MICA
entrez
100507436
canonical
uniprot
Q29983
canonical
ensembl
ENSG00000183214
resolver
ensembl
ENSG00000204520
resolver
ensembl
ENSG00000231225
resolver
ensembl
ENSG00000233051
resolver
ensembl
ENSG00000235233
resolver
ensp
ENSP00000394553
resolver
ensp
ENSP00000402134
resolver
ensp
ENSP00000405177
resolver
ensp
ENSP00000405741
resolver
ensp
ENSP00000413079
resolver
ensp
ENSP00000416941
resolver
ensp
ENSP00000446655
resolver
ensp
ENSP00000447026
resolver
ensp
ENSP00000480992
resolver
ensp
ENSP00000482382
resolver
ensp
ENSP00000482763
resolver
ensp
ENSP00000501157
resolver
ensp
ENSP00000562179
resolver
enst
ENST00000415525
resolver
enst
ENST00000417899
resolver
enst
ENST00000418465
resolver
enst
ENST00000427477
resolver
enst
ENST00000438928
resolver
enst
ENST00000449934
resolver
enst
ENST00000546529
resolver
enst
ENST00000547767
resolver
enst
ENST00000614103
resolver
enst
ENST00000616296
resolver
enst
ENST00000616968
resolver
enst
ENST00000674069
resolver
genesymbol
MICA
resolver
genesymbol_syn
PERB11.1
resolver
hgnc
HGNC:7090
resolver
uniprot
A0A024RCL3
resolver
uniprot
A0A024RCS6
resolver
uniprot
A0A0G2JI23
resolver
uniprot
A0A0G2JJ55
resolver
uniprot
A8KQR0
resolver
uniprot
A9LRW5
resolver
uniprot
A9QVE0
resolver
uniprot
B1VJF1
resolver
uniprot
O60917
resolver
uniprot
O60918
resolver
uniprot
O60919
resolver
uniprot
O60920
resolver
uniprot
O60933
resolver
uniprot
O77956
resolver
uniprot
O78150
resolver
uniprot
O78151
resolver
uniprot
O78152
resolver
uniprot
O78153
resolver
uniprot
O97987
resolver
uniprot
O97988
resolver
uniprot
O97989
resolver
uniprot
O97990
resolver
uniprot
O97991
resolver
uniprot
O97992
resolver
uniprot
O97993
resolver
uniprot
O97994
resolver
uniprot
O97995
resolver
uniprot
O98234
resolver
uniprot
O98235
resolver
uniprot
O98236
resolver
uniprot
O98237
resolver
uniprot
O98238
resolver
uniprot
P79506
resolver
uniprot
P79507
resolver
uniprot
P79508
resolver
uniprot
P79509
resolver
uniprot
P79510
resolver
uniprot
P79511
resolver
uniprot
P79512
resolver
uniprot
P79513
resolver
uniprot
P79514
resolver
uniprot
P79515
resolver
uniprot
P79516
resolver
uniprot
P79517
resolver
uniprot
P79518
resolver
uniprot
P79519
resolver
uniprot
P79520
resolver
uniprot
P79521
resolver
uniprot
Q5C9P8
resolver
uniprot
Q5XM81
resolver
uniprot
Q70I48
resolver
uniprot
Q70I49
resolver
uniprot
Q7JFH9
resolver
uniprot
Q7JFI0
resolver
uniprot
Q7JFI1
resolver
uniprot
Q7JFI2
resolver
uniprot
Q7YQ98
resolver
uniprot
Q861I1
resolver
uniprot
Q95464
resolver
uniprot
Q95HA2
resolver
uniprot
Q95HD6
resolver
uniprot
Q95HN4
resolver
uniprot
Q95HN5
resolver
uniprot
Q95HN6
resolver
uniprot
Q95IB2
resolver
uniprot
Q95IY7
resolver
uniprot
Q96QC4
resolver
uniprot
Q99692
resolver
uniprot
Q9BCR3
resolver
uniprot
Q9BCR4
resolver
uniprot
Q9BCR5
resolver
uniprot
Q9BCR6
resolver
uniprot
Q9BCR7
resolver
uniprot
Q9BCR8
resolver
uniprot
Q9BCR9
resolver
uniprot
Q9BCS0
resolver
uniprot
Q9BCS1
