Hand1
entrez
15110
canonical
uniprot
Q64279
canonical
ensembl
ENSMUSG00000037335
resolver
ensp
ENSMUSP00000046999
resolver
ensp
ENSMUSP00000124951
resolver
enst
ENSMUST00000036917
resolver
enst
ENSMUST00000160392
resolver
genesymbol
Hand1
resolver
genesymbol_syn
Ehand
resolver
genesymbol_syn
Hxt
resolver
genesymbol_syn
Thing1
resolver
uniprot
Q5SQG1
resolver
uniprot
Q61099
resolver
uniprot_entry
HAND1_MOUSE
resolver
uniprot_entry
Q5SQG1_MOUSE
resolver
uniprot_sec
Q61099
resolver
amino_acid_sequence
MNLVGSYAHHHHHHHSHPPHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGGPPPTTAVAAAAYGPDARPSQSPGRLEALGSRLPKRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQAGDPEAFKAELKKTDGGRESKRKRELPQQPESFPPASGPGEKRIKGRTGWPQQVWALELNQ
uniprot
proteins
function
FUNCTION: Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (PubMed:16759287, PubMed:9500551). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (PubMed:7791788). Acts as a transcriptional repressor of SOX15 (PubMed:16759287). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity). {ECO:0000250|UniProtKB:O96004, ECO:0000269|PubMed:16759287, ECO:0000269|PubMed:7791788, ECO:0000269|PubMed:9500551}.
uniprot
proteins
mass_dalton
23806
uniprot
proteins
mutagenesis
MUTAGEN 107; /note="T->A: Remains exclusively in the nucleolus; when associated with A-109."; /evidence="ECO:0000269|PubMed:17891141"; MUTAGEN 107; /note="T->D: Adopts a nucleus-wide distribution; when associated with D-109."; /evidence="ECO:0000269|PubMed:17891141"; MUTAGEN 109; /note="S->A: Remains exclusively in the nucleolus; when associated with A-107."; /evidence="ECO:0000269|PubMed:17891141"; MUTAGEN 109; /note="S->D: Adopts a nucleus-wide distribution; when associated with D-107."; /evidence="ECO:0000269|PubMed:17891141
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PLK4 disrupts the interaction with MDFIC and leads to translocation into the nucleoplasm, allowing dimerization and transcription factor activity. {ECO:0000269|PubMed:17891141}.
uniprot
proteins
pubmed
10924525
uniprot
proteins
pubmed
16759287
uniprot
proteins
pubmed
17891141
uniprot
proteins
pubmed
7649392
uniprot
proteins
pubmed
7671815
uniprot
proteins
pubmed
7791788
uniprot
proteins
pubmed
9500551
uniprot
proteins
sequence_length
216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:17891141}. Nucleus, nucleolus {ECO:0000269|PubMed:17891141}. Note=Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity.
uniprot
proteins