MIGA2
entrez
84895
canonical
uniprot
Q7L4E1
canonical
ensembl
ENSG00000148343
resolver
ensp
ENSP00000506871
resolver
ensp
ENSP00000671615
resolver
genesymbol
MIGA2
resolver
genesymbol_syn
C9orf54
resolver
genesymbol_syn
FAM73B
resolver
hgnc
HGNC:23621
resolver
uniprot
B4DZP8
resolver
uniprot
Q8NBM3
resolver
uniprot
Q8TEJ6
resolver
uniprot
Q969E6
resolver
uniprot_entry
B4DZP8_HUMAN
resolver
uniprot_entry
MIGA2_HUMAN
resolver
uniprot_sec
Q8NBM3
resolver
uniprot_sec
Q8TEJ6
resolver
uniprot_sec
Q969E6
resolver
amino_acid_sequence
MAFRRAEGTSMIQALAMTVAEIPVFLYTTFGQSAFSQLRLTPGLRKVLFATALGTVALALAAHQLKRRRRRKKQVGPEMGGEQLGTVPLPILLARKVPSVKKGYSSRRVQSPSSKSNDTLSGISSIEPSKHSGSSHSVASMMAVNSSSPTAACSGLWDARGMEESLTTSDGNAESLYMQGMELFEEALQKWEQALSVGQRGDSGSTPMPRDGLRNPETASEPLSEPESQRKEFAEKLESLLHRAYHLQEEFGSTFPADSMLLDLERTLMLPLTEGSLRLRADDEDSLTSEDSFFSATELFESLQTGDYPIPLSRPAAAYEEALQLVKEGRVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLLEDKSNQLFFGKVGRQMVTGLMTKAEKSPKGFLESYEEMLSYALRPETWATTRLELEGRGVVCMSFFDIVLDFILMDAFEDLENPPASVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKPQLAEVCAFFKHQIVQYLRDMFDLDNVRYTSLPALADDILQLSRRRSEILLGYLGVPAASSAGVNGALPRENGPLGELQ
uniprot
proteins
function
FUNCTION: Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}.
uniprot
proteins
mass_dalton
65531
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-295 of the FFAT motif activates interaction with MOSPD2, VAPA and VAPB. {ECO:0000269|PubMed:33124732}.
uniprot
proteins
protein_family
Mitoguardin family
uniprot
proteins
pubmed
12693554
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26711011
uniprot
proteins
pubmed
33124732
uniprot
proteins
pubmed
38843396
uniprot
proteins
sequence_length
593
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:26711011}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 42..62; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins