SFTPA1
entrez
653509
canonical
uniprot
Q8IWL2
canonical
ensembl
ENSG00000122852
resolver
ensp
ENSP00000381633
resolver
ensp
ENSP00000397082
resolver
ensp
ENSP00000411102
resolver
ensp
ENSP00000565579
resolver
ensp
ENSP00000565583
resolver
ensp
ENSP00000565590
resolver
ensp
ENSP00000718687
resolver
genesymbol
SFTPA1
resolver
genesymbol_syn
COLEC4
resolver
genesymbol_syn
PSAP
resolver
genesymbol_syn
SFTP1
resolver
genesymbol_syn
SFTPA
resolver
genesymbol_syn
SFTPA1B
resolver
hgnc
HGNC:10798
resolver
uniprot
A8K3T8
resolver
uniprot
B4DNP6
resolver
uniprot
B7ZW50
resolver
uniprot
E3VLD8
resolver
uniprot
E3VLD9
resolver
uniprot
E3VLE0
resolver
uniprot
E3VLE1
resolver
uniprot
G5E9J3
resolver
uniprot
K4N2H0
resolver
uniprot
P07714
resolver
uniprot
Q14DV4
resolver
uniprot
Q5RIR5
resolver
uniprot
Q5RIR7
resolver
uniprot
Q6PIT0
resolver
uniprot
Q8TC19
resolver
uniprot_entry
B4DNP6_HUMAN
resolver
uniprot_entry
K4N2H0_HUMAN
resolver
uniprot_entry
SFTA1_HUMAN
resolver
uniprot_sec
A8K3T8
resolver
uniprot_sec
B7ZW50
resolver
uniprot_sec
E3VLD8
resolver
uniprot_sec
E3VLD9
resolver
uniprot_sec
E3VLE0
resolver
uniprot_sec
E3VLE1
resolver
uniprot_sec
G5E9J3
resolver
uniprot_sec
P07714
resolver
uniprot_sec
Q14DV4
resolver
uniprot_sec
Q5RIR5
resolver
uniprot_sec
Q5RIR7
resolver
uniprot_sec
Q6PIT0
resolver
uniprot_sec
Q8TC19
resolver
amino_acid_sequence
MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF
uniprot
proteins
disease_involvement
DISEASE: Interstitial lung disease 1 (ILD1) [MIM:619611]: A form of interstitial lung disease, a heterogeneous group of diseases affecting the distal part of the lung and characterized by a progressive remodeling of the alveolar interstitium. The disease spectrum ranges from idiopathic interstitial pneumonia or pneumonitis to idiopathic pulmonary fibrosis, that is associated with an increased risk of developing lung cancer. Clinical features of interstitial lung disease include dyspnea, clubbing of the fingers, and restrictive lung capacity. ILD1 inheritance can be autosomal dominant with incomplete penetrance, and autosomal recessive. {ECO:0000269|PubMed:26792177, ECO:0000269|PubMed:30854216, ECO:0000269|PubMed:31601679, ECO:0000269|PubMed:32855221}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Respiratory distress syndrome in premature infants (RDS) [MIM:267450]: A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. {ECO:0000269|PubMed:10762543}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry. The association between SFTPA1 alleles and respiratory distress syndrome in premature infants is dependent on a variation Ile to Thr at position 131 in SFTPB.
uniprot
proteins
function
FUNCTION: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity). {ECO:0000250|UniProtKB:P35242}.; FUNCTION: (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule (PubMed:17158455, PubMed:21203928). Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages (PubMed:21123169). {ECO:0000269|PubMed:17158455, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:21203928}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen (PubMed:15845487, PubMed:25139904). When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen (PubMed:25139904). {ECO:0000269|PubMed:15845487, ECO:0000269|PubMed:25139904}.
uniprot
proteins
mass_dalton
26242
uniprot
proteins
post_translational_modification
PTM: N-acetylated. {ECO:0000269|PubMed:3755136}.
uniprot
proteins
protein_family
SFTPA family
uniprot
proteins
pubmed
10762543
uniprot
proteins
pubmed
13680361
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15845487
uniprot
proteins
pubmed
17158455
uniprot
proteins
pubmed
19100526
uniprot
proteins
pubmed
20693318
uniprot
proteins
pubmed
21123169
uniprot
proteins
pubmed
21203928
uniprot
proteins
pubmed
25139904
uniprot
proteins
pubmed
2610270
uniprot
proteins
pubmed
26792177
uniprot
proteins
pubmed
2995821
uniprot
proteins
pubmed
30854216
uniprot
proteins
pubmed
31601679
uniprot
proteins
pubmed
32855221
uniprot
proteins
pubmed
3755136
uniprot
proteins
pubmed
7977768
uniprot
proteins
pubmed
9813381
uniprot
proteins
sequence_length
248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26792177, ECO:0000269|PubMed:32855221}. Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted, extracellular space, surface film {ECO:0000305}.
uniprot
proteins