Psmc3ip
entrez
140938
canonical
uniprot
Q91ZY6
canonical
ensembl
ENSRNOG00000020022
resolver
ensp
ENSRNOP00000027159
resolver
genesymbol
Psmc3ip
resolver
uniprot_entry
HOP2_RAT
resolver
amino_acid_sequence
MSKSRAEAAAGAPGIVLRYLQEQNRPYSAQDVFGNLQKEHGLGKAAVVKALDQLAQQGKIKEKTYGKQKIYFADQDQFDTVSDADLHSLDASIMALTAKVQGLQQSCRHMEAELKELTSALTTPEMQTEIQELKKECARYTERLKNIKAATNHVTPEEKEKVYRERQKYCKEWRKRKRMTTELCDAILEGYPKSKKQFFEEVGIETDEDHNVTLPNP
uniprot
proteins
function
FUNCTION: Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3 (By similarity). Plays a role as a coactivator in nuclear receptor-mediated transcription. {ECO:0000250, ECO:0000269|PubMed:11739747}.
uniprot
proteins
mass_dalton
24768
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA, PKC and MAPK. {ECO:0000269|PubMed:11739747}.
uniprot
proteins
protein_family
HOP2 family
uniprot
proteins
pubmed
11739747
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins