Ptgis
entrez
25527
canonical
uniprot
Q62969
canonical
ensembl
ENSRNOG00000008245
resolver
ensembl
ENSRNOG00055004622
resolver
ensembl
ENSRNOG00060001060
resolver
ensembl
ENSRNOG00065013008
resolver
ensp
ENSRNOP00000087709
resolver
ensp
ENSRNOP00055005500
resolver
ensp
ENSRNOP00060000674
resolver
ensp
ENSRNOP00065016469
resolver
enst
ENSRNOT00000115486
resolver
enst
ENSRNOT00055007342
resolver
enst
ENSRNOT00060001442
resolver
enst
ENSRNOT00065021309
resolver
genesymbol
Ptgis
resolver
genesymbol_syn
Cyp8
resolver
uniprot_entry
PTGIS_RAT
resolver
amino_acid_sequence
MSWAALLGLLAVLLLLLLLLSRRRARRPGEPPLDLGSIPWLGHALEFGKDAASFLTRMKEKHGDIFTVLVGGRYVTVLLDPHSYDTVVWDLRTRLDFHPYAIFLMERIFDLQLPNFNPSEEKARMKPTLMHKDLQALTEAMYTNLRTVLLGDSTEGGSGWQEKGLLEFSYSSLLSAGYLTLYGVEASPRTHESQALDRDHSADVFRTFRQLDLMLPKLARGSLSVGDKDHACSVKSRLWKLLSPAGLASRADRSSWLESYLRHLEEMGVSEDMQARALVLQLWATQGNMGPTAFWLLLFLLKNPEALDAVHAELKRIVWQAEKPVLQMTALPQKILDSMPVLDSVLNETLRLTAAPFITREVMADLALPMADRREFSLRRGDRLLLFPFLSPQKDPEIYTEPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNQCLGKSYAINSIKQFVVLLLTHFDLELVSEDTEVPEFDLSRYGFGLMQPEEDVPIRYRTRL
uniprot
proteins
ec_number
4.2.1.152
uniprot
proteins
ec_number
5.3.99.4
uniprot
proteins
function
FUNCTION: Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation. Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE). {ECO:0000250|UniProtKB:Q16647}.
uniprot
proteins
mass_dalton
57128
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q29626}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 1..21; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins