Rab43
entrez
69834
canonical
uniprot
Q8CG50
canonical
ensembl
ENSMUSG00000030055
resolver
ensp
ENSMUSP00000032134
resolver
ensp
ENSMUSP00000077716
resolver
enst
ENSMUST00000032134
resolver
enst
ENSMUST00000078647
resolver
genesymbol
Rab43
resolver
genesymbol_syn
Rab41
resolver
uniprot
F8WJA9
resolver
uniprot
Q0PD10
resolver
uniprot
Q91Z34
resolver
uniprot_entry
F8WJA9_MOUSE
resolver
uniprot_entry
Q0PD10_MOUSE
resolver
uniprot_entry
Q91Z34_MOUSE
resolver
uniprot_entry
RAB43_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) including USP6NL, which increase the GTP hydrolysis activity (By similarity). Inhibited by GDP dissociation inhibitors (GDIs) (By similarity). {ECO:0000250|UniProtKB:P62820, ECO:0000250|UniProtKB:Q86YS6}.
uniprot
proteins
amino_acid_sequence
MAGPGPGDQDEHYDFLFKLVLVGDASVGKTCVVQRFKTGAFSARQGSTIGVDFTMKTLEIQGKRVKLQIWDTAGQERFRTITQSYYRSANGAILAYDISKRSTFLSVPHWIEDVRKYAGSNIVQLLIGNKSDLADFREVPLAEAQSLAEHYDILCAIETSAKDSSNVEEAFTRVATELIMRHGGPMFSEKNTDHIQLDSKDIAESWGCGC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Required for the structural integrity of the Golgi complex. Also controls the anterograde ER-to-Golgi transport of nascent G protein-coupled receptors (including ADRA2A, ADRA2B, ADRA2C, ADRA1B, ADRB2 and AGTR1) and regulates the ER sorting of GPCR members by virtue of its ability to interact directly. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. {ECO:0000250|UniProtKB:Q86YS6}.
uniprot
proteins
mass_dalton
23263
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29125462
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q86YS6}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000250|UniProtKB:Q86YS6}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q86YS6}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000250|UniProtKB:Q86YS6}.
uniprot
proteins