Synb
entrez
239167
canonical
uniprot
Q8BI41
canonical
ensembl
ENSMUSG00000047977
resolver
ensembl
ENSMUSG00000098773
resolver
ensp
ENSMUSP00000061107
resolver
ensp
ENSMUSP00000139267
resolver
enst
ENSMUST00000059362
resolver
enst
ENSMUST00000184652
resolver
genesymbol
Synb
resolver
uniprot
V9GXQ5
resolver
uniprot_entry
SYNB_MOUSE
resolver
uniprot_sec
V9GXQ5
resolver
amino_acid_sequence
MTGFWVLCFVLFPSSLSYPESWMPLVNLTHHILRDTNSSLFSNCWVCLSTQTQRSLAVPAPLSIWTDTPMKLHLTYSVRPFSGSFSISDIERRLRLFRPLTASYSFHNPDRRAIAFLQLVSSTGIFRIITRITSVIYPHKDRFFESAQRPLWGPLFTETVLRSQAPLCISRFFKVSAYATFVGNLSASLCNYTMHISPSTSHENLDLSTTHTFKQAMKRPDAKWKNPLRFSGPPSLIFSKPAYYPCPTDIKHCHTSPATPWMHCPQAPFGTCYNLTLFEPDNSTHPVTMSVNPTHFKVKLQGHRDPYPLSHYQPLTGAALSGQYSVWENEITVQENWDITSNIFSHLLSFSYAFCLNSSGVFFLCGTSTYICLPANWSGVCTLVFQYPDIELLPNNQTVPVPLFASVLSSDSVLRPKRSPHLFPFLAGLGISSALGTGIAGLATSTLYFQQLSKVLSETLEEIAASITTLQNQIDSLAGVVLQNRRALDLITAEKGGTCLFLQEECCFYVNQSGIVRDAARKLQERASELGQHSDSWGQWPDLGRWLPWLTPFLGPLLFLFFLLTFGSCLLNCLTRFVSQRLGSFVQDTAKRHVDSILQNFQYKKLPQDSPDEDTIPT
uniprot
proteins
function
FUNCTION: This endogenous retroviral envelope protein has retained its original fusogenic properties (PubMed:15644441, PubMed:18077339, PubMed:22032925, PubMed:27589388). Together with Syna, participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis (PubMed:22032925). Synb is specifically involved in formation of syncytiotrophoblast layer II (SynT-II) (PubMed:22032925). Promotes myoblast fusion, and may play a role in regeneration of damaged muscle tissue in males (PubMed:27589388). May have immunosuppressive activity (PubMed:18077339). {ECO:0000269|PubMed:15644441, ECO:0000269|PubMed:18077339, ECO:0000269|PubMed:22032925}.
uniprot
proteins
mass_dalton
69514
uniprot
proteins
mutagenesis
MUTAGEN 495; /note="K->R: Loss of immunosuppressive activity. No effect on fusogenic activity."; /evidence="ECO:0000269|PubMed:18077339
uniprot
proteins
post_translational_modification
PTM: Synthesized as an inactive precursor that is heavily N-glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R. {ECO:0000250|UniProtKB:Q9UQF0}.; PTM: The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion. {ECO:0000250|UniProtKB:Q9UQF0}.
uniprot
proteins
protein_family
Gamma type-C retroviral envelope protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15644441
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18077339
uniprot
proteins
pubmed
18448564
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22032925
uniprot
proteins
pubmed
27589388
uniprot
proteins
sequence_length
618
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Surface protein]: Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250|UniProtKB:Q9UQF0}.; SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 546..566; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins