Khdrbs1
entrez
20218
canonical
uniprot
Q60749
canonical
ensembl
ENSMUSG00000028790
resolver
ensp
ENSMUSP00000066516
resolver
ensp
ENSMUSP00000115402
resolver
enst
ENSMUST00000066257
resolver
enst
ENSMUST00000129342
resolver
genesymbol
Khdrbs1
resolver
uniprot
A2ACH3
resolver
uniprot
B2KG38
resolver
uniprot
Q3U8T3
resolver
uniprot
Q60735
resolver
uniprot
Q7M4N5
resolver
uniprot
Q99M33
resolver
uniprot_entry
KHDR1_MOUSE
resolver
uniprot_sec
A2ACH3
resolver
uniprot_sec
B2KG38
resolver
uniprot_sec
Q3U8T3
resolver
uniprot_sec
Q60735
resolver
uniprot_sec
Q7M4N5
resolver
uniprot_sec
Q99M33
resolver
amino_acid_sequence
MQRRDDPASRLTRSSGRSCSKDPSGAHPSVRLTPSRPSPLPHRPRGGGGGPRGGARASPATQPPPLLPPSTPGPDATVVGSAPTPLLPPSATAAVKMEPENKYLPELMAEKDSLDPSFTHAMQLLSVEIEKIQKGESKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELSYLNGVPEPSRGRGVSVRGRGAAPPPPPVPRGRGVGPPRGALVRGTPVRGSITRGATVTRGVPPPPTVRGAPTPRARTAGIQRIPLPPTPAPETYEDYGYDDTYAEQSYEGYEGYYSQSQGESEYYDYGHGELQDSYEAYGQDDWNGTRPSLKAPPARPVKGAYREHPYGRY
uniprot
proteins
function
FUNCTION: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. May not be involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species. RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (By similarity). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner. Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (PubMed:12478298, PubMed:22196734, PubMed:24469635). {ECO:0000250|UniProtKB:O75525, ECO:0000269|PubMed:12478298, ECO:0000269|PubMed:12496368, ECO:0000269|PubMed:22196734, ECO:0000269|PubMed:24469635, ECO:0000269|PubMed:7512695, ECO:0000269|PubMed:9315629}.
uniprot
proteins
mass_dalton
48371
uniprot
proteins
mutagenesis
MUTAGEN 58; /note="S->A: Abolishes phosphorylation, abolishes CD44 splicing regulation; when associated with A-71 and A-84."; /evidence="ECO:0000269|PubMed:12478298"; MUTAGEN 71; /note="T->A: Abolishes phosphorylation, abolishes CD44 splicing regulation; when associated with A-58 and A-84."; /evidence="ECO:0000269|PubMed:12478298"; MUTAGEN 84; /note="T->A: Abolishes phosphorylation, abolishes CD44 splicing regulation; when associated with A-58 and A-71."; /evidence="ECO:0000269|PubMed:12478298"; MUTAGEN 229; /note="V->F: Abolishes splicing regulation."; /evidence="ECO:0000269|PubMed:23637638
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated by several non-receptor tyrosine kinases including LCK, FYN and JAK3. Also tyrosine phosphorylated by the non-receptor tyrosine kinase SRMS in an EGF-dependent manner (By similarity). Phosphorylation by PTK6 negatively regulates its RNA binding ability. Phosphorylation by PTK6 at Tyr-440 dictates the nuclear localization of KHDRBS1. Phosphorylation by MAPK1 at Ser-58, Thr-71 and Thr-84 regulates CD44 alternative splicing by promoting CD44 exon v5 inclusion. {ECO:0000250|UniProtKB:Q07666, ECO:0000269|PubMed:12478298, ECO:0000269|PubMed:7512695}.; PTM: Acetylated. Positively correlates with ability to bind RNA. Deacetylated by HDAC6; this regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons. {ECO:0000250|UniProtKB:Q07666}.; PTM: Arginine methylation is required for nuclear localization. Inhibits interaction with Src-like SH3 domains, but not interaction with WW domains of WBP4/FBP21 and FNBP4/FBP30 (By similarity). {ECO:0000250|UniProtKB:Q07666}.
uniprot
proteins
protein_family
KHDRBS family
uniprot
proteins
pubmed
10077576
uniprot
proteins
pubmed
12478298
uniprot
proteins
pubmed
12496368
uniprot
proteins
pubmed
12529443
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19457263
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22196734
uniprot
proteins
pubmed
23637638
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24469635
uniprot
proteins
pubmed
7512695
uniprot
proteins
pubmed
7541765
uniprot
proteins
pubmed
7799925
uniprot
proteins
pubmed
9315629
uniprot
proteins
sequence_length
443
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12496368}. Cytoplasm {ECO:0000250|UniProtKB:Q07666}. Membrane {ECO:0000269|PubMed:12496368}. Note=Predominantly located in the nucleus but also located partially in the cytoplasm. {ECO:0000250|UniProtKB:Q07666}.
uniprot
proteins