MAGEF1
entrez
64110
canonical
uniprot
Q9HAY2
canonical
ensembl
ENSG00000177383
resolver
ensp
ENSP00000315064
resolver
enst
ENST00000317897
resolver
genesymbol
MAGEF1
resolver
hgnc
HGNC:29639
resolver
uniprot
Q9H215
resolver
uniprot_entry
MAGF1_HUMAN
resolver
uniprot_sec
Q9H215
resolver
amino_acid_sequence
MLQTPESRGLPVPQAEGEKDGGHDGETRAPTASQERPKEELGAGREEGAAEPALTRKGARALAAKALARRRAYRRLNRTVAELVQFLLVKDKKKSPITRSEMVKYVIGDLKILFPDIIARAAEHLRYVFGFELKQFDRKHHTYILINKLKPLEEEEEEDLGGDGPRLGLLMMILGLIYMRGNSAREAQVWEMLRRLGVQPSKYHFLFGYPKRLIMEDFVQQRYLSYRRVPHTNPPEYEFSWGPRSNLEISKMEVLGFVAKLHKKEPQHWPVQYREALADEADRARAKARAEASMRARASARAGIHLW
uniprot
proteins
function
FUNCTION: Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair (PubMed:29225034). {ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:29225034}.
uniprot
proteins
mass_dalton
35222
uniprot
proteins
mutagenesis
MUTAGEN 87..88; /note="Missing: Loss of interaction with NSMCE1."; /evidence="ECO:0000269|PubMed:29225034
uniprot
proteins
pubmed
11313144
uniprot
proteins
pubmed
11454705
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
20864041
uniprot
proteins
pubmed
29225034
uniprot
proteins
sequence_length
307
uniprot
proteins