Rhob
entrez
64373
canonical
uniprot
P62747
canonical
ensembl
ENSRNOG00000021403
resolver
ensp
ENSRNOP00000101374
resolver
ensp
ENSRNOP00000104619
resolver
ensp
ENSRNOP00000110952
resolver
enst
ENSRNOT00000008008
resolver
enst
ENSRNOT00000095242
resolver
enst
ENSRNOT00000121412
resolver
genesymbol
Rhob
resolver
genesymbol_syn
Arhb
resolver
uniprot
P01121
resolver
uniprot
Q9CUV7
resolver
uniprot_entry
RHOB_RAT
resolver
uniprot_sec
P01121
resolver
uniprot_sec
Q9CUV7
resolver
amino_acid_sequence
MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVANKKDLRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKEGVREVFETATRAALQKRYGSQNGCINCCKVL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
22123
uniprot
proteins
post_translational_modification
PTM: Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome (By similarity). {ECO:0000250}.; PTM: Ubiquitinated via 'Lys-63'-linked ubiquitin chains by the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1; leading to targeting RHOB to lysosomes. {ECO:0000250|UniProtKB:P62745}.
uniprot
proteins
protein_family
Rho family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
13679852
uniprot
proteins
pubmed
1710770
uniprot
proteins
pubmed
8816443
uniprot
proteins
sequence_length
196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Nucleus {ECO:0000250}. Cleavage furrow {ECO:0000250}. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner (By similarity). {ECO:0000250}.
uniprot
proteins