Tm7sf3
entrez
67623
canonical
uniprot
Q9CRG1
canonical
ensembl
ENSMUSG00000040234
resolver
ensp
ENSMUSP00000045650
resolver
enst
ENSMUST00000037709
resolver
genesymbol
Tm7sf3
resolver
uniprot
A0A0R4J0K4
resolver
uniprot
Q3TBQ2
resolver
uniprot
Q3U3Q6
resolver
uniprot
Q4F873
resolver
uniprot
Q6PES5
resolver
uniprot_entry
A0A0R4J0K4_MOUSE
resolver
uniprot_entry
TM7S3_MOUSE
resolver
uniprot_sec
Q3TBQ2
resolver
uniprot_sec
Q3U3Q6
resolver
uniprot_sec
Q4F873
resolver
uniprot_sec
Q6PES5
resolver
amino_acid_sequence
MWRLRLLVLAVLAAGSAEAQANSSDGFLEFSVGKFTYFVLSKSSPQEAVLRHISSNVTFLLFQIHSQYQNTTVSFTKTLLPSTSGTGNDRGLVFILRPEQAVCTWYLETGDTKPVQSVALTLSYSERDPIPGGCNLEFDLDIDPNLYLDYNFFETTIKFAPANIGYARATEPPPCDVSTSRESRWRLRYDVYQYFLPEGDLTEASLLHHLQRMAQVAQVKASAIKVATLTADDKTAVSFSSLPGQGVIYNVIVWDPSLNTSAAYVPVHTYACSFESVDGNCASPGRVSTKVFSTLFALLGLFVCFFGHRFWKTDLFFVGFIFLGFFFYILITRLTPLQYDVRLALTAVAGSFGGLLLVASWWRFGILTLCMLCVGLVLGFLVSSGTFFTPLGNLNVFHDDGVFWVTFSCIALLVPVIFMGCLRILNILACGVVGSYSVVLAVNSYMFTSLSYITLNVLRRALNTDFRGAFIRVPFQTNDYIILAVWGMLAVSGITLQIRRERGQPPFPPHPYKLWKQERERRVTNILDPSHHIPPLRERLYGRVARIKELFQKEQPAGERTPLLL
uniprot
proteins
function
FUNCTION: Involved in the inhibition of cytokine-induced death of pancreatic beta cells (PubMed:21853325). Involved in the promotion of insulin secretion from pancreatic beta cells (By similarity). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623). {ECO:0000250|UniProtKB:Q9NS93, ECO:0000269|PubMed:21853325, ECO:0000269|PubMed:27740623}.
uniprot
proteins
mass_dalton
63251
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21853325
uniprot
proteins
pubmed
27740623
uniprot
proteins
sequence_length
565
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NS93}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 287..307; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 315..335; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 341..361; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 364..384; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 402..422; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 427..447; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 478..498; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins