Slc7a10
entrez
53896
canonical
uniprot
P63115
canonical
ensembl
ENSMUSG00000030495
resolver
ensp
ENSMUSP00000001854
resolver
ensp
ENSMUSP00000263741
resolver
ensp
ENSMUSP00000263747
resolver
ensp
ENSMUSP00000263775
resolver
enst
ENSMUST00000001854
resolver
genesymbol
Slc7a10
resolver
genesymbol_syn
Asc1
resolver
uniprot
Q9CW25
resolver
uniprot
Q9JMH8
resolver
uniprot_entry
AAA1_MOUSE
resolver
uniprot_sec
Q9CW25
resolver
uniprot_sec
Q9JMH8
resolver
amino_acid_sequence
MRRDSDMASHIQQPGGHGNPGPAPSPSPGPGPGPGASERVALKKEIGLVSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAELGVAIPKSGGDYAYVTEIFGGLAGFLLLWSAVLIMYPTSLAVISMTFSNYVLQPVFPNCIPPATASRVLSMACLMLLTWVNSSSVRWATRIQVIFTGGKLLALSLIITVGFVQIFQGHFEELRPTNAFAFWMTPSVGHLALAFLQGSFAFSGWNFLNYVTEELVDPRKNLPRAIFISIPLVTFVYTFTNVAYFTAMSPQELLSSNAVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTSSRLCFSGAREGHLPSFLAMIHVRRCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLVLRWRRPALHRPIKVNLLVPVVYLVFWAFLLVFSFISEPMVCGVGIIIILTGVPIFFLGVFWRSKPKCVHRFTESMTRWGQELCFVVYPQGSLEEEENGPMGQPSPLPITDKPLKTQ
uniprot
proteins
function
FUNCTION: Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion (By similarity) (PubMed:10734121). Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons (PubMed:25755256, PubMed:27759100). At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission (By similarity). May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment (PubMed:33707431). {ECO:0000250|UniProtKB:P63116, ECO:0000269|PubMed:10734121, ECO:0000269|PubMed:25755256, ECO:0000269|PubMed:27759100, ECO:0000269|PubMed:33707431}.
uniprot
proteins
mass_dalton
57549
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
pubmed
10734121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
25755256
uniprot
proteins
pubmed
27759100
uniprot
proteins
pubmed
33707431
uniprot
proteins
pubmed
34749773
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:33707431, ECO:0000269|PubMed:34749773}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with OLIG2 in astrocytic processes (PubMed:34749773). Localizes to the plasma membrane in mature adipocytes and to intracellular structures in preadipocytes (PubMed:33707431). {ECO:0000269|PubMed:33707431, ECO:0000269|PubMed:34749773}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..66; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 78..98; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 119..139; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 274..294; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 316..336; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 368..388; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 394..414; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 430..450; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 454..474; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins