Tgs1
entrez
116940
canonical
uniprot
Q923W1
canonical
ensembl
ENSMUSG00000028233
resolver
ensp
ENSMUSP00000054112
resolver
enst
ENSMUST00000052712
resolver
genesymbol
Tgs1
resolver
genesymbol_syn
Ncoa6ip
resolver
genesymbol_syn
Pimt
resolver
uniprot
A2AJF7
resolver
uniprot
Q6DI60
resolver
uniprot
Q6PEA7
resolver
uniprot
Q8R0W9
resolver
uniprot_entry
TGS1_MOUSE
resolver
uniprot_sec
A2AJF7
resolver
uniprot_sec
Q6DI60
resolver
uniprot_sec
Q6PEA7
resolver
uniprot_sec
Q8R0W9
resolver
amino_acid_sequence
MCCEKWNHVAEMLLFIEDREEEYKILCLCSRAFVEDRKLYNLGLKGYYVKSSGNNAGDQGTEEEEDGHSNGTAESHSPNESDLDSEAKLMRSMGLPIQFGRMSSHENFEMSMNARNKAKVKQKRRKHQKRYLDEMVRESWRNDYEEDDLVVSDDPSSVEHCENNRTCEIQSKAGSEVENLPVENTLAPKLEVPENWEKYWNEYGEGLLWQSWQEKYPDQTLSSEPWNLPDTKEEWEQHYSQLYWYYLEQFQYWEAQGWTFTASQNCDKDVYTSHTEVDQNAESSLKADVMTFSSSPNIVEDEIPGSNDNDHNEIITAINNITVSAEKVEQSQLDSSQHCDEPLSEITGKECPASGGSDSCNGTPKENDISENRSSDQPAKELQESSGTNKGKHRPHHNGADGHESDDDPPEHKPSKVKRSHELDVDENPDSEVDDNGFLLGFKHGSGQKYGGIPNFSHRQVRYLEKNVKYKSKYLDLRKQMPVKSKHILFTEDSGKPFVVCKSKVRSKVEKFLKWVNERVDEETSQDSLSQNKMQDTCTSSDSEEQDMSLEKADNLMETRDPEPEKCQIISSATELEAEKSEVGSLVATVPENCSTEEIPNSPHAETEVEIKKKKKKNKNKKINDLPPEIASVPELAKYWAQRYRLFSRFDDGIKLDKEGWFSVTPEKIAEHIAGRVSQAFRCDVVVDAFCGVGGNTIQFALTGKRVIAIDIDPVKIDLARNNAEVYGIADKIEFICGDFLLLAPCLKADVVFLSPPWGGPDYATAETFDIRTMMSPDGFEIFRLSQKITNNIVYFLPRNADIDQVASLAGLGGQVEIEQNFLNNKLKTITAYFGDLIRRPALLKTSTSEAEV
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation (By similarity). {ECO:0000250|UniProtKB:Q96RS0, ECO:0000269|PubMed:11517327}.
uniprot
proteins
mass_dalton
96790
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
protein_family
Trimethylguanosine synthase family
uniprot
proteins
pubmed
11517327
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
853
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96RS0}. Nucleus, Cajal body {ECO:0000269|PubMed:11517327}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q96RS0}.
uniprot
proteins