Cyp7a1
entrez
13122
canonical
uniprot
Q64505
canonical
ensembl
ENSMUSG00000028240
resolver
ensp
ENSMUSP00000029905
resolver
enst
ENSMUST00000029905
resolver
genesymbol
Cyp7a1
resolver
genesymbol_syn
Cyp7
resolver
uniprot
Q8BFR7
resolver
uniprot_entry
CP7A1_MOUSE
resolver
uniprot_sec
Q8BFR7
resolver
amino_acid_sequence
MMSISLIWGIAVVVSCCIWFIIGIRRRKVGEPPLDNGLIPYLGCALKFGSNPLEFLRAKQRKHGHVFTCKLMGKYVHFITNSLSYHKVLCHGKYFDWKKFHYTTSAKAFGHRSIDPSDGNTTENINKTFNKTLQGDALCSLSEAMMQNLQSVMRPPGLPKSKSAVWVTEGMYAFCYRVMFEAGYLTLFGKDISKTDSQRAFIQNNLDSFKQFDQVFPALVAGVPIHLFKTAHKARERLAESLKHKNLYMRDQVSELIRLRMFLNDTLSTFDDMEKAKTHLVILWASQANTIPATFWSLFQMIRSPEAMKAASEEVNGALQSAGQELSSGGNAIYLDQEQLNNLPVLDSIIKEALRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDESGKAKTTFYRNGNKLKYFYMPFGSGATICPGRLFAVQEIKQFLILMLSYFELELVESHTKCPPLDQSRAGLGILPPLNDIEFKYKLKH
uniprot
proteins
ec_number
1.14.14.23
uniprot
proteins
ec_number
1.14.14.26
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis (Probable). 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol. Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives (By similarity). {ECO:0000250|UniProtKB:P22680, ECO:0000305|PubMed:14522988}.
uniprot
proteins
mass_dalton
57262
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; bile acid biosynthesis. {ECO:0000269|PubMed:14522988}.; PATHWAY: Steroid metabolism; cholesterol degradation. {ECO:0000250|UniProtKB:P22680}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
14522988
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17636037
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8088795
uniprot
proteins
sequence_length
503
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P22680}; Single-pass membrane protein {ECO:0000250|UniProtKB:P22680}. Microsome membrane {ECO:0000250|UniProtKB:P22680}; Single-pass membrane protein {ECO:0000250|UniProtKB:P22680}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins