Pla1a
entrez
85031
canonical
uniprot
Q8VI78
canonical
ensembl
ENSMUSG00000002847
resolver
ensp
ENSMUSP00000002926
resolver
ensp
ENSMUSP00000233965
resolver
ensp
ENSMUSP00000350142
resolver
enst
ENSMUST00000002926
resolver
genesymbol
Pla1a
resolver
genesymbol_syn
Pspla1
resolver
uniprot
E9QN71
resolver
uniprot
Q99J51
resolver
uniprot_entry
PLA1A_MOUSE
resolver
uniprot_sec
E9QN71
resolver
uniprot_sec
Q99J51
resolver
amino_acid_sequence
MRPGLWETCFWLWGPLLWLSIGSSGNVPPTTQPKCTDFQSANLLRGTNLKVQFLLFTPSDPSCGQLVEEGSDIRSSEFNASLGTKVIIHGFRALGTKPSWIDKFISAVLRAADANVIAVDWVYGSTGVYYSAVENVVKLSLEISRFLSKLLELGVSESSIHIIGVSLGAHVGGMVGHFYKGQLGQITGLDPAGPEYTRASLEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPAFFHAGYNYLICDHMRAVHLYISALENTCPLMAFPCASYKAFLAGDCLDCFNPFLLSCPRIGLVERGGVMIEPLPKEVKVYLLTTSSAPYCVHHSLVEFYLKEKRKKDTSIEVTFLSNNVTSSVKITIPKQQLEGRGVMAHPNPQCQINQVKLKFQVSSRVWRKDRTPVVGTFCTAPLPVNDSKKTVCIPEPVRLQAGVPAFQDLKIACV
uniprot
proteins
ec_number
3.1.1.111
uniprot
proteins
function
FUNCTION: Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (By similarity). Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production. Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (By similarity). {ECO:0000250|UniProtKB:P97535, ECO:0000250|UniProtKB:Q53H76}.
uniprot
proteins
mass_dalton
49984
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
Lipase family
uniprot
proteins
pubmed
11210182
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P97535}.
uniprot
proteins