CAMK1D
entrez
57118
canonical
uniprot
Q8IU85
canonical
ensembl
ENSG00000183049
resolver
ensp
ENSP00000368122
resolver
ensp
ENSP00000478874
resolver
genesymbol
CAMK1D
resolver
genesymbol_syn
CAMKID
resolver
hgnc
HGNC:19341
resolver
uniprot
B0YIY0
resolver
uniprot
Q5SQQ7
resolver
uniprot
Q9HD31
resolver
uniprot_entry
KCC1D_HUMAN
resolver
uniprot_entry
Q5SQQ7_HUMAN
resolver
uniprot_sec
B0YIY0
resolver
uniprot_sec
Q9HD31
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-180 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-180 results in several fold increase in total activity. Unlike CaMK4, may be unable to exhibit autonomous activity after Ca(2+)/calmodulin activation. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:12935886}.
uniprot
proteins
amino_acid_sequence
MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSSSGVSGVGAERRPRPTTVTAVHSGSK
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691, ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}.
uniprot
proteins
mass_dalton
42914
uniprot
proteins
mutagenesis
MUTAGEN 52; /note="K->A: Catalytically inactive form."; /evidence="ECO:0000269|PubMed:16324104"; MUTAGEN 180; /note="T->A: Loss of ionomycin-induced activation."; /evidence="ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:16324104
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11050006
uniprot
proteins
pubmed
12935886
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15840691
uniprot
proteins
pubmed
16324104
uniprot
proteins
pubmed
17056143
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18817731
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25218447
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Predominantly cytoplasmic. Nuclear localization increases upon activation by KCl treatment in hippocampal neurons.
uniprot
proteins