Opn1sw
entrez
81644
canonical
uniprot
Q63652
canonical
ensembl
ENSRNOG00000006874
resolver
ensp
ENSRNOP00000009278
resolver
enst
ENSRNOT00000009278
resolver
genesymbol
Opn1sw
resolver
genesymbol_syn
Bcp
resolver
uniprot
G3V6V4
resolver
uniprot
O70363
resolver
uniprot_entry
G3V6V4_RAT
resolver
uniprot_entry
OPSB_RAT
resolver
uniprot_sec
O70363
resolver
amino_acid_sequence
MSGEDEFYLFQNISSVGPWDGPQYHIAPVWAFHLQAAFMGFVFFAGTPLNATVLVATLHYKKLRQPLNYILVNVSLGGFLFCIFSVFTVFIASCHGYFLFGRHVCALEAFLGSVAGLVTGWSLAFLAFERYLVICKPFGNIRFNSKHALTVVLITWTIGIGVSIPPFFGWSRFIPEGLQCSCGPDWYTVGTKYRSEHYTWFLFIFCFIIPLSLICFSYFQLLRTLRAVAAQQQESATTQKAEREVSHMVVVMVGSFCLCYVPYAALAMYMVNNRNHGLYLRLVTIPAFFSKSSCVYNPIIYCFMNKQFRACILEMVCRKPMTDESDMSGSQKTEVSTVSSSKVGPH
uniprot
proteins
function
FUNCTION: G protein-coupled photoreceptor that selectively activates transducin G alpha protein (G(t)) in response to short-wavelength (blue-violet) light, thereby stimulating the G(t)/transducin protein pathway (By similarity). This activation leads to increased cGMP phosphodiesterase activity, resulting in decreased intracellular cGMP and subsequent closure of cGMP-gated ion channels. The process is initiated when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers the G protein-mediated phototransduction cascade (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of cone photoreceptor function (By similarity). Involved in ensuring the correct abundance and localization of retinal membrane proteins (By similarity). Mediates visual perception of blue light (By similarity). May contribute to increased spectral sensitivity under dim light conditions (By similarity). Is not UV-sensitive (By similarity). {ECO:0000250|UniProtKB:D5H3X0, ECO:0000250|UniProtKB:P03999, ECO:0000250|UniProtKB:P04000, ECO:0000250|UniProtKB:P51491}.
uniprot
proteins
mass_dalton
39062
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.; PTM: Contains one retinal chromophore covalently bound to a lysine residue via a Schiff base. Upon light absorption, the bound 11-cis-retinal isomerizes to all-trans-retinal. Following activation, the covalently bound all-trans-retinal is released through hydrolysis of the Schiff base, and OPN1 is regenerated by binding a new 11-cis-retinal molecule. {ECO:0000250|UniProtKB:P03999}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Opsin subfamily
uniprot
proteins
pubmed
9147475
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P03999}; Multi-pass membrane protein {ECO:0000255}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P51491}. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P51491}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P03999}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..56; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 69..94; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 109..128; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 148..171; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 198..225; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 248..271; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 280..304; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins