Stam2
entrez
311030
canonical
uniprot
Q5XHY7
canonical
ensembl
ENSRNOG00000027447
resolver
ensp
ENSRNOP00000080484
resolver
enst
ENSRNOT00000115523
resolver
genesymbol
Stam2
resolver
uniprot_entry
STAM2_RAT
resolver
amino_acid_sequence
MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDRVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKAMKEEGVTFPSAGSQTVSAAAKNGASLNKNKEDEDIAKAIELSLQEQKQQYPETKALCPPAESQLSNKVARRVRALYDFEAVEDNELTFKHGEIITVLDDSDANWWEGENHRGAGLFPSSFVTTDLSTEVEAATVDKSNVIDDDVEEIKKSEPEPVYIDEGKMDRALQILQSIDPKDPKPDSQDLLDLEDICQQMGPMIDEKLEEIDRRHSELSELNVKVLEALELYNKLVNEAPMYSVYSKLHPAPYSATAAGVPVQTYPVQSHGGNYLGHGIHQVPVAQSYNLGPDPMGSSRSLPPNMNSVTAHTIQPPYLSTGQDAVSNPSYMTQSSHLQAAAGTAAYTPAMGVSADLSSFQSTASGLPQLAGFPVAVPVPPAPQPQASYHQQPLL
uniprot
proteins
function
FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250, ECO:0000269|PubMed:11062024}.
uniprot
proteins
mass_dalton
57159
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
STAM family
uniprot
proteins
pubmed
11062024
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
uniprot
proteins