Camsap2
entrez
289400
canonical
uniprot
D4AEC2
canonical
ensembl
ENSRNOG00000008741
resolver
ensembl
ENSRNOG00055020795
resolver
ensembl
ENSRNOG00060017052
resolver
ensp
ENSRNOP00000057155
resolver
ensp
ENSRNOP00000074249
resolver
ensp
ENSRNOP00000088623
resolver
ensp
ENSRNOP00055028814
resolver
ensp
ENSRNOP00060023485
resolver
enst
ENSRNOT00000091015
resolver
enst
ENSRNOT00055035525
resolver
enst
ENSRNOT00060029167
resolver
genesymbol
Camsap2
resolver
uniprot
A0A0G2K7K9
resolver
uniprot
A0A5H1ZRV8
resolver
uniprot_entry
A0A5H1ZRV8_RAT
resolver
uniprot_entry
CAMP2_RAT
resolver
uniprot_sec
A0A0G2K7K9
resolver
amino_acid_sequence
MGDAADPREVRRTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAFGTETVPEELREPFYTDQYDQEHIKPPVVNLLLSAELYCRAGSLILKSDAAKPLLGHDAVIQALAHKGLYVTDQEKLVTERDLHKKPIQMSAHLAMIDTLMMAYTVEMVSIEKVIACAQQYSAFFQATDLPYDIEDAVMYWINKVNEHLKDIMEQEQKSKEHHTAEAPGGQKSPSKWFWKLVPARYRKEQTLLKQLPCIPLVENLLKDGTDGCALAALIHFYCPAVVRLEDICLKETMSLADSLYNLQLIQEFCQEYLNHCCHFSLEDMLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPRVVRPQGAEPAKDMPSVPVLNAAKRNVLDSSSSSDFTSRYTRPQTHSSVSGGIRRSSSMSYVDGFIGTWPKEKRTSVHGVSFDISFDKEDNAQSSTPNRGIIRSVSNEGLNNSRASKHIRKNLSFKPVNGGEEESIEEELHVDPHGDLKSYMPLSTNELNSNENTHHKLPNGALQNRVLLDEFGNQIETPSIEEALQIIHDTEKPPHTARPDQIANGFFLHGQDLSLLNSNIKLSQSSPDNITDPKGALSPITDTTEVDTGIHVPSEDIPETMDEDSSLRDYTVSLDSDMDDASKFLQDYDIRASNPREALSPCPSTISTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGKSSGSSSQKTTPEGSELNIPHMVSWAQIPEESGVAQGRDTTQLLASEMVHLRMRLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRAKEKESQKMDGQRSKSLADIKESMENPQGKWLKSPSTPVDPEKQWNLTSPSEETLNEGELLEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPRQAGLSSAAAPFSADSPRPTHPSPQSSTRKSASFSVKNQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQKEPKPKEEIKKEPSECKGTLESCDHNPGEKEVKPLESTVSEVLSQPITETVCVTPNEDQLNQPTDPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVSVEKFDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAVKRAALLEKRLRREKETQLRKQQLEAEMEHRKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVAKQKKQRPKSIHRDHIESPKTPIKGPPVSSLSLASLNTGDTESVHSGKRTPRSESVEGFLSPSRCGSRNGEKDWENASTTSSVASGTEYTGPKLYKEPSAKSNKHIIQNALAHCCLAGKVNEGQKKKILEEMEKSDANNFLILFRDSGCQFRSLYTYCPETEEINKLTGIGPKSITKKMIEGLYKYNSDRKQFSHIPAKTLSASVDAITIHSHLWQTKRPVTPKKLLPTKA
uniprot
proteins
function
FUNCTION: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:24908486). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (By similarity). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (By similarity). In addition, it also reduces the velocity of microtubule polymerization (By similarity). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (By similarity). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (By similarity). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (By similarity). {ECO:0000250|UniProtKB:Q08AD1, ECO:0000269|PubMed:24908486}.
uniprot
proteins
mass_dalton
165612
uniprot
proteins
protein_family
CAMSAP1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24908486
uniprot
proteins
sequence_length
1470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q08AD1}. Golgi apparatus {ECO:0000250|UniProtKB:Q08AD1}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8C1B1}. Cytoplasm {ECO:0000250|UniProtKB:Q8C1B1}. Note=Associated with the minus-end of microtubules and also detected at the centrosomes. Decorates the minus-end of microtubules by decreasing the rate of tubulin incorporation and remaining bound. The length of CAMSAP2-decorated stretches on the minus-end of microtubules is dependent on MAPRE1/EB1 and MAPRE3/EB3, which promote elongation of CAMSAP2-decorated microtubule stretches. Recruited to the Golgi apparatus by AKAP9 and PDE4DIP. In neurons, localizes to the minus-end of microtubules in axon and dendrites. {ECO:0000250|UniProtKB:Q08AD1}.
uniprot
proteins