PRLR
entrez
5618
canonical
uniprot
P16471
canonical
ensembl
ENSG00000113494
resolver
ensp
ENSP00000422935
resolver
ensp
ENSP00000425300
resolver
ensp
ENSP00000441813
resolver
ensp
ENSP00000482689
resolver
ensp
ENSP00000482954
resolver
ensp
ENSP00000484768
resolver
ensp
ENSP00000522429
resolver
ensp
ENSP00000522430
resolver
ensp
ENSP00000522431
resolver
genesymbol
PRLR
resolver
hgnc
HGNC:9446
resolver
uniprot
B2R882
resolver
uniprot
D1MDP1
resolver
uniprot
Q16354
resolver
uniprot
Q8TD75
resolver
uniprot
Q8TD78
resolver
uniprot
Q96P35
resolver
uniprot
Q96P36
resolver
uniprot
Q9BX87
resolver
uniprot
Q9UHJ5
resolver
uniprot_entry
PRLR_HUMAN
resolver
uniprot_sec
B2R882
resolver
uniprot_sec
D1MDP1
resolver
uniprot_sec
Q16354
resolver
uniprot_sec
Q8TD75
resolver
uniprot_sec
Q8TD78
resolver
uniprot_sec
Q96P35
resolver
uniprot_sec
Q96P36
resolver
uniprot_sec
Q9BX87
resolver
uniprot_sec
Q9UHJ5
resolver
amino_acid_sequence
MKENVASATVFTLLLFLNTCLLNGQLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDTTVWISVAVLSAVICLIIVWAVALKGYSMVTCIFPPVPGPKIKGFDAHLLEKGKSEELLSALGCQDFPPTSDYEDLLVEYLEVDDSEDQHLMSVHSKEHPSQGMKPTYLDPDTDSGRGSCDSPSLLSEKCEEPQANPSTFYDPEVIEKPENPETTHTWDPQCISMEGKIPYFHAGGSKCSTWPLPQPSQHNPRSSYHNITDVCELAVGPAGAPATLLNEAGKDALKSSQTIKSREEGKATQQREVESFHSETDQDTPWLLPQEKTPFGSAKPLDYVEIHKVNKDGALSLLPKQRENSGKPKKPGTPENNKEYAKVSGVMDNNILVLVPDPHAKNVACFEESAKEAPPSLEQNQAEKALANFTATSSKCRLQLGGLDYLDPACFTHSFH
uniprot
proteins
disease_involvement
DISEASE: Multiple fibroadenomas of the breast (MFAB) [MIM:615554]: A benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue. {ECO:0000269|PubMed:18779591}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Hyperprolactinemia (HPRL) [MIM:615555]: A disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea. {ECO:0000269|PubMed:24195502}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. {ECO:0000269|PubMed:12580759, ECO:0000269|PubMed:20032052}.
uniprot
proteins
mass_dalton
69506
uniprot
proteins
protein_family
Type 1 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
10084611
uniprot
proteins
pubmed
10585417
uniprot
proteins
pubmed
11518703
uniprot
proteins
pubmed
12351696
uniprot
proteins
pubmed
12580759
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15618286
uniprot
proteins
pubmed
16546209
uniprot
proteins
pubmed
16740656
uniprot
proteins
pubmed
18467331
uniprot
proteins
pubmed
18779591
uniprot
proteins
pubmed
20032052
uniprot
proteins
pubmed
24195502
uniprot
proteins
pubmed
2558309
uniprot
proteins
pubmed
7768908
uniprot
proteins
pubmed
7984244
uniprot
proteins
sequence_length
622
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}; Single-pass type I membrane protein {ECO:0000269|PubMed:11518703, ECO:0000269|PubMed:12580759}.; SUBCELLULAR LOCATION: [Isoform 7]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 235..258; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins