Grik2
entrez
14806
canonical
uniprot
P39087
canonical
ensembl
ENSMUSG00000056073
resolver
ensp
ENSMUSP00000101124
resolver
ensp
ENSMUSP00000151372
resolver
ensp
ENSMUSP00000151389
resolver
ensp
ENSMUSP00000151671
resolver
ensp
ENSMUSP00000151921
resolver
ensp
ENSMUSP00000262922
resolver
ensp
ENSMUSP00000262924
resolver
ensp
ENSMUSP00000262928
resolver
ensp
ENSMUSP00000262931
resolver
ensp
ENSMUSP00000262932
resolver
enst
ENSMUST00000218598
resolver
enst
ENSMUST00000220263
resolver
genesymbol
Grik2
resolver
genesymbol_syn
Glur6
resolver
uniprot
A0A1W2P6S2
resolver
uniprot
A0A1W2P6S5
resolver
uniprot
Q60933
resolver
uniprot
Q6PAQ0
resolver
uniprot_entry
A0A1W2P6S2_MOUSE
resolver
uniprot_entry
A0A1W2P6S5_MOUSE
resolver
uniprot_entry
GRIK2_MOUSE
resolver
uniprot_entry
Q6PAQ0_MOUSE
resolver
uniprot_sec
Q60933
resolver
activity_regulation
ACTIVITY REGULATION: Ionotropic glutamate receptor activity is promoted by positive allosteric modulators that inhibit receptor desensitization (By similarity). Ionotropic glutamate receptor activity is inhibited by ion channel blockers (By similarity).Cold receptor activity is activated by temperatures between 10-19 degrees Celsius (PubMed:31474366). {ECO:0000250|UniProtKB:P42260, ECO:0000269|PubMed:31474366}.
uniprot
proteins
amino_acid_sequence
MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPSSGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA
uniprot
proteins
function
FUNCTION: Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid (PubMed:7681676, PubMed:19217376). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformational change leading to the opening of the cation channel, converting the chemical signal to an electrical impulse (By similarity). The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:17620617, PubMed:19217376, PubMed:20007474, PubMed:31474366, PubMed:7681676). Modulates cell surface expression of NETO2 (PubMed:19217376). In association with GRIK3, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (PubMed:17620617). {ECO:0000250|UniProtKB:P42260, ECO:0000269|PubMed:17620617, ECO:0000269|PubMed:19217376, ECO:0000269|PubMed:20007474, ECO:0000269|PubMed:31474366, ECO:0000269|PubMed:7681676}.; FUNCTION: Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366). Functions in dorsal root ganglion neurons (PubMed:31474366). {ECO:0000269|PubMed:31474366}.; FUNCTION: [Isoform GluR6-2]: Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. {ECO:0000269|PubMed:1379666}.
uniprot
proteins
mass_dalton
102486
uniprot
proteins
mutagenesis
MUTAGEN 151; /note="P->L: Abolishes cold receptor activity, no effect on ionotropic glutamate receptor activity."; /evidence="ECO:0000269|PubMed:31474366"; MUTAGEN 620; /note="M->R: Abolishes ionotropic glutamate receptor activity, no effect on cold receptor activity."; /evidence="ECO:0000269|PubMed:31474366"; MUTAGEN 622; /note="Q->R: Abolishes ionotropic glutamate receptor activity, no effect on cold receptor activity."; /evidence="ECO:0000269|PubMed:31474366
uniprot
proteins
post_translational_modification
PTM: Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1 (By similarity). {ECO:0000250|UniProtKB:P42260}.; PTM: Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome (By similarity). {ECO:0000250|UniProtKB:P42260}.; PTM: Phosphorylated by PKC at Ser-868 upon agonist activation, this directly enhance sumoylation. {ECO:0000250|UniProtKB:Q13002}.
uniprot
proteins
protein_family
GRIK2 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
12954862
uniprot
proteins
pubmed
1379666
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17620617
uniprot
proteins
pubmed
19217376
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20007474
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31474366
uniprot
proteins
pubmed
7681676
uniprot
proteins
pubmed
8260617
uniprot
proteins
pubmed
8700852
uniprot
proteins
sequence_length
908
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17620617}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P42260}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P42260}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P42260, ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 552..585; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:P42260"; TRANSMEM 630..660; /note="Helical; Name=M3"; /evidence="ECO:0000250|UniProtKB:P42260"; TRANSMEM 816..840; /note="Helical; Name=M4"; /evidence="ECO:0000250|UniProtKB:P42260
uniprot
proteins