Kcnd3
entrez
65195
canonical
uniprot
Q62897
canonical
ensembl
ENSRNOG00000014686
resolver
ensp
ENSRNOP00000019997
resolver
ensp
ENSRNOP00000049111
resolver
enst
ENSRNOT00000019997
resolver
enst
ENSRNOT00000051835
resolver
genesymbol
Kcnd3
resolver
uniprot
A0A0G2JSN5
resolver
uniprot
A0A0G2JSW5
resolver
uniprot
O08723
resolver
uniprot
P70622
resolver
uniprot
Q63286
resolver
uniprot
Q99P42
resolver
uniprot_entry
A0A0G2JSN5_RAT
resolver
uniprot_entry
A0A0G2JSW5_RAT
resolver
uniprot_entry
KCND3_RAT
resolver
uniprot_sec
O08723
resolver
uniprot_sec
P70622
resolver
uniprot_sec
Q63286
resolver
uniprot_sec
Q99P42
resolver
amino_acid_sequence
MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNESENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHSGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSITSNVVKVSVL
uniprot
proteins
function
FUNCTION: Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart (PubMed:17057713, PubMed:8734615, PubMed:8831489, PubMed:9001401, PubMed:9450548). In cardiomyocytes, may generate the transient outward potassium current I(To) (Probable). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (Probable). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation (PubMed:17057713, PubMed:8734615, PubMed:8831489, PubMed:9001401, PubMed:9450548). Channel properties are modulated by interactions with regulatory subunits (PubMed:10676964, PubMed:17057713). Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation (PubMed:10676964, PubMed:17057713). Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics (By similarity). {ECO:0000250|UniProtKB:Q9UK17, ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:17057713, ECO:0000269|PubMed:8734615, ECO:0000269|PubMed:8831489, ECO:0000269|PubMed:9001401, ECO:0000269|PubMed:9450548, ECO:0000305|PubMed:8734615, ECO:0000305|PubMed:8831489}.
uniprot
proteins
mass_dalton
73513
uniprot
proteins
post_translational_modification
PTM: Regulated through phosphorylation at Ser-569 by CaMK2D. {ECO:0000269|PubMed:15456698}.
uniprot
proteins
protein_family
D (Shal) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv4.3/KCND3 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10676964
uniprot
proteins
pubmed
11427525
uniprot
proteins
pubmed
11805342
uniprot
proteins
pubmed
12006572
uniprot
proteins
pubmed
15456698
uniprot
proteins
pubmed
17057713
uniprot
proteins
pubmed
19213956
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8734615
uniprot
proteins
pubmed
8831489
uniprot
proteins
pubmed
9001401
uniprot
proteins
pubmed
9314834
uniprot
proteins
pubmed
9450548
uniprot
proteins
sequence_length
655
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12006572, ECO:0000269|PubMed:19213956}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000269|PubMed:19213956}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:19213956}. Note=Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression. {ECO:0000269|PubMed:12006572}.
uniprot
proteins
transmembrane_region
TRANSMEM 183..204; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:Q9UK17"; TRANSMEM 224..246; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:Q9UK17"; TRANSMEM 254..277; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:Q9UK17"; TRANSMEM 284..306; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:Q9UK17"; TRANSMEM 319..343; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:Q9UK17"; TRANSMEM 378..400; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:Q9UK17
uniprot
proteins