Klhl41
entrez
228003
canonical
uniprot
A2AUC9
canonical
ensembl
ENSMUSG00000075307
resolver
ensp
ENSMUSP00000097627
resolver
enst
ENSMUST00000100050
resolver
genesymbol
Klhl41
resolver
genesymbol_syn
Kbtbd10
resolver
uniprot
B2RWT7
resolver
uniprot_entry
KLH41_MOUSE
resolver
uniprot_sec
B2RWT7
resolver
amino_acid_sequence
MDSQRELAEELRLYQSTLLQDGLKDLLEEKKFIDCTLKAGDKSFPCHRLILSACSPYFREYFLSEIEEEKKKEVALDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALSSRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEVVFEAVMKWVRTDKENRAKNLSEVFDCIRFRLMAEKYFKDHVEKDDIIKSNPEVQKKIKVLKDAFAGKLPEPSKNAEKAGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPMENECYLTALAEQIPRNHSSLVTQQNQVYVVGGLYVDEENKDQPLQSYFFQLDNVTSEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWSEVKNLPIKVYGHNVISHNGMIYCLGGKTDDKKCTNRVFIYNPKKGDWKDLAPMKTPRSMFGVAIHKGKIVIAGGVTEDGLSASVEAFDLKTNKWEVMTEFPQERSSISLVSLAGALYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNLFKLSKL
uniprot
proteins
function
FUNCTION: Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. {ECO:0000269|PubMed:18178185, ECO:0000269|PubMed:21368295, ECO:0000269|PubMed:22562206}.
uniprot
proteins
mass_dalton
68190
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination. {ECO:0000250|UniProtKB:O60662}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18178185
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21368295
uniprot
proteins
pubmed
22562206
uniprot
proteins
pubmed
24268659
uniprot
proteins
sequence_length
606
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18178185, ECO:0000269|PubMed:22562206}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18178185}. Cell projection, pseudopodium {ECO:0000250|UniProtKB:Q9ER30}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9ER30}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:22562206}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:24268659}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24268659}. Note=Predominantly cytoplasmic but can colocalize with F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia.
uniprot
proteins