DDI1
entrez
414301
canonical
uniprot
Q8WTU0
canonical
ensembl
ENSG00000170967
resolver
ensp
ENSP00000302805
resolver
enst
ENST00000302259
resolver
genesymbol
DDI1
resolver
hgnc
HGNC:18961
resolver
uniprot
Q7Z4U6
resolver
uniprot
Q8WTS3
resolver
uniprot_entry
DDI1_HUMAN
resolver
uniprot_sec
Q7Z4U6
resolver
uniprot_sec
Q8WTS3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the proteinase inhibitors amprenavir, indinavir, lopinavir, isovaleryl pepstatin, ritonavir and saquinavir. {ECO:0000269|PubMed:21266539}.
uniprot
proteins
amino_acid_sequence
MLITVYCVRRDLSEVTFSLQVSPDFELRNFKVLCEAESRVPVEEIQIIHMERLLIEDHCSLGSYGLKDGDIVVLLQKDNVGPRAPGRAPNQPRVDFSGIAVPGTSSSRPQHPGQQQQRTPAAQRSQGLASGEKVAGLQGLGSPALIRSMLLSNPHDLSLLKERNPPLAEALLSGSLETFSQVLMEQQREKALREQERLRLYTADPLDREAQAKIEEEIRQQNIEENMNIAIEEAPESFGQVTMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGVAKGVGTQRIIGRVHLAQIQIEGDFLQCSFSILEDQPMDMLLGLDMLRRHQCSIDLKKNVLVIGTTGTQTYFLPEGELPLCSRMVSGQDESSDKEITHSVMDSGRKEH
uniprot
proteins
ec_number
3.4.23.-
uniprot
proteins
function
FUNCTION: Probable aspartic protease (Probable). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI2, for cellular survival following replication stress. Together or redundantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612). {ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:21266539, ECO:0000305|PubMed:29290612}.
uniprot
proteins
mass_dalton
44124
uniprot
proteins
protein_family
DDI1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21266539
uniprot
proteins
pubmed
29290612
uniprot
proteins
sequence_length
396
uniprot
proteins