GRIK1
entrez
2897
canonical
uniprot
P39086
canonical
ensembl
ENSG00000171189
resolver
ensp
ENSP00000327687
resolver
ensp
ENSP00000373777
resolver
ensp
ENSP00000382791
resolver
ensp
ENSP00000382793
resolver
ensp
ENSP00000382797
resolver
ensp
ENSP00000382798
resolver
enst
ENST00000327783
resolver
enst
ENST00000399909
resolver
enst
ENST00000399913
resolver
enst
ENST00000399914
resolver
genesymbol
GRIK1
resolver
genesymbol_syn
GLUR5
resolver
hgnc
HGNC:4579
resolver
uniprot
B7Z256
resolver
uniprot
B7Z3V7
resolver
uniprot
E7ENK3
resolver
uniprot
E7EPY9
resolver
uniprot
E7EPZ0
resolver
uniprot
E9PD61
resolver
uniprot
Q13001
resolver
uniprot
Q86SU9
resolver
uniprot_entry
B7Z256_HUMAN
resolver
uniprot_entry
B7Z3V7_HUMAN
resolver
uniprot_entry
E7ENK3_HUMAN
resolver
uniprot_entry
E7EPY9_HUMAN
resolver
uniprot_entry
E7EPZ0_HUMAN
resolver
uniprot_entry
E9PD61_HUMAN
resolver
uniprot_entry
GRIK1_HUMAN
resolver
uniprot_sec
Q13001
resolver
uniprot_sec
Q86SU9
resolver
amino_acid_sequence
MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQAFCFFYGLQCKQTHPTNSTSGTTLSTDLECGKLIREERGIRKQSSVHTV
uniprot
proteins
function
FUNCTION: Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. {ECO:0000269|PubMed:8730589}.; FUNCTION: [Isoform 2]: Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. {ECO:0000269|PubMed:8589992}.
uniprot
proteins
mass_dalton
103981
uniprot
proteins
protein_family
GRIK1 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
11702055
uniprot
proteins
pubmed
21893069
uniprot
proteins
pubmed
7696618
uniprot
proteins
pubmed
8260617
uniprot
proteins
pubmed
8589992
uniprot
proteins
pubmed
8730589
uniprot
proteins
sequence_length
918
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P22756}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P22756}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 577..597; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 654..674; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 835..855; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins