KLK14
entrez
43847
canonical
uniprot
Q9P0G3
canonical
ensembl
ENSG00000129437
resolver
ensp
ENSP00000156499
resolver
ensp
ENSP00000375678
resolver
ensp
ENSP00000497141
resolver
ensp
ENSP00000529028
resolver
ensp
ENSP00000594559
resolver
enst
ENST00000156499
resolver
enst
ENST00000391802
resolver
enst
ENST00000650543
resolver
enst
ENST00000858969
resolver
enst
ENST00000924500
resolver
genesymbol
KLK14
resolver
genesymbol_syn
KLKL6
resolver
hgnc
HGNC:6362
resolver
uniprot
A0A1R3UHJ7
resolver
uniprot
A7UNK5
resolver
uniprot
Q1RMZ2
resolver
uniprot
Q6B089
resolver
uniprot_entry
KLK14_HUMAN
resolver
uniprot_sec
A0A1R3UHJ7
resolver
uniprot_sec
A7UNK5
resolver
uniprot_sec
Q1RMZ2
resolver
uniprot_sec
Q6B089
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by SERPINA1, SERPINC1, SERPINE1, SERPINF2, aprotinin, soybean, trypsin inhibitor and leupeptin. Inhibited by serine protease inhibitor SPINK5. Has an autoproteolytic activity which may have a regulatory effect. Activated by citrate and inhibited by zinc and to a lower extent by manganese. {ECO:0000269|PubMed:15654974, ECO:0000269|PubMed:17110383, ECO:0000269|PubMed:17158887}.
uniprot
proteins
amino_acid_sequence
MFLLLTALQVLAIAMTQSQEDENKIIGGHTCTRSSQPWQAALLAGPRRRFLCGGALLSGQWVITAAHCGRPILQVALGKHNLRRWEATQQVLRVVRQVTHPNYNSRTHDNDLMLLQLQQPARIGRAVRPIEVTQACASPGTSCRVSGWGTISSPIARYPASLQCVNINISPDEVCQKAYPRTITPGMVCAGVPQGGKDSCQGDSGGPLVCRGQLQGLVSWGMERCALPGYPGVYTNLCKYRSWIEETMRDK
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. {ECO:0000269|PubMed:15654974, ECO:0000269|PubMed:16885167, ECO:0000269|PubMed:17158887, ECO:0000269|PubMed:17625593, ECO:0000269|PubMed:18056261, ECO:0000269|PubMed:18482984}.
uniprot
proteins
mass_dalton
27453
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage of the activation peptide produces the active enzyme. {ECO:0000269|PubMed:17110383}.
uniprot
proteins
protein_family
Kallikrein subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10969073
uniprot
proteins
pubmed
11309303
uniprot
proteins
pubmed
11352573
uniprot
proteins
pubmed
12645335
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15654974
uniprot
proteins
pubmed
15843175
uniprot
proteins
pubmed
16456535
uniprot
proteins
pubmed
16800737
uniprot
proteins
pubmed
16885167
uniprot
proteins
pubmed
17110383
uniprot
proteins
pubmed
17158887
uniprot
proteins
pubmed
17625593
uniprot
proteins
pubmed
17922479
uniprot
proteins
pubmed
18056261
uniprot
proteins
pubmed
18482984
uniprot
proteins
pubmed
28224083
uniprot
proteins
sequence_length
251
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:15654974, ECO:0000269|PubMed:16456535, ECO:0000269|PubMed:17110383}.
uniprot
proteins