KCNG3
entrez
170850
canonical
uniprot
Q8TAE7
canonical
ensembl
ENSG00000171126
resolver
ensp
ENSP00000304127
resolver
ensp
ENSP00000378424
resolver
genesymbol
KCNG3
resolver
hgnc
HGNC:18306
resolver
uniprot
Q53SC1
resolver
uniprot_entry
KCNG3_HUMAN
resolver
uniprot_sec
Q53SC1
resolver
amino_acid_sequence
MTFGRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELKFRSARYSRSLSTEFLN
uniprot
proteins
function
FUNCTION: Regulatory subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1, modulates the kinetics parameters of the heterotetrameric channel namely the inactivation and deactivation rate (PubMed:11852086, PubMed:12060745, PubMed:19074135). Potassium channel subunit that does not form functional channels by itself (PubMed:11852086, PubMed:12060745). Reduces the deactivation rate (PubMed:11852086). Moderately accelerates activation (PubMed:12060745). {ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:19074135}.
uniprot
proteins
mass_dalton
49593
uniprot
proteins
protein_family
G (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv6.3/KCNG3 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
11852086
uniprot
proteins
pubmed
12060745
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19074135
uniprot
proteins
sequence_length
436
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:19074135}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12060745}. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane (PubMed:12060745). Colocalizes with KCNB1 at the plasma membrane (PubMed:12060745, PubMed:19074135). Retains in the endoplasmic reticulum in the absence of KCNB1 (PubMed:12060745). {ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:19074135}.
uniprot
proteins
transmembrane_region
TRANSMEM 169..190; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 221..242; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 254..274; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 285..305; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 321..342; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 388..416; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:P63142
uniprot
proteins