PIN4
entrez
5303
canonical
uniprot
Q9Y237
canonical
ensembl
ENSG00000102309
resolver
ensp
ENSP00000362773
resolver
ensp
ENSP00000409154
resolver
genesymbol
PIN4
resolver
hgnc
HGNC:8992
resolver
uniprot
A8E0G6
resolver
uniprot
B3KXM0
resolver
uniprot
F5H1P5
resolver
uniprot
Q0D2H3
resolver
uniprot
Q3MHV0
resolver
uniprot
Q52M21
resolver
uniprot
Q5HYW6
resolver
uniprot
Q6IRW4
resolver
uniprot_entry
PIN4_HUMAN
resolver
uniprot_sec
A8E0G6
resolver
uniprot_sec
B3KXM0
resolver
uniprot_sec
F5H1P5
resolver
uniprot_sec
Q0D2H3
resolver
uniprot_sec
Q3MHV0
resolver
uniprot_sec
Q52M21
resolver
uniprot_sec
Q5HYW6
resolver
uniprot_sec
Q6IRW4
resolver
amino_acid_sequence
MPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGGDLGWMTRGSMVGPFQEAAFALPVSGMDKPVFTDPPVKTKFGYHIIMVEGRK
uniprot
proteins
ec_number
5.2.1.8
uniprot
proteins
function
FUNCTION: Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. {ECO:0000269|PubMed:19369196}.; FUNCTION: Isoform 2 binds to double-stranded DNA. {ECO:0000269|PubMed:19369196}.
uniprot
proteins
mass_dalton
13810
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="S->A: Abolishes phosphorylation and strongly reduces nuclear localization."; /evidence="ECO:0000269|PubMed:12860119"; MUTAGEN 19; /note="S->E: Does not abolish nuclear localization and reduces DNA-binding ability."; /evidence="ECO:0000269|PubMed:12860119
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus. {ECO:0000269|PubMed:12860119, ECO:0000269|PubMed:19369196}.; PTM: Isoform 2 is sumoylated with SUMO2 and SUMO3. {ECO:0000269|PubMed:16522211}.
uniprot
proteins
protein_family
PIN4 subfamily
uniprot
proteins
protein_family
PpiC/parvulin rotamase family
uniprot
proteins
pubmed
10100858
uniprot
proteins
pubmed
10364457
uniprot
proteins
pubmed
10966801
uniprot
proteins
pubmed
11162102
uniprot
proteins
pubmed
12144781
uniprot
proteins
pubmed
12860119
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16522211
uniprot
proteins
pubmed
17875217
uniprot
proteins
pubmed
19369196
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
131
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion. Mitochondrion matrix. Note=Imported in a time- and membrane potential-dependent manner to the mitochondrial matrix, but without concomitant processing of the protein. Directed to mitochondria by a novel N-terminal domain that functions as a non-cleavable mitochondrial targeting peptide.
uniprot
proteins