Atp6v1b2
entrez
11966
canonical
uniprot
P62814
canonical
ensembl
ENSMUSG00000006273
resolver
ensp
ENSMUSP00000006435
resolver
enst
ENSMUST00000006435
resolver
genesymbol
Atp6v1b2
resolver
genesymbol_syn
Atp6b2
resolver
genesymbol_syn
Vat2
resolver
uniprot
O09045
resolver
uniprot
P50517
resolver
uniprot
Q3TG74
resolver
uniprot
Q3TL62
resolver
uniprot
Q3TVK6
resolver
uniprot
Q3TWR0
resolver
uniprot
Q3U791
resolver
uniprot
Q3U7C8
resolver
uniprot
Q3U9Z0
resolver
uniprot
Q3UAW7
resolver
uniprot_entry
VATB2_MOUSE
resolver
uniprot_sec
O09045
resolver
uniprot_sec
P50517
resolver
uniprot_sec
Q3TG74
resolver
uniprot_sec
Q3TL62
resolver
uniprot_sec
Q3TVK6
resolver
uniprot_sec
Q3TWR0
resolver
uniprot_sec
Q3U791
resolver
uniprot_sec
Q3U7C8
resolver
uniprot_sec
Q3U9Z0
resolver
uniprot_sec
Q3UAW7
resolver
amino_acid_sequence
MALRAMRGIVNGAAPELPVPTGGPMAGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFEKNFITQGPYENRTVYETLDIGWQLLRIFPKEMLKRIPQSTLSEFYPRDSAKH
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:17898041). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (PubMed:17898041). {ECO:0000250|UniProtKB:P21281, ECO:0000269|PubMed:17898041}.
uniprot
proteins
mass_dalton
56551
uniprot
proteins
protein_family
ATPase alpha/beta chains family
uniprot
proteins
pubmed
15013950
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16174750
uniprot
proteins
pubmed
17898041
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24913193
uniprot
proteins
pubmed
29993276
uniprot
proteins
pubmed
8741845
uniprot
proteins
sequence_length
511
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:15013950, ECO:0000269|PubMed:16174750, ECO:0000269|PubMed:17898041, ECO:0000269|PubMed:29993276}. Melanosome {ECO:0000250|UniProtKB:P21281}. Cytoplasm {ECO:0000269|PubMed:15013950, ECO:0000269|PubMed:17898041}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P62815}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P62815}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins