SPTLC3
entrez
55304
canonical
uniprot
Q9NUV7
canonical
ensembl
ENSG00000172296
resolver
ensp
ENSP00000381968
resolver
ensp
ENSP00000791106
resolver
genesymbol
SPTLC3
resolver
genesymbol_syn
C20orf38
resolver
genesymbol_syn
SPTLC2L
resolver
hgnc
HGNC:16253
resolver
uniprot
A2A2I4
resolver
uniprot
B9EK64
resolver
uniprot
Q05DQ8
resolver
uniprot
Q5T1U4
resolver
uniprot
Q9H1L1
resolver
uniprot
Q9H1Z0
resolver
uniprot_entry
SPTC3_HUMAN
resolver
uniprot_sec
A2A2I4
resolver
uniprot_sec
B9EK64
resolver
uniprot_sec
Q05DQ8
resolver
uniprot_sec
Q5T1U4
resolver
uniprot_sec
Q9H1L1
resolver
uniprot_sec
Q9H1Z0
resolver
activity_regulation
ACTIVITY REGULATION: SPT complex catalytic activity is negatively regulated by ORMDL proteins, including ORMDL3, in the presence of ceramides (By similarity). This mechanism allows to maintain ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (Probable). {ECO:0000250|UniProtKB:O15270, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MANPGGGAVCNGKLHNHKKQSNGSQSRNCTKNGIVKEAQQNGKPHFYDKLIVESFEEAPLHVMVFTYMGYGIGTLFGYLRDFLRNWGIEKCNAAVERKEQKDFVPLYQDFENFYTRNLYMRIRDNWNRPICSAPGPLFDLMERVSDDYNWTFRFTGRVIKDVINMGSYNFLGLAAKYDESMRTIKDVLEVYGTGVASTRHEMGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPALVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVIYGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFARHMLEKKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSARPELYDETSFELED
uniprot
proteins
ec_number
2.3.1.50
uniprot
proteins
function
FUNCTION: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases (PubMed:19416851, PubMed:19648650). The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (PubMed:19416851). The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (PubMed:19416851, PubMed:19648650). {ECO:0000269|PubMed:19416851, ECO:0000269|PubMed:19648650}.
uniprot
proteins
mass_dalton
62049
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:19416851, ECO:0000269|PubMed:19648650}.
uniprot
proteins
protein_family
Class-II pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17023427
uniprot
proteins
pubmed
19416851
uniprot
proteins
pubmed
19648650
uniprot
proteins
sequence_length
552
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:19416851}; Single-pass membrane protein {ECO:0000305|PubMed:19416851}.
uniprot
proteins
transmembrane_region
TRANSMEM 59..79; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins