Slc16a12
entrez
240638
canonical
uniprot
Q8BGC3
canonical
ensembl
ENSMUSG00000009378
resolver
ensp
ENSMUSP00000009522
resolver
ensp
ENSMUSP00000216324
resolver
ensp
ENSMUSP00000216328
resolver
enst
ENSMUST00000009522
resolver
genesymbol
Slc16a12
resolver
genesymbol_syn
Mct12
resolver
uniprot
Q14CF9
resolver
uniprot
Q14DR7
resolver
uniprot_entry
MOT12_MOUSE
resolver
uniprot_sec
Q14CF9
resolver
uniprot_sec
Q14DR7
resolver
activity_regulation
ACTIVITY REGULATION: Creatine uptake is inhibited by carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and by valinomycin. {ECO:0000250|UniProtKB:Q6ZSM3}.
uniprot
proteins
amino_acid_sequence
MTKITRVSLASPPDGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDRSVPEKNHNRESQREDCKQASPYSPLTKECTETRLCCSLQQEYGFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFVRIVKRMKRTQVPFPVKDSDPKLQLWTNGSVAYSVARELDQKDEEPLPKARSGCNLT
uniprot
proteins
function
FUNCTION: Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution. {ECO:0000250|UniProtKB:Q6ZSM3}.
uniprot
proteins
mass_dalton
53152
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21778275
uniprot
proteins
pubmed
26376857
uniprot
proteins
sequence_length
486
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6ZSM3}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:26376857}; Multi-pass membrane protein {ECO:0000255}. Note=Interaction with isoform 2 of BSG is required for its localization to the plasma membrane. {ECO:0000250|UniProtKB:Q6ZSM3}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 58..78; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 86..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 148..168; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 253..273; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 320..340; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 353..373; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 383..403; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 410..430; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins