Derl3
entrez
70377
canonical
uniprot
Q9D8K3
canonical
ensembl
ENSMUSG00000009092
resolver
ensp
ENSMUSP00000009236
resolver
ensp
ENSMUSP00000151623
resolver
ensp
ENSMUSP00000326994
resolver
enst
ENSMUST00000217811
resolver
genesymbol
Derl3
resolver
genesymbol_syn
Der3
resolver
genesymbol_syn
Izp6
resolver
uniprot
A0A1W2P7B5
resolver
uniprot
Q14C34
resolver
uniprot
Q3T9L7
resolver
uniprot
Q99KC6
resolver
uniprot
Q9D954
resolver
uniprot_entry
A0A1W2P7B5_MOUSE
resolver
uniprot_entry
DERL3_MOUSE
resolver
uniprot_entry
Q14C34_MOUSE
resolver
uniprot_sec
Q3T9L7
resolver
uniprot_sec
Q99KC6
resolver
uniprot_sec
Q9D954
resolver
amino_acid_sequence
MAGQRLAAGFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLITTFLFFGPLGFGFFFNMLFVFRYCRMLEEGSFRGRKADFVFMFLFGGVLMTLLGFLGSLFFLGQALMAMLVYVWSRRSPHVRVNFFGLLNFQAPFLPWALMGFSLLLGNSVVTDLLGILVGHIYYFLEDVFPNQPGGKRLLLTPSVLKLLLDDPQEDPDYLPLPEEQPEL
uniprot
proteins
function
FUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins. May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. {ECO:0000250|UniProtKB:Q96Q80}.
uniprot
proteins
mass_dalton
25978
uniprot
proteins
protein_family
Derlin family
uniprot
proteins
pubmed
11422294
uniprot
proteins
pubmed
15215855
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22016385
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96Q80}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96Q80}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 58..78; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 99..119; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 169..189; /note="Helical; Name=4"; /evidence="ECO:0000255
uniprot
proteins