Reg3a
entrez
19694
canonical
uniprot
O09037
canonical
ensembl
ENSMUSG00000079516
resolver
ensp
ENSMUSP00000098829
resolver
enst
ENSMUST00000101272
resolver
genesymbol
Reg3a
resolver
genesymbol_syn
Pap2
resolver
uniprot
Q794C6
resolver
uniprot_entry
Q794C6_MOUSE
resolver
uniprot_entry
REG3A_MOUSE
resolver
amino_acid_sequence
MLPHLVLNSISWMLLSCLLFVFQVQGEDFQKEVPSPRTSCPMGYKAYRSHCYALVMTPKSWFQADLVCQKRPSGHLVSILSGGEASFVSSLVNGRVDNYQDIWIGLHDPTMGQQPNGGGWEWSNSDVLNYLNWDGDPSSTVNRGHCGSLTASSGFLKWGDYYCDGTLPFVCKFKQ
uniprot
proteins
disease_involvement
DISEASE: Note=Overexpressed during the acute phase of pancreatitis.
uniprot
proteins
function
FUNCTION: Bactericidal C-type lectin. The lack of the EPN motif may explain its inability to bind peptidoglycan. {ECO:0000269|PubMed:20382864}.; FUNCTION: Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway (By similarity). In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF (PubMed:22727489). In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation (PubMed:36240759). {ECO:0000250|UniProtKB:Q06141, ECO:0000269|PubMed:22727489, ECO:0000269|PubMed:36240759}.
uniprot
proteins
mass_dalton
19539
uniprot
proteins
post_translational_modification
PTM: Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. {ECO:0000250|UniProtKB:Q06141}.
uniprot
proteins
pubmed
20382864
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22727489
uniprot
proteins
pubmed
36240759
uniprot
proteins
pubmed
9055810
uniprot
proteins
sequence_length
175
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q06141}. Note=Found in the apical region of pancreatic acinar cells. {ECO:0000250|UniProtKB:Q06141}.
uniprot
proteins