P0C089
uniprot
P0C089
canonical
amino_acid_sequence
MAASAWLEAGLARVLFYPTLLYTVFRGRVGGPAHRDWYHRIDHTVLLGALPLRSMTRRLVLDENVRGVITMNEEYETRFLCNTSKEWKNVGVEQLRLSTVDMTGVPTLANLHRGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHNWSPEEAIEAIAKIRSHISIRPSQLEILKEFHKEIAARAAKN
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.27
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (PubMed:16039589). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (PubMed:16039589). Probably involved in regulation of insulin secretion in pancreatic beta cells (PubMed:16039589). Prevents intrinsic apoptosis, by regulating mitochondrial membrane integrity (By similarity). {ECO:0000250|UniProtKB:Q66GT5, ECO:0000250|UniProtKB:Q8WUK0, ECO:0000269|PubMed:16039589}.
uniprot
proteins
mass_dalton
21886
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2. {ECO:0000250|UniProtKB:Q66GT5}.
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16039589
uniprot
proteins
sequence_length
193
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:16039589}; Peripheral membrane protein {ECO:0000269|PubMed:16039589}; Matrix side {ECO:0000269|PubMed:16039589}.
uniprot
proteins