Nppb
entrez
18158
canonical
uniprot
P40753
canonical
ensembl
ENSMUSG00000029019
resolver
ensp
ENSMUSP00000099521
resolver
ensp
ENSMUSP00000255925
resolver
genesymbol
Nppb
resolver
uniprot
Q54AE9
resolver
uniprot_entry
ANFB_MOUSE
resolver
uniprot_entry
Q54AE9_MOUSE
resolver
amino_acid_sequence
MDLLKVLSQMILFLLFLYLSPLGGHSYPLGSPSQSPEQFKMQKLLELIREKSEEMAQRQLLKDQGLTKEHPKRVLRSQGSTLRVQQRPQNSKVTHISSCFGHKIDRIGSVSRLGCNALKLL
uniprot
proteins
function
FUNCTION: [Brain natriuretic peptide 45]: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed:8182124). May also function as a paracrine antifibrotic factor in the heart (PubMed:10737768). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:8182124). Likely involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, kaluresis and chloruresis (By similarity). {ECO:0000250|UniProtKB:P13205, ECO:0000269|PubMed:10737768, ECO:0000269|PubMed:8182124}.
uniprot
proteins
mass_dalton
13756
uniprot
proteins
post_translational_modification
PTM: The precursor molecule is proteolytically cleaved by the endoprotease Furin to produce brain natriuretic peptide 45 (By similarity). May undergo further proteolytic cleavage by various proteases such as DPP4, MME and possibly FAP, to give rise to a variety of shorter peptides (By similarity). May be cleaved at Ser-91 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (By similarity). May be degraded by IDE (By similarity). During IDE degradation, the resulting products initially increase the activation of NPR1 and can also stimulate NPR2 to produce cGMP before the fragments are completely degraded and inactivated by IDE (in vitro) (By similarity). {ECO:0000250|UniProtKB:P13205, ECO:0000250|UniProtKB:P16860}.
uniprot
proteins
protein_family
Natriuretic peptide family
uniprot
proteins
pubmed
10737768
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8097440
uniprot
proteins
pubmed
8182124
uniprot
proteins
sequence_length
121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Brain natriuretic peptide 45]: Secreted {ECO:0000269|PubMed:8182124}. Note=Detected in blood. {ECO:0000269|PubMed:8182124}.
uniprot
proteins