Obox3
entrez
246791
canonical
uniprot
Q3UT54
canonical
ensembl
ENSMUSG00000066772
resolver
ensp
ENSMUSP00000092842
resolver
ensp
ENSMUSP00000133427
resolver
ensp
ENSMUSP00000134531
resolver
enst
ENSMUST00000095217
resolver
enst
ENSMUST00000173912
resolver
enst
ENSMUST00000174443
resolver
genesymbol
Obox3
resolver
genesymbol_syn
Ohx
resolver
uniprot
D3YXK4
resolver
uniprot
G3UXQ8
resolver
uniprot
G3UXT3
resolver
uniprot
G3UZJ7
resolver
uniprot
Q8JZN9
resolver
uniprot
Q8VHG6
resolver
uniprot_entry
OBOX3_MOUSE
resolver
uniprot_sec
D3YXK4
resolver
uniprot_sec
G3UXQ8
resolver
uniprot_sec
G3UXT3
resolver
uniprot_sec
G3UZJ7
resolver
uniprot_sec
Q8JZN9
resolver
uniprot_sec
Q8VHG6
resolver
amino_acid_sequence
MAEGPSLHPKLQVASNIPIELSSQIPQDPARNLAFQMCQNPLMTPGSTMQSRLSVPERNLLQQESQGPTRQSGRMPLSDRYVNKQTGPMALRKFRKERTVYSKEQQCLLQKHFDEFQYPNEKKIVELALSVGVTKREIKIWFKNNRAKYRRMKLQNIKQALPETNESSKAVSESTHFPGSIPVVDSDNGESMCSGTFGEDSIPKLNCSQESSLHCFQACDGDMCCPQEYQEYQEYLLHGHAPVTAWNSGQSAAFESQTDLAVAEVPVGLAYAAQAPEDAHNSGPCEDELWQRILEDLDTSDDWLTLRNLSTPVYTTEVLDQSKPYSHEEVCYTHL
uniprot
proteins
function
FUNCTION: Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:37459895). Together with other Obox family members, required in early two-cell stage embryos to kick-start the major ZGA wave by facilitating RNA Polymerase II 'pre-configuration', during which RNA Polymerase II relocates from the initial one-cell stage binding targets to ZGA gene promoters and distal enhancers (PubMed:37459895). Mechanistically, promotes recruitment of RNA Polymerase II from (CG-rich) non-ZGA genes to (CG-poor) ZGA genes at the two-cell stage (PubMed:37459895). Binds to regulatory DNA sequences containing a 5'-ACNCCTTTAATCCCAG-3' sequence motif (PubMed:37459895). Most maternal and zygotic Obox family proteins can compensate for one another (PubMed:37459895). {ECO:0000269|PubMed:37459895}.
uniprot
proteins
mass_dalton
37777
uniprot
proteins
protein_family
Obox subfamily
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
11991721
uniprot
proteins
pubmed
12204267
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
37459895
uniprot
proteins
sequence_length
335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:37459895}.
uniprot
proteins