CENPX
entrez
201254
canonical
uniprot
A8MT69
canonical
ensembl
ENSG00000169689
resolver
ensp
ENSP00000302951
resolver
ensp
ENSP00000376168
resolver
ensp
ENSP00000462015
resolver
ensp
ENSP00000464357
resolver
ensp
ENSP00000654859
resolver
enst
ENST00000584347
resolver
genesymbol
CENPX
resolver
genesymbol_syn
FAAP10
resolver
genesymbol_syn
MHF2
resolver
genesymbol_syn
STRA13
resolver
hgnc
HGNC:11422
resolver
uniprot
J3QRS1
resolver
uniprot
O00281
resolver
uniprot
O00282
resolver
uniprot
Q96DD4
resolver
uniprot
Q96F51
resolver
uniprot_entry
CENPX_HUMAN
resolver
uniprot_entry
J3QRS1_HUMAN
resolver
uniprot_sec
O00281
resolver
uniprot_sec
O00282
resolver
uniprot_sec
Q96DD4
resolver
uniprot_sec
Q96F51
resolver
amino_acid_sequence
MEGAGAGSGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVVEAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF
uniprot
proteins
function
FUNCTION: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:20347429). DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347429). {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429}.
uniprot
proteins
mass_dalton
8959
uniprot
proteins
protein_family
CENP-X/MHF2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19620631
uniprot
proteins
pubmed
20347428
uniprot
proteins
pubmed
20347429
uniprot
proteins
pubmed
22304917
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24522885
uniprot
proteins
sequence_length
81
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:24522885}. Chromosome, centromere {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:24522885}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:24522885}. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPX being less stably bound at the kinetochore than CENPS. {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:24522885}.
uniprot
proteins