Serpina3g
entrez
20715
canonical
uniprot
Q5I2A0
canonical
ensembl
ENSMUSG00000041481
resolver
ensp
ENSMUSP00000041250
resolver
ensp
ENSMUSP00000201081
resolver
enst
ENSMUST00000043315
resolver
genesymbol
Serpina3g
resolver
genesymbol_syn
Spi2A
resolver
uniprot
F2Z405
resolver
uniprot
Q3U0Y1
resolver
uniprot
Q6PG99
resolver
uniprot_entry
F2Z405_MOUSE
resolver
uniprot_entry
Q3U0Y1_MOUSE
resolver
uniprot_entry
SPA3G_MOUSE
resolver
uniprot_sec
Q6PG99
resolver
amino_acid_sequence
MAGVSPAVFGCPDVTLGRNTAVREVQENVTSVDSLTLVSSNTDFAFSLYRKLVLKNPDENVVFSPFSICTALALLSLGAKSNTLKEILEGLKFNLTETPEPDIHQGFRYLLDLLSQPGNQVQISTGSALFIEKHLQILAEFKEKARALYQAEAFTADFQQPLKATKLINDYVSNHTQGKIKELISGLKESTLMVLVNYIYFKGKWKNPFDPNDTFKSEFYLDEKRSVIVSMMKTGYLTTPYFRDEELSCTVVELKYTGNASAMFILPDQGRMQQVEASLQPETLRKWKNSLKPRMIHELRLPKFSISTDYSLEHILPELGIREVFSTQADLSAITGTKDLRVSQVVHKAVLDVAETGTEAAAATGMAGVGCCAVFDFLEIFFNRPFLMIISDTKAHIALFMAKVTNPERSMNFPNGEGASSQRLESKRLCFGDPLCLIGQ
uniprot
proteins
function
FUNCTION: Serine and cysteine protease inhibitor. Can inhibit lysosomal papain-like proteases including the cathepsins B, G, H, K, L and V. Ineffective against elastase, granzyme A, granzyme B, or caspases 3, 8 or 9. Inhibition of cytoplasmic cathepsin B following release from the lysosome may protect cells from apoptosis. This may facilitate the survival of progenitor T-cells and the subsequent development of long term memory CD8 T-cells. {ECO:0000269|PubMed:14517268, ECO:0000269|PubMed:15225607, ECO:0000269|PubMed:15311278}.
uniprot
proteins
mass_dalton
49021
uniprot
proteins
protein_family
Serpin family
uniprot
proteins
pubmed
11438738
uniprot
proteins
pubmed
12470299
uniprot
proteins
pubmed
12659817
uniprot
proteins
pubmed
14517268
uniprot
proteins
pubmed
15225607
uniprot
proteins
pubmed
15311278
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15638460
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8978283
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
uniprot
proteins