Neurod1
entrez
29458
canonical
uniprot
Q64289
canonical
ensembl
ENSRNOG00000005609
resolver
ensembl
ENSRNOG00055021577
resolver
ensembl
ENSRNOG00060014755
resolver
ensembl
ENSRNOG00065023756
resolver
ensp
ENSRNOP00000007662
resolver
ensp
ENSRNOP00000101657
resolver
ensp
ENSRNOP00000108550
resolver
ensp
ENSRNOP00055029971
resolver
ensp
ENSRNOP00060020099
resolver
ensp
ENSRNOP00065033185
resolver
enst
ENSRNOT00000007662
resolver
enst
ENSRNOT00000159286
resolver
enst
ENSRNOT00000162126
resolver
enst
ENSRNOT00055036883
resolver
enst
ENSRNOT00060025223
resolver
enst
ENSRNOT00065040696
resolver
genesymbol
Neurod1
resolver
genesymbol_syn
Neurod
resolver
uniprot
Q569P0
resolver
uniprot_entry
NDF1_RAT
resolver
uniprot_sec
Q569P0
resolver
amino_acid_sequence
MTKSYSESGLMGEPQPQGPPSWTDECLSSQDEEHEADKKEDELEAMNAEEDSLRNGGEEEDEDEDLEEEEEEEEEEDDQKPKRRGPKKKKMTKARLERFKLRRMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNPDMPPHLPTASASFPVHPYSYQSPGLPSPPYGTMDSSHVFHVKPPPHAYSAALEPFFESPLTDCTSPSFDGPLSPPLSINGNFSFKHEPSTEFEKNYAFTMHYPAATLAGPQSHGSIFSSGAAAPRCEIPIDNIMSFDSHSHHERVMSAQLNAIFHD
uniprot
proteins
function
FUNCTION: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3' (By similarity). Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A (By similarity). Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine (By similarity). Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification (By similarity). Also required for dendrite morphogenesis and maintenance in the cerebellar cortex (PubMed:14741104). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q60867, ECO:0000269|PubMed:14741104}.
uniprot
proteins
mass_dalton
40001
uniprot
proteins
mutagenesis
MUTAGEN 259; /note="S->A: No effect on subcellular location."; /evidence="ECO:0000269|PubMed:12297313"; MUTAGEN 262; /note="T->A: No effect on subcellular location."; /evidence="ECO:0000269|PubMed:12297313"; MUTAGEN 266; /note="S->A: No effect on subcellular location."; /evidence="ECO:0000269|PubMed:12297313"; MUTAGEN 274; /note="S->A: Impairs translocation from the cytoplasm to the nucleus upon glucose stimulation."; /evidence="ECO:0000269|PubMed:12297313"; MUTAGEN 274; /note="S->D: No effect on subcellular location."; /evidence="ECO:0000269|PubMed:12297313
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK1; phosphorylation regulates heterodimerization and DNA-binding activities. Phosphorylation on Ser-266 and Ser-274 increases transactivation on the insulin promoter in glucose-stimulated insulinoma cells (By similarity). Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-336 by CaMK2; which promotes dendritic growth. {ECO:0000250, ECO:0000269|PubMed:12297313, ECO:0000269|PubMed:14741104}.
uniprot
proteins
pubmed
10101232
uniprot
proteins
pubmed
12297313
uniprot
proteins
pubmed
14741104
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20554861
uniprot
proteins
pubmed
8660336
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12297313}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:12297313}. Note=Colocalizes with NR0B2 in the nucleus (By similarity). In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation. {ECO:0000250}.
uniprot
proteins