Entpd5
entrez
314312
canonical
uniprot
Q6P6S9
canonical
ensembl
ENSRNOG00000033206
resolver
ensp
ENSRNOP00000041026
resolver
ensp
ENSRNOP00000083944
resolver
enst
ENSRNOT00000041163
resolver
enst
ENSRNOT00000097901
resolver
genesymbol
Entpd5
resolver
uniprot
A0A8I5ZWS8
resolver
uniprot
F1LPB8
resolver
uniprot_entry
A0A8I5ZWS8_RAT
resolver
uniprot_entry
ENTP5_RAT
resolver
uniprot_entry
F1LPB8_RAT
resolver
amino_acid_sequence
MATSWASVFLLIIAYVGGTVFYREQQTWFEGVFLSSMCPVNVSAGTFYGIMFDAGSTGTRIHVYTFVQRTSGQLPFLEGEIFDSVKPGLSAFVDQPKQGAETVQELLEVAKDSIPRSHWKRTPVVLKATAGLRLLPEQKAQTLLLEVEEIFKNSPFLVPDDSVSIMDGSYEGILAWVTVNFLTGQLHGRGQETVGTLDLGGASTQITFLPQLEKTLEQTPKGYLASFEMFNSTFKLYTHSYLGFGLKAARLATLGALEAEGTDGHTFRSACLPRWLEAEWIFGGVKYQYGGNQEGEMGFEPCYAEVRRVVQGKLHQPEEIRGSSFYAFSYYYDRAAETHLIDYEKGGVLKVEDFERKAREVCDNLESFSSGSPFLCMDLSYITALLKDGFGFEDGTLLQLTKKVNNIETGWALGATFHLLQSLGITS
uniprot
proteins
ec_number
3.6.1.6
uniprot
proteins
function
FUNCTION: Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (By similarity). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity). {ECO:0000250|UniProtKB:O75356, ECO:0000250|UniProtKB:Q9WUZ9}.
uniprot
proteins
mass_dalton
47373
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q9WUZ9}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; high-mannose type. {ECO:0000250|UniProtKB:Q9WUZ9}.
uniprot
proteins
protein_family
GDA1/CD39 NTPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
427
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9WUZ9}. Secreted {ECO:0000250|UniProtKB:O75356}.
uniprot
proteins