Lrrk1
entrez
233328
canonical
uniprot
Q3UHC2
canonical
ensembl
ENSMUSG00000015133
resolver
ensp
ENSMUSP00000015277
resolver
genesymbol
Lrrk1
resolver
genesymbol_syn
Kiaa1790
resolver
uniprot
Q3U476
resolver
uniprot
Q66JQ4
resolver
uniprot
Q6GQR9
resolver
uniprot
Q6NZF5
resolver
uniprot
Q6ZPI4
resolver
uniprot
Q8BKP3
resolver
uniprot
Q8BU93
resolver
uniprot
Q8BUY0
resolver
uniprot
Q8BVV2
resolver
uniprot
Q8R085
resolver
uniprot_entry
LRRK1_MOUSE
resolver
uniprot_sec
Q3U476
resolver
uniprot_sec
Q66JQ4
resolver
uniprot_sec
Q6GQR9
resolver
uniprot_sec
Q6NZF5
resolver
uniprot_sec
Q6ZPI4
resolver
uniprot_sec
Q8BKP3
resolver
uniprot_sec
Q8BU93
resolver
uniprot_sec
Q8BUY0
resolver
uniprot_sec
Q8BVV2
resolver
uniprot_sec
Q8R085
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation by PKC (By similarity). Binds both GTP and GDP; binding of GTP stimulates kinase activity (By similarity). Sterically autoinhibited in its dimeric state (By similarity). {ECO:0000250|UniProtKB:Q38SD2}.
uniprot
proteins
amino_acid_sequence
MAGTSQRPPSMYWCVGTEGLAVCPGPAMETHNGAEDMGSKLSLPGGSSTVQCPSMEEIHTAYKQRNLSRARDLLRGVCEESESSQEKGQLLSIAAAHGDLETVQFLLTEKRVELPTEPTDDNPAVVAAHFGHAEVVRELLESLPGPCTPQRLLNWMLALACQRGHLEVVKLLVLTHGADPENYAVRKNEFPVIVRLPLYAAIKAGNEDIAIFLLRHGAYFCSYILLDSPEPSKHLLRKYFIEASALPSSYPGKIALRVKWSHLKLPWVDLDWLLDISCQITELDLSANCLPSLPSIIPWGLINLKKLNLSNNQLGELPCVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNYLERLFEEENATNWIGLRKLQELDLADNRLTELPVQFMHSFKSLTSLNVSRNNLKSFPDPWSCPLKCCKASKNALESLPDKMAVFWKSHLRDADFSENSLKEVPLGLFQLDALMFLRLQGNQLLSLPPQEKWTCTQLKTLDLSRNQLGKNEDGLKTKRISLFTTRGRQRSGTETASMLEFPAFLSESLEVLCLNDNHLDAVPPSVCLLKNLSELYLGNNPGLRELPPELGQLGNLWQLDIEDLNISNVPAEVRKEGPKATLSFLRAQLRKAEKCKLMKMILVGPPRQGKSTLLEILQTGKAPQLAHSEATIRTTKWELQRPAGSKAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKNLEGQEGLRQLIFHVTCNMKDVGSTIGCQKLAGRLIPRSYISLQEAVLAEQQRRSLGDQVQYLTDRQLDQLVEQTPGNDIKDYEDLQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIQAEDLRMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHSMRHPMANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGSQRNRCSTFRVRRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGIKIICQSEMRDFSAMAFITDHVNSLIDQWFPALTATESDGTPLMEQYVPCPVCEASWAQHADPNERSESVQYFDMEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHTEGENSILGQGGSGTVIYQARYQGQPVAVKRFHIKKFKNSANAPADTMLRHLRAMDAMKNFSDFRQEASMLHALQHPCIVSLIGISIHPLCFALELAPLGSLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLSAKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIVKKLSKGIRPVLGQPEEVQFHRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYMLPCGKQSAFFSSQSQEYTVVFWDGKEESRNYTVVNTEKGLLEVQRMTCPGMKLSCQLKVQSSVWIATEDQKIYIYSLKGMCPLSVPQQALDTPAVVTCFLAVPVIKKNSFLVLAGLADGLVAVFPVARGTPKESCSYLCSHTANRSKFCIPDEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCTILDISRRLEPYAAPSMVTSLVCSSDCRGEEMVWCLDDKANCLVMYHSATYQLCARYFCGDPNPLRDTFSVQPSVLETPGSHKTTSKGPVEECIADVSIMYSEELGTQILTHQDSLTDYCSMSSYSSSPPHQDPRSPSSLPSSLTSYSSVPFSANYEDSDRLQEPSVTSDRTEHDLSPMDGETFSQHLQAVKVLAVKDLIWVPRHGGDIIVIGLEKDSGAQRGRVIAVLKARELNRHGVLVDAAVVAKDTVVCSFANENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase which phosphorylates RAB proteins involved in intracellular trafficking (By similarity). Phosphorylates RAB7A; this activity is dependent on protein kinase C (PKC) activation (By similarity). Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts (PubMed:23526378, PubMed:27055475). {ECO:0000250|UniProtKB:Q38SD2, ECO:0000269|PubMed:23526378, ECO:0000269|PubMed:27055475}.
uniprot
proteins
mass_dalton
225470
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated (By similarity). Autophosphorylation in inhibited in its dimeric state (By similarity). Phosphorylated by protein kinase C isozymes PRKCA, PRKCB, PRKCG, PRKCE, PRKCZ and PRKCT at Ser-1064, Ser-1074 and Thr-1075 (By similarity). Phosphorylation at these residues activates the kinase activity of LRRK1 to phosphorylate RAB7A (By similarity). {ECO:0000250|UniProtKB:Q38SD2}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
ROCO subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23526378
uniprot
proteins
pubmed
27055475
uniprot
proteins
sequence_length
2014
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q38SD2}. Cell membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q38SD2}.
uniprot
proteins