Erbin
entrez
59079
canonical
uniprot
Q80TH2
canonical
ensembl
ENSMUSG00000021709
resolver
ensp
ENSMUSP00000088813
resolver
ensp
ENSMUSP00000127607
resolver
ensp
ENSMUSP00000140536
resolver
ensp
ENSMUSP00000140931
resolver
enst
ENSMUST00000169083
resolver
enst
ENSMUST00000188997
resolver
genesymbol
Erbin
resolver
genesymbol_syn
Erbb2ip
resolver
genesymbol_syn
Kiaa1225
resolver
genesymbol_syn
Lap2
resolver
uniprot
A0A087WS77
resolver
uniprot
B2RUJ2
resolver
uniprot
B2RUK2
resolver
uniprot
B7ZNX6
resolver
uniprot
E9QND6
resolver
uniprot
F6T1F2
resolver
uniprot
Q8BQ14
resolver
uniprot
Q8CE41
resolver
uniprot
Q8K171
resolver
uniprot
Q99JU3
resolver
uniprot
Q9JI47
resolver
uniprot_entry
A0A087WS77_MOUSE
resolver
uniprot_entry
B2RUJ2_MOUSE
resolver
uniprot_entry
B2RUK2_MOUSE
resolver
uniprot_entry
B7ZNX6_MOUSE
resolver
uniprot_entry
ERBIN_MOUSE
resolver
uniprot_entry
F6T1F2_MOUSE
resolver
uniprot_sec
E9QND6
resolver
uniprot_sec
Q8BQ14
resolver
uniprot_sec
Q8CE41
resolver
uniprot_sec
Q8K171
resolver
uniprot_sec
Q99JU3
resolver
uniprot_sec
Q9JI47
resolver
amino_acid_sequence
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLREFWMDGNRLTFIPGFIGSLRQLTYLDVSKNNIEMVEEGISTCENLQDFLLSSNSLQQLPETIGSLKNVTTLKIDENQLMYLPDSIGGLRSIEELDCSFNEIEALPSSIGQLTNMRTFAADHNYLQQLPPEIGNWKNITVLFLHCNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDTETQKMVLTNYMFPQQPRTEDVMFISDNESFNPALWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEESGRDLKQHEDQQVVNKDKCVKTSESTTTKSKLDEREKYMNSVQKMSEPEAETNGGNLPVTASMKLSGNLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIESSINQPKVVALSNNKKDDAKDADSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTPVDSNSKVRQEDENFNSLLQNGVNLNNSPEEKFKINDKKDFKLPEYDLNIEEQLVLIEKDIDSKATSDDSRQLDHINMNINKLVTNNIFQPEVMERSKMQDIVLGTGFLSIHPKNEAEHIENGAKFPNLESINKVNGLCEDTAPSPGRVEPQKASSSADVGISKSTEDLSPQRSGPTGAVVKSHSITNMETGGLKIYDILGDDGPQPPSAAVKIASAVDGKNIVRSKSATLLYDQPLQVFTAASSSSELLSGTKAVFKFDSNHNPEEPDIIRAATVSGPQSTPHLYGPPQYNVQYSGSATVKDTLWHPKQNPQIDPVSFPPQRLPRSESAENHSYAKHSANMNFSNHNNVRANTGYHLQQRLAPARHGEMWAISPNDRLVPAVTRTTIQRQSSVSSTASVNLGDPTRRTEGDYLSYRELHSMGRTPVMSGSQRPLSARAYSIDGPNTSRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNTRVGSEHSLLDPPGKSKVPHDWREQVLRHIEAKKLEKHPQTSSPGECCQDDRFMSEEQNHPSGALSHRGLPDSLMKMPLSNGQMGQPLRPQAHYSQTHHPPQASVARHPSREQLIDYLMLKVAHQPPYTHPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFHNAVDLIIVREVSS
uniprot
proteins
function
FUNCTION: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state (By similarity). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). Acts as a mediator of keratinocyte differentiation by sequestering SHOC2 away from ERK-activating RAS complexes (By similarity). {ECO:0000250|UniProtKB:Q96RT1, ECO:0000269|PubMed:16203728}.
uniprot
proteins
mass_dalton
157248
uniprot
proteins
mutagenesis
MUTAGEN 315; /note="P->L: Decreases interaction with NOD2."; /evidence="ECO:0000269|PubMed:16203728
uniprot
proteins
post_translational_modification
PTM: Isoform 2 is phosphorylated on Ser-1231 and Ser-1234.
uniprot
proteins
protein_family
LAP (LRR and PDZ) protein family
uniprot
proteins
pubmed
10878805
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16203728
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
18802028
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1402
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, hemidesmosome {ECO:0000250|UniProtKB:Q96RT1}. Nucleus membrane {ECO:0000269|PubMed:18802028}. Basolateral cell membrane {ECO:0000269|PubMed:16203728}. Cytoplasm {ECO:0000250|UniProtKB:Q96RT1}. Cell membrane {ECO:0000250|UniProtKB:Q96RT1}. Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane (By similarity). Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000250|UniProtKB:Q96RT1}.
uniprot
proteins