Rtn4rl1
entrez
237847
canonical
uniprot
Q8K0S5
canonical
ensembl
ENSMUSG00000045287
resolver
ensp
ENSMUSP00000099572
resolver
enst
ENSMUST00000102514
resolver
genesymbol
Rtn4rl1
resolver
genesymbol_syn
Ngrl2
resolver
uniprot_entry
R4RL1_MOUSE
resolver
amino_acid_sequence
MLRKGCCVELLLLLLAGELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPEDSERIFLQNNRITFLQQGHFSPAMVTLWIYSNNITFIAPNTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGIFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGQGIFRGLVNLDRLLLHENQLQWVHHKAFHDLHRLTTLFLFNNSLTELQGDCLAPLVALEFLRLNGNAWDCGCRARSLWEWLRRFRGSSSAVPCATPELRQGQDLKLLRVEDFRNCTGPVSPHQIKSHTLTTSDRAARKEHHPSHGASRDKGHPHGHPPGSRSGYKKAGKNCTSHRNRNQISKVSSGKELTELQDYAPDYQHKFSFDIMPTARPKRKGKCARRTPIRAPSGVQQASSGTALGAPLLAWILGLAVTLR
uniprot
proteins
function
FUNCTION: Cell surface receptor that plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system (PubMed:22406547, PubMed:27339102). Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum (PubMed:27339102). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (PubMed:26335717). Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans (PubMed:22406547). Binds heparin (PubMed:22406547). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). {ECO:0000269|PubMed:22325200, ECO:0000269|PubMed:22406547, ECO:0000269|PubMed:26335717, ECO:0000269|PubMed:27339102}.
uniprot
proteins
mass_dalton
49836
uniprot
proteins
protein_family
Nogo receptor family
uniprot
proteins
pubmed
12839991
uniprot
proteins
pubmed
14664809
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22325200
uniprot
proteins
pubmed
22406547
uniprot
proteins
pubmed
26335717
uniprot
proteins
pubmed
27339102
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12839991}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q80WD0}. Membrane raft {ECO:0000250|UniProtKB:Q86UN2}. Perikaryon {ECO:0000250|UniProtKB:Q80WD0}. Cell projection {ECO:0000250|UniProtKB:Q80WD0}. Note=Localized to the surface of neurons, including axons. {ECO:0000250|UniProtKB:Q80WD0}.
uniprot
proteins
transmembrane_region
TRANSMEM 424..444; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins