Hcar2
entrez
353250
canonical
uniprot
Q80Z39
canonical
ensembl
ENSRNOG00000071408
resolver
ensembl
ENSRNOG00055015968
resolver
ensembl
ENSRNOG00060003186
resolver
ensembl
ENSRNOG00065007951
resolver
ensp
ENSRNOP00000098813
resolver
ensp
ENSRNOP00055021878
resolver
ensp
ENSRNOP00060003876
resolver
ensp
ENSRNOP00065009239
resolver
enst
ENSRNOT00000156924
resolver
enst
ENSRNOT00055027138
resolver
enst
ENSRNOT00060005240
resolver
enst
ENSRNOT00065012542
resolver
genesymbol
Hcar2
resolver
genesymbol_syn
Gpr109
resolver
genesymbol_syn
Gpr109a
resolver
genesymbol_syn
Gpr109b
resolver
genesymbol_syn
Niacr1
resolver
genesymbol_syn
Pumag
resolver
uniprot_entry
HCAR2_RAT
resolver
amino_acid_sequence
MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSICYTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVICFLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR
uniprot
proteins
function
FUNCTION: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. {ECO:0000269|PubMed:12522134, ECO:0000269|PubMed:12646212, ECO:0000269|PubMed:19141678}.
uniprot
proteins
mass_dalton
41459
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12522134
uniprot
proteins
pubmed
12646212
uniprot
proteins
pubmed
19141678
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 61..81; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 99..119; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 141..161; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 227..247; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 271..291; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins