FUT2
entrez
2524
canonical
uniprot
Q10981
canonical
ensembl
ENSG00000176920
resolver
ensp
ENSP00000387498
resolver
ensp
ENSP00000430227
resolver
ensp
ENSP00000630810
resolver
ensp
ENSP00000630811
resolver
enst
ENST00000425340
resolver
enst
ENST00000522966
resolver
enst
ENST00000960751
resolver
enst
ENST00000960752
resolver
genesymbol
FUT2
resolver
genesymbol_syn
SEC2
resolver
hgnc
HGNC:4013
resolver
uniprot
A8K2L2
resolver
uniprot
Q0VAG5
resolver
uniprot
Q14338
resolver
uniprot
Q5D0G2
resolver
uniprot_entry
A8K2L2_HUMAN
resolver
uniprot_entry
FUT2_HUMAN
resolver
uniprot_sec
Q0VAG5
resolver
uniprot_sec
Q14338
resolver
uniprot_sec
Q5D0G2
resolver
amino_acid_sequence
MLVVQMPFSFPMAHFILFVFTVSTIFHVQQRLAKIQAMWELPVQIPVLASTSKALGPSQLRGMWTINAIGRLGNQMGEYATLYALAKMNGRPAFIPAQMHSTLAPIFRITLPVLHSATASRIPWQNYHLNDWMEEEYRHIPGEYVRFTGYPCSWTFYHHLRQEILQEFTLHDHVREEAQKFLRGLQVNGSRPGTFVGVHVRRGDYVHVMPKVWKGVVADRRYLQQALDWFRARYSSLIFVVTSNGMAWCRENIDTSHGDVVFAGDGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLTGGDTIYLANYTLPDSPFLKIFKPEAAFLPEWTGIAADLSPLLKH
uniprot
proteins
ec_number
2.4.1.344
uniprot
proteins
ec_number
2.4.1.69
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:12692541, PubMed:7876235, PubMed:8018146). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (By similarity). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:22068912, PubMed:24733310). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235). {ECO:0000250|UniProtKB:Q9JL27, ECO:0000269|PubMed:12692541, ECO:0000269|PubMed:21625510, ECO:0000269|PubMed:22068912, ECO:0000269|PubMed:24733310, ECO:0000269|PubMed:7876235, ECO:0000269|PubMed:8018146}.
uniprot
proteins
mass_dalton
39017
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:7876235}.
uniprot
proteins
protein_family
Glycosyltransferase 11 family
uniprot
proteins
pubmed
12692541
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18776911
uniprot
proteins
pubmed
20506485
uniprot
proteins
pubmed
21625510
uniprot
proteins
pubmed
22068912
uniprot
proteins
pubmed
24733310
uniprot
proteins
pubmed
7876235
uniprot
proteins
pubmed
8018146
uniprot
proteins
pubmed
8621666
uniprot
proteins
pubmed
8755920
uniprot
proteins
pubmed
9219535
uniprot
proteins
pubmed
9760207
uniprot
proteins
sequence_length
343
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
uniprot
proteins
transmembrane_region
TRANSMEM 15..28; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins