Sc5d
entrez
114100
canonical
uniprot
Q9EQS5
canonical
ensembl
ENSRNOG00000065944
resolver
ensembl
ENSRNOG00055018957
resolver
ensembl
ENSRNOG00060018782
resolver
ensembl
ENSRNOG00065023232
resolver
ensp
ENSRNOP00000092291
resolver
ensp
ENSRNOP00055026149
resolver
ensp
ENSRNOP00060026373
resolver
ensp
ENSRNOP00065032289
resolver
enst
ENSRNOT00000106582
resolver
enst
ENSRNOT00055032323
resolver
enst
ENSRNOT00060032362
resolver
enst
ENSRNOT00065039699
resolver
genesymbol
Sc5d
resolver
genesymbol_syn
C5d
resolver
uniprot_entry
SC5D_RAT
resolver
amino_acid_sequence
MDLVLSAADYYFFTPYVYPATWPEDNIIRQTVSLLVVTNLGAYILYFFCATLSYYFVYDHSLMKHPQFLKNQVSREIMFTVKSLPWISIPTVSLFLLELRGYSKLYDDIGDFPNGWIHLIMSVISFLFFTDMLIYWIHRGLHHRLLYKHIHKPHHIWKIPTPFASHAFHPVDGFLQSLPYHIYPFVFPLHKVVYLGLYVLVNVWTISIHDGDFRVPQIFRPFINGSAHHTDHHMLFDYNYGQYFTLWDRIGGSFKHPSSFEGKGPHSYVKNMTEKESNSLAENGCKSKKLCNGEFTKNE
uniprot
proteins
ec_number
1.14.19.20
uniprot
proteins
function
FUNCTION: Catalyzes the penultimate step of the biosynthesis of cholesterol, the dehydrogenation of lathosterol into 7-dehydrocholesterol (7-DHC). Cholesterol is the major sterol component in mammalian membranes and a precursor for bile acid and steroid hormone synthesis (PubMed:4019441). In addition to its essential role in cholesterol biosynthesis, it also indirectly regulates ferroptosis through the production of 7-DHC. By diverting the spread of damage caused by peroxyl radicals from the phospholipid components to its sterol nucleus, 7-DHC prevents this form of cell death (By similarity). {ECO:0000250|UniProtKB:O75845, ECO:0000269|PubMed:4019441}.
uniprot
proteins
mass_dalton
35147
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; cholesterol biosynthesis. {ECO:0000269|PubMed:4019441}.
uniprot
proteins
protein_family
Sterol desaturase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
4019441
uniprot
proteins
pubmed
9056262
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:4019441}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins