TM7SF2
entrez
7108
canonical
uniprot
O76062
canonical
ensembl
ENSG00000149809
resolver
ensp
ENSP00000279263
resolver
ensp
ENSP00000329520
resolver
genesymbol
TM7SF2
resolver
genesymbol_syn
ANG1
resolver
hgnc
HGNC:11863
resolver
uniprot
A8K4H0
resolver
uniprot
O95982
resolver
uniprot
Q8IY06
resolver
uniprot
Q96E64
resolver
uniprot
Q96GZ1
resolver
uniprot_entry
ERG24_HUMAN
resolver
uniprot_sec
A8K4H0
resolver
uniprot_sec
O95982
resolver
uniprot_sec
Q8IY06
resolver
uniprot_sec
Q96E64
resolver
uniprot_sec
Q96GZ1
resolver
amino_acid_sequence
MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY
uniprot
proteins
ec_number
1.3.1.70
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. {ECO:0000269|PubMed:16784888}.
uniprot
proteins
mass_dalton
46406
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; cholesterol biosynthesis.
uniprot
proteins
protein_family
ERG4/ERG24 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16784888
uniprot
proteins
pubmed
27336722
uniprot
proteins
pubmed
9615229
uniprot
proteins
pubmed
9878250
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:Q71KT5}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:9878250}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..35; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..81; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 102..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 129..148; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 255..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 287..304; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 355..377; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins