Endov
entrez
338371
canonical
uniprot
Q8C9A2
canonical
ensembl
ENSMUSG00000039850
resolver
ensp
ENSMUSP00000101851
resolver
ensp
ENSMUSP00000132755
resolver
ensp
ENSMUSP00000224473
resolver
genesymbol
Endov
resolver
uniprot
B1ATE4
resolver
uniprot
Q3TCQ4
resolver
uniprot
Q8C3Y1
resolver
uniprot_entry
ENDOV_MOUSE
resolver
uniprot_sec
B1ATE4
resolver
uniprot_sec
Q3TCQ4
resolver
uniprot_sec
Q8C3Y1
resolver
amino_acid_sequence
MAHTAAERPPEETLSLWKGEQARLKARVVDRDTEAWQRDPSFSGLQKVGGVDVSFVKGDSVRACASLVVLSYPELKVVYEDSRMVGLKAPYVSGFLAFREVPFLVELVQRLQEKEPDLMPQVVLVDGNGVLHQRGFGVACHLGVLTELPCIGVAKKLLQVDGLENNALHKEKIVLLQAGGDTFPLIGSSGTVLGMALRSHDHSTKPLYVSVGHRISLEVAVRLTHHCCRFRIPEPIRQADIRSREYIRRTLGQLGVAPAQRKDRSQKEQRPNACPQGGPGALADQGRPPECDGRDSSSDRKAPEPGFQEQKDQQLEGTGHQEDSDLWPPSPAWVQSPP
uniprot
proteins
ec_number
3.1.26.-
uniprot
proteins
function
FUNCTION: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures. {ECO:0000250|UniProtKB:Q8N8Q3}.
uniprot
proteins
mass_dalton
37174
uniprot
proteins
mutagenesis
MUTAGEN 93; /note="S->P: No effect on activity."; /evidence="ECO:0000269|PubMed:12853604"; MUTAGEN 133; /note="Q->P: No effect on activity."; /evidence="ECO:0000269|PubMed:12853604
uniprot
proteins
protein_family
Endonuclease V family
uniprot
proteins
pubmed
12853604
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8N8Q3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8N8Q3}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q8N8Q3}. Note=Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with PABPC1. {ECO:0000250|UniProtKB:Q8N8Q3}.
uniprot
proteins