ACHE
entrez
43
canonical
uniprot
P22303
canonical
ensembl
ENSG00000087085
resolver
ensp
ENSP00000241069
resolver
ensp
ENSP00000403474
resolver
ensp
ENSP00000404865
resolver
ensp
ENSP00000414858
resolver
ensp
ENSP00000564969
resolver
ensp
ENSP00000602326
resolver
genesymbol
ACHE
resolver
hgnc
HGNC:108
resolver
uniprot
A4D2E2
resolver
uniprot
B7ZKZ0
resolver
uniprot
D6W5X7
resolver
uniprot
Q16169
resolver
uniprot
Q29S23
resolver
uniprot
Q2M324
resolver
uniprot
Q504V3
resolver
uniprot
Q53F46
resolver
uniprot
Q86TM9
resolver
uniprot
Q86YX9
resolver
uniprot
Q9BXP7
resolver
uniprot_entry
ACES_HUMAN
resolver
uniprot_sec
A4D2E2
resolver
uniprot_sec
B7ZKZ0
resolver
uniprot_sec
D6W5X7
resolver
uniprot_sec
Q16169
resolver
uniprot_sec
Q29S23
resolver
uniprot_sec
Q2M324
resolver
uniprot_sec
Q504V3
resolver
uniprot_sec
Q53F46
resolver
uniprot_sec
Q86TM9
resolver
uniprot_sec
Q86YX9
resolver
uniprot_sec
Q9BXP7
resolver
amino_acid_sequence
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
uniprot
proteins
ec_number
3.1.1.7
uniprot
proteins
function
FUNCTION: Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis. {ECO:0000269|PubMed:11985878, ECO:0000269|PubMed:1517212, ECO:0000269|PubMed:1748670, ECO:0000269|PubMed:2714437}.
uniprot
proteins
mass_dalton
67796
uniprot
proteins
mutagenesis
MUTAGEN 206; /note="D->N: Misfolding, absence of secretion."; /evidence="ECO:0000269|PubMed:1517212"; MUTAGEN 234; /note="S->A: Loss of activity."; /evidence="ECO:0000269|PubMed:1517212"; MUTAGEN 365; /note="E->A: Loss of activity."; /evidence="ECO:0000269|PubMed:1517212"; MUTAGEN 435; /note="D->N: Misfolding, absence of secretion."; /evidence="ECO:0000269|PubMed:1517212"; MUTAGEN 478; /note="H->A: Loss of activity."; /evidence="ECO:0000269|PubMed:1517212"; MUTAGEN 611; /note="C->A: Impairment of interchain disulfide bridge formation."; /evidence="ECO:0000269|PubMed:1748670
uniprot
proteins
protein_family
Type-B carboxylesterase/lipase family
uniprot
proteins
pubmed
11053835
uniprot
proteins
pubmed
11239002
uniprot
proteins
pubmed
11985878
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1517212
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15526038
uniprot
proteins
pubmed
1748670
uniprot
proteins
pubmed
20408548
uniprot
proteins
pubmed
2263619
uniprot
proteins
pubmed
23035744
uniprot
proteins
pubmed
23679855
uniprot
proteins
pubmed
2714437
uniprot
proteins
pubmed
8299725
uniprot
proteins
pubmed
8488842
uniprot
proteins
pubmed
9640563
uniprot
proteins
sequence_length
614
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000269|PubMed:11985878, ECO:0000269|PubMed:1748670}. Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform T]: Nucleus. Note=Only observed in apoptotic nuclei.; SUBCELLULAR LOCATION: [Isoform H]: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.
uniprot
proteins