RAB25
entrez
57111
canonical
uniprot
P57735
canonical
ensembl
ENSG00000132698
resolver
ensp
ENSP00000354376
resolver
enst
ENST00000361084
resolver
genesymbol
RAB25
resolver
genesymbol_syn
CATX8
resolver
hgnc
HGNC:18238
resolver
uniprot
Q5VYA2
resolver
uniprot
Q8NG24
resolver
uniprot
Q96GB1
resolver
uniprot
Q9BT12
resolver
uniprot_entry
RAB25_HUMAN
resolver
uniprot_sec
Q5VYA2
resolver
uniprot_sec
Q8NG24
resolver
uniprot_sec
Q96GB1
resolver
uniprot_sec
Q9BT12
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP (Probable). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation (Probable). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MGNGTEEDYNFVFKVVLIGESGVGKTNLLSRFTRNEFSHDSRTTIGVEFSTRTVMLGTAAVKAQIWDTAGLERYRAITSAYYRGAVGALLVFDLTKHQTYAVVERWLKELYDHAEATIVVMLVGNKSDLSQAREVPTEEARMFAENNGLLFLETSALDSTNVELAFETVLKEIFAKVSKQRQNSIRTNAITLGSAQAGQEPGPGEKRACCISL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB25 regulates epithelial cell differentiation, proliferation and survival, thereby playing key roles in tumorigenesis (PubMed:17925226). Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway (By similarity). Together with MYO5B regulates transcytosis (By similarity). {ECO:0000250|UniProtKB:E2RQ15, ECO:0000250|UniProtKB:P46629, ECO:0000250|UniProtKB:P61106, ECO:0000250|UniProtKB:Q9WTL2, ECO:0000269|PubMed:17925226}.
uniprot
proteins
mass_dalton
23496
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11495908
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15502842
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17925226
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
26032412
uniprot
proteins
pubmed
28017832
uniprot
proteins
sequence_length
213
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:17925226}. Cell projection, pseudopodium membrane {ECO:0000269|PubMed:17925226}. Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips. Colocalizes with RAB11A in subapical vesicles (By similarity). {ECO:0000250|UniProtKB:P46629, ECO:0000269|PubMed:17925226}.
uniprot
proteins