Nrif1
entrez
65020
canonical
uniprot
Q923B3
canonical
ensembl
ENSMUSG00000058638
resolver
ensp
ENSMUSP00000004614
resolver
ensp
ENSMUSP00000132060
resolver
ensp
ENSMUSP00000320350
resolver
enst
ENSMUST00000004614
resolver
enst
ENSMUST00000168247
resolver
genesymbol
Nrif1
resolver
genesymbol
Zfp110
resolver
genesymbol_syn
Nrif
resolver
genesymbol_syn
Zfp110
resolver
uniprot
A0A0R4J249
resolver
uniprot
Q8BS00
resolver
uniprot
Q9D6I6
resolver
uniprot
Q9QZ07
resolver
uniprot_entry
A0A0R4J249_MOUSE
resolver
uniprot_entry
NRIF1_MOUSE
resolver
uniprot_sec
Q8BS00
resolver
uniprot_sec
Q9D6I6
resolver
uniprot_sec
Q9QZ07
resolver
amino_acid_sequence
MASTLPTTWPHESVKFEDVSLTFTEEEWAQLDFQQKCLYREIMMENYSNMISVEHHFSKPNVISQLEKAEDCWPMQREIPQDTLPECSWPSPDPGMNSFPSKSPLMKIEVVEVLTLNKDVAGPRNALIQSLYPEDLNPGNLKPAQQPSKRLTDTEASRQKFRHFQYEESAGPQKAMSQLRKLCHQWLQPNTRSKKQILELLVLEQFLNALPEKFRVWVESQHPEDCKAVVALLENMTSVSKDDASLACSSEATDQLKEKRKGVATLPVTFAAEVPAEEPVTFQDVAVDFNEEEWRLLGPTQKTEYHDVMLETLGNLVSVGWEPTLGNRELTPDSPIPVVKPIHDPNTNDLSRNGTQSTVFESILEDGVKEMHSIESNQVGNLQEKGHPQKKFSESSKSQDQTSRHKSQGSLNEVLPRKYVKVKQKGTGKRKGRTNTISMTRGLRIRKQQKDSVEWQGRSGSTPVTHGSSIKKQQQGSEQGKPGTSRDPITLTVPAKVYQKATGSEESIFMDSSDAMVPDVPPKIHQKGPEWHKVGESNNSMLQGSSVQNHQMESGAGRASDNSLLTHALPVKSHQKGYKEGNVQGNRNSWKHIKPHQKGSKGERVEELSTSEKHVPYVKNHLKTSERGKDREINASIKCDPYIKTYYRGSDVGRLRRANNCRKAFSLHAQQISFIKIHKGSQVCRCSECGKLFRNARYFSVHKKIHTGERPYMCMACGKAFVQSSSLTQHLRIHSGERPFECSECGRTFNDRSAISQHLRTHTGAKPYHCERCGKAFRQSSHLTRHERTHTGERPYVCIKCGKAFTQSSHLIGHQKTHGIKFKKQPKL
uniprot
proteins
function
FUNCTION: Transcription regulator involved in NGFR/p75(NTR)-mediated apoptosis. Essential component of the NGFR/p75(NTR) apoptotic pathway: upon ligand-binding and subsequent cleavage of NGFR/p75(NTR), binds to the intracellular domain (ICD) cleavage product of NGFR/p75(NTR), translocates to the nucleus and induces apoptosis, possibly by regulating expression of key regulators of apoptosis. Induces NGFR/p75(NTR)-mediated apoptosis in retina and sympathetic neurons. May also regulate expression of neuronal cholesterol biosynthesis genes. Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. {ECO:0000269|PubMed:10545116, ECO:0000269|PubMed:15668238, ECO:0000269|PubMed:16630834, ECO:0000269|PubMed:18677445, ECO:0000269|PubMed:18815271}.
uniprot
proteins
mass_dalton
93650
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="K->R: Abolishes ubiquitination by TRAF6, binding to SQSTM1/p62, translocation to the nucleus and NGFR/p75(NTR)-mediated apoptosis."; /evidence="ECO:0000269|PubMed:16252010
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by TRAF6 at Lys-15 through 'Lys-63'-linked polyubiquitination. 'Lys-63'-linked polyubiquitination occurs in response to NGFR/p75(NTR) cleavage by gamma-secretase and promotes binding with the ICD cleavage product of NGFR/p75(NTR), followed by translocation into the nucleus and subsequent apoptosis. {ECO:0000269|PubMed:16252010, ECO:0000269|PubMed:16630834}.
uniprot
proteins
protein_family
Krueppel C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
10545116
uniprot
proteins
pubmed
11750124
uniprot
proteins
pubmed
14960584
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15668238
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16252010
uniprot
proteins
pubmed
16630834
uniprot
proteins
pubmed
18677445
uniprot
proteins
pubmed
18815271
uniprot
proteins
sequence_length
828
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocates into the nucleus following binding to TRAF6 and subsequent ubiquitination at Lys-15.
uniprot
proteins