RANBP9
entrez
10048
canonical
uniprot
Q96S59
canonical
ensembl
ENSG00000010017
resolver
ensp
ENSP00000011619
resolver
genesymbol
RANBP9
resolver
genesymbol_syn
RANBPM
resolver
hgnc
HGNC:13727
resolver
uniprot
A0PJA2
resolver
uniprot
B2R8E1
resolver
uniprot
O94764
resolver
uniprot
Q6P3T7
resolver
uniprot
Q7LBR2
resolver
uniprot
Q7Z7F9
resolver
uniprot_entry
RANB9_HUMAN
resolver
uniprot_sec
A0PJA2
resolver
uniprot_sec
B2R8E1
resolver
uniprot_sec
O94764
resolver
uniprot_sec
Q6P3T7
resolver
uniprot_sec
Q7LBR2
resolver
uniprot_sec
Q7Z7F9
resolver
amino_acid_sequence
MSGQPPPPPPQQQQQQQQLSPPPPAALAPVSGVVLPAPPAVSAGSSPAGSPGGGAGGEGLGAAAAALLLHPPPPPPPATAAPPPPPPPPPPPASAAAPASGPPAPPGLAAGPGPAGGAPTPALVAGSSAAAPFPHGDSALNEQEKELQRRLKRLYPAVDEQETPLPRSWSPKDKFSYIGLSQNNLRVHYKGHGKTPKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINNTCFYTKNGHSLGIAFTDLPPNLYPTVGLQTPGEVVDANFGQHPFVFDIEDYMREWRTKIQAQIDRFPIGDREGEWQTMIQKMVSSYLVHHGYCATAEAFARSTDQTVLEELASIKNRQRIQKLVLAGRMGEAIETTQQLYPSLLERNPNLLFTLKVRQFIEMVNGTDSEVRCLGGRSPKSQDSYPVSPRPFSSPSMSPSHGMNIHNLASGKGSTAHFSGFESCSNGVISNKAHQSYCHSNKHQSSNLNVPELNSINMSRSQQVNNFTSNDVDMETDHYSNGVGETSSNGFLNGSSKHDHEMEDCDTEMEVDSSQLRRQLCGGSQAAIERMIHFGRELQAMSEQLRRDCGKNTANKKMLKDAFSLLAYSDPWNSPVGNQLDPIQREPVCSALNSAILETHNLPKQPPLALAMGQATQCLGLMARSGIGSCAFATVEDYLH
uniprot
proteins
function
FUNCTION: May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}.
uniprot
proteins
mass_dalton
77847
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in response to stress. Can be phosphorylated by the cleaved p110 form of CDC2L1 (p110C). {ECO:0000269|PubMed:14511641, ECO:0000269|PubMed:14722085}.; PTM: Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system. Can be deubiquitinated by USP11. {ECO:0000269|PubMed:12084015}.
uniprot
proteins
protein_family
RANBP9/10 family
uniprot
proteins
pubmed
11470507
uniprot
proteins
pubmed
12084015
uniprot
proteins
pubmed
12147692
uniprot
proteins
pubmed
12220523
uniprot
proteins
pubmed
12361945
uniprot
proteins
pubmed
12421467
uniprot
proteins
pubmed
12559565
uniprot
proteins
pubmed
12684061
uniprot
proteins
pubmed
14500717
uniprot
proteins
pubmed
14511641
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14684163
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14722085
uniprot
proteins
pubmed
15381419
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15558019
uniprot
proteins
pubmed
17467196
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18222118
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18710924
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20580816
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24143168
uniprot
proteins
pubmed
27622290
uniprot
proteins
pubmed
29911972
uniprot
proteins
pubmed
9817760
uniprot
proteins
sequence_length
729
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11470507, ECO:0000269|PubMed:14511641, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:24143168}. Nucleus {ECO:0000269|PubMed:11470507, ECO:0000269|PubMed:14511641, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:18222118}. Cell membrane {ECO:0000269|PubMed:14722085}; Peripheral membrane protein {ECO:0000269|PubMed:14722085}. Note=The unphosphorylated form is predominantly cytoplasmic. A phosphorylated form is associated with the plasma membrane. {ECO:0000269|PubMed:14722085}.
uniprot
proteins