Lsr
entrez
64355
canonical
uniprot
Q9WU74
canonical
ensembl
ENSRNOG00000021053
resolver
ensembl
ENSRNOG00055032506
resolver
ensembl
ENSRNOG00060032297
resolver
ensembl
ENSRNOG00065033475
resolver
ensp
ENSRNOP00000041379
resolver
genesymbol
Lsr
resolver
genesymbol_syn
Lisch7
resolver
uniprot
Q497B9
resolver
uniprot
Q9WU75
resolver
uniprot
Q9WU76
resolver
uniprot_entry
LSR_RAT
resolver
uniprot_sec
Q497B9
resolver
uniprot_sec
Q9WU75
resolver
uniprot_sec
Q9WU76
resolver
amino_acid_sequence
MAPAAGACAGAPDSHPATVVFVCLFLIIFCPDPASAIQVTVSDPYHVVILFQPVTLPCTYQMSNTLTVPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFEQTAWGDSGVYYCSVVSAQDLDGNNEAYAELIVLGRTSEAPELLPGFRAGPLEDWLFVVVVCLASLLLFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSIYTHLSPAKTPPPPPAMIPMGPPYGYPGDFDRHSSVGGHSSQVPLLRDVDGSVSSEVRSGYRIQANQQDDSMRVLYYMEKELANFDPSRPGPPNGRVERAMSEVTSLHEDDWRSRPSRAPALTPIRDEEWNRHSPQSPRTWEQEPLQEQPRGGWGSGRPRARSVDALDDINRPGSTESGRSSPPSSGRRGRAYAPPRSRSRDDLYDPDDPRDLPHSRDPHYYDDIRSRDPRADPRSRQRSRDPRDAGFRSRDPQYDGRLLEEALKKKGSGERRRVYREEEEEEEGQYPPAPPPYSETDSQASRERRLKKNLALSRESLVV
uniprot
proteins
function
FUNCTION: Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (PubMed:10224102). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000269|PubMed:10224102}.
uniprot
proteins
mass_dalton
65777
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-308 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions. {ECO:0000250|UniProtKB:Q99KG5}.; PTM: Polyubiquitinated at Lys-582 via 'Lys-63'-linked ubiquitin chains; deubiquitinated by USP53. {ECO:0000250|UniProtKB:Q86X29}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
LISCH7 family
uniprot
proteins
pubmed
10224102
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
593
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q99KG5}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q99KG5}. Note=Located at tricellular contacts. {ECO:0000250|UniProtKB:Q99KG5}.
uniprot
proteins
transmembrane_region
TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins