P4HA1
entrez
5033
canonical
uniprot
P13674
canonical
ensembl
ENSG00000122884
resolver
ensp
ENSP00000263556
resolver
ensp
ENSP00000378353
resolver
ensp
ENSP00000414464
resolver
ensp
ENSP00000556259
resolver
genesymbol
P4HA1
resolver
genesymbol_syn
P4HA
resolver
hgnc
HGNC:8546
resolver
uniprot
C9JL12
resolver
uniprot
Q15082
resolver
uniprot
Q15083
resolver
uniprot
Q5VSQ5
resolver
uniprot
Q5VSQ6
resolver
uniprot_entry
P4HA1_HUMAN
resolver
uniprot_entry
Q5VSQ6_HUMAN
resolver
uniprot_sec
C9JL12
resolver
uniprot_sec
Q15082
resolver
uniprot_sec
Q15083
resolver
uniprot_sec
Q5VSQ5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by poly(L-proline). {ECO:0000269|PubMed:9211872}.
uniprot
proteins
amino_acid_sequence
MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQYFPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLRRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE
uniprot
proteins
ec_number
1.14.11.2
uniprot
proteins
function
FUNCTION: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. {ECO:0000269|PubMed:9211872}.
uniprot
proteins
mass_dalton
61049
uniprot
proteins
mutagenesis
MUTAGEN 210; /note="Y->A: Strongly reduced affinity for peptide substrate."; /evidence="ECO:0000269|PubMed:15456751"; MUTAGEN 213; /note="Y->A: Strongly reduced affinity for peptide substrate."; /evidence="ECO:0000269|PubMed:15456751"; MUTAGEN 247; /note="Y->A: Strongly reduced affinity for peptide substrate."; /evidence="ECO:0000269|PubMed:15456751
uniprot
proteins
protein_family
P4HA family
uniprot
proteins
pubmed
15028279
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15456751
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2543975
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7961714
uniprot
proteins
pubmed
9211872
uniprot
proteins
sequence_length
534
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.
uniprot
proteins