Slc3a1
entrez
29484
canonical
uniprot
Q64319
canonical
ensembl
ENSRNOG00000007006
resolver
ensembl
ENSRNOG00055019152
resolver
ensembl
ENSRNOG00060004289
resolver
ensembl
ENSRNOG00065007957
resolver
ensp
ENSRNOP00000009581
resolver
ensp
ENSRNOP00055026470
resolver
ensp
ENSRNOP00060005457
resolver
ensp
ENSRNOP00065009246
resolver
enst
ENSRNOT00000009581
resolver
enst
ENSRNOT00055032680
resolver
enst
ENSRNOT00060007198
resolver
enst
ENSRNOT00065012552
resolver
genesymbol
Slc3a1
resolver
genesymbol_syn
Nbat
resolver
uniprot
Q62672
resolver
uniprot_entry
SLC31_RAT
resolver
uniprot_sec
Q62672
resolver
amino_acid_sequence
MNEDKDKRDSIQMSMKGCRTNNGFVQNEDIQEQDPDSRDTPQSNAVSIPAPEEPQLKVVRPYAGMPKEVLFQFSGQARYRVPREILFWLTVVSVFLLIGATIAIIIISPKCLDWWQAGPMYQIYPRSFKDSDKDGNGDLKGIQEKLDYITALNIKTIWITSFYKSPLKDFRYAVEDFKEIDPIFGTMKDFENLVAAVHDKGLKLIIDFIPNHTSDKHPWFQSSRTRSGKYTDYYIWHNCTHANGVTTPPNNWLSVYGNSSWQFDEERKQCYFHQFLKEQPDLNFRNPAVQEEIKEIIKFWLSKGVDGFSFDAVKFLLEAKDLRNEIQVNTSQIPDTVTRYSELYHDFTTTQVGMHDLVRDFRQTMNQFSREPGRYRFMGTEVSAESTERTMVYYGLSFIQEADFPFNKYLATLDTLSGHTVYEAITSWMENMPEGKWPNWMIGGPETSRLTSRVGSEYVNAMNMLLFTLPGTPITYYGEEIGMGDISITNLNERYDTNALLSKSPMQWDNSSNAGFTEANHTWLPTNSDYHTVNVDVQKTQPSSALRLYQDLSLLHARELLLSRGWFCLLRDDNHSVVYTRELDGIDKVFLVVLNFGESSTVLNLQETISDVPTKLRIRLSTNPASKGSDVDTHAVSLEKGEGLILEHSMKTLLHHQKAFRDKCFISNRACYSSVLDLLYSSC
uniprot
proteins
function
FUNCTION: Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heteromers to the plasma membrane (By similarity) (PubMed:1376924, PubMed:1729674). Associates with SLC7A9 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1. SLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine. SLC7A9-SLC3A1 acts as a major transporter for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in early proximal tubules (By similarity) (PubMed:1376924, PubMed:1729674). Associates with SLC7A13 to form a functional complex that transports anionic and neutral amino acids via exchange or facilitated diffusion. SLC7A13-SLC3A1 may act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate (By similarity). {ECO:0000250|UniProtKB:Q07837, ECO:0000250|UniProtKB:Q91WV7, ECO:0000269|PubMed:1376924, ECO:0000269|PubMed:1729674}.
uniprot
proteins
mass_dalton
78507
uniprot
proteins
pubmed
10506124
uniprot
proteins
pubmed
1376924
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1729674
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8052618
uniprot
proteins
sequence_length
683
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q91WV7}; Single-pass type II membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q91WV7}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 87..107; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins