Nos2
entrez
24599
canonical
uniprot
Q06518
canonical
ensembl
ENSRNOG00000057443
resolver
ensembl
ENSRNOG00055025134
resolver
ensembl
ENSRNOG00060019106
resolver
ensp
ENSRNOP00000016133
resolver
ensp
ENSRNOP00000067662
resolver
ensp
ENSRNOP00055035578
resolver
ensp
ENSRNOP00060027661
resolver
enst
ENSRNOT00000016133
resolver
enst
ENSRNOT00055043587
resolver
enst
ENSRNOT00060033771
resolver
genesymbol
Nos2
resolver
uniprot
F1LSH9
resolver
uniprot
O35765
resolver
uniprot
O35766
resolver
uniprot
O60591
resolver
uniprot
O60604
resolver
uniprot
P97774
resolver
uniprot
Q63267
resolver
uniprot
Q64005
resolver
uniprot
Q64558
resolver
uniprot_entry
F1LSH9_RAT
resolver
uniprot_entry
NOS2_RAT
resolver
uniprot_sec
O35765
resolver
uniprot_sec
O35766
resolver
uniprot_sec
O60591
resolver
uniprot_sec
O60604
resolver
uniprot_sec
P97774
resolver
uniprot_sec
Q63267
resolver
uniprot_sec
Q64005
resolver
uniprot_sec
Q64558
resolver
activity_regulation
ACTIVITY REGULATION: Not stimulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MACPWKFLFRVKSYQGDLKEEKDINNNVEKTPGAIPSPTTQDDPKSHKHQNGFPQFLTGTAQNVPESLDKLHVTPSTRPQHVRIKNWGNGEIFHDTLHHKATSDISCKSKLCMGSIMNSKSLTRGPRDKPTPVEELLPQAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVFDARSCSTASEMFQHICRHILYATNSGNIRSAITVFPQRSDGKHDFRIWNSQLIRYAGYQMPDGTIRGDPATLEFTQLCIDLGWKPRYGRFDVLPLVLQAHGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINAAVLHSFQKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLSPFYYYQIEPWKTHIWQDEKLRPRRREIRFTVLVKAVFFASVLMRKVMASRVRATVLFATETGKSEALARDLAALFSYAFNTKVVCMEQYKANTLEEEQLLLVVTSTFGNGDCPSNGQTLKKSLFMMKELGHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGDELSGQEDAFRSWAVQTFRAACETFDVRSKHCIQIPKRYTSNATWEPEQYKLTQSPESLDLNKALSSIHAKNVFTMRLKSLQNLQSEKSSRTTLLVQLTFEGSRGPSYLPGEHLGIFPGNQTALVQGILERVVDCSSPDQTVCLEVLDESGSYWVKDKRLPPCSLRQALTYFLDITTPPTQLQLHKLARFATEETHRQRLEALCQPSEYNDWKFSNNPTFLEVLEEFPSLRVPAAFLLSQLPILKPRYYSISSSQDHTPSEVHLTVAVVTYRTRDGQGPLHHGVCSTWINNLKPEDPVPCFVRSVSGFQLPEDPSQPCILIGPGTGIAPFRSFWQQRLHDSQHRGLKGGRMTLVFGCRHPEEDHLYQEEMQEMVRKGVLFQVHTGYSRLPGKPKVYVQDILQKELADEVFSVLHGEQGHLYVCGDVRMARDVATTLKKLVAAKLNLSEEQVEDYFFQLKSQKRYHEDIFGAVFSYGAKKGNTLEEPKGTRL
uniprot
proteins
ec_number
1.14.13.39
uniprot
proteins
function
FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8. {ECO:0000250|UniProtKB:P29477, ECO:0000250|UniProtKB:P35228}.
uniprot
proteins
mass_dalton
130628
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated; mediated by SPSB1, SPSB2 and SPSB4, leading to proteasomal degradation. {ECO:0000250|UniProtKB:P35228}.
uniprot
proteins
protein_family
NOS family
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
7513765
uniprot
proteins
pubmed
7516453
uniprot
proteins
pubmed
7519448
uniprot
proteins
pubmed
7540573
uniprot
proteins
pubmed
7680561
uniprot
proteins
pubmed
7682072
uniprot
proteins
pubmed
7693462
uniprot
proteins
pubmed
8913516
uniprot
proteins
pubmed
9535415
uniprot
proteins
pubmed
9851365
uniprot
proteins
sequence_length
1147
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P35228}. Note=Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization. {ECO:0000250|UniProtKB:P35228}.
uniprot
proteins