Nrg2
entrez
432361
canonical
uniprot
O35569
canonical
ensembl
ENSRNOG00000019093
resolver
ensp
ENSRNOP00000025901
resolver
ensp
ENSRNOP00000028713
resolver
ensp
ENSRNOP00000087759
resolver
ensp
ENSRNOP00000093404
resolver
enst
ENSRNOT00000025902
resolver
enst
ENSRNOT00000028713
resolver
enst
ENSRNOT00000097771
resolver
enst
ENSRNOT00000119243
resolver
genesymbol
Nrg2
resolver
genesymbol_syn
Ntak
resolver
uniprot
A0A8I6A510
resolver
uniprot
A0A8I6AHJ7
resolver
uniprot
D4A078
resolver
uniprot
F1LM11
resolver
uniprot
O35073
resolver
uniprot
O35570
resolver
uniprot
O35571
resolver
uniprot
O35572
resolver
uniprot_entry
A0A8I6A510_RAT
resolver
uniprot_entry
A0A8I6AHJ7_RAT
resolver
uniprot_entry
D4A078_RAT
resolver
uniprot_entry
F1LM11_RAT
resolver
uniprot_entry
NRG2_RAT
resolver
uniprot_sec
O35073
resolver
uniprot_sec
O35570
resolver
uniprot_sec
O35571
resolver
uniprot_sec
O35572
resolver
amino_acid_sequence
MRQVCCSALPPPLEKARCSSYSYSDSSSSSSSNNSSSSTSSRSSSRSSSRSSRGSTTTTSSSENSGSNSGSIFRPAAPPEPRPQPQPQPRSPAARRAAARSRAAAAGGMRRDPAPGSSMLLFGVSLACYSPSLKSVQDQAYKAPVVVEGKVQGLAPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVGSCAPLERNQRYIFFLEPTEQPLVFKTAFAPVDPNGKNIKKEVGKILCTDCATRPKLKKMKSQTGEVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLHVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRRQMHHHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRREAETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYSQEERRRAAMPPYHDSIDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGADMQRSYDSYYYPAAGPGPRRGACALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRTRGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGCGSASASDDDADDADGALAAESTPFLGLRAAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPTRAKQDSGPL
uniprot
proteins
function
FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
uniprot
proteins
mass_dalton
93777
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. {ECO:0000250}.; PTM: Extensive glycosylation precedes the proteolytic cleavage. {ECO:0000250}.
uniprot
proteins
protein_family
Neuregulin family
uniprot
proteins
pubmed
9168114
uniprot
proteins
pubmed
9348101
uniprot
proteins
sequence_length
868
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Pro-neuregulin-2, membrane-bound isoform]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.; SUBCELLULAR LOCATION: [Neuregulin-2]: Secreted {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 430..450; /note="Helical; Note=Internal signal sequence"; /evidence="ECO:0000255
uniprot
proteins