TMUB1
entrez
83590
canonical
uniprot
Q9BVT8
canonical
ensembl
ENSG00000164897
resolver
ensp
ENSP00000297533
resolver
ensp
ENSP00000376565
resolver
ensp
ENSP00000417519
resolver
ensp
ENSP00000418709
resolver
ensp
ENSP00000419214
resolver
ensp
ENSP00000543709
resolver
ensp
ENSP00000543710
resolver
ensp
ENSP00000543711
resolver
ensp
ENSP00000543712
resolver
ensp
ENSP00000543713
resolver
ensp
ENSP00000594941
resolver
ensp
ENSP00000594942
resolver
enst
ENST00000297533
resolver
enst
ENST00000392818
resolver
enst
ENST00000462940
resolver
enst
ENST00000476627
resolver
enst
ENST00000482202
resolver
enst
ENST00000873650
resolver
enst
ENST00000873651
resolver
enst
ENST00000873652
resolver
enst
ENST00000873653
resolver
enst
ENST00000873654
resolver
enst
ENST00000924882
resolver
enst
ENST00000924883
resolver
genesymbol
TMUB1
resolver
genesymbol_syn
C7orf21
resolver
genesymbol_syn
DULP
resolver
genesymbol_syn
HOPS
resolver
hgnc
HGNC:21709
resolver
uniprot
D3DX06
resolver
uniprot
Q53AQ2
resolver
uniprot_entry
TMUB1_HUMAN
resolver
uniprot_sec
D3DX06
resolver
uniprot_sec
Q53AQ2
resolver
amino_acid_sequence
MTLIEGVGDEVTVLFSVLACLLVLALAWVSTHTAEGGDPLPQPSGTPTPSQPSAAMAATDSMRGEAPGAETPSLRHRGQAAQPEPSTGFTATPPAPDSPQEPLVLRLKFLNDSEQVARAWPHDTIGSLKRTQFPGREQQVRLIYQGQLLGDDTQTLGSLHLPPNCVLHCHVSTRVGPPNPPCPPGSEPGPSGLEIGSLLLPLLLLLLLLLWYCQIQYRPFFPLTATLGLAGFTLLLSLLAFAMYRP
uniprot
proteins
function
FUNCTION: Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (PubMed:21343306). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as a negative regulator of hepatocyte growth during regeneration (By similarity). {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000250|UniProtKB:Q9JMG3, ECO:0000269|PubMed:21343306}.; FUNCTION: [iHOPS]: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity). {ECO:0000250|UniProtKB:Q9JMG3}.
uniprot
proteins
mass_dalton
26261
uniprot
proteins
post_translational_modification
PTM: [iHOPS]: Processed by regulated intramembrane proteolysis (RIP)in the N-terminus to release iHOPS from membranes (By similarity). {ECO:0000250|UniProtKB:Q9JMG3}.
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16014383
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19254477
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21343306
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24240191
uniprot
proteins
sequence_length
246
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9JMG3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JMG3}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9JMG3}. Recycling endosome {ECO:0000250|UniProtKB:Q53AQ4}. Cytoplasm {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9JMG3}.; SUBCELLULAR LOCATION: [iHOPS]: Cytoplasm {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000250|UniProtKB:Q9JMG3}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus {ECO:0000250|UniProtKB:Q9JMG3}. Note=iHOPS is proposed to be the shuttling form across different cellular compartments. XPO1-dependent exported from the nucleus in dividing cells. Predominantly nuclear during growth arrest. {ECO:0000250|UniProtKB:Q9JMG3}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 195..215; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 221..241; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins