Nherf1
entrez
59114
canonical
uniprot
Q9JJ19
canonical
ensembl
ENSRNOG00000003232
resolver
ensembl
ENSRNOG00065021568
resolver
ensp
ENSRNOP00000103366
resolver
ensp
ENSRNOP00065029495
resolver
enst
ENSRNOT00000170226
resolver
enst
ENSRNOT00065036648
resolver
genesymbol
Nherf1
resolver
genesymbol_syn
Nherf
resolver
genesymbol_syn
Slc9a3r1
resolver
uniprot_entry
NHRF1_RAT
resolver
amino_acid_sequence
MSADAAAGEPLPRLCCLEKGPNGYGFHLHGEKGKVGQFIRLVEPGSPAEKSGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLKKLGVPIREELLRAQEKSEHTEPPAAADTKKAGDQNEAEKSHLERCELRPRLCTMKKGPNGYGFNLHSDKSKPGQFIRAVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIKAGGDEAKLLVVDKETDEFFKKCRVTPSQEHLDGPLPEPFSNGEIQKENSREALVEPASESPRPALARSASSDTSEELNAQDSPKRHDSTEPSSTSSSSDPILDFNISLAVAKERAHQKRSSKRAPQMDWSKKNELFSNL
uniprot
proteins
function
FUNCTION: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
38830
uniprot
proteins
pubmed
10859298
uniprot
proteins
pubmed
11457882
uniprot
proteins
pubmed
12444018
uniprot
proteins
pubmed
16396499
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Apical cell membrane {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cell projection, microvillus {ECO:0000250}. Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Present in lipid rafts of T-cells. Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). {ECO:0000250}.
uniprot
proteins