SPDY1
entrez
245711
canonical
uniprot
Q5MJ70
canonical
ensembl
ENSG00000163806
resolver
ensp
ENSP00000335628
resolver
ensp
ENSP00000368898
resolver
ensp
ENSP00000772271
resolver
genesymbol
SPDY1
resolver
genesymbol
SPDYA
resolver
genesymbol_syn
SPDY1
resolver
genesymbol_syn
SPY1
resolver
hgnc
HGNC:30613
resolver
uniprot
A0A384MTT5
resolver
uniprot
Q53R05
resolver
uniprot
Q5MJ69
resolver
uniprot_entry
A0A384MTT5_HUMAN
resolver
uniprot_entry
SPDYA_HUMAN
resolver
uniprot_sec
Q53R05
resolver
uniprot_sec
Q5MJ69
resolver
amino_acid_sequence
MRHNQMCCETPPTVTVYVKSGSNRSHQPKKPITLKRPICKDNWQAFEKNTHNNNKSKRPKGPCLVIQRQDMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTISEHTRINFFIALYLANTVEEDEEETKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRDEVQLPRGPSATPVDCSLCGKKRRYVRLGLSSSSSLSSHTAGVTEKHSQDSYNSLSMDIIGDPSQAYTGSEVVNDHQSNKGKKTNFLKKDKSMEWFTGSEE
uniprot
proteins
function
FUNCTION: Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation (PubMed:28666995). Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962). {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:12839962, ECO:0000269|PubMed:12972555, ECO:0000269|PubMed:28666995}.
uniprot
proteins
mass_dalton
36463
uniprot
proteins
mutagenesis
MUTAGEN 97; /note="D->N: Loss of CDK2 activation; when associated with Q-135."; /evidence="ECO:0000269|PubMed:28666995"; MUTAGEN 135; /note="E->Q: Loss of CDK2 activation; when associated with N-97."; /evidence="ECO:0000269|PubMed:28666995
uniprot
proteins
protein_family
Speedy/Ringo family
uniprot
proteins
pubmed
11980914
uniprot
proteins
pubmed
12839962
uniprot
proteins
pubmed
12972555
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15611625
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
28666995
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:12972555}.
uniprot
proteins