Ttc21b
entrez
73668
canonical
uniprot
Q0HA38
canonical
ensembl
ENSMUSG00000034848
resolver
ensp
ENSMUSP00000099779
resolver
ensp
ENSMUSP00000131758
resolver
ensp
ENSMUSP00000302684
resolver
ensp
ENSMUSP00000302685
resolver
enst
ENSMUST00000102718
resolver
enst
ENSMUST00000125446
resolver
genesymbol
Ttc21b
resolver
genesymbol_syn
Ift139
resolver
genesymbol_syn
Kiaa1992
resolver
genesymbol_syn
Thm1
resolver
uniprot
E9PVK4
resolver
uniprot
Q3V1U7
resolver
uniprot
Q69Z46
resolver
uniprot_entry
E9PVK4_MOUSE
resolver
uniprot_entry
TT21B_MOUSE
resolver
uniprot_sec
Q3V1U7
resolver
uniprot_sec
Q69Z46
resolver
amino_acid_sequence
MDSQGLKTLINYYCQERYYHHVLLVASEGMKKYSSDPVFRFYHAYGTLMEGKAQEALREFEAIKNKQDVSLCSLMALMYVHKMSPNPDREAILELDTKMKEQRKEAGRKALYHAGLFLWHIGRHDKAREYIDRMSKMPHDSNEGPILKAWLDITRGKEPYAKKALRYFEEGLQDGNDIFALLGKVLCLEIRQNYSGALETVSQIIVNFPSFLPAFEKKMKLQLALQDWDQTVETAQRLLLQDNHNVEALRMLALYYLCREGDVEKAATKLENLGNALDVMEPQNAQLFYKITLAFSRTCGRNQLILQKVQSFLEKAFSLTPQQAEIATELGYQMILQGKVKEAWKWYRTAMTLNESNISAVTGLIRCQLIEGQLQDADQQLEFFSEFQQSMGKSAELMYLHAVLATKKNNRQDEVINLLNDVVNTHFSHLEDLPLGIQYFEKLNPDFLLEVVTEYLNLCPIQPAGPGQPLSPVLRRCSSVLETIIRSVPGLPQAVFLMAKVKYLSGDTEAAYNNLQHCLEHSPSYAEAHLLMAQVYLSQDKVKLCSQSLELCLSYNFNVREYPLYHLIKAQSQKKMGEVAEAIKTLHMAMNLPGMRRSRASSKSKHRTEVDASHRLSIFLELVEVHRLNGEQHEAAKVLQDAIHEFSGTCEELRVTIANADLALAQGDTDRALSMLRNVTTEQPYFIEAKEKMADIYLKHRKEKMLYITCYREIAERMPSPRSFLLLGDAYMNIQEPEEAIVAYEQALNQNPKDGTLARKIGKALVKTHNYSKAITYYEAALKSGQQNCLCYDLAELLLRLKLYEKAEKVLQHSLAHEPVSELSALMVDGRSQVLLAKVYSKMERPSDAIAALQQARELQARILKRVQMEQPDAVPSQKHFAAEICAEIAKHSAAQRDYEKAITFYREALVHCETDSKIMLELAQLYLAQEDLDASLRHCALLLQRDQDNEPATMLMADLMFRKQDYEQAVYHLQQLLDRKPDNFMTLSRLIDLLRRCGKLEDVPRFFLMAEKHNSRTKLEPGFQYCKGLHFWYTGEPNDALRHFNKARKDSDWGQNALYNMIEICLNPDNETIGGEVFENLNGDLGTSPEKQESVQLAVRTAEKLLKELKPQTVQGRLQLRIMENCCLMATKQKSSVEQALNTFTEIAASEKDHIPALLGMATAYMILKQTPKARNQLKRIAKMPWNPIEAEDLEKSWLLLADIYIQSAKYDMAEELLKRCLCHNRSCCKAYEYMGYIMEKEQAYTDAAFNYEMAWKHSNQTNPAVGYKLAFNYLKAKRYVDAIDVCHQVLEAHPTYPKIRKDILDKARASLRP
uniprot
proteins
function
FUNCTION: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Essential for retrograde trafficking of IFT-1, IFT-B and GPCRs (By similarity). Negatively modulates the SHH signal transduction (PubMed:18327258). {ECO:0000250|UniProtKB:Q7Z4L5, ECO:0000269|PubMed:18327258}.
uniprot
proteins
mass_dalton
150795
uniprot
proteins
protein_family
TTC21 family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18327258
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25860617
uniprot
proteins
sequence_length
1315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:18327258}. Note=In polarized epithelial inner medullary collecting ducts cells and in the nodes of mice at 8.0 dpc, colocalizes with alpha-tubulin in cilia. Expressed in a punctate manner throughout the axoneme from the cilia base to the tip.
uniprot
proteins