Cadm2
entrez
360687
canonical
uniprot
Q1WIM2
canonical
ensembl
ENSRNOG00000074750
resolver
ensp
ENSRNOP00000099794
resolver
ensp
ENSRNOP00000108195
resolver
ensp
ENSRNOP00000109645
resolver
genesymbol
Cadm2
resolver
genesymbol_syn
Igsf4d
resolver
genesymbol_syn
Necl3
resolver
uniprot_entry
CADM2_RAT
resolver
amino_acid_sequence
MIWKRSAVLRFYSVCGLLLLGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQALTLTCESKGKPLPEPVLWTKDGAELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDVPNTLLPTTIIPSLTTAPVTTTVAITTSPSTSASSSSRRDPNSLAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQVNAEEKKEYFI
uniprot
proteins
function
FUNCTION: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
47528
uniprot
proteins
post_translational_modification
PTM: Glycosylation at Asn-51 reduces adhesive binding. {ECO:0000250}.
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24090084
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BLQ9}; Single-pass type I membrane protein {ECO:0000255}. Synapse {ECO:0000250|UniProtKB:Q8N3J6}. Cell projection, axon {ECO:0000250|UniProtKB:Q8N3J6}. Note=Found in the axoplasm of myelinated axons. {ECO:0000250|UniProtKB:Q8N3J6}.
uniprot
proteins
transmembrane_region
TRANSMEM 368..388; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins