Dlx5
entrez
13395
canonical
uniprot
P70396
canonical
ensembl
ENSMUSG00000029755
resolver
ensp
ENSMUSP00000052559
resolver
ensp
ENSMUSP00000138264
resolver
genesymbol
Dlx5
resolver
uniprot
O54876
resolver
uniprot
O54877
resolver
uniprot
O54878
resolver
uniprot
Q3TYA7
resolver
uniprot
Q9JJ45
resolver
uniprot_entry
DLX5_MOUSE
resolver
uniprot_entry
Q3TYA7_MOUSE
resolver
uniprot_sec
O54876
resolver
uniprot_sec
O54877
resolver
uniprot_sec
O54878
resolver
uniprot_sec
Q9JJ45
resolver
amino_acid_sequence
MTGVFDRRVPSIRSGDFQAPFPTSAAMHHPSQESPTLPESSATDSDYYSPAGAAPHGYCSPTSASYGKALNPYQYQYHGVNGSAAGYPAKAYADYGYASPYHQYGGAYNRVPSATSQPEKEVAEPEVRMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNKRSKIKKIMKNGEMPPEHSPSSSDPMACNSPQSPAVWEPQGSSRSLSHHPHAHPPTSNQSPASSYLENSASWYPSAASSINSHLPPPGSLQHPLALASGTLY
uniprot
proteins
function
FUNCTION: Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. {ECO:0000269|PubMed:15383550, ECO:0000269|PubMed:18056716, ECO:0000269|PubMed:19956613}.
uniprot
proteins
mass_dalton
31396
uniprot
proteins
mutagenesis
MUTAGEN 34; /note="S->A: Inhibits its transcriptional activity; when associated with A-217."; /evidence="ECO:0000269|PubMed:18056716"; MUTAGEN 217; /note="S->A: Inhibits its transcriptional activity; when associated with A-34."; /evidence="ECO:0000269|PubMed:18056716
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation of Ser-34 and Ser-217 by MAPK14 enhances its transcriptional activity. Phosphorylation by CaMK2 increases its protein stability. {ECO:0000269|PubMed:18056716, ECO:0000269|PubMed:19393622}.
uniprot
proteins
protein_family
Distal-less homeobox family
uniprot
proteins
pubmed
10075846
uniprot
proteins
pubmed
15383550
uniprot
proteins
pubmed
18056716
uniprot
proteins
pubmed
19393622
uniprot
proteins
pubmed
19956613
uniprot
proteins
pubmed
8855272
uniprot
proteins
pubmed
9415433
uniprot
proteins
pubmed
9763476
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:18056716}.
uniprot
proteins