STEAP1
entrez
26872
canonical
uniprot
Q9UHE8
canonical
ensembl
ENSG00000164647
resolver
ensp
ENSP00000297205
resolver
ensp
ENSP00000562368
resolver
ensp
ENSP00000597805
resolver
ensp
ENSP00000625288
resolver
enst
ENST00000297205
resolver
enst
ENST00000892309
resolver
enst
ENST00000927746
resolver
enst
ENST00000955229
resolver
genesymbol
STEAP1
resolver
genesymbol_syn
PRSS24
resolver
genesymbol_syn
STEAP
resolver
hgnc
HGNC:11378
resolver
uniprot
A4D1E0
resolver
uniprot
O95034
resolver
uniprot_entry
STEA1_HUMAN
resolver
uniprot_sec
A4D1E0
resolver
uniprot_sec
O95034
resolver
amino_acid_sequence
MESRKDITNQEELWKMKPRRNLEEDDYLHKDTGETSMLKRPVLLHLHQTAHADEFDCPSELQHTQELFPQWHLPIKIAAIIASLTFLYTLLREVIHPLATSHQQYFYKIPILVINKVLPMVSITLLALVYLPGVIAAIVQLHNGTKYKKFPHWLDKWMLTRKQFGLLSFFFAVLHAIYSLSYPMRRSYRYKLLNWAYQQVQQNKEDAWIEHDVWRMEIYVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTIHALIFAWNKWIDIKQFVWYTPPTFMIAVFLPIVVLIFKSILFLPCLRKKILKIRHGWEDVTKINKTEICSQL
uniprot
proteins
function
FUNCTION: Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH. Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4. {ECO:0000269|PubMed:32409586}.
uniprot
proteins
mass_dalton
39851
uniprot
proteins
protein_family
STEAP family
uniprot
proteins
pubmed
10588738
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16609065
uniprot
proteins
pubmed
32409586
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q9CWR7}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:32409586}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 119..139; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 164..184; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 218..238; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 291..311; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins