Lsm14b
entrez
241846
canonical
uniprot
Q8CGC4
canonical
ensembl
ENSMUSG00000039108
resolver
ensp
ENSMUSP00000055036
resolver
ensp
ENSMUSP00000062519
resolver
ensp
ENSMUSP00000226234
resolver
ensp
ENSMUSP00000347576
resolver
ensp
ENSMUSP00000347578
resolver
ensp
ENSMUSP00000347580
resolver
ensp
ENSMUSP00000347582
resolver
ensp
ENSMUSP00000347583
resolver
enst
ENSMUST00000055485
resolver
genesymbol
Lsm14b
resolver
genesymbol_syn
BC040823
resolver
genesymbol_syn
Fam61b
resolver
genesymbol_syn
Rap55b
resolver
uniprot
A2AC71
resolver
uniprot
Q4KL69
resolver
uniprot_entry
LS14B_MOUSE
resolver
uniprot_entry
Q4KL69_MOUSE
resolver
uniprot_sec
A2AC71
resolver
amino_acid_sequence
MSGSSGTPYLGSKISLISKAQIRYEGILYTIDTDNSTVALAKVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMPPYGQLAASSLLSQQYAASLGLGAGFPSTPVGKSPMVEQAVQTSSVDNLNAKKLLPSKVTSATQLNGRQAQPSSKPASDVVQPAPVHTQGQVNDENRRPPRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKADKGEEKDPAVMAQSEETAAEEDLLGPNCYYDKSKSFFDNISSELKTSSRRTTWAEERKLNTETFGVSGRFLRGRSSRGGFRGGRGNGTTRRNPTSHRAGTGRV
uniprot
proteins
function
FUNCTION: mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes (PubMed:28458300, PubMed:37083226, PubMed:37481122, PubMed:37578641, PubMed:37889087). Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes (PubMed:37083226, PubMed:37481122, PubMed:37578641, PubMed:37889087). Promotes the translation of some oogenesis-related mRNAs (PubMed:37083226, PubMed:37578641). Regulates the expression and/or localization of some key P-body proteins in oocytes (PubMed:37481122). Essential for the assembly of the primordial follicle in the ovary (PubMed:37578641). {ECO:0000250|UniProtKB:Q68FI1, ECO:0000269|PubMed:28458300, ECO:0000269|PubMed:37083226, ECO:0000269|PubMed:37481122, ECO:0000269|PubMed:37578641, ECO:0000269|PubMed:37889087}.
uniprot
proteins
mass_dalton
42310
uniprot
proteins
protein_family
LSM14 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18723115
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
28458300
uniprot
proteins
pubmed
37083226
uniprot
proteins
pubmed
37481122
uniprot
proteins
pubmed
37578641
uniprot
proteins
pubmed
37889087
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:37083226, ECO:0000269|PubMed:37578641, ECO:0000269|PubMed:37889087}. Note=Localizes to MARDO (mitochondria-associated ribonucleoprotein domain), a mitochondria-associated membraneless compartment that stores mRNAs in oocytes. {ECO:0000269|PubMed:37578641, ECO:0000269|PubMed:37889087}.
uniprot
proteins