Oaz3
entrez
53814
canonical
uniprot
Q9R109
canonical
ensembl
ENSMUSG00000028141
resolver
ensp
ENSMUSP00000143080
resolver
enst
ENSMUST00000199678
resolver
genesymbol
Oaz3
resolver
uniprot
Q9WVT4
resolver
uniprot_entry
OAZ3_MOUSE
resolver
uniprot_sec
Q9WVT4
resolver
amino_acid_sequence
MPCNRSRPSLYSLSYIKRGKTRNYLYPFWSPFAYYLYCYKYRITLREKMLPCCYKSITYKEQEDLTLRPHCCLPCSCLPCSCLQCSESLGGLQVGRSTAQEKDHSQLKELYSAGNLTVLSTDPLLHQDPVQLDFHFRLTPHSSAHWHGLLCDHRLFLDIPYQALDQGNRESLTATLEYVEEKTNVDSVFVNFQIDRKDRGALLRAFSYMGFEVVRPDHPALPPWDNVIFMVYPLERDLGHPGQ
uniprot
proteins
function
FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:16916800, PubMed:18508777, PubMed:18973822). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:18062773). Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338). Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (PubMed:24967154). {ECO:0000269|PubMed:16916800, ECO:0000269|PubMed:18062773, ECO:0000269|PubMed:18508777, ECO:0000269|PubMed:18973822, ECO:0000269|PubMed:19449338, ECO:0000269|PubMed:24967154}.
uniprot
proteins
mass_dalton
28228
uniprot
proteins
protein_family
ODC antizyme family
uniprot
proteins
pubmed
10781085
uniprot
proteins
pubmed
10792465
uniprot
proteins
pubmed
15642376
uniprot
proteins
pubmed
16916800
uniprot
proteins
pubmed
18062773
uniprot
proteins
pubmed
18508777
uniprot
proteins
pubmed
18973822
uniprot
proteins
pubmed
19449338
uniprot
proteins
pubmed
24967154
uniprot
proteins
sequence_length
243
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15642376}. Cytoplasm {ECO:0000269|PubMed:15642376}.
uniprot
proteins