NCR3
entrez
259197
canonical
uniprot
O14931
canonical
ensembl
ENSG00000204475
resolver
ensembl
ENSG00000206430
resolver
ensembl
ENSG00000223833
resolver
ensembl
ENSG00000225211
resolver
ensembl
ENSG00000236315
resolver
ensembl
ENSG00000236979
resolver
ensembl
ENSG00000237103
resolver
ensembl
ENSG00000237808
resolver
ensp
ENSP00000342156
resolver
ensp
ENSP00000365240
resolver
ensp
ENSP00000365241
resolver
ensp
ENSP00000604561
resolver
genesymbol
NCR3
resolver
genesymbol_syn
1C7
resolver
genesymbol_syn
LY117
resolver
hgnc
HGNC:19077
resolver
uniprot
B0S8F2
resolver
uniprot
B0S8F4
resolver
uniprot
B0S8F5
resolver
uniprot
O14930
resolver
uniprot
O14932
resolver
uniprot
O95667
resolver
uniprot
O95668
resolver
uniprot
O95669
resolver
uniprot
Q05D23
resolver
uniprot
Q5ST89
resolver
uniprot
Q5ST90
resolver
uniprot
Q5ST91
resolver
uniprot
Q5ST92
resolver
uniprot
Q5STA3
resolver
uniprot_entry
NCTR3_HUMAN
resolver
uniprot_entry
Q05D23_HUMAN
resolver
uniprot_sec
B0S8F2
resolver
uniprot_sec
B0S8F4
resolver
uniprot_sec
B0S8F5
resolver
uniprot_sec
O14930
resolver
uniprot_sec
O14932
resolver
uniprot_sec
O95667
resolver
uniprot_sec
O95668
resolver
uniprot_sec
O95669
resolver
uniprot_sec
Q5ST89
resolver
uniprot_sec
Q5ST90
resolver
uniprot_sec
Q5ST91
resolver
uniprot_sec
Q5ST92
resolver
uniprot_sec
Q5STA3
resolver
amino_acid_sequence
MAWMLLLILIMVHPGSCALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVVPGKEVRNGTPEFRGRLAPLASSRFLHDHQAELHIRDVRGHDASIYVCRVEVLGLGVGTGNGTRLVVEKEHPQLGAGTVLLLRAGFYAVSFLSVAVGSTVYYQGKCLTWKGPRRQLPAVVPAPLPPPCGSSAHLLPPVPGG
uniprot
proteins
function
FUNCTION: Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. {ECO:0000269|PubMed:10562324, ECO:0000269|PubMed:15784725, ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879, ECO:0000269|PubMed:25315772}.
uniprot
proteins
mass_dalton
21593
uniprot
proteins
protein_family
Natural cytotoxicity receptor (NCR) family
uniprot
proteins
pubmed
10202016
uniprot
proteins
pubmed
10562324
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15784725
uniprot
proteins
pubmed
17208487
uniprot
proteins
pubmed
18055229
uniprot
proteins
pubmed
18852879
uniprot
proteins
pubmed
19528259
uniprot
proteins
pubmed
21422170
uniprot
proteins
pubmed
21444796
uniprot
proteins
pubmed
25315772
uniprot
proteins
pubmed
8824804
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10562324}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins