Adrb2
entrez
11555
canonical
uniprot
P18762
canonical
ensembl
ENSMUSG00000045730
resolver
ensp
ENSMUSP00000062256
resolver
enst
ENSMUST00000053640
resolver
genesymbol
Adrb2
resolver
genesymbol_syn
Adrb2r
resolver
uniprot
Q8BH38
resolver
uniprot_entry
ADRB2_MOUSE
resolver
uniprot_sec
Q8BH38
resolver
amino_acid_sequence
MGPHGNDSDFLLAPNGSRAPDHDVTQERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAKFERLQTVTNYFIISLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYVAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHKKAIDCYTEETCCDFFTNQAYAIASSIVSFYVPLVVMVFVYSRVFQVAKRQLQKIDKSEGRFHAQNLSQVEQDGRSGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIRDNLIPKEVYILLNWLGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSSSKTYGNGYSSNSNGRTDYTGEPNTCQLGQEREQELLCEDPPGMEGFVNCQGTVPSLSVDSQGRNCSTNDSPL
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, activating bifurcated signaling pathways (PubMed:11171998, PubMed:18056263, PubMed:2834198). ADRB2 binds epinephrine (Epi) with an approximately 30-fold greater affinity than norepinephrine (NE) (PubMed:2834198). In the heart, Epi- and NE-activated ADRB2 induces rapid and slow cardiomyocyte contraction rate, respectively (PubMed:18056263). Both NE and Epi promote coupling to G(s)/PKA pathway to regulate myocyte contraction rate (PubMed:18056263). Epi also promotes ADRB2 coupling to G(i) proteins to exert cardioprotective effects especially in the conditions of hypoxia and oxidative stress through the G(i)/PI3K/Akt signaling pathway (PubMed:11171998, PubMed:18056263). ADRB2-G(s) signaling delivers proapoptotic signals in cardiomyocytes although G(i)-mediated survival effect appears to predominate (PubMed:11171998). ADRB2 also transduces signals independently of PKA to regulate cellular pH by modulating Na(+)/H(+) exchanger SLC9A3 function (By similarity). {ECO:0000250|UniProtKB:P07550, ECO:0000269|PubMed:11171998, ECO:0000269|PubMed:18056263, ECO:0000269|PubMed:2834198}.
uniprot
proteins
mass_dalton
46998
uniprot
proteins
post_translational_modification
PTM: Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (By similarity). {ECO:0000250}.; PTM: Phosphorylated by PKA and BARK/GRK2 upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK/GRK2 (By similarity). Distinct temporal phosphorylation on Ser-355 and Ser-356 by BARK/GRK2 plays a critical role for dictating receptor cellular events and signaling properties induced by Epi or NE in cardiomyocytes (PubMed:18056263). {ECO:0000250|UniProtKB:P07550, ECO:0000269|PubMed:18056263}.; PTM: Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor. {ECO:0000250}.; PTM: Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent (By similarity). {ECO:0000250}.; PTM: Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2. {ECO:0000250}.; PTM: Palmitoylated. Mainly palmitoylated at Cys-341. Palmitoylation may reduce accessibility of phosphorylation sites by anchoring the receptor to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation. Also undergoes transient, ligand-induced palmitoylation at Cys-265 probably by ZDHHC9, ZDHHC14 and ZDHHC18 within the Golgi. Palmitoylation at Cys-265 requires phosphorylation by PKA and receptor internalization and stabilizes the receptor. Could be depalmitoylated by LYPLA1 at the plasma membrane. {ECO:0000250|UniProtKB:P07550}.
uniprot
proteins
protein_family
ADRB2 sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11171998
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18056263
uniprot
proteins
pubmed
2549959
uniprot
proteins
pubmed
2834198
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18056263, ECO:0000269|PubMed:2834198}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P07550}. Golgi apparatus {ECO:0000250|UniProtKB:P07550}. Note=Colocalizes with VHL at the cell membrane. Activated receptors are internalized into endosomes prior to their degradation in lysosomes. Activated receptors are also detected within the Golgi apparatus. {ECO:0000250|UniProtKB:P07550}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..56; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P07550"; TRANSMEM 71..96; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P07550"; TRANSMEM 104..129; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P07550"; TRANSMEM 150..171; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P07550"; TRANSMEM 198..220; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P07550"; TRANSMEM 275..298; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P07550"; TRANSMEM 305..326; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P07550
uniprot
proteins