TBC1D17
entrez
79735
canonical
uniprot
Q9HA65
canonical
ensembl
ENSG00000104946
resolver
ensp
ENSP00000221543
resolver
ensp
ENSP00000446323
resolver
ensp
ENSP00000656911
resolver
ensp
ENSP00000729296
resolver
genesymbol
TBC1D17
resolver
hgnc
HGNC:25699
resolver
uniprot
B4DT12
resolver
uniprot
B9A6L8
resolver
uniprot
F5H1W7
resolver
uniprot_entry
TBC17_HUMAN
resolver
uniprot_sec
B4DT12
resolver
uniprot_sec
B9A6L8
resolver
uniprot_sec
F5H1W7
resolver
amino_acid_sequence
MEGAGYRVVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQILFSKKDSSGGDSCASEEEPTFDPGYEPDWAVISTVRPQLCHSEPTRGAEPSCPQGSWAFSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQDSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQPQPEGAASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELPHNVQEILGLAPPAEPHSPSPTASPLPLSPTRAPPTPPPSTDTAPQPDSSLEILPEEEDEGADS
uniprot
proteins
function
FUNCTION: Probable RAB GTPase-activating protein that inhibits RAB8A/B function. Reduces Rab8 recruitment to tubules emanating from the endocytic recycling compartment (ERC) and inhibits Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TfR) (PubMed:22854040). Involved in regulation of autophagy. {ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:24752605}.
uniprot
proteins
mass_dalton
72670
uniprot
proteins
mutagenesis
MUTAGEN 381; /note="R->A: Strongly decreased inhibition of Rab8-mediated transferrin receptor (TfR) endocytic trafficking; enhanced Rab8 localization on ERC tubules and Rab8 interaction with TfR; impaired inhibitory effect on autophagy."; /evidence="ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:24752605
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19077034
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22854040
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24752605
uniprot
proteins
sequence_length
648
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:24752605}. Cytoplasm {ECO:0000269|PubMed:22854040}. Recycling endosome {ECO:0000269|PubMed:22854040}. Note=In the presence of optineurin/OPTN, may be recruited to recycling endosomes. {ECO:0000269|PubMed:22854040}.
uniprot
proteins