GDPD3
entrez
79153
canonical
uniprot
Q7L5L3
canonical
ensembl
ENSG00000102886
resolver
ensp
ENSP00000384363
resolver
genesymbol
GDPD3
resolver
genesymbol_syn
GDE7
resolver
hgnc
HGNC:28638
resolver
uniprot
Q9H652
resolver
uniprot_entry
GDPD3_HUMAN
resolver
uniprot_sec
Q9H652
resolver
activity_regulation
ACTIVITY REGULATION: Lysophospholipase D activity is stimulated by calcium. Loss of lysophospholipase D activity in presence of EDTA. {ECO:0000269|PubMed:27637550}.
uniprot
proteins
amino_acid_sequence
MSLLLYYALPALGSYAMLSIFFLRRPHLLHTPRAPTFRIRLGAHRGGSGELLENTMEAMENSMAQRSDLLELDCQLTRDRVVVVSHDENLCRQSGLNRDVGSLDFEDLPLYKEKLEVYFSPGHFAHGSDRRMVRLEDLFQRFPRTPMSVEIKGKNEELIREIAGLVRRYDRNEITIWASEKSSVMKKCKAANPEMPLSFTISRGFWVLLSYYLGLLPFIPIPEKFFFCFLPNIINRTYFPFSCSCLNQLLAVVSKWLIMRKSLIRHLEERGVQVVFWCLNEESDFEAAFSVGATGVITDYPTALRHYLDNHGPAARTS
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
function
FUNCTION: Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:27637550). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso-PC) and N-acylethanolamine lysophospholipids (PubMed:27637550). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine. {ECO:0000250|UniProtKB:Q99LY2, ECO:0000269|PubMed:27637550}.
uniprot
proteins
mass_dalton
36596
uniprot
proteins
protein_family
Glycerophosphoryl diester phosphodiesterase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
27637550
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q99LY2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q99LY2}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q99LY2}. Endoplasmic reticulum {ECO:0000269|PubMed:27637550}. Note=Partially co-localized with CANX. {ECO:0000250|UniProtKB:Q99LY2}.
uniprot
proteins
transmembrane_region
TRANSMEM 3..23; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 199..221; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins