Il31ra
entrez
218624
canonical
uniprot
Q8K5B1
canonical
ensembl
ENSMUSG00000050377
resolver
ensp
ENSMUSP00000058045
resolver
ensp
ENSMUSP00000153382
resolver
enst
ENSMUST00000224510
resolver
genesymbol
Il31ra
resolver
genesymbol_syn
Glmr
resolver
uniprot
A0A286YDE2
resolver
uniprot
E9QQ31
resolver
uniprot
Q6EAL6
resolver
uniprot
Q6EAL7
resolver
uniprot
Q6NZF0
resolver
uniprot
Q8BSU3
resolver
uniprot
Q8R501
resolver
uniprot_entry
A0A286YDE2_MOUSE
resolver
uniprot_entry
IL31R_MOUSE
resolver
uniprot_sec
E9QQ31
resolver
uniprot_sec
Q6EAL6
resolver
uniprot_sec
Q6EAL7
resolver
uniprot_sec
Q6NZF0
resolver
uniprot_sec
Q8BSU3
resolver
uniprot_sec
Q8R501
resolver
amino_acid_sequence
MWTLALWAFSFLCKFSLAVLPTKPENISCVFYFDRNLTCTWRPEKETNDTSYIVTLTYSYGKSNYSDNATEASYSFPRSCAMPPDICSVEVQAQNGDGKVKSDITYWHLISIAKTEPPIILSVNPICNRMFQIQWKPREKTRGFPLVCMLRFRTVNSSHWTEVNFENCKQVCNLTGLQAFTEYVLALRFRFNDSRYWSKWSKEETRVTMEEVPHVLDLWRILEPADMNGDRKVRLLWKKARGAPVLEKTFGYHIQYFAENSTNLTEINNITTQQYELLLMSQAHSVSVTSFNSLGKSQEAILRIPDVHEKTFQYIKSMKAYIAEPLLVVNWQSSIPAVDTWIVEWLPEAAMSKFPALSWESVSQVTNWTIEQDKLKPFTCYNISVYPVLGHRVGEPYSIQAYAKEGTPLKGPETRVENIGLRTATITWKEIPKSARNGFINNYTVFYQAEGGKELSKTVNSHALQCDLESLTRRTSYTVWVMASTRAGGTNGVRINFKTLSISVFEIVLLTSLVGGGLLLLSIKTVTFGLRKPNRLTPLCCPDVPNPAESSLATWLGDGFKKSNMKETGNSGDTEDVVLKPCPVPADLIDKLVVNFENFLEVVLTEEAGKGQASILGGEANEYVTSPSRPDGPPGKSFKEPSVLTEVASEDSHSTCSRMADEAYSELARQPSSSCQSPGLSPPREDQAQNPYLKNSVTTREFLVHENIPEHSKGEV
uniprot
proteins
function
FUNCTION: Functions as a membrane-bound signal-transducing subunit of the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) which binds IL31 (By similarity). Functionally, IL31 signaling via OSMR/IL31RA is particularly important in skin immunity (PubMed:15184896). Mechanistically, ligand binding induces heterodimerization with OSMR, activating JAK1 and JAK2 (and to a lesser extent TYK2) associated with the intracellular domains of IL31RA and OSMR. These kinases phosphorylate tyrosine residues on IL31RA and OSMR, creating docking sites for STAT1, STAT3, and STAT5B, which are then phosphorylated and activated. In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (By similarity). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (PubMed:24373353). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (PubMed:17379091). {ECO:0000250|UniProtKB:Q8NI17, ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:17379091, ECO:0000269|PubMed:24373353}.
uniprot
proteins
mass_dalton
80580
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q8NI17}.
uniprot
proteins
protein_family
Type 2 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
11877449
uniprot
proteins
pubmed
15184896
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16926070
uniprot
proteins
pubmed
17379091
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24373353
uniprot
proteins
pubmed
25381841
uniprot
proteins
pubmed
25847241
uniprot
proteins
sequence_length
716
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25847241}; Single-pass type I membrane protein {ECO:0000305}. Presynaptic cell membrane {ECO:0000269|PubMed:25381841}. Cell projection, axon {ECO:0000269|PubMed:25381841}.
uniprot
proteins
transmembrane_region
TRANSMEM 500..520; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins