SPN
entrez
6693
canonical
uniprot
P16150
canonical
ensembl
ENSG00000197471
resolver
ensp
ENSP00000353238
resolver
ensp
ENSP00000378787
resolver
ensp
ENSP00000455266
resolver
ensp
ENSP00000498852
resolver
ensp
ENSP00000528240
resolver
ensp
ENSP00000528241
resolver
ensp
ENSP00000633458
resolver
enst
ENST00000360121
resolver
enst
ENST00000395389
resolver
enst
ENST00000563039
resolver
enst
ENST00000652691
resolver
enst
ENST00000858181
resolver
enst
ENST00000858182
resolver
enst
ENST00000963399
resolver
genesymbol
SPN
resolver
genesymbol_syn
CD43
resolver
hgnc
HGNC:11249
resolver
uniprot
A8K9B1
resolver
uniprot_entry
LEUK_HUMAN
resolver
uniprot_sec
A8K9B1
resolver
amino_acid_sequence
MATLLLLLGVLVVSPDALGSTTAVQTPTSGEPLVSTSEPLSSKMYTTSITSDPKADSTGDQTSALPPSTSINEGSPLWTSIGASTGSPLPEPTTYQEVSIKMSSVPQETPHATSHPAVPITANSLGSHTVTGGTITTNSPETSSRTSGAPVTTAASSLETSRGTSGPPLTMATVSLETSKGTSGPPVTMATDSLETSTGTTGPPVTMTTGSLEPSSGASGPQVSSVKLSTMMSPTTSTNASTVPFRNPDENSRGMLPVAVLVALLAVIVLVALLLLWRRRQKRRTGALVLSRGGKRNGVVDAWAGPAQVPEEGAVTVTVGGSGGDKGSGFPDGEGSSRRPTLTTFFGRRKSRQGSLAMEELKSGSGPSLKGEEEPLVASEDGAVDAPAPDEPEGGDGAAP
uniprot
proteins
function
FUNCTION: Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity). {ECO:0000250|UniProtKB:P15702, ECO:0000269|PubMed:18036228, ECO:0000269|PubMed:24328034}.; FUNCTION: [CD43 cytoplasmic tail]: Protects cells from apoptotic signals, promoting cell survival. {ECO:0000250|UniProtKB:P15702}.
uniprot
proteins
mass_dalton
40322
uniprot
proteins
mutagenesis
MUTAGEN 282..283; /note="KR->PG: Reduced nuclear localization. Loss of nuclear localization; when associated with 295-P-G-296."; /evidence="ECO:0000269|PubMed:15003504"; MUTAGEN 295..296; /note="KR->PG: Reduced nuclear localization. Loss of nuclear localization; when associated with 282-P-G-283."; /evidence="ECO:0000269|PubMed:15003504
uniprot
proteins
post_translational_modification
PTM: Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures. {ECO:0000269|PubMed:1731338}.; PTM: Phosphorylation at Ser-355 is regulated by chemokines, requires its association with ERM proteins (EZR, RDX and MSN) and is essential for its function in the regulation of T-cell trafficking to lymph nodes. {ECO:0000250|UniProtKB:P15702}.; PTM: Has a high content of sialic acid and O-linked carbohydrate structures.; PTM: Cleavage by CTSG releases its extracellular domain and triggers its intramembrane proteolysis by gamma-secretase releasing the CD43 cytoplasmic tail chain (CD43-ct) which translocates to the nucleus. {ECO:0000269|PubMed:15540986, ECO:0000269|PubMed:18586676}.; PTM: [CD43 cytoplasmic tail]: Sumoylated.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15003504
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15540986
uniprot
proteins
pubmed
1731338
uniprot
proteins
pubmed
18036228
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
1827122
uniprot
proteins
pubmed
18586676
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2241892
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24328034
uniprot
proteins
pubmed
2521952
uniprot
proteins
pubmed
2530225
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2784859
uniprot
proteins
pubmed
3711098
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, microvillus {ECO:0000250|UniProtKB:P13838}. Cell projection, uropodium {ECO:0000250|UniProtKB:P15702}. Note=Localizes to the uropodium and microvilli via its interaction with ERM proteins (EZR, RDX and MSN). {ECO:0000250|UniProtKB:P13838, ECO:0000250|UniProtKB:P15702}.; SUBCELLULAR LOCATION: [CD43 cytoplasmic tail]: Nucleus {ECO:0000269|PubMed:15003504}. Nucleus, PML body {ECO:0000250|UniProtKB:P15702}. Note=The sumoylated form localizes to the PML body. {ECO:0000250|UniProtKB:P15702}.
uniprot
proteins
transmembrane_region
TRANSMEM 254..276; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins