Slc7a3
entrez
29485
canonical
uniprot
O08812
canonical
genesymbol
Slc7a3
resolver
genesymbol_syn
Atrc3
resolver
genesymbol_syn
Cat3
resolver
uniprot_entry
CTR3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by high potassium ions-induced membrane depolarization. {ECO:0000269|PubMed:9079705}.
uniprot
proteins
amino_acid_sequence
MLWQALRRFGQKLVRRRLLELGMGETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKEKAGPSIVICFLVAALSSVLAGLCYAEFGARVPGSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISQTLKGTILLNMPHVLAEYPDFFALALVLLLTGLLVLGANESGLVTKVFTGMNLLVLGFVIISGFIKGELRNWKLTKEDYCLTMSESNGTCSLDSMGSGGFMPFGLEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSICFLAYFGVSSALTLMMPYYKLQPESPLPEAFTYVGWEPARYLVAIGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARVHNGTHTPIVATVVSGVIAAFMAFLFELTDLVDLMSIGTLLAYSLVSICVLILRYQPDQEMKNGEEEVELQEERTLEAEKLTVQALFCQVDSIPTLLSGRIVYVCSSLLAVLLTVLCLVLTWWTTPLHSGDPVWVTVVVLILGLILGISGVIWRQPQNRTPLHFKVPVVPLLPLVSIFVNVYLMMQMTADTWARFGVWMLIGFAIYFGYGIQHSVEEVKNHQTLPKTRPQTIDLDLTTSCVHSI
uniprot
proteins
function
FUNCTION: Uniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine (PubMed:9079705). The transport is sodium ions- and pH-independent, moderately trans-stimulated and is mediated by passive diffusion (PubMed:9079705). {ECO:0000269|PubMed:9079705}.
uniprot
proteins
mass_dalton
67525
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q8WY07}.
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
protein_family
Cationic amino acid transporter (CAT) (TC 2.A.3.3) family
uniprot
proteins
pubmed
9079705
uniprot
proteins
sequence_length
619
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..57; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 108..128; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 245..265; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 286..306; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 336..356; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 383..403; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 476..496; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 508..528; /note="Helical; Name=12"; /evidence="ECO:0000255"; TRANSMEM 541..561; /note="Helical; Name=13"; /evidence="ECO:0000255"; TRANSMEM 570..590; /note="Helical; Name=14"; /evidence="ECO:0000255
uniprot
proteins