Tmem178a
entrez
68027
canonical
uniprot
Q9CZ16
canonical
ensembl
ENSMUSG00000024245
resolver
ensp
ENSMUSP00000025092
resolver
enst
ENSMUST00000025092
resolver
genesymbol
Tmem178a
resolver
genesymbol_syn
Tmem178
resolver
uniprot
F8VPV2
resolver
uniprot
Q8CEU4
resolver
uniprot_entry
T178A_MOUSE
resolver
uniprot_sec
F8VPV2
resolver
uniprot_sec
Q8CEU4
resolver
amino_acid_sequence
MEPRALVTALSLGLSLCSLGLLVTAIFTDHWYETDPRRHKESCERSRAGADPPDQKNRLMPLSHLPLRDSPPLGRRLLPGGPGRSDPESWRSLLGLGGLDAECGRPLFATYSGLWRKCYFLGIDRDIDTLILKGIAQRCTAIKYHFSQPIRLRNIPFNLTKTIQQDEWHLLHLRRITAGFLGMAVAVLLCGCIVATVSFFWEESLTQHVAGLLFLMTGIFCTISLCTYAASVSYDLNRVPKLIYSLPHDVEHGYSWSIFCAWCSLGFIVAAGGLCIAYPFISRTKIAHLKSGRDSTV
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1 (PubMed:26644563). {ECO:0000269|PubMed:26644563}.
uniprot
proteins
mass_dalton
33082
uniprot
proteins
protein_family
TMEM178 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26644563
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26644563}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 180..200; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 209..229; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins