Gcsam
entrez
14525
canonical
uniprot
Q6RFH4
canonical
ensembl
ENSMUSG00000022659
resolver
ensp
ENSMUSP00000023339
resolver
ensp
ENSMUSP00000123853
resolver
genesymbol
Gcsam
resolver
genesymbol_syn
Gcet
resolver
genesymbol_syn
Gcet2
resolver
genesymbol_syn
M17
resolver
uniprot
Q60691
resolver
uniprot
Q8CB90
resolver
uniprot_entry
GCSAM_MOUSE
resolver
uniprot_sec
Q60691
resolver
uniprot_sec
Q8CB90
resolver
amino_acid_sequence
MGNCLQRTTRWQLDMQETPWNLRLSAKGRTCRYFRGWSCCHSVEGCSCLPWKNIRTFKARQESPKQNEGMTSAPVQDNANETYTEELCYILVDHEAVRGRPSVNPAEGFYENISNKAERHKESSRGTETEYSVLRFPSPPQPLPSTDDEYELLMPSRFSSHAFQQPRPLTTPYETHFSYPQ
uniprot
proteins
function
FUNCTION: Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000250}.
uniprot
proteins
mass_dalton
20988
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN. {ECO:0000250}.; PTM: Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation. {ECO:0000250|UniProtKB:Q8N6F7}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23299888
uniprot
proteins
pubmed
7981148
uniprot
proteins
sequence_length
181
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:Q8N6F7}. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6. {ECO:0000250}.
uniprot
proteins