Eda
entrez
13607
canonical
uniprot
O54693
canonical
ensembl
ENSMUSG00000059327
resolver
ensp
ENSMUSP00000071397
resolver
ensp
ENSMUSP00000109405
resolver
ensp
ENSMUSP00000109406
resolver
ensp
ENSMUSP00000109407
resolver
ensp
ENSMUSP00000109408
resolver
ensp
ENSMUSP00000109409
resolver
ensp
ENSMUSP00000109410
resolver
ensp
ENSMUSP00000109411
resolver
ensp
ENSMUSP00000109413
resolver
enst
ENSMUST00000071453
resolver
enst
ENSMUST00000113775
resolver
enst
ENSMUST00000113776
resolver
enst
ENSMUST00000113777
resolver
enst
ENSMUST00000113781
resolver
enst
ENSMUST00000113783
resolver
genesymbol
Eda
resolver
genesymbol_syn
Ed1
resolver
genesymbol_syn
Ta
resolver
genesymbol_syn
Tnlg7c
resolver
uniprot
A0A0U5J8Q0
resolver
uniprot
B7ZMT7
resolver
uniprot
F6VGA6
resolver
uniprot
F6VGD1
resolver
uniprot
F8WH55
resolver
uniprot
O35705
resolver
uniprot
Q1L2D6
resolver
uniprot
Q1L2D8
resolver
uniprot
Q1L2D9
resolver
uniprot
Q1L2E0
resolver
uniprot
Q3UV69
resolver
uniprot
Q9QWJ8
resolver
uniprot
Q9QZ01
resolver
uniprot
Q9QZ02
resolver
uniprot_entry
A0A0U5J8Q0_MOUSE
resolver
uniprot_entry
EDA_MOUSE
resolver
uniprot_entry
F6VGA6_MOUSE
resolver
uniprot_entry
F6VGD1_MOUSE
resolver
uniprot_entry
F8WH55_MOUSE
resolver
uniprot_entry
Q1L2D6_MOUSE
resolver
uniprot_entry
Q1L2D8_MOUSE
resolver
uniprot_entry
Q1L2D9_MOUSE
resolver
uniprot_entry
Q1L2E0_MOUSE
resolver
uniprot_entry
Q3UV69_MOUSE
resolver
uniprot_sec
B7ZMT7
resolver
uniprot_sec
O35705
resolver
uniprot_sec
Q9QWJ8
resolver
uniprot_sec
Q9QZ01
resolver
uniprot_sec
Q9QZ02
resolver
amino_acid_sequence
MGYPEVERREPLPAAAPRERGSQGCGCRGAPARAGEGNSCRLFLGFFGLSLALHLLTLCCYLELRSELRRERGTESRLGGPGAPGTSGTLSSPGSLDPVGPITRHLGQPSFQQQPLEPGEDPLPPDSQDRHQMALLNFFFPDEKAYSEEESRRVRRNKRSKSGEGADGPVKNKKKGKKAGPPGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKTGTRENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFIYSQVEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKMVHADISINMSKHTTFFGAIRLGEAPAS
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Eda are the cause of the tabby phenotype in mice (the equivalent of anhidrotic ectodermal dysplasia in humans). The disease is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
uniprot
proteins
function
FUNCTION: Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform TAA binds only to the receptor EDAR, while isoform TA-A2 binds exclusively to the receptor EDA2R (By similarity). May also play a role in cell adhesion (PubMed:10534613). {ECO:0000250|UniProtKB:Q92838, ECO:0000269|PubMed:10534613}.; FUNCTION: Isoform TAA binds only to the receptor EDAR, while isoform TA-A2 binds exclusively to the receptor EDA2R. {ECO:0000250|UniProtKB:Q92838}.; FUNCTION: Isoform TA-A2 binds exclusively to the receptor EDA2R. {ECO:0000250|UniProtKB:Q92838}.
uniprot
proteins
mass_dalton
41603
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10534613}.; PTM: Processing by furin produces a secreted form. {ECO:0000250|UniProtKB:Q92838}.
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
10534613
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9285798
uniprot
proteins
pubmed
9371801
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10534613}; Single-pass type II membrane protein {ECO:0000269|PubMed:10534613}.; SUBCELLULAR LOCATION: [Ectodysplasin-A, secreted form]: Secreted {ECO:0000250|UniProtKB:Q92838}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..62; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins