PI4K2B
entrez
55300
canonical
uniprot
Q8TCG2
canonical
ensembl
ENSG00000038210
resolver
ensp
ENSP00000264864
resolver
ensp
ENSP00000423373
resolver
ensp
ENSP00000541597
resolver
ensp
ENSP00000633258
resolver
enst
ENST00000264864
resolver
enst
ENST00000512921
resolver
enst
ENST00000871538
resolver
genesymbol
PI4K2B
resolver
hgnc
HGNC:18215
resolver
uniprot
G5E9Z4
resolver
uniprot
Q9NUW2
resolver
uniprot_entry
G5E9Z4_HUMAN
resolver
uniprot_entry
P4K2B_HUMAN
resolver
uniprot_sec
Q9NUW2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by phenylarsine oxide and adenosine (PubMed:11923287). Activation through membrane association is stimulated by active RAC1 (PubMed:12324459). {ECO:0000269|PubMed:11923287, ECO:0000269|PubMed:12324459}.
uniprot
proteins
amino_acid_sequence
MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAHPRRGAPGSAVRLLDAAGEEGEAGDEELPLPPGDVGVSRSSSAELDRSRPAVSVTIGTSEMNAFLDDPEFADIMLRAEQAIEVGIFPERISQGSSGSYFVKDPKRKIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCLIPNQGYLSEAGAYLVDNKLHLSIVPKTKVVWLVSETFNYNAIDRAKSRGKKYALEKVPKVGRKFHRIGLPPKIGSFQLFVEGYKEAEYWLRKFEADPLPENIRKQFQSQFERLVILDYIIRNTDRGNDNWLVRYEKQKCEKEIDHKESKWIDDEEFLIKIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKVPFSEEIRNLILPYISDMNFVQDLCEDLYELFKTDKGFDKATFESQMSVMRGQILNLTQALRDGKSPFQLVQIPCVIVERSQGGSQGRIVHLSNSFTQTVNCRKPFFSSW
uniprot
proteins
ec_number
2.7.1.67
uniprot
proteins
function
FUNCTION: Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell (PubMed:11923287, PubMed:12324459). This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments (PubMed:11923287, PubMed:12324459). The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (PubMed:11923287, PubMed:12324459). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. {ECO:0000269|PubMed:11923287, ECO:0000269|PubMed:12324459}.
uniprot
proteins
mass_dalton
54744
uniprot
proteins
mutagenesis
MUTAGEN 304; /note="D->A: Increased localization to plasma membrane."; /evidence="ECO:0000269|PubMed:11923287
uniprot
proteins
protein_family
PI3/PI4-kinase family
uniprot
proteins
protein_family
Type II PI4K subfamily
uniprot
proteins
pubmed
11923287
uniprot
proteins
pubmed
12324459
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26143926
uniprot
proteins
sequence_length
481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12324459}. Golgi apparatus membrane {ECO:0000269|PubMed:11923287, ECO:0000269|PubMed:12324459}; Peripheral membrane protein {ECO:0000269|PubMed:12324459}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12324459}. Cell membrane {ECO:0000269|PubMed:11923287, ECO:0000269|PubMed:12324459}. Early endosome membrane {ECO:0000269|PubMed:11923287}. Note=Mainly cytosolic, association with membranes of the Golgi, endoplasmic and plasma membrane is stimulated by active RAC1 (PubMed:12324459). Association with early endosomes has not been confirmed (PubMed:11923287, PubMed:12324459). {ECO:0000269|PubMed:11923287, ECO:0000269|PubMed:12324459}.
uniprot
proteins