Ran
entrez
84509
canonical
uniprot
P62828
canonical
ensembl
ENSRNOG00000000938
resolver
ensembl
ENSRNOG00055000230
resolver
ensembl
ENSRNOG00060011047
resolver
ensembl
ENSRNOG00065001489
resolver
ensp
ENSRNOP00000001247
resolver
ensp
ENSRNOP00055000275
resolver
ensp
ENSRNOP00060014574
resolver
ensp
ENSRNOP00065001404
resolver
enst
ENSRNOT00000001247
resolver
enst
ENSRNOT00055000389
resolver
enst
ENSRNOT00060018702
resolver
enst
ENSRNOT00065001994
resolver
genesymbol
Ran
resolver
uniprot
P17080
resolver
uniprot
P28746
resolver
uniprot
P28747
resolver
uniprot
Q9CSP3
resolver
uniprot
Q9CWI7
resolver
uniprot
Q9CZA2
resolver
uniprot
Q9UDJ5
resolver
uniprot
Q9UEU9
resolver
uniprot_entry
RAN_RAT
resolver
uniprot_sec
P17080
resolver
uniprot_sec
P28746
resolver
uniprot_sec
P28747
resolver
uniprot_sec
Q9CSP3
resolver
uniprot_sec
Q9CWI7
resolver
uniprot_sec
Q9CZA2
resolver
uniprot_sec
Q9UDJ5
resolver
uniprot_sec
Q9UEU9
resolver
amino_acid_sequence
MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. {ECO:0000250|UniProtKB:P62826}.
uniprot
proteins
mass_dalton
24423
uniprot
proteins
post_translational_modification
PTM: Acetylation by KAT5 at Lys-134 is increased during mitosis, impairs RANGRF binding and enhances RCC1 binding. Acetylation at Lys-37 enhances the association with nuclear export components. Deacetylation of Lys-37 by SIRT7 regulates the nuclear export of NF-kappa-B subunit RELA/p65. {ECO:0000250|UniProtKB:P62826}.
uniprot
proteins
protein_family
Ran family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P62826}. Nucleus envelope {ECO:0000250|UniProtKB:P62826}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62826}. Cytoplasm {ECO:0000250|UniProtKB:P62826}. Melanosome {ECO:0000250|UniProtKB:P62826}. Note=Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity). {ECO:0000250|UniProtKB:P62826}.
uniprot
proteins