ABCC4
entrez
10257
canonical
uniprot
O15439
canonical
ensembl
ENSG00000125257
resolver
ensp
ENSP00000442024
resolver
ensp
ENSP00000487081
resolver
ensp
ENSP00000494609
resolver
ensp
ENSP00000494751
resolver
genesymbol
ABCC4
resolver
genesymbol_syn
MOATB
resolver
genesymbol_syn
MRP4
resolver
hgnc
HGNC:55
resolver
uniprot
A8K2Q2
resolver
uniprot
A9Z1Z7
resolver
uniprot
B7Z3Q7
resolver
uniprot
Q8IVZ4
resolver
uniprot
Q8IZN6
resolver
uniprot
Q8NEW8
resolver
uniprot
Q9Y6J2
resolver
uniprot_entry
A8K2Q2_HUMAN
resolver
uniprot_entry
MRP4_HUMAN
resolver
uniprot_sec
A9Z1Z7
resolver
uniprot_sec
B7Z3Q7
resolver
uniprot_sec
Q8IVZ4
resolver
uniprot_sec
Q8IZN6
resolver
uniprot_sec
Q8NEW8
resolver
uniprot_sec
Q9Y6J2
resolver
activity_regulation
ACTIVITY REGULATION: GSH stimulates the transport of MRP4 (PubMed:17959747). Urate inhibits methotrexate transport but stimulates cGMP transport (PubMed:15454390). Nonsteroidal anti-inflammatory drugs (NSAIDs) strongly suppress the transport of MRP4 substrates (PubMed:12835412). {ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:17959747}.
uniprot
proteins
amino_acid_sequence
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQPSTLTIFETAL
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
ec_number
7.6.2.3
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells (PubMed:11856762, PubMed:12523936, PubMed:15364914, PubMed:38886124, PubMed:40138312). Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430, PubMed:38886124, PubMed:40138312). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). May contribute to hepatic, intestinal and renal excretion of steroid conjugates. Selectively transports steroid glucuronates and sulfates. Mediates the efflux of estrogens glucuronated at C-16 and C-17 positions, but has no transporter activity toward estrogens glucuronated at C-3. Has high affinity for dehydroepiandrosterone-3-sulfate and can also transport testosterone-17-sulfate, but has no transporter activity toward androsterone and etiocholanolone sulfate conjugates. Does not transport estrone 3-sulfate (PubMed:29175180, PubMed:39993711). Displays low affinity and high transport velocity for folates (PubMed:12036927). Transports a wide range of drugs and their metabolites. including anticancer, antiviral and antibiotic molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). May confer resistance to anticancer agents. Can mediate the efflux of methotrexate but is inactive toward polyglutaminated methotrexate, which is the predominant intracellular form (PubMed:11106685, PubMed:12036927). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12036927, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430, ECO:0000269|PubMed:29175180, ECO:0000269|PubMed:38886124, ECO:0000269|PubMed:39993711, ECO:0000269|PubMed:40138312}.
uniprot
proteins
mass_dalton
149527
uniprot
proteins
mutagenesis
MUTAGEN 746; /note="N->Q: Does not affect plasma membrane localization; 1.5 fold increase in PEG2 transport; does not affect estradiol 17-beta-D-glucuronide transport."; /evidence="ECO:0000269|PubMed:26721430"; MUTAGEN 754; /note="N->Q: Does not affect plasma membrane localization; PEG2 transport is decreased by 50%; does not affect estradiol 17-beta-D-glucuronide transport."; /evidence="ECO:0000269|PubMed:26721430
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; leading to substrate-selective effects on its transport activity. {ECO:0000269|PubMed:26721430}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCC family
uniprot
proteins
protein_family
Conjugate transporter (TC 3.A.1.208) subfamily
uniprot
proteins
pubmed
11106685
uniprot
proteins
pubmed
11856762
uniprot
proteins
pubmed
12036927
uniprot
proteins
pubmed
12105214
uniprot
proteins
pubmed
12523936
uniprot
proteins
pubmed
12835412
uniprot
proteins
pubmed
12883481
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15364914
uniprot
proteins
pubmed
15454390
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16282361
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17344354
uniprot
proteins
pubmed
17959747
uniprot
proteins
pubmed
18300232
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20547088
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22411990
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26721430
uniprot
proteins
pubmed
29175180
uniprot
proteins
pubmed
38886124
uniprot
proteins
pubmed
39993711
uniprot
proteins
pubmed
40138312
uniprot
proteins
pubmed
9270026
uniprot
proteins
pubmed
9661885
uniprot
proteins
sequence_length
1325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:26721430}; Multi-pass membrane protein {ECO:0000269|PubMed:38886124, ECO:0000269|PubMed:40138312}. Apical cell membrane {ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:26721430}; Multi-pass membrane protein {ECO:0000269|PubMed:38886124, ECO:0000269|PubMed:40138312}. Note=Its localization to the basolateral or apical membranes is tissue-dependent. {ECO:0000305|PubMed:26721430}.
