Adrb3
entrez
11556
canonical
uniprot
P25962
canonical
ensembl
ENSMUSG00000031489
resolver
ensp
ENSMUSP00000080162
resolver
ensp
ENSMUSP00000113006
resolver
ensp
ENSMUSP00000246257
resolver
genesymbol
Adrb3
resolver
genesymbol_syn
Adrb3r
resolver
genesymbol_syn
B3bar
resolver
uniprot
A2RS74
resolver
uniprot
Q3UP63
resolver
uniprot
Q9QZ98
resolver
uniprot_entry
ADRB3_MOUSE
resolver
uniprot_entry
Q3UP63_MOUSE
resolver
uniprot_sec
A2RS74
resolver
uniprot_sec
Q9QZ98
resolver
amino_acid_sequence
MAPWPHRNGSLALWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVIIAIARTPRLQTITNVFVTSLAAADLVVGLLVMPPGATLALTGHWPLGETGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSAAVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRHLLRRELGRFSPEESPPSPSRSPSPATGGTPAAPDGVPPCGRRPARLLPLREHRALRTLGLIMGIFSLCWLPFFLANVLRALAGPSLVPSGVFIALNWLGYANSAFNPVIYCRSPDFRDAFRRLLCSYGGRGPEEPRAVTFPASPVEARQSPPLNRFDGYEGARPFPT
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent pathway, respectively (PubMed:1718744). The rank order of potency for physiological agonists is norepinephrine > epinephrine (By similarity). Involved in the regulation of thermogenesis and lipolysis in brown and white adipose tissue, after coupling to G(s) proteins and stimulation of the cAMP-PKA axis (PubMed:10207024, PubMed:1718744). Also activates lipolytic process by coupling to G(i) proteins and consequent initiation of the ERK1/2 MAP kinase cascade (PubMed:10207024, PubMed:17032647). Participates in relaxation of the blood vessels and the urinary bladder. Also mediates negative inotropic effects in cardiomyocytes through activation of an NO synthase pathway and subsequent increase in cGMP levels, possibly involving G(i/o) protein-mediated coupling (By similarity). {ECO:0000250|UniProtKB:P13945, ECO:0000269|PubMed:10207024, ECO:0000269|PubMed:17032647, ECO:0000269|PubMed:1718744}.
uniprot
proteins
mass_dalton
43006
uniprot
proteins
protein_family
ADRB3 sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10207024
uniprot
proteins
pubmed
10455305
uniprot
proteins
pubmed
1336117
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17032647
uniprot
proteins
pubmed
1718744
uniprot
proteins
pubmed
8389293
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:O02662}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..57; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O02662"; TRANSMEM 71..97; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O02662"; TRANSMEM 106..130; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O02662"; TRANSMEM 151..171; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O02662"; TRANSMEM 200..220; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O02662"; TRANSMEM 292..315; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O02662"; TRANSMEM 319..341; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:O02662
uniprot
proteins