BCAR3
entrez
8412
canonical
uniprot
O75815
canonical
ensembl
ENSG00000137936
resolver
ensp
ENSP00000260502
resolver
ensp
ENSP00000359263
resolver
ensp
ENSP00000359264
resolver
ensp
ENSP00000359267
resolver
ensp
ENSP00000441343
resolver
ensp
ENSP00000521929
resolver
ensp
ENSP00000521930
resolver
ensp
ENSP00000604192
resolver
ensp
ENSP00000604194
resolver
ensp
ENSP00000629745
resolver
ensp
ENSP00000629746
resolver
ensp
ENSP00000629749
resolver
ensp
ENSP00000683952
resolver
ensp
ENSP00000782002
resolver
genesymbol
BCAR3
resolver
genesymbol_syn
NSP2
resolver
genesymbol_syn
SH2D3B
resolver
hgnc
HGNC:973
resolver
uniprot
A0A384MTS3
resolver
uniprot
B3KNL6
resolver
uniprot
B3KP06
resolver
uniprot
D3DT43
resolver
uniprot
Q5TEW3
resolver
uniprot
Q6UW40
resolver
uniprot
Q9BR50
resolver
uniprot_entry
A0A384MTS3_HUMAN
resolver
uniprot_entry
B3KNL6_HUMAN
resolver
uniprot_entry
B3KP06_HUMAN
resolver
uniprot_entry
BCAR3_HUMAN
resolver
uniprot_sec
D3DT43
resolver
uniprot_sec
Q5TEW3
resolver
uniprot_sec
Q6UW40
resolver
uniprot_sec
Q9BR50
resolver
amino_acid_sequence
MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
uniprot
proteins
function
FUNCTION: Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}.
uniprot
proteins
mass_dalton
92566
uniprot
proteins
mutagenesis
MUTAGEN 177; /note="R->K: Abolishes localization to focal adhesions. Reduces interaction with PTPRA."; /evidence="ECO:0000269|PubMed:22801373"; MUTAGEN 744; /note="L->E: Weakens interaction with BCAR1."; /evidence="ECO:0000269|PubMed:22081014"; MUTAGEN 748; /note="R->A: Abolishes interaction with BCAR1 and SRC."; /evidence="ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:22801373
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues. {ECO:0000250|UniProtKB:Q9QZK2}.
uniprot
proteins
pubmed
10187783
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18722344
uniprot
proteins
pubmed
19086031
uniprot
proteins
pubmed
19103205
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22081014
uniprot
proteins
pubmed
22801373
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24216110
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9582273
uniprot
proteins
sequence_length
825
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QZK2}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q9QZK2}. Note=Localization to focal adhesions depends on interaction with PTPRA. {ECO:0000250|UniProtKB:Q9QZK2}.
uniprot
proteins