Ddx20
entrez
53975
canonical
uniprot
Q9JJY4
canonical
ensembl
ENSMUSG00000027905
resolver
ensp
ENSMUSP00000088176
resolver
ensp
ENSMUSP00000213508
resolver
enst
ENSMUST00000090680
resolver
genesymbol
Ddx20
resolver
genesymbol_syn
Dp103
resolver
genesymbol_syn
Gemin3
resolver
uniprot
Q059Z6
resolver
uniprot
Q9JIK4
resolver
uniprot_entry
DDX20_MOUSE
resolver
uniprot_sec
Q059Z6
resolver
uniprot_sec
Q9JIK4
resolver
amino_acid_sequence
MAAAAFEVPAALTTSESTMAAERAAAPVQAVEPTPASPWTQRTAHDIGGPRTRTGDVVLAEPADFESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIAVQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKKCHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGSFQEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFVRLNPSDPSLIGLKQYYQVVNSYPLAHKIFEEKTQHLQELFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCRGEEENMMMKIAQKCNINLLPLPDPIPPGLMEECLNWDVEVKAAMHTYSSPTVATQSPKKQVQKLERAFQSQRTPGNQTPSPRNTSASALSARPKHSKPKLPVKSHSECGVLEKAAPPQESGCPAQLEEQVKNSVQTSVEDSSSNSQHQAKDSSPGSLPKIPCLSSFKVHQPSTLTFAELVDDYEHYIKEGLEKPVEIIRHYTGPEAQTGNPQNGFVRNRVSEDRAQMLVSSSQSGDSESDSDSCSSRTSSQSKGNKSYLEGSSDTQLKDTECTPVGGPLSLEQVQNGNDTPTQVEYQEAPETQVKARHKEGANQRSKQSRRNPARRSSYRVQSEPQEESWYDCHRETTASFSDTYQDYEEYWRAYYRAWQEYYAAASHSYYWNAQRHPSWMAAYHMNTVYLQEMMRGNQ
uniprot
proteins
ec_number
3.6.1.15
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs) (By similarity). {ECO:0000250|UniProtKB:Q9UHI6}.
uniprot
proteins
mass_dalton
91710
uniprot
proteins
protein_family
DDX20 subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
10767334
uniprot
proteins
pubmed
11145740
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16153597
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
825
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UHI6}. Nucleus, gem {ECO:0000250|UniProtKB:Q9UHI6}. Note=Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems). {ECO:0000250|UniProtKB:Q9UHI6}.
uniprot
proteins