SIGLEC10
entrez
89790
canonical
uniprot
Q96LC7
canonical
ensembl
ENSG00000142512
resolver
ensp
ENSP00000342389
resolver
ensp
ENSP00000345243
resolver
ensp
ENSP00000389132
resolver
ensp
ENSP00000395475
resolver
ensp
ENSP00000408387
resolver
ensp
ENSP00000414324
resolver
ensp
ENSP00000431444
resolver
ensp
ENSP00000631866
resolver
ensp
ENSP00000631867
resolver
enst
ENST00000525998
resolver
genesymbol
SIGLEC10
resolver
genesymbol_syn
SLG2
resolver
hgnc
HGNC:15620
resolver
uniprot
A8K1I5
resolver
uniprot
A8K3C7
resolver
uniprot
B7ZL06
resolver
uniprot
C9JJ33
resolver
uniprot
C9JM10
resolver
uniprot
E9PL79
resolver
uniprot
F8W917
resolver
uniprot
Q3MIR5
resolver
uniprot
Q6UXI8
resolver
uniprot
Q96G54
resolver
uniprot
Q96LC8
resolver
uniprot_entry
B7ZL06_HUMAN
resolver
uniprot_entry
E9PL79_HUMAN
resolver
uniprot_entry
SIG10_HUMAN
resolver
uniprot_sec
A8K1I5
resolver
uniprot_sec
A8K3C7
resolver
uniprot_sec
C9JJ33
resolver
uniprot_sec
C9JM10
resolver
uniprot_sec
F8W917
resolver
uniprot_sec
Q3MIR5
resolver
uniprot_sec
Q6UXI8
resolver
uniprot_sec
Q96G54
resolver
uniprot_sec
Q96LC8
resolver
amino_acid_sequence
MLLPLLLSSLLGGSQAMDGRFWIRVQESVMVPEGLCISVPCSFSYPRQDWTGSTPAYGYWFKAVTETTKGAPVATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVRYNFMNDGFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTGAALSSQGTKPTTSHFSVLSFTPRPQDHNTDLTCHVDFSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLCLVCVTHSSPPARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCHARHPLGSQHVSLSLSVHYSPKLLGPSCSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQDSFEVTPSSAGPWANSSLSLHGGLSSGLRLRCEAWNVHGAQSGSILQLPDKKGLISTAFSNGAFLGIGITALLFLCLALIIMKILPKRRTQTETPRPRFSRHSTILDYINVVPTAGPLAQKRNQKATPNSPRTPLPPGAPSPESKKNQKKQYQLPSFPEPKSSTQAPESQESQEELHYATLNFPGVRPRPEARMPKGTQADYAEVKFQ
uniprot
proteins
function
FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity). {ECO:0000250|UniProtKB:Q80ZE3, ECO:0000269|PubMed:11284738, ECO:0000269|PubMed:25450598, ECO:0000305|PubMed:12163025}.
uniprot
proteins
mass_dalton
76592
uniprot
proteins
mutagenesis
MUTAGEN 119; /note="R->A: Disrupts interaction with CD24."; /evidence="ECO:0000269|PubMed:19264983"; MUTAGEN 667; /note="Y->F: Abolishes binding to PTPN6."; /evidence="ECO:0000269|PubMed:12163025
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Tyr-667 is involved in binding to PTPN6. {ECO:0000269|PubMed:12163025}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
SIGLEC (sialic acid binding Ig-like lectin) family
uniprot
proteins
pubmed
11284738
uniprot
proteins
pubmed
11358961
uniprot
proteins
pubmed
11409878
uniprot
proteins
pubmed
12163025
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19264983
uniprot
proteins
pubmed
25450598
uniprot
proteins
sequence_length
697
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 551..571; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins