D3ZXK7
uniprot
D3ZXK7
canonical
amino_acid_sequence
MTSKGAAMSFSRKSYRLTSDAEKSRVTGIVQEKLLSDYLYRIFSSPDHGTPAATSRKPLNFHNLPEHVDQLLQVDDEESQGQVEGRLGPSTVVLDHTGGFEGLLLVDDDLLGVIGHSNFGTIRSSTCVYKGKWVYEVLISSQGLMQIGWCTINCRFNQEEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSLGTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGFRPLQDPPFADLVRAQRLLGCFQTVLSVELDPVEGRLVEKESSEWQLHGQPTVLLTLAHIFHHFAPLLRKVYLVEAVLMSFLLGIVEKGTPEQAQSVVHQILDLLWLFMEDYEVQDCLKQLMMSLLRLYRFSPIVPDLGLQIHYLRLTMAVLRHEKSRKFLLSNVLFDMLRSVVFFYIKSPLRVEEAGLKELIPTTWWPHRSSREGRDGQEAKEETTEERQRRRAYERGCQRLKKRIEVVEELQVQILKLLLDNKDDNGGEASRYIFLTKFRKFLQENASGRGNTPVLCPPEYMVCFLHRLVSALRFYWDEYKASNPRASFSDEAYIPPQIFYNGKVDYFDLQRLGGLLSHLRKTLKDDLASKANIVIDPLELQAATMDDLDEDEEPAPTAAQSWRARQRPVQALAIGGALPLPRPGWLSSPTLGRANRFLSTAAVSLMTPRRLLSTMEKVKVRSLNVEQRTREDIEGSHWNEGLLLGRPPEEPERPLTENSLLEVLDGTVMMYSLSVHQQLGKMVGVSDDVNEYAMALRDTEDKLRRCPKRRKDILAELTKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLQTIEHGDRTGSLFAFMPEFYLSVAINSYSALKNYFGPVHSMEELPGYEETLTRLAAILAKHFADPRIVGTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQTNWILVRLWRGCGFGYRYTRLPHLLKTKPEDANLPSLQKPCPSTLLQQHMADLLRQGSDVAPSFLNSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLLRVLEMTITLVPEIFLDWSRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGLESVDHYPILVAVTGILVRLLAHGPSSETEQATSVLLADPCFQLRSIRYLLGQPEPLAPGSALPAPDRKRFSLQSYADYISAEELAQVERMLAHLTAASAQAAAASLPTNEEDLCPICYAHPISAVFQPCGHKSCKACINQHLMNNKDCFFCKATIVSVEDWDKAASTSATSSAA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B: acts by catalyzing ubiquitination of the NFKB1 p105 precursor, leading to limited proteasomal degradation of NFKB1 p105 and generation of the active NFKB1 p50 subunit. Functions also as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS. {ECO:0000250|UniProtKB:Q5XPI4}.
uniprot
proteins
mass_dalton
149077
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q5XPI4}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation (PubMed:19015242). Deubiquitinated by USP19, thereby stimulating CDKN1B ubiquitin-dependent degradation (PubMed:19015242). {ECO:0000269|PubMed:19015242}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
19015242
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5XPI4}.
uniprot
proteins