Daam2
entrez
76441
canonical
uniprot
Q80U19
canonical
ensembl
ENSMUSG00000040260
resolver
ensp
ENSMUSP00000052085
resolver
ensp
ENSMUSP00000253476
resolver
ensp
ENSMUSP00000253477
resolver
ensp
ENSMUSP00000253478
resolver
ensp
ENSMUSP00000253479
resolver
ensp
ENSMUSP00000253487
resolver
ensp
ENSMUSP00000253490
resolver
genesymbol
Daam2
resolver
genesymbol_syn
Kiaa0381
resolver
uniprot
E9QNU9
resolver
uniprot
Q6TAB7
resolver
uniprot
Q810J5
resolver
uniprot_entry
DAAM2_MOUSE
resolver
uniprot_sec
E9QNU9
resolver
uniprot_sec
Q6TAB7
resolver
uniprot_sec
Q810J5
resolver
amino_acid_sequence
MALRKRSPHGLGFLCCFGGSDLPEIDLRDSHPLQYLEFSGPIPNPEELNVRFAELVDELDLTDKNREAVFALPPEKKWQIYCSKRKEQEDPNKLATSWPEYYIDRINAMAAMQNLYETEDEETDKRNQVVEDLKTALRTQPMRFVTRFIDLEGLTCLLNFLRGMDHTTCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISIIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQAYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKHTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELMSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVARHNESSTGPVSSPPPPGGPLTLSSSRTTNDLPPPPPPLPFDSCPPPPAPPLPPGGPPIPPGAPPCFSSGPPPSHDPFSSNEAPLRKKRIPQPSHPLKSFNWVKLNEERVSGTVWNEIDDSQVFRILDLEDFEKMFSAYQRHQACMQEGPQRERGNVRDGGAASRPLPAVEASAHRTEKASRSMVSATGAKKELGSTEDIYITSRKVKELSVIDGRRAQNCIILLSKLKLSNDEIRQAILRMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELTLSQRLKQMLEVVLAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELKHLSEAAKVNLAELEKEVSILRRGLRAVEVELEYQRHQARDPNDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALTHFGEQESKMQPDEFFGIFDTFLQAFLEARQDLEAMRRRKEEDERRARMEFMLKEQREKERWQRQRKVLAGGALEESGEFDDLVSALRSGEVFDKDLSKFKRNRKRPGSQVPEVTRERAINRLNY
uniprot
proteins
function
FUNCTION: Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system (PubMed:22227309, PubMed:24091014, PubMed:25754822). Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1) (PubMed:22227309, PubMed:25754822). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity (PubMed:22227309). During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A (PubMed:25754822). Also regulates non-canonical Wnt signaling pathway (PubMed:24091014). Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation (PubMed:24091014). Together with DAAM1, required for myocardial maturation and sarcomere assembly (PubMed:26526197). Is a regulator of actin nucleation and elongation, filopodia formation and podocyte migration (By similarity). {ECO:0000250|UniProtKB:Q86T65, ECO:0000269|PubMed:22227309, ECO:0000269|PubMed:24091014, ECO:0000269|PubMed:25754822, ECO:0000269|PubMed:26526197}.
uniprot
proteins
mass_dalton
128370
uniprot
proteins
protein_family
Formin homology family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15464228
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15533824
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22227309
uniprot
proteins
pubmed
24091014
uniprot
proteins
pubmed
25754822
uniprot
proteins
pubmed
26526197
uniprot
proteins
sequence_length
1115
uniprot
proteins