Gbp5
entrez
229898
canonical
uniprot
Q8CFB4
canonical
ensembl
ENSMUSG00000105504
resolver
ensp
ENSMUSP00000087587
resolver
ensp
ENSMUSP00000143336
resolver
enst
ENSMUST00000196255
resolver
genesymbol
Gbp5
resolver
uniprot
A0A0G2JFW9
resolver
uniprot
E9QJR4
resolver
uniprot
Q8BMN7
resolver
uniprot
Q8CFA4
resolver
uniprot
Q8CFA8
resolver
uniprot_entry
A0A0G2JFW9_MOUSE
resolver
uniprot_entry
GBP5_MOUSE
resolver
uniprot_entry
Q8BMN7_MOUSE
resolver
uniprot_sec
E9QJR4
resolver
uniprot_sec
Q8CFA4
resolver
uniprot_sec
Q8CFA8
resolver
amino_acid_sequence
MAPEIHMPEPLCLIGSTEGHLVTNQEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKEKGFSVGSTVQSHTKGIWMWCVPHPQKPDHTLVLLDTEGLGDVEKDDKKNDTQIFALAILLSSTFVYNTMNKIDQGAIDLLHNVTELTDLLRTRNSSDSNQTEGEGPADMSFFPDLVWTLRDFFLDLQANGHAITSDEYLENSLKLKQGSDERTQTFNLPRLCIQKFFPVKKCFVFDAPALGSKLSQLPTLSNEELNSDFVQDLSEFCSHIFTQSKTKTLPGGIQVNGPRLESLVLTYVDAINSGALPSIENTVVTLARRENSAAVQKAIGHYDQLMSEKVQLPTETLQELLDLHRTCEREAIEIFRKHSFKDEGEFFQKELESLLSAKQDEICKKNADASAALCSTLLGSIFKPLEQEVAQEFYHKPGGHKLFLQRMEQLKANYRQQPGKGTQAEEVLQTYLNAKETVSRTILQTDQVLTDKEIQSKAEQERAEAARLEAQRLEAIRIQEEQRKAEMERQHQEQLRQIALEKARVAQEQQWILKQRAQEEADRIKAEQEAQLRALQQQLQHMREMNHHRRHHHDCVIS
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:22461501, PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716, PubMed:27693356, PubMed:30589883). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis, such as Gm12250/Irgb10: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716, PubMed:27693356, PubMed:30589883). As an activator of NLRP3 inflammasome assembly: promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity by inhibiting FURIN-mediated maturation of viral envelope proteins (By similarity). {ECO:0000250|UniProtKB:Q96PP8, ECO:0000269|PubMed:22461501, ECO:0000269|PubMed:24715728, ECO:0000269|PubMed:24739961, ECO:0000269|PubMed:25774715, ECO:0000269|PubMed:25774716, ECO:0000269|PubMed:27693356, ECO:0000269|PubMed:30589883}.
uniprot
proteins
mass_dalton
66930
uniprot
proteins
post_translational_modification
PTM: Isoprenylation is required for proper subcellular location. {ECO:0000250|UniProtKB:Q96PP8}.
uniprot
proteins
protein_family
GB1 subfamily
uniprot
proteins
protein_family
GB1/RHD3 GTPase family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
12396730
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18025219
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22461501
uniprot
proteins
pubmed
24715728
uniprot
proteins
pubmed
24739961
uniprot
proteins
pubmed
25774715
uniprot
proteins
pubmed
25774716
uniprot
proteins
pubmed
27693356
uniprot
proteins
pubmed
30589883
uniprot
proteins
sequence_length
590
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18025219}; Lipid-anchor {ECO:0000250|UniProtKB:Q96PP8}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q96PP8}; Lipid-anchor {ECO:0000250|UniProtKB:Q96PP8}. Cytoplasm {ECO:0000250|UniProtKB:Q96PP8}.
uniprot
proteins