ING2
entrez
3622
canonical
uniprot
Q9H160
canonical
ensembl
ENSG00000168556
resolver
ensp
ENSP00000307183
resolver
genesymbol
ING2
resolver
genesymbol_syn
ING1L
resolver
hgnc
HGNC:6063
resolver
uniprot
B2RA15
resolver
uniprot
B6ZDS1
resolver
uniprot
O95698
resolver
uniprot_entry
B2RA15_HUMAN
resolver
uniprot_entry
ING2_HUMAN
resolver
uniprot_sec
B6ZDS1
resolver
uniprot_sec
O95698
resolver
amino_acid_sequence
MLGQQQQQLYSSAALLTGERSRLLTCYVQDYLECVESLPHDMQRNVSVLRELDNKYQETLKEIDDVYEKYKKEDDLNQKKRLQQLLQRALINSQELGDEKIQIVTQMLELVENRARQMELHSQCFQDPAESERASDKAKMDSSQPERSSRRPRRQRTSESRDLCHMANGIEDCDDQPPKEKKSKSAKKKKRSKAKQEREASPVEFAIDPNEPTYCLCNQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRGDNEKTMDKSTEKTKKDRRSR
uniprot
proteins
function
FUNCTION: Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). {ECO:0000269|PubMed:11481424, ECO:0000269|PubMed:12859901}.
uniprot
proteins
mass_dalton
32808
uniprot
proteins
post_translational_modification
PTM: Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71. {ECO:0000269|PubMed:20676127}.
uniprot
proteins
protein_family
ING family
uniprot
proteins
pubmed
10072587
uniprot
proteins
pubmed
11481424
uniprot
proteins
pubmed
11784859
uniprot
proteins
pubmed
12859901
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16387653
uniprot
proteins
pubmed
16728974
uniprot
proteins
pubmed
16893883
uniprot
proteins
pubmed
18951897
uniprot
proteins
pubmed
20676127
uniprot
proteins
sequence_length
280
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12859901}. Note=Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.
uniprot
proteins