PPM1B
entrez
5495
canonical
uniprot
O75688
canonical
ensembl
ENSG00000138032
resolver
ensp
ENSP00000282412
resolver
ensp
ENSP00000326089
resolver
ensp
ENSP00000367813
resolver
ensp
ENSP00000387287
resolver
genesymbol
PPM1B
resolver
genesymbol_syn
PP2CB
resolver
hgnc
HGNC:9276
resolver
uniprot
Q461Q2
resolver
uniprot
Q4J6C1
resolver
uniprot
Q4J6C2
resolver
uniprot
Q658R4
resolver
uniprot
Q96ER6
resolver
uniprot
Q9HAY8
resolver
uniprot_entry
PPM1B_HUMAN
resolver
uniprot_sec
Q461Q2
resolver
uniprot_sec
Q4J6C1
resolver
uniprot_sec
Q4J6C2
resolver
uniprot_sec
Q658R4
resolver
uniprot_sec
Q96ER6
resolver
uniprot_sec
Q9HAY8
resolver
amino_acid_sequence
MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRNVIEAVYSRLNPHRESDGASDEAEESGSQGKLVEALRQMRINHRGNYRQLLEEMLTSYRLAKVEGEESPAEPAATATSSNSDAGNPVTMQESHTESESGLAELDSSNEDAGTKMSGEKI
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}.
uniprot
proteins
mass_dalton
52643
uniprot
proteins
post_translational_modification
PTM: Isgylation negatively regulates its activity. {ECO:0000269|PubMed:16872604}.; PTM: N-myristoylation is essential for the recognition of its substrates for dephosphorylation. {ECO:0000250}.
uniprot
proteins
protein_family
PP2C family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
10934208
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15913950
uniprot
proteins
pubmed
16872604
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18058037
uniprot
proteins
pubmed
18642328
uniprot
proteins
pubmed
18930133
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22750291
uniprot
proteins
pubmed
22781750
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
9684878
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22781750}. Membrane {ECO:0000250|UniProtKB:P36993}; Lipid-anchor {ECO:0000250|UniProtKB:P36993}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250|UniProtKB:P36993}.
uniprot
proteins