Tbc1d20
entrez
67231
canonical
uniprot
Q9D9I4
canonical
ensembl
ENSMUSG00000027465
resolver
ensp
ENSMUSP00000028963
resolver
enst
ENSMUST00000028963
resolver
genesymbol
Tbc1d20
resolver
uniprot
Q0P648
resolver
uniprot
Q3TYW9
resolver
uniprot
Q99LW2
resolver
uniprot_entry
Q0P648_MOUSE
resolver
uniprot_entry
TBC20_MOUSE
resolver
uniprot_sec
Q3TYW9
resolver
uniprot_sec
Q99LW2
resolver
amino_acid_sequence
MALRPSKGDGSAGRWDRGAGKADFNAKRKKKVAEIHQALNSDPIDLAALRRMAISEGGLLTDEIRCQVWPKLLNVNTSEPPPVSRKDLRDMSKDYQQVLLDVRRSLRRFPPGMPDEQREGLQEELIDIILLVLDRNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVSPELHDFMQSAEVGTIFALSWLITWFGHVLMDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAREAAAQQEAERTAASTFKDFELASTQQRPDMVLRQRFRGLLRPEARTKDVLTKPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Tbc1d20 are the cause of spontaneous autosomal recessive blind sterile (bs) phenotype. Bs animals exhibit embryonic non-progressive nuclear cataracts and spermatid abnormalities associated with male infertility.
uniprot
proteins
function
FUNCTION: GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude (By similarity). Also shows GAP activity for RAB18 GTPase (PubMed:26063829). Promotes RAB18 dissociation from the endoplasmic reticulum (ER) membrane into the cytosol, probably through stimulating RAB18 GTP-hydrolysis (PubMed:26063829). Involved in maintaining endoplasmic reticulum structure (By similarity). {ECO:0000250|UniProtKB:Q96BZ9, ECO:0000269|PubMed:26063829}.
uniprot
proteins
mass_dalton
45825
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24239381
uniprot
proteins
pubmed
26063829
uniprot
proteins
sequence_length
402
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 237..257; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 366..386; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins