Clptm1
entrez
56457
canonical
uniprot
Q8VBZ3
canonical
ensembl
ENSMUSG00000002981
resolver
ensp
ENSMUSP00000051293
resolver
ensp
ENSMUSP00000249483
resolver
enst
ENSMUST00000055242
resolver
genesymbol
Clptm1
resolver
genesymbol_syn
N14
resolver
uniprot
O08708
resolver
uniprot
Q3U758
resolver
uniprot
Q3U823
resolver
uniprot
Q3UG77
resolver
uniprot
Q8VEJ6
resolver
uniprot_entry
CLPT1_MOUSE
resolver
uniprot_sec
O08708
resolver
uniprot_sec
Q3U758
resolver
uniprot_sec
Q3U823
resolver
uniprot_sec
Q3UG77
resolver
uniprot_sec
Q8VEJ6
resolver
amino_acid_sequence
MAAAQEADGAGSAVVAAGGGSSGQVTSNGSIGRDTPAETQPQNPPPQPAPNAWQVIKGVLFRIFIIWAISSWFRRGPSPQDQSGPGGAPRVASRNLFPKDTLMNLHVYISEHEHFTDFNATSALFWEQHDLVYGDWTSGENSDGCYEHFAELDIPQSVQQNGSIYIHVYFTKSGFHPDPRQKALYRRLATVHMSRMINKYKRRRFQKTKNLLTGETEADPEMIKRAEDYGPVEVISHWHPNITINIVDDHTPWVKGSVPPPLDQYVKFDAVSGDYYPIIYFNDYWNLQKDYYPINESLASLPLRVSFCPLSLWRWQLYAAQSTKSPWNFLGDELYEQSDEEQDSVKVALLETSPYLLALTIIVSIVHSVFEFLAFKNDIQFWNSRQSLEGLSVRSVFFGVFQSFVVLLYILDNETNFVVQVSVFIGVLIDLWKITKVMDVRLDREHRVAGIFPCPTFKDKSTYIESSTKVYDDMAFRYLSWILFPLLGCYAVYSLLYLEHKGWYSWVLSMLYGFLLTFGFITMTPQLFINYKLKSVAHLPWRMLTYKALNTFIDDLFAFVIKMPVMYRIGCLRDDVVFFIYLYQRWIYRVDPTRVNEFGMSGEDVSAAASRAQASTAAGALTPAPSTAVSGEDASTVPKATSGACTASQPQEAPPKPAEDKKKD
uniprot
proteins
function
FUNCTION: Involved in GABAergic but not glutamatergic transmission (PubMed:29395912). Binds and traps GABAA receptors in the endoplasmic reticulum (ER) (PubMed:29395912). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors (PubMed:29395912). Altered GABAergic signaling is one among many causes of cleft palate (PubMed:29395912). Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity). Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states (By similarity). May play a role in T-cell development (PubMed:9218588). {ECO:0000250|UniProtKB:O96005, ECO:0000250|UniProtKB:Q96KA5, ECO:0000269|PubMed:29395912, ECO:0000269|PubMed:9218588, ECO:0000303|PubMed:29395912}.
uniprot
proteins
mass_dalton
75291
uniprot
proteins
protein_family
CLPTM1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29395912
uniprot
proteins
pubmed
9218588
uniprot
proteins
pubmed
9828125
uniprot
proteins
sequence_length
664
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305|PubMed:9828125}.
uniprot
proteins
transmembrane_region
TRANSMEM 355..375; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 391..411; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 417..437; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 478..498; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 503..523; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins