MCM10
entrez
55388
canonical
uniprot
Q7L590
canonical
ensembl
ENSG00000065328
resolver
ensp
ENSP00000367986
resolver
ensp
ENSP00000418268
resolver
ensp
ENSP00000591494
resolver
ensp
ENSP00000591495
resolver
genesymbol
MCM10
resolver
hgnc
HGNC:18043
resolver
uniprot
A8K9I6
resolver
uniprot
B7ZKZ8
resolver
uniprot
Q3MIR3
resolver
uniprot
Q7LD55
resolver
uniprot
Q96GX4
resolver
uniprot
Q96NB6
resolver
uniprot
Q9H0D7
resolver
uniprot
Q9H3P9
resolver
uniprot
Q9P177
resolver
uniprot_entry
MCM10_HUMAN
resolver
uniprot_sec
A8K9I6
resolver
uniprot_sec
B7ZKZ8
resolver
uniprot_sec
Q3MIR3
resolver
uniprot_sec
Q7LD55
resolver
uniprot_sec
Q96GX4
resolver
uniprot_sec
Q96NB6
resolver
uniprot_sec
Q9H0D7
resolver
uniprot_sec
Q9H3P9
resolver
uniprot_sec
Q9P177
resolver
amino_acid_sequence
MDEEEDNLSLLTALLEENESALDCNSEENNFLTRENGEPDAFDELFDADGDGESYTEEADDGETGETRDEKENLATLFGDMEDLTDEEEVPASQSTENRVLPAPAPRREKTNEELQEELRNLQEQMKALQEQLKVTTIKQTASPARLQKSPVEKSPRPPLKERRVQRIQESTCFSAELDVPALPRTKRVARTPKASPPDPKSSSSRMTSAPSQPLQTISRNKPSGITRGQIVGTPGSSGETTQPICVEAFSGLRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVILKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMKPKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQYKKLSAKRADLQSTFSGGRIPKKFARRGTSLKERLCQDGFYYGGVSSASYAASIAAAVAPKKKIQTTLSNLVVKGTNLIIQETRQKLGIPQKSLSCSEEFKELMDLPTCGARNLKQHLAKATASGIMGSPKPAIKSISASALLKQQKQRMLEMRRRKSEEIQKRFLQSSSEVESPAVPSSSRQPPAQPPRTGSEFPRLEGAPATMTPKLGRGVLEGDDVLFYDESPPPRPKLSALAEAKKLAAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERVEKNTMFSSQAEDELEPARKKRREQLAYLESEEFQKILKAKSKHTGILKEAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRVVTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKCPCGNRSISLDRLPNKHCSNCGLYKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNSLK
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 80 with or without congenital cardiomyopathy (IMD80) [MIM:619313]: An autosomal recessive immunologic disorder with variable manifestations including decreased B and T cells, reduced effector and memory T cells, NK cell deficiency, chronic cytomegalovirus infection. Restrictive cardiomyopathy and hypoplasia of the spleen and thymus have also been reported in some patients. {ECO:0000269|PubMed:32865517}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746, ECO:0000269|PubMed:24726359, ECO:0000269|PubMed:32865517}.
uniprot
proteins
mass_dalton
98183
uniprot
proteins
protein_family
MCM10 family
uniprot
proteins
pubmed
11095689
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11602595
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15136575
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17699597
uniprot
proteins
pubmed
17761813
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608746
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19696745
uniprot
proteins
pubmed
24726359
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
32865517
uniprot
proteins
sequence_length
875
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:32865517}. Note=Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli.
uniprot
proteins