Dtx3
entrez
80904
canonical
uniprot
Q80V91
canonical
ensembl
ENSMUSG00000040415
resolver
ensp
ENSMUSP00000044627
resolver
ensp
ENSMUSP00000111937
resolver
ensp
ENSMUSP00000114776
resolver
enst
ENSMUST00000038217
resolver
enst
ENSMUST00000116229
resolver
enst
ENSMUST00000130855
resolver
genesymbol
Dtx3
resolver
uniprot
D3YV13
resolver
uniprot
E9Q3J1
resolver
uniprot
Q4FZD3
resolver
uniprot
Q9ER06
resolver
uniprot_entry
D3YV13_MOUSE
resolver
uniprot_entry
DTX3_MOUSE
resolver
uniprot_entry
E9Q3J1_MOUSE
resolver
uniprot_sec
Q4FZD3
resolver
uniprot_sec
Q9ER06
resolver
amino_acid_sequence
MSFVLSRMAACGGSCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVLQLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPELHRPGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREDAEEQETTCPICLGEIQNAKTLEKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Functions as an ubiquitin ligase protein, and regulates Notch signaling. By promoting the ubiquitination and subsequent degradation of target proteins, it can block activation of the Notch signaling pathway, potentially acting as a tumor suppressor in human cancers. {ECO:0000250|UniProtKB:Q8N9I9}.
uniprot
proteins
mass_dalton
37982
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
Deltex family
uniprot
proteins
pubmed
11226752
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
347
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8N9I9}. Nucleus {ECO:0000250|UniProtKB:Q8N9I9}.
uniprot
proteins