TFG
entrez
10342
canonical
uniprot
Q92734
canonical
ensembl
ENSG00000114354
resolver
ensp
ENSP00000240851
resolver
ensp
ENSP00000417952
resolver
ensp
ENSP00000419504
resolver
ensp
ENSP00000419960
resolver
ensp
ENSP00000420797
resolver
ensp
ENSP00000501815
resolver
ensp
ENSP00000502071
resolver
ensp
ENSP00000502497
resolver
ensp
ENSP00000502698
resolver
ensp
ENSP00000543502
resolver
ensp
ENSP00000642428
resolver
genesymbol
TFG
resolver
hgnc
HGNC:11758
resolver
uniprot
D3DN49
resolver
uniprot
G5E9V1
resolver
uniprot
K0J5S8
resolver
uniprot
K0J6K2
resolver
uniprot
Q05BK6
resolver
uniprot
Q15656
resolver
uniprot
Q969I2
resolver
uniprot_entry
Q05BK6_HUMAN
resolver
uniprot_entry
TFG_HUMAN
resolver
uniprot_sec
D3DN49
resolver
uniprot_sec
G5E9V1
resolver
uniprot_sec
K0J5S8
resolver
uniprot_sec
K0J6K2
resolver
uniprot_sec
Q15656
resolver
uniprot_sec
Q969I2
resolver
amino_acid_sequence
MNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKLTLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDEINKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEGQMYQQYQQQAGYGAQQPQAPPQQPQQYGIQYSASYSQQTGPQQPQQFQGYGQQPTSQAPAPAFSGQPQQLPAQPPQQYQASNYPAQTYTAQTSQPTNYTVAPASQPGMAPSQPGAYQPRPGFTSLPGSTMTPPPSGPNPYARNRPPFGQGYTQPGPGYR
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving TFG is found in papillary thyroid carcinomas (PTCs). Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript. {ECO:0000269|PubMed:7565764}.; DISEASE: Neuropathy, hereditary motor and sensory, Okinawa type (HMSNO) [MIM:604484]: A neurodegenerative disorder characterized by young adult onset of proximal muscle weakness and atrophy, muscle cramps, and fasciculations, with later onset of distal sensory impairment. The disorder is slowly progressive and clinically resembles amyotrophic lateral sclerosis. {ECO:0000269|PubMed:22883144, ECO:0000269|PubMed:27813252}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Spastic paraplegia 57, autosomal recessive (SPG57) [MIM:615658]: A complicated form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. Complicated forms are recognized by additional variable features including spastic quadriparesis, seizures, dementia, amyotrophy, extrapyramidal disturbance, cerebral or cerebellar atrophy, optic atrophy, and peripheral neuropathy, as well as by extra neurological manifestations. {ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27492651, ECO:0000269|PubMed:27813252, ECO:0000269|PubMed:30237576}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}.
uniprot
proteins
mass_dalton
43448
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21478858
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22883144
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23479643
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27492651
uniprot
proteins
pubmed
27813252
uniprot
proteins
pubmed
30237576
uniprot
proteins
pubmed
7565764
uniprot
proteins
pubmed
9169129
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:27813252}. Note=Localizes to endoplasmic reticulum exit site (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:21478858, PubMed:27813252). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:27813252}.
uniprot
proteins