MLLT10
entrez
8028
canonical
uniprot
P55197
canonical
ensembl
ENSG00000078403
resolver
ensp
ENSP00000307411
resolver
ensp
ENSP00000366272
resolver
ensp
ENSP00000366295
resolver
ensp
ENSP00000366304
resolver
ensp
ENSP00000408281
resolver
ensp
ENSP00000498595
resolver
ensp
ENSP00000673256
resolver
genesymbol
MLLT10
resolver
genesymbol_syn
AF10
resolver
hgnc
HGNC:16063
resolver
uniprot
B1ANA8
resolver
uniprot
Q59EQ6
resolver
uniprot
Q5JT37
resolver
uniprot
Q5VX90
resolver
uniprot
Q66K63
resolver
uniprot_entry
AF10_HUMAN
resolver
uniprot_entry
Q59EQ6_HUMAN
resolver
uniprot_sec
B1ANA8
resolver
uniprot_sec
Q5JT37
resolver
uniprot_sec
Q5VX90
resolver
uniprot_sec
Q66K63
resolver
amino_acid_sequence
MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANTLSGSSLSQAPSHMYGNRSNSSMAALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGNSSLENLPPVAASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVMQTPVTMSQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQILIHQQQFQQLLNSQQLTPEQHQAFLYQLMQHHHQQHHQPELQQLQIPGPTQIPINNLLAGTQAPPLHTATTNPFLTIHGDNASQKVARLSDKTGPVAQEKS
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein.; DISEASE: Note=A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.
uniprot
proteins
function
FUNCTION: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}.
uniprot
proteins
mass_dalton
113320
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="I->A: Does not affect interaction with histone H3."; /evidence="ECO:0000269|PubMed:26439302"; MUTAGEN 80; /note="V->A: Does not affect interaction with histone H3."; /evidence="ECO:0000269|PubMed:26439302"; MUTAGEN 106; /note="A->V: Impairs interaction with histone H3."; /evidence="ECO:0000269|PubMed:26439302"; MUTAGEN 107; /note="L->A: Impairs interaction with histone H3. Reduces association to chromatin. Does not rescued histone H3 'Lys-79' dimethylation (H3K79me2) levels in MLLT10-depleted cells. Does not rescued DOT1L-target genes in MLLT10-depleted cells."; /evidence="ECO:0000269|PubMed:26439302"; MUTAGEN 109; /note="I->A: Impairs interaction with histone H3."; /evidence="ECO:0000269|PubMed:26439302"; MUTAGEN 114; /note="F->A: Impairs interaction with histone H3."; /evidence="ECO:0000269|PubMed:26439302"; MUTAGEN 120; /note="M->A: Impairs interaction with histone H3."; /evidence="ECO:0000269|PubMed:26439302"; MUTAGEN 179; /note="E->A: Impairs interaction with histone H3."; /evidence="ECO:0000269|PubMed:26439302"; MUTAGEN 190; /note="Y->A: Impairs interaction with histone H3."; /evidence="ECO:0000269|PubMed:26439302
uniprot
proteins
pubmed
10860745
uniprot
proteins
pubmed
11423977
uniprot
proteins
pubmed
11756182
uniprot
proteins
pubmed
11986236
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15851025
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17868029
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
26439302
uniprot
proteins
pubmed
7888665
uniprot
proteins
sequence_length
1068
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10860745}.
uniprot
proteins