DCTD
entrez
1635
canonical
uniprot
P32321
canonical
ensembl
ENSG00000129187
resolver
ensp
ENSP00000349576
resolver
ensp
ENSP00000398194
resolver
ensp
ENSP00000424017
resolver
ensp
ENSP00000578185
resolver
ensp
ENSP00000578189
resolver
ensp
ENSP00000596997
resolver
genesymbol
DCTD
resolver
hgnc
HGNC:2710
resolver
uniprot
B2R836
resolver
uniprot
D3DP49
resolver
uniprot
D3DP50
resolver
uniprot
Q5M7Z8
resolver
uniprot
Q9BVD8
resolver
uniprot_entry
DCTD_HUMAN
resolver
uniprot_sec
B2R836
resolver
uniprot_sec
D3DP49
resolver
uniprot_sec
D3DP50
resolver
uniprot_sec
Q5M7Z8
resolver
uniprot_sec
Q9BVD8
resolver
activity_regulation
ACTIVITY REGULATION: Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP. {ECO:0000269|PubMed:7685356}.
uniprot
proteins
amino_acid_sequence
MSEVSCKKRDDYLEWPEYFMAVAFLSAQRSKDPNSQVGACIVNSENKIVGIGYNGMPNGCSDDVLPWRRTAENKLDTKYPYVCHAELNAIMNKNSTDVKGCSMYVALFPCNECAKLIIQAGIKEVIFMSDKYHDSDEATAARLLFNMAGVTFRKFIPKCSKIVIDFDSINSRPSQKLQ
uniprot
proteins
ec_number
3.5.4.12
uniprot
proteins
function
FUNCTION: Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS (PubMed:7685356). Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate) (PubMed:33833118). Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP) (PubMed:33833118). {ECO:0000269|PubMed:33833118, ECO:0000269|PubMed:7685356}.
uniprot
proteins
mass_dalton
20016
uniprot
proteins
protein_family
Cytidine and deoxycytidylate deaminase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
33833118
uniprot
proteins
pubmed
7642519
uniprot
proteins
pubmed
7685356
uniprot
proteins
sequence_length
178
uniprot
proteins