Nsmf
entrez
56876
canonical
uniprot
Q99NF2
canonical
ensembl
ENSMUSG00000006476
resolver
ensp
ENSMUSP00000006646
resolver
ensp
ENSMUSP00000074022
resolver
ensp
ENSMUSP00000097908
resolver
ensp
ENSMUSP00000099995
resolver
ensp
ENSMUSP00000110028
resolver
ensp
ENSMUSP00000110030
resolver
ensp
ENSMUSP00000325101
resolver
ensp
ENSMUSP00000325106
resolver
ensp
ENSMUSP00000325107
resolver
ensp
ENSMUSP00000325109
resolver
ensp
ENSMUSP00000325111
resolver
ensp
ENSMUSP00000325114
resolver
ensp
ENSMUSP00000325117
resolver
ensp
ENSMUSP00000325141
resolver
enst
ENSMUST00000074422
resolver
enst
ENSMUST00000114386
resolver
enst
ENSMUST00000114388
resolver
genesymbol
Nsmf
resolver
genesymbol_syn
Jac
resolver
genesymbol_syn
Nelf
resolver
uniprot
A2AJ92
resolver
uniprot
A2AJ93
resolver
uniprot
A2AJ94
resolver
uniprot
A2AJ95
resolver
uniprot
A2AJ96
resolver
uniprot
Q3TNG2
resolver
uniprot
Q3TY90
resolver
uniprot
Q8BPT0
resolver
uniprot
Q8C9R5
resolver
uniprot
Q9DBF4
resolver
uniprot
Q9ERZ1
resolver
uniprot_entry
A2AJ92_MOUSE
resolver
uniprot_entry
A2AJ95_MOUSE
resolver
uniprot_entry
A2AJ96_MOUSE
resolver
uniprot_entry
NSMF_MOUSE
resolver
uniprot_entry
Q3TNG2_MOUSE
resolver
uniprot_entry
Q3TY90_MOUSE
resolver
uniprot_sec
A2AJ93
resolver
uniprot_sec
A2AJ94
resolver
uniprot_sec
Q8BPT0
resolver
uniprot_sec
Q8C9R5
resolver
uniprot_sec
Q9DBF4
resolver
uniprot_sec
Q9ERZ1
resolver
amino_acid_sequence
MGAAASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGADHLLADAYSGHDGSPEMQPAPQNKRRLSLVSNGRYEGSISDEAVSGKPAIEGPQPHVYTISREPALLPGSEAEAIELAVVKGRRQRERHPHHHSQPLRASPGSSREDISRPCQSWAGSRQGSKECPGCAQLVPGPSSRAFGLEQPPLPEAPGRHKKLERMYSVDGVSDDVPIRTWFPKENLFSFQTATTTMQAISVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLDEACEDLDWDTEKGLEAMACNTEGFLPPKVMLISSKVPKAEYIPTIIRRDDPSIIPILYDHEHATFEDILEEIEKKLNIYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHIMGCYILGNPNGEKLFQNLRTLMTPYKVTFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFDDVL
uniprot
proteins
function
FUNCTION: Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. {ECO:0000269|PubMed:10898796}.
uniprot
proteins
mass_dalton
60293
uniprot
proteins
post_translational_modification
PTM: Proteolytically processed after NMDA receptor activation. Cleaved in a calcium-dependent and calpain-sensitive manner. Calpain cleavage is essential for the translocation process from dendrites to the nucleus (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
NSMF family
uniprot
proteins
pubmed
10898796
uniprot
proteins
pubmed
15018815
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20025934
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
532
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Nucleus envelope {ECO:0000250}. Nucleus membrane {ECO:0000250}. Nucleus matrix {ECO:0000250}. Cytoplasm. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane; Peripheral membrane protein. Cell projection, dendrite {ECO:0000250}. Synapse {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Postsynaptic density {ECO:0000250}. Membrane {ECO:0000250}. Note=Found on the outside of the luteinizing-hormone-releasing hormone (LHRH) cell membrane and axons projecting from the olfactory pit and epithelium. Associates with transcriptionally active chromatin regions. Detected at the nuclear membranes of CA1 neurons. Cortical cytoskeleton. Localized in proximal apical dendrites. Colocalizes with CABP1 in dendrites and dendritic spines. Myristoylation is a prerequisite for extranuclear localization. Translocates from dendrites to the nucleus during NMDA receptor-dependent long-term potentiation (LTP) induction of synaptic transmission at Schaffer collateral/CA1 synapses of hippocampal primary neurons and in an importin-dependent manner (By similarity). {ECO:0000250}.
uniprot
proteins