Atg9a
entrez
363254
canonical
uniprot
Q5FWU3
canonical
ensembl
ENSRNOG00000018975
resolver
ensembl
ENSRNOG00055010417
resolver
ensembl
ENSRNOG00060007814
resolver
ensembl
ENSRNOG00065008864
resolver
ensp
ENSRNOP00000104252
resolver
ensp
ENSRNOP00000105428
resolver
ensp
ENSRNOP00055014192
resolver
ensp
ENSRNOP00060009773
resolver
ensp
ENSRNOP00065010589
resolver
enst
ENSRNOT00000151583
resolver
enst
ENSRNOT00000172309
resolver
enst
ENSRNOT00055017630
resolver
enst
ENSRNOT00060012897
resolver
enst
ENSRNOT00065014154
resolver
genesymbol
Atg9a
resolver
genesymbol_syn
Apg9l1
resolver
uniprot
A0ABK0LUH1
resolver
uniprot_entry
A0ABK0LUH1_RAT
resolver
uniprot_entry
ATG9A_RAT
resolver
amino_acid_sequence
MAQFDTEYQRLEASYSDSPPGEEDLLVHVAEGSKSPWHHIENLDLFFSRVYNLHQKNGFTCMLIGEIFELMQFLFVVAFTTFLVSCVDYDILFANKMVNHSLHPTEPVKVTLPDAFLPAQVCSARIQENGSLITILVIAGVFWIHRLIKFIYNICCYWEIHSFYLHALRIPMSALPYCTWQEVQARIVQTQKEHQICIHKRELTELDIYHRILRFQNYMVALVNKSLLPLRFRLPGLGEVVFFTRGLKYNFELILFWGPGSLFLNEWSLKAEYKRGGQRLELAQRLSNRILWIGIANFLLCPLILIWQILYAFFSYAEVLKREPGALGARCWSLYGRCYLRHFNELEHELQSRLNRGYKPASKYMNCFLSPLLTLLAKNGAFFAGSILAVLIALTIYDEDVLAVEHVLTTVTLLGVTVTVCRSFIPDQHMVFCPEQLLRVILAHIHYMPDHWQGNAHRSQTRDEFAQLFQYKAVFILEELLSPIVTPLILIFCLRPRALEIIDFFRNFTVEVVGVGDTCSFAQMDVRQHGHPQWLSGGQTEASVYQQAEDGKTELSLMHFAITNPGWQPPRESTAFLGFLKEQVQRDGAAAGLAQGGLLPENALFTSIQSLQSESEPLSLIANVVAGSSCRGPPLSRDLQGSRHRADVASALRSFSPLQPGQAPQGRVPSTMTGSGVDARTASSGSSVWEGQLQSLVLSEYASTEMSLHALYMHQLHKQQTQAEPERHVWHRRESDESGESAPEEGGEGARAPQPIPRSASYPCATPRPGAPETTALHGGFQRRYGGITDPGTVPRAPSHFSRLPLGGWAEDGQPASRHPEPVPEEGSEDELPPQVHKV
uniprot
proteins
function
FUNCTION: Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (By similarity). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000250|UniProtKB:Q7Z3C6}.
uniprot
proteins
mass_dalton
94488
uniprot
proteins
post_translational_modification
PTM: Ufmylated in a DDRGK1 dependent manner. {ECO:0000250|UniProtKB:Q68FE2}.
uniprot
proteins
protein_family
ATG9 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
839
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Preautophagosomal structure membrane {ECO:0000250|UniProtKB:Q7Z3C6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7Z3C6}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q7Z3C6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7Z3C6}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q7Z3C6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7Z3C6}. Late endosome membrane {ECO:0000250|UniProtKB:Q7Z3C6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7Z3C6}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q7Z3C6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7Z3C6}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q7Z3C6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7Z3C6}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q7Z3C6}; Multi-pass membrane protein {ECO:0000255}. Note=Mainly localizes to the trans-Golgi network (TGN) and the endosomal system; cycles between them though vesicle trafficking. Export from the TGN to promote formation of autophagosomes is mediated by the AP-4 complex. Under amino acid starvation or rapamycin treatment, redistributes to preautophagosomal structure/phagophore assembly site (PAS). The starvation-induced redistribution depends on ULK1, ATG13, as well as SH3GLB1. Upon autophagy induction, a small portion transiently localizes to the autophagic membranes. Recruited to damaged mitochondria during mitophagy in a RIMOC1-dependent manner. {ECO:0000250|UniProtKB:Q7Z3C6}.
uniprot
proteins
transmembrane_region
TRANSMEM 62..84; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q7Z3C6"; TRANSMEM 129..154; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q7Z3C6"; TRANSMEM 372..397; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q7Z3C6"; TRANSMEM 407..424; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q7Z3C6
uniprot
proteins