Mc4r
entrez
25635
canonical
uniprot
P70596
canonical
ensembl
ENSRNOG00055010601
resolver
ensembl
ENSRNOG00060010841
resolver
ensembl
ENSRNOG00065023286
resolver
ensp
ENSRNOP00055014447
resolver
ensp
ENSRNOP00060014302
resolver
ensp
ENSRNOP00065032358
resolver
enst
ENSRNOT00055017943
resolver
enst
ENSRNOT00060018344
resolver
enst
ENSRNOT00065039777
resolver
genesymbol
Mc4r
resolver
uniprot_entry
MC4R_RAT
resolver
amino_acid_sequence
MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Functions as a central component of the leptin-melanocortin pathway, which is essential for maintaining energy homeostasis. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which promotes anorexogenic signaling in the hypothalamus and contributes to a negative energy balance. Regulates food intake: activation by agonists suppresses appetite, whereas the antagonist Agouti-related protein/AGRP precludes agonist-induced signaling, thereby stimulating appetite. Modulates the firing activity of neurons in paraventricular nucleus (PVN) of the hypothalamus via alpha-MSH and AGRP regulation of inwardly rectifying potassium channel KCNJ13 closure, independently of G(s) signaling. In the PVN, also interacts with opsin 3/OPN3, which couples to G(i/o) proteins to inhibit MC4R-mediated cAMP signaling, thereby promoting food intake. In intestinal epithelial cells, contributes to inhibition of hepatic glucose production via nesfatin-1/NUCB2, leading to increased cAMP levels and glucagon-like peptide 1 (GLP-1) secretion. Interaction with MGRN1 displaces the G(s) protein, further decreasing MC4R signaling activity. Also activated by gamma-MSH, though with low potency. {ECO:0000250|UniProtKB:P32245}.
uniprot
proteins
mass_dalton
36887
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
8794897
uniprot
proteins
sequence_length
332
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P32245}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:P32245}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P32245}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..63; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P32245"; TRANSMEM 84..107; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P32245"; TRANSMEM 119..145; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P32245"; TRANSMEM 167..188; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P32245"; TRANSMEM 192..214; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P32245"; TRANSMEM 244..267; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P32245"; TRANSMEM 280..302; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P32245
uniprot
proteins