Pik3ap1
entrez
83490
canonical
uniprot
Q9EQ32
canonical
ensembl
ENSMUSG00000025017
resolver
ensp
ENSMUSP00000052777
resolver
genesymbol
Pik3ap1
resolver
genesymbol_syn
Bcap
resolver
uniprot
Q2KHL6
resolver
uniprot
Q3TBW6
resolver
uniprot
Q3TC39
resolver
uniprot
Q3U5J3
resolver
uniprot
Q8BN25
resolver
uniprot
Q8C2Y4
resolver
uniprot_entry
BCAP_MOUSE
resolver
uniprot_sec
Q2KHL6
resolver
uniprot_sec
Q3TBW6
resolver
uniprot_sec
Q3TC39
resolver
uniprot_sec
Q3U5J3
resolver
uniprot_sec
Q8BN25
resolver
uniprot_sec
Q8C2Y4
resolver
amino_acid_sequence
MAASGWGRGCDILIFYSPDAEEWCQYLQDLFVSCRQVRSQKTQTYRLVPDASFSAQDLWVFRDARCVLVLLSAGLVGCFGQPGLLPMLQRACHPPQRVVRLLCGVQPGDEDFQAFFPDWAHWQEMTCDDEPETYLAAVRKAISEDSGCDSVTDTEPEDERELPFSKQTNLPPEISPGNLMVVQPDRIRCGAETTVYIIVRCKLDEKVSTEAEFSPEDSPSIRVEGTLENEYTVSVKAPDLSSGNVSLKVYSGDLVVCETTVSYYTDMEEIGNLLSSAANPVEFMCQAFKIVPYNTETLDKLLTESLKNNIPASGLHLFGINQLEEDDMMTNQRDEELPTLLHFAAKYGLKNLTALLLTCPGALQAYSVANKHGHYPNTIAEKHGFRDLRQFIDEYVETVDMLKTHIKEELMQGEEADDVYESMAHLSTDLLMKCSLNPGCDDELYESMAAFAPAATEDLYVEMLQASAGNPVSGESFSRPTKDSMIRKFLEGNSVKPASWEREQHHPYGEELYHIVDEDETFSVDLANRPPVPVPRPEASAPGPPPPPDNEPYISKVFAEKSQERLGNFYVSSESIRKEPLVRPWRDRPPSSIYDPFAGMKTPGQRQLITLQEQVKLGIVNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRESITRRRKEKPKSGKHTDLEITVPIRHSQHLPEKVEFGVYESGPRKSVLPARTELRRGDWKTDSMSSTASSTSNRSSTRSLLSVSSGMEGDNEDNEIPEITRSRGPGPTQVDGAPVVTGTPVGTLERPPRVPPRAASQRPLTRESFHPPPPVPPRGR
uniprot
proteins
function
FUNCTION: Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:11781242, ECO:0000269|PubMed:11877477, ECO:0000269|PubMed:12833156, ECO:0000269|PubMed:18025150, ECO:0000269|PubMed:18337558, ECO:0000269|PubMed:22187458, ECO:0000269|PubMed:22187460}.
uniprot
proteins
mass_dalton
90928
uniprot
proteins
mutagenesis
MUTAGEN 264; /note="Y->F: Fails to bind PIK3R1 in a BCR-signaling dependent manner; when associated with Y-420; Y-445 and Y-460. Loss of regulatory function in Toll-like receptor signaling probably due to loss of interaction with PIK3R1; when associated with Y-420; Y-445 and Y-460. Impairs mature B-cell generation; when associated with Y-420; Y-445 and Y-460."; /evidence="ECO:0000269|PubMed:18025150"; MUTAGEN 420; /note="Y->F: Fails to bind PIK3R1 in a BCR-signaling dependent manner; when associated with Y-264; Y-445 and Y-460. Loss of regulatory function in Toll-like receptor signaling probably due to loss of interaction with PIK3R1; when associated with Y-264; Y-445 and Y-460. Impairs mature B-cell generation; when associated with Y-264; Y-445 and Y-460."; /evidence="ECO:0000269|PubMed:18025150"; MUTAGEN 445; /note="Y->F: Fails to bind PIK3R1 in a BCR-signaling dependent manner; when associated with Y-264; Y-420 and Y-460. Loss of regulatory function in Toll-like receptor signaling probably due to loss of interaction with PIK3R1; when associated with Y-264; Y-420 and Y-460. Impairs mature B-cell generation; when associated with Y-264; Y-420 and Y-460."; /evidence="ECO:0000269|PubMed:18025150"; MUTAGEN 460; /note="Y->F: Fails to bind PIK3R1 in a BCR-signaling dependent manner; when associated with Y-264; Y-420 and Y-445. Loss of regulatory function in Toll-like receptor signaling probably due to loss of interaction with PIK3R1; when associated with Y-264; Y-420 and Y-445. Impairs mature B-cell generation; when associated with Y-264; Y-420 and Y-445."; /evidence="ECO:0000269|PubMed:18025150
uniprot
proteins
post_translational_modification
PTM: Constitutively phosphorylated. Phosphorylated on tyrosine residues in C-terminal region by ABL1 (By similarity). Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK. Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation. Toll-like receptor activation induces appearance of a phosphorylated form associated with membranes. {ECO:0000250, ECO:0000269|PubMed:11163197, ECO:0000269|PubMed:18025150, ECO:0000269|PubMed:20728433, ECO:0000269|PubMed:22187458, ECO:0000269|PubMed:22187460}.
uniprot
proteins
pubmed
11163197
uniprot
proteins
pubmed
11781242
uniprot
proteins
pubmed
11877477
uniprot
proteins
pubmed
12767830
uniprot
proteins
pubmed
12833156
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18025150
uniprot
proteins
pubmed
18337558
uniprot
proteins
pubmed
20728433
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22187458
uniprot
proteins
pubmed
22187460
uniprot
proteins
sequence_length
811
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22187458}. Cell membrane {ECO:0000305|PubMed:22187458}; Peripheral membrane protein {ECO:0000305|PubMed:22187458}.
uniprot
proteins