Fhl2
entrez
14200
canonical
uniprot
O70433
canonical
ensembl
ENSMUSG00000008136
resolver
ensp
ENSMUSP00000008280
resolver
ensp
ENSMUSP00000141170
resolver
ensp
ENSMUSP00000222900
resolver
enst
ENSMUST00000008280
resolver
enst
ENSMUST00000185893
resolver
genesymbol
Fhl2
resolver
uniprot
P97448
resolver
uniprot
Q543D7
resolver
uniprot_entry
FHL2_MOUSE
resolver
uniprot_entry
Q543D7_MOUSE
resolver
uniprot_sec
P97448
resolver
amino_acid_sequence
MTERFDCHHCNESLYGKKYILKEENPHCVACFEELYANTCEECGTPIGCDCKDLSYKDRHWHEGCFHCSRCGSSLVDKPFAAKEEQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFTCQRCQQPIGTKSFIPKENQNFCVPCYEKQYALQCVQCKKPITTGGVTYREQPWHKECFVCTACKKQLSGQRFTARDEFPYCLTCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI
uniprot
proteins
function
FUNCTION: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity). Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:22851699). {ECO:0000250|UniProtKB:Q14192, ECO:0000269|PubMed:22851699}.
uniprot
proteins
mass_dalton
32073
uniprot
proteins
pubmed
10049693
uniprot
proteins
pubmed
10906474
uniprot
proteins
pubmed
20013826
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22851699
uniprot
proteins
sequence_length
279
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14192}. Nucleus {ECO:0000269|PubMed:20013826}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:22851699}.
uniprot
proteins