CLDN15
entrez
24146
canonical
uniprot
P56746
canonical
ensembl
ENSG00000106404
resolver
ensp
ENSP00000308870
resolver
ensp
ENSP00000385300
resolver
enst
ENST00000308344
resolver
enst
ENST00000401528
resolver
genesymbol
CLDN15
resolver
hgnc
HGNC:2036
resolver
uniprot
B3KPB5
resolver
uniprot_entry
CLD15_HUMAN
resolver
uniprot_sec
B3KPB5
resolver
amino_acid_sequence
MSMAVETFGFFMATVGLLMLGVTLPNSYWRVSTVHGNVITTNTIFENLWFSCATDSLGVYNCWEFPSMLALSGYIQACRALMITAILLGFLGLLLGIAGLRCTNIGGLELSRKAKLAATAGALHILAGICGMVAISWYAFNITRDFFDPLYPGTKYELGPALYLGWSASLISILGGLCLCSACCCGSDEDPAASARRPYQAPVSVMPVATSDQEGDSSFGKYGRNAYV
uniprot
proteins
function
FUNCTION: Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:12055082, PubMed:13129853, PubMed:31188544, PubMed:35650657, PubMed:36008380). In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and intestinal morphogenesis (By similarity). {ECO:0000250|UniProtKB:Q9Z0S5, ECO:0000269|PubMed:12055082, ECO:0000269|PubMed:13129853, ECO:0000269|PubMed:31188544, ECO:0000269|PubMed:35650657, ECO:0000269|PubMed:36008380}.
uniprot
proteins
mass_dalton
24356
uniprot
proteins
mutagenesis
MUTAGEN 46; /note="E->K: No effect on charge selectivity for paracellular ion transport."; /evidence="ECO:0000269|PubMed:12055082"; MUTAGEN 55; /note="D->N: Decreases ion conductance and cation selectivity. Strongly reduces Na(+)-selective paracellular transport; when associated with Q-64. Does not affect the integration into tight junction strands."; /evidence="ECO:0000269|PubMed:35650657"; MUTAGEN 55; /note="D->R: Reverses the charge selectivity for paracellular ion transport, favoring Cl(-) transport."; /evidence="ECO:0000269|PubMed:12055082"; MUTAGEN 63; /note="W->K: Does not affect assembly into homopolymeric strands, ion conductance, charge selectivity or pore size."; /evidence="ECO:0000269|PubMed:35650657"; MUTAGEN 64; /note="E->K: Impairs the charge selectivity for paracellular ion transport, favoring Cl(-) transport."; /evidence="ECO:0000269|PubMed:12055082"; MUTAGEN 64; /note="E->Q: Decreases ion conductance and cation selectivity. Strongly reduces Na(+)-selective paracellular transport; when associated with N-55. Does not affect the integration into tight junction strands."; /evidence="ECO:0000269|PubMed:35650657
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. {ECO:0000250|UniProtKB:Q9Z0S5}.
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
12055082
uniprot
proteins
pubmed
13129853
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
31188544
uniprot
proteins
pubmed
35650657
uniprot
proteins
pubmed
36008380
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:31188544, ECO:0000269|PubMed:35650657}. Cell membrane {ECO:0000269|PubMed:31188544, ECO:0000269|PubMed:35650657}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 2..24; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 75..99; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 116..140; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 160..182; /note="Helical"; /evidence="ECO:0000250
uniprot
proteins