CIDEB
entrez
27141
canonical
uniprot
Q9UHD4
canonical
ensembl
ENSG00000136305
resolver
ensembl
ENSG00000285199
resolver
ensp
ENSP00000258807
resolver
ensp
ENSP00000337731
resolver
ensp
ENSP00000451089
resolver
ensp
ENSP00000493738
resolver
ensp
ENSP00000494868
resolver
ensp
ENSP00000495235
resolver
ensp
ENSP00000555693
resolver
ensp
ENSP00000555694
resolver
ensp
ENSP00000555695
resolver
ensp
ENSP00000555696
resolver
ensp
ENSP00000555697
resolver
ensp
ENSP00000555698
resolver
ensp
ENSP00000555699
resolver
ensp
ENSP00000555700
resolver
ensp
ENSP00000555701
resolver
ensp
ENSP00000555702
resolver
ensp
ENSP00000555703
resolver
ensp
ENSP00000555704
resolver
ensp
ENSP00000555705
resolver
ensp
ENSP00000555706
resolver
ensp
ENSP00000555707
resolver
ensp
ENSP00000555709
resolver
enst
ENST00000258807
resolver
enst
ENST00000336557
resolver
enst
ENST00000554411
resolver
enst
ENST00000642223
resolver
enst
ENST00000644519
resolver
enst
ENST00000644672
resolver
enst
ENST00000885634
resolver
enst
ENST00000885635
resolver
enst
ENST00000885636
resolver
enst
ENST00000885637
resolver
enst
ENST00000885638
resolver
enst
ENST00000885639
resolver
enst
ENST00000885640
resolver
enst
ENST00000885641
resolver
enst
ENST00000885642
resolver
enst
ENST00000885643
resolver
enst
ENST00000885644
resolver
enst
ENST00000885645
resolver
enst
ENST00000885646
resolver
enst
ENST00000885647
resolver
enst
ENST00000885648
resolver
genesymbol
CIDEB
resolver
hgnc
HGNC:1977
resolver
uniprot
D3DS73
resolver
uniprot
Q546V8
resolver
uniprot
Q9NNW9
resolver
uniprot_entry
CIDEB_HUMAN
resolver
uniprot_sec
D3DS73
resolver
uniprot_sec
Q546V8
resolver
uniprot_sec
Q9NNW9
resolver
amino_acid_sequence
MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELLAKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGLGRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLRWTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY
uniprot
proteins
function
FUNCTION: Lipid transferase specifically expressed in hepatocytes, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:35939579). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:35939579). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (By similarity). Promotes lipid exchange and lipid droplet fusion in both small and large lipid droplet-containing hepatocytes (By similarity). In addition to its role in lipid droplet fusion, also involved in cytoplasmic vesicle biogenesis and transport (By similarity). Required for very-low-density lipoprotein (VLDL) lipidation and maturation (By similarity). Probably involved in the biogenesis of VLDL transport vesicles by forming a COPII vesicle coat and facilitating the formation of endoplasmic reticulum-derived large vesicles (By similarity). Also involved in sterol-regulated export of the SCAP-SREBP complex, composed of SCAP, SREBF1/SREBP1 and SREBF2/SREBP2, by promoting loading of SCAP-SREBP into COPII vesicles (By similarity). May also activate apoptosis (PubMed:10619428). {ECO:0000250|UniProtKB:O70303, ECO:0000250|UniProtKB:P56198, ECO:0000269|PubMed:10619428, ECO:0000269|PubMed:35939579}.; FUNCTION: (Microbial infection) Involved in Hepatatis C virus (HCV) assembly and required for HCV entry into hepatocytes. {ECO:0000269|PubMed:27282740}.
uniprot
proteins
mass_dalton
24678
uniprot
proteins
protein_family
CIDE family
uniprot
proteins
pubmed
10619428
uniprot
proteins
pubmed
12429024
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
27282740
uniprot
proteins
pubmed
35939579
uniprot
proteins
pubmed
9564035
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:35939579}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O70303}; Peripheral membrane protein {ECO:0000250|UniProtKB:O70303}; Cytoplasmic side {ECO:0000250|UniProtKB:O70303}. Golgi apparatus {ECO:0000250|UniProtKB:O70303}. Cytoplasmic vesicle, COPI-coated vesicle {ECO:0000250|UniProtKB:O70303}. Note=Enriched at lipid droplet contact sites. {ECO:0000250|UniProtKB:O70303}.
uniprot
proteins