MAFG
entrez
4097
canonical
uniprot
O15525
canonical
ensembl
ENSG00000197063
resolver
ensp
ENSP00000350369
resolver
ensp
ENSP00000376173
resolver
ensp
ENSP00000569756
resolver
ensp
ENSP00000569757
resolver
ensp
ENSP00000569758
resolver
ensp
ENSP00000569759
resolver
ensp
ENSP00000569760
resolver
ensp
ENSP00000569761
resolver
ensp
ENSP00000602448
resolver
ensp
ENSP00000623207
resolver
ensp
ENSP00000623208
resolver
ensp
ENSP00000623209
resolver
ensp
ENSP00000623210
resolver
ensp
ENSP00000623211
resolver
ensp
ENSP00000623212
resolver
ensp
ENSP00000623213
resolver
enst
ENST00000357736
resolver
enst
ENST00000392366
resolver
enst
ENST00000899697
resolver
enst
ENST00000899698
resolver
enst
ENST00000899699
resolver
enst
ENST00000899700
resolver
enst
ENST00000899701
resolver
enst
ENST00000899702
resolver
enst
ENST00000932389
resolver
enst
ENST00000953148
resolver
enst
ENST00000953149
resolver
enst
ENST00000953150
resolver
enst
ENST00000953151
resolver
enst
ENST00000953152
resolver
enst
ENST00000953153
resolver
enst
ENST00000953154
resolver
genesymbol
MAFG
resolver
hgnc
HGNC:6781
resolver
uniprot_entry
MAFG_HUMAN
resolver
amino_acid_sequence
MTTPNKGNKALKVKREPGENGTSLTDEELVTMSVRELNQHLRGLSKEEIVQLKQRRRTLKNRGYAASCRVKRVTQKEELEKQKAELQQEVEKLASENASMKLELDALRSKYEALQTFARTVARSPVAPARGPLAAGLGPLVPGKVAATSVITIVKSKTDARS
uniprot
proteins
function
FUNCTION: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:11154691, PubMed:8932385, PubMed:9421508). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:11154691). May be involved in signal transduction of extracellular H(+) (By similarity). {ECO:0000250|UniProtKB:Q76MX4, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:8932385, ECO:0000269|PubMed:9421508}.
uniprot
proteins
mass_dalton
17850
uniprot
proteins
mutagenesis
MUTAGEN 53; /note="K->A: Abolishes acetylation. Has no effect on binding to NFE2 but impairs the DNA binding and transcriptional activities of NFE2; when associated with A-60; A-71 and A-76."; /evidence="ECO:0000269|PubMed:11154691"; MUTAGEN 60; /note="K->A: Abolishes acetylation. Has no effect on binding to NFE2 but impairs the DNA binding and transcriptional activities of NFE2; when associated with A-53; A-71 and A-76."; /evidence="ECO:0000269|PubMed:11154691"; MUTAGEN 71; /note="K->A: Abolishes acetylation. Has no effect on binding to NFE2 but impairs the DNA binding and transcriptional activities of NFE2; when associated with A-53; A-60; and A-76."; /evidence="ECO:0000269|PubMed:11154691"; MUTAGEN 76; /note="K->A: Abolishes acetylation. Has no effect on binding to NFE2 but impairs the DNA binding and transcriptional activities of NFE2; when associated with A-53; A-60 and A-71."; /evidence="ECO:0000269|PubMed:11154691
uniprot
proteins
post_translational_modification
PTM: Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2. {ECO:0000269|PubMed:11154691}.; PTM: Sumoylation at Lys-14 is required for active transcriptional repression. {ECO:0000250|UniProtKB:O54790}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
Maf subfamily
uniprot
proteins
pubmed
11154691
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
8932385
uniprot
proteins
pubmed
9150357
uniprot
proteins
pubmed
9166829
uniprot
proteins
pubmed
9195958
uniprot
proteins
pubmed
9286713
uniprot
proteins
pubmed
9421508
uniprot
proteins
sequence_length
162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:11154691}.
uniprot
proteins