Trim40
entrez
365528
canonical
uniprot
Q6MFY8
canonical
ensembl
ENSRNOG00000000783
resolver
ensembl
ENSRNOG00065028603
resolver
ensp
ENSRNOP00000098139
resolver
ensp
ENSRNOP00065040439
resolver
enst
ENSRNOT00000120475
resolver
enst
ENSRNOT00065049306
resolver
genesymbol
Trim40
resolver
genesymbol_syn
Rnf35
resolver
uniprot_entry
TRI40_RAT
resolver
amino_acid_sequence
MVPLDKDNQDICPICLDPLKEAVSTDCRHLFCRMCLIRHMDKASVSGVLSCPVCRKPCSETVLGDNYICHTHQKRVCRFCESSRHLLCEECLQSPEHRAHTELSIENAISHYKERLNRRSRKLRKDLGDLQRLKAQEEKMLQALQVDWGSHRPRTEQQNQDQTELQQKALPRHWLDQREDPPEEVAKVFNFSEAVTQLSILVSSLERMAKELDASTLKDASDLLDRSSQQKLEGLLSHVPPANSKLS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response. Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation. Also promotes the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation. {ECO:0000250|UniProtKB:Q6P9F5}.
uniprot
proteins
mass_dalton
28389
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
15060004
uniprot
proteins
sequence_length
247
uniprot
proteins