MAP3K11
entrez
4296
canonical
uniprot
Q16584
canonical
ensembl
ENSG00000173327
resolver
ensp
ENSP00000309597
resolver
ensp
ENSP00000646492
resolver
genesymbol
MAP3K11
resolver
genesymbol_syn
MLK3
resolver
genesymbol_syn
PTK1
resolver
genesymbol_syn
SPRK
resolver
hgnc
HGNC:6850
resolver
uniprot
B4DS76
resolver
uniprot
Q53H00
resolver
uniprot
Q59F06
resolver
uniprot
Q6P2G4
resolver
uniprot_entry
M3K11_HUMAN
resolver
uniprot_sec
B4DS76
resolver
uniprot_sec
Q53H00
resolver
uniprot_sec
Q59F06
resolver
uniprot_sec
Q6P2G4
resolver
activity_regulation
ACTIVITY REGULATION: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation. {ECO:0000269|PubMed:11053428, ECO:0000269|PubMed:9829970}.
uniprot
proteins
amino_acid_sequence
MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}.
uniprot
proteins
mass_dalton
92688
uniprot
proteins
mutagenesis
MUTAGEN 144; /note="K->A: Greatly reduced autophosphorylation activity."; /evidence="ECO:0000269|PubMed:11053428, ECO:0000269|PubMed:8195146"; MUTAGEN 144; /note="K->R: Loss of kinase activity. Prevents activation of SAPK and MAPK14."; /evidence="ECO:0000269|PubMed:11053428, ECO:0000269|PubMed:8195146"; MUTAGEN 164; /note="E->A: Greatly reduced autophosphorylation activity."; /evidence="ECO:0000269|PubMed:8195146"; MUTAGEN 277; /note="T->A: Severely reduced autophosphorylation activity. Prevents phosphorylation of SAPK and MAPK14."; /evidence="ECO:0000269|PubMed:11053428"; MUTAGEN 277; /note="T->E: No effect on SAPK activation."; /evidence="ECO:0000269|PubMed:11053428"; MUTAGEN 278; /note="T->A: No effect on autophosphorylation activity or activation of SAPK and MAPK14."; /evidence="ECO:0000269|PubMed:11053428"; MUTAGEN 281; /note="S->A: Reduced autophosphorylation activity. Reduced activation of SAPK and MAPK14."; /evidence="ECO:0000269|PubMed:11053428"; MUTAGEN 281; /note="S->E: No effect on SAPK activation."; /evidence="ECO:0000269|PubMed:11053428
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-277 is likely to be the main autophosphorylation site. Phosphorylation of Ser-555 and Ser-556 is induced by CDC42. {ECO:0000269|PubMed:11053428, ECO:0000269|PubMed:11969422, ECO:0000269|PubMed:8195146}.
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
11053428
uniprot
proteins
pubmed
11969422
uniprot
proteins
pubmed
12529434
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15258589
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8183572
uniprot
proteins
pubmed
8195146
uniprot
proteins
pubmed
9003778
uniprot
proteins
pubmed
9829970
uniprot
proteins
sequence_length
847
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12529434}. Note=Location is cell cycle dependent.
uniprot
proteins