H2BW1
entrez
158983
canonical
uniprot
Q7Z2G1
canonical
ensembl
ENSG00000123569
resolver
ensp
ENSP00000354723
resolver
genesymbol
H2BW1
resolver
genesymbol_syn
H2BFWT
resolver
genesymbol_syn
TH2B-175
resolver
hgnc
HGNC:27252
resolver
uniprot
B1AK72
resolver
uniprot
Q147W3
resolver
uniprot_entry
H2BWT_HUMAN
resolver
uniprot_sec
B1AK72
resolver
uniprot_sec
Q147W3
resolver
amino_acid_sequence
MATASAMAGPSSETTSEEQLITQEPKEANSTTSQKQSKQRKRGRHGPRRCHSNCRGDSFATYFRRVLKQVHQGLSLSREAVSVMDSLVHDILDRIATEAGHLARSTKRQTITAWETRMAVRLLLPGQMGKLAESEGTKAVLRTSLYAIQQQRK
uniprot
proteins
function
FUNCTION: Atypical histone H2B that can form nucleosomes structurally and dynamically indistinguishable from those containing conventional H2B. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (PubMed:15475252, PubMed:16449661). However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes (PubMed:16449661). May be important for telomere function and play a role in spermatogenesis (PubMed:16449661, PubMed:19583817). {ECO:0000269|PubMed:15475252, ECO:0000269|PubMed:16449661, ECO:0000269|PubMed:19583817}.
uniprot
proteins
mass_dalton
17050
uniprot
proteins
protein_family
Histone H2B family
uniprot
proteins
pubmed
15475252
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16449661
uniprot
proteins
pubmed
19583817
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:15475252}. Chromosome {ECO:0000269|PubMed:15475252}. Chromosome, telomere {ECO:0000269|PubMed:15475252}.
uniprot
proteins