SLC18A1
entrez
6570
canonical
uniprot
P54219
canonical
ensembl
ENSG00000036565
resolver
ensp
ENSP00000265808
resolver
ensp
ENSP00000276373
resolver
ensp
ENSP00000387549
resolver
ensp
ENSP00000413361
resolver
ensp
ENSP00000428001
resolver
ensp
ENSP00000429664
resolver
ensp
ENSP00000569006
resolver
enst
ENST00000517776
resolver
genesymbol
SLC18A1
resolver
genesymbol_syn
VAT1
resolver
genesymbol_syn
VMAT1
resolver
hgnc
HGNC:10934
resolver
uniprot
E9PDJ5
resolver
uniprot
F6QTZ9
resolver
uniprot
Q96GL6
resolver
uniprot
Q9BRE4
resolver
uniprot_entry
F6QTZ9_HUMAN
resolver
uniprot_entry
Q96GL6_HUMAN
resolver
uniprot_entry
VMAT1_HUMAN
resolver
uniprot_sec
E9PDJ5
resolver
uniprot_sec
Q9BRE4
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform 1]: Strongly inhibited by reserpine. Also inhibited to a lesser extent by ketanserin and fenfluramine. Not significantly inhibited by tetrabenazine. {ECO:0000269|PubMed:8643547}.
uniprot
proteins
amino_acid_sequence
MLRTILDAPQRLLKEGRASRQLVLVVVFVALLLDNMLFTVVVPIVPTFLYDMEFKEVNSSLHLGHAGSSPHALASPAFSTIFSFFNNNTVAVEESVPSGIAWMNDTASTIPPPATEAISAHKNNCLQGTGFLEEEITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIVYAPLCYYLRSPPAKEEKLAILSQDCPMETRMYATQKPTKEFPLGEDSDEEPDHEE
uniprot
proteins
function
FUNCTION: [Isoform 1]: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin (PubMed:16326835, PubMed:23337945, PubMed:8643547). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli (PubMed:23337945). {ECO:0000269|PubMed:16326835, ECO:0000269|PubMed:23337945, ECO:0000269|PubMed:8643547}.; FUNCTION: [Isoform 2]: Unable to uptake serotonin. {ECO:0000269|PubMed:16326835}.
uniprot
proteins
mass_dalton
56257
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Vesicular transporter family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16326835
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
23337945
uniprot
proteins
pubmed
8643547
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:8643547}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q8R090}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:16326835}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16326835}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..158; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 198..218; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 228..250; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 257..279; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 300..319; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 336..360; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 366..386; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 398..418; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 423..443; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 449..470; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins