SLC38A2
entrez
54407
canonical
uniprot
Q96QD8
canonical
ensembl
ENSG00000134294
resolver
ensp
ENSP00000256689
resolver
ensp
ENSP00000482873
resolver
genesymbol
SLC38A2
resolver
genesymbol_syn
ATA2
resolver
genesymbol_syn
KIAA1382
resolver
genesymbol_syn
SAT2
resolver
genesymbol_syn
SNAT2
resolver
hgnc
HGNC:13448
resolver
uniprot
Q6IA88
resolver
uniprot
Q6ZMG2
resolver
uniprot
Q8NHT5
resolver
uniprot
Q9HAV3
resolver
uniprot
Q9NVA8
resolver
uniprot
Q9P2G5
resolver
uniprot_entry
Q8NHT5_HUMAN
resolver
uniprot_entry
S38A2_HUMAN
resolver
uniprot_sec
Q6IA88
resolver
uniprot_sec
Q6ZMG2
resolver
uniprot_sec
Q9HAV3
resolver
uniprot_sec
Q9NVA8
resolver
uniprot_sec
Q9P2G5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-methyl-D-glucamine (PubMed:10930503). Inhibited by choline. Allosteric regulation of sodium ions binding by pH (By similarity). {ECO:0000250|UniProtKB:Q9JHE5, ECO:0000269|PubMed:10930503}.
uniprot
proteins
amino_acid_sequence
MKKAEMGRFSISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKKKYETEFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGYTSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDSCRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTHLLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIKLVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH
uniprot
proteins
function
FUNCTION: Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10930503, PubMed:15774260, PubMed:15922329, PubMed:16621798). The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier (PubMed:10930503, PubMed:15774260). May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (By similarity). Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity). Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (By similarity). {ECO:0000250|UniProtKB:Q8CFE6, ECO:0000250|UniProtKB:Q9JHE5, ECO:0000269|PubMed:10930503, ECO:0000269|PubMed:15774260, ECO:0000269|PubMed:15922329, ECO:0000269|PubMed:16621798}.
uniprot
proteins
mass_dalton
56026
uniprot
proteins
post_translational_modification
PTM: Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2. {ECO:0000269|PubMed:26374858}.
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
10930503
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14623874
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15774260
uniprot
proteins
pubmed
15922329
uniprot
proteins
pubmed
16616430
uniprot
proteins
pubmed
16621798
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26374858
uniprot
proteins
sequence_length
506
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9JHE5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JHE5}. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. {ECO:0000250|UniProtKB:Q9JHE5}.
uniprot
proteins
transmembrane_region
TRANSMEM 77..96; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9JHE5, ECO:0000255"; TRANSMEM 159..177; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9JHE5, ECO:0000255"; TRANSMEM 189..209; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9JHE5, ECO:0000255"; TRANSMEM 218..238; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9JHE5, ECO:0000255"; TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9JHE5, ECO:0000255"; TRANSMEM 330..350; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 372..392; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 414..434; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 437..457; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9JHE5, ECO:0000255"; TRANSMEM 473..495; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9JHE5, ECO:0000255
uniprot
proteins