Gstp1
entrez
24426
canonical
uniprot
P04906
canonical
ensembl
ENSRNOG00000018237
resolver
ensp
ENSRNOP00000024601
resolver
enst
ENSRNOT00000024601
resolver
genesymbol
Gstp1
resolver
uniprot
B6DYQ7
resolver
uniprot_entry
B6DYQ7_RAT
resolver
uniprot_entry
GSTP1_RAT
resolver
amino_acid_sequence
MPPYTIVYFPVRGRCEATRMLLADQGQSWKEEVVTIDVWLQGSLKSTCLYGQLPKFEDGDLTLYQSNAILRHLGRSLGLYGKDQKEAALVDMVNDGVEDLRCKYGTLIYTNYENGKDDYVKALPGHLKPFETLLSQNQGGKAFIVGNQISFADYNLLDLLLVHQVLAPGCLDNFPLLSAYVARLSARPKIKAFLSSPDHLNRPINGNGKQ
uniprot
proteins
ec_number
2.5.1.18
uniprot
proteins
function
FUNCTION: Catalyzes conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000250|UniProtKB:P09211}.
uniprot
proteins
mass_dalton
23439
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by SMURF2, leading to its degradation and initiation of ferroptosis. {ECO:0000250|UniProtKB:P09211}.
uniprot
proteins
protein_family
GST superfamily
uniprot
proteins
protein_family
Pi family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2995915
uniprot
proteins
pubmed
3029128
uniprot
proteins
pubmed
3359441
uniprot
proteins
pubmed
3864155
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P09211}. Mitochondrion {ECO:0000250|UniProtKB:P09211}. Nucleus {ECO:0000250|UniProtKB:P09211}. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization. {ECO:0000250|UniProtKB:P09211}.
uniprot
proteins