Rspo3
entrez
72780
canonical
uniprot
Q2TJ95
canonical
ensembl
ENSMUSG00000019880
resolver
ensp
ENSMUSP00000090287
resolver
enst
ENSMUST00000092623
resolver
genesymbol
Rspo3
resolver
uniprot
A6H6M4
resolver
uniprot
Q3SYI9
resolver
uniprot
Q5R2V4
resolver
uniprot
Q8BVW2
resolver
uniprot
Q9CSB2
resolver
uniprot_entry
RSPO3_MOUSE
resolver
uniprot_sec
A6H6M4
resolver
uniprot_sec
Q3SYI9
resolver
uniprot_sec
Q5R2V4
resolver
uniprot_sec
Q8BVW2
resolver
uniprot_sec
Q9CSB2
resolver
amino_acid_sequence
MHLRLISCFFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKVDCDTCFNKNFCTKCKSGFYLHLGKCLDSCPEGLEANNHTMECVSIVHCEASEWSPWSPCMKKGKTCGFKRGTETRVRDILQHPSAKGNLCPPTSETRTCIVQRKKCSKGERGKKGRERKRKKLNKEERKETSSSSDSKGLESSIETPDQQENKERQQQQKRRARDKQQKSVSVSTVH
uniprot
proteins
function
FUNCTION: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis (PubMed:16543246, PubMed:21693646, PubMed:26766444). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:16543246, PubMed:21693646). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (PubMed:16543246, PubMed:21693646, PubMed:26766444). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (By similarity). {ECO:0000250|UniProtKB:Q9BXY4, ECO:0000269|PubMed:16543246, ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:26766444}.
uniprot
proteins
mass_dalton
31454
uniprot
proteins
protein_family
R-spondin family
uniprot
proteins
pubmed
15469841
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16543246
uniprot
proteins
pubmed
21693646
uniprot
proteins
pubmed
26766444
uniprot
proteins
sequence_length
277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16543246}.
uniprot
proteins