Dtnb
entrez
13528
canonical
uniprot
O70585
canonical
ensembl
ENSMUSG00000071454
resolver
ensp
ENSMUSP00000077085
resolver
ensp
ENSMUSP00000126194
resolver
ensp
ENSMUSP00000133927
resolver
ensp
ENSMUSP00000134392
resolver
ensp
ENSMUSP00000271852
resolver
ensp
ENSMUSP00000271853
resolver
ensp
ENSMUSP00000271854
resolver
ensp
ENSMUSP00000271857
resolver
ensp
ENSMUSP00000271859
resolver
ensp
ENSMUSP00000271860
resolver
ensp
ENSMUSP00000271861
resolver
ensp
ENSMUSP00000271862
resolver
ensp
ENSMUSP00000340693
resolver
enst
ENSMUST00000077930
resolver
enst
ENSMUST00000173199
resolver
genesymbol
Dtnb
resolver
uniprot
E9Q0F2
resolver
uniprot
F7APY8
resolver
uniprot
G3UZ87
resolver
uniprot
O70563
resolver
uniprot
Q8K0N0
resolver
uniprot
Q9CTZ1
resolver
uniprot_entry
DTNB_MOUSE
resolver
uniprot_entry
F7APY8_MOUSE
resolver
uniprot_entry
G3UZ87_MOUSE
resolver
uniprot_entry
Q8K0N0_MOUSE
resolver
uniprot_sec
E9Q0F2
resolver
uniprot_sec
O70563
resolver
uniprot_sec
Q9CTZ1
resolver
amino_acid_sequence
MIEEGGNKRKTMAEKRQLFIEMRAQNFDVIRLSTYRTACKLRFVQKRCNLHLVDIWNMIEAFRDNGLNTLDHSTEISVSRLETVISSIYYQLNKRLPSTHQISVEQSISLLLNFMVAAYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRYIFSQMSDSNGLMMFGKLDQFLKEALKLPTAVFEGPSFGYTEHAVRTCFPQQKKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVFHPVECSYCHCESMMGFRYRCQQCHNYQLCQNCFWRGHASGAHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPSREPPHPVFPEQPEKPLDLAHLVPPRPLTNMNDTVVSHMSSGVPTPTKRLQYSQDMPNLLADEHALIASYVARLQHCTRVLDSPSRLDEEHRLIARYAARLAAEAGNMTRPPTDASFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPMLLAELRLLRQRKDELEQRMSALQESRRELMVQLEGLMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHGPQDSLSGVGGDVQEAFAQGTRRNLRNDLLVAADSITNTMSSLVKELHSGAEAEEQAGTEKTREGLPPRGTFLSVFLLHTWTKLAGCQTHSTSRERSQAYGKWGGTA
uniprot
proteins
function
FUNCTION: Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (PubMed:11585924). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:20530487). May be required for proper maturation and function of a subset of inhibitory synapses (PubMed:16540561). {ECO:0000269|PubMed:11585924, ECO:0000269|PubMed:16540561, ECO:0000269|PubMed:20530487}.
uniprot
proteins
mass_dalton
74399
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="T->A: Does not affect interaction with Kif5A."; /evidence="ECO:0000269|PubMed:22978324"; MUTAGEN 11; /note="T->D: Reduces interaction with Kif5A."; /evidence="ECO:0000269|PubMed:22978324
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA (PubMed:17610895). Phosphorylation at Thr-11 alters the interaction with KIF5A (PubMed:22978324). {ECO:0000269|PubMed:17610895, ECO:0000269|PubMed:22978324}.
uniprot
proteins
protein_family
Dystrobrevin subfamily
uniprot
proteins
protein_family
Dystrophin family
uniprot
proteins
pubmed
10545507
uniprot
proteins
pubmed
10893187
uniprot
proteins
pubmed
11316798
uniprot
proteins
pubmed
11585924
uniprot
proteins
pubmed
14600269
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16540561
uniprot
proteins
pubmed
17265465
uniprot
proteins
pubmed
17610895
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20530487
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22978324
uniprot
proteins
pubmed
9419360
uniprot
proteins
pubmed
9540997
uniprot
proteins
pubmed
9799833
uniprot
proteins
sequence_length
659
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20530487}. Postsynaptic density {ECO:0000250|UniProtKB:P84060}. Cell projection, dendrite {ECO:0000269|PubMed:11585924, ECO:0000269|PubMed:16540561}. Basal cell membrane {ECO:0000269|PubMed:10893187}. Postsynapse {ECO:0000269|PubMed:16540561}. Nucleus {ECO:0000269|PubMed:20530487}. Note=Localized at inhibitory synapses on the dendrites of cerebellar Purkinje cells. {ECO:0000269|PubMed:16540561}.
uniprot
proteins