Cyth1
entrez
116691
canonical
uniprot
P97694
canonical
ensembl
ENSRNOG00000043381
resolver
ensembl
ENSRNOG00055032687
resolver
ensembl
ENSRNOG00060029546
resolver
ensembl
ENSRNOG00065004968
resolver
ensp
ENSRNOP00000004196
resolver
ensp
ENSRNOP00000093390
resolver
ensp
ENSRNOP00055046618
resolver
ensp
ENSRNOP00060042745
resolver
ensp
ENSRNOP00065005024
resolver
enst
ENSRNOT00000004196
resolver
enst
ENSRNOT00000108086
resolver
enst
ENSRNOT00055056512
resolver
enst
ENSRNOT00060051385
resolver
enst
ENSRNOT00065007247
resolver
genesymbol
Cyth1
resolver
genesymbol_syn
Pscd1
resolver
genesymbol_syn
Sec7a
resolver
genesymbol_syn
Usp36
resolver
uniprot
A0A8I6AK04
resolver
uniprot
A0ACM8QFQ0
resolver
uniprot
B2GUV0
resolver
uniprot
D4A8L6
resolver
uniprot_entry
A0A8I6AK04_RAT
resolver
uniprot_entry
A0ACM8QFQ0_RAT
resolver
uniprot_entry
B2GUV0_RAT
resolver
uniprot_entry
CYH1_RAT
resolver
uniprot_sec
D4A8L6
resolver
amino_acid_sequence
MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKVSSTKRH
uniprot
proteins
function
FUNCTION: Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. {ECO:0000250|UniProtKB:Q9QX11}.
uniprot
proteins
mass_dalton
46274
uniprot
proteins
mutagenesis
MUTAGEN 157; /note="E->K: Loss of ARF translocation."; /evidence="ECO:0000269|PubMed:9927699
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by SCF(FBXW11) E3 ubiquitin-protein ligase complex. Ubiquitination induces proteasomal degradation. {ECO:0000250|UniProtKB:Q15438}.
uniprot
proteins
pubmed
11834294
uniprot
proteins
pubmed
9352219
uniprot
proteins
pubmed
9927699
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9QX11}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9QX11}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9QX11}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9QX11}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9QX11}. Note=Colocalized with TJP1 during epithelial polarization. {ECO:0000250|UniProtKB:Q9QX11}.
uniprot
proteins