Map2k5
entrez
23938
canonical
uniprot
Q9WVS7
canonical
ensembl
ENSMUSG00000058444
resolver
ensp
ENSMUSP00000034920
resolver
ensp
ENSMUSP00000226846
resolver
ensp
ENSMUSP00000226848
resolver
ensp
ENSMUSP00000226851
resolver
ensp
ENSMUSP00000226857
resolver
ensp
ENSMUSP00000226877
resolver
ensp
ENSMUSP00000226894
resolver
genesymbol
Map2k5
resolver
genesymbol_syn
Mek5
resolver
genesymbol_syn
Mkk5
resolver
genesymbol_syn
Prkmk5
resolver
uniprot
Q8CFM3
resolver
uniprot
Q8K360
resolver
uniprot
Q9D222
resolver
uniprot_entry
MP2K5_MOUSE
resolver
uniprot_sec
Q8CFM3
resolver
uniprot_sec
Q8K360
resolver
uniprot_sec
Q9D222
resolver
amino_acid_sequence
MLWLALGPFCAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHTSPVVSDSLPSNSLKKSSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAHHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTGGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPLGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNSTVVSMWVCRALEERRSQQGPP
uniprot
proteins
ec_number
2.7.12.2
uniprot
proteins
function
FUNCTION: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). {ECO:0000250|UniProtKB:Q62862, ECO:0000269|PubMed:10473620, ECO:0000269|PubMed:16507987}.
uniprot
proteins
mass_dalton
50105
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="R->A: Loss of MAPK7 binding; when associated with A-21."; /evidence="ECO:0000269|PubMed:16507987"; MUTAGEN 21; /note="I->A: Loss of MAPK7 binding; when associated with A-20."; /evidence="ECO:0000269|PubMed:16507987"; MUTAGEN 64; /note="D->A: Loss of MAP3K2/MAP3K3 binding; when associated with A-65."; /evidence="ECO:0000269|PubMed:16507987"; MUTAGEN 65; /note="E->A: Loss of MAP3K2/MAP3K3 binding; when associated with A-64."; /evidence="ECO:0000269|PubMed:16507987"; MUTAGEN 67; /note="G->A: Loss of MAP3K2/MAP3K3 binding; when associated with A-68."; /evidence="ECO:0000269|PubMed:16507987"; MUTAGEN 68; /note="D->A: Loss of MAP3K2/MAP3K3 binding; when associated with A-67."; /evidence="ECO:0000269|PubMed:16507987"; MUTAGEN 311; /note="S->A: Dominant negative form; when associated with V-315."; /evidence="ECO:0000269|PubMed:10473620"; MUTAGEN 311; /note="S->D: Dominant active form; when associated with D-315."; /evidence="ECO:0000269|PubMed:10473620"; MUTAGEN 315; /note="T->D: Dominant active form; when associated with D-311."; /evidence="ECO:0000269|PubMed:10473620"; MUTAGEN 315; /note="T->V: Dominant negative form; when associated with A-311."; /evidence="ECO:0000269|PubMed:10473620
uniprot
proteins
post_translational_modification
PTM: Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. {ECO:0000250}.
uniprot
proteins
protein_family
MAP kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
10473620
uniprot
proteins
pubmed
12813044
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16507987
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins