Acox1
entrez
50681
canonical
uniprot
P07872
canonical
ensembl
ENSRNOG00000008755
resolver
ensembl
ENSRNOG00055032083
resolver
ensembl
ENSRNOG00060026651
resolver
ensembl
ENSRNOG00065019270
resolver
ensp
ENSRNOP00000042132
resolver
ensp
ENSRNOP00000051538
resolver
ensp
ENSRNOP00000087983
resolver
enst
ENSRNOT00000108949
resolver
genesymbol
Acox1
resolver
genesymbol_syn
Acox
resolver
uniprot
A0A8I6A8D0
resolver
uniprot
P11354
resolver
uniprot_entry
A0A8I6A8D0_RAT
resolver
uniprot_entry
ACOX1_RAT
resolver
uniprot_sec
P11354
resolver
amino_acid_sequence
MNPDLRKERASATFNPELITHILDGSPENTRRRREIENLILNDPDFQHEDYNFLTRSQRYEVAVKKSATMVKKMREYGISDPEEIMWFKKLYLANFVEPVGLNYSMFIPTLLNQGTTAQQEKWMRPSQELQIIGTYAQTEMGHGTHLRGLETTATYDPKTQEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITQGECYGLHAFVVPIREIGTHKPLPGITVGDIGPKFGYEEMDNGYLKMDNYRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGNAAQSLSKACTIAIRYSAVRRQSEIKQSEPEPQILDFQTQQYKLFPLLATAYAFHFVGRYMKETYLRINESIGQGDLSELPELHALTAGLKAFTTWTANAGIEECRMACGGHGYSHSSGIPNIYVTFTPACTFEGENTVMMLQTARFLMKIYDQVRSGKLVGGMVSYLNDLPSQRIQPQQVAVWPTMVDINSLEGLTEAYKLRAARLVEIAAKNLQTHVSHRKSKEVAWNLTSVDLVRASEAHCHYVVVKVFSDKLPKIQDKAVQAVLRNLCLLYSLYGISQKGGDFLEGSIITGAQLSQVNARILELLTLIRPNAVALVDAFDFKDMTLGSVLGRYDGNVYENLFEWAKKSPLNKTEVHESYHKHLKPLQSKL
uniprot
proteins
ec_number
1.3.3.6
uniprot
proteins
function
FUNCTION: Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids. Catalyzes the desaturation of fatty acyl-CoAs that have a saturated bond between C2 and C3 (2,3-saturated acyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs), and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)). May play a role in peroxisomal beta-oxidation step in polyunsaturated fatty acids (PUFAs) biosynthesis. Possibly regulates systemic levels of docosahexaenoic acid (DHA, C22:6n-3) through a process involving endoplasmic reticulum desaturation and elongation of alpha-linolenic acid (ALA, C18:3n-3) to form tetracosahexaenoic acid (THA, C24:6n-3), which is then beta-oxidized to DHA in peroxisomes (By similarity). Involved in VLCFA-dependent hepatic-to-adipose tissue inter-organ signaling in response to diet. Through hepatic beta-oxidation of THA, may regulate THA systemic levels and THA-dependent activation of FFAR4 signaling in adipocytes, limiting adipose tissue thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q15067, ECO:0000250|UniProtKB:Q9R0H0, ECO:0000269|PubMed:1400324, ECO:0000269|PubMed:16672280, ECO:0000269|PubMed:7462191, ECO:0000269|PubMed:7503725}.; FUNCTION: [Isoform 1]: Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro. {ECO:0000269|PubMed:7503725}.; FUNCTION: [Isoform 2]: Is active against a much broader range of substrates and shows activity towards long-chain acyl-CoAs. {ECO:0000269|PubMed:7503725}.
uniprot
proteins
mass_dalton
74679
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation.
uniprot
proteins
protein_family
Acyl-CoA oxidase family
uniprot
proteins
pubmed
11872165
uniprot
proteins
pubmed
1400324
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16672280
uniprot
proteins
pubmed
3036800
uniprot
proteins
pubmed
3036801
uniprot
proteins
pubmed
32169171
uniprot
proteins
pubmed
7462191
uniprot
proteins
pubmed
7503725
uniprot
proteins
sequence_length
661
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:11872165}.
uniprot
proteins