CASTOR2
entrez
729438
canonical
uniprot
A6NHX0
canonical
ensembl
ENSG00000274070
resolver
ensp
ENSP00000484732
resolver
enst
ENST00000616305
resolver
genesymbol
CASTOR2
resolver
genesymbol_syn
GATSL1
resolver
genesymbol_syn
GATSL2
resolver
hgnc
HGNC:37073
resolver
uniprot
A6NNH0
resolver
uniprot
B9EJH9
resolver
uniprot_entry
CAST2_HUMAN
resolver
uniprot_sec
A6NNH0
resolver
uniprot_sec
B9EJH9
resolver
amino_acid_sequence
MELHILEHRLQVASVAKESIPLFTYGLIKLAFLSSKTRCKFFSLTETPEDYTIIVDEEGFLELPSSEHLSVADATWLALNVVSGGGSFSSSQPIGVTKIAKSVIAPLADQNISVFMLSTYQTDFILVRERDLPFVTHTLSSEFTILRVVNGETVAAENLGITNGFVKPKLVQRPVIHPLSSPSNRFCVTSLDPDTLPAVATLLMDVMFYSNGVKDPMATGDDCGHIRFFSFSLIEGYISLVMDVQTQQRFPSNLLFTSASGELWKMVRIGGQPLGFDECGIVAQISEPLAAADIPAYYISTFKFDHALVPEENINGVISALKVSQAEKH
uniprot
proteins
function
FUNCTION: Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. {ECO:0000269|PubMed:26972053}.
uniprot
proteins
mass_dalton
36056
uniprot
proteins
protein_family
GATS family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26972053
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:26972053}.
uniprot
proteins