PANK1
entrez
53354
canonical
uniprot
Q8TE04
canonical
ensembl
ENSG00000152782
resolver
ensp
ENSP00000302108
resolver
ensp
ENSP00000318526
resolver
ensp
ENSP00000345118
resolver
enst
ENST00000307534
resolver
genesymbol
PANK1
resolver
genesymbol_syn
PANK
resolver
hgnc
HGNC:8598
resolver
uniprot
A0A8C8KBT8
resolver
uniprot
A6NIP0
resolver
uniprot
Q7RTX6
resolver
uniprot
Q7Z495
resolver
uniprot
Q8TBQ8
resolver
uniprot_entry
A0A8C8KBT8_HUMAN
resolver
uniprot_entry
PANK1_HUMAN
resolver
uniprot_sec
A6NIP0
resolver
uniprot_sec
Q7RTX6
resolver
uniprot_sec
Q7Z495
resolver
uniprot_sec
Q8TBQ8
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by feedback inhibition by CoA and its thioesters. {ECO:0000269|PubMed:17631502}.
uniprot
proteins
amino_acid_sequence
MLKLVGGGGGQDWACSVAGTSLGGEEAAFEVARPGDQGKAGGGSPGWGCAGIPDSAPGAGVLQAGAVGPARGGQGAEEVGESAGGGEERRVRHPQAPALRLLNRKPQGGSGEIKTPENDLQRGRLSRGPRTAPPAPGMGDRSGQQERSVPHSPGAPVGTSAAAVNGLLHNGFHPPPVQPPHVCSRGPVGGSDAAPQRLPLLPELQPQPLLPQHDSPAKKCRLRRRMDSGRKNRPPFPWFGMDIGGTLVKLVYFEPKDITAEEEQEEVENLKSIRKYLTSNTAYGKTGIRDVHLELKNLTMCGRKGNLHFIRFPSCAMHRFIQMGSEKNFSSLHTTLCATGGGAFKFEEDFRMIADLQLHKLDELDCLIQGLLYVDSVGFNGKPECYYFENPTNPELCQKKPYCLDNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNMMSKEKRDSISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLLAYAMDFWSKGQLKALFLEHEGYFGAVGALLELFKMTDDK
uniprot
proteins
ec_number
2.7.1.33
uniprot
proteins
function
FUNCTION: [Isoform 1]: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269|PubMed:14523052, ECO:0000269|PubMed:17631502}.
uniprot
proteins
mass_dalton
64339
uniprot
proteins
mutagenesis
MUTAGEN 218..233; /note="KKCRLRRRMDSGRKNR->AACALAAAMDSGAANA: Loss of nuclear localization."; /evidence="ECO:0000269|PubMed:23152917
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. {ECO:0000269|PubMed:14523052, ECO:0000269|PubMed:17631502}.
uniprot
proteins
protein_family
Type II pantothenate kinase family
uniprot
proteins
pubmed
11479594
uniprot
proteins
pubmed
11809413
uniprot
proteins
pubmed
14523052
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17631502
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23152917
uniprot
proteins
sequence_length
598
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14523052}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:23152917}. Nucleus, nucleolus {ECO:0000269|PubMed:23152917}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:23152917}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:23152917}. Recycling endosome {ECO:0000269|PubMed:23152917}.
uniprot
proteins