PRP4K
entrez
8899
canonical
uniprot
Q13523
canonical
ensembl
ENSG00000112739
resolver
ensp
ENSP00000337194
resolver
ensp
ENSP00000433547
resolver
enst
ENST00000337659
resolver
enst
ENST00000480058
resolver
genesymbol
PRP4K
resolver
genesymbol_syn
KIAA0536
resolver
genesymbol_syn
PRP4
resolver
genesymbol_syn
PRP4B
resolver
genesymbol_syn
PRP4H
resolver
genesymbol_syn
PRPF4K
resolver
hgnc
HGNC:17346
resolver
uniprot
A8K5C9
resolver
uniprot
Q5D0F6
resolver
uniprot
Q5TAY8
resolver
uniprot
Q8IVC3
resolver
uniprot
Q8TDP2
resolver
uniprot
Q96QT7
resolver
uniprot
Q9UEE6
resolver
uniprot_entry
PRP4K_HUMAN
resolver
uniprot_sec
A8K5C9
resolver
uniprot_sec
Q5D0F6
resolver
uniprot_sec
Q5TAY8
resolver
uniprot_sec
Q8IVC3
resolver
uniprot_sec
Q8TDP2
resolver
uniprot_sec
Q96QT7
resolver
uniprot_sec
Q9UEE6
resolver
amino_acid_sequence
MAAAETQSLREQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDKDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKLLAPDMFTESDDMFAAYFDSARLRAAGIGKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}.
uniprot
proteins
mass_dalton
116987
uniprot
proteins
mutagenesis
MUTAGEN 717; /note="K->R: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:29695716
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CLK1 (PubMed:11418604). Autophosphorylated; phosphorylation inhibits interaction with its targets, such as PRPF6 or SMARCA4 (PubMed:12077342). {ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10799319
uniprot
proteins
pubmed
11418604
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
12077342
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17513757
uniprot
proteins
pubmed
17998396
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20118938
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29695716
uniprot
proteins
pubmed
35281802
uniprot
proteins
pubmed
9102632
uniprot
proteins
pubmed
9628581
uniprot
proteins
sequence_length
1007
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12077342}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17998396}. Note=Located throughout the nucleus, excluding the nucleolus but enriched in multiple speckles. {ECO:0000269|PubMed:12077342}.
uniprot
proteins