Cirsr
entrez
66935
canonical
uniprot
Q9DA19
canonical
ensembl
ENSMUSG00000041777
resolver
ensp
ENSMUSP00000049834
resolver
genesymbol
Cirsr
resolver
genesymbol_syn
Cir
resolver
genesymbol_syn
Cir1
resolver
uniprot
Q3V2N9
resolver
uniprot
Q4KL44
resolver
uniprot
Q52KL9
resolver
uniprot
Q5FW66
resolver
uniprot_entry
CIR1_MOUSE
resolver
uniprot_sec
Q3V2N9
resolver
uniprot_sec
Q4KL44
resolver
uniprot_sec
Q52KL9
resolver
uniprot_sec
Q5FW66
resolver
amino_acid_sequence
MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGVKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQDYVASDCEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKKSDKKKKKLQKSKNKHKKRKNKSPSSSSSSSSSSSSSSSSSSSSSSSSETSDSSSESDNKEKKREKEKRKKKKKTKCSESKSSDCKEDKPKNMLYEELSSSHSDRGKAQEKLRFPKQESSGENSMWVHSASDRTSRSHRHSPEKKGSDRNRGIRSRSRSRAESSRRSRSRSPYRQKHREVRSRPHRSPSEEQKGRKGTRSHGEGDHRREHVR
uniprot
proteins
function
FUNCTION: Regulates transcription and acts as a corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity). May modulate splice site selection during alternative splicing of pre-mRNAs. {ECO:0000250, ECO:0000269|PubMed:15652350}.
uniprot
proteins
mass_dalton
51838
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NEK6. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15652350
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25875095
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:15652350}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q86X95}. Note=Colocalizes with NEK6 in the centrosome. {ECO:0000250|UniProtKB:Q86X95}.
uniprot
proteins