Bfar
entrez
304709
canonical
uniprot
Q5PQN2
canonical
ensembl
ENSRNOG00000003151
resolver
ensembl
ENSRNOG00000084995
resolver
ensembl
ENSRNOG00055005086
resolver
ensembl
ENSRNOG00060012751
resolver
ensp
ENSRNOP00000004217
resolver
ensp
ENSRNOP00000078143
resolver
ensp
ENSRNOP00000101903
resolver
ensp
ENSRNOP00055006160
resolver
ensp
ENSRNOP00060017129
resolver
enst
ENSRNOT00000099882
resolver
enst
ENSRNOT00000134333
resolver
enst
ENSRNOT00055008150
resolver
enst
ENSRNOT00060021662
resolver
genesymbol
Bfar
resolver
uniprot
A0A8I5Y9Y1
resolver
uniprot_entry
A0A8I5Y9Y1_RAT
resolver
uniprot_entry
BFAR_RAT
resolver
amino_acid_sequence
MEEPQKNDLSMRGQEEDHPVRSSGPQISVSEFSCHCCYDTLVNPTTLNCGHSFCRHCLALWWMSSKKTECPECREKWEGFPKVNILLRDAIEKLFPDAIKMRVEDIQQNNDVVQSLAAFQKYGNDQNPLAPSTGRVNQQRGGGFFSGVLTALTGVAVILLVYHWRSRESEHGLLVHKAVDKWTTEEVVLWLEQLGPWASLYRDRFLSERVNGRLLLTLTEEEFSRAPYTIENSSHRRVILMELERVRALGVKPPQNLWEYKAVNPGRSLFLLYALKSSPRLGLLYLYLFDYTDSFLPFIHTICPLQEDSFGEDIFTKLLDLREPTWKQWREFLIKYSFLPYQLIAEFAWDWLEVHYWTSRFLIVNAMLLSVLELFSFWRIWSRSELKTVPQRMWSHFWKVSTQGLFMAMFWPLIPQFVCNCLFYWALYFNPIINIDLVVKEIRRLETQVF
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Membrane-bound E3 ubiquitin ligase that plays a role in several processes including apoptosis regulation or reticulum endoplasmic stress. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. Contributes to the dynamic control of IRE1/ERN1 signaling during ER stress by inducing BAX inhibitor 1/TMBIM6 proteasomal degradation. Promotes the activation of TGF-beta signaling by mediating the 'Lys-63'-linked ubiquitination of TGFBR1 which is critical to activate the pathway. Together with NGFR, negatively regulates NF-kappa-B and JNK-related signaling pathways. Promotes the proteasome-mediated degradation of PNPLA3, a protein involveld in lipid metabolism. {ECO:0000250|UniProtKB:Q9NZS9}.
uniprot
proteins
mass_dalton
53024
uniprot
proteins
post_translational_modification
PTM: Mediates RING-dependent self-ubiquitination leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q9NZS9}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NZS9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NZS9}.
uniprot
proteins
transmembrane_region
TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 332..352; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 361..381; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 405..425; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins