Orc3
entrez
50793
canonical
uniprot
Q9JK30
canonical
ensembl
ENSMUSG00000040044
resolver
ensp
ENSMUSP00000048319
resolver
ensp
ENSMUSP00000103777
resolver
ensp
ENSMUSP00000226996
resolver
ensp
ENSMUSP00000227005
resolver
ensp
ENSMUSP00000227018
resolver
ensp
ENSMUSP00000227030
resolver
genesymbol
Orc3
resolver
genesymbol_syn
Orc3l
resolver
uniprot
A2AMF4
resolver
uniprot
A2AMF5
resolver
uniprot
Q6P8H2
resolver
uniprot
Q8BR83
resolver
uniprot
Q8C395
resolver
uniprot_entry
ORC3_MOUSE
resolver
uniprot_sec
A2AMF4
resolver
uniprot_sec
A2AMF5
resolver
uniprot_sec
Q6P8H2
resolver
uniprot_sec
Q8BR83
resolver
uniprot_sec
Q8C395
resolver
amino_acid_sequence
MHTGPRTMATSSVSKGCFVFKPDFKKRKVFVPIEDYFNNEELDSEDSKLRFETYSLLWQRMKSETEQLQEELNENLFDNLVDFLQKSHPEFQKNSRDWGSQMKFREIPTAALILGVNVTDHDVILRSLTETLQNNVTPYVVSLQAKDCPDVKHFLQKFTSQLMDCCVDRHSKEVTSGKALKKTNYSMDSLCSWYSAVTQKADHKVTIKKRTASGHWRSPPVVLILKSMESFTSKVLQDFITISSQHLHEFPLILIFGIATSPVIIHRLLPHSVSSLLCVELFQSLSCEQHLTVVLDKLLLTPQFPFKLSKKALQVLTNIFLYHDFSIQSFIKGIKLSLLEHFYSQPLSVLCCDLSEAKKRVNVFSVSQCENIRRLPSFRRYVENQPLGKQVALLTNETFLKEKTQSLLEDLHVYHINYFLVLRCLHNFTSSLPKYPLGRQIRELYCTCLEKKIWDSEEYKSALQLLRMLAKDELVSILQRCIEVLDSSTEKQLGNTTQKIKDFLTQFQNLDADSKEEEDACGSQPKGLQKTDLYHLQKSLLEMKELRRTKKPTKFEMLRENVMNFIDNLVRDYLLPPESQPLHEVVYFSAANTLREHLNAAPRIALHTALNNPYYYLKNEELEGCIPNTAPDICIAYKLHLECSLLINLVDWAEAFATVVTAAEKMDANSTVSEEMSEVIHARFIRAVSELELLGFIKPTKQKTDHVARLTWGGC
uniprot
proteins
function
FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000250|UniProtKB:Q9UBD5}.
uniprot
proteins
mass_dalton
82342
uniprot
proteins
post_translational_modification
PTM: Multi-mono-ubiquitinated by OBI1; ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle. {ECO:0000250|UniProtKB:Q9UBD5}.
uniprot
proteins
protein_family
ORC3 family
uniprot
proteins
pubmed
10702681
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15634681
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
715
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UBD5}. Chromosome {ECO:0000250|UniProtKB:Q9UBD5}.
uniprot
proteins