EPHA7
entrez
2045
canonical
uniprot
Q15375
canonical
ensembl
ENSG00000135333
resolver
ensp
ENSP00000358303
resolver
ensp
ENSP00000358309
resolver
ensp
ENSP00000505682
resolver
ensp
ENSP00000505741
resolver
ensp
ENSP00000505801
resolver
ensp
ENSP00000505937
resolver
ensp
ENSP00000506130
resolver
ensp
ENSP00000538272
resolver
ensp
ENSP00000538273
resolver
ensp
ENSP00000785641
resolver
enst
ENST00000680190
resolver
enst
ENST00000680953
resolver
enst
ENST00000681130
resolver
enst
ENST00000681532
resolver
genesymbol
EPHA7
resolver
genesymbol_syn
EHK3
resolver
genesymbol_syn
HEK11
resolver
hgnc
HGNC:3390
resolver
uniprot
A0A7P0T9G1
resolver
uniprot
A0A7P0T9L5
resolver
uniprot
A0A7P0T9V9
resolver
uniprot
A0A7P0TA58
resolver
uniprot
A0AUX7
resolver
uniprot
B2R8W1
resolver
uniprot
B7ZLJ9
resolver
uniprot
B7ZLK0
resolver
uniprot
Q59G40
resolver
uniprot
Q5VTU0
resolver
uniprot
Q8N368
resolver
uniprot
Q9H124
resolver
uniprot_entry
A0A7P0T9G1_HUMAN
resolver
uniprot_entry
A0A7P0T9L5_HUMAN
resolver
uniprot_entry
A0A7P0T9V9_HUMAN
resolver
uniprot_entry
A0A7P0TA58_HUMAN
resolver
uniprot_entry
EPHA7_HUMAN
resolver
uniprot_sec
A0AUX7
resolver
uniprot_sec
B2R8W1
resolver
uniprot_sec
B7ZLJ9
resolver
uniprot_sec
B7ZLK0
resolver
uniprot_sec
Q59G40
resolver
uniprot_sec
Q5VTU0
resolver
uniprot_sec
Q8N368
resolver
uniprot_sec
Q9H124
resolver
amino_acid_sequence
MVFQTRYPSWIILCYIWLLRFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPNGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRTNWISKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKKGFYLAFQDVGACIALVSVKVYYKKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVSSAEEEAENAPRMHCSAEGEWLVPIGKCICKAGYQQKGDTCEPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECEDGYYRAPSDPPYVACTRPPSAPQNLIFNINQTTVSLEWSPPADNGGRNDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAAPSQVSGVMKERVLQRSVELSWQEPEHPNGVITEYEIKYYEKDQRERTYSTVKTKSTSASINNLKPGTVYVFQIRAFTAAGYGNYSPRLDVATLEEATGKMFEATAVSSEQNPVIIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDEELYFHFKFPGTKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIRNPNSLKTPLGTCSRPISPLLDQNTPDFTTFCSVGEWLQAIKMERYKDNFTAAGYNSLESVARMTIEDVMSLGITLVGHQKKIMSSIQTMRAQMLHLHGTGIQV
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7. {ECO:0000269|PubMed:17726105}.
uniprot
proteins
mass_dalton
112097
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
Ephrin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17726105
uniprot
proteins
pubmed
20126984
uniprot
proteins
pubmed
7898931
uniprot
proteins
pubmed
9267020
uniprot
proteins
sequence_length
998
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 556..576; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins