Grp
entrez
171101
canonical
uniprot
P24393
canonical
ensembl
ENSRNOG00000016999
resolver
ensp
ENSRNOP00000022845
resolver
enst
ENSRNOT00000022845
resolver
genesymbol
Grp
resolver
uniprot
G3V871
resolver
uniprot_entry
GRP_RAT
resolver
uniprot_sec
G3V871
resolver
amino_acid_sequence
MRGSELSLLLLALVLCQAPRGPAAPVSTGAGGGTVLAKMYPRGSHWAVGHLMGKKSTDELPPLYAADRDGLKEQLRGYIRWEEAARNLLGLLEAAGNRSHQPPQDQPLGSLQPTWDPEDGSYFSDAQNAKLVDSLLQVLKGKEGTAS
uniprot
proteins
function
FUNCTION: Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (By similarity). Contributes primarily to nonhistaminergic itch sensation (By similarity). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (By similarity). Contributes to the regulation of food intake (PubMed:17208656). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (PubMed:33059246). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). {ECO:0000250|UniProtKB:P63153, ECO:0000250|UniProtKB:Q8R1I2, ECO:0000269|PubMed:17208656, ECO:0000269|PubMed:33059246}.; FUNCTION: [Neuromedin-C]: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation. {ECO:0000250|UniProtKB:Q8R1I2}.
uniprot
proteins
mass_dalton
15702
uniprot
proteins
protein_family
Bombesin/neuromedin-B/ranatensin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17208656
uniprot
proteins
pubmed
26855425
uniprot
proteins
pubmed
2843761
uniprot
proteins
pubmed
33059246
uniprot
proteins
sequence_length
147
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P07492}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:Q863C3}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q8R1I2}. Note=In neurons of the retrotrapezoid nucleus/parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex. {ECO:0000250|UniProtKB:Q8R1I2}.
uniprot
proteins