DOC-1R
entrez
10263
canonical
uniprot
O75956
canonical
ensembl
ENSG00000167797
resolver
ensp
ENSP00000301488
resolver
enst
ENST00000301488
resolver
genesymbol
CDK2AP2
resolver
genesymbol
DOC-1R
resolver
genesymbol_syn
CDK2AP2
resolver
genesymbol_syn
DOC1R
resolver
hgnc
HGNC:30833
resolver
uniprot
Q6IAV4
resolver
uniprot_entry
CDKA2_HUMAN
resolver
uniprot_entry
Q6IAV4_HUMAN
resolver
amino_acid_sequence
MSYKPIAPAPSSTPGSSTPGPGTPVPTGSVPSPSGSVPGAGAPFRPLFNDFGPPSMGYVQAMKPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETERNART
uniprot
proteins
function
FUNCTION: Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:33283408). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148). Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs (By similarity). Regulates microtubule organization of metaphase II oocytes (By similarity). {ECO:0000250|UniProtKB:Q9CPY4, ECO:0000269|PubMed:23781148, ECO:0000269|PubMed:33283408}.
uniprot
proteins
mass_dalton
13101
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK1 and CDK2. {ECO:0000250|UniProtKB:Q9CPY4}.
uniprot
proteins
protein_family
CDK2AP family
uniprot
proteins
pubmed
10082655
uniprot
proteins
pubmed
14985111
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23781148
uniprot
proteins
pubmed
33283408
uniprot
proteins
sequence_length
126
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10082655}. Nucleus {ECO:0000269|PubMed:10082655, ECO:0000269|PubMed:33283408}. Note=Accumulates in immature oocytes in the nucleus. During the first meiotic division, accumulates in the cytoplasm and localizes in dots in the vicinity of the chromosomes in a region enriched in microtubules. {ECO:0000250|UniProtKB:Q9CPY4}.
uniprot
proteins