CDK5R1
entrez
8851
canonical
uniprot
Q15078
canonical
ensembl
ENSG00000176749
resolver
ensp
ENSP00000318486
resolver
ensp
ENSP00000547359
resolver
ensp
ENSP00000547360
resolver
ensp
ENSP00000547361
resolver
ensp
ENSP00000626269
resolver
enst
ENST00000313401
resolver
enst
ENST00000877300
resolver
enst
ENST00000877301
resolver
enst
ENST00000877302
resolver
enst
ENST00000956210
resolver
genesymbol
CDK5R1
resolver
genesymbol_syn
CDK5R
resolver
genesymbol_syn
NCK5A
resolver
hgnc
HGNC:1775
resolver
uniprot
E1P664
resolver
uniprot
Q5U0G3
resolver
uniprot
Q8N619
resolver
uniprot_entry
CD5R1_HUMAN
resolver
uniprot_entry
Q8N619_HUMAN
resolver
uniprot_sec
E1P664
resolver
uniprot_sec
Q5U0G3
resolver
amino_acid_sequence
MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR
uniprot
proteins
function
FUNCTION: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:24235147}.
uniprot
proteins
mass_dalton
34060
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Absent from the cell periphery."; /evidence="ECO:0000269|PubMed:10604467, ECO:0000269|PubMed:18507738"; MUTAGEN 8; /note="S->A: Increased susceptibility to calpain."; /evidence="ECO:0000269|PubMed:17121855"; MUTAGEN 8; /note="S->E: Reduced susceptibility to calpain."; /evidence="ECO:0000269|PubMed:17121855"; MUTAGEN 138; /note="T->A: Increased susceptibility to calpain."; /evidence="ECO:0000269|PubMed:17121855"; MUTAGEN 138; /note="T->E: Reduced susceptibility to calpain."; /evidence="ECO:0000269|PubMed:17121855"; MUTAGEN 305; /note="L->A: In L-3A mutant; abolished recognition and ubiquitination by the CRL2(FEM1B) complex."; /evidence="ECO:0000269|PubMed:33398170"; MUTAGEN 305; /note="L->R: In L-3R mutant; abolished recognition and ubiquitination by the CRL2(FEM1B) complex, while promoting recognition and ubiquitination by the CRL2(FEM1B) complex."; /evidence="ECO:0000269|PubMed:33398170
uniprot
proteins
post_translational_modification
PTM: The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10 fold shorter half-life compared to p25. The conversion results in deregulation of the CDK5 kinase: p25/CDK5 kinase displays an increased and altered tau phosphorylation in comparison to the p35/CDK5 kinase in vivo (By similarity). {ECO:0000250|UniProtKB:P61809}.; PTM: Myristoylated. A proper myristoylation signal is essential for the proper distribution of p35. {ECO:0000269|PubMed:18507738, ECO:0000269|PubMed:20213681}.; PTM: Ubiquitinated, leading to its degradation: degradation of p35 by proteasome results in down-regulation of CDK5 activity (PubMed:12393264). During this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation (PubMed:12393264). Ubiquitinated by the CRL2(FEM1B) complex, which recognizes the -Gly-Leu-Asp-Arg C-degron at the C-terminus, leading to its degradation (PubMed:33398168, PubMed:33398170). {ECO:0000269|PubMed:12393264, ECO:0000269|PubMed:33398168, ECO:0000269|PubMed:33398170}.; PTM: Phosphorylation at Ser-8 and Thr-138 by CDK5 prevents calpain-mediated proteolysis. {ECO:0000269|PubMed:17121855}.
uniprot
proteins
protein_family
Cyclin-dependent kinase 5 activator family
uniprot
proteins
pubmed
10604467
uniprot
proteins
pubmed
12393264
uniprot
proteins
pubmed
15128856
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15689152
uniprot
proteins
pubmed
16039528
uniprot
proteins
pubmed
17121855
uniprot
proteins
pubmed
17671990
uniprot
proteins
pubmed
18507738
uniprot
proteins
pubmed
20213681
uniprot
proteins
pubmed
24235147
uniprot
proteins
pubmed
33398168
uniprot
proteins
pubmed
33398170
uniprot
proteins
pubmed
8090221
uniprot
proteins
sequence_length
307
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Cyclin-dependent kinase 5 activator 1, p35]: Cell membrane {ECO:0000305|PubMed:17671990}; Lipid-anchor {ECO:0000269|PubMed:18507738}; Cytoplasmic side {ECO:0000305}. Cell projection, neuron projection {ECO:0000269|PubMed:10604467}. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals. {ECO:0000269|PubMed:10604467}.; SUBCELLULAR LOCATION: [Cyclin-dependent kinase 5 activator 1, p25]: Nucleus {ECO:0000269|PubMed:18507738}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10604467}. Perikaryon {ECO:0000269|PubMed:10604467}. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions (PubMed:18507738). In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites (PubMed:18507738). {ECO:0000269|PubMed:18507738}.
uniprot
proteins