P40694
uniprot
P40694
canonical
amino_acid_sequence
MASSTVESFVAQQLQLLELERDAEVEERRSWQEHSSLRELQSRGVCLLKLQVSSQRTGLYGQRLVTFEPRKFGPAVVLPSNSFTSGDIVGLYDTNENSQLATGVLTRITQKSVTVAFDESHDLQLNLDRENTYRLLKLANDVTYKRLKKALMTLKKYHSGPASSLIDILLGSSTPSPAMEIPPLSFYNTTLDLSQKEAVSFALAQKELAIIHGPPGTGKTTTVVEIILQAVKQGLKVLCCAPSNIAVDNLVERLALCKKRILRLGHPARLLESVQHHSLDAVLARSDNAQIVADIRRDIDQVFGKNKKTQDKREKGNFRSEIKLLRKELKEREEAAIVQSLTAADVVLATNTGASSDGPLKLLPEDYFDVVVVDECAQALEASCWIPLLKAPKCILAGDHRQLPPTTVSHRAALAGLSRSLMERLAEKHGAGVVRMLTVQYRMHQAIMCWASEAMYHGQFTSHPSVAGHLLKDLPGVTDTEETRVPLLLIDTAGCGLLELEEEDSQSKGNPGEVRLVTLHIQALVDAGVQAGDIAVIAPYNLQVDLLRQSLSNKHPELEIKSVDGFQGREKEAVLLTFVRSNRKGEVGFLAEDRRINVAVTRARRHVAVICDSHTVNNHAFLETLVDYFTEHGEVRTAFEYLDDIVPENYTHEGSQGHSRVPKPKCPSTSIRKPASDQESGQETRAAPRHGRRKPSEKPPGSHVQSQHSSSANGSDRTGGPDRTEHFRATIEEFVASKESQLEFPTSLSSHDRLRVHQLAEEFGLRHDSTGEGKARHITVSRRSPASSGSVAPQPSSPPSPAQAEPEPRAEEPVTVVQAHCPVQLDLKALHLERLQRQQSSQAQTAKGQPGGDSRPQKASQKKKKKEPKGPVMALPCEEDFDALVSAVVKADNTCSFSKCSVSTTTLGQFCMHCSHRYYLSHHLPEIHGCGEKARAHARQRISREGVLYAGSGTKDRALDPAKRAQLQRRLDKKLGELSSQRTSRKKEKERGT
uniprot
proteins
ec_number
5.6.2.3
uniprot
proteins
ec_number
5.6.2.5
uniprot
proteins
function
FUNCTION: 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (PubMed:22965130, PubMed:8493094). Specific to 5'-phosphorylated single-stranded guanine-rich sequences (PubMed:8493094). May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (PubMed:19158098, PubMed:19299493). May play a role in regulation of transcription (By similarity). Interacts with tRNA-Tyr (PubMed:19299493). {ECO:0000250|UniProtKB:Q9EQN5, ECO:0000269|PubMed:19158098, ECO:0000269|PubMed:19299493, ECO:0000269|PubMed:22965130, ECO:0000269|PubMed:8493094}.
uniprot
proteins
mass_dalton
109466
uniprot
proteins
protein_family
DNA2/NAM7 helicase family
uniprot
proteins
pubmed
19158098
uniprot
proteins
pubmed
19299493
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22965130
uniprot
proteins
pubmed
8493094
uniprot
proteins
sequence_length
993
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P38935}. Cytoplasm {ECO:0000269|PubMed:19158098}. Cell projection, axon {ECO:0000269|PubMed:19158098}.
uniprot
proteins