Lrrc14
entrez
223664
canonical
uniprot
Q8VC16
canonical
ensembl
ENSMUSG00000033728
resolver
ensp
ENSMUSP00000049466
resolver
ensp
ENSMUSP00000114921
resolver
ensp
ENSMUSP00000115446
resolver
ensp
ENSMUSP00000121982
resolver
ensp
ENSMUSP00000263926
resolver
ensp
ENSMUSP00000263927
resolver
ensp
ENSMUSP00000263929
resolver
ensp
ENSMUSP00000263939
resolver
ensp
ENSMUSP00000263945
resolver
ensp
ENSMUSP00000263947
resolver
ensp
ENSMUSP00000263948
resolver
enst
ENSMUST00000036423
resolver
enst
ENSMUST00000127208
resolver
enst
ENSMUST00000137649
resolver
enst
ENSMUST00000155735
resolver
genesymbol
Lrrc14
resolver
genesymbol_syn
Kiaa0014
resolver
uniprot
Q6A0E7
resolver
uniprot
Q80WK3
resolver
uniprot_entry
LRC14_MOUSE
resolver
uniprot_sec
Q6A0E7
resolver
uniprot_sec
Q80WK3
resolver
amino_acid_sequence
MHTLVFLSTRQVLQCQPAACQALPLLPRELFPLLFKVAFMDKKTLVLRELVHTWPFPLLSFQQLLQECAHCSRALLQERLSTESMQAVILGLTARIHTQETEAGTQPLCRKHALRVLDMTGLLDDGVEQDPETMSMWDCTAAVARTCIAQQQGGTAEPGLSPVPVEIRVDLRVNRASYTFLREALQSSVASPLRLCCRDLRAEDLPMRNTVALLQLLDAGCLRRIDLRFNNLGLRGLSVIIPHVARFQHLASLRLHYVHGDSRQPSVDGEDNFRYFLAQMGRFMCLRELSMGSSLLSGRLDQLLSTLQRPLESLELAFCALLPEDLRFLAQSSHAAHLKKLDLSGNDLSGNQLTPFQGLLQAVATTLLHLELTECQLADAQLLATLPTLTRCASLRYLGLYGNPLSMAGLKELLRDSVVQAELRTVVHPFPVDCYEGLPWPPPASVLLEASINEEKFARVEAELHQLLLASGRAHVLWTTDIYGRLAADYFSL
uniprot
proteins
function
FUNCTION: Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB. {ECO:0000250|UniProtKB:Q15048}.
uniprot
proteins
mass_dalton
54969
uniprot
proteins
protein_family
LRRC14 subfamily
uniprot
proteins
protein_family
PRAME family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27426725
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15048}.
uniprot
proteins