Marchf6
entrez
223455
canonical
uniprot
Q6ZQ89
canonical
ensembl
ENSMUSG00000039100
resolver
ensp
ENSMUSP00000087694
resolver
ensp
ENSMUSP00000165848
resolver
genesymbol
Marchf6
resolver
genesymbol_syn
Kiaa0597
resolver
genesymbol_syn
March6
resolver
uniprot
Q6PCS1
resolver
uniprot
Q80V02
resolver
uniprot
Q80VC7
resolver
uniprot
Q8BJA0
resolver
uniprot
Q8BXX6
resolver
uniprot_entry
MARH6_MOUSE
resolver
uniprot_sec
Q6PCS1
resolver
uniprot_sec
Q80V02
resolver
uniprot_sec
Q80VC7
resolver
uniprot_sec
Q8BJA0
resolver
uniprot_sec
Q8BXX6
resolver
amino_acid_sequence
MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFAFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAAPPFNAAGHHQNEAPVGGNGAENPAADQPANPAGENAVLGENPDAQDGQAEEEEEDNEEEDDAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHALATLVKFHRSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRIIKSLLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALLEQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQPARNNNAVPAGEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVLVAWMPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYANGIRNIDLHYIIRKLAAPVISVLLLSLCVPYVIASGAVPLLGVTAEMQNLVHRRIYPFLLMVVVLMGILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGPSTPPPVSSQE
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum membrane-associated E3 ubiquitin ligase that plays a critical role in mitigating endoplasmic reticulum stress, the regulation of cholesterol and lipid homeostasis, and ferroptosis. Acts as a pivotal component of both the Ac/N-degron pathway (targeting the N-terminal acetyl group of substrates) and the ER-associated protein degradation-cytosol (ERAD-C) pathway (targeting misfolded substrates). For instance, mediates the degradation of Ac/N-degron-bearing proteins such as the G protein regulator RGS2 and the lipid droplet protein PLIN2 (By similarity). Suppresses endoplasmic reticulum stress and ferroptosis through cytosolic POMC degradation (By similarity). Prevents ferroptosis by acting as a NADPH sensor during lipid peroxidation through its C-terminal regulatory region. Facilitates also the degradation of selected endoplasmic reticulum proteins by associating with signal peptide peptidase for the turnover of endogenous tail-anchored proteins. Promotes ubiquitination of DIO2, leading to its degradation. By ubiquitinating and thereby modulating the stability of many proteins of the cholesterol pathway including SQLE, CYP51A1, CYP11A1 and HMGCR, acts as a crucial post-translational regulator of cholesterol synthesis (By similarity). {ECO:0000250|UniProtKB:O60337}.
uniprot
proteins
mass_dalton
102273
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:O60337}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated, which results in proteasomal degradation. Deubiquitinated by USP19; protecting MARCHF6 from p97-mediated proteasomal degradation. {ECO:0000250|UniProtKB:O60337}.
uniprot
proteins
protein_family
DOA10/MARCHF6 family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
35941365
uniprot
proteins
pubmed
37421621
uniprot
proteins
sequence_length
909
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O60337}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O60337}.
uniprot
proteins
transmembrane_region
TRANSMEM 92..112; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 284..304; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 337..357; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 422..442; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 481..501; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 520..540; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 632..652; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 678..698; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 721..741; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 764..784; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 815..835; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 848..868; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins