Fgf13
entrez
14168
canonical
uniprot
P70377
canonical
ensembl
ENSMUSG00000031137
resolver
ensp
ENSMUSP00000033473
resolver
ensp
ENSMUSP00000113206
resolver
ensp
ENSMUSP00000113639
resolver
genesymbol
Fgf13
resolver
genesymbol_syn
Fhf2
resolver
uniprot
B1AU21
resolver
uniprot
O35338
resolver
uniprot
Q3UR31
resolver
uniprot
Q8VCY9
resolver
uniprot
Q9JLA5
resolver
uniprot_entry
FGF13_MOUSE
resolver
uniprot_sec
B1AU21
resolver
uniprot_sec
O35338
resolver
uniprot_sec
Q3UR31
resolver
uniprot_sec
Q8VCY9
resolver
uniprot_sec
Q9JLA5
resolver
amino_acid_sequence
MAAAIASSLIRQKRQAREREKSNACKCVSSPSKGKTSCDKNKLNVFSRVKLFGSKKRRRRRPEPQLKGIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSEHFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST
uniprot
proteins
function
FUNCTION: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (PubMed:22726441). Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching (PubMed:22726441). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (PubMed:22726441). Regulates voltage-gated sodium channel transport and function (PubMed:21817159). May also play a role in MAPK signaling (PubMed:11378392, PubMed:12244047). Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (PubMed:30679375). {ECO:0000269|PubMed:11378392, ECO:0000269|PubMed:12244047, ECO:0000269|PubMed:21817159, ECO:0000269|PubMed:22726441, ECO:0000269|PubMed:30679375}.; FUNCTION: [Isoform 1]: Does not seem to be involved in neuroblast polarization and migration but regulates axon branching. {ECO:0000269|PubMed:22726441}.
uniprot
proteins
mass_dalton
27588
uniprot
proteins
post_translational_modification
PTM: May be phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
Heparin-binding growth factors family
uniprot
proteins
pubmed
10644718
uniprot
proteins
pubmed
11378392
uniprot
proteins
pubmed
12244047
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21817159
uniprot
proteins
pubmed
22726441
uniprot
proteins
pubmed
30679375
uniprot
proteins
pubmed
8790420
uniprot
proteins
pubmed
9232594
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, filopodium {ECO:0000269|PubMed:22726441}. Cell projection, growth cone {ECO:0000269|PubMed:22726441}. Cell projection, dendrite {ECO:0000269|PubMed:22726441}. Cell membrane, sarcolemma {ECO:0000269|PubMed:21817159}. Cytoplasm {ECO:0000269|PubMed:22726441}. Note=Not secreted. Localizes to the lateral membrane and intercalated disks of myocytes. {ECO:0000269|PubMed:22726441}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:Q92913}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:Q92913}. Nucleus {ECO:0000250|UniProtKB:Q92913}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:10644718}. Nucleus {ECO:0000269|PubMed:10644718}.
uniprot
proteins