Dstyk
entrez
213452
canonical
uniprot
Q6XUX1
canonical
ensembl
ENSMUSG00000042046
resolver
ensp
ENSMUSP00000035358
resolver
genesymbol
Dstyk
resolver
genesymbol_syn
Ripk5
resolver
uniprot
Q3ULK4
resolver
uniprot
Q5EBN5
resolver
uniprot
Q8C7D4
resolver
uniprot
Q8C923
resolver
uniprot
Q9CTP7
resolver
uniprot_entry
DUSTY_MOUSE
resolver
uniprot_sec
Q3ULK4
resolver
uniprot_sec
Q5EBN5
resolver
uniprot_sec
Q8C7D4
resolver
uniprot_sec
Q8C923
resolver
uniprot_sec
Q9CTP7
resolver
amino_acid_sequence
MEADGQSWAGESVSGPGPGGGGMIRELCRGFSRYRRYLGRLRQNLRETQKFFRDIKCSHSHSCPSSPAGGGAAELGPAGDVAEAPLPAGQLSCISFPPMEETYLQQLVDRLPCILILGQDCNAKCQLLNLLLGVQVLPTLKLDSDESCKLRRLRFTYGTRTRVSLALPGQYELVHTLASHQDNWETIPEEDLEVQEDSEDAAHVLADLEVTMHHALLQEVDIVVAPCPSHRPSVDVLSDLANDFLPVITYALHKDELSERGEQELREVRQYFSFPMFFFKVPKLEIISSSSGRAESERSPLYGQLVDLGYLSSSHRNCVPSDQDCKAQSMLVEQSEKLKQLSTFSHQLLQNRLVDAAKALNVVHSHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAANMEFKDVIVPENGETIGTREIKSCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVNPPTITLEWKRKVAQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSVAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSIKLPEAFERCASKDHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLRSIMDRLCKCSSEQPNRGLDDST
uniprot
proteins
ec_number
2.7.12.1
uniprot
proteins
function
FUNCTION: Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. Involved in normal skeletal segmentation and spine formation, via positively regulating late-stage endosomal trafficking in notochord cells (By similarity). Required for normal spatial learning and memory, independent of normal brain development (PubMed:25400726). May be required for normal urinary tract and kidney formation (PubMed:37746849). {ECO:0000250|UniProtKB:Q4VSN1, ECO:0000250|UniProtKB:Q6XUX3, ECO:0000269|PubMed:25400726, ECO:0000269|PubMed:37746849}.
uniprot
proteins
mass_dalton
104901
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17123648
uniprot
proteins
pubmed
23862974
uniprot
proteins
pubmed
25400726
uniprot
proteins
pubmed
37746849
uniprot
proteins
sequence_length
927
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23862974}. Cell membrane {ECO:0000269|PubMed:23862974}. Apical cell membrane {ECO:0000269|PubMed:23862974}. Basolateral cell membrane {ECO:0000269|PubMed:23862974}. Cell junction {ECO:0000269|PubMed:23862974}. Note=Detected in basolateral and apical membranes of all tubular epithelia. Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane. {ECO:0000269|PubMed:23862974}.
uniprot
proteins