SOD2
entrez
6648
canonical
uniprot
P04179
canonical
ensembl
ENSG00000291237
resolver
ensp
ENSP00000337127
resolver
ensp
ENSP00000356021
resolver
ensp
ENSP00000356022
resolver
ensp
ENSP00000404804
resolver
ensp
ENSP00000406713
resolver
ensp
ENSP00000442920
resolver
ensp
ENSP00000446252
resolver
enst
ENST00000452684
resolver
genesymbol
SOD2
resolver
hgnc
HGNC:11180
resolver
uniprot
A0A384NL29
resolver
uniprot
B2R7R1
resolver
uniprot
B3KUK2
resolver
uniprot
B4DL20
resolver
uniprot
B4E3K9
resolver
uniprot
E1P5A9
resolver
uniprot
G5E9P6
resolver
uniprot
P78434
resolver
uniprot
Q16792
resolver
uniprot
Q5TCM1
resolver
uniprot
Q96AM7
resolver
uniprot
Q96EE6
resolver
uniprot
Q9P2Z3
resolver
uniprot_entry
A0A384NL29_HUMAN
resolver
uniprot_entry
G5E9P6_HUMAN
resolver
uniprot_entry
Q96AM7_HUMAN
resolver
uniprot_entry
SODM_HUMAN
resolver
uniprot_sec
B2R7R1
resolver
uniprot_sec
B3KUK2
resolver
uniprot_sec
B4DL20
resolver
uniprot_sec
B4E3K9
resolver
uniprot_sec
E1P5A9
resolver
uniprot_sec
P78434
resolver
uniprot_sec
Q16792
resolver
uniprot_sec
Q5TCM1
resolver
uniprot_sec
Q96EE6
resolver
uniprot_sec
Q9P2Z3
resolver
amino_acid_sequence
MLSRAVCGTSRQLAPVLGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
uniprot
proteins
disease_involvement
DISEASE: Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. {ECO:0000269|PubMed:12624725, ECO:0000269|PubMed:18989629}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.15.1.1
uniprot
proteins
function
FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:10334867}.
uniprot
proteins
mass_dalton
24750
uniprot
proteins
mutagenesis
MUTAGEN 58; /note="Y->A,H,N,V,F: Reduced enzyme activity."; /evidence="ECO:0000269|PubMed:10334867"; MUTAGEN 58; /note="Y->F: Loss of nitration. Enhanced dityrosine formation on peroxynitrite treatment."; /evidence="ECO:0000269|PubMed:10334867
uniprot
proteins
post_translational_modification
PTM: Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity. {ECO:0000269|PubMed:10334867, ECO:0000269|PubMed:16399855}.; PTM: Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity). {ECO:0000250|UniProtKB:P09671}.; PTM: Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability. {ECO:0000269|PubMed:21268071}.
uniprot
proteins
protein_family
Iron/manganese superoxide dismutase family
uniprot
proteins
pubmed
10334867
uniprot
proteins
pubmed
10852710
uniprot
proteins
pubmed
11580280
uniprot
proteins
pubmed
12624725
uniprot
proteins
pubmed
1394426
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16399855
uniprot
proteins
pubmed
1699607
uniprot
proteins
pubmed
18989629
uniprot
proteins
pubmed
19265433
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
1988135
uniprot
proteins
pubmed
20668652
uniprot
proteins
pubmed
21268071
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2462451
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2831093
uniprot
proteins
pubmed
3399391
uniprot
proteins
pubmed
3684581
uniprot
proteins
pubmed
6386798
uniprot
proteins
pubmed
7498159
uniprot
proteins
pubmed
7702755
uniprot
proteins
pubmed
7895732
uniprot
proteins
pubmed
8605177
uniprot
proteins
pubmed
9150946
uniprot
proteins
pubmed
9537987
uniprot
proteins
pubmed
9537988
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix.
uniprot
proteins