SENP7
entrez
57337
canonical
uniprot
Q9BQF6
canonical
ensembl
ENSG00000138468
resolver
ensp
ENSP00000313624
resolver
ensp
ENSP00000342159
resolver
ensp
ENSP00000377651
resolver
ensp
ENSP00000377654
resolver
ensp
ENSP00000377655
resolver
ensp
ENSP00000628747
resolver
ensp
ENSP00000687091
resolver
enst
ENST00000394094
resolver
genesymbol
SENP7
resolver
genesymbol_syn
KIAA1707
resolver
genesymbol_syn
SSP2
resolver
genesymbol_syn
SUSP2
resolver
hgnc
HGNC:30402
resolver
uniprot
A1L3A5
resolver
uniprot
A8MW39
resolver
uniprot
B7WNW8
resolver
uniprot
J3QT09
resolver
uniprot
Q7Z3F4
resolver
uniprot
Q96PS5
resolver
uniprot
Q9C0F6
resolver
uniprot
Q9HBT5
resolver
uniprot_entry
J3QT09_HUMAN
resolver
uniprot_entry
SENP7_HUMAN
resolver
uniprot_sec
A1L3A5
resolver
uniprot_sec
A8MW39
resolver
uniprot_sec
B7WNW8
resolver
uniprot_sec
Q7Z3F4
resolver
uniprot_sec
Q96PS5
resolver
uniprot_sec
Q9C0F6
resolver
uniprot_sec
Q9HBT5
resolver
amino_acid_sequence
MDKRKLGRRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSERWTLPLQWERSLRNKVISLDHKNKKHIRGCPVTSKSSPERQLKVMLTNVLWTDLGRKFRKTLPRNDANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERIPRVILTNVLGTELGRKYIRTPPVTEGSLSDTDNLQSEQLSSSSDGSLESYQNLNPHKSCYLSERGSQRSKTVDDNSAKQTAHNKEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFTKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPILRGHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSESALLELPLITCESVQMSSELCPYNPVMENISSIMPSNEMDLQLDFIFTSVYIGKIKGASKGCVTITKKYIKIPFQVSLNEISLLVDTTHLKRFGLWKSKDDNHSKRSHAILFFWVSSDYLQEIQTQLEHSVLSQQSKSSEFIFLELHNPVSQREELKLKDIMTEISIISGELELSYPLSWVQAFPLFQNLSSKESSFIHYYCVSTCSFPAGVAVAEEMKLKSVSQPSNTDAAKPTYTFLQKQSSGCYSLSITSNPDEEWREVRHTGLVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIIDFYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPNLSMAQRRHKRVRTWTRHINIFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDFPQTVSQQSQAQQSQNDNKTIDNDLRTTSTLSLSAEDSQSTESNMSVPKKMCKRPCILILDSLKAASVQNTVQNLREYLEVEWEVKLKTHRQFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFKDPIVNFELPIHLEKWFPRHVIKTKREDIRELILKLHLQQQKGSSS
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
function
FUNCTION: Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). {ECO:0000250|UniProtKB:Q8BUH8, ECO:0000269|PubMed:18799455}.
uniprot
proteins
mass_dalton
119658
uniprot
proteins
mutagenesis
MUTAGEN 775; /note="F->W: Slightly increased deconjugation activity."; /evidence="ECO:0000269|PubMed:18799455"; MUTAGEN 779; /note="V->E: Reduces deconjugation activity."; /evidence="ECO:0000269|PubMed:18799455
uniprot
proteins
protein_family
Peptidase C48 family
uniprot
proteins
pubmed
11214970
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18799455
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
1050
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BUH8}.
uniprot
proteins