Tsc22d1
entrez
498545
canonical
uniprot
P62501
canonical
ensembl
ENSRNOG00000001030
resolver
ensembl
ENSRNOG00000079081
resolver
ensp
ENSRNOP00000001360
resolver
ensp
ENSRNOP00000085587
resolver
enst
ENSRNOT00000110281
resolver
genesymbol
Tsc22d1
resolver
genesymbol_syn
Tgfb1i4
resolver
genesymbol_syn
Tsc22
resolver
uniprot
A0A8I6A468
resolver
uniprot
A0JPR0
resolver
uniprot
D3Z8M8
resolver
uniprot
Q00992
resolver
uniprot_entry
A0A8I6A468_RAT
resolver
uniprot_entry
T22D1_RAT
resolver
uniprot_sec
A0JPR0
resolver
uniprot_sec
D3Z8M8
resolver
uniprot_sec
Q00992
resolver
amino_acid_sequence
MHQPPESTAAAAAAADISARKMAHPAMFPRRGSGGGSASALSAAGTGVSGAAPSSEDFPPPSSLLQPPPPAASSTQGPQPPPPQSLNLLSQAQLQGQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHHLHHHHHIHHGHHLHHGHHHSSHAAVASTSVPGGPPPTSPVSRKLSTAGSSDGGVPVPPTSAVSSAGLPASVMTSIRAPSTPGSIGVNSVTGTNATNNVNIAAVGGFSPGVANSVHPNAVSISGGPGVTSGVNVNVLSGMGNGTISSPVLNAAAGITVGVVSSQQQQPQQPPPTVNTSRFRVVKLDSTSEPFKKGRWTCTEFYERENAVPGPEGVAINKVVETVKQTPTEASSSERESTSGSSVSSSVSTLSHYTESVGSGEMGAPTVVVQQQQPLPPAPPGLQGVALQQLDFSSPGPQSISQSQMSQVQLQPQELSFQQKPNLQPVPLQATMSAATGIQPSPVNVVGVTSAVGQQPSISSLAQPQLPYPQPAPPVQTPLPGAPPQQLQYGQQQPMVPTQIAPGHGQPATQNPPSEYAQQQPIFQAAMSSGQSSSTGTGASVIPVAQPQGIQLPVQPTAVQAQPAGATGQPIGQAPTAVSTVPAGGQIASIGQQANIPTAVQPPSTQVTPSVVQQGAPPSSQVVLPAPTGIIHQGVQTSAPSLPQQLVIAPQSTMVAVPPQTQGVEAVAHGVVSHQLPTGSPLPSASTISVTSQVSSAGPSGMSSVPTNLVPPQNIAQPPATQNGSLVQSVSQSPLIATNINLPLAQQIPLSSTQFSTQSLAQAIGSQMEDTRRPAEPSSGGLPQTLSGDSGGVSAVSDGSSSSLAASASLFPLKVLPLTTPLVDGEDESSGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPPAQPASQGSGSTA
uniprot
proteins
function
FUNCTION: Transcriptional repressor (By similarity). Acts on the C-type natriuretic peptide (CNP) promoter (By similarity). Acts to promote CASP3-mediated apoptosis (By similarity). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (By similarity). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (By similarity). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (By similarity). {ECO:0000250|UniProtKB:P62500, ECO:0000250|UniProtKB:Q15714}.; FUNCTION: [Isoform 1]: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. {ECO:0000250|UniProtKB:P62500}.; FUNCTION: [Isoform 2]: Positively regulates cell death in response to TGFB3 during mammary gland involution. {ECO:0000250|UniProtKB:P62500}.
uniprot
proteins
mass_dalton
106786
uniprot
proteins
protein_family
TSC-22/Dip/Bun family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21791611
uniprot
proteins
pubmed
8161377
uniprot
proteins
pubmed
9022669
uniprot
proteins
sequence_length
1050
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62500}. Nucleus {ECO:0000250|UniProtKB:P62500}. Cell membrane {ECO:0000250|UniProtKB:Q15714}; Peripheral membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250|UniProtKB:Q15714}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:Q15714}. Nucleus {ECO:0000250|UniProtKB:Q15714}. Mitochondrion {ECO:0000250|UniProtKB:Q15714}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:Q15714}. Nucleus {ECO:0000250|UniProtKB:Q15714}. Mitochondrion {ECO:0000250|UniProtKB:Q15714}.
uniprot
proteins