Dync1i2
entrez
13427
canonical
uniprot
O88487
canonical
ensembl
ENSMUSG00000027012
resolver
ensp
ENSMUSP00000080410
resolver
ensp
ENSMUSP00000097605
resolver
ensp
ENSMUSP00000107764
resolver
ensp
ENSMUSP00000107766
resolver
ensp
ENSMUSP00000107767
resolver
ensp
ENSMUSP00000107768
resolver
ensp
ENSMUSP00000107770
resolver
ensp
ENSMUSP00000107772
resolver
ensp
ENSMUSP00000192002
resolver
ensp
ENSMUSP00000192012
resolver
ensp
ENSMUSP00000192020
resolver
ensp
ENSMUSP00000192030
resolver
enst
ENSMUST00000081710
resolver
enst
ENSMUST00000100028
resolver
enst
ENSMUST00000112136
resolver
enst
ENSMUST00000112138
resolver
enst
ENSMUST00000112139
resolver
enst
ENSMUST00000112140
resolver
enst
ENSMUST00000112142
resolver
enst
ENSMUST00000112144
resolver
genesymbol
Dync1i2
resolver
genesymbol_syn
Dnci2
resolver
genesymbol_syn
Dncic2
resolver
uniprot
A2BFF5
resolver
uniprot
A2BFF7
resolver
uniprot
A2BFF8
resolver
uniprot
A2BFF9
resolver
uniprot
D6Q0F5
resolver
uniprot
D6Q0F6
resolver
uniprot
D6Q0F7
resolver
uniprot
F6QPM1
resolver
uniprot
Q3TGH7
resolver
uniprot
Q3TPJ8
resolver
uniprot_entry
A2BFF5_MOUSE
resolver
uniprot_entry
A2BFF7_MOUSE
resolver
uniprot_entry
A2BFF8_MOUSE
resolver
uniprot_entry
A2BFF9_MOUSE
resolver
uniprot_entry
D6Q0F5_MOUSE
resolver
uniprot_entry
D6Q0F6_MOUSE
resolver
uniprot_entry
D6Q0F7_MOUSE
resolver
uniprot_entry
DC1I2_MOUSE
resolver
uniprot_entry
F6QPM1_MOUSE
resolver
uniprot_entry
Q3TPJ8_MOUSE
resolver
uniprot_sec
Q3TGH7
resolver
amino_acid_sequence
MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAAVSVQEESDLEKKRREAEALLQSMGLTTDSPIVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRRGPIKLGMAKITQVDFPPREIVTYTKETQTPVTAQPKEDEEEEDDVATPKPPVEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEEAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNSDYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINANRADAEEEAATRIPA
uniprot
proteins
function
FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (By similarity). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (PubMed:27474409). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (PubMed:27474409). {ECO:0000250|UniProtKB:Q62871, ECO:0000269|PubMed:27474409}.
uniprot
proteins
mass_dalton
68394
uniprot
proteins
mutagenesis
MUTAGEN 51; /note="S->A: Abolished both phosphorylation and pyrophosphorylation."; /evidence="ECO:0000269|PubMed:27474409
uniprot
proteins
post_translational_modification
PTM: The phosphorylation status of Ser-84 appears to be involved in dynactin-dependent target binding. {ECO:0000250|UniProtKB:Q62871}.; PTM: Pyrophosphorylation by 5-diphosphoinositol pentakisphosphate (5-IP7) promotes interaction with DCTN1 (PubMed:27474409). Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue (PubMed:27474409). {ECO:0000269|PubMed:27474409}.
uniprot
proteins
protein_family
Dynein intermediate chain family
uniprot
proteins
pubmed
10049579
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22956769
uniprot
proteins
pubmed
27474409
uniprot
proteins
pubmed
28619825
uniprot
proteins
pubmed
34792097
uniprot
proteins
sequence_length
612
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:28619825}. Cytoplasm {ECO:0000269|PubMed:28619825}. Note=Detected in the cytoplasm of pachytene spermatocytes. Localizes to the manchette in elongating spermatids. {ECO:0000269|PubMed:28619825}.
uniprot
proteins