Tbr1
entrez
21375
canonical
uniprot
Q64336
canonical
ensembl
ENSMUSG00000035033
resolver
ensp
ENSMUSP00000046787
resolver
ensp
ENSMUSP00000099798
resolver
enst
ENSMUST00000048934
resolver
enst
ENSMUST00000102737
resolver
genesymbol
Tbr1
resolver
uniprot
A2AR81
resolver
uniprot
Q7TSY9
resolver
uniprot_entry
A2AR81_MOUSE
resolver
uniprot_entry
TBR1_MOUSE
resolver
uniprot_sec
Q7TSY9
resolver
amino_acid_sequence
MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTDNLERSSPLKKITRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAADRYLLSQSSQPQSAATAPSAMFPYPSQHGPAHPAFSIGSPSRYMAHHPVITNGAYNSLLSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANNRLDFAASAYDTATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGAKSGSVLPCWPNSAAAAARMAGANPYLGEEAEGLAAERSPLAPAAEDAKPKDLSDSSWIETPSSIKSIDSSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLAQRDCEKNCAKDIGGYYGFYSHS
uniprot
proteins
function
FUNCTION: Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:11239428, PubMed:21285371, PubMed:9883721). As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (PubMed:21285371). {ECO:0000269|PubMed:11239428, ECO:0000269|PubMed:21285371, ECO:0000269|PubMed:9883721}.
uniprot
proteins
mass_dalton
73940
uniprot
proteins
pubmed
11239428
uniprot
proteins
pubmed
15066269
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21285371
uniprot
proteins
pubmed
7619531
uniprot
proteins
pubmed
9883721
uniprot
proteins
sequence_length
681
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q16650}.
uniprot
proteins