Gls
entrez
24398
canonical
uniprot
P13264
canonical
ensembl
ENSRNOG00000056246
resolver
ensp
ENSRNOP00000071972
resolver
ensp
ENSRNOP00000075466
resolver
enst
ENSRNOT00000078073
resolver
enst
ENSRNOT00000090026
resolver
genesymbol
Gls
resolver
uniprot
A0A0G2K1T0
resolver
uniprot
A0A0G2KAN7
resolver
uniprot
Q8R421
resolver
uniprot_entry
A0A0G2K1T0_RAT
resolver
uniprot_entry
A0A0G2KAN7_RAT
resolver
uniprot_entry
GLSK_RAT
resolver
uniprot_sec
Q8R421
resolver
activity_regulation
ACTIVITY REGULATION: Enzyme activity is increased by phosphate, due to increased kcat and increased substrate affinity. {ECO:0000269|PubMed:1991024, ECO:0000269|PubMed:22228304}.
uniprot
proteins
amino_acid_sequence
MMRLRGSAMLRELLLRPPAAVGGVLRRTQPLGTLCRRPRGGSRPAAGLVAAARLHPWWGGGGRAKGPGSGGLSSSPSEILQELGKGGTPPQQQQQQQQQPGASPPAAPGPKDSPGETDAFGNSEGKEMVAAGDNKVKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSIGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDDGKENQTVHKNLDGLL
uniprot
proteins
ec_number
3.5.1.2
uniprot
proteins
function
FUNCTION: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain. {ECO:0000250|UniProtKB:D3Z7P3}.
uniprot
proteins
mass_dalton
74024
uniprot
proteins
post_translational_modification
PTM: Synthesized as a 74-kDa cytosolic precursor which is proteolytically processed by the mitochondrial-processing peptidase (MPP) via a 72-kDa intermediate to yield the mature mitochondrial 68- and 65-kDa subunits. {ECO:0000269|PubMed:1918000, ECO:0000269|PubMed:1991024, ECO:0000269|PubMed:7836378}.
uniprot
proteins
protein_family
Glutaminase family
uniprot
proteins
pubmed
11267668
uniprot
proteins
pubmed
12045296
uniprot
proteins
pubmed
16899818
uniprot
proteins
pubmed
1918000
uniprot
proteins
pubmed
1991024
uniprot
proteins
pubmed
22228304
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23935106
uniprot
proteins
pubmed
3401701
uniprot
proteins
pubmed
7836378
uniprot
proteins
sequence_length
674
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:1991024}. Cytoplasm, cytosol {ECO:0000269|PubMed:1991024}. Note=The 74-kDa cytosolic precursor is translocated into the mitochondria and processed via a 72-kDa intermediate to yield the mature 68 and 65-kDa subunits. {ECO:0000269|PubMed:1991024}.; SUBCELLULAR LOCATION: [Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix {ECO:0000269|PubMed:1991024, ECO:0000269|PubMed:7836378}. Note=Produced by the proteolytic processing of the 74-kDa cytosolic precursor. {ECO:0000269|PubMed:1991024, ECO:0000269|PubMed:7836378}.; SUBCELLULAR LOCATION: [Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix {ECO:0000269|PubMed:1991024, ECO:0000269|PubMed:7836378}. Note=Produced by the proteolytic processing of the 74-kDa cytosolic precursor. {ECO:0000269|PubMed:1991024, ECO:0000269|PubMed:7836378}.
uniprot
proteins