Ipmk
entrez
171458
canonical
uniprot
Q99NI4
canonical
ensembl
ENSRNOG00000000609
resolver
ensp
ENSRNOP00000000748
resolver
ensp
ENSRNOP00000093022
resolver
enst
ENSRNOT00000000748
resolver
genesymbol
Ipmk
resolver
genesymbol_syn
Impk
resolver
genesymbol_syn
Ipk2
resolver
uniprot
A0A8L2PZ63
resolver
uniprot_entry
A0A8L2PZ63_RAT
resolver
uniprot_entry
IPMK_RAT
resolver
amino_acid_sequence
MAAEPPALRLRPPGSTGDSPPVPRLLGGCVPLSHQVAGHMYGKDKVGILQHPDGTVLKQLQPPPRGPRELEFYTMVYAADCADAVLLELRKHLPKYYGVWSPPSAPNDVYLKLEDVTHKFNKPCIMDVKIGRKSYDPFASAEKIQQQVSKYPLMEEIGFLVLGMRVYHLHSDSYETQNQHYGRGLTKETLKEGVSKFFHNGFCLRKDAVAASIQKVEKILQWFENQKQLNFYASSLLFVYEGSSQPATTKSNDRTLAGRFLSKGALSDADVLECNNNFHLFSSPANGTSVGKSLSKAYSRHRKLYAKKHQSQTSLKVETLEQDNGWKSMSQEHLNGNVLSQLEKVFYHLPAGRQEIAEAEVRMIDFAHVFPSNTVDEGYVYGLKHLIAVLRSILDS
uniprot
proteins
ec_number
2.7.1.140
uniprot
proteins
ec_number
2.7.1.151
uniprot
proteins
ec_number
2.7.1.153
uniprot
proteins
function
FUNCTION: Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:11226235, PubMed:15528195). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:15528195). Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) (PubMed:15528195). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:16123124). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (By similarity). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity). {ECO:0000250|UniProtKB:Q7TT16, ECO:0000250|UniProtKB:Q8NFU5, ECO:0000269|PubMed:11226235, ECO:0000269|PubMed:15528195, ECO:0000269|PubMed:16123124}.
uniprot
proteins
mass_dalton
44410
uniprot
proteins
mutagenesis
MUTAGEN 127; /note="D->A: Shows weak but significant activity toward the substrate 1D-myo-inositol 1,4,5-trisphosphate."; /evidence="ECO:0000269|PubMed:15528195
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylinositol metabolism. {ECO:0000269|PubMed:11226235}.
uniprot
proteins
protein_family
Inositol phosphokinase (IPK) family
uniprot
proteins
pubmed
11226235
uniprot
proteins
pubmed
15528195
uniprot
proteins
pubmed
16123124
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15528195, ECO:0000269|PubMed:16123124}.
uniprot
proteins