GPR146
entrez
115330
canonical
uniprot
Q96CH1
canonical
ensembl
ENSG00000164849
resolver
ensp
ENSP00000380283
resolver
ensp
ENSP00000410743
resolver
ensp
ENSP00000523375
resolver
ensp
ENSP00000523376
resolver
ensp
ENSP00000523377
resolver
ensp
ENSP00000523378
resolver
ensp
ENSP00000523379
resolver
ensp
ENSP00000523380
resolver
ensp
ENSP00000523381
resolver
ensp
ENSP00000523382
resolver
ensp
ENSP00000523383
resolver
ensp
ENSP00000523384
resolver
ensp
ENSP00000523385
resolver
ensp
ENSP00000523386
resolver
ensp
ENSP00000523387
resolver
ensp
ENSP00000640008
resolver
ensp
ENSP00000640009
resolver
ensp
ENSP00000640010
resolver
ensp
ENSP00000640011
resolver
ensp
ENSP00000640012
resolver
ensp
ENSP00000640013
resolver
ensp
ENSP00000640014
resolver
ensp
ENSP00000640015
resolver
ensp
ENSP00000640016
resolver
enst
ENST00000397095
resolver
enst
ENST00000444847
resolver
enst
ENST00000853316
resolver
enst
ENST00000853317
resolver
enst
ENST00000853318
resolver
enst
ENST00000853319
resolver
enst
ENST00000853320
resolver
enst
ENST00000853321
resolver
enst
ENST00000853322
resolver
enst
ENST00000853323
resolver
enst
ENST00000853324
resolver
enst
ENST00000853325
resolver
enst
ENST00000853326
resolver
enst
ENST00000853327
resolver
enst
ENST00000853328
resolver
enst
ENST00000969949
resolver
enst
ENST00000969950
resolver
enst
ENST00000969951
resolver
enst
ENST00000969952
resolver
enst
ENST00000969953
resolver
enst
ENST00000969954
resolver
enst
ENST00000969955
resolver
enst
ENST00000969956
resolver
enst
ENST00000969957
resolver
genesymbol
GPR146
resolver
genesymbol_syn
PGR8
resolver
hgnc
HGNC:21718
resolver
uniprot
A4D2Q3
resolver
uniprot
B4DTD6
resolver
uniprot
Q86SP5
resolver
uniprot_entry
A4D2Q3_HUMAN
resolver
uniprot_entry
B4DTD6_HUMAN
resolver
uniprot_entry
GP146_HUMAN
resolver
uniprot_sec
Q86SP5
resolver
amino_acid_sequence
MWSCSWFNGTGLVEELPACQDLQLGLSLLSLLGLVVGVPVGLCYNALLVLANLHSKASMTMPDVYFVNMAVAGLVLSALAPVHLLGPPSSRWALWSVGGEVHVALQIPFNVSSLVAMYSTALLSLDHYIERALPRTYMASVYNTRHVCGFVWGGALLTSFSSLLFYICSHVSTRALECAKMQNAEAADATLVFIGYVVPALATLYALVLLSRVRREDTPLDRDTGRLEPSAHRLLVATVCTQFGLWTPHYLILLGHTVIISRGKPVDAHYLGLLHFVKDFSKLLAFSSSFVTPLLYRYMNQSFPSKLQRLMKKLPCGDRHCSPDHMGVQQVLA
uniprot
proteins
function
FUNCTION: G protein-coupled receptor required for the regulation of plasma cholesterol levels (PubMed:31778654, PubMed:38503280). Receptor for CHLSN, a gut derived hormone which mediates an inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis. Cholesin-binding exerts an antagonistic effect by inhibiting PKA signaling and suppressing SREBF2-controlled cholesterol in the liver (PubMed:38503280). {ECO:0000269|PubMed:31778654, ECO:0000269|PubMed:38503280}.
uniprot
proteins
mass_dalton
36580
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
31778654
uniprot
proteins
pubmed
38503280
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:38503280}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 66..86; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 147..167; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 234..254; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 280..300; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins