Bex3
entrez
117089
canonical
uniprot
Q6PDU5
canonical
ensembl
ENSRNOG00000028822
resolver
ensembl
ENSRNOG00055025507
resolver
ensembl
ENSRNOG00060022821
resolver
ensembl
ENSRNOG00065006156
resolver
ensp
ENSRNOP00000042696
resolver
genesymbol
Bex3
resolver
genesymbol_syn
Nade
resolver
genesymbol_syn
Ngfrap1
resolver
uniprot
B2GUV1
resolver
uniprot
Q9JIT2
resolver
uniprot_entry
B2GUV1_RAT
resolver
uniprot_entry
BEX3_RAT
resolver
uniprot_sec
Q9JIT2
resolver
amino_acid_sequence
MANIHQENEEMEQPLQNGQEDRPVGGGEGHQPAANNNNHNHNHNHNHNHNHNHHRRGQARRLAPNFRWAIPNRQMNDGLGGDGDDMEMFMEEMREIRRKLRELQLRNCLRILMGELSNHHDHHDEFCLMP
uniprot
proteins
function
FUNCTION: May be a signaling adapter molecule involved in NGFR/p75NTR-mediated apoptosis induced by NGF (PubMed:11124986). Plays a role in zinc-triggered neuronal death (PubMed:11124986). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). {ECO:0000250|UniProtKB:Q9WTZ9, ECO:0000269|PubMed:11124986}.
uniprot
proteins
mass_dalton
15333
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated (PubMed:15958283). Degraded by the proteasome (PubMed:15958283). {ECO:0000269|PubMed:15958283}.
uniprot
proteins
protein_family
BEX family
uniprot
proteins
pubmed
10764727
uniprot
proteins
pubmed
11124986
uniprot
proteins
pubmed
11224788
uniprot
proteins
pubmed
12873743
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15958283
uniprot
proteins
sequence_length
130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9WTZ9}. Cytoplasm, cytosol {ECO:0000269|PubMed:15958283}. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria. {ECO:0000250|UniProtKB:Q9WTZ9}.
uniprot
proteins