CAMKK2
entrez
10645
canonical
uniprot
Q96RR4
canonical
ensembl
ENSG00000110931
resolver
ensp
ENSP00000312741
resolver
ensp
ENSP00000321230
resolver
ensp
ENSP00000336634
resolver
ensp
ENSP00000376265
resolver
ensp
ENSP00000376266
resolver
ensp
ENSP00000384600
resolver
ensp
ENSP00000388273
resolver
ensp
ENSP00000388368
resolver
ensp
ENSP00000445944
resolver
ensp
ENSP00000577186
resolver
ensp
ENSP00000577188
resolver
ensp
ENSP00000643584
resolver
ensp
ENSP00000643586
resolver
ensp
ENSP00000643587
resolver
ensp
ENSP00000643588
resolver
ensp
ENSP00000643592
resolver
ensp
ENSP00000643599
resolver
ensp
ENSP00000688668
resolver
ensp
ENSP00000688677
resolver
ensp
ENSP00000688678
resolver
genesymbol
CAMKK2
resolver
genesymbol_syn
CAMKKB
resolver
genesymbol_syn
KIAA0787
resolver
hgnc
HGNC:1470
resolver
uniprot
A8K7Q7
resolver
uniprot
O94883
resolver
uniprot
Q8IUG2
resolver
uniprot
Q8IUG3
resolver
uniprot
Q8N3I4
resolver
uniprot
Q8WY03
resolver
uniprot
Q8WY04
resolver
uniprot
Q8WY05
resolver
uniprot
Q8WY06
resolver
uniprot
Q96RP1
resolver
uniprot
Q96RP2
resolver
uniprot
Q96RR3
resolver
uniprot
Q9BWE9
resolver
uniprot
Q9UER3
resolver
uniprot
Q9UES2
resolver
uniprot
Q9Y5N2
resolver
uniprot_entry
KKCC2_HUMAN
resolver
uniprot_sec
A8K7Q7
resolver
uniprot_sec
O94883
resolver
uniprot_sec
Q8IUG2
resolver
uniprot_sec
Q8IUG3
resolver
uniprot_sec
Q8N3I4
resolver
uniprot_sec
Q8WY03
resolver
uniprot_sec
Q8WY04
resolver
uniprot_sec
Q8WY05
resolver
uniprot_sec
Q8WY06
resolver
uniprot_sec
Q96RP1
resolver
uniprot_sec
Q96RP2
resolver
uniprot_sec
Q96RR3
resolver
uniprot_sec
Q9BWE9
resolver
uniprot_sec
Q9UER3
resolver
uniprot_sec
Q9UES2
resolver
uniprot_sec
Q9Y5N2
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca(2+)/calmodulin. In part, activity is independent on Ca(2+)/calmodulin (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEPGCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKEARQRRQPPGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}.
uniprot
proteins
mass_dalton
64746
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation. {ECO:0000269|PubMed:21957496}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
11395482
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12935886
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
21957496
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9662074
uniprot
proteins
pubmed
9822657
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21957496}. Cytoplasm {ECO:0000269|PubMed:21957496}. Cell projection, neuron projection {ECO:0000269|PubMed:21957496}. Note=Predominantly nuclear in unstimulated cells, relocalizes into cytoplasm and neurites after forskolin induction. {ECO:0000269|PubMed:21957496}.
uniprot
proteins