Sycp3
entrez
25561
canonical
uniprot
Q63520
canonical
ensembl
ENSRNOG00000005270
resolver
ensp
ENSRNOP00000087777
resolver
genesymbol
Sycp3
resolver
genesymbol_syn
Scp3
resolver
uniprot_entry
SYCP3_RAT
resolver
amino_acid_sequence
MLRGCGEVGAVDCSPEQLNKHLKMVPGGRKHSGKSGKPPLIDQPKKAFDFEKEDKDLSGSEEDAVDEKTQVFDKHGKKRSAGIIEDVGGEVQNMLEKFGADINKALLAKKKRIEMYTKASFKASNQKIEQIWKTQQEEIQKLNNEYSQQFLSVLQQWELDMQKFEEQGEKLTNLFRQQQKIFQQTRIVQSQRMKAIKQLHEQFIKSLEDVEKNNDNLFTGTQSELKKEMAMLQKKVMMETQQQEMANVRKSLQSMLF
uniprot
proteins
function
FUNCTION: Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:8289794, PubMed:9933407). Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2. {ECO:0000250|UniProtKB:P70281, ECO:0000269|PubMed:8289794, ECO:0000269|PubMed:9933407}.
uniprot
proteins
mass_dalton
29733
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:P70281}.
uniprot
proteins
protein_family
XLR/SYCP3 family
uniprot
proteins
pubmed
10652260
uniprot
proteins
pubmed
18391527
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8289794
uniprot
proteins
pubmed
9679134
uniprot
proteins
pubmed
9933407
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18391527, ECO:0000269|PubMed:9679134}. Chromosome {ECO:0000269|PubMed:8289794, ECO:0000269|PubMed:9933407}. Chromosome, centromere {ECO:0000250|UniProtKB:Q60547}. Note=It is present in early unpaired cores, in the lateral domains of the synaptonemal complex and in the chromosome cores when they separate at diplotene. It is found axial to the metaphase I chromosomes and in association with pairs of sister centromeres. The centromere-associated protein becomes dissociated from the centromeres at anaphase II and is not found in mitotic metaphase centromeres. {ECO:0000250|UniProtKB:Q60547}.
uniprot
proteins