resolver
uniprot
Q9BCS2
resolver
uniprot
Q9BCS3
resolver
uniprot
Q9BCS4
resolver
uniprot
Q9BD20
resolver
uniprot
Q9GIZ1
resolver
uniprot
Q9GIZ2
resolver
uniprot
Q9GIZ3
resolver
uniprot
Q9GIZ4
resolver
uniprot
Q9GIZ5
resolver
uniprot
Q9GIZ6
resolver
uniprot
Q9GJ01
resolver
uniprot
Q9GJ02
resolver
uniprot
Q9GJ03
resolver
uniprot
Q9GJ04
resolver
uniprot
Q9GJ05
resolver
uniprot
Q9GJ06
resolver
uniprot
Q9GJ07
resolver
uniprot
Q9GJ08
resolver
uniprot
Q9GJ09
resolver
uniprot
Q9MY21
resolver
uniprot
Q9TQ86
resolver
uniprot
Q9TQ87
resolver
uniprot
Q9TQ88
resolver
uniprot
Q9TQ89
resolver
uniprot
Q9TQ92
resolver
uniprot
Q9TQ93
resolver
uniprot
Q9TQ94
resolver
uniprot
Q9TQ95
resolver
uniprot
Q9TQ96
resolver
uniprot
Q9TQ97
resolver
uniprot
Q9TQ98
resolver
uniprot
Q9TQ99
resolver
uniprot
Q9TQA0
resolver
uniprot
Q9TQA1
resolver
uniprot
Q9TQA2
resolver
uniprot
Q9TQA3
resolver
uniprot
Q9TQA4
resolver
uniprot
Q9TQI9
resolver
uniprot
Q9TQJ0
resolver
uniprot
Q9TQJ1
resolver
uniprot
Q9TQJ9
resolver
uniprot
Q9TQK0
resolver
uniprot
Q9TQK1
resolver
uniprot
Q9TQK2
resolver
uniprot
Q9TQK8
resolver
uniprot
Q9TQK9
resolver
uniprot
Q9TQL0
resolver
uniprot
Q9TQL1
resolver
uniprot
Q9TQL2
resolver
uniprot
Q9TQL3
resolver
uniprot
Q9TQL4
resolver
uniprot
Q9UE04
resolver
uniprot
Q9UE05
resolver
uniprot
Q9UE06
resolver
uniprot
Q9UE11
resolver
uniprot_entry
A0A024RCL3_HUMAN
resolver
uniprot_entry
A0A0G2JI23_HUMAN
resolver
uniprot_entry
A0A0G2JJ55_HUMAN
resolver
uniprot_entry
MICA_HUMAN
resolver
uniprot_entry
Q96QC4_HUMAN
resolver
uniprot_sec
A0A024RCS6
resolver
uniprot_sec
A8KQR0
resolver
uniprot_sec
A9LRW5
resolver
uniprot_sec
A9QVE0
resolver
uniprot_sec
B1VJF1
resolver
uniprot_sec
O60917
resolver
uniprot_sec
O60918
resolver
uniprot_sec
O60919
resolver
uniprot_sec
O60920
resolver
uniprot_sec
O60933
resolver
uniprot_sec
O77956
resolver
uniprot_sec
O78150
resolver
uniprot_sec
O78151
resolver
uniprot_sec
O78152
resolver
uniprot_sec
O78153
resolver
uniprot_sec
O97987
resolver
uniprot_sec
O97988
resolver
uniprot_sec
O97989
resolver
uniprot_sec
O97990
resolver
uniprot_sec
O97991
resolver
uniprot_sec
O97992
resolver
uniprot_sec
O97993
resolver
uniprot_sec
O97994
resolver
uniprot_sec
O97995
resolver
uniprot_sec
O98234
resolver
uniprot_sec
O98235
resolver
uniprot_sec
O98236
resolver
uniprot_sec
O98237
resolver
uniprot_sec
O98238
resolver
uniprot_sec
P79506
resolver
uniprot_sec
P79507
resolver
uniprot_sec
P79508
resolver
uniprot_sec
P79509
resolver
uniprot_sec
P79510
resolver
uniprot_sec
P79511
resolver
uniprot_sec
P79512
resolver
uniprot_sec
P79513
resolver
uniprot_sec
P79514
resolver
uniprot_sec
P79515
resolver
uniprot_sec
P79516
resolver
uniprot_sec
P79517
resolver
uniprot_sec
P79518
resolver
uniprot_sec
P79519
resolver
uniprot_sec
P79520
resolver
uniprot_sec
P79521
resolver
uniprot_sec
Q5C9P8
resolver
uniprot_sec
Q5XM81
resolver
uniprot_sec
Q70I48
resolver
uniprot_sec
Q70I49
resolver
uniprot_sec
