PTPRK
entrez
5796
canonical
uniprot
Q15262
canonical
ensembl
ENSG00000152894
resolver
ensembl
ENSG00000273993
resolver
ensp
ENSP00000357196
resolver
ensp
ENSP00000357198
resolver
ensp
ENSP00000357209
resolver
ensp
ENSP00000432973
resolver
genesymbol
PTPRK
resolver
genesymbol_syn
PTPK
resolver
hgnc
HGNC:9674
resolver
uniprot
B2RTQ8
resolver
uniprot
B4DHC3
resolver
uniprot
B7ZMG0
resolver
uniprot
Q14763
resolver
uniprot
Q59EZ1
resolver
uniprot
Q5TG10
resolver
uniprot
Q5TG11
resolver
uniprot
Q86WJ2
resolver
uniprot_entry
B4DHC3_HUMAN
resolver
uniprot_entry
PTPRK_HUMAN
resolver
uniprot_entry
Q59EZ1_HUMAN
resolver
uniprot_entry
Q86WJ2_HUMAN
resolver
uniprot_sec
B2RTQ8
resolver
uniprot_sec
B7ZMG0
resolver
uniprot_sec
Q14763
resolver
uniprot_sec
Q5TG10
resolver
uniprot_sec
Q5TG11
resolver
amino_acid_sequence
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. {ECO:0000269|PubMed:19836242}.
uniprot
proteins
mass_dalton
162102
uniprot
proteins
post_translational_modification
PTM: This protein undergoes proteolytic processing.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 2B subfamily
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19167335
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19836242
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8663237
uniprot
proteins
pubmed
9047348
uniprot
proteins
sequence_length
1439
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 753..774; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins