Gria2
entrez
29627
canonical
uniprot
P19491
canonical
ensembl
ENSRNOG00000054204
resolver
ensp
ENSRNOP00000069094
resolver
ensp
ENSRNOP00000072906
resolver
genesymbol
Gria2
resolver
genesymbol_syn
GluA2
resolver
genesymbol_syn
Glur2
resolver
uniprot
Q9R174
resolver
uniprot_entry
GRIA2_RAT
resolver
uniprot_sec
Q9R174
resolver
amino_acid_sequence
MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNPQNINPSSSQNSQNFATYKEGYNVYGIESVKI
uniprot
proteins
function
FUNCTION: Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:12015593, PubMed:12730367, PubMed:15591246, PubMed:2166337, PubMed:21846932, PubMed:9351977). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium (PubMed:11773314, PubMed:12501192, PubMed:12730367, PubMed:12872125, PubMed:16483599, PubMed:1653450, PubMed:17018279, PubMed:19946266). The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist (PubMed:12015593, PubMed:16192394, PubMed:17018279, PubMed:19946266). In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (PubMed:21172611). Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (PubMed:16037816). {ECO:0000250|UniProtKB:P42262, ECO:0000269|PubMed:11773314, ECO:0000269|PubMed:12015593, ECO:0000269|PubMed:12501192, ECO:0000269|PubMed:12730367, ECO:0000269|PubMed:12872125, ECO:0000269|PubMed:15591246, ECO:0000269|PubMed:16037816, ECO:0000269|PubMed:16192394, ECO:0000269|PubMed:16483599, ECO:0000269|PubMed:1653450, ECO:0000269|PubMed:17018279, ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21172611, ECO:0000269|PubMed:2166337, ECO:0000269|PubMed:21846932, ECO:0000269|PubMed:9351977}.
uniprot
proteins
mass_dalton
98688
uniprot
proteins
mutagenesis
MUTAGEN 504; /note="L->Y: Promotes dimerization. Strongly reduced desensitization."; /evidence="ECO:0000269|PubMed:12015593"; MUTAGEN 775; /note="N->D: Increases rate of desensitization."; /evidence="ECO:0000269|PubMed:12015593"; MUTAGEN 851..852; /note="NP->AA: Strongly reduces interaction with NSF."; /evidence="ECO:0000269|PubMed:9697855"; MUTAGEN 875; /note="V->Y: Almost abolishes interaction with IQSEC1; when associated with V-876. Abolishes activation of ARF6 by IQSEC1; when associated with V-876."; /evidence="ECO:0000269|PubMed:20547133"; MUTAGEN 876; /note="Y->A: Strongly decreases interaction with IQSEC1. Abolishes activation of ARF6 by IQSEC1."; /evidence="ECO:0000269|PubMed:20547133"; MUTAGEN 876; /note="Y->F: No effect on interaction with IQSEC1."; /evidence="ECO:0000269|PubMed:20547133"; MUTAGEN 876; /note="Y->V: Almost abolishes interaction with IQSEC1; when associated with Y-875. Abolishes activation of ARF6 by IQSEC1; when associated with Y-875."; /evidence="ECO:0000269|PubMed:20547133
uniprot
proteins
post_translational_modification
PTM: Palmitoylated (By similarity). Depalmitoylated upon L-glutamate stimulation (By similarity). Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression (By similarity). In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P23819}.; PTM: Phosphorylation at Tyr-876 is required for interaction with IQSEC1 and ARF6 activation, which in turn triggers AMPAR internalization for persistent synaptic depression. {ECO:0000269|PubMed:20547133}.; PTM: Ubiquitinated by RNF167, leading to its degradation. {ECO:0000250|UniProtKB:P42262}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:P23819}.
uniprot
proteins
protein_family
GRIA2 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
10027300
uniprot
proteins
pubmed
10414981
uniprot
proteins
pubmed
11086992
uniprot
proteins
pubmed
11773314
uniprot
proteins
pubmed
12015593
uniprot
proteins
pubmed
12215417
uniprot
proteins
pubmed
12501192
uniprot
proteins
pubmed
12593667
uniprot
proteins
pubmed
12657670
uniprot
proteins
pubmed
12730367
uniprot
proteins
pubmed
12872125
uniprot
proteins
pubmed
14687553
uniprot
proteins
pubmed
15240807
uniprot
proteins
pubmed
15591246
uniprot
proteins
pubmed
16037816
uniprot
proteins
pubmed
16192394
uniprot
proteins
pubmed
16483599
uniprot
proteins
pubmed
1653450
uniprot
proteins
pubmed
16630835
uniprot
proteins
pubmed
16793768
uniprot
proteins
pubmed
1699275
uniprot
proteins
pubmed
1699567
uniprot
proteins
pubmed
17018279
uniprot
proteins
pubmed
1717158
uniprot
proteins
pubmed
18817736
uniprot
proteins
pubmed
19234459
uniprot
proteins
pubmed
19265014
uniprot
proteins
pubmed
19946266
uniprot
proteins
pubmed
20547133
uniprot
proteins
pubmed
21172611
uniprot
proteins
pubmed
21317873
uniprot
proteins
pubmed
21496646
uniprot
proteins
pubmed
2166337
uniprot
proteins
pubmed
2168579
uniprot
proteins
pubmed
21846932
uniprot
proteins
pubmed
25103405
uniprot
proteins
pubmed
27756895
uniprot
proteins
pubmed
8848293
uniprot
proteins
pubmed
9069286
uniprot
proteins
pubmed
9351977
uniprot
proteins
pubmed
9697855
uniprot
proteins
pubmed
9804426
uniprot
proteins
sequence_length
883
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P42262}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P42262}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P42262}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P42262}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P23819}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23819}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (PubMed:19265014). Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). {ECO:0000250|UniProtKB:P23819, ECO:0000269|PubMed:19265014}.
uniprot
proteins
transmembrane_region
TRANSMEM 544..564; /note="Helical"; TRANSMEM 617..637; /note="Helical"; TRANSMEM 813..833; /note="Helical; Name=M4
uniprot
proteins