uniprot
proteins
transmembrane_region
TRANSMEM 89..131; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:38886124, ECO:0000269|PubMed:40138312, ECO:0007744|PDB:8XOK, ECO:0007744|PDB:8XOL, ECO:0007744|PDB:8XOM, ECO:0007744|PDB:8ZBS, ECO:0007744|PDB:8ZBT, ECO:0007744|PDB:8ZBU"; TRANSMEM 137..176; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:38886124, ECO:0000269|PubMed:40138312, ECO:0007744|PDB:8XOK, ECO:0007744|PDB:8XOL, ECO:0007744|PDB:8XOM, ECO:0007744|PDB:8ZBS, ECO:0007744|PDB:8ZBT, ECO:0007744|PDB:8ZBU"; TRANSMEM 211..244; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:38886124, ECO:0000269|PubMed:40138312, ECO:0007744|PDB:8XOK, ECO:0007744|PDB:8XOL, ECO:0007744|PDB:8XOM, ECO:0007744|PDB:8ZBS, ECO:0007744|PDB:8ZBT, ECO:0007744|PDB:8ZBU"; TRANSMEM 247..274; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:38886124, ECO:0000269|PubMed:40138312, ECO:0007744|PDB:8XOK, ECO:0007744|PDB:8XOL, ECO:0007744|PDB:8XOM, ECO:0007744|PDB:8ZBS, ECO:0007744|PDB:8ZBT, ECO:0007744|PDB:8ZBU"; TRANSMEM 319..352; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:38886124, ECO:0000269|PubMed:40138312, ECO:0007744|PDB:8XOK, ECO:0007744|PDB:8XOL, ECO:0007744|PDB:8XOM, ECO:0007744|PDB:8ZBS, ECO:0007744|PDB:8ZBT, ECO:0007744|PDB:8ZBU"; TRANSMEM 357..390; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:38886124, ECO:0000269|PubMed:40138312, ECO:0007744|PDB:8XOK, ECO:0007744|PDB:8XOL, ECO:0007744|PDB:8XOM, ECO:0007744|PDB:8ZBS, ECO:0007744|PDB:8ZBT, ECO:0007744|PDB:8ZBU"; TRANSMEM 720..755; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:38886124, ECO:0000269|PubMed:40138312, ECO:0007744|PDB:8XOK, ECO:0007744|PDB:8XOL, ECO:0007744|PDB:8XOM, ECO:0007744|PDB:8ZBS, ECO:0007744|PDB:8ZBT, ECO:0007744|PDB:8ZBU"; TRANSMEM 769..803; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:38886124, ECO:0000269|PubMed:40138312, ECO:0007744|PDB:8XOK, ECO:0007744|PDB:8XOL, ECO:0007744|PDB:8XOM, ECO:0007744|PDB:8ZBS, ECO:0007744|PDB:8ZBT, ECO:0007744|PDB:8ZBU"; TRANSMEM 840..871; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:38886124, ECO:0000269|PubMed:40138312, ECO:0007744|PDB:8XOK, ECO:0007744|PDB:8XOL, ECO:0007744|PDB:8XOM, ECO:0007744|PDB:8ZBS, ECO:0007744|PDB:8ZBT, ECO:0007744|PDB:8ZBU"; TRANSMEM 874..892; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:38886124, ECO:0000269|PubMed:40138312, ECO:0007744|PDB:8XOK, ECO:0007744|PDB:8XOL, ECO:0007744|PDB:8XOM, ECO:0007744|PDB:8ZBS, ECO:0007744|PDB:8ZBT, ECO:0007744|PDB:8ZBU"; TRANSMEM 950..984; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:38886124, ECO:0000269|PubMed:40138312, ECO:0007744|PDB:8XOK, ECO:0007744|PDB:8XOL, ECO:0007744|PDB:8XOM, ECO:0007744|PDB:8ZBS, ECO:0007744|PDB:8ZBT, ECO:0007744|PDB:8ZBU"; TRANSMEM 985..1014; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:38886124, ECO:0000269|PubMed:40138312, ECO:0007744|PDB:8XOK, ECO:0007744|PDB:8XOL, ECO:0007744|PDB:8XOM, ECO:0007744|PDB:8ZBS, ECO:0007744|PDB:8ZBT, ECO:0007744|PDB:8ZBU
uniprot
proteins