GAD2
entrez
2572
canonical
uniprot
Q05329
canonical
ensembl
ENSG00000136750
resolver
ensp
ENSP00000259271
resolver
ensp
ENSP00000365437
resolver
enst
ENST00000259271
resolver
enst
ENST00000376261
resolver
genesymbol
GAD2
resolver
genesymbol_syn
GAD65
resolver
hgnc
HGNC:4093
resolver
uniprot
Q5VZ30
resolver
uniprot
Q9UD87
resolver
uniprot_entry
DCE2_HUMAN
resolver
uniprot_entry
Q5VZ30_HUMAN
resolver
uniprot_sec
Q9UD87
resolver
amino_acid_sequence
MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGGSQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEYGTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL
uniprot
proteins
ec_number
4.1.1.15
uniprot
proteins
function
FUNCTION: Catalyzes the production of GABA. {ECO:0000305|PubMed:8999827}.
uniprot
proteins
mass_dalton
65411
uniprot
proteins
mutagenesis
MUTAGEN 3..13; /note="SPGSGFWSFGS->APGAGFWAFGA: No effect on glutamate decarboxylase activity."; /evidence="ECO:0000269|PubMed:8999827
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; which does not affect kinetic parameters or subcellular location. {ECO:0000269|PubMed:8999827}.; PTM: Palmitoylated; which is required for presynaptic clustering. {ECO:0000269|PubMed:12356867}.
uniprot
proteins
protein_family
Group II decarboxylase family
uniprot
proteins
pubmed
10775108
uniprot
proteins
pubmed
12356867
uniprot
proteins
pubmed
1549570
uniprot
proteins
pubmed
17384644
uniprot
proteins
pubmed
1924293
uniprot
proteins
pubmed
7680313
uniprot
proteins
pubmed
8088791
uniprot
proteins
pubmed
8243826
uniprot
proteins
pubmed
8999827
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12356867}. Cytoplasmic vesicle {ECO:0000269|PubMed:12356867}. Presynaptic cell membrane {ECO:0000269|PubMed:12356867}; Lipid-anchor {ECO:0000269|PubMed:12356867}. Golgi apparatus membrane {ECO:0000269|PubMed:12356867}; Peripheral membrane protein {ECO:0000269|PubMed:12356867}; Cytoplasmic side {ECO:0000269|PubMed:12356867}. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
uniprot
proteins