Chaf1b
entrez
110749
canonical
uniprot
Q9D0N7
canonical
ensembl
ENSMUSG00000022945
resolver
ensp
ENSMUSP00000023666
resolver
ensp
ENSMUSP00000113684
resolver
enst
ENSMUST00000023666
resolver
enst
ENSMUST00000117099
resolver
genesymbol
Chaf1b
resolver
uniprot_entry
CAF1B_MOUSE
resolver
amino_acid_sequence
MKVITCEIAWHNKEPVYSLDFQHGATWKIHRLASAGVDTAVRIWKLERGPDGKAIVEFLSNLARHTKAVNVVRFSPTGEILASGGDDAVILLWKMNDSKEPEQIAFQDEEEAQLNKENWTVVKTLRGHLEDVYDICWATDGNLMTSASVDNTVIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYIATLSCDRVLRIYNTQKKRVAFNISKMLSGQGPEGEARSFRMFHDDSMKSFFRRLSFTPDGSLLLTPAGCMESGENVTNTTYVFSRKHLKRPIAHLPCPGKATLAVRCCPVYFELRPVAETEKASEEPSPELVNLPYRMVFAVASEDSVLLYDTQQSFPFGYVSNIHYHTLSDISWSSDGAFLAISSTDGYCTFVTFEKGELGIPLKEKPVLSIRTPDTAKKAKNQTHQGSSPGSRSVEGTPSNRTQDPSSPCTTPSPTTQSPAPSAIKDSPSAIPAGKSPLPQPSEEKTLQPAGQNMKAPQPRRVTLNTLQTWGKTAPRRINLTPLKTDTVPNPQPNSGTAPSTEEVQPEAPGEPPEEPPELKRPRLEEREGDAQNLAPDDSSKTV
uniprot
proteins
function
FUNCTION: Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer (By similarity). {ECO:0000250|UniProtKB:Q13112, ECO:0000250|UniProtKB:Q5R1S9}.
uniprot
proteins
mass_dalton
63132
uniprot
proteins
protein_family
WD repeat HIR1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13112}. Cytoplasm {ECO:0000250|UniProtKB:Q13112}. Note=DNA replication foci. Cytoplasmic in M phase. {ECO:0000250|UniProtKB:Q13112}.
uniprot
proteins