Pank2
entrez
74450
canonical
uniprot
Q7M753
canonical
ensembl
ENSMUSG00000037514
resolver
ensp
ENSMUSP00000119606
resolver
enst
ENSMUST00000150843
resolver
genesymbol
Pank2
resolver
uniprot
Q3U4S0
resolver
uniprot_entry
PANK2_MOUSE
resolver
uniprot_sec
Q3U4S0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by acetyl-CoA (PubMed:17825826). Inhibited by calcium hopantenate (PubMed:17379144). Activated by palmitoylcarnitine (PubMed:17825826). {ECO:0000269|PubMed:17379144, ECO:0000269|PubMed:17825826}.
uniprot
proteins
amino_acid_sequence
MGGWLGRQRRLLRMGAGRFGAPMERQGRAAATSAAVGESADSEARRRDPLRRRASSAAPSGSGEAESVRRERPGSLGGSTSAGRPRAEGLRKRRPLFPWFGLDIGGTLVKLVYFEPKDITAEEEKEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIRFPTHDMPAFIQMGRDKNFSSLHTVFCATGGGSYKFEQDFLTIGDLQLRKLDELDCLIKGILYIDSVGFNGRSQCYYFENPADSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYKRVTGTSLGGGTFFGLCCLLTGCSTFEEALEMASRGDSTKVDKLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKREAASKEDLARATLITITNNIGSIARMCALNENINQVVFVGNFLRVNTIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALLELLKIP
uniprot
proteins
ec_number
2.7.1.33
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269|PubMed:17379144, ECO:0000269|PubMed:17825826, ECO:0000269|PubMed:22815849}.
uniprot
proteins
mass_dalton
50212
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. {ECO:0000269|PubMed:17379144, ECO:0000269|PubMed:17825826, ECO:0000269|PubMed:22815849}.
uniprot
proteins
protein_family
Type II pantothenate kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17379144
uniprot
proteins
pubmed
17825826
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22815849
uniprot
proteins
pubmed
23152917
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17825826, ECO:0000269|PubMed:23152917}.
uniprot
proteins