Scn9a
entrez
78956
canonical
uniprot
O08562
canonical
ensembl
ENSRNOG00000006639
resolver
ensp
ENSRNOP00000059170
resolver
genesymbol
Scn9a
resolver
uniprot_entry
SCN9A_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the conotoxin GVIIJ. {ECO:0000305|PubMed:24497506}.
uniprot
proteins
amino_acid_sequence
MAMLPPPGPQSFVHFTKQSLALIEQRISEEKAKEHKDEKKDDEEEGPKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKAIFRFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTLSNPPEWTKNVEYTFTGIYTFESLIKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRKELEENETLESIMNTAESEEELKKYFYYLEGSKDALLCGFSTDSGQCPEGYICVKAGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEFTSIGRSRIMGLSESSSETSRLSSKSAKERRNRRKKKKQKMSSGEEKGDDEKLSKSGSEESIRKKSFHLGVEGHHRTREKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDLGSETEFADDEHSIFGDNESRRGSLFVPHRPRERRSSNISQASRSPPVLPVNGKMHSAVDCNGVVSLVDGPSALMLPNGQLLPEVIIDKATSDDSGTTNQMRKKRLSSSYFLSEDMLNDPHLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHTFLIWNCSPYWIKFKKLIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAVGNLIFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLIELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINVDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDTDANNLQIAVARIKRGINYVKQTLREFILKSFSKKPKGSKDTKRTADPNNKKENYISNRTLAEMSKDHNFLKEKDRISGYGSSLDKSFMDENDYQSFIHNPSLTVTVPIAPGESDLEIMNTEELSSDSDSDYSKEKRNRSSSSECSTVDNPLPGEEEAEAEPVNADEPEACFTDGCVRRFPCCQVNVDSGKGKVWWTIRKTCYRIVEHSWFESFIVLMILLSSGALAFEDIYIEKKKTIKIILEYADKIFTYIFILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECVNTTDGSRFPTSQVANRSECFALMNVSGNVRWKNLKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSVNVNEQPKYEYSLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGCIFDLVTNQAFDITIMVLICLNMVTMMVEKEGQTEYMDYVLHWINMVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGEGGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEEVSATIIQRAYRRYRLRQHVKNISSIYIKDGDRDDDLPNKEDTVFDNVNENSSPEKTDVTASTISPPSYDSVTKPDQEKYETDKTEKEDKEKDESRK
uniprot
proteins
function
FUNCTION: Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes (By similarity). Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient (By similarity). The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:15123669). Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain (By similarity). {ECO:0000250|UniProtKB:Q15858, ECO:0000269|PubMed:15123669}.
uniprot
proteins
mass_dalton
226039
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-1488 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents. {ECO:0000250|UniProtKB:Q15858}.; PTM: Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4. {ECO:0000250|UniProtKB:Q62205}.; PTM: Ubiquitinated by NEDD4L; which may promote its endocytosis. {ECO:0000250|UniProtKB:Q62205}.
uniprot
proteins
protein_family
Nav1.7/SCN9A subfamily
uniprot
proteins
protein_family
Sodium channel (TC 1.A.1.10) family
uniprot
proteins
pubmed
15123669
uniprot
proteins
pubmed
24497506
uniprot
proteins
pubmed
9037087
uniprot
proteins
pubmed
9169448
uniprot
proteins
sequence_length
1984
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q15858}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q15858}. Cell projection, neuron projection {ECO:0000269|PubMed:9037087}. Cell projection, axon {ECO:0000250|UniProtKB:Q15858}. Note=Localizes to neuron terminals (PubMed:9037087). Also detected at Nodes of Ranvier (By similarity). {ECO:0000250|UniProtKB:Q15858, ECO:0000269|PubMed:9037087}.
uniprot
proteins
transmembrane_region
TRANSMEM 126..145; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 151..172; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 186..204; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 211..227; /note="Helical; Name=S4 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 242..267; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 377..402; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 745..761; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 771..795; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 805..821; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 831..847; /note="Helical; Name=S4 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 865..887; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 940..966; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 1186..1210; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 1223..1248; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 1251..1276; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 1286..1302; /note="Helical; Name=S4 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 1316..1340; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 1430..1455; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 1513..1532; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 1544..1565; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 1575..1596; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 1606..1625; /note="Helical; Name=S4 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 1639..1661; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q15858"; TRANSMEM 1732..1757; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q15858
uniprot
proteins