Pde6b
entrez
289878
canonical
uniprot
D3ZDI8
canonical
ensembl
ENSRNOG00000000065
resolver
ensembl
ENSRNOG00055027157
resolver
ensembl
ENSRNOG00060011473
resolver
ensembl
ENSRNOG00065012459
resolver
ensp
ENSRNOP00000000077
resolver
ensp
ENSRNOP00055038569
resolver
ensp
ENSRNOP00060015232
resolver
ensp
ENSRNOP00065015578
resolver
enst
ENSRNOT00000000077
resolver
enst
ENSRNOT00055046948
resolver
enst
ENSRNOT00060019415
resolver
enst
ENSRNOT00065020280
resolver
genesymbol
Pde6b
resolver
uniprot_entry
PDE6B_RAT
resolver
amino_acid_sequence
MSLSEEQVRSFLDGNPTFAHQYFEKKLSPENVAGACEGGCLVDCGSLRELCQVEESAALFELVQDMQESVNMERVVFKVLRRLCTILHADRCSLFMYRQRNGVAELATRLFSVQPDSLLEDCLVPPDSEIVFPLDIGIVGHVAQTKKMINVQDVAECPHFSPFADELTDYVTKNILSTPIMNGKDVVAVIMAVNKLDGPCFTSEDEDVFTKYLNFATLNLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCDRYSVGLLDMTKEKEFFDVWPVLMGEAQPYSGPRTPDGREIVFYKVIDYILHGKEDIKVIPTPPADHWALTSGLPTYVAESGFICNIMNASADEMFNFQEGPLDESGWVIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDDQDEVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQDMVLYHVRCDKDEIQEILPTRDRLGKEPADCEEDELGKILKEELPGPTKFDIYEFHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVLVRFLFSVSKAYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLAEESLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDESKNYEDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEEKKKEEDRVAAKKAGTEICNGGPAPKSSTCCIL
uniprot
proteins
ec_number
3.1.4.35
uniprot
proteins
function
FUNCTION: Catalytic beta subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits (PDE6G). Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification. Decreased cytosolic cGMP levels result in closure of cGMP-gated cation channels at the plasma membrane, leading to rod photoreceptor hyperpolarization (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity). {ECO:0000250|UniProtKB:P23440, ECO:0000250|UniProtKB:P35913}.
uniprot
proteins
mass_dalton
98492
uniprot
proteins
post_translational_modification
PTM: Geranylgeranylated. This modification is required for association with the rod photoreceptor disk membrane. {ECO:0000269|PubMed:1309771}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
pubmed
1309771
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
856
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P35913}; Lipid-anchor {ECO:0000269|PubMed:1309771}. Membrane {ECO:0000250|UniProtKB:P23439}; Lipid-anchor {ECO:0000269|PubMed:1309771}.
uniprot
proteins