QPRT
entrez
23475
canonical
uniprot
Q15274
canonical
ensembl
ENSG00000103485
resolver
ensp
ENSP00000378782
resolver
ensp
ENSP00000404873
resolver
ensp
ENSP00000455183
resolver
ensp
ENSP00000577320
resolver
enst
ENST00000395384
resolver
enst
ENST00000449759
resolver
enst
ENST00000562473
resolver
genesymbol
HEL-S-90n
resolver
genesymbol
QPRT
resolver
genesymbol_syn
QPRT
resolver
hgnc
HGNC:9755
resolver
uniprot
B4DDH4
resolver
uniprot
H3BP73
resolver
uniprot
Q53XW7
resolver
uniprot
Q96G22
resolver
uniprot
Q9BSG6
resolver
uniprot
V9HWJ5
resolver
uniprot_entry
B4DDH4_HUMAN
resolver
uniprot_entry
H3BP73_HUMAN
resolver
uniprot_entry
NADC_HUMAN
resolver
uniprot_entry
V9HWJ5_HUMAN
resolver
uniprot_sec
Q53XW7
resolver
uniprot_sec
Q96G22
resolver
uniprot_sec
Q9BSG6
resolver
activity_regulation
ACTIVITY REGULATION: Activity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a competitive and a non-competitive manner (PubMed:17868694). Competitively inhibited by phthalic acid (PHT) (PubMed:24038671). {ECO:0000269|PubMed:17868694, ECO:0000269|PubMed:24038671}.
uniprot
proteins
amino_acid_sequence
MDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFTLKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH
uniprot
proteins
ec_number
2.4.2.19
uniprot
proteins
function
FUNCTION: Involved in the catabolism of quinolinic acid (QA). {ECO:0000269|PubMed:17868694, ECO:0000269|PubMed:24038671, ECO:0000269|PubMed:9473669}.
uniprot
proteins
mass_dalton
30846
uniprot
proteins
mutagenesis
MUTAGEN 1..12; /note="Missing: Forms dimers instead of hexamers."; /evidence="ECO:0000269|PubMed:26805589"; MUTAGEN 1..10; /note="Missing: Forms dimers instead of hexamers."; /evidence="ECO:0000269|PubMed:26805589"; MUTAGEN 1..9; /note="Missing: Forms dimers instead of hexamers."; /evidence="ECO:0000269|PubMed:26805589"; MUTAGEN 1..8; /note="Missing: Forms dimers instead of hexamers."; /evidence="ECO:0000269|PubMed:26805589"; MUTAGEN 1..4; /note="Missing: No effect on hexamer formation."; /evidence="ECO:0000269|PubMed:26805589"; MUTAGEN 102; /note="R->A,Q: Reduced activity."; /evidence="ECO:0000269|PubMed:17868694"; MUTAGEN 138; /note="R->Q: Loss of activity."; /evidence="ECO:0000269|PubMed:17868694"; MUTAGEN 139; /note="K->A,S: Loss of activity."; /evidence="ECO:0000269|PubMed:17868694"; MUTAGEN 161; /note="R->A: Reduced activity."; /evidence="ECO:0000269|PubMed:17868694"; MUTAGEN 161; /note="R->Q: Loss of activity."; /evidence="ECO:0000269|PubMed:17868694"; MUTAGEN 171; /note="K->A,S: Loss of activity."; /evidence="ECO:0000269|PubMed:17868694
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1. {ECO:0000269|PubMed:17868694, ECO:0000269|PubMed:24038671, ECO:0000269|PubMed:9473669}.
uniprot
proteins
protein_family
NadC/ModD family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17868694
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24038671
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26805589
uniprot
proteins
pubmed
9473669
uniprot
proteins
sequence_length
297
uniprot
proteins