STK25
entrez
10494
canonical
uniprot
O00506
canonical
ensembl
ENSG00000115694
resolver
ensp
ENSP00000325748
resolver
ensp
ENSP00000384162
resolver
ensp
ENSP00000384444
resolver
ensp
ENSP00000385541
resolver
ensp
ENSP00000385687
resolver
ensp
ENSP00000444886
resolver
ensp
ENSP00000446008
resolver
ensp
ENSP00000687458
resolver
ensp
ENSP00000687473
resolver
genesymbol
STK25
resolver
genesymbol_syn
SOK1
resolver
genesymbol_syn
YSK1
resolver
hgnc
HGNC:11404
resolver
uniprot
A0A024R4B2
resolver
uniprot
A0A0S2Z4Y2
resolver
uniprot
A0A0S2Z4Y9
resolver
uniprot
A8K6Z3
resolver
uniprot
A8K7D2
resolver
uniprot
B3KRS6
resolver
uniprot
B4DMA5
resolver
uniprot
B4DVS7
resolver
uniprot
B4E185
resolver
uniprot
B7Z9K1
resolver
uniprot
Q15522
resolver
uniprot
Q5BJF1
resolver
uniprot
Q96BA2
resolver
uniprot_entry
A0A024R4B2_HUMAN
resolver
uniprot_entry
A0A0S2Z4Y2_HUMAN
resolver
uniprot_entry
B3KRS6_HUMAN
resolver
uniprot_entry
B4DMA5_HUMAN
resolver
uniprot_entry
B4DVS7_HUMAN
resolver
uniprot_entry
B4E185_HUMAN
resolver
uniprot_entry
Q96BA2_HUMAN
resolver
uniprot_entry
STK25_HUMAN
resolver
uniprot_sec
A0A0S2Z4Y9
resolver
uniprot_sec
A8K6Z3
resolver
uniprot_sec
A8K7D2
resolver
uniprot_sec
B7Z9K1
resolver
uniprot_sec
Q15522
resolver
uniprot_sec
Q5BJF1
resolver
activity_regulation
ACTIVITY REGULATION: Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-174, possibly as a consequence of stabilization of dimer formation. The C-terminal non-catalytic region inhibits the kinase activity. {ECO:0000269|PubMed:15037601}.
uniprot
proteins
amino_acid_sequence
MAHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLSTLVRPVFGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFSHNRNHLTSTR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Oxidant stress-activated serine/threonine kinase that plays a role in metabolic homeostasis, neuronal polarization, cell migration, Golgi organization, apoptosis or innate immunity. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). Functions as an inhibitor of the PKA pathway by affecting phosphorylation of the PRKAR1A regulatory subunit, which in turn suppresses the kinase activity of the catalytic subunit (PubMed:35977512). Positively regulates the TLR signaling by directly phosphorylating the transcription factor IRF5 (PubMed:40639948). {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:35977512, ECO:0000269|PubMed:40639948}.
uniprot
proteins
mass_dalton
48112
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="K->R: Complete loss of kinase activity; when associated with A-174."; /evidence="ECO:0000269|PubMed:35977512"; MUTAGEN 49; /note="K->R: Loss of kinase activity and autophosphorylation."; /evidence="ECO:0000269|PubMed:15037601"; MUTAGEN 158; /note="D->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15037601"; MUTAGEN 174; /note="T->A: Complete loss of kinase activity; when associated with R-49."; /evidence="ECO:0000269|PubMed:35977512
uniprot
proteins
post_translational_modification
PTM: Undergoes autophosphorylation in response to multiple TLR ligands. {ECO:0000269|PubMed:40639948}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15037601
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18782753
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
34634521
uniprot
proteins
pubmed
35977512
uniprot
proteins
pubmed
40639948
uniprot
proteins
pubmed
8887545
uniprot
proteins
pubmed
9160885
uniprot
proteins
sequence_length
426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15037601}. Golgi apparatus {ECO:0000269|PubMed:15037601}. Note=Localizes to the Golgi apparatus.
uniprot
proteins