Castor1
entrez
360969
canonical
uniprot
Q5BJZ0
canonical
ensembl
ENSRNOG00000006740
resolver
ensembl
ENSRNOG00055029847
resolver
ensembl
ENSRNOG00060024842
resolver
ensembl
ENSRNOG00065029749
resolver
ensp
ENSRNOP00000009150
resolver
ensp
ENSRNOP00055042650
resolver
ensp
ENSRNOP00060035578
resolver
ensp
ENSRNOP00065042325
resolver
enst
ENSRNOT00000009150
resolver
enst
ENSRNOT00055051712
resolver
enst
ENSRNOT00060042972
resolver
enst
ENSRNOT00065051390
resolver
genesymbol
Castor1
resolver
genesymbol_syn
Gatsl3
resolver
uniprot_entry
CAST1_RAT
resolver
amino_acid_sequence
MELHILEHRVRVLSLARPGLWLYTHPLIKLLFLPSRSRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVMNVSHSGSVVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAREFQIYREVGGEPVPVTGDDSSNGFPQAQHGPSPTVHPIQSPQNRFCVLTLDPETLPAVATTLIDVLFYSHSVPKEAASGGPESTSIPFFAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAVDVSAYYISTFNFDHALVPEDEISCVIDILQRRQEGLASKDP
uniprot
proteins
function
FUNCTION: Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. {ECO:0000250|UniProtKB:Q8WTX7}.
uniprot
proteins
mass_dalton
36476
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-14 by AKT1, promoting the interaction between CASTOR1 and RNF167. {ECO:0000250|UniProtKB:Q8WTX7}.; PTM: Ubiquitinated by RNF167 via 'Lys-29'-polyubiquitination, leading to its degradation, releasing the GATOR2 complex. Ubiquitination by RNF167 is promoted by phosphorylation at Ser-14 by AKT1. {ECO:0000250|UniProtKB:Q8WTX7}.
uniprot
proteins
protein_family
GATS family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8WTX7}.
uniprot
proteins