Myl12b
entrez
50685
canonical
uniprot
P18666
canonical
ensembl
ENSRNOG00000091388
resolver
ensp
ENSRNOP00000045992
resolver
enst
ENSRNOT00000048125
resolver
genesymbol
Myl12b
resolver
genesymbol_syn
Mrlc2
resolver
genesymbol_syn
Mrlcb
resolver
genesymbol_syn
Mylc2b
resolver
uniprot
A0A0G2JSW0
resolver
uniprot
Q6P9V4
resolver
uniprot_entry
A0A0G2JSW0_RAT
resolver
uniprot_entry
ML12B_RAT
resolver
uniprot_sec
Q6P9V4
resolver
amino_acid_sequence
MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDAYLDAMMNEAPGRINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD
uniprot
proteins
function
FUNCTION: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. {ECO:0000269|PubMed:18835913}.
uniprot
proteins
mass_dalton
19838
uniprot
proteins
post_translational_modification
PTM: Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment. {ECO:0000250|UniProtKB:O14950}.
uniprot
proteins
pubmed
11384979
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18835913
uniprot
proteins
pubmed
2391362
uniprot
proteins
sequence_length
172
uniprot
proteins