SLC13A3
entrez
64849
canonical
uniprot
Q8WWT9
canonical
ensembl
ENSG00000158296
resolver
ensp
ENSP00000279027
resolver
ensp
ENSP00000290317
resolver
ensp
ENSP00000415852
resolver
ensp
ENSP00000420177
resolver
genesymbol
SLC13A3
resolver
genesymbol_syn
NADC3
resolver
genesymbol_syn
SDCT2
resolver
hgnc
HGNC:14430
resolver
uniprot
B4DF27
resolver
uniprot
B4DIR8
resolver
uniprot
E1P5U4
resolver
uniprot
F6WI18
resolver
uniprot
Q5JYC9
resolver
uniprot
Q5JYD0
resolver
uniprot
Q5JYD1
resolver
uniprot
Q5TCQ2
resolver
uniprot
Q8IVB1
resolver
uniprot
Q8N8K4
resolver
uniprot
Q96MM5
resolver
uniprot
Q9BR25
resolver
uniprot
Q9H1G1
resolver
uniprot
Q9H3W4
resolver
uniprot
Q9NQN5
resolver
uniprot
Q9NS04
resolver
uniprot_entry
B4DF27_HUMAN
resolver
uniprot_entry
S13A3_HUMAN
resolver
uniprot_sec
B4DIR8
resolver
uniprot_sec
E1P5U4
resolver
uniprot_sec
F6WI18
resolver
uniprot_sec
Q5JYC9
resolver
uniprot_sec
Q5JYD0
resolver
uniprot_sec
Q5JYD1
resolver
uniprot_sec
Q5TCQ2
resolver
uniprot_sec
Q8IVB1
resolver
uniprot_sec
Q8N8K4
resolver
uniprot_sec
Q96MM5
resolver
uniprot_sec
Q9BR25
resolver
uniprot_sec
Q9H1G1
resolver
uniprot_sec
Q9H3W4
resolver
uniprot_sec
Q9NQN5
resolver
uniprot_sec
Q9NS04
resolver
activity_regulation
ACTIVITY REGULATION: Li(+) decreases succinate transport in the presence of Na(+). {ECO:0000269|PubMed:10794676}.
uniprot
proteins
amino_acid_sequence
MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESEENTAAVRRNGLHTVPTEMQFLASTEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLAGWLWISFLYGGLSFRGWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPGWASLFNPGFLSDAVTGVAIVTILFFFPSQRPSLKWWFDFKAPNTETEPLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTALPPTLANDTFRTL
uniprot
proteins
disease_involvement
DISEASE: Leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate (ARLIAK) [MIM:618384]: An autosomal recessive disorder characterized by acute, reversible neurological deterioration during febrile illness. Patients exhibit reversible leukoencephalopathy and increased urinary excretion of alpha-ketoglutarate. {ECO:0000269|PubMed:30635937}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate (PubMed:10794676, PubMed:10992006, PubMed:15561973, PubMed:17356845, PubMed:17426067, PubMed:24247155, PubMed:30635937, PubMed:39622972). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:10794676, PubMed:10992006). Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood (PubMed:10794676). Imports itaconate in hepatocytes leading to activation of TFEB-dependent lysosomal biogenesis involved in antibacterial innate immune response (PubMed:39116875). {ECO:0000269|PubMed:10794676, ECO:0000269|PubMed:10992006, ECO:0000269|PubMed:15561973, ECO:0000269|PubMed:17356845, ECO:0000269|PubMed:17426067, ECO:0000269|PubMed:24247155, ECO:0000269|PubMed:30635937, ECO:0000269|PubMed:39116875, ECO:0000269|PubMed:39622972}.
uniprot
proteins
mass_dalton
66841
uniprot
proteins
mutagenesis
MUTAGEN 93; /note="F->Y,V,A: Impairs succinate transport."; /evidence="ECO:0000269|PubMed:39622972
uniprot
proteins
protein_family
NADC subfamily
uniprot
proteins
protein_family
SLC13A/DASS transporter (TC 2.A.47) family
uniprot
proteins
pubmed
10794676
uniprot
proteins
pubmed
10992006
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15561973
uniprot
proteins
pubmed
16331647
uniprot
proteins
pubmed
17356845
uniprot
proteins
pubmed
17426067
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
24247155
uniprot
proteins
pubmed
30635937
uniprot
proteins
pubmed
39116875
uniprot
proteins
pubmed
39622972
uniprot
proteins
sequence_length
602
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16331647, ECO:0000269|PubMed:17426067, ECO:0000269|PubMed:39622972}; Multi-pass membrane protein {ECO:0000269|PubMed:16331647, ECO:0000269|PubMed:17426067, ECO:0000269|PubMed:39622972}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..33; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:39622972, ECO:0007744|PDB:8UVC, ECO:0007744|PDB:8UVD, ECO:0007744|PDB:8UVE, ECO:0007744|PDB:8UVF, ECO:0007744|PDB:8UVG, ECO:0007744|PDB:8UVI"; TRANSMEM 36..54; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:39622972, ECO:0007744|PDB:8UVC, ECO:0007744|PDB:8UVD, ECO:0007744|PDB:8UVE, ECO:0007744|PDB:8UVF, ECO:0007744|PDB:8UVG, ECO:0007744|PDB:8UVI"; TRANSMEM 59..72; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:39622972, ECO:0007744|PDB:8UVC, ECO:0007744|PDB:8UVD, ECO:0007744|PDB:8UVE, ECO:0007744|PDB:8UVF, ECO:0007744|PDB:8UVG, ECO:0007744|PDB:8UVI"; TRANSMEM 78..120; /note="Discontinuously helical; Name=4"; /evidence="ECO:0000269|PubMed:39622972, ECO:0007744|PDB:8UVC, ECO:0007744|PDB:8UVD, ECO:0007744|PDB:8UVE, ECO:0007744|PDB:8UVF, ECO:0007744|PDB:8UVG, ECO:0007744|PDB:8UVI"; TRANSMEM 219..266; /note="Discontinuously helical; Name=5"; /evidence="ECO:0000269|PubMed:39622972, ECO:0007744|PDB:8UVC, ECO:0007744|PDB:8UVD, ECO:0007744|PDB:8UVE, ECO:0007744|PDB:8UVF, ECO:0007744|PDB:8UVG, ECO:0007744|PDB:8UVI"; TRANSMEM 275..334; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:39622972, ECO:0007744|PDB:8UVC, ECO:0007744|PDB:8UVD, ECO:0007744|PDB:8UVE, ECO:0007744|PDB:8UVF, ECO:0007744|PDB:8UVG, ECO:0007744|PDB:8UVI"; TRANSMEM 340..357; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:39622972, ECO:0007744|PDB:8UVC, ECO:0007744|PDB:8UVD, ECO:0007744|PDB:8UVE, ECO:0007744|PDB:8UVF, ECO:0007744|PDB:8UVG, ECO:0007744|PDB:8UVI"; TRANSMEM 378..390; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:39622972, ECO:0007744|PDB:8UVC, ECO:0007744|PDB:8UVD, ECO:0007744|PDB:8UVE, ECO:0007744|PDB:8UVF, ECO:0007744|PDB:8UVG, ECO:0007744|PDB:8UVI"; TRANSMEM 418..459; /note="Discontinuously helical; Name=9"; /evidence="ECO:0000269|PubMed:39622972, ECO:0007744|PDB:8UVC, ECO:0007744|PDB:8UVD, ECO:0007744|PDB:8UVE, ECO:0007744|PDB:8UVF, ECO:0007744|PDB:8UVG, ECO:0007744|PDB:8UVI"; TRANSMEM 506..536; /note="Discontinuously helical; Name=10"; /evidence="ECO:0000269|PubMed:39622972, ECO:0007744|PDB:8UVC, ECO:0007744|PDB:8UVD, ECO:0007744|PDB:8UVE, ECO:0007744|PDB:8UVF, ECO:0007744|PDB:8UVG, ECO:0007744|PDB:8UVI"; TRANSMEM 541..571; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:39622972, ECO:0007744|PDB:8UVC, ECO:0007744|PDB:8UVD, ECO:0007744|PDB:8UVE, ECO:0007744|PDB:8UVF, ECO:0007744|PDB:8UVG, ECO:0007744|PDB:8UVI
uniprot
proteins