FOXH1
entrez
8928
canonical
uniprot
O75593
canonical
ensembl
ENSG00000160973
resolver
ensp
ENSP00000366534
resolver
enst
ENST00000377317
resolver
genesymbol
FOXH1
resolver
genesymbol_syn
FAST1
resolver
genesymbol_syn
FAST2
resolver
hgnc
HGNC:3814
resolver
uniprot
D3DWM4
resolver
uniprot_entry
FOXH1_HUMAN
resolver
uniprot_sec
D3DWM4
resolver
amino_acid_sequence
MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYLAMIALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNGGARGAFAKDLGPYVLHGRPYRPPSPPPPPSEGFSIKSLLGGSGEGAPWPGLAPQSSPVPAGTGNSGEEAVPTPPLPSSERPLWPLCPLPGPTRVEGETVQGGAIGPSTLSPEPRAWPLHLLQGTAVPGGRSSGGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSPAYWGVAPETRGPPGLLCDLDALFQGVPPNKSIYDVWVSHPRDLAAPGPGWLLSWCSL
uniprot
proteins
function
FUNCTION: Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). {ECO:0000269|PubMed:9702198}.
uniprot
proteins
mass_dalton
39257
uniprot
proteins
mutagenesis
MUTAGEN 83; /note="H->R: Loss of activity."; /evidence="ECO:0000269|PubMed:9702198
uniprot
proteins
pubmed
9702198
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins