Grm1
entrez
14816
canonical
uniprot
P97772
canonical
ensembl
ENSMUSG00000019828
resolver
ensp
ENSMUSP00000037255
resolver
ensp
ENSMUSP00000101189
resolver
ensp
ENSMUSP00000101190
resolver
ensp
ENSMUSP00000255463
resolver
ensp
ENSMUSP00000255467
resolver
genesymbol
Grm1
resolver
genesymbol_syn
Gprc1a
resolver
genesymbol_syn
Mglur1
resolver
uniprot
Q3V0U2
resolver
uniprot
Q6AXG4
resolver
uniprot
Q9EPV6
resolver
uniprot_entry
GRM1_MOUSE
resolver
uniprot_entry
Q3V0U2_MOUSE
resolver
uniprot_sec
Q6AXG4
resolver
uniprot_sec
Q9EPV6
resolver
amino_acid_sequence
MVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGYVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPITIRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVWQRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSTHFSPPSSPSMVVHRRGPPVATTPPLPPHLSAEETPLFLADSVIPKGLPPPLPQQQQQPPPQPPPQQPKSLMDQLQGVVTNFGSGIPDFHAVLAGPGTPGNGLRSLYPPPPPPQHLQMLPLQLSTFREEPISPPGEDDDDDSSERFKLLQEFVYEREGNTEEDDLEEEEDLPAASKLTPEDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILRDYKQSSSTL
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity). May function in the light response in the retina (PubMed:26427409). Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell, respectively (PubMed:24357660, PubMed:27276689, PubMed:28696429). {ECO:0000269|PubMed:24357660, ECO:0000269|PubMed:26427409, ECO:0000269|PubMed:27276689, ECO:0000269|PubMed:28696429}.
uniprot
proteins
mass_dalton
133212
uniprot
proteins
mutagenesis
MUTAGEN 536; /note="I->K: Normal response to light but reduced retinal electrical activity in response to light in dark adapted retinas. Gross morphology is normal."; /evidence="ECO:0000269|PubMed:26427409
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
pubmed
10581402
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17296554
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24357660
uniprot
proteins
pubmed
26427409
uniprot
proteins
pubmed
27276689
uniprot
proteins
pubmed
28696429
uniprot
proteins
pubmed
33488348
uniprot
proteins
sequence_length
1199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13255}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13255}. Postsynaptic cell membrane {ECO:0000269|PubMed:27276689}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:33488348}. Note=Located in dendrioles, small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell. {ECO:0000269|PubMed:33488348}.
uniprot
proteins
transmembrane_region
TRANSMEM 593..615; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 630..650; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 659..680; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 704..727; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 751..772; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 786..807; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 816..840; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins