Adam17
entrez
11491
canonical
uniprot
Q9Z0F8
canonical
ensembl
ENSMUSG00000052593
resolver
ensp
ENSMUSP00000067953
resolver
ensp
ENSMUSP00000099087
resolver
enst
ENSMUST00000101551
resolver
genesymbol
Adam17
resolver
genesymbol_syn
Tace
resolver
uniprot
E9PXU2
resolver
uniprot
O88726
resolver
uniprot
Q505A7
resolver
uniprot
Q9R1U4
resolver
uniprot
Q9Z0K3
resolver
uniprot_entry
ADA17_MOUSE
resolver
uniprot_entry
E9PXU2_MOUSE
resolver
uniprot_sec
O88726
resolver
uniprot_sec
Q505A7
resolver
uniprot_sec
Q9R1U4
resolver
uniprot_sec
Q9Z0K3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by metalloproteinase inhibitor 3 (TIMP-3), but not by TIMP-1, TIMP-2 and TIMP-4. {ECO:0000269|PubMed:9755855}.
uniprot
proteins
amino_acid_sequence
MRRRLLILTTLVPFVLAPRPPEEAGSGSHPRLEKLDSLLSDYDILSLANIQQHSIRKRDLQSATHLETLLTFSALKRHFKLYLTSSTERFSQNLRVVVVDGKEESEYSVKWQNFFSGHVVGEPDSRVLAHIGDDDVTVRINTDGAEYNVEPLWRFVNDTKDKRMLVYKSEDIKDFSRLQSPKVCGYLNADSEELLPKGLIDREPSEEFVRRVKRRAEPNPLKNTCKLLVVADHRFYKYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGVQIEQIRILKSPQEVKPGERHFNMAKSFPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYNPTVKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKPGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGDAEDDTVCLDLGKCKAGKCIPFCKREQELESCACVDTDNSCKVCCRNLSGPCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHHSNIEMLSSMDSASVRIIKPFPAPQTPGRLQALQPAAMMPPVPAAPKLDHQRMDTIQEDPSTDSHADDDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQSRVDSKETEC
uniprot
proteins
ec_number
3.4.24.86
uniprot
proteins
function
FUNCTION: Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2 (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:10799547, PubMed:11108241). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT) (PubMed:10882063). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (PubMed:12907434). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (PubMed:17245433). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (By similarity). Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. {ECO:0000250|UniProtKB:P78536, ECO:0000269|PubMed:10799547, ECO:0000269|PubMed:10882063, ECO:0000269|PubMed:11108241, ECO:0000269|PubMed:12907434, ECO:0000269|PubMed:17245433}.; FUNCTION: Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity (PubMed:10799547, PubMed:10882063). Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:10799547, PubMed:11108241). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:10882063). Plays a role in the proteolytic processing of ACE2 (By similarity). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (PubMed:12907434). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (PubMed:17245433). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R. Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (By similarity). {ECO:0000250|UniProtKB:P78536, ECO:0000269|PubMed:10799547, ECO:0000269|PubMed:10882063, ECO:0000269|PubMed:11108241, ECO:0000269|PubMed:12907434, ECO:0000269|PubMed:17245433}.
uniprot
proteins
mass_dalton
93056
uniprot
proteins
mutagenesis
MUTAGEN 647; /note="D->N: Homozygous mice show impaired hair regeneration and abnormal hair characteristics including wavy vibrissae and a thin wavy coat."; /evidence="ECO:0000269|PubMed:38771644
uniprot
proteins
post_translational_modification
PTM: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.; PTM: Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-822 but decreases phosphorylation of Ser-794. Phosphorylation at Thr-735 by MAPK14 is required for ADAM17-mediated ectodomain shedding (By similarity). {ECO:0000250|UniProtKB:P78536}.; PTM: Ubiquitinated by the E3 ligase TRIM47 leading to proteasomal degradation. {ECO:0000250|UniProtKB:P78536}.
uniprot
proteins
pubmed
10375622
uniprot
proteins
pubmed
10433800
uniprot
proteins
pubmed
10799547
uniprot
proteins
pubmed
10882063
uniprot
proteins
pubmed
11108241
uniprot
proteins
pubmed
12907434
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17245433
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
38771644
uniprot
proteins
pubmed
9755855
uniprot
proteins
sequence_length
827
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Long]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Short]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 672..692; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins