Glrx3
entrez
58815
canonical
uniprot
Q9JLZ1
canonical
ensembl
ENSRNOG00000016227
resolver
ensembl
ENSRNOG00055028491
resolver
ensembl
ENSRNOG00060026487
resolver
ensembl
ENSRNOG00065018504
resolver
ensp
ENSRNOP00000022406
resolver
ensp
ENSRNOP00000073509
resolver
enst
ENSRNOT00000083316
resolver
genesymbol
Glrx3
resolver
genesymbol_syn
Picot
resolver
genesymbol_syn
Txnl2
resolver
uniprot
A0A0G2K5P8
resolver
uniprot
Q5RK11
resolver
uniprot_entry
A0A0G2K5P8_RAT
resolver
uniprot_entry
GLRX3_RAT
resolver
uniprot_sec
Q5RK11
resolver
amino_acid_sequence
MAAGAAEAAEAAVAVVEVGSARQFEELLRLKTKSLLVVHFWAPWAPQCVQMNDVMAELAKEHPHVSFVKLEAEAVPEVSEKYEISSVPTFLFFKNSQKVDRLDGAHAPELTKKVQRHVSSGSFPPSTNEHVKEDLNLRLKKLTHAAPCMLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSFDIFSDEEVRQGLKTYSNWPTYPQLYVSGELIGGLDIIKELEASEELDTICPKAPKLEERLKVLTNKASVMLFMKGNKQEAKCGFSKQILEILNSTGVEYETFDILEDEEVRQGLKTFSNWPTYPQLYVRGDLVGGLDIVKELKDNGELLPILKGEN
uniprot
proteins
function
FUNCTION: Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (PubMed:16809552, PubMed:18258855). Required for hemoglobin maturation (By similarity). Does not possess any thioredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). {ECO:0000250|UniProtKB:O76003, ECO:0000250|UniProtKB:Q9CQM9, ECO:0000269|PubMed:16809552, ECO:0000269|PubMed:18258855}.
uniprot
proteins
mass_dalton
37849
uniprot
proteins
pubmed
10636891
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16809552
uniprot
proteins
pubmed
18258855
uniprot
proteins
pubmed
18479680
uniprot
proteins
sequence_length
337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O76003}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:O76003}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q9CQM9}. Note=Under the plasma membrane (By similarity). After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (By similarity). In the Z line, found associated with CSRP3 (By similarity). {ECO:0000250|UniProtKB:Q9CQM9}.
uniprot
proteins