Rad17
entrez
19356
canonical
uniprot
Q6NXW6
canonical
ensembl
ENSMUSG00000021635
resolver
ensp
ENSMUSP00000022136
resolver
ensp
ENSMUSP00000136292
resolver
ensp
ENSMUSP00000195749
resolver
enst
ENSMUST00000022136
resolver
enst
ENSMUST00000177848
resolver
genesymbol
Rad17
resolver
uniprot
O88934
resolver
uniprot
O89024
resolver
uniprot
Q3UYY2
resolver
uniprot_entry
Q3UYY2_MOUSE
resolver
uniprot_entry
RAD17_MOUSE
resolver
uniprot_sec
O88934
resolver
uniprot_sec
O89024
resolver
amino_acid_sequence
MSETFLRPKVSSTKVTDWVAPAFDDFEANTAITTITASSLTFSNSSHRRKYLPSTLESNRLSARKRGRLSLEQTHGLETSRERLSDNEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLEVKPKQGGSVLLITGPPGCGKTTTIKILSKELGIQVQEWVNPILPDFQKDDYKELLSLESNFSVVPYQSQIAVFNDFLLRATKYSKLQMLGDDLTTDKKIILVEELPNQFYRDPNALHEILRKHVQIGRCPLVFIVSDSVSGDNNQRLLFPRNIQEECSVSNISFNPVAPTIMMKFLNRIVTIEASKNGEKIIVPNKTSLELLCQGCSGDIRSAINSLQFSSSKGENSSWSKKKRMSLKSDAAISKSKQKKKHNSTLENQEIQAIGGKDVSLFLFRALGKILYCKRAPLTELDSPRLPAHLSEHDRDTLLVQPEEIVEMSHMPGDFFNLYLHQNYIDFFAEVDDLVPASEFLSFADILGGDWNTRSLLREYSTSVATRGVMHSNKARGFAHCQGGSSFRPLHKPQWFLIQKKYRENCLAAKALFVDFCLPALCLQTQLLPYLALLTIPMRNKAQISFIQDVGRLPLKRSFGRLKMEALTDRELGLIDPDSGDESPHSGGQPAQEAPGEPAQAAQNADPETWSLPLSQNSGSDLPASQPQPFSSKVDMEEEEEEEEDIIIEDYDSEET
uniprot
proteins
function
FUNCTION: Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (By similarity). Has a weak ATPase activity required for binding to chromatin (By similarity). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (By similarity). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (By similarity). May also serve as a sensor of DNA replication progression (By similarity). {ECO:0000250|UniProtKB:O75943}.
uniprot
proteins
mass_dalton
77391
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation on Ser-647 and Ser-657 is cell cycle-regulated, enhanced by genotoxic stress, and required for activation of checkpoint signaling (PubMed:11687627, PubMed:14500819, PubMed:17376776). Phosphorylation is mediated by ATR upon UV or replication arrest, whereas it may be mediated both by ATR and ATM upon ionizing radiation (By similarity). Phosphorylation on both sites is required for interaction with RAD1 but dispensable for interaction with RFC3 or RFC4 (By similarity). Phosphorylation by ATM in response to DNA damage promotes interaction with NBN and recruitment of the MRN complex to DNA damage sites (By similarity). {ECO:0000250|UniProtKB:O75943, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:17376776}.
uniprot
proteins
protein_family
Rad17/RAD24 family
uniprot
proteins
pubmed
10232579
uniprot
proteins
pubmed
10480350
uniprot
proteins
pubmed
11687627
uniprot
proteins
pubmed
14500819
uniprot
proteins
pubmed
15297881
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17376776
uniprot
proteins
pubmed
9933569
uniprot
proteins
sequence_length
688
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O75943}. Chromosome {ECO:0000250|UniProtKB:O75943}. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage. Localizes to DNA double-strand breaks (DSBs). {ECO:0000250|UniProtKB:O75943}.
uniprot
proteins