Lamtor2
entrez
83409
canonical
uniprot
Q9JHS3
canonical
ensembl
ENSMUSG00000028062
resolver
ensp
ENSMUSP00000029698
resolver
ensp
ENSMUSP00000285312
resolver
enst
ENSMUST00000029698
resolver
genesymbol
Lamtor2
resolver
genesymbol_syn
Mapbpip
resolver
genesymbol_syn
Robld3
resolver
uniprot_entry
LTOR2_MOUSE
resolver
amino_acid_sequence
MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDSLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS
uniprot
proteins
function
FUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (By similarity). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (By similarity). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (PubMed:15263099). {ECO:0000250|UniProtKB:Q9Y2Q5, ECO:0000269|PubMed:15263099}.
uniprot
proteins
mass_dalton
13480
uniprot
proteins
protein_family
GAMAD family
uniprot
proteins
pubmed
11266467
uniprot
proteins
pubmed
15016825
uniprot
proteins
pubmed
15263099
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15740743
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19177150
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
125
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:11266467, ECO:0000269|PubMed:15263099, ECO:0000269|PubMed:19177150}; Peripheral membrane protein {ECO:0000269|PubMed:19177150}; Cytoplasmic side {ECO:0000269|PubMed:19177150}. Lysosome membrane {ECO:0000269|PubMed:11266467}; Peripheral membrane protein {ECO:0000269|PubMed:19177150}; Cytoplasmic side {ECO:0000269|PubMed:19177150}. Note=Recruited to lysosome and endosome membranes by LAMTOR1. {ECO:0000269|PubMed:19177150}.
uniprot
proteins