PDE10A
entrez
10846
canonical
uniprot
Q9Y233
canonical
ensembl
ENSG00000112541
resolver
ensp
ENSP00000438284
resolver
ensp
ENSP00000497062
resolver
ensp
ENSP00000497392
resolver
ensp
ENSP00000497930
resolver
enst
ENST00000648884
resolver
genesymbol
PDE10A
resolver
hgnc
HGNC:8772
resolver
uniprot
A0A1B1UZQ1
resolver
uniprot
A0A1B1UZR0
resolver
uniprot
A0A3B3ISP3
resolver
uniprot
A0A3F2YP58
resolver
uniprot
Q6FHX1
resolver
uniprot
Q9HCP9
resolver
uniprot
Q9NTV4
resolver
uniprot
Q9ULW9
resolver
uniprot
Q9Y5T1
resolver
uniprot_entry
A0A1B1UZQ1_HUMAN
resolver
uniprot_entry
A0A1B1UZR0_HUMAN
resolver
uniprot_entry
A0A3B3ISP3_HUMAN
resolver
uniprot_entry
PDE10_HUMAN
resolver
uniprot_sec
A0A3F2YP58
resolver
uniprot_sec
Q6FHX1
resolver
uniprot_sec
Q9HCP9
resolver
uniprot_sec
Q9NTV4
resolver
uniprot_sec
Q9ULW9
resolver
uniprot_sec
Q9Y5T1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by dipyridamole and moderately by IBMX. cGMP acts as an allosteric activator. {ECO:0000269|PubMed:16330539}.
uniprot
proteins
amino_acid_sequence
MASLEEPLAPRPQGPLPAAGDEPGCGPGKLRPEPRLSAAGGGSAAGPGPAPEWPGRGRAERAAPPRPPLSSAGRPSPAGGPGALSARGGGCGWVAARAPLALAFSSRVPSSSPSFFYFWPPPPPPPPSFLPSSSAFHLPVRLPGREGAAAAAAAGGGGDAGGGGGGGQEAAPLSVPTSSSHRGGGGSGGGRRRLFLSPALQGLLLPARAGPRPPPPPRLPLGQAARRAGSPGFPGAGPGGGGQTPRRPQGASFALAAAAALLFGSDMEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
uniprot
proteins
disease_involvement
DISEASE: Dyskinesia, limb and orofacial, infantile-onset (IOLOD) [MIM:616921]: An autosomal recessive, early-onset hyperkinetic movement disorder characterized by axial hypotonia, dyskinesia of the limbs and trunk, orofacial dyskinesia, drooling, and dysarthria. The severity of the hyperkinesis is variable. {ECO:0000269|PubMed:27058446}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Striatal degeneration, autosomal dominant 2 (ADSD2) [MIM:616922]: An autosomal dominant disorder characterized by striatal degeneration and dysfunction of basal ganglia, resulting in hyperkinesis. {ECO:0000269|PubMed:27058447}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.4.17
uniprot
proteins
function
FUNCTION: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (PubMed:10373451, PubMed:10393245, PubMed:16330539, PubMed:17389385, PubMed:27058447). Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, PubMed:10393245, PubMed:17389385, PubMed:27058447). May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:27058447). {ECO:0000269|PubMed:10373451, ECO:0000269|PubMed:10393245, ECO:0000269|PubMed:16330539, ECO:0000269|PubMed:17389385, ECO:0000269|PubMed:27058447}.
uniprot
proteins
mass_dalton
114946
uniprot
proteins
mutagenesis
MUTAGEN 830; /note="D->A: Loss of activity and of zinc binding."; /evidence="ECO:0000269|PubMed:17389385"; MUTAGEN 830; /note="D->N: Reduces activity 1000-fold."; /evidence="ECO:0000269|PubMed:17389385
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. {ECO:0000269|PubMed:10373451, ECO:0000269|PubMed:10393245, ECO:0000269|PubMed:16330539, ECO:0000269|PubMed:17389385, ECO:0000269|PubMed:27058447}.; PATHWAY: Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1. {ECO:0000269|PubMed:10373451, ECO:0000269|PubMed:10393245, ECO:0000269|PubMed:17389385, ECO:0000269|PubMed:27058447}.
uniprot
proteins
post_translational_modification
PTM: [Isoform PDE10A2]: Phosphorylated on Thr-16. {ECO:0000269|PubMed:10441464}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
pubmed
10373451
uniprot
proteins
pubmed
10393245
uniprot
proteins
pubmed
10441464
uniprot
proteins
pubmed
10998054
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16330539
uniprot
proteins
pubmed
17389385
uniprot
proteins
pubmed
18477562
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
27058446
uniprot
proteins
pubmed
27058447
uniprot
proteins
sequence_length
1055
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10373451, ECO:0000269|PubMed:10441464}.
uniprot
proteins