NPL
entrez
80896
canonical
uniprot
Q9BXD5
canonical
ensembl
ENSG00000135838
resolver
ensp
ENSP00000356524
resolver
ensp
ENSP00000356525
resolver
ensp
ENSP00000356526
resolver
ensp
ENSP00000482415
resolver
ensp
ENSP00000652034
resolver
ensp
ENSP00000680810
resolver
enst
ENST00000614468
resolver
genesymbol
NPL
resolver
genesymbol_syn
C1orf13
resolver
hgnc
HGNC:16781
resolver
uniprot
A0A087WZ70
resolver
uniprot
B2R839
resolver
uniprot
Q4G0Q8
resolver
uniprot
Q4G0Z2
resolver
uniprot
Q64L88
resolver
uniprot
Q6PEL0
resolver
uniprot_entry
A0A087WZ70_HUMAN
resolver
uniprot_entry
NPL_HUMAN
resolver
uniprot_sec
B2R839
resolver
uniprot_sec
Q4G0Q8
resolver
uniprot_sec
Q4G0Z2
resolver
uniprot_sec
Q64L88
resolver
uniprot_sec
Q6PEL0
resolver
amino_acid_sequence
MAFPKKKLQGLVAATITPMTENGEINFSVIGQYVDYLVKEQGVKNIFVNGTTGEGLSLSVSERRQVAEEWVTKGKDKLDQVIIHVGALSLKESQELAQHAAEIGADGIAVIAPFFLKPWTKDILINFLKEVAAAAPALPFYYYHIPALTGVKIRAEELLDGILDKIPTFQGLKFSDTDLLDFGQCVDQNRQQQFAFLFGVDEQLLSALVMGATGAVGSTYNYLGKKTNQMLEAFEQKDFSLALNYQFCIQRFINFVVKLGFGVSQTKAIMTLVSGIPMGPPRLPLQKASREFTDSAEAKLKSLDFLSFTDLKDGNLEAGS
uniprot
proteins
ec_number
4.1.3.3
uniprot
proteins
function
FUNCTION: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (PubMed:33895133). It prevents sialic acids from being recycled and returning to the cell surface (PubMed:33895133). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (PubMed:22692205, PubMed:33895133). Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (Probable). {ECO:0000269|PubMed:22692205, ECO:0000269|PubMed:33895133, ECO:0000305|PubMed:22692205}.
uniprot
proteins
mass_dalton
35163
uniprot
proteins
pathway_participation
PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation. {ECO:0000269|PubMed:22692205, ECO:0000269|PubMed:33895133}.
uniprot
proteins
protein_family
DapA family
uniprot
proteins
protein_family
NanA subfamily
uniprot
proteins
pubmed
11318611
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16147865
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
22692205
uniprot
proteins
pubmed
33895133
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins