Slc29a1
entrez
63997
canonical
uniprot
O54698
canonical
ensembl
ENSRNOG00000019752
resolver
ensembl
ENSRNOG00055007373
resolver
ensembl
ENSRNOG00060019889
resolver
ensembl
ENSRNOG00065024920
resolver
ensp
ENSRNOP00000026831
resolver
ensp
ENSRNOP00055009762
resolver
ensp
ENSRNOP00060028482
resolver
ensp
ENSRNOP00065035168
resolver
enst
ENSRNOT00000026831
resolver
enst
ENSRNOT00055012311
resolver
enst
ENSRNOT00060034685
resolver
enst
ENSRNOT00065042968
resolver
genesymbol
Slc29a1
resolver
genesymbol_syn
Ent1
resolver
uniprot_entry
S29A1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Transport activity is sensitive to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR). {ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:9353301}.
uniprot
proteins
amino_acid_sequence
MTTSHQPQDRYKAVWLIFFVLGLGTLLPWNFFITATQYFTSRLNTSQNISLVTNQSCESTEALADPSVSLPARSSLSAIFNNVMTLCAMLPLLIFTCLNSFLHQKVSQSLRILGSLLAILLVFLVTATLVKVQMDALSFFIITMIKIVLINSFGAILQASLFGLAGVLPANYTAPIMSGQGLAGFFTSVAMICAVASGSKLSESAFGYFITACAVVILAILCYLALPWMEFYRHYLQLNLAGPAEQETKLDLISEGEEPRGGREESGVPGPNSLPANRNQSIKAILKSIWVLALSVCFIFTVTIGLFPAVTAEVESSIAGTSPWKNCYFIPVACFLNFNVFDWLGRSLTAICMWPGQDSRWLPVLVACRVVFIPLLMLCNVKQHHYLPSLFKHDVWFITFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGNIMSFFLCLGLALGAVLSFLLRALV
uniprot
proteins
function
FUNCTION: Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:9353301). Functions as a Na(+)-independent transporter (By similarity). Involved in the transport of nucleosides such as adenosine, thymidine and uridine (PubMed:23639800, PubMed:9353301). Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (By similarity). Also mediates the uptake of nicotinamide; contributes to maintaining nicotinamide homeostasis but also regulated nicotinamide biological roles (By similarity). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (PubMed:23639800). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (By similarity). {ECO:0000250|UniProtKB:Q99808, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:9353301}.
uniprot
proteins
mass_dalton
50017
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="I->M: Increase in the sensitivities to dipyridamole and dilazep."; /evidence="ECO:0000269|PubMed:17379602"; MUTAGEN 335; /note="F->Y: Increase in the transport capacity for adenosine but no change in substrate affinity. Increase in the sensitivities to dipyridamole and dilazep."; /evidence="ECO:0000269|PubMed:17379602"; MUTAGEN 339; /note="N->C: Increase in the sensitivities to dipyridamole and dilazep."; /evidence="ECO:0000269|PubMed:17379602
uniprot
proteins
protein_family
SLC29A/ENT transporter (TC 2.A.57) family
uniprot
proteins
pubmed
11584005
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17379602
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23639800
uniprot
proteins
pubmed
9353301
uniprot
proteins
sequence_length
457
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:23639800}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:Q99808}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:11584005}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the basolateral membrane of Sertoli cells. {ECO:0000269|PubMed:23639800}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..36; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 80..103; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 109..131; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 141..163; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 173..194; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 203..224; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 289..312; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 330..351; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 360..378; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 395..417; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q99808"; TRANSMEM 432..451; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q99808
uniprot
proteins