Tspan17
entrez
306771
canonical
uniprot
Q4V8E0
canonical
ensembl
ENSRNOG00000018122
resolver
ensembl
ENSRNOG00055023117
resolver
ensp
ENSRNOP00000049736
resolver
ensp
ENSRNOP00000071050
resolver
ensp
ENSRNOP00055032253
resolver
enst
ENSRNOT00000086380
resolver
enst
ENSRNOT00055039716
resolver
genesymbol
Tspan17
resolver
genesymbol_syn
Fbxo23
resolver
uniprot
A0A0G2JZH6
resolver
uniprot_entry
A0A0G2JZH6_RAT
resolver
uniprot_entry
TSN17_RAT
resolver
amino_acid_sequence
MPGKHQQFQDPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWGEKGVLSNISGLTDLGGLDPVWLFVVIGGIMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELAAGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDIRLKLELEQQGSIYTKGCVGQFEKWLQDNLIVVAGVLVAIALLQICGICLAQNLVSDIEAVKANW
uniprot
proteins
function
FUNCTION: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (By similarity). Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration (By similarity). {ECO:0000250|UniProtKB:Q96FV3, ECO:0000250|UniProtKB:Q9D7W4}.
uniprot
proteins
mass_dalton
30110
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9D7W4}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 64..84; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 95..115; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 235..255; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins