Slc7a11
entrez
26570
canonical
uniprot
Q9WTR6
canonical
ensembl
ENSMUSG00000027737
resolver
ensp
ENSMUSP00000029297
resolver
ensp
ENSMUSP00000258580
resolver
enst
ENSMUST00000029297
resolver
genesymbol
Slc7a11
resolver
genesymbol_syn
sut
resolver
uniprot
Q542C8
resolver
uniprot_entry
Q542C8_MOUSE
resolver
uniprot_entry
XCT_MOUSE
resolver
amino_acid_sequence
MVRKPVVATISKGGYLQGNMSGRLPSMGDQEPPGQEKVVLKKKITLLRGVSIIIGTVIGSGIFISPKGILQNTGSVGMSLVFWSACGVLSLFGALSYAELGTSIKKSGGHYTYILEVFGPLLAFVRVWVELLVIRPGATAVISLAFGRYILEPFFIQCEIPELAIKLVTAVGITVVMVLNSTSVSWSARIQIFLTFCKLTAILIIIVPGVIQLIKGQTHHFKDAFSGRDTSLMGLPLAFYYGMYAYAGWFYLNFITEEVDNPEKTIPLAICISMAIITVGYVLTNVAYFTTISAEELLQSSAVAVTFSERLLGKFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVHKHTPLPAVIVLHPLTMVMLFSGDLYSLLNFLSFARWLFMGLAVAGLIYLRYKRPDMHRPFKVPLFIPALFSFTCLFMVVLSLYSDPFSTGVGFLITLTGVPAYYLFIVWDKKPKWFRRLSDRITRTLQIILEVVPEDSKEL
uniprot
proteins
function
FUNCTION: Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (Probable) (PubMed:10206947, PubMed:12235164, PubMed:16037214, PubMed:16144837, PubMed:17035536). Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for protection of cells from oxidative stress (PubMed:16037214, PubMed:16144837, PubMed:17035536, PubMed:31396687). The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine (PubMed:10206947). Acts as an inhibitor of ferroptosis by mediating the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis (By similarity). Also inhibits ferroptosis by acting as an atypical proton transporter that mediates a slow proton efflux from lysosomes via cystine and glutamate flux (PubMed:40280132). Glutamate and cystine contain side-chain groups that are protonatable in the physiological range of lysosomal pH and cytosolic pH, respectively, enabling a slow lysosomal proton leak through a substrate-as-proton mechanism (By similarity). Moreover, mediates N-acetyl-L-cysteine uptake into the placenta leading to subsequently down-regulation of pathways associated with oxidative stress, inflammation and apoptosis (By similarity). In vitro can also transport L-aspartate (By similarity). May participate in astrocyte and meningeal cell proliferation during development and can provide neuroprotection by promoting glutathione synthesis and delivery from non-neuronal cells such as astrocytes and meningeal cells to immature neurons (PubMed:17035536). Controls the production of pheomelanin pigment directly (PubMed:16037214). {ECO:0000250|UniProtKB:Q9UPY5, ECO:0000269|PubMed:10206947, ECO:0000269|PubMed:12235164, ECO:0000269|PubMed:16037214, ECO:0000269|PubMed:16144837, ECO:0000269|PubMed:17035536, ECO:0000269|PubMed:31396687, ECO:0000269|PubMed:40280132, ECO:0000305|PubMed:11136724}.
uniprot
proteins
mass_dalton
55456
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by TRIM26; leading to proteasomal degradation. {ECO:0000269|PubMed:33869196}.
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
protein_family
L-type amino acid transporter (LAT) (TC 2.A.3.8) family
uniprot
proteins
pubmed
10206947
uniprot
proteins
pubmed
11136724
uniprot
proteins
pubmed
12235164
uniprot
proteins
pubmed
16037214
uniprot
proteins
pubmed
16144837
uniprot
proteins
pubmed
17035536
uniprot
proteins
pubmed
17200146
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
31396687
uniprot
proteins
pubmed
33869196
uniprot
proteins
pubmed
40280132
uniprot
proteins
sequence_length
502
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9UPY5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UPY5}. Lysosome membrane {ECO:0000250|UniProtKB:Q9UPY5}; Multi-pass membrane protein {ECO:0000255}. Cell projection, microvillus membrane {ECO:0000250|UniProtKB:Q9UPY5}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the microvillous membrane of the placental syncytiotrophoblast. {ECO:0000250|UniProtKB:Q9UPY5}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..64; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9UPY5"; TRANSMEM 75..95; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9UPY5"; TRANSMEM 131..150; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9UPY5"; TRANSMEM 164..179; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9UPY5"; TRANSMEM 194..210; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9UPY5"; TRANSMEM 235..255; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9UPY5"; TRANSMEM 266..286; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9UPY5"; TRANSMEM 318..338; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9UPY5"; TRANSMEM 365..385; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9UPY5"; TRANSMEM 388..408; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9UPY5"; TRANSMEM 423..443; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9UPY5"; TRANSMEM 450..470; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9UPY5
uniprot
proteins