SMUG1
entrez
23583
canonical
uniprot
Q53HV7
canonical
ensembl
ENSG00000123415
resolver
ensp
ENSP00000243112
resolver
ensp
ENSP00000338606
resolver
ensp
ENSP00000421139
resolver
ensp
ENSP00000423629
resolver
ensp
ENSP00000424191
resolver
ensp
ENSP00000425974
resolver
ensp
ENSP00000507590
resolver
ensp
ENSP00000549470
resolver
ensp
ENSP00000549471
resolver
ensp
ENSP00000549472
resolver
ensp
ENSP00000549473
resolver
ensp
ENSP00000549474
resolver
ensp
ENSP00000549475
resolver
ensp
ENSP00000549477
resolver
ensp
ENSP00000549478
resolver
ensp
ENSP00000549479
resolver
ensp
ENSP00000549485
resolver
ensp
ENSP00000549486
resolver
ensp
ENSP00000549487
resolver
ensp
ENSP00000549488
resolver
ensp
ENSP00000549489
resolver
ensp
ENSP00000549492
resolver
ensp
ENSP00000549493
resolver
ensp
ENSP00000549495
resolver
ensp
ENSP00000549498
resolver
ensp
ENSP00000549500
resolver
ensp
ENSP00000549501
resolver
ensp
ENSP00000549505
resolver
ensp
ENSP00000549507
resolver
ensp
ENSP00000608217
resolver
ensp
ENSP00000608220
resolver
ensp
ENSP00000608229
resolver
enst
ENST00000514196
resolver
genesymbol
SMUG1
resolver
hgnc
HGNC:17148
resolver
uniprot
A0A024RAZ8
resolver
uniprot
A0A0S2Z526
resolver
uniprot
A8K2K9
resolver
uniprot
D6RI04
resolver
uniprot
O95862
resolver
uniprot
Q0D2M0
resolver
uniprot
Q8NB71
resolver
uniprot
Q9BWC8
resolver
uniprot_entry
A0A024RAZ8_HUMAN
resolver
uniprot_entry
A0A0S2Z526_HUMAN
resolver
uniprot_entry
D6RI04_HUMAN
resolver
uniprot_entry
SMUG1_HUMAN
resolver
uniprot_sec
A8K2K9
resolver
uniprot_sec
O95862
resolver
uniprot_sec
Q0D2M0
resolver
uniprot_sec
Q8NB71
resolver
uniprot_sec
Q9BWC8
resolver
amino_acid_sequence
MPQAFLLGSIHEPAGALMEPQPCPGSLAESFLEEELRLNAELSQLQFSEPVGIIYNPVEYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVSMVRDWLGIVGPVLTPPQEHPKRPVLGLECPQSEVSGARFWGFFRNLCGQPEVFFHHCFVHNLCPLLFLAPSGRNLTPAELPAKQREQLLGICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLMPEVQVEGLLHPSPRNPQANKGWEAVAKERLNELGLLPLLLK
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
function
FUNCTION: Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration. {ECO:0000269|PubMed:10074426, ECO:0000269|PubMed:11526119, ECO:0000269|PubMed:12161446, ECO:0000269|PubMed:12718543}.
uniprot
proteins
mass_dalton
29862
uniprot
proteins
mutagenesis
MUTAGEN 85; /note="N->A: Markedly impaired damage-excising activity for U/G, hoU/G, hmU/A and fU/A. No cytosine-excising activity for C/G, C/A, C/T and C/C."; /evidence="ECO:0000269|PubMed:15466595"; MUTAGEN 87; /note="G->A,S: Impaired the damage-excising activity for U/G, hoU/G, hmU/A and fU/A."; /evidence="ECO:0000269|PubMed:15466595"; MUTAGEN 87; /note="G->F: Loss of damage-excising activity."; /evidence="ECO:0000269|PubMed:15466595"; MUTAGEN 89; /note="F->A,G,S: No effect on damage-excising activity for U/G, hoU/G, hmU/A and fU/A."; /evidence="ECO:0000269|PubMed:15466595"; MUTAGEN 90; /note="G->A: Loss of damage-excising activity for U/G. Weak, but significant activity toward hoU/G, hmU/A and fU/A."; /evidence="ECO:0000269|PubMed:15466595"; MUTAGEN 91; /note="M->A: No effect on damage-excising activity for U/G, hoU/G, hmU/A and fU/A."; /evidence="ECO:0000269|PubMed:15466595"; MUTAGEN 98; /note="F->L: Impaired the damage-excising activity for U/G, hoU/G, hmU/A and fU/A."; /evidence="ECO:0000269|PubMed:15466595"; MUTAGEN 163; /note="N->D: Impaired the damage-excising activity for U/G, hoU/G, hmU/A and fU/A. No cytosine-excising activity for C/G, C/A, C/T and C/C. hoC-excising activity for hoC/A, hoC/T and hoC/C."; /evidence="ECO:0000269|PubMed:15466595"; MUTAGEN 239; /note="H->L,N: Markedly impaired the damage-excising activity for U/G, hoU/G, hmU/A and fU/A."; /evidence="ECO:0000269|PubMed:15466595
uniprot
proteins
protein_family
SMUG1 family
uniprot
proteins
protein_family
Uracil-DNA glycosylase (UDG) superfamily
uniprot
proteins
pubmed
10074426
uniprot
proteins
pubmed
11526119
uniprot
proteins
pubmed
12161446
uniprot
proteins
pubmed
12718543
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15466595
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10074426, ECO:0000269|PubMed:12161446}.
uniprot
proteins