Enpep
entrez
64017
canonical
uniprot
P50123
canonical
ensembl
ENSRNOG00000051854
resolver
ensp
ENSRNOP00000068728
resolver
genesymbol
Enpep
resolver
uniprot
Q64200
resolver
uniprot
Q9JLQ7
resolver
uniprot
Q9JLQ9
resolver
uniprot
Q9QV24
resolver
uniprot_entry
AMPE_RAT
resolver
uniprot_sec
Q64200
resolver
uniprot_sec
Q9JLQ7
resolver
uniprot_sec
Q9JLQ9
resolver
uniprot_sec
Q9QV24
resolver
activity_regulation
ACTIVITY REGULATION: Substrate specificity is modulated by calcium which enhances the enzymatic activity for cleavage of acidic residues while reducing its activity with basic residues. Inhibited by aminopeptidase inhibitors amastatin and bestatin. {ECO:0000250|UniProtKB:Q07075}.
uniprot
proteins
amino_acid_sequence
MNFAEEEPSKKYCIKGKHVAIICATVVAVGLIVGLSVGLTRSCEPGTTPAPSNPPPHTSTALPPQDQNVCPDSDDESGEWKNFRLPDFIQPVHYDLEVKVLMEEDRYTGIVSISVNLSKDTRDLWLHIRETRITKLPELRRPSGEQVPIRRCFEYKKQEYVVIQAEEDLAATSGDSVYRLTIEFEGWLNGSLVGFYRTTYTEDGQTKSIAATDHEPTDARKSFPCFDEPNKKATYNISLIHPKEYSALSNMPVEKKETLDNDWKKTTFMKSVPMSTYLVCFAVHQFTSIQRTSRSGKPLTVYVQPNQKQTAEYAANITKAVFDFFEDYFAMEYSLPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLLSASSNQQRVASVVAHELVHQWFGNIVTMDWWDDLWLNEGFASFFEFLGVNHAEADWQMLSQVLLEDVLPVQEDDSLMSSHPVVVTVSTPAEITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYLENFKFKNAKTSDFWDSLEKASNQPVKEVMDTWTSQMGYPVVTVSGKQNVTQKRFLLDYKADPSQPPSALGYTWNIPIKWTENGNSNITVYYRSNREGITLNANLSGDGFLKINPDHIGFYRVNYEAETWDWIAETLSSNHMNFSSADRSSFIDDAFALARAQLLDYEKALNLTRYLTSEKDFLPWERVISAVSYIISMFEDDRELYPLIETYFRSQVKPIADSLGWQDTGSHITKLLRASVLGFACKMGAGEALGNASQLFEAWLKGNESIPVNLRLLVYRYGMQNSGNEAAWNYTLEQYQKTSLAQEKEKLLYGLASVKDVTLLARYLEMLKDPNIIKTQDVFTVIRYISYNSYGKSMAWNWIQLNWDYLVNRFTINDRYLGRIVTIAEPFNTELQLWQMQSFFAKYPNAGAGAKPREQVLETVKNNIEWLKLNRKSISEWFTSMP
uniprot
proteins
ec_number
3.4.11.7
uniprot
proteins
function
FUNCTION: Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. {ECO:0000250|UniProtKB:Q07075}.
uniprot
proteins
mass_dalton
107995
uniprot
proteins
protein_family
Peptidase M1 family
uniprot
proteins
pubmed
10666143
uniprot
proteins
pubmed
10978538
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7943354
uniprot
proteins
pubmed
8613196
uniprot
proteins
sequence_length
945
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q07075}; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins