Plat
entrez
18791
canonical
uniprot
P11214
canonical
ensembl
ENSMUSG00000031538
resolver
ensp
ENSMUSP00000033941
resolver
ensp
ENSMUSP00000248922
resolver
ensp
ENSMUSP00000248930
resolver
enst
ENSMUST00000033941
resolver
genesymbol
Plat
resolver
uniprot
Q6P7U0
resolver
uniprot
Q91VP2
resolver
uniprot_entry
TPA_MOUSE
resolver
uniprot_sec
Q6P7U0
resolver
uniprot_sec
Q91VP2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by SERPINA5 (By similarity). Inhibited by SERPINE1 (By similarity). {ECO:0000250|UniProtKB:P00750}.
uniprot
proteins
amino_acid_sequence
MKRELLCVLLLCGLAFPLPDQGIHGRFRRGARSYRATCRDEPTQTTYQQHQSWLRPMLRSSRVEYCRCNSGLVQCHSVPVRSCSEPRCFNGGTCQQALYFSDFVCQCPDGFVGKRCDIDTRATCFEEQGITYRGTWSTAESGAECINWNSSVLSLKPYNARRPNAIKLGLGNHNYCRNPDRDLKPWCYVFKAGKYTTEFCSTPACPKGKSEDCYVGKGVTYRGTHSLTTSQASCLPWNSIVLMGKSYTAWRTNSQALGLGRHNYCRNPDGDARPWCHVMKDRKLTWEYCDMSPCSTCGLRQYKRPQFRIKGGLYTDITSHPWQAAIFVKNKRSPGERFLCGGVLISSCWVLSAAHCFLERFPPNHLKVVLGRTYRVVPGEEEQTFEIEKYIVHEEFDDDTYDNDIALLQLRSQSKQCAQESSSVGTACLPDPNLQLPDWTECELSGYGKHEASSPFFSDRLKEAHVRLYPSSRCTSQHLFNKTVTNNMLCAGDTRSGGNQDLHDACQGDSGGPLVCMINKQMTLTGIISWGLGCGQKDVPGVYTKVTNYLDWIHDNMKQ
uniprot
proteins
ec_number
3.4.21.68
uniprot
proteins
function
FUNCTION: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P19637}.
uniprot
proteins
mass_dalton
63097
uniprot
proteins
post_translational_modification
PTM: The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-308 catalyzed by plasmin, tissue kallikrein or factor Xa.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
2826484
uniprot
proteins
pubmed
7523120
uniprot
proteins
sequence_length
559
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space.
uniprot
proteins