Prg4
entrez
96875
canonical
uniprot
Q9JM99
canonical
ensembl
ENSMUSG00000006014
resolver
ensp
ENSMUSP00000006171
resolver
ensp
ENSMUSP00000125551
resolver
ensp
ENSMUSP00000125677
resolver
ensp
ENSMUSP00000128943
resolver
ensp
ENSMUSP00000233734
resolver
enst
ENSMUST00000006171
resolver
enst
ENSMUST00000161611
resolver
enst
ENSMUST00000162367
resolver
enst
ENSMUST00000164600
resolver
genesymbol
Prg4
resolver
genesymbol_syn
Msf
resolver
genesymbol_syn
Szp
resolver
uniprot
A0A0R4J207
resolver
uniprot
E0CZ58
resolver
uniprot
Q3UEL1
resolver
uniprot
Q3V198
resolver
uniprot_entry
A0A0R4J207_MOUSE
resolver
uniprot_entry
E0CZ58_MOUSE
resolver
uniprot_entry
PRG4_MOUSE
resolver
uniprot_sec
Q3UEL1
resolver
uniprot_sec
Q3V198
resolver
amino_acid_sequence
MGWKILPVCLSLLLPVVLIQQVSSQDLSSCAGRCGEGYSRDATCNCDYNCQHYMECCPDFKRVCSPELSCKGRCFESFARGRECDCDSQCKQYGKCCADYDSFCEEVHNSTSPSSKTAPTPAGASDTIKSTTKRSPKSPTTRTIKVVESEELTEEHSDSENQESSSSSSSSSSTIRKIKSSKNSANRELQKNPNVKDNKKNTPKKKPNPEPPAVDEAGSGLDNGEFKLTPPPPDPPTTPHSKVATSPKTTAAKPVTPKPSLAPNSETSKEASLASNKETTVETKETTATNKQSSASKKKTTSVKETRSAEKTSDKDVEPTSTTPKNSAPTTTKKPVTTTKESKFLPLPQEPEPTTAKEPPPTTKKPEPTTRKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPPPTTKKPEPTTPKEPGPTTPKEPEPTTTKEPEPTTTKEPESTTRKEPEPTTPKEPEPTTPKEPEPTTLKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKEPEPTTPKKPEPTTPKEPVPTTPKEPEPTTPKEPEPTTPKEPEPTTRKEPEPTTPKEPEPTTPKEPEPTTPKKPEPTTTSPKTTTLKATTLAPKVTAPAEEIQNKPEETTPASEDSDDSKTTLKPQKPTKAPKPTKKPTKAPKKPTSTKKPKTPKTRKPKTTPSPLKTTSATPELNTTPLEVMLPTTTIPKQTPNPETAEVNPDHEDADGGEGEKPLIPGPPVLFPTAIPGTDLLAGRLNQGININPMLSDETNLCNGKPVDGLTTLRNGTLVAFRGHYFWMLNPFRPPSPPRRITEVWGIPSPIDTVFTRCNCEGKTFFFKDSQYWRFTNDVVDPGYPKQIVKGFGGLTGKIVAALSIAKYKDRPESVYFFKRGGNIQQYTYKQEPMKKCTGRRPAINYSVYGEAAQVRRRRFERAVGPFQTHTFRIHYSVPMRVSYQDKGFLHNEVKVSTMWRGFPNVVTSAITLPNIRKPDGYDYYAFSKDQYYNIDVPTRTARAITTRSGQTLSKIWYNCP
uniprot
proteins
function
FUNCTION: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. {ECO:0000269|PubMed:15719068}.
uniprot
proteins
mass_dalton
115996
uniprot
proteins
mutagenesis
MUTAGEN 795; /note="C->A: Not cleaved by subtilisin-like proprotein convertase. Not cleaved by subtilisin-like proprotein convertase; when associated with A-1053."; /evidence="ECO:0000269|PubMed:16000300"; MUTAGEN 851..853; /note="CNC->ANA: Cleaved by subtilisin-like proprotein convertase."; /evidence="ECO:0000269|PubMed:16000300"; MUTAGEN 851; /note="C->A: Cleaved by subtilisin-like proprotein convertase."; MUTAGEN 930; /note="C->A: Cleaved by subtilisin-like proprotein convertase."; /evidence="ECO:0000269|PubMed:16000300"; MUTAGEN 949..955; /note="RRRRFER->ARARFEA: Not cleaved by subtilisin-like proprotein convertase 4."; /evidence="ECO:0000269|PubMed:16000300"; MUTAGEN 949..951; /note="RRR->ARA: Cleaved by subtilisin-like proprotein convertase 4."; /evidence="ECO:0000269|PubMed:16000300"; MUTAGEN 955; /note="R->A: Not cleaved by subtilisin-like proprotein convertase 4."; MUTAGEN 1053; /note="C->A: Not cleaved by subtilisin-like proprotein convertase 4. Not cleaved by subtilisin-like proprotein convertase; when associated with A-795."; /evidence="ECO:0000269|PubMed:16000300
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q92954}.; PTM: O-glycosylated; contains glycosaminoglycan chondroitin sulfate and keratan sulfate. O-glycosylated with sialylated oligosaccharides which are predominantly represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated O-glycans. {ECO:0000250|UniProtKB:Q92954}.; PTM: The disulfide bond between Cys-795 and Cys-1053 is essential for protein cleavage. {ECO:0000269|PubMed:16000300}.; PTM: Proteolytically cleaved by cathepsin CTSG. {ECO:0000250|UniProtKB:Q92954}.
uniprot
proteins
pubmed
11124536
uniprot
proteins
pubmed
15719068
uniprot
proteins
pubmed
16000300
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
1054
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q92954}.
uniprot
proteins