HS3ST5
entrez
222537
canonical
uniprot
Q8IZT8
canonical
ensembl
ENSG00000249853
resolver
ensp
ENSP00000427888
resolver
ensp
ENSP00000570119
resolver
ensp
ENSP00000570120
resolver
ensp
ENSP00000570121
resolver
ensp
ENSP00000570122
resolver
ensp
ENSP00000570123
resolver
ensp
ENSP00000590620
resolver
ensp
ENSP00000590622
resolver
ensp
ENSP00000590623
resolver
ensp
ENSP00000590624
resolver
ensp
ENSP00000590626
resolver
ensp
ENSP00000590628
resolver
ensp
ENSP00000590630
resolver
ensp
ENSP00000590632
resolver
ensp
ENSP00000617129
resolver
enst
ENST00000312719
resolver
enst
ENST00000900060
resolver
enst
ENST00000900061
resolver
enst
ENST00000900062
resolver
enst
ENST00000900063
resolver
enst
ENST00000900064
resolver
enst
ENST00000920560
resolver
enst
ENST00000920563
resolver
enst
ENST00000920564
resolver
enst
ENST00000920566
resolver
enst
ENST00000920567
resolver
enst
ENST00000920569
resolver
enst
ENST00000920571
resolver
enst
ENST00000920573
resolver
enst
ENST00000947070
resolver
genesymbol
HS3ST5
resolver
genesymbol_syn
3OST5
resolver
genesymbol_syn
HS3OST5
resolver
hgnc
HGNC:19419
resolver
uniprot
A8K1J2
resolver
uniprot
Q52LI2
resolver
uniprot
Q8N285
resolver
uniprot_entry
HS3S5_HUMAN
resolver
uniprot_sec
A8K1J2
resolver
uniprot_sec
Q52LI2
resolver
uniprot_sec
Q8N285
resolver
amino_acid_sequence
MLFKQQAWLRQKLLVLGSLAVGSLLYLVARVGSLDRLQPICPIEGRLGGARTQAEFPLRALQFKRGLLHEFRKGNASKEQVRLHDLVQQLPKAIIIGVRKGGTRALLEMLNLHPAVVKASQEIHFFDNDENYGKGIEWYRKKMPFSYPQQITIEKSPAYFITEEVPERIYKMNSSIKLLIIVREPTTRAISDYTQVLEGKERKNKTYYKFEKLAIDPNTCEVNTKYKAVRTSIYTKHLERWLKYFPIEQFHVVDGDRLITEPLPELQLVEKFLNLPPRISQYNLYFNATRGFYCLRFNIIFNKCLAGSKGRIHPEVDPSVITKLRKFFHPFNQKFYQITGRTLNWP
uniprot
proteins
ec_number
2.8.2.23
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. {ECO:0000269|PubMed:12138164}.
uniprot
proteins
mass_dalton
40408
uniprot
proteins
mutagenesis
MUTAGEN 99; /note="R->A: Reduces enzyme activity by over 99%."; /evidence="ECO:0000269|PubMed:18223645"; MUTAGEN 104; /note="R->A: Reduces enzyme activity by 93%,."; /evidence="ECO:0000269|PubMed:18223645"; MUTAGEN 155; /note="K->A: Reduces enzyme activity by over 99%."; /evidence="ECO:0000269|PubMed:18223645"; MUTAGEN 195; /note="Q->A: Reduces enzyme activity by over 99%."; /evidence="ECO:0000269|PubMed:18223645"; MUTAGEN 309; /note="K->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:18223645"; MUTAGEN 311; /note="R->A: Reduces enzyme activity by 98%."; /evidence="ECO:0000269|PubMed:18223645
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
12138164
uniprot
proteins
pubmed
12740361
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15026143
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18223645
uniprot
proteins
pubmed
21406692
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..32; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins