Hbs1l
entrez
293408
canonical
uniprot
Q6AXM7
canonical
ensembl
ENSRNOG00000014531
resolver
ensp
ENSRNOP00000086834
resolver
ensp
ENSRNOP00000086972
resolver
ensp
ENSRNOP00000095992
resolver
enst
ENSRNOT00000113225
resolver
enst
ENSRNOT00000114016
resolver
genesymbol
Hbs1l
resolver
uniprot
A0A8I6GEG8
resolver
uniprot
A0A8I6GEM5
resolver
uniprot_entry
A0A8I6GEG8_RAT
resolver
uniprot_entry
A0A8I6GEM5_RAT
resolver
uniprot_entry
HBS1L_RAT
resolver
amino_acid_sequence
MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDNPEEEYGYEDLKESSNSLLNHQLSEIDQARLYSCLDHMREVLGDAVPDDILTEAILKHKFDVQKALSVVLEQDGVQTLKEKSERAVCAGQPSKVISRSSQSESEIVPKVAKMTVSGKKQTMGFEVPGLPSEENGHNVRAPYKGPPGDDVSIASPNVPETGTPKSTAHPPSLQTSEELGCTPTPLRKSGKLRQQIDVKAGLEKRQGGKQLLNLVVIGHVDAGKSTLMGHMLYLLGNVNKRTMHKYEQESKKAGKASFAYAWVLDETGEERERGVTMDVGMTKFETTTKVVTLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMDQVNWQQERFQEITGKLGHFLKQAGFKESDVAFIPTSGLSGENLTSRSQSSDLTKWYKGLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQGSGFCVTGKIEAGYVQTGDRLLAMPPNETCTAKGITLHDEPVDWAAAGDHVSLTLVGMDIIKINVGCIFCGPKEPIKACTRFRARILIFNIEVPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTKKKPKLLTKGQNALVELQTQRPVALELYKDFKELGRFMLRYGGSTVAAGVVTEIKE
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. {ECO:0000250|UniProtKB:Q9Y450}.
uniprot
proteins
mass_dalton
74774
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
679
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y450}.
uniprot
proteins