Clcnka
entrez
12733
canonical
uniprot
Q9WUB7
canonical
ensembl
ENSMUSG00000033770
resolver
ensp
ENSMUSP00000048520
resolver
ensp
ENSMUSP00000101416
resolver
enst
ENSMUST00000042617
resolver
enst
ENSMUST00000105790
resolver
genesymbol
Clcnka
resolver
genesymbol_syn
Clcnk1
resolver
uniprot
A2ADB3
resolver
uniprot
Q6UB69
resolver
uniprot
Q8JZU7
resolver
uniprot_entry
CLCKA_MOUSE
resolver
uniprot_sec
A2ADB3
resolver
uniprot_sec
Q6UB69
resolver
uniprot_sec
Q8JZU7
resolver
amino_acid_sequence
MEELVGLREGSSGKPVTLQELWGPCPRIRRGIRGGLEWLKERLFRAREDWYFLVALGVLMALISYAMNFAIGRVVRAHKWLYREVGDGHLLRYLSWTVYPVALLSFSSGFSQSITPFSGGSGLPELKTMLSGVVLENYLDIKNFGAKVVGLSCTLATGSTIFLGKVGPFVHLSVMISAYLGRVRAKAVGDTESKAKEVEMLSAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVWNYWRGFFAATCGAFMFRLLAVFNSEQETITSIYKTRFRVDVPFDLPEIFFFVALGFICGILSCVYLFCQRNFLRFIKTNRYTSKLLATSKPSYAALVALVLASVTYPPGVGRFMASRLSMAEHLHSLFDNNSWALMTRNASPPWPSEPDPQNLWFEWYHPRFTIFGTLAFFLIMKFWMLILATTIPMPAGYFMPIFIIGAAIGRLLGEALSVAFPEGIVAGGEVYPIMPGGYALAGAAAFSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANVISQNLQPSFYDGTIMAKKLPYLPWIRGRQIGSYPVTVEHFMNSNLTTLAKDMPLEEVVKVVTSTDVSQYPLVETRESQTLVGIVERTHLVQALQTQPASWAPGQERFLQDILAGGCPTQPVTLQLSPETSLYQAHRLFELLTLQALFVTSRGRAVGSVSWVELKKAISTLINPPAPK
uniprot
proteins
function
FUNCTION: Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide (PubMed:23791703). Forms a homodimeric channel where each subunit has its own ion conduction pathway. May conduct double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously (PubMed:23791703). Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain and functional switch to the ion conducting state. CLCNKA:BSND channels display mostly a linear current-voltage relationship with fast gating at negative potentials (PubMed:23791703). Mediates transepithelial chloride transport from the lumen to interstitial compartment along the thin ascending limb of Henle's loop, contributing to generation of hypertonic medullary interstitium as a countercurrent system to achieve urine concentration (PubMed:34499620, PubMed:9916798). Conducts chloride currents in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (By similarity). {ECO:0000250|UniProtKB:P51800, ECO:0000269|PubMed:23791703, ECO:0000269|PubMed:34499620, ECO:0000269|PubMed:9916798}.
uniprot
proteins
mass_dalton
75684
uniprot
proteins
mutagenesis
MUTAGEN 166; /note="V->E: Reduces the unit conductance from 40 pS to around 20 pS; displays outward rectification with half maximal activation voltage shifted to more positive potentials."; /evidence="ECO:0000269|PubMed:23791703"; MUTAGEN 166; /note="V->L: No significant effect on the unit conductance."; /evidence="ECO:0000269|PubMed:23791703"; MUTAGEN 166; /note="V->M: Moderately reduces the unit conductance."; /evidence="ECO:0000269|PubMed:23791703
uniprot
proteins
protein_family
CLCNKA subfamily
uniprot
proteins
protein_family
Chloride channel (TC 2.A.49) family
uniprot
proteins
pubmed
11014860
uniprot
proteins
pubmed
11734858
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23791703
uniprot
proteins
pubmed
34499620
uniprot
proteins
pubmed
9916798
uniprot
proteins
sequence_length
687
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000305|PubMed:11734858}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 282..302; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 325..345; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 396..416; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 417..437; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 458..478; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 486..506; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins