PRMT7
entrez
54496
canonical
uniprot
Q9NVM4
canonical
ensembl
ENSG00000132600
resolver
ensp
ENSP00000343103
resolver
ensp
ENSP00000409324
resolver
ensp
ENSP00000414716
resolver
ensp
ENSP00000454776
resolver
ensp
ENSP00000457381
resolver
ensp
ENSP00000508937
resolver
ensp
ENSP00000509008
resolver
ensp
ENSP00000509231
resolver
ensp
ENSP00000509523
resolver
ensp
ENSP00000509677
resolver
ensp
ENSP00000510167
resolver
ensp
ENSP00000510428
resolver
ensp
ENSP00000510574
resolver
ensp
ENSP00000510630
resolver
ensp
ENSP00000510669
resolver
ensp
ENSP00000510738
resolver
ensp
ENSP00000567175
resolver
ensp
ENSP00000597030
resolver
ensp
ENSP00000597032
resolver
ensp
ENSP00000597033
resolver
ensp
ENSP00000597034
resolver
ensp
ENSP00000597037
resolver
ensp
ENSP00000597039
resolver
ensp
ENSP00000620227
resolver
ensp
ENSP00000620230
resolver
ensp
ENSP00000720705
resolver
ensp
ENSP00000720706
resolver
ensp
ENSP00000720707
resolver
enst
ENST00000562050
resolver
enst
ENST00000568975
resolver
enst
ENST00000685109
resolver
enst
ENST00000686904
resolver
enst
ENST00000687654
resolver
enst
ENST00000689486
resolver
enst
ENST00000690932
resolver
enst
ENST00000691961
resolver
enst
ENST00000692621
resolver
enst
ENST00000692632
resolver
enst
ENST00000692966
resolver
enst
ENST00000693200
resolver
enst
ENST00000897116
resolver
enst
ENST00000926971
resolver
enst
ENST00000926978
resolver
enst
ENST00000926980
resolver
enst
ENST00000950171
resolver
genesymbol
PRMT7
resolver
genesymbol_syn
KIAA1933
resolver
hgnc
HGNC:25557
resolver
uniprot
A0A8I5KPP4
resolver
uniprot
A0A8I5KXS9
resolver
uniprot
A0A8I5KYD6
resolver
uniprot
A0A8I5KZ05
resolver
uniprot
A0A8I5KZ92
resolver
uniprot
B3KPR0
resolver
uniprot
B3KUG9
resolver
uniprot
B4E379
resolver
uniprot
H3BNC0
resolver
uniprot
H3BTY1
resolver
uniprot
Q96PV5
resolver
uniprot
Q9H9L0
resolver
uniprot_entry
A0A8I5KPP4_HUMAN
resolver
uniprot_entry
A0A8I5KXS9_HUMAN
resolver
uniprot_entry
A0A8I5KYD6_HUMAN
resolver
uniprot_entry
A0A8I5KZ05_HUMAN
resolver
uniprot_entry
A0A8I5KZ92_HUMAN
resolver
uniprot_entry
ANM7_HUMAN
resolver
uniprot_entry
H3BNC0_HUMAN
resolver
uniprot_sec
B3KPR0
resolver
uniprot_sec
B3KUG9
resolver
uniprot_sec
B4E379
resolver
uniprot_sec
H3BTY1
resolver
uniprot_sec
Q96PV5
resolver
uniprot_sec
Q9H9L0
resolver
amino_acid_sequence
MKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRNVKYYQGIRAAVSRVKDRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVINKHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPSYEHAHRHLVEENCEAVPHRATVYAQLVESGRMWSWNKLFPIHVQTSLGEQVIVPPVDVESCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAPFWAHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALYLVAHHDDYCVWYSLQRTSPEKNERVRQMRPVCDCQAHLLWNRPRFGEINDQDRTDRYVQALRTVLKPDSVCLCVSDGSLLSVLAHHLGVEQVFTVESSAASHKLLRKIFKANHLEDKINIIEKRPELLTNEDLQGRKVSLLLGEPFFTTSLLPWHNLYFWYVRTAVDQHLGPGAMVMPQAASLHAVVVEFRDLWRIRSPCGDCEGFDVHIMDDMIKRALDFRESREAEPHPLWEYPCRSLSEPWQILTFDFQQPVPLQPLCAEGTVELRRPGQSHAAVLWMEYHLTPECTLSTGLLEPADPEGGCCWNPHCKQAVYFFSPAPDPRALLGGPRTVSYAVEFHPDTGDIIMEFRHADTPD
uniprot
proteins
disease_involvement
DISEASE: Short stature, brachydactyly, impaired intellectual developmental, and seizures (SBIDDS) [MIM:617157]: An autosomal recessive disease characterized by developmental delay, learning disabilities, mild intellectual disability, delayed speech, and skeletal abnormalities. Skeletal features include short stature, brachydactyly, and short metacarpals and metatarsals. {ECO:0000269|PubMed:26437029}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.1.1.321
uniprot
proteins
function
FUNCTION: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. {ECO:0000269|PubMed:15044439, ECO:0000269|PubMed:15494416, ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19110445}.
uniprot
proteins
mass_dalton
78459
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
PRMT7 subfamily
uniprot
proteins
protein_family
Protein arginine N-methyltransferase family
uniprot
proteins
pubmed
11572484
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15044439
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15494416
uniprot
proteins
pubmed
17709427
uniprot
proteins
pubmed
18381071
uniprot
proteins
pubmed
19089452
uniprot
proteins
pubmed
19110445
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25294873
uniprot
proteins
pubmed
26437029
uniprot
proteins
sequence_length
692
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15494416}. Nucleus {ECO:0000269|PubMed:15494416}.
uniprot
proteins