Smpdl3a
entrez
57319
canonical
uniprot
P70158
canonical
ensembl
ENSMUSG00000019872
resolver
ensp
ENSMUSP00000020022
resolver
enst
ENSMUST00000020022
resolver
genesymbol
Smpdl3a
resolver
genesymbol_syn
Asml3a
resolver
uniprot
Q3U8C2
resolver
uniprot_entry
ASM3A_MOUSE
resolver
uniprot_sec
Q3U8C2
resolver
activity_regulation
ACTIVITY REGULATION: Requires micromolar levels of Zn(2+) for activity. Inhibited by millimolar levels of Zn(2+). {ECO:0000269|PubMed:26792860}.
uniprot
proteins
amino_acid_sequence
MALLGNFLCCLLVAWLCGPGLGVPLAPADRAPAVGQFWHVTDLHLDPTYHITDDRTKVCASSKGANASNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQNLFPNLQVFPALGNHDYWPQDQLPIVTSKVYSAVADLWKPWLGEEAISTLKKGGFYSQKVASNPGLRIISLNTNLYYGPNIMTLNKTDPANQFEWLENTLNSSLWNKEKVYIIAHVPVGYLPYATDTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKNGNPLNSVFVAPAVTPVKGVLQKETNNPGVRLFQYKPGDYTLLDMVQYYLNLTEANLKGESNWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQHCKTLQVCAIMNLDSMSYDDCLKQHL
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
ec_number
3.6.1.15
uniprot
proteins
function
FUNCTION: Cyclic-nucleotide phosphodiesterase that acts as a negative regulator of innate immunity by mediating degradation of 2',3'-cGAMP, thereby inhibiting the cGAS-STING signaling (PubMed:37890481). Specifically linearizes 2',3'-cGAMP into 2'5'-bond pGpA and further hydrolyzes pGpA to produce GpA (By similarity). Also has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:26792860). Has in vitro activity with p-nitrophenyl-TMP (By similarity). Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates (By similarity). Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine (By similarity). Has in vitro activity with CDP-ethanolamine (By similarity). Does not have sphingomyelin phosphodiesterase activity (By similarity). {ECO:0000250|UniProtKB:Q92484, ECO:0000269|PubMed:26792860, ECO:0000269|PubMed:37890481}.
uniprot
proteins
mass_dalton
49858
uniprot
proteins
mutagenesis
MUTAGEN 111; /note="H->A,Q: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:26792860"; MUTAGEN 149; /note="H->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:26792860"; MUTAGEN 149; /note="H->Q: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:26792860
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:26095358}.
uniprot
proteins
protein_family
Acid sphingomyelinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25288789
uniprot
proteins
pubmed
26095358
uniprot
proteins
pubmed
26792860
uniprot
proteins
pubmed
37890481
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25288789, ECO:0000269|PubMed:26095358, ECO:0000269|PubMed:26792860}.
uniprot
proteins