Syt11
entrez
229521
canonical
uniprot
Q9R0N3
canonical
ensembl
ENSMUSG00000068923
resolver
ensp
ENSMUSP00000088464
resolver
ensp
ENSMUSP00000103129
resolver
ensp
ENSMUSP00000313011
resolver
enst
ENSMUST00000090945
resolver
enst
ENSMUST00000107505
resolver
genesymbol
Syt11
resolver
uniprot
Q3TPH5
resolver
uniprot
Q7TQG8
resolver
uniprot_entry
Q3TPH5_MOUSE
resolver
uniprot_entry
SYT11_MOUSE
resolver
uniprot_sec
Q7TQG8
resolver
amino_acid_sequence
MAEITNIRPSFDVSPVAAGLIGASVLVVCVSVTVFVWTCCHQQAEKKHKTPPYKFIHMLKGISIYPETLSNKKKIIKVRRDKDGPRRESGRGNLLINAESGLLSHDKDPRGPSPASCMDQLPIKRDYGEELRSPMTSLTPGESKATSPSSPEEDVMLGSLTFSVDYNFPKKALVVTIQEAHGLPVMDDQTQGSDPYIKMTILPDKRHRVKTRVLRKTLDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEVMVPLAGVDPSTGKVQLTRDIIKRNIQKCISRGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSGNPYVKVNVYYGRKRIAKKKTHVKKCTLNPVFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNEVVGRLILGAHSVTTSGAEHWREVCESPRKPIAKWHSLSEY
uniprot
proteins
function
FUNCTION: Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+) (Probable). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval (PubMed:29311685). Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process (PubMed:29311685). Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity (PubMed:30808661). In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis (PubMed:23303671, PubMed:28686317). In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (PubMed:26450452). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed:27278822). {ECO:0000269|PubMed:23303671, ECO:0000269|PubMed:26450452, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28686317, ECO:0000269|PubMed:29311685, ECO:0000269|PubMed:30808661, ECO:0000305}.
uniprot
proteins
mass_dalton
48333
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, at least by PRKN, and targeted to the proteasome complex for degradation. Ubiquitination is inhibited by ATP13A2. {ECO:0000250|UniProtKB:Q9BT88}.
uniprot
proteins
protein_family
Synaptotagmin family
uniprot
proteins
pubmed
10531343
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23303671
uniprot
proteins
pubmed
24882364
uniprot
proteins
pubmed
26450452
uniprot
proteins
pubmed
27278822
uniprot
proteins
pubmed
28686317
uniprot
proteins
pubmed
29311685
uniprot
proteins
pubmed
30808661
uniprot
proteins
sequence_length
430
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:30808661}; Single-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000269|PubMed:30808661}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:28686317}; Single-pass membrane protein {ECO:0000305}. Recycling endosome membrane {ECO:0000269|PubMed:23303671, ECO:0000269|PubMed:28686317}; Single-pass membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:23303671, ECO:0000269|PubMed:26450452, ECO:0000269|PubMed:28686317}; Single-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:23303671, ECO:0000269|PubMed:28686317}. Cell projection, axon {ECO:0000269|PubMed:30808661}. Cell projection, dendrite {ECO:0000269|PubMed:30808661}. Postsynaptic density {ECO:0000269|PubMed:30808661}. Recycling endosome membrane {ECO:0000250|UniProtKB:O08835}; Single-pass membrane protein {ECO:0000250|UniProtKB:O08835}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:O08835}; Single-pass membrane protein {ECO:0000250|UniProtKB:O08835}. Perikaryon {ECO:0000250|UniProtKB:O08835}. Note=Localized in vesicles that travels in axonal and dendritic shafts in both anterograde and retrograde directions (PubMed:30808661). In macrophages and microglia, recruited in phagosomes at early stages of phagocytosis (PubMed:23303671, PubMed:28686317). {ECO:0000269|PubMed:23303671, ECO:0000269|PubMed:28686317, ECO:0000269|PubMed:30808661}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins