MLLT6
entrez
4302
canonical
uniprot
P55198
canonical
ensembl
ENSG00000275023
resolver
ensembl
ENSG00000275851
resolver
ensp
ENSP00000477969
resolver
ensp
ENSP00000479910
resolver
enst
ENST00000618876
resolver
enst
ENST00000621332
resolver
genesymbol
MLLT6
resolver
genesymbol_syn
AF17
resolver
hgnc
HGNC:7138
resolver
uniprot
Q59F28
resolver
uniprot
Q96IU3
resolver
uniprot
Q9H5F6
resolver
uniprot
Q9UF49
resolver
uniprot_entry
AF17_HUMAN
resolver
uniprot_sec
Q59F28
resolver
uniprot_sec
Q96IU3
resolver
uniprot_sec
Q9H5F6
resolver
uniprot_sec
Q9UF49
resolver
amino_acid_sequence
MKEMVGGCCVCSDERGWAENPLVYCDGHACSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVLTMEPIVLQYVPHDRFNKTCYICEEQGRESKAASGACMTCNRHGCRQAFHVTCAQMAGLLCEEEVLEVDNVKYCGYCKYHFSKMKTSRHSSGGGGGGAGGGGGSMGGGGSGFISGRRSRSASPSTQQEKHPTHHERGQKKSRKDKERLKQKHKKRPESPPSILTPPVVPTADKVSSSASSSSHHEASTQETSESSRESKGKKSSSHSLSHKGKKLSSGKGVSSFTSASSSSSSSSSSSGGPFQPAVSSLQSSPDFSAFPKLEQPEEDKYSKPTAPAPSAPPSPSAPEPPKADLFEQKVVFSGFGPIMRFSTTTSSSGRARAPSPGDYKSPHVTGSGASAGTHKRMPALSATPVPADETPETGLKEKKHKASKRSRHGPGRPKGSRNKEGTGGPAAPSLPSAQLAGFTATAASPFSGGSLVSSGLGGLSSRTFGPSGSLPSLSLESPLLGAGIYTSNKDPISHSGGMLRAVCSTPLSSSLLGPPGTSALPRLSRSPFTSTLPSSSASISTTQVFSLAGSTFSLPSTHIFGTPMGAVNPLLSQAESSHTEPDLEDCSFRCRGTSPQESLSSMSPISSLPALFDQTASAPCGGGQLDPAAPGTTNMEQLLEKQGDGEAGVNIVEMLKALHALQKENQRLQEQILSLTAKKERLQILNVQLSVPFPALPAALPAANGPVPGPYGLPPQAGSSDSLSTSKSPPGKSSLGLDNSLSTSSEDPHSGCPSRSSSSLSFHSTPPPLPLLQQSPATLPLALPGAPAPLPPQPQNGLGRAPGAAGLGAMPMAEGLLGGLAGSGGLPLNGLLGGLNGAAAPNPASLSQAGGAPTLQLPGCLNSLTEQQRHLLQQQEQQLQQLQQLLASPQLTPEHQTVVYQMIQQIQQKRELQRLQMAGGSQLPMASLLAGSSTPLLSAGTPGLLPTASAPPLLPAGALVAPSLGNNTSLMAAAAAAAAVAAAGGPPVLTAQTNPFLSLSGAEGSGGGPKGGTADKGASANQEKG
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving MLLT6 is associated with acute leukemias. Translocation t(11;17)(q23;q21) with KMT2A/MLL1. The result is a rogue activator protein. {ECO:0000269|PubMed:8058765}.
uniprot
proteins
function
FUNCTION: Involved in the stimulation of renal sodium reabsorption mediated by the epithelial sodium channel (ENaC) (By similarity). Up-regulates ENaC expression in renal collecting duct cells by promoting DOT1L export from the nucleus to the cytoplasm, thus limiting DOT1L-mediated H3K79 methylation and transcriptional repression at the SCNN1A promoter (PubMed:19864429, PubMed:22087315). {ECO:0000250|UniProtKB:B1AR09, ECO:0000269|PubMed:19864429, ECO:0000269|PubMed:22087315}.
uniprot
proteins
mass_dalton
112048
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19864429
uniprot
proteins
pubmed
22087315
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26439302
uniprot
proteins
pubmed
8058765
uniprot
proteins
sequence_length
1093
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22087315}. Cytoplasm {ECO:0000269|PubMed:22087315}.
uniprot
proteins