ESR2
entrez
2100
canonical
uniprot
Q92731
canonical
ensembl
ENSG00000140009
resolver
ensp
ENSP00000267525
resolver
ensp
ENSP00000335551
resolver
ensp
ENSP00000343925
resolver
ensp
ENSP00000345616
resolver
ensp
ENSP00000351412
resolver
ensp
ENSP00000450488
resolver
ensp
ENSP00000450699
resolver
ensp
ENSP00000452426
resolver
genesymbol
ESR2
resolver
genesymbol
NR3A2
resolver
genesymbol_syn
ESR2
resolver
genesymbol_syn
ESTRB
resolver
genesymbol_syn
NR3A2
resolver
hgnc
HGNC:3468
resolver
uniprot
A0A348FV93
resolver
uniprot
A8K8K5
resolver
uniprot
F1D8N3
resolver
uniprot
G3V5M5
resolver
uniprot
O60608
resolver
uniprot
O60685
resolver
uniprot
O60702
resolver
uniprot
O60703
resolver
uniprot
O75583
resolver
uniprot
O75584
resolver
uniprot
Q0MWT5
resolver
uniprot
Q0MWT6
resolver
uniprot
Q0PTK2
resolver
uniprot
Q7LCB3
resolver
uniprot
Q86Z31
resolver
uniprot
Q9UEV6
resolver
uniprot
Q9UHD3
resolver
uniprot
Q9UQK9
resolver
uniprot_entry
A0A348FV93_HUMAN
resolver
uniprot_entry
ESR2_HUMAN
resolver
uniprot_entry
F1D8N3_HUMAN
resolver
uniprot_entry
Q0PTK2_HUMAN
resolver
uniprot_entry
Q7LCB3_HUMAN
resolver
uniprot_sec
A8K8K5
resolver
uniprot_sec
G3V5M5
resolver
uniprot_sec
O60608
resolver
uniprot_sec
O60685
resolver
uniprot_sec
O60702
resolver
uniprot_sec
O60703
resolver
uniprot_sec
O75583
resolver
uniprot_sec
O75584
resolver
uniprot_sec
Q0MWT5
resolver
uniprot_sec
Q0MWT6
resolver
uniprot_sec
Q86Z31
resolver
uniprot_sec
Q9UEV6
resolver
uniprot_sec
Q9UHD3
resolver
uniprot_sec
Q9UQK9
resolver
amino_acid_sequence
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
uniprot
proteins
disease_involvement
DISEASE: Ovarian dysgenesis 8 (ODG8) [MIM:618187]: An autosomal dominant form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. {ECO:0000269|PubMed:30113650}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). {ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:29261182, ECO:0000269|PubMed:30113650, ECO:0000269|PubMed:9325313}.; FUNCTION: [Isoform 2]: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. {ECO:0000269|PubMed:9671811}.
uniprot
proteins
mass_dalton
59216
uniprot
proteins
mutagenesis
MUTAGEN 87; /note="S->A: Enhances repression by activated ErbB2/ErbB3; when associated with A-105."; /evidence="ECO:0000269|PubMed:15862947"; MUTAGEN 87; /note="S->D: Abolishes repression by activated ErbB2/ErbB3; when associated with D-105."; /evidence="ECO:0000269|PubMed:15862947"; MUTAGEN 105; /note="S->A: Enhances repression by activated ErbB2/ErbB3; when associated with A-87."; /evidence="ECO:0000269|PubMed:15862947"; MUTAGEN 105; /note="S->D: Abolishes repression by activated ErbB2/ErbB3; when associated with D-87."; /evidence="ECO:0000269|PubMed:15862947
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-87 and Ser-105 recruits NCOA1. {ECO:0000269|PubMed:15862947}.
uniprot
proteins
protein_family
NR3 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10681503
uniprot
proteins
pubmed
10964723
uniprot
proteins
pubmed
11113208
uniprot
proteins
pubmed
11579095
uniprot
proteins
pubmed
12039952
uniprot
proteins
pubmed
12415108
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15047147
uniprot
proteins
pubmed
15199063
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15862947
uniprot
proteins
pubmed
16938840
uniprot
proteins
pubmed
19126643
uniprot
proteins
pubmed
19666546
uniprot
proteins
pubmed
20074560
uniprot
proteins
pubmed
29261182
uniprot
proteins
pubmed
30113650
uniprot
proteins
pubmed
8769313
uniprot
proteins
pubmed
9267036
uniprot
proteins
pubmed
9325313
uniprot
proteins
pubmed
9473491
uniprot
proteins
pubmed
9636657
uniprot
proteins
pubmed
9671811
uniprot
proteins
pubmed
9685228
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:19126643, ECO:0000269|PubMed:20074560}.
uniprot
proteins