PWWP2A
entrez
114825
canonical
uniprot
Q96N64
canonical
ensembl
ENSG00000170234
resolver
ensp
ENSP00000305151
resolver
ensp
ENSP00000390462
resolver
ensp
ENSP00000428143
resolver
ensp
ENSP00000783521
resolver
genesymbol
PWWP2A
resolver
genesymbol_syn
KIAA1935
resolver
genesymbol_syn
MST101
resolver
hgnc
HGNC:29406
resolver
uniprot
G5EA07
resolver
uniprot
Q2HJJ2
resolver
uniprot
Q8IYR3
resolver
uniprot
Q96PV3
resolver
uniprot_entry
PWP2A_HUMAN
resolver
uniprot_sec
G5EA07
resolver
uniprot_sec
Q2HJJ2
resolver
uniprot_sec
Q8IYR3
resolver
uniprot_sec
Q96PV3
resolver
amino_acid_sequence
MAAVAAEAAATAASPGEGGAGEAEPEMEPIPGSEAGTDPLPVTATEASVPDGETDGQQSAPQADEPPLPPPPPPPGELARSPEAVGPELEAEEKLSVRVAESAAAAPQGGPELPPSPASPPEQPPAPEEREEPPLPQPVAPALVPPAGGDSTVSQLIPGSEVRVTLDHIIEDALVVSFRFGEKLFSGVLMDLSKRFGPHGIPVTVFPKREYKDKPEAMPLQSNTFQEGTEVKCEANGAVPDDPSPVPHPELSLAESLWTSKPPPLFHEGAPYPPPLFIRDTYNQSIPQPPPRKIKRPKRKMYREEPTSIMNAIKLRPRQVLCDKCKNSVVAEKKEIRKGSSATDSSKYEDKKRRNESVTTVNKKLKTDHKVDGKNQNESQKRNAVVKVSNIAHSRGRVVKVSAQANTSKAQLSTKKVLQSKNMDHAKAREVLKIAKEKAQKKQNETSTSKNAHSKVHFTRRYQNPSSGSLPPRVRLKPQRYRNEENDSSLKTGLEKMRSGKMAPKPQSRCTSTRSAGEAPSENQSPSKGPEEASSEVQDTNEVHVPGDQDEPQTLGKKGSKNNISVYMTLNQKKSDSSSASVCSIDSTDDLKSSNSECSSSESFDFPPGSMHAPSTSSTSSSSKEEKKLSNSLKMKVFSKNVSKCVTPDGRTICVGDIVWAKIYGFPWWPARILTITVSRKDNGLLVRQEARISWFGSPTTSFLALSQLSPFLENFQSRFNKKRKGLYRKAITEAAKAAKQLTPEVRALLTQFET
uniprot
proteins
function
FUNCTION: Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:30327463). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260, PubMed:30327463). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (By similarity). Essential for proper mitosis progression (PubMed:28645917). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:28645917, ECO:0000269|PubMed:30228260, ECO:0000269|PubMed:30327463}.
uniprot
proteins
mass_dalton
81960
uniprot
proteins
mutagenesis
MUTAGEN 666; /note="F->A: No effect on interaction with H3K36me3."; /evidence="ECO:0000269|PubMed:30327463"; MUTAGEN 669; /note="W->A: Loss of interaction with H3K36me3."; /evidence="ECO:0000269|PubMed:30327463"; MUTAGEN 695; /note="W->A: Loss of interaction with H3K36me3."; /evidence="ECO:0000269|PubMed:30327463
uniprot
proteins
pubmed
11572484
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28645917
uniprot
proteins
pubmed
30228260
uniprot
proteins
pubmed
30327463
uniprot
proteins
sequence_length
755
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28645917}.
uniprot
proteins