Slc27a2
entrez
65192
canonical
uniprot
P97524
canonical
ensembl
ENSRNOG00000010128
resolver
ensembl
ENSRNOG00055005204
resolver
ensembl
ENSRNOG00060014106
resolver
ensembl
ENSRNOG00065012788
resolver
ensp
ENSRNOP00000059771
resolver
ensp
ENSRNOP00055006326
resolver
ensp
ENSRNOP00060019266
resolver
ensp
ENSRNOP00065016092
resolver
enst
ENSRNOT00000067700
resolver
enst
ENSRNOT00055008357
resolver
enst
ENSRNOT00060024150
resolver
enst
ENSRNOT00065020888
resolver
genesymbol
Slc27a2
resolver
genesymbol_syn
Acsvl1
resolver
genesymbol_syn
Facvl1
resolver
genesymbol_syn
Fatp2
resolver
genesymbol_syn
Vlacs
resolver
genesymbol_syn
Vlcs
resolver
uniprot
A0ACM8Q5K1
resolver
uniprot
D3ZSL9
resolver
uniprot
Q66HN6
resolver
uniprot_entry
A0ACM8Q5K1_RAT
resolver
uniprot_entry
Q66HN6_RAT
resolver
uniprot_entry
S27A2_RAT
resolver
uniprot_sec
D3ZSL9
resolver
amino_acid_sequence
MLPVLYTGLAGLLLLPLLLTCCCPYLLQDVRFFLQLANMARQVRSYRQRRPVRTILHVFLEQARKTPHKPFLLFRDETLTYAQVDRRSNQVARALHDHLGLRQGDCVALFMGNEPAYVWLWLGLLKLGCPMACLNYNIRAKSLLHCFQCCGAKVLLASPELHEAVEEVLPTLKKEGVSVFYVSRTSNTNGVDTVLDKVDGVSADPIPESWRSEVTFTTPAVYIYTSGTTGLPKAATINHHRLWYGTSLALRSGIKAHDVIYTTMPLYHSAALMIGLHGCIVVGATFALRSKFSASQFWDDCRKYNATVIQYIGELLRYLCNTPQKPNDRDHKVKIALGNGLRGDVWREFIKRFGDIHIYEFYASTEGNIGFMNYPRKIGAVGRENYLQKKVVRHELIKYDVEKDEPVRDANGYCIKVPKGEVGLLICKITELTPFFGYAGGKTQTEKKKLRDVFKKGDVYFNSGDLLMIDRENFIYFHDRVGDTFRWKGENVATTEVADIVGLVDFVEEVNVYGVPVPGHEGRIGMASIKMKENYEFNGKKLFQHISEYLPSYSRPRFLRIQDTIEITGTFKHRKVTLMEEGFNPSVIKDTLYFMDDTEKTYVPMTEDIYNAIIDKTLKL
uniprot
proteins
ec_number
6.2.1.-
uniprot
proteins
ec_number
6.2.1.15
uniprot
proteins
ec_number
6.2.1.24
uniprot
proteins
ec_number
6.2.1.3
uniprot
proteins
ec_number
6.2.1.7
uniprot
proteins
function
FUNCTION: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (By similarity). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:10640429, PubMed:8939997). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:10640429, PubMed:8939997). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (By similarity). May contribute to the synthesis of sphingosine-1-phosphate (By similarity). Does not activate C24 bile acids, cholate and chenodeoxycholate. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. However, it is not critical for THCA activation and bile synthesis in vivo (By similarity). {ECO:0000250|UniProtKB:O14975, ECO:0000269|PubMed:10640429, ECO:0000269|PubMed:8939997}.
uniprot
proteins
mass_dalton
70694
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
10640429
uniprot
proteins
pubmed
8939997
uniprot
proteins
sequence_length
620
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10640429}; Multi-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000269|PubMed:10640429, ECO:0000269|PubMed:8939997}; Peripheral membrane protein {ECO:0000269|PubMed:10640429}. Cell membrane {ECO:0000250|UniProtKB:O35488}; Multi-pass membrane protein {ECO:0000255}. Microsome {ECO:0000269|PubMed:10640429, ECO:0000269|PubMed:8939997}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..27; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 107..127; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 268..288; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins