Cbx2
entrez
12416
canonical
uniprot
P30658
canonical
ensembl
ENSMUSG00000025577
resolver
ensp
ENSMUSP00000026662
resolver
ensp
ENSMUSP00000273871
resolver
enst
ENSMUST00000026662
resolver
genesymbol
Cbx2
resolver
genesymbol_syn
M33
resolver
uniprot
A2ABG2
resolver
uniprot
O35731
resolver
uniprot
Q3URA3
resolver
uniprot
Q8CIA0
resolver
uniprot_entry
CBX2_MOUSE
resolver
uniprot_entry
Q3URA3_MOUSE
resolver
uniprot_sec
A2ABG2
resolver
uniprot_sec
O35731
resolver
uniprot_sec
Q8CIA0
resolver
amino_acid_sequence
MEELSSVGEQVFAAECILSKRLRKGKLEYLVKWRGWSSKHNSWEPEENILDPRLLLAFQKKEHEKEVQNRKRGKRPRGRPRKHTVTSSCSRRSKLKEPDAPSKSKSSSSSSSSTSSSSSSDEEEDDSDLDSKRGPRGRETHPVPQKKAQILVAKPELKDPIRKKRGRKPLPPEQKAARRPVSLAKVLKTTRKDLGTSAAKLPPPLSAPVAGLAALKAHTKEACGGPSTMATPENLASLMKGMAGSPSRGGIWQSSIVHYMNRMSQSQVQAASRLALKAQATNKCGLGLDLKVRTQKGGELGGSPAGGKVPKAPGGGAAEQQRGNHSGSPGAQLAPTQELSLQVLDLQSVKNGVPGVGLLARHAPAKAIPATNPATGKGPGSGPTGANMTNAPTDNNKGEKLTCKATALPAPSVKRDTVKSVAASGGQEGHTAPGEGRKPPALSELSTGEENSSSDSDPDSTSLPSAAQNLSVAIQTSQDWKPTRSLIEHVFVTDVTANLITVTVKESPTSVGFFNLRHY
uniprot
proteins
function
FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (By similarity). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (PubMed:16537902). Plays a role in the lineage differentiation of the germ layers in embryonic development (PubMed:22226355). Involved in sexual development, acting as activator of NR5A1 expression (By similarity). {ECO:0000250|UniProtKB:Q14781, ECO:0000269|PubMed:16537902, ECO:0000269|PubMed:22226355}.
uniprot
proteins
mass_dalton
54918
uniprot
proteins
pubmed
1352241
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16537902
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22226355
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
9312051
uniprot
proteins
sequence_length
519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:9312051}. Chromosome {ECO:0000269|PubMed:16537902}. Note=Localizes to the inactivated X chromosome in females. {ECO:0000269|PubMed:16537902}.
uniprot
proteins