NEIL1
entrez
79661
canonical
uniprot
Q96FI4
canonical
ensembl
ENSG00000140398
resolver
ensp
ENSP00000347170
resolver
ensp
ENSP00000455730
resolver
ensp
ENSP00000457352
resolver
ensp
ENSP00000536972
resolver
ensp
ENSP00000536973
resolver
ensp
ENSP00000536978
resolver
ensp
ENSP00000536979
resolver
ensp
ENSP00000536980
resolver
ensp
ENSP00000536981
resolver
ensp
ENSP00000536984
resolver
ensp
ENSP00000536986
resolver
enst
ENST00000355059
resolver
enst
ENST00000564784
resolver
enst
ENST00000569035
resolver
enst
ENST00000866913
resolver
enst
ENST00000866914
resolver
enst
ENST00000866919
resolver
enst
ENST00000866920
resolver
enst
ENST00000866921
resolver
enst
ENST00000866922
resolver
enst
ENST00000866925
resolver
enst
ENST00000866927
resolver
genesymbol
NEIL1
resolver
hgnc
HGNC:18448
resolver
uniprot
D3DW75
resolver
uniprot
Q6ZRA7
resolver
uniprot
Q86XW7
resolver
uniprot
Q9H6C3
resolver
uniprot_entry
NEIL1_HUMAN
resolver
uniprot_sec
D3DW75
resolver
uniprot_sec
Q6ZRA7
resolver
uniprot_sec
Q86XW7
resolver
uniprot_sec
Q9H6C3
resolver
amino_acid_sequence
MPEGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASARGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRFYTAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRNLADKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEALQQHRPSPELTLSQKIRTKLQNPDLLELCHSVPKEVVQLGGKGYGSESGEEDFAAFRAWLRCYGMPGMSSLQDRHGRTIWFQGDPGPLAPKGRKSRKKKSKATQLSPEDRVEDALPPSKAPSRTRRAKRDLPKRTATQRPEGTSLQQDPEAPTVPKKGRRKGRQAASGHCRPRKVKADIPSLEPEGTSAS
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
ec_number
4.2.99.18
uniprot
proteins
function
FUNCTION: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000269|PubMed:11904416, ECO:0000269|PubMed:12200441, ECO:0000269|PubMed:12509226, ECO:0000269|PubMed:14522990}.
uniprot
proteins
mass_dalton
43684
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="P->T: Loss of glycosylase and AP lyase activity."; /evidence="ECO:0000269|PubMed:11904416, ECO:0000269|PubMed:12509226"; MUTAGEN 2; /note="Missing: Loss of glycosylase activity."; /evidence="ECO:0000269|PubMed:11904416, ECO:0000269|PubMed:12509226"; MUTAGEN 3; /note="E->Q: Loss of glycosylase and AP lyase activity."; /evidence="ECO:0000269|PubMed:12509226"; MUTAGEN 54; /note="K->L: Loss of glycosylase activity."; /evidence="ECO:0000269|PubMed:14522990"; MUTAGEN 277; /note="R->A: Strongly reduced glycosylase activity. Has little effect on AP lyase activity."; /evidence="ECO:0000269|PubMed:15232006
uniprot
proteins
protein_family
FPG family
uniprot
proteins
pubmed
11904416
uniprot
proteins
pubmed
12200441
uniprot
proteins
pubmed
12509226
uniprot
proteins
pubmed
14522990
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15232006
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17556049
uniprot
proteins
pubmed
21068368
uniprot
proteins
pubmed
21697813
uniprot
proteins
pubmed
23595123
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17556049}. Nucleus {ECO:0000269|PubMed:17556049}. Chromosome {ECO:0000269|PubMed:17556049}. Note=During mitosis, associates with centrosomes and condensed chromatin.
uniprot
proteins