SELP
entrez
6403
canonical
uniprot
P16109
canonical
ensembl
ENSG00000174175
resolver
ensp
ENSP00000263686
resolver
ensp
ENSP00000356760
resolver
ensp
ENSP00000579656
resolver
ensp
ENSP00000579657
resolver
ensp
ENSP00000579658
resolver
ensp
ENSP00000579659
resolver
ensp
ENSP00000579660
resolver
ensp
ENSP00000579661
resolver
ensp
ENSP00000579664
resolver
ensp
ENSP00000579666
resolver
ensp
ENSP00000579667
resolver
ensp
ENSP00000579669
resolver
ensp
ENSP00000628080
resolver
ensp
ENSP00000628082
resolver
ensp
ENSP00000628088
resolver
enst
ENST00000263686
resolver
enst
ENST00000367786
resolver
enst
ENST00000909597
resolver
enst
ENST00000909599
resolver
enst
ENST00000909600
resolver
enst
ENST00000909601
resolver
enst
ENST00000909602
resolver
enst
ENST00000909605
resolver
enst
ENST00000909607
resolver
enst
ENST00000909608
resolver
enst
ENST00000958021
resolver
enst
ENST00000958023
resolver
enst
ENST00000958029
resolver
genesymbol
SELP
resolver
genesymbol_syn
GMRP
resolver
genesymbol_syn
GRMP
resolver
hgnc
HGNC:10721
resolver
uniprot
B2R785
resolver
uniprot
Q5R341
resolver
uniprot
Q5R344
resolver
uniprot
Q6NUL9
resolver
uniprot
Q8IVD1
resolver
uniprot_entry
B2R785_HUMAN
resolver
uniprot_entry
LYAM3_HUMAN
resolver
uniprot_entry
Q5R341_HUMAN
resolver
uniprot_entry
Q6NUL9_HUMAN
resolver
uniprot_sec
Q5R344
resolver
uniprot_sec
Q8IVD1
resolver
amino_acid_sequence
MANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRKYCQNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKTWTWVGTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVASTIGLIMGGTLLALLRKRFRQKDDGKCPLNPHSHLGTYGVFTNAAFDPSP
uniprot
proteins
function
FUNCTION: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3) (PubMed:37184585). {ECO:0000269|PubMed:11081633, ECO:0000269|PubMed:28011641, ECO:0000269|PubMed:37184585, ECO:0000269|PubMed:7585950}.
uniprot
proteins
mass_dalton
90820
uniprot
proteins
mutagenesis
MUTAGEN 57..58; /note="RK->EE: Loss of interaction with integrins. Reduces cell adhesion."; /evidence="ECO:0000269|PubMed:37184585"; MUTAGEN 95..96; /note="RK->EE: Enhances interaction with integrins."; /evidence="ECO:0000269|PubMed:37184585"; MUTAGEN 99; /note="K->E: Reduced interaction with integrins."; /evidence="ECO:0000269|PubMed:37184585"; MUTAGEN 107..108; /note="KK->EE: Reduced interaction with integrins."; /evidence="ECO:0000269|PubMed:37184585"; MUTAGEN 125..126; /note="KR->EE: Reduced interaction with integrins."; /evidence="ECO:0000269|PubMed:37184585"; MUTAGEN 129; /note="E->D: Impairs interaction with SELPLG. Abolishes cell rolling on glycan ligands. Disrupts interaction with glycan. Does not affect interaction with integrins."; /evidence="ECO:0000269|PubMed:28011641, ECO:0000269|PubMed:37184585
uniprot
proteins
protein_family
Selectin/LECAM family
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
11081633
uniprot
proteins
pubmed
11237770
uniprot
proteins
pubmed
14681304
uniprot
proteins
pubmed
15769472
uniprot
proteins
pubmed
16263699
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18606703
uniprot
proteins
pubmed
2466574
uniprot
proteins
pubmed
28011641
uniprot
proteins
pubmed
37184585
uniprot
proteins
pubmed
7505680
uniprot
proteins
pubmed
7559387
uniprot
proteins
pubmed
7585949
uniprot
proteins
pubmed
7585950
uniprot
proteins
pubmed
7684381
uniprot
proteins
pubmed
8901515
uniprot
proteins
pubmed
9668170
uniprot
proteins
sequence_length
830
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28011641}; Single-pass type I membrane protein {ECO:0000305|PubMed:28011641}.
uniprot
proteins
transmembrane_region
TRANSMEM 772..795; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins