HSD17B12
entrez
51144
canonical
uniprot
Q53GQ0
canonical
ensembl
ENSG00000149084
resolver
ensp
ENSP00000278353
resolver
genesymbol
HSD17B12
resolver
genesymbol_syn
SDR12C1
resolver
hgnc
HGNC:18646
resolver
uniprot
A8K9B0
resolver
uniprot
D3DR23
resolver
uniprot
Q96EA9
resolver
uniprot
Q96JU2
resolver
uniprot
Q9Y6G8
resolver
uniprot_entry
DHB12_HUMAN
resolver
uniprot_sec
A8K9B0
resolver
uniprot_sec
D3DR23
resolver
uniprot_sec
Q96EA9
resolver
uniprot_sec
Q96JU2
resolver
uniprot_sec
Q9Y6G8
resolver
amino_acid_sequence
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSIISNLPSWIYLKIVMNMNKSTRAHYLKKTKKN
uniprot
proteins
ec_number
1.1.1.330
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
function
FUNCTION: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:16166196}.
uniprot
proteins
mass_dalton
34324
uniprot
proteins
mutagenesis
MUTAGEN 196; /note="V->W: No effect."; /evidence="ECO:0000269|PubMed:16166196"; MUTAGEN 234; /note="F->A: Allows the conversion of androstenedione to testosterone."; /evidence="ECO:0000269|PubMed:16166196
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000269|PubMed:12482854}.; PATHWAY: Steroid biosynthesis; estrogen biosynthesis. {ECO:0000269|PubMed:16166196}.
uniprot
proteins
protein_family
17-beta-HSD 3 subfamily
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
12482854
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16113833
uniprot
proteins
pubmed
16166196
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
20937905
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
312
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12482854}; Multi-pass membrane protein {ECO:0000269|PubMed:12482854}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 182..202; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 271..291; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins