TMEM39A
entrez
55254
canonical
uniprot
Q9NV64
canonical
ensembl
ENSG00000176142
resolver
ensp
ENSP00000326063
resolver
ensp
ENSP00000554917
resolver
ensp
ENSP00000594880
resolver
ensp
ENSP00000626014
resolver
ensp
ENSP00000674425
resolver
ensp
ENSP00000674427
resolver
ensp
ENSP00000731728
resolver
genesymbol
TMEM39A
resolver
genesymbol_syn
SUSR2
resolver
hgnc
HGNC:25600
resolver
uniprot
D3DN80
resolver
uniprot
Q53FN4
resolver
uniprot
Q53GI1
resolver
uniprot
Q6PKB5
resolver
uniprot_entry
TM39A_HUMAN
resolver
uniprot_sec
D3DN80
resolver
uniprot_sec
Q53FN4
resolver
uniprot_sec
Q53GI1
resolver
uniprot_sec
Q6PKB5
resolver
amino_acid_sequence
MPGGRRGPSRQQLSRSALPSLQTLVGGGCGNGTGLRNRNGSAIGLPVPPITALITPGPVRHCQIPDLPVDGSLLFEFLFFIYLLVALFIQYINIYKTVWWYPYNHPASCTSLNFHLIDYHLAAFITVMLARRLVWALISEATKAGAASMIHYMVLISARLVLLTLCGWVLCWTLVNLFRSHSVLNLLFLGYPFGVYVPLCCFHQDSRAHLLLTDYNYVVQHEAVEESASTVGGLAKSKDFLSLLLESLKEQFNNATPIPTHSCPLSPDLIRNEVECLKADFNHRIKEVLFNSLFSAYYVAFLPLCFVKSTQYYDMRWSCEHLIMVWINAFVMLTTQLLPSKYCDLLHKSAAHLGKWQKLEHGSYSNAPQHIWSENTIWPQGVLVRHSRCLYRAMGPYNVAVPSDVSHARFYFLFHRPLRLLNLLILIEGSVVFYQLYSLLRSEKWNHTLSMALILFCNYYVLFKLLRDRIVLGRAYSYPLNSYELKAN
uniprot
proteins
function
FUNCTION: Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools (PubMed:31806350). Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the phosphatidylinositide phosphatase SACM1L (PubMed:31806350). {ECO:0000269|PubMed:31806350}.; FUNCTION: (Microbial infection) Positively regulates the replication of encephalomyocarditis virus (EMCV) via autophagy-dependent pathway. {ECO:0000269|PubMed:31849860}.
uniprot
proteins
mass_dalton
55667
uniprot
proteins
protein_family
TMEM39 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
28133515
uniprot
proteins
pubmed
31806350
uniprot
proteins
pubmed
31849860
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:31806350}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 154..174; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 182..202; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 287..307; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 319..339; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 420..440; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 446..466; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins