Thg1l
entrez
66628
canonical
uniprot
Q9CY52
canonical
ensembl
ENSMUSG00000011254
resolver
ensp
ENSMUSP00000011398
resolver
ensp
ENSMUSP00000104877
resolver
ensp
ENSMUSP00000343313
resolver
enst
ENSMUST00000011398
resolver
enst
ENSMUST00000109254
resolver
genesymbol
Thg1l
resolver
uniprot
F7BGC2
resolver
uniprot
Q562D7
resolver
uniprot
Q9CQT0
resolver
uniprot_entry
F7BGC2_MOUSE
resolver
uniprot_entry
Q9CQT0_MOUSE
resolver
uniprot_entry
THG1_MOUSE
resolver
uniprot_sec
Q562D7
resolver
amino_acid_sequence
MWAFRTARIGSLLAATSVILRRCLRLGVAMAKSKFEYVRNFEVQDTCLPHCWVVVRLDGRNFHRFAEEHNFAKPNDSRALHLMTKCAQTVMEELEDIVIAYGQSDEYSFVFRKKSNWFKRRASKFMTLVASQFASSYVFYWRDYFEDQPLRYPPGFDGRVVLYPSNQTLKDYLSWRQADCHINNLYNTVFWALIQQSGLTPVQAQQRLKGTLTADKNEILFSEFHINYNNEPHMYRKGTVLVWQKVEEVRTQEVRLPAEMEGEKKAVARTRTRVVALNCDLIGDAFWKEHPEILAEEN
uniprot
proteins
ec_number
2.7.7.79
uniprot
proteins
function
FUNCTION: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress. {ECO:0000250|UniProtKB:Q9NWX6}.
uniprot
proteins
mass_dalton
34971
uniprot
proteins
protein_family
TRNA(His) guanylyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
298
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion {ECO:0000250|UniProtKB:Q9NWX6}.
uniprot
proteins