Lpin2
entrez
64898
canonical
uniprot
Q99PI5
canonical
ensembl
ENSMUSG00000024052
resolver
ensp
ENSMUSP00000118610
resolver
ensp
ENSMUSP00000119282
resolver
ensp
ENSMUSP00000232901
resolver
ensp
ENSMUSP00000232902
resolver
enst
ENSMUST00000126681
resolver
genesymbol
Lpin2
resolver
uniprot
E9PWN0
resolver
uniprot
Q8C357
resolver
uniprot
Q8C7I8
resolver
uniprot
Q8CC85
resolver
uniprot
Q8CHR7
resolver
uniprot_entry
E9PWN0_MOUSE
resolver
uniprot_entry
LPIN2_MOUSE
resolver
uniprot_sec
Q8C357
resolver
uniprot_sec
Q8C7I8
resolver
uniprot_sec
Q8CC85
resolver
uniprot_sec
Q8CHR7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethylmaleimide. {ECO:0000269|PubMed:17158099}.
uniprot
proteins
amino_acid_sequence
MNYVGQLAGQVLVTVKELYKGINQATLSGCIDVVVVRQQDGSYQCSPFHVRFGKLGVLRSKEKVIDIEINGSAVDLHMKLGDNGEAFFVEETEEEYEKLPAYLATSPIPTEDQFFKHIETPLVKSSGNERPAQSSDVSHTLESEAVFTQSSVKKKKRRRKKCKQDNRKEEQAASPVAEDVGDVGVSSDDEKRAQAARGSSNASLKEEDYKEPSLFHSGDNYPLSDGDWSPLETTYPQAVCPKSDSELEVKPSESLLRSEPHMEWTWGGFPESTKVTKRERYDYHPRTATITPSENTHFRVIPSEDSLIREVEKDATVEDTTCTIVKPKPRALCKQLSDAASTELPESPLEAPQISSLLDADPVPSPSAEAPSEPKPAAKDSPTKKKGVHKRSQHQGPDDIYLDDLKALEPEVAALYFPKSDTDPGSRQWPESDTFSGSQSPQSVGSAAADSGTECLSDSAMDLPDVTLSLCGGLSENGEISKEKFMEHIITYHEFAENPGLIDNPNLVIRIYNRYYNWALAAPMILSLQVFQKSLPKATVESWVKDKMPKKSGRWWFWRKKESMIKQLPETKEGKSEVPPANDLPSNAEEPTSARPAENDTSSDEGSQELEESIKVDPITVETLSHCGTASYKKSLRLSSDQIAKLKLHDGPNDVVFSITTQYQGTCRCAGTIYLWNWNDKVIISDIDGTITKSDALGQILPQLGKDWTHQGIARLYHSINENGYKFLYCSARAIGMADMTRGYLHWVNDKGTILPRGPLMLSPSSLFSAFHREVIEKKPEKFKIECLNDIKNLFAPSRQPFYAAFGNRPNDVYAYTQVGVPDCRIFTVNPKGELIQERTKGNKSSYHRLSELVEHVFPLLSKEQNSAFPCPEFSSFCYWRDPIPDLDLDDLA
uniprot
proteins
ec_number
3.1.3.4
uniprot
proteins
function
FUNCTION: Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane (PubMed:17158099). Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000269|PubMed:17158099, ECO:0000269|PubMed:19136718, ECO:0000269|PubMed:19717560}.
uniprot
proteins
mass_dalton
99613
uniprot
proteins
mutagenesis
MUTAGEN 731; /note="S->D: Abolishes phosphatidate phosphatase activity but does not prevent membrane association."; /evidence="ECO:0000269|PubMed:19717560"; MUTAGEN 731; /note="S->L: Abolishes phosphatidate phosphatase activity but does not prevent membrane association nor coactivator activity."; /evidence="ECO:0000269|PubMed:19717560
uniprot
proteins
protein_family
Lipin family
uniprot
proteins
pubmed
11138012
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17158099
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19136718
uniprot
proteins
pubmed
19717560
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
893
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane. Note=Translocates from cytosol to endoplasmic reticulum membrane with increasing levels of oleate.
uniprot
proteins