MISP
entrez
126353
canonical
uniprot
Q8IVT2
canonical
ensembl
ENSG00000099812
resolver
ensp
ENSP00000215582
resolver
ensp
ENSP00000541324
resolver
ensp
ENSP00000541326
resolver
ensp
ENSP00000541327
resolver
ensp
ENSP00000541329
resolver
ensp
ENSP00000541330
resolver
ensp
ENSP00000541331
resolver
ensp
ENSP00000541332
resolver
ensp
ENSP00000541333
resolver
ensp
ENSP00000541334
resolver
ensp
ENSP00000541335
resolver
ensp
ENSP00000541337
resolver
ensp
ENSP00000541338
resolver
ensp
ENSP00000541339
resolver
ensp
ENSP00000541340
resolver
ensp
ENSP00000541341
resolver
ensp
ENSP00000541342
resolver
ensp
ENSP00000541343
resolver
enst
ENST00000215582
resolver
enst
ENST00000871265
resolver
enst
ENST00000871267
resolver
enst
ENST00000871268
resolver
enst
ENST00000871270
resolver
enst
ENST00000871271
resolver
enst
ENST00000871272
resolver
enst
ENST00000871273
resolver
enst
ENST00000871274
resolver
enst
ENST00000871275
resolver
enst
ENST00000871276
resolver
enst
ENST00000871278
resolver
enst
ENST00000871279
resolver
enst
ENST00000871280
resolver
enst
ENST00000871281
resolver
enst
ENST00000871282
resolver
enst
ENST00000871283
resolver
enst
ENST00000871284
resolver
genesymbol
MISP
resolver
genesymbol_syn
C19orf21
resolver
hgnc
HGNC:27000
resolver
uniprot_entry
MISP_HUMAN
resolver
amino_acid_sequence
MDRVTRYPILGIPQAHRGTGLVLDGDTSYTYHLVCMGPEASGWGQDEPQTWPTDHRAQQGVQRQGVSYSVHAYTGQPSPRGLHSENREDEGWQVYRLGARDAHQGRPTWALRPEDGEDKEMKTYRLDAGDADPRRLCDLERERWAVIQGQAVRKSSTVATLQGTPDHGDPRTPGPPRSTPLEENVVDREQIDFLAARQQFLSLEQANKGAPHSSPARGTPAGTTPGASQAPKAFNKPHLANGHVVPIKPQVKGVVREENKVRAVPTWASVQVVDDPGSLASVESPGTPKETPIEREIRLAQEREADLREQRGLRQATDHQELVEIPTRPLLTKLSLITAPRRERGRPSLYVQRDIVQETQREEDHRREGLHVGRASTPDWVSEGPQPGLRRALSSDSILSPAPDARAADPAPEVRKVNRIPPDAYQPYLSPGTPQLEFSAFGAFGKPSSLSTAEAKAATSPKATMSPRHLSESSGKPLSTKQEASKPPRGCPQANRGVVRWEYFRLRPLRFRAPDEPQQAQVPHVWGWEVAGAPALRLQKSQSSDLLERERESVLRREQEVAEERRNALFPEVFSPTPDENSDQNSRSSSQASGITGSYSVSESPFFSPIHLHSNVAWTVEDPVDSAPPGQRKKEQWYAGINPSDGINSEVLEAIRVTRHKNAMAERWESRIYASEEDD
uniprot
proteins
function
FUNCTION: Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}.
uniprot
proteins
mass_dalton
75357
uniprot
proteins
mutagenesis
MUTAGEN 78; /note="S->A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-164; A-172; A-214; A-224; A-284; A-287; A-377 and A-575."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 164; /note="T->A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-78; A-172; A-214; A-224; A-284; A-287; A-377 and A-575."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 172; /note="T->A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-78; A-164; A-214; A-224; A-284; A-287; A-377 and A-575."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 214; /note="S->A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-78; A-164; A-172; A-224; A-284; A-287; A-377 and A-575."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 224; /note="T->A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-78; A-164; A-172; A-214; A-284; A-287; A-377 and A-575."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 284; /note="S->A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-78; A-164; A-172; A-214; A-224; A-287; A-377 and A-575."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 287; /note="T->A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-78; A-164; A-172; A-214; A-224; A-284; A-377 and A-575."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 377; /note="T->A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-78; A-164; A-172; A-214; A-224; A-284; A-287 and A-575."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 382; /note="S->A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-394; A-395; A-397; A-471; A-582 and A-586."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 394; /note="S->A: Drastic reduction in PLK1 phosphorylation in vitro, no effect on cortical localization; when associated with A-382; A-395; A-397; A-471; A-582 and A-586."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 394; /note="S->D: No effect on cortical localization; when associated with D-395; D-397; D-471; D-582 and D-586."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 395; /note="S->A: Drastic reduction in PLK1 phosphorylation in vitro, no effect on cortical localization; when associated with A-382; A-394; A-397; A-471; A-582 and A-586."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 395; /note="S->D: No effect on cortical localization; when associated with D-394; D-397; D-471; D-582 and D-586."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 397; /note="S->A: Drastic reduction in PLK1 phosphorylation in vitro, no effect on cortical localization; when associated with A-382; A-394; A-395; A-471; A-582 and A-586."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 397; /note="S->D: No effect on cortical localization; when associated with D-394; D-395; D-471; D-582 and D-586."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 471; /note="S->A: Drastic reduction in PLK1 phosphorylation in vitro, no effect on cortical localization; when associated with A-382; A-394; A-395; A-397; A-582 and A-586."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 471; /note="S->D: No effect on cortical localization; when associated with D-394; D-395; D-397; D-582 and D-586."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 575; /note="S->A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-78; A-164; A-172; A-214; A-224; A-284; A-287 and A-377."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 582; /note="S->A: Drastic reduction in PLK1 phosphorylation in vitro, no effect on cortical localization; when associated with A-382; A-394; A-395; A-397; A-471 and A-586."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 582; /note="S->D: No effect on cortical localization; when associated with D-394; D-395; D-397; D-471 and D-586."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 586; /note="S->A: Drastic reduction in PLK1 phosphorylation in vitro, no effect on cortical localization; when associated with A-382; A-394; A-395; A-397; A-471 and A-582."; /evidence="ECO:0000269|PubMed:23509069"; MUTAGEN 586; /note="S->D: No effect on cortical localization; when associated with D-394; D-395; D-397; D-471 and D-582."; /evidence="ECO:0000269|PubMed:23509069
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK1 and PLK1. CDK1 is the priming kinase for PLK1 phosphorylation. Phosphorylation by PLK1 is required for proper spindle orientation at metaphase. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}.
uniprot
proteins
protein_family
MISP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23509069
uniprot
proteins
pubmed
23574715
uniprot
proteins
sequence_length
679
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re-attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis.
uniprot
proteins