Frmd8
entrez
67457
canonical
uniprot
Q3UFK8
canonical
ensembl
ENSMUSG00000024816
resolver
ensp
ENSMUSP00000025728
resolver
ensp
ENSMUSP00000177906
resolver
ensp
ENSMUSP00000177907
resolver
enst
ENSMUST00000025728
resolver
genesymbol
Frmd8
resolver
uniprot
Q8C7U3
resolver
uniprot
Q8C7U5
resolver
uniprot
Q99KB3
resolver
uniprot
Q9CSY6
resolver
uniprot
Q9DC30
resolver
uniprot_entry
FRMD8_MOUSE
resolver
uniprot_sec
Q8C7U3
resolver
uniprot_sec
Q8C7U5
resolver
uniprot_sec
Q99KB3
resolver
uniprot_sec
Q9CSY6
resolver
uniprot_sec
Q9DC30
resolver
amino_acid_sequence
MEGAEGNAGQPGPAERSHRSSVSSVGARAADVLVYLADDTVVPLAVENLSSISAHELHRAVREVLQLPDVALEAFALWLVSPLLEVQLKPKHQPYKLGRQWPELLLRFTNASDDDVAMDEPSLQFRRNVFFPRRRELQIHDEEVLRLLYEEAKGNVLTARYPCDLEDCEVLGGLVCRVQLGPYQPGQPAACTLREKLDSFLPAHLCKRGHGLFAAFRGRGAKTGPGEQGLLNAYRQVKEVTGNNSEREATLGSHYRAYLLKCHELPFYGCAFFHGEVDKPAQGFLHRGGRKPVTVAISLEGVHVIDNREKHVLLGLRFQELSWDHTSPEEEEPVLWLEFDGDSEGTPVNKLLRIYSKQAELMSGLIEYCIELSQAAEPTLSQESASGPHEAPSPSPPPTQRPKLRRQGSVVCSRIQHLSTIDYVEDGKGIKRVKPKRTTSFFSRQLSSSQGSYTVVQPTDDSLEQS
uniprot
proteins
function
FUNCTION: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway (PubMed:29897333). By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity). {ECO:0000250|UniProtKB:Q9BZ67, ECO:0000269|PubMed:29897333}.
uniprot
proteins
mass_dalton
51828
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29897333
uniprot
proteins
pubmed
29897336
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BZ67}. Cell membrane {ECO:0000250|UniProtKB:Q9BZ67}.
uniprot
proteins