Nox3
entrez
224480
canonical
uniprot
Q672J9
canonical
ensembl
ENSMUSG00000023802
resolver
ensp
ENSMUSP00000111466
resolver
enst
ENSMUST00000115800
resolver
genesymbol
Nox3
resolver
uniprot
Q6Y4Q8
resolver
uniprot_entry
NOX3_MOUSE
resolver
uniprot_sec
Q6Y4Q8
resolver
activity_regulation
ACTIVITY REGULATION: Activated by the ototoxic drug cisplatin. Activated by NOXO1. Cooperatively activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)-dependent manner. Inhibited by diphenyleneiodonium chloride. {ECO:0000269|PubMed:15326186, ECO:0000269|PubMed:17140397}.
uniprot
proteins
amino_acid_sequence
MPVCWILNESGSFVVALLWLAVNAYLFIDTFFWYTEEEAFFYTRVILGSALAWARASAVCLNFNCMLILLPVSRNFISLVRGTSVCCRGPWRRQLDKNLNFHKLVAYGIAVNSVIHIVAHLFNLERYHLGQAKDAEGLLAALSKLGDAPNESYLNPVRTFDMGTTTELLMTVSGITGLGISLALVFIMTSSTEFIRRSSYELFWYTHHIFVFFFISLAIHGGGRIIRGQTPESLRLHNVTYCRDHYAEWQAAALCPVPQFSGKEPSAWKWALGPVVLYACERIIRFWRSHQEVVITKVVSHPSAVLELHMKKRDFKMAPGQYIFIQCPSVSPLEWHPFTLTSAPQEDFFSVHIRASGDWTEALLKAFRVEGQAPSELCSMPRLAVDGPFGGSLADVFHYPVSVCIATGIGVTPFASLLKSVWYKCCESQSLPELSKVYFYWICRDAGAFEWFADLLLSLETRMSEQGKAHLLSYHIYLTGWDENQAIHIALHWDESLDVITGLKQKAFYGRPNWNDEFKQIAYNHPSSSIGVFFCGSKAMSKTLQKMCRLYSSVDPRGVHFYYNKENF
uniprot
proteins
ec_number
1.6.3.-
uniprot
proteins
function
FUNCTION: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor, upon formation of a complex with CYBA/p22phox (PubMed:15326186, PubMed:17140397). Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (PubMed:15014044). {ECO:0000269|PubMed:15014044, ECO:0000269|PubMed:15326186, ECO:0000269|PubMed:17140397}.
uniprot
proteins
mass_dalton
64495
uniprot
proteins
mutagenesis
MUTAGEN 408; /note="G->R: Defects in otoconia biogenesis."; /evidence="ECO:0000269|PubMed:15014044"; MUTAGEN 542; /note="K->E: Defects in otoconia biogenesis."; /evidence="ECO:0000269|PubMed:15014044
uniprot
proteins
post_translational_modification
PTM: N-glycosylated in a CYBA/p22phox-dependent manner. {ECO:0000269|PubMed:17140397}.
uniprot
proteins
pubmed
15014044
uniprot
proteins
pubmed
15326186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17140397
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17140397}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 50..70; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 396..416; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins