Clca2
entrez
229933
canonical
uniprot
Q8BG22
canonical
ensembl
ENSMUSG00000036960
resolver
ensp
ENSMUSP00000036029
resolver
ensp
ENSMUSP00000143161
resolver
genesymbol
Clca2
resolver
genesymbol_syn
Clca5
resolver
uniprot
Q8BZF7
resolver
uniprot_entry
CLCA2_MOUSE
resolver
uniprot_sec
Q8BZF7
resolver
amino_acid_sequence
MTHRDSTGPVIGLKLVTLLFTLSPELLFLGAGLKLKENGYDGLLVAINPRVPEDLKLITNIKEMITEASFYLFNATKRRVFFRNVQILVPATWTDHNYSRVRQESYDKANVIVAEQSEEHGDDPYTLQHRGCGQEGRYIHFTPSFLLNDELAAGYGARGRVFVHEWAHLRWGVFDEYNNDKPFYVNGRNEIQVTRCSSDITGVFVCEKGLCPHEDCIISKIFREGCTFLYNSTQNATGSIMFMPSLPSVVEFCNESTHNQEAPNLQNQVCSLRSTWDVITASSDLNHSLPVHGVGLPAPPTFSLLQAGDRVVCLVIDVSRKMAEGDRLLRLQQAAELYLMQVVEAHTFVGIVTFDSKGEIRASLQQIYSDDDRKLLVSYLPTAVSTDAETNICAGVKKGFEVVEERNGRADGSVLILVTSGADEHIANCLLTSMNSGSTIHSMALGSSAARKVGELSRLTGGLKFFIPDKFTSNGMTEAFVRISSGTGDIFQQSLQVESVCETVQPQHQLADTMTVDSAVGNDTLFLVTWQTGGPPEIALLDPSGRKYNTGDFIINLAFRTASLKIPGTAKHGHWTYTLNNTHHSPQALKVTVASRASSLAMSPATLEAFVERDSTYFPQPVIIYANVRKGLHPILNATVVATVEPEAGDPVVLQLLDGGAGADVIRNDGIYSRYFSSFAVSGSYSLTVHVRHSPSTSTLALPVPGNHAMYVPGYITNDNIQMNAPKNLGHRPVKERWGFSRVSSGGSFSVLGVPDGPHPDMFPPCKITDLEAMKVEDDVVLSWTAPGEDFDQGQTTSYEIRMSRSLWNIRDDFDNAILVNSSELVPQHAGTRETFTFSPKLVTHELDHELAEDAQEPYIVYVALRAMDRSSLRSAVSNIALVSMSLPPNSSPVVSRDDLILKGVLTTVGLIAILCLIMVVAHCIFNRKKRPSRKENETKFL
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. {ECO:0000269|PubMed:15284223, ECO:0000269|PubMed:15292178}.
uniprot
proteins
mass_dalton
103626
uniprot
proteins
post_translational_modification
PTM: The translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a N-terminal and a C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. {ECO:0000250|UniProtKB:A8K7I4}.; PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
CLCR family
uniprot
proteins
pubmed
15284223
uniprot
proteins
pubmed
15292178
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
942
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15284223}; Single-pass type I membrane protein {ECO:0000269|PubMed:15284223}. Basal cell membrane {ECO:0000269|PubMed:15284223}; Single-pass type I membrane protein {ECO:0000269|PubMed:15284223}. Cell junction {ECO:0000269|PubMed:15284223}.
uniprot
proteins
transmembrane_region
TRANSMEM 906..926; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins