IYD
entrez
389434
canonical
uniprot
Q6PHW0
canonical
ensembl
ENSG00000009765
resolver
ensp
ENSP00000229447
resolver
ensp
ENSP00000343763
resolver
ensp
ENSP00000376085
resolver
genesymbol
DEHAL1
resolver
genesymbol
IYD
resolver
genesymbol_syn
C6orf71
resolver
genesymbol_syn
DEHAL1
resolver
hgnc
HGNC:21071
resolver
uniprot
C9JFW2
resolver
uniprot
Q2VPV9
resolver
uniprot
Q2VPW0
resolver
uniprot
Q2VPW1
resolver
uniprot
Q5F1L5
resolver
uniprot
Q5F1L6
resolver
uniprot
Q5THM4
resolver
uniprot
Q6ZP69
resolver
uniprot
Q7Z7D7
resolver
uniprot
Q7Z7D8
resolver
uniprot_entry
IYD1_HUMAN
resolver
uniprot_entry
Q2VPV9_HUMAN
resolver
uniprot_sec
C9JFW2
resolver
uniprot_sec
Q2VPW0
resolver
uniprot_sec
Q2VPW1
resolver
uniprot_sec
Q5F1L5
resolver
uniprot_sec
Q5F1L6
resolver
uniprot_sec
Q5THM4
resolver
uniprot_sec
Q6ZP69
resolver
uniprot_sec
Q7Z7D7
resolver
uniprot_sec
Q7Z7D8
resolver
amino_acid_sequence
MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEEDADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTV
uniprot
proteins
disease_involvement
DISEASE: Thyroid dyshormonogenesis 4 (TDH4) [MIM:274800]: A disorder due to thyroid dyshormonogenesis, causing severe hypothyroidism, goiter, excessive levels of iodotyrosine in serum and urine, and variable mental deficits derived from unrecognized and untreated hypothyroidism. {ECO:0000269|PubMed:18434651}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.21.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (PubMed:15289438, PubMed:18434651, PubMed:25395621, PubMed:28157283). During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) (PubMed:15289438, PubMed:18434651). The scavanged iodide can then reenter the hormone-producing pathways (PubMed:15289438, PubMed:18434651). Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine (PubMed:15289438). {ECO:0000269|PubMed:15289438, ECO:0000269|PubMed:18434651, ECO:0000269|PubMed:25395621, ECO:0000269|PubMed:28157283}.
uniprot
proteins
mass_dalton
33360
uniprot
proteins
mutagenesis
MUTAGEN 101; /note="R->A: Strongly reduces activity."; /evidence="ECO:0000269|PubMed:18434651"; MUTAGEN 101; /note="R->H: Reduces activity."; /evidence="ECO:0000269|PubMed:18434651"; MUTAGEN 105; /note="F->A: Activity as the wild type."; /evidence="ECO:0000269|PubMed:18434651"; MUTAGEN 105; /note="F->Y: Activity as the wild type."; /evidence="ECO:0000269|PubMed:18434651"; MUTAGEN 116; /note="I->V: Activity as the wild type."; /evidence="ECO:0000269|PubMed:18434651
uniprot
proteins
protein_family
Nitroreductase family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15289438
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18434651
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25395621
uniprot
proteins
pubmed
28157283
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15289438}; Single-pass membrane protein {ECO:0000269|PubMed:15289438}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:15289438}.
uniprot
proteins
transmembrane_region
TRANSMEM 1..21; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins