Swap70
entrez
20947
canonical
uniprot
Q6A028
canonical
ensembl
ENSMUSG00000031015
resolver
ensp
ENSMUSP00000033325
resolver
enst
ENSMUST00000033325
resolver
genesymbol
Swap70
resolver
genesymbol_syn
Kiaa0640
resolver
uniprot
O88443
resolver
uniprot
Q3TQR6
resolver
uniprot
Q3UCA3
resolver
uniprot
Q6P1D0
resolver
uniprot_entry
SWP70_MOUSE
resolver
uniprot_sec
O88443
resolver
uniprot_sec
Q3TQR6
resolver
uniprot_sec
Q3UCA3
resolver
uniprot_sec
Q6P1D0
resolver
amino_acid_sequence
MRGLKDELLKAIWHAFTALDLDRSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEGPVSNQGYMPYLNKFILEKVQDNFDKIEFNRMCWTLCVKKNLTKSPLLITEDDAFKVWVIFNFLSEDKYPLIIVPEEIEYLLKKLTEAMGGGWQQEQFEHYKINFDDNKDGLSAWELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHKRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLIKCFDKTFEISASDKKKKQEWIQAIYSTIHLLKLGSPPPHKEARQRRKELRRKLLAEQEELERQMKELQAANENKQQELESVRKKLEEAASRAADEEKKRLQTQVELQTRFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELEQQRVMKEQALQEAMAQLEQLELERKQALEQYEGVKKKLEMATHMTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTQAELEEREKSWKEKKTTE
uniprot
proteins
function
FUNCTION: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
68996
uniprot
proteins
post_translational_modification
PTM: Tyrosine-phosphorylated. {ECO:0000250}.
uniprot
proteins
pubmed
10382743
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9642267
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10382743}. Cell membrane {ECO:0000250|UniProtKB:Q9UH65}. Nucleus {ECO:0000269|PubMed:10382743, ECO:0000269|PubMed:9642267}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9UH65}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9UH65}. Note=Localizes predominantly to the nucleus in activated cells. Only a small amount can be detected in the cytoplasm. {ECO:0000269|PubMed:10382743}.
uniprot
proteins