Spred1
entrez
114715
canonical
uniprot
Q924S8
canonical
ensembl
ENSMUSG00000027351
resolver
ensp
ENSMUSP00000028829
resolver
ensp
ENSMUSP00000106526
resolver
genesymbol
Spred1
resolver
uniprot
Q3U2W6
resolver
uniprot
Q6PET8
resolver
uniprot_entry
SPRE1_MOUSE
resolver
uniprot_sec
Q3U2W6
resolver
uniprot_sec
Q6PET8
resolver
amino_acid_sequence
MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFRVPHQEENGCADFFIRGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAIEDISLGCPASKTEAEGGDDDLQTTEEDTSRSLVKDHFFQQETVVTSEPYRSSDIRPLPFEDLNARRVYLQSQVSQIPFSQQGLDIQSRSMEYVQRQISKECGSLKSQTRVPLKSIRHVSFQDEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDTDSSVPFSKQDSKKSDYLYHCGDETKLSSLKDSVVFKTQPPSLKFKSKRRKEDGERSRCVYCQERFNHEENARGKCQDAPDPVKRCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLALVALSFIVPCMCCYVPLRMCHRCGEACGCCGGKHKAAG
uniprot
proteins
function
FUNCTION: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (PubMed:11493923). Negatively regulates hematopoiesis of bone marrow (PubMed:15465815). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (PubMed:29501879). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (PubMed:25576668). {ECO:0000250|UniProtKB:Q7Z699, ECO:0000269|PubMed:11493923, ECO:0000269|PubMed:15465815, ECO:0000269|PubMed:25576668, ECO:0000269|PubMed:29501879}.
uniprot
proteins
mass_dalton
50664
uniprot
proteins
post_translational_modification
PTM: Palmitoylated by ZDHHC17/HIP14. {ECO:0000269|PubMed:24705354}.; PTM: Ubiquitinated. {ECO:0000250|UniProtKB:Q7Z699}.; PTM: Phosphorylated on tyrosine. {ECO:0000269|PubMed:11493923}.
uniprot
proteins
pubmed
11493923
uniprot
proteins
pubmed
12646235
uniprot
proteins
pubmed
15465815
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15580519
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17974561
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24705354
uniprot
proteins
pubmed
25576668
uniprot
proteins
pubmed
29501879
uniprot
proteins
sequence_length
444
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11493923}; Peripheral membrane protein {ECO:0000269|PubMed:11493923}. Membrane, caveola {ECO:0000269|PubMed:11493923}; Peripheral membrane protein {ECO:0000269|PubMed:11493923}. Nucleus {ECO:0000269|PubMed:11493923}. Note=Localized in cholesterol-rich membrane raft/caveola fractions. {ECO:0000250}.
uniprot
proteins