RFPL1
entrez
5988
canonical
uniprot
O75677
canonical
ensembl
ENSG00000128250
resolver
ensp
ENSP00000346342
resolver
enst
ENST00000354373
resolver
genesymbol
RFPL1
resolver
genesymbol_syn
RFPL1L
resolver
genesymbol_syn
RNF78
resolver
hgnc
HGNC:9977
resolver
uniprot
Q6IC06
resolver
uniprot
Q9UJ97
resolver
uniprot_entry
RFPL1_HUMAN
resolver
uniprot_sec
Q6IC06
resolver
uniprot_sec
Q9UJ97
resolver
amino_acid_sequence
MKRLSLVTTNRLSPHGNFLPLCTFPLAVDMAALFQEASSCPVCSDYLEKPMSLECGCAVCFKCINSLQKEPHGEDLLCCCCSMVSQKNKIRPSWQLERLASHIKELEPKLKKILQMNPRMRKFQVDMTLDADTANNFLLISDDLRSVRSGCITQNRQDLAERFDVSICILGSPRFTCGRHYWEVDVGTSTEWDLGVCRESVHRKGRIHLTTERGFWTVSLRDGSRLSASTVPLTFLFVDRKLQRVGIFLDMGMQNVSFFDAEGGSHVYTFRSVSAEEPLHLFFAPPSPPNGDKSVLSICPVINPGTTDAPVHPGEAK
uniprot
proteins
function
FUNCTION: Negatively regulates the G2-M phase transition, possibly by promoting cyclin B1/CCNB1 and CDK1 proteasomal degradation and thereby preventing their accumulation during interphase. {ECO:0000269|PubMed:20725088}.
uniprot
proteins
mass_dalton
35491
uniprot
proteins
mutagenesis
MUTAGEN 65..124; /note="Missing: Increased cell proliferation."; /evidence="ECO:0000269|PubMed:20725088"; MUTAGEN 200; /note="S->A: Reduced phosphorylation by PKC, increased cell proliferation, reduced apoptosis and lack of cyclin B1/CCNB1 and CDK1 degradation."; /evidence="ECO:0000269|PubMed:20725088"; MUTAGEN 200; /note="S->E: No effect on cell proliferation."; /evidence="ECO:0000269|PubMed:20725088"; MUTAGEN 287; /note="S->E: Increased cell proliferation, reduced apoptosis and lack of cyclin B1/CCNB1 and CDK1 degradation."; /evidence="ECO:0000269|PubMed:20725088"; MUTAGEN 287; /note="S->G: Reduced phosphorylation by CDK1."; /evidence="ECO:0000269|PubMed:20725088
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKC and CDK1 (PubMed:20725088). The antiproliferative effect seems to be positively regulated by PKC phosphorylation and negatively by CDK1 phosphorylation (PubMed:20725088). {ECO:0000269|PubMed:20725088}.
uniprot
proteins
pubmed
10508838
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20725088
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20725088}. Nucleus {ECO:0000269|PubMed:20725088}. Note=A higher concentration is observed in the cytoplasm compared to the nucleus. {ECO:0000269|PubMed:20725088}.
uniprot
proteins