KREMEN2
entrez
79412
canonical
uniprot
Q8NCW0
canonical
ensembl
ENSG00000131650
resolver
ensp
ENSP00000304422
resolver
ensp
ENSP00000322079
resolver
ensp
ENSP00000459878
resolver
ensp
ENSP00000461860
resolver
genesymbol
KREMEN2
resolver
genesymbol_syn
KRM2
resolver
hgnc
HGNC:18797
resolver
uniprot
B4DXF6
resolver
uniprot
I3L2S2
resolver
uniprot
Q53F67
resolver
uniprot
Q8N2J4
resolver
uniprot
Q8NCW1
resolver
uniprot
Q96GL8
resolver
uniprot
Q9BTP9
resolver
uniprot_entry
KREM2_HUMAN
resolver
uniprot_entry
Q53F67_HUMAN
resolver
uniprot_sec
B4DXF6
resolver
uniprot_sec
I3L2S2
resolver
uniprot_sec
Q8N2J4
resolver
uniprot_sec
Q8NCW1
resolver
uniprot_sec
Q96GL8
resolver
uniprot_sec
Q9BTP9
resolver
amino_acid_sequence
MGTQALQGFLFLLFLPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSCHMPGYLGCFVDSGAPPALSGPSGTSTKLTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDLARGRLAPATDCDQICFGHPGQLCGGDGRLGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALGPPGAALELTFRLFELADPRDRLELRDAASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQDAAEDPEAPEGSAQTPAAPLDGANVSCSPRPGAPPAAIGARVFSTVTAVSVLLLLLLGLLRPLRRRSCLLAPGKGPPALGASRGPRRSWAVWYQQPRGVALPCSPGDPQAEGSAAGYRPLSASSQSSLRSLISAL
uniprot
proteins
function
FUNCTION: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. {ECO:0000250|UniProtKB:Q8K1S7}.
uniprot
proteins
mass_dalton
48849
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 365..387; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins