CELA2A
entrez
63036
canonical
uniprot
P08217
canonical
ensembl
ENSG00000142615
resolver
ensp
ENSP00000352639
resolver
enst
ENST00000359621
resolver
genesymbol
CELA2A
resolver
genesymbol_syn
ELA2A
resolver
hgnc
HGNC:24609
resolver
uniprot
B2R5I4
resolver
uniprot
Q14243
resolver
uniprot_entry
CEL2A_HUMAN
resolver
uniprot_sec
B2R5I4
resolver
uniprot_sec
Q14243
resolver
amino_acid_sequence
MIRTLLLSTLVAGALSCGDPTYPPYVTRVVGGEEARPNSWPWQVSLQYSSNGKWYHTCGGSLIANSWVLTAAHCISSSRTYRVGLGRHNLYVAESGSLAVSVSKIVVHKDWNSNQISKGNDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGAVPDVLQQGRLLVVDYATCSSSAWWGSSVKTSMICAGGDGVISSCNGDSGGPLNCQASDGRWQVHGIVSFGSRLGCNYYHKPSVFTRVSNYIDWINSVIANN
uniprot
proteins
disease_involvement
DISEASE: Abdominal obesity-metabolic syndrome 4 (AOMS4) [MIM:618620]: A form of abdominal obesity-metabolic syndrome, a disorder characterized by abdominal obesity, high triglycerides, low levels of high density lipoprotein cholesterol, high blood pressure, and elevated fasting glucose levels. AOMS4 is an autosomal dominant disease. Patients manifest obesity, hypertension, early-onset coronary artery disease and type 2 diabetes. {ECO:0000269|PubMed:31358993}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.21.71
uniprot
proteins
function
FUNCTION: Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity. {ECO:0000269|PubMed:31358993}.
uniprot
proteins
mass_dalton
28888
uniprot
proteins
protein_family
Elastase subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10620133
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
2307232
uniprot
proteins
pubmed
2834346
uniprot
proteins
pubmed
31358993
uniprot
proteins
pubmed
3427074
uniprot
proteins
pubmed
3646943
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31358993}.
uniprot
proteins