Nr1h2
entrez
58851
canonical
uniprot
Q62755
canonical
ensembl
ENSRNOG00000019812
resolver
ensembl
ENSRNOG00055005528
resolver
ensembl
ENSRNOG00060007205
resolver
ensembl
ENSRNOG00065027607
resolver
ensp
ENSRNOP00000026862
resolver
ensp
ENSRNOP00055006742
resolver
ensp
ENSRNOP00060008928
resolver
ensp
ENSRNOP00065039051
resolver
enst
ENSRNOT00000026862
resolver
enst
ENSRNOT00055008873
resolver
enst
ENSRNOT00060011864
resolver
enst
ENSRNOT00065047610
resolver
genesymbol
Nr1h2
resolver
genesymbol_syn
Lxrb
resolver
uniprot
A0A8L2QE94
resolver
uniprot
Q62694
resolver
uniprot_entry
A0A8L2QE94_RAT
resolver
uniprot_entry
NR1H2_RAT
resolver
uniprot_sec
Q62694
resolver
amino_acid_sequence
MSSPTSSLDTPLPGNGSPQPSTSSTSPTIKEEGQETDPPPGSEGSSSAYIVVILEPEDEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCKEAGMREQCVLSEEQIRKKKIQKQQQQQPPPPTEPASGSSARPAASPGTSEASSQGSGEGEGIQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
uniprot
proteins
function
FUNCTION: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (By similarity). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity). {ECO:0000250|UniProtKB:P55055, ECO:0000250|UniProtKB:Q60644}.
uniprot
proteins
mass_dalton
49736
uniprot
proteins
post_translational_modification
PTM: Sumoylated by SUMO2 at Lys-395 and Lys-433 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation. {ECO:0000250|UniProtKB:P55055}.
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
7892230
uniprot
proteins
pubmed
7971966
uniprot
proteins
sequence_length
446
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
uniprot
proteins