INCA1
entrez
388324
canonical
uniprot
Q0VD86
canonical
ensembl
ENSG00000196388
resolver
ensp
ENSP00000347129
resolver
ensp
ENSP00000458316
resolver
ensp
ENSP00000460673
resolver
ensp
ENSP00000461844
resolver
ensp
ENSP00000511805
resolver
ensp
ENSP00000565078
resolver
ensp
ENSP00000565079
resolver
ensp
ENSP00000565083
resolver
ensp
ENSP00000565086
resolver
genesymbol
INCA1
resolver
hgnc
HGNC:32224
resolver
uniprot
Q6J273
resolver
uniprot
Q6PKN9
resolver
uniprot_entry
INCA1_HUMAN
resolver
uniprot_sec
Q6J273
resolver
uniprot_sec
Q6PKN9
resolver
amino_acid_sequence
MQVQDDGVNLIPFAKCSRVVSRSPPPRLPSQSLRPMPQRYGDVFWKNLNQRPTPTWLEEQHIPPMLRATGCSQLGLYPPEQLPPPEMLWRRKKRRPCLEGMQQQGLGGVPARVRAVTYHLEDLRRRQSIINELKKAQWGSSGAASEPVVLGEEGCGFPSTNEYPDLEEERATYPQEEDRFLTPGRAQLLWSPWSPLDQEEACASRQLHSLASFSTVTARRNPLHNPWGMELAASEE
uniprot
proteins
function
FUNCTION: Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity). {ECO:0000250|UniProtKB:Q6PKN7, ECO:0000269|PubMed:21540187}.
uniprot
proteins
mass_dalton
26817
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="S->A: Loss of phosphorylation site."; /evidence="ECO:0000269|PubMed:15159402"; MUTAGEN 182; /note="T->A: Reduced phosphorylation. Phosphorylation is almost abolished; when associated with A-191."; /evidence="ECO:0000269|PubMed:15159402"; MUTAGEN 191; /note="S->A: Strongly reduced phosphorylation. Phosphorylation is almost abolished; when associated with A-182."; /evidence="ECO:0000269|PubMed:15159402"; MUTAGEN 194; /note="S->A: Reduced phosphorylation."; /evidence="ECO:0000269|PubMed:15159402
uniprot
proteins
post_translational_modification
PTM: Phosphorylated when part of a complex with CCNA1 and CDK2. Strongly phosphorylated by CDK2 on its C-terminal region spanning amino acid 149-221. Less intensively phosphorylated by CDK2 on its first 75 amino acid residues. {ECO:0000269|PubMed:15159402}.
uniprot
proteins
protein_family
INCA family
uniprot
proteins
pubmed
15159402
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18756329
uniprot
proteins
pubmed
21540187
uniprot
proteins
pubmed
21750715
uniprot
proteins
pubmed
21874239
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15159402, ECO:0000269|PubMed:18756329}. Cytoplasm {ECO:0000269|PubMed:18756329}.
uniprot
proteins