CANX
entrez
821
canonical
uniprot
P27824
canonical
ensembl
ENSG00000127022
resolver
ensembl
ENSG00000283777
resolver
ensp
ENSP00000247461
resolver
ensp
ENSP00000391646
resolver
ensp
ENSP00000424745
resolver
ensp
ENSP00000505013
resolver
ensp
ENSP00000505123
resolver
ensp
ENSP00000505129
resolver
ensp
ENSP00000505372
resolver
ensp
ENSP00000505470
resolver
ensp
ENSP00000506003
resolver
ensp
ENSP00000506051
resolver
ensp
ENSP00000506168
resolver
ensp
ENSP00000506591
resolver
ensp
ENSP00000573601
resolver
ensp
ENSP00000573602
resolver
ensp
ENSP00000573605
resolver
ensp
ENSP00000608118
resolver
ensp
ENSP00000608121
resolver
ensp
ENSP00000608128
resolver
ensp
ENSP00000608130
resolver
ensp
ENSP00000608132
resolver
enst
ENST00000680406
resolver
enst
ENST00000680894
resolver
enst
ENST00000680984
resolver
enst
ENST00000681076
resolver
enst
ENST00000681894
resolver
enst
ENST00000903542
resolver
enst
ENST00000903543
resolver
enst
ENST00000903546
resolver
enst
ENST00000938059
resolver
enst
ENST00000938069
resolver
enst
ENST00000938071
resolver
enst
ENST00000938073
resolver
genesymbol
CANX
resolver
hgnc
HGNC:1473
resolver
uniprot
A0A7P0T937
resolver
uniprot
A0A7P0TAE9
resolver
uniprot
A0A7P0TB65
resolver
uniprot
B2R5V8
resolver
uniprot
B4DGP8
resolver
uniprot
B4E2T8
resolver
uniprot
D3DWQ3
resolver
uniprot
D6R9K3
resolver
uniprot_entry
A0A7P0T937_HUMAN
resolver
uniprot_entry
A0A7P0TAE9_HUMAN
resolver
uniprot_entry
A0A7P0TB65_HUMAN
resolver
uniprot_entry
CALX_HUMAN
resolver
uniprot_sec
B2R5V8
resolver
uniprot_sec
B4DGP8
resolver
uniprot_sec
B4E2T8
resolver
uniprot_sec
D3DWQ3
resolver
uniprot_sec
D6R9K3
resolver
amino_acid_sequence
MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDWANDGWGLKKAADGAAEPGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKEEEEEKEEEKDKGDEEEEGEEKLEEKQKSDAEEDGGTVSQEEEDRKPKAEEDEILNRSPRNRKPRRE
uniprot
proteins
function
FUNCTION: Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
uniprot
proteins
mass_dalton
67568
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-564 by MAPK3/ERK1. Phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity). {ECO:0000250}.; PTM: Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins. {ECO:0000269|PubMed:22314232}.; PTM: Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4. {ECO:0000269|PubMed:21205830}.
uniprot
proteins
protein_family
Calreticulin family
uniprot
proteins
pubmed
12643545
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
1326756
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16361248
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20801878
uniprot
proteins
pubmed
21205830
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22314232
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23826168
uniprot
proteins
pubmed
24196833
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29765154
uniprot
proteins
pubmed
31735293
uniprot
proteins
pubmed
32783947
uniprot
proteins
pubmed
34338405
uniprot
proteins
pubmed
8055875
uniprot
proteins
pubmed
8136357
uniprot
proteins
pubmed
8486646
uniprot
proteins
pubmed
9188622
uniprot
proteins
pubmed
9420286
uniprot
proteins
sequence_length
592
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22314232}; Single-pass type I membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:P24643}; Single-pass type I membrane protein {ECO:0000255}. Melanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}; Single-pass type I membrane protein {ECO:0000255}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232). Localizes to endoplasmic reticulum mitochondria-associated membrane (MAMs) that connect the endoplasmic reticulum and the mitochondria (By similarity). {ECO:0000250|UniProtKB:P24643, ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:22314232}.
uniprot
proteins
transmembrane_region
TRANSMEM 482..502; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins