Brms1
entrez
107392
canonical
uniprot
Q99N20
canonical
ensembl
ENSMUSG00000080268
resolver
ensp
ENSMUSP00000112266
resolver
ensp
ENSMUSP00000193956
resolver
ensp
ENSMUSP00000330207
resolver
enst
ENSMUST00000116567
resolver
genesymbol
Brms1
resolver
uniprot_entry
BRMS1_MOUSE
resolver
amino_acid_sequence
MPIQPSGKETEEMEAEGDSAAEMNGEADESEEERSGSQTESEEESSEMDDEDYERRRSECVSEMLDLEKQFSELKEKLFRERLSQLRLRLEEVGAERAPEYTEPLGGLQQSLKIRIQVAGIYKGFCLDVIRNKYECELQGAKQHLESEKMLLYDTLLGELQERIQRLEEDRQSLDISSEWWDDKLHSRSSSKAGDAMPPSKRKKAPLVSGPYIVYMLQEIDILEDWTAIKKARAAVSPQKRKADGP
uniprot
proteins
function
FUNCTION: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
28210
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation. {ECO:0000250}.
uniprot
proteins
protein_family
BRMS1 family
uniprot
proteins
pubmed
11774238
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
246
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. {ECO:0000250}.
uniprot
proteins