KLHL21
entrez
9903
canonical
uniprot
Q9UJP4
canonical
ensembl
ENSG00000162413
resolver
ensp
ENSP00000366886
resolver
ensp
ENSP00000652087
resolver
genesymbol
KLHL21
resolver
genesymbol_syn
KIAA0469
resolver
hgnc
HGNC:29041
resolver
uniprot
B3KQP2
resolver
uniprot
O75057
resolver
uniprot
Q5SY26
resolver
uniprot
Q5SY28
resolver
uniprot
Q8N4I6
resolver
uniprot
Q8NF10
resolver
uniprot_entry
KLH21_HUMAN
resolver
uniprot_sec
B3KQP2
resolver
uniprot_sec
O75057
resolver
uniprot_sec
Q5SY26
resolver
uniprot_sec
Q5SY28
resolver
uniprot_sec
Q8N4I6
resolver
uniprot_sec
Q8NF10
resolver
amino_acid_sequence
MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQTFSGGRGFELDSGSDDMDPGRPRPPRDPDELH
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:19995937}.
uniprot
proteins
mass_dalton
66617
uniprot
proteins
mutagenesis
MUTAGEN 114..117; /note="DLLQ->AALA: Abolishes interaction with CUL3."; /evidence="ECO:0000269|PubMed:19995937
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
14528312
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19995937
uniprot
proteins
pubmed
9455484
uniprot
proteins
sequence_length
597
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19995937}. Note=Localizes to the spindle midzone and targets CUL3 to this region.
uniprot
proteins