TRAF5
entrez
7188
canonical
uniprot
O00463
canonical
ensembl
ENSG00000082512
resolver
ensp
ENSP00000261464
resolver
ensp
ENSP00000336825
resolver
ensp
ENSP00000355971
resolver
ensp
ENSP00000609560
resolver
genesymbol
TRAF5
resolver
genesymbol_syn
RNF84
resolver
hgnc
HGNC:12035
resolver
uniprot
B4DIS9
resolver
uniprot
B4E0A2
resolver
uniprot
Q6FHY1
resolver
uniprot_entry
TRAF5_HUMAN
resolver
uniprot_sec
B4DIS9
resolver
uniprot_sec
B4E0A2
resolver
uniprot_sec
Q6FHY1
resolver
amino_acid_sequence
MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDLEDL
uniprot
proteins
function
FUNCTION: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. {ECO:0000269|PubMed:15121867}.
uniprot
proteins
mass_dalton
64406
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated at Lys-318 by the SCF(FBXL2) complex, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:P70191}.
uniprot
proteins
protein_family
A subfamily
uniprot
proteins
protein_family
TNF receptor-associated factor family
uniprot
proteins
pubmed
10764746
uniprot
proteins
pubmed
10809768
uniprot
proteins
pubmed
10880535
uniprot
proteins
pubmed
10908663
uniprot
proteins
pubmed
11384837
uniprot
proteins
pubmed
11607847
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15121867
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
8999898
uniprot
proteins
pubmed
9153189
uniprot
proteins
pubmed
9162022
uniprot
proteins
pubmed
9177772
uniprot
proteins
pubmed
9275204
uniprot
proteins
pubmed
9488716
uniprot
proteins
pubmed
9511754
uniprot
proteins
pubmed
9642260
uniprot
proteins
pubmed
9718306
uniprot
proteins
pubmed
9774460
uniprot
proteins
pubmed
9774977
uniprot
proteins
sequence_length
557
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:15121867}. Cytoplasm, cytosol {ECO:0000269|PubMed:15121867}.
uniprot
proteins