Oxtr
entrez
18430
canonical
uniprot
P97926
canonical
ensembl
ENSMUSG00000049112
resolver
ensp
ENSMUSP00000051132
resolver
ensp
ENSMUSP00000145300
resolver
ensp
ENSMUSP00000281531
resolver
ensp
ENSMUSP00000281535
resolver
enst
ENSMUST00000053306
resolver
enst
ENSMUST00000204027
resolver
genesymbol
Oxtr
resolver
uniprot
A0A0N4SVY6
resolver
uniprot
F8VQ78
resolver
uniprot_entry
A0A0N4SVY6_MOUSE
resolver
uniprot_entry
OXYR_MOUSE
resolver
uniprot_sec
F8VQ78
resolver
activity_regulation
ACTIVITY REGULATION: Directly inhibited by progesterone, which prevents oxytocin-binding (By similarity). Cholesterol and magnesium act as allosteric activators (By similarity). {ECO:0000250|UniProtKB:P30559, ECO:0000250|UniProtKB:P70536}.
uniprot
proteins
amino_acid_sequence
MEGTPAANWSIELDLGSGVPPGAEGNLTAGPPRRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASVPQVHIFSLREVADGVFDCWAVFIQPWGPKAYVTWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAAEGSDAAGGAGRAALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDVNAPKEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSARYLKGSRPGETSISKKSNSSTFVLSRRSSSQRSCSQPSSA
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for oxytocin (OXT), a neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection (PubMed:19369205, PubMed:25303526, PubMed:25874674, PubMed:27641503, PubMed:31843930, PubMed:38267576, PubMed:40934325). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (By similarity). OXTR is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). In presence of high levels of oxytocin, also coupled to G(i) G proteins, mediating inhibition of adenylate cyclase activity (By similarity). Central release of oxytocin plays essential roles in social behavior, such as maternal care, social cognition and affiliative behaviors, triggering signaling that modulates neural circuits by altering ion channel activity, changing intrinsic neuronal properties and modifying synaptic transmission (both excitatory and inhibitory) (PubMed:25303526, PubMed:25874674, PubMed:27641503, PubMed:38267576, PubMed:40934325). Peripheral release of oxytocin (secretion into the bloodstream) promotes various processes, such as parturition, lactation or osteoblast differentiation (PubMed:16249339, PubMed:19369205, PubMed:31843930). OXTR-mediated signaling promotes milk ejection by triggering and strengthening contraction of the smooth muscle of mammary gland (PubMed:16249339). {ECO:0000250|UniProtKB:P30559, ECO:0000269|PubMed:16249339, ECO:0000269|PubMed:19369205, ECO:0000269|PubMed:25303526, ECO:0000269|PubMed:25874674, ECO:0000269|PubMed:27641503, ECO:0000269|PubMed:31843930, ECO:0000269|PubMed:38267576, ECO:0000269|PubMed:40934325}.
uniprot
proteins
mass_dalton
42805
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-260 by PRKD1 promotes association with G(q) G protein and downstream signaling, enhancing long-term social memory (By similarity). Phosphorylated by GRK2, GRK3 and/or GRK6 following prolonged stimulation by oxytocin, promoting association with beta-arrestin (ARRB1 or ARRB2), leading to receptor desensitization and negative regulation of G protein-coupled receptor signaling (PubMed:26886170, PubMed:38883814). {ECO:0000250|UniProtKB:P30559, ECO:0000269|PubMed:26886170, ECO:0000269|PubMed:38883814}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Vasopressin/oxytocin receptor subfamily
uniprot
proteins
pubmed
16249339
uniprot
proteins
pubmed
19369205
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25303526
uniprot
proteins
pubmed
25874674
uniprot
proteins
pubmed
26886170
uniprot
proteins
pubmed
27641503
uniprot
proteins
pubmed
31843930
uniprot
proteins
pubmed
38267576
uniprot
proteins
pubmed
38883814
uniprot
proteins
pubmed
40934325
uniprot
proteins
pubmed
9027321
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P30559}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30559}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..58; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P30559"; TRANSMEM 77..102; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P30559"; TRANSMEM 109..139; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P30559"; TRANSMEM 154..174; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P30559"; TRANSMEM 200..225; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P30559"; TRANSMEM 272..295; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P30559"; TRANSMEM 308..328; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P30559
uniprot
proteins