Cask
entrez
12361
canonical
uniprot
O70589
canonical
ensembl
ENSMUSG00000031012
resolver
ensp
ENSMUSP00000111096
resolver
ensp
ENSMUSP00000111098
resolver
ensp
ENSMUSP00000323715
resolver
ensp
ENSMUSP00000323716
resolver
ensp
ENSMUSP00000323718
resolver
ensp
ENSMUSP00000323719
resolver
ensp
ENSMUSP00000343792
resolver
genesymbol
Cask
resolver
genesymbol_syn
Lin-2
resolver
uniprot
A2ADP8
resolver
uniprot
A2ADP9
resolver
uniprot
A2ADQ4
resolver
uniprot
B9EJ23
resolver
uniprot
O70588
resolver
uniprot
Q3UW92
resolver
uniprot_entry
B9EJ23_MOUSE
resolver
uniprot_entry
CSKP_MOUSE
resolver
uniprot_sec
A2ADP8
resolver
uniprot_sec
A2ADP9
resolver
uniprot_sec
A2ADQ4
resolver
uniprot_sec
O70588
resolver
uniprot_sec
Q3UW92
resolver
activity_regulation
ACTIVITY REGULATION: Differs from archetypal CaMK members in that the kinase domain exhibits a constitutively active conformation and the autoinhibitory region does not engage in direct contact with the ATP-binding cleft, although it still binds Ca(2+)/CAM. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDVLQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (By similarity). Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156). {ECO:0000250|UniProtKB:O14936, ECO:0000269|PubMed:10749215, ECO:0000269|PubMed:10846156}.
uniprot
proteins
mass_dalton
105109
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily; MAGUK family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10749215
uniprot
proteins
pubmed
10846156
uniprot
proteins
pubmed
15066269
uniprot
proteins
pubmed
15863617
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22337881
uniprot
proteins
pubmed
25385611
uniprot
proteins
pubmed
9787075
uniprot
proteins
sequence_length
926
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q62915}. Cytoplasm {ECO:0000250|UniProtKB:Q62915}. Cell membrane {ECO:0000250|UniProtKB:Q62915}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62915}.
uniprot
proteins