Slc7a5
entrez
50719
canonical
uniprot
Q63016
canonical
ensembl
ENSRNOG00000018824
resolver
ensembl
ENSRNOG00055019934
resolver
ensembl
ENSRNOG00060018608
resolver
ensembl
ENSRNOG00065006751
resolver
ensp
ENSRNOP00000025784
resolver
ensp
ENSRNOP00055027649
resolver
ensp
ENSRNOP00060026042
resolver
ensp
ENSRNOP00065007715
resolver
enst
ENSRNOT00000025784
resolver
enst
ENSRNOT00055034039
resolver
enst
ENSRNOT00060032021
resolver
enst
ENSRNOT00065010492
resolver
genesymbol
Slc7a5
resolver
genesymbol_syn
Lat1
resolver
genesymbol_syn
Mpe16
resolver
genesymbol_syn
Ta1
resolver
uniprot
Q9QWL4
resolver
uniprot_entry
LAT1_RAT
resolver
uniprot_sec
Q9QWL4
resolver
activity_regulation
ACTIVITY REGULATION: L-leucine uptake by TR-iBRB2 cells was inhibited by L-leucine, L-phenylalanine, L-methionine, L-isoleucine, L-valine, L-tyrosine, L-tryptophan, D-leucine, D-phenylalanine, D-methionine and by 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH) (a specific inhibitor of system L transport)(PubMed:15980244). L-phenylalanine uptake is competitively inhibited by aromatic amino acid derivatives including L-DOPA and alpha-methyldopa, and by bulky ligands such as melphalan, triiodothyronine and thyroxine (PubMed:11901210). {ECO:0000269|PubMed:11901210, ECO:0000269|PubMed:15980244}.
uniprot
proteins
amino_acid_sequence
MAVAGAKRRAVAAPATTAAEEERQAREKMLEARRGDGADPEGEGVTLQRNITLINGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLSLVVWAVCGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPVFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFIQMGKDIGQGDASNLHQKLSFEGTNLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTNQMLTSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLMYAFSRDIFSIINFFSFFNWLCVALAIIGMMWLRFKKPELERPIKVNLALPVFFILACLFLIAVSFWKTPLECGIGFAIILSGLPVYFFGVWWKNKPKWILQVIFSVTVLCQKLMQVVPQET
uniprot
proteins
function
FUNCTION: Forms a heterodimer with SLC3A2 that functions as a sodium-independent transporter for large neutral amino acids (PubMed:9726963, PubMed:11311135, PubMed:12614332, PubMed:15980244, PubMed:11901210). Functions as an obligatory amino acid antiporter, mediating the exchange of amino acids and amino acid-related compounds across the plasma membrane (PubMed:9726963, PubMed:15980244, PubMed:11901210). Also mediates sodium-independent exchange of iodothyronines with neutral and aromatic L-alpha-amino acids (By similarity). Mediates exchange of L-tryptophan with the tryptophan metabolites L-kynurenine and 3-hydroxy-L-kynurenine (By similarity). Mediates cellular uptake of iodothyronines, including thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and 3,3'-diiodo-L-thyronine (3,3'-T2), and iodotyrosines including 3-iodo-L-tyrosine (MIT) and 3,5-diiodo-L-tyrosine (DIT) (By similarity). Involved in the uptake of methylmercury (MeHg) when administered as L-cysteine or D,L-homocysteine complexes, thereby contributing to metal ion homeostasis and toxicity (By similarity). Involved in the cellular activity of low-molecular-weight nitrosothiols through stereoselective transport of L-nitrosocysteine (L-CNSO) across the plasma membrane (By similarity). When associated with LAPTM4B, the heterodimer is recruited to lysosomes, where it promotes leucine uptake into these organelles and thereby contributes to mTORC1 activation (By similarity). {ECO:0000250|UniProtKB:Q01650, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11901210, ECO:0000269|PubMed:12614332, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:9726963}.
uniprot
proteins
mass_dalton
55903
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
protein_family
L-type amino acid transporter (LAT) (TC 2.A.3.8) family
uniprot
proteins
pubmed
11095508
uniprot
proteins
pubmed
11311135
uniprot
proteins
pubmed
11901210
uniprot
proteins
pubmed
12614332
uniprot
proteins
pubmed
15120633
uniprot
proteins
pubmed
15980244
uniprot
proteins
pubmed
16027961
uniprot
proteins
pubmed
7532544
uniprot
proteins
pubmed
9726963
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q01650}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q01650}. Cell membrane {ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:16027961}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q01650}. Lysosome membrane {ECO:0000250|UniProtKB:Q01650}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q01650}. Note=Located to the plasma membrane by SLC3A2/4F2hc. Localized to the apical membrane of placental syncytiotrophoblastic cells. Recruited to lysosomes by LAPTM4B (By similarity). Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (PubMed:11095508). {ECO:0000250|UniProtKB:Q01650, ECO:0000269|PubMed:11095508}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..71; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 85..105; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 171..191; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 194..215; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 248..268; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 282..302; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 330..350; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 375..395; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 401..421; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 436..456; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 463..483; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650
uniprot
proteins