COX7C
entrez
1350
canonical
uniprot
P15954
canonical
ensembl
ENSG00000127184
resolver
ensp
ENSP00000247655
resolver
ensp
ENSP00000425759
resolver
ensp
ENSP00000570889
resolver
ensp
ENSP00000597243
resolver
ensp
ENSP00000597244
resolver
ensp
ENSP00000597245
resolver
ensp
ENSP00000597247
resolver
enst
ENST00000247655
resolver
enst
ENST00000509578
resolver
enst
ENST00000900830
resolver
enst
ENST00000927184
resolver
enst
ENST00000927185
resolver
enst
ENST00000927186
resolver
enst
ENST00000927188
resolver
genesymbol
COX7C
resolver
hgnc
HGNC:2292
resolver
uniprot
Q6NR81
resolver
uniprot_entry
COX7C_HUMAN
resolver
uniprot_sec
Q6NR81
resolver
amino_acid_sequence
MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLVVRHQLLKT
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P04039}.
uniprot
proteins
mass_dalton
7246
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P04039}.
uniprot
proteins
protein_family
Cytochrome c oxidase VIIc family
uniprot
proteins
pubmed
10072584
uniprot
proteins
pubmed
1309697
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2155413
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28844695
uniprot
proteins
pubmed
30030519
uniprot
proteins
pubmed
31536960
uniprot
proteins
sequence_length
63
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Single-pass membrane protein {ECO:0000269|PubMed:30030519}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..60; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P00430
uniprot
proteins