HLA-DRA
entrez
3122
canonical
uniprot
P01903
canonical
ensembl
ENSG00000204287
resolver
ensembl
ENSG00000206308
resolver
ensembl
ENSG00000226260
resolver
ensembl
ENSG00000227993
resolver
ensembl
ENSG00000228987
resolver
ensembl
ENSG00000230726
resolver
ensembl
ENSG00000234794
resolver
ensembl
ENSG00000277263
resolver
ensp
ENSP00000372608
resolver
ensp
ENSP00000372746
resolver
ensp
ENSP00000378786
resolver
ensp
ENSP00000402951
resolver
ensp
ENSP00000404533
resolver
ensp
ENSP00000405295
resolver
ensp
ENSP00000410443
resolver
ensp
ENSP00000479287
resolver
ensp
ENSP00000540755
resolver
ensp
ENSP00000587358
resolver
enst
ENST00000383127
resolver
enst
ENST00000383259
resolver
enst
ENST00000395388
resolver
enst
ENST00000411524
resolver
enst
ENST00000414698
resolver
enst
ENST00000416883
resolver
enst
ENST00000442960
resolver
enst
ENST00000613328
resolver
enst
ENST00000870696
resolver
enst
ENST00000917299
resolver
genesymbol
HLA-DRA
resolver
genesymbol_syn
HLA-DRA1
resolver
hgnc
HGNC:4947
resolver
uniprot
A0A0G2JMH6
resolver
uniprot
A2BET4
resolver
uniprot
Q30160
resolver
uniprot
Q6IAZ1
resolver
uniprot
Q861I2
resolver
uniprot
Q9TP70
resolver
uniprot_entry
A0A0G2JMH6_HUMAN
resolver
uniprot_entry
DRA_HUMAN
resolver
uniprot_sec
A2BET4
resolver
uniprot_sec
Q30160
resolver
uniprot_sec
Q6IAZ1
resolver
uniprot_sec
Q861I2
resolver
uniprot_sec
Q9TP70
resolver
amino_acid_sequence
MAISGVPVLGFFIIAVLMSAQESWAIKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTENVVCALGLTVGLVGIIIGTIFIIKGLRKSNAAERRGPL
uniprot
proteins
function
FUNCTION: An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:15265931, PubMed:15322540, PubMed:17334368, PubMed:22327072, PubMed:24190431, PubMed:27591323, PubMed:29884618, PubMed:31495665, PubMed:8145819, PubMed:9075930). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (PubMed:17182262, PubMed:23783831). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides (PubMed:25413013). The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed:8145819). {ECO:0000269|PubMed:15265931, ECO:0000269|PubMed:15322540, ECO:0000269|PubMed:17182262, ECO:0000269|PubMed:17334368, ECO:0000269|PubMed:22327072, ECO:0000269|PubMed:23783831, ECO:0000269|PubMed:24190431, ECO:0000269|PubMed:25413013, ECO:0000269|PubMed:27591323, ECO:0000269|PubMed:29884618, ECO:0000269|PubMed:31495665, ECO:0000269|PubMed:8145819, ECO:0000269|PubMed:9075930}.
