Oasl2
entrez
23962
canonical
uniprot
Q9Z2F2
canonical
ensembl
ENSMUSG00000029561
resolver
ensp
ENSMUSP00000031542
resolver
enst
ENSMUST00000031542
resolver
genesymbol
Oasl2
resolver
uniprot
Q9D6S2
resolver
uniprot_entry
OASL2_MOUSE
resolver
uniprot_sec
Q9D6S2
resolver
activity_regulation
ACTIVITY REGULATION: Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group is tolerated. ssRNA or dsDNA do not act as activators. {ECO:0000269|PubMed:12799444}.
uniprot
proteins
amino_acid_sequence
MDPFPDLYATPGDSLDHFLEHSLQPQRDWKEEGQDAWERIERFFREQCFRDELLLDQEVRVIKVVKGGSSGKGTTLNHRSDQDMILFLSCFSSFEEQARNREVVISFIKKRLIHCSRSLAYNIIVLTHREGKRAPRSLTLKVQSRKTDDIIWMDILPAYDALGPISRDSKPAPAIYETLIRSKGYPGDFSPSFTELQRHFVKTRPVKLKNLLRLVKFWYLQCLRRKYGRGAVLPSKYALELLTIYAWEMGTESSDSFNLDEGFVAVMELLVNYRDICIYWTKYYNFQNEVVRNFLKKQLKGDRPIILDPADPTNNLGRRKGWEQVAAEAAFCLLQVCCTTVGPSERWNVQRARDVQVRVKQTGTVDWTLWTNPYSPIRKMKAEIRREKNFGGELRISFQEPGGERQLLSSRKTLADYGIFSKVNIQVLETFPPEILVFVKYPGGQSKPFTIDPDDTILDLKEKIEDAGGPCAEDQVLLLDDEELEDDESLKELEIKDCDTIILIRVID
uniprot
proteins
ec_number
2.7.7.84
uniprot
proteins
function
FUNCTION: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Catalyzes the formation of 2'-5'-oligoadenylates (2-5A) from polymerization of ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:12396720, ECO:0000269|PubMed:12799444}.
uniprot
proteins
mass_dalton
58767
uniprot
proteins
protein_family
2-5A synthase family
uniprot
proteins
pubmed
10395668
uniprot
proteins
pubmed
12396720
uniprot
proteins
pubmed
12799444
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17024523
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
508
uniprot
proteins