Ikzf3
entrez
22780
canonical
uniprot
O08900
canonical
ensembl
ENSMUSG00000018168
resolver
ensp
ENSMUSP00000099430
resolver
enst
ENSMUST00000103141
resolver
genesymbol
Ikzf3
resolver
genesymbol_syn
Zfpn1a3
resolver
genesymbol_syn
Znfn1a3
resolver
uniprot
B1AQE6
resolver
uniprot_entry
IKZF3_MOUSE
resolver
uniprot_sec
B1AQE6
resolver
amino_acid_sequence
MEDIQPTVELKSTEEQPLPTESPDALNDYSLPKPHEIENVDSREAPANEDEDAGEDSMKVKDEYSDRDENIMKPEPMGDAEESEMPYSYAREYSDYESIKLERHVPYDNSRPTGGKMNCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRAFLQNPDLGDAASVEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDANYNPGYMYEKENEMMQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPVISSVYPIALTRADMPNGAPQEMEKKRILLPEKILPSERGLSPNNSAQDSTDTDSNHEDRQHLYQQSHVVLPQARNGMPLLKEVPRSFELLKPPPICLRDSIKVINKEGEVMDVFRCDHCHVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRAMLK
uniprot
proteins
function
FUNCTION: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Binds to GGGAA. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. {ECO:0000269|PubMed:34155405, ECO:0000269|PubMed:9155026, ECO:0000269|PubMed:9806640}.
uniprot
proteins
mass_dalton
57967
uniprot
proteins
mutagenesis
MUTAGEN 158; /note="G->R: No effect on protein abundance. Changed DNA-binding transcription factor activity. Changed sequence-specific DNA binding. Binds novel and non-specific DNA motifs and acts as a dominant negative through its homodimerization and heterodimerization activities. Profound B cell development defects observed in homozygous or heterozygous animals. Impairs the differentiation of cells in adaptive immunity."; /evidence="ECO:0000269|PubMed:34155405
uniprot
proteins
protein_family
Ikaros C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34155405
uniprot
proteins
pubmed
9155026
uniprot
proteins
pubmed
9806640
uniprot
proteins
sequence_length
507
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9155026}. Cytoplasm {ECO:0000269|PubMed:9155026}.
uniprot
proteins