Retsat
entrez
67442
canonical
uniprot
Q64FW2
canonical
ensembl
ENSMUSG00000056666
resolver
ensp
ENSMUSP00000068568
resolver
enst
ENSMUST00000070597
resolver
genesymbol
Retsat
resolver
genesymbol_syn
Ppsig
resolver
uniprot
Q149J8
resolver
uniprot
Q3UNN9
resolver
uniprot
Q78JX8
resolver
uniprot
Q8VHE7
resolver
uniprot
Q9CW85
resolver
uniprot_entry
RETST_MOUSE
resolver
uniprot_sec
Q149J8
resolver
uniprot_sec
Q3UNN9
resolver
uniprot_sec
Q78JX8
resolver
uniprot_sec
Q8VHE7
resolver
uniprot_sec
Q9CW85
resolver
amino_acid_sequence
MWITALLLAVLLLVILHRVYVGLYAASSPNPFAEDVKRPPEPLVTDKEARKKVLKQAFSVSRVPEKLDAVVIGSGIGGLASAAVLAKAGKRVLVLEQHTKAGGCCHTFGENGLEFDTGIHYIGRMREGNIGRFILDQITEGQLDWAPMASPFDLMILEGPNGRKEFPMYSGRKEYIQGLKKKFPKEEAVIDKYMELVKVVARGVSHAVLLKFLPLPLTQLLSKFGLLTRFSPFCRASTQSLAEVLQQLGASRELQAVLSYIFPTYGVTPSHTAFSLHALLVDHYIQGAYYPRGGSSEIAFHTIPLIQRAGGAVLTRATVQSVLLDSAGRACGVSVKKGQELVNIYCPVVISNAGMFNTYQHLLPETVRHLPDVKKQLAMVRPGLSMLSIFICLKGTKEDLKLQSTNYYVYFDTDMDKAMERYVSMPKEKAPEHIPLLFIAFPSSKDPTWEERFPDRSTMTALVPMAFEWFEEWQEEPKGKRGVDYETLKNAFVEASMSVIMKLFPQLEGKVESVTGGSPLTNQYYLAAPRGATYGADHDLARLHPHAMASIRAQTPIPNLYLTGQDIFTCGLMGALQGALLCSSAILKRNLYSDLQALGSKVKAQKKKM
uniprot
proteins
ec_number
1.3.99.23
uniprot
proteins
function
FUNCTION: Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol (PubMed:15358783, PubMed:17253779, PubMed:19139408). Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers (PubMed:15358783). May play a role in the metabolism of vitamin A (PubMed:15358783, PubMed:17253779). Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP (PubMed:28855500). Required for adipocyte differentiation in a 3T3-L1 cell culture model (PubMed:19139408). This effect does not seem to mimic the in vivo situation in which animals show increased adiposity in the absence of RETSAT (PubMed:19940255). {ECO:0000269|PubMed:15358783, ECO:0000269|PubMed:17253779, ECO:0000269|PubMed:19139408, ECO:0000269|PubMed:19940255, ECO:0000269|PubMed:28855500, ECO:0000305|PubMed:19940255}.
uniprot
proteins
mass_dalton
67334
uniprot
proteins
mutagenesis
MUTAGEN 1..17; /note="Missing: Loss of localization to the endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:19139408"; MUTAGEN 91..96; /note="Missing: Loss of catalytic activity, as measured by the saturation of retinol to 13,14-dihydroretinol. Loss of adipocyte differentiation in a 3T3-L1 cell culture model."; /evidence="ECO:0000269|PubMed:19139408"; MUTAGEN 96; /note="E->A: Loss of catalytic activity, as measured by the saturation of retinol to 13,14-dihydroretinol. Loss of adipocyte differentiation in a 3T3-L1 cell culture model."; /evidence="ECO:0000269|PubMed:19139408
uniprot
proteins
protein_family
Carotenoid/retinoid oxidoreductase family
uniprot
proteins
protein_family
CrtISO subfamily
uniprot
proteins
pubmed
11753649
uniprot
proteins
pubmed
15358783
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17253779
uniprot
proteins
pubmed
18289917
uniprot
proteins
pubmed
19139408
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19940255
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28855500
uniprot
proteins
sequence_length
609
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15358783, ECO:0000269|PubMed:19139408}; Peripheral membrane protein {ECO:0000269|PubMed:15358783}.
uniprot
proteins