Q63618
uniprot
Q63618
canonical
amino_acid_sequence
MALEQAMQAARRGDLDVLRSLHAAGLLGPSLRDPLDALPVHHAARSGKLHCLRYLVEEVALPAVSRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGGANSAITTDTGALPIHYAAAKGDLPSMKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFADVSFEQDHDGATAMHFAASRGHTKVLSWLLLHGAEISQDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLADFNGHTHCSRYLRTVQTLSLEHRVLSRDPSMDLEAKQPDSGMSSPNTTMSVQPPNFDLGSPTSTLSNYDSCSSSHSSSKGQRSTRGARSSDLQSYMDMLNPEPRSKQGKPSSLPPPPPPSFPPPPPPGTQLPPPPPGYPAPNPPVGLHLDNIYMQTKNKLRHVEVDSLKKEPSSGDGYSGLRRQDSGLLRQDSELLLRHNTGLRRQDSDRKQRSFSKQPSTGDYYRQLGRSPGEPLAARPGMAHSEEAALLPGNHVHNGCSADSKASRELPPPPPPPPLPEALSSPPPAPPLPIEGAGAACGQRRSSSSTGSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGSGQPASQPESPQPAVSPGPSRARSPTPPASGPQPLLNGSIVPAPPATLAPGVHLDVEALIPTLDEQGRPIPEWKRQVMVRKLQQKMQEEEEQRRKEEEEEARLASLPAWRRDILRKKLEEEREQKRKEEERQKLEEIQRAKEQSEKLRTLGYDEAKLAPWQRQVILKKGEIPK
uniprot
proteins
function
FUNCTION: Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells (PubMed:9763424). Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation (By similarity). {ECO:0000250|UniProtKB:Q9ET47, ECO:0000269|PubMed:9763424}.
uniprot
proteins
mass_dalton
90569
uniprot
proteins
pubmed
12598619
uniprot
proteins
pubmed
15190118
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8799813
uniprot
proteins
pubmed
9763424
uniprot
proteins
sequence_length
837
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q9ET47}. Cell projection, microvillus. Cell junction.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton. Cell junction. Note=Isoform 1 localizes to parallel actin bundles of ectoplasmic specializations between neighboring Sertoli cells and at sites where Sertoli cells contact the heads of elongate spermatids.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton. Cell projection, microvillus. Note=Isoform 2 localizes to parallel actin bundles of brush border microvilli of small intestine and kidney.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.; SUBCELLULAR LOCATION: [Isoform 8]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.
uniprot
proteins