Slc13a2
entrez
20500
canonical
uniprot
Q9ES88
canonical
ensembl
ENSMUSG00000001095
resolver
ensp
ENSMUSP00000001122
resolver
ensp
ENSMUSP00000348745
resolver
enst
ENSMUST00000001122
resolver
genesymbol
Slc13a2
resolver
genesymbol_syn
Nadc1
resolver
genesymbol_syn
Sdct1
resolver
uniprot_entry
S13A2_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Li(+) decreases succinate transport in the presence of Na(+), by competing at one of the three cation binding sites. Citrate transport is inhibited by N-(p-amylcinnamoyl) anthranilic acid (ACA). {ECO:0000250|UniProtKB:Q13183}.
uniprot
proteins
amino_acid_sequence
MATCWQALWAYRSYLIVLCLPIFLLPLPLIVQTKEAYCAYSIILMALLWCTEALPLAVTALFPIILFPLMGIMEASKVCLEYFKDTNILFVGGLMVAIAVEHWNLHKRIALGVLLIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMLPIGYAVLEQLQGSQKDVEEGNSNPSFELQEASPQKEETKLDNGQAVSVSSEPRAQKTKEHHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSIFPENSNVVNFASWFGFAFPTMVILLLLAWLWLQVLFLGVNFRKNFGFGEGEEERKQAAFQVIKTQHRLLGPMSFAEKAVTFLFVLLVVLWFTREPGFFPGWGDTAFANKKGQSMVSDGTVAIFISLIMFIIPSKIPGLTEDPKKPGKLKAPPAILTWKTVNDKMPWNILILLGGGFALAKGSEESGLSKWLGDKLTPLQHVPPSATVLILSLLVAIFTECTSNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLAFMLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLTITLSINSWSIPIFKLDTFPTWAYSNTSQCLLNPPNSTVPGH
uniprot
proteins
function
FUNCTION: Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (By similarity) (PubMed:10966927). Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood (PubMed:10966927). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (By similarity). Has a critical role in renal dicarboxylate transport (PubMed:17410095). {ECO:0000250|UniProtKB:Q13183, ECO:0000269|PubMed:10966927, ECO:0000269|PubMed:17410095}.
uniprot
proteins
mass_dalton
64111
uniprot
proteins
protein_family
NADC subfamily
uniprot
proteins
protein_family
SLC13A/DASS transporter (TC 2.A.47) family
uniprot
proteins
pubmed
10966927
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17410095
uniprot
proteins
sequence_length
586
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q13183}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..28; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 37..53; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 55..69; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 75..96; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 125..138; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 140..151; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 214..230; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 265..282; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 326..342; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 363..378; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 412..428; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 502..521; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183"; TRANSMEM 526..548; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13183
uniprot
proteins