SCARB1
entrez
949
canonical
uniprot
Q8WTV0
canonical
ensembl
ENSG00000073060
resolver
ensp
ENSP00000261693
resolver
ensp
ENSP00000343795
resolver
ensp
ENSP00000414979
resolver
ensp
ENSP00000442862
resolver
ensp
ENSP00000444851
resolver
ensp
ENSP00000505757
resolver
ensp
ENSP00000547885
resolver
ensp
ENSP00000547886
resolver
ensp
ENSP00000547888
resolver
ensp
ENSP00000547892
resolver
ensp
ENSP00000606366
resolver
ensp
ENSP00000606371
resolver
ensp
ENSP00000634750
resolver
enst
ENST00000546215
resolver
enst
ENST00000680556
resolver
enst
ENST00000936307
resolver
enst
ENST00000964691
resolver
genesymbol
SCARB1
resolver
genesymbol_syn
CD36L1
resolver
genesymbol_syn
CLA1
resolver
hgnc
HGNC:1664
resolver
uniprot
A0A7P0Z4E3
resolver
uniprot
A0ACI8VGC6
resolver
uniprot
B3KW46
resolver
uniprot
B7ZKQ9
resolver
uniprot
F8W8N0
resolver
uniprot
Q14016
resolver
uniprot
Q52LZ5
resolver
uniprot
Q6KFX4
resolver
uniprot_entry
A0A7P0Z4E3_HUMAN
resolver
uniprot_entry
A0ACI8VGC6_HUMAN
resolver
uniprot_entry
B3KW46_HUMAN
resolver
uniprot_entry
B7ZKQ9_HUMAN
resolver
uniprot_entry
SCRB1_HUMAN
resolver
uniprot_sec
F8W8N0
resolver
uniprot_sec
Q14016
resolver
uniprot_sec
Q52LZ5
resolver
uniprot_sec
Q6KFX4
resolver
amino_acid_sequence
MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQRAARADSHSLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLEGLGPSLGGGTGS
uniprot
proteins
function
FUNCTION: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218). {ECO:0000269|PubMed:12016218, ECO:0000269|PubMed:12519372, ECO:0000269|PubMed:16020694, ECO:0000269|PubMed:21226579, ECO:0000269|PubMed:26965621}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718). {ECO:0000269|PubMed:12356718, ECO:0000269|PubMed:18000990}.; FUNCTION: (Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus. {ECO:0000269|PubMed:16020694}.; FUNCTION: (Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding. {ECO:0000269|PubMed:33244168}.
uniprot
proteins
mass_dalton
60878
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:12016218, ECO:0000269|PubMed:19159218}.; PTM: The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds. {ECO:0000250|UniProtKB:Q61009}.
uniprot
proteins
protein_family
CD36 family
uniprot
proteins
pubmed
12016218
uniprot
proteins
pubmed
12356718
uniprot
proteins
pubmed
12519372
uniprot
proteins
pubmed
12913001
uniprot
proteins
pubmed
12966036
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16020694
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
18000990
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
20686565
uniprot
proteins
pubmed
21226579
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26965621
uniprot
proteins
pubmed
33244168
uniprot
proteins
pubmed
7689561
uniprot
proteins
pubmed
9254074
uniprot
proteins
pubmed
9614139
uniprot
proteins
sequence_length
552
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26965621}; Multi-pass membrane protein. Membrane, caveola {ECO:0000250|UniProtKB:Q61009}; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 444..464; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins