Spsb2
entrez
297592
canonical
uniprot
Q5M877
canonical
ensembl
ENSRNOG00000015125
resolver
ensembl
ENSRNOG00055010547
resolver
ensembl
ENSRNOG00060032523
resolver
ensembl
ENSRNOG00065029467
resolver
ensp
ENSRNOP00000020493
resolver
ensp
ENSRNOP00000100710
resolver
ensp
ENSRNOP00055014394
resolver
ensp
ENSRNOP00060046550
resolver
ensp
ENSRNOP00065041838
resolver
enst
ENSRNOT00000020493
resolver
enst
ENSRNOT00000136731
resolver
enst
ENSRNOT00055017871
resolver
enst
ENSRNOT00060056348
resolver
enst
ENSRNOT00065050889
resolver
genesymbol
Spsb2
resolver
genesymbol_syn
Ssb2
resolver
uniprot
A0A8I5ZYR0
resolver
uniprot_entry
A0A8I5ZYR0_RAT
resolver
uniprot_entry
SPSB2_RAT
resolver
amino_acid_sequence
MGQTALARGSSSTPSSHALYSDLSPPEGLEELLSAPPPDLGAQRHHGWNPKDCSENIDVKEGGLCFERRPVAQSTDGVRGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQADHYAALLGSNSESWGWDIGRGKLYHQSKGLEAPQYPAGPQGEQLVVPERLLVVLDMEEGTLGYSIGGTYLGPAFRGLKGRTLYPSVSAVWGQCQVRIRYLGERRAEEPQSLLHLSRLCVRHALGDTRLGQISSLPLPPAMKRYLLYK
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). {ECO:0000250|UniProtKB:Q99619}.
uniprot
proteins
mass_dalton
28797
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
SPSB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
264
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q99619}. Note=Exhibits a diffuse cytosolic localization. {ECO:0000250|UniProtKB:Q99619}.
uniprot
proteins