Pfn4
entrez
382562
canonical
uniprot
Q9D6I3
canonical
ensembl
ENSMUSG00000020639
resolver
ensp
ENSMUSP00000020967
resolver
ensp
ENSMUSP00000136765
resolver
ensp
ENSMUSP00000291458
resolver
ensp
ENSMUSP00000353396
resolver
enst
ENSMUST00000020967
resolver
enst
ENSMUST00000178879
resolver
genesymbol
Pfn4
resolver
uniprot
Q6JEK6
resolver
uniprot_entry
PROF4_MOUSE
resolver
uniprot_sec
Q6JEK6
resolver
amino_acid_sequence
MSHLQNLLLDTLLGTKHVDSAALIKLQEKTLCVTSPGFSVMPSDVRTLLNGFAKNPLLTRREGLYFKEKDYKCVRADDYSLYAKNENTGVVVVKTNMYLVVATYTAGMYPSVCVEATEKLGEYLRKKGN
uniprot
proteins
function
FUNCTION: Involved in male fertility (PubMed:35950913). Required for manchette development and acrosome biogenesis during spermiogenesis (PubMed:35950913). Binds in vitro to phospholipids, including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Contrary to other profilin family members, does not bind to actin in vitro (By similarity). {ECO:0000250|UniProtKB:Q8NHR9, ECO:0000269|PubMed:35950913}.
uniprot
proteins
mass_dalton
14416
uniprot
proteins
protein_family
Profilin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15591451
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
35950913
uniprot
proteins
sequence_length
129
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5IRJ7}. Note=In round spermatids, mainly observed in the acroplaxome. During the progression of spermiogenesis, relocalizes to the developing manchette of spermatids step 8 (S8). Coinciding with the initiation of manchette disassembly in spermatids S14, seen in the cytoplasm subjacent to the disassembling manchette. {ECO:0000250|UniProtKB:Q5IRJ7}.
uniprot
proteins