MIMS1
entrez
125228
canonical
uniprot
Q96ND0
canonical
ensembl
ENSG00000177150
resolver
ensp
ENSP00000323635
resolver
ensp
ENSP00000386115
resolver
ensp
ENSP00000498370
resolver
ensp
ENSP00000633509
resolver
ensp
ENSP00000633510
resolver
ensp
ENSP00000633511
resolver
enst
ENST00000322247
resolver
enst
ENST00000402563
resolver
enst
ENST00000651643
resolver
enst
ENST00000963450
resolver
enst
ENST00000963451
resolver
enst
ENST00000963452
resolver
genesymbol
MIMS1
resolver
genesymbol_syn
C18orf19
resolver
genesymbol_syn
FAM210A
resolver
hgnc
HGNC:28346
resolver
uniprot
D3DUJ4
resolver
uniprot_entry
MIMS1_HUMAN
resolver
uniprot_sec
D3DUJ4
resolver
amino_acid_sequence
MQWNVPRTVSRLARRTCLEPHNAGLFGHCQNVKGPLLLYNAESKVVLVQGPQKQWLHLSAAQCVAKERRPLDAHPPQPGVLRHKQGKQHVSFRRVFSSSATAQGTPEKKEEPDPLQDKSISLYQRFKKTFRQYGKVLIPVHLITSGVWFGTFYYAALKGVNVVPFLELIGLPDSVVSILKNSQSGNALTAYALFKIATPARYTVTLGGTSVTVKYLRSHGYMSTPPPVKEYLQDRMEETKELITEKMEETKDRLTEKLQETKEKVSFKKKVE
uniprot
proteins
function
FUNCTION: Mitochondrial inner membrane protein essential for mitochondrial homeostasis, structural integrity, and cellular metabolism. Regulates mitochondrial translation by modulating protein synthesis of mitochondrial DNA-encoded genes. Plays a critical role in skeletal muscle mass and strength by regulating mitochondrial density, function, and protein synthesis. In brown adipose tissue, regulates mitochondrial cristae remodeling in response to cold stress by interacting with mitochondrial protease YME1L1 and enhancing its proteolytic activity, promoting OMA1 degradation and regulating OPA1 processing. Required for cardiac mitochondrial homeostasis and normal cardiomyocyte contractile function. In skeletal muscle, positively regulates myoblast differentiation by enhancing expression of myogenic factors. {ECO:0000250|UniProtKB:Q8BGY7}.
uniprot
proteins
mass_dalton
30777
uniprot
proteins
protein_family
MIMS family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22453275
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
272
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8BGY7}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8BGY7}.
uniprot
proteins
transmembrane_region
TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins