Mnat1
entrez
17420
canonical
uniprot
P51949
canonical
ensembl
ENSMUSG00000021103
resolver
ensp
ENSMUSP00000021523
resolver
enst
ENSMUST00000021523
resolver
genesymbol
Mnat1
resolver
genesymbol_syn
Mat1
resolver
uniprot
Q14BS9
resolver
uniprot
Q3TZP0
resolver
uniprot
Q9D8A0
resolver
uniprot
Q9D8D2
resolver
uniprot_entry
MAT1_MOUSE
resolver
uniprot_sec
Q14BS9
resolver
uniprot_sec
Q3TZP0
resolver
uniprot_sec
Q9D8A0
resolver
uniprot_sec
Q9D8D2
resolver
amino_acid_sequence
MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRVQLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLENTKKKMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQEHEQRRLFIQKEEELQQALKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPRSMKPVTFSTGIKMGQQISLAPIQKLEEALYEYQPLQIETCGPQVPEQELLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPR
uniprot
proteins
function
FUNCTION: Component of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalyzing the activating threonine phosphorylation of CDKs (By similarity). Binds and activates CDK7, the catalytic subunit of CAK (By similarity). CAK activates major mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, and plays a key role in regulating cell cycle progression (By similarity). CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts (By similarity). Involved in cell cycle control and in RNA transcription by RNA polymerase II (By similarity). {ECO:0000250|UniProtKB:P51948}.
uniprot
proteins
mass_dalton
35848
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7553872
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins