Sucnr1
entrez
408199
canonical
uniprot
Q6IYF9
canonical
ensembl
ENSRNOG00000014039
resolver
ensp
ENSRNOP00000018767
resolver
enst
ENSRNOT00000018767
resolver
genesymbol
Sucnr1
resolver
genesymbol_syn
Gpr91
resolver
uniprot_entry
SUCR1_RAT
resolver
amino_acid_sequence
MAQNLSCENWLALENILKKYYLSAFYGIEFIVGMLGNFTVVFGYLFCMKNWNSSNVYLFNLSISDLAFLCTLPMLIRSYATGNWTYGDVLCISNRYVLHANLYTSILFLTFISIDRYLLMKFPFREHILQKKEFAILISLAVWVLVTLEVLPMLTFITSTPIEKGDSCVDYASSGNPKYSLIYSLCLTLLGFLIPLSVMCFFYYKMVVFLKKRSQQQATVLSLNKPLRLVVLAVVIFSVLFTPYHIMRNVRIASRLDSWPQGCSQKAIKCLYILTRPLAFLNSAVNPIFYFLVGDHFRDMLFSKLRQYFKSLTSFRL
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated (PubMed:15141213). Succinate-SUCNR1 signaling serves as a link between metabolic stress, inflammation and energy homeostasisn (By similarity). In macrophages, plays a range of immune-regulatory roles. During inflammation, succinate-SUCNR1 signaling may act as an anti-inflammatory mediator or boost inflammation depending on the inflammatory status of cells (By similarity). Hyperpolarizes M2 macrophages versus M1 phenotype through Gq signaling by regulating the transcription of genes involved in immune function (By similarity). In activated M1 macrophages, plays a pro-inflammatory role in response to LPS (By similarity). Expressed in dendritic cells, where it is involved in the sensing of immunological danger and enhances immunity. Mediates succinate triggered intracelleular calcium mobilization, induces migratory responses and acts in synergy with Toll-like receptor ligands for the production of proinflammatory cytokines as well as an enhancement of antigen-specific activation of helper T cells (By similarity). In the small intestine, mediates the activation of tuft cells by dietary succinate and triggers type 2 immunity. In adipocytes, plays an important role in the control of energy metabolism. In response to succinate, controls leptin expression in an AMPK-JNK-CEBPA-dependent as well as circadian clock-regulated manner. In muscle tissue, is expressed in non-muscle cells and coordinates muscle remodeling in response to the succinate produced during exercise training in a paracrine manner (By similarity). In retina, acts as a mediator of vessel growth during retinal development. In response to succinate, regulates the production of angiogenic factors, including VEGF, by retinal ganglion neurons (PubMed:18836459). {ECO:0000250|UniProtKB:Q99MT6, ECO:0000250|UniProtKB:Q9BXA5, ECO:0000269|PubMed:15141213, ECO:0000269|PubMed:18836459}.
uniprot
proteins
mass_dalton
36679
uniprot
proteins
mutagenesis
MUTAGEN 18; /note="K->E: Humanized SUCNR1; when associated with N-269."; /evidence="ECO:0000269|PubMed:31645725"; MUTAGEN 269; /note="K->N: Humanized SUCNR1; when associated with N-269."; /evidence="ECO:0000269|PubMed:31645725
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15141213
uniprot
proteins
pubmed
18836459
uniprot
proteins
pubmed
31645725
uniprot
proteins
pubmed
32856916
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BXA5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BXA5}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..48; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 56..76; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 134..154; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 182..202; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 227..247; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins