Sh2d1a
entrez
20400
canonical
uniprot
O88890
canonical
ensembl
ENSMUSG00000005696
resolver
ensp
ENSMUSP00000005839
resolver
ensp
ENSMUSP00000110722
resolver
genesymbol
Sh2d1a
resolver
genesymbol_syn
Xlp
resolver
uniprot
A2ANL8
resolver
uniprot
B2RWI0
resolver
uniprot
Q544F1
resolver
uniprot
Q9QWV6
resolver
uniprot
W0BZ77
resolver
uniprot_entry
B2RWI0_MOUSE
resolver
uniprot_entry
Q544F1_MOUSE
resolver
uniprot_entry
SH21A_MOUSE
resolver
uniprot_entry
W0BZ77_MOUSE
resolver
uniprot_sec
A2ANL8
resolver
uniprot_sec
Q9QWV6
resolver
amino_acid_sequence
MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDICLNAP
uniprot
proteins
function
FUNCTION: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (By similarity). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions (PubMed:22683124). Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation (PubMed:19648922). In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (PubMed:22683124). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. {ECO:0000250|UniProtKB:B2RZ59, ECO:0000250|UniProtKB:O60880, ECO:0000269|PubMed:16223723, ECO:0000269|PubMed:19648922, ECO:0000269|PubMed:20962259, ECO:0000269|PubMed:22683124, ECO:0000305|PubMed:21219180}.
uniprot
proteins
mass_dalton
13904
uniprot
proteins
mutagenesis
MUTAGEN 32; /note="R->K: No effect on interaction with FYNSH3 domain."; /evidence="ECO:0000269|PubMed:12545173"; MUTAGEN 68; /note="T->I: No effect on interaction with FYNSH3 domain."; /evidence="ECO:0000269|PubMed:12545173"; MUTAGEN 70; /note="P->A: No effect on interaction with FYNSH3 domain."; /evidence="ECO:0000269|PubMed:12545173"; MUTAGEN 74..75; /note="KR->AA: Disrupts interaction with FYNSH3 domain."; /evidence="ECO:0000269|PubMed:12545173"; MUTAGEN 78..79; /note="RK->AA: Disrupts interaction with FYNSH3 domain."; /evidence="ECO:0000269|PubMed:12545173"; MUTAGEN 78; /note="R->A: No effect on NK cell development, impairs promotion of NK cell cytotoxicity and IFN-gamma production in response to hematopoietic cells."; /evidence="ECO:0000269|PubMed:22683124"; MUTAGEN 90; /note="P->K: No effect on interaction with FYNSH3 domain."; /evidence="ECO:0000269|PubMed:12545173
uniprot
proteins
pubmed
10970095
uniprot
proteins
pubmed
12545173
uniprot
proteins
pubmed
16223723
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19648922
uniprot
proteins
pubmed
20962259
uniprot
proteins
pubmed
21219180
uniprot
proteins
pubmed
22683124
uniprot
proteins
pubmed
9774102
uniprot
proteins
sequence_length
126
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins