Runx2
entrez
12393
canonical
uniprot
Q08775
canonical
ensembl
ENSMUSG00000039153
resolver
ensp
ENSMUSP00000109201
resolver
ensp
ENSMUSP00000109202
resolver
ensp
ENSMUSP00000123707
resolver
ensp
ENSMUSP00000123743
resolver
ensp
ENSMUSP00000124918
resolver
enst
ENSMUST00000113572
resolver
enst
ENSMUST00000162878
resolver
genesymbol
Runx2
resolver
genesymbol_syn
Aml3
resolver
genesymbol_syn
Cbfa-1
resolver
genesymbol_syn
Cbfa1
resolver
genesymbol_syn
Osf2
resolver
genesymbol_syn
Pebp2a
resolver
uniprot
E0CZ12
resolver
uniprot
F8WHN7
resolver
uniprot
O35183
resolver
uniprot
Q08776
resolver
uniprot
Q9JLN0
resolver
uniprot
Q9QUQ6
resolver
uniprot
Q9QY29
resolver
uniprot
Q9R0U4
resolver
uniprot
Q9Z2J7
resolver
uniprot
Q9Z2T9
resolver
uniprot_entry
E0CZ12_MOUSE
resolver
uniprot_entry
F8WHN7_MOUSE
resolver
uniprot_entry
Q9Z2T9_MOUSE
resolver
uniprot_entry
RUNX2_MOUSE
resolver
uniprot_sec
O35183
resolver
uniprot_sec
Q08776
resolver
uniprot_sec
Q9JLN0
resolver
uniprot_sec
Q9QUQ6
resolver
uniprot_sec
Q9QY29
resolver
uniprot_sec
Q9R0U4
resolver
uniprot_sec
Q9Z2J7
resolver
amino_acid_sequence
MLHSPHKQPQNHKCGANFLQEDCKKALAFKWLISAGHYQPPRPTESVSALTTVHAGIFKAASSIYNRGHKFYLEKKGGTMASNSLFSAVTPCQQSFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFSDRLSDLGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAITDVPRRISDDDTATSDFCLWPSSLSKKSQAGASELGPFSDPRQFPSISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHTYLPPPYPGSSQSQSGPFQTSSTPYLYYGTSSASYQFPMVPGGDRSPSRMVPPCTTTSNGSTLLNPNLPNQNDGVDADGSHSSSPTVLNSSGRMDESVWRPY
uniprot
proteins
function
FUNCTION: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation (By similarity). In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). {ECO:0000250, ECO:0000269|PubMed:20484411, ECO:0000269|PubMed:9182763}.
uniprot
proteins
mass_dalton
66205
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; probably by MAP kinases (MAPK). Phosphorylation by HIPK3 is required for the SPEN/MINT and FGF2 transactivation during osteoblastic differentiation. Phosphorylation at Ser-537 by CDK1 promotes endothelial cell proliferation required for tumor angiogenesis probably by facilitating cell cycle progression (By similarity). {ECO:0000250}.; PTM: Ubiquitinated by the complex made of the adapter SMAD6 and the E3 ligase SMURF1, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q13950}.
uniprot
proteins
pubmed
10524201
uniprot
proteins
pubmed
10660618
uniprot
proteins
pubmed
15557274
uniprot
proteins
pubmed
16728642
uniprot
proteins
pubmed
16751105
uniprot
proteins
pubmed
17960593
uniprot
proteins
pubmed
20484411
uniprot
proteins
pubmed
21239498
uniprot
proteins
pubmed
21471200
uniprot
proteins
pubmed
24028588
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
29148101
uniprot
proteins
pubmed
35922041
uniprot
proteins
pubmed
8341710
uniprot
proteins
pubmed
8386878
uniprot
proteins
pubmed
9182762
uniprot
proteins
pubmed
9182763
uniprot
proteins
pubmed
9238031
uniprot
proteins
pubmed
9651525
uniprot
proteins
sequence_length
607
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35922041}. Cytoplasm {ECO:0000269|PubMed:35922041}.
uniprot
proteins