COMMD5
entrez
28991
canonical
uniprot
Q9GZQ3
canonical
ensembl
ENSG00000170619
resolver
ensp
ENSP00000304544
resolver
ensp
ENSP00000385793
resolver
ensp
ENSP00000394331
resolver
ensp
ENSP00000433758
resolver
ensp
ENSP00000435552
resolver
ensp
ENSP00000445840
resolver
ensp
ENSP00000548001
resolver
ensp
ENSP00000548002
resolver
ensp
ENSP00000548003
resolver
ensp
ENSP00000602277
resolver
ensp
ENSP00000631553
resolver
ensp
ENSP00000631554
resolver
enst
ENST00000305103
resolver
enst
ENST00000402718
resolver
enst
ENST00000450361
resolver
enst
ENST00000529143
resolver
enst
ENST00000533270
resolver
enst
ENST00000543949
resolver
enst
ENST00000877942
resolver
enst
ENST00000877943
resolver
enst
ENST00000877944
resolver
enst
ENST00000932218
resolver
enst
ENST00000961494
resolver
enst
ENST00000961495
resolver
genesymbol
COMMD5
resolver
hgnc
HGNC:17902
resolver
uniprot
D3DWN7
resolver
uniprot
Q9NVN6
resolver
uniprot
Q9UHX5
resolver
uniprot_entry
COMD5_HUMAN
resolver
uniprot_sec
D3DWN7
resolver
uniprot_sec
Q9NVN6
resolver
uniprot_sec
Q9UHX5
resolver
amino_acid_sequence
MSAVGAATPYLHHPGDSHSGRVSFLGAQLPPEVAAMARLLGDLDRSTFRKLLKFVVSSLQGEDCREAVQRLGVSANLPEEQLGALLAGMHTLLQQALRLPPTSLKPDTFRDQLQELCIPQDLVGDLASVVFGSQRPLLDSVAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGSAYRFEVPTAKFQELRYSVALVLKEMADLEKRCERRLQD
uniprot
proteins
function
FUNCTION: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation (By similarity). Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway (By similarity). Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966). {ECO:0000250|UniProtKB:Q9ERR2, ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129, ECO:0000305|PubMed:21778237}.
uniprot
proteins
mass_dalton
24670
uniprot
proteins
protein_family
COMM domain-containing protein 5 family
uniprot
proteins
pubmed
10918053
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15799966
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21778237
uniprot
proteins
pubmed
23563313
uniprot
proteins
pubmed
23637203
uniprot
proteins
pubmed
25355947
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
37172566
uniprot
proteins
pubmed
38459129
uniprot
proteins
pubmed
38504028
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21778237}. Nucleus {ECO:0000269|PubMed:21778237}.
uniprot
proteins