Cd160
entrez
54215
canonical
uniprot
O88875
canonical
ensembl
ENSMUSG00000038304
resolver
ensp
ENSMUSP00000037466
resolver
ensp
ENSMUSP00000102689
resolver
ensp
ENSMUSP00000132363
resolver
enst
ENSMUST00000047702
resolver
enst
ENSMUST00000107074
resolver
enst
ENSMUST00000165991
resolver
genesymbol
Cd160
resolver
genesymbol_syn
By55
resolver
uniprot
E9Q0X3
resolver
uniprot
Q8C9H4
resolver
uniprot_entry
BY55_MOUSE
resolver
uniprot_entry
E9Q0X3_MOUSE
resolver
uniprot_sec
Q8C9H4
resolver
amino_acid_sequence
MQRILMAPGQSCCALAILLAIVNFQHGGCIHVTSSASQKGGRLDLTCTLWHKKDEAEGLILFWCKDNPWNCSPETNLEQLRVKRDPETDGITEKSSQLVFTIEQATPSDSGTYQCCARSQKPEIYIHGHFLSVLVTGNHTEIRQRQRSHPDFSHINGTLSSGFLQVKAWGMLVTSLVALQALYTL
uniprot
proteins
function
FUNCTION: [CD160 antigen]: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (By similarity). Receptor for both classical and non-classical MHC class I molecules (PubMed:16177084). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (PubMed:25711213). On activated CD4+ T cells, interacts with TNFRSF14 and down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (By similarity). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (PubMed:22801499). {ECO:0000250|UniProtKB:O95971, ECO:0000269|PubMed:16177084, ECO:0000269|PubMed:22801499, ECO:0000269|PubMed:25711213}.; FUNCTION: [CD160 antigen, soluble form]: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions. {ECO:0000250|UniProtKB:O95971}.
uniprot
proteins
mass_dalton
20570
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16177084
uniprot
proteins
pubmed
18193050
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22801499
uniprot
proteins
pubmed
25711213
uniprot
proteins
pubmed
9743336
uniprot
proteins
sequence_length
185
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [CD160 antigen]: Cell membrane {ECO:0000269|PubMed:22801499, ECO:0000269|PubMed:25711213}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:O95971}.; SUBCELLULAR LOCATION: [CD160 antigen, soluble form]: Secreted {ECO:0000250|UniProtKB:O95971, ECO:0000305|PubMed:16177084}. Note=Released from the cell membrane by GPI cleavage. {ECO:0000250|UniProtKB:O95971, ECO:0000305|PubMed:16177084}.
uniprot
proteins