Stimate
entrez
361110
canonical
uniprot
Q7TSW6
canonical
ensembl
ENSRNOG00000017051
resolver
ensembl
ENSRNOG00055021131
resolver
ensembl
ENSRNOG00060013845
resolver
ensembl
ENSRNOG00065015199
resolver
ensp
ENSRNOP00000023314
resolver
ensp
ENSRNOP00055029310
resolver
ensp
ENSRNOP00060018800
resolver
ensp
ENSRNOP00065019714
resolver
enst
ENSRNOT00000023314
resolver
enst
ENSRNOT00055036098
resolver
enst
ENSRNOT00060023648
resolver
enst
ENSRNOT00065025174
resolver
genesymbol
Stimate
resolver
genesymbol_syn
Tmem110
resolver
uniprot_entry
STIMA_RAT
resolver
amino_acid_sequence
MQGPGGNVSRGLPGGPASTVASGAGRCESGALMHSFGIFLQGLLGVVAFSTLMLKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVGVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNAFMFWVVDNFLMRKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDAEEDLRRPVKKKHRFGLPV
uniprot
proteins
function
FUNCTION: Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1, promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store-dependent ER-PM junctions. {ECO:0000250|UniProtKB:Q86TL2}.
uniprot
proteins
mass_dalton
32470
uniprot
proteins
protein_family
STIMATE family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q86TL2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q86TL2}. Note=Colocalizes with STIM1 at ER-plasma membrane (ER-PM) junctions, also called cortical endoplasmic reticulum (ER), in store-depleted calcium cells. May translocate to ER-PM junctions in a STIM1-dependent manner in store-depleted cells. {ECO:0000250|UniProtKB:Q86TL2}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..49; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 156..176; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 194..214; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins