Cenpw
entrez
689399
canonical
uniprot
A1L1L1
canonical
ensembl
ENSRNOG00000042944
resolver
ensp
ENSRNOP00000061737
resolver
enst
ENSRNOT00000065677
resolver
genesymbol
Cenpw
resolver
genesymbol_syn
Cug2
resolver
uniprot_entry
CENPW_RAT
resolver
amino_acid_sequence
MVLSTTVCRRIRRKAPCAFLKRTLKQKKPRLSLEKRCDLLIHLNCLLFVQKLAEESRTNACESKSGVIKKDHVQAAAKVILKKSRG
uniprot
proteins
function
FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
9803
uniprot
proteins
protein_family
CENP-W/WIP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
86
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5EE01}. Chromosome, centromere {ECO:0000250|UniProtKB:Q5EE01}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q5EE01}. Nucleus matrix {ECO:0000250|UniProtKB:Q5EE01}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q5EE01}. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis. {ECO:0000250|UniProtKB:P0DJH6}.
uniprot
proteins