Obox1
entrez
71468
canonical
uniprot
Q9D350
canonical
ensembl
ENSMUSG00000054310
resolver
ensp
ENSMUSP00000067691
resolver
ensp
ENSMUSP00000133504
resolver
ensp
ENSMUSP00000134043
resolver
ensp
ENSMUSP00000134688
resolver
ensp
ENSMUSP00000138010
resolver
enst
ENSMUST00000067288
resolver
enst
ENSMUST00000172463
resolver
enst
ENSMUST00000172881
resolver
enst
ENSMUST00000173443
resolver
enst
ENSMUST00000181001
resolver
genesymbol
Obox1
resolver
uniprot
G3UX03
resolver
uniprot_entry
OBOX1_MOUSE
resolver
uniprot_sec
G3UX03
resolver
amino_acid_sequence
MAEGPSLHPKLQVDSNIPIEISSQIPQEPARNLAFQMRQSPLVTPGSTTKSSLSVPERNLLKQESQGPSRQSGCMLLSDKYVNKQTGPMASRKFRKERTVYTKEQQGLLQKHFDECQYPNKKKIVELALSVGVTKREIKIWFKNNRAKYRRMNLQNIEQVLPESNGSSKAVSESTHFPVVASDNGESMCSGTFGEDSIPKFNCS
uniprot
proteins
function
FUNCTION: Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:37459895). Together with other Obox family members, required in early two-cell stage embryos to kick-start the major ZGA wave by facilitating RNA Polymerase II 'pre-configuration', during which RNA Polymerase II relocates from the initial one-cell stage binding targets to ZGA gene promoters and distal enhancers (PubMed:37459895). Mechanistically, promotes recruitment of RNA Polymerase II from (CG-rich) non-ZGA genes to (CG-poor) ZGA genes at the two-cell stage (PubMed:37459895). Binds to regulatory DNA sequences containing a 5'-ACNCCTTTAATCCCAG-3' sequence motif (PubMed:37459895). Most maternal and zygotic Obox family proteins can compensate for one another (PubMed:37459895). In addition to its role in ZGA, promotes embryonic stem cell pluripotency (PubMed:29033306). {ECO:0000269|PubMed:29033306, ECO:0000269|PubMed:37459895}.
uniprot
proteins
mass_dalton
22875
uniprot
proteins
protein_family
Obox subfamily
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
11991721
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
29033306
uniprot
proteins
pubmed
37459895
uniprot
proteins
sequence_length
204
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
uniprot
proteins