PLA2G4E
entrez
123745
canonical
uniprot
Q3MJ16
canonical
ensembl
ENSG00000188089
resolver
ensp
ENSP00000382434
resolver
ensp
ENSP00000512406
resolver
ensp
ENSP00000512408
resolver
ensp
ENSP00000512409
resolver
enst
ENST00000696112
resolver
enst
ENST00000696114
resolver
enst
ENST00000696115
resolver
genesymbol
PLA2G4E
resolver
hgnc
HGNC:24791
resolver
uniprot
A0A8Q3SIH7
resolver
uniprot
A0A8Q3WM91
resolver
uniprot
B7WPN2
resolver
uniprot
Q6ZSC0
resolver
uniprot_entry
A0A8Q3SIH7_HUMAN
resolver
uniprot_entry
A0A8Q3WM91_HUMAN
resolver
uniprot_entry
PA24E_HUMAN
resolver
uniprot_sec
B7WPN2
resolver
uniprot_sec
Q6ZSC0
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by cytosolic Ca(2+). Stimulated by anionic phospholipids such as phosphatidylserines, phosphatidates and phosphatidylinositols. {ECO:0000269|PubMed:29447909, ECO:0000269|PubMed:30517655}.
uniprot
proteins
amino_acid_sequence
MSLQASEGCPGLGTNVFVPQSPQTDEEGSRSGRSFSEFEDTQDLDTPGLPPFCPMAPWGSEEGLSPCHLLTVRVIRMKNVRQADMLSQTDCFVSLWLPTASQKKLRTRTISNCPNPEWNESFNFQIQSRVKNVLELSVCDEDTVTPDDHLLTVLYDLTKLCFRKKTHVKFPLNPQGMEELEVEFLLEESPSPPETLVTNGVLVSRQVSCLEVHAQSRRRRKREKMKDLLVMVNESFENTQRVRPCLEPCCPTSACFQTAACFHYPKYFQSQVHVEVPKSHWSCGLCCRSRKKGPISQPLDCLSDGQVMTLPVGESYELHMKSTPCPETLDVRLGFSLCPAELEFLQKRKVVVAKALKQVLQLEEDLQEDEVPLIAIMATGGGTRSMTSMYGHLLGLQKLNLLDCASYITGLSGATWTMATLYRDPDWSSKNLEPAIFEARRHVVKDKLPSLFPDQLRKFQEELRQRSQEGYRVTFTDFWGLLIETCLGDERNECKLSDQRAALSCGQNPLPIYLTINVKDDVSNQDFREWFEFSPYEVGLQKYGAFIPSELFGSEFFMGRLVKRIPESRICYMLGLWSSIFSLNLLDAWNLSHTSEEFFHRWTREKVQDIEDEPILPEIPKCDANILETTVVIPGSWLSNSFREILTHRSFVSEFHNFLSGLQLHTNYLQNGQFSRWKDTVLDGFPNQLTESANHLCLLDTAFFVNSSYPPLLRPERKADLIIHLNYCAGSQTKPLKQTCEYCTVQNIPFPKYELPDENENLKECYLMENPQEPDAPIVTFFPLINDTFRKYKAPGVERSPEELEQGQVDIYGPKTPYATKELTYTEATFDKLVKLSEYNILNNKDTLLQALRLAVEKKKRLKGQCPS
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Calcium-dependent N-acyltransferase involved in the biosynthesis of N-acyl ethanolamines (NAEs) in the brain (PubMed:29447909). Transfers the sn-1 fatty acyl chain of phosphatidylcholine (fatty acyl donor) to the amine group of phosphatidylethanolamine (fatty acyl acceptor) to generate N-acyl phosphatidylethanolamine (NAPE). Similarly can use plasmenylethanolamine as a fatty acyl acceptor to form N-acyl plasmenylethanolamine (N-Acyl-PlsEt). Both NAPE and N-Acyl-PlsEt can serve as precursors of bioactive NAEs like N-arachidonoyl phosphatidylethanolamine also called anandamide (PubMed:29447909, PubMed:30517655). Has weak phospholipase A2 and lysophospholipase activities (By similarity). Regulates intracellular membrane trafficking that requires modulation of membrane curvature as it occurs by enrichment in lysophospholipids. Promotes tubule formation involved in clathrin-independent endocytotic trafficking and cargo recycling (By similarity). {ECO:0000250|UniProtKB:Q50L42, ECO:0000269|PubMed:29447909, ECO:0000269|PubMed:30517655}.
uniprot
proteins
mass_dalton
99190
uniprot
proteins
mutagenesis
MUTAGEN 412; /note="S->A: Impairs localization at membrane structures and N-acyl transferase activity."; /evidence="ECO:0000269|PubMed:30517655
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
24413173
uniprot
proteins
pubmed
29447909
uniprot
proteins
pubmed
30517655
uniprot
proteins
sequence_length
868
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q50L42}. Early endosome membrane {ECO:0000250|UniProtKB:Q50L42}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q50L42}; Cytoplasmic side {ECO:0000250|UniProtKB:Q50L42}. Lysosome membrane {ECO:0000250|UniProtKB:Q50L42}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q50L42}; Cytoplasmic side {ECO:0000250|UniProtKB:Q50L42}. Cell membrane {ECO:0000250|UniProtKB:Q50L42}; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:Q50L42}. Note=Targeted to clathrin-independent endocytotic vesicles through binding to phosphoinositides, especially phosphatidylinositol 4,5-bisphosphates. {ECO:0000250|UniProtKB:Q50L42}.
uniprot
proteins