CYP2B6
entrez
1555
canonical
uniprot
P20813
canonical
ensembl
ENSG00000197408
resolver
ensp
ENSP00000324648
resolver
genesymbol
CYP2B6
resolver
hgnc
HGNC:2615
resolver
uniprot
B4DWP3
resolver
uniprot
Q2V565
resolver
uniprot
Q9UK46
resolver
uniprot_entry
CP2B6_HUMAN
resolver
uniprot_sec
B4DWP3
resolver
uniprot_sec
Q2V565
resolver
uniprot_sec
Q9UK46
resolver
amino_acid_sequence
MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR
uniprot
proteins
ec_number
1.14.13.-
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed:12865317, PubMed:21289075). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PubMed:12865317, PubMed:21289075). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PubMed:11695850, PubMed:22909231). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). {ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:21289075, ECO:0000269|PubMed:22909231}.; FUNCTION: Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs. {ECO:0000269|PubMed:21289075}.
uniprot
proteins
mass_dalton
56278
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is accompanied by a decrease in enzyme activity. {ECO:0000250}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10768437
uniprot
proteins
pubmed
11243870
uniprot
proteins
pubmed
11470993
uniprot
proteins
pubmed
11695850
uniprot
proteins
pubmed
12642465
uniprot
proteins
pubmed
12721789
uniprot
proteins
pubmed
12865317
uniprot
proteins
pubmed
14551287
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15190123
uniprot
proteins
pubmed
15194512
uniprot
proteins
pubmed
15469410
uniprot
proteins
pubmed
15622315
uniprot
proteins
pubmed
20061448
uniprot
proteins
pubmed
20639527
uniprot
proteins
pubmed
20860463
uniprot
proteins
pubmed
21289075
uniprot
proteins
pubmed
21875942
uniprot
proteins
pubmed
22909231
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2573390
uniprot
proteins
pubmed
2813061
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
uniprot
proteins