Pltp
entrez
18830
canonical
uniprot
P55065
canonical
ensembl
ENSMUSG00000017754
resolver
ensp
ENSMUSP00000061519
resolver
ensp
ENSMUSP00000104939
resolver
enst
ENSMUST00000059954
resolver
enst
ENSMUST00000109316
resolver
genesymbol
Pltp
resolver
uniprot
Q3UE59
resolver
uniprot
Q3UFS5
resolver
uniprot
Q99L70
resolver
uniprot_entry
PLTP_MOUSE
resolver
uniprot_entry
Q3UE59_MOUSE
resolver
uniprot_entry
Q3UFS5_MOUSE
resolver
uniprot_sec
Q99L70
resolver
amino_acid_sequence
MVLLWALFLALLAGAHAELPGCKIRVTSAALDLVKQEGLRFLEQELETITIPDVYGAKGHFYYNISDVRVTQLHLISSELHFQPDQDLLLNISNASLGLHFRRQLLYWFLYDGGYINASAEGVSIRTGLQLSQDSSGRIKVSNVSCEASVSKMNMAFGGTFRRMYNFFSTFITSGMRFLLNQQICPVLYHAGTVLLNSLLDTVPVRSSVDDLVGIDYSLLKDPVVSNGNLDMEFRGAFFPLKEDNWSLPNRAVEPQLEDDERMVYVAFSEFFFDSAMESYFQAGALQLTLVGDKVPSDLDMLLRATYFGSIVLLSPTVINSPLKLKLEATSPPRCTIKPSGTTISITASVTITLAPPMLPEVELSKMIMEGRLSAKLTLRGKALRVKLDLRRFQIYSNQSALESLALIPLQAPLKTLLQIGVMPLLNERTWRGVQIPLPEGINFVREVVTNHAGFVTVGADLHFAKGLREVIDKNRPADVAASHVPPPSAAAA
uniprot
proteins
function
FUNCTION: Mediates the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low density lipoproteins or LDL and very low density lipoproteins or VLDL) into high-density lipoproteins (HDL) as well as the exchange of phospholipids between triglyceride-rich lipoproteins themselves (PubMed:10079112, PubMed:7615508, PubMed:7654777). Facilitates the transfer of a spectrum of different lipid molecules, including sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, and phosphatidyl ethanolamine (PubMed:10079112). Plays an important role in HDL remodeling which involves modulating the size and composition of HDL (By similarity). Also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion (By similarity). Two distinct forms of PLTP exist in plasma: an active form that can transfer phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form that lacks this capability (By similarity). {ECO:0000250|UniProtKB:P55058, ECO:0000269|PubMed:10079112, ECO:0000269|PubMed:7615508, ECO:0000269|PubMed:7654777}.
uniprot
proteins
mass_dalton
54453
uniprot
proteins
post_translational_modification
PTM: Glycosylation is necessary for secretion and its phospholipid transfer activity. {ECO:0000250|UniProtKB:P55058}.
uniprot
proteins
protein_family
BPI/LBP family
uniprot
proteins
protein_family
BPI/LBP/Plunc superfamily
uniprot
proteins
pubmed
10079112
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16944957
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7615508
uniprot
proteins
pubmed
7654777
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P55058}. Nucleus {ECO:0000250|UniProtKB:P55058}. Note=Nuclear export is XPO1/CRM1-dependent. {ECO:0000250|UniProtKB:P55058}.
uniprot
proteins