Kcne2
entrez
171138
canonical
uniprot
P63161
canonical
ensembl
ENSRNOG00000029811
resolver
ensembl
ENSRNOG00055017442
resolver
ensembl
ENSRNOG00060018583
resolver
ensembl
ENSRNOG00065013379
resolver
ensp
ENSRNOP00000045279
resolver
ensp
ENSRNOP00000078157
resolver
ensp
ENSRNOP00000080461
resolver
ensp
ENSRNOP00000081079
resolver
ensp
ENSRNOP00000103279
resolver
ensp
ENSRNOP00000107594
resolver
ensp
ENSRNOP00000108015
resolver
ensp
ENSRNOP00055023703
resolver
ensp
ENSRNOP00055023705
resolver
ensp
ENSRNOP00055023706
resolver
ensp
ENSRNOP00060025949
resolver
ensp
ENSRNOP00060025958
resolver
ensp
ENSRNOP00060025987
resolver
ensp
ENSRNOP00065017052
resolver
ensp
ENSRNOP00065017055
resolver
ensp
ENSRNOP00065017059
resolver
enst
ENSRNOT00000040844
resolver
enst
ENSRNOT00000093948
resolver
enst
ENSRNOT00000094999
resolver
enst
ENSRNOT00000099713
resolver
enst
ENSRNOT00000142903
resolver
enst
ENSRNOT00000145526
resolver
enst
ENSRNOT00000149391
resolver
enst
ENSRNOT00055029513
resolver
enst
ENSRNOT00055029515
resolver
enst
ENSRNOT00055029516
resolver
enst
ENSRNOT00060031926
resolver
enst
ENSRNOT00060031935
resolver
enst
ENSRNOT00060031964
resolver
enst
ENSRNOT00065021999
resolver
enst
ENSRNOT00065022005
resolver
enst
ENSRNOT00065022008
resolver
genesymbol
Kcne2
resolver
uniprot
Q5FVT9
resolver
uniprot
Q9WTW0
resolver
uniprot_entry
KCNE2_RAT
resolver
uniprot_sec
Q5FVT9
resolver
uniprot_sec
Q9WTW0
resolver
amino_acid_sequence
MTTLANLTQTLEDAFKKVFITYMDSWRRNTTAEQQALQARVDAENFYYVILYLMVMIGMFAFIVVAILVSTVKSKRREHSQDPYHQYIVEDWQQKYRSQILHLEDSKATIHENLGATGFTVSP
uniprot
proteins
function
FUNCTION: Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE2 beta subunit modulates the gating kinetics and enhances stability of the channel complex (PubMed:11420311, PubMed:19219384). Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:19219384). Associates with KCNH2/HERG alpha subunit Kv channel to form the rapidly activating component of the delayed rectifying potassium current (IKr) in heart (By similarity). May associate with KCNQ2 and/or KCNQ3 alpha subunits to modulate the native M-type current (By similarity). May associate with HCN1 and HCN2 channel subunits to increase potassium current (PubMed:11420311). Forms a heterooligomer complex with KCNQ1/KVLQT1 alpha subunits which leads to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity). {ECO:0000250|UniProtKB:Q9D808, ECO:0000250|UniProtKB:Q9Y6J6, ECO:0000269|PubMed:11420311, ECO:0000269|PubMed:19219384}.
uniprot
proteins
mass_dalton
14356
uniprot
proteins
protein_family
Potassium channel KCNE family
uniprot
proteins
pubmed
10219239
uniprot
proteins
pubmed
11420311
uniprot
proteins
pubmed
14679187
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19219384
uniprot
proteins
sequence_length
123
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14679187, ECO:0000269|PubMed:19219384}; Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:Q9D808}; Single-pass membrane protein {ECO:0000255}. Note=Colocalizes with KCNB1 at the plasma membrane. {ECO:0000269|PubMed:19219384}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins