SCT
entrez
6343
canonical
uniprot
P09683
canonical
ensembl
ENSG00000070031
resolver
ensembl
ENSG00000274473
resolver
ensp
ENSP00000176195
resolver
ensp
ENSP00000483559
resolver
enst
ENST00000176195
resolver
enst
ENST00000622382
resolver
genesymbol
SCT
resolver
hgnc
HGNC:10607
resolver
uniprot_entry
SECR_HUMAN
resolver
amino_acid_sequence
MAPRPLLLLLLLLGGSAARPAPPRARRHSDGTFTSELSRLREGARLQRLLQGLVGKRSEQDAENSMAWTRLSAGLLCPSGSNMPILQAWMPLDGTWSPWLPPGPMVSEPAGAAAEGTLRPR
uniprot
proteins
function
FUNCTION: Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:25332973). Exerts its biological effects by binding to secretin receptor (SCTR), a G protein-coupled receptor expressed in the basolateral domain of several cells (PubMed:25332973, PubMed:33008599, PubMed:32811827). Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content (By similarity). Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation (Probable). Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation (By similarity). Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity). {ECO:0000250|UniProtKB:P11384, ECO:0000250|UniProtKB:Q08535, ECO:0000269|PubMed:32811827, ECO:0000269|PubMed:33008599, ECO:0000303|PubMed:25332973, ECO:0000305|PubMed:30449620}.
uniprot
proteins
mass_dalton
13016
uniprot
proteins
protein_family
Glucagon family
uniprot
proteins
pubmed
11060443
uniprot
proteins
pubmed
25332973
uniprot
proteins
pubmed
30449620
uniprot
proteins
pubmed
32811827
uniprot
proteins
pubmed
33008599
uniprot
proteins
sequence_length
121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.2}.
uniprot
proteins