SLC6A11
entrez
6538
canonical
uniprot
P48066
canonical
ensembl
ENSG00000132164
resolver
ensp
ENSP00000254488
resolver
ensp
ENSP00000404120
resolver
ensp
ENSP00000796356
resolver
genesymbol
SLC6A11
resolver
genesymbol_syn
GABT3
resolver
genesymbol_syn
GAT3
resolver
hgnc
HGNC:11044
resolver
uniprot
B2R6U6
resolver
uniprot
Q8IYC9
resolver
uniprot_entry
S6A11_HUMAN
resolver
uniprot_sec
B2R6U6
resolver
uniprot_sec
Q8IYC9
resolver
activity_regulation
ACTIVITY REGULATION: GABA transport is inhibited by SNAP-5114. {ECO:0000269|PubMed:7874447}.
uniprot
proteins
amino_acid_sequence
MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAKLKSDGTIAAITEKETHF
uniprot
proteins
function
FUNCTION: Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:7874447). Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (By similarity). {ECO:0000250|UniProtKB:P31650, ECO:0000269|PubMed:7874447}.
uniprot
proteins
mass_dalton
70606
uniprot
proteins
protein_family
SLC6A11 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
7874447
uniprot
proteins
sequence_length
632
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P31647}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 59..79; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 87..106; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 131..151; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 226..244; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 253..270; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 306..323; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 335..356; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 389..408; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 438..456; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 473..493; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 514..533; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 553..571; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins