PDE8B
entrez
8622
canonical
uniprot
O95263
canonical
ensembl
ENSG00000113231
resolver
ensembl
ENSG00000284762
resolver
ensp
ENSP00000264917
resolver
ensp
ENSP00000330428
resolver
ensp
ENSP00000331336
resolver
ensp
ENSP00000345446
resolver
ensp
ENSP00000345646
resolver
ensp
ENSP00000493971
resolver
ensp
ENSP00000695415
resolver
ensp
ENSP00000695416
resolver
ensp
ENSP00000695417
resolver
ensp
ENSP00000794920
resolver
enst
ENST00000646262
resolver
genesymbol
PDE8B
resolver
hgnc
HGNC:8794
resolver
uniprot
A0A2R8Y4E6
resolver
uniprot
B3KN77
resolver
uniprot
Q5J7V7
resolver
uniprot
Q86XK8
resolver
uniprot
Q8IUJ7
resolver
uniprot
Q8IUJ8
resolver
uniprot
Q8IUJ9
resolver
uniprot
Q8IUK0
resolver
uniprot
Q8N3T2
resolver
uniprot_entry
A0A2R8Y4E6_HUMAN
resolver
uniprot_entry
B3KN77_HUMAN
resolver
uniprot_entry
PDE8B_HUMAN
resolver
uniprot_sec
Q5J7V7
resolver
uniprot_sec
Q86XK8
resolver
uniprot_sec
Q8IUJ7
resolver
uniprot_sec
Q8IUJ8
resolver
uniprot_sec
Q8IUJ9
resolver
uniprot_sec
Q8IUK0
resolver
uniprot_sec
Q8N3T2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by dipyridimole. Insensitive to selective PDE inhibitors including rolipram and milrinone as well as to the non-selective inhibitor, IBMX. Unaffected by cGMP. {ECO:0000269|PubMed:12681444}.
uniprot
proteins
amino_acid_sequence
MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASGPPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
uniprot
proteins
disease_involvement
DISEASE: Striatal degeneration, autosomal dominant 1 (ADSD1) [MIM:609161]: A movement disorder affecting the striatal part of the basal ganglia and characterized by bradykinesia, dysarthria and muscle rigidity. These symptoms resemble idiopathic Parkinson disease, but tremor is not present. {ECO:0000269|PubMed:20085714}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Primary pigmented nodular adrenocortical disease 3 (PPNAD3) [MIM:614190]: A rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Adrenal glands show overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. {ECO:0000269|PubMed:18431404}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.4.53
uniprot
proteins
function
FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.
uniprot
proteins
mass_dalton
98979
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE8 subfamily
uniprot
proteins
pubmed
12372422
uniprot
proteins
pubmed
12681444
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18431404
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20085714
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9784418
uniprot
proteins
sequence_length
885
uniprot
proteins