Dnm1
entrez
13429
canonical
uniprot
P39053
canonical
ensembl
ENSMUSG00000026825
resolver
ensp
ENSMUSP00000077461
resolver
ensp
ENSMUSP00000088618
resolver
ensp
ENSMUSP00000108977
resolver
ensp
ENSMUSP00000108992
resolver
ensp
ENSMUSP00000143955
resolver
ensp
ENSMUSP00000144264
resolver
ensp
ENSMUSP00000258030
resolver
ensp
ENSMUSP00000258032
resolver
ensp
ENSMUSP00000258035
resolver
ensp
ENSMUSP00000258043
resolver
ensp
ENSMUSP00000258044
resolver
ensp
ENSMUSP00000258046
resolver
ensp
ENSMUSP00000258083
resolver
enst
ENSMUST00000201433
resolver
genesymbol
Dnm1
resolver
genesymbol_syn
Dnm
resolver
genesymbol_syn
Kiaa4093
resolver
uniprot
A0A0J9YUN4
resolver
uniprot
A2AN50
resolver
uniprot
A2AN51
resolver
uniprot
A2AN54
resolver
uniprot
A2AN55
resolver
uniprot
Q3UNM1
resolver
uniprot
Q5DTN7
resolver
uniprot
Q61358
resolver
uniprot
Q61359
resolver
uniprot
Q61360
resolver
uniprot
Q6PDM5
resolver
uniprot
Q8JZZ4
resolver
uniprot
Q9CSY7
resolver
uniprot
Q9QXX1
resolver
uniprot_entry
A0A0J9YUN4_MOUSE
resolver
uniprot_entry
DYN1_MOUSE
resolver
uniprot_sec
A2AN50
resolver
uniprot_sec
A2AN51
resolver
uniprot_sec
A2AN54
resolver
uniprot_sec
A2AN55
resolver
uniprot_sec
Q3UNM1
resolver
uniprot_sec
Q5DTN7
resolver
uniprot_sec
Q61358
resolver
uniprot_sec
Q61359
resolver
uniprot_sec
Q61360
resolver
uniprot_sec
Q6PDM5
resolver
uniprot_sec
Q8JZZ4
resolver
uniprot_sec
Q9CSY7
resolver
uniprot_sec
Q9QXX1
resolver
amino_acid_sequence
MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVNSTTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKIAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVDEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPSLGAWRLNSPQGKHENRAGKARL
uniprot
proteins
ec_number
3.6.5.5
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks. Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis. Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission. May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR (By similarity). Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses (PubMed:35220002). Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (PubMed:35220002). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells. Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation (By similarity). {ECO:0000250|UniProtKB:Q05193, ECO:0000250|UniProtKB:Q08DF4, ECO:0000269|PubMed:35220002}.
uniprot
proteins
mass_dalton
97803
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-774 by GSK3B/GSK3-beta leads to inactivation of receptor-mediated endocytosis in non-neuronal cells. Dephosphorylation at Ser-774, through the EGFR downstream signaling, leads to activation and regulates early stages of clathrin-mediated endocytosis (CME) (By similarity). Phosphorylated on Tyr in response to EGF stimulation in cells expressing truncated EGFR (PubMed:11956154). Phosphorylated by CDK5 leading to synaptic vesicle endocytosis (SVE) activation (By similarity). {ECO:0000250|UniProtKB:P21575, ECO:0000250|UniProtKB:Q05193, ECO:0000269|PubMed:11956154}.
uniprot
proteins
protein_family
Dynamin/Fzo/YdjA family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
11042120
uniprot
proteins
pubmed
11082044
uniprot
proteins
pubmed
11956154
uniprot
proteins
pubmed
12456676
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16800626
uniprot
proteins
pubmed
17463283
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19781630
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
35220002
uniprot
proteins
pubmed
9143510
uniprot
proteins
sequence_length
867
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q05193}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q05193}. Cytoplasmic vesicle {ECO:0000269|PubMed:19781630}. Presynapse {ECO:0000250|UniProtKB:P21575}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250|UniProtKB:Q08DF4}. Note=Associated to the membrane in a helical polymer shape in a GTP bound state. Transiently recruited to endocytic clathrin-coated pits (CCPs) at a late stage of clathrin-coated vesicle (CCV) formation. {ECO:0000250|UniProtKB:Q05193}.
uniprot
proteins