Q8VHK6
uniprot
Q8VHK6
canonical
amino_acid_sequence
MALMAVNTRCLCLFLLCTITGHSLEIKVNPPQDFEILDPGLLGYLYLQWKPPVVMDNFKECKLEYELKYRNVDSDSWKTIITRNLIYKDGFDLNKGIEGKIRTHLSEHCTNGSEVQSPWTEASYGIADEGSLGTKIQDMKCIYYNWQYLVCSWKPGKTVHSDTNYTMFFWYEGLDHALQCADYLQDNEKNVGCKLSNLDSSDYKDFFIRVNGSSKLEPIRSSYMVFQLQNIVKPLPPEFLHISVENSIDIRMKWSTPGGPIPPSCYTYEIVVREDDISWESATDKNDMKLKRRANESEDLCFFVRCKINIYCADDGIWSEWSEEECWEGYTGPDSKIVFIVPVCLFFIFLLLLLCLIVEKEDPEPTLSLHVDLNKEMYAYEETLC
uniprot
proteins
function
FUNCTION: Cell surface receptor that plays a role in the regulation of IL-13-mediated responses. Functions as a decoy receptor that inhibits IL-13- and IL-4-mediated signal transduction via the JAK-STAT pathway and thereby modulates immune responses and inflammation. Serves as a functional signaling receptor for IL-13 in an alternative pathway involving AP-1 ultimately leading to the production of TGFB1. {ECO:0000250|UniProtKB:Q14627}.
uniprot
proteins
mass_dalton
44622
uniprot
proteins
post_translational_modification
PTM: Cleaved by MMP8 leading to a soluble form that is also able to interact with IL13. {ECO:0000250|UniProtKB:Q14627}.
uniprot
proteins
protein_family
Type 5 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
12241113
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q14627}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q14627}.
uniprot
proteins
transmembrane_region
TRANSMEM 337..357; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins