IL18BP
entrez
10068
canonical
uniprot
O95998
canonical
ensembl
ENSG00000137496
resolver
ensp
ENSP00000338723
resolver
ensp
ENSP00000377306
resolver
ensp
ENSP00000377308
resolver
ensp
ENSP00000377310
resolver
ensp
ENSP00000384212
resolver
ensp
ENSP00000434717
resolver
ensp
ENSP00000434835
resolver
ensp
ENSP00000480621
resolver
ensp
ENSP00000513973
resolver
ensp
ENSP00000513975
resolver
ensp
ENSP00000575120
resolver
ensp
ENSP00000575121
resolver
ensp
ENSP00000575125
resolver
ensp
ENSP00000618828
resolver
enst
ENST00000497194
resolver
enst
ENST00000531053
resolver
genesymbol
IL18BP
resolver
hgnc
HGNC:5987
resolver
uniprot
A0A024R5M6
resolver
uniprot
B3KUZ0
resolver
uniprot
B7WPK4
resolver
uniprot
G3V1C5
resolver
uniprot
O95993
resolver
uniprot
O96027
resolver
uniprot
Q9NZA9
resolver
uniprot
Q9UBR7
resolver
uniprot_entry
G3V1C5_HUMAN
resolver
uniprot_entry
I18BP_HUMAN
resolver
uniprot_sec
A0A024R5M6
resolver
uniprot_sec
B3KUZ0
resolver
uniprot_sec
B7WPK4
resolver
uniprot_sec
O95993
resolver
uniprot_sec
O96027
resolver
uniprot_sec
Q9NZA9
resolver
uniprot_sec
Q9UBR7
resolver
amino_acid_sequence
MTMRHNWTPDLSPLWVLLLCAHVVTLLVRATPVSQTTTAATASVRSTKDPCPSQPPVFPAAKQCPALEVTWPEVEVPLNGTLSLSCVACSRFPNFSILYWLGNGSFIEHLPGRLWEGSTSRERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQRHVVLAQLWAGLRATLPPTQEALPSSHSSPQQQG
uniprot
proteins
disease_involvement
DISEASE: Hepatitis, fulminant viral (FVH) [MIM:618549]: An autosomal recessive form of fulminant viral hepatitis, a disease that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. FVH is characterized by severe liver destruction in the absence of a preexisting liver disorder, leading to encephalopathy within 8 weeks of the onset of the first symptoms. {ECO:0000269|PubMed:31213488}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. {ECO:0000269|PubMed:10023777, ECO:0000269|PubMed:10655506, ECO:0000269|PubMed:31213488}.
uniprot
proteins
mass_dalton
21099
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc4. {ECO:0000269|PubMed:22171320}.
uniprot
proteins
pubmed
10023777
uniprot
proteins
pubmed
10094485
uniprot
proteins
pubmed
10329540
uniprot
proteins
pubmed
10655506
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
22171320
uniprot
proteins
pubmed
31213488
uniprot
proteins
sequence_length
194
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31213488}.
uniprot
proteins