RBM15
entrez
64783
canonical
uniprot
Q96T37
canonical
ensembl
ENSG00000162775
resolver
ensp
ENSP00000358799
resolver
ensp
ENSP00000499776
resolver
genesymbol
RBM15
resolver
genesymbol_syn
OTT
resolver
genesymbol_syn
OTT1
resolver
hgnc
HGNC:14959
resolver
uniprot
A1A693
resolver
uniprot
Q3ZB86
resolver
uniprot
Q4V760
resolver
uniprot
Q5D058
resolver
uniprot
Q5T613
resolver
uniprot
Q86VW9
resolver
uniprot
Q96PE4
resolver
uniprot
Q96SC5
resolver
uniprot
Q96SC6
resolver
uniprot
Q96SC9
resolver
uniprot
Q96SD0
resolver
uniprot
Q96T38
resolver
uniprot
Q9BRA5
resolver
uniprot
Q9H6R8
resolver
uniprot
Q9H9Y0
resolver
uniprot_entry
RBM15_HUMAN
resolver
uniprot_sec
A1A693
resolver
uniprot_sec
Q3ZB86
resolver
uniprot_sec
Q4V760
resolver
uniprot_sec
Q5D058
resolver
uniprot_sec
Q5T613
resolver
uniprot_sec
Q86VW9
resolver
uniprot_sec
Q96PE4
resolver
uniprot_sec
Q96SC5
resolver
uniprot_sec
Q96SC6
resolver
uniprot_sec
Q96SC9
resolver
uniprot_sec
Q96SD0
resolver
uniprot_sec
Q96T38
resolver
uniprot_sec
Q9BRA5
resolver
uniprot_sec
Q9H6R8
resolver
uniprot_sec
Q9H9Y0
resolver
amino_acid_sequence
MRTAGRDPVPRRSPRWRRAVPLCETSAGRRVTQLRGDDLRRPATMKGKERSPVKAKRSRGGEDSTSRGERSKKLGGSGGSNGSSSGKTDSGGGSRRSLHLDKSSSRGGSREYDTGGGSSSSRLHSYSSPSTKNSSGGGESRSSSRGGGGESRSSGAASSAPGGGDGAEYKTLKISELGSQLSDEAVEDGLFHEFKRFGDVSVKISHLSGSGSGDERVAFVNFRRPEDARAAKHARGRLVLYDRPLKIEAVYVSRRRSRSPLDKDTYPPSASVVGASVGGHRHPPGGGGGQRSLSPGGAALGYRDYRLQQLALGRLPPPPPPPLPRDLERERDYPFYERVRPAYSLEPRVGAGAGAAPFREVDEISPEDDQRANRTLFLGNLDITVTESDLRRAFDRFGVITEVDIKRPSRGQTSTYGFLKFENLDMSHRAKLAMSGKIIIRNPIKIGYGKATPTTRLWVGGLGPWVPLAALAREFDRFGTIRTIDYRKGDSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFADTEHRYQQQYLQPLPLTHYELVTDAFGHRAPDPLRGARDRTPPLLYRDRDRDLYPDSDWVPPPPPVRERSTRTAATSVPAYEPLDSLDRRRDGWSLDRDRGDRDLPSSRDQPRKRRLPEESGGRHLDRSPESDRPRKRHCAPSPDRSPELSSSRDRYNSDNDRSSRLLLERPSPIRDRRGSLEKSQGDKRDRKNSASAERDRKHRTTAPTEGKSPLKKEDRSDGSAPSTSTASSKLKSPSQKQDGGTAPVASASPKLCLAWQGMLLLKNSNFPSNMHLLQGDLQVASSLLVEGSTGGKVAQLKITQRLRLDQPKLDEVTRRIKVAGPNGYAILLAVPGSSDSRSSSSSAASDTATSTQRPLRNLVSYLKQKQAAGVISLPVGGNKDKENTGVLHAFPPCEFSQQFLDSPAKALAKSEEDYLVMIIVRGFGFQIGVRYENKKRENLALTLL
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene. {ECO:0000269|PubMed:11344311, ECO:0000269|PubMed:11431691}.
uniprot
proteins
function
FUNCTION: RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}.
uniprot
proteins
mass_dalton
107189
uniprot
proteins
mutagenesis
MUTAGEN 574..578; /note="RDRDR->KDKDK: Decreased, but not abolished methylation by PRMT1."; /evidence="ECO:0000269|PubMed:26575292"; MUTAGEN 578; /note="R->K: Decreased methylation by PRMT1, leading to decreased ubiquitination by CNOT4."; /evidence="ECO:0000269|PubMed:26575292"; MUTAGEN 795; /note="K->A: Disrupts interaction with SETD1B."; /evidence="ECO:0000269|PubMed:22927943"; MUTAGEN 898; /note="K->A: Disrupts interaction with SETD1B."; /evidence="ECO:0000269|PubMed:22927943"; MUTAGEN 923; /note="F->A: Disrupts interaction with SETD1B."; /evidence="ECO:0000269|PubMed:22927943
uniprot
proteins
post_translational_modification
PTM: Methylated at Arg-578 by PRMT1, leading to promote ubiquitination by CNOT4 and subsequent degradation by the proteasome. {ECO:0000269|PubMed:26575292}.; PTM: Ubiquitinated by CNOT4 following methylation at Arg-578 by PRMT1. {ECO:0000269|PubMed:26575292}.
uniprot
proteins
protein_family
RRM Spen family
uniprot
proteins
pubmed
11344311
uniprot
proteins
pubmed
11431691
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16129689
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17001072
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19586903
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19786495
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22927943
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24100041
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26575292
uniprot
proteins
pubmed
27602518
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
977
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:24100041}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:24100041}. Nucleus envelope {ECO:0000269|PubMed:19586903}. Nucleus membrane {ECO:0000269|PubMed:19786495}; Peripheral membrane protein {ECO:0000269|PubMed:19786495}. Note=Colocalizes at the nuclear pore with DBP5 and NXF1. {ECO:0000269|PubMed:19786495}.
uniprot
proteins