Rab31
entrez
246324
canonical
uniprot
Q6GQP4
canonical
ensembl
ENSRNOG00000042189
resolver
ensembl
ENSRNOG00055019082
resolver
ensembl
ENSRNOG00060005264
resolver
ensembl
ENSRNOG00065019337
resolver
ensp
ENSRNOP00000063486
resolver
ensp
ENSRNOP00055026364
resolver
ensp
ENSRNOP00060006600
resolver
ensp
ENSRNOP00065025964
resolver
enst
ENSRNOT00000067974
resolver
enst
ENSRNOT00055032557
resolver
enst
ENSRNOT00060008755
resolver
enst
ENSRNOT00065032534
resolver
genesymbol
Rab31
resolver
uniprot
Q9JK74
resolver
uniprot_entry
RAB31_RAT
resolver
uniprot_sec
Q9JK74
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including RIN3 and GAPVD1 which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation. {ECO:0000250|UniProtKB:Q13636}.
uniprot
proteins
amino_acid_sequence
MMAIRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQERFHSLAPMYYRGSAAAVIVYDITKQDSFHTLKKWVKELKEHGPENIVMAIAGNKCDLSDIREVPLKDAKEYAESIGALVVETSAKNAINIEELFQGISRQIPPLDPHENGNSGGIKLGNQSLQAGRRCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. {ECO:0000250, ECO:0000269|PubMed:11746448, ECO:0000269|PubMed:19795375}.
uniprot
proteins
mass_dalton
21500
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11746448
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17678623
uniprot
proteins
pubmed
19725050
uniprot
proteins
pubmed
19795375
uniprot
proteins
sequence_length
195
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000250|UniProtKB:Q13636}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q13636}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q13636}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000250|UniProtKB:Q13636}.
uniprot
proteins