PALLD
entrez
23022
canonical
uniprot
Q8WX93
canonical
ensembl
ENSG00000129116
resolver
ensp
ENSP00000261509
resolver
ensp
ENSP00000424016
resolver
ensp
ENSP00000425556
resolver
ensp
ENSP00000426947
resolver
ensp
ENSP00000516055
resolver
enst
ENST00000704822
resolver
genesymbol
PALLD
resolver
genesymbol_syn
KIAA0992
resolver
hgnc
HGNC:17068
resolver
uniprot
A0A994J7A4
resolver
uniprot
B2RTX2
resolver
uniprot
B3KTG2
resolver
uniprot
B5MD56
resolver
uniprot
B7ZMM5
resolver
uniprot
Q7L3E0
resolver
uniprot
Q7Z3W0
resolver
uniprot
Q86WE8
resolver
uniprot
Q8N1M2
resolver
uniprot
Q9UGA0
resolver
uniprot
Q9UQF5
resolver
uniprot
Q9Y2J6
resolver
uniprot
Q9Y3E9
resolver
uniprot_entry
A0A994J7A4_HUMAN
resolver
uniprot_entry
B2RTX2_HUMAN
resolver
uniprot_entry
PALLD_HUMAN
resolver
uniprot_sec
B3KTG2
resolver
uniprot_sec
B5MD56
resolver
uniprot_sec
B7ZMM5
resolver
uniprot_sec
Q7L3E0
resolver
uniprot_sec
Q7Z3W0
resolver
uniprot_sec
Q86WE8
resolver
uniprot_sec
Q8N1M2
resolver
uniprot_sec
Q9UGA0
resolver
uniprot_sec
Q9UQF5
resolver
uniprot_sec
Q9Y2J6
resolver
uniprot_sec
Q9Y3E9
resolver
amino_acid_sequence
MSGTSSHESFYDSLSDMQEESKNTDFFPGLSAFLSQEEINKSLDLARRAIADSETEDFDSEKEISQIFSTSPASLCEHPSHKETKLGEHASRRPQDNRSTPVQPLAEKQTKSISSPVSKRKPAMSPLLTRPSYIRSLRKAEKRGAKTPSTNVKPKTPHQRKGGPQSQLCDKAANLIEELTSIFKAAKPRNRSPNGESSSPDSGYLSPKNQPSALLSASASQSPMEDQGEMEREVKSPGARHCYQDNQDLAVPHNRKSHPQPHSALHFPAAPRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELHNTPDIQIHCEGGDLHTLIIAEAFEDDTGRYTCLATNPSGSDTTSAEVFIEGASSTDSDSESLAFKSRAGAMPQAQKKTTSVSLTIGSSSPKTGVTTAVIQPLSVPVQQVHSPTSYLCRPDGTTTAYFPPVFTKELQNTAVAEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAEPEEICTLVIAETFPEDAGIFTCSARNDYGSATSTAQLVVTSANTENCSYESMGESNNDHFQHFPPPPPILETSSLELASKKPSEIQQVNNPELGLSRAALQMQFNAAERETNGVHPSRGVNGLINGKANSNKSLPTPAVLLSPTKEPPPLLAKPKLDPLKLQQLQNQIRLEQEAGARQPPPAPRSAPPSPPFPPPPAFPELAACTPPASPEPMSALASRSAPAMQSSGSFNYARPKQFIAAQNLGPASGHGTPASSPSSSSLPSPMSPTPRQFGRAPVPPFAQPFGAEPEAPWGSSSPSPPPPPPPVFSPTAAFPVPDVFPLPPPPPPLPSPGQASHCSSPATRFGHSQTPAAFLSALLPSQPPPAAVNALGLPKGVTPAGFPKKASRTARIASDEEIQGTKDAVIQDLERKLRFKEDLLNNGQPRLTYEERMARRLLGADSATVFNIQEPEEETANQEYKVSSCEQRLISEIEYRLERSPVDESGDEVQYGDVPVENGMAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQGRISCTGRLMVQAVNQRGRSPRSPSGHPHVRRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDVYTQWHQQSQSTKPKKVRPSASRYAALSDQGLDIKAAFQPEANPSHLTLNTALVESEDL
uniprot
proteins
disease_involvement
DISEASE: Pancreatic cancer 1 (PNCA1) [MIM:606856]: A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue. {ECO:0000269|PubMed:17194196, ECO:0000269|PubMed:17415588, ECO:0000269|PubMed:17455999}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Note=Genetic variations in PALLD may be associated with susceptibility to myocardial infarction. {ECO:0000269|PubMed:16175505}.
uniprot
proteins
function
FUNCTION: Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}.
uniprot
proteins
mass_dalton
150564
uniprot
proteins
post_translational_modification
PTM: Phosphorylated predominantly on serines and, to a lesser extent, on tyrosines (By similarity). Phosphorylation at Ser-1118 by PKB/AKT1 modulates cytoskeletal organization and cell motility. {ECO:0000250, ECO:0000269|PubMed:17537434, ECO:0000269|PubMed:20471940}.
uniprot
proteins
protein_family
Myotilin/palladin family
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11598191
uniprot
proteins
pubmed
12601173
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15147863
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16125169
uniprot
proteins
pubmed
16175505
uniprot
proteins
pubmed
16367745
uniprot
proteins
pubmed
16754980
uniprot
proteins
pubmed
16794588
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17194196
uniprot
proteins
pubmed
17322171
uniprot
proteins
pubmed
17415588
uniprot
proteins
pubmed
17455999
uniprot
proteins
pubmed
17537434
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20471940
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
1383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:17322171, ECO:0000269|PubMed:17537434}. Cell junction, focal adhesion {ECO:0000269|PubMed:17322171}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:16125169}. Cell projection, ruffle {ECO:0000269|PubMed:17537434}. Cell projection, podosome {ECO:0000250|UniProtKB:P0C5E3}. Cell projection, lamellipodium {ECO:0000269|PubMed:17537434}. Cell projection, axon {ECO:0000250|UniProtKB:P0C5E3}. Cell projection, growth cone {ECO:0000250|UniProtKB:P0C5E3}. Note=Localizes to stress fibers and Z lines (PubMed:11598191, PubMed:16125169, PubMed:17322171, PubMed:17537434). Preferentially expressed in the excitatory presynaptic terminals (By similarity). {ECO:0000250|UniProtKB:P0C5E3, ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:16125169, ECO:0000269|PubMed:17322171, ECO:0000269|PubMed:17537434}.
uniprot
proteins