Arel1
entrez
68497
canonical
uniprot
Q8CHG5
canonical
ensembl
ENSMUSG00000042350
resolver
ensp
ENSMUSP00000048780
resolver
ensp
ENSMUSP00000271195
resolver
ensp
ENSMUSP00000271197
resolver
ensp
ENSMUSP00000271200
resolver
ensp
ENSMUSP00000271215
resolver
ensp
ENSMUSP00000271217
resolver
enst
ENSMUST00000043169
resolver
genesymbol
Arel1
resolver
genesymbol_syn
Kiaa0317
resolver
uniprot
Q6P9Q1
resolver
uniprot
Q80YC4
resolver
uniprot
Q8C5W5
resolver
uniprot_entry
AREL1_MOUSE
resolver
uniprot_sec
Q6P9Q1
resolver
uniprot_sec
Q80YC4
resolver
uniprot_sec
Q8C5W5
resolver
amino_acid_sequence
MFYVIGGIIVSVVAFFFTIKFLFELAARVVSFLQNEDRERRGDRTIYDYVRGNYLDPRSCKVSWDWKDPYEVGHSMAFRVHLFYKNGQPFPAHRPVGLRVHISHVELAVDIPVTQEVLQEPNSNVVKVAFTVRKAGRYEITVKLGGLNVAYSPYYKIFQPGMVVPSKTKIVCHFSTLVLTCGQPHTLQIVPRDEYDNPTNNSMSLRDEHSYSLAIHELGPQEEENNEVSFEKSVTSNRQTCQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVLSENEKNIVERNVSTSGVSIYFEAYLYNANNCTSTPWHLPPMHMSSSQRRPSTAIEEDDEDSPSECHTPEKVKKPKKVYCYVSPKQFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTSQLFARFTDSNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEMELVFAEEKYNKSGQLDKIVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDINVSDFKAHAVVVGGSWHFREKVMRWFWAVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGML
uniprot
proteins
ec_number
2.3.2.26
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages (By similarity). E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro (By similarity). Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome (PubMed:31578312). {ECO:0000250|UniProtKB:O15033, ECO:0000269|PubMed:31578312}.
uniprot
proteins
mass_dalton
94199
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:O15033}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated in vitro in the presence of E2 enzyme UBE2D1/UBCH5A. {ECO:0000250|UniProtKB:O15033}.
uniprot
proteins
pubmed
12465718
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23479728
uniprot
proteins
pubmed
31578312
uniprot
proteins
sequence_length
823
uniprot
proteins