TRIM31
entrez
11074
canonical
uniprot
Q9BZY9
canonical
ensembl
ENSG00000137397
resolver
ensembl
ENSG00000204616
resolver
ensembl
ENSG00000223531
resolver
ensembl
ENSG00000224168
resolver
ensembl
ENSG00000225130
resolver
ensembl
ENSG00000233573
resolver
ensp
ENSP00000350182
resolver
ensp
ENSP00000365924
resolver
ensp
ENSP00000390551
resolver
ensp
ENSP00000543858
resolver
enst
ENST00000357569
resolver
enst
ENST00000433864
resolver
genesymbol
TRIM31
resolver
genesymbol_syn
C6orf13
resolver
genesymbol_syn
RNF
resolver
hgnc
HGNC:16289
resolver
uniprot
A0A1U9X8Q7
resolver
uniprot
A6NLX6
resolver
uniprot
A9R9Q4
resolver
uniprot
Q2L6J1
resolver
uniprot
Q53H52
resolver
uniprot
Q5RI37
resolver
uniprot
Q5SRJ7
resolver
uniprot
Q5SRJ8
resolver
uniprot
Q5SS28
resolver
uniprot
Q96AK4
resolver
uniprot
Q96AP8
resolver
uniprot
Q99579
resolver
uniprot
Q9BZY8
resolver
uniprot_entry
Q2L6J1_HUMAN
resolver
uniprot_entry
TRI31_HUMAN
resolver
uniprot_sec
A0A1U9X8Q7
resolver
uniprot_sec
A6NLX6
resolver
uniprot_sec
A9R9Q4
resolver
uniprot_sec
Q53H52
resolver
uniprot_sec
Q5RI37
resolver
uniprot_sec
Q5SRJ7
resolver
uniprot_sec
Q5SRJ8
resolver
uniprot_sec
Q5SS28
resolver
uniprot_sec
Q96AK4
resolver
uniprot_sec
Q96AP8
resolver
uniprot_sec
Q99579
resolver
uniprot_sec
Q9BZY8
resolver
amino_acid_sequence
MASGQFVNKLQEEVICPICLDILQKPVTIDCGHNFCLKCITQIGETSCGFFKCPLCKTSVRKNAIRFNSLLRNLVEKIQALQASEVQSKRKEATCPRHQEMFHYFCEDDGKFLCFVCRESKDHKSHNVSLIEEAAQNYQGQIQEQIQVLQQKEKETVQVKAQGVHRVDVFTDQVEHEKQRILTEFELLHQVLEEEKNFLLSRIYWLGHEGTEAGKHYVASTEPQLNDLKKLVDSLKTKQNMPPRQLLEDIKVVLCRSEEFQFLNPTPVPLELEKKLSEAKSRHDSITGSLKKFKDQLQADRKKDENRFFKSMNKNDMKSWGLLQKNNHKMNKTSEPGSSSAGGRTTSGPPNHHSSAPSHSLFRASSAGKVTFPVCLLASYDEISGQGASSQDTKTFDVALSEELHAALSEWLTAIRAWFCEVPSS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates (PubMed:18773414, PubMed:27929086, PubMed:27992402). Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria (PubMed:27992402). Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation (PubMed:27929086). Regulator of Src-induced anchorage independent cell growth (By similarity). {ECO:0000250|UniProtKB:Q8R0K2, ECO:0000269|PubMed:18773414, ECO:0000269|PubMed:27929086, ECO:0000269|PubMed:27992402}.
uniprot
proteins
mass_dalton
48244
uniprot
proteins
mutagenesis
MUTAGEN 16; /note="C->A: Abolished E3 ubiquitin-protein ligase activity and ability to ubiquitinate NLRP3; when associated with A-31."; /evidence="ECO:0000269|PubMed:27929086"; MUTAGEN 31; /note="C->A: Abolished E3 ubiquitin-protein ligase activity and ability to ubiquitinate NLRP3; when associated with A-16."; /evidence="ECO:0000269|PubMed:27929086"; MUTAGEN 53..56; /note="CPLC->APLA: Abolished E3 ubiquitin-protein ligase activity and ability to ubiquitinate MAVS."; /evidence="ECO:0000269|PubMed:27929086
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:18773414, ECO:0000269|PubMed:27929086}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated (in vitro). {ECO:0000269|PubMed:18773414}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18773414
uniprot
proteins
pubmed
27929086
uniprot
proteins
pubmed
27992402
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18773414}. Mitochondrion {ECO:0000269|PubMed:18773414, ECO:0000269|PubMed:27992402}. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria (PubMed:18773414). Recruited t omitochondria after viral infection (PubMed:27992402). {ECO:0000269|PubMed:18773414, ECO:0000269|PubMed:27992402}.
uniprot
proteins