Kars1
entrez
292028
canonical
uniprot
Q5XIM7
canonical
ensembl
ENSRNOG00000019456
resolver
ensembl
ENSRNOG00055018906
resolver
ensembl
ENSRNOG00060012773
resolver
ensp
ENSRNOP00000044454
resolver
ensp
ENSRNOP00000080260
resolver
ensp
ENSRNOP00055026134
resolver
ensp
ENSRNOP00060017204
resolver
enst
ENSRNOT00000046126
resolver
enst
ENSRNOT00000117076
resolver
enst
ENSRNOT00055032299
resolver
enst
ENSRNOT00060021737
resolver
genesymbol
Kars1
resolver
genesymbol_syn
Kars
resolver
uniprot
A0A8I5ZPX4
resolver
uniprot_entry
A0A8I5ZPX4_RAT
resolver
uniprot_entry
SYK_RAT
resolver
amino_acid_sequence
MLMQAAVRLVRGSLRQTSWAEWGQRELRLGQLAPFTTLRKDKPLSDRRSELKRRLKAEKKLAEKEAKQKELSEKQLNQTTAAAATNHTADNGVGAEEETLDPNQYYKIRSQAVQQLKVSGEDPYPHKFHVDISLTQFIQEYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFVHINNKLRRGDIIGVEGNPGKTKKGELSIVPREMTLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMLSGMVRSITGSYKITYHPDGPEGQAYEIDFTPPFRRISMVEELEKVLGVKLPETSLFETEETRKILDDICVARAVECPPPRTTARLLDKLVGEFLEVTCISPTFICDHPQIMSPLAKWHRCKEGLTERFELFVMKKEICNAYTELNDPVRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVTMFLTDSNNIKEVLLFPAMKPEDKKETATATETPESTEASPSV
uniprot
proteins
ec_number
2.7.7.-
uniprot
proteins
ec_number
6.1.1.6
uniprot
proteins
function
FUNCTION: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:6315704). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (By similarity). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:19524539, PubMed:2995387, PubMed:3988754). {ECO:0000250|UniProtKB:Q15046, ECO:0000269|PubMed:19524539, ECO:0000269|PubMed:2995387, ECO:0000269|PubMed:3988754, ECO:0000269|PubMed:6315704}.
uniprot
proteins
mass_dalton
71623
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on a serine residue after mast cell stimulation with immunoglobulin E (IgE). {ECO:0000269|PubMed:19524539}.
uniprot
proteins
protein_family
Class-II aminoacyl-tRNA synthetase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19524539
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23159739
uniprot
proteins
pubmed
2995387
uniprot
proteins
pubmed
3988754
uniprot
proteins
pubmed
6315704
uniprot
proteins
sequence_length
626
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19524539, ECO:0000269|PubMed:23159739}. Cytoplasm {ECO:0000250|UniProtKB:Q15046}. Nucleus {ECO:0000269|PubMed:19524539, ECO:0000269|PubMed:23159739}. Cell membrane {ECO:0000250|UniProtKB:Q15046}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15046}. Secreted {ECO:0000250|UniProtKB:Q15046}. Note=Secretion is induced by TNF (By similarity). Cytosolic in quiescent mast cells. Translocates into the nucleus in response to mast cell activation by immunoglobulin E (PubMed:19524539, PubMed:23159739). {ECO:0000250|UniProtKB:Q15046, ECO:0000269|PubMed:19524539, ECO:0000269|PubMed:23159739}.
uniprot
proteins