Riox1
entrez
314300
canonical
uniprot
D3ZU57
canonical
ensembl
ENSRNOG00000010126
resolver
ensembl
ENSRNOG00055027474
resolver
ensembl
ENSRNOG00060025608
resolver
ensembl
ENSRNOG00065028064
resolver
ensp
ENSRNOP00000013431
resolver
ensp
ENSRNOP00000106685
resolver
ensp
ENSRNOP00000108540
resolver
ensp
ENSRNOP00055039136
resolver
ensp
ENSRNOP00060036730
resolver
ensp
ENSRNOP00065039673
resolver
enst
ENSRNOT00000013431
resolver
enst
ENSRNOT00000148295
resolver
enst
ENSRNOT00000164349
resolver
enst
ENSRNOT00055047559
resolver
enst
ENSRNOT00060044297
resolver
enst
ENSRNOT00065048355
resolver
genesymbol
Riox1
resolver
genesymbol_syn
Mapjd
resolver
genesymbol_syn
No66
resolver
uniprot_entry
RIOX1_RAT
resolver
amino_acid_sequence
MDELPNGNGAAPLKRGRGRRRRQPQPRGASVLALPLRPRKVRRHRKSAASRVAALRARALLSEDSDSNVESVRGKRERPAELPEASRSAEPRPVPVRPRPASATLPRRVEGRAALSRNLGKPAPLPGSHVDDPERPWDSPLQQVLAELNGIPSSRRRAARLFEWLLAPLPPDHFYRRLWEREAVLVRRQDHSYYEGLFSTSDLDWMLRYEDVHFGQHLDAARYIDGRRETLNPPGRALPAAAWSLYQAGCSLRLLCPQAFSPTVWQFLAVLQEQFGSMAGSNVYLTPPNSQGFAPHYDDIEAFVLQLEGRKLWRVYRPRDPSEELALTSSPNFSQEDLGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLSTYQRNTWGDFLEAVLPLAMQAAIEENVEFRRGLPRDFMDYMGAQHSDSKDPRRTAFMEKVRVLVARLGHFAPVDAVADQRAKDFIHDSLPPVLTDRERALSVHGLPIRWEAGEPVNVGAQLTTETQVHMLQDGIARLVGEGGRLFLYYTVENSRVYHLEEPKCLEIYPQQADAMELLLRSYPEFVRVGDLPCDSVEDQLSLATMLYDKGLLLTKTPLVLS
uniprot
proteins
ec_number
1.14.11.27
uniprot
proteins
ec_number
1.14.11.79
uniprot
proteins
function
FUNCTION: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (By similarity). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis. Participates in MYC-induced transcriptional activation (By similarity). {ECO:0000250|UniProtKB:Q9H6W3, ECO:0000250|UniProtKB:Q9JJF3}.
uniprot
proteins
mass_dalton
67455
uniprot
proteins
protein_family
NO66 subfamily
uniprot
proteins
protein_family
ROX family
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
597
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9H6W3}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9H6W3}. Note=Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli. {ECO:0000250|UniProtKB:Q9H6W3}.
uniprot
proteins