C0HME6
uniprot
C0HME6
canonical
amino_acid_sequence
MASEAEGAGTRGSGPRELSRYSPPPLLPVAVRSHGPTLPYGRGPQQGPQSDQEREQAQAQPTPRASDQTHQVRAGHDSGGVWLCPVRAARHGVTEGLQGQTGPQIYQEKGGDAHPRQEEAGGAEQRTGRHEESCCQERLSPSPALSLK
uniprot
proteins
function
FUNCTION: Inhibits C2CD2L/TMEM24-dependent transport of phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:33479206). This leads to down-regulation of the PI3K-AKT-mTOR signaling pathway (PubMed:33479206). {ECO:0000269|PubMed:33479206}.
uniprot
proteins
mass_dalton
15758
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="S->A: Reduces phosphorylation. Abolishes phosphorylation and abolishes interaction with C2CD2L; when associated with A-22; A-140 and A-142."; /evidence="ECO:0000269|PubMed:33479206"; MUTAGEN 22; /note="S->A: Reduces phosphorylation. Abolishes phosphorylation and abolishes interaction with C2CD2L; when associated with A-19; A-140 and A-142."; /evidence="ECO:0000269|PubMed:33479206"; MUTAGEN 50; /note="S->N: Reduces alt-RPL36 protein levels. Reduces phosphorylation. Abolishes interaction with C2CD2L."; /evidence="ECO:0000269|PubMed:33479206"; MUTAGEN 73; /note="R->C: No effect on alt-RPL36 protein levels. No effect on phosphorylation. Reduces interaction with C2CD2L."; /evidence="ECO:0000269|PubMed:33479206"; MUTAGEN 93; /note="V->A: Reduces alt-RPL36 protein levels. Reduces phosphorylation. No effect on interaction with C2CD2L."; /evidence="ECO:0000269|PubMed:33479206"; MUTAGEN 98; /note="Q->H: Reduces alt-RPL36 protein levels. Reduces phosphorylation. Reduces interaction with C2CD2L."; /evidence="ECO:0000269|PubMed:33479206"; MUTAGEN 104; /note="Q->H: No effect on alt-RPL36 protein levels. Reduces phosphorylation. Reduces interaction with C2CD2L."; /evidence="ECO:0000269|PubMed:33479206"; MUTAGEN 115; /note="P->A: Reduces alt-RPL36 protein levels. Reduces phosphorylation. Reduces interaction with C2CD2L."; /evidence="ECO:0000269|PubMed:33479206"; MUTAGEN 118; /note="E->K: No effect on alt-RPL36 protein levels. Reduces phosphorylation. No effect on interaction with C2CD2L."; /evidence="ECO:0000269|PubMed:33479206"; MUTAGEN 140; /note="S->A: Reduces phosphorylation. Abolishes phosphorylation and abolishes interaction with C2CD2L; when associated with A-19; A-22 and A-142."; /evidence="ECO:0000269|PubMed:33479206"; MUTAGEN 142; /note="S->A: Reduces phosphorylation. Abolishes phosphorylation and abolishes interaction with C2CD2L; when associated with A-19; A-22 and A-140."; /evidence="ECO:0000269|PubMed:33479206
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is regulated by cytosolic calcium levels (PubMed:33479206). Increased calcium levels reduce phosphorylation at Ser-19, Ser-140 and Ser-142 but increase phosphorylation at Ser-22 (PubMed:33479206). {ECO:0000269|PubMed:33479206}.
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
33479206
uniprot
proteins
sequence_length
148
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:33479206}.
uniprot
proteins