Rnf167
entrez
70510
canonical
uniprot
Q91XF4
canonical
ensembl
ENSMUSG00000040746
resolver
ensp
ENSMUSP00000036472
resolver
enst
ENSMUST00000037534
resolver
genesymbol
Rnf167
resolver
uniprot
Q3U4S5
resolver
uniprot_entry
RN167_MOUSE
resolver
uniprot_sec
Q3U4S5
resolver
amino_acid_sequence
MHPAAFPLPVVVATVLWGAAPVRGLIRATSEHNASMDFADLPALFGATLSDEGLQGFLVEAHPENACGPIAPPPSAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNVNSNELLNMVWNSEEIQQQIWIPSVFIGERSAEYLRALFVYEKGARVLLVPDNSFPLGYYLIPFTGIVGLLVLAMGTVLIVRCIQHRKRLQRNRLTKEQLKQIPTHDYQKGDEYDVCAICLDEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEEQEEETQEQEEGDEGEPRDQPASEWTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPSPPSSAALA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway. Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1. Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex. Also involved in protein trafficking and localization. Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2. Does not catalyze ubiquitination of GluA1/GRIA1. Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3. Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B. Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18. Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N. {ECO:0000250|UniProtKB:Q9H6Y7}.
uniprot
proteins
mass_dalton
38014
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9H6Y7}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated in vitro in the presence of UBE2D1 and UBE2E1. {ECO:0000250|UniProtKB:Q9H6Y7}.
uniprot
proteins
protein_family
Godzilla family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
347
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9H6Y7}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:Q9H6Y7}; Single-pass type I membrane protein {ECO:0000255}. Endomembrane system {ECO:0000250|UniProtKB:Q9H6Y7}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9H6Y7}; Single-pass type I membrane protein {ECO:0000255}. Note=Targeted to cytoplasmic membranes; mainly localizes to lysosomal membrane. A subpopulation localizes to the cell membrane of neurons. {ECO:0000250|UniProtKB:Q9H6Y7}.
uniprot
proteins
transmembrane_region
TRANSMEM 174..194; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins