Ltc4s
entrez
114097
canonical
uniprot
Q925U2
canonical
ensembl
ENSRNOG00000003244
resolver
ensp
ENSRNOP00000004359
resolver
ensp
ENSRNOP00000107331
resolver
enst
ENSRNOT00000173148
resolver
genesymbol
Ltc4s
resolver
uniprot
A0ABK0LZ09
resolver
uniprot
G3V6E6
resolver
uniprot_entry
A0ABK0LZ09_RAT
resolver
uniprot_entry
LTC4S_RAT
resolver
uniprot_sec
G3V6E6
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by MK886. {ECO:0000250|UniProtKB:Q16873}.
uniprot
proteins
amino_acid_sequence
MKEETALLATVTLLGVLLQAYFSLQVISARRTFHVSPPLTSGPPEFERVFRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLFYLFARLRYFQGYARSAQHRLDPLYASARALWLLVAMAALGLLVHFLPGTLRAALFRWLQVLLPMA
uniprot
proteins
ec_number
2.5.1.-
uniprot
proteins
ec_number
4.4.1.20
uniprot
proteins
function
FUNCTION: Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:12445492). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (By similarity). {ECO:0000250|UniProtKB:Q16873, ECO:0000269|PubMed:12445492}.
uniprot
proteins
mass_dalton
16850
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; leukotriene C4 biosynthesis. {ECO:0000250|UniProtKB:Q16873}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-36 by RPS6KB1 inhibits the leukotriene-C4 synthase activity. {ECO:0000250|UniProtKB:Q16873}.
uniprot
proteins
protein_family
MAPEG family
uniprot
proteins
pubmed
12445492
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
150
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000250|UniProtKB:Q16873}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16873}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q16873}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16873}. Nucleus membrane {ECO:0000250|UniProtKB:Q16873}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16873}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q16873"; TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q16873"; TRANSMEM 74..94; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q16873"; TRANSMEM 105..124; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q16873
uniprot
proteins