PRR5
entrez
55615
canonical
uniprot
P85299
canonical
ensembl
ENSG00000186654
resolver
ensp
ENSP00000006251
resolver
ensp
ENSP00000337464
resolver
ensp
ENSP00000384848
resolver
ensp
ENSP00000400925
resolver
ensp
ENSP00000479623
resolver
ensp
ENSP00000520433
resolver
genesymbol
PRR5
resolver
genesymbol_syn
PROTOR1
resolver
hgnc
HGNC:31682
resolver
uniprot
B1AHF6
resolver
uniprot
B1AHG5
resolver
uniprot
B3KP73
resolver
uniprot
O75983
resolver
uniprot
O95695
resolver
uniprot
Q5BIW2
resolver
uniprot
Q5EAJ8
resolver
uniprot
Q5EAJ9
resolver
uniprot
Q5XKJ6
resolver
uniprot
Q96RW1
resolver
uniprot
Q96RW2
resolver
uniprot
Q9HA49
resolver
uniprot
Q9HC46
resolver
uniprot
Q9NSG0
resolver
uniprot
Q9NVX8
resolver
uniprot
Q9NXL1
resolver
uniprot
Q9UH20
resolver
uniprot_entry
PRR5_HUMAN
resolver
uniprot_sec
B1AHF6
resolver
uniprot_sec
B1AHG5
resolver
uniprot_sec
B3KP73
resolver
uniprot_sec
O75983
resolver
uniprot_sec
O95695
resolver
uniprot_sec
Q5BIW2
resolver
uniprot_sec
Q5EAJ8
resolver
uniprot_sec
Q5EAJ9
resolver
uniprot_sec
Q5XKJ6
resolver
uniprot_sec
Q96RW1
resolver
uniprot_sec
Q96RW2
resolver
uniprot_sec
Q9HA49
resolver
uniprot_sec
Q9HC46
resolver
uniprot_sec
Q9NSG0
resolver
uniprot_sec
Q9NVX8
resolver
uniprot_sec
Q9NXL1
resolver
uniprot_sec
Q9UH20
resolver
amino_acid_sequence
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILEKRLLRRSRSGDVLAKNPVVRSKSYNTPLLNPVQEHEAEGAAAGGTSIRRHSVSEMTSCPEPQGFSDPPGQGPTGTFRSSPAPHSGPCPSRLYPTTQPPEQGLDPTRSSLPRSSPENLVDQILESVDSDSEGIFIDFGRGRGSGMSDLEGSGGRQSVV
uniprot
proteins
function
FUNCTION: Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:17461779, PubMed:17599906, PubMed:29424687). PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling (PubMed:17599906). May act as a tumor suppressor in breast cancer (PubMed:15718101). {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:17599906, ECO:0000269|PubMed:29424687}.
uniprot
proteins
mass_dalton
42753
uniprot
proteins
protein_family
PROTOR family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
15718101
uniprot
proteins
pubmed
17461779
uniprot
proteins
pubmed
17599906
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29424687
uniprot
proteins
sequence_length
388
uniprot
proteins