RGS4
entrez
5999
canonical
uniprot
P49798
canonical
ensembl
ENSG00000117152
resolver
ensp
ENSP00000356882
resolver
ensp
ENSP00000356884
resolver
ensp
ENSP00000356885
resolver
ensp
ENSP00000397181
resolver
genesymbol
RGS4
resolver
hgnc
HGNC:10000
resolver
uniprot
A7XA56
resolver
uniprot
A7XA58
resolver
uniprot
A7XA59
resolver
uniprot
A7YVV7
resolver
uniprot
B1APZ3
resolver
uniprot_entry
RGS4_HUMAN
resolver
uniprot_sec
A7XA56
resolver
uniprot_sec
A7XA58
resolver
uniprot_sec
A7XA59
resolver
uniprot_sec
A7YVV7
resolver
uniprot_sec
B1APZ3
resolver
amino_acid_sequence
MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNPSSCGAEKQKGAKSSADCASLVPQCA
uniprot
proteins
disease_involvement
DISEASE: Schizophrenia (SCZD) [MIM:181500]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269|PubMed:12023979, ECO:0000269|PubMed:14755443}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G protein.
uniprot
proteins
mass_dalton
23256
uniprot
proteins
post_translational_modification
PTM: Palmitoylated on Cys-2 and/or Cys-12. {ECO:0000269|PubMed:10608901}.; PTM: Phosphorylated by cyclic GMP-dependent protein kinase. {ECO:0000250}.
uniprot
proteins
pubmed
10608901
uniprot
proteins
pubmed
12023979
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14755443
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17707117
uniprot
proteins
pubmed
8602223
uniprot
proteins
pubmed
9748280
uniprot
proteins
sequence_length
205
uniprot
proteins