Scn1b
entrez
20266
canonical
uniprot
P97952
canonical
ensembl
ENSMUSG00000019194
resolver
ensp
ENSMUSP00000096148
resolver
ensp
ENSMUSP00000148295
resolver
enst
ENSMUST00000098548
resolver
enst
ENSMUST00000211945
resolver
genesymbol
Scn1b
resolver
uniprot_entry
SCN1B_MOUSE
resolver
amino_acid_sequence
MGTLLALVVGAALVSSAWGGCVEVDSDTEAVYGMTFKILCISCKRRSETTAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFDNYEHNTSVVKKIHLEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMVYCYKKIAAATEAAAQENASEYLAITSESKENCTGVQVAE
uniprot
proteins
function
FUNCTION: Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes (By similarity). Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient (By similarity). The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (By similarity). The accessory beta subunits participate in localization and functional modulation of the Nav channels (By similarity). Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN4A/Nav1.4, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8 (By similarity). {ECO:0000250|UniProtKB:Q07699}.
uniprot
proteins
mass_dalton
24650
uniprot
proteins
protein_family
Sodium channel auxiliary subunit SCN1B (TC 8.A.17) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19710327
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36257954
uniprot
proteins
pubmed
9013777
uniprot
proteins
pubmed
9721701
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19710327}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q07699}. Perikaryon {ECO:0000269|PubMed:19710327}. Cell projection {ECO:0000269|PubMed:19710327}. Cell projection, axon {ECO:0000250|UniProtKB:Q00954}. Note=Detected at nodes of Ranvier on the sciatic nerve. {ECO:0000269|PubMed:19710327}.
uniprot
proteins
transmembrane_region
TRANSMEM 158..179; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q07699
uniprot
proteins