C0HM01
uniprot
C0HM01
canonical
amino_acid_sequence
MIQQEEIRKLEEEKKQLEGEIIDFYKMKAASEALQTQLSTDTKKDKHPDPYEFLLLRKIKHPGFNEELSPC
uniprot
proteins
function
FUNCTION: Enhances binding of IGF2BP1 to N6-methyladenosine (m6A)-containing mRNAs, thereby contributing to increased mRNA stability (PubMed:32245947). Also increases the interaction of IGF2BP1 with RNA stabilizers ELAVL1/HUR, MATR3 and PABPC1, and increases the interaction of RNA stabilizers ELAVL1/HUR, MATR3 and PABPC1 with m6A-containing mRNAs (PubMed:32245947). Contributes to MYC stability by enhancing binding of IGF2BP1 to m6A-containing MYC mRNAs and increasing recruitment of RNA stabilizing proteins to m6A-containing MYC mRNAs (PubMed:32245947). {ECO:0000269|PubMed:32245947}.
uniprot
proteins
mass_dalton
8407
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="G->A: Abolishes binding to IGF2BP1 and does not increase binding of IGF2BP1 to m6A-containing RNAs or to RNA stabilizers ELAVL1/HUR, MATR3 or PABPC1."; /evidence="ECO:0000269|PubMed:32245947"; MUTAGEN 63; /note="G->A: No effect on binding to IGF2BP1."; /evidence="ECO:0000269|PubMed:32245947
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
32245947
uniprot
proteins
sequence_length
71
uniprot
proteins