Dhdds
entrez
67422
canonical
uniprot
Q99KU1
canonical
ensembl
ENSMUSG00000012117
resolver
ensp
ENSMUSP00000012262
resolver
ensp
ENSMUSP00000101511
resolver
ensp
ENSMUSP00000116098
resolver
ensp
ENSMUSP00000220907
resolver
ensp
ENSMUSP00000220908
resolver
ensp
ENSMUSP00000220917
resolver
genesymbol
Dhdds
resolver
uniprot
A3KGL4
resolver
uniprot
Q3UF13
resolver
uniprot
Q8BZ16
resolver
uniprot
Q8BZK8
resolver
uniprot_entry
DHDDS_MOUSE
resolver
uniprot_sec
A3KGL4
resolver
uniprot_sec
Q3UF13
resolver
uniprot_sec
Q8BZ16
resolver
uniprot_sec
Q8BZK8
resolver
amino_acid_sequence
MSWIKEGELSLWERFCANIIKAGPVPKHIAFIMDGNRRYAKKCQVERQEGHTQGFNKLAETLRWCLNLGILEVTVYAFSIENFKRSKSEVDGLLDLARQKFSCLMEEQEKLQKHGVCIRVLGDLHLLPLDLQEKIAHAIQATKNYNKCFLNVCFAYTSRHEIANAVREMAWGVEQGLLEPSDVSESLLDKCLYSNHSPHPDILIRTSGEVRLSDFLLWQTSHSCLVFQPVLWPEYTFWNLCEAILQFQRNHGALQKARDMYAEERKRRQLERDQAAVTEQLLREGLQASGDAQLRRTRLHKLSTKREERVQGFLKALELKRANWLALWGTASA
uniprot
proteins
ec_number
2.5.1.87
uniprot
proteins
function
FUNCTION: With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. {ECO:0000250|UniProtKB:Q86SQ9}.
uniprot
proteins
mass_dalton
38509
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="K->E: Impaired formation of dolichol species, leading to defects in inner retina and synaptic transmission in knockin mice. Knockin mice do notshow retinal degeneration."; /evidence="ECO:0000269|PubMed:32272552, ECO:0000269|PubMed:37443173
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q86SQ9}.; PATHWAY: Lipid metabolism. {ECO:0000250|UniProtKB:Q86SQ9}.
uniprot
proteins
protein_family
UPP synthase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
32245241
uniprot
proteins
pubmed
32272552
uniprot
proteins
pubmed
32526701
uniprot
proteins
pubmed
37443173
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q86SQ9}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q86SQ9}. Note=colocalizes with calnexin. {ECO:0000250|UniProtKB:Q86SQ9}.
uniprot
proteins