Actrt1
entrez
73360
canonical
uniprot
Q9D9J3
canonical
ensembl
ENSMUSG00000046615
resolver
ensp
ENSMUSP00000062570
resolver
enst
ENSMUST00000059466
resolver
genesymbol
Actrt1
resolver
uniprot_entry
ACTT1_MOUSE
resolver
amino_acid_sequence
MLDPARLDNPAVIFDNGSGLCKVGISGEIEPRHVINSVVGHPKFNIPSARSNRKRYFVGEEAQCMYDGLYLHYPIERGLVTRWDDMEKLWKDLFEWELGVKPNEQPVFMTEPSLNPQETREKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVPVYEGYSLPHAITKLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVSLGYKDTEKNCQQFLRKYTLPDGNTIQMSDHLCQVPEVLFTPDHLGIHDLGISKMVCNSIMNCDTDIQENLFAEIVLSGGTTMFPGLQDRLLKELEDLAFEGTPIKITASSDRCYSAWIGGSVMTSMTTFKQMWVTAEDFKEYGAFVVQRKCF
uniprot
proteins
function
FUNCTION: Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. {ECO:0000250|UniProtKB:Q8TDG2}.
uniprot
proteins
mass_dalton
42216
uniprot
proteins
protein_family
Actin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8TDG2}. Cytoplasm {ECO:0000250|UniProtKB:Q8TDG2}. Nucleus {ECO:0000250|UniProtKB:Q8TDG2}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8TDG2}. Note=Both detected in the nucleus and cytoplasm, localizes to the nucleus where it binds chromatin upon stimulation of the Hedgehog pathway. {ECO:0000250|UniProtKB:Q8TDG2}.
uniprot
proteins