GPRC6A
entrez
222545
canonical
uniprot
Q5T6X5
canonical
ensembl
ENSG00000173612
resolver
ensp
ENSP00000309493
resolver
ensp
ENSP00000357537
resolver
ensp
ENSP00000433465
resolver
genesymbol
GPRC6A
resolver
hgnc
HGNC:18510
resolver
uniprot
Q6JK43
resolver
uniprot
Q6JK44
resolver
uniprot
Q8NGU8
resolver
uniprot
Q8NHZ9
resolver
uniprot
Q8TDT6
resolver
uniprot_entry
GPC6A_HUMAN
resolver
uniprot_sec
Q6JK43
resolver
uniprot_sec
Q6JK44
resolver
uniprot_sec
Q8NGU8
resolver
uniprot_sec
Q8NHZ9
resolver
uniprot_sec
Q8TDT6
resolver
amino_acid_sequence
MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHSIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWIASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQAQAFAHICRENATSVSKTLPRKRMSSI
uniprot
proteins
function
FUNCTION: Receptor activated by multiple ligands, including osteocalcin (BGLAP), basic amino acids, and various cations (PubMed:15576628). Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids (PubMed:15576628). The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+) (By similarity). Seems to act through a G(q)/G(11) and G(i)-coupled pathway (By similarity). Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (By similarity). Mediates the non-genomic effects of androgens in multiple tissue (By similarity). May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (PubMed:20947496). {ECO:0000250|UniProtKB:Q8K4Z6, ECO:0000269|PubMed:15576628, ECO:0000269|PubMed:20947496}.
uniprot
proteins
mass_dalton
104753
uniprot
proteins
mutagenesis
MUTAGEN 149; /note="S->A: Loss of function."; /evidence="ECO:0000269|PubMed:15576628"; MUTAGEN 172; /note="T->A: Loss of function."; /evidence="ECO:0000269|PubMed:15576628
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
pubmed
12044878
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15194188
uniprot
proteins
pubmed
15576628
uniprot
proteins
pubmed
20947496
uniprot
proteins
pubmed
25617829
uniprot
proteins
sequence_length
926
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8K4Z6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K4Z6}.
uniprot
proteins
transmembrane_region
TRANSMEM 595..615; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 632..652; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 670..690; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 705..725; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 749..769; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 783..803; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 811..831; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins