Sox7
entrez
20680
canonical
uniprot
P40646
canonical
ensembl
ENSMUSG00000063060
resolver
ensp
ENSMUSP00000078597
resolver
enst
ENSMUST00000079652
resolver
genesymbol
Sox7
resolver
genesymbol_syn
Sox-7
resolver
uniprot
Q3U1W5
resolver
uniprot
Q9R1T6
resolver
uniprot_entry
Q3U1W5_MOUSE
resolver
uniprot_entry
SOX7_MOUSE
resolver
uniprot_sec
Q9R1T6
resolver
amino_acid_sequence
MASLLGAYPWTEGLECPALEAELSDGLSPPAVPRPSGDKSSESRIRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALTLSQKRPYVDEAERLRLQHMQDYPNYKYRPRRKKQGKRLCKRVDPGFLLSSLSRDQNTLPEKNGIGRGEKEDRGEYSPGATLPGLHSCYREGAAAAPGSVDTYPYGLPTPPEMSPLDALEPEQTFFSSSCQEEHGHPHHLPHLPGPPYSPEFTPSPLHCSHPLGSLALGQSPGVSMMSSVSGCPPSPAYYSHATYHPLHPNLQAHLGQLSPPPEHPGFDTLDQLSQVELLGDMDRNEFDQYLNTPGHPDSAAGVGTLTGHVPLSQGTPTGPTETSLISVLADATATYYNSYSVS
uniprot
proteins
function
FUNCTION: Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors. May be required for the survival of both hematopoietic and endothelial precursors during specification. May play a role in skeletal myogenesis and up-regulate the expression of muscle markers, such as PAX3/PAX7 and Meox1. Competes with GATA4 for binding and activation of the FGF3 promoter. Represses Wnt/beta-catenin-stimulated transcription. Probably acts by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. {ECO:0000269|PubMed:10320775, ECO:0000269|PubMed:11691915, ECO:0000269|PubMed:15082719, ECO:0000269|PubMed:19489079, ECO:0000269|PubMed:19801444, ECO:0000269|PubMed:22492353}.
uniprot
proteins
mass_dalton
41489
uniprot
proteins
mutagenesis
MUTAGEN 323..328; /note="Missing: Loss of beta-catenin-binding."; /evidence="ECO:0000269|PubMed:11691915
uniprot
proteins
pubmed
10320775
uniprot
proteins
pubmed
11691915
uniprot
proteins
pubmed
15082719
uniprot
proteins
pubmed
1614875
uniprot
proteins
pubmed
19489079
uniprot
proteins
pubmed
19801444
uniprot
proteins
pubmed
22492353
uniprot
proteins
sequence_length
380
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:11691915}. Cytoplasm {ECO:0000269|PubMed:11691915}.
uniprot
proteins