DACH1
entrez
1602
canonical
uniprot
Q9UI36
canonical
ensembl
ENSG00000276644
resolver
ensp
ENSP00000482245
resolver
ensp
ENSP00000482797
resolver
ensp
ENSP00000516321
resolver
genesymbol
DACH1
resolver
genesymbol_syn
DACH
resolver
hgnc
HGNC:2663
resolver
uniprot
A0A087WZP2
resolver
uniprot
D0FY35
resolver
uniprot
D0FY36
resolver
uniprot
O75523
resolver
uniprot
O75687
resolver
uniprot
Q5VYY3
resolver
uniprot
Q5VYY4
resolver
uniprot
Q96SG3
resolver
uniprot
Q96SG4
resolver
uniprot
Q9H524
resolver
uniprot
Q9UMH4
resolver
uniprot_entry
DACH1_HUMAN
resolver
uniprot_sec
A0A087WZP2
resolver
uniprot_sec
D0FY35
resolver
uniprot_sec
D0FY36
resolver
uniprot_sec
O75523
resolver
uniprot_sec
O75687
resolver
uniprot_sec
Q5VYY3
resolver
uniprot_sec
Q5VYY4
resolver
uniprot_sec
Q96SG3
resolver
uniprot_sec
Q96SG4
resolver
uniprot_sec
Q9H524
resolver
uniprot_sec
Q9UMH4
resolver
amino_acid_sequence
MAVPAALIPPTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASAAAAAATVTSTGGGGGGGGSGGGGGSSGNGGGGGGGGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNASSRPGRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPPTGLTAAAAAAAAATNAAIAEAMKVKKIKLEAMSNYHASNNQHGADSENGDMNSSVGSSDGSWDKETLPSSPSQGPQASITHPRMPGARSLPLSHPLNHLQQSHLLPNGLELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAAQVQSPPSRVETSVIKERVPDSPSPAPSLEEGRRPGSHPSSHRSSSVSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHESKRMHIEKDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLFPDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFETKRREQAEQTLKQAASTDSLRVLNDSLTPEIEADRSGGRTDAERTIQDGRLYLKTTVMY
uniprot
proteins
function
FUNCTION: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation also seems to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). {ECO:0000250, ECO:0000269|PubMed:14525983}.
uniprot
proteins
mass_dalton
78562
uniprot
proteins
protein_family
DACH/dachshund family
uniprot
proteins
pubmed
10502110
uniprot
proteins
pubmed
11543628
uniprot
proteins
pubmed
12057194
uniprot
proteins
pubmed
14525983
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9651501
uniprot
proteins
sequence_length
758
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14525983}.
uniprot
proteins