Akap8
entrez
116633
canonical
uniprot
Q63014
canonical
ensembl
ENSRNOG00000006559
resolver
ensembl
ENSRNOG00055032384
resolver
ensembl
ENSRNOG00060029491
resolver
ensembl
ENSRNOG00065018925
resolver
ensp
ENSRNOP00000008827
resolver
ensp
ENSRNOP00055046076
resolver
ensp
ENSRNOP00060042636
resolver
ensp
ENSRNOP00065025359
resolver
enst
ENSRNOT00000008827
resolver
enst
ENSRNOT00055055919
resolver
enst
ENSRNOT00060051249
resolver
enst
ENSRNOT00065031798
resolver
genesymbol
Akap8
resolver
genesymbol_syn
Akap95
resolver
uniprot
B2GV93
resolver
uniprot_entry
AKAP8_RAT
resolver
uniprot_entry
B2GV93_RAT
resolver
amino_acid_sequence
MEQSYGGYGAWSAGPANTQGTYGSGVASWQGYENYSYYNAQNTSVPTGTPYSYGPASWEATKASDGGLAAGSSAMHVASFAPEPCTDNSDSLIAKINQRLDMLSKEGGRGGISSGGEGMQDRDSSFRFQPYESYDSRPCMPEHTPYRPSYSYDYDFDLGTDRNGSFGGTFNDCRDPTPERGALDGFLRGRGQGRFQDRSNSSTFIRSDPFMPPSASSEPLSTTWSELNYMGGRGLGGPSTNRPPPSLFSQSMAPDYSMMGMQGVGGFGGTMPYGCGRSQTRIRDWPRRRGFERFGPDNMGRKRKPFPLYEEPDAKLARADSEGDLSENDDGAGDLRSGDEEFRGEDDLCDSRKQRGEKEDEDEDVKKRREKQRRRDRMRDRAADRIQFACSVCKFRSFEDEEIQKHLQSKFHKETLRFISTKLPDKTVEFLQEYIINRNKKIEKRRQELLEKESPKPKPDPFKGIGQEHFFKRIEAAHCLACDMLIPAQHQLLQRHLHSVDHNHNRRLAAEQFKKTSLHVAKSVLNNKHIVKMLEKYLKGEDPFVNETADLETEGDENLGEEKETPEEVAAEVLAEVITAAVKAVEGDGEPAAEHSDVLAEVEGPVDTAEAGSDSHTGKLLEEQTCETASETRNMEDMARGEAAEARNEAAVPAAAAGSPVPVIAIPGILEDELEQTDAEAKDTPTE
uniprot
proteins
function
FUNCTION: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:8125992). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L. Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation. May be involved in regulation of DNA replication by acting as scaffold for MCM2. Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation. May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells. May act as a carrier protein of GJA1 for its transport to the nucleus. May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions. Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). {ECO:0000250|UniProtKB:O43823, ECO:0000250|UniProtKB:Q9DBR0, ECO:0000269|PubMed:8125992}.
uniprot
proteins
mass_dalton
76162
uniprot
proteins
mutagenesis
MUTAGEN 302..303; /note="KR->EQ: Impairs nuclear localization."; /evidence="ECO:0000269|PubMed:11279182
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues probably by SRC subfamily protein kinases; multiple phosphorylation is leading to dissociation from nuclear structures implicated in chromatin structural changes. {ECO:0000250|UniProtKB:O43823}.
uniprot
proteins
protein_family
AKAP95 family
uniprot
proteins
pubmed
11279182
uniprot
proteins
pubmed
16721056
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8125992
uniprot
proteins
sequence_length
687
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:11279182, ECO:0000269|PubMed:8125992}. Nucleus, nucleolus {ECO:0000250|UniProtKB:O43823}. Cytoplasm {ECO:0000250|UniProtKB:Q9DBR0}. Note=Associated with the nuclear matrix. Redistributed and detached from condensed chromatin during mitosis. Exhibits partial localization to the nucleolus in interphase, possibly to the fibrillary center and/or to the dense fibrillary component (By similarity). {ECO:0000250|UniProtKB:O43823}.
uniprot
proteins