BIK
entrez
638
canonical
uniprot
Q13323
canonical
ensembl
ENSG00000100290
resolver
ensp
ENSP00000216115
resolver
ensp
ENSP00000580724
resolver
ensp
ENSP00000580726
resolver
ensp
ENSP00000580729
resolver
ensp
ENSP00000626766
resolver
enst
ENST00000216115
resolver
enst
ENST00000910665
resolver
enst
ENST00000910667
resolver
enst
ENST00000910669
resolver
enst
ENST00000956707
resolver
genesymbol
BIK
resolver
genesymbol_syn
NBK
resolver
hgnc
HGNC:1051
resolver
uniprot
Q16582
resolver
uniprot
Q6FH93
resolver
uniprot_entry
BIK_HUMAN
resolver
uniprot_sec
Q16582
resolver
uniprot_sec
Q6FH93
resolver
amino_acid_sequence
MSEVRPLSRDILMETLLYEQLLEPPTMEVLGMTDSEEDLDPMEDFDSLECMEGSDALALRLACIGDEMDVSLRAPRLAQLSEVAMHSLGLAFIYDQTEDIRDVLRSFMDGFTTLKENIMRFWRSPNPGSWVSCEQVLLALLLLLALLLPLLSGGLHLLLK
uniprot
proteins
function
FUNCTION: Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. {ECO:0000269|PubMed:8521816}.
uniprot
proteins
mass_dalton
18016
uniprot
proteins
mutagenesis
MUTAGEN 153..154; /note="GG->FF: Inhibits RHBDL4/RHBDD1-induced cleavage."; /evidence="ECO:0000269|PubMed:18953687
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism. {ECO:0000269|PubMed:18953687}.; PTM: Ubiquitinated by the ECS(ASB11) complex in response to endoplasmic reticulum stress, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome. {ECO:0000269|PubMed:31387940}.
uniprot
proteins
pubmed
10500065
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18953687
uniprot
proteins
pubmed
23235460
uniprot
proteins
pubmed
23563182
uniprot
proteins
pubmed
31387940
uniprot
proteins
pubmed
7478623
uniprot
proteins
pubmed
8521816
uniprot
proteins
pubmed
8816500
uniprot
proteins
sequence_length
160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:8816500}; Single-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:O70337}; Single-pass membrane protein {ECO:0000255}. Note=Around the nuclear envelope, and in cytoplasmic membranes. {ECO:0000269|PubMed:8816500}.
uniprot
proteins
transmembrane_region
TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins