HORMAD2
entrez
150280
canonical
uniprot
Q8N7B1
canonical
ensembl
ENSG00000176635
resolver
ensp
ENSP00000336984
resolver
ensp
ENSP00000385055
resolver
ensp
ENSP00000800591
resolver
enst
ENST00000336726
resolver
enst
ENST00000403975
resolver
genesymbol
HORMAD2
resolver
hgnc
HGNC:28383
resolver
uniprot
B5MEB2
resolver
uniprot
Q8NHR2
resolver
uniprot_entry
HORM2_HUMAN
resolver
uniprot_sec
B5MEB2
resolver
uniprot_sec
Q8NHR2
resolver
amino_acid_sequence
MATAQLSHCITIHKASKETVFPSQITNEHESLKMVKKLFATSISCITYLRGLFPESSYGERHLDDLSLKILREDKKCPGSLHIIRWIQGCFDALEKRYLRMAVLTLYTDPMGSEKVTEMYQFKFKYTKEGATMDFDSHSSSTSFESGTNNEDIKKASVLLIRKLYILMQDLEPLPNNVVLTMKLHYYNAVTPHDYQPLGFKEGVNSHFLLFDKEPINVQVGFVSTGFHSMKVKVMTEATKVIDLENNLFRENSTTEIAHQGLDCDEEEECNDHIQRMNFVCSQQSSECSRKKRKVSEPVKVFIPNRK
uniprot
proteins
function
FUNCTION: Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
35284
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in a SPO11-dependent manner. {ECO:0000250}.
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15999985
uniprot
proteins
pubmed
22893617
uniprot
proteins
sequence_length
307
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22893617}. Chromosome {ECO:0000250}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the male and female prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes (By similarity). {ECO:0000250}.
uniprot
proteins