FCGRT
entrez
2217
canonical
uniprot
P55899
canonical
ensembl
ENSG00000104870
resolver
ensp
ENSP00000221466
resolver
ensp
ENSP00000410798
resolver
ensp
ENSP00000471118
resolver
ensp
ENSP00000569094
resolver
ensp
ENSP00000569095
resolver
ensp
ENSP00000569099
resolver
ensp
ENSP00000569100
resolver
ensp
ENSP00000569103
resolver
ensp
ENSP00000569104
resolver
ensp
ENSP00000569107
resolver
ensp
ENSP00000569111
resolver
ensp
ENSP00000631937
resolver
ensp
ENSP00000631942
resolver
ensp
ENSP00000631944
resolver
ensp
ENSP00000631945
resolver
ensp
ENSP00000631946
resolver
ensp
ENSP00000631947
resolver
ensp
ENSP00000650151
resolver
ensp
ENSP00000650157
resolver
enst
ENST00000221466
resolver
enst
ENST00000426395
resolver
enst
ENST00000596975
resolver
enst
ENST00000899035
resolver
enst
ENST00000899036
resolver
enst
ENST00000899040
resolver
enst
ENST00000899041
resolver
enst
ENST00000899044
resolver
enst
ENST00000899045
resolver
enst
ENST00000899052
resolver
enst
ENST00000961878
resolver
enst
ENST00000961883
resolver
enst
ENST00000961885
resolver
enst
ENST00000961886
resolver
enst
ENST00000961887
resolver
enst
ENST00000961888
resolver
genesymbol
FCGRT
resolver
genesymbol_syn
FCRN
resolver
hgnc
HGNC:3621
resolver
uniprot
A0A024QZI2
resolver
uniprot
M0R0A9
resolver
uniprot
Q5HYM5
resolver
uniprot
Q9HBV7
resolver
uniprot
Q9NZ19
resolver
uniprot_entry
A0A024QZI2_HUMAN
resolver
uniprot_entry
FCGRN_HUMAN
resolver
uniprot_entry
M0R0A9_HUMAN
resolver
uniprot_sec
Q5HYM5
resolver
uniprot_sec
Q9HBV7
resolver
uniprot_sec
Q9NZ19
resolver
amino_acid_sequence
MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
uniprot
proteins
function
FUNCTION: Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:10933786, PubMed:7964511). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995). {ECO:0000250|UniProtKB:P13599, ECO:0000269|PubMed:10933786, ECO:0000269|PubMed:10998088, ECO:0000269|PubMed:24469444, ECO:0000269|PubMed:28330995, ECO:0000269|PubMed:7964511}.; FUNCTION: (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29. {ECO:0000269|PubMed:30808762, ECO:0000269|PubMed:31104841}.
uniprot
proteins
mass_dalton
39743
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
10933786
uniprot
proteins
pubmed
10998088
uniprot
proteins
pubmed
12578848
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24469444
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28330995
uniprot
proteins
pubmed
30808762
uniprot
proteins
pubmed
31104841
uniprot
proteins
pubmed
7964511
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P13599}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:31104841}.
uniprot
proteins
transmembrane_region
TRANSMEM 298..321; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins