Hpf1
entrez
72612
canonical
uniprot
Q8CFE2
canonical
ensembl
ENSMUSG00000038005
resolver
ensp
ENSMUSP00000047235
resolver
ensp
ENSMUSP00000267790
resolver
ensp
ENSMUSP00000267791
resolver
ensp
ENSMUSP00000267792
resolver
enst
ENSMUST00000037190
resolver
genesymbol
Hpf1
resolver
uniprot_entry
HPF1_MOUSE
resolver
amino_acid_sequence
MVGGGGKRRTAGAGPQCEKTVEVKKSKFSEADVSSDLRKEVENLYKLSLPEDFYHFWKFCEELDPEKPADALATSLGLRLVGPYDILAGKHKMKKKPTGLNCNLHWRFYYDPPEFQTIIIGDNKTQYHMGYFRDSPDELPVYVGTNEAKKNCIIIQNGDNVFAAIKLFLMKKLKEVTDRKKISILKNIDEKLTEAARKLGYSLEQRTVKMRQRDKKVVTKTFHGAGLVVPVDKNDVGYRELPETDADLKRICKAVVDAASDEERLKAFAPIQEMMTFVQFANDECDYGMGLELGMDLFCYGSHYFHKVAGQLLPLAYNLLKRDLFAKIIEDHLASRSEENIDQLAG
uniprot
proteins
function
FUNCTION: Cofactor for serine ADP-ribosylation that confers serine specificity on PARP1 and PARP2 and plays a key role in DNA damage response. Initiates the repair of double-strand DNA breaks: recruited to DNA damage sites by PARP1 and PARP2 and switches the amino acid specificity of PARP1 and PARP2 from aspartate or glutamate to serine residues, licensing serine ADP-ribosylation of target proteins. Serine ADP-ribosylation of target proteins, such as histones, promotes decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. HPF1 acts by completing the active site of PARP1 and PARP2: forms a composite active site composed of residues from HPF1 and PARP1 or PARP2. While HPF1 promotes the initiation of serine ADP-ribosylation, it restricts the polymerase activity of PARP1 and PARP2 in order to limit the length of poly-ADP-ribose chains. HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1. {ECO:0000250|UniProtKB:Q9NWY4}.
uniprot
proteins
mass_dalton
39291
uniprot
proteins
protein_family
HPF1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
33589610
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q9NWY4}. Nucleus {ECO:0000250|UniProtKB:Q9NWY4}. Note=Localizes to DNA damage sites; chromatin localization is dependent on PARP1 and PARP2. {ECO:0000250|UniProtKB:Q9NWY4}.
uniprot
proteins