ALDH1L1
entrez
10840
canonical
uniprot
O75891
canonical
ensembl
ENSG00000144908
resolver
ensp
ENSP00000273450
resolver
ensp
ENSP00000377083
resolver
ensp
ENSP00000395881
resolver
ensp
ENSP00000570840
resolver
ensp
ENSP00000631134
resolver
ensp
ENSP00000631136
resolver
genesymbol
ALDH1L1
resolver
genesymbol_syn
FTHFD
resolver
hgnc
HGNC:3978
resolver
uniprot
B4DG36
resolver
uniprot
E9PBX3
resolver
uniprot
Q53H87
resolver
uniprot
Q68CS1
resolver
uniprot
Q8TBP8
resolver
uniprot_entry
AL1L1_HUMAN
resolver
uniprot_entry
Q53H87_HUMAN
resolver
uniprot_sec
B4DG36
resolver
uniprot_sec
E9PBX3
resolver
uniprot_sec
Q68CS1
resolver
uniprot_sec
Q8TBP8
resolver
amino_acid_sequence
MKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWRAKGQALPDVVAKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASAINWTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAVRLIAEGKAPRLPQPEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEACEQKLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMILASNFFKGAASSVLELTEAELVTAEAVRSVWQRILPKVLEVEDSTDFFKSGAASVDVVRLVEEVKELCDGLELENEDVYMASTFGDFIQLLVRKLRGDDEEGECSIDYVEMAVNKRTVRMPHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTFEY
uniprot
proteins
ec_number
1.5.1.6
uniprot
proteins
function
FUNCTION: Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:19933275, PubMed:21238436). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity). {ECO:0000250|UniProtKB:P28037, ECO:0000269|PubMed:19933275, ECO:0000269|PubMed:21238436}.
uniprot
proteins
mass_dalton
98829
uniprot
proteins
mutagenesis
MUTAGEN 354; /note="S->A: Loss of phosphopantetheinylation by AASDHPPT. Loss of formyltetrahydrofolate dehydrogenase activity."; /evidence="ECO:0000269|PubMed:19933275
uniprot
proteins
post_translational_modification
PTM: Phosphopantetheinylation at Ser-354 by AASDHPPT is required for the formyltetrahydrofolate dehydrogenase activity. {ECO:0000269|PubMed:19933275}.
uniprot
proteins
protein_family
ALDH1L subfamily
uniprot
proteins
protein_family
GART family; Aldehyde dehydrogenase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17057331
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19933275
uniprot
proteins
pubmed
20498374
uniprot
proteins
pubmed
21238436
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
902
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:19933275}.
uniprot
proteins