ARFIP2
entrez
23647
canonical
uniprot
P53365
canonical
ensembl
ENSG00000132254
resolver
ensp
ENSP00000254584
resolver
ensp
ENSP00000379998
resolver
ensp
ENSP00000391427
resolver
ensp
ENSP00000398375
resolver
ensp
ENSP00000484121
resolver
ensp
ENSP00000530103
resolver
ensp
ENSP00000530104
resolver
ensp
ENSP00000530105
resolver
ensp
ENSP00000530109
resolver
ensp
ENSP00000530110
resolver
ensp
ENSP00000601190
resolver
ensp
ENSP00000601191
resolver
ensp
ENSP00000678762
resolver
enst
ENST00000614314
resolver
enst
ENST00000860045
resolver
genesymbol
ARFIP2
resolver
genesymbol_syn
POR1
resolver
hgnc
HGNC:17160
resolver
uniprot
A0A087X1E4
resolver
uniprot
B4DUZ3
resolver
uniprot
B4DX86
resolver
uniprot
B4DXH2
resolver
uniprot
B4E306
resolver
uniprot
D3DQT5
resolver
uniprot_entry
A0A087X1E4_HUMAN
resolver
uniprot_entry
ARFP2_HUMAN
resolver
uniprot_entry
B4DUZ3_HUMAN
resolver
uniprot_entry
B4DXH2_HUMAN
resolver
uniprot_sec
B4DX86
resolver
uniprot_sec
B4E306
resolver
uniprot_sec
D3DQT5
resolver
amino_acid_sequence
MTDGILGKAATMEIPIHGNGEARQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTTPSGPGDEVARGIAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQAHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ
uniprot
proteins
function
FUNCTION: Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network (PubMed:26507660). May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 (PubMed:26507660). Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site (PubMed:30917996, PubMed:31204568). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG (PubMed:26296658). {ECO:0000269|PubMed:26296658, ECO:0000269|PubMed:26507660, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:31204568, ECO:0000269|PubMed:33773106}.
uniprot
proteins
mass_dalton
37856
uniprot
proteins
mutagenesis
MUTAGEN 99; /note="W->A: Abolished ability to regulate ATG9A trafficking."; /evidence="ECO:0000269|PubMed:30917996
uniprot
proteins
pubmed
11303027
uniprot
proteins
pubmed
11346801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21239483
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22679020
uniprot
proteins
pubmed
22981988
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26296658
uniprot
proteins
pubmed
26507660
uniprot
proteins
pubmed
30917996
uniprot
proteins
pubmed
31204568
uniprot
proteins
pubmed
33773106
uniprot
proteins
pubmed
8670882
uniprot
proteins
pubmed
9038142
uniprot
proteins
sequence_length
341
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:22981988}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21239483, ECO:0000269|PubMed:22679020, ECO:0000269|PubMed:26507660, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:31204568}.
uniprot
proteins