CCR6
entrez
1235
canonical
uniprot
P51684
canonical
ensembl
ENSG00000112486
resolver
ensp
ENSP00000339393
resolver
ensp
ENSP00000343952
resolver
ensp
ENSP00000383715
resolver
ensp
ENSP00000493637
resolver
ensp
ENSP00000554693
resolver
ensp
ENSP00000554694
resolver
ensp
ENSP00000554695
resolver
ensp
ENSP00000554696
resolver
enst
ENST00000341935
resolver
enst
ENST00000349984
resolver
enst
ENST00000400926
resolver
enst
ENST00000643861
resolver
enst
ENST00000884634
resolver
enst
ENST00000884635
resolver
enst
ENST00000884636
resolver
enst
ENST00000884637
resolver
genesymbol
CCR6
resolver
genesymbol_syn
CKRL3
resolver
genesymbol_syn
CMKBR6
resolver
genesymbol_syn
GPR29
resolver
genesymbol_syn
STRL22
resolver
hgnc
HGNC:1607
resolver
uniprot
E1P5C6
resolver
uniprot
P78553
resolver
uniprot
Q92846
resolver
uniprot_entry
CCR6_HUMAN
resolver
uniprot_sec
E1P5C6
resolver
uniprot_sec
P78553
resolver
uniprot_sec
Q92846
resolver
amino_acid_sequence
MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM
uniprot
proteins
function
FUNCTION: Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988). {ECO:0000250|UniProtKB:O54689, ECO:0000269|PubMed:20068036, ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:25122636, ECO:0000269|PubMed:9169459, ECO:0000303|PubMed:21376174, ECO:0000303|PubMed:25585877}.
uniprot
proteins
mass_dalton
42494
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="C->A: No loss of calcium flux but loss of chemotaxis in response to CCL20 stimulation. No effect on cell surface expression."; /evidence="ECO:0000269|PubMed:12081481"; MUTAGEN 36; /note="C->D,G: Loss of calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression."; /evidence="ECO:0000269|PubMed:12081481"; MUTAGEN 36; /note="C->S: No loss of calcium flux but loss of chemotaxis in response to CCL20 stimulation, impaired CCL20-binding and no effect on cell surface expression; when associated with or without S-288. Loss of calcium flux in response to CCL20 stimulation and significant reduction in cell surface expression; when associated with S-118; S-197 and S-288."; /evidence="ECO:0000269|PubMed:12081481"; MUTAGEN 57; /note="C->S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression."; /evidence="ECO:0000269|PubMed:12081481"; MUTAGEN 118; /note="C->S: Loss of calcium flux and chemotaxis in response to CCL20 stimulation, impaired CCL20-binding and significant reduction in cell surface expression; when associated with or without S-197. Loss of calcium flux in response to CCL20 stimulation and significant reduction in cell surface expression; when associated with S-36; S-197 and S-288."; /evidence="ECO:0000269|PubMed:12081481"; MUTAGEN 131; /note="C->S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression."; /evidence="ECO:0000269|PubMed:12081481"; MUTAGEN 138; /note="C->S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression."; /evidence="ECO:0000269|PubMed:12081481"; MUTAGEN 168; /note="C->S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression."; /evidence="ECO:0000269|PubMed:12081481"; MUTAGEN 197; /note="C->S: Loss of calcium flux and chemotaxis in response to CCL20 stimulation, impaired CCL20-binding and significant reduction in cell surface expression; when associated with or without S-118. Loss of calcium flux in response to CCL20 stimulation and significant reduction in cell surface expression; when associated with S-36; S-118 and S-288."; /evidence="ECO:0000269|PubMed:12081481"; MUTAGEN 233; /note="C->S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression."; /evidence="ECO:0000269|PubMed:12081481"; MUTAGEN 266; /note="C->S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression."; /evidence="ECO:0000269|PubMed:12081481"; MUTAGEN 288; /note="C->A,G,R: No loss of calcium flux but loss of chemotaxis in response to CCL20 stimulation. No effect on cell surface expression."; /evidence="ECO:0000269|PubMed:12081481"; MUTAGEN 288; /note="C->S: No loss of calcium flux but loss of chemotaxis in response to CCL20 stimulation, impaired CCL20-binding and no effect on cell surface expression; when associated with or without S-36. Loss of calcium flux in response to CCL20 stimulation and significant reduction in cell surface expression; when associated with S-36; S-118 and S-197."; /evidence="ECO:0000269|PubMed:12081481"; MUTAGEN 309; /note="C->S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression."; /evidence="ECO:0000269|PubMed:12081481"; MUTAGEN 310; /note="C->S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression."; /evidence="ECO:0000269|PubMed:12081481"; MUTAGEN 336; /note="C->S: Reduced calcium flux and chemotaxis in response to CCL20 stimulation, and reduced CCL20-binding. No effect on cell surface expression."; /evidence="ECO:0000269|PubMed:12081481"; MUTAGEN 348; /note="C->S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on CCL20-binding and cell surface expression."; /evidence="ECO:0000269|PubMed:12081481
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12081481
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20068036
uniprot
proteins
pubmed
21376174
uniprot
proteins
pubmed
23765988
uniprot
proteins
pubmed
25122636
uniprot
proteins
pubmed
25585877
uniprot
proteins
pubmed
8886020
uniprot
proteins
pubmed
9070937
uniprot
proteins
pubmed
9169459
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23765988}; Multi-pass membrane protein {ECO:0000255}. Cell surface {ECO:0000269|PubMed:12081481}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..74; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 120..141; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 212..238; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 255..279; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 304..321; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins