Mcam
entrez
78967
canonical
uniprot
Q9EPF2
canonical
ensembl
ENSRNOG00000007726
resolver
ensembl
ENSRNOG00055018180
resolver
ensembl
ENSRNOG00060018405
resolver
ensembl
ENSRNOG00065022994
resolver
ensp
ENSRNOP00000010464
resolver
ensp
ENSRNOP00000069860
resolver
genesymbol
Mcam
resolver
genesymbol_syn
Muc18
resolver
uniprot
Q6IRH8
resolver
uniprot
Q9ESS8
resolver
uniprot_entry
MUC18_RAT
resolver
uniprot_sec
Q6IRH8
resolver
uniprot_sec
Q9ESS8
resolver
amino_acid_sequence
MGLPRLVCAFLFAACCCCRSATGVPGEEKQPTPTPDPVEVEVGNTALLKCGPAHPSGNFSQVEWFLIHKERQIPIFRVHQGKGQSEPGEYEHRLSLHGPGATLALSQVTPHDDRMFLCKSKQPRPQDHYVQLQVYKAPEEPTIQANVLGIHVDIQELKEVATCVGRNGYPIPQVIWYKNGRPLQEEENRVHIQSSQTVESSGLYTLKSVLSARLVKEDKDAQFYCELSYRLPSGNRMKESKEVTVPVLYPAEKVWVEVEPVGLLKEGDHVKIRCLTDGNPQPHFTINKKNPSTEEMEEESTDENGLLSLEPAQKHHSGVYQCQSLDLETTVMLSSDPLELLVNYVSDVQVDPTAPEVQEGDSLTLTCKAESNQDLEFEWLRDKTGQLLGKGPILQLNNVKREAGGRYLCVASVPSVPGLNRTRRVSVGIFGSPWMAAKERKVWAQENAMLNLSCEASGHPQPTISWNINGSATEWNPDPQTVVSTLNVLVTPELLETGAECTASNSLGSNTTVIILKLVTLTTLTPDSSQTTGLSTPTVSPHSRANSTSTEKKLPQQESKGVVIVAVIVCTLVLAVLGATLYYFYKKGKLPCGRSGKQEITLPPTRKSEFVVEVKSDKLPEEMALLQGSNGDKRAPGDQGEKYIDLRH
uniprot
proteins
function
FUNCTION: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
71327
uniprot
proteins
pubmed
14755543
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
648
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14755543}; Single-pass type I membrane protein {ECO:0000269|PubMed:14755543}. Perikaryon {ECO:0000269|PubMed:14755543}. Note=Detected at the surface of the cell body of motor neurons.
uniprot
proteins
transmembrane_region
TRANSMEM 561..581; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins