Rsad2
entrez
65190
canonical
uniprot
O70600
canonical
ensembl
ENSRNOG00000007539
resolver
ensp
ENSRNOP00000010092
resolver
ensp
ENSRNOP00000103974
resolver
enst
ENSRNOT00000157857
resolver
genesymbol
Rsad2
resolver
genesymbol_syn
Best5
resolver
uniprot
A0ABK0LF61
resolver
uniprot_entry
A0ABK0LF61_RAT
resolver
uniprot_entry
RSAD2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: IRAK1 and TRAF6 synergistically activate RSAD2 increasing its activity with CTP as substrate about 10-fold. {ECO:0000250|UniProtKB:Q8WXG1}.
uniprot
proteins
amino_acid_sequence
MLVPTALAARLLSLFQQQLGSLWSGLAMLFCWLRIALGWPDPGKGQPRVRGEPKETQETHEDPGSAQPTTPVSVNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKRGLLLLKQAGMEKINFSGGEPFLQDRGEYLGKLVRFCKEELALPSVSIVSNGSLIRERWFKDYGDYLDILAISCDSFDEQVNVLIGRGQGKKNHVENLQKLRKWCRDYKVAFKINSVINRFNVDEDMNEHIKALSPVRWKVFQCLLIEGENSGEDALREAERFLISNEEFEAFLQRHKDVSCLVPESNQKMKDSYLILDEYMRFLNCTGGRKDPSRSILDVGVEEAIKFSGFDEKMFLKRGGKYVWSKADLKLDW
uniprot
proteins
ec_number
4.2.-.-
uniprot
proteins
function
FUNCTION: Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses. Also promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins. {ECO:0000250|UniProtKB:Q8WXG1}.
uniprot
proteins
mass_dalton
41255
uniprot
proteins
post_translational_modification
PTM: Acetylated by HAT1. HAT1-mediated acetylation of Lys-196 in turn recruits UBE4A that stimulates RSAD2 polyubiquitination leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q8WXG1}.; PTM: 'Lys-6'-linked polyubiquitination at Lys-205 leads to RSAD2 protein degradation. {ECO:0000250|UniProtKB:Q8WXG1}.
uniprot
proteins
protein_family
RSAD2 family
uniprot
proteins
protein_family
Radical SAM superfamily
uniprot
proteins
pubmed
10698968
uniprot
proteins
pubmed
36387278
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8WXG1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8WXG1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8WXG1}. Golgi apparatus {ECO:0000250|UniProtKB:Q8WXG1}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8WXG1}. Lipid droplet {ECO:0000250|UniProtKB:Q8WXG1}. Mitochondrion {ECO:0000250|UniProtKB:Q8WXG1}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8WXG1}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8WXG1}.
uniprot
proteins