Entpd2
entrez
12496
canonical
uniprot
O55026
canonical
ensembl
ENSMUSG00000015085
resolver
ensp
ENSMUSP00000028328
resolver
genesymbol
Entpd2
resolver
genesymbol_syn
Cd39l1
resolver
uniprot
O35928
resolver
uniprot
Q921R1
resolver
uniprot
Q9DCR9
resolver
uniprot_entry
ENTP2_MOUSE
resolver
uniprot_entry
Q921R1_MOUSE
resolver
uniprot_sec
O35928
resolver
uniprot_sec
Q9DCR9
resolver
amino_acid_sequence
MAGKLVSLVPPLLLAAVGLAGLLLLCVPTQDVREPPALKYGIVLDAGSSHTSMFVYKWPADKENDTGIVGQHSSCDVRGGGISSYANDPSRAGQSLVECLEQALRDVPKDRYASTPLYLGATAGMRLLNLTSPEATAKVLEAVTQTLTRYPFDFRGARILSGQDEGVFGWVTANYLLENFIKYGWVGRWIRPRKGTLGAMDLGGASTQITFETTSPSEDPDNEVHLRLYGQHYRVYTHSFLCYGRDQVLQRLLASALQIHRFHPCWPKGYSTQVLLREVYQSPCTMGQRPQTFNSSATVSLSGTSNAALCRDLVSGLFNISSCPFSQCSFNGVFQPPVAGNFIAFSAFYYTVDFLKTVMGLPVGTLKQLEDATETTCNQTWAELQARVPGQQTRLPDYCAVAMFIHQLLSRGYRFDERSFRGVVFEKKAADTAVGWALGYMLNLTNLIPADLPGLRKGTHFSSWVALLLLFTVLILAALVLLLRQVRSAKSPGAL
uniprot
proteins
ec_number
3.6.1.5
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs), with a marked preference for triphosphonucleosides over diphosphonucleosides (PubMed:18404504, PubMed:9624117). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:18404504, PubMed:9624117). This activity contributes to the regulation of extracellular nucleotides levels (PubMed:18404504, PubMed:9624117). ATP hydrolysis is characterized by fast ADP accumulation and delayed AMP formation, reflecting limited ADP hydrolase activity (By similarity). Hydrolyzes ADP and UDP only to a marginal extent, and does not hydrolyze AMP (PubMed:18404504, PubMed:9624117). All nucleoside 5'-diphosphates are hydrolyzed at rates lower than those of their corresponding triphosphates (By similarity). {ECO:0000250|UniProtKB:O35795, ECO:0000269|PubMed:18404504, ECO:0000269|PubMed:9624117}.
uniprot
proteins
mass_dalton
54319
uniprot
proteins
protein_family
GDA1/CD39 NTPase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18404504
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9271669
uniprot
proteins
pubmed
9624117
uniprot
proteins
sequence_length
495
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Long]: Cell membrane {ECO:0000250|UniProtKB:Q9Y5L3}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 463..483; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins