Pfkl
entrez
25741
canonical
uniprot
P30835
canonical
ensembl
ENSRNOG00000001214
resolver
ensembl
ENSRNOG00055022053
resolver
ensembl
ENSRNOG00060022867
resolver
ensembl
ENSRNOG00065026528
resolver
ensp
ENSRNOP00000001625
resolver
ensp
ENSRNOP00000100786
resolver
ensp
ENSRNOP00055030942
resolver
ensp
ENSRNOP00060032789
resolver
ensp
ENSRNOP00065037593
resolver
enst
ENSRNOT00055037901
resolver
enst
ENSRNOT00060039638
resolver
enst
ENSRNOT00065045822
resolver
genesymbol
Pfkl
resolver
genesymbol_syn
Pfk-l
resolver
uniprot_entry
PFKAL_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate. GlcNAcylation by OGT overcomes allosteric regulation (By similarity). {ECO:0000255|HAMAP-Rule:MF_03184}.
uniprot
proteins
amino_acid_sequence
MATVDLEKLRMSGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKPANWLSVSNIIQLGGTIIGSARCKAFTTREGRLAAAYNLLQHGITNLCVIGGDGSLTGANIFRNEWGSLLEELVKEGKISESTAQNYAHLSIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRHGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRVLSSKMGMEAVMALLEATPDTPACVVSLSGNQSVRLPLMECVQVTKDVQKAMDEKRFDEAIQLRGRSFENNWKIYKLLAHQKVSKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISEGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKPHLEAIVENLRTYNIHALLVIGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKANVEHMTEKMKTDIQRGLVLRNEKCHEHYTTEFLYNLYSSEGRGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWMSEKLRDVYRKGRVFANAPDSACVIGLRKKVVAFSSVTELKKETDFEHRMPREQWWLNLRLMLKMLAHYRISMADYVSGELEHVTRRTLSIDKGF
uniprot
proteins
ec_number
2.7.1.11
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). {ECO:0000250|UniProtKB:P12382, ECO:0000255|HAMAP-Rule:MF_03184}.
uniprot
proteins
mass_dalton
85339
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. {ECO:0000255|HAMAP-Rule:MF_03184}.
uniprot
proteins
post_translational_modification
PTM: GlcNAcylation at Ser-529 by OGT decreases enzyme activity, leading to redirect glucose flux through the oxidative pentose phosphate pathway. Glycosylation is stimulated by both hypoxia and glucose deprivation (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
ATP-dependent PFK group I subfamily
uniprot
proteins
protein_family
Eukaryotic two domain clade 'E' sub-subfamily
uniprot
proteins
protein_family
Phosphofructokinase type A (PFKA) family
uniprot
proteins
pubmed
1836995
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
780
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}.
uniprot
proteins