Tonsl
entrez
366953
canonical
uniprot
D4A615
canonical
ensembl
ENSRNOG00000014703
resolver
ensp
ENSRNOP00000019754
resolver
genesymbol
Tonsl
resolver
genesymbol_syn
Ikbr
resolver
genesymbol_syn
Nfkbil2
resolver
uniprot_entry
TONSL_RAT
resolver
amino_acid_sequence
MTLEQELRQLSKAKARAQRNGQLCEEAVCCHQLGELLASHGRFQEALEEHQQELHLLESVQDTLGCAVAHRKIGERLAEMENYSAALKHQHLYLDLAGSLSNHTELQRAWATIGRTHLDVYDHCQSRDSLLQAQAAFEKSLAIVDEKLEGMLTQRELSEMRTRLYLNLGLTCESLQQTAQCNNYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRGGQHSQAMRCLEGARECARAMKMRFMESECCMLVSQVLQDLGDFLAAKRALKKAYRLGSQKPNQRVAICQSLKYVLAVVRLQQQLQEAEGNDLQGAMAICEQLGDLFSKADDFPKASEAYQKQLHFAELLNRPDLELAVIHESLATTLGDMKDYHKAVHHYEEELRLRKGNALEEAKTWFNIGLAREEAGDAYELLAPCFQKAFGCAQQAQRYQLQRQILQHLYTVQLKLQPQEARDTEIRLQELSMAKDTEEEEEEEEEEEEEASEALETSEMELSESEDDADGLSQQLEEEEELQGCVGRRKINKWNRRNDMGETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTLRTRKGLSPLETLQQWVKLYFRDLDLETRQKAASMERRLQMASSGQASHSSPALQTIPNNHLFDPETSPPSSPCPKPPSYTPRPPEASPAPAKVFLEETVSAVCRPRKNRHRPASSSSSSEDDDDNTNPCRPSQKRLRHSTQQGEAKTPDPSKSRETAISSACRAAYQAAIRGVGSAQSRRLVPSLPRGSNEVPAPKTALIPEEEFLAEEWLEVDTPLTRSSSSSRPSTSISDYERCPARPRTRAKQSRPASLDGWCTRTKAADASLTAEPTENSSMPRTTGPNKENCAAGQPLLLVQPPPIRVRVQIQDNLFLIPVPHSDVHSVAWLAEQAAQRYFQTCGLLPRLTLRKDGALLAPQDPIPDVLQSNDEVMAEVTSWDLPPLKDRYRRACQSLGQGEHQQVLQAMEHQSSSPSFSACSLALCQAQLTPLLRALKLHTALRELRLSGNRLGDPCATELLATLGTMPNLVLLDLSSNHLGPEGLRQLVEGSLGQTAFQNVEELDLSMNPLGDGCAQALASLLRTCPVLRTLRLQACGFSPSFFLSHQAALGSAFKDAEHLKTLSLSYNTLGAPALARVLQSLPTCTLLHLELSSVAASKSNSSLIEPVIKYLTKEGCALAHLTLSANCLSDKAVRELSRCLPSCPSLTSLDLSANPEVSCAGLEELLSALQERPQGLSFFDLSGCSIQGPLNSDLWDKILSQLQELQLCSKDLTTKDRDTLCQRLPAGACTLNQGSKLFFKCL
uniprot
proteins
function
FUNCTION: Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, TONSL acts as a histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones. Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3.1. {ECO:0000250|UniProtKB:Q96HA7}.
uniprot
proteins
mass_dalton
151834
uniprot
proteins
protein_family
Tonsoku family
uniprot
proteins
sequence_length
1367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96HA7}. Chromosome {ECO:0000250|UniProtKB:Q96HA7}. Cytoplasm {ECO:0000250|UniProtKB:Q96HA7}. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks. Recruited to stalled or collapsed replication forks following histone replacement by histone chaperones ASF1A and the CAF-1 complex: TONSL acts as a histone reader that recognizes and binds newly synthesized histones. {ECO:0000250|UniProtKB:Q96HA7}.
uniprot
proteins