Twf1
entrez
19230
canonical
uniprot
Q91YR1
canonical
ensembl
ENSMUSG00000022451
resolver
ensp
ENSMUSP00000023087
resolver
enst
ENSMUST00000023087
resolver
genesymbol
Twf1
resolver
genesymbol_syn
Ptk9
resolver
uniprot
O09132
resolver
uniprot
Q52L77
resolver
uniprot
Q80X09
resolver
uniprot_entry
TWF1_MOUSE
resolver
uniprot_sec
O09132
resolver
uniprot_sec
Q52L77
resolver
uniprot_sec
Q80X09
resolver
amino_acid_sequence
MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVVGSCSPPSDSWEQDYDSFVLPLLEDKQPCYVLFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVSVDTKHQTLQGVAFPISRDAFQALEKLSKKQLNYVQLEIDIKNETIILANTENTELRDLPKRIPKDSARYHFFLYKHSHEGDYLESVVFIYSMPGYTCSIRERMLYSSCKSPLLEIVERQLQMDVIRKIEIDNGDELTADFLYDEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAEAEATTD
uniprot
proteins
function
FUNCTION: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. {ECO:0000269|PubMed:10669753, ECO:0000269|PubMed:15282541, ECO:0000269|PubMed:16511569, ECO:0000269|PubMed:9249064}.
uniprot
proteins
mass_dalton
40079
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues. {ECO:0000250|UniProtKB:Q12792}.
uniprot
proteins
protein_family
Actin-binding proteins ADF family
uniprot
proteins
protein_family
Twinfilin subfamily
uniprot
proteins
pubmed
10669753
uniprot
proteins
pubmed
12207032
uniprot
proteins
pubmed
12807912
uniprot
proteins
pubmed
15282541
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16511569
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19768801
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9249064
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10669753}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10669753}. Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts.
uniprot
proteins