Ascc2
entrez
75452
canonical
uniprot
Q91WR3
canonical
ensembl
ENSMUSG00000020412
resolver
ensp
ENSMUSP00000063272
resolver
genesymbol
Ascc2
resolver
genesymbol_syn
Asc1p100
resolver
uniprot
Q5NCK1
resolver
uniprot
Q8BKM9
resolver
uniprot
Q8BX60
resolver
uniprot
Q8R1B9
resolver
uniprot_entry
ASCC2_MOUSE
resolver
uniprot_sec
Q5NCK1
resolver
uniprot_sec
Q8BKM9
resolver
uniprot_sec
Q8BX60
resolver
uniprot_sec
Q8R1B9
resolver
amino_acid_sequence
MPALPLDQLQITHKDPKTGQPKTSAALNPEQKADRYFVLYKPPPKDNIPALVEEYLERANFVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLHYVPRKFDEWVAPTPEVADMQNHLHRSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMIGNIFTQQPSYYTDLDETIPTILQVFSNILQHCGLQGDGTSTTPQKLGERSPLTPSDMPLLELKDIVLYLCDTSTTLWAFLDIFPLACQTFQKHDFCYRLASFYEMAIPELESAIKKRRLEDSKLLGDMWQRLSHSKKKLMEVFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQEKRFLRDYDTFSPVAEDISLLQQASSALDETRTAYILQAVESAWEGVDRQKIKDIKDPPRAKGSNNEVTVTAEPVSEMPSQLENLEEDEECMGAAAALGPAVSGVELDSLISQVKDLLPDLGEGFILACLEHYSYDSEQVINNILEDRLAPELSQLDRGLERQVKPDPTPLLSSRHNIFQNDEFDVFSRDSVDLSRVHKGRRKEENVRSLVNDKQAVVAQWQRYQKYSVVVEEVPLQPGEYQADDYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKMPGEVQEEEWDEEDEVEEEAPKPDHFIQDPAVLREKAEARRMAFLARKGYRPENSTAVTGGPRGHGQSRETTQERRKKEANKAARANHNRRTMADRKRSKGMIPS
uniprot
proteins
function
FUNCTION: Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes. Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes. {ECO:0000250|UniProtKB:Q9H1I8}.
uniprot
proteins
mass_dalton
85653
uniprot
proteins
protein_family
ASCC2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
749
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H1I8}. Nucleus speckle {ECO:0000250|UniProtKB:Q9H1I8}. Note=Colocalizes with the spliceosomal components PRPF8 and SNRNP200/BRR2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. Colocalizes with RNF113A and 'Lys-63'-linked polyubiquitinated proteins, ALKBH3 and ASCC3 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. {ECO:0000250|UniProtKB:Q9H1I8}.
uniprot
proteins