SNRNP70
entrez
6625
canonical
uniprot
P08621
canonical
ensembl
ENSG00000104852
resolver
ensp
ENSP00000221448
resolver
ensp
ENSP00000472998
resolver
genesymbol
DKFZp434N041
resolver
genesymbol
SNRNP70
resolver
genesymbol_syn
RNPU1Z
resolver
genesymbol_syn
RPU1
resolver
genesymbol_syn
SNRNP70
resolver
genesymbol_syn
SNRP70
resolver
genesymbol_syn
U1AP1
resolver
hgnc
HGNC:11150
resolver
uniprot
B3KUA3
resolver
uniprot
P78493
resolver
uniprot
P78494
resolver
uniprot
Q15364
resolver
uniprot
Q15686
resolver
uniprot
Q15687
resolver
uniprot
Q15689
resolver
uniprot
Q99377
resolver
uniprot
Q9UE45
resolver
uniprot
Q9UE46
resolver
uniprot
Q9UE47
resolver
uniprot
Q9UE48
resolver
uniprot
Q9UFQ6
resolver
uniprot
Q9UFS1
resolver
uniprot_entry
Q9UFS1_HUMAN
resolver
uniprot_entry
RU17_HUMAN
resolver
uniprot_sec
B3KUA3
resolver
uniprot_sec
P78493
resolver
uniprot_sec
P78494
resolver
uniprot_sec
Q15364
resolver
uniprot_sec
Q15686
resolver
uniprot_sec
Q15687
resolver
uniprot_sec
Q15689
resolver
uniprot_sec
Q99377
resolver
uniprot_sec
Q9UE45
resolver
uniprot_sec
Q9UE46
resolver
uniprot_sec
Q9UE47
resolver
uniprot_sec
Q9UE48
resolver
uniprot_sec
Q9UFQ6
resolver
amino_acid_sequence
MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDRDRERRRSHRSERERRRDRDRDRDRDREHKRGERGSERGRDEARGGGGGQDNGLEGLGNDSRDMYMESEGGDGYLAPENGYLMEAAPE
uniprot
proteins
function
FUNCTION: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158). {ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2467746, ECO:0000269|PubMed:25555158}.; FUNCTION: [Isoform 3]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.; FUNCTION: [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.
uniprot
proteins
mass_dalton
51557
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.; PTM: Extensively phosphorylated on serine residues in the C-terminal region. {ECO:0000269|PubMed:8332490}.
uniprot
proteins
pubmed
10339552
uniprot
proteins
pubmed
11448987
uniprot
proteins
pubmed
11514619
uniprot
proteins
pubmed
14561889
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14765198
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17656373
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19325628
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21113136
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
2147422
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2447561
uniprot
proteins
pubmed
2467746
uniprot
proteins
pubmed
25555158
uniprot
proteins
pubmed
25911097
uniprot
proteins
pubmed
26124092
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
3028775
uniprot
proteins
pubmed
8332490
uniprot
proteins
pubmed
8746626
uniprot
proteins
pubmed
9447963
uniprot
proteins
pubmed
9531537
uniprot
proteins
sequence_length
437
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:17656373}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17656373, ECO:0000269|PubMed:21113136}. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles. {ECO:0000250|UniProtKB:Q62376}.
uniprot
proteins