Npr3
entrez
18162
canonical
uniprot
P70180
canonical
ensembl
ENSMUSG00000022206
resolver
ensp
ENSMUSP00000066737
resolver
ensp
ENSMUSP00000153895
resolver
ensp
ENSMUSP00000154180
resolver
enst
ENSMUST00000066529
resolver
enst
ENSMUST00000228489
resolver
enst
ENSMUST00000228603
resolver
genesymbol
Npr3
resolver
uniprot
A0A2I3BPR9
resolver
uniprot
A0A2I3BQI2
resolver
uniprot
G3X9E5
resolver
uniprot
P97804
resolver
uniprot
Q7TMG7
resolver
uniprot
Q9R025
resolver
uniprot
Q9R027
resolver
uniprot
Q9R028
resolver
uniprot_entry
A0A2I3BPR9_MOUSE
resolver
uniprot_entry
A0A2I3BQI2_MOUSE
resolver
uniprot_entry
ANPRC_MOUSE
resolver
uniprot_entry
Q7TMG7_MOUSE
resolver
uniprot_sec
G3X9E5
resolver
uniprot_sec
P97804
resolver
uniprot_sec
Q9R025
resolver
uniprot_sec
Q9R027
resolver
uniprot_sec
Q9R028
resolver
amino_acid_sequence
MRSLLLFTFSACVLLARVLLAGGASSGAGDTRPGSRRRAREALAAQKIEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTSGDYAFFNIELFNSSSYGDGSWRRGDKHDSEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFQMRSNVKYPWGPLKLRLDETRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNQQEESNIGKHRELREDSIRSHFSVA
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Npr3 are the cause of a number of skeletal-overgrowth phenotypes, Longjohn (Lgj), Longjohn-2J (Lgj-2J) and Strigosus (Stri). These are all recessive conditions characterized by an elongated body, thoracic kyphosis, arachnodactyly, and sacral and/or tail kinks, but no significant changes in craniofacial structures (PubMed:10468599). {ECO:0000269|PubMed:10468599}.
uniprot
proteins
function
FUNCTION: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP (PubMed:10377427, PubMed:17951249). May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects (PubMed:10377427, PubMed:17951249). Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (PubMed:14523025, PubMed:19244276). {ECO:0000269|PubMed:10377427, ECO:0000269|PubMed:14523025, ECO:0000269|PubMed:17951249, ECO:0000269|PubMed:19244276}.
uniprot
proteins
mass_dalton
59808
uniprot
proteins
protein_family
ANF receptor family
uniprot
proteins
pubmed
10377427
uniprot
proteins
pubmed
10468599
uniprot
proteins
pubmed
14523025
uniprot
proteins
pubmed
17951249
uniprot
proteins
pubmed
19244276
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8620881
uniprot
proteins
pubmed
9032278
uniprot
proteins
sequence_length
536
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P17342}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 479..499; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins