Q9R037
uniprot
Q9R037
canonical
amino_acid_sequence
MMPLKMCTWGGSYPVGSPGKVGLLSFKETKNTGNKAGNESPVQELRQDVSKKIIECIIEESQKVLQLEDDSLDSKGKGLSDQATASHSVAGTEFSNIPGLLAIQHELQQGSRKADSQNAAEETELETQKCFPSDNNCEKSEKTEDETNNLTEVSSADQLDASKLETEILNKEAVEVKEGDVVNPASSDALSTKDFAAVEEVAPAKPPRHLTPEPDIVASTKKPVPARPPPPTNFPPPRPPPPSRPAPPPRKKKSDLEFEALKTPDLDVPKDNIASDSLLTTNMASESTVRDSLPSLDLASATSGDKIVTAQENGKAPDVQTVAGEVMGPQRPRSNSGRELTDEEILASVMIKNLDTGEEIPLSLAEEKLPTGINPLTPLTLHIMRRTKEYVSNDATQSDDEEKLQSQQTDTDGGRLKQKTTQLKKFLGKSVKRAKHLAEEYGERAINKVKSVRDEVFHTDQDDPSSSDDEGMPYTRPVKFKAAHGFKGPYDFDQIKVVQDLSGEHMGAVWTMKFSHCGRLLASAGQDNIVRIWALKNAFDYFNNMRMKYNTEGRVSPSPSQESLSSSKSDTDMGVCSGTDEDPDDKNAPFRQRPFCKYKGHTADLLDLSWSKNYFLLSSSMDKTVRLWHISRRECLCCFQHIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEHLKYHTQIHVRSTRGRNKVGRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYVNSSSQIKASFSHDFTYLVSGSEDKYVYIWSTYHDLSKFTSVRRDRNDFWEGIKAHNAVVTSAIFAPNPSLMLSLDVQSEKLEGIDKYEDAEVLDNTSTGIVKTDNTEVLLSADFTGAQCFYVKNSFLYP
uniprot
proteins
function
FUNCTION: Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:10464283). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:10464283). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (By similarity). May participate in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (By similarity). {ECO:0000250|UniProtKB:Q5JSH3, ECO:0000269|PubMed:10464283}.
uniprot
proteins
mass_dalton
100948
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ATK1; the phosphorylation stabilizes its interaction with RAB11A and RAB11B. {ECO:0000250|UniProtKB:Q5JSH3}.
uniprot
proteins
pubmed
10464283
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
908
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10464283}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10464283}. Endosome membrane {ECO:0000269|PubMed:10464283}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:10464283}. Note=Colocalized with RAB11 along microtubules oriented toward lamellipodia. {ECO:0000269|PubMed:10464283}.
uniprot
proteins