P0C927
uniprot
P0C927
canonical
amino_acid_sequence
MDQQSSDEDADTDFDTQIIIQQSLLDAYKPELTGRTPEDERSQSFSSEDYKKIVEAIETVKYSSYPRPSKEDALASFAKYHPAFDEANGSGWLPLHKAAVQLNKNILEITLNASKPSAWEQTTRNGETPLFLAVSSSLLENAHFLLLNGCDPNAKNFEGNSPLLTAVLKDSYDMATLLINHGANVNLRCANERTALHEAAKLGRQDMVKLMLSSGANPDARSSYGFTPLALAAQGGHTETMQLLLQKGRADVHSQASDSSSVLLEAVRGGDPDSVSLLLEYGADANIPKSSGHLPIHVAADKGHFLALKVLVPVTDIAAIKRSGISPLHCAAAGAHPQCLDLLIRAGFDVNFMLDQRVRKHYDDQRKSALYFAVSNGDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELINLLLRHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGERVHRCCTFEGWTSTVIKDTMFCEVITLSWLQHLSGKVVRVMLDYVDQVQICSKLKAVLEKQKLWPEIHVILTNPRSLQHLCRLKIRKCMGRLRLRCPVFMSFLPLPNLLKAYVLYKEYDLYGQGSSTGT
uniprot
proteins
function
FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Plays a role in the inhibition of cardiomyocyte nuclear proliferation by mediating the ubiquitination and degradation of MAPRE2. {ECO:0000250|UniProtKB:Q8C6Y6}.
uniprot
proteins
mass_dalton
66181
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
Ankyrin SOCS box (ASB) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
596
uniprot
proteins