ABCC1
entrez
4363
canonical
uniprot
P33527
canonical
ensembl
ENSG00000103222
resolver
ensembl
ENSG00000278183
resolver
ensp
ENSP00000382342
resolver
ensp
ENSP00000461615
resolver
ensp
ENSP00000502873
resolver
ensp
ENSP00000584197
resolver
ensp
ENSP00000584198
resolver
ensp
ENSP00000584199
resolver
ensp
ENSP00000584200
resolver
ensp
ENSP00000584201
resolver
ensp
ENSP00000584202
resolver
ensp
ENSP00000584203
resolver
ensp
ENSP00000584205
resolver
ensp
ENSP00000584206
resolver
ensp
ENSP00000584207
resolver
ensp
ENSP00000584208
resolver
ensp
ENSP00000584213
resolver
enst
ENST00000677164
resolver
genesymbol
ABCC1
resolver
genesymbol_syn
MRP
resolver
genesymbol_syn
MRP1
resolver
hgnc
HGNC:51
resolver
uniprot
A0A7I2V2E0
resolver
uniprot
A3RJX2
resolver
uniprot
C9JPJ4
resolver
uniprot
O14819
resolver
uniprot
O43333
resolver
uniprot
P78419
resolver
uniprot
Q59GI9
resolver
uniprot
Q9UQ97
resolver
uniprot
Q9UQ99
resolver
uniprot
Q9UQA0
resolver
uniprot_entry
A0A7I2V2E0_HUMAN
resolver
uniprot_entry
MRP1_HUMAN
resolver
uniprot_sec
A3RJX2
resolver
uniprot_sec
C9JPJ4
resolver
uniprot_sec
O14819
resolver
uniprot_sec
O43333
resolver
uniprot_sec
P78419
resolver
uniprot_sec
Q59GI9
resolver
uniprot_sec
Q9UQ97
resolver
uniprot_sec
Q9UQ99
resolver
uniprot_sec
Q9UQA0
resolver
activity_regulation
ACTIVITY REGULATION: MK 571 inhibits sphingosine 1-phosphate and leukotriene C4 export. {ECO:0000269|PubMed:17050692, ECO:0000269|PubMed:7961706}.
uniprot
proteins
amino_acid_sequence
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
uniprot
proteins
disease_involvement
DISEASE: Deafness, autosomal dominant, 77 (DFNA77) [MIM:618915]: A form of non-syndromic deafness characterized by adult onset of bilateral, postlingual, mild-to-severe sensorineural hearing loss. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269|PubMed:31273342}. Note=The gene represented in this entry is involved in disease pathogenesis.
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
ec_number
7.6.2.3
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable the active transport of organic anions conjugated with glutathione, glucuronate or sulfate. Operates at the plasma membrane where it mediates the efflux of substrates from the cytoplasm into the extracellular space. The rate of transport is in some way coupled to the reduced glutathione (GSH) intracellular levels (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:8640791, PubMed:7961706, PubMed:9281595). Mediates the systemic release of glutathione-conjugated leukotriene C4 (LTC4) from myeloid cells such as mast cells, as part of the inflammatory response (PubMed:10064732, PubMed:11114332, PubMed:7961706, PubMed:8640791). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231). Can export both GSH and its oxidized form GSSG in a protective mechanism that limits cellular damage especially during oxidative stress. Regulates GSH and GSSG release from astrocytes to maintain glutathione redox equilibrium in the brain (PubMed:16230346, PubMed:8640791). Transports signaling molecules. Appears to selectively recognize cyclic 2'3'-GMP-AMP (cGAMP) produced by mammals but not 3'3'-cGAMP produced by bacteria. Mediates 2'3'-cGAMP export and limits intracellular cGAMP-mediated cGAS-STING signaling and type I interferon synthesis (PubMed:36070769, PubMed:39765229). Exports sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Confers resistance to anticancer drugs by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Similarly to MRP2, transports various steroids, bile acids and bilirubin conjugates (PubMed:8640791, PubMed:9355767). {ECO:0000250|UniProtKB:O35379, ECO:0000269|PubMed:10064732, ECO:0000269|PubMed:11114332, ECO:0000269|PubMed:16230346, ECO:0000269|PubMed:17050692, ECO:0000269|PubMed:36070769, ECO:0000269|PubMed:39765229, ECO:0000269|PubMed:7961706, ECO:0000269|PubMed:8640791, ECO:0000269|PubMed:9281595, ECO:0000269|PubMed:9355767, ECO:0000269|PubMed:9426231}.
