Mylip
entrez
218203
canonical
uniprot
Q8BM54
canonical
ensembl
ENSMUSG00000038175
resolver
ensp
ENSMUSP00000047403
resolver
genesymbol
Mylip
resolver
uniprot
Q3TX01
resolver
uniprot
Q8BLY9
resolver
uniprot
Q91Z47
resolver
uniprot_entry
MYLIP_MOUSE
resolver
uniprot_sec
Q3TX01
resolver
uniprot_sec
Q8BLY9
resolver
uniprot_sec
Q91Z47
resolver
activity_regulation
ACTIVITY REGULATION: Can bind 1 iron ion per dimer. Iron binding seems to decrease LDLR degradation activity. {ECO:0000250|UniProtKB:Q8WY64}.
uniprot
proteins
amino_acid_sequence
MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKESLLAGHLQCSPEQAVELSALLAQTKFGDYNQNTAQYSYEDLCEKELSSSTLNSIVAKHKELEGISQASAEYQVLQIVSAMENYGIEWHAVRDSEGQKLLIGVGPEGISICKEDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRSDQSPPSSPLKSSDSSMSCSSCEGLSCQQTRVLQEKLRKLKEAMLCMACCEEEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. {ECO:0000269|PubMed:19520913, ECO:0000269|PubMed:20427281}.
uniprot
proteins
mass_dalton
49849
uniprot
proteins
mutagenesis
MUTAGEN 387; /note="C->A: Loss of ubiquitin ligase activity."; /evidence="ECO:0000269|PubMed:19520913
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000305|PubMed:19520913}.
uniprot
proteins
pubmed
14651927
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19520913
uniprot
proteins
pubmed
20427281
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q8WY64}; Peripheral membrane protein.
uniprot
proteins