BCAM
entrez
4059
canonical
uniprot
P50895
canonical
ensembl
ENSG00000187244
resolver
ensp
ENSP00000270233
resolver
ensp
ENSP00000481153
resolver
enst
ENST00000270233
resolver
enst
ENST00000611077
resolver
genesymbol
BCAM
resolver
genesymbol_syn
LU
resolver
genesymbol_syn
MSK19
resolver
hgnc
HGNC:6722
resolver
uniprot
A0A087WXM8
resolver
uniprot
A8MYF9
resolver
uniprot
A9YWT5
resolver
uniprot
A9YWT6
resolver
uniprot
Q86VC7
resolver
uniprot_entry
A0A087WXM8_HUMAN
resolver
uniprot_entry
BCAM_HUMAN
resolver
uniprot_sec
A8MYF9
resolver
uniprot_sec
A9YWT5
resolver
uniprot_sec
A9YWT6
resolver
uniprot_sec
Q86VC7
resolver
amino_acid_sequence
MEPPDAPAQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVAVSVGLLLLVVAVFYCVRRKGGPCCRQRREKGAPPPGEPGLSHSGSEQPEQTGLLMGGASGGARGGSGGFGDEC
uniprot
proteins
function
FUNCTION: Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion (PubMed:9616226, PubMed:31413112). Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction (PubMed:17158232). Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion (PubMed:15975931). Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR (PubMed:23160466). {ECO:0000269|PubMed:15975931, ECO:0000269|PubMed:17158232, ECO:0000269|PubMed:23160466, ECO:0000269|PubMed:31413112, ECO:0000269|PubMed:9616226}.
uniprot
proteins
mass_dalton
67405
uniprot
proteins
mutagenesis
MUTAGEN 584; /note="E->A: Extremely reduced binding to spectrins; when associated with A-585."; /evidence="ECO:0000269|PubMed:15238148"; MUTAGEN 585; /note="K->A: Extremely reduced binding to spectrins; when associated with A-584."; /evidence="ECO:0000269|PubMed:15238148"; MUTAGEN 621; /note="S->A: Dramatically reduced cell adhesion."; /evidence="ECO:0000269|PubMed:15975931, ECO:0000269|PubMed:31413112
uniprot
proteins
post_translational_modification
PTM: Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin. Ser-621 can also be phosphorylated by AKT1 (PubMed:23160466, PubMed:31413112). {ECO:0000269|PubMed:15975931, ECO:0000269|PubMed:23160466, ECO:0000269|PubMed:31413112}.
uniprot
proteins
pubmed
12754519
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15238148
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15975931
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
17158232
uniprot
proteins
pubmed
17319831
uniprot
proteins
pubmed
17638854
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23160466
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
31413112
uniprot
proteins
pubmed
7777537
uniprot
proteins
pubmed
7954395
uniprot
proteins
pubmed
9166867
uniprot
proteins
pubmed
9192786
uniprot
proteins
pubmed
9616226
uniprot
proteins
sequence_length
628
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15238148, ECO:0000269|PubMed:31413112}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 548..568; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins