Tfap2b
entrez
21419
canonical
uniprot
Q61313
canonical
ensembl
ENSMUSG00000025927
resolver
ensp
ENSMUSP00000027059
resolver
ensp
ENSMUSP00000064488
resolver
ensp
ENSMUSP00000140213
resolver
ensp
ENSMUSP00000236661
resolver
enst
ENSMUST00000027059
resolver
enst
ENSMUST00000064976
resolver
enst
ENSMUST00000187754
resolver
genesymbol
Tfap2b
resolver
genesymbol_syn
Tcfap2b
resolver
uniprot
A0A087WQI9
resolver
uniprot
E9Q5N4
resolver
uniprot
Q8CCV4
resolver
uniprot
Q8CE69
resolver
uniprot
Q8CEP1
resolver
uniprot_entry
A0A087WQI9_MOUSE
resolver
uniprot_entry
AP2B_MOUSE
resolver
uniprot_entry
E9Q5N4_MOUSE
resolver
uniprot_entry
Q8CCV4_MOUSE
resolver
uniprot_entry
Q8CE69_MOUSE
resolver
uniprot_sec
Q8CEP1
resolver
amino_acid_sequence
MHSPPRDQAAIMLWKLVENVKYEDIYEDRHDGVPSHSSRLSQLGSVSQGPYSSAPPLSHTPSSDFQPPYFPPPYQPLPYHQSQDPYSHVNDPYSLNPLHQPQQHPWGQRQRQEVGSEAGSLLPQPRAALPQLSGLDPRRDYHSVRRPDVLLHSAHHGLDAGMGDSLSLHGLGHPGMEDVQSVEDANNSGMNLLDQSVIKKVPVPPKSVTSLMMNKDGFLGGMSVNTGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETEFPAKAVSEYLNRQHTDPSDLHSRKNMLLATKQLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLITHGFGAPAICAALTALQNYLTEALKGMDKMFLNNTTNRHTSGEGPGSKTGDKEEKHRK
uniprot
proteins
function
FUNCTION: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. {ECO:0000250|UniProtKB:Q92481}.
uniprot
proteins
mass_dalton
50373
uniprot
proteins
post_translational_modification
PTM: Sumoylated (PubMed:25187989). Sumoylated on Lys-21; which inhibits transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q92481, ECO:0000269|PubMed:25187989}.
uniprot
proteins
protein_family
AP-2 family
uniprot
proteins
pubmed
12504852
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
25187989
uniprot
proteins
pubmed
7555706
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25187989}. Note=In the brain, localizes to the arcuate hypothalamic nucleus, the ventromedial hypothalamic nucleus and the accumbens nucleus of the ventral striatum. {ECO:0000269|PubMed:25187989}.
uniprot
proteins