ACKR2
entrez
1238
canonical
uniprot
O00590
canonical
ensembl
ENSG00000144648
resolver
ensp
ENSP00000396150
resolver
ensp
ENSP00000416996
resolver
ensp
ENSP00000535572
resolver
ensp
ENSP00000535573
resolver
ensp
ENSP00000535574
resolver
ensp
ENSP00000535575
resolver
ensp
ENSP00000535576
resolver
ensp
ENSP00000535577
resolver
ensp
ENSP00000535578
resolver
ensp
ENSP00000535579
resolver
ensp
ENSP00000535580
resolver
ensp
ENSP00000535581
resolver
ensp
ENSP00000535582
resolver
ensp
ENSP00000535583
resolver
ensp
ENSP00000583538
resolver
ensp
ENSP00000617457
resolver
enst
ENST00000422265
resolver
enst
ENST00000442925
resolver
enst
ENST00000865513
resolver
enst
ENST00000865514
resolver
enst
ENST00000865515
resolver
enst
ENST00000865516
resolver
enst
ENST00000865517
resolver
enst
ENST00000865518
resolver
enst
ENST00000865519
resolver
enst
ENST00000865520
resolver
enst
ENST00000865521
resolver
enst
ENST00000865522
resolver
enst
ENST00000865523
resolver
enst
ENST00000865524
resolver
enst
ENST00000913479
resolver
enst
ENST00000947398
resolver
genesymbol
ACKR2
resolver
genesymbol_syn
CCBP2
resolver
genesymbol_syn
CCR10
resolver
genesymbol_syn
CMKBR9
resolver
genesymbol_syn
D6
resolver
hgnc
HGNC:1565
resolver
uniprot
B2R8Y8
resolver
uniprot
O00537
resolver
uniprot
Q53YA1
resolver
uniprot
Q86UN9
resolver
uniprot
Q96A02
resolver
uniprot_entry
ACKR2_HUMAN
resolver
uniprot_sec
B2R8Y8
resolver
uniprot_sec
O00537
resolver
uniprot_sec
Q53YA1
resolver
uniprot_sec
Q86UN9
resolver
uniprot_sec
Q96A02
resolver
amino_acid_sequence
MAATASPQPLATEDADSENSSFYYYDYLDEVAFMLCRKDAVVSFGKVFLPVFYSLIFVLGLSGNLLLLMVLLRYVPRRRMVEIYLLNLAISNLLFLVTLPFWGISVAWHWVFGSFLCKMVSTLYTINFYSGIFFISCMSLDKYLEIVHAQPYHRLRTRAKSLLLATIVWAVSLAVSIPDMVFVQTHENPKGVWNCHADFGGHGTIWKLFLRFQQNLLGFLLPLLAMIFFYSRIGCVLVRLRPAGQGRALKIAAALVVAFFVLWFPYNLTLFLHTLLDLQVFGNCEVSQHLDYALQVTESIAFLHCCFSPILYAFSSHRFRQYLKAFLAAVLGWHLAPGTAQASLSSCSESSILTAQEEMTGMNDLGERQSENYPNKEDVGNKSA
uniprot
proteins
function
FUNCTION: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis (PubMed:18201974, PubMed:20373092, PubMed:23479571). Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor (PubMed:18201974, PubMed:20373092, PubMed:23479571). Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3 (PubMed:18201974, PubMed:20373092, PubMed:23479571). Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway (PubMed:23633677). Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses (PubMed:23479571). Plays a major role in the immune silencing of macrophages during the resolution of inflammation (By similarity). Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs (PubMed:23479571). {ECO:0000250|UniProtKB:O08707, ECO:0000269|PubMed:18201974, ECO:0000269|PubMed:23479571, ECO:0000269|PubMed:23633677, ECO:0000303|PubMed:20373092}.
uniprot
proteins
mass_dalton
43443
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues in the C-terminal cytoplasmic tail. {ECO:0000269|PubMed:18201974}.
uniprot
proteins
protein_family
Atypical chemokine receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11238036
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18201974
uniprot
proteins
pubmed
20373092
uniprot
proteins
pubmed
22651933
uniprot
proteins
pubmed
22698181
uniprot
proteins
pubmed
22939232
uniprot
proteins
pubmed
23125030
uniprot
proteins
pubmed
23356288
uniprot
proteins
pubmed
23479571
uniprot
proteins
pubmed
23633677
uniprot
proteins
pubmed
38175886
uniprot
proteins
pubmed
9364936
uniprot
proteins
pubmed
9405404
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:18201974}. Recycling endosome {ECO:0000269|PubMed:18201974}. Cell membrane {ECO:0000269|PubMed:18201974, ECO:0000269|PubMed:23633677}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits (PubMed:18201974). Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (PubMed:18201974). {ECO:0000269|PubMed:18201974}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..71; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 119..140; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 218..238; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 251..271; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 294..314; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins