FEV
entrez
54738
canonical
uniprot
Q99581
canonical
ensembl
ENSG00000163497
resolver
ensp
ENSP00000295727
resolver
enst
ENST00000295727
resolver
genesymbol
FEV
resolver
genesymbol_syn
PET1
resolver
hgnc
HGNC:18562
resolver
uniprot_entry
FEV_HUMAN
resolver
amino_acid_sequence
MRQSGASQPLLINMYLPDPVGDGLFKDGKNPSWGPLSPAVQKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAAAAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLNLMAASAGVAPAGFSYWPGPGPAATAAAATAALYPSPSLQPPPGPFGAVAAASHLGGHYH
uniprot
proteins
disease_involvement
DISEASE: Sudden infant death syndrome (SIDS) [MIM:272120]: SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. {ECO:0000269|PubMed:17597646}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.; DISEASE: Note=A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity. {ECO:0000269|PubMed:9121764}.
uniprot
proteins
function
FUNCTION: Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. {ECO:0000269|PubMed:12761502}.
uniprot
proteins
mass_dalton
25030
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
12761502
uniprot
proteins
pubmed
15003288
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15986391
uniprot
proteins
pubmed
17172842
uniprot
proteins
pubmed
17597646
uniprot
proteins
pubmed
9121764
uniprot
proteins
sequence_length
238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:12761502}.
uniprot
proteins