Tmem196
entrez
217951
canonical
uniprot
D3YWQ9
canonical
ensembl
ENSMUSG00000048004
resolver
ensp
ENSMUSP00000054994
resolver
ensp
ENSMUSP00000138921
resolver
ensp
ENSMUSP00000138937
resolver
ensp
ENSMUSP00000139022
resolver
ensp
ENSMUSP00000251180
resolver
enst
ENSMUST00000058644
resolver
enst
ENSMUST00000183694
resolver
genesymbol
Tmem196
resolver
uniprot
V9GX04
resolver
uniprot_entry
TM196_MOUSE
resolver
uniprot_entry
V9GX04_MOUSE
resolver
amino_acid_sequence
MCTSGQIIGSLLVLSVLEIGLGVSSVAVGAVSFSLALREHTPQLGDSSPFLLCGICGILCAKKKSGLVMILFSACCICGLIGGILNFQFLRAVTKKTSSLYPLHLASMSLACIGIGGCTVSSWLTCRLASYEQRRMFSEREHSLHHSHEMAEKEMTDNMSNGAPQLMFNGRVQSMF
uniprot
proteins
function
FUNCTION: Acts as a tumor suppressor in lung cancer (PubMed:26056045, PubMed:36355209). Inhibits tumor cell growth by inhibiting cell proliferation and migration and promoting cell apoptosis (By similarity). Inhibits metastasis of lung cancer by suppressing beta-catenin expression in the Wnt/beta-catenin signaling pathway (PubMed:36355209). {ECO:0000250|UniProtKB:Q5HYL7, ECO:0000269|PubMed:26056045, ECO:0000269|PubMed:36355209}.
uniprot
proteins
mass_dalton
18896
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26056045
uniprot
proteins
pubmed
36355209
uniprot
proteins
sequence_length
176
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5HYL7}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 41..61; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 67..87; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins