Hnrnpa2b1
entrez
362361
canonical
uniprot
A7VJC2
canonical
ensembl
ENSRNOG00000011175
resolver
ensp
ENSRNOP00000015152
resolver
ensp
ENSRNOP00000077328
resolver
enst
ENSRNOT00000015152
resolver
enst
ENSRNOT00000116353
resolver
genesymbol
Hnrnpa2b1
resolver
genesymbol_syn
Hnrnp
resolver
genesymbol_syn
Hnrpa2b1
resolver
uniprot
A0A8I5Y7N4
resolver
uniprot
A7VJC1
resolver
uniprot
A7VJC3
resolver
uniprot
A7VJC4
resolver
uniprot
F1LNF1
resolver
uniprot_entry
A0A8I5Y7N4_RAT
resolver
uniprot_entry
F1LNF1_RAT
resolver
uniprot_entry
ROA2_RAT
resolver
uniprot_sec
A7VJC1
resolver
uniprot_sec
A7VJC3
resolver
uniprot_sec
A7VJC4
resolver
amino_acid_sequence
MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIFLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGNYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRSRY
uniprot
proteins
function
FUNCTION: Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus (PubMed:19099192). Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417, PubMed:9578590). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (PubMed:15659580). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity). Also plays a role in the activation of the innate immune response. Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6. In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (By similarity). {ECO:0000250|UniProtKB:P22626, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:15659580, ECO:0000269|PubMed:9578590, ECO:0000303|PubMed:19099192}.
uniprot
proteins
mass_dalton
37478
uniprot
proteins
mutagenesis
MUTAGEN 266; /note="R->A: Decreased methylation. Does not affect subcellular location."; /evidence="ECO:0000269|PubMed:24098712
uniprot
proteins
post_translational_modification
PTM: Asymmetric dimethylation at Arg-266 constitutes the major methylation site (PubMed:24098712). According to a report, methylation affects subcellular location and promotes nuclear localization (PubMed:10772824). According to another report, methylation at Arg-266 does not influence nucleocytoplasmic shuttling (PubMed:24098712). {ECO:0000269|PubMed:10772824, ECO:0000269|PubMed:24098712}.; PTM: Sumoylated in exosomes, promoting miRNAs-binding. {ECO:0000250|UniProtKB:P22626}.
uniprot
proteins
pubmed
10567417
uniprot
proteins
pubmed
10772824
uniprot
proteins
pubmed
15659580
uniprot
proteins
pubmed
19099192
uniprot
proteins
pubmed
19343716
uniprot
proteins
pubmed
20406423
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24098712
uniprot
proteins
pubmed
9578590
uniprot
proteins
pubmed
9925756
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform B1]: Nucleus {ECO:0000269|PubMed:20406423}.; SUBCELLULAR LOCATION: [Isoform A2]: Nucleus {ECO:0000269|PubMed:20406423, ECO:0000269|PubMed:24098712}.; SUBCELLULAR LOCATION: [Isoform A2b]: Cytoplasm {ECO:0000269|PubMed:20406423}. Nucleus {ECO:0000269|PubMed:20406423}. Note=Mainly localizes in the cytoplasm in neural cells. {ECO:0000269|PubMed:20406423}.; SUBCELLULAR LOCATION: [Isoform B1b]: Cytoplasm {ECO:0000269|PubMed:20406423}. Nucleus {ECO:0000269|PubMed:20406423}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P22626}. Nucleus, nucleoplasm {ECO:0000269|PubMed:9578590, ECO:0000269|PubMed:9925756}. Cytoplasm {ECO:0000269|PubMed:9925756}. Cytoplasmic granule {ECO:0000250|UniProtKB:P22626}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P22626}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Not found in the nucleolus. Found in exosomes following sumoylation. {ECO:0000250|UniProtKB:P22626}.
uniprot
proteins