Lat
entrez
81511
canonical
uniprot
O70601
canonical
ensembl
ENSRNOG00000017429
resolver
ensembl
ENSRNOG00055030999
resolver
ensembl
ENSRNOG00060027857
resolver
ensembl
ENSRNOG00065016276
resolver
ensp
ENSRNOP00000023563
resolver
ensp
ENSRNOP00000095642
resolver
ensp
ENSRNOP00055044506
resolver
ensp
ENSRNOP00060040347
resolver
ensp
ENSRNOP00065021303
resolver
enst
ENSRNOT00000023563
resolver
enst
ENSRNOT00000110518
resolver
enst
ENSRNOT00055053787
resolver
enst
ENSRNOT00060048432
resolver
enst
ENSRNOT00065027101
resolver
genesymbol
Lat
resolver
uniprot
A0A8I6ARU8
resolver
uniprot_entry
A0A8I6ARU8_RAT
resolver
uniprot_entry
LAT_RAT
resolver
amino_acid_sequence
MEADALSPVELGLLLLPFVVMLLAALCVRCRELPASYDSASTESLYPRSILIKPPQITVPRTPATSYPLVTSFPPLRQPDLLPIPRSPQPLGGSHRMPSSRQNSDDANSVASYENQEPARKNVDEDEDEDDYPEGYLVVLPDSSPAAVPVVSSAPVPSNPDLGDSAFSMESCEDYVNVPESEESAEASLDGSREYVNVSQDAQPVIRAELASVTSQEVEDEEEEDVDGEEAPDYENLQELN
uniprot
proteins
function
FUNCTION: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
26193
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ (By similarity). {ECO:0000250}.; PTM: Palmitoylation of Cys-27 and Cys-30 is required for raft targeting and efficient phosphorylation. {ECO:0000250}.; PTM: Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes. {ECO:0000250|UniProtKB:O43561}.; PTM: 'Lys-63'-linked ubiquitinated by TRAF6. {ECO:0000250|UniProtKB:O43561}.
uniprot
proteins
pubmed
16160011
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9529333
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Note=Present in lipid rafts. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..28; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins