Spc25
entrez
295661
canonical
uniprot
Q5M856
canonical
ensembl
ENSRNOG00000006731
resolver
ensembl
ENSRNOG00055023600
resolver
ensembl
ENSRNOG00060003048
resolver
ensembl
ENSRNOG00065016382
resolver
ensp
ENSRNOP00000008837
resolver
ensp
ENSRNOP00055032952
resolver
ensp
ENSRNOP00060003668
resolver
ensp
ENSRNOP00065021413
resolver
enst
ENSRNOT00000008837
resolver
enst
ENSRNOT00055040556
resolver
enst
ENSRNOT00060005013
resolver
enst
ENSRNOT00065027268
resolver
genesymbol
Spc25
resolver
genesymbol_syn
Spbc25
resolver
uniprot_entry
SPC25_RAT
resolver
amino_acid_sequence
MGEDELAAFEKSINEFGDKFRYRLSDNRSQVLGLKDAFKDSIRALSEKLSLKLKEEERMAEMILEYKNQLCKQNKLIQEKKDNVLKMIAEVKGKGQEVEVLTANIQDLKEEYARKKETISTANKANEERLKRLQKSADLYRDRLGLEIRKIPGDKLQFIFTSIDPKNPESPFMFSLSINEAKEYEVSDCSPHLECLAEFQEKVRKTNNFSAFLANVRKAFIAKVHN
uniprot
proteins
function
FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. {ECO:0000250|UniProtKB:Q9HBM1}.
uniprot
proteins
mass_dalton
26189
uniprot
proteins
protein_family
SPC25 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9HBM1}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9HBM1}. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. {ECO:0000250|UniProtKB:Q9HBM1}.
uniprot
proteins