Nuf2
entrez
66977
canonical
uniprot
Q99P69
canonical
ensembl
ENSMUSG00000026683
resolver
ensp
ENSMUSP00000028000
resolver
ensp
ENSMUSP00000106999
resolver
genesymbol
Nuf2
resolver
genesymbol_syn
Cdca1
resolver
genesymbol_syn
Nuf2r
resolver
uniprot
Q8BTK7
resolver
uniprot
Q8VE05
resolver
uniprot
Q9CST5
resolver
uniprot_entry
NUF2_MOUSE
resolver
uniprot_sec
Q8BTK7
resolver
uniprot_sec
Q8VE05
resolver
uniprot_sec
Q9CST5
resolver
amino_acid_sequence
METLSFPRYNVAELVVHIRNKLLTGADGKNLSKSDFLPNPKSDVLYMIYMKALQLVYGVRLEHFYMMPMNIEVTYPHLMEGFLPVRSLFFYMDSFMPICRVNDFEIVDILNPRTNRTSRFLSGIINFIHFRETCLEKCEEFLLQNKSSMVRMQQLSNVHQEALMKLEKLNTVPAEEREEFKQFMDDIQELQHLLNEEFRQKTTLLQEEYAKMKSDISEKTKHLNEQKLSLVSLKEVEDNLKSKIVDSPEKLKNYKDKMKGTVQKLRSAREKVMEQYDIYRDSVDCLPSCQLEVQLYQKKSQDLADNREKLSSLLKESLNLEDQIESDSSELKKLKTEENSLIRMTTVKKEKLATARFKINKKQEDVKHYKQAMIEDCNKVQEKRDAVCEQVTTVNQEIHKIKSAIQQLRDTKKREILKSQEIFVNLKSALEKYHEGIEKVAEERSAKLEEKTAELKKRMVRMV
uniprot
proteins
function
FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. {ECO:0000250|UniProtKB:Q9BZD4}.
uniprot
proteins
mass_dalton
54594
uniprot
proteins
post_translational_modification
PTM: Can be phosphorylated by AURKA and AURKB. {ECO:0000250}.
uniprot
proteins
protein_family
NUF2 family
uniprot
proteins
pubmed
11266451
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore (By similarity). {ECO:0000250}.
uniprot
proteins