Skap2
entrez
54353
canonical
uniprot
Q3UND0
canonical
ensembl
ENSMUSG00000059182
resolver
ensp
ENSMUSP00000145462
resolver
genesymbol
Skap2
resolver
genesymbol_syn
Prap
resolver
genesymbol_syn
Ra70
resolver
genesymbol_syn
Saps
resolver
genesymbol_syn
Scap2
resolver
genesymbol_syn
Skap55r
resolver
uniprot
Q8BK74
resolver
uniprot
Q9Z2K4
resolver
uniprot_entry
SKAP2_MOUSE
resolver
uniprot_sec
Q8BK74
resolver
uniprot_sec
Q9Z2K4
resolver
amino_acid_sequence
MPNPSCTSSPGPLPEEIRNLLADVETFVADTLKGENLSKKAKEKRESLIKKIKDVKSVYLQEFQDKGDAEDGDEYDDPFAGPADTISLASERYDKDDDGPSDGNQFPPIAAQDLPFVIKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYDVRMNNTLRKDGKKDCCFEICAPDKRIYQFTAASPKDAEEWVQQLKFILQDLGSDVIPEDDEERGELYDDVDHPAAVSSPQRSQPIDDEIYEELPEEEEDTASVKMDEQGKGSRDSVHHTSGDKSTDYANFYQGLWDCTGALSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYLMEMYDI
uniprot
proteins
function
FUNCTION: May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:11063873, ECO:0000269|PubMed:15894167, ECO:0000269|PubMed:16135797}.
uniprot
proteins
mass_dalton
40712
uniprot
proteins
mutagenesis
MUTAGEN 260; /note="Y->F: Abolishes interaction with FYN, phosphorylation by FYN, and effects on cell growth."; /evidence="ECO:0000269|PubMed:11063873
uniprot
proteins
post_translational_modification
PTM: Dephosphorylated on Tyr-75 by PTPN22 (By similarity). Phosphorylated by FYN on Tyr-260. In case of infection with Y.pseudotuberculosis, dephosphorylated by bacterial phosphatase yopH. {ECO:0000250, ECO:0000269|PubMed:11063873, ECO:0000269|PubMed:11207596, ECO:0000269|PubMed:15894167}.
uniprot
proteins
protein_family
SKAP family
uniprot
proteins
pubmed
10469599
uniprot
proteins
pubmed
11063873
uniprot
proteins
pubmed
11207596
uniprot
proteins
pubmed
12893833
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15894167
uniprot
proteins
pubmed
16135797
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17003372
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19026786
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9755858
uniprot
proteins
sequence_length
358
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11063873, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:19026786}. Note=Membrane ruffles of macrophages. Perikarya and dendrites from neurons.
uniprot
proteins