Dcps
entrez
266605
canonical
uniprot
Q8K4F7
canonical
ensembl
ENSRNOG00000072197
resolver
ensp
ENSRNOP00000013763
resolver
genesymbol
Dcps
resolver
genesymbol_syn
Dcs1
resolver
genesymbol_syn
Hint5
resolver
uniprot
F1LPT1
resolver
uniprot
Q3B8P4
resolver
uniprot_entry
DCPS_RAT
resolver
uniprot_entry
Q3B8P4_RAT
resolver
uniprot_sec
F1LPT1
resolver
activity_regulation
ACTIVITY REGULATION: The hydrolytic product 7-methylguanosine diphosphate (m7GDP) efficiently inhibits the decapping scavenger activity and acts as a competitive inhibitor in vitro. Inhibited by 2,4-diaminoquinazoline. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MADTAPQLKRKREQEAEEAETPSTEEKEAGVGNGTSAPVRLPFSGFRVQKVLRESARDKIIFLHGKVNEDSGDTHGEDAVVILEKTPFQVEHVAQLLTGNPELKLQFSNDIYSTYNLFPPRHLSDIKTTVVYPASEKHLQKYMRQDLRLIRETGDDYRSLTLPYLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILREGQEAILKRYQVTGDRLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAEVIENLECDPKHYQRRTLTFALRTDDPLLQLLQKAQQP
uniprot
proteins
ec_number
3.6.1.59
uniprot
proteins
function
FUNCTION: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death. {ECO:0000250}.
uniprot
proteins
mass_dalton
38714
uniprot
proteins
protein_family
HIT family
uniprot
proteins
sequence_length
336
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner. {ECO:0000250}.
uniprot
proteins