Gpr4
entrez
308408
canonical
uniprot
Q4KLH9
canonical
ensembl
ENSRNOG00000016362
resolver
ensembl
ENSRNOG00055032895
resolver
ensembl
ENSRNOG00060032917
resolver
ensembl
ENSRNOG00065034006
resolver
ensp
ENSRNOP00000021894
resolver
ensp
ENSRNOP00000101552
resolver
ensp
ENSRNOP00000107787
resolver
ensp
ENSRNOP00055047005
resolver
ensp
ENSRNOP00060047153
resolver
ensp
ENSRNOP00065048044
resolver
enst
ENSRNOT00000021893
resolver
enst
ENSRNOT00000141286
resolver
enst
ENSRNOT00000153217
resolver
enst
ENSRNOT00055056906
resolver
enst
ENSRNOT00060057073
resolver
enst
ENSRNOT00065058395
resolver
genesymbol
Gpr4
resolver
uniprot_entry
GPR4_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by a network of residues that connects an extracellular-facing cavity to Glu-147, a conserved charged residue buried in the transmembrane core of the receptor. Protonation likely drives conformational changes in extracellular loop 2 (ECL2), which stabilizes movement of transmembrane 3 (TM3) and a series of rearrangements that connect the extracellular-facing cavity to Glu-147, a residue only conserved in proton-sensing G protein-coupled receptors. {ECO:0000250|UniProtKB:P46093}.
uniprot
proteins
amino_acid_sequence
MDNSTGTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVRQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYSNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMERWVAWMNLYRVFVGFLFPWALMLLCYRGILRAVQSSVSTERQEKVKIKRLALSLIAIVLVCFAPYHALLLSRSAVYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASNKPQEMANASLTLETPLTSKRSTTGKTSGAVWAVPPTAQGDQVPLKVLLPPAQ
uniprot
proteins
function
FUNCTION: Proton-sensing G protein-coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions. Activated by an optimal pH of 6.8-7.2. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. GPR4 is mainly coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. May also couple with G(i), G(q) and G(12)/G(13) G proteins (By similarity). Acts as a key regulator of respiratory sensitivity to CO2/H(+) in brain retrotrapezoid nucleus neurons: acts by mediating detection of protons generated by the formation of carbonic acid in the blood, an important mechanism to impulse to breathe (By similarity). Also acts as a regulator of acid secretion in the kidney collecting duct by maintaining acid-base homeostasis in the kidney. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells, possibly through the G(12)/G(13)/Rho GTPase signaling pathway (By similarity). {ECO:0000250|UniProtKB:P46093, ECO:0000250|UniProtKB:Q8BUD0}.
uniprot
proteins
mass_dalton
41267
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P46093}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..47; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P46093"; TRANSMEM 52..82; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P46093"; TRANSMEM 88..123; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P46093"; TRANSMEM 132..158; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P46093"; TRANSMEM 175..212; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P46093"; TRANSMEM 217..252; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P46093"; TRANSMEM 263..291; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P46093
uniprot
proteins