Glra1
entrez
25674
canonical
uniprot
P07727
canonical
ensembl
ENSRNOG00000013588
resolver
ensp
ENSRNOP00000063384
resolver
genesymbol
Glra1
resolver
genesymbol_syn
Glyr
resolver
uniprot
A0A096MIV2
resolver
uniprot
Q546L6
resolver
uniprot
Q546L7
resolver
uniprot_entry
GLRA1_RAT
resolver
uniprot_entry
Q546L7_RAT
resolver
uniprot_sec
A0A096MIV2
resolver
uniprot_sec
Q546L6
resolver
activity_regulation
ACTIVITY REGULATION: Channel opening is triggered by extracellular glycine. Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization. Channel opening is also triggered by taurine and beta-alanine (PubMed:1716350). Inhibited by strychnine (PubMed:1716350, PubMed:2483325, PubMed:3037383). Inhibited by picrotoxin (PubMed:2483325). {ECO:0000269|PubMed:1716350, ECO:0000269|PubMed:2483325, ECO:0000269|PubMed:3037383}.
uniprot
proteins
amino_acid_sequence
MYSFNTLRFYLWETIVFFSLAASKEADAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQDDEGGEGRFNFSAYGMGPACLQAKDGISVKGANNNNTTNPAPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNK
uniprot
proteins
function
FUNCTION: Subunit of heteromeric glycine-gated chloride channels (PubMed:11981023, PubMed:1716350, PubMed:2483325, PubMed:3037383). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity). {ECO:0000250|UniProtKB:P23415, ECO:0000250|UniProtKB:Q64018, ECO:0000269|PubMed:11981023, ECO:0000269|PubMed:1716350, ECO:0000269|PubMed:2483325, ECO:0000269|PubMed:3037383}.
uniprot
proteins
mass_dalton
52617
uniprot
proteins
protein_family
GLRA1 sub-subfamily
uniprot
proteins
protein_family
Glycine receptor (TC 1.A.9.3) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
11981023
uniprot
proteins
pubmed
14551753
uniprot
proteins
pubmed
1703526
uniprot
proteins
pubmed
1716350
uniprot
proteins
pubmed
2171639
uniprot
proteins
pubmed
2483325
uniprot
proteins
pubmed
3037383
uniprot
proteins
pubmed
6286620
uniprot
proteins
sequence_length
457
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:6286620}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q64018}. Synapse {ECO:0000269|PubMed:6286620}. Perikaryon {ECO:0000250|UniProtKB:Q64018}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q64018}. Cell membrane {ECO:0000269|PubMed:11981023, ECO:0000269|PubMed:1716350, ECO:0000269|PubMed:2483325, ECO:0000269|PubMed:3037383}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}.
uniprot
proteins
transmembrane_region
TRANSMEM 251..272; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O93430"; TRANSMEM 278..298; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O93430"; TRANSMEM 310..330; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O93430"; TRANSMEM 426..446; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O93430
uniprot
proteins