Timd2
entrez
171284
canonical
uniprot
Q8R183
canonical
ensembl
ENSMUSG00000040413
resolver
ensp
ENSMUSP00000060891
resolver
ensp
ENSMUSP00000104848
resolver
ensp
ENSMUSP00000131540
resolver
ensp
ENSMUSP00000363282
resolver
enst
ENSMUST00000055102
resolver
enst
ENSMUST00000109225
resolver
enst
ENSMUST00000169584
resolver
genesymbol
Timd2
resolver
genesymbol_syn
Tim2
resolver
uniprot
A8C1R4
resolver
uniprot
F7BLX6
resolver
uniprot
Q8VBW0
resolver
uniprot_entry
A8C1R4_MOUSE
resolver
uniprot_entry
F7BLX6_MOUSE
resolver
uniprot_entry
TIMD2_MOUSE
resolver
uniprot_sec
Q8VBW0
resolver
amino_acid_sequence
MNQIQVFISGLILLLPGAVESHTAVQGLAGHPVTLPCIYSTHLGGIVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSLYQLKGNISEGNVSLTIENTVVGDGGPYCCVVEIPGAFHFVDYMLEVKPEISTSPPTRPTATGRPTTISTRSTHVPTSTRVSTSTSPTPAHTETYKPEATTFYPDQTTAEVTETLPDTPADWHNTVTSSDDPWDDNTEVIPPQKPQKNLNKGFYVGISIAALLILMLLSTMVITRYVVMKRKSESLSFVAFPISKIGASPKKVVERTRCEDQVYIIEDTPYPEEES
uniprot
proteins
function
FUNCTION: Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin (PubMed:16203866, PubMed:33065090). Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed:16043519, PubMed:21886823). Plays also an important role in the regulation of Th2 immunity (PubMed:16043519). Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed:12374982). {ECO:0000269|PubMed:12374982, ECO:0000269|PubMed:16043519, ECO:0000269|PubMed:16203866, ECO:0000269|PubMed:21886823, ECO:0000269|PubMed:33065090}.
uniprot
proteins
mass_dalton
33504
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
TIM family
uniprot
proteins
pubmed
11725301
uniprot
proteins
pubmed
12374982
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16043519
uniprot
proteins
pubmed
16203866
uniprot
proteins
pubmed
17363299
uniprot
proteins
pubmed
21886823
uniprot
proteins
pubmed
33065090
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17363299, ECO:0000269|PubMed:21886823}; Single-pass type I membrane protein {ECO:0000269|PubMed:17363299}.
uniprot
proteins
transmembrane_region
TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins