Hcrtr1
entrez
25593
canonical
uniprot
P56718
canonical
ensembl
ENSRNOG00000013838
resolver
ensembl
ENSRNOG00055023927
resolver
ensembl
ENSRNOG00060026227
resolver
ensembl
ENSRNOG00065025700
resolver
ensp
ENSRNOP00000018674
resolver
ensp
ENSRNOP00055033399
resolver
ensp
ENSRNOP00060037710
resolver
ensp
ENSRNOP00065036355
resolver
enst
ENSRNOT00000018674
resolver
enst
ENSRNOT00055041068
resolver
enst
ENSRNOT00060045418
resolver
enst
ENSRNOT00065044289
resolver
genesymbol
Hcrtr1
resolver
uniprot_entry
OX1R_RAT
resolver
amino_acid_sequence
MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that binds the neuropeptide orexin-A with high affinity, and orexin-B with lower affinity, two peptides derived from a common precursor, prepro-orexin. Its activity is mediated via a G(q)-protein-coupled pathway, which activates the phosphatidylinositol-calcium second messenger system in response to orexin-A binding. In addition to G(q)-mediated signaling, orexin-A stimulation also promotes beta-arrestin recruitment, leading to receptor internalization (By similarity). Plays a significant role in the regulation of food intake (PubMed:11102651, PubMed:11298806). {ECO:0000250|UniProtKB:O43613, ECO:0000269|PubMed:11102651, ECO:0000269|PubMed:11298806}.
uniprot
proteins
mass_dalton
46800
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11102651
uniprot
proteins
pubmed
11298806
uniprot
proteins
pubmed
9491897
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O43613}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O43613}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..67; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O43613"; TRANSMEM 83..105; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O43613"; TRANSMEM 120..140; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O43613"; TRANSMEM 161..182; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O43613"; TRANSMEM 214..235; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O43613"; TRANSMEM 299..321; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O43613"; TRANSMEM 337..360; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:O43613
uniprot
proteins