TNFRSF17
entrez
608
canonical
uniprot
Q02223
canonical
ensembl
ENSG00000048462
resolver
ensp
ENSP00000053243
resolver
genesymbol
TNFRSF17
resolver
genesymbol_syn
BCM
resolver
genesymbol_syn
BCMA
resolver
hgnc
HGNC:11913
resolver
uniprot
Q2TQ40
resolver
uniprot_entry
TNR17_HUMAN
resolver
uniprot_sec
Q2TQ40
resolver
amino_acid_sequence
MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCLGLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLEYTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKSISAR
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2. {ECO:0000269|PubMed:1396583}.
uniprot
proteins
function
FUNCTION: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. {ECO:0000269|PubMed:10801128, ECO:0000269|PubMed:10903733, ECO:0000269|PubMed:10973284}.
uniprot
proteins
mass_dalton
20165
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
10801128
uniprot
proteins
pubmed
10903733
uniprot
proteins
pubmed
10908663
uniprot
proteins
pubmed
10973284
uniprot
proteins
pubmed
11528522
uniprot
proteins
pubmed
12721620
uniprot
proteins
pubmed
1396583
uniprot
proteins
pubmed
15542592
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17825416
uniprot
proteins
pubmed
8165126
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures.
uniprot
proteins
transmembrane_region
TRANSMEM 55..77; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins