Kctd7
entrez
212919
canonical
uniprot
Q8BJK1
canonical
ensembl
ENSMUSG00000034110
resolver
ensp
ENSMUSP00000044568
resolver
enst
ENSMUST00000040616
resolver
genesymbol
Kctd7
resolver
uniprot
B2RSZ3
resolver
uniprot
Q3USA6
resolver
uniprot
Q80WW8
resolver
uniprot
Q8C0S7
resolver
uniprot_entry
KCTD7_MOUSE
resolver
uniprot_sec
B2RSZ3
resolver
uniprot_sec
Q3USA6
resolver
uniprot_sec
Q80WW8
resolver
uniprot_sec
Q8C0S7
resolver
amino_acid_sequence
MVVVTGREPDSRHSDGAMSSSEAEDDFLEPATPTATQAGHGLPLLPQEFPEVVPLNIGGAHFTTRLSTLRRYEDTMLAAMFSGRHYIPTDSEGRYFIDRDGTHFGDVLNFLRSGDLPPREHVRAVHKEAQYYAIGPLLEQLENMQPLKGEKVRQAFLGLMPYYKDHLERIVEIARLRAVQRKARFAKLKVCVFKEEMPITPYECPLLNSLRFERSESDGQLFEHHCEVDVSFGPWEAVADVYDLLHCLVTDLSAQGLTVDHQCIGVCDKHLVNHYYCKRPIYEFKITWW
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of multiple substrates, leading to either their proteasomal or lysosomal degradation, or modulating their activity through non-degradative ubiquitination (PubMed:37450587). Regulates voltage-gated potassium channels, thereby modulating hyperpolarizing potassium currents in neurons and inducing potassium-dependent membrane hyperpolarization. Also regulates the neuronal glutamine transporter SLC38A2/SAT2, influencing neurotransmitter precursor availability (By similarity). Regulates calpain activity via atypical, non-degradative ubiquitination by mediating ubiquitination of CAPN1 via 'Lys6'-, 'Lys27'-, 'Lys29'-, and 'Lys63'-linked chains, and CAPN2 via 'Lys6'-linked chains, thereby preventing calpain autolysis (By similarity). Promotes lysosomal enzyme trafficking and maintains lysosomal function by acting as an endogenous regulator of CLN5, enhancing its ubiquitination and proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:Q96MP8, ECO:0000269|PubMed:35972048, ECO:0000269|PubMed:37450587}.; FUNCTION: May be involved in the control of excitability of cortical neurons. {ECO:0000269|PubMed:21710140}.
uniprot
proteins
mass_dalton
33080
uniprot
proteins
mutagenesis
MUTAGEN 76; /note="M->A: Markedly impaired interaction with CUL3."; /evidence="ECO:0000269|PubMed:37450587"; MUTAGEN 84; /note="R->A: Markedly impaired interaction with CUL3."; /evidence="ECO:0000269|PubMed:37450587"; MUTAGEN 85; /note="H->A: Markedly impaired interaction with CUL3."; /evidence="ECO:0000269|PubMed:37450587"; MUTAGEN 131; /note="Y->A: Markedly impaired interaction with CUL3."; /evidence="ECO:0000269|PubMed:37450587
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21710140
uniprot
proteins
pubmed
22693283
uniprot
proteins
pubmed
22748208
uniprot
proteins
pubmed
35972048
uniprot
proteins
pubmed
37450587
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
uniprot
proteins