KRT19
entrez
3880
canonical
uniprot
P08727
canonical
ensembl
ENSG00000171345
resolver
ensp
ENSP00000355124
resolver
enst
ENST00000361566
resolver
genesymbol
KRT19
resolver
hgnc
HGNC:6436
resolver
uniprot
B2R874
resolver
uniprot
Q5XG83
resolver
uniprot
Q6NW33
resolver
uniprot
Q7L5M9
resolver
uniprot
Q96A53
resolver
uniprot
Q96FV1
resolver
uniprot
Q9BYF9
resolver
uniprot
Q9P1Y4
resolver
uniprot_entry
K1C19_HUMAN
resolver
uniprot_sec
B2R874
resolver
uniprot_sec
Q5XG83
resolver
uniprot_sec
Q6NW33
resolver
uniprot_sec
Q7L5M9
resolver
uniprot_sec
Q96A53
resolver
uniprot_sec
Q96FV1
resolver
uniprot_sec
Q9BYF9
resolver
uniprot_sec
Q9P1Y4
resolver
amino_acid_sequence
MTSYSYRQSSATSSFGGLGGGSVRFGPGVAFRAPSIHGGSGGRGVSVSSARFVSSSSSGAYGGGYGGVLTASDGLLAGNEKLTMQNLNDRLASYLDKVRALEAANGELEVKIRDWYQKQGPGPSRDYSHYYTTIQDLRDKILGATIENSRIVLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARTDLEMQIEGLKEELAYLKKNHEEEISTLRGQVGGQVSVEVDSAPGTDLAKILSDMRSQYEVMAEQNRKDAEAWFTSRTEELNREVAGHTEQLQMSRSEVTDLRRTLQGLEIELQSQLSMKAALEDTLAETEARFGAQLAHIQALISGIEAQLGDVRADSERQNQEYQRLMDIKSRLEQEIATYRSLLEGQEDHYNNLSASKVL
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in epithelial cells. Forms intermediate filaments by heterodimerizing with the type II keratin KRT8, providing mechanical integrity to epithelial cells (PubMed:16000376). Integrates into the intermediate filament network of skeletal muscle fibers alongside desmin and KRT18, contributing to force transmission (By similarity). Specifically interacts with the actin-binding domain of dystrophin, helping to link the contractile apparatus to dystrophin at the costameres of striated muscle (PubMed:16000376). {ECO:0000250|UniProtKB:P19001, ECO:0000269|PubMed:16000376}.
uniprot
proteins
mass_dalton
44106
uniprot
proteins
mutagenesis
MUTAGEN 10; /note="S->A: No effect on phosphorylation; no functional effect."; /evidence="ECO:0000269|PubMed:10212274"; MUTAGEN 35; /note="S->A: Abolishes phosphorylation; induces perinuclear collapse or short cytoplasmic filaments."; /evidence="ECO:0000269|PubMed:10212274
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
10212274
uniprot
proteins
pubmed
10623642
uniprot
proteins
pubmed
10809736
uniprot
proteins
pubmed
11682035
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15846844
uniprot
proteins
pubmed
16000376
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
21049038
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
2447559
uniprot
proteins
pubmed
2448790
uniprot
proteins
pubmed
2468493
uniprot
proteins
pubmed
2469734
uniprot
proteins
sequence_length
400
uniprot
proteins