P0DMM9
uniprot
P0DMM9
canonical
amino_acid_sequence
MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLINTYPKSGTTWVSQILDMIYQGGDLEKCNRAPIYVRVPFLEVNDPGEPSGLETLKDTPPPRLIKSHLPLALLPQTLLDQKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETMDFMVQHTSFKEMKKNPMTNYTTVPQELMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL
uniprot
proteins
ec_number
2.8.2.1
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, (R)-adrenaline/epinephrine, (R)-noradrenaline/norepinephrine and serotonin) and phenolic and catechol drugs (PubMed:8093002, PubMed:29524394, PubMed:14622112, PubMed:15358107). Catalyzes the sulfation of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine), T3 (3,5,3'-triiodothyronine), rT3 (3,3',5'-triiodothyronine) and 3,3'-T2 (3,3'-diiodothyronine), with a substrate preference of 3,3'-T2 > rT3 > T3 > T4 (PubMed:10199779). {ECO:0000269|PubMed:10199779, ECO:0000269|PubMed:14622112, ECO:0000269|PubMed:15358107, ECO:0000269|PubMed:29524394, ECO:0000269|PubMed:8093002}.
uniprot
proteins
mass_dalton
34196
uniprot
proteins
mutagenesis
MUTAGEN 235; /note="N->T: A 5-fold increase in KM and 3-fold decrease in VMAX for (R)-noradrenaline. A 100-fold increase in KM and a 3-fold increase in VMAX for serotonin. A 20-fold increase in KM for (R)-adrenaline. A 2-fold increase in KM for dopamine."; /evidence="ECO:0000269|PubMed:29524394"; MUTAGEN 290; /note="S->T: A 2-fold increase in KM for serotonin."; /evidence="ECO:0000269|PubMed:29524394
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
10199779
uniprot
proteins
pubmed
10543947
uniprot
proteins
pubmed
14622112
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15358107
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16083857
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
29524394
uniprot
proteins
pubmed
7695637
uniprot
proteins
pubmed
7695643
uniprot
proteins
pubmed
7802665
uniprot
proteins
pubmed
7829089
uniprot
proteins
pubmed
7961757
uniprot
proteins
pubmed
8093002
uniprot
proteins
pubmed
8117269
uniprot
proteins
pubmed
8187949
uniprot
proteins
pubmed
8363592
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8093002}.
uniprot
proteins