PARVB
entrez
29780
canonical
uniprot
Q9HBI1
canonical
ensembl
ENSG00000188677
resolver
ensp
ENSP00000342492
resolver
ensp
ENSP00000384353
resolver
ensp
ENSP00000384515
resolver
ensp
ENSP00000482511
resolver
ensp
ENSP00000704819
resolver
enst
ENST00000619710
resolver
genesymbol
PARVB
resolver
hgnc
HGNC:14653
resolver
uniprot
A0A087WZB5
resolver
uniprot
B0QYM8
resolver
uniprot
B0QYN1
resolver
uniprot
B2R9X6
resolver
uniprot
Q5TGJ5
resolver
uniprot
Q86X93
resolver
uniprot
Q96PN1
resolver
uniprot
Q9NSP7
resolver
uniprot
Q9UGT3
resolver
uniprot
Q9Y368
resolver
uniprot
Q9Y3L6
resolver
uniprot
Q9Y3L7
resolver
uniprot_entry
A0A087WZB5_HUMAN
resolver
uniprot_entry
PARVB_HUMAN
resolver
uniprot_sec
B0QYM8
resolver
uniprot_sec
B0QYN1
resolver
uniprot_sec
B2R9X6
resolver
uniprot_sec
Q5TGJ5
resolver
uniprot_sec
Q86X93
resolver
uniprot_sec
Q96PN1
resolver
uniprot_sec
Q9NSP7
resolver
uniprot_sec
Q9UGT3
resolver
uniprot_sec
Q9Y368
resolver
uniprot_sec
Q9Y3L6
resolver
uniprot_sec
Q9Y3L7
resolver
amino_acid_sequence
MSSAPRSPTPRPRRMKKDESFLGKLGGTLARKRRAREVSDLQEEGKNAINSPMSPALVDVHPEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLVAILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEMMMGRFERDAFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFVPLHHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKYKNVE
uniprot
proteins
function
FUNCTION: Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}.
uniprot
proteins
mass_dalton
41714
uniprot
proteins
mutagenesis
MUTAGEN 256; /note="V->Q: Abolishes interaction with PXN."; /evidence="ECO:0000269|PubMed:22869380"; MUTAGEN 299; /note="F->D: Abolishes interaction with ILK. Abolishes location at focal adhesion sites."; /evidence="ECO:0000269|PubMed:22869380
uniprot
proteins
protein_family
Parvin family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11171322
uniprot
proteins
pubmed
11402068
uniprot
proteins
pubmed
11722847
uniprot
proteins
pubmed
12529303
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15005707
uniprot
proteins
pubmed
15159419
uniprot
proteins
pubmed
15284246
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15835269
uniprot
proteins
pubmed
18325335
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22869380
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.
uniprot
proteins