LILRB4
entrez
11006
canonical
uniprot
Q8NHJ6
canonical
ensembl
ENSG00000186818
resolver
ensembl
ENSG00000275730
resolver
ensp
ENSP00000375613
resolver
ensp
ENSP00000375614
resolver
ensp
ENSP00000375616
resolver
ensp
ENSP00000401962
resolver
ensp
ENSP00000408995
resolver
ensp
ENSP00000481609
resolver
ensp
ENSP00000511897
resolver
ensp
ENSP00000527415
resolver
ensp
ENSP00000527416
resolver
ensp
ENSP00000640023
resolver
ensp
ENSP00000640025
resolver
ensp
ENSP00000640026
resolver
ensp
ENSP00000640027
resolver
enst
ENST00000391733
resolver
enst
ENST00000391734
resolver
enst
ENST00000391736
resolver
enst
ENST00000430952
resolver
enst
ENST00000619525
resolver
enst
ENST00000695418
resolver
genesymbol
LILRB4
resolver
genesymbol_syn
ILT3
resolver
genesymbol_syn
LIR5
resolver
hgnc
HGNC:6608
resolver
uniprot
A0A0A0MS20
resolver
uniprot
A0A0A0MSZ8
resolver
uniprot
A0A0G2JNL1
resolver
uniprot
A0A8Q3SHR1
resolver
uniprot
A8MUE1
resolver
uniprot
A8MVL8
resolver
uniprot
O15468
resolver
uniprot
O75021
resolver
uniprot
Q6FGQ9
resolver
uniprot
Q8N1C7
resolver
uniprot
Q8NHL5
resolver
uniprot_entry
A0A0A0MS20_HUMAN
resolver
uniprot_entry
A0A0A0MSZ8_HUMAN
resolver
uniprot_entry
A0A0G2JNL1_HUMAN
resolver
uniprot_entry
A0A8Q3SHR1_HUMAN
resolver
uniprot_entry
A8MUE1_HUMAN
resolver
uniprot_entry
LIRB4_HUMAN
resolver
uniprot_sec
A8MVL8
resolver
uniprot_sec
O15468
resolver
uniprot_sec
O75021
resolver
uniprot_sec
Q6FGQ9
resolver
uniprot_sec
Q8N1C7
resolver
uniprot_sec
Q8NHL5
resolver
amino_acid_sequence
MIPTFTALLCLGLSLGPRTHMQAGPLPKPTLWAEPGSVISWGNSVTIWCQGTLEAREYRLDKEESPAPWDRQNPLEPKNKARFSIPSMTEDYAGRYRCYYRSPVGWSQPSDPLELVMTGAYSKPTLSALPSPLVTSGKSVTLLCQSRSPMDTFLLIKERAAHPLLHLRSEHGAQQHQAEFPMSPVTSVHGGTYRCFSSHGFSHYLLSHPSDPLELIVSGSLEDPRPSPTRSVSTAAGPEDQPLMPTGSVPHSGLRRHWEVLIGVLVVSILLLSLLLFLLLQHWRQGKHRTLAQRQADFQRPPGAAEPEPKDGGLQRRSSPAADVQGENFCAAVKNTQPEDGVEMDTRQSPHDEDPQAVTYAKVKHSRPRREMASPPSPLSGEFLDTKDRQAEEDRQMDTEAAASEAPQDVTYAQLHSFTLRQKATEPPPSQEGASPAEPSVYATLAIH
uniprot
proteins
function
FUNCTION: Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed:11875462). Receptor for FN1 (PubMed:34089617). Receptor for apolipoprotein APOE (PubMed:30333625). Receptor for ALCAM/CD166 (PubMed:29263213). Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:9151699). Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed:19833736). This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617). Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytotoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed:16493035, PubMed:19833736, PubMed:29263213). Induces up-regulation of CD86 on dendritic cells (PubMed:19860908). Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed:11875462). {ECO:0000269|PubMed:11875462, ECO:0000269|PubMed:16493035, ECO:0000269|PubMed:19833736, ECO:0000269|PubMed:19860908, ECO:0000269|PubMed:29263213, ECO:0000269|PubMed:30333625, ECO:0000269|PubMed:34089617, ECO:0000269|PubMed:9151699}.
uniprot
proteins
mass_dalton
49356
uniprot
proteins
mutagenesis
MUTAGEN 30; /note="T->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 35; /note="P->A: Significant reduction in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 41; /note="W->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 59; /note="R->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 63; /note="E->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 64; /note="E->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 65; /note="S->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 66; /note="P->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 68; /note="P->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 91; /note="D->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 95; /note="R->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 97; /note="R->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 103; /note="P->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 106; /note="W->A: Significant reduction in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 109; /note="P->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 111; /note="D->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 112; /note="P->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 113; /note="L->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 114; /note="E->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 121; /note="Y->A: Significant reduction in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 122; /note="S->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 147; /note="R->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 149; /note="P->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 162; /note="H->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 164; /note="L->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 165; /note="L->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 167; /note="L->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 170; /note="E->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 183; /note="S->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 184; /note="P->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 186; /note="T->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 188; /note="V->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 199; /note="H->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 201; /note="F->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625"; MUTAGEN 202; /note="S->A: No significant change in APOE-mediated activation of LILRB4."; /evidence="ECO:0000269|PubMed:30333625
uniprot
proteins
pubmed
10941837
uniprot
proteins
pubmed
11875462
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16493035
uniprot
proteins
pubmed
19833736
uniprot
proteins
pubmed
19860908
uniprot
proteins
pubmed
21454581
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29263213
uniprot
proteins
pubmed
30333625
uniprot
proteins
pubmed
34089617
uniprot
proteins
pubmed
9151699
uniprot
proteins
pubmed
9278324
uniprot
proteins
pubmed
9548455
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19833736, ECO:0000269|PubMed:9151699}; Single-pass type I membrane protein {ECO:0000269|PubMed:9151699}. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment. {ECO:0000269|PubMed:9151699}.
uniprot
proteins
transmembrane_region
TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins