AKT3
entrez
10000
canonical
uniprot
Q9Y243
canonical
ensembl
ENSG00000117020
resolver
ensembl
ENSG00000275199
resolver
ensp
ENSP00000263826
resolver
ensp
ENSP00000336943
resolver
ensp
ENSP00000355498
resolver
ensp
ENSP00000500582
resolver
ensp
ENSP00000500597
resolver
ensp
ENSP00000506399
resolver
ensp
ENSP00000506695
resolver
enst
ENST00000492957
resolver
enst
ENST00000672578
resolver
enst
ENST00000681794
resolver
genesymbol
AKT3
resolver
genesymbol_syn
PKBG
resolver
hgnc
HGNC:393
resolver
uniprot
A0A5F9ZHU3
resolver
uniprot
A0A7P0TB32
resolver
uniprot
A0A7P0TBJ6
resolver
uniprot
Q0VAA6
resolver
uniprot
Q5VTI1
resolver
uniprot
Q5VTI2
resolver
uniprot
Q96QV3
resolver
uniprot
Q9UFP5
resolver
uniprot_entry
A0A5F9ZHU3_HUMAN
resolver
uniprot_entry
A0A7P0TB32_HUMAN
resolver
uniprot_entry
A0A7P0TBJ6_HUMAN
resolver
uniprot_entry
AKT3_HUMAN
resolver
uniprot_sec
Q0VAA6
resolver
uniprot_sec
Q5VTI1
resolver
uniprot_sec
Q5VTI2
resolver
uniprot_sec
Q96QV3
resolver
uniprot_sec
Q9UFP5
resolver
activity_regulation
ACTIVITY REGULATION: Two specific sites, one in the kinase domain (Thr-305) and the other in the C-terminal regulatory region (Ser-472), need to be phosphorylated for its full activation (By similarity). IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
uniprot
proteins
disease_involvement
DISEASE: Note=AKT3 is a key modulator of several tumors like melanoma, glioma and ovarian cancer. Active AKT3 increases progressively during melanoma tumor progression with highest levels present in advanced-stage metastatic melanomas. Promotes melanoma tumorigenesis by decreasing apoptosis. Plays a key role in the genesis of ovarian cancers through modulation of G2/M phase transition. With AKT2, plays a pivotal role in the biology of glioblastoma.; DISEASE: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 (MPPH2) [MIM:615937]: A syndrome characterized by megalencephaly, hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome. {ECO:0000269|PubMed:22500628, ECO:0000269|PubMed:22729223, ECO:0000269|PubMed:22729224, ECO:0000269|PubMed:23745724}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269|PubMed:18524868, ECO:0000269|PubMed:21191416}.
uniprot
proteins
mass_dalton
55775
uniprot
proteins
mutagenesis
MUTAGEN 305; /note="T->A: No activation after pervanadate treatment."; /evidence="ECO:0000269|PubMed:11387345"; MUTAGEN 305; /note="T->D: 2-fold increase of phosphorylation steady state level, no activation after pervanadate treatment."; /evidence="ECO:0000269|PubMed:11387345"; MUTAGEN 447; /note="T->A: No effect."; /evidence="ECO:0000269|PubMed:11387345"; MUTAGEN 447; /note="T->D: No effect."; /evidence="ECO:0000269|PubMed:11387345"; MUTAGEN 472; /note="S->A: 67% decrease of activity after pervanadate treatment."; /evidence="ECO:0000269|PubMed:10092583"; MUTAGEN 472; /note="S->D: 1.4-fold increase of phosphorylation steady state level, 50% decrease of activity after pervanadate treatment."; /evidence="ECO:0000269|PubMed:10092583
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Thr-305 and Ser-472 is required for full activity (PubMed:12162751, PubMed:9512493). Phosphorylation of the activation loop at Thr-305 by PDPK1/PDK1 is a prerequisite for full activation (PubMed:9512493). Phosphorylation at Ser-472 by mTORC2 in response to growth factors plays a key role in AKT1 activation by facilitating subsequent phosphorylation of the activation loop by PDPK1/PDK1 (By similarity). {ECO:0000250|UniProtKB:Q60823, ECO:0000269|PubMed:12162751, ECO:0000269|PubMed:9512493}.; PTM: Ubiquitinated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome. {ECO:0000269|PubMed:12162751, ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:9512493}.; PTM: O-GlcNAcylation at Thr-302 and Thr-309 inhibits activating phosphorylation at Thr-305 via disrupting the interaction between AKT and PDPK1/PDK1. {ECO:0000250|UniProtKB:P31749}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
RAC subfamily
uniprot
proteins
pubmed
10092583
uniprot
proteins
pubmed
10208883
uniprot
proteins
pubmed
10491192
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11387345
uniprot
proteins
pubmed
11707444
uniprot
proteins
pubmed
11839817
uniprot
proteins
pubmed
12162751
uniprot
proteins
pubmed
15466193
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16540465
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17178867
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18524868
uniprot
proteins
pubmed
18813315
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19713527
uniprot
proteins
pubmed
20018949
uniprot
proteins
pubmed
20059950
uniprot
proteins
pubmed
20167810
uniprot
proteins
pubmed
21191416
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21620960
uniprot
proteins
pubmed
22500628
uniprot
proteins
pubmed
22729223
uniprot
proteins
pubmed
22729224
uniprot
proteins
pubmed
23745724
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9512493
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20018949}. Cytoplasm {ECO:0000269|PubMed:20018949}. Membrane {ECO:0000269|PubMed:20018949}; Peripheral membrane protein {ECO:0000269|PubMed:20018949}. Note=Membrane-associated after cell stimulation leading to its translocation.
uniprot
proteins