CENPW
entrez
387103
canonical
uniprot
Q5EE01
canonical
ensembl
ENSG00000203760
resolver
ensp
ENSP00000357308
resolver
ensp
ENSP00000357309
resolver
ensp
ENSP00000357311
resolver
enst
ENST00000368326
resolver
genesymbol
CENPW
resolver
genesymbol_syn
C6orf173
resolver
genesymbol_syn
CUG2
resolver
hgnc
HGNC:21488
resolver
uniprot
A0A0A0MRK5
resolver
uniprot
A6NIR0
resolver
uniprot
A6NJC2
resolver
uniprot_entry
A0A0A0MRK5_HUMAN
resolver
uniprot_entry
CENPW_HUMAN
resolver
uniprot_sec
A6NIR0
resolver
uniprot_sec
A6NJC2
resolver
amino_acid_sequence
MALSTIVSQRKQIKRKAPRGFLKRVFKRKKPQLRLEKSGDLLVHLNCLLFVHRLAEESRTNACASKCRVINKEHVLAAAKVILKKSRG
uniprot
proteins
function
FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000250, ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:19533040, ECO:0000269|PubMed:21695110, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22304917}.
uniprot
proteins
mass_dalton
10061
uniprot
proteins
protein_family
CENP-W/WIP1 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17079448
uniprot
proteins
pubmed
17610844
uniprot
proteins
pubmed
19070575
uniprot
proteins
pubmed
19533040
uniprot
proteins
pubmed
21695110
uniprot
proteins
pubmed
22002061
uniprot
proteins
pubmed
22304917
uniprot
proteins
sequence_length
88
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17610844}. Chromosome, centromere {ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:19533040, ECO:0000269|PubMed:22304917}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:22304917}. Nucleus matrix {ECO:0000269|PubMed:22002061}. Nucleus, nucleolus {ECO:0000269|PubMed:22002061}. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis. {ECO:0000250|UniProtKB:P0DJH6}.
uniprot
proteins