O88942
uniprot
O88942
canonical
amino_acid_sequence
MPNTSFPVPSKFPLGPPAAVCGSGETLRPAPPSGGTMKAAEEEHYSYVSPSVTSTLPLPTAHSALPAACHDLQTSTPGISAVPSANHPPSYGGAVDSGPSGYFLSSGNTRPNGAPTLESPRIEITSYLGLHHGSGQFFHDVEVEDVLPSCKRSPSTATLHLPSLEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRSLGACHLLGSPRHSPSTSPRASITEESWLGARGSRPTSPCNKRKYSLNGRQPSCSPHHSPTPSPHGSPRVSVTEDTWLGNTTQYTSSAIVAAINALTTDSTLDLGDGVPIKSRKTALEHAPSVALKVEPAGEDLGTTPPTSDFPPEEYTFQHLRKGAFCEQYLSVPQASYQWAKPKSLSPTSYMSPSLPALDWQLPSHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLTLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEIILSNTKVLEIPLLPENNMRAIIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPNGRTLSLQVASNPIECSQRSAQELPLVEKQSTDSYPVIGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPAQVSFYVCNGKRKRSQYQRFTYLPANGNSVFLTLSSESELRGGFY
uniprot
proteins
function
FUNCTION: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription (PubMed:9388475). Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (By similarity). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (PubMed:23990468, PubMed:26644563). {ECO:0000250|UniProtKB:O95644, ECO:0000269|PubMed:23990468, ECO:0000269|PubMed:9388475, ECO:0000303|PubMed:26644563}.
uniprot
proteins
mass_dalton
77833
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NFATC-kinase and GSK3B; phosphorylation induces NFATC1 nuclear exit and dephosphorylation by calcineurin promotes nuclear import. Phosphorylation by PKA and DYRK2 negatively modulates nuclear accumulation, and promotes subsequent phosphorylation by GSK3B or casein kinase 1 (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
10072529
uniprot
proteins
pubmed
16968888
uniprot
proteins
pubmed
17198697
uniprot
proteins
pubmed
17579027
uniprot
proteins
pubmed
19626032
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21435446
uniprot
proteins
pubmed
21514407
uniprot
proteins
pubmed
23478294
uniprot
proteins
pubmed
23990468
uniprot
proteins
pubmed
24039232
uniprot
proteins
pubmed
24970700
uniprot
proteins
pubmed
26644563
uniprot
proteins
pubmed
28341745
uniprot
proteins
pubmed
32741026
uniprot
proteins
pubmed
9388475
uniprot
proteins
sequence_length
717
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19626032, ECO:0000269|PubMed:24970700, ECO:0000269|PubMed:28341745, ECO:0000269|PubMed:32741026}. Nucleus {ECO:0000269|PubMed:19626032, ECO:0000269|PubMed:21514407, ECO:0000269|PubMed:23990468, ECO:0000269|PubMed:24039232, ECO:0000269|PubMed:26644563, ECO:0000269|PubMed:28341745, ECO:0000269|PubMed:32741026}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. Translocation to the nucleus is increased in the presence of calcium in pre-osteoblasts (PubMed:21514407). The subcellular localization of NFATC plays a key role in the regulation of gene transcription (By similarity). Nuclear translocation of NFATC1 is enhanced in the presence of TNFSF11 (PubMed:26644563). Nuclear translocation is decreased in the presence of FBN1 which can bind and sequester TNFSF11 (PubMed:24039232). {ECO:0000250|UniProtKB:O95644, ECO:0000269|PubMed:21514407, ECO:0000269|PubMed:24039232, ECO:0000269|PubMed:26644563}.
uniprot
proteins