Sptssb
entrez
66183
canonical
uniprot
Q925E8
canonical
ensembl
ENSMUSG00000043461
resolver
ensp
ENSMUSP00000062794
resolver
ensp
ENSMUSP00000131241
resolver
enst
ENSMUST00000051239
resolver
enst
ENSMUST00000171529
resolver
genesymbol
Sptssb
resolver
genesymbol_syn
Admp
resolver
genesymbol_syn
Sssptb
resolver
uniprot_entry
SPTSB_MOUSE
resolver
amino_acid_sequence
MDFKRVKEYFAWLYYQYQIITCCAVMEPWEQSMLNTIILTIVAMVVYTAYVFIPIHIRLAWEFFSKICGYDSSISN
uniprot
proteins
function
FUNCTION: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSB stimulates the catalytic activity and plays a role in substrate specificity. SPT complexes with this subunit showing a preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. {ECO:0000250|UniProtKB:Q8NFR3}.
uniprot
proteins
mass_dalton
9108
uniprot
proteins
mutagenesis
MUTAGEN 56; /note="H->L: Mutant mice develop early onset ataxia, exhibit reduced body weight and usually die around 10 weeks after birth. Increases SPT affininity toward C18-CoA substrate by twofold and elevates C20 long chain base production in the brain and eye. Produces neurodegenerative effects such as aberrant membrane structures, accumulation of ubiquitinated protein on membranes and axon degeneration."; /evidence="ECO:0000269|PubMed:26438849
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:26438849}.
uniprot
proteins
protein_family
SPTSS family
uniprot
proteins
protein_family
SPTSSB subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15777716
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
26438849
uniprot
proteins
sequence_length
76
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 37..57; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins