PHETA1
entrez
144717
canonical
uniprot
Q8N4B1
canonical
ensembl
ENSG00000198324
resolver
ensp
ENSP00000354461
resolver
ensp
ENSP00000447353
resolver
ensp
ENSP00000507123
resolver
ensp
ENSP00000560650
resolver
ensp
ENSP00000560652
resolver
genesymbol
PHETA1
resolver
genesymbol_syn
FAM109A
resolver
hgnc
HGNC:26509
resolver
uniprot
J3KP50
resolver
uniprot
Q6PJL9
resolver
uniprot
Q96MH8
resolver
uniprot_entry
SESQ1_HUMAN
resolver
uniprot_sec
J3KP50
resolver
uniprot_sec
Q6PJL9
resolver
uniprot_sec
Q96MH8
resolver
amino_acid_sequence
MKLNERSLAFYATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGVIILEGCTVELVEAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRASFDYLRLVVRELEQQLAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPSLPSAPAPVPALPLPRRPSALPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFARLHECYGQEIRALRGQWLSSRVQP
uniprot
proteins
function
FUNCTION: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. {ECO:0000269|PubMed:21233288}.
uniprot
proteins
mass_dalton
27215
uniprot
proteins
mutagenesis
MUTAGEN 224; /note="F->A: Loss of OCRL-binding. Drastically reduces membrane targeting."; /evidence="ECO:0000269|PubMed:20133602, ECO:0000269|PubMed:21233288"; MUTAGEN 228; /note="H->A: Loss of OCRL-binding."; /evidence="ECO:0000269|PubMed:20133602, ECO:0000269|PubMed:21233288"; MUTAGEN 234..235; /note="EI->AA: Loss of OCRL-binding."; /evidence="ECO:0000269|PubMed:21233288
uniprot
proteins
protein_family
Sesquipedalian family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
20133602
uniprot
proteins
pubmed
21233288
uniprot
proteins
pubmed
21666675
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:21233288}. Recycling endosome {ECO:0000269|PubMed:21233288}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:21233288}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:21233288}. Note=Interaction with OCRL may be crucial for targeting to endosome and to the trans-Golgi network. Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes. {ECO:0000269|PubMed:20133602, ECO:0000269|PubMed:21233288}.
uniprot
proteins