Kcne2
entrez
246133
canonical
uniprot
Q9D808
canonical
ensembl
ENSMUSG00000039672
resolver
ensp
ENSMUSP00000048849
resolver
ensp
ENSMUSP00000109604
resolver
enst
ENSMUST00000047383
resolver
enst
ENSMUST00000113971
resolver
genesymbol
Kcne2
resolver
uniprot
A0A0R4J1J2
resolver
uniprot
Q8R1Z7
resolver
uniprot_entry
A0A0R4J1J2_MOUSE
resolver
uniprot_entry
KCNE2_MOUSE
resolver
uniprot_sec
Q8R1Z7
resolver
amino_acid_sequence
MATLANLTQTLEDAFKKIFITYMDSWRRNTTAEEQALQARVDAENFYYVILYLMVMIGMFSFIVVAILVSTVKSKRREHSQHPYHQYIVEDWQEKYKSQILHLEDSKATIHENMGATGFTVSP
uniprot
proteins
function
FUNCTION: Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE2 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:24595108). Associates with KCNH2/HERG alpha subunit Kv channel to form the rapidly activating component of the delayed rectifying potassium current (IKr) in heart. May associate with KCNQ2 and/or KCNQ3 alpha subunits to modulate the native M-type current (By similarity). May associate with HCN1 and HCN2 channel subunits to increase potassium current (By similarity). Forms a heterooligomer complex with KCNQ1/KVLQT1 alpha subunits which leads to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (PubMed:24595108). {ECO:0000250|UniProtKB:P63161, ECO:0000250|UniProtKB:Q9Y6J6, ECO:0000269|PubMed:24595108}.
uniprot
proteins
mass_dalton
14370
uniprot
proteins
protein_family
Potassium channel KCNE family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24595108
uniprot
proteins
sequence_length
123
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P63161, ECO:0000250|UniProtKB:Q9Y6J6}; Single-pass type I membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:24595108}; Single-pass membrane protein {ECO:0000255}. Note=Colocalizes with KCNB1 at the plasma membrane. Localizes at the apical membrane of the choroid plexus epithelium. {ECO:0000250|UniProtKB:P63161, ECO:0000269|PubMed:24595108}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins