Cavin2
entrez
316384
canonical
uniprot
Q66H98
canonical
ensembl
ENSRNOG00000025895
resolver
ensp
ENSRNOP00000030025
resolver
enst
ENSRNOT00000028907
resolver
genesymbol
Cavin2
resolver
genesymbol_syn
Sdpr
resolver
uniprot_entry
CAVN2_RAT
resolver
amino_acid_sequence
MGEDAAQAEKFQHPNTDMLQEKPSNPSPMPSSTPSPSLNLGSTEEAIRDNSQVNAVTVHTLLDKLVNMLDAVRENQHNMEQRQINLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVRERLEKQCVQVKRLENNHAQLLRRNHFKVLIFQEESEIPASVFVKEPVPSTAEGKELADENKSLEETLHNVDLSSDDELPGDEEALEDSAEEKMEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTPNHQKASSGKSSPFKVSPLSFGRKKIREGESSAENETKLEEQVQDDHEEGSFTEGLSEASLPSGLLEGSAEDAEKSALRGNNSGVGSNADLTIEEDEEEESVALQQAQQVRYESGYMLNSKEMEESSEKHVQAAVLHVDQTA
uniprot
proteins
function
FUNCTION: Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells (By similarity). May play a role in targeting PRKCA to caveolae (PubMed:9566962). {ECO:0000250|UniProtKB:O95810, ECO:0000250|UniProtKB:Q63918, ECO:0000269|PubMed:9566962}.
uniprot
proteins
mass_dalton
46386
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked. {ECO:0000250}.; PTM: Phosphorylated on Ser residues. {ECO:0000250}.
uniprot
proteins
protein_family
CAVIN family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9566962
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O95810}. Membrane, caveola {ECO:0000269|PubMed:9566962}. Note=Localizes in the caveolae in a caveolin-dependent manner. {ECO:0000269|PubMed:9566962}.
uniprot
proteins