Ell3
entrez
296102
canonical
uniprot
Q5XFX8
canonical
ensembl
ENSRNOG00000022868
resolver
ensp
ENSRNOP00000101184
resolver
ensp
ENSRNOP00000102332
resolver
enst
ENSRNOT00000140394
resolver
genesymbol
Ell3
resolver
uniprot
A0ABK0LLR3
resolver
uniprot_entry
A0ABK0LLR3_RAT
resolver
uniprot_entry
ELL3_RAT
resolver
amino_acid_sequence
MEGTQEALSGKMRLLFTPAARTSLLMLRLNEAALRALQECQQQQVRPVIAFQGQRGYLRLPGPGWSCLFSFIVSQCGQEGGGLDLVYQRLGRSGPNCLHCLGSLRERLTIWAAMDTIPAPLLAQEHLTEGTRESESWQDSEDEPEGHPQMALQEVSDPLASNHEQSLPGSSSEPMAQWEVRNHTYLSNREPDQPLPSSASQKRLDKKRSAPITTEEPEEKRPRALPLASSPLQGLSNQDSPEEQDWGQDADGDSRLEQSLSVQSASESPSPEEVPDYLLQYSTIHSAEQQQAYEQDFETDYAEYRILHARVGAASQRFTELGAEIKRLQRGTPEHKVLEDKIVQEYKKFRKRYPSYSEEKRRCEYLHEKLSHIKGLILEFEEKNRGS
uniprot
proteins
function
FUNCTION: Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
43803
uniprot
proteins
protein_family
ELL/occludin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
387
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins