Nek3
entrez
23954
canonical
uniprot
Q9R0A5
canonical
ensembl
ENSMUSG00000031478
resolver
ensp
ENSMUSP00000033865
resolver
ensp
ENSMUSP00000106358
resolver
ensp
ENSMUSP00000136876
resolver
ensp
ENSMUSP00000274095
resolver
enst
ENSMUST00000033865
resolver
enst
ENSMUST00000110730
resolver
enst
ENSMUST00000178324
resolver
genesymbol
Nek3
resolver
uniprot
E9QLM2
resolver
uniprot
F8WGD4
resolver
uniprot
Q9Z0X9
resolver
uniprot_entry
F8WGD4_MOUSE
resolver
uniprot_entry
NEK3_MOUSE
resolver
uniprot_sec
E9QLM2
resolver
uniprot_sec
Q9Z0X9
resolver
amino_acid_sequence
MDNYTVLRVIGQGSFGRALLVLQESSNQTFAMKEIRLLKSDTQTSRKEAVLLAKMKHPNIVAFKESFEAEGYLYIVMEYCDGGDLMQRIKQQKGKLFPEDTILNWFIQICLGVNHIHKRRVLHRDIKSKNVFLTHNGKVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCALKHPFQANSWKNLILKICQGPIHPLPALYSCKLQGLVKQMLKRNPSHRPSATTLLCRGSLAPLVPKCLPPQIIREYGEQILDEIKISTPKNMKKQDSNRVRRALGEANSASMQEEERGRKCSHTELESTGTTPAGNALERAARGNPESGNPQEHGRHTSPASPHRPWWERHGPSSNVEALEKASILTSSFTAEDDRGGSVIKYEENARRQWVREPPEALLSMLKDADLSQAFQTYTIYRPGAEGFLKGPLSEDTASDSVDGDLDSVMLDPERFEPRLDEEDTDFEEDNENPDWVSELKKHVGYGDGPGGQLLGERA
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. {ECO:0000269|PubMed:19509051}.
uniprot
proteins
mass_dalton
57464
uniprot
proteins
mutagenesis
MUTAGEN 477; /note="T->A: Distorted neuronal morphology with disturbed polarity and deacetylation of microtubules."; /evidence="ECO:0000269|PubMed:19509051
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-477 regulates its catalytic activity. {ECO:0000269|PubMed:19509051}.
uniprot
proteins
protein_family
NEK Ser/Thr protein kinase family
uniprot
proteins
protein_family
NIMA subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10224116
uniprot
proteins
pubmed
10393247
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19509051
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
511
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19509051}. Cell projection, axon {ECO:0000269|PubMed:19509051}.
uniprot
proteins