TMEM30A
entrez
55754
canonical
uniprot
Q9NV96
canonical
ensembl
ENSG00000112697
resolver
ensp
ENSP00000230461
resolver
ensp
ENSP00000431007
resolver
genesymbol
TMEM30A
resolver
genesymbol_syn
C6orf67
resolver
genesymbol_syn
CDC50A
resolver
hgnc
HGNC:16667
resolver
uniprot
A8K9V8
resolver
uniprot
E1P539
resolver
uniprot
Q658Z3
resolver
uniprot
Q96H09
resolver
uniprot
Q9NSL9
resolver
uniprot_entry
CC50A_HUMAN
resolver
uniprot_sec
A8K9V8
resolver
uniprot_sec
E1P539
resolver
uniprot_sec
Q658Z3
resolver
uniprot_sec
Q96H09
resolver
uniprot_sec
Q9NSL9
resolver
amino_acid_sequence
MAMNYNAKDEVDGGPPCAPGGTAKTRRPDNTAFKQQRLPAWQPILTAGTVLPIFFIIGLIFIPIGIGIFVTSNNIREIEIDYTGTEPSSPCNKCLSPDVTPCFCTINFTLEKSFEGNVFMYYGLSNFYQNHRRYVKSRDDSQLNGDSSALLNPSKECEPYRRNEDKPIAPCGAIANSMFNDTLELFLIGNDSYPIPIALKKKGIAWWTDKNVKFRNPPGGDNLEERFKGTTKPVNWLKPVYMLDSDPDNNGFINEDFIVWMRTAALPTFRKLYRLIERKSDLHPTLPAGRYSLNVTYNYPVHYFDGRKRMILSTISWMGGKNPFLGIAYIAVGSISFLLGVVLLVINHKYRNSSNTADITI
uniprot
proteins
function
FUNCTION: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:CDC50A flippase complex. ATP8A2:CDC50A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:CDC50A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediates the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations. {ECO:0000269|PubMed:20510206, ECO:0000269|PubMed:20947505, ECO:0000269|PubMed:20961850, ECO:0000269|PubMed:21289302, ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:29799007, ECO:0000269|PubMed:32493773}.
uniprot
proteins
mass_dalton
40684
uniprot
proteins
mutagenesis
MUTAGEN 132; /note="R->A: Decreases PS- and PE-dependent ATPase activity of ATP11C:CDC50A; when associated with A-133 and A-136."; /evidence="ECO:0000269|PubMed:32493773"; MUTAGEN 133; /note="R->A: Decreases PS- and PE-dependent ATPase activity of ATP11C:CDC50A; when associated with A-132 and A-136."; /evidence="ECO:0000269|PubMed:32493773"; MUTAGEN 136; /note="K->A: Decreases PS- and PE-dependent ATPase activity of ATP11C:CDC50A; when associated with A-132 and A-133."; /evidence="ECO:0000269|PubMed:32493773
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Contains high mannose-type oligosaccharides (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
CDC50/LEM3 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15375526
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20510206
uniprot
proteins
pubmed
20947505
uniprot
proteins
pubmed
20961850
uniprot
proteins
pubmed
21289302
uniprot
proteins
pubmed
21454556
uniprot
proteins
pubmed
21914794
uniprot
proteins
pubmed
25947375
uniprot
proteins
pubmed
29799007
uniprot
proteins
pubmed
31416931
uniprot
proteins
pubmed
32493773
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}. Apical cell membrane {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 50..70; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 326..346; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins