DIMT1
entrez
27292
canonical
uniprot
Q9UNQ2
canonical
ensembl
ENSG00000086189
resolver
ensp
ENSP00000199320
resolver
ensp
ENSP00000421754
resolver
enst
ENST00000199320
resolver
enst
ENST00000506390
resolver
genesymbol
DIMT1
resolver
genesymbol_syn
DIMT1L
resolver
hgnc
HGNC:30217
resolver
uniprot
A0A0C4DGB1
resolver
uniprot
A8K9K8
resolver
uniprot
O76025
resolver
uniprot
Q9BU77
resolver
uniprot
Q9UES1
resolver
uniprot_entry
A0A0C4DGB1_HUMAN
resolver
uniprot_entry
A8K9K8_HUMAN
resolver
uniprot_entry
DIM1_HUMAN
resolver
uniprot_sec
O76025
resolver
uniprot_sec
Q9BU77
resolver
uniprot_sec
Q9UES1
resolver
amino_acid_sequence
MPKVKSGAIGRRRGRQEQRRELKSAGGLMFNTGIGQHILKNPLIINSIIDKAALRPTDVVLEVGPGTGNMTVKLLEKAKKVVACELDPRLVAELHKRVQGTPVASKLQVLVGDVLKTDLPFFDTCVANLPYQISSPFVFKLLLHRPFFRCAILMFQREFALRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPPPPINFQEWDGLVRITFVRKNKTLSAAFKSSAVQQLLEKNYRIHCSVHNIIIPEDFSIADKIQQILTSTGFSDKRARSMDIDDFIRLLHGFNAEGIHFS
uniprot
proteins
ec_number
2.1.1.183
uniprot
proteins
function
FUNCTION: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:25851604, ECO:0000269|PubMed:34516797}.
uniprot
proteins
mass_dalton
35236
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
rRNA adenine N(6)-methyltransferase family
uniprot
proteins
pubmed
11124703
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25851604
uniprot
proteins
pubmed
34516797
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:25851604}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:25851604, ECO:0000269|PubMed:34516797}.
uniprot
proteins