Hacd2
entrez
70757
canonical
uniprot
Q9D3B1
canonical
ensembl
ENSMUSG00000035376
resolver
ensp
ENSMUSP00000060462
resolver
enst
ENSMUST00000061156
resolver
genesymbol
Hacd2
resolver
genesymbol_syn
Ptplb
resolver
uniprot
Q3UG38
resolver
uniprot
Q9JLK1
resolver
uniprot_entry
HACD2_MOUSE
resolver
uniprot_sec
Q3UG38
resolver
uniprot_sec
Q9JLK1
resolver
amino_acid_sequence
MAAAAATAATKGNGGGSGRVGAGDSSGARKKKGPGPVATAYLVIYNVVMTAGWLVIAVGLVRAYLAKGSYHSLYYSIERPLKFFQTGALLEILHCAIGIVPSSVVLTSFQVMSRVFLIWAVTHSVKEVQSEDSVLLFVIAWTITEIIRYSFYTFSLLNHLPYIIKWARYTLFIVLYPMGVTGELLTIYAALPFVRQAGLYSISLPNKYNFSFDYHAFLILIMISYIPLFPQLYFHMIHQRRKVLSHTEEHKKFE
uniprot
proteins
ec_number
4.2.1.134
uniprot
proteins
function
FUNCTION: Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction). This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of elongation. Therefore, it participates in the production of various VLCFAs involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000250|UniProtKB:Q6Y1H2}.
uniprot
proteins
mass_dalton
28402
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000250|UniProtKB:Q6Y1H2}.
uniprot
proteins
protein_family
Very long-chain fatty acids dehydratase HACD family
uniprot
proteins
pubmed
10644438
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6Y1H2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6Y1H2}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 80..97; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 108..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 131..146; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 218..235; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins