SIAH3
entrez
283514
canonical
uniprot
Q8IW03
canonical
ensembl
ENSG00000215475
resolver
ensp
ENSP00000383256
resolver
enst
ENST00000400405
resolver
genesymbol
SIAH3
resolver
hgnc
HGNC:30553
resolver
uniprot
B7ZBP0
resolver
uniprot
Q8N8M6
resolver
uniprot_entry
SIAH3_HUMAN
resolver
uniprot_sec
B7ZBP0
resolver
uniprot_sec
Q8N8M6
resolver
amino_acid_sequence
MLFFTQCFGAVLDLIHLRFQHYKAKRVFSAAGQLVCVVNPTHNLKYVSSRRAVTQSAPEQGSFHPHHLSHHHCHHRHHHHLRHHAHPHHLHHQEAGLHANPVTPCLCMCPLFSCQWEGRLEVVVPHLRQIHRVDILQGAEIVFLATDMHLPAPADWIIMHSCLGHHFLLVLRKQERHEGHPQFFATMMLIGTPTQADCFTYRLELNRNHRRLKWEATPRSVLECVDSVITDGDCLVLNTSLAQLFSDNGSLAIGIAITATEVLPSEAEM
uniprot
proteins
function
FUNCTION: Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria. {ECO:0000269|PubMed:24270810}.
uniprot
proteins
mass_dalton
30660
uniprot
proteins
protein_family
SINA (Seven in absentia) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24270810
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:24270810}.
uniprot
proteins