Crh
entrez
81648
canonical
uniprot
P01143
canonical
ensembl
ENSRNOG00000012703
resolver
ensembl
ENSRNOG00055004773
resolver
ensembl
ENSRNOG00060021144
resolver
ensembl
ENSRNOG00065000302
resolver
ensembl
ENSRNOG00065019651
resolver
ensp
ENSRNOP00000016953
resolver
ensp
ENSRNOP00055005722
resolver
ensp
ENSRNOP00060030119
resolver
ensp
ENSRNOP00065000417
resolver
ensp
ENSRNOP00065026483
resolver
enst
ENSRNOT00000016953
resolver
enst
ENSRNOT00055007602
resolver
enst
ENSRNOT00060036596
resolver
enst
ENSRNOT00065000467
resolver
enst
ENSRNOT00065033118
resolver
genesymbol
Crh
resolver
uniprot_entry
CRH_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Specifically inhibited by CRHBP, which prevents binding to CRH receptors CRHR1 and CRHR2. {ECO:0000269|PubMed:1846945}.
uniprot
proteins
amino_acid_sequence
MRLRLLVSAGMLLVALSPCLPCRALLSRGSVSGAPRAPQPLNFLQPEQPQQPQPILIRMGEEYFLRLGNLNRSPAARLSPNSTPLTAGRGSRPSHDQAAANFFRVLLQQLQMPQRPLDSSTELAERGAEDALGGHQGALERERRSEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK
uniprot
proteins
function
FUNCTION: Hormone that plays a central role in whole body adaptation to stress (PubMed:1925600, PubMed:6603620, PubMed:8487193). Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptor CRHR1, and to a lower extent, CRHR2 (By similarity). CRH-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (By similarity). Acts as a 'placental clock' during pregnancy, regulating gestational length, fetal development and the timing of labor (By similarity). Also acts as a regulator of blastocyst implantation by promoting decidualization, regulating trophoblast invasion and facilitating maternal immune tolerance (PubMed:11590404). {ECO:0000250|UniProtKB:P06850, ECO:0000269|PubMed:11590404, ECO:0000269|PubMed:1925600, ECO:0000269|PubMed:6603620, ECO:0000269|PubMed:8487193}.
uniprot
proteins
mass_dalton
20680
uniprot
proteins
post_translational_modification
PTM: The precursor protein is cleaved into corticotropin-releasing hormone (CRH) by neuroendocrine convertases PCSK2. It is then amidated at the C-terminus, completing its activation. {ECO:0000250|UniProtKB:P06850}.
uniprot
proteins
pubmed
11590404
uniprot
proteins
pubmed
1846945
uniprot
proteins
pubmed
1925600
uniprot
proteins
pubmed
3274895
uniprot
proteins
pubmed
3876950
uniprot
proteins
pubmed
6603620
uniprot
proteins
pubmed
8487193
uniprot
proteins
sequence_length
187
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:6603620}.
uniprot
proteins