Ptges3
entrez
362809
canonical
uniprot
P83868
canonical
ensembl
ENSRNOG00000002642
resolver
ensembl
ENSRNOG00055013521
resolver
ensembl
ENSRNOG00060023883
resolver
ensembl
ENSRNOG00065013256
resolver
ensp
ENSRNOP00000096677
resolver
ensp
ENSRNOP00055018840
resolver
ensp
ENSRNOP00060034480
resolver
ensp
ENSRNOP00065016874
resolver
enst
ENSRNOT00000104676
resolver
enst
ENSRNOT00055023203
resolver
enst
ENSRNOT00060041607
resolver
enst
ENSRNOT00065021795
resolver
genesymbol
Ptges3
resolver
genesymbol_syn
Tebp
resolver
uniprot
B2GV92
resolver
uniprot
R9PXR7
resolver
uniprot_entry
B2GV92_RAT
resolver
uniprot_entry
TEBP_RAT
resolver
uniprot_sec
R9PXR7
resolver
amino_acid_sequence
MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMDHMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE
uniprot
proteins
ec_number
5.3.99.3
uniprot
proteins
function
FUNCTION: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (By similarity). {ECO:0000250|UniProtKB:Q15185, ECO:0000269|PubMed:10922363}.
uniprot
proteins
mass_dalton
18721
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; prostaglandin biosynthesis. {ECO:0000269|PubMed:10922363}.
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by caspase-7 (CASP7) in response to apoptosis, leading to its inactivation. {ECO:0000250|UniProtKB:Q15185}.
uniprot
proteins
protein_family
P23/wos2 family
uniprot
proteins
pubmed
10922363
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3ZBF7}.
uniprot
proteins