Pip4p1
entrez
219024
canonical
uniprot
Q3TWL2
canonical
ensembl
ENSMUSG00000035953
resolver
ensp
ENSMUSP00000038276
resolver
ensp
ENSMUSP00000123697
resolver
ensp
ENSMUSP00000124782
resolver
ensp
ENSMUSP00000125414
resolver
enst
ENSMUST00000049312
resolver
enst
ENSMUST00000160835
resolver
enst
ENSMUST00000161166
resolver
enst
ENSMUST00000162957
resolver
genesymbol
Pip4p1
resolver
genesymbol_syn
Tmem55b
resolver
uniprot
E0CZ18
resolver
uniprot
E0CZF6
resolver
uniprot
F8WHW3
resolver
uniprot_entry
E0CZ18_MOUSE
resolver
uniprot_entry
E0CZF6_MOUSE
resolver
uniprot_entry
F8WHW3_MOUSE
resolver
uniprot_entry
PP4P1_MOUSE
resolver
amino_acid_sequence
MAADGERSPLLSEAGDGGAGGNGLAGPGGSATGPGGGLTPSAPPYGAGKHAPPQAFPPFPEGHPAVLPGEDPPPYSPLTSPDSGSAPMITCRVCQSPINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPVHPGPLSPEPQPMGVRVICGHCKNTFLWTEFTDRTLARCPHCRKVSSIGRRYPRKRCICCFLLGLLLAVTATGLAFGTWKHAQQYGGIYAAWAFVILLAVLCLGRALYWACMKVSHPVQNFS
uniprot
proteins
ec_number
3.1.3.78
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (By similarity). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (PubMed:29644770). May play a role in the regulation of cellular cholesterol metabolism (By similarity). {ECO:0000250|UniProtKB:Q86T03, ECO:0000269|PubMed:29644770}.
uniprot
proteins
mass_dalton
30047
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29378918
uniprot
proteins
pubmed
29644770
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:29378918}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:29644770}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:29378918}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:29378918}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 219..239; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 246..266; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins