Ccnd1
entrez
58919
canonical
uniprot
P39948
canonical
ensembl
ENSRNOG00000020918
resolver
ensembl
ENSRNOG00055020798
resolver
ensembl
ENSRNOG00060031868
resolver
ensembl
ENSRNOG00065029228
resolver
ensp
ENSRNOP00000075372
resolver
ensp
ENSRNOP00055028802
resolver
ensp
ENSRNOP00060045690
resolver
ensp
ENSRNOP00065041493
resolver
enst
ENSRNOT00000088588
resolver
enst
ENSRNOT00055035513
resolver
enst
ENSRNOT00060055245
resolver
enst
ENSRNOT00065050489
resolver
genesymbol
Ccnd1
resolver
uniprot_entry
CCND1_RAT
resolver
amino_acid_sequence
MEHQLLCCEVETIRRAYPDTNLLNDRVLRAMLKTEETCAPSVSYFKCVQREIVPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPLKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEADENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAMQGLNLGSPNNFLSCYRTTHFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNIDPKATEEEGEVEEEAGLACTPTDVRDVDI
uniprot
proteins
function
FUNCTION: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. {ECO:0000250|UniProtKB:P24385}.
uniprot
proteins
mass_dalton
33483
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex. It also plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex following DNA damage. {ECO:0000250|UniProtKB:P24385}.; PTM: Ubiquitinated at Lys-269 by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation: ubiquitination is dependent on Thr-286 phosphorylation. The DCX(AMBRA1) complex represents the major regulator of CCND1 stability during the G1/S transition (By similarity). Also ubiquitinated by the SCF(FBXO4) and Cul7-RING(FBXW8) ubiquitin-protein ligase complexes (By similarity). Following DNA damage it is ubiquitinated by the SCF(FBXO31) protein ligase complex. SCF(FBXO31) ubiquitination is dependent on Thr-286 phosphorylation. Ubiquitinated also by UHRF2 apparently in a phosphorylation-independent manner. Ubiquitination leads to its degradation and G1 arrest. Deubiquitinated by USP2; leading to its stabilization (By similarity). Ubiquitinated by FBXO32 at Lys-58 via 'Lys27'-linked polyubiquitination; leading to its stabilization (By similarity). {ECO:0000250|UniProtKB:P24385, ECO:0000250|UniProtKB:P25322}.
uniprot
proteins
protein_family
Cyclin D subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
7980531
uniprot
proteins
pubmed
8336937
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P24385}. Cytoplasm {ECO:0000250|UniProtKB:P24385}. Nucleus membrane {ECO:0000250|UniProtKB:P24385}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250|UniProtKB:P24385}.
uniprot
proteins