Slc5a8
entrez
216225
canonical
uniprot
Q8BYF6
canonical
ensembl
ENSMUSG00000020062
resolver
ensp
ENSMUSP00000020255
resolver
enst
ENSMUST00000020255
resolver
genesymbol
Slc5a8
resolver
genesymbol_syn
Smct
resolver
genesymbol_syn
Smct1
resolver
uniprot
Q8VD01
resolver
uniprot_entry
SC5A8_MOUSE
resolver
uniprot_sec
Q8VD01
resolver
activity_regulation
ACTIVITY REGULATION: Transport of D-lactate and pyruvate stimulated by alpha-cyano-4-hydroxycinnamic acid, but inhibited by the short-chain fatty acids acetate, propionate and butyrate. {ECO:0000269|PubMed:15322102}.
uniprot
proteins
amino_acid_sequence
MDASRDIGSFVVWDYVVFAGMLLISAAIGIYYAFAGGGQQTSKDFLMGGRSMSAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFVITYFFVVVISAEVFLPVFYRLGITSTYEYLELRFNRCIRLCGTILFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFASVIIQASITQHGINKILSDAFNGGRLNFWNFDPNPLQRHTFWTIVIGGTFTWTTIYGVNQSQVQRYISCKSRLHAKLSLYVNLVGLWVILTCSIFCGLALYSRYRECDPWTSKKVSAIDQLMPYLVLDILKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFKSLSEKSLSWISQGMSVLYGALCIGMAALASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSIGALTGLLAGFAISLWVGIGAQLYPPLPERTLPLPLETYGCNITHNGSDWMSTTEMPFSTSAFQIHNAERTPLMDNWYSLSYLYFSTIGTLTTLFVGILISLSTGGRKQNLDPRFLLTKQDFLSNFDVFKKRNHVLNYKLHPVEVGGTDNPAFNHVELNFTDHSGKINGTRL
uniprot
proteins
function
FUNCTION: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1 (PubMed:15322102, PubMed:15651982, PubMed:20211600). Catalyzes passive carrier mediated diffusion of iodide (By similarity). Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane (By similarity). May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract (By similarity). May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons (By similarity). Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline) (PubMed:20211600). Can mediate the transport of chloride, bromide, iodide and nitrate ions when external concentration of sodium ions is reduced (By similarity). Part of D-serine transport systems. May contribute to D-serine reabsorption at the brush border of renal proximal tubules thus modulating the dynamics of urinary versus blood D-serine levels. {ECO:0000250|UniProtKB:Q8N695, ECO:0000269|PubMed:15322102, ECO:0000269|PubMed:15651982, ECO:0000269|PubMed:20211600, ECO:0000305|PubMed:38650461}.
uniprot
proteins
mass_dalton
66766
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
15322102
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15651982
uniprot
proteins
pubmed
15867356
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16805814
uniprot
proteins
pubmed
17099289
uniprot
proteins
pubmed
17245649
uniprot
proteins
pubmed
20211600
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30604288
uniprot
proteins
pubmed
38650461
uniprot
proteins
sequence_length
611
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:17099289, ECO:0000269|PubMed:17245649, ECO:0000269|PubMed:30604288, ECO:0000269|PubMed:38650461}; Multi-pass membrane protein {ECO:0000255}. Note=Restricted to the apical cell membrane of enterocytes and proximal tubule epithelial cells. {ECO:0000269|PubMed:17099289, ECO:0000269|PubMed:17245649, ECO:0000269|PubMed:38650461}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 133..153; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 162..182; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 240..260; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 280..300; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 337..359; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 390..410; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 416..436; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 440..460; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 519..539; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins