MAP6
entrez
4135
canonical
uniprot
Q96JE9
canonical
ensembl
ENSG00000171533
resolver
ensp
ENSP00000307093
resolver
ensp
ENSP00000415108
resolver
ensp
ENSP00000434278
resolver
ensp
ENSP00000710576
resolver
genesymbol
MAP6
resolver
genesymbol_syn
KIAA1878
resolver
hgnc
HGNC:6868
resolver
uniprot
A7E2A1
resolver
uniprot
Q6P3T0
resolver
uniprot
Q6ZWB8
resolver
uniprot_entry
MAP6_HUMAN
resolver
uniprot_sec
A7E2A1
resolver
uniprot_sec
Q6P3T0
resolver
uniprot_sec
Q6ZWB8
resolver
amino_acid_sequence
MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAKESLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQDHTVPEPLKNESPVISAPVKDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVPAPVKDEGPMVSASVKDQGPMVSAPVKDQGPIVPAPVKGEGPIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEPVKNQGLVVSGPVKDQDVVVPEHAKVHDSAVVAPVKNQGPVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLKDQDPLVPVPAKDQGPAVPEPLKTQGPRDPQLPTVSPLPRVMIPTAPHTEYIESSP
uniprot
proteins
function
FUNCTION: Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity). {ECO:0000250|UniProtKB:Q63560, ECO:0000269|PubMed:24357581}.
uniprot
proteins
mass_dalton
86505
uniprot
proteins
mutagenesis
MUTAGEN 71; /note="P->A: Inhibits interaction with ZDHHC13 and ZDHHC17."; /evidence="ECO:0000269|PubMed:26198635
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Probably depalmitoylated by ABHD17A, ABHD17B and ABHD17C. During neuronal polarization, palmitoylation and depalmitoylation cycles regulate MAP6 shuttling between secretory vesicles and microtubules, and its polarized distribution in the axon. {ECO:0000250|UniProtKB:Q63560}.
uniprot
proteins
protein_family
STOP family
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
14692697
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16624526
uniprot
proteins
pubmed
24357581
uniprot
proteins
pubmed
26198635
uniprot
proteins
sequence_length
813
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14692697}. Golgi apparatus {ECO:0000250|UniProtKB:Q63560}. Cell projection, axon {ECO:0000250|UniProtKB:Q63560}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63560}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q63560}; Lipid-anchor {ECO:0000250|UniProtKB:Q63560}; Cytoplasmic side {ECO:0000250|UniProtKB:Q63560}. Note=Localizes predominantly in the proximal part of the axon (By similarity). Preferentially is concentrated on a portion of the microtubule polymer in which tubulin is modified by detyrosination and acetylation and is also resistant to depolymerization induced by both nocodazole and cold (By similarity). In unpolarized neurons, localizes to the Golgi and to secretory vesicles accumulating transiently at the tips of a subset of neurites (By similarity). Following neuronal polarization and during axon outgrowth, accumulates in the axonal growth cone and subsequently localizes throughout the axon (By similarity). Partially localizes to dendrites in mature neurons (By similarity). Colocalizes with neurofilament (NF)-rich inclusions in spinal cord and brain neurons of patients with amyotrophic lateral sclerosis (ALS) (PubMed:14692697). {ECO:0000250|UniProtKB:Q63560, ECO:0000269|PubMed:14692697}.
uniprot
proteins