SLCO4C1
entrez
353189
canonical
uniprot
Q6ZQN7
canonical
ensembl
ENSG00000173930
resolver
ensp
ENSP00000309741
resolver
ensp
ENSP00000563596
resolver
enst
ENST00000310954
resolver
genesymbol
SLCO4C1
resolver
genesymbol_syn
OATP4C1
resolver
genesymbol_syn
OATPX
resolver
genesymbol_syn
SLC21A20
resolver
hgnc
HGNC:23612
resolver
uniprot
Q86UG5
resolver
uniprot_entry
SO4C1_HUMAN
resolver
uniprot_sec
Q86UG5
resolver
amino_acid_sequence
MKSAKGIENLAFVPSSPDILRRLSASPSQIEVSALSSDPQRENSQPQELQKPQEPQKSPEPSLPSAPPNVSEEKLRSLSLSEFEEGSYGWRNFHPQCLQRCNTPGGFLLHYCLLAVTQGIVVNGLVNISISTVEKRYEMKSSLTGLISSSYDISFCLLSLFVSFFGERGHKPRWLAFAAFMIGLGALVFSLPQFFSGEYKLGSLFEDTCVTTRNSTSCTSSTSSLSNYLYVFILGQLLLGAGGTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDVTEDDPRWLGAWWIGFLLSWIFAWSLIIPFSCFPKHLPGTAEIQAGKTSQAHQSNSNADVKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPFAGVSESYNGTGELGNLIAPCNANCNCSRSYYYPVCGDGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIERKTEITSTAETFGFEAKAGKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSILRCVNHRQRSLALGIQFMVLRLLGTIPGPIIFGFTIDSTCILWDINDCGIKGACWIYDNIKMAHMLVAISVTCKVITMFFNGFAIFLYKPPPSATDVSFHKENAVVTNVLAEQDLNKIVKEG
uniprot
proteins
function
FUNCTION: Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney (PubMed:14993604, PubMed:19129463, PubMed:20610891). Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate (PubMed:14993604). Transport is independent of sodium, chloride ion, and ATP (PubMed:14993604). Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter (PubMed:19129463). The driving force for this transport activity is currently not known (By similarity). The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (PubMed:19129463). Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (By similarity). Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)-dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker) (PubMed:30865704). Can act bidirectionally, suggesting a dual protective role of this transport protein; exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) (PubMed:30865704, PubMed:32642843). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells (By similarity). This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation (By similarity). May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity). {ECO:0000250|UniProtKB:Q71MB6, ECO:0000250|UniProtKB:Q8BGD4, ECO:0000269|PubMed:14993604, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20610891, ECO:0000269|PubMed:30865704, ECO:0000269|PubMed:32642843}.
uniprot
proteins
mass_dalton
78948
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14993604
uniprot
proteins
pubmed
19129463
uniprot
proteins
pubmed
20610891
uniprot
proteins
pubmed
30865704
uniprot
proteins
pubmed
32642843
uniprot
proteins
sequence_length
724
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:30865704}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q71MB6}. Note=Detected at the basolateral membrane of the proximal tubule cell in the kidney. {ECO:0000250|UniProtKB:Q71MB6, ECO:0000269|PubMed:30865704}.
uniprot
proteins
transmembrane_region
TRANSMEM 106..126; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 173..197; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 224..254; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 275..295; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 312..336; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 378..399; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 420..443; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 448..471; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 581..603; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 613..638; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 673..690; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins