Pa2g4
entrez
18813
canonical
uniprot
P50580
canonical
ensembl
ENSMUSG00000025364
resolver
ensp
ENSMUSP00000026425
resolver
genesymbol
Pa2g4
resolver
genesymbol_syn
Ebp1
resolver
genesymbol_syn
Plfap
resolver
uniprot
D3YVH7
resolver
uniprot
Q3TGU7
resolver
uniprot_entry
PA2G4_MOUSE
resolver
uniprot_entry
Q3TGU7_MOUSE
resolver
uniprot_sec
D3YVH7
resolver
amino_acid_sequence
MSGEDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTVENATSGETLEENGAGD
uniprot
proteins
function
FUNCTION: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly (By similarity). Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Together with PTBP1 is required for the translation initiation on the foot-and-mouth disease virus (FMDV) IRES. Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:Q6AYD3, ECO:0000250|UniProtKB:Q9UQ80, ECO:0000269|PubMed:10950867, ECO:0000269|PubMed:17690690}.
uniprot
proteins
mass_dalton
43699
uniprot
proteins
mutagenesis
MUTAGEN 65..72; /note="KKEKEMKK->SSSSSSSS: No effect on RNA-binding."; /evidence="ECO:0000269|PubMed:17690690
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues. Phosphorylation is enhanced by HRG treatment. Basal phosphorylation is PKC-dependent and HRG-induced phosphorylation is predominantly PKC-independent. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. {ECO:0000250|UniProtKB:Q9UQ80}.; PTM: Isoform 2 is polyubiquitinated, leading to proteasomal degradation and phosphorylation by PKC/PRKCD enhances polyubiquitination. {ECO:0000250|UniProtKB:Q9UQ80}.
uniprot
proteins
protein_family
Peptidase M24 family
uniprot
proteins
pubmed
10950867
uniprot
proteins
pubmed
15064750
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17690690
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7556453
uniprot
proteins
pubmed
9284967
uniprot
proteins
sequence_length
394
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:Q9UQ80}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9UQ80}. Note=Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. {ECO:0000250|UniProtKB:Q9UQ80}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:7556453}.
uniprot
proteins