Pdcd10
entrez
56426
canonical
uniprot
Q8VE70
canonical
ensembl
ENSMUSG00000027835
resolver
ensp
ENSMUSP00000125752
resolver
enst
ENSMUST00000161137
resolver
genesymbol
Pdcd10
resolver
genesymbol_syn
Tfar15
resolver
uniprot
Q9DAR3
resolver
uniprot
Q9WV43
resolver
uniprot_entry
PDC10_MOUSE
resolver
uniprot_sec
Q9DAR3
resolver
uniprot_sec
Q9WV43
resolver
amino_acid_sequence
MRMTMEEMKNEAETTSMVSMPLYAVMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIIMKILEKKSVEVNFTESLLRMAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELLDTVNNVFKKYQYQNRRALEHQKKEFVKYSKSFSDTLKTYFKDGKAINVFISANRLIHQTNLILQTFKTVA
uniprot
proteins
function
FUNCTION: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (By similarity). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown (PubMed:20371769). Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). {ECO:0000250|UniProtKB:Q9BUL8, ECO:0000269|PubMed:20371769}.
uniprot
proteins
mass_dalton
24716
uniprot
proteins
protein_family
PDCD10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20371769
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BUL8}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q6NX65}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NX65}; Cytoplasmic side {ECO:0000250|UniProtKB:Q6NX65}. Cell membrane {ECO:0000269|PubMed:20371769}; Peripheral membrane protein {ECO:0000269|PubMed:20371769}; Cytoplasmic side {ECO:0000269|PubMed:20371769}.
uniprot
proteins