ABCC11
entrez
85320
canonical
uniprot
Q96J66
canonical
ensembl
ENSG00000121270
resolver
ensp
ENSP00000311326
resolver
ensp
ENSP00000349017
resolver
ensp
ENSP00000378230
resolver
ensp
ENSP00000378231
resolver
genesymbol
ABCC11
resolver
genesymbol_syn
MRP8
resolver
hgnc
HGNC:14639
resolver
uniprot
Q8TDJ0
resolver
uniprot
Q96JA6
resolver
uniprot
Q9BX80
resolver
uniprot_entry
MRP8_HUMAN
resolver
uniprot_sec
Q8TDJ0
resolver
uniprot_sec
Q96JA6
resolver
uniprot_sec
Q9BX80
resolver
amino_acid_sequence
MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSSLR
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
ec_number
7.6.2.3
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Plays a role in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides, including cAMP and cGMP (PubMed:12764137, PubMed:15537867). Mediates the ATP-dependent efflux of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates, such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:16359813, PubMed:25896536). Plays a role in the transport of earwax components (PubMed:16444273, PubMed:19383836). Participates in the secretion of odorants and their precursors from the apocrine sweat glands, including the secretion of glutamine conjugates, as well as the Cys-Gly-(S) conjugates of 3-methyl-3-sulfanyl-hexanol (PubMed:19710689). Involved in the cellular extrusion of nucleotide analogs, hence conferring resistance to various drugs, including clinically relevant drugs such as 5-fluorouracil (5-FU) and methotrexate (PubMed:12764137, PubMed:15537867, PubMed:25896536). {ECO:0000269|PubMed:12764137, ECO:0000269|PubMed:15537867, ECO:0000269|PubMed:16359813, ECO:0000269|PubMed:16444273, ECO:0000269|PubMed:19383836, ECO:0000269|PubMed:19710689, ECO:0000269|PubMed:25896536}.
uniprot
proteins
mass_dalton
154301
uniprot
proteins
mutagenesis
MUTAGEN 180; /note="G->A,P: Does not affect N-glycosylation."; /evidence="ECO:0000269|PubMed:19383836"; MUTAGEN 180; /note="G->H,D,E,K: Loss of N-glycosylation."; /evidence="ECO:0000269|PubMed:19383836"; MUTAGEN 838; /note="N->Q: Loss of N-glycosylation."; /evidence="ECO:0000269|PubMed:19383836"; MUTAGEN 844; /note="N->Q: Loss of N-glycosylation."; /evidence="ECO:0000269|PubMed:19383836
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCC family
uniprot
proteins
protein_family
Conjugate transporter (TC 3.A.1.208) subfamily
uniprot
proteins
pubmed
11483364
uniprot
proteins
pubmed
11591886
uniprot
proteins
pubmed
11688999
uniprot
proteins
pubmed
12764137
uniprot
proteins
pubmed
15537867
uniprot
proteins
pubmed
16359813
uniprot
proteins
pubmed
16444273
uniprot
proteins
pubmed
19383836
uniprot
proteins
pubmed
19710689
uniprot
proteins
pubmed
20937735
uniprot
proteins
pubmed
25896536
uniprot
proteins
sequence_length
1382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19383836, ECO:0000269|PubMed:25896536}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000269|PubMed:19383836}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:25896536}. Apical cell membrane {ECO:0000269|PubMed:16359813}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 164..184; /note="Helical; Name=1"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 195..215; /note="Helical; Name=2"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 271..291; /note="Helical; Name=3"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 297..317; /note="Helical; Name=4"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 384..404; /note="Helical; Name=5"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 418..438; /note="Helical; Name=6"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 807..827; /note="Helical; Name=7"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 864..884; /note="Helical; Name=8"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 931..951; /note="Helical; Name=9"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 952..972; /note="Helical; Name=10"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1050..1070; /note="Helical; Name=11"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1075..1095; /note="Helical; Name=12"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins