NLRC3
entrez
197358
canonical
uniprot
Q7RTR2
canonical
ensembl
ENSG00000167984
resolver
ensp
ENSP00000352039
resolver
genesymbol
NLRC3
resolver
genesymbol_syn
NOD3
resolver
hgnc
HGNC:29889
resolver
uniprot
C3VPR7
resolver
uniprot
Q5EY36
resolver
uniprot
Q8NF48
resolver
uniprot
Q8NI01
resolver
uniprot
Q8NI02
resolver
uniprot
Q8TEL3
resolver
uniprot_entry
C3VPR7_HUMAN
resolver
uniprot_entry
NLRC3_HUMAN
resolver
uniprot_sec
Q5EY36
resolver
uniprot_sec
Q8NF48
resolver
uniprot_sec
Q8NI01
resolver
uniprot_sec
Q8NI02
resolver
uniprot_sec
Q8TEL3
resolver
amino_acid_sequence
MRKQEVRTGREAGQGHGTGSPAEQVKALMDLLAGKGSQGSQAPQALDRTPDAPLGPCSNDSRIQRHRKALLSKVGGGPELGGPWHRLASLLLVEGLTDLQLREHDFTQVEATRGGGHPARTVALDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFRDLNTHEKLCADRLICSVFPHVGEPSLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIRGFNEEEIKVCLEQMFPEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDLALLQGAPCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQAYRTQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM
uniprot
proteins
function
FUNCTION: Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed:22863753). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (PubMed:25277106). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (PubMed:25277106). {ECO:0000250|UniProtKB:Q5DU56, ECO:0000269|PubMed:15705585, ECO:0000269|PubMed:22863753, ECO:0000269|PubMed:25277106}.
uniprot
proteins
mass_dalton
114658
uniprot
proteins
mutagenesis
MUTAGEN 457..460; /note="SLQE->AAAA: Strong decrease of TRAF6-binding."; /evidence="ECO:0000269|PubMed:22863753"; MUTAGEN 582..585; /note="SVEE->AAAA: Almost no effect on TRAF6-binding."; /evidence="ECO:0000269|PubMed:22863753
uniprot
proteins
protein_family
NLRP family
uniprot
proteins
pubmed
12693554
uniprot
proteins
pubmed
12766759
uniprot
proteins
pubmed
15705585
uniprot
proteins
pubmed
22863753
uniprot
proteins
pubmed
24560620
uniprot
proteins
pubmed
25277106
uniprot
proteins
sequence_length
1065
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15705585, ECO:0000269|PubMed:24560620, ECO:0000269|PubMed:25277106}.
uniprot
proteins