Slc7a9
entrez
116726
canonical
uniprot
P82252
canonical
ensembl
ENSRNOG00000012344
resolver
ensembl
ENSRNOG00055005563
resolver
ensembl
ENSRNOG00060029980
resolver
ensembl
ENSRNOG00065032084
resolver
ensp
ENSRNOP00000016919
resolver
ensp
ENSRNOP00055006805
resolver
ensp
ENSRNOP00060043312
resolver
ensp
ENSRNOP00065045457
resolver
enst
ENSRNOT00000016919
resolver
enst
ENSRNOT00055008939
resolver
enst
ENSRNOT00060052077
resolver
enst
ENSRNOT00065055266
resolver
genesymbol
Slc7a9
resolver
genesymbol_syn
Bat1
resolver
uniprot
Q4KM04
resolver
uniprot_entry
BAT1_RAT
resolver
uniprot_sec
Q4KM04
resolver
amino_acid_sequence
MEETSPRRRREDEKSVHSTEPKTTSLQKEVGLLSGICIIVGTIIGSGIFISPKSVLANTESVGPCLIIWAACGVLATLGALCFAELGTMITKSGGEYPYLMEAFGPIPAYLFSWTSLIVMKPSSFAIICLSFSEYVCAAFYLGCRPPAVVVKLLAAAAILLITTVNALSVRLGSYVQNVFTAAKLVIVAIIIISGLVLLAQGNVKNFQNSFEGSQTSVGSISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPMAIVIGIPLVTVCYILMNIAYFTVMTPTELLQSQAVAVTFGDRVLYPASWVVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVKRLTPAPALVFYGIIAIIYIIPGDINSLVNYFSFAAWLFYGMTILGLVVMRFTRKDLERPIKVPIFIPIIVILVSVFLILAPIISSPAWEYLYCVLFILSGLIFYFLFVHYKFRWAQKISRPITKHLQMLMEVVPPEKDPE
uniprot
proteins
function
FUNCTION: Associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (By similarity) (PubMed:10506124). Has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (By similarity). Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine (By similarity). Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules (By similarity). {ECO:0000250|UniProtKB:P82251, ECO:0000269|PubMed:10506124}.
uniprot
proteins
mass_dalton
53658
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
pubmed
10506124
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16358225
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
487
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:10506124, ECO:0000269|PubMed:16358225}; Multi-pass membrane protein {ECO:0000305|PubMed:10506124, ECO:0000305|PubMed:16358225}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..55; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 63..84; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 111..137; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 148..169; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 170..193; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 218..238; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 252..274; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 303..325; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 352..370; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 371..391; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 411..431; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 435..450; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251
uniprot
proteins