CDC26
entrez
246184
canonical
uniprot
Q8NHZ8
canonical
ensembl
ENSG00000176386
resolver
ensp
ENSP00000363322
resolver
ensp
ENSP00000538523
resolver
ensp
ENSP00000538524
resolver
ensp
ENSP00000538525
resolver
ensp
ENSP00000538526
resolver
ensp
ENSP00000538527
resolver
ensp
ENSP00000538528
resolver
ensp
ENSP00000538529
resolver
ensp
ENSP00000538530
resolver
ensp
ENSP00000538531
resolver
ensp
ENSP00000538532
resolver
ensp
ENSP00000538533
resolver
ensp
ENSP00000538534
resolver
ensp
ENSP00000538535
resolver
ensp
ENSP00000538536
resolver
ensp
ENSP00000538537
resolver
ensp
ENSP00000538538
resolver
ensp
ENSP00000538539
resolver
ensp
ENSP00000584976
resolver
ensp
ENSP00000584977
resolver
ensp
ENSP00000584978
resolver
ensp
ENSP00000584979
resolver
ensp
ENSP00000584980
resolver
ensp
ENSP00000584981
resolver
ensp
ENSP00000584982
resolver
ensp
ENSP00000584983
resolver
ensp
ENSP00000584984
resolver
ensp
ENSP00000584985
resolver
ensp
ENSP00000584986
resolver
ensp
ENSP00000584987
resolver
ensp
ENSP00000584988
resolver
ensp
ENSP00000584989
resolver
ensp
ENSP00000584990
resolver
ensp
ENSP00000624079
resolver
ensp
ENSP00000624080
resolver
ensp
ENSP00000624081
resolver
enst
ENST00000374206
resolver
enst
ENST00000868464
resolver
enst
ENST00000868465
resolver
enst
ENST00000868466
resolver
enst
ENST00000868467
resolver
enst
ENST00000868468
resolver
enst
ENST00000868469
resolver
enst
ENST00000868470
resolver
enst
ENST00000868471
resolver
enst
ENST00000868472
resolver
enst
ENST00000868473
resolver
enst
ENST00000868474
resolver
enst
ENST00000868475
resolver
enst
ENST00000868476
resolver
enst
ENST00000868477
resolver
enst
ENST00000868478
resolver
enst
ENST00000868479
resolver
enst
ENST00000868480
resolver
enst
ENST00000914917
resolver
enst
ENST00000914918
resolver
enst
ENST00000914919
resolver
enst
ENST00000914920
resolver
enst
ENST00000914921
resolver
enst
ENST00000914922
resolver
enst
ENST00000914923
resolver
enst
ENST00000914924
resolver
enst
ENST00000914925
resolver
enst
ENST00000914926
resolver
enst
ENST00000914927
resolver
enst
ENST00000914928
resolver
enst
ENST00000914929
resolver
enst
ENST00000914930
resolver
enst
ENST00000914931
resolver
enst
ENST00000954020
resolver
enst
ENST00000954021
resolver
enst
ENST00000954022
resolver
genesymbol
CDC26
resolver
genesymbol_syn
ANAPC12
resolver
genesymbol_syn
C9orf17
resolver
hgnc
HGNC:17839
resolver
uniprot_entry
CDC26_HUMAN
resolver
amino_acid_sequence
MLRRKPTRLELKLDDIEEFENIRKDLETRKKQKEDVEVVGGSDGEGAIGLSSDPKSREQMINDRIGYKPQPKPNNRSSQFGSLEF
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:18485873, PubMed:27120157, PubMed:27509861). Together with the RING-H2 protein ANAPC11, forms the catalytic component of the E3 ubiquitin ligase complex (PubMed:18485873, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (PubMed:27509861). May recruit the E2 ubiquitin-conjugating enzymes to the complex (PubMed:18485873). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:27120157, ECO:0000269|PubMed:27509861, ECO:0000269|PubMed:29033132}.
uniprot
proteins
mass_dalton
9777
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
uniprot
proteins
protein_family
CDC26 family
uniprot
proteins
pubmed
10922056
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16364912
uniprot
proteins
pubmed
18485873
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19668213
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25043029
uniprot
proteins
pubmed
26083744
uniprot
proteins
pubmed
27120157
uniprot
proteins
pubmed
27509861
uniprot
proteins
pubmed
29033132
uniprot
proteins
pubmed
34595750
uniprot
proteins
sequence_length
85
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins