PCGF3
entrez
10336
canonical
uniprot
Q3KNV8
canonical
ensembl
ENSG00000185619
resolver
ensp
ENSP00000354724
resolver
ensp
ENSP00000540421
resolver
ensp
ENSP00000540423
resolver
ensp
ENSP00000624733
resolver
ensp
ENSP00000624737
resolver
genesymbol
PCGF3
resolver
genesymbol_syn
RNF3
resolver
genesymbol_syn
RNF3A
resolver
hgnc
HGNC:10066
resolver
uniprot
B3KQ06
resolver
uniprot
B3KWT8
resolver
uniprot
B4DTN5
resolver
uniprot
D3DVN1
resolver
uniprot
O15262
resolver
uniprot_entry
B3KQ06_HUMAN
resolver
uniprot_entry
B3KWT8_HUMAN
resolver
uniprot_entry
B4DTN5_HUMAN
resolver
uniprot_entry
PCGF3_HUMAN
resolver
uniprot_sec
D3DVN1
resolver
uniprot_sec
O15262
resolver
amino_acid_sequence
MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGMEVPGDIKGETCSAKQHLDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKFVVVTRWRFKKAPLLLHYRPKMDLL
uniprot
proteins
function
FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity). {ECO:0000250|UniProtKB:Q8BTQ0, ECO:0000269|PubMed:26151332}.
uniprot
proteins
mass_dalton
28115
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21282530
uniprot
proteins
pubmed
26151332
uniprot
proteins
pubmed
27568929
uniprot
proteins
sequence_length
242
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21282530}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q8BTQ0}. Note=Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome. {ECO:0000250|UniProtKB:Q8BTQ0}.
uniprot
proteins