PPA1
entrez
5464
canonical
uniprot
Q15181
canonical
ensembl
ENSG00000180817
resolver
ensp
ENSP00000362329
resolver
enst
ENST00000373232
resolver
genesymbol
HEL-S-66p
resolver
genesymbol
PPA1
resolver
genesymbol_syn
IOPPP
resolver
genesymbol_syn
PP
resolver
genesymbol_syn
PPA1
resolver
hgnc
HGNC:9226
resolver
uniprot
Q2M348
resolver
uniprot
Q5SQT7
resolver
uniprot
Q6P7P4
resolver
uniprot
Q9UQJ5
resolver
uniprot
Q9Y5B1
resolver
uniprot
V9HWB5
resolver
uniprot_entry
IPYR_HUMAN
resolver
uniprot_entry
V9HWB5_HUMAN
resolver
uniprot_sec
Q2M348
resolver
uniprot_sec
Q5SQT7
resolver
uniprot_sec
Q6P7P4
resolver
uniprot_sec
Q9UQJ5
resolver
uniprot_sec
Q9Y5B1
resolver
amino_acid_sequence
MSGFSTEERAAPFSLEYRVFLKNEKGQYISPFHDIPIYADKDVFHMVVEVPRWSNAKMEIATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPIDVCEIGSKVCARGEIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYNDINDVKRLKPGYLEATVDWFRRYKVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGISCMNTTLSESPFKCDPDAARAIVDALPPPCESACTVPTDVDKWFHHQKN
uniprot
proteins
ec_number
3.6.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of inorganic diphosphate into two phosphate molecules (PubMed:33036755, PubMed:38428647). Has MAP kinase serine/threonine phosphatase activity toward c-Jun N-terminal kinase (JNK) and, in neuronal cells, is involved in the negative regulation of neurite growth via JNK dephosphorylation (By similarity). {ECO:0000250|UniProtKB:Q9D819, ECO:0000269|PubMed:33036755, ECO:0000269|PubMed:38428647}.
uniprot
proteins
mass_dalton
32660
uniprot
proteins
mutagenesis
MUTAGEN 52; /note="R->A: Does not form homodimers; when associated with A-281."; /evidence="ECO:0000269|PubMed:33036755"; MUTAGEN 116; /note="D->A: Loss of inorganic diphosphate phosphatase activity. Loss of inorganic diphosphate phosphatase activity; when associated with A-118, A-119 and A-121."; /evidence="ECO:0000269|PubMed:33036755, ECO:0000269|PubMed:38428647"; MUTAGEN 118; /note="D->A: Loss of inorganic diphosphate phosphatase activity. Loss of inorganic diphosphate phosphatase activity; when associated with A-116, A-119 and A-121."; /evidence="ECO:0000269|PubMed:33036755, ECO:0000269|PubMed:38428647"; MUTAGEN 119; /note="P->A: Loss of inorganic diphosphate phosphatase activity. Loss of inorganic diphosphate phosphatase activity; when associated with A-116, A-118 and A-121."; /evidence="ECO:0000269|PubMed:33036755, ECO:0000269|PubMed:38428647"; MUTAGEN 121; /note="D->A: Severely decreased inorganic diphosphate phosphatase activity. Results in over 100-fold decrease of affinity for diphosphate. Loss of inorganic diphosphate phosphatase activity; when associated with A-116, A-118 and A-119."; /evidence="ECO:0000269|PubMed:33036755, ECO:0000269|PubMed:38428647"; MUTAGEN 281; /note="D->A: Does not form homodimers; when associated with A-52."; /evidence="ECO:0000269|PubMed:33036755
uniprot
proteins
protein_family
PPase family
uniprot
proteins
pubmed
10542310
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
33036755
uniprot
proteins
pubmed
33583053
uniprot
proteins
pubmed
38428647
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins