ERVMER34-1
entrez
100288413
canonical
uniprot
Q9H9K5
canonical
ensembl
ENSG00000226887
resolver
ensp
ENSP00000460255
resolver
ensp
ENSP00000460602
resolver
ensp
ENSP00000568652
resolver
ensp
ENSP00000568653
resolver
ensp
ENSP00000568654
resolver
ensp
ENSP00000585290
resolver
ensp
ENSP00000585291
resolver
ensp
ENSP00000585292
resolver
ensp
ENSP00000585293
resolver
ensp
ENSP00000585294
resolver
ensp
ENSP00000585295
resolver
ensp
ENSP00000585296
resolver
ensp
ENSP00000585297
resolver
ensp
ENSP00000614667
resolver
ensp
ENSP00000614668
resolver
enst
ENST00000440542
resolver
enst
ENST00000443173
resolver
enst
ENST00000898593
resolver
enst
ENST00000898594
resolver
enst
ENST00000898595
resolver
enst
ENST00000915231
resolver
enst
ENST00000915232
resolver
enst
ENST00000915233
resolver
enst
ENST00000915234
resolver
enst
ENST00000915235
resolver
enst
ENST00000915236
resolver
enst
ENST00000915237
resolver
enst
ENST00000915238
resolver
enst
ENST00000944608
resolver
enst
ENST00000944609
resolver
genesymbol
ERVMER34-1
resolver
genesymbol_syn
HEMO
resolver
hgnc
HGNC:42970
resolver
uniprot
B3KTB4
resolver
uniprot
Q0P5R3
resolver
uniprot
Q6NWN0
resolver
uniprot_entry
MER34_HUMAN
resolver
uniprot_sec
B3KTB4
resolver
uniprot_sec
Q0P5R3
resolver
uniprot_sec
Q6NWN0
resolver
amino_acid_sequence
MGSLSNYALLQLTLTAFLTILVQPQHLLAPVFRTLSILTNQSNCWLCEHLDNAEQPELVFVPASASTWWTYSGQWMYERVWYPQAEVQNHSTSSYRKVTWHWEASMEAQGLSFAQVRLLEGNFSLCVENKNGSGPFLGNIPKQYCNQILWFDSTDGTFMPSIDVTNESRNDDDDTSVCLGTRQCSWFAGCTNRTWNSSAVPLIGLPNTQDYKWVDRNSGLTWSGNDTCLYSCQNQTKGLLYQLFRNLFCSYGLTEAHGKWRCADASITNDKGHDGHRTPTWWLTGSNLTLSVNNSGLFFLCGNGVYKGFPPKWSGRCGLGYLVPSLTRYLTLNASQITNLRSFIHKVTPHRCTQGDTDNPPLYCNPKDNSTIRALFPSLGTYDLEKAILNISKAMEQEFSATKQTLEAHQSKVSSLASASRKDHVLDIPTTQRQTACGTVGKQCCLYINYSEEIKSNIQRLHEASENLKNVPLLDWQGIFAKVGDWFRSWGYVLLIVLFCLFIFVLIYVRVFRKSRRSLNSQPLNLALSPQQSAQLLVSETSCQVSNRAMKGLTTHQYDTSLL
uniprot
proteins
function
FUNCTION: Endogenous envelope proteins originate from retroviral envelope proteins, which mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. {ECO:0000305}.
uniprot
proteins
mass_dalton
63547
uniprot
proteins
mutagenesis
MUTAGEN 352..355; /note="CTQG->RTKR: Introduction of a furin cleavage site, promoting proteolytic cleavage of the protein by furin and release in the extracellular medium."; /evidence="ECO:0000269|PubMed:28739914"; MUTAGEN 433..563; /note="Missing: Promotes release in the extracellular medium."; /evidence="ECO:0000269|PubMed:28739914"; MUTAGEN 472..563; /note="Missing: Promotes release in the extracellular medium."; /evidence="ECO:0000269|PubMed:28739914"; MUTAGEN 489..563; /note="Missing: Promotes release in the extracellular medium."; /evidence="ECO:0000269|PubMed:28739914
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:28739914}.; PTM: [Endogenous retroviral envelope protein HEMO]: Cleaved by some metalloproteinase at 432-Gln-Arg-433 (mainly) or 433-Arg-Gln-434, leading to release the secreted form (Endogenous retroviral envelope protein HEMO, secreted form) in the extracellular medium. {ECO:0000269|PubMed:28739914}.
uniprot
proteins
protein_family
Gamma type-C retroviral envelope protein family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
28739914
uniprot
proteins
sequence_length
563
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Endogenous retroviral envelope protein HEMO]: Cell membrane {ECO:0000269|PubMed:28739914}; Single-pass type I membrane protein {ECO:0000255}. Note=This uncleaved form present at the cell surface represents the major form (PubMed:28739914). {ECO:0000269|PubMed:28739914}.; SUBCELLULAR LOCATION: [Endogenous retroviral envelope protein HEMO, secreted form]: Secreted {ECO:0000269|PubMed:28739914}. Note=This secreted form, which is released in the extracellular medium following cleavage, constitutes a minor form (PubMed:28739914). {ECO:0000269|PubMed:28739914}.
uniprot
proteins
transmembrane_region
TRANSMEM 489..509; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins