Pla2g2a
entrez
18780
canonical
uniprot
P31482
canonical
ensembl
ENSMUSG00000058908
resolver
genesymbol
Pla2g2a
resolver
uniprot
Q60871
resolver
uniprot
V5TDK8
resolver
uniprot_entry
PA2GA_MOUSE
resolver
uniprot_entry
V5TDK8_MOUSE
resolver
uniprot_sec
Q60871
resolver
amino_acid_sequence
MKVLLLLAASIMAFGSIQVQGNIAQFGEMIRLKTGKRAELSYAFYGCHCGLGGKGSPKDATDRCCVTHDCCYKSLEKSGCGTKLLKYKYSHQGGQITCSANQNSCQKRLCQCDKAAAECFARNKKTYSLKYQFYPNMFCKGKKPKC
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration (PubMed:10358193, PubMed:11694541, PubMed:8425615). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes. Simultaneously, by compromising mitochondrial membrane integrity, promotes the release in circulation of potent damage-associated molecular pattern molecules that activate the innate immune response (By similarity). Plays a stem cell regulator role in the intestinal crypt. Within intracellular compartment mediates Paneth cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ICS). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ICS cells and tissue regeneration (PubMed:27292189). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner (By similarity). {ECO:0000250|UniProtKB:P14555, ECO:0000269|PubMed:10358193, ECO:0000269|PubMed:11694541, ECO:0000269|PubMed:27292189, ECO:0000269|PubMed:8425615}.
uniprot
proteins
mass_dalton
16145
uniprot
proteins
protein_family
Phospholipase A2 family
uniprot
proteins
pubmed
10358193
uniprot
proteins
pubmed
11694541
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
27292189
uniprot
proteins
pubmed
7673223
uniprot
proteins
pubmed
7781071
uniprot
proteins
pubmed
8250944
uniprot
proteins
pubmed
8267767
uniprot
proteins
pubmed
8425615
uniprot
proteins
sequence_length
146
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P14555}. Cell membrane {ECO:0000250|UniProtKB:P14555}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14555}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P14555}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14555}.
uniprot
proteins