CLYBL
entrez
171425
canonical
uniprot
Q8N0X4
canonical
ensembl
ENSG00000125246
resolver
ensp
ENSP00000342991
resolver
ensp
ENSP00000365532
resolver
ensp
ENSP00000365533
resolver
ensp
ENSP00000508871
resolver
ensp
ENSP00000568581
resolver
ensp
ENSP00000568582
resolver
ensp
ENSP00000568587
resolver
ensp
ENSP00000603104
resolver
ensp
ENSP00000613647
resolver
genesymbol
CLYBL
resolver
genesymbol_syn
CLB
resolver
hgnc
HGNC:18355
resolver
uniprot
Q5W0F7
resolver
uniprot
Q8TDH8
resolver
uniprot_entry
CLYBL_HUMAN
resolver
uniprot_sec
Q5W0F7
resolver
uniprot_sec
Q8TDH8
resolver
amino_acid_sequence
MALRLLRRAARGAAAAALLRLKASLAADIPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKNEARLRIVKTLEDIDLGPTEKCVRVNSVSSGLAEEDLETLLQSRVLPSSLMLPKVESPEEIQWFADKFSFHLKGRKLEQPMNLIPFVETAMGLLNFKAVCEETLKVGPQVGLFLDAVVFGGEDFRASIGATSSKETLDILYARQKIVVIAKAFGLQAIDLVYIDFRDGAGLLRQSREGAAMGFTGKQVIHPNQIAVVQEQFSPSPEKIKWAEELIAAFKEHQQLGKGAFTFQGSMIDMPLLKQAQNTVTLATSIKEK
uniprot
proteins
ec_number
2.3.3.-
uniprot
proteins
ec_number
2.3.3.9
uniprot
proteins
ec_number
3.1.2.30
uniprot
proteins
ec_number
4.1.3.25
uniprot
proteins
function
FUNCTION: Mitochondrial enzyme required to detoxify vitamin B12-poisoning metabolites (PubMed:29056341, PubMed:40108300). Acts as a citramalyl-CoA lyase by converting citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway, a pathway required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Also acts as a malyl-CoA thioesterase to detoxify malyl-CoA, a side product of citric acid cycle enzymes, which is toxic for the vitamin B12-dependent enzyme MMUT (PubMed:40108300). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (PubMed:24334609, PubMed:29056341). Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (PubMed:24334609, PubMed:29056341). Also has very weak citramalate synthase activity in vitro (PubMed:24334609, PubMed:29056341). {ECO:0000269|PubMed:24334609, ECO:0000269|PubMed:29056341, ECO:0000269|PubMed:40108300}.
uniprot
proteins
mass_dalton
37359
uniprot
proteins
mutagenesis
MUTAGEN 320; /note="D->A,N: Abolishes citramalyl-CoA lyase activity."; /evidence="ECO:0000269|PubMed:29056341
uniprot
proteins
protein_family
Citrate lyase beta subunit-like subfamily
uniprot
proteins
protein_family
HpcH/HpaI aldolase family
uniprot
proteins
pubmed
11741334
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23754956
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24334609
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29056341
uniprot
proteins
pubmed
40108300
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305|PubMed:24334609}.
uniprot
proteins