P97305
uniprot
P97305
canonical
amino_acid_sequence
MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPADLEPDDCASIYIFNVDPPPSTLTTPLCLPHHGLPSHSSVLSPSFQLQSHKNYEGTCEIPESKYSPLGGPKPFECPSIQFTSISPNCQQELDAHEDDLQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGSGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSEDQAAILPGKLEICSDDQGNLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGGPHWEVEGKIIREKCQGAHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLPSVPSLPVPHSAQAQRPSSETGHPHDRAMSAPGGLLCQVQPAYTSMVASTHLPQLQCRDEGAGKEQHIATSSVMHQPFQVTPTSPIGSSYQSIQTSMYNGPTCLPVNPASSQEFDPVLFQQDAALSSLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSNAGQTALSSPVADQITGQPSSHLQPITYCPSHPGSATAASPAASHPLASSPISGPSSPQLQPMPYQSPSSGTASSPSPTTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGATVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQISVSQATEVMRDTPLPGPASPDLMTSHSAH
uniprot
proteins
function
FUNCTION: Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (PubMed:21514407). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (PubMed:21514407). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (PubMed:20495147, PubMed:21525433). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (PubMed:20495147, PubMed:21525433). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (PubMed:19538478). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (PubMed:12750314). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (By similarity). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (PubMed:17579027). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (PubMed:24970700). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:Q12968, ECO:0000269|PubMed:12750314, ECO:0000269|PubMed:17579027, ECO:0000269|PubMed:19538478, ECO:0000269|PubMed:20495147, ECO:0000269|PubMed:21514407, ECO:0000269|PubMed:21525433, ECO:0000269|PubMed:24970700}.
uniprot
proteins
mass_dalton
115451
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by STUB1/CHIP, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q12968}.; PTM: Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin. {ECO:0000269|PubMed:7650004}.
uniprot
proteins
pubmed
10089876
uniprot
proteins
pubmed
12370307
uniprot
proteins
pubmed
12750314
uniprot
proteins
pubmed
17198697
uniprot
proteins
pubmed
17579027
uniprot
proteins
pubmed
19538478
uniprot
proteins
pubmed
20495147
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21514407
uniprot
proteins
pubmed
21525433
uniprot
proteins
pubmed
24970700
uniprot
proteins
pubmed
25215946
uniprot
proteins
pubmed
7650004
uniprot
proteins
pubmed
9017603
uniprot
proteins
sequence_length
1075
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21525433, ECO:0000269|PubMed:24970700}. Nucleus {ECO:0000269|PubMed:20495147, ECO:0000269|PubMed:21514407, ECO:0000269|PubMed:21525433, ECO:0000269|PubMed:24970700, ECO:0000269|PubMed:25215946}. Note=The subcellular localization of NFATC plays a key role in the regulation of gene transcription (Probable). Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals (Probable). Cytoplasmic when phosphorylated and nuclear after activation, that is controlled by calcineurin-mediated dephosphorylation (Probable). Translocation to the nucleus is increased in the presence of calcium in pre-osteoblasts (PubMed:21514407). Translocates to the nucleus in the presence of EDN1 following colocalization with F-actin filaments, translocation is ROCK-dependent (PubMed:20495147, PubMed:21525433). Translocates to the nucleus in response to lipopolysaccharide treatment of macrophages (PubMed:24970700). {ECO:0000269|PubMed:20495147, ECO:0000269|PubMed:21514407, ECO:0000269|PubMed:21525433, ECO:0000269|PubMed:24970700, ECO:0000305|PubMed:10089876}.
uniprot
proteins