St3gal4
entrez
20443
canonical
uniprot
Q91Y74
canonical
ensembl
ENSMUSG00000032038
resolver
ensp
ENSMUSP00000034537
resolver
ensp
ENSMUSP00000281769
resolver
enst
ENSMUST00000034537
resolver
genesymbol
St3gal4
resolver
genesymbol_syn
Siat4c
resolver
uniprot
P97354
resolver
uniprot
Q61325
resolver
uniprot_entry
SIA4C_MOUSE
resolver
uniprot_sec
P97354
resolver
uniprot_sec
Q61325
resolver
amino_acid_sequence
MTSKSHWKLLALALVLVVVMVWYSISREDRYIEFFYFPISEKKEPCFQGEAERQASKIFGNRSREQPIFLQLKDYFWVKTPSTYELPFGTKGSEDLLLRVLAITSYSIPESIKSLECRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPKIENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQVRILNPFFMEIAADKLLSLPIQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDASNKKQTIHYYEQITLKSMAGSGHNVSQEAIAIKRMLEMGAVKNLTYF
uniprot
proteins
ec_number
2.4.3.2
uniprot
proteins
ec_number
2.4.3.4
uniprot
proteins
ec_number
2.4.3.6
uniprot
proteins
function
FUNCTION: A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (By similarity) (PubMed:12097641). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage (By similarity) (PubMed:9184827). Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (PubMed:12097641). Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation (PubMed:25498912). Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (PubMed:18519646). In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively (By similarity). Metabolizes brain c-series ganglioside GT1c forming GQ1c (By similarity). Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin (By similarity). {ECO:0000250|UniProtKB:P61131, ECO:0000250|UniProtKB:Q11206, ECO:0000269|PubMed:12097641, ECO:0000269|PubMed:18519646, ECO:0000269|PubMed:25498912, ECO:0000269|PubMed:9184827}.
uniprot
proteins
mass_dalton
38058
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation.
uniprot
proteins
protein_family
Glycosyltransferase 29 family
uniprot
proteins
pubmed
11389169
uniprot
proteins
pubmed
12097641
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18519646
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25498912
uniprot
proteins
pubmed
9184827
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..26; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins