Srcin1
entrez
56029
canonical
uniprot
Q9QXY2
canonical
ensembl
ENSRNOG00000011475
resolver
ensp
ENSRNOP00000080321
resolver
ensp
ENSRNOP00000083677
resolver
ensp
ENSRNOP00000095793
resolver
ensp
ENSRNOP00000099638
resolver
ensp
ENSRNOP00000102162
resolver
ensp
ENSRNOP00000105332
resolver
genesymbol
Srcin1
resolver
genesymbol_syn
P140
resolver
genesymbol_syn
Snip
resolver
uniprot
Q9QXY3
resolver
uniprot_entry
SRCN1_RAT
resolver
uniprot_sec
Q9QXY3
resolver
amino_acid_sequence
MQPWQCLRRFALAWWERTAEGRARSPREEVGPRDPGGRGEPDPERSSPPMLSADDAEYPREYRTLGGGGSGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPASHLASSSPPPGLPSGLPSGLPSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPTSQGVSPSPSAILERRDVKPDEDLAGKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAGAGGPLYGDGYGFRLPPSSPQKLADVSAPSGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKARSTGASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPVCGSGSRSSGATPVSGPPPPAVSSTPAGQPTAVSRLQMQMHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVAHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRVVTDTLAQIRRQVDEGVWPPPNNLLNQSPKKVAAETDFSKGLDFEIPPPSPPLNLHELSGPAEGTPLTPKSGNPTKGLDAPSKRNMDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKTHPGPTPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSVFIKKAESEELEIQKPQVKLRRAVSEVVRPASTPPIMASAIKDEDDEERIIAELESGGGSVPPMKVVTPGASRLKAAQGPAGSPDKGKHGKQRTEYMRIQAQQQVRVGYQAPRPLEGCTPRLCYMPLS
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. {ECO:0000269|PubMed:10625663, ECO:0000269|PubMed:19146815}.
uniprot
proteins
mass_dalton
129744
uniprot
proteins
post_translational_modification
PTM: Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands. {ECO:0000250|UniProtKB:Q9C0H9}.
uniprot
proteins
protein_family
SRCIN1 family
uniprot
proteins
pubmed
10625663
uniprot
proteins
pubmed
18662323
uniprot
proteins
pubmed
19146815
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1197
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22673903}. Cell projection, axon. Cell projection, dendrite {ECO:0000269|PubMed:19146815}. Presynapse {ECO:0000269|PubMed:18662323}. Postsynapse {ECO:0000269|PubMed:18662323, ECO:0000269|PubMed:19146815}. Postsynaptic density {ECO:0000269|PubMed:19146815}. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions. {ECO:0000269|PubMed:18662323, ECO:0000269|PubMed:19146815, ECO:0000269|PubMed:22673903}.
uniprot
proteins