Trim13
entrez
364398
canonical
uniprot
Q5M7V1
canonical
ensembl
ENSRNOG00000009075
resolver
ensembl
ENSRNOG00055012921
resolver
ensembl
ENSRNOG00060017171
resolver
ensembl
ENSRNOG00065030760
resolver
ensp
ENSRNOP00000012035
resolver
ensp
ENSRNOP00000078168
resolver
ensp
ENSRNOP00000080518
resolver
ensp
ENSRNOP00000086916
resolver
ensp
ENSRNOP00000092048
resolver
ensp
ENSRNOP00000096302
resolver
ensp
ENSRNOP00000099165
resolver
ensp
ENSRNOP00000108511
resolver
ensp
ENSRNOP00000110005
resolver
ensp
ENSRNOP00000110201
resolver
ensp
ENSRNOP00055017967
resolver
ensp
ENSRNOP00055017974
resolver
ensp
ENSRNOP00055017976
resolver
ensp
ENSRNOP00060023573
resolver
ensp
ENSRNOP00060023606
resolver
ensp
ENSRNOP00060023611
resolver
ensp
ENSRNOP00065043533
resolver
ensp
ENSRNOP00065043543
resolver
ensp
ENSRNOP00065043556
resolver
enst
ENSRNOT00000012035
resolver
enst
ENSRNOT00000107093
resolver
enst
ENSRNOT00000109510
resolver
enst
ENSRNOT00000110181
resolver
enst
ENSRNOT00000112782
resolver
enst
ENSRNOT00000116555
resolver
enst
ENSRNOT00000122923
resolver
enst
ENSRNOT00000143561
resolver
enst
ENSRNOT00000148787
resolver
enst
ENSRNOT00000167033
resolver
enst
ENSRNOT00055022126
resolver
enst
ENSRNOT00055022133
resolver
enst
ENSRNOT00055022135
resolver
enst
ENSRNOT00060029309
resolver
enst
ENSRNOT00060029350
resolver
enst
ENSRNOT00060029358
resolver
enst
ENSRNOT00065053006
resolver
enst
ENSRNOT00065053016
resolver
enst
ENSRNOT00065053030
resolver
genesymbol
Trim13
resolver
genesymbol_syn
Rfp2
resolver
uniprot
A0A8L2UIK6
resolver
uniprot_entry
A0A8L2UIK6_RAT
resolver
uniprot_entry
TRI13_RAT
resolver
amino_acid_sequence
MELLEEDLTCPICCSLFDDPRVLPCSHNFCKKCLEGLLEGNVRNSLWRPSPFKCPTCRKETSATGVNSLQVNYSLKGIVEKYNKIKISPKMPVCKEHLGQPLNIFCVTDMQLICGVCATRGSHTKHVFSSIEDAYTQERDAFEFLFQSFETWRRGDALSRLDTLETNKRKSLQLLTKDSDKVKEFFEKLQHTLDQKKNEILSDFETMKLAVMQTYDPEINKLNSILQEQRMAFNIAEAFKDVSEPIIFLQQMQEFREKIKVIKETPLPPSNLPTSPLMKNFDTSQWEDIKLVDVDKLSLPQDTGVLTSRSPWHPCLLLMAVVLLGLLVFFGPTVFLEWSPLEELATWKDCLSSFNSYLTKSADFVEQSVFYWEQMTDGLFVFSERVKNVSLVALNNVAEFVCKYKLL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation. Participates as well in T-cell receptor-mediated NF-kappa-B activation. In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B. {ECO:0000250|UniProtKB:O60858}.
uniprot
proteins
mass_dalton
46815
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:O60858}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated; requires the RING-type zinc finger. Auto-polyubiquitination leads to proteasomal degradation. {ECO:0000250|UniProtKB:O60858}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O60858}; Single-pass membrane protein {ECO:0000250|UniProtKB:O60858}. Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum. {ECO:0000250|UniProtKB:O60858}.
uniprot
proteins
transmembrane_region
TRANSMEM 316..336; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins