CD82
entrez
3732
canonical
uniprot
P27701
canonical
ensembl
ENSG00000085117
resolver
ensp
ENSP00000227155
resolver
ensp
ENSP00000339686
resolver
ensp
ENSP00000548623
resolver
ensp
ENSP00000638220
resolver
genesymbol
CD82
resolver
genesymbol_syn
KAI1
resolver
genesymbol_syn
SAR2
resolver
genesymbol_syn
ST6
resolver
genesymbol_syn
TSPAN27
resolver
hgnc
HGNC:6210
resolver
uniprot
D3DQN6
resolver
uniprot
E9PC70
resolver
uniprot
Q7Z2D4
resolver
uniprot
Q7Z5N2
resolver
uniprot_entry
CD82_HUMAN
resolver
uniprot_sec
D3DQN6
resolver
uniprot_sec
E9PC70
resolver
uniprot_sec
Q7Z2D4
resolver
uniprot_sec
Q7Z5N2
resolver
amino_acid_sequence
MGSACIKVTKYFLFLFNLIFFILGAVILGFGVWILADKSSFISVLQTSSSSLRMGAYVFIGVGAVTMLMGFLGCIGAVNEVRCLLGLYFAFLLLILIAQVTAGALFYFNMGKLKQEMGGIVTELIRDYNSSREDSLQDAWDYVQAQVKCCGWVSFYNWTDNAELMNRPEVTYPCSCEVKGEEDNSLSVRKGFCEAPGNRTQSGNHPEDWPVYQEGCMEKVQAWLQENLGIILGVGVGVAIIELLGMVLSICLCRHVHSEDYSKVPKY
uniprot
proteins
function
FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling (PubMed:19497983). Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Acts as a attenuator of EGF signaling, facilitating ligand-induced endocytosis of the receptor and its subsequent desensitization (PubMed:10985391, PubMed:35538033). Mechanistically, modulates ligand-induced ubiquitination and trafficking of EGFR via E3 ligase CBL phosphorylation by PKC (PubMed:23897813). Increases cell-matrix adhesion by regulating the membrane organization of integrin alpha4/ITA4 (PubMed:24623721, PubMed:8757325). Modulates adhesion and suppresses cell migration through other integrins such as the alpha6/ITGA6 and beta1/ITGB1 (PubMed:15557282, PubMed:17560548). Decreases cell-associated plasminogen activation by interfering with the interaction between urokinase-type plasminogen activator/PLAU and its receptor PLAUR (PubMed:15677461). Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. Plays a role in TLR9 trafficking to acidified CpG-containing compartments by controlling interaction between TLR9 and VAMP3 and subsequent myddosome assembly (By similarity). Inhibits LPS-induced inflammatory response by preventing binding of LPS to TLR4 on the cell surface (PubMed:36945827). Plays a role in the activation of macrophages into anti-inflammatory phenotypes (By similarity). Independently of Toll-like receptor (TLR) signaling, is recruited to pathogen-containing phagosomes prior to fusion with lysosomes and thereby participates in antigen presentation (By similarity). Also acts to control angiogenesis and switch angiogenic milieu to quiescent state by binding and sequestering VEGFA and PDGFB to inhibit the signaling they trigger via their respective cell surface receptor (PubMed:34530889). {ECO:0000250|UniProtKB:P40237, ECO:0000269|PubMed:10985391, ECO:0000269|PubMed:12750295, ECO:0000269|PubMed:15557282, ECO:0000269|PubMed:15677461, ECO:0000269|PubMed:19497983, ECO:0000269|PubMed:23897813, ECO:0000269|PubMed:24623721, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:36945827, ECO:0000269|PubMed:8757325}.
uniprot
proteins
mass_dalton
29626
uniprot
proteins
mutagenesis
MUTAGEN 5; /note="C->S: Strong decrease in the expressions of CD82 and EGFR on the cell membrane; when associated with S-74."; /evidence="ECO:0000269|PubMed:35538033"; MUTAGEN 74; /note="C->S: Strong decrease in the expressions of CD82 and EGFR on the cell membrane; when associated with S-5."; /evidence="ECO:0000269|PubMed:35538033
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Palmitoylation contributes to oligomerization and surface expression. {ECO:0000269|PubMed:24623721, ECO:0000269|PubMed:34530889, ECO:0000269|PubMed:35538033}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
10985391
uniprot
proteins
pubmed
12750295
uniprot
proteins
pubmed
1401919
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15557282
uniprot
proteins
pubmed
15677461
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17560548
uniprot
proteins
pubmed
1842498
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19497983
uniprot
proteins
pubmed
23897813
uniprot
proteins
pubmed
24623721
uniprot
proteins
pubmed
30463011
uniprot
proteins
pubmed
34530889
uniprot
proteins
pubmed
35538033
uniprot
proteins
pubmed
36945827
uniprot
proteins
pubmed
7754374
uniprot
proteins
pubmed
8757325
uniprot
proteins
pubmed
9126478
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19497983, ECO:0000269|PubMed:23897813, ECO:0000269|PubMed:30463011, ECO:0000269|PubMed:34530889, ECO:0000269|PubMed:8757325, ECO:0000269|Ref.4}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P40237}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 54..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 229..250; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins