Lrrc45
entrez
217366
canonical
uniprot
Q8CIM1
canonical
ensembl
ENSMUSG00000025145
resolver
ensp
ENSMUSP00000026139
resolver
enst
ENSMUST00000026139
resolver
genesymbol
Lrrc45
resolver
uniprot
A2AC12
resolver
uniprot
Q3U5Z2
resolver
uniprot_entry
LRC45_MOUSE
resolver
uniprot_sec
A2AC12
resolver
uniprot_sec
Q3U5Z2
resolver
amino_acid_sequence
MEEFRRSYNRLCEESGAEPQEAVLQQLHQLPKGGLDLTTQSLTVETCRALGKLLHKETLLKELVLSDCMLSEEGSTLLFQGLCANTSVQHLDLKGNNLRATGAEALGKLLRQNKSIQSLTLEWNNLGTWEDAFATFCGGLAANSALRQLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNIGLLGGRALVNCLPSNRTLWKLDLAGNNIPGDILRAVEQAMDHNQDRLTAFRENQARTKILSKEVQHLQEEKSKQFLDLMETIDKQREEMARDSRASAVRVGQLQEALNERQSIINALKAKLQMTEAALALSEQKVRDLGELLVAGDQERQSLSQRHEKERKLERQEAADRESKLLRDLSAASEKNLLLRSQVDELERKARSQQEQLFLTKQELTNTSAELKIRAIQAEERLDVEKRRAKQNMEDLEKLHSKEVDHMTRHLEESERAMQERVQRLEALRLSLEEELSRMKAAVLSERGQAEEELIKARNQARLEEQHRLAHLEEKIRLLAQARDEAQGTCVQQKQMVAESQARVSQLNLQMEGQQRRLEELQQELINKDQEKVAEVARVRVELQEQMGRMQADLVAQEALREKVAALERQMKVIGSEHREALLDRESENASLREKLRLKEAEISRIRDEEAQRASFLQNAVLAYVQGSPLRALSPPK
uniprot
proteins
function
FUNCTION: Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. Is probably involved in the early stages of ciliogenesis. Plays a role in the organization of centriolar satellites, likely by regulating the accumulation of centriolar satellite proteins, such as PCM1 and SSX2IP, at the centrosome. {ECO:0000250|UniProtKB:Q96CN5}.
uniprot
proteins
mass_dalton
76384
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NEK2 during misosis, phosphorylation reduces centrosomal localization which subsequently leads to centrosome separation. {ECO:0000250|UniProtKB:Q96CN5}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
670
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q96CN5}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q96CN5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q96CN5}. Note=Localizes to the proteinaceous linker between the proximal ends of the centrioles. Also localized to the distal appendages of the mother centriole. {ECO:0000250|UniProtKB:Q96CN5}.
uniprot
proteins