Erlin2
entrez
244373
canonical
uniprot
Q8BFZ9
canonical
ensembl
ENSMUSG00000031483
resolver
ensp
ENSMUSP00000033873
resolver
ensp
ENSMUSP00000242860
resolver
ensp
ENSMUSP00000242863
resolver
ensp
ENSMUSP00000242870
resolver
ensp
ENSMUSP00000242871
resolver
enst
ENSMUST00000033873
resolver
genesymbol
Erlin2
resolver
genesymbol_syn
Spfh2
resolver
uniprot
Q8BML8
resolver
uniprot_entry
ERLN2_MOUSE
resolver
uniprot_sec
Q8BML8
resolver
amino_acid_sequence
MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTALKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGGLGKQFEGLSDDKLGFGLEDEPLEAPTKEN
uniprot
proteins
function
FUNCTION: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity). {ECO:0000250|UniProtKB:O94905}.
uniprot
proteins
mass_dalton
37873
uniprot
proteins
post_translational_modification
PTM: Deubiquitinated by USP25; leading to stabilization. {ECO:0000250|UniProtKB:O75477}.
uniprot
proteins
protein_family
Band 7/mec-2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17502376
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21610068
uniprot
proteins
pubmed
25977983
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins