Ripor2
entrez
193385
canonical
uniprot
Q80U16
canonical
ensembl
ENSMUSG00000036006
resolver
ensp
ENSMUSP00000043663
resolver
ensp
ENSMUSP00000089286
resolver
ensp
ENSMUSP00000106012
resolver
ensp
ENSMUSP00000106013
resolver
ensp
ENSMUSP00000159186
resolver
ensp
ENSMUSP00000233694
resolver
ensp
ENSMUSP00000233697
resolver
ensp
ENSMUSP00000233705
resolver
enst
ENSMUST00000110383
resolver
enst
ENSMUST00000238974
resolver
genesymbol
Ripor2
resolver
genesymbol_syn
Fam65b
resolver
genesymbol_syn
Kiaa0386
resolver
uniprot
A0A5F8MPY8
resolver
uniprot
A6PW01
resolver
uniprot
A6PW03
resolver
uniprot
A6PW28
resolver
uniprot
Q3TQ58
resolver
uniprot
Q5SY29
resolver
uniprot
Q5SZV4
resolver
uniprot
Q5T0J1
resolver
uniprot
Q8BIM7
resolver
uniprot
Q8BJ19
resolver
uniprot
Q8BJ22
resolver
uniprot
Q8BJ32
resolver
uniprot
Q8BJ54
resolver
uniprot_entry
A0A5F8MPY8_MOUSE
resolver
uniprot_entry
A6PW28_MOUSE
resolver
uniprot_entry
RIPR2_MOUSE
resolver
uniprot_sec
A6PW01
resolver
uniprot_sec
A6PW03
resolver
uniprot_sec
Q3TQ58
resolver
uniprot_sec
Q5SY29
resolver
uniprot_sec
Q5SZV4
resolver
uniprot_sec
Q5T0J1
resolver
uniprot_sec
Q8BIM7
resolver
uniprot_sec
Q8BJ19
resolver
uniprot_sec
Q8BJ22
resolver
uniprot_sec
Q8BJ32
resolver
uniprot_sec
Q8BJ54
resolver
amino_acid_sequence
MPPGTKRLRALGAFSAGLPTRLPEIMLVGSQSFSPGGPNGIIRSQSFAGFSGLQERRSRCNSFIENASALKKPQAKLKKMHNLGHKNNNTPKEPQPKRVEEVYRALKNGLDEYLEFHQTELDKLTAQLKDMKRNSRLGVLYDLDKQIKTIERYMRRLEFHISKVDELYEAYCIQRRLQDGASKMKQAFATSPASKAARESLSEINRSYKEYTENMCAIEAELESLLGEFSIKMKGLAGFARLCPGDQYEIFMKYGRQRWKLKGKIEVNGKQSWDGAETVFLPLIVGFISIKVTELKGLATHILVGSVTCETKELFAARPQVVAVDINDLGTIKLNLEITWYPFDVEDTTPSSGPGNKTAALQRRMSMYSQGTPETPTFKDQSFFRWLRLSVLSALRDTFFATLHHNHSVGDLPSLSLNPKALLEFYSNLPDDIFESGKAAEEKRPLSLSFSDLQDGDCVFTSSSATSPSSSHSAHPEITITPAELTHSSLSSQNEGTEDSSSASSRNSLGEDHEPKSHPKSDTVEPGKPGVATRSGTESLFLESSVAEALLQESDEASELKPVELDTFEGNITKQLVKRLTSAEGPVTTDKLFFEGSVGSESEAGRSFLDGSLEDAFNGLFLALDPHKKQYKEFQDLNQEVTHLDDVLKCKPAGSRSRSSSLSLTVESALESFDFLNTSDFDEEEEDGDDVCHVGGGADSVFSDTETEKSGYRSVHPEARGHLSEALTEDTGVGTSVAGSPLPLTTGNESLDITIVKHLQYCTQLIQQIVFSSKTPFVARSLLEKLSRQVLVMQKLAAVSDENLGNITSVVEAIPEFHKKLSLLAFWTKCCSPSGVYHSSAARLIKQLEASFARSINKDYPGLAEPVFRTLVSQILDRAEPLLSSSLSSEVITVFQYYSFFTSHGVSDLETYLGQLTRQVAMVQTLQSLRDEKLLQTMSDLAPSNLPAQQEVLRTLALLLTRDDNEVSEAVTLYLAAASKNEHFREKALLYYCEALTKANLQLQKAACLALKSLEATESIKMLVTLCQSDTEEIRTVASETLLSLGEDGRLAYEQLDKFPRDCVKVGGRHGTEVATAF
uniprot
proteins
function
FUNCTION: Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:25588844, PubMed:27269051). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (By similarity). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (PubMed:25588844). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (PubMed:27269051). Plays a role for maintaining the structural organization of the basal domain of stereocilia (PubMed:27269051). Involved in mechanosensory hair cell function (PubMed:27269051). Required for normal hearing (PubMed:27269051). {ECO:0000250|UniProtKB:Q9Y4F9, ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:25588844, ECO:0000269|PubMed:27269051}.
uniprot
proteins
mass_dalton
118970
uniprot
proteins
mutagenesis
MUTAGEN 176..177; /note="RL->AA: Inhibits interaction with RHOC. Reduces homooligomerization activity. Inhibits RHOC-dependent homooligomerization activity. Abolishes ability to rescue the morphological hair bundle defect in hair cell of RIPOR2-deficient mice."; /evidence="ECO:0000269|PubMed:27269051"; MUTAGEN 575..578; /note="Missing: Loss of retention in the stereocilia, but does not visibly affect the stereocilia structure in the short term. Contrary to wild-type, does not rescue the morphological defects observed in hair cells of knockout mice, which include hair bundle polarity and cohesion and length of stereocilia."; /evidence="ECO:0000269|PubMed:32631815
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Chemokine-induced phosphorylation in neutrophils occurs in a PKC- and AKT-dependent manner, resulting in RIPOR2 interaction with YWHAB and stabilization. Phosphorylated by PKCA, AKT1 and MAPKAPK1A; in vitro. {ECO:0000250|UniProtKB:Q9Y4F9}.
uniprot
proteins
protein_family
RIPOR family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17150207
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24687993
uniprot
proteins
pubmed
24958875
uniprot
proteins
pubmed
25588844
uniprot
proteins
pubmed
27269051
uniprot
proteins
pubmed
32631815
uniprot
proteins
sequence_length
1078
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y4F9}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9Y4F9}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9Y4F9}. Cell projection, stereocilium {ECO:0000269|PubMed:27269051, ECO:0000269|PubMed:32631815}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q7TP54}. Apical cell membrane {ECO:0000250|UniProtKB:Q7TP54}. Note=Localized in the cytoplasm in cells undergoing mitosis (By similarity). Colocalized with F-actin (By similarity). Accumulates at the leading edge of polarized neutrophils in a chemokine-dependent manner (By similarity). Localized with RHOC within the basal domain of hair cell stereocilia, near the taper region (PubMed:27269051). Detected in punctate pattern forming a circumferential ring at the stereocilia base (PubMed:27269051). Localized to the apical stereocilia of inner and outer hair cells (By similarity). Not detected as a membrane-associated protein in stereocilia (PubMed:27269051). {ECO:0000250|UniProtKB:Q9Y4F9, ECO:0000269|PubMed:27269051}.
uniprot
proteins