PYDC2
entrez
152138
canonical
uniprot
Q56P42
canonical
ensembl
ENSG00000253548
resolver
ensp
ENSP00000492367
resolver
enst
ENST00000518817
resolver
genesymbol
PYDC2
resolver
genesymbol_syn
POP2
resolver
hgnc
HGNC:33512
resolver
uniprot_entry
PYDC2_HUMAN
resolver
amino_acid_sequence
MASSAELDFNLQALLEQLSQDELSKFKSLIRTISLGKELQTVPQTEVDKANGKQLVEIFTSHSCSYWAGMAAIQVFEKMNQTHLSGRADEHCVMPPP
uniprot
proteins
function
FUNCTION: May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome (PubMed:17178784, PubMed:17339483). May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA (PubMed:17339483, PubMed:24871464). {ECO:0000269|PubMed:17178784, ECO:0000269|PubMed:17339483, ECO:0000269|PubMed:24871464}.
uniprot
proteins
mass_dalton
10795
uniprot
proteins
pubmed
17178784
uniprot
proteins
pubmed
17339483
uniprot
proteins
pubmed
21362197
uniprot
proteins
pubmed
24871464
uniprot
proteins
sequence_length
97
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17178784, ECO:0000269|PubMed:17339483}. Nucleus {ECO:0000269|PubMed:17178784, ECO:0000269|PubMed:17339483}. Note=Recruited to specks formed by PYCARD within the cytoplasm. {ECO:0000269|PubMed:17178784}.
uniprot
proteins