CPEB1
entrez
64506
canonical
uniprot
Q9BZB8
canonical
ensembl
ENSG00000214575
resolver
ensembl
ENSG00000277445
resolver
ensp
ENSP00000477557
resolver
ensp
ENSP00000477715
resolver
ensp
ENSP00000478598
resolver
ensp
ENSP00000479625
resolver
ensp
ENSP00000481010
resolver
ensp
ENSP00000483590
resolver
ensp
ENSP00000483857
resolver
ensp
ENSP00000484549
resolver
ensp
ENSP00000507835
resolver
ensp
ENSP00000572848
resolver
ensp
ENSP00000572849
resolver
ensp
ENSP00000572850
resolver
ensp
ENSP00000572851
resolver
ensp
ENSP00000679588
resolver
enst
ENST00000614918
resolver
enst
ENST00000684509
resolver
enst
ENST00000902789
resolver
enst
ENST00000902790
resolver
enst
ENST00000902791
resolver
enst
ENST00000902792
resolver
genesymbol
CPEB1
resolver
genesymbol_syn
CPEB
resolver
hgnc
HGNC:21744
resolver
uniprot
A0A087WXG7
resolver
uniprot
B4DWY2
resolver
uniprot
B7Z6C6
resolver
uniprot
Q86W46
resolver
uniprot
Q8IV41
resolver
uniprot
Q9BZB7
resolver
uniprot
Q9H8V5
resolver
uniprot_entry
A0A087WXG7_HUMAN
resolver
uniprot_entry
B4DWY2_HUMAN
resolver
uniprot_entry
CPEB1_HUMAN
resolver
uniprot_sec
B7Z6C6
resolver
uniprot_sec
Q86W46
resolver
uniprot_sec
Q8IV41
resolver
uniprot_sec
Q9BZB7
resolver
uniprot_sec
Q9H8V5
resolver
amino_acid_sequence
MALSLEEEAGRIKDCWDNQEAPALSTCSNANIFRRINAILDNSLDFSRVCTTPINRGIHDHLPDFQDSEETVTSRMLFPTSAQESSRGLPDANDLCLGLQSLSLTGWDRPWSTQDSDSSAQSSTHSVLSMLHNPLGNVLGKPPLSFLPLDPLGSDLVDKFPAPSVRGSRLDTRPILDSRSSSPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLSLSGGGPRDPLKMGVGSRMDQEQAALAAVTPSPTSASKRWPGASVWPSWDLLEAPKDPFSIEREARLHRQAAAVNEATCTWSGQLPPRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGKDGKHPRCPPKGNMPKGYVYLVFELEKSVRSLLQACSHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSNFVRSPSQRLDPSRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLKAVSAAFVEIKTTKFTKKVQIDPYLEDSLCHICSSQPGPFFCRDQVCFKYFCRSCWHWRHSMEGLRHHSPLMRNQKNRDSS
uniprot
proteins
function
FUNCTION: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195). {ECO:0000250|UniProtKB:P70166, ECO:0000269|PubMed:15731006, ECO:0000269|PubMed:15966895, ECO:0000269|PubMed:24990967, ECO:0000269|PubMed:26398195}.
uniprot
proteins
mass_dalton
62595
uniprot
proteins
mutagenesis
MUTAGEN 172; /note="T->A: Does not affect its localization."; /evidence="ECO:0000269|PubMed:15731006"; MUTAGEN 172; /note="T->D: Does not affect its localization."; /evidence="ECO:0000269|PubMed:15731006"; MUTAGEN 314; /note="F->A: Abolishes stress granule assembly and correct localization in dcp1 bodies."; /evidence="ECO:0000269|PubMed:15731006"; MUTAGEN 545; /note="H->A: Abolishes stress granule assembly and correct localization in dcp1 bodies."; /evidence="ECO:0000269|PubMed:15731006
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine/threonine residues by AURKA within positions 166 and 197. Phosphorylation and dephosphorylation on Thr-172 regulates cytoplasmic polyadenylation and translation of CPE-containing mRNAs. Phosphorylation on Thr-172 by AURKA and CAMK2A activates CPEB1. Phosphorylation on Thr-172 may be promoted by APLP1. Phosphorylation increases binding to RNA (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
RRM CPEB family
uniprot
proteins
pubmed
11223249
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15731006
uniprot
proteins
pubmed
15966895
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18923137
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23500490
uniprot
proteins
pubmed
24990967
uniprot
proteins
pubmed
26063658
uniprot
proteins
pubmed
26398195
uniprot
proteins
pubmed
26456073
uniprot
proteins
pubmed
28383716
uniprot
proteins
sequence_length
566
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18923137, ECO:0000269|PubMed:28383716}. Nucleus {ECO:0000269|PubMed:18923137}. Cytoplasm, P-body. Cytoplasmic granule. Synapse. Membrane. Postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Continuously shuttling between nucleus and cytoplasm (PubMed:18923137). Also found in stress granules. Recruited to stress granules (SGs) upon arsenite treatment. In dendrites (By similarity). Localizes in synaptosomes at dendritic synapses of neurons (By similarity). Strongly enriched in postsynaptic density (PSD) fractions (By similarity). Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin (By similarity). Membrane-associated (By similarity). Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TACC3, AURKA, SYP, etc.) including CPE-containing RNAs (By similarity). {ECO:0000250, ECO:0000269|PubMed:18923137}.
uniprot
proteins