OOEP
entrez
441161
canonical
uniprot
A6NGQ2
canonical
ensembl
ENSG00000203907
resolver
ensp
ENSP00000359384
resolver
ensp
ENSP00000359388
resolver
ensp
ENSP00000769551
resolver
enst
ENST00000370359
resolver
enst
ENST00000370363
resolver
genesymbol
OOEP
resolver
genesymbol_syn
C6orf156
resolver
genesymbol_syn
KHDC2
resolver
genesymbol_syn
OEP19
resolver
hgnc
HGNC:21382
resolver
uniprot
A6NIN5
resolver
uniprot
A9UIB7
resolver
uniprot
F2Z364
resolver
uniprot_entry
F2Z364_HUMAN
resolver
uniprot_entry
OOEP_HUMAN
resolver
uniprot_sec
A6NIN5
resolver
uniprot_sec
A9UIB7
resolver
amino_acid_sequence
MVDDAGAAESQRGKQTPAHSLEQLRRLPLPPPQIRIRPWWFPVQELRDPLVFYLEAWLADELFGPDRAIIPEMEWTSQALLTVDIVDSGNLVEITVFGRPRVQNRVKSMLLCLAWFHREHRARAEKMKHLEKNLKAHASDPHSPQDPVA
uniprot
proteins
function
FUNCTION: Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development (By similarity). The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:41118754). They are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained state, regulating their availability for early embryonic development (By similarity). Cytoplasmic lattices also tightly control ubiquitination during the oocyte-to-embryo transition by trapping E3 ubiquitin-protein ligase UHRF1 in a compact autoinhibited conformation and maintaining SCF ubiquitin ligase complexes inactive (By similarity). As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity). Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes (By similarity). Thereby contributes to oocyte survival and the resumption and completion of meiosis (By similarity). {ECO:0000250|UniProtKB:Q9CWE6, ECO:0000269|PubMed:41118754}.
uniprot
proteins
mass_dalton
17170
uniprot
proteins
mutagenesis
MUTAGEN 109..116; /note="MLLCLAWF->DLLDDAWD: Impaired formation of the subcortical maternal complex (SCMC)."; /evidence="ECO:0000269|PubMed:39379527
uniprot
proteins
protein_family
KHDC1 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
17913455
uniprot
proteins
pubmed
25542835
uniprot
proteins
pubmed
26537248
uniprot
proteins
pubmed
35946397
uniprot
proteins
pubmed
37148315
uniprot
proteins
pubmed
39379527
uniprot
proteins
pubmed
41118754
uniprot
proteins
sequence_length
149
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25542835}. Nucleus {ECO:0000269|PubMed:25542835}. Note=Core component of cytoplasmic lattices in oocytes. In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions. Expression largely disappears in blastocysts. {ECO:0000250|UniProtKB:Q9CWE6}.
uniprot
proteins