Elp1
entrez
140934
canonical
uniprot
Q8VHU4
canonical
ensembl
ENSRNOG00000016725
resolver
ensp
ENSRNOP00000022836
resolver
enst
ENSRNOT00000022836
resolver
genesymbol
Elp1
resolver
genesymbol_syn
Ikap
resolver
genesymbol_syn
Ikbkap
resolver
uniprot
F1LP76
resolver
uniprot_entry
ELP1_RAT
resolver
uniprot_entry
F1LP76_RAT
resolver
amino_acid_sequence
MRNLKLHQTLEFRDIQAPGKPQCFCLRAEQGTVLIGSERGLTEVDPVKKEVKTEISLVAEGFLPEDGSGCIVGIQDLLDQESVCVATASGDVIVCNVSTQQLECVGNVASGISVMSWSPDQELLLLATAQQTLIMMTRDYEVITEQQIHQDDFGEGKFITVGWGSKDTQFHGSEGRPITFPVQMHESALSWDDHRPQITWRGDGQFFAVSVVCSQTGARKIRVWNREFALQSTSESVPGLGPSLAWKPSGSLIASTQDKPNQQDVVFFEKNGLLHGYFTLPFLKDEVKVNDLLWNADSSVLAVWLEDLPKEGSSTLKSYVQLWTVGNYHWYLKQSLPFSTTGKNQIVSLLWDPVTPGRLHVLCQGWRYLCCDWHWTTDRSSGNSADDLANVAVIDGNKVLVTVFQRTVTPPPMCTYRLLIPHPVNQVMSSAHLGNDLAVLDASNQISVYKCDDKPDMDSTVKLGAVGGTGFKVPLRTPHLEKRYRIQFGNKEEEEDVSPLQFRFLTWIEGDAFLAISHSHSSPQSIIHHLTMAGSEGDEEQGQLNVSSSVTVDGVVIGLCCCSKTKSSAVQLADGQVLKYLWESPSSAVEPWKNSEGRPVRFARPCTQMEAAAIGGEECVLGLTDRCRFFINDTEVASNITSFAVCDDFLLVTTHSHTCQCFSLSGASLKMLQAGLCGSQVPSGEILRKVERGSRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKLMFKEAFECMRKLRINLNLIHDHNPKVFLENVETFIKQIDSVNHLNLFFTELKEEDVTKTMYPPPVTKSVQVSTNPDGKKVDLICDAMRVAMETINPRKFCLSILTSHVKKTTPELDIVLQKVHELQGKIPFVPESVSAEEALKYLLLLVDVNELFNHSLGTYDFDLVLMVAEKSQKDPKEYLPFLNTLKKMETNYQRFTIDKYLKRYEKALGHLSKCGPEYFTECLNLIKDKNLYKEALKLYRPDSPQYQAVSVAYGEHLVQELLYEPAGLVFARCGAHEKALEAFLACGSWQQALCMAAQLQMAKDKVAGLARTLAGKLVEQRKHSEAATVLEQYALDYEEAVLLLLEGSAWEEALRLVYKYDRVDIIETSVKPSILEAQKNYMDFLDSQTATFIRHKNRLKVVRELKSQRPRVHVDHEVAHGRETDLFSETSSIRSGSEMSGRYSHSNSRISARSSKNRRKAERKKHSLKEGSPLEGLALLEALSEVVQSIEKLKDEVHAILKVLFLFEFEEQARELQRAFESTLQLMGTALPDIWTLTGQQSSSTPVLGPSSTVNSIMASYQQQKTCVPVLDAWACLPPKIDQRSQWKLSLLE
uniprot
proteins
function
FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (By similarity). {ECO:0000250|UniProtKB:O95163, ECO:0000250|UniProtKB:Q06706, ECO:0000250|UniProtKB:Q7TT37}.
uniprot
proteins
mass_dalton
149171
uniprot
proteins
pathway_participation
PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. {ECO:0000250|UniProtKB:O95163}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
ELP1/IKA1 family
uniprot
proteins
pubmed
11722848
uniprot
proteins
sequence_length
1331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O95163}. Nucleus {ECO:0000250|UniProtKB:O95163}.
uniprot
proteins