ESYT2
entrez
57488
canonical
uniprot
A0FGR8
canonical
ensembl
ENSG00000117868
resolver
ensp
ENSP00000251527
resolver
ensp
ENSP00000275418
resolver
ensp
ENSP00000550592
resolver
ensp
ENSP00000785913
resolver
enst
ENST00000251527
resolver
enst
ENST00000275418
resolver
genesymbol
ESYT2
resolver
genesymbol_syn
FAM62B
resolver
genesymbol_syn
KIAA1228
resolver
hgnc
HGNC:22211
resolver
uniprot
A0A499FIX8
resolver
uniprot
A4D229
resolver
uniprot
H7BXI1
resolver
uniprot
Q69YJ2
resolver
uniprot
Q6UKI4
resolver
uniprot
Q6ZTU0
resolver
uniprot
Q6ZVU1
resolver
uniprot
Q9BQS0
resolver
uniprot
Q9NW47
resolver
uniprot
Q9ULJ2
resolver
uniprot_entry
A0A499FIX8_HUMAN
resolver
uniprot_entry
ESYT2_HUMAN
resolver
uniprot_entry
H7BXI1_HUMAN
resolver
uniprot_sec
A4D229
resolver
uniprot_sec
Q69YJ2
resolver
uniprot_sec
Q6UKI4
resolver
uniprot_sec
Q6ZTU0
resolver
uniprot_sec
Q6ZVU1
resolver
uniprot_sec
Q9BQS0
resolver
uniprot_sec
Q9NW47
resolver
uniprot_sec
Q9ULJ2
resolver
amino_acid_sequence
MTANRDAALSSHRHPGCAQRPRTPTFASSSQRRSAFGFDDGNFPGLGERSHAPGSRLGARRRAKTARGLRGHRQRGAGAGLSRPGSARAPSPPRPGGPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT
uniprot
proteins
function
FUNCTION: Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877, ECO:0000269|PubMed:27044890}.
uniprot
proteins
mass_dalton
102357
uniprot
proteins
mutagenesis
MUTAGEN 401; /note="D->A: Abolishes calcium binding; when associated with A-413."; /evidence="ECO:0000269|PubMed:24373768"; MUTAGEN 413; /note="D->A: Abolishes calcium binding; when associated with A-401."; /evidence="ECO:0000269|PubMed:24373768"; MUTAGEN 413; /note="D->N: Strongly reduces calcium binding."; /evidence="ECO:0000269|PubMed:24373768"; MUTAGEN 466; /note="D->A: Impairs binding of the third calcium ion, but has no effect on the binding of the other two calcium ions."; /evidence="ECO:0000269|PubMed:24373768"; MUTAGEN 833..840; /note="KRRSGRRK->AAASGAAA: Abolishes location at the cell membrane."; /evidence="ECO:0000269|PubMed:23791178
uniprot
proteins
protein_family
Extended synaptotagmin family
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
11543631
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17360437
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20833364
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23791178
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24373768
uniprot
proteins
pubmed
24847877
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27044890
uniprot
proteins
pubmed
29469807
uniprot
proteins
pubmed
30220461
uniprot
proteins
sequence_length
921
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:29469807}; Peripheral membrane protein {ECO:0000269|PubMed:17360437}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:29469807}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:23791178, PubMed:27044890, PubMed:29469807, PubMed:30220461). Recruited to the cell membrane via the third C2 domain (PubMed:17360437). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:29469807, ECO:0000269|PubMed:30220461}.
uniprot
proteins
transmembrane_region
TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins