Rap1b
entrez
171337
canonical
uniprot
Q62636
canonical
ensembl
ENSRNOG00000007048
resolver
ensembl
ENSRNOG00055012790
resolver
ensembl
ENSRNOG00060009294
resolver
ensembl
ENSRNOG00065013006
resolver
ensp
ENSRNOP00000078778
resolver
ensp
ENSRNOP00055017717
resolver
ensp
ENSRNOP00060012219
resolver
ensp
ENSRNOP00065016474
resolver
enst
ENSRNOT00000113270
resolver
enst
ENSRNOT00055021874
resolver
enst
ENSRNOT00060015682
resolver
enst
ENSRNOT00065021314
resolver
genesymbol
Rap1b
resolver
uniprot
Q6J167
resolver
uniprot_entry
RAP1B_RAT
resolver
uniprot_sec
Q6J167
resolver
activity_regulation
ACTIVITY REGULATION: Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner. {ECO:0000250|UniProtKB:P61224}.
uniprot
proteins
amino_acid_sequence
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWSNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSSCQLL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity). {ECO:0000250|UniProtKB:P61224}.
uniprot
proteins
mass_dalton
20798
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P61224}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P61224}. Cell junction {ECO:0000250|UniProtKB:P61224}. Note=May shuttle between plasma membrane and cytosol (By similarity). Presence of KRIT1 and CDH5 is required for its localization to the cell junction (By similarity). {ECO:0000250|UniProtKB:P61224}.
uniprot
proteins