Tlr2
entrez
24088
canonical
uniprot
Q9QUN7
canonical
ensembl
ENSMUSG00000027995
resolver
ensp
ENSMUSP00000029623
resolver
enst
ENSMUST00000029623
resolver
genesymbol
Tlr2
resolver
uniprot
G3X8Y8
resolver
uniprot
Q3U400
resolver
uniprot
Q9DBC4
resolver
uniprot_entry
G3X8Y8_MOUSE
resolver
uniprot_entry
TLR2_MOUSE
resolver
uniprot_sec
Q3U400
resolver
uniprot_sec
Q9DBC4
resolver
amino_acid_sequence
MLRALWLFWILVAITVLFSKRCSAQESLSCDASGVCDGRSRSFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETFSEIRRIDFAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLTLHLSESAFLLEIFADILSSVRYLELRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILELSEVEFDDCTLNGLGDFNPSESDVVSELGKVETVTIRRLHIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNLDSFSLFLPRLQELYISRNKLKTLPDASLFPVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFVCSCELLSFTMETPALAQILVDWPDSYLCDSPPRLHGHRLQDARPSVLECHQAALVSGVCCALLLLILLVGALCHHFHGLWYLRMMWAWLQAKRKPKKAPCRDVCYDAFVSYSEQDSHWVENLMVQQLENSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDFSHFRLFDENNDAAILVLLEPIERKAIPQRFCKLRKIMNTKTYLEWPLDEGQQEVFWVNLRTAIKS
uniprot
proteins
function
FUNCTION: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity) (PubMed:15690042). May also promote apoptosis in response to lipoproteins (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (PubMed:17486091). Acts as the major receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PhoS1 (pstS1), in conjunction with TLR1 and for some but not all lipoproteins CD14 and/or CD36. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Recombinant MPT83 from M.tuberculosis stimulates secretion of cytokines (TNF, IL-6 and IL-12p40) by mouse macrophage cell lines in a TLR2-dependent fashion, which leads to increased host innate immunity responses against the bacterium (PubMed:22174456). Lung macrophages which express low levels of TLR2 respond poorly to stimulation by M.tuberculosis LpqH (PubMed:19362712). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (PubMed:27220037). Interacts with TICAM2 (By similarity). {ECO:0000250|UniProtKB:O60603, ECO:0000269|PubMed:15690042, ECO:0000269|PubMed:17486091, ECO:0000269|PubMed:19362712, ECO:0000269|PubMed:22174456, ECO:0000269|PubMed:27220037}.; FUNCTION: (Microbial infection) Mediates activation of bone marrow-derived dendritic cells and macrophages, and production of pro-inflammatory cytokines, such as IL12 (IL12B/IL12A), triggered by Toxoplasma gondii micronemal protein 4 (MIC4) and micronemal protein 1 (MIC1). {ECO:0000269|PubMed:31226171}.
uniprot
proteins
mass_dalton
89449
uniprot
proteins
mutagenesis
MUTAGEN 681; /note="P->H: Abolishes MYD88-binding and response to microbial cell wall components."; /evidence="ECO:0000269|PubMed:10548109
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2. {ECO:0000269|PubMed:27805901}.; PTM: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2. {ECO:0000250|UniProtKB:O60603}.
uniprot
proteins
protein_family
Toll-like receptor family
uniprot
proteins
pubmed
10358136
uniprot
proteins
pubmed
10548109
uniprot
proteins
pubmed
10666214
uniprot
proteins
pubmed
10823826
uniprot
proteins
pubmed
11095740
uniprot
proteins
pubmed
15690042
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17486091
uniprot
proteins
pubmed
17889651
uniprot
proteins
pubmed
18780723
uniprot
proteins
pubmed
19362712
uniprot
proteins
pubmed
19931471
uniprot
proteins
pubmed
22174456
uniprot
proteins
pubmed
22665377
uniprot
proteins
pubmed
25689444
uniprot
proteins
pubmed
26283364
uniprot
proteins
pubmed
27220037
uniprot
proteins
pubmed
27805901
uniprot
proteins
pubmed
31226171
uniprot
proteins
sequence_length
784
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11095740}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:11095740}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000250|UniProtKB:O60603}. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers. {ECO:0000250|UniProtKB:O60603}.
uniprot
proteins
transmembrane_region
TRANSMEM 588..608; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins