EMR2
entrez
30817
canonical
uniprot
Q9UHX3
canonical
ensembl
ENSG00000127507
resolver
ensp
ENSP00000319883
resolver
ensp
ENSP00000376689
resolver
ensp
ENSP00000376692
resolver
ensp
ENSP00000469277
resolver
ensp
ENSP00000470725
resolver
ensp
ENSP00000471297
resolver
ensp
ENSP00000472280
resolver
ensp
ENSP00000472735
resolver
ensp
ENSP00000574445
resolver
ensp
ENSP00000574447
resolver
ensp
ENSP00000574448
resolver
ensp
ENSP00000574449
resolver
enst
ENST00000392962
resolver
genesymbol
ADGRE2
resolver
genesymbol
EMR2
resolver
genesymbol_syn
EMR2
resolver
hgnc
HGNC:3337
resolver
uniprot
A0ACM8QGC0
resolver
uniprot
A0JNV7
resolver
uniprot
B4DQ96
resolver
uniprot
B4DWB8
resolver
uniprot
E7ESD7
resolver
uniprot
E9PBR1
resolver
uniprot
E9PEL6
resolver
uniprot
E9PEL8
resolver
uniprot
E9PFQ5
resolver
uniprot
E9PG91
resolver
uniprot
Q8NG96
resolver
uniprot
Q9Y4B1
resolver
uniprot_entry
A0ACM8QGC0_HUMAN
resolver
uniprot_entry
A0JNV7_HUMAN
resolver
uniprot_entry
AGRE2_HUMAN
resolver
uniprot_entry
B4DWB8_HUMAN
resolver
uniprot_sec
B4DQ96
resolver
uniprot_sec
E7ESD7
resolver
uniprot_sec
E9PBR1
resolver
uniprot_sec
E9PEL6
resolver
uniprot_sec
E9PEL8
resolver
uniprot_sec
E9PFQ5
resolver
uniprot_sec
E9PG91
resolver
uniprot_sec
Q8NG96
resolver
uniprot_sec
Q9Y4B1
resolver
amino_acid_sequence
MGGRVFLVFLAFCVWLTLPGAETQDSRGCARWCPQDSSCVNATACRCNPGFSSFSEIITTPMETCDDINECATLSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKLKPEDPKLCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDYKPGLANNTIQSILQALDELLEAPGDLETLPRLQQHCVASHLLDGLEDVLRGLSKNLSNGLLNFSYPAGTELSLEVQKQVDRSVTLRQNQAVMQLDWNQAQKSGDPGPSVVGLVSIPGMGKLLAEAPLVLEPEKQMLLHETHQGLLQDGSPILLSDVISAFLSNNDTQNLSSPVTFTFSHRSVIPRQKVLCVFWEHGQNGCGHWATTGCSTIGTRDTSTICRCTHLSSFAVLMAHYDVQEEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLSLCLFLAHLLFLVAIDQTGHKVLCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVVNYSSINRFMKKLMFPVGYGVPAVTVAISAASRPHLYGTPSRCWLQPEKGFIWGFLGPVCAIFSVNLVLFLVTLWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWCLGILQVGPAARVMAYLFTIINSLQGVFIFLVYCLLSQQVREQYGKWSKGIRKLKTESEMHTLSSSAKADTSKPSTVN
uniprot
proteins
disease_involvement
DISEASE: Vibratory urticaria (VBU) [MIM:125630]: An autosomal dominant disorder characterized by localized hives and systemic manifestations in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum. {ECO:0000269|PubMed:26841242}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Probably signals through G proteins. Is a regulator of mast cell degranulation (PubMed:26841242). {ECO:0000269|PubMed:12829604, ECO:0000269|PubMed:17928360, ECO:0000269|PubMed:22310662, ECO:0000269|PubMed:22575658, ECO:0000269|PubMed:26841242}.
uniprot
proteins
mass_dalton
90472
uniprot
proteins
mutagenesis
MUTAGEN 518; /note="S->A: Abolishes cleavage."; /evidence="ECO:0000269|PubMed:12860403
uniprot
proteins
post_translational_modification
PTM: Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit. {ECO:0000269|PubMed:12860403}.
uniprot
proteins
protein_family
Adhesion G protein-coupled receptor (ADGR) subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
10903844
uniprot
proteins
pubmed
11994511
uniprot
proteins
pubmed
12829604
uniprot
proteins
pubmed
12860403
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15150276
uniprot
proteins
pubmed
17449467
uniprot
proteins
pubmed
17928360
uniprot
proteins
pubmed
22310662
uniprot
proteins
pubmed
22575658
uniprot
proteins
pubmed
25713288
uniprot
proteins
pubmed
26841242
uniprot
proteins
sequence_length
823
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22310662, ECO:0000269|PubMed:26841242}; Multi-pass membrane protein. Cell projection, ruffle membrane {ECO:0000269|PubMed:17928360}; Multi-pass membrane protein. Note=Localized at the leading edge of migrating cells. {ECO:0000269|PubMed:17928360}.
uniprot
proteins
transmembrane_region
TRANSMEM 541..561; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 570..590; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 606..626; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 645..665; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 684..704; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 736..756; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 761..781; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins