Fam111a
entrez
107373
canonical
uniprot
Q9D2L9
canonical
ensembl
ENSMUSG00000024691
resolver
ensp
ENSMUSP00000025595
resolver
ensp
ENSMUSP00000119518
resolver
ensp
ENSMUSP00000123598
resolver
enst
ENSMUST00000025595
resolver
enst
ENSMUST00000144662
resolver
enst
ENSMUST00000151307
resolver
genesymbol
Fam111a
resolver
uniprot
D3YYD2
resolver
uniprot
Q3T9N2
resolver
uniprot
Q3UQF7
resolver
uniprot
Q8BLH2
resolver
uniprot
Q8CI07
resolver
uniprot
Q8VE75
resolver
uniprot
Q9CU11
resolver
uniprot_entry
D3YYD2_MOUSE
resolver
uniprot_entry
F111A_MOUSE
resolver
uniprot_entry
Q3UQF7_MOUSE
resolver
uniprot_sec
Q3T9N2
resolver
uniprot_sec
Q8BLH2
resolver
uniprot_sec
Q8CI07
resolver
uniprot_sec
Q8VE75
resolver
uniprot_sec
Q9CU11
resolver
amino_acid_sequence
MSCKKRKSQISFNPRKNKKIKDYFSQVPKEEQNDPNTVKVDSKKMPRDITNTRDQRPLSPRKTRQDQTPPLNKKITVTLGVNSRKHKNMKYELTCRETSSLYAALNTLSAVREEVESQKGREMLVCGKEGIEGYLNLGMPVCCIPEGSHVVITFCQCKSKTQENKQFFESQDQASTNYVRFCIHAVGSKRKKILKCGELQKEGNKLCVYGFKGETIRDTLRKDGRFCTFIESDDWKLINDLDTIIENTQPVDELEGKLFQVAAELPKNPRVVSVTQNSGSENRNFHKLEEYIVNEYTTLKEEGKKLRAYIKEKSEKRKKKASLFKVHKEHFGKMTRNSTPVKVVKHLSRVSDSVGFLWWNNNGNAGCATCFVFKELYILTCQHVIASIVGEGIDSSEWANIISQCVKVTFDYEELLPTGDKFFMVKPWFEISDKHLDYAVLELKENGQEVPAGLYHRIRPVPHSGLIYIIGHPEGEKKSIDCCTVVPQSSRRKKCQENFQAREEAGFCFSTSFIHMYTQRSFQEMLHNSDVVTYDTSFFGGSSGSPVFDSNGSLVAMHAAGITCTYQAGVSNIIEFGSIMESIDDHMKQDKYKEWYNTISGNVQNVEMLSIDF
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors. Required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis. {ECO:0000250|UniProtKB:Q96PZ2}.
uniprot
proteins
mass_dalton
69949
uniprot
proteins
post_translational_modification
PTM: Autocatalytically cleaved; autocatalytic cleavage takes place in trans. {ECO:0000250|UniProtKB:Q96PZ2}.
uniprot
proteins
protein_family
FAM111 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
613
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96PZ2}. Chromosome {ECO:0000250|UniProtKB:Q96PZ2}. Cytoplasm {ECO:0000250|UniProtKB:Q96PZ2}. Note=Mainly localizes to nucleus: colocalizes with PCNA on replication sites. {ECO:0000250|UniProtKB:Q96PZ2}.
uniprot
proteins