Elavl4
entrez
15572
canonical
uniprot
Q61701
canonical
ensembl
ENSMUSG00000028546
resolver
ensp
ENSMUSP00000099783
resolver
ensp
ENSMUSP00000099784
resolver
ensp
ENSMUSP00000102207
resolver
ensp
ENSMUSP00000102208
resolver
ensp
ENSMUSP00000102210
resolver
ensp
ENSMUSP00000102212
resolver
ensp
ENSMUSP00000102214
resolver
ensp
ENSMUSP00000235270
resolver
ensp
ENSMUSP00000235271
resolver
genesymbol
Elavl4
resolver
genesymbol_syn
Hud
resolver
uniprot
A2A9R6
resolver
uniprot
A2A9R7
resolver
uniprot
A2A9R8
resolver
uniprot
A2A9S0
resolver
uniprot
A2A9S1
resolver
uniprot
A2A9S2
resolver
uniprot
A2A9S3
resolver
uniprot
O55010
resolver
uniprot
Q6PHZ3
resolver
uniprot
Q80XH9
resolver
uniprot
Q8BVA9
resolver
uniprot
Q9CXQ0
resolver
uniprot_entry
ELAV4_MOUSE
resolver
uniprot_entry
Q80XH9_MOUSE
resolver
uniprot_entry
Q9CXQ0_MOUSE
resolver
uniprot_sec
A2A9R6
resolver
uniprot_sec
A2A9R7
resolver
uniprot_sec
A2A9R8
resolver
uniprot_sec
A2A9S0
resolver
uniprot_sec
A2A9S1
resolver
uniprot_sec
A2A9S2
resolver
uniprot_sec
A2A9S3
resolver
uniprot_sec
O55010
resolver
uniprot_sec
Q6PHZ3
resolver
uniprot_sec
Q8BVA9
resolver
amino_acid_sequence
MEWNGLKMIISTMEPQVSNGPTSNTSNGPSSNNRNCPSPMQTGAATDDSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKSSQALLSQLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRLMSGPVPPSACPPRFSPITIDGMTSLVGMNIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAHKS
uniprot
proteins
function
FUNCTION: RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:15764704, PubMed:16554442, PubMed:17035636, PubMed:20064466, PubMed:22387028, PubMed:23383270, PubMed:26305964, PubMed:28111162). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:15764704, PubMed:23383270, PubMed:26305964, PubMed:28111162). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (3'UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (By similarity). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (PubMed:26305964). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (By similarity). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed:20064466). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:15764704, PubMed:16554442, PubMed:18218628, PubMed:23383270, PubMed:24599466, PubMed:25692578, PubMed:26305964, PubMed:28111162). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (PubMed:15764704). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (PubMed:26305964). Binds and stabilizes MSI1 mRNA in neural stem cells (PubMed:16554442). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (By similarity). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (By similarity). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (PubMed:24599466). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:28111162). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (PubMed:23383270, PubMed:25692578). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (PubMed:28111162). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed:18218628). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (PubMed:20064466). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (PubMed:22387028). Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (PubMed:22387028). Also plays a role in the regulation of alternative splicing (PubMed:17035636). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich sequences of CALCA pre-mRNA (PubMed:17035636). {ECO:0000250|UniProtKB:O09032, ECO:0000250|UniProtKB:P26378, ECO:0000269|PubMed:15764704, ECO:0000269|PubMed:16554442, ECO:0000269|PubMed:17035636, ECO:0000269|PubMed:18218628, ECO:0000269|PubMed:20064466, ECO:0000269|PubMed:22387028, ECO:0000269|PubMed:23383270, ECO:0000269|PubMed:24599466, ECO:0000269|PubMed:25692578, ECO:0000269|PubMed:26305964, ECO:0000269|PubMed:28111162}.
uniprot
proteins
mass_dalton
42368
uniprot
proteins
mutagenesis
MUTAGEN 1..215; /note="Missing: Reduced association with polysomes and reduced stimulation of translation."; /evidence="ECO:0000269|PubMed:20064466"; MUTAGEN 149; /note="T->A: Decreased dendritic localization and decreased translation of reporter mRNA, when associated with Ala-165."; /evidence="ECO:0000269|PubMed:25692578"; MUTAGEN 165; /note="T->A: Decreased dendritic localization and decreased translation of reporter mRNA, when associated with Ala-149."; /evidence="ECO:0000269|PubMed:25692578"; MUTAGEN 277; /note="R->A: No impact on interaction with EIF4A."; /evidence="ECO:0000269|PubMed:20064466"; MUTAGEN 278; /note="F->A: Disrupts interaction with EIF4A and fails to stimulate translation."; /evidence="ECO:0000269|PubMed:20064466"; MUTAGEN 279; /note="S->A: No impact on interaction with EIF4A."; /evidence="ECO:0000269|PubMed:20064466"; MUTAGEN 280; /note="P->A: No impact on interaction with EIF4A."; /evidence="ECO:0000269|PubMed:20064466"; MUTAGEN 303..385; /note="Missing: Loss of association with polysomes and loss of translation stimulation."; /evidence="ECO:0000269|PubMed:20064466
uniprot
proteins
post_translational_modification
PTM: Methylated by CARM1, which leads to reduced RNA-binding activity and enhanced interaction with SMN (By similarity). Methylation at Arg-248 by CARM1 weakens protective binding to the 3'UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state (By similarity). Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:O09032, ECO:0000250|UniProtKB:P26378}.
uniprot
proteins
protein_family
RRM elav family
uniprot
proteins
pubmed
11573004
uniprot
proteins
pubmed
15086518
uniprot
proteins
pubmed
15519747
uniprot
proteins
pubmed
15764704
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16554442
uniprot
proteins
pubmed
17035636
uniprot
proteins
pubmed
18218628
uniprot
proteins
pubmed
18493953
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20064466
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21288476
uniprot
proteins
pubmed
21389246
uniprot
proteins
pubmed
22387028
uniprot
proteins
pubmed
22895702
uniprot
proteins
pubmed
23383270
uniprot
proteins
pubmed
24599466
uniprot
proteins
pubmed
24857657
uniprot
proteins
pubmed
25692578
uniprot
proteins
pubmed
26305964
uniprot
proteins
pubmed
28111162
uniprot
proteins
pubmed
8535975
uniprot
proteins
pubmed
9096138
uniprot
proteins
pubmed
9524251
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16554442, ECO:0000269|PubMed:21288476, ECO:0000269|PubMed:22387028}. Perikaryon {ECO:0000269|PubMed:21389246}. Cell projection, dendrite {ECO:0000269|PubMed:25692578}. Cell projection, axon {ECO:0000269|PubMed:21389246}. Cell projection, growth cone {ECO:0000269|PubMed:21389246}. Note=Co-localizes with ribosomal RNA in polysomes. {ECO:0000250|UniProtKB:O09032}.
uniprot
proteins