CTSZ
entrez
1522
canonical
uniprot
Q9UBR2
canonical
ensembl
ENSG00000101160
resolver
ensp
ENSP00000217131
resolver
enst
ENST00000217131
resolver
genesymbol
CTSZ
resolver
hgnc
HGNC:2547
resolver
uniprot
B2RC40
resolver
uniprot
O75331
resolver
uniprot
Q9UQV5
resolver
uniprot
Q9UQV6
resolver
uniprot_entry
CATZ_HUMAN
resolver
uniprot_sec
B2RC40
resolver
uniprot_sec
O75331
resolver
uniprot_sec
Q9UQV5
resolver
uniprot_sec
Q9UQV6
resolver
activity_regulation
ACTIVITY REGULATION: The disulfide bridge formed between Cys-33 in the propeptide and the active site residue Cys-92 may prevent activation of the zymogen through formation of a reversible covalent bond with the active site residue. {ECO:0000305|PubMed:10656802}.
uniprot
proteins
amino_acid_sequence
MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGDPIV
uniprot
proteins
ec_number
3.4.18.1
uniprot
proteins
function
FUNCTION: Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234). Capable of producing kinin potentiating peptides (By similarity). {ECO:0000250|UniProtKB:Q9R1T3, ECO:0000269|PubMed:10504234}.
uniprot
proteins
mass_dalton
33868
uniprot
proteins
protein_family
Peptidase C1 family
uniprot
proteins
pubmed
10504234
uniprot
proteins
pubmed
10653162
uniprot
proteins
pubmed
10653163
uniprot
proteins
pubmed
10656802
uniprot
proteins
pubmed
10745011
uniprot
proteins
pubmed
10760573
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9642240
uniprot
proteins
pubmed
9738465
uniprot
proteins
sequence_length
303
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome.
uniprot
proteins