Emc4
entrez
68032
canonical
uniprot
Q9CZX9
canonical
ensembl
ENSMUSG00000027131
resolver
ensp
ENSMUSP00000028551
resolver
ensp
ENSMUSP00000201919
resolver
ensp
ENSMUSP00000340342
resolver
enst
ENSMUST00000028551
resolver
genesymbol
Emc4
resolver
genesymbol_syn
Tmem85
resolver
uniprot
A2AGJ7
resolver
uniprot
Q9D1D9
resolver
uniprot_entry
EMC4_MOUSE
resolver
uniprot_sec
A2AGJ7
resolver
uniprot_sec
Q9D1D9
resolver
amino_acid_sequence
MTTQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLMGLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGLLL
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. {ECO:0000250|UniProtKB:Q5J8M3}.
uniprot
proteins
mass_dalton
20117
uniprot
proteins
protein_family
EMC4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5J8M3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5J8M3}. Note=Could also be a single-pass transmembrane protein with cytosolic N-terminus and lumenal C-terminus. {ECO:0000250|UniProtKB:Q5J8M3}.
uniprot
proteins
transmembrane_region
TRANSMEM 67..87; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q5J8M3"; TRANSMEM 99..120; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q5J8M3"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q5J8M3
uniprot
proteins