BCL2L11
entrez
10018
canonical
uniprot
O43521
canonical
ensembl
ENSG00000153094
resolver
ensp
ENSP00000309226
resolver
ensp
ENSP00000354879
resolver
ensp
ENSP00000376941
resolver
ensp
ENSP00000376943
resolver
ensp
ENSP00000384641
resolver
ensp
ENSP00000389225
resolver
ensp
ENSP00000391292
resolver
ensp
ENSP00000393781
resolver
ensp
ENSP00000394640
resolver
ensp
ENSP00000403727
resolver
ensp
ENSP00000411137
resolver
ensp
ENSP00000412892
resolver
ensp
ENSP00000666148
resolver
ensp
ENSP00000666149
resolver
ensp
ENSP00000666150
resolver
ensp
ENSP00000790987
resolver
enst
ENST00000361493
resolver
enst
ENST00000393252
resolver
enst
ENST00000438054
resolver
genesymbol
BCL2L11
resolver
genesymbol_syn
BIM
resolver
hgnc
HGNC:994
resolver
uniprot
A0A0C4DH20
resolver
uniprot
A8K2W2
resolver
uniprot
E9PAM9
resolver
uniprot
H7BZE5
resolver
uniprot
O43522
resolver
uniprot
Q0MSE7
resolver
uniprot
Q0MSE8
resolver
uniprot
Q0MSE9
resolver
uniprot
Q53R28
resolver
uniprot
Q6JTU6
resolver
uniprot
Q6T851
resolver
uniprot
Q6TE14
resolver
uniprot
Q6TE15
resolver
uniprot
Q6TE16
resolver
uniprot
Q6V402
resolver
uniprot
Q8WYL6
resolver
uniprot
Q8WYL7
resolver
uniprot
Q8WYL8
resolver
uniprot
Q8WYL9
resolver
uniprot
Q8WYM0
resolver
uniprot
Q8WYM1
resolver
uniprot_entry
A0A0C4DH20_HUMAN
resolver
uniprot_entry
B2L11_HUMAN
resolver
uniprot_entry
E9PAM9_HUMAN
resolver
uniprot_entry
H7BZE5_HUMAN
resolver
uniprot_sec
A8K2W2
resolver
uniprot_sec
O43522
resolver
uniprot_sec
Q0MSE7
resolver
uniprot_sec
Q0MSE8
resolver
uniprot_sec
Q0MSE9
resolver
uniprot_sec
Q53R28
resolver
uniprot_sec
Q6JTU6
resolver
uniprot_sec
Q6T851
resolver
uniprot_sec
Q6TE14
resolver
uniprot_sec
Q6TE15
resolver
uniprot_sec
Q6TE16
resolver
uniprot_sec
Q6V402
resolver
uniprot_sec
Q8WYL6
resolver
uniprot_sec
Q8WYL7
resolver
uniprot_sec
Q8WYL8
resolver
uniprot_sec
Q8WYL9
resolver
uniprot_sec
Q8WYM0
resolver
uniprot_sec
Q8WYM1
resolver
amino_acid_sequence
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH
uniprot
proteins
function
FUNCTION: Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269|PubMed:11997495, ECO:0000269|PubMed:15486195, ECO:0000269|PubMed:15661735, ECO:0000269|PubMed:9430630}.
uniprot
proteins
mass_dalton
22171
uniprot
proteins
mutagenesis
MUTAGEN 156; /note="G->A: Retains the ability to induce apoptosis. Abolishes interaction with BAX; in isoform Bim-alpha3 and isoform BimS. No effect on interaction with BCL2."; /evidence="ECO:0000269|PubMed:11997495, ECO:0000269|PubMed:17289999"; MUTAGEN 156; /note="G->E: Abolishes induction of apoptosis. Abolishes interaction with BAX and BCL2; in isoform Bim-alpha3 and isoform BimS. Loses the ability to induce the conformationally active form of BAX."; /evidence="ECO:0000269|PubMed:11997495, ECO:0000269|PubMed:17289999"; MUTAGEN 160; /note="N->A: Retains the ability to induce apoptosis. Abolishes interaction with BCL2; in isoform Bim-alpha3 and isoform BimS. No effect on interaction with BAX."; /evidence="ECO:0000269|PubMed:11997495
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-69 by MAPK1/MAPK3 leads to interaction with TRIM2 and polyubiquitination, followed by proteasomal degradation (PubMed:15486195, PubMed:21478148). Deubiquitination catalyzed by USP27X stabilizes the protein (By similarity). {ECO:0000250|UniProtKB:O54918, ECO:0000269|PubMed:15486195, ECO:0000269|PubMed:21478148}.; PTM: Ubiquitination by TRIM2 following phosphorylation by MAPK1/MAPK3 leads to proteasomal degradation. Conversely, deubiquitination catalyzed by USP27X stabilizes the protein. {ECO:0000250|UniProtKB:O54918}.
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
11734221
uniprot
proteins
pubmed
11997495
uniprot
proteins
pubmed
12019181
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15147734
uniprot
proteins
pubmed
15486195
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15661735
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16509771
uniprot
proteins
pubmed
17289999
uniprot
proteins
pubmed
17389404
uniprot
proteins
pubmed
17503221
uniprot
proteins
pubmed
18812174
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21478148
uniprot
proteins
pubmed
22498477
uniprot
proteins
pubmed
22761832
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23235460
uniprot
proteins
pubmed
23563182
uniprot
proteins
pubmed
27013495
uniprot
proteins
pubmed
9430630
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with intracytoplasmic membranes. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform BimEL]: Mitochondrion. Note=Translocates from microtubules to mitochondria on loss of cell adherence.; SUBCELLULAR LOCATION: [Isoform BimL]: Mitochondrion.; SUBCELLULAR LOCATION: [Isoform BimS]: Mitochondrion.; SUBCELLULAR LOCATION: [Isoform Bim-alpha1]: Mitochondrion.
uniprot
proteins