HCAR3
entrez
8843
canonical
uniprot
P49019
canonical
ensembl
ENSG00000255398
resolver
ensp
ENSP00000436714
resolver
enst
ENST00000528880
resolver
genesymbol
HCAR3
resolver
genesymbol_syn
GPR109B
resolver
genesymbol_syn
HCA3
resolver
genesymbol_syn
HM74B
resolver
genesymbol_syn
NIACR2
resolver
hgnc
HGNC:16824
resolver
uniprot
A8K4G5
resolver
uniprot
B2R830
resolver
uniprot
E9PI97
resolver
uniprot
Q8NGE4
resolver
uniprot_entry
HCAR3_HUMAN
resolver
uniprot_sec
A8K4G5
resolver
uniprot_sec
B2R830
resolver
uniprot_sec
E9PI97
resolver
uniprot_sec
Q8NGE4
resolver
amino_acid_sequence
MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 3-hydroxyoctanoate, a fatty acid beta-oxidation intermediate. Signals through the inhibitory G(i)/o family of G proteins (PubMed:19561068, PubMed:37736747, PubMed:39427321). Acts as a negative feedback regulator of adipocyte lipolysis, helping to counterbalance prolipolytic signals during physiological or pathological elevations in beta-oxidation (PubMed:19561068). Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet (PubMed:12522134). {ECO:0000269|PubMed:12522134, ECO:0000269|PubMed:19561068, ECO:0000269|PubMed:37736747, ECO:0000269|PubMed:39427321}.
uniprot
proteins
mass_dalton
44478
uniprot
proteins
mutagenesis
MUTAGEN 86; /note="Y->A: Reduces the agonistic activity of Acifran."; /evidence="ECO:0000269|PubMed:37736747"; MUTAGEN 86; /note="Y->N: Increases the niacin binding affinity."; /evidence="ECO:0000269|PubMed:39427321"; MUTAGEN 93; /note="W->A: Loss of Acifran's agonistic activity."; /evidence="ECO:0000269|PubMed:37736747"; MUTAGEN 107; /note="F->A: Reduces the agonistic activity of Acifran."; /evidence="ECO:0000269|PubMed:37736747"; MUTAGEN 107; /note="F->L: Increases the niacin binding affinity."; /evidence="ECO:0000269|PubMed:39427321"; MUTAGEN 111; /note="R->A: Loss of agonistic activity of Acifran. Suppresses the activation effect of OH-octanoid acid."; /evidence="ECO:0000269|PubMed:19561068, ECO:0000269|PubMed:37736747"; MUTAGEN 279; /note="T->A: Inhibits activation mediated by OH-octanoid acid."; /evidence="ECO:0000269|PubMed:39427321"; MUTAGEN 284; /note="Y->A: Loss of Acifran's agonistic activity. Suppresses the activation effect of OH-octanoid acid."; /evidence="ECO:0000269|PubMed:37736747, ECO:0000269|PubMed:39427321
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12522134
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
19561068
uniprot
proteins
pubmed
21454438
uniprot
proteins
pubmed
37736747
uniprot
proteins
pubmed
39427321
uniprot
proteins
pubmed
7505609
uniprot
proteins
sequence_length
387
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37736747}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..50; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 64..85; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 195..209; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 237..256; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 274..298; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins