Trpc4
entrez
22066
canonical
uniprot
Q9QUQ5
canonical
ensembl
ENSMUSG00000027748
resolver
ensp
ENSMUSP00000029311
resolver
ensp
ENSMUSP00000143593
resolver
genesymbol
Trpc4
resolver
genesymbol_syn
Trrp4
resolver
uniprot
Q0VB97
resolver
uniprot
Q62350
resolver
uniprot
Q8BNB6
resolver
uniprot
Q8BNT2
resolver
uniprot
Q9QUQ9
resolver
uniprot
Q9QZC0
resolver
uniprot_entry
Q0VB97_MOUSE
resolver
uniprot_entry
Q8BNB6_MOUSE
resolver
uniprot_entry
Q8BNT2_MOUSE
resolver
uniprot_entry
TRPC4_MOUSE
resolver
uniprot_sec
Q62350
resolver
uniprot_sec
Q9QUQ9
resolver
uniprot_sec
Q9QZC0
resolver
activity_regulation
ACTIVITY REGULATION: May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G protein coupled receptors (By similarity). May be activated by intracellular calcium store depletion (PubMed:11175743). {ECO:0000250|UniProtKB:Q9UBN4, ECO:0000269|PubMed:11175743}.
uniprot
proteins
amino_acid_sequence
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIREAKTEEGLTEENVKELKQDISSFRFEVLGLLRGSKLSTIQSANAASSADSDEKSQSEGNGKDKRKNLSLFDLTTLIHPRSAAIASERHNLSNGSALVVQEPPREKQRKVNFVADIKNFGLFHRRSKQNAAEQNANQIFSVSEEITRQQAAGALERNIELESKGLASRGDRSIPGLNEQCVLVDHRERNTDTLGLQVGKRVCSTFKSEKVVVEDTVPIIPKEKHAHEEDSSIDYDLSPTDTAAHEDYVTTRL
uniprot
proteins
function
FUNCTION: Forms a receptor-activated non-selective calcium permeant cation channel (By similarity). Acts as a cell-cell contact-dependent endothelial calcium entry channel (By similarity). Forms a homomeric ion channel or a heteromeric ion channel with TRPC1; the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel (By similarity). Also permeable to monovalent ions including sodium, lithium and cesium ions (By similarity). {ECO:0000250|UniProtKB:Q9UBN4}.
uniprot
proteins
mass_dalton
111575
uniprot
proteins
protein_family
STrpC subfamily
uniprot
proteins
protein_family
TRPC4 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
10980202
uniprot
proteins
pubmed
11175743
uniprot
proteins
pubmed
19070363
uniprot
proteins
pubmed
20458742
uniprot
proteins
pubmed
32110987
uniprot
proteins
pubmed
7575478
uniprot
proteins
pubmed
9512398
uniprot
proteins
sequence_length
974
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9UBN4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UBN4}.
uniprot
proteins
transmembrane_region
TRANSMEM 363..383; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:Q9UBN4"; TRANSMEM 404..418; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:Q9UBN4"; TRANSMEM 433..453; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:Q9UBN4"; TRANSMEM 476..498; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:Q9UBN4"; TRANSMEM 512..534; /note="Helical; Name=S5"; /evidence="ECO:0000250|UniProtKB:Q9UBN4"; TRANSMEM 600..620; /note="Helical; Name=S6"; /evidence="ECO:0000250|UniProtKB:Q9UBN4
uniprot
proteins