MARK3
entrez
4140
canonical
uniprot
P27448
canonical
ensembl
ENSG00000075413
resolver
ensp
ENSP00000216288
resolver
ensp
ENSP00000303698
resolver
ensp
ENSP00000402104
resolver
ensp
ENSP00000411397
resolver
ensp
ENSP00000450460
resolver
ensp
ENSP00000450772
resolver
ensp
ENSP00000454169
resolver
ensp
ENSP00000502861
resolver
ensp
ENSP00000502999
resolver
ensp
ENSP00000503216
resolver
ensp
ENSP00000503568
resolver
ensp
ENSP00000504493
resolver
ensp
ENSP00000504622
resolver
ensp
ENSP00000543504
resolver
ensp
ENSP00000543505
resolver
ensp
ENSP00000543506
resolver
ensp
ENSP00000543508
resolver
ensp
ENSP00000543512
resolver
ensp
ENSP00000543515
resolver
ensp
ENSP00000582986
resolver
ensp
ENSP00000678246
resolver
ensp
ENSP00000681220
resolver
enst
ENST00000560417
resolver
enst
ENST00000676938
resolver
enst
ENST00000677360
resolver
enst
ENST00000677432
resolver
enst
ENST00000677829
resolver
enst
ENST00000678237
resolver
enst
ENST00000678619
resolver
genesymbol
MARK3
resolver
genesymbol_syn
CTAK1
resolver
genesymbol_syn
EMK2
resolver
hgnc
HGNC:6897
resolver
uniprot
A0A0A0MQR8
resolver
uniprot
A0A0A0MST9
resolver
uniprot
A0A0A0MT23
resolver
uniprot
A0A7I2V2E3
resolver
uniprot
A0A7I2V2N8
resolver
uniprot
A0A7I2V3B9
resolver
uniprot
A0A7I2V5G3
resolver
uniprot
A0A7I2V639
resolver
uniprot
A0A7I2YQF7
resolver
uniprot
H0YNV4
resolver
uniprot
O60219
resolver
uniprot
Q86TT8
resolver
uniprot
Q86U11
resolver
uniprot
Q8TB41
resolver
uniprot
Q8WX83
resolver
uniprot
Q96RG1
resolver
uniprot
Q9UMY9
resolver
uniprot
Q9UN34
resolver
uniprot_entry
A0A7I2V2E3_HUMAN
resolver
uniprot_entry
A0A7I2V2N8_HUMAN
resolver
uniprot_entry
A0A7I2V3B9_HUMAN
resolver
uniprot_entry
A0A7I2V5G3_HUMAN
resolver
uniprot_entry
A0A7I2V639_HUMAN
resolver
uniprot_entry
A0A7I2YQF7_HUMAN
resolver
uniprot_entry
H0YNV4_HUMAN
resolver
uniprot_entry
MARK3_HUMAN
resolver
uniprot_entry
Q86U11_HUMAN
resolver
uniprot_sec
A0A0A0MQR8
resolver
uniprot_sec
A0A0A0MST9
resolver
uniprot_sec
A0A0A0MT23
resolver
uniprot_sec
O60219
resolver
uniprot_sec
Q86TT8
resolver
uniprot_sec
Q8TB41
resolver
uniprot_sec
Q8WX83
resolver
uniprot_sec
Q96RG1
resolver
uniprot_sec
Q9UMY9
resolver
uniprot_sec
Q9UN34
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-211. Inhibited by phosphorylation on Thr-564. {ECO:0000269|PubMed:14976552}.
uniprot
proteins
amino_acid_sequence
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
uniprot
proteins
disease_involvement
DISEASE: Visual impairment and progressive phthisis bulbi (VIPB) [MIM:618283]: An autosomal recessive, progressive disease characterized by poor vision at birth and development of bilateral phthisis bulbi by adulthood. {ECO:0000269|PubMed:29771303}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}.
uniprot
proteins
mass_dalton
84429
uniprot
proteins
mutagenesis
MUTAGEN 211; /note="T->A: Prevents phosphorylation and activation by STK11/LKB1 complex."; /evidence="ECO:0000269|PubMed:14976552
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (PubMed:14976552). Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity (PubMed:15084291). {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15084291}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SNF1 subfamily
uniprot
proteins
pubmed
11433294
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12941695
uniprot
proteins
pubmed
14976552
uniprot
proteins
pubmed
15084291
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16822840
uniprot
proteins
pubmed
16959763
uniprot
proteins
pubmed
16980613
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21145462
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23666762
uniprot
proteins
pubmed
28087714
uniprot
proteins
pubmed
29771303
uniprot
proteins
pubmed
9543386
uniprot
proteins
sequence_length
753
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21145462}; Peripheral membrane protein {ECO:0000269|PubMed:21145462}. Cell projection, dendrite {ECO:0000269|PubMed:23666762}. Cytoplasm {ECO:0000269|PubMed:23666762}.
uniprot
proteins