Il12a
entrez
16159
canonical
uniprot
P43431
canonical
ensembl
ENSMUSG00000027776
resolver
ensp
ENSMUSP00000029345
resolver
ensp
ENSMUSP00000103446
resolver
enst
ENSMUST00000029345
resolver
enst
ENSMUST00000107816
resolver
genesymbol
Il12a
resolver
genesymbol_syn
IL12A
resolver
genesymbol_syn
Ll12a
resolver
uniprot
F8WI71
resolver
uniprot
Q549G3
resolver
uniprot_entry
F8WI71_MOUSE
resolver
uniprot_entry
IL12A_MOUSE
resolver
uniprot_entry
Q549G3_MOUSE
resolver
amino_acid_sequence
MCQSRYLLFLATLALLNHLSLARVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSA
uniprot
proteins
function
FUNCTION: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity (PubMed:8766560). Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and also functions as an immune-suppressive cytokine (PubMed:18033300, PubMed:30197594). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity). {ECO:0000250|UniProtKB:P29459, ECO:0000269|PubMed:18033300, ECO:0000269|PubMed:30197594, ECO:0000269|PubMed:8766560}.
uniprot
proteins
mass_dalton
24179
uniprot
proteins
protein_family
IL-6 superfamily
uniprot
proteins
pubmed
1350290
uniprot
proteins
pubmed
18033300
uniprot
proteins
pubmed
30197594
uniprot
proteins
pubmed
34374750
uniprot
proteins
pubmed
8557982
uniprot
proteins
pubmed
8647196
uniprot
proteins
pubmed
8766560
uniprot
proteins
sequence_length
215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1350290, ECO:0000269|PubMed:34374750}.
uniprot
proteins