Rragb
entrez
245670
canonical
uniprot
Q6NTA4
canonical
ensembl
ENSMUSG00000041658
resolver
ensp
ENSMUSP00000039013
resolver
ensp
ENSMUSP00000181304
resolver
ensp
ENSMUSP00000181310
resolver
ensp
ENSMUSP00000181317
resolver
enst
ENSMUST00000039720
resolver
genesymbol
Rragb
resolver
uniprot
B1AVD6
resolver
uniprot_entry
RRAGB_MOUSE
resolver
uniprot_sec
B1AVD6
resolver
activity_regulation
ACTIVITY REGULATION: The activation of GTP-binding proteins is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). The Ragulator complex functions as a GEF and promotes the active GTP-bound form. The GATOR1 complex functions as a GAP and stimulates RRAGB GTPase activity to turn it into its inactive GDP-bound form, preventing mTORC1 recruitment and activation. {ECO:0000250|UniProtKB:Q5VZM2}.
uniprot
proteins
amino_acid_sequence
MEESDSEKKTEKENVGPKVEPPLGEPEGSLGWAMPNAAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATILDRIHSLQINSSLSTYSLVDSVGNTKTFDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPEAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAEIIEADEVLLFERATFLVISHYQCKEQRDAHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKQCLLMR
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagB/RRAGB is in its active form when GTP-bound RagB/RRAGB forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagB/RRAGB heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. {ECO:0000250|UniProtKB:Q5VZM2}.
uniprot
proteins
mass_dalton
43191
uniprot
proteins
protein_family
GTR/RAG GTP-binding protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25259925
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5VZM2}. Lysosome membrane {ECO:0000250|UniProtKB:Q5VZM2}. Note=Recruited to the lysosome surface by the Ragulator complex. {ECO:0000250|UniProtKB:Q5VZM2}.
uniprot
proteins