Psmc3
entrez
19182
canonical
uniprot
O88685
canonical
ensembl
ENSMUSG00000002102
resolver
ensp
ENSMUSP00000071054
resolver
enst
ENSMUST00000067663
resolver
genesymbol
Psmc3
resolver
genesymbol_syn
Tbp1
resolver
uniprot
Q3TKG4
resolver
uniprot
Q99JN8
resolver
uniprot_entry
PRS6A_MOUSE
resolver
uniprot_entry
Q3TKG4_MOUSE
resolver
uniprot_sec
Q99JN8
resolver
amino_acid_sequence
MQEMNLLPTPESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIVQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000250|UniProtKB:P17980}.
uniprot
proteins
mass_dalton
49549
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
10945464
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16857966
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22078707
uniprot
proteins
pubmed
9714759
uniprot
proteins
sequence_length
442
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Colocalizes with TRIM5 in cytoplasmic bodies. {ECO:0000269|PubMed:22078707}.
uniprot
proteins