NTSR1
entrez
4923
canonical
uniprot
P30989
canonical
ensembl
ENSG00000101188
resolver
ensp
ENSP00000359532
resolver
enst
ENST00000370501
resolver
genesymbol
NTSR1
resolver
genesymbol_syn
NTRR
resolver
hgnc
HGNC:8039
resolver
uniprot
Q9H4H1
resolver
uniprot
Q9H4T5
resolver
uniprot_entry
NTR1_HUMAN
resolver
uniprot_sec
Q9H4H1
resolver
uniprot_sec
Q9H4T5
resolver
amino_acid_sequence
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:21725197, PubMed:23140271, PubMed:8381365). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197). {ECO:0000269|PubMed:21725197, ECO:0000269|PubMed:23140271, ECO:0000269|PubMed:8381365}.
uniprot
proteins
mass_dalton
46259
uniprot
proteins
mutagenesis
MUTAGEN 381; /note="C->S: Abolishes palmitoylation; when associated with S-383."; /evidence="ECO:0000269|PubMed:21725197"; MUTAGEN 383; /note="C->S: Abolishes palmitoylation; when associated with S-381."; /evidence="ECO:0000269|PubMed:21725197
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:21725197}.; PTM: Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment. {ECO:0000269|PubMed:21725197}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
NTSR1 sub-subfamily
uniprot
proteins
protein_family
Neurotensin receptor subfamily
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
20048080
uniprot
proteins
pubmed
21725197
uniprot
proteins
pubmed
23140271
uniprot
proteins
pubmed
8381365
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8381365}; Multi-pass membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:21725197}. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts. {ECO:0000269|PubMed:21725197}.
uniprot
proteins
transmembrane_region
TRANSMEM 68..88; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 103..122; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 143..164; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 185..205; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 235..259; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 304..325; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 344..364; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P20789
uniprot
proteins