NOXA1
entrez
10811
canonical
uniprot
Q86UR1
canonical
ensembl
ENSG00000188747
resolver
ensp
ENSP00000342848
resolver
ensp
ENSP00000376562
resolver
ensp
ENSP00000507846
resolver
ensp
ENSP00000637063
resolver
ensp
ENSP00000702775
resolver
genesymbol
NOXA1
resolver
genesymbol_syn
P51NOX
resolver
hgnc
HGNC:10668
resolver
uniprot
O60533
resolver
uniprot
Q29VU9
resolver
uniprot
Q29VV0
resolver
uniprot
Q2TAM1
resolver
uniprot
Q8IUS3
resolver
uniprot_entry
NOXA1_HUMAN
resolver
uniprot_sec
O60533
resolver
uniprot_sec
Q29VU9
resolver
uniprot_sec
Q29VV0
resolver
uniprot_sec
Q2TAM1
resolver
uniprot_sec
Q8IUS3
resolver
amino_acid_sequence
MASLGDLVRAWHLGAQAVDRGDWARALHLFSGVPAPPARLCFNAGCVHLLAGDPEAALRAFDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQLRGHAAIDYTQLGLRFKLQAWEVLHNVASAQCQLGLWTEAASSLREAMSKWPEGSLNGLDSALDQVQRRGSLPPRQVPRGEVFRPHRWHLKHLEPVDFLGKAKVVASAIPDDQGWGVRPQQPQGPGANHDARSLIMDSPRAGTHQGPLDAETEVGADRCTSTAYQEQRPQVEQVGKQAPLSPGLPAMGGPGPGPCEDPAGAGGAGAGGSEPLVTVTVQCAFTVALRARRGADLSSLRALLGQALPHQAQLGQLSYLAPGEDGHWVPIPEEESLQRAWQDAAACPRGLQLQCRGAGGRPVLYQVVAQHSYSAQGPEDLGFRQGDTVDVLCEVDQAWLEGHCDGRIGIFPKCFVVPAGPRMSGAPGRLPRSQQGDQP
uniprot
proteins
function
FUNCTION: Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:12716910, ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:14978110, ECO:0000269|PubMed:15181005, ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:17602954, ECO:0000269|PubMed:19755710}.
uniprot
proteins
mass_dalton
50933
uniprot
proteins
mutagenesis
MUTAGEN 34; /note="P->A: Partial loss of function."; /evidence="ECO:0000269|PubMed:17602954"; MUTAGEN 37; /note="P->A: Partial loss of function."; /evidence="ECO:0000269|PubMed:17602954"; MUTAGEN 68; /note="D->A: Loss of function and loss of interaction with RAC1."; /evidence="ECO:0000269|PubMed:16636067"; MUTAGEN 103; /note="R->E: Loss of function and loss of interaction with RAC1. Loss of localization to membranes."; /evidence="ECO:0000269|PubMed:12716910, ECO:0000269|PubMed:16636067, ECO:0000269|PubMed:16762923"; MUTAGEN 172; /note="S->A: Loss of phosphorylation. Loss of interaction with YHAWZ; when associated with A-461."; /evidence="ECO:0000269|PubMed:17913709"; MUTAGEN 172; /note="S->E: Constitutively interacts with YWHAZ; when associated with E-461."; /evidence="ECO:0000269|PubMed:17913709"; MUTAGEN 205; /note="V->A: Unable to activate NOX2."; /evidence="ECO:0000269|PubMed:15181005"; MUTAGEN 436; /note="W->R: Loss of interaction with NOXO1 and NCF1. Loss of localization to membranes. Partial loss of function."; /evidence="ECO:0000269|PubMed:12716910, ECO:0000269|PubMed:16762923, ECO:0000269|PubMed:17602954"; MUTAGEN 461; /note="S->A: Loss of phosphorylation. Loss of interaction with YHAWZ; when associated with A-172."; /evidence="ECO:0000269|PubMed:17913709"; MUTAGEN 461; /note="S->E: Constitutively interacts with YWHAZ; when associated with E-172."; /evidence="ECO:0000269|PubMed:17913709
uniprot
proteins
post_translational_modification
PTM: Interaction with YWHAZ depends on phosphorylation by PKA. {ECO:0000269|PubMed:17913709}.
uniprot
proteins
protein_family
NCF2/NOXA1 family
uniprot
proteins
pubmed
12657628
uniprot
proteins
pubmed
12716910
uniprot
proteins
pubmed
14617635
uniprot
proteins
pubmed
14978110
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15181005
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15824103
uniprot
proteins
pubmed
16329988
uniprot
proteins
pubmed
16507994
uniprot
proteins
pubmed
16636067
uniprot
proteins
pubmed
16762923
uniprot
proteins
pubmed
17126813
uniprot
proteins
pubmed
17602954
uniprot
proteins
pubmed
17913709
uniprot
proteins
pubmed
19755710
uniprot
proteins
pubmed
20609497
uniprot
proteins
pubmed
9610721
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
uniprot
proteins