Htra3
entrez
78558
canonical
uniprot
Q9D236
canonical
ensembl
ENSMUSG00000029096
resolver
ensp
ENSMUSP00000084910
resolver
ensp
ENSMUSP00000109871
resolver
ensp
ENSMUSP00000175691
resolver
genesymbol
Htra3
resolver
genesymbol_syn
Prsp
resolver
genesymbol_syn
Tasp
resolver
uniprot
B2RRV0
resolver
uniprot
Q6WLC5
resolver
uniprot
Q6YDR0
resolver
uniprot_entry
HTRA3_MOUSE
resolver
uniprot_sec
B2RRV0
resolver
uniprot_sec
Q6WLC5
resolver
uniprot_sec
Q6YDR0
resolver
amino_acid_sequence
MQARALLPATLAILATLAVLALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGRPLDSPCGDSLECVRGVCRCRWTHTVCGTDGHTYADVCALQAASRRALQVSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSSSTASGRQQLKVQLQNGDAYEATIQDIDKKSDIATIVIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQNKHVKDWKKRFIGIRMRTITPSLVEELKAANPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLNESSLLLEVRRGNDDLLFSIIPEVVM
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (PubMed:15206957). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity). {ECO:0000250|UniProtKB:P83110, ECO:0000269|PubMed:15206957}.
uniprot
proteins
mass_dalton
49149
uniprot
proteins
mutagenesis
MUTAGEN 311; /note="S->A: Abolishes protease activity. No inhibition of BMP4-mediated signaling."; /evidence="ECO:0000269|PubMed:15206957
uniprot
proteins
protein_family
Peptidase S1C family
uniprot
proteins
pubmed
12728021
uniprot
proteins
pubmed
15206957
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15951015
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P83110}. Note=Secretion increased during decidualization of endometrial stromal cells. {ECO:0000250|UniProtKB:P83110}.
uniprot
proteins