METTL9
entrez
51108
canonical
uniprot
Q9H1A3
canonical
ensembl
ENSG00000197006
resolver
ensp
ENSP00000350874
resolver
ensp
ENSP00000379335
resolver
ensp
ENSP00000454733
resolver
genesymbol
METTL9
resolver
genesymbol_syn
DREV
resolver
hgnc
HGNC:24586
resolver
uniprot
Q8NBT8
resolver
uniprot
Q9BWJ7
resolver
uniprot
Q9H1A2
resolver
uniprot
Q9Y390
resolver
uniprot_entry
METL9_HUMAN
resolver
uniprot_sec
Q8NBT8
resolver
uniprot_sec
Q9BWJ7
resolver
uniprot_sec
Q9H1A2
resolver
uniprot_sec
Q9Y390
resolver
amino_acid_sequence
MRLLAGWLCLSLASVWLARRMWTLRSPLTRSLYVNMTSGPGGPAAAAGGRKENHQWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPDQFQRLLKINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIRSVLEPTRGRVILALVLPFHPYVENVGGKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAFTRLPYLCEGDMYNDYYVLDDAVFVLKPV
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins (PubMed:33563959, PubMed:34562450, PubMed:37015930, PubMed:37398635). Specifically methylates the second His of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid), while exploiting the first one as a recognition signature (PubMed:37398635). Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins (PubMed:33563959, PubMed:34562450, PubMed:37015930, PubMed:37398635). Constitutes the main methyltransferase for the 1-methylhistidine modification in cell (PubMed:33563959). {ECO:0000269|PubMed:33563959, ECO:0000269|PubMed:34562450, ECO:0000269|PubMed:37015930, ECO:0000269|PubMed:37398635}.
uniprot
proteins
mass_dalton
36536
uniprot
proteins
mutagenesis
MUTAGEN 115; /note="T->A: Decreased binding to S-adenosyl-L-homocysteine and substrate proteins."; /evidence="ECO:0000269|PubMed:37398635"; MUTAGEN 118; /note="N->A: Decreased binding to S-adenosyl-L-homocysteine and substrate proteins."; /evidence="ECO:0000269|PubMed:37398635"; MUTAGEN 123; /note="R->A: Abolished binding to substrate proteins."; /evidence="ECO:0000269|PubMed:37398635"; MUTAGEN 126; /note="M->A: Nearly abolished binding to substrate proteins."; /evidence="ECO:0000269|PubMed:37398635"; MUTAGEN 151; /note="D->A: Abolished binding to S-adenosyl-L-homocysteine."; /evidence="ECO:0000269|PubMed:37398635"; MUTAGEN 156; /note="D->A: Abolished binding to S-adenosyl-L-homocysteine."; /evidence="ECO:0000269|PubMed:37398635"; MUTAGEN 173; /note="T->A: Decreased binding to S-adenosyl-L-homocysteine."; /evidence="ECO:0000269|PubMed:37398635"; MUTAGEN 174; /note="E->A: Abolished protein-L-histidine N-pros-methyltransferase activity."; /evidence="ECO:0000269|PubMed:33563959, ECO:0000269|PubMed:37015930"; MUTAGEN 210; /note="N->D: Abolished binding to S-adenosyl-L-homocysteine."; /evidence="ECO:0000269|PubMed:37398635"; MUTAGEN 213; /note="D->A: Abolished binding to substrate proteins."; /evidence="ECO:0000269|PubMed:37015930, ECO:0000269|PubMed:37398635"; MUTAGEN 214; /note="R->A: Decreased binding to SLC39A5 substrate."; /evidence="ECO:0000269|PubMed:37015930"; MUTAGEN 214; /note="R->D: Abolished binding to S-adenosyl-L-homocysteine and substrate proteins."; /evidence="ECO:0000269|PubMed:37398635"; MUTAGEN 241; /note="V->G: Reduced binding to substrate proteins."; /evidence="ECO:0000269|PubMed:37398635"; MUTAGEN 249; /note="E->A: Abolished binding to substrate proteins."; /evidence="ECO:0000269|PubMed:37398635"; MUTAGEN 295; /note="Y->A: Abolished binding to S-adenosyl-L-homocysteine."; /evidence="ECO:0000269|PubMed:37398635"; MUTAGEN 297; /note="C->A: Reduced binding to substrate proteins."; /evidence="ECO:0000269|PubMed:37398635"; MUTAGEN 300; /note="D->A: Abolished binding to substrate proteins."; /evidence="ECO:0000269|PubMed:37015930, ECO:0000269|PubMed:37398635"; MUTAGEN 306..308; /note="YVL->AVA: Abolished protein-L-histidine N-pros-methyltransferase activity."; /evidence="ECO:0000269|PubMed:37015930
uniprot
proteins
protein_family
METTL9 family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11132146
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
33563959
uniprot
proteins
pubmed
34562450
uniprot
proteins
pubmed
37015930
uniprot
proteins
pubmed
37398635
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:34562450, ECO:0000305|PubMed:33563959}. Mitochondrion {ECO:0000305|PubMed:33563959}. Note=Colocalizes with membranous compartments such as the endoplasmic reticulum and mitochondria. {ECO:0000269|PubMed:33563959}.
uniprot
proteins