INTS13
entrez
55726
canonical
uniprot
Q9NVM9
canonical
ensembl
ENSG00000064102
resolver
ensp
ENSP00000261191
resolver
ensp
ENSP00000445645
resolver
ensp
ENSP00000562666
resolver
ensp
ENSP00000562667
resolver
ensp
ENSP00000562668
resolver
ensp
ENSP00000562671
resolver
ensp
ENSP00000562672
resolver
ensp
ENSP00000562674
resolver
ensp
ENSP00000616692
resolver
genesymbol
INTS13
resolver
genesymbol_syn
ASUN
resolver
genesymbol_syn
C12orf11
resolver
genesymbol_syn
GCT1
resolver
hgnc
HGNC:20174
resolver
uniprot
B4DNK1
resolver
uniprot
Q86WE2
resolver
uniprot
Q96HM2
resolver
uniprot
Q9BTX2
resolver
uniprot
Q9NTB6
resolver
uniprot
Q9NVM5
resolver
uniprot_entry
INT13_HUMAN
resolver
uniprot_sec
B4DNK1
resolver
uniprot_sec
Q86WE2
resolver
uniprot_sec
Q96HM2
resolver
uniprot_sec
Q9BTX2
resolver
uniprot_sec
Q9NTB6
resolver
uniprot_sec
Q9NVM5
resolver
amino_acid_sequence
MKIFSESHKTVFVVDHCPYMAESCRQHVEFDMLVKNRTQGIIPLAPISKSLWTCSVESSMEYCRIMYDIFPFKKLVNFIVSDSGAHVLNSWTQEDQNLQELMAALAAVGPPNPRADPECCSILHGLVAAVETLCKITEYQHEARTLLMENAERVGNRGRIICITNAKSDSHVRMLEDCVQETIHEHNKLAANSDHLMQIQKCELVLIHTYPVGEDSLVSDRSKKELSPVLTSEVHSVRAGRHLATKLNILVQQHFDLASTTITNIPMKEEQHANTSANYDVELLHHKDAHVDFLKSGDSHLGGGSREGSFKETITLKWCTPRTNNIELHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKSGSKVISHMLSSHGGEIFLHVLSSSRSILEDPPSISEGCGGRVTDYRITDFGEFMRENRLTPFLDPRYKIDGSLEVPLERAKDQLEKHTRYWPMIISQTTIFNMQAVVPLASVIVKESLTEEDVLNCQKTIYNLVDMERKNDPLPISTVGTRGKGPKRDEQYRIMWNELETLVRAHINNSEKHQRVLECLMACRSKPPEEEERKKRGRKREDKEDKSEKAVKDYEQEKSWQDSERLKGILERGKEELAEAEIIKDSPDSPEPPNKKPLVEMDETPQVEKSKGPVSLLSLWSNRINTANSRKHQEFAGRLNSVNNRAELYQHLKEENGMETTENGKASRQ
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:32647223). Within the integrator complex, INTS13 is part of the integrator tail module and acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386, PubMed:38906142). At prophase, mediates recruitment of cytoplasmic dynein to the nuclear envelope, a step important for proper centrosome-nucleus coupling (PubMed:23097494, PubMed:23904267). At G2/M phase, may be required for proper spindle formation and execution of cytokinesis (PubMed:23097494, PubMed:23904267). {ECO:0000269|PubMed:23097494, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:32647223, ECO:0000269|PubMed:38570683, ECO:0000269|PubMed:38823386, ECO:0000269|PubMed:38906142}.
uniprot
proteins
mass_dalton
80225
uniprot
proteins
mutagenesis
MUTAGEN 123..127; /note="LHGLV->RHGLE: Abolished interaction with transcription factor ZNF655."; /evidence="ECO:0000269|PubMed:38906142"; MUTAGEN 174..178; /note="MLEDC->RLEDR: Abolished interaction with transcription factor ZNF655."; /evidence="ECO:0000269|PubMed:38906142"; MUTAGEN 345..353; /note="RPSSCLTNF->APSSCLTNA: Abolished interaction with transcription factors."; /evidence="ECO:0000269|PubMed:38906142"; MUTAGEN 577..582; /note="REDKED->AAAAAA: Loss of nuclear location. Location is mainly cytoplasmic or diffuse. Loss of Dynein recruitment to nuclear envelope."; /evidence="ECO:0000269|PubMed:23904267
uniprot
proteins
protein_family
Integrator subunit 13 family
uniprot
proteins
pubmed
12414650
uniprot
proteins
pubmed
12601173
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15737938
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23097494
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23904267
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
32647223
uniprot
proteins
pubmed
38570683
uniprot
proteins
pubmed
38823386
uniprot
proteins
pubmed
38906142
uniprot
proteins
pubmed
39032490
uniprot
proteins
sequence_length
706
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:39032490}. Cytoplasm {ECO:0000269|PubMed:23097494, ECO:0000269|PubMed:23904267}. Note=Nuclear location is required for recruitment of dynein motors to nuclear envelope at G2/M. {ECO:0000269|PubMed:17974005}.
uniprot
proteins