PANX2
entrez
56666
canonical
uniprot
Q96RD6
canonical
ensembl
ENSG00000073150
resolver
ensp
ENSP00000159647
resolver
ensp
ENSP00000379183
resolver
genesymbol
PANX2
resolver
genesymbol_syn
PANX
resolver
hgnc
HGNC:8600
resolver
uniprot
B3KTT7
resolver
uniprot
B7Z684
resolver
uniprot
Q495U3
resolver
uniprot
Q96RD5
resolver
uniprot
Q9UGX8
resolver
uniprot_entry
B3KTT7_HUMAN
resolver
uniprot_entry
PANX2_HUMAN
resolver
uniprot_entry
Q495U3_HUMAN
resolver
uniprot_sec
B7Z684
resolver
uniprot_sec
Q96RD5
resolver
uniprot_sec
Q9UGX8
resolver
amino_acid_sequence
MHHLLEQSADMATALLAGEKLRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSVQLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQTVDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPARRKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGTKKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLPSGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLYEAREEEDGGPRLPQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF
uniprot
proteins
function
FUNCTION: Ion channel with a slight anion preference (PubMed:36973289). Also able to release ATP (PubMed:36869038). Plays a role in regulating neurogenesis and apoptosis in keratinocytes (By similarity). {ECO:0000250|UniProtKB:Q6IMP4, ECO:0000269|PubMed:36869038, ECO:0000269|PubMed:36973289}.
uniprot
proteins
mass_dalton
74447
uniprot
proteins
mutagenesis
MUTAGEN 89; /note="R->A,E: Increases ATP permeation. Reduced currents. No effect on membrane location. No effect on ion selectivity."; /evidence="ECO:0000269|PubMed:36869038, ECO:0000269|PubMed:36973289"; MUTAGEN 89; /note="R->W: Reduced currents. No effect on membrane location. Loss of ion selectivity."; /evidence="ECO:0000269|PubMed:36973289
uniprot
proteins
post_translational_modification
PTM: S-palmitoylated in neural stem and progenitor cells. {ECO:0000250|UniProtKB:Q6IMP4}.; PTM: Cleaved by CASP3 and CASP7 during apoptosis. Cleavage has no effect on it function. {ECO:0000250|UniProtKB:Q6IMP4}.
uniprot
proteins
protein_family
Pannexin family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15028292
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
36869038
uniprot
proteins
pubmed
36973289
uniprot
proteins
sequence_length
677
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:36973289}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q6IMP4}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6IMP4}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Note=Localizes to Golgi apparatus and endoplasmic reticulum in multipotential neural stem and progenitor cells and to plasma membrane in terminally differentiated neurons. {ECO:0000250|UniProtKB:Q6IMP4}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..70; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"; TRANSMEM 124..146; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"; TRANSMEM 227..249; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"; TRANSMEM 293..315; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351
uniprot
proteins