PSMA7
entrez
5688
canonical
uniprot
O14818
canonical
ensembl
ENSG00000101182
resolver
ensp
ENSP00000359910
resolver
genesymbol
HEL-S-276
resolver
genesymbol
PSMA7
resolver
genesymbol_syn
HSPC
resolver
hgnc
HGNC:9536
resolver
uniprot
A0A0K0K1K4
resolver
uniprot
B2R515
resolver
uniprot
Q5JXJ2
resolver
uniprot
Q9BR53
resolver
uniprot
Q9H4K5
resolver
uniprot
Q9UEU8
resolver
uniprot_entry
A0A0K0K1K4_HUMAN
resolver
uniprot_entry
PSA7_HUMAN
resolver
uniprot_sec
B2R515
resolver
uniprot_sec
Q5JXJ2
resolver
uniprot_sec
Q9BR53
resolver
uniprot_sec
Q9H4K5
resolver
uniprot_sec
Q9UEU8
resolver
amino_acid_sequence
MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENEKKKQKKAS
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. {ECO:0000269|PubMed:11389899, ECO:0000269|PubMed:11713272, ECO:0000269|PubMed:12119296, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:19442227, ECO:0000269|PubMed:19734229, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
uniprot
proteins
mass_dalton
27887
uniprot
proteins
mutagenesis
MUTAGEN 153; /note="Y->F: Displays impaired G1/S transition and S/G2 progression."; /evidence="ECO:0000269|PubMed:16678104
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by ABL1 or ABL2 leads to an inhibition of proteasomal activity and cell cycle transition blocks. {ECO:0000269|PubMed:16678104}.
uniprot
proteins
protein_family
Peptidase T1A family
uniprot
proteins
pubmed
10748218
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11389899
uniprot
proteins
pubmed
11574696
uniprot
proteins
pubmed
11713272
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12119296
uniprot
proteins
pubmed
12181345
uniprot
proteins
pubmed
14550573
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
14998988
uniprot
proteins
pubmed
15244466
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15987638
uniprot
proteins
pubmed
16251969
uniprot
proteins
pubmed
16678104
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
18202793
uniprot
proteins
pubmed
19362550
uniprot
proteins
pubmed
19442227
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19734229
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23033978
uniprot
proteins
pubmed
23495936
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25599644
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26133119
uniprot
proteins
pubmed
27176742
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
27493187
uniprot
proteins
pubmed
34711951
uniprot
proteins
pubmed
8610016
uniprot
proteins
pubmed
8764072
uniprot
proteins
sequence_length
248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
uniprot
proteins