Ifi204
entrez
15951
canonical
uniprot
P0DOV2
canonical
ensembl
ENSMUSG00000073489
resolver
ensp
ENSMUSP00000106845
resolver
ensp
ENSMUSP00000273006
resolver
enst
ENSMUST00000111214
resolver
genesymbol
Ifi204
resolver
uniprot
B7ZNS3
resolver
uniprot
P15092
resolver
uniprot
Q08619
resolver
uniprot
Q3TM07
resolver
uniprot
Q3U776
resolver
uniprot
Q3U7F4
resolver
uniprot
Q3U7K5
resolver
uniprot
Q3UCH9
resolver
uniprot
Q8C4X3
resolver
uniprot
Q921V9
resolver
uniprot_entry
IFI4_MOUSE
resolver
uniprot_sec
B7ZNS3
resolver
uniprot_sec
P15092
resolver
uniprot_sec
Q08619
resolver
uniprot_sec
Q3TM07
resolver
uniprot_sec
Q3U776
resolver
uniprot_sec
Q3U7F4
resolver
uniprot_sec
Q3U7K5
resolver
uniprot_sec
Q3UCH9
resolver
uniprot_sec
Q8C4X3
resolver
uniprot_sec
Q921V9
resolver
amino_acid_sequence
MVNEYKRIVLLRGLECINKHYFSLFKSLLARDLNLERDNQEQYTTIQIANMMEEKFPADSGLGKLIAFCEEVPALRKRAEILKKERSEVTGETSLEKNGQEAGPATPTSTTSHMLASERGETSATQEETSTAQAGTSTAQARTSTAQAGTSTAQKRKIMREEETGVKKSKAAKEPDQPPCCEEPTARCQSPILHSSSSASSNIPSAKNQKSQPQNQNIPRGAVLHSEPLTVMVLTATDPFEYESPEHEVKNMLHATVATVSQYFHVKVFNINLKEKFTKKNFIIISNYFESKGILEINETSSVLEAAPDQMIEVPNSIIRNANASPKICDIQKGTSGAVFYGVFTLHKKTVNRKNTIYEIKDGSGSIEVVGSGKWHNINCKEGDKLHLFCFHLKTIDRQPKLVCGEHSFIKISKRGNVPKEPAKEEDHHHGPKQVMVLKVTEPFTYDLKEDKRMFHATVATETEFFRVKVFDTALKSKFIPRNIIAISDYFGCNGFLEIYRASCVSDVNVNPTMVISNTLRQRANATPKISYLFSQARGTFVSGEYLVNKKTERNKFIYYGIGDDTGKMEVVVYGRLTNVRCEPGSKLRLVCFELTSTEDGWQLRSVRHSYMQVINARK
uniprot
proteins
function
FUNCTION: Interferon-stimulated protein that plays a role in several biological processes including cell differentiation, autophagy and innate immunity (PubMed:16244109, PubMed:25710914, PubMed:30936875). Cooperates with CGAS to sense dsDNA and activates the STING-dependent type I IFN pathway (PubMed:25710914, PubMed:33619523). Mechanistically, gets acetylated upon bacterial infection and then translocates from nucleus into cytoplasm to recruit STING for activation of TBK1-dependent IRF3 nuclear translocation and IFN-beta release (PubMed:28529930). Inhibits the transcription of ribosomal RNA. May inhibit DNA binding by UBTF. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Acts as a coactivator of RUNX2 during osteogenesis. May be involved in macrophage differentiation. Enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation. {ECO:0000269|PubMed:10329630, ECO:0000269|PubMed:11940648, ECO:0000269|PubMed:15557274, ECO:0000269|PubMed:16244109, ECO:0000269|PubMed:16458891, ECO:0000269|PubMed:16556595, ECO:0000269|PubMed:16556596, ECO:0000269|PubMed:25710914, ECO:0000269|PubMed:28529930, ECO:0000269|PubMed:30936875, ECO:0000269|PubMed:33619523}.
uniprot
proteins
mass_dalton
69438
uniprot
proteins
post_translational_modification
PTM: Acetylated upon bacterial infection, leading to translocation from nucleus to cytoplasm and subsequent recruitment of STING to activate IFN-beta production. {ECO:0000269|PubMed:28529930}.
uniprot
proteins
protein_family
HIN-200 family
uniprot
proteins
pubmed
10329630
uniprot
proteins
pubmed
11940648
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15557274
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16244109
uniprot
proteins
pubmed
16458891
uniprot
proteins
pubmed
16556595
uniprot
proteins
pubmed
16556596
uniprot
proteins
pubmed
2477366
uniprot
proteins
pubmed
25710914
uniprot
proteins
pubmed
28529930
uniprot
proteins
pubmed
30936875
uniprot
proteins
pubmed
33619523
uniprot
proteins
sequence_length
619
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28529930}. Nucleus, nucleolus. Cytoplasm {ECO:0000269|PubMed:28529930}. Note=Nuclear in proliferating cells, translocates to cytosol during cell differentiation or bacterial infection. {ECO:0000269|PubMed:28529930}.
uniprot
proteins