Actg2
entrez
11468
canonical
uniprot
P63268
canonical
ensembl
ENSMUSG00000059430
resolver
ensp
ENSMUSP00000074658
resolver
ensp
ENSMUSP00000113552
resolver
enst
ENSMUST00000075161
resolver
enst
ENSMUST00000121731
resolver
genesymbol
Actg2
resolver
genesymbol_syn
Acta3
resolver
genesymbol_syn
Actsg
resolver
uniprot
P12718
resolver
uniprot
Q3UJ36
resolver
uniprot_entry
ACTH_MOUSE
resolver
uniprot_entry
Q3UJ36_MOUSE
resolver
uniprot_sec
P12718
resolver
amino_acid_sequence
MCEEETTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKPEYDEAGPSIVHRKCF
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
uniprot
proteins
mass_dalton
41877
uniprot
proteins
post_translational_modification
PTM: Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization. {ECO:0000269|PubMed:23911929}.; PTM: Monomethylation at Lys-85 (K85me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. {ECO:0000250|UniProtKB:P68134}.; PTM: Methylated at His-74 by SETD3. {ECO:0000250|UniProtKB:P63267}.; PTM: [Actin, gamma-enteric smooth muscle, intermediate form]: N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP. {ECO:0000250|UniProtKB:P62737}.
uniprot
proteins
protein_family
Actin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23911929
uniprot
proteins
pubmed
24337657
uniprot
proteins
pubmed
2747639
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
uniprot
proteins