Ppp3cc
entrez
19057
canonical
uniprot
P48455
canonical
ensembl
ENSMUSG00000022092
resolver
ensp
ENSMUSP00000077532
resolver
ensp
ENSMUSP00000153725
resolver
ensp
ENSMUSP00000272252
resolver
ensp
ENSMUSP00000272253
resolver
ensp
ENSMUSP00000272265
resolver
ensp
ENSMUSP00000272267
resolver
ensp
ENSMUSP00000272275
resolver
enst
ENSMUST00000078434
resolver
enst
ENSMUST00000228911
resolver
genesymbol
Ppp3cc
resolver
genesymbol_syn
Calnc
resolver
uniprot
A0A2I3BPC5
resolver
uniprot
Q3V074
resolver
uniprot
Q80XK0
resolver
uniprot_entry
A0A2I3BPC5_MOUSE
resolver
uniprot_entry
PP2BC_MOUSE
resolver
uniprot_entry
Q80XK0_MOUSE
resolver
uniprot_sec
Q3V074
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)-bound calmodulin following an increase in intracellular Ca(2+). At low Ca(2+) concentrations, the catalytic subunit (also known as calcineurin A) is inactive and is bound to the regulatory subunit (also known as calcineurin B) in which only two high-affinity binding sites are occupied by Ca(2+). In response to elevated calcium levels, the occupancy of the low-affinity sites on calcineurin B by Ca(2+) causes a conformational change of the C-terminal regulatory domain of calcineurin A, resulting in the exposure of the calmodulin-binding domain and in the partial activation of calcineurin A. The subsequent binding of Ca(2+)-bound calmodulin leads to the displacement of the autoinhibitory domain from the active site and possibly of the autoinhibitory segment from the substrate binding site which fully activates calcineurin A. {ECO:0000250|UniProtKB:P16298}.
uniprot
proteins
amino_acid_sequence
MSVRRPQFSTTERVIKAVPFPPTRRLTLKEVFENGKPKMDLLKNHLVKEGRVEEEVALKIINDGAAILKQEKTMIEVEAPITVCGDVHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTEYFTFKQECRIKYSEMVYDACMHTFDCLPLAALLNQQFLCVHGGMSPEITCLEDIRKLDRFSEPPAFGPVCDLLWSDPLEDYGSEKTLEHYTHNTVRGCSYFFSYPAVCEFLQNNSLLSIIRAHEAQDAGYRMYRKNQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDEEMNVTDEEGATTGRKEVIKNKIRAIGKMARVFTVLREESENVLTLKGLTPTGTLPLGVLSGGKQTIETAKQEAAEEREAIRGFTIAHRIRSFEEARGLDRINERMPPRKEASYHHDAGRMHSHSHPPHPQASRRTDHGKKAL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. {ECO:0000250|UniProtKB:P48454}.
uniprot
proteins
mass_dalton
58699
uniprot
proteins
protein_family
PP-2B subfamily
uniprot
proteins
protein_family
PPP phosphatase family
uniprot
proteins
pubmed
1309945
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16286645
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31696965
uniprot
proteins
pubmed
34446558
uniprot
proteins
sequence_length
513
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:34446558}. Note=Localizes in the mitochondria in a SPATA33-dependent manner. {ECO:0000269|PubMed:34446558}.
uniprot
proteins