Dpy19l3
entrez
233115
canonical
uniprot
Q71B07
canonical
ensembl
ENSMUSG00000043671
resolver
ensp
ENSMUSP00000054747
resolver
enst
ENSMUST00000051377
resolver
genesymbol
Dpy19l3
resolver
uniprot
Q6PB46
resolver
uniprot
Q80W29
resolver
uniprot
Q8BLA9
resolver
uniprot
Q8BZL3
resolver
uniprot
Q8BZW5
resolver
uniprot_entry
D19L3_MOUSE
resolver
uniprot_sec
Q6PB46
resolver
uniprot_sec
Q80W29
resolver
uniprot_sec
Q8BLA9
resolver
uniprot_sec
Q8BZL3
resolver
uniprot_sec
Q8BZW5
resolver
amino_acid_sequence
MMYIRQRKETKPIEVSEDFPSPKEDVKLEKKLPSGCASGRFWKILSSAVGGTVALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLLQGFHGLIYDNKTESMRTINLLQRMNIYQEVFLSVLYRVLPIQKYLEPVYFYIYTLFGLQAVYVTALYITSWLLSGTWLSGLLAALWYVTNRIDTTRVEFTIPLRENWALPFFAIQIAAITYFLRPNLQPLSERLTLLAIFVSTFLFSLTWQFNQFMMLLQALVLFILDSLDMLPAMKATWLYGIQISCLLLVCTLQFFNSMILGSLLISFNLSVLIVRKLQKNLKTGSFLTRIWKLLLHLLLVFCLTLFLNNIIKKVLNLKSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPLNTFQRLSETLLFYAYMFVLVVTVVTASVVAFHNLSDSTSLKSMDQTRKRAVDLKPEAAYNLIHTILFGVLALSTMRMKYLWTSHMCVFASFGLCSSEVWELLLRLVHLCNPKRIWVLRYLVPVLTLLYLCYKSWPGVMDELSELKEFYDPDTVELMTWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKSLRERTQAVYQIYAKRSPEEVHALLRSFGTDFVILEDSICYERRHHRGCRLRDLLDVANGHEMDGPGESDPDLRPADHPRFCEEIKRNLPSYAAHFTRVFQNKTFHVYKLSRNK
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
function
FUNCTION: C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. The reaction occurs on the luminal side of the endoplasmic reticulum and involves the transfer of a mannose unit from a dolichylphosphate mannose (Dol-P-Man) donor to an acceptor protein containing a WxxW or WxxC consensus sequence (PubMed:28202721). C-mannosylates RSPO1, a Wnt signaling regulator, preferentially at the first Trp residue in the sequence WxxW (By similarity). C-mannosylates the netrin receptor UNC5A, preferentially at the third tryptophan of WxxWxxWxxC sequence (PubMed:28202721). {ECO:0000250|UniProtKB:Q6ZPD9, ECO:0000269|PubMed:28202721}.
uniprot
proteins
mass_dalton
82990
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:28202721}.
uniprot
proteins
protein_family
Dpy-19 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
28202721
uniprot
proteins
sequence_length
716
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:28202721}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6ZPD9}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..64; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 155..182; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 240..256; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q6ZPD9"; TRANSMEM 263..279; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q6ZPD9"; TRANSMEM 290..306; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q6ZPD9"; TRANSMEM 309..323; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q6ZPD9"; TRANSMEM 339..359; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q6ZPD9"; TRANSMEM 415..437; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q6ZPD9"; TRANSMEM 466..485; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q6ZPD9"; TRANSMEM 488..499; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q6ZPD9"; TRANSMEM 523..539; /note="Helical; Name=13"; /evidence="ECO:0000250|UniProtKB:Q6ZPD9
uniprot
proteins