NENF
entrez
29937
canonical
uniprot
Q9UMX5
canonical
ensembl
ENSG00000117691
resolver
ensp
ENSP00000355955
resolver
enst
ENST00000366988
resolver
genesymbol
NENF
resolver
genesymbol_syn
CIR2
resolver
genesymbol_syn
SPUF
resolver
hgnc
HGNC:30384
resolver
uniprot
A1KYQ8
resolver
uniprot
Q53FZ6
resolver
uniprot
Q5TM90
resolver
uniprot_entry
NENF_HUMAN
resolver
uniprot_sec
A1KYQ8
resolver
uniprot_sec
Q53FZ6
resolver
uniprot_sec
Q5TM90
resolver
amino_acid_sequence
MVGPAPRRRLRPLAALALVLALAPGLPTARAGQTPRPAERGPPVRLFTEEELARYGGEEEDQPIYLAVKGVVFDVTSGKEFYGRGAPYNALTGKDSTRGVAKMSLDPADLTHDTTGLTAKELEALDEVFTKVYKAKYPIVGYTARRILNEDGSPNLDFKPEDQPHFDIKDEF
uniprot
proteins
function
FUNCTION: Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival (PubMed:31536960). Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity is enhanced by binding to heme (By similarity). Also acts as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). {ECO:0000250|UniProtKB:Q9CQ45, ECO:0000269|PubMed:31536960}.
uniprot
proteins
mass_dalton
18856
uniprot
proteins
protein_family
Cytochrome b5 family
uniprot
proteins
protein_family
MAPR subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15605373
uniprot
proteins
pubmed
16645950
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22748190
uniprot
proteins
pubmed
23763432
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28396637
uniprot
proteins
pubmed
31536960
uniprot
proteins
pubmed
9771976
uniprot
proteins
sequence_length
172
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:31536960}. Mitochondrion {ECO:0000269|PubMed:31536960}. Endoplasmic reticulum {ECO:0000269|PubMed:31536960}. Note=Localized to mitochondria and endoplasmic reticulum by PINK1 and PARK7. {ECO:0000269|PubMed:31536960}.
uniprot
proteins