ATP6V0E1
entrez
8992
canonical
uniprot
O15342
canonical
ensembl
ENSG00000113732
resolver
ensp
ENSP00000427941
resolver
ensp
ENSP00000429690
resolver
ensp
ENSP00000607404
resolver
enst
ENST00000517669
resolver
enst
ENST00000519374
resolver
enst
ENST00000937345
resolver
genesymbol
ATP6V0E1
resolver
genesymbol_syn
ATP6H
resolver
genesymbol_syn
ATP6V0E
resolver
hgnc
HGNC:863
resolver
uniprot
B2R557
resolver
uniprot
D3DQM1
resolver
uniprot
Q6IBE8
resolver
uniprot_entry
VA0E1_HUMAN
resolver
uniprot_sec
B2R557
resolver
uniprot_sec
D3DQM1
resolver
uniprot_sec
Q6IBE8
resolver
amino_acid_sequence
MAYHGLTVPLIVMSVFWGFVGFLVPWFIPKGPNRGVIITMLVTCSVCCYLFWLIAILAQLNPLFGPQLKNETIWYLKYHWP
uniprot
proteins
function
FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (PubMed:22053050). {ECO:0000250|UniProtKB:Q2KIB5, ECO:0000269|PubMed:22053050, ECO:0000269|PubMed:33065002}.
uniprot
proteins
mass_dalton
9374
uniprot
proteins
protein_family
V-ATPase e1/e2 subunit family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17350184
uniprot
proteins
pubmed
22053050
uniprot
proteins
pubmed
33065002
uniprot
proteins
pubmed
9556572
uniprot
proteins
sequence_length
81
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins