Cox5a
entrez
252934
canonical
uniprot
P11240
canonical
ensembl
ENSRNOG00000018816
resolver
ensembl
ENSRNOG00055004201
resolver
ensembl
ENSRNOG00060002533
resolver
ensp
ENSRNOP00000097463
resolver
ensp
ENSRNOP00055005129
resolver
ensp
ENSRNOP00060002895
resolver
enst
ENSRNOT00000101188
resolver
enst
ENSRNOT00055006718
resolver
enst
ENSRNOT00060004071
resolver
genesymbol
Cox5a
resolver
uniprot_entry
COX5A_RAT
resolver
amino_acid_sequence
MLAAALRRCTAAAAARGLLHPVSAPSPAAAVCSIRCYSHGSHETDEEFDARWVTYFNKPDIDAWELRKGMNTLVGYDLVPEPKIIDAALRACRRLNDFASAVRILEVVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKV
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00427}.
uniprot
proteins
mass_dalton
16130
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P00427}.
uniprot
proteins
post_translational_modification
PTM: In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1. {ECO:0000250|UniProtKB:P20674}.
uniprot
proteins
protein_family
Cytochrome c oxidase subunit 5A family
uniprot
proteins
pubmed
20966424
uniprot
proteins
pubmed
2544858
uniprot
proteins
pubmed
7601105
uniprot
proteins
sequence_length
146
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00426}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00426}; Matrix side {ECO:0000250|UniProtKB:P00426}.
uniprot
proteins