Dnaja1
entrez
65028
canonical
uniprot
P63036
canonical
ensembl
ENSRNOG00000007029
resolver
ensembl
ENSRNOG00055016378
resolver
ensembl
ENSRNOG00060003657
resolver
ensembl
ENSRNOG00065004655
resolver
ensp
ENSRNOP00000010061
resolver
ensp
ENSRNOP00055022299
resolver
ensp
ENSRNOP00060004449
resolver
ensp
ENSRNOP00065004642
resolver
enst
ENSRNOT00000010061
resolver
enst
ENSRNOT00055027767
resolver
enst
ENSRNOT00060006030
resolver
enst
ENSRNOT00065006743
resolver
genesymbol
Dnaja1
resolver
genesymbol_syn
Hsj2
resolver
genesymbol_syn
Rdj1
resolver
uniprot
P54102
resolver
uniprot_entry
DNJA1_RAT
resolver
uniprot_sec
P54102
resolver
amino_acid_sequence
MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLADSKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS
uniprot
proteins
function
FUNCTION: Functions as a co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (By similarity). Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone (PubMed:10816573). {ECO:0000250, ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:9605323}.
uniprot
proteins
mass_dalton
44868
uniprot
proteins
pubmed
10816573
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9605323
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:10816573}. Microsome {ECO:0000269|PubMed:10816573}. Mitochondrion {ECO:0000269|PubMed:10816573}. Nucleus {ECO:0000269|PubMed:10816573}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Primarily cytoplasmic and associated with microsomes. A minor proportion is associated with nuclei and mitochondria.
uniprot
proteins