Dio1
entrez
13370
canonical
uniprot
Q61153
canonical
ensembl
ENSMUSG00000034785
resolver
ensp
ENSMUSP00000081007
resolver
genesymbol
Dio1
resolver
genesymbol_syn
Itdi1
resolver
genesymbol_syn
Txdi1
resolver
uniprot
Q05CY5
resolver
uniprot
Q5FW63
resolver
uniprot_entry
IOD1_MOUSE
resolver
uniprot_sec
Q05CY5
resolver
uniprot_sec
Q5FW63
resolver
amino_acid_sequence
MGLPQLWLWLKRLVIFLQVALEVAVGKVLMTLFPGRVKQSILAMGQKTGMARNPRFAPDNWVPTFFSIQYFWFVLKVRWQRLEDRAEFGGLAPNCTVVCLSGQKCNIWDFIQGSRPLVLNFGSCTUPSFLLKFDQFKRLVDDFASTADFLIIYIEEAHATDGWAFKNNVDIRQHRSLQERVRAARLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRICYKGKAGPWNYNPEEVRAVLEKLCTPPRHVPQL
uniprot
proteins
ec_number
1.21.99.3
uniprot
proteins
ec_number
1.21.99.4
uniprot
proteins
function
FUNCTION: Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:18821722, PubMed:32718224). Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) via outer-ring deiodination (ORD) (PubMed:32718224, PubMed:18339710). Catalyzes the deiodination of T4 to rT3, 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine (3-T1), T3 to 3,3'-T2 and 3,3'-T2 to 3-T1 via inner-ring deiodination (IRD) (PubMed:18821722, PubMed:32718224). Catalyzes the deiodiantion of 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via ORD (By similarity). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine, 3',5'-diiodothyronamine and 3,3'-diiodothyronamine as well as tyrosyl ring deiodinations of 3,5,3'-triiodothyronamine and 3,5-diiodothyronamine (PubMed:18339710). Catalyzes the deiodination of L-thyroxine sulfate and 3,3',5-triiodo-L-thyronine sulfate via IRD and of 3,3',5'-triiodo-L-thyronine sulfate via ORD (By similarity). {ECO:0000250|UniProtKB:P24389, ECO:0000250|UniProtKB:P49895, ECO:0000250|UniProtKB:Q2QEI3, ECO:0000269|PubMed:18339710, ECO:0000269|PubMed:18821722, ECO:0000269|PubMed:32718224}.
uniprot
proteins
mass_dalton
29568
uniprot
proteins
protein_family
Iodothyronine deiodinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18339710
uniprot
proteins
pubmed
18821722
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32718224
uniprot
proteins
pubmed
7476994
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P24389}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:P24389}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P24389}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:P24389}. Basolateral cell membrane {ECO:0000250|UniProtKB:P24389}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:P24389}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins