HRH1
entrez
3269
canonical
uniprot
P35367
canonical
ensembl
ENSG00000196639
resolver
ensp
ENSP00000380247
resolver
ensp
ENSP00000397028
resolver
ensp
ENSP00000406705
resolver
ensp
ENSP00000573259
resolver
ensp
ENSP00000573260
resolver
ensp
ENSP00000573261
resolver
ensp
ENSP00000573262
resolver
ensp
ENSP00000573263
resolver
ensp
ENSP00000573264
resolver
ensp
ENSP00000573265
resolver
ensp
ENSP00000573266
resolver
ensp
ENSP00000628998
resolver
ensp
ENSP00000628999
resolver
ensp
ENSP00000629000
resolver
enst
ENST00000397056
resolver
enst
ENST00000431010
resolver
enst
ENST00000438284
resolver
enst
ENST00000903200
resolver
enst
ENST00000903201
resolver
enst
ENST00000903202
resolver
enst
ENST00000903203
resolver
enst
ENST00000903204
resolver
enst
ENST00000903205
resolver
enst
ENST00000903206
resolver
enst
ENST00000903207
resolver
enst
ENST00000958939
resolver
enst
ENST00000958940
resolver
enst
ENST00000958941
resolver
genesymbol
HRH1
resolver
hgnc
HGNC:5182
resolver
uniprot
A8K047
resolver
uniprot
Q6P9E5
resolver
uniprot_entry
HRH1_HUMAN
resolver
uniprot_sec
A8K047
resolver
uniprot_sec
Q6P9E5
resolver
amino_acid_sequence
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}.
uniprot
proteins
mass_dalton
55784
uniprot
proteins
mutagenesis
MUTAGEN 56; /note="R->A: No effect on activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 57; /note="K->A: No effect on activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 59; /note="H->A: No effect on activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 107; /note="D->A,E: Loss of activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 108; /note="Y->F: No effect on activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 108; /note="Y->V: Decreased activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 111; /note="S->A: No effect on activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 112; /note="T->A: Decreased activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 135; /note="Y->A: No effect on activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 137; /note="K->A: No effect on activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 158; /note="W->A: Loss of activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 198; /note="N->A: Loss of activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 428; /note="W->A: Loss of activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 431; /note="Y->F: Loss of activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 431; /note="Y->R: Increased histamine receptor activity. Constitutively active."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 432; /note="F->A: No effect on activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 435; /note="F->A: Decreased activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 454; /note="I->A: No effect on activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 458; /note="Y->A: Decreased activation by histamine."; /evidence="ECO:0000269|PubMed:33828102"; MUTAGEN 458; /note="Y->F: No effect on activation by histamine."; /evidence="ECO:0000269|PubMed:33828102
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor down-regulation. {ECO:0000269|PubMed:15328002}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15014171
uniprot
proteins
pubmed
15328002
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
21697825
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
33828102
uniprot
proteins
pubmed
7925364
uniprot
proteins
pubmed
8003029
uniprot
proteins
pubmed
8280179
uniprot
proteins
sequence_length
487
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21697825}; Multi-pass membrane protein {ECO:0000269|PubMed:21697825}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical; Name=1"; /evidence="ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL"; TRANSMEM 65..89; /note="Helical; Name=2"; /evidence="ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL"; TRANSMEM 98..123; /note="Helical; Name=3"; /evidence="ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL"; TRANSMEM 145..164; /note="Helical; Name=4"; /evidence="ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL"; TRANSMEM 189..211; /note="Helical; Name=5"; /evidence="ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL"; TRANSMEM 417..440; /note="Helical; Name=6"; /evidence="ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL"; TRANSMEM 447..469; /note="Helical; Name=7"; /evidence="ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL
uniprot
proteins