CDK5RAP1
entrez
51654
canonical
uniprot
Q96SZ6
canonical
ensembl
ENSG00000101391
resolver
ensp
ENSP00000217372
resolver
ensp
ENSP00000341840
resolver
ensp
ENSP00000350558
resolver
ensp
ENSP00000544322
resolver
ensp
ENSP00000649997
resolver
ensp
ENSP00000708271
resolver
genesymbol
CDK5RAP1
resolver
genesymbol_syn
C20orf34
resolver
hgnc
HGNC:15880
resolver
uniprot
A0A0S2Z592
resolver
uniprot
A0A0S2Z5J9
resolver
uniprot
A8K7R0
resolver
uniprot
Q53H36
resolver
uniprot
Q5QP46
resolver
uniprot
Q5QP47
resolver
uniprot
Q5QP48
resolver
uniprot
Q675N4
resolver
uniprot
Q675N5
resolver
uniprot
Q9BVG6
resolver
uniprot
Q9BWZ5
resolver
uniprot
Q9H859
resolver
uniprot
Q9NZZ9
resolver
uniprot
Q9Y3F0
resolver
uniprot_entry
A0A0S2Z592_HUMAN
resolver
uniprot_entry
A0A0S2Z5J9_HUMAN
resolver
uniprot_entry
CK5P1_HUMAN
resolver
uniprot_entry
Q53H36_HUMAN
resolver
uniprot_sec
A8K7R0
resolver
uniprot_sec
Q5QP46
resolver
uniprot_sec
Q5QP47
resolver
uniprot_sec
Q5QP48
resolver
uniprot_sec
Q675N4
resolver
uniprot_sec
Q675N5
resolver
uniprot_sec
Q9BVG6
resolver
uniprot_sec
Q9BWZ5
resolver
uniprot_sec
Q9H859
resolver
uniprot_sec
Q9NZZ9
resolver
uniprot_sec
Q9Y3F0
resolver
amino_acid_sequence
MHPLQCVLQVQRSLGWGPLASVSWLSLRMCRAHSSLSSTMCPSPERQEDGARKDFSSRLAAGPTFQHFLKSASAPQEKLSSEVEDPPPYLMMDELLGRQRKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKALKTRRPRSRVPLRIGILGCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDETYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQVFLPPRPPKVLGLQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAMRRGYSREAYVELVHHIRESIPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITIFREEATKANQTSVGCTQLVLVEGLSKRSATDLCGRNDGNLKVIFPDAEMEDVNNPGLRVRAQPGDYVLVKITSASSQTLRGHVLCRTTLRDSSAYC
uniprot
proteins
ec_number
2.8.4.3
uniprot
proteins
function
FUNCTION: Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:22422838, PubMed:25738458, PubMed:28981754). Essential for efficient and highly accurate protein translation by the ribosome (PubMed:22422838, PubMed:25738458, PubMed:28981754). Specifically inhibits CDK5 activation by CDK5R1 (PubMed:11882646). Essential for efficient mitochondrial protein synthesis and respiratory chain; shows pathological consequences in mitochondrial disease (PubMed:25738458). {ECO:0000269|PubMed:11882646, ECO:0000269|PubMed:22422838, ECO:0000269|PubMed:25738458, ECO:0000269|PubMed:28981754}.
uniprot
proteins
mass_dalton
67689
uniprot
proteins
mutagenesis
MUTAGEN 258; /note="C->A: Loss of mitochondrial tRNAs methylthiotransferase activity; when associated with A-262 and A-265."; /evidence="ECO:0000269|PubMed:25738458"; MUTAGEN 262; /note="C->A: Loss of mitochondrial tRNAs methylthiotransferase activity; when associated with A-258 and A-265."; /evidence="ECO:0000269|PubMed:25738458"; MUTAGEN 265; /note="C->A: Loss of mitochondrial tRNAs methylthiotransferase activity; when associated with A-258 and A-262."; /evidence="ECO:0000269|PubMed:25738458
uniprot
proteins
protein_family
Methylthiotransferase family
uniprot
proteins
protein_family
MiaB subfamily
uniprot
proteins
pubmed
10721722
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
11882646
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15329498
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22422838
uniprot
proteins
pubmed
25738458
uniprot
proteins
pubmed
28981754
uniprot
proteins
sequence_length
601
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22422838}.
uniprot
proteins