Fbxl17
entrez
50758
canonical
uniprot
Q9QZN1
canonical
ensembl
ENSMUSG00000023965
resolver
ensp
ENSMUSP00000024761
resolver
ensp
ENSMUSP00000275039
resolver
ensp
ENSMUSP00000330546
resolver
genesymbol
Fbxl17
resolver
genesymbol_syn
Fbl17
resolver
genesymbol_syn
Fbx13
resolver
genesymbol_syn
Fbxo13
resolver
uniprot
B2RRC1
resolver
uniprot
Q8BTC3
resolver
uniprot_entry
FXL17_MOUSE
resolver
uniprot_sec
B2RRC1
resolver
uniprot_sec
Q8BTC3
resolver
amino_acid_sequence
MGHLLSKEPRNRPSQKRPRCCSWCRRRRPLLRLPRRALAKASPQPAAPRSRDCFFRGPCMLCFIVHSPGAPASAGLEEEPPLSPPPPPPRDGAYAAVSSQHLARRYAALAAEDCAAAARRFLLSSAAAAAAAASSPASCCKELGLAAAAAWEQQGRSLFLAGVGPVRFLGPLAAVQLFRAPPAPPPQAEPATALEMVCKRKGAGVPACTPCKQPRCGCGGCGGGGGGGGGPAGGGASPPRPPDAGCCQAPEQPPPPLCPAPASPASECAPIVAAAGDTVRAGGTAPSSAQQQPESGDADCQEPPENPCDCHREPPPEIPDINQLPPSILLKIFSNLSLNERCLSASLVCKYWRDLCLDFQFWKQLDLSSRQQVTDELLEKIASRSQNIIEINISDCRSLSDSGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSRCRELKDIHFGQCYKISDEGMIVIAKSCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITDYALIAIGRYSVTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNELTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNMSAATS
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteasome (By similarity). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (By similarity). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (PubMed:28883095). {ECO:0000250|UniProtKB:B1H1X1, ECO:0000250|UniProtKB:Q9UF56, ECO:0000269|PubMed:27234298, ECO:0000269|PubMed:28883095}.
uniprot
proteins
mass_dalton
75683
uniprot
proteins
protein_family
FBXL17 family
uniprot
proteins
pubmed
10531037
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
27234298
uniprot
proteins
pubmed
28883095
uniprot
proteins
sequence_length
701
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UF56}. Nucleus {ECO:0000250|UniProtKB:Q9UF56}. Note=Present in the cytoplasm and nucleus; more abundant in the cytoplasm. {ECO:0000250|UniProtKB:Q9UF56}.
uniprot
proteins