CD300LF
entrez
146722
canonical
uniprot
Q8TDQ1
canonical
ensembl
ENSG00000186074
resolver
ensp
ENSP00000301573
resolver
ensp
ENSP00000327075
resolver
ensp
ENSP00000462309
resolver
ensp
ENSP00000463743
resolver
ensp
ENSP00000464257
resolver
ensp
ENSP00000464610
resolver
ensp
ENSP00000633491
resolver
ensp
ENSP00000633492
resolver
ensp
ENSP00000685342
resolver
enst
ENST00000583937
resolver
genesymbol
CD300LF
resolver
genesymbol_syn
CD300F
resolver
genesymbol_syn
CLM1
resolver
genesymbol_syn
IGSF13
resolver
genesymbol_syn
IREM1
resolver
genesymbol_syn
NKIR
resolver
hgnc
HGNC:29883
resolver
uniprot
B2RCL2
resolver
uniprot
B4DQD2
resolver
uniprot
C9JDN3
resolver
uniprot
J3KS52
resolver
uniprot
Q3Y6P0
resolver
uniprot
Q6UX24
resolver
uniprot
Q7Z6A6
resolver
uniprot
Q7Z7I4
resolver
uniprot
Q7Z7I5
resolver
uniprot
Q8N6D0
resolver
uniprot
Q8NAF5
resolver
uniprot_entry
B4DQD2_HUMAN
resolver
uniprot_entry
CLM1_HUMAN
resolver
uniprot_entry
J3KS52_HUMAN
resolver
uniprot_sec
B2RCL2
resolver
uniprot_sec
C9JDN3
resolver
uniprot_sec
Q3Y6P0
resolver
uniprot_sec
Q6UX24
resolver
uniprot_sec
Q7Z6A6
resolver
uniprot_sec
Q7Z7I4
resolver
uniprot_sec
Q7Z7I5
resolver
uniprot_sec
Q8N6D0
resolver
uniprot_sec
Q8NAF5
resolver
amino_acid_sequence
MPLLTLYLLLFWLSGYSIVTQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQEVKRDRVSIKDNQKNRTFTVTMEDLMKTDADTYWCGIEKTGNDLGVTVQVTIDPAPVTQEETSSSPTLTGHHLDNRHKLLKLSVLLPLIFTILLLLLVAASLLAWRMMKYQQKAAGMSPEQVLQPLEGDLCYADLTLQLAGTSPQKATTKLSSAQVDQVEVEYVTMASLPKEDISYASLTLGAEDQEPTYCNMGHLSSHLPGRGPEEPTEYSTISRP
uniprot
proteins
function
FUNCTION: Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity). {ECO:0000250|UniProtKB:Q6SJQ7, ECO:0000269|PubMed:15549731, ECO:0000269|PubMed:22043923, ECO:0000269|PubMed:24035150}.
uniprot
proteins
mass_dalton
32335
uniprot
proteins
mutagenesis
MUTAGEN 205; /note="Y->F: No interaction with PTPN6."; /evidence="ECO:0000269|PubMed:15549731"; MUTAGEN 249; /note="Y->F: Interaction with PTPN6."; /evidence="ECO:0000269|PubMed:15549731"; MUTAGEN 284; /note="Y->F: Interaction with PTPN6."; /evidence="ECO:0000269|PubMed:15549731
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine. {ECO:0000269|PubMed:15184070}.
uniprot
proteins
protein_family
CD300 family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15184070
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15549731
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17275839
uniprot
proteins
pubmed
22043923
uniprot
proteins
pubmed
24035150
uniprot
proteins
sequence_length
290
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 157..177; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins