TOMM40
entrez
10452
canonical
uniprot
O96008
canonical
ensembl
ENSG00000130204
resolver
ensp
ENSP00000252487
resolver
ensp
ENSP00000385184
resolver
ensp
ENSP00000410339
resolver
ensp
ENSP00000675279
resolver
genesymbol
TOMM40
resolver
genesymbol_syn
C19orf1
resolver
genesymbol_syn
PEREC1
resolver
genesymbol_syn
TOM40
resolver
hgnc
HGNC:18001
resolver
uniprot
A0A024R0P9
resolver
uniprot
Q86VW4
resolver
uniprot
Q8WY09
resolver
uniprot
Q8WY10
resolver
uniprot
Q8WY11
resolver
uniprot
Q9BR95
resolver
uniprot_entry
TOM40_HUMAN
resolver
uniprot_sec
A0A024R0P9
resolver
uniprot_sec
Q86VW4
resolver
uniprot_sec
Q8WY09
resolver
uniprot_sec
Q8WY10
resolver
uniprot_sec
Q8WY11
resolver
uniprot_sec
Q9BR95
resolver
amino_acid_sequence
MGNVLAASSPPAGPPPPPAPALVGLPPPPPSPPGFTLPPLGGSLGAGTSTSRSSERTPGAATASASGAAEDGACGCLPNPGTFEECHRKCKELFPIQMEGVKLTVNKGLSNHFQVNHTVALSTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLGPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRRPGEEGTVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSVSFGYQLDLPKANLLFKGSVDSNWIVGATLEKKLPPLPLTLALGAFLNHRKNKFQCGFGLTIG
uniprot
proteins
function
FUNCTION: Channel-forming protein that forms part of the translocase of the outer mitochondrial membrane (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (PubMed:15644312, PubMed:31206022, PubMed:40080546). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (PubMed:40080546). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria (PubMed:31206022). {ECO:0000269|PubMed:15644312, ECO:0000269|PubMed:31206022, ECO:0000269|PubMed:40080546}.
uniprot
proteins
mass_dalton
37893
uniprot
proteins
protein_family
Tom40 family
uniprot
proteins
pubmed
10520737
uniprot
proteins
pubmed
11745481
uniprot
proteins
pubmed
12198123
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15644312
uniprot
proteins
pubmed
18331822
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27554484
uniprot
proteins
pubmed
31206022
uniprot
proteins
pubmed
40080546
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:15644312, ECO:0000269|PubMed:31206022, ECO:0000269|PubMed:40080546}; Multi-pass membrane protein {ECO:0000269|PubMed:40080546}. Note=Associates with the mitochondria-associated ER membrane via interaction with BCAP31. {ECO:0000269|PubMed:31206022}.
uniprot
proteins
transmembrane_region
TRANSMEM 101..107; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 114..121; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 128..135; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 149..154; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 159..166; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 173..179; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 187..194; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 200..206; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 216..223; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 230..237; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 247..254; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 261..265; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 270..276; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 283..290; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 298..305; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 313..318; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 323..329; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 338..345; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ"; TRANSMEM 354..358; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ
uniprot
proteins