RTN4RL2
entrez
349667
canonical
uniprot
Q86UN3
canonical
ensembl
ENSG00000186907
resolver
ensp
ENSP00000335397
resolver
genesymbol
RTN4RL2
resolver
genesymbol_syn
NGRH1
resolver
genesymbol_syn
NGRL3
resolver
hgnc
HGNC:23053
resolver
uniprot
Q0GGW3
resolver
uniprot
Q17RL9
resolver
uniprot
Q6X813
resolver
uniprot_entry
R4RL2_HUMAN
resolver
uniprot_sec
Q0GGW3
resolver
uniprot_sec
Q17RL9
resolver
uniprot_sec
Q6X813
resolver
amino_acid_sequence
MLPGLRRLLQAPASACLLLMLLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLRALREADFQACPPAAPTRPGSRARGNSSSNHLYGVAEAGAPPADPSTLYRDLPAEDSRGRQGGDAPTEDDYWGGYGGEDQRGEQMCPGAACQAPPDSRGPALSAGLPSPLLCLLLLVPHHL
uniprot
proteins
function
FUNCTION: Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). {ECO:0000250|UniProtKB:Q7M6Z0, ECO:0000250|UniProtKB:Q80WD1, ECO:0000269|PubMed:22325200}.
uniprot
proteins
mass_dalton
46106
uniprot
proteins
post_translational_modification
PTM: Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; is released both as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein. {ECO:0000269|PubMed:15629437}.; PTM: N-glycosylated. {ECO:0000269|PubMed:15629437}.
uniprot
proteins
protein_family
Nogo receptor family
uniprot
proteins
pubmed
12694398
uniprot
proteins
pubmed
12839991
uniprot
proteins
pubmed
14664809
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15629437
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
22325200
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12694398, ECO:0000269|PubMed:12839991}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12694398}. Membrane raft {ECO:0000269|PubMed:12694398}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7M6Z0}. Perikaryon {ECO:0000250|UniProtKB:Q80WD1}. Cell projection, axon {ECO:0000250|UniProtKB:Q80WD1}. Note=Localized to the surface of neurons, including axons. Detected close to synapses, but is excluded from synapses. {ECO:0000250|UniProtKB:Q7M6Z0}.
uniprot
proteins