SLCO1B1
entrez
10599
canonical
uniprot
Q9Y6L6
canonical
ensembl
ENSG00000134538
resolver
ensp
ENSP00000256958
resolver
ensp
ENSP00000540241
resolver
ensp
ENSP00000540243
resolver
ensp
ENSP00000540248
resolver
enst
ENST00000256958
resolver
enst
ENST00000870182
resolver
enst
ENST00000870184
resolver
enst
ENST00000870189
resolver
genesymbol
SLCO1B1
resolver
genesymbol_syn
LST1
resolver
genesymbol_syn
OATP1B1
resolver
genesymbol_syn
OATP2
resolver
genesymbol_syn
OATPC
resolver
genesymbol_syn
SLC21A6
resolver
hgnc
HGNC:10959
resolver
uniprot
B2R7G2
resolver
uniprot
Q05CV5
resolver
uniprot
Q29R64
resolver
uniprot
Q9NQ37
resolver
uniprot
Q9UBF3
resolver
uniprot
Q9UH89
resolver
uniprot_entry
Q05CV5_HUMAN
resolver
uniprot_entry
SO1B1_HUMAN
resolver
uniprot_sec
B2R7G2
resolver
uniprot_sec
Q29R64
resolver
uniprot_sec
Q9NQ37
resolver
uniprot_sec
Q9UBF3
resolver
uniprot_sec
Q9UH89
resolver
amino_acid_sequence
MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASENGSVMDEANLESLNKNKHFVPSAGADSETHC
uniprot
proteins
disease_involvement
DISEASE: Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. {ECO:0000269|PubMed:22232210}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Mediates the Na(+)-independent uptake of organic anions (PubMed:10358072, PubMed:15159445, PubMed:17412826). Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine) (PubMed:10358072, PubMed:10601278, PubMed:10873595, PubMed:11159893, PubMed:12196548, PubMed:12568656, PubMed:15159445, PubMed:15970799, PubMed:16627748, PubMed:17412826, PubMed:19129463, PubMed:26979622). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop (PubMed:22232210). Involved in the clearance of endogenous and exogenous substrates from the liver (PubMed:10358072, PubMed:10601278). Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition (PubMed:26383540). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can transport HMG-CoA reductase inhibitors (also known as statins), such as pravastatin and pitavastatin, a clinically important class of hypolipidemic drugs (PubMed:10601278, PubMed:15159445, PubMed:15970799). May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drug methotrexate (PubMed:23243220). May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in the liver (PubMed:16624871, PubMed:16627748). Shows a pH-sensitive substrate specificity towards prostaglandin E2 and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). {ECO:0000269|PubMed:10358072, ECO:0000269|PubMed:10601278, ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:12196548, ECO:0000269|PubMed:12568656, ECO:0000269|PubMed:15159445, ECO:0000269|PubMed:15970799, ECO:0000269|PubMed:16624871, ECO:0000269|PubMed:16627748, ECO:0000269|PubMed:17412826, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:22232210, ECO:0000269|PubMed:23243220, ECO:0000269|PubMed:26383540, ECO:0000269|PubMed:26979622, ECO:0000305|PubMed:35307651}.
uniprot
proteins
mass_dalton
76449
uniprot
proteins
mutagenesis
MUTAGEN 367; /note="Y->F: Decreased estradiol-17beta-d-glucuronide uptake."; /evidence="ECO:0000269|PubMed:26979622"; MUTAGEN 625; /note="Y->F: Decreased estradiol-17beta-d-glucuronide uptake."; /evidence="ECO:0000269|PubMed:26979622"; MUTAGEN 645; /note="Y->F: Decreased estradiol-17beta-d-glucuronide uptake."; /evidence="ECO:0000269|PubMed:26979622
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
10358072
uniprot
proteins
pubmed
10601278
uniprot
proteins
pubmed
10644574
uniprot
proteins
pubmed
10779507
uniprot
proteins
pubmed
10873595
uniprot
proteins
pubmed
11159893
uniprot
proteins
pubmed
11477075
uniprot
proteins
pubmed
12130747
uniprot
proteins
pubmed
12196548
uniprot
proteins
pubmed
12568656
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15159445
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15970799
uniprot
proteins
pubmed
16624871
uniprot
proteins
pubmed
16627748
uniprot
proteins
pubmed
17412826
uniprot
proteins
pubmed
19129463
uniprot
proteins
pubmed
22232210
uniprot
proteins
pubmed
23243220
uniprot
proteins
pubmed
23285087
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26383540
uniprot
proteins
pubmed
26979622
uniprot
proteins
pubmed
35307651
uniprot
proteins
sequence_length
691
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12196548}; Multi-pass membrane protein {ECO:0000269|PubMed:12196548}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000305}. Note=Detected in basolateral membranes of hepatocytes (PubMed:12196548). Localized to the basal membrane of Sertoli cells (PubMed:35307651). {ECO:0000269|PubMed:12196548, ECO:0000269|PubMed:35307651}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..48; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 68..88; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 95..119; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 169..197; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 256..280; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 332..353; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 374..397; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 402..425; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 538..560; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 570..595; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 630..647; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins