Kcnip3
entrez
65199
canonical
uniprot
Q9JM47
canonical
ensembl
ENSRNOG00000014152
resolver
ensp
ENSRNOP00000047927
resolver
ensp
ENSRNOP00000052766
resolver
ensp
ENSRNOP00000071572
resolver
ensp
ENSRNOP00000073871
resolver
enst
ENSRNOT00000055915
resolver
enst
ENSRNOT00000090765
resolver
genesymbol
Kcnip3
resolver
genesymbol_syn
Csen
resolver
genesymbol_syn
Dream
resolver
genesymbol_syn
Kchip3
resolver
uniprot
A0A0G2K6M5
resolver
uniprot
A0A8L2QQE1
resolver
uniprot_entry
A0A0G2K6M5_RAT
resolver
uniprot_entry
A0A8L2QQE1_RAT
resolver
uniprot_entry
CSEN_RAT
resolver
amino_acid_sequence
MQRTKEAMKASDGSLLGDPGRIPLSKREGIKWQRPRFTRQALMRCCLIKWILSSAAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYSQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPLEHVERFFQKMDRNQDGVVTIDEFLETCQKDENIMSSMQLFENVI
uniprot
proteins
function
FUNCTION: Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). {ECO:0000250|UniProtKB:Q9QXT8}.; FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (By similarity). {ECO:0000250|UniProtKB:Q9Y2W7}.; FUNCTION: May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation (By similarity). {ECO:0000250|UniProtKB:Q9Y2W7}.
uniprot
proteins
mass_dalton
29471
uniprot
proteins
mutagenesis
MUTAGEN 45..46; /note="CC->AA,SS: Greatly reduces plasma membrane localization."; /evidence="ECO:0000269|PubMed:12006572
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Palmitoylation enhances association with the plasma membrane. {ECO:0000269|PubMed:12006572}.; PTM: Proteolytically cleaved by caspase-3. {ECO:0000250}.
uniprot
proteins
protein_family
Recoverin family
uniprot
proteins
pubmed
10676964
uniprot
proteins
pubmed
12006572
uniprot
proteins
pubmed
15356203
uniprot
proteins
pubmed
15485870
uniprot
proteins
pubmed
16123112
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
256
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12006572}. Cell membrane {ECO:0000269|PubMed:12006572, ECO:0000269|PubMed:16123112}; Lipid-anchor {ECO:0000269|PubMed:12006572}. Endoplasmic reticulum {ECO:0000269|PubMed:12006572}. Golgi apparatus {ECO:0000269|PubMed:12006572}. Nucleus {ECO:0000250|UniProtKB:Q9Y2W7}. Note=Also membrane-bound, associated with the plasma membrane. In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. {ECO:0000250|UniProtKB:Q9Y2W7}.
uniprot
proteins