SORCS3
entrez
22986
canonical
uniprot
Q9UPU3
canonical
ensembl
ENSG00000156395
resolver
ensp
ENSP00000358715
resolver
enst
ENST00000369701
resolver
genesymbol
SORCS3
resolver
genesymbol_syn
KIAA1059
resolver
hgnc
HGNC:16699
resolver
uniprot
Q5VXF9
resolver
uniprot
Q86XB2
resolver
uniprot
Q9NQJ2
resolver
uniprot_entry
Q86XB2_HUMAN
resolver
uniprot_entry
SORC3_HUMAN
resolver
uniprot_sec
Q5VXF9
resolver
uniprot_sec
Q9NQJ2
resolver
amino_acid_sequence
MEAARTERPAGRPGAPLVRTGLLLLSTWVLAGAEITWDATGGPGRPAAPASRPPALSPLSPRAVASQWPEELASARRAAVLGRRAGPELLPQQGGGRGGEMQVEAGGTSPAGERRGRGIPAPAKLGGARRSRRAQPPITQERGDAWATAPADGSRGSRPLAKGSREEVKAPRAGGSAAEDLRLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLYDFNLGSVTESSLWRSTDYGTTYEKLNDKVGLKTVLSYLYVNPTNKRKIMLLSDPEMESSILISSDEGATYQKYRLTFYIQSLLFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNRFYWSVAGLDKEADLVHMEVRTTDGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQDEYIFIQVTTSGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAVQEWNQNDTYNLYISDTRGIYFTLAMENIKSSRGLMGNIIIELYEVAGIKGIFLANKKVDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHLHLQLSENPYSSGRISSKETAPGLVVATGNIGPELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHSWDKYGFTSVPLFVDGALVEAGMETHIMTVFGHFSLRSEWQLVKVDYKSIFSRHCTKEDYQTWHLLNQGEPCVMGERKIFKKRKPGAQCALGRDHSGSVVSEPCVCANWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQSYLNSTGYRRIVSNNCTDGLREKYTAKAQMCPGKAPRGLHVVTTDGRLVAEQGHNATFIILMEEGDLQRTNIQLDFGDGIAVSYANFSPIEDGIKHVYKSAGIFQVTAYAENNLGSDTAVLFLHVVCPVEHVHLRVPFVAIRNKEVNISAVVWPSQLGTLTYFWWFGNSTKPLITLDSSISFTFLAEGTDTITVQVAAGNALIQDTKEIAVHEYFQSQLLSFSPNLDYHNPDIPEWRKDIGNVIKRALVKVTSVPEDQILIAVFPGLPTSAELFILPPKNLTERRKGNEGDLEQIVETLFNALNQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRKIPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFTEPEELLDKELDTRVIGGIATIANSESTKEIPNCTSV
uniprot
proteins
function
FUNCTION: Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localization ofAMPA-type glutamate receptors in the postsynaptic density. {ECO:0000250|UniProtKB:Q8VI51}.
uniprot
proteins
mass_dalton
135755
uniprot
proteins
protein_family
SORCS subfamily
uniprot
proteins
protein_family
VPS10-related sortilin family
uniprot
proteins
pubmed
10470851
uniprot
proteins
pubmed
11499680
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15710408
uniprot
proteins
pubmed
35940132
uniprot
proteins
sequence_length
1222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15710408}; Single-pass type I membrane protein {ECO:0000255}. Synaptic cell membrane {ECO:0000250|UniProtKB:Q8VI51}; Single-pass type I membrane protein {ECO:0000255}. Postsynaptic density {ECO:0000250|UniProtKB:Q8VI51}.
uniprot
proteins
transmembrane_region
TRANSMEM 1126..1146; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins