Il1r2
entrez
117022
canonical
uniprot
P43303
canonical
ensembl
ENSRNOG00000014378
resolver
ensp
ENSRNOP00000019415
resolver
genesymbol
Il1r2
resolver
genesymbol_syn
Il-1r2
resolver
genesymbol_syn
Il1rb
resolver
uniprot
Q5BJ99
resolver
uniprot_entry
IL1R2_RAT
resolver
uniprot_sec
Q5BJ99
resolver
amino_acid_sequence
MFILLVLVTGVSAFTTPAVVHTGRVSESPVTSEKHPVLGDDCWFRGRDFKSELRLEGEPVVLRCPLVPHSDTSSSSRSLLTWSKSDSSQLIPGDEPRMWVKDDTLWVLPAVQQDSGTYICTFRNASHCEQMSLELKVFKNTEASFPLVSYLQISALSSTGLLVCPDLKEFISSRTDGKIQWYKGSILLDKGNKKFLSAGDPTRLLISNTSMGDAGYYRCVMTFTYEGKEYNITRNIELRVKGITTEPIPVIISPLETIPASLGSRLIVPCKVFLGTGTSSNTIVWWMANSTFISVAYPRGRVTEGLHHQYSENDENYVEVSLIFDPVTKEDLNTDFKCVATNPRSFQSLHTTVKEVSSTFSWGIALAPLSLIILVVGAIWIRRRCKRQAGKTYGLTKLPTDNQDFPSSPNQIKEMK
uniprot
proteins
function
FUNCTION: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
46353
uniprot
proteins
post_translational_modification
PTM: A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase. {ECO:0000250}.
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7524717
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000250}. Secreted {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 356..381; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins