Tsku
entrez
244152
canonical
uniprot
Q8CBR6
canonical
ensembl
ENSMUSG00000049580
resolver
ensp
ENSMUSP00000091713
resolver
ensp
ENSMUSP00000127242
resolver
ensp
ENSMUSP00000128431
resolver
ensp
ENSMUSP00000130917
resolver
ensp
ENSMUSP00000131789
resolver
ensp
ENSMUSP00000137437
resolver
ensp
ENSMUSP00000146025
resolver
ensp
ENSMUSP00000193576
resolver
ensp
ENSMUSP00000193577
resolver
enst
ENSMUST00000094161
resolver
enst
ENSMUST00000164726
resolver
enst
ENSMUST00000165257
resolver
enst
ENSMUST00000165901
resolver
enst
ENSMUST00000167405
resolver
enst
ENSMUST00000179780
resolver
enst
ENSMUST00000206414
resolver
genesymbol
Tsku
resolver
genesymbol_syn
Lrrc54
resolver
genesymbol_syn
Tsk
resolver
uniprot
Q08EE6
resolver
uniprot
Q4W655
resolver
uniprot_entry
Q08EE6_MOUSE
resolver
uniprot_entry
TSK_MOUSE
resolver
uniprot_sec
Q4W655
resolver
amino_acid_sequence
MLCSLFLLLLAVGRVQTTRPCFPGCQCEEETFGLFDSFSLIRVDCSSLGPHIVPVPIPLDTAHLDLSSNRLETVNESVLAGPGYTTLAGLDLSYNLLTSIMPSAFSRLRYLESLDLSHNGLAALPAEIFTSSPLSDINLSHNRLREVSISAFTTHSQGRALHVDLSHNLIHRLLPHPARASLPAPTIQSLNLSWNRFRAVPDLRDLPLRYLSLDGNPLATINPDAFMGLAGLTHLSLASLQGILHLPPHGFRELPGLQVLDLSGNPKLKWAGAEVFSGLGLLQELDLSGSSLVPLPEMLLHHLPALQSVSVGQDVQCRRLVREGAYHRQPGSSPKVVLHCGDTQESAARGPDIL
uniprot
proteins
function
FUNCTION: Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways (PubMed:21856951, PubMed:22995554, PubMed:25159578, PubMed:31391339). Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye (PubMed:21856951). Plays a role in regulating the hair cycle by controlling TGFB1 signaling (PubMed:22995554). Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth (PubMed:21055390, PubMed:23206892). Essential for terminal differentiation of hippocampal neural stem cells (PubMed:31983064). Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size (PubMed:30271858). Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells (PubMed:32127020). Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence (PubMed:25159578). Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver (PubMed:31391339). In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure (PubMed:31535079). In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis (PubMed:31767170). {ECO:0000269|PubMed:21055390, ECO:0000269|PubMed:21856951, ECO:0000269|PubMed:22995554, ECO:0000269|PubMed:23206892, ECO:0000269|PubMed:25159578, ECO:0000269|PubMed:30271858, ECO:0000269|PubMed:31391339, ECO:0000269|PubMed:31535079, ECO:0000269|PubMed:31767170, ECO:0000269|PubMed:31983064, ECO:0000269|PubMed:32127020}.
uniprot
proteins
mass_dalton
38362
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21055390
uniprot
proteins
pubmed
21856951
uniprot
proteins
pubmed
22995554
uniprot
proteins
pubmed
23206892
uniprot
proteins
pubmed
25159578
uniprot
proteins
pubmed
30232710
uniprot
proteins
pubmed
30271858
uniprot
proteins
pubmed
30595550
uniprot
proteins
pubmed
31391339
uniprot
proteins
pubmed
31535079
uniprot
proteins
pubmed
31767170
uniprot
proteins
pubmed
31983064
uniprot
proteins
pubmed
32127020
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30595550, ECO:0000269|PubMed:31391339, ECO:0000269|PubMed:31535079, ECO:0000269|PubMed:31767170}.
uniprot
proteins