SAT1
entrez
6303
canonical
uniprot
P21673
canonical
ensembl
ENSG00000130066
resolver
ensp
ENSP00000368572
resolver
enst
ENST00000379270
resolver
genesymbol
SAT1
resolver
genesymbol_syn
SAT
resolver
hgnc
HGNC:10540
resolver
uniprot
A0A384NQ10
resolver
uniprot
Q6ICU9
resolver
uniprot_entry
A0A384NQ10_HUMAN
resolver
uniprot_entry
SAT1_HUMAN
resolver
uniprot_sec
Q6ICU9
resolver
amino_acid_sequence
MAKFVIRPATAADCSDILRLIKELAKYEYMEEQVILTEKDLLEDGFGEHPFYHCLVAEVPKEHWTPEGHSIVGFAMYYFTYDPWIGKLLYLEDFFVMSDYRGFGIGSEILKNLSQVAMRCRCSSMHFLVAEWNEPSINFYKRRGASDLSSEEGWRLFKIDKEYLLKMATEE
uniprot
proteins
disease_involvement
DISEASE: Note=Overexpression of SAT1 and the consequent putrescine accumulation might play a role in the pathogenesis of keratosis follicularis spinulosa decalvans. {ECO:0000269|PubMed:12215835}.
uniprot
proteins
ec_number
2.3.1.57
uniprot
proteins
function
FUNCTION: Enzyme which catalyzes the acetylation of polyamines (PubMed:15283699, PubMed:16455797, PubMed:17516632). Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine (PubMed:17516632). This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines (PubMed:16455797). Also involved in the regulation of polyamine transport out of cells (PubMed:16455797). Also acts on 1,3-diaminopropane and 1,5-diaminopentane (PubMed:16455797, PubMed:17516632). {ECO:0000269|PubMed:15283699, ECO:0000269|PubMed:16455797, ECO:0000269|PubMed:17516632}.
uniprot
proteins
mass_dalton
20024
uniprot
proteins
mutagenesis
MUTAGEN 140; /note="Y->F: Reduces activity by 95%."; /evidence="ECO:0000269|PubMed:16455797
uniprot
proteins
pathway_participation
PATHWAY: Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1. {ECO:0000269|PubMed:16455797, ECO:0000269|PubMed:17516632}.
uniprot
proteins
protein_family
Acetyltransferase family
uniprot
proteins
pubmed
12215835
uniprot
proteins
pubmed
1417826
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15283699
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16455797
uniprot
proteins
pubmed
1652956
uniprot
proteins
pubmed
16544326
uniprot
proteins
pubmed
17516632
uniprot
proteins
pubmed
1985966
uniprot
proteins
pubmed
2241897
uniprot
proteins
pubmed
8573111
uniprot
proteins
sequence_length
171
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:1985966, ECO:0000305|PubMed:2241897}.
uniprot
proteins