CCL21
entrez
6366
canonical
uniprot
O00585
canonical
ensembl
ENSG00000137077
resolver
ensp
ENSP00000259607
resolver
enst
ENST00000259607
resolver
genesymbol
CCL21
resolver
genesymbol_syn
SCYA21
resolver
hgnc
HGNC:10620
resolver
uniprot
Q6ICR7
resolver
uniprot_entry
CCL21_HUMAN
resolver
uniprot_sec
Q6ICR7
resolver
amino_acid_sequence
MAQSLALSLLILVLAFGIPRTQGSDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWVQQLMQHLDKTPSPQKPAQGCRKDRGASKTGKKGKGSKGCKRTERSQTPKGP
uniprot
proteins
function
FUNCTION: Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (PubMed:23341447). Binds to chemokine receptor CCR7 (PubMed:9507024). Does not bind to chemokine receptor CXCR3 (PubMed:10201891). Binds to G protein-coupled receptor GPR174 (By similarity). Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. {ECO:0000250|UniProtKB:P84444, ECO:0000269|PubMed:10201891, ECO:0000269|PubMed:23341447, ECO:0000269|PubMed:9507024}.
uniprot
proteins
mass_dalton
14646
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
10201891
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14978162
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22221265
uniprot
proteins
pubmed
23341447
uniprot
proteins
pubmed
27044744
uniprot
proteins
pubmed
9235955
uniprot
proteins
pubmed
9257816
uniprot
proteins
pubmed
9300671
uniprot
proteins
pubmed
9419363
uniprot
proteins
pubmed
9507024
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins