Ngef
entrez
53972
canonical
uniprot
Q8CHT1
canonical
ensembl
ENSMUSG00000026259
resolver
ensp
ENSMUSP00000027477
resolver
ensp
ENSMUSP00000066894
resolver
enst
ENSMUST00000068681
resolver
genesymbol
Ngef
resolver
uniprot
E9QK62
resolver
uniprot
Q8R204
resolver
uniprot
Q923H2
resolver
uniprot
Q9JHT9
resolver
uniprot_entry
E9QK62_MOUSE
resolver
uniprot_entry
NGEF_MOUSE
resolver
uniprot_sec
Q8R204
resolver
uniprot_sec
Q923H2
resolver
uniprot_sec
Q9JHT9
resolver
amino_acid_sequence
METKNSEDWGKPQRKSESSSRKSNHGPAEMRPALPPENREAPETGEETQNEEPRRLIPIQRHSLFNRAVRHRHKARSTSERRASDQADLPKMGKSVNERSAFNLPQGRLSPWRTPAQRDTGAQEASESSSTPGNGTTPEECPALTDSPTTLTEALQMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIQGNSDGSQVGEDAGEEEEEEEEGEEEELASPPERRALPQICLLSNPHSRFNLWQDLPEIQSSGVLDILQPEEIRLQEAMFELVTSEASYYKSLNLLVSHFMENERLKKILHPSEAHILFSNVLDVMAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCKGLPFSSFLILPFQRITRLKLLVQNILKRVEERSEREGTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILEKTEDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRVHKMEDPQRSQNKDRRKLGSRNRQ
uniprot
proteins
function
FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension. {ECO:0000269|PubMed:11336673, ECO:0000269|PubMed:15848799, ECO:0000269|PubMed:17143272}.
uniprot
proteins
mass_dalton
82199
uniprot
proteins
mutagenesis
MUTAGEN 177; /note="Y->F: Loss of ephrin-mediated growth cone collapse. No effect on interaction with EPHA4."; /evidence="ECO:0000269|PubMed:15848799
uniprot
proteins
post_translational_modification
PTM: Src-dependent phosphorylation at Tyr-177 upon EPHA4 activation increases the guanine exchange factor activity toward RHOA. Phosphorylation by CDK5 upon EPHA4 activation by EFNA1 may regulate dendritic spine morphogenesis. {ECO:0000269|PubMed:15254079, ECO:0000269|PubMed:17143272}.
uniprot
proteins
pubmed
10777665
uniprot
proteins
pubmed
11336673
uniprot
proteins
pubmed
15142957
uniprot
proteins
pubmed
15254079
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15848799
uniprot
proteins
pubmed
17143272
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
710
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Associated with membranes. Localizes to axonal growth cones (By similarity). {ECO:0000250}.
uniprot
proteins