CRMP1
entrez
1400
canonical
uniprot
Q14194
canonical
ensembl
ENSG00000072832
resolver
ensp
ENSP00000321606
resolver
ensp
ENSP00000380987
resolver
ensp
ENSP00000425742
resolver
enst
ENST00000512574
resolver
genesymbol
CRMP1
resolver
genesymbol_syn
DPYSL1
resolver
genesymbol_syn
ULIP3
resolver
hgnc
HGNC:2365
resolver
uniprot
A0EJG6
resolver
uniprot
B3KT07
resolver
uniprot
B3KV96
resolver
uniprot
E9PD68
resolver
uniprot
Q13024
resolver
uniprot
Q4W5F1
resolver
uniprot
Q96I11
resolver
uniprot
Q96TC8
resolver
uniprot
X5DNI1
resolver
uniprot_entry
B3KT07_HUMAN
resolver
uniprot_entry
B3KV96_HUMAN
resolver
uniprot_entry
DPYL1_HUMAN
resolver
uniprot_entry
E9PD68_HUMAN
resolver
uniprot_entry
Q96I11_HUMAN
resolver
uniprot_entry
X5DNI1_HUMAN
resolver
uniprot_sec
A0EJG6
resolver
uniprot_sec
Q13024
resolver
uniprot_sec
Q4W5F1
resolver
uniprot_sec
Q96TC8
resolver
amino_acid_sequence
MSYQGKKSIPHITSDRLLIKGGRIINDDQSLYADVYLEDGLIKQIGENLIVPGGVKTIEANGRMVIPGGIDVNTYLQKPSQGMTAADDFFQGTRAALVGGTTMIIDHVVPEPGSSLLTSFEKWHEAADTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVNSFQVYMAYKDVYQMSDSQLYEAFTFLKGLGAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAITIAGRINCPVYITKVMSKSAADIIALARKKGPLVFGEPIAASLGTDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYLTSLLACGDLQVTGSGHCPYSTAQKAVGKDNFTLIPEGVNGIEERMTVVWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKLKTITAKSHKSAVEYNIFEGMECHGSPLVVISQGKIVFEDGNINVNKGMGRFIPRKAFPEHLYQRVKIRNKVFGLQGVSRGMYDGPVYEVPATPKYATPAPSAKSSPSKHQPPPIRNLHQSNFSLSGAQIDDNNPRRTGHRIVAPPGGRSNITSLG
uniprot
proteins
function
FUNCTION: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413). {ECO:0000269|PubMed:11562390, ECO:0000269|PubMed:19799413, ECO:0000269|PubMed:25358863}.
uniprot
proteins
mass_dalton
62184
uniprot
proteins
mutagenesis
MUTAGEN 101..102; /note="TT->AA: 2.5-fold increase in cells with a defect of cytokinesis."; /evidence="ECO:0000269|PubMed:19799413
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-522 enhances CRMP1-mediated alteration of FLNA ternary structure and FLNA dissociation from F-actin. {ECO:0000269|PubMed:25358863}.
uniprot
proteins
protein_family
Hydantoinase/dihydropyrimidinase family
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
pubmed
10048489
uniprot
proteins
pubmed
11562390
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19362386
uniprot
proteins
pubmed
19799413
uniprot
proteins
pubmed
25358863
uniprot
proteins
pubmed
26249678
uniprot
proteins
pubmed
7637782
uniprot
proteins
pubmed
8973361
uniprot
proteins
pubmed
9375656
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11562390}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11562390}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11562390}. Cell projection, growth cone {ECO:0000250|UniProtKB:P97427}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P97427}. Perikaryon {ECO:0000250|UniProtKB:P97427}. Note=Associated with centrosomes and the mitotic spindle during metaphase (PubMed:11562390). Colocalizes with FLNA and tubulin in the central region of DRG neuron growth cone (By similarity). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity). {ECO:0000250|UniProtKB:P97427, ECO:0000269|PubMed:11562390}.
uniprot
proteins