GNA12
entrez
2768
canonical
uniprot
Q03113
canonical
ensembl
ENSG00000146535
resolver
ensp
ENSP00000275364
resolver
ensp
ENSP00000385935
resolver
ensp
ENSP00000386054
resolver
ensp
ENSP00000624453
resolver
enst
ENST00000407653
resolver
genesymbol
GNA12
resolver
hgnc
HGNC:4380
resolver
uniprot
A4D204
resolver
uniprot
B3KXS2
resolver
uniprot
B7Z3F7
resolver
uniprot
E9PC54
resolver
uniprot
Q2T9L1
resolver
uniprot
Q5PPR5
resolver
uniprot
Q6ZQV4
resolver
uniprot
Q86UM8
resolver
uniprot
Q8TD71
resolver
uniprot
Q9UDU9
resolver
uniprot_entry
E9PC54_HUMAN
resolver
uniprot_entry
GNA12_HUMAN
resolver
uniprot_entry
Q6ZQV4_HUMAN
resolver
uniprot_sec
A4D204
resolver
uniprot_sec
B3KXS2
resolver
uniprot_sec
B7Z3F7
resolver
uniprot_sec
Q2T9L1
resolver
uniprot_sec
Q5PPR5
resolver
uniprot_sec
Q86UM8
resolver
uniprot_sec
Q8TD71
resolver
uniprot_sec
Q9UDU9
resolver
amino_acid_sequence
MSGVVRTLSRCLLPAEAGGARERRAGSGARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDTENVRFVFHAVKDTILQENLKDIMLQ
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:12515866, PubMed:15240885, PubMed:15525651, PubMed:16705036, PubMed:16787920, PubMed:17565996, PubMed:22609986, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:12515866, PubMed:15240885, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production (PubMed:16705036, PubMed:16787920, PubMed:23762476, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986). {ECO:0000250|UniProtKB:P27600, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:12515866, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:15525651, ECO:0000269|PubMed:15980433, ECO:0000269|PubMed:16705036, ECO:0000269|PubMed:16787920, ECO:0000269|PubMed:17565996, ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:23762476, ECO:0000269|PubMed:27084452}.
uniprot
proteins
mass_dalton
44279
uniprot
proteins
protein_family
G(12) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
pubmed
10026210
uniprot
proteins
pubmed
11094164
uniprot
proteins
pubmed
11976333
uniprot
proteins
pubmed
12515866
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15240885
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15525651
uniprot
proteins
pubmed
15980433
uniprot
proteins
pubmed
16202387
uniprot
proteins
pubmed
16705036
uniprot
proteins
pubmed
16787920
uniprot
proteins
pubmed
17565996
uniprot
proteins
pubmed
18703424
uniprot
proteins
pubmed
22609986
uniprot
proteins
pubmed
23762476
uniprot
proteins
pubmed
27084452
uniprot
proteins
pubmed
8423800
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:15980433}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q63210}; Cytoplasmic side {ECO:0000250|UniProtKB:Q63210}. Lateral cell membrane {ECO:0000269|PubMed:15525651}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q63210}; Cytoplasmic side {ECO:0000250|UniProtKB:Q63210}. Cytoplasm {ECO:0000269|PubMed:15525651}. Note=Associated to the plasma membrane via lipid-anchor (By similarity). CDH1 enhances cell membrane localization (PubMed:15525651). {ECO:0000250|UniProtKB:P27600, ECO:0000269|PubMed:15525651}.
uniprot
proteins