Aqp1
entrez
25240
canonical
uniprot
P29975
canonical
ensembl
ENSRNOG00000011648
resolver
ensembl
ENSRNOG00055010900
resolver
ensembl
ENSRNOG00060022640
resolver
ensembl
ENSRNOG00065011980
resolver
ensp
ENSRNOP00000015692
resolver
ensp
ENSRNOP00055014849
resolver
ensp
ENSRNOP00060032491
resolver
ensp
ENSRNOP00065014908
resolver
enst
ENSRNOT00000015692
resolver
enst
ENSRNOT00055018453
resolver
enst
ENSRNOT00060039288
resolver
enst
ENSRNOT00065019471
resolver
genesymbol
Aqp1
resolver
genesymbol_syn
Chip28
resolver
uniprot
Q5EB50
resolver
uniprot
Q7TN36
resolver
uniprot_entry
AQP1_RAT
resolver
uniprot_sec
Q5EB50
resolver
uniprot_sec
Q7TN36
resolver
amino_acid_sequence
MASEIKKKLFWRAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAVMYIIAQCVGAIVASAILSGITSSLLENSLGRNDLARGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGSALAVLIYDFILAPRSSDFTDRMKVWTSGQVEEYDLDADDINSRVEMKPK
uniprot
proteins
function
FUNCTION: Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues. Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol. In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo. {ECO:0000250|UniProtKB:P29972}.
uniprot
proteins
mass_dalton
28857
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
1280133
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16133142
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7530838
uniprot
proteins
pubmed
8421053
uniprot
proteins
pubmed
8508530
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16133142}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P29972}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..29; /note="Helical; Name=Helix 1"; /evidence="ECO:0000250|UniProtKB:P29972"; TRANSMEM 47..65; /note="Helical; Name=Helix 2"; /evidence="ECO:0000250|UniProtKB:P29972"; TRANSMEM 91..109; /note="Helical; Name=Helix 3"; /evidence="ECO:0000250|UniProtKB:P29972"; TRANSMEM 134..153; /note="Helical; Name=Helix 4"; /evidence="ECO:0000250|UniProtKB:P29972"; TRANSMEM 164..181; /note="Helical; Name=Helix 5"; /evidence="ECO:0000250|UniProtKB:P29972"; TRANSMEM 207..224; /note="Helical; Name=Helix 6"; /evidence="ECO:0000250|UniProtKB:P29972
uniprot
proteins