Nat8b
entrez
171084
canonical
uniprot
Q9JIY6
canonical
ensembl
ENSRNOG00000056962
resolver
ensembl
ENSRNOG00055012664
resolver
ensembl
ENSRNOG00060026515
resolver
ensembl
ENSRNOG00065017088
resolver
ensp
ENSRNOP00000068791
resolver
ensp
ENSRNOP00000078918
resolver
ensp
ENSRNOP00055017533
resolver
ensp
ENSRNOP00055017535
resolver
ensp
ENSRNOP00055017537
resolver
ensp
ENSRNOP00060038093
resolver
ensp
ENSRNOP00060038104
resolver
ensp
ENSRNOP00060038120
resolver
ensp
ENSRNOP00065022583
resolver
ensp
ENSRNOP00065022587
resolver
ensp
ENSRNOP00065022589
resolver
enst
ENSRNOT00000088557
resolver
enst
ENSRNOT00000096643
resolver
enst
ENSRNOT00055021618
resolver
enst
ENSRNOT00055021621
resolver
enst
ENSRNOT00055021623
resolver
enst
ENSRNOT00060045900
resolver
enst
ENSRNOT00060045911
resolver
enst
ENSRNOT00060045926
resolver
enst
ENSRNOT00065028529
resolver
enst
ENSRNOT00065028533
resolver
enst
ENSRNOT00065028535
resolver
genesymbol
Nat8b
resolver
genesymbol_syn
Cml1
resolver
genesymbol_syn
Cml6
resolver
uniprot_entry
NAT8B_RAT
resolver
amino_acid_sequence
MVSYHICEYQDSDYKSVVDVFTKGAEEYIPSTFRHLLLLPRTLLLLLGVSLALVLVSGSWLLAVVCIFFLLPFLWFLAGQPWKNYVSKCLHTDMADITKSYLSDRGSGFWVAESGEQVVGTVGALPVKEPPSGRKQLQLFHLAVSSQHRGQGIAKALVRTVLQFARDQGYTDVVLETSTMQIGAVTLYLGMGFQKTGQYFPSMLWRLVGIRFVQLNYSFPSA
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER)-membrane-bound lysine N-acetyltransferase catalyzing the N6-acetylation of lysine residues in the lumen of the ER in various proteins, including PROM1 and BACE1, using acetyl-CoA as acetyl donor. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. Acetylates and stabilizes BACE1 immature protein, leading to increased steady-state levels in neurons. By acting on BACE1 expression, may regulate amyloid beta-peptide formation (By similarity). N(6)-lysine acetylation in ER maintains protein homeostasis and regulates reticulophagy (By similarity). {ECO:0000250|UniProtKB:E0CYC6, ECO:0000250|UniProtKB:Q9UHF3}.
uniprot
proteins
mass_dalton
24809
uniprot
proteins
post_translational_modification
PTM: Acetylation on Lys-99 modulates enzymatic activity. {ECO:0000250|UniProtKB:Q9UHF3}.
uniprot
proteins
protein_family
NAT8 family
uniprot
proteins
pubmed
11397015
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q9UHF3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9UHF3}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UHF3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9UHF3}. Note=Enriched in the endoplasmic reticulum-Golgi intermediate compartment. {ECO:0000250|UniProtKB:Q9UHF3}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..67; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins