Tmc8
entrez
217356
canonical
uniprot
Q7TN58
canonical
ensembl
ENSMUSG00000050106
resolver
ensp
ENSMUSP00000051878
resolver
ensp
ENSMUSP00000101941
resolver
ensp
ENSMUSP00000113570
resolver
ensp
ENSMUSP00000251698
resolver
ensp
ENSMUSP00000251700
resolver
ensp
ENSMUSP00000339051
resolver
enst
ENSMUST00000117781
resolver
genesymbol
Tmc8
resolver
genesymbol_syn
Ever2
resolver
uniprot
B0QZP6
resolver
uniprot
B0QZP7
resolver
uniprot
B1ATC0
resolver
uniprot
Q3TAL0
resolver
uniprot
Q3UWI0
resolver
uniprot
Q7TQ67
resolver
uniprot_entry
B0QZP6_MOUSE
resolver
uniprot_entry
B0QZP7_MOUSE
resolver
uniprot_entry
B1ATC0_MOUSE
resolver
uniprot_entry
TMC8_MOUSE
resolver
uniprot_sec
Q3TAL0
resolver
uniprot_sec
Q3UWI0
resolver
uniprot_sec
Q7TQ67
resolver
amino_acid_sequence
MFRQWSVQSGPAPRRPESQAASEELWEQEVERLCASRTPVRMLPYAMADKRFIRELREPEGVKTTFWQRWHRPRRVARQHLREAEQRLARGFGLWEGALYEIGGLFGTGIQSYFTFLRFLLLLNLLTMLLTACFVLLPLVWLRPPELGPALKLRLQCSSSPLPQSDIPRFHNPLWNILTGRAFNNTYLFYGAYRAGPESSSEYSIRLAYLLSPMVCLLLCFCGILQRMAEGLPQQTLLGQRYRTPLSAKVFSSWDFCIRVWEAATIKKHEISNELKMELEEGRRVELAQQQTRAQKACRLLTYLRTNILIVLLVVGAISAIFWATKYSQDNKEESLFLVLQYLPPGVISLVNFLGPQLFTVLIQLENYPPGTEVNLTLIWCVVLKLASLGMFSFSLGQTVLCIGRNKTSCESYGYNACDYQCWENSVGEELYKLIIFNFLLTVAFAFLVSLPRRLLVERFSGWFWTWLDREEFLVPKNVLDIVAAQTVTWMGLFYCPLLPLLNSVFLFLTFYIKKYTLLRNSRASPRRFRASSSTFFFHLVLLLGLLLAAVPLAYVISSTHSSWDCGLFTNYSAPWQVVPELVALQLPLPSQRALRYLSSHAFSFPLLILLSIVLTVCISQSRANARAIQGLRKQLVWQVQEKWHLVDDLSRLLPELSPEPGSPHSRASRPRSFCPGFPCPGSPGPRTPRLAPSNRLSSSSLGAPSASVPASRFHFPSRTEL
uniprot
proteins
function
FUNCTION: Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:32917726). Together with its homolog TMC6/EVER1, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 levels and reciprocally (PubMed:32917726). Together with TMC6, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (By similarity). Also inhibits receptor-mediated calcium release from ER stores and calcium activated and volume regulated chloride channels (By similarity). Down-regulates the activity of transcription factors induced by zinc and cytokines (By similarity). Also sequesters TRADD which impairs the recruitment of TRAF2 and RIPK1 in the pro-survival complex I and promotes proapoptotic complex II formation, and may therefore be involved in TNF-induced cell death/survival decisions (By similarity). {ECO:0000250|UniProtKB:Q8IU68, ECO:0000269|PubMed:32917726}.
uniprot
proteins
mass_dalton
82329
uniprot
proteins
protein_family
TMC family
uniprot
proteins
pubmed
12812529
uniprot
proteins
pubmed
12906855
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32917726
uniprot
proteins
sequence_length
722
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8IU68}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8IU68}; Multi-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:Q8IU68}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 119..139; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 205..225; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 308..328; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 376..396; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 431..451; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 493..513; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 537..557; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 599..619; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins