Slc2a1
entrez
24778
canonical
uniprot
P11167
canonical
ensembl
ENSRNOG00000007284
resolver
ensembl
ENSRNOG00055013182
resolver
ensembl
ENSRNOG00060016008
resolver
ensembl
ENSRNOG00065017523
resolver
ensp
ENSRNOP00000061340
resolver
ensp
ENSRNOP00055018357
resolver
ensp
ENSRNOP00060022060
resolver
ensp
ENSRNOP00065023261
resolver
enst
ENSRNOT00000064452
resolver
enst
ENSRNOT00055022600
resolver
enst
ENSRNOT00060027472
resolver
enst
ENSRNOT00065029315
resolver
genesymbol
Slc2a1
resolver
genesymbol_syn
Glut1
resolver
uniprot_entry
GTR1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: The uptake of glucose is inhibited by cytochalasin B. Glucose uptake is increased in response to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment: TPA-induced glucose uptake requires phosphorylation at Ser-226. {ECO:0000250|UniProtKB:P11166}.
uniprot
proteins
amino_acid_sequence
MEPSSKKVTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWNHRYGESIPSTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNADLWPLLLSVIFIPALLQCILLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTRDLQEMKEEGRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAVLMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAVAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
uniprot
proteins
function
FUNCTION: Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:2211693). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (By similarity). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity). {ECO:0000250|UniProtKB:P11166, ECO:0000250|UniProtKB:P17809, ECO:0000250|UniProtKB:P46896, ECO:0000269|PubMed:2211693}.
uniprot
proteins
mass_dalton
53963
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-226 by PKC promotes glucose uptake by increasing cell membrane localization. {ECO:0000250|UniProtKB:P11166}.
uniprot
proteins
protein_family
Glucose transporter subfamily
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sugar transporter (TC 2.A.1.1) family
uniprot
proteins
pubmed
10198040
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15708368
uniprot
proteins
pubmed
21076856
uniprot
proteins
pubmed
2211693
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
3016720
uniprot
proteins
pubmed
3198639
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2211693}; Multi-pass membrane protein {ECO:0000255}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P17809}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..33; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 67..87; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 91..112; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 121..144; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 156..176; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 186..206; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 272..293; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 307..328; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 335..355; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 366..388; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 402..422; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P11166"; TRANSMEM 430..450; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P11166
uniprot
proteins