Spr
entrez
29270
canonical
uniprot
P18297
canonical
ensembl
ENSRNOG00000015455
resolver
ensembl
ENSRNOG00055012862
resolver
ensembl
ENSRNOG00060024409
resolver
ensembl
ENSRNOG00065016616
resolver
ensp
ENSRNOP00000020749
resolver
ensp
ENSRNOP00055017847
resolver
ensp
ENSRNOP00060035093
resolver
ensp
ENSRNOP00065021806
resolver
enst
ENSRNOT00000020749
resolver
enst
ENSRNOT00055022005
resolver
enst
ENSRNOT00060042333
resolver
enst
ENSRNOT00065027685
resolver
genesymbol
Spr
resolver
uniprot
B2RYK3
resolver
uniprot_entry
B2RYK3_RAT
resolver
uniprot_entry
SPRE_RAT
resolver
amino_acid_sequence
MEGGRLGCAVCVLTGASRGFGRALAPQLAGLLSPGSVLLLSARSDSMLRQLKEELCTQQPGLQVVLAAADLGTESGVQQLLSAVRELPRPERLQRLLLINNAGTLGDVSKGFLNINDLAEVNNYWALNLTSMLCLTTGTLNAFSNSPGLSKTVVNISSLCALQPFKGWGLYCAGKAARDMLYQVLAVEEPSVRVLSYAPGPLDTNMQQLARETSMDPELRSRLQKLNSEGELVDCGTSAQKLLSLLQRDTFQSGAHVDFYDI
uniprot
proteins
ec_number
1.1.1.153
uniprot
proteins
function
FUNCTION: Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
uniprot
proteins
mass_dalton
28128
uniprot
proteins
mutagenesis
MUTAGEN 29; /note="A->V: Reduces affinity for NADP and for sepiapterin 4-fold."; /evidence="ECO:0000269|PubMed:10350607"; MUTAGEN 46; /note="S->A: Abolishes phosphorylation by CaMK2. No effect on kinetic parameters; when associated with A-196 and A-214."; /evidence="ECO:0000269|PubMed:11825621"; MUTAGEN 158; /note="S->D: Reduces activity 4-fold. Loss of activity; when associated with V-171."; /evidence="ECO:0000269|PubMed:10350607"; MUTAGEN 171; /note="Y->V: Reduces activity 4-fold. Loss of activity; when associated with V-171."; /evidence="ECO:0000269|PubMed:10350607"; MUTAGEN 175; /note="K->I: Reduces activity 4-fold."; /evidence="ECO:0000269|PubMed:10350607"; MUTAGEN 196; /note="S->A: Abolishes phosphorylation by CaMK2. No effect on kinetic parameters; when associated with A-46 and A-214."; /evidence="ECO:0000269|PubMed:11825621"; MUTAGEN 214; /note="S->A: Abolishes phosphorylation by CaMK2. No effect on kinetic parameters; when associated with A-46 and A-196."; /evidence="ECO:0000269|PubMed:11825621
uniprot
proteins
post_translational_modification
PTM: In vitro phosphorylation of Ser-46, Ser-196 and Ser-214 by CaMK2 does not change kinetic parameters. {ECO:0000269|PubMed:11825621}.
uniprot
proteins
protein_family
Sepiapterin reductase family
uniprot
proteins
pubmed
10350607
uniprot
proteins
pubmed
11825621
uniprot
proteins
pubmed
2201030
uniprot
proteins
pubmed
2260974
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins