Abraxas2
entrez
109359
canonical
uniprot
Q3TCJ1
canonical
ensembl
ENSMUSG00000030965
resolver
ensp
ENSMUSP00000081541
resolver
enst
ENSMUST00000084497
resolver
genesymbol
Abraxas2
resolver
genesymbol_syn
Abro1
resolver
genesymbol_syn
Fam175b
resolver
genesymbol_syn
Kiaa0157
resolver
uniprot
Q3TB08
resolver
uniprot
Q8K0R4
resolver
uniprot
Z4YJY0
resolver
uniprot_entry
ABRX2_MOUSE
resolver
uniprot_entry
Z4YJY0_MOUSE
resolver
uniprot_sec
Q3TB08
resolver
uniprot_sec
Q8K0R4
resolver
amino_acid_sequence
MAASISGYTFSAVCFHSANSNADHEGFLLGEVRQEETFSISDSQISNTEFLQVIEIHNHQPCSQLFSFYDYASKVNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVIHKQLTRILGVPDLVFLLFSFISTANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGTDFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQKKNEKEQERRLQQALLSRQMPSESLEPAFSPRMSYSGFSAEGRSTLAETEPSDPPPPYSDFHPNNQESTLSHSRMERSVFMPRPQAVGSSSYASTSGGLKFTGSGADLLPSQSAAGDSGEESDDSDYENLIDPAESPHSEYSHSKNSRPSTHPDEDPRNTQTSQI
uniprot
proteins
function
FUNCTION: Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (By similarity). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (PubMed:21195082). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage. Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q15018, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:26344097, ECO:0000305|PubMed:21195082}.
uniprot
proteins
mass_dalton
46943
uniprot
proteins
protein_family
Abro1 subfamily
uniprot
proteins
protein_family
FAM175 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21195082
uniprot
proteins
pubmed
22974638
uniprot
proteins
pubmed
24075985
uniprot
proteins
pubmed
26344097
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15018}. Nucleus {ECO:0000250|UniProtKB:Q15018}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q15018}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q15018}. Note=A minor proportion is detected in the nucleus. Translocates into the nucleus in response to DNA damage. Directly binds to microtubules and is detected at the minus end of K-fibers. Co-localizes with NUMA1 at mitotic spindle poles. {ECO:0000250|UniProtKB:Q15018}.
uniprot
proteins