Khdrbs2
entrez
170771
canonical
uniprot
Q9WU01
canonical
ensembl
ENSMUSG00000026058
resolver
ensp
ENSMUSP00000027226
resolver
ensp
ENSMUSP00000352763
resolver
genesymbol
Khdrbs2
resolver
genesymbol_syn
Slm1
resolver
uniprot
Q6NXZ3
resolver
uniprot_entry
KHDR2_MOUSE
resolver
uniprot_sec
Q6NXZ3
resolver
amino_acid_sequence
MGEEKYLPELMAEKDSLDPSFVHASRLLAEEIEKFQGSDGKKEDEEKKYLDVISNKNIKLSERVLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKTKEEELRKSGEAKYAHLSDELHVLIEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLRELSYLNGSEESGRGRGIRGRGIRITPTAPSRGRGGAVPPPPPPGRGVLTPRGTTVTRGALPVPPIARGVPTPRARGTAAVPGYRAPPPPAHDAYEEYGYDDGYGGEYDDQTYEAYDNSYVTPTQSVPEYYDYGHGVNEDAYDSYAPEEWATTRSSLKAPPPRSARGGYREHPYGRY
uniprot
proteins
function
FUNCTION: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion (By similarity). Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4 (PubMed:22196734, PubMed:24469635). Its phosphorylation by FYN inhibits its ability to regulate splice site selection (By similarity). May function as an adapter protein for Src kinases during mitosis (PubMed:10077576). {ECO:0000250|UniProtKB:Q920F3, ECO:0000269|PubMed:10077576, ECO:0000269|PubMed:15471878, ECO:0000269|PubMed:22196734, ECO:0000269|PubMed:24469635}.
uniprot
proteins
mass_dalton
38866
uniprot
proteins
post_translational_modification
PTM: Methylated. {ECO:0000250|UniProtKB:Q5VWX1}.; PTM: Tyrosine phosphorylated by FYN, PTK6 and SRC. Tyrosine phosphorylated by SRC during mitosis. {ECO:0000269|PubMed:10077576, ECO:0000269|PubMed:15471878}.
uniprot
proteins
protein_family
KHDRBS family
uniprot
proteins
pubmed
10077576
uniprot
proteins
pubmed
15471878
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22196734
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24469635
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10077576, ECO:0000269|PubMed:15471878}.
uniprot
proteins