ATP6V1C1
entrez
528
canonical
uniprot
P21283
canonical
ensembl
ENSG00000155097
resolver
ensp
ENSP00000379203
resolver
ensp
ENSP00000430282
resolver
ensp
ENSP00000624129
resolver
ensp
ENSP00000624130
resolver
enst
ENST00000395862
resolver
enst
ENST00000518738
resolver
enst
ENST00000954070
resolver
enst
ENST00000954071
resolver
genesymbol
ATP6V1C1
resolver
genesymbol_syn
ATP6C
resolver
genesymbol_syn
ATP6D
resolver
genesymbol_syn
VATC
resolver
hgnc
HGNC:856
resolver
uniprot
A0A024R9I0
resolver
uniprot_entry
A0A024R9I0_HUMAN
resolver
uniprot_entry
VATC1_HUMAN
resolver
amino_acid_sequence
MTEFWLISAPGEKTCQQTWEKLHAATSKNNNLAVTSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLANGVDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVTQIDNDLKSRASAYNNLKGNLQNLERKNAGSLLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDWIKQYETLAEMVVPRSSNVLSEDQDSYLCNVTLFRKAVDDFRHKARENKFIVRDFQYNEEEMKADKEEMNRLSTDKKKQFGPLVRWLKVNFSEAFIAWIHVKALRVFVESVLRYGLPVNFQAMLLQPNKKTLKKLREVLHELYKHLDSSAAAIIDAPMDIPGLNLSQQEYYPYVYYKIDCNLLEFK
uniprot
proteins
function
FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (PubMed:22053050). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). {ECO:0000250|UniProtKB:P21282, ECO:0000250|UniProtKB:P31412, ECO:0000269|PubMed:22053050, ECO:0000269|PubMed:33065002}.
uniprot
proteins
mass_dalton
43942
uniprot
proteins
protein_family
V-ATPase C subunit family
uniprot
proteins
pubmed
11707601
uniprot
proteins
pubmed
12384298
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2147024
uniprot
proteins
pubmed
22053050
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
33065002
uniprot
proteins
pubmed
8250920
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q5FVI6}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q5FVI6}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins