Phlda3
entrez
27280
canonical
uniprot
Q9WV95
canonical
ensembl
ENSMUSG00000041801
resolver
ensp
ENSMUSP00000040614
resolver
enst
ENSMUST00000038945
resolver
genesymbol
Phlda3
resolver
genesymbol_syn
Tih1
resolver
uniprot_entry
PHLA3_MOUSE
resolver
amino_acid_sequence
MTAAATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKAVECVESTGRHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQSLGTGTLVS
uniprot
proteins
function
FUNCTION: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
13719
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="K->A: Impairs the ability to resucue growth in cdc25ts mutant yeasts."; /evidence="ECO:0000269|PubMed:12374806"; MUTAGEN 28; /note="R->A: Impairs the ability to resucue growth in cdc25ts mutant yeasts."; /evidence="ECO:0000269|PubMed:12374806
uniprot
proteins
protein_family
PHLDA3 family
uniprot
proteins
pubmed
10594239
uniprot
proteins
pubmed
12032310
uniprot
proteins
pubmed
12374806
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
125
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12374806}. Membrane {ECO:0000269|PubMed:12374806}; Peripheral membrane protein {ECO:0000269|PubMed:12374806}.
uniprot
proteins