Hapstr1
entrez
69053
canonical
uniprot
Q14AM7
canonical
ensembl
ENSMUSG00000022507
resolver
ensp
ENSMUSP00000023150
resolver
enst
ENSMUST00000023150
resolver
genesymbol
Hapstr1
resolver
uniprot
Q9D905
resolver
uniprot_entry
HAPR1_MOUSE
resolver
uniprot_sec
Q9D905
resolver
amino_acid_sequence
MEERKEEGEAEIQEHGPEHWFSKWERQCLAEAEQDEQLSPELQEEAAAAAQPEHKQQKLWHLFQNSATAVAQLYKDRVCQQPGLSLWVPFQNAATAVTNLYKESVDTHQRSFDIGIQIGYQRRNKDVLAWVKKRRRTIRREDLISFLCGKVPPPRNSRAPPRLTVVSPNRATSTETSSSVETDLQPFREAIALHGLSGAMASISVRSSTPGSPTHVSSGPNASRRRNGLHDVDLNTFITEEMALHLDNGGTRKRTSAQCGDVITDSPTHKRNRML
uniprot
proteins
function
FUNCTION: Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs. Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage. May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1. {ECO:0000250|UniProtKB:Q14CZ0}.
uniprot
proteins
mass_dalton
30940
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by HUWE1. Promotes HAPSTR1 degradation through polyubiquitination. {ECO:0000250|UniProtKB:Q14CZ0}.
uniprot
proteins
protein_family
HAPSTR1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q14CZ0}. Cytoplasm {ECO:0000250|UniProtKB:Q14CZ0}.
uniprot
proteins