MXI1
entrez
4601
canonical
uniprot
P50539
canonical
ensembl
ENSG00000119950
resolver
ensp
ENSP00000239007
resolver
ensp
ENSP00000331152
resolver
ensp
ENSP00000354606
resolver
genesymbol
MXI1
resolver
genesymbol_syn
BHLHC11
resolver
hgnc
HGNC:7534
resolver
uniprot
A0A0S2Z3X5
resolver
uniprot
B1ANN7
resolver
uniprot
D3DR25
resolver
uniprot
D3DRA9
resolver
uniprot
Q15887
resolver
uniprot
Q6FHW2
resolver
uniprot
Q96E53
resolver
uniprot_entry
A0A0S2Z3X5_HUMAN
resolver
uniprot_entry
MXI1_HUMAN
resolver
uniprot_sec
B1ANN7
resolver
uniprot_sec
D3DR25
resolver
uniprot_sec
D3DRA9
resolver
uniprot_sec
Q15887
resolver
uniprot_sec
Q6FHW2
resolver
uniprot_sec
Q96E53
resolver
amino_acid_sequence
MERVKMINVQRLLEAAEFLERRERECEHGYASSFPSMPSPRLQHSKPPRRLSRAQKHSSGSSNTSTANRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS
uniprot
proteins
disease_involvement
DISEASE: Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269|PubMed:7773287}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
uniprot
proteins
mass_dalton
26062
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7773287
uniprot
proteins
pubmed
7789959
uniprot
proteins
pubmed
8425219
uniprot
proteins
pubmed
8838813
uniprot
proteins
pubmed
8918230
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins