Cbln4
entrez
228942
canonical
uniprot
Q8BME9
canonical
ensembl
ENSMUSG00000067578
resolver
ensp
ENSMUSP00000085263
resolver
enst
ENSMUST00000087950
resolver
genesymbol
Cbln4
resolver
genesymbol_syn
Cblnl1
resolver
uniprot
Q505H5
resolver
uniprot
Q8BMF0
resolver
uniprot_entry
CBLN4_MOUSE
resolver
uniprot_sec
Q505H5
resolver
uniprot_sec
Q8BMF0
resolver
amino_acid_sequence
MGSARRALSVVPAVLLILVLPVWAQNDTEPIVLEGKCLVVCDSNPATDSKGSSSSPLGISVRAANSKVAFSAVRSTNHEPSEMSNKTRIIYFDQILVNVGNFFTLESVFVAPRKGIYSFSFHVIKVYQSQTIQVNLMLNGKPVISAFAGDKDVTREAATNGVLLYLDKEDKVYLKLEKGNLLGGWQYSTFSGFLVFPL
uniprot
proteins
function
FUNCTION: Acts as a synaptic organizer in specific subsets of neurons in the brain (PubMed:29691328). Essential for the formation and maintenance of inhibitory GABAergic synapses (PubMed:25534236). Promotes the development of dendrite-targeting inhibitory GABAergic synapses made by somatostatin-positive interneurons (PubMed:30679375). May contribute to the function of ventral medial habenula region of the brain implicated in the regulation of anxiety-related behaviors (PubMed:30287486). May play a role in CBLN3 export from the endoplasmic reticulum and secretion (PubMed:17030622). {ECO:0000269|PubMed:17030622, ECO:0000269|PubMed:25534236, ECO:0000269|PubMed:29691328, ECO:0000269|PubMed:30287486, ECO:0000269|PubMed:30679375}.
uniprot
proteins
mass_dalton
21609
uniprot
proteins
mutagenesis
MUTAGEN 26; /note="N->Q: No effect on its ability to form homohexameric or heteromeric complexes with other CBLN family members. Increased interaction with NRXN1, NRXN3 and DCC. Shows interaction with NEO1, GRID1 and GRID2. Total loss of N-glycosylation; when associated with Q-85."; /evidence="ECO:0000269|PubMed:17331201, ECO:0000269|PubMed:29782851"; MUTAGEN 85; /note="N->Q: No effect on its ability to form homohexameric or heteromeric complexes with other CBLN family members. Increased interaction with NRXN1, NRXN3 and DCC. Shows interaction with NEO1, GRID1 and GRID2. Total loss of N-glycosylation; when associated with Q-26."; /evidence="ECO:0000269|PubMed:17331201, ECO:0000269|PubMed:29782851
uniprot
proteins
post_translational_modification
PTM: Sialoglycoprotein. {ECO:0000269|PubMed:29782851}.
uniprot
proteins
pubmed
12617826
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16930405
uniprot
proteins
pubmed
17030622
uniprot
proteins
pubmed
17331201
uniprot
proteins
pubmed
22220752
uniprot
proteins
pubmed
25534236
uniprot
proteins
pubmed
29691328
uniprot
proteins
pubmed
29782851
uniprot
proteins
pubmed
30287486
uniprot
proteins
pubmed
30679375
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17030622, ECO:0000269|PubMed:17331201, ECO:0000269|PubMed:29782851}. Synapse {ECO:0000269|PubMed:25534236}. Note=Detected at GABAergic synapses. {ECO:0000269|PubMed:25534236}.
uniprot
proteins