Msrb1
entrez
27361
canonical
uniprot
Q9JLC3
canonical
ensembl
ENSMUSG00000075705
resolver
ensp
ENSMUSP00000099300
resolver
ensp
ENSMUSP00000110917
resolver
genesymbol
Msrb1
resolver
genesymbol_syn
Sepr
resolver
genesymbol_syn
Sepx1
resolver
uniprot
Q545U8
resolver
uniprot_entry
MSRB1_MOUSE
resolver
uniprot_sec
Q545U8
resolver
amino_acid_sequence
MSFCSFFGGEVFQNHFEPGVYVCAKCSYELFSSHSKYAHSSPWPAFTETIHPDSVTKCPEKNRPEALKVSCGKCGNGLGHEFLNDGPKRGQSRFUIFSSSLKFVPKGKEAAASQGH
uniprot
proteins
ec_number
1.8.4.12
uniprot
proteins
ec_number
1.8.4.14
uniprot
proteins
function
FUNCTION: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine (PubMed:11929995, PubMed:14699060, PubMed:20605785, PubMed:23911929). While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue (PubMed:14699060, PubMed:20605785). Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization (PubMed:23911929). Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages (PubMed:23911929). {ECO:0000269|PubMed:11929995, ECO:0000269|PubMed:14699060, ECO:0000269|PubMed:20605785, ECO:0000269|PubMed:23911929}.
uniprot
proteins
mass_dalton
12788
uniprot
proteins
mutagenesis
MUTAGEN 95; /note="U->C: Optimum pH 7.5."; /evidence="ECO:0000269|PubMed:20605785
uniprot
proteins
post_translational_modification
PTM: Truncated MSRB1/SEPX1 proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(FEM1C) E3 ubiquitin-protein ligase complex. {ECO:0000250|UniProtKB:Q9NZV6}.
uniprot
proteins
protein_family
MsrB Met sulfoxide reductase family
uniprot
proteins
pubmed
10567350
uniprot
proteins
pubmed
11929995
uniprot
proteins
pubmed
14699060
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19636847
uniprot
proteins
pubmed
20605785
uniprot
proteins
pubmed
23911929
uniprot
proteins
sequence_length
116
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14699060}. Nucleus {ECO:0000269|PubMed:14699060}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23911929}.
uniprot
proteins