TMEM59L
entrez
25789
canonical
uniprot
Q9UK28
canonical
ensembl
ENSG00000105696
resolver
ensp
ENSP00000262817
resolver
ensp
ENSP00000470879
resolver
enst
ENST00000262817
resolver
enst
ENST00000600490
resolver
genesymbol
TMEM59L
resolver
genesymbol_syn
BSMAP
resolver
genesymbol_syn
C19orf4
resolver
hgnc
HGNC:13237
resolver
uniprot_entry
TM59L_HUMAN
resolver
amino_acid_sequence
MAAVALMPPPLLLLLLLASPPAASAPSARDPFAPQLGDTQNCQLRCRDRDLGPQPSQAGLEGASESPYDRAVLISACERGCRLFSICRFVARSSKPNATQTECEAACVEAYVKEAEQQACSHGCWSQPAEPEPEQKRKVLEAPSGALSLLDLFSTLCNDLVNSAQGFVSSTWTYYLQTDNGKVVVFQTQPIVESLGFQGGRLQRVEVTWRGSHPEALEVHVDPVGPLDKVRKAKIRVKTSSKAKVESEEPQDNDFLSCMSRRSGLPRWILACCLFLSVLVMLWLSCSTLVTAPGQHLKFQPLTLEQHKGFMMEPDWPLYPPPSHACEDSLPPYKLKLDLTKL
uniprot
proteins
function
FUNCTION: Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding. {ECO:0000269|PubMed:20427278}.
uniprot
proteins
mass_dalton
37619
uniprot
proteins
protein_family
TMEM59 family
uniprot
proteins
pubmed
10527841
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20427278
uniprot
proteins
sequence_length
342
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305|PubMed:20427278}; Single-pass type I membrane protein {ECO:0000305|PubMed:20427278}.
uniprot
proteins
transmembrane_region
TRANSMEM 268..290; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins