CCR1
entrez
1230
canonical
uniprot
P32246
canonical
ensembl
ENSG00000163823
resolver
ensp
ENSP00000296140
resolver
ensp
ENSP00000573458
resolver
ensp
ENSP00000573459
resolver
ensp
ENSP00000614275
resolver
ensp
ENSP00000614276
resolver
enst
ENST00000296140
resolver
enst
ENST00000903399
resolver
enst
ENST00000903400
resolver
enst
ENST00000944216
resolver
enst
ENST00000944217
resolver
genesymbol
CCR1
resolver
genesymbol_syn
CMKBR1
resolver
genesymbol_syn
CMKR1
resolver
genesymbol_syn
SCYAR1
resolver
hgnc
HGNC:1602
resolver
uniprot
A0A024R2P9
resolver
uniprot
Q5U003
resolver
uniprot
Q86VA9
resolver
uniprot_entry
CCR1_HUMAN
resolver
uniprot_entry
Q5U003_HUMAN
resolver
uniprot_sec
A0A024R2P9
resolver
uniprot_sec
Q86VA9
resolver
amino_acid_sequence
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
uniprot
proteins
function
FUNCTION: Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed:14991608). Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine (PubMed:15905581, PubMed:38417634). For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF and leukotriene B4 (By similarity). Also mediates monocyte migration upon CXCL4 binding (PubMed:29930254). Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway (By similarity). {ECO:0000250|UniProtKB:P51675, ECO:0000269|PubMed:14991608, ECO:0000269|PubMed:15905581, ECO:0000269|PubMed:29930254, ECO:0000269|PubMed:38417634}.
uniprot
proteins
mass_dalton
41173
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14991608
uniprot
proteins
pubmed
15001559
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15905581
uniprot
proteins
pubmed
18587271
uniprot
proteins
pubmed
29930254
uniprot
proteins
pubmed
34949837
uniprot
proteins
pubmed
38417634
uniprot
proteins
pubmed
7505609
uniprot
proteins
pubmed
7679328
uniprot
proteins
pubmed
7683036
uniprot
proteins
pubmed
9287217
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18587271}; Multi-pass membrane protein {ECO:0000269|PubMed:18587271}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..60; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 65..91; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 108..129; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 147..171; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 198..223; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 240..264; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 282..305; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins