Hcrtr2
entrez
25605
canonical
uniprot
P56719
canonical
ensembl
ENSRNOG00000011251
resolver
ensembl
ENSRNOG00055007550
resolver
ensembl
ENSRNOG00060018872
resolver
ensembl
ENSRNOG00065017232
resolver
ensp
ENSRNOP00000015824
resolver
ensp
ENSRNOP00000111226
resolver
ensp
ENSRNOP00055010030
resolver
ensp
ENSRNOP00060026619
resolver
ensp
ENSRNOP00065022766
resolver
enst
ENSRNOT00000015824
resolver
enst
ENSRNOT00000127511
resolver
enst
ENSRNOT00055012613
resolver
enst
ENSRNOT00060032616
resolver
enst
ENSRNOT00065028759
resolver
genesymbol
Hcrtr2
resolver
uniprot
A0ABK0M6C8
resolver
uniprot_entry
A0ABK0M6C8_RAT
resolver
uniprot_entry
OX2R_RAT
resolver
amino_acid_sequence
MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that binds neuropeptides orexin-A and orexin-B, two neuropeptides derived from a common precursor, prepro-orexin. Upon neuropeptide ligand binding, HCRTR2 can couple with both G(q)/11 and G(i)/o heterotrimeric G proteins thereby initiating distinct downstream signaling cascades (By similarity). Involved in regulating the sleep-wake cycle. Contributes to central regulation of glucose homeostasis (By similarity). {ECO:0000250|UniProtKB:O43614, ECO:0000250|UniProtKB:P58308}.
uniprot
proteins
mass_dalton
52489
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
9491897
uniprot
proteins
sequence_length
460
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O43614}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O43614}.
uniprot
proteins
transmembrane_region
TRANSMEM 55..75; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O43614"; TRANSMEM 89..110; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O43614"; TRANSMEM 128..150; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O43614"; TRANSMEM 171..191; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O43614"; TRANSMEM 223..243; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O43614"; TRANSMEM 305..326; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O43614"; TRANSMEM 343..366; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:O43614
uniprot
proteins