Dvl1
entrez
13542
canonical
uniprot
P51141
canonical
ensembl
ENSMUSG00000029071
resolver
ensp
ENSMUSP00000030948
resolver
ensp
ENSMUSP00000133137
resolver
ensp
ENSMUSP00000257361
resolver
ensp
ENSMUSP00000257362
resolver
ensp
ENSMUSP00000257363
resolver
ensp
ENSMUSP00000257365
resolver
ensp
ENSMUSP00000257370
resolver
ensp
ENSMUSP00000257383
resolver
enst
ENSMUST00000030948
resolver
enst
ENSMUST00000168552
resolver
genesymbol
Dvl1
resolver
genesymbol_syn
Dvl
resolver
uniprot
Q3U2D3
resolver
uniprot
Q60868
resolver
uniprot_entry
DVL1_MOUSE
resolver
uniprot_sec
Q3U2D3
resolver
uniprot_sec
Q60868
resolver
amino_acid_sequence
MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNRDEAARTNGHPRGDRRRDLGLPPDSASTVLSSELESSSFIDSDEEDNTSRLSSSTEQSTSSRLVRKHKCRRRKQRLRQTDRASSFSSITDSTMSLNIITVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTIPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAITRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAIVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSMLKHGFLRHTVNKITFSEQCYYVFGDLCSNLASLNLNSGSSGASDQDTLAPLPHPSVPWPLGQGYPYQYPGPPPCFPPAYQDPGFSCGSGSAGSQQSEGSKSSGSTRSSHRTPGREERRATGAGGSGSESDHTVPSGSGSTGWWERPVSQLSRGSSPRSQASAVAPGLPPLHPLTKAYAVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM
uniprot
proteins
function
FUNCTION: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). {ECO:0000269|PubMed:11101902, ECO:0000269|PubMed:12165471, ECO:0000269|PubMed:15353129, ECO:0000269|PubMed:19637179}.
uniprot
proteins
mass_dalton
75359
uniprot
proteins
mutagenesis
MUTAGEN 17; /note="Y->D: Loss of oligomerization."; /evidence="ECO:0000269|PubMed:21189423"; MUTAGEN 438; /note="K->M: Strongly reduces activity in Wnt signaling. Abolishes location at the cell membrane."; /evidence="ECO:0000269|PubMed:11101902, ECO:0000269|PubMed:15353129"; MUTAGEN 449; /note="D->I: Reduces activity in Wnt signaling; when associated with I-452."; /evidence="ECO:0000269|PubMed:11101902"; MUTAGEN 452; /note="D->I: Reduces activity in Wnt signaling; when associated with I-449."; /evidence="ECO:0000269|PubMed:11101902
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination (By similarity). Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. {ECO:0000250, ECO:0000269|PubMed:20227366}.
uniprot
proteins
protein_family
DSH family
uniprot
proteins
pubmed
11101902
uniprot
proteins
pubmed
12165471
uniprot
proteins
pubmed
12941796
uniprot
proteins
pubmed
14636582
uniprot
proteins
pubmed
15353129
uniprot
proteins
pubmed
15454084
uniprot
proteins
pubmed
15456783
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16604061
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19637179
uniprot
proteins
pubmed
20227366
uniprot
proteins
pubmed
21189423
uniprot
proteins
pubmed
27214281
uniprot
proteins
pubmed
7958461
uniprot
proteins
pubmed
9132266
uniprot
proteins
pubmed
9298901
uniprot
proteins
sequence_length
695
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15353129}; Peripheral membrane protein {ECO:0000269|PubMed:15353129}; Cytoplasmic side {ECO:0000269|PubMed:15353129}. Cytoplasm, cytosol {ECO:0000269|PubMed:15353129}. Cytoplasmic vesicle {ECO:0000269|PubMed:15353129}. Note=Localizes at the cell membrane upon interaction with frizzled family members.
uniprot
proteins