CNOT3
entrez
4849
canonical
uniprot
O75175
canonical
ensembl
ENSG00000088038
resolver
ensembl
ENSG00000273943
resolver
ensembl
ENSG00000274176
resolver
ensembl
ENSG00000274616
resolver
ensembl
ENSG00000274941
resolver
ensembl
ENSG00000275979
resolver
ensembl
ENSG00000276082
resolver
ensembl
ENSG00000277114
resolver
ensembl
ENSG00000277600
resolver
ensembl
ENSG00000277615
resolver
ensp
ENSP00000221232
resolver
ensp
ENSP00000351159
resolver
ensp
ENSP00000478280
resolver
ensp
ENSP00000478956
resolver
ensp
ENSP00000479987
resolver
ensp
ENSP00000480258
resolver
ensp
ENSP00000480585
resolver
ensp
ENSP00000480697
resolver
ensp
ENSP00000480876
resolver
ensp
ENSP00000480988
resolver
ensp
ENSP00000481681
resolver
ensp
ENSP00000481924
resolver
ensp
ENSP00000483036
resolver
ensp
ENSP00000483431
resolver
ensp
ENSP00000483604
resolver
ensp
ENSP00000483692
resolver
ensp
ENSP00000483882
resolver
ensp
ENSP00000483968
resolver
ensp
ENSP00000484040
resolver
ensp
ENSP00000484794
resolver
ensp
ENSP00000496602
resolver
ensp
ENSP00000566623
resolver
ensp
ENSP00000566624
resolver
ensp
ENSP00000603560
resolver
ensp
ENSP00000603561
resolver
ensp
ENSP00000603562
resolver
ensp
ENSP00000603563
resolver
ensp
ENSP00000603565
resolver
ensp
ENSP00000603566
resolver
ensp
ENSP00000603568
resolver
ensp
ENSP00000603571
resolver
ensp
ENSP00000665870
resolver
ensp
ENSP00000665871
resolver
ensp
ENSP00000754571
resolver
enst
ENST00000221232
resolver
enst
ENST00000358389
resolver
enst
ENST00000610883
resolver
enst
ENST00000611252
resolver
enst
ENST00000612924
resolver
enst
ENST00000613528
resolver
enst
ENST00000613752
resolver
enst
ENST00000614649
resolver
enst
ENST00000615030
resolver
enst
ENST00000616359
resolver
enst
ENST00000616910
resolver
enst
ENST00000617930
resolver
enst
ENST00000617982
resolver
enst
ENST00000618405
resolver
enst
ENST00000619567
resolver
enst
ENST00000619854
resolver
enst
ENST00000620060
resolver
enst
ENST00000620419
resolver
enst
ENST00000620573
resolver
enst
ENST00000620970
resolver
enst
ENST00000622131
resolver
enst
ENST00000896565
resolver
enst
ENST00000933502
resolver
enst
ENST00000933503
resolver
enst
ENST00000933504
resolver
enst
ENST00000933507
resolver
enst
ENST00000933509
resolver
enst
ENST00000933512
resolver
genesymbol
CNOT3
resolver
genesymbol_syn
KIAA0691
resolver
genesymbol_syn
LENG2
resolver
genesymbol_syn
NOT3
resolver
hgnc
HGNC:7879
resolver
uniprot
B7Z6J7
resolver
uniprot
Q9NZN7
resolver
uniprot
Q9UF76
resolver
uniprot_entry
B7Z6J7_HUMAN
resolver
uniprot_entry
CNOT3_HUMAN
resolver
uniprot_sec
Q9NZN7
resolver
uniprot_sec
Q9UF76
resolver
amino_acid_sequence
MADKRKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAANANQKEKYEADLKKEIKKLQRLRDQIKTWVASNEIKDKRQLIDNRKLIETQMERFKVVERETKTKAYSKEGLGLAQKVDPAQKEKEEVGQWLTNTIDTLNMQVDQFESEVESLSVQTRKKKGDKDKQDRIEGLKRHIEKHRYHVRMLETILRMLDNDSILVDAIRKIKDDVEYYVDSSQDPDFEENEFLYDDLDLEDIPQALVATSPPSHSHMEDEIFNQSSSTPTSTTSSSPIPPSPANCTTENSEDDKKRGRSTDSEVSQSPAKNGSKPVHSNQHPQSPAVPPTYPSGPPPAASALSTTPGNNGVPAPAAPPSALGPKASPAPSHNSGTPAPYAQAVAPPAPSGPSTTQPRPPSVQPSGGGGGGSGGGGSSSSSNSSAGGGAGKQNGATSYSSVVADSPAEVALSSSGGNNASSQALGPPSGPHNPPPSTSKEPSAAAPTGAGGVAPGSGNNSGGPSLLVPLPVNPPSSPTPSFSDAKAAGALLNGPPQFSTAPEIKAPEPLSSLKSMAERAAISSGIEDPVPTLHLTERDIILSSTSAPPASAQPPLQLSEVNIPLSLGVCPLGPVPLTKEQLYQQAMEEAAWHHMPHPSDSERIRQYLPRNPCPTPPYHHQMPPPHSDTVEFYQRLSTETLFFIFYYLEGTKAQYLAAKALKKQSWRFHTKYMMWFQRHEEPKTITDEFEQGTYIYFDYEKWGQRKKEGFTFEYRYLEDRDLQ
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder with speech delay, autism and dysmorphic facies (IDDSADF) [MIM:618672]: An autosomal dominant disorder characterized by mild to severe intellectual disability, developmental delay, delayed or absent speech, hypotonia, short stature, autistic features, and highly variable dysmorphic facial features. {ECO:0000269|PubMed:31201375}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:22342980, ECO:0000269|PubMed:22367759}.
uniprot
proteins
mass_dalton
81872
uniprot
proteins
protein_family
CNOT2/3/5 family
uniprot
proteins
pubmed
10637334
uniprot
proteins
pubmed
12207886
uniprot
proteins
pubmed
14707134
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19558367
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21299754
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22342980
uniprot
proteins
pubmed
22367759
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27807034
uniprot
proteins
pubmed
31201375
uniprot
proteins
pubmed
31570513
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
753
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Cytoplasm, P-body {ECO:0000250}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.
uniprot
proteins