Q9D7R2
uniprot
Q9D7R2
canonical
amino_acid_sequence
MSPARATAQRSLFPSMEITELEFVQIVVIVVVMMVMVVMITCLLSHYKLSARSFISRHSQARRRDDGLSSEGCLWPSESTVSGGMPEPQVYAPPRPTDRLAVPPFIQRSRFQPTYPYLQHEIALPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLIDSTMLGGPCPPSSNSGISATCYSSGGRMEGPPPTYSEVIGHYPGSSFQHQQSNGPSSLLEGTRLHHSHIAPLENKEKEKQKGHPL
uniprot
proteins
function
FUNCTION: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4. {ECO:0000269|PubMed:20129061}.
uniprot
proteins
mass_dalton
28716
uniprot
proteins
mutagenesis
MUTAGEN 139; /note="Y->A: Alters interaction with NEDD4."; /evidence="ECO:0000269|PubMed:11042109"; MUTAGEN 210; /note="Y->A: Abolishes interaction with NEDD4."; /evidence="ECO:0000269|PubMed:11042109
uniprot
proteins
protein_family
PMEPA1 family
uniprot
proteins
pubmed
11042109
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20129061
uniprot
proteins
pubmed
24627487
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..43; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins