Aqp3
entrez
65133
canonical
uniprot
P47862
canonical
ensembl
ENSRNOG00000009797
resolver
ensembl
ENSRNOG00055016831
resolver
ensembl
ENSRNOG00060003749
resolver
ensembl
ENSRNOG00065004787
resolver
ensp
ENSRNOP00000013803
resolver
ensp
ENSRNOP00055023042
resolver
ensp
ENSRNOP00060004631
resolver
ensp
ENSRNOP00065004733
resolver
enst
ENSRNOT00000013803
resolver
enst
ENSRNOT00055028604
resolver
enst
ENSRNOT00060006225
resolver
enst
ENSRNOT00065006920
resolver
genesymbol
Aqp3
resolver
uniprot
A0A0G2JSK0
resolver
uniprot
A0JPL5
resolver
uniprot_entry
A0A0G2JSK0_RAT
resolver
uniprot_entry
AQP3_RAT
resolver
uniprot_sec
A0JPL5
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is inhibited by mercury ions. {ECO:0000269|PubMed:7517548}.
uniprot
proteins
amino_acid_sequence
MGRQKELMNRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWAFAGNELVVSGPNGTAGIFATYPSGHLDMVNGFFDQFIGTAALIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSEVFTTGQNWWWVPIVSPLLGSIGGVFVYQLMIGCHLEQPPPSTEAENVKLAHMKHKEQI
uniprot
proteins
function
FUNCTION: Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:7517548, PubMed:7526388). Could also be permeable to urea (PubMed:7517548, PubMed:7526388). Also participates in cell permeability to H2O2 and H2O2-mediated signaling (By similarity). In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair. In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance (By similarity). {ECO:0000250|UniProtKB:Q8R2N1, ECO:0000250|UniProtKB:Q92482, ECO:0000269|PubMed:7517548, ECO:0000269|PubMed:7526388}.
uniprot
proteins
mass_dalton
31384
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7517548
uniprot
proteins
pubmed
7526388
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7517548, ECO:0000269|PubMed:7526388}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14520}. Basolateral cell membrane {ECO:0000269|PubMed:7517548}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14520}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..42; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 57..74; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 101..121; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 160..177; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 190..206; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 243..264; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O14520
uniprot
proteins