GLCE
entrez
26035
canonical
uniprot
O94923
canonical
ensembl
ENSG00000138604
resolver
ensp
ENSP00000261858
resolver
enst
ENST00000261858
resolver
genesymbol
GLCE
resolver
genesymbol_syn
KIAA0836
resolver
hgnc
HGNC:17855
resolver
uniprot
Q6GUQ2
resolver
uniprot_entry
GLCE_HUMAN
resolver
uniprot_sec
Q6GUQ2
resolver
amino_acid_sequence
MRCLAARVNYKTLIIICALFTLVTVLLWNKCSSDKAIQFPRRSSSGFRVDGFEKRAAASESNNYMNHVAKQQSEEAFPQEQQKAPPVVGGFNSNVGSKVLGLKYEEIDCLINDEHTIKGRREGNEVFLPFTWVEKYFDVYGKVVQYDGYDRFEFSHSYSKVYAQRAPYHPDGVFMSFEGYNVEVRDRVKCISGVEGVPLSTQWGPQGYFYPIQIAQYGLSHYSKNLTEKPPHIEVYETAEDRDKNKPNDWTVPKGCFMANVADKSRFTNVKQFIAPETSEGVSLQLGNTKDFIISFDLKFLTNGSVSVVLETTEKNQLFTIHYVSNAQLIAFKERDIYYGIGPRTSWSTVTRDLVTDLRKGVGLSNTKAVKPTKIMPKKVVRLIAKGKGFLDNITISTTAHMAAFFAASDWLVRNQDEKGGWPIMVTRKLGEGFKSLEPGWYSAMAQGQAISTLVRAYLLTKDHIFLNSALRATAPYKFLSEQHGVKAVFMNKHDWYEEYPTTPSSFVLNGFMYSLIGLYDLKETAGEKLGKEARSLYERGMESLKAMLPLYDTGSGTIYDLRHFMLGIAPNLARWDYHTTHINQLQLLSTIDESPVFKEFVKRWKSYLKGSRAKHN
uniprot
proteins
ec_number
5.1.3.17
uniprot
proteins
function
FUNCTION: Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. {ECO:0000269|PubMed:20118238, ECO:0000269|PubMed:22528493, ECO:0000269|PubMed:30872481}.
uniprot
proteins
mass_dalton
70101
uniprot
proteins
mutagenesis
MUTAGEN 146; /note="Y->A: Reduces enzyme activity by about 60%."; /evidence="ECO:0000269|PubMed:20118238"; MUTAGEN 162; /note="Y->A: Reduces enzyme activity by about 75%."; /evidence="ECO:0000269|PubMed:20118238"; MUTAGEN 168; /note="Y->A: Almost abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:20118238"; MUTAGEN 210; /note="Y->A: Reduces enzyme activity by about 30%."; /evidence="ECO:0000269|PubMed:20118238"; MUTAGEN 222; /note="Y->A: Almost abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:20118238"; MUTAGEN 499; /note="E->Q: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:30872481"; MUTAGEN 500; /note="Y->F: Mildly decreased enzyme activity."; /evidence="ECO:0000269|PubMed:30872481"; MUTAGEN 578; /note="Y->F: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:30872481
uniprot
proteins
pathway_participation
PATHWAY: Glycan metabolism; heparan sulfate biosynthesis. {ECO:0000305|PubMed:22528493, ECO:0000305|PubMed:30872481}.; PATHWAY: Glycan metabolism; heparin biosynthesis. {ECO:0000305}.
uniprot
proteins
protein_family
D-glucuronyl C5-epimerase family
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
20118238
uniprot
proteins
pubmed
22528493
uniprot
proteins
pubmed
30872481
uniprot
proteins
sequence_length
617
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9EPS3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9EPS3}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..28; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins