Cxcl10
entrez
15945
canonical
uniprot
P17515
canonical
ensembl
ENSMUSG00000034855
resolver
ensp
ENSMUSP00000047646
resolver
enst
ENSMUST00000038816
resolver
genesymbol
Cxcl10
resolver
genesymbol_syn
Crg2
resolver
genesymbol_syn
Ifi10
resolver
genesymbol_syn
Inp10
resolver
genesymbol_syn
Scyb10
resolver
uniprot
Q548V9
resolver
uniprot_entry
CXL10_MOUSE
resolver
uniprot_entry
Q548V9_MOUSE
resolver
amino_acid_sequence
MNPSAAVIFCLILLGLSGTQGIPLARTVRCNCIHIDDGPVRMRAIGKLEIIPASLSCPRVEIIATMKKNDEQRCLNPESKTIKNLMKAFSQKRSKRAP
uniprot
proteins
function
FUNCTION: Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity) (PubMed:28623423). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (PubMed:18624292, PubMed:19017990, PubMed:28468883). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (PubMed:15456824). {ECO:0000250|UniProtKB:P02778, ECO:0000269|PubMed:15456824, ECO:0000269|PubMed:18624292, ECO:0000269|PubMed:19017990, ECO:0000269|PubMed:28468883, ECO:0000269|PubMed:28623423}.
uniprot
proteins
mass_dalton
10789
uniprot
proteins
protein_family
Intercrine alpha (chemokine CxC) family
uniprot
proteins
pubmed
15456824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18560148
uniprot
proteins
pubmed
18624292
uniprot
proteins
pubmed
19017990
uniprot
proteins
pubmed
2118520
uniprot
proteins
pubmed
2189406
uniprot
proteins
pubmed
28468883
uniprot
proteins
pubmed
28623423
uniprot
proteins
pubmed
8145049
uniprot
proteins
pubmed
8454640
uniprot
proteins
sequence_length
98
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02778}.
uniprot
proteins