Ikzf4
entrez
22781
canonical
uniprot
Q8C208
canonical
ensembl
ENSMUSG00000002578
resolver
ensp
ENSMUSP00000114404
resolver
ensp
ENSMUSP00000152234
resolver
ensp
ENSMUSP00000158614
resolver
ensp
ENSMUSP00000158702
resolver
enst
ENSMUST00000238610
resolver
enst
ENSMUST00000238712
resolver
genesymbol
Ikzf4
resolver
genesymbol_syn
Zfpn1a4
resolver
uniprot
A0A571BEH5
resolver
uniprot
B9EJ21
resolver
uniprot
Q3TCZ7
resolver
uniprot
Q9Z2Z2
resolver
uniprot_entry
A0A571BEH5_MOUSE
resolver
uniprot_entry
IKZF4_MOUSE
resolver
uniprot_sec
B9EJ21
resolver
uniprot_sec
Q3TCZ7
resolver
uniprot_sec
Q9Z2Z2
resolver
amino_acid_sequence
MHTPPALPRRFQGGGRVRTPGSHRQGKDNLERELSGGCAPDFLPQAQDSNHFIMESLFCESSGDSSLEKEFLGAPVGPSVSTPNSQHSSPSRSLSANSIKVEMYSDEESSRLLGPDERLLDKDDSVIVEDSLSEPLGYCDGSGPEPHSPGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCNYACRRRDALTGHLRTHSVSSPTVGKPYKCNYCGRSYKQQSTLEEHKERCHNYLQSLSTDAQALTGQPGDEIRDLEMVPDSMLHPSTERPTFIDRLANSLTKRKRSTPQKFVGEKQMRFSLSDLPYDVNASGGYEKDVELVAHHGLEPGFGGSLAFVGTEHLRPLRLPPTNCISELTPVISSVYTQMQPIPSRLELPGSREAGEGPEDLGDGGPLLYRARGSLTDPGASPSNGCQDSTDTESNHEDRIGGVVSLPQGPPPQPPPTIVVGRHSPAYAKEDPKPQEGLLRGTPGPSKEVLRVVGESGEPVKAFKCEHCRILFLDHVMFTIHMGCHGFRDPFECNICGYHSQDRYEFSSHIVRGEHKVG
uniprot
proteins
function
FUNCTION: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (PubMed:19696312). {ECO:0000269|PubMed:10218586, ECO:0000269|PubMed:17403896, ECO:0000269|PubMed:19696312}.
uniprot
proteins
mass_dalton
64155
uniprot
proteins
protein_family
Ikaros C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
10218586
uniprot
proteins
pubmed
12444977
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17403896
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19696312
uniprot
proteins
sequence_length
586
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins