ADCY2
entrez
108
canonical
uniprot
Q08462
canonical
ensembl
ENSG00000078295
resolver
ensp
ENSP00000342952
resolver
ensp
ENSP00000585433
resolver
ensp
ENSP00000708745
resolver
ensp
ENSP00000738097
resolver
ensp
ENSP00000738103
resolver
genesymbol
ADCY2
resolver
genesymbol_syn
KIAA1060
resolver
hgnc
HGNC:233
resolver
uniprot
B7Z2C1
resolver
uniprot
Q2NKL8
resolver
uniprot
Q71UM8
resolver
uniprot
Q9UDB2
resolver
uniprot
Q9UPU2
resolver
uniprot_entry
ADCY2_HUMAN
resolver
uniprot_entry
Q71UM8_HUMAN
resolver
uniprot_sec
B7Z2C1
resolver
uniprot_sec
Q2NKL8
resolver
uniprot_sec
Q9UDB2
resolver
uniprot_sec
Q9UPU2
resolver
activity_regulation
ACTIVITY REGULATION: Activated by forskolin (PubMed:15385642). Is not activated by calmodulin. Inhibited by calcium ions, already at micromolar concentration. Activated by the G protein alpha subunit GNAS. Activated by the G protein beta and gamma subunit complex (By similarity). Phosphorylation by RAF1 results in its activation (PubMed:15385642). Phosphorylation by PKC activates the enzyme (By similarity). {ECO:0000250|UniProtKB:P26769, ECO:0000269|PubMed:15385642}.
uniprot
proteins
amino_acid_sequence
MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQSNVAS
uniprot
proteins
ec_number
4.6.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). {ECO:0000250|UniProtKB:P26769, ECO:0000269|PubMed:15385642}.
uniprot
proteins
mass_dalton
123603
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by RAF1. {ECO:0000269|PubMed:15385642}.
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
10470851
uniprot
proteins
pubmed
11549699
uniprot
proteins
pubmed
1427768
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15385642
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21228062
uniprot
proteins
pubmed
8476432
uniprot
proteins
sequence_length
1091
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:15385642}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:11549699, ECO:0000269|PubMed:21228062}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:11549699}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..66; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 76..96; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 108..128; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 133..153; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 159..179; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 187..207; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 602..622; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 628..652; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 680..701; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 734..755; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 763..780; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 801..821; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins