C2cd3
entrez
277939
canonical
uniprot
Q52KB6
canonical
ensembl
ENSMUSG00000047248
resolver
ensp
ENSMUSP00000062637
resolver
ensp
ENSMUSP00000095859
resolver
genesymbol
C2cd3
resolver
genesymbol_syn
Hty
resolver
uniprot
E9QL99
resolver
uniprot
Q3UFQ3
resolver
uniprot
Q80V48
resolver
uniprot
Q8BXE5
resolver
uniprot_entry
C2CD3_MOUSE
resolver
uniprot_sec
E9QL99
resolver
uniprot_sec
Q3UFQ3
resolver
uniprot_sec
Q80V48
resolver
uniprot_sec
Q8BXE5
resolver
amino_acid_sequence
MKQRKGQGPGGGRGRKKRGLSDISPSTSLPPLVEGQLRCFLKLTINKVVWKIAKPPTSVLVRVRWWGETSDGTLFCPRDALQTEPKAVRTTTRYGIRCGPKQFTSYLTDMAVLVLEVITKFDHLPVGRVQISGLAQLSPTHQINGFFTIVSPASKKLGELQVSLALEPLSETYDSYKPLPATEVTKNVLLSERELRENTESSNTQSMIPSRSCRGPAIKIDGKELAGHSSRSTTPRGKDHLYFAENSDAVKGSLCGLQQHLNQGTNVETITLRGKAPQKQLSLLNSSEFQPQISTVAKSHSDSCILSSNTPPAKDLLSALLEQGNKLRNAMLISAMNSNPDTSMLLDKVPPPMTEAIPRSSALNSSENHFKGHSADHLLPLADTGAIQLLLGSAELSQGHFWNGLGSPPDSPTPGSDEYCSSDLNDPQYDQSLLENLFYTVPKSDVGTSELPSEDDGVEPSRTMNQSKASGRSKVVESKEQKQKRAAVKKSRNPIDQQELSRTPGHTPAMSLSVDRLALLGRVHSVRIIVETMGVPPDSPHMTPSRKNFAGKPPKPTAAKKRTFFVEYHFPVGFSKSGLGKTALITEVVRLASSKITDGVVKFQQRFVCPVEFGGPMIEHWWDSNLIFQIYAKKTPQKKPEVIGSASLPLRAVIQSELLSFSSQLPVQQENGLSSLGPLKVTMELVLGHKDFTGISAKLSSSTQPAPVSAATSSDTILPETGQDTACTRNPQSSNKIHEETTKKTQNLVLPDQESANSVASNSSIFMAVPSCNLVHQINGSNKESGLLLHVLLMVPDGKDFVFGEREKQPSCNVYLNCKLFSTEEVTRSVVSWGTAQPVFNFSQVIPVSLTSKCLERLKNNVMIIETWNKVRSPGQDKLLGLVKLPLHQFYMSFKDPKISRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSAQIMMLQRLKNEEGTLPPFSPRPAHFLDQPPVASVAMPEKQGTRLMEHHFEFCVAMVKGLMPLQATVWGEADCYVQYYFPFQDSQPSVLQGPDFLENGITLKPFRTSTTLCVPDPVFNSEHHHSLLLPTDVPVQRLLLSAFSSQGLVPGGGVQFEVWCRYYYPNVRDQMVAKGTLPLSRVCAMVTMQYREDVGMQSFNLPLTSRLEHSKELKNQSSGFLDVGLRYRRSPRTAEGILAARAVSISVHIIRACGLQAAAKALAEQEPALQFSATVGVNASVTAHLSFLPKGEQRQTRPVACSFCPEFSHHIEFPCNLVTQHCSGEACFLAELLEFAEIIFAIYHENTKSVSDITSIQSCKDYLLGIVKVPTKDLLVKRSGITGWYPVILPEDKGLPQDLDLMQKIVGGLELSVSFAHPGDRERVLEAAELLGWSFESIPKDLVKKEEEVPATVTISTPRLWLPIHCVLLAGHMNIHKNTYCYLRYKLYNQEAFWTPLRKPKESTNKNQVLITFKASKRAEVTRSQSLLWYFREEKLEIQVWRAYGNDNLERPHQTDSWIGSAYVDLSRLGEKSPRTLTISGVYPLFGRNASDLSGAALRIHVLLSPLSPHTEPARELDSMDCSSHSESEQHPRKSDALQLSPPHVLQTSPTSTQVHGNSAAAQVCPAQEGPPELAGTFAVSILVERAMHLSLKGSPLTDRKVSVPSCCVSFATATELSPVYTHVVENTDSPIWGFHQQARLSKELLLDPHQTLVFKVWHKGDEERVVGFASVDLSPLLSGFQFICGWYNITDFSGECQGQIKVAISPMESLMHLKEERQARRGIDTPGALIPLFSALSFPASAGCDAFPRPIARHVEGQLAHTSPKEDGLSSPARNGAIRSQAARHEEHVQNIRRFHESLQHGEAVLTSDEKLTTAPSSSHTSILTSLRKNLSELDEIQKYFSQKLSKPFLPFSSQSSPAVSQSQESQRDPVAAGTGRQDPENQCILEKSNHLVSQVSSLISDLQTLTRGSQAALTSQQARSRSRAVTTIPDAQGTEAAGEGSTTLEEPLAGAIEASTDSLPPPVEEPSKGGGMLHESLEQTMPITRVQSIDDTEVGPDYSDEDYEEDIIEPRTLNEITTVTDRTSPWSSFMSDMSEVLSPQPTEVQREGPSCPPEPFPREELKVKSSPQKAVSPQPAQGSPSQSGVCEGGAYKIEVEDLASAKPQPVPSLTFSEAQEGSDSVGWRASQINQVRKPMPEMLAESEAFSSEFSDSSESFETFPLHLPSQSKREDYKDSPAVRQKQVPTGSEVSTRQTLLLPEPVVVPNFFLPPQQLEASLRMISHSPGLPPAATTDQDKSEATRGALAQRPCRPRPYSIPPNLPEEETRRIARIFSSQYSKKTEET
uniprot
proteins
function
FUNCTION: Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation (PubMed:24469809). Required for primary cilium formation. Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3 (PubMed:19004860). {ECO:0000269|PubMed:19004860, ECO:0000269|PubMed:24469809, ECO:0000269|PubMed:24997988}.
uniprot
proteins
mass_dalton
255346
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19004860
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24469809
uniprot
proteins
pubmed
24997988
uniprot
proteins
sequence_length
2323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to centrioles and procentrioles both in interphase and mitosis. Localizes to centriolar satellites, localization is dependent on PCM1 and dynein-mediated retrograde transport. Also localizes to the distal ends of the mother and daughter centrioles (PubMed:24469809). {ECO:0000269|PubMed:24469809}.
uniprot
proteins