Grpr
entrez
14829
canonical
uniprot
P21729
canonical
ensembl
ENSMUSG00000031364
resolver
ensp
ENSMUSP00000033730
resolver
enst
ENSMUST00000033730
resolver
genesymbol
Grpr
resolver
uniprot
Q53WV4
resolver
uniprot_entry
GRPR_MOUSE
resolver
uniprot_sec
Q53WV4
resolver
amino_acid_sequence
MAPNNCSHLNLDVDPFLSCNDTFNQSLSPPKMDNWFHPGFIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLAIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLMNRSHSTGRSTTCMTSFKSTNPSATFSLINRNICHEGYV
uniprot
proteins
function
FUNCTION: Receptor for gastrin-releasing peptide (GRP) (PubMed:12526815, PubMed:1671171, PubMed:1707129, PubMed:26658875, PubMed:9345264). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation (PubMed:26658875). Contributes to the regulation of food intake (PubMed:12176666). Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain (PubMed:17653196, PubMed:26658875, PubMed:28280205). Contributes primarily to nonhistaminergic itch sensation (PubMed:28280205). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (PubMed:12526815). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (PubMed:34610277). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425). {ECO:0000269|PubMed:12176666, ECO:0000269|PubMed:12526815, ECO:0000269|PubMed:1671171, ECO:0000269|PubMed:1707129, ECO:0000269|PubMed:17653196, ECO:0000269|PubMed:26658875, ECO:0000269|PubMed:26855425, ECO:0000269|PubMed:34610277, ECO:0000269|PubMed:9345264}.
uniprot
proteins
mass_dalton
43215
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10689196
uniprot
proteins
pubmed
12176666
uniprot
proteins
pubmed
12526815
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1671171
uniprot
proteins
pubmed
1707129
uniprot
proteins
pubmed
17653196
uniprot
proteins
pubmed
26658875
uniprot
proteins
pubmed
26855425
uniprot
proteins
pubmed
28280205
uniprot
proteins
pubmed
34610277
uniprot
proteins
pubmed
8391296
uniprot
proteins
pubmed
9345264
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1671171, ECO:0000269|PubMed:1707129}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..63; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 78..97; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 116..137; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 154..175; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 210..235; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 266..286; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 300..326; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins