ELP6
entrez
54859
canonical
uniprot
Q0PNE2
canonical
ensembl
ENSG00000163832
resolver
ensp
ENSP00000296149
resolver
ensp
ENSP00000402399
resolver
ensp
ENSP00000412593
resolver
ensp
ENSP00000566716
resolver
ensp
ENSP00000566717
resolver
ensp
ENSP00000691815
resolver
enst
ENST00000439305
resolver
enst
ENST00000446787
resolver
genesymbol
ELP6
resolver
genesymbol_syn
ATP1
resolver
genesymbol_syn
C3orf75
resolver
genesymbol_syn
TMEM103
resolver
hgnc
HGNC:25976
resolver
uniprot
C9IYN7
resolver
uniprot
Q9BW57
resolver
uniprot
Q9NXJ3
resolver
uniprot_entry
C9IYN7_HUMAN
resolver
uniprot_entry
ELP6_HUMAN
resolver
uniprot_sec
Q9BW57
resolver
uniprot_sec
Q9NXJ3
resolver
amino_acid_sequence
MFVELNNLLNTTPDRAEQGKLTLLCDAKTDGSFLVHHFLSFYLKANCKVCFVALIQSFSHYSIVGQKLGVSLTMARERGQLVFLEGLKSAVDVVFQAQKEPHPLQFLREANAGNLKPLFEFVREALKPVDSGEARWTYPVLLVDDLSVLLSLGMGAVAVLDFIHYCRATVCWELKGNMVVLVHDSGDAEDEENDILLNGLSHQSHLILRAEGLATGFCRDVHGQLRILWRRPSQPAVHRDQSFTYQYKIQDKSVSFFAKGMSPAVL
uniprot
proteins
function
FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:22854966, PubMed:29332244). Involved in cell migration (By similarity). {ECO:0000250|UniProtKB:Q8BK75, ECO:0000269|PubMed:22854966, ECO:0000303|PubMed:29332244}.
uniprot
proteins
mass_dalton
29793
uniprot
proteins
pathway_participation
PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. {ECO:0000303|PubMed:29332244}.
uniprot
proteins
protein_family
ELP6 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22645656
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22854966
uniprot
proteins
pubmed
29332244
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22645656}. Nucleus {ECO:0000269|PubMed:22645656}. Note=Concentrates in the nucleus upon insulin stimulation. {ECO:0000269|PubMed:22645656}.
uniprot
proteins