Tfb2m
entrez
15278
canonical
uniprot
Q3TL26
canonical
ensembl
ENSMUSG00000026492
resolver
ensp
ENSMUSP00000027769
resolver
ensp
ENSMUSP00000317162
resolver
ensp
ENSMUSP00000342477
resolver
enst
ENSMUST00000027769
resolver
genesymbol
Tfb2m
resolver
uniprot
B2RSE6
resolver
uniprot
Q61669
resolver
uniprot
Q8BTJ2
resolver
uniprot_entry
B2RSE6_MOUSE
resolver
uniprot_entry
TFB2M_MOUSE
resolver
uniprot_sec
Q61669
resolver
uniprot_sec
Q8BTJ2
resolver
amino_acid_sequence
MRGPAMRLPPRIALSALARGPSCILGSGAATRKDWQTRNRRGFSDFNIEPLPDSDLEESSPWTSRNRSEPTRHIACKKAARNLVRDLLEHQNPSRQIILECNPGPGILTGALLKAGARVVAFESEKTFIPHLEPLQRNMDGELQVVHCDFFKMDPRYQEVVRPDVSSQAIFQNLGIKAVPWSAGVPIKVFGILPYKHERRILWKILFDLYSCESIYRYGRVELNMFVSEKEFRKLIATPKRPDLYQVMAVLWQVACDVKFLHMEPWSSFSVHTENGHLEKSKHGESVNLLKQNLYLVRMTPRRTLFTENLSPLNYDIFFHLVKHCFGKRNAPIIRHLRSLSTVDPINILRQIRKNPGDTAARMYPHDFKKLFETIEQSEDSVFKWIYDYCPEDMEF
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (By similarity). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:15526033). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:15526033). Stimulates transcription independently of the methyltransferase activity (By similarity). {ECO:0000250|UniProtKB:Q9H5Q4, ECO:0000269|PubMed:15526033}.
uniprot
proteins
mass_dalton
45864
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
KsgA subfamily
uniprot
proteins
protein_family
rRNA adenine N(6)-methyltransferase family
uniprot
proteins
pubmed
12532263
uniprot
proteins
pubmed
15526033
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
uniprot
proteins