteins
mass_dalton
102470
uniprot
proteins
mutagenesis
MUTAGEN 378; /note="N->Q: Impairs ionotropic glutamate receptor activity."; /evidence="ECO:0000269|PubMed:38778115"; MUTAGEN 546; /note="N->Q: Impairs ionotropic glutamate receptor activity; on its own or when associated with Q-751."; /evidence="ECO:0000269|PubMed:38778115"; MUTAGEN 751; /note="N->Q: Loss of glycosylation. Impairs ionotropic glutamate receptor activity; on its own or when associated with Q-546."; /evidence="ECO:0000269|PubMed:38778115, ECO:0000269|PubMed:8163463"; MUTAGEN 883; /note="V->A: Abolishes interaction with KLHL17. Abolishes actinfilin-mediated degradation."; /evidence="ECO:0000269|PubMed:17062563"; MUTAGEN 884; /note="I->A: Abolishes interaction with KLHL17. Abolishes actinfilin-mediated degradation."; /evidence="ECO:0000269|PubMed:17062563"; MUTAGEN 886; /note="K->R: Abolishes sumoylation. Loss of kainate-mediated endocytosis."; /evidence="ECO:0000269|PubMed:17486098
uniprot
proteins
post_translational_modification
PTM: Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1. {ECO:0000269|PubMed:17486098}.; PTM: Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome. {ECO:0000269|PubMed:17062563}.; PTM: Phosphorylated by PKC at Ser-868 upon agonist activation, this directly enhance sumoylation. {ECO:0000250|UniProtKB:Q13002}.
uniprot
proteins
protein_family
GRIK2 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
11744724
uniprot
proteins
pubmed
1322826
uniprot
proteins
pubmed
15677325
uniprot
proteins
pubmed
15721240
uniprot
proteins
pubmed
1648177
uniprot
proteins
pubmed
17062563
uniprot
proteins
pubmed
17115050
uniprot
proteins
pubmed
17486098
uniprot
proteins
pubmed
19217376
uniprot
proteins
pubmed
21791290
uniprot
proteins
pubmed
22509486
uniprot
proteins
pubmed
25139762
uniprot
proteins
pubmed
38778115
uniprot
proteins
pubmed
39592599
uniprot
proteins
pubmed
7678465
uniprot
proteins
pubmed
7681676
uniprot
proteins
pubmed
8163463
uniprot
proteins
sequence_length
908
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17486098, ECO:0000269|PubMed:22509486, ECO:0000269|PubMed:8163463}; Multi-pass membrane protein {ECO:0000269|PubMed:38778115, ECO:0000269|PubMed:39592599}. Postsynaptic cell membrane {ECO:0000269|PubMed:17486098}; Multi-pass membrane protein {ECO:0000269|PubMed:38778115, ECO:0000269|PubMed:39592599}.
uniprot
proteins
transmembrane_region
TRANSMEM 552..585; /note="Helical; Name=M1"; /evidence="ECO:0000269|PubMed:38778115, ECO:0000269|PubMed:39592599, ECO:0007744|PDB:9B36, ECO:0007744|PDB:9B37, ECO:0007744|PDB:9B38, ECO:0007744|PDB:9B39, ECO:0007744|PDB:9DXQ, ECO:0007744|PDB:9DXR, ECO:0007744|PDB:9DXS, ECO:0007744|PDB:9DXT"; TRANSMEM 630..660; /note="Helical; Name=M3"; /evidence="ECO:0000269|PubMed:38778115, ECO:0000269|PubMed:39592599, ECO:0007744|PDB:9B36, ECO:0007744|PDB:9B37, ECO:0007744|PDB:9B38, ECO:0007744|PDB:9B39, ECO:0007744|PDB:9DXQ, ECO:0007744|PDB:9DXR, ECO:0007744|PDB:9DXS, ECO:0007744|PDB:9DXT"; TRANSMEM 816..840; /note="Helical; Name=M4"; /evidence="ECO:0000269|PubMed:38778115, ECO:0000269|PubMed:39592599, ECO:0007744|PDB:9B36, ECO:0007744|PDB:9B37, ECO:0007744|PDB:9B38, ECO:0007744|PDB:9B39, ECO:0007744|PDB:9DXQ, ECO:0007744|PDB:9DXR, ECO:0007744|PDB:9DXS, ECO:0007744|PDB:9DXT
uniprot
proteins