Lat2
entrez
56743
canonical
uniprot
Q9JHL0
canonical
ensembl
ENSMUSG00000040751
resolver
ensp
ENSMUSP00000046900
resolver
ensp
ENSMUSP00000076824
resolver
genesymbol
Lat2
resolver
genesymbol_syn
Lab
resolver
genesymbol_syn
Ntal
resolver
genesymbol_syn
Wbscr15
resolver
genesymbol_syn
Wbscr5
resolver
uniprot
Q3UYF6
resolver
uniprot
Q9JJ29
resolver
uniprot_entry
NTAL_MOUSE
resolver
uniprot_sec
Q3UYF6
resolver
uniprot_sec
Q9JJ29
resolver
amino_acid_sequence
MSAELELLWPVSGLLLLLLGATAWLCVHCSRPGVKRNEKIYEQRNRQENAQSSAAAQTYSLARQVWPGPQMDTAPNKSFERKNKMLFSHLEGPESPRYQNFYKGSNQEPDAAYVDPIPTNYYNWGCFQKPSEDDDSNSYENVLVCKPSTPESGVEDFEDYQNSVSIHQWRESKRTMGAPMSLSGSPDEEPDYVNGDVAAAENI
uniprot
proteins
function
FUNCTION: Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:15477348, ECO:0000269|PubMed:15477350, ECO:0000269|PubMed:15899851}.
uniprot
proteins
mass_dalton
22876
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines following cross-linking of BCR in B-cells, high affinity IgG receptor (FCGR1) in myeloid cells, or high affinity IgE receptor (FCER1) in mast cells; which induces the recruitment of GRB2. {ECO:0000269|PubMed:15477350}.
uniprot
proteins
pubmed
11003705
uniprot
proteins
pubmed
11124535
uniprot
proteins
pubmed
12514734
uniprot
proteins
pubmed
15477348
uniprot
proteins
pubmed
15477350
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15539154
uniprot
proteins
pubmed
15899851
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19144319
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15477348, ECO:0000269|PubMed:15477350}; Single-pass type III membrane protein {ECO:0000269|PubMed:15477348, ECO:0000269|PubMed:15477350}. Note=Present in lipid rafts.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins