Pkp2
entrez
287925
canonical
uniprot
F1M7L9
canonical
ensembl
ENSRNOG00000001825
resolver
ensp
ENSRNOP00000088522
resolver
genesymbol
Pkp2
resolver
uniprot
A0A8I6A597
resolver
uniprot_entry
PKP2_RAT
resolver
uniprot_sec
A0A8I6A597
resolver
amino_acid_sequence
MAIPGSLGECGYIRTVLGQQILGHLDSSSLALPSEARLRLAGSSGRGDPVARSQRIQEQVQQTLARRGRSSVVGGNLHRTSSVPEYVYKLHLVENDFVGRQSPAARDYDMLKVGLSGWRDGSTLKVPCTSIKPHREKKTWIEALREGLEHTTDHTDCPAHYVYSHYYFNSKKSNILVFQHIKDKSLQRNAIILLSPEHCTCQHVRLIPSSVLPSLFNQLQLSPELYFSNMGTLYMTSIKGTLCIQLLKGKLPAKHQANFVTMAERRVYTLLLSSTTSSETSFRRTGDTLPSVTSGQSRVHGLHFHHVICDCLSRNADLEMTLERAVNMLDADHVPLSKISAAATFIQHESFQKSEARKRVNQLQGIPKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNKVTVVLGKVNITKREGGGQAAGYMKETWKLANKNPVFLGLLWNLSSSDKLKHLMITEALLTLTESVIIPFSGWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGPDGRKVMRRCDGLIDSLVHYVRGTIADYQPDDKATENCVCILHNLSYQLEAELPEKYSQSIYMQNRNIQTNSNKSIGCFGSRSRKVKEQYQDTPMPEERSSPRGIEWLWHSIVIRMYLSLIAKSSRNYTQEASLGALQNLTAGSGPIPTSVARMVVQKENGLQHTRKMLHVGDPSVKKTAVSLLRNLSRNLSLQNEIAKETLPDLVSIIPDTVPSTDLLIETTASACYTLNNLMQNSYQNARDLLNTGGLQKIMTISIGEGYAPNKASKAASVLLYSLWAHTELHNAYKKAQFKKTDFVNSRTAKASHSLKD
uniprot
proteins
function
FUNCTION: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:21617128). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (By similarity). Required to maintain gingival epithelial barrier function (By similarity). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (By similarity). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (PubMed:21617128). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (PubMed:26858265). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (PubMed:19661460, PubMed:21617128). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (By similarity). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (By similarity). Binds single-stranded DNA (ssDNA) (By similarity). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (By similarity). {ECO:0000250|UniProtKB:Q99959, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:19661460, ECO:0000269|PubMed:21617128, ECO:0000269|PubMed:26858265}.
uniprot
proteins
mass_dalton
90740
uniprot
proteins
protein_family
Beta-catenin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
19661460
uniprot
proteins
pubmed
21617128
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
26858265
uniprot
proteins
sequence_length
814
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q99959}. Cell junction, desmosome {ECO:0000269|PubMed:21617128}. Cell junction {ECO:0000269|PubMed:19661460, ECO:0000269|PubMed:26858265}. Cytoplasm {ECO:0000250|UniProtKB:Q99959}. Note=Colocalizes with CTNNA3 and SCN5A/Nav1.5 at intercalated disks in the heart. {ECO:0000269|PubMed:19661460}.
uniprot
proteins