NXF1
entrez
10482
canonical
uniprot
Q9UBU9
canonical
ensembl
ENSG00000162231
resolver
ensp
ENSP00000294172
resolver
ensp
ENSP00000453885
resolver
genesymbol
NXF1
resolver
genesymbol_syn
TAP
resolver
hgnc
HGNC:8071
resolver
uniprot
B4E269
resolver
uniprot
Q59E96
resolver
uniprot
Q99799
resolver
uniprot
Q9UQL2
resolver
uniprot_entry
NXF1_HUMAN
resolver
uniprot_entry
Q59E96_HUMAN
resolver
uniprot_sec
B4E269
resolver
uniprot_sec
Q99799
resolver
uniprot_sec
Q9UQL2
resolver
amino_acid_sequence
MADEGKSYSEHDDERVNFPQRKKKGRGPFRWKYGEGNRRSGRGGSGIRSSRLEEDDGDVAMSDAQDGPRVRYNPYTTRPNRRGDTWHDRDRIHVTVRRDRAPPERGGAGTSQDGTSKNWFKITIPYGRKYDKAWLLSMIQSKCSVPFTPIEFHYENTRAQFFVEDASTASALKAVNYKILDRENRRISIIINSSAPPHTILNELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELWLDGNSLCDTFRDQSTYISAIRERFPKLLRLDGHELPPPIAFDVEAPTTLPPCKGSYFGTENLKSLVLHFLQQYYAIYDSGDRQGLLDAYHDGACCSLSIPFIPQNPARSSLAEYFKDSRNVKKLKDPTLRFRLLKHTRLNVVAFLNELPKTQHDVNSFVVDISAQTSTLLCFSVNGVFKEVDGKSRDSLRAFTRTFIAVPASNSGLCIVNDELFVRNASSEEIQRAFAMPAPTPSSSPVPTLSPEQQEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTHLKAKGEIPEVAFMK
uniprot
proteins
function
FUNCTION: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:9660949}.
uniprot
proteins
mass_dalton
70182
uniprot
proteins
mutagenesis
MUTAGEN 71; /note="R->A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-78, A-81, A-82, A-89, A-91, A-97, A-98, A-100 and A-105."; /evidence="ECO:0000269|PubMed:18364396"; MUTAGEN 78; /note="R->A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-81, A-82, A-89, A-91, A-97, A-98, A-100 and A-105."; /evidence="ECO:0000269|PubMed:18364396"; MUTAGEN 81; /note="R->A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-78, A-82, A-89, A-91, A-97, A-98, A-100 and A-105."; /evidence="ECO:0000269|PubMed:18364396"; MUTAGEN 82; /note="R->A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-78, A-81, A-89, A-91, A-97, A-98, A-100 and A-105."; /evidence="ECO:0000269|PubMed:18364396"; MUTAGEN 89; /note="R->A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-78, A-81, A-82, A-91, A-97, A-98, A-100 and A-105."; /evidence="ECO:0000269|PubMed:18364396"; MUTAGEN 91; /note="R->A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-78, A-81, A-82, A-89, A-97, A-98, A-100 and A-105."; /evidence="ECO:0000269|PubMed:18364396"; MUTAGEN 97; /note="R->A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-78, A-81, A-82, A-89, A-91, A-98, A-100 and A-105."; /evidence="ECO:0000269|PubMed:18364396"; MUTAGEN 98; /note="R->A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-78, A-81, A-82, A-89, A-91, A-97, A-100 and A-105."; /evidence="ECO:0000269|PubMed:18364396"; MUTAGEN 100; /note="R->A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-78, A-81, A-82, A-89, A-91, A-97, A-98 and A-105."; /evidence="ECO:0000269|PubMed:18364396"; MUTAGEN 105; /note="R->A: Greatly reduces RNA binding and no effect on interaction with ALYREF/THOC4; when associated with A-71, A-78, A-81, A-82, A-89, A-91, A-97, A-98 and A-100."; /evidence="ECO:0000269|PubMed:18364396"; MUTAGEN 306..308; /note="ERE->AAA: Decreases the export of mRNAs from the nucleus."; MUTAGEN 383; /note="L->R: Diminishes nuclear rim staining and 80% reduction in mRNA export activity; when associated with R-386. Complete loss of nuclear rim staining and mRNA export activity; when associated with R-386 and A-594."; /evidence="ECO:0000269|PubMed:11583626"; MUTAGEN 386; /note="L->R: Diminishes nuclear rim staining and 80% reduction in mRNA export activity; when associated with R-383. Complete loss of nuclear rim staining and mRNA export activity; when associated with R-383 and A-594."; /evidence="ECO:0000269|PubMed:11583626"; MUTAGEN 399; /note="D->A: 60% reduction in mRNA export activity."; /evidence="ECO:0000269|PubMed:11583626"; MUTAGEN 450..453; /note="LRFR->AAAA: Abolishes interaction with THOC5 and CHTOP."; /evidence="ECO:0000269|PubMed:23299939"; MUTAGEN 453; /note="R->A: Impairs intramolecular interaction between RBD and NTF2."; /evidence="ECO:0000269|PubMed:22893130"; MUTAGEN 456..459; /note="KHTR->AAAA: Abolishes interaction with THOC5 and CHTOP, no effect on interaction with NXT1; enhances intramolecular interaction between RBD and NTF2, reduces RNA binding and mRNA export."; /evidence="ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23299939"; MUTAGEN 456; /note="K->D: Impairs intramolecular interaction between RBD and NTF2; when associated with D-459."; MUTAGEN 459; /note="R->D: Impairs intramolecular interaction between RBD and NTF2; when associated with D-456."; MUTAGEN 482; /note="D->R: 90% reduction in mRNA export activity."; /evidence="ECO:0000269|PubMed:11583626"; MUTAGEN 518; /note="I->R: 98% reduction in mRNA export activity."; /evidence="ECO:0000269|PubMed:11583626"; MUTAGEN 521; /note="P->Q: 35% reduction in mRNA export activity."; /evidence="ECO:0000269|PubMed:11583626"; MUTAGEN 594; /note="W->A: Suppresses FG-nucleoporin binding. Diminishes nuclear rim staining and 88% reduction in mRNA export activity. Complete loss of nuclear rim staining and mRNA export activity; when associated with R-383 and R-386."; /evidence="ECO:0000269|PubMed:11583626"; MUTAGEN 595; /note="D->R: Suppresses FG-nucleoporin binding."; MUTAGEN 617; /note="F->A: Suppresses FG-nucleoporin binding."; /evidence="ECO:0000269|PubMed:11875519
uniprot
proteins
protein_family
NXF family
uniprot
proteins
pubmed
10202158
uniprot
proteins
pubmed
10228171
uniprot
proteins
pubmed
10323864
uniprot
proteins
pubmed
10454577
uniprot
proteins
pubmed
10668806
uniprot
proteins
pubmed
10924507
uniprot
proteins
pubmed
11060011
uniprot
proteins
pubmed
11256625
uniprot
proteins
pubmed
11259411
uniprot
proteins
pubmed
11546873
uniprot
proteins
pubmed
11546874
uniprot
proteins
pubmed
11583626
uniprot
proteins
pubmed
11707413
uniprot
proteins
pubmed
11875519
uniprot
proteins
pubmed
12581645
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14729961
uniprot
proteins
pubmed
14730019
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17001072
uniprot
proteins
pubmed
18364396
uniprot
proteins
pubmed
18596238
uniprot
proteins
pubmed
18936162
uniprot
proteins
pubmed
19165146
uniprot
proteins
pubmed
19324961
uniprot
proteins
pubmed
19369354
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19586903
uniprot
proteins
pubmed
19793817
uniprot
proteins
pubmed
19836239
uniprot
proteins
pubmed
19864460
uniprot
proteins
pubmed
20005110
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21699900
uniprot
proteins
pubmed
22893130
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23299939
uniprot
proteins
pubmed
23591820
uniprot
proteins
pubmed
23826332
uniprot
proteins
pubmed
25662211
uniprot
proteins
pubmed
28984244
uniprot
proteins
pubmed
31940815
uniprot
proteins
pubmed
9175835
uniprot
proteins
pubmed
9660949
uniprot
proteins
sequence_length
619
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:25662211}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:23826332}. Nucleus speckle {ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:23826332}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:23591820}. Nucleus envelope {ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:23591820}. Cytoplasm {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:19864460}. Cytoplasm, Stress granule {ECO:0000269|PubMed:18596238}. Note=Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. The association with the TREX complex seems to occur in regions surrounding nuclear speckles known as perispeckles (PubMed:23826332). Nucleus; nuclear rim (PubMed:25662211). {ECO:0000269|PubMed:23826332, ECO:0000269|PubMed:25662211}.
uniprot
proteins