SNRPA1
entrez
6627
canonical
uniprot
P09661
canonical
ensembl
ENSG00000131876
resolver
ensp
ENSP00000254193
resolver
enst
ENST00000254193
resolver
genesymbol
SNRPA1
resolver
hgnc
HGNC:11152
resolver
uniprot
B2R5I6
resolver
uniprot
Q8TBD2
resolver
uniprot_entry
RU2A_HUMAN
resolver
uniprot_sec
B2R5I6
resolver
uniprot_sec
Q8TBD2
resolver
amino_acid_sequence
MVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVKLKERQEAEKMFKGKRGAQLAKDIARRSKTFNPGAGLPTDKKKGGPSPGDVEAIKNAIANASTLAEVERLKGLLQSGQIPGRERRSGPTDDGEEEMEEDTVTNGS
uniprot
proteins
function
FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:27035939, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:27035939, PubMed:32494006, PubMed:9716128). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:27035939, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:9716128}.
uniprot
proteins
mass_dalton
28416
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="Y->D: Results in defective spliceosome assembly."; /evidence="ECO:0000269|PubMed:27035939"; MUTAGEN 27; /note="R->Q: No change in spliceosome assembly."; /evidence="ECO:0000269|PubMed:27035939"; MUTAGEN 68; /note="T->K: No change in spliceosome assembly."; /evidence="ECO:0000269|PubMed:27035939"; MUTAGEN 72; /note="N->K: No change in spliceosome assembly."; /evidence="ECO:0000269|PubMed:27035939"; MUTAGEN 73; /note="N->K: No change in spliceosome assembly."; /evidence="ECO:0000269|PubMed:27035939"; MUTAGEN 92; /note="E->V: Results in defective spliceosome assembly."; /evidence="ECO:0000269|PubMed:27035939"; MUTAGEN 148; /note="Q->R: Results in defective spliceosome assembly."; /evidence="ECO:0000269|PubMed:27035939
uniprot
proteins
protein_family
U2 small nuclear ribonucleoprotein A family
uniprot
proteins
pubmed
10339552
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27035939
uniprot
proteins
pubmed
28076346
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28502770
uniprot
proteins
pubmed
28781166
uniprot
proteins
pubmed
2928112
uniprot
proteins
pubmed
32494006
uniprot
proteins
pubmed
36797247
uniprot
proteins
pubmed
9531537
uniprot
proteins
pubmed
9716128
uniprot
proteins
sequence_length
255
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}.
uniprot
proteins