STK26
entrez
51765
canonical
uniprot
Q9P289
canonical
ensembl
ENSG00000134602
resolver
ensp
ENSP00000377867
resolver
ensp
ENSP00000377868
resolver
ensp
ENSP00000419702
resolver
genesymbol
STK26
resolver
genesymbol_syn
MASK
resolver
genesymbol_syn
MST4
resolver
hgnc
HGNC:18174
resolver
uniprot
B2RAU2
resolver
uniprot
Q3ZB77
resolver
uniprot
Q8NC04
resolver
uniprot
Q9BXC3
resolver
uniprot
Q9BXC4
resolver
uniprot_entry
STK26_HUMAN
resolver
uniprot_sec
B2RAU2
resolver
uniprot_sec
Q3ZB77
resolver
uniprot_sec
Q8NC04
resolver
uniprot_sec
Q9BXC3
resolver
uniprot_sec
Q9BXC4
resolver
activity_regulation
ACTIVITY REGULATION: Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage. {ECO:0000269|PubMed:15037601}.
uniprot
proteins
amino_acid_sequence
MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:11641781, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:27807006, ECO:0000269|PubMed:29232556}.
uniprot
proteins
mass_dalton
46529
uniprot
proteins
mutagenesis
MUTAGEN 53; /note="K->E: Abolished serine/threonine-protein kinase activity."; /evidence="ECO:0000269|PubMed:29232556
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
11306563
uniprot
proteins
pubmed
11641781
uniprot
proteins
pubmed
11741893
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15037601
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17360971
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18782753
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19370760
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20332113
uniprot
proteins
pubmed
20730082
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27807006
uniprot
proteins
pubmed
29232556
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:27807006}. Golgi apparatus {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:27807006}. Note=Colocalized with RIPOR1 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with RIPOR1 upon serum stimulation in a Rho- and PDCD10-dependent manner (PubMed:27807006). {ECO:0000269|PubMed:27807006}.
uniprot
proteins