CERK
entrez
64781
canonical
uniprot
Q8TCT0
canonical
ensembl
ENSG00000100422
resolver
ensp
ENSP00000216264
resolver
genesymbol
CERK
resolver
genesymbol_syn
KIAA1646
resolver
hgnc
HGNC:19256
resolver
uniprot
A0JNT4
resolver
uniprot
A8K611
resolver
uniprot
Q6NX59
resolver
uniprot
Q9BYB3
resolver
uniprot
Q9UGE5
resolver
uniprot_entry
CERK1_HUMAN
resolver
uniprot_sec
A0JNT4
resolver
uniprot_sec
A8K611
resolver
uniprot_sec
Q6NX59
resolver
uniprot_sec
Q9BYB3
resolver
uniprot_sec
Q9UGE5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by sulfatide (PubMed:19168031). Inhibited by sphinganine, sphingenine, and N,N-Dimethylsphingosine (DMS) (PubMed:16269826). Cardiolipin at 0.1 uM significantly increases activity, whereas at concentrations >1 uM has an inhibitory effect (PubMed:27725450). {ECO:0000269|PubMed:16269826, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:27725450}.
uniprot
proteins
amino_acid_sequence
MGATGAAEPLQSVLWVKQQRCAVSLEPARALLRWWRSPGPGAGAPGADACSVPVSEIIAVEETDVHGKHQGSGKWQKMEKPYAFTVHCVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLREMLEKLTSRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGSTDCVCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDSEKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVCRQSKQQLEEEQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDLILIRKCSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKHMEDEDSDLKEGGKKRFGHICSSHPSCCCTVSNSSWNCDGEVLHSPAIEVRVHCQLVRLFARGIEENPKPDSHS
uniprot
proteins
ec_number
2.7.1.138
uniprot
proteins
function
FUNCTION: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:11956206, PubMed:16269826, PubMed:19168031). Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:11956206, PubMed:16269826, PubMed:17392267, PubMed:19168031). Shows a greater preference for D-erythro isomer of ceramides (PubMed:16269826). Binds phosphoinositides (PubMed:19168031). {ECO:0000269|PubMed:11956206, ECO:0000269|PubMed:16269826, ECO:0000269|PubMed:17392267, ECO:0000269|PubMed:19168031}.
uniprot
proteins
mass_dalton
59977
uniprot
proteins
mutagenesis
MUTAGEN 10; /note="L->A: 99% decrease in catalytic activity but no effect on substrate affinity."; /evidence="ECO:0000269|PubMed:16081073"; MUTAGEN 10; /note="L->I: 71% decrease in catalytic activity but no effect on substrate affinity."; /evidence="ECO:0000269|PubMed:16081073"; MUTAGEN 340; /note="S->A: 15% decrease in catalytic activity and decreased stability."; /evidence="ECO:0000269|PubMed:19899769
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11258795
uniprot
proteins
pubmed
11956206
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16081073
uniprot
proteins
pubmed
16269826
uniprot
proteins
pubmed
17392267
uniprot
proteins
pubmed
19168031
uniprot
proteins
pubmed
19899769
uniprot
proteins
pubmed
27725450
uniprot
proteins
sequence_length
537
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16269826}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:17392267}.
uniprot
proteins