Tmem53
entrez
68777
canonical
uniprot
Q9D0Z3
canonical
ensembl
ENSMUSG00000048772
resolver
ensp
ENSMUSP00000061523
resolver
ensp
ENSMUSP00000102041
resolver
ensp
ENSMUSP00000102042
resolver
ensp
ENSMUSP00000121458
resolver
genesymbol
Tmem53
resolver
genesymbol_syn
Net4
resolver
uniprot
A2AE66
resolver
uniprot
Q8VDW5
resolver
uniprot
Q9DAF0
resolver
uniprot_entry
TMM53_MOUSE
resolver
uniprot_sec
A2AE66
resolver
uniprot_sec
Q8VDW5
resolver
uniprot_sec
Q9DAF0
resolver
amino_acid_sequence
MASAELDYSIEIPDQPCWSQKNRQGGKEAGKQQPVVILLGWGGCRDKNLAKYSAIYHKRGCIVIRYTAPWHMVFFSESLGIPSLRVIAQKLLELLFDYEIEREPLLFHVFSNAGVMLYRYVLELLQTHQRFRHLHVVGTIFDSGPGDSNLIGALRALATILERRPAVLRLLLLAAFALVVILFHFLLAPFTALFHTHFYDRLQDSGSCWPELYLYSRADKVVSARDVERMVEARLAHQVMVRGVDFVSSAHVSHLRDYPTYYTSLCVDFMHNCVQC
uniprot
proteins
function
FUNCTION: Negatively regulates bone morphogenetic protein (BMP) signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of phosphorylated SMAD1/5/9 proteins. {ECO:0000269|PubMed:33824347}.
uniprot
proteins
mass_dalton
31589
uniprot
proteins
protein_family
TMEM53 family
uniprot
proteins
pubmed
12958361
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20091084
uniprot
proteins
pubmed
33824347
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000269|PubMed:12958361, ECO:0000269|PubMed:20091084}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins