P39949
uniprot
P39949
canonical
amino_acid_sequence
MPRERKERDSKDHTKMKEEGGSDLSVRSRKRKPNVPVFLQDPDEEIAKIDKTVKSQDSSQPWDDDSACVDPCSFIPTPNKEEDNELEYPKTAFQPRKIRPPRASPLPVLNWANREEVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETFYLAQDFFDRYMASQQNIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMELMMMKALKWRLSPLTIVSWLNVYVQVAYVNDTGEVLMPQYPQQVFVQIAELLDLCVLDVGCLEFPYGVLAASALYHFSSLELMQKVSGYQWCDIEKCVKWMVPFAMVIREMGSSKLKHFRGVPMEDSHNIQTHTNSLDLLDKAQAKKAILSEQNRISPPPSGVLTPPHSSKKQSSEQETE
uniprot
proteins
function
FUNCTION: Essential for the control of the cell cycle at the G1/S (start) transition.
uniprot
proteins
mass_dalton
47482
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of both Thr-396 by GSK3 and Ser-400 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7 (By similarity). {ECO:0000250|UniProtKB:P24864}.; PTM: Ubiquitinated by UHRF2; appears to occur independently of phosphorylation. {ECO:0000250|UniProtKB:P24864}.
uniprot
proteins
protein_family
Cyclin E subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
8336937
uniprot
proteins
pubmed
8673024
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P24864}.
uniprot
proteins