Sbno2
entrez
216161
canonical
uniprot
Q7TNB8
canonical
ensembl
ENSMUSG00000035673
resolver
ensp
ENSMUSP00000041635
resolver
ensp
ENSMUSP00000151590
resolver
ensp
ENSMUSP00000151854
resolver
ensp
ENSMUSP00000315580
resolver
ensp
ENSMUSP00000315586
resolver
ensp
ENSMUSP00000339851
resolver
genesymbol
Sbno2
resolver
genesymbol_syn
Sno
resolver
genesymbol_syn
Stno
resolver
uniprot
Q3UE14
resolver
uniprot
Q6P3A3
resolver
uniprot
Q70X02
resolver
uniprot_entry
SBNO2_MOUSE
resolver
uniprot_sec
Q3UE14
resolver
uniprot_sec
Q6P3A3
resolver
uniprot_sec
Q70X02
resolver
amino_acid_sequence
MLAVEPTMDGDFPPHELPPPGGGIQLQNRLLHCPWWGSFSPSLYPTFSSENQQFVGSTPFLGGQSCPETSYPTTATVPSFFSKSSDFPQDPSCLEDLSNASVFSSSVDSLSDIPDTPDFLQADSLNEVPTIWDVSTTSTTHDKLFIPSGPFSAPEDPVTSLSSTPLLISYQSHSQPEEEEGEEEEETEELGHAETYADYVPSKSKIGKQHPDRVVETSTLSSVPPPDITYTLALPTSDNSTLSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAGIIVENYLRGRKKALWFSASNDLKYDAERDLRDIEAPGIAVHALSKIKYGDNTTSEGVLFATYSALIGESQAGGQHRTRLRQILQWCGEGFDGVIVFDECHKAKNASSTKMGKAVLDLQSKLPQARVVYASATGASEPRNMIYMSRLGIWGEGTPFRTFEEFLHAIEKRGVGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLSPAFQQVYNRAARLWAEALSVFQQAADWIGLESRKSLWGQFWSAHQRFFKYLCIAAKVHRLVELAQQELSRDKCVVIGLQSTGEARTREVLDENEGRLDCFVSAAEGVFLSLIQKHFPSTRRRRDRGGGKRKRRPRGRGPKASRLSLEAAGVIRISDGSSTESDAGLDSDFNSSPESLVDDDVVIVDAPTHPTDDRGSLYPLQRDLQGPGVVERVERLKQGLLAKVRALGRELPVNTLDQLIHQLGGPECVAEMTGRKGRVVSRPDGTVVFESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENKYGARALSRVLATIMGQTDNRVPLPQGYPGGDTAFFRDMKQGLLSVGIGSRESRSGCLDVEKDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEIDKKEGRYDMGILDLAPGINEIHEESQQVFLAPGHPQDGQVVFYKQISVDRGMKWEEALTRSLELKGPYDGFYLSYKVRGSKMSCLLAEQNRGEYFTVYKPNIGRQSQLETLDSLCRKFHRVTVEEAREPWESSYALSLEHCSHTTWNQRCRLTQEGKCCAQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKDKKKQVGIKIPEGCVHRVLQELQLMDAEVKRRSTHGLAARPPTPRAITLPCGPGEVLDLTYSPPAEAFPTPPRFAFPSLPPPDPSSLMLGARDPATNPVELAHQSCDINFREVLEDMLRSLRAGPTETPAPLVGVGGGGTERQSVIHFSPPFPNS
uniprot
proteins
function
FUNCTION: Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions (PubMed:18025162, PubMed:23980096). Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast (PubMed:23980096). Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway (PubMed:23980096). May also be required in the regulation of osteoblast differentiation (PubMed:23980096). Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the pro-inflammatory cascade (By similarity). {ECO:0000250|UniProtKB:Q9Y2G9, ECO:0000269|PubMed:23980096}.
uniprot
proteins
mass_dalton
149294
uniprot
proteins
protein_family
SBNO family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18025162
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23980096
uniprot
proteins
pubmed
25903009
uniprot
proteins
sequence_length
1349
uniprot
proteins