Osbpl10
entrez
74486
canonical
uniprot
S4R1M9
canonical
ensembl
ENSMUSG00000040875
resolver
ensp
ENSMUSP00000038013
resolver
ensp
ENSMUSP00000138287
resolver
ensp
ENSMUSP00000138552
resolver
ensp
ENSMUSP00000279155
resolver
enst
ENSMUST00000046627
resolver
enst
ENSMUST00000182384
resolver
enst
ENSMUST00000183104
resolver
genesymbol
Osbpl10
resolver
genesymbol_syn
Orp10
resolver
uniprot
A0A0R4J0F9
resolver
uniprot
Q8R2T7
resolver
uniprot
S4R296
resolver
uniprot_entry
A0A0R4J0F9_MOUSE
resolver
uniprot_entry
OSB10_MOUSE
resolver
uniprot_entry
S4R296_MOUSE
resolver
uniprot_sec
Q8R2T7
resolver
amino_acid_sequence
MERAAQSTDGGGGGGSNSSSRSSSRATSAGSSPSCSLAGRGVASRSGAAGLGGGGSRSSPGSVAASPSGGGGRRREPALEGVLSKYTNLLQGWQSRYFVLDFEAGLLQYFVNEQSKHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMYKLRAADSKEKQLWVTQLRACAKYHMEMSSKTTPGSRSRSLTLLPHGTPSSASPCSQRHLSTGAPGVVSVTRHKSPAAARRAKSQYSGQLHEVREMMNQVEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLSLLQQSVRQAAPPSHKPGASETILGWHGPTSHSTDQLKNGTLGSLPSASANITWAILPNSAEEEHNSQPEPEPDSGPELVLSEEEQSDNEDKGEVEPGAMEDQRSVILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVISFVEYYLTAFHEGRKGTLAKKPYNPIIGETFHCSWEVPKDRVKSKWTSPHPPISAHEHPMADDPSKSYKLRFVAEQVSHHPPISCFYCECKEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLDHGEEYVFTLPSAYARSILTVPWVELGGKVNISCAKTGYSATVTFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTYSNGETKVIDTTTLPVYPKKLRPLEKQGPMESRNLWQEVTHYLRLGDIDAATEQKRRLEERQRVEERKRETLRTPWRPKYFIPEGDGWVYFNPLWKTH
uniprot
proteins
function
FUNCTION: Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P. Plays a role in negative regulation of lipid biosynthesis. Interacts with OSBPL9 to function as lipid transfer proteins. Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25-hydroxycholesterol. Binds phosphatidylserine. {ECO:0000250|UniProtKB:Q9BXB5}.
uniprot
proteins
mass_dalton
83856
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
766
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9BXB5}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q9BXB5}. Note=Associates with microtubules. {ECO:0000250|UniProtKB:Q9BXB5}.
uniprot
proteins