Sgpp1
entrez
81535
canonical
uniprot
Q9JI99
canonical
ensembl
ENSMUSG00000021054
resolver
ensp
ENSMUSP00000021450
resolver
enst
ENSMUST00000021450
resolver
genesymbol
Sgpp1
resolver
genesymbol_syn
Spp1
resolver
genesymbol_syn
Spph1
resolver
uniprot
Q3UDY2
resolver
uniprot_entry
Q3UDY2_MOUSE
resolver
uniprot_entry
SGPP1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by NaF, sodium orthovanadate, propanolol, and N-ethylmaleimide. {ECO:0000269|PubMed:11756451}.
uniprot
proteins
amino_acid_sequence
MSLGQRLALLASRLQEPQRVASFQRLCGVEVPLSSPAADEDAETEVRGAPGEPRRRGRQPGAEDSPAKADCCGAPNGVRNGLAAEPGPTGPRRAGSQRRNSLTGEEGELVKVSNLPLYYLFCLGTELGNELFYILFFPFWIWNLDPFVGRRLVIIWVLVMYLGQCTKDIIRWPRPASPPVIKLEVFYNSEYSMPSTHAMSGTAIPIAMFLLTYGRWQYPLIYGLILIPCWSSLVCLSRIYMGMHSILDVIAGFLYTILILIIFYPLVDLIDNFNQTYKYAPLIIIGLHLILGIFSFTLDTWSTSRGDTAEILGSGAGIACGSHAAYTLGLSLEPSLHMLPLAIPPLTVTLFGKAILRIVLGMLLVLFVRDIMKKITIPLACKLSSIPCHDIRQARQHMEVELPYRYITYGMVGFSITFLVPYVFSFIGIS
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
function
FUNCTION: Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P (PubMed:10859351, PubMed:11756451). Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid. Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway. Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:10859351, Ref.2). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase (PubMed:12235122, PubMed:17895250). In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (PubMed:17895250). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus (By similarity). The modulation of intracellular ceramide levels in turn regulates apoptosis (PubMed:12235122). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries. Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (By similarity). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (PubMed:23637227). {ECO:0000250|UniProtKB:Q9BX95, ECO:0000269|PubMed:10859351, ECO:0000269|PubMed:11756451, ECO:0000269|PubMed:12235122, ECO:0000269|PubMed:17895250, ECO:0000269|PubMed:23637227}.
uniprot
proteins
mass_dalton
47744
uniprot
proteins
protein_family
Type 2 lipid phosphate phosphatase family
uniprot
proteins
pubmed
10859351
uniprot
proteins
pubmed
11756451
uniprot
proteins
pubmed
12235122
uniprot
proteins
pubmed
12411432
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17895250
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23637227
uniprot
proteins
sequence_length
430
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12235122}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:12235122}; Multi-pass membrane protein {ECO:0000255}. Note=Mainly found in intracellular membrane fractions. {ECO:0000269|PubMed:12235122}.
uniprot
proteins
transmembrane_region
TRANSMEM 121..141; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 152..172; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 216..236; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 246..266; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 279..299; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 348..368; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 409..429; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins