Slc16a3
entrez
80878
canonical
uniprot
O35910
canonical
ensembl
ENSRNOG00000036677
resolver
ensembl
ENSRNOG00055032728
resolver
ensembl
ENSRNOG00060009296
resolver
ensembl
ENSRNOG00065004848
resolver
ensp
ENSRNOP00000051822
resolver
ensp
ENSRNOP00055046685
resolver
ensp
ENSRNOP00060012207
resolver
ensp
ENSRNOP00065004857
resolver
enst
ENSRNOT00000054939
resolver
enst
ENSRNOT00055056579
resolver
enst
ENSRNOT00060015664
resolver
enst
ENSRNOT00065007044
resolver
genesymbol
Slc16a3
resolver
genesymbol_syn
Mct3
resolver
genesymbol_syn
Mct4
resolver
uniprot
B4F761
resolver
uniprot_entry
B4F761_RAT
resolver
uniprot_entry
MOT4_RAT
resolver
amino_acid_sequence
MGGAVVDEGPTGIKAPDGGWGWAVLFGCFIITGFSYAFPKAVSVFFKELMHEFGIGYSDTAWISSILLAMLYGTGPLCSMCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQIYLTTGVITGLGLALNFQPSLIMLNRYFNKRRPMANGLAAAGSPVFLCALSPLGQLLQDHYGWRGGFLILGGLLLNCCVCAALMRPLVAPQASGGAEPHGPQRPSPRLLDLSVFRDRGFLIYAVAASIMVLGLFVPPVFVVSYAKDMGVPDTKAAFLLTILGFIDIFARPTAGFITGLKKVRPYSVYLFSFAMFFNGFTDLTGSTASDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLLEAVAVLIGPPSGGKLLDATKVYKYVFILAGAEVLTSSLVLLLGNFFCIGKRKRPEVTKPEEVASEEEKLHKPPVDVRVDSREVEHFLKAEPEKNGEVVHTPETSV
uniprot
proteins
function
FUNCTION: Proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate (By similarity) (PubMed:10926847, PubMed:9632638). Plays a predominant role in the L-lactate efflux from highly glycolytic cells (PubMed:10926847, PubMed:9632638). {ECO:0000250|UniProtKB:O15427, ECO:0000269|PubMed:10926847, ECO:0000269|PubMed:9632638}.
uniprot
proteins
mass_dalton
50549
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
10926847
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9632638
uniprot
proteins
sequence_length
471
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O15427}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O15427}. Basolateral cell membrane {ECO:0000250|UniProtKB:O15427}; Multi-pass membrane protein {ECO:0000255}. Note=Plasma membrane localization is dependent upon the BSG/MCT4 interaction. Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression in polarised epithelial cells. {ECO:0000250|UniProtKB:O15427}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 85..105; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 180..200; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 268..288; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 299..319; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 322..342; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 356..376; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 392..412; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins