Aplnr
entrez
83518
canonical
uniprot
Q9JHG3
canonical
ensembl
ENSRNOG00000009227
resolver
ensembl
ENSRNOG00055021872
resolver
ensembl
ENSRNOG00060011535
resolver
ensembl
ENSRNOG00065024102
resolver
ensp
ENSRNOP00000012379
resolver
ensp
ENSRNOP00055030598
resolver
ensp
ENSRNOP00060015337
resolver
ensp
ENSRNOP00065033752
resolver
enst
ENSRNOT00000012379
resolver
enst
ENSRNOT00055037514
resolver
enst
ENSRNOT00060019521
resolver
enst
ENSRNOT00065041324
resolver
genesymbol
Aplnr
resolver
genesymbol_syn
Agtrl1
resolver
genesymbol_syn
Apj
resolver
uniprot
Q9ESK2
resolver
uniprot_entry
APJ_RAT
resolver
uniprot_sec
Q9ESK2
resolver
amino_acid_sequence
MEDDGYNYYGADNQSECDYADWTPSGALIPAIYILVFLLGTTGNGLVLWTVFWSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYREFDWPFGTFSCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAVPVMVFRSTDIPENSTKTQCYMDYSMVATSNSEWAWEVGLGVSSTAVGFVVPFIIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGNLLHWPCDFDSFLMNVFPYCTCISYVNSCLNPFLYAFFDPRFRRACTSMLCCDQSGCKGSPHSSSAEKSASYSSGHSQGPGPNMCKGGEPMHEKSIPYSQETLVD
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis (PubMed:11359874). When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway that promotes internalization of the receptor. APLNR/APJ also functions as mechanoreceptor that is activated by pathological stimuli in a G protein-independent fashion to induce beta-arrestin signaling, hence eliciting cardiac hypertrophy. However, the presence of apelin ligand blunts cardiac hypertrophic induction from APLNR/APJ on response to pathological stimuli (PubMed:22810587). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a APELA receptor (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (By similarity). {ECO:0000250|UniProtKB:P35414, ECO:0000250|UniProtKB:Q7SZP9, ECO:0000250|UniProtKB:Q9WV08, ECO:0000269|PubMed:11359874, ECO:0000269|PubMed:22810587}.
uniprot
proteins
mass_dalton
42349
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10777510
uniprot
proteins
pubmed
11004481
uniprot
proteins
pubmed
11146423
uniprot
proteins
pubmed
11359874
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22810587
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11359874}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P79960}. Note=After exposure to apelin (APLN), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (PubMed:11359874). After exposure to apelin receptor early endogenous ligand (APELA), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (By similarity). {ECO:0000250|UniProtKB:P35414, ECO:0000269|PubMed:11359874}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..52; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P35414"; TRANSMEM 63..84; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P35414"; TRANSMEM 98..123; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P35414"; TRANSMEM 145..162; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P35414"; TRANSMEM 197..221; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P35414"; TRANSMEM 245..268; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P35414"; TRANSMEM 288..310; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P35414
uniprot
proteins