RPS6KA6
entrez
27330
canonical
uniprot
Q9UK32
canonical
ensembl
ENSG00000072133
resolver
ensp
ENSP00000262752
resolver
ensp
ENSP00000483896
resolver
genesymbol
RPS6KA6
resolver
genesymbol_syn
RSK4
resolver
hgnc
HGNC:10435
resolver
uniprot
A0AAU7BMN7
resolver
uniprot
A0AAU7BMR9
resolver
uniprot
A0AAU7BMT2
resolver
uniprot
A0AAU7BN28
resolver
uniprot
B2R854
resolver
uniprot
B7ZL90
resolver
uniprot
Q6FHX2
resolver
uniprot
Q8WX28
resolver
uniprot
Q9H4S6
resolver
uniprot_entry
A0AAU7BMN7_HUMAN
resolver
uniprot_entry
A0AAU7BMR9_HUMAN
resolver
uniprot_entry
A0AAU7BMT2_HUMAN
resolver
uniprot_entry
A0AAU7BN28_HUMAN
resolver
uniprot_entry
KS6A6_HUMAN
resolver
uniprot_sec
B2R854
resolver
uniprot_sec
B7ZL90
resolver
uniprot_sec
Q6FHX2
resolver
uniprot_sec
Q8WX28
resolver
uniprot_sec
Q9H4S6
resolver
activity_regulation
ACTIVITY REGULATION: Constitutively activated by phosphorylation at Ser-232, Ser-372, and Ser-389 in serum-starved cells. Does not require growth factor stimulation for significant kinase activity. {ECO:0000269|PubMed:15632195}.
uniprot
proteins
amino_acid_sequence
MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}.
uniprot
proteins
mass_dalton
83872
uniprot
proteins
mutagenesis
MUTAGEN 372; /note="S->A: No effect on activity."; /evidence="ECO:0000269|PubMed:15632195"; MUTAGEN 389; /note="S->A: Strongly decreases activity."; /evidence="ECO:0000269|PubMed:15632195"; MUTAGEN 581; /note="T->A: No effect on activity."; /evidence="ECO:0000269|PubMed:15632195
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-232, Ser-372, and Ser-389 in serum-starved cells. {ECO:0000269|PubMed:15632195}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
S6 kinase subfamily
uniprot
proteins
pubmed
10644430
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15042092
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15632195
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18813292
uniprot
proteins
pubmed
21406692
uniprot
proteins
sequence_length
745
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15632195}. Nucleus {ECO:0000269|PubMed:15632195}. Note=Predominantly cytosolic.
uniprot
proteins