SMCY
entrez
8284
canonical
uniprot
Q9BY66
canonical
ensembl
ENSG00000012817
resolver
ensp
ENSP00000322408
resolver
ensp
ENSP00000372256
resolver
ensp
ENSP00000444293
resolver
ensp
ENSP00000563784
resolver
ensp
ENSP00000563789
resolver
ensp
ENSP00000563790
resolver
ensp
ENSP00000663558
resolver
ensp
ENSP00000663559
resolver
ensp
ENSP00000663560
resolver
genesymbol
KDM5D
resolver
genesymbol
SMCY
resolver
genesymbol_syn
HY
resolver
genesymbol_syn
HYA
resolver
genesymbol_syn
JARID1D
resolver
genesymbol_syn
KIAA0234
resolver
genesymbol_syn
SMCY
resolver
hgnc
HGNC:11115
resolver
uniprot
A0A384MR42
resolver
uniprot
A2RU19
resolver
uniprot
A6H8V7
resolver
uniprot
B4E1Y0
resolver
uniprot
B7ZLX1
resolver
uniprot
Q92509
resolver
uniprot
Q92809
resolver
uniprot
Q9HCU1
resolver
uniprot_entry
A0A384MR42_HUMAN
resolver
uniprot_entry
B4E1Y0_HUMAN
resolver
uniprot_entry
KDM5D_HUMAN
resolver
uniprot_sec
A2RU19
resolver
uniprot_sec
A6H8V7
resolver
uniprot_sec
B7ZLX1
resolver
uniprot_sec
Q92509
resolver
uniprot_sec
Q92809
resolver
uniprot_sec
Q9HCU1
resolver
amino_acid_sequence
MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVIEEGGYEAICKDRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHPFDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYGPGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGRKRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVARMDTPQLTLTELRVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERGQQLGVEVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDKARAELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQDWFHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYTSATACDPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLLPQLTGPVLELPEAIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSRALERRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLTPSTDHSPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL
uniprot
proteins
ec_number
1.14.11.67
uniprot
proteins
function
FUNCTION: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks. {ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320162, ECO:0000269|PubMed:17351630, ECO:0000269|PubMed:26747897, ECO:0000269|PubMed:27185910, ECO:0000269|PubMed:27427228, ECO:0000269|PubMed:27477906}.
uniprot
proteins
mass_dalton
174073
uniprot
proteins
mutagenesis
MUTAGEN 534; /note="H->A: Abolishes enzymatic activity; when associated with A-536."; /evidence="ECO:0000269|PubMed:17320162"; MUTAGEN 536; /note="E->A: Abolishes enzymatic activity; when associated with A-534."; /evidence="ECO:0000269|PubMed:17320162
uniprot
proteins
protein_family
JARID1 histone demethylase family
uniprot
proteins
pubmed
10861003
uniprot
proteins
pubmed
12815422
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17320160
uniprot
proteins
pubmed
17320162
uniprot
proteins
pubmed
17351630
uniprot
proteins
pubmed
18459961
uniprot
proteins
pubmed
26747897
uniprot
proteins
pubmed
27185910
uniprot
proteins
pubmed
27427228
uniprot
proteins
pubmed
27477906
uniprot
proteins
pubmed
8841177
uniprot
proteins
pubmed
9039502
uniprot
proteins
pubmed
9060413
uniprot
proteins
sequence_length
1539
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27185910, ECO:0000269|PubMed:27477906, ECO:0000305}.
uniprot
proteins