Atp10b
entrez
319767
canonical
uniprot
B1AWN4
canonical
ensembl
ENSMUSG00000055415
resolver
ensp
ENSMUSP00000076844
resolver
ensp
ENSMUSP00000158770
resolver
enst
ENSMUST00000077659
resolver
enst
ENSMUST00000238415
resolver
genesymbol
Atp10b
resolver
genesymbol_syn
mKIAA0715
resolver
uniprot
A0A571BEJ2
resolver
uniprot
Q5DU18
resolver
uniprot_entry
A0A571BEJ2_MOUSE
resolver
uniprot_entry
AT10B_MOUSE
resolver
uniprot_entry
Q5DU18_MOUSE
resolver
amino_acid_sequence
MTCSLDFSWLRWKWRTQDGFSQSPSETTPLLSPETDRQSHNTAEQRVVYPNNSMCHQDWKKVCRRYPGNSICTTKYTLLTFLPQNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITIFPLATVLLIIMVKDGIEDFKRYCFDREMNSASIQIYERKEQRYMLKRWQDVRVGDFVQMQCNEIVPADILLLFSSDPSGVCHLETANLDGETNLKQRRVVKGFSQPEVQFQPEHFHSTIVCEKPNNHLSKFKGYMEHPDQTRTGFGSESLLLRGCTIRNTEVAAGIVIYAGHETKAMLNNSGPRYKRSKIERRINTDIFFCIGLLFLMCLIGAVGHSLWNGTFKEHPPFDVPDADGNFLSLALGGFYMFLTMIILLQVLIPISLYVSIELVKLGQVFLLHNDLDLYDEETDLSIQCRALNITEDLGQIQYIFSDKTGTLTENKMVFRRCTIVGSEYCHQENAKRLEMPKELDSDGEEWTQYQCLSFPPRWAQGSTTMRSQGGAQPLRRCHSARVPIQSHCRQRSVGRWETSQPPVAFSSSIEKDVTPDKNLLSKVRDAALWLETSDTRPAKPSHSTTASIADFFLALTICNSVMVSTTTEPRKRVTTPPANKALGTSLEKIQQLFQRLKLLSLSQSFSSTAPSDTDLGESLGPNLPTIDSDEKDDTSVCSGDCSTDGGYRSSTWEQGDILGSESGTSLEEGLEAPTLSQDEPELCYEAESPDEAALVHAARAYSFTLVSRTPEQVTVRLPQGICLTFDLLFTLGFDSVRKRMSVVVRHPLTDEIIVYTKGADSVIMDLLEDPACESNIDVEKKLKRIRARTQKHLDLYARDGLRTLCIAKKVVDEEDFQRWASFRREAEASLDNREELLMETAQHLENHLTLLGATGIEDRLQEGVPDTIAALREAGIQLWVLTGDKQETAVNIAYSCKLLDQTDTVYSINTENQETCESILNCTLEDIKRFHEPQQPARKLCGHRIPPKMPSVNSGAMAPEIGLVIDGKTLNAIFQGKLENKFLELTQYCRSVLCCRSTPLQKSMIVKLVRDKLSVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMSSDFAIARFSHLKKLLLVHGHWCYSRLARMVVYYFYKNVCYVNLLFWYQFFCGFSGSTMIDYWQMIFFNLFFTSLPPIIFGVLDKDVSAETLLALPELYKSGQNSECYNLPTFWVSMADAFYQSLICFFIPYLTYRGSDIDVFTFGTPINTISLTTILLHQAMEMKTWTVLHGLVLLGSFLMYFVVSLIYNATCVTCNSPTNPYWVMERQLSDPTFYLICLLTPVVALLPRYFLLSLQGTYGKSLISKAQKIDKLPIDKRNLEIQNWRSKQRPAPASASASASAPATGTVHTRPPCHPVPPEAQQNFGASTSKSSGPPRQKHVEDRVLQDPRCSREHSRDDTCTVDTLAKLSSGECLLDPNRTVAPTAYSRGQKDVSRHSSKGSHRRSQSSLTI
uniprot
proteins
ec_number
7.6.2.1
uniprot
proteins
function
FUNCTION: Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes (By similarity). Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons (PubMed:32172343). {ECO:0000250|UniProtKB:O94823, ECO:0000269|PubMed:32172343}.
uniprot
proteins
mass_dalton
166437
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated at the conserved aspartate of the P-type ATPase signature sequence. {ECO:0000250|UniProtKB:O94823}.
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IV subfamily
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
32172343
uniprot
proteins
sequence_length
1474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:32172343}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:32172343}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O94823}; Multi-pass membrane protein {ECO:0000255}. Note=Exit from the endoplasmic reticulum requires the presence of CDC50A, but not CDC50B. {ECO:0000250|UniProtKB:O94823}.
uniprot
proteins
transmembrane_region
TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 317..337; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 361..381; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1120..1140; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1143..1163; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1193..1213; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1220..1240; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1250..1270; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1295..1315; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins