CYP2D6
entrez
1565
canonical
uniprot
P10635
canonical
ensembl
ENSG00000100197
resolver
ensembl
ENSG00000275211
resolver
ensp
ENSP00000351927
resolver
ensp
ENSP00000483677
resolver
ensp
ENSP00000496150
resolver
enst
ENST00000612990
resolver
genesymbol
CYP2D6
resolver
genesymbol_syn
CYP2DL1
resolver
hgnc
HGNC:2625
resolver
uniprot
C1ID52
resolver
uniprot
Q16752
resolver
uniprot
Q2XND6
resolver
uniprot
Q2XND7
resolver
uniprot
Q2XNE0
resolver
uniprot
Q5Y7H2
resolver
uniprot
Q6B012
resolver
uniprot
Q6NXU8
resolver
uniprot_entry
C1ID52_HUMAN
resolver
uniprot_entry
CP2D6_HUMAN
resolver
uniprot_entry
Q5Y7H2_HUMAN
resolver
uniprot_sec
Q16752
resolver
uniprot_sec
Q2XND6
resolver
uniprot_sec
Q2XND7
resolver
uniprot_sec
Q2XNE0
resolver
uniprot_sec
Q6B012
resolver
uniprot_sec
Q6NXU8
resolver
amino_acid_sequence
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
uniprot
proteins
ec_number
1.14.14.-
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:19965576, PubMed:20972997). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:18698000, PubMed:21289075). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid (PubMed:10681376). Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:16352597, ECO:0000269|PubMed:18698000, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20972997, ECO:0000269|PubMed:21289075, ECO:0000269|PubMed:21576599}.
uniprot
proteins
mass_dalton
55769
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000269|PubMed:10681376}.; PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20972997}.; PATHWAY: Steroid metabolism; cholesterol metabolism. {ECO:0000269|PubMed:21576599}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10064570
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10681376
uniprot
proteins
pubmed
15469410
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15768052
uniprot
proteins
pubmed
16352597
uniprot
proteins
pubmed
1844820
uniprot
proteins
pubmed
18698000
uniprot
proteins
pubmed
19965576
uniprot
proteins
pubmed
20972997
uniprot
proteins
pubmed
21289075
uniprot
proteins
pubmed
21576599
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25469868
uniprot
proteins
pubmed
2574001
uniprot
proteins
pubmed
3123997
uniprot
proteins
pubmed
3410476
uniprot
proteins
pubmed
7845481
uniprot
proteins
pubmed
7868129
uniprot
proteins
pubmed
8287064
uniprot
proteins
pubmed
8655150
uniprot
proteins
pubmed
8971426
uniprot
proteins
pubmed
9241659
uniprot
proteins
sequence_length
497
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:21576599}; Peripheral membrane protein.
uniprot
proteins