Tbx3
entrez
21386
canonical
uniprot
P70324
canonical
ensembl
ENSMUSG00000018604
resolver
ensp
ENSMUSP00000018748
resolver
ensp
ENSMUSP00000112519
resolver
genesymbol
Tbx3
resolver
uniprot
E9QM97
resolver
uniprot
Q3ULL3
resolver
uniprot
Q4VA43
resolver
uniprot
Q60708
resolver
uniprot
Q8BWH7
resolver
uniprot_entry
Q3ULL3_MOUSE
resolver
uniprot_entry
Q4VA43_MOUSE
resolver
uniprot_entry
TBX3_MOUSE
resolver
uniprot_sec
E9QM97
resolver
uniprot_sec
Q60708
resolver
uniprot_sec
Q8BWH7
resolver
amino_acid_sequence
MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEDVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVFEERHKKETSDESSSEQAAFNCFAQASSPAVSIVGTSNLKDLCPSEAESDAEAESKEEHGPEACDAAKISTTTAEEPGRDKGSPATRAQLFPAEPSRARDTARLDKASPDSRHSPATISSSTRVPGADERRSPGREGPVATKVDEARAIPAKDAFAPLSVQTDATAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPGQFAMGGAFSSMAAGMGPLLATVSGASTGVSGLESTAMASAAAAQGLSGASAATLPFHLQQHVLASQGLAMSPFGSLFPYPYTYMAAAAAASTAAASSSVHRHPFLNLNSMRPRLRYSPYSIPVPVPDSSSLLATALPSMASAAGPLDGKAAALAASPASVAVDSGSELNSRSSTLSSGSVSLSPKLCSEKEAATSELQSIQRLVSGLEAKPDRSCSGSP
uniprot
proteins
function
FUNCTION: Transcriptional repressor involved in developmental processes (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (By similarity). Probably plays a role in limb pattern formation (By similarity). Required for mammary placode induction, and maintenance of the mammary buds during development (PubMed:16222716). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (PubMed:16222716, PubMed:27720610). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (PubMed:27720610). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (PubMed:33795231). Acts as a negative regulator of PML function in cellular senescence (By similarity). {ECO:0000250|UniProtKB:O15119, ECO:0000269|PubMed:16222716, ECO:0000269|PubMed:27720610, ECO:0000269|PubMed:33795231}.
uniprot
proteins
mass_dalton
79160
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16222716
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27720610
uniprot
proteins
pubmed
33795231
uniprot
proteins
pubmed
7920656
uniprot
proteins
pubmed
8853987
uniprot
proteins
pubmed
8878690
uniprot
proteins
sequence_length
741
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
uniprot
proteins