Slc12a4
entrez
29501
canonical
uniprot
Q63632
canonical
ensembl
ENSRNOG00000019651
resolver
ensembl
ENSRNOG00055018092
resolver
ensembl
ENSRNOG00060012273
resolver
ensembl
ENSRNOG00065012060
resolver
ensp
ENSRNOP00000026730
resolver
ensp
ENSRNOP00000078286
resolver
ensp
ENSRNOP00055024783
resolver
ensp
ENSRNOP00060016475
resolver
ensp
ENSRNOP00065015098
resolver
enst
ENSRNOT00000026730
resolver
enst
ENSRNOT00000095105
resolver
enst
ENSRNOT00055030794
resolver
enst
ENSRNOT00060020900
resolver
enst
ENSRNOT00065019700
resolver
genesymbol
Slc12a4
resolver
genesymbol_syn
Kcc1
resolver
uniprot
A0A8I5ZKL7
resolver
uniprot
P70632
resolver
uniprot_entry
A0A8I5ZKL7_RAT
resolver
uniprot_entry
S12A4_RAT
resolver
uniprot_sec
P70632
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by WNK3. {ECO:0000250|UniProtKB:Q9UP95}.
uniprot
proteins
amino_acid_sequence
MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAEREDSDGQGNHRENSPFLSPLDASRGNDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGGRRRAAKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGTHDMSSATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYVGGIKSAFDPPVFPVCMLGNRTLSRDQFDICAKTVVVDNETVATRLWTFFCHSPNLTADSCDPYFLLNNVTEIPGIPGAAAGVLQENLWSAYLEKGEVVEKHGLPSTDTLGLKESLSLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIVTTSLVYFSSVILFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVVGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKANGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWKKCRMRIFTVAQMDDNSIQMKKDLAIFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTERDREAQLVKDRHSALRLESLYSDEEDESVTGADKIQMTWTRDKYMAEPWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPKNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
uniprot
proteins
function
FUNCTION: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10347194). May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (Probable). {ECO:0000269|PubMed:10347194, ECO:0000305}.
uniprot
proteins
mass_dalton
120628
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10564083}.; PTM: Phosphorylated, phosphorylation may regulate transporter activity. {ECO:0000250|UniProtKB:Q9UP95}.
uniprot
proteins
protein_family
K/Cl co-transporter subfamily
uniprot
proteins
protein_family
SLC12A transporter family
uniprot
proteins
pubmed
10347194
uniprot
proteins
pubmed
10564083
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8663127
uniprot
proteins
sequence_length
1085
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q28677}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 120..141; /note="Discontinuously helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 150..172; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 197..225; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 249..271; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 272..297; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 420..440; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 451..473; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 505..531; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 555..575; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 576..598; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 613..635; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 636..651; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q9UP95
uniprot
proteins