OSBPL8
entrez
114882
canonical
uniprot
Q9BZF1
canonical
ensembl
ENSG00000091039
resolver
ensp
ENSP00000261183
resolver
ensp
ENSP00000376939
resolver
ensp
ENSP00000376940
resolver
ensp
ENSP00000447893
resolver
ensp
ENSP00000661582
resolver
genesymbol
OSBPL8
resolver
genesymbol_syn
KIAA1451
resolver
genesymbol_syn
ORP8
resolver
genesymbol_syn
OSBP10
resolver
hgnc
HGNC:16396
resolver
uniprot
A8K1T2
resolver
uniprot
E9PE66
resolver
uniprot
E9PE68
resolver
uniprot
Q52LQ3
resolver
uniprot
Q68D75
resolver
uniprot
Q8WXP8
resolver
uniprot
Q9P277
resolver
uniprot_entry
OSBL8_HUMAN
resolver
uniprot_sec
A8K1T2
resolver
uniprot_sec
E9PE66
resolver
uniprot_sec
E9PE68
resolver
uniprot_sec
Q52LQ3
resolver
uniprot_sec
Q68D75
resolver
uniprot_sec
Q8WXP8
resolver
uniprot_sec
Q9P277
resolver
amino_acid_sequence
MEGGLADGEPDRTSLLGDSKDVLGPSTVVANSDESQLLTPGKMSQRQGKEAYPTPTKDLHQPSLSPASPHSQGFERGKEDISQNKDESSLSMSKSKSESKLYNGSEKDSSTSSKLTKKESLKVQKKNYREEKKRATKELLSTITDPSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQKNGQWVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLIIRATSESDGRCWMDALELALKCSSLLKRTMIREGKEHDLSVSSDSTHVTFYGLLRANNLHSGDNFQLNDSEIERQHFKDQDMYSDKSDKENDQEHDESDNEVMGKSEESDTDTSERQDDSYIEPEPVEPLKETTYTEQSHEELGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVNQISGKLKLGKEVLATLEGHWDSEVFITDKKTDNSEVFWNPTPDIKQWRLIRHTVKFEEQGDFESEKLWQRVTRAINAKDQTEATQEKYVLEEAQRQAARDRKTKNEEWSCKLFELDPLTGEWHYKFADTRPWDPLNDMIQFEKDGVIQTKVKHRTPMVSVPKMKHKPTRQQKKVAKGYSSPEPDIQDSSGSEAQSVKPSTRRKKGIELGDIQSSIESIKQTQEEIKRNIMALRNHLVSSTPATDYFLQQKDYFIIFLLILLQVIINFMFK
uniprot
proteins
function
FUNCTION: Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}.
uniprot
proteins
mass_dalton
101196
uniprot
proteins
mutagenesis
MUTAGEN 514..515; /note="HH->AA: Impaired lipid countertransport between the endoplasmic reticulum and the plasma membrane."; /evidence="ECO:0000269|PubMed:26206935
uniprot
proteins
protein_family
OSBP family
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
11483621
uniprot
proteins
pubmed
11735225
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17428193
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
17991739
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21698267
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24424245
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26206935
uniprot
proteins
sequence_length
889
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:26206935}; Single-pass membrane protein {ECO:0000269|PubMed:17991739}. Nucleus membrane {ECO:0000269|PubMed:21698267}. Note=The presence of the N-terminus extension contains an overall negative charge that may explain the weak localization to the cortical endoplasmic reticulum (Probable). {ECO:0000305|PubMed:26206935}.; SUBCELLULAR LOCATION: [Isoform 3]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26206935}; Single-pass membrane protein. Note=Localizes to the cortical endoplasmic reticulum at the endoplasmic reticulum-plasma membrane contact sites. {ECO:0000269|PubMed:26206935}.
uniprot
proteins
transmembrane_region
TRANSMEM 871..888; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins