Mras
entrez
17532
canonical
uniprot
O08989
canonical
ensembl
ENSMUSG00000032470
resolver
ensp
ENSMUSP00000035045
resolver
ensp
ENSMUSP00000112407
resolver
ensp
ENSMUSP00000113275
resolver
ensp
ENSMUSP00000230375
resolver
ensp
ENSMUSP00000330062
resolver
enst
ENSMUST00000035045
resolver
enst
ENSMUST00000119472
resolver
enst
ENSMUST00000122384
resolver
genesymbol
Mras
resolver
genesymbol_syn
Xras
resolver
uniprot
Q3TPX5
resolver
uniprot_entry
Q3TPX5_MOUSE
resolver
uniprot_entry
RASM_MOUSE
resolver
amino_acid_sequence
MATSAVPSENLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHLRKVTRDQGKEMATKYNIPYIETSAKDPPLNVDKTFHDLVRVIRQQVPEKNQKKKKKTKWRGDRATGTHKLQCVIL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (By similarity). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (By similarity). The formation of the SMP complex only occurs when MRAS is GTP-bound (By similarity). MRAS has low intrinsic GTPase activity and may require additional factors for activation (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity). {ECO:0000250|UniProtKB:O14807}.
uniprot
proteins
mass_dalton
23901
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10477695
uniprot
proteins
pubmed
11313946
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9395237
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
uniprot
proteins