P2RY1
entrez
5028
canonical
uniprot
P47900
canonical
ensembl
ENSG00000169860
resolver
ensp
ENSP00000304767
resolver
enst
ENST00000305097
resolver
genesymbol
P2RY1
resolver
hgnc
HGNC:8539
resolver
uniprot_entry
P2RY1_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: ATP functions as antagonist and inhibits ADP-induced mobilization of Ca(2+) (PubMed:9038354). The P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P inhibit downstream signaling mediated by mobilization of Ca(2+) from intracellular stores, and platelet shape changes in response to extracellular ADP (PubMed:9442040). {ECO:0000269|PubMed:9038354, ECO:0000269|PubMed:9442040}.
uniprot
proteins
amino_acid_sequence
MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL
uniprot
proteins
function
FUNCTION: Receptor for extracellular adenine nucleotides such as ADP (PubMed:25822790, PubMed:9038354, PubMed:9442040). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040). {ECO:0000269|PubMed:25822790, ECO:0000269|PubMed:9038354, ECO:0000269|PubMed:9442040}.
uniprot
proteins
mass_dalton
42072
uniprot
proteins
mutagenesis
MUTAGEN 44; /note="L->A: Loss of ADP analog binding."; /evidence="ECO:0000269|PubMed:25822790"; MUTAGEN 110; /note="Y->F: Loss of ADP analog binding."; /evidence="ECO:0000269|PubMed:25822790"; MUTAGEN 203; /note="Y->A: Loss of ADP analog binding."; /evidence="ECO:0000269|PubMed:25822790"; MUTAGEN 205; /note="T->A: Loss of ADP analog binding."; /evidence="ECO:0000269|PubMed:25822790"; MUTAGEN 283; /note="N->A: Loss of ADP analog binding."; /evidence="ECO:0000269|PubMed:25822790"; MUTAGEN 306; /note="Y->F: Strongly decreased affinity for ADP analog."; /evidence="ECO:0000269|PubMed:25822790
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
25822790
uniprot
proteins
pubmed
8579591
uniprot
proteins
pubmed
8630005
uniprot
proteins
pubmed
8666290
uniprot
proteins
pubmed
9038354
uniprot
proteins
pubmed
9442040
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25822790}; Multi-pass membrane protein {ECO:0000269|PubMed:25822790}.
uniprot
proteins
transmembrane_region
TRANSMEM 52..74; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:25822790"; TRANSMEM 88..109; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:25822790"; TRANSMEM 126..147; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:25822790"; TRANSMEM 167..188; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:25822790"; TRANSMEM 215..237; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:25822790"; TRANSMEM 261..284; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:25822790"; TRANSMEM 304..325; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:25822790
uniprot
proteins