Rab1A
entrez
81754
canonical
uniprot
Q6NYB7
canonical
ensembl
ENSRNOG00000004992
resolver
ensembl
ENSRNOG00055007725
resolver
ensembl
ENSRNOG00060014698
resolver
ensembl
ENSRNOG00065006088
resolver
ensp
ENSRNOP00000073493
resolver
ensp
ENSRNOP00000107962
resolver
ensp
ENSRNOP00055010451
resolver
ensp
ENSRNOP00060020245
resolver
ensp
ENSRNOP00065006703
resolver
enst
ENSRNOT00000167788
resolver
enst
ENSRNOT00055013072
resolver
enst
ENSRNOT00060025394
resolver
enst
ENSRNOT00065009329
resolver
genesymbol
Rab1A
resolver
genesymbol
Rab1a
resolver
genesymbol_syn
Rab1
resolver
uniprot
A0ABK0LRS9
resolver
uniprot
P05711
resolver
uniprot_entry
A0ABK0LRS9_RAT
resolver
uniprot_entry
RAB1A_RAT
resolver
uniprot_sec
P05711
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:P62820}.
uniprot
proteins
amino_acid_sequence
MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTPVKQSGGGCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21303926). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21303926). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (PubMed:21303926). Required to modulate the compacted morphology of the Golgi. Regulates the level of CASR present at the cell membrane (By similarity). Plays a role in cell adhesion and cell migration, via its role in protein trafficking (By similarity). Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity). {ECO:0000250|UniProtKB:P62820, ECO:0000250|UniProtKB:P62821, ECO:0000269|PubMed:21303926}.
uniprot
proteins
mass_dalton
22678
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK1 kinase during mitosis. {ECO:0000250|UniProtKB:P62820}.; PTM: Ubiquitinated via 'Lys-11'-linked ubiquitination on Lys-49 and Lys-61; impairing the recruitment of guanosine diphosphate (GDP) dissociation inhibitor 1/GDI1. {ECO:0000250|UniProtKB:P51153}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19423663
uniprot
proteins
pubmed
21303926
uniprot
proteins
pubmed
3317403
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:P62820}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P62820}. Early endosome {ECO:0000269|PubMed:21303926}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62820}. Membrane {ECO:0000250|UniProtKB:P62820}. Melanosome {ECO:0000250|UniProtKB:P62821}. Note=Alternates between membrane-associated and cytosolic forms. {ECO:0000250|UniProtKB:P62820}.
uniprot
proteins