IRAG2
entrez
4033
canonical
uniprot
Q12912
canonical
ensembl
ENSG00000118308
resolver
ensp
ENSP00000346442
resolver
ensp
ENSP00000444056
resolver
ensp
ENSP00000446496
resolver
ensp
ENSP00000450246
resolver
ensp
ENSP00000451048
resolver
ensp
ENSP00000452116
resolver
ensp
ENSP00000489956
resolver
ensp
ENSP00000548467
resolver
ensp
ENSP00000548468
resolver
ensp
ENSP00000548469
resolver
ensp
ENSP00000548470
resolver
ensp
ENSP00000610971
resolver
enst
ENST00000536173
resolver
genesymbol
IRAG2
resolver
genesymbol_syn
JAW1
resolver
genesymbol_syn
LRMP
resolver
hgnc
HGNC:6690
resolver
uniprot
A0AVM2
resolver
uniprot
B4E077
resolver
uniprot
F5H006
resolver
uniprot
Q8N301
resolver
uniprot_entry
F5H006_HUMAN
resolver
uniprot_entry
IRAG2_HUMAN
resolver
uniprot_sec
A0AVM2
resolver
uniprot_sec
B4E077
resolver
uniprot_sec
Q8N301
resolver
amino_acid_sequence
MESTPFSGVANQIHTLCERPTYGEVKDGALDVKRQHKCPGPTSGPSPGTNLSGCIRMNDDPSMEENGVERVCPESLLQSREYSSLPLPRHTSSTDGTITSSDPGLEILNMASCDLDRNSLCKKEEDTRSASPTIEAQGTSPAHDNIAFQDSTSKDKTILNLEAKEEPETIEEHKKEHASGDSVVSPLPVTTVKSVNLRQSENTSANEKEVEAEFLRLSLGFKCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPLCEDDNQAQEIIKKLEKSIKFLSQCAARVASRAEMLGAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQNERSFNPLEDDDDCQIKKRSASLNSKPSSLRRVTIASLPRNIGNAGMVAGMENNDRFSRRSSSWRILGSKQSEHRPSLPRFISTYSWADAEEEKCELKTKDDSEPSGEETVERTRKPSLSEKKNNPSKWDVSSVYDTIASWATNLKSSIRKANKALWLSIAFIVLFAALMSFLTGQLFQKSVDAAPTQQEDSWTSLEHILWPFTRLRHNGPPPV
uniprot
proteins
function
FUNCTION: Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}.
uniprot
proteins
mass_dalton
62122
uniprot
proteins
post_translational_modification
PTM: The removal of the C-terminal lumenal domain occurs by proteolytic processing. {ECO:0000250}.
uniprot
proteins
protein_family
IRAG2 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16739114
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8021504
uniprot
proteins
sequence_length
555
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Processed inositol 1,4,5-triphosphate receptor associated 2]: Cytoplasm {ECO:0000250|UniProtKB:Q60664}.; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q60664}; Single-pass type IV membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000250|UniProtKB:Q60664}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5RHB5}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q5RHB5}. Chromosome {ECO:0000250|UniProtKB:Q5RHB5}. Note=Colocalized with ITPR3 on the endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q60664}.
uniprot
proteins
transmembrane_region
TRANSMEM 496..516; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins