Scg3
entrez
116635
canonical
uniprot
P47868
canonical
ensembl
ENSRNOG00000010784
resolver
ensp
ENSRNOP00000014491
resolver
enst
ENSRNOT00000014491
resolver
genesymbol
Scg3
resolver
uniprot
F1M7L6
resolver
uniprot_entry
F1M7L6_RAT
resolver
uniprot_entry
SCG3_RAT
resolver
amino_acid_sequence
MGFLWTGSWILVLVLNSGPIQAFPKPEGSQDKSLHNRELSAERPLNEQIAEAEADKIKKTYPSESKPSESNFSSVDNLNLLKAITEKETVEKAKQSIRSSPFDNRLNVDDADSTKNRKLTDEYDSTKSGLDRKVQDDPDGLHQLDGTPLTAEDIVHKIATRIYEENDRGVFDKIVSKLLNLGLITESQAHTLEDEVAEALQKLISKEANNYEEAPEKPTSRTENQDGKIPEKVTPVAATQDGFTNRENDDTVSNTLTLSNGLERRTNPHRDDDFEELQYFPNFYALLTSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDETIALQTKNKLEKNTTDSKSKLFPAPPEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNLGGKTDEAKGKTEAYLEAIRKNIEWLKKHNKKGNKEDYDLSKMRDFINQQADAYVEKGILDKEEANAIKRIYSSL
uniprot
proteins
function
FUNCTION: Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:12388744, PubMed:14597614). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (PubMed:12388744, PubMed:14597614). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q8WXD2, ECO:0000269|PubMed:12388744, ECO:0000269|PubMed:14597614}.
uniprot
proteins
mass_dalton
53183
uniprot
proteins
pubmed
12388744
uniprot
proteins
pubmed
14597614
uniprot
proteins
pubmed
2204688
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7917832
uniprot
proteins
sequence_length
471
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:14597614}; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts. {ECO:0000269|PubMed:14597614}.
uniprot
proteins