Ctsk
entrez
29175
canonical
uniprot
O35186
canonical
ensembl
ENSRNOG00000021155
resolver
ensp
ENSRNOP00000111490
resolver
genesymbol
Ctsk
resolver
uniprot_entry
CATK_RAT
resolver
amino_acid_sequence
MWVFKFLLLPVVSFALSPEETLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVHNLEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGNKYWIIKNSWGESWGNKGYVLLARNKNNACGITNLASFPKM
uniprot
proteins
ec_number
3.4.22.38
uniprot
proteins
function
FUNCTION: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. {ECO:0000250|UniProtKB:P43235}.
uniprot
proteins
mass_dalton
36791
uniprot
proteins
protein_family
Peptidase C1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:P43235}. Secreted {ECO:0000250|UniProtKB:P43235}. Apical cell membrane {ECO:0000250|UniProtKB:P43235}; Peripheral membrane protein {ECO:0000250|UniProtKB:P43235}; Extracellular side {ECO:0000250|UniProtKB:P43235}. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells. {ECO:0000250|UniProtKB:P43235}.
uniprot
proteins