Cd163
entrez
93671
canonical
uniprot
Q2VLH6
canonical
ensembl
ENSMUSG00000008845
resolver
ensp
ENSMUSP00000032234
resolver
ensp
ENSMUSP00000108160
resolver
ensp
ENSMUSP00000251834
resolver
genesymbol
Cd163
resolver
genesymbol_syn
M130
resolver
uniprot
A6H691
resolver
uniprot
B7ZMW6
resolver
uniprot
Q2VLH5
resolver
uniprot
Q99MX8
resolver
uniprot_entry
B7ZMW6_MOUSE
resolver
uniprot_entry
C163A_MOUSE
resolver
uniprot_sec
A6H691
resolver
uniprot_sec
Q2VLH5
resolver
uniprot_sec
Q99MX8
resolver
amino_acid_sequence
MGGHRMVLLGGAGSPGCKRFVHLGFFVVAVSSLLSASAVTNAPGEMKKELRLAGGENNCSGRVELKIHDKWGTVCSNGWSMNEVSVVCQQLGCPTSIKALGWANSSAGSGYIWMDKVSCTGNESALWDCKHDGWGKHNCTHEKDAGVTCSDGSNLEMRLVNSAGHRCLGRVEIKFQGKWGTVCDDNFSKDHASVICKQLGCGSAISFSGSAKLGAGSGPIWLDDLACNGNESALWDCKHRGWGKHNCDHAEDVGVICLEGADLSLRLVDGVSRCSGRLEVRFQGEWGTVCDDNWDLRDASVVCKQLGCPTAISAIGRVNASEGSGQIWLDNISCEGHEATLWECKHQEWGKHYCHHREDAGVTCSDGADLELRLVGGGSRCAGIVEVEIQKLTGKMCSRGWTLADADVVCRQLGCGSALQTQAKIYSKTGATNTWLFPGSCNGNETTFWQCKNWQWGGLSCDNFEEAKVTCSGHREPRLVGGEIPCSGRVEVKHGDVWGSVCDFDLSLEAASVVCRELQCGTVVSILGGAHFGEGSGQIWGEEFQCSGDESHLSLCSVAPPLDRTCTHSRDVSVVCSRYIDIRLAGGESSCEGRVELKTLGAWGPLCSSHWDMEDAHVLCQQLKCGVAQSIPEGAHFGKGAGQVWSHMFHCTGTEEHIGDCLMTALGAPTCSEGQVASVICSGNQSQTLLPCSSLSPVQTTSSTIPKESEVPCIASGQLRLVGGGGRCAGRVEVYHEGSWGTVCDDNWDMTDANVVCKQLDCGVAINATGSAYFGEGAGAIWLDEVICTGKESHIWQCHSHGWGRHNCRHKEDAGVICSEFMSLRLTNEAHKENCTGRLEVFYNGTWGSIGSSNMSPTTVGVVCRQLGCADNGTVKPIPSDKTPSRPMWVDRVQCPKGVDTLWQCPSSPWKQRQASPSSQESWIICDNKIRLQEGHTDCSGRVEIWHKGSWGTVCDDSWDLNDAKVVCKQLGCGQAVKALKEAAFGPGTGPIWLNEIKCRGNESSLWDCPAKPWSHSDCGHKEDASIQCLPKMTSESHHGTGHPTLTALLVCGAILLVLLIVFLLWTLKRRQIQRLTVSSRGEVLIHQVQYQEMDSKADDLDLLKSSGVIQRHTEKENDNL
uniprot
proteins
function
FUNCTION: Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). {ECO:0000250}.; FUNCTION: After shedding, the soluble form (sCD163) may play an anti-inflammatory role. {ECO:0000250}.
uniprot
proteins
mass_dalton
120921
uniprot
proteins
post_translational_modification
PTM: A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
11345593
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Soluble CD163]: Secreted {ECO:0000250|UniProtKB:Q86VB7}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86VB7}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q86VB7}.
uniprot
proteins
transmembrane_region
TRANSMEM 1046..1066; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins