KIF2A
entrez
3796
canonical
uniprot
O00139
canonical
ensembl
ENSG00000068796
resolver
ensp
ENSP00000370493
resolver
ensp
ENSP00000385000
resolver
ensp
ENSP00000385622
resolver
ensp
ENSP00000501719
resolver
enst
ENST00000676271
resolver
genesymbol
KIF2A
resolver
genesymbol_syn
KIF2
resolver
genesymbol_syn
KNS2
resolver
hgnc
HGNC:6318
resolver
uniprot
A0A6Q8PFA6
resolver
uniprot
A5YM42
resolver
uniprot
A5YM54
resolver
uniprot
B0AZS5
resolver
uniprot
B4DY54
resolver
uniprot
D3DW97
resolver
uniprot
E9PB70
resolver
uniprot
Q7Z5I3
resolver
uniprot
Q8N5Q7
resolver
uniprot_entry
A0A6Q8PFA6_HUMAN
resolver
uniprot_entry
B0AZS5_HUMAN
resolver
uniprot_entry
KIF2A_HUMAN
resolver
uniprot_sec
A5YM42
resolver
uniprot_sec
A5YM54
resolver
uniprot_sec
B4DY54
resolver
uniprot_sec
D3DW97
resolver
uniprot_sec
E9PB70
resolver
uniprot_sec
Q7Z5I3
resolver
uniprot_sec
Q8N5Q7
resolver
amino_acid_sequence
MATANFGKIQIGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWIENGDTKGKEIDLESIFSLNPDLVPDEEIEPSPETPPPPASSAKVNKIVKNRRTVASIKNDPPSRDNRVVGSARARPSQFPEQSSSAQQNGSVSDISPVQAAKKEFGPPSRRKSNCVKEVEKLQEKREKRRLQQQELREKRAQDVDATNPNYEIMCMIRDFRGSLDYRPLTTADPIDEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKTKLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRKGKLHGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRVKELTVDPTAAGDVRPIMHHPPNQIDDLETQWGVGSSPQRDDLKLLCEQNEEEVSPQLFTFHEAVSQMVEMEEQVVEDHRAVFQESIRWLEDEKALLEMTEEVDYDVDSYATQLEAILEQKIDILTELRDKVKSFRAALQEEEQASKQINPKRPRAL
uniprot
proteins
disease_involvement
DISEASE: Cortical dysplasia, complex, with other brain malformations 3 (CDCBM3) [MIM:615411]: A disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include early-onset epilepsy, and various malformations of cortical development such as agyria, posterior or frontal pachygyria, subcortical band heterotopia, and thin corpus callosum. {ECO:0000269|PubMed:23603762}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:30785839}.
uniprot
proteins
mass_dalton
79955
uniprot
proteins
protein_family
Kinesin family
uniprot
proteins
protein_family
MCAK/KIF2 subfamily
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15843429
uniprot
proteins
pubmed
17538014
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18411309
uniprot
proteins
pubmed
19351716
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23603762
uniprot
proteins
pubmed
30785839
uniprot
proteins
pubmed
9177777
uniprot
proteins
sequence_length
706
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:30785839}. Cytoplasm, cytoskeleton, spindle. Note=Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1.
uniprot
proteins