Bsnd
entrez
192675
canonical
uniprot
Q8R2H3
canonical
ensembl
ENSRNOG00000006543
resolver
ensembl
ENSRNOG00055031790
resolver
ensembl
ENSRNOG00060020036
resolver
ensembl
ENSRNOG00065022411
resolver
ensp
ENSRNOP00000008739
resolver
ensp
ENSRNOP00055045453
resolver
ensp
ENSRNOP00060028445
resolver
ensp
ENSRNOP00065030941
resolver
enst
ENSRNOT00000008739
resolver
enst
ENSRNOT00055055008
resolver
enst
ENSRNOT00060034643
resolver
enst
ENSRNOT00065038219
resolver
genesymbol
Bsnd
resolver
uniprot_entry
BSND_RAT
resolver
amino_acid_sequence
MADEKTFRIGFIVLGLFLLSLGTFLMSHDRPQVYGTFYAMGSIMVIGGVLWSMCQCYPKITFVPADSDFQGMLSPKALSLLETGLSEVKSPQPPYVRLWEEAAYDQSLPDFTHIQMKVMGYSEDPRPLLAPELKTGTSSAKEGEPHSAQTWMEAAVVVHRELDEKEGEKSRSQSSPPACSQGSAPLASFHDDLDVGSSEGRSPQPSPPDRDEAHLQVPWASRGPLDRFGDFALIDDTPISEDMGLEGQAQEEALPSKQPWSLRMKEETVQAGAEEPEQEEEDLYYGLPDSPGDPLPDKELGFEPDVQG
uniprot
proteins
function
FUNCTION: Regulatory subunit of anion-selective CLCNKA:BSND and CLCNKB:BSND heteromeric channels involved in basolateral chloride conductance along the nephron to achieve urine concentration and maintain systemic acid-base homeostasis, and in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (By similarity). Most likely acts as a chaperone that allosterically regulates proper sorting of CLCNKA:BSND and CLCNKB:BSND channels at the basolateral plasma membrane domain and functional switch to ion conducting state. Mediates constitutive opening of channel common gates (By similarity). {ECO:0000250|UniProtKB:Q8WZ55}.
uniprot
proteins
mass_dalton
33895
uniprot
proteins
post_translational_modification
PTM: Palmitoylation is necessary for activation of plasma membrane-inserted CLC-K/barttin channels. {ECO:0000250|UniProtKB:Q8WZ55}.
uniprot
proteins
pubmed
12111250
uniprot
proteins
pubmed
12759757
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:Q8WZ55}; Multi-pass membrane protein {ECO:0000255}. Note=Mostly sorted at the basolateral membrane. A significant amount also observed intracellularly. Staining in membranes of the renal tubule and of potassium-secreting epithelia of the inner ear is basolateral (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 33..53; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins