IFIT1B
entrez
439996
canonical
uniprot
Q5T764
canonical
ensembl
ENSG00000204010
resolver
ensp
ENSP00000360874
resolver
enst
ENST00000371809
resolver
genesymbol
IFIT1B
resolver
genesymbol_syn
IFIT1L
resolver
hgnc
HGNC:23442
resolver
uniprot
A7E245
resolver
uniprot_entry
IFT1B_HUMAN
resolver
uniprot_sec
A7E245
resolver
amino_acid_sequence
MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAYVKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLNALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERALRLAADLNPIF
uniprot
proteins
function
FUNCTION: IFIT1B is likely non-functional, lacking the critical antiviral role of IFIT1. Unlike IFIT1, which is essential in the innate immune response as part of an interferon-dependent multiprotein complex, IFIT1B does not prevent the translation of viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. Consequently, it probably cannot inhibit their translation by competing with the host translation machinery. {ECO:0000269|PubMed:27240734}.
uniprot
proteins
mass_dalton
54993
uniprot
proteins
protein_family
IFIT family
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
27240734
uniprot
proteins
sequence_length
474
uniprot
proteins