Rraga
entrez
117044
canonical
uniprot
Q63486
canonical
genesymbol
Rraga
resolver
uniprot_entry
RRAGA_RAT
resolver
activity_regulation
ACTIVITY REGULATION: The activation of GTP-binding proteins is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). The Ragulator complex functions as a GEF and promotes the active GTP-bound form. The GATOR1 complex functions as a GAP and stimulates RRAGA GTPase activity to turn it into its inactive GDP-bound form, preventing mTORC1 recruitment and activation. {ECO:0000250|UniProtKB:Q7L523}.
uniprot
proteins
amino_acid_sequence
MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQCKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKHSLLMR
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagA/RRAGA is in its active form when GTP-bound RagA/RRAGA forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagA/RRAGA heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF signaling pathway leading to induction of cell death. {ECO:0000250|UniProtKB:Q7L523}.
uniprot
proteins
mass_dalton
36566
uniprot
proteins
post_translational_modification
PTM: Polybiquitinated via 'Lys-63'-linked polyubiquitination by RNF152 in response to amino acid starvation: polyubiquitination of the GDP-bound inactive form by RNF152 promotes RRAGA inactivation and interaction with the GATOR1 complex. This does not affect RRAGA degradation. {ECO:0000250|UniProtKB:Q7L523}.
uniprot
proteins
protein_family
GTR/RAG GTP-binding protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7499430
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7L523}. Nucleus {ECO:0000250|UniProtKB:Q7L523}. Lysosome membrane {ECO:0000250|UniProtKB:Q7L523}. Note=Predominantly cytoplasmic. Recruited to the lysosome surface by the Ragulator complex. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. {ECO:0000250|UniProtKB:Q7L523}.
uniprot
proteins