Cdk5r1
entrez
12569
canonical
uniprot
P61809
canonical
ensembl
ENSMUSG00000048895
resolver
ensp
ENSMUSP00000099514
resolver
enst
ENSMUST00000053413
resolver
genesymbol
Cdk5r1
resolver
genesymbol_syn
Cdk5a
resolver
genesymbol_syn
Cdk5r
resolver
genesymbol_syn
Nck5a
resolver
uniprot
Q542T9
resolver
uniprot
Q62938
resolver
uniprot_entry
CD5R1_MOUSE
resolver
uniprot_entry
Q542T9_MOUSE
resolver
uniprot_sec
Q62938
resolver
amino_acid_sequence
MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKAQPNSSYQSNIAHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGVSSSVKKAPHPAITSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR
uniprot
proteins
function
FUNCTION: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:17143272, ECO:0000269|PubMed:24235147}.
uniprot
proteins
mass_dalton
34031
uniprot
proteins
mutagenesis
MUTAGEN 157; /note="E->Q: Abolishes the binding to CDK5RAP1, CDK5RAP2, CDKRAP3, but not to CDK5."; /evidence="ECO:0000269|PubMed:11882646
uniprot
proteins
post_translational_modification
PTM: The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10 fold shorter half-life compared to p25. The conversion results in deregulation of the CDK5 kinase: p25/CDK5 kinase displays an increased and altered tau phosphorylation in comparison to the p35/CDK5 kinase in vivo. {ECO:0000269|PubMed:10830966}.; PTM: Myristoylated. A proper myristoylation signal is essential for the proper distribution of p35 (By similarity). {ECO:0000250|UniProtKB:Q15078}.; PTM: Phosphorylation at Ser-8 and Thr-138 by CDK5 prevents calpain-mediated proteolysis. {ECO:0000250|UniProtKB:Q15078}.; PTM: Ubiquitinated, leading to its degradation: degradation of p35 by proteasome results in down-regulation of CDK5 activity. During this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation. Ubiquitinated by the CRL2(FEM1B) complex, which recognizes the -Gly-Leu-Asp-Arg C-degron at the C-terminus, leading to its degradation. {ECO:0000250|UniProtKB:Q15078}.
uniprot
proteins
protein_family
Cyclin-dependent kinase 5 activator family
uniprot
proteins
pubmed
10830966
uniprot
proteins
pubmed
11882646
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17143272
uniprot
proteins
pubmed
24235147
uniprot
proteins
pubmed
8661152
uniprot
proteins
sequence_length
307
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Cyclin-dependent kinase 5 activator 1, p35]: Cell membrane {ECO:0000250|UniProtKB:Q15078}; Lipid-anchor {ECO:0000250|UniProtKB:Q15078}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15078}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q15078}. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals. {ECO:0000250|UniProtKB:Q15078}.; SUBCELLULAR LOCATION: [Cyclin-dependent kinase 5 activator 1, p25]: Nucleus {ECO:0000250|UniProtKB:Q15078}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q15078}. Perikaryon {ECO:0000250|UniProtKB:Q15078}. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites. {ECO:0000250|UniProtKB:Q15078}.
uniprot
proteins