ABCB5
entrez
340273
canonical
uniprot
Q2M3G0
canonical
ensembl
ENSG00000004846
resolver
ensp
ENSP00000258738
resolver
ensp
ENSP00000383899
resolver
ensp
ENSP00000384881
resolver
ensp
ENSP00000406730
resolver
genesymbol
ABCB5
resolver
hgnc
HGNC:46
resolver
uniprot
A4D131
resolver
uniprot
A7BKA4
resolver
uniprot
B5MD19
resolver
uniprot
B7WPL1
resolver
uniprot
F8QQP8
resolver
uniprot
F8QQP9
resolver
uniprot
J3KQ04
resolver
uniprot
Q2M3I5
resolver
uniprot
Q5I5Q7
resolver
uniprot
Q5I5Q8
resolver
uniprot
Q6KG50
resolver
uniprot
Q6XFQ5
resolver
uniprot
Q8IXA1
resolver
uniprot_entry
ABCB5_HUMAN
resolver
uniprot_sec
A4D131
resolver
uniprot_sec
A7BKA4
resolver
uniprot_sec
B5MD19
resolver
uniprot_sec
B7WPL1
resolver
uniprot_sec
F8QQP8
resolver
uniprot_sec
F8QQP9
resolver
uniprot_sec
J3KQ04
resolver
uniprot_sec
Q2M3I5
resolver
uniprot_sec
Q5I5Q7
resolver
uniprot_sec
Q5I5Q8
resolver
uniprot_sec
Q6KG50
resolver
uniprot_sec
Q6XFQ5
resolver
uniprot_sec
Q8IXA1
resolver
amino_acid_sequence
MENSERAEEMQENYQRNGTAEEQPKLRKEAVGSIEIFRFADGLDITLMILGILASLVNGACLPLMPLVLGEMSDNLISGCLVQTNTTNYQNCTQSQEKLNEDMTLLTLYYVGIGVAALIFGYIQISLWIITAARQTKRIRKQFFHSVLAQDIGWFDSCDIGELNTRMTDDIDKISDGIGDKIALLFQNMSTFSIGLAVGLVKGWKLTLVTLSTSPLIMASAAACSRMVISLTSKELSAYSKAGAVAEEVLSSIRTVIAFRAQEKELQRYTQNLKDAKDFGIKRTIASKVSLGAVYFFMNGTYGLAFWYGTSLILNGEPGYTIGTVLAVFFSVIHSSYCIGAAVPHFETFAIARGAAFHIFQVIDKKPSIDNFSTAGYKPESIEGTVEFKNVSFNYPSRPSIKILKGLNLRIKSGETVALVGLNGSGKSTVVQLLQRLYDPDDGFIMVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQSVQ
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
function
FUNCTION: Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:12960149, PubMed:15205344, PubMed:15899824, PubMed:22306008). Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity). {ECO:0000250|UniProtKB:B5X0E4, ECO:0000269|PubMed:12960149, ECO:0000269|PubMed:15205344, ECO:0000269|PubMed:15899824, ECO:0000269|PubMed:22306008}.
uniprot
proteins
mass_dalton
138641
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCB family
uniprot
proteins
protein_family
Multidrug resistance exporter (TC 3.A.1.201) subfamily
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
12960149
uniprot
proteins
pubmed
15205344
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15760339
uniprot
proteins
pubmed
15899824
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18772397
uniprot
proteins
pubmed
21652540
uniprot
proteins
pubmed
22044138
uniprot
proteins
pubmed
22306008
uniprot
proteins
pubmed
22675422
uniprot
proteins
pubmed
22784549
uniprot
proteins
pubmed
23770371
uniprot
proteins
pubmed
24934811
uniprot
proteins
pubmed
25030174
uniprot
proteins
sequence_length
1257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12960149}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:12960149}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 181..201; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 294..314; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 322..342; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 693..713; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 737..757; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 827..847; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 917..937; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 954..974; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins