Adora3
entrez
100911796
canonical
uniprot
P28647
canonical
ensembl
ENSRNOG00000015788
resolver
ensp
ENSRNOP00000021236
resolver
genesymbol
Adora3
resolver
uniprot
Q63792
resolver
uniprot_entry
AA3R_RAT
resolver
uniprot_sec
Q63792
resolver
amino_acid_sequence
MKANNTTTSALWLQITYITMEAAIGLCAVVGNMLVIWVVKLNRTLRTTTFYFIVSLALADIAVGVLVIPLAIAVSLEVQMHFYACLFMSCVLLVFTHASIMSLLAIAVDRYLRVKLTVRYRTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKVTLELSQNSSTLSCHFRSVVGLDYMVFFSFITWILIPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFNVKIPEIAMCLGILLSHANSMMNPIVYACKIKKFKETYFVILRACRLCQTSDSLDSNLEQTTE
uniprot
proteins
function
FUNCTION: G protein-coupled receptor (GPCR) for adenosine that plays significant roles in various physiological processes including immune regulation, cardioprotection and neuroprotection (PubMed:1323836). Also acts as a receptor for adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification, which are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs): activated by N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A) (PubMed:33472058). Preferentially couples to the inhibitory G protein (Gi), leading to the suppression of adenylate cyclase activity and a reduction in intracellular cyclic AMP levels (By similarity). Upon adenosine binding, mediates cardioprotection in cardiomyocytes through anti-apoptotic effects primarily via the ERK1/2 pathway as well as the PI3K pathway (PubMed:16005018). In the central nervous system, participates in the modulation of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus (PubMed:11278110). In lung mast cells, receptor activation contributes to the type I allergic response by facilitating mast cell degranulation and histamine release (PubMed:33472058). Highly expressed in inflammatory cells such as neutrophils and mast cells, inhibits neutrophil degranulation and reduces superoxide production, thereby modulating inflammatory responses (By similarity). {ECO:0000250|UniProtKB:P0DMS8, ECO:0000250|UniProtKB:Q61618, ECO:0000269|PubMed:11278110, ECO:0000269|PubMed:1323836, ECO:0000269|PubMed:16005018, ECO:0000269|PubMed:33472058}.
uniprot
proteins
mass_dalton
36629
uniprot
proteins
mutagenesis
MUTAGEN 302..305; /note="CRLC->ARLA: Promotes agonist-independent phosphorylation."; /evidence="ECO:0000269|PubMed:10692494"; MUTAGEN 307; /note="T->A: Small decrease in agonist-stimulated phosphorylation."; /evidence="ECO:0000269|PubMed:10692494"; MUTAGEN 318; /note="T->A,E: Strong decrease in agonist-stimulated phosphorylation."; /evidence="ECO:0000269|PubMed:10692494"; MUTAGEN 319; /note="T->A: 50% decrease in agonist-stimulated phosphorylation."; /evidence="ECO:0000269|PubMed:10692494
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Thr-318 and Thr-319 may be crucial for rapid desensitization. Phosphorylation on Thr-318 may be necessary for phosphorylation on Thr-319 to occur. {ECO:0000269|PubMed:10692494}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10692494
uniprot
proteins
pubmed
11278110
uniprot
proteins
pubmed
1323836
uniprot
proteins
pubmed
16005018
uniprot
proteins
pubmed
1647979
uniprot
proteins
pubmed
33472058
uniprot
proteins
pubmed
8612733
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q28309}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..40; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P0DMS8"; TRANSMEM 49..71; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P0DMS8"; TRANSMEM 86..108; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P0DMS8"; TRANSMEM 129..151; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P0DMS8"; TRANSMEM 174..199; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P0DMS8"; TRANSMEM 231..256; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P0DMS8"; TRANSMEM 265..286; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P0DMS8
uniprot
proteins