Pgrmc2
entrez
361940
canonical
uniprot
Q5XIU9
canonical
ensembl
ENSRNOG00000014051
resolver
ensembl
ENSRNOG00055002324
resolver
ensembl
ENSRNOG00060006942
resolver
ensembl
ENSRNOG00065002470
resolver
ensp
ENSRNOP00000018796
resolver
ensp
ENSRNOP00055002791
resolver
ensp
ENSRNOP00060008483
resolver
ensp
ENSRNOP00065002215
resolver
enst
ENSRNOT00000018796
resolver
enst
ENSRNOT00055003704
resolver
enst
ENSRNOT00060011357
resolver
enst
ENSRNOT00065003246
resolver
genesymbol
Pgrmc2
resolver
uniprot_entry
PGRC2_RAT
resolver
amino_acid_sequence
MAAGDGDVKLSTLGSGGERGGDGSPGGAGATAARSSWVAALLATGGEMLLNVALVALVLLGAYRLWVRWGRRGLCSGPGAGEESPAATLPRMKKRDFSLEQLRQYDGARTPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHSKQD
uniprot
proteins
function
FUNCTION: Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non-classical progesterone receptor in the uterus. Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1. {ECO:0000250|UniProtKB:Q80UU9}.
uniprot
proteins
mass_dalton
23403
uniprot
proteins
protein_family
Cytochrome b5 family
uniprot
proteins
protein_family
MAPR subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q80UU9}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q80UU9}. Nucleus envelope {ECO:0000250|UniProtKB:O15173}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O15173}. Secreted {ECO:0000250|UniProtKB:O15173}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..62; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins