TENT5B
entrez
115572
canonical
uniprot
Q96A09
canonical
ensembl
ENSG00000158246
resolver
ensp
ENSP00000289166
resolver
enst
ENST00000289166
resolver
genesymbol
TENT5B
resolver
genesymbol_syn
FAM46B
resolver
hgnc
HGNC:28273
resolver
uniprot_entry
TET5B_HUMAN
resolver
amino_acid_sequence
MMPSESGAERRDRAAAQVGTAAATAVATAAPAGGGPDPEALSAFPGRHLSGLSWPQVKRLDALLSEPIPIHGRGNFPTLSVQPRQIVQVVRSTLEEQGLHVHSVRLHGSAASHVLHPESGLGYKDLDLVFRVDLRSEASFQLTKAVVLACLLDFLPAGVSRAKITPLTLKEAYVQKLVKVCTDSDRWSLISLSNKSGKNVELKFVDSVRRQFEFSIDSFQIILDSLLLFGQCSSTPMSEAFHPTVTGESLYGDFTEALEHLRHRVIATRSPEEIRGGGLLKYCHLLVRGFRPRPSTDVRALQRYMCSRFFIDFPDLVEQRRTLERYLEAHFGGADAARRYACLVTLHRVVNESTVCLMNHERRQTLDLIAALALQALAEQGPAATAALAWRPPGTDGVVPATVNYYVTPVQPLLAHAYPTWLPCN
uniprot
proteins
ec_number
2.7.7.19
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group in an ATP hydrolysis-dependent manner (PubMed:32009146, PubMed:34048638). May be involved in maintaining the translation efficiency of at least some genes through preventing degradation of their mRNAs (PubMed:32009146). Prefers RNA molecules that are adenosine-rich close to 3'-end (PubMed:32009146). In addition, may inhibit cell proliferation and cell cycle progression through ubiquitination of beta-catenin/CTNNB1 (PubMed:30532005). {ECO:0000269|PubMed:30532005, ECO:0000269|PubMed:32009146, ECO:0000269|PubMed:34048638}.
uniprot
proteins
mass_dalton
46688
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="G->A: Loss of polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 109; /note="S->A: Loss of polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 124; /note="K->A: Does not affect polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 125; /note="D->A: Loss of polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 127; /note="D->A: Loss of polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 176; /note="K->A: Loss of polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 179; /note="K->A: Loss of polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 181; /note="C->A: Reduces polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 201; /note="E->A: Loss of polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 203; /note="K->A: Loss of polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 210; /note="R->A: Loss of polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 213; /note="E->A: Substantially reduces polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 216; /note="I->S: Substantially reduces polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 269; /note="R->A: Substantially reduces polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 272; /note="E->A: Substantially reduces polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 275; /note="R->A: Loss of polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 281; /note="K->A: Loss of polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 303; /note="R->A: Does not affect polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 321; /note="R->A: Loss of polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 330; /note="H->A: Loss of polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146"; MUTAGEN 331; /note="F->A: Does not affect polyadenylation activity."; /evidence="ECO:0000269|PubMed:32009146
uniprot
proteins
protein_family
TENT family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
30532005
uniprot
proteins
pubmed
32009146
uniprot
proteins
pubmed
34048638
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32009146}. Nucleus {ECO:0000269|PubMed:32009146}.
uniprot
proteins