CR2
entrez
1380
canonical
uniprot
P20023
canonical
ensembl
ENSG00000117322
resolver
ensp
ENSP00000356024
resolver
ensp
ENSP00000356025
resolver
genesymbol
CR2
resolver
genesymbol_syn
C3DR
resolver
hgnc
HGNC:2336
resolver
uniprot
C9JHD2
resolver
uniprot
Q13866
resolver
uniprot
Q14212
resolver
uniprot
Q53EL2
resolver
uniprot
Q5BKT9
resolver
uniprot
Q5SR46
resolver
uniprot
Q5SR48
resolver
uniprot_entry
CR2_HUMAN
resolver
uniprot_sec
C9JHD2
resolver
uniprot_sec
Q13866
resolver
uniprot_sec
Q14212
resolver
uniprot_sec
Q53EL2
resolver
uniprot_sec
Q5BKT9
resolver
uniprot_sec
Q5SR46
resolver
uniprot_sec
Q5SR48
resolver
amino_acid_sequence
MGAAGLLGVFLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISKHRARNYYTDTSQKEAFHLEAREVYSVDPYNPAS
uniprot
proteins
disease_involvement
DISEASE: Systemic lupus erythematosus 9 (SLEB9) [MIM:610927]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269|PubMed:17360460}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Immunodeficiency, common variable, 7 (CVID7) [MIM:614699]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269|PubMed:22035880}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1 (PubMed:1849076, PubMed:21527715, PubMed:7753047). When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells (PubMed:21527715). This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling (PubMed:1383329, PubMed:30107486). Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner (PubMed:12938232). Acts as a ligand for CD23 (FcepsilonRII), a low-affinity receptor for IgE, which is expressed on B-cells and other immune cells, and thus participates in the regulation of IgE production (PubMed:1386409). {ECO:0000269|PubMed:12938232, ECO:0000269|PubMed:1383329, ECO:0000269|PubMed:1386409, ECO:0000269|PubMed:1849076, ECO:0000269|PubMed:21527715, ECO:0000269|PubMed:30107486, ECO:0000269|PubMed:7753047}.; FUNCTION: (Microbial infection) Acts as a receptor for Epstein-Barr virus. {ECO:0000269|PubMed:2460635}.
uniprot
proteins
mass_dalton
112916
uniprot
proteins
mutagenesis
MUTAGEN 103; /note="R->A: No effect on affinity for C3."; /evidence="ECO:0000269|PubMed:21527715"; MUTAGEN 112; /note="D->A: Reduced affinity for C3."; /evidence="ECO:0000269|PubMed:21527715"; MUTAGEN 128; /note="K->A: Strongly reduced affinity for C3."; /evidence="ECO:0000269|PubMed:21527715
uniprot
proteins
protein_family
Receptors of complement activation (RCA) family
uniprot
proteins
pubmed
10068037
uniprot
proteins
pubmed
11387479
uniprot
proteins
pubmed
12122212
uniprot
proteins
pubmed
12938232
uniprot
proteins
pubmed
1383329
uniprot
proteins
pubmed
1386409
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16172256
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16950392
uniprot
proteins
pubmed
1702139
uniprot
proteins
pubmed
1708808
uniprot
proteins
pubmed
17360460
uniprot
proteins
pubmed
1849076
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21527715
uniprot
proteins
pubmed
22035880
uniprot
proteins
pubmed
2460635
uniprot
proteins
pubmed
2563370
uniprot
proteins
pubmed
2827171
uniprot
proteins
pubmed
2832506
uniprot
proteins
pubmed
30107486
uniprot
proteins
pubmed
3016712
uniprot
proteins
pubmed
7753047
uniprot
proteins
pubmed
8390533
uniprot
proteins
sequence_length
1033
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1383329, ECO:0000269|PubMed:1702139}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 972..999; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins