Rnf220
entrez
66743
canonical
uniprot
Q6PDX6
canonical
ensembl
ENSMUSG00000028677
resolver
ensp
ENSMUSP00000030439
resolver
ensp
ENSMUSP00000092449
resolver
ensp
ENSMUSP00000099751
resolver
ensp
ENSMUSP00000152367
resolver
ensp
ENSMUSP00000281989
resolver
ensp
ENSMUSP00000281990
resolver
ensp
ENSMUSP00000281993
resolver
ensp
ENSMUSP00000281994
resolver
enst
ENSMUST00000094853
resolver
genesymbol
Rnf220
resolver
uniprot
A2APP0
resolver
uniprot
F6T696
resolver
uniprot
Q3T9M4
resolver
uniprot
Q3V3D7
resolver
uniprot
Q8JZY5
resolver
uniprot
Q9D4L6
resolver
uniprot_entry
F6T696_MOUSE
resolver
uniprot_entry
Q9D4L6_MOUSE
resolver
uniprot_entry
RN220_MOUSE
resolver
uniprot_sec
A2APP0
resolver
uniprot_sec
Q3T9M4
resolver
uniprot_sec
Q3V3D7
resolver
uniprot_sec
Q8JZY5
resolver
amino_acid_sequence
MDLHRAAFKMENSSYLPNPLASPALMVLASTAEASRDASIPCQQPRPFGVPVSVDKDVHIPFTNGSYTFASMYHRQGGVPGTFANRDFPPSLLHLHPQFAPPNLDCTPISMLNHSGVGAFRPFASTEDRESYQSAFTPAKRLKNCHDTESPHLRFSDADGKEYDFGTQLPSSSPGSLKVDDTGKKIFAVSGLISDRETSSSPEDRNDRCKKKAVALFDSQAPLCPICQVLLRPSELQEHMEQELEQLAQLPASKNSLLKDAMAPGTPKSLLLSASIKREGDSPTASPHSSATEDLHHSDRYQTFLRVRANRQTRLNARIGKMKRRKQDEGQREGSCMAEDDAVDIEHADSNRFEEYEWCGQKRIRATTLLEGGFRGSGFVMCSGKENPDSDADLDVDGDDTLEYGKPQYTEADVIPCTGEEPGEAKEREALRGAVLNGGPPSTRITPEFSKWASDEMPSTSNGEGSKQEAMQKTCKNSDIEKITEESAVTTFEALKARVRELERQLSRGDRYKCLICMDSYSMPLTSIQCWHVHCEECWLRTLGAKKLCPQCNTITAPGDLRRIYL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of multiple substrates including GRIA1, GRIA2, PHOX2A and PHOX2B, STAT1, STAT3 and SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling. Plays a critical role in the regulation of nuclear lamina. Modulates synaptic activity and brain functions by promoting degradation of AMPA receptor subunits GRIA1 and GRIA2 (PubMed:36179027). The RNF220/ZC4H2 complex monoubiquitinates PHOX2A and PHOX2B to enhance their DNA-binding ability and transactivity (PubMed:32094113). Promotes 'Lys-63'-linked polyubiquitination of Gli transcriptional activators and repressors, facilitating their nuclear export by CRM1 to fine-tune the sonic hedgehog/Gli signaling (By similarity). Regulates type I and type II interferon responses upon viral or bacterial infection by mediating 'Lys-63'-linked polyubiquitination of STAT1 (PubMed:32814877). Also regulates STAT3 phosphorylation, nuclear translocation, and transcriptional activity via ubiquitination (By similarity). Promotes OLIG1 and OLIG2 'Lys-63'-linked polyubiquitination and stabilization, two master regulatory transcription factors involved in oligodendroglial development (By similarity). {ECO:0000250|UniProtKB:Q5VTB9, ECO:0000269|PubMed:31291587, ECO:0000269|PubMed:32094113, ECO:0000269|PubMed:32814877, ECO:0000269|PubMed:36179027}.
uniprot
proteins
mass_dalton
62693
uniprot
proteins
mutagenesis
MUTAGEN 539; /note="W->R: Complete loss of E3 ligase activity."; /evidence="ECO:0000269|PubMed:31291587
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated; leads to proteasomal degradation. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20170641
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31291587
uniprot
proteins
pubmed
32094113
uniprot
proteins
pubmed
32814877
uniprot
proteins
pubmed
33964137
uniprot
proteins
pubmed
36179027
uniprot
proteins
sequence_length
566
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20170641}. Nucleus {ECO:0000269|PubMed:31291587}.
uniprot
proteins