Themis2
entrez
230787
canonical
uniprot
Q91YX0
canonical
ensembl
ENSMUSG00000037731
resolver
ensp
ENSMUSP00000036945
resolver
enst
ENSMUST00000045154
resolver
genesymbol
Themis2
resolver
genesymbol_syn
Icb1
resolver
uniprot
Q3U5K5
resolver
uniprot_entry
THMS2_MOUSE
resolver
uniprot_sec
Q3U5K5
resolver
amino_acid_sequence
MEPVPLQDFVSGLDPTSLPRVLRVCSGVYFEGSVYELFGNECCLSTGDLIKVTHVQLQKVVCEYPETGQTLELNPNFTGLFSPLTSLRSYRTLEDLVSAMPQNSTRWPIYFKSTQRIVTKASVVPEDQPLRLEAVEIHHGIRYARCVQVSKTKELLHLPLSQKGPFWRCKPSAPQTLHQILQDPALKDLTLSCPSLPWNSVILKPQYMLQAIMHMRSSIVKIPSTLEVEVEDVTASSQHIHFFKPLRLSEVLAGGGPFPLTTEILEVPEGPPVFLSPWVSFLRKGQRLCIYGPASPSWRVVASSKSRKVPRYFMLSGAYQGKLKRRPREFSTAYDLLGALQPGRPLRVVATKDCDGNEEENPDFSFLAVGDRLEVLRSGQVCGTKGQDIDVLVCQRLSEQSGEEEEDLEEIEDEAEDKEQILLPLYLSGSFVEEVNDSRRYNLVDLTAQYSLPCEVKVVTKDTRHPTDPLASFPGLRLEEKLTEPFLVVSLDSQPEMCFEIPPRWLDLTVVEAEGQPAQVARPLSIAPVEELSEAFYYSLRKLPASESQAPPPRPPKSQGINKKQQNIQSCKESSVKPQVVEPQKSCPQPQLKAKTLEALPKNKSNVYSKISVHKKDRKPNPQTQNSVLSMKPKTSSSLGKHSTMESHLLPDPDMDDHDYEEI
uniprot
proteins
function
FUNCTION: May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716). Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (PubMed:27992403). {ECO:0000269|PubMed:20644716, ECO:0000269|PubMed:27992403}.
uniprot
proteins
mass_dalton
74378
uniprot
proteins
mutagenesis
MUTAGEN 552; /note="P->A: Drastic decrease in GRB2-binding, but no effect on VAV-binding; when associated with A-555. Partial loss of enhancement of LPS-induced TNF production; when associated with A-555."; MUTAGEN 555; /note="P->A: Drastic decrease in GRB2-binding, but no effect on VAV-binding; when associated with A-552. Partial loss of enhancement of LPS-induced TNF production; when associated with A-552."; MUTAGEN 660; /note="Y->F: Loss of phosphorylation. Loss of LYN-binding. Slight decrease in GRB2-binding. No effect on VAV-binding. Partial loss of enhancement of LPS-induced TNF production."; /evidence="ECO:0000269|PubMed:20644716
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-660 is induced by LPS (PubMed:20644716). Phosphorylated by Src kinases (Lck or Fyn) following BCR engagement (PubMed:20644716). {ECO:0000269|PubMed:20644716}.
uniprot
proteins
protein_family
Themis family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19597497
uniprot
proteins
pubmed
19597499
uniprot
proteins
pubmed
20644716
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22732588
uniprot
proteins
pubmed
24907343
uniprot
proteins
pubmed
27992403
uniprot
proteins
sequence_length
663
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22732588}. Cytoplasm {ECO:0000269|PubMed:22732588}.
uniprot
proteins