Neurod2
entrez
54276
canonical
uniprot
Q63689
canonical
ensembl
ENSRNOG00000028417
resolver
ensp
ENSRNOP00000089812
resolver
ensp
ENSRNOP00000111755
resolver
enst
ENSRNOT00000038833
resolver
enst
ENSRNOT00000123149
resolver
genesymbol
Neurod2
resolver
uniprot
A0A8I6A9H9
resolver
uniprot_entry
A0A8I6A9H9_RAT
resolver
uniprot_entry
NDF2_RAT
resolver
amino_acid_sequence
MLTRLFSEPGLLSDVPKFASWGDGDDDEPRSDKGDAPPQPPPAPGSGAPGPARATKPVSLRGEEVPEPTLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSKLRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYPYPCSRLAGDQCQAAGGLGGGAAHALRTHGYCAAYETLYAAAGGGGASPDYNSSEYEGPLSPPLCLNGNFSLKQDSSPDHEKSYHYSMHYSALPGSRPAGHGLVFGSSAVRGGVHSENLLSYDMHLHHDRGPMYEELNAFFHN
uniprot
proteins
function
FUNCTION: Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
41466
uniprot
proteins
pubmed
20346398
uniprot
proteins
pubmed
8605021
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
uniprot
proteins