Kcna5
entrez
25470
canonical
uniprot
P19024
canonical
ensembl
ENSRNOG00000072038
resolver
ensembl
ENSRNOG00055010709
resolver
ensembl
ENSRNOG00060016571
resolver
ensembl
ENSRNOG00065033450
resolver
ensp
ENSRNOP00000105534
resolver
ensp
ENSRNOP00055014535
resolver
ensp
ENSRNOP00060022849
resolver
ensp
ENSRNOP00065047347
resolver
enst
ENSRNOT00000144861
resolver
enst
ENSRNOT00055018093
resolver
enst
ENSRNOT00060028378
resolver
enst
ENSRNOT00065057506
resolver
genesymbol
Kcna5
resolver
uniprot
Q6LEB7
resolver
uniprot_entry
KCNA5_RAT
resolver
uniprot_sec
Q6LEB7
resolver
amino_acid_sequence
MEISLVPLENGSAMTLRGGGEAGASCVQTPRGECGCPPTSGLNNQSKETLLRGRTTLEDANQGGRPLPPMAQELPQPRRLSAEDEEGEGDPGLGTVEEDQAPQDAGSLHHQRVLINISGLRFETQLGTLAQFPNTLLGDPAKRLHYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPVPPQPPAPAPGINGSVSGALSSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNHGSHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEQAALKEEQGNQRRESGLDTGGQRKVSCSKASFCKTGGSLESSDSIRRGSCPLEKCHLKAKSNVDLRRSLYALCLDTSRETDL
uniprot
proteins
function
FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:15618540, PubMed:2361015). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:15618540). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:15618540). Homotetrameric channels display rapid activation and slow inactivation. Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). May play a role in regulating the secretion of insulin in normal pancreatic islets (By similarity). {ECO:0000250|UniProtKB:P22460, ECO:0000250|UniProtKB:Q61762, ECO:0000269|PubMed:15277200, ECO:0000269|PubMed:15618540, ECO:0000269|PubMed:2361015}.
uniprot
proteins
mass_dalton
66553
uniprot
proteins
mutagenesis
MUTAGEN 600..602; /note="TDL->AAA: Loss of interaction with DLG1."; /evidence="ECO:0000269|PubMed:11709425
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:P22460}.; PTM: Sumoylated on Lys-212, and Lys-525, preferentially with SUMO3. Sumoylation regulates the voltage sensitivity of the channel (By similarity). {ECO:0000250|UniProtKB:P22460}.
uniprot
proteins
protein_family
A (Shaker) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv1.5/KCNA5 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
11709425
uniprot
proteins
pubmed
15277200
uniprot
proteins
pubmed
15618540
uniprot
proteins
pubmed
1705709
uniprot
proteins
pubmed
2361015
uniprot
proteins
pubmed
8253777
uniprot
proteins
sequence_length
602
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15618540, ECO:0000269|PubMed:2361015}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 239..260; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 315..336; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 348..368; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 385..405; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 421..442; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 484..512; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:P63142
uniprot
proteins