GPKOW
entrez
27238
canonical
uniprot
Q92917
canonical
ensembl
ENSG00000068394
resolver
ensembl
ENSG00000292204
resolver
ensp
ENSP00000156109
resolver
ensp
ENSP00000518004
resolver
enst
ENST00000156109
resolver
enst
ENST00000710028
resolver
genesymbol
GPKOW
resolver
genesymbol_syn
GPATC5
resolver
genesymbol_syn
GPATCH5
resolver
genesymbol_syn
T54
resolver
hgnc
HGNC:30677
resolver
uniprot
Q59EK5
resolver
uniprot
Q9BQA8
resolver
uniprot_entry
GPKOW_HUMAN
resolver
uniprot_sec
Q59EK5
resolver
uniprot_sec
Q9BQA8
resolver
amino_acid_sequence
MADSKEGVLPLTAASTAPISFGFTRTSARRRLADSGDGAGPSPEEKDFLKTVEGRELQSVKPQEAPKELVIPLIQNGHRRQPPARPPGPSTDTGALADGVVSQAVKELIAESKKSLEERENAGVDPTLAIPMIQKGCTPSGEGADSEPRAETVPEEANYEAVPVEAYGLAMLRGMGWKPGEGIGRTFNQVVKPRVNSLRPKGLGLGANLTEAQALTPTGPSRMPRPDEEQEKDKEDQPQGLVPGGAVVVLSGPHRGLYGKVEGLDPDNVRAMVRLAVGSRVVTVSEYYLRPVSQQEFDKNTLDLRQQNGTASSRKTLWNQELYIQQDNSERKRKHLPDRQDGPAAKSEKAAPRSQHWLHRDLRVRFVDNMYKGGQYYNTKMIIEDVLSPDTCVCRTDEGRVLEGLREDMLETLVPKAEGDRVMVVLGPQTGRVGHLLSRDRARSRALVQLPRENQVVELHYDAICQYMGPSDTDDD
uniprot
proteins
function
FUNCTION: RNA-binding protein involved in pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:25296192, ECO:0000305|PubMed:33509932}.
uniprot
proteins
mass_dalton
52229
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="S->A: Reduced phosphorylation. Significant loss of phosphorylation and increased RNA-binding; when associated with A-316."; /evidence="ECO:0000269|PubMed:21880142"; MUTAGEN 176..177; /note="GW->AA: Significant loss of interaction with DHX16. No loss of pre-mRNA splicing activity. Able to suppress the splicing defect observed in dominant-negative DHX16 mutant expressing cells."; /evidence="ECO:0000269|PubMed:25296192"; MUTAGEN 259..260; /note="GK->AA: No loss of interaction with DHX16. Reduced pre-mRNA splicing activity. Decreased ability to suppress the splicing defect observed in dominant-negative DHX16 mutant expressing cells."; /evidence="ECO:0000269|PubMed:25296192"; MUTAGEN 316; /note="T->A: Reduced phosphorylation. Significant loss of phosphorylation and increased RNA-binding; when associated with A-27."; /evidence="ECO:0000269|PubMed:21880142
uniprot
proteins
post_translational_modification
PTM: Phosphorylation regulates its ability to bind RNA. {ECO:0000269|PubMed:21880142}.
uniprot
proteins
protein_family
MOS2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16271871
uniprot
proteins
pubmed
16491121
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21880142
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25296192
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
33509932
uniprot
proteins
pubmed
8938429
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21880142, ECO:0000269|PubMed:25296192}.
uniprot
proteins