PFN4
entrez
375189
canonical
uniprot
Q8NHR9
canonical
ensembl
ENSG00000176732
resolver
ensp
ENSP00000322170
resolver
ensp
ENSP00000567711
resolver
ensp
ENSP00000567712
resolver
ensp
ENSP00000567713
resolver
ensp
ENSP00000567714
resolver
ensp
ENSP00000567715
resolver
ensp
ENSP00000567716
resolver
ensp
ENSP00000567717
resolver
enst
ENST00000313213
resolver
enst
ENST00000897652
resolver
enst
ENST00000897653
resolver
enst
ENST00000897654
resolver
enst
ENST00000897655
resolver
enst
ENST00000897656
resolver
enst
ENST00000897657
resolver
enst
ENST00000897658
resolver
genesymbol
PFN4
resolver
hgnc
HGNC:31103
resolver
uniprot
Q53TL9
resolver
uniprot_entry
PROF4_HUMAN
resolver
uniprot_sec
Q53TL9
resolver
amino_acid_sequence
MSHLQSLLLDTLLGTKHVDSAALIKIQERSLCVASPGFNVTPSDVRTLVNGFAKNPLQARREGLYFKGKDYRCVRADEYSLYAKNENTGVVVVKTHLYLLVATYTEGMYPSICVEATESLGDYLRKKGS
uniprot
proteins
function
FUNCTION: Involved in male fertility. Required for manchette development and acrosome biogenesis during spermiogenesis (By similarity). Binds in vitro to phospholipids, including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA) (PubMed:19419568). Contrary to other profilin family members, does not bind to actin in vitro (PubMed:19419568). {ECO:0000250|UniProtKB:Q9D6I3, ECO:0000269|PubMed:19419568}.
uniprot
proteins
mass_dalton
14319
uniprot
proteins
protein_family
Profilin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15591451
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19419568
uniprot
proteins
pubmed
33438010
uniprot
proteins
sequence_length
129
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19419568}. Note=In round spermatids, mainly observed in the acroplaxome. During the progression of spermiogenesis, relocalizes to the developing manchette of spermatids step 8 (S8). Coinciding with the initiation of manchette disassembly in spermatids S14, seen in the cytoplasm subjacent to the disassembling manchette. {ECO:0000269|PubMed:19419568}.
uniprot
proteins