SEMA4D
entrez
10507
canonical
uniprot
Q92854
canonical
ensembl
ENSG00000187764
resolver
ensp
ENSP00000348822
resolver
ensp
ENSP00000388768
resolver
ensp
ENSP00000391733
resolver
ensp
ENSP00000395222
resolver
ensp
ENSP00000405102
resolver
ensp
ENSP00000416523
resolver
ensp
ENSP00000446394
resolver
ensp
ENSP00000528626
resolver
ensp
ENSP00000528628
resolver
ensp
ENSP00000528629
resolver
ensp
ENSP00000528630
resolver
ensp
ENSP00000528631
resolver
ensp
ENSP00000528632
resolver
ensp
ENSP00000528633
resolver
ensp
ENSP00000528635
resolver
ensp
ENSP00000528636
resolver
ensp
ENSP00000587940
resolver
ensp
ENSP00000587941
resolver
ensp
ENSP00000587949
resolver
ensp
ENSP00000587950
resolver
ensp
ENSP00000662570
resolver
ensp
ENSP00000662572
resolver
ensp
ENSP00000662573
resolver
ensp
ENSP00000662575
resolver
ensp
ENSP00000717287
resolver
ensp
ENSP00000717290
resolver
ensp
ENSP00000717291
resolver
ensp
ENSP00000757252
resolver
enst
ENST00000429836
resolver
enst
ENST00000537934
resolver
genesymbol
SEMA4D
resolver
genesymbol_syn
C9orf164
resolver
genesymbol_syn
CD100
resolver
genesymbol_syn
SEMAJ
resolver
hgnc
HGNC:10732
resolver
uniprot
B2RPM6
resolver
uniprot
E9PFD9
resolver
uniprot
Q7Z5S4
resolver
uniprot
Q8N8B0
resolver
uniprot_entry
E9PFD9_HUMAN
resolver
uniprot_entry
SEM4D_HUMAN
resolver
uniprot_sec
B2RPM6
resolver
uniprot_sec
Q7Z5S4
resolver
uniprot_sec
Q8N8B0
resolver
amino_acid_sequence
MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKVVPKPVVAPTLSVVQTEGSRIATKVLVASTQGSSPPTPAVQATSSGAITLPPKPAPTGTSCEPKIVINTVPQLHSEKTMYLKSSDNRLLMSLFLFFFVLFLCLFFYNCYKGYLPRQCLKFRSALLIGKKKPKSDFCDREQSLKETLVEPGSFSQQNGEHPKPALDTGYETEQDTITSKVPTDREDSQRIDDLSARDKPFDVKCELKFADSDADGD
uniprot
proteins
function
FUNCTION: Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). {ECO:0000250|UniProtKB:O09126, ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}.
uniprot
proteins
mass_dalton
96150
uniprot
proteins
mutagenesis
MUTAGEN 100..101; /note="KG->DT: Abolishes PLXNB1 binding."; /evidence="ECO:0000269|PubMed:20877282"; MUTAGEN 181..182; /note="FL->ER: Abolishes PLXNB1 binding."; /evidence="ECO:0000269|PubMed:20877282"; MUTAGEN 244; /note="F->N: Abolishes homodimerization, abolishes collapse of growth cones and reduces PLXNB1 binding; when associated with S-246."; /evidence="ECO:0000269|PubMed:20877282"; MUTAGEN 246; /note="F->S: Abolishes homodimerization, abolishes collapse of growth cones and reduces PLXNB1 binding; when associated with N-244."; /evidence="ECO:0000269|PubMed:20877282"; MUTAGEN 395; /note="K->E: Strongly reduces PLXNB1 binding."; /evidence="ECO:0000269|PubMed:20877282
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Proteolytically cleaved at the cell membrane upon H.pylori infection. {ECO:0000269|PubMed:34742300}.
uniprot
proteins
protein_family
Semaphorin family
uniprot
proteins
pubmed
10520995
uniprot
proteins
pubmed
12958590
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16055703
uniprot
proteins
pubmed
16263699
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19788569
uniprot
proteins
pubmed
20877282
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
34742300
uniprot
proteins
pubmed
8876214
uniprot
proteins
sequence_length
862
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34742300}. Note=(Microbial infection) Proteolytically cleaved at the cell membrane upon H.pylori infection. {ECO:0000269|PubMed:34742300}.
uniprot
proteins
transmembrane_region
TRANSMEM 735..755; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins