Clstn1
entrez
313717
canonical
uniprot
Q6Q0N0
canonical
ensembl
ENSRNOG00000016398
resolver
ensp
ENSRNOP00000047223
resolver
ensp
ENSRNOP00000086858
resolver
ensp
ENSRNOP00000089605
resolver
enst
ENSRNOT00000045063
resolver
enst
ENSRNOT00000113486
resolver
enst
ENSRNOT00000119851
resolver
genesymbol
Clstn1
resolver
genesymbol_syn
Cs1
resolver
uniprot
A0A8I6AC41
resolver
uniprot
A0A8I6GFE6
resolver
uniprot
A0A8L2QPW4
resolver
uniprot_entry
A0A8I6AC41_RAT
resolver
uniprot_entry
A0A8I6GFE6_RAT
resolver
uniprot_entry
A0A8L2QPW4_RAT
resolver
uniprot_entry
CSTN1_RAT
resolver
amino_acid_sequence
MLRRPAPALARAVRLLLAGLLYGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDSPLRFAGEICGFKIHGQNVPFDAVVVDKSTGEGIIRSKEKLDCELQKDYTFTIQAYDCGKGPDGTGVKKSHKATVHIQVNDVNEYAPVFKEKSYKAAVVEGKQHGSILRVEAVDADCSPQFSQICSYEILTPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISVKPTCSPGWQGWSSRIEYEPGTGALAVFPSIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTSELLPSPSSSFNWTVGLPTDNGHDSDQVFEFNGTQAVRIPDGVVTLDPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLLRQDPSEEKKYRPAEFHWKLNQVCDEDWHHFVLNVEVPSVTLYVDGVSHEPFSVTEDYPLHPTKIETQLVVGACWQGGDLHMTQFFRGNLAGLTVRSGKLADKKVIDCLYTCKEGLDLQVPEDGNRGVQIQTSSSQAVLTLEGENVGELDKAMQHISYLNSRQFPTPGIRRLKITSTVKCFNEAACIEVPPVEGYVMVLQPEEPKISLSGVHHFARAASEFESPEGVSLFPELKIISTITREVEPEADGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNAEQESLEVDVARLQQKGIEVNHSDLGVVFTGVETMASYEEVLHLLRYRNWHTRSLLDRKFKLICSELNGRYLSNEFKVEVNVIHTANPVEHANHMAAQPQFVHPEHRSFVDLSGHNLASPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHQRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEEDITSAESESSEEEEGGPGDGQNTTRQQQLEWDYSTLSY
uniprot
proteins
function
FUNCTION: Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (By similarity). {ECO:0000250|UniProtKB:O94985, ECO:0000250|UniProtKB:Q99JH7, ECO:0000250|UniProtKB:Q9EPL2}.; FUNCTION: [Soluble Alc-alpha]: As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. {ECO:0000250|UniProtKB:O94985}.; FUNCTION: [CTF1-alpha]: In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. {ECO:0000250|UniProtKB:O94985}.
uniprot
proteins
mass_dalton
106261
uniprot
proteins
post_translational_modification
PTM: Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by presenilin gamma-secretase within the transmembrane domain releases the beta-Alc-alpha chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1. {ECO:0000250|UniProtKB:O94985}.
uniprot
proteins
protein_family
Calsyntenin family
uniprot
proteins
pubmed
11161476
uniprot
proteins
pubmed
15326124
uniprot
proteins
pubmed
26479776
uniprot
proteins
sequence_length
952
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:11161476}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O94985}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O94985}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, neuron projection {ECO:0000250|UniProtKB:O94985}. Note=Localized in the postsynaptic membrane of both excitatory and inhibitory synapses. {ECO:0000250|UniProtKB:Q9EPL2}.; SUBCELLULAR LOCATION: [Soluble Alc-alpha]: Nucleus {ECO:0000250|UniProtKB:O94985}. Note=The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. {ECO:0000250|UniProtKB:O94985}.
uniprot
proteins
transmembrane_region
TRANSMEM 831..851; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins