CD86
entrez
942
canonical
uniprot
P42081
canonical
ensembl
ENSG00000114013
resolver
ensp
ENSP00000264468
resolver
ensp
ENSP00000332049
resolver
ensp
ENSP00000377248
resolver
ensp
ENSP00000418988
resolver
ensp
ENSP00000420230
resolver
genesymbol
CD86
resolver
genesymbol_syn
CD28LG2
resolver
hgnc
HGNC:1705
resolver
uniprot
A0A0X9R4E0
resolver
uniprot
A0N0P0
resolver
uniprot
A8K632
resolver
uniprot
B7Z2F3
resolver
uniprot
B7Z702
resolver
uniprot
E7ETN5
resolver
uniprot
E9PC27
resolver
uniprot
Q13655
resolver
uniprot
Q6FHB1
resolver
uniprot
Q6GTS4
resolver
uniprot
Q7M4L5
resolver
uniprot_entry
A0A0X9R4E0_HUMAN
resolver
uniprot_entry
A8K632_HUMAN
resolver
uniprot_entry
CD86_HUMAN
resolver
uniprot_sec
A0N0P0
resolver
uniprot_sec
B7Z2F3
resolver
uniprot_sec
B7Z702
resolver
uniprot_sec
E7ETN5
resolver
uniprot_sec
E9PC27
resolver
uniprot_sec
Q13655
resolver
uniprot_sec
Q6FHB1
resolver
uniprot_sec
Q6GTS4
resolver
uniprot_sec
Q7M4L5
resolver
amino_acid_sequence
MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREKIHIPERSDEAQRVFKSSKTSSCDKSDTCF
uniprot
proteins
function
FUNCTION: Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:12196291, PubMed:7694363). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:12196291, PubMed:7694363). May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming (PubMed:11279501). {ECO:0000250|UniProtKB:P42082, ECO:0000269|PubMed:11279501, ECO:0000269|PubMed:12196291, ECO:0000269|PubMed:7527824, ECO:0000269|PubMed:7694363}.; FUNCTION: [Isoform 2]: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. {ECO:0000269|PubMed:7527824}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus subgroup B. {ECO:0000269|PubMed:16920215}.
uniprot
proteins
mass_dalton
37682
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. {ECO:0000269|PubMed:12582153}.
uniprot
proteins
pubmed
11162656
uniprot
proteins
pubmed
11279501
uniprot
proteins
pubmed
12196291
uniprot
proteins
pubmed
12582153
uniprot
proteins
pubmed
12606712
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16920215
uniprot
proteins
pubmed
30918073
uniprot
proteins
pubmed
7520767
uniprot
proteins
pubmed
7527824
uniprot
proteins
pubmed
7541777
uniprot
proteins
pubmed
7694153
uniprot
proteins
pubmed
7694363
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7694363}; Single-pass type I membrane protein {ECO:0000269|PubMed:11279501}.
uniprot
proteins
transmembrane_region
TRANSMEM 248..268; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins