P19218
uniprot
P19218
canonical
amino_acid_sequence
MVACDLLWLAAASCLLTLVFPSTTHQGYGNPRNTSNVDLDCGAPGSSSAGICFDPCQNHTVLNDPSRSTENTVSSEECDSHLRGWYRFVGDGGVKMPETCVNVYRCHTYAPMWLSGSHPILGDGIVNRTACANWNENCCFWSSEVQVKACLGESGEYHVYKLQGTPECSLRYCTDPSTAPKKCEIACRPEEECVFQNNSWTCVCRQDLNVSDTLSLQPLLDCGANEIKVKLDKCLLGGLGFKEDIITYLNDRNCRGTMKDEPNNWVSTTSPVVANDCGNILENNGTQAIYRNTLSLATDFIIRDFLVNVNFQCAYPLDMNVSLQTALQPIVSSLNVDVGGAGEFTVTMALFQDQSYTHPYEGSKVLLPVENILYVGALLNRGDTSRFKLLLTNCYATPSGDRNDIVKYFIIRNRCPNQRDSTINVEENGVSSESRFSVQMFMFAGNYDLVFLHCEVYLCDSTTEQCQPSCSTSRLRSSEPAIDLTRVLDIGPITKKSVQNPDTSNGTPRNTGFLLAWPTFFLPVFLAWLF
uniprot
proteins
function
FUNCTION: Functions as an intestinal M-cell transcytotic receptor specific of type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response. {ECO:0000250|UniProtKB:Q9D733}.
uniprot
proteins
mass_dalton
58708
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:1999417, ECO:0000269|PubMed:6479170}.
uniprot
proteins
pubmed
11853552
uniprot
proteins
pubmed
1999417
uniprot
proteins
pubmed
2216794
uniprot
proteins
pubmed
6479170
uniprot
proteins
pubmed
8352773
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Zymogen granule membrane {ECO:0000269|PubMed:1999417, ECO:0000269|PubMed:6479170}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11853552, ECO:0000269|PubMed:1999417}. Secreted {ECO:0000305|PubMed:6479170}. Cell membrane {ECO:0000269|PubMed:1999417, ECO:0000269|PubMed:6479170}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11853552, ECO:0000269|PubMed:1999417}. Apical cell membrane {ECO:0000250|UniProtKB:Q9D733}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11853552, ECO:0000269|PubMed:1999417}. Membrane raft {ECO:0000269|PubMed:11853552}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11853552, ECO:0000269|PubMed:1999417}. Endosome {ECO:0000250|UniProtKB:Q9D733}. Note=Secreted, after cleavage, in the pancreatic juice. {ECO:0000305|PubMed:6479170}.
uniprot
proteins