THTPA
entrez
79178
canonical
uniprot
Q9BU02
canonical
ensembl
ENSG00000259431
resolver
ensp
ENSP00000288014
resolver
ensp
ENSP00000384580
resolver
ensp
ENSP00000450459
resolver
ensp
ENSP00000451835
resolver
ensp
ENSP00000452465
resolver
enst
ENST00000554970
resolver
genesymbol
THTPA
resolver
hgnc
HGNC:18987
resolver
uniprot
D3DS50
resolver
uniprot
G3V4J3
resolver
uniprot
G3V5Q5
resolver
uniprot_entry
G3V5Q5_HUMAN
resolver
uniprot_entry
THTPA_HUMAN
resolver
uniprot_sec
D3DS50
resolver
uniprot_sec
G3V4J3
resolver
amino_acid_sequence
MAQGLIEVERKFLPGPGTEERLQELGGTLEYRVTFRDTYYDTPELSLMQADHWLRRREDSGWELKCPGAAGVLGPHTEYKELTAEPTIVAQLCKVLRADGLGAGDVAAVLGPLGLQEVASFVTKRSAWKLVLLGADEEEPQLRVDLDTADFGYAVGEVEALVHEEAEVPTALEKIHRLSSMLGVPAQETAPAKLIVYLQRFRPQDYQRLLEVNSSRERPQETEDPDHCLG
uniprot
proteins
ec_number
3.6.1.28
uniprot
proteins
function
FUNCTION: Hydrolase highly specific for thiamine triphosphate (ThTP). {ECO:0000269|PubMed:11827967, ECO:0000269|PubMed:23707715}.
uniprot
proteins
mass_dalton
25566
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="K->A: Mildly decreases enzyme activity."; /evidence="ECO:0000269|PubMed:23707715"; MUTAGEN 37; /note="D->A: Strongly decreases affinity for thiamine triphosphate and enzyme activity."; /evidence="ECO:0000269|PubMed:23707715"; MUTAGEN 39; /note="Y->A: Strongly decreases affinity for thiamine triphosphate and enzyme activity."; /evidence="ECO:0000269|PubMed:23707715"; MUTAGEN 53; /note="W->A: Strongly decreases affinity for thiamine triphosphate and enzyme activity."; /evidence="ECO:0000269|PubMed:23707715"; MUTAGEN 65; /note="K->A: Strongly decreases enzyme activity. No effect on affinity for thiamine triphosphate."; /evidence="ECO:0000269|PubMed:23707715"; MUTAGEN 79; /note="Y->A: Decreases enzyme activity."; /evidence="ECO:0000269|PubMed:23707715"; MUTAGEN 81; /note="E->A: Mildly decreases enzyme activity."; /evidence="ECO:0000269|PubMed:23707715"; MUTAGEN 147; /note="D->A: Strongly decreases affinity for thiamine triphosphate and enzyme activity."; /evidence="ECO:0000269|PubMed:23707715"; MUTAGEN 193; /note="K->A: Strongly decreases affinity for thiamine triphosphate and enzyme activity."; /evidence="ECO:0000269|PubMed:23707715
uniprot
proteins
protein_family
ThTPase family
uniprot
proteins
pubmed
11827967
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23707715
uniprot
proteins
sequence_length
230
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11827967}.
uniprot
proteins