Tnks1bp1
entrez
228140
canonical
uniprot
P58871
canonical
ensembl
ENSMUSG00000033955
resolver
ensp
ENSMUSP00000045767
resolver
ensp
ENSMUSP00000107232
resolver
enst
ENSMUST00000111605
resolver
genesymbol
Tnks1bp1
resolver
genesymbol_syn
Kiaa1741
resolver
genesymbol_syn
Tab182
resolver
uniprot
A2BH84
resolver
uniprot
Q6ZPI8
resolver
uniprot_entry
TB182_MOUSE
resolver
uniprot_sec
A2BH84
resolver
uniprot_sec
Q6ZPI8
resolver
amino_acid_sequence
MKGSTLREGTAMASPLPQDMEEELAPVGSEPGDPRAKPPVKPKPRGLPSKPALPAKPSLLVPVGPRPPRGPLAELPSARKMNMLAGPQPYGVSKRPLPFAPRPSAEATAGGDVTQESGKEDAGKEDLPPLTPPARCAALGGVRKAPAPFRPSSERFAACTVEEILAKMEQPRKEILASPDRLWGSRLTFNHDGSSRYGPRTYGAPCPREEDSKSPAKGRSQEGTAEIPAECQEEHSKTPEERNLTSSPAMNGDLAKLACSEAPTDVSKTWVTSSADPVSEHGGSTSAVRLANISVPASESPRLSSRPSSPCHSQLSETQSPAASEASSICLPVTPASPSAVLPAEPPGHSPSSELPAEAAPETLSPNSSPVETVSGHHSPEQPPVLLPQLLTEGAELPDITRTFPCGEEAAARGHTESRPSSLAQRRFSEGVLQPPSQDQEKLGGSLATLPQGQGSQSALDRPFGSGTESNWSLSQSFEWTFPTRPSGLGVWRLDSPPPSPITEASEAAEAAEADSWAVSGRGEGVSQVGPGTPPAPESPRKPISGVQGNDPGISLPQRDDGESQPRSPALLPSTVEGPPGAPLLQAKENYEDQEPLVGHESPITLAAREAALPVLEPALGQQQPTPSDQPCILFVDVPDPEQALSTEEDVVTLGWAETTLPMTEAQEPCSVSPEPTGPESSSRWLDDLLASPPPNSGSARRAAGAELKDRQSPSTCSEGLLGWAQKDLQSEFGVATDSHHSSFGSSSWSQDTSQNYSLGGRSPVGDTGLGKRDWSSKCGQGSGEGSTREWASRHSLGQEVIGIGGSQDESEVPVRERAVGRPAQLGAQGLEADAQQWEFGKRESQDPHSIHDKELQDQEFGKRDSLGSFSTRDASLQDWEFGKRASVSTNQDTDENDQELGMKNLSRGYSSQDAEEQDREFEKRDSVLDIHGSRATAQQNQEFGKSAWFQDYSSGGGGSRVLGSQERGFGIRSLSSGFSPEEAQQQDEEFEKKTPVGEDRFCEASRDVGHLEEGASGGLLSPSTPHSRDGAARPKDEGSWQDGDSSQEITRLQGRMQAESQSPTNVDLEDKEREQRGWAGEFSLGVAAQSEAAFSPGRQDWSRDVCVEASESSYQFGIIGNDRVSGAGLSPSRKSGGGHFVPPGETKAGAVDWTDQLGLRNLEVSSCVSSEGPSEARENVVGQMGWSDSLGLNNGDLARRLGTGESEEPRSLGVGEKDWTSSVEARNRDLPGQAEVGRHSQARESGVGEPDWSGAEAGEFLKSRERGVGQADWTPDLGLRNMAPGAGCSPGEPRELGVGQVDWGDDLGLRNLEVSCDLESGGSRGCGVGQMDWAQDLGLRNLRLCGAPSEVRECGVGRVGPDLELDPKSSGSLSPGLETEDPLEARELGVGEISGPETQGEDSSSPSFETPSEDTGMDTGEAPSLGASPSSCLTRSPPSGSQSLLEGIMTASSSKGAPQRESAASGSRVLLEEEGLAAGAGQGEPQEPSRAPLPSSRPQPDGEASQVEEVDGTWSLTGAARQNEQASAPPPRRPPRGLLPSCPSEDFSFIEDTEILDSAMYRSRANLGRKRGHRAPAIRPGGTLGLSETADSDTRLFQDSTEPRASRVPSSDEEVVEEPQSRRTRMSLGTKGLKVNLFPGLSPSALKAKLRSRNRSAEEGEVTESKSSQKESSVQRSKSCKVPGLGKPLTLPPKPEKSSGSEGSSPNWLQALKLKKKKI
uniprot
proteins
function
FUNCTION: Component of the CCR4-NOT complex, a large multiprotein complex with several proteins assembled around the scaffolding protein CNOT1. This complex is one of the major cellular mRNA deadenylase and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. CNOT12 affects helicase selection into the CCR4-NOT complex. In addition, plays a role in DNA double strand break repair and is involved in actin cytoskeleton rearrangement and cancer cell invasion. {ECO:0000250|UniProtKB:Q9C0C2}.
uniprot
proteins
mass_dalton
181825
uniprot
proteins
post_translational_modification
PTM: Highly phosphorylated by ATM or ATR in response to ionizing radiation-induced DNA damage. {ECO:0000250|UniProtKB:Q9C0C2}.
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1720
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9C0C2}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9C0C2}. Chromosome {ECO:0000250|UniProtKB:Q9C0C2}. Note=Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin. {ECO:0000250|UniProtKB:Q9C0C2}.
uniprot
proteins