PRDX6
entrez
9588
canonical
uniprot
P30041
canonical
ensembl
ENSG00000117592
resolver
ensp
ENSP00000342026
resolver
ensp
ENSP00000537986
resolver
enst
ENST00000340385
resolver
enst
ENST00000867927
resolver
genesymbol
HEL-S-128m
resolver
genesymbol
PRDX6
resolver
genesymbol_syn
AOP2
resolver
genesymbol_syn
KIAA0106
resolver
hgnc
HGNC:16753
resolver
uniprot
A0A024R938
resolver
uniprot
A8JZY7
resolver
uniprot
P32077
resolver
uniprot
Q5TAH4
resolver
uniprot
Q5ZEZ8
resolver
uniprot
V9HWC7
resolver
uniprot_entry
PRDX6_HUMAN
resolver
uniprot_entry
V9HWC7_HUMAN
resolver
uniprot_sec
A0A024R938
resolver
uniprot_sec
A8JZY7
resolver
uniprot_sec
P32077
resolver
uniprot_sec
Q5TAH4
resolver
uniprot_sec
Q5ZEZ8
resolver
activity_regulation
ACTIVITY REGULATION: MJ33 or lithium;[(2R)-1-hexadecoxy-3-(2,2,2-trifluoroethoxy)propan-2-yl] methyl phosphate inhibits its phospholipase A2 activity (PubMed:26830860). CI-976 or 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide inhibits its lysophosphatidylcholine acyltransferase activity (PubMed:26830860). {ECO:0000269|PubMed:26830860}.
uniprot
proteins
amino_acid_sequence
MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
uniprot
proteins
ec_number
1.11.1.27
uniprot
proteins
ec_number
2.3.1.23
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10893423, PubMed:9497358). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10893423). Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10893423, PubMed:26830860). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (PubMed:10893423). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (PubMed:10893423). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (PubMed:26830860). {ECO:0000269|PubMed:10893423, ECO:0000269|PubMed:26830860, ECO:0000269|PubMed:9497358}.
uniprot
proteins
mass_dalton
25035
uniprot
proteins
mutagenesis
MUTAGEN 32; /note="S->A: Loss of phospholipase activity, but no effect on peroxidase activity."; /evidence="ECO:0000269|PubMed:9497358"; MUTAGEN 47; /note="C->S: Loss of peroxidase activity, but no effect on phospholipase activity."; /evidence="ECO:0000269|PubMed:9497358
uniprot
proteins
post_translational_modification
PTM: Irreversibly inactivated by overoxidation of Cys-47 to sulfinic acid (Cys-SO(2)H) and sulfonic acid (Cys-SO(3)H) forms upon oxidative stress. {ECO:0000269|PubMed:12059788, ECO:0000269|PubMed:27353378}.; PTM: Phosphorylation at Thr-177 by MAP kinases increases the phospholipase activity of the enzyme (By similarity). The phosphorylated form exhibits a greater lysophosphatidylcholine acyltransferase activity compared to the non-phosphorylated form (PubMed:26830860). {ECO:0000250|UniProtKB:O35244, ECO:0000269|PubMed:26830860}.
uniprot
proteins
protein_family
Peroxiredoxin family
uniprot
proteins
protein_family
Prx6 subfamily
uniprot
proteins
pubmed
10893423
uniprot
proteins
pubmed
12059788
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
1286669
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16186110
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19188445
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20716133
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26830860
uniprot
proteins
pubmed
27353378
uniprot
proteins
pubmed
7788527
uniprot
proteins
pubmed
8313871
uniprot
proteins
pubmed
8999971
uniprot
proteins
pubmed
9050990
uniprot
proteins
pubmed
9497358
uniprot
proteins
pubmed
9587003
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16186110, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:9497358}. Lysosome {ECO:0000250|UniProtKB:O35244}. Note=Also found in lung secretory organelles (lamellar bodies). {ECO:0000250|UniProtKB:O35244}.
uniprot
proteins