Glud1
entrez
24399
canonical
uniprot
P10860
canonical
ensembl
ENSRNOG00000057367
resolver
ensembl
ENSRNOG00055010531
resolver
ensembl
ENSRNOG00060013243
resolver
ensembl
ENSRNOG00065014146
resolver
ensp
ENSRNOP00000104584
resolver
ensp
ENSRNOP00055014368
resolver
ensp
ENSRNOP00060017893
resolver
ensp
ENSRNOP00065018194
resolver
enst
ENSRNOT00000137721
resolver
enst
ENSRNOT00055017845
resolver
enst
ENSRNOT00060022572
resolver
enst
ENSRNOT00065023379
resolver
genesymbol
Glud1
resolver
genesymbol_syn
Glud
resolver
uniprot
Q66HI8
resolver
uniprot
Q6LC16
resolver
uniprot_entry
DHE3_RAT
resolver
uniprot_sec
Q66HI8
resolver
uniprot_sec
Q6LC16
resolver
activity_regulation
ACTIVITY REGULATION: Subject to allosteric regulation. Activated by ADP. Inhibited by GTP and ATP. ADP can occupy the NADH binding site and activate the enzyme. Inhibited by SIRT4 (By similarity). Inhibited by HADH (By similarity). {ECO:0000250|UniProtKB:P00367, ECO:0000250|UniProtKB:P26443}.
uniprot
proteins
amino_acid_sequence
MYRRLGEVLLLSRAGPAALGSAAADSAALLGWARGQPSAVPQPGLTPVARRHYSEAATDREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRENEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGLGDKTFVVQGFGNVGLHSMRYLHRFGAKCVGVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKVYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPVVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT
uniprot
proteins
ec_number
1.4.1.3
uniprot
proteins
function
FUNCTION: Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). Plays a role in insulin homeostasis (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (PubMed:9275181). {ECO:0000250|UniProtKB:P00367, ECO:0000269|PubMed:9275181}.
uniprot
proteins
mass_dalton
61416
uniprot
proteins
post_translational_modification
PTM: ADP-ribosylated by SIRT4, leading to inactivate glutamate dehydrogenase activity. Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer. {ECO:0000250|UniProtKB:P00367}.
uniprot
proteins
protein_family
Glu/Leu/Phe/Val dehydrogenases family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1684101
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2704624
uniprot
proteins
pubmed
2704625
uniprot
proteins
pubmed
8094669
uniprot
proteins
pubmed
9275181
uniprot
proteins
sequence_length
558
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P00367}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P00367}. Note=Mostly translocates into the mitochondria, only a small amount of the protein localizes to the endoplasmic reticulum. {ECO:0000250|UniProtKB:P00367}.
uniprot
proteins