JAML
entrez
120425
canonical
uniprot
Q86YT9
canonical
ensembl
ENSG00000160593
resolver
ensp
ENSP00000292067
resolver
ensp
ENSP00000348635
resolver
ensp
ENSP00000431218
resolver
ensp
ENSP00000431614
resolver
genesymbol
AMICA1
resolver
genesymbol
JAML
resolver
genesymbol_syn
AMICA1
resolver
hgnc
HGNC:19084
resolver
uniprot
B0YIV1
resolver
uniprot
B0YIV2
resolver
uniprot
B3KUI3
resolver
uniprot
Q496M1
resolver
uniprot
Q496M4
resolver
uniprot
Q5DTC6
resolver
uniprot
Q7Z499
resolver
uniprot
Q8N9I7
resolver
uniprot
Q8NF70
resolver
uniprot_entry
B3KUI3_HUMAN
resolver
uniprot_entry
JAML_HUMAN
resolver
uniprot_entry
Q496M4_HUMAN
resolver
uniprot_sec
B0YIV1
resolver
uniprot_sec
B0YIV2
resolver
uniprot_sec
Q496M1
resolver
uniprot_sec
Q5DTC6
resolver
uniprot_sec
Q7Z499
resolver
uniprot_sec
Q8N9I7
resolver
uniprot_sec
Q8NF70
resolver
amino_acid_sequence
MFCPLKLILLPVLLDYSLGLNDLNVSPPELTVHVGDSALMGCVFQSTEDKCIFKIDWTLSPGEHAKDEYVLYYYSNLSVPIGRFQNRVHLMGDILCNDGSLLLQDVQEADQGTYICEIRLKGESQVFKKAVVLHVLPEEPKELMVHVGGLIQMGCVFQSTEVKHVTKVEWIFSGRRAKEEIVFRYYHKLRMSVEYSQSWGHFQNRVNLVGDIFRNDGSIMLQGVRESDGGNYTCSIHLGNLVFKKTIVLHVSPEEPRTLVTPAALRPLVLGGNQLVIIVGIVCATILLLPVLILIVKKTCGNKSSVNSTVLVKNTKKTNPEIKEKPCHFERCEGEKHIYSPIIVREVIEEEEPSEKSEATYMTMHPVWPSLRSDRNNSLEKKSGGGMPKTQQAF
uniprot
proteins
function
FUNCTION: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. {ECO:0000269|PubMed:12869515, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:18948633, ECO:0000269|PubMed:19064666}.
uniprot
proteins
mass_dalton
44339
uniprot
proteins
mutagenesis
MUTAGEN 54; /note="K->E: Loss of the ability to homodimerize, loss of interaction with CXADR and loss of function in cell-cell adhesion."; /evidence="ECO:0000269|PubMed:12869515, ECO:0000269|PubMed:19064666
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
12869515
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15800062
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18948633
uniprot
proteins
pubmed
19064666
uniprot
proteins
sequence_length
394
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12869515}; Single-pass type I membrane protein {ECO:0000269|PubMed:12869515}. Cell junction {ECO:0000269|PubMed:12869515}. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).
uniprot
proteins
transmembrane_region
TRANSMEM 276..296; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins