Htr1b
entrez
15551
canonical
uniprot
P28334
canonical
ensembl
ENSMUSG00000049511
resolver
ensp
ENSMUSP00000050898
resolver
ensp
ENSMUSP00000139389
resolver
enst
ENSMUST00000051005
resolver
enst
ENSMUST00000183482
resolver
genesymbol
Htr1b
resolver
genesymbol_syn
5ht1b
resolver
uniprot
Q0VES5
resolver
uniprot_entry
5HT1B_MOUSE
resolver
uniprot_entry
Q0VES5_MOUSE
resolver
amino_acid_sequence
MEEQGIQCAPPPPAASQTGVPLTNLSHNCSADGYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVEYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEMLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRAPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCAG
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1557407, PubMed:17325130). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:1557407, PubMed:17325130). HTR1B is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (By similarity). Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (By similarity). Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior (PubMed:10651141, PubMed:16750486, PubMed:8091214, PubMed:8742487, PubMed:9349547). Besides, plays a role in vasoconstriction of cerebral arteries (By similarity). {ECO:0000250|UniProtKB:P28222, ECO:0000269|PubMed:10651141, ECO:0000269|PubMed:1557407, ECO:0000269|PubMed:16750486, ECO:0000269|PubMed:17325130, ECO:0000269|PubMed:8091214, ECO:0000269|PubMed:8742487, ECO:0000269|PubMed:9349547}.
uniprot
proteins
mass_dalton
43079
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation. {ECO:0000250|UniProtKB:P28222}.; PTM: Palmitoylated. {ECO:0000250|UniProtKB:P28222}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10651141
uniprot
proteins
pubmed
1557407
uniprot
proteins
pubmed
16750486
uniprot
proteins
pubmed
17325130
uniprot
proteins
pubmed
8091214
uniprot
proteins
pubmed
8742487
uniprot
proteins
pubmed
9349547
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1557407, ECO:0000269|PubMed:17325130}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..68; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P28222"; TRANSMEM 83..107; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P28222"; TRANSMEM 116..141; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P28222"; TRANSMEM 162..180; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P28222"; TRANSMEM 202..225; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P28222"; TRANSMEM 312..333; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P28222"; TRANSMEM 344..366; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P28222
uniprot
proteins