Krt5
entrez
110308
canonical
uniprot
Q922U2
canonical
ensembl
ENSMUSG00000061527
resolver
ensp
ENSMUSP00000023709
resolver
enst
ENSMUST00000023709
resolver
genesymbol
Krt5
resolver
genesymbol_syn
Krt2-5
resolver
uniprot
Q32P04
resolver
uniprot
Q920F2
resolver
uniprot
Q9CRS6
resolver
uniprot_entry
K2C5_MOUSE
resolver
uniprot_entry
Q32P04_MOUSE
resolver
uniprot_sec
Q920F2
resolver
uniprot_sec
Q9CRS6
resolver
amino_acid_sequence
MSRQSSVSFRSGGSRSFSAASAITPSVSRTSFSSVSRSGGGGGGRISLGGACGAGGYGSRSLYNVGGSKRISYSSGGGSFRNQFGAGGFGFGGGAGSGFGFGGGAGSGFGFGGGAGFGGGYGGAGFPVCPPGGIQEVTVNQNLLTPLNLQIDPTIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWALLQEQGTKTIKQNLDPLFEQYINNLRRQLDGVLGERGRLDSELRNMQDLVEDYKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKVELEARVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRSEIDNVKKQCANLQNAIAEAEQRGELALKDARNKLTELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTNSVSSGYGGGSSIGVGSGFGGGLGSGFAGGLGPRFTRGGGGLGLGSGLSVGGSGFSAGSSQGGMSFGSGGGSGSSVKFVSTTSSSRRSFKS
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in basal keratinocytes of stratified epithelia (PubMed:11408584, PubMed:7539810). Forms heteropolymers with type I partners including KRT14 and KRT15, contributing to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to the basal layer of the epidermis (PubMed:11408584, PubMed:7539810). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (PubMed:19267394). {ECO:0000269|PubMed:11408584, ECO:0000269|PubMed:19267394, ECO:0000269|PubMed:7539810}.
uniprot
proteins
mass_dalton
61767
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="T->A: Decreases phosphorylation by CDK1."; /evidence="ECO:0000269|PubMed:29518391"; MUTAGEN 31; /note="S->A: Decreases phosphorylation by AURKB."; /evidence="ECO:0000269|PubMed:29518391"; MUTAGEN 145; /note="T->A: Decreases phosphorylation by CDK1."; /evidence="ECO:0000269|PubMed:29518391"; MUTAGEN 160; /note="T->A: Decreases phosphorylation by AURKB."; /evidence="ECO:0000269|PubMed:29518391
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK1, AURKB and Rho-kinase, phosphorylation is regulated by the cell cycle (PubMed:29518391). Thr-24 phosphorylation, mediated by CDK1, peaks during prometaphase or metaphase cells with phosphorylated filamentous structures evident throughout the cytoplasm during early mitosis (PubMed:29518391). CDK1 phosphorylates Thr-24 in mitotic cells at the site of injury (PubMed:29518391). {ECO:0000269|PubMed:29518391}.; PTM: O-glycosylated. {ECO:0000269|PubMed:12657653}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
11408584
uniprot
proteins
pubmed
12657653
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18285451
uniprot
proteins
pubmed
19267394
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24751727
uniprot
proteins
pubmed
24940650
uniprot
proteins
pubmed
26758872
uniprot
proteins
pubmed
29518391
uniprot
proteins
pubmed
32758484
uniprot
proteins
pubmed
7539810
uniprot
proteins
sequence_length
580
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12657653, ECO:0000269|PubMed:29518391}.
uniprot
proteins