Epb41l4b
entrez
54357
canonical
uniprot
Q9JMC8
canonical
ensembl
ENSMUSG00000028434
resolver
ensp
ENSMUSP00000030142
resolver
ensp
ENSMUSP00000092687
resolver
ensp
ENSMUSP00000203559
resolver
ensp
ENSMUSP00000203560
resolver
ensp
ENSMUSP00000203561
resolver
enst
ENSMUST00000030142
resolver
enst
ENSMUST00000095076
resolver
genesymbol
Epb41l4b
resolver
genesymbol_syn
Ehm2
resolver
genesymbol_syn
Epb4.1l4b
resolver
genesymbol_syn
Lulu2
resolver
uniprot
A2ALK6
resolver
uniprot
A2ALK7
resolver
uniprot
Q3TMR3
resolver
uniprot_entry
A2ALK6_MOUSE
resolver
uniprot_entry
E41LB_MOUSE
resolver
uniprot_entry
Q3TMR3_MOUSE
resolver
uniprot_sec
A2ALK7
resolver
amino_acid_sequence
MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSVLPAAPGGSVFPAGGGPLLTGGAAVHISASGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVTHWLDHAKPIKKQMKVGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKEYRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPSNSKSARSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKASNPVIAAQLCSKANPEVHNYQPQYHPDVHPSQPRWRPHSPNVSNHSICKQNKPCFQDDRPHWKTSASGDGSHFDYVQDQNQRNLGGAYSVTYRDKLMTAL
uniprot
proteins
function
FUNCTION: Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (PubMed:22006950). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (By similarity). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (By similarity). {ECO:0000250|UniProtKB:Q9H329, ECO:0000269|PubMed:22006950}.
uniprot
proteins
mass_dalton
59564
uniprot
proteins
mutagenesis
MUTAGEN 385; /note="S->A: Abolishes in vitro phosphorylation."; /evidence="ECO:0000269|PubMed:22006950"; MUTAGEN 414; /note="S->A: Abolishes in vitro phosphorylation."; /evidence="ECO:0000269|PubMed:22006950"; MUTAGEN 419; /note="S->A: Abolishes in vitro phosphorylation."; /evidence="ECO:0000269|PubMed:22006950"; MUTAGEN 424; /note="T->A: Abolishes in vitro phosphorylation."; /evidence="ECO:0000269|PubMed:22006950
uniprot
proteins
post_translational_modification
PTM: May be negatively regulated by phosphorylation. {ECO:0000269|PubMed:22006950}.
uniprot
proteins
pubmed
10783258
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22006950
uniprot
proteins
sequence_length
527
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H329}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9H329}. Note=Accumulates along apical cell-cell boundaries and is also detected in the cytoplasm in a punctate manner. {ECO:0000250|UniProtKB:Q9H329}.
uniprot
proteins