Amdhd1
entrez
71761
canonical
uniprot
Q9DBA8
canonical
ensembl
ENSMUSG00000015890
resolver
ensp
ENSMUSP00000016034
resolver
ensp
ENSMUSP00000191092
resolver
enst
ENSMUST00000016034
resolver
genesymbol
Amdhd1
resolver
uniprot
Q7TPP5
resolver
uniprot
Q811K3
resolver
uniprot
Q8R230
resolver
uniprot_entry
HUTI_MOUSE
resolver
uniprot_sec
Q7TPP5
resolver
uniprot_sec
Q811K3
resolver
uniprot_sec
Q8R230
resolver
amino_acid_sequence
MTSSHRLLLENAQQVVLVCARGERFLTGSALRSLAVLEGASVVVGTDGLIKAVGPAAVIQKQFSGETFEERIDCSGKCVLPGLVDAHTHPVWAGERVHEFAMKLAGATYMDIHQAGGGINFTVEHTRQASEEELFCSFQQRLQCMMRAGTTLVECKSGYGLNLETELKMLRVIERARRELHLSLSATYCGAHSVPKGKTAVEAADDIISHHLPRLKELSRNGDLHVDNIDVFCEKGVFDLDTTRRILEGGKKMGLQINFHGDELHPMKAAELGAELGAQAISHLEEVSDEGIAAMAAARCSAVLLPTTAYMLRLKQPRARKMLDEGVIVALGSDFNPNAYCFSMPMVMHLACVNMRMSMPEALAAATINAAYALGKSHTHGSLEVGKQGDAIIINASRWEHLIYQFGGHHELIDYVITKGKVIYKK
uniprot
proteins
ec_number
3.5.2.7
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to form N-formimidoyl-L-glutamate. This reaction represents the third step of the universal histidine degradation pathway. In addition to its metabolic role, functions as a tumor suppressor by promoting TGF-beta signaling. Mechanistically, inhibits ubiquitination and proteasomal degradation of SMAD4, thereby stabilizing the protein. Enhances SMAD2/3 phosphorylation and increases TGF-beta-dependent transcriptional responses. Consequently, promotes apoptosis and induces cell cycle arrest in tumor cells. {ECO:0000250|UniProtKB:P42084, ECO:0000250|UniProtKB:Q96NU7}.
uniprot
proteins
mass_dalton
46489
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. {ECO:0000250|UniProtKB:P42084}.
uniprot
proteins
protein_family
HutI family
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96NU7}.
uniprot
proteins