E2f4
entrez
104394
canonical
uniprot
Q8R0K9
canonical
ensembl
ENSMUSG00000014859
resolver
ensp
ENSMUSP00000015003
resolver
enst
ENSMUST00000015003
resolver
genesymbol
E2f4
resolver
uniprot
Q8R2X6
resolver
uniprot_entry
E2F4_MOUSE
resolver
uniprot_sec
Q8R2X6
resolver
amino_acid_sequence
MAEAGPQAPPPPGTPSRHEKSLGLLTTKFVSLLQEAKDGVLDLKLAADTLAVRQKRRIYDITNVLEGIGLIEKKSKNSIQWKGVGPGCNTREIADKLIELKAEIEELQQREQELDQHKVWVQQSIRNVTEDVQNSCLAYVTHEDICRCFAGDTLLAIRAPSGTSLEVPIPEGLNGQKKYQIHLKSMSGPIEVLLVNKEAWSSPPVAVPVPPPDDLLQSPPAVSTPPPLPKPALAQPQESSPPSSPQLTTPTPVLGSTQVSEVACQTSEIAVSGSPGTENKDSGEVSSLPLGLTALDTRPLQSSALLDSSSSSSSSSSSSSSSSSGPNPSTSFEPIKADPTGVLDLPKELSEIFDPTRECMSSELLEELMSSEVFAPLLRLSPPPGDHDYIYNLDESEGVCDLFDVPVLKL
uniprot
proteins
function
FUNCTION: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q16254, ECO:0000250|UniProtKB:Q6DE14, ECO:0000269|PubMed:17383628}.
uniprot
proteins
mass_dalton
43833
uniprot
proteins
post_translational_modification
PTM: Differentially phosphorylated in vivo. {ECO:0000250}.
uniprot
proteins
protein_family
E2F/DP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17383628
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q16254}.
uniprot
proteins