Isg20
entrez
57444
canonical
uniprot
Q9JL16
canonical
ensembl
ENSMUSG00000039236
resolver
ensp
ENSMUSP00000040080
resolver
ensp
ENSMUSP00000112480
resolver
ensp
ENSMUSP00000112621
resolver
ensp
ENSMUSP00000113255
resolver
ensp
ENSMUSP00000198709
resolver
ensp
ENSMUSP00000198711
resolver
ensp
ENSMUSP00000361625
resolver
genesymbol
Isg20
resolver
uniprot
Q3UW00
resolver
uniprot
Q4FK39
resolver
uniprot
Q9CPZ5
resolver
uniprot_entry
ISG20_MOUSE
resolver
uniprot_entry
Q3UW00_MOUSE
resolver
uniprot_entry
Q4FK39_MOUSE
resolver
uniprot_sec
Q9CPZ5
resolver
amino_acid_sequence
MAGIPEVVAMDCEMVGLGPQRVSGLARCSIVNIHGAVLYDKYIRPEGEITDYRTQVSGVTPQHMVRATPFGEARLEILQLLKGKLVVGHDLKHDFNALKEDMSKYTIYDTSTDRLLWHEAKLQYYSRVSLRLLCKRLLHKNIQVLPGSLLGVGGCILPGTDILHLLLYVGMVRIADLRLLTPFLPPSCLACPLLPESLASARSHAVISALSSSSHLLTPLPNPSQGPQGHVDRLSGQLQDWGGSPLAPALPVSAEQLAGPLLCGRCQGHNGALQNLSATQSPARAALPWDVRLNFILIQG
uniprot
proteins
ec_number
3.1.13.1
uniprot
proteins
function
FUNCTION: Interferon-induced antiviral exoribonuclease that acts mainly on single-stranded RNA. Inhibition of several viruses does not involve the degradation of viral RNAs, but rather the inhibition of translation of viral proteins (PubMed:30232164). Exerts a translational control over a large panel of non-self RNA substrates while sparing endogenous transcripts. This activity correlates with the protein's ability to localize in cytoplasmic processing bodies (PubMed:31600344). May also act as master regulator of over hundred interferon stimulated genes leading to viral genome translation inhibition (PubMed:30232164). May play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis (By similarity). {ECO:0000250|UniProtKB:Q96AZ6, ECO:0000269|PubMed:30232164, ECO:0000269|PubMed:31600344}.
uniprot
proteins
mass_dalton
32503
uniprot
proteins
protein_family
Exonuclease superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30232164
uniprot
proteins
pubmed
31600344
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30232164}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus, Cajal body {ECO:0000269|PubMed:30232164}. Cytoplasm, P-body {ECO:0000269|PubMed:31600344}.
uniprot
proteins