Macrod1
entrez
246233
canonical
uniprot
Q8K4G6
canonical
ensembl
ENSRNOG00000021174
resolver
ensp
ENSRNOP00000073401
resolver
ensp
ENSRNOP00000097100
resolver
enst
ENSRNOT00000091465
resolver
enst
ENSRNOT00000106741
resolver
genesymbol
Macrod1
resolver
genesymbol_syn
Lrp16
resolver
uniprot
A0A0G2K5F1
resolver
uniprot
A0A8I6AN55
resolver
uniprot_entry
A0A0G2K5F1_RAT
resolver
uniprot_entry
A0A8I6AN55_RAT
resolver
uniprot_entry
MACD1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Subject to competitive inhibition by the product ADP-ribose. {ECO:0000250|UniProtKB:Q9BQ69}.
uniprot
proteins
amino_acid_sequence
AAGRGAWVRTWAPLAMAAKVDLSTSTDWKEAKSFLKGLSDKQREEHYFCKDFIKLKKIPMWKETAKGLAGKVENPKYKKDKQLNEKISLFRGDITKLEVDAIVNAANNSLLGGGGVDGCIHRAAGSLLTDECRTLQNCETGKAKITCGYRLPAKHVIHTVGPIAVGQPTASQAAELRSCYLSSLDLLLEHRLRSVAFPCISTGVFGYPNEEAAEVVLATLREWLEQHKDKVDRLIICVFLEKDEGIYQERLPHYFPVA
uniprot
proteins
ec_number
3.1.1.106
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
function
FUNCTION: Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. {ECO:0000250|UniProtKB:Q9BQ69}.
uniprot
proteins
mass_dalton
28643
uniprot
proteins
protein_family
MacroD-type family
uniprot
proteins
protein_family
MacroD1/2-like subfamily
uniprot
proteins
sequence_length
258
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BQ69}. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. {ECO:0000250|UniProtKB:Q9BQ69}.
uniprot
proteins