POLDIP3
entrez
84271
canonical
uniprot
Q9BY77
canonical
ensembl
ENSG00000100227
resolver
ensp
ENSP00000252115
resolver
ensp
ENSP00000252116
resolver
ensp
ENSP00000397927
resolver
ensp
ENSP00000668378
resolver
enst
ENST00000451060
resolver
genesymbol
POLDIP3
resolver
genesymbol_syn
KIAA1649
resolver
genesymbol_syn
PDIP46
resolver
hgnc
HGNC:23782
resolver
uniprot
A8K6F8
resolver
uniprot
A8K6V9
resolver
uniprot
B4E0L0
resolver
uniprot
F6VRR5
resolver
uniprot
Q009A7
resolver
uniprot
Q5H972
resolver
uniprot
Q6PGN6
resolver
uniprot
Q7Z6Z0
resolver
uniprot
Q9NSP5
resolver
uniprot
Q9NSP6
resolver
uniprot_entry
B4E0L0_HUMAN
resolver
uniprot_entry
F6VRR5_HUMAN
resolver
uniprot_entry
PDIP3_HUMAN
resolver
uniprot_sec
A8K6F8
resolver
uniprot_sec
A8K6V9
resolver
uniprot_sec
Q009A7
resolver
uniprot_sec
Q5H972
resolver
uniprot_sec
Q6PGN6
resolver
uniprot_sec
Q7Z6Z0
resolver
uniprot_sec
Q9NSP5
resolver
uniprot_sec
Q9NSP6
resolver
amino_acid_sequence
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGKVQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQVPQQKAMAPLHPHPAGMRINVVNNHQAKQNLYDLDEDDDGIASVPTKQMKFAASGGFLHHMAGLSSSKLSMSKALPLTKVVQNDAYTAPALPSSIRTKALTNMSRTLVNKEEPPKELPAAEPVLSPLEGTKMTVNNLHPRVTEEDIVELFCVCGALKRARLVHPGVAEVVFVKKDDAITAYKKYNNRCLDGQPMKCNLHMNGNVITSDQPILLRLSDSPSMKKESELPRRVNSASSSNPPAEVDPDTILKALFKSSGASVTTQPTEFKIKL
uniprot
proteins
function
FUNCTION: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}.
uniprot
proteins
mass_dalton
46089
uniprot
proteins
mutagenesis
MUTAGEN 383; /note="S->A: Reduces in vitro phosphorylation by RPS6KB1. Abolishes in vitro phosphorylation by RPS6KB1; when associated with A-385."; /evidence="ECO:0000269|PubMed:15341740"; MUTAGEN 385; /note="S->A: Reduces in vitro phosphorylation by RPS6KB1. Reduces in vitro phosphorylation by RPS6KB1; when associated with A-383."; /evidence="ECO:0000269|PubMed:15341740
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-383 and Ser-385 by RPS6KB1. {ECO:0000269|PubMed:15341740}.
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11258795
uniprot
proteins
pubmed
12522211
uniprot
proteins
pubmed
12529303
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15341740
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16984396
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18423201
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20844015
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22928037
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein.
uniprot
proteins