NEU4
entrez
129807
canonical
uniprot
Q8WWR8
canonical
ensembl
ENSG00000204099
resolver
ensembl
ENSG00000277926
resolver
ensp
ENSP00000320318
resolver
ensp
ENSP00000375830
resolver
ensp
ENSP00000384804
resolver
ensp
ENSP00000385149
resolver
ensp
ENSP00000385402
resolver
genesymbol
NEU4
resolver
hgnc
HGNC:21328
resolver
uniprot
A8K056
resolver
uniprot
B3KR54
resolver
uniprot
J3KNJ5
resolver
uniprot
Q3KR05
resolver
uniprot
Q96D64
resolver
uniprot_entry
B3KR54_HUMAN
resolver
uniprot_entry
NEUR4_HUMAN
resolver
uniprot_entry
Q3KR05_HUMAN
resolver
uniprot_sec
A8K056
resolver
uniprot_sec
J3KNJ5
resolver
uniprot_sec
Q96D64
resolver
amino_acid_sequence
MGVPRTPSRTVLFERERTGLTYRVPSLLPVPPGPTLLAFVEQRLSPDDSHAHRLVLRRGTLAGGSVRWGALHVLGTAALAEHRSMNPCPVHDAGTGTVFLFFIAVLGHTPEAVQIATGRNAARLCCVASRDAGLSWGSARDLTEEAIGGAVQDWATFAVGPGHGVQLPSGRLLVPAYTYRVDRRECFGKICRTSPHSFAFYSDDHGRTWRCGGLVPNLRSGECQLAAVDGGQAGSFLYCNARSPLGSRVQALSTDEGTSFLPAERVASLPETAWGCQGSIVGFPAPAPNRPRDDSWSVGPGSPLQPPLLGPGVHEPPEEAAVDPRGGQVPGGPFSRLQPRGDGPRQPGPRPGVSGDVGSWTLALPMPFAAPPQSPTWLLYSHPVGRRARLHMGIRLSQSPLDPRSWTEPWVIYEGPSGYSDLASIGPAPEGGLVFACLYESGARTSYDEISFCTFSLREVLENVPASPKPPNLGDKPRGCCWPS
uniprot
proteins
ec_number
3.2.1.18
uniprot
proteins
function
FUNCTION: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:15213228, PubMed:15847605, PubMed:21521691). Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (PubMed:21521691). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:15847605). {ECO:0000250|UniProtKB:Q8BZL1, ECO:0000269|PubMed:15213228, ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:21521691}.
uniprot
proteins
mass_dalton
51572
uniprot
proteins
mutagenesis
MUTAGEN 5; /note="R->A: Impairs mitochondrial targeting."; /evidence="ECO:0000269|PubMed:15847605
uniprot
proteins
post_translational_modification
PTM: [Isoform 2]: N-glycosylated. {ECO:0000269|PubMed:15213228}.
uniprot
proteins
protein_family
Glycosyl hydrolase 33 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14962670
uniprot
proteins
pubmed
15213228
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15847605
uniprot
proteins
pubmed
15885103
uniprot
proteins
pubmed
19797320
uniprot
proteins
pubmed
21521691
uniprot
proteins
sequence_length
484
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:21521691}; Peripheral membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15847605}; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:15847605}; Peripheral membrane protein. Mitochondrion membrane {ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:19797320}; Peripheral membrane protein. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q8BZL1}. Note=Predominantly associates with endoplasmic reticulum membranes. Only a small fraction associates with mitochondrial and plasma membranes. {ECO:0000269|PubMed:19797320, ECO:0000269|PubMed:21521691}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion inner membrane {ECO:0000269|PubMed:15847605}; Peripheral membrane protein. Mitochondrion outer membrane {ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:19797320}; Peripheral membrane protein. Lysosome lumen {ECO:0000269|PubMed:15213228}. Note=According to PubMed:15213228, isoform 2 is soluble, N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N-glycosylation site is predicted from the sequence.
uniprot
proteins