Kcnj11
entrez
16514
canonical
uniprot
Q61743
canonical
ensembl
ENSMUSG00000096146
resolver
ensp
ENSMUSP00000136002
resolver
ensp
ENSMUSP00000147439
resolver
enst
ENSMUST00000211674
resolver
genesymbol
Kcnj11
resolver
uniprot
Q9QX21
resolver
uniprot_entry
KCJ11_MOUSE
resolver
uniprot_sec
Q9QX21
resolver
activity_regulation
ACTIVITY REGULATION: KATP channels are regulated by cytoplasmic ATP/ADP ratios; ATP inhibits the channel by closing the pore, while ADP activates the channel. Activated by phosphatidylinositol 4,5-biphosphate (PtdIns(4,5)P2). {ECO:0000250|UniProtKB:Q14654}.
uniprot
proteins
amino_acid_sequence
MLSRKGIIPEEYVLTRLAEDPAEPRYRTRERRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMVWWLIAFAHGDLAPGEGTNVPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVITLRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNGIFLVAPLIIYHVIDSNSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDRSLLDALTLASSRGPLRKRSVAVAKAKPKFSISPDSLS
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channel that forms the pore of ATP-sensitive potassium channels (KATP), regulating potassium permeability as a function of cytoplasmic ATP and ADP concentrations in many different cells (By similarity). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). In pancreatic cells, it forms KATP channels with ABCC8/SUR1 (By similarity). Can form cardiac and smooth muscle-type KATP channels with ABCC9 (By similarity). {ECO:0000250|UniProtKB:Q14654}.
uniprot
proteins
mass_dalton
43562
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity. {ECO:0000250}.
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ11 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7502040
uniprot
proteins
pubmed
8549751
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q14654}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q14654}.
uniprot
proteins
transmembrane_region
TRANSMEM 66..92; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:Q14654"; TRANSMEM 143..171; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:Q14654
uniprot
proteins