Samsn1
entrez
67742
canonical
uniprot
P57725
canonical
ensembl
ENSMUSG00000022876
resolver
ensp
ENSMUSP00000109877
resolver
enst
ENSMUST00000114239
resolver
genesymbol
Samsn1
resolver
uniprot
Q2LE09
resolver
uniprot
Q5RKU0
resolver
uniprot
Q6P210
resolver
uniprot
Q8C6S2
resolver
uniprot_entry
SAMN1_MOUSE
resolver
uniprot_sec
Q2LE09
resolver
uniprot_sec
Q5RKU0
resolver
uniprot_sec
Q6P210
resolver
uniprot_sec
Q8C6S2
resolver
amino_acid_sequence
MLKRKPSNASDKEKHQKPKRSSSFGNFDRFRNNSVSKSDDSIEVHDRELTNGSEEQSKTSSSGGSLGKKVRAISWTMKKKVGKKYIKALSEEKEEESGEEALPYRNSDPMIGTHTEKISLKASDSMDSLYSGQSSSSGITSCSDGTSNRDSFRLDDDSPYSGPFCGRAKVHTDFTPSPYDTDSLKIKKGDIIDIICKTPMGMWTGMLNNKVGNFKFIYVDVILEEEAAPKKIKVPRSRRRENHQTIQEFLERIHLQEYTSTLLLNGYETLDDLKDIKESHLIELNIADPEDRARLLSAAESLLDEETTVEHEKESVPLSSNPDILSASQLEDCPRDSGCYISSENSDNGKEDLESENLSDMVQKIAITESSD
uniprot
proteins
function
FUNCTION: Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation. {ECO:0000269|PubMed:15381729, ECO:0000269|PubMed:19923443, ECO:0000269|PubMed:20478393, ECO:0000269|PubMed:21296879}.
uniprot
proteins
mass_dalton
41601
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="S->A: Loss of phosphorylation site. Strongly reduced interaction with YWHAG and YWHAB."; /evidence="ECO:0000269|PubMed:20478393
uniprot
proteins
pubmed
15381729
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19923443
uniprot
proteins
pubmed
20478393
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21296879
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cell projection, ruffle. Note=Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles.
uniprot
proteins