Sfrp4
entrez
89803
canonical
uniprot
Q9JLS4
canonical
ensembl
ENSRNOG00000054957
resolver
ensp
ENSRNOP00000075046
resolver
genesymbol
Sfrp4
resolver
genesymbol_syn
Ddc4
resolver
genesymbol_syn
Frp
resolver
uniprot
O35222
resolver
uniprot
Q9JLS5
resolver
uniprot_entry
SFRP4_RAT
resolver
uniprot_sec
O35222
resolver
uniprot_sec
Q9JLS5
resolver
amino_acid_sequence
MLLSILVALCLCVRLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSSVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLPEDVKWIDITPDMMVQERSFDADCKHLSPDRCKCKKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVVDVKEIFKSSSPIPRTQVPLITNSSCQCPHILPHQDVLIMCYERRSRMMLLENCLVEKWRDQLSRRSTQWEERLQEQQRTTQDKKQIASRTSRSNPPKPKGRSPASKPASPKKNIKARSAPKKSNPKKSTS
uniprot
proteins
function
FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis (By similarity). May also act as a regulator of adult uterine morphology and function (PubMed:12063187). May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (PubMed:12960062). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity). {ECO:0000250|UniProtKB:Q6FHJ7, ECO:0000250|UniProtKB:Q9Z1N6, ECO:0000303|PubMed:12063187, ECO:0000303|PubMed:12960062}.
uniprot
proteins
mass_dalton
39762
uniprot
proteins
protein_family
Secreted frizzled-related protein (sFRP) family
uniprot
proteins
pubmed
11485313
uniprot
proteins
pubmed
12063187
uniprot
proteins
pubmed
12960062
uniprot
proteins
pubmed
9409757
uniprot
proteins
pubmed
9510961
uniprot
proteins
sequence_length
348
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6FHJ7}.
uniprot
proteins