Polr1c
entrez
20016
canonical
uniprot
P52432
canonical
ensembl
ENSMUSG00000067148
resolver
ensp
ENSMUSP00000084252
resolver
enst
ENSMUST00000087026
resolver
genesymbol
Polr1c
resolver
genesymbol_syn
Rpo1-1
resolver
uniprot
Q3UJZ9
resolver
uniprot_entry
RPAC1_MOUSE
resolver
uniprot_sec
Q3UJZ9
resolver
amino_acid_sequence
MAAAQAVEEMRTRVVLGEFGVRNVHTTDFPGNYAGYDDAWDQNRFEKNFRVDVVQMDEDTLEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPILADPRLFEYRNQGEEEGTEIDTLQFRLQVRCTRNPNAAKDSSDPNELYVNHKVYTRHMTWVPLGNQADVFPEGTIRPVHDDILIAQLRPGQEIDLMMHCVKGIGKDHAKFSPVATASYRLLPAITLLEPVEGEAAEELSQCFSPGVIEVEEVQGKKVARVANARLDTFSREIFRHEKLKKAVRLARVRDHYIFSVESTGVLPPDVLVSEAIKILMGKCRRFLDELDAVEMD
uniprot
proteins
function
FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. POLR1C/RPAC1 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft (By similarity). {ECO:0000250|UniProtKB:O15160, ECO:0000250|UniProtKB:P07703}.
uniprot
proteins
mass_dalton
39107
uniprot
proteins
mutagenesis
MUTAGEN 73; /note="A->D: Unable to interact with RPB14."; /evidence="ECO:0000269|PubMed:9099876"; MUTAGEN 73; /note="A->R: Temperature-sensitive defect in the interaction with RPB14."; /evidence="ECO:0000269|PubMed:9099876
uniprot
proteins
protein_family
Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7929437
uniprot
proteins
pubmed
9099876
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O15160}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O15160}.
uniprot
proteins