PES1
entrez
23481
canonical
uniprot
O00541
canonical
ensembl
ENSG00000100029
resolver
ensp
ENSP00000334612
resolver
ensp
ENSP00000346725
resolver
ensp
ENSP00000384366
resolver
ensp
ENSP00000385654
resolver
enst
ENST00000402281
resolver
enst
ENST00000405677
resolver
genesymbol
PES1
resolver
hgnc
HGNC:8848
resolver
uniprot
A0ACM8QBP1
resolver
uniprot
A1NV65
resolver
uniprot
A6NNS1
resolver
uniprot
B2RDF2
resolver
uniprot
B3KTZ6
resolver
uniprot
F6VXF5
resolver
uniprot
Q6IC29
resolver
uniprot_entry
A0ACM8QBP1_HUMAN
resolver
uniprot_entry
B2RDF2_HUMAN
resolver
uniprot_entry
B3KTZ6_HUMAN
resolver
uniprot_entry
F6VXF5_HUMAN
resolver
uniprot_entry
PESC_HUMAN
resolver
uniprot_sec
A1NV65
resolver
uniprot_sec
A6NNS1
resolver
uniprot_sec
Q6IC29
resolver
amino_acid_sequence
MGGLEKKKYERGSATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHKKKVNKGSTAARTFYLIKDIRFLLHEPIVNKFREYKVFVRKLRKAYGKSEWNTVERLKDNKPNYKLDHIIKERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLTVEFMHYIIAARALRKVFLSIKGIYYQAEVLGQPIVWITPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQLLNLHYPPKLEGQAQAEAKAGEGTYALDSESCMEKLAALSASLARVVVPATEEEAEVDEFPTDGEMSAQEEDRRKELEAQEKHKKLFEGLKFFLNREVPREALAFIIRSFGGEVSWDKSLCIGATYDVTDSRITHQIVDRPGQQTSVIGRCYVQPQWVFDSVNARLLLPVAEYFSGVQLPPHLSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAKKARPE
uniprot
proteins
function
FUNCTION: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03028, ECO:0000269|PubMed:16738141, ECO:0000269|PubMed:17189298, ECO:0000269|PubMed:17353269}.
uniprot
proteins
mass_dalton
68003
uniprot
proteins
mutagenesis
MUTAGEN 327; /note="F->R: Reduces incorporation into the PeBoW complex and nucleolar localization and impairs maturation of 28S ribosomal RNA."; /evidence="ECO:0000269|PubMed:17189298"; MUTAGEN 347; /note="I->R: Reduces incorporation into the PeBoW complex and nucleolar localization and impairs maturation of 28S ribosomal RNA."; /evidence="ECO:0000269|PubMed:17189298"; MUTAGEN 380; /note="R->W: Slightly impairs nucleolar localization."; /evidence="ECO:0000269|PubMed:17189298"; MUTAGEN 397; /note="W->R: Reduces incorporation into the PeBoW complex and nucleolar localization and impairs maturation of 28S ribosomal RNA."; /evidence="ECO:0000269|PubMed:17189298
uniprot
proteins
post_translational_modification
PTM: Sumoylated.
uniprot
proteins
protein_family
Pescadillo family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11071894
uniprot
proteins
pubmed
12022229
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16043514
uniprot
proteins
pubmed
16738141
uniprot
proteins
pubmed
17189298
uniprot
proteins
pubmed
17353269
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25825154
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
8985183
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli. {ECO:0000255|HAMAP-Rule:MF_03028}.
uniprot
proteins