Tfam
entrez
21780
canonical
uniprot
P40630
canonical
ensembl
ENSMUSG00000003923
resolver
ensp
ENSMUSP00000090086
resolver
ensp
ENSMUSP00000101072
resolver
genesymbol
Tfam
resolver
genesymbol_syn
Hmgts
resolver
uniprot
P97894
resolver
uniprot
P97906
resolver
uniprot
Q543I8
resolver
uniprot
Q9DBM9
resolver
uniprot_entry
TFAM_MOUSE
resolver
uniprot_sec
P97894
resolver
uniprot_sec
P97906
resolver
uniprot_sec
Q543I8
resolver
uniprot_sec
Q9DBM9
resolver
amino_acid_sequence
MALFRGMWSVLKALGRTGVEMCAGCGGRIPSSISLVCIPKCFSSMGSYPKKPMSSYLRFSTEQLPKFKAKHPDAKLSELVRKIAALWRELPEAEKKVYEADFKAEWKAYKEAVSKYKEQLTPSQLMGMEKEARQRRLKKKALVKRRELILLGKPKRPRSAYNIYVSESFQEAKDDSAQGKLKLVNEAWKNLSPEEKQAYIQLAKDDRIRYDNEMKSWEEQMAEVGRSDLIRRSVKRSGDISEH
uniprot
proteins
function
FUNCTION: [Isoform Mitochondrial]: Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (By similarity). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (By similarity). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (By similarity). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (By similarity). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (By similarity). Is able to unwind DNA (By similarity). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (By similarity). Required for maintenance of normal levels of mitochondrial DNA (PubMed:9500544). May play a role in organizing and compacting mitochondrial DNA (PubMed:17581862). {ECO:0000250|UniProtKB:Q00059, ECO:0000269|PubMed:17581862, ECO:0000269|PubMed:9500544}.; FUNCTION: [Isoform Nuclear]: May also function as a transcriptional activator or may have a structural role in the compaction of nuclear DNA during spermatogenesis. {ECO:0000269|PubMed:8673128}.
uniprot
proteins
mass_dalton
27988
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PKA within the HMG box 1 impairs DNA binding and promotes degradation by the AAA+ Lon protease. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17581862
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
8321234
uniprot
proteins
pubmed
8673128
uniprot
proteins
pubmed
9500544
uniprot
proteins
sequence_length
243
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion {ECO:0000250|UniProtKB:Q00059}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:Q00059}.; SUBCELLULAR LOCATION: [Isoform Nuclear]: Nucleus {ECO:0000269|PubMed:8673128}.
uniprot
proteins