Pla2g4e
entrez
329502
canonical
uniprot
Q50L42
canonical
ensembl
ENSMUSG00000050211
resolver
ensp
ENSMUSP00000087525
resolver
genesymbol
Pla2g4e
resolver
uniprot
Q8BX44
resolver
uniprot_entry
PA24E_MOUSE
resolver
uniprot_sec
Q8BX44
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by cytosolic Ca(2+) (PubMed:27399000, PubMed:29447909). Stimulated by anionic phospholipids such as phosphatidylserine (PubMed:29447909). {ECO:0000269|PubMed:27399000, ECO:0000269|PubMed:29447909}.
uniprot
proteins
amino_acid_sequence
MQSIPHSDEADVAGMTHASEGHHGLGTSMLVPKNPQGEEDSKLGRNCSGFEDAQDPQTAVPSSPLLSMASCSSQEGSSPCHLLTVRIIGMKNVRQADILSQTDCFVTLWLPTASQKKLKTRTISNCLHPEWDESFTFQIQTQVKNVLELSVCDEDTLTQNDHLLTVLYDLSKLCLRNKTHVKFPLNPEGMEELEVEFLLEENFSSSETLITNGVLVSRQVSCLEVHAESRRPRKRKKNKDLLVMVTDSFENTQRVPPCQEPCYPNSACFHYPKYSQPQLYAEAPKSHCNFRLCCCGTHRNDPVCQPLNCLSDGQVTTLPVGENYELHMKSSPCSDTLDVRLGFSLCQEEVEFVQKRKMVVAKTLSQMLQLEEGLHEDEVPIIAIMATGGGTRSMVSLYGHLLGLQKLNFLDASTYITGLSGATWTMATLYSDPEWSSKNLETVVFEARRHVVKDKMPALFPDQLYKWREDLQKHSQEGYKTTFTDFWGKLIEYSLGDKKNECKLSDQRAALCRGQNPLPIYLTINVKDDVSNQDFREWFEFSPYEVGMQKYGAFIPSELFGSEFFMGRLMKRIPEPEMCYMLGLWSSIFSLNLLDAWNLSHTSEEFFYRWTRERLHDIEDDPILPEIPRCDDNPLETTVVIPTTWLSNTFREILTRRPFVSEFHNFLYGMQLHTDYLQNRQFSMWKDTVLDTFPNQLTQFAKHLNLLDTAFFVNSSYAPLLRPERKVDLIIHLNYCAGSQTKPLKQTCEYCTEQKIPFPSFSILEDDNSLKECYVMENPQEPDAPIVAYFPLISDTFQKYKAPGVERSPDELELGQLNIYGPKSPYATKELTYTEAAFDKLVKLSEYNILNNRDKLIQALRLAMEKKRMRSQCPS
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Calcium-dependent N-acyltransferase involved in the biosynthesis of N-acyl ethanolamines (NAEs) in the brain (PubMed:27399000). Transfers the sn-1 fatty acyl chain of phosphatidylcholine (fatty acyl donor) to the amine group of phosphatidylethanolamine (fatty acyl acceptor) to generate N-acyl phosphatidylethanolamine (NAPE). Similarly can use plasmenylethanolamine as a fatty acyl acceptor to form N-acyl plasmenylethanolamine (N-Acyl-PlsEt). Both NAPE and N-Acyl-PlsEt can serve as precursors of bioactive NAEs like N-arachidonoyl phosphatidylethanolamine also called anandamide (PubMed:27399000, PubMed:29447909). Has weak phospholipase A2 and lysophospholipase activities (PubMed:15866882, PubMed:27399000). Regulates intracellular membrane trafficking that requires modulation of membrane curvature as it occurs by enrichment in lysophospholipids. Promotes tubule formation involved in clathrin-independent endocytotic trafficking and cargo recycling (PubMed:24413173). {ECO:0000269|PubMed:15866882, ECO:0000269|PubMed:24413173, ECO:0000269|PubMed:27399000, ECO:0000269|PubMed:29447909}.
uniprot
proteins
mass_dalton
100157
uniprot
proteins
mutagenesis
MUTAGEN 420; /note="S->A: Impairs calcium-dependent biosynthesis of NAPEs and NAEs. Reduces tubule growth and cargo transport from clathrin-independent endosomes."; /evidence="ECO:0000269|PubMed:24413173, ECO:0000269|PubMed:27399000
uniprot
proteins
pubmed
15866882
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24413173
uniprot
proteins
pubmed
27399000
uniprot
proteins
pubmed
29447909
uniprot
proteins
sequence_length
875
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15866882}. Early endosome membrane {ECO:0000269|PubMed:24413173, ECO:0000269|PubMed:29447909}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305|PubMed:24413173}. Lysosome membrane {ECO:0000269|PubMed:15866882, ECO:0000269|PubMed:24413173, ECO:0000269|PubMed:29447909}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305|PubMed:24413173}. Cell membrane {ECO:0000269|PubMed:24413173, ECO:0000269|PubMed:29447909}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305|PubMed:24413173}. Note=Targeted to clathrin-independent endocytotic vesicles through binding to phosphoinositides, especially phosphatidylinositol 4,5-bisphosphates. {ECO:0000269|PubMed:24413173}.
uniprot
proteins