HCRT
entrez
3060
canonical
uniprot
O43612
canonical
ensembl
ENSG00000161610
resolver
ensp
ENSP00000293330
resolver
enst
ENST00000293330
resolver
genesymbol
HCRT
resolver
genesymbol_syn
OX
resolver
genesymbol_syn
PPORX
resolver
genesymbol_syn
PPOX
resolver
hgnc
HGNC:4847
resolver
uniprot_entry
OREX_HUMAN
resolver
amino_acid_sequence
MNLPSTKVSWAAVTLLLLLLLLPPALLSSGAAAQPLPDCCRQKTCSCRLYELLHGAGNHAAGILTLGKRRSGPPGLQGRLQRLLQASGNHAAGILTMGRRAGAEPAPRPCLGRRCSAPAAASVAPGGQSGI
uniprot
proteins
disease_involvement
DISEASE: Narcolepsy 1 (NRCLP1) [MIM:161400]: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. {ECO:0000269|PubMed:10973318}. Note=The disease is caused by variants affecting the gene represented in this entry. Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients.
uniprot
proteins
function
FUNCTION: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. {ECO:0000250|UniProtKB:O55232}.; FUNCTION: [Orexin-A]: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity). {ECO:0000250|UniProtKB:O55232}.; FUNCTION: [Orexin-B]: Binds to orexin receptor HCRTR2/OX2R only (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity). {ECO:0000250|UniProtKB:O55232}.
uniprot
proteins
mass_dalton
13363
uniprot
proteins
post_translational_modification
PTM: Specific enzymatic cleavages at paired basic residues yield the different active peptides. {ECO:0000303|PubMed:9491897}.
uniprot
proteins
protein_family
Orexin family
uniprot
proteins
pubmed
10364220
uniprot
proteins
pubmed
10583376
uniprot
proteins
pubmed
10973318
uniprot
proteins
pubmed
11283317
uniprot
proteins
pubmed
11340621
uniprot
proteins
pubmed
14769912
uniprot
proteins
pubmed
15479620
uniprot
proteins
pubmed
16429482
uniprot
proteins
pubmed
33547286
uniprot
proteins
pubmed
9491897
uniprot
proteins
sequence_length
131
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Rough endoplasmic reticulum {ECO:0000250|UniProtKB:O55232}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:O55232}. Synapse {ECO:0000250|UniProtKB:O55232}. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000250|UniProtKB:O55232}.
uniprot
proteins