Il17rc
entrez
171095
canonical
uniprot
Q8K4C2
canonical
ensembl
ENSMUSG00000030281
resolver
ensp
ENSMUSP00000055343
resolver
ensp
ENSMUSP00000231123
resolver
ensp
ENSMUSP00000231124
resolver
ensp
ENSMUSP00000337843
resolver
genesymbol
Il17rc
resolver
uniprot
G3X9C0
resolver
uniprot
Q8BPI5
resolver
uniprot
Q99J43
resolver
uniprot_entry
I17RC_MOUSE
resolver
uniprot_entry
Q8BPI5_MOUSE
resolver
uniprot_sec
G3X9C0
resolver
uniprot_sec
Q99J43
resolver
amino_acid_sequence
MPVSWFLLSLALGRNPVVVSLERLMEPQDTARCSLGLSCHLWDGDVLCLPGSLQSAPGPVLVPTRLQTELVLRCPQKTDCALCVRVVVHLAVHGHWAEPEEAGKSDSELQESRNASLQAQVVLSFQAYPIARCALLEVQVPADLVQPGQSVGSAVFDCFEASLGAEVQIWSYTKPRYQKELNLTQQLPDCRGLEVRDSIQSCWVLPWLNVSTDGDNVLLTLDVSEEQDFSFLLYLRPVPDALKSLWYKNLTGPQNITLNHTDLVPCLCIQVWSLEPDSERVEFCPFREDPGAHRNLWHIARLRVLSPGVWQLDAPCCLPGKVTLCWQAPDQSPCQPLVPPVPQKNATVNEPQDFQLVAGHPNLCVQVSTWEKVQLQACLWADSLGPFKDDMLLVEMKTGLNNTSVCALEPSGCTPLPSMASTRAARLGEELLQDFRSHQCMQLWNDDNMGSLWACPMDKYIHRRWVLVWLACLLLAAALFFFLLLKKDRRKAARGSRTALLLHSADGAGYERLVGALASALSQMPLRVAVDLWSRRELSAHGALAWFHHQRRRILQEGGVVILLFSPAAVAQCQQWLQLQTVEPGPHDALAAWLSCVLPDFLQGRATGRYVGVYFDGLLHPDSVPSPFRVAPLFSLPSQLPAFLDALQGGCSTSAGRPADRVERVTQALRSALDSCTSSSEAPGCCEEWDLGPCTTLE
uniprot
proteins
function
FUNCTION: Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:19144317, PubMed:27923703). Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:17911633, PubMed:20554964). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (By similarity). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (By similarity). Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:28813677). Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (PubMed:28813677). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (PubMed:32076265). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:20554964). Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (PubMed:27923703). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed:19144317). {ECO:0000250|UniProtKB:Q8NAC3, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:19144317, ECO:0000269|PubMed:20554964, ECO:0000269|PubMed:27923703, ECO:0000269|PubMed:28813677, ECO:0000269|PubMed:32076265}.
uniprot
proteins
mass_dalton
77148
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17911633
uniprot
proteins
pubmed
19144317
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20554964
uniprot
proteins
pubmed
26735852
uniprot
proteins
pubmed
27923703
uniprot
proteins
pubmed
28813677
uniprot
proteins
pubmed
32076265
uniprot
proteins
sequence_length
698
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:17911633}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:17911633}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:17911633}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:17911633}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 465..485; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins