SHISA7
entrez
729956
canonical
uniprot
A6NL88
canonical
ensembl
ENSG00000187902
resolver
ensp
ENSP00000365503
resolver
enst
ENST00000376325
resolver
genesymbol
SHISA7
resolver
hgnc
HGNC:35409
resolver
uniprot_entry
SHSA7_HUMAN
resolver
amino_acid_sequence
MPALLLLVLLASSAGQARARPSNATSAEPAGPLPALLAHLRRLTGALTGGGGAASPGANGTRTGPAGGAGAAARAPPPAELCHGYYDVMGQYDATFNCSTGSYRFCCGTCHYRFCCEHRHMRLAQASCSNYDTPRWATTPPPLAGGAGGAGGAGGGPGPGQAGWLEGGRTGGAGGRGGEGPGGSTAYVVCGVISFALAVGVGAKVAFSKASRAPRAHRDINVPRALVDILRHQAGPGTRPDRARSSSLTPGIGGPDSMPPRTPKNLYNTVKTPNLDWRALPPPSPSLHYSTLSCSRSFHNLSHLPPSYEAAVKSELNRYSSLKRLAEKDLDEAYLKRRPLELPRGTLPLHALRRPGTGGGYRMEAWGGPEELGLAPAPNPRRVMSQEHLLGDGGRSRYEFTLPRARLVSQEHLLLSSPEALRQSREHLLSPPRSPALPPDPTARASLAASHSNLLLGPGGPPTPLRGLPPPSSLHAHHHHALHGSPQPAWMSDAGGGGGTLARRPPFQRQGTLEQLQFIPGHHLPQHLRTASKNEVTV
uniprot
proteins
function
FUNCTION: Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall. May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses. {ECO:0000250|UniProtKB:Q8C3Q5}.
uniprot
proteins
mass_dalton
56214
uniprot
proteins
protein_family
Shisa family
uniprot
proteins
pubmed
15057824
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic density membrane {ECO:0000250|UniProtKB:Q8C3Q5}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8C3Q5}. Note=Localizes at GABAergic inhibitory synapses and colocalizes with gephyrin in hippocampal neurons. {ECO:0000250|UniProtKB:Q8C3Q5}.
uniprot
proteins
transmembrane_region
TRANSMEM 187..207; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins