Cd37
entrez
12493
canonical
uniprot
Q61470
canonical
ensembl
ENSMUSG00000030798
resolver
ensp
ENSMUSP00000033063
resolver
ensp
ENSMUSP00000096061
resolver
ensp
ENSMUSP00000147818
resolver
enst
ENSMUST00000033063
resolver
enst
ENSMUST00000098461
resolver
genesymbol
Cd37
resolver
uniprot
F8WH24
resolver
uniprot
Q3U429
resolver
uniprot
Q4FK35
resolver
uniprot_entry
CD37_MOUSE
resolver
uniprot_entry
F8WH24_MOUSE
resolver
uniprot_entry
Q3U429_MOUSE
resolver
uniprot_entry
Q4FK35_MOUSE
resolver
amino_acid_sequence
MSAQESCLSLIKYFLFVFNLFFFVLGGLIFCFGTWILIDKTSFVSFVGLSFVPLQTWSKVLAVSGVLTMALALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRVRLERRVQELVLRTIQSYRTNPDETAAEESWDYAQFQLRCCGWQSPRDWNKAQMLKANESEEPFVPCSCYNSTATNDSTVFDKLFFSQLSRLGPRAKLRQTADICALPAKAHIYREGCAQSLQKWLHNNIISIVGICLGVGLLELGFMTLSIFLCRNLDHVYDRLARYR
uniprot
proteins
function
FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (PubMed:10891477). Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B (By similarity). Plays an essential role for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT (PubMed:23150881). Also plays a role in the migration of dendritic cells and neutrophils to draining lymph nodes, as well as in their integrin-mediated adhesion (PubMed:23420539, PubMed:26566675). Negatively regulates IL-6 responses through direct interaction with SOCS3 thereby preventing constitutive IL-6 signaling (By similarity). Alternatively, inhibition of IL-6 signaling can also occur via interaction and stabilization of DECTIN1/CLEC7A at the cell membrane to inhibit its ability to promote the production of IL-6 (By similarity). {ECO:0000250|UniProtKB:P11049, ECO:0000269|PubMed:10891477, ECO:0000269|PubMed:23150881, ECO:0000269|PubMed:23420539}.
uniprot
proteins
mass_dalton
31852
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated; leading to activation of downstream signaling pathways. {ECO:0000250|UniProtKB:P11049}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
10891477
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23150881
uniprot
proteins
pubmed
23420539
uniprot
proteins
pubmed
26566675
uniprot
proteins
pubmed
26784544
uniprot
proteins
pubmed
8845018
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P11049}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P11049}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 60..74; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 86..111; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 242..266; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins