Tent5c
entrez
74645
canonical
uniprot
Q5SSF7
canonical
ensembl
ENSMUSG00000044468
resolver
ensp
ENSMUSP00000056872
resolver
ensp
ENSMUSP00000363368
resolver
enst
ENSMUST00000061455
resolver
genesymbol
Tent5c
resolver
genesymbol_syn
Fam46c
resolver
uniprot
Q0P629
resolver
uniprot
Q80XL2
resolver
uniprot
Q9CUN7
resolver
uniprot_entry
TET5C_MOUSE
resolver
uniprot_sec
Q0P629
resolver
uniprot_sec
Q80XL2
resolver
uniprot_sec
Q9CUN7
resolver
amino_acid_sequence
MAEEGSSTKDSESFSVLNWDQVSRLHEVLTEVVPIHGRGNFPTLEITLKDIVQTVRGRLEEAGINVQDVRLNGSAAGHVLVKDNGLGCKDLDLIFHVALPTEAEFQLVRDVVLCSLLNFLPEGVNKLKISPVTLKEAYVQKLVKVCTDTDRWSLISLSNKNGRNVELKFVDSIRRQFEFSVDSFQIILDSLLFFYDCSGNPISEHFHPTVIGESMYGDFEEAFDHLQNRLIATKNPEEIRGGGLLKYSNLLVRDFRPADQEEIKTLERYMCSRFFIDFPDILEQQRKLETYLQNHFSDEERSKYDYLMILRRVVNESTVCLMGHERRQTLNLISLLALRVLAEQNIIPSATNVTCYYQPAPYVSDGNFNNYYIAHPPITYSQPYPTWLPCN
uniprot
proteins
ec_number
2.7.7.19
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression (PubMed:34048638). Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich (By similarity). Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein (PubMed:28931820). {ECO:0000250|UniProtKB:Q5VWP2, ECO:0000269|PubMed:28931820, ECO:0000269|PubMed:34048638}.
uniprot
proteins
mass_dalton
44797
uniprot
proteins
mutagenesis
MUTAGEN 72; /note="N->A: Does not affect polynucleotide adenylyltransferase activity. Increases cell apoptosis."; /evidence="ECO:0000269|PubMed:34048638"; MUTAGEN 72; /note="N->H: Significantly increases polynucleotide adenylyltransferase activity."; /evidence="ECO:0000269|PubMed:34048638"; MUTAGEN 73; /note="G->A: Loss of polynucleotide adenylyltransferase activity."; /evidence="ECO:0000269|PubMed:34048638"; MUTAGEN 74; /note="S->A: Loss of polynucleotide adenylyltransferase activity."; /evidence="ECO:0000269|PubMed:34048638"; MUTAGEN 77; /note="G->S: Increases polynucleotide adenylyltransferase activity."; /evidence="ECO:0000269|PubMed:34048638"; MUTAGEN 90; /note="D->A: Loss of polynucleotide adenylyltransferase activity."; /evidence="ECO:0000269|PubMed:34048638"; MUTAGEN 92; /note="D->A: Loss of polynucleotide adenylyltransferase activity."; /evidence="ECO:0000269|PubMed:34048638"; MUTAGEN 146; /note="C->A: Significantly reduces polynucleotide adenylyltransferase activity."; /evidence="ECO:0000269|PubMed:34048638"; MUTAGEN 166; /note="E->A: Loss of polynucleotide adenylyltransferase activity."; /evidence="ECO:0000269|PubMed:34048638"; MUTAGEN 175; /note="R->A: Loss of polynucleotide adenylyltransferase activity."; /evidence="ECO:0000269|PubMed:34048638"; MUTAGEN 240; /note="R->A: Loss of polynucleotide adenylyltransferase activity."; /evidence="ECO:0000269|PubMed:34048638"; MUTAGEN 248; /note="S->A: Does not affect polynucleotide adenylyltransferase activity. Increases cell apoptosis."; /evidence="ECO:0000269|PubMed:34048638"; MUTAGEN 268; /note="R->A: Significantly reduces polynucleotide adenylyltransferase activity."; /evidence="ECO:0000269|PubMed:34048638"; MUTAGEN 290; /note="T->R: Increases polynucleotide adenylyltransferase activity."; /evidence="ECO:0000269|PubMed:34048638"; MUTAGEN 295; /note="H->A: Loss of polynucleotide adenylyltransferase activity."; /evidence="ECO:0000269|PubMed:34048638"; MUTAGEN 298; /note="D->G: Increases polynucleotide adenylyltransferase activity."; /evidence="ECO:0000269|PubMed:34048638
uniprot
proteins
protein_family
TENT family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28931820
uniprot
proteins
pubmed
34048638
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5VWP2}. Cytoplasm {ECO:0000269|PubMed:28931820}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5VWP2}. Note=Recruited into the centrosome through its interaction with PLK4. {ECO:0000250|UniProtKB:Q5VWP2}.
uniprot
proteins