Anpep
entrez
16790
canonical
uniprot
P97449
canonical
ensembl
ENSMUSG00000039062
resolver
ensp
ENSMUSP00000035943
resolver
ensp
ENSMUSP00000103015
resolver
enst
ENSMUST00000049004
resolver
enst
ENSMUST00000107392
resolver
genesymbol
Anpep
resolver
genesymbol_syn
Lap-1
resolver
genesymbol_syn
Lap1
resolver
uniprot
Q91YH8
resolver
uniprot
Q99K63
resolver
uniprot_entry
AMPN_MOUSE
resolver
uniprot_sec
Q91YH8
resolver
uniprot_sec
Q99K63
resolver
amino_acid_sequence
MAKGFYISKTLGILGILLGVAAVCTIIALSVVYAQEKNRNAENSATAPTLPGSTSATTATTTPAVDESKPWNQYRLPKTLIPDSYRVILRPYLTPNNQGLYIFQGNSTVRFTCNQTTDVIIIHSKKLNYTLKGNHRVVLRTLDGTPAPNIDKTELVERTEYLVVHLQGSLVEGRQYEMDSQFQGELADDLAGFYRSEYMEGDVKKVVATTQMQAADARKSFPCFDEPAMKAMFNITLIYPNNLIALSNMLPKESKPYPEDPSCTMTEFHSTPKMSTYLLAYIVSEFKNISSVSANGVQIGIWARPSAIDEGQGDYALNVTGPILNFFAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRESSLVFDSQSSSISNKERVVTVIAHELAHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSSPADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDLFKKGLSSYLHTYQYSNTVYLDLWEHLQKAVNQQTAVQPPATVRTIMDRWILQMGFPVITVNTNTGEISQKHFLLDSKSNVTRPSEFNYIWIAPIPFLKSGQEDHYWLDVEKNQSAKFQTSSNEWILLNINVTGYYLVNYDENNWKKLQNQLQTDLSVIPVINRAQIIHDSFNLASAKMIPITLALDNTLFLVKEAEYMPWQAALSSLNYFTLMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNNWVNRPPTLMEQYNEINAISTACSSGLKECRDLVVELYSQWMKNPNNNTIHPNLRSTVYCNAIAFGGEEEWNFAWEQFRNATLVNEADKLRSALACSKDVWILNRYLSYTLNPDYIRKQDTTSTIISIASNVAGHPLVWDFVRSNWKKLFENYGGGSFSFANLIQGVTRRFSSEFELQQLEQFKADNSATGFGTGTRALEQALEKTRANIDWVKENKDAVFKWFTENSS
uniprot
proteins
ec_number
3.4.11.2
uniprot
proteins
function
FUNCTION: Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines (By similarity). May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells (PubMed:8691132). May have a role in angiogenesis and promote cholesterol crystallization (By similarity). May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (PubMed:22677001). {ECO:0000250|UniProtKB:P15144, ECO:0000269|PubMed:22677001, ECO:0000269|PubMed:8691132}.
uniprot
proteins
mass_dalton
109651
uniprot
proteins
mutagenesis
MUTAGEN 354; /note="E->A: Reduces substrate affinity of SLC6A19-mediated amino acid transport."; /evidence="ECO:0000269|PubMed:22677001"; MUTAGEN 388; /note="E->A: No impact on substrate affinity of SLC6A19-mediated amino acid transport."; /evidence="ECO:0000269|PubMed:22677001"; MUTAGEN 410; /note="E->A: Reduces substrate affinity of SLC6A19-mediated amino acid transport."; /evidence="ECO:0000269|PubMed:22677001"; MUTAGEN 476; /note="Y->F: No impact on substrate affinity of SLC6A19-mediated amino acid transport."; /evidence="ECO:0000269|PubMed:22677001
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated. {ECO:0000269|PubMed:8805662}.; PTM: Sulfated. {ECO:0000250|UniProtKB:P15145}.; PTM: May undergo proteolysis and give rise to a soluble form. {ECO:0000250|UniProtKB:P15144}.
uniprot
proteins
protein_family
Peptidase M1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22677001
uniprot
proteins
pubmed
8103749
uniprot
proteins
pubmed
8691132
uniprot
proteins
pubmed
8805662
uniprot
proteins
sequence_length
966
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8805662}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P15144}. Note=Also found as a soluble form. {ECO:0000250|UniProtKB:P15144}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..32; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins