SHC1
entrez
6464
canonical
uniprot
P29353
canonical
ensembl
ENSG00000160691
resolver
ensp
ENSP00000357430
resolver
ensp
ENSP00000357434
resolver
ensp
ENSP00000357435
resolver
ensp
ENSP00000357438
resolver
ensp
ENSP00000401303
resolver
ensp
ENSP00000545619
resolver
ensp
ENSP00000545620
resolver
ensp
ENSP00000545621
resolver
ensp
ENSP00000545624
resolver
ensp
ENSP00000625167
resolver
ensp
ENSP00000693019
resolver
ensp
ENSP00000735884
resolver
genesymbol
SHC1
resolver
genesymbol_syn
SHC
resolver
genesymbol_syn
SHCA
resolver
hgnc
HGNC:10840
resolver
uniprot
B5BU19
resolver
uniprot
D3DV78
resolver
uniprot
O15290
resolver
uniprot
Q5T180
resolver
uniprot
Q5T183
resolver
uniprot
Q5T184
resolver
uniprot
Q5T185
resolver
uniprot
Q5T186
resolver
uniprot
Q8N4K5
resolver
uniprot
Q96CL1
resolver
uniprot_entry
SHC1_HUMAN
resolver
uniprot_sec
B5BU19
resolver
uniprot_sec
D3DV78
resolver
uniprot_sec
O15290
resolver
uniprot_sec
Q5T180
resolver
uniprot_sec
Q5T183
resolver
uniprot_sec
Q5T184
resolver
uniprot_sec
Q5T185
resolver
uniprot_sec
Q5T186
resolver
uniprot_sec
Q8N4K5
resolver
uniprot_sec
Q96CL1
resolver
amino_acid_sequence
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL
uniprot
proteins
function
FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. Involved in the oncostatin-M-mediated signaling pathway through type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) where it contributes to activation of the Ras/Raf/MAPK pathway through JAK1-dependent recruitment to OSMR subunit of OSMR complex and SHC1 association with GRB2 (PubMed:11016927). {ECO:0000250, ECO:0000269|PubMed:11016927, ECO:0000269|PubMed:14665640}.
uniprot
proteins
mass_dalton
62822
uniprot
proteins
mutagenesis
MUTAGEN 349; /note="Y->F: Alters interaction with GRB2; isoform p52Shc (in vitro)."; /evidence="ECO:0000269|PubMed:9488479"; MUTAGEN 427; /note="Y->F: No effect on interaction with GRB2; isoform p52Shc (in vitro)."; /evidence="ECO:0000269|PubMed:9488479
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to FLT4 and KIT signaling. Isoform p46Shc and isoform p52Shc are phosphorylated on tyrosine residues of the Pro-rich domain. Isoform p66Shc is phosphorylated on Ser-36 by PRKCB upon treatment with insulin, hydrogen peroxide or irradiation with ultraviolet light (By similarity). Tyrosine phosphorylated in response to FLT3 signaling (By similarity). Tyrosine phosphorylated by activated PTK2B/PYK2 (By similarity). Tyrosine phosphorylated by ligand-activated ALK. Tyrosine phosphorylated by ligand-activated PDGFRB. Tyrosine phosphorylated by TEK/TIE2. May be tyrosine phosphorylated by activated PTK2/FAK1; tyrosine phosphorylation was seen in an astrocytoma biopsy, where PTK2/FAK1 kinase activity is high, but not in normal brain tissue. Isoform p52Shc dephosphorylation by PTPN2 may regulate interaction with GRB2. Oncostatin-M-mediated signaling pathway induces phosphorylation at tyrosine residues by JAK1 leading to its activation and allows, concomitantly, SHC1 recruitment to OSMR subunit of OSMR complex and SHC1 association with GRB2 (PubMed:11016927). {ECO:0000250, ECO:0000269|PubMed:11016927, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:14665640, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:15837797, ECO:0000269|PubMed:17274988, ECO:0000269|PubMed:8195171, ECO:0000269|PubMed:8939605, ECO:0000269|PubMed:9121430, ECO:0000269|PubMed:9148935, ECO:0000269|PubMed:9488479, ECO:0000269|PubMed:9566877}.
uniprot
proteins
pubmed
10194451
uniprot
proteins
pubmed
10867024
uniprot
proteins
pubmed
11016927
uniprot
proteins
pubmed
11349134
uniprot
proteins
pubmed
11948181
uniprot
proteins
pubmed
11980671
uniprot
proteins
pubmed
12925710
uniprot
proteins
pubmed
14573619
uniprot
proteins
pubmed
14665640
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15102829
uniprot
proteins
pubmed
15272003
uniprot
proteins
pubmed
15316024
uniprot
proteins
pubmed
15488758
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15526160
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15837797
uniprot
proteins
pubmed
1623525
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17274988
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
19172738
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20010870
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23846654
uniprot
proteins
pubmed
23946459
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
35687021
uniprot
proteins
pubmed
7473762
uniprot
proteins
pubmed
7537849
uniprot
proteins
pubmed
7541045
uniprot
proteins
pubmed
7544002
uniprot
proteins
pubmed
7559478
uniprot
proteins
pubmed
8155326
uniprot
proteins
pubmed
8195171
uniprot
proteins
pubmed
8524391
uniprot
proteins
pubmed
8874179
uniprot
proteins
pubmed
8939605
uniprot
proteins
pubmed
8940081
uniprot
proteins
pubmed
9038210
uniprot
proteins
pubmed
9049300
uniprot
proteins
pubmed
9121430
uniprot
proteins
pubmed
9148935
uniprot
proteins
pubmed
9192859
uniprot
proteins
pubmed
9233773
uniprot
proteins
pubmed
9488479
uniprot
proteins
pubmed
9566877
uniprot
proteins
pubmed
9660833
uniprot
proteins
sequence_length
583
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion {ECO:0000269|PubMed:35687021}.; SUBCELLULAR LOCATION: [Isoform p46Shc]: Mitochondrion matrix {ECO:0000269|PubMed:14573619}. Note=Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.; SUBCELLULAR LOCATION: [Isoform p66Shc]: Mitochondrion {ECO:0000250}. Note=In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation. {ECO:0000250}.
uniprot
proteins