Khdc3
entrez
300826
canonical
uniprot
D3ZVV1
canonical
ensembl
ENSRNOG00000054460
resolver
ensembl
ENSRNOG00055007243
resolver
ensembl
ENSRNOG00060015883
resolver
ensembl
ENSRNOG00065016463
resolver
ensp
ENSRNOP00000088813
resolver
ensp
ENSRNOP00055009562
resolver
ensp
ENSRNOP00060021839
resolver
ensp
ENSRNOP00065021534
resolver
enst
ENSRNOT00000113238
resolver
enst
ENSRNOT00055012060
resolver
enst
ENSRNOT00060027227
resolver
enst
ENSRNOT00065027405
resolver
genesymbol
Khdc3
resolver
genesymbol_syn
Ecat1
resolver
uniprot_entry
KHDC3_RAT
resolver
amino_acid_sequence
MATLKTFRTLVQLKHKLGKAYEIVGEPRLPKWFHVEYLEDPKKMYVEPTLVEIMFGKDGEHIPHVECTLHVLIHVNVWGPEKQAEILIFGPPNFQKDVAQMLSNVAHFCRMKLMEKEALEAGVERRLMAASKATTQPTPVKVRDAATQVAPVQVRDAAIQPAPVKVRDAATQVAPVQVHEVATQPVPVQVRDAATQPVPVRVRDAATQPVPVRVRDAATQPVPVRVRDAATQPVPVRVRDAATEPVPVQVRDAATQPAPVQVRDAATQPAPVQVRDAATQPAPVQVRDAATQPAPVQVRDAATQPAPVQVRDAATQPAPVQVRDAATQPAPVQVREAATQQTPVEVADDTQLVQLKAGEAFAQHTSGKVHQDVNGQSPIEVCEGATQRHSVDASEALSQKCPEDLEGGDTETSLDDSYVIIRPSRAVWEPFVML
uniprot
proteins
function
FUNCTION: Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained state, regulating their availability for early embryonic development. Cytoplasmic lattices also tightly control ubiquitination during the oocyte-to-embryo transition by trapping E3 ubiquitin-protein ligase UHRF1 in a compact autoinhibited conformation and maintaining SCF ubiquitin ligase complexes inactive. KHDC3 ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart. Regulates homologous recombination-mediated DNA repair via recruitment of RAD51 to sites of DNA double-strand breaks, and sustainment of PARP1 activity, which in turn modulates downstream ATM or ATR activation. Activation of ATM or ATR in response to DNA double-strand breaks may be cell-type specific. Its role in DNA double-strand break repair is independent of its role in restarting stalled replication forks. Promotes neural stem cell neurogenesis and neuronal differentiation in the hippocampus. May regulate normal development of learning, memory and anxiety. Capable of binding RNA. {ECO:0000250|UniProtKB:Q9CWU5}.
uniprot
proteins
mass_dalton
47179
uniprot
proteins
protein_family
KHDC1 family
uniprot
proteins
pubmed
17913455
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9CWU5}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9CWU5}. Nucleus {ECO:0000250|UniProtKB:Q9CWU5}. Mitochondrion {ECO:0000250|UniProtKB:Q9CWU5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9CWU5}. Chromosome {ECO:0000250|UniProtKB:Q587J8}. Note=Core component of cytoplasmic lattices in oocytes (By similarity). Expressed in the subcortex of oocytes. Located throughout the cell cortex of ovulated eggs in a complex with NLRP5. After fertilization, restricted to the apical cortex and excluded from regions of cell-cell contact. Localized to centrosomes during interphase and mitosis (By similarity). Localizes to sites of DNA double-strand break repair (By similarity). {ECO:0000250|UniProtKB:Q587J8, ECO:0000250|UniProtKB:Q9CWU5}.
uniprot
proteins