Rrm2
entrez
362720
canonical
uniprot
Q4KLN6
canonical
ensembl
ENSRNOG00000054286
resolver
ensp
ENSRNOP00000073334
resolver
enst
ENSRNOT00000091551
resolver
genesymbol
Rrm2
resolver
uniprot
A0A8L2R734
resolver
uniprot_entry
A0A8L2R734_RAT
resolver
uniprot_entry
RIR2_RAT
resolver
amino_acid_sequence
MLSVRAPLATIADQQQLHLSPLKRLSLADKENTPPTLSSARVLASKAARRIFQDSAELESKAPTKPSIEEEPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDSKEREYLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEQRVKEIITNSVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFKVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSNSTENSFTLDADF
uniprot
proteins
ec_number
1.17.4.1
uniprot
proteins
function
FUNCTION: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Inhibits Wnt signaling (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
45039
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling (By similarity). Phosphorylated on Thr-33 by CDK1 and CDK2; predominantly in G2 and M phase (By similarity). {ECO:0000250|UniProtKB:P31350}.; PTM: Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex; leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:P31350}.
uniprot
proteins
protein_family
Ribonucleoside diphosphate reductase small chain family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P31350}. Nucleus {ECO:0000250|UniProtKB:P31350}. Note=Localized to the cytoplasm in S phase cells. May localize to the nucleus in G2 phase cells. {ECO:0000250|UniProtKB:P31350}.
uniprot
proteins