P31388
uniprot
P31388
canonical
amino_acid_sequence
MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:7680751). Also has a high affinity for tricyclic psychotropic drugs (PubMed:7680751). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of mTOR signaling (By similarity). {ECO:0000250|UniProtKB:P50406, ECO:0000250|UniProtKB:Q9R1C8, ECO:0000269|PubMed:7680751}.
uniprot
proteins
mass_dalton
46923
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
7680751
uniprot
proteins
pubmed
8389146
uniprot
proteins
sequence_length
436
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P50406}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..52; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P50406"; TRANSMEM 63..88; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P50406"; TRANSMEM 97..122; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P50406"; TRANSMEM 143..167; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P50406"; TRANSMEM 186..209; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P50406"; TRANSMEM 267..293; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P50406"; TRANSMEM 300..323; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P50406
uniprot
proteins