Slc19a3
entrez
80721
canonical
uniprot
Q99PL8
canonical
ensembl
ENSMUSG00000038496
resolver
ensp
ENSMUSP00000041683
resolver
ensp
ENSMUSP00000126646
resolver
ensp
ENSMUSP00000215244
resolver
ensp
ENSMUSP00000215246
resolver
ensp
ENSMUSP00000215247
resolver
ensp
ENSMUSP00000215249
resolver
enst
ENSMUST00000045560
resolver
enst
ENSMUST00000164473
resolver
genesymbol
Slc19a3
resolver
uniprot
Q32MF5
resolver
uniprot_entry
S19A3_MOUSE
resolver
uniprot_sec
Q32MF5
resolver
amino_acid_sequence
MDSSCRTPPSNSWVYPTVILCLFGFFSMFRPSEAFLIPFLSEPSKNLTSPEMTNEILPVWTYSYLATLPPVFVLTDYLRYKPVIMLHVVAFATSYLFLLFGQGVMLMQTAEFFFGVVSATEIAYFAYIYSMVSPEHYQKVSSYCRSITLVAYTAGSVLAQLLVSLTNLPYSSLFYISLACVSVAFFFSLFLPMPKKSMFFHAKSDRDDCPKPLEQCTVPKEAQSNRTHSELFANSKNLEDREMSNPDPENSALRHFAHWFQDLKECYSSKHLVYWSLWWAFATAGYNQILNYVQVLWEHKAPSQDSSIYNGAVEAIATFGGALASFSVGYLKVNWDLLGELGLAVFSAVIAGSLFLMNYSRSIWVCYAGYLLVKSSYSFLITIAVFQIAVNLSLERYALVFGIDTFIALVIQTIMTMIVVDQRGLQLPVTTQFLVYGSYFAVIAGVFLMRSIYILCSAKCRKEVQNLATTRSPNEPHPQEPSNVSTKF
uniprot
proteins
function
FUNCTION: High-affinity transporter for the intake of thiamine (PubMed:22194418, PubMed:35512554, PubMed:35724964). Unlike the human ortholog, lacks H(+)-dependent pyridoxine transport activity due to an absence of seven critical amino-acids required for pyridoxine transport (PubMed:35512554, PubMed:35724964). {ECO:0000269|PubMed:22194418, ECO:0000269|PubMed:35512554, ECO:0000269|PubMed:35724964}.
uniprot
proteins
mass_dalton
55073
uniprot
proteins
mutagenesis
MUTAGEN 87; /note="H->Q: Can mediate pyridoxine transport; when associated with G-88; I-92; T-94; W-95; S-169 and N-174."; /evidence="ECO:0000269|PubMed:35724964"; MUTAGEN 88; /note="V->G: Can mediate pyridoxine transport; when associated with Q-87; I-92; T-94; W-95; S-169 and N-174."; /evidence="ECO:0000269|PubMed:35724964"; MUTAGEN 92; /note="A->I: Can mediate pyridoxine transport; when associated with Q-87; G-88; T-94; W-95; S-169 and N-174."; /evidence="ECO:0000269|PubMed:35724964"; MUTAGEN 94; /note="S->T: Can mediate pyridoxine transport; when associated with Q-87; G-88; I-92; W-95; S-169 and N-174."; /evidence="ECO:0000269|PubMed:35724964"; MUTAGEN 95; /note="Y->W: Can mediate pyridoxine transport; when associated with Q-87; G-88; I-92; T-94; S-169 and N-174."; /evidence="ECO:0000269|PubMed:35724964"; MUTAGEN 169; /note="P->S: Can mediate pyridoxine transport; when associated with Q-87; G-88; I-92; T-94; W-95 and N-174."; /evidence="ECO:0000269|PubMed:35724964"; MUTAGEN 174; /note="F->N: Can mediate pyridoxine transport; when associated with Q-87; G-88; I-92; T-94; W-95 and S-169."; /evidence="ECO:0000269|PubMed:35724964
uniprot
proteins
protein_family
Reduced folate carrier (RFC) transporter (TC 2.A.48) family
uniprot
proteins
pubmed
11136550
uniprot
proteins
pubmed
14770311
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22194418
uniprot
proteins
pubmed
35512554
uniprot
proteins
pubmed
35724964
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 55..75; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 83..103; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 336..356; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 370..390; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 400..420; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 429..449; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins