Penk
entrez
18619
canonical
uniprot
P22005
canonical
ensembl
ENSMUSG00000045573
resolver
ensp
ENSMUSP00000066822
resolver
ensp
ENSMUSP00000203333
resolver
enst
ENSMUST00000070375
resolver
genesymbol
Penk
resolver
genesymbol_syn
Penk1
resolver
uniprot
Q3UXY8
resolver
uniprot
Q68G73
resolver
uniprot_entry
PENK_MOUSE
resolver
uniprot_entry
Q3UXY8_MOUSE
resolver
uniprot_sec
Q68G73
resolver
amino_acid_sequence
MARFLRLCTWLLALGSCLLATVQAECSQDCAKCSYRLVRPGDINFLACTLECEGQLPSFKIWETCKDLLQVSRPEFPWDNIDMYKDSSKQDESHLLAKKYGGFMKRYGGFMKKMDELYPMEPEEEANGGEILAKRYGGFMKKDADEGDTLANSSDLLKELLGTGDNRAKDSHQQESTNNDEDMSKRYGGFMRSLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAESLPSDEEGENYSKEVPEIEKRYGGFMRF
uniprot
proteins
function
FUNCTION: [Met-enkephalin]: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. {ECO:0000250|UniProtKB:P01210}.; FUNCTION: [Leu-enkephalin]: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. {ECO:0000250|UniProtKB:P01210}.; FUNCTION: [Met-enkephalin-Arg-Phe]: Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1 (PubMed:35201898, PubMed:6933569). Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release (PubMed:35201898). {ECO:0000269|PubMed:35201898, ECO:0000269|PubMed:6933569}.; FUNCTION: [PENK(114-133)]: Increases glutamate release in the striatum and decreases GABA concentration in the striatum. {ECO:0000250|UniProtKB:P04094}.; FUNCTION: [PENK(238-259)]: Increases glutamate release in the striatum. {ECO:0000250|UniProtKB:P04094}.; FUNCTION: [Neuropeptide BAM22]: Neuropeptide that mediates stress-induced opioid analgesia (By similarity). Also possesses non-opioid action by acting as a ligand for MRGPRX1 receptor to induce itch in a histamine-independent manner (By similarity). {ECO:0000250|UniProtKB:P01210, ECO:0000250|UniProtKB:P04094}.; FUNCTION: [Neuropeptide BAM8-22]: Neuropeptide that induces itch in a histamine-independent manner as well as nociceptive sensations (PubMed:31350433). Acts as a ligand for MRGPRX1 receptor in sensory neurons of dorsal root ganglion: MRGPRX1-binding in the peripheral nervous system elicits itch and scratching, while MRGPRX1-binding in the central nervous system dampens chronic pain (PubMed:31350433). {ECO:0000269|PubMed:31350433}.
uniprot
proteins
mass_dalton
31004
uniprot
proteins
post_translational_modification
PTM: Proenkephalin-A is cleaved by CTSL to generate Met-enkephalin. {ECO:0000250|UniProtKB:P01211}.; PTM: [Met-enkephalin]: Processed and degraded by ACE. {ECO:0000250|UniProtKB:P01210}.; PTM: [Leu-enkephalin]: Processed and degraded by ACE. {ECO:0000250|UniProtKB:P01210}.; PTM: [Met-enkephalin-Arg-Ser-Leu]: Probably cleaved by ACE. {ECO:0000250|UniProtKB:P01210}.; PTM: [Met-enkephalin-Arg-Phe]: Processed by ACE to generate Met-enkephalin in the nucleus accumbens of the brain. {ECO:0000269|PubMed:35201898}.; PTM: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. {ECO:0000250|UniProtKB:P01210}.
uniprot
proteins
protein_family
Opioid neuropeptide precursor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2355920
uniprot
proteins
pubmed
2938259
uniprot
proteins
pubmed
31350433
uniprot
proteins
pubmed
35201898
uniprot
proteins
pubmed
6933569
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen {ECO:0000250|UniProtKB:P01211}. Secreted {ECO:0000250|UniProtKB:P01211}.
uniprot
proteins