MGRN1
entrez
23295
canonical
uniprot
O60291
canonical
ensembl
ENSG00000102858
resolver
ensp
ENSP00000262370
resolver
ensp
ENSP00000382487
resolver
ensp
ENSP00000393311
resolver
ensp
ENSP00000468819
resolver
genesymbol
MGRN1
resolver
genesymbol_syn
KIAA0544
resolver
genesymbol_syn
RNF156
resolver
hgnc
HGNC:20254
resolver
uniprot
A4URL3
resolver
uniprot
A4URL4
resolver
uniprot
Q86W76
resolver
uniprot_entry
MGRN1_HUMAN
resolver
uniprot_sec
A4URL3
resolver
uniprot_sec
A4URL4
resolver
uniprot_sec
Q86W76
resolver
amino_acid_sequence
MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPALGPDSCSVGIDE
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H (PubMed:17229889, PubMed:19703557). Plays a role in the regulation of endosome-to-lysosome trafficking (PubMed:17229889). Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production (PubMed:19737927). Does not inhibit ADRB2-signaling (PubMed:19737927). Does not promote MC1R ubiquitination (PubMed:19737927). Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}.
uniprot
proteins
mass_dalton
60753
uniprot
proteins
mutagenesis
MUTAGEN 406..409; /note="PSAP->ASAA: Loss of TSG101-binding and drastic reduction of TSG101-ubiquitination."; /evidence="ECO:0000269|PubMed:17229889
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated in vitro. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17229889
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19703557
uniprot
proteins
pubmed
19737927
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20213681
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9628581
uniprot
proteins
sequence_length
552
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19737927}. Note=The endosomal localization is dependent on the interaction with TSG101. {ECO:0000269|PubMed:17229889}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:19737927}. Nucleus {ECO:0000269|PubMed:19737927}. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli. {ECO:0000269|PubMed:19737927}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:19737927}. Nucleus {ECO:0000269|PubMed:19737927}. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli. {ECO:0000269|PubMed:19737927}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytosol. Cell membrane.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm, cytosol. Cell membrane.
uniprot
proteins