Ctla4
entrez
12477
canonical
uniprot
P09793
canonical
ensembl
ENSMUSG00000026011
resolver
ensp
ENSMUSP00000027164
resolver
ensp
ENSMUSP00000095327
resolver
enst
ENSMUST00000027164
resolver
enst
ENSMUST00000097720
resolver
genesymbol
Ctla4
resolver
genesymbol_syn
Cd152
resolver
uniprot
F6YVT8
resolver
uniprot
Q5SSM0
resolver
uniprot
Q6GTR6
resolver
uniprot
Q9QZZ7
resolver
uniprot_entry
CTLA4_MOUSE
resolver
uniprot_entry
F6YVT8_MOUSE
resolver
uniprot_entry
Q5SSM0_MOUSE
resolver
uniprot_entry
Q6GTR6_MOUSE
resolver
uniprot_sec
Q9QZZ7
resolver
amino_acid_sequence
MACLGLRRYKAQLQLPSRTWPFVALLTLLFIPVFSEAIQVTQPSVVLASSHGVASFPCEYSPSHNTDEVRVTVLRQTNDQMTEVCATTFTEKNTVGFLDYPFCSGTFNESRVNLTIQGLRAVDTGLYLCKVELMYPPPYFVGMGNGTQIYVIDPEPCPDSDFLLWILVAVSLGLFFYSFLVSAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN
uniprot
proteins
function
FUNCTION: Inhibitory receptor acting as a major negative regulator of T-cell responses. Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. {ECO:0000250|UniProtKB:P16410}.
uniprot
proteins
mass_dalton
24993
uniprot
proteins
post_translational_modification
PTM: N-glycosylation is important for dimerization. {ECO:0000250|UniProtKB:P16410}.; PTM: Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface. {ECO:0000250|UniProtKB:P16410}.
uniprot
proteins
pubmed
10493833
uniprot
proteins
pubmed
11052947
uniprot
proteins
pubmed
1713603
uniprot
proteins
pubmed
3496540
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P16410}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P16410}. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalization. {ECO:0000250|UniProtKB:P16410}.
uniprot
proteins
transmembrane_region
TRANSMEM 162..182; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins