Hrh1
entrez
15465
canonical
uniprot
P70174
canonical
ensembl
ENSMUSG00000053004
resolver
ensp
ENSMUSP00000086383
resolver
ensp
ENSMUSP00000124037
resolver
ensp
ENSMUSP00000124320
resolver
ensp
ENSMUSP00000124460
resolver
ensp
ENSMUSP00000238509
resolver
ensp
ENSMUSP00000238512
resolver
ensp
ENSMUSP00000238516
resolver
enst
ENSMUST00000088987
resolver
enst
ENSMUST00000160780
resolver
enst
ENSMUST00000161220
resolver
enst
ENSMUST00000161650
resolver
genesymbol
Hrh1
resolver
genesymbol_syn
Bphs
resolver
uniprot
B3Y5T0
resolver
uniprot
Q91V75
resolver
uniprot
Q91XN0
resolver
uniprot
Q91XN1
resolver
uniprot
Q91XN2
resolver
uniprot
Q91XN3
resolver
uniprot_entry
B3Y5T0_MOUSE
resolver
uniprot_entry
HRH1_MOUSE
resolver
uniprot_sec
Q91V75
resolver
uniprot_sec
Q91XN0
resolver
uniprot_sec
Q91XN1
resolver
uniprot_sec
Q91XN2
resolver
uniprot_sec
Q91XN3
resolver
amino_acid_sequence
MSLPNTSSASEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFLSFLWVIPILGWHHFTPLAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPTFLEIKLRSEDAKEGAKKPGKESPWGVQKRPSRDPTGGLDQKSTSEDPKVTSPTVFSQEGERETVTRPCFRLDVMQTQPVPEGDARGSKANDQTLSQPKMDEQSLSTCRRISETSEDQTLVDRQSFSRTTDSDTSIEPGLGKVKARSRSNSGLDYIKVTWKRLRSHSRQYVSGLHLNRERKAAKQLGCIMAAFILCWIPYFIFFMVIAFCNSCCSEPVHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (By similarity). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules (PubMed:12595443). Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (PubMed:17145090, PubMed:8917588). {ECO:0000250|UniProtKB:P35367, ECO:0000269|PubMed:12595443, ECO:0000269|PubMed:17145090, ECO:0000269|PubMed:8917588}.
uniprot
proteins
mass_dalton
55682
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor down-regulation. {ECO:0000250|UniProtKB:P35367}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12142541
uniprot
proteins
pubmed
12595443
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17145090
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8812432
uniprot
proteins
pubmed
8917588
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8917588}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P35367}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P35367"; TRANSMEM 65..89; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P35367"; TRANSMEM 98..123; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P35367"; TRANSMEM 145..164; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P35367"; TRANSMEM 189..211; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P35367"; TRANSMEM 418..441; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P35367"; TRANSMEM 448..470; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P35367
uniprot
proteins