Il13
entrez
16163
canonical
uniprot
P20109
canonical
ensembl
ENSMUSG00000020383
resolver
ensp
ENSMUSP00000020650
resolver
enst
ENSMUST00000020650
resolver
genesymbol
Il13
resolver
genesymbol_syn
Il-13
resolver
uniprot_entry
IL13_MOUSE
resolver
amino_acid_sequence
MALWVTAVLALACLGGLAAPGPVPRSVSLPLTLKELIEELSNITQDQTPLCNGSMVWSVDLAAGGFCVALDSLTNISNCNAIYRTQRILHGLCNRKAPTTVSSLPDTKIEVAHFITKLLSYTKQLFRHGPF
uniprot
proteins
function
FUNCTION: Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:15361238). Synergizes with IL2 in regulating interferon-gamma synthesis. Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (By similarity). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (PubMed:34789557). Displays the capacity to antagonize Th1-driven proinflammatory immune response and down-regulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Also functions on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils. Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 (PubMed:34795444, PubMed:8871614). Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (PubMed:29305434). Induces inflammatory response in esophageal epithelium which results in a dysregulation of desmosome intercellular adhesion junctions, via down-regulation of DSG1 (PubMed:24220297). {ECO:0000250|UniProtKB:P35225, ECO:0000250|UniProtKB:P42203, ECO:0000269|PubMed:15361238, ECO:0000269|PubMed:24220297, ECO:0000269|PubMed:29305434, ECO:0000269|PubMed:34789557, ECO:0000269|PubMed:34795444, ECO:0000269|PubMed:8871614}.
uniprot
proteins
mass_dalton
14108
uniprot
proteins
protein_family
IL-4/IL-13 family
uniprot
proteins
pubmed
15361238
uniprot
proteins
pubmed
24220297
uniprot
proteins
pubmed
2521353
uniprot
proteins
pubmed
25847241
uniprot
proteins
pubmed
29305434
uniprot
proteins
pubmed
34789557
uniprot
proteins
pubmed
34795444
uniprot
proteins
pubmed
8871614
uniprot
proteins
sequence_length
131
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins