SUPV3L1
entrez
6832
canonical
uniprot
Q8IYB8
canonical
ensembl
ENSG00000156502
resolver
ensp
ENSP00000352678
resolver
enst
ENST00000359655
resolver
genesymbol
SUPV3L1
resolver
genesymbol_syn
SUV3
resolver
hgnc
HGNC:11471
resolver
uniprot
A8K301
resolver
uniprot
B7Z611
resolver
uniprot
O43630
resolver
uniprot_entry
B7Z611_HUMAN
resolver
uniprot_entry
SUV3_HUMAN
resolver
uniprot_sec
A8K301
resolver
uniprot_sec
O43630
resolver
activity_regulation
ACTIVITY REGULATION: Helicase activity toward DNA substrate is inhibited by micromolar concentrations of 5,6-dichloro-1-(beta-D-ribofuranosyl)benzotriazole (DRBT) and 4,5,6,7-tetrabromobenzotriazole (TBBT). Helicase activity toward RNA substrate is inhibited by elevated concentrations of TBBT. Inhibited by some ring-expanded nucleoside analogs. {ECO:0000269|PubMed:12694177, ECO:0000269|PubMed:14561097}.
uniprot
proteins
amino_acid_sequence
MSFSRALLWARLPAGRQAGHRAAICSALRPHFGPFPGVLGQVSVLATASSSASGGSKIPNTSLFVPLTVKPQGPSADGDVGAELTRPLDKNEVKKVLDKFYKRKEIQKLGADYGLDARLFHQAFISFRNYIMQSHSLDVDIHIVLNDICFGAAHADDLFPFFLRHAKQIFPVLDCKDDLRKISDLRIPPNWYPDARAMQRKIIFHSGPTNSGKTYHAIQKYFSAKSGVYCGPLKLLAHEIFEKSNAAGVPCDLVTGEERVTVQPNGKQASHVSCTVEMCSVTTPYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEVHLCGEPAAIDLVMELMYTTGEEVEVRDYKRLTPISVLDHALESLDNLRPGDCIVCFSKNDIYSVSRQIEIRGLESAVIYGSLPPGTKLAQAKKFNDPNDPCKILVATDAIGMGLNLSIRRIIFYSLIKPSINEKGERELEPITTSQALQIAGRAGRFSSRFKEGEVTTMNHEDLSLLKEILKRPVDPIRAAGLHPTAEQIEMFAYHLPDATLSNLIDIFVDFSQVDGQYFVCNMDDFKFSAELIQHIPLSLRVRYVFCTAPINKKQPFVCSSLLQFARQYSRNEPLTFAWLRRYIKWPLLPPKNIKDLMDLEAVHDVLDLYLWLSYRFMDMFPDASLIRDLQKELDGIIQDGVHNITKLIKMSETHKLLNLEGFPSGSQSRLSGTLKSQARRTRGTKALGSKATEPPSPDAGELSLASRLVQQGLLTPDMLKQLEKEWMTQQTEHNKEKTESGTHPKGTRRKKKEPDSD
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. {ECO:0000269|PubMed:12466530, ECO:0000269|PubMed:15096047, ECO:0000269|PubMed:17352692, ECO:0000269|PubMed:17961633, ECO:0000269|PubMed:18678873, ECO:0000269|PubMed:19509288, ECO:0000269|PubMed:19864255, ECO:0000269|PubMed:29967381}.
uniprot
proteins
mass_dalton
87991
uniprot
proteins
mutagenesis
MUTAGEN 207; /note="G->V: Abolishes ATPase and dsDNA and dsRNA helicase activities."; /evidence="ECO:0000269|PubMed:12466530"; MUTAGEN 213; /note="K->A,R: Abolishes ATPase activity. Abolishes helicase activity and reduces double-stranded RNA degradation. Does not abolish formation of the mitochondrial RNA-degrading complex."; /evidence="ECO:0000269|PubMed:15096047, ECO:0000269|PubMed:19509288"; MUTAGEN 576..581; /note="Missing: Does not abolish ATPase activity. Shows a loss of double-stranded RNA-binding, helicase and degrading activities."; /evidence="ECO:0000269|PubMed:19509288
uniprot
proteins
protein_family
Helicase family
uniprot
proteins
pubmed
10453991
uniprot
proteins
pubmed
12466530
uniprot
proteins
pubmed
12694177
uniprot
proteins
pubmed
14561097
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15096047
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16176273
uniprot
proteins
pubmed
17352692
uniprot
proteins
pubmed
17961633
uniprot
proteins
pubmed
18063578
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18678873
uniprot
proteins
pubmed
19509288
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19864255
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29967381
uniprot
proteins
sequence_length
786
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17352692}. Mitochondrion matrix {ECO:0000269|PubMed:12466530, ECO:0000269|PubMed:17352692, ECO:0000269|PubMed:19864255}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578}.
uniprot
proteins