Clec4a
entrez
26888
canonical
uniprot
Q9QZ15
canonical
ensembl
ENSMUSG00000030148
resolver
ensp
ENSMUSP00000032248
resolver
ensp
ENSMUSP00000045781
resolver
ensp
ENSMUSP00000124615
resolver
ensp
ENSMUSP00000288218
resolver
enst
ENSMUST00000032248
resolver
enst
ENSMUST00000041779
resolver
enst
ENSMUST00000161365
resolver
genesymbol
Clec4a
resolver
genesymbol
Clec4a2
resolver
genesymbol_syn
Clec4a2
resolver
genesymbol_syn
Clecsf6
resolver
genesymbol_syn
Dcir
resolver
uniprot
F8WJ97
resolver
uniprot
Q4VA33
resolver
uniprot
Q923C7
resolver
uniprot_entry
CLC4A_MOUSE
resolver
uniprot_entry
F8WJ97_MOUSE
resolver
uniprot_entry
Q923C7_MOUSE
resolver
uniprot_sec
Q4VA33
resolver
amino_acid_sequence
MASEITYAEVKFKNESNSLHTYSESPAAPREKPIRDLRKPGSPSLLLTSLMLLLLLLAITFLVAFIIYFQKYSQLLEEKKAAKNIMHNELNCTKSVSPMEDKVWSCCPKDWRLFGSHCYLVPTVSSSASWNKSEENCSRMGAHLVVIQSQEEQDFITGILDTHAAYFIGLWDTGHRQWQWVDQTPYEESITFWHNGEPSSGNEKCATIIYRWKTGWGWNDISCSLKQKSVCQMKKINL
uniprot
proteins
function
FUNCTION: May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. {ECO:0000250, ECO:0000269|PubMed:11841542}.; FUNCTION: C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production (By similarity). May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation (PubMed:11841542). {ECO:0000250|UniProtKB:Q9UMR7, ECO:0000269|PubMed:11841542}.
uniprot
proteins
mass_dalton
27323
uniprot
proteins
mutagenesis
MUTAGEN 7; /note="Y->F: Loss of inhibition of B-cell calcium mobilization."; /evidence="ECO:0000269|PubMed:11841542
uniprot
proteins
pubmed
10438934
uniprot
proteins
pubmed
11841542
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
sequence_length
238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9UMR7}; Extracellular side {ECO:0000250|UniProtKB:Q9UMR7}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins