Pex2
entrez
19302
canonical
uniprot
P55098
canonical
ensembl
ENSMUSG00000040374
resolver
ensp
ENSMUSP00000059415
resolver
ensp
ENSMUSP00000071255
resolver
ensp
ENSMUSP00000126445
resolver
ensp
ENSMUSP00000129311
resolver
ensp
ENSMUSP00000141927
resolver
ensp
ENSMUSP00000141945
resolver
ensp
ENSMUSP00000190385
resolver
ensp
ENSMUSP00000190386
resolver
ensp
ENSMUSP00000190387
resolver
ensp
ENSMUSP00000190388
resolver
ensp
ENSMUSP00000190389
resolver
ensp
ENSMUSP00000190391
resolver
ensp
ENSMUSP00000190392
resolver
ensp
ENSMUSP00000190397
resolver
ensp
ENSMUSP00000190399
resolver
ensp
ENSMUSP00000190406
resolver
ensp
ENSMUSP00000190409
resolver
ensp
ENSMUSP00000190411
resolver
enst
ENSMUST00000059021
resolver
enst
ENSMUST00000071280
resolver
enst
ENSMUST00000164828
resolver
enst
ENSMUST00000165309
resolver
enst
ENSMUST00000191916
resolver
enst
ENSMUST00000195855
resolver
genesymbol
Pex2
resolver
genesymbol_syn
Paf1
resolver
genesymbol_syn
Pmp35
resolver
genesymbol_syn
Pxmp3
resolver
uniprot
F7AV61
resolver
uniprot
O35467
resolver
uniprot
Q91YZ5
resolver
uniprot_entry
F7AV61_MOUSE
resolver
uniprot_entry
PEX2_MOUSE
resolver
uniprot_entry
Q91YZ5_MOUSE
resolver
uniprot_sec
O35467
resolver
amino_acid_sequence
MAAREESTQSANRVLRISQLDALELNKALEQLVWSQFTQCFHGFKPGLLARFEPEVKAFLWLFLWRFTIYSKNATVGQSVLNIQHKNDSSPNPVYQPPSKNQKLLYAVCTIGGRWLEERCYDLFRNRHLASFGKAKQCMNFVVGLLKLGELMNFLIFLQKGKFATLTERLLGIHSVFCKPQNMREVGFEYMNRELLWHGFAEFLIFLLPLINIQKLKAKLSSWCTLCTGAAGHDSTLGSSGKECALCGEWPTMPHTIGCEHVFCYYCVKSSFLFDIYFTCPKCGTEVHSVQPLKAGIQMSEVNAL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
ec_number
2.3.2.36
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity). PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity). Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70 (By similarity). Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis (PubMed:34903883). {ECO:0000250|UniProtKB:P28328, ECO:0000250|UniProtKB:P32800, ECO:0000269|PubMed:34903883}.
uniprot
proteins
mass_dalton
34732
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:P28328}.
uniprot
proteins
post_translational_modification
PTM: Forms intramolecular and intermolecular disulfide bonds in response to reactive oxygen species (ROS), promoting higher stability. {ECO:0000250|UniProtKB:P28328}.
uniprot
proteins
protein_family
Pex2/pex10/pex12 family
uniprot
proteins
pubmed
12746876
uniprot
proteins
pubmed
14673138
uniprot
proteins
pubmed
19110480
uniprot
proteins
pubmed
22441164
uniprot
proteins
pubmed
33163488
uniprot
proteins
pubmed
34903883
uniprot
proteins
pubmed
8043297
uniprot
proteins
pubmed
9382874
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250|UniProtKB:P28328}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..42; /note="Helical; Name=TM1"; /evidence="ECO:0000250|UniProtKB:G2Q1C9"; TRANSMEM 49..74; /note="Helical; Name=TM2"; /evidence="ECO:0000250|UniProtKB:G2Q1C9"; TRANSMEM 99..125; /note="Helical; Name=TM3"; /evidence="ECO:0000250|UniProtKB:G2Q1C9"; TRANSMEM 134..160; /note="Helical; Name=TM4"; /evidence="ECO:0000250|UniProtKB:G2Q1C9"; TRANSMEM 188..211; /note="Helical; Name=TM5"; /evidence="ECO:0000250|UniProtKB:G2Q1C9
uniprot
proteins