Gna13
entrez
303634
canonical
uniprot
Q6Q7Y5
canonical
ensembl
ENSRNOG00055030463
resolver
ensembl
ENSRNOG00060014659
resolver
ensembl
ENSRNOG00065019674
resolver
ensp
ENSRNOP00055043690
resolver
ensp
ENSRNOP00060019957
resolver
ensp
ENSRNOP00065026533
resolver
enst
ENSRNOT00055052860
resolver
enst
ENSRNOT00060025054
resolver
enst
ENSRNOT00065033168
resolver
genesymbol
Gna13
resolver
uniprot_entry
GNA13_RAT
resolver
amino_acid_sequence
MADFLPSRSVLSVCFPGCVLTNGEAEQQRKSKEIDKCLSREKTYVKRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKGMRVLVDAREKLHIPWGDNKNQVHGDKLMAFDTRAPMAAQGMVETRVFLQYLPAIRALWDDSGIQNAYDRRREFQLGESVKYFLDNLDKLGVPDYIPSQQDILLARRPTKGIHEYDFEIKNVPFKMVDVGGQRSERKRWFECFDSVTSILFLVSSSEFDQVLMEDRLTNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLEEKVQVVSIKDYFLEFEGDPHCLRDVQKFLVECFRGKRRDQQQRPLYHHFTTAINTENIRLVFRDVKDTILHDNLKQLMLQ
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:12176367). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (By similarity). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (By similarity). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (By similarity). In lymphoid follicles, transmits P2RY8- and S1PR2-dependent signals that lead to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:P27601, ECO:0000250|UniProtKB:Q14344, ECO:0000269|PubMed:12176367}.
uniprot
proteins
mass_dalton
44012
uniprot
proteins
mutagenesis
MUTAGEN 226; /note="Q->L: Constitutively active. Interacts with PPP5C, activates its phosphatase activity and translocates PPP5C to the plasma membrane."; /evidence="ECO:0000269|PubMed:12176367
uniprot
proteins
post_translational_modification
PTM: Palmitoylation is critical for proper membrane localization and signaling. {ECO:0000250|UniProtKB:Q14344}.; PTM: Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation. {ECO:0000250|UniProtKB:Q14344}.
uniprot
proteins
protein_family
G(12) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
pubmed
12176367
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12176367}; Peripheral membrane protein {ECO:0000269|PubMed:12176367}; Cytoplasmic side {ECO:0000305|PubMed:12176367}. Cytoplasm {ECO:0000250|UniProtKB:Q14344}. Nucleus {ECO:0000250|UniProtKB:Q14344}. Note=Associated to the plasma membrane via lipid-anchor (By similarity). Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages (By similarity). In round spermatids, also present in the nuclei (By similarity). {ECO:0000250|UniProtKB:Q14344}.
uniprot
proteins