Rnf39
entrez
171387
canonical
uniprot
Q920M2
canonical
genesymbol
Rnf39
resolver
genesymbol_syn
Lirf
resolver
uniprot_entry
RNF39_RAT
resolver
amino_acid_sequence
MEVPELGPGLVERLEQLATCPLCGGPFEDPVLLACEHSFCRSCLARCWGSPAAPGSEEATPSCPCCGQPCPRRSLRSNVRLAVEVRISRGLREKLAEPGARTGRRRGGRIPTMGCLDPQGEDMRKTWRRFDVPVPKSSNSEEDLPEDYPVVKNMLHRLTADLTLDPRTAHRDLLISSDYRGVSLAPPGTPVPLDSPERFDRLRAVLGAQGFASGRHCWEVETAEGACFRDSLAKDEDAGESCYAVGAAGESVTRKGLIKLCPSEAIWAVEGRGGRLWALTAPEPTLLGGARPPPQRIRVDLDWERGRVAFYDGRSLDLLFAFQAPGPLGERVFPLLCTCDPRAPLRIVPGEA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Plays an inhibitory role in anti-RNA viral innate immunity by targeting the adapter DDX3X and promoting its 'Lys-48'-linked polyubiquitination. Alternatively, enhances the cGAS-STING pathway activation by promoting 'Lys-63'-linked ubiquitination of STING1, facilitating the STING1-TBK1 complex formation and STING1 activation. {ECO:0000250|UniProtKB:Q9H2S5}.
uniprot
proteins
mass_dalton
38345
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9H2S5}.
uniprot
proteins
pubmed
10820183
uniprot
proteins
pubmed
11716498
uniprot
proteins
pubmed
15060004
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H2S5}.
uniprot
proteins