TESC
entrez
54997
canonical
uniprot
Q96BS2
canonical
ensembl
ENSG00000088992
resolver
ensp
ENSP00000334785
resolver
ensp
ENSP00000445689
resolver
ensp
ENSP00000544710
resolver
ensp
ENSP00000595546
resolver
genesymbol
TESC
resolver
genesymbol_syn
CHP3
resolver
hgnc
HGNC:26065
resolver
uniprot
F5H1Y5
resolver
uniprot
Q9NWT9
resolver
uniprot_entry
CHP3_HUMAN
resolver
uniprot_sec
F5H1Y5
resolver
uniprot_sec
Q9NWT9
resolver
amino_acid_sequence
MGAAHSASEEVRELEGKTGFSSDQIEQLHRRFKQLSGDQPTIRKENFNNVPDLELNPIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPIDTTMDEEQVELSRKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCMGQMEPDQVYEGITFEDFLKIWQGIDIETKMHVRFLNMETMALCH
uniprot
proteins
function
FUNCTION: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. {ECO:0000269|PubMed:17717601, ECO:0000269|PubMed:18321853, ECO:0000269|PubMed:20060826}.
uniprot
proteins
mass_dalton
24750
uniprot
proteins
protein_family
CHP subfamily
uniprot
proteins
protein_family
Calcineurin regulatory subunit family
uniprot
proteins
pubmed
11696366
uniprot
proteins
pubmed
12809501
uniprot
proteins
pubmed
14661968
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17717601
uniprot
proteins
pubmed
18321853
uniprot
proteins
pubmed
20060826
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
25807930
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30287853
uniprot
proteins
sequence_length
214
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18321853}. Cytoplasm {ECO:0000269|PubMed:18321853}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:18321853}. Cell projection, lamellipodium {ECO:0000269|PubMed:11696366}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9JKL5}. Note=Colocalizes with SLC9A1 at the plasma membrane. {ECO:0000269|PubMed:18321853}.
uniprot
proteins