SLC16A7
entrez
9194
canonical
uniprot
O60669
canonical
ensembl
ENSG00000118596
resolver
ensp
ENSP00000261187
resolver
ensp
ENSP00000446722
resolver
ensp
ENSP00000448071
resolver
ensp
ENSP00000448742
resolver
ensp
ENSP00000449547
resolver
ensp
ENSP00000529002
resolver
ensp
ENSP00000529003
resolver
ensp
ENSP00000529004
resolver
ensp
ENSP00000529005
resolver
ensp
ENSP00000529006
resolver
ensp
ENSP00000529007
resolver
ensp
ENSP00000529008
resolver
ensp
ENSP00000529009
resolver
ensp
ENSP00000529010
resolver
ensp
ENSP00000529011
resolver
ensp
ENSP00000529012
resolver
ensp
ENSP00000529013
resolver
ensp
ENSP00000529014
resolver
ensp
ENSP00000529015
resolver
enst
ENST00000261187
resolver
enst
ENST00000547379
resolver
enst
ENST00000552024
resolver
enst
ENST00000552432
resolver
enst
ENST00000858944
resolver
enst
ENST00000858945
resolver
enst
ENST00000858946
resolver
enst
ENST00000858947
resolver
enst
ENST00000858948
resolver
enst
ENST00000858949
resolver
enst
ENST00000858950
resolver
enst
ENST00000858951
resolver
enst
ENST00000858952
resolver
enst
ENST00000858954
resolver
enst
ENST00000858956
resolver
genesymbol
SLC16A7
resolver
genesymbol_syn
MCT2
resolver
hgnc
HGNC:10928
resolver
uniprot
Q8NEM3
resolver
uniprot
Q9UPB3
resolver
uniprot_entry
MOT2_HUMAN
resolver
uniprot_sec
Q8NEM3
resolver
uniprot_sec
Q9UPB3
resolver
activity_regulation
ACTIVITY REGULATION: Transport activity exhibits steep dependence on substrate concentration (PubMed:32415067). Substrate concentration sensitivity of SLC16A7 arises from the strong inter-subunit cooperativity of the SLC16A7 dimer during transport (PubMed:32415067). Inhibited by AR-C155858 (PubMed:32415067). {ECO:0000269|PubMed:32415067}.
uniprot
proteins
amino_acid_sequence
MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAINYRLLAKERKEENARQKTRESEPLSKSKHSEDVNVKVSNAQSVTSERETNI
uniprot
proteins
function
FUNCTION: Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:32415067, PubMed:9786900). Dimerization is functionally required and both subunits work cooperatively in transporting substrate (PubMed:32415067). {ECO:0000269|PubMed:32415067, ECO:0000269|PubMed:9786900}.
uniprot
proteins
mass_dalton
52200
uniprot
proteins
mutagenesis
MUTAGEN 18; /note="W->A: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization. Dominant negative mutant."; /evidence="ECO:0000269|PubMed:32415067"; MUTAGEN 20; /note="W->A: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization. Dominant negative mutant."; /evidence="ECO:0000269|PubMed:32415067"; MUTAGEN 34; /note="Y->F: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization."; /evidence="ECO:0000269|PubMed:32415067"; MUTAGEN 38; /note="K->D: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization."; /evidence="ECO:0000269|PubMed:32415067"; MUTAGEN 70; /note="Y->A: No effect on protein abundance. Does not affect cell surface localization."; /evidence="ECO:0000269|PubMed:32415067"; MUTAGEN 143; /note="R->A: Reduces pyruvate transmembrane transporter activity. Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization. Dominant negative mutant."; /evidence="ECO:0000269|PubMed:32415067"; MUTAGEN 147; /note="N->A: Reduces pyruvate transmembrane transporter activity. Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization."; /evidence="ECO:0000269|PubMed:32415067"; MUTAGEN 262; /note="F->A: No effect on protein abundance. Does not affect cell surface localization."; /evidence="ECO:0000269|PubMed:32415067"; MUTAGEN 293; /note="D->N: Reduced proton-dependent active symport, but not pyruvate transport."; /evidence="ECO:0000269|PubMed:32415067"; MUTAGEN 297; /note="R->L,D: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization."; /evidence="ECO:0000269|PubMed:32415067"; MUTAGEN 305; /note="N->A: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization."; /evidence="ECO:0000269|PubMed:32415067"; MUTAGEN 351; /note="F->A: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization."; /evidence="ECO:0000269|PubMed:32415067"; MUTAGEN 355; /note="S->G,A: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization."; /evidence="ECO:0000269|PubMed:32415067"; MUTAGEN 360; /note="E->A: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization."; /evidence="ECO:0000269|PubMed:32415067
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15505343
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
32415067
uniprot
proteins
pubmed
9786900
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15505343, ECO:0000269|PubMed:32415067}; Multi-pass membrane protein {ECO:0000269|PubMed:32415067}. Basolateral cell membrane {ECO:0000250|UniProtKB:P53988}; Multi-pass membrane protein {ECO:0000269|PubMed:32415067}. Cytoplasm {ECO:0000250|UniProtKB:O70451}. Note=Requires the ancillary protein, EMB for plasma membrane localization (By similarity). Colocalizes with BSG in spermatozoa. Detected in the cytoplasm of Sertoli cells (By similarity). {ECO:0000250|UniProtKB:O70451, ECO:0000250|UniProtKB:Q63344}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 60..80; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 149..169; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 174..194; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 247..267; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 283..303; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 313..333; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 339..359; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 374..394; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins