Hand1
entrez
59112
canonical
uniprot
P97832
canonical
ensembl
ENSRNOG00000002582
resolver
ensembl
ENSRNOG00055028788
resolver
ensembl
ENSRNOG00060023832
resolver
ensembl
ENSRNOG00065007426
resolver
ensp
ENSRNOP00000003486
resolver
ensp
ENSRNOP00055041052
resolver
ensp
ENSRNOP00060034178
resolver
ensp
ENSRNOP00065008439
resolver
enst
ENSRNOT00000003486
resolver
enst
ENSRNOT00055049854
resolver
enst
ENSRNOT00060041261
resolver
enst
ENSRNOT00065011582
resolver
genesymbol
Hand1
resolver
genesymbol_syn
Ehand
resolver
uniprot
Q4V8L8
resolver
uniprot_entry
HAND1_RAT
resolver
uniprot_sec
Q4V8L8
resolver
amino_acid_sequence
MNLVGSYAHHHHHHHSHPPHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGGPPPTTAVAAAAYGPDARPSQSPGRLEALGGRLPRRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQAGDPEAFKAELKKTDGGRESKRKRESPQQHEGLPPALGPSEKRIKGRTGWPQQVWALELNQ
uniprot
proteins
function
FUNCTION: Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity). {ECO:0000250|UniProtKB:O96004, ECO:0000250|UniProtKB:Q64279}.
uniprot
proteins
mass_dalton
23810
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PLK4 disrupts the interaction with MDFIC and leads to translocation into the nucleoplasm, allowing dimerization and transcription factor activity. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity). {ECO:0000250}.
uniprot
proteins