MGST3
entrez
4259
canonical
uniprot
O14880
canonical
ensembl
ENSG00000143198
resolver
ensp
ENSP00000356858
resolver
ensp
ENSP00000356859
resolver
ensp
ENSP00000356860
resolver
ensp
ENSP00000356864
resolver
ensp
ENSP00000487151
resolver
ensp
ENSP00000525246
resolver
ensp
ENSP00000525247
resolver
ensp
ENSP00000525248
resolver
ensp
ENSP00000525249
resolver
ensp
ENSP00000525251
resolver
ensp
ENSP00000525252
resolver
ensp
ENSP00000525253
resolver
ensp
ENSP00000525254
resolver
ensp
ENSP00000525255
resolver
ensp
ENSP00000525256
resolver
ensp
ENSP00000525257
resolver
ensp
ENSP00000592073
resolver
ensp
ENSP00000592076
resolver
ensp
ENSP00000592078
resolver
ensp
ENSP00000592079
resolver
ensp
ENSP00000592080
resolver
ensp
ENSP00000592081
resolver
ensp
ENSP00000592082
resolver
ensp
ENSP00000639072
resolver
ensp
ENSP00000639073
resolver
ensp
ENSP00000639074
resolver
ensp
ENSP00000639075
resolver
ensp
ENSP00000639076
resolver
ensp
ENSP00000639077
resolver
ensp
ENSP00000639078
resolver
enst
ENST00000367883
resolver
enst
ENST00000367884
resolver
enst
ENST00000367885
resolver
enst
ENST00000367889
resolver
enst
ENST00000627653
resolver
enst
ENST00000855187
resolver
enst
ENST00000855188
resolver
enst
ENST00000855189
resolver
enst
ENST00000855190
resolver
enst
ENST00000855192
resolver
enst
ENST00000855193
resolver
enst
ENST00000855194
resolver
enst
ENST00000855195
resolver
enst
ENST00000855196
resolver
enst
ENST00000855197
resolver
enst
ENST00000855198
resolver
enst
ENST00000922014
resolver
enst
ENST00000922017
resolver
enst
ENST00000922019
resolver
enst
ENST00000922020
resolver
enst
ENST00000922021
resolver
enst
ENST00000922022
resolver
enst
ENST00000922023
resolver
enst
ENST00000969013
resolver
enst
ENST00000969014
resolver
enst
ENST00000969015
resolver
enst
ENST00000969016
resolver
enst
ENST00000969017
resolver
enst
ENST00000969018
resolver
enst
ENST00000969019
resolver
genesymbol
MGST3
resolver
hgnc
HGNC:7064
resolver
uniprot
B2R592
resolver
uniprot
Q5VV89
resolver
uniprot
Q6ICN4
resolver
uniprot_entry
MGST3_HUMAN
resolver
uniprot_entry
Q5VV89_HUMAN
resolver
uniprot_sec
B2R592
resolver
uniprot_sec
Q6ICN4
resolver
amino_acid_sequence
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRAHQNTLEVYPPFLFFLAVGGVYHPRIASGLGLAWIVGRVLYAYGYYTGEPSKRSRGALGSIALLGLVGTTVCSAFQHLGWVKSGLGSGPKCCH
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
ec_number
2.5.1.-
uniprot
proteins
ec_number
4.4.1.20
uniprot
proteins
function
FUNCTION: Displays both glutathione S-transferase and glutathione peroxidase activities toward oxyeicosanoids, as part of cellular detoxification as well as synthesis of bioactive metabolites (PubMed:36370807, PubMed:9278457). Catalyzes conjugate addition of reduced glutathione to the alpha, beta-unsaturated C=C carbonyl group of eisosanoids such as leukotriene A4 and 15-deoxy-Delta12,14-prostaglandin J2 to form GSH adducts relevant to the inflammatory response (PubMed:36370807, PubMed:9278457). Catalyzes glutathione-dependent reduction of eicosanoid peroxides to yield the corresponding eicosanoid hydroxides (PubMed:9278457). {ECO:0000269|PubMed:36370807, ECO:0000269|PubMed:9278457}.
uniprot
proteins
mass_dalton
16516
uniprot
proteins
mutagenesis
MUTAGEN 150; /note="C->S: Abolishes S-acylation; when associated with S-151."; /evidence="ECO:0000269|PubMed:21044946"; MUTAGEN 151; /note="C->S: Abolishes S-acylation; when associated with S-150."; /evidence="ECO:0000269|PubMed:21044946
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; leukotriene C4 biosynthesis. {ECO:0000305|PubMed:9278457}.; PATHWAY: Lipid metabolism; arachidonate metabolism. {ECO:0000305|PubMed:9278457}.
uniprot
proteins
protein_family
MAPEG family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21044946
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27184847
uniprot
proteins
pubmed
36370807
uniprot
proteins
pubmed
9278457
uniprot
proteins
sequence_length
152
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:27184847}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins