Gpr34
entrez
23890
canonical
uniprot
Q9R1K6
canonical
ensembl
ENSMUSG00000040229
resolver
ensp
ENSMUSP00000042715
resolver
ensp
ENSMUSP00000094236
resolver
ensp
ENSMUSP00000324236
resolver
ensp
ENSMUSP00000324238
resolver
enst
ENSMUST00000041708
resolver
enst
ENSMUST00000096492
resolver
genesymbol
Gpr34
resolver
genesymbol_syn
GPR34
resolver
uniprot
Q3YL73
resolver
uniprot_entry
GPR34_MOUSE
resolver
uniprot_entry
Q3YL73_MOUSE
resolver
amino_acid_sequence
MTTTSVDSWLCSSHGMHFITNYSDQASQNFSGVPNVTSCPMDEKLLSTVLTTFYSVIFLVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAVADLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQQRRAITTKQSIYVCCIVWTVALAGFLTMIILTLKKGGHNSTMCFHYRDRHNAKGEAIFNFVLVVMFWLIFLLIILSYIKIGKNLLRISKRRSKFPNSGKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNVSSCYWKEIIHKTNEIMLVFSSFNSCLDPVMYFLMSSNIRKIMCQLLFRRFQSEASRSESTSEFKPGHSLHDLSVTVKMPQYSTKGN
uniprot
proteins
function
FUNCTION: G protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed:21097509, PubMed:26851221, PubMed:34107271). Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils. Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production (PubMed:34107271). Plays an important role in microglial function, controlling morphology and phagocytosis (PubMed:25142016). {ECO:0000269|PubMed:21097509, ECO:0000269|PubMed:25142016, ECO:0000269|PubMed:26851221, ECO:0000269|PubMed:34107271}.
uniprot
proteins
mass_dalton
43173
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10395919
uniprot
proteins
pubmed
21097509
uniprot
proteins
pubmed
25142016
uniprot
proteins
pubmed
26851221
uniprot
proteins
pubmed
34107271
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9UPC5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UPC5}.
uniprot
proteins
transmembrane_region
TRANSMEM 55..75; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 122..142; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 210..230; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 263..283; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 304..324; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins