Hat1
entrez
107435
canonical
uniprot
Q8BY71
canonical
ensembl
ENSMUSG00000027018
resolver
ensp
ENSMUSP00000028408
resolver
enst
ENSMUST00000028408
resolver
genesymbol
Hat1
resolver
uniprot_entry
HAT1_MOUSE
resolver
amino_acid_sequence
MAALEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTLFRVEYSSKVDENFDCVEADDVEGKIRQIIPPGFCTNTNDFLSLLEKETNFKPFGTLLHTYTVPSQTGGETFTFQIHKADMTCRGFREYHERLQTFLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYISFPTVLDITAEDPSRSYLKLRDFVLVKFCQFLPSFSRERLLQGFSEDMAIQAQQMFKINKQHARRVYEILRLLVTDMSDAEQYRSYRLDIKRRLISPYKKKQRDLAKMKKCLRPEELTNQMNQIEISVQHEQLEERFQELVEDYRRVIERLAQE
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.48
uniprot
proteins
function
FUNCTION: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:23754951). Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). Drives H4 production by chromatin binding to support chromatin replication and acetylation (PubMed:23754951). Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression. Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks (PubMed:23754951). In addition, acetylates other substrates such as chromatin-related proteins. Also acetylates RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation (By similarity). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-methylpropenoyl-CoA (methacryl-CoA), and is able to mediate histone methacrylation (By similarity). {ECO:0000250|UniProtKB:O14929, ECO:0000269|PubMed:23754951}.
uniprot
proteins
mass_dalton
49278
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by AMPK at Ser-187; phosphorylation increases HAT1 activity. {ECO:0000250|UniProtKB:O14929}.
uniprot
proteins
protein_family
HAT1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23754951
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250|UniProtKB:O14929}. Mitochondrion {ECO:0000250|UniProtKB:O14929}.
uniprot
proteins