Trim16
entrez
94092
canonical
uniprot
Q99PP9
canonical
ensembl
ENSMUSG00000047821
resolver
ensp
ENSMUSP00000055542
resolver
ensp
ENSMUSP00000104343
resolver
enst
ENSMUST00000055006
resolver
genesymbol
Trim16
resolver
genesymbol_syn
Ebbp
resolver
uniprot
Q5SVT2
resolver
uniprot
Q7TPY6
resolver
uniprot
Q8C332
resolver
uniprot
Q8C6V0
resolver
uniprot_entry
Q5SVT2_MOUSE
resolver
uniprot_entry
TRI16_MOUSE
resolver
uniprot_sec
Q7TPY6
resolver
uniprot_sec
Q8C332
resolver
uniprot_sec
Q8C6V0
resolver
amino_acid_sequence
MAELDLIAPGPLTGVTAHPLAPLGPDPVSAIPVEKEDADPLSKSGEETQEQGHDPAELGAPGEEDQILCDFCLGASRVRAVKSCLTCMVNYCEEHLRPHQENSKLHSHQLTEPAKDQDLRTCPAHHSPLVSFCHTHQQCICQECGEGEHRGDSTVSLDAARRNKEVDLRCMQLDLEQKLKLNENAIARLQANHKSVLVSVSEVKVVAEEKFGELLAAVRKAQADVMVFLEEKEQAALNQVNSIKTHLEHRSLEMEKSKQELERLAAISNTVLFLEEYCKLKKTEDTASPSIYIGLKDKLSGIRKVITDSTLNLIQLLESYKEKLQEFSREEEYDIRTQVSAIVQRKYRTSKPEPRTRDEFLQYACDITFDPDTAHRYLRLQEDNRKVTNTTPWEHPYPDLPSRFLHWRQVLSQQSLYLHRYYFEVELSGGGTYVGLTCKGIDRKGEERNSCISGNSFSWSIHWNGKEFTAWHSDTETPLKVSPFRRLGIYVNFPGGILSFYGVEYDAMTLIHKFDCKFSEPVYAAFWLSKKENAIRIVDLGEEPEKPAGSSVEAAP
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages (By similarity). Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2 (By similarity). Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000250|UniProtKB:O95361}.
uniprot
proteins
mass_dalton
62943
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ULK1. {ECO:0000250|UniProtKB:O95361}.; PTM: Auto-ubiquitinates via its B-Boxes. {ECO:0000250|UniProtKB:O95361}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
11919186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
556
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O95361}.
uniprot
proteins