Mr1
entrez
15064
canonical
uniprot
Q8HWB0
canonical
ensembl
ENSMUSG00000026471
resolver
ensp
ENSMUSP00000027744
resolver
genesymbol
Mr1
resolver
genesymbol_syn
Mr1a
resolver
uniprot
O19478
resolver
uniprot_entry
HMR1_MOUSE
resolver
uniprot_sec
O19478
resolver
amino_acid_sequence
MMLLLPLLAVFLVKRSHTRTHSLRYFRLAVSDPGPVVPEFISVGYVDSHPITTYDSVTRQKEPKAPWMAENLAPDHWERYTQLLRGWQQTFKAELRHLQRHYNHSGLHTYQRMIGCELLEDGSTTGFLQYAYDGQDFIIFNKDTLSWLAMDYVAHITKQAWEANLHELQYQKNWLEEECIAWLKRFLEYGRDTLERTEHPVVRTTRKETFPGITTFFCRAHGFYPPEISMTWMKNGEEIAQEVDYGGVLPSGDGTYQTWLSVNLDPQSNDVYSCHVEHCGRQMVLEAPRESGDILRVSTISGTTILIIALAGVGVLIWRRSQELKEVMYQPTQVNEGSSPS
uniprot
proteins
function
FUNCTION: Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells. In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (PubMed:15802267, PubMed:20581831, PubMed:24101382, PubMed:38537698). Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively. May present microbial antigens to various TRAV1-negative MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin. Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (By similarity). During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (PubMed:12634786, PubMed:31113973). Acts as an immune sensor of cancer cell metabolome. May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR on a non-MAIT CD8-positive T cell clone, triggering T cell-mediated killing of a wide range of cancer cell types (By similarity). May present tumor-enriched pyridoxal and pyridoxal 5'-phosphate antigens, enabling preferential recognition of cancer cells (By similarity). Presents nucleobase carbonyl adducts generated during oxidative stress. Captures M3Ade, a nucleobase adduct composed of one adenine modified by a malondialdehyde trimer, for recognition by MR1-restricted T cell clones expressing a polyclonal TCR repertoire (By similarity). {ECO:0000250|UniProtKB:Q95460, ECO:0000269|PubMed:12634786, ECO:0000269|PubMed:15802267, ECO:0000269|PubMed:20581831, ECO:0000269|PubMed:31113973, ECO:0000269|PubMed:38537698}.
uniprot
proteins
mass_dalton
39391
uniprot
proteins
mutagenesis
MUTAGEN 25; /note="Y->L: Loss of MAIT cell activation."; /evidence="ECO:0000269|PubMed:15802267"; MUTAGEN 27; /note="R->V: Loss of MAIT cell activation."; /evidence="ECO:0000269|PubMed:15802267"; MUTAGEN 40; /note="F->Y: Impair expression of folded protein."; /evidence="ECO:0000269|PubMed:15802267"; MUTAGEN 83; /note="L->K: Loss of MAIT cell activation."; /evidence="ECO:0000269|PubMed:15802267"; MUTAGEN 86; /note="G->R: Loss of MAIT cell activation."; /evidence="ECO:0000269|PubMed:15802267"; MUTAGEN 92; /note="K->R: Reduced MAIT cell activation."; /evidence="ECO:0000269|PubMed:15802267"; MUTAGEN 93; /note="A->V: Activated."; /evidence="ECO:0000269|PubMed:15802267"; MUTAGEN 99; /note="Q->R: Activated."; /evidence="ECO:0000269|PubMed:15802267"; MUTAGEN 110; /note="Y->I: Impair expression of folded protein."; /evidence="ECO:0000269|PubMed:15802267"; MUTAGEN 112; /note="R->E: Loss of MAIT cell activation."; /evidence="ECO:0000269|PubMed:15802267"; MUTAGEN 128; /note="L->Q: Impair expression of folded protein."; /evidence="ECO:0000269|PubMed:15802267"; MUTAGEN 170; /note="Y->R: Loss of MAIT cell activation."; /evidence="ECO:0000269|PubMed:15802267"; MUTAGEN 181; /note="A->E: Reduced MAIT cell activation."; /evidence="ECO:0000269|PubMed:15802267"; MUTAGEN 279; /note="C->G: No effect on cell surface expression."; /evidence="ECO:0000269|PubMed:12794138
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q95460}.
uniprot
proteins
protein_family
MHC class I family
uniprot
proteins
pubmed
11785959
uniprot
proteins
pubmed
12634786
uniprot
proteins
pubmed
12794138
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15802267
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20581831
uniprot
proteins
pubmed
24101382
uniprot
proteins
pubmed
31113973
uniprot
proteins
pubmed
38537698
uniprot
proteins
pubmed
9325151
uniprot
proteins
pubmed
9780177
uniprot
proteins
sequence_length
341
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12794138}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q95460}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q95460}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q95460}; Single-pass type I membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q95460}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q95460}; Single-pass type I membrane protein {ECO:0000255}. Note=In the absence of antigen remains within the endoplasmic reticulum where it acts as a metabolite sensor. Antigen binding triggers trafficking of the ternary complex to the plasma membrane. After presentation, most of these complexes are rapidly internalized and degraded via endocytosis. A small subset recycles via endosomes back to the plasma membrane and may thus acquire and present new antigens that do not efficiently reach the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q95460}.
uniprot
proteins
transmembrane_region
TRANSMEM 297..317; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins