AOC2
entrez
314
canonical
uniprot
O75106
canonical
ensembl
ENSG00000131480
resolver
ensp
ENSP00000253799
resolver
ensp
ENSP00000406134
resolver
genesymbol
AOC2
resolver
hgnc
HGNC:549
resolver
uniprot
A5PKW2
resolver
uniprot
O00120
resolver
uniprot
O75105
resolver
uniprot
Q4TTW5
resolver
uniprot
Q9UNY0
resolver
uniprot_entry
AOC2_HUMAN
resolver
uniprot_sec
A5PKW2
resolver
uniprot_sec
O00120
resolver
uniprot_sec
O75105
resolver
uniprot_sec
Q4TTW5
resolver
uniprot_sec
Q9UNY0
resolver
amino_acid_sequence
MHLKIVLAFLALSLITIFALAYVLLTSPGGSSQPPHCPSVSHRAQPWPHPGQSQLFADLSREELTAVMRFLTQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPPAREALAIVLFGGQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMWRHLKEVELPKAPIFLSSTFNYNGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFLHPVGLELLLDHRALDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRVPLPPPNGASSLRSRNSPGPLPPLQFSPQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGERIAYEVSVQECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVDIHILVGKGAVQLLPGAVCVFEEAQGLPLRRHHNYLQNHFYGGLASSALVVRSVSSVGNYDYIWDFVLYPNGALEGRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDVAGLKNWVVAEDVVFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASNQTNAWGHQRGYRIQIHSPLGIHIPLESDMERALSWGRYQLVVTQRKEEESQSSSIYHQNDIWTPTVTFADFINNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFFDEDPSIFSPGSVYFEKGQDAGLCSINPVACLPDLAACVPDLPPFSYHGF
uniprot
proteins
ec_number
1.4.3.21
uniprot
proteins
function
FUNCTION: Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:19588076). Has a preference for 2-phenylethylamine, tryptamine and tyramine (PubMed:19588076). Could also act on methylamine and benzylamine but much less efficiently (PubMed:19588076). {ECO:0000269|PubMed:19588076}.
uniprot
proteins
mass_dalton
83673
uniprot
proteins
post_translational_modification
PTM: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. {ECO:0000250|UniProtKB:Q16853}.
uniprot
proteins
protein_family
Copper/topaquinone oxidase family
uniprot
proteins
pubmed
12755418
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17400359
uniprot
proteins
pubmed
19588076
uniprot
proteins
pubmed
9119395
uniprot
proteins
pubmed
9722954
uniprot
proteins
sequence_length
756
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:19588076}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q16853}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19588076}. Note=Either not translocated to the plasma membrane or below detection level. {ECO:0000269|PubMed:19588076}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins