Cdh2
entrez
12558
canonical
uniprot
P15116
canonical
ensembl
ENSMUSG00000024304
resolver
ensp
ENSMUSP00000025166
resolver
enst
ENSMUST00000025166
resolver
genesymbol
Cdh2
resolver
uniprot
Q3UIC2
resolver
uniprot
Q64260
resolver
uniprot
Q6GU11
resolver
uniprot
Q8BSI9
resolver
uniprot_entry
CADH2_MOUSE
resolver
uniprot_entry
Q3UIC2_MOUSE
resolver
uniprot_entry
Q8BSI9_MOUSE
resolver
uniprot_sec
Q64260
resolver
uniprot_sec
Q6GU11
resolver
amino_acid_sequence
MCRIAGAPRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLPKDVHEGQPLLNVKFSNCNRKRKVQYESSEPADFKVDEDGTVYAVRSFPLTAEQAKFLIYAQDKETQEKWQVAVNLSREPTLTEEPMKEPHEIEEIVFPRQLAKHSGALQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGSVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRILSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDVIVANLTVTDKDQPHTPAWNAAYRISGGDPTGRFAILTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTLTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPEPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTINRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRLDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYGGGDD
uniprot
proteins
function
FUNCTION: Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell (PubMed:11433297, PubMed:17988630, PubMed:25253890, PubMed:2762814, PubMed:9655503). Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence (PubMed:24952463). Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (PubMed:26750727). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (PubMed:25496840). {ECO:0000250|UniProtKB:P10288, ECO:0000269|PubMed:11433297, ECO:0000269|PubMed:17988630, ECO:0000269|PubMed:24952463, ECO:0000269|PubMed:25253890, ECO:0000269|PubMed:25496840, ECO:0000269|PubMed:26750727, ECO:0000269|PubMed:2762814, ECO:0000269|PubMed:9655503}.
uniprot
proteins
mass_dalton
99796
uniprot
proteins
mutagenesis
MUTAGEN 150; /note="H->Y: CRISPR/Cas9-mutated knockin mice manifest motor-associated features of hyperactivity such as greater traveling distance, increased velocity and prolonged mobility time compared with control mice. Synaptic release is attenuated in neuron from mutant mice and synaptic vesicle clusters size is reduced in presynaptic terminals."; /evidence="ECO:0000269|PubMed:34702855"; MUTAGEN 161; /note="W->A,Y: Loss of calcium-dependent cell-cell adhesion."; /evidence="ECO:0000269|PubMed:9655503"; MUTAGEN 161; /note="W->A: Loss of dimerization; when associated with E-173."; /evidence="ECO:0000269|PubMed:25253890"; MUTAGEN 162; /note="V->A: Decreased calcium-dependent cell-cell adhesion."; /evidence="ECO:0000269|PubMed:9655503"; MUTAGEN 173; /note="R->E: Loss of dimerization; when associated with A-161."; /evidence="ECO:0000269|PubMed:25253890"; MUTAGEN 237; /note="A->M: Loss of calcium-dependent cell-cell adhesion."; /evidence="ECO:0000269|PubMed:9655503"; MUTAGEN 239; /note="A->M: Loss of calcium-dependent cell-cell adhesion."; /evidence="ECO:0000269|PubMed:9655503"; MUTAGEN 262; /note="D->A: Abolishes dimerization."; /evidence="ECO:0000269|PubMed:21366346"; MUTAGEN 293; /note="D->A: Severely impaired the binding of calcium to all three sites."; /evidence="ECO:0000269|PubMed:21366346
uniprot
proteins
post_translational_modification
PTM: Cleaved by MMP24 (PubMed:19805319, PubMed:24952463). Ectodomain cleavage leads to the generation of a soluble 90 kDa N-terminal soluble fragment and a 45 kDa membrane-bound C-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa (PubMed:24952463). Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (PubMed:24952463). {ECO:0000269|PubMed:19805319, ECO:0000269|PubMed:24952463}.; PTM: May be phosphorylated by OBSCN. {ECO:0000269|PubMed:23392350}.; PTM: O-glycosylated on Ser and Thr residues. {ECO:0000269|PubMed:21300292}.
uniprot
proteins
pubmed
11433297
uniprot
proteins
pubmed
1528849
uniprot
proteins
pubmed
15479741
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17988630
uniprot
proteins
pubmed
19805319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21300292
uniprot
proteins
pubmed
21366346
uniprot
proteins
pubmed
23001562
uniprot
proteins
pubmed
23392350
uniprot
proteins
pubmed
24952463
uniprot
proteins
pubmed
25232112
uniprot
proteins
pubmed
25253890
uniprot
proteins
pubmed
25496840
uniprot
proteins
pubmed
26403541
uniprot
proteins
pubmed
26750727
uniprot
proteins
pubmed
2762814
uniprot
proteins
pubmed
31650526
uniprot
proteins
pubmed
34702855
uniprot
proteins
pubmed
7885471
uniprot
proteins
pubmed
8879495
uniprot
proteins
pubmed
9655503
uniprot
proteins
sequence_length
906
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17988630, ECO:0000269|PubMed:26403541, ECO:0000269|PubMed:9655503}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000269|PubMed:23392350}. Cell junction {ECO:0000269|PubMed:26750727}. Cell junction, adherens junction {ECO:0000269|PubMed:15479741}. Cell junction, desmosome {ECO:0000269|PubMed:15479741}. Cell surface {ECO:0000269|PubMed:25232112, ECO:0000269|PubMed:9655503}. Cell projection, axon {ECO:0000269|PubMed:25496840}. Note=Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes (PubMed:26403541). Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes (PubMed:23392350). {ECO:0000269|PubMed:23392350, ECO:0000269|PubMed:26403541}.
uniprot
proteins
transmembrane_region
TRANSMEM 725..745; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins