Retreg1
entrez
66270
canonical
uniprot
Q8VE91
canonical
ensembl
ENSMUSG00000022270
resolver
ensp
ENSMUSP00000022881
resolver
ensp
ENSMUSP00000106068
resolver
ensp
ENSMUSP00000154070
resolver
ensp
ENSMUSP00000154471
resolver
ensp
ENSMUSP00000154765
resolver
genesymbol
Retreg1
resolver
genesymbol_syn
Fam134b
resolver
uniprot
E9QPM1
resolver
uniprot
Q7TMY5
resolver
uniprot
Q9CUJ4
resolver
uniprot
Q9D8Z5
resolver
uniprot_entry
RETR1_MOUSE
resolver
uniprot_sec
E9QPM1
resolver
uniprot_sec
Q7TMY5
resolver
uniprot_sec
Q9CUJ4
resolver
uniprot_sec
Q9D8Z5
resolver
amino_acid_sequence
MASPAPEEHATQGCPATEEQPPRPGVPGEEAGPEGAGPQVEEAAGRVAAALTWLLGEPVLWLGWRADELLSWKRPLRSLLTFLGANLLFWFLALTPWRVYHLISVMILGRVIMQIIKEMVLSRTRGAQLWRSLTESWEVINSKPDERARLSQCIAESWMNFSMFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYLLLLFAFLCPLFKCNDIGQKIYSKVKSILLKLDFGIGEYINQKKRERSEADKEKSHKDDSELDFSALCPKISLTVAAKELSVSDTDVSEVSWTDNGTFNLSEGYTPQTDTSDDLDRPSEEVFSRDLSDFPSLENGTGTNDEDELSLGLPTELKRKKQQLDSAHRPSKERQSAAGLSLPLKSDQALHLMSNLAGDVITAAMTAAIKDQLEGARQALTQVAPTAGEDTDTEEGDDFELLDQAELDQIESELGLTQDQGAEAQQSKKSSGFLSNLLGGH
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720, PubMed:34338405). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720, PubMed:34338405). Active under basal conditions (By similarity). Required for collagen quality control in a LIR motif-dependent manner (PubMed:34338405). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720). {ECO:0000250|UniProtKB:Q9H6L5, ECO:0000269|PubMed:19838196, ECO:0000269|PubMed:26040720}.
uniprot
proteins
mass_dalton
52967
uniprot
proteins
mutagenesis
MUTAGEN 438..441; /note="FELL->AELA: Abolishes interaction with ATG8 family proteins."; /evidence="ECO:0000269|PubMed:34338405
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-134 by CAMK2B enhances oligomerization and membrane scission and reticulophagy activity. {ECO:0000250|UniProtKB:Q9H6L5}.
uniprot
proteins
protein_family
RETREG family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19838196
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26040720
uniprot
proteins
pubmed
31930741
uniprot
proteins
pubmed
34338405
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:19838196}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9H6L5}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..64; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 76..93; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 99..116; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins