Pip4k2a
entrez
116723
canonical
uniprot
Q9R0I8
canonical
ensembl
ENSRNOG00000016670
resolver
ensembl
ENSRNOG00055010925
resolver
ensembl
ENSRNOG00060020405
resolver
ensembl
ENSRNOG00065003110
resolver
ensp
ENSRNOP00000022375
resolver
ensp
ENSRNOP00055014889
resolver
ensp
ENSRNOP00060029092
resolver
ensp
ENSRNOP00065003122
resolver
enst
ENSRNOT00000022375
resolver
enst
ENSRNOT00055018504
resolver
enst
ENSRNOT00060035398
resolver
enst
ENSRNOT00065004375
resolver
genesymbol
Pip4k2a
resolver
genesymbol_syn
Pip4ka
resolver
genesymbol_syn
Pip5k2a
resolver
uniprot_entry
PI42A_RAT
resolver
activity_regulation
ACTIVITY REGULATION: In rod outer segments, activated by light. {ECO:0000269|PubMed:20204506}.
uniprot
proteins
amino_acid_sequence
MATPSNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYVIKTITSEDVAEMHNILKKYHQYIVECHGVTLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDSNKKIFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENEGEEEGESDGAHPIGTPPDSPGNTLNSSPPLAPGEFDPNIDVYAIKCHENAPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT
uniprot
proteins
ec_number
2.7.1.149
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (By similarity). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (PubMed:20204506). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (By similarity). In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism. PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:21847559). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). {ECO:0000250|UniProtKB:O70172, ECO:0000250|UniProtKB:P48426, ECO:0000269|PubMed:20204506, ECO:0000269|PubMed:21847559}.
uniprot
proteins
mass_dalton
46210
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in tyrosines. Phosphorylation is induced by light and increases kinase activity. {ECO:0000269|PubMed:20204506}.
uniprot
proteins
pubmed
20204506
uniprot
proteins
pubmed
21847559
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O70172}. Nucleus {ECO:0000250|UniProtKB:P48426}. Lysosome {ECO:0000250|UniProtKB:O70172}. Cytoplasm {ECO:0000250|UniProtKB:P48426}. Photoreceptor inner segment {ECO:0000250|UniProtKB:O70172}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:O70172}. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B (By similarity). {ECO:0000250|UniProtKB:O70172, ECO:0000250|UniProtKB:P48426}.
uniprot
proteins