Olr59
entrez
170816
canonical
uniprot
O88628
canonical
ensembl
ENSRNOG00000018606
resolver
ensembl
ENSRNOG00065031222
resolver
ensp
ENSRNOP00000092126
resolver
ensp
ENSRNOP00000105716
resolver
ensp
ENSRNOP00065044281
resolver
ensp
ENSRNOP00065044286
resolver
enst
ENSRNOT00000115264
resolver
enst
ENSRNOT00000169520
resolver
enst
ENSRNOT00065053843
resolver
enst
ENSRNOT00065053848
resolver
genesymbol
Olr59
resolver
genesymbol
Or51e2
resolver
genesymbol_syn
Olr59
resolver
genesymbol_syn
Psgr
resolver
uniprot
A0ABK0L6R5
resolver
uniprot_entry
A0ABK0L6R5_RAT
resolver
uniprot_entry
O51E2_RAT
resolver
amino_acid_sequence
MSSCNFTHATFMLIGIPGLEEAHFWFGFPLLSMYAVALFGNCIVVFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREITFDACLAQMFFIHALSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTVQIGMVALVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVHQDVMKLAYTDTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRAVLQLPSKSERAKAFGTCVSHIGVVLAFYVPLIGLSVVHRFGNSLDPIVHVLMGDVYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDIEAGGNT
uniprot
proteins
function
FUNCTION: Olfactory receptor activated by short-chain fatty acids (SCFA), such as acetate and propionate (propanoate). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha protein GNAL/G(olf), mediating activation of adenylate cyclase activity and increased production of cAMP, initiating a neuronal response that triggers the perception of a smell. Beyond its role in olfaction, may also be activated by steroid hormones and regulate cell proliferation. Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis. Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells. In response to SCFA, may positively regulate renin secretion and increase blood pressure (By similarity). Activated by L-lactate in glomus cells (By similarity). {ECO:0000250|UniProtKB:Q8VBV9, ECO:0000250|UniProtKB:Q9H255}.
uniprot
proteins
mass_dalton
35505
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11707321
uniprot
proteins
pubmed
9932290
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H255}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q9H255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..49; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9H255"; TRANSMEM 60..85; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9H255"; TRANSMEM 94..119; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9H255"; TRANSMEM 140..164; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9H255"; TRANSMEM 192..218; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9H255"; TRANSMEM 237..264; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9H255"; TRANSMEM 270..295; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9H255
uniprot
proteins