Hexb
entrez
15212
canonical
uniprot
P20060
canonical
ensembl
ENSMUSG00000021665
resolver
ensp
ENSMUSP00000022169
resolver
enst
ENSMUST00000022169
resolver
genesymbol
Hexb
resolver
uniprot
Q3TXR9
resolver
uniprot_entry
HEXB_MOUSE
resolver
uniprot_entry
Q3TXR9_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Addition of GM2A stimulates the hydrolysis of sulfated glycosphingolipid SM2 and the ganglioside GM2. {ECO:0000250|UniProtKB:P07686}.
uniprot
proteins
amino_acid_sequence
MPQSPRSAPGLLLLQALVSLVSLALVAPARLQPALWPFPRSVQMFPRLLYISAEDFSIDHSPNSTAGPSCSLLQEAFRRYYNYVFGFYKRHHGPARFRAEPQLQKLLVSITLESECESFPSLSSDETYSLLVQEPVAVLKANSVWGALRGLETFSQLVYQDSFGTFTINESSIADSPRFPHRGILIDTSRHFLPVKTILKTLDAMAFNKFNVLHWHIVDDQSFPYQSTTFPELSNKGSYSLSHVYTPNDVRMVLEYARLRGIRVIPEFDTPGHTQSWGKGQKNLLTPCYNQKTKTQVFGPVDPTVNTTYAFFNTFFKEISSVFPDQFIHLGGDEVEFQCWASNPNIQGFMKRKGFGSDFRRLESFYIKKILEIISSLKKNSIVWQEVFDDKVELQPGTVVEVWKSEHYSYELKQVTGSGFPAILSAPWYLDLISYGQDWKNYYKVEPLNFEGSEKQKQLVIGGEACLWGEFVDATNLTPRLWPRASAVGERLWSPKTVTDLENAYKRLAVHRCRMVSRGIAAQPLYTGYCNYENKI
uniprot
proteins
ec_number
3.2.1.52
uniprot
proteins
function
FUNCTION: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (PubMed:8253842). {ECO:0000250|UniProtKB:P07686, ECO:0000269|PubMed:8253842}.
uniprot
proteins
mass_dalton
61116
uniprot
proteins
protein_family
Glycosyl hydrolase 20 family
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2971567
uniprot
proteins
pubmed
7918686
uniprot
proteins
pubmed
7959736
uniprot
proteins
pubmed
8253842
uniprot
proteins
sequence_length
536
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:P07686}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000269|PubMed:8253842}. Note=In oocytes, the enzyme is released from cortical granules after fertilization. {ECO:0000269|PubMed:8253842}.
uniprot
proteins