Pip5k1a
entrez
18720
canonical
uniprot
P70182
canonical
ensembl
ENSMUSG00000028126
resolver
ensp
ENSMUSP00000102851
resolver
ensp
ENSMUSP00000102852
resolver
ensp
ENSMUSP00000102855
resolver
ensp
ENSMUSP00000271104
resolver
genesymbol
Pip5k1a
resolver
uniprot
F8WIX5
resolver
uniprot
Q3U917
resolver
uniprot
Q8K0D3
resolver
uniprot
Q99L80
resolver
uniprot_entry
PI51A_MOUSE
resolver
uniprot_sec
F8WIX5
resolver
uniprot_sec
Q3U917
resolver
uniprot_sec
Q8K0D3
resolver
uniprot_sec
Q99L80
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphatidic acid. {ECO:0000269|PubMed:8798574, ECO:0000269|PubMed:9535851}.
uniprot
proteins
amino_acid_sequence
MASASSGPAAAGFSSLDAGAPAGTAAASGIKRATVSEGPSASVMPVKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELSNSGASGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHMKYDLKGSTYKRRASQKEREKTLPTFKDLDFLQDIPDGLFLDADMYSALCKTLQRDCLVLQSFKIMDYSLLMSIHNMDHAQREPTSNDTQYSADTRRPAPQKALYSTAMESIQGEARRGGTVETEDHMGGIPARNNKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPTKKFRSGPSFSRRSGPSGNSCTSQLMASGEHRAQVTTKAEVEPDVHLGRPDVLPQTPPLEEISEGSPVPGPSFSPVVGQPLQILNLSSTLEKLDVAESEFTH
uniprot
proteins
ec_number
2.7.1.68
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:8798574, PubMed:9535851). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (PubMed:18772378). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (By similarity). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (PubMed:19153220). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (PubMed:19153220). Together with PIP5K1B, is required, after stimulation by G protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (PubMed:18772378). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (By similarity). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (PubMed:27739494). Together with PIP5K1C has a role during embryogenesis (PubMed:20622009). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:10679324). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (By similarity). {ECO:0000250|UniProtKB:Q99755, ECO:0000269|PubMed:10679324, ECO:0000269|PubMed:18772378, ECO:0000269|PubMed:19153220, ECO:0000269|PubMed:20622009, ECO:0000269|PubMed:27739494, ECO:0000269|PubMed:8798574, ECO:0000269|PubMed:9535851, ECO:0000303|PubMed:18772378}.
uniprot
proteins
mass_dalton
60485
uniprot
proteins
pubmed
10679324
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18772378
uniprot
proteins
pubmed
19153220
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20622009
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27739494
uniprot
proteins
pubmed
8798574
uniprot
proteins
pubmed
9535851
uniprot
proteins
sequence_length
546
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20622009}. Cytoplasm {ECO:0000269|PubMed:20622009}. Nucleus {ECO:0000250|UniProtKB:Q99755}. Nucleus speckle {ECO:0000250|UniProtKB:Q99755}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q99755}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q99755}. Note=Colocalizes with RAC1 at actin-rich membrane ruffles (By similarity). Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs (By similarity). {ECO:0000250|UniProtKB:Q99755}.
uniprot
proteins