uniprot
proteins
mass_dalton
28621
uniprot
proteins
mutagenesis
MUTAGEN 65; /note="E->K: Impairs the interaction with HLA-DM complex, CLIP dissociation and peptide exchange."; /evidence="ECO:0000269|PubMed:11070170, ECO:0000269|PubMed:23260142"; MUTAGEN 68; /note="W->F: Decreases the interaction with HLA-DM complex and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 74; /note="G->S: Increases the interaction with HLA-DM complex and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 76; /note="F->A,S,V,L: Impairs the interaction with HLA-DM complex, CLIP dissociation and peptide exchange."; /evidence="ECO:0000269|PubMed:11070170, ECO:0000269|PubMed:23260142"; MUTAGEN 76; /note="F->W: Increases the interaction with HLA-DM complex and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 78; /note="S->D,H: Decreases the interaction with HLA-DM complex and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 79; /note="F->A,C: Increases the interaction with HLA-DM complex and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 80; /note="E->A: Increases the interaction with HLA-DM complex and peptide exchange. Decreases the affinity of the interaction with TCR by more than five-fold."; /evidence="ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:29884618"; MUTAGEN 82; /note="Q->A: Decreases the interaction with HLA-DM complex and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 93; /note="A->L: Decreases the affinity of the interaction with TCR by more than five-fold."; /evidence="ECO:0000269|PubMed:29884618"; MUTAGEN 115; /note="T->R: Decreases the interaction with CD4."; /evidence="ECO:0000269|PubMed:27114505"; MUTAGEN 117; /note="L->R: Decreases the interaction with CD4."; /evidence="ECO:0000269|PubMed:27114505"; MUTAGEN 121; /note="P->S: Decreases the interaction with HLA-DM complex and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 125; /note="R->A: Impairs the interaction with HLA-DM complex and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 244; /note="K->R: Almost no change in down-regulation of MHCII. No ubiquitination and complete loss of down-regulation of MHCII; when associated with 'R-254' of HLA-DRB."; /evidence="ECO:0000269|PubMed:19117940
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MARCHF1 or MARCHF8 at Lys-244 leading to down-regulation of MHCII. When associated with ubiquitination of the beta chain at 'Lys-254', the down-regulation of MHCII may be highly effective. {ECO:0000269|PubMed:19117940}.
uniprot
proteins
protein_family
MHC class II family
uniprot
proteins
pubmed
11070170
uniprot
proteins
pubmed
11080454
uniprot
proteins
pubmed
11163233
uniprot
proteins
pubmed
11432818
uniprot
proteins
pubmed
11864610
uniprot
proteins
pubmed
12244309
uniprot
proteins
pubmed
12445311
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15265931
uniprot
proteins
pubmed
15322540
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16079912
uniprot
proteins
pubmed
17182262
uniprot
proteins
pubmed
17334368
uniprot
proteins
pubmed
17583734
uniprot
proteins
pubmed
18305173
uniprot
proteins
pubmed
18697946
uniprot
proteins
pubmed
19117940
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21081917
uniprot
proteins
pubmed
21115828
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2210803
uniprot
proteins
pubmed
2212658
uniprot
proteins
pubmed
22327072
uniprot
proteins
pubmed
23260142
uniprot
proteins
pubmed
23783831
uniprot
proteins
pubmed
24190431
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25413013
uniprot
proteins
pubmed
2658055
uniprot
proteins
pubmed
27114505
uniprot
proteins
pubmed
27591323
uniprot
proteins
pubmed
29317506
uniprot
proteins
pubmed
29884618
uniprot
proteins
pubmed
31495665
uniprot
proteins
pubmed
31619516
uniprot
proteins
pubmed
32668259
uniprot
proteins
pubmed
6304715
uniprot
proteins
pubmed
6324094
uniprot
proteins
pubmed
6416803
uniprot
proteins
pubmed
6600932
uniprot
proteins
pubmed
6811954
uniprot
proteins
pubmed
6812963
uniprot
proteins
pubmed
6821129
uniprot
proteins
pubmed
6955253
uniprot
proteins
pubmed
7477400
uniprot
proteins
pubmed
7479981
uniprot
proteins
pubmed
8145819
uniprot
proteins
pubmed
8152483
uniprot
proteins
pubmed
8316295
uniprot
proteins
pubmed
9075930
uniprot
proteins
pubmed
9354468
uniprot
proteins
pubmed
9782128
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15322540, ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:29884618}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:19117940}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:19117940, ECO:0000269|PubMed:9075930}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:9075930}; Single-pass type I membrane protein {ECO:0000255}. Autolysosome membrane {ECO:0000269|PubMed:17182262}; Single-pass type I membrane protein. Note=The MHCII complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation (PubMed:18305173, PubMed:9075930). Component of immunological synapses at the interface between T cell and APC (PubMed:15322540, PubMed:29884618). {ECO:0000269|PubMed:15322540, ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:29884618, ECO:0000269|PubMed:9075930}.
uniprot
proteins
transmembrane_region
TRANSMEM 217..239; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins