Dctn4
entrez
84428
canonical
uniprot
Q9QUR2
canonical
ensembl
ENSRNOG00000019298
resolver
ensembl
ENSRNOG00055013924
resolver
ensembl
ENSRNOG00060025735
resolver
ensembl
ENSRNOG00065022777
resolver
ensp
ENSRNOP00000026394
resolver
genesymbol
Dctn4
resolver
uniprot
Q498N3
resolver
uniprot
Q9QXP8
resolver
uniprot_entry
DCTN4_RAT
resolver
uniprot_entry
Q498N3_RAT
resolver
uniprot_sec
Q9QXP8
resolver
amino_acid_sequence
MASLLQSERVLYLVQGEKKVRAPLSQLYFCRYCSELRSLECVSHEVDSHYCPSCLENMPSAEAKLKKNRCANCFDCPGCMHTLSTRATSISTQLPDDPAKTTMKKAYYLACGFCRWTSRDVGMADKSVASGGWQEPENPHAQRMNKLIEYYQQLAQKEKVERDRKKLARRRNYMPLAFSQHTIHVVDKYSLGTRLQRPRAGASISTLAGLSLREGEDQKEVKIEPAQAVAEVEPLPEDYYTRPVNLTEVTTLQQRLLQPDLQPVSASQLYPRHKHLLIKRSLRCRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLLECEEGDPDNINSTAKVVVPPKELILAGKDAAAEYDELAEPQDFQDDPDIVAFRKANKVGIFIKVTPQREEGDVTVCFKMKHDFKNLAAPIRPMEESDQGTEVIWLTQHVELSFGPLLP
uniprot
proteins
function
FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:A0A4X1TB62}.
uniprot
proteins
mass_dalton
53089
uniprot
proteins
protein_family
Dynactin subunit 4 family
uniprot
proteins
pubmed
10525537
uniprot
proteins
pubmed
10607597
uniprot
proteins
pubmed
16641100
uniprot
proteins
sequence_length
467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9UJW0}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9UJW0}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:10607597}. Cytoplasm, cell cortex {ECO:0000269|PubMed:10607597}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q8CBY8}. Note=Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin (By similarity). Overexpression in cultured mammalian cells revealed colocalization with cortical actin, stress fibers, and focal adhesion sites, sites of potential interaction between microtubules and the cell cortex (PubMed:10607597). In skeletal muscles, costamere localization requires the presence of ANK2 (By similarity). {ECO:0000250|UniProtKB:Q8CBY8, ECO:0000250|UniProtKB:Q9UJW0, ECO:0000269|PubMed:10607597}.
uniprot
proteins