Grk2
entrez
25238
canonical
uniprot
P26817
canonical
ensembl
ENSRNOG00000018985
resolver
ensp
ENSRNOP00000081551
resolver
enst
ENSRNOT00000100617
resolver
genesymbol
Grk2
resolver
genesymbol_syn
Adrbk1
resolver
uniprot
A0A8I5ZSR9
resolver
uniprot_entry
A0A8I5ZSR9_RAT
resolver
uniprot_entry
GRK2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: In contrast to other AGC family kinases, the catalytic activity is solely regulated by the binding of substrates and ligands, not by phosphorylation of the kinase domain. {ECO:0000250|UniProtKB:P21146}.
uniprot
proteins
amino_acid_sequence
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFYLNHLEEAKPLVEFYEEIEKYEKLETEEERVVRSREIFDSYIMKELLACSHPFSKNATEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFHKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEIKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEDEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL
uniprot
proteins
ec_number
2.7.11.15
uniprot
proteins
ec_number
2.7.11.16
uniprot
proteins
function
FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:1403099). Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:1403099). Phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:1403099). Phosphorylates catecholamine-activated ADRB2 to regulate physiological cardiomyocyte contraction rate responses (By similarity). Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (By similarity). Key regulator of LPAR1 signaling (By similarity). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (By similarity). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). Positively regulates ciliary smoothened (SMO) signaling pathway by mediating phosphorylation of SMO, facilitating SMO trafficking into the cilium and the stimulation of SMO activity (By similarity). Also positively regulates SMO signaling by mediating phosphorylation of GPR161, a key inhibitor SMO signaling, promoting ciliary export of GPR161 (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (By similarity). Also able to mediate phosphorylation-independent desensitization of dopamine receptor DRD2 (PubMed:19815545). {ECO:0000250|UniProtKB:P21146, ECO:0000250|UniProtKB:P25098, ECO:0000250|UniProtKB:Q99MK8, ECO:0000269|PubMed:1403099, ECO:0000269|PubMed:19815545}.
uniprot
proteins
mass_dalton
79785
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
GPRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
1403099
uniprot
proteins
pubmed
1436718
uniprot
proteins
pubmed
19815545
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9826657
uniprot
proteins
sequence_length
689
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1403099}. Cell membrane {ECO:0000250|UniProtKB:P21146}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:P25098}. Postsynapse {ECO:0000269|PubMed:1403099}. Presynapse {ECO:0000269|PubMed:1403099}.
uniprot
proteins