NFKBIZ
entrez
64332
canonical
uniprot
Q9BYH8
canonical
ensembl
ENSG00000144802
resolver
ensp
ENSP00000325663
resolver
ensp
ENSP00000377618
resolver
genesymbol
NFKBIZ
resolver
genesymbol_syn
IKBZ
resolver
genesymbol_syn
INAP
resolver
genesymbol_syn
MAIL
resolver
hgnc
HGNC:29805
resolver
uniprot
B3KNR2
resolver
uniprot
D3DN54
resolver
uniprot
Q8IUL4
resolver
uniprot
Q8NAZ8
resolver
uniprot_entry
IKBZ_HUMAN
resolver
uniprot_sec
B3KNR2
resolver
uniprot_sec
D3DN54
resolver
uniprot_sec
Q8IUL4
resolver
uniprot_sec
Q8NAZ8
resolver
amino_acid_sequence
MIVDKLLDDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASPPAAAPGACDASCSVLGPSAPGSPGSDSSDFSSASSVSSCGAVESRSRGGARAERQPVEPHMGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVSYSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNIINIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQMIDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSLVSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLPFSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY
uniprot
proteins
function
FUNCTION: Involved in regulation of NF-kappa-B transcription factor complexes (PubMed:16513645, PubMed:16622025). Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation (PubMed:16513645). Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer (PubMed:16513645). Also seems to activate NF-kappa-B-mediated transcription (PubMed:16622025). In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters (PubMed:16622025). Promotes transcription of LCN2 and DEFB4 (PubMed:16622025). Is recruited to IL-6 promoters and activates IL-6 but decreases TNF production in response to LPS (By similarity). Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity). {ECO:0000250|UniProtKB:Q9EST8, ECO:0000269|PubMed:16513645, ECO:0000269|PubMed:16622025}.
uniprot
proteins
mass_dalton
78061
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16513645
uniprot
proteins
pubmed
16622025
uniprot
proteins
pubmed
22814378
uniprot
proteins
sequence_length
718
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16513645}. Note=Aggregated in dot-like structures (PubMed:16513645). Colocalizes with NCOR2 (PubMed:16513645). {ECO:0000269|PubMed:16513645}.
uniprot
proteins