OAZ3
entrez
51686
canonical
uniprot
Q9UMX2
canonical
ensembl
ENSG00000143450
resolver
ensp
ENSP00000313922
resolver
ensp
ENSP00000383784
resolver
ensp
ENSP00000415904
resolver
enst
ENST00000321531
resolver
enst
ENST00000453029
resolver
genesymbol
OAZ3
resolver
hgnc
HGNC:8097
resolver
uniprot
A0A0G2JH29
resolver
uniprot
E7EUE7
resolver
uniprot
H0Y7Y4
resolver
uniprot
Q6GMR0
resolver
uniprot_entry
A0A0G2JH29_HUMAN
resolver
uniprot_entry
H0Y7Y4_HUMAN
resolver
uniprot_entry
OAZ3_HUMAN
resolver
uniprot_sec
E7EUE7
resolver
uniprot_sec
Q6GMR0
resolver
amino_acid_sequence
MPCKRCRPSVYSLSYIKRGKTRNYLYPIWSPYAYYLYCYKYRITLREKMLPRCYKSITYKEEEDLTLQPRSCLQCSESLVGLQEGKSTEQGNHDQLKELYSAGNLTVLATDPLLHQDPVQLDFHFRLTSQTSAHWHGLLCDRRLFLDIPYQALDQGNRESLTATLEYVEEKTNVDSVFVNFQNDRNDRGALLRAFSYMGFEVVRPDHPALPPLDNVIFMVYPLERDVGHLPSEPP
uniprot
proteins
function
FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity). {ECO:0000250|UniProtKB:Q9R109, ECO:0000269|PubMed:17900240}.
uniprot
proteins
mass_dalton
27413
uniprot
proteins
protein_family
ODC antizyme family
uniprot
proteins
pubmed
10781085
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17900240
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}.
uniprot
proteins