Slc11a2
entrez
25715
canonical
uniprot
O54902
canonical
ensembl
ENSRNOG00000019550
resolver
ensp
ENSRNOP00000026531
resolver
ensp
ENSRNOP00000091312
resolver
enst
ENSRNOT00000026531
resolver
enst
ENSRNOT00000093762
resolver
genesymbol
Slc11a2
resolver
genesymbol_syn
Dct1
resolver
genesymbol_syn
Dmt1
resolver
genesymbol_syn
Nramp2
resolver
uniprot
A0A140TAD8
resolver
uniprot
A0A8I6ABD7
resolver
uniprot
O35172
resolver
uniprot_entry
A0A140TAD8_RAT
resolver
uniprot_entry
A0A8I6ABD7_RAT
resolver
uniprot_entry
NRAM2_RAT
resolver
uniprot_sec
O35172
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 2-(3-carbamimidoylsulfanylmethyl-benzyl)-isothiourea. {ECO:0000269|PubMed:29317744}.
uniprot
proteins
amino_acid_sequence
MVLDPEEKIPDDGASGDHGDSASLGAINPAYSNSSLPHSTGDSEEPFTTYFDEKIPIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWVLLLATIVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRIILWLMVELAIIGSDMQEVIGSAIAINLLSAGRVPLYGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLRGMFVPSCSGCHTPQVEQAVGIVGAVIMPHNMYLHSALVKSRQVNRANKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFEKTNEQVVEVCRNSSSPHADLFPNDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVILTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSEFSNGIGWRIAGGILVLLVCSINMYFVVVYVQELGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGLSFLDCGRSYHLGLTARPEIYLLNTVDAVSLVSR
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Slc11a2 are the cause of microcytic anemia (Belgrade or b). Homozygous b/b rats have hypochromic microcytic anemia due to severe defects in intestinal iron absorption and erythroid iron utilization.
uniprot
proteins
function
FUNCTION: Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:16091957, PubMed:9242408). Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (By similarity) (PubMed:16091957, PubMed:29317744, PubMed:9242408). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity) (PubMed:9242408). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (PubMed:29317744). Can mediate uncoupled fluxes of either protons or metal ions. {ECO:0000250|UniProtKB:P49281, ECO:0000250|UniProtKB:P49282, ECO:0000269|PubMed:16091957, ECO:0000269|PubMed:29317744, ECO:0000269|PubMed:9242408}.
uniprot
proteins
mass_dalton
62277
uniprot
proteins
mutagenesis
MUTAGEN 267; /note="H->A: Reduces expression at the plasma membrane. Does not affect H(+)-coupled Fe(2+) transport."; /evidence="ECO:0000269|PubMed:16091957"; MUTAGEN 267; /note="H->D,N: Impairs expression at the plasma membrane."; /evidence="ECO:0000269|PubMed:16091957"; MUTAGEN 272; /note="H->A: Uncouples Fe(2+) and H(+) fluxes. Mediates facilitative Fe(2+) transport independently of pH gradient."; /evidence="ECO:0000269|PubMed:16091957"; MUTAGEN 272; /note="H->R: Loss of proton-coupled Fe(2+) transporter activity."; /evidence="ECO:0000269|PubMed:16091957
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by WWP2. {ECO:0000250|UniProtKB:P49282}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:P49281}.
uniprot
proteins
protein_family
NRAMP (TC 2.A.55) family
uniprot
proteins
pubmed
16091957
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24448823
uniprot
proteins
pubmed
29317744
uniprot
proteins
pubmed
9242408
uniprot
proteins
pubmed
9448300
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P49282}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:P49281}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000250|UniProtKB:P49282}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:P49281}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:P49281}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:P49281}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000269|PubMed:24448823}; Multi-pass membrane protein {ECO:0000255}. Extracellular vesicle membrane {ECO:0000250|UniProtKB:P49281}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P49281}.
uniprot
proteins
transmembrane_region
TRANSMEM 76..92; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 104..118; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 148..168; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 185..199; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 207..222; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 253..268; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 298..314; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 377..393; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 408..424; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 438..454; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 478..499; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P49281"; TRANSMEM 505..525; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P49279
uniprot
proteins