ATP6V1D
entrez
51382
canonical
uniprot
Q9Y5K8
canonical
ensembl
ENSG00000100554
resolver
ensp
ENSP00000216442
resolver
ensp
ENSP00000451167
resolver
enst
ENST00000216442
resolver
enst
ENST00000554087
resolver
genesymbol
ATP6V1D
resolver
genesymbol_syn
ATP6M
resolver
genesymbol_syn
VATD
resolver
hgnc
HGNC:13527
resolver
uniprot
B2RE33
resolver
uniprot
Q9Y688
resolver
uniprot_entry
VATD_HUMAN
resolver
uniprot_sec
B2RE33
resolver
uniprot_sec
Q9Y688
resolver
amino_acid_sequence
MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSEKDLEQRRAAGEVLEPANLLAEEKDEDLLFE
uniprot
proteins
function
FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (PubMed:22053050). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (PubMed:21844891). {ECO:0000250|UniProtKB:P39942, ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:22053050, ECO:0000269|PubMed:33065002}.
uniprot
proteins
mass_dalton
28263
uniprot
proteins
protein_family
V-ATPase D subunit family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21844891
uniprot
proteins
pubmed
22053050
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
33065002
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:21844891}; Peripheral membrane protein {ECO:0000305|PubMed:21844891}; Cytoplasmic side {ECO:0000305|PubMed:21844891}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P39942}; Peripheral membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000305|PubMed:22053050}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21844891}. Cell projection, cilium {ECO:0000269|PubMed:21844891}. Note=Localizes to centrosome and the base of the cilium. {ECO:0000269|PubMed:21844891}.
uniprot
proteins