FUNDC2
entrez
65991
canonical
uniprot
Q9BWH2
canonical
ensembl
ENSG00000165775
resolver
ensp
ENSP00000358510
resolver
ensp
ENSP00000526582
resolver
ensp
ENSP00000612626
resolver
enst
ENST00000369498
resolver
enst
ENST00000856523
resolver
enst
ENST00000942567
resolver
genesymbol
FUNDC2
resolver
genesymbol_syn
HCBP6
resolver
hgnc
HGNC:24925
resolver
uniprot
B2R7W5
resolver
uniprot
D3DWY5
resolver
uniprot
Q8NHX8
resolver
uniprot
Q9H2I6
resolver
uniprot_entry
FUND2_HUMAN
resolver
uniprot_sec
B2R7W5
resolver
uniprot_sec
D3DWY5
resolver
uniprot_sec
Q8NHX8
resolver
uniprot_sec
Q9H2I6
resolver
amino_acid_sequence
METSAPRAGSQVVATTARHSAAYRADPLRVSSRDKLTEMAASSQGNFEGNFESLDLAEFAKKQPWWRKLFGQESGPSAEKYSVATQLFIGGVTGWCTGFIFQKVGKLAATAVGGGFFLLQLANHTGYIKVDWQRVEKDMKKAKEQLKIRKSNQIPTEVRSKAEEVVSFVKKNVLVTGGFFGGFLLGMAS
uniprot
proteins
function
FUNCTION: Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (PubMed:29786068). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (PubMed:25855506, PubMed:29187281). {ECO:0000269|PubMed:25855506, ECO:0000269|PubMed:29187281, ECO:0000269|PubMed:29786068}.
uniprot
proteins
mass_dalton
20676
uniprot
proteins
protein_family
FUN14 family
uniprot
proteins
pubmed
12665903
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25855506
uniprot
proteins
pubmed
29187281
uniprot
proteins
pubmed
29786068
uniprot
proteins
pubmed
30576423
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:29786068}; Multi-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000305|PubMed:29187281}.
uniprot
proteins
transmembrane_region
TRANSMEM 81..101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 108..128; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins