ACTR6
entrez
64431
canonical
uniprot
Q9GZN1
canonical
ensembl
ENSG00000075089
resolver
ensp
ENSP00000188312
resolver
genesymbol
ACTR6
resolver
hgnc
HGNC:24025
resolver
uniprot
B3KW37
resolver
uniprot
B4DLG9
resolver
uniprot
Q53GH2
resolver
uniprot
Q9BY39
resolver
uniprot
Q9H8H6
resolver
uniprot_entry
ARP6_HUMAN
resolver
uniprot_sec
B3KW37
resolver
uniprot_sec
B4DLG9
resolver
uniprot_sec
Q53GH2
resolver
uniprot_sec
Q9BY39
resolver
uniprot_sec
Q9H8H6
resolver
amino_acid_sequence
MTTLVLDNGAYNAKIGYSHENVSVIPNCQFRSKTARLKTFTANQIDEIKDPSGLFYILPFQKGYLVNWDVQRQVWDYLFGKEMYQVDFLDTNIIITEPYFNFTSIQESMNEILFEEYQFQAVLRVNAGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINVGGKLLTNHLKEIISYRQLHVMDETHVINQVKEDVCYVSQDFYRDMDIAKLKGEENTVMIDYVLPDFSTIKKGFCKPREEMVLSGKYKSGEQILRLANERFAVPEILFNPSDIGIQEMGIPEAIVYSIQNLPEEMQPHFFKNIVLTGGNSLFPGFRDRVYSEVRCLTPTDYDVSVVLPENPITYAWEGGKLISENDDFEDMVVTREDYEENGHSVCEEKFDI
uniprot
proteins
function
FUNCTION: Required for formation and/or maintenance of proper nucleolar structure and function (PubMed:26164235). Plays a dual role in the regulation of ribosomal DNA (rDNA) transcription (By similarity). In the presence of high glucose, maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, is required for the repression of rDNA transcription, and this function may be independent of H2A.Z (By similarity). {ECO:0000250|UniProtKB:Q9DEE9, ECO:0000269|PubMed:26164235}.
uniprot
proteins
mass_dalton
45810
uniprot
proteins
protein_family
ARP6 subfamily
uniprot
proteins
protein_family
Actin family
uniprot
proteins
pubmed
11368909
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15647280
uniprot
proteins
pubmed
16487625
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20473270
uniprot
proteins
pubmed
26164235
uniprot
proteins
pubmed
30337683
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P45890}. Nucleus {ECO:0000269|PubMed:16487625}. Nucleus, nucleolus {ECO:0000269|PubMed:26164235}. Note=Colocalizes with HP1 family proteins at pericentric heterochromatin. {ECO:0000269|PubMed:16487625}.
uniprot
proteins