Rab6a
entrez
19346
canonical
uniprot
P35279
canonical
ensembl
ENSMUSG00000030704
resolver
ensp
ENSMUSP00000032946
resolver
ensp
ENSMUSP00000095852
resolver
genesymbol
Rab6a
resolver
genesymbol_syn
Rab6
resolver
genesymbol_syn
Rab6A
resolver
uniprot
Q0PD54
resolver
uniprot
Q3U4W5
resolver
uniprot
Q542M6
resolver
uniprot
Q8R2Z7
resolver
uniprot
Q8VEE5
resolver
uniprot
Q9JJD4
resolver
uniprot_entry
Q0PD54_MOUSE
resolver
uniprot_entry
Q3U4W5_MOUSE
resolver
uniprot_entry
RAB6A_MOUSE
resolver
uniprot_sec
Q542M6
resolver
uniprot_sec
Q8R2Z7
resolver
uniprot_sec
Q8VEE5
resolver
uniprot_sec
Q9JJD4
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:P20340}.
uniprot
proteins
amino_acid_sequence
MSAGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVNEGGCSC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Recruits VPS13B to the Golgi membrane. Plays a role in neuron projection development. {ECO:0000250|UniProtKB:P20340}.
uniprot
proteins
mass_dalton
23590
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="Q->V: Loss of binding to rabkinesin-6."; /evidence="ECO:0000269|PubMed:9438855"; MUTAGEN 27; /note="T->N: Loss of binding to rabkinesin-6; when associated with L-73."; /evidence="ECO:0000269|PubMed:9438855"; MUTAGEN 46; /note="I->E: Loss of binding to rabkinesin-6."; /evidence="ECO:0000269|PubMed:9438855"; MUTAGEN 72; /note="Q->L: Loss of binding to rabkinesin-6; when associated with N-28."; /evidence="ECO:0000269|PubMed:9438855
uniprot
proteins
post_translational_modification
PTM: Prenylated. {ECO:0000250|UniProtKB:P20340}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1555775
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18997784
uniprot
proteins
pubmed
20360680
uniprot
proteins
pubmed
20643351
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23737971
uniprot
proteins
pubmed
31218450
uniprot
proteins
pubmed
9438855
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:31218450}; Lipid-anchor {ECO:0000250|UniProtKB:P20340}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000269|PubMed:31218450}; Peripheral membrane protein {ECO:0000305}. Note=BICD2 facilitates its targeting to Golgi apparatus membrane. {ECO:0000250|UniProtKB:P20340}.
uniprot
proteins