Hmbox1
entrez
219150
canonical
uniprot
Q8BJA3
canonical
ensembl
ENSMUSG00000021972
resolver
ensp
ENSMUSP00000022544
resolver
ensp
ENSMUSP00000066905
resolver
ensp
ENSMUSP00000135272
resolver
ensp
ENSMUSP00000135372
resolver
ensp
ENSMUSP00000135448
resolver
ensp
ENSMUSP00000207195
resolver
ensp
ENSMUSP00000207196
resolver
ensp
ENSMUSP00000207197
resolver
ensp
ENSMUSP00000207200
resolver
ensp
ENSMUSP00000207201
resolver
ensp
ENSMUSP00000339249
resolver
ensp
ENSMUSP00000339250
resolver
enst
ENSMUST00000175744
resolver
enst
ENSMUST00000176128
resolver
genesymbol
Hmbox1
resolver
uniprot
H3BK67
resolver
uniprot
H3BKM3
resolver
uniprot
Q80WC2
resolver
uniprot
Q8BWE7
resolver
uniprot
Q99LV1
resolver
uniprot_entry
H3BK67_MOUSE
resolver
uniprot_entry
H3BKM3_MOUSE
resolver
uniprot_entry
HMBX1_MOUSE
resolver
uniprot_sec
Q80WC2
resolver
uniprot_sec
Q8BWE7
resolver
uniprot_sec
Q99LV1
resolver
amino_acid_sequence
MLSSFPVVLLETMSHYTDEPRFTIEQIDLLQRLRRTGMTKHEILHALETLDRLDQEHSDKFGRRSSYGGSSYGNSTNNVPASSSTATASTQTQHSGMSPSPSNSYDTSPLPCTTNQNGRENNDRLSTSNGKMSPSRYHANSMGQRSYSFEASEEDLDVDDKVEELMRRDSSVIKEEIKAFLANRRISQAVVAQVTGISQSRISHWLLQQGSDLSEQKKRAFYRWYQLEKTNPGATLSMRPAPIPIEDPEWRQTPPPVSATPGTFRLRRGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNAVIQKPGKKLSDLERVTSLKVYNWFANRRKEIKRRANIAAILESHGIDVQSPGGHSNSDDVDGNDYSEQDDSTSHSDHQDPISLAVEMAAVNHTILALARQGANEIKTEALDDD
uniprot
proteins
function
FUNCTION: Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (By similarity). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (By similarity). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (PubMed:23685356). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (By similarity). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (By similarity). Might also be involved in the DNA damage response at telomeres (By similarity). {ECO:0000250|UniProtKB:Q6NT76, ECO:0000269|PubMed:23685356}.
uniprot
proteins
mass_dalton
47116
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23685356
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23685356}. Cytoplasm {ECO:0000250|UniProtKB:Q6NT76}. Chromosome, telomere {ECO:0000269|PubMed:23685356}. Nucleus, Cajal body {ECO:0000250|UniProtKB:Q6NT76}. Nucleus, PML body {ECO:0000250|UniProtKB:Q6NT76}. Note=Predominantly detected in cytoplasm. Localizes in a dynamic manner to actively processed telomeres. Localizes to the periphery of Cajal bodies. Associates with PML nuclear bodies in telomerase-negative cells. {ECO:0000250|UniProtKB:Q6NT76}.
uniprot
proteins