Abcb8
entrez
362302
canonical
uniprot
Q5RKI8
canonical
ensembl
ENSRNOG00000008557
resolver
ensembl
ENSRNOG00055022746
resolver
ensembl
ENSRNOG00060022506
resolver
ensembl
ENSRNOG00065017438
resolver
ensp
ENSRNOP00000012222
resolver
ensp
ENSRNOP00055031717
resolver
ensp
ENSRNOP00060032329
resolver
ensp
ENSRNOP00065023102
resolver
enst
ENSRNOT00000012222
resolver
enst
ENSRNOT00055039052
resolver
enst
ENSRNOT00060039098
resolver
enst
ENSRNOT00065029153
resolver
genesymbol
Abcb8
resolver
genesymbol_syn
Mitosur
resolver
uniprot
Q0QVT4
resolver
uniprot_entry
MITOS_RAT
resolver
uniprot_sec
Q0QVT4
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity inhibited by ATP via ABCB8/MITOSUR subunit. {ECO:0000250|UniProtKB:Q9NUT2}.
uniprot
proteins
amino_acid_sequence
MLVHLFRVGIRGGPVPRWSLQSLRFQTFSAARSSDDQFSSCLLRAVAQLRSQLRAHLPRSPPASHRSTSAWCWVGGTLVVPAVLWQHPRFCLIALCEAKGSPPAQPTRARELRFKWKLFWHFLHPHLLALGLAIVLALGAALVNVQIPLLLGQLVEIVAKYTREHVGSFVSESRRLSIQLLLLYGVQGLLTFGYLVLLSHMGERMAMDMRKALFSSLLRQDIAFFDAKKTGQLVSRLTTDVQEFKSSFKLVISQGLRSSTQVIGSLMTLSILSPRLTLMLAVVTPALMGVGTLMGSGLRKLSRQCQEQIARATGVADEALGSVRTVRAFAMEKREEERYQAELESCCCKAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLKGGDLMSFLVASQTVQRSMASLSVLFGQVVRGLSAGARVFEYMSLSPVIPLTGGYSIPSKDLRGSITFQNVSFSYPCRPGFNVLKNFTLKLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVTLDGHDLRTLDPSWLRGQVIGFISQEPVLFATTIMENIRFGKLDASDEEVYTAARKANAHEFISSFPDGYSTVVGERGTTLSGGQKQRLAIARALIKRPTVLILDEATSALDAESERIVQEALDRASAGRTVLVIAHRLSTVRAAHSIIVMANGQVCEAGTHEELLQKGGLYAELIRRQALDASLPSAPPAEKPEDHRSCQ
uniprot
proteins
function
FUNCTION: ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). v. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix (By similarity). Plays a role in mitochondrial iron transport (By similarity). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity). {ECO:0000250|UniProtKB:Q9CXJ4, ECO:0000250|UniProtKB:Q9NUT2}.
uniprot
proteins
mass_dalton
77770
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCB family
uniprot
proteins
protein_family
Multidrug resistance exporter (TC 3.A.1.201) subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16390497
uniprot
proteins
sequence_length
714
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9NUT2}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
uniprot
proteins
transmembrane_region
TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 178..198; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 278..298; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 365..385; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins