Gabrb2
entrez
25451
canonical
uniprot
P63138
canonical
ensembl
ENSRNOG00000003680
resolver
ensembl
ENSRNOG00055005326
resolver
ensembl
ENSRNOG00060020559
resolver
ensembl
ENSRNOG00065001348
resolver
ensp
ENSRNOP00000004970
resolver
ensp
ENSRNOP00000081083
resolver
ensp
ENSRNOP00055006492
resolver
ensp
ENSRNOP00060029279
resolver
ensp
ENSRNOP00065001244
resolver
enst
ENSRNOT00000004970
resolver
enst
ENSRNOT00000118632
resolver
enst
ENSRNOT00055008556
resolver
enst
ENSRNOT00060035613
resolver
enst
ENSRNOT00065001787
resolver
genesymbol
Gabrb2
resolver
genesymbol_syn
Gabrb-2
resolver
uniprot
A0A8L2Q2J9
resolver
uniprot
P15432
resolver
uniprot_entry
A0A8L2Q2J9_RAT
resolver
uniprot_entry
GBRB2_RAT
resolver
uniprot_sec
P15432
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by benzodiazepines and the anesthetic etomidate (By similarity). Inhibited by the antagonist bicuculline (By similarity). Potentiated by histamine (PubMed:18281286). {ECO:0000250|UniProtKB:P0C2W5, ECO:0000250|UniProtKB:P47870, ECO:0000269|PubMed:18281286}.
uniprot
proteins
amino_acid_sequence
MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAANANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
uniprot
proteins
function
FUNCTION: Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:1660002, PubMed:2548852). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:1660002). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity). Extrasynaptic beta-2 receptors contribute to the tonic GABAergic inhibition (PubMed:9464994). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (PubMed:18281286). {ECO:0000250|UniProtKB:P08219, ECO:0000250|UniProtKB:P47870, ECO:0000269|PubMed:1660002, ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:2548852, ECO:0000269|PubMed:9464994}.
uniprot
proteins
mass_dalton
54633
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:P63137}.
uniprot
proteins
protein_family
GABRB2 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
11528422
uniprot
proteins
pubmed
1660002
uniprot
proteins
pubmed
17003036
uniprot
proteins
pubmed
18281286
uniprot
proteins
pubmed
25172774
uniprot
proteins
pubmed
2548852
uniprot
proteins
pubmed
28279354
uniprot
proteins
pubmed
9464994
uniprot
proteins
sequence_length
474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:9464994}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P47870}. Cell membrane {ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:9464994}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P47870}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:25172774}. Note=The beta-2 subunits are present in Golgi synapses and on the extrasynaptic membranes (alpha-1/6-beta-2/3-gamma-2 receptors), and in some of the mossy fiber to granule cell synapses (alpha-6-beta-2/3-gamma-2 receptors). Present in GABAergic and glutamatergic synapses on granule cells (PubMed:9464994). The beta-2 subunit (alpha-6-beta-2/3-delta receptors) are found only on the extrasynaptic somatic and dendritic membranes (PubMed:9464994). {ECO:0000269|PubMed:9464994}.
uniprot
proteins
transmembrane_region
TRANSMEM 245..266; /note="Helical"; /evidence="ECO:0000305"; TRANSMEM 270..292; /note="Helical"; /evidence="ECO:0000305"; TRANSMEM 304..326; /note="Helical"; /evidence="ECO:0000305"; TRANSMEM 452..473; /note="Helical"; /evidence="ECO:0000305
uniprot
proteins