Slco1a5
entrez
80900
canonical
uniprot
O88397
canonical
ensembl
ENSRNOG00000086993
resolver
ensembl
ENSRNOG00055010368
resolver
ensembl
ENSRNOG00060008757
resolver
ensembl
ENSRNOG00065005666
resolver
ensp
ENSRNOP00000015112
resolver
ensp
ENSRNOP00000048288
resolver
ensp
ENSRNOP00055014168
resolver
ensp
ENSRNOP00060011443
resolver
ensp
ENSRNOP00065006020
resolver
enst
ENSRNOT00000049569
resolver
enst
ENSRNOT00055017603
resolver
enst
ENSRNOT00060014791
resolver
enst
ENSRNOT00065008537
resolver
genesymbol
Slco1a5
resolver
genesymbol_syn
Oatp1a5
resolver
genesymbol_syn
Oatp3
resolver
genesymbol_syn
Slc21a7
resolver
genesymbol_syn
Slco1a2
resolver
uniprot
Q9EQR8
resolver
uniprot_entry
SO1A5_RAT
resolver
uniprot_sec
Q9EQR8
resolver
amino_acid_sequence
MGETEKRVATHEVRCFSKIKMFLLALTWAYVSKSLSGIYMNTMLTQIERQFDIPTSIVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGVGCVIMGLGCFLMSLPHFLMGRYEYETTISPTSNLSSNSFLCMENRSQTLKPTQDPAECIKEMKSLMWIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGILETGKVFGPIVGLLLGSFCASIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLICAGVNILSSIPFFFFPKTLPKEGLQDDVDGTNNDKEEKHREKAKEENRGITKDFLPFMKSLSCNPIYMLLILTSVLQINAFINMFTFLPKYLEQQYGKSTAEVVLLIGVYNLPPICIGYLLIGFIMKKFKITVKKAAYMAFCLSLFEYLLYFLHFMITCDNFPVAGLTASYEGVHHPLYVENKVLADCNRGCSCSTNSWDPVCGDNGLAYMSACLAGCKKSVGTGTNMVFQNCSCIRSSGNSSAVLGLCKKGPECANKLQYFLIMSVIGSFIYSITAIPGYMVLLRCIKPEEKSLGIGLHAFCTRVFAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYNINNFRRIYLVLPAALRGSSYLPALFILILMRKFQFPGEIDSSETELAEMKITVKKSECTDVHGSPQVENDGELKTRL
uniprot
proteins
function
FUNCTION: Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), estrone 3-sulfate and prostaglandin E2, at the plasma membrane (PubMed:11093941, PubMed:19129463, PubMed:9712861). Responsible for intestinal absorption of bile acids (PubMed:11093941). Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine) (PubMed:19129463, PubMed:9712861). Plays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells (By similarity). May also play a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (By similarity). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity). {ECO:0000250|UniProtKB:P46721, ECO:0000250|UniProtKB:Q91YY5, ECO:0000269|PubMed:11093941, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:9712861}.
uniprot
proteins
mass_dalton
74577
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
11093941
uniprot
proteins
pubmed
19129463
uniprot
proteins
pubmed
9712861
uniprot
proteins
sequence_length
670
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P46721}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000250|UniProtKB:P46721}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..40; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 60..80; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 87..111; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 156..184; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 243..267; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 312..333; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 354..377; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 382..405; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 514..536; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 546..571; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 606..623; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins