Als2cl
entrez
235633
canonical
uniprot
Q60I26
canonical
ensembl
ENSMUSG00000044037
resolver
ensp
ENSMUSP00000081989
resolver
ensp
ENSMUSP00000115718
resolver
ensp
ENSMUSP00000123304
resolver
ensp
ENSMUSP00000193749
resolver
enst
ENSMUST00000084926
resolver
enst
ENSMUST00000130386
resolver
enst
ENSMUST00000155014
resolver
genesymbol
Als2cl
resolver
uniprot
A0A0R4J1X4
resolver
uniprot
Q6KAQ8
resolver
uniprot
Q8C0K7
resolver
uniprot
Q8K468
resolver
uniprot
Q8R222
resolver
uniprot_entry
A0A0R4J1X4_MOUSE
resolver
uniprot_entry
AL2CL_MOUSE
resolver
uniprot_sec
Q6KAQ8
resolver
uniprot_sec
Q8C0K7
resolver
uniprot_sec
Q8K468
resolver
uniprot_sec
Q8R222
resolver
amino_acid_sequence
MSSSEEADLLRLEEVFSTTLARTISLILQPLLLADPEPSDPCGKECLRLLQQLHESAQRLWYVTEQSLLSLRQRLYHPPSKGLEAVLLLSNADHVLQAHMEYIKSYTDCVVAQAFQKVSKKRSEFWRSQRKALRQLLSSGSSEGSVGTTMCQALRQPLSQHVQKYLLLLLSLRDTLDESHPAQELVMHAITLFGNLQSFMGQALDQAVATQALWHSLSSRLRDVLCSPAHRLLQDSQDIPVVVTPLRAERVLLFDDSLVLLQGHNTHTFDLKLVWVKPGQDKCVLHILTPEEEISFCTRDPQGQVVWQWKVTQAVCQALCGKKDFPVLGSGRETSVPPECRCVAYTFCREGRLCQATYDGEWCRAKPHGKGTLKWPDGRNHVGTFYQGLEHGFGICLVPQASEDKFDCYKCHWREGRMCEYGICEYGTDEVYKGYFQAGLRHGFGILESAPQAPQPFRYTGHWERGQRSGYGIEEDRDRGERYIGMWQADQRHGPGVVVTQAGVCYQGTFQGDKMAGPGILLCEDDSLYEGTFTRDLTLLGKGKVTFPNGFTLDGSFSSGTDKGLYTQGVLDTAALPPDPSSTRKRQLGLGTFPVESRWQGVYSPFRDFLRLGCPGEQQEALLGFHTQSSRELRKSQECLCCERSHPEDCVGSMEDTLKELLQHRKPKALQQYLRKALSNSRHPLGQLLRTLMLTFQATYSGIGANKHLQEMAQEEVKQHARELWAAYRGLLKVALQHQGQTLEEENMETRDLQVHGLLLPLILPSFYSELFTLYLLLHEREDGLYSRGITNLSLFPDTKLLEFLDVQKHLWPLKDLKLTSNQRYSLVRDKCFLTATECLQKIITTVHPREKLEVLEKTYGEIEATVSRVLGCKYKLPMDDLLPLLIYVVSRARIQHLGAEIHLIRDMMDPVHTGGLHDFLLTALESCYEHIQKEDMRPHHLPGHWDARDLW
uniprot
proteins
function
FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics (By similarity). {ECO:0000250, ECO:0000269|PubMed:16473597}.
uniprot
proteins
mass_dalton
108146
uniprot
proteins
pubmed
12140191
uniprot
proteins
pubmed
15388334
uniprot
proteins
pubmed
15449545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16473597
uniprot
proteins
pubmed
17239822
uniprot
proteins
sequence_length
952
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15388334, ECO:0000269|PubMed:17239822}. Note=Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells (By similarity). {ECO:0000250}.
uniprot
proteins