Jup
entrez
16480
canonical
uniprot
Q02257
canonical
ensembl
ENSMUSG00000001552
resolver
ensp
ENSMUSP00000001592
resolver
ensp
ENSMUSP00000103026
resolver
ensp
ENSMUSP00000303348
resolver
ensp
ENSMUSP00000303350
resolver
ensp
ENSMUSP00000340550
resolver
enst
ENSMUST00000001592
resolver
enst
ENSMUST00000107403
resolver
genesymbol
Jup
resolver
uniprot
Q8CGD3
resolver
uniprot_entry
PLAK_MOUSE
resolver
uniprot_sec
Q8CGD3
resolver
amino_acid_sequence
MEVMNLIEQPIKVTEWQQTYTYDSGIHSGVNTCVPSVSSKGIMDEDDACGRQYTLKKTTTYTQGVPQNQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQTTNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQGLVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYADDMDATYRPMYSSDVPLDPLDMHMDLDGDYPMDTYSDGLRPPYPTADHMLA
uniprot
proteins
function
FUNCTION: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (PubMed:25496840). {ECO:0000269|PubMed:19015309, ECO:0000269|PubMed:25496840}.
uniprot
proteins
mass_dalton
81801
uniprot
proteins
post_translational_modification
PTM: Cleaved by CASP3 in response to apoptosis. {ECO:0000250|UniProtKB:P14923}.; PTM: May be phosphorylated by FER. {ECO:0000250}.
uniprot
proteins
protein_family
Beta-catenin family
uniprot
proteins
pubmed
1509266
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16325582
uniprot
proteins
pubmed
19015309
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22515648
uniprot
proteins
pubmed
25496840
uniprot
proteins
pubmed
27033150
uniprot
proteins
pubmed
34905516
uniprot
proteins
pubmed
38395410
uniprot
proteins
pubmed
7982500
uniprot
proteins
sequence_length
745
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000250|UniProtKB:P14923}. Cell junction, desmosome {ECO:0000269|PubMed:22515648, ECO:0000269|PubMed:38395410}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P14923}. Cell membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:P14923}. Cytoplasm {ECO:0000250|UniProtKB:Q9PVF7}. Cell junction {ECO:0000250|UniProtKB:Q9PVF7}. Nucleus {ECO:0000250|UniProtKB:Q9PVF7}. Cell projection, axon {ECO:0000269|PubMed:25496840}. Note=Cytoplasmic in a soluble and membrane-associated form. Colocalizes with DSG4 at desmosomes (By similarity). {ECO:0000250|UniProtKB:P14923}.
uniprot
proteins