TMC4
entrez
147798
canonical
uniprot
Q7Z404
canonical
ensembl
ENSG00000167608
resolver
ensembl
ENSG00000273722
resolver
ensembl
ENSG00000274873
resolver
ensembl
ENSG00000274905
resolver
ensembl
ENSG00000276260
resolver
ensembl
ENSG00000277667
resolver
ensembl
ENSG00000277996
resolver
ensembl
ENSG00000278363
resolver
ensp
ENSP00000477627
resolver
ensp
ENSP00000479458
resolver
ensp
ENSP00000597612
resolver
enst
ENST00000617472
resolver
enst
ENST00000619895
resolver
genesymbol
TMC4
resolver
hgnc
HGNC:22998
resolver
uniprot
A0A087WT65
resolver
uniprot
A0A087WVI4
resolver
uniprot
Q7Z5M3
resolver
uniprot
Q8N5E4
resolver
uniprot
Q8TBS7
resolver
uniprot_entry
A0A087WT65_HUMAN
resolver
uniprot_entry
A0A087WVI4_HUMAN
resolver
uniprot_entry
TMC4_HUMAN
resolver
uniprot_sec
Q7Z5M3
resolver
uniprot_sec
Q8N5E4
resolver
uniprot_sec
Q8TBS7
resolver
amino_acid_sequence
MEENPTLESEAWGSSRGWLAPREARGAPCSSPGPSLSSVLNELPSAATLRYRDPGVLPWGALEEEEEDGGRSRKAFTEVTQTELQDPHPSRELPWPMQARRAHRQRNASRDQVVYGSGTKTDRWARLLRRSKEKTKEGLRSLQPWAWTLKRIGGQFGAGTESYFSLLRFLLLLNVLASVLMACMTLLPTWLGGAPPGPPGPDISSPCGSYNPHSQGLVTFATQLFNLLSGEGYLEWSPLFYGFYPPRPRLAVTYLCWAFAVGLICLLLILHRSVSGLKQTLLAESEALTSYSHRVFSAWDFGLCGDVHVRLRQRIILYELKVELEETVVRRQAAVRTLGQQARVWLVRVLLNLLVVALLGAAFYGVYWATGCTVELQEMPLVQELPLLKLGVNYLPSIFIAGVNFVLPPVFKLIAPLEGYTRSRQIVFILLRTVFLRLASLVVLLFSLWNQITCGGDSEAEDCKTCGYNYKQLPCWETVLGQEMYKLLLFDLLTVLAVALLIQFPRKLLCGLCPGALGRLAGTQEFQVPDEVLGLIYAQTVVWVGSFFCPLLPLLNTVKFLLLFYLKKLTLFSTCSPAARTFRASAANFFFPLVLLLGLAISSVPLLYSIFLIPPSKLCGPFRGQSSIWAQIPESISSLPETTQNFLFFLGTQAFAVPLLLISSILMAYTVALANSYGRLISELKRQRQTEAQNKVFLARRAVALTSTKPAL
uniprot
proteins
function
FUNCTION: Voltage-gated chloride channel involved in high-concentration salt taste sensation (PubMed:34429071, PubMed:34468713). Depolarization induced by high NaCl concentration may trigger the activation of TMC4-mediated chloride influx into taste bud cells, helping the return to resting potential (PubMed:34429071). Also allows permeation of organic anions including gluconate, but their current amplitudes at positive potentials are less than that of chloride (PubMed:34429071). Involved in pH and temperature-dependent modulation of salty taste (PubMed:34468713). {ECO:0000269|PubMed:34429071, ECO:0000269|PubMed:34468713}.
uniprot
proteins
mass_dalton
79208
uniprot
proteins
protein_family
TMC family
uniprot
proteins
pubmed
12812529
uniprot
proteins
pubmed
12906855
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
34429071
uniprot
proteins
pubmed
34468713
uniprot
proteins
sequence_length
712
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 250..270; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 349..369; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 395..415; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 426..446; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 484..504; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 543..565; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 593..613; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 655..677; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins