Fkbp1a
entrez
25639
canonical
uniprot
Q62658
canonical
genesymbol
Fkbp1a
resolver
genesymbol_syn
Fkbp1
resolver
uniprot
A0JN04
resolver
uniprot
P97533
resolver
uniprot_entry
FKB1A_RAT
resolver
uniprot_sec
A0JN04
resolver
uniprot_sec
P97533
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by both FK506 and rapamycin.
uniprot
proteins
amino_acid_sequence
MGVQVETISSGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFTLGKQEVIRGWEEGVAQMSVGQRAKLIISPDYAYGATGHPGIIPPHATLVFDVELLKLE
uniprot
proteins
ec_number
5.2.1.8
uniprot
proteins
function
FUNCTION: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
11923
uniprot
proteins
protein_family
FKBP-type PPIase family
uniprot
proteins
protein_family
FKBP1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20431056
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7518616
uniprot
proteins
pubmed
9013543
uniprot
proteins
sequence_length
108
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62942}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P62943}; Peripheral membrane protein {ECO:0000250|UniProtKB:P62943}; Cytoplasmic side {ECO:0000250|UniProtKB:P62943}.
uniprot
proteins