Tnip2
entrez
231130
canonical
uniprot
Q99JG7
canonical
ensembl
ENSMUSG00000059866
resolver
ensp
ENSMUSP00000085030
resolver
enst
ENSMUST00000087737
resolver
genesymbol
Tnip2
resolver
genesymbol_syn
Abin2
resolver
uniprot
Q3TVF3
resolver
uniprot_entry
TNIP2_MOUSE
resolver
uniprot_sec
Q3TVF3
resolver
amino_acid_sequence
MSSGDPRSGRQDGAPRAAAALCGLYHEAGQQLQRLKDQLAARDALIASLRTRLAALEGHTAPSLVDALLDQVERFREQLRRQEEGASETQLRQEVERLTERLEEKEREMQQLMSQPQHEQEKEVVLLRRSVAEKEKARAASDVLCRSLADETHQLRRTLAATAHMCQHLAKCLDERQCAQGDAGEKSPAELEQTSSDASGQSVIKKLQEENRLLKQKVTHVEDLNAKWQRYDASRDEYVKGLHAQLKRRQVPLEPELMKKEISRLNRQLEEKISDCAEANQELTAMRMSRDTALERVQMLEQQILAYKDDFKSERADRERAHSRIQELEEKIMSLMYQVSQRQDSREPGPCRIHTGNKTAKYLEMDALEHVTPGGWRPESRSQQMEPSAEGGHVCTAQRGQGDLQCPHCLRCFSDEQGEAFLRHLSECCQ
uniprot
proteins
function
FUNCTION: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:11390377, ECO:0000269|PubMed:16633345}.
uniprot
proteins
mass_dalton
49094
uniprot
proteins
post_translational_modification
PTM: In vitro phosphorylated by CHUK. {ECO:0000250|UniProtKB:Q8NFZ5}.; PTM: Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probably involving deubiquitination. Deubiquitinated by USP35; leading to stabilization and inhibition of TNFalpha-induced NF-kappa-B activation. {ECO:0000250|UniProtKB:Q8NFZ5}.
uniprot
proteins
pubmed
11390377
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16633345
uniprot
proteins
sequence_length
430
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8NFZ5}.
uniprot
proteins