Elovl5
entrez
171400
canonical
uniprot
Q920L7
canonical
genesymbol
Elovl5
resolver
uniprot
G9BD46
resolver
uniprot_entry
ELOV5_RAT
resolver
uniprot_sec
G9BD46
resolver
amino_acid_sequence
MEHFDASLSTYFRALLGPRDTRVKGWFLLDNYIPTFVCSAIYLLIVWLGPKYMKNRQPFSCRGILVVYNLGLTLLSLYMFYELVTGVWEGKYNFFCQGTRSAGESDMKVIRVLWWYYFSKLIEFMDTFFFILRKNNHQITVLHVYHHATMLNIWWFVMNWVPCGHSYFGATLNSFIHVLMYSYYGLSSVPSMRPYLWWKKYITQGQLVQFVLTIIQTSCGVIWPCSFPLGWLYFQIGYMISLIALFTNFYIQTYNKKGASRRKEHLKGHQNGSMTAVNGHTNNFASLENSVTSRKQRKD
uniprot
proteins
ec_number
2.3.1.199
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity) (PubMed:22216341, PubMed:23873268). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity). {ECO:0000250|UniProtKB:Q8BHI7, ECO:0000255|HAMAP-Rule:MF_03205, ECO:0000269|PubMed:22216341, ECO:0000269|PubMed:23873268}.
uniprot
proteins
mass_dalton
35235
uniprot
proteins
mutagenesis
MUTAGEN 218; /note="S->L: No effect on fatty acid elongase activity."; /evidence="ECO:0000269|PubMed:23873268"; MUTAGEN 219; /note="C->S: No effect on fatty acid elongase activity."; /evidence="ECO:0000269|PubMed:23873268"; MUTAGEN 220; /note="G->A: No effect on fatty acid elongase activity."; /evidence="ECO:0000269|PubMed:23873268"; MUTAGEN 231; /note="W->C: Changed substrate specificity. Can elongate (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA into (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA."; /evidence="ECO:0000269|PubMed:23873268"; MUTAGEN 233; /note="Y->I: No effect on fatty acid elongase activity."; /evidence="ECO:0000269|PubMed:23873268
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03205, ECO:0000269|PubMed:22216341, ECO:0000269|PubMed:23873268}.
uniprot
proteins
protein_family
ELO family
uniprot
proteins
protein_family
ELOVL5 subfamily
uniprot
proteins
pubmed
12005057
uniprot
proteins
pubmed
22216341
uniprot
proteins
pubmed
23873268
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03205}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03205}. Cell projection, dendrite {ECO:0000255|HAMAP-Rule:MF_03205}. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree. {ECO:0000255|HAMAP-Rule:MF_03205}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03205"; TRANSMEM 64..84; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03205"; TRANSMEM 112..132; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03205"; TRANSMEM 139..158; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03205"; TRANSMEM 168..187; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03205"; TRANSMEM 205..225; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03205"; TRANSMEM 227..247; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03205
uniprot
proteins