Idh1
entrez
24479
canonical
uniprot
P41562
canonical
ensembl
ENSRNOG00000015020
resolver
ensembl
ENSRNOG00055022679
resolver
ensembl
ENSRNOG00060020894
resolver
ensembl
ENSRNOG00065026102
resolver
ensp
ENSRNOP00000020322
resolver
ensp
ENSRNOP00055031566
resolver
ensp
ENSRNOP00060029765
resolver
ensp
ENSRNOP00065036885
resolver
enst
ENSRNOT00000020322
resolver
enst
ENSRNOT00055038891
resolver
enst
ENSRNOT00060036194
resolver
enst
ENSRNOT00065045000
resolver
genesymbol
Idh1
resolver
uniprot
P80300
resolver
uniprot_entry
IDHC_RAT
resolver
uniprot_sec
P80300
resolver
amino_acid_sequence
MSRKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHDFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSKFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFANALEEVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL
uniprot
proteins
ec_number
1.1.1.42
uniprot
proteins
function
FUNCTION: Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (By similarity). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity). {ECO:0000250|UniProtKB:O75874, ECO:0000250|UniProtKB:Q9XSG3, ECO:0000269|PubMed:10521434}.
uniprot
proteins
mass_dalton
46734
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.; PTM: Acetylation at Lys-374 dramatically reduces catalytic activity. {ECO:0000250}.
uniprot
proteins
protein_family
Isocitrate and isopropylmalate dehydrogenases family
uniprot
proteins
pubmed
10521434
uniprot
proteins
pubmed
7787968
uniprot
proteins
pubmed
8083215
uniprot
proteins
sequence_length
414
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10521434, ECO:0000269|PubMed:8083215}. Peroxisome {ECO:0000269|PubMed:10521434}.
uniprot
proteins