Map2k7
entrez
26400
canonical
uniprot
Q8CE90
canonical
ensembl
ENSMUSG00000002948
resolver
ensembl
ENSMUSG00000109061
resolver
ensp
ENSMUSP00000003027
resolver
ensp
ENSMUSP00000054512
resolver
ensp
ENSMUSP00000106622
resolver
ensp
ENSMUSP00000106623
resolver
ensp
ENSMUSP00000106626
resolver
ensp
ENSMUSP00000106627
resolver
genesymbol
Map2k7
resolver
genesymbol_syn
Mkk7
resolver
uniprot
O35406
resolver
uniprot
O35720
resolver
uniprot
O35871
resolver
uniprot
O35872
resolver
uniprot
O54780
resolver
uniprot
O70242
resolver
uniprot
O70243
resolver
uniprot
Q8BSP1
resolver
uniprot
Q9QWG6
resolver
uniprot
Q9R1Z3
resolver
uniprot
Q9R1Z4
resolver
uniprot
Q9R1Z5
resolver
uniprot
Q9R1Z6
resolver
uniprot_entry
MP2K7_MOUSE
resolver
uniprot_sec
O35406
resolver
uniprot_sec
O35720
resolver
uniprot_sec
O35871
resolver
uniprot_sec
O35872
resolver
uniprot_sec
O54780
resolver
uniprot_sec
O70242
resolver
uniprot_sec
O70243
resolver
uniprot_sec
Q8BSP1
resolver
uniprot_sec
Q9QWG6
resolver
uniprot_sec
Q9R1Z3
resolver
uniprot_sec
Q9R1Z4
resolver
uniprot_sec
Q9R1Z5
resolver
uniprot_sec
Q9R1Z6
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK. Isoforms 3 and 4 have lower basal activity but a higher level of inducible activation, than isoforms 2, 6, 7 and 8. {ECO:0000269|PubMed:9891090}.
uniprot
proteins
amino_acid_sequence
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPIIVITLSPAPAPSQRAALQLPLANDGGSRSPSSESSPQHPTPPTRPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKHYEILEVDVASWFKDVMAKTESPRTSGVLSQHHLPFFSTSVTWGAWPLAAQTPFQSGVIRCRGRVPSPRRATGGSGGQPCVCAGGPGPSFTEMGPSPSPMLSNTFFTPDPGACPGASTWGLPRRRLCQLLTTSTPGCC
uniprot
proteins
ec_number
2.7.12.2
uniprot
proteins
function
FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:11390361, ECO:0000269|PubMed:12624093, ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312105, ECO:0000269|PubMed:9384583, ECO:0000269|PubMed:9405446, ECO:0000269|PubMed:9535930, ECO:0000269|PubMed:9891090}.
uniprot
proteins
mass_dalton
59312
uniprot
proteins
post_translational_modification
PTM: Activated by phosphorylation on Ser-287 and Thr-291 by MAP kinase kinase kinases (MAP3Ks). {ECO:0000269|PubMed:9891090}.
uniprot
proteins
protein_family
MAP kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
10629060
uniprot
proteins
pubmed
11390361
uniprot
proteins
pubmed
12624093
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17496909
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
20801953
uniprot
proteins
pubmed
21333379
uniprot
proteins
pubmed
23963642
uniprot
proteins
pubmed
27084103
uniprot
proteins
pubmed
28111074
uniprot
proteins
pubmed
9312105
uniprot
proteins
pubmed
9384583
uniprot
proteins
pubmed
9405446
uniprot
proteins
pubmed
9535930
uniprot
proteins
pubmed
9733513
uniprot
proteins
pubmed
9891090
uniprot
proteins
sequence_length
535
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9891090}. Cytoplasm {ECO:0000269|PubMed:9891090}.
uniprot
proteins