Afg2a
entrez
57815
canonical
uniprot
Q3UMC0
canonical
ensembl
ENSMUSG00000027722
resolver
ensp
ENSMUSP00000029277
resolver
ensp
ENSMUSP00000103747
resolver
ensp
ENSMUSP00000143349
resolver
ensp
ENSMUSP00000200623
resolver
ensp
ENSMUSP00000200635
resolver
enst
ENSMUST00000029277
resolver
enst
ENSMUST00000108112
resolver
enst
ENSMUST00000198968
resolver
genesymbol
Afg2a
resolver
genesymbol_syn
Spaf
resolver
genesymbol_syn
Spata5
resolver
uniprot
A0A0A0MQ80
resolver
uniprot
A0A0G2JFY0
resolver
uniprot
A2ACU2
resolver
uniprot
A3KG23
resolver
uniprot
A3KG24
resolver
uniprot
Q9CXZ7
resolver
uniprot
Q9Z2K7
resolver
uniprot_entry
A0A0A0MQ80_MOUSE
resolver
uniprot_entry
A0A0G2JFY0_MOUSE
resolver
uniprot_entry
AFG2A_MOUSE
resolver
uniprot_sec
A2ACU2
resolver
uniprot_sec
A3KG23
resolver
uniprot_sec
A3KG24
resolver
uniprot_sec
Q9CXZ7
resolver
uniprot_sec
Q9Z2K7
resolver
activity_regulation
ACTIVITY REGULATION: AFG2A alone display limited ATPase activity and is not regulated by RNA or DNA binding. In the context of 55LCC heterohexameric ATPase complex, the ATPase activity increases and is stimulated by DNA binding and inhibited in presence of RNA. {ECO:0000250|UniProtKB:Q8NB90}.
uniprot
proteins
amino_acid_sequence
MSSKKNRKRQKEGAEGASPSLSAAPSRSGTSTPFAQPSPAAPGMLVVTNFLEKVDGKVPKTFQNSLVHLGLNTMKSANICIGRPVLLTSLDGKQEVYTAWPVAGFPGGKVGLSEMAQKNVGVRAGETIQVQPLLGAVLQAQEMDLALSDKDKEINEEELTGCILRKLDGKIVLPGNFLYCTFYGRLCKLQVLQVKGTDGTTLGKLQSASGTDAQGMASEHSSMESSDVDLSFQLSQLDLKEPQSPSSQSTPCKPTNDRTVNKAGEVLLDVTQSPRDGSGLGLEESTGLKCSFDSSKEGNTQPVSEEKLLKPASAGTKSNTDTFYFISSTTRINLRKICTNSKEQDSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEGRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPHLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRRVLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPSAMREVAIDVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAEIIAVCKEAALLALEENIKADCIMKRHFTQALSIVTPRIPESLRRFYEDYQEKSGLHTV
uniprot
proteins
ec_number
3.6.4.10
uniprot
proteins
function
FUNCTION: ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (By similarity). May be involved in morphological and functional mitochondrial transformations during spermatogenesis (PubMed:10734318). {ECO:0000250|UniProtKB:Q8NB90, ECO:0000269|PubMed:10734318}.
uniprot
proteins
mass_dalton
97256
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
protein_family
AFG2 subfamily
uniprot
proteins
pubmed
10734318
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
893
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10734318}. Mitochondrion {ECO:0000269|PubMed:10734318}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8NB90}.
uniprot
proteins