Arid4a
entrez
238247
canonical
uniprot
F8VPQ2
canonical
ensembl
ENSMUSG00000048118
resolver
ensp
ENSMUSP00000035512
resolver
enst
ENSMUST00000046305
resolver
genesymbol
Arid4a
resolver
genesymbol_syn
Rbbp1
resolver
genesymbol_syn
Rbp1
resolver
uniprot
B2RXT8
resolver
uniprot
B2RY61
resolver
uniprot
Q05CI2
resolver
uniprot
Q6PE90
resolver
uniprot_entry
ARI4A_MOUSE
resolver
uniprot_sec
B2RXT8
resolver
uniprot_sec
B2RY61
resolver
uniprot_sec
Q05CI2
resolver
uniprot_sec
Q6PE90
resolver
amino_acid_sequence
MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPLRVGAIVETRTSDGSIQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETLDQLPLTNPEHFGTPVIAKKTNRGRRSSLPITEDEKEEESSEEEDEDKRRLNDELLGKVVSVASTAESTGWYPALVVSPSCNDDVTVKKDQCLVRSFIDSKFYSIARKDIKELDILTLPESELCARPGLRRASVFLKGRIVPDNWKMDISEILESSSSDDEECPAEEHEEEKEKEAKKEEEELPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCGNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTIHHHEPKVKEEKKDFEDSMDEALKEAPEMPLLDVKSEPEENTDSNSESDREDTELKSPRGRRKIVRDANCIKKEIEEEKIEDKFLRDDLENKDAGDDDDDGDPAAKREHELLFGRKSTPKNKEKKIKKPEDSERDSDEEEEKSQEREETESRCDSEGEDEEDDTEPCLTGTKVKVKYGRGKTQKIYEASIKSTEMDDGEILYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKVKNKEDSEKDEKRDEERQKSKRGRPPLKSTFSPNMPYSLSKTSNSEGKSDSCSSDSEADDQLEKSSGGEDLSPDVKEELEKNENAHDDKLDEENPKIVHISKENDRTQAQPSDTLTVEAGDSDQIVHIFGDKVDQVEEFKKQVEKSPKGKGRRSKTKDLSLELIKISPFGQEEAGSEAHGDVHSLEFSSLECKNFSSTEDDIDPYEKEKKLKRKILGQQSPEKKLRLDNGMEMTTGVSQERSDDGAGAEGMKGAHVEQHFETEGEGMPSLTAEPDQGLQELTSEKSDSPAEEEPVHTPLKEEEDAMPLIGPETLVCHEVDLDDLDEKDKTSIEDVVVEGSESNSLASVPPALPPVAQHNFSVASPLTLSQDESRSIKSESDITIEVDSIAEESQEGLCERESANGFEASVASGACSIIAHERESREKGQKRPSDGNSGLIAKKQKRTPKRTSAAAKTEKNGAGQSSDSEDLPAMDSSSNCTPVKRLTLPKSQKLPRSPARTSPHIKDAEKEKHREKHPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSPSSSSPPQNVLAVECR
uniprot
proteins
function
FUNCTION: DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (PubMed:17043311, PubMed:23487765). May function as part of an mSin3A repressor complex (By similarity). Has no intrinsic transcriptional activity (PubMed:23487765). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (PubMed:17043311). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation (PubMed:23487765). Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (PubMed:23487765). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis (PubMed:18728284). May function as a leukemia suppressor (PubMed:18728284). {ECO:0000250|UniProtKB:P29374, ECO:0000269|PubMed:17043311, ECO:0000269|PubMed:18728284, ECO:0000269|PubMed:23487765}.
uniprot
proteins
mass_dalton
142055
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15922553
uniprot
proteins
pubmed
17043311
uniprot
proteins
pubmed
18728284
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23487765
uniprot
proteins
sequence_length
1261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305|PubMed:17043311, ECO:0000305|PubMed:23487765}.
uniprot
proteins