Popdc1
entrez
365603
canonical
uniprot
Q3BCU4
canonical
ensembl
ENSRNOG00000043199
resolver
ensembl
ENSRNOG00055000845
resolver
ensembl
ENSRNOG00060006960
resolver
ensembl
ENSRNOG00065008689
resolver
ensp
ENSRNOP00000091870
resolver
ensp
ENSRNOP00000105633
resolver
ensp
ENSRNOP00055001157
resolver
ensp
ENSRNOP00060008534
resolver
ensp
ENSRNOP00065010268
resolver
enst
ENSRNOT00000162385
resolver
enst
ENSRNOT00055001429
resolver
enst
ENSRNOT00060011411
resolver
enst
ENSRNOT00065013819
resolver
genesymbol
Popdc1
resolver
genesymbol_syn
Bves
resolver
genesymbol_syn
Pop1
resolver
uniprot_entry
POPD1_RAT
resolver
amino_acid_sequence
MNFTEPSPLAQSTVVGFLPELESLTPVPSNETSCENWREVHHLVFHAANVCFAVGLLIPTTLHLHMILLRVMLSIGCTLYVVWATLYRCALDMMIWNSVFLGINILHLSYLLYKKRPVKIEKDLGGVYHRLFEPLRVPPDLFRRLTGQFCVIQTLKRGQVYATEDKTSVDDRLSILLKGRMKVSYRGHFLHNIYPCAFIDSPEFRSTQMHKGEKFQVTIVADDNCRFLCWSRERLTYFLESEPFLYEIFRYLIGKDITNKLYSLNDPTLNDKKVKKLEPQMSLSTQISMLEMRNSITSSSDIEDGLHHFLRGSSSTASLPMSSPQQRASPKMKPIEEGLEDDDEVFVPVSPAHQLP
uniprot
proteins
function
FUNCTION: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Important for skeletal muscle and heart development. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury (By similarity). {ECO:0000250|UniProtKB:Q5PQZ7, ECO:0000250|UniProtKB:Q8NE79, ECO:0000250|UniProtKB:Q9ES83}.
uniprot
proteins
mass_dalton
40860
uniprot
proteins
protein_family
Popeye family
uniprot
proteins
pubmed
17662479
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24066022
uniprot
proteins
sequence_length
356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lateral cell membrane {ECO:0000250|UniProtKB:Q8NE79}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q8NE79}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane, sarcolemma {ECO:0000269|PubMed:24066022}. Membrane, caveola {ECO:0000269|PubMed:24066022}. Note=Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle (By similarity). Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Detected at cell-cell contact but never observed at the free surface of epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q9ES83}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins