TPH1
entrez
7166
canonical
uniprot
P17752
canonical
ensembl
ENSG00000129167
resolver
ensp
ENSP00000508368
resolver
genesymbol
TPH1
resolver
genesymbol_syn
TPH
resolver
genesymbol_syn
TPRH
resolver
genesymbol_syn
TRPH
resolver
hgnc
HGNC:12008
resolver
uniprot
D3DQX6
resolver
uniprot
O95188
resolver
uniprot
O95189
resolver
uniprot
Q16736
resolver
uniprot
Q3KPG8
resolver
uniprot_entry
TPH1_HUMAN
resolver
uniprot_sec
D3DQX6
resolver
uniprot_sec
O95188
resolver
uniprot_sec
O95189
resolver
uniprot_sec
Q16736
resolver
uniprot_sec
Q3KPG8
resolver
amino_acid_sequence
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
uniprot
proteins
ec_number
1.14.16.4
uniprot
proteins
function
FUNCTION: Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis. {ECO:0000250|UniProtKB:P17532}.
uniprot
proteins
mass_dalton
50985
uniprot
proteins
pathway_participation
PATHWAY: Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2. {ECO:0000250|UniProtKB:P17532}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation by the proteasome. Ubiquitinated is triggered by phosphorylation. {ECO:0000250|UniProtKB:P09810}.; PTM: Phosphorylated; triggering degradation by the proteasome. {ECO:0000250|UniProtKB:P09810}.
uniprot
proteins
protein_family
Biopterin-dependent aromatic amino acid hydroxylase family
uniprot
proteins
pubmed
12379098
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2377472
uniprot
proteins
pubmed
7986090
uniprot
proteins
pubmed
9751214
uniprot
proteins
sequence_length
444
uniprot
proteins