THPO
entrez
7066
canonical
uniprot
P40225
canonical
ensembl
ENSG00000090534
resolver
ensp
ENSP00000410763
resolver
ensp
ENSP00000411704
resolver
ensp
ENSP00000494281
resolver
ensp
ENSP00000494504
resolver
ensp
ENSP00000497233
resolver
ensp
ENSP00000497904
resolver
ensp
ENSP00000546598
resolver
enst
ENST00000421442
resolver
enst
ENST00000645603
resolver
enst
ENST00000649095
resolver
enst
ENST00000650229
resolver
genesymbol
THPO
resolver
genesymbol_syn
MGDF
resolver
hgnc
HGNC:11795
resolver
uniprot
A0A3B3ISB0
resolver
uniprot
A0A3B3ITS0
resolver
uniprot
A1L3Y0
resolver
uniprot
B7ZLR8
resolver
uniprot
B9EGA8
resolver
uniprot
F8W6L1
resolver
uniprot
Q13020
resolver
uniprot
Q15790
resolver
uniprot
Q15791
resolver
uniprot
Q15792
resolver
uniprot
Q5FBX8
resolver
uniprot_entry
A0A3B3ISB0_HUMAN
resolver
uniprot_entry
A0A3B3ITS0_HUMAN
resolver
uniprot_entry
F8W6L1_HUMAN
resolver
uniprot_entry
Q5FBX8_HUMAN
resolver
uniprot_entry
TPO_HUMAN
resolver
uniprot_sec
A1L3Y0
resolver
uniprot_sec
B7ZLR8
resolver
uniprot_sec
B9EGA8
resolver
uniprot_sec
Q13020
resolver
uniprot_sec
Q15790
resolver
uniprot_sec
Q15791
resolver
uniprot_sec
Q15792
resolver
amino_acid_sequence
MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
uniprot
proteins
disease_involvement
DISEASE: Thrombocythemia 1 (THCYT1) [MIM:187950]: A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. {ECO:0000269|PubMed:9425899}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Amegakaryocytic thrombocytopenia, congenital, 2 (CAMT2) [MIM:620481]: A form of congenital amegakaryocytic thrombocytopenia, a hematologic disorder characterized by severe reduction of megakaryocytes and platelets at birth, and evolving into generalized bone marrow aplasia during childhood. CAMT2 is an autosomal recessive form. Most patients present with thrombocytopenia that progresses to pancytopenia. {ECO:0000269|PubMed:24085763, ECO:0000269|PubMed:28559357, ECO:0000269|PubMed:29191945, ECO:0000269|PubMed:36226497}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Thrombocytopenia 9 (THC9) [MIM:620478]: A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. THC9 is an autosomal dominant form characterized by low platelet counts in the absence of significant bleeding tendency. Some individuals may have mild mucocutaneous bleeding, whereas others may be asymptomatic. {ECO:0000269|PubMed:28466964, ECO:0000269|PubMed:32150607}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. {ECO:0000269|PubMed:24085763, ECO:0000269|PubMed:29191945}.
uniprot
proteins
mass_dalton
37823
uniprot
proteins
protein_family
EPO/TPO family
uniprot
proteins
pubmed
14769915
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24085763
uniprot
proteins
pubmed
28466964
uniprot
proteins
pubmed
28559357
uniprot
proteins
pubmed
29191945
uniprot
proteins
pubmed
32150607
uniprot
proteins
pubmed
36226497
uniprot
proteins
pubmed
37633268
uniprot
proteins
pubmed
7809166
uniprot
proteins
pubmed
7822271
uniprot
proteins
pubmed
7849319
uniprot
proteins
pubmed
7926023
uniprot
proteins
pubmed
8020099
uniprot
proteins
pubmed
8202154
uniprot
proteins
pubmed
8537317
uniprot
proteins
pubmed
8942648
uniprot
proteins
pubmed
9425899
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:32150607, ECO:0000269|PubMed:7822271}.
uniprot
proteins