Hand2
entrez
15111
canonical
uniprot
Q61039
canonical
ensembl
ENSMUSG00000038193
resolver
ensp
ENSMUSP00000044983
resolver
enst
ENSMUST00000040104
resolver
genesymbol
Hand2
resolver
genesymbol_syn
Dhand
resolver
genesymbol_syn
Hed
resolver
genesymbol_syn
Thing2
resolver
uniprot
Q61100
resolver
uniprot_entry
HAND2_MOUSE
resolver
uniprot_sec
Q61100
resolver
amino_acid_sequence
MSLVGGFPHHPVVHHEGYPFAAAAAAAAAAAASRCSHEENPYFHGWLIGHPEMSPPDYSMALSYSPEYASGAAGLDHSHYGGVPPGAGPPGLGGPRPVKRRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQNGEAEAFKAEIKKTDVKEEKRKKELNEILKSTVSSNDKKTKGRTGWPQHVWALELKQ
uniprot
proteins
function
FUNCTION: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. {ECO:0000269|PubMed:10769237, ECO:0000269|PubMed:10804186, ECO:0000269|PubMed:9171826, ECO:0000269|PubMed:9671575}.
uniprot
proteins
mass_dalton
23666
uniprot
proteins
pubmed
10769237
uniprot
proteins
pubmed
10804186
uniprot
proteins
pubmed
10924525
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
7671815
uniprot
proteins
pubmed
8533092
uniprot
proteins
pubmed
9171826
uniprot
proteins
pubmed
9671575
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
uniprot
proteins