Plaa
entrez
18786
canonical
uniprot
P27612
canonical
ensembl
ENSMUSG00000028577
resolver
ensp
ENSMUSP00000102724
resolver
ensp
ENSMUSP00000191100
resolver
ensp
ENSMUSP00000191103
resolver
ensp
ENSMUSP00000191120
resolver
enst
ENSMUST00000107107
resolver
genesymbol
Plaa
resolver
genesymbol_syn
Plap
resolver
uniprot
A4QPD6
resolver
uniprot
Q8C6C4
resolver
uniprot_entry
PLAP_MOUSE
resolver
uniprot_sec
A4QPD6
resolver
uniprot_sec
Q8C6C4
resolver
amino_acid_sequence
MASGASRYRLSCSLPGHELDVRGLVCCLYPPGAFVSVSRDRTTRLWAPDSPNRGFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKDTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTIKLWKAGRCERTFLGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYFGHTNYIYSISVFPNSKDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLENGDIVVGASDGIIRVFTESEERTASAEEIKAFERELSQATIDSKTGDLGDINAEQLPGREHLSEPGTREGQTRLIRDGERVEAYQWSVSDGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNVSDDPWLVAYNFLQKNDLNPMFLDQVAKFIIDNTKGQTLGLGNTSFSDPFTGGGRYVPGTSGPSNTVQTADPFTGAGRYMPGSAGMDTTMTGVDPFTGNSAYRSAASKTVNIYFPKKEALTFDQANPTQILGKLKELNGTAPEEKKLTEDDLVLLEKILSLICNNSSEKPTAQQLQILWKAINWPEDIVFPALDILRLSIKHPNVNENFCNEKGDQFSSHLINLLNPKGKPANQLLALRTFCNCFVSQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLTLNYSVCFHKDHNIEGKAQCLSVISTILEVVQDLEATFRLLVALGTLISDDSNAIQLAKSLGVDSQIKKYVSVSEPAKVSECCRLVLHLL
uniprot
proteins
function
FUNCTION: Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (By similarity). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (PubMed:28413018). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (By similarity). Plays a role in cerebellar Purkinje cell development (PubMed:28413018). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:28007986). {ECO:0000250|UniProtKB:Q9Y263, ECO:0000269|PubMed:28007986, ECO:0000269|PubMed:28413018}.
uniprot
proteins
mass_dalton
87221
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="G->V: Loss of protein abundance. Increased abundance of ubiquitinated synaptic proteins. Decreased ubiquitin-mediated trafficking of membrane proteins through the endolysosomal pathway. Decreased synaptic vesicle recycling. Decreased cerebellar Purkinje cell migration and dendrite extension."; /evidence="ECO:0000269|PubMed:28413018
uniprot
proteins
protein_family
WD repeat PLAP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
2052621
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
28007986
uniprot
proteins
pubmed
28413018
uniprot
proteins
pubmed
7665086
uniprot
proteins
sequence_length
794
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28413018}. Cytoplasm {ECO:0000269|PubMed:28413018}. Synapse {ECO:0000269|PubMed:28413018}. Note=Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. {ECO:0000250|UniProtKB:Q9Y263}.
uniprot
proteins