Pdp2
entrez
246311
canonical
uniprot
O88484
canonical
ensembl
ENSRNOG00000012343
resolver
ensembl
ENSRNOG00055009779
resolver
ensembl
ENSRNOG00060013354
resolver
ensembl
ENSRNOG00065011225
resolver
ensp
ENSRNOP00000016462
resolver
ensp
ENSRNOP00000112807
resolver
ensp
ENSRNOP00055013361
resolver
ensp
ENSRNOP00060017986
resolver
ensp
ENSRNOP00065013864
resolver
enst
ENSRNOT00000016462
resolver
enst
ENSRNOT00000156966
resolver
enst
ENSRNOT00055016566
resolver
enst
ENSRNOT00060022738
resolver
enst
ENSRNOT00065018180
resolver
genesymbol
Pdp2
resolver
uniprot
A0A0G2JSL7
resolver
uniprot
Q6IN27
resolver
uniprot_entry
PDP2_RAT
resolver
uniprot_sec
A0A0G2JSL7
resolver
uniprot_sec
Q6IN27
resolver
activity_regulation
ACTIVITY REGULATION: Mg(2+)-dependent protein phosphatase. Phosphatase activity is increased in the presence of spermine, a naturally produced polyamine. {ECO:0000269|PubMed:9651365}.
uniprot
proteins
amino_acid_sequence
MSSTASYRIFNFARNRIAVLRGGRRLYSRAATSRNQVKWRLFSPASLAVNDSSPHGGFALRKAYRHTSTEEEDFHLQLSPEQVSDLLRAGESSHKVLDFNSGVPNSVLRFESNQLAANSPVEDRQGVASCVQTRGTMFGIFDGHGGHACAQAVSERLFYYMAVSLMSHKTLEQMEEAMENMKPLLPILQWLKHPGDSIYKDITSVHLDHLRVYWQELLDLHMETGLSTEEALMYSFQRLDSDISLEIQAPLEDEVTKNLSLQVAFSGATACMAHVDGVHLHIANAGDCRAILGVQGDNGAWSCLPLTCDHNAWNEAELSRLKREHPESEDRTLIIDDRLLGVLLPCRAFGDVQLKWSKELQRNVLERGFDTEALNIYQFTPPHYHTPPYLTAKPEVTYHRLRPQDKFLVLASDGLWDMLDNEDVVRLVVGHLSKVGHQKPALDQRPANLGHMQSLLLQRKASGLHAADQNAATHLIRHAIGSNEYGEMEPERLAAMLTLPEDVARMYRDDITVMVVFFNSESIDTYFKEG
uniprot
proteins
ec_number
3.1.3.43
uniprot
proteins
function
FUNCTION: Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA (PubMed:14644048, PubMed:9651365). Acts as a crucial regulator of T cell metabolism and function, with a particular focus on T-helper Th17 (By similarity). {ECO:0000250|UniProtKB:Q504M2, ECO:0000269|PubMed:14644048, ECO:0000269|PubMed:9651365}.
uniprot
proteins
mass_dalton
59687
uniprot
proteins
protein_family
PP2C family
uniprot
proteins
pubmed
14644048
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9651365
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:9651365}.
uniprot
proteins