Sppl3
entrez
74585
canonical
uniprot
Q9CUS9
canonical
ensembl
ENSMUSG00000029550
resolver
ensp
ENSMUSP00000031530
resolver
enst
ENSMUST00000031530
resolver
genesymbol
Sppl3
resolver
genesymbol_syn
Imp2
resolver
genesymbol_syn
Psl4
resolver
genesymbol_syn
Usmg3
resolver
uniprot
E9QP88
resolver
uniprot
Q8R597
resolver
uniprot_entry
SPPL3_MOUSE
resolver
uniprot_sec
E9QP88
resolver
uniprot_sec
Q8R597
resolver
activity_regulation
ACTIVITY REGULATION: Its proteolytic activity is blocked by a signal peptide peptidase (SPP) inhibitor, (ZLL)2-ketone (ZLL) or a gamma-secretase inhibitor, LY411,575. {ECO:0000250|UniProtKB:Q8TCT6}.
uniprot
proteins
amino_acid_sequence
MAEQTYSWAYSLVDSSQVSTFLISILLIVYGSFRSLNMDFENQDKEKDSNSSSGSFNGNSTNNSIQTIDSTQALFLPIGASVSLLVMFFFFDSVQVVFTICTAVLATIAFAFLLLPMCQYLTRPCSPQNKISFGCCGRFTAAELLSFSLSVMLVLIWVLTGHWLLMDALAMGLCVAMIAFVRLPSLKVSCLLLSGLLIYDVFWVFFSAYIFNSNVMVKVATQPADNPLDVLSRKLHLGPNVGRDVPRLSLPGKLVFPSSTGSHFSMLGIGDIVMPGLLLCFVLRYDNYKKQASGDSCGAPGPANISGRMQKVSYFHCTLIGYFVGLLTATVASRIHRAAQPALLYLVPFTLLPLLTMAYLKGDLRRMWSEPFHSKSSSSRFLEV
uniprot
proteins
ec_number
3.4.23.-
uniprot
proteins
function
FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries. Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971). {ECO:0000269|PubMed:25354954, ECO:0000269|PubMed:25384971, ECO:0000269|PubMed:25827571}.
uniprot
proteins
mass_dalton
42261
uniprot
proteins
mutagenesis
MUTAGEN 200; /note="D->A: Does not inhibit NFAT-induced transcription activation."; /evidence="ECO:0000269|PubMed:25384971"; MUTAGEN 271; /note="D->A: Does not inhibit NFAT-induced transcription activation."; /evidence="ECO:0000269|PubMed:25384971
uniprot
proteins
post_translational_modification
PTM: Not glycosylated. {ECO:0000250|UniProtKB:Q8TCT6}.
uniprot
proteins
protein_family
Peptidase A22B family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20562862
uniprot
proteins
pubmed
25354954
uniprot
proteins
pubmed
25384971
uniprot
proteins
pubmed
25827571
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8TCT6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TCT6}. Golgi apparatus {ECO:0000250|UniProtKB:Q8TCT6}. Membrane {ECO:0000250|UniProtKB:Q8TCT6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TCT6}; Lumenal side {ECO:0000250|UniProtKB:Q8TCT6}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 74..94; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 96..116; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 191..211; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 263..283; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 312..332; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 340..360; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins