P25102
uniprot
P25102
canonical
amino_acid_sequence
MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFTWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQEEKPLKLQVWSGTELTHPQGNPIR
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for histamine, primarily mediating gastric acid secretion. Predominantly expressed in the gastric mucosa, couples to G(s) G alpha proteins upon histamine binding, leading to activation of adenylate cyclase and increased intracellular cyclic AMP (cAMP) levels (By similarity). This signaling cascade stimulates parietal cells to secrete hydrochloric acid, playing a key role in digestive physiology. Also expressed in other tissues, including the heart and central nervous system, where it may contribute to cardiac stimulation and modulate neurotransmitter release (By similarity). {ECO:0000250|UniProtKB:P25021, ECO:0000250|UniProtKB:P97292}.
uniprot
proteins
mass_dalton
40253
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1930188
uniprot
proteins
sequence_length
358
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 21..44; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P25021"; TRANSMEM 54..75; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P25021"; TRANSMEM 92..114; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P25021"; TRANSMEM 134..156; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P25021"; TRANSMEM 175..202; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P25021"; TRANSMEM 233..259; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P25021"; TRANSMEM 269..291; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P25021
uniprot
proteins