ITPKA
entrez
3706
canonical
uniprot
P23677
canonical
ensembl
ENSG00000137825
resolver
ensp
ENSP00000260386
resolver
enst
ENST00000260386
resolver
genesymbol
ITPKA
resolver
hgnc
HGNC:6178
resolver
uniprot
Q8TAN3
resolver
uniprot_entry
IP3KA_HUMAN
resolver
uniprot_sec
Q8TAN3
resolver
activity_regulation
ACTIVITY REGULATION: Activated by calcium/calmodulin. {ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1847047}.
uniprot
proteins
amino_acid_sequence
MTLPGGPTGMARPGGARPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAKRRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSPGPPERERDCLPAAGSSHLQQPRRLSTSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDVGQKNHWQKIRTMVNLPVISPFKKRYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER
uniprot
proteins
ec_number
2.7.1.127
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:15350214, ECO:0000269|PubMed:1847047}.
uniprot
proteins
mass_dalton
51009
uniprot
proteins
mutagenesis
MUTAGEN 188; /note="W->A: Decreases to 44% of kinase activity."; /evidence="ECO:0000269|PubMed:15350214"; MUTAGEN 199; /note="K->A: Decreases to 80% of kinase activity."; /evidence="ECO:0000269|PubMed:15350214"; MUTAGEN 262; /note="D->A,N: Decreases to 12% of kinase activity."; /evidence="ECO:0000269|PubMed:15350214"; MUTAGEN 264; /note="K->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:12747803"; MUTAGEN 319; /note="R->D,A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15350214"; MUTAGEN 416; /note="D->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15350214
uniprot
proteins
protein_family
Inositol phosphokinase (IPK) family
uniprot
proteins
pubmed
12747803
uniprot
proteins
pubmed
15350214
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1847047
uniprot
proteins
pubmed
2175886
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12747803}.
uniprot
proteins