GNA13
entrez
10672
canonical
uniprot
Q14344
canonical
ensembl
ENSG00000120063
resolver
ensp
ENSP00000400717
resolver
ensp
ENSP00000439647
resolver
genesymbol
GNA13
resolver
hgnc
HGNC:4381
resolver
uniprot
B2R977
resolver
uniprot
B7Z7R0
resolver
uniprot
F5H1G8
resolver
uniprot
Q8TD70
resolver
uniprot_entry
GNA13_HUMAN
resolver
uniprot_sec
B2R977
resolver
uniprot_sec
B7Z7R0
resolver
uniprot_sec
F5H1G8
resolver
uniprot_sec
Q8TD70
resolver
amino_acid_sequence
MADFLPSRSVLSVCFPGCLLTSGEAEQQRKSKEIDKCLSREKTYVKRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKGMRVLVDAREKLHIPWGDNSNQQHGDKMMSFDTRAPMAAQGMVETRVFLQYLPAIRALWADSGIQNAYDRRREFQLGESVKYFLDNLDKLGEPDYIPSQQDILLARRPTKGIHEYDFEIKNVPFKMVDVGGQRSERKRWFECFDSVTSILFLVSSSEFDQVLMEDRLTNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLEEKVQIVSIKDYFLEFEGDPHCLRDVQKFLVECFRNKRRDQQQKPLYHHFTTAINTENIRLVFRDVKDTILHDNLKQLMLQ
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16705036, PubMed:16787920, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:12515866, PubMed:15240885). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16705036, PubMed:16787920, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in a process independent from Rho activation (PubMed:11976333). In lymphoid follicles, transmits P2RY8- and S1PR2-dependent signals that lead to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:P27601, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:12515866, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:16705036, ECO:0000269|PubMed:16787920, ECO:0000269|PubMed:25274307, ECO:0000269|PubMed:27084452}.
uniprot
proteins
mass_dalton
44050
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="C->S: Fails to localize to plasma membranes and failed to activate Rho-dependent serum response factor-mediated transcription and actin stress fiber formation."; /evidence="ECO:0000269|PubMed:10747909"; MUTAGEN 18; /note="C->S: Fails to localize to plasma membranes and failed to activate Rho-dependent serum response factor-mediated transcription and actin stress fiber formation."; /evidence="ECO:0000269|PubMed:10747909"; MUTAGEN 203; /note="T->A: Abolishes phosphorylation by PKA; disrupts heterotrimer stability."; /evidence="ECO:0000269|PubMed:12399457
uniprot
proteins
post_translational_modification
PTM: Palmitoylation is critical for proper membrane localization and signaling. {ECO:0000269|PubMed:10747909}.; PTM: Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation. {ECO:0000269|PubMed:12399457}.
uniprot
proteins
protein_family
G(12) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
pubmed
10026210
uniprot
proteins
pubmed
10747909
uniprot
proteins
pubmed
11094164
uniprot
proteins
pubmed
11976333
uniprot
proteins
pubmed
12399457
uniprot
proteins
pubmed
12515866
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15240885
uniprot
proteins
pubmed
15339924
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16202387
uniprot
proteins
pubmed
16705036
uniprot
proteins
pubmed
16787920
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
18703424
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23994616
uniprot
proteins
pubmed
25274307
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27084452
uniprot
proteins
pubmed
35418682
uniprot
proteins
pubmed
36543774
uniprot
proteins
pubmed
7791744
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10747909}; Peripheral membrane protein {ECO:0000269|PubMed:10747909}; Cytoplasmic side {ECO:0000269|PubMed:10747909}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasm {ECO:0000269|PubMed:18703424}. Nucleus {ECO:0000269|PubMed:18703424}. Note=Associated to the plasma membrane via lipid-anchor (PubMed:10747909). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages (PubMed:18703424). In round spermatids, also present in the nuclei (PubMed:18703424). {ECO:0000269|PubMed:10747909, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18703424}.
uniprot
proteins