Auh
entrez
11992
canonical
uniprot
Q9JLZ3
canonical
ensembl
ENSMUSG00000021460
resolver
ensp
ENSMUSP00000021913
resolver
ensp
ENSMUSP00000105658
resolver
ensp
ENSMUSP00000167772
resolver
ensp
ENSMUSP00000167773
resolver
ensp
ENSMUSP00000167774
resolver
ensp
ENSMUSP00000167776
resolver
ensp
ENSMUSP00000167779
resolver
ensp
ENSMUSP00000167782
resolver
ensp
ENSMUSP00000167783
resolver
ensp
ENSMUSP00000167790
resolver
ensp
ENSMUSP00000167791
resolver
ensp
ENSMUSP00000167792
resolver
ensp
ENSMUSP00000167815
resolver
ensp
ENSMUSP00000167817
resolver
enst
ENSMUST00000021913
resolver
enst
ENSMUST00000110031
resolver
genesymbol
Auh
resolver
uniprot
A0A0R4J023
resolver
uniprot
E9QMT1
resolver
uniprot
Q80YD7
resolver
uniprot
Q8QZS0
resolver
uniprot
Q9CY78
resolver
uniprot
Q9D155
resolver
uniprot_entry
A0A0R4J023_MOUSE
resolver
uniprot_entry
AUHM_MOUSE
resolver
uniprot_entry
E9QMT1_MOUSE
resolver
uniprot_sec
Q80YD7
resolver
uniprot_sec
Q8QZS0
resolver
uniprot_sec
Q9CY78
resolver
uniprot_sec
Q9D155
resolver
amino_acid_sequence
MAAAAPGALGALRTGRVRLVAACCARLGPAAWARGTAPRRGYSSEVKTEDELRVRHLEEENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSEVGPFVSKIRSVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGQEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLEGLLAFKEKRPPRYKGE
uniprot
proteins
ec_number
4.2.1.18
uniprot
proteins
ec_number
4.2.1.56
uniprot
proteins
function
FUNCTION: Catalyzes the fifth step in the leucine degradation pathway, the reversible hydration of 3-methylglutaconyl-CoA (3-MG-CoA) to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Can catalyze the reverse reaction but at a much lower rate in vitro. HMG-CoA is then quickly degraded by another enzyme (such as HMG-CoA lyase) to give acetyl-CoA and acetoacetate. Uses other substrates such as (2E)-glutaconyl-CoA efficiently in vitro, and to a lesser extent 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA), crotonyl-CoA ((2E)-butenoyl-CoA) and 3-hydroxybutanoyl-CoA (the missing carboxylate reduces affinity to the active site) (By similarity). Originally it was identified as an RNA-binding protein as it binds to AU-rich elements (AREs) in vitro. AREs direct rapid RNA degradation and mRNA deadenylation (PubMed:10072761). Might have itaconyl-CoA hydratase activity, converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, an antimicrobial metabolite and immunomodulator produced by macrophages during certain infections, that can act as a vitamin B12-poisoning metabolite (By similarity). {ECO:0000250|UniProtKB:Q13825, ECO:0000269|PubMed:10072761}.
uniprot
proteins
mass_dalton
33395
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 3/3. {ECO:0000250|UniProtKB:Q13825}.
uniprot
proteins
protein_family
Enoyl-CoA hydratase/isomerase family
uniprot
proteins
pubmed
10072761
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10072761}.
uniprot
proteins