REEP5
entrez
7905
canonical
uniprot
Q00765
canonical
ensembl
ENSG00000129625
resolver
ensp
ENSP00000368959
resolver
genesymbol
REEP5
resolver
genesymbol_syn
C5orf18
resolver
genesymbol_syn
DP1
resolver
genesymbol_syn
TB2
resolver
hgnc
HGNC:30077
resolver
uniprot
B7Z681
resolver
uniprot
D3DT04
resolver
uniprot
Q04198
resolver
uniprot
Q5QGT0
resolver
uniprot
Q9BWH9
resolver
uniprot_entry
REEP5_HUMAN
resolver
uniprot_sec
B7Z681
resolver
uniprot_sec
D3DT04
resolver
uniprot_sec
Q04198
resolver
uniprot_sec
Q5QGT0
resolver
uniprot_sec
Q9BWH9
resolver
amino_acid_sequence
MSAAMRERFDRFLHEKNCMTDLLAKLEAKTGVNRSFIALGVIGLVALYLVFGYGASLLCNLIGFGYPAYISIKAIESPNKEDDTQWLTYWVVYGVFSIAEFFSDIFLSWFPFYYMLKCGFLLWCMAPSPSNGAELLYKRIIRPFFLKHESQMDSVVKDLKDKAKETADAITKEAKKATVNLLGEEKKST
uniprot
proteins
function
FUNCTION: Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes. {ECO:0000250|UniProtKB:Q60870}.
uniprot
proteins
mass_dalton
21493
uniprot
proteins
protein_family
DP1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15550249
uniprot
proteins
pubmed
1651562
uniprot
proteins
pubmed
16720576
uniprot
proteins
pubmed
1678319
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19665976
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23969831
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
32075961
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23969831}; Multi-pass membrane protein {ECO:0000255}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q60870}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to endoplasmic reticulum tubular network (PubMed:23969831). In cardiomyocytes, localizes to the junctional sarcoplasmic reticulum membrane which is closely tethered to the cell membrane and contractile machinery (By similarity). {ECO:0000250|UniProtKB:Q60870, ECO:0000269|PubMed:23969831}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..51; /note="Helical"; /evidence="ECO:0000305|PubMed:32075961"; TRANSMEM 54..74; /note="Helical"; /evidence="ECO:0000305|PubMed:32075961"; TRANSMEM 85..103; /note="Helical"; /evidence="ECO:0000305|PubMed:32075961"; TRANSMEM 106..123; /note="Helical"; /evidence="ECO:0000305|PubMed:32075961
uniprot
proteins