Ido2
entrez
209176
canonical
uniprot
Q8R0V5
canonical
ensembl
ENSMUSG00000031549
resolver
ensp
ENSMUSP00000113979
resolver
ensp
ENSMUSP00000356184
resolver
enst
ENSMUST00000121992
resolver
genesymbol
Ido2
resolver
genesymbol_syn
Indol1
resolver
uniprot
A4UHF3
resolver
uniprot
E9QKA9
resolver
uniprot_entry
I23O2_MOUSE
resolver
uniprot_sec
A4UHF3
resolver
uniprot_sec
E9QKA9
resolver
activity_regulation
ACTIVITY REGULATION: Activity is inhibited by D-1MT (1-methyl-D-tryptophan) and MTH-trp (methylthiohydantoin-DL-tryptophan) but not L-1MT (1-methyl-L-tryptophan). {ECO:0000269|PubMed:17499941}.
uniprot
proteins
amino_acid_sequence
MEPQSQSMTLEVPLSLGRYHISEEYGFLLPNPLEALPDHYKPWMEIALRLPHLIENRQLRAHVYRMPLLDCRFLKSYREQRLAHMALAAITMGFVWQEGEGQPQKVLPRSLAIPFVEVSRNLGLPPILVHSDLVLTNWTKRNPEGPLEISNLETIISFPGGESLRGFILVTVLVEKAAVPGLKALVQGMEAIRQHSQDTLLEALQQLRLSIQDITRALAQMHDYVDPDIFYSVIRIFLSGWKDNPAMPVGLVYEGVATEPLKYSGGSAAQSSVLHAFDEFLGIEHCKESVGFLHRMRDYMPPSHKAFLEDLHVAPSLRDYILASGPGDCLMAYNQCVEALGELRSYHINVVARYIISAATRARSRGLTNPSPHALEDRGTGGTAMLSFLKSVREKTMEALLCPGA
uniprot
proteins
ec_number
1.13.11.-
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism (PubMed:17499941). Involved in immune regulation (PubMed:25477879). {ECO:0000269|PubMed:17499941, ECO:0000303|PubMed:25477879}.
uniprot
proteins
mass_dalton
45255
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
uniprot
proteins
protein_family
3-dioxygenase family
uniprot
proteins
protein_family
Indoleamine 2
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17499941
uniprot
proteins
pubmed
17671174
uniprot
proteins
pubmed
18026683
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24402311
uniprot
proteins
pubmed
25477879
uniprot
proteins
pubmed
25691885
uniprot
proteins
sequence_length
405
uniprot
proteins