Scaf8
entrez
106583
canonical
uniprot
Q6DID3
canonical
ensembl
ENSMUSG00000046201
resolver
ensp
ENSMUSP00000076024
resolver
enst
ENSMUST00000076734
resolver
genesymbol
Scaf8
resolver
genesymbol_syn
Kiaa1116
resolver
genesymbol_syn
Rbm16
resolver
uniprot
Q3TTX6
resolver
uniprot
Q5U5V8
resolver
uniprot
Q80TJ3
resolver
uniprot
Q8C037
resolver
uniprot
Q8C9D3
resolver
uniprot_entry
Q8C9D3_MOUSE
resolver
uniprot_entry
SCAF8_MOUSE
resolver
uniprot_sec
Q3TTX6
resolver
uniprot_sec
Q5U5V8
resolver
uniprot_sec
Q80TJ3
resolver
uniprot_sec
Q8C037
resolver
amino_acid_sequence
MEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLASTTAAMSNTPGTPVTPVTPANVVQGLPDPWVSQIANTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQLTAAAAAANTLTPLDQGVSFNKKLMDRFDFGEDSEHSEESKKEMPTPQLSHVSESVNNSIFHQIAEQLQQQNLEQLRQQLLEQQQPQKVTPQDSQEGTFGSEHSASPSQGSSQQHFLEPEANLDDSIDIQQQDMDIDEGQDVVEEEIFEPEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSHSREKKRKASRSYSSERRAREREKERQKKGLPPVRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYVCMVHRQDSFRALQKLSSGSYKIGSKVIKIAWALNKGVKTEYKQFWDVDLGVTYIPWEKVKVDDLDGFAEGGMIDQETVNAEWETVKASEPVKEPVQTAQSPAPVEKESVVTTQAEVFPPPVAMLQIPVAPAVPAVSLVPPAFPVSMPVPPPGFNPIPPPPFLRASFNPSQPPPGFMPPPVPPPVVPPPAIPPVVPTSLVQPPLSMTPEAVKDVGFGSLVLPSGSVAGSLAPSTLPAGNVFNPPSKAEPEEKVPHLIEHQIPSGENTRPVIPSDIPSSAAMLAQPPGASSTSGILCVQRPNVSSNSEILGVRPANVSNSAAIMGAQPPNILNNSGILAIQPPNVSSGSGLLGVLPPNLPNNSGLVGLQPPNVTSPAGLLGTQPPIGPQNLPPLAIPAQRMPALPMLDIRPGLIAQAPGPRFPLLQPGIPPQRGIPPPSVLDAALHPPPRGPFPPGDLFSQPERPFLAPGRPSIDNVPNPDKRIPLGNDNIQQEGDRDYRFPPIETREGITRPPQVDVRDVVGRRLDPREGPGRPPLDARDHFGRPPVDMRENLVRPSLDHLGRRDHFGFPPEKPWGPRDFDEREHRVLPVFGGPKGLHEERGRFRAGNYRFDPRSGPWNRGFGQEVHRDFDDRRRPWERQRDRDDRDFDFCREINGNRLGRDRIQNTWVPPPHARVFDYFEGATSQRKGDNVPQVNGENTERHAQPPPLPVQKDPELYEKLASSGDVDKEESGTVAGVESEAVVESTETEGT
uniprot
proteins
function
FUNCTION: Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation. {ECO:0000250|UniProtKB:Q9UPN6}.
uniprot
proteins
mass_dalton
139572
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
8692929
uniprot
proteins
pubmed
9528809
uniprot
proteins
sequence_length
1268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9528809}. Nucleus matrix {ECO:0000269|PubMed:9528809}. Note=Detected in granular nuclear foci which correspond to sites of active transcription. {ECO:0000250|UniProtKB:Q9UPN6}.
uniprot
proteins