Robo3
entrez
19649
canonical
uniprot
Q9Z2I4
canonical
ensembl
ENSMUSG00000032128
resolver
ensp
ENSMUSP00000110690
resolver
ensp
ENSMUSP00000168471
resolver
ensp
ENSMUSP00000168476
resolver
genesymbol
Robo3
resolver
genesymbol_syn
Rbig1
resolver
uniprot
A0A1L1SU85
resolver
uniprot
D3Z4M6
resolver
uniprot_entry
ROBO3_MOUSE
resolver
uniprot_sec
A0A1L1SU85
resolver
uniprot_sec
D3Z4M6
resolver
amino_acid_sequence
MLRYLLKTLLQMNLFADSLARDISNSSELLFGFNSSLAALNPSLLPPGDPSLNGSRVGPEDAMPRIVEQPPDLVVSRGEPATLPCRAEGRPRPNIEWYKNGARVATAREDPRAHRLLLPSGALFFPRIVHGRRSRPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVMECVPPKGHPEPLVTWKKGKIKLKEEEGRITIRGGKLMMSHTFKSDAGMYMCVASNMAGERESGAAELVVLERPSFLRRPINQVVLADAPVNFLCEVQGDPQPNLHWRKDDGELPAGRYEIRSDHSLWIDQVSSEDEGTYTCVAENSVGRAEASGSLSVHVPPQFVTKPQNQTVAPGANVSFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPMGRLLVSPRGQLNITEVKIGDGGYYVCQAVSVAGSILAKALLEIKGASIDGLPPIILQGPANQTLVLGSSVWLPCRVIGNPQPNIQWKKDERWLQGDDSQFNLMDNGTLHIASIQEMDMGFYSCVAKSSIGEATWNSWLRKQEDWGASPGPATGPSNPPGPPSQPIVTEVTANSITLTWKPNPQSGATATSYVIEAFSQAAGNTWRTVADGVQLETYTISGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVQTQDSSLSRPAEDPWKGQRGLAEVAVRMQEPTVLGPRTLQVSWTVDGPVQLVQGFRVSWRIAGLDQGSWTMLDLQSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGAESPFVTRSIPEEAPSGPPQGVAVALGGDRNSSVTVSWEPPLPSQRNGVITEYQIWCLGNESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAATSAGVGVASAPVLVQLPFPPAAEPGPEVSEGLAERLAKVLRKPAFLAGSSAACGALLLGFCAALYRRQKQRKELSHYTASFAYTPAVSFPHSEGLSGSSSRPPMGLGPAAYPWLADSWPHPPRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGANASGEGPVYSTIDPVGEELQTFHGGFPQHSSGDPSTWSQYAPPEWSEGDSGARGGQGKLLGKPVQMPSLSWPEALPPPPPSCELSCPEGPEEELKGSSDLEEWCPPVPEKSHLVGSSSSGACMVAPAPRDTPSPTSSYGQQSTATLTPSPPDPPQPPTDIPHLHQMPRRVPLGPSSPLSVSQPALSSHDGRPVGLGAGPVLSYHASPSPVPSTASSAPGRTRQVTGEMTPPLHGHRARIRKKPKALPYRREHSPGDLPPPPLPPPEEETSWPLGLRAAGSMSSLERERSGERRVVQAVPLGAQPLGAQRGPHPDAALLGCAAEEAWLPYGRPSFLSHGQGTSTCSTAGSNSSRGSNSSRGSRGSRGPGRSRSRSRSQSQSQRPGRNRREEPR
uniprot
proteins
function
FUNCTION: Receptor involved in axon guidance during development. Acts as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits SLIT repulsion, and facilitates Netrin-1/NTN1 attraction (PubMed:15084255, PubMed:18466743, PubMed:25433640, PubMed:30843071). In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1/ROBO2 (PubMed:15084255, PubMed:18466743). Binding OF NELL2 to the receptor ROBO3 promotes oligomerization of ROBO3, resulting in the repulsion of commissural axons in the midline (PubMed:30843071, PubMed:32198364). ROBO3 also indirectly boosts axon attraction to NTN1 without interacting with NTN1 itself (PubMed:25433640). {ECO:0000269|PubMed:15084255, ECO:0000269|PubMed:18466743, ECO:0000269|PubMed:25433640, ECO:0000269|PubMed:30843071, ECO:0000269|PubMed:32198364}.; FUNCTION: [Isoform 1]: Mediates NELL2 premature repulsion of commissural axons during midline crossing. {ECO:0000269|PubMed:18466743, ECO:0000269|PubMed:32198364}.; FUNCTION: [Isoform 2]: After midline crossing by the commissural axons, may, in concert with ROBO1 and ROBO2, prevent midline recrossing. Does not mediate NELL2 signaling. {ECO:0000269|PubMed:18466743, ECO:0000269|PubMed:32198364}.
uniprot
proteins
mass_dalton
149899
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
ROBO family
uniprot
proteins
pubmed
10049565
uniprot
proteins
pubmed
14678835
uniprot
proteins
pubmed
15084255
uniprot
proteins
pubmed
18466743
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25433640
uniprot
proteins
pubmed
26586761
uniprot
proteins
pubmed
30843071
uniprot
proteins
pubmed
32198364
uniprot
proteins
sequence_length
1402
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10049565}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 892..912; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins