Nlgn2
entrez
117096
canonical
uniprot
Q62888
canonical
ensembl
ENSRNOG00000015430
resolver
ensembl
ENSRNOG00055029231
resolver
ensembl
ENSRNOG00060031366
resolver
ensembl
ENSRNOG00065029740
resolver
ensp
ENSRNOP00000053713
resolver
ensp
ENSRNOP00000075845
resolver
genesymbol
Nlgn2
resolver
uniprot_entry
NLGN2_RAT
resolver
amino_acid_sequence
MWLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSTEAVECLRRKSSRELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRTPGPGTSGTRRPPPPATLPPESDIDLGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPTAGRELPPEEELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV
uniprot
proteins
function
FUNCTION: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion. {ECO:0000250|UniProtKB:Q69ZK9, ECO:0000269|PubMed:19755106, ECO:0000269|PubMed:22528485}.
uniprot
proteins
mass_dalton
90961
uniprot
proteins
mutagenesis
MUTAGEN 98; /note="N->A: N-glycosylation, localization to synapses, dendrites, and the cell membrane, as well as availability for trans-synaptic adhesion, are all impaired; when associated with A-136 and A-522."; /evidence="ECO:0000269|PubMed:37865312"; MUTAGEN 136; /note="N->A: N-glycosylation, localization to synapses, dendrites, and the cell membrane, as well as availability for trans-synaptic adhesion, are all impaired; when associated with A-98 and A-522."; /evidence="ECO:0000269|PubMed:37865312"; MUTAGEN 522; /note="N->A: N-glycosylation, localization to synapses, dendrites, and the cell membrane, as well as availability for trans-synaptic adhesion, are all impaired; when associated with A-98 and A-136."; /evidence="ECO:0000269|PubMed:37865312"; MUTAGEN 770; /note="Y->A: Abolishes interaction with GPHN."; /evidence="ECO:0000269|PubMed:19755106
uniprot
proteins
post_translational_modification
PTM: N-glycosylated, contains high-mannose, hybrid, complex and sialylated N-glycans. N-glycosylation is essential for localization to synapses, dendrites, and the cell membrane, and enhances its availability for trans-synaptic adhesion. O-glycosylated. {ECO:0000269|PubMed:37865312}.
uniprot
proteins
protein_family
Type-B carboxylesterase/lipase family
uniprot
proteins
pubmed
11329178
uniprot
proteins
pubmed
15620359
uniprot
proteins
pubmed
18334216
uniprot
proteins
pubmed
18434543
uniprot
proteins
pubmed
18755801
uniprot
proteins
pubmed
19755106
uniprot
proteins
pubmed
19859968
uniprot
proteins
pubmed
19914352
uniprot
proteins
pubmed
20624592
uniprot
proteins
pubmed
22528485
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23248271
uniprot
proteins
pubmed
23751499
uniprot
proteins
pubmed
28279354
uniprot
proteins
pubmed
29742426
uniprot
proteins
pubmed
37865312
uniprot
proteins
pubmed
8576240
uniprot
proteins
pubmed
9647694
uniprot
proteins
sequence_length
836
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37865312}; Single-pass type I membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000269|PubMed:29742426}; Single-pass type I membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000269|PubMed:19859968}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, dendritic spine {ECO:0000269|PubMed:18434543}. Cell projection, dendrite {ECO:0000269|PubMed:37865312}. Synapse {ECO:0000269|PubMed:37865312}. Note=Detected at presynaptic membranes in retina, and at postsynaptic membranes in brain. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes. Localizes to dendritic membrane. {ECO:0000269|PubMed:19859968, ECO:0000269|PubMed:29742426, ECO:0000269|PubMed:37865312}.
uniprot
proteins
transmembrane_region
TRANSMEM 679..699; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins