Trim40
entrez
195359
canonical
uniprot
Q3UWA4
canonical
ensembl
ENSMUSG00000073399
resolver
ensp
ENSMUSP00000084400
resolver
ensp
ENSMUSP00000133581
resolver
enst
ENSMUST00000087158
resolver
enst
ENSMUST00000172711
resolver
genesymbol
Trim40
resolver
genesymbol_syn
Gm319
resolver
uniprot
B2RVT3
resolver
uniprot
B7ZWG4
resolver
uniprot
G3UX76
resolver
uniprot_entry
B7ZWG4_MOUSE
resolver
uniprot_entry
G3UX76_MOUSE
resolver
uniprot_entry
TRI40_MOUSE
resolver
uniprot_sec
B2RVT3
resolver
amino_acid_sequence
MGSLDKDNQDICPICLDPLKEAVSTDCRHLFCRMCLTQHMDKASVSGILSCPVCRKPCSEGVLGDNYICHTHQKRVRRFCEASGHLLCEECLQSPEHQSHTELSIENAISHYKERLNRRSRKLRKDLGNLQQLKAQEKKMLQALQVDCECHRLRTDLQNQDQTKEQLKALPWHWLDQEDLPEEVAKIFSFSEAVTQLSILVSGLERMAKDLDASTLKDASDLLDRSAPQKLEGLLSRVSPAGPKLS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response. Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation. Also promotes the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation. {ECO:0000250|UniProtKB:Q6P9F5}.
uniprot
proteins
mass_dalton
27903
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
29117565
uniprot
proteins
sequence_length
246
uniprot
proteins