DUSP26
entrez
78986
canonical
uniprot
Q9BV47
canonical
ensembl
ENSG00000133878
resolver
ensp
ENSP00000256261
resolver
ensp
ENSP00000524330
resolver
ensp
ENSP00000524336
resolver
genesymbol
DUSP26
resolver
genesymbol_syn
DUSP24
resolver
genesymbol_syn
LDP4
resolver
genesymbol_syn
MKP8
resolver
genesymbol_syn
NATA1
resolver
genesymbol_syn
SKRP3
resolver
hgnc
HGNC:28161
resolver
uniprot
D3DSV8
resolver
uniprot
Q9BTW0
resolver
uniprot_entry
DUS26_HUMAN
resolver
uniprot_sec
D3DSV8
resolver
uniprot_sec
Q9BTW0
resolver
amino_acid_sequence
MCPGNWLWASMTFMARFSRSSSRSPVRTRGTLEEMPTVQHPFLNVFELERLLYTGKTACNHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRGIIPNRGFLRQLLALDRRLRQGLEA
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). {ECO:0000269|PubMed:15796912, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:16924234, ECO:0000269|PubMed:17001450}.
uniprot
proteins
mass_dalton
23946
uniprot
proteins
mutagenesis
MUTAGEN 152; /note="C->A,S: Loss of activity."; /evidence="ECO:0000269|PubMed:15796912, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:16924234
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15796912
uniprot
proteins
pubmed
16581800
uniprot
proteins
pubmed
16924234
uniprot
proteins
pubmed
17001450
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Golgi apparatus.
uniprot
proteins