SLC17A4
entrez
10050
canonical
uniprot
Q9Y2C5
canonical
ensembl
ENSG00000146039
resolver
ensp
ENSP00000367137
resolver
ensp
ENSP00000391345
resolver
ensp
ENSP00000537646
resolver
ensp
ENSP00000537649
resolver
ensp
ENSP00000537651
resolver
ensp
ENSP00000537652
resolver
ensp
ENSP00000537657
resolver
ensp
ENSP00000537659
resolver
ensp
ENSP00000627077
resolver
ensp
ENSP00000654713
resolver
ensp
ENSP00000654718
resolver
ensp
ENSP00000654723
resolver
genesymbol
SLC17A4
resolver
hgnc
HGNC:10932
resolver
uniprot
B4DDV9
resolver
uniprot
E7EPE8
resolver
uniprot
E7EU17
resolver
uniprot
Q32MB7
resolver
uniprot
Q32MB8
resolver
uniprot_entry
S17A4_HUMAN
resolver
uniprot_sec
B4DDV9
resolver
uniprot_sec
E7EPE8
resolver
uniprot_sec
E7EU17
resolver
uniprot_sec
Q32MB7
resolver
uniprot_sec
Q32MB8
resolver
amino_acid_sequence
MSTGPDVKATVGDISSDGNLNVAQEECSRKGFCSVRHGLALILQLCNFSIYTQQMNLSIAIPAMVNNTAPPSQPNASTERPSTDSQGYWNETLKEFKAMAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAGVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPFISAGEKRYIVCSLAQQDCSPGWSLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRKILRLITIRKLFTAIGVLFPSVILVSLPWVRSSHSMTMTFLVLSSAISSFCESGALVNFLDIAPRYTGFLKGLLQVFAHIAGAISPTAAGFFISQDSEFGWRNVFLLSAAVNISGLVFYLIFGRADVQDWAKEQTFTHL
uniprot
proteins
function
FUNCTION: Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions (PubMed:22460716). Mediates chloride-dependent transport of urate (PubMed:22460716). Mediates sodium-independent high affinity transport of thyroid hormones including L-thyroxine (T4) and 3,3',5-triiodo-L-thyronine (T3) (PubMed:30367059, PubMed:34937426). Can actively transport inorganic phosphate into cells via Na(+) cotransport (PubMed:22460716). {ECO:0000269|PubMed:22460716, ECO:0000269|PubMed:30367059, ECO:0000269|PubMed:34937426}.
uniprot
proteins
mass_dalton
54055
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="N->A: Loss of glycosylation and significant reduction in the transport of thyroid hormones T3 and T4; when associated with A-75 and A-90."; /evidence="ECO:0000269|PubMed:34937426"; MUTAGEN 75; /note="N->A: Loss of glycosylation and significant reduction in the transport of thyroid hormones T3 and T4; when associated with A-66 and A-90."; /evidence="ECO:0000269|PubMed:34937426"; MUTAGEN 90; /note="N->A: Loss of glycosylation and significant reduction in the transport of thyroid hormones T3 and T4; when associated with A-75 and A-90."; /evidence="ECO:0000269|PubMed:34937426
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sodium/anion cotransporter family
uniprot
proteins
pubmed
10319585
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22460716
uniprot
proteins
pubmed
30367059
uniprot
proteins
pubmed
34937426
uniprot
proteins
sequence_length
497
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:22460716}; Multi-pass membrane protein {ECO:0000255}. Note=Apical in the intestinal brush border. {ECO:0000269|PubMed:22460716}.
uniprot
proteins
transmembrane_region
TRANSMEM 149..169; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 171..191; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 230..250; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 292..312; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 332..352; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 368..388; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 398..418; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 431..451; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 461..481; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins