NCKIPSD
entrez
51517
canonical
uniprot
Q9NZQ3
canonical
ensembl
ENSG00000213672
resolver
ensp
ENSP00000294129
resolver
ensp
ENSP00000389059
resolver
genesymbol
NCKIPSD
resolver
genesymbol_syn
AF3P21
resolver
genesymbol_syn
SPIN90
resolver
hgnc
HGNC:15486
resolver
uniprot
B4DFL5
resolver
uniprot
Q6GU34
resolver
uniprot
Q6SPF3
resolver
uniprot
Q8TC10
resolver
uniprot
Q9UGM8
resolver
uniprot_entry
SPN90_HUMAN
resolver
uniprot_sec
B4DFL5
resolver
uniprot_sec
Q6GU34
resolver
uniprot_sec
Q6SPF3
resolver
uniprot_sec
Q8TC10
resolver
uniprot_sec
Q9UGM8
resolver
amino_acid_sequence
MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSSQIPPQPRRAAPTTPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEPGSSCSPTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSLGTTEEKAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSLVEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHILTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLNIVEDGLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLNRGDDPVRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDKLRMEYLSLMHAIVRTTPYLQHRHRLPDLQAILRRILNEEETSPQCQMDRMIVREMCKEFLVLGEAPS
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving NCKIPSD/AF3p21 is found in therapy-related leukemia. Translocation t(3;11)(p21;q23) with KMT2A/MLL1. {ECO:0000269|PubMed:10648423}.
uniprot
proteins
function
FUNCTION: Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}.
uniprot
proteins
mass_dalton
78960
uniprot
proteins
pubmed
10619843
uniprot
proteins
pubmed
10648423
uniprot
proteins
pubmed
11241789
uniprot
proteins
pubmed
11278500
uniprot
proteins
pubmed
11509578
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15095401
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
19807924
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22419821
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
722
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.
uniprot
proteins