Asf1b
entrez
66929
canonical
uniprot
Q9DAP7
canonical
ensembl
ENSMUSG00000005470
resolver
ensp
ENSMUSP00000005607
resolver
enst
ENSMUST00000005607
resolver
genesymbol
Asf1b
resolver
uniprot
Q8BP41
resolver
uniprot
Q9CTX3
resolver
uniprot_entry
ASF1B_MOUSE
resolver
uniprot_sec
Q8BP41
resolver
uniprot_sec
Q9CTX3
resolver
amino_acid_sequence
MAKVSVLNVAVLENPSPFHSPFRFEISFECSEALSDDLEWKIIYVGSAESEEFDQILDSVLVGPVPAGRHMFVFQADAPNPSLIPETDAVGVTVVLITCTYHGQEFIRVGYYVNNEYPDPELRENPPPKPDFSQLQRNILASNPRVTRFHINWDNNPDSLEAIENQDPNVDFSLSLSCTPVKSLGLPSCIPGLLPENSMDCI
uniprot
proteins
function
FUNCTION: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:12842904, PubMed:17054786). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (By similarity). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5ac and H4K12ac) marks in the cytosol (By similarity). Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (By similarity). Required for gonad development (PubMed:26850882). {ECO:0000250|UniProtKB:Q9NVP2, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:17054786, ECO:0000269|PubMed:26850882}.
uniprot
proteins
mass_dalton
22464
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by TLK2 (By similarity). Phosphorylated by TLK1 (PubMed:17054786). {ECO:0000250|UniProtKB:Q9NVP2, ECO:0000269|PubMed:17054786}.
uniprot
proteins
protein_family
ASF1 family
uniprot
proteins
pubmed
12842904
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17054786
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26850882
uniprot
proteins
sequence_length
202
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NVP2}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9NVP2}.
uniprot
proteins