Tk1
entrez
21877
canonical
uniprot
P04184
canonical
ensembl
ENSMUSG00000025574
resolver
ensp
ENSMUSP00000026661
resolver
genesymbol
Tk1
resolver
genesymbol_syn
Tk-1
resolver
uniprot
Q58EU0
resolver
uniprot
Q8C3P8
resolver
uniprot
Q921J8
resolver
uniprot_entry
KITH_MOUSE
resolver
uniprot_sec
Q58EU0
resolver
uniprot_sec
Q8C3P8
resolver
uniprot_sec
Q921J8
resolver
amino_acid_sequence
MSYINLPTVLPSSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSNSFSTHDRNTMDALPACMLRDVTQESLGVAVIGIDEGQFFPDIVDFCEMMANEGKTVIVAALDGTFQRKAFGSILNLVPLAESVVKLTAVCMECFREAAYTKRLGLEKEVEVIGGADKYHSVCRLCYFKKSSAQTAGSDNKNCLVLGQPGEALVVRKLFASQQVLQYNSAN
uniprot
proteins
ec_number
2.7.1.21
uniprot
proteins
function
FUNCTION: Cell-cycle-regulated enzyme of importance in nucleotide metabolism. Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate. Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration. {ECO:0000250|UniProtKB:P04183}.
uniprot
proteins
mass_dalton
25776
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-13 in mitosis. Phosphorylation of Ser-13 by CDK1 during mitosis reduces homotetramerization and catalytic efficiency when DNA replication is complete and intracellular TK1 is still present at a high level. {ECO:0000250|UniProtKB:P04183}.; PTM: Polyubiquitinated. Postmitosis, ubiquitination leads to proteasomal degradation. The KEN box sequence located at the C-terminal region targets for degradation by the anaphase promoting complex (APC/C) activated and rate-limited by FZR1. {ECO:0000250|UniProtKB:P04183}.
uniprot
proteins
protein_family
Thymidine kinase family
uniprot
proteins
pubmed
1496920
uniprot
proteins
pubmed
1511894
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1762910
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
3018504
uniprot
proteins
pubmed
3244356
uniprot
proteins
pubmed
7681542
uniprot
proteins
sequence_length
233
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins