Nfkbib
entrez
18036
canonical
uniprot
Q60778
canonical
ensembl
ENSMUSG00000030595
resolver
ensp
ENSMUSP00000032815
resolver
ensp
ENSMUSP00000083012
resolver
enst
ENSMUST00000032815
resolver
enst
ENSMUST00000085851
resolver
genesymbol
Nfkbib
resolver
genesymbol_syn
Ikbb
resolver
uniprot
Q564F1
resolver
uniprot
Q9D6L5
resolver
uniprot_entry
IKBB_MOUSE
resolver
uniprot_sec
Q564F1
resolver
uniprot_sec
Q9D6L5
resolver
amino_acid_sequence
MAGVACLGKTADADEWCDSGLGSLGPDAAAPGGPGLGAELGPELSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYLDLQNDLGQTALHLAAILGEASTVEKLYAAGAGVLVAERGGHTALHLACRVRAHTCACVLLQPRPSHPRDASDTYLTQSQDCTPDTSHAPAAVDSQPNPENEEEPRDEDWRLQLEAENYDGHTPLHVAVIHKDAEMVRLLRDAGADLNKPEPTCGRTPLHLAVEAQAASVLELLLKAGADPTARMYGGRTPLGSALLRPNPILARLLRAHGAPEPEDEDDKLSPCSSSGSDSDSDNRDEGDEYDDIVVHSGRSQNRQPPSPASKPLPDDPNPA
uniprot
proteins
function
FUNCTION: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
uniprot
proteins
mass_dalton
37965
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.
uniprot
proteins
protein_family
NF-kappa-B inhibitor family
uniprot
proteins
pubmed
10657303
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7867065
uniprot
proteins
pubmed
8816457
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
uniprot
proteins