Atxn1
entrez
25049
canonical
uniprot
Q63540
canonical
ensembl
ENSRNOG00000016998
resolver
ensembl
ENSRNOG00055007647
resolver
ensembl
ENSRNOG00060017739
resolver
ensembl
ENSRNOG00065010152
resolver
ensp
ENSRNOP00000023140
resolver
ensp
ENSRNOP00055010206
resolver
ensp
ENSRNOP00060024532
resolver
ensp
ENSRNOP00065012420
resolver
enst
ENSRNOT00000023140
resolver
enst
ENSRNOT00055012805
resolver
enst
ENSRNOT00060030375
resolver
enst
ENSRNOT00065016363
resolver
genesymbol
Atxn1
resolver
genesymbol_syn
Sca1
resolver
uniprot_entry
ATX1_RAT
resolver
amino_acid_sequence
MKSNQERSNECLPPKKREIPATSRPSEEKATALPSDNHCVEGVAWLPSTPGSRGHGGGRHGPAGTSGEHGLQGMGLHKALSAGLDYSPPSAPRSVPTANTLPTVYPPPQSGTPVSPVQYAHLSHTFQFIGSSQYSGPYAGFIPSQLISPPGNPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQAPGHKVEPPPQQHLGRAAGLVNPGSPPPTQQNQYIHISSSPQSSGRATSPPIPVHLHPHQTMIPHTLTLGPSSQVVVQYSDAGGHFVPRESTKKAESSRLQQAMQAKEVLNGEMEKSRRYGASSSVELSLGKTSSKSVPHPYESRHVVVHPSPADYSSRDTSGVRGSVMVLPNSSTPSADLETQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGAQPPVIGYLSSQQQAITYAGGLPQHLVIPGTQPLLIPVGSPDMDTPGAASAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAASPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASALLKHAKTDSLAGSRHRYAEQENGINQGSAQVLSENGELKFPEKIGLPAAPFLTKIEPSKPTATRKRRWSAPETRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
uniprot
proteins
function
FUNCTION: Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved brain development. {ECO:0000250|UniProtKB:P54253, ECO:0000250|UniProtKB:P54254}.
uniprot
proteins
mass_dalton
83501
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by UBE3A, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:P54254}.; PTM: Phosphorylation at Ser-749 increases the pathogenicity of proteins with an expanded polyglutamine tract. {ECO:0000250|UniProtKB:P54253}.; PTM: Sumoylation is dependent on nuclear localization and phosphorylation at Ser-749. It is reduced in the presence of an expanded polyglutamine tract. {ECO:0000250|UniProtKB:P54253}.
uniprot
proteins
protein_family
ATXN1 family
uniprot
proteins
pubmed
8852664
uniprot
proteins
sequence_length
789
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P54253}. Nucleus {ECO:0000250|UniProtKB:P54253}. Note=Colocalizes with USP7 in the nucleus. {ECO:0000250|UniProtKB:P54253}.
uniprot
proteins