Nt5dc2
entrez
290558
canonical
uniprot
Q6Q0N3
canonical
ensembl
ENSRNOG00000018358
resolver
ensp
ENSRNOP00000024840
resolver
genesymbol
Nt5dc2
resolver
uniprot
Q5M7U9
resolver
uniprot_entry
NT5D2_RAT
resolver
uniprot_sec
Q5M7U9
resolver
amino_acid_sequence
MAGAGLRAAARRWLLCGGQGGPRAASSSPSCPGCGPPGPGAHCPSTPRSAPADGADLSAHLWARYQDMRRLVHDLLPPEVCSLLNPAAIYANNEISLSDVEVYGFDYDYTLAQYADALHPEIFSAARDILIEHYKYPEGIRKYDYDPSFAIRGLHYDIQKSLLMKIDAFHYVQLGTAYRGLQPVPDDEVVDLYGGTQHIPLYQMSGFYGKGPSIKQFMDIFSLPEMALLSCVVDYFLGHGLEFDQVHLYKDVTDAIRDVHVKGLMYQWIEQDMEKYILRGDETFAVLSRLVAHGKQLFLITNSPFSFVDKGMRHMVGPDWRQLFDVVIVQADKPNFFTDRRKPFRKLDEKGSLHWDRITRLEKGKIYRQGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRIINTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLATWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLNYSVDFTFYPRRTPLQHEAPLWMDQLCTGCMKTPFLGDMAHIR
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
function
FUNCTION: Promotes dephosphorylation of tyrosine 3-monooxygenase TH which decreases TH catalytic activity and leads to reduced synthesis of catecholamines including dopamine, noradrenaline and adrenaline (PubMed:31279527, PubMed:32778969, PubMed:38382359). The exact mechanism of activity is unknown but may act as a phosphatase or promote the activity of phosphatases or may inhibit phosphorylation by acting as a barrier to interfere with protein kinase access (PubMed:32778969, PubMed:38382359). {ECO:0000269|PubMed:31279527, ECO:0000269|PubMed:32778969, ECO:0000269|PubMed:38382359}.
uniprot
proteins
mass_dalton
63653
uniprot
proteins
protein_family
5'(3')-deoxyribonucleotidase family
uniprot
proteins
pubmed
15326124
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
31279527
uniprot
proteins
pubmed
32778969
uniprot
proteins
pubmed
38382359
uniprot
proteins
sequence_length
553
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32778969}.
uniprot
proteins