Fkbp1a
entrez
14225
canonical
uniprot
P26883
canonical
ensembl
ENSMUSG00000032966
resolver
ensp
ENSMUSP00000037206
resolver
ensp
ENSMUSP00000118725
resolver
ensp
ENSMUSP00000345212
resolver
enst
ENSMUST00000044011
resolver
genesymbol
Fkbp1a
resolver
genesymbol_syn
FKBP12-T1
resolver
genesymbol_syn
FKBP12-T2
resolver
genesymbol_syn
Fkbp1
resolver
uniprot
Q1JUQ7
resolver
uniprot
Q1JUQ8
resolver
uniprot
Q3UKJ3
resolver
uniprot
Q545E9
resolver
uniprot_entry
FKB1A_MOUSE
resolver
uniprot_entry
Q1JUQ7_MOUSE
resolver
uniprot_entry
Q1JUQ8_MOUSE
resolver
uniprot_entry
Q3UKJ3_MOUSE
resolver
uniprot_sec
Q545E9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by both FK506 and rapamycin.
uniprot
proteins
amino_acid_sequence
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFTLGKQEVIRGWEEGVAQMSVGQRAKLIISSDYAYGATGHPGIIPPHATLVFDVELLKLE
uniprot
proteins
ec_number
5.2.1.8
uniprot
proteins
function
FUNCTION: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
11923
uniprot
proteins
protein_family
FKBP-type PPIase family
uniprot
proteins
protein_family
FKBP1 subfamily
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1722474
uniprot
proteins
pubmed
18268335
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
108
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62942}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P62943}; Peripheral membrane protein {ECO:0000250|UniProtKB:P62943}; Cytoplasmic side {ECO:0000250|UniProtKB:P62943}.
uniprot
proteins