Abcc3
entrez
76408
canonical
uniprot
B2RX12
canonical
ensembl
ENSMUSG00000020865
resolver
ensp
ENSMUSP00000021231
resolver
ensp
ENSMUSP00000136343
resolver
enst
ENSMUST00000021231
resolver
genesymbol
Abcc3
resolver
genesymbol_syn
Cmoat2
resolver
genesymbol_syn
Mrp3
resolver
uniprot
A0A0R4J015
resolver
uniprot
J3QML2
resolver
uniprot
Q3U1W8
resolver
uniprot
Q56PH0
resolver
uniprot
Q59DK9
resolver
uniprot
Q59DL0
resolver
uniprot
Q5SUF4
resolver
uniprot
Q80ZK8
resolver
uniprot_entry
A0A0R4J015_MOUSE
resolver
uniprot_entry
MRP3_MOUSE
resolver
uniprot_sec
J3QML2
resolver
uniprot_sec
Q3U1W8
resolver
uniprot_sec
Q56PH0
resolver
uniprot_sec
Q59DK9
resolver
uniprot_sec
Q59DL0
resolver
uniprot_sec
Q5SUF4
resolver
uniprot_sec
Q80ZK8
resolver
amino_acid_sequence
MDRLCGSGELGSKFWDSNLSIYTNTPDLTPCFQNSLLAWVPCIYLWAALPCYLFYLRHHQLGYIVLSWLSRLKTALGVLLWCVSWVDLFYSFHGLIHGSSPAPVFFVTPLVVGITMLLATLLIQYERLRGVQSSGVLIIFWLLCVICAIIPFRSKILSALAEGKILDPFRFTTFYIYFALVFCALILSCFKEKPPLFSPENLDTNPCPEASAGFFSRLSFWWFTRLAILGYRRPLEDRDLWSLSEEDCSHKVVQRLLEAWQKQQNQASRSQTATAEPKIPGEDAVLLKPRPKSKQPSFLRALVRTFTSSLLMSACFNLIQNLLGFVNPQLLSILIRFISDPTAPTWWGFLLAGLMFLSSTMQTLILHQYYHCIFVMALRLRTAIIGVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKGIRQSELQLLRKGAYLQAISTFIWICTPFLVTLITLGVYVYVDESNVLDAEKAFVSLSLFNILKIPLNMLPQLISGLTQASVSLKRIQDFLNQNELDPQCVERKTISPGYAITIHNGTFTWAQDLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLAGGQVSEMGHYSALLQHDGSFANFLRNYAPDEDQEDHEAALQNANEEVLLLEDTLSTHTDLTDNEPAIYEVRKQFMREMSSLSSEGEVQNRTMPKKHTNSLEKEALVTKTKETGALIKEEIAETGNVKLSVYWDYAKSMGLCTTLSICLLYGGQSAAAIGANVWLSAWSNDAEEHGQQNKTSVRLGVYAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRILNRFSKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYVATSRQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYIASNRWLGVHVEFVGNCVVLFAALFAVIGRNSLNPGLVGLSVSYALQVTMALNWMIRMISDLESNIIAVERVKEYSKTKTEAPWVVESNRAPEGWPTRGMVEFRNYSVRYRPGLELVLKNVTVHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIAAGGIFYGMAKDAGLA
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
ec_number
7.6.2.3
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at basolateral membranes of polarized cells such as hepatocytes and intestinal epithelial cells, where it mediates the efflux of conjugated substrates from intestine and liver into the bloodstream (By similarity). Involved in enterohepatic recirculation of steroid glucuronates. Shares substrate specificity with MRP2, displaying higher affinity for both estrogen and androgen glucuronates such as 17beta-estradiol, estrone, testosterone and 5alpha-dihydrotestosterone glucuronates (By similarity). Involved in sinusoidal efflux of mono- and bis-glucuronidated bilirubin from hepatocytes into the blood for renal uptake and excretion (By similarity). May selectively transport steroid sulfate conjugates. Has transporter activity toward androgen sulfates such as androsterone and dehydroepiandrosterone sulfates but is inactive toward estrone 3-sulfate (By similarity). Can transport various bile acid conjugates such as taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate and taurolithocholate-3-sulfate. Does not contribute substantially to bile acids physiology, but provides an alternative route for the export of bile acids and glucuronate conjugates from cholestatic hepatocytes to avoid liver damage (By similarity) (PubMed:15814571, PubMed:16225954). Can also transport glutathione conjugates such as leukotriene C4 (LTC4) (By similarity). Transports various xenobiotics. Confers resistance to anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells. May contribute to the transport of organic compounds in testes across the blood-testis-barrier (By similarity). {ECO:0000250|UniProtKB:O15438, ECO:0000250|UniProtKB:O88563, ECO:0000269|PubMed:15814571, ECO:0000269|PubMed:16225954}.
uniprot
proteins
mass_dalton
169223
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCC family
uniprot
proteins
protein_family
Conjugate transporter (TC 3.A.1.208) subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15814571
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16225954
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:16225954}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Basal cell membrane {ECO:0000250|UniProtKB:O15438}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..54; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 73..89; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 107..122; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 134..148; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 172..189; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 315..330; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 352..366; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 430..443; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 449..464; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 531..548; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 568..583; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 964..984; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1012..1028; /note="Helical; Name=13"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1084..1100; /note="Helical; Name=14"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1107..1119; /note="Helical; Name=15"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1192..1207; /note="Helical; Name=16"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1224..1239; /note="Helical; Name=17"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins