Misp
entrez
78906
canonical
uniprot
Q9D279
canonical
ensembl
ENSMUSG00000035852
resolver
ensp
ENSMUSP00000048893
resolver
ensp
ENSMUSP00000130071
resolver
ensp
ENSMUSP00000151529
resolver
enst
ENSMUST00000046833
resolver
enst
ENSMUST00000169041
resolver
enst
ENSMUST00000219305
resolver
genesymbol
Misp
resolver
uniprot
Q3UI04
resolver
uniprot_entry
MISP_MOUSE
resolver
uniprot_sec
Q3UI04
resolver
amino_acid_sequence
MDRVTRYPIFSNPRSARVTSLVLDEDTSYTVELVGVGPEAGWSQGDLQAWSTEYQTRPDVKRTNVSSNRRVFLGQQSPRSLYLEDEDEEIKSYHLDDSSDTLCRQRRELEAERWAVIQSQAVRKGGTVATLQAASDHGDLRIARQPQSTVTEEILVDTEQIDFLAARQQFLSLEKANTNPVPCGLTARETFPRTPPGINQAPKASTGPHLANGYTTAVTSPMKEVTLEKSFHVSPARSIHIVNDPGSQTQAESPETPKETPIEREIRLAQEREAELREQRGLGRAAGHQELVQIPSRPLLSKMSLTETPPRRDRGRPSLYVQRDMVQETQREEDHRREGLQVGRASTPDWPSQDPQPGLQRSLSSDCILSPDARATDPAPEARKVNRIPLDAYQPYLGPGTPKLEFSAFGVYSKPSGVSTEDTKATVFQKATESPRHVSESSGRSLSSKQEWSKPPGKATNVGVVRLGNFHLRPLRFKVPDVPQGTETPHTWGWEVAGGPILRLQKSQSSDLLEREMESVLRREREVAEERRNAFFPEVFSPVPAEDESHEQDSRSSSRASGITGSYSVSESPLFTPVHLNSGLVWKVEAPEDSAPPGQKTRKEMWYAGINPSDSVNSEVLGATRVKRHKNLLAERWEAHIYASEDEN
uniprot
proteins
function
FUNCTION: Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytoskeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
72281
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK1 and PLK1. CDK1 is the priming kinase for PLK1 phosphorylation. Phosphorylation by PLK1 is required for proper spindle orientation at metaphase (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
MISP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
648
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Note=Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re-attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis (By similarity). {ECO:0000250}.
uniprot
proteins