TRAPPC14
entrez
55262
canonical
uniprot
Q8WVR3
canonical
ensembl
ENSG00000146826
resolver
ensp
ENSP00000324741
resolver
ensp
ENSP00000389672
resolver
ensp
ENSP00000396432
resolver
enst
ENST00000456769
resolver
enst
ENST00000457641
resolver
genesymbol
TRAPPC14
resolver
genesymbol_syn
C7orf43
resolver
genesymbol_syn
MAP11
resolver
hgnc
HGNC:25604
resolver
uniprot
A0ACM8QG86
resolver
uniprot
A4D2A9
resolver
uniprot
B3KNS5
resolver
uniprot
D6W5U4
resolver
uniprot
H0Y452
resolver
uniprot
Q9BQJ1
resolver
uniprot
Q9BUB6
resolver
uniprot
Q9NV47
resolver
uniprot_entry
A0ACM8QG86_HUMAN
resolver
uniprot_entry
B3KNS5_HUMAN
resolver
uniprot_entry
TPC14_HUMAN
resolver
uniprot_sec
A4D2A9
resolver
uniprot_sec
D6W5U4
resolver
uniprot_sec
H0Y452
resolver
uniprot_sec
Q9BQJ1
resolver
uniprot_sec
Q9BUB6
resolver
uniprot_sec
Q9NV47
resolver
amino_acid_sequence
MESQCDYSMYFPAVPLPPRAELAGDPGRYRALPRRNHLYLGETVRFLLVLRCRGGAGSGTGGGPGLGSRGAWAELATALAALASVSAGGGMPGGGGAGDQDSEPPGGGDPGGGGLFRGCSPLLTHGPGPATSGGATTLPVEEPIVSTDEVIFPLTVSLDRLPPGTPKAKIVVTVWKREIEAPEVRDQGYLRLLQTRSPGETFRGEQSAFKAQVSTLLTLLPPPVLRCRQFTVAGKHLTVLKVLNSSSQEEISIWDIRILPNFNASYLPVMPDGSVLLVDNVCHQSGEVSMGSFCRLPGTSGCFPCPLNALEEHNFLFQLRGGEQPPPGAKEGLEVPLIAVVQWSTPKLPFTQSIYTHYRLPSVRLDRPCFVMTASCKSPVRTYERFTVTYTLLNNLQDFLAVRLVWTPEHAQAGKQLCEEERRAMQAALDSVVCHTPLNNLGFSRKGSALTFSVAFQALRTGLFELSQHMKLKLQFTASVSHPPPEARPLSRKSSPSSPAVRDLVERHQASLGRSQSFSHQQPSRSHLMRSGSVMERRAITPPVASPVGRPLYLPPDKAVLSLDKIAKRECKVLVVEPVK
uniprot
proteins
disease_involvement
DISEASE: Microcephaly 25, primary, autosomal recessive (MCPH25) [MIM:618351]: A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH25 patients additionally manifest global developmental delay, severe intellectual disability with speech impairment, attention deficit-hyperactivity disorder, and reduced white matter and thin corpus callosum on brain imaging. {ECO:0000269|PubMed:30715179}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether (PubMed:30715179, PubMed:31467083). TRAPP II complex also has GEF activity toward RAB1A (By similarity). TRAPPC14 is dispensable for TRAPPII complex integrity but mediates RAB3IP preciliary vesicle trafficking to the mother centriole during ciliogenesis (PubMed:31467083). Modulates YAP1 activity as transcriptional regulator (PubMed:30447097). {ECO:0000250|UniProtKB:Q3TLI0, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:30715179, ECO:0000269|PubMed:31467083}.
uniprot
proteins
mass_dalton
62597
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30447097
uniprot
proteins
pubmed
30715179
uniprot
proteins
pubmed
31467083
uniprot
proteins
sequence_length
580
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:30715179}. Vesicle {ECO:0000269|PubMed:30715179, ECO:0000269|PubMed:31467083}. Midbody {ECO:0000269|PubMed:30715179}. Cytoplasm {ECO:0000269|PubMed:31467083}. Note=During mitosis, precedes alpha-tubulin in gap formation of cell abscission at the midbody and is co-localized with PLK1 at the edges of microtubules extensions of daughter cells post cytokinesis abscission (PubMed:30715179). Colocalizes with RAB3IP on preciliary vesicles (PubMed:31467083). {ECO:0000269|PubMed:30715179, ECO:0000269|PubMed:31467083}.
uniprot
proteins