PLXDC1
entrez
57125
canonical
uniprot
Q8IUK5
canonical
ensembl
ENSG00000161381
resolver
ensp
ENSP00000323927
resolver
ensp
ENSP00000409687
resolver
ensp
ENSP00000551115
resolver
ensp
ENSP00000551116
resolver
ensp
ENSP00000680850
resolver
ensp
ENSP00000680853
resolver
genesymbol
PLXDC1
resolver
genesymbol_syn
TEM3
resolver
genesymbol_syn
TEM7
resolver
hgnc
HGNC:20945
resolver
uniprot
B2R7I8
resolver
uniprot
Q5QCZ7
resolver
uniprot
Q5QCZ8
resolver
uniprot
Q5QCZ9
resolver
uniprot
Q9HCT9
resolver
uniprot_entry
PLDX1_HUMAN
resolver
uniprot_sec
B2R7I8
resolver
uniprot_sec
Q5QCZ7
resolver
uniprot_sec
Q5QCZ8
resolver
uniprot_sec
Q5QCZ9
resolver
uniprot_sec
Q9HCT9
resolver
amino_acid_sequence
MRGELWLLVLVLREAARALSPQPGAGHDEGPGSGWAAKGTVRGWNRRARESPGHVSEPDRTQLSQDLGGGTLAMDTLPDNRTRVVEDNHSYYVSRLYGPSEPHSRELWVDVAEANRSQVKIHTILSNTHRQASRVVLSFDFPFYGHPLRQITIATGGFIFMGDVIHRMLTATQYVAPLMANFNPGYSDNSTVVYFDNGTVFVVQWDHVYLQGWEDKGSFTFQAALHHDGRIVFAYKEIPMSVPEISSSQHPVKTGLSDAFMILNPSPDVPESRRRSIFEYHRIELDPSKVTSMSAVEFTPLPTCLQHRSCDACMSSDLTFNCSWCHVLQRCSSGFDRYRQEWMDYGCAQEAEGRMCEDFQDEDHDSASPDTSFSPYDGDLTTTSSSLFIDSLTTEDDTKLNPYAGGDGLQNNLSPKTKGTPVHLGTIVGIVLAVLLVAAIILAGIYINGHPTSNAALFFIERRPHHWPAMKFRSHPDHSTYAEVEPSGHEKEGFMEAEQC
uniprot
proteins
function
FUNCTION: Plays a critical role in endothelial cell capillary morphogenesis. {ECO:0000250}.
uniprot
proteins
mass_dalton
55760
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:15574754}.
uniprot
proteins
protein_family
Plexin family
uniprot
proteins
pubmed
10947988
uniprot
proteins
pubmed
11559528
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15574754
uniprot
proteins
pubmed
16574105
uniprot
proteins
pubmed
17560052
uniprot
proteins
pubmed
18316703
uniprot
proteins
pubmed
25326458
uniprot
proteins
pubmed
36213313
uniprot
proteins
pubmed
37453717
uniprot
proteins
sequence_length
500
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:37453717}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 427..447; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins