Klre1
entrez
243655
canonical
uniprot
Q8CJC7
canonical
ensembl
ENSMUSG00000050241
resolver
ensp
ENSMUSP00000055779
resolver
ensp
ENSMUSP00000359559
resolver
ensp
ENSMUSP00000359560
resolver
ensp
ENSMUSP00000359561
resolver
ensp
ENSMUSP00000359562
resolver
enst
ENSMUST00000053708
resolver
genesymbol
Klre1
resolver
genesymbol_syn
NKG2I
resolver
uniprot
Q80WP0
resolver
uniprot_entry
KLRE1_MOUSE
resolver
uniprot_sec
Q80WP0
resolver
amino_acid_sequence
MDEAPVTRSTLNVNSQQKSKAKNKIKNTLNSNELSSIEQRKKYQKHLKKHKNTAEDISGKGNCSPPWRLLSSVLGAMCLLLMAVAMVMTTFTTKSSSERSSSTIQQEGLHHPCPENWVWFRCSCYFFSKEELIWRDSQRACLSLNSSLIRMNKEEMNFFSLKSFFWVGVYYNETRRQWLWEDHSVLPSGLFSKLEANMKNFCASYKSKEAYMEENCANKLTYICKK
uniprot
proteins
function
FUNCTION: Lectin-like receptor for natural killer (NK) cells (PubMed:14707119, PubMed:15069013, PubMed:18713988). Can either inhibit or activate NK cell cytotoxic activity, depending on its binding partner (PubMed:14707119, PubMed:15069013, PubMed:18713988). Heterodimer formation with KLRI1 mediates NK cell inhibition whereas heterodimer formation with KLRI2 mediates NK cell activation (PubMed:18713988). Plays a role in allogeneic recognition by the immune system (PubMed:14707119, PubMed:15069013). {ECO:0000269|PubMed:14707119, ECO:0000269|PubMed:15069013, ECO:0000269|PubMed:18713988}.
uniprot
proteins
mass_dalton
26265
uniprot
proteins
pubmed
12715246
uniprot
proteins
pubmed
12782717
uniprot
proteins
pubmed
14707119
uniprot
proteins
pubmed
15069013
uniprot
proteins
pubmed
18713988
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12782717, ECO:0000269|PubMed:14707119, ECO:0000269|PubMed:15069013, ECO:0000269|PubMed:18713988}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 69..89; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins