Slc36a2
entrez
246235
canonical
uniprot
Q8K415
canonical
ensembl
ENSRNOG00000011892
resolver
ensp
ENSRNOP00000016440
resolver
enst
ENSRNOT00000016440
resolver
genesymbol
Slc36a2
resolver
genesymbol_syn
Pat2
resolver
genesymbol_syn
Tramd1
resolver
uniprot
B2GUU7
resolver
uniprot
F7FGD4
resolver
uniprot_entry
B2GUU7_RAT
resolver
uniprot_entry
F7FGD4_RAT
resolver
uniprot_entry
S36A2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by L- and D-pipecolic acid, nipecotic acid, isonipecotic acid, L- and D-cycloserine, and L-2-azetidine-carboxylate. {ECO:0000269|PubMed:15644866}.
uniprot
proteins
amino_acid_sequence
MSVTKSAGSPQVAATVKLDLVSFPESAKKVQSQDPNPVNGSSSESSEKTKGITGFQTLVHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGLIACHCMHILVRCAQRFCHRLNKPFMDYGDTVMHGLASSPNTWLQSHAHWGRHAVSFFLIVTQLGFCCVYIVFLADNLKQVVEAVNSTTISCHKNETVVLTPTIDSRLYMLAFLPVLGLLVFIRNLRVLTIFSLLANVSMLVSLVIIGQYIIQGIPDPSQLPLVASWKTYPLFFGTAIFSFESIGVVLPLENKMKDARRFPTILSLGMSIITTLYIAIGALGYLRFGDDIKASITLNLPNCWLYQSVKLLYVVGILCTHALQFYVPAEIIIPLAVSQVSKRWALPVDLSIRLALVCVTCMLAILIPRLDLVLSLVGSVSSSALALIIPPLLEVTTYYGEGMSPLTITKDALISILGFMGFVVGTYQALDELIRSGNSLPLSNSTMFIQ
uniprot
proteins
function
FUNCTION: Electrogenic proton/amino acid symporter with a high selectivity for the small side chains amino acids glycine, alanine and proline, where both L- and D-enantiomers are transported. Extension of the backbone length, as in beta-alanine and 4-aminobutanoate or methylation of the amino group, as in sarcosine and N,N-dimethylglycine, are also tolerated but decrease transport efficiency. A free carboxyl group is preferred. {ECO:0000269|PubMed:12727219, ECO:0000269|PubMed:15644866}.
uniprot
proteins
mass_dalton
52278
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
pubmed
12451123
uniprot
proteins
pubmed
12727219
uniprot
proteins
pubmed
15644866
uniprot
proteins
sequence_length
481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12727219, ECO:0000269|PubMed:15644866}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BHK3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q8BHK3}.
uniprot
proteins
transmembrane_region
TRANSMEM 57..77; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 80..100; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 147..167; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 221..241; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 263..283; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 296..316; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 378..398; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 403..423; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 445..465; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins