AGPAT2
entrez
10555
canonical
uniprot
O15120
canonical
ensembl
ENSG00000169692
resolver
ensp
ENSP00000360759
resolver
ensp
ENSP00000360761
resolver
genesymbol
AGPAT2
resolver
hgnc
HGNC:325
resolver
uniprot
A0A024R8F9
resolver
uniprot
O00516
resolver
uniprot
O15106
resolver
uniprot
Q5VUD3
resolver
uniprot
Q5VUD4
resolver
uniprot
Q9BSV7
resolver
uniprot
Q9BWR7
resolver
uniprot_entry
A0A024R8F9_HUMAN
resolver
uniprot_entry
PLCB_HUMAN
resolver
uniprot_sec
O00516
resolver
uniprot_sec
O15106
resolver
uniprot_sec
Q5VUD3
resolver
uniprot_sec
Q5VUD4
resolver
uniprot_sec
Q9BSV7
resolver
uniprot_sec
Q9BWR7
resolver
amino_acid_sequence
MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ
uniprot
proteins
disease_involvement
DISEASE: Lipodystrophy, congenital generalized, 1 (CGL1) [MIM:608594]: A form of congenital generalized lipodystrophy, a metabolic disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. Inheritance is autosomal recessive. {ECO:0000269|PubMed:11967537, ECO:0000269|PubMed:15629135}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.3.1.51
uniprot
proteins
function
FUNCTION: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. {ECO:0000269|PubMed:15629135, ECO:0000269|PubMed:19075029, ECO:0000269|PubMed:21873652, ECO:0000269|PubMed:9242711}.
uniprot
proteins
mass_dalton
30914
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
uniprot
proteins
protein_family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
uniprot
proteins
pubmed
11967537
uniprot
proteins
pubmed
15028826
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15629135
uniprot
proteins
pubmed
19075029
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21873652
uniprot
proteins
pubmed
9212163
uniprot
proteins
pubmed
9242711
uniprot
proteins
pubmed
9291118
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21873652}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 122..142; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins