TSC22D3
entrez
1831
canonical
uniprot
Q99576
canonical
ensembl
ENSG00000157514
resolver
ensp
ENSP00000314655
resolver
ensp
ENSP00000361458
resolver
ensp
ENSP00000361459
resolver
ensp
ENSP00000361466
resolver
ensp
ENSP00000361474
resolver
genesymbol
TSC22D3
resolver
genesymbol_syn
DSIPI
resolver
genesymbol_syn
GILZ
resolver
hgnc
HGNC:3051
resolver
uniprot
Q5H9S3
resolver
uniprot
Q5JRI9
resolver
uniprot
Q5JRJ2
resolver
uniprot
Q6FIH6
resolver
uniprot
Q8NAI1
resolver
uniprot
Q8WVB9
resolver
uniprot
Q9UBN5
resolver
uniprot
Q9UG13
resolver
uniprot_entry
T22D3_HUMAN
resolver
uniprot_sec
Q5H9S3
resolver
uniprot_sec
Q5JRI9
resolver
uniprot_sec
Q5JRJ2
resolver
uniprot_sec
Q6FIH6
resolver
uniprot_sec
Q8NAI1
resolver
uniprot_sec
Q8WVB9
resolver
uniprot_sec
Q9UBN5
resolver
uniprot_sec
Q9UG13
resolver
amino_acid_sequence
MNTEMYQTPMEVAVYQLHNFSISFFSSLLGGDVVSVKLDNSASGASVVAIDNKIEQAMDLVKNHLMYAVREEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSCLSPEEPAPESPQVPEAPGGSAV
uniprot
proteins
function
FUNCTION: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed:15031210). In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (PubMed:12393603). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (PubMed:11468175). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity). {ECO:0000250|UniProtKB:Q9Z2S7, ECO:0000269|PubMed:11468175, ECO:0000269|PubMed:12393603, ECO:0000269|PubMed:15031210}.; FUNCTION: [Isoform 1]: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. {ECO:0000250|UniProtKB:Q9Z2S7}.
uniprot
proteins
mass_dalton
14810
uniprot
proteins
protein_family
TSC-22/Dip/Bun family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11313722
uniprot
proteins
pubmed
11468175
uniprot
proteins
pubmed
12393603
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15031210
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26752201
uniprot
proteins
pubmed
37316325
uniprot
proteins
pubmed
8982256
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:Q9Z2S7}. Nucleus {ECO:0000250|UniProtKB:Q9Z2S7}. Note=Localization depends on differentiation status of myoblasts (By similarity). In undifferentiated myoblasts; localizes to the cytoplasm, but in differentiating myoblast; localizes to the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9Z2S7}.
uniprot
proteins