ANP32B
entrez
10541
canonical
uniprot
Q92688
canonical
ensembl
ENSG00000136938
resolver
ensp
ENSP00000345848
resolver
genesymbol
ANP32B
resolver
genesymbol_syn
APRIL
resolver
genesymbol_syn
PHAPI2
resolver
hgnc
HGNC:16677
resolver
uniprot
B2R9C7
resolver
uniprot
O00655
resolver
uniprot
P78458
resolver
uniprot
P78459
resolver
uniprot_entry
AN32B_HUMAN
resolver
uniprot_sec
B2R9C7
resolver
uniprot_sec
O00655
resolver
uniprot_sec
P78458
resolver
uniprot_sec
P78459
resolver
amino_acid_sequence
MDMKRRIHLELRNRTPAAVRELVLDNCKSNDGKIEGLTAEFVNLEFLSLINVGLISVSNLPKLPKLKKLELSENRIFGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDLFNCEVTNLNDYRESVFKLLPQLTYLDGYDREDQEAPDSDAEVDGVDEEEEDEEGEDEEDEDDEDGEEEEFDEEDDEDEDVEGDEDDDEVSEEEEEFGLDEEDEDEDEDEEEEEGGKGEKRKRETDDEGEDD
uniprot
proteins
function
FUNCTION: Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q9EST5, ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:18039846, ECO:0000269|PubMed:20015864, ECO:0000269|PubMed:20538007}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A and B viral genome replication (PubMed:31217244, PubMed:33045004). Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:31217244, ECO:0000269|PubMed:33045004}.
uniprot
proteins
mass_dalton
28788
uniprot
proteins
mutagenesis
MUTAGEN 163; /note="D->A: Complete loss of cleavage by CASP3."; /evidence="ECO:0000269|PubMed:20015864
uniprot
proteins
post_translational_modification
PTM: Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity). {ECO:0000250}.; PTM: Directly cleaved by caspase-3/CASP3. {ECO:0000269|PubMed:20015864}.
uniprot
proteins
protein_family
ANP32 family
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15895553
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17178712
uniprot
proteins
pubmed
18039846
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20015864
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20538007
uniprot
proteins
pubmed
21159877
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24823948
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
31217244
uniprot
proteins
pubmed
31793855
uniprot
proteins
pubmed
33045004
uniprot
proteins
pubmed
9473664
uniprot
proteins
sequence_length
251
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:24823948, ECO:0000269|PubMed:31217244}. Cytoplasm {ECO:0000269|PubMed:17178712}. Note=Accumulates in the nuclei at the S phase. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Note=Lacks a nuclear localization signal.
uniprot
proteins