Oxsr1
entrez
108737
canonical
uniprot
Q6P9R2
canonical
ensembl
ENSMUSG00000036737
resolver
ensp
ENSMUSP00000042155
resolver
enst
ENSMUST00000040853
resolver
genesymbol
Oxsr1
resolver
genesymbol_syn
Osr1
resolver
uniprot
Q8BVZ9
resolver
uniprot
Q8C0B9
resolver
uniprot_entry
OXSR1_MOUSE
resolver
uniprot_sec
Q8BVZ9
resolver
uniprot_sec
Q8C0B9
resolver
activity_regulation
ACTIVITY REGULATION: Activated following phosphorylation at Thr-185 by WNK kinases (WNK1, WNK2, WNK3 or WNK4). {ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:21486947}.
uniprot
proteins
amino_acid_sequence
MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKERVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEPTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKILQRAPTISERSKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGRAAISQLRSPRVKDSLSSSELFAAAEPMGTLLQVPEQISAHLPQPAGQMPTQPAQVSLLPPAEPAKPAQAQSSGERSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:17488636, PubMed:19633012, PubMed:21486947). Specifically recognizes and binds proteins with a RFXV motif (By similarity). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:12386165, PubMed:16382158, PubMed:17488636, PubMed:19633012, PubMed:21486947). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16382158, PubMed:21972418). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16382158). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:17488636, PubMed:19633012). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:21972418). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (By similarity). Phosphorylates RELL1, RELL2, RELT and PAK1 (By similarity). Phosphorylates PLSCR1 in the presence of RELT (By similarity). {ECO:0000250|UniProtKB:O95747, ECO:0000269|PubMed:12386165, ECO:0000269|PubMed:16382158, ECO:0000269|PubMed:17488636, ECO:0000269|PubMed:19633012, ECO:0000269|PubMed:21486947, ECO:0000269|PubMed:21972418}.
uniprot
proteins
mass_dalton
58214
uniprot
proteins
mutagenesis
MUTAGEN 185; /note="T->A: Impaired phosphorylation by WNK4 and activation. Knockin mice are unable to activate SLC12A3/NCC."; /evidence="ECO:0000269|PubMed:21486947
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-185 by WNK kinases (WNK1, WNK2, WNK3 or WNK4) is required for activation (PubMed:21486947). Autophosphorylated; promoting its activity (By similarity). {ECO:0000250|UniProtKB:O95747, ECO:0000269|PubMed:21486947}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
12386165
uniprot
proteins
pubmed
14707132
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16263722
uniprot
proteins
pubmed
16382158
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17488636
uniprot
proteins
pubmed
19633012
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21486947
uniprot
proteins
pubmed
21972418
uniprot
proteins
pubmed
23386621
uniprot
proteins
sequence_length
527
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O95747}.
uniprot
proteins