Q67EQ0
uniprot
Q67EQ0
canonical
amino_acid_sequence
MASEITYAEVRIKNESNSSVTYSGSPAAPREKPTRHLSKPGSLLVPFTSLMVLLLLLAITFLVAFIIYFQKYSQFLEEKKAIKGITHKELNCIKNVLLMEEKSWSCCPKNWKPFGSHCYWVTKHTSTYSKASWSESEKNCFSMGAHLLVIHSKEEQDFITGILNRDAAYFIGLWDSGHRQWQWVSQTPYNASATFWHKGEPSSDDEKCVIINHLNSGWGWNDIPCSGKQQSVCQMKKIQL
uniprot
proteins
function
FUNCTION: C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. {ECO:0000250|UniProtKB:Q9UMR7}.
uniprot
proteins
mass_dalton
27404
uniprot
proteins
pubmed
15368084
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}; Extracellular side {ECO:0000250|UniProtKB:Q9UMR7}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins