CCDC57
entrez
284001
canonical
uniprot
Q2TAC2
canonical
ensembl
ENSG00000176155
resolver
ensp
ENSP00000374292
resolver
ensp
ENSP00000376154
resolver
ensp
ENSP00000499556
resolver
ensp
ENSP00000511565
resolver
ensp
ENSP00000545384
resolver
ensp
ENSP00000545385
resolver
ensp
ENSP00000619643
resolver
enst
ENST00000665763
resolver
enst
ENST00000694881
resolver
enst
ENST00000875325
resolver
enst
ENST00000875326
resolver
enst
ENST00000949584
resolver
genesymbol
CCDC57
resolver
hgnc
HGNC:27564
resolver
uniprot
A0A590UJT6
resolver
uniprot
A6NP51
resolver
uniprot
A8MQC7
resolver
uniprot
Q8IWG2
resolver
uniprot
Q8TER3
resolver
uniprot_entry
A0A590UJT6_HUMAN
resolver
uniprot_entry
CCD57_HUMAN
resolver
uniprot_sec
A6NP51
resolver
uniprot_sec
A8MQC7
resolver
uniprot_sec
Q8IWG2
resolver
uniprot_sec
Q8TER3
resolver
amino_acid_sequence
MLPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQIPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVHLEVLELRKQVAELGKHLRIAQHGGAEPSGRKQPPASDAVALGREDAKSAEDEAPSRHLGKHQPRSAQVGSRLDALQGPKTQHSIHTVTCKSPRQKEDRSPKPPQAPQHPEEHGRQSHSSSSFASGTLQDMWRLLDLGSSPSGVTSQGDSTPELPAPPAADRRPVKMQAGIATPGMKTAAQAKAKTTGASRSHPAKAKGCQRPPKIRNYNIMD
uniprot
proteins
function
FUNCTION: Pleiotropic regulator of centriole duplication, mitosis, and ciliogenesis. Critical interface between centrosome and microtubule-mediated cellular processes. Centriole duplication protein required for recruitment of CEP63, CEP152, and PLK4 to the centrosome. Independent of its centrosomal targeting, localizes to and interacts with microtubules and regulates microtubule nucleation, stability, and mitotic progression. {ECO:0000269|PubMed:32402286}.
uniprot
proteins
mass_dalton
103039
uniprot
proteins
pubmed
12693554
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
32402286
uniprot
proteins
sequence_length
915
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:32402286}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:32402286}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:32402286}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:32402286}. Note=Localizes to resolvable rings at the proximal end of centrioles (PubMed:32402286). In mitotic cells, localizes to spindle microtubules during metaphase (PubMed:32402286). {ECO:0000269|PubMed:32402286}.
uniprot
proteins