SH3GLB1
entrez
51100
canonical
uniprot
Q9Y371
canonical
ensembl
ENSG00000097033
resolver
ensp
ENSP00000418744
resolver
ensp
ENSP00000441355
resolver
ensp
ENSP00000473267
resolver
ensp
ENSP00000479919
resolver
ensp
ENSP00000516134
resolver
ensp
ENSP00000567394
resolver
ensp
ENSP00000741507
resolver
ensp
ENSP00000741509
resolver
enst
ENST00000616170
resolver
enst
ENST00000705519
resolver
genesymbol
SH3GLB1
resolver
genesymbol_syn
KIAA0491
resolver
hgnc
HGNC:10833
resolver
uniprot
A0A087WW40
resolver
uniprot
A0A140VJU5
resolver
uniprot
A0A994J549
resolver
uniprot
B4E182
resolver
uniprot
Q5H8U5
resolver
uniprot
Q9H3Z0
resolver
uniprot
Q9NR47
resolver
uniprot
Q9NYA9
resolver
uniprot_entry
A0A087WW40_HUMAN
resolver
uniprot_entry
A0A140VJU5_HUMAN
resolver
uniprot_entry
A0A994J549_HUMAN
resolver
uniprot_entry
SHLB1_HUMAN
resolver
uniprot_sec
B4E182
resolver
uniprot_sec
Q5H8U5
resolver
uniprot_sec
Q9H3Z0
resolver
uniprot_sec
Q9NR47
resolver
uniprot_sec
Q9NYA9
resolver
amino_acid_sequence
MNIMDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSVTPVPSVLPNAIGSSAMASTSGLVITSPSNLSDLKECSGSRKARVLYDYDAANSTELSLLADEVITVFSVVGMDSDWLMGERGNQKGKVPITYLELLN
uniprot
proteins
function
FUNCTION: May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity). {ECO:0000250|UniProtKB:Q9JK48, ECO:0000269|PubMed:11604418, ECO:0000269|PubMed:15452144, ECO:0000269|PubMed:17891140, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:21068542}.
uniprot
proteins
mass_dalton
40796
uniprot
proteins
mutagenesis
MUTAGEN 8; /note="V->M: Abolishes interaction with BAX."; /evidence="ECO:0000269|PubMed:11161816"; MUTAGEN 145; /note="T->A: Reduced CDK5-mediated phosphorylation and impaired dimerization."; /evidence="ECO:0000269|PubMed:21499257"; MUTAGEN 145; /note="T->E: Spontaneous dimerization."; /evidence="ECO:0000269|PubMed:21499257
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization. {ECO:0000269|PubMed:21499257}.
uniprot
proteins
protein_family
Endophilin family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11161816
uniprot
proteins
pubmed
11259440
uniprot
proteins
pubmed
11604418
uniprot
proteins
pubmed
12456676
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15452144
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16227588
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17891140
uniprot
proteins
pubmed
20643123
uniprot
proteins
pubmed
21068542
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21499257
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9455484
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15452144}. Golgi apparatus membrane {ECO:0000269|PubMed:21068542}; Peripheral membrane protein {ECO:0000250}. Mitochondrion outer membrane {ECO:0000269|PubMed:15452144}; Peripheral membrane protein {ECO:0000269|PubMed:15452144}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:17891140}. Midbody {ECO:0000269|PubMed:20643123}. Note=Association with the Golgi apparatus depends on the cell type (By similarity). Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes (PubMed:17891140). {ECO:0000250, ECO:0000269|PubMed:17891140}.
uniprot
proteins