Pif1
entrez
208084
canonical
uniprot
Q80SX8
canonical
ensembl
ENSMUSG00000041064
resolver
ensp
ENSMUSP00000049046
resolver
ensp
ENSMUSP00000117494
resolver
ensp
ENSMUSP00000122060
resolver
ensp
ENSMUSP00000339052
resolver
ensp
ENSMUSP00000339055
resolver
enst
ENSMUST00000047099
resolver
enst
ENSMUST00000131483
resolver
enst
ENSMUST00000134538
resolver
genesymbol
Pif1
resolver
genesymbol_syn
PIF1
resolver
uniprot
A0A6Q6QXN1
resolver
uniprot
Q80W44
resolver
uniprot
Q8BIZ3
resolver
uniprot
Q8BJ72
resolver
uniprot_entry
A0A6Q6QXN1_MOUSE
resolver
uniprot_entry
PIF1_MOUSE
resolver
uniprot_sec
Q80W44
resolver
uniprot_sec
Q8BIZ3
resolver
uniprot_sec
Q8BJ72
resolver
amino_acid_sequence
MRSGLCTPAEALEMPSSTEAATDECDDAELRCRVAVEELSPGGQPRKRQALRAAELSLGRNERRELMLRLQAPGPTGRPRCFPLRAVRLFTRFAATGRSTLRLPTDGVPGAGSVQLLLSDCPPERLRRFLRTLRLKLAVAPGPGPASARAQLLGPRPRDFVTISPVQPEELQRAAATKAPDSALEKRPMESQTSTEAPRWPLPVKKLRMPSTKPKLSEEQAAVLRMVLKGQSIFFTGSAGTGKSYLLKHILGSLPPTGTVATASTGVAACHIGGTTLHAFAGIGSGQAPLAQCMALANRPGVRQGWLNCQRLVIDEISMVEADFFDKLEAVARAVRQQKKPFGGIQLIICGDFLQLPPVTKGSQQPQFCFQAKSWRRCVPVILELTEVWRQADQTFISLLQAVRLGRCSDEVTRQLRATAAHKVGRDGIVATRLCTHQDDVALTNEKWLKALPGDVHSFEAIDSDPELSRTLDAQCPVSRVLQLKLGAQVMLVKNLAVSRGLVNGARGVVVGFESEGRGLPRVRFLCGITEVIRTDRWTVQVTGGQYLSRQQLPLQLAWAISIHKSQGMSLDCVEISLGRVFASGQAYVALSRARSLQGLRVLDFDPTVVRCDSRVLHFYATLRQGRGLSLESQDDEEANSDLENMDPNL
uniprot
proteins
ec_number
5.6.2.3
uniprot
proteins
function
FUNCTION: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. {ECO:0000255|HAMAP-Rule:MF_03176}.
uniprot
proteins
mass_dalton
70942
uniprot
proteins
protein_family
Helicase family
uniprot
proteins
protein_family
PIF1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17130244
uniprot
proteins
pubmed
23275553
uniprot
proteins
sequence_length
650
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:17130244}.; SUBCELLULAR LOCATION: [Isoform 3]: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:23275553}.
uniprot
proteins