Dcun1d5
entrez
315405
canonical
uniprot
Q5PPL2
canonical
ensembl
ENSRNOG00000008390
resolver
ensp
ENSRNOP00000058633
resolver
enst
ENSRNOT00000061916
resolver
genesymbol
Dcun1d5
resolver
uniprot_entry
DCNL5_RAT
resolver
amino_acid_sequence
MPVKKKRKAPGVAAAVAEDAGLKKCKISSYCRSQPPARLISGEEDFSRKKCLAWFYEYAGPDEVVGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEWLKGMTSLQCDCTEKLQSRFDFLRSQLNDISSFKNIYRYAFDFARDKDQRSLDIDTAKSMLALLLGRTWPLFSVFYQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDEFVEWQKIRQTS
uniprot
proteins
function
FUNCTION: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth. {ECO:0000250|UniProtKB:Q9BTE7}.
uniprot
proteins
mass_dalton
27568
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-41 is independent of cullin's interaction. Phosphorylated in response to both TICAM1 and MYD88 dependent Toll-like receptor (TLR) pathway activation (By similarity). Phosphorylated in response to IL1B stimulation (By similarity). {ECO:0000250|UniProtKB:Q9BTE7, ECO:0000250|UniProtKB:Q9CXV9}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BTE7}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9BTE7}. Note=Subcellular localization is independent of the interaction with cullins. {ECO:0000250|UniProtKB:Q9BTE7}.
uniprot
proteins