PTPRU
entrez
10076
canonical
uniprot
Q92729
canonical
ensembl
ENSG00000060656
resolver
ensp
ENSP00000334941
resolver
ensp
ENSP00000362884
resolver
ensp
ENSP00000392332
resolver
ensp
ENSP00000432906
resolver
genesymbol
PTPRU
resolver
genesymbol_syn
FMI
resolver
genesymbol_syn
PCP2
resolver
genesymbol_syn
PTPRO
resolver
hgnc
HGNC:9683
resolver
uniprot
A6H8L1
resolver
uniprot
O00197
resolver
uniprot
P78399
resolver
uniprot
Q59HA4
resolver
uniprot
Q5SYU4
resolver
uniprot
Q5SYU5
resolver
uniprot
Q92735
resolver
uniprot
Q92850
resolver
uniprot_entry
PTPRU_HUMAN
resolver
uniprot_sec
A6H8L1
resolver
uniprot_sec
O00197
resolver
uniprot_sec
P78399
resolver
uniprot_sec
Q59HA4
resolver
uniprot_sec
Q5SYU4
resolver
uniprot_sec
Q5SYU5
resolver
uniprot_sec
Q92735
resolver
uniprot_sec
Q92850
resolver
amino_acid_sequence
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGLESR
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12501215, ECO:0000269|PubMed:16574648}.
uniprot
proteins
mass_dalton
162423
uniprot
proteins
mutagenesis
MUTAGEN 1085; /note="C->S: Loss of phosphatase activity toward CTNNB1. Loss of the inhibitory effect on CTNNB1 transcriptional activity without effect on interaction with CTNNB1; when associated with S-1380."; /evidence="ECO:0000269|PubMed:12501215, ECO:0000269|PubMed:16574648"; MUTAGEN 1380; /note="C->S: No effect on phosphatase activity toward CTNNB1. Loss of the inhibitory effect on CTNNB1 transcriptional activity without effect on interaction with CTNNB1; when associated with S-1085."; /evidence="ECO:0000269|PubMed:12501215, ECO:0000269|PubMed:16574648
uniprot
proteins
post_translational_modification
PTM: The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain (By similarity). In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed. {ECO:0000250, ECO:0000269|PubMed:10397721}.; PTM: N-glycosylated. {ECO:0000269|PubMed:8700514}.; PTM: Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated. {ECO:0000269|PubMed:10397721}.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 2B subfamily
uniprot
proteins
pubmed
10395944
uniprot
proteins
pubmed
10397721
uniprot
proteins
pubmed
12501215
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16574648
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17622474
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
8700514
uniprot
proteins
pubmed
8870675
uniprot
proteins
pubmed
9070223
uniprot
proteins
pubmed
9434160
uniprot
proteins
sequence_length
1446
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction {ECO:0000269|PubMed:8700514}. Cell membrane {ECO:0000269|PubMed:8700514}; Single-pass type I membrane protein {ECO:0000269|PubMed:8700514}.
uniprot
proteins
transmembrane_region
TRANSMEM 750..770; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins