Filip1
entrez
246776
canonical
uniprot
Q8K4T4
canonical
ensembl
ENSRNOG00000011521
resolver
ensp
ENSRNOP00000015365
resolver
genesymbol
Filip1
resolver
uniprot
Q8JZS5
resolver
uniprot_entry
FLIP1_RAT
resolver
uniprot_sec
Q8JZS5
resolver
amino_acid_sequence
MRSRNQGGESSSNGHVSCPKSSIISSDGGKGPSEDAKKNKANRKEEDVMASGTIKRHLKPSGESEKKTKKSVELSKEDLIQLLSIMEGELQAREDVIHMLRTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAVTYKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLSQRIEELEETNKSLQKAEEELQELREKIAKGECGNSSLMAEVESLRKRVLEMEGKDEEITKTEAQCRELKKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSRSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKEYSLTKERDELMGKLRSEEERSCELSCSVDLLKKRLDGIEEVEREINRGRSCKGSEFTCPEDNKIRELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQMAKHKAIEKGEAVSQEAELRHRFRLEEAKSRDLQAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEETKNKNMGREVLNLTKELELSKRYSRALRPSGNGRRMVDVPVASTGVQTEAVCGDAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPMERSSVLDRYPPAANELTMRKSWIPWMRKRENGPSTPQEKGPRPNQGAGHPGELVLAPKQGQPLHIRVTPDHENSTATLEITSPTSEEFFSSTTVIPTLGNQKPRITIIPSPNVMSQKPKSADPTLGPERAMSPVTITTISREKSPEGGRSAFADRPASPIQIMTVSTSAAPTEIAVSPESQEVPMGRTILKVTPEKQTVPAPVRKYNSNANIITTEDNKIHIHLGSQFKRSPGPAAEGVSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITITPVTTSSTRGTQSVSGQDGSSQRPTPTRIPMSKGMKAGKPVVAASGAGNLTKFQPRAETQSMKIELKKSAASSTASLGGGKG
uniprot
proteins
function
FUNCTION: By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of Filamin A. {ECO:0000269|PubMed:12055638, ECO:0000269|PubMed:15794127}.
uniprot
proteins
mass_dalton
137753
uniprot
proteins
protein_family
FILIP1 family
uniprot
proteins
pubmed
12055638
uniprot
proteins
pubmed
15794127
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12055638, ECO:0000269|PubMed:15794127}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12055638}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:12055638}. Note=Localized along actin stress fibers, except at their ends, suggesting colocalization with F-actin (fiber-like). {ECO:0000269|PubMed:12055638}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12055638}. Note=Punctate distribution in the cytoplasm distinct from that of F-actin. {ECO:0000269|PubMed:12055638}.
uniprot
proteins