ARFGAP1
entrez
55738
canonical
uniprot
Q8N6T3
canonical
ensembl
ENSG00000101199
resolver
ensp
ENSP00000314615
resolver
ensp
ENSP00000359298
resolver
ensp
ENSP00000359306
resolver
ensp
ENSP00000430500
resolver
ensp
ENSP00000443716
resolver
ensp
ENSP00000576927
resolver
ensp
ENSP00000645055
resolver
ensp
ENSP00000722310
resolver
genesymbol
ARFGAP1
resolver
genesymbol_syn
ARF1GAP
resolver
hgnc
HGNC:15852
resolver
uniprot
B7Z3U0
resolver
uniprot
B7Z8H8
resolver
uniprot
B7ZBI3
resolver
uniprot
E1P5I9
resolver
uniprot
E7EV62
resolver
uniprot
Q53F62
resolver
uniprot
Q6PK71
resolver
uniprot
Q96KC4
resolver
uniprot
Q96T02
resolver
uniprot
Q9NSU3
resolver
uniprot
Q9NVF6
resolver
uniprot
Q9UIL0
resolver
uniprot_entry
ARFG1_HUMAN
resolver
uniprot_entry
Q53F62_HUMAN
resolver
uniprot_sec
B7Z3U0
resolver
uniprot_sec
B7Z8H8
resolver
uniprot_sec
B7ZBI3
resolver
uniprot_sec
E1P5I9
resolver
uniprot_sec
E7EV62
resolver
uniprot_sec
Q6PK71
resolver
uniprot_sec
Q96KC4
resolver
uniprot_sec
Q96T02
resolver
uniprot_sec
Q9NSU3
resolver
uniprot_sec
Q9NVF6
resolver
uniprot_sec
Q9UIL0
resolver
amino_acid_sequence
MASPRTRKVLKEVRVQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLESQEDYDPCWSLQEKYNSRAAALFRDKVVALAEGREWSLESSPAQNWTPPQPRTLPSMVHRVSGQPQSVTASSDKAFEDWLNDDLGSYQGAQGNRYVGFGNTPPPQKKEDDFLNNAMSSLYSGWSSFTTGASRFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGKIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEGPLDSPSEGHSYQNSGLDHFQNSNIDQSFWETFGSAEPTKTRKSPSSDSWTCADTSTERRSSDSWEVWGSASTNRNSNSDGGEGGEGTKKAVPPAVPTDDGWDNQNW
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine. {ECO:0000250|UniProtKB:Q62848}.
uniprot
proteins
mass_dalton
44668
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:Q62848}. Cytoplasm {ECO:0000250|UniProtKB:Q62848}. Note=Associates with the Golgi complex. {ECO:0000250|UniProtKB:Q62848}.
uniprot
proteins