CCDC6
entrez
8030
canonical
uniprot
Q16204
canonical
ensembl
ENSG00000108091
resolver
ensp
ENSP00000263102
resolver
enst
ENST00000263102
resolver
genesymbol
CCDC6
resolver
genesymbol_syn
D10S170
resolver
genesymbol_syn
TST1
resolver
hgnc
HGNC:18782
resolver
uniprot
Q05CP8
resolver
uniprot
Q15250
resolver
uniprot
Q6GSG7
resolver
uniprot_entry
CCDC6_HUMAN
resolver
uniprot_entry
Q05CP8_HUMAN
resolver
uniprot_sec
Q15250
resolver
uniprot_sec
Q6GSG7
resolver
amino_acid_sequence
MADSASESDTDGAGGNSSSSAAMQSSCSSTSGGGGGGGGGGGGGKSGGIVISPFRLEELTNRLASLQQENKVLKIELETYKLKCKALQEENRDLRKASVTIQARAEQEEEFISNTLFKKIQALQKEKETLAVNYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPVSAPPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREENLRLQRKLQREMERREALCRQLSESESSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGTSHGITRPSPRRSNSPDKFKRPTPPPSPNTQTPVQPPPPPPPPPMQPTVPSAATSQPTPSQHSAHPSSQP
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving CCDC6 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene. {ECO:0000269|PubMed:2406025}.
uniprot
proteins
function
FUNCTION: Acts as a structural scaffold that organizes free PP2Ac into a configuration that FBXO42 can recognize and ubiquitinate, leading to its proteasomal degradation (PubMed:41986709). Also interacts independently with PPP4C through a mechanism distinct from FBXO42-mediated ubiquitination (PubMed:41484364). {ECO:0000269|PubMed:41484364, ECO:0000269|PubMed:41986709}.
uniprot
proteins
mass_dalton
53291
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2406025
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
41484364
uniprot
proteins
pubmed
41986709
uniprot
proteins
pubmed
8058316
uniprot
proteins
sequence_length
474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000305}. Note=May be a cytoskeletal protein.
uniprot
proteins