ENY2
entrez
56943
canonical
uniprot
Q9NPA8
canonical
ensembl
ENSG00000120533
resolver
ensp
ENSP00000429713
resolver
ensp
ENSP00000429986
resolver
genesymbol
ENY2
resolver
hgnc
HGNC:24449
resolver
uniprot
B2RE52
resolver
uniprot
G3V117
resolver
uniprot_entry
ENY2_HUMAN
resolver
uniprot_sec
B2RE52
resolver
uniprot_sec
G3V117
resolver
amino_acid_sequence
MVVSKMNKDAQMRAAINQKLIETGERERLKELLRAKLIECGWKDQLKAHCKEVIKEKGLEHVTVDDLVAEITPKGRALVPDSVKKELLQRIRTFLAQHASL
uniprot
proteins
function
FUNCTION: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation (PubMed:18206972, PubMed:21746879). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820). {ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:21746879, ECO:0000269|PubMed:23591820}.
uniprot
proteins
mass_dalton
11529
uniprot
proteins
protein_family
ENY2 family
uniprot
proteins
pubmed
11438676
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
18206972
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21746879
uniprot
proteins
pubmed
22307388
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23591820
uniprot
proteins
pubmed
27601583
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
101
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03046, ECO:0000269|PubMed:22307388}. Note=Localization at the nuclear pore complex requires NUP153 and TPR. {ECO:0000269|PubMed:23591820}.
uniprot
proteins