Mfn1
entrez
67414
canonical
uniprot
Q811U4
canonical
ensembl
ENSMUSG00000027668
resolver
ensp
ENSMUSP00000088801
resolver
ensp
ENSMUSP00000113251
resolver
enst
ENSMUST00000091257
resolver
enst
ENSMUST00000118286
resolver
genesymbol
Mfn1
resolver
uniprot
Q3URC4
resolver
uniprot
Q811D5
resolver
uniprot
Q8CEY6
resolver
uniprot
Q99M10
resolver
uniprot
Q9D395
resolver
uniprot_entry
MFN1_MOUSE
resolver
uniprot_sec
Q3URC4
resolver
uniprot_sec
Q811D5
resolver
uniprot_sec
Q8CEY6
resolver
uniprot_sec
Q99M10
resolver
uniprot_sec
Q9D395
resolver
amino_acid_sequence
MAETVSPLKHFVLAKKAITAIFGQLLEFVTEGSHFVEATYRNPELDRIASEDDLVEIQGYRNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKAKCALLRDDLVLVDSPGTDVTTELDIWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVVSPSEARNRIFFVSAKEVLNSRKHKAQGMPEGGGALAEGFQARLQEFQNFEQTFEECISQSAVKTKFEQHTIRAKQILDTVKNILDSVNVAAAEKRVYSMEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPTPSVLKVYKSELNKHIEDGMGRNLADRCTNEVNASILQSQQEIIENLKPLLPAGIQNKLHTLIPCKKFDLSYDLNCHKLCSDFQEDIVFRFSLGWSSLVHRFLGSTNAQRVLLGLSEPIFQVPRSLASTPTAPSNPAAPDNAAQEELMITLITGLASLTSRTSMGIIVVGGVIWKTVGWKLISVTLSMYGALYLYERLTWTTRAKERAFKQQFVNYATEKLQMIVSFTSANCSHQVQQEMATTFARLCQQVDVTQKHLEEEIARLSKEIDQLEKIQNNSKLLRNKAVQLESELENFSKQFLHPSSGES
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12527753, PubMed:15297672, PubMed:23921378, PubMed:24513856). Membrane clustering requires GTPase activity (By similarity). It may involve a major rearrangement of the coiled coil domains (PubMed:15297672). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12527753). Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity (By similarity). {ECO:0000250|UniProtKB:Q8IWA4, ECO:0000269|PubMed:12527753, ECO:0000269|PubMed:15297672, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:24513856}.
uniprot
proteins
mass_dalton
83726
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MARCHF5 (By similarity). When mitochondria are depolarized and dysfunctional, it is ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that contains FBXO7 and PRKN. Ubiquitinated by non-degradative ubiquitin by PRKN, promoting mitochondrial fusion; deubiquitination by USP30 inhibits mitochondrial fusion (PubMed:24513856). {ECO:0000250|UniProtKB:Q8IWA4, ECO:0000269|PubMed:24513856}.
uniprot
proteins
protein_family
Dynamin/Fzo/YdjA family
uniprot
proteins
protein_family
Mitofusin subfamily
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
11950885
uniprot
proteins
pubmed
12527753
uniprot
proteins
pubmed
12759376
uniprot
proteins
pubmed
15297672
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23620051
uniprot
proteins
pubmed
23921378
uniprot
proteins
pubmed
24513856
uniprot
proteins
sequence_length
741
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:12759376}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 585..605; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 609..629; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins