KIF21A
entrez
55605
canonical
uniprot
Q7Z4S6
canonical
ensembl
ENSG00000139116
resolver
ensp
ENSP00000354851
resolver
ensp
ENSP00000354878
resolver
ensp
ENSP00000438075
resolver
ensp
ENSP00000445606
resolver
ensp
ENSP00000490369
resolver
ensp
ENSP00000524221
resolver
ensp
ENSP00000524222
resolver
ensp
ENSP00000589113
resolver
ensp
ENSP00000589114
resolver
ensp
ENSP00000589115
resolver
genesymbol
KIF21A
resolver
genesymbol_syn
KIAA1708
resolver
genesymbol_syn
KIF2
resolver
hgnc
HGNC:19349
resolver
uniprot
A8MX28
resolver
uniprot
B0I1R9
resolver
uniprot
B9EGE4
resolver
uniprot
F5H0C3
resolver
uniprot
F5H219
resolver
uniprot
Q2UVF1
resolver
uniprot
Q6UKL9
resolver
uniprot
Q7Z668
resolver
uniprot
Q86WZ5
resolver
uniprot
Q8IVZ8
resolver
uniprot
Q9C0F5
resolver
uniprot
Q9NXU4
resolver
uniprot
Q9Y590
resolver
uniprot_entry
KI21A_HUMAN
resolver
uniprot_sec
A8MX28
resolver
uniprot_sec
B0I1R9
resolver
uniprot_sec
B9EGE4
resolver
uniprot_sec
F5H0C3
resolver
uniprot_sec
F5H219
resolver
uniprot_sec
Q2UVF1
resolver
uniprot_sec
Q6UKL9
resolver
uniprot_sec
Q7Z668
resolver
uniprot_sec
Q86WZ5
resolver
uniprot_sec
Q8IVZ8
resolver
uniprot_sec
Q9C0F5
resolver
uniprot_sec
Q9NXU4
resolver
uniprot_sec
Q9Y590
resolver
amino_acid_sequence
MLGAPDESSVRVAVRIRPQLAKEKIEGCHICTSVTPGEPQVFLGKDKAFTFDYVFDIDSQQEQIYIQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNIVEEELGIISRAVKHLFKSIEEKKHIAIKNGLPAPDFKVNAQFLELYNEEVLDLFDTTRDIDAKSKKSNIRIHEDSTGGIYTVGVTTRTVNTESEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQIDADNATDNKIISESAQMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQQINALRSEITRLQMELMEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDALRSRITQLVSDQANHVLARAGEGNEEISNMIHSYIKEIEDLRAKLLESEAVNENLRKNLTRATARAPYFSGSSTFSPTILSSDKETIEIIDLAKKDLEKLKRKEKRKKKRLQKLEESNREERSVAGKEDNTDTDQEKKEEKGVSERENNELEVEESQEVSDHEDEEEEEEEEEDDIDGGESSDESDSESDEKANYQADLANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVRSEYEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMKEEQEKARLTESRRNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSDKVAGKVTRKLSSSDAPAQDTGSSAAAVETDASRTGAQQKMRIPVARVQALPTPATNGNRKKYQRKGLTGRVFISKTARMKWQLLERRVTDIIMQKMTISNMEADMNRLLKQREELTKRREKLSKRREKIVKENGEGDKNVANINEEMESLTANIDYINDSISDCQANIMQMEEAKEEGETLDVTAVINACTLTEARYLLDHFLSMGINKGLQAAQKEAQIKVLEGRLKQTEITSATQNQLLFHMLKEKAELNPELDALLGHALQDLDSVPLENVEDSTDEDAPLNSPGSEGSTLSSDLMKLCGEVKPKNKARRRTTTQMELLYADSSELASDTSTGDASLPGPLTPVAEGQEIGMNTETSGTSAREKELSPPPGLPSKIGSISRQSSLSEKKIPEPSPVTRRKAYEKAEKSKAKEQKHSDSGTSEASLSPPSSPPSRPRNELNVFNRLTVSQGNTSVQQDKSDESDSSLSEVHRSSRRGIINPFPASKGIRAFPLQCIHIAEGHTKAVLCVDSTDDLLFTGSKDRTCKVWNLVTGQEIMSLGGHPNNVVSVKYCNYTSLVFTVSTSYIKVWDIRDSAKCIRTLTSSGQVTLGDACSASTSRTVAIPSGENQINQIALNPTGTFLYAASGNAVRMWDLKRFQSTGKLTGHLGPVMCLTVDQISSGQDLIITGSKDHYIKMFDVTEGALGTVSPTHNFEPPHYDGIEALTIQGDNLFSGSRDNGIKKWDLTQKDLLQQVPNAHKDWVCALGVVPDHPVLLSGCRGGILKVWNMDTFMPVGEMKGHDSPINAICVNSTHIFTAADDRTVRIWKARNLQDGQISDTGDLGEDIASN
uniprot
proteins
disease_involvement
DISEASE: Fibrosis of extraocular muscles, congenital, 1 (CFEOM1) [MIM:135700]: A congenital ocular motility disorder marked by restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. It is clinically characterized by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. Patients affected by congenital fibrosis of extraocular muscles type 1 show an absence of the superior division of the oculomotor nerve (cranial nerve III) and corresponding oculomotor subnuclei. {ECO:0000269|PubMed:14595441, ECO:0000269|PubMed:16157808, ECO:0000269|PubMed:17511870, ECO:0000269|PubMed:18332320, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:24715754}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}.
uniprot
proteins
mass_dalton
187179
uniprot
proteins
mutagenesis
MUTAGEN 1154; /note="R->A: Very weak binding affinity for KANK1 and KANK2."; /evidence="ECO:0000269|PubMed:29183992"; MUTAGEN 1164; /note="L->A: Does not bind to KANK1 or KANK2."; /evidence="ECO:0000269|PubMed:29183992
uniprot
proteins
protein_family
Kinesin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
10508479
uniprot
proteins
pubmed
11214970
uniprot
proteins
pubmed
14595441
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16157808
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17511870
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18332320
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24120883
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24715754
uniprot
proteins
pubmed
27410476
uniprot
proteins
pubmed
29183992
uniprot
proteins
pubmed
30135143
uniprot
proteins
sequence_length
1674
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QXL2}. Cytoplasm, cell cortex {ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:27410476}. Cell projection, axon {ECO:0000269|PubMed:24120883}. Cell projection, dendrite {ECO:0000269|PubMed:24120883}. Cell projection, growth cone {ECO:0000269|PubMed:24120883}.
uniprot
proteins