Q64709
uniprot
Q64709
canonical
amino_acid_sequence
MEKMSRQLPLNPTFIPPPYGVLRSLLENPLKLPLHPEDAFSKDRDKGKKLDDGSNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSTAPSVMDLSSRATAPLHPGIPSPNCMQNPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLALSSIPGPEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL
uniprot
proteins
function
FUNCTION: Transcription factor which selectively binds with high affinity to the consensus sequence 5'-GTTACGTAAT-3' and to closely related sites (By similarity). Has transcriptional activator activity (PubMed:7556072). Also has transcriptional repressor activity (By similarity). Binds to multiple sites in the promoter regions of coagulation factors F8 and F9 and activates transcription; transactivation activity is enhanced by formation of a heterodimer with DBP (By similarity). Binds to the promoter region of IRF2 and activates transcription (By similarity). Maintains quiescence of hematopoietic stem cells under steady-state conditions and protects the stem cell pool from toxic insults (By similarity). Regulates the tissue residency and proinflammatory function of CD4+ tissue-resident memory T (TRM) cells (By similarity). Down-regulates the expression of genes involved in promoting tissue egress of CD4+ TRM cells including S1PR1, KLF2 and TCF7 while up-regulating expression of tissue retention molecules such as CD69 (By similarity). Also up-regulates BHLHE40 expression, promoting proinflammatory cytokine production (By similarity). {ECO:0000250|UniProtKB:Q16534, ECO:0000250|UniProtKB:Q8BW74, ECO:0000269|PubMed:7556072}.
uniprot
proteins
mass_dalton
33114
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
PAR subfamily
uniprot
proteins
pubmed
7556072
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7556072}.
uniprot
proteins