D3ZEN0
uniprot
D3ZEN0
canonical
amino_acid_sequence
MAAIKALQEWCRQQCEGYRDVSITNMTTSFRDGLAFCAILHRHRPDLINFNALRKENIYENNKLAFQVAEEQLGIPALLDAEDMVALKIPDRLSILTYVSQYYNYFHGRSPIGGMAGMKRPSSDSTEELSGKKKVPSQPAKLSSPVPTQRLPLSPARTNPVVQRNEGVSERPSPKAAPGTVGSSVSSICGVCGKHVHLVQRHLADGRLYHRSCFRCKQCSSTLHSGAYRATGEPGVFVCTHHSSEAVSVSPKLSNLASRQPGGGIADTRPIGVSQKVLETNGEATPLRARTAAWEHAGGNRAAKGFVQTELTPPATSRVHVGSPAGPRLPMSTVTTTSANSKATTHVTNSSPVGWSSSAQSSTGTSGSRPVVSPSALGAHLSVPQGQAASKGVKTQLNSSTDSSSTAPTPAWTSSSSRTQQAREKFFHNLSPAPAPAPASSSSSHASRVPTVVTAPSGKVSPLVNTSTSKVPSATVVTVPTSKASTVVTAPTSKAPTVVTVPISKAPTVVTAPTSKVSTVVTVPTSKASTVVTAPTSKASTVVTVPTGRGHVVVNTSASKVSGVVDNPAQESSREQALSVLRKALPGLTRAGSQAPSRSSPATSSVLITLPKNEVPPKVPSAKLSHSTTQAFSPTPKMEPTAPLSVGSTSWTSVSLQAGKKSPGISPGIGKTSAVSRPQAEVKGTSGPGPTSQEGQEEGPEGWRARLKPVDKSIPSARALEQKEPVLAEPRAGDTPRKASSSSDSSIHITLTPIQQKRTPCLADSGSSLAAPSPPSRRKKLVVPPTLDVSADWLQPELKKQDDQTRSCKEKTATWGTRESSAILDNDLVSPDEAVTSPVRLHPNYISQEELQRQLQDIERQLDALELRGVELEKRLRAAEGDASEDGLMVDWFRLIHEKQLLLRRESELMYKSKDQCLEERQLDLQGELRRLMEKPEGLKSPQDRKREQELLNQYVNTVNDRSDIVDNLDEDRLREQEEDQMLESMIQNLGLQRKKSKSFLSKIWSSKSKSGQT
uniprot
proteins
function
FUNCTION: Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth. Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250|UniProtKB:Q3TN34, ECO:0000269|PubMed:20008558}.
uniprot
proteins
mass_dalton
108382
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
20008558
uniprot
proteins
sequence_length
1014
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q3TN34}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q3TN34}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q3TN34}. Recycling endosome {ECO:0000250|UniProtKB:Q3TN34}. Cell projection, neuron projection {ECO:0000269|PubMed:20008558}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q3TN34}.
uniprot
proteins