SCG3
entrez
29106
canonical
uniprot
Q8WXD2
canonical
ensembl
ENSG00000104112
resolver
ensp
ENSP00000220478
resolver
ensp
ENSP00000445205
resolver
genesymbol
SCG3
resolver
hgnc
HGNC:13707
resolver
uniprot
A8K2B0
resolver
uniprot
B3KQP6
resolver
uniprot
B4DK99
resolver
uniprot
F5H3R8
resolver
uniprot
Q96C83
resolver
uniprot
Q96GE8
resolver
uniprot
Q9Y6G7
resolver
uniprot_entry
SCG3_HUMAN
resolver
uniprot_sec
A8K2B0
resolver
uniprot_sec
B3KQP6
resolver
uniprot_sec
B4DK99
resolver
uniprot_sec
F5H3R8
resolver
uniprot_sec
Q96C83
resolver
uniprot_sec
Q96GE8
resolver
uniprot_sec
Q9Y6G7
resolver
amino_acid_sequence
MGFLGTGTWILVLVLPIQAFPKPGGSQDKSLHNRELSAERPLNEQIAEAEEDKIKKTYPPENKPGQSNYSFVDNLNLLKAITEKEKIEKERQSIRSSPLDNKLNVEDVDSTKNRKLIDDYDSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARIYEENDRAVFDKIVSKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFPAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEAEAIKRIYSSL
uniprot
proteins
function
FUNCTION: Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:19357184). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed:29154827). {ECO:0000250|UniProtKB:P47868, ECO:0000269|PubMed:19357184, ECO:0000269|PubMed:29154827}.
uniprot
proteins
mass_dalton
53005
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000269|PubMed:23234360, ECO:0000269|PubMed:25326458}.
uniprot
proteins
pubmed
12098761
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17200173
uniprot
proteins
pubmed
19357184
uniprot
proteins
pubmed
23234360
uniprot
proteins
pubmed
25326458
uniprot
proteins
pubmed
29154827
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P47868}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P47868}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000269|PubMed:12098761, ECO:0000269|PubMed:25326458}. Note=Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts. {ECO:0000250|UniProtKB:P47868}.
uniprot
proteins