Gbp7
entrez
229900
canonical
uniprot
Q91Z40
canonical
ensembl
ENSMUSG00000040253
resolver
ensp
ENSMUSP00000049104
resolver
ensp
ENSMUSP00000132970
resolver
enst
ENSMUST00000045097
resolver
enst
ENSMUST00000171263
resolver
genesymbol
Gbp7
resolver
genesymbol_syn
Gbp4l
resolver
uniprot
Q6KAN1
resolver
uniprot
Q78UK8
resolver
uniprot
Q8BU48
resolver
uniprot_entry
GBP7_MOUSE
resolver
uniprot_sec
Q6KAN1
resolver
uniprot_sec
Q78UK8
resolver
uniprot_sec
Q8BU48
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by orthovanadate, berylium fluoride and aluminum flouride. {ECO:0000269|PubMed:31689351}.
uniprot
proteins
amino_acid_sequence
MASGPNMEAPVCLVENENEELRVNSKAINILERITQPVVVVAIVGLYRTGKSYLMNRLAGQNHGFNLGTTVRSETKGIWMWCVPHPSKPKFTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLSSTFVYNSMSTINHQALEQLHYVTELTERIRAKSTSRSEEVDDSDEFVSFFPDFIWTVRDFVLELKLEGRVITADEYLENALKLIPGMSIKAQKANLPRECIRHFFPRRKCFVFDRPTKDKELLVHVEEMPEDQLDHSFQVQSKEFCSYIFSNSKAKTLKEGIVVNGNRLATLVTTYVDAINSGDVPCLENAVTTLAQRENSIAVQKAADHYSEQMAQRMRLPTDTLQELLTVHTACEKEAIAVFMEHSFKDENQQFQKNLVVTIEEKKEDFLRQNEAASLSHCQAELDKLSESLRESISRGVFSVPGGHRLYLEARKKVEQDYERVPRKGVKANHVLQSFLQSQISIEDSIMQSDKALTDGQKAMEAERAQKEAAEKEQELLRQKQKELQQVMEAQERSYKENVAQLHEKMETERKNILREQEVKLEHKLKIQKDMLNEGFKRKCEAMDLEISQLQKEIQLNKEKNSSLGAKILDGFGDVLISVVPGSGKYFGLGLKILSSQMNQTQNSDKVRKL
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:18025219, PubMed:21551061, PubMed:24739961, PubMed:31964735). Hydrolyzes GTP to GMP in two consecutive cleavage reactions and predominantly uses GTP and not GDP or GMP as the substrate (PubMed:21551061, PubMed:31689351). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (PubMed:24739961). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (PubMed:24739961). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis, such as Gm12250/Irgb10: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:24739961). Also promotes IFN-gamma-mediated host defense against bacterial infections by regulating oxidative responses and bacteriolytic peptide generation (PubMed:21551061). May help to assemble NADPH oxidase on phagosomal membranes by acting as a bridging protein between NADPH oxidase cytosolic subunits NCF2-NCF4 and the membrane subunits CYBA-CYBB (PubMed:21551061). Participates along with GBP1 in trafficking monoubiquitinated protein cargo to autolysosomes for generating ubiquitin-derived antimicrobial peptides (PubMed:21551061). Facilitates influenza A virus replication by inhibiting the activation of NF-kappaB and JAK-STAT signaling pathways and the expression of type I, type III interferons and pro-inflammatory cytokines (By similarity). Confers protection to several pathogens, including the bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (PubMed:18025219, PubMed:21551061, PubMed:31964735). Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite (PubMed:31964735). {ECO:0000250|UniProtKB:Q8N8V2, ECO:0000269|PubMed:18025219, ECO:0000269|PubMed:21551061, ECO:0000269|PubMed:24739961, ECO:0000269|PubMed:31689351, ECO:0000269|PubMed:31964735}.
uniprot
proteins
mass_dalton
72721
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="R->P: Loss of localization to cytoplasmic vesicle."; /evidence="ECO:0000269|PubMed:21551061"; MUTAGEN 51; /note="K->A: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:31689351"; MUTAGEN 52; /note="S->N: Loss of catalytic activity and localization to cytoplasmic vesicle."; /evidence="ECO:0000269|PubMed:21551061
uniprot
proteins
protein_family
GB1 subfamily
uniprot
proteins
protein_family
GB1/RHD3 GTPase family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
15449545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18025219
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21551061
uniprot
proteins
pubmed
24739961
uniprot
proteins
pubmed
31689351
uniprot
proteins
pubmed
31964735
uniprot
proteins
pubmed
33408175
uniprot
proteins
sequence_length
638
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18025219, ECO:0000269|PubMed:21551061, ECO:0000269|PubMed:31689351, ECO:0000269|PubMed:31964735}.
uniprot
proteins