CCNC
entrez
892
canonical
uniprot
P24863
canonical
ensembl
ENSG00000112237
resolver
ensp
ENSP00000319027
resolver
ensp
ENSP00000427885
resolver
ensp
ENSP00000428982
resolver
ensp
ENSP00000430014
resolver
ensp
ENSP00000430294
resolver
ensp
ENSP00000430381
resolver
ensp
ENSP00000487040
resolver
ensp
ENSP00000671963
resolver
ensp
ENSP00000671965
resolver
enst
ENST00000326298
resolver
enst
ENST00000518714
resolver
enst
ENST00000520371
resolver
enst
ENST00000627680
resolver
genesymbol
CCNC
resolver
hgnc
HGNC:1581
resolver
uniprot
B4DPZ1
resolver
uniprot
E5RFK5
resolver
uniprot
G5E954
resolver
uniprot
Q7Z4L3
resolver
uniprot
Q9H543
resolver
uniprot_entry
CCNC_HUMAN
resolver
uniprot_entry
E5RFK5_HUMAN
resolver
uniprot_entry
G5E954_HUMAN
resolver
uniprot_entry
Q7Z4L3_HUMAN
resolver
uniprot_sec
B4DPZ1
resolver
uniprot_sec
Q9H543
resolver
amino_acid_sequence
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
uniprot
proteins
function
FUNCTION: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinases CDK8 and CDK19 that phosphorylate the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. {ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:25344755, ECO:0000269|PubMed:8700522}.
uniprot
proteins
mass_dalton
33243
uniprot
proteins
protein_family
Cyclin C subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
10024883
uniprot
proteins
pubmed
10993082
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15175163
uniprot
proteins
pubmed
16595664
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
1833066
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
21806996
uniprot
proteins
pubmed
25344755
uniprot
proteins
pubmed
8700522
uniprot
proteins
pubmed
8833152
uniprot
proteins
pubmed
9734358
uniprot
proteins
sequence_length
283
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins