PRCD
entrez
768206
canonical
uniprot
Q00LT1
canonical
ensembl
ENSG00000214140
resolver
ensp
ENSP00000465932
resolver
ensp
ENSP00000467661
resolver
enst
ENST00000586148
resolver
enst
ENST00000592014
resolver
genesymbol
PRCD
resolver
hgnc
HGNC:32528
resolver
uniprot
B9EJD4
resolver
uniprot_entry
PRCD_HUMAN
resolver
uniprot_sec
B9EJD4
resolver
amino_acid_sequence
MCTTLFLLSTLAMLWRRRFANRVQPEPSDVDGAARGSSLDADPQSSGREKEPLK
uniprot
proteins
disease_involvement
DISEASE: Retinitis pigmentosa 36 (RP36) [MIM:610599]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. {ECO:0000269|PubMed:16938425, ECO:0000269|PubMed:24992209, ECO:0000269|PubMed:27613864}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Involved in vision. {ECO:0000269|PubMed:16938425, ECO:0000269|PubMed:24992209}.
uniprot
proteins
mass_dalton
6007
uniprot
proteins
post_translational_modification
PTM: Palmitoylated at Cys-2 (PubMed:27613864). Palmitoylation is essential for protein stability and trafficking to the photoreceptor outer segment, but does not appear to be essential for membrane localization (PubMed:27613864). Probably palmitoylated by ZDHHC3 (PubMed:27613864). {ECO:0000269|PubMed:27613864}.; PTM: Phosphorylated. {ECO:0000250|UniProtKB:E1B7R9}.
uniprot
proteins
protein_family
PRCD family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16938425
uniprot
proteins
pubmed
24992209
uniprot
proteins
pubmed
27613864
uniprot
proteins
sequence_length
54
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:27613864}. Membrane {ECO:0000269|PubMed:27613864}; Lipid-anchor {ECO:0000269|PubMed:27613864}; Cytoplasmic side {ECO:0000250|UniProtKB:Q00LT2}. Endoplasmic reticulum {ECO:0000269|PubMed:24992209}. Golgi apparatus {ECO:0000269|PubMed:24992209}. Note=Localizes to photoreceptor disk membranes in the photoreceptor outer segment (PubMed:27613864). The secretion in media described in PubMed:24992209 is probably an experimental artifact (PubMed:24992209). {ECO:0000269|PubMed:24992209, ECO:0000269|PubMed:27613864}.
uniprot
proteins