Gal3st3
entrez
545276
canonical
uniprot
P61315
canonical
ensembl
ENSMUSG00000047658
resolver
ensp
ENSMUSP00000061517
resolver
enst
ENSMUST00000061169
resolver
genesymbol
Gal3st3
resolver
uniprot_entry
G3ST3_MOUSE
resolver
amino_acid_sequence
MPPILQRLQQSTKMMSHRKILLLVLGCSTVSLLIHQGSQLSWYPKLFPLSCPPLRESPPRAKHMAVAFLKTHKTAGTTVQNILFRFAERHNLTVALPHPSCEHQFCYPRNFSAHFVHPATRPPHMLASHLRFDRAELERLMPPDTIYVTILREPAAMFESLFSYYNQYCPAFRRVPNASLETFLRAPEAYYRPGEHFAMFAHNTLAYDLGGDNERSPRDDAAYLAGLIRQVEEVFSLVMIAEYFDESLVLLRRLLAWDLDDVLYAKLNARAASSRLATIPEALARAARTWNALDAGLYDHFNATFWRRVARAGRACVEREARELREARQRLLRRCFGDEPVLRPAAQIRTKQLQPWQPSRKVDIMGYDLPSGGAGPTTEACLKLAMPEVQYSNYLLRKQKRRGGVRSRPESVLDNPPPRPIRALPRIPQGT
uniprot
proteins
ec_number
2.8.2.-
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a sulfate group from 3'-phosphoadenylyl sulfate (PAPS) to the C-3 hydroxyl group of terminal non-reducing beta-1,4-linked galactose residues in both N-glycans and O-glycans. It acts efficiently on type 2 chains (Gal-beta-1,4-GlcNAc-R) found in N-glycans and core 2-branched O-glycans (Gal-beta-1,4-GlcNAc-beta-1,6(Gal-beta-1,3)GalNAc-R). In contrast, it shows poor activity on type 1 chains (Gal-beta-1,3-GlcNAc-R) and intermediate activity on core 1 structures (Gal-beta-1,3-GalNAc-R). Participates in the glycoconjugates sulfation namely the 3'-sulfated Lewis X epitope (Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc), by sulfating N-acetyllactosamine (Gal-beta-1,4-GlcNAc) at the 3' position; then the resulting modification is fucosylated by FUT5. {ECO:0000250|UniProtKB:Q96A11}.
uniprot
proteins
mass_dalton
49277
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; carbohydrate sulfation. {ECO:0000250|UniProtKB:Q96A11}.
uniprot
proteins
protein_family
Galactose-3-O-sulfotransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
431
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins