Rab32
entrez
67844
canonical
uniprot
Q9CZE3
canonical
ensembl
ENSMUSG00000019832
resolver
ensp
ENSMUSP00000019974
resolver
enst
ENSMUST00000019974
resolver
genesymbol
Rab32
resolver
uniprot
Q0PD23
resolver
uniprot
Q3TXU7
resolver
uniprot
Q8BVD3
resolver
uniprot
Q91YN4
resolver
uniprot_entry
Q0PD23_MOUSE
resolver
uniprot_entry
RAB32_MOUSE
resolver
uniprot_sec
Q3TXU7
resolver
uniprot_sec
Q8BVD3
resolver
uniprot_sec
Q91YN4
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine the nucleotide exchange factor (GEF) BLOC-3 complex composed of HPS1 and HPS4 which promote the exchange of bound GDP for free GTP (By similarity). Regulated by the GTPase activating protein (GAP) SGSM2/RUTBC1 which increases the GTP hydrolysis activity (PubMed:26620560). Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation (Probable). {ECO:0000250|UniProtKB:Q13637, ECO:0000269|PubMed:26620560, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MAGEGLGQQGASATAAPETREHLFKVLVIGELGVGKTSIIKRYVHQLFSQHYRATIGVDFALKVLNWDSRTLVRLQLWDIAGQERFGNMTRVYYKEALGAFVVFDISRSSTFDAVLKWKNDLDSKVHLPNGSPIPAVLLANKCDQKKDNSQSPSQMDQFCKDHGFTGWFETSAKDNINIDEATRFLVENMLANQQSFPSEEIDLDRIKLVEEPPTTKPRSQCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Also acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis (By similarity). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (PubMed:26620560). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (By similarity). {ECO:0000250|UniProtKB:Q13637, ECO:0000269|PubMed:26620560}.
uniprot
proteins
mass_dalton
25068
uniprot
proteins
mutagenesis
MUTAGEN 83; /note="Q->L: Inhibits the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes."; /evidence="ECO:0000269|PubMed:26620560"; MUTAGEN 92; /note="V->A: Disrupts interaction with ANKRD27."; /evidence="ECO:0000269|PubMed:21187289
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
14499590
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19403694
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21187289
uniprot
proteins
pubmed
26620560
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q13637}. Mitochondrion outer membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q13637}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Melanosome {ECO:0000269|PubMed:26620560}. Melanosome membrane {ECO:0000250|UniProtKB:Q13637}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization. {ECO:0000250|UniProtKB:Q13637}.
uniprot
proteins