Asxl1
entrez
228790
canonical
uniprot
P59598
canonical
ensembl
ENSMUSG00000042548
resolver
ensp
ENSMUSP00000105413
resolver
enst
ENSMUST00000109790
resolver
genesymbol
Asxl1
resolver
genesymbol_syn
Kiaa0978
resolver
uniprot
Q24JP2
resolver
uniprot_entry
ASXL1_MOUSE
resolver
uniprot_entry
Q24JP2_MOUSE
resolver
amino_acid_sequence
MKDKQKRKKERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKKDAVQWSRNAATVDGDEPEDSADVESCGSNEASTVSGENDVSLDETSSNASCSTESQSRPLSNPRDSHRASSQANKQKKRTGVMLPRVVLTPLKVNGAHVEPASGFSGRHADGESGSPSSSSSGSLALGNSAIRGQAEVTRDPAPLLRGFRKPATGQMKRNRGEEVDFETPGSILVNTNLRALINSRTFHALPLHFQQQLLLLLPEVDRQVGTDGLLRLSGSALNNEFFTHAAQSWRERLADGEFTHEMQVRLRQEMEKEKKVEQWKEKFFEDYYGQKLGLTKEESLQQKEVQEEAKVKSGLCVSGESVRPQRGPNTRQRDGHFKKRSRPDLRTRSRRNIYKKQEPEQAGVAKDASAAPDVSLSKDTKTDLAGVNSTPGPDVSSATSGQEGPKCPSEPVASQIQAERDNLACASASPDRIPTLPQDTVDQETKDQKRKSFEQEASASFPEKKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPWVAKGRPTYQICPRIVPITESSCRGWTGARTLADIKARALQARGARGYHCNRETATTAIGGGGGPGGGGSGAIDEGGGRDSSSGDGSEACGHPEPRGAPSTSGESASDLQRTQLLPPCPLNGEHTPAEAAMPRARREDSASLRKEESCLLKRVPGVLTSGLEDASQPPIAPTGDQPCQALPPLSSQTPVAEMLTEQPKLLLDDRTECESSREDQGPTIPSESSSGRFPLGDLLGGGSDQAFDNMKEPVSMTPTFISELSLANYLQDRPDDDGLGLGATGLLIRESSRQEALTEAFASGSPTSWVPILSNYEVIKTSDPESRENIPCPEPQDEKEWERAVPLIAATESVPQPESCISHWTPPPAAVGSTGSDSEQVDLERLEMNGISEAPSPHSESTDTASDSEGHLSEDSSEVDASEVTVVKGSLGGDEKQDWDPSASLSKVNNDLSVLTRTGGVAASQSWVSRVCSVPHKIPDSLLLSSTECQPRSVCPLRPGSSVEVTNPLVMHLLHGNLPLEKVLPPGHRSSRLESSQLPLREQSQDRGTLQGTGENNRLAARINPGSAQTLKESILAQSYGASAGLVRAMASKAPAMSQKIAKMVTSLDSQHPETELTPSSGNLEEIDSKEHLSSFLCEEQKEGHSLSQGSDPGAAPGQCLGDHTTSKVPCFSSTNVSLSFGSEQTDGTLSDQNNAGGHEKKLFGPGNTVTTLQCPRSEEQTPLPAEVPPVFPSRKIEPSKNSVSGGVQTTRENRMPKPPPVSADSIKTEQTFLRDPIKADAENRKAAGYSSLELVGHLQGMPFVVDLPFWKLPREPGKGFSQPLEPSSIPSQLNIKQALYGKLSKLQLSPTSFNYSSSSATFPKGLAGGVVQLSHKASFGTGHTASLSLQMFADSSAVESISLQCACSLKAMIMCQGCGAFCHDDCIGPSKLCVLCLVVR
uniprot
proteins
function
FUNCTION: Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as a coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (PubMed:21047783). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity). Acts as a sensor of N(6)-methyladenine methylation on DNA (6mA): recognizes and binds 6mA DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (By similarity). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (By similarity). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:32747411). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (PubMed:32747411). ASXL1 and ASXL2 are important for BAP1 protein stability (By similarity). Together with BAP1, negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000250|UniProtKB:Q8IXJ9, ECO:0000269|PubMed:16606617, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:32747411, ECO:0000269|PubMed:34170818}.
uniprot
proteins
mass_dalton
162674
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by TRIP12, leading to its subsequent degradation following binding of N(6)-methyladenine methylated DNA (6mA). {ECO:0000250|UniProtKB:Q8IXJ9}.
uniprot
proteins
protein_family
Asx family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
16606617
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19880879
uniprot
proteins
pubmed
21047783
uniprot
proteins
pubmed
25750265
uniprot
proteins
pubmed
32747411
uniprot
proteins
pubmed
34170818
uniprot
proteins
sequence_length
1514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins