Clec4d
entrez
17474
canonical
uniprot
Q9Z2H6
canonical
ensembl
ENSMUSG00000030144
resolver
ensp
ENSMUSP00000032240
resolver
ensp
ENSMUSP00000352380
resolver
enst
ENSMUST00000032240
resolver
genesymbol
Clec4d
resolver
genesymbol_syn
Clecsf8
resolver
genesymbol_syn
Mcl
resolver
uniprot
Q3UBK0
resolver
uniprot
Q4KL29
resolver
uniprot
Q8C212
resolver
uniprot_entry
CLC4D_MOUSE
resolver
uniprot_entry
Q3UBK0_MOUSE
resolver
uniprot_entry
Q4KL29_MOUSE
resolver
uniprot_sec
Q8C212
resolver
amino_acid_sequence
MWLEESQMKSKGTRHPQLIPCVFAVVSISFLSACFISTCLVTHHYFLRWTRGSVVKLSDYHTRVTCIREEPQPGATGGTWTCCPVSWRAFQSNCYFPLNDNQTWHESERNCSGMSSHLVTINTEAEQNFVTQLLDKRFSYFLGLADENVEGQWQWVDKTPFNPHTVFWEKGESNDFMEEDCVVLVHVHEKWVWNDFPCHFEVRRICKLPGITFNWKPSK
uniprot
proteins
function
FUNCTION: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) (PubMed:23602766, PubMed:23911656). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766, PubMed:23911656). The heterodimer formed with CLEC6A is active against fungal infection (By similarity). Functions as an endocytic receptor (By similarity). May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (By similarity). {ECO:0000250|UniProtKB:Q69FH1, ECO:0000250|UniProtKB:Q8WXI8, ECO:0000269|PubMed:23602766, ECO:0000269|PubMed:23911656}.
uniprot
proteins
mass_dalton
25619
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23602766
uniprot
proteins
pubmed
23911656
uniprot
proteins
pubmed
9660840
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:23602766}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..43; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins