Ntn1
entrez
18208
canonical
uniprot
O09118
canonical
ensembl
ENSMUSG00000020902
resolver
ensp
ENSMUSP00000021284
resolver
ensp
ENSMUSP00000104314
resolver
enst
ENSMUST00000021284
resolver
enst
ENSMUST00000108674
resolver
genesymbol
Ntn1
resolver
uniprot
B1ARR0
resolver
uniprot
Q60832
resolver
uniprot
Q9QY50
resolver
uniprot_entry
NET1_MOUSE
resolver
uniprot_sec
B1ARR0
resolver
uniprot_sec
Q60832
resolver
uniprot_sec
Q9QY50
resolver
amino_acid_sequence
MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNSSDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYYYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGFYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSVEEPEDCDSYCKASKGKLKMNMKKYCRKDYAVQIHILKADKAGDWWKFTVNIISVYKQGTSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPDQSGIVADKSSLVIQWRDTWARRLRKFQQREKKGKCKKA
uniprot
proteins
function
FUNCTION: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis (By similarity). {ECO:0000250|UniProtKB:O95631, ECO:0000269|PubMed:10381568, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:8978605}.
uniprot
proteins
mass_dalton
67810
uniprot
proteins
pubmed
10381568
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18585357
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27068745
uniprot
proteins
pubmed
28483977
uniprot
proteins
pubmed
7604039
uniprot
proteins
pubmed
8978605
uniprot
proteins
sequence_length
604
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7604039}. Cytoplasm {ECO:0000250|UniProtKB:O95631}. Note=Mainly secreted. {ECO:0000269|PubMed:7604039}.
uniprot
proteins