Htr6
entrez
15565
canonical
uniprot
Q9R1C8
canonical
ensembl
ENSMUSG00000028747
resolver
ensp
ENSMUSP00000068333
resolver
ensp
ENSMUSP00000101428
resolver
enst
ENSMUST00000068036
resolver
enst
ENSMUST00000105802
resolver
genesymbol
Htr6
resolver
uniprot
Q14AW8
resolver
uniprot_entry
5HT6R_MOUSE
resolver
uniprot_entry
Q14AW8_MOUSE
resolver
amino_acid_sequence
MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTSAPGQCRLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTATAGQALETLQVPRTPRPGMESADSRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRASPASPSMWTSHSGARPGLSLQQVLPLPLPPNSDSDSASGGTSGLQLTAQLLLPGEATRDPPPPTRAPTVVNFFVTDSVEPEIRQHPLGSPMN
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:11406289). Also has a high affinity for tricyclic psychotropic drugs (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (PubMed:25078650). Is an activator of mTOR signaling (PubMed:23027611). {ECO:0000250|UniProtKB:P31388, ECO:0000250|UniProtKB:P50406, ECO:0000269|PubMed:11406289, ECO:0000269|PubMed:23027611, ECO:0000269|PubMed:25078650}.
uniprot
proteins
mass_dalton
46998
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11406289
uniprot
proteins
pubmed
23027611
uniprot
proteins
pubmed
25078650
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P50406}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..52; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P50406"; TRANSMEM 63..88; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P50406"; TRANSMEM 97..122; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P50406"; TRANSMEM 143..167; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P50406"; TRANSMEM 186..209; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P50406"; TRANSMEM 269..295; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P50406"; TRANSMEM 302..325; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P50406
uniprot
proteins