Dyrk3
entrez
304775
canonical
uniprot
Q4V8A3
canonical
ensembl
ENSRNOG00000004870
resolver
ensembl
ENSRNOG00055020331
resolver
ensembl
ENSRNOG00060014900
resolver
ensembl
ENSRNOG00065020809
resolver
ensp
ENSRNOP00000006502
resolver
ensp
ENSRNOP00055028146
resolver
ensp
ENSRNOP00060020313
resolver
ensp
ENSRNOP00065028402
resolver
enst
ENSRNOT00000006502
resolver
enst
ENSRNOT00055034724
resolver
enst
ENSRNOT00060025480
resolver
enst
ENSRNOT00065035290
resolver
genesymbol
Dyrk3
resolver
uniprot_entry
DYRK3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Protein kinase activity is activated following autophosphorylation at Tyr-368. {ECO:0000250|UniProtKB:O43781}.
uniprot
proteins
amino_acid_sequence
MGGAARERGRKDAALPGAGLPPQQRRLGDGVYDTFMMIDETKCPPYTNTLCNPSEAPVSRRLNITTEPFTRGHTQHFVSGGVMKVEQLFQEFGSRRTSTLQSDGVSNSEKSSPASQGKSSDSLGTVKCSLSSRPSKVLPLTPEQALKQYKHHLTAYEKLEIISYPEIYFVGPNAKKRQGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPQKLLEQSKRAKYFINSKGLPRYCSVTTQTDGRVVLLGGRSRRGKKRGPPGSKDWAAALKGCDDYLFIEFLKRCLQWDPSARLTPAQALRHPWISKSAPRPLTTDKVSGKRVVNPTNAFQGLGSKLPPVVGIASKLKANLMSETSGSIPLCSVLPKLIS
uniprot
proteins
ec_number
2.7.12.1
uniprot
proteins
function
FUNCTION: Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material. Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues. Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1. Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3. Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis. Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling. When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling. Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis. {ECO:0000250|UniProtKB:O43781}.
uniprot
proteins
mass_dalton
65511
uniprot
proteins
post_translational_modification
PTM: Protein kinase activity is activated following autophosphorylation at Tyr-368. {ECO:0000250|UniProtKB:Q922Y0}.; PTM: Ubiquitinated at anaphase by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:O43781}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MNB/DYRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17292540
uniprot
proteins
pubmed
9748265
uniprot
proteins
sequence_length
586
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43781}. Cytoplasm {ECO:0000250|UniProtKB:O43781}. Nucleus speckle {ECO:0000250|UniProtKB:O43781}. Cytoplasmic granule {ECO:0000250|UniProtKB:O43781}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O43781}. Note=Associates with membraneless organelles in the cytoplasm and nucleus. Shuttles between cytoplasm and stress granules. Localized predominantly on distinct speckles distributed throughout the cytoplasm of the cell. At low concentration, showns a homogeneous distribution throughout the cytoplasm and does not condense in speckles. During oxidative and osmotic stress, localizes to stress granules. {ECO:0000250|UniProtKB:O43781}.
uniprot
proteins