Eif4a1
entrez
13681
canonical
uniprot
P60843
canonical
ensembl
ENSMUSG00000059796
resolver
ensp
ENSMUSP00000127034
resolver
enst
ENSMUST00000163666
resolver
genesymbol
Eif4a1
resolver
genesymbol_syn
Ddx2a
resolver
genesymbol_syn
Eif4a
resolver
uniprot
P04765
resolver
uniprot
Q3TLL6
resolver
uniprot
Q5F2A7
resolver
uniprot
Q61516
resolver
uniprot_entry
IF4A1_MOUSE
resolver
uniprot_entry
Q3TLL6_MOUSE
resolver
uniprot_entry
Q5F2A7_MOUSE
resolver
uniprot_sec
P04765
resolver
uniprot_sec
Q61516
resolver
amino_acid_sequence
MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (By similarity). {ECO:0000250|UniProtKB:P60842}.
uniprot
proteins
mass_dalton
46154
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
protein_family
eIF4A subfamily
uniprot
proteins
pubmed
1378397
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
3215517
uniprot
proteins
pubmed
3840589
uniprot
proteins
pubmed
39349455
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P60842}. Cell membrane {ECO:0000250|UniProtKB:P60842}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P60842}. Note=Colocalizes with PKP1 in stress granules following arsenate or hydrogen peroxide treatment. {ECO:0000250|UniProtKB:P60842}.
uniprot
proteins