Asic5
entrez
63866
canonical
uniprot
Q9R0W5
canonical
ensembl
ENSRNOG00000011842
resolver
ensembl
ENSRNOG00055001310
resolver
ensembl
ENSRNOG00060007192
resolver
ensembl
ENSRNOG00065030828
resolver
ensp
ENSRNOP00000016039
resolver
ensp
ENSRNOP00055001676
resolver
ensp
ENSRNOP00060008917
resolver
ensp
ENSRNOP00065043654
resolver
enst
ENSRNOT00000016039
resolver
enst
ENSRNOT00055002156
resolver
enst
ENSRNOT00060011847
resolver
enst
ENSRNOT00065053149
resolver
genesymbol
Asic5
resolver
genesymbol_syn
Accn5
resolver
uniprot_entry
ASIC5_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the diuretic drug amiloride (PubMed:10457052, PubMed:20656685, PubMed:34549327). Inhibited by diminazene (PubMed:27679529, PubMed:34549327). Inhibited by extracellular Ca(2+) (PubMed:20656685). {ECO:0000269|PubMed:10457052, ECO:0000269|PubMed:20656685, ECO:0000269|PubMed:27679529, ECO:0000269|PubMed:34549327}.
uniprot
proteins
amino_acid_sequence
MEHTEKSKGPAEKGLLGKIRRYLSKRPLPSPTDRKKFDHDFAISTSFHGIHNIAQNQNKVRKVIWLSVVLGSVSLLVWQIYSRLVNYFMWPTTTSIEVQYVEKIEFPAVTFCNLNRFQTEAVSRFGIIFFLWDIVSKVLRLQEISGNNTGSPEALDFVASHRNFSITEFVKNNGFYLNHDTLVHCEFFGKTCDPKDFKHVFTEYGNCFTFNYGENVQSKNKVSVSGRGLKLLLDVHQEEFTDNPVPGFADAGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTIHQEYPWGECNPDIKLRNFTTYSTYGCLKECKAKHIQRLCGCLPFLLPGNGVECDLLKYYNCVSPILDHIERKGLCTMGTHNSSCPVPCEETEYPATIAYSTFPSQRATKFLAKKLNQSQEYIRENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIEYLFTSFYWVFIFFLLKILEMIQRTSPPQTV
uniprot
proteins
function
FUNCTION: Forms bile acid-gated sodium channels and may play a role in bile acid-dependent absorption and secretion by epithelial cells of the bile ducts (PubMed:10457052, PubMed:22735174, PubMed:27679529, PubMed:34549327). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:10457052, PubMed:20656685, PubMed:27679529). The gating could be indirect and the consequence of alterations of the membrane environment of the channel by bile acids (PubMed:25360526, PubMed:27679529). As a sodium channel of type II unipolar brush cells of the vestibulocerebellum, controlling the electrical activity of these cells, could play a role in motor coordination and balance (By similarity). {ECO:0000250|UniProtKB:Q9R0Y1, ECO:0000269|PubMed:10457052, ECO:0000269|PubMed:20656685, ECO:0000269|PubMed:22735174, ECO:0000269|PubMed:25360526, ECO:0000269|PubMed:27679529, ECO:0000269|PubMed:34549327}.
uniprot
proteins
mass_dalton
56464
uniprot
proteins
mutagenesis
MUTAGEN 387; /note="A->S: Loss of binding and inhibition by Ca(2+)."; /evidence="ECO:0000269|PubMed:20656685"; MUTAGEN 443; /note="A->C,S: Novel constitutive but weak cation channel activity."; /evidence="ECO:0000269|PubMed:10457052"; MUTAGEN 443; /note="A->F,T,V: Novel constitutive cation channel activity."; /evidence="ECO:0000269|PubMed:10457052"; MUTAGEN 443; /note="A->K: Novel constitutive intermediate cation channel activity."; /evidence="ECO:0000269|PubMed:10457052
uniprot
proteins
protein_family
ASIC5 subfamily
uniprot
proteins
protein_family
Amiloride-sensitive sodium channel (TC 1.A.6) family
uniprot
proteins
pubmed
10457052
uniprot
proteins
pubmed
20656685
uniprot
proteins
pubmed
22735174
uniprot
proteins
pubmed
25360526
uniprot
proteins
pubmed
27679529
uniprot
proteins
pubmed
34549327
uniprot
proteins
sequence_length
495
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:34549327}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:10457052, ECO:0000269|PubMed:22735174, ECO:0000269|PubMed:27679529}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 460..480; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins