IRAK1BP1
entrez
134728
canonical
uniprot
Q5VVH5
canonical
ensembl
ENSG00000146243
resolver
ensp
ENSP00000358956
resolver
ensp
ENSP00000475503
resolver
ensp
ENSP00000773006
resolver
ensp
ENSP00000798506
resolver
enst
ENST00000369940
resolver
genesymbol
IRAK1BP1
resolver
hgnc
HGNC:17368
resolver
uniprot_entry
IKBP1_HUMAN
resolver
amino_acid_sequence
MSLQKTPPTRVFVELVPWADRSRENNLASGRETLPGLRHPLSSTQAQTATREVQVSGTSEVSAGPDRAQVVVRVSSTKEAAAEAKKSVCRRLDYITQSLQQQGVQAENITVTKDFRRVENAYHMEAEVCITFTEFGKMQNICNFLVEKLDSSVVISPPQFYHTPGSVENLRRQACLVAVENAWRKAQEVCNLVGQTLGKPLLIKEEETKEWEGQIDDHQSSRLSSSLTVQQKIKSATIHAASKVFITFEVKGKEKRKKHL
uniprot
proteins
function
FUNCTION: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
29106
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-56 and/or Ser-62 is required for full activity. Phosphorylated on at least one of Ser-235, Thr-237, Ser-242 and Thr-247 upon TNF activation, which favors nuclear translocation (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
IRAK1BP1 family
uniprot
proteins
pubmed
11096118
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins