Tmem217
entrez
71138
canonical
uniprot
Q14AF1
canonical
ensembl
ENSMUSG00000079580
resolver
ensp
ENSMUSP00000110331
resolver
ensp
ENSMUSP00000132463
resolver
ensp
ENSMUSP00000156979
resolver
ensp
ENSMUSP00000157082
resolver
ensp
ENSMUSP00000157370
resolver
enst
ENSMUST00000114683
resolver
enst
ENSMUST00000168339
resolver
enst
ENSMUST00000234718
resolver
enst
ENSMUST00000234979
resolver
enst
ENSMUST00000235062
resolver
genesymbol
Tmem217
resolver
genesymbol_syn
4933413N12Rik
resolver
uniprot
A0A3Q4EIJ5
resolver
uniprot_entry
A0A3Q4EIJ5_MOUSE
resolver
uniprot_entry
Q14AF1_MOUSE
resolver
amino_acid_sequence
MKHHSWCGLTARMGTVLSGVFSIMATHMHLIFERKHLGNGNCTENFQAQGLNILRYFFICWSFQIVLFTSIITMIASCFLLYSVYAQIYEGLMSYVIWIIIYESTSLTVQTLTDEFSVALVRAMRWFGWVSRASLHCFWLYFVVTHAQIIYQSKKQGNILTYHRRISLGSGDRPRRKSKIIHFVQHHSE
uniprot
proteins
function
FUNCTION: Transmembrane protein essential for sperm motility and male fertility (PubMed:41091759). Forms a complex with SLC9C1 in the flagellum, which regulates sperm motility by maintaining the stability of soluble adenylyl cyclase (ADCY10), which produces cAMP to power flagellar movement (PubMed:41091759). {ECO:0000269|PubMed:41091759}.
uniprot
proteins
mass_dalton
22084
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
41091759
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:41091759}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in the principal piece of cauda epididymal sperm flagella. {ECO:0000269|PubMed:41091759}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 56..76; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 81..101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 133..153; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins