Aqp5
entrez
11830
canonical
uniprot
Q9WTY4
canonical
ensembl
ENSMUSG00000044217
resolver
ensp
ENSMUSP00000127611
resolver
enst
ENSMUST00000169082
resolver
genesymbol
Aqp5
resolver
uniprot
Q545H1
resolver
uniprot_entry
AQP5_MOUSE
resolver
uniprot_sec
Q545H1
resolver
amino_acid_sequence
MKKEVCSVAFFKAVFAEFLATLIFVFFGLGSALKWPSALPTILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISLLRAIFYVAAQLVGAIAGAGILYWLAPGNARGNLAVNALSNNTTPGKAVVVELILTFQLALCIFSSTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPSHWVFWVGPIVGAVLAAILYFYLLFPSSLSLHDRVAVVKGTYEPEEDWEDHREERKKTIELTAH
uniprot
proteins
function
FUNCTION: Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (By similarity). Plays an important role in fluid secretion in salivary glands (PubMed:10400615, PubMed:16571723, PubMed:18027168). Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Seems to play a redundant role in water transport in the eye, lung and in sweat glands (PubMed:10619865, PubMed:12042359, PubMed:18027168). {ECO:0000250|UniProtKB:P55064, ECO:0000269|PubMed:10400615, ECO:0000269|PubMed:10619865, ECO:0000269|PubMed:12042359, ECO:0000269|PubMed:16571723, ECO:0000269|PubMed:18027168}.
uniprot
proteins
mass_dalton
28274
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
10337625
uniprot
proteins
pubmed
10400615
uniprot
proteins
pubmed
10619865
uniprot
proteins
pubmed
12042359
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16571723
uniprot
proteins
pubmed
18027168
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23473857
uniprot
proteins
sequence_length
265
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:10400615, ECO:0000269|PubMed:12042359, ECO:0000269|PubMed:16571723, ECO:0000269|PubMed:18027168, ECO:0000269|PubMed:23473857}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55064}. Cell membrane {ECO:0000250|UniProtKB:P55064}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55064}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:23473857}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55064}. Note=Hypotonicity increases location at the cell membrane. Phosphorylation decreases location at the cell membrane. {ECO:0000250|UniProtKB:P55064}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55064"; TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55064"; TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55064"; TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55064"; TRANSMEM 159..179; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55064"; TRANSMEM 204..224; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55064
uniprot
proteins