CDKAL1
entrez
54901
canonical
uniprot
Q5VV42
canonical
ensembl
ENSG00000145996
resolver
ensp
ENSP00000274695
resolver
ensp
ENSP00000549628
resolver
ensp
ENSP00000584266
resolver
ensp
ENSP00000779594
resolver
ensp
ENSP00000793617
resolver
genesymbol
CDKAL1
resolver
hgnc
HGNC:21050
resolver
uniprot
A8K6S0
resolver
uniprot
Q6P385
resolver
uniprot
Q6ZR27
resolver
uniprot
Q9NXB3
resolver
uniprot_entry
CDKAL_HUMAN
resolver
uniprot_sec
A8K6S0
resolver
uniprot_sec
Q6P385
resolver
uniprot_sec
Q6ZR27
resolver
uniprot_sec
Q9NXB3
resolver
amino_acid_sequence
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSHTSAASQCDSASSRMVLPMPRLHQDCALRMSVGLALLGLLFAFFVKVYN
uniprot
proteins
disease_involvement
DISEASE: Type 2 diabetes mellitus (T2D) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269|PubMed:17460697, ECO:0000269|PubMed:17463246}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.8.4.5
uniprot
proteins
function
FUNCTION: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. {ECO:0000250|UniProtKB:Q91WE6}.
uniprot
proteins
mass_dalton
65111
uniprot
proteins
protein_family
CDKAL1 subfamily
uniprot
proteins
protein_family
Methylthiotransferase family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17460697
uniprot
proteins
pubmed
17463246
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23048041
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
579
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23048041}; Single-pass membrane protein {ECO:0000255}. Note=Is a tail-anchored protein that exploits the TCR40 pathway for insertion into the endoplasmic reticulum. {ECO:0000269|PubMed:23048041}.
uniprot
proteins
transmembrane_region
TRANSMEM 556..578; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins