Nelfb
entrez
58202
canonical
uniprot
Q8C4Y3
canonical
ensembl
ENSMUSG00000013465
resolver
ensp
ENSMUSP00000057731
resolver
genesymbol
Nelfb
resolver
genesymbol_syn
Cobra1
resolver
uniprot
A0A0X1KG62
resolver
uniprot
Q69ZP4
resolver
uniprot
Q99J41
resolver
uniprot
Q9JJA5
resolver
uniprot_entry
NELFB_MOUSE
resolver
uniprot_sec
A0A0X1KG62
resolver
uniprot_sec
Q69ZP4
resolver
uniprot_sec
Q99J41
resolver
uniprot_sec
Q9JJA5
resolver
amino_acid_sequence
MATLEAAGERGLGGPRGTVERASGAPSGSATAPAERGGDGVHSRASAGASAMFAGLQDLGVANGEDLKETLTNCTEPLKAIEQFQTENGVLLPSLQSALPFLDLHGTPRLEFHQSVFDELRDKLLERVSAIASEGKAEERYKKLEDLLEKSFSLVKMPSLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFSTELSVLHNFFSPSPKTRRQGEVVQKLTQMVGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLMSLHDLDVSDICTVDPCHKFTWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGDLSMILCDPFAINTLSLSTIRHLQELVSQETLPRDSPDLLLLLRLLALGQGAWDLIDSQVFKEPKMEAELITKFLPMLMSLVVDDFTFNVDQKLPAEEKASVTYPNTLPESFTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLVETFGDLAFSDIFLHLLTGSLVLLADEFALEDFCSSLFDGFFLTASPRKENVHRHVLRLLLHLHARVAPSKLEALQKALEPTGQSGEAVKELYSQLGEKLEQLDHRKPSPTQAAETPALDLPLPSVPAPATL
uniprot
proteins
function
FUNCTION: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (Pol II) (PubMed:25773599). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). May be able to induce chromatin unfolding (By similarity). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (PubMed:19340312). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (PubMed:25773599). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (PubMed:24656816). {ECO:0000250|UniProtKB:Q8WX92, ECO:0000269|PubMed:19340312, ECO:0000269|PubMed:24656816, ECO:0000269|PubMed:25773599}.
uniprot
proteins
mass_dalton
70339
uniprot
proteins
protein_family
NELF-B family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19340312
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24656816
uniprot
proteins
pubmed
25773599
uniprot
proteins
pubmed
26010750
uniprot
proteins
sequence_length
631
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WX92}.
uniprot
proteins