Dhrs4
entrez
28200
canonical
uniprot
Q99LB2
canonical
ensembl
ENSMUSG00000022210
resolver
ensp
ENSMUSP00000022821
resolver
ensp
ENSMUSP00000154481
resolver
enst
ENSMUST00000022821
resolver
enst
ENSMUST00000226168
resolver
genesymbol
Dhrs4
resolver
genesymbol_syn
D14Ucla2
resolver
uniprot
A0A2I3BR85
resolver
uniprot
G3X8V7
resolver
uniprot
Q3UIB5
resolver
uniprot
Q9D2U3
resolver
uniprot
Q9EQU4
resolver
uniprot_entry
A0A2I3BR85_MOUSE
resolver
uniprot_entry
DHRS4_MOUSE
resolver
uniprot_entry
Q3UIB5_MOUSE
resolver
uniprot_entry
Q9D2U3_MOUSE
resolver
uniprot_sec
G3X8V7
resolver
uniprot_sec
Q9EQU4
resolver
amino_acid_sequence
MQKAGRLLGGWTQAWMSVRMASSGLTRRNPLSNKVALVTASTDGIGFAIARRLAEDGAHVVVSSRKQQNVDRAVATLQGEGLSVTGIVCHVGKAEDREKLITTALKRHQGIDILVSNAAVNPFFGNLMDVTEEVWDKVLSINVTATAMMIKAVVPEMEKRGGGSVVIVGSVAGFTRFPSLGPYNVSKTALLGLTKNFAAELAPKNIRVNCLAPGLIKTRFSSVLWEEKAREDFIKEAMQIRRLGKPEDCAGIVSFLCSEDASYINGETVVVGGGTPSRL
uniprot
proteins
ec_number
1.1.1.184
uniprot
proteins
ec_number
1.1.1.300
uniprot
proteins
function
FUNCTION: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces all-trans-retinal and 9-cis retinal. Reduces 3-ketosteroids and benzil into 3alpha-hydroxysteroids and S-benzoin, respectively, in contrast to the stereoselectivity of primates DHRS4s which produce 3beta-hydroxysteroids and R-benzoin. In the reverse reaction, catalyzes the NADP-dependent oxidation of 3alpha-hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3alpha-hydroxysteroids, retinoid, isatin and xenobiotic carbonyl compounds. {ECO:0000250|UniProtKB:Q8WNV7}.
uniprot
proteins
mass_dalton
29885
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
279
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:Q8WNV7}.
uniprot
proteins