SUMO1
entrez
7341
canonical
uniprot
P63165
canonical
ensembl
ENSG00000116030
resolver
ensp
ENSP00000376075
resolver
ensp
ENSP00000376076
resolver
ensp
ENSP00000376077
resolver
ensp
ENSP00000386296
resolver
ensp
ENSP00000387204
resolver
ensp
ENSP00000770474
resolver
enst
ENST00000409368
resolver
enst
ENST00000409712
resolver
genesymbol
SUMO1
resolver
genesymbol_syn
SMT3C
resolver
genesymbol_syn
SMT3H3
resolver
genesymbol_syn
UBL1
resolver
hgnc
HGNC:12502
resolver
uniprot
A8MUS8
resolver
uniprot
B2R4I5
resolver
uniprot
B8ZZN6
resolver
uniprot
B9A032
resolver
uniprot
P55856
resolver
uniprot
Q6FGG0
resolver
uniprot
Q6NZ62
resolver
uniprot
Q93068
resolver
uniprot_entry
B8ZZN6_HUMAN
resolver
uniprot_entry
B9A032_HUMAN
resolver
uniprot_entry
SUMO1_HUMAN
resolver
uniprot_sec
A8MUS8
resolver
uniprot_sec
B2R4I5
resolver
uniprot_sec
P55856
resolver
uniprot_sec
Q6FGG0
resolver
uniprot_sec
Q6NZ62
resolver
uniprot_sec
Q93068
resolver
amino_acid_sequence
MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV
uniprot
proteins
disease_involvement
DISEASE: Non-syndromic orofacial cleft 10 (OFC10) [MIM:613705]: A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. {ECO:0000269|PubMed:16990542}. Note=The disease is caused by variants affecting the gene represented in this entry. A chromosomal aberration involving SUMO1 is the cause of OFC10. Translocation t(2;8)(q33.1;q24.3). The breakpoint occurred in the SUMO1 gene and resulted in haploinsufficiency confirmed by protein assays.
uniprot
proteins
function
FUNCTION: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:19223394, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:9019411, ECO:0000269|PubMed:9162015}.
uniprot
proteins
mass_dalton
11557
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="F->A: Abolishes binding to PIAS2."; /evidence="ECO:0000269|PubMed:16204249"; MUTAGEN 97; /note="G->A: Abolishes sumoylation of ZBED1."; /evidence="ECO:0000269|PubMed:27068747
uniprot
proteins
post_translational_modification
PTM: Cleavage of precursor form by SENP1 or SENP2 is necessary for function. {ECO:0000269|PubMed:15487983}.; PTM: Polymeric SUMO1 chains undergo polyubiquitination by RNF4. {ECO:0000269|PubMed:18408734}.
uniprot
proteins
protein_family
SUMO subfamily
uniprot
proteins
protein_family
Ubiquitin family
uniprot
proteins
pubmed
10574707
uniprot
proteins
pubmed
10961991
uniprot
proteins
pubmed
12383504
uniprot
proteins
pubmed
12565818
uniprot
proteins
pubmed
12573574
uniprot
proteins
pubmed
12606074
uniprot
proteins
pubmed
12924945
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15296745
uniprot
proteins
pubmed
15487983
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15608651
uniprot
proteins
pubmed
15660128
uniprot
proteins
pubmed
15723079
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15931224
uniprot
proteins
pubmed
15959518
uniprot
proteins
pubmed
16204249
uniprot
proteins
pubmed
16712526
uniprot
proteins
pubmed
16955485
uniprot
proteins
pubmed
16990542
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17099698
uniprot
proteins
pubmed
17956732
uniprot
proteins
pubmed
18408734
uniprot
proteins
pubmed
18538659
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18707152
uniprot
proteins
pubmed
19223394
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20388717
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21829689
uniprot
proteins
pubmed
21965678
uniprot
proteins
pubmed
22398289
uniprot
proteins
pubmed
22406621
uniprot
proteins
pubmed
23086935
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24651376
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
27068747
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
36369429
uniprot
proteins
pubmed
8806687
uniprot
proteins
pubmed
8812453
uniprot
proteins
pubmed
8906799
uniprot
proteins
pubmed
8978815
uniprot
proteins
pubmed
9019411
uniprot
proteins
pubmed
9119407
uniprot
proteins
pubmed
9162015
uniprot
proteins
pubmed
9654451
uniprot
proteins
sequence_length
101
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:10574707, ECO:0000269|PubMed:12383504}. Nucleus speckle {ECO:0000250|UniProtKB:P63166}. Cytoplasm {ECO:0000269|PubMed:12383504, ECO:0000269|PubMed:9162015}. Nucleus, PML body {ECO:0000269|PubMed:10574707, ECO:0000269|PubMed:12383504, ECO:0000269|PubMed:22406621}. Cell membrane {ECO:0000269|PubMed:19223394}. Nucleus {ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:9162015}. Note=Recruited by BCL11A into the nuclear body (By similarity). In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body (PubMed:24651376). {ECO:0000250|UniProtKB:P63166, ECO:0000269|PubMed:24651376}.
uniprot
proteins