Rcvrn
entrez
19674
canonical
uniprot
P34057
canonical
ensembl
ENSMUSG00000020907
resolver
ensp
ENSMUSP00000021290
resolver
enst
ENSMUST00000021290
resolver
genesymbol
Rcvrn
resolver
genesymbol_syn
Rcv1
resolver
uniprot
Q2TB46
resolver
uniprot_entry
Q2TB46_MOUSE
resolver
uniprot_entry
RECO_MOUSE
resolver
amino_acid_sequence
MGNSKSGALSKEILEELQLNTKFTEEELSAWYQSFLKECPSGRITRQEFESIYSKFFPDSDPKAYAQHVFRSFDANSDGTLDFKEYVIALHMTTAGKPTQKLEWAFSLYDVDGNGTISKNEVLEIVMAIFKMIKPEDVKLLPDDENTPEKRAEKIWAFFGKKEDDKLTEEEFIEGTLANKEILRLIQFEPQKVKERIKEKKQ
uniprot
proteins
function
FUNCTION: Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (PubMed:25673692). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (PubMed:15882641). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (PubMed:29435986). {ECO:0000250|UniProtKB:P21457, ECO:0000269|PubMed:15882641, ECO:0000269|PubMed:25673692, ECO:0000269|PubMed:29435986}.
uniprot
proteins
mass_dalton
23407
uniprot
proteins
post_translational_modification
PTM: The N-terminal glycine is linked to one of four different types of acyl groups. The most abundant is myristoleate (14:1), but 14:0, 14:2, and 12:0 acyl residues are also present (By similarity). The Ca(2+) induced exposure of the myristoyl group, known as the calcium-myristoyl switch, promotes RCVRN binding to the photoreceptor cell membranes only when intracellular Ca(2+) concentration is high (By similarity). {ECO:0000250|UniProtKB:P21457}.; PTM: Oxidation on Cys-39 occurs in response to prolonged intense illumination and results in the formation of disulfide homodimers, and to a lesser extent disulfide-linked heterodimers. {ECO:0000250|UniProtKB:P21457}.
uniprot
proteins
protein_family
Recoverin family
uniprot
proteins
pubmed
1386025
uniprot
proteins
pubmed
15882641
uniprot
proteins
pubmed
15961391
uniprot
proteins
pubmed
25673692
uniprot
proteins
pubmed
28151698
uniprot
proteins
pubmed
29435986
uniprot
proteins
sequence_length
202
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor inner segment {ECO:0000269|PubMed:15882641, ECO:0000269|PubMed:15961391, ECO:0000269|PubMed:28151698}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:15882641, ECO:0000269|PubMed:15961391, ECO:0000269|PubMed:28151698}. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P21457}; Lipid-anchor {ECO:0000250|UniProtKB:P21457}; Cytoplasmic side {ECO:0000250|UniProtKB:P21457}. Perikaryon {ECO:0000269|PubMed:28151698}. Note=Primarily expressed in the inner segments of light-adapted rod photoreceptors, approximately 10% of which translocates from photoreceptor outer segments upon light stimulation (PubMed:15961391). Targeting of myristoylated protein to rod photoreceptor outer segments is calcium dependent (By similarity). {ECO:0000250|UniProtKB:P21457, ECO:0000269|PubMed:15961391}.
uniprot
proteins