Gnl3
entrez
30877
canonical
uniprot
Q8CI11
canonical
ensembl
ENSMUSG00000042354
resolver
ensp
ENSMUSP00000047119
resolver
genesymbol
Gnl3
resolver
genesymbol_syn
Ns
resolver
uniprot
Q811R9
resolver
uniprot
Q811S8
resolver
uniprot
Q8BK21
resolver
uniprot_entry
GNL3_MOUSE
resolver
uniprot_sec
Q811R9
resolver
uniprot_sec
Q811S8
resolver
uniprot_sec
Q8BK21
resolver
amino_acid_sequence
MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKRGHKKPRKDPGVPNSAPFKEALLREAELRKQQLEELKQQQKLDRQKEQERKRKLEVSPGDEQSNVETREESDEPKRKKAKAGKQNPKKLHCQELKKVIEASDIVLEVLDARDPLGCRCPQIEEAVIQSGSKKLILVLNKSDLVPKENLENWLNYLNKELPTVVFKASTNLKNRKTFKIKKKKVVPFQSKICCGKEALWKLLGDFQQSCGKDIQVGVIGFPNVGKSSVINSLKQEWICNVGISMGLTRSMQIVPLDKQITIIDSPCLIISPCNSPTALALRSPASIEELRPLEAASAILSQADNEQVVLKYTVPEYKDSLHFFTKLAQRRGLHQKGGSPNVESAAKLVWSEWTGASLGYYCHPPASWNHSLHFNENIAAVMKKGFNLEELEKNNAHSIQVLKGPHLTNRILFRSSGLTNGILDEKDIVEESPRQTEDKQDADDQENGSGERNAEISDVAPVEETRELSPEQSTAGKPSDGSSALDRASQEDETYDFTTDYI
uniprot
proteins
function
FUNCTION: May be required to maintain the proliferative capacity of stem cells (By similarity). Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation. {ECO:0000250, ECO:0000269|PubMed:21132010}.
uniprot
proteins
mass_dalton
60786
uniprot
proteins
mutagenesis
MUTAGEN 256; /note="G->V: Mislocalized to the nucleoplasm. No effect on MDM2-binding."; /evidence="ECO:0000269|PubMed:21132010
uniprot
proteins
protein_family
TRAFAC class YlqF/YawG GTPase family
uniprot
proteins
pubmed
12464630
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21132010
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21132010}. Nucleus, nucleolus {ECO:0000269|PubMed:12464630}. Note=Shuttles between the nucleus and nucleolus. {ECO:0000250|UniProtKB:Q811S9}.
uniprot
proteins