Slc29a2
entrez
65194
canonical
uniprot
O54699
canonical
ensembl
ENSRNOG00000020025
resolver
ensp
ENSRNOP00000027178
resolver
ensp
ENSRNOP00000106197
resolver
enst
ENSRNOT00000135468
resolver
genesymbol
Slc29a2
resolver
genesymbol_syn
Ent2
resolver
uniprot
A0ABK0LV63
resolver
uniprot_entry
A0ABK0LV63_RAT
resolver
uniprot_entry
S29A2_RAT
resolver
amino_acid_sequence
MAHGNAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQGRLAGTNSSAETPSTNHTSPTDTFNFNNWVTLLSQLPLLLFTLLNSFLYQCIPESVRILGSLLAILLLFALTAALVKVDLSPGLFFSITMASVWFINSFCAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLTSLASGVDPQTSALGYFITPCVGILLSIICYLSLPHLKFARYYLTKKPQAPVQELETKAELLGADEKNGIPVSPQQAGPTLDLDPEKELELGLEEPQKPGKPSVFVVFRKIWLTALCLVLVFTVTLSVFPAITAMVTTSSNSPGKWSQFFNPICCFLLFNVMDWLGRSLTSYFLWPDEDSQLLPLLVCLRFLFVPLFMLCHVPQRARLPIIFWQDAYFITFMLLFAISNGYFVSLTMCLAPRQVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL
uniprot
proteins
function
FUNCTION: Bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:18048066, PubMed:9353301). Functions as a Na(+)-independent, passive transporter (By similarity). Involved in the transport of nucleosides such as inosine, adenosine, uridine, thymidine, cytidine and guanosine (PubMed:9353301). Also mediates nicotinamide uptake supporting homeostasis and modulating its biological activities (By similarity). Can also transport urate (By similarity). Also able to transport purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:18048066). Involved in nucleoside transport at basolateral membrane of kidney cells, allowing liver absorption of nucleoside metabolites (By similarity). Mediates apical nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier (PubMed:23639800). Mediates both the influx and efflux of hypoxanthine in skeletal muscle microvascular endothelial cells to control the amount of intracellular hypoxanthine available for xanthine oxidase-mediated ROS production (PubMed:18048066). {ECO:0000250|UniProtKB:Q14542, ECO:0000269|PubMed:18048066, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:9353301}.
uniprot
proteins
mass_dalton
50265
uniprot
proteins
protein_family
SLC29A/ENT transporter (TC 2.A.57) family
uniprot
proteins
pubmed
18048066
uniprot
proteins
pubmed
23639800
uniprot
proteins
pubmed
9353301
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:23639800}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q14542}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q14542}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the apical membrane of Sertoli cells. {ECO:0000269|PubMed:23639800}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 69..93; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 98..116; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 125..143; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 161..185; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 292..311; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 324..342; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 360..378; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 394..413; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 432..452; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins