Cd53
entrez
12508
canonical
uniprot
Q61451
canonical
ensembl
ENSMUSG00000040747
resolver
ensp
ENSMUSP00000035781
resolver
enst
ENSMUST00000038845
resolver
genesymbol
Cd53
resolver
uniprot
Q3TV80
resolver
uniprot
Q3U0W1
resolver
uniprot
Q61721
resolver
uniprot_entry
CD53_MOUSE
resolver
uniprot_entry
Q3TV80_MOUSE
resolver
uniprot_entry
Q3U0W1_MOUSE
resolver
uniprot_sec
Q61721
resolver
amino_acid_sequence
MGMSSLKLLKYVLFIFNLLFWVCGCCILGFGIYFLVQNTYGVLFRNLPFLTLGNILVIVGSIIMVVAFLGCMGSIKENKCLLMSFFVLLLIILLAEVTIAILLFVYEQKLNTLVAEGLNDSIQHYHSDNSTMKAWDFIQTQLQCCGVNGSSDWTSGPPSSCPSGADVQGCYNKAKSWFHSNFLYIGIITICVCVIQVLGMSFALTLNCQIDKTSQALGL
uniprot
proteins
function
FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling (PubMed:36581203). Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (PubMed:32428859, PubMed:32532837). Plays a role in the activation of monocytes and B-cells (By similarity). Acts as an essential regulator of B-cell development by promoting interleukin-7 receptor/IL7R signaling (PubMed:31748347). Also promotes, in B-cells, the BCR signaling by recruiting PKC to the plasma membrane in order to phosphorylate its substrates (By similarity). Plays an essential role in lymphocyte homing to lymph nodes by stabilizing L-selectin/SELL cell surface expression (PubMed:32428859). Also mediates metabolic and inflammatory functions in hepatocytes and adipose tissue by promoting TNF and LPS signaling independent of the immune compartment (PubMed:36581203). Protects hematopoietic stem cell function in response to stress by facilitating DREAM complex activity through association with p130/RBL2 and its phosphatase PP2A (PubMed:36542833). {ECO:0000250|UniProtKB:P19397, ECO:0000269|PubMed:22847234, ECO:0000269|PubMed:31748347, ECO:0000269|PubMed:32428859, ECO:0000269|PubMed:32532837, ECO:0000269|PubMed:36542833, ECO:0000269|PubMed:36581203}.
uniprot
proteins
mass_dalton
24164
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22847234
uniprot
proteins
pubmed
31748347
uniprot
proteins
pubmed
32428859
uniprot
proteins
pubmed
32532837
uniprot
proteins
pubmed
36542833
uniprot
proteins
pubmed
36581203
uniprot
proteins
pubmed
8452817
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22847234, ECO:0000269|PubMed:31748347, ECO:0000269|PubMed:36542833}. Cell junction {ECO:0000269|PubMed:22847234}. Membrane {ECO:0000269|PubMed:22847234}; Multi-pass membrane protein {ECO:0000269|PubMed:22847234}. Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes. {ECO:0000269|PubMed:22847234}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 55..69; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 81..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 182..206; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins