Fpgs
entrez
14287
canonical
uniprot
P48760
canonical
ensembl
ENSMUSG00000009566
resolver
ensp
ENSMUSP00000028148
resolver
genesymbol
Fpgs
resolver
uniprot
A2AK69
resolver
uniprot
Q3U0B4
resolver
uniprot
Q99K38
resolver
uniprot_entry
FOLC_MOUSE
resolver
uniprot_sec
A2AK69
resolver
uniprot_sec
Q3U0B4
resolver
uniprot_sec
Q99K38
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by ammonium sulfate. Inhibited by pentaglutamate derivative of DDATHF, but isoform 2 is inhibited to a greater extent at lower concentrations of the compound that is isoform 5. Isoform 5 is virtually unaffected by H(4)PteGlu(5) and 5,10-CH(2)-H(4)PteGlu(5) at concentrations that substantially inhibits the activity of isoform 2. Isoform 2 and 5 are equally sensitive to polyglutamates of 10-CHO-H(4)-PteGlu. {ECO:0000269|PubMed:11772020, ECO:0000269|PubMed:6548641}.
uniprot
proteins
amino_acid_sequence
MSWARSRLCSTLSLAAVSARGATTEGAARRGMSAWPAPQEPGMEYQDAVRTLNTLQTNASYLEQVKRQRSDPQAQLEAMEMYLARSGLQVEDLNRLNIIHVTGTKGKGSTCAFTERILRNYGLKTGFFSSPHMVQVRERIRINGKPISPELFTKHFWCLYNQLEEFKDDSHVSMPSYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAFDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIAWQKGGIFKPGVPAFTVVQPEGPLAVLRDRAQQIGCPLYLCPPLEALEEVGLPLSLGLEGAHQRSNAALALQLAHCWLERQDHQDIQELKVSRPSIRWQLPLAPVFRPTPHMRRGLRDTVWPGRTQILQRGPLTWYLDGAHTTSSVQACVHWYRQSLERSKRTDGGSEVHILLFNSTGDRDSAALLKLLQPCQFDYAVFCPNVTEVSSIGNADQQNFTVTLDQVLLRCLQHQQHWNGLAEKQASSNLWSSCGPDPAGPGSLLLAPHPPQPTRTSSLVFSCISHALLWISQGRDPIFQPQSLPRNLLNHPTANSGASILREAAAIHVLVTGSLHLVGGVLKLLDPSMSQ
uniprot
proteins
ec_number
6.3.2.17
uniprot
proteins
function
FUNCTION: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Dihydrofolate, tetrahydrofolate, 5,10-methylenetetrahydrofolate, 10-formyltetrahydrofolate and 5-formyltetrahydrofolate are the best substrates. Folic acid and 5-methyltetrahydrofolate can also act as substrates. {ECO:0000269|PubMed:11772020, ECO:0000269|PubMed:6548641}.
uniprot
proteins
mass_dalton
64955
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.
uniprot
proteins
protein_family
Folylpolyglutamate synthase family
uniprot
proteins
pubmed
10626793
uniprot
proteins
pubmed
11772020
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17998333
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
6548641
uniprot
proteins
pubmed
7592937
uniprot
proteins
pubmed
8605241
uniprot
proteins
pubmed
8798611
uniprot
proteins
pubmed
9038166
uniprot
proteins
sequence_length
587
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q05932}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q05932}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:Q05932}.
uniprot
proteins