SPTY2D1
entrez
144108
canonical
uniprot
Q68D10
canonical
ensembl
ENSG00000179119
resolver
ensp
ENSP00000337991
resolver
genesymbol
SPTY2D1
resolver
hgnc
HGNC:26818
resolver
uniprot
Q6AWA5
resolver
uniprot
Q6MZI5
resolver
uniprot
Q7Z390
resolver
uniprot
Q7Z470
resolver
uniprot
Q86VG8
resolver
uniprot
Q8N3E7
resolver
uniprot
Q8N417
resolver
uniprot
Q8N8I3
resolver
uniprot_entry
SPT2_HUMAN
resolver
uniprot_sec
Q6AWA5
resolver
uniprot_sec
Q6MZI5
resolver
uniprot_sec
Q7Z390
resolver
uniprot_sec
Q7Z470
resolver
uniprot_sec
Q86VG8
resolver
uniprot_sec
Q8N3E7
resolver
uniprot_sec
Q8N417
resolver
uniprot_sec
Q8N8I3
resolver
amino_acid_sequence
MDFREILMIASKGQGVNNVPKRYSLAVGPPKKDPKVKGVQSAAVQAFLKRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKRQATESHTSQGTDREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSETISSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRYMESSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKRR
uniprot
proteins
function
FUNCTION: Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026). {ECO:0000250|UniProtKB:E1BUG7, ECO:0000269|PubMed:23378026}.
uniprot
proteins
mass_dalton
75599
uniprot
proteins
mutagenesis
MUTAGEN 641; /note="M->A: Strongly reduces affinity for histones."; /evidence="ECO:0000269|PubMed:26109053"; MUTAGEN 651..652; /note="EE->AA: Strongly reduces affinity for histones."; /evidence="ECO:0000269|PubMed:26109053"; MUTAGEN 658..659; /note="LG->AN: Strongly reduces affinity for histones."; /evidence="ECO:0000269|PubMed:26109053"; MUTAGEN 662..663; /note="ED->AA: Strongly reduces affinity for histones."; /evidence="ECO:0000269|PubMed:26109053
uniprot
proteins
protein_family
SPT2 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23378026
uniprot
proteins
pubmed
26109053
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
33857403
uniprot
proteins
sequence_length
685
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:E1BUG7}.
uniprot
proteins