Slc38a1
entrez
170567
canonical
uniprot
Q9JM15
canonical
ensembl
ENSRNOG00000005291
resolver
ensembl
ENSRNOG00055012701
resolver
ensembl
ENSRNOG00060006591
resolver
ensembl
ENSRNOG00065019105
resolver
ensp
ENSRNOP00000008138
resolver
ensp
ENSRNOP00055017590
resolver
ensp
ENSRNOP00060008022
resolver
ensp
ENSRNOP00065025633
resolver
enst
ENSRNOT00055021703
resolver
enst
ENSRNOT00060010802
resolver
enst
ENSRNOT00065032119
resolver
genesymbol
Slc38a1
resolver
genesymbol_syn
Ata1
resolver
genesymbol_syn
Glnt
resolver
genesymbol_syn
Sa2
resolver
genesymbol_syn
Sat1
resolver
genesymbol_syn
Snat1
resolver
uniprot_entry
S38A1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by alpha-(methylamino)isobutyric acid (MeAIB) (PubMed:10660562, PubMed:11692272). Inhibited by lithium, potassium, choline ions, N-methylglucamine (PubMed:11692272). The pH dependence has an allosteric effect on the transport (PubMed:11692272). {ECO:0000269|PubMed:10660562, ECO:0000269|PubMed:11692272}.
uniprot
proteins
amino_acid_sequence
MMHFKSGLELTELQNMTVPEDDNVSNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKRKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLILLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKLVIFGATSLQNTGAMLSYLFIVKNELPSAIKSLMGEEETFSAWYVDGRVLVVMVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFQIPCMNGEQNSTVSANVTDACTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYEKVQSDLLHKYQSTGDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFHLCRHVLVTIILLVIINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITNQDGDKNTQRIWAALFLALGVLFSLISIPLVIYDWACSSSNGEGH
uniprot
proteins
function
FUNCTION: Symporter that cotransports short-chain neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10660562, PubMed:11692272, PubMed:11756489, PubMed:12684517). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:11692272, PubMed:11756489, PubMed:12684517). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (PubMed:10660562, PubMed:11756489). May also contributes to amino acid transport in placental trophoblast (By similarity). Regulates synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q8K2P7, ECO:0000250|UniProtKB:Q9H2H9, ECO:0000269|PubMed:10660562, ECO:0000269|PubMed:11692272, ECO:0000269|PubMed:11756489, ECO:0000269|PubMed:12684517}.
uniprot
proteins
mass_dalton
53846
uniprot
proteins
post_translational_modification
PTM: N-glycosylation plays an important role in the L-glutamine transport. {ECO:0000250|UniProtKB:Q8K2P7}.
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
pubmed
10660562
uniprot
proteins
pubmed
11692272
uniprot
proteins
pubmed
11756489
uniprot
proteins
pubmed
12684517
uniprot
proteins
pubmed
12855186
uniprot
proteins
pubmed
15054072
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16023720
uniprot
proteins
pubmed
17323379
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
485
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10660562, ECO:0000269|PubMed:12684517, ECO:0000269|PubMed:15054072}; Multi-pass membrane protein {ECO:0000305|PubMed:10660562}. Note=Restricted to the somatodendritic compartment of neurons (Probable). Found in the cellular processes of neurons in the developing brain. {ECO:0000305|PubMed:12684517}.
uniprot
proteins
transmembrane_region
TRANSMEM 75..97; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 149..169; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 189..211; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 274..294; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 349..369; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 392..412; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 415..435; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 451..471; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins