Aox3
entrez
493909
canonical
uniprot
Q5QE80
canonical
ensembl
ENSRNOG00000014555
resolver
ensp
ENSRNOP00000076035
resolver
enst
ENSRNOT00000092906
resolver
genesymbol
Aox3
resolver
genesymbol_syn
Aoh1
resolver
uniprot
A0A1B0GWV6
resolver
uniprot_entry
A0A1B0GWV6_RAT
resolver
uniprot_entry
AOXC_RAT
resolver
amino_acid_sequence
MSRSKESDELIFFVNGKKVIERNADPEVNLLFYLRKIIQLTGTKYGCGGGDCGACTVMISRYNPISKKISHFSAAACLVPICSLHGAAVTTVEGIGSTKTRIHPVQERIAKGHGTQCGFCTPGMVMSIYTLLRNHPEPSTEQIMETLGGNLCRCTGYRPIVESARSFSPNSACCPMNEKWKCCLDEGKNEPERKNSVCTKLYEKEEFQPLDPTQELIFPPELMRMAEDSPNTVLTFRGERTTWIAPGTLNDLLELKMEYPSAPLVIGNTCLGLDMKFKDVSYPIIISPARILELFVVTNTNEGLTLGAGLSLTQVKNILSDVVSRLPKERTQTYRALLKHLRTLAGQQIRNVASLGGHIISRLPTSDLNPIFGVGNCKLNVASTEGTQQIPLNDHFLAGVPEAILKPEQVLISVFVPLSRKWEFVSAFRQAPRQQNAFAIVNAGMRVAFKEDTNTITDLSILYGGIGATVVSAKSCQQLIGRCWDEEMLDDAGRMIREEVSLLTAAPGGMVEYRKTLAISFLFKFYLDVLKQLKRRNPHRCPDISQKLLQVLEDFPLTMPHGTQSFKDVDSQQPLQDQSGRPIMHQSGIKHATGEAVFCDDMSVLAGELFLAVVTSSKPHARIISLDASEALASPGVVDVITAQDVPGDNGREEESLYAQDEVICVGQIVCAVAADSYARAKQATKKVKIVYEDMEPMIVTVQDALQHESFIGPEKKLEQGNVQLAFQSADQILEGEVHLGGQEHFYMETQSVRVIPKGEDMEMDIYVSSQDAAFTQEMVARTLGIPKNRITCHVKRVGGGFGGKTSKPGLLASVAAVAAQKTGRPIRFILERGDDMLITGGRHPLLGKYRVGFMNNGKIKAADIQLYINGGCTPDDSELVIEYALLKLENAYKIPNLRVRGRVCKTNLPSNTAFRGFGFPQGAFVTGTWVSAVAAKCHLPPEKVRELNMYKTIDRTIHKQEFDPTNLIKCWETCMENSSYYSRKKAVDEFNQQSFWKKRGIAIIPMKFSVGFPKTFYHQAAALVQIYTDGSVLVAHGGVELGQGINTKMIQVASRELKIPMSYIHLDEMNTMTVPNTITTGGSTGADVNGRAVQNACQILMKRLEPIISQNPNGDWEEWINEAFIQSISLSATGYFRGYQADMDWEKGEGDIYPYFVFGAACSEVEIDCLTGAHKNIRTDIVMDGSFSINPAVDIGQIEGAFVQGLGLYTLEELKYSPEGVLYTRGPHQYKIASVSDIPEEFHVSLLTPTQNPKAIYSSKGLGEAGMFLGSSVFFAIAAAVAAARKERGLPLILAINSPATAEVIRMACEDQFTNLVPKTDSKCCKPWSIPVA
uniprot
proteins
ec_number
1.17.3.-
uniprot
proteins
ec_number
1.2.3.1
uniprot
proteins
function
FUNCTION: Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and phthalazine, as well as aldehydes, such as benzaldehyde, retinal and pyridoxal. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. Is a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also catalyzes nitric oxide (NO) production; under anaerobic conditions, reduces nitrite to NO with NADH or aldehyde as electron donor, but under aerobic conditions, NADH is the preferred substrate. These reactions may be catalyzed by several isozymes. {ECO:0000269|PubMed:17353002, ECO:0000269|PubMed:19801639}.
uniprot
proteins
mass_dalton
146751
uniprot
proteins
protein_family
Xanthine dehydrogenase family
uniprot
proteins
pubmed
15383531
uniprot
proteins
pubmed
17353002
uniprot
proteins
pubmed
19801639
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23263164
uniprot
proteins
sequence_length
1334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17353002}.
uniprot
proteins