LAMP5
entrez
24141
canonical
uniprot
Q9UJQ1
canonical
ensembl
ENSG00000125869
resolver
ensp
ENSP00000246070
resolver
ensp
ENSP00000406360
resolver
genesymbol
LAMP5
resolver
genesymbol_syn
C20orf103
resolver
hgnc
HGNC:16097
resolver
uniprot
B4DHZ7
resolver
uniprot
B7Z9Z9
resolver
uniprot_entry
LAMP5_HUMAN
resolver
uniprot_sec
B4DHZ7
resolver
uniprot_sec
B7Z9Z9
resolver
amino_acid_sequence
MDLQGRGVPSIDRLRVLLMLFHTMAQIMAEQEVENLSGLSTNPEKDIFVVRENGTTCLMAEFAAKFIVPYDVWASNYVDLITEQADIALTRGAEVKGRCGHSQSELQVFWVDRAYALKMLFVKESHNMSKGPEATWRLSKVQFVYDSSEKTHFKDAVSAGKHTANSHHLSALVTPAGKSYECQAQQTISLASSDPQKTVTMILSAVHIQPFDIISDFVFSEEHKCPVDEREQLEETLPLILGLILGLVIMVTLAIYHVHHKMTANQVQIPRDRSQYKHMG
uniprot
proteins
function
FUNCTION: Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain. {ECO:0000250|UniProtKB:Q9D387}.
uniprot
proteins
mass_dalton
31472
uniprot
proteins
mutagenesis
MUTAGEN 276; /note="Y->A: Cell surface localization."; /evidence="ECO:0000269|PubMed:21642595
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q9D387}.
uniprot
proteins
protein_family
LAMP family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21642595
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
280
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21642595}; Single-pass type I membrane protein {ECO:0000269|PubMed:21642595}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9D387}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:21642595}; Single-pass type I membrane protein {ECO:0000269|PubMed:21642595}. Endosome membrane {ECO:0000269|PubMed:21642595}; Single-pass type I membrane protein {ECO:0000269|PubMed:21642595}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9D387}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9D387}. Cell projection, growth cone membrane {ECO:0000250|UniProtKB:Q9D387}; Single-pass type I membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000250|UniProtKB:Q9D387}; Single-pass type I membrane protein {ECO:0000305}. Recycling endosome {ECO:0000250|UniProtKB:Q9D387}. Note=Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (By similarity). Colocalizes with UNC93B1 in large endosomal intracellular vesicles (PubMed:21642595). Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides (PubMed:21642595). Associates with cortical membranes (PubMed:21642595). Localizes mostly in cytoplasmic vesicles of neuronal cell body (By similarity). Localizes to synaptic vesicles in a subset of GABAergic neurons (By similarity). {ECO:0000250|UniProtKB:Q9D387, ECO:0000269|PubMed:21642595}.
uniprot
proteins
transmembrane_region
TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins