CWF19L2
entrez
143884
canonical
uniprot
Q2TBE0
canonical
ensembl
ENSG00000152404
resolver
ensp
ENSP00000282251
resolver
ensp
ENSP00000755602
resolver
genesymbol
CWF19L2
resolver
hgnc
HGNC:26508
resolver
uniprot
A4FU66
resolver
uniprot
A4FU67
resolver
uniprot
A4FU68
resolver
uniprot
A8KAD6
resolver
uniprot
Q6PHW1
resolver
uniprot
Q96MI1
resolver
uniprot_entry
C19L2_HUMAN
resolver
uniprot_sec
A4FU66
resolver
uniprot_sec
A4FU67
resolver
uniprot_sec
A4FU68
resolver
uniprot_sec
A8KAD6
resolver
uniprot_sec
Q6PHW1
resolver
uniprot_sec
Q96MI1
resolver
amino_acid_sequence
MATSMAAASGRFESAKSIEERKEQTRNARAEVLRQAKANFEKEERRKELKRLRGEDTWMLPDVNERIEQFSQEHSVKKKKKKDKHSKKAKKEKKKKSKKQKYEKNNESSDSSSSSEDEWVEAVPSQTPDKEKAWKVKDEKSGKDDTQIIKRDEWMTVDFMSVKTVSSSSLKAEKETMRKIEQEKNQALEQSKLMERELNPYWKDGGTGLPPEDCSVSSITKVSVVEDGGLSWLRKSYLRMKEQAEKQSRNFEDIVAERYGSMEIFQSKLEDAEKAASTKEDYRRERWRKPTYSDKAQNCQESRESDLVKYGNSSRDRYATTDTAKNSNNEKFIGDEKDKRPGSLETCRRESNPRQNQEFSFGNLRAKFLRPSDDEELSFHSKGRKFEPLSSSSALVAQGSLCSGFRKPTKNSEERLTSWSRSDGRGDKKHSNQKPSETSTDEHQHVPEDPREKSQDEVLRDDPPKKEHLRDTKSTFAGSPERESIHILSVDEKNKLGAKIIKAEMMGNMELAEQLKVQLEKANKFKETITQIPKKSGVENEDQQEVILVRTDQSGRVWPVNTPGKSLESQGGRRKRQMVSTHEERERVRYFHDDDNLSLNDLVKNEKMGTAENQNKLFMRMASKFMGKTDGDYYTLDDMFVSKAAERERLGEEEENQRKKAIAEHRSLAAQMEKCLYCFDSSQFPKHLIVAIGVKVYLCLPNVRSLTEGHCLIVPLQHHRAATLLDEDIWEEIQMFRKSLVKMFEDKGLDCIFLETNMSMKKQYHMVYECIPLPKEVGDMAPIYFKKAIMESDEEWSMNKKLIDLSSKDIRKSVPRGLPYFSVDFGLHGGFAHVIEDQHKFPHYFGKEIIGGMLDIEPRLWRKGIRESFEDQRKKALQFAQWWKPYDFTKSKNY
uniprot
proteins
function
FUNCTION: RNA-binding protein which regulates alternative splicing (By similarity). Recognizes the 5'-GG[A/C][A/G]G[A/C/G]-3' motif with 58% of target sequences containing a 5'-GGCAGA-3' motif (By similarity). Directly binds and regulates the splicing of genes related to spermatogenesis such as ZNHIT1, BTRC and FBXW7 and is thus required for male fertility (By similarity). Also has an indirect effect on splicing by acting on the splicing factor RBFOX1 (By similarity). Required for spliceosome assembly and stability (By similarity). Required for debranching of intron-derived lariat RNAs (PubMed:41422678). {ECO:0000250|UniProtKB:Q8BG79, ECO:0000269|PubMed:41422678}.
uniprot
proteins
mass_dalton
103787
uniprot
proteins
protein_family
CWF19 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
41422678
uniprot
proteins
sequence_length
894
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:41422678}.
uniprot
proteins