DENND2B
entrez
6764
canonical
uniprot
P78524
canonical
ensembl
ENSG00000166444
resolver
ensp
ENSP00000319678
resolver
ensp
ENSP00000432887
resolver
ensp
ENSP00000433528
resolver
ensp
ENSP00000436802
resolver
ensp
ENSP00000528013
resolver
ensp
ENSP00000528018
resolver
ensp
ENSP00000528019
resolver
ensp
ENSP00000528024
resolver
ensp
ENSP00000623087
resolver
ensp
ENSP00000623089
resolver
ensp
ENSP00000623091
resolver
genesymbol
DENND2B
resolver
genesymbol_syn
HTS1
resolver
genesymbol_syn
ST5
resolver
hgnc
HGNC:11350
resolver
uniprot
B2R6X7
resolver
uniprot
B3KXQ6
resolver
uniprot
P78523
resolver
uniprot
Q16492
resolver
uniprot
Q7KYY2
resolver
uniprot
Q7KZ12
resolver
uniprot
Q8NE12
resolver
uniprot
Q9BQQ6
resolver
uniprot_entry
DEN2B_HUMAN
resolver
uniprot_sec
B2R6X7
resolver
uniprot_sec
B3KXQ6
resolver
uniprot_sec
P78523
resolver
uniprot_sec
Q16492
resolver
uniprot_sec
Q7KYY2
resolver
uniprot_sec
Q7KZ12
resolver
uniprot_sec
Q8NE12
resolver
uniprot_sec
Q9BQQ6
resolver
amino_acid_sequence
MTMTANKNSSITHGAGGTKAPRGTLSRSQSVSPPPVLSPPRSPIYPLSDSETSACRYPSHSSSRVLLKDRHPPAPSPQNPQDPSPDTSPPTCPFKTASFGYLDRSPSACKRDAQKESVQGAAQDVAGVAACLPLAQSTPFPGPAAGPRGVLLTRTGTRAHSLGIREKISAWEGRREASPRMSMCGEKREGSGSEWAASEGCPSLGCPSVVPSPCSSEKTFDFKGLRRMSRTFSECSYPETEEEGEALPVRDSFYRLEKRLGRSEPSAFLRGHGSRKESSAVLSRIQKIEQVLKEQPGRGLPQLPSSCYSVDRGKRKTGTLGSLEEPAGGASVSAGSRAVGVAGVAGEAGPPPEREGSGSTKPGTPGNSPSSQRLPSKSSLDPAVNPVPKPKRTFEYEADKNPKSKPSNGLPPSPTPAAPPPLPSTPAPPVTRRPKKDMRGHRKSQSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSKSTLEENAYEDIVGDLPKENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSPPTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDRFKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN
uniprot
proteins
function
FUNCTION: [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}.
uniprot
proteins
mass_dalton
126485
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation decreases ITSN1 binding. {ECO:0000269|PubMed:29030480}.
uniprot
proteins
pubmed
10229203
uniprot
proteins
pubmed
11528127
uniprot
proteins
pubmed
1390339
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20937701
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29030480
uniprot
proteins
pubmed
8972856
uniprot
proteins
pubmed
9632734
uniprot
proteins
sequence_length
1137
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cell cortex {ECO:0000269|PubMed:29030480}. Cell membrane {ECO:0000269|PubMed:29030480}. Recycling endosome {ECO:0000269|PubMed:29030480}. Note=Colocalizes with RAB13 and ITSN1 at cytoplasmic vesicles that are most likely recycling endosomes. Colocalizes with the cortical actin cytoskeleton. {ECO:0000269|PubMed:29030480}.
uniprot
proteins