Abhd5
entrez
67469
canonical
uniprot
Q9DBL9
canonical
ensembl
ENSMUSG00000032540
resolver
ensp
ENSMUSP00000107123
resolver
ensp
ENSMUSP00000122274
resolver
genesymbol
Abhd5
resolver
uniprot
Q9CTY3
resolver
uniprot_entry
ABHD5_MOUSE
resolver
uniprot_sec
Q9CTY3
resolver
activity_regulation
ACTIVITY REGULATION: Acyltransferase activity is inhibited by detergents such as Triton X-100 and 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS). Acyltransferase activity is inhibited by the presence of magnesium and calcium. {ECO:0000269|PubMed:19801371}.
uniprot
proteins
amino_acid_sequence
MKAMAAEEEVDSADAGGGSGWLTGWLPTWCPTSTSHLKEAEEKMLKCVPCTYKKEPVRISNGNRIWTLMFSHNISSKTPLVLLHGFGGGLGLWALNFEDLSTDRPVYAFDLLGFGRSSRPRFDSDAEEVENQFVESIEEWRCALRLDKMILLGHNLGGFLAAAYSLKYPSRVSHLILVEPWGFPERPDLADQERPIPVWIRALGAALTPFNPLAGLRIAGPFGLSLVQRLRPDFKRKYSSMFEDDTVTEYIYHCNVQTPSGETAFKNMTIPYGWAKRPMLQRIGGLHPDIPVSVIFGARSCIDGNSGTSIQSLRPKSYVKTIAILGAGHYVYADQPEEFNQKVKEICHTVD
uniprot
proteins
ec_number
2.3.1.51
uniprot
proteins
function
FUNCTION: Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid (PubMed:19801371). Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor (PubMed:19801371). Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (PubMed:19801371). Functions in phosphatidic acid biosynthesis (By similarity). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289). Involved in keratinocyte differentiation (By similarity). Regulates lipid droplet fusion (PubMed:26083785). {ECO:0000250|UniProtKB:Q8WTS1, ECO:0000269|PubMed:16679289, ECO:0000269|PubMed:19801371, ECO:0000269|PubMed:26083785}.
uniprot
proteins
mass_dalton
39155
uniprot
proteins
protein_family
ABHD4/ABHD5 subfamily
uniprot
proteins
protein_family
Peptidase S33 family
uniprot
proteins
pubmed
15292255
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16679289
uniprot
proteins
pubmed
18606822
uniprot
proteins
pubmed
18832586
uniprot
proteins
pubmed
19064991
uniprot
proteins
pubmed
19801371
uniprot
proteins
pubmed
21148142
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26083785
uniprot
proteins
pubmed
28002418
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Lipid droplet {ECO:0000269|PubMed:18606822}. Cytoplasm, cytosol {ECO:0000269|PubMed:18606822}. Note=Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA.
uniprot
proteins