Pex6
entrez
224824
canonical
uniprot
Q99LC9
canonical
ensembl
ENSMUSG00000002763
resolver
ensp
ENSMUSP00000002840
resolver
enst
ENSMUST00000002840
resolver
genesymbol
Pex6
resolver
uniprot
Q6YNQ9
resolver
uniprot_entry
PEX6_MOUSE
resolver
uniprot_sec
Q6YNQ9
resolver
amino_acid_sequence
MALAVLRVLDPFPTETPPLAVLLPPGGPWPATGLGLVLALRPASESPAKPALLVAAVEGSGAQGEQRGPGPPPLLVSRALLRVLALGPGARVRARLVRRPPALGWALLATAPGPGLGPRVGPLLVRRGETLPVPGSRVLETRPALQGLLGPGTRLAVTELRGRAKLGQESRDHSHPPPPPVVSSFAASHSVRRLRGVLGGTGDALGVSRSCLRSLGLFQGEWVWVAQVAELPNSSQPRLAQVQVLEPRWELSERLGPNSGQQPGEPLADGLVFLPATLAFNLGCDPLEVGELRIQRYLEGSIAPENKGSCSPLPGPPFARELHIEILSSPHYSANGNYDHVLYRHFQTPRVVQEGDVLCVSTAGQVEILEGSLERLPRWREMFFKVKKTVGEAPEGPASAFLADTTHTSLYLAGTALSHVPSLPSGRSPPWDSLSPPGLEALVNELCAILKPHLQPGGTLLTGTSCVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLGRDRDGLGEDARVAATLRHLLLDEDALSRCPPLMVVATTSRVQDLPTDVQTAFPHELEVPVLSEAQRLSILQALTAHLPLGQEVNLPQLARRCAGFVVGDLYALLTHTCRAACTRIRASGSAGGLSEEDEGDLCVAGFPLLAEDFGQALDQLQTAHSQAVGAPRIPSVSWHDVGGLQDVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGASEDRASQLRVLSAITRKFKLEASVSLANVLDCCPPQLTGADLYSLCSDAMMTALKRRVRDLEEGLELRSSALLLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAAC
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5. {ECO:0000250|UniProtKB:Q13608}.
uniprot
proteins
mass_dalton
104549
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26593283
uniprot
proteins
pubmed
27302843
uniprot
proteins
sequence_length
981
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q13608}. Peroxisome membrane {ECO:0000250|UniProtKB:Q13608}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:26593283}. Note=Associated with peroxisomal membranes; anchored by PEX26 to peroxisome membranes (By similarity). Localized at the base of the outer segment of photoreceptor cells (PubMed:26593283). {ECO:0000250|UniProtKB:Q13608, ECO:0000269|PubMed:26593283}.
uniprot
proteins