BST1
entrez
683
canonical
uniprot
Q10588
canonical
ensembl
ENSG00000109743
resolver
ensp
ENSP00000265016
resolver
ensp
ENSP00000520950
resolver
ensp
ENSP00000614818
resolver
ensp
ENSP00000652842
resolver
ensp
ENSP00000691410
resolver
ensp
ENSP00000795151
resolver
ensp
ENSP00000795152
resolver
enst
ENST00000850863
resolver
genesymbol
BST1
resolver
hgnc
HGNC:1118
resolver
uniprot
A0ABJ7H2Z9
resolver
uniprot
B2R6A2
resolver
uniprot
Q1XII0
resolver
uniprot
Q5U0K0
resolver
uniprot
Q96EN3
resolver
uniprot_entry
A0ABJ7H2Z9_HUMAN
resolver
uniprot_entry
BST1_HUMAN
resolver
uniprot_sec
B2R6A2
resolver
uniprot_sec
Q1XII0
resolver
uniprot_sec
Q5U0K0
resolver
uniprot_sec
Q96EN3
resolver
activity_regulation
ACTIVITY REGULATION: ADP-ribosyl cyclase and cADPR hydrolase activities are both activated by Zn(2+) or Mn(2+), and inhibited by Cu(2+), while Mg(2+) and Ca(2+) do not have any significant influence. {ECO:0000269|PubMed:7805847}.
uniprot
proteins
amino_acid_sequence
MAAQGCAASRLLQLLLQLLLLLLLLAAGGARARWRGEGTSAHLRDIFLGRCAEYRALLSPEQRNKNCTAIWEAFKVALDKDPCSVLPSDYDLFINLSRHSIPRDKSLFWENSHLLVNSFADNTRRFMPLSDVLYGRVADFLSWCRQKNDSGLDYQSCPTSEDCENNPVDSFWKRASIQYSKDSSGVIHVMLNGSEPTGAYPIKGFFADYEIPNLQKEKITRIEIWVMHEIGGPNVESCGEGSMKVLEKRLKDMGFQYSCINDYRPVKLLQCVDHSTHPDCALKSAAAATQRKAPSLYTEQRAGLIIPLFLVLASRTQL
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR) (PubMed:7805847). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium (Probable). May be involved in pre-B-cell growth (Probable). {ECO:0000269|PubMed:7805847, ECO:0000305|PubMed:11866528, ECO:0000305|PubMed:7805847, ECO:0000305|PubMed:8202488}.
uniprot
proteins
mass_dalton
35724
uniprot
proteins
protein_family
ADP-ribosyl cyclase family
uniprot
proteins
pubmed
11866528
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7805847
uniprot
proteins
pubmed
8202488
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:8202488}.
uniprot
proteins