RAB37
entrez
326624
canonical
uniprot
Q96AX2
canonical
ensembl
ENSG00000172794
resolver
ensp
ENSP00000376388
resolver
ensp
ENSP00000376389
resolver
ensp
ENSP00000376390
resolver
ensp
ENSP00000383934
resolver
ensp
ENSP00000432086
resolver
enst
ENST00000392614
resolver
enst
ENST00000528438
resolver
genesymbol
RAB37
resolver
hgnc
HGNC:30268
resolver
uniprot
A0A9H3ZVF6
resolver
uniprot
A8MXF5
resolver
uniprot
A8MYT0
resolver
uniprot
B3KPZ5
resolver
uniprot
B7Z3L0
resolver
uniprot
F6QQS2
resolver
uniprot
Q8IWA7
resolver
uniprot_entry
A0A9H3ZVF6_HUMAN
resolver
uniprot_entry
B3KPZ5_HUMAN
resolver
uniprot_entry
B7Z3L0_HUMAN
resolver
uniprot_entry
F6QQS2_HUMAN
resolver
uniprot_entry
RAB37_HUMAN
resolver
uniprot_sec
A8MXF5
resolver
uniprot_sec
A8MYT0
resolver
uniprot_sec
Q8IWA7
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including RPGR which promote the exchange of bound GDP for free GTP (PubMed:38536817). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000269|PubMed:38536817, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MTGTPGAVATRDGEAPERSPPCSPSYDLTGKVMLLGDTGVGKTCFLIQFKDGAFLSGTFIATVGIDFRNKVVTVDGVRVKLQIWDTAGQERFRSVTHAYYRDAQALLLLYDITNKSSFDNIRAWLTEIHEYAQRDVVIMLLGNKADMSSERVIRSEDGETLAREYGVPFLETSAKTGMNVELAFLAIAKELKYRAGHQADEPSFQIRDYVESQKKRSSCCSFM
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:38536817). Acts as an organizer for autophagosome biogenesis in a GTP-dependent manner (PubMed:38536817). Involved in retinal homeostasis by autophagy regulation (PubMed:38536817). {ECO:0000269|PubMed:38536817}.
uniprot
proteins
mass_dalton
24815
uniprot
proteins
mutagenesis
MUTAGEN 43; /note="T->N: Stimulates interaction with RPGR. Loss of exchange between RAB37-GDP to RAB37-GTP."; /evidence="ECO:0000269|PubMed:38536817"; MUTAGEN 89; /note="Q->L: Decreased interaction with RPGR. Loss of exchange between RAB37-GDP to RAB37-GTP."; /evidence="ECO:0000269|PubMed:38536817
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
38536817
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9JKM7}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9JKM7}. Note=Secretory granules. Located mainly in the connecting cilia between the outer segment and inner segment and also observed in the outer plexiform layer, inner plexiform layer, and ganglion cell layer of the retinas. {ECO:0000250|UniProtKB:Q9JKM7}.
uniprot
proteins