Npy1r
entrez
18166
canonical
uniprot
Q04573
canonical
ensembl
ENSMUSG00000036437
resolver
ensp
ENSMUSP00000045530
resolver
ensp
ENSMUSP00000148417
resolver
ensp
ENSMUSP00000255321
resolver
ensp
ENSMUSP00000255322
resolver
ensp
ENSMUSP00000255327
resolver
ensp
ENSMUSP00000255328
resolver
genesymbol
Npy1r
resolver
uniprot
Q3V1K5
resolver
uniprot
Q61993
resolver
uniprot_entry
NPY1R_MOUSE
resolver
uniprot_entry
Q3V1K5_MOUSE
resolver
uniprot_sec
Q61993
resolver
amino_acid_sequence
MNSTLFSKVENHSIHYNASENSPLLAFENDDCHLPLAVIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAVMCLPFTFVYTLMDHWVFGETMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYIGITVIWVLAVASSLPFVIYQILTDEPFQNVSLAAFKDKYVCFDKFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKIRDSKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKISMNDNEKV
uniprot
proteins
function
FUNCTION: Receptor for neuropeptide Y (NPY) and peptide YY (PYY). Can also bind with high affinity [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form, while having virtually no affinity for pancreatic polypeptide (PP/PPY) at physiological concentrations. NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels. As a receptor for NPY, it is involved in the regulation of eating behavior and NPY-induced stimulation of food intake (PubMed:9623984). Involved in the regulation of colonic antisecretory tone, and colonic contractility (PubMed:21457230). {ECO:0000250|UniProtKB:P25929, ECO:0000269|PubMed:21457230, ECO:0000269|PubMed:9623984}.
uniprot
proteins
mass_dalton
44015
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1468559
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21457230
uniprot
proteins
pubmed
8530415
uniprot
proteins
pubmed
9623984
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P25929}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P25929}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..62; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P25929"; TRANSMEM 76..98; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P25929"; TRANSMEM 110..135; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P25929"; TRANSMEM 154..174; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P25929"; TRANSMEM 208..232; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P25929"; TRANSMEM 262..284; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P25929"; TRANSMEM 299..322; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P25929
uniprot
proteins