QTRT2
entrez
79691
canonical
uniprot
Q9H974
canonical
ensembl
ENSG00000151576
resolver
ensp
ENSP00000281273
resolver
ensp
ENSP00000418056
resolver
ensp
ENSP00000419169
resolver
ensp
ENSP00000420682
resolver
ensp
ENSP00000731735
resolver
genesymbol
QTRT2
resolver
genesymbol_syn
QTRTD1
resolver
hgnc
HGNC:25771
resolver
uniprot
A6NGE9
resolver
uniprot
B7Z472
resolver
uniprot
B7Z5R2
resolver
uniprot
J3KR78
resolver
uniprot
Q6IA59
resolver
uniprot_entry
QTRT2_HUMAN
resolver
uniprot_sec
A6NGE9
resolver
uniprot_sec
B7Z472
resolver
uniprot_sec
B7Z5R2
resolver
uniprot_sec
J3KR78
resolver
uniprot_sec
Q6IA59
resolver
amino_acid_sequence
MKLSLTKVVNGCRLGKIKNLGKTGDHTMDIPGCLLYTKTGSAPHLTHHTLHNIHGVPAMAQLTLSSLAEHHEVLTEYKEGVGKFIGMPESLLYCSLHDPVSPCPAGYVTNKSVSVWSVAGRVEMTVSKFMAIQKALQPDWFQCLSDGEVSCKEATSIKRVRKSVDRSLLFLDNCLRLQEESEVLQKSVIIGVIEGGDVMEERLRSARETAKRPVGGFLLDGFQGNPTTLEARLRLLSSVTAELPEDKPRLISGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFSFDYQPNPEETLLQQNGTQEEIKCMDQIKKIETTGCNQEITSFEINLKEKKYQEDFNPLVRGCSCYCCKNHTRAYIHHLLVTNELLAGVLLMMHNFEHYFGFFHYIREALKSDKLAQLKELIHRQAS
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). {ECO:0000255|HAMAP-Rule:MF_03043, ECO:0000269|PubMed:34009357, ECO:0000269|PubMed:34241577}.
uniprot
proteins
mass_dalton
46713
uniprot
proteins
mutagenesis
MUTAGEN 116; /note="W->A: Does not significantly affect ability to promote formation of hypermodified nucleoside queuosine tRNA."; /evidence="ECO:0000269|PubMed:34241577"; MUTAGEN 118; /note="V->D: Does not significantly affect ability to promote formation of hypermodified nucleoside queuosine tRNA."; /evidence="ECO:0000269|PubMed:34241577"; MUTAGEN 121; /note="R->E: Decreased affinity for tRNAs, leading to decreased formation of hypermodified nucleoside queuosine tRNA."; /evidence="ECO:0000269|PubMed:34241577"; MUTAGEN 152; /note="K->E: Does not significantly affect ability to promote formation of hypermodified nucleoside queuosine tRNA."; /evidence="ECO:0000269|PubMed:34241577"; MUTAGEN 158..161; /note="KRVR->ERVS: Decreased affinity for tRNAs."; /evidence="ECO:0000269|PubMed:34241577"; MUTAGEN 158; /note="K->E,S: Does not significantly affect ability to promote formation of hypermodified nucleoside queuosine tRNA."; /evidence="ECO:0000269|PubMed:34241577"; MUTAGEN 161; /note="R->E: Does not significantly affect ability to promote formation of hypermodified nucleoside queuosine tRNA."; /evidence="ECO:0000269|PubMed:34241577
uniprot
proteins
protein_family
QTRT2 subfamily
uniprot
proteins
protein_family
Queuine tRNA-ribosyltransferase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20354154
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
30149595
uniprot
proteins
pubmed
34009357
uniprot
proteins
pubmed
34241577
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03043}. Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03043}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03043}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03043}. Note=May associate with the mitochondrion outer membrane. {ECO:0000255|HAMAP-Rule:MF_03043}.
uniprot
proteins