Tatdn1
entrez
69694
canonical
uniprot
Q6P8M1
canonical
ensembl
ENSMUSG00000050891
resolver
ensp
ENSMUSP00000105783
resolver
ensp
ENSMUSP00000154677
resolver
ensp
ENSMUSP00000303014
resolver
ensp
ENSMUSP00000303023
resolver
ensp
ENSMUSP00000343002
resolver
enst
ENSMUST00000110155
resolver
genesymbol
Tatdn1
resolver
uniprot
A0A0R4J1E8
resolver
uniprot
Q8BY37
resolver
uniprot_entry
A0A0R4J1E8_MOUSE
resolver
uniprot_entry
TATD1_MOUSE
resolver
uniprot_sec
Q8BY37
resolver
amino_acid_sequence
MSLFKFVDIGINLTDPMFRGIYRGVQKHQDDLQDVIERAIQIGVKKFMITGGSLQDSKDALQLAQTNDMFFSTVGCHPTRCDEFEKGSPDQYLAGLLSLAENNKGKVVAIGECGLDFDRLQFCPKDTQLKYFEKQFELSEQTQLPMFLHCRNSHTEFLDIMRRNRDRYVGGVVHSFDGTKEAAAALVDLGLYIGFNGCSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYINTSFPTKKKWENGHCLKDRNEPCHIIQILEIMSAVREEDPLELANTLYNNTIKVFFS
uniprot
proteins
ec_number
3.1.11.-
uniprot
proteins
ec_number
3.1.21.-
uniprot
proteins
function
FUNCTION: Exhibits 3'-5' exonuclease and apurinic/apyrimidinic (AP) endonuclease activities (in vitro). Shows preferential AP endonuclease activity on dsDNA substrates and 3'-5'exonuclease activity on ssDNA (By similarity). Catalyzes decatenation of catenated kinetoplast DNA to produce separated linear DNA in vitro. Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity (By similarity). {ECO:0000250|UniProtKB:Q6GML7, ECO:0000250|UniProtKB:Q6P1N9}.
uniprot
proteins
mass_dalton
33365
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
protein_family
TatD-type hydrolase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins