Kiz
entrez
228730
canonical
uniprot
Q3UXL4
canonical
ensembl
ENSMUSG00000074749
resolver
ensp
ENSMUSP00000096884
resolver
ensp
ENSMUSP00000196483
resolver
ensp
ENSMUSP00000196484
resolver
enst
ENSMUST00000099278
resolver
genesymbol
Kiz
resolver
genesymbol_syn
Gm114
resolver
genesymbol_syn
Plk1s1
resolver
uniprot
A2AUS7
resolver
uniprot
B2RX19
resolver
uniprot_entry
KIZ_MOUSE
resolver
uniprot_sec
A2AUS7
resolver
uniprot_sec
B2RX19
resolver
amino_acid_sequence
MPRGRGGGGGGLRQASATSAPLASPSYYERVGQLQQALRDSEKKRLDLEDKLYEYNKSDKCRAKLKCAKLKKYLKEVCESERRAQVRNQGYLKKFECVQTYVEHLTTNTEKLQKLKTEYEAEVKRMRLLSKDSLGMSDEDGAKDAVQAGINSGTAMSRGLYQPATIFMGRQMSAISSIEDFSTELKSNQPTKNFSISDPHSHQQTAQSSCVTDSCVVQTNGDTQCLNKSDKIHGKTSLQTGEKAPVTSYVLSAEEQTHCLEIGSSTQHSKSNLSEGRKSAELHSSLQERLSPENSITDLKCDSSSRSEGSDREILTQEHIEVREERAGPLVPMMAASEHCTSAKKWAGEKHSAWEASSDDLDHGDSKSQKAVLKHEEEQEEGSSCSSSDLTVSVSEDDLILESLAALSNPGAKMAGKDGMQALRAAHTEPRQDSLFTEYVLQTQSFPDSKREPSPDSPRQPEKVPDCHLLKTRGQCMKEHDNSLKEEATTLLKKVLTEECDHRSAIHSNESSCSMPSILNDNNGIKEAKPALRLNSVLTREQEVSSGCGDESKEESIAAAPGTGHREADLVPSELFQFSLGAAMKETKAYQLLKKSTLQDNSNQAEERFESQFSGLDIGGSMFTTKTAHKIASEASFSSSEGSPLSRHESKRDPVTTIKSNAFWGESDDSNSEIEAALRPRDHDMPDDFDDFYDT
uniprot
proteins
function
FUNCTION: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000250|UniProtKB:Q2M2Z5}.
uniprot
proteins
mass_dalton
76542
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-391 by PLK1 is not needed for centrosomal localization or pericentriolar material expansion but is indispensable for spindle-pole stabilization. {ECO:0000250|UniProtKB:Q2M2Z5}.
uniprot
proteins
protein_family
Kizuna family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
695
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q2M2Z5}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q2M2Z5}. Note=Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome- surrounding area in a microtubule-independent and dependent manner, respectively. {ECO:0000250|UniProtKB:Q2M2Z5}.
uniprot
proteins