AQP3
entrez
360
canonical
uniprot
Q92482
canonical
ensembl
ENSG00000165272
resolver
ensp
ENSP00000297991
resolver
ensp
ENSP00000493516
resolver
ensp
ENSP00000494946
resolver
enst
ENST00000645858
resolver
genesymbol
AQP3
resolver
hgnc
HGNC:636
resolver
uniprot
A0A2R8Y2R4
resolver
uniprot
A8K843
resolver
uniprot
B2RE16
resolver
uniprot
B4E034
resolver
uniprot
D3DRL3
resolver
uniprot
O00108
resolver
uniprot
Q6FGT2
resolver
uniprot
Q6FGW6
resolver
uniprot_entry
A0A2R8Y2R4_HUMAN
resolver
uniprot_entry
AQP3_HUMAN
resolver
uniprot_entry
B4E034_HUMAN
resolver
uniprot_sec
A8K843
resolver
uniprot_sec
B2RE16
resolver
uniprot_sec
D3DRL3
resolver
uniprot_sec
O00108
resolver
uniprot_sec
Q6FGT2
resolver
uniprot_sec
Q6FGW6
resolver
activity_regulation
ACTIVITY REGULATION: Glycerol transport is regulated by pH, with the porin being permeable to glycerol at pH 7.4 but not at pH 5.5 (PubMed:30420639). Water permeability, however, is not influenced by pH (PubMed:30420639). {ECO:0000269|PubMed:30420639}.
uniprot
proteins
amino_acid_sequence
MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI
uniprot
proteins
function
FUNCTION: Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:12239222, PubMed:30420639). Could also be permeable to urea (By similarity). Also participates in cell permeability to H2O2 and H2O2-mediated signaling (PubMed:20724658). In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair (By similarity). In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance (By similarity). {ECO:0000250|UniProtKB:P47862, ECO:0000250|UniProtKB:Q8R2N1, ECO:0000269|PubMed:12239222, ECO:0000269|PubMed:20724658, ECO:0000269|PubMed:30420639}.
uniprot
proteins
mass_dalton
31544
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
11751877
uniprot
proteins
pubmed
12239222
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18495115
uniprot
proteins
pubmed
20724658
uniprot
proteins
pubmed
30420639
uniprot
proteins
pubmed
7558005
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12239222}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14520}. Basolateral cell membrane {ECO:0000250|UniProtKB:P47862}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14520}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..42; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 57..74; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 101..121; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 160..177; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 190..206; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 243..264; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O14520
uniprot
proteins