Prkra
entrez
23992
canonical
uniprot
Q9WTX2
canonical
ensembl
ENSMUSG00000002731
resolver
ensp
ENSMUSP00000002808
resolver
ensp
ENSMUSP00000286982
resolver
ensp
ENSMUSP00000359056
resolver
enst
ENSMUST00000002808
resolver
genesymbol
Prkra
resolver
genesymbol_syn
Rax
resolver
uniprot
Q9CZB7
resolver
uniprot_entry
PRKRA_MOUSE
resolver
uniprot_sec
Q9CZB7
resolver
amino_acid_sequence
MSHSRHRAEAPPLQREDSGTFSLGKMITAKPGKTPIQVLHEYGMKTKNIPVYECERSDVQVHVPTFTFRVTVGDITCTGEGTSKKLAKHRAAEAAINILKANASICFAVPDPLMPDPSKQPKNQLNPIGSLQELAIHHGWRLPEYTLSQEGGPAHKREYTTICRLESFMETGKGASKKQAKRNAAEKFLAKFSNISPENHISLTNVVGHSLGCTWHSLRNSPGEKINLLKRSLLSLPNTDYIQLLSEIASEQGFNITYLDIEELSANGQYQCLAELSTSPITVCHGSGISCGNAQSDAAHNALQYLKIIAERK
uniprot
proteins
function
FUNCTION: Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1 (By similarity). Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner. May function as regulator of gastric epithelial differentiation (PubMed:33479180). {ECO:0000250, ECO:0000269|PubMed:10336432, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:33479180}.
uniprot
proteins
mass_dalton
34371
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-246 in unstressed cells and at Ser-287 in stressed cells. Phosphorylation at Ser-246 appears to be a prerequisite for subsequent phosphorylation at Ser-287. Phosphorylation at Ser-246 and Ser-287 are necessary for activation of EIF2AK2/PKR under conditions of stress (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
PRKRA family
uniprot
proteins
pubmed
10336432
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22214662
uniprot
proteins
pubmed
33479180
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm {ECO:0000250}.
uniprot
proteins