Osbpl2
entrez
228983
canonical
uniprot
Q8BX94
canonical
ensembl
ENSMUSG00000039050
resolver
ensp
ENSMUSP00000046538
resolver
ensp
ENSMUSP00000282006
resolver
ensp
ENSMUSP00000282033
resolver
enst
ENSMUST00000040668
resolver
genesymbol
Osbpl2
resolver
uniprot
Q3TCK8
resolver
uniprot
Q8R0H8
resolver
uniprot_entry
OSBL2_MOUSE
resolver
uniprot_sec
Q3TCK8
resolver
uniprot_sec
Q8R0H8
resolver
amino_acid_sequence
MNGEEEFFDAVTGFDSDNSSIGEFSEANKISGMIDLDTSKSTRSGKNGEKPQQENGIQKHRTALPAPMFTRSDFSVWSILKKCIGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHKASSQSQPLERMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPPISAFYSEGLNQDFRFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVILGQLWIEQYGIVEIVNHRTGDKCILHFKPCGLFGKELHRVEGYIQDKNRKKLFIMYGKWTECLWGIDPASYESFKKQEKRGDQARKAKMDDGPEKANSDVPGDVADDVPVAQETVQVIPGSKLLWRINSRPPNSAQMYNFTSFTVSLNELESGMEKTLPPTDCRLRPDIRGMENGNMDLASQEKERLEEKQREARKERAKEDAEWRTRWFSPGNNPYTGAPDWLYAGHYFERNFSDCPDIY
uniprot
proteins
function
FUNCTION: Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro). In conjunction with PLCB3, it may contribute to the control of keratinocyte proliferation and differentiation, probably through the regulation of the ERK pathway and the cell cycle. Involved in angiogenic signaling pathways such as VEGFR2 in endothelial cells. Controls LDL-cholesterol plasma membrane delivery, focal adhesion kinase (FAK) activation and PI(4,5)P2 generation, enhancing cell adhesion. {ECO:0000250|UniProtKB:Q9H1P3}.
uniprot
proteins
mass_dalton
55384
uniprot
proteins
protein_family
OSBP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25759012
uniprot
proteins
sequence_length
484
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9H1P3}. Lipid droplet {ECO:0000250|UniProtKB:Q9H1P3}. Cell membrane {ECO:0000250|UniProtKB:Q9H1P3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H1P3}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H1P3}. Cell projection, stereocilium {ECO:0000269|PubMed:25759012}. Note=Detected on the surface of cytosolic lipid droplets. Recruited to the cell membrane by phosphatidylinositol-phosphate binding. {ECO:0000250|UniProtKB:Q9H1P3}.
uniprot
proteins