Rraga
entrez
68441
canonical
uniprot
Q80X95
canonical
ensembl
ENSMUSG00000070934
resolver
ensp
ENSMUSP00000088591
resolver
enst
ENSMUST00000091064
resolver
genesymbol
Rraga
resolver
uniprot
B1AXR0
resolver
uniprot
Q8C1S2
resolver
uniprot
Q8CFU3
resolver
uniprot_entry
RRAGA_MOUSE
resolver
uniprot_sec
B1AXR0
resolver
uniprot_sec
Q8C1S2
resolver
uniprot_sec
Q8CFU3
resolver
activity_regulation
ACTIVITY REGULATION: The activation of GTP-binding proteins is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (By similarity). The Ragulator complex functions as a GEF and promotes the active GTP-bound form (By similarity). The GATOR1 complex functions as a GAP and stimulates RRAGA GTPase activity to turn it into its inactive GDP-bound form, preventing mTORC1 recruitment and activation (By similarity). {ECO:0000250|UniProtKB:Q7L523}.
uniprot
proteins
amino_acid_sequence
MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQCKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKHSLLMR
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:23263183). Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagA/RRAGA is in its active form when GTP-bound RagA/RRAGA forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagA/RRAGA heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD) (PubMed:23263183). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:23263183). Involved in the RCC1/Ran-GTPase pathway (By similarity). May play a direct role in a TNF signaling pathway leading to induction of cell death (By similarity). {ECO:0000250|UniProtKB:Q7L523, ECO:0000269|PubMed:23263183}.
uniprot
proteins
mass_dalton
36566
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="Q->L: Maintains GTP-bound state, leading to activate mTORC1. Knockin mice develop normally, but die within 1 day postpartum because of constitutive activation of mTORC1 that prevents response to fasting. Inhibition of mTORC1 is required for neonatal autophagy and thus nutrient homeostasis."; /evidence="ECO:0000269|PubMed:23263183
uniprot
proteins
post_translational_modification
PTM: Polybiquitinated via 'Lys-63'-linked polyubiquitination by RNF152 in response to amino acid starvation: polyubiquitination of the GDP-bound inactive form by RNF152 promotes RRAGA inactivation and interaction with the GATOR1 complex. This does not affect RRAGA degradation. {ECO:0000250|UniProtKB:Q7L523}.
uniprot
proteins
protein_family
GTR/RAG GTP-binding protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23263183
uniprot
proteins
pubmed
25259925
uniprot
proteins
pubmed
29644770
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7L523}. Nucleus {ECO:0000250|UniProtKB:Q7L523}. Lysosome membrane {ECO:0000250|UniProtKB:Q7L523}. Note=Predominantly cytoplasmic. Recruited to the lysosome surface by the Ragulator complex. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. {ECO:0000250|UniProtKB:Q7L523}.
uniprot
proteins