CLEC4A
entrez
50856
canonical
uniprot
Q9UMR7
canonical
ensembl
ENSG00000111729
resolver
ensp
ENSP00000229332
resolver
ensp
ENSP00000247243
resolver
ensp
ENSP00000344646
resolver
ensp
ENSP00000353690
resolver
genesymbol
CLEC4A
resolver
genesymbol_syn
CLECSF6
resolver
genesymbol_syn
DCIR
resolver
genesymbol_syn
LLIR
resolver
hgnc
HGNC:13257
resolver
uniprot
Q17R69
resolver
uniprot
Q8WXW9
resolver
uniprot
Q9H2Z9
resolver
uniprot
Q9NS33
resolver
uniprot
Q9UI34
resolver
uniprot_entry
CLC4A_HUMAN
resolver
uniprot_sec
Q17R69
resolver
uniprot_sec
Q8WXW9
resolver
uniprot_sec
Q9H2Z9
resolver
uniprot_sec
Q9NS33
resolver
uniprot_sec
Q9UI34
resolver
amino_acid_sequence
MTSEITYAEVRFKNEFKSSGINTASSAASKERTAPHKSNTGFPKLLCASLLIFFLLLAISFFIAFVIFFQKYSQLLEKKTTKELVHTTLECVKKNMPVEETAWSCCPKNWKSFSSNCYFISTESASWQDSEKDCARMEAHLLVINTQEEQDFIFQNLQEESAYFVGLSDPEGQRHWQWVDQTPYNESSTFWHPREPSDPNERCVVLNFRKSPKRWGWNDVNCLGPQRSVCEMMKIHL
uniprot
proteins
function
FUNCTION: C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner (PubMed:27015765). Involved in regulating immune reactivity (PubMed:10438934, PubMed:18258799). Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13 (PubMed:18258799, PubMed:20530286). In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production (PubMed:18258799). May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation (PubMed:10438934). {ECO:0000269|PubMed:10438934, ECO:0000269|PubMed:18258799, ECO:0000269|PubMed:20530286, ECO:0000269|PubMed:27015765}.; FUNCTION: (Microbial infection) Involved in the interaction between HIV-1 virus and dendritic cells. Enhances HIV-1 binding/entry and virus infection. Requires ITIM motif-associated signal transduction pathway involving phosphatases PTPN6 and PTPN11, SYK, Src kinases and MAP kinases. {ECO:0000269|PubMed:21536857}.
uniprot
proteins
mass_dalton
27512
uniprot
proteins
mutagenesis
MUTAGEN 6; /note="T->F: Decreases HIV-1 binding/entry in cells as well as virus replication."; /evidence="ECO:0000269|PubMed:21536857"; MUTAGEN 7; /note="Y->F: Decreases HIV-1 binding/entry in cells as well as virus replication."; /evidence="ECO:0000269|PubMed:21536857
uniprot
proteins
pubmed
10438934
uniprot
proteins
pubmed
11178971
uniprot
proteins
pubmed
11994513
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
18258799
uniprot
proteins
pubmed
20530286
uniprot
proteins
pubmed
21536857
uniprot
proteins
pubmed
27015765
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18258799}; Single-pass type II membrane protein {ECO:0000305}; Extracellular side {ECO:0000269|PubMed:18258799}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins