KNTC2
entrez
10403
canonical
uniprot
O14777
canonical
ensembl
ENSG00000080986
resolver
ensp
ENSP00000261597
resolver
ensp
ENSP00000557817
resolver
ensp
ENSP00000599205
resolver
enst
ENST00000261597
resolver
enst
ENST00000887758
resolver
enst
ENST00000929146
resolver
genesymbol
KNTC2
resolver
genesymbol
NDC80
resolver
genesymbol_syn
HEC
resolver
genesymbol_syn
HEC1
resolver
genesymbol_syn
KNTC2
resolver
genesymbol_syn
NDC80
resolver
hgnc
HGNC:16909
resolver
uniprot
A8K031
resolver
uniprot
Q6PJX2
resolver
uniprot_entry
A8K031_HUMAN
resolver
uniprot_entry
NDC80_HUMAN
resolver
uniprot_sec
Q6PJX2
resolver
amino_acid_sequence
MKRSSVSSGGAGRLSMQELRSQDVNKQGLYTPQTKEKPTFGKLSINKPTSERKVSLFGKRTSGHGSRNSQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLCEFLTENGYAHNVSMKSLQAPSVKDFLKIFTFLYGFLCPSYELPDTKFEEEVPRIFKDLGYPFALSKSSMYTVGAPHTWPHIVAALVWLIDCIKIHTAMKESSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE
uniprot
proteins
function
FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912, PubMed:9315664). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:23891108, PubMed:25743205). {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:9315664}.
uniprot
proteins
mass_dalton
73913
uniprot
proteins
mutagenesis
MUTAGEN 53; /note="K->Q: Mimics acetylation, leading to increased kinetochore-microtubule attachment; when associated with Q-59."; /evidence="ECO:0000269|PubMed:30409912"; MUTAGEN 53; /note="K->R: Impaired acetylation, leading to reduced kinetochore-microtubule attachment; when associated with R-59."; /evidence="ECO:0000269|PubMed:30409912"; MUTAGEN 59; /note="K->Q: Mimics acetylation, leading to increased kinetochore-microtubule attachment; when associated with Q-53."; /evidence="ECO:0000269|PubMed:30409912"; MUTAGEN 59; /note="K->R: Impaired acetylation, leading to reduced kinetochore-microtubule attachment; when associated with R-53."; /evidence="ECO:0000269|PubMed:30409912"; MUTAGEN 234; /note="E->K: Abrogates binding to RB1."; /evidence="ECO:0000269|PubMed:10779342
uniprot
proteins
post_translational_modification
PTM: Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. Also phosphorylated by AURKA and AURKB. {ECO:0000269|PubMed:12386167, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:30409912}.; PTM: Acetylated at Lys-53 and Lys-59 by KAT5 during mitosis, promoting robust kinetochore-microtubule attachment (PubMed:30409912). Deacetylated by SIRT1 (PubMed:30409912). {ECO:0000269|PubMed:30409912}.
uniprot
proteins
protein_family
NDC80/HEC1 family
uniprot
proteins
pubmed
10409732
uniprot
proteins
pubmed
10779342
uniprot
proteins
pubmed
12351790
uniprot
proteins
pubmed
12386167
uniprot
proteins
pubmed
14602875
uniprot
proteins
pubmed
14654001
uniprot
proteins
pubmed
14699129
uniprot
proteins
pubmed
14978040
uniprot
proteins
pubmed
15062103
uniprot
proteins
pubmed
15133482
uniprot
proteins
pubmed
15235793
uniprot
proteins
pubmed
15239953
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15502821
uniprot
proteins
pubmed
15548592
uniprot
proteins
pubmed
15713649
uniprot
proteins
pubmed
15824131
uniprot
proteins
pubmed
15961401
uniprot
proteins
pubmed
15964272
uniprot
proteins
pubmed
16732327
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22581055
uniprot
proteins
pubmed
23085020
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23891108
uniprot
proteins
pubmed
25743205
uniprot
proteins
pubmed
27156448
uniprot
proteins
pubmed
30409912
uniprot
proteins
pubmed
9295362
uniprot
proteins
pubmed
9315664
uniprot
proteins
sequence_length
642
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9315664}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14699129}. Note=Localizes to kinetochores from late prophase to anaphase (PubMed:14699129). Localizes specifically to the outer plate of the kinetochore (PubMed:14699129). {ECO:0000269|PubMed:14699129}.
uniprot
proteins