BABAM2
entrez
9577
canonical
uniprot
Q9NXR7
canonical
ensembl
ENSG00000158019
resolver
ensp
ENSP00000339371
resolver
ensp
ENSP00000343412
resolver
ensp
ENSP00000354699
resolver
ensp
ENSP00000368945
resolver
ensp
ENSP00000368953
resolver
ensp
ENSP00000588595
resolver
ensp
ENSP00000638120
resolver
ensp
ENSP00000673408
resolver
ensp
ENSP00000772513
resolver
genesymbol
BABAM2
resolver
genesymbol_syn
BRCC45
resolver
genesymbol_syn
BRE
resolver
hgnc
HGNC:1106
resolver
uniprot
A8K4X1
resolver
uniprot
D6W562
resolver
uniprot
D6W563
resolver
uniprot
Q13880
resolver
uniprot
Q4ZFX8
resolver
uniprot
Q53SD0
resolver
uniprot
Q969X9
resolver
uniprot
Q96P06
resolver
uniprot_entry
BABA2_HUMAN
resolver
uniprot_sec
A8K4X1
resolver
uniprot_sec
D6W562
resolver
uniprot_sec
D6W563
resolver
uniprot_sec
Q13880
resolver
uniprot_sec
Q4ZFX8
resolver
uniprot_sec
Q53SD0
resolver
uniprot_sec
Q969X9
resolver
uniprot_sec
Q96P06
resolver
amino_acid_sequence
MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDAEFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVDFSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPKLYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLMWKDFCFLVHIDLPLFFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAKRAKAYFKTFVPQFQEAAFANGKL
uniprot
proteins
function
FUNCTION: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261748, PubMed:19261749). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:19261748, PubMed:21282113). Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:15465831). {ECO:0000269|PubMed:14636569, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:26195665, ECO:0000305|PubMed:15465831}.
uniprot
proteins
mass_dalton
43552
uniprot
proteins
protein_family
BABAM2 family
uniprot
proteins
pubmed
11676476
uniprot
proteins
pubmed
14636569
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15465831
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17525341
uniprot
proteins
pubmed
19214193
uniprot
proteins
pubmed
19261746
uniprot
proteins
pubmed
19261748
uniprot
proteins
pubmed
19261749
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21282113
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24075985
uniprot
proteins
pubmed
25283148
uniprot
proteins
pubmed
26195665
uniprot
proteins
pubmed
7826398
uniprot
proteins
sequence_length
383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15465831, ECO:0000269|PubMed:24075985}. Nucleus {ECO:0000269|PubMed:15465831, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:24075985}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000269|PubMed:19261748}.
uniprot
proteins