ATP13A4
entrez
84239
canonical
uniprot
Q4VNC1
canonical
ensembl
ENSG00000127249
resolver
ensp
ENSP00000339182
resolver
ensp
ENSP00000692762
resolver
genesymbol
ATP13A4
resolver
hgnc
HGNC:25422
resolver
uniprot
B3KU47
resolver
uniprot
B7WPC7
resolver
uniprot
Q6UY23
resolver
uniprot
Q8N1Q9
resolver
uniprot
Q9H043
resolver
uniprot_entry
AT134_HUMAN
resolver
uniprot_entry
B3KU47_HUMAN
resolver
uniprot_sec
B7WPC7
resolver
uniprot_sec
Q6UY23
resolver
uniprot_sec
Q8N1Q9
resolver
uniprot_sec
Q9H043
resolver
amino_acid_sequence
MGHFEKGQHALLNEGEENEMEIFGYRTQGCRKSLCLAGSIFSFGILPLVFYWRPAWHVWAHCVPCSLQEADTVLLRTTDEFQIYSWKKVIWIYLSALNSAFGLTPDHPLMTDEEYIINRAIRKPDLKVRCIKVQKIRYVWNYLEGQFQKIGSLEDWLSSAKIHQKFGSGLTREEQEIRRLICGPNTIDVEVTPIWKLLIKEVLNPFYIFQLFSVCLWFSEDYKEYAFAIIIMSIISISLTVYDLREQSVKLHHLVESHNSITVSVCGRKAGVQELESRVLVPGDLLILTGNKVLMPCDAVLIEGSCVVDEGMLTGESIPVTKTPLPKMDSSVPWKTQSEADYKRHVLFCGTEVIQAKAACSGTVRAVVLQTGFNTAKGDLVRSILYPKPVNFQLYRDAIRFLLCLVGTATIGMIYTLCVYVLSGEPPEEVVRKALDVITIAVPPALPAALTTGIIYAQRRLKKRGIFCISPQRINVCGQLNLVCFDKTGTLTRDGLDLWGVVSCDRNGFQEVHSFASGQALPWGPLCAAMASCHSLILLDGTIQGDPLDLKMFEATTWEMAFSGDDFHIKGVPAHAMVVKPCRTASQVPVEGIAILHQFPFSSALQRMTVIVQEMGGDRLAFMKGAPERVASFCQPETVPTSFVSELQIYTTQGFRVIALAYKKLENDHHATTLTRETVESDLIFLGLLILENRLKEETKPVLEELISARIRTVMITGDNLQTAITVARKSGMVSESQKVILIEANETTGSSSASISWTLVEEKKHIMYGNQDNYINIRDEVSDKGREGSYHFALTGKSFHVISQHFSSLLPKILINGTIFARMSPGQKSSLVEEFQKLDYFVGMCGDGANDCGALKMAHVGISLSEQEASVASPFTSKTPNIECVPHLIKEGRAALVTSFCMFKYMALYSMIQYVGVLLLYWETNSLSNYQFLFQDLAITTLIGVTMNLNGAYPKLVPFRPAGRLISPPLLLSVIFNILLSLAMHIAGFILVQRQPWYSVEIHSACTVQNESISELTMSPTAPEKMESNSTFTSFENTTVWFLGTINCITVALVFSKGKPFRQPTYTNYIFVLVLIIQLGVCLFILFADIPELYRRLDLLCTPVLWRASIVIMLSLNFIVSLVAEEAVIENRALWMMIKRCFGYQSKSQYRIWQRDLANDPSWPPLNQTSHSDMPECGRGVSYSNPVFESNEEQL
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving ATP13A4 is found in 2 patients with specific language impairment (SLI) disorders. Paracentric inversion inv(3)(q25;q29). The inversion produces a disruption of the protein. {ECO:0000269|PubMed:15925480}.
uniprot
proteins
ec_number
7.2.2.-
uniprot
proteins
function
FUNCTION: Polyamine transporter mediating cellular uptake of putrescine, spermidine and spermine (Probable). May be involved in the regulation of intracellular calcium levels (By similarity). {ECO:0000250|UniProtKB:Q5XF90, ECO:0000305|PubMed:37371498}.
uniprot
proteins
mass_dalton
133987
uniprot
proteins
mutagenesis
MUTAGEN 486; /note="D->N: Loss of putrescine, spermidine and spermine uptake."; /evidence="ECO:0000269|PubMed:37371498
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type V subfamily
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15925480
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
29505581
uniprot
proteins
pubmed
37371498
uniprot
proteins
sequence_length
1196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q5XF90}. Early endosome membrane {ECO:0000250|UniProtKB:Q5XF90}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q5XF90}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q5XF90}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 198..218; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 401..421; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 437..457; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 901..921; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 933..953; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 973..993; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1036..1056; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1071..1091; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1110..1130; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins