Q80YP0
uniprot
Q80YP0
canonical
amino_acid_sequence
MDVFQKVEKIGEGTYGVVYKARNKVTGQLVALKKIRLDLEAEGVPSTAVREISLLKELKHPNIIKLLDVVHREKKLYMVFEFLTQDLKRHMDSSPTSELPLPVVKSYLAQLLEGVSFCHSHRVIHRDLKPQNLLLDGLGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYSTAVDIWSIGCIFAEMVTGKALFPGDSEIDQLFRIFRTLGTPSEATWPGVSQMPDYQSSFPKWSRKGLEEIVPSLGPEGKDLLLRLLQYDPSQRISAKTALAHPYFSPGHSLAPQQCTAGRSSR
uniprot
proteins
ec_number
2.7.11.22
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. {ECO:0000269|PubMed:11733001}.
uniprot
proteins
mass_dalton
34075
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11172011
uniprot
proteins
pubmed
11733001
uniprot
proteins
pubmed
11955625
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
304
uniprot
proteins