Rgma
entrez
244058
canonical
uniprot
Q6PCX7
canonical
ensembl
ENSMUSG00000070509
resolver
ensp
ENSMUSP00000091870
resolver
ensp
ENSMUSP00000145758
resolver
genesymbol
Rgma
resolver
uniprot
Q7TQ34
resolver
uniprot
Q8CIH6
resolver
uniprot_entry
RGMA_MOUSE
resolver
uniprot_sec
Q7TQ34
resolver
uniprot_sec
Q8CIH6
resolver
amino_acid_sequence
MQPPRERLVVTGRAGWMGMGRGAGRSALGLWPTLAFLLCSFPAAISPCKILKCNSEFWSATSSGSHAPASDDVPEFCAALRTYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNCSKDGPTSQPRVRTLPPAGDSQERSDSPEICHYEKSFHKHSAAPNYTHCGLFGDPHLRTFTDHFQTCKVQGAWPLIDNNYLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPSAFADGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEEVVNAVEDRDSQGLYLCLRGCPLNQQIDFQAFRANAESPRRPAAASPSPVVPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTTGDVNFTLAAYYALEDGKMLHSNKDKLHLFERTRELPGAVAAAAAAATTFPLAPQILLGTIPLLVLLPVLW
uniprot
proteins
function
FUNCTION: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. {ECO:0000269|PubMed:14749425, ECO:0000269|PubMed:15084667, ECO:0000269|PubMed:15975920, ECO:0000269|PubMed:17389603, ECO:0000269|PubMed:17472960, ECO:0000269|PubMed:17953666, ECO:0000269|PubMed:18519029}.
uniprot
proteins
mass_dalton
49676
uniprot
proteins
post_translational_modification
PTM: Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds. {ECO:0000250}.
uniprot
proteins
protein_family
Repulsive guidance molecule (RGM) family
uniprot
proteins
pubmed
14678836
uniprot
proteins
pubmed
14749425
uniprot
proteins
pubmed
15084667
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15975920
uniprot
proteins
pubmed
17389603
uniprot
proteins
pubmed
17472960
uniprot
proteins
pubmed
17953666
uniprot
proteins
pubmed
18519029
uniprot
proteins
sequence_length
454
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
uniprot
proteins