RIOK3
entrez
8780
canonical
uniprot
O14730
canonical
ensembl
ENSG00000101782
resolver
ensp
ENSP00000341874
resolver
ensp
ENSP00000463660
resolver
ensp
ENSP00000655933
resolver
enst
ENST00000581585
resolver
genesymbol
RIOK3
resolver
genesymbol_syn
SUDD
resolver
hgnc
HGNC:11451
resolver
uniprot
B0YJ89
resolver
uniprot
B4E1Q4
resolver
uniprot
J3QLQ4
resolver
uniprot
Q8IXN9
resolver
uniprot_entry
B0YJ89_HUMAN
resolver
uniprot_entry
B4E1Q4_HUMAN
resolver
uniprot_entry
J3QLQ4_HUMAN
resolver
uniprot_entry
RIOK3_HUMAN
resolver
uniprot_sec
Q8IXN9
resolver
amino_acid_sequence
MDLVGVASPEPGTAAAWGPSKCPWAIPQNTISCSLADVMSEQLAKELQLEEEAAVFPEVAVAEGPFITGENIDTSSDLMLAQMLQMEYDREYDAQLRREEKKFNGDSKVSISFENYRKVHPYEDSDSSEDEVDWQDTRDDPYRPAKPVPTPKKGFIGKGKDITTKHDEVVCGRKNTARMENFAPEFQVGDGIGMDLKLSNHVFNALKQHAYSEERRSARLHEKKEHSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSMEDEKEDSKVIPTECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMHNLARMQRAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKLNSEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNMLWHAGKVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVKEALSERELFNAVSGLNITADNEADFLAEIEALEKMNEDHVQKNGRKAASFLKDDGDPPLLYDE
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in a ribosome quality control that takes place when ribosomes have stalled, leading to 18S non-functional rRNA decay and degradation of the 40S ribosomal subunit (PubMed:39947182, PubMed:39947183, PubMed:40022732). Acts downstream of RNF10: specifically recognizes and binds RPS2/us5 and RPS3/us3 monoubiquitinated by RNF10, promoting degradation of the 40S ribosomal subunit in a kinase-dependent manner (PubMed:39947182, PubMed:39947183, PubMed:40022732). The RNF10-RIOK3 ribosome quality control takes place in response to ribosome subunit imbalance or downstream the EIF2AK4/GCN2-mediated integrated stress response (ISR) (PubMed:39947182, PubMed:39947183, PubMed:40022732). Also involved in regulation of type I interferon (IFN)-dependent immune response, possibly by acting as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappa-B signaling pathway (PubMed:19557502). {ECO:0000269|PubMed:19557502, ECO:0000269|PubMed:24807708, ECO:0000269|PubMed:25865883, ECO:0000269|PubMed:39947182, ECO:0000269|PubMed:39947183, ECO:0000269|PubMed:40022732}.
uniprot
proteins
mass_dalton
59093
uniprot
proteins
mutagenesis
MUTAGEN 60..95; /note="Missing: Abolished ability to recognize and bind monoubiquitinated RPS2/us5 and RPS3/us3."; /evidence="ECO:0000269|PubMed:39947183"; MUTAGEN 290; /note="K->A: Decreases autophosphorylation (in vitro); abolishes inhibition of TNF-induced NF-kappaB activation; no effect on interaction with IRF3; fails to activate IFN-beta promoter and IRF3 phosphorylation. Decreased serine/threonine-protein kinase activity, leading to impaired ribosome quality control in response to ribosome stalling."; /evidence="ECO:0000269|PubMed:19557502, ECO:0000269|PubMed:24807708, ECO:0000269|PubMed:39947183, ECO:0000269|PubMed:40022732"; MUTAGEN 406; /note="D->A: Abolished serine/threonine-protein kinase activity, leading to impaired ribosome quality control in response to ribosome stalling."; /evidence="ECO:0000269|PubMed:39947182, ECO:0000269|PubMed:39947183, ECO:0000269|PubMed:40022732
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated (in vitro). {ECO:0000269|PubMed:19557502}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
RIO-type Ser/Thr kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19557502
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22072790
uniprot
proteins
pubmed
22418843
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24807708
uniprot
proteins
pubmed
25865883
uniprot
proteins
pubmed
39947182
uniprot
proteins
pubmed
39947183
uniprot
proteins
pubmed
40022732
uniprot
proteins
pubmed
9602165
uniprot
proteins
sequence_length
519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22418843, ECO:0000269|PubMed:39947182, ECO:0000269|PubMed:39947183}.
uniprot
proteins