Themis
entrez
210757
canonical
uniprot
Q8BGW0
canonical
ensembl
ENSMUSG00000049109
resolver
ensp
ENSMUSP00000060129
resolver
ensp
ENSMUSP00000101155
resolver
genesymbol
Themis
resolver
uniprot
Q059Y0
resolver
uniprot
Q3TEM0
resolver
uniprot
Q3UU76
resolver
uniprot
Q8BGP0
resolver
uniprot
Q8C9S6
resolver
uniprot_entry
THMS1_MOUSE
resolver
uniprot_sec
Q059Y0
resolver
uniprot_sec
Q3TEM0
resolver
uniprot_sec
Q3UU76
resolver
uniprot_sec
Q8BGP0
resolver
uniprot_sec
Q8C9S6
resolver
amino_acid_sequence
MALSLEEFVYSLDLRTLPRVLEIQSGIYFEGSVYEMFGNECCLSTGEVIKITGLKIKKMMAEICEGAIGGCESQKPFELPMNFPGLFKVMADKTPYLSIEEITRTVNIGPSRLGHPCFYHLKDIKLENLIIKQGEPIRFNSVEEINGETLVNCGVVRNHQSHSFTLPLSQEGEFYECEDEHIYTLKEIVEWKIPKNRTRTVKLTDFSNKWDSTNPFPEDFYGTLILKPVYEIQGVLKFQKDIVRILPSLDVEVKDITDSYDANWFLQLLSTDDLFEMTSKEFPVVAEVVEISQGNHLPQSILQREKTIVIHKKYQASRILASEIRSNFPKRHFLIPISYKGKFKRRPREFPTAYDLQIAKSRKETLHVVATKAFHTLHKELSPVSVGDQFLVHHSETTEVVFEGTRKVNVLTCEKVLNKTREDAQLPLYMEGGFVEVIHDKKQYQISELCTQFCWPFNVKVAVRDLSIKDDILAATPGLQLEEDITDSYLLISDFANPEECWEIPMSRLNMTVRLVNGSSLPADAGLLQVRSFVEEITEEQYYMMRRYESSLSHPPPRPPKHPSAEEMKLTLLSLAEERTINLPKSLKSHHVDRPKKLPSDESGQDSRAPVGFQNDVADVERQKSKHGPLQPQAPL
uniprot
proteins
function
FUNCTION: Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. {ECO:0000269|PubMed:19597497, ECO:0000269|PubMed:19597498, ECO:0000269|PubMed:19597499, ECO:0000269|PubMed:19620281, ECO:0000269|PubMed:19805304}.
uniprot
proteins
mass_dalton
72780
uniprot
proteins
mutagenesis
MUTAGEN 512; /note="T->P: Decreased levels of protein expression in thymocytes. Reduced numbers of CD4 and CD8 single-positive thymocytes as well as reduced numbers of peripheral CD4 and CD8 T-cells."; /evidence="ECO:0000269|PubMed:19620281
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr residues quickly after TCR stimulation. {ECO:0000269|PubMed:19597498, ECO:0000269|PubMed:19597499}.
uniprot
proteins
protein_family
Themis family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19597497
uniprot
proteins
pubmed
19597498
uniprot
proteins
pubmed
19597499
uniprot
proteins
pubmed
19620281
uniprot
proteins
pubmed
19805304
uniprot
proteins
pubmed
22561606
uniprot
proteins
sequence_length
636
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19597497, ECO:0000269|PubMed:19597498, ECO:0000269|PubMed:19620281}. Nucleus {ECO:0000269|PubMed:19597498, ECO:0000269|PubMed:19620281}.
uniprot
proteins