Q8R526
uniprot
Q8R526
canonical
amino_acid_sequence
MDVDEDQHAVAVLHHKIQANPELCVSDEQDSCPSDAPKGTARDPESQKPSSPAPWDKNVLNTGSEERLSFINGEPQAPPNWDEGTNSFSNPPPGISHTCNLSASWYHPESSSPLTQHPPRATLVTQPENVEHFAICCFPETDAQALPALGIRVHVASGTALCLLLDFGDNCGAQMRLCTLAGATTVTGYHQYRKEGVYELKAVVHDFHRAEELGPYYVDISHGNVSVFMNSSSIHDSEALSFADSLPQQRGTVVVHCFSSISSYNVSFISQTQVASGQAWCGVTVGYKMQSVSVYTNGTVFAANTNITFVAITEETIPLEFAWYFGENPPVMTTSRSIRRRLSVPQWYRVKVKATSRIGSVVSEPHLIRVQKRIMANRLVSTASALVNANVSFECRLNFGTDVAYLWNFGDDTIELGSSSSSHVYSREGEFTVEVLAFNNVSSTTLRKQLFIVREPCQPPPVKNMGPAKVQIWRSQPLRLGVTFEAAILCNISQGLSYTWSFVSAEMTTVTLPTAVNTRRQTIMLPSYTLECGNYTAIAKVQIKGSMVYSNYCVGVEVRARAPVSVISEGTHIFISTATSTFIILRGAQSYDPDNPGAALRYHWTCTAASSPRWPCFDNSTSYQVDTQAPAISFPAKWLSECCDQFLVTLTVSSRGQNSSQALMFLSTRPDLAFRFVHISWVNFRDISVNWNEEVSLRAVCEDCGDVPDLTYSWDLFLVNATEKSAVEVPFCSTVGLLGALALGTSLKSSKSDLPSNLRAPLTPHSPEPSPTPLGWTALSNLGSISAESTAGGHHVPASGAVAGSGEPMEEYSSLSSLAEEALMTNSSEGSWPSPSSSTDFDDFEAYYSDIQEAVLSLGRQPGTSTNFQEAGPSLSAEESASYGDNLLGPFLHTGRAKPTLMIDWPKALVSQAAFHGYTTSGIMGPAVTIKPFSLSSGKTYVLQASVASKHVLLGKAQLYLTVNQAPQDMSCQVRPHHGMEAYTIFSVFCMSGKPDFHYEFRYRIGNTSSHTLYRGQDTQHYFLLPAGDSSDNYKVIVSTEITDGHGSKVQPCTVAVTVLPRYHGNDCCDKELYNSTLESLSTLRLAGSYMETRNYITMITGILSRLYVESRNTSSCGQWSQIQDVLISSACKVPYTDQEGMMDSIHILRDLISFPNKLSLTSAMCIFKYTKMFLAQGQFSRRLLVDKKLRVEFVLLISGVWEAAKEDARDGDYLQEEGMKIISDMLLACLSDEHQIHVSTGQMEFQTLLHRSPQSSIQNLGFVQVHFPSDLASLHSTTQEATQSSCYISQLMFFMKSPYLGGQVPGQVGGVMIPRLYSCESRRPILRGQLETPVTMEFGEEDYLHKRNPAMFVLLRDEVNVHRFTGLSENSQESLQIHIKFSKPVTRPFPIILLVRFSEKATPSDFLVKRVYFWDEQTVQMYVPAAPWKGANVGYLSLLDADYDRKPPNKYLAGAVNYTVHFQWIQCVFWDKTEWRSEGPYPQPGSSPEKVNCSYHHLAPVSVLRRKLNATLEVSSISEFQSHPHNLLPGIFSAFLLVLYGILVSKSRYVDCHEKKNPGFIFLEEDTLPGYQLYAVVIDTGFRSPVRFTSKVFIVLCGENGCSETKELCCPEKPLFGRNSRHTFILSIPNQLGPLQKIRLWHDSSGSSPCWFISHVMVKELCSGQAWFFSAQCWLAVSKLGGHVLREFFCLSHGLGFWKLFYSKFTEYLEDFHIWLSLYSQPPSRSYLHTQRLAVSFCLLCVYSCLTALVTVRDHQQRPLDVGPTAITLEPFCMALLCTLLACPVAQLLSLLFRCSKEARGDMQASTQWPLRGVKTETPQGHDSSGRPDSRQPSPHPTSDLLPWNDQAWRIAASSSAVVCSPFPMEACSHKHHDLREKSHYSPPSSQAPGSGFEELGSQKSRVCLLWSSSVAWAISGSASLACGLGTGFLGYWFVPAQCMWWLYLLLLSLVCCAFITQPLMICLAALVFAWKRKHDSKFFTESLQDATKGLDLELEEHSRTRVPLSPISYSPDTAEEAERVLATRQRERHLRWAQTPSKAKLRVTGERLRRESIMQAALRDMTTHSIMLLLLLFIAYGRFCPGEISLNHAIRKAFTRKANHSLGDLSSTEDWWDWTLSTLLDELYPERTSARAWGAQPGALGGQCHLIGPPVVKLLKISAGTACTPPRPFSELVEDVLPMHSNDLDLENQNVSPGGPETCGVKKESYMHSLGKTRHEAHAALTALRASKWIDHSTRAMSVHFTLYNPPTQLFTSVILGTECLPSGGLVPSFLVESFRIFYSDSALKYLLMLSELLFLVLNVIHLCFQLWGMTTKGILSYWRKPRHWLELSMVGVAIAYYAASGHLTTLAVNITDQFHKGLYQRLVDIGLMVSWHQRARCLQGILLFLWMLKYVHLLSSLSTMTPFSAVTCFPLFRVLLVGALLLAAHYHSRWFLLFTGTLSHGTSAEAFPGLLLQFPGRSKKDSWHNCLKSDHGVMRCYYGTLFLLLATLGFRMLRATFLTVFQNRKSSHRKPLVTLKDIAVYTWHKVLTLLGLETTLEETEVATDHIYYLDEFSSLLDELLMKIDGLSDSLELSILENQWKRALESRAGDSPPVGSSEYQATGVSGPLAAESE
uniprot
proteins
function
FUNCTION: Component of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, without affecting cytoplasmic calcium concentration, and regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336289). The PKD1L1:PKD2L1 channel complex is mechanosensitive only at high pressures and is highly temperature sensitive (By similarity). Also involved in left/right axis specification downstream of nodal flow by forming a complex with PKD2 in cilia to facilitate flow detection in left/right patterning (PubMed:21307093). May function as a G protein-coupled receptor (By similarity). {ECO:0000250|UniProtKB:Q8TDX9, ECO:0000269|PubMed:21307093, ECO:0000269|PubMed:24336289}.
uniprot
proteins
mass_dalton
290844
uniprot
proteins
mutagenesis
MUTAGEN 411; /note="D->G: In rks; mice exhibit gross left-right abnormalities. Embryos do not show defects in kidney development. The nodes appear normal."; /evidence="ECO:0000269|PubMed:21307093
uniprot
proteins
protein_family
Polycystin family
uniprot
proteins
pubmed
11863367
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20080492
uniprot
proteins
pubmed
21307093
uniprot
proteins
pubmed
24336289
uniprot
proteins
pubmed
38247840
uniprot
proteins
sequence_length
2615
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000269|PubMed:21307093}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 1525..1545; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1733..1753; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1773..1793; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1906..1926; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1951..1971; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2058..2078; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2289..2309; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2333..2353; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2380..2400; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2406..2426; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2484..2504; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins