NOX3
entrez
50508
canonical
uniprot
Q9HBY0
canonical
ensembl
ENSG00000074771
resolver
ensp
ENSP00000159060
resolver
enst
ENST00000159060
resolver
genesymbol
NOX3
resolver
genesymbol_syn
MOX2
resolver
hgnc
HGNC:7890
resolver
uniprot
Q9HBJ9
resolver
uniprot_entry
NOX3_HUMAN
resolver
uniprot_sec
Q9HBJ9
resolver
activity_regulation
ACTIVITY REGULATION: Activated by the ototoxic drug cisplatin (By similarity). Activated by NOXO1. Cooperatively activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)-dependent manner. Inhibited by diphenyleneiodonium chloride. {ECO:0000250|UniProtKB:Q672J9, ECO:0000269|PubMed:15181005, ECO:0000269|PubMed:15824103}.
uniprot
proteins
amino_acid_sequence
MMGCWILNEGLSTILVLSWLGINFYLFIDTFYWYEEEESFHYTRVILGSTLAWARASALCLNFNCMLILIPVSRNLISFIRGTSICCRGPWRRQLDKNLRFHKLVAYGIAVNATIHIVAHFFNLERYHWSQSEEAQGLLAALSKLGNTPNESYLNPVRTFPTNTTTELLRTIAGVTGLVISLALVLIMTSSTEFIRQASYELFWYTHHVFIVFFLSLAIHGTGRIVRGQTQDSLSLHNITFCRDRYAEWQTVAQCPVPQFSGKEPSAWKWILGPVVLYACERIIRFWRFQQEVVITKVVSHPSGVLELHMKKRGFKMAPGQYILVQCPAISSLEWHPFTLTSAPQEDFFSVHIRAAGDWTAALLEAFGAEGQALQEPWSLPRLAVDGPFGTALTDVFHYPVCVCVAAGIGVTPFAALLKSIWYKCSEAQTPLKLSKVYFYWICRDARAFEWFADLLLSLETRMSEQGKTHFLSYHIFLTGWDENQALHIALHWDENTDVITGLKQKTFYGRPNWNNEFKQIAYNHPSSSIGVFFCGPKALSRTLQKMCHLYSSADPRGVHFYYNKESF
uniprot
proteins
ec_number
1.6.3.-
uniprot
proteins
function
FUNCTION: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor, upon formation of a complex with CYBA/p22phox (PubMed:15181005, PubMed:15824103). Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (By similarity). {ECO:0000250|UniProtKB:Q672J9, ECO:0000269|PubMed:15181005, ECO:0000269|PubMed:15824103}.
uniprot
proteins
mass_dalton
64935
uniprot
proteins
mutagenesis
MUTAGEN 413; /note="P->H: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:15824103
uniprot
proteins
post_translational_modification
PTM: N-glycosylated in a CYBA/p22phox-dependent manner. {ECO:0000250|UniProtKB:Q672J9}.
uniprot
proteins
pubmed
10974555
uniprot
proteins
pubmed
11376945
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15181005
uniprot
proteins
pubmed
15824103
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q672J9}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..34; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 396..416; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins