Chtop
entrez
66511
canonical
uniprot
Q9CY57
canonical
ensembl
ENSMUSG00000001017
resolver
ensp
ENSMUSP00000001043
resolver
ensp
ENSMUSP00000061800
resolver
ensp
ENSMUSP00000075936
resolver
ensp
ENSMUSP00000102965
resolver
ensp
ENSMUSP00000102966
resolver
ensp
ENSMUSP00000102967
resolver
ensp
ENSMUSP00000102969
resolver
enst
ENSMUST00000107346
resolver
genesymbol
Chtop
resolver
genesymbol_syn
2500003M10Rik
resolver
genesymbol_syn
Fop
resolver
uniprot
B7ZMS6
resolver
uniprot
E9PW20
resolver
uniprot
Q0VBG3
resolver
uniprot
Q3U7V6
resolver
uniprot
Q3UF43
resolver
uniprot
Q3V105
resolver
uniprot
Q5XJG9
resolver
uniprot
Q8C5N4
resolver
uniprot
Q9D7T3
resolver
uniprot
Q9DB03
resolver
uniprot
Q9DC54
resolver
uniprot
Q9JJ95
resolver
uniprot_entry
B7ZMS6_MOUSE
resolver
uniprot_entry
CHTOP_MOUSE
resolver
uniprot_entry
E9PW20_MOUSE
resolver
uniprot_sec
Q0VBG3
resolver
uniprot_sec
Q3U7V6
resolver
uniprot_sec
Q3UF43
resolver
uniprot_sec
Q3V105
resolver
uniprot_sec
Q5XJG9
resolver
uniprot_sec
Q8C5N4
resolver
uniprot_sec
Q9D7T3
resolver
uniprot_sec
Q9DB03
resolver
uniprot_sec
Q9DC54
resolver
uniprot_sec
Q9JJ95
resolver
amino_acid_sequence
MAAQSAPKVVLKSTTKMSLNERFTNMLKNKQPMPVNIRASMQQQQQLASARNRRLAQQMENRPSVQAALKLKQKSLKQRLGKSNIQARLGRPIGALARGAIGGRGLPIIQRGLPRGGLRGGRATRTLLRGGMSLRGQNLLRGGRAVAPRMGLRRGGVRGRGGPGRGGLGRGAMGRGGIGGRGRGMIGRGRGGFGGRGRGRGRGRGALTRPVLTKEQLDNQLDAYMSKTKGHLDAELDAYMAQTDPETND
uniprot
proteins
function
FUNCTION: Plays an important role in the ligand-dependent activation of estrogen receptor target genes (By similarity). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivates genes involved in glioblastomagenesis (PubMed:25284789). {ECO:0000250|UniProtKB:Q9Y3Y2, ECO:0000269|PubMed:20688955, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:25284789}.
uniprot
proteins
mass_dalton
26585
uniprot
proteins
post_translational_modification
PTM: Asymmetrically methylated by PRMT1. Symmetrically methylated by PRMT5. {ECO:0000269|PubMed:19858291}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19254951
uniprot
proteins
pubmed
19858291
uniprot
proteins
pubmed
20688955
uniprot
proteins
pubmed
22872859
uniprot
proteins
pubmed
25284789
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19254951}. Nucleus, nucleolus {ECO:0000269|PubMed:19254951}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19858291, ECO:0000269|PubMed:22872859}. Nucleus speckle {ECO:0000269|PubMed:19858291}. Note=Mostly associated with facultative heterochromatin. Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (By similarity). {ECO:0000250|UniProtKB:Q9Y3Y2, ECO:0000269|PubMed:19858291}.
uniprot
proteins