DBNL
entrez
28988
canonical
uniprot
Q9UJU6
canonical
ensembl
ENSG00000136279
resolver
ensp
ENSP00000411701
resolver
ensp
ENSP00000415173
resolver
ensp
ENSP00000417653
resolver
ensp
ENSP00000417749
resolver
ensp
ENSP00000419992
resolver
ensp
ENSP00000584563
resolver
genesymbol
DBNL
resolver
genesymbol_syn
CMAP
resolver
genesymbol_syn
SH3P7
resolver
hgnc
HGNC:2696
resolver
uniprot
A4D2I9
resolver
uniprot
B4DDP6
resolver
uniprot
B4DEM2
resolver
uniprot
B4DUF9
resolver
uniprot
C9J7P1
resolver
uniprot
P84070
resolver
uniprot
Q6IAI8
resolver
uniprot
Q96F30
resolver
uniprot
Q96K74
resolver
uniprot
Q9HBN8
resolver
uniprot
Q9NR72
resolver
uniprot_entry
B4DUF9_HUMAN
resolver
uniprot_entry
DBNL_HUMAN
resolver
uniprot_sec
A4D2I9
resolver
uniprot_sec
B4DDP6
resolver
uniprot_sec
B4DEM2
resolver
uniprot_sec
C9J7P1
resolver
uniprot_sec
P84070
resolver
uniprot_sec
Q6IAI8
resolver
uniprot_sec
Q96F30
resolver
uniprot_sec
Q96K74
resolver
uniprot_sec
Q9HBN8
resolver
uniprot_sec
Q9NR72
resolver
amino_acid_sequence
MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
uniprot
proteins
function
FUNCTION: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}.
uniprot
proteins
mass_dalton
48207
uniprot
proteins
mutagenesis
MUTAGEN 361; /note="D->A: Abolishes cleavage by caspase-3."; /evidence="ECO:0000269|PubMed:15637062
uniprot
proteins
post_translational_modification
PTM: Degraded by caspases during apoptosis.
uniprot
proteins
protein_family
ABP1 family
uniprot
proteins
pubmed
10567356
uniprot
proteins
pubmed
11689006
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14729663
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15637062
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19768801
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9891087
uniprot
proteins
sequence_length
430
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q62418}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q62418}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q62418}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q62418}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JHL4}. Synapse {ECO:0000250|UniProtKB:Q62418}. Perikaryon {ECO:0000250|UniProtKB:Q62418}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q62418}. Cell membrane {ECO:0000269|PubMed:14729663}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62418}; Cytoplasmic side {ECO:0000250|UniProtKB:Q62418}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q62418}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62418}; Cytoplasmic side {ECO:0000250|UniProtKB:Q62418}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q62418}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62418}; Cytoplasmic side {ECO:0000250|UniProtKB:Q62418}. Cell projection, podosome {ECO:0000250|UniProtKB:Q62418}. Early endosome {ECO:0000269|PubMed:14729663}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9JHL4}. Postsynaptic density {ECO:0000250|UniProtKB:Q9JHL4}. Note=Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes. {ECO:0000250|UniProtKB:Q62418, ECO:0000250|UniProtKB:Q9JHL4}.
uniprot
proteins