Fcer1a
entrez
14125
canonical
uniprot
P20489
canonical
ensembl
ENSMUSG00000005339
resolver
ensp
ENSMUSP00000056882
resolver
enst
ENSMUST00000049706
resolver
genesymbol
Fcer1a
resolver
genesymbol_syn
Fce1a
resolver
uniprot
E9QLR4
resolver
uniprot_entry
FCERA_MOUSE
resolver
uniprot_sec
E9QLR4
resolver
amino_acid_sequence
MVTGRSAQLCLALLFMSLDVILTATEKSVLTLDPPWIRIFTGEKVTLSCYGNNHLQMNSTTKWIHNGTVSEVNSSHLVIVSATVQDSGKYICQKQGLFKSKPVYLNVTQDWLLLQTSADMVLVHGSFDIRCHGWKNWNVRKVIYYRNDHAFNYSYESPVSIREATLNDSGTYHCKGYLRQVKYESDKFRIAVVKAYKCKYYWLQLIFPLLVAILFAVDTGLLLSTEEQFKSVLEIQKTGKYKKVETELLT
uniprot
proteins
function
FUNCTION: High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions. {ECO:0000250|UniProtKB:P12319}.
uniprot
proteins
mass_dalton
28657
uniprot
proteins
pubmed
17728245
uniprot
proteins
pubmed
1839735
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
2527850
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P12319}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P12319}.
uniprot
proteins
transmembrane_region
TRANSMEM 205..223; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins