Gtf2h2
entrez
23894
canonical
uniprot
Q9JIB4
canonical
ensembl
ENSMUSG00000021639
resolver
ensp
ENSMUSP00000065228
resolver
ensp
ENSMUSP00000225266
resolver
ensp
ENSMUSP00000225271
resolver
enst
ENSMUST00000066984
resolver
genesymbol
Gtf2h2
resolver
genesymbol_syn
Btf2p44
resolver
uniprot
Q7TPV0
resolver
uniprot_entry
Q7TPV0_MOUSE
resolver
uniprot_entry
TF2H2_MOUSE
resolver
amino_acid_sequence
MDEEPERTKRWEGGYERTWEILKEDETGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKKAVDMTCHGEPSLYNSLSMAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKTLKTAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDETHYKELLAHHVSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDNNSTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEISLEEYKGERFCYGCQGELKDQHVYVCTVCQNVFCVDCDVFVHDSLHCCPGCIHKIPTPSGI
uniprot
proteins
function
FUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. {ECO:0000250|UniProtKB:Q13888}.
uniprot
proteins
mass_dalton
44687
uniprot
proteins
protein_family
GTF2H2 family
uniprot
proteins
pubmed
10958627
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13888}.
uniprot
proteins