Sult2a1
entrez
20859
canonical
uniprot
P52843
canonical
ensembl
ENSMUSG00000078798
resolver
ensp
ENSMUSP00000104162
resolver
enst
ENSMUST00000108522
resolver
genesymbol
Sult2a1
resolver
genesymbol_syn
Sta1
resolver
uniprot_entry
ST2A1_MOUSE
resolver
amino_acid_sequence
MMSDYNWFEGIPFPAISYQREILEDIRNKFVVKEEDLLILTYPKSGTNWLIEIVCLIQTKGDPKWIQTVPIWNRSPWIETDIGYSALINKEGPRLITSHLPIHLFSKSFFSSKAKAIYLVRNPRDILVSGYFFWGNTNLVKNPGSLGTYFEWFLKGNVLFGSWFEHVRGWLSMREWDNFLVLYYEDIKKDTKGTIKKICDFLGKNLGPDELDLVLKYSSFQAMKENNMSNFSLIKEDQVTNGLKLMRKGTIGDWKNHFTVAQAEAFDKVFQEKMAGFPPGIFPWE
uniprot
proteins
ec_number
2.8.2.14
uniprot
proteins
ec_number
2.8.2.2
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed:12639899). Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism (By similarity). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity). {ECO:0000250|UniProtKB:P15709, ECO:0000250|UniProtKB:Q06520, ECO:0000269|PubMed:12639899}.
uniprot
proteins
mass_dalton
33213
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
12639899
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8483851
uniprot
proteins
sequence_length
285
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q06520}.
uniprot
proteins