OR5V1
entrez
81696
canonical
uniprot
Q9UGF6
canonical
ensembl
ENSG00000112461
resolver
ensembl
ENSG00000227137
resolver
ensembl
ENSG00000233046
resolver
ensembl
ENSG00000243441
resolver
ensembl
ENSG00000243729
resolver
ensp
ENSP00000230223
resolver
ensp
ENSP00000366359
resolver
ensp
ENSP00000383534
resolver
ensp
ENSP00000404109
resolver
ensp
ENSP00000404163
resolver
ensp
ENSP00000404990
resolver
ensp
ENSP00000407363
resolver
ensp
ENSP00000412591
resolver
ensp
ENSP00000415545
resolver
ensp
ENSP00000446579
resolver
ensp
ENSP00000449041
resolver
ensp
ENSP00000450230
resolver
ensp
ENSP00000493269
resolver
enst
ENST00000230223
resolver
enst
ENST00000377154
resolver
enst
ENST00000400698
resolver
enst
ENST00000418692
resolver
enst
ENST00000421859
resolver
enst
ENST00000441440
resolver
enst
ENST00000444009
resolver
enst
ENST00000446761
resolver
enst
ENST00000458372
resolver
enst
ENST00000548546
resolver
enst
ENST00000549299
resolver
enst
ENST00000550240
resolver
enst
ENST00000641768
resolver
genesymbol
OR5V1
resolver
hgnc
HGNC:13972
resolver
uniprot
A2BDZ0
resolver
uniprot
B0S860
resolver
uniprot
Q5SQI9
resolver
uniprot
Q6NTB5
resolver
uniprot
Q8IVL3
resolver
uniprot_entry
OR5V1_HUMAN
resolver
uniprot_sec
A2BDZ0
resolver
uniprot_sec
B0S860
resolver
uniprot_sec
Q5SQI9
resolver
uniprot_sec
Q6NTB5
resolver
uniprot_sec
Q8IVL3
resolver
amino_acid_sequence
MERKNQTAITEFIILGFSNLNELQFLLFTIFFLTYFCTLGGNILIILTTVTDPHLHTPMYYFLGNLAFIDICYTTSNVPQMMVHLLSKKKSISYVGCVVQLFAFVFFVGSECLLLAAMAYDRYIAICNPLRYSVILSKVLCNQLAASCWAAGFLNSVVHTVLTFCLPFCGNNQINYFFCDIPPLLILSCGNTSVNELALLSTGVFIGWTPFLCIVLSYICIISTILRIQSSEGRRKAFSTCASHLAIVFLFYGSAIFTYVRPISTYSLKKDRLVSVLYSVVTPMLNPIIYTLRNKDIKEAVKTIGSKWQPPISSLDSKLTY
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that acts both as an odorant receptor, and as a classical G protein-coupled receptor outside the olfactory epithelium (By similarity). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL/G(olf) or GNAS/G(s)) (By similarity). In olfactory epithelium, activation by methyl (9R,10E,12E)-9-methoxyoctadeca-10,12-dienoate, a plant odorant isolated from E.fortunei Turcz, promotes coupling to GNAL/G(olf), mediating activation of adenylate cyclase activity and increased production of cAMP, initiating a neuronal response that triggers the perception of a smell (By similarity). Beyond its role in olfaction, also acts as a regulator of glucose metabolism (By similarity). In liver, activation by oxylipin 12(S)-hydroxyeicosapentaenoate (12(S)-HEPE), initiates a signaling that enhances hepatic fatty acid oxidation via PKA-dependent activation of the transcription factor ATF2, which promotes expression of carnitine palmitoyltransferase CPT1A (By similarity). Outside of the olfactory system, in tissues lacking GNAL/G(olf), couples to GNAS/G(s), promoting activation of adenylate cyclase activity and production of cAMP (By similarity). {ECO:0000250|UniProtKB:A2RT31}.
uniprot
proteins
mass_dalton
36057
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12637542
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14983052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21248752
uniprot
proteins
sequence_length
321
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A2RT31}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A2RT31}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 55..75; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 197..217; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 272..292; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins