PDIA6
entrez
10130
canonical
uniprot
Q15084
canonical
ensembl
ENSG00000143870
resolver
ensp
ENSP00000272227
resolver
ensp
ENSP00000371024
resolver
ensp
ENSP00000384459
resolver
ensp
ENSP00000385385
resolver
ensp
ENSP00000438778
resolver
ensp
ENSP00000646854
resolver
genesymbol
PDIA6
resolver
genesymbol_syn
ERP5
resolver
genesymbol_syn
P5
resolver
genesymbol_syn
TXNDC7
resolver
hgnc
HGNC:30168
resolver
uniprot
A0A384NPU5
resolver
uniprot
B3KY95
resolver
uniprot
B5MCQ5
resolver
uniprot
B7Z254
resolver
uniprot
B7Z4M8
resolver
uniprot
F8WA83
resolver
uniprot
Q53RC7
resolver
uniprot
Q6ZSH5
resolver
uniprot
Q99778
resolver
uniprot_entry
A0A384NPU5_HUMAN
resolver
uniprot_entry
PDIA6_HUMAN
resolver
uniprot_sec
B3KY95
resolver
uniprot_sec
B5MCQ5
resolver
uniprot_sec
B7Z254
resolver
uniprot_sec
B7Z4M8
resolver
uniprot_sec
F8WA83
resolver
uniprot_sec
Q53RC7
resolver
uniprot_sec
Q6ZSH5
resolver
uniprot_sec
Q99778
resolver
amino_acid_sequence
MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDDLGKDEL
uniprot
proteins
ec_number
5.3.4.1
uniprot
proteins
function
FUNCTION: May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}.
uniprot
proteins
mass_dalton
48121
uniprot
proteins
mutagenesis
MUTAGEN 55; /note="C->S: 50% decrease in enzyme activity; when associated with S-58. Abolishes enzyme activity; when associated with S-58; S-190 and S-193."; /evidence="ECO:0000269|PubMed:12204115"; MUTAGEN 58; /note="C->A: Accelerates dephosphorylation of ERN1; when associated with A-193."; /evidence="ECO:0000269|PubMed:24508390"; MUTAGEN 58; /note="C->S: 50% decrease in enzyme activity; when associated with S-55. 90% decrease in enzyme activity; when associated with S-193. Abolishes enzyme activity; when associated with S-55; S-190 and S-193."; /evidence="ECO:0000269|PubMed:12204115"; MUTAGEN 190; /note="C->S: 25% decrease in enzyme activity; when associated with S-193. Abolishes enzyme activity; when associated with S-55; S-58 and S-193."; /evidence="ECO:0000269|PubMed:12204115"; MUTAGEN 193; /note="C->A: Accelerates dephosphorylation of ERN1; when associated with A-58."; /evidence="ECO:0000269|PubMed:24508390"; MUTAGEN 193; /note="C->S: 90% decrease in enzyme activity; when associated with S-58. 25% decrease in enzyme activity; when associated with S-190. Abolishes enzyme activity; when associated with S-55; S-58 and S-190."; /evidence="ECO:0000269|PubMed:12204115
uniprot
proteins
protein_family
Protein disulfide isomerase family
uniprot
proteins
pubmed
12204115
uniprot
proteins
pubmed
12475965
uniprot
proteins
pubmed
12643545
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15466936
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17495932
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19892738
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24508390
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
7590364
uniprot
proteins
pubmed
9110174
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:15466936}. Cell membrane {ECO:0000269|PubMed:15466936}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). {ECO:0000269|PubMed:12643545}.
uniprot
proteins