Elavl1
entrez
363854
canonical
uniprot
B5DF91
canonical
ensembl
ENSRNOG00000001069
resolver
ensembl
ENSRNOG00055004143
resolver
ensembl
ENSRNOG00060002516
resolver
ensembl
ENSRNOG00065005840
resolver
ensp
ENSRNOP00000001415
resolver
ensp
ENSRNOP00055005075
resolver
ensp
ENSRNOP00060002868
resolver
ensp
ENSRNOP00065006198
resolver
enst
ENSRNOT00000001415
resolver
enst
ENSRNOT00055006628
resolver
enst
ENSRNOT00060004044
resolver
enst
ENSRNOT00065008750
resolver
genesymbol
Elavl1
resolver
genesymbol_syn
Hur
resolver
uniprot_entry
ELAV1_RAT
resolver
amino_acid_sequence
MSNGYEDHMAEDCRDDIGRTNLIVNYLPQNMTQEELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAISTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNMALLSQLYHSPARRFGGPVHHQAQRFRFSPMGVDHMSGISGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK
uniprot
proteins
function
FUNCTION: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (By similarity). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (By similarity). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (By similarity). {ECO:0000250|UniProtKB:P70372, ECO:0000250|UniProtKB:Q15717}.
uniprot
proteins
mass_dalton
36169
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPKAPK2. Phosphorylated by PRKCD. {ECO:0000250|UniProtKB:Q15717}.; PTM: Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge. {ECO:0000250|UniProtKB:Q15717}.
uniprot
proteins
protein_family
RRM elav family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18161049
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18161049}. Nucleus {ECO:0000250|UniProtKB:Q15717}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P70372}. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q15717}. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2. Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes. Localizes to the stress granules in the presence of PLEKHN1. {ECO:0000250|UniProtKB:Q15717}.
uniprot
proteins