DROSHA
entrez
29102
canonical
uniprot
Q9NRR4
canonical
ensembl
ENSG00000113360
resolver
ensp
ENSP00000339845
resolver
ensp
ENSP00000424161
resolver
ensp
ENSP00000425979
resolver
genesymbol
DROSHA
resolver
genesymbol_syn
RN3
resolver
genesymbol_syn
RNASE3L
resolver
genesymbol_syn
RNASEN
resolver
hgnc
HGNC:17904
resolver
uniprot
E7EMP9
resolver
uniprot
Q7Z5V2
resolver
uniprot
Q86YH0
resolver
uniprot
Q9NW73
resolver
uniprot
Q9Y2V9
resolver
uniprot
Q9Y4Y0
resolver
uniprot_entry
RNC_HUMAN
resolver
uniprot_sec
E7EMP9
resolver
uniprot_sec
Q7Z5V2
resolver
uniprot_sec
Q86YH0
resolver
uniprot_sec
Q9NW73
resolver
uniprot_sec
Q9Y2V9
resolver
uniprot_sec
Q9Y4Y0
resolver
amino_acid_sequence
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQGPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPPSFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYDRGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREKKRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLDREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEYAITNDKTKRPVALRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQAEMGAAMDALEKYNFPQMAHQKRFIERKYRQELKEMRWEREHQEREPDETEDIKK
uniprot
proteins
ec_number
3.1.26.3
uniprot
proteins
function
FUNCTION: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons (By similarity). {ECO:0000250|UniProtKB:Q5HZJ0, ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}.
uniprot
proteins
mass_dalton
159316
uniprot
proteins
mutagenesis
MUTAGEN 536; /note="C->A: Impairs protein folding and stability; when associated with A-538."; /evidence="ECO:0000269|PubMed:26748718"; MUTAGEN 538; /note="C->A: Impairs protein folding and stability; when associated with A-536."; /evidence="ECO:0000269|PubMed:26748718"; MUTAGEN 561; /note="C->A: Impairs protein folding and stability."; /evidence="ECO:0000269|PubMed:26748718"; MUTAGEN 622..623; /note="RF->AA: Abolishes RNase activity."; /evidence="ECO:0000269|PubMed:26748718"; MUTAGEN 676; /note="C->A: Impairs protein folding and stability."; /evidence="ECO:0000269|PubMed:26748718"; MUTAGEN 835..836; /note="RR->AA: Abolishes RNase activity."; /evidence="ECO:0000269|PubMed:26748718"; MUTAGEN 914; /note="R->M: Impairs RNase activity."; /evidence="ECO:0000269|PubMed:26748718"; MUTAGEN 923; /note="R->A: Abolishes RNase activity; when associated with A-927."; /evidence="ECO:0000269|PubMed:26748718"; MUTAGEN 927; /note="Y->A: Abolishes RNase activity; when associated with A-923."; /evidence="ECO:0000269|PubMed:26748718"; MUTAGEN 938..940; /note="RKK->QQQ: Abolishes RNase activity."; /evidence="ECO:0000269|PubMed:26748718"; MUTAGEN 993; /note="E->A,Q: No effect on pri-miRNA processing activity."; /evidence="ECO:0000269|PubMed:15574589"; MUTAGEN 1045; /note="E->Q: Impairs pri-miRNA processing activity. Abolishes cleavage of the 3' strand. Abolishes enzyme activity; when associated with Q-1222."; /evidence="ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:26027739"; MUTAGEN 1077; /note="V->E: Loss of one DGCR8 interaction site; no effect on the second DGCR8 interaction site."; /evidence="ECO:0000269|PubMed:26748718"; MUTAGEN 1171; /note="E->A,Q: No effect on pri-miRNA processing activity."; /evidence="ECO:0000269|PubMed:15574589"; MUTAGEN 1194; /note="L->R: Abolishes interaction with DGCR8."; /evidence="ECO:0000269|PubMed:26748718"; MUTAGEN 1222; /note="E->Q: Impairs pri-miRNA processing activity. Abolishes cleavage of the 5' strand. Abolishes enzyme activity; when associated with Q-1045."; /evidence="ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:26027739"; MUTAGEN 1243; /note="V->D: Abolishes interaction with DGCR8."; /evidence="ECO:0000269|PubMed:26748718
uniprot
proteins
post_translational_modification
PTM: Degraded by autophagy in response to neuronal activity in motor neurons. {ECO:0000250|UniProtKB:Q5HZJ0}.
uniprot
proteins
protein_family
Ribonuclease III family
uniprot
proteins
pubmed
10948199
uniprot
proteins
pubmed
10976766
uniprot
proteins
pubmed
14508493
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15531877
uniprot
proteins
pubmed
15565168
uniprot
proteins
pubmed
15574589
uniprot
proteins
pubmed
15589161
uniprot
proteins
pubmed
16751099
uniprot
proteins
pubmed
16906129
uniprot
proteins
pubmed
17159994
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18632581
uniprot
proteins
pubmed
20226070
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22118463
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26027739
uniprot
proteins
pubmed
26748718
uniprot
proteins
pubmed
31819270
uniprot
proteins
sequence_length
1374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:22118463}. Nucleus, nucleolus {ECO:0000269|PubMed:10948199}. Cytoplasm {ECO:0000250|UniProtKB:Q5HZJ0}. Note=A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies. {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:22118463}.
uniprot
proteins