ATF2
entrez
1386
canonical
uniprot
P15336
canonical
ensembl
ENSG00000115966
resolver
ensp
ENSP00000264110
resolver
ensp
ENSP00000340576
resolver
ensp
ENSP00000376327
resolver
ensp
ENSP00000386526
resolver
ensp
ENSP00000387093
resolver
ensp
ENSP00000407911
resolver
enst
ENST00000345739
resolver
genesymbol
ATF2
resolver
genesymbol_syn
CREB2
resolver
genesymbol_syn
CREBP1
resolver
hgnc
HGNC:784
resolver
uniprot
A1L3Z2
resolver
uniprot
A4D7U4
resolver
uniprot
A4D7U5
resolver
uniprot
A4D7V1
resolver
uniprot
A4D7V5
resolver
uniprot
D3DPE9
resolver
uniprot
G8JLM5
resolver
uniprot
Q13000
resolver
uniprot
Q3B7B7
resolver
uniprot
Q4ZFU9
resolver
uniprot
Q53RY2
resolver
uniprot
Q8TAR1
resolver
uniprot
Q96JT8
resolver
uniprot_entry
A4D7V5_HUMAN
resolver
uniprot_entry
ATF2_HUMAN
resolver
uniprot_sec
A1L3Z2
resolver
uniprot_sec
A4D7U4
resolver
uniprot_sec
A4D7U5
resolver
uniprot_sec
A4D7V1
resolver
uniprot_sec
D3DPE9
resolver
uniprot_sec
G8JLM5
resolver
uniprot_sec
Q13000
resolver
uniprot_sec
Q3B7B7
resolver
uniprot_sec
Q4ZFU9
resolver
uniprot_sec
Q53RY2
resolver
uniprot_sec
Q8TAR1
resolver
uniprot_sec
Q96JT8
resolver
amino_acid_sequence
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDSSEDISVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQMADQSTEPALSQIVMAPSSQSQPSGS
uniprot
proteins
function
FUNCTION: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response (PubMed:11932306, PubMed:15105425, PubMed:15916964, PubMed:22304920, PubMed:2529117). Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3') (PubMed:11932306, PubMed:2529117). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death (PubMed:22304920). In liver, acts as a regulator of glucose metabolism downstream of OR5V1 signaling, which promotes ATF2 activation, leading to expression of carnitine palmitoyltransferase CPT1A (By similarity). In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death (PubMed:22304920). The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF) (PubMed:15916964). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM (PubMed:18397884). Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type (PubMed:18677098). {ECO:0000250|UniProtKB:P16951, ECO:0000269|PubMed:11932306, ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920, ECO:0000269|PubMed:2529117, ECO:0000303|PubMed:18677098}.
uniprot
proteins
mass_dalton
54537
uniprot
proteins
mutagenesis
MUTAGEN 69; /note="T->A: Weak histone acetyltransferase activity."; /evidence="ECO:0000269|PubMed:10821277"; MUTAGEN 71; /note="T->A: Impairs phosphorylation by PLK3. Weak histone acetyltransferase activity."; /evidence="ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:21098032"; MUTAGEN 121; /note="S->A: Reduced phosphorylation and repression of c-Jun-mediated activation of transcription."; /evidence="ECO:0000269|PubMed:19176525
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-69 by MAPK14 and MAPK11, and at Thr-71 by MAPK1/ERK2, MAPK3/ERK1, MAPK11, MAPK12 and MAPK14 in response to external stimulus like insulin causes increased transcriptional activity (PubMed:12110590, PubMed:9430721). Phosphorylated at Thr-69 and Thr-71 by PKA, promoting transcriptional activity (By similarity). Phosphorylated by PLK3 following hyperosmotic stress (PubMed:21098032). Also phosphorylated and activated by JNK and CaMK4 (PubMed:8855261). ATM-mediated phosphorylation at Ser-490 and Ser-498 stimulates its function in DNA damage response (PubMed:15916964). Phosphorylation at Ser-62, Thr-73 and Ser-121 activates its transcriptional activity (PubMed:15105425). Phosphorylation at Thr-69 or Thr-71 enhances acetylation of histones H2B and H4 (PubMed:10821277). {ECO:0000250|UniProtKB:P16951, ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:21098032, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:9430721}.
uniprot
proteins
protein_family
ATF subfamily
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
10092462
uniprot
proteins
pubmed
10821277
uniprot
proteins
pubmed
11932306
uniprot
proteins
pubmed
12110590
uniprot
proteins
pubmed
15105425
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15916964
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17590016
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18397884
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18677098
uniprot
proteins
pubmed
19176525
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21098032
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22275354
uniprot
proteins
pubmed
22304920
uniprot
proteins
pubmed
22685333
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2320002
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2529117
uniprot
proteins
pubmed
8855261
uniprot
proteins
pubmed
9058782
uniprot
proteins
pubmed
9430721
uniprot
proteins
pubmed
9748258
uniprot
proteins
sequence_length
505
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21098032, ECO:0000269|PubMed:22275354, ECO:0000269|PubMed:22304920}. Cytoplasm {ECO:0000269|PubMed:22275354, ECO:0000269|PubMed:22304920}. Mitochondrion outer membrane {ECO:0000269|PubMed:22304920}. Note=Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization (PubMed:22275354). Localization to the cytoplasm is observed under conditions of cellular stress and in disease states (PubMed:22304920). Localizes at the mitochondrial outer membrane in response to genotoxic stress (PubMed:22304920). Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization (PubMed:22304920). Co-localizes with the MRN complex in the IR-induced foci (IRIF) (PubMed:15916964). {ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:22275354, ECO:0000269|PubMed:22304920}.
uniprot
proteins