ARID3C
entrez
138715
canonical
uniprot
A6NKF2
canonical
ensembl
ENSG00000205143
resolver
ensp
ENSP00000368189
resolver
ensp
ENSP00000547040
resolver
enst
ENST00000378909
resolver
genesymbol
ARID3C
resolver
hgnc
HGNC:21209
resolver
uniprot_entry
ARI3C_HUMAN
resolver
amino_acid_sequence
MEALQKQQAARLAQGVGPLAPACPLLPPQPPLPDHRTLQAPEGALGNVGAEEEEDAEEDEEKREEAGAEEEAAEESRPGAQGPSSPSSQPPGLHPHEWTYEEQFKQLYELDADPKRKEFLDDLFSFMQKRGTPVNRVPIMAKQVLDLYALFRLVTAKGGLVEVINRKVWREVTRGLSLPTTITSAAFTLRTQYMKYLYPYECETRALSSPGELQAAIDSNRREGRRQAYTATPLFGLAGPPPRGAQDPALGPGPAPPATQSSPGPAQGSTSGLPAHACAQLSPSPIKKEESGIPNPCLALPVGLALGPTREKLAPEEPPEKRAVLMGPMDPPRPCMPPSFLPRGKVPLREERLDGPLNLAGSGISSINMALEINGVVYTGVLFARRQPVPASQGPTNPAPPPSTGPPSSILP
uniprot
proteins
function
FUNCTION: Transcription factor involved in monocyte-to-macrophage differentiation. Forms a complex with NPM1 to translocate to the nucleus, acting as a transcription factor that promotes the expression of the genes involved in macrophage differentiation, such as STAT3, STAT1 and JUNB. {ECO:0000269|PubMed:38231884}.
uniprot
proteins
mass_dalton
44073
uniprot
proteins
mutagenesis
MUTAGEN 381..385; /note="VLFAR->DLDWG: Strongly decreases interaction with NPM1. Located in cytoplasm and nucleus. Reduced binding to target genes promoters."; /evidence="ECO:0000269|PubMed:38231884
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
17400556
uniprot
proteins
pubmed
38231884
uniprot
proteins
sequence_length
412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:38231884}. Note=Interaction with NPM1 mediates ARID3C nuclear shuttling. {ECO:0000269|PubMed:38231884}.
uniprot
proteins