PVRIG
entrez
79037
canonical
uniprot
Q6DKI7
canonical
ensembl
ENSG00000213413
resolver
ensp
ENSP00000316675
resolver
ensp
ENSP00000514123
resolver
enst
ENST00000317271
resolver
enst
ENST00000699088
resolver
genesymbol
PVRIG
resolver
genesymbol_syn
C7orf15
resolver
hgnc
HGNC:32190
resolver
uniprot
A0A8V8TN58
resolver
uniprot
D6W5U9
resolver
uniprot
Q9BVK3
resolver
uniprot_entry
A0A8V8TN58_HUMAN
resolver
uniprot_entry
PVRIG_HUMAN
resolver
uniprot_sec
D6W5U9
resolver
uniprot_sec
Q9BVK3
resolver
amino_acid_sequence
MRTEAQVPALQPPEPGLEGAMGHRTLVLPWVLLTLCVTAGTPEVWVQVRMEATELSSFTIRCGFLGSGSISLVTVSWGGPNGAGGTTLAVLHPERGIRQWAPARQARWETQSSISLILEGSGASSPCANTTFCCKFASFPEGSWEACGSLPPSSDPGLSAPPTPAPILRADLAGILGVSGVLLFGCVYLLHLLRRHKHRPAPRLQPSRTSPQAPRARAWAPSQASQAALHVPYATINTSCRPATLDTAHPHGGPSWWASLPTHAAHRPQGPAAWASTPIPARGSFVSVENGLYAQAGERPPHTGPGLTLFPDPRGPRAMEGPLGVR
uniprot
proteins
function
FUNCTION: Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. {ECO:0000269|PubMed:26755705}.
uniprot
proteins
mass_dalton
34344
uniprot
proteins
mutagenesis
MUTAGEN 233; /note="Y->F: Reduced phosphorylation."; /evidence="ECO:0000269|PubMed:26755705"; MUTAGEN 293; /note="Y->F: No effect on global phosphorylation."; /evidence="ECO:0000269|PubMed:26755705
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16926269
uniprot
proteins
pubmed
26755705
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26755705}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..78; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins