Plcb3
entrez
18797
canonical
uniprot
P51432
canonical
ensembl
ENSMUSG00000024960
resolver
ensp
ENSMUSP00000025912
resolver
ensp
ENSMUSP00000278890
resolver
enst
ENSMUST00000025912
resolver
genesymbol
Plcb3
resolver
uniprot
Q3UIS0
resolver
uniprot
Q8CI86
resolver
uniprot_entry
PLCB3_MOUSE
resolver
uniprot_entry
Q8CI86_MOUSE
resolver
uniprot_sec
Q3UIS0
resolver
activity_regulation
ACTIVITY REGULATION: Activated by G(q)/G(11) G alpha proteins in response to ligand-binding to G protein-coupled receptors. {ECO:0000250|UniProtKB:Q01970}.
uniprot
proteins
amino_acid_sequence
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDTRLEEKLMTVVAGPDPVNTTFLNFMAVQDDTVKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLNFNRSESIRPDEFPLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRSSQARLLIEKYETNKQFLERDQMSMEGFSRYLGGEENGILPLEALDLSMDMTQPLSAYFINSSHNTYLTAGQLAGPSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAEAAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIDPLDKYPLSAGIPLPSPQDLMGRILVKNKKRHRPSTGVPDSSVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKTSLEPQKSLGEESLSREPNVPMPDRDREDEEEDEEEEETTDPKKPTTDEGTASSEVNATEEMSTLVNYVEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDLPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDKKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASTETYQETPCQQPGSQLPSNPTPNPLDASPRWPPGPTTSSTSSSLSSPGQRDDLIASILSEVTPTPLEELRSHKAMVKLRSRQDRDLRELHKKHQRKAVALTRRLLDGLAQARAEGKCRPSPSALGKATNSEDVKEEEEAKQYREFQNRQVQSLLELREAQADVETKRKLEHLRQAHQRLKEVVLDTHTTQFKRLKELNEREKKELQKILDRKRNNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLEEAQKQRHERLVAGQQQVLQQLEEEEPKLLAQLTQECQEQRERLPQEIRRCLLGETAEGLGDGPLVACASNGHAPGSGGHLSSADSESQEENTQL
uniprot
proteins
ec_number
3.1.4.11
uniprot
proteins
function
FUNCTION: Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (By similarity). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:22728827). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (PubMed:22728827). In conjunction with OSBPL2, it may contribute to the control of keratinocyte proliferation and differentiation, probably through the regulation of the ERK pathway and the cell cycle (By similarity). {ECO:0000250|UniProtKB:Q01970, ECO:0000269|PubMed:22728827}.
uniprot
proteins
mass_dalton
139487
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22728827
uniprot
proteins
pubmed
9714794
uniprot
proteins
sequence_length
1234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q01970}. Membrane {ECO:0000250|UniProtKB:Q01970}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q01970}; Cytoplasmic side {ECO:0000250|UniProtKB:Q01970}. Nucleus {ECO:0000269|PubMed:9714794}. Note=An heterotetramer composed of GNG2 and GNB1 increases the concentration of PLCB3 on the membrane surface, where its substrate PIP2 resides, by orienting its catalytic site. {ECO:0000250|UniProtKB:Q01970}.
uniprot
proteins