Atl1
entrez
362750
canonical
uniprot
Q6PST4
canonical
ensembl
ENSRNOG00000005063
resolver
ensembl
ENSRNOG00055008958
resolver
ensembl
ENSRNOG00060006290
resolver
ensembl
ENSRNOG00065006820
resolver
ensp
ENSRNOP00000041993
resolver
ensp
ENSRNOP00000084485
resolver
ensp
ENSRNOP00055012094
resolver
ensp
ENSRNOP00060007691
resolver
ensp
ENSRNOP00065007840
resolver
enst
ENSRNOT00000046085
resolver
enst
ENSRNOT00000116837
resolver
enst
ENSRNOT00055015133
resolver
enst
ENSRNOT00060010341
resolver
enst
ENSRNOT00065010620
resolver
genesymbol
Atl1
resolver
genesymbol_syn
Spg3a
resolver
uniprot
A0A8I6GAH6
resolver
uniprot_entry
A0A8I6GAH6_RAT
resolver
uniprot_entry
ATLA1_RAT
resolver
amino_acid_sequence
MAKSRRDRNSWGGFSEKSSDWSSEEEEPVRKAGPVQVLIVKDDHSFELDEAALNRILLSEAVRDKEVVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIWSEVFLINKLDGKKVAVLLMDTQGTFDSQSTLRDSATVFALSTMISSIQVYNLSQNVQEDDLQHLQLFTEYGRLAMEETFLKPFQSLIFLVRDWSFPYEFSYGADGGAKFLEKRLKVSGNQHEELQNVRKHIHSCFTNISCFLLPHPGLKVATNPNFDGKLKEIDDEFIKNLKILIPWLLSPESLDIKEINGNKITCRGLLEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEDSVKLFRGVKKMGGEEFSRRYLQQLESEIDELYIQYIKHNDSKNIFHAARTPATLFVVIFITYVIAGVTGFIGLDIIASLCNMIMGLTLITLCTWAYIRYSGEYRELGAVIDQVAAALWDQGSTNEALYKLYSAAATHRHLYQQAFPAPKSEPTEQPEKKKI
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Atlastin-1 (ATL1) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (PubMed:16537571). Two atlastin-1 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity). May also regulate more or less directly Golgi biogenesis (PubMed:16537571). Indirectly regulates axonal development (PubMed:16537571). {ECO:0000250|UniProtKB:Q8WXF7, ECO:0000269|PubMed:16537571}.
uniprot
proteins
mass_dalton
63375
uniprot
proteins
mutagenesis
MUTAGEN 217; /note="R->Q: Loss of GTPase activity. No effect on oligomerization."; /evidence="ECO:0000269|PubMed:16537571"; MUTAGEN 239; /note="R->C: Loss of GTPase activity. No effect on oligomerization."; /evidence="ECO:0000269|PubMed:16537571"; MUTAGEN 258; /note="H->R: Loss of GTPase activity. No effect on oligomerization."; /evidence="ECO:0000269|PubMed:16537571
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation, by different kinases, of the N-terminal hypervariable region (HVR) regulates the ATL1-mediated membrane tethering step. {ECO:0000250|UniProtKB:Q8WXF7}.
uniprot
proteins
protein_family
GB1 subfamily
uniprot
proteins
protein_family
GB1/RHD3 GTPase family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
14506257
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16537571
uniprot
proteins
pubmed
19665976
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24262037
uniprot
proteins
sequence_length
558
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14506257}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8WXF7}. Golgi apparatus membrane {ECO:0000269|PubMed:14506257}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8WXF7}. Cell projection, axon {ECO:0000269|PubMed:16537571}. Note=Localizes to endoplasmic reticulum tubular network. {ECO:0000269|PubMed:14506257}.
uniprot
proteins
transmembrane_region
TRANSMEM 450..470; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 472..492; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins