PIRT
entrez
644139
canonical
uniprot
P0C851
canonical
ensembl
ENSG00000233670
resolver
ensp
ENSP00000462046
resolver
ensp
ENSP00000634396
resolver
enst
ENST00000580256
resolver
enst
ENST00000964337
resolver
genesymbol
PIRT
resolver
hgnc
HGNC:37239
resolver
uniprot
B7Z648
resolver
uniprot_entry
PIRT_HUMAN
resolver
uniprot_sec
B7Z648
resolver
amino_acid_sequence
MTMETLPKVLEVDEKSPEAKDLLPSQTASSLCISSRSESVWTTTPRSNWEIYRKPIVIMSVGGAILLFGVVITCLAYTLKLSDKSLSILKMVGPGFLSLGLMMLVCGLVWVPIIKKKQKHRQKSNFLRSLKSFFLTR
uniprot
proteins
function
FUNCTION: Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
15334
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16625196
uniprot
proteins
sequence_length
137
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 56..76; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins