Tmub1
entrez
64295
canonical
uniprot
Q9JMG3
canonical
ensembl
ENSMUSG00000028958
resolver
ensp
ENSMUSP00000030799
resolver
genesymbol
Tmub1
resolver
genesymbol_syn
Hops
resolver
uniprot
Q53AQ3
resolver
uniprot_entry
TMUB1_MOUSE
resolver
uniprot_sec
Q53AQ3
resolver
amino_acid_sequence
MALIEGVGDEVTVLFAVLACLLVLALAWVSTHTTESTDPQPQPPGTTTPAQPSEAMSASDSIREEAPGAESPSLRHRGPSAQPEPDTGVTASTPPDSPQEPLLLRLKFLNDSEQVARAWPQDTIGSLKRTQFPGQEQQVRLIYQGQLLGDDTQTLGSLHLPPNCVLHCHVSTRVGPPHPPCPPGSEPGPSGLEIGSLLLPLLLLLLLLLWYCQIQYRPFFPLTATLGLAGFTLLLSLLAFAMYRP
uniprot
proteins
function
FUNCTION: Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (By similarity). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as a negative regulator of hepatocyte growth during regeneration (By similarity). {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000250|UniProtKB:Q9BVT8, ECO:0000269|PubMed:16014383, ECO:0000269|PubMed:18418082, ECO:0000269|PubMed:22890319}.; FUNCTION: [iHOPS]: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (PubMed:16014383). May be involved in centrosome assembly (PubMed:18418082). Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (PubMed:22890319). {ECO:0000269|PubMed:18418082, ECO:0000269|PubMed:22890319}.
uniprot
proteins
mass_dalton
26316
uniprot
proteins
post_translational_modification
PTM: [iHOPS]: Isoform 1 (lHOPS) is processed by regulated intramembrane proteolysis (RIP) in the N-terminus to release iHOPS from membranes. {ECO:0000269|PubMed:24240191}.; PTM: Isoform 2 seems to undergo a selective cleavage in the C-terminal region to release an additional cytoplasmic form. {ECO:0000269|PubMed:24240191}.
uniprot
proteins
pubmed
10679242
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16014383
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18418082
uniprot
proteins
pubmed
18665261
uniprot
proteins
pubmed
20582322
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22890319
uniprot
proteins
pubmed
24240191
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:18665261}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000269|PubMed:18665261}. Recycling endosome {ECO:0000250|UniProtKB:Q53AQ4}. Cytoplasm {ECO:0000269|PubMed:16014383, ECO:0000269|PubMed:20582322}. Nucleus {ECO:0000269|PubMed:16014383}. Nucleus, nucleolus {ECO:0000269|PubMed:22890319}.; SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000305|PubMed:24240191}.; SUBCELLULAR LOCATION: [Isoform 2]: Membrane {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000305|PubMed:24240191}.; SUBCELLULAR LOCATION: [iHOPS]: Cytoplasm {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000305|PubMed:24240191}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000305|PubMed:24240191}. Nucleus, nucleolus {ECO:0000305|PubMed:24240191}. Nucleus {ECO:0000305|PubMed:24240191}. Note=iHOPS is proposed to be the shuttling form across different cellular compartments (PubMed:24240191). XPO1-dependent exported from the nucleus in dividing cells. Predominantly nuclear during growth arrest (PubMed:16014383). {ECO:0000269|PubMed:16014383, ECO:0000305|PubMed:24240191}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 194..214; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins