Scn4a
entrez
25722
canonical
uniprot
P15390
canonical
ensembl
ENSRNOG00000012134
resolver
ensp
ENSRNOP00000016841
resolver
enst
ENSRNOT00000016841
resolver
genesymbol
Scn4a
resolver
uniprot
D3ZW75
resolver
uniprot
O70611
resolver
uniprot_entry
D3ZW75_RAT
resolver
uniprot_entry
SCN4A_RAT
resolver
uniprot_sec
O70611
resolver
activity_regulation
ACTIVITY REGULATION: Potently inhibited by tetrodotoxin and saxitoxin (PubMed:16303569, PubMed:23077250). Inhibited by the conotoxin GVIIJ (PubMed:24497506). {ECO:0000269|PubMed:16303569, ECO:0000269|PubMed:23077250, ECO:0000269|PubMed:24497506}.
uniprot
proteins
amino_acid_sequence
MASSSLPNLVPPGPHCLRPFTPESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLPLIYGDPPPEVIGIPLEDLDPYYSDKKTFIVLNKGKAIFRFSATPALYLLSPFSIVRRVAIKVLIHALFSMFIMITILTNCVFMTMSNPPSWSKHVEYTFTGIYTFESLIKMLARGFCIDDFTFLRDPWNWLDFSVITMAYVTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPMNDTNTTWYGNDTWYSNDTWYGNDTWYINDTWNSQESWAGNSTFDWEAYINDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKAGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDQEKEEEFQQMLEKYKKHQEELEKAKAAQALESGEEADGDPTHNKDCNGSLDASGEKGPPRPSCSADSAISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWVKFKHIIYLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLSVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSFIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIASDCNLPRWHMNDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKWGIGFAKTFLLGLLRGKILSPKEIILSLGEPGGAGENAEESTPEDEKKEPPPEDKELKDNHILNHVGLTDGPRSSIELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDAFSEPEDIKKPLQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGEQPEECFTEACVKRCPCLYVDISQGRGKMWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFILEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCVNTTTSERFDISVVNNKSESESLMYTGQVRWMNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPHYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDFVTKQVFDISIMILICLNMVTMMVETDDQSQLKVDILYNINMVFIIIFTGECVLKMFALRHYYFTIGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPTLENPGTNVRGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLSEDDFEMFYETWEKFDPDATQFIDYSRLSDFVDTLQEPLKIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKQEEVCAIKIQRAYRRHLLQRSVKQASYMYRHSQDGNDDGAPEKEGLLANTMNKMYGHEKEGDGVQSQGEEEKASTEDAGPTVEPEPTSSSDTALTPSPPPLPPSSSPPQGQTVRPGVKESLV
uniprot
proteins
function
FUNCTION: Pore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:16303569, PubMed:2559760, PubMed:28012039). Highly expressed in skeletal muscles, Nav1.4 generates the action potential crucial for muscle contraction (By similarity). {ECO:0000250|UniProtKB:P35499, ECO:0000269|PubMed:16303569, ECO:0000269|PubMed:2559760, ECO:0000269|PubMed:28012039}.
uniprot
proteins
mass_dalton
208867
uniprot
proteins
mutagenesis
MUTAGEN 401; /note="Y->C,N: Strongly reduced sensitivity to tetrodotoxin."; /evidence="ECO:0000269|PubMed:16303569"; MUTAGEN 1240..1241; /note="MD->TI: Strongly reduced sensitivity to saxitoxin."; /evidence="ECO:0000269|PubMed:23077250"; MUTAGEN 1303..1305; /note="Missing: Loss of rapid channel inactivation."; /evidence="ECO:0000269|PubMed:28012039"; MUTAGEN 1379; /note="Y->S: Become sensitive to the spider beta/delta-theraphotoxin-Pre1a, which inhibits inactivation of the channel."; /evidence="ECO:0000269|PubMed:28428547"; MUTAGEN 1380; /note="N->R: No change in sensitivity to the spider beta/delta-theraphotoxin-Pre1a."; /evidence="ECO:0000269|PubMed:28428547
uniprot
proteins
protein_family
Nav1.4/SCN4A subfamily
uniprot
proteins
protein_family
Sodium channel (TC 1.A.1.10) family
uniprot
proteins
pubmed
16303569
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23077250
uniprot
proteins
pubmed
24497506
uniprot
proteins
pubmed
2559760
uniprot
proteins
pubmed
28012039
uniprot
proteins
pubmed
28428547
uniprot
proteins
pubmed
30389410
uniprot
proteins
pubmed
9613589
uniprot
proteins
sequence_length
1840
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16303569, ECO:0000269|PubMed:2559760, ECO:0000269|PubMed:28012039}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P35499}.
uniprot
proteins
transmembrane_region
TRANSMEM 132..150; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 158..178; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 193..210; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 217..233; /note="Helical; Name=S4 of repeat I"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 253..272; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 418..438; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 573..591; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 603..622; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 637..656; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 659..676; /note="Helical; Name=S4 of repeat II"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 693..711; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 773..791; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 1026..1043; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 1057..1075; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 1090..1108; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 1117..1135; /note="Helical; Name=S4 of repeat III"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 1153..1172; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 1263..1284; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 1348..1365; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 1377..1395; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 1408..1425; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 1439..1455; /note="Helical; Name=S4 of repeat IV"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 1475..1492; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000250|UniProtKB:P35499"; TRANSMEM 1568..1590; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000250|UniProtKB:P35499
uniprot
proteins