Nudt12
entrez
67993
canonical
uniprot
Q9DCN1
canonical
ensembl
ENSMUSG00000024228
resolver
ensp
ENSMUSP00000025065
resolver
ensp
ENSMUSP00000195046
resolver
genesymbol
Nudt12
resolver
uniprot
Q6PFA5
resolver
uniprot_entry
NUD12_MOUSE
resolver
uniprot_sec
Q6PFA5
resolver
amino_acid_sequence
MSSVKRNPKKEMISELHSSAAEGNVAKLAGILSHSPSLLNETSENGWTALMYAARNGHPDVVQFLLEKGCDRSLVNKARQTALDIAAFWGYRHIANLLANAKGGKKPWFLTNEVDECENYFSRTLLDRRSDKRNNSDWLQAKESHPTTVYLLFSDLNPLVTLGGNKESSQQPEVRLCQLNYPDVKGYLAQPEKITLVFLGVELEMRKGSPAQAGGVPEEEEDGLVAWFALGIEPGAAEEFKQRHENCYFLHPPMPALLQLKEKEAGVVAQARSVLAWHSRYKFCPTCGSATKIEEGGYKRVCVRETCPSLQGVHNTSYPRVDPVVIMQVIHPDGTKCLLGRQKRFPPGMFTCLAGFIEPGETIEDAVRREVEEESGVKVGHVQYVSCQPWPMPSSLMIGCLAVAVSTEIKVDKNEIEDARWFTREQVVDVLTKGKQQAFFVPPSRAIAHQLIKHWVGMNPNL
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
ec_number
3.6.1.22
uniprot
proteins
function
FUNCTION: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA (PubMed:31101919, PubMed:32432673). The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:31101919). Preferentially acts on NAD-capped transcripts in response to nutrient stress (PubMed:31101919). Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP (By similarity). May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (By similarity). Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (PubMed:31875550). {ECO:0000250|UniProtKB:Q9BQG2, ECO:0000269|PubMed:31101919, ECO:0000269|PubMed:31875550}.
uniprot
proteins
mass_dalton
51511
uniprot
proteins
mutagenesis
MUTAGEN 373..374; /note="EE->QQ: Abolished deNADding activity."; /evidence="ECO:0000269|PubMed:31101919
uniprot
proteins
protein_family
NudC subfamily
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
31101919
uniprot
proteins
pubmed
31875550
uniprot
proteins
pubmed
32432673
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BQG2}. Peroxisome {ECO:0000250|UniProtKB:Q9BQG2}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q9BQG2}. Note=Localizes to cytoplasmic granules in the presence of BLMH. {ECO:0000250|UniProtKB:Q9BQG2}.
uniprot
proteins