GZMM
entrez
3004
canonical
uniprot
P51124
canonical
ensembl
ENSG00000197540
resolver
ensp
ENSP00000264553
resolver
ensp
ENSP00000476255
resolver
enst
ENST00000264553
resolver
enst
ENST00000592501
resolver
genesymbol
GZMM
resolver
genesymbol_syn
MET1
resolver
hgnc
HGNC:4712
resolver
uniprot
U3KQV5
resolver
uniprot_entry
GRAM_HUMAN
resolver
uniprot_entry
U3KQV5_HUMAN
resolver
amino_acid_sequence
MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLAQRMAQLRLVLGLHTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLARVLSFSSRVCTDIFKPPVATAVAPYVSWIRKVTGRSA
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. {ECO:0000269|PubMed:18523284, ECO:0000269|PubMed:20406824, ECO:0000269|PubMed:8245461}.
uniprot
proteins
mass_dalton
27545
uniprot
proteins
protein_family
Granzyme subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18523284
uniprot
proteins
pubmed
19542453
uniprot
proteins
pubmed
20406824
uniprot
proteins
pubmed
7713495
uniprot
proteins
pubmed
8245461
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8245461}. Cytoplasmic granule {ECO:0000269|PubMed:8245461}. Note=Granules of large granular lymphocytes. {ECO:0000269|PubMed:8245461}.
uniprot
proteins