Enpp7
entrez
303729
canonical
uniprot
Q5EZ72
canonical
ensembl
ENSRNOG00000081693
resolver
ensp
ENSRNOP00000107466
resolver
enst
ENSRNOT00000151666
resolver
genesymbol
Enpp7
resolver
uniprot
A0ABK0LU73
resolver
uniprot_entry
A0ABK0LU73_RAT
resolver
uniprot_entry
ENPP7_RAT
resolver
activity_regulation
ACTIVITY REGULATION: platelet-activating factor hydrolysis is inhibited by higher amount of sphingomyelin (PubMed:16255717). The hydrolysis of platelet-activating factor and sphingomyelin can be inhibited by the presence of sphingomyelin and platelet-activating factor respectively, the inhibition of platelet-activating factor hydrolysis by sphingomyelin being stronger (PubMed:16255717). PAF hydrolysis is dose-dependently increased by both taurocholate (TC) and taurodeoxycholate (TDC) (PubMed:16255717). Hydrolase activity against PAF is inhibited by EDTA and stimulated by 0.1-0.25 mM Zn2+ (PubMed:16255717). {ECO:0000269|PubMed:16255717}.
uniprot
proteins
amino_acid_sequence
MGHSAVLLSVALVILPACVTGGPVQRQQQHKLLLVSFDGFRWNYDQDVETPNLDSMAQEGVKARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMFYNTTNKVRLPYHATLGIQRWWDNGSIPIWITAQRQGLKTGSFFYPGGNVTYQGEAVTMSRKEGVLHNYKNETEWRANVDTVMKWFTEEDVSLVTLYFGEPDSTGHKYGPESQERKDMVKQVDRTVGYLRDSIKRHHLTDSLNLIITSDHGMTTVNKKASDLVEFHKFPNFTFRDIEFELLDYGPNGMLIPKEGMLEKVYSVLKDAHPRLHVYKKEDFPKTFHYANNPRITSLLMYSDLGYVIHGRVNVQFNSGEHGFDNQDMDMKTIFRAVGPSFKAGLEVEPFESVHVYELMCQLLGIVPEPNDGHPGVLQPMLRSGSPLSRQHHLVVVLMGILTGLAKVV
uniprot
proteins
ec_number
3.1.4.12
uniprot
proteins
function
FUNCTION: Choline-specific phosphodiesterase that hydrolyzes sphingomyelin (SM) releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract (PubMed:15708357, PubMed:16255717). Also has phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation. Does not have nucleotide pyrophosphatase activity (PubMed:16255717). May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen (By similarity). {ECO:0000250|UniProtKB:Q3TIW9, ECO:0000269|PubMed:15708357, ECO:0000269|PubMed:16255717}.
uniprot
proteins
mass_dalton
49837
uniprot
proteins
mutagenesis
MUTAGEN 198; /note="D->A: Abolishes the phosphoric diester hydrolase activity against PAF."; /evidence="ECO:0000269|PubMed:16255717"; MUTAGEN 245; /note="D->A: Abolishes the phosphoric diester hydrolase activity against PAF."; /evidence="ECO:0000269|PubMed:16255717
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; required for activity and transport to the plasma membrane. {ECO:0000250|UniProtKB:Q6UWV6}.
uniprot
proteins
protein_family
Nucleotide pyrophosphatase/phosphodiesterase family
uniprot
proteins
pubmed
15205117
uniprot
proteins
pubmed
15708357
uniprot
proteins
pubmed
16255717
uniprot
proteins
sequence_length
439
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15205117}; Single-pass type I membrane protein {ECO:0000269|PubMed:15205117}. Note=The catalytic domain is released into the extracellular medium when cells are treated with trypsin (PubMed:15205117). Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex (By similarity). {ECO:0000250|UniProtKB:Q6UWV6, ECO:0000269|PubMed:15205117}.
uniprot
proteins
transmembrane_region
TRANSMEM 423..439; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins