Slc24a1
entrez
214111
canonical
uniprot
Q91WD8
canonical
ensembl
ENSMUSG00000034452
resolver
ensp
ENSMUSP00000035616
resolver
enst
ENSMUST00000037798
resolver
genesymbol
Slc24a1
resolver
genesymbol_syn
Nckx1
resolver
uniprot_entry
NCKX1_MOUSE
resolver
amino_acid_sequence
MGKLIRMGTQERRLLRPKRLHWSRLLFLLGMLIIGSTYQHLRRPQNPPSMWTKVSSQQPIKLAVRDLPNNEMAVAGSDPPEASSEVEDGMLAAQDTVIMDEAAPSIAMEDTPNPPRTTKIPPASLKNSYSPTTAGTRRQKENIPPTPSGAPSHFISTPGRQRVKSYIPKPRGERKNSSPTHAREKGRTHTPSPAGAHTISPTATVRDRETMATYRLLETRFERTAGETTAASLKRMVLNTPTFLTHEVETNLMTSSSLVGKNTAVSLRKGERNISTTPQGAVPQHTPATSEEQMTVSTRMGSIPATIEGSTAARRINNPLSRTSAPAIRIASATNREKRPSTAPSTLVTPKATMSTQVHRCVVVEPAPAVPMTPSPGVTSILFPETPSSGPSALPPGWPNLHPKAEYPPDLFSVEDRRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITHKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLSMLIVFFLDSFIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVMALGDLSKPSEDAVEENEQQDSKKLKLPSVLTRGSSSASLHNSIIRNTIYHLMLHSLDPLGEARPSKDKQESLNQEARVLSQTKAESSPDEDEPAELPAVTVTPAPAPDAKGDQEDDPGCQEDVDEAERRGEMTGEEGEKETETEGKKDEQEGETEAERKEDEQEEETEAEGKEQEGETEAEGKEDEQEGETEAEGKKDEQEGETEAEGKEEQEGETEAEGKEDEQEGETEAEGKEEQEGETEAESKEVEQERETEAEGKDKHEGQGETQPDDTEVKDGEGETEANAEDQCEATQGEKGADGGGESDGGDSEEEEDEEDEEEEEEEDEEEEEEENEEPLSLEWPDSRQKQAIYLFLLPIVFPLWLTIPDVRRQESRKFFVITFLGSIIWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINALQPVPVSSNGLFCAIVLLFLMLLFVIFSIASCKWRMNKILGFTMFLLYFVFLVISVMLEDRIISCPVSV
uniprot
proteins
function
FUNCTION: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. {ECO:0000250|UniProtKB:O60721}.
uniprot
proteins
mass_dalton
124667
uniprot
proteins
post_translational_modification
PTM: The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration and topology. {ECO:0000250|UniProtKB:Q28139}.
uniprot
proteins
protein_family
Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family
uniprot
proteins
protein_family
SLC24A subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
1130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q28139}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 420..440; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 465..485; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 490..510; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 531..551; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 553..573; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 939..959; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 967..987; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1003..1023; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1042..1062; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1071..1091; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1100..1120; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins