Tsg101
entrez
22088
canonical
uniprot
Q61187
canonical
ensembl
ENSMUSG00000014402
resolver
ensp
ENSMUSP00000014546
resolver
ensp
ENSMUSP00000147748
resolver
ensp
ENSMUSP00000290233
resolver
ensp
ENSMUSP00000290246
resolver
enst
ENSMUST00000014546
resolver
genesymbol
Tsg101
resolver
uniprot
Q3UCW0
resolver
uniprot_entry
Q3UCW0_MOUSE
resolver
uniprot_entry
TS101_MOUSE
resolver
amino_acid_sequence
MAVSESQLKKMMSKYKYRDLTVRQTVNVIAMYKDLKPVLDSYVFNDGSSRELVNLTGTIPVRYRGNIYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHDWKHPRSELLELIQIMIVIFGEEPPVFSRPTVSASYPPYTATGPPNTSYMPGMPSGISAYPSGYPPNPSGYPGCPYPPAGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDGAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY
uniprot
proteins
function
FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity). {ECO:0000250|UniProtKB:Q99816}.
uniprot
proteins
mass_dalton
44124
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated at multiple sites by LRSAM1 and by MGRN1. Ubiquitination inactivates it, possibly by regulating its shuttling between an active membrane-bound protein and an inactive soluble form. Ubiquitination by MGRN1 requires the presence of UBE2D1. {ECO:0000250|UniProtKB:Q99816}.
uniprot
proteins
protein_family
UEV subfamily
uniprot
proteins
protein_family
Ubiquitin-conjugating enzyme family
uniprot
proteins
pubmed
10888872
uniprot
proteins
pubmed
12802020
uniprot
proteins
pubmed
12927808
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15908698
uniprot
proteins
pubmed
19703557
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8616888
uniprot
proteins
pubmed
9840940
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99816}. Early endosome membrane {ECO:0000250|UniProtKB:Q99816}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99816}; Cytoplasmic side {ECO:0000250|UniProtKB:Q99816}. Late endosome membrane {ECO:0000250|UniProtKB:Q99816}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99816}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q99816}. Midbody, Midbody ring {ECO:0000250|UniProtKB:Q99816}. Nucleus {ECO:0000250|UniProtKB:Q99816}. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis. {ECO:0000250|UniProtKB:Q99816}.
uniprot
proteins