Pclo
entrez
26875
canonical
uniprot
Q9QYX7
canonical
ensembl
ENSMUSG00000061601
resolver
ensp
ENSMUSP00000030691
resolver
ensp
ENSMUSP00000138419
resolver
genesymbol
Pclo
resolver
genesymbol_syn
Acz
resolver
uniprot
E9QK94
resolver
uniprot
Q8CF91
resolver
uniprot
Q8CF92
resolver
uniprot
Q9QYX6
resolver
uniprot
Q9QZJ0
resolver
uniprot_entry
PCLO_MOUSE
resolver
uniprot_sec
E9QK94
resolver
uniprot_sec
Q8CF91
resolver
uniprot_sec
Q8CF92
resolver
uniprot_sec
Q9QYX6
resolver
uniprot_sec
Q9QZJ0
resolver
amino_acid_sequence
MGNEASLEGEGLPEGLAAAAGGAGGSGSALHPGIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPAAAAESPSMHRKQELDSSQAPQQPGKPPDPGRPPQHGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDFKEEYKSSMMPGFFSDVNPLSAVSSVVNKFNPFDLISDSEAVQEETTKKQKVAQKDQGKSEGITKPSLQQPSPKLIPKQQGPGKEVIPQDIPSKSVSSQQAEKTKPQAPGTAKPSQQSPAQTPAQQAKPVAQQPGPAKATVQQPGPAKSPAQPAGTGKSPAQPPVTAKPPAQQAGLEKTSLQQPGPKSLAQTPGQGKVPPGPAKSPAQQPGTAKLPAQQPGPQTAAKVPGPTKTPAQLSGPGKTPAQQPGPTKPSPQQPIPAKPQPQQPVATKPQPQQPAPAKPQPQHPTPAKPQPQHPTPAKPQPQQPTPAKPQPQQPTPAKPQPQQPTPAKPQPQHPTPAKPQPQQPGLGKPSAQQPSKSISQTVTGRPLQAPPTSAAQAPAQGLSKTICPLCNTTELLLHTPEKANFNTCTECQSTVCSLCGFNPNPHLTEIKEWLCLNCQMQRALGGELAAIPSSPQPTPKAASVQPATASKSPVPSQQASPKKELPSKQDSPKAPESKKPPPLVKQPTLHGPTPATAPQPPVAEALPKPAPPKKPSAALPEQAKAPVADVEPKQPKTTETLTDSPSSAAATSKPAILSSQVQAQAQVTTAPPLKTDSAKTSQSFPPTGDTITPLDSKAMPRPASDSKIVSHPGPTSESKDPVQKKEEPKKAQTKVTPKPDTKPVPKGSPTPSGTRPTTGQATPQSQQPPKPPEQSRRFSLNLGGIADAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQQAPHPQTGPAAPSKQAPPPSQTLAAQGPPKSTGPHPSAPAKTTAVKKETKGPAAENLEAKPVQAPTVKKAEKDKKPPPGKVSKPPPTEPEKAVLAQKPDKTTKPKPACPLCRTELNVGSQDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDMDKMPPASSGPKASPVPAPAEPPPQKTPTAAHAKGKKKETEVKAETEKQIPEKETPSIEKTPPAVATDQKLEESEVTKSLVSVLPEKKPSEEEKALPADKKEKKPPAAEAPPLEEKKPIPDDQKLPPDAKPSASEGEEKRDLLKAHVQIPEEGPIGKVASLACEGEQQPDTRPEDLPGATPQTLPKDRQKESRDVTQPQAEGTAKEGRGEPSKDRTEKEEDKSDTSSSQQPKSPQGLSDTGYSSDGISGSLGEIPSLIPSDEKDLLKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLVGEKAEKKTQPQKVSPEQPQDQQKTQTPSETRDISISEEEIKESQEKKVTSKKDSAQGFPSRKEHKENPELVDDLSPRRASYDSVEDSSESENSPVARRKRRTSIGSSSSEEYKQEDSQGSGEDEDFIRKQIIEMSADEDASGSEDEEFIRSQLKEIGGVTESQKREETKGKGKSPAGKHRRLTRKSSTSFDDDAGRRHSWHDEDDETFDESPELKFRETKSQESEELVVAGGGGLRRFKTIELNSTVTDKYSAESSQKKTTLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRSHGPLLPTIEDSSEEEELREEEELLKEQEKQRELEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSVMQKEGAQKALKSAEEMYEEMMHKPHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLVEDTYNGSVDGSLLTRQDEQNGFMQQRGREQKIRLQEQIYDDPMQKITDLQKEFYELESLHSIVPQEDIVSSSYIIPESHEIVDLGSMVTSTSEEKKLLDADAAYEELMKRQQMQVTDGSSLIQTTMGDDMAESTLDFDRVQDASLTSSILSGASLTDSTSSATLSIPDVKITQHFSTEEFEDEYVTDYTREIQEIIAHESLILTYSEPSESATSVPPSDTPSLTSSISSVCTTDSSSPVTTLDSLTTVYTEPADVITKFKDSEEISSTYFPGSVIDYPEDIGVSLDRTITPESRTNADQIMISFPGIAPSITESVATKPERPQADTISTDLPISEKELIKGKKETGDGIILEVLDAYKDKREESEAELTKISLPETGLAPTPSSQTKEQPGSPHSVSGEILGQEKPTYRSPSGGLPVSTHPSKSHPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPATSPKPPTYPKRKLAAAAPVAPTAIVTAHADAIPTVEATAARRSNGLPATKICAAAPPPVPPKPSSIPTGLVFTHRPEASKPPIAPKPAVPEIPVTTQKTTDTCPKPTGLPLTSNMSLNLVTSADYKLPSPTSPLSPHSNKSSPRYSKSLMETYVVITLPSEPGTPTDSSAAQAITSWPLGSPPKDLVSLETVFSVVPPMTSTEIPSASQPTLYTSGALGTFSVTPAVTASLFQTVPTSLTQFLPAEASKPEVSAVSSAVPSVAPRSVSIPIPPEPLALDRHQYKENGKLPLIGDAIDLRTIPKSEVKVTEKCMDLSASAMDVKRQTTANEVYRRQISAVQPSIINLSAASSLGTPVTMDSKTVAVVTCTDTTIYTTGTESQVGIEHAVTSPLQLTTSKHTELQYRKPSSQAFPMIRDEAPINLSLGPSTQAVTLAVTKPVTVPPVGVTNGWTDSTISQGITDGEVVDLSTSKSHRTVVTMDESTSNVVTKIIEDEEKPVDLTAGRRAVCCDMVYKLPFGRSCTAQQPATTLPEDRFGYRDDHYQYDRSGPYGYRGIGGMKPSMSDTNLAEAGHFFYKSKNAFDYSGGTEAAVDLTSGRVSTGEVMDYSSKTTGPYPETRQVISGVGISTPQYSTARMTPPPGPQYGVGSVLRSSNGVVYSSVATPIPSTFAITTQPGSIFSTTVRDLSGIHTTDAITSLSALHQSQPMPRSYFITTGASETDISVTSIDINASLQTITMETLPAETMDSVPTLTTASEVFSEVVGEESTLLIVPDEDKQQQQLDLERELLELEKIKQQRFAEELEWERQEIQRFREQEKIMVQKKLEELQSMKQHLLYQQEEERQAQFMMRQETLAQQQLQLEQIQQLQQQLHQQLEEQKLRQIYQYNYEPSGTASPQTTTEQAILEGQYVATEGSQFWATEDATTTASTVVAIEIPQSQGWYTVQSDGVTQYIAPPGILSTVSEIPLTDVVVKEEKQPKKRSSGAKVRGQYDEMGESMADDPRNLKKIVDSGVQTDDEETADRTYASRRRRTKKSVDTSVQTDDEDQDEWDMPSRSRRKARTGKYGDSTAEGDKTKPPSKVSSVAVQTVAEISVQTEPLGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTETDPDTQSPPYMGATSPPKDKKRPTPLEIGYSSSHLRADPTVQLAPSPPKSPKVLYSPISPLSPGHALEPAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYSEGFTAKGSQTTSGTQKKVKRTLPNPPPEEASTGTQSTYSTMGTASRRRMCRTNTMARAKILQDIDRELDLVERESAKLRKKQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTRPSRVESQHGIERPRTAPQTEFSQFIPPQTQTEAQLVPPTSPYTQYQYSSPALPTQAPTPYTQQSHFQQQTLYHQQVSPYQTQPTFQAVATMSFTPQAQPTPTPQPSYQLPSQMMVIQQKPRQTTLYLEPKITSTYEVIRNQPLMIAPVSTDNTYAVSHLGSKYNSLDLRIGLEERSSMASSPISSISADSFYADIDHHTSRNYVLIDDIGDITKGTAALSSAFSLHEKDLSKTDRLLRTTETRRSQEVTDFLAPLQTSSRLHSYVKAEEDSMEDPYELKLLKHQIKQEFRRGTESLDHLAGLSHYYHADTSYRHFPKSEKYSISRLTLEKQAAKQLPAAILYQKQSKHKKALIDPKMSKFSPIQESRDLEPDYPTYLSSSTSSIGGISSRARLLQDDITFGLRKNITDQQKFMGSSLGSGLGTLGNTIRSALQDEADKPYSSGSRSRPSSRPSSVYGLDLSIKRDSSSSSLRLKAQEAEALDVSFGHSSSSARTKPTSLPISQSRGRIPIVAQNSEEESPLSPVGQPMGMARAAAGPLPPISADTRDQFGSSHSLPEVQQHMREESRTRGYDRDIAFIMDDFQHAMSDSEAYHLRREETDWFDKPRESRLENGHGLDRKLPERLVHSRPLSQHQEQILQMNGKTMHYIFPHARIKITRDSKDHTVSGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEHSGKLIEGMQVLEWNGIPLTSKTYEEVQSIINQQSGEAEICVRLDLNMLSDSENPQHLELHEPPKVVDKAKSPGVDPKQLAAELQKVSLQQSPLVMSSVVEKGAHAHSGPTSAGSSSVPSPGQPGSPSVSKKKHGGSKPTDVSKTASHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASVEYKRRTKYVQKSLNPEWNQTVIYKSISMEQLMKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIEHGKSHSSQNSQQSPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVAQTHLEDAGAAIAAAEAAVQQLRIQPTKPTNHRPAETSVSTGSSGSSVGSGYSVDSEGSSCVAGEPNLLPIPRIGKMGQNGQDPVKQPGMGAADTEAKTQVMGEIKLALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPDLYVKIYVINIATQKKVIKKKTRVCRHDREPSFNETFRFSLSPAGHSLQILLFSNGGKFMKKTLIGEACIWLDKVDLRKRIVNWHKLLMSPTQTH
uniprot
proteins
function
FUNCTION: Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:19812333). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (By similarity) (PubMed:28231469). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). {ECO:0000250|UniProtKB:Q9JKS6, ECO:0000269|PubMed:19812333, ECO:0000269|PubMed:28231469}.
uniprot
proteins
mass_dalton
550834
uniprot
proteins
pubmed
10508862
uniprot
proteins
pubmed
12401793
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
16452088
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19812333
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28231469
uniprot
proteins
sequence_length
5068
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Presynaptic active zone {ECO:0000269|PubMed:10508862}. Note=Colocalizes with BSN in developing axons. {ECO:0000250|UniProtKB:Q9JKS6}.
uniprot
proteins