Clybl
entrez
306198
canonical
uniprot
Q5I0K3
canonical
ensembl
ENSRNOG00000014075
resolver
ensembl
ENSRNOG00060008800
resolver
ensp
ENSRNOP00000018918
resolver
genesymbol
Clybl
resolver
uniprot_entry
CLYBL_RAT
resolver
amino_acid_sequence
MALCVLQNAVRGAAALPRLKASLVASVCRPGYSSLSNHKYVPRRAVLYVPGNDEKKIRKIPSLKVDCAVLDCEDGVAENKKNEARLRIAKTLEDFDLGTTEKCVRINSVSSGLAEADLETFLQARVLPSSLMLPKVEGPEEIQWFSDKFSLHLKGRKLEQPMNLIPFVETAMGLLNFKAVCEETLKIGPQVGLFLDAVVFGGEDFRASIGATSNKDTQDILYARQKIVVTAKAFGLQAIDLVYIDFRDEDGLLRQSREAAAMGFTGKQVIHPNQIAVVQEQFTPTPEKIRWAEELIAAFKEHQQLGKGAFTFQGSMIDMPLLKQAQNIVTLATSIKEK
uniprot
proteins
ec_number
2.3.3.-
uniprot
proteins
ec_number
2.3.3.9
uniprot
proteins
ec_number
3.1.2.30
uniprot
proteins
ec_number
4.1.3.25
uniprot
proteins
function
FUNCTION: Mitochondrial enzyme required to detoxify vitamin B12-poisoning metabolites. Acts as a citramalyl-CoA lyase by converting citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway, a pathway required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malyl-CoA thioesterase to detoxify malyl-CoA, a side product of citric acid cycle enzymes, which is toxic for the vitamin B12-dependent enzyme MMUT. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate. Also has very weak citramalate synthase activity in vitro. {ECO:0000250|UniProtKB:Q8N0X4}.
uniprot
proteins
mass_dalton
37321
uniprot
proteins
protein_family
Citrate lyase beta subunit-like subfamily
uniprot
proteins
protein_family
HpcH/HpaI aldolase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8R4N0}.
uniprot
proteins