Q7JFH9
resolver
uniprot_sec
Q7JFI0
resolver
uniprot_sec
Q7JFI1
resolver
uniprot_sec
Q7JFI2
resolver
uniprot_sec
Q7YQ98
resolver
uniprot_sec
Q861I1
resolver
uniprot_sec
Q95464
resolver
uniprot_sec
Q95HA2
resolver
uniprot_sec
Q95HD6
resolver
uniprot_sec
Q95HN4
resolver
uniprot_sec
Q95HN5
resolver
uniprot_sec
Q95HN6
resolver
uniprot_sec
Q95IB2
resolver
uniprot_sec
Q95IY7
resolver
uniprot_sec
Q99692
resolver
uniprot_sec
Q9BCR3
resolver
uniprot_sec
Q9BCR4
resolver
uniprot_sec
Q9BCR5
resolver
uniprot_sec
Q9BCR6
resolver
uniprot_sec
Q9BCR7
resolver
uniprot_sec
Q9BCR8
resolver
uniprot_sec
Q9BCR9
resolver
uniprot_sec
Q9BCS0
resolver
uniprot_sec
Q9BCS1
resolver
uniprot_sec
Q9BCS2
resolver
uniprot_sec
Q9BCS3
resolver
uniprot_sec
Q9BCS4
resolver
uniprot_sec
Q9BD20
resolver
uniprot_sec
Q9GIZ1
resolver
uniprot_sec
Q9GIZ2
resolver
uniprot_sec
Q9GIZ3
resolver
uniprot_sec
Q9GIZ4
resolver
uniprot_sec
Q9GIZ5
resolver
uniprot_sec
Q9GIZ6
resolver
uniprot_sec
Q9GJ01
resolver
uniprot_sec
Q9GJ02
resolver
uniprot_sec
Q9GJ03
resolver
uniprot_sec
Q9GJ04
resolver
uniprot_sec
Q9GJ05
resolver
uniprot_sec
Q9GJ06
resolver
uniprot_sec
Q9GJ07
resolver
uniprot_sec
Q9GJ08
resolver
uniprot_sec
Q9GJ09
resolver
uniprot_sec
Q9MY21
resolver
uniprot_sec
Q9TQ86
resolver
uniprot_sec
Q9TQ87
resolver
uniprot_sec
Q9TQ88
resolver
uniprot_sec
Q9TQ89
resolver
uniprot_sec
Q9TQ92
resolver
uniprot_sec
Q9TQ93
resolver
uniprot_sec
Q9TQ94
resolver
uniprot_sec
Q9TQ95
resolver
uniprot_sec
Q9TQ96
resolver
uniprot_sec
Q9TQ97
resolver
uniprot_sec
Q9TQ98
resolver
uniprot_sec
Q9TQ99
resolver
uniprot_sec
Q9TQA0
resolver
uniprot_sec
Q9TQA1
resolver
uniprot_sec
Q9TQA2
resolver
uniprot_sec
Q9TQA3
resolver
uniprot_sec
Q9TQA4
resolver
uniprot_sec
Q9TQI9
resolver
uniprot_sec
Q9TQJ0
resolver
uniprot_sec
Q9TQJ1
resolver
uniprot_sec
Q9TQJ9
resolver
uniprot_sec
Q9TQK0
resolver
uniprot_sec
Q9TQK1
resolver
uniprot_sec
Q9TQK2
resolver
uniprot_sec
Q9TQK8
resolver
uniprot_sec
Q9TQK9
resolver
uniprot_sec
Q9TQL0
resolver
uniprot_sec
Q9TQL1
resolver
uniprot_sec
Q9TQL2
resolver
uniprot_sec
Q9TQL3
resolver
uniprot_sec
Q9TQL4
resolver
uniprot_sec
Q9UE04
resolver
uniprot_sec
Q9UE05
resolver
uniprot_sec
Q9UE06
resolver
uniprot_sec
Q9UE11
resolver
amino_acid_sequence
MGLGPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKVLVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQHPVGTSDHRDATQLGFQPLMSDLGSTGSTEGA
uniprot
proteins
disease_involvement
DISEASE: Note=Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma.; DISEASE: Psoriasis 1 (PSORS1) [MIM:177900]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). {ECO:0000269|PubMed:10323458}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells (PubMed:11491531, PubMed:11777960). Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production (PubMed:10426993). {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:11224526, ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:9497295}.
