SLC22A6
entrez
9356
canonical
uniprot
Q4U2R8
canonical
ensembl
ENSG00000197901
resolver
ensp
ENSP00000353597
resolver
ensp
ENSP00000367102
resolver
ensp
ENSP00000396401
resolver
ensp
ENSP00000404441
resolver
ensp
ENSP00000526597
resolver
genesymbol
SLC22A6
resolver
genesymbol_syn
OAT1
resolver
genesymbol_syn
PAHT
resolver
hgnc
HGNC:10970
resolver
uniprot
A8MY93
resolver
uniprot
B2D0R6
resolver
uniprot
O95187
resolver
uniprot
O95742
resolver
uniprot
Q7LDA0
resolver
uniprot
Q8N192
resolver
uniprot
Q9NQA6
resolver
uniprot
Q9NQC2
resolver
uniprot
Q9UBG6
resolver
uniprot
Q9UEQ8
resolver
uniprot_entry
S22A6_HUMAN
resolver
uniprot_sec
A8MY93
resolver
uniprot_sec
B2D0R6
resolver
uniprot_sec
O95187
resolver
uniprot_sec
O95742
resolver
uniprot_sec
Q7LDA0
resolver
uniprot_sec
Q8N192
resolver
uniprot_sec
Q9NQA6
resolver
uniprot_sec
Q9NQC2
resolver
uniprot_sec
Q9UBG6
resolver
uniprot_sec
Q9UEQ8
resolver
amino_acid_sequence
MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQTRQQQEHQKYMVPLQASAQEKNGL
uniprot
proteins
function
FUNCTION: Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate (PubMed:11669456, PubMed:11907186, PubMed:14675047, PubMed:22108572, PubMed:23832370, PubMed:28534121, PubMed:9950961). Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine (PubMed:9887087). Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (PubMed:28534121). Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion (PubMed:11907186). Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP (PubMed:26377792). Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain (PubMed:22108572, PubMed:23832370). May transport glutamate (PubMed:26377792). Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body (PubMed:11669456, PubMed:14675047). Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate (CMPF) and urate (PubMed:14675047, PubMed:26377792). Xenobiotics include the mycotoxin ochratoxin (OTA) (PubMed:11669456). May also contribute to the transport of organic compounds in testes across the blood-testis-barrier (PubMed:35307651). {ECO:0000269|PubMed:11669456, ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:14675047, ECO:0000269|PubMed:22108572, ECO:0000269|PubMed:23832370, ECO:0000269|PubMed:26377792, ECO:0000269|PubMed:28534121, ECO:0000269|PubMed:35307651, ECO:0000269|PubMed:9887087, ECO:0000269|PubMed:9950961}.
uniprot
proteins
mass_dalton
61816
uniprot
proteins
mutagenesis
MUTAGEN 30; /note="L->A: Complete loss of PAH transport activity."; /evidence="ECO:0000269|PubMed:15145940"; MUTAGEN 36; /note="T->A: Complete loss of PAH transport activity."; /evidence="ECO:0000269|PubMed:15145940"; MUTAGEN 39; /note="N->Q: Complete loss of PAH transport activity."; /evidence="ECO:0000269|PubMed:14749323"; MUTAGEN 230; /note="Y->A: Loss of membrane protein expression and little uptake of cidofovir."; /evidence="ECO:0000269|PubMed:17038320"; MUTAGEN 431; /note="K->A: Decrease in the level of membrane protein expression and 70 % loss of PAH uptake."; /evidence="ECO:0000269|PubMed:17038320"; MUTAGEN 438; /note="F->A: Decrease in the level of membrane protein expression, 70 % loss of PAH uptake, increased affinity for cidofovir, lower Vmax for PAH, and lower Km and Vmax for cidofovir."; /evidence="ECO:0000269|PubMed:17038320
uniprot
proteins
post_translational_modification
PTM: Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane. {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:14749323}.
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
10049739
uniprot
proteins
pubmed
10462545
uniprot
proteins
pubmed
10964714
uniprot
proteins
pubmed
11669456
uniprot
proteins
pubmed
11907186
uniprot
proteins
pubmed
12538807
uniprot
proteins
pubmed
14675047
uniprot
proteins
pubmed
14749323
uniprot
proteins
pubmed
15145940
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15644426
uniprot
proteins
pubmed
15914676
uniprot
proteins
pubmed
16164626
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17038320
uniprot
proteins
pubmed
17502342
uniprot
proteins
pubmed
22108572
uniprot
proteins
pubmed
23832370
uniprot
proteins
pubmed
26377792
uniprot
proteins
pubmed
28534121
uniprot
proteins
pubmed
35307651
uniprot
proteins
pubmed
9762842
uniprot
proteins
pubmed
9887087
uniprot
proteins
pubmed
9950961
uniprot
proteins
sequence_length
563
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:9887087}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the basolateral membrane of renal proximal tubular cells (PubMed:9887087). Localized to the basal membrane of Sertoli cells (PubMed:35307651). {ECO:0000269|PubMed:35307651, ECO:0000269|PubMed:9887087}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 165..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 191..213; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 249..269; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 338..358; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 369..389; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 396..416; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 426..446; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 456..475; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 485..505; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins