Cdk14
entrez
18647
canonical
uniprot
O35495
canonical
ensembl
ENSMUSG00000028926
resolver
ensp
ENSMUSP00000030763
resolver
ensp
ENSMUSP00000111110
resolver
ensp
ENSMUSP00000111111
resolver
ensp
ENSMUSP00000111112
resolver
enst
ENSMUST00000115452
resolver
genesymbol
Cdk14
resolver
genesymbol_syn
Kiaa0834
resolver
genesymbol_syn
Pftk1
resolver
uniprot
E9PVC7
resolver
uniprot
O35848
resolver
uniprot
Q3TNN9
resolver
uniprot
Q3V319
resolver
uniprot
Q6NVF8
resolver
uniprot
Q6ZQ37
resolver
uniprot
Q8BFX6
resolver
uniprot_entry
CDK14_MOUSE
resolver
uniprot_entry
E9PVC7_MOUSE
resolver
uniprot_entry
Q6NVF8_MOUSE
resolver
uniprot_entry
Q8BFX6_MOUSE
resolver
uniprot_sec
O35848
resolver
uniprot_sec
Q3TNN9
resolver
uniprot_sec
Q3V319
resolver
uniprot_sec
Q6ZQ37
resolver
activity_regulation
ACTIVITY REGULATION: Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKEDTTFDEICVTKMSTRNCQGTDSVIKHLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKSSSAGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTVYSSKSLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH
uniprot
proteins
ec_number
2.7.11.22
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport (By similarity). {ECO:0000250, ECO:0000269|PubMed:9547506}.
uniprot
proteins
mass_dalton
52996
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9202329
uniprot
proteins
pubmed
9547506
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY. {ECO:0000250}.
uniprot
proteins