C1GALT1
entrez
56913
canonical
uniprot
Q9NS00
canonical
ensembl
ENSG00000106392
resolver
ensp
ENSP00000223122
resolver
ensp
ENSP00000389176
resolver
ensp
ENSP00000580803
resolver
ensp
ENSP00000580808
resolver
ensp
ENSP00000580816
resolver
ensp
ENSP00000580827
resolver
ensp
ENSP00000603110
resolver
ensp
ENSP00000603115
resolver
ensp
ENSP00000603117
resolver
ensp
ENSP00000603118
resolver
ensp
ENSP00000603123
resolver
genesymbol
C1GALT1
resolver
hgnc
HGNC:24337
resolver
uniprot
A0A024RA32
resolver
uniprot
Q96QH4
resolver
uniprot
Q9BTU1
resolver
uniprot_entry
A0A024RA32_HUMAN
resolver
uniprot_entry
C1GLT_HUMAN
resolver
uniprot_sec
Q96QH4
resolver
uniprot_sec
Q9BTU1
resolver
amino_acid_sequence
MASKSWLNFLTFLCGSAIGFLLCSQLFSILLGEKVDTQPNVLHNDPHARHSDDNGQNHLEGQMNFNADSSQHKDENTDIAENLYQKVRILCWVMTGPQNLEKKAKHVKATWAQRCNKVLFMSSEENKDFPAVGLKTKEGRDQLYWKTIKAFQYVHEHYLEDADWFLKADDDTYVILDNLRWLLSKYDPEEPIYFGRRFKPYVKQGYMSGGAGYVLSKEALKRFVDAFKTDKCTHSSSIEDLALGRCMEIMNVEAGDSRDTIGKETFHPFVPEHHLIKGYLPRTFWYWNYNYYPPVEGPGCCSDLAVSFHYVDSTTMYELEYLVYHLRPYGYLYRYQPTLPERILKEISQANKNEDTKVKLGNP
uniprot
proteins
ec_number
2.4.1.122
uniprot
proteins
function
FUNCTION: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins (PubMed:11677243). Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development (By similarity). {ECO:0000250|UniProtKB:Q7K237, ECO:0000250|UniProtKB:Q9JJ06, ECO:0000269|PubMed:11677243}.
uniprot
proteins
mass_dalton
42203
uniprot
proteins
mutagenesis
MUTAGEN 140; /note="R->A: Reduced activity."; /evidence="ECO:0000269|PubMed:35504880"; MUTAGEN 201; /note="Y->A: Reduced activity."; /evidence="ECO:0000269|PubMed:35504880"; MUTAGEN 206; /note="Y->A: Reduced activity."; /evidence="ECO:0000269|PubMed:35504880"; MUTAGEN 240; /note="D->A: Inactive."; /evidence="ECO:0000269|PubMed:35504880"; MUTAGEN 285; /note="W->A: Inactive."; /evidence="ECO:0000269|PubMed:35504880"; MUTAGEN 310; /note="Y->A: Reduced activity."; /evidence="ECO:0000269|PubMed:35504880
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:11677243}.
uniprot
proteins
protein_family
Beta3-Gal-T subfamily
uniprot
proteins
protein_family
Glycosyltransferase 31 family
uniprot
proteins
pubmed
11677243
uniprot
proteins
pubmed
12464682
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17228361
uniprot
proteins
pubmed
19357720
uniprot
proteins
pubmed
35504880
uniprot
proteins
sequence_length
363
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9JJ05}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..29; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins