Ccl7
entrez
287561
canonical
uniprot
Q9QXY8
canonical
ensembl
ENSRNOG00000000239
resolver
ensembl
ENSRNOG00055025633
resolver
ensembl
ENSRNOG00060019349
resolver
ensembl
ENSRNOG00065019603
resolver
ensp
ENSRNOP00000000256
resolver
ensp
ENSRNOP00055036174
resolver
ensp
ENSRNOP00060027363
resolver
ensp
ENSRNOP00065026377
resolver
enst
ENSRNOT00000000256
resolver
enst
ENSRNOT00055044216
resolver
enst
ENSRNOT00060033438
resolver
enst
ENSRNOT00065033005
resolver
genesymbol
Ccl7
resolver
genesymbol_syn
Mcp3
resolver
genesymbol_syn
Scya7
resolver
uniprot_entry
CCL7_RAT
resolver
amino_acid_sequence
MQISAALLCVLLTAAAFTVHVWAQPDGTNSSTCCYVKKQKIPKRNLKSYRKITSSRCPWEAVIFKTKKGMEVCAEAHQKWVEEAIAYLDMKTSTPKP
uniprot
proteins
function
FUNCTION: Chemotactic factor that plays an important role in immune regulation. Attracts monocytes, eosinophils, basophils, and T-cells to sites of inflammation or infection. Upon binding to various chemokine receptors including CCR1, CCR2, CCR3, and CCR5, facilitates immune cell migration by guiding them to infected tissues. Interacts with CCR2 to facilitate the release of monocytes from the bone marrow into the bloodstream, maintaining monocyte homeostasis. In turn, monocytes recruited to inflamed or injured tissues can differentiate into macrophages or dendritic cells, which are essential for immune defense and tissue repair. Through CCR1, contributes to macrophage polarization via NF-kappa-B activation which leads to the release of inflammatory factors. In the trigeminal ganglion neurons, activates ERK via CCR2 and CCR3 to enhance neuronal excitability, which contributes to the maintenance of trigeminal neuropathic pain. Additionally, modulates the early immune response in the skin, preventing pathogen dissemination while maintaining cutaneous immune control. {ECO:0000250|UniProtKB:P80098, ECO:0000250|UniProtKB:Q03366}.
uniprot
proteins
mass_dalton
10906
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
10521584
uniprot
proteins
sequence_length
97
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins