QNG1
entrez
84267
canonical
uniprot
Q5T6V5
canonical
ensembl
ENSG00000165118
resolver
ensp
ENSP00000318375
resolver
ensp
ENSP00000365522
resolver
enst
ENST00000314700
resolver
enst
ENST00000376344
resolver
genesymbol
QNG1
resolver
genesymbol_syn
C9orf64
resolver
hgnc
HGNC:28144
resolver
uniprot
B2RPI6
resolver
uniprot
Q5T6V7
resolver
uniprot
Q8N2B1
resolver
uniprot
Q9BT18
resolver
uniprot_entry
Q5T6V7_HUMAN
resolver
uniprot_entry
QNG1_HUMAN
resolver
uniprot_sec
B2RPI6
resolver
uniprot_sec
Q8N2B1
resolver
uniprot_sec
Q9BT18
resolver
amino_acid_sequence
MDGLLNPRESSKFIAENSRDVFIDSGGVRRVAELLLAKAAGPELRVEGWKALHELNPRAADEAAVNWVFVTDTLNFSFWSEQDEHKCVVRYRGKTYSGYWSLCAAVNRALDEGIPITSASYYATVTLDQVRNILRSDTDVSMPLVEERHRILNETGKILLEKFGGSFLNCVRESENSAQKLMHLVVESFPSYRDVTLFEGKRVSFYKRAQILVADTWSVLEGKGDGCFKDISSITMFADYRLPQVLAHLGALKYSDDLLKKLLKGEMLSYGDRQEVEIRGCSLWCVELIRDCLLELIEQKGEKPNGEINSILLDYYLWDYAHDHREDMKGIPFHRIRCIYY
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. In vitro, can also catalyze the release of the q base directly from Q as substrate; however, it was shown that Q is not the biologically relevant substrate. Shows a very low activity on queuosine 3',5'-diphosphate, and cannot release q from queuosine 3'-phosphate and from the 5'-nucleotides AMP, UMP, CMP or GMP, indicating specificity for the queuine base (PubMed:36610787). Can complement the yeast mutant SPAC589.05c, restoring Q incorporation into tRNA (PubMed:24911101). {ECO:0000269|PubMed:24911101, ECO:0000269|PubMed:36610787}.
uniprot
proteins
mass_dalton
39029
uniprot
proteins
protein_family
QNG1 protein family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24911101
uniprot
proteins
pubmed
36610787
uniprot
proteins
sequence_length
341
uniprot
proteins