Dpep1
entrez
13479
canonical
uniprot
P31428
canonical
ensembl
ENSMUSG00000019278
resolver
ensp
ENSMUSP00000019422
resolver
ensp
ENSMUSP00000272599
resolver
enst
ENSMUST00000019422
resolver
genesymbol
Dpep1
resolver
genesymbol_syn
Mbd1
resolver
genesymbol_syn
Rdp
resolver
uniprot
G5E824
resolver
uniprot
Q3V175
resolver
uniprot_entry
DPEP1_MOUSE
resolver
uniprot_entry
Q3V175_MOUSE
resolver
uniprot_sec
G5E824
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by L-penicillamine. Inhibited by cilastatin. {ECO:0000250|UniProtKB:P16444}.
uniprot
proteins
amino_acid_sequence
MVIIWWFWSLLAICASDSFRDQAVAIMRTTPVIDGHNDLPWQLLNLFNNQLLRPDADLNKLAQTHTNIPKLKAGFVGGQFWSAYMPCDTQNKDAVKRILEQMDVIHRMCQLYPETFMCVTNSSDILQAFRRGKVASLIGVEGGHLIDSSLGVLRTLYHLGMRYLTLTHNCNTPWADNWLVDRGDDEAESHGLSPFGKRLLNEMNRLGVMIDLSHVSVATMKDALQISRAPVIFSHSSAYSLCPHRRNVPDDVLQLVKNTSSLVMVNFFSNFVSCSDSATLPQVADHLDHIKKVAGAGAVGLGGDYDGVTMLPVGLEDVSKYPDLIAELLRRNWTETEVRGLLADNLIRVFSEVELVSNNMQSPEEVPITLKELDGSCRTYYGYSQAHSIHLQTGALVASLASLLFRLHLL
uniprot
proteins
ec_number
3.4.13.19
uniprot
proteins
ec_number
3.5.2.6
uniprot
proteins
function
FUNCTION: Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:12738806, PubMed:31442408, PubMed:9560193). Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (PubMed:12738806, PubMed:9560193). Also possesses beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics (PubMed:12738806). {ECO:0000269|PubMed:12738806, ECO:0000269|PubMed:31442408, ECO:0000269|PubMed:9560193}.; FUNCTION: Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver. {ECO:0000269|PubMed:31442408}.
uniprot
proteins
mass_dalton
45722
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
protein_family
Peptidase M19 family
uniprot
proteins
pubmed
12738806
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31442408
uniprot
proteins
pubmed
8507661
uniprot
proteins
pubmed
9560193
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P16444}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P16444}. Cell projection, microvillus membrane {ECO:0000250|UniProtKB:P16444}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P16444}. Note=Brush border membrane. {ECO:0000250|UniProtKB:P31429}.
uniprot
proteins