Elane
entrez
50701
canonical
uniprot
Q3UP87
canonical
ensembl
ENSMUSG00000020125
resolver
ensp
ENSMUSP00000038925
resolver
enst
ENSMUST00000046091
resolver
genesymbol
Elane
resolver
genesymbol_syn
Ela2
resolver
uniprot
A6H698
resolver
uniprot
Q61515
resolver
uniprot_entry
ELNE_MOUSE
resolver
uniprot_sec
A6H698
resolver
uniprot_sec
Q61515
resolver
amino_acid_sequence
MALGRLSSRTLAAMLLALFLGGPALASEIVGGRPARPHAWPFMASLQRRGGHFCGATLIARNFVMSAAHCVNGLNFRSVQVVLGAHDLRRQERTRQTFSVQRIFENGFDPSQLLNDIVIIQLNGSATINANVQVAQLPAQGQGVGDRTPCLAMGWGRLGTNRPSPSVLQELNVTVVTNMCRRRVNVCTLVPRRQAGICFGDSGGPLVCNNLVQGIDSFIRGGCGSGLYPDAFAPVAEFADWINSIIRSHNDHLLTHPKDREGRTN
uniprot
proteins
ec_number
3.4.21.37
uniprot
proteins
function
FUNCTION: Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes (PubMed:10947984). Shows microbicidal activity in neutrophils by mediating cleavage and degradation of bacterial proteins (By similarity). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed:10947984). Involved for the formation of neutrophil extracellular traps (NETs): translocates into the nucleus downstream of MPO and mediates degadation of histone H4, thereby participating to chromatin decondensation (PubMed:20974816, PubMed:32045782). NETs are mainly composed of DNA fibers and are released by neutrophils to trap pathogens during inflammation (By similarity). Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (By similarity). Promotes cleavage of GSDMB, thereby inhibiting pyroptosis (By similarity). Promotes blood coagulation (PubMed:20676107). Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG) (By similarity). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI) (By similarity). {ECO:0000250|UniProtKB:P08246, ECO:0000269|PubMed:10947984, ECO:0000269|PubMed:20676107, ECO:0000269|PubMed:20974816, ECO:0000269|PubMed:32045782}.
uniprot
proteins
mass_dalton
28648
uniprot
proteins
protein_family
Elastase subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10947984
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20676107
uniprot
proteins
pubmed
20974816
uniprot
proteins
pubmed
32045782
uniprot
proteins
pubmed
8035830
uniprot
proteins
sequence_length
265
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P08246}. Lysosome {ECO:0000250|UniProtKB:P08246}. Cytolytic granule {ECO:0000250|UniProtKB:P08246}. Nucleus {ECO:0000250|UniProtKB:P08246}. Note=Localizes to azurophil granules, a type of primary lysosome found in neutrophils and monocytes that contains antimicrobial proteins (By similarity). Translocates from azurophil granules to the nucleus downstream of MPO during formation of neutrophil extracellular traps (NETs), and is present in released NETs (PubMed:32045782). Localized in phagolysosomes following ingestion of E.coli by neutrophils (By similarity). {ECO:0000250|UniProtKB:P08246, ECO:0000269|PubMed:32045782}.
uniprot
proteins