RFTN1
entrez
23180
canonical
uniprot
Q14699
canonical
ensembl
ENSG00000131378
resolver
ensp
ENSP00000334153
resolver
ensp
ENSP00000527000
resolver
ensp
ENSP00000527005
resolver
ensp
ENSP00000527006
resolver
ensp
ENSP00000726583
resolver
ensp
ENSP00000756829
resolver
enst
ENST00000334133
resolver
enst
ENST00000856941
resolver
enst
ENST00000856946
resolver
enst
ENST00000856947
resolver
genesymbol
RFTN1
resolver
genesymbol_syn
KIAA0084
resolver
hgnc
HGNC:30278
resolver
uniprot
Q0D2G0
resolver
uniprot
Q496Y2
resolver
uniprot
Q4QQI7
resolver
uniprot
Q5JB48
resolver
uniprot
Q7Z7P2
resolver
uniprot
Q8N5I0
resolver
uniprot_entry
Q8N5I0_HUMAN
resolver
uniprot_entry
RFTN1_HUMAN
resolver
uniprot_sec
Q0D2G0
resolver
uniprot_sec
Q496Y2
resolver
uniprot_sec
Q4QQI7
resolver
uniprot_sec
Q5JB48
resolver
uniprot_sec
Q7Z7P2
resolver
amino_acid_sequence
MGCGLNKLEKRDEKRPGNIYSTLKRPQVETKIDVSYEYRFLEFTTLSAAELPGSSAVRLASLRDLPAQLLELYQQGFSLAALHPFVQPTHEREKTPLEHIFRAILIKKTDRSQKTDLHNEGYILELDCCSSLDHPTDQKLIPEFIKKIQEAASQGLKFVGVIPQYHSSVNSAGSSAPVSTANSTEDARDAKNARGDHASLENEKPGTGDVCSAPAGRNQSPEPSSGPRGEVPLAKQPSSPSGEGDGGELSPQGVSKTLDGPESNPLEVHEEPLSGKMEIFTLFNKPKSHQKCRQYYPVTIPLHVSKNGQTVSGLDANWLEHMSDHFRKGGMLVNAVFYLGIVNDSLHGLTDGVFIFEAVSTEDSKTIQGYDAIVVEQWTVLEGVEVQTDYVPLLNSLAAYGWQLTCVLPTPVVKTTSEGSVSTKQIVFLQRPCLPQKIKKKESKFQWRFSREEMHNRQMRKSKGKLSARDKQQAEENEKNLEDQSSKAGDMGNCVSGQQQEGGVSEEMKGPVQEDKGEQLSPGGLLCGVGVEGEAVQNGPASHSRALVGICTGHSNPGEDARDGDAEEVRELGTVEEN
uniprot
proteins
function
FUNCTION: Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}.
uniprot
proteins
mass_dalton
63146
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Loss of association with membranes. Same effect; when associated with S-3."; /evidence="ECO:0000269|PubMed:12805216"; MUTAGEN 3; /note="C->S: Partially affects association with membranes. Loss of association with membranes; when associated with A-2."; /evidence="ECO:0000269|PubMed:12805216
uniprot
proteins
protein_family
Raftlin family
uniprot
proteins
pubmed
12805216
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20213681
uniprot
proteins
pubmed
21266579
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27022195
uniprot
proteins
pubmed
7788527
uniprot
proteins
sequence_length
578
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}; Lipid-anchor {ECO:0000269|PubMed:12805216}. Cytoplasm {ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. Membrane raft {ECO:0000269|PubMed:12805216}. Endosome {ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. Early endosome {ECO:0000269|PubMed:21266579}. Note=Translocates from cytoplasm to cell membrane where it colocalizes with poly (I:C) and then moves to endosomes where it colocalizes with TLR3 (PubMed:21266579). Translocates from cytoplasm to cell membrane where it colocalizes with TLR4 and then together with TLR4 moves to endosomes, upon lipopolysaccharide stimulation (PubMed:27022195). {ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}.
uniprot
proteins