Dct
entrez
13190
canonical
uniprot
P29812
canonical
ensembl
ENSMUSG00000022129
resolver
ensp
ENSMUSP00000022725
resolver
enst
ENSMUST00000022725
resolver
genesymbol
Dct
resolver
genesymbol_syn
Tyrp-2
resolver
genesymbol_syn
Tyrp2
resolver
uniprot
Q6NXI2
resolver
uniprot_entry
TYRP2_MOUSE
resolver
uniprot_sec
Q6NXI2
resolver
amino_acid_sequence
MGLVGWGLLLGCLGCGILLRARAQFPRVCMTLDGVLNKECCPPLGPEATNICGFLEGRGQCAEVQTDTRPWSGPYILRNQDDREQWPRKFFNRTCKCTGNFAGYNCGGCKFGWTGPDCNRKKPAILRRNIHSLTAQEREQFLGALDLAKKSIHPDYVITTQHWLGLLGPNGTQPQIANCSVYDFFVWLHYYSVRDTLLGPGRPYKAIDFSHQGPAFVTWHRYHLLWLERELQRLTGNESFALPYWNFATGKNECDVCTDELLGAARQDDPTLISRNSRFSTWEIVCDSLDDYNRRVTLCNGTYEGLLRRNKVGRNNEKLPTLKNVQDCLSLQKFDSPPFFQNSTFSFRNALEGFDKADGTLDSQVMNLHNLAHSFLNGTNALPHSAANDPVFVVLHSFTDAIFDEWLKRNNPSTDAWPQELAPIGHNRMYNMVPFFPPVTNEELFLTAEQLGYNYAVDLSEEEAPVWSTTLSVVIGILGAFVLLLGLLAFLQYRRLRKGYAPLMETGLSSKRYTEEA
uniprot
proteins
disease_involvement
DISEASE: Note=The slaty mutation in Tyrp2 leads to a decrease of DT activity and a consequent change in the pigmentation of the mice to a dark gray/brown eumelanin. The slaty-2j mutation has a similar phenotype, the slaty-lt (light) mutation has a more severe effect and is semidominant; its phenotype may be a result of the failure of the enzyme to be correctly targeted to its normal location on the inner face of the melanosomal membrane. {ECO:0000269|PubMed:1537334, ECO:0000269|PubMed:8530099}.
uniprot
proteins
ec_number
5.3.3.12
uniprot
proteins
function
FUNCTION: Plays a role in melanin biosynthesis (PubMed:33100333). Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:1537333, PubMed:1537334). {ECO:0000269|PubMed:1537333, ECO:0000269|PubMed:1537334, ECO:0000269|PubMed:33100333}.
uniprot
proteins
mass_dalton
58510
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="C->S: Mutant mice show hypopigmentation of the coat and have the retinal pigmented epithelium significantly less pigmented than wild-type retinas."; /evidence="ECO:0000269|PubMed:33100333"; MUTAGEN 61; /note="C->W: Mutant mice show hypopigmentation of the coat and have the retinal pigmented epithelium significantly less pigmented than wild-type retinas."; /evidence="ECO:0000269|PubMed:33100333
uniprot
proteins
pathway_participation
PATHWAY: Pigment biosynthesis; melanin biosynthesis.
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:1537333}.
uniprot
proteins
protein_family
Tyrosinase family
uniprot
proteins
pubmed
1537333
uniprot
proteins
pubmed
1537334
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26620560
uniprot
proteins
pubmed
33100333
uniprot
proteins
pubmed
7980602
uniprot
proteins
pubmed
8530099
uniprot
proteins
pubmed
8573077
uniprot
proteins
sequence_length
517
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000250|UniProtKB:P40126}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P40126}. Melanosome {ECO:0000269|PubMed:26620560}. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000269|PubMed:26620560}.
uniprot
proteins
transmembrane_region
TRANSMEM 473..491; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins