TMPO
entrez
7112
canonical
uniprot
P42166
canonical
ensembl
ENSG00000120802
resolver
ensp
ENSP00000266732
resolver
ensp
ENSP00000340251
resolver
ensp
ENSP00000376773
resolver
ensp
ENSP00000450627
resolver
enst
ENST00000266732
resolver
enst
ENST00000343315
resolver
genesymbol
TMPO
resolver
genesymbol_syn
LAP2
resolver
hgnc
HGNC:11875
resolver
uniprot
A2T926
resolver
uniprot
G5E972
resolver
uniprot
P08918
resolver
uniprot
P08919
resolver
uniprot
P42167
resolver
uniprot
Q14860
resolver
uniprot
Q14861
resolver
uniprot
Q16295
resolver
uniprot
Q59G12
resolver
uniprot_entry
G5E972_HUMAN
resolver
uniprot_entry
LAP2A_HUMAN
resolver
uniprot_entry
LAP2B_HUMAN
resolver
uniprot_entry
Q59G12_HUMAN
resolver
uniprot_sec
A2T926
resolver
uniprot_sec
P08918
resolver
uniprot_sec
P08919
resolver
uniprot_sec
Q14860
resolver
uniprot_sec
Q14861
resolver
uniprot_sec
Q16295
resolver
amino_acid_sequence
MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLPAGTNSKGPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKPRQEDKDDLDVTELTNEDLLDQLVKYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSSTPLPTISSSAENTRQNGSNDSDRYSDNEEDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQAGITETEWTSGSSKGGPLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTGNFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLFVVVAVFLFLVYQAMETNQVNPFSNFLHVDPRKSN
uniprot
proteins
amino_acid_sequence
MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLPAGTNSKGPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKPRQEDKDDLDVTELTNEDLLDQLVKYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSSTPLPTISSSAENTRQNGSNDSDRYSDNEEGKKKEHKKVKSTRDIVPFSELGTTPSGGGFFQGISFPEISTRPPLGSTELQAAKKVHTSKGDLPREPLVATNLPGRGQLQKLASERNLFISCKSSHDRCLEKSSSSSSQPEHSAMLVSTAASPSLIKETTTGYYKDIVENICGREKSGIQPLCPERSHISDQSPLSSKRKALEESESSQLISPPLAQAIRDYVNSLLVQGGVGSLPGTSNSMPPLDVENIQKRIDQSKFQETEFLSPPRKVPRLSEKSVEERDSGSFVAFQNIPGSELMSSFAKTVVSHSLTTLGLEVAKQSQHDKIDASELSFPFHESILKVIEEEWQQVDRQLPSLACKYPVSSREATQILSVPKVDDEILGFISEATPLGGIQAASTESCNQQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQAAQILSSDPSRTHQALGILSKTYDAASYICEAAFDEVKMAAHTMGNATVGRRYLWLKDCKINLASKNKLASTPFKGGTLFGGEVCKVIKKRGNKH
uniprot
proteins
function
FUNCTION: May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
uniprot
proteins
function
FUNCTION: May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.; FUNCTION: Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
uniprot
proteins
mass_dalton
50670
uniprot
proteins
mass_dalton
75492
uniprot
proteins
post_translational_modification
PTM: Mitosis-specific phosphorylation specifically abolishes its binding to lamin B and chromosomes. {ECO:0000250}.; PTM: Citrullinated by PADI4. {ECO:0000250}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in a mitose-specific manner. {ECO:0000269|PubMed:9707448}.
uniprot
proteins
protein_family
LEM family
uniprot
proteins
pubmed
10806084
uniprot
proteins
pubmed
10984438
uniprot
proteins
pubmed
11435115
uniprot
proteins
pubmed
11500367
uniprot
proteins
pubmed
12475961
uniprot
proteins
pubmed
12538639
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16247757
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17487921
uniprot
proteins
pubmed
17693683
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18403046
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27896284
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28813417
uniprot
proteins
pubmed
3473468
uniprot
proteins
pubmed
7517549
uniprot
proteins
pubmed
7703909
uniprot
proteins
pubmed
8016147
uniprot
proteins
pubmed
8530026
uniprot
proteins
pubmed
9490046
uniprot
proteins
pubmed
9707448
uniprot
proteins
sequence_length
454
uniprot
proteins
sequence_length
694
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus inner membrane; Single-pass type II membrane protein. Note=Tightly associated with the nuclear lamina.; SUBCELLULAR LOCATION: [Isoform Zeta]: Cytoplasm {ECO:0000269|PubMed:18403046}.
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Expressed diffusely throughout the nucleus.
uniprot
proteins
transmembrane_region
TRANSMEM 411..434; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins