Q08463
uniprot
Q08463
canonical
amino_acid_sequence
MAEEAVPSESRAAGRPSLELCAVALPGRREEVGHQDTAGHRRPRAHSRCWARGLLLLLWLLEAPLLLGVRAQPAGQVSGPGQQRPPPPQPQQGGQQYNGERGISIPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERAQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGYRGGYPGGAGPVERGKFSCPRALRVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6 or WNT7A. Contradictory results have been reported for activation by WNT7B. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). {ECO:0000250|UniProtKB:O70421, ECO:0000250|UniProtKB:Q9UP38, ECO:0000305}.
uniprot
proteins
mass_dalton
71027
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
10395542
uniprot
proteins
pubmed
1334084
uniprot
proteins
sequence_length
641
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9UP38}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 317..337; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 349..369; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 397..417; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 440..460; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 484..504; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 531..551; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 596..616; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins