CUX1
entrez
1523
canonical
uniprot
P39880
canonical
uniprot
Q13948
canonical
ensembl
ENSG00000257923
resolver
ensp
ENSP00000292535
resolver
ensp
ENSP00000353401
resolver
ensp
ENSP00000377410
resolver
ensp
ENSP00000409745
resolver
ensp
ENSP00000414091
resolver
ensp
ENSP00000446630
resolver
ensp
ENSP00000449371
resolver
ensp
ENSP00000484760
resolver
ensp
ENSP00000494610
resolver
ensp
ENSP00000496653
resolver
ensp
ENSP00000605738
resolver
ensp
ENSP00000634742
resolver
ensp
ENSP00000665051
resolver
genesymbol
CUX1
resolver
genesymbol
Nbla10317
resolver
genesymbol_syn
CUTL1
resolver
hgnc
HGNC:2557
resolver
uniprot
B3KV79
resolver
uniprot
B3KWH3
resolver
uniprot
B3KWH8
resolver
uniprot
B4DZZ2
resolver
uniprot
G3V1Z6
resolver
uniprot
J3KPQ6
resolver
uniprot
J3KQV9
resolver
uniprot
Q3LIA3
resolver
uniprot
Q53GU9
resolver
uniprot
Q6NYH4
resolver
uniprot
Q75LE5
resolver
uniprot
Q75MT2
resolver
uniprot
Q75MT3
resolver
uniprot
Q86UJ7
resolver
uniprot
Q8TBS3
resolver
uniprot
Q9UEV5
resolver
uniprot_entry
CASP_HUMAN
resolver
uniprot_entry
CUX1_HUMAN
resolver
uniprot_entry
Q3LIA3_HUMAN
resolver
uniprot_sec
B3KV79
resolver
uniprot_sec
B3KWH3
resolver
uniprot_sec
B3KWH8
resolver
uniprot_sec
B4DZZ2
resolver
uniprot_sec
G3V1Z6
resolver
uniprot_sec
J3KPQ6
resolver
uniprot_sec
J3KQV9
resolver
uniprot_sec
Q53GU9
resolver
uniprot_sec
Q6NYH4
resolver
uniprot_sec
Q75LE5
resolver
uniprot_sec
Q75MT2
resolver
uniprot_sec
Q75MT3
resolver
uniprot_sec
Q86UJ7
resolver
uniprot_sec
Q8TBS3
resolver
uniprot_sec
Q9UEV5
resolver
amino_acid_sequence
MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHENDNGAAAGDLWQ
uniprot
proteins
amino_acid_sequence
MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPPPSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEPIEWEF
uniprot
proteins
disease_involvement
DISEASE: Neurodevelopmental disorder with developmental delay and with or without motor or speech delay (NEDDMS) [MIM:618330]: An autosomal dominant disorder characterized by global developmental delay associated with mild-to-moderate intellectual disability, hypotonia and short stature in some patients. {ECO:0000269|PubMed:30014507}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May be involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:15718469}.
uniprot
proteins
function
FUNCTION: Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.
uniprot
proteins
mass_dalton
164187
uniprot
proteins
mass_dalton
77455
uniprot
proteins
mutagenesis
MUTAGEN 624; /note="Y->L: Retained in the endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:12429822"; MUTAGEN 629; /note="H->L: No effect on subcellular location."; /evidence="ECO:0000269|PubMed:12429822
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA. {ECO:0000250|UniProtKB:P53565}.; PTM: As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa by CTSL. Cell cycle-dependent processing of CUX1 serves to generate a CDP/Cux p110 with distinct DNA binding and transcriptional properties. {ECO:0000269|PubMed:15099520}.
uniprot
proteins
protein_family
CASP family
uniprot
proteins
protein_family
CUT homeobox family
uniprot
proteins
pubmed
10607901
uniprot
proteins
pubmed
12429822
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
1301999
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15099520
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15718469
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
30014507
uniprot
proteins
pubmed
9332351
uniprot
proteins
pubmed
9799793
uniprot
proteins
sequence_length
1505
uniprot
proteins
sequence_length
678
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:12429822}; Single-pass type IV membrane protein {ECO:0000269|PubMed:12429822}.
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15099520}.
uniprot
proteins
transmembrane_region
TRANSMEM 620..640; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins