FAM162A
entrez
26355
canonical
uniprot
Q96A26
canonical
ensembl
ENSG00000114023
resolver
ensp
ENSP00000419088
resolver
enst
ENST00000477892
resolver
genesymbol
FAM162A
resolver
genesymbol_syn
C3orf28
resolver
genesymbol_syn
E2IG5
resolver
hgnc
HGNC:17865
resolver
uniprot
Q9H2P1
resolver
uniprot
Q9NRN6
resolver
uniprot
Q9UJX8
resolver
uniprot_entry
F162A_HUMAN
resolver
uniprot_entry
Q9H2P1_HUMAN
resolver
uniprot_sec
Q9NRN6
resolver
uniprot_sec
Q9UJX8
resolver
amino_acid_sequence
MGSLSGLRLAAGSCFRLCERDVSSSLRLTRSSDLKRINGFCTKPQESPGAPSRTYNRVPLHKPTDWQKKILIWSGRFKKEDEIPETVSLEMLDAAKNKMRVKISYLMIALTVVGCIFMVIEGKKAAQRHETLTSLNLEKKARLKEEAAMKAKTE
uniprot
proteins
function
FUNCTION: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity). {ECO:0000250|UniProtKB:Q9D6U8, ECO:0000269|PubMed:15082785}.
uniprot
proteins
mass_dalton
17342
uniprot
proteins
protein_family
UPF0389 family
uniprot
proteins
pubmed
11085516
uniprot
proteins
pubmed
15082785
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16698020
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
154
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:15082785, ECO:0000269|PubMed:16698020}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 103..120; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins