Gfpt1
entrez
14583
canonical
uniprot
P47856
canonical
ensembl
ENSMUSG00000029992
resolver
ensp
ENSMUSP00000109288
resolver
genesymbol
Gfpt1
resolver
genesymbol_syn
Gfpt
resolver
uniprot
Q91XG9
resolver
uniprot
Q99LP7
resolver
uniprot
Q99MJ4
resolver
uniprot_entry
GFPT1_MOUSE
resolver
uniprot_sec
Q91XG9
resolver
uniprot_sec
Q99LP7
resolver
uniprot_sec
Q99MJ4
resolver
amino_acid_sequence
MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGLDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPNPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNWESQDVSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSTWWGSQAERGKDKKGSCGLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE
uniprot
proteins
ec_number
2.6.1.16
uniprot
proteins
function
FUNCTION: Rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose into this pathway (PubMed:23395176). Inhibited by UDP-N-acetylglucosamine (UDP-GlcNAc) through a feedback loop (PubMed:32019926). Fine-tunes the metabolic fluctuations of UDP-GlcNAc and its impacts on hyaluronan synthesis during tissue remodeling (By similarity). Via control of the HPB, regulates the availability of precursors for N- and O-linked protein glycosylation and modulates peripheral clock oscillation (PubMed:23395176). {ECO:0000250|UniProtKB:Q06210, ECO:0000269|PubMed:23395176, ECO:0000269|PubMed:32019926}.
uniprot
proteins
mass_dalton
78539
uniprot
proteins
mutagenesis
MUTAGEN 467; /note="G->E: Reduced sensitivity to UDP-GlcNAc inhibition. Increased UDP-GlcNAc levels."; /evidence="ECO:0000269|PubMed:32019926
uniprot
proteins
pathway_participation
PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1. {ECO:0000269|PubMed:32019926}.
uniprot
proteins
pubmed
11679416
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23395176
uniprot
proteins
pubmed
32019926
uniprot
proteins
pubmed
8144040
uniprot
proteins
sequence_length
697
uniprot
proteins