NUP98
entrez
4928
canonical
uniprot
P52948
canonical
ensembl
ENSG00000110713
resolver
ensp
ENSP00000316032
resolver
ensp
ENSP00000347404
resolver
ensp
ENSP00000352091
resolver
ensp
ENSP00000380199
resolver
ensp
ENSP00000380202
resolver
ensp
ENSP00000432142
resolver
ensp
ENSP00000436226
resolver
ensp
ENSP00000515088
resolver
ensp
ENSP00000515092
resolver
ensp
ENSP00000585361
resolver
enst
ENST00000527104
resolver
enst
ENST00000529379
resolver
enst
ENST00000700598
resolver
enst
ENST00000700603
resolver
genesymbol
NUP98
resolver
genesymbol_syn
ADAR2
resolver
hgnc
HGNC:8068
resolver
uniprot
A0A8V8TR21
resolver
uniprot
H0YCR0
resolver
uniprot
H0YEN4
resolver
uniprot
Q8IUT2
resolver
uniprot
Q8WYB0
resolver
uniprot
Q96E54
resolver
uniprot
Q9H3Q4
resolver
uniprot
Q9NT02
resolver
uniprot
Q9UF57
resolver
uniprot
Q9UHX0
resolver
uniprot
Q9Y6J4
resolver
uniprot
Q9Y6J5
resolver
uniprot_entry
A0A8V8TR21_HUMAN
resolver
uniprot_entry
H0YCR0_HUMAN
resolver
uniprot_entry
H0YEN4_HUMAN
resolver
uniprot_entry
NUP98_HUMAN
resolver
uniprot_sec
Q8IUT2
resolver
uniprot_sec
Q8WYB0
resolver
uniprot_sec
Q96E54
resolver
uniprot_sec
Q9H3Q4
resolver
uniprot_sec
Q9NT02
resolver
uniprot_sec
Q9UF57
resolver
uniprot_sec
Q9UHX0
resolver
uniprot_sec
Q9Y6J4
resolver
uniprot_sec
Q9Y6J5
resolver
amino_acid_sequence
MFNKSFGTPFGGGTGGFGTTSTFGQNTGFGTTSGGAFGTSAFGSSNNTGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGFGTSTGTANTLFGTASTGTSLFSSQNNAFAQNKPTGFGNFGTSTSSGGLFGTTNTTSNPFGSTSGSLFGPSSFTAAPTGTTIKFNPPTGTDTMVKAGVSTNISTKHQCITAMKEYESKSLEELRLEDYQANRKGPQNQVGAGTTTGLFGSSPATSSATGLFSSSTTNSGFAYGQNKTAFGTSTTGFGTNPGGLFGQQNQQTTSLFSKPFGQATTTQNTGFSFGNTSTIGQPSTNTMGLFGVTQASQPGGLFGTATNTSTGTAFGTGTGLFGQTNTGFGAVGSTLFGNNKLTTFGSSTTSAPSFGTTSGGLFGNKPTLTLGTNTNTSNFGFGTNTSGNSIFGSKPAPGTLGTGLGAGFGTALGAGQASLFGNNQPKIGGPLGTGAFGAPGFNTTTATLGFGAPQAPVALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSDPKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVSASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLANSGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVFSYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWKRSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDRHYDLNQLLEPRSITADPLDYRLSWHLWEVLRALNYTHLSAQCEGVLQASYAGQLESEGLWEWAIFVLLHIDNSGIREKAVRELLTRHCQLLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLDYIRVIEMLRHIQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSAKDRLAQSDMAKRVANLLRVVLSLHHPPDRTSDSTPDPQRVPLRLLAPHIGRLPMPEDYAMDELRSLTQSYLRELAVGSL
uniprot
proteins
disease_involvement
DISEASE: Note=Chromosomal aberrations involving NUP98 have been found in acute myeloid leukemia. Translocation t(7;11)(p15;p15) with HOXA9 (PubMed:8563753). The chimera includes NUP98 intrinsic disordered regions which contribute to aberrant liquid-liquid phase separation puncta of the chimera in the nucleus. This phase-separation enhances the chimera genomic targeting and induces organization of aberrant three-dimensional chromatin structures leading to tumorous transformation (PubMed:34163069). Translocation t(11;17)(p15;p13) with PHF23 (PubMed:17287853). {ECO:0000269|PubMed:17287853, ECO:0000269|PubMed:34163069, ECO:0000269|PubMed:8563753}.; DISEASE: Note=A chromosomal aberration involving NUP98 has been found in M0 type acute myeloid leukemia. Translocation t(4;11)(q23;p15) with RAP1GDS1. {ECO:0000269|PubMed:16419055}.; DISEASE: Note=A chromosomal aberration involving NUP98 has been found in T-cell acute lymphocytic leukemia. Translocation t(4;11)(q23;p15) with RAP1GDS1. {ECO:0000269|PubMed:10477737, ECO:0000269|PubMed:10929031}.; DISEASE: Note=A chromosomal aberration involving NUP98 has been found in M5 type acute myeloid leukemia. Translocation t(11;12)(p15;p13) with KDM5A. {ECO:0000269|PubMed:23531517}.; DISEASE: Note=Chromosomal aberrations involving NUP98 have been found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NSD1. Translocation t(8;11)(p11.2;p15) with WHSC1L1. {ECO:0000269|PubMed:16028218}.; DISEASE: Note=Chromosomal aberrations involving NUP98 have been found in M7 type childhood acute myeloid leukemia. Translocation t(11;12)(p15;p13) with KDM5A. {ECO:0000269|PubMed:16419055, ECO:0000269|PubMed:23531517}.; DISEASE: Note=A chromosomal aberration involving NUP98 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with TOP1. {ECO:0000269|PubMed:16028218}.; DISEASE: Note=A chromosomal aberration involving NUP98 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with LNP1. {ECO:0000269|PubMed:16028218}.; DISEASE: Note=A chromosomal aberration involving NUP98 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with PSIP1/LEDGF. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4. {ECO:0000269|PubMed:16028218}.; DISEASE: Note=A chromosomal aberration involving NUP98 has been identified in acute leukemias. Translocation t(6;11)(q24.1;p15.5) with CCDC28A. The chimeric transcript is an in-frame fusion of NUP98 exon 13 to CCDC28A exon 2. Ectopic expression of NUP98-CCDC28A in mouse promotes the proliferative capacity and self-renewal potential of hematopoietic progenitors and rapidly induced fatal myeloproliferative neoplasms and defects in the differentiation of the erythro-megakaryocytic lineage. {ECO:0000269|PubMed:16028218}.
