ATP5IF1
entrez
93974
canonical
uniprot
Q9UII2
canonical
ensembl
ENSG00000130770
resolver
ensembl
ENSG00000285390
resolver
ensp
ENSP00000335203
resolver
ensp
ENSP00000435579
resolver
ensp
ENSP00000437337
resolver
genesymbol
ATP5IF1
resolver
genesymbol_syn
ATPI
resolver
genesymbol_syn
ATPIF1
resolver
hgnc
HGNC:871
resolver
uniprot
Q5JXL8
resolver
uniprot
Q6IAQ7
resolver
uniprot
Q9BSL9
resolver
uniprot_entry
ATIF1_HUMAN
resolver
uniprot_sec
Q5JXL8
resolver
uniprot_sec
Q6IAQ7
resolver
uniprot_sec
Q9BSL9
resolver
amino_acid_sequence
MAVTALAARTWLGVWGVRTMQARGFGSDQSENVDRGAGSIREAGGAFGKREQAEEERYFRAQSREQLAALKKHHEEEIVHHKKEIERLQKEIERHKQKIKMLKHDD
uniprot
proteins
function
FUNCTION: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix (PubMed:35926043). Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. {ECO:0000269|PubMed:12110673, ECO:0000269|PubMed:15528193, ECO:0000269|PubMed:19559621, ECO:0000269|PubMed:23135403, ECO:0000269|PubMed:35926043}.
uniprot
proteins
mass_dalton
12249
uniprot
proteins
post_translational_modification
PTM: Exhibits variability in chain length, mitochondria have distinct pools of protein cleaved after the 24th, 25th, and 26th amino acid.
uniprot
proteins
protein_family
ATPase inhibitor family
uniprot
proteins
pubmed
10664857
uniprot
proteins
pubmed
12110673
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15528193
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19559621
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19892738
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23135403
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
35926043
uniprot
proteins
sequence_length
106
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12110673}.
uniprot
proteins