Slc14a2
entrez
27411
canonical
uniprot
Q8R4T9
canonical
ensembl
ENSMUSG00000024552
resolver
ensp
ENSMUSP00000025434
resolver
ensp
ENSMUSP00000126416
resolver
ensp
ENSMUSP00000157851
resolver
ensp
ENSMUSP00000157855
resolver
ensp
ENSMUSP00000158141
resolver
enst
ENSMUST00000025434
resolver
enst
ENSMUST00000163367
resolver
enst
ENSMUST00000235389
resolver
enst
ENSMUST00000237290
resolver
enst
ENSMUST00000237674
resolver
genesymbol
Slc14a2
resolver
genesymbol_syn
Ut2
resolver
uniprot
A0A0R4J213
resolver
uniprot
A0A494BA18
resolver
uniprot
A0A494BAL3
resolver
uniprot
B2RWS5
resolver
uniprot
G5E849
resolver
uniprot
Q8BMD1
resolver
uniprot
Q8K5D0
resolver
uniprot
Q9ES04
resolver
uniprot
Q9ES05
resolver
uniprot_entry
A0A0R4J213_MOUSE
resolver
uniprot_entry
A0A494BA18_MOUSE
resolver
uniprot_entry
A0A494BAL3_MOUSE
resolver
uniprot_entry
G5E849_MOUSE
resolver
uniprot_entry
Q8BMD1_MOUSE
resolver
uniprot_entry
UT2_MOUSE
resolver
uniprot_sec
B2RWS5
resolver
uniprot_sec
Q8K5D0
resolver
uniprot_sec
Q9ES04
resolver
uniprot_sec
Q9ES05
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform A1]: Inhibited by phloretin (PubMed:12217874). Activated by forskolin, 3-isobutyl-1-methylxanthine (IBMX) and cAMP (PubMed:12217874). {ECO:0000269|PubMed:12217874}.; ACTIVITY REGULATION: [Isoform A2]: Inhibited by phloretin. {ECO:0000269|PubMed:12217874}.; ACTIVITY REGULATION: [Isoform A3]: Inhibited by phloretin (PubMed:11029290). Activated by forskolin, 3-isobutyl-1-methylxanthine (IBMX) and cAMP (PubMed:12217874). {ECO:0000269|PubMed:11029290, ECO:0000269|PubMed:12217874}.; ACTIVITY REGULATION: [Isoform A5]: Inhibited by phloretin. {ECO:0000269|PubMed:11029290}.
uniprot
proteins
amino_acid_sequence
MSDHHPLKEMSDSNSSPLLPEPLSSRYKLYESELSSPTWPSSSQDTHPALPLLEMPEEKDLRSSDEDSHIVKIEKPNERNKRRESEVSRRASAGRGGFSLFQAVSYLTGDMKECKNWLKDKPLVLQFLDWVLRGAAQVMFVNNPISGLIIFIGLLIQNPWWTIAGTLGTVASTLAALALSQDRSAIASGLHGYNGMLVGLLMAVFSEKLDYYWWLLFPVTFTSMACPIISSALSTIFAKWDLPVFTLPFNIALTLYLAATGHYNLFFPTTLIKPASAAPNITWTEIEMPLLLQTIPVGVGQVYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYLGLWSYNCVLSCIAIGGMFYALTWQTHLLALVCALFCAYMGAALSNTMAVVGVPSGTWAFCLSTLTFLLLTSNNTGIYKLPLSKVTYPEANRIYFLTVRRSEEEKSPNGGSGEQSHGSGQWKAEESSETVLPRRRSVFHIEWSSIRRRSKVFGKGEHQERQTKEPLPCPYRKPTVELFDLDTMEESTEIKVEANTARTSWIQSSMVAGGKRVSKALSYITGEMKECGEGLKDKSPVFQFLDWVLRGMSQVMFVNNPLSGILIVLGLFVQNPWWAISGCLGTVMSTLTALILSQDKSAIAAGLHGYNGVLVGLLMAVFSDKGNYYWWLLLPVIVMSMTCPILSSALSTVFSKWDLPVFTLPFNIAVTLYLAATGHHNLFFPTTLLQPATTTPNITWSDIQVSLLLRAIPVGIGQVYGCDNPWTGGIFLVALFISSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTSNNPAIYKLPLSKVTYPEANRIYFLSQEKNRRASTITKYQAYDVS
uniprot
proteins
function
FUNCTION: [Isoform A1]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. {ECO:0000269|PubMed:12217874}.; FUNCTION: [Isoform A2]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. {ECO:0000269|PubMed:12217874}.; FUNCTION: [Isoform A3]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. {ECO:0000269|PubMed:11029290, ECO:0000269|PubMed:12217874}.; FUNCTION: [Isoform A5]: Mediates the transport of urea driven by a concentration gradient across the cell membrane (PubMed:11029290). Implicated in the urea movement across the blood-testis barrier and does not translocate water (PubMed:11029290). {ECO:0000269|PubMed:11029290}.
uniprot
proteins
mass_dalton
102047
uniprot
proteins
protein_family
Urea transporter family
uniprot
proteins
pubmed
11029290
uniprot
proteins
pubmed
11880324
uniprot
proteins
pubmed
12217874
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
930
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:12217874}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:12217874}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 145..165; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 242..262; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 280..300; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 350..372; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 401..421; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 610..630; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 648..668; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 676..696; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 705..725; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 774..794; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 813..833; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 842..862; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 864..884; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins