Pdcl3
entrez
316348
canonical
uniprot
Q4KLJ8
canonical
ensembl
ENSRNOG00000013286
resolver
ensp
ENSRNOP00000017882
resolver
enst
ENSRNOT00000017882
resolver
genesymbol
Pdcl3
resolver
uniprot_entry
PDCL3_RAT
resolver
amino_acid_sequence
MQDPNADTEWNDILRKKGILPPKESLKELEEEEEGKEEQRLQQSVVKTYEDMTLEELQENEDEFSEEDERAIEMYRQQRLAEWKATQLRNKFGEVLEISGKDYVQEVTKAGEGLWVVLHLYKQGIPLCSLINHHLSGLARKFPDVKFIKAISTTCIPNYPDRNLPTVFVYREGDIKAQFIGPLVFGGMNLTIDELEWKLSESGAIKTELEENPKKAIKDVLLSSVRDPVPMRRDSDSEDD
uniprot
proteins
function
FUNCTION: Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (By similarity). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (PubMed:27496612). Modulates the activation of caspases during apoptosis (By similarity). {ECO:0000250|UniProtKB:Q9H2J4, ECO:0000269|PubMed:27496612}.
uniprot
proteins
mass_dalton
27699
uniprot
proteins
post_translational_modification
PTM: N-terminal methionine acetylation destabilizes the protein. {ECO:0000250|UniProtKB:Q9H2J4}.
uniprot
proteins
protein_family
Phosducin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
27496612
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H2J4}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9H2J4}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9H2J4}.
uniprot
proteins