ANAPC11
entrez
51529
canonical
uniprot
Q9NYG5
canonical
ensembl
ENSG00000141552
resolver
ensp
ENSP00000339695
resolver
ensp
ENSP00000349957
resolver
ensp
ENSP00000376181
resolver
ensp
ENSP00000458143
resolver
ensp
ENSP00000458265
resolver
ensp
ENSP00000459200
resolver
ensp
ENSP00000460064
resolver
ensp
ENSP00000461648
resolver
ensp
ENSP00000463598
resolver
ensp
ENSP00000463640
resolver
ensp
ENSP00000464615
resolver
ensp
ENSP00000758868
resolver
genesymbol
ANAPC11
resolver
hgnc
HGNC:14452
resolver
uniprot
A8MTT2
resolver
uniprot
B7ZW64
resolver
uniprot
Q502X9
resolver
uniprot
Q9BW64
resolver
uniprot
Q9P0R2
resolver
uniprot_entry
APC11_HUMAN
resolver
uniprot_sec
A8MTT2
resolver
uniprot_sec
B7ZW64
resolver
uniprot_sec
Q502X9
resolver
uniprot_sec
Q9BW64
resolver
uniprot_sec
Q9P0R2
resolver
amino_acid_sequence
MKVKIKCWNGVATWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCILKWLHAQQVQQHCPMCRQEWKFKE
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:11739784, PubMed:18485873, PubMed:27120157, PubMed:27509861). Together with ANAPC2, forms the catalytic component of the E3 ubiquitin ligase complex (PubMed:11739784, PubMed:18485873, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:11739784, PubMed:18485873). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (PubMed:27509861). {ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:27120157, ECO:0000269|PubMed:27509861, ECO:0000269|PubMed:29033132}.
uniprot
proteins
mass_dalton
9841
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="C->S: Greatly reduces autoubiquitination activity; in isoform 1."; /evidence="ECO:0000269|PubMed:11739784"; MUTAGEN 26; /note="C->S: Greatly reduces autoubiquitination activity; in isoform 1."; /evidence="ECO:0000269|PubMed:11739784"; MUTAGEN 34; /note="C->S: Slightly reduces autoubiquitination activity; in isoform 1."; /evidence="ECO:0000269|PubMed:11739784"; MUTAGEN 37; /note="C->S: Slightly reduces autoubiquitination activity; in isoform 1."; /evidence="ECO:0000269|PubMed:11739784"; MUTAGEN 44; /note="C->S: Slightly reduces autoubiquitination activity; in isoform 1."; /evidence="ECO:0000269|PubMed:11739784"; MUTAGEN 51; /note="C->S: Greatly reduces autoubiquitination activity; in isoform 1."; /evidence="ECO:0000269|PubMed:11739784"; MUTAGEN 53; /note="H->S: Greatly reduces autoubiquitination activity; in isoform 1."; /evidence="ECO:0000269|PubMed:11739784"; MUTAGEN 56; /note="H->S: Greatly reduces autoubiquitination activity; in isoform 1."; /evidence="ECO:0000269|PubMed:11739784"; MUTAGEN 58; /note="H->S: Slightly reduces autoubiquitination activity; in isoform 1."; /evidence="ECO:0000269|PubMed:11739784"; MUTAGEN 59; /note="C->S: Greatly reduces autoubiquitination activity; in isoform 1."; /evidence="ECO:0000269|PubMed:11739784"; MUTAGEN 73; /note="C->S: Greatly reduces autoubiquitination activity; in isoform 1."; /evidence="ECO:0000269|PubMed:11739784"; MUTAGEN 76; /note="C->S: Greatly reduces autoubiquitination activity; in isoform 1."; /evidence="ECO:0000269|PubMed:11739784
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated.
uniprot
proteins
protein_family
RING-box family
uniprot
proteins
pubmed
10922056
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11573242
uniprot
proteins
pubmed
11739784
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16364912
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18485873
uniprot
proteins
pubmed
25043029
uniprot
proteins
pubmed
26083744
uniprot
proteins
pubmed
27120157
uniprot
proteins
pubmed
27509861
uniprot
proteins
pubmed
29033132
uniprot
proteins
sequence_length
84
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11573242}. Nucleus {ECO:0000269|PubMed:11573242}.
uniprot
proteins