Ppp6c
entrez
67857
canonical
uniprot
Q9CQR6
canonical
ensembl
ENSMUSG00000026753
resolver
ensp
ENSMUSP00000028087
resolver
enst
ENSMUST00000028087
resolver
genesymbol
Ppp6c
resolver
uniprot
A2ASL7
resolver
uniprot_entry
PPP6_MOUSE
resolver
uniprot_sec
A2ASL7
resolver
amino_acid_sequence
MAPLDLDKYVEIARQCKYLPENDLKRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:32474700). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (By similarity). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D13 During mitosis, regulates spindle positioning (By similarity). Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (By similarity). Acts as a regulator of innate immunity by mediating dephosphorylation CGAS, STING1 and RIGI (PubMed:32474700). Also participates in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation (By similarity). Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 (PubMed:32474700). CGAS dephosphorylation at 'Ser-420' impairs its ability to bind GTP, thereby inactivating it (PubMed:32474700). {ECO:0000250|UniProtKB:O00743, ECO:0000269|PubMed:32474700}.
uniprot
proteins
mass_dalton
35159
uniprot
proteins
protein_family
PP-6 (PP-V) subfamily
uniprot
proteins
protein_family
PPP phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16769727
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26868000
uniprot
proteins
pubmed
32474700
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:O00743}. Cytoplasm {ECO:0000250|UniProtKB:O00743}.
uniprot
proteins