Ccn3
entrez
81526
canonical
uniprot
Q9QZQ5
canonical
ensembl
ENSRNOG00055021821
resolver
ensembl
ENSRNOG00060003150
resolver
ensembl
ENSRNOG00065014985
resolver
ensp
ENSRNOP00055030497
resolver
ensp
ENSRNOP00060003814
resolver
ensp
ENSRNOP00065019380
resolver
enst
ENSRNOT00055037413
resolver
enst
ENSRNOT00060005178
resolver
enst
ENSRNOT00065024797
resolver
genesymbol
Ccn3
resolver
genesymbol_syn
Nov
resolver
uniprot_entry
CCN3_RAT
resolver
amino_acid_sequence
MSVFLRKQCLCLGFLLLHLLNQVSATLRCPSRCPSQCPSISPTCAPGVRSVLDGCSCCPVCARQRGESCSEMRPCDQSSGLYCDRSADPNNETGICMVPEGDNCVFDGVIYRNGEKFEPNCQYHCTCRDGQIGCVPRCQLDVLLPGPDCPAPKKVAVPGECCEKWTCGSEEKGTLGGLALPAYRPEATVGVELSDSSINCIEQTTEWSACSKSCGMGLSTRVTNRNLQCEMVKQTRLCMVRPCEQEPGEATDMKGKKCLRTKKSLKSIHLQFKNCTSLYTYKPRFCGICSDGRCCTPFNTKTIQVEFQCLPGQIIKKPVMVIGTCTCHSNCPQNNEAFLQELELKTSRGEM
uniprot
proteins
function
FUNCTION: Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. Essential regulator of hematopoietic stem and progenitor cell function. Inhibits myogenic differentiation through the activation of Notch-signaling pathway. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling. Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival. Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (By similarity). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (By similarity). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:22353423). Brain osteoanabolic hormone. During lactation, maintains the maternal skeleton and viability of offspring (By similarity). {ECO:0000250|UniProtKB:P48745, ECO:0000250|UniProtKB:Q64299, ECO:0000269|PubMed:21871891, ECO:0000269|PubMed:22353423}.
uniprot
proteins
mass_dalton
38510
uniprot
proteins
post_translational_modification
PTM: May be palmitoylated on Cys-238, which is important for extracellular secretion. {ECO:0000250|UniProtKB:Q64299}.
uniprot
proteins
protein_family
CCN family
uniprot
proteins
pubmed
10570975
uniprot
proteins
pubmed
15181016
uniprot
proteins
pubmed
15213231
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21871891
uniprot
proteins
pubmed
22353423
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15213231}. Cytoplasm {ECO:0000269|PubMed:15213231, ECO:0000269|PubMed:22353423}. Cell junction, gap junction {ECO:0000269|PubMed:15213231}. Note=Localizes at the gap junction in presence of GJA1. {ECO:0000269|PubMed:15213231}.
uniprot
proteins