CDCA7L
entrez
55536
canonical
uniprot
Q96GN5
canonical
ensembl
ENSG00000164649
resolver
ensp
ENSP00000348523
resolver
ensp
ENSP00000363045
resolver
ensp
ENSP00000383986
resolver
genesymbol
CDCA7L
resolver
genesymbol_syn
HR1
resolver
genesymbol_syn
JPO2
resolver
genesymbol_syn
R1
resolver
hgnc
HGNC:30777
resolver
uniprot
A4D141
resolver
uniprot
A6NF50
resolver
uniprot
A8K8X5
resolver
uniprot
B3KTR5
resolver
uniprot
B4DUT3
resolver
uniprot
C9K0Y1
resolver
uniprot
Q6PIL4
resolver
uniprot
Q86YT0
resolver
uniprot
Q8IXN5
resolver
uniprot
Q96C70
resolver
uniprot
Q9H9A2
resolver
uniprot
Q9NPV2
resolver
uniprot_entry
A8K8X5_HUMAN
resolver
uniprot_entry
CDA7L_HUMAN
resolver
uniprot_sec
A4D141
resolver
uniprot_sec
A6NF50
resolver
uniprot_sec
B3KTR5
resolver
uniprot_sec
B4DUT3
resolver
uniprot_sec
C9K0Y1
resolver
uniprot_sec
Q6PIL4
resolver
uniprot_sec
Q86YT0
resolver
uniprot_sec
Q8IXN5
resolver
uniprot_sec
Q96C70
resolver
uniprot_sec
Q9H9A2
resolver
uniprot_sec
Q9NPV2
resolver
amino_acid_sequence
MELATRYQIPKEVADIFNAPSDDEEFVGFRDDVPMETLSSEESCDSFDSLESGKQQDVRFHSKYFTEELRRIFIEDTDSETEDFAGFTQSDLNGKTNPEVMVVESDLSDDGKASLVSEEEEDEEEDKATPRRSRSRRSSIGLRVAFQFPTKKLANKPDKNSSSEQLFSSARLQNEKKTILERKKDCRQVIQREDSTSESEDDSRDESQESSDALLKRTMNIKENKAMLAQLLAELNSMPDFFPVRTPTSASRKKTVRRAFSEGQITRRMNPTRSARPPEKFALENFTVSAAKFAEEFYSFRRRKTIGGKCREYRRRHRISSFRPVEDITEEDLENVAITVRDKIYDKVLGNTCHQCRQKTIDTKTVCRNQGCCGVRGQFCGPCLRNRYGEDVRSALLDPDWVCPPCRGICNCSYCRKRDGRCATGILIHLAKFYGYDNVKEYLESLQKELVEDN
uniprot
proteins
function
FUNCTION: Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. {ECO:0000269|PubMed:15654081, ECO:0000269|PubMed:15994933, ECO:0000269|PubMed:16829576}.
uniprot
proteins
mass_dalton
52206
uniprot
proteins
mutagenesis
MUTAGEN 16; /note="I->A: Significant loss of interaction with PSIP1; when associated with A-17. Complete loss of interaction with PSIP1; when associated with A-17, A-72 and A-73."; /evidence="ECO:0000269|PubMed:29997176"; MUTAGEN 17; /note="F->A: Significant loss of interaction with PSIP1; when associated with A-16. Complete loss of interaction with PSIP1; when associated with A-16, A-72 and A-73."; /evidence="ECO:0000269|PubMed:29997176"; MUTAGEN 21; /note="S->D: Phosphomimetic mutant. Increased interaction with PSIP1; when associated with D-77, D-79 and D-81."; /evidence="ECO:0000269|PubMed:29997176"; MUTAGEN 72; /note="I->A: Significant loss of interaction with PSIP1; when associated with A-73. Complete loss of interaction with PSIP1; when associated with A-16, A-17 and A-73."; /evidence="ECO:0000269|PubMed:29997176"; MUTAGEN 73; /note="F->A: Significant loss of interaction with PSIP1; when associated with A-72. Complete loss of interaction with PSIP1; when associated with A-16, A-17 and A-72."; /evidence="ECO:0000269|PubMed:29997176"; MUTAGEN 77; /note="T->D: Phosphomimetic mutant. Increased interaction with PSIP1; when associated with D-21, D-79 and D-81."; /evidence="ECO:0000269|PubMed:29997176"; MUTAGEN 79; /note="S->D: Phosphomimetic mutant. Increased interaction with PSIP1; when associated with D-21, D-77 and D-81."; /evidence="ECO:0000269|PubMed:29997176"; MUTAGEN 81; /note="T->D: Phosphomimetic mutant. Increased interaction with PSIP1; when associated with D-21, D-77 and D-79."; /evidence="ECO:0000269|PubMed:29997176
uniprot
proteins
post_translational_modification
PTM: Phosphorylation increases its interaction with PSIP1. {ECO:0000269|PubMed:29997176}.
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15654081
uniprot
proteins
pubmed
15994933
uniprot
proteins
pubmed
16728402
uniprot
proteins
pubmed
16735438
uniprot
proteins
pubmed
16829576
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25082813
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29961568
uniprot
proteins
pubmed
29997176
uniprot
proteins
sequence_length
454
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
uniprot
proteins