Spib
entrez
499146
canonical
uniprot
Q5EBA3
canonical
ensembl
ENSRNOG00000019660
resolver
ensp
ENSRNOP00000026599
resolver
ensp
ENSRNOP00000091947
resolver
genesymbol
Spib
resolver
uniprot_entry
SPIB_RAT
resolver
amino_acid_sequence
MLALEAAQLDGPHLSCLQYPEGVFYDLDSCKSFSYPDSDGGPDSTWGWTEAPPAPAIAAYEAFDPAATAAFAHTQAVQLCYGHGPSPSTYSPVGTLDPAPSLEASGPGLQVYPSEDFTSQTLGSLAYAPYPSPVLSEEEDILLDSPALEVSDSESDEALLAGSEGRGSEAGARKKLRLYQFLLELLLRGDMRECVWWVEPGAGVFQFSSKHKELLARRWGQQKGNRKRMTYQKLARALRNYAKTGEIRKVKRKLTYQFDSALLPAARRA
uniprot
proteins
function
FUNCTION: Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. Required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
29400
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q01892}.
uniprot
proteins