HGF
entrez
3082
canonical
uniprot
P14210
canonical
ensembl
ENSG00000019991
resolver
ensp
ENSP00000222390
resolver
ensp
ENSP00000389854
resolver
ensp
ENSP00000391238
resolver
ensp
ENSP00000408270
resolver
ensp
ENSP00000413829
resolver
genesymbol
HGF
resolver
genesymbol_syn
HPTA
resolver
hgnc
HGNC:4893
resolver
uniprot
A1L3U6
resolver
uniprot
Q02935
resolver
uniprot
Q13494
resolver
uniprot
Q14519
resolver
uniprot
Q3KRB2
resolver
uniprot
Q8TCE2
resolver
uniprot
Q9BYL9
resolver
uniprot
Q9BYM0
resolver
uniprot
Q9UDU6
resolver
uniprot_entry
HGF_HUMAN
resolver
uniprot_sec
A1L3U6
resolver
uniprot_sec
Q02935
resolver
uniprot_sec
Q13494
resolver
uniprot_sec
Q14519
resolver
uniprot_sec
Q3KRB2
resolver
uniprot_sec
Q8TCE2
resolver
uniprot_sec
Q9BYL9
resolver
uniprot_sec
Q9BYM0
resolver
uniprot_sec
Q9UDU6
resolver
amino_acid_sequence
MWVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTCADNTMNDTDVPLETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRENYCRNPDGSESPWCFTTDPNIRVGYCSQIPNCDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNMEDLHRHIFWEPDASKLNENYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTRTNIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRDLKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARPAVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHRGKVTLNESEICAGAEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKIILTYKVPQS
uniprot
proteins
disease_involvement
DISEASE: Deafness, autosomal recessive, 39 (DFNB39) [MIM:608265]: A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269|PubMed:19576567}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed:20624990). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (PubMed:15167892, PubMed:20977675). Activates MAPK signaling following TMPRSS13 cleavage and activation (PubMed:20977675). {ECO:0000269|PubMed:15167892, ECO:0000269|PubMed:20624990, ECO:0000269|PubMed:20977675}.
uniprot
proteins
mass_dalton
83134
uniprot
proteins
mutagenesis
MUTAGEN 494; /note="R->Q: Loss of activity due to absence of proteolytic cleavage."; /evidence="ECO:0000269|PubMed:1280830
uniprot
proteins
post_translational_modification
PTM: The single-chain precursor undergoes proteolytic processing by TMPRSS13 resulting in an active two-chain form (PubMed:20977675). The single-chain precursor undergoes proteolytic processing by HGFAC resulting in an active two-chain form (PubMed:8226803). {ECO:0000269|PubMed:20977675, ECO:0000269|PubMed:8226803}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
protein_family
Plasminogen subfamily
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
1280830
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
1321034
uniprot
proteins
pubmed
1482348
uniprot
proteins
pubmed
15167892
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1720571
uniprot
proteins
pubmed
1824873
uniprot
proteins
pubmed
1826653
uniprot
proteins
pubmed
1826837
uniprot
proteins
pubmed
1831266
uniprot
proteins
pubmed
1831432
uniprot
proteins
pubmed
1832556
uniprot
proteins
pubmed
19576567
uniprot
proteins
pubmed
20624990
uniprot
proteins
pubmed
20977675
uniprot
proteins
pubmed
2145836
uniprot
proteins
pubmed
22242148
uniprot
proteins
pubmed
2528952
uniprot
proteins
pubmed
2531289
uniprot
proteins
pubmed
8226803
uniprot
proteins
pubmed
8662798
uniprot
proteins
pubmed
9493272
uniprot
proteins
pubmed
9817840
uniprot
proteins
sequence_length
728
uniprot
proteins