NLRP14
entrez
338323
canonical
uniprot
Q86W24
canonical
ensembl
ENSG00000158077
resolver
ensp
ENSP00000299481
resolver
ensp
ENSP00000562265
resolver
enst
ENST00000299481
resolver
genesymbol
NLRP14
resolver
genesymbol_syn
NALP14
resolver
genesymbol_syn
NOD5
resolver
hgnc
HGNC:22939
resolver
uniprot
Q7RTR6
resolver
uniprot_entry
NAL14_HUMAN
resolver
uniprot_sec
Q7RTR6
resolver
amino_acid_sequence
MADSSSSSFFPDFGLLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVLGDGTEYRNRIKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLIIKPDCNYHNEEDVSWWWCF
uniprot
proteins
function
FUNCTION: Component of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (By similarity). They are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained state, regulating their availability for early embryonic development (By similarity). Cytoplasmic lattices also tightly control ubiquitination during the oocyte-to-embryo transition by trapping E3 ubiquitin-protein ligase UHRF1 in a compact autoinhibited conformation and maintaining SCF ubiquitin ligase complexes inactive (PubMed:41951593). Also plays a role in spermatogenesis by regulating differentiation of primordial germ cell-like cells, possibly by protecting HSPA2 from proteasome-mediated degradation (By similarity). {ECO:0000250|UniProtKB:Q6B966, ECO:0000269|PubMed:41951593}.
uniprot
proteins
mass_dalton
124733
uniprot
proteins
mutagenesis
MUTAGEN 84; /note="L->R: Increased thermal stability of the Pyrin domain."; /evidence="ECO:0000269|PubMed:25004977
uniprot
proteins
protein_family
NLRP family
uniprot
proteins
pubmed
12563287
uniprot
proteins
pubmed
12766759
uniprot
proteins
pubmed
16931801
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
25004977
uniprot
proteins
pubmed
27535533
uniprot
proteins
pubmed
41951593
uniprot
proteins
sequence_length
1093
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6B966}.
uniprot
proteins