Mrs2
entrez
380836
canonical
uniprot
Q5NCE8
canonical
ensembl
ENSMUSG00000021339
resolver
ensp
ENSMUSP00000021772
resolver
ensp
ENSMUSP00000163355
resolver
enst
ENSMUST00000021772
resolver
genesymbol
Mrs2
resolver
genesymbol_syn
Gm902
resolver
genesymbol_syn
Mrs2l
resolver
uniprot_entry
MRS2_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: May be regulated by calcium ions. {ECO:0000250|UniProtKB:Q9HD23}.
uniprot
proteins
amino_acid_sequence
MECLRCLPGLLPRAAQPRRALWTAVARLSLAACGGRATPLRSRSPKASSTARAAGDVLRFRTSDASQATLASVAQVFAVTKFDKEGNVTSFERKKTELYHELALQARDLRFQHVMSITTRNNRIIMRMEYLKAVITPECLLILDYRNLNLEHWLFRELPSQLAGEGQLVTYPLPFEFRAIEALLQYWISTLRGRLSVLQPLILETLDALVDPKHSSVDRSKLHVLLQNGKSLSELETDIKIFKESILELLDEEEMLEELCLTKWSDPHVFEKSSTGIDHAEEMELLLENYYRLAEDLSNEARELRVLIDDSQSIIFINLDSHRNVMMRLNLQLTMGTFSLSLFGLMGVAFGMNLESSLEEDHRVFWLVTGIMFMGSGLIWRRLLSFLGRQLEAPVPPVMTSLPKKTLLANRRMDVKNSLRPEGLGASRTILASR
uniprot
proteins
function
FUNCTION: Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix and regulates magnesium metabolism (By similarity). Also permeable to calcium, sodium and potassium ions (By similarity). Required for normal expression of the mitochondrial respiratory complex I subunits (By similarity). May play a role in maintaining the inner mitochondrial membrane potential (By similarity). {ECO:0000250|UniProtKB:Q9HD23}.
uniprot
proteins
mass_dalton
49299
uniprot
proteins
protein_family
CorA metal ion transporter (MIT) (TC 1.A.35) family
uniprot
proteins
pubmed
11401429
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9HD23}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9HD23}.
uniprot
proteins
transmembrane_region
TRANSMEM 331..350; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9HD23"; TRANSMEM 362..392; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9HD23
uniprot
proteins