RND1
entrez
27289
canonical
uniprot
Q92730
canonical
ensembl
ENSG00000172602
resolver
ensp
ENSP00000308461
resolver
enst
ENST00000309739
resolver
genesymbol
RND1
resolver
genesymbol_syn
RHO6
resolver
hgnc
HGNC:18314
resolver
uniprot
A8K9P7
resolver
uniprot_entry
RND1_HUMAN
resolver
uniprot_sec
A8K9P7
resolver
amino_acid_sequence
MKERRAPQPVVARCKLVLVGDVQCGKTAMLQVLAKDCYPETYVPTVFENYTACLETEEQRVELSLWDTSGSPYYDNVRPLCYSDSDAVLLCFDISRPETVDSALKKWRTEILDYCPSTRVLLIGCKTDLRTDLSTLMELSHQKQAPISYEQGCAIAKQLGAEIYLEGSAFTSEKSIHSIFRTASMLCLNKPSPLPQKSPVRSLSKRLLHLPSRSELISSTFKKEKAKSCSIM
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. {ECO:0000269|PubMed:11095956}.
uniprot
proteins
mass_dalton
26056
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="T->N: Impairs interaction with UBXD5."; /evidence="ECO:0000269|PubMed:11940653"; MUTAGEN 45; /note="T->A: Abolishes interaction with UBXD5."; /evidence="ECO:0000269|PubMed:11940653
uniprot
proteins
protein_family
Rho family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10664463
uniprot
proteins
pubmed
11095956
uniprot
proteins
pubmed
11940653
uniprot
proteins
pubmed
12730235
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19843518
uniprot
proteins
pubmed
9531558
uniprot
proteins
sequence_length
232
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11940653}; Lipid-anchor {ECO:0000269|PubMed:11940653}; Cytoplasmic side {ECO:0000269|PubMed:11940653}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11940653}.
uniprot
proteins