COMMD1
entrez
150684
canonical
uniprot
Q8N668
canonical
ensembl
ENSG00000173163
resolver
ensp
ENSP00000308236
resolver
ensp
ENSP00000788199
resolver
genesymbol
COMMD1
resolver
genesymbol_syn
C2orf5
resolver
genesymbol_syn
MURR1
resolver
hgnc
HGNC:23024
resolver
uniprot
B4DFQ4
resolver
uniprot
Q96GS0
resolver
uniprot_entry
COMD1_HUMAN
resolver
uniprot_sec
B4DFQ4
resolver
uniprot_sec
Q96GS0
resolver
amino_acid_sequence
MAAGELEGGKPLSGLLNALAQDTFHGYPGITEELLRSQLYPEVPPEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGGITSDQAAVISKFWKSHKTKIRESLMNQSRWNSGLRGLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQESEFLCLEFDEVKVNQILKTLSEVEESISTLISQPN
uniprot
proteins
function
FUNCTION: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). Can bind one copper ion per monomer (PubMed:17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:18940794). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:20458141). Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin-dependent manner (PubMed:28604741). {ECO:0000269|PubMed:14645214, ECO:0000269|PubMed:14685266, ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520, ECO:0000269|PubMed:17183367, ECO:0000269|PubMed:17309234, ECO:0000269|PubMed:20048074, ECO:0000269|PubMed:20237237, ECO:0000269|PubMed:20458141, ECO:0000269|PubMed:20595380, ECO:0000269|PubMed:21483833, ECO:0000269|PubMed:21741370, ECO:0000269|PubMed:21778237, ECO:0000269|PubMed:23515529, ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28604741, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129}.
uniprot
proteins
mass_dalton
21178
uniprot
proteins
mutagenesis
MUTAGEN 110; /note="M->A: Reduces copper-induced fluorescence change."; /evidence="ECO:0000269|PubMed:17309234"; MUTAGEN 134; /note="H->A: Reduces copper-induced fluorescence change."; /evidence="ECO:0000269|PubMed:17309234
uniprot
proteins
post_translational_modification
PTM: Acetylated by EP300 ina stimuli-specific manner; protecting it from XIAP-mediated proteasomal degradation and required for interaction with RElA in response to stress. {ECO:0000269|PubMed:25074812}.; PTM: Ubiquitinated; undergoes both 'Lys-63'- and 'Lys-48'-linked polyubiquitination. Ubiquitinated by XIAP, leading to its proteasomal degradation. {ECO:0000269|PubMed:14685266, ECO:0000269|PubMed:18305112, ECO:0000269|PubMed:20068069}.
uniprot
proteins
protein_family
COMM domain-containing protein 1 family
uniprot
proteins
pubmed
11809725
uniprot
proteins
pubmed
12547404
uniprot
proteins
pubmed
12968035
uniprot
proteins
pubmed
14645214
uniprot
proteins
pubmed
14685266
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15205742
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15799966
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16573520
uniprot
proteins
pubmed
17097678
uniprot
proteins
pubmed
17183367
uniprot
proteins
pubmed
17309234
uniprot
proteins
pubmed
17919502
uniprot
proteins
pubmed
18305112
uniprot
proteins
pubmed
18940794
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20048074
uniprot
proteins
pubmed
20068069
uniprot
proteins
pubmed
20237237
uniprot
proteins
pubmed
20458141
uniprot
proteins
pubmed
20595380
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21483833
uniprot
proteins
pubmed
21667063
uniprot
proteins
pubmed
21741370
uniprot
proteins
pubmed
21778237
uniprot
proteins
pubmed
23515529
uniprot
proteins
pubmed
23563313
uniprot
proteins
pubmed
23637203
uniprot
proteins
pubmed
25074812
uniprot
proteins
pubmed
25355947
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28604741
uniprot
proteins
pubmed
28892079
uniprot
proteins
pubmed
37172566
uniprot
proteins
pubmed
38459129
uniprot
proteins
pubmed
38504028
uniprot
proteins
sequence_length
190
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21778237, ECO:0000269|PubMed:28604741}. Cytoplasm {ECO:0000269|PubMed:21778237}. Endosome membrane {ECO:0000269|PubMed:18940794}. Cytoplasmic vesicle {ECO:0000269|PubMed:18940794}. Early endosome {ECO:0000269|PubMed:21483833, ECO:0000269|PubMed:25355947}. Recycling endosome {ECO:0000269|PubMed:21483833, ECO:0000269|PubMed:21741370}. Note=Shuttles between nucleus and cytosol. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins.
uniprot
proteins