Tufm
entrez
293481
canonical
uniprot
P85834
canonical
ensembl
ENSRNOG00000018604
resolver
ensembl
ENSRNOG00055031153
resolver
ensembl
ENSRNOG00060029136
resolver
ensembl
ENSRNOG00065016529
resolver
ensp
ENSRNOP00000084136
resolver
ensp
ENSRNOP00055044694
resolver
ensp
ENSRNOP00060042092
resolver
ensp
ENSRNOP00065021670
resolver
enst
ENSRNOT00000109633
resolver
enst
ENSRNOT00055054012
resolver
enst
ENSRNOT00060050579
resolver
enst
ENSRNOT00065027543
resolver
genesymbol
Tufm
resolver
uniprot_entry
EFTU_RAT
resolver
amino_acid_sequence
MAAATLLRATPRFSGLCASPTPFLQGRLRPLKAPASPFLCRGLAVEAKKTYVRDKPHVNVGTIGHVDHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEERARGITINAAHVEYSTAARHYAHTDCPGHADYVKNMITGTAPLDGCILVVAANDGPMPQTREHLLLAKQIGVEHVVVYVNKADAVQDSEMVELVELEIRELLTEFGYKGEETPVIVGSALCALEQRDPELGVKSVQKLLDAVDTYIPVPTRDLEKPFLLPVESVYSIPGRGTVVTGTLERGILKKGDECELLGHNKNIRTVVTGIEMFHKSLERAEAGDNLGALVRGLKREDLRRGLVMVKPGSIQPHQKVEAQVYILSKEEGGRHKPFVSHFMPVMFSLTWDMACRVILPPGKELAMPGEDLKLSLILRQPMILEKGQRFTLRDGNKTIGTGLVTDVPAMTEEDKNIKWS
uniprot
proteins
ec_number
3.6.5.3
uniprot
proteins
function
FUNCTION: GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Participates in mitochondrial translation (By similarity). Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy (By similarity). {ECO:0000250|UniProtKB:P49410, ECO:0000250|UniProtKB:P49411}.
uniprot
proteins
mass_dalton
49522
uniprot
proteins
pathway_participation
PATHWAY: Protein biosynthesis; polypeptide chain elongation. {ECO:0000250|UniProtKB:P49410}.
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
EF-Tu/EF-1A subfamily
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
19343716
uniprot
proteins
sequence_length
452
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P49411}.
uniprot
proteins