AATF
entrez
26574
canonical
uniprot
Q9NY61
canonical
ensembl
ENSG00000275700
resolver
ensembl
ENSG00000276072
resolver
ensp
ENSP00000477848
resolver
ensp
ENSP00000481894
resolver
ensp
ENSP00000506264
resolver
ensp
ENSP00000506655
resolver
ensp
ENSP00000684850
resolver
enst
ENST00000619387
resolver
enst
ENST00000620004
resolver
enst
ENST00000680340
resolver
enst
ENST00000680579
resolver
genesymbol
AATF
resolver
genesymbol_syn
CHE1
resolver
genesymbol_syn
DED
resolver
hgnc
HGNC:19235
resolver
uniprot
A0A7P0TAR0
resolver
uniprot
A0A7P0TBG4
resolver
uniprot
A6NCJ6
resolver
uniprot
B3KQ26
resolver
uniprot
Q9P0A4
resolver
uniprot
Q9UNX5
resolver
uniprot_entry
A0A7P0TAR0_HUMAN
resolver
uniprot_entry
A0A7P0TBG4_HUMAN
resolver
uniprot_entry
AATF_HUMAN
resolver
uniprot_sec
A6NCJ6
resolver
uniprot_sec
B3KQ26
resolver
uniprot_sec
Q9P0A4
resolver
uniprot_sec
Q9UNX5
resolver
amino_acid_sequence
MAGPQPLALQLEQLLNPRPSEADPEADPEEATAARVIDRFDEGEDGEGDFLVVGSIRKLASASLLDTDKRYCGKTTSRKAWNEDHWEQTLPGSSDEEISDEEGSGDEDSEGLGLEEYDEDDLGAAEEQECGDHRESKKSRSHSAKTPGFSVQSISDFEKFTKGMDDLGSSEEEEDEESGMEEGDDAEDSQGESEEDRAGDRNSEDDGVVMTFSSVKVSEEVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPLFKDKGGPEFSSALKNSHKALKALLRSLVGLQEELLFQYPDTRYLVDGTKPNAGSEEISSEDDELVEEKKQQRRRVPAKRKLEMEDYPSFMAKRFADFTVYRNRTLQKWHDKTKLASGKLGKGFGAFERSILTQIDHILMDKERLLRRTQTKRSVYRVLGKPEPAAQPVPESLPGEPEILPQAPANAHLKDLDEEIFDDDDFYHQLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIHKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTTMNDDARTELYRSLFGQLHPPDEGHGD
uniprot
proteins
function
FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}.
uniprot
proteins
mass_dalton
63133
uniprot
proteins
post_translational_modification
PTM: Hyperphosphorylated during the G1/S phase transition.
uniprot
proteins
protein_family
AATF family
uniprot
proteins
pubmed
10783144
uniprot
proteins
pubmed
11027528
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
12450794
uniprot
proteins
pubmed
12847090
uniprot
proteins
pubmed
14627703
uniprot
proteins
pubmed
14697667
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15207272
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
34516797
uniprot
proteins
sequence_length
560
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:34516797}.
uniprot
proteins