Dhh
entrez
13363
canonical
uniprot
Q61488
canonical
ensembl
ENSMUSG00000023000
resolver
ensp
ENSMUSP00000023737
resolver
enst
ENSMUST00000023737
resolver
genesymbol
Dhh
resolver
uniprot
Q544P6
resolver
uniprot_entry
DHH_MOUSE
resolver
uniprot_entry
Q544P6_MOUSE
resolver
amino_acid_sequence
MALPASLLPLCCLALLALSAQSCGPGRGPVGRRRYVRKQLVPLLYKQFVPSMPERTLGASGPAEGRVTRGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHIHVSVKADNSLAVRAGGCFPGNATVRLRSGERKGLRELHRGDWVLAADAAGRVVPTPVLLFLDRDLQRRASFVAVETERPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDALQPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELMG
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: [Desert hedgehog protein]: Precursor of desert hedgehog, a morphogen that activates the smoothened signaling pathway, and which is essential for a variety of patterning events during development (PubMed:40494346). The C-terminal part of the precursor displays an autoproteolysis and a cholesterol transferase activity, resulting (1) in the cleavage of the full-length protein into two parts, desert hedgehog protein N-product and C-product and (2) covalent attachment of a cholesterol moiety to the C-terminus of the newly generated N-product (DHH-N) (By similarity). Both autoproteolysis and a cholesterol transferase activities occur in the endoplasmic reticulum (By similarity). Following additional lipidation, DHH-N acts as a morphogen, while the C-product is degraded in the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q62226, ECO:0000269|PubMed:40494346}.; FUNCTION: [Desert hedgehog protein N-product]: The dually lipidated desert hedgehog protein N-product is a morphogen that activates the smoothened signaling pathway, and which is essential for a variety of patterning events during development (PubMed:40494346). Acts by binding to the patched receptor (PTCH1 or PTCH2), relieving smoothened (SMO) inhibition by patched, activating the smoothened signaling pathway and transcription of target genes (PubMed:33063110, PubMed:40494346, PubMed:9811851). In the absence of DHH, patched represses the constitutive signaling activity of SMO (By similarity). DHH plays a key role in male gonad development (spermatogenesis) and the formation of Schwann cells (PubMed:10482238, PubMed:11090455, PubMed:8805249). Required for normal testis development and spermatogenesis, namely for the formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules (PubMed:11090455, PubMed:8805249). In Schwann cells, controls the development of the peripheral nerve sheath and the transition of mesenchymal cells to form the epithelium-like structure of the perineurial tube (PubMed:10482238). May induce motor neurons in lateral neural tube and may have a polarizing activity (By similarity). Involved in tissue regeneration: secreted from epithelial neuroendocrine cells and elicits a regenerative response from mesenchymal cells (PubMed:40494346). Functions in cell-cell mediated juxtacrine signaling (By similarity). Activates primary cilia signaling on neighboring valve interstitial cells through a paracrine mechanism (PubMed:32151560). Promotes endothelium integrity (PubMed:33063110). {ECO:0000250|UniProtKB:O43323, ECO:0000250|UniProtKB:Q15465, ECO:0000269|PubMed:10482238, ECO:0000269|PubMed:11090455, ECO:0000269|PubMed:32151560, ECO:0000269|PubMed:33063110, ECO:0000269|PubMed:40494346, ECO:0000269|PubMed:8805249, ECO:0000269|PubMed:9811851}.
uniprot
proteins
mass_dalton
43542
uniprot
proteins
post_translational_modification
PTM: [Desert hedgehog protein]: The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (DHH-N). DHH-N is the active species in both local and long-range signaling, whereas the C-product is degraded in the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:O43323, ECO:0000250|UniProtKB:Q62226}.; PTM: [Desert hedgehog protein N-product]: Dually lipidated: a cholesterol moiety is attached to its C-terminus following cleavage (By similarity). N-palmitoylated by HHAT following cholesterylation; palmitoylation is required for desert hedgehog protein N-product multimerization and full activity (By similarity). {ECO:0000250|UniProtKB:O43323, ECO:0000250|UniProtKB:Q62226}.
uniprot
proteins
protein_family
Hedgehog family
uniprot
proteins
pubmed
10482238
uniprot
proteins
pubmed
11090455
uniprot
proteins
pubmed
32151560
uniprot
proteins
pubmed
33063110
uniprot
proteins
pubmed
40494346
uniprot
proteins
pubmed
7720571
uniprot
proteins
pubmed
7916661
uniprot
proteins
pubmed
8805249
uniprot
proteins
pubmed
9811851
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Desert hedgehog protein]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15465}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q15465}. Note=Co-localizes with HHAT in the ER and Golgi membrane. {ECO:0000250|UniProtKB:Q15465}.; SUBCELLULAR LOCATION: [Desert hedgehog protein N-product]: Secreted {ECO:0000269|PubMed:33063110}. Cell membrane {ECO:0000250|UniProtKB:O43323}; Lipid-anchor {ECO:0000250|UniProtKB:Q62226}.
uniprot
proteins