GPR39
entrez
2863
canonical
uniprot
O43194
canonical
ensembl
ENSG00000183840
resolver
ensp
ENSP00000327417
resolver
enst
ENST00000329321
resolver
genesymbol
GPR39
resolver
hgnc
HGNC:4496
resolver
uniprot
B2RC12
resolver
uniprot
B6V9G4
resolver
uniprot
Q08AS2
resolver
uniprot
Q53R01
resolver
uniprot_entry
GPR39_HUMAN
resolver
uniprot_sec
B2RC12
resolver
uniprot_sec
B6V9G4
resolver
uniprot_sec
Q08AS2
resolver
uniprot_sec
Q53R01
resolver
amino_acid_sequence
MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAENGFQEHEV
uniprot
proteins
function
FUNCTION: Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed:18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (PubMed:20522546). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (By similarity). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (By similarity). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner (PubMed:18180304). Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity: HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (PubMed:26365466). {ECO:0000250|UniProtKB:Q5U431, ECO:0000269|PubMed:18180304, ECO:0000269|PubMed:20522546, ECO:0000269|PubMed:26365466}.
uniprot
proteins
mass_dalton
51329
uniprot
proteins
mutagenesis
MUTAGEN 17; /note="H->A: Decreases activation by Zn(2+). Abolishes activation by Zn(2+); when associated with A-19."; /evidence="ECO:0000269|PubMed:18588883"; MUTAGEN 19; /note="H->A: Decreases activation by Zn(2+). Abolishes activation by Zn(2+); when associated with A-17."; /evidence="ECO:0000269|PubMed:18588883"; MUTAGEN 312; /note="H->A: Not affect constitutive or Zn(2+)-induced activation."; /evidence="ECO:0000269|PubMed:18588883"; MUTAGEN 313; /note="D->A: Induces very high constitutive activity and eliminates Zn(2+)-induced activation."; /evidence="ECO:0000269|PubMed:18588883
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18180304
uniprot
proteins
pubmed
18588883
uniprot
proteins
pubmed
18693759
uniprot
proteins
pubmed
20522546
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26365466
uniprot
proteins
pubmed
9441746
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26365466}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 35..55; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 70..89; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 110..131; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 152..172; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 218..242; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 284..305; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P20789"; TRANSMEM 324..344; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P20789
uniprot
proteins