RALGDS
entrez
5900
canonical
uniprot
Q12967
canonical
ensembl
ENSG00000160271
resolver
ensp
ENSP00000361117
resolver
ensp
ENSP00000361120
resolver
ensp
ENSP00000361132
resolver
ensp
ENSP00000376864
resolver
ensp
ENSP00000376867
resolver
genesymbol
RALGDS
resolver
genesymbol_syn
KIAA1308
resolver
genesymbol_syn
RGF
resolver
hgnc
HGNC:9842
resolver
uniprot
B7Z753
resolver
uniprot
E7ER93
resolver
uniprot
E7ERZ0
resolver
uniprot
Q5T7V4
resolver
uniprot
Q6KH11
resolver
uniprot
Q6PCE1
resolver
uniprot
Q6ZSD5
resolver
uniprot
Q8N4Y1
resolver
uniprot
Q9HAX7
resolver
uniprot
Q9HAY1
resolver
uniprot
Q9HCT1
resolver
uniprot
Q9P2N8
resolver
uniprot_entry
GNDS_HUMAN
resolver
uniprot_entry
Q8N4Y1_HUMAN
resolver
uniprot_sec
B7Z753
resolver
uniprot_sec
E7ER93
resolver
uniprot_sec
E7ERZ0
resolver
uniprot_sec
Q5T7V4
resolver
uniprot_sec
Q6KH11
resolver
uniprot_sec
Q6PCE1
resolver
uniprot_sec
Q6ZSD5
resolver
uniprot_sec
Q9HAX7
resolver
uniprot_sec
Q9HAY1
resolver
uniprot_sec
Q9HCT1
resolver
uniprot_sec
Q9P2N8
resolver
amino_acid_sequence
MVQRMWAEAAGPAGGAEPLFPGSRRSRSVWDAVRLEVGVPDSCPVVLHSFTQLDPDLPRPESSTQEIGEELINGVIYSISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGCILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPSTELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDDRKLKIPENANVFYAMNSTANYDFVLKKRTFTKGVKVKHGASSTLPRMKQKGLKIAKGIF
uniprot
proteins
function
FUNCTION: Functions as a guanine nucleotide exchange factor (GEF) activating either RalA or RalB GTPases and plays an important role in intracellular transport. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap (By similarity). During bacterial clearance, recognizes 'Lys-33'-linked polyubiquitinated TRAF3 and subsequently mediates assembly of the exocyst complex (PubMed:27438768). {ECO:0000250|UniProtKB:Q03385, ECO:0000269|PubMed:27438768}.
uniprot
proteins
mass_dalton
100607
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Tyr-814 by MET blocks HRAS binding. {ECO:0000250|UniProtKB:Q03385}.
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
27438768
uniprot
proteins
pubmed
7972015
uniprot
proteins
pubmed
9302994
uniprot
proteins
pubmed
9365783
uniprot
proteins
sequence_length
914
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q03385}. Nucleus {ECO:0000250|UniProtKB:Q03385}. Note=Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage. Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger. After the 4-cell stage, not detected in the nucleus. {ECO:0000250|UniProtKB:Q03385}.
uniprot
proteins