Tcea2
entrez
29575
canonical
uniprot
Q63799
canonical
ensembl
ENSRNOG00000016288
resolver
ensp
ENSRNOP00000022073
resolver
ensp
ENSRNOP00000112743
resolver
enst
ENSRNOT00000022073
resolver
genesymbol
Tcea2
resolver
genesymbol_syn
Siit1
resolver
uniprot
A0A8L2QBN2
resolver
uniprot_entry
A0A8L2QBN2_RAT
resolver
uniprot_entry
TCEA2_RAT
resolver
amino_acid_sequence
MGKEEEIARIARRLDKMVTRKNAEGAMDLLRELKNMPITLHLLQSTRVGMSVNALRKQSSDEELIALAKSLIKSWKKLLDVSDGKSRDQGRGTPLPTSSSKDASGTTDLSCKKPDPPRTSSTPRITTFPQVPITCDAVRNKCREMLTLALQTDHDHVAVGVSCEHLSSQIEECIFLDVGNTDMKYKNRVRSRISNLKDAKNPGLRRNVLCGAITPQQIAVMTSEEMASDELKEIRKAMTKEAIREHQMARTGGTQTDLFTCNKCRKKNCTYTQVQTRSSDEPMTTYVVCNECGNRWKFC
uniprot
proteins
function
FUNCTION: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. {ECO:0000269|PubMed:8300645}.
uniprot
proteins
mass_dalton
33528
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1; leading to proteasomal degradation and RNAP complex remodeling. {ECO:0000250|UniProtKB:Q15560}.
uniprot
proteins
protein_family
TFS-II family
uniprot
proteins
pubmed
8300645
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins