FMO2
entrez
2327
canonical
uniprot
Q99518
canonical
ensembl
ENSG00000094963
resolver
ensp
ENSP00000209929
resolver
ensp
ENSP00000565573
resolver
enst
ENST00000209929
resolver
enst
ENST00000895514
resolver
genesymbol
FMO2
resolver
hgnc
HGNC:3770
resolver
uniprot
B4E2Q9
resolver
uniprot
Q5EBX4
resolver
uniprot
Q86U73
resolver
uniprot
Q9BRX1
resolver
uniprot_entry
B4E2Q9_HUMAN
resolver
uniprot_entry
FMO2_HUMAN
resolver
uniprot_sec
Q5EBX4
resolver
uniprot_sec
Q86U73
resolver
uniprot_sec
Q9BRX1
resolver
amino_acid_sequence
MAKKVAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGVWRFKENVEDGRASIYQSVVTNTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLKYIQFQTTVLSVRKCPDFSSSGQWKVVTQSNGKEQSAVFDAVMVCSGHHILPHIPLKSFPGMERFKGQYFHSRQYKHPDGFEGKRILVIGMGNSGSDIAVELSKNAAQVFISTRHGTWVMSRISEDGYPWDSVFHTRFRSMLRNVLPRTAVKWMIEQQMNRWFNHENYGLEPQNKYIMKEPVLNDDVPSRLLCGAIKVKSTVKELTETSAIFEDGTVEENIDVIIFATGYSFSFPFLEDSLVKVENNMVSLYKYIFPAHLDKSTLACIGLIQPLGSIFPTAELQARWVTRVFKGLCSLPSERTMMMDIIKRNEKRIDLFGESQSQTLQTNYVDYLDELALEIGAKPDFCSLLFKDPKLAVRLYFGPCNSYQYRLVGPGQWEGARNAIFTQKQRILKPLKTRALKDSSNFSVSFLLKILGLLAVVVAFFCQLQWS
uniprot
proteins
ec_number
1.14.13.-
uniprot
proteins
function
FUNCTION: Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation (PubMed:15144220, PubMed:15294458, PubMed:18930751, PubMed:18948378, PubMed:9804831). Specifically catalyzes S-oxygenation of sulfur derived compounds such as thioureas-derived compounds, thioetherorganophosphates to their sulfenic acid (PubMed:15144220, PubMed:9804831). In vitro, catalyzes S-oxygenation of the second-line antitubercular drugs thiacetazone (TAZ) and ethionamide (ETA), forming a sulfinic acid and a carbodiimide via a postulated sulfenic acid intermediate (PubMed:18930751, PubMed:18948378). Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton (PubMed:15294458). {ECO:0000269|PubMed:15144220, ECO:0000269|PubMed:15294458, ECO:0000269|PubMed:18930751, ECO:0000269|PubMed:18948378, ECO:0000269|PubMed:9804831}.
uniprot
proteins
mass_dalton
60907
uniprot
proteins
protein_family
FMO family
uniprot
proteins
pubmed
11042094
uniprot
proteins
pubmed
12527699
uniprot
proteins
pubmed
15144220
uniprot
proteins
pubmed
15294458
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18794725
uniprot
proteins
pubmed
18930751
uniprot
proteins
pubmed
18948378
uniprot
proteins
pubmed
20388717
uniprot
proteins
pubmed
9804831
uniprot
proteins
sequence_length
535
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:P17635}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P17635}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 510..530; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins