SLC38A4
entrez
55089
canonical
uniprot
Q969I6
canonical
ensembl
ENSG00000139209
resolver
ensp
ENSP00000266579
resolver
ensp
ENSP00000389843
resolver
ensp
ENSP00000545548
resolver
ensp
ENSP00000545549
resolver
ensp
ENSP00000545550
resolver
ensp
ENSP00000545551
resolver
ensp
ENSP00000545552
resolver
ensp
ENSP00000545553
resolver
ensp
ENSP00000545554
resolver
ensp
ENSP00000545555
resolver
ensp
ENSP00000545557
resolver
ensp
ENSP00000545558
resolver
ensp
ENSP00000545559
resolver
ensp
ENSP00000545560
resolver
ensp
ENSP00000545561
resolver
ensp
ENSP00000545562
resolver
ensp
ENSP00000545563
resolver
ensp
ENSP00000545564
resolver
ensp
ENSP00000545565
resolver
ensp
ENSP00000545566
resolver
ensp
ENSP00000545567
resolver
ensp
ENSP00000545568
resolver
ensp
ENSP00000545572
resolver
ensp
ENSP00000545573
resolver
ensp
ENSP00000545576
resolver
ensp
ENSP00000545577
resolver
ensp
ENSP00000603743
resolver
enst
ENST00000266579
resolver
enst
ENST00000447411
resolver
enst
ENST00000875489
resolver
enst
ENST00000875490
resolver
enst
ENST00000875491
resolver
enst
ENST00000875492
resolver
enst
ENST00000875493
resolver
enst
ENST00000875494
resolver
enst
ENST00000875495
resolver
enst
ENST00000875496
resolver
enst
ENST00000875498
resolver
enst
ENST00000875499
resolver
enst
ENST00000875500
resolver
enst
ENST00000875501
resolver
enst
ENST00000875502
resolver
enst
ENST00000875503
resolver
enst
ENST00000875504
resolver
enst
ENST00000875505
resolver
enst
ENST00000875506
resolver
enst
ENST00000875507
resolver
enst
ENST00000875508
resolver
enst
ENST00000875509
resolver
enst
ENST00000875513
resolver
enst
ENST00000875514
resolver
enst
ENST00000875517
resolver
enst
ENST00000875518
resolver
enst
ENST00000933684
resolver
genesymbol
SLC38A4
resolver
genesymbol_syn
ATA3
resolver
genesymbol_syn
NAT3
resolver
genesymbol_syn
SNAT4
resolver
hgnc
HGNC:14679
resolver
uniprot
A8K553
resolver
uniprot_entry
S38A4_HUMAN
resolver
uniprot_sec
A8K553
resolver
amino_acid_sequence
MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSSQFANEDTESQKFLTNGFLGKKKLADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSLYSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEVIRAFMGLEENTGEWYLNGNYLIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSVVIYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNSESSDVNFMMDYTHRNPAGLDENQAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPIYSELKDRSRRKMQTVSNISITGMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPLLMVRLAVLVAVTLTVPIVLFPIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVILVPTIKYIFGFIGASSATMLIFILPAVFYLKLVKKETFRSPQKVGALIFLVVGIFFMIGSMALIIIDWIYDPPNSKHH
uniprot
proteins
function
FUNCTION: Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:11342143, PubMed:19015196, PubMed:33928121). The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+) (PubMed:11414754). Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L-proline and L-glutamine and L-methionine (PubMed:11414754, PubMed:33928121). {ECO:0000269|PubMed:11342143, ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:19015196, ECO:0000269|PubMed:33928121}.
uniprot
proteins
mass_dalton
60764
uniprot
proteins
post_translational_modification
PTM: The disulfide bond plays an important role in substrate transport, but has no effect on trafficking to the cell surface. {ECO:0000250|UniProtKB:Q8R1S9}.
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
pubmed
11342143
uniprot
proteins
pubmed
11414754
uniprot
proteins
pubmed
12845534
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16148032
uniprot
proteins
pubmed
19015196
uniprot
proteins
pubmed
21917917
uniprot
proteins
pubmed
29961568
uniprot
proteins
pubmed
33928121
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:16148032}; Multi-pass membrane protein {ECO:0000269|PubMed:11414754}. Cell projection, microvillus membrane {ECO:0000269|PubMed:19015196}; Multi-pass membrane protein. Note=Microvillus membrane localization in placenta. {ECO:0000269|PubMed:19015196}.
uniprot
proteins
transmembrane_region
TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 152..172; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 221..241; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 333..353; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 370..390; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 412..432; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 454..474; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 477..497; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 515..535; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins