Nudt7
entrez
67528
canonical
uniprot
Q99P30
canonical
ensembl
ENSMUSG00000031767
resolver
ensp
ENSMUSP00000073213
resolver
ensp
ENSMUSP00000104737
resolver
ensp
ENSMUSP00000114598
resolver
ensp
ENSMUSP00000116868
resolver
ensp
ENSMUSP00000313157
resolver
genesymbol
Nudt7
resolver
uniprot
Q6IS65
resolver
uniprot
Q8BU08
resolver
uniprot
Q8K260
resolver
uniprot
Q9D0Q3
resolver
uniprot
Q9DBI9
resolver
uniprot_entry
NUDT7_MOUSE
resolver
uniprot_sec
Q6IS65
resolver
uniprot_sec
Q8BU08
resolver
uniprot_sec
Q8K260
resolver
uniprot_sec
Q9D0Q3
resolver
uniprot_sec
Q9DBI9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by fluoride.
uniprot
proteins
amino_acid_sequence
MSRPCGLPEPVRNNLIDDAKARLRKSDVGTRYSHLSSNKFSVLVPLLARGGKLYLMFTVRSDKLKREPGEVCFPGGKRDPVDTDDTATALREAQEEVGLHPHQVEVVSHLVPYVFDNDALVTPVVGFLDHNFQAQPNADEVKEVFFVPLDYFLHPQVYYQKQITQSGRDFIMHCFEYKDPETGVNYLIQGMTSKLAVLVALIILEQSPAFKIDFDLHDLIPSCERTFLWRYSLSKL
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
ec_number
3.6.1.77
uniprot
proteins
function
FUNCTION: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (PubMed:11415433, PubMed:18799520, PubMed:29378847). Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies (PubMed:11415433). Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs (PubMed:18799520). Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester (PubMed:18799520). May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand (PubMed:18799520). Does not play a role in U8 snoRNA decapping activity (PubMed:21070968). Binds U8 snoRNA (PubMed:21070968). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673). {ECO:0000269|PubMed:11415433, ECO:0000269|PubMed:18799520, ECO:0000269|PubMed:21070968, ECO:0000269|PubMed:29378847, ECO:0000269|PubMed:32432673}.
uniprot
proteins
mass_dalton
26857
uniprot
proteins
mutagenesis
MUTAGEN 60; /note="R->M: 2- to 3-fold increase in Km for CoA."; /evidence="ECO:0000269|PubMed:29378847"; MUTAGEN 65; /note="K->A: 3-fold increase in Km for CoA."; /evidence="ECO:0000269|PubMed:29378847"; MUTAGEN 66; /note="R->A: 10-fold increase in Km for CoA."; /evidence="ECO:0000269|PubMed:29378847"; MUTAGEN 66; /note="R->M: No significant effect on Km for CoA."; /evidence="ECO:0000269|PubMed:29378847"; MUTAGEN 79; /note="D->A: No significant effect on Km for CoA."; /evidence="ECO:0000269|PubMed:29378847"; MUTAGEN 92; /note="E->A: Loss of fatty acyl-coenzyme A diphosphatase activity."; /evidence="ECO:0000269|PubMed:29378847"; MUTAGEN 95; /note="E->A: No significant effect on Km for CoA."; /evidence="ECO:0000269|PubMed:29378847"; MUTAGEN 96; /note="E->A: Loss of fatty acyl-coenzyme A diphosphatase activity."; /evidence="ECO:0000269|PubMed:29378847
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
protein_family
PCD1 subfamily
uniprot
proteins
pubmed
11415433
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18799520
uniprot
proteins
pubmed
21070968
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
29378847
uniprot
proteins
pubmed
32432673
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:11415433, ECO:0000269|PubMed:18799520}.
uniprot
proteins