Inhibition of host PKR by virus
uniprot_keyword
KW-1102
canonical
name
Inhibition of host PKR by virus
uniprot
definition
Viral protein involved in the evasion of the interferon pathway by inhibiting the interferon induced PKR/EIF2AK2 protein. During viral replication of RNA viruses, dsRNA is produced leading to the activation of the PKR/EIF2AK2 kinase. Once activated, PKR/EIF2AK2 autophosphorylates and catalyzes the phosphorylation of many substrates including the translation initiation factor EIF2S1, leading to the inhibition of the initiation of protein synthesis. Several viral proteins prevent PKR/EIF2AK2 activation by direct interaction while others target PKR/EIF2AK2 to degradation.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
uniprot_keywords
uniprot
keywords