Pex2
entrez
29534
canonical
uniprot
P24392
canonical
ensembl
ENSRNOG00000008748
resolver
ensp
ENSRNOP00000076831
resolver
ensp
ENSRNOP00000100149
resolver
ensp
ENSRNOP00000108095
resolver
enst
ENSRNOT00000095560
resolver
enst
ENSRNOT00000131413
resolver
enst
ENSRNOT00000151330
resolver
genesymbol
Pex2
resolver
genesymbol_syn
Paf1
resolver
genesymbol_syn
Pmp35
resolver
genesymbol_syn
Pxmp3
resolver
uniprot
Q63733
resolver
uniprot_entry
PEX2_RAT
resolver
uniprot_sec
Q63733
resolver
amino_acid_sequence
MAAREESTQSANRVLRISQLDALELNKALEQLVWSQFTQCFHGFKPGLLARFEPEVKAFLWLFLWRFTIYSKNATVGQSVLNIQYKNDSSPNPVYQPPSKNQKLLYAVCTIGGRWLEERCYDLFRNRHLASFGKAKQCMNFVVGLLKLGELMNFLIFLQKGKFATLTERLLGIHSVFCKPQSMREVGFEYMNRELLWHGFAEFLVFLLPLINIQKLKAKLSSWCIPLTSTAGSDSTLGSSGKECALCGEWPTMPHTIGCEHVFCYYCVKSSFLFDMYFTCPKCGTEVHSVQPLKSGIEMSEVNAL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
ec_number
2.3.2.36
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:1750930). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase. PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity). Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70. Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis (By similarity). {ECO:0000250|UniProtKB:P28328, ECO:0000250|UniProtKB:P32800, ECO:0000269|PubMed:1750930}.
uniprot
proteins
mass_dalton
34768
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:P28328}.
uniprot
proteins
post_translational_modification
PTM: Forms intramolecular and intermolecular disulfide bonds in response to reactive oxygen species (ROS), promoting higher stability. {ECO:0000250|UniProtKB:P28328}.
uniprot
proteins
protein_family
Pex2/pex10/pex12 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1750930
uniprot
proteins
pubmed
8035823
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:1750930}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..42; /note="Helical; Name=TM1"; /evidence="ECO:0000250|UniProtKB:G2Q1C9"; TRANSMEM 49..74; /note="Helical; Name=TM2"; /evidence="ECO:0000250|UniProtKB:G2Q1C9"; TRANSMEM 99..125; /note="Helical; Name=TM3"; /evidence="ECO:0000250|UniProtKB:G2Q1C9"; TRANSMEM 134..160; /note="Helical; Name=TM4"; /evidence="ECO:0000250|UniProtKB:G2Q1C9"; TRANSMEM 188..211; /note="Helical; Name=TM5"; /evidence="ECO:0000250|UniProtKB:G2Q1C9
uniprot
proteins