Snf8
entrez
287645
canonical
uniprot
Q5RK19
canonical
ensembl
ENSRNOG00000006500
resolver
ensembl
ENSRNOG00065017962
resolver
ensp
ENSRNOP00000008964
resolver
ensp
ENSRNOP00000087170
resolver
ensp
ENSRNOP00065023940
resolver
enst
ENSRNOT00000008964
resolver
enst
ENSRNOT00000110029
resolver
enst
ENSRNOT00065030121
resolver
genesymbol
Snf8
resolver
genesymbol_syn
Eap30
resolver
uniprot
A0A8I6A7G8
resolver
uniprot_entry
A0A8I6A7G8_RAT
resolver
uniprot_entry
SNF8_RAT
resolver
amino_acid_sequence
MHRRGVGAGAIAKKKLAEAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFTDLYSQEISAEEAKEVFP
uniprot
proteins
function
FUNCTION: Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs, and plays a role in autophagy. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). {ECO:0000250|UniProtKB:Q5U3V9, ECO:0000250|UniProtKB:Q96H20, ECO:0000269|PubMed:10419521}.
uniprot
proteins
mass_dalton
28884
uniprot
proteins
protein_family
SNF8 family
uniprot
proteins
pubmed
10419521
uniprot
proteins
pubmed
11278625
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
258
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane {ECO:0000250}. Nucleus {ECO:0000305}. Late endosome membrane {ECO:0000250}. Note=Recruited to the endosome membrane to participate in vesicle formation. {ECO:0000250}.
uniprot
proteins