KRT20
entrez
54474
canonical
uniprot
P35900
canonical
ensembl
ENSG00000171431
resolver
ensembl
ENSG00000263057
resolver
ensp
ENSP00000167588
resolver
ensp
ENSP00000460501
resolver
enst
ENST00000167588
resolver
enst
ENST00000576098
resolver
genesymbol
KRT20
resolver
hgnc
HGNC:20412
resolver
uniprot
B2R6W7
resolver
uniprot_entry
K1C20_HUMAN
resolver
uniprot_sec
B2R6W7
resolver
amino_acid_sequence
MDFSRRSFHRSLSSSLQAPVVSTVGMQRLGTTPSVYGGAGGRGIRISNSRHTVNYGSDLTGGGDLFVGNEKMAMQNLNDRLASYLEKVRTLEQSNSKLEVQIKQWYETNAPRAGRDYSAYYRQIEELRSQIKDAQLQNARCVLQIDNAKLAAEDFRLKYETERGIRLTVEADLQGLNKVFDDLTLHKTDLEIQIEELNKDLALLKKEHQEEVDGLHKHLGNTVNVEVDAAPGLNLGVIMNEMRQKYEVMAQKNLQEAKEQFERQTAVLQQQVTVNTEELKGTEVQLTELRRTSQSLEIELQSHLSMKESLEHTLEETKARYSSQLANLQSLLSSLEAQLMQIRSNMERQNNEYHILLDIKTRLEQEIATYRRLLEGEDVKTTEYQLSTLEERDIKKTRKIKTVVQEVVDGKVVSSEVKEVEENI
uniprot
proteins
function
FUNCTION: Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). {ECO:0000250, ECO:0000269|PubMed:12857878, ECO:0000269|PubMed:16608857}.
uniprot
proteins
mass_dalton
48487
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="S->A: Promotes keratin filament disassembly."; /evidence="ECO:0000269|PubMed:16608857"; MUTAGEN 14; /note="S->A: No effect on keratin filament organization."; /evidence="ECO:0000269|PubMed:16608857"; MUTAGEN 80; /note="R->H: Leads to collapsed filaments."; /evidence="ECO:0000269|PubMed:12857878
uniprot
proteins
post_translational_modification
PTM: Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity). {ECO:0000250}.; PTM: Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228. {ECO:0000269|PubMed:16608857}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
10973561
uniprot
proteins
pubmed
12857878
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16608857
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
1696264
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
7689500
uniprot
proteins
pubmed
8359595
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10973561, ECO:0000269|PubMed:1696264}.
uniprot
proteins