DNMT3L
entrez
29947
canonical
uniprot
Q9UJW3
canonical
ensembl
ENSG00000142182
resolver
ensp
ENSP00000270172
resolver
ensp
ENSP00000486001
resolver
genesymbol
DNMT3L
resolver
hgnc
HGNC:2980
resolver
uniprot
E9PB42
resolver
uniprot
Q9BUJ4
resolver
uniprot_entry
DNM3L_HUMAN
resolver
uniprot_sec
E9PB42
resolver
uniprot_sec
Q9BUJ4
resolver
amino_acid_sequence
MAAIPALDPEAEPSMDVILVGSSELSSSVSPGTGRDLIAYEVKANQRNIEDICICCGSLQVHTQHPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSGETLLICGNPDCTRCYCFECVDSLVGPGTSGKVHAMSNWVCYLCLPSSRSGLLQRRRKWRSQLKAFYDRESENPLEMFETVPVWRRQPVRVLSLFEDIKKELTSLGFLESGSDPGQLKHVVDVTDTVRKDVEEWGPFDLVYGATPPLGHTCDRPPSWYLFQFHRLLQYARPKPGSPRPFFWMFVDNLVLNKEDLDVASRFLEMEPVTIPDVHGGSLQNAVRVWSNIPAIRSRHWALVSEEELSLLAQNKQSSKLAAKWPTKLVKNCFLPLREYFKYFSTELTSSL
uniprot
proteins
function
FUNCTION: Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By similarity). Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:17687327). Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:17687327). Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (PubMed:17687327). Plays a key role in embryonic stem cells and germ cells (By similarity). In germ cells, required for the methylation of imprinted loci together with DNMT3A (By similarity). In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (By similarity). Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation (By similarity). While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (By similarity). Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (By similarity). Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (By similarity). {ECO:0000250|UniProtKB:Q9CWR8, ECO:0000269|PubMed:17687327}.
uniprot
proteins
mass_dalton
43583
uniprot
proteins
mutagenesis
MUTAGEN 261; /note="F->A: Loss of binding to DNMT3A."; /evidence="ECO:0000269|PubMed:17713477
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
10857753
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17687327
uniprot
proteins
pubmed
17713477
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins