Lpcat1
entrez
361467
canonical
uniprot
Q1HAQ0
canonical
ensembl
ENSRNOG00000017930
resolver
ensembl
ENSRNOG00055003029
resolver
ensembl
ENSRNOG00060025843
resolver
ensembl
ENSRNOG00065018838
resolver
ensp
ENSRNOP00000024111
resolver
ensp
ENSRNOP00055003491
resolver
ensp
ENSRNOP00060037119
resolver
ensp
ENSRNOP00065025237
resolver
enst
ENSRNOT00055004720
resolver
enst
ENSRNOT00060044768
resolver
enst
ENSRNOT00065031647
resolver
genesymbol
Lpcat1
resolver
genesymbol_syn
Aytl2
resolver
uniprot_entry
PCAT1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activity is stimulated by Mg(2+) or Mn(2+). {ECO:0000269|PubMed:16864775}.
uniprot
proteins
amino_acid_sequence
MRLRGRGPRAAPSSSSGAGDARRLAPPGRNPFVHELRLSALQKAQVAFMTLTLFPIRLLFAAFMMLLAWPFALVASLGPPDKEPEQPLALWRKVVDFLLKAIMRTMWFAGGFHRVAVKGRQALPTEAAILTLAPHSSYFDAIPVTMTMSSIVMKAESRDIPIWGTLIRYIRPVFVSRSDQDSRRKTVEEIKRRAQSNGKWPQIMIFPEGTCTNRTCLITFKPGAFIPGVPVQPVVLRYPNKLDTITWTWQGPGALKILWLTLCQFQNQVEIEFLPVYCPSEEEKRNPALYASNVRRVMAKALGVSVTDYTFEDCQLALAEGQLRLPADTCLLEFARLVRGLGLKPENLEKDLDKYSESARMKRGEKIRLPEFAAYLEVPVSDALEDMFSLFDESGGGEIDLREYVVALSVVCRPSQTLATIQLAFKMYGSPEDGSIDEADLSCILKTALGISELTVTDLFQAIDQEERGRITFDDFCGFAEMYPDFAEDYLYPDQTHSDSCAQTPPAPTPNGFCIDFSPEHSDFGRKNSCKKVD
uniprot
proteins
ec_number
2.3.1.23
uniprot
proteins
ec_number
2.3.1.25
uniprot
proteins
ec_number
2.3.1.51
uniprot
proteins
ec_number
2.3.1.67
uniprot
proteins
function
FUNCTION: Exhibits acyltransferase activity (PubMed:16864775). Exhibits acetyltransferase activity (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:16864775). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:16864775). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (PubMed:16864775). Involved in the regulation of lipid droplet number and size (By similarity). {ECO:0000250|UniProtKB:Q3TFD2, ECO:0000250|UniProtKB:Q8NF37, ECO:0000269|PubMed:16864775}.
uniprot
proteins
mass_dalton
59762
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; phospholipid metabolism.
uniprot
proteins
protein_family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16704971
uniprot
proteins
pubmed
16864775
uniprot
proteins
sequence_length
534
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8NF37}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8NF37}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q3TFD2}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8NF37}. Cell membrane {ECO:0000250|UniProtKB:Q8NF37}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8NF37}. Lipid droplet {ECO:0000250|UniProtKB:Q8NF37}. Note=May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm. {ECO:0000250|UniProtKB:Q8NF37}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..78; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins