Pdx1
entrez
29535
canonical
uniprot
P52947
canonical
ensembl
ENSRNOG00000046458
resolver
ensembl
ENSRNOG00055003991
resolver
ensembl
ENSRNOG00060002478
resolver
ensembl
ENSRNOG00065006191
resolver
ensp
ENSRNOP00000066935
resolver
ensp
ENSRNOP00055004851
resolver
ensp
ENSRNOP00060002797
resolver
ensp
ENSRNOP00065006769
resolver
enst
ENSRNOT00000071942
resolver
enst
ENSRNOT00055006357
resolver
enst
ENSRNOT00060003967
resolver
enst
ENSRNOT00065009447
resolver
genesymbol
Pdx1
resolver
genesymbol_syn
Ipf1
resolver
uniprot_entry
PDX1_RAT
resolver
amino_acid_sequence
MNSEEQYYAATQLYKDPCAFQRGPVPEFSANPPACLYMGRQPPPPPPPQFAGSLGTLEQGSPPDISPYEVPPLADDPAGAHLHHHLPAQLGLAHPPPGPFPNGTETGGLEEPSRVHLPFPWMKSTKAHAWKSQWAGGAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRSSGTTSGGGGGEEPEQDCAVTSGEELLALPPPPPPGGAVPSGVPAAAREGRLPSGLSASPQPSSIAPLRPQEPR
uniprot
proteins
function
FUNCTION: Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'.
uniprot
proteins
mass_dalton
30831
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. Phosphorylated by HIPK2 on Ser-268 upon glucose accumulation. This phosphorylation mediates subnuclear localization shifting. Phosphorylation by PASK may lead to translocation into the cytosol (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Antp homeobox family
uniprot
proteins
protein_family
IPF1/XlHbox-8 subfamily
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7505393
uniprot
proteins
pubmed
7907546
uniprot
proteins
sequence_length
283
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. Cytoplasm, cytosol {ECO:0000250}.
uniprot
proteins