Igsf8
entrez
140559
canonical
uniprot
Q8R366
canonical
ensembl
ENSMUSG00000038034
resolver
ensp
ENSMUSP00000041232
resolver
ensp
ENSMUSP00000083076
resolver
enst
ENSMUST00000039506
resolver
enst
ENSMUST00000085912
resolver
genesymbol
Igsf8
resolver
genesymbol_syn
Ewi2
resolver
genesymbol_syn
Kct4
resolver
genesymbol_syn
Pgrl
resolver
uniprot
A0A0R4J117
resolver
uniprot
Q8R0L7
resolver
uniprot_entry
A0A0R4J117_MOUSE
resolver
uniprot_entry
IGSF8_MOUSE
resolver
uniprot_sec
Q8R0L7
resolver
amino_acid_sequence
MGVPSPTPLSSLLLLLLILGTRCYARQVHVPRGPLYRVAGTAVSISCNVSDYEGPAQQDFEWFMYRPEAPATSLGIVSTKDSQFSYAVFGPRVASGDLQVQRLKGDSVVLKIARLQAQDSGFYECYTPSTDTQYLGNYSAKVELRVLPDELQVSAAPPGPRGRQAATSPSRLTVHEGQELALGCLAQTKTKKHTHLSVSFGRAIPEAPVGRATLQEVVGLRSDMAVEAGAPYAERLASGELRLSKEGTDRYRMVVGGAQAGDSGTYHCTAAEWIQDPDGSWVQVAEKRAVLAHVDVQTLSSQLAVTVGPGERRIGPGEPLELLCNVSGALPPPGRHAAYSVGWEMAPAGAPGPGRLVAQLDTEGIGSLGPGYEDRHIAMEKVASRTYRLRLEAARPADAGTYRCLAKAYVRGSGTRLREAASARSRPLPVHVREEGVVLEAVAWLAGGTVYRGETASLLCNISVRGGPPGLRLAASWWVERPEEGELSSGPAQLVGGVGQDGVAELGVRPGGGPVSVELVGPRSHRLRLHGLGPEDEGIYHCAPSAWVQHADYSWYQAGSARSGPVTVYPYTHAVDTLFVPLLVGTGVALVTGASVLATITCCFMKRMRKR
uniprot
proteins
function
FUNCTION: Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity (PubMed:11673522). Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities. In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation. Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry. Accumulates at the presynaptic terminal, the producer cell side of the virological synapse, to prevent HIV-1 Env-mediated cell-cell fusion. Highly expressed on malignant cells with antigen presentation defects, interacts with NK receptor KLRA9 to suppress NK-cell cytotoxicity (PubMed:38657602). May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain (PubMed:16203089). {ECO:0000250|UniProtKB:Q969P0, ECO:0000269|PubMed:11673522, ECO:0000269|PubMed:16203089, ECO:0000269|PubMed:38657602}.
uniprot
proteins
mass_dalton
65011
uniprot
proteins
pubmed
11673522
uniprot
proteins
pubmed
12595239
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16203089
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21609323
uniprot
proteins
pubmed
22609062
uniprot
proteins
pubmed
23575678
uniprot
proteins
pubmed
38657602
uniprot
proteins
sequence_length
611
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21609323}; Single-pass membrane protein {ECO:0000269|PubMed:21609323}.
uniprot
proteins
transmembrane_region
TRANSMEM 578..598; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins