Rabac1
entrez
14470
canonical
uniprot
Q9Z0S9
canonical
ensembl
ENSMUSG00000003380
resolver
ensp
ENSMUSP00000076227
resolver
enst
ENSMUST00000076961
resolver
genesymbol
Rabac1
resolver
genesymbol_syn
Pra
resolver
genesymbol_syn
Pra1
resolver
genesymbol_syn
Praf1
resolver
uniprot
Q3TDB4
resolver
uniprot_entry
PRAF1_MOUSE
resolver
uniprot_sec
Q3TDB4
resolver
amino_acid_sequence
MAAQKDQQKDAEGEGLSATTLLPKLIPSGAGREWLERRRATIRPWGTFVDQQRFSRPRNVGELCQRLVRNVEYYQSNYVFVFLGLILYCVVTSPMLLVALAVFFGACYILYLRTLQSKLVLFGREVSPAHQYALAGGVSFPFFWLAGAGSAVFWVLGATLVLIGSHAAFHQMEPADGEELQMEPV
uniprot
proteins
function
FUNCTION: General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11335720}.
uniprot
proteins
mass_dalton
20619
uniprot
proteins
mutagenesis
MUTAGEN 176; /note="D->A: No effect."; /evidence="ECO:0000269|PubMed:14979871"; MUTAGEN 177; /note="G->A: No effect."; /evidence="ECO:0000269|PubMed:14979871"; MUTAGEN 178; /note="E->A: No effect."; /evidence="ECO:0000269|PubMed:14979871"; MUTAGEN 179; /note="E->A: No effect."; /evidence="ECO:0000269|PubMed:14979871"; MUTAGEN 185; /note="V->A,C,I,P: Partial retention in the endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:14979871"; MUTAGEN 185; /note="V->D,K: Retention in the endoplasmic reticulum; does not form homodimers."; /evidence="ECO:0000269|PubMed:14979871"; MUTAGEN 185; /note="V->M,N,Y,H,E,Q,T,S,L,W,F,G: Retention in the endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:14979871"; MUTAGEN 185; /note="V->R: No effect."; /evidence="ECO:0000269|PubMed:14979871"; MUTAGEN 185; /note="Missing: Partial retention in the endoplasmic reticulum; still forms homodimers."; /evidence="ECO:0000269|PubMed:14979871
uniprot
proteins
protein_family
PRA1 family
uniprot
proteins
pubmed
10964695
uniprot
proteins
pubmed
11335720
uniprot
proteins
pubmed
11535589
uniprot
proteins
pubmed
14979871
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7782346
uniprot
proteins
sequence_length
185
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O35394}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:O35394}. Golgi apparatus {ECO:0000250|UniProtKB:O35394}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:O35394}. Note=According to PubMed:11535589, it is an integral membrane protein, while other authors showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles. {ECO:0000250|UniProtKB:O35394}.
uniprot
proteins
transmembrane_region
TRANSMEM 79..94; /note="Helical"; TRANSMEM 95..112; /note="Helical"; TRANSMEM 132..148; /note="Helical"; TRANSMEM 149..165; /note="Helical
uniprot
proteins