Hdac3
entrez
84578
canonical
uniprot
Q6P6W3
canonical
ensembl
ENSRNOG00000019618
resolver
ensembl
ENSRNOG00055024500
resolver
ensembl
ENSRNOG00060021231
resolver
ensembl
ENSRNOG00065013286
resolver
ensp
ENSRNOP00000071791
resolver
ensp
ENSRNOP00000074429
resolver
ensp
ENSRNOP00055034409
resolver
ensp
ENSRNOP00055034424
resolver
ensp
ENSRNOP00060030437
resolver
ensp
ENSRNOP00060030502
resolver
ensp
ENSRNOP00065016908
resolver
ensp
ENSRNOP00065016913
resolver
enst
ENSRNOT00000078667
resolver
enst
ENSRNOT00000084735
resolver
enst
ENSRNOT00055042176
resolver
enst
ENSRNOT00055042191
resolver
enst
ENSRNOT00060036929
resolver
enst
ENSRNOT00060036994
resolver
enst
ENSRNOT00065021830
resolver
enst
ENSRNOT00065021835
resolver
genesymbol
Hdac3
resolver
uniprot
Q99PA0
resolver
uniprot_entry
HDAC3_RAT
resolver
uniprot_sec
Q99PA0
resolver
activity_regulation
ACTIVITY REGULATION: Inositol tetraphosphate (1D-myo-inositol 1,4,5,6-tetrakisphosphate) promotes the histone deacetylase activity by acting as an intermolecular glue between HDAC3 and NCOR2, thereby promoting its association with the N-Cor complex, a prerequisite for the histone deacetylase activity. {ECO:0000250|UniProtKB:O15379}.
uniprot
proteins
amino_acid_sequence
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVISQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
uniprot
proteins
ec_number
3.5.1.-
uniprot
proteins
ec_number
3.5.1.98
uniprot
proteins
function
FUNCTION: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes, such as N-Cor repressor complex, which activate the histone deacetylase activity. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression (By similarity). Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (By similarity). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (By similarity). Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner. During the activation phase, promotes the accumulation of ubiquitinated BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and BMAL1. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). Also functions as a deacetylase for non-histone targets, such as KAT5, MEF2D, MAPK14, RARA and STAT3. Serves as a corepressor of RARA, mediating its deacetylation and repression, leading to inhibition of RARE DNA element binding. In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response. In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl), 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) and isonicotinyl acyl groups from lysine residues, leading to protein decrotonylation, delactylation, de-2-hydroxyisobutyrylation and deisonicotinylation, respectively (By similarity). Catalyzes decrotonylation of MAPRE1/EB1 (By similarity). Mediates delactylation NBN/NBS1, thereby inhibiting DNA double-strand breaks (DSBs) via homologous recombination (HR) (By similarity). {ECO:0000250|UniProtKB:O15379, ECO:0000250|UniProtKB:O88895}.
uniprot
proteins
mass_dalton
48821
uniprot
proteins
post_translational_modification
PTM: Deubiquitinated on 'Lys-63'-linked ubiquitin chains by USP38; leading to a decreased level of histone acetylation. {ECO:0000250|UniProtKB:O15379}.; PTM: Sumoylated in vitro. {ECO:0000250|UniProtKB:O15379}.
uniprot
proteins
protein_family
HD type 1 subfamily
uniprot
proteins
protein_family
Histone deacetylase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16033423
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
428
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O15379}. Chromosome {ECO:0000250|UniProtKB:O15379}. Cytoplasm {ECO:0000250|UniProtKB:O15379}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O15379}. Note=Colocalizes with XBP1 and AKT1 in the cytoplasm. Predominantly expressed in the nucleus in the presence of CCAR2. {ECO:0000250|UniProtKB:O15379}.
uniprot
proteins