Acd
entrez
307798
canonical
uniprot
Q4FZR5
canonical
ensembl
ENSRNOG00000038973
resolver
ensembl
ENSRNOG00055019389
resolver
ensembl
ENSRNOG00060011266
resolver
ensembl
ENSRNOG00065011894
resolver
ensp
ENSRNOP00000056334
resolver
ensp
ENSRNOP00055026809
resolver
ensp
ENSRNOP00060014863
resolver
ensp
ENSRNOP00065014758
resolver
enst
ENSRNOT00000059577
resolver
enst
ENSRNOT00055033083
resolver
enst
ENSRNOT00060019041
resolver
enst
ENSRNOT00065019310
resolver
genesymbol
Acd
resolver
uniprot
A0A8L2QTF0
resolver
uniprot_entry
A0A8L2QTF0_RAT
resolver
uniprot_entry
ACD_RAT
resolver
amino_acid_sequence
MSNSGRLVLRPWIRELILGSETLSSPQAGHLLKVLQDSETPGPSSAPDTPDTGAVLLVSDGTHSVRCVVTRNAIDTSDWEEKEFGFRGTEGRLLLLQACGLRIQVAQDYAPAEFYLQVDRFNLLPTEQPRVQVTGCNQDSDVQKKLNKCLEDHLSESASSSAGLTLSQLLDEVKEDGDHRGALVRLAESCLVLQGPFTARPLTHWATSCSQATEEAVFTVPSFLLHISENEEQILSSIDSSQKAQENPASPSLMPQEESGASVSLLSALPTSDPGQKDNSQPPPTVCSTSPRAQAPSSTPCSSTPSSPLLTCSPSLSPLRHAPTSYQACETRTQFHKLEFRELQWPIKRRQLLPRTGAQEPHSVWEPPERHRDTSAFQYKYGTPSASLHTQVQTARLSPQLVAWALNIVMESELPQV
uniprot
proteins
function
FUNCTION: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis. {ECO:0000250|UniProtKB:Q96AP0}.
uniprot
proteins
mass_dalton
45591
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96AP0}. Chromosome, telomere {ECO:0000250|UniProtKB:Q96AP0}.
uniprot
proteins