Spsb1
entrez
74646
canonical
uniprot
Q9D5L7
canonical
ensembl
ENSMUSG00000039911
resolver
ensp
ENSMUSP00000048969
resolver
ensp
ENSMUSP00000101310
resolver
ensp
ENSMUSP00000170865
resolver
genesymbol
Spsb1
resolver
genesymbol_syn
Ssb1
resolver
uniprot
Q5FWI0
resolver
uniprot
Q8BJA4
resolver
uniprot_entry
SPSB1_MOUSE
resolver
uniprot_sec
Q5FWI0
resolver
uniprot_sec
Q8BJA4
resolver
amino_acid_sequence
MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGKERLGAIPALPLPASLKAYLLYQ
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links the NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). {ECO:0000250|UniProtKB:Q96BD6}.
uniprot
proteins
mass_dalton
30785
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
SPSB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16369487
uniprot
proteins
pubmed
16498413
uniprot
proteins
pubmed
20561531
uniprot
proteins
pubmed
20603330
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q96BD6}. Note=Exhibits a diffuse cytosolic localization. {ECO:0000250|UniProtKB:Q96BD6}.
uniprot
proteins