LPGAT1
entrez
9926
canonical
uniprot
Q92604
canonical
ensembl
ENSG00000123684
resolver
ensp
ENSP00000355963
resolver
ensp
ENSP00000355964
resolver
ensp
ENSP00000560097
resolver
ensp
ENSP00000560098
resolver
ensp
ENSP00000560100
resolver
ensp
ENSP00000560101
resolver
ensp
ENSP00000560103
resolver
ensp
ENSP00000560104
resolver
ensp
ENSP00000560107
resolver
ensp
ENSP00000560109
resolver
ensp
ENSP00000583593
resolver
ensp
ENSP00000637960
resolver
ensp
ENSP00000637962
resolver
enst
ENST00000366996
resolver
enst
ENST00000366997
resolver
enst
ENST00000890038
resolver
enst
ENST00000890039
resolver
enst
ENST00000890041
resolver
enst
ENST00000890042
resolver
enst
ENST00000890044
resolver
enst
ENST00000890045
resolver
enst
ENST00000890048
resolver
enst
ENST00000890051
resolver
enst
ENST00000913534
resolver
enst
ENST00000967901
resolver
enst
ENST00000967903
resolver
genesymbol
LPGAT1
resolver
genesymbol_syn
FAM34A
resolver
genesymbol_syn
KIAA0205
resolver
hgnc
HGNC:28985
resolver
uniprot
Q53YL2
resolver
uniprot_entry
LGAT1_HUMAN
resolver
uniprot_sec
Q53YL2
resolver
amino_acid_sequence
MAITLEEAPWLGWLLVKALMRFAFMVVNNLVAIPSYICYVIILQPLRVLDSKRFWYIEGIMYKWLLGMVASWGWYAGYTVMEWGEDIKAVSKDEAVMLVNHQATGDVCTLMMCLQDKGLVVAQMMWLMDHIFKYTNFGIVSLVHGDFFIRQGRSYRDQQLLLLKKHLENNYRSRDRKWIVLFPEGGFLRKRRETSQAFAKKNNLPFLTNVTLPRSGATKIILNALVAQQKNGSPAGGDAKELDSKSKGLQWIIDTTIAYPKAEPIDIQTWILGYRKPTVTHVHYRIFPIKDVPLETDDLTTWLYQRFVEKEDLLSHFYETGAFPPSKGHKEAVSREMTLSNLWIFLIQSFAFLSGYMWYNIIQYFYHCLF
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.22
uniprot
proteins
ec_number
2.3.1.62
uniprot
proteins
function
FUNCTION: Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane (By similarity). Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor (PubMed:36049524). Acts in concert with an unknown phospholipase A1 to convert palmitate phosphatidylethanolamine (PE) species into stearate ones. Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span (By similarity). Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors (PubMed:15485873). Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols (By similarity). Has no activity toward lysophosphatidic acids (LPA) (By similarity). {ECO:0000250|UniProtKB:Q91YX5, ECO:0000269|PubMed:15485873, ECO:0000269|PubMed:36049524}.
uniprot
proteins
mass_dalton
43089
uniprot
proteins
protein_family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
uniprot
proteins
pubmed
15485873
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
34890643
uniprot
proteins
pubmed
36049524
uniprot
proteins
pubmed
9039502
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15485873}; Multi-pass membrane protein {ECO:0000269|PubMed:15485873}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 342..362; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins