TMC7
entrez
79905
canonical
uniprot
Q7Z402
canonical
ensembl
ENSG00000170537
resolver
ensp
ENSP00000304710
resolver
ensp
ENSP00000397081
resolver
ensp
ENSP00000455041
resolver
ensp
ENSP00000547282
resolver
enst
ENST00000569532
resolver
genesymbol
TMC7
resolver
hgnc
HGNC:23000
resolver
uniprot
E7ERB6
resolver
uniprot
H3BNW8
resolver
uniprot
Q5H9Q8
resolver
uniprot
Q7Z5M4
resolver
uniprot
Q86WX0
resolver
uniprot
Q9H766
resolver
uniprot_entry
H3BNW8_HUMAN
resolver
uniprot_entry
TMC7_HUMAN
resolver
uniprot_sec
E7ERB6
resolver
uniprot_sec
Q5H9Q8
resolver
uniprot_sec
Q7Z5M4
resolver
uniprot_sec
Q86WX0
resolver
uniprot_sec
Q9H766
resolver
amino_acid_sequence
MSESSGSALQPGRPSRQPAVHPENLSLDSSCFSSPPVNFLQELPSYRSIARRRTTVHSRDKQSGTLLKPTDSYSSQLEDRIAENLSSHSLRNYALNISEKRRLRDIQETQMKYLSEWDQWKRYSSKSWKRFLEKAREMTTHLELWREDIRSIEGKFGTGIQSYFSFLRFLVLLNLVIFLIIFMLVLLPVLLTKYKITNSSFVLIPFKDMDKQCTVYPVSSSGLIYFYSYIIDLLSGTGFLEETSLFYGHYTIDGVKFQNFTYDLPLAYLLSTIASLALSLLWIVKRSVEGFKINLIRSEEHFQSYCNKIFAGWDFCITNRSMADLKHSSLRYELRADLEEERMRQKIAERTSEETIRIYSLRLFLNCIVLAVLGACFYAIYVATVFSQEHMKKEIDKMVFGENLFILYLPSIVITLANFITPMIFAKIIRYEDYSPGFEIRLTILRCVFMRLATICVLVFTLGSKITSCDDDTCDLCGYNQKLYPCWETQVGQEMYKLMIFDFIIILAVTLFVDFPRKLLVTYCSSCKLIQCWGQQEFAIPDNVLGIVYGQTICWIGAFFSPLLPAIATLKFIIIFYVKEWSLLYTCRPSPRPFRASNSNFFFLLVLLIGLCLAIIPLTISISRIPSSKACGPFTNFNTTWEVIPKTVSTFPSSLQSFIHGVTSEAFAVPFFMIICLIMFYFIALAGAHKRVVIQLREQLSLESRDKCYLIQKLTEAQRDMRN
uniprot
proteins
function
FUNCTION: Acts as an inhibitory modulator of PIEZO2 mechanosensitive channel in dorsal root ganglion (DRG) neurons through physical interactions or interference with the interaction between PIEZO2 and the cytoskeleton. {ECO:0000250|UniProtKB:Q8C428}.
uniprot
proteins
mass_dalton
83502
uniprot
proteins
protein_family
TMC family
uniprot
proteins
pubmed
12812529
uniprot
proteins
pubmed
12906855
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
723
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 220..240; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 264..284; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 363..383; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 405..425; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 495..515; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 556..576; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 602..622; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 666..686; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins