Tyw5
entrez
68736
canonical
uniprot
A2RSX7
canonical
ensembl
ENSMUSG00000048495
resolver
ensp
ENSMUSP00000125427
resolver
ensp
ENSMUSP00000128576
resolver
genesymbol
Tyw5
resolver
uniprot
Q3UT82
resolver
uniprot
Q4KL17
resolver
uniprot_entry
TYW5_MOUSE
resolver
uniprot_sec
Q3UT82
resolver
uniprot_sec
Q4KL17
resolver
amino_acid_sequence
MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFISKNFVYRTLPFNKLVQRAAEETHKEFFISEDEKYYLRSLGEDPRKDVADIRQQFPSLGGDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFNPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNIFWKHLPSECYDTTDTYGNKDPVAASRAVQILDRALKTLAELPEEYRDFYARQMVLRIQDKAYSKNFE
uniprot
proteins
ec_number
1.14.11.42
uniprot
proteins
function
FUNCTION: tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes. {ECO:0000250|UniProtKB:A2RUC4}.
uniprot
proteins
mass_dalton
36633
uniprot
proteins
pathway_participation
PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis. {ECO:0000250|UniProtKB:A2RUC4}.
uniprot
proteins
protein_family
TYW5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
315
uniprot
proteins