Pask
entrez
269224
canonical
uniprot
Q8CEE6
canonical
ensembl
ENSMUSG00000026274
resolver
ensp
ENSMUSP00000027493
resolver
ensp
ENSMUSP00000332834
resolver
ensp
ENSMUSP00000332835
resolver
ensp
ENSMUSP00000332839
resolver
enst
ENSMUST00000027493
resolver
genesymbol
Pask
resolver
genesymbol_syn
Kiaa0135
resolver
uniprot
E9QM58
resolver
uniprot
Q91YD8
resolver
uniprot_entry
PASK_MOUSE
resolver
uniprot_sec
E9QM58
resolver
uniprot_sec
Q91YD8
resolver
activity_regulation
ACTIVITY REGULATION: Protein kinase activity is inhibited by the first PAS domain: binding of an unidentified ligand desinhibits the protein kinase activity. May be activated by autophosphorylation on Thr-1221 and Thr-1225. Autophosphorylation is enhanced upon phosphatidylinositol monophosphate (phosphatidylinositol 4-phosphate) binding and inhibited upon phosphatidylinositol bi- and tri-phosphate binding. In contrast, phosphorylation of target proteins is inhibited upon all phosphatidylinositol-binding (phosphatidylinositol mono- bi- and tri-phosphate) (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MEDRGPPVFAEDWKCLSESPPVQEGPAAQATFEPSKPLSIAHKHLSRKNGLSRLCQSRMALSEDRWSSYCLSSLAAQNICTSKLHCAAAPEYADPTAGPLGSTSCCSLLRGLASGCSGSLLSTPVCNPNKAVFTVDAKTTEILVANDKACSLLGYSSHDLIGQKLAQFFLKSDSEVVEALSEEHVEADGHAAVVFGTVVDIVSRIGEKIPVSVWIKRLQQDRGLCCVVVLEPVERVSAWVAFQSDGTITSCDSLFAHLHGFTSPKDVVGQCVIDLIPSMQLPPPGQHIPKSLKIQRSVGRARDGTTFPLSLKLKSKPSGRAVADSEAASEPGYQASVWVFCTISGLITLLPDGTIYGVNHSFALMLFGYGKTELLGKNITFLIPGFYHYMDLTYDSSVQLPDLVNCLDIGRKSGPGEMNSDAQHNWELASGAQGPRIDVVLARDHMPSQDETLKLVGGQVSSRTQTRLETGYKILPSSACQPSLGVDSNPEDGEQSLLTDQQSIPKRNLPAHGGQNQLDTSEISLPVLKEHLLSEIQKNISEESPLTHRKWLSKVQQNPTKGSLPIHEEQLLFAGQHIHVLGKEDPSAAESYRESLLEESKSKPVDAKLFASCEDSEPLVSVKDRGSSVDTCNLHQEAQLELMGVSSPNPWADATMPEPHTTGQIAGGSLTYCPQYRSEWASQQRGQDSAPSPSGMACVLLGTPTLDEPWPGVRNDREELQTCLIKEQLSKSSCEGNLGISRVELVPEEHPPFTAPVSFCDLGGRDLHASRSGSSSACYALATDLPGVLEAVEAQEADVNSYSWNLKELFLKDQTDRTPSHCSCTTSELSEAPSLSVVGSDLDVGILHRQTSDILVDREMLLLTGTYFDLSEGQRFQEMGAGHDRAELSNISLVSSEHYETSDIESPGCDPPLPDPGPNDMCLSAEKPRPSAQITSTPVARGATSLQQEIQEGIYSGSCYHRDGLQLSIQFEVKRVELQGSATLFCCWLVKDLFHSHRDSATRTRLFLASLPSSTHSMPELSGSSFGEVLRAKPWFEESPTPAELEGLAACEGEYDYKYNTISPLGSGAFGFVWTAVEKECNKEVVVKFIKKEKVLEDCWIEDPKLGRVTLEIAILSKVDHANIIKVLDIFENQEFFQLVMEKHGSGMDLFAFIDHHPCLDEPLASFIFRQLVSAVGYLHSQGIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLIGNPYRGPELEMWSLGVTLYTLIFEENPFCEVEETMEAVIHPPFLVSQELMSLLSGLLQPCPEQRTTLEKLIRDPWVTQPVNLASYTWEEVCRTNQPESGLLSAASLEIGSRSPSEMAQREGLCGPPAPRETRGDQHCLHLKDPSLPVS
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidence. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:15148392, ECO:0000269|PubMed:17878307, ECO:0000269|PubMed:18509100, ECO:0000269|PubMed:21181396}.
uniprot
proteins
mass_dalton
151250
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on Thr-1221 and Thr-1225. Autophosphorylation is activated by phospholipids (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11688972
uniprot
proteins
pubmed
12972598
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15148392
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17192472
uniprot
proteins
pubmed
17878307
uniprot
proteins
pubmed
18509100
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21181396
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails. {ECO:0000250}.
uniprot
proteins