SYNJ2
entrez
8871
canonical
uniprot
O15056
canonical
ensembl
ENSG00000078269
resolver
ensp
ENSP00000347792
resolver
ensp
ENSP00000356089
resolver
ensp
ENSP00000492369
resolver
ensp
ENSP00000492532
resolver
ensp
ENSP00000751646
resolver
enst
ENST00000638626
resolver
genesymbol
SYNJ2
resolver
genesymbol_syn
KIAA0348
resolver
hgnc
HGNC:11504
resolver
uniprot
A0A1W2PR85
resolver
uniprot
B4DG94
resolver
uniprot
Q5TA13
resolver
uniprot
Q5TA16
resolver
uniprot
Q5TA19
resolver
uniprot
Q86XK0
resolver
uniprot
Q8IZA8
resolver
uniprot
Q9H226
resolver
uniprot_entry
A0A1W2PR85_HUMAN
resolver
uniprot_entry
B4DG94_HUMAN
resolver
uniprot_entry
SYNJ2_HUMAN
resolver
uniprot_sec
Q5TA13
resolver
uniprot_sec
Q5TA16
resolver
uniprot_sec
Q5TA19
resolver
uniprot_sec
Q86XK0
resolver
uniprot_sec
Q8IZA8
resolver
uniprot_sec
Q9H226
resolver
amino_acid_sequence
MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDAYGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIALKKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDWLLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIYMDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLHWEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
ec_number
3.1.3.36
uniprot
proteins
ec_number
3.1.3.95
uniprot
proteins
function
FUNCTION: Phosphatase that hydrolyzes phosphate groups from the inositol ring of phosphoinositides and inositol phosphates, in a domain-specific manner (PubMed:11084340, PubMed:12699622, PubMed:40969890). The 5-PPase domain catalyzes removal of the 5-phosphate from substrates such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) (PubMed:11084340, PubMed:12699622, PubMed:40969890). The SAC domain hydrolyzes phosphates at the 3- and 4-positions of the inositol ring, targeting phosphatidylinositol-3-phosphate (PI(3)P), phosphatidylinositol-4-phosphate (PI(4)P), and phosphatidylinositol-3,5-bisphosphate (PI(3,5)P2) (By similarity). Plays a role in the phosphatidylinositol metabolic process during the early stage of clathrin-coated-pit formation (PubMed:12699622). During EGF activation, plays a role in receptor-mediated endocytosis (RME) by converting PtdIns(4,5)P2 to PtdIns(4)P through the H2O2-dependent oxidation of the 4-phosphatase domain (By similarity). May play a role in tumor cell invadopodia formation (PubMed:23076136). {ECO:0000250|UniProtKB:O55207, ECO:0000269|PubMed:11084340, ECO:0000269|PubMed:12699622, ECO:0000269|PubMed:23076136, ECO:0000269|PubMed:40969890}.
uniprot
proteins
mass_dalton
165538
uniprot
proteins
mutagenesis
MUTAGEN 490; /note="Y->A: Strongly inhibits tyrosine phosphorylation. Decreases phosphoinositide 5-phosphatase."; /evidence="ECO:0000269|PubMed:23076136
uniprot
proteins
post_translational_modification
PTM: The SRC-mediated phosphorylation of Tyr-490 contributes to invadopodia formation by stimulating SYNJ2 5'-phosphatase activity. {ECO:0000269|PubMed:23076136}.; PTM: Oxidized at Cys-386 (By similarity). Oxidation at Cys-386 mediates conversion of PtdIns(4,5)P2 to PtdIns(4)P that is achieved through the H2O2-dependent oxidation of the 4-phosphatase domain of the dual phosphatidylinositol-4,5-bisphosphate phosphatase activity and is required for receptor-mediated endocytosis (RME) during EGF activation (By similarity). {ECO:0000250|UniProtKB:O55207}.
uniprot
proteins
protein_family
4
uniprot
proteins
protein_family
5-trisphosphate 5-phosphatase family
uniprot
proteins
protein_family
Synaptojanin family; Inositol 1
uniprot
proteins
pubmed
11084340
uniprot
proteins
pubmed
11498538
uniprot
proteins
pubmed
12699622
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23076136
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
40969890
uniprot
proteins
pubmed
9205841
uniprot
proteins
sequence_length
1496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11084340}. Cell membrane {ECO:0000269|PubMed:11084340}. Cell projection, ruffle membrane {ECO:0000269|PubMed:11084340}. Presynapse {ECO:0000250|UniProtKB:O55207}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O55207}. Note=Localizes at presynapse terminals in brain and at bundles of microtubules surrounding the nucleus in the elongating spermatids corresponding to the manchette (By similarity). Translocates from the cytoplasm to membrane ruffles in a RAC1-dependent manner (PubMed:11084340). {ECO:0000269|PubMed:11084340}.
uniprot
proteins