PSMD4
entrez
5710
canonical
uniprot
P55036
canonical
ensembl
ENSG00000159352
resolver
ensp
ENSP00000357876
resolver
ensp
ENSP00000357879
resolver
enst
ENST00000368881
resolver
genesymbol
PSMD4
resolver
genesymbol_syn
MCB1
resolver
hgnc
HGNC:9561
resolver
uniprot
D3DV16
resolver
uniprot
Q5VWC4
resolver
uniprot
Q5VWC5
resolver
uniprot
Q9NS92
resolver
uniprot_entry
PSMD4_HUMAN
resolver
uniprot_entry
Q5VWC4_HUMAN
resolver
uniprot_sec
D3DV16
resolver
uniprot_sec
Q5VWC5
resolver
uniprot_sec
Q9NS92
resolver
amino_acid_sequence
MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATTGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEFGQAESADIDASSAMDTSEPAKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDGKKDKKEEDKK
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:15826667}.
uniprot
proteins
mass_dalton
40737
uniprot
proteins
protein_family
Proteasome subunit S5A family
uniprot
proteins
pubmed
10921894
uniprot
proteins
pubmed
11585840
uniprot
proteins
pubmed
12970176
uniprot
proteins
pubmed
1317798
uniprot
proteins
pubmed
14585839
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15147878
uniprot
proteins
pubmed
15280365
uniprot
proteins
pubmed
15340068
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15826667
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19683493
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22645313
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29290612
uniprot
proteins
pubmed
3524692
uniprot
proteins
pubmed
7657640
uniprot
proteins
pubmed
8641424
uniprot
proteins
pubmed
9488668
uniprot
proteins
sequence_length
377
uniprot
proteins