Foxo4
entrez
54601
canonical
uniprot
Q9WVH3
canonical
ensembl
ENSMUSG00000042903
resolver
ensp
ENSMUSP00000059420
resolver
enst
ENSMUST00000062000
resolver
genesymbol
Foxo4
resolver
genesymbol_syn
Afx
resolver
genesymbol_syn
Afx1
resolver
genesymbol_syn
Fkhr3
resolver
genesymbol_syn
Mllt7
resolver
uniprot
B1AUT3
resolver
uniprot
Q4KL34
resolver
uniprot_entry
B1AUT3_MOUSE
resolver
uniprot_entry
FOXO4_MOUSE
resolver
uniprot_entry
Q4KL34_MOUSE
resolver
amino_acid_sequence
MDPENKKSATGAAAILDLDPDFEPQSRPRSCTWPLPRPDLATEPHEPSEVEPSLGQKVPTEGHSEPILLPSRLPEPAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPDGGKGGKAPRRRAASMDSSSKLLRGRSKGPKKKPSVLPAPPEGATPRSPLGHFAKWSSSPCPRNREEADVWTTFRPRSSSNASTVSTRLSPMRPESEVLAEEEMPASASSYAGGVPPTLSEDLELLDGLNLASPHSLLSRSGLSGFSLQHPGLAGPLHSYGASLFGPIDGSLSAGEGCFSSSQSLEALLTSDTPPPPADVLMTQVDPILSQAPTLLLLGGMPSSSKLGTGVSLCPTPLEGPGPSNLVPNLSVMAPPPVMAGAPIPKVLGTPVLASPTEDSSHDRMPQDLDLDMYMENLECDMDNIISDLMDGEGLDFNFEPDP
uniprot
proteins
function
FUNCTION: Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity (By similarity). Represses smooth muscle cell differentiation by inhibiting the transcriptional coactivator activity of myocardin. {ECO:0000250|UniProtKB:P98177, ECO:0000269|PubMed:16054032}.
uniprot
proteins
mass_dalton
53649
uniprot
proteins
post_translational_modification
PTM: Acetylation by CREBBP/CBP is induced by oxidative stress and inhibits transcriptional activity. Deacetylation by SIRT1 is NAD-dependent and stimulates transcriptional activity (By similarity). {ECO:0000250|UniProtKB:P98177}.; PTM: Phosphorylation by PKB/AKT1 inhibits transcriptional activity and is responsible for cytoplasmic localization. May be phosphorylated at multiple sites by NLK (By similarity). {ECO:0000250|UniProtKB:P98177}.; PTM: Monoubiquitinated; monoubiquitination is induced by oxidative stress and reduced by deacetylase inhibitors; results in its relocalization to the nucleus and its increased transcriptional activity. Deubiquitinated by USP7; deubiquitination is induced by oxidative stress; enhances its interaction with USP7 and consequently, deubiquitination; increases its translocation to the cytoplasm and inhibits its transcriptional activity. Hydrogen-peroxide-induced ubiquitination and USP7-mediated deubiquitination have no major effect on its protein stability (By similarity). {ECO:0000250|UniProtKB:P98177}.
uniprot
proteins
pubmed
11353388
uniprot
proteins
pubmed
16054032
uniprot
proteins
pubmed
22510882
uniprot
proteins
pubmed
22956541
uniprot
proteins
sequence_length
505
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm (By similarity). {ECO:0000250|UniProtKB:P98177}.
uniprot
proteins