IMPACT
entrez
55364
canonical
uniprot
Q9P2X3
canonical
ensembl
ENSG00000154059
resolver
ensp
ENSP00000284202
resolver
genesymbol
IMPACT
resolver
hgnc
HGNC:20387
resolver
uniprot
A8MXG0
resolver
uniprot
Q49AM0
resolver
uniprot
Q9H2X4
resolver
uniprot_entry
IMPCT_HUMAN
resolver
uniprot_sec
A8MXG0
resolver
uniprot_sec
Q49AM0
resolver
uniprot_sec
Q9H2X4
resolver
amino_acid_sequence
MAEGDAGSDQRQNEEIEAMAAIYGEEWCVIDDCAKIFCIRISDDIDDPKWTLCLQVMLPNEYPGTAPPIYQLNAPWLKGQERADLSNSLEEIYIQNIGESILYLWVEKIRDVLIQKSQMTEPGPDVKKKTEEEDVECEDDLILACQPESSLKALDFDISETRTEVEVEELPPIDHGIPITDRRSTFQAHLAPVVCPKQVKMVLSKLYENKKIASATHNIYAYRIYCEDKQTFLQDCEDDGETAAGGRLLHLMEILNVKNVMVVVSRWYGGILLGPDRFKHINNCARNILVEKNYTNSPEESSKALGKNKKVRKDKKRNEH
uniprot
proteins
function
FUNCTION: Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. {ECO:0000250|UniProtKB:O55091}.
uniprot
proteins
mass_dalton
36476
uniprot
proteins
protein_family
IMPACT family
uniprot
proteins
pubmed
11116084
uniprot
proteins
pubmed
11244491
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27607563
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O55091}.
uniprot
proteins