Klf10
entrez
81813
canonical
uniprot
O08876
canonical
ensembl
ENSRNOG00000006118
resolver
ensembl
ENSRNOG00055023377
resolver
ensembl
ENSRNOG00060009681
resolver
ensembl
ENSRNOG00065003814
resolver
ensp
ENSRNOP00000008350
resolver
ensp
ENSRNOP00000101003
resolver
ensp
ENSRNOP00055032609
resolver
ensp
ENSRNOP00060012750
resolver
ensp
ENSRNOP00065004057
resolver
enst
ENSRNOT00000008350
resolver
enst
ENSRNOT00000128373
resolver
enst
ENSRNOT00055040167
resolver
enst
ENSRNOT00060016330
resolver
enst
ENSRNOT00065005580
resolver
genesymbol
Klf10
resolver
genesymbol_syn
Cpg20
resolver
genesymbol_syn
Tieg
resolver
genesymbol_syn
Tieg1
resolver
uniprot
A0ABK0LCN0
resolver
uniprot
Q4QRA4
resolver
uniprot_entry
A0ABK0LCN0_RAT
resolver
uniprot_entry
KLF10_RAT
resolver
uniprot_sec
Q4QRA4
resolver
amino_acid_sequence
MLNFGASLQQASEGKMELISEKSKEGAHPWDKAEQSDFEAVEALMSMSCDWKSHFKKYLENRPVTPVSDTSEEDSLLPGTPDLQTVPAFCLTPPYSPSDFEPSQGSNLTAPAPPTGHFRSLSDAAKPPSIAPFKEEEKSPLAAPPLPKAQATSVIRHTADAQLCNHQSCPVKAASILNYQDNSFRRRTHINVEATRKNIPCAAVSPNRPKPEPSTAANGAEKAGTAPYDFAVPSSETVICRSSQPAPTSPVQKSVLMSSPTVSTGGVPPLPVICQMVPLPANNSLVTTVVPSSPPSQPPAVCSPVLFMGTQVPKGTVMFVVPQPVVQSPKPPVVSPNGTRLSPIAPAPGFSPSAARVTPQIDSSRVRSHICSHPGCGKTYFKSSHLKAHVRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDRRFMRSDHLTKHARRHLSAKKLPNWQMEVSKLNDIALPPATASAQ
uniprot
proteins
function
FUNCTION: Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. {ECO:0000250|UniProtKB:O89091, ECO:0000250|UniProtKB:Q13118, ECO:0000269|PubMed:20070857}.
uniprot
proteins
mass_dalton
51829
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. {ECO:0000250|UniProtKB:Q13118}.
uniprot
proteins
protein_family
Sp1 C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20070857
uniprot
proteins
pubmed
9699150
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20070857}.
uniprot
proteins