SLC6A13
entrez
6540
canonical
uniprot
Q9NSD5
canonical
ensembl
ENSG00000010379
resolver
ensp
ENSP00000339260
resolver
ensp
ENSP00000389316
resolver
ensp
ENSP00000407104
resolver
genesymbol
SLC6A13
resolver
genesymbol_syn
GAT2
resolver
hgnc
HGNC:11046
resolver
uniprot
B4DJL1
resolver
uniprot
Q8TCC2
resolver
uniprot
Q8WW56
resolver
uniprot_entry
S6A13_HUMAN
resolver
uniprot_sec
B4DJL1
resolver
uniprot_sec
Q8TCC2
resolver
uniprot_sec
Q8WW56
resolver
activity_regulation
ACTIVITY REGULATION: GABA transport is inhibited by beta-alanine, 2,3-diaminopropionic acid and SNAP-5114. {ECO:0000269|PubMed:17502375}.
uniprot
proteins
amino_acid_sequence
MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTELESHC
uniprot
proteins
function
FUNCTION: Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:17502375, PubMed:22932902). Mediates transport of beta-alanine (PubMed:17502375). Can also mediate transport of taurine and hypotaurine (By similarity). {ECO:0000250|UniProtKB:P31649, ECO:0000269|PubMed:17502375, ECO:0000269|PubMed:22932902}.
uniprot
proteins
mass_dalton
68009
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="E->A: 50% reduction of GABA-uptake."; /evidence="ECO:0000269|PubMed:22932902"; MUTAGEN 48; /note="E->L,Y: 90% reduction of GABA-uptake."; /evidence="ECO:0000269|PubMed:22932902"; MUTAGEN 51; /note="G->A,L: Complete loss of GABA-uptake."; /evidence="ECO:0000269|PubMed:22932902"; MUTAGEN 132; /note="V->I: Complete loss of GABA-uptake."; /evidence="ECO:0000269|PubMed:22932902
uniprot
proteins
protein_family
SLC6A13 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
11824941
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17502375
uniprot
proteins
pubmed
22932902
uniprot
proteins
sequence_length
602
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22932902}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P31649}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 41..61; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 68..88; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 121..141; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 282..302; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 319..339; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 366..386; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 418..438; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 453..473; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 490..510; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 528..548; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins