Fundc2
entrez
67391
canonical
uniprot
Q9D6K8
canonical
ensembl
ENSMUSG00000031198
resolver
ensp
ENSMUSP00000033541
resolver
enst
ENSMUST00000033541
resolver
genesymbol
Fundc2
resolver
genesymbol_syn
Hcbp6
resolver
uniprot
Q80VT2
resolver
uniprot
Q80YD9
resolver
uniprot
Q8BSM8
resolver
uniprot
Q9D617
resolver
uniprot_entry
FUND2_MOUSE
resolver
uniprot_sec
Q80VT2
resolver
uniprot_sec
Q80YD9
resolver
uniprot_sec
Q8BSM8
resolver
uniprot_sec
Q9D617
resolver
amino_acid_sequence
MAANSQGNFDGKFEALDLAELTKKQPWWRKLFGQESGPSAEKYSVATQLVIGGVTGWCTGFVFQKVGKLAATAVGGGFFLLQLANHTGYIKVDWQRVEKDMKKAKEQLKIRKNKQIPTEVKSKAEEVVSFVKKNVLVTGGFFGGFLLGMAS
uniprot
proteins
function
FUNCTION: Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (PubMed:29786068, PubMed:30576423). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (By similarity). {ECO:0000250|UniProtKB:Q9BWH2, ECO:0000269|PubMed:29786068, ECO:0000269|PubMed:30576423}.
uniprot
proteins
mass_dalton
16564
uniprot
proteins
protein_family
FUN14 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29786068
uniprot
proteins
pubmed
30576423
uniprot
proteins
sequence_length
151
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9BWH2}; Multi-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000250|UniProtKB:Q9BWH2}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..63; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 70..90; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins