Plg
entrez
85253
canonical
uniprot
Q01177
canonical
ensembl
ENSRNOG00000017223
resolver
ensembl
ENSRNOG00055027842
resolver
ensembl
ENSRNOG00060009885
resolver
ensembl
ENSRNOG00065029290
resolver
ensp
ENSRNOP00000023370
resolver
ensp
ENSRNOP00055040019
resolver
ensp
ENSRNOP00060013160
resolver
ensp
ENSRNOP00065041809
resolver
enst
ENSRNOT00000023368
resolver
enst
ENSRNOT00055048697
resolver
enst
ENSRNOT00060016838
resolver
enst
ENSRNOT00065050859
resolver
genesymbol
Plg
resolver
uniprot
Q5BKB6
resolver
uniprot
Q9R0W3
resolver
uniprot_entry
PLMN_RAT
resolver
uniprot_sec
Q5BKB6
resolver
uniprot_sec
Q9R0W3
resolver
activity_regulation
ACTIVITY REGULATION: [Plasmin]: Converted into plasmin by tissue-type (PLAT) and urokinase-type (PLAU) plasminogen activator. The activation by PLAT is enhanced by fibrin at the surface of blood clots. The partial proteolysis of fibrin by plasmin mainly exposes C-terminal lysine residues which in turn help recruit and activate plasminogen. The activation by PLAU occurs at the surface of cells and is more specific of extracellular matrix remodeling. Activated by streptokinase. Plasmin activity is also inhibited by SERPINF2; plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot. {ECO:0000250|UniProtKB:P00747}.
uniprot
proteins
amino_acid_sequence
MDHKEIILLFLLFLKPGQGDSLDGYVSTQGASLHSLTKKQLAAGSIADCLAKCEGETDFICRSFQYHSKEQQCVIMAENSKTSSIIRMRDVILFEKRVYLSECKTGIGKGYRGTMSKTKTGVTCQKWSDTSPHVPKYSPSTHPSEGLEENYCRNPDNDEQGPWCYTTDPDQRYEYCNIPECEEECMYCSGEKYEGKISKTMSGLDCQSWDSQSPHAHGYIPAKFPSKNLKMNYCRNPDGEPRPWCFTTDPNKRWEYCDIPRCTTPPPPPGPTYQCLKGRGENYRGTVSVTASGKTCQRWSEQTPHRHNRTPENFPCKNLEENYCRNPDGETAPWCYTTDSQLRWEYCEIPSCGSSVSPDQSDSSVLPEQTPVVQECYQGNGKSYRGTSSTTNTGKKCQSWVSMTPHSHSKTPANFPDAGLEMNYCRNPDNDQRGPWCFTTDPSVRWEYCNLKRCSETGGGVAESAIVPQVPSAPGTSETDCMYGNGKEYRGKTAVTAAGTPCQEWAAQEPHSHRIFTPQTNPRAGLEKNYCRNPDGDVNGPWCYTMNPRKLYDYCNIPLCASLSSFECGKPQVEPKKCPGRVVGGCVANPHSWPWQISLRTRFSGQHFCGGTLISPEWVLTAAHCLEKSSRPEFYKVILGAHEERILGSDVQQIAVTKLVLEPNDADIALLKLSRPATITDNVIPACLPSPNYVVADRTLCYITGWGETKGTPGAGRLKEAQLPVIENKVCNRAEYLNNRVKSTELCAGHLAGGIDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRYVNWIEREMRND
uniprot
proteins
ec_number
3.4.21.7
uniprot
proteins
function
FUNCTION: [Plasmin]: Protease which primary function is to degrade fibrin, the main component of blood clots. Also cleaves other components of blood clots like thrombospondin-1/THBS1 and von Willebrand factor/VWF. Can also directly and/or through the activation of other proteases degrade the various components of the extracellular matrix including collagen, fibronectin and laminin. Thereby, regulates a variety of biological processes including embryonic development, tissue remodeling, and inflammation (By similarity). In ovulation, weakens the walls of the Graafian follicle (PubMed:212205, PubMed:965386). In vitro, it is also able to cleave several complement zymogens, such as C1, C4 and C5 (By similarity). {ECO:0000250|UniProtKB:P00747, ECO:0000269|PubMed:212205, ECO:0000269|PubMed:965386}.; FUNCTION: [Angiostatin]: Has an antiangiogenic activity and inhibits neovascularization. Could act through the inhibition of the ATP synthase subunit ATP5F1A. {ECO:0000250|UniProtKB:P00747}.
uniprot
proteins
mass_dalton
90536
uniprot
proteins
post_translational_modification
PTM: [Plasmin]: Activation requires cleavage in two chains held together by two disulfide bonds. Removal of the activation peptide is also part of the activation mechanisms. {ECO:0000250|UniProtKB:P00747}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
protein_family
Plasminogen subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1645711
uniprot
proteins
pubmed
212205
uniprot
proteins
pubmed
965386
uniprot
proteins
sequence_length
812
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Plasmin]: Secreted {ECO:0000250|UniProtKB:P00747}. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface. {ECO:0000250|UniProtKB:P00747}.; SUBCELLULAR LOCATION: [Angiostatin]: Secreted {ECO:0000250|UniProtKB:P00747}.
uniprot
proteins