Dnajb12
entrez
56709
canonical
uniprot
Q9QYI4
canonical
ensembl
ENSMUSG00000020109
resolver
ensp
ENSMUSP00000020309
resolver
ensp
ENSMUSP00000116577
resolver
ensp
ENSMUSP00000118088
resolver
ensp
ENSMUSP00000122056
resolver
enst
ENSMUST00000020309
resolver
enst
ENSMUST00000142819
resolver
enst
ENSMUST00000146590
resolver
enst
ENSMUST00000147914
resolver
genesymbol
Dnajb12
resolver
uniprot
F7CVR7
resolver
uniprot
Q8C4C9
resolver
uniprot
Q8K037
resolver
uniprot_entry
DJB12_MOUSE
resolver
uniprot_entry
F7CVR7_MOUSE
resolver
uniprot_entry
Q8C4C9_MOUSE
resolver
uniprot_sec
Q8K037
resolver
amino_acid_sequence
MESNKDEAERCISIALKAIQSNQPERALRFLEKAQRLYPTPRVSALIESLNQKPQSTGDHPQPTDTTHTTTKKAGGTETPSANGEAGGGESAKGYTSEQVAAVKRVKQCKDYYEILGVSRSASDEDLKKAYRKLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYDQFGDDKSQAARHGHSHGDFHRGFEADISPEDLFNMFFGGGFPSSNVHVYSNGRMRYTYQQRQDRRDNQGDGGLGVFVQLMPILILILVSALSQLMVSSPPYSLSPRPSVGHIHKRVTDHLNVAYYVADTFSEEYTGSSLKTVERNVEDDYIANLRNNCWKEKQQKEGLLYRARYFGDTDMYHRAQKMGTPSCNRLSEVQASLHG
uniprot
proteins
function
FUNCTION: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear. {ECO:0000250|UniProtKB:Q9NXW2}.
uniprot
proteins
mass_dalton
41988
uniprot
proteins
post_translational_modification
PTM: Methylated at His-186 by METTL9. {ECO:0000250|UniProtKB:Q9NXW2}.
uniprot
proteins
protein_family
DNAJB12/DNAJB14 subfamily
uniprot
proteins
protein_family
DnaJ family
uniprot
proteins
pubmed
11147971
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NXW2}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:Q9NXW2}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9NXW2}. Note=Localizes to the endoplasmic reticulum membrane. When overexpressed, forms membranous structures in the nucleus. {ECO:0000250|UniProtKB:Q9NXW2}.
uniprot
proteins
transmembrane_region
TRANSMEM 243..263; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins