GIGYF2
entrez
26058
canonical
uniprot
Q6Y7W6
canonical
ensembl
ENSG00000204120
resolver
ensp
ENSP00000362664
resolver
ensp
ENSP00000386537
resolver
ensp
ENSP00000387070
resolver
ensp
ENSP00000387170
resolver
genesymbol
GIGYF2
resolver
genesymbol_syn
KIAA0642
resolver
genesymbol_syn
PERQ2
resolver
genesymbol_syn
TNRC15
resolver
hgnc
HGNC:11960
resolver
uniprot
A6H8W4
resolver
uniprot
B9EG55
resolver
uniprot
E9PBB0
resolver
uniprot
O75137
resolver
uniprot
Q7Z2Z8
resolver
uniprot
Q7Z3I2
resolver
uniprot
Q96HU4
resolver
uniprot
Q9NV82
resolver
uniprot_entry
GGYF2_HUMAN
resolver
uniprot_sec
A6H8W4
resolver
uniprot_sec
B9EG55
resolver
uniprot_sec
E9PBB0
resolver
uniprot_sec
O75137
resolver
uniprot_sec
Q7Z2Z8
resolver
uniprot_sec
Q7Z3I2
resolver
uniprot_sec
Q96HU4
resolver
uniprot_sec
Q9NV82
resolver
amino_acid_sequence
MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPSDLLDKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGRPNFEEGGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSAGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHNEEAKEPDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPVPNPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETLDDY
uniprot
proteins
disease_involvement
DISEASE: Parkinson disease 11 (PARK11) [MIM:607688]: A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. {ECO:0000269|PubMed:18358451, ECO:0000269|PubMed:20060621, ECO:0000269|PubMed:20178831, ECO:0000269|PubMed:26134514}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry. Its association with Parkinson disease is however unclear. According to a number of studies, variations affecting this gene are not a frequent cause of Parkinson disease, suggesting that GIGYF2 does not play a major role in Parkinson disease etiology (PubMed:19279319, PubMed:19321232, PubMed:19429085, PubMed:19482505, PubMed:19638301, PubMed:20004041, PubMed:20060621). {ECO:0000269|PubMed:19279319, ECO:0000269|PubMed:19321232, ECO:0000269|PubMed:19429085, ECO:0000269|PubMed:19482505, ECO:0000269|PubMed:19638301, ECO:0000269|PubMed:20004041, ECO:0000269|PubMed:20060621}.
uniprot
proteins
function
FUNCTION: Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}.
uniprot
proteins
mass_dalton
150070
uniprot
proteins
mutagenesis
MUTAGEN 41..49; /note="YRYGREEML->ARAGREEAA: Abolishes interaction with EIF4E2."; /evidence="ECO:0000269|PubMed:22751931"; MUTAGEN 288; /note="W->A: Abolishes interaction with DDX6."; /evidence="ECO:0000269|PubMed:31439631"; MUTAGEN 300; /note="F->A: Abolishes interaction with DDX6; when associated with A-306."; /evidence="ECO:0000269|PubMed:31439631"; MUTAGEN 306; /note="F->A: Abolishes interaction with DDX6; when associated with A-300."; /evidence="ECO:0000269|PubMed:31439631
uniprot
proteins
protein_family
GIGYF family
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12771153
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18358451
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19279319
uniprot
proteins
pubmed
19321232
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19429085
uniprot
proteins
pubmed
19482505
uniprot
proteins
pubmed
19638301
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20004041
uniprot
proteins
pubmed
20060621
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20178831
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22751931
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26134514
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
31439631
uniprot
proteins
pubmed
32726578
uniprot
proteins
pubmed
35878012
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
1299
uniprot
proteins