SPRR2A
entrez
6700
canonical
uniprot
P35326
canonical
ensembl
ENSG00000241794
resolver
ensp
ENSP00000376423
resolver
enst
ENST00000392653
resolver
genesymbol
SPRR2A
resolver
hgnc
HGNC:11261
resolver
uniprot
B2R4T3
resolver
uniprot
D3DV35
resolver
uniprot
Q5T529
resolver
uniprot_entry
SPR2A_HUMAN
resolver
uniprot_sec
B2R4T3
resolver
uniprot_sec
D3DV35
resolver
uniprot_sec
Q5T529
resolver
amino_acid_sequence
MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPPPKCPQPCPPQQCQQKYPPVTPSPPCQSKYPPKSK
uniprot
proteins
function
FUNCTION: Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (PubMed:34735226). Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (By similarity). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidence is required to confirm this result in vivo (PubMed:8325635). {ECO:0000250|UniProtKB:P0DV37, ECO:0000269|PubMed:34735226, ECO:0000269|PubMed:8325635}.
uniprot
proteins
mass_dalton
7965
uniprot
proteins
post_translational_modification
PTM: Forms five pairs of intrachain disulfide bonds. {ECO:0000269|PubMed:34735226}.
uniprot
proteins
protein_family
Cornifin (SPRR) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
2388825
uniprot
proteins
pubmed
34735226
uniprot
proteins
pubmed
8325635
uniprot
proteins
sequence_length
72
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34735226}. Secreted, extracellular space {ECO:0000269|PubMed:34735226}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:34735226}. Note=Present in intestinal secretory epithelial cells and is secreted into the intestinal lumen. {ECO:0000269|PubMed:34735226}.
uniprot
proteins