Pklr
entrez
24651
canonical
uniprot
P12928
canonical
ensembl
ENSRNOG00000020420
resolver
ensembl
ENSRNOG00065024916
resolver
ensp
ENSRNOP00000027700
resolver
ensp
ENSRNOP00000093132
resolver
genesymbol
Pklr
resolver
uniprot
B1WBN9
resolver
uniprot
P04763
resolver
uniprot
Q64618
resolver
uniprot_entry
B1WBN9_RAT
resolver
uniprot_entry
KPYR_RAT
resolver
uniprot_sec
P04763
resolver
uniprot_sec
Q64618
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by fructose 1,6-bisphosphate. {ECO:0000250|UniProtKB:P30613}.
uniprot
proteins
amino_acid_sequence
MSVQENTLPQQLWPWIFRSQKDLAKSALSGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSQPVAARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSPLSYRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSVS
uniprot
proteins
ec_number
2.7.1.40
uniprot
proteins
function
FUNCTION: Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis. Also produces the side product 2-phospholactate which can inhibit fructose-2,6-bisphosphate production. 2-phospholactate can be dephosphorylated by PGP which prevents the inhibition of fructose-2,6-bisphosphate production and allows glycolysis to occur. {ECO:0000250|UniProtKB:P30613}.
uniprot
proteins
mass_dalton
62200
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. {ECO:0000250|UniProtKB:P30613}.
uniprot
proteins
protein_family
Pyruvate kinase family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
3002799
uniprot
proteins
pubmed
3080337
uniprot
proteins
pubmed
3309348
uniprot
proteins
pubmed
3654663
uniprot
proteins
sequence_length
574
uniprot
proteins