PDE12
entrez
201626
canonical
uniprot
Q6L8Q7
canonical
ensembl
ENSG00000174840
resolver
ensp
ENSP00000309142
resolver
ensp
ENSP00000420626
resolver
ensp
ENSP00000520545
resolver
enst
ENST00000487257
resolver
enst
ENST00000715954
resolver
genesymbol
PDE12
resolver
hgnc
HGNC:25386
resolver
uniprot
A0ABB0MV04
resolver
uniprot
B4DTU8
resolver
uniprot
F6T1Q0
resolver
uniprot
Q8IYU3
resolver
uniprot
Q8NDU2
resolver
uniprot
Q8TE78
resolver
uniprot_entry
A0ABB0MV04_HUMAN
resolver
uniprot_entry
F6T1Q0_HUMAN
resolver
uniprot_entry
PDE12_HUMAN
resolver
uniprot_sec
B4DTU8
resolver
uniprot_sec
Q8IYU3
resolver
uniprot_sec
Q8NDU2
resolver
uniprot_sec
Q8TE78
resolver
amino_acid_sequence
MWRLPGARAALRVIRTAVEKLSRAEAGSQTAAGAMERAVVRCVPSEPKLSLSFALADGSHKNMQRDQSEPLGRVLSRIATNALKGHAKAAAAKKSRKSRPNASGGAACSGPGPEPAVFCEPVVKLYYREEAVAEDVLNVDAWQDGAVLQIGDVKYKVERNPPAFTELQLPRYIMAGFPVCPKLSLEFGDPASSLFRWYKEAKPGAAEPEVGVPSSLSPSSPSSSWTETDVEERVYTPSNADIGLRLKLHCTPGDGQRFGHSRELESVCVVEAGPGTCTFDHRHLYTKKVTEDALIRTVSYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADVICLQEVDRAVFSDSLVPALEAFGLEGVFRIKQHEGLATFYRKSKFSLLSQHDISFYEALESDPLHKELLEKLVLYPSAQEKVLQRSSVLQVSVLQSTKDSSKRICVANTHLYWHPKGGYIRLIQMAVALAHIRHVSCDLYPGIPVIFCGDFNSTPSTGMYHFVINGSIPEDHEDWASNGEEERCNMSLTHFFKLKSACGEPAYTNYVGGFHGCLDYIFIDLNALEVEQVIPLPSHEEVTTHQALPSVSHPSDHIALVCDLKWK
uniprot
proteins
ec_number
3.1.13.4
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
function
FUNCTION: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:26055709, PubMed:30389976). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709). {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541, ECO:0000269|PubMed:26055709, ECO:0000269|PubMed:30389976}.
uniprot
proteins
mass_dalton
67352
uniprot
proteins
protein_family
CCR4/nocturin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15231837
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21245038
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21666256
uniprot
proteins
pubmed
22285541
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26055709
uniprot
proteins
pubmed
30389976
uniprot
proteins
sequence_length
609
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541}.
uniprot
proteins