Ezhip
entrez
102991
canonical
uniprot
B1B0V2
canonical
ensembl
ENSMUSG00000073294
resolver
ensp
ENSMUSP00000099222
resolver
ensp
ENSMUSP00000114041
resolver
genesymbol
Ezhip
resolver
genesymbol_syn
AU022751
resolver
genesymbol_syn
KIP75
resolver
uniprot
Q3TL73
resolver
uniprot
Q3UWZ4
resolver
uniprot
Q497U5
resolver
uniprot_entry
EZHIP_MOUSE
resolver
uniprot_sec
Q3TL73
resolver
uniprot_sec
Q3UWZ4
resolver
uniprot_sec
Q497U5
resolver
amino_acid_sequence
MASSSSPERGLEALRDTDESEGEAPGPSGPRGRGGPSGAGSALRLRSLEAEMAAACVTSTAGEDLGTFSEPGSQHGDPEGGGGPDLELGHARPMMRSQRELGLTPKGGGKADQGGKGRKGGSGSPPHTKSSRKREQPNPNRSLMAQGAAGPPLPGARGSPAMPQPESSLSPRPDQSHHFDFPVGNLEAPGPTLRSSTSQGSGSTPVPEALRCAESSRAESDQSSPAGRELRQQASPRAPDDDDDGDGGPDPRGSGTPEGWVLRSGVVPFGRRSSASEVSPEEVRPEAQCTGWNLRPRPRSSASAVSPEARPKAQSAGRNLRPRPRSSASVVSPEARPKAQSAGRNLRPRPRSSASVVSPEARPEAQSAGRNLRPRATPRVPVAPSSTTRSSSDRGSSRAPRSRSRSRSCSTPRLGSDHQRSRKIKMRLDLQVDREPESEAEQEEQELESEPGPSSRPQASRSSSRFAVPGRSSLAAEDSPPRRPVRMRASSPSPPGRLYPLPKHYFEGVHSPSSSSSESSSVSSSHSPLNKAPDPGSSPPLSSLSGPNPFWLALIADLDNLDSSSPRVPGEEIEAAPHTREEEDKKCRG
uniprot
proteins
function
FUNCTION: Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation at 'Lys-27' (H3K27me3) (PubMed:31086175). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (By similarity). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (PubMed:31451685). {ECO:0000250|UniProtKB:Q86X51, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}.
uniprot
proteins
mass_dalton
61798
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31086175
uniprot
proteins
pubmed
31451685
uniprot
proteins
sequence_length
589
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q86X51}. Cytoplasm {ECO:0000250|UniProtKB:Q86X51}.
uniprot
proteins