CHP2
entrez
63928
canonical
uniprot
O43745
canonical
ensembl
ENSG00000166869
resolver
ensp
ENSP00000300113
resolver
enst
ENST00000300113
resolver
genesymbol
CHP2
resolver
genesymbol_syn
HCA520
resolver
hgnc
HGNC:24927
resolver
uniprot
A8K2I8
resolver
uniprot_entry
CHP2_HUMAN
resolver
uniprot_sec
A8K2I8
resolver
amino_acid_sequence
MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVNPLGDRIIESFFPDGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNSRRNKLHYAFQLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRTVQEADEDGDGAVSFVEFTKSLEKMDVEQKMSIRILK
uniprot
proteins
function
FUNCTION: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. {ECO:0000269|PubMed:12226101, ECO:0000269|PubMed:18815128}.
uniprot
proteins
mass_dalton
22452
uniprot
proteins
mutagenesis
MUTAGEN 50; /note="D->A: Does not reduce calcium-binding."; /evidence="ECO:0000269|PubMed:21392185"; MUTAGEN 82; /note="G->A: Does not reduce calcium-binding."; /evidence="ECO:0000269|PubMed:21392185"; MUTAGEN 135; /note="E->A: Reduces calcium-binding. Inhibits calcium-binding and cell membrane localization; when associated with A-176."; /evidence="ECO:0000269|PubMed:21392185"; MUTAGEN 137..148; /note="LQVLRLMVGVQV->AQVARAMAGAQA: Localizes in the nucleus and increases cell proliferation."; /evidence="ECO:0000269|PubMed:21392185"; MUTAGEN 176; /note="E->A: Reduces calcium-binding. Inhibits calcium-binding and cell membrane localization; when associated with A-135."; /evidence="ECO:0000269|PubMed:21392185
uniprot
proteins
protein_family
CHP subfamily
uniprot
proteins
protein_family
Calcineurin regulatory subunit family
uniprot
proteins
pubmed
12097419
uniprot
proteins
pubmed
12226101
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16511206
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16710297
uniprot
proteins
pubmed
18815128
uniprot
proteins
pubmed
21392185
uniprot
proteins
sequence_length
196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21392185}. Cytoplasm {ECO:0000269|PubMed:21392185}. Cell membrane {ECO:0000269|PubMed:21392185}. Note=Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. {ECO:0000250}.
uniprot
proteins