ATP8B3
entrez
148229
canonical
uniprot
O60423
canonical
ensembl
ENSG00000130270
resolver
ensp
ENSP00000311336
resolver
ensp
ENSP00000437115
resolver
genesymbol
ATP8B3
resolver
genesymbol_syn
ATP1K
resolver
genesymbol_syn
FOS37502_2
resolver
hgnc
HGNC:13535
resolver
uniprot
Q7Z485
resolver
uniprot
Q8IVB8
resolver
uniprot
Q8N4Y8
resolver
uniprot
Q96M22
resolver
uniprot_entry
AT8B3_HUMAN
resolver
uniprot_sec
Q7Z485
resolver
uniprot_sec
Q8IVB8
resolver
uniprot_sec
Q8N4Y8
resolver
uniprot_sec
Q96M22
resolver
amino_acid_sequence
MGTGPAQTPRSTRAGPEPSPAPPGPGDTGDSDVTQEGSGPAGIRGGETVIRAGMGDSPGRGAPERRHKAQPGRARKYEWRPEGPTSMGSLGQREDLQDEDRNSAFTWKVQANNRAYNGQFKEKVILCWQRKKYKTNVIRTAKYNFYSFLPLNLYEQFHRVSNLFFLIIIILQSIPDISTLPWFSLSTPMVCLLFIRATRDLVDDMGRHKSDRAINNRPCQILMGKSFKQKKWQDLCVGDVVCLRKDNIVPADMLLLASTEPSSLCYVETVDIDGETNLKFRQALMVTHKELATIKKMASFQGTVTCEAPNSRMHHFVGCLEWNDKKYSLDIGNLLLRGCRIRNTDTCYGLVIYAGFDTKIMKNCGKIHLKRTKLDLLMNKLVVVIFISVVLVCLVLAFGFGFSVKEFKDHHYYLSGVHGSSVAAESFFVFWSFLILLSVTIPMSMFILSEFIYLGNSVFIDWDVQMYYKPQDVPAKARSTSLNDHLGQVEYIFSDKTGTLTQNILTFNKCCISGRVYGPDSEATTRPKENPYLWNKFADGKLLFHNAALLHLVRTNGDEAVREFWRLLAICHTVMVRESPRERPDQLLYQAASPDEGALVTAARNFGYVFLSRTQDTVTIMELGEERVYQVLAIMDFNSTRKRMSVLVRKPEGAICLYTKGADTVIFERLHRRGAMEFATEEALAAFAQETLRTLCLAYREVAEDIYEDWQQRHQEASLLLQNRAQALQQLLGATAIEDRLQDGVPETIKCLKKSNIKIWVLTGDKQETAVNIGFACELLSENMLILEEKEISRILETYWENSNNLLTRESLSQVKLALVINGDFLDKLLVSLRKEPRALAQNVNMDEAWQELGQSRRDFLYARRLSLLCRRFGLPLAAPPAQDSRARRSSEVLQERAFVDLASKCQAVICCRVTPKQKALIVALVKKYHQVVTLAIGDGANDINMIKTADVGVGLAGQEGMQAVQNSDFVLGQFCFLQRLLLVHGRWSYVRICKFLRYFFYKSMASMMVQVWFACYNGFTGQPLYEGWFLALFNLLYSTLPVLYIGLFEQDVSAEQSLEKPELYVVGQKDELFNYWVFVQAIAHGVTTSLVNFFMTLWISRDTAGPASFSDHQSFAVVVALSCLLSITMEVILIIKYWTALCVATILLSLGFYAIMTTTTQSFWLFRVSPTTFPFLYADLSVMSSPSILLVVLLSVSINTFPVLALRVIFPALKELRAKEEKVEEGPSEEIFTMEPLPHVHRESRARRSSYAFSHREGYANLITQGTILRRGPGVSSDIASESLDPSDEEAASSPKESQ
uniprot
proteins
ec_number
7.6.2.1
uniprot
proteins
function
FUNCTION: P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida. {ECO:0000250|UniProtKB:Q6UQ17}.
uniprot
proteins
mass_dalton
146752
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IV subfamily
uniprot
proteins
pubmed
12880872
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20947505
uniprot
proteins
sequence_length
1300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q6UQ17}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20947505}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 150..171; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 178..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 382..403; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 431..452; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 996..1016; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1029..1048; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1079..1100; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1113..1135; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1142..1162; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1183..1207; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins