Ttll5
entrez
320244
canonical
uniprot
Q8CHB8
canonical
ensembl
ENSMUSG00000012609
resolver
ensp
ENSMUSP00000039939
resolver
ensp
ENSMUSP00000048809
resolver
ensp
ENSMUSP00000134874
resolver
ensp
ENSMUSP00000310919
resolver
ensp
ENSMUSP00000310920
resolver
ensp
ENSMUSP00000310922
resolver
ensp
ENSMUSP00000310924
resolver
ensp
ENSMUSP00000310925
resolver
ensp
ENSMUSP00000310928
resolver
ensp
ENSMUSP00000310933
resolver
ensp
ENSMUSP00000310935
resolver
enst
ENSMUST00000040273
resolver
genesymbol
Ttll5
resolver
genesymbol_syn
Kiaa0998
resolver
uniprot
A4Q9E7
resolver
uniprot
E9Q425
resolver
uniprot
Q3V468
resolver
uniprot
Q8C1F0
resolver
uniprot
Q8CFV5
resolver
uniprot
Q9CVS6
resolver
uniprot_entry
E9Q425_MOUSE
resolver
uniprot_entry
TTLL5_MOUSE
resolver
uniprot_sec
A4Q9E7
resolver
uniprot_sec
Q3V468
resolver
uniprot_sec
Q8C1F0
resolver
uniprot_sec
Q8CFV5
resolver
uniprot_sec
Q9CVS6
resolver
amino_acid_sequence
MPVVMARDLEETASSSEDEDLANQEDHPCIMWTGGCRRIPVLVFHAEAILTKDNNIRVIGERYHLSYKIVRTDSRLVRSILTAHGFHEVHPSSTDYNLMWTGSHLKPFLLRTLSEAQKVNHFPRSYELTRKDRLYKNIIRMQHTHGFKAFHILPQTFLLPAEYAEFCNSYSKDRGPWIVKPVASSRGRGVYLINNPNQISLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVRYDQGSKNIRNQFMHLTNYSVNKKSGDYVSCDDPEVEDYGNKWSMSAMLRYLKQEGKDTTALMAHVEDLIIKTIISAELAIATACKTFVPHRSSCFELYGFDVLIDNTLKPWLLEVNLSPSLACDAPLDLKIKASMISDMFTVVGFVCQDPAQRTSNRSIYPSFESSRRNPFQKPQRTRPLSASDAEMKNLVASAREKVPGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRGNPRRSLLTGRARVSTEGAPELKVESMNSKAKLHAALYERKLLSLEVRKRRRRSGRLRAMRPKYPVIAQPAEMNIKTETESEEEEEVGLDNDDEEQEASQEESAGSLGENQAKYTPSLTVIVENSPRDNAMKVAEWTNKGEPCCKIEAQEPESKFNLMQILQDNGNLSKVQARLAFSAYLQHVQIRLTKDSGGQTLSPSWAAKEDEQMELVVRFLKRASSNLQHSLRMVLPSRRLALLERRRILAHQLGDFIGVYNKETEQMAEKKSKKKLEEEEEDGVNAESFQEFIRQASEAELEEVLTFYTQKNKSASVFLGTHSKSSKNSSSYSDSGAKGDHPETIQEVKIKQPKQQQATEIHADKLSRFTTSSGKEAKLVYTNCSSFCSPAAVLLQRLPSSHLSSVITTSALSAGPGHHASLSQIPPAVPSLPHQPALLLSPVPDNAPPSIHSGTQNVSPAGLPRCRSGSYTIGPFSSFQSAAHIYSQKLSRPSSAKAAGSCHPHKHHSGIAKTQKEGEDVSLNRRYNQSLVTAELQRLAEKQAARQYSPASHISLLTQQVTNLNLASSVINRSSASTPPTLRPVISPSGPTWSIQPDLHASETHSSPPGSRSLQTGGFAWEGEVENNAYSKTTGVVPQHKYHPTAGSYQLHFALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSSLWTMNNGPGCRISSATTGGQKPNTLPQKVVAPPNSSTLVSKPASNHKQVLRKPASQRASKGSSAEGQLNGLQSSLNPAAFMPITNSTGSLEAPQVIFARSKPLPTQSGALATVIGQRKSKSVKSGTI
uniprot
proteins
ec_number
6.3.2.-
uniprot
proteins
function
FUNCTION: Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:17499049). Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step (PubMed:17499049). Preferentially modifies the alpha-tubulin tail over a beta-tail (PubMed:17499049). Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules (By similarity). Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (By similarity). {ECO:0000250|UniProtKB:Q6EMB2, ECO:0000269|PubMed:17499049}.
uniprot
proteins
mass_dalton
147715
uniprot
proteins
protein_family
Tubulin--tyrosine ligase family
uniprot
proteins
pubmed
12465718
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17499049
uniprot
proteins
sequence_length
1328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:17499049}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17499049}. Nucleus {ECO:0000250|UniProtKB:Q6EMB2}. Cytoplasm {ECO:0000250, ECO:0000250|UniProtKB:Q6EMB2}. Note=In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid (By similarity). Localized to the base of the connecting cilium between the basal body and the adjacent daughter centriole of the cilium. {ECO:0000250|UniProtKB:Q6EMB2}.
uniprot
proteins