NANOS1
entrez
340719
canonical
uniprot
Q8WY41
canonical
ensembl
ENSG00000188613
resolver
ensp
ENSP00000393275
resolver
enst
ENST00000425699
resolver
genesymbol
NANOS1
resolver
genesymbol_syn
NOS1
resolver
hgnc
HGNC:23044
resolver
uniprot_entry
NANO1_HUMAN
resolver
amino_acid_sequence
MEAFPWAPRSPRRGRAPPPMALVPSARYVSAPGPAHPQPFSSWNDYLGLATLITKAVDGEPRFGCARGGNGGGGSPPSSSSSSCCSPHTGAGPGALGPALGPPDYDEDDDDDSDEPGSRGRYLGSALELRALELCAGPAEAGLLEERFAELSPFAGRAAAVLLGCAPAAAAAATTTSEATPREERAPAWAAEPRLHAASGAAAARLLKPELQVCVFCRNNKEAMALYTTHILKGPDGRVLCPVLRRYTCPLCGASGDNAHTIKYCPLSKVPPPPARPPPRSARDGPPGKKLR
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 12 (SPGF12) [MIM:615413]: An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. Non-obstructive azoospermia, oligozoospermia and oligo-astheno-teratozoospermia are features observed in SPGF12 patients. {ECO:0000269|PubMed:23315541}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. {ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:18223680}.
uniprot
proteins
mass_dalton
30230
uniprot
proteins
protein_family
Nanos family
uniprot
proteins
pubmed
12690449
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
17047063
uniprot
proteins
pubmed
18223680
uniprot
proteins
pubmed
19168546
uniprot
proteins
pubmed
21421998
uniprot
proteins
pubmed
21800163
uniprot
proteins
pubmed
23315541
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:19168546}. Cytoplasm {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:19168546}. Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells. {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:19168546}.
uniprot
proteins