C5ar2
entrez
319430
canonical
uniprot
Q8BW93
canonical
ensembl
ENSMUSG00000074361
resolver
ensp
ENSMUSP00000096389
resolver
ensp
ENSMUSP00000133056
resolver
ensp
ENSMUSP00000158951
resolver
ensp
ENSMUSP00000159074
resolver
ensp
ENSMUSP00000320306
resolver
enst
ENSMUST00000098792
resolver
enst
ENSMUST00000171425
resolver
enst
ENSMUST00000238893
resolver
enst
ENSMUST00000238927
resolver
genesymbol
C5ar2
resolver
genesymbol_syn
C5l2
resolver
genesymbol_syn
Gpr77
resolver
uniprot
B2RQI1
resolver
uniprot
E9PVQ2
resolver
uniprot
E9QQ21
resolver
uniprot
Q3TVM8
resolver
uniprot_entry
C5AR2_MOUSE
resolver
uniprot_entry
E9PVQ2_MOUSE
resolver
uniprot_entry
E9QQ21_MOUSE
resolver
uniprot_sec
B2RQI1
resolver
uniprot_sec
Q3TVM8
resolver
amino_acid_sequence
MMNHTTSEYYDYEYDHEHYSDLPDVPVDCPAGTCFTSDVYLIVLLVLYAAVFLVGVPGNTLVAWVTWKESRHRLGASWFLHLTMADLLCCVSLPFLAVPIAQKGHWPYGAAGCWLLSSITILSMYASVLLLTGLSGDLFLLAFRPSWKGADHRTFGVRVVQASSWMLGLLLTVPSAVYRRLLQEHYPPRLVCGIDYGGSVSAEVAITTVRFLFGFLGPLVFMAGCHGILQRQMARRHWPLGTAVVVGFFICWTPYHVLRVIIAAAPPHSLLLARVLEAEPLFNGLALAHSALNPIMFLYFGRKQLCKSLQAACHWALRDPQDEESAVTKVSISTSHEMVSEMPV
uniprot
proteins
function
FUNCTION: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. Also acts as a receptor for dearginated forms of C3a, C4a and C5a anaphylatoxin peptides (ASP/C3adesArg, C4adesArg and C5adesArg, respectively). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase. {ECO:0000250|UniProtKB:Q9P296}.
uniprot
proteins
mass_dalton
38199
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15833747
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
sequence_length
344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9P296}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9P296}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..67; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 79..101; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 121..143; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 156..178; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 209..231; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 244..266; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 281..300; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins