Camk2b
entrez
24245
canonical
uniprot
P08413
canonical
ensembl
ENSRNOG00000052080
resolver
ensp
ENSRNOP00000058882
resolver
ensp
ENSRNOP00000068938
resolver
ensp
ENSRNOP00000084286
resolver
enst
ENSRNOT00000067162
resolver
genesymbol
Camk2b
resolver
genesymbol_syn
Camk2g
resolver
uniprot
F1LUE2
resolver
uniprot
Q63094
resolver
uniprot_entry
F1LUE2_RAT
resolver
uniprot_entry
KCC2B_RAT
resolver
uniprot_entry
Q63094_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
uniprot
proteins
amino_acid_sequence
MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTKNSSAITSPKGSLPPAALEPQTTVIHNPVDGIKESSDSTNTTIEDEDAKARKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRPDGKWQNVHFHCSGAPVAPLQ
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:12873385, PubMed:15312654). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise (PubMed:17272343). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-134' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (By similarity). {ECO:0000250|UniProtKB:Q13554, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:12873385, ECO:0000269|PubMed:15312654, ECO:0000269|PubMed:17272343}.
uniprot
proteins
mass_dalton
60402
uniprot
proteins
mutagenesis
MUTAGEN 43; /note="K->R: Catalytically inactive form."; /evidence="ECO:0000269|PubMed:12873385"; MUTAGEN 287; /note="T->D: Constitutively active form."; /evidence="ECO:0000269|PubMed:12873385"; MUTAGEN 303; /note="A->R: Blocks calcium/calmodulin binding."; /evidence="ECO:0000269|PubMed:12873385
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state. {ECO:0000269|PubMed:17272343}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11182241
uniprot
proteins
pubmed
11972023
uniprot
proteins
pubmed
12873385
uniprot
proteins
pubmed
15312654
uniprot
proteins
pubmed
16891908
uniprot
proteins
pubmed
17272343
uniprot
proteins
pubmed
22579289
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
3470758
uniprot
proteins
pubmed
9724800
uniprot
proteins
pubmed
9768845
uniprot
proteins
sequence_length
542
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Synapse {ECO:0000269|PubMed:22579289}. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the cortical actin cytoskeleton by binding to F-actin in hippocampal cells.
uniprot
proteins