Adra1d
entrez
29413
canonical
uniprot
P23944
canonical
ensembl
ENSRNOG00000021256
resolver
ensp
ENSRNOP00000028877
resolver
enst
ENSRNOT00000028877
resolver
genesymbol
Adra1d
resolver
genesymbol_syn
Adra1a
resolver
uniprot
G3V8W0
resolver
uniprot
Q71UM4
resolver
uniprot_entry
ADA1D_RAT
resolver
uniprot_entry
G3V8W0_RAT
resolver
uniprot_sec
Q71UM4
resolver
amino_acid_sequence
MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKPASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDYSNLRETDI
uniprot
proteins
function
FUNCTION: Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11) (PubMed:1334487). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C (PubMed:1334487). ADRA1D binds the catecholamine ligands norepinephrine and epinephrine (By similarity). {ECO:0000250|UniProtKB:P25100, ECO:0000269|PubMed:1334487}.
uniprot
proteins
mass_dalton
59354
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Palmitoylation by ZDHHC21 may increase the expression of the receptor and regulate downstream signaling. {ECO:0000250|UniProtKB:P97714}.
uniprot
proteins
protein_family
ADRA1D sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10570042
uniprot
proteins
pubmed
1334487
uniprot
proteins
pubmed
1661838
uniprot
proteins
pubmed
1706716
uniprot
proteins
pubmed
7815325
uniprot
proteins
sequence_length
561
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 91..115; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 128..153; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 164..186; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 208..232; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 246..269; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 343..367; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 375..399; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins