Il34
entrez
76527
canonical
uniprot
Q8R1R4
canonical
ensembl
ENSMUSG00000031750
resolver
ensp
ENSMUSP00000076120
resolver
ensp
ENSMUSP00000114398
resolver
genesymbol
Il34
resolver
uniprot
B2ZC71
resolver
uniprot
B2ZC72
resolver
uniprot
Q9D8F2
resolver
uniprot_entry
IL34_MOUSE
resolver
uniprot_sec
B2ZC71
resolver
uniprot_sec
B2ZC72
resolver
uniprot_sec
Q9D8F2
resolver
amino_acid_sequence
MPWGLAWLYCLGILLDVALGNENLEIWTLTQDKECDLTGYLRGKLQYKNRLQYMKHYFPINYRIAVPYEGVLRVANITRLQKAHVSERELRYLWVLVSLNATESVMDVLLEGHPSWKYLQEVQTLLENVQRSLMDVEIGPHVEAVLSLLSTPGLSLKLVRPKALLDNCFRVMELLYCSCCKQSPILKWQDCELPRLHPHSPGSLMQCTATNVYPLSRQTPTSLPGSPSSSHGSLP
uniprot
proteins
function
FUNCTION: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
26764
uniprot
proteins
protein_family
IL-34 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18467591
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins