Il17re
entrez
57890
canonical
uniprot
Q8BH06
canonical
ensembl
ENSMUSG00000043088
resolver
ensp
ENSMUSP00000054378
resolver
ensp
ENSMUSP00000062103
resolver
ensp
ENSMUSP00000098626
resolver
ensp
ENSMUSP00000145345
resolver
ensp
ENSMUSP00000145384
resolver
genesymbol
Il17re
resolver
uniprot
Q3I5F0
resolver
uniprot
Q6NSU9
resolver
uniprot
Q8C5D0
resolver
uniprot
Q8K4C1
resolver
uniprot
Q8R335
resolver
uniprot_entry
I17RE_MOUSE
resolver
uniprot_sec
Q3I5F0
resolver
uniprot_sec
Q6NSU9
resolver
uniprot_sec
Q8C5D0
resolver
uniprot_sec
Q8K4C1
resolver
uniprot_sec
Q8R335
resolver
amino_acid_sequence
MGSPRLAALLLSLPLLLIGLAVSARVACPCLRSWTSHCLLAYRVDKRFAGLQWGWFPLLVRKSKSPPKFEDYWRHRTPASFQRKLLGSPSLSEESHRISIPSSAISHRGQRTKRAQPSAAEGREHLPEAGSQKCGGPEFSFDLLPEVQAVRVTIPAGPKASVRLCYQWALECEDLSSPFDTQKIVSGGHTVDLPYEFLLPCMCIEASYLQEDTVRRKKCPFQSWPEAYGSDFWQSIRFTDYSQHNQMVMALTLRCPLKLEASLCWRQDPLTPCETLPNATAQESEGWYILENVDLHPQLCFKFSFENSSHVECPHQSGSLPSWTVSMDTQAQQLTLHFSSRTYATFSAAWSDPGLGPDTPMPPVYSISQTQGSVPVTLDLIIPFLRQENCILVWRSDVHFAWKHVLCPDVSHRHLGLLILALLALTALVGVVLVLLGRRLLPGSGRTRPVLLLHAADSEAQRRLVGALAELLRTALGGGRDVIVDLWEGTHVARIGPLPWLWAARERVAREQGTVLLLWNCAGPSTACSGDPQAASLRTLLCAAPRPLLLAYFSRLCAKGDIPRPLRALPRYRLLRDLPRLLRALDAQPATLASSWSHLGAKRCLKNRLEQCHLLELEAAKDDYQGSTNSPCGFSCL
uniprot
proteins
function
FUNCTION: Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 may be either cytoplasmic inactive or dominant active forms. Isoform 2 and isoform 3 may act as soluble decoy receptors. {ECO:0000269|PubMed:16310341, ECO:0000269|PubMed:21982598, ECO:0000269|PubMed:21993849}.
uniprot
proteins
mass_dalton
70833
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16310341
uniprot
proteins
pubmed
21982598
uniprot
proteins
pubmed
21993848
uniprot
proteins
pubmed
21993849
uniprot
proteins
sequence_length
637
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 415..435; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins