Chmp4c
entrez
66371
canonical
uniprot
Q9D7F7
canonical
ensembl
ENSMUSG00000027536
resolver
ensp
ENSMUSP00000029049
resolver
enst
ENSMUST00000029049
resolver
genesymbol
Chmp4c
resolver
uniprot
Q149R2
resolver
uniprot
Q3TVD7
resolver
uniprot
Q9CWH8
resolver
uniprot_entry
CHM4C_MOUSE
resolver
uniprot_sec
Q149R2
resolver
uniprot_sec
Q3TVD7
resolver
uniprot_sec
Q9CWH8
resolver
amino_acid_sequence
MSKLGKFFKGTRSSRARAAPSAQEALARLRETEEMLAKKQEYLENRIQRELALAKKHGSQNKRAALQALKRKKRFEKQLTQVDGTLSTIEFQREALENSHTNTEVLRNMGFAAKAMKAVHDNMDLNKIDDLMQDITEQQDIAQEISEAFSQRVQFADGFDEAELLAELEELEQEELNKKMTSLELPNVPSSSLPAQPSRKASMPSSVHRSRAASSRRAEEDDDFKQLAAWAT
uniprot
proteins
function
FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). {ECO:0000250|UniProtKB:Q96CF2}.
uniprot
proteins
mass_dalton
26280
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-210 by AURKB during cytokinesis: together with ZFYVE19/ANCHR, phosphorylated CHMP4C retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. {ECO:0000250|UniProtKB:Q96CF2}.
uniprot
proteins
protein_family
SNF7 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
232
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Late endosome membrane {ECO:0000250|UniProtKB:Q96CF2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96CF2}. Midbody, Midbody ring {ECO:0000250|UniProtKB:Q96CF2}. Note=Localizes to the midbody during late cytokinesis. During its recruitment, localizes initially to the midbody arms, before being directed to the central region, the midbody ring, also called Flemming body. Phosphorylation at Ser-210 by AURKB triggers localization to midbody ring. {ECO:0000250|UniProtKB:Q96CF2}.
uniprot
proteins