GSR
entrez
2936
canonical
uniprot
P00390
canonical
ensembl
ENSG00000104687
resolver
ensp
ENSP00000221130
resolver
ensp
ENSP00000438845
resolver
ensp
ENSP00000444559
resolver
ensp
ENSP00000445516
resolver
genesymbol
GSR
resolver
genesymbol
HEL-75
resolver
genesymbol_syn
GLUR
resolver
genesymbol_syn
GRD1
resolver
genesymbol_syn
HEL-S-122m
resolver
hgnc
HGNC:4623
resolver
uniprot
C8KIL8
resolver
uniprot
C8KIL9
resolver
uniprot
C8KIM0
resolver
uniprot
D3DSV3
resolver
uniprot
Q7Z5C9
resolver
uniprot
Q9NP63
resolver
uniprot
V9HW90
resolver
uniprot_entry
GSHR_HUMAN
resolver
uniprot_entry
V9HW90_HUMAN
resolver
uniprot_sec
C8KIL8
resolver
uniprot_sec
C8KIL9
resolver
uniprot_sec
C8KIM0
resolver
uniprot_sec
D3DSV3
resolver
uniprot_sec
Q7Z5C9
resolver
uniprot_sec
Q9NP63
resolver
amino_acid_sequence
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
uniprot
proteins
disease_involvement
DISEASE: Anemia, congenital, non-spherocytic hemolytic, 10 (CNSHA10) [MIM:618660]: An autosomal recessive disease characterized by hemolytic anemia and impaired activity of glutathione reductase. Patients experience hemolytic anemia in response to oxidative stress or ingestion of fava beans. {ECO:0000269|PubMed:17185460}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.8.1.7
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol. {ECO:0000269|PubMed:17185460}.
uniprot
proteins
mass_dalton
56257
uniprot
proteins
protein_family
Class-I pyridine nucleotide-disulfide oxidoreductase family
uniprot
proteins
pubmed
10708558
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16910673
uniprot
proteins
pubmed
17185460
uniprot
proteins
pubmed
18638483
uniprot
proteins
pubmed
20628807
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2185014
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2585516
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
3656429
uniprot
proteins
pubmed
7060551
uniprot
proteins
pubmed
7334521
uniprot
proteins
pubmed
8626496
uniprot
proteins
pubmed
9174360
uniprot
proteins
pubmed
923580
uniprot
proteins
pubmed
9546215
uniprot
proteins
sequence_length
522
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion.; SUBCELLULAR LOCATION: [Isoform Cytoplasmic]: Cytoplasm.
uniprot
proteins