Hyal3
entrez
109685
canonical
uniprot
Q8VEI3
canonical
ensembl
ENSMUSG00000036091
resolver
ensp
ENSMUSP00000042667
resolver
ensp
ENSMUSP00000119499
resolver
enst
ENSMUST00000040059
resolver
enst
ENSMUST00000148440
resolver
genesymbol
Hyal3
resolver
genesymbol_syn
Hyl3
resolver
uniprot
B1AV95
resolver
uniprot
Q8VBX7
resolver
uniprot
Q8VI77
resolver
uniprot_entry
HYAL3_MOUSE
resolver
uniprot_sec
B1AV95
resolver
uniprot_sec
Q8VBX7
resolver
uniprot_sec
Q8VI77
resolver
amino_acid_sequence
MIMHLGLMMVVGLTLCLMHGQALLQVPEHPFSVVWNVPSARCKAHFGVHLPLDALGIVANHGQHFHGQNISIFYKNQFGLYPYFGPRGTAHNGGIPQAVSLDHHLARAAHQILHSLGSSFAGLAVLDWEEWYPLWAGNWGPHRQVYLAASWVWTQQMFPGLDPQEQLHKAHTSFEQAARALMEYTLQLGRTLRPSGLWGFYRYPACGNGWHKMASNYTGHCHAAITTRNTQLRWLWAASSALFPSIYLPPRLPLAYRQAFVRHRLEEAFRVALLEHSHPLPVLAYSRLTHRSSGRFLSLDDLMQTIGVSAALGTAGVVLWGDLSFSSSEEKCWRLHDYLVGTLGPYVINVTKAAMACSHQRCHGHGRCARKDPGQMEAFLHLQPDDSLGAWNSFRCHCYSGWAGPTCLEPKP
uniprot
proteins
ec_number
3.2.1.35
uniprot
proteins
function
FUNCTION: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm (PubMed:20586096). Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage (PubMed:18653706). Has no hyaluronidase activity in embryonic fibroblasts in vitro (PubMed:18234732). Has no hyaluronidase activity in granulosa cells in vitro (PubMed:18653706). {ECO:0000269|PubMed:18234732, ECO:0000269|PubMed:18653706, ECO:0000269|PubMed:20586096}.
uniprot
proteins
mass_dalton
46132
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:18234732}.
uniprot
proteins
protein_family
Glycosyl hydrolase 56 family
uniprot
proteins
pubmed
11929860
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18234732
uniprot
proteins
pubmed
18653706
uniprot
proteins
pubmed
18762256
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20586096
uniprot
proteins
sequence_length
412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20586096}. Cell membrane {ECO:0000269|PubMed:20586096}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:20586096}. Endoplasmic reticulum {ECO:0000269|PubMed:18234732}. Early endosome {ECO:0000269|PubMed:18234732}. Note=Mostly present in low-density vesicles. Low levels in higher density vesicles of late endosomes and lysosomes. Localized in punctate cytoplasmic vesicles and in perinuclear structures, but does not colocalize with LAMP1 (PubMed:18234732). Localized on the plasma membrane over the acrosome and on the surface of the midpiece of the sperm tail (PubMed:20586096). {ECO:0000269|PubMed:18234732, ECO:0000269|PubMed:20586096}.
uniprot
proteins