NECTIN2
entrez
5819
canonical
uniprot
Q92692
canonical
ensembl
ENSG00000130202
resolver
ensp
ENSP00000252483
resolver
ensp
ENSP00000252485
resolver
ensp
ENSP00000796962
resolver
genesymbol
NECTIN2
resolver
genesymbol_syn
HVEB
resolver
genesymbol_syn
PRR2
resolver
genesymbol_syn
PVRL2
resolver
hgnc
HGNC:9707
resolver
uniprot
A8K5L5
resolver
uniprot
O75455
resolver
uniprot
Q6IBI6
resolver
uniprot
Q96J29
resolver
uniprot_entry
NECT2_HUMAN
resolver
uniprot_sec
A8K5L5
resolver
uniprot_sec
O75455
resolver
uniprot_sec
Q6IBI6
resolver
uniprot_sec
Q96J29
resolver
amino_acid_sequence
MARAAALLPSRSPPTPLLWPLLLLLLLETGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAVAATGILICRQQRKEQTLQGAEEDEDLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERSGPLHPGATSLGSPIPVPPGPPAVEDVSLDLEDEEGEEEEEYLDKINPIYDALSYSSPSDSYQGKGFVMSRAMYV
uniprot
proteins
function
FUNCTION: Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:9657005}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). {ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:9657005}.
uniprot
proteins
mass_dalton
57742
uniprot
proteins
mutagenesis
MUTAGEN 81; /note="N->A: Abolishes homodimerization."; /evidence="ECO:0000269|PubMed:22927415"; MUTAGEN 89; /note="M->F: Loss of entry of HHV-1/Rid1 and HSV-2. No effect on PRV entry."; /evidence="ECO:0000269|PubMed:11602758"; MUTAGEN 89; /note="M->I: Increased entry of HHV-1/Rid1 and HSV-2."; /evidence="ECO:0000269|PubMed:11602758
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
10520737
uniprot
proteins
pubmed
11602758
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15607800
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
19011627
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22927415
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26755705
uniprot
proteins
pubmed
7622062
uniprot
proteins
pubmed
9657005
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 361..381; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins