Pde6d
entrez
18582
canonical
uniprot
O55057
canonical
ensembl
ENSMUSG00000026239
resolver
ensp
ENSMUSP00000027444
resolver
ensp
ENSMUSP00000187184
resolver
enst
ENSMUST00000027444
resolver
genesymbol
Pde6d
resolver
uniprot
Q3TDQ8
resolver
uniprot_entry
PDE6D_MOUSE
resolver
uniprot_entry
Q3TDQ8_MOUSE
resolver
amino_acid_sequence
MSAKDERARDILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSAEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSKVRLFYV
uniprot
proteins
function
FUNCTION: Promotes the release of prenylated target proteins from cellular membranes (PubMed:22179043). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22179043). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Required for RAB28 localization to the cone cell outer segments in the retina (PubMed:30228185). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (PubMed:22179043). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate. {ECO:0000250|UniProtKB:O43924, ECO:0000250|UniProtKB:Q95142, ECO:0000269|PubMed:10518933, ECO:0000269|PubMed:15979089, ECO:0000269|PubMed:22179043, ECO:0000269|PubMed:30228185}.
uniprot
proteins
mass_dalton
17348
uniprot
proteins
protein_family
PDE6D/unc-119 family
uniprot
proteins
pubmed
10518933
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15979089
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22179043
uniprot
proteins
pubmed
30228185
uniprot
proteins
pubmed
9570951
uniprot
proteins
pubmed
9781033
uniprot
proteins
pubmed
9990021
uniprot
proteins
sequence_length
150
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22179043}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O43924}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43924}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:O43924}.
uniprot
proteins