Tnfrsf21
entrez
94185
canonical
uniprot
Q9EPU5
canonical
ensembl
ENSMUSG00000023915
resolver
ensp
ENSMUSP00000024708
resolver
enst
ENSMUST00000024708
resolver
genesymbol
Tnfrsf21
resolver
genesymbol_syn
Dr6
resolver
uniprot
Q3UYG3
resolver
uniprot
Q543Y9
resolver
uniprot
Q91W77
resolver
uniprot
Q91XH9
resolver
uniprot_entry
TNR21_MOUSE
resolver
uniprot_sec
Q3UYG3
resolver
uniprot_sec
Q543Y9
resolver
uniprot_sec
Q91W77
resolver
uniprot_sec
Q91XH9
resolver
amino_acid_sequence
MGTRASSITALASCSRTAGQVGATMVAGSLLLLGFLSTITAQPEQKTLSLPGTYRHVDRTTGQVLTCDKCPAGTYVSEHCTNMSLRVCSSCPAGTFTRHENGIERCHDCSQPCPWPMIERLPCAALTDRECICPPGMYQSNGTCAPHTVCPVGWGVRKKGTENEDVRCKQCARGTFSDVPSSVMKCKAHTDCLGQNLEVVKPGTKETDNVCGMRLFFSSTNPPSSGTVTFSHPEHMESHDVPSSTYEPQGMNSTDSNSTASVRTKVPSGIEEGTVPDNTSSTSGKEGTNRTLPNPPQVTHQQAPHHRHILKLLPSSMEATGEKSSTAIKAPKRGHPRQNAHKHFDINEHLPWMIVLFLLLVLVLIVVCSIRKSSRTLKKGPRQDPSAIVEKAGLKKSLTPTQNREKWIYYRNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPMPSPNVKLENSTLLTVEPSPLDKNKCFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHILNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSHLPDLL
uniprot
proteins
function
FUNCTION: Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B (PubMed:11485735, PubMed:11714751, PubMed:12515813, PubMed:21725297, PubMed:23559013). Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm (By similarity). Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP) (PubMed:23559013). Negatively regulates oligodendrocyte survival, maturation and myelination (PubMed:21725297). Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation (By similarity). Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells (By similarity). Negatively regulates the production of IgG, IgM and IgM in response to antigens (By similarity). May inhibit the activation of JNK in response to T-cell stimulation (By similarity). Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC (By similarity). {ECO:0000250|UniProtKB:O75509, ECO:0000269|PubMed:11485735, ECO:0000269|PubMed:11714751, ECO:0000269|PubMed:12515813, ECO:0000269|PubMed:21725297, ECO:0000269|PubMed:23559013}.
uniprot
proteins
mass_dalton
71983
uniprot
proteins
post_translational_modification
PTM: Oxidized in response to reactive oxygen species (ROS), leading to endocytosis. {ECO:0000250|UniProtKB:O75509}.
uniprot
proteins
pubmed
11485735
uniprot
proteins
pubmed
11714751
uniprot
proteins
pubmed
12515813
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19225519
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21725297
uniprot
proteins
pubmed
23559013
uniprot
proteins
pubmed
38110576
uniprot
proteins
sequence_length
655
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12515813}; Single-pass type I membrane protein {ECO:0000269|PubMed:12515813}. Note=Endocytosed following oxidation in response to reactive oxygen species (ROS). {ECO:0000250|UniProtKB:O75509}.
uniprot
proteins
transmembrane_region
TRANSMEM 350..370; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins