Atp6v1g1
entrez
66290
canonical
uniprot
Q9CR51
canonical
ensembl
ENSMUSG00000039105
resolver
ensp
ENSMUSP00000048770
resolver
enst
ENSMUST00000035301
resolver
genesymbol
Atp6v1g1
resolver
genesymbol_syn
Atp6g1
resolver
uniprot
Q5HZY7
resolver
uniprot_entry
Q5HZY7_MOUSE
resolver
uniprot_entry
VATG1_MOUSE
resolver
amino_acid_sequence
MASQSQGIQQLLQAEKRAAEKVSEARKRKNRRLKQAKEEAQAEIEQYRLQREKEFKAKEAAALGSHGSCSSEVEKETREKMTVLQNYFEQNRDEVLDNLLAFVCDIRPEIHENYRING
uniprot
proteins
function
FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment. The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. {ECO:0000250|UniProtKB:O75348}.
uniprot
proteins
mass_dalton
13724
uniprot
proteins
protein_family
V-ATPase G subunit family
uniprot
proteins
pubmed
12527205
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29993276
uniprot
proteins
sequence_length
118
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:29993276}.
uniprot
proteins