PITPNA
entrez
5306
canonical
uniprot
Q00169
canonical
ensembl
ENSG00000174238
resolver
ensp
ENSP00000316809
resolver
enst
ENST00000313486
resolver
genesymbol
HEL-S-36
resolver
genesymbol
PITPNA
resolver
genesymbol_syn
PITPN
resolver
hgnc
HGNC:9001
resolver
uniprot
B4E1U1
resolver
uniprot
V9HWC5
resolver
uniprot_entry
B4E1U1_HUMAN
resolver
uniprot_entry
PIPNA_HUMAN
resolver
uniprot_entry
V9HWC5_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Phosphatidylinositol transfer activity is inhibited by N-ethylmaleimide. {ECO:0000269|PubMed:18636990}.
uniprot
proteins
amino_acid_sequence
MVLLKEYRVILPVSVDEYQVGQLYSVAEASKNETGGGEGVEVLVNEPYEKDGEKGQYTHKIYHLQSKVPTFVRMLAPEGALNIHEKAWNAYPYCRTVITNEYMKEDFLIKIETWHKPDLGTQENVHKLEPEAWKHVEAVYIDIADRSQVLSKDYKAEEDPAKFKSIKTGRGPLGPNWKQELVNQKDCPYMCAYKLVTVKFKWWGLQNKVENFIHKQERRLFTNFHRQLFCWLDKWVDLTMDDIRRMEEETKRQLDEMRQKDPVKGMTADD
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:10531358, PubMed:14962392, PubMed:15522822, PubMed:18636990, PubMed:22822086). Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (PubMed:15522822, PubMed:22822086). Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (PubMed:22822086). {ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:14962392, ECO:0000269|PubMed:15522822, ECO:0000269|PubMed:18636990, ECO:0000269|PubMed:22822086}.
uniprot
proteins
mass_dalton
31806
uniprot
proteins
mutagenesis
MUTAGEN 58; /note="T->A: Reduced phosphatidylinositol and phosphatidylcholine transfer activity."; /evidence="ECO:0000269|PubMed:14962392"; MUTAGEN 58; /note="T->E: Complete loss of phosphatidylinositol transfer activity but no effect on phosphatidylcholine transfer activity."; /evidence="ECO:0000269|PubMed:14962392"; MUTAGEN 58; /note="T->S: Reduced phosphatidylinositol transfer activity but no effect on phosphatidylcholine transfer activity."; /evidence="ECO:0000269|PubMed:14962392"; MUTAGEN 60; /note="K->A: Complete loss of phosphatidylinositol transfer activity but no effect on phosphatidylcholine transfer activity."; /evidence="ECO:0000269|PubMed:14962392"; MUTAGEN 85; /note="E->A: Reduced phosphatidylinositol transfer activity but no effect on phosphatidylcholine transfer activity."; /evidence="ECO:0000269|PubMed:14962392"; MUTAGEN 85; /note="E->Q: Reduced phosphatidylinositol and phosphatidylcholine transfer activity."; /evidence="ECO:0000269|PubMed:14962392"; MUTAGEN 89; /note="N->F,L: Significant loss of phosphatidylinositol transfer activity but no effect on phosphatidylcholine transfer activity."; /evidence="ECO:0000269|PubMed:14962392"; MUTAGEN 94; /note="C->A,T: No effect on phosphatidylinositol transfer activity. Resistant to inhibition by N-ethylmaleimide."; /evidence="ECO:0000269|PubMed:18636990"; MUTAGEN 102; /note="Y->A: Reduced phosphatidylinositol and phosphatidylcholine transfer activity."; /evidence="ECO:0000269|PubMed:14962392"; MUTAGEN 187; /note="C->A: No effect on phosphatidylinositol transfer activity."; /evidence="ECO:0000269|PubMed:18636990"; MUTAGEN 202..203; /note="WW->AA: Significant loss of phosphatidylinositol and phosphatidylcholine transfer activity."; /evidence="ECO:0000269|PubMed:14962392, ECO:0000269|PubMed:18636990
uniprot
proteins
protein_family
PI transfer class I subfamily
uniprot
proteins
protein_family
PtdIns transfer protein family
uniprot
proteins
pubmed
10531358
uniprot
proteins
pubmed
14962392
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15522822
uniprot
proteins
pubmed
18636990
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22822086
uniprot
proteins
pubmed
8194769
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P16446}. Nucleus {ECO:0000250|UniProtKB:P53810}. Note=Primarily localized in the cytosol in its closed state, is enriched on membranes in its open state where it facilitates lipid transfer. {ECO:0000250|UniProtKB:P16446}.
uniprot
proteins