SMYD3
entrez
64754
canonical
uniprot
Q9H7B4
canonical
ensembl
ENSG00000185420
resolver
ensp
ENSP00000419184
resolver
ensp
ENSP00000487434
resolver
genesymbol
SMYD3
resolver
genesymbol_syn
ZMYND1
resolver
genesymbol_syn
ZNFN3A1
resolver
hgnc
HGNC:15513
resolver
uniprot
A0A024R5P8
resolver
uniprot
A8K0P0
resolver
uniprot
B1AN38
resolver
uniprot
B3KN46
resolver
uniprot
Q86TL8
resolver
uniprot
Q8N5Z6
resolver
uniprot
Q96AI5
resolver
uniprot_entry
B3KN46_HUMAN
resolver
uniprot_entry
SMYD3_HUMAN
resolver
uniprot_sec
A0A024R5P8
resolver
uniprot_sec
A8K0P0
resolver
uniprot_sec
B1AN38
resolver
uniprot_sec
Q86TL8
resolver
uniprot_sec
Q8N5Z6
resolver
uniprot_sec
Q96AI5
resolver
activity_regulation
ACTIVITY REGULATION: Histone methyltransferase activity strongly stimulated by HSPCA. {ECO:0000269|PubMed:15235609}.
uniprot
proteins
amino_acid_sequence
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS
uniprot
proteins
ec_number
2.1.1.354
uniprot
proteins
function
FUNCTION: Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068). Also methylates 'Lys-5' of histone H4 (PubMed:22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609). {ECO:0000269|PubMed:15235609, ECO:0000269|PubMed:22419068}.
uniprot
proteins
mass_dalton
49097
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15235609
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22419068
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25738358
uniprot
proteins
sequence_length
428
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15235609}. Nucleus {ECO:0000269|PubMed:15235609, ECO:0000269|PubMed:25738358}. Note=Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M. {ECO:0000269|PubMed:15235609}.
uniprot
proteins