O35119
uniprot
O35119
canonical
activity_regulation
ACTIVITY REGULATION: May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G protein coupled receptors (PubMed:11713258). May be activated by intracellular calcium store depletion (By similarity). {ECO:0000250|UniProtKB:Q9QUQ5, ECO:0000269|PubMed:11713258}.
uniprot
proteins
amino_acid_sequence
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTDFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIREAKTEEGLTEENVKELKQDISSFRFEVLGLLRGSKLSTIQSANAASSASSADSDEKSHSEGNGKDKRKNLSLFDLTTLIHPRSAVIASERHNLSNGSALVVQEPPREKQRKVNFVADIKNFGLFHRRSKQNAAEQNANQIFSVSEEITRQQAAGALERNIQLESKGLASRGDRSIPGLNEQCVLVDHRERNTDTLGLQVGKRVCSSFKSEKVVVEDTVPIIPKEKHAQEEDSSIDYDLSPTDTVAHEDYVTTRL
uniprot
proteins
function
FUNCTION: [Isoform Alpha]: Forms a receptor-activated non-selective calcium permeant cation channel (By similarity). Acts as a cell-cell contact-dependent endothelial calcium entry channel (By similarity). Forms a homomeric ion channel or a heteromeric ion channel with TRPC1; the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel (By similarity). Also permeable to monovalent ions including sodium, lithium and cesium ions (By similarity). {ECO:0000250|UniProtKB:Q9UBN4}.; FUNCTION: [Isoform Beta]: Forms a non-selective a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G protein-coupled receptors. {ECO:0000269|PubMed:11713258}.
uniprot
proteins
mass_dalton
111848
uniprot
proteins
protein_family
STrpC subfamily
uniprot
proteins
protein_family
TRPC4 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
10980202
uniprot
proteins
pubmed
11713258
uniprot
proteins
pubmed
12857742
uniprot
proteins
pubmed
9037541
uniprot
proteins
sequence_length
977
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Alpha]: Cell membrane {ECO:0000269|PubMed:11713258}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UBN4}.; SUBCELLULAR LOCATION: [Isoform Beta]: Cell membrane {ECO:0000269|PubMed:11713258}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UBN4}.
uniprot
proteins
transmembrane_region
TRANSMEM 363..383; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:Q9UBN4"; TRANSMEM 404..418; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:Q9UBN4"; TRANSMEM 433..453; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:Q9UBN4"; TRANSMEM 476..498; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:Q9UBN4"; TRANSMEM 512..534; /note="Helical; Name=S5"; /evidence="ECO:0000250|UniProtKB:Q9UBN4"; TRANSMEM 600..620; /note="Helical; Name=S6"; /evidence="ECO:0000250|UniProtKB:Q9UBN4
uniprot
proteins