Cacng2
entrez
12300
canonical
uniprot
O88602
canonical
ensembl
ENSMUSG00000019146
resolver
ensp
ENSMUSP00000019290
resolver
enst
ENSMUST00000019290
resolver
genesymbol
Cacng2
resolver
genesymbol_syn
Stg
resolver
uniprot
Q3ZB20
resolver
uniprot_entry
CCG2_MOUSE
resolver
uniprot_entry
Q3ZB20_MOUSE
resolver
amino_acid_sequence
MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGVKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKDSKDSLHANTANRRTTPV
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Cacng2 cause the stargazer (stg) phenotype. Stg mice have spike-wave seizures characteristic of absence epilepsy, with accompanying defects in the cerebellum and inner ear. {ECO:0000269|PubMed:9697694}.
uniprot
proteins
function
FUNCTION: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). {ECO:0000250|UniProtKB:Q71RJ2, ECO:0000250|UniProtKB:Q9Y698}.
uniprot
proteins
mass_dalton
35895
uniprot
proteins
mutagenesis
MUTAGEN 321; /note="T->A: Abolishes phosphorylation."; /evidence="ECO:0000269|PubMed:11805122"; MUTAGEN 321; /note="T->D,E: No interaction with DLG1 and DLG4."; /evidence="ECO:0000269|PubMed:11805122"; MUTAGEN 323; /note="V->A: No interaction with DLG1 and DLG4."; /evidence="ECO:0000269|PubMed:11805122
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-321 by PKA impairs interaction with DLG1 and DLG4. {ECO:0000269|PubMed:11805122}.
uniprot
proteins
protein_family
CACNG subfamily
uniprot
proteins
protein_family
PMP-22/EMP/MP20 family
uniprot
proteins
pubmed
11805122
uniprot
proteins
pubmed
15136571
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9697694
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Synapse, synaptosome {ECO:0000250|UniProtKB:Q71RJ2}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 134..154; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 182..202; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins