Aldh1a3
entrez
56847
canonical
uniprot
Q9JHW9
canonical
ensembl
ENSMUSG00000015134
resolver
ensp
ENSMUSP00000015278
resolver
enst
ENSMUST00000015278
resolver
genesymbol
Aldh1a3
resolver
genesymbol_syn
Aldh6
resolver
genesymbol_syn
Raldh3
resolver
uniprot
Q3UIA4
resolver
uniprot
Q9EQP7
resolver
uniprot
Q9JI72
resolver
uniprot_entry
AL1A3_MOUSE
resolver
uniprot_entry
Q3UIA4_MOUSE
resolver
uniprot_sec
Q9EQP7
resolver
uniprot_sec
Q9JI72
resolver
amino_acid_sequence
MATTNGAVENGQPDGKPPALPRPIRNLEVKFTKIFINNDWHESKSGRKFATYNPSTLEKICEVEEGDKPDVDKAVEAAQAAFQRGSPWRRLDALSRGQLLHQLADLVERDRAILATLETMDTGKPFLHAFFVDLEGCIKTFRYFAGWADKIQGRTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLAWKLAPALCCGNTVVLKPAEQTPLTALYLASLIKEVGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVREAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYGEFVRRSVEFAKKRPVGDPFDAKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDRGLFIKPTVFSDVTDNMRIAKEEIFGPVQPILKFKNLEEVIKRANSTDYGLTAAVFTKNLDKALKLAAALESGTVWINCYNAFYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLEEKNP
uniprot
proteins
ec_number
1.2.1.36
uniprot
proteins
function
FUNCTION: Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (PubMed:11013254, PubMed:11044606, PubMed:14623956, PubMed:15911617). High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (By similarity). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (PubMed:14623956). {ECO:0000250|UniProtKB:P47895, ECO:0000269|PubMed:11013254, ECO:0000269|PubMed:11044606, ECO:0000269|PubMed:14623956, ECO:0000269|PubMed:15911617}.
uniprot
proteins
mass_dalton
56157
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000269|PubMed:11013254, ECO:0000269|PubMed:11044606, ECO:0000269|PubMed:14623956, ECO:0000269|PubMed:15911617}.
uniprot
proteins
protein_family
Aldehyde dehydrogenase family
uniprot
proteins
pubmed
10906479
uniprot
proteins
pubmed
11013254
uniprot
proteins
pubmed
11025231
uniprot
proteins
pubmed
11044606
uniprot
proteins
pubmed
14623956
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15911617
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23536097
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11013254}.
uniprot
proteins