Metap2
entrez
64370
canonical
uniprot
P38062
canonical
ensembl
ENSRNOG00000021881
resolver
ensp
ENSRNOP00000030415
resolver
ensp
ENSRNOP00000032680
resolver
ensp
ENSRNOP00000087571
resolver
enst
ENSRNOT00000031571
resolver
enst
ENSRNOT00000110473
resolver
genesymbol
Metap2
resolver
genesymbol_syn
METAP2
resolver
genesymbol_syn
Mnpep
resolver
genesymbol_syn
P67eif2
resolver
genesymbol_syn
RGD1560341
resolver
uniprot
A0A8I6A902
resolver
uniprot
A0ACM8Q444
resolver
uniprot
F7FJ19
resolver
uniprot
Q5BKA1
resolver
uniprot
Q6IRK1
resolver
uniprot_entry
A0A8I6A902_RAT
resolver
uniprot_entry
A0ACM8Q444_RAT
resolver
uniprot_entry
MAP2_RAT
resolver
uniprot_entry
Q5BKA1_RAT
resolver
uniprot_entry
Q6IRK1_RAT
resolver
uniprot_sec
F7FJ19
resolver
amino_acid_sequence
MAGVEEASSFGGHLNRDLDPDDREEGTSSTAEEAAKKKRRKKKKGKGAVSAGQQELDKESGTSVDEVAKQLERQALEEKEKDDDDEDGDGDGDGAAGKKKKKKKKKRGPRVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDILLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
uniprot
proteins
ec_number
3.4.11.18
uniprot
proteins
function
FUNCTION: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).; FUNCTION: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
uniprot
proteins
mass_dalton
53052
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains 12 O-linked GlcNAc. {ECO:0000269|PubMed:12731887}.; PTM: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding. {ECO:0000255|HAMAP-Rule:MF_03175}.
uniprot
proteins
protein_family
Methionine aminopeptidase eukaryotic type 2 subfamily
uniprot
proteins
protein_family
Peptidase M24A family
uniprot
proteins
pubmed
12731887
uniprot
proteins
pubmed
16857189
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7644482
uniprot
proteins
pubmed
8496145
uniprot
proteins
pubmed
9705841
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Note=About 30% of expressed METAP2 associates with polysomes. {ECO:0000255|HAMAP-Rule:MF_03175}.
uniprot
proteins