Cenpn
entrez
361416
canonical
uniprot
Q5U2W4
canonical
ensembl
ENSRNOG00000011296
resolver
ensembl
ENSRNOG00055021644
resolver
ensembl
ENSRNOG00060020792
resolver
ensembl
ENSRNOG00065006455
resolver
ensp
ENSRNOP00000071328
resolver
ensp
ENSRNOP00055030136
resolver
ensp
ENSRNOP00060029701
resolver
ensp
ENSRNOP00065007241
resolver
enst
ENSRNOT00055037049
resolver
enst
ENSRNOT00060036118
resolver
enst
ENSRNOT00065009963
resolver
genesymbol
Cenpn
resolver
uniprot_entry
CENPN_RAT
resolver
amino_acid_sequence
MDENVAEFLRRIILKIPLCEMKTILEAWDFLSEDQLQSINLKQRKEFLAQEVILLCEDKCASLDDMALLDLMYTQFHRHQKLWNVFQMSKEPGGNDVDLFDMEQFQSSFKRILQRALKNVTVSFRVYEKNSVWIRVAWGTQYSQPNQYKPTFVVYYPQTPYVFISSCYLKSTVPLLHQALKVASKHHQMAQLDLRSRHLDSLTAIVFNEYDQTFENYNSTASWREGSLGLKTDLDSKIIHENTEEKVRIHRATQEAFGAYPQPQLEFAQYKLETKFKSDVGGGILADRKEPLRCLVKFSSPHLLEALKSLAPAGIADTPLSPLLTCIPSKKMNYFKIRDK
uniprot
proteins
function
FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000250|UniProtKB:Q96H22}.
uniprot
proteins
mass_dalton
39459
uniprot
proteins
protein_family
CENP-N/CHL4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes exclusively in the kinetochore domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis. {ECO:0000250}.
uniprot
proteins