Tchp
entrez
77832
canonical
uniprot
Q3TVW5
canonical
ensembl
ENSMUSG00000002486
resolver
ensp
ENSMUSP00000092009
resolver
genesymbol
Tchp
resolver
uniprot
Q80ZV6
resolver
uniprot
Q8C459
resolver
uniprot
Q9CTP0
resolver
uniprot_entry
TCHP_MOUSE
resolver
uniprot_sec
Q80ZV6
resolver
uniprot_sec
Q8C459
resolver
uniprot_sec
Q9CTP0
resolver
amino_acid_sequence
MALPTLPSYWSSRKHMDLRQRQHQQEDQFRQQWEQNSRYFRTWDIHNSKQIEWSSKISYQRSMHAYHCEKMKEEKRKILELRRERLRELLLEEQDLLAAELDELRLSMGLREQRLREQHQDLKSAREEQRKLIAERLLYEHWKKNNPKLRELELDLHKKHVINSWATQKEEKKQQEATEKQENKRLENQYAAARREAEARMRVEEERRQLEGRLQAEALRQQMEELKQKEMEATKLKKEQENLLRQRWELERLEEERRQMAALRRKTELGRFLKHQYNAQLNRRTQEIQEELEVDGRILQALLEKEGELQQVELARREQARADAAWMKQVIEEQLQLEKAREAELQQLLREEAKEMWEKREAEWAREQVARDRLMSEVLTGRQQQILEKIEQNRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLARKQELEAQVAERQGQEWEAARQEEEEEEEARQAEEHSNALLQQEAKTMAEKGYQPKLHGHLRIAWD
uniprot
proteins
function
FUNCTION: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). {ECO:0000250|UniProtKB:Q9BT92}.
uniprot
proteins
mass_dalton
60642
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination by the BCR(KCTD17) E3 ubiquitin ligase complex results in proteasomal degradation, and induces ciliogenesis. {ECO:0000250|UniProtKB:Q9BT92}.
uniprot
proteins
protein_family
TCHP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15731013
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
497
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9BT92}. Cytoplasm {ECO:0000250|UniProtKB:Q9BT92}. Cell membrane {ECO:0000250|UniProtKB:Q9BT92}. Mitochondrion {ECO:0000250|UniProtKB:Q9BT92}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9BT92}.
uniprot
proteins