Ptch2
entrez
19207
canonical
uniprot
O35595
canonical
ensembl
ENSMUSG00000028681
resolver
ensp
ENSMUSP00000030443
resolver
enst
ENSMUST00000030443
resolver
genesymbol
Ptch2
resolver
uniprot
A2AE82
resolver
uniprot
Q546T0
resolver
uniprot_entry
PTC2_MOUSE
resolver
uniprot_sec
A2AE82
resolver
uniprot_sec
Q546T0
resolver
amino_acid_sequence
MVRPLSLGELPPSYTPPARSSAPHILAGSLQAPLWLRAYFQGLLFSLGCRIQKHCGKVLFLGLVAFGALALGLRVAVIETDLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTAHQEGGNVLTPEALDLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPQQLLEELGPFASLEGFRELLDKAQVGQAYVGRPCLDPDDPHCPPSAPNRHSRQAPNVAQELSGGCHGFSHKFMHWQEELLLGGTARDLQGQLLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASMVLQAWQRRFVQLAQEALPANASQQIHAFSSTTLDDILRAFSEVSTTRVVGGYLLMLAYACVTMLRWDCAQSQGAVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDIFLLAHAFTKAPPDTPLPERMGECLRSTGTSVALTSVNNMVAFFMAALVPIPALRAFSLQAAIVVGCNFAAVMLVFPAILSLDLRRRHRQRLDVLCCFSSPCSAQVIQMLPQELGDRAVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLLSPASDPLGSELYSPGGSTRDLLSQEEGTGPQAACRPLLCAHWTLAHFARYQFAPLLLQTRAKALVLLFFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRSWLQGIQAAFDQDWASGRITCHSYRNGSEDGALAYKLLIQTGNAQEPLDFSQLTTRKLVDKEGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGENLRIPAAQPLEFAQFPFLLHGLQKTADFVEAIEGARAACTEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLSPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASIGIGVEFTVHVALGFLTSHGSRNLRAASALEQTFAPVTDGAVSTLLGLLMLAGSNFDFIIRYFFVVLTVLTLLGLLHGLLLLPVLLSILGPPPQVVQVYKESPQTLNSAAPQRGGLRWDRPPTLPQSFARVTTSMTVALHPPPLPGAYVHPASEEPT
uniprot
proteins
function
FUNCTION: Negative regulator of the smoothened signaling pathway, which acts as a receptor for hedgehog (SHH, IHH and DHH) morphogens (PubMed:25085974, PubMed:27552050). In absence of hedgehog, acts as an inhibitor of smoothened protein (SMO) by preventing SMO access to cholesterol: mechanistically, acts as a cholesterol transporter, which depeletes cholesterol from the outer leaflet of plasma membrane, thereby preventing cholesterol-binding to the extracellular CRD region of SMO (By similarity). Hedgehog-binding inhibits PTCH1 cholesterol transporter activity, promoting SMO activation by cholesterol and transduction of the smoothened signaling pathway (By similarity). Molecular mechanism governing cholesterol transport are still unclear: may move cholesterol from the outer to the inner leaflet of the membrane in exchange for potassium or sodium ion export in the opposite direction (By similarity). In contrast to PTCH1 ortholog, PTCH2 is not essential for viability and plays a more limited role (PubMed:16914743). Plays a role in epidermal homeostasis in mature skin (PubMed:16914743). {ECO:0000250|UniProtKB:Q61115, ECO:0000269|PubMed:16914743, ECO:0000269|PubMed:25085974, ECO:0000269|PubMed:27552050}.
uniprot
proteins
mass_dalton
128586
uniprot
proteins
protein_family
Patched family
uniprot
proteins
pubmed
12438747
uniprot
proteins
pubmed
16914743
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25085974
uniprot
proteins
pubmed
27552050
uniprot
proteins
pubmed
9237688
uniprot
proteins
pubmed
9462734
uniprot
proteins
sequence_length
1182
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q61115}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q61115}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q61115}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q61115}. Note=Localizes to primary cilium and prevents cilium localization of SMO. Delocalizes from primary cilium following hedgehog-binding. {ECO:0000250|UniProtKB:Q61115}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..78; /note="Helical; Name=TM1"; /evidence="ECO:0000255"; TRANSMEM 395..414; /note="Helical; Name=TM2"; /evidence="ECO:0000255"; TRANSMEM 429..449; /note="Helical; Name=TM3"; /evidence="ECO:0000255"; TRANSMEM 458..478; /note="Helical; Name=TM4"; /evidence="ECO:0000255"; TRANSMEM 502..522; /note="Helical; Name=TM5"; /evidence="ECO:0000255"; TRANSMEM 532..552; /note="Helical; Name=TM6"; /evidence="ECO:0000255"; TRANSMEM 687..707; /note="Helical; Name=TM7"; /evidence="ECO:0000255"; TRANSMEM 964..984; /note="Helical; Name=TM8"; /evidence="ECO:0000255"; TRANSMEM 992..1012; /note="Helical; Name=TM9"; /evidence="ECO:0000255"; TRANSMEM 1014..1034; /note="Helical; Name=TM10"; /evidence="ECO:0000255"; TRANSMEM 1065..1085; /note="Helical; Name=TM11"; /evidence="ECO:0000255"; TRANSMEM 1087..1107; /note="Helical; Name=TM12"; /evidence="ECO:0000255
uniprot
proteins