TNLG1B
entrez
9966
canonical
uniprot
O95150
canonical
ensembl
ENSG00000181634
resolver
ensp
ENSP00000363157
resolver
genesymbol
TNFSF15
resolver
genesymbol
TNLG1B
resolver
genesymbol_syn
TL1
resolver
genesymbol_syn
TL1A
resolver
genesymbol_syn
VEGI
resolver
hgnc
HGNC:11931
resolver
uniprot
A0A0U5JA19
resolver
uniprot
Q3SX69
resolver
uniprot
Q5VJK8
resolver
uniprot
Q5VWH1
resolver
uniprot
Q8NFE9
resolver
uniprot_entry
A0A0U5JA19_HUMAN
resolver
uniprot_entry
TNF15_HUMAN
resolver
uniprot_sec
Q3SX69
resolver
uniprot_sec
Q5VJK8
resolver
uniprot_sec
Q5VWH1
resolver
uniprot_sec
Q8NFE9
resolver
amino_acid_sequence
MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL
uniprot
proteins
function
FUNCTION: Cytokine that signals through TNFRSF25 receptor (PubMed:11911831). Functions as a T-cell costimulator, that increases IL-2 responsiveness and secretion of proinflammatory cytokines which enhances T-cell activation, proliferation and the survival of activated T-cells (PubMed:10597252, PubMed:11911831). Inhibits vascular endothelial growth and angiogenesis (in vitro) (PubMed:11923219, PubMed:9872942). Binds to the decoy receptor TNFRSF6B, blocking the activation normally triggered by TNFSF15 and leading to decreased T-cell activation and reduced inflammation (PubMed:21300286). {ECO:0000269|PubMed:10597252, ECO:0000269|PubMed:11911831, ECO:0000269|PubMed:11923219, ECO:0000269|PubMed:21300286, ECO:0000269|PubMed:9872942}.
uniprot
proteins
mass_dalton
28087
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
10597252
uniprot
proteins
pubmed
11911831
uniprot
proteins
pubmed
11923219
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17935696
uniprot
proteins
pubmed
21300286
uniprot
proteins
pubmed
9434163
uniprot
proteins
pubmed
9872942
uniprot
proteins
sequence_length
251
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}; Single-pass type II membrane protein {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 15, secreted form]: Secreted {ECO:0000269|PubMed:11911831}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins