Obox7
entrez
194588
canonical
uniprot
Q4KL20
canonical
ensembl
ENSMUSG00000055942
resolver
ensp
ENSMUSP00000069239
resolver
ensp
ENSMUSP00000138932
resolver
enst
ENSMUST00000069740
resolver
enst
ENSMUST00000183788
resolver
genesymbol
Obox7
resolver
genesymbol_syn
Gm4745
resolver
uniprot
V9GWX2
resolver
uniprot_entry
OBOX7_MOUSE
resolver
uniprot_sec
V9GWX2
resolver
amino_acid_sequence
MAEGPSLHPKLQVASNIPIEISSQIPQELAKNLPFQMSQSPLVTPGSTMQSSLSVPERNLLQQESEGPSRQSGCMPLSDKYVNKQTGLLASRNFRKERIVYSKEQQRLLQKHFDECQYPKEKKIVELAVLIGVTKMEIKKWFKNNRAKYRQMNLQNIKQALPESNGSSKAVSESTHFPGSIPVVASDNGESICSGTFGEDSIPKFNCSQESSLYCFQA
uniprot
proteins
function
FUNCTION: Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:37459895). Together with other Obox family members, required in early two-cell stage embryos to kick-start the major ZGA wave by facilitating RNA Polymerase II 'pre-configuration', during which RNA Polymerase II relocates from the initial one-cell stage binding targets to ZGA gene promoters and distal enhancers (PubMed:37459895). Mechanistically, promotes recruitment of RNA Polymerase II from (CG-rich) non-ZGA genes to (CG-poor) ZGA genes at the two-cell stage (PubMed:37459895). Binds to regulatory DNA sequences containing a 5'-ACNCCTTTAATCCCAG-3' sequence motif (PubMed:37459895). Most maternal and zygotic Obox family proteins can compensate for one another (PubMed:37459895). {ECO:0000269|PubMed:37459895}.
uniprot
proteins
mass_dalton
24340
uniprot
proteins
protein_family
Obox subfamily
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
37459895
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
uniprot
proteins