TGS1
entrez
96764
canonical
uniprot
Q96RS0
canonical
ensembl
ENSG00000137574
resolver
ensp
ENSP00000260129
resolver
ensp
ENSP00000681293
resolver
ensp
ENSP00000729562
resolver
enst
ENST00000260129
resolver
genesymbol
TGS1
resolver
genesymbol_syn
HCA137
resolver
genesymbol_syn
NCOA6IP
resolver
genesymbol_syn
PIMT
resolver
hgnc
HGNC:17843
resolver
uniprot
A6NJQ5
resolver
uniprot
Q5GH23
resolver
uniprot
Q8TDG9
resolver
uniprot
Q96QU3
resolver
uniprot
Q9H5V3
resolver
uniprot_entry
TGS1_HUMAN
resolver
uniprot_sec
A6NJQ5
resolver
uniprot_sec
Q5GH23
resolver
uniprot_sec
Q8TDG9
resolver
uniprot_sec
Q96QU3
resolver
uniprot_sec
Q9H5V3
resolver
amino_acid_sequence
MCCEKWSRVAEMFLFIEEREDCKILCLCSRAFVEDRKLYNLGLKGYYIRDSGNNSGDQATEEEEGGYSCGTAESHDSKGIGLDESELDSEAELMRSMGLPLQFGRITAHKDFEVSMNTRNKVKIKKKKHQKKYLDEIVQESWRKEYEEDDILASDDPSSIEQYENTRTYELQSKKDTETENPPVENTLSPKLEITEKWEKYWNEYGGGLLWQSWQEKHPGQALSSEPWNFPDTKEEWEQHYSQLYWYYLEQFQYWEAQGWTFDASQSCDTDTYTSKTEADDKNDEKCMKVDLVSFPSSPIMVDNDSSGTSDKDHSEILDGISNIKLNSEEVTQSQLDSCTSHDGHQQLSEVSSKRECPASGQSEPRNGGTNEESNSSGNTNTDPPAEDSQKSSGANTSKDRPHASGTDGDESEEDPPEHKPSKLKRSHELDIDENPASDFDDSGSLLGFKYGSGQKYGGIPNFSHRQVRYLEKNVKLKSKYLDMRRQIKMKNKHIFFTKESEKPFFKKSKILSKVEKFLTWVNKPMDEEASQESSSHDNVHDASTSSDSEEQDMSVKKGDDLLETNNPEPEKCQSVSSAGELETENYERDSLLATVPDEQDCVTQEVPDSRQAETEAEVKKKKNKKKNKKVNGLPPEIAAVPELAKYWAQRYRLFSRFDDGIKLDREGWFSVTPEKIAEHIAGRVSQSFKCDVVVDAFCGVGGNTIQFALTGMRVIAIDIDPVKIALARNNAEVYGIADKIEFICGDFLLLASFLKADVVFLSPPWGGPDYATAETFDIRTMMSPDGFEIFRLSKKITNNIVYFLPRNADIDQVASLAGPGGQVEIEQNFLNNKLKTITAYFGDLIRRPASET
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}.
uniprot
proteins
mass_dalton
96620
uniprot
proteins
mutagenesis
MUTAGEN 655; /note="F->A: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:18775984"; MUTAGEN 673; /note="T->A: Decreases catalytic activity to 13 percent of wild type."; /evidence="ECO:0000269|PubMed:18775984"; MUTAGEN 696; /note="D->A: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:18775984"; MUTAGEN 704; /note="N->A: Decreases catalytic activity to 5 percent of wild type."; /evidence="ECO:0000269|PubMed:18775984"; MUTAGEN 719; /note="D->A: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:18775984"; MUTAGEN 731; /note="N->A: Decreases catalytic activity to 4 percent of wild type."; /evidence="ECO:0000269|PubMed:18775984"; MUTAGEN 763; /note="S->A: Decreases catalytic activity to 26 percent of wild type."; /evidence="ECO:0000269|PubMed:18775984, ECO:0000269|PubMed:19386620"; MUTAGEN 766; /note="W->A: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:18775984, ECO:0000269|PubMed:19386620"; MUTAGEN 807; /note="R->A: Decreases catalytic activity to 6 percent of wild type."; /evidence="ECO:0000269|PubMed:18775984"; MUTAGEN 808; /note="N->A: Decreases catalytic activity to 11 percent of wild type."; /evidence="ECO:0000269|PubMed:18775984
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
protein_family
Trimethylguanosine synthase family
uniprot
proteins
pubmed
11517327
uniprot
proteins
pubmed
11912212
uniprot
proteins
pubmed
12032086
uniprot
proteins
pubmed
12097419
uniprot
proteins
pubmed
12200376
uniprot
proteins
pubmed
12776181
uniprot
proteins
pubmed
12943661
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16687569
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18775984
uniprot
proteins
pubmed
19307714
uniprot
proteins
pubmed
19386620
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
853
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12943661}. Nucleus, Cajal body {ECO:0000305|PubMed:12032086}. Nucleus, nucleolus {ECO:0000269|PubMed:12032086}. Note=A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network. {ECO:0000269|PubMed:12943661}.
uniprot
proteins