SNRPC
entrez
6631
canonical
uniprot
P09234
canonical
ensembl
ENSG00000124562
resolver
ensp
ENSP00000244520
resolver
enst
ENST00000244520
resolver
genesymbol
SNRPC
resolver
hgnc
HGNC:11157
resolver
uniprot
Q5TAL3
resolver
uniprot
Q5TAL4
resolver
uniprot_entry
Q5TAL4_HUMAN
resolver
uniprot_entry
RU1C_HUMAN
resolver
uniprot_sec
Q5TAL3
resolver
amino_acid_sequence
MPKFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYQKWMEEQAQSLIDKTTAAFQQGKIPPTPFSAPPPAGAMIPPPPSLPGPPRPGMMPAPHMGGPPMMPMMGPPPPGMMPVGPAPGMRPPMGGHMPMMPGPPMMRPPARPMMVPTRPGMTRPDR
uniprot
proteins
function
FUNCTION: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:1826349, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2136774, ECO:0000269|PubMed:8798632}.
uniprot
proteins
mass_dalton
17394
uniprot
proteins
mutagenesis
MUTAGEN 6; /note="C->S: Abolishes the binding to U1 snRNP."; /evidence="ECO:0000269|PubMed:1826349"; MUTAGEN 9; /note="C->S: Abolishes the binding to U1 snRNP."; /evidence="ECO:0000269|PubMed:1826349"; MUTAGEN 24; /note="H->Q: Abolishes the binding to U1 snRNP."; /evidence="ECO:0000269|PubMed:1826349"; MUTAGEN 25; /note="C->S: No effect."; /evidence="ECO:0000269|PubMed:1826349"; MUTAGEN 30; /note="H->Q: Abolishes the binding to U1 snRNP."; /evidence="ECO:0000269|PubMed:1826349
uniprot
proteins
protein_family
U1 small nuclear ribonucleoprotein C family
uniprot
proteins
pubmed
12486009
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15312772
uniprot
proteins
pubmed
15525645
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
1826349
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19325628
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2136774
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25555158
uniprot
proteins
pubmed
2961811
uniprot
proteins
pubmed
2971157
uniprot
proteins
pubmed
8798632
uniprot
proteins
sequence_length
159
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:2136774}.
uniprot
proteins