Hsd17b2
entrez
15486
canonical
uniprot
P51658
canonical
ensembl
ENSMUSG00000031844
resolver
ensp
ENSMUSP00000034304
resolver
enst
ENSMUST00000034304
resolver
genesymbol
Hsd17b2
resolver
genesymbol_syn
Edh17b2
resolver
uniprot
O08898
resolver
uniprot_entry
DHB2_MOUSE
resolver
uniprot_sec
O08898
resolver
amino_acid_sequence
MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH
uniprot
proteins
ec_number
1.1.1.239
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
function
FUNCTION: Catalyzes the NAD-dependent oxidation of highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity. {ECO:0000250|UniProtKB:P37059}.
uniprot
proteins
mass_dalton
41836
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9224647
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P37059}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P37059}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins