Prx
entrez
78960
canonical
uniprot
Q63425
canonical
ensembl
ENSRNOG00000018369
resolver
ensp
ENSRNOP00000110948
resolver
genesymbol
Prx
resolver
uniprot_entry
PRAX_RAT
resolver
amino_acid_sequence
MEARSRSAEELRRAELVEIIVETEAQTGVSGFNVAGGGKEGIFVRELREDSPAAKSLSLQEGDQLLSARVFFENFKYEDALRLLQCAEPYKVSFCLKRTVPTGDLALRPGTVSGYEMKGPRAKVAKLNIQSLSPVKKKKMVIGTLGTPADLAPVDVEFSFPKFSRLRRGLKADAVKGPVPAAPARRRLQLPRLRVREVAEEAQVARMAAAAPPSRKAKSEAEVATGAGFTAPQIELVGPRLPSAEVGVPKVSVPKGTPSTEAASGFALHLPTLGLGAPAAPAVEPPTTGIQVPQVELPTLPSLPTLPTLPCLDTQEGAAVVKVPTLDVAAPSVEVDLALPGAEVEAQGEVPEVALKMPRLSFPRFGVRGKEATEAKVVKGSPEAKAKGPRLRMPTFGLSLLESRPSGPEVAAESKLKLPTLKMPSFGISVAGPEVKAPKGPEVKLPKVPEIKLPKAPEAAIPDVQLPEVQLPKMSDMKLPKIPEMAVPDVHLPEVKLPKVPEMKVPEMKLPKIPEMAVPDVHLPDIQLPKVPEMKLPDMKLPKVPEMAVPDVHLPDIQLPKVPEMKLPDMKLPKVPEMAVPDVRIPEVQLPKVSEVKLPKIPDMAVPDVRLPELQLPKMSEVKLPKIPDMAVPDVRLPEVQLPKVSELKLPKVPEMTMPDIRLPEVQLPKVPDIKLPEIKLPKVPEMAVPDVPLPELQLPKVPQVPDVHLPKVPEMKLPKVPEAQRKSAGAEQAEKTEFSFKLPKMTVPKLGKVTKPGEAGIEVPDKLLILPCLQPEVGTEVARVGVPSLSLPSVELDLPGALGLEGQVQEAVSGKVEKPEGPRVAVGTGEAGFRVPSVEIVNPQLPTVEVKKEQLEMVEMKVKPTSKFSLPKFGLSGPKAVKAEVEGPGRATKLKVSKFAISLPRARAGTDADAKGAGEAGLLPALDLSIPQLSLDAQLPSGKVEVAGAESKPKGSRFALPKFGAKGRDSEADVLVAGEAELEGKGWGWDGKVKMPKLKMPSFGLSRGKEAEIQDGRVSPGEKLEAIAGQLKIPEVELVTPGAQETEKVTSGVKPSGLQVSTTRQVVAEGQEGAQRVSSLGISLPQVELASFGEAGPEIAAPSAEGTVGSRIQVPQVMLELPGTQVAGGDLLVGEGIFKMPTVTVPQLELDVGLGHEAQAGETAKSEGGLKLKLPTLGAGGKGEGAEAQSPEAQHTFHISLPDVELTSPVSSHAEYQVVEGDGDGGHKLKVRLPLFGLARAKEGIETGEKVKSPKLRLPRVGFSQSESASGEGSPSPEEEEEGSGEGASGRRGRVRVRLPRVGLASPSKGSKGQEGDAASKSPVGEKSPKFRFPRVSLSPKARSGSKDREEGGFRVRLPSVGFSETAAPGSARIEGTQAAAI
uniprot
proteins
function
FUNCTION: Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology. {ECO:0000250|UniProtKB:O55103}.
uniprot
proteins
mass_dalton
146400
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.
uniprot
proteins
protein_family
Periaxin family
uniprot
proteins
pubmed
10671475
uniprot
proteins
pubmed
11430802
uniprot
proteins
pubmed
12591166
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8155317
uniprot
proteins
pubmed
9488714
uniprot
proteins
sequence_length
1383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:10671475}. Cytoplasm {ECO:0000269|PubMed:10671475, ECO:0000269|PubMed:8155317}. Cell membrane {ECO:0000269|PubMed:10671475, ECO:0000269|PubMed:11430802, ECO:0000269|PubMed:8155317}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Detected in the Schwann cell nucleus prior to the onset of myelination (By similarity). Detected in Schwann cells at periaxonal myelin membranes (PubMed:10671475, PubMed:11430802, PubMed:8155317). Associated with the cell membrane during myelination (By similarity). {ECO:0000250|UniProtKB:O55103, ECO:0000269|PubMed:10671475, ECO:0000269|PubMed:11430802, ECO:0000269|PubMed:8155317}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:O55103}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O55103}. Cell junction {ECO:0000250|UniProtKB:O55103}. Note=Colocalizes with ACTB at tricellular junctions between eye lens fiber cells. {ECO:0000250|UniProtKB:O55103}.
uniprot
proteins