PLEKHG3
entrez
26030
canonical
uniprot
A1L390
canonical
ensembl
ENSG00000126822
resolver
ensp
ENSP00000247226
resolver
genesymbol
PLEKHG3
resolver
genesymbol_syn
KIAA0599
resolver
hgnc
HGNC:20364
resolver
uniprot
A1L389
resolver
uniprot
B5MEC9
resolver
uniprot
O60339
resolver
uniprot
Q6GMS3
resolver
uniprot
Q6P4B1
resolver
uniprot
Q7L3S3
resolver
uniprot
Q86SW7
resolver
uniprot
Q8TEF5
resolver
uniprot
Q96EW6
resolver
uniprot
Q9BT82
resolver
uniprot_entry
PKHG3_HUMAN
resolver
uniprot_sec
A1L389
resolver
uniprot_sec
B5MEC9
resolver
uniprot_sec
O60339
resolver
uniprot_sec
Q6GMS3
resolver
uniprot_sec
Q6P4B1
resolver
uniprot_sec
Q7L3S3
resolver
uniprot_sec
Q86SW7
resolver
uniprot_sec
Q8TEF5
resolver
uniprot_sec
Q96EW6
resolver
uniprot_sec
Q9BT82
resolver
amino_acid_sequence
MPVSTSLHQDGSQERPVSLTSTTSSSGSSCDSRSAMEEPSSSEAPAKNGAGSLRSRHLPNSNNNSSSWLNVKGPLSPFNSRAAAGPAHHKLSYLGRVVREIVETERMYVQDLRSIVEDYLLKIIDTPGLLKPEQVSALFGNIENIYALNSQLLRDLDSCNSDPVAVASCFVERSQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTYGELVLEGTFRVHRVRNERTFFLFDKTLLITKKRGDHFVYKGNIPCSSLMLIESTRDSLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIKRLILENHHATIPQKAKEAILEMDSYYPNRYRCSPERLKKAWSSQDEVSTNVRQGRRQSEPTKHLLRQLNEKARAAGMKGKGRRESESSRSSRRPSGRSPTSTEKRMSFESISSLPEVEPDPEAGSEQEVFSAVEGPSAEETPSDTESPEVLETQLDAHQGLLGMDPPGDMVDFVAAESTEDLKALSSEEEEEMGGAAQEPESLLPPSVLDQASVIAERFVSSFSRRSSVAQEDSKSSGFGSPRLVSRSSSVLSLEGSEKGLARHGSATDSLSCQLSPEVDISVGVATEDSPSVNGMEPPSPGCPVEPDRSSCKKKESALSTRDRLLLDKIKSYYENAEHHDAGFSVRRRESLSYIPKGLVRNSISRFNSLPRPDPEPVPPVGSKRQVGSRPTSWALFELPGPSQAVKGDPPPISDAEFRPSSEIVKIWEGMESSGGSPGKGPGQGQANGFDLHEPLFILEEHELGAITEESATASPESSSPTEGRSPAHLARELKELVKELSSSTQGELVAPLHPRIVQLSHVMDSHVSERVKNKVYQLARQYSLRIKSNKPVMARPPLQWEKVAPERDGKSPTVPCLQEEAGEPLGGKGKRKPVLSLFDYEQLMAQEHSPPKPSSAGEMSPQRFFFNPSAVSQRTTSPGGRPSARSPLSPTETFSWPDVRELCSKYASRDEARRAGGGRPRGPPVNRSHSVPENMVEPPLSGRVGRCRSLSTKRGRGGGEAAQSPGPLPQSKPDGGETLYVTADLTLEDNRRVIVMEKGPLPSPTAGLEESSGQGPSSPVALLGQVQDFQQSAECQPKEEGSRDPADPSQQGRVRNLREKFQALNSVG
uniprot
proteins
function
FUNCTION: Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}.
uniprot
proteins
mass_dalton
134412
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27555588
uniprot
proteins
pubmed
9455484
uniprot
proteins
sequence_length
1219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:27555588}. Note=Colocalizes with actin at the leading edge of polarized cells. {ECO:0000269|PubMed:27555588}.
uniprot
proteins