Q86UQ8
uniprot
Q86UQ8
canonical
amino_acid_sequence
MPRVVCWHTLKSLNGYKNLSSGAETREGLRSSSPVDLPLRPRKQATAAGQRKLLSLQLLLCACTSVTDLTYWGPAGHGATAPHRSLLAIHLHLVPASSAAMKATGPHNAQTQVNPQGHAPSAEDPTGTWTVSGPCKDHPHPFLSQSNPPTRISSALPLKTDSALEQTPQQLPSLHLSQG
uniprot
proteins
function
FUNCTION: Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma-globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter. {ECO:0000269|PubMed:11003662, ECO:0000269|PubMed:15084587, ECO:0000269|PubMed:16263792}.
uniprot
proteins
mass_dalton
19019
uniprot
proteins
mutagenesis
MUTAGEN 43; /note="K->R: Abolishes acetylation."; /evidence="ECO:0000269|PubMed:15273251
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-43 prolongs the protein half-life by preventing ubiquitin-mediated degradation and reduces the interaction between NF-E4 and HDAC1, potentially maximizing the activating ability of the factor at the gamma-promoter. {ECO:0000269|PubMed:15273251}.; PTM: Ubiquitinated; leading to its degradation by the proteasome. Acetylation at Lys-43 prevents ubiquitination. {ECO:0000269|PubMed:15273251}.
uniprot
proteins
pubmed
11003662
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15084587
uniprot
proteins
pubmed
15273251
uniprot
proteins
pubmed
16263792
uniprot
proteins
sequence_length
179
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins