Brf2
entrez
66653
canonical
uniprot
Q3UAW9
canonical
ensembl
ENSMUSG00000031487
resolver
ensp
ENSMUSP00000033877
resolver
enst
ENSMUST00000033877
resolver
genesymbol
Brf2
resolver
uniprot
A0A0R4J0C6
resolver
uniprot
Q9CZF0
resolver
uniprot_entry
A0A0R4J0C6_MOUSE
resolver
uniprot_entry
BRF2_MOUSE
resolver
uniprot_sec
Q9CZF0
resolver
amino_acid_sequence
MPNGSRCPDCGSSELVEDSHYSQSQLVCSDCGCVVTEGVLTTTFSDEGNFREVTYSRSTGENEQVSRCQQRDLRRVRDLCRILKLPLTFEDTAISYYQKAYQLSGIRAARLQKKEVLVGCCVLITCRQHNWPLTMGTICTLLYADLDLFSGTYMQMVKLLGLDVPSLCLADLVKSYCSSFKLFQASPSVPAKYVEDKDKMLSRTLLLVELADETWLVTGRHPLPIITAATFLAWQSLRPSDRLTCSLAQFCKLANVDLPYPAASRLQELLAVLLQMAGQLAWLQVLKLNKRSVVKHIGDLLQHRHMLVRTAFRDGTAEVETQQQQQQQQGQGQGQQDEVGDGPFDLPKRKRRASPTPLLPPCMLKPPKRTHTLPPESAVTGDEDISDSEIEQYLRTPQEVRDFERAQAASQAAMRVPNPP
uniprot
proteins
function
FUNCTION: General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress. {ECO:0000250|UniProtKB:Q9HAW0}.
uniprot
proteins
mass_dalton
47050
uniprot
proteins
post_translational_modification
PTM: In response to oxidative stress, Cys-362 is reversibly oxidized to cysteine sulfenic acid. Oxidation of Cys-362 impairs formation of a ternary complex with TBP and DNA and down-regulates expression of target genes in response to oxidative stress. {ECO:0000250|UniProtKB:Q9HAW0}.
uniprot
proteins
protein_family
TFIIB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9HAW0}.
uniprot
proteins