PTP4A2
entrez
8073
canonical
uniprot
Q12974
canonical
ensembl
ENSG00000184007
resolver
ensp
ENSP00000409260
resolver
ensp
ENSP00000473259
resolver
ensp
ENSP00000473490
resolver
ensp
ENSP00000493688
resolver
ensp
ENSP00000497092
resolver
ensp
ENSP00000657667
resolver
genesymbol
PTP4A2
resolver
genesymbol_syn
PRL2
resolver
genesymbol_syn
PTPCAAX2
resolver
hgnc
HGNC:9635
resolver
uniprot
A8K9I8
resolver
uniprot
B4DM39
resolver
uniprot
D3DPP0
resolver
uniprot
E9PGJ6
resolver
uniprot
O00649
resolver
uniprot
Q15197
resolver
uniprot
Q15259
resolver
uniprot
Q15260
resolver
uniprot
Q15261
resolver
uniprot
R4GN50
resolver
uniprot_entry
TP4A2_HUMAN
resolver
uniprot_sec
A8K9I8
resolver
uniprot_sec
B4DM39
resolver
uniprot_sec
D3DPP0
resolver
uniprot_sec
E9PGJ6
resolver
uniprot_sec
O00649
resolver
uniprot_sec
Q15197
resolver
uniprot_sec
Q15259
resolver
uniprot_sec
Q15260
resolver
uniprot_sec
Q15261
resolver
uniprot_sec
R4GN50
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by sodium orthovanadate and pentamidine. {ECO:0000269|PubMed:12516958, ECO:0000269|PubMed:9018080}.
uniprot
proteins
amino_acid_sequence
MNRPAPVEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCVAGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFRDTNGHCCVQ
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. {ECO:0000269|PubMed:14643450}.
uniprot
proteins
mass_dalton
19127
uniprot
proteins
mutagenesis
MUTAGEN 164..167; /note="Missing: Locates in the nucleus and cytosol. No interaction with RABGGTB."; /evidence="ECO:0000269|PubMed:11447212"; MUTAGEN 165; /note="C->S: No effect on interaction with RABGGTB."; /evidence="ECO:0000269|PubMed:11447212
uniprot
proteins
post_translational_modification
PTM: Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB. Unfarnesylated forms are redirected to the nucleus and cytosol.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
10940933
uniprot
proteins
pubmed
11447212
uniprot
proteins
pubmed
11734337
uniprot
proteins
pubmed
12235145
uniprot
proteins
pubmed
12516958
uniprot
proteins
pubmed
14643450
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7490091
uniprot
proteins
pubmed
8529999
uniprot
proteins
pubmed
8661118
uniprot
proteins
pubmed
9018080
uniprot
proteins
sequence_length
167
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane. Early endosome. Cytoplasm.
uniprot
proteins