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}.
uniprot
proteins
mass_dalton
197579
uniprot
proteins
mutagenesis
MUTAGEN 808; /note="K->A: No effect on autoprocessing. Severe loss of autoprocessing; when associated with A-879."; /evidence="ECO:0000269|PubMed:12191480"; MUTAGEN 816; /note="N->A: Slight reduction in autoprocessing."; /evidence="ECO:0000269|PubMed:12191480"; MUTAGEN 879; /note="H->A,Q: Moderate reduction in autoprocessing."; /evidence="ECO:0000269|PubMed:12191480"; MUTAGEN 880..883; /note="FSKY->SSKR: Loss of processing. Loss of nuclear membrane localization."; /evidence="ECO:0000269|PubMed:10087256"; MUTAGEN 881; /note="S->A: Loss of autoprocessing. Loss of nuclear membrane localization."; /evidence="ECO:0000269|PubMed:12191480, ECO:0000269|PubMed:18287282"; MUTAGEN 882; /note="K->A: No effect in autoprocessing."; /evidence="ECO:0000269|PubMed:12191480
uniprot
proteins
post_translational_modification
PTM: Isoform 1 to isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively (PubMed:10087256, PubMed:12191480, PubMed:18287282, PubMed:20407419). Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96 (PubMed:12191480, PubMed:20407419). {ECO:0000269|PubMed:10087256, ECO:0000269|PubMed:12191480, ECO:0000269|PubMed:18287282, ECO:0000269|PubMed:20407419}.; PTM: Proteolytically degraded after poliovirus (PV) infection; degradation is partial and NCP- and TPR-binding domains withstand degradation.
uniprot
proteins
protein_family
Nucleoporin GLFG family
uniprot
proteins
pubmed
10087256
uniprot
proteins
pubmed
10209021
uniprot
proteins
pubmed
10477737
uniprot
proteins
pubmed
10556215
uniprot
proteins
pubmed
10929031
uniprot
proteins
pubmed
11106761
uniprot
proteins
pubmed
11493482
uniprot
proteins
pubmed
11684705
uniprot
proteins
pubmed
11839768
uniprot
proteins
pubmed
11986249
uniprot
proteins
pubmed
12191480
uniprot
proteins
pubmed
12802065
uniprot
proteins
pubmed
15229283
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15725483
uniprot
proteins
pubmed
16028218
uniprot
proteins
pubmed
16419055
uniprot
proteins
pubmed
16467868
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17287853
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18287282
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20407419
uniprot
proteins
pubmed
20498086
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22058212
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23523133
uniprot
proteins
pubmed
23531517
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28221134
uniprot
proteins
pubmed
30543681
uniprot
proteins
pubmed
33097660
uniprot
proteins
pubmed
33360543
uniprot
proteins
pubmed
33849972
uniprot
proteins
pubmed
34163069
uniprot
proteins
pubmed
8563753
uniprot
proteins
pubmed
8563754
uniprot
proteins
sequence_length
1817
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:10087256, ECO:0000269|PubMed:11106761, ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:12191480, ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:33360543}; Peripheral membrane protein; Nucleoplasmic side {ECO:0000269|PubMed:11839768}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}. Nucleus, nucleoplasm {ECO:0000269|PubMed:12191480, ECO:0000269|PubMed:28221134}. Note=Localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket (PubMed:11839768). Dissociates from the disassembled NPC structure early during prophase of mitosis (PubMed:12802065). Colocalized with NUP153 and TPR to the nuclear basket of NPC (PubMed:11839768). Colocalized with DHX9 in diffuse and discrete intranuclear foci (GLFG-body) (PubMed:11839768, PubMed:28221134). {ECO:0000269|PubMed:11106761, ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:28221134}.; SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:11106761}. Note=(Microbial infection) Remains localized to the nuclear membrane after poliovirus (PV) infection. {ECO:0000269|PubMed:11106761}.
uniprot
proteins