Ackr4
entrez
252837
canonical
uniprot
Q924I3
canonical
ensembl
ENSMUSG00000079355
resolver
ensp
ENSMUSP00000075507
resolver
ensp
ENSMUSP00000140792
resolver
ensp
ENSMUSP00000152036
resolver
ensp
ENSMUSP00000341109
resolver
enst
ENSMUST00000076147
resolver
enst
ENSMUST00000188000
resolver
enst
ENSMUST00000219146
resolver
genesymbol
Ackr4
resolver
genesymbol_syn
Ccr11
resolver
genesymbol_syn
Ccrl1
resolver
uniprot
B2RU75
resolver
uniprot
Q8C0M1
resolver
uniprot
Q8QZW9
resolver
uniprot_entry
ACKR4_MOUSE
resolver
uniprot_entry
B2RU75_MOUSE
resolver
uniprot_sec
Q8C0M1
resolver
uniprot_sec
Q8QZW9
resolver
amino_acid_sequence
MALELNQSAEYYYEENEMNYTHDYSQYEVICIKEEVRQFAKVFLPAFFTVAFVTGLAGNSVVVAIYAYYKKQRTKTDVYILNLAVADLLLLITLPFWAVNAVHGWILGKMMCKVTSALYTVNFVSGMQFLACISIDRYWAITKAPSQSGAGRPCWIICCCVWMAAILLSIPQLVFYTVNQNARCTPIFPHHLGTSLKASIQMLEIGIGFVVPFLIMGVCYASTARALIKMPNIKKSRPLRVLLAVVVVFIVTQLPYNVVKFCQAIDAIYLLITSCDMSKRMDVAIQVTESIALFHSCLNPILYVFMGASFKNYIMKVAKKYGSWRRQRQNVEEIPFDSEGPTEPTSSFTI
uniprot
proteins
function
FUNCTION: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus and inhibits spontaneous autoimmunity. {ECO:0000269|PubMed:11981810, ECO:0000269|PubMed:23152546}.
uniprot
proteins
mass_dalton
39531
uniprot
proteins
post_translational_modification
PTM: The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
Atypical chemokine receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11063828
uniprot
proteins
pubmed
11981810
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23152546
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000250}. Recycling endosome {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..62; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 78..99; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 200..220; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 290..310; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins