Megf10
entrez
70417
canonical
uniprot
Q6DIB5
canonical
ensembl
ENSMUSG00000024593
resolver
ensp
ENSMUSP00000075174
resolver
enst
ENSMUST00000075770
resolver
genesymbol
Megf10
resolver
uniprot
Q3TLU3
resolver
uniprot
Q3UG73
resolver
uniprot_entry
MEG10_MOUSE
resolver
uniprot_sec
Q3TLU3
resolver
uniprot_sec
Q3UG73
resolver
amino_acid_sequence
MAISSSSCLGLICSLLCHWVGTASSLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRISYRTAYRHGEKTMYRRKSQCCPGFYESRDMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCSSRCQCKNRALCNPITGACHCAAGYRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHITGECRCSPGYTGAFCEDLCPPGKHGPHCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGSYGVRCAEACRCVNGGKCYHVSGTCLCEAGFSGELCEARLCPEGLYGIKCDKRCPCHLDNTHSCHPMSGECGCKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGRCACAPGFKGTDCSTPCPLGRYGINCSSRCGCKNDAVCSPVDGSCICKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGAKCEFPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGVCTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPAGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPADSYQIGAIAGIVVLVLVVLFLLALFIIYRHKQKRKESSMPAVTYTPAMRVINADYTIAETLPHSNGGNANSHYFTNPSYHTLSQCATSPHVNNRDRMTIAKSKNNQLFVNLKNVNPGKRGTLVDCTGTLPADWKQGGYLNELGAFGLDRSYMGKSLKDLGKNSEYNSSTCSLSSSENPYATIKDPPALLPKSSECGYVEMKSPARRDSPYAEINNSTPANRNVYEVEPTVSVVQGVFSNSGHVTQDPYDLPKNSHIPCHYDLLPVRDSSSSPKREDGGGSNSTSSNSTSSSSSSSE
uniprot
proteins
function
FUNCTION: Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells (PubMed:27170117). Cooperates with ABCA1 within the process of engulfment (By similarity). Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides (PubMed:20828568). Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum (PubMed:27170117). Plays a role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:28498977, Ref.10). May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (PubMed:22407321). {ECO:0000250|UniProtKB:Q96KG7, ECO:0000269|PubMed:18056409, ECO:0000269|PubMed:20828568, ECO:0000269|PubMed:22407321, ECO:0000269|PubMed:27170117, ECO:0000269|PubMed:28498977, ECO:0000269|Ref.10}.
uniprot
proteins
mass_dalton
122972
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; mono- and polyubiquitinated forms are detected. {ECO:0000250|UniProtKB:Q96KG7}.; PTM: Phosphorylated on tyrosine residues. Phosphorylation at Tyr-1030 may be important for muscle cell proliferation. {ECO:0000250|UniProtKB:Q96KG7}.
uniprot
proteins
protein_family
MEGF family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17205124
uniprot
proteins
pubmed
17643423
uniprot
proteins
pubmed
18056409
uniprot
proteins
pubmed
20828568
uniprot
proteins
pubmed
22407321
uniprot
proteins
pubmed
27170117
uniprot
proteins
pubmed
28498977
uniprot
proteins
sequence_length
1147
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17643423, ECO:0000269|PubMed:28498977}; Single-pass type I membrane protein {ECO:0000269|PubMed:17643423}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q96KG7}. Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell surface that becomes firmely fixed to the substrate. Expressed at the cell surface in clusters around cell corpses during engulfment. During the engulfment of apoptotic thymocytes, recruited at the bottom of the forming phagocytic cup. Colocalizes with ABCA1 in absence of any phagocytic challenge. Does not localize within lamellipodia. Does not localize with MEGF11 (By similarity). Enriched at the sites of contact with apoptotic thymocyte cells. {ECO:0000250|UniProtKB:Q96KG7}.
uniprot
proteins
transmembrane_region
TRANSMEM 858..878; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins