SPINDOC
entrez
144097
canonical
uniprot
Q9BUA3
canonical
ensembl
ENSG00000168005
resolver
ensp
ENSP00000294244
resolver
ensp
ENSP00000521138
resolver
ensp
ENSP00000521139
resolver
ensp
ENSP00000521140
resolver
ensp
ENSP00000639080
resolver
ensp
ENSP00000724213
resolver
enst
ENST00000294244
resolver
genesymbol
SPINDOC
resolver
genesymbol_syn
C11orf84
resolver
hgnc
HGNC:25115
resolver
uniprot
Q68CV7
resolver
uniprot
Q6PHS2
resolver
uniprot
Q96IH0
resolver
uniprot_entry
SPNDC_HUMAN
resolver
uniprot_sec
Q68CV7
resolver
uniprot_sec
Q6PHS2
resolver
uniprot_sec
Q96IH0
resolver
amino_acid_sequence
MALKAEGAALDCFEVTLKCEEGEDEEEAMVVAVIPRPEPMLRVTQQEKTPPPRPSPLEAGSDGCEEPKQQVSWEQEFLVGSSPGGSGRALCMVCGAEIRAPSADTARSHILEQHPHTLDLSPSEKSNILEAWSEGVALLQDVRAEQPSPPNSDSGQDAHPDPDANPDAARMPAEIVVLLDSEDNPSLPKRSRPRGLRPLELPAVPATEPGNKKPRGQRWKEPPGEEPVRKKRGRPMTKNLDPDPEPPSPDSPTETFAAPAEVRHFTDGSFPAGFVLQLFSHTQLRGPDSKDSPKDREVAEGGLPRAESPSPAPPPGLRGTLDLQVIRVRMEEPPAVSLLQDWSRHPQGTKRVGAGDTSDWPTVLSESSTTVAGKPEKGNGV
uniprot
proteins
function
FUNCTION: Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (PubMed:33574238). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271). {ECO:0000269|PubMed:33574238, ECO:0000269|PubMed:34737271}.
uniprot
proteins
mass_dalton
41037
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29061846
uniprot
proteins
pubmed
33574238
uniprot
proteins
pubmed
34737271
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29061846}. Chromosome {ECO:0000269|PubMed:34737271}. Note=Colocalizes with PARP1 to sites of DNA damage. {ECO:0000269|PubMed:34737271}.
uniprot
proteins