Cdc14b
entrez
218294
canonical
uniprot
Q6PFY9
canonical
ensembl
ENSMUSG00000033102
resolver
ensp
ENSMUSP00000046003
resolver
ensp
ENSMUSP00000105391
resolver
ensp
ENSMUSP00000152388
resolver
ensp
ENSMUSP00000243071
resolver
enst
ENSMUST00000221634
resolver
genesymbol
Cdc14b
resolver
uniprot
A0A1Y7VJB9
resolver
uniprot
Q80WC4
resolver
uniprot
Q8BLV5
resolver
uniprot_entry
A0A1Y7VJB9_MOUSE
resolver
uniprot_entry
CC14B_MOUSE
resolver
uniprot_sec
Q80WC4
resolver
uniprot_sec
Q8BLV5
resolver
amino_acid_sequence
MKRKSERRSAWATAPPCSRRSSSSSPGVKKSRSSTPQELHRLEQQDDLYLDITDRLCFAILYSRPKSATNEHYFSIDNELEYENFYADFGPLNLAMVYRYCCKINKKLKSITMLRKKIIHFTGTDQRKQANAAFLVGCYMVIYLGRTPEDAYRTLIFGDTAYIPFRDAAYGSCSFYITLLDCFHAVKKAMQYGFFNFNSFNLDEYEHYEKAENGDFNWIIPERFLAFCGPHSRSRLESGYHQHSPETYIPYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFPDGSTPAESIVQEFLDICENVKGAIAVHCKAGLGRTGTLIGCYLMKHYRMTAAESIAWLRICRPGSVIGPQQQFLVMKQSSLWLEGDYFRQKLRGQENGPLREAFSKHLSDADDLSLNGLENQDNQEPEPYSDDDEVSGMTQGDRLRALKSRRQPKASAIPLTCPLAVLTSALCSVAIWWIVCDYILPTLLFCLDGFRTQ
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
55661
uniprot
proteins
protein_family
Non-receptor class CDC14 subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
485
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1. {ECO:0000250}.
uniprot
proteins