Cldn19
entrez
298487
canonical
uniprot
Q5QT56
canonical
ensembl
ENSRNOG00000007922
resolver
ensembl
ENSRNOG00055012448
resolver
ensembl
ENSRNOG00060016066
resolver
ensembl
ENSRNOG00065017575
resolver
ensp
ENSRNOP00000050261
resolver
ensp
ENSRNOP00000099622
resolver
genesymbol
Cldn19
resolver
uniprot
Q6AY67
resolver
uniprot_entry
CLD19_RAT
resolver
uniprot_sec
Q6AY67
resolver
amino_acid_sequence
MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPTAKGRVAISGGALFLLAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAILGGSFLCCTCPEPERANSIPQPYRSGPSTAAREPVVKLSTSVKGPLGV
uniprot
proteins
function
FUNCTION: Forms paracellular channels: coassembles with CLDN16 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (By similarity). Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption (By similarity). Forms paracellular barriers on its own. In the peripheral nervous system, represents a major constituent of the tight junctions in Schwann cells and contributes to electrical sealing. During retinal neurogenesis, may regulate the barrier properties of tight junctions in retinal pigment epithelium, required for proper retinal tissue differentiation and vision (By similarity). {ECO:0000250|UniProtKB:Q8N6F1, ECO:0000250|UniProtKB:Q9ET38}.
uniprot
proteins
mass_dalton
23315
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:Q8N6F1}. Cell membrane {ECO:0000250|UniProtKB:Q8N6F1}; Multi-pass membrane protein {ECO:0000255}. Note=Cotrafficks with CLDN16 from ER to tight junctions. Colocalizes with CLDN16 and CLDN3 in cell-cell contact areas of the TAL spatially separated from CLDN10b paracellular channels. {ECO:0000250|UniProtKB:Q8N6F1}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins