E0CYC6
uniprot
E0CYC6
canonical
amino_acid_sequence
MPRFEAQKSSMVPYHIRQYQDSDHKRVVDVFTTGAEEYIPSTFRHVLRLPRTFLLLLGVPLALVLVSGSWILAVICIFFLLLLLRLLARQPWKEYVAKCLQTYMVDITKSYLNVHGACFWVAESGGQVVGIVAAQPVKDPPLGRKQLQLFRLSVSSQHRGQGIAKALTRTVLQFARDQSYSDVVLETSTLQQGAMTLYLGMGFKKTGQYFKSMFWRLVDICFIQLNYSFPSA
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER)-membrane-bound lysine N-acetyltransferase catalyzing the N6-acetylation of lysine residues in the lumen of the ER in various proteins, including PROM1 and BACE1, using acetyl-CoA as acetyl donor. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. Acetylates and stabilizes BACE1 immature protein, leading to increased steady-state levels in neurons. By acting on BACE1 expression, may regulate amyloid beta-peptide formation (By similarity). N(6)-lysine acetylation in ER maintains protein homeostasis and regulates reticulophagy (PubMed:33846551). {ECO:0000250|UniProtKB:Q9UHF3, ECO:0000269|PubMed:33846551}.
uniprot
proteins
mass_dalton
26389
uniprot
proteins
post_translational_modification
PTM: Acetylation on Lys-109 modulates enzymatic activity. {ECO:0000250|UniProtKB:Q9UHF3}.
uniprot
proteins
protein_family
NAT8 family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22267734
uniprot
proteins
pubmed
33846551
uniprot
proteins
sequence_length
232
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q9UHF3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9UHF3}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UHF3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9UHF3}. Note=Enriched in the endoplasmic reticulum-Golgi intermediate compartment. {ECO:0000250|UniProtKB:Q9UHF3}.
uniprot
proteins
transmembrane_region
TRANSMEM 63..83; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins