Ap2s1
entrez
232910
canonical
uniprot
P62743
canonical
ensembl
ENSMUSG00000008036
resolver
ensp
ENSMUSP00000083281
resolver
enst
ENSMUST00000086112
resolver
genesymbol
Ap2s1
resolver
genesymbol_syn
Ap17
resolver
genesymbol_syn
Claps2
resolver
uniprot
P70626
resolver
uniprot
P97626
resolver
uniprot
Q00380
resolver
uniprot
Q3UJ76
resolver
uniprot_entry
AP2S1_MOUSE
resolver
uniprot_entry
Q3UJ76_MOUSE
resolver
uniprot_sec
P70626
resolver
uniprot_sec
P97626
resolver
uniprot_sec
Q00380
resolver
amino_acid_sequence
MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYRRYAGLYFCICVDVNDNNLAYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVLKQLLMLQSLE
uniprot
proteins
function
FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. May also play a role in extracellular calcium homeostasis (By similarity). {ECO:0000250, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838}.
uniprot
proteins
mass_dalton
17018
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="R->S: Reduces interaction with CD4 endocytosis signal motif; when associated with AP2A2 E-21."; /evidence="ECO:0000269|PubMed:19140243"; MUTAGEN 62; /note="Y->S: Abolishes interaction with CD4 endocytosis signal motif."; /evidence="ECO:0000269|PubMed:19140243"; MUTAGEN 63; /note="A->W: Abolishes interaction with CD4 endocytosis signal motif."; /evidence="ECO:0000269|PubMed:19140243"; MUTAGEN 65; /note="L->S: Slightly reduces interaction with CD4 endocytosis signal motif."; /evidence="ECO:0000269|PubMed:19140243"; MUTAGEN 88; /note="V->D: Abolishes interaction with CD4 endocytosis signal motif."; /evidence="ECO:0000269|PubMed:19140243"; MUTAGEN 92; /note="N->W: Abolishes interaction with CD4 endocytosis signal motif."; /evidence="ECO:0000269|PubMed:19140243"; MUTAGEN 98; /note="V->F: Reduces interaction with CD4 endocytosis signal motif."; /evidence="ECO:0000269|PubMed:19140243"; MUTAGEN 98; /note="V->S: Abolishes interaction with CD4 endocytosis signal motif."; /evidence="ECO:0000269|PubMed:19140243"; MUTAGEN 100; /note="E->Y: Abolishes interaction with CD4 endocytosis signal motif."; /evidence="ECO:0000269|PubMed:19140243"; MUTAGEN 103; /note="L->S: Abolishes interaction with CD4 endocytosis signal motif."; /evidence="ECO:0000269|PubMed:19140243
uniprot
proteins
protein_family
Adaptor complexes small subunit family
uniprot
proteins
pubmed
12086608
uniprot
proteins
pubmed
14745134
uniprot
proteins
pubmed
15473838
uniprot
proteins
pubmed
19140243
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
142
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P63010}. Membrane, coated pit {ECO:0000250|UniProtKB:P53680}; Peripheral membrane protein {ECO:0000250|UniProtKB:P53680}; Cytoplasmic side {ECO:0000250|UniProtKB:P53680}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250|UniProtKB:P63010}.
uniprot
proteins