Ift56
entrez
264134
canonical
uniprot
Q8BS45
canonical
ensembl
ENSMUSG00000056832
resolver
ensp
ENSMUSP00000124369
resolver
ensp
ENSMUSP00000213157
resolver
enst
ENSMUST00000162554
resolver
genesymbol
Ift56
resolver
genesymbol_syn
Hop
resolver
genesymbol_syn
Ttc26
resolver
uniprot_entry
IFT56_MOUSE
resolver
amino_acid_sequence
MMLSRAKPAVGGESPHTDKRKKKGRKIPKLEDLLSQRDFTGAITLLEFKRHVGEQEDDTNLWIGYCAFHLGDYKRALEEYENATKEENCNPEVWVNLACTYFFLGMYKQAEAAGFKAPKSRLQNRLLFHLAHKFNDEKKLMNFHQNLQDIKEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGKAAEAELKSLMDNASSPFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDDVQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMGSRDHMKIAQQFFQLVGGSASECDTIPGRQCMASCFFLLKQFDDVLIYLNSFKSYFYNDDIFNFNYAQAKAATGNTSEGEEVFLLIQSEKLKNDYIYLSWLARCYIMNKKPRLAWELYLKMETSGESFSLLQLIANDCYKMGQFYYSAKAFDVLERLDPNPEYWEGKRGACVGIFQMILAGREPKETLREVLHLLRSTGNTQVEYIIRIMKKWAKENRVPI
uniprot
proteins
function
FUNCTION: Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU (PubMed:22718903, PubMed:25340710). Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme (PubMed:28264835). {ECO:0000269|PubMed:22718903, ECO:0000269|PubMed:25340710, ECO:0000269|PubMed:28264835}.
uniprot
proteins
mass_dalton
64151
uniprot
proteins
protein_family
IFT56 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22718903
uniprot
proteins
pubmed
24596149
uniprot
proteins
pubmed
24692455
uniprot
proteins
pubmed
25340710
uniprot
proteins
pubmed
28264835
uniprot
proteins
pubmed
31595528
uniprot
proteins
sequence_length
554
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:22718903, ECO:0000269|PubMed:24596149}. Note=Localizes at the base to the ciliary transition zone. {ECO:0000269|PubMed:22718903, ECO:0000269|PubMed:24596149}.
uniprot
proteins