Slc22a7
entrez
89776
canonical
uniprot
Q5RLM2
canonical
ensembl
ENSRNOG00000018420
resolver
ensembl
ENSRNOG00055007370
resolver
ensembl
ENSRNOG00060023561
resolver
ensembl
ENSRNOG00065026912
resolver
ensp
ENSRNOP00000025094
resolver
ensp
ENSRNOP00055009722
resolver
ensp
ENSRNOP00060033773
resolver
ensp
ENSRNOP00065038077
resolver
enst
ENSRNOT00000025094
resolver
enst
ENSRNOT00055012269
resolver
enst
ENSRNOT00060040836
resolver
enst
ENSRNOT00065046445
resolver
genesymbol
Slc22a7
resolver
genesymbol_syn
Nlt
resolver
genesymbol_syn
Oat2
resolver
uniprot
Q63314
resolver
uniprot_entry
S22A7_RAT
resolver
uniprot_sec
Q63314
resolver
amino_acid_sequence
MGFEDLLDKVGGFGPFQLRNLVLMALPRMLLPMHFLLPVFMAAVPAHHCALPGAPANLSHQDLWLEAHLPRETDGSFSSCLRFAYPQTVPNVTLGTEVSNSGEPEGEPLTVPCSQGWEYDRSEFSSTIATEWDLVCQQRGLNKITSTCFFIGVLVGAVVYGYLSDRFGRRRLLLVAYVSSLVLGLMSAASINYIMFVVTRTLTGSALAGFTIIVLPLELEWLDVEHRTVAGVISTVFWSGGVLLLALVGYLIRSWRWLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLLSCAKLNGRPVGEGSLSQEALNNVVTMERALQRPSYLDLFRTSQLRHISLCCMMVWFGVNFSYYGLTLDVSGLGLNVYQTQLLFGAVELPSKIMVYFLVRRLGRRLTEAGMLLGAALTFGTSLLVSLETKSWITALVVVGKAFSEAAFTTAYLFTSELYPTVLRQTGLGLTALMGRLGASLAPLAALLDGVWLLLPKVAYGGIALVAACTALLLPETKKAQLPETIQDVERKSTQEEDV
uniprot
proteins
function
FUNCTION: Functions as a Na(+)-independent bidirectional multispecific transporter (PubMed:11504818, PubMed:15900017, PubMed:21446918, PubMed:9650585). Contributes to the renal and hepatic elimination of endogenous organic compounds from the systemic circulation into the urine and bile, respectively (PubMed:25904762). Capable of transporting a wide range of purine and pyrimidine nucleobases, nucleosides, and nucleotides with cGMP, 2'deoxyguanosine and GMP being the preferred substrates (By similarity). Functions as a pH- and chloride-independent cGMP bidirectional facilitative transporter that can regulate both intracellular and extracellular levels of cGMP and may be involved in cGMP signaling pathways (By similarity). Mediates orotate/glutamate bidirectional exchange and most likely display a physiological role in hepatic release of glutamate into the blood (PubMed:21446918). Involved in renal secretion and possible reabsorption of creatinine (By similarity). Able to uptake prostaglandin E2 (PGE2) and may contribute to PGE2 renal excretion (PubMed:11504818, PubMed:9650585). Also transports alpha-ketoglutarate and urate (PubMed:9650585). Apart from the orotate/glutamate exchange, the counterions for the uptake of other SLC22A7/OAT2 substrates remain to be identified (By similarity). {ECO:0000250|UniProtKB:Q9Y694, ECO:0000269|PubMed:11504818, ECO:0000269|PubMed:15900017, ECO:0000269|PubMed:21446918, ECO:0000269|PubMed:25904762, ECO:0000269|PubMed:9650585}.
uniprot
proteins
mass_dalton
58654
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
11504818
uniprot
proteins
pubmed
15900017
uniprot
proteins
pubmed
16885152
uniprot
proteins
pubmed
21446918
uniprot
proteins
pubmed
25904762
uniprot
proteins
pubmed
8056831
uniprot
proteins
pubmed
9650585
uniprot
proteins
sequence_length
535
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:8056831}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:25904762}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q9Y694}; Multi-pass membrane protein {ECO:0000305}. Note=Located to the sinusoidal/basolateral membrane of hepatocytes (PubMed:8056831). Apical side of the renal tubule (PubMed:25904762). {ECO:0000269|PubMed:25904762, ECO:0000269|PubMed:8056831}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 178..198; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 257..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 375..395; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 402..422; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 429..449; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 464..484; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 489..509; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins