Sox2
entrez
20674
canonical
uniprot
P48432
canonical
ensembl
ENSMUSG00000074637
resolver
ensp
ENSMUSP00000096755
resolver
enst
ENSMUST00000099151
resolver
genesymbol
Sox2
resolver
genesymbol_syn
Sox-2
resolver
uniprot
F6PWX2
resolver
uniprot
Q60I23
resolver
uniprot_entry
F6PWX2_MOUSE
resolver
uniprot_entry
Q60I23_MOUSE
resolver
uniprot_entry
SOX2_MOUSE
resolver
amino_acid_sequence
MYNMMETELKPPGPQQASGGGGGGGNATAAATGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGGGLNQRMDSYAHMNGWSNGSYSMMQEQLGYPQHPGLNAHGAAQMQPMHRYVVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMAQHYQSGPVPGTAKYGTLPLSHM
uniprot
proteins
function
FUNCTION: Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (PubMed:15863505, PubMed:17097055, PubMed:19740739, PubMed:32703285). Binds to the proximal enhancer region of NANOG (PubMed:15863505). Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (PubMed:22198669). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity). {ECO:0000250|UniProtKB:P48430, ECO:0000250|UniProtKB:P48431, ECO:0000269|PubMed:15863505, ECO:0000269|PubMed:17097055, ECO:0000269|PubMed:19740739, ECO:0000269|PubMed:22198669}.
uniprot
proteins
mass_dalton
34454
uniprot
proteins
mutagenesis
MUTAGEN 247; /note="K->R: Absence of sumoylation. Increased FGF4 activation. No effect on nuclear localization."; /evidence="ECO:0000269|PubMed:17097055
uniprot
proteins
post_translational_modification
PTM: Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation. {ECO:0000269|PubMed:17097055}.; PTM: Methylation at Lys-44 and Lys-119 is necessary for the regulation of SOX2 proteasomal degradation. {ECO:0000250|UniProtKB:P48431}.; PTM: Ubiquitinated by WWP2, leading to proteasomal degradation. {ECO:0000250|UniProtKB:P48431}.
uniprot
proteins
pubmed
15863505
uniprot
proteins
pubmed
16904174
uniprot
proteins
pubmed
17097055
uniprot
proteins
pubmed
17728342
uniprot
proteins
pubmed
19349578
uniprot
proteins
pubmed
19740739
uniprot
proteins
pubmed
22198669
uniprot
proteins
pubmed
29358331
uniprot
proteins
pubmed
30442713
uniprot
proteins
pubmed
32127020
uniprot
proteins
pubmed
32703285
uniprot
proteins
pubmed
32758484
uniprot
proteins
pubmed
7590241
uniprot
proteins
pubmed
8625802
uniprot
proteins
sequence_length
319
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:17097055, ECO:0000269|PubMed:19349578, ECO:0000269|PubMed:32127020}. Cytoplasm {ECO:0000269|PubMed:19349578}. Note=Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor. {ECO:0000269|PubMed:19349578}.
uniprot
proteins