Tspan12
entrez
269831
canonical
uniprot
Q8BKT6
canonical
ensembl
ENSMUSG00000029669
resolver
ensp
ENSMUSP00000031678
resolver
ensp
ENSMUSP00000113384
resolver
ensp
ENSMUSP00000195902
resolver
ensp
ENSMUSP00000195905
resolver
ensp
ENSMUSP00000195910
resolver
ensp
ENSMUSP00000349360
resolver
genesymbol
Tspan12
resolver
genesymbol_syn
Tm4sf12
resolver
uniprot
Q6P1C3
resolver
uniprot
Q8BZU1
resolver
uniprot_entry
TSN12_MOUSE
resolver
uniprot_sec
Q6P1C3
resolver
uniprot_sec
Q8BZU1
resolver
amino_acid_sequence
MAREDSVKCLRCLLYALNLLFWLMSISVLAVSAWMRDYLNNVLTLTAETRVEEAVILTYFPVVHPVMIAVCCFLIIVGMLGYCGTVKRNLLLLAWYFGTLLVIFCVELACGVWTYEQEVMVPVQWSDMVTLKARMTNYGLPRYRWLTHAWNYFQREFKCCGVVYFTDWLEMTEMDWPPDSCCVREFPGCSKQAHQEDLSDLYQEGCGKKMYSFLRGTKQLQVLRFLGISIGVTQILAMILTITLLWALYYDRREPGTDQMLSLKNDTSQHLSCHSVELLKPSLSRIFEHTSMANSFNTHFEMEEL
uniprot
proteins
function
FUNCTION: Regulator of cell surface receptor signal transduction. Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity). Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). {ECO:0000250, ECO:0000269|PubMed:19837033}.
uniprot
proteins
mass_dalton
35408
uniprot
proteins
post_translational_modification
PTM: Palmitoylated; required for interaction with ADAM10. {ECO:0000250}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19837033
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:19837033}; Multi-pass membrane protein {ECO:0000305|PubMed:19837033}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 60..80; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins