Olig1
entrez
60394
canonical
uniprot
Q9WUQ3
canonical
ensembl
ENSRNOG00000028648
resolver
ensembl
ENSRNOG00055017462
resolver
ensembl
ENSRNOG00060021302
resolver
ensembl
ENSRNOG00065006879
resolver
ensp
ENSRNOP00000002827
resolver
ensp
ENSRNOP00055023737
resolver
ensp
ENSRNOP00060030369
resolver
ensp
ENSRNOP00065007928
resolver
enst
ENSRNOT00000002827
resolver
enst
ENSRNOT00055029547
resolver
enst
ENSRNOT00060036859
resolver
enst
ENSRNOT00065010711
resolver
genesymbol
Olig1
resolver
uniprot_entry
OLIG1_RAT
resolver
amino_acid_sequence
MYYAVSQARVNAAPATMLRPQRPGDVQLGASLYELVGYRQPPISSSSSTSSSSTASLLPKPAREKPEAPLAEPRGPAPESGGARADAKEEQQQQQLRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLGSSLQELRRALGDGAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPETLRPTKYLSLALDEPPCGQFALPAGGAGSPGLCSCAVCKFPHLVPAGLGLAAVQAQFSK
uniprot
proteins
function
FUNCTION: Orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis. In cooperation with OLIG2, activates oligodendrocyte precursor cells (OPCs) formation while repressing the generation of olfactory bulb interneuron intermediate progenitors (OBIN) through transcriptional regulation of GSX2. Mechanistically, binds and silences multiple conserved enhancer elements of GSX2. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube. {ECO:0000250|UniProtKB:Q9JKN5}.; FUNCTION: Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube. {ECO:0000250|UniProtKB:Q9JKN5}.
uniprot
proteins
mass_dalton
27239
uniprot
proteins
post_translational_modification
PTM: 'Lys-63'-linked polyubiquitinated by RNF220; leading to stabilization during oligodendroglial development and myelination. {ECO:0000250|UniProtKB:Q8TAK6}.
uniprot
proteins
pubmed
10719888
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
uniprot
proteins