Adat2
entrez
66757
canonical
uniprot
Q6P6J0
canonical
ensembl
ENSMUSG00000019808
resolver
ensp
ENSMUSP00000019944
resolver
enst
ENSMUST00000019944
resolver
genesymbol
Adat2
resolver
genesymbol_syn
Deadc1
resolver
uniprot
Q9CX14
resolver
uniprot_entry
ADAT2_MOUSE
resolver
uniprot_sec
Q9CX14
resolver
amino_acid_sequence
MEEKVESTTTPDGPCVVSVQETEKWMEEAMRMAKEALENIEVPVGCLMVYNNEVVGKGRNEVNQTKNATRHAEMVAIDQVLDWCHQHGQSPSTVFEHTVLYVTVEPCIMCAAALRLMKIPLVVYGCQNERFGGCGSVLNIASADLPNTGRPFQCIPGYRAEEAVELLKTFYKQENPNAPKSKVRKKDCQKS
uniprot
proteins
ec_number
3.5.4.33
uniprot
proteins
function
FUNCTION: Catalytic subunit of the tRNA-specific adenosine-34 deaminase complex, composed of the ADAT2 catalytic subunit and the ADAT3 regulatory subunit, which deaminates adenosine-34 (the first, also called wobble position of the anticodon) to inosine in many tRNAs (PubMed:34057470). Inosine-34 allows the decoding of 3 different nucleotides at the third position of mRNA codons, as inosine is able to pair with U, C, and A (PubMed:34057470). Binding of the ADAT2-ADAT3 complex to tRNA is mediated by the N-terminus of ADAT3 which rotates with respect to the catalytic domain of the complex, formed by ADAT2 and the ADAT3 C-terminal domain, to position the tRNA anticodon stem-loop correctly in the ADAT2 active site (PubMed:34057470). The ADAT2-ADAT3 complex is required for radial migration of projection neurons in the developing brain cortex, and the catalytic activity of the complex is necessary for this function (PubMed:40120092). {ECO:0000269|PubMed:34057470, ECO:0000269|PubMed:40120092}.
uniprot
proteins
mass_dalton
21308
uniprot
proteins
mutagenesis
MUTAGEN 73; /note="E->A: Almost complete loss of activity. Reduces neuronal migration in the embryonic cortex. Loss of activity; when associated with 'E-225' of ADAT3."; /evidence="ECO:0000269|PubMed:34057470
uniprot
proteins
protein_family
ADAT2 subfamily
uniprot
proteins
protein_family
Cytidine and deoxycytidylate deaminase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34057470
uniprot
proteins
pubmed
40120092
uniprot
proteins
sequence_length
191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:40120092}. Cytoplasm {ECO:0000269|PubMed:40120092}. Note=The ADAT2-ADAT3 complex shows a diffuse expression pattern in both the cytoplasm and the nucleus. {ECO:0000269|PubMed:40120092}.
uniprot
proteins