Dgkz
entrez
81821
canonical
uniprot
O08560
canonical
ensembl
ENSRNOG00000017737
resolver
ensembl
ENSRNOG00055016451
resolver
ensembl
ENSRNOG00060010508
resolver
ensembl
ENSRNOG00065024021
resolver
ensp
ENSRNOP00000024280
resolver
ensp
ENSRNOP00000074012
resolver
ensp
ENSRNOP00000087400
resolver
ensp
ENSRNOP00000097565
resolver
ensp
ENSRNOP00055022602
resolver
ensp
ENSRNOP00060013951
resolver
ensp
ENSRNOP00065034147
resolver
enst
ENSRNOT00000024280
resolver
enst
ENSRNOT00000091265
resolver
enst
ENSRNOT00000095998
resolver
enst
ENSRNOT00000117598
resolver
enst
ENSRNOT00055028087
resolver
enst
ENSRNOT00060017946
resolver
enst
ENSRNOT00065041777
resolver
genesymbol
Dgkz
resolver
genesymbol_syn
Dagk6
resolver
uniprot
A0A0G2K707
resolver
uniprot
A0A8I6A444
resolver
uniprot
A0A8I6GM44
resolver
uniprot_entry
A0A0G2K707_RAT
resolver
uniprot_entry
A0A8I6A444_RAT
resolver
uniprot_entry
A0A8I6GM44_RAT
resolver
uniprot_entry
DGKZ_RAT
resolver
amino_acid_sequence
MEPRDPSPEARSSDSESASASSSGSERDADPEPDKAPRRLTKRRFPGLRLFGHRKAITKSGLQHLAPPPPTPGAPCGESERQIRSTVDWSESAAYGEHIWFETNVSGDFCYVGEQYCVAKMLPKSAPRRKCAACKIVVHTPCIGQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRRSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPREALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLRAEPNPEAGPEERDDGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCIVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVLLTTAKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSTAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPMCHPLSSKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPASPCSPTPGSLQGDAALPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDHQSRTLLHHAVSTGSKEVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
uniprot
proteins
ec_number
2.7.1.107
uniprot
proteins
ec_number
2.7.1.93
uniprot
proteins
function
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (By similarity). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (By similarity). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity). Regulates RASGRP1 activity (By similarity). {ECO:0000250|UniProtKB:Q13574, ECO:0000250|UniProtKB:Q80UP3}.
uniprot
proteins
mass_dalton
104009
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000250|UniProtKB:Q13574}.
uniprot
proteins
protein_family
Eukaryotic diacylglycerol kinase family
uniprot
proteins
pubmed
15157668
uniprot
proteins
pubmed
8855332
uniprot
proteins
sequence_length
929
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8855332}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q13574}. Cell membrane {ECO:0000250|UniProtKB:Q13574}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q13574}.
uniprot
proteins