Efna1
entrez
94268
canonical
uniprot
P97553
canonical
ensembl
ENSRNOG00000020573
resolver
ensp
ENSRNOP00000027920
resolver
ensp
ENSRNOP00000082577
resolver
enst
ENSRNOT00000117150
resolver
genesymbol
Efna1
resolver
genesymbol_syn
Epgl1
resolver
genesymbol_syn
Lerk1
resolver
uniprot
A0A8I5ZUD2
resolver
uniprot
Q6NS29
resolver
uniprot_entry
A0A8I5ZUD2_RAT
resolver
uniprot_entry
EFNA1_RAT
resolver
uniprot_sec
Q6NS29
resolver
amino_acid_sequence
MEFLWAPLLGLCCSLAAADRHIVFWNSSNPKFREEDYTVHVQLNDYLDIICPHYEDDSVADAAMERYTLYMVEHQEYVTCEPQSKDQVRWKCNQPSAKHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIYHQETQCLKLKVTVNGKITHSPHAHANPQEKRLQADDPEVQVLHSIGHSAAPRLFPLVWAVLLLPLLLLQTQ
uniprot
proteins
function
FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Involved in angiogenesis, regulating vascular endothelial cell differentiation and migration through activation of EPHA2. Acts as a ligand for EPHA3, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development. May also contribute to dendritic spine morphogenesis. {ECO:0000250|UniProtKB:P52793}.
uniprot
proteins
mass_dalton
23763
uniprot
proteins
post_translational_modification
PTM: Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form. {ECO:0000250}.; PTM: N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization. {ECO:0000250|UniProtKB:P20827}.
uniprot
proteins
protein_family
Ephrin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7675446
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20827}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P20827}.; SUBCELLULAR LOCATION: [Ephrin-A1, secreted form]: Secreted {ECO:0000250|UniProtKB:P20827}.
uniprot
proteins