PSMA6
entrez
5687
canonical
uniprot
P60900
canonical
ensembl
ENSG00000100902
resolver
ensp
ENSP00000261479
resolver
ensp
ENSP00000444844
resolver
ensp
ENSP00000452566
resolver
ensp
ENSP00000479620
resolver
genesymbol
PSMA6
resolver
genesymbol_syn
PROS27
resolver
hgnc
HGNC:9535
resolver
uniprot
A0A140VK44
resolver
uniprot
B2R7J9
resolver
uniprot
B4DQR4
resolver
uniprot
B4DXJ9
resolver
uniprot
P34062
resolver
uniprot
Q6IB60
resolver
uniprot_entry
A0A140VK44_HUMAN
resolver
uniprot_entry
PSA6_HUMAN
resolver
uniprot_sec
B2R7J9
resolver
uniprot_sec
B4DQR4
resolver
uniprot_sec
B4DXJ9
resolver
uniprot_sec
P34062
resolver
uniprot_sec
Q6IB60
resolver
amino_acid_sequence
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
uniprot
proteins
mass_dalton
27399
uniprot
proteins
protein_family
Peptidase T1A family
uniprot
proteins
pubmed
12181345
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15244466
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
1888762
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23145062
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23495936
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25599644
uniprot
proteins
pubmed
26133119
uniprot
proteins
pubmed
27176742
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
27493187
uniprot
proteins
pubmed
34711951
uniprot
proteins
pubmed
7681138
uniprot
proteins
pubmed
7811265
uniprot
proteins
pubmed
8610016
uniprot
proteins
sequence_length
246
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QUM9, ECO:0000269|PubMed:12181345}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (PubMed:34711951). Colocalizes with TRIM5 in cytoplasmic bodies (By similarity). {ECO:0000250|UniProtKB:Q9QUM9, ECO:0000269|PubMed:34711951}.
uniprot
proteins