RAD54L2
entrez
23132
canonical
uniprot
Q9Y4B4
canonical
ensembl
ENSG00000164080
resolver
ensp
ENSP00000386520
resolver
ensp
ENSP00000410283
resolver
ensp
ENSP00000507587
resolver
ensp
ENSP00000541550
resolver
ensp
ENSP00000541551
resolver
ensp
ENSP00000541552
resolver
ensp
ENSP00000541553
resolver
ensp
ENSP00000541554
resolver
ensp
ENSP00000600272
resolver
ensp
ENSP00000600273
resolver
ensp
ENSP00000631193
resolver
enst
ENST00000409535
resolver
enst
ENST00000684192
resolver
enst
ENST00000871491
resolver
enst
ENST00000871492
resolver
enst
ENST00000871493
resolver
enst
ENST00000871494
resolver
enst
ENST00000930213
resolver
enst
ENST00000930214
resolver
genesymbol
RAD54L2
resolver
genesymbol_syn
ARIP4
resolver
genesymbol_syn
KIAA0809
resolver
hgnc
HGNC:29123
resolver
uniprot
B3KV54
resolver
uniprot
Q8TB57
resolver
uniprot
Q9BV54
resolver
uniprot_entry
ARIP4_HUMAN
resolver
uniprot_entry
B3KV54_HUMAN
resolver
uniprot_sec
Q8TB57
resolver
uniprot_sec
Q9BV54
resolver
activity_regulation
ACTIVITY REGULATION: Enzyme activity is enhanced by dsDNA (double-stranded DNA) and ssDNA (single-stranded DNA). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MSDESASGSDPDLDPDVELEDAEEEEEEEEVAVEECDRDDEEDLLDDPSLEGMCGTEHAQLGEDGQQPPRCTSTTSSQSEPSEQLRRHQGKNLASEDPKKKRAQKPSHMRRNIRKLLREDQLEPVTKAAQQEELERRKRLEQQRKDYAAPIPTVPLEFLPEEIALRASDGPQLPPRVLAQEVICLDSSSGSEDEKSSRDEVIELSSGEEDTLHIVDSSESVSEDDEEEEKGGTHVNDVLNQRDALGRVLVNLNHPPEEENVFLAPQLARAVKPHQIGGIRFLYDNLVESLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWLPPPEALPADNKPEEVQPRFFKVHILNDEHKTMASRAKVMADWVSEGGVLLMGYEMYRLLTLKKSFATGRPKKTKKRSHPVIIDLDEEDRQQEFRREFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILVRLSKIQRDLYTQFMDRFRDCGSSGWLGLNPLKAFCVCCKIWNHPDVLYEALQKESLANEQDLDVEELGSAGTSARCPPQGTKGKGEDSTLASSMGEATNSKFLQGVGFNPFQERGNNIVTYEWAKDLLTNYQTGVLENSPKMVLLFHLIEESVKLGDKILVFSQSLSTLALIEEFLGKREVPCPPGTEGQGAQKWVRNISYFRLDGSTPAFERERLINQFNDPSNLTTWLFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQKKPCYIYRLVADYTLEKKIYDRQISKQGMSDRVVDDLNPMLNFTRKEVENLLHFVEKEPAPQVSLNVKGIKESVLQLACLKYPHLITKEPFEHESLLLNRKDHKLTKAEKKAAKKSYEEDKRTSVPYTRPSYAQYYPASDQSLTSIPAFSQRNWQPTLKGDEKPVASVRPVQSTPIPMMPRHVPLGGSVSSASSTNPSMNFPINYLQRAGVLVQKVVTTTDIVIPGLNSSTDVQARINAGESIHIIRGTKGTYIRTSDGRIFAVRATGKPKVPEDGRMAASGSQGPSCESTSNGRHSASSPKAPDPEGLARPVSPDSPEIISELQQYADVAAARESRQSSPSTNAALPGPPAQLMDSSAVPGTALGTEPRLGGHCLNSSLLVTGQPCGDRHPVLDLRGHKRKLATPPAAQESSRRRSRKGHLPAPVQPYEHGYPVSGGFAMPPVSLNHNLTTPFTSQAGENSLFMGSTPSYYQLSNLLADARLVFPVTTDPLVPAGPVSSSSTATSVTASNPSFMLNPSVPGILPSYSLPFSQPLLSEPRMFAPFPSPVLPSNLSRGMSIYPGYMSPHAGYPAGGLLRSQVPPFDSHEVAEVGFSSNDDEDKDDDVIEVTGK
uniprot
proteins
ec_number
5.6.2.-
uniprot
proteins
function
FUNCTION: Helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner (By similarity). May stimulate the release of RNA polymerase II, that has paused near the transcription start sites of AR-targeted genes and unwind R-loops formed at these sites; R-loops result from the hybridization of the short RNA strand nascently synthesized by the paused RNA polymerase II molecule and the DNA template (PubMed:39028815). May also stimulate double-strand break formation by TOP2B, which appears important for transcriptional output (PubMed:39028815). Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250|UniProtKB:Q99NG0, ECO:0000269|PubMed:39028815}.
uniprot
proteins
mass_dalton
162769
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000250|UniProtKB:Q99NG0}.
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
39028815
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
1467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:39028815}. Chromosome {ECO:0000269|PubMed:39028815}. Note=Localizes in speckle-like nuclear compartments (By similarity). Localizes to promoter proximal regions on chromatin (PubMed:39028815). {ECO:0000250|UniProtKB:Q99NG0, ECO:0000269|PubMed:39028815}.
uniprot
proteins