SLC7A6
entrez
9057
canonical
uniprot
Q92536
canonical
ensembl
ENSG00000103064
resolver
ensp
ENSP00000219343
resolver
ensp
ENSP00000455064
resolver
ensp
ENSP00000573509
resolver
ensp
ENSP00000573510
resolver
ensp
ENSP00000573511
resolver
ensp
ENSP00000598705
resolver
ensp
ENSP00000598706
resolver
ensp
ENSP00000598707
resolver
ensp
ENSP00000598708
resolver
ensp
ENSP00000633326
resolver
ensp
ENSP00000633328
resolver
ensp
ENSP00000633329
resolver
enst
ENST00000219343
resolver
enst
ENST00000566454
resolver
enst
ENST00000903450
resolver
enst
ENST00000903451
resolver
enst
ENST00000903452
resolver
enst
ENST00000928646
resolver
enst
ENST00000928647
resolver
enst
ENST00000928648
resolver
enst
ENST00000928649
resolver
enst
ENST00000963267
resolver
enst
ENST00000963269
resolver
enst
ENST00000963270
resolver
genesymbol
SLC7A6
resolver
genesymbol_syn
KIAA0245
resolver
hgnc
HGNC:11064
resolver
uniprot
Q68DS4
resolver
uniprot
Q7L1N3
resolver
uniprot_entry
YLAT2_HUMAN
resolver
uniprot_sec
Q68DS4
resolver
uniprot_sec
Q7L1N3
resolver
activity_regulation
ACTIVITY REGULATION: Arginine transport is strongly inhibited by lysine, glutamate, leucine, glutamine, methionine and histidine, in the presence of Na(+) (PubMed:10903140). Also inhibited by protein kinase C (PKC) and treatment with phorbol-12-myristate-13-acetate (PMA) (PubMed:17329401). {ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:17329401}.
uniprot
proteins
amino_acid_sequence
MEAREPGRPTPTYHLVPNTSQSQVEEDVSSPPQRSSETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIVWAIGGLFSVVGALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIAITFANYIIQPSFPSCDPPYLACRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIAIIVMGLVKLCQGHSEHFQDAFEGSSWDMGNLSLALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTPIPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWKEPKRPRPLKLSVFFPIVFCICSVFLVIVPLFTDTINSLIGIGIALSGVPFYFMGVYLPESRRPLFIRNVLAAITRGTQQLCFCVLTELDVAEEKKDERKTD
uniprot
proteins
function
FUNCTION: Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:10903140, PubMed:11311135, PubMed:14603368, PubMed:15756301, PubMed:16785209, PubMed:17329401, PubMed:19562367, PubMed:31705628, PubMed:9829974). Also exchanges L-arginine with L-lysine in a sodium-independent manner (PubMed:10903140). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10903140). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (PubMed:17197568). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). {ECO:0000250|UniProtKB:D3ZMM8, ECO:0000250|UniProtKB:Q8BGK6, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:19562367, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974}.
uniprot
proteins
mass_dalton
56828
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
protein_family
L-type amino acid transporter (LAT) (TC 2.A.3.8) family
uniprot
proteins
pubmed
10903140
uniprot
proteins
pubmed
11078698
uniprot
proteins
pubmed
11311135
uniprot
proteins
pubmed
11742806
uniprot
proteins
pubmed
14603368
uniprot
proteins
pubmed
15280038
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15756301
uniprot
proteins
pubmed
16785209
uniprot
proteins
pubmed
17197568
uniprot
proteins
pubmed
17329401
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19562367
uniprot
proteins
pubmed
31705628
uniprot
proteins
pubmed
9039502
uniprot
proteins
pubmed
9829974
uniprot
proteins
sequence_length
515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16785209}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..65; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 195..215; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 267..287; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 312..332; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 364..384; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 386..406; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 426..446; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 452..472; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins