Kbtbd8
entrez
500262
canonical
uniprot
B1H285
canonical
ensembl
ENSRNOG00000013390
resolver
ensp
ENSRNOP00000017889
resolver
enst
ENSRNOT00000017889
resolver
genesymbol
Kbtbd8
resolver
uniprot
F8WFZ9
resolver
uniprot_entry
F8WFZ9_RAT
resolver
uniprot_entry
KBTB8_RAT
resolver
amino_acid_sequence
MDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDAFIEKIPPRFAQAIVKSCGEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWMTVCAMPVAMEFHNAVEHKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRVFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRATQVTVEEHIFRTSRKNSLYQYDDIADQWMKVYETPDRLWDLGRHFECAVAKLYPQCLQKVL
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. {ECO:0000250|UniProtKB:Q8NFY9}.
uniprot
proteins
mass_dalton
66322
uniprot
proteins
protein_family
KBTBD8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
575
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8NFY9}. Golgi apparatus {ECO:0000250|UniProtKB:Q8NFY9}. Note=Translocates to the spindle apparatus during mitosis. {ECO:0000250|UniProtKB:Q8NFY9}.
uniprot
proteins