Ppargc1a
entrez
19017
canonical
uniprot
O70343
canonical
ensembl
ENSMUSG00000029167
resolver
ensp
ENSMUSP00000117040
resolver
genesymbol
Ppargc1a
resolver
genesymbol_syn
Pgc1
resolver
genesymbol_syn
Pgc1a
resolver
genesymbol_syn
Ppargc1
resolver
uniprot
L0AM20
resolver
uniprot
L0AN96
resolver
uniprot
L0APB0
resolver
uniprot
Q3UP72
resolver
uniprot_entry
PRGC1_MOUSE
resolver
uniprot_sec
L0AM20
resolver
uniprot_sec
L0AN96
resolver
uniprot_sec
L0APB0
resolver
uniprot_sec
Q3UP72
resolver
amino_acid_sequence
MAWDMCSQDSVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPANIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGAVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHAANHTHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCASKKKSHTQPQSQHAQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFKASPKLKPSCKTVVPPPTKRARYSECSGTQGSHSTKKGPEQSELYAQLSKSSGLSRGHEERKTKRPSLRLFGDHDYCQSLNSKTDILINISQELQDSRQLDFKDASCDWQGHICSSTDSGQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPCQAVFDDKSDKTSELRDGDFSNEQFSKLPVFINSGLAMDGLFDDSEDESDKLSYPWDGTQPYSLFDVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEAYEHERLKRDEYRKEHEKRESERAKQRERQKQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDTNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR
uniprot
proteins
function
FUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:12754525, PubMed:15744310, PubMed:23217713, PubMed:9529258). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:12754525, PubMed:15744310, PubMed:23217713, PubMed:9529258). Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed:12754525, PubMed:15744310, PubMed:23217713, PubMed:9529258). Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed:12754525, PubMed:15744310, PubMed:23217713, PubMed:9529258). Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed:12754525). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (By similarity). Also involved in the integration of the circadian rhythms and energy metabolism (PubMed:17476214). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (PubMed:17476214). {ECO:0000250|UniProtKB:Q9UBK2, ECO:0000269|PubMed:12754525, ECO:0000269|PubMed:15744310, ECO:0000269|PubMed:17476214, ECO:0000269|PubMed:23217713, ECO:0000269|PubMed:9529258}.
uniprot
proteins
mass_dalton
90588
uniprot
proteins
mutagenesis
MUTAGEN 142..146; /note="LKKLL->AKKAA: Strongly reduces coactivation of RORA activity."; /evidence="ECO:0000269|PubMed:17476214"; MUTAGEN 177; /note="T->A: Abolishes AMPK-mediated phosphorylation; when associated with A-538."; /evidence="ECO:0000269|PubMed:17609368"; MUTAGEN 538; /note="S->A: Abolishes AMPK-mediated phosphorylation; when associated with A-177."; /evidence="ECO:0000269|PubMed:17609368
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter (PubMed:17609368). Phosphorylated by CLK2 (PubMed:20074525). {ECO:0000269|PubMed:17609368, ECO:0000269|PubMed:20074525}.; PTM: Heavily acetylated by KAT2A/GCN5 under conditions of high nutrients, leading to inactivation of PPARGC1A (PubMed:15744310). Deacetylated by SIRT1 in low nutrients/high NAD conditions, leading to its activation (PubMed:15716268, PubMed:15744310). {ECO:0000269|PubMed:15716268, ECO:0000269|PubMed:15744310}.; PTM: Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation. {ECO:0000250|UniProtKB:Q9UBK2}.
uniprot
proteins
pubmed
11108270
uniprot
proteins
pubmed
12754525
uniprot
proteins
pubmed
14744933
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15716268
uniprot
proteins
pubmed
15744310
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16950137
uniprot
proteins
pubmed
17476214
uniprot
proteins
pubmed
17609368
uniprot
proteins
pubmed
17618855
uniprot
proteins
pubmed
18483224
uniprot
proteins
pubmed
20074525
uniprot
proteins
pubmed
22237023
uniprot
proteins
pubmed
22886304
uniprot
proteins
pubmed
23217713
uniprot
proteins
pubmed
9529258
uniprot
proteins
sequence_length
797
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22886304, ECO:0000269|PubMed:23217713}. Nucleus, PML body {ECO:0000269|PubMed:22886304}.
uniprot
proteins