MRPL32
entrez
64983
canonical
uniprot
Q9BYC8
canonical
ensembl
ENSG00000106591
resolver
ensp
ENSP00000223324
resolver
enst
ENST00000223324
resolver
genesymbol
MRPL32
resolver
hgnc
HGNC:14035
resolver
uniprot
A4D1V4
resolver
uniprot
Q96Q68
resolver
uniprot
Q9P098
resolver
uniprot_entry
A4D1V4_HUMAN
resolver
uniprot_entry
RM32_HUMAN
resolver
uniprot_sec
Q96Q68
resolver
uniprot_sec
Q9P098
resolver
amino_acid_sequence
MALAMLVLVVSPWSAARGVLRNYWERLLRKLPQSRPGFPSPPWGPALAVQGPAMFTEPANDTSGSKENSSLLDSIFWMAAPKNRRTIEVNRCRRRNPQKLIKVKNNIDVCPECGHLKQKHVLCAYCYEKVCKETAEIRRQIGKQEGGPFKAPTIETVVLYTGETPSEQDQGKRIIERDRKRPSWFTQN
uniprot
proteins
function
FUNCTION: Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042). The mitochondrial ribosome (mitoribosome) is a large ribonucleoprotein complex responsible for the synthesis of proteins inside mitochondria (PubMed:25278503, PubMed:25838379, PubMed:28892042). {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
uniprot
proteins
mass_dalton
21405
uniprot
proteins
post_translational_modification
PTM: MRPL32 precursor is processed by the m-AAA protease (composed of AFG3L2 and SPG7), which cleaves the N-terminal transit peptide (PubMed:29932645). Cleavage by the m-AAA protease takes place prior to assembly into the large subunit, an essential step for mitochondrial ribosome (mitoribosome) assembly (PubMed:29932645). Proper processing by the m-AAA protease is dependent on the zinc-binding region within the tightly folded C-terminal domain of MRPL32: zinc-dependent folding halts degradation initiated from the N-terminus and triggers the release of mature MRPL32 (By similarity). {ECO:0000250|UniProtKB:P25348, ECO:0000269|PubMed:29932645}.
uniprot
proteins
protein_family
Bacterial ribosomal protein bL32 family
uniprot
proteins
pubmed
11279069
uniprot
proteins
pubmed
11543634
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25278503
uniprot
proteins
pubmed
25838379
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28892042
uniprot
proteins
pubmed
29932645
uniprot
proteins
pubmed
35177605
uniprot
proteins
sequence_length
188
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
uniprot
proteins