CCL5
entrez
6352
canonical
uniprot
P13501
canonical
ensembl
ENSG00000271503
resolver
ensembl
ENSG00000274233
resolver
ensp
ENSP00000474141
resolver
ensp
ENSP00000475057
resolver
ensp
ENSP00000479894
resolver
ensp
ENSP00000484921
resolver
ensp
ENSP00000499138
resolver
enst
ENST00000605140
resolver
enst
ENST00000605509
resolver
enst
ENST00000613606
resolver
enst
ENST00000618639
resolver
enst
ENST00000651122
resolver
genesymbol
CCL5
resolver
genesymbol_syn
D17S136E
resolver
genesymbol_syn
SCYA5
resolver
hgnc
HGNC:10632
resolver
uniprot
A0A494C1Q1
resolver
uniprot
O43646
resolver
uniprot
Q0QVW8
resolver
uniprot
Q4ZGJ1
resolver
uniprot
Q9NYA2
resolver
uniprot
Q9UBG2
resolver
uniprot
Q9UC99
resolver
uniprot_entry
A0A494C1Q1_HUMAN
resolver
uniprot_entry
CCL5_HUMAN
resolver
uniprot_sec
O43646
resolver
uniprot_sec
Q0QVW8
resolver
uniprot_sec
Q4ZGJ1
resolver
uniprot_sec
Q9NYA2
resolver
uniprot_sec
Q9UBG2
resolver
uniprot_sec
Q9UC99
resolver
amino_acid_sequence
MKVSAAALAVILIATALCAPASASPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNPAVVFVTRKNRQVCANPEKKWVREYINSLEMS
uniprot
proteins
function
FUNCTION: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) (PubMed:1380064, PubMed:15923218, PubMed:16791620, PubMed:8525373, PubMed:9516414). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485). {ECO:0000269|PubMed:1380064, ECO:0000269|PubMed:15923218, ECO:0000269|PubMed:16791620, ECO:0000269|PubMed:17001303, ECO:0000269|PubMed:23979485, ECO:0000269|PubMed:8525373, ECO:0000269|PubMed:9516414}.
uniprot
proteins
mass_dalton
9990
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="T->A: No effect on inhibition of activity by tick evasin-4."; /evidence="ECO:0000269|PubMed:25266725"; MUTAGEN 31; /note="T->A: Reduced inhibition of activity by tick evasin-4."; /evidence="ECO:0000269|PubMed:25266725"; MUTAGEN 46; /note="H->A: No effect on inhibition of activity by tick evasin-4."; /evidence="ECO:0000269|PubMed:25266725"; MUTAGEN 49; /note="E->A: No effect on inhibition of activity by tick evasin-4."; /evidence="ECO:0000269|PubMed:25266725"; MUTAGEN 55; /note="G->A,K: No effect on inhibition of activity by tick evasin-4."; /evidence="ECO:0000269|PubMed:25266725"; MUTAGEN 67..70; /note="RKNR->AANA: No effect on inhibition of activity by tick evasin-4."; /evidence="ECO:0000269|PubMed:25266725"; MUTAGEN 78..82; /note="KKWVR->AAWVA: No effect on inhibition of activity by tick evasin-4."; /evidence="ECO:0000269|PubMed:25266725
uniprot
proteins
post_translational_modification
PTM: N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells. {ECO:0000269|PubMed:9516414}.; PTM: N-terminal processed form RANTES(4-68) is produced by proteolytic cleavage by cathepsin CTSG. {ECO:0000269|PubMed:16963625}.; PTM: The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity. {ECO:0000269|PubMed:1380064}.
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
10213461
uniprot
proteins
pubmed
1380064
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15923218
uniprot
proteins
pubmed
16791620
uniprot
proteins
pubmed
16963625
uniprot
proteins
pubmed
17001303
uniprot
proteins
pubmed
23765988
uniprot
proteins
pubmed
23979485
uniprot
proteins
pubmed
2456327
uniprot
proteins
pubmed
25266725
uniprot
proteins
pubmed
32817341
uniprot
proteins
pubmed
7524281
uniprot
proteins
pubmed
7537088
uniprot
proteins
pubmed
7542919
uniprot
proteins
pubmed
8525373
uniprot
proteins
pubmed
9516414
uniprot
proteins
pubmed
9889151
uniprot
proteins
sequence_length
91
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins