Slc47a1
entrez
360539
canonical
uniprot
Q5I0E9
canonical
ensembl
ENSRNOG00000057404
resolver
ensp
ENSRNOP00000074897
resolver
genesymbol
Slc47a1
resolver
genesymbol_syn
Mate1
resolver
uniprot
Q0KKE7
resolver
uniprot_entry
S47A1_RAT
resolver
uniprot_sec
Q0KKE7
resolver
amino_acid_sequence
MEVLEEPAPGPGGADAAERRGLRRLLLSGFQEELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIAANLVNALANYLFLHQLHLGVMGSALANTISQFALAIFLFLYILWRKLHHATWGGWSWECLQDWASFLQLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPAGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHLFEALACTCGGVLRGTGNQKVGAIVNAIGYYVIGLPIGISLMFVAKLGVIGLWSGIIICSVCQTSCFLVFIARLNWKLACQQAQVHANLKVNVALNSAVSQEPAHPVGPESHGEIMMTDLEKKDEIQLDQQMNQQQALPVHPKDSNKLSGKQLALRRGLLFLGVVLVLVGGILVRVYIRTE
uniprot
proteins
function
FUNCTION: Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:17047166). Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16850272, PubMed:16928787, PubMed:17047166, PubMed:17327464, PubMed:17582384). Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16850272, PubMed:16928787, PubMed:17047166, PubMed:17327464, PubMed:17582384). May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). {ECO:0000269|PubMed:16850272, ECO:0000269|PubMed:16928787, ECO:0000269|PubMed:17047166, ECO:0000269|PubMed:17327464, ECO:0000269|PubMed:17582384, ECO:0000305|PubMed:17616214}.
uniprot
proteins
mass_dalton
61440
uniprot
proteins
mutagenesis
MUTAGEN 62; /note="C->G,F,L,M: Reduction of in TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 64; /note="H->Q: No change in TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 95; /note="C->G: No change in TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 110; /note="H->Q: No change in TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 125; /note="C->G: No change in TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 126; /note="C->G,F,L,M: Reduction of TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 129; /note="C->G: Modest reduction of TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 209; /note="H->Q: No change in TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 240; /note="H->Q: No change in TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 251; /note="C->G: No change in TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 270; /note="C->G: No change in TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 356; /note="C->G: Modest reduction of TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 385; /note="H->Q,F,L,M,P,S,W: Important reduction of TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 392; /note="C->G: Modest reduction of TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 444; /note="C->G: No change in TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 451; /note="C->G: Modest reduction of TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 465; /note="C->G: No change in TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 471; /note="H->Q: No change in TEA uptake."; /evidence="ECO:0000269|PubMed:17327464"; MUTAGEN 490; /note="H->Q: No change in TEA uptake."; /evidence="ECO:0000269|PubMed:17327464
uniprot
proteins
protein_family
Multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16850272
uniprot
proteins
pubmed
16928787
uniprot
proteins
pubmed
17047166
uniprot
proteins
pubmed
17296166
uniprot
proteins
pubmed
17327464
uniprot
proteins
pubmed
17582384
uniprot
proteins
pubmed
17616214
uniprot
proteins
sequence_length
566
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17296166, ECO:0000269|PubMed:17327464}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q96FL8}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the plasma membrane; at the brush border membranes of the proximal tubules (kidney) and at the bile caniculi (liver). {ECO:0000250|UniProtKB:Q96FL8}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..57; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 152..172; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 176..196; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 216..236; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 257..276; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 295..315; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 336..356; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 370..390; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 409..429; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 437..457; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 543..563; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins