H13
entrez
14950
canonical
uniprot
Q9D8V0
canonical
ensembl
ENSMUSG00000019188
resolver
ensp
ENSMUSP00000086460
resolver
ensp
ENSMUSP00000105450
resolver
ensp
ENSMUSP00000120068
resolver
ensp
ENSMUSP00000249563
resolver
ensp
ENSMUSP00000249570
resolver
enst
ENSMUST00000109825
resolver
genesymbol
H13
resolver
genesymbol
Hm13
resolver
genesymbol_syn
H13
resolver
genesymbol_syn
Psl3
resolver
genesymbol_syn
SPP
resolver
uniprot
A3KGS1
resolver
uniprot
F7ABA0
resolver
uniprot
O19444
resolver
uniprot
Q15K37
resolver
uniprot
Q3TXP0
resolver
uniprot
Q542R3
resolver
uniprot
Q6PGJ8
resolver
uniprot
Q811Z6
resolver
uniprot
Q8HWA9
resolver
uniprot
Q8HWB5
resolver
uniprot
Q9CQA4
resolver
uniprot
Q9CSK9
resolver
uniprot_entry
F7ABA0_MOUSE
resolver
uniprot_entry
Q6PGJ8_MOUSE
resolver
uniprot_entry
SPP_MOUSE
resolver
uniprot_sec
A3KGS1
resolver
uniprot_sec
O19444
resolver
uniprot_sec
Q15K37
resolver
uniprot_sec
Q3TXP0
resolver
uniprot_sec
Q542R3
resolver
uniprot_sec
Q811Z6
resolver
uniprot_sec
Q8HWA9
resolver
uniprot_sec
Q8HWB5
resolver
uniprot_sec
Q9CQA4
resolver
uniprot_sec
Q9CSK9
resolver
amino_acid_sequence
MDSAVSDPHNGSAEAGTPANGTTRPPSTPEGIALAYGSLLLMALLPIFFGALRSVRCARGKSSSDMPETITSRDAARFPIIASCTLLGLYLFFKIFSQEYINLLLSMYFFVLGILALSHTISPFMNKFFPANFPNRQYQLLFTQGSGENKEEIINYEFDTKDLVCLGLSSVVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDIFWVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEADNFAMLGLGDIVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALAKGEVAEMFSYEESNPKDPAAETESKEESTEASASKRLEKKEK
uniprot
proteins
ec_number
3.4.23.-
uniprot
proteins
function
FUNCTION: Catalyzes intramembrane proteolysis of signal peptides that have been removed from precursors of secretory and membrane proteins, resulting in the release of the fragment from the ER membrane into the cytoplasm (By similarity). Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (By similarity). May play a role in graft rejection (PubMed:9354467). {ECO:0000250|UniProtKB:Q8TCT9, ECO:0000269|PubMed:9354467}.
uniprot
proteins
mass_dalton
41748
uniprot
proteins
protein_family
Peptidase A22B family
uniprot
proteins
pubmed
11751972
uniprot
proteins
pubmed
12972007
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16730383
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19720873
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9354467
uniprot
proteins
sequence_length
378
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12972007, ECO:0000269|PubMed:16730383}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000250|UniProtKB:Q8TCT9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TCT9}; Lumenal side {ECO:0000250|UniProtKB:Q8TCT9}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:16730383}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 78..98; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 101..121; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 182..202; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 210..230; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 257..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 291..311; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 315..335; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins