Cacna1a
entrez
12286
canonical
uniprot
P97445
canonical
ensembl
ENSMUSG00000034656
resolver
ensp
ENSMUSP00000112436
resolver
ensp
ENSMUSP00000114055
resolver
ensp
ENSMUSP00000158803
resolver
enst
ENSMUST00000121390
resolver
enst
ENSMUST00000122053
resolver
enst
ENSMUST00000238701
resolver
genesymbol
Cacna1a
resolver
genesymbol_syn
Caca1a
resolver
genesymbol_syn
Cach4
resolver
genesymbol_syn
Cacn3
resolver
genesymbol_syn
Cacnl1a4
resolver
genesymbol_syn
Ccha1a
resolver
uniprot
A0A571BET0
resolver
uniprot
E9Q1R5
resolver
uniprot
Q2TPN3
resolver
uniprot
Q3UHA5
resolver
uniprot
Q3UHN4
resolver
uniprot
Q8R5M6
resolver
uniprot
Q8R5M7
resolver
uniprot_entry
A0A571BET0_MOUSE
resolver
uniprot_entry
CAC1A_MOUSE
resolver
uniprot_entry
E9Q1R5_MOUSE
resolver
uniprot_entry
Q3UHA5_MOUSE
resolver
uniprot_entry
Q3UHN4_MOUSE
resolver
uniprot_entry
Q8R5M6_MOUSE
resolver
uniprot_entry
Q8R5M7_MOUSE
resolver
uniprot_sec
Q2TPN3
resolver
amino_acid_sequence
MARFGDEMPGRYGAGGGGSGPAAGVVVGAAGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDGALRRATLKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPTKSVWEQRTSEMRKQNLLASREALYGDAAERWPTPYARPLRPDVKTHLDRPLVVDPQENRNNNTNKSRAPEALRPTARPRESARDPDARRAWPGSPERAPGREGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDLPLAEDLDNMKNNKLATGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPEHMAVEIPPACPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEADPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFERDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTADCGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQNRTPLMFQRMEPPSPTQEGGPSQNALPSTQLDPGGGLMAHEGGMKESPSWVTQRAQEMFQKTGTWSPERGPPIDMPNSQPNSQSVEMREMGTDGYSDSEHYLPMEGQTRAASMPRLPAENQRRRGRPRGNDLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSKDRDQDRGRPKDRKHRPHHHHHHHHHHPPAPDRDRYAQERPDTGRARAREQRWSRSPSEGREHTTHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPCTPRPLVSYSPAPRRPAARRMAGPAAPPGGSPRGCRRAPRWPAHAPEGPRPRGADYTEPDSPREPPGGAHDPAPRSPRTPRAAGCASPRHGRRLPNGYYAGHGAPRPRTARRGAHDAYSESEDDWC
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Cacna1a are the cause of a delayed-onset, recessive neurological disorder seen in tottering (tg) mutants, resulting in ataxia, motor seizures and behavioral absence seizures resembling petit mal epilepsy (or absence epilepsy) in humans. There are two more alleles, leaner (tg(lA)), that is characterized by severe ataxia and frequent death past weaning, but no motor seizures; and rolling Nagoya (tg(rol)), that presents an intermediary phenotype, the ataxia being somewhat more severe that with tg, but without motors seizures. Selective degeneration of cerebellar Purkinje cells has been shown for all these types of mutants. Selective degeneration of cerebellar Purkinje cells has been shown for all these types of mutants. {ECO:0000269|PubMed:8929530}.
uniprot
proteins
function
FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP). {ECO:0000250|UniProtKB:O00555, ECO:0000250|UniProtKB:P54282}.
uniprot
proteins
mass_dalton
267647
uniprot
proteins
protein_family
CACNA1A subfamily
uniprot
proteins
protein_family
Calcium channel alpha-1 subunit (TC 1.A.1.11) family
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8929530
uniprot
proteins
sequence_length
2368
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O00555}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 101..119; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 139..156; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 169..184; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 193..211; /note="Helical; Name=S4 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 231..250; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 338..362; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 490..509; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 524..543; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 552..570; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 581..599; /note="Helical; Name=S4 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 619..638; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 692..716; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 1191..1214; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1232..1251; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1259..1282; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1294..1311; /note="Helical; Name=S4 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1331..1350; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1438..1462; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1519..1537; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1552..1573; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1581..1600; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1608..1626; /note="Helical; Name=S4 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1646..1665; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1738..1763; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000255
uniprot
proteins