Tns4
entrez
217169
canonical
uniprot
Q8BZ33
canonical
ensembl
ENSMUSG00000017607
resolver
ensp
ENSMUSP00000017751
resolver
enst
ENSMUST00000017751
resolver
genesymbol
Tns4
resolver
uniprot
A2A552
resolver
uniprot
Q3TCM8
resolver
uniprot
Q7TNR5
resolver
uniprot_entry
TENS4_MOUSE
resolver
uniprot_sec
A2A552
resolver
uniprot_sec
Q3TCM8
resolver
uniprot_sec
Q7TNR5
resolver
amino_acid_sequence
MSSSLLAGGHMVSLTPCEESRMALHPTPSPGLPALCPYYTTESWGTQPLMAPTLRKGSSDRLQQAQQAEARAHCLLQGPGEQASGASQDLESCIDFSLEALNQMILEIDPTFQLLPSGTAGPQAESTNSIMSRNKKEEPEALDIKYIEVTSTRSRYLDGPQRCSSPCATPPFGSPRSGSLFLSRDIPRETRSSSNESLIFSGNQGRGPSPLTPSSLSNAIPCRESRTSGSPLATPPGWEKGLRAPQRGSRVSILSASPVSDVSYVFGSNQSLPHSSLSSYPSSSRSLGSPASSSSSLHSLDRGSQCGRPSDAQAPSNPILGMGQPQAVQSTPVAKEQASSCPASVTNSMADIPIVLINGSPEPQSPPAQRTPGHQDSVQSRVTSPSHLCQAIKSPSKTLPDVPLPASPDGPAKDMQPTMKFVMDTSKYWFKPSITREQAINLLRTEKPGAFVIRDSSSYRGSFGLALKVQETSASAPNRPGEDSSDLIRHFLIESSAKGVHLKGADEEPYFGSLSSFVCQHSIMALALPCKLTIPQKELGGAEPASDSPTHGQTSCLKISAGCHTLYLSSVSVETLSGALAVQKAISVTLERDVLPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLSALRFCGMDPEQRKWQKYCKPSRIFGFVAKSQTEPQENVCHLFAEYDAVQPASQVISLVTALLQDTERM
uniprot
proteins
function
FUNCTION: Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration. Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF. Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration. {ECO:0000250|UniProtKB:Q8IZW8}.
uniprot
proteins
mass_dalton
74622
uniprot
proteins
protein_family
PTEN phosphatase protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
696
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q8IZW8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8IZW8}.
uniprot
proteins