NUAK1
entrez
9891
canonical
uniprot
O60285
canonical
ensembl
ENSG00000074590
resolver
ensp
ENSP00000261402
resolver
genesymbol
NUAK1
resolver
genesymbol_syn
ARK5
resolver
genesymbol_syn
KIAA0537
resolver
genesymbol_syn
OMPHK1
resolver
hgnc
HGNC:14311
resolver
uniprot
A7MD39
resolver
uniprot
Q96KA8
resolver
uniprot_entry
NUAK1_HUMAN
resolver
uniprot_sec
A7MD39
resolver
uniprot_sec
Q96KA8
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-211. Activated by phosphorylation at Ser-600 AKT1 during glucose starvation; the relevance of such activation in normal cells is however unsure. {ECO:0000269|PubMed:14976552}.
uniprot
proteins
amino_acid_sequence
MEGAAAPVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAKPTTSEVMLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMGSSIPSPSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPALVSPEMPTLESLSEPGVPAEGLSRSYSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRSCVSAENFLQIQDFEGLQNRPRPQYLKRYRNRLADSSFSLLTDMDDVTQVYKQALEICSKLN
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}.
uniprot
proteins
mass_dalton
74305
uniprot
proteins
mutagenesis
MUTAGEN 84; /note="K->A: Abolishes kinase activity and ability to induce senescence."; /evidence="ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:21317932"; MUTAGEN 211; /note="T->A: Prevents phosphorylation and activation by STK11/LKB1 complex. Abolishes ability to induce senescence."; /evidence="ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:21317932"; MUTAGEN 400..401; /note="IL->KK: Abolishes interaction with PPP1CB and ability to regulate myosin PP1 activity."; /evidence="ECO:0000269|PubMed:20354225"; MUTAGEN 600; /note="S->A: Abrogates phosphorylation by PKB/AKT1. Does not affect ability to induce senescence."; /evidence="ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:19927127
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X. {ECO:0000269|PubMed:18254724}.; PTM: Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not dephosphorylated by the myosin PP1 complex when regulating its activity, due to the presence of PPP1R12A, which prevents myosin PP1 from dephosphorylating NUAK1. Phosphorylated by STK38L upon stimulation with IGF1. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:20354225}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SNF1 subfamily
uniprot
proteins
pubmed
12409306
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14976552
uniprot
proteins
pubmed
14982852
uniprot
proteins
pubmed
15060171
uniprot
proteins
pubmed
15273717
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16044163
uniprot
proteins
pubmed
16424013
uniprot
proteins
pubmed
16488889
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18254724
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19927127
uniprot
proteins
pubmed
20354225
uniprot
proteins
pubmed
21317932
uniprot
proteins
pubmed
25329316
uniprot
proteins
pubmed
9628581
uniprot
proteins
sequence_length
661
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21317932}. Cytoplasm {ECO:0000269|PubMed:21317932}.
uniprot
proteins