Ercc1
entrez
13870
canonical
uniprot
P07903
canonical
ensembl
ENSMUSG00000003549
resolver
ensp
ENSMUSP00000003645
resolver
ensp
ENSMUSP00000125655
resolver
enst
ENSMUST00000003645
resolver
enst
ENSMUST00000160369
resolver
genesymbol
Ercc1
resolver
genesymbol_syn
Ercc-1
resolver
uniprot
E9PUM0
resolver
uniprot
Q91VP3
resolver
uniprot_entry
E9PUM0_MOUSE
resolver
uniprot_entry
ERCC1_MOUSE
resolver
uniprot_sec
Q91VP3
resolver
amino_acid_sequence
MDPGKDEESRPQPSGPPTRRKFVIPLEEEEVPCAGVKPLFRSSRNPTIPATSAHVAPQTYAEYAITQPPGGAGATVPTGSEPAAGENPSQTLKTGAKSNSIIVSPRQRGNPVLKFVRNVPWEFGEVIPDYVLGQSTCALFLSLRYHNLHPDYIHERLQSLGKNFALRVLLVQVDVKDPQQALKELAKMCILADCTLVLAWSAEEAGRYLETYKAYEQKPADLLMEKLEQNFLSRATECLTTVKSVNKTDSQTLLATFGSLEQLFTASREDLALCPGLGPQKARRLFEVLHEPFLKVPR
uniprot
proteins
function
FUNCTION: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). {ECO:0000250|UniProtKB:P07992}.
uniprot
proteins
mass_dalton
32910
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Deubiquitinated by USP45. {ECO:0000250|UniProtKB:P07992}.
uniprot
proteins
protein_family
ERCC1/RAD10/SWI10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
3290851
uniprot
proteins
sequence_length
298
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P07992}.
uniprot
proteins