Baiap2
entrez
117542
canonical
uniprot
Q6GMN2
canonical
ensembl
ENSRNOG00000004049
resolver
ensembl
ENSRNOG00055032377
resolver
ensembl
ENSRNOG00060029965
resolver
ensembl
ENSRNOG00065004025
resolver
ensp
ENSRNOP00000005687
resolver
ensp
ENSRNOP00000060172
resolver
ensp
ENSRNOP00000084785
resolver
enst
ENSRNOT00000094446
resolver
genesymbol
Baiap2
resolver
uniprot
A0A8I6A2M9
resolver
uniprot
Q923H3
resolver
uniprot_entry
A0A8I6A2M9_RAT
resolver
uniprot_entry
BAIP2_RAT
resolver
uniprot_sec
Q923H3
resolver
amino_acid_sequence
MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTFAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKAFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPNKIPDRAAQLMQQMANSNGSILPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQENVPVMNGVAGADSEDYNPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLALPPPDYGTSSRAFPSQTAGTFKQRPYSVAVPAFSQGLDDYGARSVSRNPFANVHLKPTVTNDRSAPLLS
uniprot
proteins
function
FUNCTION: Adapter protein that links membrane-bound small G proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions (By similarity). {ECO:0000250|UniProtKB:Q9UQB8}.
uniprot
proteins
mass_dalton
59183
uniprot
proteins
mutagenesis
MUTAGEN 17; /note="Y->F: Loss of phosphorylation; when associated with F-115 and F-178."; /evidence="ECO:0000269|PubMed:11741283"; MUTAGEN 115; /note="Y->F: Loss of phosphorylation; when associated with F-17 and F-178."; /evidence="ECO:0000269|PubMed:11741283"; MUTAGEN 178; /note="Y->F: Loss of phosphorylation; when associated with F-17 and F-115."; /evidence="ECO:0000269|PubMed:11741283
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by INSR in response to insulin treatment. {ECO:0000269|PubMed:11741283}.
uniprot
proteins
pubmed
11514062
uniprot
proteins
pubmed
11741283
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15899863
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
535
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UQB8}. Cell projection, filopodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites (By similarity). {ECO:0000250}.
uniprot
proteins