Cndp2
entrez
66054
canonical
uniprot
Q9D1A2
canonical
ensembl
ENSMUSG00000024644
resolver
ensp
ENSMUSP00000025546
resolver
ensp
ENSMUSP00000128696
resolver
enst
ENSMUST00000025546
resolver
enst
ENSMUST00000168419
resolver
genesymbol
Cndp2
resolver
genesymbol_syn
Cn2
resolver
uniprot
Q3TA80
resolver
uniprot
Q3TI32
resolver
uniprot
Q3U7B9
resolver
uniprot
Q99PV1
resolver
uniprot_entry
CNDP2_MOUSE
resolver
uniprot_sec
Q3TA80
resolver
uniprot_sec
Q3TI32
resolver
uniprot_sec
Q3U7B9
resolver
uniprot_sec
Q99PV1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by bestatin. {ECO:0000269|PubMed:15749831}.
uniprot
proteins
amino_acid_sequence
MSALKAVFQYIDENQDRYVKKLAEWVAIQSVSAWPEKRGEIRRMMEVAAADVQRLGGSVELVDIGKQKLPDGSEIPLPPILLGKLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVEREGKLYGRGSTDDKGPVAGWMNALEAYQKTGQEIPVNLRFCLEGMEESGSEGLDELIFAQKDKFFKDVDYVCISDNYWLGKNKPCITYGLRGICYFFIEVECSDKDLHSGVYGGSVHEAMTDLISLMGCLVDKKGKILIPGINDAVAPVTDEEHALYDHIDFDMEEFAKDVGAETLLHSCKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPDMIPEVVSEQVSSYLSKKFAELQSPNKFKVYMGHGGKPWVSDFNHPHYQAGRRALKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRLNYIEGTKMLAAYLYEVSQLKN
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
ec_number
3.4.13.18
uniprot
proteins
function
FUNCTION: Cytosolic metallodipeptidase with broad substrate specificity that catalyzes the hydrolysis of amide bonds in dipeptides and pseudopeptides (PubMed:15749831, PubMed:31587987, PubMed:35705806). Substrates include L-cysteinylglycine, an intermediate metabolite of the gamma-glutamyl cycle of glutathione metabolism (By similarity). Can also hydrolyze threonyl-containing dipeptides (PubMed:31587987). Upon physiological conditions of amino acids and lactate excess can also catalyze a reverse proteolysis reaction, generating N-[(S)-lactoyl]-L-phenylalanine and possibly other N-lactoyl-amino acids which it can also hydrolyze in vitro. N-[(S)-lactoyl]-L-phenylalanine is an exercise-induced metabolite that influences food intake and systemic energy balance (PubMed:35705806). Carnosine is probably not a physiological substrate and L-homocarnosine is not a substrate for this enzyme (PubMed:15749831). Plays a role in the regulation of cell cycle arrest and apoptosis (By similarity). {ECO:0000250|UniProtKB:Q96KP4}.
uniprot
proteins
mass_dalton
52767
uniprot
proteins
mutagenesis
MUTAGEN 166; /note="E->A: Loss of threonyl dipeptidase activity."; /evidence="ECO:0000269|PubMed:31587987"; MUTAGEN 228; /note="H->A: Loss of activity."; /evidence="ECO:0000269|PubMed:18550540
uniprot
proteins
protein_family
Peptidase M20A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15749831
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18550540
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31587987
uniprot
proteins
pubmed
35705806
uniprot
proteins
sequence_length
475
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q96KP4}.
uniprot
proteins