Brf2
entrez
306542
canonical
uniprot
Q4V8D6
canonical
ensembl
ENSRNOG00000012739
resolver
ensembl
ENSRNOG00055008130
resolver
ensembl
ENSRNOG00060011219
resolver
ensembl
ENSRNOG00065002697
resolver
ensp
ENSRNOP00000017324
resolver
ensp
ENSRNOP00055011035
resolver
ensp
ENSRNOP00060014787
resolver
ensp
ENSRNOP00065002536
resolver
enst
ENSRNOT00000017324
resolver
enst
ENSRNOT00055013744
resolver
enst
ENSRNOT00060018960
resolver
enst
ENSRNOT00065003653
resolver
genesymbol
Brf2
resolver
uniprot_entry
BRF2_RAT
resolver
amino_acid_sequence
MPNGSRCPDCGSSELVEDSHYSQSQLVCSDCGCVVTEGVLTTTFSDEGNLREVTYSRSTGENEQVSRSQQRDLRRVRDLCRILKLPLTFEETAVSYYQKAYQLSGIRAARLQKKEVVVGCCVLITCRQHNWPLTMGAICTLLYADLDVFSSTYMQIVKLLGLDVPSLCLADLVKSYCSSFKLFQASPSMPAKYVEDKDKMLSRTLLLVELANETWLVTGRHPLPIITAATFLAWQSLRPSDRLTCSLARFCKLANVDLPYPAASRLQELLAVLLQMASQLAWLQVLRLDKRSVVKHIGDLLQHRHMLVRMAFQDGTAEVETKQQQPQGRGQQEEVGDSTFDLPKRKRPASPALLLPPCMLKPPKRTHTMPPDSVVTGDEDISDSEIEQYLRTPQEVRDFERAQAASRAAMSVPNPP
uniprot
proteins
function
FUNCTION: General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress. {ECO:0000250|UniProtKB:Q9HAW0}.
uniprot
proteins
mass_dalton
46596
uniprot
proteins
post_translational_modification
PTM: In response to oxidative stress, Cys-358 is reversibly oxidized to cysteine sulfenic acid. Oxidation of Cys-358 impairs formation of a ternary complex with TBP and DNA and down-regulates expression of target genes in response to oxidative stress. {ECO:0000250|UniProtKB:Q9HAW0}.
uniprot
proteins
protein_family
TFIIB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9HAW0}.
uniprot
proteins