MYLK2
entrez
85366
canonical
uniprot
Q9H1R3
canonical
ensembl
ENSG00000101306
resolver
ensp
ENSP00000365152
resolver
ensp
ENSP00000365162
resolver
enst
ENST00000375985
resolver
enst
ENST00000375994
resolver
genesymbol
MYLK2
resolver
hgnc
HGNC:16243
resolver
uniprot
Q569L1
resolver
uniprot
Q96I84
resolver
uniprot_entry
MYLK2_HUMAN
resolver
uniprot_sec
Q569L1
resolver
uniprot_sec
Q96I84
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+) via calmodulin. Binding of four Ca(2+) ions enables formation of a Ca(2+)-calmodulin-kinase complex that stimulates catalytic activity. Mg(2+) competitively inhibits activation by opposing Ca(2+) binding. {ECO:0000250|UniProtKB:P07313}.
uniprot
proteins
amino_acid_sequence
MATENGAVELGIQNPSTDKAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDAKAPASEKGDGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGSQDPGKPRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGVPMTHSPTDPRPAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKSEVGQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV
uniprot
proteins
disease_involvement
DISEASE: Cardiomyopathy, familial hypertrophic (CMH) [MIM:192600]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO:0000269|PubMed:11733062}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.18
uniprot
proteins
function
FUNCTION: Ca(2+)/calmodulin-dependent kinase that phosphorylates the regulatory light chain (RLC) of sarcomeric myosin in skeletal and cardiac muscle. Phosphorylation of RLC promotes displacement of myosin cross-bridges from the thick filament backbone toward actin-containing thin filaments, increasing the probability of cross-bridge entry into force-generating states and thereby potentiating contractile force at submaximal Ca(2+) concentrations. {ECO:0000250|UniProtKB:Q8VCR8, ECO:0000269|PubMed:11733062}.
uniprot
proteins
mass_dalton
64685
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11733062
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17344846
uniprot
proteins
sequence_length
596
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
uniprot
proteins