Dram2
entrez
67171
canonical
uniprot
Q9CR48
canonical
ensembl
ENSMUSG00000027900
resolver
ensp
ENSMUSP00000029507
resolver
ensp
ENSMUSP00000063510
resolver
ensp
ENSMUSP00000112680
resolver
ensp
ENSMUSP00000194795
resolver
ensp
ENSMUSP00000194805
resolver
ensp
ENSMUSP00000194821
resolver
ensp
ENSMUSP00000194823
resolver
ensp
ENSMUSP00000327970
resolver
enst
ENSMUST00000029507
resolver
enst
ENSMUST00000067630
resolver
enst
ENSMUST00000121034
resolver
genesymbol
Dram2
resolver
genesymbol_syn
Tmem77
resolver
uniprot
F8WI45
resolver
uniprot
Q9D520
resolver
uniprot
Q9D835
resolver
uniprot_entry
DRAM2_MOUSE
resolver
uniprot_entry
F8WI45_MOUSE
resolver
uniprot_entry
Q9D835_MOUSE
resolver
uniprot_sec
Q9D520
resolver
amino_acid_sequence
MWWFQQGLSFLPSALVIWTFATFIFSYITAITLHHVDPALPYISDTGTIPPERCLFGVMLNIAAVLGIATMYVRYKQVHALNPEENLIIKLNKAGLVLGILSCLGLSLVANFQKSTLFIVHVCGAVLAFSMGSFYMFVQTILSYQMQPKIHSKQVFWVRLLLVIWCGVSALSMMTCSSILYSSDFGPDVVQKLHWNPEDKGYVLHLVTTAAEWSMSFSFFGFFLTYIRDFQKITLRVEANLHGLTLYDTVPCPVNNERTPLLSRDFQ
uniprot
proteins
function
FUNCTION: Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1. {ECO:0000250|UniProtKB:Q6UX65}.
uniprot
proteins
mass_dalton
30228
uniprot
proteins
protein_family
DRAM/TMEM150 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
25983245
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q6UX65}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6UX65}. Photoreceptor inner segment {ECO:0000269|PubMed:25983245}. Apical cell membrane {ECO:0000269|PubMed:25983245}. Note=Localized to photoreceptor inner segments and to the apical surface of retinal pigment epithelial cells. {ECO:0000269|PubMed:25983245}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins