Srsf2
entrez
20382
canonical
uniprot
Q62093
canonical
ensembl
ENSMUSG00000034120
resolver
ensp
ENSMUSP00000090059
resolver
ensp
ENSMUSP00000120086
resolver
ensp
ENSMUSP00000140016
resolver
ensp
ENSMUSP00000222672
resolver
ensp
ENSMUSP00000222674
resolver
enst
ENSMUST00000092404
resolver
enst
ENSMUST00000136914
resolver
enst
ENSMUST00000190993
resolver
genesymbol
Srsf2
resolver
genesymbol_syn
Pr264
resolver
genesymbol_syn
Sfrs10
resolver
genesymbol_syn
Sfrs2
resolver
uniprot
Q542L3
resolver
uniprot
Q60701
resolver
uniprot_entry
SRSF2_MOUSE
resolver
uniprot_sec
Q542L3
resolver
uniprot_sec
Q60701
resolver
amino_acid_sequence
MSYGRPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVYIPRDRYTKESRGFAFVRFHDKRDAEDAMDAMDGAVLDGRELRVQMARYGRPPDSHHSRRGPPPRRYGGGGYGRRSRSPRRRRRSRSRSRSRSRSRSRSRYSRSKSRSRTRSRSRSTSKSRSARRSKSKSSSVSRSRSRSRSRSRSRSPPPVSKRESKSRSRSKSPPKSPEEEGAVSS
uniprot
proteins
function
FUNCTION: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment (By similarity). Can bind to the myelin basic protein (MBP) gene MB3 regulatory region and increase transcription of the mbp promoter in cells derived from the CNS (PubMed:7527040). {ECO:0000250|UniProtKB:Q01130, ECO:0000269|PubMed:7527040}.
uniprot
proteins
mass_dalton
25476
uniprot
proteins
post_translational_modification
PTM: Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by SRPK2 and this causes its redistribution from the nuclear speckle to nucleoplasm and controls cell fate decision in response to cisplatin treatment. KAT5/TIP60 inhibits its phosphorylation by preventing SRPK2 nuclear translocation. {ECO:0000250|UniProtKB:Q01130}.; PTM: Acetylation on Lys-52 by KAT5/TIP60 promotes its proteasomal degradation. This effect is counterbalanced by HDAC6, which positively controls SRSF2 protein level by deacetylating it and preventing its proteasomal degradation. {ECO:0000250|UniProtKB:Q01130}.
uniprot
proteins
protein_family
Splicing factor SR family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22570411
uniprot
proteins
pubmed
7527040
uniprot
proteins
pubmed
9774382
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q01130}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q01130}. Nucleus speckle {ECO:0000250|UniProtKB:Q01130}. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear speckle to nucleoplasm. {ECO:0000250|UniProtKB:Q01130}.
uniprot
proteins