Q3TD16
uniprot
Q3TD16
canonical
amino_acid_sequence
MVSQSIGWGDSPVDLCEGSNRAFQDTDQPACQLDVRLLRHKASWINPLCVQQPLQELCPQRPTVQSSENHVVLDTPSPLRLSILSYRDSLAEMPLSENTADVICSNSAHCSGGKEGDFFLATEEQEVHLQQESLLKNPKTVATSPSPKEGSARSESPHLTASTDDGDARSSSRSHAWNFFPLETFMLPADVEKENLHFYAADIIISVIENMKCNLPNQQQPERWDTEDASRLRGTGAEMTFYTHIKQEPGSSASSHTGCEGCAALQVSPVAETLSYCPVAGEACKHDLNKLVMLELGKYNDITKGCRCSYNSSKSATCESNLSPAGCLARELFRGFCKCWMLSEVNCQLPGSPTTASSGVGDEEYAEEDFDSSVDAAREVMLKSRVPGTEDWVLPRCQIILTVHPPIKRDIAVVAQNFFCAGCGTPIQPKFVKRLRYCEYLGKYFCASCHSSAESCIPARILTMWDFRKYQVSDFSKWLLDSVWHQPVFKLLGGHHSLYAKAKELDRVKDLQEQLFHIKKLLKTCRFADSVLKEFEQVPSHLTDECHIFSMDDFLRTKKGLLAPLLKDILRASLAHVDSCELCQGKGFICEFCQSTTVIFPFQTTTCRRCAACRACFHKQCFQSSRCPRCARIIARRQHLESLPTAAT
uniprot
proteins
function
FUNCTION: Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (By similarity). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (By similarity). Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (By similarity). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (PubMed:30704899). May act as a tumor suppressor (By similarity). {ECO:0000250|UniProtKB:Q9H714, ECO:0000269|PubMed:30704899}.
uniprot
proteins
mass_dalton
72279
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MTOR at Ser-144 under nutrient-rich conditions. Phosphorylation prevents acetylation by KAT5/TIP60 and impairs RUBCNL/PACER function and autophagosome maturation. Under autophagy induction, Phosphorylation by MTOR is repressed, enabling acetylation by KAT5/TIP60. {ECO:0000250|UniProtKB:Q9H714}.; PTM: Acetylated by KAT5/TIP60 under autophagy induction, promoting autophagosome maturation and lipid metabolism (PubMed:30704899). Acetylation is prevented by phosphorylation by MTOR (By similarity). Lys-469 and Lys-559 constitute the key sites for tuning function in autophagy (By similarity). {ECO:0000250|UniProtKB:Q9H714, ECO:0000269|PubMed:30704899}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30704899
uniprot
proteins
sequence_length
648
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q9H714}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H714}. Note=Associates with late autophagic structure. Recruitment to autophagosome membrane is promoted by autophagic stimuli. {ECO:0000250|UniProtKB:Q9H714}.
uniprot
proteins