Psmb6
entrez
19175
canonical
uniprot
Q60692
canonical
ensembl
ENSMUSG00000018286
resolver
ensp
ENSMUSP00000018430
resolver
ensp
ENSMUSP00000345836
resolver
enst
ENSMUST00000018430
resolver
genesymbol
Psmb6
resolver
genesymbol_syn
Lmp19
resolver
uniprot
Q3V240
resolver
uniprot
Q60693
resolver
uniprot
Q8BJX9
resolver
uniprot
Q91VH5
resolver
uniprot_entry
PSB6_MOUSE
resolver
uniprot_sec
Q3V240
resolver
uniprot_sec
Q60693
resolver
uniprot_sec
Q8BJX9
resolver
uniprot_sec
Q91VH5
resolver
amino_acid_sequence
MAAALAVRRAGSAPAFGPEALTPDWENREVSTGTTIMAVQFNGGVVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKDECLQFTANALALAMERDGSSGGVIRLAAIQESGVERQVLLGDQIPKFTIATLPPP
uniprot
proteins
ec_number
3.4.25.1
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolyzing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues. {ECO:0000269|PubMed:16581775, ECO:0000269|PubMed:22341445}.
uniprot
proteins
mass_dalton
25379
uniprot
proteins
protein_family
Peptidase T1B family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16581775
uniprot
proteins
pubmed
16857966
uniprot
proteins
pubmed
17521679
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22341445
uniprot
proteins
pubmed
7797265
uniprot
proteins
sequence_length
238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P28072}. Nucleus {ECO:0000250|UniProtKB:P28072}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000250|UniProtKB:P28072}.
uniprot
proteins