Retreg3
entrez
67998
canonical
uniprot
Q9CQV4
canonical
ensembl
ENSMUSG00000017802
resolver
ensp
ENSMUSP00000017946
resolver
ensp
ENSMUSP00000102916
resolver
ensp
ENSMUSP00000171747
resolver
ensp
ENSMUSP00000171755
resolver
genesymbol
Retreg3
resolver
genesymbol_syn
Fam134c
resolver
uniprot
Q3TQL8
resolver
uniprot
Q3U9Q7
resolver
uniprot
Q8BQC4
resolver
uniprot
Q922X3
resolver
uniprot_entry
RETR3_MOUSE
resolver
uniprot_sec
Q3TQL8
resolver
uniprot_sec
Q3U9Q7
resolver
uniprot_sec
Q8BQC4
resolver
uniprot_sec
Q922X3
resolver
amino_acid_sequence
MEEAEGVAAAPGPASGLAFRGRRAMSGSWERDQQVEAAQRTLVEVLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRFVFLLAFSLMIIVCIDQWKNKIWPEINVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNLLLFKKQNPGKFCLLSCGVLTFLAMLGRYIPGLLLSYLMLVIIMMWPLAVYHRLWDRAYVRLKPVLQRLDFSVRGYMMSKQRERQLRRRALHSERATDSHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTENGTFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSINVDPAGLDDEDDTSIGMPSLMYRSPPGAGDTQVLPASRNEAALPELLLSSLPGGSNLTSNLASLVSQGMIQLALSEASQTDPSGPPPRRATRGFLRAPSSDLDTDAEGDDFELLDQSELNQLDPASSRSH
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (By similarity). Required for collagen quality control in a LIR motif-dependent manner (PubMed:34338405). Mediates NRF1-enhanced neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q86VR2, ECO:0000269|PubMed:34338405}.
uniprot
proteins
mass_dalton
51638
uniprot
proteins
mutagenesis
MUTAGEN 447..450; /note="FELL->AELA: Abolishes interaction with ATG8 family proteins."; /evidence="ECO:0000269|PubMed:34338405
uniprot
proteins
protein_family
RETREG family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19838196
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34338405
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q86VR2}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes preferentially to endoplasmic reticulum tubules and sheet edges. {ECO:0000250|UniProtKB:Q86VR2}.
uniprot
proteins
transmembrane_region
TRANSMEM 81..101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 169..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 193..211; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 382..401; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins