THUMPD3
entrez
25917
canonical
uniprot
Q9BV44
canonical
ensembl
ENSG00000134077
resolver
ensp
ENSP00000339532
resolver
ensp
ENSP00000395893
resolver
ensp
ENSP00000424064
resolver
ensp
ENSP00000544902
resolver
ensp
ENSP00000544903
resolver
ensp
ENSP00000544904
resolver
ensp
ENSP00000544905
resolver
ensp
ENSP00000544906
resolver
ensp
ENSP00000544908
resolver
ensp
ENSP00000544909
resolver
ensp
ENSP00000544910
resolver
ensp
ENSP00000582153
resolver
ensp
ENSP00000582154
resolver
ensp
ENSP00000582155
resolver
ensp
ENSP00000582156
resolver
ensp
ENSP00000582158
resolver
ensp
ENSP00000621613
resolver
ensp
ENSP00000621614
resolver
ensp
ENSP00000621615
resolver
ensp
ENSP00000621616
resolver
ensp
ENSP00000621619
resolver
ensp
ENSP00000621621
resolver
ensp
ENSP00000621622
resolver
ensp
ENSP00000621623
resolver
ensp
ENSP00000621624
resolver
ensp
ENSP00000621626
resolver
ensp
ENSP00000716222
resolver
ensp
ENSP00000716223
resolver
ensp
ENSP00000716225
resolver
ensp
ENSP00000736417
resolver
enst
ENST00000345094
resolver
enst
ENST00000452837
resolver
enst
ENST00000515662
resolver
enst
ENST00000874843
resolver
enst
ENST00000874844
resolver
enst
ENST00000874845
resolver
enst
ENST00000874846
resolver
enst
ENST00000874847
resolver
enst
ENST00000874849
resolver
enst
ENST00000874850
resolver
enst
ENST00000874851
resolver
enst
ENST00000912094
resolver
enst
ENST00000912095
resolver
enst
ENST00000912096
resolver
enst
ENST00000912097
resolver
enst
ENST00000912099
resolver
enst
ENST00000951554
resolver
enst
ENST00000951555
resolver
enst
ENST00000951556
resolver
enst
ENST00000951557
resolver
enst
ENST00000951560
resolver
enst
ENST00000951562
resolver
enst
ENST00000951563
resolver
enst
ENST00000951564
resolver
enst
ENST00000951565
resolver
enst
ENST00000951567
resolver
genesymbol
THUMPD3
resolver
hgnc
HGNC:24493
resolver
uniprot
Q9H8V6
resolver
uniprot
Q9NVC1
resolver
uniprot
Q9UFS3
resolver
uniprot_entry
THUM3_HUMAN
resolver
uniprot_sec
Q9H8V6
resolver
uniprot_sec
Q9NVC1
resolver
uniprot_sec
Q9UFS3
resolver
amino_acid_sequence
MCDIEEATNQLLDVNLHENQKSVQVTESDLGSESELLVTIGATVPTGFEQTAADEVREKLGSSCKISRDRGKIYFVISVESLAQVHCLRSVDNLFVVVQEFQDYQFKQTKEEVLKDFEDLAGKLPWSNPLKVWKINASFKKKKAKRKKINQNSSKEKINNGQEVKIDQRNVKKEFTSHALDSHILDYYENPAIKEDVSTLIGDDLASCKDETDESSKEETEPQVLKFRVTCNRAGEKHCFTSNEAARDFGGAVQDYFKWKADMTNFDVEVLLNIHDNEVIVGIALTEESLHRRNITHFGPTTLRSTLAYGMLRLCDPLPYDIIVDPMCGTGAIPIEGATEWSDCFHIAGDNNPLAVNRAANNIASLLTKSQIKEGKPSWGLPIDAVQWDICNLPLRTGSVDIIVTDLPFGKRMGSKKRNWNLYPACLREMSRVCTPTTGRAVLLTQDTKCFTKALSGMRHVWRKVDTVWVNVGGLRAAVYVLIRTPQAFVHPSEQDGERGTLWQCKE
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.256
uniprot
proteins
function
FUNCTION: Catalytic subunit of the THUMPD3-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 6 (m2G6) in tRNAs (PubMed:34669960, PubMed:37283053). This is one of the major tRNA (guanine-N(2))-methyltransferases (PubMed:37283053). Also catalyzes the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 7 of tRNA(Trp) (PubMed:34669960). {ECO:0000269|PubMed:34669960, ECO:0000269|PubMed:37283053}.
uniprot
proteins
mass_dalton
57003
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
34669960
uniprot
proteins
pubmed
34948388
uniprot
proteins
pubmed
37283053
uniprot
proteins
sequence_length
507
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34669960, ECO:0000269|PubMed:34948388}.
uniprot
proteins