MZB1
entrez
51237
canonical
uniprot
Q8WU39
canonical
ensembl
ENSG00000170476
resolver
ensp
ENSP00000303920
resolver
genesymbol
MZB1
resolver
genesymbol_syn
MEDA7
resolver
genesymbol_syn
PACAP
resolver
hgnc
HGNC:30125
resolver
uniprot
B3KQ72
resolver
uniprot
D2IYS0
resolver
uniprot
Q7Z6N2
resolver
uniprot
Q96RL5
resolver
uniprot
Q9P0T3
resolver
uniprot_entry
B3KQ72_HUMAN
resolver
uniprot_entry
MZB1_HUMAN
resolver
uniprot_sec
D2IYS0
resolver
uniprot_sec
Q7Z6N2
resolver
uniprot_sec
Q96RL5
resolver
uniprot_sec
Q9P0T3
resolver
amino_acid_sequence
MRLSLPLLLLLLGAWAIPGGLGDRAPLTATAPQLDDEEMYSAHMPAHLRCDACRAVAYQMWQNLAKAETKLHTSNSGGRRELSELVYTDVLDRSCSRNWQDYGVREVDQVKRLTGPGLSEGPEPSISVMVTGGPWPTRLSRTCLHYLGEFGEDQIYEAHQQGRGALEALLCGGPQGACSEKVSATREEL
uniprot
proteins
function
FUNCTION: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. {ECO:0000250, ECO:0000269|PubMed:11350957, ECO:0000269|PubMed:21688198}.; FUNCTION: Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.
uniprot
proteins
mass_dalton
20694
uniprot
proteins
mutagenesis
MUTAGEN 50; /note="C->S: Does not affect activity."; /evidence="ECO:0000269|PubMed:19805157"; MUTAGEN 53; /note="C->S: No significant activity."; /evidence="ECO:0000269|PubMed:19805157"; MUTAGEN 95; /note="C->S: No significant activity."; /evidence="ECO:0000269|PubMed:19805157"; MUTAGEN 143; /note="C->S: No significant activity."; /evidence="ECO:0000269|PubMed:19805157"; MUTAGEN 171; /note="C->S: No significant activity."; /evidence="ECO:0000269|PubMed:19805157"; MUTAGEN 178; /note="C->S: Does not affect activity."; /evidence="ECO:0000269|PubMed:19805157
uniprot
proteins
post_translational_modification
PTM: Forms an interchain disulfide bond with IgM monomers. {ECO:0000250}.
uniprot
proteins
protein_family
MZB1 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11350957
uniprot
proteins
pubmed
12792799
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19805157
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21688198
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum lumen {ECO:0000269|PubMed:19805157}. Secreted {ECO:0000269|PubMed:21688198}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:11350957}. Note=Diffuse granular localization in the cytoplasm surrounding the nucleus (PubMed:11350957).
uniprot
proteins