Irf4
entrez
16364
canonical
uniprot
Q64287
canonical
ensembl
ENSMUSG00000021356
resolver
ensp
ENSMUSP00000021784
resolver
ensp
ENSMUSP00000105936
resolver
genesymbol
Irf4
resolver
genesymbol_syn
Spip
resolver
uniprot
Q5SUZ4
resolver
uniprot
Q5SUZ5
resolver
uniprot
Q60802
resolver
uniprot_entry
IRF4_MOUSE
resolver
uniprot_entry
Q5SUZ4_MOUSE
resolver
uniprot_entry
Q5SUZ5_MOUSE
resolver
uniprot_sec
Q60802
resolver
amino_acid_sequence
MNLETGSRGSEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSVFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLDDTQMAMGHPYPMTAPYGSLPAQQVHNYMMPPHDRSWRDYAPDQSHPEIPYQCPVTFGPRGHHWQGPSCENGCQVTGTFYACAPPESQAPGIPIEPSIRSAEALALSDCRLHICLYYRDILVKELTTTSPEGCRISHGHTYDVSNLDQVLFPYPDDNGQRKNIEKLLSHLERGLVLWMAPDGLYAKRLCQSRIYWDGPLALCSDRPNKLERDQTCKLFDTQQFLSELQVFAHHGRPAPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQNTGHFLRGYELPEHVTTPDYHRSLRHSSIQE
uniprot
proteins
function
FUNCTION: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes. {ECO:0000269|PubMed:22983707, ECO:0000269|PubMed:22992523, ECO:0000269|PubMed:22992524}.
uniprot
proteins
mass_dalton
51577
uniprot
proteins
mutagenesis
MUTAGEN 95; /note="T->R: Mice show a severe defect in antibody production both at the steady state and after immunization with different types of antigens."; /evidence="ECO:0000269|PubMed:36662884
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by ROCK2 regulates IL-17 and IL-21 production. {ECO:0000269|PubMed:20697158}.
uniprot
proteins
protein_family
IRF family
uniprot
proteins
pubmed
20697158
uniprot
proteins
pubmed
22983707
uniprot
proteins
pubmed
22992523
uniprot
proteins
pubmed
22992524
uniprot
proteins
pubmed
26098997
uniprot
proteins
pubmed
36662884
uniprot
proteins
pubmed
7541907
uniprot
proteins
pubmed
7797077
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15306}. Cytoplasm {ECO:0000250|UniProtKB:Q15306}.
uniprot
proteins