Grn
entrez
29143
canonical
uniprot
P23785
canonical
ensembl
ENSRNOG00000021031
resolver
ensp
ENSRNOP00000028557
resolver
ensp
ENSRNOP00000043881
resolver
ensp
ENSRNOP00000112424
resolver
enst
ENSRNOT00000028557
resolver
enst
ENSRNOT00000040472
resolver
enst
ENSRNOT00000124158
resolver
genesymbol
Grn
resolver
uniprot
A0ABK0M0I1
resolver
uniprot
F1LMP7
resolver
uniprot
G3V8V1
resolver
uniprot
Q6IN42
resolver
uniprot_entry
A0ABK0M0I1_RAT
resolver
uniprot_entry
F1LMP7_RAT
resolver
uniprot_entry
G3V8V1_RAT
resolver
uniprot_entry
GRN_RAT
resolver
uniprot_entry
Q6IN42_RAT
resolver
amino_acid_sequence
MWILVSWLALVARLVAGTQCPDGQFCPVACCLDQGGANYSCCNPLLDTWPIITSRRLDGSCQIRDHCPDGYSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHCSADGKSCSQISDSLLGAVQCPGSQFECPDSATCCIMIDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCISPTGTHPLLKKFPAQRTNRAVASFSVVCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCISKDYTTDLMTKLPGYPVNEVKCDLEVSCPDGYTCCRLNTGAWGCCPFTKAVCCEDHIHCCPAGFQCHTETGTCELGVLQVPWMKKVTASLSLPDPQILKNDVPCDDFSSCPSNNTCCRLSSGDWGCCPMPEAVCCLDHQHCCPQGFKCMDEGYCQKGDRMVAGLEKMPVRQTTLLQHGDIGCDQHTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTCEKDAGSVQPSMDLTFGSKVGNVECGAGHFCHDNQSCCKDSQGGWACCPYVKGVCCRDGRHCCPIGFHCSAKGTKCLRKKTPRWDILLRDPAPRPLL
uniprot
proteins
function
FUNCTION: Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (By similarity). Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes (By similarity). Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB (By similarity). In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (By similarity). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (By similarity). {ECO:0000250|UniProtKB:P28798, ECO:0000250|UniProtKB:P28799}.; FUNCTION: [Granulin-3]: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. {ECO:0000250|UniProtKB:P28799}.; FUNCTION: [Granulin-7]: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity. {ECO:0000250|UniProtKB:P28799}.
uniprot
proteins
mass_dalton
63370
uniprot
proteins
post_translational_modification
PTM: Cleaved by ELANE; proteolysis is blocked by SLPI and is concentration- and time-dependent and induces CXCL8/IL-8 production; granulin-3 and granulin-4 are resistant to ELANE. Cleaved by CTSL in lysosome thus regulating the maturation and turnover of progranulin within the lysosome. {ECO:0000250|UniProtKB:P28799}.
uniprot
proteins
protein_family
Granulin family
uniprot
proteins
pubmed
1618805
uniprot
proteins
pubmed
2236009
uniprot
proteins
pubmed
2268320
uniprot
proteins
pubmed
8243292
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P28799}. Lysosome {ECO:0000250|UniProtKB:P28799}. Note=Endocytosed by SORT1 and delivred to lysosomes. Targeted to lysosome by PSAP via M6PR and LRP1, in both biosynthetic and endocytic pathways (By similarity). Co-localized with GBA1 in the intracellular trafficking compartments until to lysosome (By similarity). {ECO:0000250|UniProtKB:P28798, ECO:0000250|UniProtKB:P28799}.
uniprot
proteins