PCBP2
entrez
5094
canonical
uniprot
Q15366
canonical
ensembl
ENSG00000197111
resolver
ensp
ENSP00000352228
resolver
ensp
ENSP00000352438
resolver
ensp
ENSP00000390304
resolver
ensp
ENSP00000394116
resolver
ensp
ENSP00000408949
resolver
ensp
ENSP00000448762
resolver
ensp
ENSP00000448927
resolver
genesymbol
PCBP2
resolver
hgnc
HGNC:8648
resolver
uniprot
A0A384N6B9
resolver
uniprot
A8K7X6
resolver
uniprot
B4DXP5
resolver
uniprot
F8VYL7
resolver
uniprot
G3V0E8
resolver
uniprot
I6L8F9
resolver
uniprot
Q32Q82
resolver
uniprot
Q59HD4
resolver
uniprot
Q68Y55
resolver
uniprot
Q6IPF4
resolver
uniprot
Q6PKG5
resolver
uniprot_entry
A0A384N6B9_HUMAN
resolver
uniprot_entry
PCBP2_HUMAN
resolver
uniprot_sec
A8K7X6
resolver
uniprot_sec
B4DXP5
resolver
uniprot_sec
F8VYL7
resolver
uniprot_sec
G3V0E8
resolver
uniprot_sec
I6L8F9
resolver
uniprot_sec
Q32Q82
resolver
uniprot_sec
Q59HD4
resolver
uniprot_sec
Q68Y55
resolver
uniprot_sec
Q6IPF4
resolver
uniprot_sec
Q6PKG5
resolver
amino_acid_sequence
MDTGVIEGGLNVTLTIRLLMHGKEVGSIIGKKGESVKKMREESGARINISEGNCPERIITLAGPTNAIFKAFAMIIDKLEEDISSSMTNSTAASRPPVTLRLVVPASQCGSLIGKGGCKIKEIRESTGAQVQVAGDMLPNSTERAITIAGIPQSIIECVKQICVVMLETLSQSPPKGVTIPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSETGGMGSS
uniprot
proteins
function
FUNCTION: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}.
uniprot
proteins
mass_dalton
38580
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity. {ECO:0000269|PubMed:7607214}.; PTM: (Microbial infection) Proteolytically cleaved by picornavirus proteinase 3CD. {ECO:0000269|PubMed:24371074}.
uniprot
proteins
pubmed
12414943
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16186123
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17426136
uniprot
proteins
pubmed
17526645
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18701464
uniprot
proteins
pubmed
19029303
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19881509
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24371074
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
35322803
uniprot
proteins
pubmed
7607214
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7607214}. Cytoplasm {ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:7607214}. Note=Loosely bound in the nucleus (PubMed:7607214). May shuttle between the nucleus and the cytoplasm (PubMed:7607214). {ECO:0000269|PubMed:7607214}.
uniprot
proteins