Drc7
entrez
330830
canonical
uniprot
Q6V3W6
canonical
ensembl
ENSMUSG00000031786
resolver
ensp
ENSMUSP00000053972
resolver
ensp
ENSMUSP00000276514
resolver
genesymbol
Drc7
resolver
genesymbol_syn
Ccdc135
resolver
genesymbol_syn
Gm770
resolver
genesymbol_syn
Srgl
resolver
uniprot
G3X9B0
resolver
uniprot
Q148T2
resolver
uniprot_entry
DRC7_MOUSE
resolver
uniprot_sec
G3X9B0
resolver
uniprot_sec
Q148T2
resolver
amino_acid_sequence
MEVLREKVEEEEEAEREEAAERAERTEKLERVTKSAEVSREGTILSQDELRDLEGKLMAIEIPTQADHSVISQAPVDVTKLPPSYTTNSLKEEHLLLVADNFSRQYSHLCPDRVPLFLHPLNECNVPKFVSTTLRPTLMPYPELYNWDSCAQFVSDFLTMVPLVDPLKPPTHLYSSTTVLKCQKGNCFDFSTLLCSMLIGSGYDAYCVNGYGSLDLCLMDLTREVCPLTVKAKEIVKKKEKTVPKKYSIKPPRDLTSKFEQEQEEKRIQEIKDLEQRRLKEEEDRILEAEKAKPDPLHGLRVHSWVLVLAGKREVPESFFIDPLTARSYSTKDEHFLGIESLWNHKNYWINMQDCWNCCKDLIFDLGDPVRWEYMLLGTDKPHLSLTEEDEEGLDDDDDDVEDLGKEEEDKSFDMPSSWVSQIEITPEEFETRCPSGKKVIQYKKAQLEKWSPYLNNNGLVCRLTTYEDQQCTKVLEIKEWYQNREDMLELKHINKTTGLHVDYFKPGHPQALCVHSYKSMLPEMDRVMEFYKKIRVDGLVKREETPMTMTEYYEGRSDFLAYRHVNFGPRVKKLSQSSVESNPRPMVKITERFSRNPEKPADEDVAERLFLIVEERIQLRYHCRDDYITASKREFLRRMEVDSKGNKIIMTPEMCISYEVEPMEHTKKLLYQYETMNQLKNEEKLSRHQAWESELEVLEILKLREEEEEAHTLTISIYDTKRNEKSKEYREAMERVLHEEHLRQVEAQLDYLAPFLAQLPPGEKLTRWQAVRLKDECLSDFKQRLIDKANLIQARFEKETQELQKKQQWYQENQVTLTPEDENLYLSYCSQAMFRIRILEQRLNRHKELAPLKYLALEEKLYKDPRLIDFVKVFV
uniprot
proteins
function
FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Essential for male fertility, sperm head morphogenesis and sperm flagellum formation (PubMed:31961863). Not required for ciliogenesis in the brain and trachea (PubMed:31961863). {ECO:0000250|UniProtKB:A8JAM0, ECO:0000269|PubMed:31961863}.
uniprot
proteins
mass_dalton
103269
uniprot
proteins
protein_family
DRC7 family
uniprot
proteins
pubmed
15156272
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16804880
uniprot
proteins
pubmed
17971504
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28630322
uniprot
proteins
pubmed
31961863
uniprot
proteins
sequence_length
876
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:A8JAM0}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A8JAM0}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8JAM0}. Note=Associated with the outer doublet microtubules (OD). {ECO:0000250|UniProtKB:A8JAM0}.
uniprot
proteins