Snap25
entrez
20614
canonical
uniprot
P60879
canonical
ensembl
ENSMUSG00000027273
resolver
ensp
ENSMUSP00000028727
resolver
ensp
ENSMUSP00000105725
resolver
ensp
ENSMUSP00000194391
resolver
ensp
ENSMUSP00000194394
resolver
ensp
ENSMUSP00000194396
resolver
ensp
ENSMUSP00000194398
resolver
ensp
ENSMUSP00000194420
resolver
ensp
ENSMUSP00000194424
resolver
ensp
ENSMUSP00000194431
resolver
genesymbol
Snap25
resolver
genesymbol_syn
Snap
resolver
uniprot
A2AIC2
resolver
uniprot
A2AIC3
resolver
uniprot
P13795
resolver
uniprot
P36974
resolver
uniprot
P70557
resolver
uniprot
P70558
resolver
uniprot
Q8IXK3
resolver
uniprot
Q96FM2
resolver
uniprot
Q9BR45
resolver
uniprot_entry
SNP25_MOUSE
resolver
uniprot_sec
A2AIC2
resolver
uniprot_sec
A2AIC3
resolver
uniprot_sec
P13795
resolver
uniprot_sec
P36974
resolver
uniprot_sec
P70557
resolver
uniprot_sec
P70558
resolver
uniprot_sec
Q8IXK3
resolver
uniprot_sec
Q96FM2
resolver
uniprot_sec
Q9BR45
resolver
amino_acid_sequence
MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNLTDLGKFCGLCVCPCNKLKSSDAYKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG
uniprot
proteins
function
FUNCTION: t-SNARE involved in the molecular regulation of neurotransmitter release (PubMed:8103915, PubMed:8243676). May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF (PubMed:16672379). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells (By similarity). {ECO:0000250|UniProtKB:P60881, ECO:0000269|PubMed:16672379, ECO:0000305|PubMed:8103915, ECO:0000305|PubMed:8243676}.
uniprot
proteins
mass_dalton
23315
uniprot
proteins
mutagenesis
MUTAGEN 85; /note="C->S: 91% reduction in palmitoylation level. 14% membrane association. No palmitoylation and less than 8% membrane association; when associated with S-88 or A-88."; /evidence="ECO:0000269|PubMed:9349529"; MUTAGEN 88; /note="C->S: 79% reduction in palmitoylation level. 18% membrane association. No palmitoylation and less than 8% membrane association; when associated with S-85 or A-85."; /evidence="ECO:0000269|PubMed:9349529"; MUTAGEN 90; /note="C->S: 58% reduction in palmitoylation level. 28% membrane association. Very little palmitoylation and less than 8% membrane association; when associated with S-92 or A-92."; /evidence="ECO:0000269|PubMed:9349529"; MUTAGEN 92; /note="C->S: 65% reduction in palmitoylation level. 29% membrane association. No palmitoylation and less than 8% membrane association; when associated with S-90 or A-90."; /evidence="ECO:0000269|PubMed:9349529
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association. {ECO:0000269|PubMed:9349529}.; PTM: (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type A (BoNT/A, botA) which hydrolyzes the 197-Gln-|-Arg-198 bond and inhibits neurotransmitter release (PubMed:8103915, PubMed:8243676). {ECO:0000269|PubMed:8243676, ECO:0000305|PubMed:10413679, ECO:0000305|PubMed:8103915}.; PTM: (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type E (BoNT/E) which hydrolyzes the 180-Arg-|-Ile-181 bond and inhibits neurotransmitter release (PubMed:8103915, PubMed:8243676). {ECO:0000269|PubMed:8243676, ECO:0000305|PubMed:10413679, ECO:0000305|PubMed:8103915}.
uniprot
proteins
protein_family
SNAP-25 family
uniprot
proteins
pubmed
10195194
uniprot
proteins
pubmed
10413679
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
12459461
uniprot
proteins
pubmed
15466855
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16672379
uniprot
proteins
pubmed
17055430
uniprot
proteins
pubmed
19196426
uniprot
proteins
pubmed
19285662
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19546860
uniprot
proteins
pubmed
20798282
uniprot
proteins
pubmed
20847230
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22832103
uniprot
proteins
pubmed
23341457
uniprot
proteins
pubmed
25253725
uniprot
proteins
pubmed
2592413
uniprot
proteins
pubmed
26198635
uniprot
proteins
pubmed
26406599
uniprot
proteins
pubmed
27052163
uniprot
proteins
pubmed
28821673
uniprot
proteins
pubmed
29056747
uniprot
proteins
pubmed
8103915
uniprot
proteins
pubmed
8243676
uniprot
proteins
pubmed
9349529
uniprot
proteins
pubmed
9731768
uniprot
proteins
sequence_length
206
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:16672379}. Cell membrane {ECO:0000269|PubMed:10413679, ECO:0000269|PubMed:9349529}; Lipid-anchor {ECO:0000269|PubMed:9349529}. Synapse, synaptosome {ECO:0000269|PubMed:2592413}. Photoreceptor inner segment {ECO:0000269|PubMed:26406599}. Note=Membrane association requires palmitoylation (PubMed:9349529). Expressed throughout cytoplasm, concentrating at the perinuclear region (PubMed:16672379). Colocalizes with KCNB1 at the cell membrane (By similarity). Colocalizes with PLCL1 at the cell membrane (By similarity). {ECO:0000250|UniProtKB:P60881, ECO:0000269|PubMed:16672379, ECO:0000269|PubMed:9349529}.
uniprot
proteins