Fndc5
entrez
260327
canonical
uniprot
Q8K3V5
canonical
ensembl
ENSRNOG00000030238
resolver
ensembl
ENSRNOG00055027393
resolver
ensembl
ENSRNOG00060020839
resolver
ensembl
ENSRNOG00065023534
resolver
ensp
ENSRNOP00000109827
resolver
ensp
ENSRNOP00055038990
resolver
ensp
ENSRNOP00060029687
resolver
ensp
ENSRNOP00065032758
resolver
enst
ENSRNOT00055047410
resolver
enst
ENSRNOT00060036102
resolver
enst
ENSRNOT00065040257
resolver
genesymbol
Fndc5
resolver
uniprot
A0A8L2QNJ9
resolver
uniprot_entry
FNDC5_RAT
resolver
uniprot_sec
A0A8L2QNJ9
resolver
amino_acid_sequence
MQAARGGAGRPGREGRGLERECERSPGVGAAMPPGPCAWPPRAALRLWLGCVCFALVQADSPSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQGQSPASEPVLFKTPREAEKMASKNKDEVTMKEMGRNQQLRTGEVLIIVVVLFMWAGVIALFCRQYDIIKDNEPNNNKEKTKSASETSTPEHQGGGLLRSKI
uniprot
proteins
function
FUNCTION: [Irisin]: Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. {ECO:0000250|UniProtKB:Q8K4Z2}.
uniprot
proteins
mass_dalton
26442
uniprot
proteins
post_translational_modification
PTM: N-Glycosylated. {ECO:0000250|UniProtKB:Q8K4Z2}.; PTM: The extracellular domain is cleaved and released from the cell membrane. {ECO:0000250|UniProtKB:Q8K4Z2}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Fibronectin type III domain-containing protein 5]: Cell membrane {ECO:0000250|UniProtKB:Q8NAU1}; Single-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000250|UniProtKB:Q8K4Z2}; Single-pass membrane protein {ECO:0000255}. Note=Imported into peroxisomes through the PEX5 receptor pathway. {ECO:0000250|UniProtKB:Q8K4Z2}.; SUBCELLULAR LOCATION: [Irisin]: Secreted {ECO:0000250|UniProtKB:Q8NAU1}. Note=Detected in plasma following endurance exercise. {ECO:0000250|UniProtKB:Q8NAU1}.
uniprot
proteins
transmembrane_region
TRANSMEM 181..201; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins