Ethe1
entrez
66071
canonical
uniprot
Q9DCM0
canonical
ensembl
ENSMUSG00000064254
resolver
ensp
ENSMUSP00000076433
resolver
ensp
ENSMUSP00000161734
resolver
ensp
ENSMUSP00000161735
resolver
ensp
ENSMUSP00000161737
resolver
enst
ENSMUST00000077191
resolver
genesymbol
Ethe1
resolver
genesymbol_syn
Hsco
resolver
uniprot
Q9ESL5
resolver
uniprot_entry
ETHE1_MOUSE
resolver
uniprot_sec
Q9ESL5
resolver
amino_acid_sequence
MASAVVRVAGRRLSQQSASGAPVLLRQMFEPKSCTYTYLLGDRESREAVLIDPVLETAHRDAQLIKELGLKLLYAVNTHCHADHITGTGVLRSLLPGCQSVISRLSGAQADLHIGEGDSIRFGRFALETRASPGHTPGCVTFVLNDQSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGNCLIYPAHDYHGLTVSTVEEERTLNPRLTLSCEEFIKVMDNLNLPKPQQIDIAVPANMRCGVQTPPS
uniprot
proteins
ec_number
1.13.11.18
uniprot
proteins
function
FUNCTION: First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (By similarity). Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. {ECO:0000250|UniProtKB:O95571, ECO:0000269|PubMed:19136963}.
uniprot
proteins
mass_dalton
27739
uniprot
proteins
protein_family
Glyoxalase II family
uniprot
proteins
protein_family
Metallo-beta-lactamase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19136963
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O95571}. Nucleus {ECO:0000250|UniProtKB:O95571}. Mitochondrion matrix {ECO:0000250|UniProtKB:O95571}.
uniprot
proteins