FOXA2
entrez
3170
canonical
uniprot
Q9Y261
canonical
ensembl
ENSG00000125798
resolver
ensp
ENSP00000366319
resolver
ensp
ENSP00000400341
resolver
genesymbol
FOXA2
resolver
genesymbol_syn
HNF3B
resolver
genesymbol_syn
TCF3B
resolver
hgnc
HGNC:5022
resolver
uniprot
Q8WUW4
resolver
uniprot
Q96DF7
resolver
uniprot_entry
FOXA2_HUMAN
resolver
uniprot_sec
Q8WUW4
resolver
uniprot_sec
Q96DF7
resolver
amino_acid_sequence
MLGAVKMEGHEPSDWSSYYAEPEGYSSVSNMNAGLGMNGMNTYMSMSAAAMGSGSGNMSAGSMNMSSYVGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYANMNSMSPMYGQAGLSRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKQLALKEAAGAAGSGKKAAAGAQASQAQLGEAAGPASETPAGTESPHSSASPCQEHKRGGLGELKGTPAAALSPPEPAPSPGQQQQAAAHLLGPPHHPGLPPEAHLKPEHHYAFNHPFSINNLMSSEQQHHHSHHHHQPHKMDLKAYEQVMHYPGYGSPMPGSLAMGPVTNKTGLDASPLAADTSYYQGVYSRPIMNSS
uniprot
proteins
function
FUNCTION: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}.
uniprot
proteins
mass_dalton
48306
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation. {ECO:0000250}.
uniprot
proteins
pubmed
10672453
uniprot
proteins
pubmed
10899756
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14500912
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15737987
uniprot
proteins
pubmed
19478084
uniprot
proteins
pubmed
19919681
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
35798741
uniprot
proteins
sequence_length
457
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:14500912}. Cytoplasm {ECO:0000269|PubMed:14500912}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
uniprot
proteins