METTL10
entrez
399818
canonical
uniprot
Q5JPI9
canonical
ensembl
ENSG00000203791
resolver
ensp
ENSP00000357829
resolver
ensp
ENSP00000498289
resolver
genesymbol
EEF1AKMT2
resolver
genesymbol
METTL10
resolver
genesymbol_syn
C10orf138
resolver
genesymbol_syn
METTL10
resolver
hgnc
HGNC:33787
resolver
uniprot
A0A494BZY7
resolver
uniprot
A8MPY7
resolver
uniprot
Q8TC28
resolver
uniprot_entry
EFMT2_HUMAN
resolver
uniprot_entry
Q8TC28_HUMAN
resolver
uniprot_sec
A0A494BZY7
resolver
uniprot_sec
A8MPY7
resolver
amino_acid_sequence
MSSGADGGGGAAVAARSDKGSPGEDGFVPSALGTREHWDAVYERELQTFREYGDTGEIWFGEESMNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELAKFGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNLSTQLSGFHICIDKGTFDAISLNPDNAIEKRKQYVKSLSRVLKVKGFFLITSCNWTKEELLNEFSEGFELLEELPTPKFSFGGRSGNSVAALVFQKM
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: [Isoform 2]: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. {ECO:0000255|HAMAP-Rule:MF_03188, ECO:0000269|PubMed:25144183, ECO:0000269|PubMed:38199565}.
uniprot
proteins
mass_dalton
25904
uniprot
proteins
mutagenesis
MUTAGEN 85..91; /note="DIGTGNG->AIATANA: Highly reduces methylation activity toward EEF1A1."; /evidence="ECO:0000269|PubMed:25144183"; MUTAGEN 218; /note="F->A: No effect on elongation factor 1-alpha."; /evidence="ECO:0000269|PubMed:38199565"; MUTAGEN 220; /note="F->A: Reduces elongation factor 1-alpha 'Lys-318' methylation."; /evidence="ECO:0000269|PubMed:38199565
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
EFM4 family
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25144183
uniprot
proteins
pubmed
38199565
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03188, ECO:0000269|PubMed:25144183}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03188, ECO:0000269|PubMed:25144183}.
uniprot
proteins