Carmil1
entrez
68732
canonical
uniprot
Q6EDY6
canonical
ensembl
ENSMUSG00000021338
resolver
ensp
ENSMUSP00000072662
resolver
ensp
ENSMUSP00000106028
resolver
ensp
ENSMUSP00000219285
resolver
ensp
ENSMUSP00000219286
resolver
ensp
ENSMUSP00000219287
resolver
ensp
ENSMUSP00000219288
resolver
ensp
ENSMUSP00000219290
resolver
ensp
ENSMUSP00000219291
resolver
enst
ENSMUST00000110398
resolver
genesymbol
Carmil1
resolver
genesymbol_syn
Carmil
resolver
genesymbol_syn
Lrrc16
resolver
genesymbol_syn
Lrrc16a
resolver
uniprot
D3Z030
resolver
uniprot
Q5NCM0
resolver
uniprot
Q8BQ45
resolver
uniprot
Q8BRS5
resolver
uniprot
Q91YZ6
resolver
uniprot
Q9CTA1
resolver
uniprot_entry
CARL1_MOUSE
resolver
uniprot_entry
D3Z030_MOUSE
resolver
uniprot_entry
Q9CTA1_MOUSE
resolver
uniprot_sec
Q5NCM0
resolver
uniprot_sec
Q8BQ45
resolver
uniprot_sec
Q8BRS5
resolver
uniprot_sec
Q91YZ6
resolver
amino_acid_sequence
MTDESSDVPRELMESIKDVIGRKIKISVKKKVKLEVKGDRVENKVLVLTSCRAFLLSARIPSKLELTFSYLEIHGVICHKPAQMVVETEKCNMSMKMVSPEDVSEVLAHIGTCLRRIFPGLSPLRIMKKVSMEPSERLASLQALWDSQTLAEPGPCGGFSQMYACVCDWLGFSYKEEVQWDVDTIYLTQDTRELNLQDFSHLEHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRIDFAQKLAGALAHNPNSGLHTINLAGNSLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLCQSLSANPLTASTLTHLDLSGNALRGDDLSHMYNFLAQPNTIVHLDLSNTECSLEMVCSALLRGCLQCLAVLNLSRSVFSHRKGKEVPPSFKQFFSSSLALIQINLSGTKLSPEPLKALLLGLACNHSLKGVSLDLSNCELGHCLRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEDSPLQSLSLADSKLKAEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDAAQALKTNPEKTEEALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRACGGDAIQEDLKAAERLMRDAKNSKTLLPNLYHVGGASWAGASGLSSSPIQETLESMAGEVTRVVDEQLKDLLESMVDAAETLCPNVMRKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDSLSSSHRKLANHFSRLNKSLPQREDLEVELVEEKPVKRAILTVEDLTEVERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIHIEDPPFPSVRQEKRSSGLISELPSEEGRRLEHFTKLRPKRNKKQQPTQAAVCTISILPQDGEQNGLMGRVDEGVDEFFTKKVTKMDCKRSSSRSSDAHELGEGDEKKKRDSRRSGFLNLIKSRSRSERPPTVLMTEELSSPKGAMRSPPVDTTRKEIKAAEHNGAPDRTEEIKTPEPLEEGPAEEAGRAERSDSRGSPQGGRRYVQVMGSGLLAEMKAKQERRAACAQKKLGNDVISQDPSSPVSCNTERLEGGATVPKLQPGLPEARFGSGTPEKNAKAEPRVDGGCRSRSSSSMPTSPKPLLQSPKPSPSARPSIPQKPRTASRPEDTPDSPSGPSSPKVALLPPILKKVSSDKERDGQNSSQSSPRSFSQEASRRSWGPAQEYQEQKQRSSGKDGHQGSKCSDSGEEAEKEFIFV
uniprot
proteins
function
FUNCTION: Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:16054028). {ECO:0000269|PubMed:16054028}.
uniprot
proteins
mass_dalton
151860
uniprot
proteins
mutagenesis
MUTAGEN 991; /note="K->A: Decreased ability to bind heterodimeric capping protein (CP) and to inhibit the actin-capping activity of CP."; /evidence="ECO:0000269|PubMed:16054028"; MUTAGEN 993; /note="R->A: Loss of ability to bind heterodimeric capping protein (CP) and to inhibit the actin-capping activity of CP."; /evidence="ECO:0000269|PubMed:16054028"; MUTAGEN 993; /note="R->E: Loss of ability to bind heterodimeric capping protein (CP) and to inhibit the actin-capping activity of CP."; /evidence="ECO:0000269|PubMed:16054028
uniprot
proteins
protein_family
CARMIL family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16054028
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16054028}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16054028}. Cell membrane {ECO:0000250|UniProtKB:Q5VZK9}. Cell projection, lamellipodium {ECO:0000269|PubMed:16054028}. Note=Found on macropinosomes (By similarity). Colocalized with heterodimeric capping protein (CP) and F-actin in lamellipodia but not with F-actin in stress fibers (PubMed:16054028). {ECO:0000250|UniProtKB:Q5VZK9, ECO:0000269|PubMed:16054028}.
uniprot
proteins