Spag6
entrez
50525
canonical
uniprot
Q9JLI7
canonical
ensembl
ENSMUSG00000022783
resolver
ensp
ENSMUSP00000023468
resolver
ensp
ENSMUSP00000312990
resolver
enst
ENSMUST00000023468
resolver
genesymbol
Spag6
resolver
genesymbol
Spag6l
resolver
genesymbol_syn
Pf16
resolver
genesymbol_syn
Spag6
resolver
uniprot
Q497N2
resolver
uniprot
Q8K461
resolver
uniprot_entry
Q497N2_MOUSE
resolver
uniprot_entry
SPAG6_MOUSE
resolver
uniprot_sec
Q8K461
resolver
amino_acid_sequence
MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRPLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKGDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALGYIARHNTELSQAVVDAGAIPLLVLCIQEPEIALKRIAASALSDISKHSPELAQTVVDAGAIAHLAQMILNPDAKLKRQVLSALSQIAKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNACTLIREIAKHTPELSQLIVNAGGVAAVIDCIGSCKGNIRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSICLSEEPEDHIKAAAAWALGQLGRHTPEHARAVAVTNTLPVLLSLYMSPESSEDLQLKSKKAIKNILQKCTYLPALEPFLYDAPPNILKHVVGQFSKVLPHDSKARRLFVTSGGLKKVQEIKAEPGSLLQEYINSINNCYPEEIVRYYSPGYSDTLLQRVDSYQPL
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Spag6 are a cause of hydrocephalus and of male infertility. {ECO:0000269|PubMed:12167721}.
uniprot
proteins
function
FUNCTION: Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. {ECO:0000269|PubMed:10684790, ECO:0000269|PubMed:12167721}.
uniprot
proteins
mass_dalton
55269
uniprot
proteins
pubmed
10684790
uniprot
proteins
pubmed
12167721
uniprot
proteins
pubmed
12391165
uniprot
proteins
pubmed
15827353
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30535028
uniprot
proteins
sequence_length
507
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10684790}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:10684790}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:30535028}. Note=Associated with microtubules. Detected on the sperm flagellum (PubMed:10684790). Localizes in the cilium axoneme in a SPEF1-dependent manner (PubMed:30535028). {ECO:0000269|PubMed:10684790, ECO:0000269|PubMed:30535028}.
uniprot
proteins