Cox8c
entrez
360229
canonical
uniprot
Q7TNN2
canonical
ensembl
ENSRNOG00000031106
resolver
ensembl
ENSRNOG00055016323
resolver
ensembl
ENSRNOG00060004960
resolver
ensembl
ENSRNOG00065014287
resolver
ensp
ENSRNOP00000047295
resolver
ensp
ENSRNOP00055022205
resolver
ensp
ENSRNOP00060006221
resolver
ensp
ENSRNOP00065018325
resolver
enst
ENSRNOT00000052296
resolver
enst
ENSRNOT00055027670
resolver
enst
ENSRNOT00060008275
resolver
enst
ENSRNOT00065023559
resolver
genesymbol
Cox8c
resolver
uniprot_entry
COX8C_RAT
resolver
amino_acid_sequence
MSRLLQFCSSLLRHRVVLFSKPGHSGRLSHSESPQNQVLTPTESVVGIVVFFATFFIPAAYVMSNLKFFKGE
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P10175}.
uniprot
proteins
mass_dalton
8073
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P10175}.
uniprot
proteins
protein_family
Cytochrome c oxidase VIII family
uniprot
proteins
pubmed
12909344
uniprot
proteins
sequence_length
72
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P10175}; Single-pass membrane protein {ECO:0000250|UniProtKB:P10175}.
uniprot
proteins
transmembrane_region
TRANSMEM 41..64; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P10175
uniprot
proteins