NBR1
entrez
4077
canonical
uniprot
Q14596
canonical
ensembl
ENSG00000188554
resolver
ensp
ENSP00000343479
resolver
ensp
ENSP00000437545
resolver
ensp
ENSP00000466667
resolver
ensp
ENSP00000467816
resolver
ensp
ENSP00000598897
resolver
ensp
ENSP00000625715
resolver
ensp
ENSP00000625719
resolver
ensp
ENSP00000625720
resolver
ensp
ENSP00000625726
resolver
enst
ENST00000542611
resolver
genesymbol
NBR1
resolver
genesymbol_syn
1A13B
resolver
genesymbol_syn
KIAA0049
resolver
genesymbol_syn
M17S2
resolver
hgnc
HGNC:6746
resolver
uniprot
B7Z5R6
resolver
uniprot
F6WLH9
resolver
uniprot
Q13173
resolver
uniprot
Q15026
resolver
uniprot
Q5J7Q8
resolver
uniprot
Q96GB6
resolver
uniprot
Q9NRF7
resolver
uniprot_entry
B7Z5R6_HUMAN
resolver
uniprot_entry
F6WLH9_HUMAN
resolver
uniprot_entry
NBR1_HUMAN
resolver
uniprot_sec
Q13173
resolver
uniprot_sec
Q15026
resolver
uniprot_sec
Q5J7Q8
resolver
uniprot_sec
Q96GB6
resolver
uniprot_sec
Q9NRF7
resolver
amino_acid_sequence
MEPQVTLNVTFKNEIQSFLVSDPENTTWADIEAMVKVSFDLNTIQIKYLDEENEEVSINSQGEYEEALKMAVKQGNQLQMQVHEGHHVVDEAPPPVVGAKRLAARAGKKPLAHYSSLVRVLGSDMKTPEDPAVQSFPLVPCDTDQPQDKPPDWFTSYLETFREQVVNETVEKLEQKLHEKLVLQNPSLGSCPSEVSMPTSEETLFLPENQFSWHIACNNCQRRIVGVRYQCSLCPSYNICEDCEAGPYGHDTNHVLLKLRRPVVGSSEPFCHSKYSTPRLPAALEQVRLQKQVDKNFLKAEKQRLRAEKKQRKAEVKELKKQLKLHRKIHLWNSIHGLQSPKSPLGRPESLLQSNTLMLPLQPCTSVMPMLSAAFVDENLPDGTHLQPGTKFIKHWRMKNTGNVKWSADTKLKFMWGNLTLASTEKKDVLVPCLKAGHVGVVSVEFIAPALEGTYTSHWRLSHKGQQFGPRVWCSIIVDPFPSEESPDNIEKGMISSSKTDDLTCQQEETFLLAKEERQLGEVTEQTEGTAACIPQKAKNVASERELYIPSVDLLTAQDLLSFELLDINIVQELERVPHNTPVDVTPCMSPLPHDSPLIEKPGLGQIEEENEGAGFKALPDSMVSVKRKAENIASVEEAEEDLSGTQFVCETVIRSLTLDAAPDHNPPCRQKSLQMTFALPEGPLGNEKEEIIHIAEEEAVMEEEEDEEDEEEEDELKDEVQSQSSASSEDYIIILPECFDTSRPLGDSMYSSALSQPGLERGAEGKPGVEAGQEPAEAGERLPGGENQPQEHSISDILTTSQTLETVPLIPEVVELPPSLPRSSPCVHHHGSPGVDLPVTIPEVSSVPDQIRGEPRGSSGLVNSRQKSYDHSRHHHGSSIAGGLVKGALSVAASAYKALFAGPPVTAQPIISEDQTAALMAHLFEMGFCDRQLNLRLLKKHNYNILQVVTELLQLNNNDWYSQRY
uniprot
proteins
function
FUNCTION: Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133, PubMed:38169523). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). {ECO:0000250|UniProtKB:P97432, ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24692539, ECO:0000269|PubMed:24879152, ECO:0000269|PubMed:33577621, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:35914352, ECO:0000269|PubMed:38169523}.
uniprot
proteins
mass_dalton
107413
uniprot
proteins
mutagenesis
MUTAGEN 12; /note="K->A: No effect on interaction with SQSTM1."; /evidence="ECO:0000269|PubMed:12813044"; MUTAGEN 50; /note="D->R: Loss of interaction with SQSTM1."; /evidence="ECO:0000269|PubMed:12813044, ECO:0000269|PubMed:19250911"; MUTAGEN 586; /note="T->A: Loss of phosphorylation by GSK3A."; /evidence="ECO:0000269|PubMed:24879152"; MUTAGEN 732; /note="Y->A: Loss of interaction ATG8 family proteins."; /evidence="ECO:0000269|PubMed:19250911"; MUTAGEN 926; /note="E->A: About 3-fold weaker interaction with ubiquitin than WT."; /evidence="ECO:0000269|PubMed:24692539"; MUTAGEN 928; /note="G->A: About 2-fold weaker interaction with ubiquitin than WT."; /evidence="ECO:0000269|PubMed:24692539"; MUTAGEN 929; /note="F->A: Complete loss of interaction with ubiquitin."; /evidence="ECO:0000269|PubMed:24692539
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Cleaved by S.pyogenes SpeB protease; leading to its degradation (PubMed:24331465). Degradation by SpeB prevents autophagy, promoting to S.pyogenes intracellular replication (PubMed:24331465). {ECO:0000269|PubMed:24331465}.; PTM: Phosphorylated by GSK3A; this phosphorylation inhibits NBR1 involvement in the formation of ubiquitinated protein aggregates. {ECO:0000269|PubMed:24879152}.
uniprot
proteins
pubmed
11179671
uniprot
proteins
pubmed
12813044
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15802564
uniprot
proteins
pubmed
16376336
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19250911
uniprot
proteins
pubmed
19427866
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24331465
uniprot
proteins
pubmed
24692539
uniprot
proteins
pubmed
24879152
uniprot
proteins
pubmed
33226137
uniprot
proteins
pubmed
33577621
uniprot
proteins
pubmed
34471133
uniprot
proteins
pubmed
35914352
uniprot
proteins
pubmed
38169523
uniprot
proteins
pubmed
7581362
uniprot
proteins
pubmed
7584044
uniprot
proteins
pubmed
8069304
uniprot
proteins
sequence_length
966
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19427866, ECO:0000269|PubMed:35914352, ECO:0000269|PubMed:38169523}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:24879152}. Lysosome {ECO:0000269|PubMed:19250911}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q501R9}. Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (PubMed:19250911). {ECO:0000250|UniProtKB:Q501R9, ECO:0000269|PubMed:19250911}.
uniprot
proteins