GEMIN8
entrez
54960
canonical
uniprot
Q9NWZ8
canonical
ensembl
ENSG00000046647
resolver
ensp
ENSP00000369895
resolver
ensp
ENSP00000381398
resolver
ensp
ENSP00000505279
resolver
ensp
ENSP00000505429
resolver
ensp
ENSP00000559553
resolver
ensp
ENSP00000559555
resolver
ensp
ENSP00000559557
resolver
ensp
ENSP00000559560
resolver
ensp
ENSP00000559562
resolver
ensp
ENSP00000585261
resolver
ensp
ENSP00000585262
resolver
ensp
ENSP00000585263
resolver
ensp
ENSP00000585264
resolver
ensp
ENSP00000585265
resolver
ensp
ENSP00000635194
resolver
ensp
ENSP00000635195
resolver
ensp
ENSP00000635196
resolver
ensp
ENSP00000635197
resolver
enst
ENST00000380523
resolver
enst
ENST00000398355
resolver
enst
ENST00000477386
resolver
enst
ENST00000680255
resolver
enst
ENST00000889493
resolver
enst
ENST00000889496
resolver
enst
ENST00000889498
resolver
enst
ENST00000889501
resolver
enst
ENST00000889503
resolver
enst
ENST00000915202
resolver
enst
ENST00000915203
resolver
enst
ENST00000915204
resolver
enst
ENST00000915205
resolver
enst
ENST00000915206
resolver
enst
ENST00000965135
resolver
enst
ENST00000965136
resolver
enst
ENST00000965137
resolver
enst
ENST00000965138
resolver
genesymbol
GEMIN8
resolver
genesymbol_syn
FAM51A1
resolver
hgnc
HGNC:26044
resolver
uniprot
C4AMC4
resolver
uniprot
Q2LJ66
resolver
uniprot
Q6ZV27
resolver
uniprot_entry
GEMI8_HUMAN
resolver
uniprot_sec
C4AMC4
resolver
uniprot_sec
Q2LJ66
resolver
uniprot_sec
Q6ZV27
resolver
amino_acid_sequence
MAAVKASTSKATRPWYSHPVYARYWQHYHQAMAWMQSHHNAYRKAVESCFNLPWYLPSALLPQSSYDNEAAYPQSFYDHHVAWQDYPCSSSHFRRSGQHPRYSSRIQASTKEDQALSKEEEMETESDAEVECDLSNMEITEELRQYFAETERHREERRRQQQLDAERLDSYVNADHDLYCNTRRSVEAPTERPGERRQAEMKRLYGDSAAKIQAMEAAVQLSFDKHCDRKQPKYWPVIPLKF
uniprot
proteins
function
FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. {ECO:0000269|PubMed:17023415, ECO:0000269|PubMed:18984161}.
uniprot
proteins
mass_dalton
28637
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16434402
uniprot
proteins
pubmed
17023415
uniprot
proteins
pubmed
17178713
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18984161
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
33754639
uniprot
proteins
sequence_length
242
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, gem {ECO:0000269|PubMed:16434402}. Cytoplasm {ECO:0000269|PubMed:16434402}. Note=Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
uniprot
proteins