Ada
entrez
11486
canonical
uniprot
P03958
canonical
ensembl
ENSMUSG00000017697
resolver
ensp
ENSMUSP00000017841
resolver
ensp
ENSMUSP00000294010
resolver
enst
ENSMUST00000017841
resolver
genesymbol
Ada
resolver
uniprot
Q4FK28
resolver
uniprot_entry
ADA_MOUSE
resolver
uniprot_entry
Q4FK28_MOUSE
resolver
amino_acid_sequence
MAQTPAFNKPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVDPMPWNQTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQPSWSLEVLELCKKYNQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNINAAKSSFLPEEEKKELLERLYREYQ
uniprot
proteins
ec_number
3.5.4.4
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:10720488, PubMed:8634299, PubMed:8672487, PubMed:8942668, PubMed:9272950). Plays an important role in purine metabolism and in adenosine homeostasis (PubMed:10720488, PubMed:9272950). Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (PubMed:11435465). Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (By similarity). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (By similarity). Stimulates plasminogen activation (By similarity). Plays a role in male fertility (By similarity). Plays a protective role in early postimplantation embryonic development (PubMed:9272950). Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties (PubMed:26038697). {ECO:0000250|UniProtKB:P00813, ECO:0000250|UniProtKB:P56658, ECO:0000269|PubMed:10720488, ECO:0000269|PubMed:11435465, ECO:0000269|PubMed:26038697, ECO:0000269|PubMed:8634299, ECO:0000269|PubMed:8672487, ECO:0000269|PubMed:8942668, ECO:0000269|PubMed:9272950}.
uniprot
proteins
mass_dalton
39992
uniprot
proteins
mutagenesis
MUTAGEN 217; /note="E->D: Reduces catalytic activity 700-fold. No effect on affinity for adenosine."; /evidence="ECO:0000269|PubMed:8634299"; MUTAGEN 217; /note="E->G: Reduces catalytic activity 3200-fold. No effect on affinity for adenosine."; /evidence="ECO:0000269|PubMed:8634299"; MUTAGEN 217; /note="E->Q: Reduces catalytic activity 4800-fold, and slightly increases affinity for substrate."; /evidence="ECO:0000269|PubMed:8634299"; MUTAGEN 217; /note="E->S: Loss of activity."; /evidence="ECO:0000269|PubMed:8634299"; MUTAGEN 238; /note="H->A: Increases affinity for adenosine 20-fold. Reduces enzyme activity 500-fold."; /evidence="ECO:0000269|PubMed:8942668"; MUTAGEN 238; /note="H->E: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:8942668"; MUTAGEN 238; /note="H->R: Reduces enzyme activity 1500-fold. No effect on affinity for adenosine."; /evidence="ECO:0000269|PubMed:8942668"; MUTAGEN 295; /note="D->E: No effect on affinity for adenosine. Reduces enzyme activity 2750-fold."; /evidence="ECO:0000269|PubMed:8672487"; MUTAGEN 296; /note="D->A: Reduces affinity for adenosine 70-fold. Reduces enzyme activity 110000-fold."; /evidence="ECO:0000269|PubMed:8672487"; MUTAGEN 296; /note="D->N: Reduces affinity for adenosine 10-fold. Reduces enzyme activity 100-fold."; /evidence="ECO:0000269|PubMed:8672487
uniprot
proteins
protein_family
Adenosine and AMP deaminases family
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
pubmed
10720488
uniprot
proteins
pubmed
10899903
uniprot
proteins
pubmed
11435465
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1925539
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2387582
uniprot
proteins
pubmed
2410423
uniprot
proteins
pubmed
26038697
uniprot
proteins
pubmed
7670465
uniprot
proteins
pubmed
7731963
uniprot
proteins
pubmed
8634299
uniprot
proteins
pubmed
8672487
uniprot
proteins
pubmed
8783262
uniprot
proteins
pubmed
8942668
uniprot
proteins
pubmed
9272950
uniprot
proteins
pubmed
9622483
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P00813}; Peripheral membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell junction {ECO:0000250|UniProtKB:P00813}. Cytoplasmic vesicle lumen {ECO:0000269|PubMed:8783262}. Cytoplasm {ECO:0000250}. Lysosome {ECO:0000250|UniProtKB:P00813}. Note=Colocalized with DPP4 at the cell surface. {ECO:0000250|UniProtKB:P00813}.
uniprot
proteins