Cacna1d
entrez
12289
canonical
uniprot
Q99246
canonical
ensembl
ENSMUSG00000015968
resolver
ensp
ENSMUSP00000107869
resolver
ensp
ENSMUSP00000153250
resolver
ensp
ENSMUSP00000153293
resolver
ensp
ENSMUSP00000153586
resolver
ensp
ENSMUSP00000158632
resolver
ensp
ENSMUSP00000158773
resolver
ensp
ENSMUSP00000309971
resolver
ensp
ENSMUSP00000309972
resolver
enst
ENSMUST00000223803
resolver
enst
ENSMUST00000224785
resolver
genesymbol
Cacna1d
resolver
genesymbol_syn
Cach3
resolver
genesymbol_syn
Cacn4
resolver
genesymbol_syn
Cacnl1a2
resolver
genesymbol_syn
Cchl1a2
resolver
uniprot
A0A286YD72
resolver
uniprot
A0A589Q4M7
resolver
uniprot
Q7TSD2
resolver
uniprot
Q8R2I9
resolver
uniprot
Q8R2J0
resolver
uniprot_entry
A0A286YD72_MOUSE
resolver
uniprot_entry
A0A589Q4M7_MOUSE
resolver
uniprot_entry
CAC1D_MOUSE
resolver
uniprot_sec
Q7TSD2
resolver
uniprot_sec
Q8R2I9
resolver
uniprot_sec
Q8R2J0
resolver
amino_acid_sequence
MMMMMMMKKMQHQRQHQEDHANEANYARGTRLPISGEGPTSQPNSSKQTVLSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGETQGCCGTLWCWWKRRGAAKTGPSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEDAEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPSESETIPLPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEDSKPEEEDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSMPPASDTEKPLFPPAGNSGCHNHHNHNSIGKQAPTSTNANLNNANMSKAAHGKPPSIGNLEHVSENGHYSCKHDRELQRRSSIKRTRYYETYIRSESGDEQFPTICREDPEIHGYFRDPRCLGEQEYFSSEECCEDDSSPTWSRQNYNYYNRYPGSSMDFERPRGYHHPQGFLEDDDSPTGYDSRRSPRRRLLPPTPPSHRRSSFNFECLRRQSSQDDVLPSPALPHRAALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWSPCYTPLIQVDRSESMDQVNGSLPSLHRSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGSVCPRANGDMGPISHRQDYELQDFGPGYSDEEPDPGREEEDLADEMICITTL
uniprot
proteins
function
FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. {ECO:0000269|PubMed:16354915}.
uniprot
proteins
mass_dalton
247061
uniprot
proteins
protein_family
CACNA1D subfamily
uniprot
proteins
protein_family
Calcium channel alpha-1 subunit (TC 1.A.1.11) family
uniprot
proteins
pubmed
10929716
uniprot
proteins
pubmed
11581302
uniprot
proteins
pubmed
12700358
uniprot
proteins
pubmed
12900400
uniprot
proteins
pubmed
16354915
uniprot
proteins
pubmed
17947313
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2173707
uniprot
proteins
sequence_length
2179
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q01668}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 127..145; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 164..183; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 196..214; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 236..254; /note="Helical; Name=S4 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 274..293; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 382..406; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 544..563; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 579..597; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 606..624; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 635..653; /note="Helical; Name=S4 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 673..693; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 748..772; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 907..925; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 942..961; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 974..992; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 999..1018; /note="Helical; Name=S4 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1038..1057; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1148..1168; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1226..1244; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1260..1279; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1287..1308; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1334..1353; /note="Helical; Name=S4 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1373..1392; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1460..1484; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000255
uniprot
proteins