Cfap65
entrez
241116
canonical
uniprot
Q3V0B4
canonical
ensembl
ENSMUSG00000047021
resolver
ensp
ENSMUSP00000092440
resolver
enst
ENSMUST00000094844
resolver
genesymbol
Cfap65
resolver
genesymbol_syn
Ccdc108
resolver
uniprot_entry
CFA65_MOUSE
resolver
amino_acid_sequence
MLIQKNQCHITRTRENCDCTMNTVNEDLCLSASTLGSSSVTTQLVDPLDRKICLIRRQNDVKKRVIWGIEVAEKLHWKGWELGKETTRTLVLKNLSLKTQKMKYRPPKTKFFFTIIPQPIFLSPGITLTLPIVFRPLEAKEYTDQLWFEKEEGVFCVTLKATLPCYKLDCPSSLQLPMCALGDTVETWFCLNNVGDLPTFFTWEVPAPFQILPTTGLLEPGLGCKIKVTFEPLIAVIHEVEALCWYGKGNKQKNSINIQAAAKCAQLLVSIKHKGLEDQDQEGFQKVVHFGYVSVGSVAERQIRLYNPSAVNAPFKIEMAEHVLTKDPSFSCSTSQGIVPPGEKKCLSLFFHPKTLDSRAIDYFSIIPSGCATKTLLQVVGFCRGPDAVLQHSCVNFHWVKLGERREQTLWIENQSDCQAHFQFDIDCQESVFSIRPAFGTLAGKTRMTLHCAYQPTHPIISFRRVACLIHHQDPLFLDLIGTCHSDSIKPAILTPQHLTWYRTHLARGLTLYPPDILAAMLKEKKLERDEDGALILPIESLPMQELEDLPDQKYPNIPPMTEYFFDGTRDLAIFPPAVCLEPIDVDFGACPGPEAPNPVPLCLRNYTKGKITVVWTGRSDCPFWVTPVTSDVPPLKSIALRLYFQPSSPNCLYAVELEAFAVYKVLQCYSNIEEDCTVVPSWCLKVRARGHSYSPALEHHIPHYSLDSPQTFPAVSPGKPSYRSLFLVNKGSMLMTFSLAPNSSSDITLRPSSGLIGPGAHQVFLISTYPKGTSWRQHIFYLNFNFYPQYLKEVSMQSREEPLDLKLDTHKSIYFKPTWVGCSSTSNFTFHNPSRLPLQFEWRVSQEHQKVLAVQPSKGTIHPNENLTLTWIFSPLEEIKYLFRVGIWVWEARQSQKTKPQATVHYRIRLVGMGVTGCLSAKPVELDFGNVLVNSQEVKPLVLLNDGNCTLYYRLVLEQHRPKGLHSDPCALEFDHSEGTMPPHSQDTIYLTARPKVRSQYSWTISYCLLSQRAPPTNSMDGKKKALCHVSLAAAYPLLSVLDICSMGSTEGITRKHLWHLFSLDTLNSYLARDPTAKELTYKVPTRHSMSRTPPIFTPLKLDFNFGAAPHNALPSVVLLVLKNCGLVPLDWAFLFPSDQQLDLDLWVEQEDLNSNELHQMRAEDNSLFSINPKTGSLNPGQEQMVEFTYRHLFVGTDRLSVLFKVSHGREILLQFIGVTVKLEQKYVHFTSTIHQFIPVPIGDTLPPRQIYELYNGGSVPVTYEVQVSVLSKVQEKNFDHPIFCCLNPKGDIQPGTTARILWIFSPIEAKTYTVEVPIHIIGWNSAVVCFQGVGYDPCVMGDTAPFHSISSWDSSSISSRLMVPGQNVFLSQSHISLGNIPVQSKCSRLFFLNNISKNETIVFTWKPRSLDFGEVTVSPMEGEVGPEEGAPILVTLKASVHASFYSIDLICKVYQRELMRQYHKELQEWNEEKARQEVEFTITDRKVKRRAYCAAHEPPKKYKTLPPITNQPPLNRPATWNLKLAKKETSWPCPQPPVPGLLCLGLTARAHATDYYLANFFSEFPCHFLYRELPKKKSSKEESKSSEELPDKKGPVSRQKQQLLVDCLTSIIRGLLEDKNFHNAVDQNLVEQVPYFCQFWNEQSARFLAQKSSLYLVPILSLPPSYEGRKSKEQEEDLFGKMPGGQEDDEEEEEDEEEAEEEEEEIEEEMSKDEEDIDKDAKMTWSGIKVTETSQHSLQWQWQQDLKTIIKEETESDEKEAIGRLPAFANLQEAILENMIQNILVEASRGEVVLTSRPRIIALPPVSMHRTDNLLQMSQGDVLCSGMQHPDCLLVSASSPSNMTT
uniprot
proteins
function
FUNCTION: Plays a role in flagellar formation and sperm motility (PubMed:31501240). Essential for acrosome formation, manchette organization, spermatid head morphogenesis and mitochondrial sheath assembly within the sperm flagellum during spermiogenesis (PubMed:34231842). Also required for proper assembly and stabilization of the C2a projection, a structural subunit of the central pair apparatus within the axoneme of motile cilia and flagella (PubMed:39853433). {ECO:0000269|PubMed:31501240, ECO:0000269|PubMed:34231842, ECO:0000269|PubMed:39853433}.
uniprot
proteins
mass_dalton
209134
uniprot
proteins
protein_family
CFAP65 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31413122
uniprot
proteins
pubmed
31501240
uniprot
proteins
pubmed
31571197
uniprot
proteins
pubmed
33472045
uniprot
proteins
pubmed
34231842
uniprot
proteins
pubmed
39092789
uniprot
proteins
pubmed
39853433
uniprot
proteins
sequence_length
1847
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:31571197}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q6ZU64}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:31571197, ECO:0000269|PubMed:34231842}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:34231842}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:39853433}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:39853433}. Note=Expressed in the cytoplasm of the spermatogonia, round spermatids, early elongating spermatids and late elongating spermatids and in the flagella of epididymal spermatozoa. Localizes to the central apparatus of the flagellar axoneme. {ECO:0000269|PubMed:31571197, ECO:0000269|PubMed:39092789}.
uniprot
proteins
transmembrane_region
TRANSMEM 112..132; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins