Spocd1
entrez
622480
canonical
uniprot
B1ASB6
canonical
ensembl
ENSMUSG00000028784
resolver
ensp
ENSMUSP00000081284
resolver
genesymbol
Spocd1
resolver
uniprot_entry
SPOC1_MOUSE
resolver
amino_acid_sequence
MPVDKFLARAGGQRTLSRFQDSLCDFLATGSSRSLCGTSLDFPDRVLVCTEGPAGMEEASSPSFRQATTVEGMVSPEDPTLSKEGLSAKGPPPSPVLPPFRRKCRKCGICPQEEEKSGFSLRFGQRPDGDPPECASPEAFAGPPRLLSSKDTEPGEPGGSWVECAVETEVENMLFSKDGVAPDSLDHLFEFPGLFGGEPLSLVTQEPLQSPALYPEVLTEDSTDQQEVQPAFVVGSPGTPPDPVGPEDKAQSGSRMELEQGLSAPANSCASSPEPLGGLDGAPLEQRRPTHVKKRPWTSPDDSSQDHAEGASKKDFPRLEARVPRGVKTVYYVYTGSGIRLVGAASSSQPGQIEPLEELDTNSARRKRRPTTAHPTPCQSDPSETENAEPHQQRAEDPGEQGMTPLDAGVRSTVVRAMQEVLWTRAQELPDLALREDEVEAIAEGIEEALFHLTQDTNLRYKNKYRSLLFNLRDPRNVDLFLKVAHCDVTPNNLVQMSSIQLAPKELSRWRDQEERKGLDIIEQQQKELYRLPASKLTHKGEVEIPRDLDQMLTLEDLMEPIVPRECSLQPLSTPLEDTTNWHQHHQCDSNCQICTGGEEGRKADDGSQPELQVDISYNVDRKSSTKLPAFSGVIMNREENAIQKAPGPAPASSPEVLKVGETPPKEPQDRLQMPAGLKNAPPSPPPWEGSLDMFSIKHFRAKAQLISGHSCQLVQALPDVIRSAGRLPPSHVWDLLDSMGPSKAKDICVIRLCPHGSRDIQNYRLLYSYLNNKQCHCLATVQQVKMVLLPLPAFEPLPARLRPLGGPGLEITHTSLLLAVLFPKDALPDTATSIPVSNKVPKTVSFSKRVERILYSPEDRRSEATSSPLEEDPKQSLARGSLAPRSVCAPQSFPRGRGRQGPGWGQWSPEAAWCYSQHPSSAGPVFPGIGQGQHLHRASCFHHDLLQHLKVLVTMSHQFQASLWPQSQDSLPPSTVVSAVPDPPGPSLGPMDGGGSNCPPPEGSDPLEPPEHEC
uniprot
proteins
function
FUNCTION: Protein adapter that acts as an essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (PubMed:32674113, PubMed:38359823, PubMed:39294378). Recruited to young transposons, which are specifically marked with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3), via its association with SPIN1 chromatin reader, and associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes (PubMed:32674113, PubMed:39294378). Following this, PIWIL4 engages with nascent transposable element transcript to direct piRNA-directed DNA methylation (PubMed:39294378). Not required for piRNA biosynthesis (PubMed:32674113). {ECO:0000269|PubMed:32674113, ECO:0000269|PubMed:38359823, ECO:0000269|PubMed:39294378}.
uniprot
proteins
mass_dalton
110815
uniprot
proteins
mutagenesis
MUTAGEN 338..347; /note="GIRLVGAASS->AAAAAAAAAA: Abolished interaction with Spin1. Knockin mice are viable and healthy but show male sterility due to defects in spermatogenesis."; /evidence="ECO:0000269|PubMed:39294378
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
32674113
uniprot
proteins
pubmed
38359823
uniprot
proteins
pubmed
39294378
uniprot
proteins
sequence_length
1015
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32674113}. Chromosome {ECO:0000269|PubMed:32674113, ECO:0000269|PubMed:39294378}.
uniprot
proteins