SLC25A3
entrez
5250
canonical
uniprot
Q00325
canonical
ensembl
ENSG00000075415
resolver
ensp
ENSP00000188376
resolver
ensp
ENSP00000228318
resolver
ensp
ENSP00000448708
resolver
genesymbol
SLC25A3
resolver
genesymbol_syn
PHC
resolver
hgnc
HGNC:10989
resolver
uniprot
A0A024RBE8
resolver
uniprot
A0A024RBH9
resolver
uniprot
B3KS34
resolver
uniprot
Q7Z7N7
resolver
uniprot
Q96A03
resolver
uniprot_entry
A0A024RBE8_HUMAN
resolver
uniprot_entry
A0A024RBH9_HUMAN
resolver
uniprot_entry
S25A3_HUMAN
resolver
uniprot_sec
B3KS34
resolver
uniprot_sec
Q7Z7N7
resolver
uniprot_sec
Q96A03
resolver
amino_acid_sequence
MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEEQYSCDYGSGRFFILCGLGGIISCGTTHTALVPLDLVKCRMQVDPQKYKGIFNGFSVTLKEDGVRGLAKGWAPTFLGYSMQGLCKFGFYEVFKVLYSNMLGEENTYLWRTSLYLAASASAEFFADIALAPMEAAKVRIQTQPGYANTLRDAAPKMYKEEGLKAFYKGVAPLWMRQIPYTMMKFACFERTVEALYKFVVPKPRSECSKPEQLVVTFVAGYIAGVFCAIVSHPADSVVSVLNKEKGSSASLVLKRLGFKGVWKGLFARIIMIGTLTALQWFIYDSVKVYFRLPRPPPPEMPESLKKKLGLTQ
uniprot
proteins
disease_involvement
DISEASE: Mitochondrial phosphate carrier deficiency (MPCD) [MIM:610773]: An autosomal recessive disorder of oxidative phosphorylation. Patients have lactic acidosis, hypertrophic cardiomyopathy and muscular hypotonia and die within the first year of life. {ECO:0000269|PubMed:17273968}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment (By similarity) (PubMed:17273968, PubMed:29237729). Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP (By similarity) (PubMed:17273968). Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (PubMed:29237729). May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (By similarity). {ECO:0000250|UniProtKB:P12234, ECO:0000250|UniProtKB:P16036, ECO:0000269|PubMed:17273968, ECO:0000269|PubMed:29237729}.
uniprot
proteins
mass_dalton
40095
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17273968
uniprot
proteins
pubmed
1777677
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29237729
uniprot
proteins
pubmed
40652815
uniprot
proteins
pubmed
8144629
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:40652815}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P12234}.
uniprot
proteins
transmembrane_region
TRANSMEM 64..86; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 122..141; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 162..183; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 219..238; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 262..284; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 315..333; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins