PSPC1
entrez
55269
canonical
uniprot
Q8WXF1
canonical
ensembl
ENSG00000121390
resolver
ensp
ENSP00000343966
resolver
ensp
ENSP00000481916
resolver
ensp
ENSP00000674789
resolver
ensp
ENSP00000674792
resolver
ensp
ENSP00000674796
resolver
ensp
ENSP00000674798
resolver
ensp
ENSP00000684785
resolver
genesymbol
PSPC1
resolver
genesymbol_syn
PSP1
resolver
hgnc
HGNC:20320
resolver
uniprot
Q5JTQ3
resolver
uniprot
Q8NCZ9
resolver
uniprot
Q8WXE8
resolver
uniprot
Q9NV36
resolver
uniprot_entry
PSPC1_HUMAN
resolver
uniprot_sec
Q5JTQ3
resolver
uniprot_sec
Q8NCZ9
resolver
uniprot_sec
Q8WXE8
resolver
uniprot_sec
Q9NV36
resolver
amino_acid_sequence
MMLRGNLKQVRIEKNPARLRALESAVGESEPAAAAAMALALAGEPAPPAPAPPEDHPDEEMGFTIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEKLMQKTQQYHKEREQPPRFAQPGTFEFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLMRQDLMRRQEELRRLEELRNQELQKRKQIQLRHEEEHRRREEEMIRHREQEELRRQQEGFKPNYMENREQEMRMGDMGPRGAINMGDAFSPAPAGNQGPPPMMGMNMNNRATIPGPPMGPGPAMGPEGAANMGTPMMPDNGAVHNDRFPQGPPSQMGSPMGSRTGSETPQAPMSGVGPVSGGPGGFGRGSQGGNFEGPNKRRRY
uniprot
proteins
function
FUNCTION: RNA-binding protein required for the formation of nuclear paraspeckles (PubMed:22416126). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (PubMed:22416126). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8R326, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}.
uniprot
proteins
mass_dalton
58744
uniprot
proteins
mutagenesis
MUTAGEN 119; /note="F->A: Abolishes accumulation in paraspeckles, but not in perinucleolar caps; when associated with A-121; A-198 and A-200."; /evidence="ECO:0000269|PubMed:16148043"; MUTAGEN 121; /note="F->A: Abolishes accumulation in paraspeckles, but not in perinucleolar caps; when associated with A-119; A-198 and A-200."; /evidence="ECO:0000269|PubMed:16148043"; MUTAGEN 198; /note="K->A: Abolishes accumulation in paraspeckles, but not in perinucleolar caps; when associated with A-119; A-121 and A-200."; /evidence="ECO:0000269|PubMed:16148043"; MUTAGEN 200; /note="F->A: Abolishes accumulation in paraspeckles, but not in perinucleolar caps; when associated with A-119; A-121 and A-198."; /evidence="ECO:0000269|PubMed:16148043"; MUTAGEN 275; /note="Y->A: Abolishes interaction with NONO and localization in nuclear paraspeckles; when associated with A-279."; /evidence="ECO:0000269|PubMed:22416126"; MUTAGEN 279; /note="W->A: Abolishes interaction with NONO and localization in nuclear paraspeckles; when associated with A-275."; /evidence="ECO:0000269|PubMed:22416126
uniprot
proteins
protein_family
PSPC family
uniprot
proteins
pubmed
11790299
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16148043
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22416126
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28712728
uniprot
proteins
pubmed
37369679
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:11790299, ECO:0000269|PubMed:16148043, ECO:0000269|PubMed:28712728}. Nucleus, nucleolus {ECO:0000269|PubMed:11790299}. Nucleus matrix {ECO:0000250|UniProtKB:Q8R326}. Cytoplasm {ECO:0000250|UniProtKB:Q8R326}. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles (PubMed:11790299, PubMed:16148043). Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner (PubMed:11790299, PubMed:16148043). May cycle between paraspeckles and nucleolus (PubMed:11790299). In telophase, when daughter nuclei form, localizes to perinucleolar caps (PubMed:11790299). {ECO:0000269|PubMed:11790299, ECO:0000269|PubMed:16148043}.
uniprot
proteins