Tfcp2l1
entrez
81879
canonical
uniprot
Q3UNW5
canonical
ensembl
ENSMUSG00000026380
resolver
ensp
ENSMUSP00000027629
resolver
ensp
ENSMUSP00000255004
resolver
enst
ENSMUST00000027629
resolver
genesymbol
Tfcp2l1
resolver
genesymbol_syn
Crtr1
resolver
genesymbol_syn
Tcfcp2l1
resolver
uniprot
Q14AW3
resolver
uniprot
Q99PF2
resolver
uniprot_entry
TF2L1_MOUSE
resolver
uniprot_sec
Q14AW3
resolver
uniprot_sec
Q99PF2
resolver
amino_acid_sequence
MLFWHTQPEHYNQHNSGSYLRDVLALPIFKQEEPQLSPENGARLPPLQYVLCAATSPAVKLHEETLTYLNQGQSYEIRLLENRKLGDFQDLNTKYVKSIIRVVFHDRRLQYTEYQQLEGWRWSRPGDRILDIDIPLSVGILDPRASPTQLNAVEFLWDPSKRASAFIQVHCISTEFTPRKHGGEKGVPFRVQIDTFKQNESGDYSEHLHSASCQIKVFKPKGADRKQKTDREKMEKRTAQEKEKYQPSYETTILTECSPWPDVPYQANNTPSPSYNGSPNSFGLREGNSSPNHPVEPLPLGSDHLLPSASIQDAQQWLHRNRFSQFCWLFASFSGADLLKMSRDDLVQVCGPADGIRLFNAIKGRNVRPKMTIYVCQELEQNQLPLPQKQDDSGDNSLCVYHAIFLEELTTLELTEKIASLYSIPPQHIHRVYRQGPAGIHVVVSNEMVQNFQDESCFILSTLKAESNDGYHIILKCGL
uniprot
proteins
function
FUNCTION: Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:23942233, PubMed:26321140). With Klf2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/Stat3 and Wnt/beta-catenin signaling (PubMed:23942233, PubMed:23942238, PubMed:26321140). Required for normal duct development in the salivary gland and kidney (PubMed:17079272). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (PubMed:28577314). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, Oxgr1, Ca12, Slc4a1, Aqp6 and IC-specific transcription factor Foxi1 (PubMed:28577314). Also regulates the expression of Jag1 and subsequent notch signaling in the collecting duct (PubMed:28577314). Jag1 initiates notch signaling in PCs but inhibits notch signaling in ICs (PubMed:28577314). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (PubMed:11073954). Modulates the placental expression of CYP11A1 (By similarity). {ECO:0000250|UniProtKB:Q9NZI6, ECO:0000269|PubMed:11073954, ECO:0000269|PubMed:17079272, ECO:0000269|PubMed:23942233, ECO:0000269|PubMed:23942238, ECO:0000269|PubMed:26321140, ECO:0000269|PubMed:28577314}.
uniprot
proteins
mass_dalton
54737
uniprot
proteins
protein_family
CP2 subfamily
uniprot
proteins
protein_family
Grh/CP2 family
uniprot
proteins
pubmed
11073954
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17079272
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23942233
uniprot
proteins
pubmed
23942238
uniprot
proteins
pubmed
26321140
uniprot
proteins
pubmed
28577314
uniprot
proteins
pubmed
28982712
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28577314}.
uniprot
proteins