Ifi30
entrez
65972
canonical
uniprot
Q9ESY9
canonical
ensembl
ENSMUSG00000031838
resolver
ensp
ENSMUSP00000159394
resolver
enst
ENSMUST00000222087
resolver
genesymbol
Ifi30
resolver
genesymbol_syn
Gilt
resolver
genesymbol_syn
Ip30
resolver
uniprot
G3X911
resolver
uniprot
Q3U0F9
resolver
uniprot
Q9EP56
resolver
uniprot_entry
GILT_MOUSE
resolver
uniprot_sec
G3X911
resolver
uniprot_sec
Q3U0F9
resolver
uniprot_sec
Q9EP56
resolver
amino_acid_sequence
MSWSPILPFLSLLLLLFPLEVPRAATASLSQASSEGTTTCKAHDVCLLGPRPLPPSPPVRVSLYYESLCGACRYFLVRDLFPTWLMVMEIMNITLVPYGNAQERNVSGTWEFTCQHGELECRLNMVEACLLDKLEKEAAFLTIVCMEEMDDMEKKLGPCLQVYAPEVSPESIMECATGKRGTQLMHENAQLTDALHPPHEYVPWVLVNEKPLKDPSELLSIVCQLYQGTEKPDICSSIADSPRKVCYK
uniprot
proteins
ec_number
1.8.4.-
uniprot
proteins
function
FUNCTION: Lysosomal thiol reductase that catalyzes protein disulfide bonds reduction (By similarity). Plays an important role in antigen processing and presentation, of namely both major histocompatibility complex (MHC) class I- and class II-restricted antigen by reducing the disulfide bonds of endocytosed proteins and facilitating their unfolding and optimal degradation (PubMed:11701933, PubMed:20538950). Shares with thioredoxin a reduction mechanism in which the N-terminal cysteine thiol group in the CXXC active site motif initiates a nucleophilic attack on the substrate disulfide bond,resulting in the formation of a mixed disulfide-linked enzyme-substrate intermediate (Probable). Subsequent intramolecular attack by the second cysteine thiol group enables the release of the reduced substrate and oxidized enzyme (Probable). Lysosomal cysteine is a physiological reducing agent that is capable of reducing IFI30, so that it can catalyzes the next reaction (By similarity). Dithiothreitol, cysteine, and cysteinyl glycine, but not glutathione, are capable of regenerating active precursor and mature IFI30 in vitro (By similarity). {ECO:0000250|UniProtKB:P13284, ECO:0000269|PubMed:11701933, ECO:0000269|PubMed:20538950, ECO:0000305|PubMed:18815593}.
uniprot
proteins
mass_dalton
27784
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Sugar chains contain mannose-6-phosphate. {ECO:0000250|UniProtKB:P13284}.; PTM: Synthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases. {ECO:0000250|UniProtKB:P13284}.
uniprot
proteins
protein_family
GILT family
uniprot
proteins
pubmed
11701933
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18815593
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20538950
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P13284}. Lysosome {ECO:0000269|PubMed:11701933}. Note=A small amount of the precursor can be secreted outside the cell as a dimer. {ECO:0000250|UniProtKB:P13284}.
uniprot
proteins