Syngr2
entrez
89815
canonical
uniprot
O54980
canonical
ensembl
ENSRNOG00000050547
resolver
ensp
ENSRNOP00000064123
resolver
genesymbol
Syngr2
resolver
uniprot_entry
SNG2_RAT
resolver
amino_acid_sequence
MESGAYGAANAGGSFDLRRYVSQPQVVTRLVSMVLALIVFSCIFGEGYINLHSSDQLHCVFNRNEDACRYGSAIGVLAFLASAFFLVVDAFFSQISNATDRKYLVIGDLLFSALWTFLWFVGFCFLTNQWAATKPDDVLVGADSARAAITFSFFSIFSWGVLASLAYQRYKAGVDAFIQNYVDPTPDPTTAYASYPSASVENYQQPPFTQNVETTEGYQPPPVY
uniprot
proteins
function
FUNCTION: May play a role in regulated exocytosis (PubMed:10383386). In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles (PubMed:12928441, PubMed:15590695). May also play a role in GLUT4 storage and transport to the plasma membrane (PubMed:26071524). {ECO:0000269|PubMed:10383386, ECO:0000269|PubMed:12928441, ECO:0000269|PubMed:15590695, ECO:0000269|PubMed:26071524}.
uniprot
proteins
mass_dalton
24711
uniprot
proteins
mutagenesis
MUTAGEN 15..17; /note="FDL->AAA: Increased localization to the plasma membrane."; /evidence="ECO:0000269|PubMed:26071524
uniprot
proteins
post_translational_modification
PTM: May be tyrosine phosphorylated by Src. {ECO:0000269|PubMed:9446595}.
uniprot
proteins
protein_family
Synaptogyrin family
uniprot
proteins
pubmed
10383386
uniprot
proteins
pubmed
10967091
uniprot
proteins
pubmed
12928441
uniprot
proteins
pubmed
15590695
uniprot
proteins
pubmed
26071524
uniprot
proteins
pubmed
9446595
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:12928441, ECO:0000269|PubMed:26071524}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:12928441, ECO:0000269|PubMed:9446595}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to cytoplasmic vesicles associated with the recycling endosomes. {ECO:0000269|PubMed:10967091}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 73..93; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 147..167; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins