Abcc6
entrez
81642
canonical
uniprot
O88269
canonical
ensembl
ENSRNOG00000028781
resolver
ensembl
ENSRNOG00055006747
resolver
ensembl
ENSRNOG00060011166
resolver
ensembl
ENSRNOG00065031913
resolver
ensp
ENSRNOP00000051412
resolver
ensp
ENSRNOP00055008620
resolver
ensp
ENSRNOP00060014710
resolver
ensp
ENSRNOP00065045224
resolver
enst
ENSRNOT00000042115
resolver
enst
ENSRNOT00055011036
resolver
enst
ENSRNOT00060018875
resolver
enst
ENSRNOT00065054982
resolver
genesymbol
Abcc6
resolver
genesymbol_syn
Mlp1
resolver
genesymbol_syn
Mrp6
resolver
uniprot_entry
MRP6_RAT
resolver
amino_acid_sequence
MNGEHSMATPGESCAGLRVWNQTEQEPVAYHLLNLCFLRAAGSWVPPMYLWVLGPIYLLYIHRHGCCYLRMSRLFKIKMVLGFALILLYTFNAAVPLWRIHRGMPQAPELLIHPTVWLTTMSFATFLIHMERKKGVRASGLLFGYWLLCCLVPAIDTVQQASAGSFRQEPLHHLATYLCLSLVVAELVLSCLVDQPPFFSEDSKPLNPCPEAEASFPSKAMFWWASGLLWKGYRKLLGPKDLWSLERENSSEELVSQLEREWRRNFSELPGHKGHSGMGTPETEAFLQPERSQRGPLLRAIWRVFRSTFLLGTLSLVISDAFRFAVPKLLSLFLEFMGDLESSAWTGWLLAVLMFLSACLQTLFEQQYMYRVKVLQMRLRTAITGLVYRKVLVLSSGSRKSSAAGDVVNLVSVDVQRLVESILHLNGLWLLFLWIIVCFVYLWQLLGPSALTAVAVFLSLLPLNFFITKKRSFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWECAFLERLLHIRGQELGALKTSAFLFSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQAFLPFSVHCLVQARVSFDRLAAFLCLEEVDPNGMVLSPSRCSSKDRISIHNGTFAWSQESPPCLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGSVAYVPQEAWVQNTSVVENVCFRQELDLPWLQEVLEACALGSDVASFPAGVHTPVGEQGMNLSGGQKQRLSLARAVYRRAAVYLMDDPLAALDAHVSQEVFKQVIGPSGLLQGTTRILVTHTLHVLPQADQILVLANGTIAEMGSYQDLLHRNGALVGLLDGARQPAGEGEGEAHAAATSDDLGGFSGGGTPTRRPERPRPSDAAPVKGSTSEAQMEPSLDDVEVTGLTAGEDSVQYGRVKSATYLSYLRAVGTPLCTYTLFLFLCQQVASFCQGYWLSLWADDPVVDGKQMHSALRGSIFGLLGCLQAIGLFASMAAVFLGGARASCLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDIVDVDIPDKMRTLLTYAFGLLEVGLAVSMATPLAIVAILPLMLLYAGFQSLYVATCCQLRRLESASYSSVCSHLAETFQGSQVVRAFQAQGPFTAQHDALMDENQRISFPRLVADRWLAANLELLGNGLVFVAATCAVLSKAHLSAGLAGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYVHTPKEAPWRLPSSAAQPLWPCGGQIEFRDFGLRHRPELPMAVQGVSLKIHAGEKVGIVGRTGAGKSSLTWGLLRLQEATEGGIWIDGVPITDMGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQENTDEGIWAALETVQLKAFVTSLPGQLQYECSGQGDDLSVGQKQLLCLARALLRKTQILILDEATASVDPGTEIQMQAALERWFAQCTVLLIAHRLRSVMNCARVLVMDEGQVAESGSPAQLLAQKGLFYRLAQESGLA
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
ec_number
7.6.2.3
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro) (By similarity). Also transports an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed:10692506). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity). {ECO:0000250|UniProtKB:O95255, ECO:0000269|PubMed:10692506}.; FUNCTION: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. {ECO:0000269|PubMed:28111129, ECO:0000269|PubMed:33058196}.
uniprot
proteins
mass_dalton
164995
uniprot
proteins
mutagenesis
MUTAGEN 1426; /note="E->Q: Does not affect plasma membrane localization. Abolishes cellular ATP release."; /evidence="ECO:0000269|PubMed:33058196
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:O95255}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCC family
uniprot
proteins
protein_family
Conjugate transporter (TC 3.A.1.208) subfamily
uniprot
proteins
pubmed
10692506
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
28111129
uniprot
proteins
pubmed
33058196
uniprot
proteins
pubmed
9614210
uniprot
proteins
sequence_length
1502
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:10692506, ECO:0000269|PubMed:28111129}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:33058196}; Multi-pass membrane protein {ECO:0000255}. Lateral cell membrane {ECO:0000269|PubMed:10692506}; Multi-pass membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000250|UniProtKB:O95255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical; Name=1"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 79..99; /note="Helical; Name=2"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 105..125; /note="Helical; Name=3"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 138..155; /note="Helical; Name=4"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 174..194; /note="Helical; Name=5"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 301..321; /note="Helical; Name=6"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 348..368; /note="Helical; Name=7"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 425..445; /note="Helical; Name=8"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 449..469; /note="Helical; Name=9"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 532..552; /note="Helical; Name=10"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 575..595; /note="Helical; Name=11"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 939..959; /note="Helical; Name=12"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 997..1017; /note="Helical; Name=13"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1061..1081; /note="Helical; Name=14"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1083..1103; /note="Helical; Name=15"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1175..1195; /note="Helical; Name=16"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1198..1218; /note="Helical; Name=17"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins