PRELID1
entrez
27166
canonical
uniprot
Q9Y255
canonical
ensembl
ENSG00000169230
resolver
ensp
ENSP00000302114
resolver
ensp
ENSP00000427097
resolver
genesymbol
PRELID1
resolver
genesymbol_syn
PRELI
resolver
hgnc
HGNC:30255
resolver
uniprot
B2R5F7
resolver
uniprot
D6RD25
resolver
uniprot
Q549N2
resolver
uniprot
Q9UI13
resolver
uniprot
Q9UJS9
resolver
uniprot_entry
PRLD1_HUMAN
resolver
uniprot_sec
B2R5F7
resolver
uniprot_sec
D6RD25
resolver
uniprot_sec
Q549N2
resolver
uniprot_sec
Q9UI13
resolver
uniprot_sec
Q9UJS9
resolver
amino_acid_sequence
MVKYFLGQSVLRSSWDQVFAAFWQRYPNPYSKHVLTEDIVHREVTPDQKLLSRRLLTKTNRMPRWAERLFPANVAHSVYVLEDSIVDPQNQTMTTFTWNINHARLMVVEERCVYCVNSDNSGWTEIRREAWVSSSLFGVSRAVQEFGLARFKSNVTKTMKGFEYILAKLQGEAPSKTLVETAKEAKEKAKETALAATEKAKDLASKAATKKQQQQQQFV
uniprot
proteins
function
FUNCTION: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs. {ECO:0000269|PubMed:18945965, ECO:0000269|PubMed:21364629, ECO:0000269|PubMed:23931759}.
uniprot
proteins
mass_dalton
25181
uniprot
proteins
pubmed
10784606
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
14640972
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18945965
uniprot
proteins
pubmed
21364629
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23931759
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion intermembrane space {ECO:0000269|PubMed:14640972, ECO:0000269|PubMed:18945965, ECO:0000269|PubMed:21364629, ECO:0000269|PubMed:23931759}.
uniprot
proteins