Pdia6
entrez
71853
canonical
uniprot
Q922R8
canonical
ensembl
ENSMUSG00000020571
resolver
ensp
ENSMUSP00000052912
resolver
ensp
ENSMUSP00000159304
resolver
enst
ENSMUST00000057288
resolver
enst
ENSMUST00000239402
resolver
genesymbol
Pdia6
resolver
genesymbol_syn
Txndc7
resolver
uniprot
A0ACM8Q8K0
resolver
uniprot
F7DBQ0
resolver
uniprot
Q3TML0
resolver
uniprot
Q8BK54
resolver
uniprot_entry
A0ACM8Q8K0_MOUSE
resolver
uniprot_entry
PDIA6_MOUSE
resolver
uniprot_entry
Q3TML0_MOUSE
resolver
uniprot_sec
F7DBQ0
resolver
uniprot_sec
Q8BK54
resolver
amino_acid_sequence
MARLVLGLVSCTFFLAVSGLYSSSDDVIELTPSNFNREVIQSDGLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVNADKHQSLGGQYGVQGFPTIKIFGANKNKPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRGDSSSKKDVVELTDDTFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVKLAAVDATVNQVLASRYGIKGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKKTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQYELENALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGSFPTITPREPWDGKDGELPVEDDIDLSDVELDDLEKDEL
uniprot
proteins
ec_number
5.3.4.1
uniprot
proteins
function
FUNCTION: May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:24508390). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (By similarity). May also regulate the UPR via the EIF2AK3 UPR sensor (By similarity). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (By similarity). {ECO:0000250|UniProtKB:Q15084, ECO:0000269|PubMed:24508390}.
uniprot
proteins
mass_dalton
48100
uniprot
proteins
protein_family
Protein disulfide isomerase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24508390
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q15084}. Cell membrane {ECO:0000250|UniProtKB:Q15084}. Melanosome {ECO:0000250|UniProtKB:Q15084}.
uniprot
proteins