Map3k3
entrez
26406
canonical
uniprot
Q61084
canonical
ensembl
ENSMUSG00000020700
resolver
ensp
ENSMUSP00000002044
resolver
ensp
ENSMUSP00000312971
resolver
enst
ENSMUST00000002044
resolver
genesymbol
Map3k3
resolver
genesymbol_syn
Mekk3
resolver
uniprot_entry
M3K3_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-530. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MDEQEALDSIMKDLVALQMSRRTRLSGYETMKNKDTGHPNRQSDVRIKFEHNGERRIIAFSRPVRYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHTSSSPHSGVSRQVRIKPSQSAGDINTIYQAPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSQMSRARSFPDNRKECSDRETQLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGVAVQYLDPRGRLRSADSENALTVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLVY
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:8621389}.
uniprot
proteins
mass_dalton
70776
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-166 and Ser-337 by SGK1 inhibits its activity. {ECO:0000250}.
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
12391307
uniprot
proteins
pubmed
14634666
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8621389
uniprot
proteins
sequence_length
626
uniprot
proteins