Mef2d
entrez
17261
canonical
uniprot
Q63943
canonical
ensembl
ENSMUSG00000001419
resolver
ensp
ENSMUSP00000001455
resolver
ensp
ENSMUSP00000103183
resolver
ensp
ENSMUSP00000103184
resolver
ensp
ENSMUSP00000113638
resolver
ensp
ENSMUSP00000289419
resolver
ensp
ENSMUSP00000289422
resolver
ensp
ENSMUSP00000289431
resolver
ensp
ENSMUSP00000289434
resolver
ensp
ENSMUSP00000289435
resolver
ensp
ENSMUSP00000289438
resolver
ensp
ENSMUSP00000289449
resolver
ensp
ENSMUSP00000289451
resolver
ensp
ENSMUSP00000289453
resolver
ensp
ENSMUSP00000289455
resolver
enst
ENSMUST00000001455
resolver
enst
ENSMUST00000107558
resolver
enst
ENSMUST00000119251
resolver
genesymbol
Mef2d
resolver
uniprot
E9Q5E0
resolver
uniprot
E9QKS9
resolver
uniprot
E9QKT0
resolver
uniprot
F6T3G9
resolver
uniprot
Q63944
resolver
uniprot
Q921S6
resolver
uniprot_entry
E9Q5E0_MOUSE
resolver
uniprot_entry
E9QKT0_MOUSE
resolver
uniprot_entry
F6T3G9_MOUSE
resolver
uniprot_entry
MEF2D_MOUSE
resolver
uniprot_entry
Q921S6_MOUSE
resolver
uniprot_sec
E9QKS9
resolver
uniprot_sec
Q63944
resolver
amino_acid_sequence
MGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYASTDMDKVLLKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPDGEDSLEQSPLLEDKYRRASEELDGLFRRYGSSVPAPNFAMPVTVPVSNQSSMQFSNPSSSLVTPSLVTSSLTDPRLLSPQQPALQRNSVSPGLPQRPASAGAMLGGDLNSANGACPSPVGNGYVSARASPGLLPVANGNSLNKVIPAKSPPPPTHNTQLGAPSRKPDLRVITSQGGKGLMHHLTEDHLDLNNAQRLGVSQSTHSLTTPVVSVATPSLLSQGLPFSSMPTAYNTDYQLPSAELSSLPAFSSPAGLALGNVTAWQQPQPPQQPQPPQPPQSQPQPPQPQPQQPPQQQPHLVPVSLSNLIPGSPLPHVGAALTVTTHPHISIKSEPVSPSRERSPAPPPPAVFPAARPEPGEGLSSPAGGSYETGDRDDGRGDFGPTLGLLRPAPEPEAEGSAVKRMRLDTWTLK
uniprot
proteins
function
FUNCTION: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis. {ECO:0000269|PubMed:16407541, ECO:0000269|PubMed:18299387}.
uniprot
proteins
mass_dalton
55065
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="T->A: No change in DNA-binding activity."; /evidence="ECO:0000269|PubMed:18299387"; MUTAGEN 20; /note="T->D: Dramatic decrease in DNA-binding."; /evidence="ECO:0000269|PubMed:18299387"; MUTAGEN 121; /note="S->A: Abolishes phosphorylation by PKA. No change in protein levels. Loss of protein stability on PKA stimulation. Loss of PKA-mediated repression. No change in interaction with HDAC4 in response to PKA; when associated with A-190."; /evidence="ECO:0000269|PubMed:18299387"; MUTAGEN 190; /note="S->A: Abolishes phosphorylation by PKA. No change in protein levels. Loss of protein stability on PKA stimulation mediated repression. No change in interaction with HDAC4 in response to PKA; when associated with A-121."; /evidence="ECO:0000269|PubMed:18299387"; MUTAGEN 437; /note="S->A: Loss of calpain/Cdk5-mediated neuron apoptosis."; /evidence="ECO:0000269|PubMed:16407541
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-437 is which is required for Lys-432 sumoylation and inhibits transcriptional activity. Phosphorylation on this residue by CDK5 is dependent on p35 and calpains. Phosphorylated by PKA at Ser-121 and Ser-190 represses transcriptional activity in embryonic and postnatal skeletal muscle, and stabilizes protein levels. No in vitro phosphorylation by PKA on Thr-20. Phosphorylated and activated by CaMK4 (By similarity). {ECO:0000250}.; PTM: Acetylated on Lys-432 by CREBBP. Acetylated by EP300. Deacetylated by SIRT1 and HDAC3 (By similarity). {ECO:0000250|UniProtKB:Q14814}.; PTM: Sumoylated on Lys-432 with SUMO2 but not SUMO1; which inhibits transcriptional activity and myogenic activity. Desumoylated by SENP3 (By similarity). {ECO:0000250}.; PTM: Proteolytically cleaved in cerebellar granule neurons by caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.
uniprot
proteins
protein_family
MEF2 family
uniprot
proteins
pubmed
15834131
uniprot
proteins
pubmed
16166628
uniprot
proteins
pubmed
16407541
uniprot
proteins
pubmed
16424906
uniprot
proteins
pubmed
18299387
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8114702
uniprot
proteins
pubmed
9013788
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:18299387}. Note=Translocated by HDAC4 to nuclear dots. {ECO:0000250}.
uniprot
proteins