Pi4k2b
entrez
67073
canonical
uniprot
Q8CBQ5
canonical
ensembl
ENSMUSG00000029186
resolver
ensp
ENSMUSP00000031081
resolver
ensp
ENSMUSP00000031082
resolver
genesymbol
Pi4k2b
resolver
uniprot
Q91Z30
resolver
uniprot
Q9D072
resolver
uniprot
Q9D471
resolver
uniprot_entry
P4K2B_MOUSE
resolver
uniprot_sec
Q91Z30
resolver
uniprot_sec
Q9D072
resolver
uniprot_sec
Q9D471
resolver
amino_acid_sequence
MAEACEPTRPSEDEDEEREPLLPRVAWAQPRRVAPGSAVRMQADEGADVLREPATDEPPAVSGEGSISASLSTELDRTRTTSSETNTFLEDPEFADIVLKAEQAIEIGVFPERISQGSSGSYFVKDSKRNIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCLLPNQGYLSEAGAYLVDVKLNLGIVPKTKVVWLVSETFNYSAIDRAKSRGKKYALEKVPKVGRKFHRIGLPPKVGSFQLFVKDYKEAEYWLRRFEAEPLPENIRKQFQSQFEKLVILDYIIRNTDRGNDNWLVKYDEMKYAKKIESEESNWIDNKQLLIKIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKVPFSEETRNLILPYISDMNFVQDLCEDLYELFKTDKGFDRAAFENQMSVMRGQILNLTQALRDGKSPMQLAQMPCVIVECSKSGSQGRVVHLGSSFTQTVHCRKPFFSSW
uniprot
proteins
ec_number
2.7.1.67
uniprot
proteins
function
FUNCTION: Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. {ECO:0000250|UniProtKB:Q8TCG2}.
uniprot
proteins
mass_dalton
53478
uniprot
proteins
protein_family
PI3/PI4-kinase family
uniprot
proteins
protein_family
Type II PI4K subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8TCG2}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8TCG2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8TCG2}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8TCG2}. Cell membrane {ECO:0000250|UniProtKB:Q8TCG2}. Early endosome membrane {ECO:0000250|UniProtKB:Q8TCG2}. Note=Mainly cytosolic, association with membranes of the Golgi, endoplasmic and plasma membrane is stimulated by active RAC1. Association with early endosomes has not been confirmed. {ECO:0000250|UniProtKB:Q8TCG2}.
uniprot
proteins