Cldn8
entrez
54420
canonical
uniprot
Q9Z260
canonical
ensembl
ENSMUSG00000050520
resolver
ensp
ENSMUSP00000051887
resolver
enst
ENSMUST00000049697
resolver
genesymbol
Cldn8
resolver
uniprot
Q3UZK2
resolver
uniprot_entry
CLD8_MOUSE
resolver
uniprot_entry
Q3UZK2_MOUSE
resolver
amino_acid_sequence
MATYALQMAALVLGGVGMVGTVAVTIMPQWRVSAFIESNIVVFENRWEGLWMNCMRHANIRMQCKVYDSLLALSPDLQASRGLMCAASVLAFLAFMTAILGMKCTRCTGDDENVKSRILLTAGIIFFITGLVVLIPVSWVANSIIRDFYNPLVDVALKRELGEALYIGWTTALVLIAGGALFCCVFCCTERSNSYRYSVPSHRTTQRSFHAEKRSPSIYSKSQYV
uniprot
proteins
function
FUNCTION: Can associate with other claudins to regulate tight junction structural and functional strand dynamics (By similarity). May coassemble with CLDN4 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity) (PubMed:20921420, PubMed:25831548). Cannot form tight junction strands on its own (By similarity). {ECO:0000250|UniProtKB:P56748, ECO:0000269|PubMed:20921420, ECO:0000269|PubMed:25831548}.
uniprot
proteins
mass_dalton
24947
uniprot
proteins
mutagenesis
MUTAGEN 213; /note="K->R: Resistant to KLHL3-dependent protein degradation."; /evidence="ECO:0000269|PubMed:25831548
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the BCR(KLHL3) E3 ubiquitin ligase complex in the kidney, leading to its degradation. {ECO:0000269|PubMed:25831548}.
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
10601346
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20921420
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25831548
uniprot
proteins
pubmed
9892664
uniprot
proteins
sequence_length
225
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:20921420, ECO:0000269|PubMed:25831548, ECO:0000269|PubMed:9892664}. Cell membrane {ECO:0000269|PubMed:20921420, ECO:0000269|PubMed:9892664}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins