Aup1
entrez
680423
canonical
uniprot
A1L134
canonical
ensembl
ENSRNOG00000007842
resolver
ensp
ENSRNOP00000010602
resolver
ensp
ENSRNOP00000077286
resolver
enst
ENSRNOT00000010602
resolver
genesymbol
Aup1
resolver
uniprot
A0A8L2Q4W6
resolver
uniprot_entry
A0A8L2Q4W6_RAT
resolver
uniprot_entry
AUP1_RAT
resolver
amino_acid_sequence
MEPPPAPGPERLFDSHRLPSDGFLLLALLLYAPVGLCLLVLRLFLGLHVFLVSCALPDSVLRRFVVRTMCAVLGLVARQEDSGLRDHRVRVLISNHVTPFDHNIVNLLTTCSTPLLNSPPSFVCWSRGFMEMDRRVELVESLKKFCASTRLPPTPLLLFPEEEATNGREGLLRFSSWPFSIQDVVQPLTLQVQRPLVSVTVSDASWVSELLWSLFVPFTVYQVRWLHPIRRQLGEENEEFALRVQQLVAKELGQIGTRLTPADKAEHMKRQRHPRLRPQSVQSSFPSPPSPSSDVQLTILAQRVKEVLPHVPLNVIQRDLARTGCVDLTITNLLEGAVAFMPEDVTEGSQSLPTASAPKFPSSGLVTPQPTALTFAKSSWARQESLQERKQALYEYARRRFRERQAQEAE
uniprot
proteins
function
FUNCTION: Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (By similarity). Plays a role in lipid droplet formation (By similarity). Induces lipid droplet clustering (By similarity). Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (By similarity). Also required for the degradation of INSIG1, SREBF1 and SREBF2 (By similarity). Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB (By similarity). {ECO:0000250|UniProtKB:Q9Y679}.
uniprot
proteins
mass_dalton
46199
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated and diubiquitinated. {ECO:0000250|UniProtKB:Q9Y679}.
uniprot
proteins
protein_family
AUP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y679}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Y679}. Lipid droplet {ECO:0000250|UniProtKB:Q9Y679}.
uniprot
proteins