SULF1
entrez
23213
canonical
uniprot
Q8IWU6
canonical
ensembl
ENSG00000137573
resolver
ensp
ENSP00000260128
resolver
ensp
ENSP00000385704
resolver
ensp
ENSP00000390315
resolver
ensp
ENSP00000403040
resolver
ensp
ENSP00000480454
resolver
ensp
ENSP00000559179
resolver
ensp
ENSP00000559180
resolver
ensp
ENSP00000559181
resolver
ensp
ENSP00000559182
resolver
ensp
ENSP00000625472
resolver
ensp
ENSP00000675506
resolver
ensp
ENSP00000693102
resolver
ensp
ENSP00000754840
resolver
ensp
ENSP00000754841
resolver
ensp
ENSP00000781759
resolver
enst
ENST00000260128
resolver
enst
ENST00000402687
resolver
enst
ENST00000419716
resolver
enst
ENST00000458141
resolver
enst
ENST00000889122
resolver
genesymbol
SULF1
resolver
genesymbol_syn
KIAA1077
resolver
hgnc
HGNC:20391
resolver
uniprot
Q86YV8
resolver
uniprot
Q8NCA2
resolver
uniprot
Q9UPS5
resolver
uniprot_entry
SULF1_HUMAN
resolver
uniprot_sec
Q86YV8
resolver
uniprot_sec
Q8NCA2
resolver
uniprot_sec
Q9UPS5
resolver
amino_acid_sequence
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLRKKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPSDLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHTRQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLADSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNLREVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENNRRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQCNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG
uniprot
proteins
ec_number
3.1.6.1
uniprot
proteins
ec_number
3.1.6.14
uniprot
proteins
function
FUNCTION: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:12686563). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:12686563). Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (PubMed:12686563). {ECO:0000269|PubMed:12368295, ECO:0000269|PubMed:12686563}.
uniprot
proteins
mass_dalton
101027
uniprot
proteins
mutagenesis
MUTAGEN 87..88; /note="CC->AA: Loss of arylsulfatase activity and loss of ability to modulate apoptosis."; /evidence="ECO:0000269|PubMed:12368295, ECO:0000269|PubMed:12686563
uniprot
proteins
post_translational_modification
PTM: Processing by furin produces a secreted form. {ECO:0000269|PubMed:12368295}.; PTM: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. {ECO:0000250|UniProtKB:P15289}.
uniprot
proteins
protein_family
Sulfatase family
uniprot
proteins
pubmed
10470851
uniprot
proteins
pubmed
12368295
uniprot
proteins
pubmed
12686563
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
19159218
uniprot
proteins
sequence_length
871
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8VI60}. Golgi apparatus, Golgi stack {ECO:0000250|UniProtKB:Q8VI60}. Cell surface {ECO:0000269|PubMed:12368295, ECO:0000269|PubMed:12686563}.; SUBCELLULAR LOCATION: [Extracellular sulfatase Sulf-2 secreted form]: Secreted {ECO:0000269|PubMed:12368295}.
uniprot
proteins