HLA-DMB
entrez
3109
canonical
uniprot
P28068
canonical
ensembl
ENSG00000226264
resolver
ensembl
ENSG00000234154
resolver
ensembl
ENSG00000239329
resolver
ensembl
ENSG00000241296
resolver
ensembl
ENSG00000241674
resolver
ensembl
ENSG00000242092
resolver
ensembl
ENSG00000242386
resolver
ensembl
ENSG00000242574
resolver
ensp
ENSP00000372718
resolver
ensp
ENSP00000378723
resolver
ensp
ENSP00000393646
resolver
ensp
ENSP00000398890
resolver
ensp
ENSP00000408453
resolver
ensp
ENSP00000411321
resolver
ensp
ENSP00000413471
resolver
ensp
ENSP00000414817
resolver
enst
ENST00000383231
resolver
enst
ENST00000395312
resolver
enst
ENST00000412948
resolver
enst
ENST00000418107
resolver
enst
ENST00000424822
resolver
enst
ENST00000428420
resolver
enst
ENST00000440078
resolver
enst
ENST00000450897
resolver
genesymbol
HLA-DMB
resolver
genesymbol_syn
DMB
resolver
genesymbol_syn
RING7
resolver
hgnc
HGNC:4935
resolver
uniprot
O77936
resolver
uniprot
Q13012
resolver
uniprot
Q29751
resolver
uniprot
Q58ZE2
resolver
uniprot
Q5SNZ8
resolver
uniprot
Q5STC4
resolver
uniprot
Q9XRX2
resolver
uniprot_entry
DMB_HUMAN
resolver
uniprot_sec
O77936
resolver
uniprot_sec
Q13012
resolver
uniprot_sec
Q29751
resolver
uniprot_sec
Q58ZE2
resolver
uniprot_sec
Q5SNZ8
resolver
uniprot_sec
Q5STC4
resolver
uniprot_sec
Q9XRX2
resolver
amino_acid_sequence
MITFLPLLLGLSLGCTGAGGFVAHVESTCLLDDAGTPKDFTYCISFNKDLLTCWDPEENKMAPCEFGVLNSLANVLSQHLNQKDTLMQRLRNGLQNCATHTQPFWGSLTNRTRPPSVQVAKTTPFNTREPVMLACYVWGFYPAEVTITWRKNGKLVMPHSSAHKTAQPNGDWTYQTLSHLALTPSYGDTYTCVVEHTGAPEPILRDWTPGLSPMQTLKVSVSAVTLGLGLIIFSLGVISWRRAGHSSYTPLPGSNYSEGWHIS
uniprot
proteins
function
FUNCTION: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}.
uniprot
proteins
mass_dalton
28931
uniprot
proteins
mutagenesis
MUTAGEN 26; /note="E->K: Decreases the interaction with MHCII and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 49; /note="D->K: Decreases the interaction with MHCII and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 49; /note="D->N: Increases the interaction with MHCII and peptide exchange; when associated with Q-65."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 65; /note="E->Q: Increases the interaction with MHCII and peptide exchange; when associated with N-49."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 65; /note="E->R: Decreases the interaction with MHCII and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 69; /note="L->D: Decreases the interaction with MHCII and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 73; /note="A->V: Decreases the interaction with MHCII and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 128; /note="R->S: Decreases the interaction with MHCII and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 248; /note="Y->A: Abolishes targeting to endosomes and results in relocalization to the cell membrane."; /evidence="ECO:0000269|PubMed:8757605"; MUTAGEN 251; /note="L->A: Abolishes targeting to endosomes and results in relocalization to the cell membrane."; /evidence="ECO:0000269|PubMed:8757605
uniprot
proteins
protein_family
MHC class II family
uniprot
proteins
pubmed
10885572
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15787724
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16547258
uniprot
proteins
pubmed
1922365
uniprot
proteins
pubmed
23260142
uniprot
proteins
pubmed
8034636
uniprot
proteins
pubmed
8225438
uniprot
proteins
pubmed
8406617
uniprot
proteins
pubmed
8568858
uniprot
proteins
pubmed
8757605
uniprot
proteins
pubmed
8849454
uniprot
proteins
pubmed
9157091
uniprot
proteins
pubmed
9768757
uniprot
proteins
sequence_length
263
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Lysosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
uniprot
proteins
transmembrane_region
TRANSMEM 219..239; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins