AKTIP
entrez
64400
canonical
uniprot
Q9H8T0
canonical
ensembl
ENSG00000166971
resolver
ensp
ENSP00000378152
resolver
ensp
ENSP00000455874
resolver
ensp
ENSP00000565123
resolver
ensp
ENSP00000565127
resolver
ensp
ENSP00000565133
resolver
ensp
ENSP00000565134
resolver
ensp
ENSP00000607741
resolver
ensp
ENSP00000619890
resolver
ensp
ENSP00000619899
resolver
ensp
ENSP00000766733
resolver
genesymbol
AKTIP
resolver
genesymbol_syn
FTS
resolver
hgnc
HGNC:16710
resolver
uniprot
Q503B1
resolver
uniprot
Q53H38
resolver
uniprot_entry
AKTIP_HUMAN
resolver
uniprot_sec
Q503B1
resolver
uniprot_sec
Q53H38
resolver
amino_acid_sequence
MNPFWSMSTSSVRKRSEGEEKTLTGDVKTSPPRTAPKKQLPSIPKNALPITKPTSPAPAAQSTNGTHASYGPFYLEYSLLAEFTLVVKQKLPGVYVQPSYRSALMWFGVIFIRHGLYQDGVFKFTVYIPDNYPDGDCPRLVFDIPVFHPLVDPTSGELDVKRAFAKWRRNHNHIWQVLMYARRVFYKIDTASPLNPEAAVLYEKDIQLFKSKVVDSVKVCTARLFDQPKIEDPYAISFSPWNPSVHDEAREKMLTQKKPEEQHNKSVHVAGLSWVKPGSVQPFSKEEKTVAT
uniprot
proteins
function
FUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:14749367, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}.
uniprot
proteins
mass_dalton
33128
uniprot
proteins
mutagenesis
MUTAGEN 106..107; /note="WF->AA: Impairs interaction with FHIP1B, HOOK1, HOOK2 and HOOK3."; /evidence="ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997
uniprot
proteins
protein_family
FTS subfamily
uniprot
proteins
protein_family
Ubiquitin-conjugating enzyme family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14749367
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18799622
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
32073997
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14749367}. Cell membrane {ECO:0000269|PubMed:14749367}; Peripheral membrane protein {ECO:0000269|PubMed:14749367}.
uniprot
proteins