Glra2
entrez
237213
canonical
uniprot
Q7TNC8
canonical
ensembl
ENSMUSG00000018589
resolver
ensp
ENSMUSP00000060827
resolver
ensp
ENSMUSP00000245344
resolver
ensp
ENSMUSP00000245345
resolver
enst
ENSMUST00000058787
resolver
genesymbol
Glra2
resolver
uniprot
Q3UTL8
resolver
uniprot_entry
GLRA2_MOUSE
resolver
uniprot_entry
Q3UTL8_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Inhibited by strychnine. Inhibited by picrotoxin. {ECO:0000250|UniProtKB:P23416}.
uniprot
proteins
amino_acid_sequence
MYRQLVNILTALFAFFLGTNHFREAFCKDHDSRSGKHPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQMKDGTAVKATPANPLPQPPKDADAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
uniprot
proteins
function
FUNCTION: Subunit of heteromeric glycine-gated chloride channels (By similarity). Plays a role in synaptic plasticity (PubMed:26370147). Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability. Plays a role in cellular responses to ethanol. {ECO:0000250|UniProtKB:P23416, ECO:0000269|PubMed:26370147}.
uniprot
proteins
mass_dalton
52062
uniprot
proteins
protein_family
GLRA2 sub-subfamily
uniprot
proteins
protein_family
Glycine receptor (TC 1.A.9.3) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
15329889
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16847326
uniprot
proteins
pubmed
21924294
uniprot
proteins
pubmed
26370147
uniprot
proteins
sequence_length
452
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:15329889}; Multi-pass membrane protein {ECO:0000305}. Synapse {ECO:0000269|PubMed:15329889}. Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Cell projection {ECO:0000269|PubMed:15329889}.
uniprot
proteins
transmembrane_region
TRANSMEM 257..278; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P23415"; TRANSMEM 284..304; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P23415"; TRANSMEM 316..336; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P23415"; TRANSMEM 421..441; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P23415
uniprot
proteins