SP140
entrez
11262
canonical
uniprot
Q13342
canonical
ensembl
ENSG00000079263
resolver
ensp
ENSP00000342096
resolver
ensp
ENSP00000362749
resolver
ensp
ENSP00000375899
resolver
ensp
ENSP00000393618
resolver
ensp
ENSP00000398210
resolver
ensp
ENSP00000551983
resolver
ensp
ENSP00000551984
resolver
ensp
ENSP00000551985
resolver
ensp
ENSP00000551986
resolver
ensp
ENSP00000551987
resolver
ensp
ENSP00000551988
resolver
ensp
ENSP00000551989
resolver
ensp
ENSP00000551990
resolver
ensp
ENSP00000551991
resolver
ensp
ENSP00000551992
resolver
ensp
ENSP00000551994
resolver
ensp
ENSP00000619351
resolver
genesymbol
SP140
resolver
genesymbol_syn
LYSP100
resolver
hgnc
HGNC:17133
resolver
uniprot
B4DVW8
resolver
uniprot
E7ESH9
resolver
uniprot
E7EUR5
resolver
uniprot
E9PFJ6
resolver
uniprot
Q0VGE4
resolver
uniprot
Q0VGE5
resolver
uniprot
Q13341
resolver
uniprot
Q3KR17
resolver
uniprot
Q4ZG66
resolver
uniprot
Q53TG1
resolver
uniprot
Q6NSG4
resolver
uniprot
Q8IWJ1
resolver
uniprot
Q92881
resolver
uniprot
Q96TG3
resolver
uniprot_entry
B4DVW8_HUMAN
resolver
uniprot_entry
Q0VGE4_HUMAN
resolver
uniprot_entry
Q8IWJ1_HUMAN
resolver
uniprot_entry
SP140_HUMAN
resolver
uniprot_sec
E7ESH9
resolver
uniprot_sec
E7EUR5
resolver
uniprot_sec
E9PFJ6
resolver
uniprot_sec
Q0VGE5
resolver
uniprot_sec
Q13341
resolver
uniprot_sec
Q3KR17
resolver
uniprot_sec
Q4ZG66
resolver
uniprot_sec
Q53TG1
resolver
uniprot_sec
Q6NSG4
resolver
uniprot_sec
Q92881
resolver
uniprot_sec
Q96TG3
resolver
amino_acid_sequence
MAQQGQQGQMASGDSNLNFRMVAEIQNVEGQNLQEQVCPEPIFRFFRENKVEIASAITRPFPFLMGLRDRSFISEQMYEHFQEAFRNLVPVTRVMYCVLSELEKTFGWSHLEALFSRINLMAYPDLNEIYRSFQNVCYEHSPLQMNNVNDLEDRPRLLPYGKQENSNACHEMDDIAVPQEALSSSPRCEPGFSSESCEQLALPKAGGGDAEDAPSLLPGGGVSCKLAIQIDEGESEEMPKLLPYDTEVLESNGMIDAARTYSTAPGEKQGEEEGRNSPRKRNQDKEKYQESPEGRDKETFDLKTPQVTNEGEPEKGLCLLPGEGEEGSDDCSEMCDGEEPQEASSSLARCGSVSCLSAETFDLKTPQVTNEGEPEKELSLLPGEGEEGSDDCSEMCDGEERQEASSSLARRGSVSSELENHPMNEEGESEELASSLLYDNVPGAEQSAYENEKCSCVMCFSEEVPGSPEARTESDQACGTMDTVDIANNSTLGKPKRKRRKKRGHGWSRMRMRRQENSQQNDNSKADGQVVSSEKKANVNLKDLSKIRGRKRGKPGTRFTQSDRAAQKRVRSRASRKHKDETVDFKAPLLPVTCGGVKGILHKKKLQQGILVKCIQTEDGKWFTPTEFEIKGGHARSKNWRLSVRCGGWPLRWLMENGFLPDPPRIRYRKKKRILKSQNNSSVDPCMRNLDECEVCRDGGELFCCDTCSRVFHEDCHIPPVEAERTPWNCIFCRMKESPGSQQCCQESEVLERQMCPEEQLKCEFLLLKVYCCSESSFFAKIPYYYYIREACQGLKEPMWLDKIKKRLNEHGYPQVEGFVQDMRLIFQNHRASYKYKDFGQMGFRLEAEFEKNFKEVFAIQETNGNN
uniprot
proteins
function
FUNCTION: Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382). {ECO:0000269|PubMed:24267382, ECO:0000269|PubMed:8910577, ECO:0000303|PubMed:8910577}.
uniprot
proteins
mass_dalton
98223
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-726 promotes binding of PIN1 and subsequent isomerization of Pro-727. {ECO:0000269|PubMed:24267382}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
24267382
uniprot
proteins
pubmed
25593309
uniprot
proteins
pubmed
8695863
uniprot
proteins
pubmed
8910577
uniprot
proteins
sequence_length
867
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}. Nucleus, PML body {ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}. Cytoplasm {ECO:0000269|PubMed:8695863}. Note=Localized to nuclear structures termed LANDS, for LYSp100-associated nuclear domains. LANDS are globular, electron-dense structures most often found in the nucleoplasm, but also found at the nuclear membrane and in the cytoplasm, suggesting that these structures may traffic between the cytoplasm and the nucleus (PubMed:8695863). Also colocalizes with PML in a subset of PML nuclear bodies (PubMed:8910577). {ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}.
uniprot
proteins