Slc25a23
entrez
66972
canonical
uniprot
Q6GQS1
canonical
ensembl
ENSMUSG00000046329
resolver
ensp
ENSMUSP00000040198
resolver
ensp
ENSMUSP00000295101
resolver
ensp
ENSMUSP00000295103
resolver
ensp
ENSMUSP00000295112
resolver
enst
ENSMUST00000040280
resolver
genesymbol
Slc25a23
resolver
genesymbol_syn
Scamc3
resolver
uniprot
Q9D908
resolver
uniprot_entry
Q9D908_MOUSE
resolver
uniprot_entry
SCMC3_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by an increase in cytosolic calcium levels that induce a conformational change of the N-terminal regulatory domain, uncapping the channel and allowing transport. {ECO:0000250|UniProtKB:Q6NUK1}.
uniprot
proteins
amino_acid_sequence
MRGGSSDAERRQRWGRLFEELDSNKDGRVDVHELRQGLARLGRGDPDRAQQGVSSDWDADPDGGLSLEEFTRYLQEREQRLLLMFHSLDRNQDGHIDVSEIQQSFRALGISISLEQAEKILHSMDRDGTMTIDWQEWRDHFLLHSLENVEDVLYFWKHSTVLDIGECLTVPDEFSQEEKLTGMWWKQLVAGAVAGAVSRTGTAPLDRLKVFMQVHASKSNRLNILGGLRNMIQEGGVLSLWRGNGINVLKIAPESAIKFMAYEQIKRAIRGQQETLHVQERFVAGSLAGATAQTIIYPMEVLKTRLTLRRTGQYKGLLDCAKRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETLKNRWLQQYSHESANPGILVLLGCGTISSTCGQIASYPLALVRTRMQAQASIEGGPQVSMVGLLRHILSQEGVWGLYRGIAPNFMKVIPAVSISYVVYENMKQALGVTSR
uniprot
proteins
function
FUNCTION: Electroneutral antiporter that mediates the transport of adenine nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenine nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenine nucleotide-dependent metabolic pathways. Also acts as a regulator of mitochondrial calcium uptake and can probably transport trace amounts of other divalent metal cations in complex with ATP. In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides. {ECO:0000250|UniProtKB:Q9BV35}.
uniprot
proteins
mass_dalton
52497
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
15054102
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:15054102}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 188..205; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 243..262; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 286..299; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 336..355; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 379..396; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 436..455; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins