Acvr1
entrez
11477
canonical
uniprot
P37172
canonical
ensembl
ENSMUSG00000026836
resolver
ensp
ENSMUSP00000056784
resolver
ensp
ENSMUSP00000088453
resolver
ensp
ENSMUSP00000108218
resolver
ensp
ENSMUSP00000108220
resolver
ensp
ENSMUSP00000343537
resolver
enst
ENSMUST00000056376
resolver
enst
ENSMUST00000090935
resolver
enst
ENSMUST00000112599
resolver
enst
ENSMUST00000112601
resolver
genesymbol
Acvr1
resolver
genesymbol_syn
Acvrlk2
resolver
genesymbol_syn
Tgfb1
resolver
uniprot
Q3UDH5
resolver
uniprot
Q91VF1
resolver
uniprot_entry
ACVR1_MOUSE
resolver
uniprot_sec
Q3UDH5
resolver
uniprot_sec
Q91VF1
resolver
amino_acid_sequence
MVDGVMILPVLMMMAFPSPSVEDEKPKVNQKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACILGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
uniprot
proteins
ec_number
2.7.11.30
uniprot
proteins
function
FUNCTION: Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation (PubMed:10479450, PubMed:15531373, PubMed:21945937). As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A ors ACVR2B. Upon binding of ligands such as BMP7 or BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor. Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs (By similarity) (PubMed:10479450, PubMed:15531373, PubMed:21945937, PubMed:25413979). May promote the expression of HAMP, potentially via its interaction with BMP6 (PubMed:31800957). {ECO:0000250|UniProtKB:Q04771, ECO:0000269|PubMed:10479450, ECO:0000269|PubMed:15531373, ECO:0000269|PubMed:21945937, ECO:0000269|PubMed:25413979, ECO:0000269|PubMed:31800957}.
uniprot
proteins
mass_dalton
57226
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TGFB receptor subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
10479450
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15531373
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21945937
uniprot
proteins
pubmed
25413979
uniprot
proteins
pubmed
31800957
uniprot
proteins
pubmed
8388127
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 124..146; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins