Oxr1
entrez
170719
canonical
uniprot
Q4KMM3
canonical
ensembl
ENSMUSG00000022307
resolver
ensp
ENSMUSP00000022918
resolver
ensp
ENSMUSP00000087553
resolver
ensp
ENSMUSP00000105926
resolver
ensp
ENSMUSP00000126266
resolver
ensp
ENSMUSP00000130456
resolver
ensp
ENSMUSP00000155161
resolver
ensp
ENSMUSP00000155237
resolver
ensp
ENSMUSP00000155424
resolver
ensp
ENSMUSP00000202714
resolver
enst
ENSMUST00000166917
resolver
enst
ENSMUST00000170127
resolver
genesymbol
Oxr1
resolver
genesymbol_syn
C7
resolver
genesymbol_syn
Gm1238
resolver
uniprot
B1H3M0
resolver
uniprot
E9Q0A7
resolver
uniprot
F6R3R8
resolver
uniprot
Q5FWW1
resolver
uniprot
Q99L06
resolver
uniprot
Q99MK1
resolver
uniprot
Q99MP4
resolver
uniprot_entry
B1H3M0_MOUSE
resolver
uniprot_entry
E9Q0A7_MOUSE
resolver
uniprot_entry
F6R3R8_MOUSE
resolver
uniprot_entry
OXR1_MOUSE
resolver
uniprot_sec
Q5FWW1
resolver
uniprot_sec
Q99L06
resolver
uniprot_sec
Q99MK1
resolver
uniprot_sec
Q99MP4
resolver
amino_acid_sequence
MSVSNLSWLKKKSQSVDITAPGFNPLGGAGKQAPQASKPPAPKTPIIEEEQNNSANTQKHPSRKSELKRFYTIDTGQKKTLDKKDGRRMSFQKPKGTIEYTVESRDSLNSIALKFDTTPNELVQLNKLFSRAVVTGQVLYVPDPEYVSSVESSPSLSPVSPLSPTSSEAEFDKTTTPDVAHPKEAPPASTVSGIRPARVVSSTSEEEEAFTEKFLKINCKYITIGKGTVSGVLLVTPNNIMFDPHKTDPLVQENGCEEYGIMCPMEEVMSAAMYKEILDSKIKESLPIELDQLSGRGSCHSKKATGVSAEDADPRARDQGNDSASTAPRSTEESLSEDAFTESELSPIREELLSSEPRQEKSSDASSESVQTVSQMEVQSLTATSEAANVPDRTSSNPGALSHETGLSGLETATKGGDKATESLQEVSGPKEQSTEVKGQDNQDSSHQESSLQQEAGEDSVSSGETVELKEKPAVLKDQQGQELKRDSETEVEELRKLWKTHSMQQAKQQRDTIQQVSQRESKHSSAAADAHGEGSSLLKEKRRHRLHKFLCLRVGKPMRKTFVSQASATMQQYAQRDKKHEYWFAVPQERTDHLYAFFIQWSPEIYAEDSGEYTREPGFIVVKKMDESEANEAPAGEAAAREWEVVSVAEYHRRIDALNTEELRTLCRRLQITTREDINSKQVAPAKADLEPESFRPNLSDPSELLLPDQIEKLTKHLPPRTIGYPWTLVYGTGKHGTSLKTLYRTMTGLDTPVLMVIKDSDGQVFGALASEPFKVSDGFYGTGETFVFTFCPEFEVFKWTGDNMFFIKGDMDSLAFGGGGGEFALWLDGDLYHGRSHSCKTFGNHTLSKKEDFFIQDIEIWAFE
uniprot
proteins
function
FUNCTION: Inhibits the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (By similarity). Protects the Golgi apparatus lumen from excess acidification by inhibiting V-ATPase ATP hydrolytic activity through interaction with V-ATPase catalytic subunit ATP6V1A, maintaining optimal conditions for glycosylation enzymes (PubMed:40445757). Involved in protection from oxidative damage (PubMed:22028674, PubMed:26668325). Protects neuronal cells from oxidative stress (PubMed:22028674, PubMed:26668325). {ECO:0000250|UniProtKB:Q8N573, ECO:0000269|PubMed:22028674, ECO:0000269|PubMed:26668325, ECO:0000269|PubMed:40445757}.
uniprot
proteins
mass_dalton
95912
uniprot
proteins
mutagenesis
MUTAGEN 773; /note="E->A: Abolishes neuroprotective activity. Increases levels of S-nitrosylated proteins in neurons."; /evidence="ECO:0000269|PubMed:26668325"; MUTAGEN 793; /note="C->A: Does not affect oxidation."; /evidence="ECO:0000269|PubMed:22028674"; MUTAGEN 841; /note="C->A: Reduces oxidation."; /evidence="ECO:0000269|PubMed:22028674
uniprot
proteins
post_translational_modification
PTM: Undergoes oxidation following oxidative stress induced by hydrogen peroxide. {ECO:0000269|PubMed:22028674}.
uniprot
proteins
protein_family
OXR1 family
uniprot
proteins
pubmed
11237729
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22028674
uniprot
proteins
pubmed
26668325
uniprot
proteins
pubmed
34811399
uniprot
proteins
pubmed
40445757
uniprot
proteins
sequence_length
866
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22028674}. Nucleus, nucleolus {ECO:0000269|PubMed:11237729}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:40445757}; Peripheral membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:40445757}; Peripheral membrane protein {ECO:0000305}. Note=Detected in mitochondria in neuronal cells (PubMed:22028674). Has also been detected in the nucleolus in fibroblasts and myoblasts (PubMed:11237729). Recruited to the cis-Golgi network and trans-Golgi network membranes in a Rab-dependent manner (PubMed:40445757). {ECO:0000269|PubMed:11237729, ECO:0000269|PubMed:22028674, ECO:0000269|PubMed:40445757}.
uniprot
proteins