Trim45
entrez
229644
canonical
uniprot
Q6PFY8
canonical
ensembl
ENSMUSG00000033233
resolver
ensp
ENSMUSP00000043389
resolver
ensp
ENSMUSP00000102593
resolver
ensp
ENSMUSP00000115669
resolver
genesymbol
Trim45
resolver
uniprot
E9Q2K9
resolver
uniprot
Q3U5H4
resolver
uniprot
Q8BVT5
resolver
uniprot_entry
TRI45_MOUSE
resolver
uniprot_sec
E9Q2K9
resolver
uniprot_sec
Q3U5H4
resolver
uniprot_sec
Q8BVT5
resolver
amino_acid_sequence
MSEIRKPLLGFVHKLQDANASGSSGKTHCPTCLRLFKVPRLLPCLHTVCTTCLEKLDPFSVVDIRGGDSDTSSEGSVFQDPELCSLQPQIGILCPVCDAQVDLPLGGVKALTVDHLAMNDVLLENLRGEGQGLVCDLCSDREVEKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLKGYSQVGKPILCPSHPAEELRLFCELCDRPVCRDCVVGEHREHPYDFTSNVIHKHGDSVRELLRDTQPHVEALEDALAQIKSVNNALQERVEAVAADVRTFSEGYIKAIEEHRDKLLQQLDDIRIQRETALQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKGVVVERLRKLNKVEYSARPGVNHKICFSPQEKAGQCQGYEVYGAINTQEVDPAQCVLQGEDLHRAREKQTASFTLFCKDASGQSMGRGGDNVHVEVVPKDKKDSPIRTVVQDNKDGSYRVSYTPKEPGIYTVWVCIREQHVQGSPFNVTVRRKHRPHPGVFHCCTFCSSGGQKAARCACGGTMPGGYLGCGHGHKGHPGRPHWSCCGKFIEKSECSFTSGQGAPRSLLRTVAL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response (PubMed:36681779). Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response. May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway. {ECO:0000250|UniProtKB:Q9H8W5, ECO:0000269|PubMed:36681779}.
uniprot
proteins
mass_dalton
64257
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
36681779
uniprot
proteins
sequence_length
580
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H8W5}. Nucleus {ECO:0000250|UniProtKB:Q9H8W5}.
uniprot
proteins