COX6B2
entrez
125965
canonical
uniprot
Q6YFQ2
canonical
ensembl
ENSG00000160471
resolver
ensp
ENSP00000320672
resolver
ensp
ENSP00000467128
resolver
ensp
ENSP00000467266
resolver
ensp
ENSP00000467959
resolver
ensp
ENSP00000476768
resolver
enst
ENST00000326529
resolver
enst
ENST00000588572
resolver
enst
ENST00000589467
resolver
enst
ENST00000590900
resolver
enst
ENST00000593184
resolver
genesymbol
COX6B2
resolver
hgnc
HGNC:24380
resolver
uniprot
Q7L1R4
resolver
uniprot
Q96DL5
resolver
uniprot_entry
CX6B2_HUMAN
resolver
uniprot_sec
Q7L1R4
resolver
uniprot_sec
Q96DL5
resolver
amino_acid_sequence
MLDVEAQEPPKGKWSTPPFDPRFPSQNQIRNCYQNFLDYHRCLKTRTRRGKSTQPCEYYFRVYHSLCPISWVESWNEQIKNGIFAGKI
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:Q01519}.
uniprot
proteins
mass_dalton
10529
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:Q01519}.
uniprot
proteins
protein_family
Cytochrome c oxidase subunit 6B family
uniprot
proteins
pubmed
12874793
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15905330
uniprot
proteins
sequence_length
88
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00429}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00429}; Intermembrane side {ECO:0000250|UniProtKB:P00429}.
uniprot
proteins