SLC25A10
entrez
1468
canonical
uniprot
Q9UBX3
canonical
ensembl
ENSG00000183048
resolver
ensp
ENSP00000328403
resolver
ensp
ENSP00000345580
resolver
ensp
ENSP00000446242
resolver
ensp
ENSP00000790600
resolver
enst
ENST00000545862
resolver
genesymbol
SLC25A10
resolver
genesymbol_syn
DIC
resolver
hgnc
HGNC:10980
resolver
uniprot
A0A0S2Z382
resolver
uniprot
A0A0S2Z3G3
resolver
uniprot
B4E1E9
resolver
uniprot
F6RGN5
resolver
uniprot
Q542Z3
resolver
uniprot
Q96BA1
resolver
uniprot
Q96IP1
resolver
uniprot_entry
A0A0S2Z382_HUMAN
resolver
uniprot_entry
A0A0S2Z3G3_HUMAN
resolver
uniprot_entry
B4E1E9_HUMAN
resolver
uniprot_entry
DIC_HUMAN
resolver
uniprot_entry
F6RGN5_HUMAN
resolver
uniprot_sec
Q542Z3
resolver
uniprot_sec
Q96BA1
resolver
uniprot_sec
Q96IP1
resolver
amino_acid_sequence
MAAEARVSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALRVVRTDGILALYSGLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETAKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGIKVPS
uniprot
proteins
disease_involvement
DISEASE: Mitochondrial DNA depletion syndrome 19 (MTDPS19) [MIM:618972]: An autosomal recessive mitochondrial disorder characterized by progressive and severe epileptic encephalopathy, hypotonia, poor spontaneous movements evolving to spastic quadriparesis and dyskinesias, and respiratory complex I deficiency and mitochondrial DNA depletion in skeletal muscle. {ECO:0000269|PubMed:29211846}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across the mitochondrial inner membrane (PubMed:29211846, PubMed:38780415, PubMed:38937634). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (PubMed:38937634). Does not transport glutathione (By similarity). Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes. Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (By similarity). {ECO:0000250|UniProtKB:Q06143, ECO:0000250|UniProtKB:Q9QZD8, ECO:0000269|PubMed:29211846, ECO:0000269|PubMed:38780415, ECO:0000269|PubMed:38937634}.
uniprot
proteins
mass_dalton
31282
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
10585886
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
29211846
uniprot
proteins
pubmed
38780415
uniprot
proteins
pubmed
38937634
uniprot
proteins
sequence_length
287
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 63..82; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 163..182; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 255..275; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins