OLIG2
entrez
10215
canonical
uniprot
Q13516
canonical
ensembl
ENSG00000205927
resolver
ensp
ENSP00000331040
resolver
ensp
ENSP00000371794
resolver
ensp
ENSP00000547279
resolver
ensp
ENSP00000547280
resolver
ensp
ENSP00000630667
resolver
enst
ENST00000333337
resolver
enst
ENST00000382357
resolver
enst
ENST00000877220
resolver
enst
ENST00000877221
resolver
enst
ENST00000960608
resolver
genesymbol
OLIG2
resolver
genesymbol_syn
BHLHB1
resolver
genesymbol_syn
BHLHE19
resolver
genesymbol_syn
PRKCBP2
resolver
genesymbol_syn
RACK17
resolver
hgnc
HGNC:9398
resolver
uniprot
B3KRF3
resolver
uniprot
Q05BP9
resolver
uniprot
Q49AL3
resolver
uniprot
Q86X04
resolver
uniprot
Q9NZ14
resolver
uniprot_entry
OLIG2_HUMAN
resolver
uniprot_sec
B3KRF3
resolver
uniprot_sec
Q05BP9
resolver
uniprot_sec
Q49AL3
resolver
uniprot_sec
Q86X04
resolver
uniprot_sec
Q9NZ14
resolver
amino_acid_sequence
MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMGSAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCPCSMCQVPPPHHHVSAMGAGSLPRLTSDAK
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA. {ECO:0000269|PubMed:10737801}.
uniprot
proteins
function
FUNCTION: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Works in coordination with ZNF488 to promote oligodendrocyte differentiation. Orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis. In cooperation with OLIG2, activates oligodendrocyte precursor cells (OPCs) formation while repressing the generation of olfactory bulb interneuron intermediate progenitors (OBIN) generation through transcriptional regulation of GSX2. Mechanistically, binds and silences multiple conserved enhancer elements of GSX2. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. {ECO:0000250|UniProtKB:Q9EQW6}.
uniprot
proteins
mass_dalton
32385
uniprot
proteins
post_translational_modification
PTM: 'Lys-63'-linked polyubiquitinated by RNF220; leading to stabilization during oligodendroglial development and myelination. {ECO:0000250|UniProtKB:Q8TAK6}.
uniprot
proteins
pubmed
10737801
uniprot
proteins
pubmed
11498220
uniprot
proteins
pubmed
11526205
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
38324685
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. Cytoplasm {ECO:0000250}. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. {ECO:0000250}.
uniprot
proteins