Ppp1cc
entrez
24669
canonical
uniprot
P63088
canonical
ensembl
ENSRNOG00000001269
resolver
ensembl
ENSRNOG00055015662
resolver
ensembl
ENSRNOG00060001709
resolver
ensembl
ENSRNOG00065007334
resolver
ensp
ENSRNOP00000047912
resolver
ensp
ENSRNOP00000071829
resolver
genesymbol
Ppp1cc
resolver
uniprot
O09186
resolver
uniprot
O09189
resolver
uniprot
P37139
resolver
uniprot
Q64679
resolver
uniprot
Q6AYZ4
resolver
uniprot_entry
PP1G_RAT
resolver
uniprot_entry
Q6AYZ4_RAT
resolver
uniprot_sec
O09186
resolver
uniprot_sec
O09189
resolver
uniprot_sec
P37139
resolver
uniprot_sec
Q64679
resolver
activity_regulation
ACTIVITY REGULATION: Inactivated by binding to URI1. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MADIDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKKKPNATRPVTPPRGMITKQAKK
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Regulates the recruitment of the SKA complex to kinetochores (By similarity). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (By similarity). Dephosphorylates MKI67 at the onset of anaphase (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity). {ECO:0000250|UniProtKB:P36873, ECO:0000250|UniProtKB:P63087}.; FUNCTION: [Isoform 2]: Required for normal male fertility. {ECO:0000250|UniProtKB:P36873}.
uniprot
proteins
mass_dalton
36984
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NEK2. {ECO:0000250}.
uniprot
proteins
protein_family
PP-1 subfamily
uniprot
proteins
protein_family
PPP phosphatase family
uniprot
proteins
pubmed
10504266
uniprot
proteins
pubmed
10585469
uniprot
proteins
pubmed
1653777
uniprot
proteins
pubmed
17636256
uniprot
proteins
pubmed
2177460
uniprot
proteins
pubmed
7720853
uniprot
proteins
pubmed
8393674
uniprot
proteins
pubmed
9841883
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P36873}. Nucleus {ECO:0000250|UniProtKB:P36873}. Cleavage furrow {ECO:0000250|UniProtKB:P36873}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P36873}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P36873}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P36873}. Nucleus speckle {ECO:0000250|UniProtKB:P36873}. Midbody {ECO:0000250|UniProtKB:P36873}. Mitochondrion {ECO:0000250|UniProtKB:P36873}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:P36873}. Note=Colocalizes with SPZ1 in the nucleus. Colocalizes with URI1 at mitochondrion. Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase. {ECO:0000250|UniProtKB:P36873, ECO:0000250|UniProtKB:P63087}.
uniprot
proteins