Psmc4
entrez
117262
canonical
uniprot
Q63570
canonical
ensembl
ENSRNOG00000018994
resolver
ensembl
ENSRNOG00055033590
resolver
ensembl
ENSRNOG00060027595
resolver
ensembl
ENSRNOG00065034009
resolver
ensp
ENSRNOP00000025819
resolver
ensp
ENSRNOP00055047909
resolver
ensp
ENSRNOP00060039837
resolver
ensp
ENSRNOP00065048048
resolver
enst
ENSRNOT00000025819
resolver
enst
ENSRNOT00055058069
resolver
enst
ENSRNOT00060047893
resolver
enst
ENSRNOT00065058399
resolver
genesymbol
Psmc4
resolver
genesymbol_syn
Tbp7
resolver
uniprot_entry
PRS6B_RAT
resolver
amino_acid_sequence
MEEIGILVEKIQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000250|UniProtKB:P43686}.
uniprot
proteins
mass_dalton
47408
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17292836
uniprot
proteins
pubmed
8607789
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P43686}. Nucleus {ECO:0000250|UniProtKB:P43686}.
uniprot
proteins