CD3D
entrez
915
canonical
uniprot
P04234
canonical
ensembl
ENSG00000167286
resolver
ensp
ENSP00000300692
resolver
ensp
ENSP00000376622
resolver
genesymbol
CD3D
resolver
genesymbol_syn
T3D
resolver
hgnc
HGNC:1673
resolver
uniprot
A8MVP6
resolver
uniprot
B0YIY4
resolver
uniprot_entry
B0YIY4_HUMAN
resolver
uniprot_entry
CD3D_HUMAN
resolver
uniprot_sec
A8MVP6
resolver
amino_acid_sequence
MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELDPATVAGIIVTDVIATLLLALGVFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 19, severe combined (IMD19) [MIM:615617]: An autosomal recessive form of severe combined immunodeficiency characterized by onset in early infancy of recurrent bacterial, viral, and fungal infections. Patients usually have chronic diarrhea, recurrent respiratory infections, and failure to thrive. Immunologic work-up shows a T-cell negative, B-cell positive, NK-cell positive phenotype. {ECO:0000269|PubMed:14602880, ECO:0000269|PubMed:15546002, ECO:0000269|PubMed:21883749}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells (PubMed:12215456). {ECO:0000269|PubMed:12215456, ECO:0000269|PubMed:12507424, ECO:0000269|PubMed:2470098}.
uniprot
proteins
mass_dalton
18930
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. {ECO:0000269|PubMed:2470098}.
uniprot
proteins
pubmed
12215456
uniprot
proteins
pubmed
12507424
uniprot
proteins
pubmed
12522270
uniprot
proteins
pubmed
1372642
uniprot
proteins
pubmed
1396954
uniprot
proteins
pubmed
14602880
uniprot
proteins
pubmed
15028279
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15534202
uniprot
proteins
pubmed
15546002
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
1828760
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21883749
uniprot
proteins
pubmed
2470098
uniprot
proteins
pubmed
2540970
uniprot
proteins
pubmed
2939461
uniprot
proteins
pubmed
3488209
uniprot
proteins
pubmed
6095101
uniprot
proteins
sequence_length
171
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 106..126; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins