Cyp39a1
entrez
56050
canonical
uniprot
Q9JKJ9
canonical
ensembl
ENSMUSG00000023963
resolver
ensp
ENSMUSP00000130073
resolver
ensp
ENSMUSP00000156567
resolver
ensp
ENSMUSP00000156870
resolver
enst
ENSMUST00000170988
resolver
enst
ENSMUST00000233437
resolver
enst
ENSMUST00000233627
resolver
genesymbol
Cyp39a1
resolver
uniprot
A0A3B2W4C8
resolver
uniprot
A0A3B2WCK5
resolver
uniprot
Q544S6
resolver
uniprot_entry
A0A3B2W4C8_MOUSE
resolver
uniprot_entry
A0A3B2WCK5_MOUSE
resolver
uniprot_entry
CP39A_MOUSE
resolver
uniprot_entry
Q544S6_MOUSE
resolver
amino_acid_sequence
MGIMELFSPIAIAVLGSCVLFLFSRLKNLLGPPCIQGWIPWIGAGLEFGKAPLEFIEKARIKYGPVFTIFAMGNRMTFVSEEEGINVLLKSEHVDFESAVQSPVYHTAWIPKNVFSALHERLYALMKGKMGTFNTHHFTGPLTEELHEQLEGLGTHGTMDLNDFVRYLLYPATLNTLFKKGLFLTDKRTIKEFYQQFKTYDEGFEYGSQLPEWLLRNWSKSKRWLLALFEKNIGNIKAHGSAGHSGTLLQAILEVVETETRQYSPNYGLVVLWAALANAPPIAFWTLGYILSHPDIHRTVLESISSVFGTAGKDKIKVSEDDLKKLLIIKWCILESVRLRAPGVITRKVVKPVKILNHTVPSGDLLMLSPFWLHRNPKYFPEPESFKPERWKEANLDKYIFLDYFMAFGGGKFQCPGRWFALLEIQLCIILVLYKYECSLLDPLPKQSSRHLVGVPQPAGKCRIEYKQRA
uniprot
proteins
ec_number
1.14.14.26
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver (PubMed:10748047). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10748047). {ECO:0000269|PubMed:10748047}.
uniprot
proteins
mass_dalton
53575
uniprot
proteins
pathway_participation
PATHWAY: Steroid metabolism; cholesterol degradation. {ECO:0000250|UniProtKB:Q9NYL5}.; PATHWAY: Lipid metabolism; bile acid biosynthesis. {ECO:0000250|UniProtKB:Q9NYL5}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10748047
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q64654}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:Q64654}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 3..23; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 270..290; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins