Socs5
entrez
56468
canonical
uniprot
O54928
canonical
ensembl
ENSMUSG00000037104
resolver
ensp
ENSMUSP00000038591
resolver
ensp
ENSMUSP00000191873
resolver
ensp
ENSMUSP00000191877
resolver
ensp
ENSMUSP00000191879
resolver
enst
ENSMUST00000041369
resolver
genesymbol
Socs5
resolver
genesymbol_syn
Cish5
resolver
uniprot
Q7TSK1
resolver
uniprot_entry
SOCS5_MOUSE
resolver
uniprot_sec
Q7TSK1
resolver
amino_acid_sequence
MDKVGKMWNNLKYRCQNLFSHEGGSRNENVEMNPNRCPSVKEKSISLGEAAPQQESSPLRENVALQLGLSPSKTFSRRNQNCAAEIPQVVEISIEKDSDSGATPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDTEKKFGRTRSGLQRRERRYGVSSMQDMDSVSSRAVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDGSAIPQTNCDSEEDSTTLCLQSRRQKQRQVSGDSHAHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
uniprot
proteins
function
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. {ECO:0000269|PubMed:12242343}.
uniprot
proteins
mass_dalton
61086
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation is induced by EGF (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
12242343
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9419338
uniprot
proteins
sequence_length
536
uniprot
proteins