uniprot
proteins
mass_dalton
171591
uniprot
proteins
mutagenesis
MUTAGEN 7; /note="C->S: Does not affect protein expression or localization at the cell surface; when associated with S-32. Has no significant effect on 2'3'-cGAMP transport; when associated with S-32."; /evidence="ECO:0000269|PubMed:39765229"; MUTAGEN 32; /note="C->S: Does not affect protein expression or localization at the cell surface; when associated with S-7. Has no significant effect on 2'3'-cGAMP transport; when associated with S-7."; /evidence="ECO:0000269|PubMed:39765229"; MUTAGEN 440; /note="Y->A: Has no significant effect on protein expression or 2'3'-cGAMP transport."; /evidence="ECO:0000269|PubMed:39765229"; MUTAGEN 580; /note="Q->A: No effect."; /evidence="ECO:0000269|PubMed:15260484"; MUTAGEN 581; /note="T->A: No effect."; /evidence="ECO:0000269|PubMed:15260484"; MUTAGEN 585; /note="S->A: No effect."; /evidence="ECO:0000269|PubMed:15260484"; MUTAGEN 597; /note="N->A: Increases resistance to vincristine and decreases resistance to VP-16."; /evidence="ECO:0000269|PubMed:15260484"; MUTAGEN 604; /note="S->A: Increases estradiol glucuronide transport."; /evidence="ECO:0000269|PubMed:15260484"; MUTAGEN 605; /note="S->A: Decreases resistance to vincristine, VP-16 and doxorubicin."; /evidence="ECO:0000269|PubMed:15260484"; MUTAGEN 792; /note="D->A: Only partially affects protein maturation; impairs leukotriene C4 transport."; /evidence="ECO:0000269|PubMed:11469806"; MUTAGEN 792; /note="D->L: Impairs protein maturation and leukotriene C4 transport."; /evidence="ECO:0000269|PubMed:11469806"; MUTAGEN 793; /note="D->L: No effect on protein maturation and leukotriene C4 transport."; /evidence="ECO:0000269|PubMed:11469806"; MUTAGEN 1046; /note="R->D: Slightly impairs leukotriene C4 and estradiol glucuronide transport."; /evidence="ECO:0000269|PubMed:15208328"; MUTAGEN 1084; /note="D->R: Impairs leukotriene C4 and estradiol glucuronide transport."; /evidence="ECO:0000269|PubMed:15208328"; MUTAGEN 1089; /note="E->A,L,N,Q: Decreases resistance to anthracyclines."; /evidence="ECO:0000269|PubMed:11278596"; MUTAGEN 1089; /note="E->D: No effect."; /evidence="ECO:0000269|PubMed:11278596"; MUTAGEN 1089; /note="E->K: Abolishes resistance to anthracyclines."; /evidence="ECO:0000269|PubMed:11278596"; MUTAGEN 1120; /note="P->A: Decreases 2'3'-cGAMP efflux."; /evidence="ECO:0000269|PubMed:39765229"; MUTAGEN 1120; /note="P->F: Impairs dimerization leading to decreased 2'3'-cGAMP-stimulated ATPase activity and decreased 2'3'-cGAMP efflux. Does not affect protein expression or localization at the cell surface."; /evidence="ECO:0000269|PubMed:39765229"; MUTAGEN 1131; /note="R->E: Slightly impairs leukotriene C4 and estradiol glucuronide transport."; /evidence="ECO:0000269|PubMed:15208328"; MUTAGEN 1138; /note="R->E,K: Strongly reduced transport of leukotriene C4, estradiol glucuronide and of glutathione."; /evidence="ECO:0000269|PubMed:16230346"; MUTAGEN 1141; /note="K->E: Reduced transport of leukotriene C4 and of glutathione."; /evidence="ECO:0000269|PubMed:16230346"; MUTAGEN 1141; /note="K->R: Reduced transport of glutathione."; /evidence="ECO:0000269|PubMed:16230346"; MUTAGEN 1142; /note="R->E,K: Reduced transport of leukotriene C4, estradiol glucuronide and of glutathione."; /evidence="ECO:0000269|PubMed:16230346"; MUTAGEN 1197; /note="R->E: Impairs 2'3'-cGAMP-stimulated ATPase activity and 2'3'-cGAMP efflux resulting in increased IFNB expression. Does not affect protein expression or localization at the cell surface; when associated with E-1249."; /evidence="ECO:0000269|PubMed:39765229"; MUTAGEN 1242; /note="T->A: Has no significant effect on protein expression or 2'3'-cGAMP transport."; /evidence="ECO:0000269|PubMed:39765229"; MUTAGEN 1245; /note="N->A: Has no significant effect on protein expression or 2'3'-cGAMP transport."; /evidence="ECO:0000269|PubMed:39765229"; MUTAGEN 1246; /note="W->A,F,Y: Impairs estradiol glucuronide transport."; /evidence="ECO:0000269|PubMed:11278867"; MUTAGEN 1246; /note="W->C: Impairs estradiol glucuronide transport; loss of resistance to alkaloid vincristine, cationic anthracyclines, epipodophyllotoxin VP-16, but not potassium antimony tartrate; partial loss of resistance to sodium arsenite."; /evidence="ECO:0000269|PubMed:11278867"; MUTAGEN 1249; /note="R->E: Impairs 2'3'-cGAMP-stimulated ATPase activity and 2'3'-cGAMP efflux resulting in increased IFNB expression. Does not affect protein expression or localization at the cell surface; when associated with E-1197."; /evidence="ECO:0000269|PubMed:39765229"; MUTAGEN 1333; /note="K->L: Impairs leukotriene C4 transport."; /evidence="ECO:0000269|PubMed:11469806"; MUTAGEN 1333; /note="K->M: Reduced cGAMP export."; /evidence="ECO:0000269|PubMed:36070769"; MUTAGEN 1454..1455; /note="DE->LL: Impairs leukotriene C4 transport."; /evidence="ECO:0000269|PubMed:11469806"; MUTAGEN 1455; /note="E->Q: Abolishes 2'3'-cGAMP efflux."; /evidence="ECO:0000269|PubMed:39765229
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCC family
uniprot
proteins
protein_family
Conjugate transporter (TC 3.A.1.208) subfamily
uniprot
proteins
pubmed
10064732
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
10811882
uniprot
proteins
pubmed
10835642
uniprot
proteins
pubmed
11114332
uniprot
proteins
pubmed
11139250
uniprot
proteins
pubmed
11266082
uniprot
proteins
pubmed
11278596
uniprot
proteins
pubmed
11278867
uniprot
proteins
pubmed
11469806
uniprot
proteins
pubmed
11721885
uniprot
proteins
pubmed
1360704
uniprot
proteins
pubmed
15208328
uniprot
proteins
pubmed
15260484
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16230346
uniprot
proteins
pubmed
16697012
uniprot
proteins
pubmed
17050692
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18987736
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23580527
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
31273342
uniprot
proteins
pubmed
36070769
uniprot
proteins
pubmed
39765229
uniprot
proteins
pubmed
7961706
uniprot
proteins
pubmed
8098549
uniprot
proteins
pubmed
8640791
uniprot
proteins
pubmed
9281595
uniprot
proteins
pubmed
9295302
uniprot
proteins
pubmed
9334225
uniprot
proteins
pubmed
9344662
uniprot
proteins
pubmed
9355767
uniprot
proteins
pubmed
9426231
uniprot
proteins
pubmed
9485377
uniprot
proteins
sequence_length
1531
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16230346, ECO:0000269|PubMed:31273342, ECO:0000269|PubMed:39765229}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:9426231}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..50; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4"; TRANSMEM 76..90; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4"; TRANSMEM 107..120; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4"; TRANSMEM 137..150; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4"; TRANSMEM 173..188; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4"; TRANSMEM 329..342; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4"; TRANSMEM 367..381; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4"; TRANSMEM 443..456; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4"; TRANSMEM 469..484; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4"; TRANSMEM 545..560; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4"; TRANSMEM 586..599; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4"; TRANSMEM 973..989; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4"; TRANSMEM 1023..1038; /note="Helical; Name=13"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4"; TRANSMEM 1092..1108; /note="Helical; Name=14"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4"; TRANSMEM 1114..1126; /note="Helical; Name=15"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4"; TRANSMEM 1201..1214; /note="Helical; Name=16"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4"; TRANSMEM 1233..1246; /note="Helical; Name=17"; /evidence="ECO:0000269|PubMed:39765229, ECO:0000312|PDB:8VT4
uniprot
proteins