Diablo
entrez
66593
canonical
uniprot
Q9JIQ3
canonical
ensembl
ENSMUSG00000029433
resolver
ensp
ENSMUSP00000107214
resolver
ensp
ENSMUSP00000115045
resolver
enst
ENSMUST00000111587
resolver
enst
ENSMUST00000125652
resolver
genesymbol
Diablo
resolver
genesymbol_syn
Smac
resolver
uniprot
Q542V8
resolver
uniprot
Q9CZD1
resolver
uniprot
Q9DCD3
resolver
uniprot_entry
DBLOH_MOUSE
resolver
uniprot_sec
Q542V8
resolver
uniprot_sec
Q9CZD1
resolver
uniprot_sec
Q9DCD3
resolver
amino_acid_sequence
MAALRSWVTRSVCSLFRYRQRFPVLANSKKRCFSELIKPWHKTVLTGFGMTLCAVPIAQKSEPQSLSNEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLVSLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASITARNHIQLVKSQVQEVRQLSQKAETKLAEAQTKELHQKAQEVSDEGADQEEEAYLRED
uniprot
proteins
function
FUNCTION: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/BRUCE by inhibiting its binding to caspases (By similarity). {ECO:0000250|UniProtKB:Q9NR28, ECO:0000269|PubMed:10929712}.
uniprot
proteins
mass_dalton
26820
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by BIRC7/livin. Ubiquitinated by BIRC6. {ECO:0000250|UniProtKB:Q9NR28}.; PTM: The precursor form is proteolytically cleaved by mitochondrial processing peptidase MPP to remove the transit peptide and produce an intermediate form. This is then processed by PARL to produce the mature cleaved form which is released from mitochondria into the cytosol in apoptotic cells. {ECO:0000250|UniProtKB:Q9NR28}.
uniprot
proteins
protein_family
Smac/DIABLO protein family
uniprot
proteins
pubmed
10929712
uniprot
proteins
pubmed
15178455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23479728
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10929712}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9NR28}. Note=Released into the cytosol in a PARL-dependent manner when cells undergo apoptosis. {ECO:0000250|UniProtKB:Q9NR28}.
uniprot
proteins