H1-10
entrez
8971
canonical
uniprot
Q92522
canonical
ensembl
ENSG00000184897
resolver
ensp
ENSP00000329662
resolver
enst
ENST00000333762
resolver
genesymbol
H1-10
resolver
genesymbol_syn
H1FX
resolver
hgnc
HGNC:4722
resolver
uniprot_entry
H1X_HUMAN
resolver
amino_acid_sequence
MSVELEEALPVTTAEGMAKKVTKAGGSAALSPSKKRKNSKKKNQPGKYSQLVVETIRRLGERNGSSLAKIYTEAKKVPWFDQQNGRTYLKYSIKALVQNDTLLQVKGTGANGSFKLNRKKLEGGGERRGAPAAATAPAPTAHKAKKAAPGAAGSRRADKKPARGQKPEQRSHKKGAGAKKDKGGKAKKTAAAGGKKVKKAAKPSVPKVPKGRK
uniprot
proteins
function
FUNCTION: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:33238161). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed:33238161, PubMed:40516528). {ECO:0000269|PubMed:33238161, ECO:0000269|PubMed:40516528}.
uniprot
proteins
mass_dalton
22487
uniprot
proteins
post_translational_modification
PTM: Citrullination at Arg-62 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. {ECO:0000250|UniProtKB:P43275}.
uniprot
proteins
protein_family
Histone H1/H5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19710015
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25645921
uniprot
proteins
pubmed
33238161
uniprot
proteins
pubmed
38530350
uniprot
proteins
pubmed
40516528
uniprot
proteins
pubmed
40516529
uniprot
proteins
pubmed
8964515
uniprot
proteins
sequence_length
213
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:25645921, ECO:0000269|PubMed:38530350}. Nucleus, nucleolus {ECO:0000269|PubMed:38530350}. Chromosome {ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:25645921, ECO:0000269|PubMed:38530350}. Note=Associated with RNA polymerase II-enriched regions on chromatin (PubMed:25645921). Distributed throughout the nucleus; enriched in high-GC regions (PubMed:38530350). {ECO:0000269|PubMed:25645921, ECO:0000269|PubMed:38530350}.
uniprot
proteins