Nanos1
entrez
332397
canonical
uniprot
Q80WY3
canonical
ensembl
ENSMUSG00000072437
resolver
ensp
ENSMUSP00000096874
resolver
enst
ENSMUST00000088237
resolver
genesymbol
Nanos1
resolver
genesymbol_syn
Nos
resolver
uniprot
Q3UTS9
resolver
uniprot
Q8BIJ9
resolver
uniprot_entry
NANO1_MOUSE
resolver
uniprot_sec
Q3UTS9
resolver
uniprot_sec
Q8BIJ9
resolver
amino_acid_sequence
MEAFPWAPRSPRRARAPAPMALVPSARYVSASGPVHPQPFSSWNDYLGLATLITRASDRGSPHEGPGPTAAGPTMGPPEDDEDDDGEEPEAGGRYLGGALELRALELCAGPAEPGLLEERFAELNPFAGRAAAVLLGCAPTASTTAAAASTAEVTPREEPSPAWAAEPRLHAASGATAARLLKPELQVCVFCRNNKEAVALYTTHILKGPDGRVLCPVLRRYTCPLCGASGDNAHTIKYCPLSKVPPPTVRPPPRSNRDSLPSKKLR
uniprot
proteins
function
FUNCTION: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion (By similarity). Not essential for normal development. {ECO:0000250, ECO:0000269|PubMed:12834871}.
uniprot
proteins
mass_dalton
28151
uniprot
proteins
protein_family
Nanos family
uniprot
proteins
pubmed
12834871
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8WY41}. Cytoplasm {ECO:0000250|UniProtKB:Q8WY41}. Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells. {ECO:0000250|UniProtKB:Q8WY41}.
uniprot
proteins