Fbxo46
entrez
292686
canonical
uniprot
Q4KLY2
canonical
ensembl
ENSRNOG00000008815
resolver
ensembl
ENSRNOG00055032700
resolver
ensembl
ENSRNOG00060032908
resolver
ensembl
ENSRNOG00065033951
resolver
ensp
ENSRNOP00000012082
resolver
ensp
ENSRNOP00000079832
resolver
ensp
ENSRNOP00000090659
resolver
ensp
ENSRNOP00000097011
resolver
ensp
ENSRNOP00000099991
resolver
ensp
ENSRNOP00000103091
resolver
ensp
ENSRNOP00000103398
resolver
ensp
ENSRNOP00000104645
resolver
ensp
ENSRNOP00000104882
resolver
ensp
ENSRNOP00000112051
resolver
ensp
ENSRNOP00055046613
resolver
ensp
ENSRNOP00055046616
resolver
ensp
ENSRNOP00055046617
resolver
ensp
ENSRNOP00055046619
resolver
ensp
ENSRNOP00055046621
resolver
ensp
ENSRNOP00060047128
resolver
ensp
ENSRNOP00060047129
resolver
ensp
ENSRNOP00060047131
resolver
ensp
ENSRNOP00060047132
resolver
ensp
ENSRNOP00060047134
resolver
ensp
ENSRNOP00065047983
resolver
ensp
ENSRNOP00065047984
resolver
ensp
ENSRNOP00065047985
resolver
ensp
ENSRNOP00065047987
resolver
ensp
ENSRNOP00065047988
resolver
enst
ENSRNOT00000012082
resolver
enst
ENSRNOT00000115550
resolver
enst
ENSRNOT00000118710
resolver
enst
ENSRNOT00000119270
resolver
enst
ENSRNOT00000122695
resolver
enst
ENSRNOT00000139630
resolver
enst
ENSRNOT00000155506
resolver
enst
ENSRNOT00000162291
resolver
enst
ENSRNOT00000166640
resolver
enst
ENSRNOT00000171860
resolver
enst
ENSRNOT00055056507
resolver
enst
ENSRNOT00055056510
resolver
enst
ENSRNOT00055056511
resolver
enst
ENSRNOT00055056513
resolver
enst
ENSRNOT00055056515
resolver
enst
ENSRNOT00060057048
resolver
enst
ENSRNOT00060057049
resolver
enst
ENSRNOT00060057051
resolver
enst
ENSRNOT00060057052
resolver
enst
ENSRNOT00060057054
resolver
enst
ENSRNOT00065058307
resolver
enst
ENSRNOT00065058308
resolver
enst
ENSRNOT00065058309
resolver
enst
ENSRNOT00065058311
resolver
enst
ENSRNOT00065058312
resolver
genesymbol
Fbxo46
resolver
uniprot_entry
FBX46_RAT
resolver
amino_acid_sequence
MDRGSLLPFQLWCPRPFSKYSQNQPRPPSATLKPPVCPDTSSGTEPDHRPAHLESTPPALAAEAPTSQHAPLLSTAASGDEGRVLLDTWYVIKPGNTKEKVAFFVAHQCGGGSRASSMKVKGHWGSDSSKAKRRRRCLEPTKAPPDQGGQEGTPATEVAPTSSGDDVDLLSVAEMVALVEQRAALALQSYPRPSTPAPVVFVSAEQGGPAKGLGSERRSGGGDCSRVAEAVAHFEAQRDSPPTKGLRKEERPGPGPGEVRIAFRISNVREPQSPDGSLANGGGGRPACPYPGSPGPGTRAKDKITCDLYQLISPSRDALPSNVEFLLARADEASEGETPAPARPEDTPPAPPPPPARDCGASGFHVDVVVTGVVDACIFFGKDGTKNVKEETVCLTVSPEEPPPPGQLFFLQSRGPEGPPEPPPADTASKVPGPEDSEGTTDTSLCRLYRHVSHDFLEIRFKIQRLLEPRQYMLLLPEHVLVKIFSFLPTRALAALKCTCHHFKGIIEAFGVRATDSRWSRDPLYRDDPCKQCRKRYEKGDVSLCRWHPKPYHHDLPYGRSYWMCCRRADRETPGCRLGLHDNNWVLPCNGVGGGRAGREEGR
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins. In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31. {ECO:0000250|UniProtKB:Q6PJ61}.
uniprot
proteins
mass_dalton
65239
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q6PJ61}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ATM in response to DNA damage, promoting ubiquitination and degradation by the SCF(FBXO31) complex. {ECO:0000250|UniProtKB:Q6PJ61}.; PTM: ATM-phosphorylated FBXO46 is ubiquitinated and degradaded by the SCF(FBXO31) complex in response to DNA damage. {ECO:0000250|UniProtKB:Q6PJ61}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
603
uniprot
proteins