TMIGD2
entrez
126259
canonical
uniprot
Q96BF3
canonical
ensembl
ENSG00000167664
resolver
ensp
ENSP00000301272
resolver
ensp
ENSP00000470494
resolver
ensp
ENSP00000470561
resolver
enst
ENST00000600114
resolver
genesymbol
TMIGD2
resolver
genesymbol_syn
CD28H
resolver
genesymbol_syn
IGPR1
resolver
hgnc
HGNC:28324
resolver
uniprot
A0A0B4J2A9
resolver
uniprot
Q6UW59
resolver
uniprot_entry
A0A0B4J2A9_HUMAN
resolver
uniprot_entry
TMIG2_HUMAN
resolver
uniprot_sec
Q6UW59
resolver
amino_acid_sequence
MGSPGMVLGLLVQIWALQEASSLSVQQGPNLLQVRQGSQATLVCQVDQATAWERLRVKWTKDGAILCQPYITNGSLSLGVCGPQGRLSWQAPSHLTLQLDPVSLNHSGAYVCWAAVEIPELEEAEGNITRLFVDPDDPTQNRNRIASFPGFLFVLLGVGSMGVAAIVWGAWFWGRRSCQQRDSGNSPGNAFYSNVLYRPRGAPKKSEDCSGEGKDQRGQSIYSTSFPQPAPRQPHLASRPCPSPRPCPSPRPGHPVSMVRVSPRPSPTQQPRPKGFPKVGEE
uniprot
proteins
function
FUNCTION: Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:22419821, ECO:0000269|PubMed:23784006}.
uniprot
proteins
mass_dalton
30675
uniprot
proteins
mutagenesis
MUTAGEN 192; /note="Y->F: Partial loss of phosphorylation; when associated with F-197. Complete loss of phosphorylation; when associated with F-222."; /evidence="ECO:0000269|PubMed:23784006"; MUTAGEN 197; /note="Y->F: Partial loss of phosphorylation; when associated with F-192 or with F-222."; /evidence="ECO:0000269|PubMed:23784006"; MUTAGEN 222; /note="Y->F: Partial loss of phosphorylation; when tested individually or when associated with F-197. Complete loss of phosphorylation; when associated with F-192."; /evidence="ECO:0000269|PubMed:23784006
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:22419821}.
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
22419821
uniprot
proteins
pubmed
23784006
uniprot
proteins
sequence_length
282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22419821}; Single-pass type I membrane protein {ECO:0000269|PubMed:22419821}.
uniprot
proteins
transmembrane_region
TRANSMEM 151..171; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins