PDLIM2
entrez
64236
canonical
uniprot
Q96JY6
canonical
ensembl
ENSG00000120913
resolver
ensp
ENSP00000265810
resolver
ensp
ENSP00000312634
resolver
ensp
ENSP00000386868
resolver
ensp
ENSP00000387084
resolver
genesymbol
PDLIM2
resolver
hgnc
HGNC:13992
resolver
uniprot
D3DSR5
resolver
uniprot
J3KNH4
resolver
uniprot
Q7Z584
resolver
uniprot
Q86WM8
resolver
uniprot
Q8WZ29
resolver
uniprot
Q9H4L9
resolver
uniprot
Q9H7I2
resolver
uniprot_entry
PDLI2_HUMAN
resolver
uniprot_sec
D3DSR5
resolver
uniprot_sec
J3KNH4
resolver
uniprot_sec
Q7Z584
resolver
uniprot_sec
Q86WM8
resolver
uniprot_sec
Q8WZ29
resolver
uniprot_sec
Q9H4L9
resolver
uniprot_sec
Q9H7I2
resolver
amino_acid_sequence
MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQAGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQSSSFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALATPPKLHTCEKCSTSIANQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYSAPATLSSRA
uniprot
proteins
function
FUNCTION: Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}.
uniprot
proteins
mass_dalton
37459
uniprot
proteins
mutagenesis
MUTAGEN 80; /note="L->K: Abolishes cell adhesion to collagen and ability to suppress anchorage independent growth."; /evidence="ECO:0000269|PubMed:15659642"; MUTAGEN 313; /note="C->S: Abolishes ability to suppress anchorage independent growth but not cell adhesion to collagen; when associated with S-316."; /evidence="ECO:0000269|PubMed:15659642"; MUTAGEN 316; /note="C->S: Abolishes ability to suppress anchorage independent growth but not cell adhesion to collagen; when associated with S-313."; /evidence="ECO:0000269|PubMed:15659642
uniprot
proteins
pubmed
11214971
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
15659642
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15659642}. Nucleus {ECO:0000269|PubMed:15659642}. Note=May be partially nuclear.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton. Note=Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus.
uniprot
proteins