Cpt1c
entrez
308579
canonical
uniprot
F1LN46
canonical
ensembl
ENSRNOG00000026163
resolver
ensp
ENSRNOP00000032802
resolver
enst
ENSRNOT00000035908
resolver
genesymbol
Cpt1c
resolver
uniprot
A0A8L2QGW1
resolver
uniprot
Q3KR63
resolver
uniprot_entry
A0A8L2QGW1_RAT
resolver
uniprot_entry
CPT1C_RAT
resolver
uniprot_entry
Q3KR63_RAT
resolver
amino_acid_sequence
MAEAHQASSLLSSLSSDGAEVELSSSVWQEIYLSALRSWKRNLWRVWNDFLAGVVPATPLSWLFLFSTIQLACLLQLDPSLGLMEKIKELLPDWGGQHHQLQGLLAAAVFASCLWGTLIFTLHVALRLLLSHHGWLLEPHGTMSSPTKTWLALVRIFSGRHPRLFSFQRALPRQPVPGAQETVRKYLESMRPVLRDDAFDSVVALANDFLRLQAPRLQLYLQLKSWCASNYVSDWWEEFVYLRSRGSLVNSTYYMMDFLYVTPTPLQAARAGNAVHTLLLYRHLLNRQEIPPTLLMGMRPLCSAQYERMFNTTRIPGVEKDYLCHLQDSQHVAVFHQGRFFRVGTHSSNGLLSPRALEQQFQYILDDPSPACPLEEHLAALTAAPRSMWAQVRESVKTHAATALETVEGAAFFVSLDSEPAGLTRENPAASLDTYAHTLLTGQGHDRWFDKSFTLIVFSNGKLGLSVEHSWADCPVAGHLWEFTLATECFQLGYATDGHCKGHPDPALPKPQRLQWDLPKQIQPSISLALRGAKTLSGNIDCHVFPFFHFGKSFIKGCHVSSDSFIQLVLQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREACQFVRAMENKERTDQQCLALFREAVDKHQALLKAAMSGQGIDRHLFALYIMSRLLHMQSPFLTQVQSQQWLLSTSQIPVQQTHLFDVHNYPDYVSSGGGFGPAHDHGYGVSYIFMGENAISFHISSKQSSTETDSHRLGQHIEDALLDVASLFQAGQQFKRQFTGLGESSGWKYSNLSCKTVDPNIPKSSTNL
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
function
FUNCTION: Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1 (By similarity). Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner (By similarity). Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control (By similarity). Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels (PubMed:18192268, PubMed:24222496). {ECO:0000250|UniProtKB:Q8BGD5, ECO:0000250|UniProtKB:Q8TCG5, ECO:0000269|PubMed:18192268, ECO:0000269|PubMed:24222496}.
uniprot
proteins
mass_dalton
90170
uniprot
proteins
protein_family
Carnitine/choline acetyltransferase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
18192268
uniprot
proteins
pubmed
24222496
uniprot
proteins
sequence_length
801
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q8BGD5}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BGD5}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BGD5}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18192268}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in the soma and dendritic and axonal projections. {ECO:0000250|UniProtKB:Q8BGD5}.
uniprot
proteins
transmembrane_region
TRANSMEM 50..70; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins