Mtf2
entrez
17765
canonical
uniprot
Q02395
canonical
ensembl
ENSMUSG00000029267
resolver
ensp
ENSMUSP00000080278
resolver
ensp
ENSMUSP00000326811
resolver
genesymbol
Mtf2
resolver
genesymbol_syn
Pcl2
resolver
uniprot
Q05C61
resolver
uniprot
Q569Z8
resolver
uniprot
Q6PG89
resolver
uniprot
Q8BGP9
resolver
uniprot
Q8BSJ7
resolver
uniprot_entry
MTF2_MOUSE
resolver
uniprot_sec
Q05C61
resolver
uniprot_sec
Q569Z8
resolver
uniprot_sec
Q6PG89
resolver
uniprot_sec
Q8BGP9
resolver
uniprot_sec
Q8BSJ7
resolver
amino_acid_sequence
MRDSTGAGNSLVHKRSPLRRNQKTSASLNKLSLQDGHKAKKPACKFEEGQDVLARWSDGLFYLGTIKKINILKQSCFIIFEDSSKSWVLWKDIQTGATGSGEMVCTICQEEYSEAPNEMVICDKCGQGYHQLCHTPHIDSSVIDSDEKWLCRQCVFATTTKRGGALKKGPNAKALQVMKQTLPYSVADLEWDAGHKTNVQQCYCYCGGPGDWYLKMLQCCKCKQWFHEACVQCLQKPMLFGDRFYTFICSVCSSGPEYLKRLPLQWVDIAHLCLYNLSVIHKKKYFDSELELMTYINENWDRLHPGELADTPKSERYEHVLEALNDYKTMFMSGKEIKKKKHLFGLRIRVPPVPPNVAFKAEKEPEGTSHEFKIKGRKASKPTSDSREVSNGIEKKGKKKSVGRPPGPYTRKMIQKTAELPLDKESVSENPTLDLPCSIGRTEGIAHSSNTSDVDLTGASSANETTSASISRHCGLSDSRKRTRTGRSWPAAIPHLRRRRGRLPRRALQTQNSEVVKDDEGKEDYQFEELNTEILNNLADQELQLNHLKNSITSYFGAAGRIACGEKYRVLARRVTLDGKVQYLVEWEGATAS
uniprot
proteins
function
FUNCTION: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:20144788, PubMed:21059868, PubMed:21367819, PubMed:22438827, PubMed:23104054). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (PubMed:20144788). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (PubMed:21367819). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (PubMed:21059868). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (PubMed:21059868). Binds to the metal-regulating-element (MRE) of MT1A gene promoter (PubMed:7772254). {ECO:0000269|PubMed:20144788, ECO:0000269|PubMed:21059868, ECO:0000269|PubMed:21367819, ECO:0000269|PubMed:22438827, ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:7772254}.
uniprot
proteins
mass_dalton
66924
uniprot
proteins
protein_family
Polycomblike family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20144788
uniprot
proteins
pubmed
21059868
uniprot
proteins
pubmed
21367819
uniprot
proteins
pubmed
22438827
uniprot
proteins
pubmed
23104054
uniprot
proteins
pubmed
7772254
uniprot
proteins
pubmed
9173905
uniprot
proteins
sequence_length
593
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21367819}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000269|PubMed:21367819}.
uniprot
proteins