Scd2
entrez
83792
canonical
uniprot
Q6P7B9
canonical
ensembl
ENSRNOG00000046005
resolver
ensembl
ENSRNOG00055004272
resolver
ensp
ENSRNOP00000067809
resolver
ensp
ENSRNOP00055005166
resolver
enst
ENSRNOT00055006812
resolver
genesymbol
Scd2
resolver
uniprot
Q64066
resolver
uniprot
Q9JMC9
resolver
uniprot_entry
SCD2_RAT
resolver
uniprot_sec
Q64066
resolver
uniprot_sec
Q9JMC9
resolver
amino_acid_sequence
MPAHILQEISGSYSATTTITAPPSGGQQNGGEKFEKNPHHWGADVRPEIKDDLYDPSYQDEEGPPPKLEYVWRNIVLMALLHIGALYGITLVPSCKVYTCLFAYLYYVISALGITAGAHRLWSHRTYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLCVSTFLRYAVVLNATWLVNSAAHLYGYRPYDKNISSRENILVSMGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMALLGLAYDRKRVSKAAVLARIKRTGEESCKSG
uniprot
proteins
ec_number
1.14.19.1
uniprot
proteins
function
FUNCTION: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:20228221). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:20228221). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides, especially during embryonic development and in neonates. Important for normal permeability barrier function of the skin in neonates. {ECO:0000250|UniProtKB:P13011, ECO:0000269|PubMed:20228221}.
uniprot
proteins
mass_dalton
41013
uniprot
proteins
protein_family
Fatty acid desaturase type 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1982442
uniprot
proteins
pubmed
20228221
uniprot
proteins
pubmed
7800118
uniprot
proteins
sequence_length
358
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P13011}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P13011}. Microsome membrane {ECO:0000250|UniProtKB:P13011}.
uniprot
proteins
transmembrane_region
TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O00767"; TRANSMEM 97..117; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O00767"; TRANSMEM 217..236; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O00767"; TRANSMEM 241..262; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O00767
uniprot
proteins