EBF1
entrez
1879
canonical
uniprot
Q9UH73
canonical
ensembl
ENSG00000164330
resolver
ensp
ENSP00000322898
resolver
ensp
ENSP00000370029
resolver
ensp
ENSP00000428020
resolver
ensp
ENSP00000543173
resolver
genesymbol
EBF1
resolver
genesymbol_syn
COE1
resolver
genesymbol_syn
EBF
resolver
hgnc
HGNC:3126
resolver
uniprot
B4E2U8
resolver
uniprot
Q8IW11
resolver
uniprot_entry
B4E2U8_HUMAN
resolver
uniprot_entry
COE1_HUMAN
resolver
uniprot_sec
Q8IW11
resolver
amino_acid_sequence
MFGIQESIQRSGSSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSEKTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTPSYLEHATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQLPALANTSVHAGMMGVNSFSGQLAVNVSEASQATNQGFTRNSSSVSPHGYVPSTTPQQTNYNSVTTSMNGYGSAAMSNLGGSPTFLNGSAANSPYAIVPSSPTMASSTSLPSNCSSSSGIFSFSPANMVSAVKQKSAFAPVVRPQTSPPPTCTSTNGNSLQAISGMIVPPM
uniprot
proteins
function
FUNCTION: Key pioneer transcription factor of B-cell specification and commitment (PubMed:27807034). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity). {ECO:0000250|UniProtKB:Q07802, ECO:0000269|PubMed:27807034}.; FUNCTION: (Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells (PubMed:28968461). In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency (PubMed:26819314). {ECO:0000269|PubMed:26819314, ECO:0000269|PubMed:28968461}.
uniprot
proteins
mass_dalton
64464
uniprot
proteins
mutagenesis
MUTAGEN 240; /note="H->A: Impaired EBF1-mediated cell differentiation and gene expression mostly without changing EBF1 occupancy."; /evidence="ECO:0000269|PubMed:27807034
uniprot
proteins
protein_family
COE family
uniprot
proteins
pubmed
10942392
uniprot
proteins
pubmed
14630787
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20592035
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
26819314
uniprot
proteins
pubmed
27807034
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28968461
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins