Rac2
entrez
19354
canonical
uniprot
Q05144
canonical
ensembl
ENSMUSG00000033220
resolver
ensp
ENSMUSP00000036384
resolver
enst
ENSMUST00000043214
resolver
genesymbol
Rac2
resolver
uniprot
Q3TBC4
resolver
uniprot
Q9D8X9
resolver
uniprot_entry
RAC2_MOUSE
resolver
uniprot_sec
Q3TBC4
resolver
uniprot_sec
Q9D8X9
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. {ECO:0000250|UniProtKB:P15153}.
uniprot
proteins
amino_acid_sequence
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKDIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQPTRQQKRPCSLL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In its active state, binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Regulatory subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). Activates PLCG2. {ECO:0000250|UniProtKB:P15153}.
uniprot
proteins
mass_dalton
21441
uniprot
proteins
protein_family
Rho family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2189110
uniprot
proteins
pubmed
27084103
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Membrane-associated when activated. {ECO:0000250}.
uniprot
proteins