EIF3C
entrez
8663
canonical
uniprot
Q99613
canonical
ensembl
ENSG00000184110
resolver
ensp
ENSP00000332604
resolver
ensp
ENSP00000378953
resolver
ensp
ENSP00000456416
resolver
ensp
ENSP00000457418
resolver
ensp
ENSP00000457963
resolver
genesymbol
EIF3C
resolver
genesymbol_syn
EIF3S8
resolver
hgnc
HGNC:3279
resolver
uniprot
A8K7Z0
resolver
uniprot
B2RXG3
resolver
uniprot
B4E1D5
resolver
uniprot
H3BRV0
resolver
uniprot
O00215
resolver
uniprot
Q9BW98
resolver
uniprot_entry
EIF3C_HUMAN
resolver
uniprot_sec
A8K7Z0
resolver
uniprot_sec
B2RXG3
resolver
uniprot_sec
B4E1D5
resolver
uniprot_sec
H3BRV0
resolver
uniprot_sec
O00215
resolver
uniprot_sec
Q9BW98
resolver
amino_acid_sequence
MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEGSSDEDEDEDGVSAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRFLKKAPTTDEDKKAAEKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRAAQIELLQLLVQIAAENNLGEGVIVKIKFNIIASLYDYNPNLATYMKPEMWGKCLDCINELMDILFANPNIFVGENILEESENLHNADQPLRVRGCILTLVERMDEEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEVCRIYLLRILHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKNEGYMRRGGYRQQQSQTAY
uniprot
proteins
function
FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.
uniprot
proteins
mass_dalton
105344
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation is enhanced upon serum stimulation. {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17322308}.
uniprot
proteins
protein_family
EIF-3 subunit C family
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
14519125
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
15703437
uniprot
proteins
pubmed
16023166
uniprot
proteins
pubmed
16286006
uniprot
proteins
pubmed
16322461
uniprot
proteins
pubmed
16766523
uniprot
proteins
pubmed
16973618
uniprot
proteins
pubmed
17322308
uniprot
proteins
pubmed
17468741
uniprot
proteins
pubmed
17581632
uniprot
proteins
pubmed
18599441
uniprot
proteins
pubmed
19541769
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23145062
uniprot
proteins
pubmed
25849773
uniprot
proteins
pubmed
27462815
uniprot
proteins
pubmed
34260931
uniprot
proteins
pubmed
8995409
uniprot
proteins
sequence_length
913
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
uniprot
proteins