Mvb12a
entrez
73711
canonical
uniprot
Q78HU3
canonical
ensembl
ENSMUSG00000031813
resolver
ensp
ENSMUSP00000034272
resolver
enst
ENSMUST00000034272
resolver
genesymbol
Mvb12a
resolver
genesymbol_syn
Fam125a
resolver
uniprot_entry
MB12A_MOUSE
resolver
amino_acid_sequence
MDPGTDSAPLAGLVWSSASAPPPPGFSAITCTVEGGTASFGRGFAQKAGYFLCLSTLGIPENPQDNVVVDMQIVMDKGPLPSGFSAVNDPQDIKASVSKKKRMCVKLMPLGTADVVVSDVKLSGKTKTVPGYLRVGDIGGFAIWCKKSKAPRPVPKPRTLSQDMRGLSLDPPKEPSKGSHPERTLSRLGSRASTLRRTDSIYEASSLYGISAMDGVPFTLHPRFEGKSCGPLNLSAFGDLTIKSLADIEKEYNYGFVVEKTAAARLPPSVS
uniprot
proteins
function
FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
28705
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr-202 upon EGF stimulation. Phosphorylation is required for interaction with CD2AP and CIN85/SH3KBP1 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
MVB12 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with F-actin. Some fraction may be nuclear (By similarity). {ECO:0000250}.
uniprot
proteins