Alkal2
entrez
100294583
canonical
uniprot
Q80UG6
canonical
ensembl
ENSMUSG00000054204
resolver
ensp
ENSMUSP00000070037
resolver
ensp
ENSMUSP00000263848
resolver
enst
ENSMUST00000067087
resolver
genesymbol
Alkal2
resolver
genesymbol_syn
Fam150b
resolver
uniprot
G3X9F3
resolver
uniprot_entry
ALKL2_MOUSE
resolver
uniprot_sec
G3X9F3
resolver
amino_acid_sequence
MRVSGRPMLLALLLLLSTVGDRGRAQSRGPADRQTLLRLLVELVQELKKFHIGDSKRLQLLGESDFALGRREATDYGADQEEQRVEIVPRDLRMKDKFLKHLTGPLYFSPKCSKHFHRLYHNTRDCTIPAYYKRCARLLTRLAVSPMCMER
uniprot
proteins
function
FUNCTION: Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK, leading to their activation. Cytokine-binding is sufficient to activate LTK. In contrast, ALKAL2-driven activation of ALK is coupled with heparin-binding to ALK. Stimulation of ALK signaling is involved in neural development and regulation of energy expenditure. {ECO:0000250|UniProtKB:Q6UX46}.
uniprot
proteins
mass_dalton
17496
uniprot
proteins
protein_family
ALKAL family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
151
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6UX46}. Cell membrane {ECO:0000250|UniProtKB:Q6UX46}. Note=Following interaction with receptor tyrosine kinase ALK, associates with the cell membrane, membrane-binding is required to activate ALK. {ECO:0000250|UniProtKB:Q6UX46}.
uniprot
proteins