Cacna1b
entrez
12287
canonical
uniprot
O55017
canonical
ensembl
ENSMUSG00000004113
resolver
ensp
ENSMUSP00000037416
resolver
ensp
ENSMUSP00000063236
resolver
ensp
ENSMUSP00000100003
resolver
ensp
ENSMUSP00000278900
resolver
ensp
ENSMUSP00000278903
resolver
enst
ENSMUST00000070864
resolver
enst
ENSMUST00000102939
resolver
genesymbol
Cacna1b
resolver
genesymbol_syn
Cach5
resolver
genesymbol_syn
Cacnl1a5
resolver
genesymbol_syn
Cchn1a
resolver
uniprot
A2AIR9
resolver
uniprot
A2AIS0
resolver
uniprot
Q60609
resolver
uniprot_entry
A2AIR9_MOUSE
resolver
uniprot_entry
A2AIS0_MOUSE
resolver
uniprot_entry
CAC1B_MOUSE
resolver
uniprot_sec
Q60609
resolver
activity_regulation
ACTIVITY REGULATION: Is specifically blocked by omega-conotoxin GVIA (By similarity). Is specifically blocked by omega-conotoxin MVIIA (ziconotide) (By similarity). Is insensitive to dihydropyridines (DHP). {ECO:0000250|UniProtKB:Q00975, ECO:0000250|UniProtKB:Q02294}.
uniprot
proteins
amino_acid_sequence
MVRFGDELGGRYGGTGGGERARGGGAGGAGGPGQGGLPPGQRVLYKQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDTEPVGDFPCGKDPPARQCDGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDVLKRAATKKSRNDLIHAEEGEDRFVDLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRYASTRHVRPDMKTHMDRPLVVEPGRDGLRGPVGSKSKPEGTEATESADLPRRHHRHRDRDKTSATAPAGGEQDRTESTETGAREERARPRRSHSKETPGADTQVRCERSRRHHRRGSPEEATEREPRRHRAHRHAQDSSKEGTAPVLVPKGERRARHRGPRTGPREAENNEEPTRRHRARHKVPPTLQPPEREAAEKESNAVEGDKETRNHQPKEPHCDLEAIAVTGVGPLHMLPSTCLQKVDEQPEDADNQRNVTRMGSQPSDPSTTVHVPVTLTGPPGETPVVPSGNMNLEGQAEGKKEAEADDVLRRGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDSFRNNALKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFMGGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGNRACDPHANASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISSVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQTHQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSATSLSNGGAIQTQESGIKESLSWGTQRTQDALYEARAPLERGHSAEIPVGQSGTLAVDVQMQNMTLRGPDGEPQPGLESQGRAASMPRLAAETQPAPNASPMKRSISTLAPRPHGTQLCSTVLDRPPPSQASHHHHHRCHRRRDKKQRSLEKGPSLSVDPEGAPSTAAGPGLPHGEGSTACRRDRKQERGRSQERRQPSSSSSEKQRFYSCDRFGSREPPQLMPSLSSHPTSPTAALEPAPHPQGSGSVNGSPLMSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPVHFAEGQSGLPAFSPGRLSRGLSEHNALLQKEPLSQPLAPGSRIGSDPYLGQRLDSEASAHTLPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSTGVRARHSYHHPDQDHWC
uniprot
proteins
function
FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). {ECO:0000250|UniProtKB:Q02294}.
uniprot
proteins
mass_dalton
261481
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK. {ECO:0000250|UniProtKB:Q02294}.
uniprot
proteins
protein_family
CACNA1B subfamily
uniprot
proteins
protein_family
Calcium channel alpha-1 subunit (TC 1.A.1.11) family
uniprot
proteins
pubmed
11438518
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24709664
uniprot
proteins
pubmed
8307146
uniprot
proteins
sequence_length
2327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q00975}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 91..114; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 132..152; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 164..182; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 188..211; /note="Helical; Name=S4 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 222..244; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 332..356; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 483..501; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 512..534; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 545..566; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 574..586; /note="Helical; Name=S4 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 605..630; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 683..709; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1141..1159; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1168..1192; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1207..1231; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1238..1258; /note="Helical; Name=S4 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1277..1296; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1384..1409; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1465..1483; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1492..1516; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1527..1548; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1555..1573; /note="Helical; Name=S4 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1593..1612; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1675..1698; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q00975
uniprot
proteins