AGO3
entrez
192669
canonical
uniprot
Q9H9G7
canonical
ensembl
ENSG00000126070
resolver
ensp
ENSP00000246314
resolver
ensp
ENSP00000362287
resolver
ensp
ENSP00000540972
resolver
ensp
ENSP00000651562
resolver
genesymbol
AGO3
resolver
genesymbol_syn
EIF2C3
resolver
hgnc
HGNC:18421
resolver
uniprot
B1ALI0
resolver
uniprot
B4E1P5
resolver
uniprot
Q5TA55
resolver
uniprot
Q9H1U6
resolver
uniprot_entry
AGO3_HUMAN
resolver
uniprot_entry
B4E1P5_HUMAN
resolver
uniprot_sec
B1ALI0
resolver
uniprot_sec
Q5TA55
resolver
uniprot_sec
Q9H1U6
resolver
amino_acid_sequence
MEIGSAGPAGAQPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSIKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA
uniprot
proteins
ec_number
3.1.26.n2
uniprot
proteins
function
FUNCTION: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713). {ECO:0000255|HAMAP-Rule:MF_03032, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:23064648, ECO:0000269|PubMed:29040713}.
uniprot
proteins
mass_dalton
97360
uniprot
proteins
mutagenesis
MUTAGEN 638; /note="E->A: Loss of RNA slicer activity."; /evidence="ECO:0000269|PubMed:29040713
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated on surface-exposed lysines by a SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 during target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs). Ubiquitination by the SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 leads to its subsequent degradation, thereby exposing miRNAs for degradation. ZSWIM8 recognizes and binds AGO3 when it is engaged with a TDMD target. {ECO:0000250|UniProtKB:Q9UKV8}.
uniprot
proteins
protein_family
Ago subfamily
uniprot
proteins
protein_family
Argonaute family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15260970
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16081698
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18771919
uniprot
proteins
pubmed
19167051
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22915799
uniprot
proteins
pubmed
23064648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29040713
uniprot
proteins
sequence_length
860
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000255|HAMAP-Rule:MF_03032, ECO:0000269|PubMed:16081698}.
uniprot
proteins