Kyat1
entrez
311844
canonical
uniprot
Q08415
canonical
ensembl
ENSRNOG00000016097
resolver
ensp
ENSRNOP00000021865
resolver
ensp
ENSRNOP00000085700
resolver
ensp
ENSRNOP00000091831
resolver
enst
ENSRNOT00000095192
resolver
enst
ENSRNOT00000102626
resolver
genesymbol
Kyat1
resolver
genesymbol_syn
Ccbl1
resolver
genesymbol_syn
Kat
resolver
uniprot
A0A8I5ZZT5
resolver
uniprot
A0A8I6AEE2
resolver
uniprot
Q9R096
resolver
uniprot_entry
A0A8I5ZZT5_RAT
resolver
uniprot_entry
A0A8I6AEE2_RAT
resolver
uniprot_entry
KAT1_RAT
resolver
uniprot_sec
Q9R096
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by aminooxyacetate (in vitro). {ECO:0000269|PubMed:2072101}.
uniprot
proteins
amino_acid_sequence
MTKRLQARRLDGIDQNLWVEFGKLTKEYDVVNLGQGFPDFSPPDFATQAFQQATSGNFMLNQYTRAFGYPPLTNVLASFFGKLLGQEMDPLTNVLVTVGAYGALFTRFQALVDEGDEVIIMEPAFDCYEPMTMMAGGCPVFVTLKPSPAPKGKLGASNDWQLDPAELASKFTPRTKILVLNTPNNPLGKVFSRMELELVANLCQQHDVVCISDEVYQWLVYDGHQHVSIASLPGMWDRTLTIGSAGKSFSATGWKVGWVMGPDNIMKHLRTVHQNSIFHCPTQAQAAVAQCFEREQQHFGQPSSYFLQLPQAMELNRDHMIRSLQSVGLKLWISQGSYFLIADISDFKSKMPDLPGAEDEPYDRRFAKWMIKNMGLVGIPVSTFFSRPHQKDFDHYIRFCFVKDKATLQAMDERLRKWKELQP
uniprot
proteins
ec_number
2.6.1.64
uniprot
proteins
ec_number
2.6.1.7
uniprot
proteins
ec_number
4.4.1.13
uniprot
proteins
function
FUNCTION: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:2072101, PubMed:6783036, PubMed:7796908). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:8502223). {ECO:0000269|PubMed:2072101, ECO:0000269|PubMed:6783036, ECO:0000269|PubMed:7796908, ECO:0000269|PubMed:8502223}.
uniprot
proteins
mass_dalton
47873
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2. {ECO:0000305|PubMed:7796908}.
uniprot
proteins
protein_family
Class-I pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
12850267
uniprot
proteins
pubmed
2072101
uniprot
proteins
pubmed
6783036
uniprot
proteins
pubmed
7796908
uniprot
proteins
pubmed
7926014
uniprot
proteins
pubmed
8502223
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:7796908, ECO:0000269|PubMed:8502223}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion matrix {ECO:0000269|PubMed:7796908}.
uniprot
proteins