DCUN1D2
entrez
55208
canonical
uniprot
Q6PH85
canonical
ensembl
ENSG00000150401
resolver
ensp
ENSP00000330629
resolver
ensp
ENSP00000417706
resolver
ensp
ENSP00000645962
resolver
genesymbol
DCUN1D2
resolver
genesymbol_syn
C13orf17
resolver
genesymbol_syn
DCUN1L2
resolver
hgnc
HGNC:20328
resolver
uniprot
Q5JSA5
resolver
uniprot
Q5JSA6
resolver
uniprot
Q5JSA7
resolver
uniprot
Q9NVJ1
resolver
uniprot
Q9NXR6
resolver
uniprot_entry
DCNL2_HUMAN
resolver
uniprot_sec
Q5JSA5
resolver
uniprot_sec
Q5JSA6
resolver
uniprot_sec
Q5JSA7
resolver
uniprot_sec
Q9NVJ1
resolver
uniprot_sec
Q9NXR6
resolver
amino_acid_sequence
MHKLKSSQKDKVRQFMACTQAGERTAIYCLTQNEWRLDEATDSFFQNPDSLHRESMRNAVDKKKLERLYGRYKDPQDENKIGVDGIQQFCDDLSLDPASISVLVIAWKFRAATQCEFSRKEFLDGMTELGCDSMEKLKALLPRLEQELKDTAKFKDFYQFTFTFAKNPGQKGLDLEMAVAYWKLVLSGRFKFLDLWNTFLMEHHKRSIPRDTWNLLLDFGNMIADDMSNYDEEGAWPVLIDDFVEYARPVVTGGKRSLF
uniprot
proteins
function
FUNCTION: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and plays an essential role in the regulation of SCF (SKP1-CUL1-F-box protein)-type complexes activity. {ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:26906416}.
uniprot
proteins
mass_dalton
30179
uniprot
proteins
mutagenesis
MUTAGEN 211; /note="D->A: Loss of interaction with CUL1, CUL2, CUL3, CULA4, CULA5 CAND1 and RBX1; when associated with R-235 and A-241. Does not affect both nucleus and cytoplasm localization; when associated with R-235 and A-241."; /evidence="ECO:0000269|PubMed:26906416"; MUTAGEN 235; /note="A->R: Loss of interaction with CUL1, CUL2, CUL3, CULA4, CULA5 CAND1 and RBX1; when associated with A-211 and A-241. Does not affect both nucleus and cytoplasm localization; when associated with A-211 and A-241."; /evidence="ECO:0000269|PubMed:26906416"; MUTAGEN 241; /note="D->A: Loss of interaction with CUL1, CUL2, CUL3, CULA4, CULA5 CAND1 and RBX1; when associated with A-211 and R-235. Does not affect both nucleus and cytoplasm localization; when associated with A-211 and R-235."; /evidence="ECO:0000269|PubMed:26906416
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19617556
uniprot
proteins
pubmed
23201271
uniprot
proteins
pubmed
26906416
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26906416}. Nucleus {ECO:0000269|PubMed:26906416}.
uniprot
proteins