CBR4
entrez
84869
canonical
uniprot
Q8N4T8
canonical
ensembl
ENSG00000145439
resolver
ensp
ENSP00000303525
resolver
ensp
ENSP00000423128
resolver
ensp
ENSP00000538112
resolver
ensp
ENSP00000538113
resolver
ensp
ENSP00000704759
resolver
ensp
ENSP00000704760
resolver
genesymbol
CBR4
resolver
genesymbol_syn
SDR45C1
resolver
hgnc
HGNC:25891
resolver
uniprot
Q8WTW8
resolver
uniprot
Q96K93
resolver
uniprot_entry
CBR4_HUMAN
resolver
uniprot_sec
Q8WTW8
resolver
uniprot_sec
Q96K93
resolver
amino_acid_sequence
MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFVHTDMTKDLKEEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL
uniprot
proteins
ec_number
1.1.1.100
uniprot
proteins
ec_number
1.6.5.10
uniprot
proteins
function
FUNCTION: Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis (PubMed:25203508). The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19000905). As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508). {ECO:0000269|PubMed:19000905, ECO:0000269|PubMed:19571038, ECO:0000269|PubMed:25203508}.
uniprot
proteins
mass_dalton
25301
uniprot
proteins
mutagenesis
MUTAGEN 9; /note="G->S: Unable to restore growth of an OAR1-deficient yeast mutant."; /evidence="ECO:0000269|PubMed:25203508"; MUTAGEN 12; /note="R->A: Strongly reduced ability to restore growth of an OAR1-deficient yeast mutant."; /evidence="ECO:0000269|PubMed:25203508"; MUTAGEN 34; /note="R->A: Strongly reduced ability to restore growth of an OAR1-deficient yeast mutant. Strongly reduces NADPH-dependent reductase activity with acetoacetyl-CoA and 9,10-phenanthrene quinone. No effect on NADH-dependent reductase activities."; /evidence="ECO:0000269|PubMed:25203508"; MUTAGEN 135; /note="S->A: Unable to restore growth of an OAR1-deficient yeast mutant."; /evidence="ECO:0000269|PubMed:25203508"; MUTAGEN 148; /note="Y->A: Unable to restore growth of an OAR1-deficient yeast mutant."; /evidence="ECO:0000269|PubMed:25203508"; MUTAGEN 152; /note="K->A: Unable to restore growth of an OAR1-deficient yeast mutant. Abolishes NADPH-dependent reductase activity with acetoacetyl-CoA. Strongly reduces NADPH-dependent reductase activity with 9,10-phenanthrene quinone. No effect on NADH-dependent reductase activities."; /evidence="ECO:0000269|PubMed:25203508"; MUTAGEN 168; /note="R->E: Strongly reduced ability to restore growth of an OAR1-deficient yeast mutant. Increases NADPH-dependent reductase activity with acetoacetyl-CoA. Reduces NADPH-dependent reductase activity with 9,10-phenanthrene quinone. No effect on NADH-dependent reductase activities."; /evidence="ECO:0000269|PubMed:25203508"; MUTAGEN 169; /note="K->E: Unable to restore growth of an OAR1-deficient yeast mutant. Increases NADPH-dependent reductase activity with acetoacetyl-CoA. Reduces NADPH-dependent reductase activity with 9,10-phenanthrene quinone. No effect on NADH-dependent reductase activities."; /evidence="ECO:0000269|PubMed:25203508
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000269|PubMed:19571038, ECO:0000269|PubMed:25203508}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19000905
uniprot
proteins
pubmed
19571038
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25203508
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:19000905, ECO:0000269|PubMed:19571038}.
uniprot
proteins