Cnot6
entrez
287249
canonical
uniprot
Q6AXU9
canonical
ensembl
ENSRNOG00000054891
resolver
ensembl
ENSRNOG00055018479
resolver
ensembl
ENSRNOG00060018615
resolver
ensembl
ENSRNOG00065006026
resolver
ensp
ENSRNOP00000074431
resolver
ensp
ENSRNOP00055025378
resolver
ensp
ENSRNOP00060026094
resolver
ensp
ENSRNOP00065006507
resolver
enst
ENSRNOT00000084509
resolver
enst
ENSRNOT00055031424
resolver
enst
ENSRNOT00060032075
resolver
enst
ENSRNOT00065009118
resolver
genesymbol
Cnot6
resolver
genesymbol_syn
Ccr4
resolver
uniprot_entry
CNOT6_RAT
resolver
amino_acid_sequence
MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSSSLWSLTHLTALHLSDNSLSCIPSDIAKLHNLVYLDLSHNQIQSLPAELGNMVSLRELHLNYNQLRVLPFELGKLFQLQTLSLKGNPLTQDILNLCLEPDGTRRLLNYLLDNLSGTAKRISTEQPPPRSWIMLQEPDRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIISLQEVETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKELIEMSSGKPHLGTEKQLILVANAHMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRSLKSSVLGECGTIPLVLCADLNSLPDSGVVEYLSTGGVETNHKDFKELRYNESLTNFSCNGKNGMTNGRITHGFKLKSAYENGLMPYTNYTFDFKGIIDYIFYSKPQLNTLAILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLELLLPFLPQVNGIHLPGRR
uniprot
proteins
ec_number
3.1.13.4
uniprot
proteins
function
FUNCTION: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000250|UniProtKB:Q9ULM6}.
uniprot
proteins
mass_dalton
63304
uniprot
proteins
protein_family
CCR4/nocturin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
557
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96LI5}. Nucleus {ECO:0000250|UniProtKB:Q96LI5}. Note=Predominantly cytoplasmic. {ECO:0000250|UniProtKB:Q96LI5}.
uniprot
proteins