LDHA
entrez
3939
canonical
uniprot
P00338
canonical
ensembl
ENSG00000134333
resolver
ensembl
ENSG00000288299
resolver
ensp
ENSP00000227157
resolver
ensp
ENSP00000368722
resolver
ensp
ENSP00000379524
resolver
ensp
ENSP00000395337
resolver
ensp
ENSP00000406172
resolver
genesymbol
HEL-S-133P
resolver
genesymbol
LDHA
resolver
hgnc
HGNC:6535
resolver
uniprot
B4DKQ2
resolver
uniprot
B7Z5E3
resolver
uniprot
D3DQY3
resolver
uniprot
F8W819
resolver
uniprot
Q53G53
resolver
uniprot
Q6IBM7
resolver
uniprot
Q6ZNV1
resolver
uniprot
Q9UDE8
resolver
uniprot
Q9UDE9
resolver
uniprot
V9HWB9
resolver
uniprot_entry
LDHA_HUMAN
resolver
uniprot_entry
V9HWB9_HUMAN
resolver
uniprot_sec
B4DKQ2
resolver
uniprot_sec
B7Z5E3
resolver
uniprot_sec
D3DQY3
resolver
uniprot_sec
F8W819
resolver
uniprot_sec
Q53G53
resolver
uniprot_sec
Q6IBM7
resolver
uniprot_sec
Q6ZNV1
resolver
uniprot_sec
Q9UDE8
resolver
uniprot_sec
Q9UDE9
resolver
activity_regulation
ACTIVITY REGULATION: Fermentation of pyruvate to lactate is inhibited when bound to folliculin FLCN, perhaps partly by FLCN preventing binding of cofactor NADH (PubMed:34381247). {ECO:0000269|PubMed:34381247}.
uniprot
proteins
amino_acid_sequence
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
uniprot
proteins
disease_involvement
DISEASE: Glycogen storage disease 11 (GSD11) [MIM:612933]: A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue. {ECO:0000269|PubMed:2334430}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.1.1.27
uniprot
proteins
function
FUNCTION: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}.
uniprot
proteins
mass_dalton
36689
uniprot
proteins
mutagenesis
MUTAGEN 56; /note="D->A: Abolishes interaction with MP31."; /evidence="ECO:0000269|PubMed:33406399"; MUTAGEN 99; /note="R->A: Abolishes interaction with MP31."; /evidence="ECO:0000269|PubMed:33406399"; MUTAGEN 106; /note="R->A,K,Q: Increases binding to FLCN."; /evidence="ECO:0000269|PubMed:34381247
uniprot
proteins
pathway_participation
PATHWAY: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. {ECO:0000305|PubMed:11276087}.
uniprot
proteins
post_translational_modification
PTM: ISGylated. {ECO:0000269|PubMed:16139798}.
uniprot
proteins
protein_family
LDH family
uniprot
proteins
protein_family
LDH/MDH superfamily
uniprot
proteins
pubmed
10508479
uniprot
proteins
pubmed
11276087
uniprot
proteins
pubmed
1445373
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16139798
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
1953713
uniprot
proteins
pubmed
1959923
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2334430
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
3000353
uniprot
proteins
pubmed
33406399
uniprot
proteins
pubmed
33535099
uniprot
proteins
pubmed
34381247
uniprot
proteins
pubmed
3838278
uniprot
proteins
pubmed
7908613
uniprot
proteins
sequence_length
332
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins