Prap1
entrez
22264
canonical
uniprot
Q80XD8
canonical
ensembl
ENSMUSG00000025467
resolver
ensp
ENSMUSP00000026540
resolver
enst
ENSMUST00000026540
resolver
genesymbol
Prap1
resolver
genesymbol_syn
Upa
resolver
uniprot
Q60874
resolver
uniprot_entry
PRAP1_MOUSE
resolver
uniprot_sec
Q60874
resolver
amino_acid_sequence
MKRFLLATCLVAALLWEAGAAPAHQVPVKTKGKHVFPEQETEKVWDTRALEPLEKDNQLGPLLPEPKQKPAAAEEKRPDAMTWVETEDILSHLRSPLQGPELDLDSIDHPMSDDVQDEEVPQSRPILYRQVLQGPEEDLDHLAHSMEDS
uniprot
proteins
function
FUNCTION: Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (PubMed:33168624). Protects the gastrointestinal epithelium from irradiation-induced apoptosis (PubMed:32629119). May play an important role in maintaining normal growth homeostasis in epithelial cells (By similarity). Involved in p53/TP53-dependent cell survival after DNA damage (By similarity). {ECO:0000250|UniProtKB:Q96NZ9, ECO:0000269|PubMed:32629119, ECO:0000269|PubMed:33168624}.
uniprot
proteins
mass_dalton
16798
uniprot
proteins
mutagenesis
MUTAGEN 85; /note="E->V: Impairs its ability to form a complex with triglycerides and MTTP, as well as its ability to facilitate MTTP-mediated lipid transfer and MTTP-mediated apoB lipoprotein assembly and secretion."; /evidence="ECO:0000269|PubMed:33168624
uniprot
proteins
pubmed
10899595
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
32629119
uniprot
proteins
pubmed
33168624
uniprot
proteins
pubmed
9065197
uniprot
proteins
sequence_length
149
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:33168624}. Endoplasmic reticulum {ECO:0000269|PubMed:33168624}.
uniprot
proteins