Bcar1
entrez
12927
canonical
uniprot
Q61140
canonical
ensembl
ENSMUSG00000031955
resolver
ensp
ENSMUSP00000129584
resolver
ensp
ENSMUSP00000148364
resolver
genesymbol
Bcar1
resolver
genesymbol_syn
Cas
resolver
genesymbol_syn
Crkas
resolver
uniprot
Q3TJP4
resolver
uniprot
Q60869
resolver
uniprot
Q6PFF9
resolver
uniprot_entry
BCAR1_MOUSE
resolver
uniprot_entry
Q3TJP4_MOUSE
resolver
uniprot_sec
Q60869
resolver
uniprot_sec
Q6PFF9
resolver
amino_acid_sequence
MTVPNVLAKALYDNVAESPDELSFRKGDIMTVLERDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKPVGPGPGPPATPPQPQPSLPQGVHAPVPPASQYSPMLPTAYQPQSDNVYLVPTPSKTQQGLYQAPGPNPQFQSPPAKQTSTFSKQTPHHSFPSPATDLYQVPPGPGSPAQDIYQVPPSAGIGHDIYQVPPSLDTRGWEGTKPPAKVVVPTRVGQGYVYEAAQTEQDEYDTPRHLLAPGPQDIYDVPPVRGLLPNQYGQEVYDTPPMAVKGPNGRDPLLDVYDVPPSVEKGLLSSSHHSVYDVPPSVSKDVPDGPLLREETYDVPPAFAKPKPFDPTRHPLILAAPPPDSPAAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGSVVDDGVYAVPPPAEREAPTDGKRLSASSTGSTRSSQSASSLEVVVPGREPLELEVAVESLARLQQGVSTTVAHLLDLVGSASGPGGWRGTSEPQEPPAQDLKAAVAAVHGAVHELLEFARGAVSNATHTSDRTLHAKLSRQLQKMEDVYQTLVVHGQVLDSGRGSPGFTPEDLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKAPGPGPEGSSSLHPNPTDKASSIQSRPLPSPPKFTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLERGNIMRQGKGQLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLVPGRTGGLGPSDRQLLLFYLEQCEANLTTLTDAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVDRVKELGHSTQQFRRVLGQLAAA
uniprot
proteins
function
FUNCTION: Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (By similarity). Implicated in induction of cell migration and cell branching (PubMed:25499443). Involved in the BCAR3-mediated inhibition of TGFB signaling (PubMed:25499443). {ECO:0000250|UniProtKB:P56945, ECO:0000269|PubMed:25499443}.
uniprot
proteins
mass_dalton
94285
uniprot
proteins
post_translational_modification
PTM: PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix (By similarity). {ECO:0000250}.; PTM: Dephosphorylated by PTPN14 at Tyr-132. {ECO:0000250}.; PTM: Phosphorylated by SRC kinase in a EDN1- and PTK2B-mediated manner; phosphorylation strengthens its interaction with BCAR3 as part of the PTK2B/BCAR1/BCAR3/RAP1 signaling pathway. {ECO:0000250|UniProtKB:P56945}.
uniprot
proteins
protein_family
CAS family
uniprot
proteins
pubmed
10438950
uniprot
proteins
pubmed
10692442
uniprot
proteins
pubmed
10739664
uniprot
proteins
pubmed
10896938
uniprot
proteins
pubmed
12486027
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17174122
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19365570
uniprot
proteins
pubmed
20881139
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22801373
uniprot
proteins
pubmed
25499443
uniprot
proteins
pubmed
7479864
uniprot
proteins
sequence_length
874
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:22801373}. Cytoplasm {ECO:0000269|PubMed:22801373}. Cell projection, axon {ECO:0000269|PubMed:20881139}. Note=Unphosphorylated form localizes in the cytoplasm (PubMed:22801373). Localizes to focal adhesion sites following integrin engagement (PubMed:22801373). {ECO:0000269|PubMed:22801373}.
uniprot
proteins