Nup98
entrez
81738
canonical
uniprot
P49793
canonical
ensembl
ENSRNOG00000020347
resolver
ensembl
ENSRNOG00065022678
resolver
ensp
ENSRNOP00000027575
resolver
genesymbol
Nup98
resolver
uniprot
D3ZMW4
resolver
uniprot_entry
NUP98_RAT
resolver
uniprot_sec
D3ZMW4
resolver
amino_acid_sequence
MFNKSFGTPFGGGTGGFGTTSTFGQNTGFGTTSGGAFGTSAFGSSNNTGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGFGTSTGTSNSLFGTANTGTSLFSSQNNAFAQNKPTGFGNFGTSTSSGGLFGTTNTTSNPFGNTSGSLFGPSSFTAAPTGTTIKFNPPTGTDTMVKAGVSTNISTKHQCITAMKEYESKSLEELRLEDYQANRKGPQNQVGAGTTTGLFGSSPATSSATGLFSSSTTNSAFSYGQNKTAFGTSTTGFGTNPGGLFGQQNQQTTSLFSKPFGQATTTPNTGFSFGNTSTLGQPSTNTMGLFGVTQASQPGGLFGTATNTSTGTAFGTGTGLFGQPNTGFGAVGSTLFGNNKLTTFGTSTTSAPSFGTTSGGLFGNKPTLTLGTNTNTSNFGFGTNNSGSSIFGSKPAAGTLGTGLGTGFGTALGAGQASLFGNNQPKIGGPLGTGAFGAPGFNTSTAILGFGAPQAPVALTDPNASAAQQAVLQQHLNSLTYSPFGDSPLFRNPMSDPKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVNHDSEDLASPSEYPENGERFSFLSKPVDENHQQDGDDDSLVSRFYTNPIAKPIPQTPESAGNKNNSSSNVEDTFIALNMRAALRNGLEGSSEETSFHDESLQDDRDEIENSAFQIHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPPKTTSKKLKTAPLPPAGQATTFQMTLNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVPDSVLEESVPEDQEPVSASTQIASSLGINPHVLQIMKASLLVDEEDVDAMEQRFGHFPSRGDTAQEICSPRLPISASHSSKSRSIVGGLLQSKFASGTFLSPSASVQECRTPRTSSLMNVPSTSPWSVPLPLATVFTVPSPAPEVPLKTVGIRRQPGLVPLEKSITYGKGKLLMDMALFMGRSFRVGWGPNWTLANSGEQLHGSHELENHQVAESMEYGFLPNPVAVKSLSESPFKVHLEKLGLRQRKLDEDLQLYQTPLELKLKHSTVHVDELCPLIVPNPGVSVIHGYADWVKKSPRDLLELPIVKHWSLTWTLCEALWGHLKELDSQLDEPSEYIQTLERRRAFSRWLSHTAAPQIEEEVSLTRRDSPIEAVFSYLTGSRISEACCLAQQSGDHRLALLLSQLVGSQSVRELLTMQLADWHQLQADSFIHDERLRIFALLAGKPVWQLSEQKQINVCSQLDWKRTLAIHLWYLLPPTASISRALSMYEEAFQNTCEGDKYACPPLPSYLEGSGCVVEEEKDPQRPLQDVCFHLLKLYSDRHYGLNQLLEPRSITADPLDYRLSWHLWEVLRALNYTHLSEQCEGVLQASYAGQLESEGLWEWAIFVFLHIDNSGMREKAVRELLTRHCQLSETPESWAKETFLTQKLCVPAEWIHEAKAVRAHMESNKHLEALYLFKAGHWNRCHKLVVRHLASDAIINENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLDYIRVIEMLHRIQQVDCSGYELEHLHTKVTSLCNRIEQIPCYNAKDRLAQSDMAKRVANLLRVVLSLQHTPDATSNSTPDPQRVPLRLLAPHIGRLPMPEDYALEELRGLTQSYLRELTVGSQ
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. {ECO:0000250|UniProtKB:P52948}.; FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body). {ECO:0000250|UniProtKB:P52948}.
uniprot
proteins
mass_dalton
197283
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.; PTM: Isoform 1 is autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively. Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96. {ECO:0000250|UniProtKB:P52948}.
uniprot
proteins
protein_family
Nucleoporin GLFG family
uniprot
proteins
pubmed
10087256
uniprot
proteins
pubmed
11839768
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7736573
uniprot
proteins
sequence_length
1816
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:10087256, ECO:0000269|PubMed:11839768}; Peripheral membrane protein {ECO:0000269|PubMed:10087256}; Nucleoplasmic side {ECO:0000269|PubMed:10087256}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:10087256}. Nucleus, nucleoplasm {ECO:0000269|PubMed:10087256}. Note=Localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket (PubMed:10087256). Dissociates from the disassembled NPC structure early during prophase of mitosis (By similarity). Colocalizes with NUP153 to the nuclear basket of NPC (By similarity). Colocalizes with TPR to the nuclear basket of NPC (PubMed:10087256, PubMed:11839768). Colocalized with DHX9 in diffuse and discrete intranuclear foci (GLFG-body) (By similarity). Remains localized to the nuclear membrane after poliovirus (PV) infection (By similarity). {ECO:0000250|UniProtKB:P52948, ECO:0000269|PubMed:10087256, ECO:0000269|PubMed:11839768}.
uniprot
proteins