Tmem47
entrez
192216
canonical
uniprot
Q9JJG6
canonical
ensembl
ENSMUSG00000025666
resolver
ensp
ENSMUSP00000026760
resolver
genesymbol
Tmem47
resolver
genesymbol_syn
Tm4sf10
resolver
uniprot
B1AUN5
resolver
uniprot
Q3TS34
resolver
uniprot
Q3UZL4
resolver
uniprot
Q8C0H5
resolver
uniprot_entry
TMM47_MOUSE
resolver
uniprot_sec
B1AUN5
resolver
uniprot_sec
Q3TS34
resolver
uniprot_sec
Q3UZL4
resolver
uniprot_sec
Q8C0H5
resolver
amino_acid_sequence
MASAGSGMEEVRVSVLTPLKLVGLVCIFLALCLDLGAVLSPAWVTADHQYYLSLWESCRKPANLDIWHCESTLGSDWQIATLALLLGGAAIILIAFLVGLISICVGSRRRFYRPVAVMLFAAVVLQVCSLVLYPIKFIETVSLKIYHEFNWGYGLAWGATIFSFGGAILYCLNPKNYEDYY
uniprot
proteins
function
FUNCTION: Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B (PubMed:26990309). During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (PubMed:21881001). {ECO:0000269|PubMed:21881001, ECO:0000269|PubMed:26990309}.
uniprot
proteins
mass_dalton
19995
uniprot
proteins
protein_family
TMEM47 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17195181
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21881001
uniprot
proteins
pubmed
26990309
uniprot
proteins
sequence_length
181
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction {ECO:0000269|PubMed:17195181, ECO:0000269|PubMed:26990309}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9XSV3}. Note=In undifferentiated cultured podocytes localizes to the perinuclear region and translocates to the cell membrane after Cadherin appearance at cell-cell contacts. Upon differentiation of cultured podocytes, protein disappears from cell contacts and expression ceases. Re-expressed upon induced podocyte injury. Colocalizes with FYB1 at cell-cell contacts in podocytes. {ECO:0000269|PubMed:17195181, ECO:0000269|PubMed:21881001}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 83..103; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 152..172; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins