Psen2
entrez
19165
canonical
uniprot
Q61144
canonical
ensembl
ENSMUSG00000010609
resolver
ensp
ENSMUSP00000010753
resolver
ensp
ENSMUSP00000106733
resolver
ensp
ENSMUSP00000106734
resolver
ensp
ENSMUSP00000106735
resolver
ensp
ENSMUSP00000106737
resolver
enst
ENSMUST00000010753
resolver
enst
ENSMUST00000111104
resolver
enst
ENSMUST00000111105
resolver
enst
ENSMUST00000111106
resolver
enst
ENSMUST00000111108
resolver
genesymbol
Psen2
resolver
genesymbol_syn
Ad4h
resolver
genesymbol_syn
Alg3
resolver
genesymbol_syn
Ps-2
resolver
genesymbol_syn
Ps2
resolver
genesymbol_syn
Psnl2
resolver
uniprot
A0A0R4J1F2
resolver
uniprot
F6X9W8
resolver
uniprot
O54977
resolver
uniprot
P97934
resolver
uniprot
P97935
resolver
uniprot
Q3U4P5
resolver
uniprot
Q91VS3
resolver
uniprot
Q9D616
resolver
uniprot_entry
A0A0R4J1F2_MOUSE
resolver
uniprot_entry
F6X9W8_MOUSE
resolver
uniprot_entry
PSN2_MOUSE
resolver
uniprot_entry
Q3U4P5_MOUSE
resolver
uniprot_sec
O54977
resolver
uniprot_sec
P97934
resolver
uniprot_sec
P97935
resolver
uniprot_sec
Q91VS3
resolver
uniprot_sec
Q9D616
resolver
amino_acid_sequence
MLAFMASDSEEEVCDERTSLMSAESPTSRSCQEGRPGPEDGESTAQWRTQESEEDCEEDPDRYACSGAPGRPSGLEEELTLKYGAKRVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEAFEAPLPGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWNTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI
uniprot
proteins
ec_number
3.4.23.-
uniprot
proteins
function
FUNCTION: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (Probable). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (By similarity). {ECO:0000250|UniProtKB:P49810, ECO:0000269|PubMed:16959576, ECO:0000305|PubMed:19834068}.
uniprot
proteins
mass_dalton
49983
uniprot
proteins
post_translational_modification
PTM: Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments. {ECO:0000250|UniProtKB:P49810}.; PTM: Phosphorylated on serine residues. Phosphorylation at Ser-19 affects PSEN2 sorting. {ECO:0000250|UniProtKB:P49810}.
uniprot
proteins
protein_family
Peptidase A22A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16959576
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19834068
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8560270
uniprot
proteins
pubmed
8940094
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P49810}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P49810}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:P49810}. Lysosome membrane {ECO:0000250|UniProtKB:P49810}. Note=Late endosome/lysosome localization is dependent of the phosphorylation-mediated interaction with the AP1G1 (By similarity). Also highly enriched in mitochondria-associated endoplasmic reticulum membrane contact site (PubMed:19834068). {ECO:0000250|UniProtKB:P49810, ECO:0000269|PubMed:19834068}.
uniprot
proteins
transmembrane_region
TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 250..270; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 359..379; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 389..409; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins