CALCRL
entrez
10203
canonical
uniprot
Q16602
canonical
ensembl
ENSG00000064989
resolver
ensp
ENSP00000376177
resolver
ensp
ENSP00000386972
resolver
ensp
ENSP00000387190
resolver
ensp
ENSP00000567881
resolver
ensp
ENSP00000567882
resolver
ensp
ENSP00000567883
resolver
ensp
ENSP00000567884
resolver
ensp
ENSP00000567885
resolver
ensp
ENSP00000567886
resolver
ensp
ENSP00000567887
resolver
ensp
ENSP00000567889
resolver
ensp
ENSP00000567890
resolver
ensp
ENSP00000567891
resolver
ensp
ENSP00000567892
resolver
ensp
ENSP00000567893
resolver
ensp
ENSP00000567894
resolver
ensp
ENSP00000567895
resolver
ensp
ENSP00000639680
resolver
ensp
ENSP00000639682
resolver
ensp
ENSP00000639683
resolver
ensp
ENSP00000639685
resolver
ensp
ENSP00000639686
resolver
enst
ENST00000392370
resolver
enst
ENST00000409998
resolver
enst
ENST00000410068
resolver
enst
ENST00000897822
resolver
enst
ENST00000897823
resolver
enst
ENST00000897824
resolver
enst
ENST00000897825
resolver
enst
ENST00000897826
resolver
enst
ENST00000897827
resolver
enst
ENST00000897828
resolver
enst
ENST00000897830
resolver
enst
ENST00000897831
resolver
enst
ENST00000897832
resolver
enst
ENST00000897833
resolver
enst
ENST00000897834
resolver
enst
ENST00000897835
resolver
enst
ENST00000897836
resolver
enst
ENST00000969621
resolver
enst
ENST00000969623
resolver
enst
ENST00000969624
resolver
enst
ENST00000969626
resolver
enst
ENST00000969627
resolver
genesymbol
CALCRL
resolver
genesymbol_syn
CGRPR
resolver
hgnc
HGNC:16709
resolver
uniprot
A8K6G5
resolver
uniprot
A8KAD3
resolver
uniprot
Q53S02
resolver
uniprot
Q53TS5
resolver
uniprot_entry
CALRL_HUMAN
resolver
uniprot_sec
A8K6G5
resolver
uniprot_sec
A8KAD3
resolver
uniprot_sec
Q53S02
resolver
uniprot_sec
Q53TS5
resolver
amino_acid_sequence
MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
uniprot
proteins
disease_involvement
DISEASE: Lymphatic malformation 8 (LMPHM8) [MIM:618773]: A form of primary lymphedema, a disease characterized by swelling of body parts due to developmental anomalies and functional defects of the lymphatic system. Adult patients with lymphedema may suffer from recurrent local infections. Impaired lymphatic drainage in the fetus can develop into hydrops fetalis, a severe condition characterized by excessive fluid accumulation in more than two fetal extra-vascular compartments and body cavities, placental enlargement and edema, pericardial or pleural effusion, or ascites. LMPHM8 is an autosomal recessive form characterized by onset in utero and fetal death due to non-immune hydrops fetalis. {ECO:0000269|PubMed:30115739}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs) (PubMed:32296767, PubMed:33602864, PubMed:8626685). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2 (PubMed:33602864). Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2) (PubMed:32296767, PubMed:9620797). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:32296767, PubMed:8626685). {ECO:0000269|PubMed:32296767, ECO:0000269|PubMed:33602864, ECO:0000269|PubMed:8626685, ECO:0000269|PubMed:9620797}.
uniprot
proteins
mass_dalton
52979
uniprot
proteins
mutagenesis
MUTAGEN 72; /note="W->A: Strongly reduced affinity for adrenomedullin."; /evidence="ECO:0000269|PubMed:22102369"; MUTAGEN 92; /note="F->A: Strongly reduced affinity for adrenomedullin."; /evidence="ECO:0000269|PubMed:22102369"; MUTAGEN 121; /note="W->A: Strongly reduced affinity for adrenomedullin."; /evidence="ECO:0000269|PubMed:22102369
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
20826335
uniprot
proteins
pubmed
22102369
uniprot
proteins
pubmed
30115739
uniprot
proteins
pubmed
32296767
uniprot
proteins
pubmed
33602864
uniprot
proteins
pubmed
7818539
uniprot
proteins
pubmed
8626685
uniprot
proteins
pubmed
9620797
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30115739}; Multi-pass membrane protein {ECO:0000269|PubMed:32296767}.
uniprot
proteins
transmembrane_region
TRANSMEM 140..164; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:32296767, ECO:0007744|PDB:6UUN"; TRANSMEM 176..198; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:32296767, ECO:0007744|PDB:6UUN"; TRANSMEM 210..238; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:32296767, ECO:0007744|PDB:6UUN"; TRANSMEM 253..273; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:32296767, ECO:0007744|PDB:6UUN"; TRANSMEM 290..314; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:32296767, ECO:0007744|PDB:6UUN"; TRANSMEM 330..351; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:32296767, ECO:0007744|PDB:6UUN"; TRANSMEM 367..387; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:32296767, ECO:0007744|PDB:6UUN
uniprot
proteins