Arhgap22
entrez
239027
canonical
uniprot
Q8BL80
canonical
ensembl
ENSMUSG00000063506
resolver
ensp
ENSMUSP00000107586
resolver
ensp
ENSMUSP00000107587
resolver
ensp
ENSMUSP00000305936
resolver
genesymbol
Arhgap22
resolver
uniprot
Q6QHH6
resolver
uniprot
Q8BVH4
resolver
uniprot
Q8CHY5
resolver
uniprot_entry
RHG22_MOUSE
resolver
uniprot_sec
Q6QHH6
resolver
uniprot_sec
Q8BVH4
resolver
uniprot_sec
Q8CHY5
resolver
amino_acid_sequence
MLPTASSKRRTFAARYFTRSKSLVMGEQSRSPGRPLVPHKLGPVLKAGWLRKQRSIMKNWQQRWFVLRGDQLFYYKDKDESKPQGFISLQGTQVTELLPDPEDPGKHLFEITPGGATEREKVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGRGIFGQRLEDTVHHERKFGPRLAPLLVEQCVDFIRERGLSEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDVHTVASLLKLYLRELPEPVIPFARYEDFLSCAQLLTKDEGEGTVELAKQVSNLPQANYNLLRYICKFLDEVQAHSDVNKMSVQNLATVFGPNILRPQIEDPVTIMEGTSLVQHLMTVLIRKHGQLFAATSLEEPASPHGTVEWGSEEVTRDHRGEPGSPGLPTHRTSSLDGPAAAVLSRTSPPRLGSQTGPAATSPGKKMHTLPVWKSSFRQQGSRSESPKGVNSSLEVPIISSGGNWLINGLSSLRSHRRASSGDRLKDTGSAQRLSTYDNVPPSSQFSSTASVASTSWSVASSSREASVSSCTACRASNSSACSSLHTEWALEPSPLPSSSEGHQSPDLGHSLDEPCVGSGSSEPNDPGSPTQAHVRRCRALQGQVAELRAELCQQRTEYKRSLKSIEEGSADLRKQMSRLEEELDQERKKYAMLEIKLRNSERAREDAERRNQLLQREMEEFFSTLGSLTTGTKGSRAPE
uniprot
proteins
function
FUNCTION: Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. {ECO:0000269|PubMed:14966113}.
uniprot
proteins
mass_dalton
77786
uniprot
proteins
mutagenesis
MUTAGEN 201; /note="R->A: Loss of function."; /evidence="ECO:0000269|PubMed:14966113
uniprot
proteins
pubmed
14966113
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
702
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14966113}. Nucleus {ECO:0000269|PubMed:14966113}. Note=Mainly cytoplasmic. Some fraction is nuclear.
uniprot
proteins