RNF182
entrez
221687
canonical
uniprot
Q8N6D2
canonical
ensembl
ENSG00000180537
resolver
ensp
ENSP00000420465
resolver
ensp
ENSP00000441271
resolver
ensp
ENSP00000442021
resolver
ensp
ENSP00000443228
resolver
ensp
ENSP00000537900
resolver
ensp
ENSP00000537901
resolver
ensp
ENSP00000583298
resolver
ensp
ENSP00000583299
resolver
ensp
ENSP00000583300
resolver
ensp
ENSP00000628765
resolver
enst
ENST00000488300
resolver
enst
ENST00000537388
resolver
enst
ENST00000537663
resolver
enst
ENST00000544682
resolver
enst
ENST00000867841
resolver
enst
ENST00000867842
resolver
enst
ENST00000913239
resolver
enst
ENST00000913240
resolver
enst
ENST00000913241
resolver
enst
ENST00000958706
resolver
genesymbol
RNF182
resolver
hgnc
HGNC:28522
resolver
uniprot
B2RDG2
resolver
uniprot
Q8NBG3
resolver
uniprot_entry
RN182_HUMAN
resolver
uniprot_sec
B2RDG2
resolver
uniprot_sec
Q8NBG3
resolver
amino_acid_sequence
MASQPPEDTAESQASDELECKICYNRYNLKQRKPKVLECCHRVCAKCLYKIIDFGDSPQGVIVCPFCRFETCLPDDEVSSLPDDNNILVNLTCGGKGKKCLPENPTELLLTPKRLASLVSPSHTSSNCLVITIMEVQRESSPSLSSTPVVEFYRPASFDSVTTVSHNWTVWNCTSLLFQTSIRVLVWLLGLLYFSSLPLGIYLLVSKKVTLGVVFVSLVPSSLVILMVYGFCQCVCHEFLDCMAPPS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway (PubMed:18298843). Also plays a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA (PubMed:31432514). {ECO:0000269|PubMed:18298843, ECO:0000269|PubMed:31432514}.
uniprot
proteins
mass_dalton
27402
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:18298843}.
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18298843
uniprot
proteins
pubmed
31432514
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:18298843, ECO:0000269|PubMed:31432514}.
uniprot
proteins
transmembrane_region
TRANSMEM 184..204; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins