HTRA3
entrez
94031
canonical
uniprot
P83110
canonical
ensembl
ENSG00000170801
resolver
ensp
ENSP00000303766
resolver
ensp
ENSP00000371952
resolver
ensp
ENSP00000788326
resolver
genesymbol
HTRA3
resolver
genesymbol_syn
PRSP
resolver
hgnc
HGNC:30406
resolver
uniprot
Q7Z7A2
resolver
uniprot_entry
HTRA3_HUMAN
resolver
uniprot_sec
Q7Z7A2
resolver
amino_acid_sequence
MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724). {ECO:0000250|UniProtKB:Q9D236, ECO:0000269|PubMed:21321049, ECO:0000269|PubMed:22229724}.
uniprot
proteins
mass_dalton
48608
uniprot
proteins
mutagenesis
MUTAGEN 305; /note="S->A: Abolishes protease activity. Stabilizes the protein."; /evidence="ECO:0000269|PubMed:22229724
uniprot
proteins
protein_family
Peptidase S1C family
uniprot
proteins
pubmed
12513693
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16650464
uniprot
proteins
pubmed
17962403
uniprot
proteins
pubmed
19424634
uniprot
proteins
pubmed
21321049
uniprot
proteins
pubmed
22229724
uniprot
proteins
pubmed
26110759
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21321049}. Note=Secretion increased during decidualization of endometrial stromal cells.
uniprot
proteins