RPAP2
entrez
79871
canonical
uniprot
Q8IXW5
canonical
ensembl
ENSG00000122484
resolver
ensp
ENSP00000476948
resolver
ensp
ENSP00000685634
resolver
ensp
ENSP00000791232
resolver
genesymbol
RPAP2
resolver
genesymbol_syn
C1orf82
resolver
hgnc
HGNC:25791
resolver
uniprot
C9JKB5
resolver
uniprot
Q49AS7
resolver
uniprot
Q9H8Y2
resolver
uniprot_entry
RPAP2_HUMAN
resolver
uniprot_sec
C9JKB5
resolver
uniprot_sec
Q49AS7
resolver
uniprot_sec
Q9H8Y2
resolver
amino_acid_sequence
MADFAGPSSAGRKAGAPRCSRKAAGTKQTSTLKQEDASKRKAELEAAVRKKIEFERKALHIVEQLLEENITEEFLMECGRFITPAHYSDVVDERSIVKLCGYPLCQKKLGIVPKQKYKISTKTNKVYDITERKSFCSNFCYQASKFFEAQIPKTPVWVREEERHPDFQLLKEEQSGHSGEEVQLCSKAIKTSDIDNPSHFEKQYESSSSSTHSDSSSDNEQDFVSSILPGNRPNSTNIRPQLHQKSIMKKKAGHKANSKHKDKEQTVVDVTEQLGDCKLDSQEKDATCELPLQKVNTQSSSNSTLPERLKASENSESEYSRSEITLVGISKKSAEHFKRKFAKSNQVSRSVSSSVQVCPEVGKRNLLKVLKETLIEWKTEETLRFLYGQNYASVCLKPEASLVKEELDEDDIISDPDSHFPAWRESQNSLDESLPFRGSGTAIKPLPSYENLKKETEKLNLRIREFYRGRYVLGEETTKSQDSEEHDSTFPLIDSSSQNQIRKRIVLEKLSKVLPGLLVPLQITLGDIYTQLKNLVRTFRLTNRNIIHKPAEWTLIAMVLLSLLTPILGIQKHSQEGMVFTRFLDTLLEELHLKNEDLESLTIIFRTSCLPE
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (PubMed:17643375, PubMed:22137580, PubMed:24997600). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:30118681). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:22137580, ECO:0000269|PubMed:24997600, ECO:0000269|PubMed:30118681}.
uniprot
proteins
mass_dalton
69509
uniprot
proteins
mutagenesis
MUTAGEN 2..32; /note="Missing: Abolishes dephosphorylation of ERN1; when associated with 275-G--E-612 DEL."; /evidence="ECO:0000269|PubMed:30118681"; MUTAGEN 100; /note="C->A: Abolishes interaction with RNA polymerase II complex subunits; when associated with A-105."; /evidence="ECO:0000269|PubMed:22137580"; MUTAGEN 105; /note="C->A: Abolishes interaction with RNA polymerase II complex subunits; when associated with A-100."; /evidence="ECO:0000269|PubMed:22137580"; MUTAGEN 136; /note="C->A: Abolishes interaction with RNA polymerase II complex subunits; when associated with A-140."; /evidence="ECO:0000269|PubMed:22137580"; MUTAGEN 140; /note="C->A: Abolishes interaction with RNA polymerase II complex subunits; when associated with A-136."; /evidence="ECO:0000269|PubMed:22137580"; MUTAGEN 275..612; /note="Missing: Abolishes dephosphorylation of ERN1; when associated with 2-A--L-32 DEL."; /evidence="ECO:0000269|PubMed:30118681
uniprot
proteins
protein_family
RPAP2 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17643375
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22137580
uniprot
proteins
pubmed
22231121
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24997600
uniprot
proteins
pubmed
30118681
uniprot
proteins
sequence_length
612
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22137580}. Nucleus {ECO:0000269|PubMed:22137580}. Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner.
uniprot
proteins