Nlgn1
entrez
116647
canonical
uniprot
Q62765
canonical
ensembl
ENSRNOG00000032576
resolver
ensembl
ENSRNOG00055009326
resolver
ensembl
ENSRNOG00060002354
resolver
ensembl
ENSRNOG00065023630
resolver
ensp
ENSRNOP00000094652
resolver
ensp
ENSRNOP00000099159
resolver
ensp
ENSRNOP00000103300
resolver
enst
ENSRNOT00000107850
resolver
enst
ENSRNOT00000142652
resolver
genesymbol
Nlgn1
resolver
uniprot
A0A8I6GKV2
resolver
uniprot
A0ABK0LD52
resolver
uniprot_entry
A0A8I6GKV2_RAT
resolver
uniprot_entry
A0ABK0LD52_RAT
resolver
uniprot_entry
NLGN1_RAT
resolver
amino_acid_sequence
MALPRCMWPNYVWRAMMACVVHRGSGAPLTLCLLGCLLQTFHVLSQKLDDVDPLVTTNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRISKECARKPGKKICRKGDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARILATKVGCNVSDTVELVECLQKKPYKELVDQDVQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGVSASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITLRPTRKNSTPVTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAPEEEIMSLQMKHTDLDHECESIHPHEVVLRTACPPDYTLAMRRSPDDVPLMTPNTITMIPNTIPGIQPLHTFNTFTGGQNNTLPHPHPHPHSHSTTRV
uniprot
proteins
function
FUNCTION: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (By similarity). The protein is involved in nervous system development. {ECO:0000250|UniProtKB:Q99K10, ECO:0000269|PubMed:15620359, ECO:0000269|PubMed:9325340}.
uniprot
proteins
mass_dalton
94294
uniprot
proteins
mutagenesis
MUTAGEN 109; /note="N->A: N-glycosylation, localization to synapses, dendrites, and the cell membrane, as well as availability for trans-synaptic adhesion, are all impaired; when associated with A-303; A-343 and A-547."; /evidence="ECO:0000269|PubMed:37865312"; MUTAGEN 303; /note="N->A: N-glycosylation, localization to synapses, dendrites, and the cell membrane, as well as availability for trans-synaptic adhesion, are all impaired; when associated with A-109; A-343 and A-547."; /evidence="ECO:0000269|PubMed:37865312"; MUTAGEN 343; /note="N->A: N-glycosylation, localization to synapses, dendrites, and the cell membrane, as well as availability for trans-synaptic adhesion, are all impaired; when associated with A-109; A-303 and A-547."; /evidence="ECO:0000269|PubMed:37865312"; MUTAGEN 547; /note="N->A: N-glycosylation, localization to synapses, dendrites, and the cell membrane, as well as availability for trans-synaptic adhesion, are all impaired; when associated with A-109; A-303 and A-343."; /evidence="ECO:0000269|PubMed:37865312
uniprot
proteins
post_translational_modification
PTM: N-glycosylated, contains high-mannose, hybrid, complex and sialylated N-glycans. N-glycosylation is essential for localization to synapses, dendrites, and the cell membrane, and enhances its availability for trans-synaptic adhesion. O-glycosylated. {ECO:0000269|PubMed:37865312}.; PTM: The N-terminus is blocked.
uniprot
proteins
protein_family
Type-B carboxylesterase/lipase family
uniprot
proteins
pubmed
11329178
uniprot
proteins
pubmed
14769026
uniprot
proteins
pubmed
15458844
uniprot
proteins
pubmed
15620359
uniprot
proteins
pubmed
18093522
uniprot
proteins
pubmed
18334216
uniprot
proteins
pubmed
18434543
uniprot
proteins
pubmed
18755801
uniprot
proteins
pubmed
19914352
uniprot
proteins
pubmed
20624592
uniprot
proteins
pubmed
37865312
uniprot
proteins
pubmed
7736595
uniprot
proteins
pubmed
8576240
uniprot
proteins
pubmed
9325340
uniprot
proteins
pubmed
9694864
uniprot
proteins
pubmed
9927700
uniprot
proteins
sequence_length
843
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37865312}; Single-pass type I membrane protein {ECO:0000255}. Postsynaptic density {ECO:0000269|PubMed:18434543, ECO:0000269|PubMed:19914352, ECO:0000269|PubMed:9927700}. Synaptic cleft {ECO:0000269|PubMed:9927700}. Synaptic cell membrane {ECO:0000269|PubMed:9927700}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:37865312}. Synapse {ECO:0000269|PubMed:37865312}. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1. Localizes to dendritic membrane. {ECO:0000269|PubMed:19914352, ECO:0000269|PubMed:37865312, ECO:0000269|PubMed:9927700}.
uniprot
proteins
transmembrane_region
TRANSMEM 698..718; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins