KLF10
entrez
7071
canonical
uniprot
Q13118
canonical
ensembl
ENSG00000155090
resolver
ensp
ENSP00000285407
resolver
ensp
ENSP00000379222
resolver
genesymbol
KLF10
resolver
genesymbol_syn
TIEG
resolver
genesymbol_syn
TIEG1
resolver
hgnc
HGNC:11810
resolver
uniprot
A8MVH0
resolver
uniprot
B2R794
resolver
uniprot
L0R4P6
resolver
uniprot
L0R679
resolver
uniprot
O75411
resolver
uniprot
Q503B2
resolver
uniprot_entry
KLF10_HUMAN
resolver
uniprot_sec
A8MVH0
resolver
uniprot_sec
B2R794
resolver
uniprot_sec
L0R4P6
resolver
uniprot_sec
L0R679
resolver
uniprot_sec
O75411
resolver
uniprot_sec
Q503B2
resolver
amino_acid_sequence
MLNFGASLQQTAEERMEMISERPKESMYSWNKTAEKSDFEAVEALMSMSCSWKSDFKKYVENRPVTPVSDLSEEENLLPGTPDFHTIPAFCLTPPYSPSDFEPSQVSNLMAPAPSTVHFKSLSDTAKPHIAAPFKEEEKSPVSAPKLPKAQATSVIRHTADAQLCNHQTCPMKAASILNYQNNSFRRRTHLNVEAARKNIPCAAVSPNRSKCERNTVADVDEKASAALYDFSVPSSETVICRSQPAPVSPQQKSVLVSPPAVSAGGVPPMPVICQMVPLPANNPVVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQSSKPPVVSPNGTRLSPIAPAPGFSPSAAKVTPQIDSSRIRSHICSHPGCGKTYFKSSHLKAHTRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDRRFMRSDHLTKHARRHLSAKKLPNWQMEVSKLNDIALPPTPAPTQ
uniprot
proteins
function
FUNCTION: Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. {ECO:0000250|UniProtKB:O89091, ECO:0000269|PubMed:8584037}.
uniprot
proteins
mass_dalton
52555
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. {ECO:0000269|PubMed:12072443}.
uniprot
proteins
protein_family
Sp1 C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
12072443
uniprot
proteins
pubmed
12804117
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23134681
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
8532536
uniprot
proteins
pubmed
8584037
uniprot
proteins
pubmed
9721211
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O89091}.
uniprot
proteins