Tec
entrez
21682
canonical
uniprot
P24604
canonical
ensembl
ENSMUSG00000029217
resolver
ensp
ENSMUSP00000071836
resolver
ensp
ENSMUSP00000073509
resolver
ensp
ENSMUSP00000109224
resolver
ensp
ENSMUSP00000230173
resolver
ensp
ENSMUSP00000230176
resolver
ensp
ENSMUSP00000230178
resolver
ensp
ENSMUSP00000230184
resolver
enst
ENSMUST00000071944
resolver
enst
ENSMUST00000073843
resolver
enst
ENSMUST00000113594
resolver
genesymbol
Tec
resolver
uniprot
F6VUV8
resolver
uniprot
F7AKZ9
resolver
uniprot
I6L9F0
resolver
uniprot
Q3TH41
resolver
uniprot
Q3U436
resolver
uniprot
Q8CFK4
resolver
uniprot
Q9R1M9
resolver
uniprot
Q9WVN0
resolver
uniprot
Q9WVN1
resolver
uniprot
Q9WVN2
resolver
uniprot
Q9WVN3
resolver
uniprot_entry
F6VUV8_MOUSE
resolver
uniprot_entry
F7AKZ9_MOUSE
resolver
uniprot_entry
I6L9F0_MOUSE
resolver
uniprot_entry
Q3TH41_MOUSE
resolver
uniprot_entry
Q3U436_MOUSE
resolver
uniprot_entry
Q8CFK4_MOUSE
resolver
uniprot_entry
TEC_MOUSE
resolver
uniprot_sec
Q9R1M9
resolver
uniprot_sec
Q9WVN0
resolver
uniprot_sec
Q9WVN1
resolver
uniprot_sec
Q9WVN2
resolver
uniprot_sec
Q9WVN3
resolver
activity_regulation
ACTIVITY REGULATION: Activated by tyrosine phosphorylation by a wide range of cytokine stimulations. When T-cells or B-cells receptors are activated, a series of phosphorylation leads to the recruitment of TEC to the cell membrane, where it is phosphorylated at Tyr-518. Also activated in response to SCF. Integrin engagement induces tyrosine phosphorylation of TEC in platelets. STAP1 participates in a positive feedback loop by increasing the activity of TEC. SOCS1 is an inhibitor of TEC kinase activity. {ECO:0000269|PubMed:10382746, ECO:0000269|PubMed:8621063, ECO:0000269|PubMed:8877094, ECO:0000269|PubMed:9872994}.
uniprot
proteins
amino_acid_sequence
MNFNTILEEILIKRSQQKKKTSLLNYKERLCVLPKSVLSYYEGRAEKKYRKGVIDISKIKCVEIVKNDDGVIPCQNKFPFQVVHDANTLYIFAPSPQSRDRWVKKLKEEIKNNNNIMIKYHPKFWADGSYQCCRQTEKLAPGCEKYNLFESSIRKTLPPAPEIKKRRPPPPIPPEEENTEEIVVAMYDFQATEAHDLRLERGQEYIILEKNDLHWWRARDKYGSEGYIPSNYVTGKKSNNLDQYEWYCRNTNRSKAEQLLRTEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDMLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLHRPKLATKYLYEVMLRCWQERPEGRPSLEDLLRTIDELVECEETFGR
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC also regulates FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-82'. May also be involved in the regulation of osteoclast differentiation. {ECO:0000269|PubMed:10382746, ECO:0000269|PubMed:15214045, ECO:0000269|PubMed:19688741, ECO:0000269|PubMed:21094130, ECO:0000269|PubMed:9473212, ECO:0000269|PubMed:9872994}.
uniprot
proteins
mass_dalton
73426
uniprot
proteins
mutagenesis
MUTAGEN 397; /note="K->M: Impairs kinase activity."; /evidence="ECO:0000269|PubMed:8621063
uniprot
proteins
post_translational_modification
PTM: Following B-cell or T-cell receptors engagement, translocates to the plasma membrane where it gets phosphorylated at Tyr-518. Undergoes also tyrosine phosphorylation during platelet activation. {ECO:0000269|PubMed:8621063, ECO:0000269|PubMed:8877094, ECO:0000269|PubMed:9473212}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TEC subfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10343129
uniprot
proteins
pubmed
10382746
uniprot
proteins
pubmed
11684687
uniprot
proteins
pubmed
15214045
uniprot
proteins
pubmed
15817477
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19688741
uniprot
proteins
pubmed
20543088
uniprot
proteins
pubmed
21094130
uniprot
proteins
pubmed
2284097
uniprot
proteins
pubmed
23478294
uniprot
proteins
pubmed
2482828
uniprot
proteins
pubmed
29348675
uniprot
proteins
pubmed
7678927
uniprot
proteins
pubmed
8621063
uniprot
proteins
pubmed
8877094
uniprot
proteins
pubmed
9473212
uniprot
proteins
pubmed
9872994
uniprot
proteins
sequence_length
630
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity). {ECO:0000250}.
uniprot
proteins