Atp2b1
entrez
67972
canonical
uniprot
G5E829
canonical
ensembl
ENSMUSG00000019943
resolver
ensp
ENSMUSP00000020107
resolver
ensp
ENSMUSP00000295312
resolver
ensp
ENSMUSP00000295314
resolver
ensp
ENSMUSP00000295315
resolver
ensp
ENSMUSP00000295317
resolver
enst
ENSMUST00000020107
resolver
genesymbol
Atp2b1
resolver
uniprot_entry
AT2B1_MOUSE
resolver
amino_acid_sequence
MGDMANNSVAYSGVKNSLKEANHDGDFGITLTELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRHVGNKTECALLGFLLDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSFRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDVVTGLTCIAVVGIEDPVRPEVPEAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPEFRIEDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVDSGIHLTIEMNKSATSSSPGSPLHSLETSL
uniprot
proteins
ec_number
7.2.2.10
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis (PubMed:16956963, PubMed:22311909, PubMed:23266958, PubMed:24805951, PubMed:26392310, PubMed:28827723, PubMed:29950683). Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction (PubMed:22311909, PubMed:24805951, PubMed:29950683). Positively regulates bone mineralization through absorption of calcium from the intestine (PubMed:23266958, PubMed:26392310). Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (PubMed:23266958). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (By similarity). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles. {ECO:0000250|UniProtKB:P20020, ECO:0000269|PubMed:16956963, ECO:0000269|PubMed:22311909, ECO:0000269|PubMed:23266958, ECO:0000269|PubMed:24805951, ECO:0000269|PubMed:26392310, ECO:0000269|PubMed:28827723, ECO:0000269|PubMed:29950683, ECO:0000269|PubMed:30862855}.
uniprot
proteins
mass_dalton
134747
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIB subfamily
uniprot
proteins
pubmed
12209837
uniprot
proteins
pubmed
15178683
uniprot
proteins
pubmed
16956963
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22311909
uniprot
proteins
pubmed
23266958
uniprot
proteins
pubmed
23460639
uniprot
proteins
pubmed
24805951
uniprot
proteins
pubmed
26392310
uniprot
proteins
pubmed
28827723
uniprot
proteins
pubmed
29950683
uniprot
proteins
pubmed
30862855
uniprot
proteins
sequence_length
1220
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20020}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:23460639}. Synapse {ECO:0000269|PubMed:12209837}. Presynaptic cell membrane {ECO:0000269|PubMed:30862855}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:30862855}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with SV2A in photoreceptor synaptic terminals (PubMed:12209837). Colocalizes with NPTN to the immunological synapse (PubMed:28827723). Colocalizes with EPB41 to the basolateral membrane in enterocyte (PubMed:23460639). Preferentially sorted to recycling synaptic vesicles. {ECO:0000269|PubMed:12209837, ECO:0000269|PubMed:23460639, ECO:0000269|PubMed:28827723, ECO:0000269|PubMed:30862855}.
uniprot
proteins
transmembrane_region
TRANSMEM 106..126; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P20020"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P20020"; TRANSMEM 367..386; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P20020"; TRANSMEM 419..439; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 856..876; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 883..903; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 928..948; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P20020"; TRANSMEM 972..991; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P20020"; TRANSMEM 1006..1027; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P20020"; TRANSMEM 1040..1060; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P20020
uniprot
proteins