Qsox1
entrez
104009
canonical
uniprot
Q8BND5
canonical
ensembl
ENSMUSG00000033684
resolver
ensp
ENSMUSP00000035658
resolver
ensp
ENSMUSP00000142301
resolver
genesymbol
Qsox1
resolver
genesymbol_syn
Qscn6
resolver
genesymbol_syn
Sox
resolver
uniprot
Q3TDY9
resolver
uniprot
Q3TE19
resolver
uniprot
Q3TR29
resolver
uniprot
Q3UEL4
resolver
uniprot
Q8K041
resolver
uniprot
Q9DBL6
resolver
uniprot_entry
QSOX1_MOUSE
resolver
uniprot_sec
Q3TDY9
resolver
uniprot_sec
Q3TE19
resolver
uniprot_sec
Q3TR29
resolver
uniprot_sec
Q3UEL4
resolver
uniprot_sec
Q8K041
resolver
uniprot_sec
Q9DBL6
resolver
amino_acid_sequence
MRRCGRLSGPPSLLLLLLLLSPLLFSGPGAYAARLSVLYSSSDPLTLLDADSVRPTVLGSSSAWAVEFFASWCGHCIAFAPTWKELANDVKDWRPALNLAVLDCAEETNSAVCREFNIAGFPTVRFFQAFTKNGSGATLPGAGANVQTLRMRLIDALESHRDTWPPACPPLEPAKLNDIDGFFTRNKADYLALVFEREDSYLGREVTLDLSQYHAVAVRRVLNTESDLVNKFGVTDFPSCYLLLRNGSVSRVPVLVESRSFYTSYLRGLPGLTRDAPPTTATPVTADKIAPTVWKFADRSKIYMADLESALHYILRVEVGKFSVLEGQRLVALKKFVAVLAKYFPGQPLVQNFLHSINDWLQKQQKKRIPYSFFKAALDSRKEDAVLTEKVNWVGCQGSEPHFRGFPCSLWVLFHFLTVQANRYSEAHPQEPADGQEVLQAMRSYVQFFFGCRDCADHFEQMAAASMHQVRSPSNAILWLWTSHNRVNARLSGALSEDPHFPKVQWPPRELCSACHNELNGQVPLWDLGATLNFLKAHFSPANIVIDSSASRHTGRRGSPEATPELVMDTLKLESRNSVLGHEQAASAESPGATALDVPAEKPEASGPQELYTGLRMGGASPGQGPPERMEDHQRDMQENAPGQQHLSKRDTEALFLPEVNHLQGPLELRRGGRSPKQLAPILEEEPEALAIQGQGQWLQVLGGGISHLDISLCVGLYSVSFMGLLAMYTYFRARLRTPKGHASYPTA
uniprot
proteins
ec_number
1.8.3.2
uniprot
proteins
function
FUNCTION: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:26819240). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:26819240). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:26819240). {ECO:0000269|PubMed:26819240}.
uniprot
proteins
mass_dalton
82785
uniprot
proteins
mutagenesis
MUTAGEN 75; /note="H->A: Causes local perturbations of protein folding; when associated with T-122."; /evidence="ECO:0000269|PubMed:30367560"; MUTAGEN 122; /note="P->T: Causes local perturbations of protein folding; when associated with T-122."; /evidence="ECO:0000269|PubMed:30367560
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. O-glycosylated on Thr and Ser residues. {ECO:0000250|UniProtKB:O00391}.
uniprot
proteins
protein_family
Quiescin-sulfhydryl oxidase (QSOX) family
uniprot
proteins
pubmed
12354420
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22801504
uniprot
proteins
pubmed
26819240
uniprot
proteins
pubmed
30367560
uniprot
proteins
sequence_length
748
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus membrane {ECO:0000250|UniProtKB:O00391}; Single-pass membrane protein {ECO:0000250|UniProtKB:O00391}. Secreted {ECO:0000269|PubMed:26819240}. Note=A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor. {ECO:0000250|UniProtKB:O00391}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:12354420}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 711..731; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins