Adrm1
entrez
56436
canonical
uniprot
Q9JKV1
canonical
ensembl
ENSMUSG00000039041
resolver
ensp
ENSMUSP00000050076
resolver
enst
ENSMUST00000061437
resolver
genesymbol
Adrm1
resolver
genesymbol_syn
Gp110
resolver
uniprot
Q3UKZ8
resolver
uniprot
Q8BPH8
resolver
uniprot
Q922A7
resolver
uniprot_entry
ADRM1_MOUSE
resolver
uniprot_sec
Q3UKZ8
resolver
uniprot_sec
Q8BPH8
resolver
uniprot_sec
Q922A7
resolver
amino_acid_sequence
MTTSGALFPSLVPGSRGSSTKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGTVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNECLNNPPMPGSLGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPASSSSSSSRSQSAAVTPSSSTSSARATPAPSAPAAASATSPSPAPSSGNGTSTAASPTQPIQLSDLQSILATMNVPAGPGGSQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKSDPKEGDTKDKKDEEEDMSLD
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:18497827). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:18497827). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:18497827). Within the complex, functions as a proteasomal ubiquitin receptor (PubMed:18497827). Engages and thus activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation (By similarity). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (By similarity). {ECO:0000250|UniProtKB:Q16186, ECO:0000269|PubMed:18497827}.
uniprot
proteins
mass_dalton
42060
uniprot
proteins
post_translational_modification
PTM: Not N-glycosylated. {ECO:0000269|PubMed:15819879}.; PTM: Not O-glycosylated. {ECO:0000269|PubMed:15819879}.; PTM: Ubiquitinated by UBE3C in response to proteotoxic stress. {ECO:0000250|UniProtKB:Q16186}.
uniprot
proteins
protein_family
ADRM1 family
uniprot
proteins
pubmed
10919708
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15819879
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16815440
uniprot
proteins
pubmed
17139257
uniprot
proteins
pubmed
18497827
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15819879}. Nucleus {ECO:0000250|UniProtKB:Q16186}.
uniprot
proteins