CPM
entrez
1368
canonical
uniprot
P14384
canonical
ensembl
ENSG00000135678
resolver
ensp
ENSP00000339157
resolver
ensp
ENSP00000447255
resolver
ensp
ENSP00000448517
resolver
ensp
ENSP00000564672
resolver
ensp
ENSP00000564673
resolver
ensp
ENSP00000564674
resolver
ensp
ENSP00000564675
resolver
ensp
ENSP00000631628
resolver
ensp
ENSP00000631629
resolver
ensp
ENSP00000631631
resolver
ensp
ENSP00000631632
resolver
ensp
ENSP00000631633
resolver
enst
ENST00000338356
resolver
enst
ENST00000546373
resolver
enst
ENST00000551568
resolver
enst
ENST00000894614
resolver
enst
ENST00000894615
resolver
enst
ENST00000961569
resolver
enst
ENST00000961570
resolver
enst
ENST00000961572
resolver
enst
ENST00000961573
resolver
enst
ENST00000961574
resolver
genesymbol
CPM
resolver
hgnc
HGNC:2311
resolver
uniprot
B2R800
resolver
uniprot
Q9H2K9
resolver
uniprot_entry
CBPM_HUMAN
resolver
uniprot_sec
B2R800
resolver
uniprot_sec
Q9H2K9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by O-phenanthroline and MGTA and activated by cobalt.
uniprot
proteins
amino_acid_sequence
MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIHIMPSMNPDGFEAVKKPDCYYSIGRENYNQYDLNRNFPDAFEYNNVSRQPETVAVMKWLKTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGDECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLHIFFK
uniprot
proteins
ec_number
3.4.17.12
uniprot
proteins
function
FUNCTION: Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins. {ECO:0000269|PubMed:12457462}.
uniprot
proteins
mass_dalton
50514
uniprot
proteins
mutagenesis
MUTAGEN 277; /note="E->A: 5-fold decrease in substrate affinity. 22-fold decrease in specific affinity. 104-fold decrease in catalytic efficiency. Greatly reduced heat stability."; /evidence="ECO:0000269|PubMed:12457462"; MUTAGEN 277; /note="E->Q: 2-fold decrease in substrate affinity. Small increase in specific affinity. Reduced heat stability by 50%."; /evidence="ECO:0000269|PubMed:12457462"; MUTAGEN 281; /note="E->Q: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:12457462"; MUTAGEN 423; /note="S->A,T: Expressed on cell membrane. Released from membrane by PI-PLC."; /evidence="ECO:0000269|PubMed:12457462"; MUTAGEN 423; /note="S->P: Little expression on cell membrane. Perinuclear localization. Not released from membrane by PI-PLC."; /evidence="ECO:0000269|PubMed:12457462
uniprot
proteins
protein_family
Peptidase M14 family
uniprot
proteins
pubmed
11147789
uniprot
proteins
pubmed
11934264
uniprot
proteins
pubmed
12457462
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15066430
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
2753907
uniprot
proteins
sequence_length
443
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12457462}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12457462}.
uniprot
proteins