MAP3K3
entrez
4215
canonical
uniprot
Q99759
canonical
ensembl
ENSG00000198909
resolver
ensp
ENSP00000354485
resolver
ensp
ENSP00000354927
resolver
ensp
ENSP00000462086
resolver
ensp
ENSP00000464130
resolver
ensp
ENSP00000797864
resolver
ensp
ENSP00000797865
resolver
ensp
ENSP00000797866
resolver
ensp
ENSP00000797867
resolver
enst
ENST00000577395
resolver
enst
ENST00000584573
resolver
genesymbol
MAP3K3
resolver
genesymbol_syn
MAPKKK3
resolver
genesymbol_syn
MEKK3
resolver
hgnc
HGNC:6855
resolver
uniprot
B2RCW2
resolver
uniprot
D3DU15
resolver
uniprot
J3KRN4
resolver
uniprot
J3QRB6
resolver
uniprot
Q5BKZ6
resolver
uniprot
Q8N3I9
resolver
uniprot
Q96HN9
resolver
uniprot_entry
J3KRN4_HUMAN
resolver
uniprot_entry
J3QRB6_HUMAN
resolver
uniprot_entry
M3K3_HUMAN
resolver
uniprot_entry
Q96HN9_HUMAN
resolver
uniprot_sec
B2RCW2
resolver
uniprot_sec
D3DU15
resolver
uniprot_sec
Q5BKZ6
resolver
uniprot_sec
Q8N3I9
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-530. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLMY
uniprot
proteins
disease_involvement
DISEASE: Cerebral cavernous malformations 5 (CCM5) [MIM:621032]: A form of cerebral cavernous malformations, a congenital vascular anomaly of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters. {ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}.
uniprot
proteins
mass_dalton
70898
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-166 and Ser-337 by SGK1 inhibits its activity. {ECO:0000269|PubMed:12761204}.
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
12761204
uniprot
proteins
pubmed
12912994
uniprot
proteins
pubmed
14661019
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14743216
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
33729480
uniprot
proteins
pubmed
33891857
uniprot
proteins
pubmed
9006902
uniprot
proteins
sequence_length
626
uniprot
proteins