Nrgn
entrez
64011
canonical
uniprot
P60761
canonical
ensembl
ENSMUSG00000053310
resolver
ensp
ENSMUSP00000070113
resolver
enst
ENSMUST00000065668
resolver
genesymbol
Nrgn
resolver
uniprot
B2RRN7
resolver
uniprot
Q3TYH4
resolver
uniprot_entry
NEUG_MOUSE
resolver
uniprot_sec
B2RRN7
resolver
uniprot_sec
Q3TYH4
resolver
amino_acid_sequence
MDCCTESACSKPDDDILDIPLDDPGANAAAAKIQASFRGHMARKKIKSGECGRKGPGPGGPGGAGGARGGAGGGPSGD
uniprot
proteins
function
FUNCTION: Regulates the affinity of calmodulin for calcium. Involved in synaptic plasticity and spatial learning. {ECO:0000269|PubMed:11016969}.
uniprot
proteins
mass_dalton
7496
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="R->A: Abolishes calmodulin binding, unable to potentiate synaptic transmission."; /evidence="ECO:0000269|PubMed:23462742
uniprot
proteins
post_translational_modification
PTM: Disulfide bond formation is redox-sensitive. The cysteine residues are readily oxidized by several nitric acid (NO) donors and other oxidants to form intramolecular disulfide. Cys-51 can form a disulfide with any other of the cysteine residues with an order of reactivity Cys-9 > Cys-4 > Cys-3 (By similarity). {ECO:0000250}.; PTM: Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions. {ECO:0000269|PubMed:23462742}.
uniprot
proteins
protein_family
Neurogranin family
uniprot
proteins
pubmed
11016969
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23462742
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
78
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Synapse. Cell projection, dendritic spine. Note=Restricted to dendritic spines of a subset of neurons. {ECO:0000250}.
uniprot
proteins