PM20D1
entrez
148811
canonical
uniprot
Q6GTS8
canonical
ensembl
ENSG00000162877
resolver
ensp
ENSP00000356104
resolver
genesymbol
PM20D1
resolver
hgnc
HGNC:26518
resolver
uniprot
Q6P4E3
resolver
uniprot
Q96DM4
resolver
uniprot_entry
P20D1_HUMAN
resolver
uniprot_sec
Q6P4E3
resolver
uniprot_sec
Q96DM4
resolver
activity_regulation
ACTIVITY REGULATION: Lipoproteins are powerful coactivators of PM20D1 activity in vitro and NAA biosynthesis in vivo. {ECO:0000250|UniProtKB:Q8C165}.
uniprot
proteins
amino_acid_sequence
MAQRCVCVLALVAMLLLVFPTVSRSMGPRSGEHQRASRIPSQFSKEERVAMKEALKGAIQIPTVTFSSEKSNTTALAEFGKYIHKVFPTVVSTSFIQHEVVEEYSHLFTIQGSDPSLQPYLLMAHFDVVPAPEEGWEVPPFSGLERDGIIYGRGTLDDKNSVMALLQALELLLIRKYIPRRSFFISLGHDEESSGTGAQRISALLQSRGVQLAFIVDEGGFILDDFIPNFKKPIALIAVSEKGSMNLMLQVNMTSGHSSAPPKETSIGILAAAVSRLEQTPMPIIFGSGTVVTVLQQLANEFPFPVNIILSNPWLFEPLISRFMERNPLTNAIIRTTTALTIFKAGVKFNVIPPVAQATVNFRIHPGQTVQEVLELTKNIVADNRVQFHVLSAFDPLPVSPSDDKALGYQLLRQTVQSVFPEVNITAPVTSIGNTDSRFFTNLTTGIYRFYPIYIQPEDFKRIHGVNEKISVQAYETQVKFIFELIQNADTDQEPVSHLHKL
uniprot
proteins
ec_number
3.5.1.114
uniprot
proteins
ec_number
3.5.1.14
uniprot
proteins
function
FUNCTION: Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase (PubMed:27374330). It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction (PubMed:27374330). Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles (By similarity). {ECO:0000250|UniProtKB:Q8C165, ECO:0000269|PubMed:27374330}.
uniprot
proteins
mass_dalton
55741
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid metabolism. {ECO:0000269|PubMed:27374330}.; PATHWAY: Energy metabolism. {ECO:0000269|PubMed:27374330}.; PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000269|PubMed:27374330}.
uniprot
proteins
protein_family
Peptidase M20A family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
27374330
uniprot
proteins
pubmed
29736028
uniprot
proteins
sequence_length
502
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8C165}.
uniprot
proteins