Rabgef1
entrez
56715
canonical
uniprot
Q9JM13
canonical
ensembl
ENSMUSG00000025340
resolver
ensp
ENSMUSP00000026390
resolver
ensp
ENSMUSP00000114103
resolver
ensp
ENSMUSP00000284378
resolver
ensp
ENSMUSP00000284379
resolver
ensp
ENSMUSP00000284393
resolver
enst
ENSMUST00000026390
resolver
enst
ENSMUST00000119797
resolver
genesymbol
Rabgef1
resolver
genesymbol_syn
Rabex5
resolver
uniprot
Q3UIW0
resolver
uniprot_entry
RABX5_MOUSE
resolver
uniprot_sec
Q3UIW0
resolver
amino_acid_sequence
MSLKSERRGIHVDQSELLCKKGCGYYGNPAWQGFCSKCWREEYHKARQRQIQEDWELAERLQREEEEAFASSQSSQGAQSLTFSKFEEKKTNEKTRKVTTVKKFFSASSRAGSKKEIQEAKAPSPSINRQTSIETDRVTKEFIDFLKTFHKTGQEVYKQTKMFLEAMPYKRDLSIEEQSECTQDFYQNVAERMQTRGKVPPEKVEKIMDQIEKHIMTRLYKFVFCPETTDDEKKDLAIQKRIRALHWVTPQMLCVPVNEEIPEVSDMVVKAITDIIEMDSKRVPRDKLACITRCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGNPPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQESESWPPEACLGVKQMYKNLDLLSQLNERQERIMNEAKKLEKDLIDWTDGIAKEVQDIVEKYPLEIKPPNQPLAAIDSENVENDKLPPPLQPQVYAG
uniprot
proteins
function
FUNCTION: Acts as a guanine-nucleotide releasing factor (GEF) for RAB5A by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (By similarity). Forms a complex with RABEP1 that acts as Rab4/Rab5 effector regulating endosome fusion. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes (By similarity). Also functions as a ubiquitin ligase (By similarity). {ECO:0000250|UniProtKB:O18973, ECO:0000250|UniProtKB:Q9UJ41}.
uniprot
proteins
mass_dalton
56869
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated. {ECO:0000250}.
uniprot
proteins
pubmed
10926822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Early endosome {ECO:0000250}. Recycling endosome {ECO:0000250}.
uniprot
proteins