RABGGTB
entrez
5876
canonical
uniprot
P53611
canonical
ensembl
ENSG00000137955
resolver
ensp
ENSP00000317473
resolver
enst
ENST00000319942
resolver
genesymbol
RABGGTB
resolver
genesymbol_syn
GGTB
resolver
hgnc
HGNC:9796
resolver
uniprot
A8KAJ2
resolver
uniprot
Q6IB63
resolver
uniprot
Q92697
resolver
uniprot_entry
A8KAJ2_HUMAN
resolver
uniprot_entry
PGTB2_HUMAN
resolver
uniprot_entry
Q6IB63_HUMAN
resolver
uniprot_sec
Q92697
resolver
activity_regulation
ACTIVITY REGULATION: The enzymatic reaction requires the aid of a Rab escort protein (also called component A). {ECO:0000269|PubMed:18532927}.
uniprot
proteins
amino_acid_sequence
MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDVNKVVEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVNPVFCMPEEVLQRVNVQPELVS
uniprot
proteins
ec_number
2.5.1.60
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A (PubMed:7991565). Catalytic subunit of the geranylgeranyl transferase type 3 (GGTase-3) complex (PubMed:31209342, PubMed:32128853). The GGTase-3 complex geranylgeranylates and targets FBXL2 to the cellular membranes, where FBXL2 forms part of the E3 ubiquitin-protein ligase complex SCF(FBXL2) that mediates the degradation of membrane-anchored proteins (PubMed:31209342, PubMed:32128853). The GGTase-3 complex geranylgeranylates Golgi v-SNARE protein YKT6 at 'Cys-194' and this prenylation is required for Golgi SNARE complex assembly (PubMed:32128853). {ECO:0000269|PubMed:31209342, ECO:0000269|PubMed:32128853, ECO:0000269|PubMed:7991565}.
uniprot
proteins
mass_dalton
36924
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="G->I,L: Abolishes geranylgeranylation of YKT6."; /evidence="ECO:0000269|PubMed:32128853
uniprot
proteins
protein_family
Protein prenyltransferase subunit beta family
uniprot
proteins
pubmed
11447212
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18532927
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26824392
uniprot
proteins
pubmed
31209342
uniprot
proteins
pubmed
32128853
uniprot
proteins
pubmed
7991565
uniprot
proteins
pubmed
8706741
uniprot
proteins
pubmed
8954794
uniprot
proteins
sequence_length
331
uniprot
proteins