Q6MG59
uniprot
Q6MG59
canonical
amino_acid_sequence
MALVLQLLPLLLSKVQGNPEVSLEGNPGDRVNLSCIGVSDPTRWAWAPSFPACKGLSKGRRPILWASSSGTPTVLQHFSGRLRSLDTGIKRLELLLSAGDSGTFFCKGRQENESRTVIQVLGDKAGCRPSGSTHGSEYSKVLIPLLGFGLVLGLGALGLVWWRRSCVPPSHIAPVINAEPQRPLEQDSKISGHLDQEPNLHYADLDHSVLRRHRRMSALVPGDASTVYAVVV
uniprot
proteins
function
FUNCTION: Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner. {ECO:0000250|UniProtKB:D7PDD4, ECO:0000250|UniProtKB:O95866}.
uniprot
proteins
mass_dalton
25083
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:D7PDD4, ECO:0000250|UniProtKB:O95866}.; PTM: May be O-glycosylated. {ECO:0000250|UniProtKB:O95866}.; PTM: Phosphorylated. {ECO:0000250|UniProtKB:D7PDD4}.
uniprot
proteins
pubmed
15060004
uniprot
proteins
sequence_length
232
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O95866}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O95866}.
uniprot
proteins
transmembrane_region
TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins