HPGD
entrez
3248
canonical
uniprot
P15428
canonical
ensembl
ENSG00000164120
resolver
ensp
ENSP00000296521
resolver
ensp
ENSP00000296522
resolver
ensp
ENSP00000398720
resolver
ensp
ENSP00000420892
resolver
ensp
ENSP00000422418
resolver
ensp
ENSP00000438017
resolver
ensp
ENSP00000443644
resolver
enst
ENST00000504433
resolver
genesymbol
HPGD
resolver
genesymbol_syn
PGDH1
resolver
genesymbol_syn
SDR36C1
resolver
hgnc
HGNC:5154
resolver
uniprot
B4DTA4
resolver
uniprot
B4DU74
resolver
uniprot
B4DV57
resolver
uniprot
D3DP43
resolver
uniprot
E7EV11
resolver
uniprot
E9PBZ2
resolver
uniprot
O00749
resolver
uniprot
Q06F08
resolver
uniprot
Q12998
resolver
uniprot_entry
E9PBZ2_HUMAN
resolver
uniprot_entry
PGDH_HUMAN
resolver
uniprot_sec
B4DTA4
resolver
uniprot_sec
B4DU74
resolver
uniprot_sec
B4DV57
resolver
uniprot_sec
D3DP43
resolver
uniprot_sec
E7EV11
resolver
uniprot_sec
O00749
resolver
uniprot_sec
Q06F08
resolver
uniprot_sec
Q12998
resolver
amino_acid_sequence
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
uniprot
proteins
disease_involvement
DISEASE: Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 (PHOAR1) [MIM:259100]: A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. {ECO:0000269|PubMed:18500342}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Cranioosteoarthropathy (COA) [MIM:259100]: A form of osteoarthropathy characterized by swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature. {ECO:0000269|PubMed:18500342}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Digital clubbing, isolated congenital (DIGC) [MIM:119900]: A rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved. {ECO:0000269|PubMed:18805827}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
ec_number
1.1.1.141
uniprot
proteins
ec_number
1.1.1.232
uniprot
proteins
function
FUNCTION: Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (PubMed:10837478, PubMed:16757471, PubMed:16828555, PubMed:21916491, PubMed:25586183, PubMed:8086429). Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression (PubMed:15574495, PubMed:25586183). Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (PubMed:16757471, PubMed:22844113). {ECO:0000269|PubMed:10837478, ECO:0000269|PubMed:15574495, ECO:0000269|PubMed:16757471, ECO:0000269|PubMed:16828555, ECO:0000269|PubMed:21916491, ECO:0000269|PubMed:22844113, ECO:0000269|PubMed:25586183, ECO:0000269|PubMed:8086429}.
uniprot
proteins
mass_dalton
28977
uniprot
proteins
mutagenesis
MUTAGEN 148; /note="Q->A: Loss of activity."; /evidence="ECO:0000269|PubMed:16828555"; MUTAGEN 148; /note="Q->E,H,N: Reduced affinity for NAD and prostaglandin E2."; /evidence="ECO:0000269|PubMed:16828555"; MUTAGEN 151; /note="Y->A: Loss of activity."; /evidence="ECO:0000269|PubMed:2025296"; MUTAGEN 151; /note="Y->F: Loss 15-hydroxyprostaglandin dehydrogenase activity."; /evidence="ECO:0000269|PubMed:8086429"; MUTAGEN 155; /note="K->Q: Loss 15-hydroxyprostaglandin dehydrogenase activity."; /evidence="ECO:0000269|PubMed:8086429
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
10837478
uniprot
proteins
pubmed
12788907
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15044627
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15574495
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16757471
uniprot
proteins
pubmed
16828555
uniprot
proteins
pubmed
1697582
uniprot
proteins
pubmed
18500342
uniprot
proteins
pubmed
18805827
uniprot
proteins
pubmed
2025296
uniprot
proteins
pubmed
21072165
uniprot
proteins
pubmed
21916491
uniprot
proteins
pubmed
22844113
uniprot
proteins
pubmed
2337593
uniprot
proteins
pubmed
25586183
uniprot
proteins
pubmed
7557451
uniprot
proteins
pubmed
8086429
uniprot
proteins
pubmed
8482380
uniprot
proteins
pubmed
9099873
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins