A2TGX5
uniprot
A2TGX5
canonical
amino_acid_sequence
MTQLASAVWPPTLLLLLLFWVPGCVPLRGPSSVTGTVGESLNVTCQYEERFKMNKKYWCRGSLVLLCKDIVRTGGSEEARNGRVSIRDDRDNLTFTVTLQNLTLEDAGTYMCAVDIPLIDHSFKVELSVVPGNIPVSSPGTTRETTVVPTSFSTKGPTQGSIPEGHHEHYEPQGLSLPVLLSVLALLLLLLVGTSLLAWRMFQKRSVKADKHPEMSQNLRQAEEQSESQYVNLQLHTLPLREEPVPPSQVEVEYSTLALPQEELHYTSVVFDSQRQNSHANGDPPCQSPDQKTEYSEIRKPREGLSDPHP
uniprot
proteins
function
FUNCTION: Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. {ECO:0000250|UniProtKB:Q9UGN4}.
uniprot
proteins
mass_dalton
34495
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine. {ECO:0000250|UniProtKB:Q6SJQ0}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q6SJQ0}.
uniprot
proteins
protein_family
CD300 family
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6SJQ0}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q6SJQ0}.
uniprot
proteins
transmembrane_region
TRANSMEM 179..199; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins