Impa1
entrez
83523
canonical
uniprot
P97697
canonical
ensembl
ENSRNOG00000010482
resolver
ensp
ENSRNOP00000014274
resolver
ensp
ENSRNOP00000110780
resolver
enst
ENSRNOT00000014274
resolver
enst
ENSRNOT00000132949
resolver
genesymbol
Impa1
resolver
genesymbol_syn
Imp
resolver
uniprot
A0ABK0LIU5
resolver
uniprot
F1M978
resolver
uniprot_entry
A0ABK0LIU5_RAT
resolver
uniprot_entry
F1M978_RAT
resolver
uniprot_entry
IMPA1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activity with myo-inositol monophosphate and D-galactose 1-phosphate is inhibited by Li(+), Ca(2+) and Mn(2+), but also by Mg(2+) at concentrations above 3 mM. {ECO:0000269|PubMed:9462881}.
uniprot
proteins
amino_acid_sequence
MADPWQECMDYAVILARQAGEMIREALKNKMDVMIKSSPADLVTVTDQKVEKMLMSSIKEKYPYHSFIGEESVASGEKTVFTEQPTWIIDPIDGTTNFVHRFPFVAVSIGFVVNKEMEFGVVYSCVEDKMYTGRKGKGAFCNGQKLRVSQQEDITKSLLVTELGSSRKPETLRIVLSNMERLCSIPIHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDMAGAGIIVIEAGGVLLDVTGGPFDLMSRRIIAASNIALAERIAKELEIIPLQRDDES
uniprot
proteins
ec_number
3.1.3.25
uniprot
proteins
ec_number
3.1.3.94
uniprot
proteins
function
FUNCTION: Phosphatase involved in the dephosphorylation of myo-inositol monophosphate to generate myo-inositol (PubMed:9462881). Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate (By similarity). Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP (PubMed:9462881). Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides, and involved in maintaining normal brain function. Has been implicated as the pharmacological target for lithium Li(+) action in brain (By similarity). Is equally active with myo-inositol monophosphate and D-galactose 1-phosphate (PubMed:9462881). {ECO:0000250|UniProtKB:P29218, ECO:0000269|PubMed:9462881}.
uniprot
proteins
mass_dalton
30511
uniprot
proteins
pathway_participation
PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
uniprot
proteins
protein_family
Inositol monophosphatase superfamily
uniprot
proteins
pubmed
1377913
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9210592
uniprot
proteins
pubmed
9462881
uniprot
proteins
sequence_length
277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P29218}.
uniprot
proteins