NQO1
entrez
1728
canonical
uniprot
P15559
canonical
ensembl
ENSG00000181019
resolver
ensp
ENSP00000319788
resolver
ensp
ENSP00000368334
resolver
ensp
ENSP00000368335
resolver
ensp
ENSP00000398330
resolver
enst
ENST00000439109
resolver
genesymbol
NQO1
resolver
genesymbol_syn
DIA4
resolver
genesymbol_syn
NMOR1
resolver
hgnc
HGNC:2874
resolver
uniprot
B2R5Y9
resolver
uniprot
B4DLR8
resolver
uniprot
B4DNM7
resolver
uniprot
B7ZAD1
resolver
uniprot
F6UQD8
resolver
uniprot
Q86UK1
resolver
uniprot_entry
B4DLR8_HUMAN
resolver
uniprot_entry
F6UQD8_HUMAN
resolver
uniprot_entry
NQO1_HUMAN
resolver
uniprot_sec
B2R5Y9
resolver
uniprot_sec
B4DNM7
resolver
uniprot_sec
B7ZAD1
resolver
uniprot_sec
Q86UK1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by dicoumarol. {ECO:0000269|PubMed:15687255, ECO:0000269|PubMed:9271353}.
uniprot
proteins
amino_acid_sequence
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
uniprot
proteins
ec_number
1.6.5.2
uniprot
proteins
function
FUNCTION: Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (By similarity) (PubMed:8999809, PubMed:9271353). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (PubMed:15102952, PubMed:8999809, PubMed:9271353). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (PubMed:8999809). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (PubMed:15687255, PubMed:28291250). {ECO:0000250|UniProtKB:P05982, ECO:0000269|PubMed:15102952, ECO:0000269|PubMed:15687255, ECO:0000269|PubMed:28291250, ECO:0000269|PubMed:8999809, ECO:0000269|PubMed:9271353}.
uniprot
proteins
mass_dalton
30868
uniprot
proteins
mutagenesis
MUTAGEN 105; /note="Q->Y: Decreases the catalytic efficiency toward menadione. Increases the affinity toward NADH. Increases the catalytic afficiency toward nitrobenzene substrate. Has no effect on the affinity toward NADH; when associated with V-204."; /evidence="ECO:0000269|PubMed:8999809"; MUTAGEN 129; /note="Y->F,V: Abolishes the interaction with TP73."; /evidence="ECO:0000269|PubMed:15687255"; MUTAGEN 204; /note="I->V: Has no effect on the affinity toward NADH; when associated with Y-105."; /evidence="ECO:0000269|PubMed:8999809
uniprot
proteins
protein_family
NAD(P)H dehydrogenase (quinone) family
uniprot
proteins
pubmed
10447260
uniprot
proteins
pubmed
10543876
uniprot
proteins
pubmed
10706635
uniprot
proteins
pubmed
11587640
uniprot
proteins
pubmed
11735396
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15102952
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
15687255
uniprot
proteins
pubmed
1657151
uniprot
proteins
pubmed
16700548
uniprot
proteins
pubmed
1737339
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21636573
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28291250
uniprot
proteins
pubmed
2843525
uniprot
proteins
pubmed
8999809
uniprot
proteins
pubmed
9271353
uniprot
proteins
sequence_length
274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P05982}.
uniprot
proteins