CD7
entrez
924
canonical
uniprot
P09564
canonical
ensembl
ENSG00000173762
resolver
ensp
ENSP00000312027
resolver
enst
ENST00000312648
resolver
genesymbol
CD7
resolver
hgnc
HGNC:1695
resolver
uniprot
Q29VG3
resolver
uniprot_entry
CD7_HUMAN
resolver
uniprot_entry
Q29VG3_HUMAN
resolver
amino_acid_sequence
MAGPPRLLLLPLLLALARGLPGALAAQEVQQSPHCTTVPVGASVNITCSTSGGLRGIYLRQLGPQPQDIIYYEDGVVPTTDRRFRGRIDFSGSQDNLTITMHRLQLSDTGTYTCQAITEVNVYGSGTLVLVTEEQSQGWHRCSDAPPRASALPAPPTGSALPDPQTASALPDPPAASALPAALAVISFLLGLGLGVACVLARTQIKKLCSWRDKNSAACVVYEDMSHSRCNTLSSPNQYQ
uniprot
proteins
function
FUNCTION: Transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors (PubMed:7506726). Plays a costimulatory role in T-cell activation upon binding to its ligand K12/SECTM1 (PubMed:10652336). In turn, mediates the production of cytokines such as IL-2 (PubMed:1709867). On resting NK-cells, CD7 activation results in a significant induction of interferon-gamma levels (PubMed:7506726). {ECO:0000269|PubMed:10652336, ECO:0000269|PubMed:1709867, ECO:0000269|PubMed:7506726}.
uniprot
proteins
mass_dalton
25409
uniprot
proteins
pubmed
10652336
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1703303
uniprot
proteins
pubmed
1709867
uniprot
proteins
pubmed
1711009
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
2479685
uniprot
proteins
pubmed
3501369
uniprot
proteins
pubmed
7506726
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 181..201; /note="Helical"; /evidence="ECO:0000305
uniprot
proteins