TBXA2R
entrez
6915
canonical
uniprot
P21731
canonical
ensembl
ENSG00000006638
resolver
ensp
ENSP00000364336
resolver
ensp
ENSP00000393333
resolver
ensp
ENSP00000552366
resolver
genesymbol
TBXA2R
resolver
hgnc
HGNC:11608
resolver
uniprot
O75228
resolver
uniprot
Q05C92
resolver
uniprot
Q0VAB0
resolver
uniprot
Q6DK52
resolver
uniprot
Q9UCY1
resolver
uniprot
Q9UCY2
resolver
uniprot_entry
Q05C92_HUMAN
resolver
uniprot_entry
Q0VAB0_HUMAN
resolver
uniprot_entry
TA2R_HUMAN
resolver
uniprot_sec
O75228
resolver
uniprot_sec
Q6DK52
resolver
uniprot_sec
Q9UCY1
resolver
uniprot_sec
Q9UCY2
resolver
amino_acid_sequence
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
uniprot
proteins
disease_involvement
DISEASE: Bleeding disorder, platelet-type, 13 (BDPLT13) [MIM:614009]: A disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding. {ECO:0000269|PubMed:7929844, ECO:0000269|PubMed:8613548}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. {ECO:0000269|PubMed:8613548}.; FUNCTION: [Isoform 1]: Activates adenylyl cyclase. {ECO:0000269|PubMed:8613548}.; FUNCTION: [Isoform 2]: Inhibits adenylyl cyclase. {ECO:0000269|PubMed:8613548}.
uniprot
proteins
mass_dalton
37431
uniprot
proteins
mutagenesis
MUTAGEN 291; /note="L->R: Suppresses antagonist binding."; /evidence="ECO:0000269|PubMed:8246916"; MUTAGEN 295; /note="R->Q: Reduces antagonist binding."; /evidence="ECO:0000269|PubMed:8246916"; MUTAGEN 299; /note="W->L: Reduces antagonist binding."; /evidence="ECO:0000269|PubMed:8246916"; MUTAGEN 299; /note="W->R: Reduces antagonist binding."; /evidence="ECO:0000269|PubMed:8246916
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17499743
uniprot
proteins
pubmed
18088317
uniprot
proteins
pubmed
1825698
uniprot
proteins
pubmed
19464661
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7896853
uniprot
proteins
pubmed
7929844
uniprot
proteins
pubmed
7965765
uniprot
proteins
pubmed
8034687
uniprot
proteins
pubmed
8227091
uniprot
proteins
pubmed
8246916
uniprot
proteins
pubmed
8613548
uniprot
proteins
sequence_length
343
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 30..52; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 67..87; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 107..128; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 150..172; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 194..219; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 247..270; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 290..311; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins