Ctf1
entrez
29201
canonical
uniprot
Q63086
canonical
ensembl
ENSRNOG00000018962
resolver
ensp
ENSRNOP00000089496
resolver
ensp
ENSRNOP00000099529
resolver
ensp
ENSRNOP00000100511
resolver
ensp
ENSRNOP00000106768
resolver
ensp
ENSRNOP00000108344
resolver
ensp
ENSRNOP00000112131
resolver
genesymbol
Ctf1
resolver
uniprot_entry
CTF1_RAT
resolver
amino_acid_sequence
MSQREGSLEDHQTDSSFSFLPHLEAKIRQTHNLARLLTKYADQLLEEYVQQQGEPFGLPGFSPPRLPLAGLSGPAPSHAGLPVSERLRQDAAALSALPALLDAVRRRQAELNPRAPRLLRSLEDAARQVRALGAAVETVLAALGAAARGPVPEPVATSALFTSNSAAGVFSAKVLGLHVCGLYGEWVSRTEGDLGQLVPGGVA
uniprot
proteins
function
FUNCTION: Functions as a cytokine that binds to the LIF receptor complex (By similarity). The LIF receptor complex indeed consists of two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell (By similarity). Functionally, acts as a potent cardiac survival factor, and promotes cardiomyocyte proliferation and hypertrophy (By similarity). Mechanistically, ligand binding to LIFR, induces heterodimerization with IL6ST/gp130 activating JAK tyrosine kinases (JAK1 or JAK2 and to a lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activator of transcription STAT3 (By similarity). {ECO:0000250|UniProtKB:Q16619, ECO:0000250|UniProtKB:Q60753}.
uniprot
proteins
mass_dalton
21439
uniprot
proteins
protein_family
IL-6 superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8604995
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q16619}.
uniprot
proteins