Lamp5
entrez
76161
canonical
uniprot
Q9D387
canonical
ensembl
ENSMUSG00000027270
resolver
ensp
ENSMUSP00000061180
resolver
ensp
ENSMUSP00000260624
resolver
enst
ENSMUST00000057503
resolver
genesymbol
Lamp5
resolver
uniprot
Q9CXQ4
resolver
uniprot_entry
LAMP5_MOUSE
resolver
uniprot_sec
Q9CXQ4
resolver
amino_acid_sequence
MDLRVRTLLGGDRLRILLMFFHVMVQTVAEQEVENLSGLSTNPEKDIFVVRENGTTCLMAEFAAKFIVPYDVWASNYVDLITEQAEISLTRGAEVKGHCGHNESELEVFWVDHAYTLRMLFVKESHNTSKGPEATWNLNKVHFVYDSSEKTHFKAPVKVNKYIASSHHLSALVTPAGMSYECQAQQTISLASSDPQKTVTMILSAVHIQPFDIISDFVFSEEHKCPVDEQEQLEETLPLILGLILGLVIVITLVIYHIHHKMTANQVQIPRDRSQYKHMG
uniprot
proteins
function
FUNCTION: Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain. {ECO:0000269|PubMed:27272053}.
uniprot
proteins
mass_dalton
31721
uniprot
proteins
mutagenesis
MUTAGEN 276; /note="Y->A: Cell surface localization."; /evidence="ECO:0000269|PubMed:17215451
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:17215451}.
uniprot
proteins
protein_family
LAMP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17215451
uniprot
proteins
pubmed
27272053
uniprot
proteins
sequence_length
280
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17215451}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:17215451}; Single-pass type I membrane protein {ECO:0000269|PubMed:17215451}. Cell projection, dendrite {ECO:0000269|PubMed:17215451}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:27272053}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, growth cone membrane {ECO:0000269|PubMed:17215451}; Single-pass type I membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:17215451}; Single-pass type I membrane protein {ECO:0000269|PubMed:17215451}. Recycling endosome {ECO:0000269|PubMed:17215451}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q9UJQ1}; Single-pass type I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000250|UniProtKB:Q9UJQ1}; Single-pass type I membrane protein {ECO:0000305}. Note=Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:17215451). Colocalizes with UNC93B1 in large endosomal intracellular vesicles (By similarity). Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides (By similarity). Associates with cortical membranes (By similarity). Localizes mostly in cytoplasmic vesicles of neuronal cell body (PubMed:17215451). Localizes to synaptic vesicles in a subset of GABAergic neurons (PubMed:27272053). {ECO:0000250|UniProtKB:Q9UJQ1, ECO:0000269|PubMed:27272053}.
uniprot
proteins
transmembrane_region
TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins