SMARCA1
entrez
6594
canonical
uniprot
P28370
canonical
ensembl
ENSG00000102038
resolver
ensp
ENSP00000360162
resolver
ensp
ENSP00000360163
resolver
ensp
ENSP00000360164
resolver
ensp
ENSP00000601528
resolver
ensp
ENSP00000620360
resolver
ensp
ENSP00000620361
resolver
ensp
ENSP00000620362
resolver
ensp
ENSP00000670411
resolver
ensp
ENSP00000670412
resolver
ensp
ENSP00000670414
resolver
ensp
ENSP00000670415
resolver
enst
ENST00000371121
resolver
enst
ENST00000371123
resolver
enst
ENST00000931469
resolver
enst
ENST00000950301
resolver
enst
ENST00000950302
resolver
enst
ENST00000950303
resolver
genesymbol
SMARCA1
resolver
genesymbol_syn
SNF2L
resolver
genesymbol_syn
SNF2L1
resolver
hgnc
HGNC:11097
resolver
uniprot
A0A0A0MRP6
resolver
uniprot
A0ACI8UP29
resolver
uniprot
B7ZLQ5
resolver
uniprot
Q5JV41
resolver
uniprot
Q5JV42
resolver
uniprot_entry
A0A0A0MRP6_HUMAN
resolver
uniprot_entry
A0ACI8UP29_HUMAN
resolver
uniprot_entry
B7ZLQ5_HUMAN
resolver
uniprot_entry
SMCA1_HUMAN
resolver
uniprot_sec
Q5JV41
resolver
uniprot_sec
Q5JV42
resolver
amino_acid_sequence
MEQDTAAVAATVAAADATATIVVIEDEQPGPSTSQEEGAAAAATEATAATEKGEKKKEKNVSSFQLKLAAKAPKSEKEMDPEYEEKMKADRAKRFEFLLKQTELFAHFIQPSAQKSPTSPLNMKLGRPRIKKDEKQSLISAGDYRHRRTEQEEDEELLSESRKTSNVCIRFEVSPSYVKGGPLRDYQIRGLNWLISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGDKDARAAFIRDEMMPGEWDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAHRIKNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLGDQKLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDIDVLNSSGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVSNSGKMVVLDKLLAKLKEQGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREEAIEAFNAPNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEERIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVFASKESELTDEDITTILERGEKKTAEMNERLQKMGESSLRNFRMDIEQSLYKFEGEDYREKQKLGMVEWIEPPKRERKANYAVDAYFREALRVSEPKIPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKVPRNPDIPNPALAQREEQKKIDGAEPLTPEETEEKEKLLTQGFTNWTKRDFNQFIKANEKYGRDDIDNIAREVEGKSPEEVMEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAPFHQLRIQYGTSKGKNYTEEEDRFLICMLHKMGFDRENVYEELRQCVRNAPQFRFDWFIKSRTAMEFQRRCNTLISLIEKENMEIEERERAEKKKRATKTPMVKFSAFS
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: [Isoform 1]: ATPase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:14609955, PubMed:15310751, PubMed:15640247). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). May promote neurite outgrowth (PubMed:14609955). May be involved in the development of luteal cells (PubMed:16740656). Facilitates nucleosome assembly during DNA replication, ensuring replication fork progression and genomic stability by preventing replication stress and nascent DNA gaps (PubMed:39413208). {ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:15640247, ECO:0000269|PubMed:16740656, ECO:0000269|PubMed:28801535, ECO:0000269|PubMed:39413208}.; FUNCTION: [Isoform 2]: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535). Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751). {ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:28801535}.
uniprot
proteins
mass_dalton
121142
uniprot
proteins
mutagenesis
MUTAGEN 214; /note="K->A: Loss of ATPase activity. No effect on replication fork location."; /evidence="ECO:0000269|PubMed:39413208"; MUTAGEN 214; /note="K->R: No effect on neurite outgrowth."; /evidence="ECO:0000269|PubMed:14609955
uniprot
proteins
protein_family
ISWI subfamily
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
12112843
uniprot
proteins
pubmed
1408766
uniprot
proteins
pubmed
14609955
uniprot
proteins
pubmed
15310751
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15640247
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16740656
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
26030138
uniprot
proteins
pubmed
26740508
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28801535
uniprot
proteins
pubmed
39413208
uniprot
proteins
sequence_length
1042
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28801535, ECO:0000269|PubMed:39413208}. Chromosome {ECO:0000269|PubMed:28801535, ECO:0000269|PubMed:39413208}.
uniprot
proteins