Cushing syndrome
cv_term_accession
KW-1062
canonical
uniprot_keyword
KW-1062
canonical
name
Cushing syndrome
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synonym
Cushing's syndrome
uniprot
synonym
Hyperadrenocorticism
uniprot
synonym
Hypercortisolism
uniprot
definition
Protein which, if defective, causes Cushing syndrome, a condition caused by prolonged exposure to excess levels of cortisol from endogenous or exogenous sources. Endogenous Cushing syndrome is due to excess production of cortisol by the adrenal glands. It may be caused by pituary hypersecretion of adrenocorticotropic hormone (ACTH), ectopic ACTH secretion by non-pituary tumors, or may result from cortisol hypersecretion by adrenal gland tumors (ACTH-independent Cushing syndrome). Cushing syndrome is clinically characterized by upper body obesity, osteoporosis, hypertension, diabetes mellitus, hirsutism, amenorrhea, and excess body fluid.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
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uniprot
keywords