Gnmt
entrez
25134
canonical
uniprot
P13255
canonical
ensembl
ENSRNOG00000016349
resolver
ensembl
ENSRNOG00055008666
resolver
ensembl
ENSRNOG00060023668
resolver
ensembl
ENSRNOG00065026940
resolver
ensp
ENSRNOP00000022307
resolver
ensp
ENSRNOP00000067671
resolver
ensp
ENSRNOP00055011702
resolver
ensp
ENSRNOP00060033940
resolver
ensp
ENSRNOP00065038109
resolver
enst
ENSRNOT00000072812
resolver
enst
ENSRNOT00055014634
resolver
enst
ENSRNOT00060041013
resolver
enst
ENSRNOT00065046482
resolver
genesymbol
Gnmt
resolver
genesymbol_syn
Fbp-cII
resolver
uniprot
M0RDH0
resolver
uniprot_entry
GNMT_RAT
resolver
uniprot_entry
M0RDH0_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 5-methyltetrahydrofolate monoglutamate and by 5-methyltetrahydrofolate pentaglutamate, inhibition is much more effective by the pentaglutamate form than by the monoglutamate form (PubMed:3838667). Two molecules of 5-methyltetrahydrofolate are bound per tetramer. The binding sites are localized between subunits. Inhibitor binding may preclude movements of the polypeptide chain that are necessary for enzyme activity. {ECO:0000269|PubMed:17158459, ECO:0000269|PubMed:22037183, ECO:0000269|PubMed:3838667}.
uniprot
proteins
amino_acid_sequence
MVDSVYRTRSLGVAAEGIPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCHRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRKEPAFDKWVIEEANWLTLDKDVPAGDGFDAVICLGNSFAHLPDSKGDQSEHRLALKNIASMVRPGGLLVIDHRNYDYILSTGCAPPGKNIYYKSDLTKDITTSVLTVNNKAHMVTLDYTVQVPGAGRDGAPGFSKFRLSYYPHCLASFTELVQEAFGGRCQHSVLGDFKPYRPGQAYVPCYFIHVLKKTG
uniprot
proteins
ec_number
2.1.1.20
uniprot
proteins
function
FUNCTION: Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine. {ECO:0000250|UniProtKB:Q14749}.
uniprot
proteins
mass_dalton
32549
uniprot
proteins
mutagenesis
MUTAGEN 34; /note="Y->F: Reduces affinity for glycine."; /evidence="ECO:0000269|PubMed:12859184"; MUTAGEN 176; /note="R->K: Strongly reduced affinity for glycine."; /evidence="ECO:0000269|PubMed:12859184"; MUTAGEN 221; /note="Y->F: Reduces affinity for glycine."; /evidence="ECO:0000269|PubMed:12859184
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Glycine N-methyltransferase family
uniprot
proteins
pubmed
10756111
uniprot
proteins
pubmed
12859184
uniprot
proteins
pubmed
17158459
uniprot
proteins
pubmed
22037183
uniprot
proteins
pubmed
2822402
uniprot
proteins
pubmed
3838667
uniprot
proteins
pubmed
6587377
uniprot
proteins
pubmed
8810903
uniprot
proteins
pubmed
9655336
uniprot
proteins
sequence_length
293
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:6587377}.
uniprot
proteins