LIMK2
entrez
3985
canonical
uniprot
P53671
canonical
ensembl
ENSG00000182541
resolver
ensp
ENSP00000330470
resolver
ensp
ENSP00000332687
resolver
ensp
ENSP00000339916
resolver
genesymbol
LIMK2
resolver
hgnc
HGNC:6614
resolver
uniprot
A8K6H5
resolver
uniprot
Q7KZ80
resolver
uniprot
Q7L3H5
resolver
uniprot
Q96E10
resolver
uniprot
Q99464
resolver
uniprot
Q9UFU0
resolver
uniprot_entry
LIMK2_HUMAN
resolver
uniprot_sec
A8K6H5
resolver
uniprot_sec
Q7KZ80
resolver
uniprot_sec
Q7L3H5
resolver
uniprot_sec
Q96E10
resolver
uniprot_sec
Q99464
resolver
uniprot_sec
Q9UFU0
resolver
amino_acid_sequence
MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:8537403}.
uniprot
proteins
mass_dalton
72232
uniprot
proteins
mutagenesis
MUTAGEN 451; /note="D->A: Abrogates kinase activity."; /evidence="ECO:0000269|PubMed:22328514"; MUTAGEN 505; /note="T->E: Phosphomimetic mutant; enhances kinase activity."; /evidence="ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:22328514"; MUTAGEN 505; /note="T->V: Abolishes cofilin phosphorylation and enhancement of stress fiber formation."; /evidence="ECO:0000269|PubMed:11018042
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and/or threonine residues by ROCK1. {ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11340065}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
10436159
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11018042
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11340065
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
22328514
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25849865
uniprot
proteins
pubmed
8537403
uniprot
proteins
pubmed
8954941
uniprot
proteins
sequence_length
638
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:22328514}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:25849865}.; SUBCELLULAR LOCATION: [Isoform LIMK2a]: Cytoplasm {ECO:0000269|PubMed:8954941}. Nucleus {ECO:0000269|PubMed:8954941}.; SUBCELLULAR LOCATION: [Isoform LIMK2b]: Cytoplasm {ECO:0000269|PubMed:8954941}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:8954941}. Nucleus {ECO:0000269|PubMed:8954941}. Note=Mainly present in the cytoplasm and is scarcely translocated to the nucleus. {ECO:0000269|PubMed:8954941}.
uniprot
proteins