Pecam1
entrez
18613
canonical
uniprot
Q08481
canonical
ensembl
ENSMUSG00000020717
resolver
ensp
ENSMUSP00000079664
resolver
ensp
ENSMUSP00000099358
resolver
ensp
ENSMUSP00000102408
resolver
ensp
ENSMUSP00000138959
resolver
genesymbol
Pecam1
resolver
genesymbol_syn
Pecam
resolver
genesymbol_syn
Pecam-1
resolver
uniprot
B1ARB1
resolver
uniprot
B1ARB2
resolver
uniprot
Q3TES6
resolver
uniprot
Q8CAW4
resolver
uniprot
Q922E0
resolver
uniprot_entry
PECA1_MOUSE
resolver
uniprot_entry
Q8CAW4_MOUSE
resolver
uniprot_sec
B1ARB1
resolver
uniprot_sec
B1ARB2
resolver
uniprot_sec
Q3TES6
resolver
uniprot_sec
Q922E0
resolver
amino_acid_sequence
MLLALGLTLVLYASLQAEENSFTINSIHMESLPSWEVMNGQQLTLECLVDISTTSKSRSQHRVLFYKDDAMVYNVTSREHTESYVIPQARVFHSGKYKCTVMLNNKEKTTIEYEVKVHGVSKPKVTLDKKEVTEGGVVTVNCSLQEEKPPIFFKIEKLEVGTKFVKRRIDKTSNENFVLMEFPIEAQDHVLVFRCQAGILSGFKLQESEPIRSEYVTVQESFSTPKFEIKPPGMIIEGDQLHIRCIVQVTHLVQEFTEIIIQKDKAIVATSKQSSEAVYSVMAMVEYSGHYTCKVESNRISKASSIMVNITELFPKPKLEFSSSRLDQGELLDLSCSVSGTPVANFTIQKEETVLSQYQNFSKIAEESDSGEYSCTAGIGKVVKRSGLVPIQVCEMLSKPSIFHDAKSEIIKGHAIGISCQSENGTAPITYHLMKAKSDFQTLEVTSNDPATFTDKPTRDMEYQCRADNCHSHPAVFSEILRVRVIAPVDEVVISILSSNEVQSGSEMVLRCSVKEGTSPITFQFYKEKEDRPFHQAVVNDTQAFWHNKQASKKQEGQYYCTASNRASSMRTSPRSSTLAVRVFLAPWKKGLIAVVVIGVVIATLIVAAKCYFLRKAKAKQKPVEMSRPAAPLLNSNSEKISEPSVEANSHYGYDDVSGNDAVKPINQNKDPQNMDVEYTEVEVSSLEPHQALGTRATETVYSEIRKVDPNLMENRYSRTEGSLNGT
uniprot
proteins
function
FUNCTION: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (By similarity). Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (By similarity). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (By similarity). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (By similarity). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (By similarity). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (By similarity). Modulates bradykinin receptor BDKRB2 activation (By similarity). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (By similarity). Induces susceptibility to atherosclerosis (PubMed:19048083). {ECO:0000250|UniProtKB:P16284, ECO:0000269|PubMed:19048083}.
uniprot
proteins
mass_dalton
81263
uniprot
proteins
mutagenesis
MUTAGEN 679; /note="Y->F: Reduces tyrosine phosphorylation by FER by about 60%."; /evidence="ECO:0000269|PubMed:16731527"; MUTAGEN 702; /note="Y->F: Reduces tyrosine phosphorylation by FER by about 60%."; /evidence="ECO:0000269|PubMed:16731527"; MUTAGEN 717; /note="Y->F: No significant effect on phosphorylation by FER."; /evidence="ECO:0000269|PubMed:16731527
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser and Tyr residues by src kinases after cellular activation (PubMed:16731527). Upon activation, phosphorylated on Ser-718 which probably initiates the dissociation of the membrane-interaction segment (residues 698-718) from the cell membrane allowing the sequential phosphorylation of Tyr-702 and Tyr-679 (By similarity). Constitutively phosphorylated on Ser-723 in resting platelets (By similarity). Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation (PubMed:16731527). In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation (By similarity). {ECO:0000250|UniProtKB:P16284, ECO:0000269|PubMed:16731527}.; PTM: Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells and enrichment in membrane rafts. {ECO:0000250|UniProtKB:P16284}.
uniprot
proteins
pubmed
1415479
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16731527
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
18388311
uniprot
proteins
pubmed
19048083
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28179430
uniprot
proteins
pubmed
8516303
uniprot
proteins
sequence_length
727
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P16284}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P16284}. Membrane raft {ECO:0000250|UniProtKB:P16284}. Cell junction {ECO:0000250|UniProtKB:P16284}. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation. {ECO:0000250|UniProtKB:P16284}.
uniprot
proteins
transmembrane_region
TRANSMEM 591..609; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins