TRPC1
entrez
7220
canonical
uniprot
P48995
canonical
ensembl
ENSG00000144935
resolver
ensp
ENSP00000273482
resolver
ensp
ENSP00000419313
resolver
genesymbol
TRPC1
resolver
genesymbol_syn
TRP1
resolver
hgnc
HGNC:12333
resolver
uniprot
Q14CE4
resolver
uniprot_entry
TRPC1_HUMAN
resolver
uniprot_sec
Q14CE4
resolver
activity_regulation
ACTIVITY REGULATION: May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G protein coupled receptors (PubMed:15016832). Also activated by intracellular calcium store depletion (PubMed:8663995). Inhibited by xanthine-based inhibitor Pico145 (PubMed:39478185). {ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:39478185, ECO:0000269|PubMed:8663995}.
uniprot
proteins
amino_acid_sequence
MMAALYPSTDLSGASSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENENLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN
uniprot
proteins
function
FUNCTION: Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11139478, PubMed:15016832, PubMed:39478185). Forms a heteromeric ion channel with TRPC4 or TRPC5 that has reduced calcium permeability compared to the homomeric TRPC4 or TRPC5 channel (PubMed:39478185). Also permeable to monovalent ions including sodium, lithium and cesium ions (PubMed:39478185). {ECO:0000269|PubMed:11139478, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:39478185}.; FUNCTION: [Isoform Short]: Forms a receptor-activated non-selective calcium permeant cation channel. Also activated by intracellular calcium store depletion. {ECO:0000269|PubMed:8663995}.
uniprot
proteins
mass_dalton
91212
uniprot
proteins
mutagenesis
MUTAGEN 601; /note="L->G: Decreases permeability to calcium ions and increases permeability to cesium ions."; /evidence="ECO:0000269|PubMed:39478185"; MUTAGEN 646; /note="H->N: Decreases permeability to calcium ions and increases permeability to cesium ions."; /evidence="ECO:0000269|PubMed:39478185"; MUTAGEN 647; /note="K->N: Decreases permeability to calcium ions."; /evidence="ECO:0000269|PubMed:39478185
uniprot
proteins
post_translational_modification
PTM: Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells. {ECO:0000269|PubMed:15016832}.
uniprot
proteins
protein_family
STrpC subfamily
uniprot
proteins
protein_family
TRPC1 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
10766822
uniprot
proteins
pubmed
11139478
uniprot
proteins
pubmed
12032305
uniprot
proteins
pubmed
15016832
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15757897
uniprot
proteins
pubmed
16883570
uniprot
proteins
pubmed
17850865
uniprot
proteins
pubmed
19193631
uniprot
proteins
pubmed
19850920
uniprot
proteins
pubmed
19945390
uniprot
proteins
pubmed
39478185
uniprot
proteins
pubmed
7568191
uniprot
proteins
pubmed
7589464
uniprot
proteins
pubmed
8663995
uniprot
proteins
pubmed
9215637
uniprot
proteins
sequence_length
793
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11139478}; Multi-pass membrane protein {ECO:0000269|PubMed:39478185}.
uniprot
proteins
transmembrane_region
TRANSMEM 387..404; /note="Helical; Name=S1"; /evidence="ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM"; TRANSMEM 423..439; /note="Helical; Name=S2"; /evidence="ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM"; TRANSMEM 456..475; /note="Helical; Name=S3"; /evidence="ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM"; TRANSMEM 497..517; /note="Helical; Name=S4"; /evidence="ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM"; TRANSMEM 537..558; /note="Helical; Name=S5"; /evidence="ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM"; TRANSMEM 624..644; /note="Helical; Name=S6"; /evidence="ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM
uniprot
proteins