Chga
entrez
12652
canonical
uniprot
P26339
canonical
ensembl
ENSMUSG00000021194
resolver
ensp
ENSMUSP00000021610
resolver
enst
ENSMUST00000021610
resolver
genesymbol
Chga
resolver
uniprot_entry
CMGA_MOUSE
resolver
amino_acid_sequence
MRSTAVLALLLCAGQVFALPVNSPMTKGDTKVMKCVLEVISDSLSKPSPMPVSPECLETLQGDERILSILRHQNLLKELQDLALQGAKERAQQPLKQQQPPKQQQQQQQQQQQEQQHSSFEDELSEVFENQSPDAKHRDAAAEVPSRDTMEKRKDSDKGQQDGFEATTEGPRPQAFPEPNQESPMMGDSESPGEDTATNTQSPTSLPSQEHVDPQATGDSERGLSAQQQARKAKQEEKEEEEEEEAVAREKAGPEEVPTAASSSHFHAGYKAIQKDDGQSDSQAVDGDGKTEASEALPSEGKGELEHSQQEEDGEEAMVGTPQGLFPQGGKGRELEHKQEEEEEEEERLSREWEDKRWSRMDQLAKELTAEKRLEGEDDPDRSMKLSFRTRAYGFRDPGPQLRRGWRPSSREDSVEARSDFEEKKEEEGSANRRAEDQELESLSAIEAELEKVAHQLQALRRG
uniprot
proteins
function
FUNCTION: [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines. {ECO:0000250|UniProtKB:P10645}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (PubMed:21436258). Pyroglutaminated (pGlu)-serpinin exerts an antiapoptotic effect on cells exposed to oxidative stress (PubMed:21537909). {ECO:0000269|PubMed:21436258, ECO:0000269|PubMed:21537909}.
uniprot
proteins
mass_dalton
51789
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains chondroitin sulfate (CS). CS attachment is pH-dependent, being observed at mildly acidic conditions of pH 5 but not at neutral pH, and promotes self-assembly in vitro. {ECO:0000250|UniProtKB:P10645}.
uniprot
proteins
protein_family
Chromogranin/secretogranin protein family
uniprot
proteins
pubmed
12388744
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2071596
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21436258
uniprot
proteins
pubmed
21537909
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:12388744}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle {ECO:0000250|UniProtKB:P10354}. Secreted {ECO:0000269|PubMed:12388744}. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions.; SUBCELLULAR LOCATION: [Serpinin]: Secreted {ECO:0000269|PubMed:21436258, ECO:0000269|PubMed:21537909}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:21537909}. Note=Pyroglutaminated serpinin localizes to secretory vesicle. {ECO:0000269|PubMed:21537909}.
uniprot
proteins