RAB14
entrez
51552
canonical
uniprot
P61106
canonical
ensembl
ENSG00000119396
resolver
ensp
ENSP00000362946
resolver
ensp
ENSP00000515613
resolver
ensp
ENSP00000515614
resolver
ensp
ENSP00000587686
resolver
ensp
ENSP00000642733
resolver
enst
ENST00000373840
resolver
enst
ENST00000703999
resolver
enst
ENST00000704000
resolver
enst
ENST00000917627
resolver
enst
ENST00000972674
resolver
genesymbol
RAB14
resolver
hgnc
HGNC:16524
resolver
uniprot
B3KR31
resolver
uniprot
P35287
resolver
uniprot
Q5JVD4
resolver
uniprot
Q6Q7K5
resolver
uniprot
Q969L0
resolver
uniprot
Q9UI11
resolver
uniprot_entry
RAB14_HUMAN
resolver
uniprot_sec
B3KR31
resolver
uniprot_sec
P35287
resolver
uniprot_sec
Q5JVD4
resolver
uniprot_sec
Q6Q7K5
resolver
uniprot_sec
Q969L0
resolver
uniprot_sec
Q9UI11
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including DENND6A and DENND6B which promote the exchange of bound GDP for free GTP (PubMed:22595670). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation (Probable). {ECO:0000269|PubMed:22595670, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:22595670). RAB14 is involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development (By similarity). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (PubMed:22595670). Mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB4B (PubMed:20534812). Interaction with RAB11FIP1 may function in the process of neurite formation (PubMed:26032412). {ECO:0000250|UniProtKB:P61107, ECO:0000250|UniProtKB:Q91V41, ECO:0000269|PubMed:20534812, ECO:0000269|PubMed:22595670, ECO:0000269|PubMed:26032412}.
uniprot
proteins
mass_dalton
23897
uniprot
proteins
mutagenesis
MUTAGEN 25; /note="S->N: Dominant-negative mutant (GDP-bound form). Loss of interaction with RUFY1."; /evidence="ECO:0000269|PubMed:20534812"; MUTAGEN 70; /note="Q->L: Constitutively active mutant (GTP-bound form). Interacts with RUFY1."; /evidence="ECO:0000269|PubMed:20534812
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16034420
uniprot
proteins
pubmed
16962593
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20534812
uniprot
proteins
pubmed
21255211
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22595670
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26032412
uniprot
proteins
sequence_length
215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome {ECO:0000269|PubMed:22595670}. Early endosome membrane {ECO:0000269|PubMed:16962593, ECO:0000269|PubMed:20534812}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:16962593}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:16962593}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle {ECO:0000269|PubMed:26032412}. Note=Recruited to recycling endosomes by DENND6A (PubMed:22595670). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). Colocalizes with RAB11FIP1 on punctate vesicles (PubMed:26032412). {ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:22595670, ECO:0000269|PubMed:26032412}.
uniprot
proteins