Slc25a13
entrez
50799
canonical
uniprot
Q9QXX4
canonical
ensembl
ENSMUSG00000015112
resolver
ensp
ENSMUSP00000015256
resolver
ensp
ENSMUSP00000139571
resolver
ensp
ENSMUSP00000216003
resolver
ensp
ENSMUSP00000216008
resolver
ensp
ENSMUSP00000345059
resolver
ensp
ENSMUSP00000345066
resolver
enst
ENSMUST00000015256
resolver
enst
ENSMUST00000188414
resolver
genesymbol
Slc25a13
resolver
genesymbol_syn
Agc2
resolver
uniprot
Q8C140
resolver
uniprot
Q9CZF6
resolver
uniprot
Q9DCF5
resolver
uniprot_entry
Q8C140_MOUSE
resolver
uniprot_entry
S2513_MOUSE
resolver
uniprot_sec
Q9CZF6
resolver
uniprot_sec
Q9DCF5
resolver
amino_acid_sequence
MAAAKVALTKRADPAELKAIFLKYASIEKNGEFFMSPHDFVTRYLNIFGESQPNPKTVELLSGVVDQTKDGLISFQEFVAFESVLCAPDALFMVAFQLFDKAGKGEVTFEDVKQIFGQTTIHQHIPFNWDSEFVQLHFGKERKRHLTYAEFTQFLLEIQLEHAKQAFVQRDNAKTGKVSAIDFRDIMVTIRPHVLTPFVEECLVAAAGGTRSHQVSFSYFNGFNSLLNNMELIRKIYSTLAGNRKDVEVTKEEFALAAQKFGQVTPMEVDILFQLADLYEPRGRMTLADIERIAPLEEGMLPFNLAEAQRQQKASGDAARPFLLQLAESAYRFGLGSIAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLLAEIFAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYNGVTDCFRKILREEGPKALWKGVAARVFRSSPQFGVTLLTYELLQRWFYVDFGGVKPVGSEPVPKSRITLPAPNPDHVGGYKLAVATFAGIENKFGLYLPLFKPSASTSKVTAGDS
uniprot
proteins
function
FUNCTION: Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange for L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation. Lacks transport activity towards gamma-aminobutyric acid (GABA). {ECO:0000250|UniProtKB:F1LZW6, ECO:0000250|UniProtKB:Q9UJS0}.
uniprot
proteins
mass_dalton
74467
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
10610724
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
676
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9UJS0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UJS0}.
uniprot
proteins
transmembrane_region
TRANSMEM 333..350; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O75746"; TRANSMEM 394..413; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O75746"; TRANSMEM 437..450; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O75746"; TRANSMEM 486..505; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O75746"; TRANSMEM 525..542; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O75746"; TRANSMEM 582..601; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O75746
uniprot
proteins