Elf3
entrez
13710
canonical
uniprot
Q3UPW2
canonical
ensembl
ENSMUSG00000003051
resolver
ensp
ENSMUSP00000003135
resolver
ensp
ENSMUSP00000139769
resolver
genesymbol
Elf3
resolver
genesymbol_syn
Ert
resolver
genesymbol_syn
Esx
resolver
genesymbol_syn
Jen
resolver
uniprot
B7ZNQ9
resolver
uniprot
B9EI01
resolver
uniprot
O35275
resolver
uniprot_entry
ELF3_MOUSE
resolver
uniprot_sec
B7ZNQ9
resolver
uniprot_sec
B9EI01
resolver
uniprot_sec
O35275
resolver
amino_acid_sequence
MAATCEISNVFSNYFNAMYSSEDPTLAPAPPTTFGTEDLVLTLNNQQMTLEGPGPQTRSQRDRTDPLAVLHLAEKASWTSERPQFWSKTQVLEWISYQVEKNKYDASSIDFSRCDMDGATLCSCALEELRLVFGPLGDQLHAQLRDLTSNSSDELSWIIELLEKDGMSFQESLGDSGPFDQGSPFAQELLDDGRQASPYYCSTYGPGAPSPGSSDVSTARTATPQSSHASDSGGSDVDLDLTESKVFPRDGFPDYKKGEPKHGKRKRGRPRKLSKEYWDCLEGKKSKHAPRGTHLWEFIRDILIHPELNEGLMKWENRHEGVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNSSGWKEEEVGESRN
uniprot
proteins
function
FUNCTION: Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter (By similarity). Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity (By similarity). Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway (By similarity). May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development. {ECO:0000250|UniProtKB:P78545, ECO:0000269|PubMed:11893733, ECO:0000269|PubMed:11984530, ECO:0000269|PubMed:16630543, ECO:0000269|PubMed:9806763}.
uniprot
proteins
mass_dalton
44273
uniprot
proteins
mutagenesis
MUTAGEN 153; /note="D->A: Slight reduction in transactivation activity."; /evidence="ECO:0000269|PubMed:11893733"; MUTAGEN 162; /note="L->P: Significant loss of transactivation activity."; /evidence="ECO:0000269|PubMed:11893733"; MUTAGEN 264..267; /note="KRKR->AAAA: Abrogates nuclear localization activity."; /evidence="ECO:0000269|PubMed:16516205"; MUTAGEN 269..272; /note="RPRK->APAA: Clear and exclusive nuclear accumulation."; /evidence="ECO:0000269|PubMed:16516205"; MUTAGEN 338..340; /note="KKK->AAA: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:16516205
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
11025204
uniprot
proteins
pubmed
11893733
uniprot
proteins
pubmed
11984530
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16516205
uniprot
proteins
pubmed
16630543
uniprot
proteins
pubmed
9395241
uniprot
proteins
pubmed
9806763
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P78545}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:16516205}.
uniprot
proteins