HTRA1
entrez
5654
canonical
uniprot
Q92743
canonical
ensembl
ENSG00000166033
resolver
ensp
ENSP00000357980
resolver
enst
ENST00000368984
resolver
genesymbol
HTRA1
resolver
genesymbol_syn
HTRA
resolver
genesymbol_syn
PRSS11
resolver
hgnc
HGNC:9476
resolver
uniprot
D3DRE4
resolver
uniprot
Q9UNS5
resolver
uniprot_entry
HTRA1_HUMAN
resolver
uniprot_sec
D3DRE4
resolver
uniprot_sec
Q9UNS5
resolver
amino_acid_sequence
MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
uniprot
proteins
disease_involvement
DISEASE: Note=A variant in the HTRA1 promoter may be associated with increased risk for developing age-related macular degeneration (ARMD), a multifactorial eye disease and common cause of vision loss. {ECO:0000269|PubMed:17053108, ECO:0000269|PubMed:17053109}.; DISEASE: Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 2 (CARASIL2) [MIM:600142]: A cerebrovascular disease characterized by non-hypertensive arteriopathy of cerebral small vessels with subcortical infarcts, alopecia, and spondylosis. Small cerebral arteries show arteriosclerotic changes, fibrous intimal proliferation, and hyaline degeneration with splitting of the intima and/or the internal elastic membrane. Neurologic features include progressive dementia, gait disturbances, extrapyramidal and pyramidal signs, and demyelination of the cerebral white matter with sparing of U fibers. {ECO:0000269|PubMed:19387015}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, 2 (CADASIL2) [MIM:616779]: A cerebrovascular disease characterized by multiple subcortical infarcts, pseudobulbar palsy, dementia, and the presence of granular deposits in small cerebral arteries producing ischemic stroke. {ECO:0000269|PubMed:26063658}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. {ECO:0000269|PubMed:16377621, ECO:0000269|PubMed:20671064, ECO:0000269|PubMed:9852107}.
uniprot
proteins
mass_dalton
51287
uniprot
proteins
mutagenesis
MUTAGEN 328; /note="S->A: Loss of activity."; /evidence="ECO:0000269|PubMed:21297635, ECO:0000269|PubMed:9852107
uniprot
proteins
protein_family
Peptidase S1C family
uniprot
proteins
pubmed
15208355
uniprot
proteins
pubmed
16377621
uniprot
proteins
pubmed
17053108
uniprot
proteins
pubmed
17053109
uniprot
proteins
pubmed
19387015
uniprot
proteins
pubmed
20671064
uniprot
proteins
pubmed
21297635
uniprot
proteins
pubmed
26063658
uniprot
proteins
pubmed
8977104
uniprot
proteins
pubmed
9852107
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21297635}. Secreted {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:9852107}. Cytoplasm, cytosol {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:20671064}. Note=Predominantly secreted (PubMed:15208355). Also found associated with the plasma membrane (PubMed:21297635). {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:21297635}.
uniprot
proteins