ERVFC1
entrez
105373297
canonical
uniprot
P60507
canonical
ensembl
ENSG00000233887
resolver
genesymbol
ERVFC1
resolver
uniprot
Q5JTS0
resolver
uniprot_entry
EFC1_HUMAN
resolver
uniprot_sec
Q5JTS0
resolver
amino_acid_sequence
MARPSPLCLLLLLTLLTPIVPSNSLLTEPPFRWRFYLHETWTQGNRLSTVTLATVDCQPHGCQAQVTFNFTSFKSVLRGWSNPTICFVYDQTHSNCRDYWVDTNGGCPYAYCRMHVTQLHTAKKLQHTYRLTSDGRTTYFLTIPDPWDSRWVSGVTGRLYRWPTDSYPVGKLRIFLTYIRVIPQVLSNLKDQADNIKHQEEVINTLVQSHPKADMVTYDDKAEAGPFSWITLVRHGARLVNMAGLVNLSHCFLCTALSQPPLVAVPLPQAFNTSGNHTAHPSGVFSEQVPLFRDPLQPQFPFCYTTPNSSWCNQTYSGSLSNLSAPAGGYFWCNFTLTKHLNISSNNTLSRNLCLPISLVPRLTLYSEAELSSLVNPPMRQKRAVFPPLVIGVSLTSSLVASGLGTGAIVHFISSSQDLSIKLQMAIEASAESLASLQRQITSVAKVAMQNRRALDLLTADKGGTCMFLGEECCYYINESGLVETSLLTLDKIRDGLHRPSSTPNYGGGWWQSPLTTWIIPFISPILIICLLLLIAPCVLKFIKNRISEVSRVTVNQMLLHPYSRLPTSEDHYDDALTQQEAAR
uniprot
proteins
function
FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. {ECO:0000269|PubMed:14557543}.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
65248
uniprot
proteins
post_translational_modification
PTM: Specific enzymatic cleavages in vivo yield the mature SU and TM proteins. {ECO:0000250}.; PTM: The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Gamma type-C retroviral envelope protein family
uniprot
proteins
protein_family
HERV class-I F(c)1 env subfamily
uniprot
proteins
pubmed
11689652
uniprot
proteins
pubmed
12890629
uniprot
proteins
pubmed
12970426
uniprot
proteins
pubmed
14557543
uniprot
proteins
pubmed
15772651
uniprot
proteins
sequence_length
584
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Virion.; SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 519..539; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins