METAP2
entrez
10988
canonical
uniprot
P50579
canonical
ensembl
ENSG00000111142
resolver
ensp
ENSP00000261220
resolver
ensp
ENSP00000325312
resolver
ensp
ENSP00000448169
resolver
ensp
ENSP00000450063
resolver
enst
ENST00000551840
resolver
genesymbol
METAP2
resolver
genesymbol_syn
MNPEP
resolver
genesymbol_syn
P67EIF2
resolver
hgnc
HGNC:16672
resolver
uniprot
A0A140VJE3
resolver
uniprot
B2RDI8
resolver
uniprot
B4DUX5
resolver
uniprot
F8VQZ7
resolver
uniprot
G3XA91
resolver
uniprot
Q8NB11
resolver
uniprot_entry
A0A140VJE3_HUMAN
resolver
uniprot_entry
F8VQZ7_HUMAN
resolver
uniprot_entry
MAP2_HUMAN
resolver
uniprot_sec
B2RDI8
resolver
uniprot_sec
B4DUX5
resolver
uniprot_sec
G3XA91
resolver
uniprot_sec
Q8NB11
resolver
amino_acid_sequence
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
uniprot
proteins
ec_number
3.4.11.18
uniprot
proteins
function
FUNCTION: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; FUNCTION: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
uniprot
proteins
mass_dalton
52892
uniprot
proteins
post_translational_modification
PTM: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding. {ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:2511207}.
uniprot
proteins
protein_family
Methionine aminopeptidase eukaryotic type 2 subfamily
uniprot
proteins
protein_family
Peptidase M24A family
uniprot
proteins
pubmed
12718546
uniprot
proteins
pubmed
14534293
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15012983
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16134930
uniprot
proteins
pubmed
16540317
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17350258
uniprot
proteins
pubmed
17636946
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20521764
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21537465
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2511207
uniprot
proteins
pubmed
7644482
uniprot
proteins
pubmed
7873610
uniprot
proteins
pubmed
9812898
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:21537465}. Note=About 30% of expressed METAP2 associates with polysomes.
uniprot
proteins