Bfar
entrez
67118
canonical
uniprot
Q8R079
canonical
ensembl
ENSMUSG00000022684
resolver
ensp
ENSMUSP00000023365
resolver
ensp
ENSMUSP00000063371
resolver
enst
ENSMUST00000023365
resolver
genesymbol
Bfar
resolver
uniprot
A0A0R4J040
resolver
uniprot
Q8C1A7
resolver
uniprot
Q9CXY3
resolver
uniprot_entry
A0A0R4J040_MOUSE
resolver
uniprot_entry
BFAR_MOUSE
resolver
uniprot_sec
Q8C1A7
resolver
uniprot_sec
Q9CXY3
resolver
amino_acid_sequence
MEEPQKNDLSMREQEEEHPVRSSGPQISVSEFSCHCCYDTLVNPTTLNCGHSFCRHCLALWWMSSKKTECPECREKWEGFPKVNILLRDAIEKLFPDAIRMRVEDIQQNNDVVQSLAAFQKYGNDQNPLAPSTGRVNPQRGGGFFSGVLTALTGVAVILLVYHWRSRESEHGLLVHKAVDKWTMEEVVLWLEQLGPWASLYRDRFLSERVNGRLLLTLTEEEFSRAPYTIENSSHRRVILTELERVRALGVKPPQNLWEYKAVNPGRSLFLLYALKSSPRLGLLYLYLFDYTDCFLPFIHTICPLQENSSGEDIFTKLLDLREPTWKQWREFLVKYSFLPYQLIAEFAWDWLEVHYWTSRFLIVNAVLLSVLELFSFWRIWSRSELKTVPQRMWSHFWKVSTQGLFMAMFWPLIPQFVCNCLFYWALYFNPIINIDLVVKEVRRLETQVL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Membrane-bound E3 ubiquitin ligase that plays a role in several processes including apoptosis regulation or reticulum endoplasmic stress. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. Contributes to the dynamic control of IRE1/ERN1 signaling during ER stress by inducing BAX inhibitor 1/TMBIM6 proteasomal degradation. Promotes the activation of TGF-beta signaling by mediating the 'Lys-63'-linked ubiquitination of TGFBR1 which is critical to activate the pathway. Together with NGFR, negatively regulates NF-kappa-B and JNK-related signaling pathways (By similarity). Promotes the proteasome-mediated degradation of PNPLA3, a protein involveld in lipid metabolism (PubMed:38294943). {ECO:0000250|UniProtKB:Q9NZS9, ECO:0000269|PubMed:38294943}.
uniprot
proteins
mass_dalton
52968
uniprot
proteins
post_translational_modification
PTM: Mediates RING-dependent self-ubiquitination leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q9NZS9}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
38294943
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NZS9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NZS9}.
uniprot
proteins
transmembrane_region
TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 332..352; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 361..381; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 405..425; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins