Gpx1
entrez
14775
canonical
uniprot
P11352
canonical
ensembl
ENSMUSG00000063856
resolver
ensp
ENSMUSP00000081010
resolver
ensp
ENSMUSP00000141279
resolver
enst
ENSMUST00000193987
resolver
genesymbol
Gpx1
resolver
uniprot
A0A0A6YVV2
resolver
uniprot
P12079
resolver
uniprot
Q544W3
resolver
uniprot
Q5RJH8
resolver
uniprot
Q9CR54
resolver
uniprot_entry
A0A0A6YVV2_MOUSE
resolver
uniprot_entry
GPX1_MOUSE
resolver
uniprot_sec
P12079
resolver
uniprot_sec
Q544W3
resolver
uniprot_sec
Q5RJH8
resolver
uniprot_sec
Q9CR54
resolver
amino_acid_sequence
MCAARLSAAAQSTVYAFSARPLTGGEPVSLGSLRGKVLLIENVASLUGTTIRDYTEMNDLQKRLGPRGLVVLGFPCNQFGHQENGKNEEILNSLKYVRPGGGFEPNFTLFEKCEVNGEKAHPLFTFLRNALPTPSDDPTALMTDPKYIIWSPVCRNDIAWNFEKFLVGPDGVPVRRYSRRFRTIDIEPDIETLLSQQSGNS
uniprot
proteins
ec_number
1.11.1.12
uniprot
proteins
ec_number
1.11.1.9
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:10754271, PubMed:21420488, PubMed:36608588, PubMed:9126277, PubMed:9195979, PubMed:9712879). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:10754271, PubMed:21420488, PubMed:36608588, PubMed:9126277, PubMed:9195979, PubMed:9712879). In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway (PubMed:9195979). {ECO:0000269|PubMed:10754271, ECO:0000269|PubMed:21420488, ECO:0000269|PubMed:36608588, ECO:0000269|PubMed:9126277, ECO:0000269|PubMed:9195979, ECO:0000269|PubMed:9712879}.
uniprot
proteins
mass_dalton
22329
uniprot
proteins
post_translational_modification
PTM: During periods of oxidative stress, Sec-47 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine. {ECO:0000269|PubMed:21420488}.
uniprot
proteins
protein_family
Glutathione peroxidase family
uniprot
proteins
pubmed
10754271
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17503775
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21420488
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
2771650
uniprot
proteins
pubmed
3015592
uniprot
proteins
pubmed
32358195
uniprot
proteins
pubmed
36608588
uniprot
proteins
pubmed
9126277
uniprot
proteins
pubmed
9195979
uniprot
proteins
pubmed
9712879
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10754271, ECO:0000269|PubMed:9126277}. Mitochondrion {ECO:0000269|PubMed:10754271, ECO:0000269|PubMed:9126277}.
uniprot
proteins