ST6GALNAC6
entrez
30815
canonical
uniprot
Q969X2
canonical
ensembl
ENSG00000160408
resolver
ensembl
ENSG00000257524
resolver
ensp
ENSP00000362234
resolver
ensp
ENSP00000362235
resolver
ensp
ENSP00000362237
resolver
ensp
ENSP00000362239
resolver
ensp
ENSP00000438109
resolver
ensp
ENSP00000477575
resolver
enst
ENST00000542456
resolver
genesymbol
ST6GALNAC6
resolver
genesymbol_syn
SIAT7F
resolver
hgnc
HGNC:23364
resolver
uniprot
A0A0S2Z5G9
resolver
uniprot
B3KQ01
resolver
uniprot
B4DU80
resolver
uniprot
F6SGE3
resolver
uniprot
Q5T9C4
resolver
uniprot
Q5T9C5
resolver
uniprot
Q9H8A2
resolver
uniprot
Q9ULB8
resolver
uniprot_entry
A0A0S2Z5G9_HUMAN
resolver
uniprot_entry
B4DU80_HUMAN
resolver
uniprot_entry
F6SGE3_HUMAN
resolver
uniprot_entry
SIA7F_HUMAN
resolver
uniprot_sec
B3KQ01
resolver
uniprot_sec
Q5T9C4
resolver
uniprot_sec
Q5T9C5
resolver
uniprot_sec
Q9H8A2
resolver
uniprot_sec
Q9ULB8
resolver
amino_acid_sequence
MACSRPPSQCEPTSLPPGPPAGRRHLPLSRRRREMSSNKEQRSAVFVILFALITILILYSSNSANEVFHYGSLRGRSRRPVNLKKWSITDGYVPILGNKTLPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWGPPSKMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPNYCSQRPRLQRMPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSHPSWT
uniprot
proteins
ec_number
2.4.99.-
uniprot
proteins
function
FUNCTION: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:12668675, PubMed:17123352). Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675). Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity). {ECO:0000250|UniProtKB:Q9JM95, ECO:0000269|PubMed:12668675, ECO:0000269|PubMed:17123352}.
uniprot
proteins
mass_dalton
38068
uniprot
proteins
protein_family
Glycosyltransferase 29 family
uniprot
proteins
pubmed
12668675
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15843597
uniprot
proteins
pubmed
16207893
uniprot
proteins
pubmed
17123352
uniprot
proteins
pubmed
17760270
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..64; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins