Slc5a4a
entrez
64452
canonical
uniprot
Q9ET37
canonical
ensembl
ENSMUSG00000020229
resolver
ensp
ENSMUSP00000020450
resolver
enst
ENSMUST00000020450
resolver
genesymbol
Slc5a4a
resolver
genesymbol_syn
Sglt3a
resolver
uniprot
G5E836
resolver
uniprot
Q8R479
resolver
uniprot_entry
S5A4A_MOUSE
resolver
uniprot_sec
G5E836
resolver
uniprot_sec
Q8R479
resolver
activity_regulation
ACTIVITY REGULATION: Not inhibited by phlorizin. {ECO:0000269|PubMed:22301059}.
uniprot
proteins
amino_acid_sequence
MASTASVSTSTASSELSSLSNNINNAADISVIVIYFVVVMAVGVWAMLKTNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSFALLLVLGWIFVPIYIKAGVMTMPEYLKKRFGGKRLQIYLSILFLFICVILTISADIFSGAIFIKLALGLNLYLAILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAIPSVVEGDNLTINSRCYTPQPDSFHIFRDPVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKNLSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASERELLIAGRLFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVFCKRANEQGAFWGLMVGLVMGLIRMIAEFSYGTGSCLAPSSCPKIICGVHYLYFAIILFFVCILVILGVSYLTKPIPDVHLHRLCWALRNSKEERIDLDAEDKEENGADDRTEEDQTEKPRGCLKKTCDLFCGLQRAEFKLTKVEEEALTDTTEKPFWRTVMNVNVILLLAVAAFFYGYFA
uniprot
proteins
function
FUNCTION: Does not function as sodium/D-glucose symporter (PubMed:22301059). Generates D-glucose-induced depolarization in a pH-dependent manner, with activity in acidic conditions (pH 5) but not neutral conditions (PubMed:22301059). {ECO:0000269|PubMed:22301059}.
uniprot
proteins
mass_dalton
71872
uniprot
proteins
mutagenesis
MUTAGEN 457; /note="E->Q: Confers sodium-dependent sugar transport activity not found in the wild type protein."; /evidence="ECO:0000269|PubMed:22301059
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
11042146
uniprot
proteins
pubmed
12969150
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22301059
uniprot
proteins
sequence_length
656
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:22301059}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..47; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 65..85; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 106..126; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..191; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 209..229; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 271..291; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 315..334; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 424..443; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 456..476; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 527..547; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 635..655; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins