Fam20c
entrez
80752
canonical
uniprot
Q5MJS3
canonical
ensembl
ENSMUSG00000025854
resolver
ensp
ENSMUSP00000026972
resolver
enst
ENSMUST00000026972
resolver
genesymbol
Fam20c
resolver
genesymbol_syn
Dmp4
resolver
genesymbol_syn
Kiaa4081
resolver
uniprot
Q4FJP0
resolver
uniprot
Q571A3
resolver
uniprot
Q6PKA8
resolver
uniprot
Q8JZP7
resolver
uniprot_entry
FA20C_MOUSE
resolver
uniprot_sec
Q4FJP0
resolver
uniprot_sec
Q571A3
resolver
uniprot_sec
Q6PKA8
resolver
uniprot_sec
Q8JZP7
resolver
activity_regulation
ACTIVITY REGULATION: Serine/threonine protein kinase activity is increased upon interaction with FAM20A. {ECO:0000269|PubMed:25789606}.
uniprot
proteins
amino_acid_sequence
MKMILVRRFRVLILVVFLLACALHIAVDLLPKLDRRATRSSGEPGCSCAQPAAEAAGPGWAQARSRPGESAGGDAGWPNKHTLRILQDFSSDPASNLTSHSLEKLPSAAEPVDHAPRGQEPRSPPPRDPAHRPLLRDPGPRPRVPPPGPSGDGSLLAKLFEHPLYQGAVPPLTEDDVLFNVNSDIRFNPKAAENPDWPHEGAEGAEFLPTGEAAVNLYPNWLKFHIGINRYELYSRHNPAIDALLRDLGSQKITSVAMKSGGTQLKLIMTFQNYGQALFKPMKQTREQETPPDFFYFSDYERHNAEIAAFHLDRILDFRRVPPVAGRMINMTKEIRDVTRDKKLWRTFFVSPANNICFYGECSYYCSTEHALCGRPDQIEGSLAAFLPDLSLAKRKTWRNPWRRSYHKRKKAEWEVDPDYCEEVKQTPPYDSGHRILDIMDMTVFDFLMGNMDRHHYETFEKFGNETFIIHLDNGRGFGKYSHDELSILAPLHQCCRIRRSTYLRLQLLAKEEHKLSLLMAESLQHDKVAPVLYQLHLEALDRRLRIVLQAVRDCVEKDGLSSVVEDDLATEHRASTER
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22732358, PubMed:22900076, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (By similarity). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (By similarity). Phosphorylates ERO1A, enhancing its activity which is required to maintain endoplasmic reticulum redox homeostasis and for oxidative protein folding (By similarity). During endoplasmic reticulum stress, phosphorylates P4HB/PDIA1 which induces a functional switch, causing P4HB to change from an oxidoreductase to a molecular chaperone (By similarity). This is critical to maintain ER proteostasis and reduce cell death under ER stress (By similarity). Phosphorylation of P4HB also promotes its interaction with ERN1, leading to reduced activity of ERN1, a key sensor for the endoplasmic reticulum unfolded protein response (By similarity). Required for osteoblast differentiation and mineralization (By similarity). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (By similarity). {ECO:0000250|UniProtKB:Q8IXL6, ECO:0000269|PubMed:22732358, ECO:0000269|PubMed:22900076, ECO:0000269|PubMed:25789606}.
uniprot
proteins
mass_dalton
65766
uniprot
proteins
mutagenesis
MUTAGEN 241; /note="I->N: Abrogates kinase activity."; /evidence="ECO:0000269|PubMed:22900076"; MUTAGEN 261; /note="G->R: Abrogates kinase activity."; /evidence="ECO:0000269|PubMed:22900076"; MUTAGEN 374; /note="G->E,R: Abrogates kinase activity."; /evidence="ECO:0000269|PubMed:22900076"; MUTAGEN 383; /note="L->R: Mislocalization of the protein from Golgi apparatus to endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:22900076"; MUTAGEN 446; /note="D->N: Mislocalization of the protein from Golgi apparatus to endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:22900076"; MUTAGEN 453; /note="D->G: Abrogates kinase activity without affecting subcellular location."; /evidence="ECO:0000269|PubMed:22900076"; MUTAGEN 473..474; /note="DN->GG: Abrogates kinase activity."; /evidence="ECO:0000269|PubMed:22900076"; MUTAGEN 544; /note="R->W: Mislocalization of the protein from Golgi apparatus to endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:22900076
uniprot
proteins
post_translational_modification
PTM: N-glycosylation is required for folding. {ECO:0000250|UniProtKB:Q8IXL6}.; PTM: Autophosphorylated. {ECO:0000250|UniProtKB:Q8IXL6}.; PTM: Propeptide cleavage by MBTPS1/S1P promotes FAM20C secretion and maximal kinase activity which is essential for efficient osteoblast differentiation and biomineralization. {ECO:0000250|UniProtKB:Q8IXL6}.
uniprot
proteins
protein_family
FAM20 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17369251
uniprot
proteins
pubmed
21549343
uniprot
proteins
pubmed
22732358
uniprot
proteins
pubmed
22900076
uniprot
proteins
pubmed
25789606
uniprot
proteins
pubmed
29858230
uniprot
proteins
sequence_length
579
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8IXL6}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8IXL6}. Secreted {ECO:0000269|PubMed:17369251}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8IXL6}. Note=Resides in the Golgi apparatus membrane and is secreted following propeptide cleavage. Retained in the endoplasmic reticulum (ER) in response to ER stress where it phosphorylates P4HB. {ECO:0000250|UniProtKB:Q8IXL6}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins