CD163
entrez
9332
canonical
uniprot
Q86VB7
canonical
ensembl
ENSG00000177575
resolver
ensp
ENSP00000352071
resolver
ensp
ENSP00000379863
resolver
ensp
ENSP00000403885
resolver
ensp
ENSP00000564076
resolver
ensp
ENSP00000630421
resolver
enst
ENST00000396620
resolver
genesymbol
CD163
resolver
genesymbol_syn
M130
resolver
hgnc
HGNC:1631
resolver
uniprot
C9JHR8
resolver
uniprot
C9JIG2
resolver
uniprot
Q07898
resolver
uniprot
Q07899
resolver
uniprot
Q07900
resolver
uniprot
Q07901
resolver
uniprot
Q2VLH7
resolver
uniprot_entry
C163A_HUMAN
resolver
uniprot_entry
C9JHR8_HUMAN
resolver
uniprot_sec
C9JIG2
resolver
uniprot_sec
Q07898
resolver
uniprot_sec
Q07899
resolver
uniprot_sec
Q07900
resolver
uniprot_sec
Q07901
resolver
uniprot_sec
Q2VLH7
resolver
amino_acid_sequence
MSKLRMVLLEDSGSADFRRHFVNLSPFTITVVLLLSACFVTSSLGGTDKELRLVDGENKCSGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPGWANSSAGSGRIWMDHVSCRGNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMRLTRGGNMCSGRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNCKHQGWGKHNCDHAEDAGVICSKGADLSLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTAIGRVNASKGFGHIWLDSVSCQGHEPAIWQCKHHEWGKHYCNHNEDAGVTCSDGSDLELRLRGGGSRCAGTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGSALKTSYQVYSKIQATNTWLFLSSCNGNETSLWDCKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDIPCSGRVEVKHGDTWGSICDSDFSLEAASVLCRELQCGTVVSILGGAHFGEGNGQIWAEEFQCEGHESHLSLCPVAPRPEGTCSHSRDVGVVCSRYTEIRLVNGKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQIWRHMFHCTGTEQHMGDCPVTALGASLCPSEQVASVICSGNQSQTLSSCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGRCAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQCHSHGWGQQNCRHKEDAGVICSEFMSLRLTSEASREACAGRLEVFYNGAWGTVGKSSMSETTVGVVCRQLGCADKGKINPASLDKAMSIPMWVDNVQCPKGPDTLWQCPSSPWEKRLASPSEETWITCDNKIRLQEGPTSCSGRVEIWHGGSWGTVCDDSWDLDDAQVVCQQLGCGPALKAFKEAEFGQGTGPIWLNEVKCKGNESSLWDCPARRWGHSECGHKEDAAVNCTDISVQKTPQKATTGRSSRQSSFIAVGILGVVLLAIFVALFFLTKKRRQRQRLAVSSRGENLVHQIQYREMNSCLNADDLDLMNSSENSHESADFSAAELISVSKFLPISGMEKEAILSHTEKENGNL
uniprot
proteins
function
FUNCTION: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.; FUNCTION: After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
uniprot
proteins
mass_dalton
125451
uniprot
proteins
mutagenesis
MUTAGEN 1072; /note="T->A: Impaired phosphorylation by PRKCA."; /evidence="ECO:0000269|PubMed:11298324"; MUTAGEN 1084; /note="S->A: Impaired phosphorylation by PRKCA."; /evidence="ECO:0000269|PubMed:11298324"; MUTAGEN 1096; /note="Y->A: Massive decrease of endocytotic activity."; /evidence="ECO:0000269|PubMed:16434690
uniprot
proteins
post_translational_modification
PTM: A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs. {ECO:0000269|PubMed:10066432, ECO:0000269|PubMed:12296867, ECO:0000269|PubMed:15075364, ECO:0000269|PubMed:15448162}.; PTM: Phosphorylated. {ECO:0000305|PubMed:11298324}.
uniprot
proteins
pubmed
10066432
uniprot
proteins
pubmed
10403791
uniprot
proteins
pubmed
10577520
uniprot
proteins
pubmed
10648003
uniprot
proteins
pubmed
11196644
uniprot
proteins
pubmed
11298324
uniprot
proteins
pubmed
12208511
uniprot
proteins
pubmed
12296867
uniprot
proteins
pubmed
12377940
uniprot
proteins
pubmed
15075364
uniprot
proteins
pubmed
15448162
uniprot
proteins
pubmed
15478309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16434690
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8370408
uniprot
proteins
sequence_length
1156
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Soluble CD163]: Secreted {ECO:0000269|PubMed:12296867}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10577520, ECO:0000269|PubMed:10648003}; Single-pass type I membrane protein {ECO:0000269|PubMed:10577520, ECO:0000269|PubMed:10648003}. Note=Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.
uniprot
proteins
transmembrane_region
TRANSMEM 1051..1071; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins