MCM3
entrez
4172
canonical
uniprot
P25205
canonical
ensembl
ENSG00000112118
resolver
ensp
ENSP00000229854
resolver
ensp
ENSP00000388647
resolver
ensp
ENSP00000472940
resolver
ensp
ENSP00000530115
resolver
ensp
ENSP00000530119
resolver
ensp
ENSP00000609934
resolver
ensp
ENSP00000754991
resolver
enst
ENST00000229854
resolver
enst
ENST00000419835
resolver
genesymbol
MCM3
resolver
hgnc
HGNC:6945
resolver
uniprot
A0A0S2Z492
resolver
uniprot
A0A0S2Z4T1
resolver
uniprot
A0A499FHX9
resolver
uniprot
B4DUQ9
resolver
uniprot
B4DWW4
resolver
uniprot
J3KQ69
resolver
uniprot
Q92660
resolver
uniprot
Q9BTR3
resolver
uniprot
Q9NUE7
resolver
uniprot_entry
A0A0S2Z492_HUMAN
resolver
uniprot_entry
A0A0S2Z4T1_HUMAN
resolver
uniprot_entry
A0A499FHX9_HUMAN
resolver
uniprot_entry
B4DUQ9_HUMAN
resolver
uniprot_entry
J3KQ69_HUMAN
resolver
uniprot_entry
MCM3_HUMAN
resolver
uniprot_sec
B4DWW4
resolver
uniprot_sec
Q92660
resolver
uniprot_sec
Q9BTR3
resolver
uniprot_sec
Q9NUE7
resolver
amino_acid_sequence
MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQKVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEEPFSSVEIQAALSKMQDDNQVMVSEGIIFLI
uniprot
proteins
ec_number
3.6.4.12
uniprot
proteins
function
FUNCTION: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}.
uniprot
proteins
mass_dalton
90981
uniprot
proteins
mutagenesis
MUTAGEN 535; /note="S->A: 50% reduction in phosphorylation by ATM or ATR."; /evidence="ECO:0000269|PubMed:15210935
uniprot
proteins
post_translational_modification
PTM: Acetylated by MCM3AP. {ECO:0000269|PubMed:11258703, ECO:0000269|PubMed:12226073}.; PTM: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. {ECO:0000269|PubMed:22967762}.
uniprot
proteins
protein_family
MCM family
uniprot
proteins
pubmed
11258703
uniprot
proteins
pubmed
12226073
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15210935
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1549468
uniprot
proteins
pubmed
16899510
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17296731
uniprot
proteins
pubmed
17487921
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22967762
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23711367
uniprot
proteins
pubmed
32453425
uniprot
proteins
pubmed
34694004
uniprot
proteins
pubmed
34700328
uniprot
proteins
pubmed
35585232
uniprot
proteins
pubmed
7758114
uniprot
proteins
pubmed
8265339
uniprot
proteins
pubmed
9712829
uniprot
proteins
sequence_length
808
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000305|PubMed:35585232}.
uniprot
proteins