Dgke
entrez
56077
canonical
uniprot
Q9R1C6
canonical
ensembl
ENSMUSG00000000276
resolver
ensp
ENSMUSP00000000285
resolver
ensp
ENSMUSP00000103526
resolver
ensp
ENSMUSP00000318026
resolver
ensp
ENSMUSP00000326420
resolver
ensp
ENSMUSP00000326421
resolver
enst
ENSMUST00000000285
resolver
enst
ENSMUST00000107894
resolver
genesymbol
Dgke
resolver
uniprot
Q5SU69
resolver
uniprot_entry
DGKE_MOUSE
resolver
uniprot_sec
Q5SU69
resolver
amino_acid_sequence
MEGDQRSGPPAQSLLPDGHLVLWTLCSVLLPVFITLWCSLQRSRRQLHRRDIFRKSKHCWRDTDLFSHPTYCCVCAQHILQGAFCDCCGLRVDEGCLKKVDKRFPCKEIMLKNDKAADAMPHHWIRGNVPLCSYCVFCRQQCGSQPKLCDYRCIWCQKTVHDECMRGSLRSEKCDFGEFRNLIIPPSYLTSINQMRKDKNTNYEGLASKFGKQWTPLIILANSRSGTNMGEGLLGEFKILLNPVQVFDVTKTPPIKALQLCTLLPYYSVRVLVCGGDGTVGWVLDAIDEMKIKGQEKYIPEVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKIELELDGERVELPNLEGIIVLNIGYWGGGCRLWEGMGDETYPLARHDDGLLEIVGVYGSFHCAQIQVKLANPFRIGQAHTVRLTLKCSMMPMQVDGEPWAQGPCTVTITHKTHALMLYFSGEQSDDDISSPSDHEDVKEAE
uniprot
proteins
ec_number
2.7.1.107
uniprot
proteins
function
FUNCTION: Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11287665). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11287665). Also plays an important role in the biosynthesis of complex lipids (By similarity). Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle (PubMed:11287665, PubMed:19744926). Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently (By similarity). {ECO:0000250|UniProtKB:P52429, ECO:0000269|PubMed:11287665, ECO:0000269|PubMed:19744926}.
uniprot
proteins
mass_dalton
63635
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000269|PubMed:11287665, ECO:0000269|PubMed:19744926}.
uniprot
proteins
protein_family
Eukaryotic diacylglycerol kinase family
uniprot
proteins
pubmed
11287665
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19744926
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23542698
uniprot
proteins
sequence_length
564
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P52429}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P52429}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins