Q6B8I1
uniprot
Q6B8I1
canonical
activity_regulation
ACTIVITY REGULATION: Inhibited by vanadate. {ECO:0000269|PubMed:15252030}.
uniprot
proteins
amino_acid_sequence
MAETSLPELGGEDKATPCPSILELEELLRAGKSSCSRVDEVWPNLFIGDAATANNRFELWKLGITHVLNAAHKGLYCQGGPDFYGSSVSYLGVPAHDLPDFDISAYFSSAADFIHRALNTPGAKVLVHCVVGVSRSATLVLAYLMLHQRLSLRQAVITVRQHRWVFPNRGFLHQLCRLDQQLRGAGQS
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Probable protein tyrosine phosphatase. Has phosphatase activity with synthetic substrates (PubMed:15252030, PubMed:29106959). Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1. {ECO:0000269|PubMed:15252030, ECO:0000269|PubMed:20358250, ECO:0000269|PubMed:29106959}.
uniprot
proteins
mass_dalton
20658
uniprot
proteins
mutagenesis
MUTAGEN 97; /note="D->A: No effect on interaction with MAP3K5."; /evidence="ECO:0000269|PubMed:20358250"; MUTAGEN 129; /note="C->S: Loss of enzyme activity. No effect on interaction with MAP3K5."; /evidence="ECO:0000269|PubMed:20358250, ECO:0000269|PubMed:29106959
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15252030
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20358250
uniprot
proteins
pubmed
29106959
uniprot
proteins
sequence_length
188
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15252030}.
uniprot
proteins