Ran
entrez
19384
canonical
uniprot
P62827
canonical
ensembl
ENSMUSG00000029430
resolver
ensp
ENSMUSP00000031383
resolver
ensp
ENSMUSP00000106975
resolver
enst
ENSMUST00000031383
resolver
enst
ENSMUST00000111343
resolver
genesymbol
Ran
resolver
genesymbol_syn
Rasl2-8
resolver
uniprot
P17080
resolver
uniprot
P28746
resolver
uniprot
P28747
resolver
uniprot
Q3U954
resolver
uniprot
Q811M2
resolver
uniprot
Q86V08
resolver
uniprot
Q9CSP3
resolver
uniprot
Q9CWI7
resolver
uniprot
Q9CZA2
resolver
uniprot
Q9UDJ5
resolver
uniprot
Q9UEU9
resolver
uniprot_entry
RAN_MOUSE
resolver
uniprot_sec
P17080
resolver
uniprot_sec
P28746
resolver
uniprot_sec
P28747
resolver
uniprot_sec
Q3U954
resolver
uniprot_sec
Q811M2
resolver
uniprot_sec
Q86V08
resolver
uniprot_sec
Q9CSP3
resolver
uniprot_sec
Q9CWI7
resolver
uniprot_sec
Q9CZA2
resolver
uniprot_sec
Q9UDJ5
resolver
uniprot_sec
Q9UEU9
resolver
amino_acid_sequence
MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. {ECO:0000250|UniProtKB:P62826}.
uniprot
proteins
mass_dalton
24423
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="T->N: No effect on RANBP10-binding. Loss of interaction with NEMP1."; /evidence="ECO:0000269|PubMed:18347012, ECO:0000269|PubMed:25946333"; MUTAGEN 42; /note="T->A: Loss of interaction with NEMP1."; /evidence="ECO:0000269|PubMed:25946333"; MUTAGEN 69; /note="Q->L: Strongly decreases interaction with RANGRF. Partial decrease in RANBP10-binding. No effect on interaction with NEMP1 and KPNB1."; /evidence="ECO:0000269|PubMed:10811801, ECO:0000269|PubMed:18347012, ECO:0000269|PubMed:25946333
uniprot
proteins
post_translational_modification
PTM: Acetylation by KAT5 at Lys-134 is increased during mitosis, impairs RANGRF binding and enhances RCC1 binding. Acetylation at Lys-37 enhances the association with nuclear export components. Deacetylation of Lys-37 by SIRT7 regulates the nuclear export of NF-kappa-B subunit RELA/p65. {ECO:0000250|UniProtKB:P62826}.
uniprot
proteins
protein_family
Ran family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10500213
uniprot
proteins
pubmed
10811801
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1555775
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18347012
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
25946333
uniprot
proteins
pubmed
26304119
uniprot
proteins
pubmed
7849398
uniprot
proteins
pubmed
7891706
uniprot
proteins
pubmed
8890215
uniprot
proteins
pubmed
9428644
uniprot
proteins
sequence_length
216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18347012, ECO:0000269|PubMed:25946333}. Nucleus envelope {ECO:0000269|PubMed:25946333}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62826}. Cytoplasm {ECO:0000269|PubMed:18347012}. Melanosome {ECO:0000250|UniProtKB:P62826}. Note=Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity). {ECO:0000250|UniProtKB:P62826}.
uniprot
proteins