PDE4DIP
entrez
9659
canonical
uniprot
Q5VU43
canonical
ensembl
ENSG00000178104
resolver
ensp
ENSP00000316434
resolver
ensp
ENSP00000358353
resolver
ensp
ENSP00000358355
resolver
ensp
ENSP00000358360
resolver
ensp
ENSP00000358363
resolver
ensp
ENSP00000433392
resolver
ensp
ENSP00000435920
resolver
ensp
ENSP00000436791
resolver
ensp
ENSP00000462316
resolver
ensp
ENSP00000479409
resolver
ensp
ENSP00000482121
resolver
ensp
ENSP00000512159
resolver
ensp
ENSP00000512160
resolver
ensp
ENSP00000512174
resolver
ensp
ENSP00000512175
resolver
ensp
ENSP00000516056
resolver
ensp
ENSP00000516481
resolver
ensp
ENSP00000670602
resolver
ensp
ENSP00000670603
resolver
ensp
ENSP00000670604
resolver
ensp
ENSP00000707961
resolver
ensp
ENSP00000707963
resolver
ensp
ENSP00000707967
resolver
ensp
ENSP00000770498
resolver
enst
ENST00000479408
resolver
enst
ENST00000585156
resolver
enst
ENST00000695768
resolver
enst
ENST00000695794
resolver
enst
ENST00000695795
resolver
enst
ENST00000704840
resolver
genesymbol
PDE4DIP
resolver
genesymbol_syn
CMYA2
resolver
genesymbol_syn
KIAA0454
resolver
genesymbol_syn
KIAA0477
resolver
genesymbol_syn
MMGL
resolver
hgnc
HGNC:15580
resolver
uniprot
A0A075B749
resolver
uniprot
A0A0A0MRM0
resolver
uniprot
A0A0C4DFQ0
resolver
uniprot
A0A8Q3SI21
resolver
uniprot
A0A8Q3SI83
resolver
uniprot
A0A8Q3WM32
resolver
uniprot
A0A994J5E0
resolver
uniprot
A2RU15
resolver
uniprot
E9PL24
resolver
uniprot
E9PQG4
resolver
uniprot
O75042
resolver
uniprot
O75065
resolver
uniprot
Q2YDC1
resolver
uniprot
Q5VU42
resolver
uniprot
Q5VU44
resolver
uniprot
Q5VU45
resolver
uniprot
Q5VU46
resolver
uniprot
Q5VU47
resolver
uniprot
Q5VU48
resolver
uniprot
Q5VU49
resolver
uniprot
Q68DU2
resolver
uniprot
Q6AZ93
resolver
uniprot
Q6PK88
resolver
uniprot
Q86T40
resolver
uniprot
Q86TB2
resolver
uniprot
Q8N3W0
resolver
uniprot
Q8TAY9
resolver
uniprot
Q9HCP2
resolver
uniprot
Q9HCP3
resolver
uniprot
Q9HCP4
resolver
uniprot
Q9HCP5
resolver
uniprot_entry
A0A075B749_HUMAN
resolver
uniprot_entry
A0A8Q3SI21_HUMAN
resolver
uniprot_entry
A0A8Q3SI83_HUMAN
resolver
uniprot_entry
A0A8Q3WM32_HUMAN
resolver
uniprot_entry
A0A994J5E0_HUMAN
resolver
uniprot_entry
E9PQG4_HUMAN
resolver
uniprot_entry
MYOME_HUMAN
resolver
uniprot_sec
A0A0A0MRM0
resolver
uniprot_sec
A0A0C4DFQ0
resolver
uniprot_sec
A2RU15
resolver
uniprot_sec
E9PL24
resolver
uniprot_sec
O75042
resolver
uniprot_sec
O75065
resolver
uniprot_sec
Q2YDC1
resolver
uniprot_sec
Q5VU42
resolver
uniprot_sec
Q5VU44
resolver
uniprot_sec
Q5VU45
resolver
uniprot_sec
Q5VU46
resolver
uniprot_sec
Q5VU47
resolver
uniprot_sec
Q5VU48
resolver
uniprot_sec
Q5VU49
resolver
uniprot_sec
Q68DU2
resolver
uniprot_sec
Q6AZ93
resolver
uniprot_sec
Q6PK88
resolver
uniprot_sec
Q86T40
resolver
uniprot_sec
Q86TB2
resolver
uniprot_sec
Q8N3W0
resolver
uniprot_sec
Q8TAY9
resolver
uniprot_sec
Q9HCP2
resolver
uniprot_sec
Q9HCP3
resolver
uniprot_sec
Q9HCP4
resolver
uniprot_sec
Q9HCP5
resolver
amino_acid_sequence
MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPRKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKLASLPQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGESASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDTSPVMKTPPKLEGDATDGSFANKHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIHELRSSTSALHHALEESASLLTMFWRAALPSTHIPVLPGKVGESTERELLELRTKVSKQERLLQSTTEHLKNANQQKESMEQFIVSQLTRTHDVLKKARTNLEVKSLRALPCTPAL
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving PDE4DIP may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP-PDGFRB fusion protein. {ECO:0000269|PubMed:12907457}.
uniprot
proteins
function
FUNCTION: Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). {ECO:0000250|UniProtKB:Q9WUJ3}.; FUNCTION: [Isoform 13]: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.
uniprot
proteins
mass_dalton
265103
uniprot
proteins
pubmed
11374908
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12907457
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25217626
uniprot
proteins
pubmed
27666745
uniprot
proteins
pubmed
28814570
uniprot
proteins
pubmed
29162697
uniprot
proteins
pubmed
9455484
uniprot
proteins
sequence_length
2346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:27666745}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9WUJ3}.; SUBCELLULAR LOCATION: [Isoform 13]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:29162697}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:29162697}. Golgi apparatus {ECO:0000269|PubMed:25217626}. Note=Associated with the microtubule network at the growing distal tip of microtubules (PubMed:29162697). Targeting to the Golgi apparatus requires AKAP9 (PubMed:25217626). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:29162697}.
uniprot
proteins