Cyp2c70
entrez
226105
canonical
uniprot
Q91W64
canonical
ensembl
ENSMUSG00000060613
resolver
ensp
ENSMUSP00000060584
resolver
enst
ENSMUST00000051846
resolver
genesymbol
Cyp2c70
resolver
genesymbol_syn
Cyp2c-70
resolver
genesymbol_syn
Cyp2c22
resolver
uniprot
Q5GLY9
resolver
uniprot
Q80VW0
resolver
uniprot
Q8R120
resolver
uniprot
Q8VC00
resolver
uniprot_entry
CP270_MOUSE
resolver
uniprot_sec
Q5GLY9
resolver
uniprot_sec
Q80VW0
resolver
uniprot_sec
Q8R120
resolver
uniprot_sec
Q8VC00
resolver
amino_acid_sequence
MALFIFLGIWLSCFLFLFLWNQHRGRGKLPPGPTPLPIVGNILQVDVKNISKSMGMLAKKYGPVFTVYLGMKPTVVLHGYKAMKEALIDQGDEFSDKTDSSLLSRTSQGLGIVFSNGETWKQTRRFSLMVLRSMGMGKKTIEDRIQEEILYMLDALRKTNGSPCDPSFLLACVPCNVISTVIFQHRFDYNDQTFQDFMENFHRKIEILASPWSQLCSAYPILYYLPGIHNRFLKDVTQQKKFILEEINRHQKSLDLSNPQDFIDYFLIKMEKEKHNQKSEFTMDNLVVSIGDLFGAGTETTSSTVKYGLLLLLKYPEVTAKIQEEIAHVIGRHRRPTMQDRNHMPYTDAVLHEIQRYIDFVPIPSPRKTTQDVEFRGYHIPKGTSVMACLTSVLNDDKEFPNPEKFDPGHFLDEKGNFKKSDYFVAFSAGRRACIGEGLARMEMFLILTNILQHFTLKPLVKPEDIDTKPVQTGLLHVPPPFELCFIPV
uniprot
proteins
ec_number
1.14.14.-
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in muricholic acid (MCA) synthesis (PubMed:27638959). Hydroxylates at the 6-beta position two major bile acids, chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) to form alpha-MCA and beta-MCA, respectively (PubMed:27638959). May regulate NR1H4/farnesoid X receptor signaling, as taurine-conjugated MCAs are antagonists of NR1H4. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:27638959). {ECO:0000269|PubMed:27638959}.
uniprot
proteins
mass_dalton
56020
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27638959
uniprot
proteins
sequence_length
489
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
uniprot
proteins