STAM2
entrez
10254
canonical
uniprot
O75886
canonical
ensembl
ENSG00000115145
resolver
ensp
ENSP00000263904
resolver
genesymbol
STAM2
resolver
genesymbol_syn
HBP
resolver
hgnc
HGNC:11358
resolver
uniprot
A8K8A0
resolver
uniprot
D3DPA1
resolver
uniprot
Q7LDQ0
resolver
uniprot
Q9UF58
resolver
uniprot_entry
STAM2_HUMAN
resolver
uniprot_sec
A8K8A0
resolver
uniprot_sec
D3DPA1
resolver
uniprot_sec
Q7LDQ0
resolver
uniprot_sec
Q9UF58
resolver
amino_acid_sequence
MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDKMDRALQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSELSELNVKVLEALELYNKLVNEAPVYSVYSKLHPPAHYPPASSGVPMQTYPVQSHGGNYMGQSIHQVTVAQSYSLGPDQIGPLRSLPPNVNSSVTAQPAQTSYLSTGQDTVSNPTYMNQNSNLQSATGTTAYTQQMGMSVDMSSYQNTTSNLPQLAGFPVTVPAHPVAQQHTNYHQQPLL
uniprot
proteins
function
FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
58164
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.
uniprot
proteins
protein_family
STAM family
uniprot
proteins
pubmed
10899310
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12551915
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15509564
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15882967
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000269|PubMed:12551915}; Peripheral membrane protein {ECO:0000269|PubMed:12551915}; Cytoplasmic side {ECO:0000269|PubMed:12551915}.
uniprot
proteins