POFUT3
entrez
84750
canonical
uniprot
Q6P4F1
canonical
ensembl
ENSG00000172728
resolver
ensp
ENSP00000332757
resolver
genesymbol
POFUT3
resolver
genesymbol_syn
FUT10
resolver
hgnc
HGNC:19234
resolver
uniprot
A8KAC8
resolver
uniprot
Q70GG3
resolver
uniprot
Q8IVI6
resolver
uniprot
Q8IVI7
resolver
uniprot
Q8IVJ3
resolver
uniprot
Q8TE43
resolver
uniprot
Q9BSR3
resolver
uniprot_entry
OFUT3_HUMAN
resolver
uniprot_sec
A8KAC8
resolver
uniprot_sec
Q70GG3
resolver
uniprot_sec
Q8IVI6
resolver
uniprot_sec
Q8IVI7
resolver
uniprot_sec
Q8IVJ3
resolver
uniprot_sec
Q8TE43
resolver
uniprot_sec
Q9BSR3
resolver
amino_acid_sequence
MVRIQRRKLLASCLCVTATVFLLVTLQVMVELGKFERKEFKSSSLQDGHTKMEEAPTHLNSFLKKEGLTFNRKRKWELDSYPIMLWWSPLTGETGRLGQCGADACFFTINRTYLHHHMTKAFLFYGTDFNIDSLPLPRKAHHDWAVFHEESPKNNYKLFHKPVITLFNYTATFSRHSHLPLTTQYLESIEVLKSLRYLVPLQSKNKLRKRLAPLVYVQSDCDPPSDRDSYVRELMTYIEVDSYGECLRNKDLPQQLKNPASMDADGFYRIIAQYKFILAFENAVCDDYITEKFWRPLKLGVVPVYYGSPSITDWLPSNKSAILVSEFSHPRELASYIRRLDSDDRLYEAYVEWKLKGEISNQRLLTALRERKWGVQDVNQDNYIDAFECMVCTKVWANIRLQEKGLPPKRWEAEDTHLSCPEPTVFAFSPLRTPPLSSLREMWISSFEQSKKEAQALRWLVDRNQNFSSQEFWGLVFKD
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.1.221
uniprot
proteins
function
FUNCTION: Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1 (PubMed:39775168). Attaches fucose through an O-glycosidic linkage (PubMed:39775168). O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion (PubMed:39775168). May also show alpha-(1,3)-fucosyltransferase activity toward the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors (PubMed:19088067). However, this was tested with a library of synthetic substrates and this activity is unsure in vivo (PubMed:19088067). May be involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (By similarity). {ECO:0000250|UniProtKB:Q5F2L2, ECO:0000269|PubMed:19088067, ECO:0000269|PubMed:39775168}.
uniprot
proteins
mass_dalton
56094
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:19088067, ECO:0000269|PubMed:39775168}.
uniprot
proteins
protein_family
Glycosyltransferase 10 family
uniprot
proteins
pubmed
11698403
uniprot
proteins
pubmed
12370785
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19088067
uniprot
proteins
pubmed
39775168
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:39775168}; Single-pass type II membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000305|PubMed:19088067}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000305|PubMed:12370785, ECO:0000305|PubMed:19088067}; Single-pass type II membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 4]: Golgi apparatus {ECO:0000269|PubMed:19088067}. Lysosome {ECO:0000269|PubMed:19088067}.; SUBCELLULAR LOCATION: [Isoform 5]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19088067}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000305|PubMed:19088067}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..31; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins