Bfsp1
entrez
12075
canonical
uniprot
A2AMT1
canonical
ensembl
ENSMUSG00000027420
resolver
ensp
ENSMUSP00000028907
resolver
ensp
ENSMUSP00000096899
resolver
genesymbol
Bfsp1
resolver
uniprot
O54770
resolver
uniprot
Q3UPV0
resolver
uniprot
Q6PFF8
resolver
uniprot
Q8BKB1
resolver
uniprot
Q9QWM4
resolver
uniprot_entry
BFSP1_MOUSE
resolver
uniprot_sec
O54770
resolver
uniprot_sec
Q3UPV0
resolver
uniprot_sec
Q6PFF8
resolver
uniprot_sec
Q8BKB1
resolver
uniprot_sec
Q9QWM4
resolver
amino_acid_sequence
MYRRSYVFQARQERYERAQPAGPAAQPGGTAPGLAALQALGERVAVQVQRARALQQRHAGLRRQLDAFQRLGEQPGPEDALARHVEANLQRARDLTAEHARLERQEAEAQRALDEFRSKYENECECQLVLKEMLERLNKEADEALLRNLHLQLEAQFLQADISVAKDRYKKNLLEIQTYITVLQQIVQTAPQVSLVTGMRESGLLMQEKLFTEREVAALQNQLEEGREAVTHLQAQKAELQAQTTALEQAIKHAHECYDEELQLYNEQIENLRKEIEEAERSLERSSYDCRQLAVAQQTLRNELDRYHRIIEIEGSRLSSVFIETPISLITPSHGAPLSLGSSVKDLARAVQDITAAKPRQKALPKSLPKRKEIIAQDKVEETLEDAPLKPPQEPKALQVERKAEGGSQPGAGGGHGVSPTQEGGPEDVPDGGQISKAFGKLCKVVKERVSGHKEPEPEPPTDLFTKGRHVLVTGESSFVDPEFYSSSIPARGGVVISIEEDSMHHDGHVEPSPGQPMPPVENGQGVPQGREGDHSNHQQGTDKNGLRAKEPKDLEEKDDDGKKEAEGSRRPCPVIIPGPDEPSTSHSQTSGSNQGGPVGPASKSSSLLAKGPSKALSIKKVEVVESIEKISTESIQTYEETSVIVETLIGKSKGNKKLGEKSLPDTRA
uniprot
proteins
function
FUNCTION: Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (PubMed:27559293). Involved in altering the calcium regulation of MIP water permeability (By similarity). {ECO:0000250|UniProtKB:Q12934, ECO:0000269|PubMed:27559293}.
uniprot
proteins
mass_dalton
73669
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved during lens cell fiber differentiation with increased fragmentation as fiber cell age increases. {ECO:0000250|UniProtKB:Q06002}.; PTM: [Filensin C-terminal fragment]: Myristoylated at Gly-432 following proteolytic cleavage at Asp-431. {ECO:0000250|UniProtKB:Q06002}.; PTM: [Filensin N-terminal fragment]: Acetylated at Ala-35 following proteolytic cleavage at Leu-34. {ECO:0000250|UniProtKB:Q06002}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
14985306
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19029034
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21745462
uniprot
proteins
pubmed
27559293
uniprot
proteins
pubmed
9409766
uniprot
proteins
pubmed
9651486
uniprot
proteins
sequence_length
669
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19029034}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q06002}; Cytoplasmic side {ECO:0000250|UniProtKB:Q06002}. Cytoplasm {ECO:0000269|PubMed:19029034, ECO:0000269|PubMed:27559293}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q06002}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q06002}.
uniprot
proteins