Nat1
entrez
116631
canonical
uniprot
P50297
canonical
ensembl
ENSRNOG00000049498
resolver
ensembl
ENSRNOG00055004106
resolver
ensembl
ENSRNOG00060017218
resolver
ensembl
ENSRNOG00065004978
resolver
ensp
ENSRNOP00000018854
resolver
ensp
ENSRNOP00000070053
resolver
ensp
ENSRNOP00000086542
resolver
ensp
ENSRNOP00000086645
resolver
ensp
ENSRNOP00000108530
resolver
ensp
ENSRNOP00055005010
resolver
ensp
ENSRNOP00055005012
resolver
ensp
ENSRNOP00055005013
resolver
ensp
ENSRNOP00055005015
resolver
ensp
ENSRNOP00060023644
resolver
ensp
ENSRNOP00060023653
resolver
ensp
ENSRNOP00060023675
resolver
ensp
ENSRNOP00060023680
resolver
ensp
ENSRNOP00065005040
resolver
ensp
ENSRNOP00065005046
resolver
ensp
ENSRNOP00065005050
resolver
ensp
ENSRNOP00065005053
resolver
ensp
ENSRNOP00065005054
resolver
ensp
ENSRNOP00065005056
resolver
ensp
ENSRNOP00065005058
resolver
enst
ENSRNOT00000018854
resolver
enst
ENSRNOT00000090726
resolver
enst
ENSRNOT00000098891
resolver
enst
ENSRNOT00000107612
resolver
enst
ENSRNOT00000143414
resolver
enst
ENSRNOT00055006559
resolver
enst
ENSRNOT00055006561
resolver
enst
ENSRNOT00055006562
resolver
enst
ENSRNOT00055006564
resolver
enst
ENSRNOT00060029403
resolver
enst
ENSRNOT00060029417
resolver
enst
ENSRNOT00060029452
resolver
enst
ENSRNOT00060029458
resolver
enst
ENSRNOT00065007264
resolver
enst
ENSRNOT00065007270
resolver
enst
ENSRNOT00065007274
resolver
enst
ENSRNOT00065007277
resolver
enst
ENSRNOT00065007278
resolver
enst
ENSRNOT00065007280
resolver
enst
ENSRNOT00065007282
resolver
genesymbol
Nat1
resolver
genesymbol_syn
Aac1
resolver
genesymbol_syn
Nat2
resolver
uniprot
Q45G61
resolver
uniprot
Q45G71
resolver
uniprot_entry
ARY1_RAT
resolver
uniprot_entry
Q45G61_RAT
resolver
uniprot_entry
Q45G71_RAT
resolver
amino_acid_sequence
MDIEAYFERIGYKNSVNKLDLATLTEVLQHQMRAVPFENLSMHCGEAMCLGLEATFDHIVRKKRGGWCLQVNHLLYWALTKMGFETTMLGGYVYITPVNKYSSEMVHLLVQVTISDRNYIVDSAYGSSYQMWEPLELTSGKDQPQVPAIFRLTEENGTWYLDQIRREQDVPNQEFVNSDLLEKSKYRKIYSFTLEPRTIEDFEYVNTYLQTSPASVFVSTSFCSLQTSEGVCCLIGSTLTSRRFSYKDNVDLVEFKSLTEEEIEDVLKTTFGISLEKKFVPKHGELVFTI
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.118
uniprot
proteins
ec_number
2.3.1.5
uniprot
proteins
function
FUNCTION: Xenobiotic-metabolizing enzyme that catalyzes both N-acetylation (usually detoxification) and O-acetylation (usually bioactivation) of a wide range of species-specific substrates including hydrazines, aromatic amine drugs and aromatic amine carcinogens (PubMed:7882993, PubMed:8761433). Transfers an acetyl group from acetyl-coenzyme A to arylamine and N-hydroxyarylamine acceptor substrates (PubMed:7882993, PubMed:8761433). Can also transfer an N-acetyl group from an N-hydroxy acetylamine to either N-hydroxyarylamine or arylamine in the absence of acetyl-coenzyme A (PubMed:8761433). Therefore, activates N-hydroxyarylamines to unstable acetoxy intermediates which decompose to electrophiles, bind to DNA, and lead to mutagenesis and carcinogenesis (PubMed:8761433). Plays a significant role in the bioactivation and detoxification of many drugs and carcinogens (PubMed:7882993, PubMed:8761433). {ECO:0000269|PubMed:7882993, ECO:0000269|PubMed:8761433}.
uniprot
proteins
mass_dalton
33437
uniprot
proteins
protein_family
Arylamine N-acetyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7882993
uniprot
proteins
pubmed
8761433
uniprot
proteins
sequence_length
290
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P50294}.
uniprot
proteins