Bcas3
entrez
192197
canonical
uniprot
Q8CCN5
canonical
ensembl
ENSMUSG00000059439
resolver
ensp
ENSMUSP00000074416
resolver
ensp
ENSMUSP00000090496
resolver
ensp
ENSMUSP00000103696
resolver
ensp
ENSMUSP00000103697
resolver
ensp
ENSMUSP00000182865
resolver
enst
ENSMUST00000092821
resolver
enst
ENSMUST00000108061
resolver
enst
ENSMUST00000108062
resolver
genesymbol
Bcas3
resolver
uniprot
B1AR74
resolver
uniprot
F7BD97
resolver
uniprot
Q0VF62
resolver
uniprot
Q8CC16
resolver
uniprot
Q9EPX3
resolver
uniprot_entry
B1AR74_MOUSE
resolver
uniprot_entry
BCAS3_MOUSE
resolver
uniprot_entry
F7BD97_MOUSE
resolver
uniprot_entry
Q0VF62_MOUSE
resolver
uniprot_sec
Q8CC16
resolver
uniprot_sec
Q9EPX3
resolver
amino_acid_sequence
MNETMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVVPQAYSGSPLTEEKEKIVWVRFENADLNDTSRNLEFHELHSTGNEPPLLVMIGYSDGMQVWGIPISGEAQELFSVRHGPVRAARILPAPQLGAQKCDNFAEKRPLLGVCKSIGSSGTTPPYCCVDLYSLRTGEMVKSIQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFFVTSCYPCPGPNMNPIALGSRWLAYAENKLIRCHQSRGGACGDNIQSYTATVLSAAKTLKSGLTMVGKVVTQLTGTLPSGVTEDDVALHCNSRRSPLVPGIITVIDTETVGEGQVLVSEDSDSDGIVAHFPAHEKPVCCMAFNTSGMLLVTTDTLGHDFHVFQILTHPWSSSQCAVHHLYTLHRGETEAKVQDICFSHDCRWVVVSTLRGTSHVFPINPYGGQPCVRTHMSPRVVNRMSRFQKSAGLEEIEQELTSKQGGRCSPVPGLSSSPSGSPLHGKLTSQDSYNNFTNNNPGNPRLSPLPSLMVVTPLAQIKQPMTLGTITKRTGPYLFGAGCFSIKAPCKVKSPPQISPSKSMGGEFCVAAVFGTSRSWFANNAGLKREKDQSKQVVVESLYIISCYGTLVEHMIEPRPISTAPKISDDTPLEIMTSPRASWTLVRTPQWNELQPPFNANHPLLLAAEAVQYYQLLLAGSLPPGSPGPITRHGSYDSLASDHSGQEDEEWLSQVEIVTHTGPHRRLWMGPQFHFKTIQTSGQTTVISTSSSVLQSHGPSDTPQPLLDFDTDDLDLNSLRIQPVRSDPVSMPGSSRAVSDRRGVSTVTDAASGTFDRSVTLLEVCGSWPEGFGLRHMSSMEHSEEGLRERLADAMAESPSRDVVGSGTELQREGSIETLSNSSGSTSGSIPRNFDGYRSPLPTNESQPLSLFPTGFP
uniprot
proteins
function
FUNCTION: Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin (By similarity). Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy. Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (By similarity). {ECO:0000250|UniProtKB:Q9H6U6, ECO:0000269|PubMed:22300583}.
uniprot
proteins
mass_dalton
101021
uniprot
proteins
protein_family
BCAS3 family
uniprot
proteins
pubmed
16099728
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16617102
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17505058
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22300583
uniprot
proteins
sequence_length
928
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H6U6}. Cytoplasm {ECO:0000269|PubMed:16099728, ECO:0000269|PubMed:22300583}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22300583}. Preautophagosomal structure {ECO:0000250|UniProtKB:Q9H6U6}. Note=Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner (By similarity). Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells. The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner (By similarity). {ECO:0000250|UniProtKB:Q9H6U6, ECO:0000269|PubMed:22300583}.
uniprot
proteins