MAPK6
entrez
5597
canonical
uniprot
Q16659
canonical
ensembl
ENSG00000069956
resolver
ensp
ENSP00000261845
resolver
ensp
ENSP00000505601
resolver
ensp
ENSP00000505862
resolver
ensp
ENSP00000506036
resolver
ensp
ENSP00000506184
resolver
ensp
ENSP00000509662
resolver
ensp
ENSP00000565575
resolver
ensp
ENSP00000625464
resolver
ensp
ENSP00000625465
resolver
ensp
ENSP00000672785
resolver
ensp
ENSP00000672786
resolver
ensp
ENSP00000672787
resolver
ensp
ENSP00000680779
resolver
enst
ENST00000261845
resolver
enst
ENST00000680066
resolver
enst
ENST00000680652
resolver
enst
ENST00000680777
resolver
enst
ENST00000681888
resolver
enst
ENST00000691380
resolver
enst
ENST00000895516
resolver
enst
ENST00000955405
resolver
enst
ENST00000955406
resolver
genesymbol
MAPK6
resolver
genesymbol_syn
ERK3
resolver
genesymbol_syn
PRKM6
resolver
hgnc
HGNC:6879
resolver
uniprot
B2R945
resolver
uniprot
B5BU65
resolver
uniprot
Q68DH4
resolver
uniprot
Q8IYN8
resolver
uniprot_entry
MK06_HUMAN
resolver
uniprot_sec
B2R945
resolver
uniprot_sec
B5BU65
resolver
uniprot_sec
Q68DH4
resolver
uniprot_sec
Q8IYN8
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation at Ser-189.
uniprot
proteins
amino_acid_sequence
MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYSTEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQHEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSGGEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEGFLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHLN
uniprot
proteins
ec_number
2.7.11.24
uniprot
proteins
function
FUNCTION: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
82681
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. {ECO:0000269|PubMed:21177870}.; PTM: Ubiquitination at Met-1 leads to degradation by the proteasome pathway. {ECO:0000269|PubMed:15226418}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MAP kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15226418
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21177870
uniprot
proteins
pubmed
22645313
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
7969157
uniprot
proteins
pubmed
8875998
uniprot
proteins
sequence_length
721
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. {ECO:0000250}.
uniprot
proteins