Ttll7
entrez
70892
canonical
uniprot
A4Q9F0
canonical
ensembl
ENSMUSG00000036745
resolver
ensp
ENSMUSP00000043753
resolver
ensp
ENSMUSP00000101740
resolver
ensp
ENSMUSP00000166439
resolver
enst
ENSMUST00000037942
resolver
enst
ENSMUST00000106134
resolver
genesymbol
Ttll7
resolver
uniprot
A0A0G2LB90
resolver
uniprot
A4Q9E9
resolver
uniprot
E9Q6C6
resolver
uniprot
Q8C417
resolver
uniprot
Q9D5V3
resolver
uniprot_entry
A0A0G2LB90_MOUSE
resolver
uniprot_entry
E9Q6C6_MOUSE
resolver
uniprot_entry
TTLL7_MOUSE
resolver
uniprot_sec
A4Q9E9
resolver
uniprot_sec
Q8C417
resolver
uniprot_sec
Q9D5V3
resolver
amino_acid_sequence
MPSLPQDGVIQGSSPVDLGTELPYQCTMKRKVRKKKKKGIITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDAAVQQEKITDLQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPMDYTFVPRTWIFPSEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKVPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNERFERNETEDKGSKRSIKWFTEFLQANQHDVTKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRKNLAKQKAEAQRRLYGQNPVRRLSPGSSDWEQQRHQLERRKEELKERLLQVRKQVSQEEHENRHMGNYRRIYPPEDKALLEKYEGLLAVAFQTFLSGRAASFQREMNNPLKKMREEDLLDLLEQCEIDDEKLMGKTGRVRGPKPLCCMPECAEVTKKQKYYGSSDSSYDSSSSSSNSELDENEKELCQKRLDQVPYSLKHTSHCKIIQQPSGSHNLIYSESPVYLTTLVFLSEFPDSMRRSVSCPRSISAHLPSRGDVRPFSSQQVIPLARPTSASRSHSLNRASSYARHLPHGSDTGSTNTLNESLRQLKTKEQEDDLTSQTLFVLKDMRIRFPGKSDAESELLIEDIMDNWKHYKTKVASYWLIKLDSVKQRKVLDIVKSSIRTVLPRIWRVPDAEELSLYRIFNRVFNRLLWSHGQGLWSCFCDSGSSWESIFSKSPEVVTPLQLQCCQRLVELCKQCLLVVYKYTTETRGPISGIGPDWGNSRYLLPGSTQFLMRSPLYNMKYNSPGMTRSNVLFTSRYGRL
uniprot
proteins
ec_number
6.3.2.-
uniprot
proteins
function
FUNCTION: Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:16901895, PubMed:17499049, PubMed:19152315). Mediates both ATP-dependent initiation and elongation steps of the polyglutamylation reaction (PubMed:16901895, PubMed:17499049, PubMed:19152315). Preferentially modifies the beta-tubulin tail over an alpha-tail (PubMed:16901895, PubMed:17499049, PubMed:19152315). Competes with monoglycylase TTLL3 for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions (By similarity). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (PubMed:16901895). {ECO:0000250|UniProtKB:F7E540, ECO:0000269|PubMed:16901895, ECO:0000269|PubMed:17499049, ECO:0000269|PubMed:19152315}.
uniprot
proteins
mass_dalton
105501
uniprot
proteins
mutagenesis
MUTAGEN 349; /note="E->V: Loss of activity."; /evidence="ECO:0000269|PubMed:16901895
uniprot
proteins
protein_family
Tubulin--tyrosine ligase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16901895
uniprot
proteins
pubmed
17499049
uniprot
proteins
pubmed
19152315
uniprot
proteins
sequence_length
912
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:16901895, ECO:0000269|PubMed:17499049}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:16901895, ECO:0000269|PubMed:17499049}. Cell projection, dendrite {ECO:0000269|PubMed:16901895, ECO:0000269|PubMed:17499049}. Perikaryon {ECO:0000269|PubMed:16901895, ECO:0000269|PubMed:17499049}. Note=In cells with primary cilia, found in both cilia and basal bodies. In neuronal cells, found in dendrites and perikaryon. {ECO:0000269|PubMed:16901895, ECO:0000269|PubMed:17499049}.
uniprot
proteins