TMCC1
entrez
23023
canonical
uniprot
O94876
canonical
ensembl
ENSG00000172765
resolver
ensp
ENSP00000376930
resolver
ensp
ENSP00000389892
resolver
ensp
ENSP00000404711
resolver
ensp
ENSP00000497993
resolver
ensp
ENSP00000513608
resolver
ensp
ENSP00000513609
resolver
ensp
ENSP00000528330
resolver
ensp
ENSP00000528331
resolver
ensp
ENSP00000528332
resolver
ensp
ENSP00000528334
resolver
ensp
ENSP00000625231
resolver
enst
ENST00000426664
resolver
enst
ENST00000432054
resolver
enst
ENST00000648771
resolver
enst
ENST00000698214
resolver
genesymbol
DKFZp686H13261
resolver
genesymbol
TMCC1
resolver
genesymbol_syn
KIAA0779
resolver
hgnc
HGNC:29116
resolver
uniprot
A0A8V8TLJ9
resolver
uniprot
A8K5Y3
resolver
uniprot
B4DE04
resolver
uniprot
E9PC87
resolver
uniprot
F6T4R4
resolver
uniprot
Q68E06
resolver
uniprot
Q6N039
resolver
uniprot
Q8IXM8
resolver
uniprot_entry
A0A8V8TLJ9_HUMAN
resolver
uniprot_entry
E9PC87_HUMAN
resolver
uniprot_entry
F6T4R4_HUMAN
resolver
uniprot_entry
Q6N039_HUMAN
resolver
uniprot_entry
TMCC1_HUMAN
resolver
uniprot_sec
A8K5Y3
resolver
uniprot_sec
B4DE04
resolver
uniprot_sec
Q68E06
resolver
uniprot_sec
Q8IXM8
resolver
amino_acid_sequence
MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQRRRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGTSLHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAAACLPGEEGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFSTLFLVVFIAFLWKHWDALFSYVERFFSSPR
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). {ECO:0000269|PubMed:30220460}.
uniprot
proteins
mass_dalton
72083
uniprot
proteins
protein_family
TEX28 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24454821
uniprot
proteins
pubmed
30220460
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
653
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24454821, ECO:0000269|PubMed:30220460}; Multi-pass membrane protein {ECO:0000255}. Note=Specifically localizes to contact sites between the endoplasmic reticulum and endosomes that are spatially and temporally linked to endosome fission. {ECO:0000269|PubMed:30220460}.
uniprot
proteins
transmembrane_region
TRANSMEM 592..612; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 625..645; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins