Gpr158
entrez
241263
canonical
uniprot
Q8C419
canonical
ensembl
ENSMUSG00000045967
resolver
ensp
ENSMUSP00000049708
resolver
enst
ENSMUST00000055946
resolver
genesymbol
Gpr158
resolver
genesymbol_syn
Kiaa1136
resolver
uniprot
B1AWY4
resolver
uniprot
Q8CHB0
resolver
uniprot_entry
MGLYR_MOUSE
resolver
uniprot_sec
B1AWY4
resolver
uniprot_sec
Q8CHB0
resolver
amino_acid_sequence
MGAMAYSLLFCLLLAHLGLGEVGASLDPPGRPDSPRERTPRGKQHGQQLPRASAPDPSIPWSRSTDGTILAQKLAEEVPVDVASYLYTGDFHQLKRANCSGRYELAGLPGKSPSLASSHPSLHGALDTLTHATNFLNMMLQSNKSREQTVQDDLQWYQALVRSLLEGEPSISRAAITFSTESLSTPAPQVFLQATREESRILLQDLSSSAHHLANATLETEWFHGLRRKWRPHLHRRGSNQGPRGLGHSWRRRDGLGGDRSHVKWSPPYLECENGSYKPGWLVTLSAAFYGLQPNLVPEFRGVMKVDISLQKVDIDQCSSDGWFSGTHKCHLNNSECMPIKGLGFVLGAYQCICKAGFYHPRVFSVNNFQRRGPDHHFSGSTKDVSEETHVCLPCREGCPFCADDRPCFVQEDKYLRLAIISFQALCMLLDFVSMLVVYHFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTFRCILLRWARLLGFATVYGTVTLKLHRVLKVFLSRTAQRIPYMTGGRVMRMLAVIVLVVFWFLVGWTSSMCQNLERDILLVGQGQTSDHLTFNMCLIDRWDYMTAVAEFLFLLWGIYLCYAVRTVPSAFHEPRYMAVAVHNELIITAIFHTIRFVLASRLQPDWMLMLYFAHAHLTVTVTIGLLLIPKFSHSSNNPRDDIATEAYEDELDMGRSGSYLNSSINSAWSEHSLDPEDIRDELKKLYAQLEIYKRKKMITNNPHLQKKRCSKKGLGRSIMRRITEIPETVSRQCSKEDKEGTDHSAAKGTGLVRKNPTESSGNTGRPKEESLKNRVFSLKKSHSTYDHVRDQTVESSSLPMESQEEEATENSTLESLSSKKLTQKLKEDSEAESTESVPLVCKSASAHNLSSEKKPGHPRTSMLQKSLSVIASAKEKTLGLAGKTQTLVMEDRAKSQKPKDRETIRKYSNSDNVETIPNSGHMEEPRKPQKSGIMKQQRVSLPTANPDVSSGITQIKDNFDIGEVCPWEVYDLTPGPMPSEPKAQKHVSIAASEVEQNPASFLKEKSYHKSKATEGLYQANHKSIDKTEVCPWEIHSQSLLEDENRLISKTPVLPGRAREENGSQLYTTNMCAGQYEELPHKVVAPKVENENLNQMGDQEKQTSSSVDIIPGSCNSSNNSHQPLTSRAEVCPWEFEPLEQPNAERSVTLPASSALSANKIPGPQK
uniprot
proteins
function
FUNCTION: Metabotropic receptor for glycine that controls synapse formation and function in the brain (PubMed:29419376, PubMed:31311860, PubMed:31749686, PubMed:36996198). Acts as an atypical G protein coupled receptor that recruits and regulates the RGS7-GNB5 complex instead of activating G proteins (PubMed:22689652, PubMed:25792749, PubMed:30546127, PubMed:31311860). In absence of glycine ligand, promotes the GTPase activator activity of RGS7, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). Glycine-binding changes the conformation of the intracellular surface, inhibiting the GTPase activator activity of the RGS7-GNB5 complex, promoting G protein alpha subunits into their active GTP-bound form and regulating cAMP levels (By similarity). Also able to bind taurine, a compound closely related to glycine, but with a two-fold lower affinity (By similarity). Glycine receptor-dependent regulation of cAMP controls key ion channels, kinases and neurotrophic factors involved in neuronal excitability and synaptic transmission (PubMed:31311860, PubMed:36996198). Plays a pivotal role in regulating mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (PubMed:28851741, PubMed:29419376, PubMed:30546127, PubMed:31311860, PubMed:31749686). Also involved in spatial learning by regulating hippocampal CA1 neuronal excitability (PubMed:31749686). Acts as a synaptic organizer in the hippocampus, required for proper mossy fiber-CA3 neurocircuitry establishment, structure and function: induces presynaptic differentiation in contacting axons via its interaction with GPC4 (PubMed:30290982). In addition to glycine, may also act as a receptor for osteocalcin (Bglap or Bglap2) hormone: osteocalcin-binding initiates a signaling response that prevents neuronal apoptosis in the hippocampus and regulates the synthesis of neurotransmitters (PubMed:28851741, PubMed:30355501). {ECO:0000250|UniProtKB:Q5T848, ECO:0000269|PubMed:22689652, ECO:0000269|PubMed:25792749, ECO:0000269|PubMed:28851741, ECO:0000269|PubMed:29419376, ECO:0000269|PubMed:30290982, ECO:0000269|PubMed:30355501, ECO:0000269|PubMed:30546127, ECO:0000269|PubMed:31311860, ECO:0000269|PubMed:31749686, ECO:0000269|PubMed:36996198}.
uniprot
proteins
mass_dalton
134426
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
pubmed
12465718
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22689652
uniprot
proteins
pubmed
25792749
uniprot
proteins
pubmed
28851741
uniprot
proteins
pubmed
29419376
uniprot
proteins
pubmed
30282023
uniprot
proteins
pubmed
30290982
uniprot
proteins
pubmed
30355501
uniprot
proteins
pubmed
30546127
uniprot
proteins
pubmed
30855200
uniprot
proteins
pubmed
31311860
uniprot
proteins
pubmed
31749686
uniprot
proteins
pubmed
36634900
uniprot
proteins
pubmed
36979415
uniprot
proteins
pubmed
36996198
uniprot
proteins
sequence_length
1200
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22689652, ECO:0000269|PubMed:25792749, ECO:0000269|PubMed:30546127}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5T848}. Postsynaptic cell membrane {ECO:0000269|PubMed:30290982, ECO:0000269|PubMed:36979415}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5T848}. Presynaptic cell membrane {ECO:0000269|PubMed:36979415}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5T848}. Nucleus {ECO:0000250|UniProtKB:Q5T848}. Note=Mainly localizes to the postsynaptic membrane, with a small portion to the presynaptic membrane (PubMed:36979415). Trafficks between the nucleus and the cell membrane; it is unclear how a multi-pass membrane protein can traffick between the nucleus and the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q5T848, ECO:0000269|PubMed:36979415}.
uniprot
proteins
transmembrane_region
TRANSMEM 418..439; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q5T848"; TRANSMEM 452..474; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q5T848"; TRANSMEM 479..501; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q5T848"; TRANSMEM 526..547; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q5T848"; TRANSMEM 577..597; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q5T848"; TRANSMEM 612..633; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q5T848"; TRANSMEM 643..664; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q5T848
uniprot
proteins