Rab37
entrez
58222
canonical
uniprot
Q9JKM7
canonical
ensembl
ENSMUSG00000020732
resolver
ensp
ENSMUSP00000021076
resolver
ensp
ENSMUSP00000065016
resolver
ensp
ENSMUSP00000240213
resolver
enst
ENSMUST00000021076
resolver
enst
ENSMUST00000067754
resolver
genesymbol
Rab37
resolver
uniprot
F6W5Z4
resolver
uniprot
F7AQM8
resolver
uniprot
Q544E8
resolver
uniprot
Q8BQX0
resolver
uniprot
Q8C7E1
resolver
uniprot_entry
F6W5Z4_MOUSE
resolver
uniprot_entry
F7AQM8_MOUSE
resolver
uniprot_entry
Q544E8_MOUSE
resolver
uniprot_entry
Q8BQX0_MOUSE
resolver
uniprot_entry
RAB37_MOUSE
resolver
uniprot_sec
Q8C7E1
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including RPGR which promote the exchange of bound GDP for free GTP (PubMed:38536817). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000269|PubMed:38536817, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MTGTPGAATAGDGEAPERSPPFSPNYDLTGKVMLLGDSGVGKTCFLIQFKDGAFLSGTFIATVGIDSRNKVVTVDGARVKLQIWDTAGQERFRSVTHAYYRDAQALLLLYDITNQSSFDNIRAWLTEIHEYAQRDVVIMLLGNKADVSSERVIRSEDGETLAREYGVPFMETSAKTGMNVELAFLAIAKELKYRAGRQPDEPSFQIRDYVESQKKRSSCCSFV
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:38536817). Acts as an organizer for autophagosome biogenesis in a GTP-dependent manner (PubMed:38536817). Involved in retinal homeostasis by autophagy regulation (PubMed:38536817). {ECO:0000269|PubMed:38536817}.
uniprot
proteins
mass_dalton
24656
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10722846
uniprot
proteins
pubmed
12578829
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
38536817
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle. Cell projection, cilium {ECO:0000269|PubMed:38536817}. Note=Secretory granules (PubMed:10722846). Located mainly in the connecting cilia between the outer segment and inner segment and also observed in the outer plexiform layer, inner plexiform layer, and ganglion cell layer of the retinas (PubMed:38536817). {ECO:0000269|PubMed:10722846, ECO:0000269|PubMed:38536817}.
uniprot
proteins