CSNK1A1
entrez
1452
canonical
uniprot
P48729
canonical
ensembl
ENSG00000113712
resolver
ensp
ENSP00000261798
resolver
ensp
ENSP00000367074
resolver
ensp
ENSP00000427031
resolver
ensp
ENSP00000499757
resolver
genesymbol
CSNK1A1
resolver
hgnc
HGNC:2451
resolver
uniprot
B4DER9
resolver
uniprot
D3DQG0
resolver
uniprot
D3DQG1
resolver
uniprot
Q4JJA0
resolver
uniprot
Q5U046
resolver
uniprot
Q5U047
resolver
uniprot
Q6FGA2
resolver
uniprot
Q6PJ06
resolver
uniprot
Q71TU5
resolver
uniprot
Q96HD2
resolver
uniprot
Q9UDK3
resolver
uniprot_entry
B4DER9_HUMAN
resolver
uniprot_entry
KC1A_HUMAN
resolver
uniprot_entry
Q6PJ06_HUMAN
resolver
uniprot_sec
D3DQG0
resolver
uniprot_sec
D3DQG1
resolver
uniprot_sec
Q4JJA0
resolver
uniprot_sec
Q5U046
resolver
uniprot_sec
Q5U047
resolver
uniprot_sec
Q6FGA2
resolver
uniprot_sec
Q71TU5
resolver
uniprot_sec
Q96HD2
resolver
uniprot_sec
Q9UDK3
resolver
amino_acid_sequence
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Phosphorylates a large number of proteins (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). {ECO:0000250|UniProtKB:Q8BK63, ECO:0000269|PubMed:11955436, ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:18305108, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:23902688}.
uniprot
proteins
mass_dalton
38915
uniprot
proteins
mutagenesis
MUTAGEN 141; /note="N->A: Catalytically inactive. No effect on interaction with SACK1 family members."; /evidence="ECO:0000269|PubMed:29789297
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MTOR in response to mitogenic stimulation, leading to its activation (PubMed:22017877). Recognized by CRBN and is targeted for degradation by DCX (DDB1-CUL4-X-box) E3 protein ligase complex (PubMed:41565821). {ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:41565821}.
uniprot
proteins
protein_family
CK1 Ser/Thr protein kinase family
uniprot
proteins
protein_family
Casein kinase I subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11955436
uniprot
proteins
pubmed
1409656
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18305108
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22017875
uniprot
proteins
pubmed
22017877
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23902688
uniprot
proteins
pubmed
29789297
uniprot
proteins
pubmed
31338967
uniprot
proteins
pubmed
41565821
uniprot
proteins
pubmed
7797465
uniprot
proteins
pubmed
8050587
uniprot
proteins
sequence_length
337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1409656}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:1409656}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:1409656}. Nucleus speckle {ECO:0000303|PubMed:18305108}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8BK63}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8BK63}. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688). {ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:23902688}.
uniprot
proteins