NLRX1
entrez
79671
canonical
uniprot
Q86UT6
canonical
ensembl
ENSG00000160703
resolver
ensp
ENSP00000292199
resolver
ensp
ENSP00000386851
resolver
ensp
ENSP00000387334
resolver
ensp
ENSP00000433442
resolver
ensp
ENSP00000516517
resolver
ensp
ENSP00000516518
resolver
ensp
ENSP00000516519
resolver
ensp
ENSP00000635010
resolver
ensp
ENSP00000782438
resolver
enst
ENST00000474751
resolver
enst
ENST00000706728
resolver
genesymbol
NLRX1
resolver
genesymbol_syn
NOD5
resolver
genesymbol_syn
NOD9
resolver
hgnc
HGNC:29890
resolver
uniprot
A0A9L9PX86
resolver
uniprot
A8K6Q1
resolver
uniprot
B3KPK2
resolver
uniprot
B3KTA2
resolver
uniprot
Q7RTR3
resolver
uniprot
Q96D51
resolver
uniprot
Q9H724
resolver
uniprot_entry
A0A9L9PX86_HUMAN
resolver
uniprot_entry
NLRX1_HUMAN
resolver
uniprot_sec
A8K6Q1
resolver
uniprot_sec
B3KPK2
resolver
uniprot_sec
B3KTA2
resolver
uniprot_sec
Q7RTR3
resolver
uniprot_sec
Q96D51
resolver
uniprot_sec
Q9H724
resolver
amino_acid_sequence
MRWGHHLPRASWGSGFRRALQRPDDRIPFLIHWSWPLQGERPFGPPRAFIRHHGSSVDSAPPPGRHGRLFPSASATEAIQRHRRNLAEWFSRLPREERQFGPTFALDTVHVDPVIRESTPDELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVLGIMAKLLPLRALPLLFNLIKVVPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHPDEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVLRDLGGAAEGGARVVVSLTEGTAVSEYWSVILSEVQRNLNSWDRARVQRHLELLLRDLEDSRGATLNPWRKAQLLRVEGEVRALLEQLGSSGS
uniprot
proteins
function
FUNCTION: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (By similarity). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity). {ECO:0000250|UniProtKB:Q3TL44, ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:27393910}.
uniprot
proteins
mass_dalton
107616
uniprot
proteins
protein_family
NLRP family
uniprot
proteins
pubmed
12766759
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15771576
uniprot
proteins
pubmed
15952891
uniprot
proteins
pubmed
18200010
uniprot
proteins
pubmed
18219313
uniprot
proteins
pubmed
22386589
uniprot
proteins
pubmed
22749352
uniprot
proteins
pubmed
24799673
uniprot
proteins
pubmed
27393910
uniprot
proteins
sequence_length
975
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18200010, ECO:0000269|PubMed:18219313, ECO:0000269|PubMed:27393910}.
uniprot
proteins