Synpo2
entrez
499702
canonical
uniprot
D4A702
canonical
ensembl
ENSRNOG00000014867
resolver
ensp
ENSRNOP00000019931
resolver
genesymbol
Synpo2
resolver
uniprot_entry
SYNP2_RAT
resolver
amino_acid_sequence
MGTGDFICISMTGGAPWGFRLQGGKEEKQPLQVAKIRSQSKASDSGLCVGDEVVSINGNPCADLTYPEVIKLMESITDSLHLLIKRPTSGTSEALDSETENTNHQHLPHGGPMESTTLQIQHAAKTQGKDFLLASVQTSAPRTEDQGNAWGYAECTTEDQVSQMPGSQEGHLVEEVILRKKPEAGQPGHVVELQLSLSKERQRCTSDPIVTLLGNEKFKSPDPDWGTQHGRTVHINSIPAPEKADTSLTSGTTVQTSSGRELTVIQGRDPGGTGLPQVEVILDCSDRLKAEECRLQAGRGCVASPVEGGRSEAPPSLVSFAVSSEGTEQGEDQRSGKDQGRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELEREEEEEDQEAGDKDEISDLAFLGTSESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKRLNRGDKMEMLPDTTGKGALMFAKRRERMEQFTAQNEEEKTGGLAGGGSDALQTDGLRTMTSYQRKEESVRMQSSVSESSFQMGRSLGSVPQQNGFSGVSETAGPQRMIPMNRTAKPFLGSVNQTAAPFSPTQSVTSPIPDFPAPPPYSAVSPPPEAFSRGISSPVAGPAQPPPWPQPAPWSQPAFYDSSEQIASRDERIAVPAKRTGILQEAKRRGTTKPMFTFKETKVSPNPELLSLLQNAEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSAKQKTPPPVAPKPAVKTSSSSQPVAPVSPVWSPGVAPAQGPAFSTTNPPNPPQVTAVSSIKIAQPTCPPARPASALNLAGPFKGPQAAVVSHNYTPKPSAPTPLVNAAPAGAGGPSNELPGMSGKGAQLFAKRQSRMEKYVVDSDTVQAHTVRAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAAIKSQPPGAQASKTSKKKGKKPLNTLDVMKHQPYQLNASLFTFQPPDSKDGLPQKSTVKVSSVAPAMKQALPPRQADIGSPTNAKASSVYSVPAYTSQPNFFAEATSPVSASPVPVSVPTSPKQETTSTSYFVAPRPKFSAKKSGVTVQENWRSLSLPGRAAPPIMSAPPWLCQPAYSYSSKPTLEQEKANKRPTPWEAAAKSPLGLVDEAFRPRNIEESIVANVVSAARRKVFAGSQEDWKERLSFVPQTQKTSMSFSERREYNVPSPVNSHVSSHSLYSSQLPYVCYRKESRNDLKAMSMDTRSEYCLPLGGYDYNPHPRGWRHQP
uniprot
proteins
function
FUNCTION: Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines (By similarity). Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (PubMed:23434281). Involved in regulation of cell migration. May be a tumor suppressor (By similarity). {ECO:0000250|UniProtKB:Q91YE8, ECO:0000250|UniProtKB:Q9UMS6, ECO:0000269|PubMed:23434281}.
uniprot
proteins
mass_dalton
136025
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA, and by CaMK2 at multiple sites. Dephosphorylated by calcineurin at Ser-558 and Thr-605; abrogating interaction with YWHAB and impairing nuclear import. {ECO:0000250|UniProtKB:Q91YE8}.
uniprot
proteins
protein_family
Synaptopodin family
uniprot
proteins
pubmed
11673475
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23434281
uniprot
proteins
sequence_length
1262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91YE8}. Cytoplasm {ECO:0000250|UniProtKB:Q91YE8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9UMS6}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11673475}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q9UMS6}. Note=Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. In undifferentiated myoblasts strongly expressed in the nucleus, after induction of myotube differentiation is located to both nucleus and cytoplasm along acting filaments, and in differentiated myotubes is located at the Z lines. Upon stress redistributes from cytoplasm of myoblasts and myotubes to the nucleus. Nuclear import is KPNA2-dependent and promoted by phosphorylation by PKA and/or CaMK2, and inhibition of calcineurin. The nuclear export is XPO1-dependent. Localized in a fiber-like pattern, partly overlapping with filamentous actin (By similarity). {ECO:0000250|UniProtKB:Q91YE8, ECO:0000250|UniProtKB:Q9UMS6}.
uniprot
proteins