AGO4
entrez
192670
canonical
uniprot
Q9HCK5
canonical
ensembl
ENSG00000134698
resolver
ensp
ENSP00000362306
resolver
enst
ENST00000373210
resolver
genesymbol
AGO4
resolver
genesymbol_syn
EIF2C4
resolver
genesymbol_syn
KIAA1567
resolver
hgnc
HGNC:18424
resolver
uniprot
A7MD27
resolver
uniprot_entry
AGO4_HUMAN
resolver
uniprot_sec
A7MD27
resolver
amino_acid_sequence
MEALGPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA
uniprot
proteins
function
FUNCTION: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). {ECO:0000255|HAMAP-Rule:MF_03033, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:18552826, ECO:0000269|PubMed:18771919}.
uniprot
proteins
mass_dalton
97097
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated on surface-exposed lysines by a SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 during target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs). Ubiquitination by the SCF-like E3 ubiquitin-protein ligase complex containing ZSWIM8 leads to its subsequent degradation, thereby exposing miRNAs for degradation. ZSWIM8 recognizes and binds AGO4 when it is engaged with a TDMD target. {ECO:0000250|UniProtKB:Q9UKV8}.
uniprot
proteins
protein_family
Ago subfamily
uniprot
proteins
protein_family
Argonaute family
uniprot
proteins
pubmed
10997877
uniprot
proteins
pubmed
15260970
uniprot
proteins
pubmed
15337849
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15766526
uniprot
proteins
pubmed
16081698
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18552826
uniprot
proteins
pubmed
18771919
uniprot
proteins
pubmed
19167051
uniprot
proteins
sequence_length
861
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000255|HAMAP-Rule:MF_03033, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:19167051}.
uniprot
proteins