TDRD3
entrez
81550
canonical
uniprot
Q9H7E2
canonical
ensembl
ENSG00000083544
resolver
ensp
ENSP00000196169
resolver
ensp
ENSP00000367113
resolver
ensp
ENSP00000367126
resolver
ensp
ENSP00000648378
resolver
ensp
ENSP00000790992
resolver
genesymbol
TDRD3
resolver
hgnc
HGNC:20612
resolver
uniprot
B2MWP9
resolver
uniprot
Q53XA6
resolver
uniprot
Q6P992
resolver
uniprot_entry
TDRD3_HUMAN
resolver
uniprot_sec
B2MWP9
resolver
uniprot_sec
Q53XA6
resolver
uniprot_sec
Q6P992
resolver
amino_acid_sequence
MLRLQMTDGHISCTAVEFSYMSKISLNTPPGTKVKLSGIVDIKNGFLLLNDSNTTVLGGEVEHLIEKWELQRSLSKHNRSNIGTEGGPPPFVPFGQKCVSHVQVDSRELDRRKTLQVTMPVKPTNDNDEFEKQRTAAIAEVAKSKETKTFGGGGGGARSNLNMNAAGNRNREVLQKEKSTKSEGKHEGVYRELVDEKALKHITEMGFSKEASRQALMDNGNNLEAALNVLLTSNKQKPVMGPPLRGRGKGRGRIRSEDEEDLGNARPSAPSTLFDFLESKMGTLNVEEPKSQPQQLHQGQYRSSNTEQNGVKDNNHLRHPPRNDTRQPRNEKPPRFQRDSQNSKSVLEGSGLPRNRGSERPSTSSVSEVWAEDRIKCDRPYSRYDRTKDTSYPLGSQHSDGAFKKRDNSMQSRSGKGPSFAEAKENPLPQGSVDYNNQKRGKRESQTSIPDYFYDRKSQTINNEAFSGIKIEKHFNVNTDYQNPVRSNSFIGVPNGEVEMPLKGRRIGPIKPAGPVTAVPCDDKIFYNSGPKRRSGPIKPEKILESSIPMEYAKMWKPGDECFALYWEDNKFYRAEVEALHSSGMTAVVKFIDYGNYEEVLLSNIKPIQTEAWEEEGTYDQTLEFRRGGDGQPRRSTRPTQQFYQPPRARN
uniprot
proteins
function
FUNCTION: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins (PubMed:15955813). Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci (PubMed:21172665). In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1 (PubMed:35085371). {ECO:0000269|PubMed:15955813, ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:21172665, ECO:0000269|PubMed:35085371}.
uniprot
proteins
mass_dalton
73185
uniprot
proteins
mutagenesis
MUTAGEN 598; /note="E->K: Abolishes interaction with dimethylarginine-containing protein motifs and reduces association with mRNA stress granules."; /evidence="ECO:0000269|PubMed:18632687"; MUTAGEN 638..644; /note="RPTQQFY->EPTQQFE: Loss of interaction with the EJC."; /evidence="ECO:0000269|PubMed:20930030
uniprot
proteins
post_translational_modification
PTM: Probably cleaved by enteroviral 2A proteinase. {ECO:0000269|PubMed:35085371}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15955813
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18632687
uniprot
proteins
pubmed
18664458
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20930030
uniprot
proteins
pubmed
21172665
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26700805
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
35085371
uniprot
proteins
sequence_length
651
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18632687}. Nucleus {ECO:0000269|PubMed:21172665}. Note=Predominantly cytoplasmic. Associated with actively translating polyribosomes. Component of stress granules (PubMed:18664458, PubMed:35085371). {ECO:0000269|PubMed:18664458, ECO:0000269|PubMed:35085371}.
uniprot
proteins