Slc39a4
entrez
72027
canonical
uniprot
Q78IQ7
canonical
ensembl
ENSMUSG00000063354
resolver
ensp
ENSMUSP00000155442
resolver
ensp
ENSMUSP00000264716
resolver
genesymbol
Slc39a4
resolver
genesymbol_syn
Zip4
resolver
uniprot
Q8CHL4
resolver
uniprot_entry
S39A4_MOUSE
resolver
uniprot_sec
Q8CHL4
resolver
amino_acid_sequence
MLPKSVTQGLVLALLVGTVAVARPRNLLSLLALGQGALDRLELDGLLNTLVARVHCTDGPCEKCLSVENVLALGKPDKPQPAPESVLESRHIIYLSAAAALYLNNPEKTCKDIQAGLLASHVDDYLATLESPEAMTLGLSQLLQKIEAHAASQPTGEKTCVDLPQLLEEAEAAGVSKSAGLVLTALLDHVINGSCFQGLPSPQYFVDFVFRLHSSDPPNITLHELENLMHHLGVGGEDHSDHDDHGDHADHSHPDRKASHQDSELHTPHNSNSSVWDTLCLSAKDIMAVYGLSEEAGVSPQAWAQLTPALVQQQLSGACSPYPTIRIQDQLSQTERYLYGSLATLLICLCAVFGLLLLTCAKCSTATHYIMQTFLSLAVGALTGDALLHLIPKVLGLHTHGGEGHTHEEEVGVGGQATWRLLAVLGGFYIFFLFESFFNLLLPRDQDSEKDGPCSHGGHSHGISLQLAPSNLRQSKQTHESSRSDLVAEETPELLNPETRRLRAELRLLPYLITLGDAVHNFADGLAVGAAFSSSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVKRALLLNLASALTAFAGLYVALAVGVGEEGEAWILAVATGLFLYVALCDMLPAMMNVRDQRPWLLFLLHNVGLLGGWTVLLLLSLYEDNITF
uniprot
proteins
function
FUNCTION: Selective transporter that mediates the uptake of Zn(2+) (PubMed:12801924, PubMed:14612438, PubMed:14709598). Plays an essential role for dietary zinc uptake from small intestine (PubMed:12801924). The Zn(2+) uniporter activity is regulated by zinc availability (By similarity). Also exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (PubMed:12801924). {ECO:0000250|UniProtKB:Q6P5W5, ECO:0000269|PubMed:12801924, ECO:0000269|PubMed:14612438, ECO:0000269|PubMed:14709598}.
uniprot
proteins
mass_dalton
71063
uniprot
proteins
mutagenesis
MUTAGEN 200; /note="P->L: Reduces zinc uptake activity. Does not affect KM. Accumulated to high levels in the plasma membrane. No longer zinc responsive."; /evidence="ECO:0000269|PubMed:14709598"; MUTAGEN 340; /note="G->D: Reduces zinc uptake activity. Reduces plasma membrane localization."; /evidence="ECO:0000269|PubMed:14709598"; MUTAGEN 382; /note="L->P: Reduces zinc uptake activity. Reduces plasma membrane localization."; /evidence="ECO:0000269|PubMed:14709598"; MUTAGEN 384; /note="G->R: Reduces zinc uptake activity. Reduces plasma membrane localization."; /evidence="ECO:0000269|PubMed:14709598"; MUTAGEN 539; /note="G->R: Reduces zinc uptake activity. Accumulated to high levels in the plasma membrane. Does not affect KM. No longer zinc responsive."; /evidence="ECO:0000269|PubMed:14709598"; MUTAGEN 643; /note="G->R: Loss of zinc uptake activity. Abolishes plasma membrane localization."; /evidence="ECO:0000269|PubMed:14709598
uniprot
proteins
post_translational_modification
PTM: The extracellular N-terminal ectodomain is cleaved when cells are Zn(2+) deficient, N-terminally cleaved SLC39A4 is then internalized faster. {ECO:0000269|PubMed:18936158, ECO:0000269|PubMed:30593504}.; PTM: Under excess Zn(2+) conditions, SLC39A4 on the cell surface is rapidly endocytosed, ubiquitinated, and degraded. {ECO:0000305|PubMed:18020946}.; PTM: N-glycosylated. {ECO:0000269|PubMed:14709598}.
uniprot
proteins
protein_family
ZIP transporter (TC 2.A.5) family
uniprot
proteins
pubmed
12801924
uniprot
proteins
pubmed
14612438
uniprot
proteins
pubmed
14709598
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17483098
uniprot
proteins
pubmed
18020946
uniprot
proteins
pubmed
18936158
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22737083
uniprot
proteins
pubmed
30593504
uniprot
proteins
sequence_length
660
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14612438, ECO:0000269|PubMed:14709598, ECO:0000269|PubMed:18020946, ECO:0000269|PubMed:30593504}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A0H3LM39}. Recycling endosome membrane {ECO:0000269|PubMed:14612438}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A0H3LM39}. Apical cell membrane {ECO:0000269|PubMed:12801924, ECO:0000269|PubMed:18020946, ECO:0000269|PubMed:18936158}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A0H3LM39}. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to Zn(2+) availability. Zn(2+) deficiency promotes accumulation of SLC39A4 on the surface membrane, whereas high extracellular Zn(2+) levels induce internalization of SLC39A4, but also trigger drastic removal of cellular SLC39A4 via proteasomal and lysosomal degradation pathways (PubMed:14612438, PubMed:18020946, PubMed:30593504). Translocates to the apical membrane during zinc deficiency (PubMed:12801924, PubMed:18020946). Expressed on the apical surface of the intestinal wall (PubMed:18936158). {ECO:0000269|PubMed:12801924, ECO:0000269|PubMed:14612438, ECO:0000269|PubMed:18020946, ECO:0000269|PubMed:18936158, ECO:0000269|PubMed:30593504}.
uniprot
proteins
transmembrane_region
TRANSMEM 338..358; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:A0A0H3LM39"; TRANSMEM 377..397; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:A0A0H3LM39"; TRANSMEM 421..441; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:A0A0H3LM39"; TRANSMEM 512..531; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:A0A0H3LM39"; TRANSMEM 540..566; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:A0A0H3LM39"; TRANSMEM 572..592; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:A0A0H3LM39"; TRANSMEM 600..620; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:A0A0H3LM39"; TRANSMEM 631..651; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:A0A0H3LM39
uniprot
proteins