Slc7a13
entrez
74087
canonical
uniprot
Q91WN3
canonical
ensembl
ENSMUSG00000041052
resolver
ensp
ENSMUSP00000036228
resolver
enst
ENSMUST00000035890
resolver
genesymbol
Slc7a13
resolver
genesymbol_syn
Agt1
resolver
genesymbol_syn
Xat2
resolver
uniprot_entry
S7A13_MOUSE
resolver
amino_acid_sequence
MAMDSKKEIRLKRELGYFWGTNFLIINIIGAGIFVSPKGVLQHSSMNVGVSLCVWAVCAVLTLTSALCSAEIGITFPYSGAHYYFLKRCFGPLVAFLRLWTSLFLGPGLIASQALLLAEYGVQPFYPSCSAPILPRKCLALAMLWIVGILNSRGVKELSWLQTVSSVLKVGILGVISLSGLFLLVRGKKENVQRLQNAFDAEFPEVSQLIEAIFQGYFAFSGGGCFTCIAGELKKPSKTIPRCIFTGLPLVTVVYLLANISYLTVLTPQEMLSSDAVALTWTDRVIPQFTWTVPFAISASLFINLVINVLETSRVLYIASENGQLPLLFCALNVHSSPFIAVLLIISMASILIVLTNLIDLINYLYFVVSIWTALSIIGILKLRYQEPNLHRPYKVFLPFTFIALGITLSLVLIPLVKSPKLHYIYVFLFLLSGLVFYVPLIHFKVKFVWFQKLTCYLQLLFNICIPDVSDDHIHEES
uniprot
proteins
function
FUNCTION: Associates with SLC3A1/rBAT to form a functional heterodimeric complex that transports anionic and neutral amino acids across the apical plasma membrane of renal epithelium. Preferentially mediates exchange transport, but can also operate via facilitated diffusion. May act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate. {ECO:0000269|PubMed:11907033, ECO:0000269|PubMed:26739563}.
uniprot
proteins
mass_dalton
53233
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
pubmed
11907033
uniprot
proteins
pubmed
11943479
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26739563
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:26739563}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..35; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 48..68; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 130..150; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 164..184; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 209..229; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 243..263; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 339..359; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 361..381; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 396..416; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 424..444; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins