Cib1
entrez
23991
canonical
uniprot
Q9Z0F4
canonical
ensembl
ENSMUSG00000030538
resolver
ensp
ENSMUSP00000070901
resolver
ensp
ENSMUSP00000071401
resolver
ensp
ENSMUSP00000118926
resolver
ensp
ENSMUSP00000145961
resolver
ensp
ENSMUSP00000266981
resolver
ensp
ENSMUSP00000266982
resolver
ensp
ENSMUSP00000356321
resolver
enst
ENSMUST00000065163
resolver
enst
ENSMUST00000071457
resolver
enst
ENSMUST00000206084
resolver
genesymbol
Cib1
resolver
genesymbol_syn
Cib
resolver
genesymbol_syn
Kip
resolver
genesymbol_syn
Prkdcip
resolver
uniprot
A0A0U1RPF3
resolver
uniprot
F6VIA7
resolver
uniprot
Q3TN80
resolver
uniprot
Q8C2K4
resolver
uniprot_entry
A0A0U1RPF3_MOUSE
resolver
uniprot_entry
CIB1_MOUSE
resolver
uniprot_entry
F6VIA7_MOUSE
resolver
uniprot_entry
Q8C2K4_MOUSE
resolver
uniprot_sec
Q3TN80
resolver
amino_acid_sequence
MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPPEQRTVEESLHTRVSFEQILSLPELKANPFKERICMVFSTSPTRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL
uniprot
proteins
function
FUNCTION: Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Also promotes cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells. Forms a complex with TMC6/EVER1 and TMC8/EVER2 in lymphocytes and keratynocytes where CIB1 stabilizes TMC6 and TMC8 levels and reciprocally (By similarity). {ECO:0000250|UniProtKB:Q99828, ECO:0000269|PubMed:16982698, ECO:0000269|PubMed:17975111, ECO:0000269|PubMed:19691476, ECO:0000269|PubMed:20804551, ECO:0000269|PubMed:22128142}.
uniprot
proteins
mass_dalton
21763
uniprot
proteins
pubmed
10051332
uniprot
proteins
pubmed
10826701
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16418530
uniprot
proteins
pubmed
16982698
uniprot
proteins
pubmed
17975111
uniprot
proteins
pubmed
17994197
uniprot
proteins
pubmed
18989529
uniprot
proteins
pubmed
19691476
uniprot
proteins
pubmed
20639889
uniprot
proteins
pubmed
20804551
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22128142
uniprot
proteins
pubmed
29084757
uniprot
proteins
pubmed
29255404
uniprot
proteins
sequence_length
191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q99828}; Lipid-anchor {ECO:0000250|UniProtKB:Q99828}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q99828}. Cell membrane {ECO:0000250|UniProtKB:Q99828}. Apical cell membrane {ECO:0000250|UniProtKB:Q99828}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q99828}. Cell projection, filopodium tip {ECO:0000250|UniProtKB:Q99828}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q99828}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q99828}. Cytoplasm {ECO:0000250|UniProtKB:Q99828}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q99828}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q99828}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q99828}. Nucleus {ECO:0000250|UniProtKB:Q99828}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q99828}. Perikaryon {ECO:0000250|UniProtKB:Q99828}. Note=Colocalized with PPP3R1 at the cell membrane of cardiomyocytes in the hypertrophic heart (By similarity). Colocalized with NBR1 to the perinuclear region. Colocalizes with TAS1R2 in apical regions of taste receptor cells. Colocalized with RAC3 in the perinuclear area and at the cell periphery. Colocalized with PAK1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Redistributed to the cytoskeleton upon platelet aggregation. Translocates from the cytosol to the plasma membrane in a calcium-dependent manner. Colocalized with PLK3 at centrosomes in ductal breast carcinoma cells. {ECO:0000250}.
uniprot
proteins