PPP2R5C
entrez
5527
canonical
uniprot
Q13362
canonical
ensembl
ENSG00000078304
resolver
ensp
ENSP00000262239
resolver
ensp
ENSP00000329009
resolver
ensp
ENSP00000333905
resolver
ensp
ENSP00000408389
resolver
ensp
ENSP00000412324
resolver
ensp
ENSP00000511581
resolver
enst
ENST00000694906
resolver
genesymbol
PPP2R5C
resolver
genesymbol_syn
KIAA0044
resolver
hgnc
HGNC:9311
resolver
uniprot
A0A8Q3WKR3
resolver
uniprot
B4DYJ8
resolver
uniprot
B5BUA5
resolver
uniprot
F5GWP3
resolver
uniprot
Q14391
resolver
uniprot
Q15060
resolver
uniprot
Q15174
resolver
uniprot
Q6ZN33
resolver
uniprot_entry
2A5G_HUMAN
resolver
uniprot_entry
A0A8Q3WKR3_HUMAN
resolver
uniprot_sec
B4DYJ8
resolver
uniprot_sec
B5BUA5
resolver
uniprot_sec
F5GWP3
resolver
uniprot_sec
Q14391
resolver
uniprot_sec
Q15060
resolver
uniprot_sec
Q15174
resolver
uniprot_sec
Q6ZN33
resolver
amino_acid_sequence
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAHQAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR
uniprot
proteins
disease_involvement
DISEASE: Houge-Janssens syndrome 4 (HJS4) [MIM:621185]: An autosomal dominant neurodevelopmental disorder characterized by stable developmental delay, intellectual disability of variable degrees, poor or absent speech, generalized hypotonia, seizures, behavioral features, and abnormal coordination. Most affected individuals have a large head circumference or macrocephaly. Disease onset is in infancy or early childhood. {ECO:0000269|PubMed:25972378, ECO:0000269|PubMed:39978342}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. {ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:17245430}.
uniprot
proteins
mass_dalton
61061
uniprot
proteins
post_translational_modification
PTM: Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C. {ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:8703017}.
uniprot
proteins
protein_family
Phosphatase 2A regulatory subunit B56 family
uniprot
proteins
pubmed
10508479
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16456541
uniprot
proteins
pubmed
16541025
uniprot
proteins
pubmed
16580887
uniprot
proteins
pubmed
17086192
uniprot
proteins
pubmed
17174897
uniprot
proteins
pubmed
17245430
uniprot
proteins
pubmed
17967874
uniprot
proteins
pubmed
18618707
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
19716788
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25972378
uniprot
proteins
pubmed
28174209
uniprot
proteins
pubmed
30615140
uniprot
proteins
pubmed
39978342
uniprot
proteins
pubmed
7584044
uniprot
proteins
pubmed
7592815
uniprot
proteins
pubmed
8617797
uniprot
proteins
pubmed
8694763
uniprot
proteins
pubmed
8703017
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere.
uniprot
proteins