Gabrr1
entrez
14408
canonical
uniprot
P56475
canonical
ensembl
ENSMUSG00000028280
resolver
ensp
ENSMUSP00000029947
resolver
enst
ENSMUST00000029947
resolver
genesymbol
Gabrr1
resolver
uniprot
A3KG51
resolver
uniprot_entry
GBRR1_MOUSE
resolver
uniprot_sec
A3KG51
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by TPMPA, a rho-specific antagonist, when forming a homopentamer (PubMed:25422464). In contrast with other GABAARs, rho-1 GABAAR is not inhibited by bicuculline when forming a homopentamer (PubMed:25422464). {ECO:0000269|PubMed:25422464}.
uniprot
proteins
amino_acid_sequence
MLAVQNMKFGIFLLWWGWVLAAESTAHWPGREVHEPSRKGSRPQRQRRGAHDDAHKQGSPILRRSSDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSSNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKISCTCGLPQPRGVMLDSSYSDGEVNDLGGYMPENGEKPDRMMVQLTLASERGSPQRKGQRGSYVSMRINTHAIDKYSRIIFPAAYILFNLIYWSIFS
uniprot
proteins
function
FUNCTION: Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain. Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces. When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Rho-1 subunits are primarily expressed in retina where rho-1-containing GABAARs play a role in retinal neurotransmission (By similarity). Rho-1 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (PubMed:16945976). Rho-1 GABAARs may also contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (PubMed:25422464). {ECO:0000250|UniProtKB:P24046, ECO:0000269|PubMed:16945976, ECO:0000269|PubMed:25422464}.
uniprot
proteins
mass_dalton
55488
uniprot
proteins
protein_family
GABRR1 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
16945976
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25422464
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:16945976}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P24046}. Cell membrane {ECO:0000269|PubMed:25422464}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P24046}. Note=Located at the plasma membrane of astrocytes (PubMed:25422464). Located in the plasma membrane of glial cell processes (PubMed:25422464). {ECO:0000269|PubMed:25422464}.
uniprot
proteins
transmembrane_region
TRANSMEM 282..302; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 315..335; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 347..367; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 459..479; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins