Kcnj9
entrez
116560
canonical
uniprot
Q63511
canonical
ensembl
ENSRNOG00055021892
resolver
ensembl
ENSRNOG00060022766
resolver
ensp
ENSRNOP00055030648
resolver
ensp
ENSRNOP00060032675
resolver
enst
ENSRNOT00055037575
resolver
enst
ENSRNOT00060039489
resolver
genesymbol
Kcnj9
resolver
genesymbol_syn
Girk3
resolver
uniprot_entry
KCNJ9_RAT
resolver
amino_acid_sequence
MAQENAAFSPGSEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRYLTDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGMTCQARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDAHLYWSIPSRLDEKVEEEGAGEGAGAGDGADKEQNGCLPPPESESKV
uniprot
proteins
function
FUNCTION: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Unable to produce channel activity when expressed alone but forms a functional channel in association with KCNJ3/GIRK1. {ECO:0000269|PubMed:8670306}.
uniprot
proteins
mass_dalton
43965
uniprot
proteins
mutagenesis
MUTAGEN 388..389; /note="ES->RR,RS: Abolishes interaction with SNX27."; /evidence="ECO:0000269|PubMed:21422294"; MUTAGEN 390..393; /note="Missing: Abolishes interaction with SNX27."; /evidence="ECO:0000269|PubMed:17828261"; MUTAGEN 392; /note="K->D: Abolishes interaction with SNX27."; /evidence="ECO:0000269|PubMed:17828261"; MUTAGEN 392; /note="K->E: Does not affect interaction with SNX27."; /evidence="ECO:0000269|PubMed:17828261"; MUTAGEN 393; /note="V->I: Abolishes interaction with SNX27."; /evidence="ECO:0000269|PubMed:17828261
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ9 subfamily
uniprot
proteins
pubmed
17828261
uniprot
proteins
pubmed
21422294
uniprot
proteins
pubmed
8670306
uniprot
proteins
sequence_length
393
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..82; /note="Helical; Name=M1"; /evidence="ECO:0000250"; TRANSMEM 135..156; /note="Helical; Name=M2"; /evidence="ECO:0000250
uniprot
proteins