Poli
entrez
26447
canonical
uniprot
Q6R3M4
canonical
ensembl
ENSMUSG00000038425
resolver
ensp
ENSMUSP00000039869
resolver
ensp
ENSMUSP00000112563
resolver
ensp
ENSMUSP00000123964
resolver
ensp
ENSMUSP00000124877
resolver
ensp
ENSMUSP00000279159
resolver
ensp
ENSMUSP00000279167
resolver
enst
ENSMUST00000043286
resolver
enst
ENSMUST00000121674
resolver
enst
ENSMUST00000159389
resolver
enst
ENSMUST00000161542
resolver
genesymbol
Poli
resolver
genesymbol_syn
Rad30b
resolver
uniprot
A0A0R4J1Z5
resolver
uniprot
E9Q3H9
resolver
uniprot
E9QJU6
resolver
uniprot
G8DM23
resolver
uniprot
Q641P1
resolver
uniprot
Q6R3M3
resolver
uniprot
Q9R1A6
resolver
uniprot_entry
A0A0R4J1Z5_MOUSE
resolver
uniprot_entry
E9Q3H9_MOUSE
resolver
uniprot_entry
E9QJU6_MOUSE
resolver
uniprot_entry
G8DM23_MOUSE
resolver
uniprot_entry
POLI_MOUSE
resolver
uniprot_sec
Q641P1
resolver
uniprot_sec
Q6R3M3
resolver
uniprot_sec
Q9R1A6
resolver
amino_acid_sequence
MEPLHAGAAGSSRAVCSQGPPTQISSSRVIVHVDLDCFYAQVEMISNPELKDRPLGVQQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGEDLSRYREMSYKVTELLEEFSPAVERLGFDENFVDLTEMVEKRLQQLPSEEVPSVTVFGHVYNNQSVNLHNIMHRRLVVGSQIAAEMREAMYNQLGLTGCAGVAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIAIAQRIQQLSFGEDKSPVTPSGPPQSFSEEDTFKKCSSEVEAKAKIEELLSSLLTRVCQDGRKPHTVRLVIRRYSDKHCNRESRQCPIPSHVIQKLGTGNHDSMPPLIDILMKLFRNMVNVKMPFHLTLMSVCFCNLKALSSAKKGPMDCYLTSLSTPAYTDKRAFKVKDTHTEDSHKEKEANWDCLPSRRIESTGTGESPLDATCFPKEKDTSDLPLQALPEGVDQEVFKQLPADIQEEILYGKSRENLKGKGSLSCPLHASRGVLSFFSTKQMQASRLSPRDTALPSKRVSAASPCEPGTSGLSPGSTSHPSCGKDCSYYIDSQLKDEQTSQGPTESQGCQFSSTNPAVSGFHSFPNLQTEQLFSTHRTVDSHKQTATASHQGLESHQGLESRELDSAEEKLPFPPDIDPQVFYELPEEVQKELMAEWERAGAARPSAHR
uniprot
proteins
ec_number
2.7.7.7
uniprot
proteins
function
FUNCTION: Error-prone DNA polymerase specifically involved in DNA repair (PubMed:15026325, PubMed:16357261). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:15026325, PubMed:16357261). Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template (By similarity). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (By similarity). May play a role in hypermutation of immunoglobulin genes (By similarity). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (By similarity). {ECO:0000250|UniProtKB:Q9UNA4, ECO:0000269|PubMed:15026325, ECO:0000269|PubMed:16357261}.
uniprot
proteins
mass_dalton
79653
uniprot
proteins
mutagenesis
MUTAGEN 496..524; /note="Missing: Abolishes ubiquitin binding and localization to nuclear foci after UV-induced DNA damage."; /evidence="ECO:0000269|PubMed:16357261"; MUTAGEN 508; /note="L->A: Impairs ubiquitin binding and post-translation modification via ubiquitination; when associated with A-509. Abolishes ubiquitin binding and localization to nuclear foci after UV-induced DNA damage but does not affect catalytic activity; when associated with A-508, A-693 and A-694."; /evidence="ECO:0000269|PubMed:16357261"; MUTAGEN 509; /note="P->A: Impairs ubiquitin binding and post-translation modification via ubiquitination; when associated with A-508. Abolishes ubiquitin binding and localization to nuclear foci after UV-induced DNA damage but does not affect catalytic activity; when associated with A-509, A-693 and A-694."; /evidence="ECO:0000269|PubMed:16357261"; MUTAGEN 681..709; /note="Missing: Abolishes ubiquitin binding and localization to nuclear foci after UV-induced DNA damage."; /evidence="ECO:0000269|PubMed:16357261"; MUTAGEN 693; /note="L->A: Impairs ubiquitin binding and post-translation modification via ubiquitination; when associated with A-694. Abolishes ubiquitin binding and localization to nuclear foci after UV-induced DNA damage but does not affect catalytic activity; when associated with A-508, A-509 and A-694."; /evidence="ECO:0000269|PubMed:16357261"; MUTAGEN 694; /note="P->A: Impairs ubiquitin binding and post-translation modification via ubiquitination; when associated with A-693. Abolishes ubiquitin binding and localization to nuclear foci after UV-induced DNA damage but does not affect catalytic activity; when associated with A-508, A-509 and A-693."; /evidence="ECO:0000269|PubMed:16357261
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated (PubMed:16357261). Protein monoubiquitination prevents POLI binding to ubiquitin via the ubiquitin-binding motif 1 and ubiquitin-binding motif 2 (PubMed:16357261). {ECO:0000269|PubMed:16357261}.
uniprot
proteins
protein_family
DNA polymerase type-Y family
uniprot
proteins
pubmed
10458907
uniprot
proteins
pubmed
14657033
uniprot
proteins
pubmed
15026325
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16357261
uniprot
proteins
sequence_length
717
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Binding to ubiquitin mediates localization to replication forks after UV-induced DNA damage. {ECO:0000269|PubMed:16357261}.
uniprot
proteins