Hsd3b1
entrez
15492
canonical
uniprot
P24815
canonical
ensembl
ENSMUSG00000027871
resolver
ensp
ENSMUSP00000029465
resolver
ensp
ENSMUSP00000102630
resolver
enst
ENSMUST00000029465
resolver
enst
ENSMUST00000107016
resolver
genesymbol
Hsd3b1
resolver
genesymbol_syn
Hsd3b
resolver
uniprot
A2AEP8
resolver
uniprot
Q3UI20
resolver
uniprot
Q3UJ12
resolver
uniprot
Q7TQ00
resolver
uniprot_entry
3BHS1_MOUSE
resolver
uniprot_entry
Q3UI20_MOUSE
resolver
uniprot_entry
Q3UJ12_MOUSE
resolver
uniprot_sec
A2AEP8
resolver
uniprot_sec
Q7TQ00
resolver
amino_acid_sequence
MAGWSCLVTGAGGFVGQRIIKMLVQEKELQEVRALDKVFRPETKEEFSKLQTKTKVTVLEGDILDAQCLRRACQGISVVIHTAAVIDVTGVIPRQTILDVNLKGTQNLLEACVQASVPAFIFCSSVDVAGPNSYKKIVLNGHEEQNHESTWSDPYPYSKKMAEKAVLAANGSMLKNGGTLNTCALRPMYIYGERSPFIFNAIIRALKNKGILCVTGKFSIANPVYVENVAWAHILAARGLRDPKKSTSIQGQFYYISDDTPHQSYDDLNYTLSKEWGLRPNASWSLPLPLLYWLAFLLETVSFLLRPVYRYRPLFNRHLITLSNSTFTFSYKKAQRDLGYEPLVNWEEAKQKTSEWIGTIVEQHREILDTKCQ
uniprot
proteins
ec_number
1.1.1.145
uniprot
proteins
ec_number
1.1.1.210
uniprot
proteins
ec_number
1.1.1.270
uniprot
proteins
ec_number
5.3.3.1
uniprot
proteins
function
FUNCTION: A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Expected to use NAD(+) as preferred electron donor for the 3-beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity. {ECO:0000250|UniProtKB:P14060, ECO:0000250|UniProtKB:P22071}.
uniprot
proteins
mass_dalton
42062
uniprot
proteins
pathway_participation
PATHWAY: Steroid hormone biosynthesis. {ECO:0000250|UniProtKB:P22071}.; PATHWAY: Steroid metabolism. {ECO:0000250|UniProtKB:P22071}.
uniprot
proteins
protein_family
3-beta-HSD family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1924345
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 288..308; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins