Mfsd8
entrez
72175
canonical
uniprot
Q8BH31
canonical
ensembl
ENSMUSG00000025759
resolver
ensp
ENSMUSP00000026859
resolver
enst
ENSMUST00000026859
resolver
genesymbol
Mfsd8
resolver
uniprot
Q91VS1
resolver
uniprot
Q9CZ06
resolver
uniprot_entry
MFSD8_MOUSE
resolver
uniprot_sec
Q91VS1
resolver
uniprot_sec
Q9CZ06
resolver
amino_acid_sequence
MANLGSEAEREPLLGPGSPGSREWSEIETQEHYKSRWKSVRILYLTMFLSSVGFSIVIMSIWPYLQKIDQTADASFLGWVIASYSLGQMVASPLFGLWSNYRPRKEPLIVSISISVAANCLYAYVHVPAAHNKYYMLIARGLVGFGAGNVAVVRSYIAGATSLQERTNAMANTSTCQALGFILGPVFQTCFALIGEKGVTWDIIKLQVNMYTAPVLLAAFLGILNIILILFILREHRVDDLGRQCKSVNFQEENTDEPQIPEGSIDQVAVVATNIVFFVVLFIFAVYETILTPLTLDMYAWTQEQAVLYDGILLVAFGVEAVLVFMGVKLLSKKIGERAILLGGFVVVWVGFFILLPWGNQFPKIQWEDLHNSSTPNTTFGEIIIGLWNSSREDHSEQPTGCPIEQTWCLYTPVIHLAQFLTAAVLIGTGYPACSVMSYTLYSKVLGPKPQGIYMGWLTTSGSAARILGPVFISHVYTYLGPRWAFSLVCGIVVLTILLIGAVYKRLVAFSVRYMRIQE
uniprot
proteins
function
FUNCTION: Outward-rectifying chloride channel involved in endolysosomal chloride homeostasis, membrane fusion and function. Conducts chloride currents up to hundreds of picoamperes. Regulates lysosomal calcium content by reducing the lysosomal membrane potential, thereby activating TRPML1 channel and further release of lysosomal calcium ions. Regulates the pH in endolysosomal compartments and may contribute to progressive acidification from endosome to lysosome. Permeable to other halides such as iodide and fluoride ions. {ECO:0000250|UniProtKB:Q8NHS3, ECO:0000269|PubMed:34910516}.
uniprot
proteins
mass_dalton
57569
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
34910516
uniprot
proteins
sequence_length
519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q8NHS3}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q8NHS3}; Multi-pass membrane protein {ECO:0000255}. Note=Sorting to lysosomes involves dileucine-based motif. {ECO:0000250|UniProtKB:Q8NHS3}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..62; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 76..96; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 107..127; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 175..195; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 268..288; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 339..359; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 417..439; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 453..473; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 484..504; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins