PALM
entrez
5064
canonical
uniprot
O75781
canonical
ensembl
ENSG00000099864
resolver
ensp
ENSP00000264560
resolver
ensp
ENSP00000341911
resolver
genesymbol
PALM
resolver
genesymbol_syn
KIAA0270
resolver
hgnc
HGNC:8594
resolver
uniprot
O43359
resolver
uniprot
O95673
resolver
uniprot
Q92559
resolver
uniprot
Q9UPJ4
resolver
uniprot
Q9UQS2
resolver
uniprot
Q9UQS3
resolver
uniprot_entry
PALM_HUMAN
resolver
uniprot_sec
O43359
resolver
uniprot_sec
O95673
resolver
uniprot_sec
Q92559
resolver
uniprot_sec
Q9UPJ4
resolver
uniprot_sec
Q9UQS2
resolver
uniprot_sec
Q9UQS3
resolver
amino_acid_sequence
MEVLAAETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEGTPSSASEGDEDLRRQMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPSPVRAPAPSPAKEERKTEVVMNSQQTPVGTPKDKRVSNTPLRTVDGSPMMKAAMYSVEITVEKDKVTGETRVLSSTTLLPRQPLPLGIKVYEDETKVVHAVDGTAENGIHPLSSSEVDELIHKADEVTLSEAGSTAGAAETRGAVEGAARTTPSRREITGVQAQPGEATSGPPGIQPGQEPPVTMIFMGYQNVEDEAETKKVLGLQDTITAELVVIEDAAEPKEPAPPNGSAAEPPTEAASREENQAGPEATTSDPQDLDMKKHRCKCCSIM
uniprot
proteins
function
FUNCTION: Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269|PubMed:14978216}.
uniprot
proteins
mass_dalton
42076
uniprot
proteins
mutagenesis
MUTAGEN 381..383; /note="CKC->SKS: Inhibits axonal and dendritic filopodia formation and reduces axonal and dendritic branching."; /evidence="ECO:0000269|PubMed:14978216
uniprot
proteins
protein_family
Paralemmin family
uniprot
proteins
pubmed
14978216
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16386234
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9039502
uniprot
proteins
pubmed
9615234
uniprot
proteins
pubmed
9813098
uniprot
proteins
sequence_length
387
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14978216}; Lipid-anchor {ECO:0000269|PubMed:14978216}; Cytoplasmic side {ECO:0000269|PubMed:14978216}. Cell projection, filopodium membrane {ECO:0000269|PubMed:14978216}; Lipid-anchor {ECO:0000269|PubMed:14978216}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Apicolateral cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity.
uniprot
proteins