uniprot
proteins
mass_dalton
42915
uniprot
proteins
mutagenesis
MUTAGEN 47; /note="T->A: Completely restores cell surface expression of a non N-glycosylated MICA."; /evidence="ECO:0000269|PubMed:24872415"; MUTAGEN 330; /note="C->S: Complete loss of localization in cholesterol and sphingolipid-enriched microdomains; when associated with S-331."; /evidence="ECO:0000269|PubMed:21928280"; MUTAGEN 331; /note="C->S: Complete loss of localization in cholesterol and sphingolipid-enriched microdomains; when associated with S-330."; /evidence="ECO:0000269|PubMed:21928280
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation. {ECO:0000269|PubMed:8901601}.; PTM: Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation. {ECO:0000269|PubMed:12370336, ECO:0000269|PubMed:12384702}.; PTM: Palmitoylated on cysteine residues in the cytoplasmic tail leading to its association with membrane microdomains enriched in cholesterol. {ECO:0000269|PubMed:21928280}.; PTM: N-glycosylation is necessary for cell surface expression. {ECO:0000269|PubMed:24872415}.; PTM: (Microbial infection) Ubiquitinated by human herpesvirus 8 protein K5, leading to degradation. {ECO:0000269|PubMed:18230726}.
uniprot
proteins
protein_family
MHC class I family
uniprot
proteins
protein_family
MIC subfamily
uniprot
proteins
pubmed
10323458
uniprot
proteins
pubmed
10331160
uniprot
proteins
pubmed
10359807
uniprot
proteins
pubmed
10363723
uniprot
proteins
pubmed
10367903
uniprot
proteins
pubmed
10369917
uniprot
proteins
pubmed
10369920
uniprot
proteins
pubmed
10380703
uniprot
proteins
pubmed
10380704
uniprot
proteins
pubmed
10426993
uniprot
proteins
pubmed
10426994
uniprot
proteins
pubmed
10691930
uniprot
proteins
pubmed
10746789
uniprot
proteins
pubmed
10752636
uniprot
proteins
pubmed
11053635
uniprot
proteins
pubmed
11224526
uniprot
proteins
pubmed
11323699
uniprot
proteins
pubmed
11485740
uniprot
proteins
pubmed
11491531
uniprot
proteins
pubmed
11556982
uniprot
proteins
pubmed
11777960
uniprot
proteins
pubmed
11830641
uniprot
proteins
pubmed
11841487
uniprot
proteins
pubmed
12074712
uniprot
proteins
pubmed
12370336
uniprot
proteins
pubmed
12384702
uniprot
proteins
pubmed
12466900
uniprot
proteins
pubmed
12542746
uniprot
proteins
pubmed
12902493
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15104678
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15995699
uniprot
proteins
pubmed
16634869
uniprot
proteins
pubmed
16750166
uniprot
proteins
pubmed
17495932
uniprot
proteins
pubmed
17565371
uniprot
proteins
pubmed
18202175
uniprot
proteins
pubmed
18230726
uniprot
proteins
pubmed
18287244
uniprot
proteins
pubmed
19793804
uniprot
proteins
pubmed
21928280
uniprot
proteins
pubmed
24872415
uniprot
proteins
pubmed
7927538
uniprot
proteins
pubmed
8022771
uniprot
proteins
pubmed
8613147
uniprot
proteins
pubmed
8781120
uniprot
proteins
pubmed
8901601
uniprot
proteins
pubmed
9396860
uniprot
proteins
pubmed
9497295
uniprot
proteins
sequence_length
383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:21928280, ECO:0000269|PubMed:8901601}; Single-pass type I membrane protein {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}. Cytoplasm {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}. Note=Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum. {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}.
uniprot
proteins
transmembrane_region
TRANSMEM 308..328; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins