SLC12A4
entrez
6560
canonical
uniprot
Q9UP95
canonical
ensembl
ENSG00000124067
resolver
ensp
ENSP00000318557
resolver
ensp
ENSP00000438334
resolver
ensp
ENSP00000445962
resolver
ensp
ENSP00000528453
resolver
ensp
ENSP00000634441
resolver
genesymbol
SLC12A4
resolver
genesymbol_syn
KCC1
resolver
hgnc
HGNC:10913
resolver
uniprot
B4DF30
resolver
uniprot
B4DF69
resolver
uniprot
B4DR04
resolver
uniprot
B4DZ82
resolver
uniprot
B7ZAV0
resolver
uniprot
F5H066
resolver
uniprot
F5H0S9
resolver
uniprot
F5H3C0
resolver
uniprot
O60632
resolver
uniprot
O75893
resolver
uniprot
Q13953
resolver
uniprot
Q96LD5
resolver
uniprot_entry
B4DF30_HUMAN
resolver
uniprot_entry
S12A4_HUMAN
resolver
uniprot_sec
B4DF69
resolver
uniprot_sec
B4DR04
resolver
uniprot_sec
B4DZ82
resolver
uniprot_sec
B7ZAV0
resolver
uniprot_sec
F5H066
resolver
uniprot_sec
F5H0S9
resolver
uniprot_sec
F5H3C0
resolver
uniprot_sec
O60632
resolver
uniprot_sec
O75893
resolver
uniprot_sec
Q13953
resolver
uniprot_sec
Q96LD5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by WNK3. {ECO:0000269|PubMed:21613606}.
uniprot
proteins
amino_acid_sequence
MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
uniprot
proteins
function
FUNCTION: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). {ECO:0000250|UniProtKB:Q9JIS8, ECO:0000269|PubMed:10913127, ECO:0000269|PubMed:34031912, ECO:0000269|PubMed:35759661}.; FUNCTION: [Isoform 4]: No transporter activity. {ECO:0000269|PubMed:11551954}.
uniprot
proteins
mass_dalton
120650
uniprot
proteins
mutagenesis
MUTAGEN 135; /note="V->A: Decrease in Cl(-) efflux and reduced sensitivity to KCC inhibitor VU0463271."; /evidence="ECO:0000269|PubMed:35759661"; MUTAGEN 136; /note="I->A: Decrease in Cl(-) efflux."; /evidence="ECO:0000269|PubMed:35759661"; MUTAGEN 139; /note="L->A: Decrease in Cl(-) efflux."; /evidence="ECO:0000269|PubMed:35759661"; MUTAGEN 140; /note="R->Q: Decrease in Cl(-) efflux."; /evidence="ECO:0000269|PubMed:35759661"; MUTAGEN 215; /note="M->A: Decrease in Cl(-) efflux and reduced sensitivity to KCC inhibitor VU0463271."; /evidence="ECO:0000269|PubMed:35759661"; MUTAGEN 222; /note="E->A: Decrease in Cl(-) efflux and reduced sensitivity to KCC inhibitor VU0463271."; /evidence="ECO:0000269|PubMed:35759661"; MUTAGEN 223; /note="I->A: Decrease in Cl(-) efflux and reduced sensitivity to KCC inhibitor VU0463271."; /evidence="ECO:0000269|PubMed:35759661"; MUTAGEN 574; /note="L->A: Decrease in Cl(-) efflux."; /evidence="ECO:0000269|PubMed:35759661"; MUTAGEN 575; /note="D->A: Decrease in Cl(-) efflux."; /evidence="ECO:0000269|PubMed:35759661"; MUTAGEN 581; /note="L->A: Reduced sensitivity to KCC inhibitor VU0463271."; /evidence="ECO:0000269|PubMed:35759661
uniprot
proteins
post_translational_modification
PTM: Phosphorylated, phosphorylation may regulate transporter activity. {ECO:0000269|PubMed:34031912}.
uniprot
proteins
protein_family
K/Cl co-transporter subfamily
uniprot
proteins
protein_family
SLC12A transporter family
uniprot
proteins
pubmed
10564083
uniprot
proteins
pubmed
10913127
uniprot
proteins
pubmed
11551954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21613606
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
31649201
uniprot
proteins
pubmed
34031912
uniprot
proteins
pubmed
35759661
uniprot
proteins
pubmed
8663127
uniprot
proteins
pubmed
9516379
uniprot
proteins
sequence_length
1085
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:10913127}; Multi-pass membrane protein {ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912}.
uniprot
proteins
transmembrane_region
TRANSMEM 120..141; /note="Discontinuously helical; Name=1"; /evidence="ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR"; TRANSMEM 150..172; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR"; TRANSMEM 197..225; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR"; TRANSMEM 249..271; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR"; TRANSMEM 272..297; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR"; TRANSMEM 420..440; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR"; TRANSMEM 451..473; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR"; TRANSMEM 505..531; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR"; TRANSMEM 555..575; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR"; TRANSMEM 576..598; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR"; TRANSMEM 613..635; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR"; TRANSMEM 636..651; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR
uniprot
proteins