Axl
entrez
26362
canonical
uniprot
Q00993
canonical
ensembl
ENSMUSG00000002602
resolver
ensp
ENSMUSP00000002677
resolver
ensp
ENSMUSP00000083110
resolver
ensp
ENSMUSP00000318843
resolver
ensp
ENSMUSP00000318847
resolver
ensp
ENSMUSP00000318852
resolver
ensp
ENSMUSP00000318854
resolver
enst
ENSMUST00000002677
resolver
enst
ENSMUST00000085948
resolver
genesymbol
Axl
resolver
genesymbol_syn
Ark
resolver
genesymbol_syn
Ufo
resolver
uniprot
F6XEU4
resolver
uniprot
Q6PE80
resolver
uniprot
Q80YQ3
resolver
uniprot
Q8CCF8
resolver
uniprot_entry
F6XEU4_MOUSE
resolver
uniprot_entry
Q6PE80_MOUSE
resolver
uniprot_entry
Q8CCF8_MOUSE
resolver
uniprot_entry
UFO_MOUSE
resolver
uniprot_sec
Q80YQ3
resolver
activity_regulation
ACTIVITY REGULATION: Activated by GAS6-binding and subsequent autophosphorylation. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MGRVPLAWWLALCCWGCAAHKDTQTEAGSPFVGNPGNITGARGLTGTLRCELQVQGEPPEVVWLRDGQILELADNTQTQVPLGEDWQDEWKVVSQLRISALQLSDAGEYQCMVHLEGRTFVSQPGFVGLEGLPYFLEEPEDKAVPANTPFNLSCQAQGPPEPVTLLWLQDAVPLAPVTGHSSQHSLQTPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQRPHHLHVVSRQPTELEVAWTPGLSGIYPLTHCNLQAVLSDDGVGIWLGKSDPPEDPLTLQVSVPPHQLRLEKLLPHTPYHIRISCSSSQGPSPWTHWLPVETTEGVPLGPPENVSAMRNGSQVLVRWQEPRVPLQGTLLGYRLAYRGQDTPEVLMDIGLTREVTLELRGDRPVANLTVSVTAYTSAGDGPWSLPVPLEPWRPGQGQPLHHLVSEPPPRAFSWPWWYVLLGALVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVILPFMKHGDLHSFLLYSRLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPVDCLDGLYALMSRCWELNPRDRPSFAELREDLENTLKALPPAQEPDEILYVNMDEGGSHLEPRGAAGGADPPTQPDPKDSCSCLTAADVHSAGRYVLCPSTAPGPTLSADRGCPAPPGQEDGA
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269|PubMed:18083102, ECO:0000269|PubMed:20363878}.
uniprot
proteins
mass_dalton
98191
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion (By similarity). {ECO:0000250}.; PTM: Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. {ECO:0000250}.
uniprot
proteins
protein_family
AXL/UFO subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
1320243
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18083102
uniprot
proteins
pubmed
1840679
uniprot
proteins
pubmed
20363878
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7867073
uniprot
proteins
sequence_length
888
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 446..466; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins