LSM6
entrez
11157
canonical
uniprot
P62312
canonical
ensembl
ENSG00000164167
resolver
ensp
ENSP00000296581
resolver
ensp
ENSP00000420929
resolver
ensp
ENSP00000422392
resolver
ensp
ENSP00000427036
resolver
ensp
ENSP00000497311
resolver
ensp
ENSP00000520937
resolver
ensp
ENSP00000541455
resolver
ensp
ENSP00000541457
resolver
ensp
ENSP00000541458
resolver
ensp
ENSP00000541459
resolver
ensp
ENSP00000541460
resolver
ensp
ENSP00000541461
resolver
ensp
ENSP00000541463
resolver
ensp
ENSP00000541464
resolver
ensp
ENSP00000607896
resolver
ensp
ENSP00000607897
resolver
ensp
ENSP00000607898
resolver
ensp
ENSP00000607899
resolver
ensp
ENSP00000616439
resolver
ensp
ENSP00000616440
resolver
enst
ENST00000296581
resolver
enst
ENST00000502781
resolver
enst
ENST00000504181
resolver
enst
ENST00000515311
resolver
enst
ENST00000649747
resolver
enst
ENST00000850848
resolver
enst
ENST00000871396
resolver
enst
ENST00000871398
resolver
enst
ENST00000871399
resolver
enst
ENST00000871400
resolver
enst
ENST00000871401
resolver
enst
ENST00000871402
resolver
enst
ENST00000871404
resolver
enst
ENST00000871405
resolver
enst
ENST00000937837
resolver
enst
ENST00000937838
resolver
enst
ENST00000937839
resolver
enst
ENST00000937840
resolver
enst
ENST00000946380
resolver
enst
ENST00000946381
resolver
genesymbol
LSM6
resolver
hgnc
HGNC:17017
resolver
uniprot
Q4W5J5
resolver
uniprot
Q9Y4Y8
resolver
uniprot_entry
LSM6_HUMAN
resolver
uniprot_sec
Q4W5J5
resolver
uniprot_sec
Q9Y4Y8
resolver
amino_acid_sequence
MSLRKQTPSDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIALEQTEEYVNGQLKNKYGDAFIRGNNVLYISTQKRRM
uniprot
proteins
function
FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway (Probable). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166, ECO:0000305|PubMed:12515382}.
uniprot
proteins
mass_dalton
9128
uniprot
proteins
protein_family
SmF/LSm6 subfamily
uniprot
proteins
protein_family
SnRNP Sm proteins family
uniprot
proteins
pubmed
10369684
uniprot
proteins
pubmed
10523320
uniprot
proteins
pubmed
12515382
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
26912367
uniprot
proteins
pubmed
28781166
uniprot
proteins
sequence_length
80
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12515382}. Nucleus {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166}.
uniprot
proteins