Mogat2
entrez
233549
canonical
uniprot
Q80W94
canonical
ensembl
ENSMUSG00000052396
resolver
ensp
ENSMUSP00000064041
resolver
enst
ENSMUST00000064231
resolver
genesymbol
Mogat2
resolver
genesymbol_syn
Dgat2l5
resolver
genesymbol_syn
Mgat1l
resolver
uniprot_entry
MOGT2_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by oleic acid and sphingosine, while it is stimulated by phosphatidylcholine, phosphatidylserine and phosphatidic acid. {ECO:0000269|PubMed:12730219}.
uniprot
proteins
amino_acid_sequence
MVEFAPLLVPWERRLQTFAVLQWVFSFLALAQLCIVIFVGLLFTRFWLFSVLYATWWYLDWDKPRQGGRPIQFFRRLAIWKYMKDYFPVSLVKTAELDPSRNYIAGFHPHGVLAAGAFLNLCTESTGFTSLFPGIRSYLMMLTVWFRAPFFRDYIMSGGLVSSEKVSADHILSRKGGGNLLAIIVGGAQEALDARPGAYRLLLKNRKGFIRLALMHGAALVPIFSFGENNLFNQVENTPGTWLRWIQNRLQKIMGISLPLFHGRGVFQYSFGLMPFRQPITTIVGKPIEVQMTPQPSREEVDRLHQRYIKELCKLFEEHKLKFNVPEDQHLEFC
uniprot
proteins
ec_number
2.3.1.20
uniprot
proteins
ec_number
2.3.1.22
uniprot
proteins
function
FUNCTION: Involved in glycerolipid synthesis and lipid metabolism (PubMed:12576479, PubMed:12621063, PubMed:12730219, PubMed:14966132). Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes (Probable). Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol (PubMed:12621063, PubMed:12730219). Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0 (PubMed:12730219). Able to use 1-monoalkylglycerol (1-MAkG, 1-O-alkylglycerol) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG, 1-O-alkyl-3-acylglycerol) (PubMed:12730219). Possesses weak but significant activity with diacylglycerol as substrate, producing triacylglycerol (triacyl-sn-glycerol) (PubMed:12730219). {ECO:0000269|PubMed:12576479, ECO:0000269|PubMed:12621063, ECO:0000269|PubMed:12730219, ECO:0000269|PubMed:14966132, ECO:0000305|PubMed:12730219}.
uniprot
proteins
mass_dalton
38591
uniprot
proteins
pathway_participation
PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis.
uniprot
proteins
protein_family
Diacylglycerol acyltransferase family
uniprot
proteins
pubmed
12576479
uniprot
proteins
pubmed
12621063
uniprot
proteins
pubmed
12730219
uniprot
proteins
pubmed
14966132
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14966132}; Multi-pass membrane protein {ECO:0000269|PubMed:14966132}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q3SYC2}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 212..232; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins