Fbp1
entrez
14121
canonical
uniprot
Q9QXD6
canonical
ensembl
ENSMUSG00000069805
resolver
ensp
ENSMUSP00000090564
resolver
enst
ENSMUST00000092888
resolver
genesymbol
Fbp1
resolver
genesymbol_syn
Fbp
resolver
genesymbol_syn
Fbp3
resolver
uniprot
P97323
resolver
uniprot
Q3UEH1
resolver
uniprot_entry
F16P1_MOUSE
resolver
uniprot_sec
P97323
resolver
uniprot_sec
Q3UEH1
resolver
activity_regulation
ACTIVITY REGULATION: Subject to complex allosteric regulation. The enzyme can assume an active R-state, or an inactive T-state. Intermediate conformations may exist. AMP acts as an allosteric inhibitor. AMP binding affects the turnover of bound substrate and not the affinity for substrate. Fructose 2,6-bisphosphate acts as a competitive inhibitor. Fructose 2,6-bisphosphate and AMP have synergistic effects (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MANHAPFETDISTLTRFVMEQGRKAQGTGELTQLLNSLCTAIKAISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEENTNAIIIEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKKSTDEPSEKDALQPGRDLVAAGYALYGSATMLVLAMDCGVNCFMLDPSIGEFIMVDRDVKMKKKGNIYSLNEGYAKDFDPAINEYLQRKKFPPDGSAPYGARYVGSMVADIHRTLVYGGIFLYPANKKSPSGKLRLLYECNPIAYVMEKAGGLATTGDKDILDIVPTEIHQKAPVVMGSSEDVQEFLEIYRKHKAK
uniprot
proteins
ec_number
3.1.3.11
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:20719858}.
uniprot
proteins
mass_dalton
36912
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
uniprot
proteins
protein_family
FBPase class 1 family
uniprot
proteins
pubmed
11250076
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16497803
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18375435
uniprot
proteins
pubmed
20719858
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
9106734
uniprot
proteins
sequence_length
338
uniprot
proteins