Cemip
entrez
80982
canonical
uniprot
Q8BI06
canonical
ensembl
ENSMUSG00000052353
resolver
ensp
ENSMUSP00000063277
resolver
genesymbol
Cemip
resolver
genesymbol_syn
9930013L23Rik
resolver
genesymbol_syn
Hybid
resolver
genesymbol_syn
Kiaa1199
resolver
uniprot
E9QJS6
resolver
uniprot
Q5M9P4
resolver
uniprot
Q6L9J4
resolver
uniprot
Q9EPQ3
resolver
uniprot
Q9EPQ4
resolver
uniprot_entry
CEMIP_MOUSE
resolver
uniprot_entry
Q5M9P4_MOUSE
resolver
uniprot_sec
E9QJS6
resolver
uniprot_sec
Q6L9J4
resolver
uniprot_sec
Q9EPQ3
resolver
uniprot_sec
Q9EPQ4
resolver
activity_regulation
ACTIVITY REGULATION: Activity is up-regulated by histamine. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MRASGRHDVSLKIVLATGCLLLANFSGASSAVATECPDQSPELQPWSPGHNRDYQVHIGHGRKLLLTSSATVHSITISGGGKLVIKDHHEHIVLRTRYILIDDGGELHAGSALCPFEGNFSIVLYGRADENILPDPYYGLKYIGVDKGGTLELHGQKKLSWTFLNKTLHPGGMQEGGYFFERSWGHRGVIVHVIDAKLGTVVHSDRFDTYRSKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDTARKAMTKLGSKHFLHLGFRHPWSFITVKGNPSSSVEDHIEYHGHKGSAAARVFKLFQTEHGEHFNVSSSSEWVQDVEWTEWFDHDKVPQSKGGEKISDLRAAYPGKICNRPIDIQATTMDGVALSTEVVYKNGQDYRFACYTRGRACRSYRVRFLCGKPVRPKLTVSIDTNVNSTILSLVDNVRSWRPGDTLVVASTDYSMYQAEEFRVLPCKACTSTQVKVAGKPQYLHIGEEIDGVDMRAEVGLLTRNIVVMGEMEDRCYPYTNHICDFFDFDTFGGHIKFALGFKAAHLEGVELKYMGQQLVGQYPIHFHLAGDLDEQGGYDPPTYIRDLSIHHTFSRCITVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSRMCKVITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVPTGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRAGMIIDNGVKTTEASAKDKRPFLSIISARYSPHQDADPLKPREPAIIRHFTAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQFYDGPINIQNCTFRKFAALEGRHTSALAFRLNNAWQSCPHNNVTNIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDLDGSVSEYPGSYLTKDDNWLVRHPDCINVPDWRGAICSGRYAQMYIQAYKSSNLRMKIIKNDFPSHPLYLEGALTRSTHYQQYQPVITLQKGYTIHWDQTAPAELAIWLINFNKGDWIRVGLCYPRGTTFSILSDVHNRLLKQTSKTGTFVRTLQMDKVEQSYPGRSHYYWDEDSGLLFLKLKAQNEREKFAFCSMKGCERIKIKALLPRNAGISDCTATAYPRFTERAIVDVPMPRKLFGAQLKTKDHFLEVKMESSRQHFFHLRNDFAYIEVDGRRYPCSEDGIQIVVIDGSRGHVVSHGSFRNAILQGIPWQLFNYVAAIPDNSIVLMASKGRYITRGPWTRVLEKLGADKGLKLKEKMAFVGFKGSFRPIWVTLETEDHKAKIFQVVPIPVVRKKKL
uniprot
proteins
ec_number
3.2.1.35
uniprot
proteins
function
FUNCTION: Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing. {ECO:0000269|PubMed:24251095}.
uniprot
proteins
mass_dalton
153034
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; glycosylation is not necessary for HA-binding. {ECO:0000250}.
uniprot
proteins
protein_family
CEMIP family
uniprot
proteins
pubmed
11247670
uniprot
proteins
pubmed
14577002
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18448257
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24251095
uniprot
proteins
sequence_length
1361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cell membrane {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:18448257, ECO:0000269|PubMed:24251095}. Secreted {ECO:0000250}. Note=Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP-dependent manner. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas (By similarity). Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. {ECO:0000250}.
uniprot
proteins