Nphs1
entrez
54631
canonical
uniprot
Q9QZS7
canonical
ensembl
ENSMUSG00000006649
resolver
ensp
ENSMUSP00000006825
resolver
ensp
ENSMUSP00000116500
resolver
genesymbol
Nphs1
resolver
genesymbol_syn
Nphn
resolver
uniprot
D2KXA7
resolver
uniprot
Q811S5
resolver
uniprot
Q925S5
resolver
uniprot
Q9ESC6
resolver
uniprot
Q9ET59
resolver
uniprot
Q9JIX1
resolver
uniprot_entry
NPHN_MOUSE
resolver
uniprot_sec
D2KXA7
resolver
uniprot_sec
Q811S5
resolver
uniprot_sec
Q925S5
resolver
uniprot_sec
Q9ESC6
resolver
uniprot_sec
Q9ET59
resolver
uniprot_sec
Q9JIX1
resolver
amino_acid_sequence
MGAKEATVRGPGASPVHRTCHLIPLLLAGMLTTGLAQSPVPTSAPRGFWALSENLTVVEGSTVKLWCGVRAPGSVVQWAKDGLLLGPNPKIPGFPRYSLEGDSAKGEFHLLIEACDLSDDAEYECQVGRSELGPELVSPSVILSILVSPKVLQLTPEAGSTVTWVAGQEYVVTCVSGDAKPAPDIIFIQGGRTVEDVSSSVNEGSEEKLFFTEAEARVTPQSSDNGQLLVCEGSNPALATPIKASFTMNILFPPGPPVIDWPGLNEGHVRAGENLELPCIARGGNPPATLQWLKNGKPVSIAWGTEHAQAVAHSVLVMTVRPEDHGARLSCQSYNSVSAETQERSITLQVTFPPSAVTILGSTSQSENKNVTLCCLTKSSRPRVLLRWWLGGRQLLPTDETVMDGLHGGHISMSNLTLLVKREDNGLSLTCEAFSDAFSKETFKKSLTLNVKYPAQKLWIEGPPEGQSIRTGTRVRLVCLAIGGNPEPSLTWLKDSRPVNDPRQSQEPRRVQLGSVEKSGSTFSRELVLIIGPPDNLAKFSCKAGQLSASTQLVVQFPPTNLTILANSSALRPGDALNLTCVSISSNPPVNLSLDKEGERLDDVAAKPQSAPFKGSAASRSVFLRVSSRDHGHRVTCRAHSEALRETVSSFYRLNVLYPPEFLGEQVRAVTVVEQGQALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSGGALQLWNVTRADDGFYQLHCQNSEGTAEALLKLDVHYAPTIRALKDPTEVNVGGSVDIVCTVDANPILPEMFSWERLGEDEEELNLDDMEKMSKGSTGRLRIRQAKLSQAGAYQCIVDNGVAPAARGLVRLVVRFAPQVDHPTPLTKVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHKYHQGVVHSSLLTIANVSAAQDYALFKCTATNALGSDHTNIQLVSISRPDPPLGLKVVSVSPHSVGLEWKPGFDGGLPQRFQIRYEALESPGFLYMDVLPAQATTFTLTGLKPSTRYRIWLLASNALGDSGLTDKGIQVSITTPGLDQAPEDTDQPLPTEQPPGPPRLPLLPVLFAVGGLLLLSNASCVGGLLWRRRLRRLAEEISEKTEAGSEEDRIRNEYEESQWTGDRDTRSSTVSTAEVDPHYYSMRDFSPQLPPTLEEVSYRQAFTGIEDEDMAFPGHLYDEVERVYGPPGVWGPLYDEVQMDPYDLRWPEVKYEDPRGIYDQVAADMDAGEPGSLPFELRGHLV
uniprot
proteins
function
FUNCTION: Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion. {ECO:0000269|PubMed:11136707, ECO:0000269|PubMed:12039968, ECO:0000269|PubMed:19470472}.
uniprot
proteins
mass_dalton
136336
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Tyr-1208 by FYN, leading to the recruitment and activation of phospholipase C-gamma-1/PLCG1 (By similarity). Tyrosine phosphorylation is reduced by high glucose levels (By similarity). Dephosphorylated by tensin TNS2 which leads to reduced binding of NPHN1 to PIK3R1 (By similarity). {ECO:0000250|UniProtKB:O60500, ECO:0000250|UniProtKB:Q9R044}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
10504499
uniprot
proteins
pubmed
10820162
uniprot
proteins
pubmed
11136707
uniprot
proteins
pubmed
11733379
uniprot
proteins
pubmed
11733557
uniprot
proteins
pubmed
12039968
uniprot
proteins
pubmed
12424224
uniprot
proteins
pubmed
12538735
uniprot
proteins
pubmed
12660326
uniprot
proteins
pubmed
15843475
uniprot
proteins
pubmed
17537921
uniprot
proteins
pubmed
18752272
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19470472
uniprot
proteins
pubmed
19887377
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1256
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Located at podocyte slit diaphragm between podocyte foot processes. {ECO:0000269|PubMed:10504499}.
uniprot
proteins
transmembrane_region
TRANSMEM 1079..1099; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins