Slc17a8
entrez
266767
canonical
uniprot
Q7TSF2
canonical
ensembl
ENSRNOG00000007581
resolver
ensembl
ENSRNOG00055020290
resolver
ensembl
ENSRNOG00060022095
resolver
ensembl
ENSRNOG00065022388
resolver
ensp
ENSRNOP00000075876
resolver
ensp
ENSRNOP00000102402
resolver
ensp
ENSRNOP00055028079
resolver
ensp
ENSRNOP00060031580
resolver
ensp
ENSRNOP00065030920
resolver
enst
ENSRNOT00000092527
resolver
enst
ENSRNOT00000146419
resolver
enst
ENSRNOT00055034654
resolver
enst
ENSRNOT00060038306
resolver
enst
ENSRNOT00065038191
resolver
genesymbol
Slc17a8
resolver
genesymbol_syn
Vglut3
resolver
uniprot
A0ABK0LAV5
resolver
uniprot
Q8K1Q1
resolver
uniprot_entry
A0ABK0LAV5_RAT
resolver
uniprot_entry
VGLU3_RAT
resolver
uniprot_sec
Q8K1Q1
resolver
activity_regulation
ACTIVITY REGULATION: The L-glutamate uniporter activity exhibits a biphasic dependence on chloride concentration (PubMed:12388773). Chloride channel activity is allosterically activated by lumenal H(+) and Cl(-) leading to synaptic vesicles acidification (PubMed:27133463). The glutamate transport activity is allosterically activated by lumenal H(+) and Cl(-), preventing non-vesicular L-glutamate release (PubMed:27133463). {ECO:0000269|PubMed:12388773, ECO:0000269|PubMed:27133463}.
uniprot
proteins
amino_acid_sequence
MPFNAFDTFKEKILKPGKEGVKNAVGDSLGILQRKLDGTNEEGDAIELSEEGRPVQTSRARAPVCDCSCCGIPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLLQAYECPAVHPTISNEERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQDWADPENLSEEKCGIIDQDELAEETELNHEAFVSPRKKMSYGATTQNCEVQKTDRRQQRESAFEGEEPLSYQNEEDFSETS
uniprot
proteins
function
FUNCTION: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, sodium and phosphate (PubMed:12097496, PubMed:12388773, PubMed:27133463). At the synaptic vesicle membrane, mainly functions as an uniporter that mediates the uptake of L-glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:12097496, PubMed:12388773, PubMed:27133463). The L-glutamate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:12097496, PubMed:12388773). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (PubMed:27133463). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (By similarity). The symporter activity is electrogenic (By similarity). Moreover, operates synergistically with SLC18A3/VACHT under a constant H(+) gradient, thereby allowing striatal vesicular acetylcholine uptake (PubMed:18278042). {ECO:0000250|UniProtKB:Q8NDX2, ECO:0000269|PubMed:12097496, ECO:0000269|PubMed:12388773, ECO:0000269|PubMed:18278042, ECO:0000269|PubMed:27133463}.
uniprot
proteins
mass_dalton
64755
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sodium/anion cotransporter family
uniprot
proteins
protein_family
VGLUT subfamily
uniprot
proteins
pubmed
12097496
uniprot
proteins
pubmed
12384506
uniprot
proteins
pubmed
12388773
uniprot
proteins
pubmed
14751290
uniprot
proteins
pubmed
15746915
uniprot
proteins
pubmed
17110340
uniprot
proteins
pubmed
18215623
uniprot
proteins
pubmed
18278042
uniprot
proteins
pubmed
27133463
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:12384506, ECO:0000269|PubMed:12388773, ECO:0000305|PubMed:12097496}. Cell membrane {ECO:0000250|UniProtKB:Q8NDX2}; Multi-pass membrane protein {ECO:0000305}. Synapse, synaptosome {ECO:0000269|PubMed:12384506, ECO:0000269|PubMed:12388773}.
uniprot
proteins
transmembrane_region
TRANSMEM 77..97; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 131..151; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 154..174; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 222..242; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 250..270; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 315..335; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 354..374; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 391..411; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 414..434; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 448..468; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 482..502; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins