Gp2
entrez
67133
canonical
uniprot
Q9D733
canonical
ensembl
ENSMUSG00000030954
resolver
ensp
ENSMUSP00000033255
resolver
ensp
ENSMUSP00000159355
resolver
enst
ENSMUST00000033255
resolver
enst
ENSMUST00000239424
resolver
genesymbol
Gp2
resolver
uniprot
A0A0R4J0B9
resolver
uniprot_entry
A0A0R4J0B9_MOUSE
resolver
uniprot_entry
GP2_MOUSE
resolver
amino_acid_sequence
MVGCDLLWLAAASCVLTLVSPSTIHQGYGRPRNSSNLDLDCGSPDSPSSGICFDPCQNHTVLNDPTRSTENNDSSVAWCDDNLHGWYRFVGDGGVKMPETCVSVFRCHTSAPMWLSGSHPILGDGIVSHTACANWNENCCFWRSEVQVKACSEELGEYHVYKLQGTPECSLRYCTDPSTAPKNCEITCRPEEECVFQNNNWSCVCRQDLHVSDSQSLQPLLDCGDNEIKVKLDKCLLGGMGFKEEIIAYLNDRNCNGTMQDEPNNWVSMTSPVVANYCGNILEKNGTHAIYRNTLSLATDFIIRDFRVNVNFQCAYPLDMSVSLETALQPIVSSLTVDVDGAGEFNVKMALFQDQSYTNPYEGAEVLLPVESILYVGVLLNRGDTSRFKLLLTNCYATPSEDRHDPVKYFIIKNRCPNQRDSTINVRENGVSSESRFSVQMFMFAGNYDLVFLHCEVYLCDSTTEQCQPSCSTNRLRSSRPAIDYNRVLDLGPITKRSAQSSATSKGTPHTTGFLLAWPMFFLPVFLALLF
uniprot
proteins
function
FUNCTION: Functions as an intestinal M-cell transcytotic receptor specific of type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response. {ECO:0000269|PubMed:19907495}.
uniprot
proteins
mass_dalton
59154
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P19218}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19907495
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
531
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Zymogen granule membrane {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Secreted {ECO:0000250|UniProtKB:P19218}. Cell membrane {ECO:0000305|PubMed:19907495}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Apical cell membrane {ECO:0000269|PubMed:19907495}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Membrane raft {ECO:0000250|UniProtKB:P19218}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19218}. Endosome {ECO:0000305|PubMed:19907495}. Note=Secreted, after cleavage, in the pancreatic juice. {ECO:0000250|UniProtKB:P19218}.
uniprot
proteins