Map3k15
entrez
270672
canonical
uniprot
A2AQW0
canonical
ensembl
ENSMUSG00000031303
resolver
ensp
ENSMUSP00000033665
resolver
enst
ENSMUST00000033665
resolver
genesymbol
Map3k15
resolver
uniprot_entry
M3K15_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-816, inhibited by phosphorylation at Ser-928 (By similarity). {ECO:0000250|UniProtKB:Q99683}.
uniprot
proteins
amino_acid_sequence
MEGGGGSGGGGGPVPAEAPEEAGEPPQGRLPPGPEGAAGLAEPESTGDAAGGEAEGGRGPRRALRAVYVRSESSQGAAAGGGPEAGALKCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAIVDMSDISRQPSLFYHLGVRESFDMANNVILYYDTDADTALSLKDMVTQKNTASSGNYYFIPYTVTPCADYFCCESDAQRRASEYMQPNWDTILGPLCMPLVDRFTSLLKDIRVTSCAYYKETLLNDIRKAREKYQGDELAKELTRIKFRMDNIEVLTSDIIINLLLSYRDIQDYDAMVKLVETLKMLPTCDLADQHNIKFHYAFALNRRNSTGDREKALQVMLQVLQSCDHPAPDMFCLCGRIYKDIFLDSGCEEDASRDSAIEWYRKGFELQSSLYSGINLAVLLIVSGQQFETSMELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFTVSMLASDIGKAVQAAERLFKLKPPVWYLRSLVQNLLLIQRFKKPITEHSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVYQPSYVSINNEAEERTVSLWHVSPTEMKQIHEWNFTASSIKGISLSKFDERCCFLYVHDNSDDFQIYFSTEDQCNRFCSLVKEMLNNGVGSTVELEGEADGDTLEYEYDHDANGERVVLGKGSYGIVYAGRDLSNQVRIAIKEIPERDIRYSQPLHEEIALHKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSRPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPQKRVTAADLLQEGFLRQVNKGKKNRIAFKPSEGVRSGTGTLALPSSGELVGSSSSEHGSISPDSDAQPDAFFEKVQVPKHQLSHLLSVPDESPALDDRSTALPPEERDPGLFLLRKDSERRAILYRILWEEQNQVASNLQECVVQSSEELLLSVSHIKQIIGILRDFIRSPEHRVMAATISKLKVDLDFDSSSINQIHLILFGFQDAVNRILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELQAHFEPASETEGVDKDTEVEGDYPLVDLLSQEVHVTPRGTRPGSVAIQEGQPHQQDPSLQLSKLRQETNRLWEHLVQKEREYQNLLRLILDQKTQELYHLQLQYKSNGGTENPPPPDGLGTDRELIDWLQLQGVDANTIEKIVEEDYTLSDILNDITKEDLRCLRLRGGVLCRLWHAVSQHRRQMQESSQ
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Serine/threonine kinase which acts as a component of the MAP kinase signal transduction pathway. Once activated, acts as an upstream activator of the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases. May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis. Involved in phosphorylation of WNK4 in response to osmotic stress or hypotonic low-chloride stimulation via the p38 MAPK signal transduction cascade. {ECO:0000250|UniProtKB:Q6ZN16}.
uniprot
proteins
mass_dalton
149327
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1331
uniprot
proteins