DPY19L1
entrez
23333
canonical
uniprot
Q2PZI1
canonical
ensembl
ENSG00000173852
resolver
ensp
ENSP00000308695
resolver
ensp
ENSP00000490722
resolver
ensp
ENSP00000598219
resolver
ensp
ENSP00000614904
resolver
enst
ENST00000638088
resolver
enst
ENST00000944845
resolver
genesymbol
DPY19L1
resolver
genesymbol_syn
GA0500
resolver
genesymbol_syn
KIAA0877
resolver
hgnc
HGNC:22205
resolver
uniprot
A0A1B0GW05
resolver
uniprot
O94954
resolver
uniprot
Q4G151
resolver
uniprot_entry
A0A1B0GW05_HUMAN
resolver
uniprot_entry
D19L1_HUMAN
resolver
uniprot_sec
O94954
resolver
uniprot_sec
Q4G151
resolver
amino_acid_sequence
MEGRPPPEGRPPPRPRTGRAPRGRRRAVFAAVLHWSHITHLFENDRHFSHLSTLEREMAFRTEMGLYYSYFKTIVEAPSFLNGVWMIMNDKLTEYPLVINTLKRFNLYPEVILASWYRIYTKIMDLIGIQTKICWTVTRGEGLSPIESCEGLGDPACFYVAVIFILNGLMMALFFIYGTYLSGSRLGGLVTVLCFFFNHGECTRVMWTPPLRESFSYPFLVLQMLLVTHILRATKLYRGSLIALCISNVFFMLPWQFAQFVLLTQIASLFAVYVVGYIDICKLRKIIYIHMISLALCFVLMFGNSMLLTSYYASSLVIIWGILAMKPHFLKINVSELSLWVIQGCFWLFGTVILKYLTSKIFGIADDAHIGNLLTSKFFSYKDFDTLLYTCAAEFDFMEKETPLRYTKTLLLPVVLVVFVAIVRKIISDMWGVLAKQQTHVRKHQFDHGELVYHALQLLAYTALGILIMRLKLFLTPHMCVMASLICSRQLFGWLFCKVHPGAIVFAILAAMSIQGSANLQTQWNIVGEFSNLPQEELIEWIKYSTKPDAVFAGAMPTMASVKLSALRPIVNHPHYEDAGLRARTKIVYSMYSRKAAEEVKRELIKLKVNYYILEESWCVRRSKPGCSMPEIWDVEDPANAGKTPLCNLLVKDSKPHFTTVFQNSVYKVLEVVKE
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
function
FUNCTION: C-mannosyltransferase that mediates the C-mannosylation tryptophan residues on target proteins. The reaction occurs on the luminal side of the endoplasmic reticulum and involves the transfer of a mannose unit from a dolichylphosphate mannose (Dol-P-Man) donor to an acceptor protein containing a WxxW consensus sequence (By similarity). C-mannosylates the first two tryptophans in the WxxWxxWxxC motif in thrombospondin (TSP) type-1 of UNC5A (By similarity). Regulates neurite extension during development (By similarity). {ECO:0000250|UniProtKB:A6X919}.
uniprot
proteins
mass_dalton
77319
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:A6X919}.
uniprot
proteins
protein_family
Dpy-19 family
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16526957
uniprot
proteins
sequence_length
675
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A6X919}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 66..88; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 156..176; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 186..208; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..254; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 260..279; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 286..303; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 309..325; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 334..354; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 414..434; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 449..469; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 491..511; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins