Gnao1
entrez
50664
canonical
uniprot
P59215
canonical
ensembl
ENSRNOG00000019482
resolver
ensembl
ENSRNOG00055021570
resolver
ensembl
ENSRNOG00060015601
resolver
ensembl
ENSRNOG00065004094
resolver
ensp
ENSRNOP00000026373
resolver
ensp
ENSRNOP00000080513
resolver
enst
ENSRNOT00000116733
resolver
genesymbol
Gnao1
resolver
genesymbol_syn
Gna0
resolver
genesymbol_syn
Gnao
resolver
uniprot
A0A8I5ZT81
resolver
uniprot
P04900
resolver
uniprot
P30033
resolver
uniprot_entry
A0A8I5ZT81_RAT
resolver
uniprot_entry
GNAO_RAT
resolver
uniprot_sec
P04900
resolver
uniprot_sec
P30033
resolver
activity_regulation
ACTIVITY REGULATION: The GTPase activity is promoted by GTPAse activators, such as RGS14, RGS16 and RGS19. {ECO:0000250|UniProtKB:P18872}.
uniprot
proteins
amino_acid_sequence
MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGVEYGDKERKADSKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYPGSNTYEDAAAYIQTQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades, such as regulation of postsynaptic neurotransmitter release (PubMed:11050179). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase: GNAO1 acts by inhibiting the activity of adenylate cyclases, leading to decreased intracellular cAMP levels (By similarity). Plays a key role in postsynaptic inhibition of neurotransmitter release (PubMed:11050179). {ECO:0000250|UniProtKB:P18872, ECO:0000269|PubMed:11050179}.
uniprot
proteins
mass_dalton
40069
uniprot
proteins
post_translational_modification
PTM: Deamidation of Asn-346 converts alpha-1 to alpha-3. {ECO:0000269|PubMed:9990023}.; PTM: Histaminylated at Gln-205 residues by TGM2. {ECO:0000250|UniProtKB:P18872}.
uniprot
proteins
protein_family
G(i/o/t/z) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
pubmed
11050179
uniprot
proteins
pubmed
1901650
uniprot
proteins
pubmed
2158629
uniprot
proteins
pubmed
2820999
uniprot
proteins
pubmed
3086867
uniprot
proteins
pubmed
8484716
uniprot
proteins
pubmed
9990023
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P09471}; Peripheral membrane protein {ECO:0000250|UniProtKB:P09471}; Cytoplasmic side {ECO:0000250|UniProtKB:P09471}. Note=Associated to the cell membrane via lipid-anchor. {ECO:0000250|UniProtKB:P09471}.
uniprot
proteins