PELO
entrez
53918
canonical
uniprot
Q9BRX2
canonical
ensembl
ENSG00000152684
resolver
ensp
ENSP00000274311
resolver
ensp
ENSP00000571318
resolver
ensp
ENSP00000571319
resolver
enst
ENST00000274311
resolver
enst
ENST00000901259
resolver
enst
ENST00000901260
resolver
genesymbol
PELO
resolver
hgnc
HGNC:8829
resolver
uniprot
Q9GZS6
resolver
uniprot
Q9Y306
resolver
uniprot_entry
PELO_HUMAN
resolver
uniprot_sec
Q9GZS6
resolver
uniprot_sec
Q9Y306
resolver
amino_acid_sequence
MKLVRKNIEKDNAGQVTLVPEEPEDMWHTYNLVQVGDSLRASTIRKVQTESSTGSVGSNRVRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSVVLERIEQACDPAWSADVAAVVMQEGLAHICLVTPSMTLTRAKVEVNIPRKRKGNCSQHDRALERFYEQVVQAIQRHIHFDVVKCILVASPGFVREQFCDYLFQQAVKTDNKLLLENRSKFLQVHASSGHKYSLKEALCDPTVASRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKQVEKANEAMAIDTLLISDELFRHQDVATRSRYVRLVDSVKENAGTVRIFSSLHVSGEQLSQLTGVAAILRFPVPELSDQEGDSSSEED
uniprot
proteins
function
FUNCTION: Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27543824, PubMed:27863242). In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27543824, PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27543824, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:32006463}.
uniprot
proteins
mass_dalton
43359
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="K->A: Abolished ability to rescue stalled ribosomes."; /evidence="ECO:0000269|PubMed:27543824"; MUTAGEN 45; /note="R->A: Abolished ability to rescue stalled ribosomes."; /evidence="ECO:0000269|PubMed:27543824
uniprot
proteins
protein_family
Eukaryotic release factor 1 family
uniprot
proteins
protein_family
Pelota subfamily
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11060452
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21448132
uniprot
proteins
pubmed
23667253
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27543824
uniprot
proteins
pubmed
27863242
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29861391
uniprot
proteins
pubmed
32006463
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:21448132}.
uniprot
proteins