LAMP1
entrez
3916
canonical
uniprot
P11279
canonical
ensembl
ENSG00000185896
resolver
ensp
ENSP00000333298
resolver
genesymbol
LAMP1
resolver
hgnc
HGNC:6499
resolver
uniprot
B3KRY3
resolver
uniprot
B4DWL3
resolver
uniprot
Q8WU33
resolver
uniprot
Q96I40
resolver
uniprot
Q9BRD2
resolver
uniprot
Q9NP13
resolver
uniprot_entry
B3KRY3_HUMAN
resolver
uniprot_entry
LAMP1_HUMAN
resolver
uniprot_sec
B4DWL3
resolver
uniprot_sec
Q8WU33
resolver
uniprot_sec
Q96I40
resolver
uniprot_sec
Q9BRD2
resolver
uniprot_sec
Q9NP13
resolver
amino_acid_sequence
MAAPGSARRPLLLLLLLLLLGLMHCASAAMFMVKNGNGTACIMANFSAAFSVNYDTKSGPKNMTFDLPSDATVVLNRSSCGKENTSDPSLVIAFGRGHTLTLNFTRNATRYSVQLMSFVYNLSDTHLFPNASSKEIKTVESITDIRADIDKKYRCVSGTQVHMNNVTVTLHDATIQAYLSNSSFSRGETRCEQDRPSPTTAPPAPPSPSPSPVPKSPSVDKYNVSGTNGTCLLASMGLQLNLTYERKDNTTVTRLLNINPNKTSASGSCGAHLVTLELHSEGTTVLLFQFGMNASSSRFFLQGIQLNTILPDARDPAFKAANGSLRALQATVGNSYKCNAEEHVRVTKAFSVNIFKVWVQAFKVEGGQFGSVEECLLDENSMLIPIAVGGALAGLVLIVLIAYLVGRKRSHAGYQTI
uniprot
proteins
function
FUNCTION: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:37390818). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (PubMed:37390818). Also plays an important role in NK-cells cytotoxicity (PubMed:2022921, PubMed:23632890). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins (PubMed:7685349). {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:23632890, ECO:0000269|PubMed:23847195, ECO:0000269|PubMed:37390818, ECO:0000269|PubMed:7685349}.; FUNCTION: (Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085, PubMed:25972533, PubMed:27605678, PubMed:28448640). Also promotes fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909). {ECO:0000269|PubMed:24970085, ECO:0000269|PubMed:25972533, ECO:0000269|PubMed:27605678, ECO:0000269|PubMed:28448640, ECO:0000269|PubMed:29295909}.; FUNCTION: (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. {ECO:0000269|PubMed:32295904}.
uniprot
proteins
mass_dalton
44882
uniprot
proteins
mutagenesis
MUTAGEN 76; /note="N->S: Complete loss of interaction with Lassa virus protein GPC."; /evidence="ECO:0000269|PubMed:24970085
uniprot
proteins
post_translational_modification
PTM: O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. {ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:8323299}.; PTM: (Microbial infection) The glycosylation of Asn-76 is essential for Lassa virus entry into cells. {ECO:0000269|PubMed:24970085}.
uniprot
proteins
protein_family
LAMP family
uniprot
proteins
pubmed
12754519
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16176980
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
17897319
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
2022921
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2243102
uniprot
proteins
pubmed
22641697
uniprot
proteins
pubmed
23632890
uniprot
proteins
pubmed
23847195
uniprot
proteins
pubmed
24088571
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24970085
uniprot
proteins
pubmed
2584229
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
25972533
uniprot
proteins
pubmed
27605678
uniprot
proteins
pubmed
28448640
uniprot
proteins
pubmed
2912382
uniprot
proteins
pubmed
29295909
uniprot
proteins
pubmed
3131762
uniprot
proteins
pubmed
3198605
uniprot
proteins
pubmed
32295904
uniprot
proteins
pubmed
37390818
uniprot
proteins
pubmed
39284914
uniprot
proteins
pubmed
7685349
uniprot
proteins
pubmed
8323299
uniprot
proteins
pubmed
8517882
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:16176980}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:16176980}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:23847195}; Single-pass type I membrane protein {ECO:0000255}. Cytolytic granule membrane {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:24088571}; Single-pass type I membrane protein {ECO:0000255}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). {ECO:0000250|UniProtKB:P05300, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319}.
uniprot
proteins
transmembrane_region
TRANSMEM 383..410; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000305|PubMed:37390818, ECO:0007744|PDB:8FY5, ECO:0007744|PDB:8FYF
uniprot
proteins