Ankrd9
entrez
74251
canonical
uniprot
Q8BH83
canonical
ensembl
ENSMUSG00000037904
resolver
ensp
ENSMUSP00000048823
resolver
ensp
ENSMUSP00000119339
resolver
ensp
ENSMUSP00000120816
resolver
ensp
ENSMUSP00000121279
resolver
ensp
ENSMUSP00000123239
resolver
ensp
ENSMUSP00000323640
resolver
ensp
ENSMUSP00000323646
resolver
ensp
ENSMUSP00000323654
resolver
enst
ENSMUST00000043459
resolver
enst
ENSMUST00000128353
resolver
enst
ENSMUST00000135131
resolver
enst
ENSMUST00000140788
resolver
enst
ENSMUST00000148765
resolver
genesymbol
Ankrd9
resolver
uniprot
Q3TA09
resolver
uniprot
Q8BHR3
resolver
uniprot_entry
ANKR9_MOUSE
resolver
uniprot_sec
Q3TA09
resolver
uniprot_sec
Q8BHR3
resolver
amino_acid_sequence
MPWDTRPGRSANGGPEGPGAARLRVQKQCRKSSFAFYLAVRDQLPVWLLEDIRASEAFHCDERGRAAAYSPSEALLYALVHDHQAYAHYLLATFPRCALAPPSAGFRCCTAPGPHVALAVRYNRVGILRRILRTVQDFPVEERVRLLDRRGCSRVEGGGTSLHVACELARPECLFLLLGHGASPGLRDGSGFTPLELLLRQLNQDASSAPTKAEAASATVNAATANTTSSEEVCQRRLLLLDLLVLYTPGGVVGPARCELLGDQLRWQRLLGEDKFQWLAGLAPPSLFVRAMQVLVTTISPGRFPEALDELPLPSFLQPLDLTGKG
uniprot
proteins
function
FUNCTION: Substrate receptor subunit of a cullin-RING superfamily E3 ligase complex (CUL5-based E3 ubiquitin ligase complex) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Depending of the metabolic state of the cell, promotes the proteasomal degradation of IMPDH2, the rate-limiting enzyme in GTP biosynthesis or protects IMPDH2 by stabilizing IMPDH2 filaments assembly. Implicated in different cellular processes, like copper homeostasis and cell proliferation. {ECO:0000250|UniProtKB:Q96BM1}.
uniprot
proteins
mass_dalton
35513
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q96BM1}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q96BM1}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q96BM1}. Note=Detected in long filamentous cytosolic structures where it colocalizes with IMPDH2. Under basal conditions ANKRD9 is mainly in vesicle-like structures, upon nutrient limitation (guanine nucleotides deficiency) ANKRD9 loses its vesicular pattern and assembles with IMPDH2 into rodlike filaments. {ECO:0000250|UniProtKB:Q96BM1}.
uniprot
proteins