Ch25h
entrez
309527
canonical
uniprot
Q4QQV7
canonical
ensembl
ENSRNOG00000019141
resolver
ensembl
ENSRNOG00055031324
resolver
ensembl
ENSRNOG00065031014
resolver
ensp
ENSRNOP00000025856
resolver
ensp
ENSRNOP00000101918
resolver
ensp
ENSRNOP00000103488
resolver
ensp
ENSRNOP00000104254
resolver
ensp
ENSRNOP00000104779
resolver
ensp
ENSRNOP00000105170
resolver
ensp
ENSRNOP00000106730
resolver
ensp
ENSRNOP00000106856
resolver
ensp
ENSRNOP00000109805
resolver
ensp
ENSRNOP00055044867
resolver
ensp
ENSRNOP00065043944
resolver
enst
ENSRNOT00000025856
resolver
enst
ENSRNOT00000129026
resolver
enst
ENSRNOT00000135840
resolver
enst
ENSRNOT00000141753
resolver
enst
ENSRNOT00000155972
resolver
enst
ENSRNOT00000157228
resolver
enst
ENSRNOT00000157940
resolver
enst
ENSRNOT00000158933
resolver
enst
ENSRNOT00000162282
resolver
enst
ENSRNOT00055054251
resolver
enst
ENSRNOT00065053456
resolver
genesymbol
Ch25h
resolver
uniprot_entry
CH25H_RAT
resolver
amino_acid_sequence
MACHNVSELQDLGCSNQLLLQPLWDSIRTGEASARSPFFPVIFSIFTYLGFCLPFVVLDVLCPWVPILRRYKIHPDFSPSVRQLLPCLGLTLYQHLVFVFPVTLMHWARSPALLPREAPELSQLLSHVLICLLLFDTEIFAWHLLHHKVPWLYRTFHKVHHQNSSSFALATQYMSVWELLSLTFFDVLNVAMLQCHPLTILVFHVVNIWLSVEDHSGYDFPWSTHRLVPFGWYGGVAHHDLHHSQFNCNFAPYFTHWDKMLGTLRCAPHSKRLCAGSESCLDSGEQCTVHLNQKKKQT
uniprot
proteins
ec_number
1.14.99.38
uniprot
proteins
function
FUNCTION: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:11207193, PubMed:11967195). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages plays a role in Leydig cell differentiation (PubMed:11207193, PubMed:11967195). Required to restrain inflammation in macrophages: production of 25-hydroxycholesterol protects macrophages from cholesterol overload, thereby preventing mitochondrial DNA release and subsequent activation of the AIM2 inflammasome (By similarity). Interferon-stimulated gene which has broad antiviral activities against a wide range of enveloped viruses (By similarity). {ECO:0000250|UniProtKB:O95992, ECO:0000250|UniProtKB:Q9Z0F5, ECO:0000269|PubMed:11207193, ECO:0000269|PubMed:11967195}.; FUNCTION: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (By similarity). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (By similarity). May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. As an interferon-stimulated gene, has broad antiviral activities against a wide range of enveloped viruses. Its product, 25-hydroxycholesterol, activates the ER-localized enzyme ACAT to induce internalization of accessible cholesterol on the plasma membrane and restricts virus-host membranes fusion which inhibits virus replication (By similarity). In testis, production of 25-hydroxycholesterol by macrophages plays a role in Leydig cell differentiation (PubMed:11207193, PubMed:11967195). {ECO:0000250|UniProtKB:O95992, ECO:0000250|UniProtKB:Q9Z0F5, ECO:0000269|PubMed:11207193, ECO:0000269|PubMed:11967195}.
uniprot
proteins
mass_dalton
34414
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9Z0F5}.
uniprot
proteins
protein_family
Sterol desaturase family
uniprot
proteins
pubmed
11207193
uniprot
proteins
pubmed
11967195
uniprot
proteins
pubmed
12390873
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
298
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z0F5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Z0F5}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 124..144; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins