Gpr88
entrez
64378
canonical
uniprot
Q9EPB7
canonical
ensembl
ENSMUSG00000068696
resolver
ensp
ENSMUSP00000087959
resolver
ensp
ENSMUSP00000183567
resolver
ensp
ENSMUSP00000183569
resolver
enst
ENSMUST00000090473
resolver
genesymbol
Gpr88
resolver
genesymbol_syn
Strg
resolver
uniprot
B2RXU4
resolver
uniprot_entry
B2RXU4_MOUSE
resolver
uniprot_entry
GPR88_MOUSE
resolver
amino_acid_sequence
MTNSSSTSTSTTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPSGSAEPPGDWDGGGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQVLYQRRHTVGMLALSWALALGLVLLLPPWAPKPGAEPPQVHYPALLAAGALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPAAPHAPGPGGAAHPAQPQPLPAALQPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAAAATAVPAMSQAQLGTRAAGQHW
uniprot
proteins
function
FUNCTION: Orphan G protein-coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing (By similarity). May play a role in the regulation of cognitive and motor function (PubMed:26188600). Couples with the heterotrimeric G protein complex of the G(i) subfamily, consisting of GNAI1, GNB1 and GNG2, thereby acting through a G(i)-mediated pathway (By similarity). Plays a role in the attenuation of D1 dopamine receptor (D1R)-mediated cAMP response in ciliated cells (By similarity). In on-ciliated cells, involved in the inhibition of the beta-2 adrenergic receptor (B2AR) response (By similarity). {ECO:0000250|UniProtKB:Q9ESP4, ECO:0000250|UniProtKB:Q9GZN0, ECO:0000269|PubMed:26188600}.
uniprot
proteins
mass_dalton
40240
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11056049
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26188600
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9ESP4}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q9GZN0}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9ESP4}. Nucleus {ECO:0000250|UniProtKB:Q9ESP4}. Note=Localized to cilia in ciliated cells; whereas in non-ciliated cells, distributed throughout the cell membrane (By similarity). During cortical lamination, subcellular location shifts, on the day of birth, from expression at the plasma membrane and in the cytoplasm to the nuclei of neurons. This intranuclear localization remains throughout adulthood. {ECO:0000250|UniProtKB:Q9ESP4, ECO:0000250|UniProtKB:Q9GZN0}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 74..94; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 117..136; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 159..179; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 286..306; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins