Gsdmc3
entrez
270328
canonical
uniprot
Q8CB12
canonical
ensembl
ENSMUSG00000055827
resolver
ensp
ENSMUSP00000087339
resolver
ensp
ENSMUSP00000139472
resolver
ensp
ENSMUSP00000140272
resolver
enst
ENSMUST00000089894
resolver
enst
ENSMUST00000185526
resolver
enst
ENSMUST00000190682
resolver
genesymbol
Gsdmc3
resolver
uniprot
E9QJY6
resolver
uniprot_entry
GSDC3_MOUSE
resolver
uniprot_sec
E9QJY6
resolver
activity_regulation
ACTIVITY REGULATION: [Gasdermin-C3]: The full-length protein before cleavage is inactive: intramolecular interactions between N- and C-terminal domains mediate autoinhibition in the absence of activation signal (By similarity). The intrinsic pyroptosis-inducing activity is carried by the released N-terminal moiety (Gasdermin-C3, N-terminal) following cleavage by caspase CASP8 (By similarity). {ECO:0000250|UniProtKB:Q9BYG8}.
uniprot
proteins
amino_acid_sequence
MGYSFDRASKDVVKKLQGRDLRPVECLSDATKFRLFHILQETPRSGWETEDIPVGFTLLDLLEPNFPVPEPEVSAPKPFIHVQSTDLEANLNVADIARGGVGYVGYGGYNIEVQSTSIPNPKLEILQNRKLLDKLPTFMKFCRMERKNLYVVTEAYEVSKDTMLTGLSSVNLLVKGFFKQLFKVRGKAGRSEKYSIPIPKGSVLAYKKQQLVIENNTCVILPSATKKKMTFPGTPKYASASEPTEIYRTELQGLWINDIEPIGRIQEPAHLDFKCLQYEVSEQTRLLPELSKDVQEVVLSSFLSMLYEGDRNVLHDLMKMLELSQLGHMDGPGGKILDELRKDSSNPCVDLKDLILYLLQALMVLSDSQLNLLARSVEMRLLPHQVELVTSILQPNFKYPWNIPFTVQPQLLAPLQGEGLAITYELLEECGLKMELNNPRSTWDLEAKMPLSALYGSLSFLQQLQKANSSFKPSLRPGYI
uniprot
proteins
function
FUNCTION: [Gasdermin-C3]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C3, N-terminal) binds to membranes and forms pores, triggering pyroptosis. {ECO:0000250|UniProtKB:Q9BYG8}.; FUNCTION: [Gasdermin-C3, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis. Produced by the cleavage of gasdermin-C3 by caspase CASP8 in response to death signals (By similarity). After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (By similarity). {ECO:0000250|UniProtKB:Q9BYG8}.
uniprot
proteins
mass_dalton
54188
uniprot
proteins
post_translational_modification
PTM: Cleavage by CASP8 relieves autoinhibition by releasing the N-terminal moiety (Gasdermin-C3, N-terminal) that initiates pyroptosis. {ECO:0000250|UniProtKB:Q9BYG8}.; PTM: Palmitoylated. {ECO:0000250|UniProtKB:Q9BYG8}.
uniprot
proteins
protein_family
Gasdermin family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17350798
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Gasdermin-C3]: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BYG8}.; SUBCELLULAR LOCATION: [Gasdermin-C3, N-terminal]: Cell membrane {ECO:0000250|UniProtKB:Q5Y4Y6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}.
uniprot
proteins