Psmb6
entrez
29666
canonical
uniprot
P28073
canonical
ensembl
ENSRNOG00000019551
resolver
ensembl
ENSRNOG00055032900
resolver
ensembl
ENSRNOG00060020772
resolver
ensembl
ENSRNOG00065028399
resolver
ensp
ENSRNOP00000026507
resolver
ensp
ENSRNOP00055047017
resolver
ensp
ENSRNOP00060029592
resolver
ensp
ENSRNOP00065040104
resolver
enst
ENSRNOT00000026507
resolver
enst
ENSRNOT00055056918
resolver
enst
ENSRNOT00060035962
resolver
enst
ENSRNOT00065048914
resolver
genesymbol
Psmb6
resolver
genesymbol_syn
Psmb6l
resolver
uniprot
Q6IE68
resolver
uniprot
Q6PDW5
resolver
uniprot_entry
PSB6_RAT
resolver
uniprot_sec
Q6IE68
resolver
uniprot_sec
Q6PDW5
resolver
amino_acid_sequence
MAAALAVRGAVSAPAFGPEALTPDWENREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKDECLQFTANALALAMERDGSSGGVIRLAAIQQSGVERQVLLGDQIPKVTISTLPPP
uniprot
proteins
ec_number
3.4.25.1
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolyzing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues. {ECO:0000250|UniProtKB:P28072}.
uniprot
proteins
mass_dalton
25290
uniprot
proteins
protein_family
Peptidase T1B family
uniprot
proteins
pubmed
1491007
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15060002
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2335214
uniprot
proteins
sequence_length
238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P28072}. Nucleus {ECO:0000250|UniProtKB:P28072}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000250|UniProtKB:P28072}.
uniprot
proteins