LRR1
entrez
122769
canonical
uniprot
Q96L50
canonical
ensembl
ENSG00000165501
resolver
ensp
ENSP00000298288
resolver
ensp
ENSP00000315628
resolver
genesymbol
LRR1
resolver
genesymbol_syn
PPIL5
resolver
hgnc
HGNC:19742
resolver
uniprot
A0A384MTQ0
resolver
uniprot
A5D6X3
resolver
uniprot
B4DDE0
resolver
uniprot
Q52M24
resolver
uniprot
Q86SZ1
resolver
uniprot
Q8N6H9
resolver
uniprot_entry
A0A384MTQ0_HUMAN
resolver
uniprot_entry
LLR1_HUMAN
resolver
uniprot_sec
A5D6X3
resolver
uniprot_sec
B4DDE0
resolver
uniprot_sec
Q52M24
resolver
uniprot_sec
Q86SZ1
resolver
uniprot_sec
Q8N6H9
resolver
amino_acid_sequence
MKLHCEVEVISRHLPALGLRNRGKGVRAVLSLCQQTSRSQPPVRAFLLISTLKDKRGTRYELRENIEQFFTKFVDEGKATVRLKEPPVDICLSKAISSSLKGFLSAMRLAHRGCNVDTPVSTLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDLFGNTFEQPKVLPVIKLQAPLTLLESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCGRFCLNSFIQGTTTMNLHSVAHTVVLVDNLGGTEAPIISYFCSLGCYVNSSDMLK
uniprot
proteins
function
FUNCTION: Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1 (PubMed:11804328). {ECO:0000250|UniProtKB:D3YY91, ECO:0000269|PubMed:11804328, ECO:0000269|PubMed:15601820}.
uniprot
proteins
mass_dalton
46723
uniprot
proteins
mutagenesis
MUTAGEN 341..344; /note="HIIP->AAA: Abolishes interaction with CUL2 and RBX1."; /evidence="ECO:0000269|PubMed:15601820
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:15601820}.
uniprot
proteins
pubmed
11804328
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15601820
uniprot
proteins
pubmed
34700328
uniprot
proteins
sequence_length
414
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34700328}.
uniprot
proteins