Dnajb14
entrez
70604
canonical
uniprot
Q149L6
canonical
ensembl
ENSMUSG00000074212
resolver
ensp
ENSMUSP00000087641
resolver
ensp
ENSMUSP00000338208
resolver
genesymbol
Dnajb14
resolver
uniprot
Q3TU54
resolver
uniprot
Q3UTE5
resolver
uniprot_entry
DJB14_MOUSE
resolver
uniprot_sec
Q3TU54
resolver
uniprot_sec
Q3UTE5
resolver
amino_acid_sequence
MEGNRDEAEKCVQIAREALSAGNRDKAQRFLQKAEKLYPLPAARALLEIIMKNGSTAGSSTHCRKPPGSSDQSKPSCGKDGTSGAGEGGKVYTKDQVEGVLSINKCKNYYEVLGVTKDAGDEDLKKAYRKLALKFHPDKNHAPGATDAFKKIGNAYAVLSNPEKRKQYDLTGSEEQACNHQNNGRFNFHRGCEADITPEDLFNIFFGGGFPSGSVHSFSNGRAAYSHQHQHRHSGHEREEERADGGFSVFIQLMPIIVLILVSLLSQLMVSNPPYSLYPRSGSGQTIKMQTENLGVVYYVSKDFKSEYKGTLLQKVEKSVEEDYVTNIRNNCWKERQQKTDMQYAAKVYRDEQLRRKADALSMENCKELERLTSLYKGG
uniprot
proteins
function
FUNCTION: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear. {ECO:0000250|UniProtKB:Q8TBM8}.
uniprot
proteins
mass_dalton
42326
uniprot
proteins
protein_family
DNAJB12/DNAJB14 subfamily
uniprot
proteins
protein_family
DnaJ family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8TBM8}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:Q8TBM8}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to the endoplasmic reticulum membrane. When overexpressed, forms membranous structures in the nucleus. {ECO:0000250|UniProtKB:Q8TBM8}.
uniprot
proteins
transmembrane_region
TRANSMEM 245..265; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins