RTP4
entrez
64108
canonical
uniprot
Q96DX8
canonical
ensembl
ENSG00000136514
resolver
ensembl
ENSG00000291555
resolver
ensp
ENSP00000259030
resolver
ensp
ENSP00000517060
resolver
enst
ENST00000259030
resolver
enst
ENST00000707986
resolver
genesymbol
RTP4
resolver
genesymbol_syn
IFRG28
resolver
genesymbol_syn
Z3CXXC4
resolver
hgnc
HGNC:23992
resolver
uniprot
Q9H4F3
resolver
uniprot_entry
RTP4_HUMAN
resolver
uniprot_sec
Q9H4F3
resolver
amino_acid_sequence
MVVDFWTWEQTFQELIQEAKPRATWTLKLDGNLQLDCLAQGWKQYQQRAFGWFRCSSCQRSWASAQVQILCHTYWEHWTSQGQVRMRLFGQRCQKCSWSQYEMPEFSSDSTMRILSNLVQHILKKYYGNGTRKSPEMPVILEVSLEGSHDTANCEACTLGICGQGLKSCMTKPSKSLLPHLKTGNSSPGIGAVYLANQAKNQSAEAKEAKGSGYEKLGPSRDPDPLNICVFILLLVFIVVKCFTSE
uniprot
proteins
function
FUNCTION: Chaperone protein that facilitates the trafficking and functional cell surface expression of some G protein-coupled receptors (GPCRs) (PubMed:18836069). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity). In addition, acts as a potent IFN-inducible suppressor of pathogens including lyssavirus rabies, influenza A or yellow fever virus (PubMed:33113352). Mechanistically, associates with the viral replicase, binds viral RNA, and thereby suppresses viral genome amplification that replicates at the endoplasmic reticulum (By similarity). In addition, restores antiviral signaling by interacting with and sequestering influenza A virus protein NS1 (PubMed:39798334). {ECO:0000250|UniProtKB:Q9ER80, ECO:0000269|PubMed:16720576, ECO:0000269|PubMed:18836069, ECO:0000269|PubMed:33113352, ECO:0000269|PubMed:39798334}.
uniprot
proteins
mass_dalton
27863
uniprot
proteins
mutagenesis
MUTAGEN 55; /note="C->A: Loss of interaction with influenza virus NS1."; /evidence="ECO:0000269|PubMed:39798334"; MUTAGEN 93; /note="C->A: Loss of interaction with influenza virus NS1."; /evidence="ECO:0000269|PubMed:39798334"; MUTAGEN 149; /note="H->A: Almost complete loss of influenza NA viral RNA binding and loss of interaction with influenza virus NS1."; /evidence="ECO:0000269|PubMed:39798334"; MUTAGEN 154; /note="C->A: Complete loss of influenza NA viral RNA binding and loss of interaction with influenza virus NS1."; /evidence="ECO:0000269|PubMed:39798334
uniprot
proteins
protein_family
TMEM7 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15550249
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16720576
uniprot
proteins
pubmed
18836069
uniprot
proteins
pubmed
33113352
uniprot
proteins
pubmed
39798334
uniprot
proteins
sequence_length
246
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:39798334}.
uniprot
proteins
transmembrane_region
TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins