SPSB3
entrez
90864
canonical
uniprot
Q6PJ21
canonical
ensembl
ENSG00000162032
resolver
ensp
ENSP00000301717
resolver
ensp
ENSP00000457206
resolver
ensp
ENSP00000560639
resolver
ensp
ENSP00000560640
resolver
ensp
ENSP00000560642
resolver
ensp
ENSP00000560644
resolver
ensp
ENSP00000560646
resolver
ensp
ENSP00000560647
resolver
ensp
ENSP00000560649
resolver
ensp
ENSP00000635256
resolver
ensp
ENSP00000635257
resolver
enst
ENST00000301717
resolver
enst
ENST00000566339
resolver
enst
ENST00000890581
resolver
enst
ENST00000890583
resolver
enst
ENST00000890585
resolver
enst
ENST00000890587
resolver
enst
ENST00000890588
resolver
enst
ENST00000890590
resolver
enst
ENST00000965197
resolver
enst
ENST00000965198
resolver
genesymbol
SPSB3
resolver
genesymbol_syn
C16orf31
resolver
genesymbol_syn
SSB3
resolver
hgnc
HGNC:30629
resolver
uniprot
D3DU78
resolver
uniprot
Q49A96
resolver
uniprot
Q86X18
resolver
uniprot
Q8WXK5
resolver
uniprot
Q96IE6
resolver
uniprot
Q96RY2
resolver
uniprot_entry
SPSB3_HUMAN
resolver
uniprot_sec
D3DU78
resolver
uniprot_sec
Q49A96
resolver
uniprot_sec
Q86X18
resolver
uniprot_sec
Q8WXK5
resolver
uniprot_sec
Q96IE6
resolver
uniprot_sec
Q96RY2
resolver
amino_acid_sequence
MARRPRNSRAWHFVLSAARRDADARAVALAGSTNWGYDSDGQHSDSDSDPEYSTLPPSIPSAVPVTGESFCDCAGQSEASFCSSLHSAHRGRDCRCGEEDEYFDWVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGEGQHFWEIKMTSPVYGTDMMVGIGTSDVDLDKYRHTFCSLLGRDEDSWGLSYTGLLHHKGDKTSFSSRFGQGSIIGVHLDTWHGTLTFFKNRKCIGVAATKLQNKRFYPMVCSTAARSSMKVTRSCASATSLQYLCCHRLRQLRPDSGDTLEGLPLPPGLKQVLHNKLGWVLSMSCSRRKAPVSDPQAATSAHPSSREPRPCQRKRCRRT
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CGAS and SNAI1 (PubMed:29059170, PubMed:38418882). The ECS(SPSB3) complex catalyzes 'Lys-48'-linked ubiquitination of nuclear CGAS in cycling cells, leading to its degradation (PubMed:38418882). Recognizes and binds nucleosome-bound CGAS: ubiquitination and degradation of nuclear CGAS during G1 and G2 phases is required to promote low intranuclear CGAS abundance before the next mitotic cycle (PubMed:38418882). The ECS(SPSB3) complex also mediates ubiquitination and degradation of phosphorylated SNAI1 (PubMed:29059170). {ECO:0000269|PubMed:29059170, ECO:0000269|PubMed:38418882}.
uniprot
proteins
mass_dalton
39376
uniprot
proteins
mutagenesis
MUTAGEN 160..162; /note="YGT->AGA: Abolished interaction with CGAS; when associated with 259-A--A-262."; /evidence="ECO:0000269|PubMed:38418882"; MUTAGEN 259..262; /note="TAAR->AAAA: Abolished interaction with CGAS; when associated with 160-A--A-162."; /evidence="ECO:0000269|PubMed:38418882
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:29059170, ECO:0000269|PubMed:38418882}.
uniprot
proteins
protein_family
SPSB family
uniprot
proteins
pubmed
11157797
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15713673
uniprot
proteins
pubmed
29059170
uniprot
proteins
pubmed
38418882
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:38418882}. Note=Nuclear SPSB3 levels increase during interphase. {ECO:0000269|PubMed:38418882}.
uniprot
proteins