FKBP5
entrez
2289
canonical
uniprot
Q13451
canonical
ensembl
ENSG00000096060
resolver
ensp
ENSP00000349811
resolver
ensp
ENSP00000441205
resolver
ensp
ENSP00000442340
resolver
ensp
ENSP00000444810
resolver
genesymbol
FKBP5
resolver
genesymbol_syn
AIG6
resolver
genesymbol_syn
FKBP51
resolver
hgnc
HGNC:3721
resolver
uniprot
F5H7R1
resolver
uniprot
Q2TA84
resolver
uniprot
Q59EB8
resolver
uniprot
Q5TGM6
resolver
uniprot_entry
FKBP5_HUMAN
resolver
uniprot_entry
Q2TA84_HUMAN
resolver
uniprot_sec
F5H7R1
resolver
uniprot_sec
Q59EB8
resolver
uniprot_sec
Q5TGM6
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by both FK506 and rapamycin. {ECO:0000250|UniProtKB:Q64378}.
uniprot
proteins
amino_acid_sequence
MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGEDLFEDGGIIRRTKRKGEGYSNPNEGATVEIHLEGRCGGRMFDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKTSEGVTNEKGTDSQAMEEEKPEGHV
uniprot
proteins
ec_number
5.2.1.8
uniprot
proteins
function
FUNCTION: Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277, PubMed:28363942). Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production (PubMed:26101251, PubMed:31434731). {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:12538866, ECO:0000269|PubMed:26101251, ECO:0000269|PubMed:28147277, ECO:0000269|PubMed:28363942, ECO:0000269|PubMed:31434731}.
uniprot
proteins
mass_dalton
51212
uniprot
proteins
mutagenesis
MUTAGEN 28; /note="K->Q: Mimics acetylation; impaired interaction with AKT1 and PHLPP1; when associated with Q-155."; /evidence="ECO:0000269|PubMed:28147277"; MUTAGEN 28; /note="K->R: Decreased acetylation; promotes interaction with AKT1 and PHLPP1; when associated with R-155."; /evidence="ECO:0000269|PubMed:28147277"; MUTAGEN 155; /note="K->Q: Mimics acetylation; impaired interaction with AKT1 and PHLPP1; when associated with Q-28."; /evidence="ECO:0000269|PubMed:28147277"; MUTAGEN 155; /note="K->R: Decreased acetylation; promotes interaction with AKT1 and PHLPP1; when associated with R-28."; /evidence="ECO:0000269|PubMed:28147277
uniprot
proteins
post_translational_modification
PTM: Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1 (PubMed:28147277). Deacetylation by SIRT7 promotes interaction between Akt/AKT1 and PHLPP1, leading to suppress Akt/AKT1 activation (PubMed:28147277). {ECO:0000269|PubMed:28147277}.; PTM: Ubiquitinated, leading to degradation in a proteasome-dependent manner. Deubiquitinated by USP49, leading to stabilization. {ECO:0000269|PubMed:28363942}.
uniprot
proteins
pubmed
11350175
uniprot
proteins
pubmed
12538866
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26101251
uniprot
proteins
pubmed
28147277
uniprot
proteins
pubmed
28363942
uniprot
proteins
pubmed
31434731
uniprot
proteins
pubmed
7693698
uniprot
proteins
pubmed
9001212
uniprot
proteins
pubmed
9125197
uniprot
proteins
sequence_length
457
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q64378}. Nucleus {ECO:0000250|UniProtKB:Q64378}.
uniprot
proteins