CTBS
entrez
1486
canonical
uniprot
Q01459
canonical
ensembl
ENSG00000117151
resolver
ensp
ENSP00000359664
resolver
enst
ENST00000370630
resolver
genesymbol
CTBS
resolver
genesymbol_syn
CTB
resolver
hgnc
HGNC:2496
resolver
uniprot
Q5VX50
resolver
uniprot
Q8TC97
resolver
uniprot_entry
DIAC_HUMAN
resolver
uniprot_entry
Q8TC97_HUMAN
resolver
uniprot_sec
Q5VX50
resolver
amino_acid_sequence
MSRPQLRRWRLVSSPPSGVPGLALLALLALLALRLAAGTDCPCPEPELCRPIRHHPDFEVFVFDVGQKTWKSYDWSQITTVATFGKYDSELMCYAHSKGARVVLKGDVSLKDIIDPAFRASWIAQKLNLAKTQYMDGINIDIEQEVNCLSPEYDALTALVKETTDSFHREIEGSQVTFDVAWSPKNIDRRCYNYTGIADACDFLFVMSYDEQSQIWSECIAAANAPYNQTLTGYNDYIKMSINPKKLVMGVPWYGYDYTCLNLSEDHVCTIAKVPFRGAPCSDAAGRQVPYKTIMKQINSSISGNLWDKDQRAPYYNYKDPAGHFHQVWYDNPQSISLKATYIQNYRLRGIGMWNANCLDYSGDAVAKQQTEEMWEVLKPKLLQR
uniprot
proteins
ec_number
3.2.1.-
uniprot
proteins
function
FUNCTION: Reducing-end exoglycosidase involved in glycan degradation (PubMed:1527079, PubMed:16115860). Hydrolyzes N,N'-diacetylchitobiose (GlnNAc2) and higher chitin-oligosaccharides (GlcNAc(n)) to monomeric GlcNAc acting on reducing-end residues (PubMed:1527079, PubMed:16115860, PubMed:16794344). During N-linked glycoprotein degradation, it cleaves single GlcNAc molecules uniquely from the reducing end of N,N'-diacetylchitobiose units linking oligosaccharides to proteins, and therefore it functions after cleavage of the Asn-GlcNAc bond and asparagine removal by glycosylasparaginase (By similarity). {ECO:0000250|UniProtKB:Q01460, ECO:0000269|PubMed:1527079, ECO:0000269|PubMed:16115860, ECO:0000269|PubMed:16794344}.
uniprot
proteins
mass_dalton
43760
uniprot
proteins
pathway_participation
PATHWAY: Glycan metabolism; N-glycan degradation. {ECO:0000269|PubMed:16115860}.; PATHWAY: Glycan degradation; chitin degradation. {ECO:0000269|PubMed:16794344}.
uniprot
proteins
protein_family
Glycosyl hydrolase 18 family
uniprot
proteins
pubmed
10336991
uniprot
proteins
pubmed
1527079
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16115860
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16794344
uniprot
proteins
pubmed
19159218
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q01460}.
uniprot
proteins