LGALS13
entrez
29124
canonical
uniprot
Q9UHV8
canonical
ensembl
ENSG00000105198
resolver
ensp
ENSP00000221797
resolver
ensp
ENSP00000774036
resolver
enst
ENST00000221797
resolver
genesymbol
LGALS13
resolver
genesymbol_syn
PLAC8
resolver
hgnc
HGNC:15449
resolver
uniprot
C5HZ15
resolver
uniprot_entry
PP13_HUMAN
resolver
uniprot_sec
C5HZ15
resolver
amino_acid_sequence
MSSLPVPYKLPVSLSVGSCVIIKGTPIHSFINDPQLQVDFYTDMDEDSDIAFRFRVHFGNHVVMNRREFGIWMLEETTDYVPFEDGKQFELCIYVHYNEYEIKVNGIRIYGFVHRIPPSFVKMVQVSRDISLTSVCVCN
uniprot
proteins
function
FUNCTION: Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis (PubMed:10527825, PubMed:19497882). Has hemagglutinating activity towards chicken erythrocytes (PubMed:29343868). Acts as an activator of ferroptosis: secreted by ferroptotic cells and acts by reducing localization of SLC7A11 at the plasma membrane (PubMed:40246981). {ECO:0000269|PubMed:10527825, ECO:0000269|PubMed:19497882, ECO:0000269|PubMed:29343868, ECO:0000269|PubMed:40246981}.
uniprot
proteins
mass_dalton
16119
uniprot
proteins
mutagenesis
MUTAGEN 53; /note="R->H: No effect on its haemagglutinating activity."; /evidence="ECO:0000269|PubMed:29343868"; MUTAGEN 136; /note="C->S: Loss of homodimerization; when associated with S-138."; /evidence="ECO:0000269|PubMed:29343868"; MUTAGEN 138; /note="C->S: Loss of homodimerization; when associated with S-136."; /evidence="ECO:0000269|PubMed:29343868
uniprot
proteins
pubmed
10527825
uniprot
proteins
pubmed
11742106
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19497882
uniprot
proteins
pubmed
29343868
uniprot
proteins
pubmed
40246981
uniprot
proteins
pubmed
6856484
uniprot
proteins
sequence_length
139
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29343868}. Nucleus matrix {ECO:0000269|PubMed:29343868}. Secreted {ECO:0000269|PubMed:40246981}. Note=Secreted by ferroptotic cells. {ECO:0000269|PubMed:40246981}.
uniprot
proteins