Scnn1a
entrez
20276
canonical
uniprot
Q61180
canonical
ensembl
ENSMUSG00000030340
resolver
ensp
ENSMUSP00000080164
resolver
enst
ENSMUST00000081440
resolver
genesymbol
Scnn1a
resolver
uniprot
F8WGE5
resolver
uniprot
Q3USG4
resolver
uniprot
Q9WU37
resolver
uniprot_entry
F8WGE5_MOUSE
resolver
uniprot_entry
Q3USG4_MOUSE
resolver
uniprot_entry
SCNNA_MOUSE
resolver
uniprot_sec
Q9WU37
resolver
activity_regulation
ACTIVITY REGULATION: Originally identified and characterized by its inhibition by the diuretic drug amiloride. {ECO:0000269|PubMed:10409305, ECO:0000269|PubMed:15007080}.
uniprot
proteins
amino_acid_sequence
MLDHTRAPELNLDLDLDVSNSPKGSMKGNNFKEQDLCPPLPMQGLGKGDKREEQALGPEPSEPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFALLFEEYFSYPVSLNINLNSDKLVFPAVTVCTLNPYRYTEIKEDLEELDRITEQTLFDLYKYNSSYTRQAGGRRRSTRDLRGALPHPLQRLRTPPPPNPARSARSASSSVRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPDTSPALEEEALGSFIFTCRFNQAPCNQANYSQFHHPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSWGYCYYKLQAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLIMLLHRFRSRYWSPGRGARGAREVASTPASSFPSRFCPHPTSPPPSLPQQGTTPPLALTAPPPAYATLGPSASPLDSAVPGSSACAPAMAL
uniprot
proteins
function
FUNCTION: This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:10409305, PubMed:8589728, PubMed:9326675, PubMed:15007080). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:24480829, PubMed:8589728, PubMed:9326675). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (PubMed:9326675). Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance (PubMed:8589728). {ECO:0000269|PubMed:10409305, ECO:0000269|PubMed:15007080, ECO:0000269|PubMed:24480829, ECO:0000269|PubMed:8589728, ECO:0000269|PubMed:9326675}.
uniprot
proteins
mass_dalton
78893
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Can be ubiquitinated at multiple sites and undergo monoubiquitination and polyubiquitination. Ubiquitination by NEDD4 or NEDD4L inhibits the ENaC channel through endocytosis, intracellular retention and degradation of its individual subunits. {ECO:0000269|PubMed:11244092, ECO:0000269|PubMed:12424229, ECO:0000269|PubMed:15123669}.; PTM: ENaC is activated through the proteolytic maturation of its subunits. Furin cleaves the SCNN1A subunit, which results in a stepwise increase in the open probability of the channel due to the release of an inhibitory tract (PubMed:18650438). BPIFA1, which is recruited by the SCNN1B subunit, prevents the proteolytic activation of ENaC (By similarity). {ECO:0000250|UniProtKB:P37088, ECO:0000269|PubMed:18650438}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:P37089}.
uniprot
proteins
protein_family
Amiloride-sensitive sodium channel (TC 1.A.6) family
uniprot
proteins
protein_family
SCNN1A subfamily
uniprot
proteins
pubmed
10409305
uniprot
proteins
pubmed
11244092
uniprot
proteins
pubmed
12424229
uniprot
proteins
pubmed
15007080
uniprot
proteins
pubmed
15123669
uniprot
proteins
pubmed
18650438
uniprot
proteins
pubmed
22207244
uniprot
proteins
pubmed
24480829
uniprot
proteins
pubmed
30659401
uniprot
proteins
pubmed
8589728
uniprot
proteins
pubmed
9284273
uniprot
proteins
pubmed
9326675
uniprot
proteins
sequence_length
699
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P37089}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P37089}. Cell projection, cilium {ECO:0000250|UniProtKB:P37088}. Cytoplasmic granule {ECO:0000250|UniProtKB:P37088}. Cytoplasm {ECO:0000250|UniProtKB:P37088}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:P37089}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:P37089}. Note=In the oviduct and bronchus, located on cilia in multi-ciliated cells. In endometrial non-ciliated epithelial cells, restricted to apical surfaces. In epidermis, located nearly uniformly in the cytoplasm in a granular distribution. In sebaceous glands, observed only in the cytoplasmic space in between the lipid vesicles. In eccrine sweat glands, mainly located at the apical surface of the cells facing the lumen. In skin, in arrector pili muscle cells and in adipocytes, located in the cytoplasm and colocalized with actin fibers. In spermatogonia, spermatocytes and round spermatids, located in the cytoplasm. Prior to spermiation, location shifts from the cytoplasm to the spermatid tail. In spermatozoa, localizes at the acrosome and the central region of the sperm flagellum. {ECO:0000250|UniProtKB:P37088, ECO:0000250|UniProtKB:P37089}.
uniprot
proteins
transmembrane_region
TRANSMEM 111..131; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 590..610; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins