Shc1
entrez
20416
canonical
uniprot
P98083
canonical
ensembl
ENSMUSG00000042626
resolver
ensp
ENSMUSP00000035361
resolver
ensp
ENSMUSP00000091940
resolver
genesymbol
Shc1
resolver
genesymbol_syn
Shc
resolver
genesymbol_syn
ShcA
resolver
uniprot
Q3U2Q7
resolver
uniprot
Q8BFY3
resolver
uniprot
Q8K4C6
resolver
uniprot
Q8K4C7
resolver
uniprot_entry
SHC1_MOUSE
resolver
uniprot_sec
Q3U2Q7
resolver
uniprot_sec
Q8BFY3
resolver
uniprot_sec
Q8K4C6
resolver
uniprot_sec
Q8K4C7
resolver
amino_acid_sequence
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCSFFPRMSNLKLANPAGGRLGPKGEPGKAAEDGEGSAGAALRDSGLLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAARPTLPSAQMSSHLGATLPIGQHAAGDHEVRKQMLPPPPCPGRELFDDPSYVNIQNLDKARQAGGGAGPPNPSLNGSAPRDLFDMKPFEDALRVPPPPQSMSMAEQLQGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVDRKV
uniprot
proteins
function
FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p47Shc and isoform p52Shc, once phosphorylated, couple activated receptor kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p47Shc and isoform p52 may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span. Involved in the oncostatin-M-mediated signaling pathway through type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) where it contributes to activation of the Ras/Raf/MAPK pathway through JAK1-dependent recruitment to OSMR subunit of OSMR complex and SHC1 association with GRB2 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P29353, ECO:0000269|PubMed:12571362, ECO:0000269|PubMed:17272725}.
uniprot
proteins
mass_dalton
62608
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in response to FLT4 signaling (By similarity). Tyrosine phosphorylated by ligand-activated PDGFRB (By similarity). May be tyrosine phosphorylated by activated PTK2/FAK1 (By similarity). Tyrosine phosphorylated by TEK/TIE2 (By similarity). Tyrosine phosphorylated by activated PTK2B/PYK2 (By similarity). Dephosphorylation by PTPN2 may regulate interaction with GRB2 (By similarity). Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to KIT signaling. Isoform p47Shc and isoform p52Shc are phosphorylated on tyrosine residues of the Pro-rich domain. Isoform p66Shc is phosphorylated on Ser-36 by PRKCB upon treatment with insulin, hydrogen peroxide or irradiation with ultraviolet light. FLT3 signaling promotes tyrosine phosphorylation of isoform p47Shc and isoform p52Shc. Also tyrosine phosphorylated by ligand-activated ALK. {ECO:0000250, ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:9165038}.; PTM: Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to FLT4 and KIT signaling. Isoform p46Shc and isoform p52Shc are phosphorylated on tyrosine residues of the Pro-rich domain. Isoform p66Shc is phosphorylated on Ser-36 by PRKCB upon treatment with insulin, hydrogen peroxide or irradiation with ultraviolet light (By similarity). Tyrosine phosphorylated in response to FLT3 signaling (By similarity). Tyrosine phosphorylated by activated PTK2B/PYK2 (By similarity). Tyrosine phosphorylated by ligand-activated ALK. Tyrosine phosphorylated by ligand-activated PDGFRB. Tyrosine phosphorylated by TEK/TIE2. May be tyrosine phosphorylated by activated PTK2/FAK1; tyrosine phosphorylation was seen in an astrocytoma biopsy, where PTK2/FAK1 kinase activity is high, but not in normal brain tissue. Isoform p52Shc dephosphorylation by PTPN2 may regulate interaction with GRB2 (By similarity). Oncostatin-M-mediated signaling pathway induces phosphorylation at tyrosine residues by JAK1 leading to its activation and allows, concomitantly, SHC1 recruitment to OSMR subunit of OSMR complex and SHC1 association with GRB2 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P29353}.
uniprot
proteins
pubmed
10068665
uniprot
proteins
pubmed
10080542
uniprot
proteins
pubmed
10395202
uniprot
proteins
pubmed
11433297
uniprot
proteins
pubmed
11948181
uniprot
proteins
pubmed
12367511
uniprot
proteins
pubmed
12571362
uniprot
proteins
pubmed
12925710
uniprot
proteins
pubmed
15467833
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17272725
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19665990
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7798194
uniprot
proteins
pubmed
8643691
uniprot
proteins
pubmed
8654924
uniprot
proteins
pubmed
9083021
uniprot
proteins
pubmed
9099679
uniprot
proteins
pubmed
9165038
uniprot
proteins
pubmed
9885561
uniprot
proteins
sequence_length
579
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P29353}.; SUBCELLULAR LOCATION: [Isoform p47Shc]: Mitochondrion matrix {ECO:0000250}. Note=Targeting of isoform p47Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform p66Shc]: Mitochondrion {ECO:0000269|PubMed:17272725}. Note=In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation.
uniprot
proteins