SLC25A25
entrez
114789
canonical
uniprot
Q6KCM7
canonical
ensembl
ENSG00000148339
resolver
ensp
ENSP00000362155
resolver
ensp
ENSP00000362157
resolver
ensp
ENSP00000362159
resolver
ensp
ENSP00000362160
resolver
ensp
ENSP00000410053
resolver
genesymbol
SLC25A25
resolver
genesymbol_syn
APC3
resolver
genesymbol_syn
KIAA1896
resolver
genesymbol_syn
MCSC3
resolver
genesymbol_syn
SCAMC2
resolver
hgnc
HGNC:20663
resolver
uniprot
Q5SYW7
resolver
uniprot
Q5SYW8
resolver
uniprot
Q5SYX3
resolver
uniprot
Q5VWU2
resolver
uniprot
Q5VWU3
resolver
uniprot
Q5VWU4
resolver
uniprot
Q6KCM4
resolver
uniprot
Q6KCM6
resolver
uniprot
Q6UX48
resolver
uniprot
Q705K2
resolver
uniprot
Q96PZ1
resolver
uniprot
Q9BSA6
resolver
uniprot_entry
SCMC2_HUMAN
resolver
uniprot_sec
Q5SYW7
resolver
uniprot_sec
Q5SYW8
resolver
uniprot_sec
Q5SYX3
resolver
uniprot_sec
Q5VWU2
resolver
uniprot_sec
Q5VWU3
resolver
uniprot_sec
Q5VWU4
resolver
uniprot_sec
Q6KCM4
resolver
uniprot_sec
Q6KCM6
resolver
uniprot_sec
Q6UX48
resolver
uniprot_sec
Q705K2
resolver
uniprot_sec
Q96PZ1
resolver
uniprot_sec
Q9BSA6
resolver
activity_regulation
ACTIVITY REGULATION: Activated by an increase in cytosolic calcium levels that induces a conformational change of the N-terminal regulatory domain, uncapping the channel and allowing transport. {ECO:0000250|UniProtKB:Q6NUK1}.
uniprot
proteins
amino_acid_sequence
MLCLCLYVPVIGEAQTEFQYFESKGLPAELKSIFKLSVFIPSQEFSTYRQWKQKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR
uniprot
proteins
function
FUNCTION: Electroneutral antiporter that most probably mediates the transport of adenyl nucleotides through the inner mitochondrial membrane (By similarity). Has calcium-dependent ATP-magnesium/inorganic phosphate antiporter activity (PubMed:30080851, PubMed:34346195). Could also have a broader specificity for adenyl nucleotides (By similarity). By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways (By similarity). Acts downstream of Ca(2+)-permeable cation channel PKD2/TRPP2 and it is likely that PKD2-mediated Ca(2+) signaling activates SLC25A25 antiporter activity (By similarity). Required for left-right pattern specification (By similarity). {ECO:0000250|UniProtKB:A2CEQ0, ECO:0000250|UniProtKB:Q6NUK1, ECO:0000269|PubMed:30080851, ECO:0000269|PubMed:34346195}.
uniprot
proteins
mass_dalton
52663
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
11572484
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15054102
uniprot
proteins
pubmed
15123600
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
30080851
uniprot
proteins
pubmed
34346195
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:15054102, ECO:0000305|PubMed:15123600, ECO:0000305|PubMed:30080851}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 190..207; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 245..264; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 288..301; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 338..357; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 381..398; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 438..457; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins