Cux1
entrez
13047
canonical
uniprot
P53564
canonical
ensembl
ENSMUSG00000029705
resolver
ensp
ENSMUSP00000004097
resolver
ensp
ENSMUSP00000135054
resolver
ensp
ENSMUSP00000135086
resolver
ensp
ENSMUSP00000135223
resolver
ensp
ENSMUSP00000135370
resolver
ensp
ENSMUSP00000135512
resolver
ensp
ENSMUSP00000135892
resolver
ensp
ENSMUSP00000315028
resolver
ensp
ENSMUSP00000315048
resolver
ensp
ENSMUSP00000315049
resolver
ensp
ENSMUSP00000347219
resolver
enst
ENSMUST00000004097
resolver
enst
ENSMUST00000175975
resolver
enst
ENSMUST00000176216
resolver
enst
ENSMUST00000176745
resolver
enst
ENSMUST00000176778
resolver
genesymbol
Cux1
resolver
genesymbol_syn
Cutl1
resolver
genesymbol_syn
Cux
resolver
genesymbol_syn
Kiaa4047
resolver
uniprot
E9QKE9
resolver
uniprot
H3BJN3
resolver
uniprot
H3BK24
resolver
uniprot
H3BKT0
resolver
uniprot
H3BLS0
resolver
uniprot
O08994
resolver
uniprot
P70301
resolver
uniprot
Q571L6
resolver
uniprot
Q5BL05
resolver
uniprot
Q6AXG1
resolver
uniprot
Q91ZD2
resolver
uniprot
Q9JJB6
resolver
uniprot_entry
CUX1_MOUSE
resolver
uniprot_entry
E9QKE9_MOUSE
resolver
uniprot_entry
H3BJN3_MOUSE
resolver
uniprot_entry
H3BK24_MOUSE
resolver
uniprot_entry
H3BKT0_MOUSE
resolver
uniprot_entry
H3BLS0_MOUSE
resolver
uniprot_entry
Q5BL05_MOUSE
resolver
uniprot_entry
Q6AXG1_MOUSE
resolver
uniprot_entry
Q9JJB6_MOUSE
resolver
uniprot_sec
O08994
resolver
uniprot_sec
P70301
resolver
uniprot_sec
Q571L6
resolver
uniprot_sec
Q91ZD2
resolver
amino_acid_sequence
MLCVAGAKLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLTVYKRLIDVPDPVPALDVGQQLEIKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKSQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKLQTLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLNAKNSTLKQLEEKLKGQADYEEVKKELNTLKSMEFAPSEGAGTQDSTKPLEVLLLEKNRSLQSENATLRISNSDLSGSARRKGRDQPESRRPGPLPASPPPQLPRNTGEQVSNTNGTHHFSPAGLSQDFFSSNLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSTIFSTGPYSTNSISSPSPLQQSPDVNGMAPSPSQSESAGSISEGEEIDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNRSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPVQTSSTSSSGNSDDAIRSILQQARREMEAQQAALDPALKPAPLSQPDLTILTPKHLSASPMSTVSTYPPLAISLKKTPAAPETSTAALPSAPALKKEAQDVPTLDPPGSADAAQGVLRPMKSELVRGSTWKDPWWSPIQPERRNLTSSEETKADETTASGKERAGSSQPRAERSQLQGPSASAEYWKEWPSAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMAKPAKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVASLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPAIETSKEGKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGIDYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEELATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSSRAAPSSEGDSCDGVEATDAEEPGGNIVATKSQGGLAEVAAAPADREEATQPAEKAKAQPLCSGTPGQDDGEDASRPRPLPEGLADAPAPVPSLAAPAAGEDAATSATAPATATEAPGAARAGPAERSSALPSTSAPANAPARRPSSLQSLFGLPEAAGARDNPVRKKKAANLNSIIHRLEKAASREEPIEWEF
uniprot
proteins
function
FUNCTION: Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III (PubMed:20510857). Also involved in the control of synaptogenesis (Probable). In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000269|PubMed:11544187, ECO:0000269|PubMed:15371550, ECO:0000269|PubMed:20510857, ECO:0000269|PubMed:9858552, ECO:0000305|PubMed:20510857}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.
uniprot
proteins
mass_dalton
165596
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA. {ECO:0000250|UniProtKB:P53565}.; PTM: As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa by CTSL. Cell cycle-dependent processing of CUX1 serves to generate a CDP/Cux p110 with distinct DNA binding and transcriptional properties. {ECO:0000269|PubMed:15099520}.
uniprot
proteins
protein_family
CUT homeobox family
uniprot
proteins
pubmed
10373541
uniprot
proteins
pubmed
11544187
uniprot
proteins
pubmed
15099520
uniprot
proteins
pubmed
15371550
uniprot
proteins
pubmed
20510857
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7910552
uniprot
proteins
pubmed
8840273
uniprot
proteins
pubmed
8879483
uniprot
proteins
pubmed
9858552
uniprot
proteins
sequence_length
1515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00374, ECO:0000269|PubMed:15371550}.
uniprot
proteins