Fem1al
entrez
216622
canonical
uniprot
Q8C0T1
canonical
ensembl
ENSMUSG00000078157
resolver
ensp
ENSMUSP00000100568
resolver
enst
ENSMUST00000104962
resolver
genesymbol
Fem1al
resolver
genesymbol_syn
Fem1ab
resolver
uniprot
B2RT26
resolver
uniprot
Q5RJ26
resolver
uniprot_entry
FM1AB_MOUSE
resolver
uniprot_sec
B2RT26
resolver
uniprot_sec
Q5RJ26
resolver
amino_acid_sequence
MDLHTAVYNAAHDGKLPLLQKLLASRGREELEELLGEVAGGGTPLLIAARRGHLDVVEYLVDHCGASVEASGSVHFDGETIEGAPPLWAASAAGHLAVVRSLLHRGASVNRTTCTNSTPLRAACFNGHLDVVRCLVGEHKADLEVANRHGHTCLMISCYKGHREIARYLLERGAQVNRRSAKGNTALHDCAESGSLEILQLLLSCHARMERDGYGMTPLLAASITGHTNIVEYLIQEQPSHEQLSGTELPGEGSSQMAGNHCSTPEDAEQYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGGFLPKPEPQQLVLAYDYSREVTTPQELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQNNLEPLSPMTASSFLSFAELFSYVLQDHSAKGNLGMQLDFADLIGVLSKGVREVERALQLPKEPDDSAQFTKAIAIILHLLYLLEKVECTPRQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKETTNVGQYHVGVFPSLQVVKVLLDCGADPDSRDFDNNSPLHIAAQNNCPAIMDALIEAGAHMDATNTFKKTAYELLDSKLLAKSTVQPFNYVTLQCLAARALDRNKVPYKGFIPEELEAFIQLH
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. {ECO:0000250|UniProtKB:Q9BSK4}.
uniprot
proteins
mass_dalton
72210
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9BSK4}.
uniprot
proteins
protein_family
Fem-1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
654
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9BSK4}. Cytoplasm {ECO:0000250|UniProtKB:Q9BSK4}.
uniprot
proteins