Sdk2
entrez
237979
canonical
uniprot
Q6V4S5
canonical
ensembl
ENSMUSG00000041592
resolver
ensp
ENSMUSP00000038972
resolver
genesymbol
Sdk2
resolver
genesymbol_syn
Kiaa1514
resolver
uniprot
Q3TTK1
resolver
uniprot
Q5U5W7
resolver
uniprot
Q6ZPP2
resolver
uniprot_entry
SDK2_MOUSE
resolver
uniprot_sec
Q3TTK1
resolver
uniprot_sec
Q5U5W7
resolver
uniprot_sec
Q6ZPP2
resolver
amino_acid_sequence
MFSSMWRLPLWTLLALHRIHSAGAQDDVPPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTRFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKRQSVNHGEAAVIRAPRISSFPRPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLAVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTMECVANARPLIKLHIVWKKDGAPLSSGISDYNRRLTIANPTVSDAGYYECEAMLRSSSVAPVTRGAYLSVLEPPQFVREPERHITAEMEKVVDIPCRAKGVPPPSITWYKDAALVEVGKLTRFKQRSDGGLQISGLLPDDTGMLQCFAHNAAGEAQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTLLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTVRYVWEKDGATLAVETNPRIRLDRNGSLHISQTWSGDIGTYTCRVLSAGGNDSRNAHLRVRQLPHAPEHPVATLSTVERRAINLTWAKPFDGNSPLMRYVLEMSENNAPWTILLASVDPEATSVMVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPAQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSSPQLVRTHEDVPGPVGHLSFNDILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGAPTNLGISNIGPRSVTLQFRPGYDGKTSISRWVVEAQVGVIGEGEEWLLIYQLGNEPDARSMEVPDLNPFTYYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDIAPANVTLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYGRSDGHGKTLSHTVQDRVEREYTIEDLEEWTEYRVQVQAFNAIGSGPWSQAVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEIPEADRNGLVLGYKVRYKEKDSDSQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNATTANTATVEVLAPSARQYMATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSKPVVQQEDVKARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASAFTVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPSEDKINGILLGFRIRYRELLYDGLRGFTLRGINNPGAKWAELTSLYSMRNLTRPSLTQYELDNLSKHRRYEIRMSIYNAVGEGPLSPPQEVFVGEAVPTAAPQNVAIHSATATQLDVTWEPPPLDNQNGDIQGYKIYFWEVQRRNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTRGQTQQAAPSAPGSVKFSELTTTSVNVSWDAPQFPNGPLEGYRLVYEPCTPVDGVSKIVTVDVKGNSPLWLKVKDLAEGMTYRFRIKAKTFTYGPEIEANITTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVTSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKASPFYEEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYSKKTDSGGNTKSGALGHGEMLSLDESSFPALELNNRRLSVKNSFCRKNGLYTRSPPRPSPGSLHYSDEDVTKYNDLIPAESSSLTEKPSEISDSQGSDSEYEVDTNTQKAHSFVNHYISDPTYYNSWRRQQKGISRAQAYSYTESDSGEPDHVTVPNSNSTQQGSLFRPKASRTPTPQNPPNPQSQQSTLYRPPSSLAPGSRAPIAGFSSFV
uniprot
proteins
function
FUNCTION: Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion (PubMed:26287463). Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion (PubMed:26287463). Promotes synaptic connectivity via homophilic interactions (PubMed:26287463). {ECO:0000269|PubMed:26287463}.
uniprot
proteins
mass_dalton
239902
uniprot
proteins
mutagenesis
MUTAGEN 2174..2176; /note="Missing: Abolishes localization to synapses and induces diffuse expression in photoreceptor cells."; /evidence="ECO:0000269|PubMed:20219992
uniprot
proteins
protein_family
Sidekick family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15213259
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15703275
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20219992
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26287463
uniprot
proteins
sequence_length
2176
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8AV57}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8AV57}. Synapse {ECO:0000269|PubMed:20219992, ECO:0000305|PubMed:26287463}.
uniprot
proteins
transmembrane_region
TRANSMEM 1937..1957; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins