Aox1
entrez
54349
canonical
uniprot
Q9Z0U5
canonical
ensembl
ENSRNOG00000015354
resolver
ensp
ENSRNOP00000059651
resolver
ensp
ENSRNOP00000100414
resolver
enst
ENSRNOT00000171389
resolver
genesymbol
Aox1
resolver
genesymbol_syn
Ao
resolver
uniprot
A0ABK0L6H9
resolver
uniprot
Q9R240
resolver
uniprot_entry
A0ABK0L6H9_RAT
resolver
uniprot_entry
AOXA_RAT
resolver
uniprot_sec
Q9R240
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by menadione and isovanillin (PubMed:9224775). Inhibited by the flavonoids quercetin, myricetin and genistein (PubMed:23282065). Nitric oxide generation is inhibited by raloxifene and competitively inhibited by an increase in oxygen levels (PubMed:19801639). {ECO:0000269|PubMed:19801639, ECO:0000269|PubMed:23282065, ECO:0000269|PubMed:9224775}.
uniprot
proteins
amino_acid_sequence
MDPPQLLFYVNGQKVVENNVDPEMMLLPYLRKNLRLTGTKYGCGGGGCGACTVMISRYNPSTKSIRHHPVNACLTPICSLYGTAVTTVEGIGNTRTRLHPVQERIAKCHSTQCGFCTPGMVMSMYALLRNHPEPSLDQLTDALGGNLCRCTGYRPIIDACKTFCRASGCCESKENGVCCLDQGINGSAEFQEGDETSPELFSEKEFQPLDPTQELIFPPELMRIAEKQPPKTRVFYSNRMTWISPVTLEELVEAKFKYPGAPIVMGYTSVGPEVKFKGVFHPIIISPDRIEELSIINQTGDGLTLGAGLSLDQVKDILTDVVQKLPEETTQTYRALLKHLRTLAGSQIRNMASLGGHIVSRHLDSDLNPLLAVGNCTLNLLSKDGKRQIPLSEQFLRKCPDSDLKPQEVLVSVNIPCSRKWEFVSAFRQAQRQQNALAIVNSGMRVLFREGGGVIKELSILYGGVGPTTIGAKNSCQKLIGRPWNEEMLDTACRLVLDEVTLAGSAPGGKVEFKRTLIISFLFKFYLEVLQGLKREDPGHYPSLTNNYESALEDLHSKHHWRTLTHQNVDSMQLPQDPIGRPIMHLSGIKHATGEAIYCDDMPAVDRELFLTFVTSSRAHAKIVSIDLSEALSLPGVVDIITADHLQDATTFGTETLLATDKVHCVGQLVCAVIADSETRAKQAAKHVKVVYRDLEPLILTIEEAIQHKSFFESERKLECGNVDEAFKIADQILEGEIHIGGQEHFYMETQSMLVVPKGEDGEIDIYVSTQFPKHIQDIVAATLKLSVNKVMCHVRRVGGAFGGKVGKTSIMAAITAFAASKHGRAVRCTLERGEDMLITGGRHPYLGKYKVGFMRDGRIVALDVEHYCNGGSSLDESLWVIEMGLLKMDNAYKFPNLRCRGWACRTNLPSHTALRGFGFPQAGLVTEACVTEVAIRCGLSPEQVRTINMYKQIDNTHYKQEFSAKTLFECWRECMAKCSYSERKTAVGKFNAENSWKKRGMAVIPLKFPVGVGSVAMGQAAALVHIYLDGSALVSHGGIEMGQGVHTKMIQVVSRELKMPMSSVHLRGTSTETVPNTNASGGSVVADLNGLAVKDACQTLLKRLEPIISKNPQGTWKDWAQTAFDQSVSLSAVGYFRGYESNINWEKGEGHPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGHSINPALDIGQVEGAFIQGMGLYTIEELSYSPQGILYSRGPNQYKIPAICDIPTEMHISFLPPSEHSNTLYSSKGLGESGVFLGCSVFFAIHDAVRAARQERGISGPWKLTSPLTPEKIRMACEDKFTKMIPRDEPGSYVPWNIPV
uniprot
proteins
ec_number
1.17.3.-
uniprot
proteins
ec_number
1.2.3.1
uniprot
proteins
ec_number
1.2.3.8
uniprot
proteins
ec_number
1.2.3.9
uniprot
proteins
function
FUNCTION: Primarily catalyzes oxidation reactions of a broad range of drug and xenobiotic substrates and participates in their metabolism through oxidative biotransformation (PubMed:17353002, PubMed:23282065, PubMed:4256441, PubMed:9224775, PubMed:9920943). Oxidizes at least three structural types of substrates: aldehydes such as benzaldehyde, retinal, pyridoxal, and vanillin; aromatic azaheterocyclic compounds such as phthalazine, quinazoline and phenanthridine; and quaternary azaheterocyclic compounds such as 1-methylnicotinamide and nicotine imine (PubMed:17353002, PubMed:23282065, PubMed:4256441, PubMed:9224775, PubMed:9920943). Converts aldehydes to carboxylic acids, aromatic and quaternary azaheterocyclic compounds to lactams, typically by using molecular oxygen as the terminal electron acceptor and producing hydrogen peroxide as a by-product (PubMed:17353002, PubMed:23282065, PubMed:4256441, PubMed:9224775, PubMed:9920943). Under some conditions, especially with electron-deficient substrates or limited oxygen, can also catalyze reduction reactions using N-methylnicotinamide, 2-hydroxypyrimidine or benzaldehyde as electron donor substrate (PubMed:15720138, PubMed:19801639). These reductive activities include N-O bond reductions in nitro groups (e.g., imidacloprid, IMI), hydroxamic acids, and oxazoles (e.g., zonisamide), as well as N-S bond reductions of sulfoxides (e.g., sulindac) (By similarity). {ECO:0000250|UniProtKB:Q5FB27, ECO:0000269|PubMed:15720138, ECO:0000269|PubMed:17353002, ECO:0000269|PubMed:19801639, ECO:0000269|PubMed:23282065, ECO:0000269|PubMed:4256441, ECO:0000269|PubMed:9224775, ECO:0000269|PubMed:9920943}.
uniprot
proteins
mass_dalton
146921
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.
uniprot
proteins
protein_family
Xanthine dehydrogenase family
uniprot
proteins
pubmed
15720138
uniprot
proteins
pubmed
17353002
uniprot
proteins
pubmed
19801639
uniprot
proteins
pubmed
23263164
uniprot
proteins
pubmed
23282065
uniprot
proteins
pubmed
4256441
uniprot
proteins
pubmed
9224775
uniprot
proteins
pubmed
9920943
uniprot
proteins
sequence_length
1333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17353002}.
uniprot
proteins