Prdm14
entrez
383491
canonical
uniprot
E9Q3T6
canonical
ensembl
ENSMUSG00000042414
resolver
ensp
ENSMUSP00000044245
resolver
enst
ENSMUST00000047577
resolver
genesymbol
Prdm14
resolver
uniprot
Q3URU1
resolver
uniprot_entry
PRD14_MOUSE
resolver
uniprot_sec
Q3URU1
resolver
amino_acid_sequence
MALPPSGETQSQDKANYLPQSNPHHLTTYYAHAPGYSHFRNLATTEEEFQPWKLAAAVLESQAMAPLDAFRMTAPLLNPGLAVQSEPLYNLPWYKLSPWNRIPQFTPEVPRFLDSTEHRSSGSSNQNLVLGGGGGQISGQRWEAENLLLPSPVIASLLPDGIKSSQSISVPQTLNQEGKLPFCGFNFTEEELSFVLYGAIASPEHPTDLQHAISGILVPTESSGSNHLHKTLDKDSLQLPEGLCLMQTSFGDVPHFGVFCSDFIAKGVRFGPFRGRVVNASEVKAHRDNSRMWEIFEDGHLSHFIDGKGSGNWMSYVNCARFPKEQNLLAVQHQGQIFYESCRDIQRNQELLVWYGNGYEKFLGVPMNLRVTEQGGQQLSESSEESAEGYRCERCGKVFTYKYYRDKHLKYTPCVDKGDRKFPCSLCQRSFEKRDRLRIHILHVHERHRPYLCSTCGKSFSQSSSLNKHMRVHSGDRPYQCVYCTKKFTASSILRTHIRQHSGEKPFKCKHCGKAFASHAAHDSHVRRSHKDNGRSSCDICGKGFLDQEAFYAHMRLHKTC
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Transcription factor that has both positive and negative roles on transcription (By similarity). Plays a role in cellular pluripotency. Essential for germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation. {ECO:0000250, ECO:0000269|PubMed:18622394, ECO:0000269|PubMed:26523391}.
uniprot
proteins
mass_dalton
63374
uniprot
proteins
mutagenesis
MUTAGEN 339; /note="Y->R: Impairs interaction with CBFA2T2."; /evidence="ECO:0000269|PubMed:26523391
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18622394
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20953172
uniprot
proteins
pubmed
26523391
uniprot
proteins
pubmed
27281218
uniprot
proteins
sequence_length
561
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins