Calhm2
entrez
72691
canonical
uniprot
Q8VEC4
canonical
ensembl
ENSMUSG00000033033
resolver
ensp
ENSMUSP00000047278
resolver
enst
ENSMUST00000035822
resolver
genesymbol
Calhm2
resolver
genesymbol_syn
Fam26b
resolver
uniprot
Q3TDQ7
resolver
uniprot
Q3V3G1
resolver
uniprot
Q4VA34
resolver
uniprot
Q8BT85
resolver
uniprot
Q8C246
resolver
uniprot_entry
CAHM2_MOUSE
resolver
uniprot_entry
Q3V3G1_MOUSE
resolver
uniprot_entry
Q4VA34_MOUSE
resolver
uniprot_sec
Q3TDQ7
resolver
uniprot_sec
Q8BT85
resolver
uniprot_sec
Q8C246
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by divalent cations such as Co(2+) and Ni(2+). {ECO:0000269|PubMed:29180673}.
uniprot
proteins
amino_acid_sequence
MAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLTAIGVPALALFLIGVILNNHTWNLVAECQYRRAKNCSAAPNFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAGDKGFPPAHATEVLARFPCGEGPANLSSFREEVSRRLKYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRTNEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELVAKFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLTGNGTAPDNVEMALLTA
uniprot
proteins
function
FUNCTION: Pore-forming subunit of Ca(2+) homeostasis modulator channels. Mediates ATP release from astrocytes and ATP-induced Ca(2+) influx in microglia thus regulating neuronal ATP and Ca(2+) homeostasis, synaptic transmission and neuroinflammatory response. May form intercellular gap junctions. The gating mechanism remains unknown. {ECO:0000250|UniProtKB:Q9HA72, ECO:0000269|PubMed:29180673, ECO:0000269|PubMed:34433553}.
uniprot
proteins
mass_dalton
35823
uniprot
proteins
mutagenesis
MUTAGEN 87; /note="Q->A: Decreases ATP release."; /evidence="ECO:0000269|PubMed:29180673"; MUTAGEN 103; /note="L->A: Does not affect ATP release."; /evidence="ECO:0000269|PubMed:29180673"; MUTAGEN 105; /note="S->A: Does not affect ATP release."; /evidence="ECO:0000269|PubMed:29180673"; MUTAGEN 132; /note="L->A: Decreases ATP release."; /evidence="ECO:0000269|PubMed:29180673
uniprot
proteins
protein_family
CALHM family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
29180673
uniprot
proteins
pubmed
34433553
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29180673}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..43; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:Q9HA72"; TRANSMEM 53..76; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:Q9HA72"; TRANSMEM 102..132; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:Q9HA72"; TRANSMEM 180..206; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:Q9HA72
uniprot
proteins