S100A4
entrez
6275
canonical
uniprot
P26447
canonical
ensembl
ENSG00000196154
resolver
ensp
ENSP00000346294
resolver
ensp
ENSP00000357703
resolver
ensp
ENSP00000357704
resolver
ensp
ENSP00000357705
resolver
ensp
ENSP00000525028
resolver
ensp
ENSP00000525029
resolver
ensp
ENSP00000525031
resolver
ensp
ENSP00000525032
resolver
ensp
ENSP00000525033
resolver
ensp
ENSP00000612469
resolver
ensp
ENSP00000612471
resolver
ensp
ENSP00000612472
resolver
enst
ENST00000354332
resolver
enst
ENST00000368714
resolver
enst
ENST00000368715
resolver
enst
ENST00000368716
resolver
enst
ENST00000854969
resolver
enst
ENST00000854970
resolver
enst
ENST00000854972
resolver
enst
ENST00000854973
resolver
enst
ENST00000854974
resolver
enst
ENST00000942410
resolver
enst
ENST00000942412
resolver
enst
ENST00000942413
resolver
genesymbol
S100A4
resolver
genesymbol_syn
CAPL
resolver
genesymbol_syn
MTS1
resolver
hgnc
HGNC:10494
resolver
uniprot
A8K7R8
resolver
uniprot
D3DV46
resolver
uniprot
Q6ICP8
resolver
uniprot_entry
S10A4_HUMAN
resolver
uniprot_sec
A8K7R8
resolver
uniprot_sec
D3DV46
resolver
uniprot_sec
Q6ICP8
resolver
amino_acid_sequence
MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMSNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK
uniprot
proteins
function
FUNCTION: Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:16707441, PubMed:23752197, PubMed:30713770). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:16707441). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed:23752197). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed:26654597, PubMed:30713770). {ECO:0000250|UniProtKB:P07091, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:23752197, ECO:0000269|PubMed:26654597, ECO:0000269|PubMed:30713770}.
uniprot
proteins
mass_dalton
11729
uniprot
proteins
protein_family
S-100 family
uniprot
proteins
pubmed
11836260
uniprot
proteins
pubmed
12379109
uniprot
proteins
pubmed
1329089
uniprot
proteins
pubmed
1384693
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1482346
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16707441
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23024279
uniprot
proteins
pubmed
23752197
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26654597
uniprot
proteins
pubmed
28669632
uniprot
proteins
pubmed
30713770
uniprot
proteins
pubmed
32442400
uniprot
proteins
pubmed
8341667
uniprot
proteins
sequence_length
101
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26654597, ECO:0000269|PubMed:30713770}. Nucleus {ECO:0000269|PubMed:23752197}. Cytoplasm {ECO:0000250|UniProtKB:P07091}.
uniprot
proteins