Psmd10
entrez
116722
canonical
uniprot
Q9Z2X3
canonical
ensembl
ENSRNOG00000051669
resolver
ensp
ENSRNOP00000071909
resolver
ensp
ENSRNOP00000082840
resolver
enst
ENSRNOT00000086698
resolver
enst
ENSRNOT00000106019
resolver
genesymbol
Psmd10
resolver
genesymbol_syn
AABR07040855.1
resolver
uniprot
A0A8I5ZXW8
resolver
uniprot
A0ACM8QF25
resolver
uniprot
A6HLQ9
resolver
uniprot
B0BMV9
resolver
uniprot_entry
A0A8I5ZXW8_RAT
resolver
uniprot_entry
A0ACM8QF25_RAT
resolver
uniprot_entry
A6HLQ9_RAT
resolver
uniprot_entry
PSD10_RAT
resolver
uniprot_sec
B0BMV9
resolver
amino_acid_sequence
MEGCVSNLMVCNLAYNGKLDELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNEKDDAGWSPLHIAASAGRDEIVKALLIKGAQVNAVNQNGCTALHYAASKNRHEIAVMLLEGGANPDAKNHYDATAMHRAAAKGNLKMVHILLFYKASTNIQDTEGNTPLHLACDEERVEEAKLLVTQGASIYIENKEEKTPLQVAKGGLGLILKRIAESEEASM
uniprot
proteins
function
FUNCTION: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module (By similarity). Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis (By similarity). {ECO:0000250}.; FUNCTION: Acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
24985
uniprot
proteins
sequence_length
231
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins