Mms22l
entrez
212377
canonical
uniprot
B1AUR6
canonical
ensembl
ENSMUSG00000045751
resolver
ensp
ENSMUSP00000103857
resolver
ensp
ENSMUSP00000198875
resolver
genesymbol
Mms22l
resolver
uniprot
B7ZN61
resolver
uniprot
D3YXA0
resolver
uniprot
Q6R5F9
resolver
uniprot
Q80UT0
resolver
uniprot_entry
MMS22_MOUSE
resolver
uniprot_sec
B7ZN61
resolver
uniprot_sec
D3YXA0
resolver
uniprot_sec
Q6R5F9
resolver
uniprot_sec
Q80UT0
resolver
amino_acid_sequence
MDGCSAASTFLTDSLELELGTEWCKPPCFSCAFDNREGKFSGESYLASGALKRLILNLDPLPTNFEEDTVELFGFQWVTETALVYSCRELFHLFRQQIFNLESLVQVSCDFGKIATLHAKADSIRQQCVVFLHYIKVFIFRCLKVQEAESHSRPAHPYEALEAQLPSMLVDELRGLLLYIGHLAALPSVTVGAFVNQNQMKLFPPSWHLLHLYLDTHWLVLEILHILGEKLKQVVYGRQFIGQAGDNLTNVSLFEEHCEHLFCDLICLSLNRFDKVMPSEALLISHCPCSCVKELWVLLIHLLDHRRKWSVADSFWNWLNKLLRTLFEKSSDQRRSSVSLTQAKDPLGFSWWISVHVASLYQIDRHGVSDKMKQMESNWSFIEELLKRSVTVQDSILEEQLRMHLHCCLTLCDFWEPNISVVTILWEYYSKNLNSSFSISWLPLKGLTNIIKSPLSMLTLVRNCCSDKQDPDLYKSSSSYIIFLCILAKVVKKAMRTSGPHPWKQVKGRIYSKFHQKRMEELTEVGLQNFFSLFLLLAAVAEIEDVASHVLDLLRFLRPASMSSHGALVWKGQMAFLLMYAQKNLDIGVWAEKLSCEFQEKAKEFLVSKNDEMVQRHALWTLLCIYIDGVQEVFETSSCLYPSHEHLLNDGFSMLLPACRESELRTVLNFLQAVLARIRSVHQQLCQELQRENVDLTVQSSLSAKERPLAAVAGALWRHFFSFLKSQRMTQVVPLSQLADAAADFTLLAVDMPNTAPPDLQPQPVISIIQLFGWDDIIWPQVVARYLSHLLQNSTVYEALSQSSCVSSQSLTIRSWVRCVLQMHIKHLSDPDLLIDVNPEQAVEKEYMEQLAEMTRLLFTLSEVKSVFSKAQIEQLPSPDDPKQALIQFLEAVGVTYRTLQTFSDKSAMVTKSLEYLGEVLKYIKPYLGKKVSSAGLQLTYGIMGILVKSWAHIFATSKAQKLLFRIIDCLLLPHTVLQQDKELPGPMLTAIQKTLPLYLQGICIVCCQSQNPNAYLNQLLRNVIEQYIGRFLPTSPCVSDLGQHPVLLALRNPASVPSMTPLRKHTVHAIRKSYLEFKGSSPPPRLASVLAFVLQLFKDTEMGACDLELLLPGILKCLVLVNEPQVKKLATENLQCMVQTCQVGSEGGPATQLTSLFRQFIQDYGMQYSYQVYSILETVATLNQHVVIQLIPTLTQSLKDSELKWGLGRNIAQREAYSRLLSGLGQVGQGEKQRLEK
uniprot
proteins
function
FUNCTION: Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, MMS22L acts by binding ssDNA. {ECO:0000250|UniProtKB:Q6ZRQ5}.
uniprot
proteins
mass_dalton
140582
uniprot
proteins
post_translational_modification
PTM: Degraded by the ubiquitin-proteasome system upon replication stress. {ECO:0000250|UniProtKB:Q6ZRQ5}.
uniprot
proteins
protein_family
MMS22 family
uniprot
proteins
protein_family
MMS22L subfamily
uniprot
proteins
pubmed
14691545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6ZRQ5}. Chromosome {ECO:0000250|UniProtKB:Q6ZRQ5}. Note=Localizes to DNA damage sites, accumulates at stressed replication forks. Recruited to stalled or collapsed replication forks; directly binds replication protein A complex (RPA/RP-A)-coated single-stranded DNA (ssDNA). {ECO:0000250|UniProtKB:Q6ZRQ5}.
uniprot
proteins