Psma1
entrez
26440
canonical
uniprot
Q9R1P4
canonical
ensembl
ENSMUSG00000030751
resolver
ensp
ENSMUSP00000033008
resolver
enst
ENSMUST00000033008
resolver
genesymbol
Psma1
resolver
uniprot
Q3TS44
resolver
uniprot_entry
PSA1_MOUSE
resolver
uniprot_entry
Q3TS44_MOUSE
resolver
amino_acid_sequence
MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLDELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLDGLEERPQRKAQPSQAAEEPAEKADEPMEH
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:12874245, ECO:0000269|PubMed:16581775, ECO:0000269|PubMed:19526544, ECO:0000269|PubMed:22341445}.
uniprot
proteins
mass_dalton
29547
uniprot
proteins
post_translational_modification
PTM: C-terminal extension is partially cleaved off by limited proteolysis leading to a conversion of the proteasome from its latent into its active form.
uniprot
proteins
protein_family
Peptidase T1A family
uniprot
proteins
pubmed
10436176
uniprot
proteins
pubmed
10873386
uniprot
proteins
pubmed
12874245
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16317774
uniprot
proteins
pubmed
16581775
uniprot
proteins
pubmed
16857966
uniprot
proteins
pubmed
17521679
uniprot
proteins
pubmed
19526544
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22341445
uniprot
proteins
pubmed
22556278
uniprot
proteins
sequence_length
263
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P25786}. Nucleus {ECO:0000250|UniProtKB:P25786}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000250|UniProtKB:P25786}.
uniprot
proteins