Q07303
uniprot
Q07303
canonical
amino_acid_sequence
MDQLRVARWPRVSPLCLLLAGAAWASSPSLPDPKFESKAALLASRGSEELLCFTQRLEDLVCFWEEAANSGMGFNYSFSYQLEGESRKSCRLHQAPTVRGSMRFWCSLPTADTSSFVPLELQVTEASGSPRYHRIIHINEVVLLDAPAGLLARRAEEGSHVVLRWLPPPGAPMTTHIRYEVDVSAGNRAGGTQRVEVLEGRTECVLSNLRGGTRYTFAVRARMAEPSFSGFWSAWSEPASLLTASDLDPLILTLSLILVLISLLLTVLALLSHRRALRQKIWPGIPSPENEFEGLFTTHKGNFQLWLLQRDGCLWWSPSSPFPEDPPAHLEVLSERRWGVTQAGDAGAEDKGPLLEPVGSERAQDTYLVLDEWLLPRCPCSENLSGPGDSVDPATMDEGSETSSCPSDLASKPRPEGTSPSSFEYTILDPSSKLLCPRALPPELPPTPPHLKYLYLVVSDSGISTDYSSGGSQGVHGDSSDGPYSHPYENSLVPDTEPLRPSYVACS
uniprot
proteins
function
FUNCTION: Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation (By similarity). Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade (By similarity). In some cell types, can also activate STAT1 and STAT3 (By similarity). May also activate the LYN tyrosine kinase (By similarity). {ECO:0000250|UniProtKB:P14753, ECO:0000250|UniProtKB:P19235}.; FUNCTION: Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling. {ECO:0000250|UniProtKB:P19235}.
uniprot
proteins
mass_dalton
55500
uniprot
proteins
post_translational_modification
PTM: On EPO stimulation, phosphorylated on C-terminal tyrosine residues by JAK2 (By similarity). The phosphotyrosine motifs are also recruitment sites for several SH2-containing proteins and adapter proteins which mediate cell proliferation (By similarity). Phosphorylation on Tyr-455 is required for PTPN6 interaction, Tyr-425 for PTPN11 (By similarity). Tyr-425 is also required for SOCS3 binding, but Tyr-453/Tyr-455 motif is the preferred binding site (By similarity). {ECO:0000250|UniProtKB:P14753, ECO:0000250|UniProtKB:P19235}.; PTM: Ubiquitinated by the ECS(SOCS2) complex following ligand-binding and phosphorylation by JAK2, leading to its degradation by the proteasome (By similarity). Regulation by the ECS(SOCS2) complex acts as a negative feedback loop of erythropoietin-mediated signaling pathway (By similarity). Ubiquitination at Lys-280 mediates receptor internalization, whereas ubiquitination at Lys-452 promotes trafficking of activated receptors to the lysosomes for degradation (By similarity). Ubiquitinated by NOSIP; appears to be either multi-monoubiquitinated or polyubiquitinated (By similarity). Ubiquitination mediates proliferation and survival of EPO-dependent cells (By similarity). {ECO:0000250|UniProtKB:P14753, ECO:0000250|UniProtKB:P19235}.
uniprot
proteins
protein_family
Type 1 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
7684373
uniprot
proteins
pubmed
9029168
uniprot
proteins
sequence_length
507
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P14753}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 250..272; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins