ANGPTL8
entrez
55908
canonical
uniprot
Q6UXH0
canonical
ensembl
ENSG00000130173
resolver
ensp
ENSP00000252453
resolver
enst
ENST00000252453
resolver
genesymbol
ANGPTL8
resolver
genesymbol_syn
C19orf80
resolver
genesymbol_syn
RIFL
resolver
hgnc
HGNC:24933
resolver
uniprot
Q9NQZ1
resolver
uniprot_entry
ANGL8_HUMAN
resolver
uniprot_sec
Q9NQZ1
resolver
amino_acid_sequence
MPVPALCLLWALAMVTRPASAAPMGGPELAQHEELTLLFHGTLQLGQALNGVYRTTEGRLTKARNSLGLYGRTIELLGQEVSRGRDAAQELRASLLETQMEEDILQLQAEATAEVLGEVAQAQKVLRDSVQRLEVQLRSAWLGPAYREFEVLKAHADKQSHILWALTGHVQRQRREMVAQQHRLRQIQERLHTAALPA
uniprot
proteins
disease_involvement
DISEASE: Type 1 diabetes mellitus (T1D) [MIM:222100]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000305|PubMed:24078058}. Note=The gene represented in this entry may be involved in disease pathogenesis. Increased protein levels are observed in the serum of patients. This result should however be reinvestigated in light of recent advances that suggest that this protein is not promoting pancreatic beta cell proliferation. {ECO:0000305|PubMed:24078058}.; DISEASE: Type 2 diabetes mellitus (T2D) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000305|PubMed:24852694, ECO:0000305|PubMed:24963292, ECO:0000305|PubMed:25024395, ECO:0000305|PubMed:25303484}. Note=The gene represented in this entry may be involved in disease pathogenesis. Increased protein levels are observed in the serum of patients and are associated with insulin resistance (PubMed:24852694, PubMed:24963292, PubMed:25024395, PubMed:25303484). According to another report, protein levels are decreased in the serum of patients (PubMed:25050901). Discrepancies between increased and decreased levels of proteins levels in T2D patients may be explained by the use of different kits developed on the market that either use antibodies recognizing the N-terminal or the C-terminal part of the protein (PubMed:25099942). These results should however be reinvestigated in light of recent advances that suggest that this protein is not promoting pancreatic beta cell proliferation. {ECO:0000305|PubMed:24852694, ECO:0000305|PubMed:24963292, ECO:0000305|PubMed:25024395, ECO:0000305|PubMed:25050901, ECO:0000305|PubMed:25099942, ECO:0000305|PubMed:25303484}.
uniprot
proteins
function
FUNCTION: Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity). {ECO:0000250|UniProtKB:Q8R1L8, ECO:0000269|PubMed:22569073, ECO:0000269|PubMed:22809513, ECO:0000269|PubMed:23150577}.
uniprot
proteins
mass_dalton
22105
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved at the N-terminus. {ECO:0000303|PubMed:25099942}.
uniprot
proteins
protein_family
ANGPTL8 family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15352036
uniprot
proteins
pubmed
22569073
uniprot
proteins
pubmed
22809513
uniprot
proteins
pubmed
23150577
uniprot
proteins
pubmed
23623304
uniprot
proteins
pubmed
24078058
uniprot
proteins
pubmed
24852694
uniprot
proteins
pubmed
24963292
uniprot
proteins
pubmed
25024395
uniprot
proteins
pubmed
25050901
uniprot
proteins
pubmed
25099942
uniprot
proteins
pubmed
25303484
uniprot
proteins
pubmed
25417115
uniprot
proteins
pubmed
28038792
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23150577}.
uniprot
proteins