Rab4b
entrez
50866
canonical
uniprot
P51146
canonical
ensembl
ENSRNOG00000001500
resolver
ensembl
ENSRNOG00055033560
resolver
ensembl
ENSRNOG00060032248
resolver
ensembl
ENSRNOG00065033404
resolver
ensp
ENSRNOP00000002052
resolver
ensp
ENSRNOP00055047853
resolver
ensp
ENSRNOP00060046233
resolver
ensp
ENSRNOP00065047279
resolver
enst
ENSRNOT00000002052
resolver
enst
ENSRNOT00055058013
resolver
enst
ENSRNOT00060055897
resolver
enst
ENSRNOT00065057438
resolver
genesymbol
Rab4b
resolver
uniprot_entry
RAB4B_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILCGNKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDPERMGSGIQYGDISLRQLRQPRSAQAVAPQPCGC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB4B mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB14 (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). {ECO:0000250|UniProtKB:P20338, ECO:0000250|UniProtKB:P61018, ECO:0000250|UniProtKB:Q91ZR1}.
uniprot
proteins
mass_dalton
23629
uniprot
proteins
post_translational_modification
PTM: Serotonylation of Gln-67 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity. {ECO:0000250|UniProtKB:Q91ZR1}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
sequence_length
213
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P61018}; Lipid-anchor {ECO:0000250|UniProtKB:P61018}; Cytoplasmic side {ECO:0000250|UniProtKB:P61018}. Early endosome membrane {ECO:0000250|UniProtKB:P61018}; Lipid-anchor {ECO:0000250|UniProtKB:P61018}; Cytoplasmic side {ECO:0000250|UniProtKB:P61018}.
uniprot
proteins