Kcna4
entrez
25469
canonical
uniprot
P15385
canonical
ensembl
ENSRNOG00000004918
resolver
ensp
ENSRNOP00000006524
resolver
ensp
ENSRNOP00000107472
resolver
ensp
ENSRNOP00000110060
resolver
ensp
ENSRNOP00000112159
resolver
ensp
ENSRNOP00000112783
resolver
enst
ENSRNOT00000006524
resolver
enst
ENSRNOT00000132453
resolver
enst
ENSRNOT00000147371
resolver
enst
ENSRNOT00000153929
resolver
enst
ENSRNOT00000167706
resolver
genesymbol
Kcna4
resolver
uniprot
G3V6L7
resolver
uniprot_entry
G3V6L7_RAT
resolver
uniprot_entry
KCNA4_RAT
resolver
amino_acid_sequence
MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGTGGSGGGPHHHHQTRGAYSSHDPQGSRGSREEEATRTEKKKKLHHRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEEDHGDGCSYTDLLPQDDGGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLIMALSAGGHSRLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCGKEEKCQGKGDDSETDKNNCSNAKAVETDV
uniprot
proteins
function
FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:10896669, PubMed:2348860, PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:2384173). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:2348860). {ECO:0000269|PubMed:10896669, ECO:0000269|PubMed:2348860, ECO:0000269|PubMed:2384173, ECO:0000269|PubMed:2555158, ECO:0000269|PubMed:8495559}.
uniprot
proteins
mass_dalton
73390
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10896669}.
uniprot
proteins
protein_family
A (Shaker) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv1.4/KCNA4 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10896669
uniprot
proteins
pubmed
11988171
uniprot
proteins
pubmed
12590144
uniprot
proteins
pubmed
12632190
uniprot
proteins
pubmed
1497894
uniprot
proteins
pubmed
16504945
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2348860
uniprot
proteins
pubmed
2384173
uniprot
proteins
pubmed
2555158
uniprot
proteins
pubmed
7477295
uniprot
proteins
pubmed
8361540
uniprot
proteins
pubmed
8495559
uniprot
proteins
pubmed
9000078
uniprot
proteins
pubmed
9334400
uniprot
proteins
sequence_length
655
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10896669, ECO:0000269|PubMed:2348860, ECO:0000269|PubMed:2384173}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000269|PubMed:10896669, ECO:0000269|PubMed:1497894, ECO:0000305|PubMed:8361540}.
uniprot
proteins
transmembrane_region
TRANSMEM 307..328; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 373..394; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 406..426; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 442..462; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 478..499; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 541..569; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:P63142
uniprot
proteins