Jup
entrez
81679
canonical
uniprot
Q6P0K8
canonical
ensembl
ENSRNOG00000015380
resolver
ensembl
ENSRNOG00055033360
resolver
ensembl
ENSRNOG00060025951
resolver
ensembl
ENSRNOG00065032933
resolver
ensp
ENSRNOP00000043950
resolver
ensp
ENSRNOP00055047567
resolver
ensp
ENSRNOP00060037327
resolver
ensp
ENSRNOP00065046646
resolver
enst
ENSRNOT00000040845
resolver
enst
ENSRNOT00055057681
resolver
enst
ENSRNOT00060044995
resolver
enst
ENSRNOT00065056667
resolver
genesymbol
Jup
resolver
genesymbol_syn
Pg
resolver
uniprot_entry
PLAK_RAT
resolver
amino_acid_sequence
MEVMNLIEQPIKVTEWQQTYTYDSGIHSGVNTCVPSVSSKGLLDEDDTCGRQYTLKKTTTYTQGVPQSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQTTNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQGLVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLENVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYADDMDATYRPMYSSDVPLDPLDMHMDMDGDYPMDTYSDGLRPPYPAADHMLA
uniprot
proteins
function
FUNCTION: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q02257}.
uniprot
proteins
mass_dalton
81801
uniprot
proteins
post_translational_modification
PTM: Cleaved by CASP3 in response to apoptosis. {ECO:0000250|UniProtKB:P14923}.; PTM: May be phosphorylated by FER. {ECO:0000250}.
uniprot
proteins
protein_family
Beta-catenin family
uniprot
proteins
pubmed
11125272
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21617128
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
26858265
uniprot
proteins
sequence_length
745
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000250|UniProtKB:P14923}. Cell junction, desmosome {ECO:0000269|PubMed:11125272, ECO:0000269|PubMed:21617128, ECO:0000269|PubMed:26858265}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P14923}. Cell membrane {ECO:0000250|UniProtKB:P14923}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14923}. Cytoplasm {ECO:0000250|UniProtKB:Q9PVF7}. Cell junction {ECO:0000250|UniProtKB:Q9PVF7}. Nucleus {ECO:0000250|UniProtKB:Q9PVF7}. Cell projection, axon {ECO:0000250|UniProtKB:Q02257}. Note=Cytoplasmic in a soluble and membrane-associated form. Colocalizes with DSG4 at desmosomes (By similarity). {ECO:0000250|UniProtKB:P14923}.
uniprot
proteins