Peds1
entrez
407243
canonical
uniprot
Q99LQ7
canonical
ensembl
ENSMUSG00000090213
resolver
ensp
ENSMUSP00000006587
resolver
enst
ENSMUST00000006587
resolver
genesymbol
Peds1
resolver
genesymbol_syn
Peds
resolver
genesymbol_syn
Tmem189
resolver
uniprot_entry
PEDS1_MOUSE
resolver
amino_acid_sequence
MAGAEDAPGRQPELDEDETAEGRRWGAQHAGARELAALYSPGKRFQEWCSVILCFSLIAHNLVHLLLLARWEHTPLVILGVVAGALVADFLSGLVHWGADTWGSVDLPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTQSPETLEQLYPWECFVFCLTIFGTFTNQIHKWSHTYLGLPYWVTVLQDWHVILPRKHHRIHHVAPHETYFCITTGWLNYPLEVIGFWRRLEDLIQGLTGEKPRADDMKWAQKIK
uniprot
proteins
ec_number
1.14.19.77
uniprot
proteins
function
FUNCTION: Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane. Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms. {ECO:0000269|PubMed:32209662}.
uniprot
proteins
mass_dalton
31134
uniprot
proteins
mutagenesis
MUTAGEN 96; /note="H->A: Loss of plasmanylethanolamine desaturase activity. Does not affect endoplasmic reticulum membrane localization."; /evidence="ECO:0000269|PubMed:32209662"; MUTAGEN 121; /note="H->A: Loss of plasmanylethanolamine desaturase activity. Does not affect endoplasmic reticulum membrane localization."; /evidence="ECO:0000269|PubMed:32209662"; MUTAGEN 122; /note="H->A: Loss of plasmanylethanolamine desaturase activity. Does not affect endoplasmic reticulum membrane localization."; /evidence="ECO:0000269|PubMed:32209662"; MUTAGEN 131; /note="H->A: Strongly reduces plasmanylethanolamine desaturase activity. Does not affect endoplasmic reticulum membrane localization."; /evidence="ECO:0000269|PubMed:32209662"; MUTAGEN 187; /note="H->A: Loss of plasmanylethanolamine desaturase activity. Does not affect endoplasmic reticulum membrane localization."; /evidence="ECO:0000269|PubMed:32209662"; MUTAGEN 191; /note="H->A: Loss of plasmanylethanolamine desaturase activity. Does not affect endoplasmic reticulum membrane localization."; /evidence="ECO:0000269|PubMed:32209662"; MUTAGEN 215; /note="H->A: Loss of plasmanylethanolamine desaturase activity. Does not affect endoplasmic reticulum membrane localization."; /evidence="ECO:0000269|PubMed:32209662"; MUTAGEN 218; /note="H->A: Loss of plasmanylethanolamine desaturase activity. Does not affect endoplasmic reticulum membrane localization."; /evidence="ECO:0000269|PubMed:32209662"; MUTAGEN 219; /note="H->A: Loss of plasmanylethanolamine desaturase activity. Does not affect endoplasmic reticulum membrane localization."; /evidence="ECO:0000269|PubMed:32209662
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000269|PubMed:32209662}.
uniprot
proteins
protein_family
Fatty acid desaturase CarF family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32209662
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:32209662}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..68; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 75..95; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 166..186; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins