C5
entrez
727
canonical
uniprot
P01031
canonical
ensembl
ENSG00000106804
resolver
ensp
ENSP00000223642
resolver
ensp
ENSP00000512521
resolver
enst
ENST00000223642
resolver
enst
ENST00000696281
resolver
genesymbol
C5
resolver
genesymbol_syn
CPAMD4
resolver
hgnc
HGNC:1331
resolver
uniprot
A0A8Q3SID6
resolver
uniprot
Q14CJ0
resolver
uniprot
Q27I61
resolver
uniprot
Q59GS8
resolver
uniprot_entry
A0A8Q3SID6_HUMAN
resolver
uniprot_entry
CO5_HUMAN
resolver
uniprot_entry
Q59GS8_HUMAN
resolver
uniprot_sec
Q14CJ0
resolver
uniprot_sec
Q27I61
resolver
activity_regulation
ACTIVITY REGULATION: [Complement C5b]: Membrane attack complex (MAC) assembly is inhibited by CD59, thereby protecting self-cells from damage during complement activation (PubMed:36797260). MAC assembly is also inhibited by clusterin (CLU) chaperones that inhibit polymerization of C9 (PubMed:34667172). {ECO:0000269|PubMed:34667172, ECO:0000269|PubMed:36797260}.
uniprot
proteins
amino_acid_sequence
MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC
uniprot
proteins
disease_involvement
DISEASE: Complement component 5 deficiency (C5D) [MIM:609536]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. {ECO:0000269|PubMed:7730648}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele. {ECO:0000269|PubMed:15995705}.
uniprot
proteins
function
FUNCTION: Precursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:6554279). Activated downstream of classical, alternative, lectin and GZMK complement pathways (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:39914456, PubMed:39814882, PubMed:6554279). {ECO:0000269|PubMed:12878586, ECO:0000269|PubMed:18204047, ECO:0000269|PubMed:30643019, ECO:0000269|PubMed:39814882, ECO:0000269|PubMed:39914456, ECO:0000269|PubMed:6554279}.; FUNCTION: [Complement C5b]: Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:26841837, PubMed:27052168, PubMed:30552328, PubMed:30643019). Complement C5b is generated following cleavage by C5 convertase and initiates formation of the MAC complex: C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 (PubMed:30552328, PubMed:30643019). During MAC complex assembly, the C5b6 subcomplex, composed of complement C5b and C6, associates with the outer leaflet of target cell membrane, reducing the energy for membrane bending (PubMed:30552328, PubMed:32569291). {ECO:0000269|PubMed:26841837, ECO:0000269|PubMed:27052168, ECO:0000269|PubMed:30552328, ECO:0000269|PubMed:30643019, ECO:0000269|PubMed:32569291}.; FUNCTION: [C5a anaphylatoxin]: Mediator of local inflammatory process released following cleavage by C5 convertase (PubMed:8182049, PubMed:9553099). Acts by binding to its receptor (C5AR1 or C5AR2), activating G protein-coupled receptor signaling and inducing a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:36806352, PubMed:37852260, PubMed:37169960, PubMed:8182049, PubMed:9553099). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation (PubMed:342601, PubMed:37852260, PubMed:37169960, PubMed:5765461, PubMed:8182049, PubMed:9553099). {ECO:0000269|PubMed:342601, ECO:0000269|PubMed:36806352, ECO:0000269|PubMed:37169960, ECO:0000269|PubMed:37852260, ECO:0000269|PubMed:5765461, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}.
uniprot
proteins
mass_dalton
188305
uniprot
proteins
post_translational_modification
PTM: C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond (PubMed:106884). During activation of the complement systems, the alpha chain is cleaved into C5a and C5b by the C5 convertase: C5b stays linked to the beta chain, while C5a is released in the plasma (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:624565). The alpha chain is cleaved by the serine protease complement C2b component of the C5 convertase to generate C5a and C5b following activation by the classical, lectin and GZMK complement systems (PubMed:12878586, PubMed:18204047). The alpha chain is cleaved by CFB component of the C5 convertase to generate C5a and C5b following activation by the alternative complement system (PubMed:30643019, PubMed:624565, PubMed:6554279). {ECO:0000269|PubMed:106884, ECO:0000269|PubMed:12878586, ECO:0000269|PubMed:18204047, ECO:0000269|PubMed:30643019, ECO:0000269|PubMed:624565, ECO:0000269|PubMed:6554279}.
uniprot
proteins
pubmed
106884
uniprot
proteins
pubmed
12878586
uniprot
proteins
pubmed
15488949
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15598652
uniprot
proteins
pubmed
15778377
uniprot
proteins
pubmed
15995705
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
18204047
uniprot
proteins
pubmed
18536718
uniprot
proteins
pubmed
1984448
uniprot
proteins
pubmed
1996961
uniprot
proteins
pubmed
20133685
uniprot
proteins
pubmed
21217642
uniprot
proteins
pubmed
22028381
uniprot
proteins
pubmed
22500023
uniprot
proteins
pubmed
22832194
uniprot
proteins
pubmed
24521109
uniprot
proteins
pubmed
2579066
uniprot
proteins
pubmed
26841837
uniprot
proteins
pubmed
27018802
uniprot
proteins
pubmed
27052168
uniprot
proteins
pubmed
2730871
uniprot
proteins
pubmed
2784981
uniprot
proteins
pubmed
30552328
uniprot
proteins
pubmed
30643019
uniprot
proteins
pubmed
31061395
uniprot
proteins
pubmed
31871188
uniprot
proteins
pubmed
32569291
uniprot
proteins
pubmed
3365401
uniprot
proteins
pubmed
3408713
uniprot
proteins
pubmed
342601
uniprot
proteins
pubmed
34667172
uniprot
proteins
pubmed
36797260
uniprot
proteins
pubmed
36806352
uniprot
proteins
pubmed
37169960
uniprot
proteins
pubmed
37852260
uniprot
proteins
pubmed
39814882
uniprot
proteins
pubmed
39914456
uniprot
proteins
pubmed
5765461
uniprot
proteins
pubmed
624565
uniprot
proteins
pubmed
6554279
uniprot
proteins
pubmed
690134
uniprot
proteins
pubmed
7730648
uniprot
proteins
pubmed
8182049
uniprot
proteins
pubmed
9007977
uniprot
proteins
pubmed
9188742
uniprot
proteins
pubmed
9553099
uniprot
proteins
sequence_length
1676
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:106884}.; SUBCELLULAR LOCATION: [Complement C5b]: Secreted {ECO:0000269|PubMed:106884}. Target cell membrane {ECO:0000269|PubMed:30552328, ECO:0000269|PubMed:30643019, ECO:0000269|PubMed:31061395, ECO:0000269|PubMed:32569291}. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells. {ECO:0000269|PubMed:30643019, ECO:0000269|PubMed:31061395}.; SUBCELLULAR LOCATION: [C5a anaphylatoxin]: Secreted {ECO:0000269|PubMed:690134}.
uniprot
proteins