Nmur2
entrez
216749
canonical
uniprot
Q8BZ39
canonical
ensembl
ENSMUSG00000037393
resolver
ensp
ENSMUSP00000044718
resolver
enst
ENSMUST00000037682
resolver
genesymbol
Nmur2
resolver
uniprot
Q91Z76
resolver
uniprot_entry
NMUR2_MOUSE
resolver
uniprot_sec
Q91Z76
resolver
amino_acid_sequence
MGKLENASWIHDSLMKYLNSTEEYLAYLCGPKRSDLSLPVSVVYALIFVVGVIGNLLVCLVIARHQTLKTPTNYYLFSLAVSDLLVLLLGMPLEVYELWHNYPFLFGPVGCYFKTALFETVCFASILSVTTVSIERYVAIVHPFRAKLESTRRRALRILSLVWSFSVVFSLPNTSIHGIKFQQFPNGSSVPGSATCTVTKPIWVYNFIIQATSFLFYILPMTLISVLYYLMGLRLKRDESLEADKVTVNIHRPSRKSVTKMLFVLVLVFAICWTPFHVDRLFFSFVDEWTESLAAVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRAAFRNVVSPSCKWCHPQHRPQGPPAQKVIFLTECHLVELTEDAGPQFPCQSSIHNTQLTTVPCVEEVP
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for the neuropeptides neuromedin-U (NMU) and neuromedin-S (NMS) (PubMed:12217421). Functionally, is involved in regulation of feeding and energy balance (By similarity). Additionally may modulates blood pressure and smooth muscle contraction (By similarity). Mechanistically, upon ligand binding, couples to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits. GNAQ/Gaq or GNA11/Ga11 coupling leads to the activation of a phospholipase C (PLC), which hydrolyzes PIP2 (phosphatidylinositol 4,5-bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate), and subsequent intracellular calcium mobilization via IP3 receptors on the endoplasmic reticulum. GNAI1/Gai coupling inhibits forskolin-stimulated cAMP accumulation (By similarity). {ECO:0000250|UniProtKB:P12760, ECO:0000250|UniProtKB:Q9ESQ4, ECO:0000250|UniProtKB:Q9GZQ4, ECO:0000269|PubMed:12217421}.
uniprot
proteins
mass_dalton
44827
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12217421
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9GZQ4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9GZQ4}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..60; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9GZQ4"; TRANSMEM 75..98; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9GZQ4"; TRANSMEM 108..134; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9GZQ4"; TRANSMEM 156..176; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9GZQ4"; TRANSMEM 204..229; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9GZQ4"; TRANSMEM 260..282; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9GZQ4"; TRANSMEM 299..322; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9GZQ4
uniprot
proteins