Slc38a1
entrez
105727
canonical
uniprot
Q8K2P7
canonical
ensembl
ENSMUSG00000023169
resolver
ensp
ENSMUSP00000085799
resolver
ensp
ENSMUSP00000085801
resolver
ensp
ENSMUSP00000097833
resolver
ensp
ENSMUSP00000175278
resolver
ensp
ENSMUSP00000175279
resolver
ensp
ENSMUSP00000175283
resolver
ensp
ENSMUSP00000175286
resolver
ensp
ENSMUSP00000175298
resolver
genesymbol
Slc38a1
resolver
genesymbol_syn
Nat2
resolver
genesymbol_syn
Snat1
resolver
uniprot
Q3TNM1
resolver
uniprot
Q3TQ53
resolver
uniprot
Q6NXZ2
resolver
uniprot
Q8BHI3
resolver
uniprot
Q8BXE2
resolver
uniprot
Q99PR1
resolver
uniprot_entry
S38A1_MOUSE
resolver
uniprot_sec
Q3TNM1
resolver
uniprot_sec
Q3TQ53
resolver
uniprot_sec
Q6NXZ2
resolver
uniprot_sec
Q8BHI3
resolver
uniprot_sec
Q8BXE2
resolver
uniprot_sec
Q99PR1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by alpha-(methylamino)isobutyric acid (MeAIB). Inhibited by lithium, potassium, choline ions, N-methylglucamine. The pH dependence has an allosteric effect on the transport. {ECO:0000250|UniProtKB:Q9JM15}.
uniprot
proteins
amino_acid_sequence
MMHFKSGLELTELQNMTVPEDDNVSNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKRKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLILLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKLVIFGATSLQNTGAMLSYLFIVKNELPSAIKSLMGEEDAFSAWYVDGRVLVVMVTFGIILPLCLLKNLGYLGYTSGFSLSCMMFFLIVVIYKKFQTPCMSVEQNSTVSANVTDACTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYEKVQSDLLHKYQSTGDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFHLCRHVLVTIILLIIINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITNQDGDKGTQRIWAALFLGLGVLFSLISIPLVIYDWACSSGTDEGH
uniprot
proteins
function
FUNCTION: Symporter that cotransports short-chain neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:11325958, PubMed:17179157, PubMed:27655909, PubMed:32668809). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:11325958). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (PubMed:31050701, PubMed:32668809). May also contributes to amino acid transport in placental trophoblast (By similarity). Regulates synaptic plasticity (PubMed:31050701). {ECO:0000250|UniProtKB:Q9H2H9, ECO:0000269|PubMed:11325958, ECO:0000269|PubMed:17179157, ECO:0000269|PubMed:27655909, ECO:0000269|PubMed:31050701, ECO:0000269|PubMed:32668809}.
uniprot
proteins
mass_dalton
53795
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="N->Q: Does not affect N-glycosylation. Does not affect cell membrane localization."; /evidence="ECO:0000269|PubMed:27655909"; MUTAGEN 251; /note="N->Q: Affects N-glycosylation. Abolishes Nglycosylation; when associated with Q-257 and Q-310. Does not affect cell membrane localization. Abolishes L-glutamine transport activity; when associated with Q-257."; /evidence="ECO:0000269|PubMed:27655909"; MUTAGEN 257; /note="N->Q: Affects N-glycosylation. Abolishes Nglycosylation; when associated with Q-251 and Q-310. Does not affect cell membrane localization. Abolishes L-glutamine transport activity; when associated with Q-251."; /evidence="ECO:0000269|PubMed:27655909"; MUTAGEN 310; /note="N->Q: Does not affect N-glycosylation. Abolishes Nglycosylation; when associated with Q-251 and Q-257. Does not affect cell membrane localization."; /evidence="ECO:0000269|PubMed:27655909
uniprot
proteins
post_translational_modification
PTM: N-glycosylation plays an important role in the L-glutamine transport. {ECO:0000269|PubMed:27655909}.
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
pubmed
11325958
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17179157
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27655909
uniprot
proteins
pubmed
31050701
uniprot
proteins
pubmed
32668809
uniprot
proteins
sequence_length
485
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27655909}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JM15}. Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain. {ECO:0000250|UniProtKB:Q9JM15}.
uniprot
proteins
transmembrane_region
TRANSMEM 75..97; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 149..169; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 189..211; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 274..294; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 349..369; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 392..412; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 415..435; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 451..471; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins