THEMIS2
entrez
9473
canonical
uniprot
Q5TEJ8
canonical
ensembl
ENSG00000130775
resolver
ensp
ENSP00000329862
resolver
ensp
ENSP00000363031
resolver
ensp
ENSP00000363035
resolver
ensp
ENSP00000363037
resolver
ensp
ENSP00000398049
resolver
ensp
ENSP00000623103
resolver
genesymbol
THEMIS2
resolver
genesymbol_syn
C1orf38
resolver
genesymbol_syn
ICB1
resolver
hgnc
HGNC:16839
resolver
uniprot
A2RTZ3
resolver
uniprot
B4DZT9
resolver
uniprot
B4DZY3
resolver
uniprot
O60560
resolver
uniprot
Q5TEJ1
resolver
uniprot
Q5TEJ9
resolver
uniprot
Q5TEK1
resolver
uniprot
Q68DP4
resolver
uniprot
Q9BYB6
resolver
uniprot
Q9NS90
resolver
uniprot_entry
THMS2_HUMAN
resolver
uniprot_sec
A2RTZ3
resolver
uniprot_sec
B4DZT9
resolver
uniprot_sec
B4DZY3
resolver
uniprot_sec
O60560
resolver
uniprot_sec
Q5TEJ1
resolver
uniprot_sec
Q5TEJ9
resolver
uniprot_sec
Q5TEK1
resolver
uniprot_sec
Q68DP4
resolver
uniprot_sec
Q9BYB6
resolver
uniprot_sec
Q9NS90
resolver
amino_acid_sequence
MEPVPLQDFVRALDPASLPRVLRVCSGVYFEGSIYEISGNECCLSTGDLIKVTQVRLQKVVCENPKTSQTMELAPNFQGYFTPLNTPQSYETLEELVSATTQSSKQLPTCFMSTHRIVTEGRVVTEDQLLMLEAVVMHLGIRSARCVLGMEGQQVILHLPLSQKGPFWTWEPSAPRTLLQVLQDPALKDLVLTCPTLPWHSLILRPQYEIQAIMHMRRTIVKIPSTLEVDVEDVTASSRHVHFIKPLLLSEVLAWEGPFPLSMEILEVPEGRPIFLSPWVGSLQKGQRLCVYGLASPPWRVLASSKGRKVPRHFLVSGGYQGKLRRRPREFPTAYDLLGAFQPGRPLRVVATKDCEGEREENPEFTSLAVGDRLEVLGPGQAHGAQGSDVDVLVCQRLSDQAGEDEEEECKEEAESPERVLLPFHFPGSFVEEMSDSRRYSLADLTAQFSLPCEVKVVAKDTSHPTDPLTSFLGLRLEEKITEPFLVVSLDSEPGMCFEIPPRWLDLTVVKAKGQPDLPEGSLPIATVEELTDTFYYRLRKLPACEIQAPPPRPPKNQGLSKQRRHSSEGGVKSSQVLGLQQHARLPKPKAKTLPEFIKDGSSTYSKIPAHRKGHRPAKPQRQDLDDDEHDYEEILEQFQKTI
uniprot
proteins
function
FUNCTION: May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716). Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity). {ECO:0000250|UniProtKB:Q91YX0, ECO:0000269|PubMed:20644716}.
uniprot
proteins
mass_dalton
72049
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-632 is induced by LPS. Phosphorylated by Src kinases (Lck or Fyn) following BCR engagement. {ECO:0000250|UniProtKB:Q91YX0}.
uniprot
proteins
protein_family
Themis family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20644716
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9563507
uniprot
proteins
sequence_length
643
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91YX0}. Cytoplasm {ECO:0000250|UniProtKB:Q91YX0}.
uniprot
proteins