Gdpd5
entrez
233552
canonical
uniprot
Q640M6
canonical
ensembl
ENSMUSG00000035314
resolver
ensp
ENSMUSP00000036175
resolver
ensp
ENSMUSP00000150361
resolver
ensp
ENSMUSP00000269962
resolver
ensp
ENSMUSP00000269963
resolver
ensp
ENSMUSP00000269965
resolver
ensp
ENSMUSP00000269974
resolver
enst
ENSMUST00000037528
resolver
enst
ENSMUST00000213887
resolver
genesymbol
Gdpd5
resolver
genesymbol_syn
Gde2
resolver
uniprot
A0A1L1STK0
resolver
uniprot
Q8R0T5
resolver
uniprot
Q8R3N5
resolver
uniprot_entry
A0A1L1STK0_MOUSE
resolver
uniprot_entry
GDE2_MOUSE
resolver
uniprot_sec
Q8R0T5
resolver
uniprot_sec
Q8R3N5
resolver
activity_regulation
ACTIVITY REGULATION: Activated by PRDX1 through reduction of an intramolecular disulfide bond (By similarity). Inhibited by high level of NaCl or urea. {ECO:0000250|UniProtKB:Q3KTM2, ECO:0000269|PubMed:18667693}.
uniprot
proteins
amino_acid_sequence
MVRHQPLQYYEPQLCLSCLTGIYGCRWKRYQRSHDDTTPWERLWFLLLVCTFSLTLTWLYFWWGVHNDYDEFNWYLYNRMGYWSDWSVPILVTSAAAFTYIAGLLVLALCHIAVGQQLNLHWIHKMGLVVILASTVVAMSAVAQLWEDEWEVLLISLQGTAPFLHIGALVAITALSWIVAGQFARAERSSSQLTILCTFFAVVFTFYLIPLTISSPCIMEKKDLGPKPALIGHRGAPMLAPEHTVMSFRKALEQRLYGLQADITISLDGVPFLMHDTTLRRTTNVEHLFPELARRPAAMLNWTVLQRLNAGQWFLKTDPFWTASSLSPSDHREVQNQSICSLAELLELAKGNASLLLNLRDPPRDHPYRGSFLNVTLEAVLRSGFPQHQVMWLFNRQRPLVRKMAPGFQQTSGSKEAIANLRKGHIQKLNLRYTQVSHQELRDYASWNLSVNLYTVNAPWLFSLLWCAGVPSVTSDNSHTLSRVPSPLWIMPPDEYCLMWVTADLISFSLIIGIFVLQKWRLGGIRSYNPEQIMLSAAVRRTSRDVSIMKEKLIFSEISDGVEVSDELSVCSDSSYDTYANANSTATPVGPRNAGSRAKTVTEQSGH
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
ec_number
3.1.4.2
uniprot
proteins
function
FUNCTION: Ecto-phospholipase that cleaves the phosphodiester bond in the glycosylphosphatidylinositol (GPI) anchor of various proteins, releasing them from the plasma membrane into the extracellular space. Cleaves the GPI-anchor of glypican-6/GPC6, thereby positively regulating neuron differentiation in a cell-autonomous manner. May also hydrolyze the GPI-anchor of glypican-3/GPC3. Cleaves the GPI-anchor of the serine protease inhibitor RECK, leading to its inactivation (PubMed:33731436). RECK inactivation inhibits NOTCH signaling in neighboring cells and induces differentiation of spinal motor neurons (Probable). RECK inactivation can also regulate amyloid-beta precursor protein (APP) processing by ADAM10 (PubMed:33731436). May additionally catalyze the hydrolysis of the phosphodiester bond in sn-glycerol 3-phosphocholine, potentially contributing to osmotic regulation of cellular glycerophosphocholine levels (PubMed:18667693). {ECO:0000269|PubMed:18667693, ECO:0000269|PubMed:33731436, ECO:0000305|PubMed:17275818}.
uniprot
proteins
mass_dalton
68890
uniprot
proteins
post_translational_modification
PTM: The reduction by PRDX1 of an intramolecular disulfide bond between Cys-25 and Cys-571 could activate the phosphodiesterase activity. {ECO:0000250|UniProtKB:Q3KTM2}.
uniprot
proteins
protein_family
Glycerophosphoryl diester phosphodiesterase family
uniprot
proteins
pubmed
15276213
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17275818
uniprot
proteins
pubmed
18667693
uniprot
proteins
pubmed
33731436
uniprot
proteins
sequence_length
607
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:33731436}; Multi-pass membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:33731436}; Multi-pass membrane protein {ECO:0000255}. Cell projection, growth cone {ECO:0000269|PubMed:17275818}. Note=Colocalizes with recycling endosome as it undergoes constitutive clathrin- and dynamin-mediated internalization and recycling. {ECO:0000269|PubMed:15276213, ECO:0000269|PubMed:17275818, ECO:0000269|PubMed:18667693}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..63; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 126..146; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 497..517; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins