Got1
entrez
24401
canonical
uniprot
P13221
canonical
ensembl
ENSRNOG00000016356
resolver
ensembl
ENSRNOG00055004126
resolver
ensembl
ENSRNOG00060023531
resolver
ensp
ENSRNOP00000080441
resolver
ensp
ENSRNOP00055005046
resolver
ensp
ENSRNOP00060033749
resolver
enst
ENSRNOT00000119131
resolver
enst
ENSRNOT00055006596
resolver
enst
ENSRNOT00060040812
resolver
genesymbol
Got1
resolver
uniprot
Q64570
resolver
uniprot
Q6P721
resolver
uniprot_entry
AATC_RAT
resolver
uniprot_sec
Q64570
resolver
uniprot_sec
Q6P721
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by L-aspartate. {ECO:0000269|PubMed:7113743}.
uniprot
proteins
amino_acid_sequence
MAPPSFFAQVPQAPPVLVFKLIADFRDDPDPRKVNLGVGAYRTDDSQPWVLPVVRKVEQKIANDHSLNHEYLPILGLAEFRSCASQLVLGDNSPALRENRVGGVQSLGGTGALRIGADFLGRWYNGTDNKNTPVYVSSPTWENHNGVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLENAPEFSIFVLHACAHNPTGTDPTEEEWKQIAAVMKRRFLFPFFDSAYQGFASGDLEKDAWAIRYFVSEGFELFCAQSFSKNFGLYNERVGNLTVVGKEHDSVLRVLSQMEKIVRITWSNPPAQGARIVATTLSNPELFKEWKGNVKTMADRILTMRSELRARLEALKTPGTWSHITEQIGMFSFTGLNPKQVEYLVNEKHIYLMPSGRINMCGLTTKNLDYVATSINEAVTKFQ
uniprot
proteins
ec_number
2.6.1.1
uniprot
proteins
ec_number
2.6.1.3
uniprot
proteins
function
FUNCTION: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. {ECO:0000269|PubMed:17545671, ECO:0000269|PubMed:21266983, ECO:0000269|PubMed:21361730, ECO:0000269|PubMed:3053674, ECO:0000269|PubMed:3182750, ECO:0000269|PubMed:7113743}.
uniprot
proteins
mass_dalton
46429
uniprot
proteins
protein_family
Class-I pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17545671
uniprot
proteins
pubmed
21266983
uniprot
proteins
pubmed
21361730
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2307672
uniprot
proteins
pubmed
3053674
uniprot
proteins
pubmed
3182750
uniprot
proteins
pubmed
3182856
uniprot
proteins
pubmed
7113743
uniprot
proteins
sequence_length
413
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins