FAM220A
entrez
84792
canonical
uniprot
Q7Z4H9
canonical
ensembl
ENSG00000178397
resolver
ensp
ENSP00000317289
resolver
ensp
ENSP00000432444
resolver
ensp
ENSP00000436886
resolver
enst
ENST00000313324
resolver
enst
ENST00000524898
resolver
enst
ENST00000530143
resolver
genesymbol
FAM220A
resolver
genesymbol_syn
C7orf70
resolver
genesymbol_syn
SIPAR
resolver
hgnc
HGNC:22422
resolver
uniprot
Q75ML2
resolver
uniprot
Q8NA52
resolver
uniprot
Q9BRR7
resolver
uniprot_entry
F220A_HUMAN
resolver
uniprot_sec
Q75ML2
resolver
uniprot_sec
Q8NA52
resolver
uniprot_sec
Q9BRR7
resolver
amino_acid_sequence
MRDRRGPLGTCLAQVQQAGGGDSDKLSCSLKKRMPEGPWPADAPSWMNKPVVDGNSQSEALSLEMRKDPSGAGLWLHSGGPVLPYVRESVRRNPASAATPSTAVGLFPAPTECFARVSCSGVEALGRRDWLGGGPRATDGHRGQCPKGEPRVSRLPRHQKVPEMGSFQDDPPSAFPKGLGSELEPACLHSILSATLHVYPEVLLSEETKRIFLDRLKPMFSKQTIEFKKMLKSTSDGLQITLGLLALQPFELANTLCHS
uniprot
proteins
function
FUNCTION: Promotes dephosphorylation of transcriptional activator STAT3 by interacting with both STAT3 and protein phosphatase PTPN2. This promotes interaction of PTPN2 with STAT3 and mediates STAT3 dephosphorylation by PTPN2, leading to negative regulation of STAT3 transcriptional activator activity. May be required for spermiogenesis or sperm function. {ECO:0000250|UniProtKB:Q3ZN08}.
uniprot
proteins
mass_dalton
28021
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3ZN08}. Cytoplasm {ECO:0000250|UniProtKB:Q3ZN08}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q3ZN08}. Note=Localizes to both nucleus and cytoplasm but located predominantly in the nucleus. Detected in the sperm acrosome prior to the acrosome reaction and is likely to be released from acrosome-reacted sperm. {ECO:0000250|UniProtKB:Q3ZN08}.
uniprot
proteins