Pou4f1
entrez
18996
canonical
uniprot
P17208
canonical
ensembl
ENSMUSG00000048349
resolver
ensp
ENSMUSP00000060798
resolver
ensp
ENSMUSP00000232919
resolver
ensp
ENSMUSP00000232920
resolver
genesymbol
Pou4f1
resolver
genesymbol_syn
Brn-3
resolver
genesymbol_syn
Brn3
resolver
genesymbol_syn
Brn3a
resolver
uniprot
E9QPT6
resolver
uniprot_entry
PO4F1_MOUSE
resolver
uniprot_sec
E9QPT6
resolver
amino_acid_sequence
MMSMNSKQPHFAMHPTLPEHKYPSLHSSSEAIRRACLPTPPLQSNLFASLDETLLARAEALAAVDIAVSQGKSHPFKPDATYHTMNSVPCTSTSTVPLAHHHHHHHHHQALEPGDLLDHISSPSLALMAGAGGAGAAGGGGGAHDGPGGGGGPGGGGGPGGGGPGGGGGGGGPGGGGGGPGGGLLGGSAHPHPHMHGLGHLSHPAAAAAMNMPSGLPHPGLVAAAAHHGAAAAAAAAAAGQVAAASAAAAVVGAAGLASICDSDTDPRELEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEGAQREKMNKPELFNGGEKKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKFSATY
uniprot
proteins
function
FUNCTION: Multifunctional transcription factor with different regions mediating its different effects (PubMed:10640682, PubMed:8621561, PubMed:9694219, PubMed:9722627). Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:17668438, PubMed:8621561). Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor (PubMed:12934100). Activates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain) (PubMed:9722627). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins (PubMed:8972215). Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity (PubMed:9448000). May positively regulate POU4F2 and POU4F3 (PubMed:8876243). Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord (PubMed:22326227). Plays a role in TNFSF11-mediated terminal osteoclast differentiation (PubMed:17668438). Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site (PubMed:12441296). {ECO:0000269|PubMed:10640682, ECO:0000269|PubMed:12441296, ECO:0000269|PubMed:12934100, ECO:0000269|PubMed:17668438, ECO:0000269|PubMed:22326227, ECO:0000269|PubMed:8621561, ECO:0000269|PubMed:8876243, ECO:0000269|PubMed:8972215, ECO:0000269|PubMed:9448000, ECO:0000269|PubMed:9694219, ECO:0000269|PubMed:9722627}.; FUNCTION: [Isoform 2]: Able to act as a transcription factor, cannot regulate the expression of the same subset of genes as isoform 1 (PubMed:12934100). Does not have an antiapoptotic effect on neuronal cells (PubMed:9722627). {ECO:0000269|PubMed:12934100, ECO:0000269|PubMed:9722627}.
uniprot
proteins
mass_dalton
42767
uniprot
proteins
mutagenesis
MUTAGEN 378; /note="V->I: Abolishes transcriptional activity. Increases transcriptional repression. Disrupts induction of neurite outgrowth and expression of synaptic genes. No effect on transactivation of BCL2 expression."; /evidence="ECO:0000269|PubMed:8972215, ECO:0000269|PubMed:9694219, ECO:0000269|PubMed:9722627
uniprot
proteins
protein_family
Class-4 subfamily
uniprot
proteins
protein_family
POU transcription factor family
uniprot
proteins
pubmed
10640682
uniprot
proteins
pubmed
12441296
uniprot
proteins
pubmed
12934100
uniprot
proteins
pubmed
17668438
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
1970171
uniprot
proteins
pubmed
22326227
uniprot
proteins
pubmed
8162704
uniprot
proteins
pubmed
8290353
uniprot
proteins
pubmed
8537352
uniprot
proteins
pubmed
8621561
uniprot
proteins
pubmed
8637595
uniprot
proteins
pubmed
8876243
uniprot
proteins
pubmed
8972215
uniprot
proteins
pubmed
9448000
uniprot
proteins
pubmed
9694219
uniprot
proteins
pubmed
9722627
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17668438}. Cytoplasm {ECO:0000269|PubMed:17668438}.
uniprot
proteins