Sqle
entrez
20775
canonical
uniprot
P52019
canonical
ensembl
ENSMUSG00000022351
resolver
ensp
ENSMUSP00000022977
resolver
enst
ENSMUST00000022977
resolver
genesymbol
Sqle
resolver
genesymbol_syn
Erg1
resolver
uniprot
Q3TQK8
resolver
uniprot_entry
ERG1_MOUSE
resolver
uniprot_entry
Q3TQK8_MOUSE
resolver
amino_acid_sequence
MWTFLGIATFTYFYKKCGDVTLANKELLLCVLVFLSLGLVLSYRCRHRHGGLLGRHQSGAQFAAFSDILSALPLIGFFWAKSPESEKKEQLESKKCRKEIGLSETTLTGAATSVSTSFVTDPEVIIVGSGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGELLQPGGYRVLQELGLGDTVEGLNAHHIHGYIVHDYESRSEVQIPYPLSETNQVQSGIAFHHGRFIMSLRKAAMAEPNVKFIEGVVLQLLEEDDAVIGVQYKDKETGDTKELHAPLTVVADGLFSKFRKSLISSKVSVSSHFVGFLMKDAPQFKPNFAELVLVNPSPVLIYQISSSETRVLVDIRGELPRNLREYMAEQIYPQLPEHLKESFLEASQNGRLRTMPASFLPPSSVNKRGVLILGDAYNLRHPLTGGGMTVALKDIKLWRQLLKDIPDLYDDAAIFQAKKSFFWSRKRTHSFVVNVLAQALYELFSATDDSLHQLRKACFLYFKLGGECVTGPVGLLSILSPHPLVLIRHFFSVAIYATYFCFKSEPWATKPRALFSSGAVLYKACSILFPLIYSEMKYLVH
uniprot
proteins
ec_number
1.14.14.17
uniprot
proteins
function
FUNCTION: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. {ECO:0000250|UniProtKB:P52020}.
uniprot
proteins
mass_dalton
63770
uniprot
proteins
pathway_participation
PATHWAY: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3. {ECO:0000250|UniProtKB:Q14534}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MARCHF6 in response to high cholesterol levels in intracellular membranes, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q14534}.
uniprot
proteins
protein_family
Squalene monooxygenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7873613
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:P52020}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14534}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q14534}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14534}.
uniprot
proteins