MGST2
entrez
4258
canonical
uniprot
Q99735
canonical
ensembl
ENSG00000085871
resolver
ensp
ENSP00000265498
resolver
ensp
ENSP00000424278
resolver
ensp
ENSP00000482639
resolver
ensp
ENSP00000569704
resolver
ensp
ENSP00000569705
resolver
ensp
ENSP00000641655
resolver
ensp
ENSP00000790594
resolver
genesymbol
MGST2
resolver
genesymbol_syn
GST2
resolver
hgnc
HGNC:7063
resolver
uniprot
D6RBB5
resolver
uniprot
Q7Z5B8
resolver
uniprot_entry
MGST2_HUMAN
resolver
uniprot_sec
D6RBB5
resolver
uniprot_sec
Q7Z5B8
resolver
activity_regulation
ACTIVITY REGULATION: Each monomer can bind on GSH molecule but only one subunit is catalytically active. {ECO:0000269|PubMed:23409838, ECO:0000269|PubMed:26066610}.
uniprot
proteins
amino_acid_sequence
MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTLLGALGIANSFLDEYLDLNIAKKLRRQF
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
ec_number
2.5.1.18
uniprot
proteins
ec_number
4.4.1.20
uniprot
proteins
function
FUNCTION: Catalyzes several different glutathione-dependent reactions (PubMed:23409838, PubMed:26066610, PubMed:26656251, PubMed:8703034, PubMed:9278457). Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubMed:23409838, PubMed:9278457). Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (PubMed:23409838, PubMed:8703034). Also catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (PubMed:23409838, PubMed:26656251). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed:26656251). {ECO:0000269|PubMed:23409838, ECO:0000269|PubMed:26066610, ECO:0000269|PubMed:26656251, ECO:0000269|PubMed:8703034, ECO:0000269|PubMed:9278457}.
uniprot
proteins
mass_dalton
16621
uniprot
proteins
protein_family
MAPEG family
uniprot
proteins
pubmed
11322876
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23409838
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26066610
uniprot
proteins
pubmed
26656251
uniprot
proteins
pubmed
8703034
uniprot
proteins
pubmed
9278457
uniprot
proteins
sequence_length
147
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:8703034}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000269|PubMed:8703034}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 59..79; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 111..131; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins