Mc4r
entrez
17202
canonical
uniprot
P56450
canonical
ensembl
ENSMUSG00000047259
resolver
ensp
ENSMUSP00000054776
resolver
enst
ENSMUST00000057942
resolver
genesymbol
Mc4r
resolver
uniprot
Q49NR4
resolver
uniprot
Q9EQM7
resolver
uniprot_entry
MC4R_MOUSE
resolver
uniprot_sec
Q49NR4
resolver
uniprot_sec
Q9EQM7
resolver
amino_acid_sequence
MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (By similarity). Functions as a central component of the leptin-melanocortin pathway, which is essential for maintaining energy homeostasis (PubMed:23869016). Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which promotes anorexogenic signaling in the hypothalamus and contributes to a negative energy balance (PubMed:23869016). Regulates food intake: activation by agonists suppresses appetite, whereas the antagonist Agouti-related protein/AGRP precludes agonist-induced signaling, thereby stimulating appetite (PubMed:9019399). Modulates the firing activity of neurons in paraventricular nucleus (PVN) of the hypothalamus via alpha-MSH and AGRP regulation of inwardly rectifying potassium channel KCNJ13 closure, independently of G(s) signaling (PubMed:25600267). In the PVN, also interacts with opsin 3/OPN3, which couples to G(i/o) proteins to inhibit MC4R-mediated cAMP signaling, thereby promoting food intake (PubMed:39951488). In intestinal epithelial cells, contributes to inhibition of hepatic glucose production via nesfatin-1/NUCB2, leading to increased cAMP levels and glucagon-like peptide 1 (GLP-1) secretion (By similarity). Interaction with MGRN1 displaces the G(s) protein, further decreasing MC4R signaling activity. Also activated by gamma-MSH, though with low potency (By similarity). {ECO:0000250|UniProtKB:P32245, ECO:0000269|PubMed:23869016, ECO:0000269|PubMed:25600267, ECO:0000269|PubMed:39951488, ECO:0000269|PubMed:9019399}.
uniprot
proteins
mass_dalton
36959
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14531729
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23869016
uniprot
proteins
pubmed
25600267
uniprot
proteins
pubmed
39951488
uniprot
proteins
pubmed
9019399
uniprot
proteins
sequence_length
332
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P32245}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:P32245}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P32245}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..63; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P32245"; TRANSMEM 84..107; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P32245"; TRANSMEM 119..145; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P32245"; TRANSMEM 167..188; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P32245"; TRANSMEM 192..214; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P32245"; TRANSMEM 244..267; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P32245"; TRANSMEM 280..302; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P32245
uniprot
proteins