Nr2c1
entrez
22025
canonical
uniprot
Q505F1
canonical
ensembl
ENSMUSG00000005897
resolver
ensp
ENSMUSP00000100927
resolver
ensp
ENSMUSP00000218511
resolver
genesymbol
Nr2c1
resolver
genesymbol_syn
Tr2
resolver
genesymbol_syn
Tr2-11
resolver
uniprot
P97763
resolver
uniprot
Q0VGP8
resolver
uniprot
Q3UIJ7
resolver
uniprot
Q4U1Z4
resolver
uniprot
Q60927
resolver
uniprot
Q62152
resolver
uniprot
Q8VIJ3
resolver
uniprot_entry
NR2C1_MOUSE
resolver
uniprot_sec
P97763
resolver
uniprot_sec
Q0VGP8
resolver
uniprot_sec
Q3UIJ7
resolver
uniprot_sec
Q4U1Z4
resolver
uniprot_sec
Q60927
resolver
uniprot_sec
Q62152
resolver
uniprot_sec
Q8VIJ3
resolver
amino_acid_sequence
MATIEEIAHQIIDQQMGEIVTEQQTGQKIQIVTALDHSTQGKQFILANHEGSTPGKVFLTTPDAAGVNQLFFTSPDLSAPHLQLLTEKSPDQGPNKVFDLCVVCGDKASGRHYGAITCEGCKGFFKRSIRKNLVYSCRGSKDCVINKHHRNRCQYCRLQRCIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLAATPTFVTDSETARSAGLLDSGMFVNIHPSGIKTEPAMLMAPDKAESCQGDLSTLASVVTSLANLGKAKDLSHCGGDMPVVQSLRNGDTSFGAFHHDIQTNGDVSRAFDTLAKALTPGESSACQSPEEGMEGSPHLIAGEPSFVEKEGPLLSESHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHSSLQQDKMSPERRKSLMEHIFKLQEFCNSMVKLCIDGHEYAYLKAIVLFSPDHPGLENMELIERFQEKAYVEFQDYITRTYPDDTYRLSRLLLRLPALRLMNATITEELFFKGLIGNVRIDSVIPHILKMEPADYNSQIIGHSL
uniprot
proteins
function
FUNCTION: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity). Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. {ECO:0000250, ECO:0000269|PubMed:11463856, ECO:0000269|PubMed:12093744, ECO:0000269|PubMed:16130175, ECO:0000269|PubMed:16317770, ECO:0000269|PubMed:17187077, ECO:0000269|PubMed:17389641, ECO:0000269|PubMed:17431400, ECO:0000269|PubMed:17974920, ECO:0000269|PubMed:19131575, ECO:0000269|PubMed:8530418, ECO:0000269|PubMed:8858600, ECO:0000269|PubMed:9071982, ECO:0000269|PubMed:9774688}.
uniprot
proteins
mass_dalton
65476
uniprot
proteins
mutagenesis
MUTAGEN 167; /note="K->A: No effect on sumoylation."; /evidence="ECO:0000269|PubMed:17187077"; MUTAGEN 170; /note="S->A: No effect on sumoylation nor on DNA-binding and little effect on binding KAT2B. Greatly reduced DNA-binding, binding to KAT2B and activation of the RARB promoter; when associated with A-185."; /evidence="ECO:0000269|PubMed:16317770, ECO:0000269|PubMed:18682553"; MUTAGEN 185; /note="S->A: No effect on sumoylation and little effect on binding KAT2B. Some reduced DNA-binding. Greatly reduced DNA-binding, binding to KAT2B and activation of the RARB promoter; when associated with A-170."; /evidence="ECO:0000269|PubMed:16317770, ECO:0000269|PubMed:18682553"; MUTAGEN 203; /note="S->A: No effect on sumoylation."; /evidence="ECO:0000269|PubMed:18682553"; MUTAGEN 208; /note="T->A: No effect on sumoylation."; /evidence="ECO:0000269|PubMed:18682553"; MUTAGEN 210; /note="T->A: Abolishes sumoylation. No repression of OCT4 gene expression with or without retinoic acid and enhanced interaction with KAT2B and HDAC3. Abolishes interaction with HDAC3 and PML association; when associated with R-238."; /evidence="ECO:0000269|PubMed:18682553"; MUTAGEN 210; /note="T->E: Sumoylated. Repressed OCT4 gene expression. Enhanced interaction with KAT2B; when associated with R-238."; /evidence="ECO:0000269|PubMed:18682553"; MUTAGEN 238; /note="K->A: Abolishes sumoylation. Strongly associated with PML nuclear bodies. No effect on activation of OCT4 but activation not suppressed by additional SUMO1. Increased binding to KAT2B and reduced binding to NRIP1. Abolishes PML association; when associated with A-210."; /evidence="ECO:0000269|PubMed:17187077, ECO:0000269|PubMed:18682553"; MUTAGEN 238; /note="K->R: Abolishes sumoylation. No effect on activation of OCT4 but activation not suppressed by additional SUMO1. Enhanced interaction with KAT2B; when associated with A-210 or E-210."; /evidence="ECO:0000269|PubMed:17187077, ECO:0000269|PubMed:18682553"; MUTAGEN 240; /note="E->A: Abolishes sumoylation."; /evidence="ECO:0000269|PubMed:17187077"; MUTAGEN 461; /note="S->A: Little effect on PKC-stimulated protein stability nor on activation of RARB reporter."; /evidence="ECO:0000269|PubMed:18682553"; MUTAGEN 461; /note="S->A: No effect on sumoylation."; /evidence="ECO:0000269|PubMed:18682553"; MUTAGEN 568; /note="S->A: Greatly reduced PKC-stimulated protein stability and activation of RARB reporter."; /evidence="ECO:0000269|PubMed:18682553"; MUTAGEN 568; /note="S->A: No effect on sumoylation."; /evidence="ECO:0000269|PubMed:18682553"; MUTAGEN 575; /note="K->R: No effect on sumoylation."; /evidence="ECO:0000269|PubMed:17187077
uniprot
proteins
post_translational_modification
PTM: Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression.; PTM: Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-210, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-568 by PKC is important for protein stability and function as activator of RARB. {ECO:0000269|PubMed:16130175, ECO:0000269|PubMed:18682553}.
uniprot
proteins
protein_family
NR2 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
11463856
uniprot
proteins
pubmed
12052874
uniprot
proteins
pubmed
12093744
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16130175
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16317770
uniprot
proteins
pubmed
17187077
uniprot
proteins
pubmed
17389641
uniprot
proteins
pubmed
17431400
uniprot
proteins
pubmed
17974920
uniprot
proteins
pubmed
18682553
uniprot
proteins
pubmed
19131575
uniprot
proteins
pubmed
19204783
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8530418
uniprot
proteins
pubmed
8595902
uniprot
proteins
pubmed
8858600
uniprot
proteins
pubmed
9071982
uniprot
proteins
pubmed
9369481
uniprot
proteins
pubmed
9504722
uniprot
proteins
pubmed
9694834
uniprot
proteins
pubmed
9774688
uniprot
proteins
sequence_length
590
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body. Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-210 phosphorylation, to PML bodies for subsequent sumoylation.
uniprot
proteins