Gabra1
entrez
29705
canonical
uniprot
P62813
canonical
ensembl
ENSRNOG00000003512
resolver
ensembl
ENSRNOG00055005301
resolver
ensembl
ENSRNOG00060021305
resolver
ensembl
ENSRNOG00065001344
resolver
ensp
ENSRNOP00000004725
resolver
ensp
ENSRNOP00000087043
resolver
ensp
ENSRNOP00055006470
resolver
ensp
ENSRNOP00060030419
resolver
ensp
ENSRNOP00065001239
resolver
enst
ENSRNOT00000004725
resolver
enst
ENSRNOT00055008521
resolver
enst
ENSRNOT00060036907
resolver
enst
ENSRNOT00065001781
resolver
genesymbol
Gabra1
resolver
genesymbol_syn
Gabra-1
resolver
uniprot
P18504
resolver
uniprot
Q53YK4
resolver
uniprot_entry
GBRA1_RAT
resolver
uniprot_sec
P18504
resolver
uniprot_sec
Q53YK4
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by benzodiazepines and pentobarbital (PubMed:1977069). Allosterically activated by the neuroanesthetic alphaxalone (By similarity). Inhibited by the antagonist bicuculline (PubMed:1376242, PubMed:1977069). Potentiated by pentobarbital, loreclezole, and lanthanum and inhibited by zinc and furosemide (PubMed:9882711). Potentiated by histamine (PubMed:18281286). {ECO:0000250|UniProtKB:P14867, ECO:0000269|PubMed:1376242, ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:1977069, ECO:0000269|PubMed:9882711}.
uniprot
proteins
amino_acid_sequence
MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
uniprot
proteins
function
FUNCTION: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:1376242, PubMed:1977069, PubMed:2540033, PubMed:9882711). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:30044221). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:18281286, PubMed:1977069, PubMed:9882711). Alpha-1/GABRA1-containing GABAARs are largely synaptic (PubMed:9464994). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed:18281286, PubMed:1977069). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (PubMed:18281286, PubMed:1977069). GABAARs containing alpha, beta and epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (PubMed:9882711). Alpha-1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Together with rho subunits, may also control neuronal and glial GABAergic transmission in the cerebellum (By similarity). {ECO:0000250|UniProtKB:P14867, ECO:0000250|UniProtKB:P62812, ECO:0000269|PubMed:1376242, ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:1977069, ECO:0000269|PubMed:2540033, ECO:0000269|PubMed:30044221, ECO:0000269|PubMed:9464994, ECO:0000269|PubMed:9882711}.
uniprot
proteins
mass_dalton
51754
uniprot
proteins
mutagenesis
MUTAGEN 91; /note="F->L: Strongly decreases the affinity for GABA-dependent channel gating."; /evidence="ECO:0000269|PubMed:1376242
uniprot
proteins
protein_family
GABRA1 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
11528422
uniprot
proteins
pubmed
1376242
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17003036
uniprot
proteins
pubmed
18281286
uniprot
proteins
pubmed
1966765
uniprot
proteins
pubmed
1977069
uniprot
proteins
pubmed
25172774
uniprot
proteins
pubmed
2540033
uniprot
proteins
pubmed
2561977
uniprot
proteins
pubmed
28279354
uniprot
proteins
pubmed
30044221
uniprot
proteins
pubmed
9464994
uniprot
proteins
pubmed
9882711
uniprot
proteins
sequence_length
455
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:9464994}; Multi-pass membrane protein {ECO:0000269|PubMed:30044221}. Cell membrane {ECO:0000269|PubMed:1376242, ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:2540033, ECO:0000269|PubMed:9464994}; Multi-pass membrane protein {ECO:0000269|PubMed:30044221}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:25172774}. Note=The alpha-1 subunits (alpha-1-beta-2/3-gamma-2 receptors) are present in Golgi synapses and on the extrasynaptic membranes (PubMed:9464994). Mainly located in GABAergic synapses on granule cells (PubMed:9464994). {ECO:0000269|PubMed:9464994}.
uniprot
proteins
transmembrane_region
TRANSMEM 253..273; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P14867"; TRANSMEM 279..300; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P14867"; TRANSMEM 311..332; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P14867"; TRANSMEM 421..440; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P14867
uniprot
proteins