Arg2
entrez
11847
canonical
uniprot
O08691
canonical
ensembl
ENSMUSG00000021125
resolver
ensp
ENSMUSP00000021550
resolver
enst
ENSMUST00000021550
resolver
genesymbol
Arg2
resolver
uniprot_entry
ARGI2_MOUSE
resolver
amino_acid_sequence
MFLRSSASRLLHGQIPCVLTRSVHSVAIVGAPFSRGQKKLGVEYGPAAIREAGLLKRLSRLGCHLKDFGDLSFTNVPQDDPYNNLVVYPRSVGLANQELAEVVSRAVSGGYSCVTMGGDHSLAIGTIIGHARHRPDLCVIWVDAHADINTPLTTVSGNIHGQPLSFLIKELQDKVPQLPGFSWIKPCLSPPNIVYIGLRDVEPPEHFILKNYDIQYFSMREIDRLGIQKVMEQTFDRLIGKRQRPIHLSFDIDAFDPKLAPATGTPVVGGLTYREGVYITEEIHNTGLLSALDLVEVNPHLATSEEEAKATARLAVDVIASSFGQTREGGHIVYDHLPTPSSPHESENEECVRI
uniprot
proteins
ec_number
3.5.3.1
uniprot
proteins
function
FUNCTION: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:25009204, PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (PubMed:27074721). May play a role in promoting prenatal immune suppression (By similarity). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (By similarity). {ECO:0000250|UniProtKB:P78540, ECO:0000269|PubMed:22928666, ECO:0000269|PubMed:25009204, ECO:0000269|PubMed:25484082, ECO:0000269|PubMed:27074721, ECO:0000269|PubMed:27214549, ECO:0000269|PubMed:27745970}.
uniprot
proteins
mass_dalton
38878
uniprot
proteins
mutagenesis
MUTAGEN 160; /note="H->F: Catalytically inactive; defective in promoting NOS3/eNOS-uncoupling in endothelial cells.
uniprot
proteins
pathway_participation
PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. {ECO:0000250|UniProtKB:P05089}.
uniprot
proteins
protein_family
Arginase family
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22928666
uniprot
proteins
pubmed
25009204
uniprot
proteins
pubmed
25484082
uniprot
proteins
pubmed
27074721
uniprot
proteins
pubmed
27214549
uniprot
proteins
pubmed
27745970
uniprot
proteins
pubmed
9608538
uniprot
proteins
pubmed
9745037
uniprot
proteins
pubmed
9814991
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25009204}.
uniprot
proteins