FBXL7
entrez
23194
canonical
uniprot
Q9UJT9
canonical
ensembl
ENSG00000183580
resolver
ensp
ENSP00000329632
resolver
ensp
ENSP00000423630
resolver
ensp
ENSP00000425184
resolver
genesymbol
FBXL7
resolver
genesymbol_syn
FBL6
resolver
genesymbol_syn
FBL7
resolver
genesymbol_syn
KIAA0840
resolver
hgnc
HGNC:13604
resolver
uniprot
B9EGF1
resolver
uniprot
D6RDY7
resolver
uniprot
O94926
resolver
uniprot_entry
FBXL7_HUMAN
resolver
uniprot_sec
B9EGF1
resolver
uniprot_sec
D6RDY7
resolver
uniprot_sec
O94926
resolver
amino_acid_sequence
MGANNGKQYGSEGKGSSSISSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:25778398). During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (By similarity). It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 (PubMed:25778398, PubMed:28218735). {ECO:0000250|UniProtKB:Q5BJ29, ECO:0000269|PubMed:25778398, ECO:0000269|PubMed:28218735}.
uniprot
proteins
mass_dalton
54575
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:25778398, ECO:0000269|PubMed:28218735}.
uniprot
proteins
protein_family
FBXL7 family
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
10531035
uniprot
proteins
pubmed
10945468
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25778398
uniprot
proteins
pubmed
28218735
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5BJ29}. Note=Localizes to the centrosome during spindle formation. {ECO:0000250|UniProtKB:Q5BJ29}.
uniprot
proteins