NME6
entrez
10201
canonical
uniprot
O75414
canonical
ensembl
ENSG00000172113
resolver
ensp
ENSP00000393261
resolver
ensp
ENSP00000394232
resolver
ensp
ENSP00000399582
resolver
ensp
ENSP00000406642
resolver
ensp
ENSP00000407933
resolver
ensp
ENSP00000411116
resolver
ensp
ENSP00000414842
resolver
ensp
ENSP00000416658
resolver
ensp
ENSP00000495130
resolver
ensp
ENSP00000496560
resolver
ensp
ENSP00000555478
resolver
ensp
ENSP00000655876
resolver
ensp
ENSP00000704354
resolver
ensp
ENSP00000781562
resolver
enst
ENST00000447314
resolver
enst
ENST00000643011
resolver
genesymbol
NME6
resolver
hgnc
HGNC:20567
resolver
uniprot
A0A0C4DG91
resolver
uniprot
A0A2R8Y7V2
resolver
uniprot
B4DGW7
resolver
uniprot
B4DM99
resolver
uniprot
C9JQB1
resolver
uniprot
Q53HM5
resolver
uniprot
Q96E73
resolver
uniprot
Q9BQ63
resolver
uniprot_entry
A0A2R8Y7V2_HUMAN
resolver
uniprot_entry
C9JQB1_HUMAN
resolver
uniprot_entry
NDK6_HUMAN
resolver
uniprot_sec
A0A0C4DG91
resolver
uniprot_sec
B4DGW7
resolver
uniprot_sec
B4DM99
resolver
uniprot_sec
Q53HM5
resolver
uniprot_sec
Q96E73
resolver
uniprot_sec
Q9BQ63
resolver
amino_acid_sequence
MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMGPTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLRCGPVCYSPEGGVHYVAGTGGLGPA
uniprot
proteins
ec_number
2.7.4.6
uniprot
proteins
function
FUNCTION: Catalytic subunit of a complex with RCC1L, which catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving the formation of a phosphohistidine intermediate (PubMed:10618642, PubMed:34789336, PubMed:37770567). Participates in the regulation of mitochondrial nucleotide levels, mitoribosome biogenesis, and mitochondrial RNA abundances (PubMed:10618642, PubMed:34789336, PubMed:37770567). Supplies pyrimidine ribonucleoside triphosphates (rNTPs) for mitochondrial transcription and is required for the maintenance of mitochondrial DNA (mtDNA) when the import of pyrimidine deoxyribonucleoside triphosphates (dNTPs) is limited from the cytosol is limited (PubMed:37439264). As a monomer, lacks nucleoside diphosphate kinase (NDPK) activity (PubMed:34789336). {ECO:0000269|PubMed:10618642, ECO:0000269|PubMed:34789336, ECO:0000269|PubMed:37439264, ECO:0000269|PubMed:37770567}.
uniprot
proteins
mass_dalton
21142
uniprot
proteins
mutagenesis
MUTAGEN 129; /note="H->A: Loss interaction with RCCL1. Loss of phosphorylation. Loss of nucleoside diphosphate kinase activity."; /evidence="ECO:0000269|PubMed:37770567"; MUTAGEN 129; /note="H->N: Affects mitochondrial DNA level."; /evidence="ECO:0000269|PubMed:37439264
uniprot
proteins
protein_family
NDK family
uniprot
proteins
pubmed
10453732
uniprot
proteins
pubmed
10618642
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
34789336
uniprot
proteins
pubmed
37439264
uniprot
proteins
pubmed
37770567
uniprot
proteins
sequence_length
186
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:34789336, ECO:0000269|PubMed:37770567}. Mitochondrion inner membrane {ECO:0000269|PubMed:34789336}; Peripheral membrane protein {ECO:0000269|PubMed:34789336}. Mitochondrion {ECO:0000269|PubMed:10618642}. Note=Predominantly localized in mitochondrion matrix, however partially bound to mitochondrion inner membrane (MIM), peripherally bound and facing the matrix space. {ECO:0000269|PubMed:34789336}.
uniprot
proteins