Adk
entrez
25368
canonical
uniprot
Q64640
canonical
ensembl
ENSRNOG00000012325
resolver
ensp
ENSRNOP00000016709
resolver
ensp
ENSRNOP00000073983
resolver
enst
ENSRNOT00000016709
resolver
enst
ENSRNOT00000080274
resolver
genesymbol
Adk
resolver
uniprot
A0A0G2JSL8
resolver
uniprot
A0A0G2K6X9
resolver
uniprot
O09162
resolver
uniprot
Q642G1
resolver
uniprot_entry
A0A0G2JSL8_RAT
resolver
uniprot_entry
A0A0G2K6X9_RAT
resolver
uniprot_entry
ADK_RAT
resolver
uniprot_sec
O09162
resolver
uniprot_sec
Q642G1
resolver
amino_acid_sequence
MAAADEPKPKKLKVEAPEALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSMKVAQWMIQEPHRAATFFGCIGIDKFGEILKSKAADAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDLENNWMLVEKARVYYIAGFFLTVSPESVLKVARYAAENNRTFTLNLSAPFISQFFKEALMEVMPYVDILFGNETEAATFAREQGFETKDIKEIARKTQALPKVNSKRQRTVIFTQGRDDTIVATGNDVTAFPVLDQNQEEIVDTNGAGDAFVGGFLSQLVSNKPLTECIRAGHYAASVIIRRTGCTFPEKPDFH
uniprot
proteins
ec_number
2.7.1.-
uniprot
proteins
ec_number
2.7.1.20
uniprot
proteins
function
FUNCTION: Adenosine kinase that mediates the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner: catalyzes phosphorylation of both unmodified and modified adenosines (PubMed:9070863). Plays a key role in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification (By similarity). Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction (By similarity). Catalyzes the phosphorylation of the free cytosolic methylated adenosine nucleotides N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A) into adenosine monophosphate (AMP) intermediates that are further detoxified by MAPDA/ADAL (By similarity). {ECO:0000250|UniProtKB:P55263, ECO:0000269|PubMed:9070863}.
uniprot
proteins
mass_dalton
40134
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1. {ECO:0000305|PubMed:9070863}.
uniprot
proteins
protein_family
Carbohydrate kinase PfkB family
uniprot
proteins
pubmed
11833783
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8917457
uniprot
proteins
pubmed
9070863
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P55263}.
uniprot
proteins