Esrra
entrez
26379
canonical
uniprot
O08580
canonical
ensembl
ENSMUSG00000024955
resolver
ensp
ENSMUSP00000025906
resolver
enst
ENSMUST00000025906
resolver
genesymbol
Esrra
resolver
genesymbol_syn
Err1
resolver
genesymbol_syn
Estrra
resolver
genesymbol_syn
Nr3b1
resolver
uniprot
B2RRU9
resolver
uniprot
Q3U110
resolver
uniprot_entry
ERR1_MOUSE
resolver
uniprot_sec
B2RRU9
resolver
uniprot_sec
Q3U110
resolver
amino_acid_sequence
MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVTLASGPAPARCLPGHKEEEDGEGAGSGEQGSGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAPVNALVSHLLVVEPEKLYAMPDPASPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGDLGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD
uniprot
proteins
function
FUNCTION: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
45464
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity. {ECO:0000250}.; PTM: Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding (By similarity). {ECO:0000250}.; PTM: Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
NR3 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
14585956
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18063693
uniprot
proteins
pubmed
20484414
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21190936
uniprot
proteins
pubmed
28572090
uniprot
proteins
pubmed
9271417
uniprot
proteins
pubmed
9460651
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P11474, ECO:0000255|PROSITE-ProRule:PRU00407}. Cytoplasm {ECO:0000250|UniProtKB:P11474}. Note=Co-localizes to the cytoplasm only in presence of MAPK15. {ECO:0000250|UniProtKB:P11474}.
uniprot
proteins