KCNN1
entrez
3780
canonical
uniprot
Q92952
canonical
ensembl
ENSG00000105642
resolver
ensp
ENSP00000476519
resolver
ensp
ENSP00000484926
resolver
ensp
ENSP00000506918
resolver
ensp
ENSP00000507021
resolver
ensp
ENSP00000507047
resolver
ensp
ENSP00000507255
resolver
ensp
ENSP00000507977
resolver
ensp
ENSP00000595868
resolver
ensp
ENSP00000595869
resolver
ensp
ENSP00000595870
resolver
ensp
ENSP00000595871
resolver
ensp
ENSP00000595872
resolver
enst
ENST00000682421
resolver
enst
ENST00000682733
resolver
enst
ENST00000683588
resolver
enst
ENST00000684725
resolver
enst
ENST00000925809
resolver
enst
ENST00000925810
resolver
enst
ENST00000925811
resolver
enst
ENST00000925812
resolver
enst
ENST00000925813
resolver
genesymbol
KCNN1
resolver
genesymbol_syn
SK
resolver
hgnc
HGNC:6290
resolver
uniprot
A0A804HIF9
resolver
uniprot
A0A804HIW7
resolver
uniprot
Q5KR10
resolver
uniprot
Q6DJU4
resolver
uniprot_entry
A0A804HIF9_HUMAN
resolver
uniprot_entry
A0A804HIW7_HUMAN
resolver
uniprot_entry
KCNN1_HUMAN
resolver
uniprot_sec
Q5KR10
resolver
uniprot_sec
Q6DJU4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by bee venom neurotoxin apamin (PubMed:17142458, PubMed:9287325). Inhibited by d-tubocurarine and tetraethylammonium (TEA) (PubMed:17142458, PubMed:9287325). {ECO:0000269|PubMed:17142458, ECO:0000269|PubMed:9287325}.
uniprot
proteins
amino_acid_sequence
MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPRGQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYLLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARVRKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG
uniprot
proteins
function
FUNCTION: Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:17142458, PubMed:8781233, PubMed:9287325). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:8781233). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (Probable). Activation is followed by membrane hyperpolarization (By similarity). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity). {ECO:0000250|UniProtKB:Q9EQR3, ECO:0000269|PubMed:17142458, ECO:0000269|PubMed:8781233, ECO:0000269|PubMed:9287325, ECO:0000305|PubMed:9287325}.
uniprot
proteins
mass_dalton
59987
uniprot
proteins
mutagenesis
MUTAGEN 216; /note="T->S: Significantly increased inhibition by apamin (IC(50)=167 pM). No effect on inhibition by d-tubocurarine and tetraethylammonium (TEA). Significant increase in inhibition by apamin (IC(50)=26 pM); when associated with Q-310, D-312 and N-339."; /evidence="ECO:0000269|PubMed:17142458"; MUTAGEN 310; /note="K->Q: Loss of inhibition by apamin. No effect on inhibition by d-tubocurarine. Increased inhibition by apamin; when associated with D-312. Significant increase in inhibition by apamin (IC(50)=366 pM); when associated with D-312 and N-339. Significant increase in inhibition by apamin (IC(50)=26 pM); when associated with S-216, D-312 and N-339."; /evidence="ECO:0000269|PubMed:17142458, ECO:0000269|PubMed:9287325"; MUTAGEN 312; /note="E->D: Increased inhibition by apamin or d-tubocurarine (IC(50)=62.6 uM). Additive increase in inhibition by apamin or d-tubocurarine (IC(50)=6.3 uM); when associated with N-339. Additive increase in inhibition by apamin; when associated with Q-310. Significant increase in inhibition by apamin (IC(50)=366 pM); when associated with Q-310 and N-339. Significant increase in inhibition by apamin (IC(50)=26 pM); when associated with S-216, Q-310 and N-339."; /evidence="ECO:0000269|PubMed:17142458, ECO:0000269|PubMed:9287325"; MUTAGEN 332..334; /note="GYG->AAA: Impairs small conductance calcium-activated potassium channel activity of KCNN2."; /evidence="ECO:0000269|PubMed:20689065"; MUTAGEN 337; /note="V->Y: Increased inhibition by tetraethylammonium (TEA)."; /evidence="ECO:0000269|PubMed:9287325"; MUTAGEN 339; /note="H->N: Increased inhibition by apamin or d-tubocurarine (IC(50)=11.1 uM). Additive increase in inhibition by apamin or d-tubocurarine (IC(50)=6.3 uM); when associated with D-312. Significant increase in inhibition by apamin (IC(50)=366 pM); when associated with Q-310 and D-312. Significant increase in inhibition by apamin (IC(50)=26 pM); when associated with S-216, Q-310 and D-312."; /evidence="ECO:0000269|PubMed:17142458, ECO:0000269|PubMed:9287325
uniprot
proteins
protein_family
KCa2.1/KCNN1 subfamily
uniprot
proteins
protein_family
Potassium channel KCNN family
uniprot
proteins
pubmed
10516439
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17142458
uniprot
proteins
pubmed
20689065
uniprot
proteins
pubmed
8781233
uniprot
proteins
pubmed
9287325
uniprot
proteins
sequence_length
543
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q9EQR3}.
uniprot
proteins
transmembrane_region
TRANSMEM 111..131; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 228..248; /note="Helical; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 346..366; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins