FAM21A
entrez
387680
canonical
uniprot
Q641Q2
canonical
ensembl
ENSG00000099290
resolver
ensp
ENSP00000282633
resolver
ensp
ENSP00000314417
resolver
ensp
ENSP00000344037
resolver
ensp
ENSP00000382277
resolver
ensp
ENSP00000481763
resolver
ensp
ENSP00000549406
resolver
ensp
ENSP00000549408
resolver
ensp
ENSP00000549409
resolver
ensp
ENSP00000549410
resolver
ensp
ENSP00000549411
resolver
ensp
ENSP00000549412
resolver
ensp
ENSP00000549414
resolver
ensp
ENSP00000549415
resolver
ensp
ENSP00000549420
resolver
ensp
ENSP00000584937
resolver
ensp
ENSP00000584940
resolver
ensp
ENSP00000584943
resolver
ensp
ENSP00000627601
resolver
ensp
ENSP00000627604
resolver
ensp
ENSP00000627609
resolver
ensp
ENSP00000627612
resolver
ensp
ENSP00000627613
resolver
ensp
ENSP00000681356
resolver
enst
ENST00000314664
resolver
enst
ENST00000611324
resolver
genesymbol
FAM21A
resolver
genesymbol
WASHC2A
resolver
genesymbol_syn
FAM21A
resolver
genesymbol_syn
FAM21B
resolver
hgnc
HGNC:23416
resolver
uniprot
A0A087WYF6
resolver
uniprot
A2A3S2
resolver
uniprot
A2A3U6
resolver
uniprot
E7ESD2
resolver
uniprot
Q5SNT6
resolver
uniprot
Q6DHY0
resolver
uniprot
Q6P0Q7
resolver
uniprot_entry
A0A087WYF6_HUMAN
resolver
uniprot_entry
E7ESD2_HUMAN
resolver
uniprot_entry
Q6P0Q7_HUMAN
resolver
uniprot_entry
WAC2A_HUMAN
resolver
uniprot_sec
A2A3S2
resolver
uniprot_sec
A2A3U6
resolver
uniprot_sec
Q5SNT6
resolver
uniprot_sec
Q6DHY0
resolver
amino_acid_sequence
MMNRTTPDQELAPASEPVWERPWSVEEIRRSSQSWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIRETKATDCRLHNVFNDFLMLSNTQFIENRVYDEEVEEPVLKAEAEKTEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANGRVELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDTEEEKEEEESDEDFAHHSDNEQNRHTTQMSDEEEDDDGCDLFADSEKEEEDIEDIEENTRPKRSRPTSFADELAARIKGDAVGRVDEEPTTLPSGEAKPRKTLKEKKERRTPSDDEEDNLFAPPKLTDEDFSPFGSGGGLFSGGKGLFDDEDEESDLFTEAPQDRQAGASVKEESSSSKPGKKIPAGAVSVFLGDTDVFGAASVPSMKEPQKPEQPTPRKSPYGPPPTGLFDDDDGDDDDDFFSAPHSKPSKTGKVQSTADIFGDEEGDLFKEKAVASPEATVSQTDENKARAEKKVTLSSSKNLKPSSETKTQKGLFSDEEDSEDLFSSQSASKLKGASLLPGKLPTLVSLFDDEDEEDNLFGGTAAKKQTLCLQAQREEKAKASELSKKKASALLFSSDEEDQWNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVKKTSLFEEDEEDDLFAIAKDSQKKTQRVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVSEAPPLLFSDEEEKEAQLGVKSVDKKVESAKESLKFGRTDVAESEKEGLLTRSAQETVKHSDLFSSSSPWDKGTKPRTKTVLSLFDEEEDKMEDQNIIQAPQKEVGKGRDPDAHPKSTGVFQDEELLFSHKLQKDNDPDVDLFAGTKKTKLLEPSVGSLFGDDEDDDLFSSAKSQPLVQEKKRVVKKDHSVDSFKNQKHPESIQGSKEKGIWKPETPQDSSGLAPFKTKEPSTRIGKIQANLAINPAALLPTAASQISEVKPVLPELAFPSSEHRRSHGLESVPVLPGSGEAGVSFDLPAQADTLHSANKSRVKMRGKRRPQTRAARRLAAQESSETEDMSVPRGPIAQWADGAISPNGHRPQLRAASGEDSTEEALAAAAAPWEGGPVPGVDRSPFAKSLGHSRGEADLFDSGDIFSTGTGSQSVERTKPKAKIAENPANPPVGGKAKSPMFPALGEASSDDDLFQSAKPKPAKKTNPFPLLEDEDDLFTDQKVKKNETKSNSQQDVILTTQDIFEDDIFATEAIKPSQKTREKEKTLESNLFDDNIDIFADLTVKPKEKSKKKVEAKSIFDDDMDDIFSSGIQAKTTKPKSRSAQAAPEPRFEHKVSNIFDDPLNAFGGQ
uniprot
proteins
function
FUNCTION: Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
uniprot
proteins
mass_dalton
147184
uniprot
proteins
protein_family
FAM21 family
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25355947
uniprot
proteins
pubmed
28892079
uniprot
proteins
pubmed
29084197
uniprot
proteins
sequence_length
1341
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:28892079}. Cell membrane {ECO:0000250|UniProtKB:Q9Y4E1}.
uniprot
proteins