TRPC6
entrez
7225
canonical
uniprot
Q9Y210
canonical
ensembl
ENSG00000137672
resolver
ensp
ENSP00000340913
resolver
ensp
ENSP00000343672
resolver
genesymbol
TRPC6
resolver
genesymbol_syn
TRP6
resolver
hgnc
HGNC:12338
resolver
uniprot
Q52M59
resolver
uniprot
Q9HCW3
resolver
uniprot
Q9NQA8
resolver
uniprot
Q9NQA9
resolver
uniprot_entry
TRPC6_HUMAN
resolver
uniprot_sec
Q52M59
resolver
uniprot_sec
Q9HCW3
resolver
uniprot_sec
Q9NQA8
resolver
uniprot_sec
Q9NQA9
resolver
activity_regulation
ACTIVITY REGULATION: Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. {ECO:0000269|PubMed:9930701}.
uniprot
proteins
amino_acid_sequence
MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKLSMEPNQEETNR
uniprot
proteins
disease_involvement
DISEASE: Focal segmental glomerulosclerosis 2 (FSGS2) [MIM:603965]: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. {ECO:0000269|PubMed:15879175, ECO:0000269|PubMed:15924139, ECO:0000269|PubMed:19458060, ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:20798252, ECO:0000269|PubMed:21511817, ECO:0000269|PubMed:21734084, ECO:0000269|PubMed:22732337, ECO:0000269|PubMed:23014460, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Non-selective, calcium-permeable cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Mediates calcium entry following G(q)-coupled receptor or receptor tyrosine kinase activation, which triggers phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositides and production of diacylglycerol (DAG) that directly activates TRPC6 (PubMed:26892346). Does not appear to be activated by depletion of intracellular calcium stores (PubMed:9930701). Mediates depolarization of intrinsically photosensitive retinal ganglion cells (ipRGCs) in response to light-induced melanopsin (OPN4)-mediated phototransduction via G(q)-PLC signaling, likely by forming heteromeric TRPC6-TRPC7 channels (By similarity). {ECO:0000250|UniProtKB:Q61143, ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}.
uniprot
proteins
mass_dalton
106326
uniprot
proteins
mutagenesis
MUTAGEN 110; /note="N->H: Increases calcium ion transport."; /evidence="ECO:0000269|PubMed:26892346"; MUTAGEN 125; /note="N->A: No effect on RNF24-binding; when associated with A-127; A-128 and A-130."; /evidence="ECO:0000269|PubMed:17850865"; MUTAGEN 127; /note="N->A: No effect on RNF24-binding; when associated with A-125; A-128 and A-130."; /evidence="ECO:0000269|PubMed:17850865"; MUTAGEN 128; /note="C->A: No effect on RNF24-binding; when associated with A-125; A-127 and A-130."; /evidence="ECO:0000269|PubMed:17850865"; MUTAGEN 130; /note="D->A: No effect on RNF24-binding; when associated with A-125; A-127 and A-128."; /evidence="ECO:0000269|PubMed:17850865"; MUTAGEN 132; /note="M->T: Increases cation channel activity. Increases significantly inward and outward currents and does not show channel inactivation. Increases calcium ion transport."; /evidence="ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:26892346"; MUTAGEN 561; /note="N->Q: Constitutively activates channel."; /evidence="ECO:0000269|PubMed:12970363"; MUTAGEN 755..757; /note="EEG->KKR: Decreases calcium ion transport."; /evidence="ECO:0000269|PubMed:26892346"; MUTAGEN 755..756; /note="EE->KK: Increases calcium ion transport."; /evidence="ECO:0000269|PubMed:26892346"; MUTAGEN 826..827; /note="KK->EE: Decreases calcium ion transport."; /evidence="ECO:0000269|PubMed:26892346"; MUTAGEN 889; /note="Q->K: Increases calcium transport. Increases calcium ion transport."; /evidence="ECO:0000269|PubMed:19124028, ECO:0000269|PubMed:26892346
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FYN, leading to an increase of TRPC6 channel activity. {ECO:0000250|UniProtKB:Q61143}.
uniprot
proteins
protein_family
STrpC subfamily
uniprot
proteins
protein_family
TRPC6 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
10816590
uniprot
proteins
pubmed
12970363
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15757897
uniprot
proteins
pubmed
15879175
uniprot
proteins
pubmed
15924139
uniprot
proteins
pubmed
17850865
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
19124028
uniprot
proteins
pubmed
19458060
uniprot
proteins
pubmed
19936226
uniprot
proteins
pubmed
20798252
uniprot
proteins
pubmed
21511817
uniprot
proteins
pubmed
21734084
uniprot
proteins
pubmed
22732337
uniprot
proteins
pubmed
23014460
uniprot
proteins
pubmed
23291369
uniprot
proteins
pubmed
26892346
uniprot
proteins
pubmed
9925922
uniprot
proteins
pubmed
9930701
uniprot
proteins
sequence_length
931
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 439..459; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 488..508; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 522..542; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 593..613; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 637..657; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 707..727; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins