GNL2
entrez
29889
canonical
uniprot
Q13823
canonical
ensembl
ENSG00000134697
resolver
ensp
ENSP00000362153
resolver
enst
ENST00000373062
resolver
genesymbol
GNL2
resolver
genesymbol_syn
NGP1
resolver
hgnc
HGNC:29925
resolver
uniprot
Q5T0F3
resolver
uniprot
Q9BWN7
resolver
uniprot_entry
NOG2_HUMAN
resolver
uniprot_entry
Q5T0F3_HUMAN
resolver
uniprot_sec
Q9BWN7
resolver
amino_acid_sequence
MVKPKYKGRSTINPSKASTNPDRVQGAGGQNMRDRATIRRLNMYRQKERRNSRGKIIKPLQYQSTVASGTVARVEPNIKWFGNTRVIKQSSLQKFQEEMDTVMKDPYKVVMKQSKLPMSLLHDRIRPHNLKVHILDTESFETTFGPKSQRKRPNLFASDMQSLIENAEMSTESYDQGKDRDLVTEDTGVRNEAQEEIYKKGQSKRIWGELYKVIDSSDVVVQVLDARDPMGTRSPHIETYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDYPTLAFHASLTNPFGKGAFIQLLRQFGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIKSPEDHIGAVLERAKPEYISKTYKIDSWENAEDFLEKLAFRTGKLLKGGEPDLQTVGKMVLNDWQRGRIPFFVKPPNAEPLVAPQLLPSSSLEVVPEAAQNNPGEEVTETAGEGSESIIKEETEENSHCDANTEMQQILTRVRQNFGKINVVPQFSGDDLVPVEVSDLEEELESFSDEEEEEQEQQRDDAEESSSEPEEENVGNDTKAVIKALDEKIAKYQKFLDKAKAKKFSAVRISKGLSEKIFAKPEEQRKTLEEDVDDRAPSKKGKKRKAQREEEQEHSNKAPRALTSKERRRAVRQQRPKKVGVRYYETHNVKNRNRNKKKTNDSEGQKHKRKKFRQKQ
uniprot
proteins
function
FUNCTION: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (PubMed:32669547). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195). {ECO:0000269|PubMed:26203195, ECO:0000269|PubMed:32669547}.
uniprot
proteins
mass_dalton
83655
uniprot
proteins
mutagenesis
MUTAGEN 33..35; /note="RDR->ADA: Diffused nuclear localization, loss of nucleolar localization."; /evidence="ECO:0000269|PubMed:21495629"; MUTAGEN 39..40; /note="RR->AA: Diffused nuclear localization, loss of nucleolar localization."; /evidence="ECO:0000269|PubMed:21495629"; MUTAGEN 39..40; /note="RR->AA: No effect on nucleolar localization."; /evidence="ECO:0000269|PubMed:21495629"; MUTAGEN 49..50; /note="RR->AA: Diffused nuclear localization, loss of nucleolar localization."; /evidence="ECO:0000269|PubMed:21495629"; MUTAGEN 227..229; /note="RDP->AAA: Loss of GTP-binding. Efficient localization to the nucleus, but excluded from nucleoli."; /evidence="ECO:0000269|PubMed:21495629"; MUTAGEN 258; /note="D->A: Loss of GTP-binding. Punctate pattern throughout the nucleus, including nucleoli."; /evidence="ECO:0000269|PubMed:21495629"; MUTAGEN 323; /note="K->A: No effect on GTP-binding, nor on nucleolar localization."; /evidence="ECO:0000269|PubMed:21495629"; MUTAGEN 324; /note="S->A: No effect on GTP-binding, nor on nucleolar localization."; /evidence="ECO:0000269|PubMed:21495629"; MUTAGEN 325; /note="S->A: No effect on GTP-binding, nor on nucleolar localization."; /evidence="ECO:0000269|PubMed:21495629"; MUTAGEN 343..345; /note="GET->AEA: No effect on GTP-binding, nor on nucleolar localization."; /evidence="ECO:0000269|PubMed:21495629"; MUTAGEN 363..364; /note="PG->AA: No effect on GTP-binding, nor on nucleolar localization."; /evidence="ECO:0000269|PubMed:21495629"; MUTAGEN 463; /note="P->A: No effect on nucleolar localization; when associated with A-475."; /evidence="ECO:0000269|PubMed:21495629"; MUTAGEN 475; /note="P->A: No effect on nucleolar localization; when associated with A-463."; /evidence="ECO:0000269|PubMed:21495629"; MUTAGEN 682..684; /note="RRR->AAA: No effect on nucleolar localization. Predominantly cytoplasmic, with some nucleolar staining; when associated with 711-AAA-713. Diffused localization to both cytoplasm and nucleus; when associated with 711-AAA-713 and 724-AAA-726."; /evidence="ECO:0000269|PubMed:21495629"; MUTAGEN 711..713; /note="KKK->AAA: No effect on nucleolar localization Predominantly cytoplasmic, with some nucleolar staining; when associated with 682-AAA-684. Strong nucleolar localization, with some cytoplasmic staining; when associated with 724-AAA-726. Diffused localization to both cytoplasm and nucleus; when associated with 682-AAA-684 and 724-AAA-726."; /evidence="ECO:0000269|PubMed:21495629"; MUTAGEN 724..726; /note="RKK->AAA: No effect on nucleolar localization. Strong nucleolar localization, with some cytoplasmic staining; when associated with 711-AAA-713. Diffused localization to both cytoplasm and nucleus; when associated with 682-AAA-684 and 711-AAA-713."; /evidence="ECO:0000269|PubMed:21495629
uniprot
proteins
protein_family
NOG2 subfamily
uniprot
proteins
protein_family
TRAFAC class YlqF/YawG GTPase family
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21495629
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
26203195
uniprot
proteins
pubmed
32669547
uniprot
proteins
pubmed
8822211
uniprot
proteins
sequence_length
731
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:21495629}.
uniprot
proteins