DPF3
entrez
8110
canonical
uniprot
Q92784
canonical
ensembl
ENSG00000205683
resolver
ensp
ENSP00000370614
resolver
ensp
ENSP00000381791
resolver
ensp
ENSP00000450518
resolver
ensp
ENSP00000481992
resolver
enst
ENST00000366353
resolver
genesymbol
DPF3
resolver
genesymbol_syn
BAF45C
resolver
genesymbol_syn
CERD4
resolver
hgnc
HGNC:17427
resolver
uniprot
A8MSI3
resolver
uniprot
B7Z276
resolver
uniprot
F5H575
resolver
uniprot
F8W7T1
resolver
uniprot
Q32UJ0
resolver
uniprot
Q6P9E6
resolver
uniprot
Q6ZT41
resolver
uniprot
Q9H7Y5
resolver
uniprot_entry
DPF3_HUMAN
resolver
uniprot_entry
F8W7T1_HUMAN
resolver
uniprot_sec
A8MSI3
resolver
uniprot_sec
B7Z276
resolver
uniprot_sec
F5H575
resolver
uniprot_sec
Q32UJ0
resolver
uniprot_sec
Q6P9E6
resolver
uniprot_sec
Q6ZT41
resolver
uniprot_sec
Q9H7Y5
resolver
amino_acid_sequence
MATVIHNPLKALGDQFYKEAIEHCRSYNSRLCAERSVRLPFLDSQTGVAQNNCYIWMEKRHRGPGLAPGQLYTYPARCWRKKRRLHPPEDPKLRLLEIKPEVELPLKKDGFTSESTTLEALLRGEGVEKKVDAREEESIQEIQRVLENDENVEEGNEEEDLEEDIPKRKNRTRGRARGSAGGRRRHDAASQEDHDKPYVCDICGKRYKNRPGLSYHYAHTHLASEEGDEAQDQETRSPPNHRNENHRPQKGPDGTVIPNNYCDFCLGGSNMNKKSGRPEELVSCADCGRSGHPTCLQFTLNMTEAVKTYKWQCIECKSCILCGTSENDDQLLFCDDCDRGYHMYCLNPPVAEPPEGSWSCHLCWELLKEKASAFGCQA
uniprot
proteins
function
FUNCTION: Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development. {ECO:0000250, ECO:0000269|PubMed:18765789}.; FUNCTION: [Isoform 2]: Acts as a regulator of myogenesis in cooperation with HDGFL2 (PubMed:32459350). Mediates the interaction of HDGFL2 with the BAF complex (PubMed:32459350). HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). {ECO:0000269|PubMed:32459350}.
uniprot
proteins
mass_dalton
43084
uniprot
proteins
mutagenesis
MUTAGEN 358; /note="W->E: Abolishes binding to acetylated histones H3 and H4."; /evidence="ECO:0000269|PubMed:18765789"; MUTAGEN 360; /note="C->R: Abolishes binding to acetylated histones H3 and H4; when associated with R-363."; /evidence="ECO:0000269|PubMed:18765789"; MUTAGEN 363; /note="C->R: Abolishes binding to acetylated histones H3 and H4; when associated with R-360."; /evidence="ECO:0000269|PubMed:18765789"; MUTAGEN Q92784-2:323; /note="S->A: Phosphorylation-null mutant. Loss of interaction with HDGFL2."; /evidence="ECO:0000269|PubMed:32459350"; MUTAGEN Q92784-2:323; /note="S->D,E: Phosphomimetic mutant. Increased interaction with HDGFL2."; /evidence="ECO:0000269|PubMed:32459350"; MUTAGEN Q92784-2:325; /note="F->A: Loss of interaction with HDGFL2. No effect on interaction with SMARCA4, SMARCC1 and SMARCD1."; /evidence="ECO:0000269|PubMed:32459350"; MUTAGEN Q92784-2:328; /note="F->A: Loss of interaction with HDGFL2. No effect on interaction with SMARCA4, SMARCC1 and SMARCD1."; /evidence="ECO:0000269|PubMed:32459350
uniprot
proteins
post_translational_modification
PTM: [Isoform 2]: Phosphorylation at Ser-323 enhances its interaction with HDGFL2. {ECO:0000269|PubMed:32459350}.
uniprot
proteins
protein_family
Requiem/DPF family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18765789
uniprot
proteins
pubmed
20613843
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
32459350
uniprot
proteins
pubmed
8812431
uniprot
proteins
sequence_length
378
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins