SLC30A8
entrez
169026
canonical
uniprot
Q8IWU4
canonical
ensembl
ENSG00000164756
resolver
ensp
ENSP00000407505
resolver
ensp
ENSP00000415011
resolver
ensp
ENSP00000428545
resolver
ensp
ENSP00000431069
resolver
genesymbol
SLC30A8
resolver
genesymbol_syn
ZNT8
resolver
hgnc
HGNC:20303
resolver
uniprot
A0AVP9
resolver
uniprot
A5YM39
resolver
uniprot
B4DPE0
resolver
uniprot
Q8TCL3
resolver
uniprot_entry
ZNT8_HUMAN
resolver
uniprot_sec
A0AVP9
resolver
uniprot_sec
A5YM39
resolver
uniprot_sec
B4DPE0
resolver
uniprot_sec
Q8TCL3
resolver
amino_acid_sequence
MEFLERTYLVNDKAAKMYAFTLESVELQQKPVNKDQCPRERPEELESGGMYHCHSGSKPTEKGANEYAYAKWKLCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFSLWLSSKPPSKRLTFGWHRAEILGALLSILCIWVVTGVLVYLACERLLYPDYQIQATVMIIVSSCAVAANIVLTVVLHQRCLGHNHKEVQANASVRAAFVHALGDLFQSISVLISALIIYFKPEYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSVHSLHIWSLTMNQVILSAHVATAASRDSQVVRREIAKALSKSFTMHSLTIQMESPVDQDPDCLFCEDPCD
uniprot
proteins
function
FUNCTION: Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion. {ECO:0000269|PubMed:15331542, ECO:0000269|PubMed:16984975, ECO:0000269|PubMed:27875315, ECO:0000269|PubMed:32723473}.
uniprot
proteins
mass_dalton
40755
uniprot
proteins
mutagenesis
MUTAGEN 52..54; /note="Missing: Decreased zinc ion transmembrane transport."; /evidence="ECO:0000269|PubMed:32723473"; MUTAGEN 106; /note="H->A: Decreased zinc ion transmembrane transport; when associated with A-220."; /evidence="ECO:0000269|PubMed:32723473"; MUTAGEN 110; /note="D->N: Loss of transported zinc binding and decreased zinc ion transmembrane transport; when associated with N-224."; /evidence="ECO:0000269|PubMed:32723473"; MUTAGEN 137; /note="H->A: Decreased zinc ion transmembrane transport; when associated with A-345."; /evidence="ECO:0000269|PubMed:32723473"; MUTAGEN 220; /note="H->A: Decreased zinc ion transmembrane transport; when associated with A-106."; /evidence="ECO:0000269|PubMed:32723473"; MUTAGEN 224; /note="D->N: Loss of transported zinc binding and decreased zinc ion transmembrane transport; when associated with N-110."; /evidence="ECO:0000269|PubMed:32723473"; MUTAGEN 345; /note="H->A: Decreased zinc ion transmembrane transport; when associated with A-137."; /evidence="ECO:0000269|PubMed:32723473
uniprot
proteins
protein_family
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
uniprot
proteins
protein_family
SLC30A subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15331542
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16158222
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16984975
uniprot
proteins
pubmed
17118530
uniprot
proteins
pubmed
17293876
uniprot
proteins
pubmed
17971500
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
27875315
uniprot
proteins
pubmed
32723473
uniprot
proteins
sequence_length
369
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:15331542, ECO:0000269|PubMed:16984975}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:15331542, ECO:0000269|PubMed:16984975}; Multi-pass membrane protein {ECO:0000255}. Note=Associated with insulin and glucagon secretory granules. {ECO:0000269|PubMed:15331542}.
uniprot
proteins
transmembrane_region
TRANSMEM 80..100; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 176..196; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 218..238; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 246..266; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins