HIF3A
entrez
64344
canonical
uniprot
Q9Y2N7
canonical
ensembl
ENSG00000124440
resolver
ensp
ENSP00000244303
resolver
ensp
ENSP00000300862
resolver
ensp
ENSP00000366898
resolver
ensp
ENSP00000434653
resolver
ensp
ENSP00000471560
resolver
ensp
ENSP00000674384
resolver
ensp
ENSP00000674385
resolver
ensp
ENSP00000712625
resolver
ensp
ENSP00000712627
resolver
ensp
ENSP00000712628
resolver
ensp
ENSP00000712629
resolver
ensp
ENSP00000737210
resolver
ensp
ENSP00000737211
resolver
enst
ENST00000472815
resolver
enst
ENST00000600383
resolver
genesymbol
HIF3A
resolver
genesymbol_syn
BHLHE17
resolver
genesymbol_syn
MOP7
resolver
genesymbol_syn
PASD7
resolver
hgnc
HGNC:15825
resolver
uniprot
B0M185
resolver
uniprot
B2RBI6
resolver
uniprot
B4DNA2
resolver
uniprot
H0YDZ5
resolver
uniprot
I6L988
resolver
uniprot
M0R104
resolver
uniprot
Q58A43
resolver
uniprot
Q66K72
resolver
uniprot
Q8WXA1
resolver
uniprot
Q96K34
resolver
uniprot
Q9H7Z9
resolver
uniprot
Q9HAI2
resolver
uniprot_entry
B2RBI6_HUMAN
resolver
uniprot_entry
H0YDZ5_HUMAN
resolver
uniprot_entry
HIF3A_HUMAN
resolver
uniprot_entry
M0R104_HUMAN
resolver
uniprot_sec
B0M185
resolver
uniprot_sec
B4DNA2
resolver
uniprot_sec
I6L988
resolver
uniprot_sec
Q58A43
resolver
uniprot_sec
Q66K72
resolver
uniprot_sec
Q8WXA1
resolver
uniprot_sec
Q96K34
resolver
uniprot_sec
Q9H7Z9
resolver
uniprot_sec
Q9HAI2
resolver
amino_acid_sequence
MALGLQRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQPRAGSAQAD
uniprot
proteins
function
FUNCTION: Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422). Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity). {ECO:0000250|UniProtKB:Q0VBL6, ECO:0000269|PubMed:11573933, ECO:0000269|PubMed:16126907, ECO:0000269|PubMed:19694616, ECO:0000269|PubMed:20416395, ECO:0000269|PubMed:21069422}.; FUNCTION: [Isoform 2]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Also inhibits hypoxia-inducible ARNT-mediated gene expression. {ECO:0000269|PubMed:11573933}.; FUNCTION: [Isoform 3]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. {ECO:0000269|PubMed:19694616, ECO:0000269|PubMed:20416395, ECO:0000269|PubMed:21069422}.; FUNCTION: [Isoform 4]: Attenuates the ability of transcription factor HIF1A and EPAS1/HIF2A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:16126907, PubMed:17998805, PubMed:19694616, PubMed:20416395). May act as a tumor suppressor and inhibits malignant cell transformation (PubMed:17998805). {ECO:0000269|PubMed:16126907, ECO:0000269|PubMed:17998805, ECO:0000269|PubMed:19694616, ECO:0000269|PubMed:20416395}.; FUNCTION: [Isoform 5]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. {ECO:0000269|PubMed:21069422}.
uniprot
proteins
mass_dalton
72433
uniprot
proteins
mutagenesis
MUTAGEN 467; /note="K->R: No loss of ubiquitination. Reduced ubiquitination; when associated with R-570."; /evidence="ECO:0000269|PubMed:12538644"; MUTAGEN 492; /note="P->A: Reduced hydroxylation activity. Reduced ubiquitination."; /evidence="ECO:0000269|PubMed:12538644"; MUTAGEN 570; /note="K->R: No loss of ubiquitination. Reduced ubiquitination; when associated with R-467."; /evidence="ECO:0000269|PubMed:12538644
uniprot
proteins
post_translational_modification
PTM: In normoxia, hydroxylated on Pro-492 in the oxygen-dependent degradation domain (ODD) by prolyl hydroxylase(s) (PHD). The hydroxylated proline promotes interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. {ECO:0000269|PubMed:12538644}.; PTM: Ubiquitinated; ubiquitination occurs in a VHL- and oxygen-dependent pathway and subsequently targeted for proteasomal degradation. {ECO:0000269|PubMed:12538644}.
uniprot
proteins
pubmed
11573933
uniprot
proteins
pubmed
12538644
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16126907
uniprot
proteins
pubmed
16775626
uniprot
proteins
pubmed
17998805
uniprot
proteins
pubmed
19694616
uniprot
proteins
pubmed
20416395
uniprot
proteins
pubmed
21069422
uniprot
proteins
sequence_length
669
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16775626, ECO:0000269|PubMed:19694616}. Cytoplasm {ECO:0000269|PubMed:19694616}. Nucleus speckle {ECO:0000250|UniProtKB:Q0VBL6}. Mitochondrion {ECO:0000250|UniProtKB:Q0VBL6}. Note=In the nuclei of all periportal and perivenous hepatocytes. In the distal perivenous zone, detected in the cytoplasm of the hepatocytes. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes with BAD in the cytoplasm. Colocalizes with EPAS1 and HIF1A in the nucleus and speckles (By similarity). Localized in the cytoplasm and nuclei under normoxia, but increased in the nucleus under hypoxic conditions (PubMed:19694616). Colocalized with HIF1A in kidney tumors (PubMed:19694616). {ECO:0000250|UniProtKB:Q0VBL6, ECO:0000250|UniProtKB:Q9JHS2, ECO:0000269|PubMed:19694616}.
uniprot
proteins