SH3RF2
entrez
153769
canonical
uniprot
Q8TEC5
canonical
ensembl
ENSG00000156463
resolver
ensp
ENSP00000352028
resolver
ensp
ENSP00000424497
resolver
ensp
ENSP00000529884
resolver
ensp
ENSP00000529886
resolver
genesymbol
SH3RF2
resolver
genesymbol_syn
POSH3
resolver
genesymbol_syn
POSHER
resolver
genesymbol_syn
PPP1R39
resolver
genesymbol_syn
RNF158
resolver
hgnc
HGNC:26299
resolver
uniprot
A8K961
resolver
uniprot
Q08AM8
resolver
uniprot
Q08AM9
resolver
uniprot
Q6GMR9
resolver
uniprot
Q8N5S8
resolver
uniprot
Q96LP8
resolver
uniprot_entry
Q08AM8_HUMAN
resolver
uniprot_entry
SH3R2_HUMAN
resolver
uniprot_sec
A8K961
resolver
uniprot_sec
Q08AM9
resolver
uniprot_sec
Q6GMR9
resolver
uniprot_sec
Q8N5S8
resolver
uniprot_sec
Q96LP8
resolver
amino_acid_sequence
MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRVFKAHKELRCPECRTPVFSNIEALPANLLLVRLLDGVRSGQSSGRGGSFRRPGTMTLQDGRKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVIKQLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVPSSCVGQVSTYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSSFPDSRSPGLYTTWTLSTSSVSSQGSISEGDPRQSRPFKSVFVPTAIVNPVRSTAGPGTLGQGSLRKGRSSMRKNGSLQRPLQSGIPTLVVGSLRRSPTMVLRPQQFQFYQPQGIPSSPSAVVVEMGSKPALTGEPALTCISRGSEAWIHSAASSLIMEDKEIPIKSEPLPKPPASAPPSILVKPENSRNGIEKQVKTVRFQNYSPPPTKHYTSHPTSGKPEQPATLKASQPEAASLGPEMTVLFAHRSGCHSGQQTDLRRKSALGKATTLVSTASGTQTVFPSK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19389623, PubMed:19945436). {ECO:0000269|PubMed:19389623, ECO:0000269|PubMed:19945436, ECO:0000269|PubMed:22128169, ECO:0000269|PubMed:24130170}.
uniprot
proteins
mass_dalton
79320
uniprot
proteins
mutagenesis
MUTAGEN 643; /note="V->G: Significant loss of interaction with PPP1CA. Significant loss of interaction with PPP1CA; when associated with G-645."; /evidence="ECO:0000269|PubMed:19945436"; MUTAGEN 645; /note="F->G: Significant loss of interaction with PPP1CA. Significant loss of interaction with PPP1CA; when associated with G-643."; /evidence="ECO:0000269|PubMed:19945436
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000269|PubMed:24130170}.
uniprot
proteins
protein_family
SH3RF family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19389623
uniprot
proteins
pubmed
19807924
uniprot
proteins
pubmed
19945436
uniprot
proteins
pubmed
20696164
uniprot
proteins
pubmed
22128169
uniprot
proteins
pubmed
24130170
uniprot
proteins
sequence_length
729
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24130170}.
uniprot
proteins