HS3ST6
entrez
64711
canonical
uniprot
Q96QI5
canonical
ensembl
ENSG00000162040
resolver
ensembl
ENSG00000276333
resolver
ensp
ENSP00000293937
resolver
ensp
ENSP00000416741
resolver
enst
ENST00000293937
resolver
enst
ENST00000454677
resolver
genesymbol
HS3ST6
resolver
genesymbol_syn
HS3ST5
resolver
hgnc
HGNC:14178
resolver
uniprot
Q96RX7
resolver
uniprot_entry
HS3S6_HUMAN
resolver
uniprot_sec
Q96RX7
resolver
amino_acid_sequence
MAGSGGLGGGAGGGQGAGAGQGAALRASRAPMLLVALVLGAYCLCALPGRCPPAARAPAPAPAPSEPSSSVHRPGAPGLPLASGPGRRRFPQALIVGVKKGGTRALLEFLRLHPDVRALGSEPHFFDRCYERGLAWYRSLMPRTLDGQITMEKTPSYFVTREAPRRIHAMSPDTKLIVVVRNPVTRAISDYAQTLSKTPGLPSFRALAFRHGLGPVDTAWSAVRIGLYAQHLDHWLRYFPLSHFLFVSGERLVSDPAGEVGRVQDFLGLKRVVTDKHFYFNATKGFPCLKKAQGGSRPRCLGKSKGRPHPRVPQALVRRLQEFYRPFNRRFYQMTGQDFGWG
uniprot
proteins
disease_involvement
DISEASE: Angioedema, hereditary, 8 (HAE8) [MIM:619367]: A form of angioedema, a disorder characterized by episodic local swelling involving subcutaneous or submucous tissue of the upper respiratory and gastrointestinal tracts, face, extremities, and genitalia. HAE8 inheritance is autosomal dominant. {ECO:0000269|PubMed:33508266}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.8.2.23
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. {ECO:0000250|UniProtKB:Q5GFD5}.; FUNCTION: (Microbial infection) Acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. {ECO:0000269|PubMed:15303968}.
uniprot
proteins
mass_dalton
37186
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
11157797
uniprot
proteins
pubmed
15303968
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
33508266
uniprot
proteins
sequence_length
342
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..49; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins