RBM23
entrez
55147
canonical
uniprot
Q86U06
canonical
ensembl
ENSG00000100461
resolver
ensp
ENSP00000339220
resolver
ensp
ENSP00000352956
resolver
ensp
ENSP00000382806
resolver
ensp
ENSP00000438504
resolver
ensp
ENSP00000631295
resolver
ensp
ENSP00000631296
resolver
ensp
ENSP00000631297
resolver
enst
ENST00000542016
resolver
genesymbol
RBM23
resolver
genesymbol_syn
RNPC4
resolver
hgnc
HGNC:20155
resolver
uniprot
A0A0S2Z5D9
resolver
uniprot
A0A0S2Z5I1
resolver
uniprot
A0A0S2Z5J3
resolver
uniprot
B7Z8M4
resolver
uniprot
D3DS32
resolver
uniprot
G3XAP0
resolver
uniprot
Q8ND16
resolver
uniprot
Q8TB88
resolver
uniprot
Q8WY40
resolver
uniprot
Q9BUJ1
resolver
uniprot
Q9NVV7
resolver
uniprot_entry
A0A0S2Z5D9_HUMAN
resolver
uniprot_entry
A0A0S2Z5I1_HUMAN
resolver
uniprot_entry
A0A0S2Z5J3_HUMAN
resolver
uniprot_entry
B7Z8M4_HUMAN
resolver
uniprot_entry
G3XAP0_HUMAN
resolver
uniprot_entry
RBM23_HUMAN
resolver
uniprot_sec
D3DS32
resolver
uniprot_sec
Q8ND16
resolver
uniprot_sec
Q8TB88
resolver
uniprot_sec
Q8WY40
resolver
uniprot_sec
Q9BUJ1
resolver
uniprot_sec
Q9NVV7
resolver
amino_acid_sequence
MASDDFDIVIEAMLEAPYKKEEDEQQRKEVKKDYPSNTTSSTSNSGNETSGSSTIGETSKKKRSRSHNKSRDRKRSRSRDRDRYRRRNSRSRSPGRQCRHRSRSWDRRHGSESRSRDHRREDRVHYRSPPLATGYRYGHSKSPHFREKSPVREPVDNLSPEERDARTVFCMQLAARIRPRDLEDFFSAVGKVRDVRIISDRNSRRSKGIAYVEFCEIQSVPLAIGLTGQRLLGVPIIVQASQAEKNRLAAMANNLQKGNGGPMRLYVGSLHFNITEDMLRGIFEPFGKIDNIVLMKDSDTGRSKGYGFITFSDSECARRALEQLNGFELAGRPMRVGHVTERLDGGTDITFPDGDQELDLGSAGGRFQLMAKLAEGAGIQLPSTAAAAAAAAAQAAALQLNGAVPLGALNPAALTALSPALNLASQCFQLSSLFTPQTM
uniprot
proteins
function
FUNCTION: RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor (PubMed:15694343). Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity (PubMed:15694343). {ECO:0000269|PubMed:15694343}.
uniprot
proteins
mass_dalton
48731
uniprot
proteins
mutagenesis
MUTAGEN 169..173; /note="FCMQL->ACMQA: In M1; abolished ability to regulate steroid hormone receptor-mediated transcription, without affecting the pre-mRNA splicing factor activity."; /evidence="ECO:0000269|PubMed:15694343"; MUTAGEN 266..270; /note="YVGSL->AVGSA: In M2; reduced pre-mRNA splicing factor activity without affecting steroid hormone receptor-mediated transcription."; /evidence="ECO:0000269|PubMed:15694343"; MUTAGEN 369..373; /note="LMAKL->AMAKA: In M3; reduced pre-mRNA splicing factor activity without affecting steroid hormone receptor-mediated transcription."; /evidence="ECO:0000269|PubMed:15694343
uniprot
proteins
post_translational_modification
PTM: Aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, promote ubiquitination and subsequent degradation by the DCX(DCAF15) complex (PubMed:31686031, PubMed:31693891, PubMed:31819272). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM23 (PubMed:31686031, PubMed:31819272). {ECO:0000269|PubMed:31686031, ECO:0000269|PubMed:31693891, ECO:0000269|PubMed:31819272}.
uniprot
proteins
protein_family
Splicing factor SR family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
15694343
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
31686031
uniprot
proteins
pubmed
31693891
uniprot
proteins
pubmed
31819272
uniprot
proteins
sequence_length
439
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins