RASGRP2
entrez
10235
canonical
uniprot
Q7LDG7
canonical
ensembl
ENSG00000068831
resolver
ensp
ENSP00000338864
resolver
ensp
ENSP00000366717
resolver
ensp
ENSP00000377953
resolver
ensp
ENSP00000562330
resolver
ensp
ENSP00000562334
resolver
ensp
ENSP00000562336
resolver
ensp
ENSP00000562339
resolver
ensp
ENSP00000562342
resolver
ensp
ENSP00000626398
resolver
genesymbol
RASGRP2
resolver
genesymbol_syn
CDC25L
resolver
genesymbol_syn
MCG7
resolver
hgnc
HGNC:9879
resolver
uniprot
A6NDC7
resolver
uniprot
B3KV60
resolver
uniprot
O00538
resolver
uniprot
Q9UL65
resolver
uniprot_entry
B3KV60_HUMAN
resolver
uniprot_entry
GRP2_HUMAN
resolver
uniprot_sec
A6NDC7
resolver
uniprot_sec
O00538
resolver
uniprot_sec
Q9UL65
resolver
activity_regulation
ACTIVITY REGULATION: Isoform 1 and isoform 2 are differently regulated by calcium and DAG. {ECO:0000269|PubMed:10918068}.
uniprot
proteins
amino_acid_sequence
MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMVSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTVEDGVFDIHL
uniprot
proteins
disease_involvement
DISEASE: Bleeding disorder, platelet-type, 18 (BDPLT18) [MIM:615888]: A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. {ECO:0000269|PubMed:24958846, ECO:0000269|PubMed:27235135, ECO:0000269|PubMed:28726538, ECO:0000269|PubMed:28762304}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:14702343, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:24958846, ECO:0000269|PubMed:27235135}.
uniprot
proteins
mass_dalton
69248
uniprot
proteins
post_translational_modification
PTM: Isoform 2 is palmitoylated and myristoylated. {ECO:0000269|PubMed:10918068}.
uniprot
proteins
protein_family
RASGRP family
uniprot
proteins
pubmed
10918068
uniprot
proteins
pubmed
11278453
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14702343
uniprot
proteins
pubmed
14988412
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17576779
uniprot
proteins
pubmed
17702895
uniprot
proteins
pubmed
19064721
uniprot
proteins
pubmed
19234460
uniprot
proteins
pubmed
19234463
uniprot
proteins
pubmed
23908768
uniprot
proteins
pubmed
24958846
uniprot
proteins
pubmed
27235135
uniprot
proteins
pubmed
28726538
uniprot
proteins
pubmed
28762304
uniprot
proteins
pubmed
9341881
uniprot
proteins
pubmed
9789079
uniprot
proteins
sequence_length
609
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Synapse, synaptosome {ECO:0000305}. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Found both in the cytosol and associated with membranes. Isoform 2 mainly localizes to the cell membrane. Enriched at juxtamembrane areas and membrane ruffles through association with F-actin. Localizes to the cell bodies and axons of striatal neurons (By similarity). {ECO:0000250}.
uniprot
proteins