Six3
entrez
20473
canonical
uniprot
Q62233
canonical
ensembl
ENSMUSG00000038805
resolver
ensp
ENSMUSP00000135312
resolver
genesymbol
Six3
resolver
uniprot
P70176
resolver
uniprot
P70177
resolver
uniprot
Q4QQQ3
resolver
uniprot_entry
SIX3_MOUSE
resolver
uniprot_sec
P70176
resolver
uniprot_sec
P70177
resolver
uniprot_sec
Q4QQQ3
resolver
amino_acid_sequence
MVFRSPLDLYSSHFLLPNFADSHHCSLLLASSGGGSGASGGGGGAGGGGGGNRAGGGGAGGAGGGSGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSSLTERADTGTSILSVTSSDSECDV
uniprot
proteins
function
FUNCTION: Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon (PubMed:18094027). Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression (PubMed:18775421). In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration (PubMed:22071110). Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2 (PubMed:17576749). During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm (PubMed:17066077). In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation (PubMed:12072567). Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory (PubMed:20890044). Its action during retina development and lens morphogenesis is TLE5 and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element (PubMed:11139622). Directly activates RHO transcription, or cooperates with CRX or NRL (PubMed:17666527). Six3 also functions in the formation of the proximodistal axis of the optic cup (PubMed:12163408), and promotes the formation of optic vesicles-like structures (PubMed:11458394). During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (PubMed:18694563). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway (By similarity). {ECO:0000250|UniProtKB:O95343, ECO:0000269|PubMed:11139622, ECO:0000269|PubMed:11458394, ECO:0000269|PubMed:12050133, ECO:0000269|PubMed:12072567, ECO:0000269|PubMed:12163408, ECO:0000269|PubMed:12569128, ECO:0000269|PubMed:17066077, ECO:0000269|PubMed:17576749, ECO:0000269|PubMed:17666527, ECO:0000269|PubMed:18094027, ECO:0000269|PubMed:18694563, ECO:0000269|PubMed:18775421, ECO:0000269|PubMed:20682799, ECO:0000269|PubMed:20890044, ECO:0000269|PubMed:22071110}.
uniprot
proteins
mass_dalton
35593
uniprot
proteins
mutagenesis
MUTAGEN 88; /note="F->E: Loss of interaction with TLE5 and TLE4."; /evidence="ECO:0000269|PubMed:12050133"; MUTAGEN 233..235; /note="Missing: Suppression of SIX3-binding to rhodopsin promoter. Impairs the ability of Six3 to stimulate RHO transcription."; /evidence="ECO:0000269|PubMed:17666527
uniprot
proteins
protein_family
SIX/Sine oculis homeobox family
uniprot
proteins
pubmed
11139622
uniprot
proteins
pubmed
11458394
uniprot
proteins
pubmed
12050133
uniprot
proteins
pubmed
12072567
uniprot
proteins
pubmed
12163408
uniprot
proteins
pubmed
12569128
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16024294
uniprot
proteins
pubmed
17066077
uniprot
proteins
pubmed
17576749
uniprot
proteins
pubmed
17666527
uniprot
proteins
pubmed
18094027
uniprot
proteins
pubmed
18694563
uniprot
proteins
pubmed
18775421
uniprot
proteins
pubmed
19606496
uniprot
proteins
pubmed
20682799
uniprot
proteins
pubmed
20890044
uniprot
proteins
pubmed
22071110
uniprot
proteins
pubmed
23792023
uniprot
proteins
pubmed
8575305
uniprot
proteins
pubmed
8814301
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12050133}.
uniprot
proteins