TK1
entrez
7083
canonical
uniprot
P04183
canonical
ensembl
ENSG00000167900
resolver
ensp
ENSP00000301634
resolver
ensp
ENSP00000468425
resolver
ensp
ENSP00000468556
resolver
enst
ENST00000301634
resolver
enst
ENST00000588734
resolver
enst
ENST00000590862
resolver
genesymbol
TK1
resolver
hgnc
HGNC:11830
resolver
uniprot
A0A384MDV9
resolver
uniprot
B2RC58
resolver
uniprot
K7ERV3
resolver
uniprot
K7ES52
resolver
uniprot
Q969V0
resolver
uniprot
Q9UMG9
resolver
uniprot_entry
A0A384MDV9_HUMAN
resolver
uniprot_entry
K7ERV3_HUMAN
resolver
uniprot_entry
K7ES52_HUMAN
resolver
uniprot_entry
KITH_HUMAN
resolver
uniprot_sec
B2RC58
resolver
uniprot_sec
Q969V0
resolver
uniprot_sec
Q9UMG9
resolver
amino_acid_sequence
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
uniprot
proteins
ec_number
2.7.1.21
uniprot
proteins
function
FUNCTION: Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435). Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT) (PubMed:22385435). {ECO:0000269|PubMed:22385435, ECO:0000269|PubMed:9575153, ECO:0000305|PubMed:17407781}.
uniprot
proteins
mass_dalton
25469
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="S->A: Loss of phosphorylation. Constant expression during cell cycle. No effect on ATP-induced tetramerization."; /evidence="ECO:0000269|PubMed:14697231, ECO:0000269|PubMed:14701726, ECO:0000269|PubMed:9575153"; MUTAGEN 13; /note="S->D: Perturbes ATP-induced tetramerization. Retaines the enzymatic function with decreased thymidine affinity and catalytic efficiency."; /evidence="ECO:0000269|PubMed:14697231"; MUTAGEN 28; /note="M->I,A: 300-fold higher KM for thymidine."; /evidence="ECO:0000269|PubMed:22385435"; MUTAGEN 124; /note="L->A: 30-fold higher KM for thymidine."; /evidence="ECO:0000269|PubMed:22385435"; MUTAGEN 163; /note="T->S: 50-fold higher KM for thymidine."; /evidence="ECO:0000269|PubMed:22385435"; MUTAGEN 194; /note="S->P: No effect on phosphorylation."; /evidence="ECO:0000269|PubMed:9575153"; MUTAGEN 203..205; /note="KEN->AAA: Resistant to degradation in the mitotic exit phase."; /evidence="ECO:0000269|PubMed:14701726"; MUTAGEN 203..204; /note="KE->AA: Resistant to degradation in the mitotic exit phase."; /evidence="ECO:0000269|PubMed:14701726"; MUTAGEN 203; /note="K->A: Resistant to degradation in the mitotic exit phase."; /evidence="ECO:0000269|PubMed:14701726
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-13 in mitosis. Phosphorylation of Ser-13 by CDK1 during mitosis reduces homotetramerization and catalytic efficiency when DNA replication is complete and intracellular TK1 is still present at a high level (PubMed:14697231, PubMed:9575153). {ECO:0000269|PubMed:14697231, ECO:0000269|PubMed:9575153}.; PTM: Polyubiquitinated. Postmitosis, ubiquitination leads to proteasomal degradation. The KEN box sequence located at the C-terminal region targets for degradation by the anaphase promoting complex (APC/C) activated and rate-limited by FZR1. {ECO:0000269|PubMed:14701726}.
uniprot
proteins
protein_family
Thymidine kinase family
uniprot
proteins
pubmed
14697231
uniprot
proteins
pubmed
14701726
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15611477
uniprot
proteins
pubmed
15733844
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17407781
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22385435
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
3301530
uniprot
proteins
pubmed
3785218
uniprot
proteins
pubmed
6549046
uniprot
proteins
pubmed
9575153
uniprot
proteins
sequence_length
234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins