Kcns1
entrez
117023
canonical
uniprot
O88758
canonical
ensembl
ENSRNOG00000013681
resolver
ensembl
ENSRNOG00055004048
resolver
ensembl
ENSRNOG00060001185
resolver
ensp
ENSRNOP00000018364
resolver
ensp
ENSRNOP00055004958
resolver
ensp
ENSRNOP00060000894
resolver
enst
ENSRNOT00000018364
resolver
enst
ENSRNOT00055006467
resolver
enst
ENSRNOT00060001679
resolver
genesymbol
Kcns1
resolver
uniprot_entry
KCNS1_RAT
resolver
amino_acid_sequence
MVSEFPGPGSRVPWRPRDEALRVNVGGVRRLLSARALARFPGTRLGRLQAAVSEEQARRLCDDYDAAAREFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALATCCRARYLERRVTRPRAWDEDSDAPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSAEDVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALGDRRGASGEELGDLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEEKNVGFDTIPACWWWGTVSMTTVGYGDVVPETVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRSSGQREFEDLLSSVDGVSDVSLETSRETSQEGRSTDLETQAPSEPAKSHSY
uniprot
proteins
function
FUNCTION: Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2 (By similarity). Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process (By similarity). {ECO:0000250|UniProtKB:O35173, ECO:0000250|UniProtKB:Q96KK3}.
uniprot
proteins
mass_dalton
54915
uniprot
proteins
protein_family
Kv9.1/KCNS1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
protein_family
S (TC 1.A.1.2) subfamily
uniprot
proteins
pubmed
9704029
uniprot
proteins
sequence_length
497
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96KK3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96KK3}. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2. {ECO:0000250|UniProtKB:Q96KK3}.
uniprot
proteins
transmembrane_region
TRANSMEM 187..208; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 240..262; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 274..291; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 310..330; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 346..367; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 407..435; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:P63142
uniprot
proteins