PSMC3IP
entrez
29893
canonical
uniprot
Q9P2W1
canonical
ensembl
ENSG00000131470
resolver
ensp
ENSP00000253789
resolver
ensp
ENSP00000377384
resolver
ensp
ENSP00000468188
resolver
enst
ENST00000587209
resolver
genesymbol
PSMC3IP
resolver
genesymbol_syn
HOP2
resolver
genesymbol_syn
TBPIP
resolver
hgnc
HGNC:17928
resolver
uniprot
A0A158RUX1
resolver
uniprot
C5ILB7
resolver
uniprot
K7ERB6
resolver
uniprot
Q14458
resolver
uniprot
Q8WXG2
resolver
uniprot
Q96HA2
resolver
uniprot_entry
A0A158RUX1_HUMAN
resolver
uniprot_entry
HOP2_HUMAN
resolver
uniprot_entry
K7ERB6_HUMAN
resolver
uniprot_sec
C5ILB7
resolver
uniprot_sec
Q14458
resolver
uniprot_sec
Q8WXG2
resolver
uniprot_sec
Q96HA2
resolver
amino_acid_sequence
MSKGRAEAAAGAAGILLRYLQEQNRPYSSQDVFGNLQREHGLGKAVVVKTLEQLAQQGKIKEKMYGKQKIYFADQDQFDMVSDADLQVLDGKIVALTAKVQSLQQSCRYMEAELKELSSALTTPEMQKEIQELKKECAGYRERLKNIKAATNHVTPEEKEQVYRERQKYCKEWRKRKRMATELSDAILEGYPKSKKQFFEEVGIETDEDYNVTLPDP
uniprot
proteins
disease_involvement
DISEASE: Ovarian dysgenesis 3 (ODG3) [MIM:614324]: A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. {ECO:0000269|PubMed:21963259}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. {ECO:0000269|PubMed:10806355, ECO:0000269|PubMed:16407260, ECO:0000269|PubMed:21963259}.
uniprot
proteins
mass_dalton
24906
uniprot
proteins
post_translational_modification
PTM: PTM: Phosphorylated by PKA, PKC and MAPK. {ECO:0000250}.
uniprot
proteins
protein_family
HOP2 family
uniprot
proteins
pubmed
10806355
uniprot
proteins
pubmed
11739747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16407260
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17716379
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21963259
uniprot
proteins
pubmed
7490091
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11739747}.
uniprot
proteins