Pde4a
entrez
25638
canonical
uniprot
P54748
canonical
ensembl
ENSRNOG00000020828
resolver
ensp
ENSRNOP00000057815
resolver
ensp
ENSRNOP00000082374
resolver
ensp
ENSRNOP00000082776
resolver
ensp
ENSRNOP00000085157
resolver
ensp
ENSRNOP00000089924
resolver
enst
ENSRNOT00000061100
resolver
enst
ENSRNOT00000096283
resolver
enst
ENSRNOT00000109272
resolver
enst
ENSRNOT00000112455
resolver
genesymbol
Pde4a
resolver
uniprot
A0A8I5ZUU0
resolver
uniprot
A0A8I5ZV79
resolver
uniprot
A0A8I5ZZJ4
resolver
uniprot
F1M8I9
resolver
uniprot
P14645
resolver
uniprot
Q9EQR7
resolver
uniprot_entry
A0A8I5ZUU0_RAT
resolver
uniprot_entry
A0A8I5ZV79_RAT
resolver
uniprot_entry
A0A8I5ZZJ4_RAT
resolver
uniprot_entry
F1M8I9_RAT
resolver
uniprot_entry
PDE4A_RAT
resolver
uniprot_sec
P14645
resolver
uniprot_sec
Q9EQR7
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform 2]: Inhibited by rolipram. {ECO:0000269|PubMed:8557632}.
uniprot
proteins
amino_acid_sequence
MEPPAAPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYPDSAERSETERSPHRPIERADAVDTGDRPGLRTTRMSWPSSFHGTGTGGGSSRRLEAENGPTPSPGRSPLDSQASPGLVLHAGATTSQRRESFLYRSDSDYDMSPKAVSRSSSVASEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPIPSNKRSPLGGPPSVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNEVEIPSPTPRQRAFQQPPPSVLRQSQPMSQITGLKKLVHTGSLNTNVPRFGVKTDQEDLLAQELENLSKWGLNIFCVSEYAGGRSLSCIMYTIFQERDLLKKFHIPVDTMMMYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEENCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNRDWYHSAIRQSPSPPLEEEPGGLGHPSLPDKFQFELTLEEEEEEDSLEVPGLPTTEETFLAAEDARAQAVDWSKVKGPSTTVVEVAERLKQETASAYGAPQESMEAVGCSFSPGTPILPDVRTLSSSEEAPGLLGLPSTAAEVEAPRDHLAATRACSACSGTSGDNSAIISAPGRWGSGGDPA
uniprot
proteins
ec_number
3.1.4.53
uniprot
proteins
function
FUNCTION: Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:21323643, ECO:0000269|PubMed:8557632}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:21323643}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:8557632}.
uniprot
proteins
mass_dalton
93439
uniprot
proteins
mutagenesis
MUTAGEN 147; /note="S->A: Abolishes phosphorylation by MAPKAPK2."; /evidence="ECO:0000269|PubMed:21323643"; MUTAGEN 161; /note="S->A: Does not affect phosphorylation by MAPKAPK2."; /evidence="ECO:0000269|PubMed:21323643
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. {ECO:0000305|PubMed:21323643}.
uniprot
proteins
post_translational_modification
PTM: [Isoform 1]: Phosphorylated by MAPKAPK2 at Ser-147; it counteracts PKA-induced activation of PDE4A and modulates intracellular cAMP levels. Likely involved in cellular desensitization to cAMP signaling. {ECO:0000269|PubMed:21323643}.; PTM: Proteolytically cleaved by CASP3. {ECO:0000250|UniProtKB:P27815}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE4 subfamily
uniprot
proteins
pubmed
11306681
uniprot
proteins
pubmed
21323643
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2542942
uniprot
proteins
pubmed
2546153
uniprot
proteins
pubmed
7958996
uniprot
proteins
pubmed
8557632
uniprot
proteins
pubmed
8663181
uniprot
proteins
sequence_length
844
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:8557632}. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:8557632}.
uniprot
proteins