MAPK8IP1
entrez
9479
canonical
uniprot
Q9UQF2
canonical
ensembl
ENSG00000121653
resolver
ensp
ENSP00000241014
resolver
enst
ENST00000241014
resolver
genesymbol
MAPK8IP1
resolver
genesymbol_syn
IB1
resolver
genesymbol_syn
JIP1
resolver
genesymbol_syn
PRKM8IP
resolver
hgnc
HGNC:6882
resolver
uniprot
D3DQP4
resolver
uniprot
O43407
resolver
uniprot
Q6NUQ9
resolver
uniprot_entry
JIP1_HUMAN
resolver
uniprot_entry
Q6NUQ9_HUMAN
resolver
uniprot_sec
D3DQP4
resolver
uniprot_sec
O43407
resolver
amino_acid_sequence
MAERESGGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRPPRAGLLSAGGGGAGSRLQAEMLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAPTTDRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASVSSPYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCIINGEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE
uniprot
proteins
disease_involvement
DISEASE: Type 2 diabetes mellitus (T2D) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269|PubMed:10700186}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. {ECO:0000250|UniProtKB:Q9WVI9}.
uniprot
proteins
mass_dalton
77524
uniprot
proteins
mutagenesis
MUTAGEN 160; /note="R->G: Abolishes MAPK9 interaction."; /evidence="ECO:0000269|PubMed:12756254"; MUTAGEN 161; /note="P->G: Abolishes MAPK9 interaction."; /evidence="ECO:0000269|PubMed:12756254"; MUTAGEN 704; /note="P->A: No effect on KNS2 binding."; /evidence="ECO:0000269|PubMed:11238452"; MUTAGEN 709; /note="Y->A: Abolishes KNS2 binding."; /evidence="ECO:0000269|PubMed:11238452
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK8, MAPK9 and MAPK10. Phosphorylation on Thr-103 is also necessary for the dissociation and activation of MAP3K12. Phosphorylated by isoform 1 and isoform 2 of VRK2. Hyperphosphorylated during mitosis following activation of stress-activated and MAP kinases. {ECO:0000269|PubMed:12756254}.; PTM: Ubiquitinated. Two preliminary events are required to prime for ubiquitination; phosphorylation and an increased in intracellular calcium concentration. Then, the calcium influx initiates ubiquitination and degradation by the ubiquitin-proteasome pathway.
uniprot
proteins
protein_family
JIP scaffold family
uniprot
proteins
pubmed
10574993
uniprot
proteins
pubmed
10700186
uniprot
proteins
pubmed
11147798
uniprot
proteins
pubmed
11238452
uniprot
proteins
pubmed
11726277
uniprot
proteins
pubmed
11912189
uniprot
proteins
pubmed
12756254
uniprot
proteins
pubmed
12937412
uniprot
proteins
pubmed
14507925
uniprot
proteins
pubmed
16195223
uniprot
proteins
pubmed
17709393
uniprot
proteins
pubmed
18286207
uniprot
proteins
pubmed
9933567
uniprot
proteins
sequence_length
711
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum membrane. Mitochondrion membrane. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity). {ECO:0000250}.
uniprot
proteins