Lyve1
entrez
114332
canonical
uniprot
Q8BHC0
canonical
ensembl
ENSMUSG00000030787
resolver
ensp
ENSMUSP00000033050
resolver
enst
ENSMUST00000033050
resolver
genesymbol
Lyve1
resolver
genesymbol_syn
Crsbp1
resolver
genesymbol_syn
Xlkd1
resolver
uniprot
Q3TUC1
resolver
uniprot
Q99NE4
resolver
uniprot_entry
LYVE1_MOUSE
resolver
uniprot_sec
Q3TUC1
resolver
uniprot_sec
Q99NE4
resolver
amino_acid_sequence
MLQHTSLVLLLASIWTTRHPVQGADLVQDLSISTCRIMGVALVGRNKNPQMNFTEANEACKMLGLTLASRDQVESAQKSGFETCSYGWVGEQFSVIPRIFSNPRCGKNGKGVLIWNAPSSQKFKAYCHNSSDTWVNSCIPEIVTTFYPVLDTQTPATEFSVSSSAYLASSPDSTTPVSATTRAPPLTSMARKTKKICITEVYTEPITMATETEAFVASGAAFKNEAAGFGGVPTALLVLALLFFGAAAVLAVCYVKRYVKAFPFTTKNQQKEMIETKVVKEEKADDVNANEESKKTIKNPEEAKSPPKTTVRCLEAEV
uniprot
proteins
function
FUNCTION: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:10187853). Binds to pericellular hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (By similarity). {ECO:0000250|UniProtKB:Q9Y5Y7, ECO:0000269|PubMed:10187853}.
uniprot
proteins
mass_dalton
34574
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
10037799
uniprot
proteins
pubmed
10187853
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17330941
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28179430
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10187853}; Single-pass type I membrane protein {ECO:0000269|PubMed:10187853}. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.
uniprot
proteins
transmembrane_region
TRANSMEM 235..255; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins