Cdo1
entrez
81718
canonical
uniprot
P21816
canonical
ensembl
ENSRNOG00000000158
resolver
ensembl
ENSRNOG00055018164
resolver
ensembl
ENSRNOG00060011390
resolver
ensembl
ENSRNOG00065019206
resolver
ensp
ENSRNOP00000000172
resolver
ensp
ENSRNOP00055024784
resolver
ensp
ENSRNOP00060015111
resolver
ensp
ENSRNOP00065025845
resolver
enst
ENSRNOT00000000172
resolver
enst
ENSRNOT00055030795
resolver
enst
ENSRNOT00060019291
resolver
enst
ENSRNOT00065032348
resolver
genesymbol
Cdo1
resolver
uniprot
Q6NS32
resolver
uniprot_entry
CDO1_RAT
resolver
uniprot_sec
Q6NS32
resolver
amino_acid_sequence
MERTELLKPRTLADLIRILHELFAGDEVNVEEVQAVLEAYESNPAEWALYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLRENQCAYINDSIGLHRVENVSHTEPAVSLHLYSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTPFTTSGSLENN
uniprot
proteins
ec_number
1.13.11.20
uniprot
proteins
function
FUNCTION: Rate-limiting enzyme of the cysteine catabolic process to taurine, which catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen. {ECO:0000269|PubMed:9824269}.
uniprot
proteins
mass_dalton
23026
uniprot
proteins
pathway_participation
PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2. {ECO:0000269|PubMed:9824269}.
uniprot
proteins
post_translational_modification
PTM: The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen. {ECO:0000269|PubMed:16611640}.; PTM: Ubiquitinated and degraded by the ECS(LRRC58) complex, leading to its degradation. L-cysteine abundance regulates ECS(LRRC58)-mediated ubiquitination of CDO1: the complex promotes ubiquitination and degradation of CDO1 in presence of high level of cysteine, but not when cysteine abundance is low. {ECO:0000250|UniProtKB:Q16878}.
uniprot
proteins
protein_family
Cysteine dioxygenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16611640
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2334417
uniprot
proteins
pubmed
8973325
uniprot
proteins
pubmed
9824269
uniprot
proteins
sequence_length
200
uniprot
proteins