Chi3l1
entrez
12654
canonical
uniprot
Q61362
canonical
ensembl
ENSMUSG00000064246
resolver
ensp
ENSMUSP00000080717
resolver
ensp
ENSMUSP00000119205
resolver
genesymbol
Chi3l1
resolver
genesymbol_syn
Brp39
resolver
genesymbol_syn
Chil1
resolver
uniprot
B0FEU7
resolver
uniprot
D3Z2P2
resolver
uniprot
Q3U291
resolver
uniprot
Q4FJW9
resolver
uniprot
Q8BKL8
resolver
uniprot
Q99J84
resolver
uniprot_entry
CH3L1_MOUSE
resolver
uniprot_sec
B0FEU7
resolver
uniprot_sec
D3Z2P2
resolver
uniprot_sec
Q3U291
resolver
uniprot_sec
Q4FJW9
resolver
uniprot_sec
Q8BKL8
resolver
uniprot_sec
Q99J84
resolver
amino_acid_sequence
MHTSTEARMGMRAALTGFAVLMLLQSCSAYKLVCYFTSWSQYREGVGSFLPDAIQPFLCTHIIYSFANISSDNMLSTWEWNDESNYDKLNKLKTRNTNLKTLLSVGGWKFGEKRFSEIASNTERRTAFVRSVAPFLRSYGFDGLDLAWLYPRLRDKQYFSTLIKELNAEFTKEVQPGREKLLLSAALSAGKVAIDTGYDIAQIAQHLDFINLMTYDFHGVWRQITGHHSPLFQGQKDTRFDRYSNVNYAVQYMIRLGAQASKLLMGIPTFGKSFTLASSENQLGAPISGEGLPGRFTKEAGTLAYYEICDFLKGAEVHRLSNEKVPFATKGNQWVGYEDKESVKNKVGFLKEKKLAGAMVWALDLDDFQGTCQPKEFFPLTNAIKDALA
uniprot
proteins
function
FUNCTION: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19041398, ECO:0000269|PubMed:19414556, ECO:0000269|PubMed:20558631, ECO:0000269|PubMed:21546314, ECO:0000269|PubMed:22817986}.
uniprot
proteins
mass_dalton
43893
uniprot
proteins
mutagenesis
MUTAGEN 136; /note="L->E: No effect on chiting-binding. No restoration of chitinase activity."; /evidence="ECO:0000269|PubMed:19041398
uniprot
proteins
protein_family
Glycosyl hydrolase 18 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16472595
uniprot
proteins
pubmed
19041398
uniprot
proteins
pubmed
19414556
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20558631
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21546314
uniprot
proteins
pubmed
21866546
uniprot
proteins
pubmed
22817986
uniprot
proteins
pubmed
7970700
uniprot
proteins
sequence_length
389
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space. Cytoplasm. Endoplasmic reticulum. Note=Detected in bronchoalveolar lavage (BAL) fluids. Localizes mainly to endoplasmic reticulum when overexpressed in cells, with some protein also detected throughout the cytoplasm.
uniprot
proteins