Aco1
entrez
11428
canonical
uniprot
P28271
canonical
ensembl
ENSMUSG00000028405
resolver
ensp
ENSMUSP00000100038
resolver
ensp
ENSMUSP00000243137
resolver
enst
ENSMUST00000102973
resolver
genesymbol
Aco1
resolver
genesymbol_syn
Ireb1
resolver
genesymbol_syn
Irebp
resolver
uniprot
Q3TQ15
resolver
uniprot
Q99K54
resolver
uniprot_entry
ACOHC_MOUSE
resolver
uniprot_sec
Q3TQ15
resolver
uniprot_sec
Q99K54
resolver
amino_acid_sequence
MKNPFAHLAEPLDAAQPGKRFFNLNKLEDSRYGRLPFSIRVLLEAAVRNCDEFLVKKNDIENILNWNVMQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGNPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNKERFEFLKWGSQAFCNMRIIPPGSGIIHQVNLEYLARVVFDQDGCYYPDSLVGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPQVIGYKLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSIAYLLQTGREEDKVKHIQKYLQAVGMFRDFNDTSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSEMKKDFESCLGAKQGFKGFQVAPDRHNDRKTFLYSNSEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVEAGLSVKPYIKTSLSPGSGVVTYYLRESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTVRIDFEKEPLGVNAQGRQVFLKDIWPTRDEIQAVERQHVIPGMFKEVYQKIETVNKSWNALAAPSEKLYAWNPKSTYIKSPPFFESLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAIMARGTFANIRLLNKFLNKQAPQTVHLPSGETLDVFDAAERYQQAGLPLIVLAGKEYGSGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGETADSLGLTGRERYTINIPEDLKPRMTVQIKLDTGKTFQAVMRFDTDVELTYFHNGGILNYMIRKMAQ
uniprot
proteins
ec_number
4.2.1.3
uniprot
proteins
function
FUNCTION: Bifunctional iron sensor that switches between 2 activities depending on iron availability (By similarity). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:1956798). {ECO:0000250|UniProtKB:P21399, ECO:0000269|PubMed:1956798}.; FUNCTION: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P21399}.
uniprot
proteins
mass_dalton
98126
uniprot
proteins
protein_family
Aconitase/IPM isomerase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
1956798
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
889
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P21399}.
uniprot
proteins