IL11RA
entrez
3590
canonical
uniprot
Q14626
canonical
ensembl
ENSG00000137070
resolver
ensp
ENSP00000394391
resolver
genesymbol
IL11RA
resolver
hgnc
HGNC:5967
resolver
uniprot
Q16542
resolver
uniprot
Q5VZ80
resolver
uniprot
Q7KYJ7
resolver
uniprot_entry
I11RA_HUMAN
resolver
uniprot_sec
Q16542
resolver
uniprot_sec
Q5VZ80
resolver
uniprot_sec
Q7KYJ7
resolver
amino_acid_sequence
MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWFRDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARPVVSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRLLDHRDSVEQVAVLASLGILSFLGLVAGALALGLWLRLRRGGKDGSPKPGFLASVIPVDRRPGAPNL
uniprot
proteins
disease_involvement
DISEASE: Craniosynostosis and dental anomalies (CRSDA) [MIM:614188]: A disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly. {ECO:0000269|PubMed:21741611}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. {ECO:0000269|PubMed:21741611, ECO:0000305}.; FUNCTION: [Soluble interleukin-11 receptor subunit alpha]: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity (PubMed:26876177, PubMed:30279168). The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling (PubMed:26876177, PubMed:30279168). {ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:30279168}.; FUNCTION: [Isoform HCR2]: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity (PubMed:26876177, PubMed:30279168). The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling (PubMed:26876177, PubMed:30279168). {ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:30279168}.
uniprot
proteins
mass_dalton
45222
uniprot
proteins
mutagenesis
MUTAGEN 355; /note="R->E: Decreases proteolyisis by ADAM10."; /evidence="ECO:0000269|PubMed:26876177
uniprot
proteins
post_translational_modification
PTM: A short soluble form is also released from the membrane by proteolysis (PubMed:26876177). The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing (PubMed:26876177). mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3 (PubMed:26876177). {ECO:0000269|PubMed:26876177}.
uniprot
proteins
protein_family
Type 3 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
11141475
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21741611
uniprot
proteins
pubmed
26876177
uniprot
proteins
pubmed
30279168
uniprot
proteins
pubmed
7670098
uniprot
proteins
pubmed
8808281
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Interleukin-11 receptor subunit alpha]: Membrane {ECO:0000269|PubMed:26876177}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Soluble interleukin-11 receptor subunit alpha]: Secreted {ECO:0000269|PubMed:26876177}.; SUBCELLULAR LOCATION: [Isoform HCR2]: Secreted {ECO:0000269|PubMed:26876177}.
uniprot
proteins
transmembrane_region
TRANSMEM 371..391; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins