Nfil3
entrez
18030
canonical
uniprot
O08750
canonical
ensembl
ENSMUSG00000056749
resolver
ensp
ENSMUSP00000065363
resolver
ensp
ENSMUSP00000168193
resolver
ensp
ENSMUSP00000168202
resolver
enst
ENSMUST00000071065
resolver
genesymbol
Nfil3
resolver
genesymbol_syn
E4bp4
resolver
uniprot
Q3ULK2
resolver
uniprot
Q497U0
resolver
uniprot_entry
NFIL3_MOUSE
resolver
uniprot_sec
Q3ULK2
resolver
uniprot_sec
Q497U0
resolver
amino_acid_sequence
MQLRKMQTIKKEPAPLDPTSSSDKMLLLNSALAEVAEDLASGEDLLLNEGSMGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLENKLIALGEENATLKAELLSLKLKFGLISSTAYAQEIQKLSNSTAVYFQDYQTSKAAVSSFVDEHEPAMVAGSCISVIKHSPQSSLSDVSEVSSVEHTQESPAQGGCRSPENKFPVIKQEPVELESFAREAREERGTYSTSIYQSYMGSSFSTYSHSPPLLQVHGSTSNSPRTSEADEGVVGKSSDGEDEQQVPKGPIHSPVELQRVHATVVKVPEVNPSALPHKLRIKAKAMQVKVEALDSEFEGMQKLSSPADAIAKRHFDLEKHGTSGMAHSSLPPFSVQVTNIQDWSLKSEHWHHKELSSKTQSSFKTGVVEVKDGGYKVSEAENLYLKQGIANLSAEVVSLKRFIATQPISASDSR
uniprot
proteins
function
FUNCTION: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites (By similarity). Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells (By similarity). Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death. Represses the transcription of CYP2A5 (PubMed:30555544). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (PubMed:29653076). Required for the development of natural killer cell precursors (PubMed:32190943). {ECO:0000250|UniProtKB:Q16649, ECO:0000269|PubMed:11316793, ECO:0000269|PubMed:15087429, ECO:0000269|PubMed:17182630, ECO:0000269|PubMed:29653076, ECO:0000269|PubMed:30555544, ECO:0000269|PubMed:32190943, ECO:0000269|PubMed:9122243}.
uniprot
proteins
mass_dalton
50943
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
NFIL3 subfamily
uniprot
proteins
pubmed
11316793
uniprot
proteins
pubmed
12743120
uniprot
proteins
pubmed
15087429
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17182630
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17274955
uniprot
proteins
pubmed
29653076
uniprot
proteins
pubmed
30555544
uniprot
proteins
pubmed
32190943
uniprot
proteins
pubmed
9122243
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:11316793}.
uniprot
proteins