Ppara
entrez
19013
canonical
uniprot
P23204
canonical
ensembl
ENSMUSG00000022383
resolver
ensp
ENSMUSP00000059719
resolver
ensp
ENSMUSP00000105049
resolver
ensp
ENSMUSP00000105050
resolver
ensp
ENSMUSP00000255233
resolver
ensp
ENSMUSP00000255242
resolver
ensp
ENSMUSP00000255249
resolver
enst
ENSMUST00000057979
resolver
enst
ENSMUST00000109422
resolver
enst
ENSMUST00000109423
resolver
genesymbol
Ppara
resolver
genesymbol_syn
Nr1c1
resolver
genesymbol_syn
Ppar
resolver
uniprot
Q542P9
resolver
uniprot_entry
PPARA_MOUSE
resolver
uniprot_entry
Q542P9_MOUSE
resolver
amino_acid_sequence
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
uniprot
proteins
disease_involvement
DISEASE: Note=Peroxisome proliferators are a diverse group of chemicals that include hypolipidaemic drugs, herbicides and industrial plasticisers. Administration of these chemicals to rodents results in the dramatic proliferation of hepatic peroxisomes as well as liver hyperplasia.
uniprot
proteins
function
FUNCTION: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:12955147, ECO:0000269|PubMed:19646743, ECO:0000269|PubMed:20159955}.
uniprot
proteins
mass_dalton
52347
uniprot
proteins
mutagenesis
MUTAGEN 119; /note="C->A: Reduces DNA binding and strongly decreases transcriptional activation; when associated with A-122."; /evidence="ECO:0000269|PubMed:19646743"; MUTAGEN 122; /note="C->A: Reduces DNA binding and strongly decreases transcriptional activation; when associated with A-119."; /evidence="ECO:0000269|PubMed:19646743"; MUTAGEN 292; /note="K->A: No effect on interaction with PER2."; /evidence="ECO:0000269|PubMed:20159955"; MUTAGEN 459..468; /note="Missing: Slightly reduces interaction with PER2."; /evidence="ECO:0000269|PubMed:20159955
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by E3 ubiquitin-protein ligase HUWE1; leading to proteasomal degradation. {ECO:0000269|PubMed:28683290}.; PTM: Phosphorylated. {ECO:0000250|UniProtKB:P37230}.
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10788465
uniprot
proteins
pubmed
12955147
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16950137
uniprot
proteins
pubmed
18719582
uniprot
proteins
pubmed
19646743
uniprot
proteins
pubmed
20159955
uniprot
proteins
pubmed
2129546
uniprot
proteins
pubmed
28683290
uniprot
proteins
pubmed
29331071
uniprot
proteins
pubmed
7588749
uniprot
proteins
pubmed
8123021
uniprot
proteins
pubmed
9325263
uniprot
proteins
pubmed
9627117
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:20159955}.
uniprot
proteins