NPAT
entrez
4863
canonical
uniprot
Q14207
canonical
ensembl
ENSG00000149308
resolver
ensp
ENSP00000278612
resolver
ensp
ENSP00000520908
resolver
ensp
ENSP00000605849
resolver
enst
ENST00000278612
resolver
enst
ENST00000850623
resolver
genesymbol
NPAT
resolver
genesymbol_syn
CAND3
resolver
genesymbol_syn
E14
resolver
hgnc
HGNC:7896
resolver
uniprot
A8K1V5
resolver
uniprot
A8K6M2
resolver
uniprot
Q13632
resolver
uniprot
Q14967
resolver
uniprot
Q16580
resolver
uniprot
Q86W55
resolver
uniprot
Q8IWE9
resolver
uniprot_entry
NPAT_HUMAN
resolver
uniprot_sec
A8K1V5
resolver
uniprot_sec
A8K6M2
resolver
uniprot_sec
Q13632
resolver
uniprot_sec
Q14967
resolver
uniprot_sec
Q16580
resolver
uniprot_sec
Q86W55
resolver
uniprot_sec
Q8IWE9
resolver
amino_acid_sequence
MLLPSDVARLVLGYLQQENLISTCQTFILESSDLKEYAEHCTDEGFIPACLLSLFGKNLTTILNEYVAMKTKETSNNVPAIMSSLWKKLDHTLSQIRSMQSSPRFAGSQRARTRTGIAEIKRQRKLASQTAPASAELLTLPYLSGQFTTPPSTGTQVTRPSGQISDPSRSYFVVVNHSQSQDTVTTGEALNVIPGAQEKKAHASLMSPGRRKSESQRKSTTLSGPHSTIRNFQDPNAFAVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDNNIAQVPKQTDNNPTEPETSIDEFLGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNISQSISSQPMESNPSIVLADETNLAVKGSFETEESDGQSGQPAFCTSYQNDDPLNALKNSNNHDVLRQEDQENFSQISTSIQKKAFKTAVPTEQKCDIDITFESVPNLNDFNQRGNSNAECNPHCAELYTNQMSTETEMAIGIEKNSLSSNVPSESQLQPDQPDIPITSFVSLGCEANNENLILSGKSSQLLSQDTSLTGKPSKKSQFCENSNDTVKLKINFHGSKSSDSSEVHKSKIEINVLEPVMSQLSNCQDNSCLQSEILPVSVESSHLNVSGQVEIHLGDSLSSTKQPSNDSASVELNHTENEAQASKSENSQEPSSSVKEENTIFLSLGGNANCEKVALTPPEGTPVENSHSLPPESVCSSVGDSHPESQNTDDKPSSNNSAEIDASNIVSLKVIISDDPFVSSDTELTSAVSSINGENLPTIILSSPTKSPTKNAELVKCLSSEETVGAVVYAEVGDSASMEQSLLTFKSEDSAVNNTQNEDGIAFSANVTPCVSKDGGYIQLMPATSTAFGNSNNILIATCVTDPTALGTSVSQSNVVVLPGNSAPMTAQPLPPQLQTPPRSNSVFAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNNFSTPPRQVLHMPLTAPVCNRSIPQFPVPPKSQKAQGLRNKPCIGKQVNNLVDSSGHSVGCHAQKTEVSDKSIATDLGKKSEETTVPFPEESIVPAAKPCHRRVLCFDSTTAPVANTQGPNHKMVSQNKERNAVSFPNLDSPNVSSTLKPPSNNAIKREKEKPPLPKILSKSESAISRHTTIRETQSEKKVSPTEIVLESFHKATANKENELCSDVERQKNPENSKLSIGQQNGGLRSEKSIASLQEMTKKQGTSSNNKNVLSVGTAVKDLKQEQTKSASSLITTEMLQDIQRHSSVSRLADSSDLPVPRTPGSGAGEKHKEEPIDIIKAPSSRRFSEDSSTSKVMVPPVTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSATPLKDNTQQFRASSRSTTKKRKIEELDERERNSRPSSKNLTNSSIPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE
uniprot
proteins
function
FUNCTION: Transcription regulator required for progression through the G1 and S phases of the cell cycle and for S phase entry (PubMed:12665581, PubMed:15555599, PubMed:9472014). Acts as a key transcription regulator of histones (PubMed:10995386, PubMed:10995387, PubMed:12724424, PubMed:14585971, PubMed:14612403, PubMed:15988025, PubMed:16131487, PubMed:17163457, PubMed:25339177, PubMed:40516528, PubMed:40516529). Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with GON4L and MIZF (PubMed:10995386, PubMed:10995387, PubMed:12724424, PubMed:14585971, PubMed:14612403, PubMed:15988025, PubMed:16131487, PubMed:17163457, PubMed:25339177). Together with CRAMP1, binds to the promoters of H1 genes (H1-2, H1-3, H1-4, H1-5 and H1-10/H1x), driving their transcription (PubMed:40516528, PubMed:40516529). Also positively regulates the ATM, MIZF and PRKDC promoters (PubMed:17826007, PubMed:17974976, PubMed:8743993, PubMed:8923007). Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters (PubMed:17967892). {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:25339177, ECO:0000269|PubMed:40516528, ECO:0000269|PubMed:40516529, ECO:0000269|PubMed:8743993, ECO:0000269|PubMed:8923007, ECO:0000269|PubMed:9472014}.
uniprot
proteins
mass_dalton
154290
uniprot
proteins
mutagenesis
MUTAGEN 7; /note="V->A: Impairs activation of histone gene transcription; when associated with A-10; A-11; A-15 and A-18."; /evidence="ECO:0000269|PubMed:12724424"; MUTAGEN 10; /note="L->A: Impairs activation of histone gene transcription; when associated with A-7; A-11; A-15 and A-18."; /evidence="ECO:0000269|PubMed:12724424"; MUTAGEN 11; /note="V->A: Impairs activation of histone gene transcription; when associated with A-7; A-10; A-15 and A-18."; /evidence="ECO:0000269|PubMed:12724424"; MUTAGEN 15; /note="L->A: Impairs activation of histone gene transcription; when associated with A-7; A-10; A-11 and A-18."; /evidence="ECO:0000269|PubMed:12724424"; MUTAGEN 18; /note="E->A: Impairs activation of histone gene transcription; when associated with A-7; A-10; A-11 and A-15."; /evidence="ECO:0000269|PubMed:12724424"; MUTAGEN 27; /note="F->A: Impairs activation of histone gene transcription; when associated with A-30."; /evidence="ECO:0000269|PubMed:12724424"; MUTAGEN 30; /note="E->A: Impairs activation of histone gene transcription; when associated with A-27."; /evidence="ECO:0000269|PubMed:12724424"; MUTAGEN 331..333; /note="LFD->AAA: Impairs activation of histone gene transcription. Impairs interaction with BZW1, RUVBL1, RUVBL2 and TRRAP."; /evidence="ECO:0000269|PubMed:17967892"; MUTAGEN 775; /note="S->A: Impairs activation of histone gene transcription; when associated with A-779; A-1100; A-1270 and A-1350."; /evidence="ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:17163457"; MUTAGEN 779; /note="S->A: Impairs activation of histone gene transcription; when associated with A-775; A-1100; A-1270 and A-1350."; /evidence="ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:17163457"; MUTAGEN 1100; /note="S->A: Impairs activation of histone gene transcription; when associated with A-775; A-779; A-1270 and A-1350."; /evidence="ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:17163457"; MUTAGEN 1270; /note="T->A: Impairs activation of histone gene transcription; when associated with A-775; A-779; A-1100 and A-1350."; /evidence="ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:17163457"; MUTAGEN 1350; /note="T->A: Impairs activation of histone gene transcription; when associated with A-775; A-779; A-1100 and A-1270."; /evidence="ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:17163457
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-775, Ser-779, Ser-1100, Thr-1270 and Thr-1350 by CCNE1/CDK2 at G1-S transition and until prophase, which promotes association with histone gene clusters and stimulates activation of histone transcription. Also phosphorylated by CCNA1/CDK2 in vitro. {ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:14976556, ECO:0000269|PubMed:9472014}.
uniprot
proteins
protein_family
NPAT family
uniprot
proteins
pubmed
10995386
uniprot
proteins
pubmed
10995387
uniprot
proteins
pubmed
12032824
uniprot
proteins
pubmed
12665581
uniprot
proteins
pubmed
12724424
uniprot
proteins
pubmed
12887926
uniprot
proteins
pubmed
14585971
uniprot
proteins
pubmed
14612403
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14976556
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15555599
uniprot
proteins
pubmed
15988025
uniprot
proteins
pubmed
16131487
uniprot
proteins
pubmed
16972248
uniprot
proteins
pubmed
17003125
uniprot
proteins
pubmed
17068332
uniprot
proteins
pubmed
17096384
uniprot
proteins
pubmed
17163457
uniprot
proteins
pubmed
17520687
uniprot
proteins
pubmed
17826007
uniprot
proteins
pubmed
17967892
uniprot
proteins
pubmed
17974976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25339177
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
40516528
uniprot
proteins
pubmed
40516529
uniprot
proteins
pubmed
8743993
uniprot
proteins
pubmed
8923007
uniprot
proteins
pubmed
9060412
uniprot
proteins
pubmed
9205109
uniprot
proteins
pubmed
9472014
uniprot
proteins
sequence_length
1427
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:17068332}. Nucleus, Cajal body {ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:17068332}. Chromosome {ECO:0000269|PubMed:40516529}. Note=Localizes to histone locus bodies (HLB) (PubMed:25339177, PubMed:40516529). Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases (PubMed:15988025, PubMed:17068332). Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 specifically during S and G2 phases (PubMed:15988025, PubMed:17068332). {ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:17068332, ECO:0000269|PubMed:25339177, ECO:0000269|PubMed:40516529}.
uniprot
proteins