P97691
uniprot
P97691
canonical
amino_acid_sequence
MRTSPRRPLILKRRRLPLPIQNAPSETSEEEAKRSPGQQEPTQAQASQDVAESSSCKFPAGIKIINHPTVPNTQVVAIPNNADIQSIITALTAKGKESGSSGPNKFILISSGGASSHPPDPQSQAQTSTDSKRTELITETLGPKPGAKGVPVPKPPGALPRQRQESCGGEAAGCTLDNSLTNIQWLGKMSSDGLGRCSIKQELEEKENCHLEQNRVKVEAPSRASVSWQDSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRYLTLDQVFKPLEPGSPQSPEHLESQQKRPNPELRRNVTIKTELPLGARRKMKPLLPRVSSYLVPIQFPVNQSLVLQPSVKVPLPLAASLMSSELARHSKRVRIAPKVLLSNEGIAPLPATEPMKEEKPLLGEGLLPLLPIQSIKEEVIQPGEDIPHLERPIKVESPPLEEWPSPCASVKEELSNSWEDSSCSPTPKPKKSYCGLKSPTRCVSEMLVTKRREKREVSRSRRKQHLQPPCLDEPELFFSEDSSTFRPAMEILAESSEPAPQLSCPQEEGGPFKTPIKETLPVSSTPSKSVLSRDPESWRLTPPAKVGGLDFSPVRTPQGAFGPLPDSLGLMELNTTPLKSVPLFDSPRELLNSEAFDLASDPFSSSPPPHLEAKPGSPELQVPSLSANRSLTEGLVLDTMNDSLSKILLDISFPGLEEDPLGPDNINWSQFIPELR
uniprot
proteins
function
FUNCTION: Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2. {ECO:0000250|UniProtKB:Q08050}.
uniprot
proteins
mass_dalton
83672
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators (By similarity). Phosphorylated by GSK3B leading to ubiquitination and proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:Q08050}.
uniprot
proteins
pubmed
9242644
uniprot
proteins
sequence_length
759
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
uniprot
proteins