LGMN
entrez
5641
canonical
uniprot
Q99538
canonical
ensembl
ENSG00000100600
resolver
ensp
ENSP00000334052
resolver
ensp
ENSP00000376911
resolver
ensp
ENSP00000451861
resolver
ensp
ENSP00000452572
resolver
ensp
ENSP00000532088
resolver
ensp
ENSP00000622436
resolver
ensp
ENSP00000622440
resolver
ensp
ENSP00000664689
resolver
ensp
ENSP00000664695
resolver
ensp
ENSP00000683586
resolver
genesymbol
LGMN
resolver
genesymbol_syn
PRSC1
resolver
hgnc
HGNC:9472
resolver
uniprot
O00123
resolver
uniprot
Q53XC6
resolver
uniprot
Q86TV2
resolver
uniprot
Q86TV3
resolver
uniprot
Q96CY7
resolver
uniprot
Q9BTY1
resolver
uniprot_entry
LGMN_HUMAN
resolver
uniprot_entry
Q53XC6_HUMAN
resolver
uniprot_entry
Q96CY7_HUMAN
resolver
uniprot_sec
O00123
resolver
uniprot_sec
Q86TV2
resolver
uniprot_sec
Q86TV3
resolver
uniprot_sec
Q9BTY1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by CST6. {ECO:0000269|PubMed:30425301}.
uniprot
proteins
amino_acid_sequence
MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGDAEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVTHLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASEAEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHRIKLSMDHVCLGHY
uniprot
proteins
ec_number
3.4.22.34
uniprot
proteins
function
FUNCTION: Has a strict specificity for hydrolysis of asparaginyl bonds (PubMed:23776206). Can also cleave aspartyl bonds slowly, especially under acidic conditions (PubMed:23776206). Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (PubMed:9872320). Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol (By similarity). Required for normal lysosomal protein degradation in renal proximal tubules (By similarity). Required for normal degradation of internalized EGFR (By similarity). Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). {ECO:0000250|UniProtKB:O89017, ECO:0000269|PubMed:23776206, ECO:0000269|PubMed:9872320}.
uniprot
proteins
mass_dalton
49411
uniprot
proteins
mutagenesis
MUTAGEN 190; /note="E->K: Increases catalytic activity at pH 5.5."; /evidence="ECO:0000269|PubMed:23776206"; MUTAGEN 323; /note="N->D,Q,S: Loss of autoactivation."; /evidence="ECO:0000269|PubMed:11085925
uniprot
proteins
post_translational_modification
PTM: Activated by autocatalytic processing at pH 4. {ECO:0000269|PubMed:11085925}.
uniprot
proteins
protein_family
Peptidase C13 family
uniprot
proteins
pubmed
11085925
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23776206
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30425301
uniprot
proteins
pubmed
8893817
uniprot
proteins
pubmed
9065484
uniprot
proteins
pubmed
9821970
uniprot
proteins
pubmed
9872320
uniprot
proteins
sequence_length
433
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:9872320}.
uniprot
proteins