Dab1
entrez
266729
canonical
uniprot
Q8CJH2
canonical
ensembl
ENSRNOG00000007410
resolver
ensembl
ENSRNOG00055007126
resolver
ensembl
ENSRNOG00060018596
resolver
ensembl
ENSRNOG00065022215
resolver
ensp
ENSRNOP00000009977
resolver
ensp
ENSRNOP00000071602
resolver
ensp
ENSRNOP00000077479
resolver
ensp
ENSRNOP00000089729
resolver
ensp
ENSRNOP00000098304
resolver
ensp
ENSRNOP00055009351
resolver
ensp
ENSRNOP00060026111
resolver
ensp
ENSRNOP00065030660
resolver
enst
ENSRNOT00000009977
resolver
enst
ENSRNOT00000082021
resolver
enst
ENSRNOT00000094730
resolver
enst
ENSRNOT00000111283
resolver
enst
ENSRNOT00000120672
resolver
enst
ENSRNOT00055011840
resolver
enst
ENSRNOT00060032094
resolver
enst
ENSRNOT00065037902
resolver
genesymbol
Dab1
resolver
uniprot
A0A0G2K0W1
resolver
uniprot
A0A8I5YBU9
resolver
uniprot
A0A8I6AAY7
resolver
uniprot
A0ABK0L5B7
resolver
uniprot_entry
A0A0G2K0W1_RAT
resolver
uniprot_entry
A0A8I5YBU9_RAT
resolver
uniprot_entry
A0A8I6AAY7_RAT
resolver
uniprot_entry
A0ABK0L5B7_RAT
resolver
uniprot_entry
DAB1_RAT
resolver
amino_acid_sequence
MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPVSAVTQLELFGDMSTPPDITSPPTPATPGDAFLPAPSQTLPGSADVFGSMSFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQIAMGAQPPVAQVIPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTNDSARSSPQSDKPRQKMGKEMFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHVSDPTADDIFEEGFESPSKSEEQEAPDGSQASSTSDPFGEPSGEPSGDNISPQDGS
uniprot
proteins
function
FUNCTION: Signaling adapter of the reelin-mediated signaling pathway, which regulates the migration and differentiation of postmitotic neurons during brain development. Mediates intracellular transduction of Reelin signaling following reelin (RELN)-binding to its receptor: acts by docking proteins through its phosphotyrosine residues and PID domain. {ECO:0000250|UniProtKB:P97318}.
uniprot
proteins
mass_dalton
59900
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FYN on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-491 independently of reelin signaling. {ECO:0000250|UniProtKB:P97318}.; PTM: Ubiquitinated by various cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes) following ligand-binding and phosphorylation, leading to its degradation. Ubiquitinated by the ECS(SOCS7) complex in the cortical plate of the developing cerebral cortex following ligand-binding and phosphorylation by FYN, leading to its degradation by the proteasome. Recognized by ZSWIM8 through a disorder targets misorder mechanism that eliminates misfolded DAB1 via ubiquitination and proteasomal degradation. {ECO:0000250|UniProtKB:O75553, ECO:0000250|UniProtKB:P97318}.
uniprot
proteins
pubmed
11812785
uniprot
proteins
pubmed
16641100
uniprot
proteins
sequence_length
555
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P97318}.
uniprot
proteins