Fbxl15
entrez
68431
canonical
uniprot
Q91W61
canonical
ensembl
ENSMUSG00000025226
resolver
ensp
ENSMUSP00000026256
resolver
ensp
ENSMUSP00000137489
resolver
ensp
ENSMUSP00000206038
resolver
enst
ENSMUST00000026256
resolver
enst
ENSMUST00000177667
resolver
genesymbol
Fbxl15
resolver
genesymbol_syn
Fbxo37
resolver
uniprot
Q3T9R4
resolver
uniprot_entry
FXL15_MOUSE
resolver
uniprot_sec
Q3T9R4
resolver
amino_acid_sequence
MEPPMEQSGGEQEPGAVRLLDLPWEDVLLPHVLNWVPLRQLLRLQRVSRAFRALVQLHLARLRRFDAAQVGPQIPRAALARLLRDAEGLQELALAPCHEWLSDEDLVPVLARNPQLRSVALAGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDTAVQELARNCPQLEHLDLTGCLRVGSDGVRTLAEYCPALRSLRVRHCHHVAEPSLSRLRKRGVDIDVEPPLHQALVLLQDMAGFAPFVNLQV
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
33125
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
FBXL15 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21572392
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins