Ndel1
entrez
170845
canonical
uniprot
Q78PB6
canonical
ensembl
ENSRNOG00000004139
resolver
ensp
ENSRNOP00000005574
resolver
ensp
ENSRNOP00000097143
resolver
ensp
ENSRNOP00000101084
resolver
enst
ENSRNOT00000131309
resolver
genesymbol
Ndel1
resolver
genesymbol_syn
Nude2
resolver
genesymbol_syn
Nudel
resolver
uniprot
A0ABK0L9S6
resolver
uniprot
Q6IRI4
resolver
uniprot_entry
A0ABK0L9S6_RAT
resolver
uniprot_entry
NDEL1_RAT
resolver
uniprot_sec
Q6IRI4
resolver
amino_acid_sequence
MDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENSFPSPKAIPNGFGTSPLTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYVPGSVNCGVMNSNGPECPRSGRATFFHKGAVNGFDPAPPPPGLGSSRPSSAPGMLPLSV
uniprot
proteins
function
FUNCTION: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth. May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9ERR1, ECO:0000250|UniProtKB:Q9GZM8, ECO:0000269|PubMed:17035248}.
uniprot
proteins
mass_dalton
38366
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE (By similarity). {ECO:0000250}.; PTM: Palmitoylation at Cys-273 reduces affinity for dynein. {ECO:0000250}.
uniprot
proteins
protein_family
NudE family
uniprot
proteins
pubmed
11163260
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15728732
uniprot
proteins
pubmed
17035248
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
345
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the mitotic spindle and to the microtubules of the manchette in elongated spermatids (By similarity). Localizes to the interphase centrosome. Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Colocalizes with DISC1 in the perinuclear region, including the centrosome. {ECO:0000250}.
uniprot
proteins