RILP
entrez
83547
canonical
uniprot
Q96NA2
canonical
ensembl
ENSG00000167705
resolver
ensembl
ENSG00000274145
resolver
ensp
ENSP00000301336
resolver
genesymbol
RILP
resolver
hgnc
HGNC:30266
resolver
uniprot
B2RBQ8
resolver
uniprot
Q71RE6
resolver
uniprot
Q9BSL3
resolver
uniprot
Q9BYS3
resolver
uniprot_entry
RILP_HUMAN
resolver
uniprot_sec
B2RBQ8
resolver
uniprot_sec
Q71RE6
resolver
uniprot_sec
Q9BSL3
resolver
uniprot_sec
Q9BYS3
resolver
amino_acid_sequence
MEPRRAAPGVPGWGSREAAGSASAAELVYHLAGALGTELQDLARRFGPEAAAGLVPLVVRALELLEQAAVGPAPDSLQVSAQPAEQELRRLREENERLRRELRAGPQEERALLRQLKEVTDRQRDELRAHNRDLRQRGQETEALQEQLQRLLLVNAELRHKLAAMQTQLRAAQDRERERQQPGEAATPQAKERARGQAGRPGHQHGQEPEWATAGAGAPGNPEDPAEAAQQLGRPSEAGQCRFSREEFEQILQERNELKAKVFLLKEELAYFQRELLTDHRVPGLLLEAMKVAVRKQRKKIKAKMLGTPEEAESSEDEAGPWILLSDDKGDHPPPPESKIQSFFGLWYRGKAESSEDETSSPAPSKLGGEEEAQPQSPAPDPPCSALHEHLCLGASAAPEA
uniprot
proteins
function
FUNCTION: Rab effector playing a role in late endocytic transport to degradative compartments (PubMed:11179213, PubMed:11696325, PubMed:12944476, PubMed:14668488, PubMed:27113757). Involved in the regulation of lysosomal morphology and distribution (PubMed:14668488, PubMed:27113757). Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments (PubMed:11179213, PubMed:11696325). Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes (PubMed:12944476). {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:11696325, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14668488, ECO:0000269|PubMed:27113757}.
uniprot
proteins
mass_dalton
44200
uniprot
proteins
mutagenesis
MUTAGEN 248; /note="F->A: Strongly reduces dimerization and localization to late endosomal/lysosomal compartments."; /evidence="ECO:0000269|PubMed:15933719"; MUTAGEN 251; /note="I->A: Abolishes dimerization, interaction with RAB7A and localization to late endosomal/lysosomal compartments."; /evidence="ECO:0000269|PubMed:15933719"; MUTAGEN 252; /note="L->A: Abolishes interaction with RAB7A and localization to late endosomal/lysosomal compartments."; /evidence="ECO:0000269|PubMed:15933719"; MUTAGEN 255; /note="R->A: Abolishes dimerization, interaction with RAB7A and localization to late endosomal/lysosomal compartments."; /evidence="ECO:0000269|PubMed:15933719"; MUTAGEN 258; /note="L->A: Reduces dimerization, interaction with RAB7A and localization to late endosomal/lysosomal compartments."; /evidence="ECO:0000269|PubMed:15933719"; MUTAGEN 304; /note="K->A: Abolishes interaction with RAB7A and localization to late endosomal/lysosomal compartments."; /evidence="ECO:0000269|PubMed:15933719"; MUTAGEN 305; /note="M->A: Abolishes interaction with RAB7A and localization to late endosomal/lysosomal compartments."; /evidence="ECO:0000269|PubMed:15933719"; MUTAGEN 306; /note="L->A: Abolishes interaction with RAB7A and localization to late endosomal/lysosomal compartments."; /evidence="ECO:0000269|PubMed:15933719
uniprot
proteins
pubmed
11179213
uniprot
proteins
pubmed
11520070
uniprot
proteins
pubmed
11696325
uniprot
proteins
pubmed
12475955
uniprot
proteins
pubmed
12944476
uniprot
proteins
pubmed
14668488
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
15933719
uniprot
proteins
pubmed
15996637
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
22261744
uniprot
proteins
pubmed
22431521
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27113757
uniprot
proteins
sequence_length
401
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476}. Lysosome membrane {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14668488}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:12944476}. Note=Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes. {ECO:0000269|PubMed:12944476}.
uniprot
proteins