Crb1
entrez
170788
canonical
uniprot
Q8VHS2
canonical
ensembl
ENSMUSG00000063681
resolver
ensp
ENSMUSP00000060769
resolver
ensp
ENSMUSP00000142552
resolver
genesymbol
Crb1
resolver
uniprot
A0A7D6VMF7
resolver
uniprot
A0A7D6VRP0
resolver
uniprot
B7ZC63
resolver
uniprot
Q6ST50
resolver
uniprot
Q71JF2
resolver
uniprot
Q7TSG9
resolver
uniprot
Q8BGR4
resolver
uniprot_entry
A0A7D6VMF7_MOUSE
resolver
uniprot_entry
A0A7D6VRP0_MOUSE
resolver
uniprot_entry
CRUM1_MOUSE
resolver
uniprot_entry
Q7TSG9_MOUSE
resolver
uniprot_sec
B7ZC63
resolver
uniprot_sec
Q6ST50
resolver
uniprot_sec
Q71JF2
resolver
uniprot_sec
Q8BGR4
resolver
amino_acid_sequence
MKLKRTAYLLFLYLSSSLLICIKNSFCNKNNTRCLSGPCQNNSTCKHFPQDNNCCLDTANNLDKDCEDLKDPCFSSPCQGIATCVKIPGEGNFLCQCPPGYSGLNCETATNSCGGNLCQHGGTCRKDPEHPVCICPPGYAGRFCETDHNECASSPCHNGAMCQDGINGYSCFCVPGYQGRHCDLEVDECVSDPCKNEAVCLNEIGRYTCVCPQEFSGVNCELEIDECRSQPCLHGATCQDAPGGYSCDCAPGFLGEHCELSVNECESQPCLHGGLCVDGRNSYHCDCTGSGFTGMHCESLIPLCWSKPCHNDATCEDTVDSYICHCRPGYTGALCETDINECSSNPCQFWGECVELSSEGLYGNTAGLPSSFSYVGASGYVCICQPGFTGIHCEEDVDECLLHPCLNGGTCENLPGNYACHCPFDDTSRTFYGGENCSEILLGCTHHQCLNNGKCIPHFQNGQHGFTCQCLSGYAGPLCETVTTLSFGSNGFLWVTSGSHTGIGPECNISLRFHTVQPNALLLIRGNKDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTIAETLTLALVGGSCKEKCTTKSSVPVENHQSICALQDSFLGGLPMGTANNSVSVLNIYNVPSTPSFVGCLQDIRFDLNHITLENVSSGLSSNVKAGCLGKDWCESQPCQNRGRCINLWQGYQCECDRPYTGSNCLKEYVAGRFGQDDSTGYAAFSVNDNYGQNFSLSMFVRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFFLSDGNVHLISLRIKPNEIELYQSSQNLGFISVPTWTIRRGDVIFIGGLPDREKTEVYGGFFKGCVQDVRLNSQTLEFFPNSTNNAYDDPILVNVTQGCPGDNTCKSNPCHNGGVCHSLWDDFSCSCPTNTAGRACEQVQWCQLSPCPPTAECQLLPQGFECIANAVFSGLSREILFRSNGNITRELTNITFAFRTHDTNVMILHAEKEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLVNDGTWHQVTFSMIDPVAQTSRWQMEVNDQTPFVISEVATGSLNFLKDNTDIYVGDQSVDNPKGLQGCLSTIEIGGIYLSYFENLHGFPGKPQEEQFLKVSTNMVLTGCLPSNACHSSPCLHGGNCEDSYSSYRCACLSGWSGTHCEINIDECFSSPCIHGNCSDGVAAYHCRCEPGYTGVNCEVDVDNCKSHQCANGATCVPEAHGYSCLCFGNFTGRFCRHSRLPSTVCGNEKRNFTCYNGGSCSMFQEDWQCMCWPGFTGEWCEEDINECASDPCINGGLCRDLVNRFLCICDVAFAGERCELDLADDRLLGIFTAVGSGTLALFFILLLAGVASLIASNKRATQGTYSPSGQEKAGPRVEMWIRMPPPALERLI
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Crb1 are a cause of focal retinal dysplasia and degeneration associated with a shortening of inner and outer segments. Affected mice produce a secreted truncated protein that lacks the single transmembrane and the intracellular domain, and develop irregularities at the outer limiting membrane and loss of photoreceptor cells. {ECO:0000269|PubMed:12915475}.
uniprot
proteins
function
FUNCTION: Plays a role in photoreceptor morphogenesis in the retina (PubMed:12915475). May maintain cell polarization and adhesion (PubMed:15316081). {ECO:0000269|PubMed:12915475, ECO:0000269|PubMed:15316081}.; FUNCTION: [Isoform 3]: May play a role in epidermal tissue morphogenesis (PubMed:14684155). May function in cell attachment for stratified epithelial organization (PubMed:14684155). {ECO:0000269|PubMed:14684155}.
uniprot
proteins
mass_dalton
153350
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:P82279}.
uniprot
proteins
protein_family
Crumbs protein family
uniprot
proteins
pubmed
11744384
uniprot
proteins
pubmed
11850625
uniprot
proteins
pubmed
12915475
uniprot
proteins
pubmed
14684155
uniprot
proteins
pubmed
15316081
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23001562
uniprot
proteins
pubmed
26404741
uniprot
proteins
sequence_length
1405
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Apical cell membrane {ECO:0000269|PubMed:11850625}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000305}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:11850625}. Photoreceptor inner segment {ECO:0000269|PubMed:11850625}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:14684155}. Cytoplasm {ECO:0000269|PubMed:14684155}. Cell junction, focal adhesion {ECO:0000269|PubMed:14684155}. Note=Found in the cytoplasmic area of undifferentiated keratinocytes and associated with the plasma membrane at the site of cell-cell contacts and focal adhesion upon keratinocytes differentiation. {ECO:0000269|PubMed:14684155}.
uniprot
proteins
transmembrane_region
TRANSMEM 1340..1360; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins