Gpsm2
entrez
76123
canonical
uniprot
Q8VDU0
canonical
ensembl
ENSMUSG00000027883
resolver
ensp
ENSMUSP00000029482
resolver
enst
ENSMUST00000029482
resolver
genesymbol
Gpsm2
resolver
genesymbol_syn
Lgn
resolver
genesymbol_syn
Pins
resolver
uniprot
Q3UPG3
resolver
uniprot
Q8BLX3
resolver
uniprot_entry
GPSM2_MOUSE
resolver
uniprot_entry
Q3UPG3_MOUSE
resolver
uniprot_sec
Q8BLX3
resolver
amino_acid_sequence
MEGNLISMREDHSFHVRYRMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDTGEFPEDVRNALQAAVDLYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELKDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLGLSYSTNNSMMSENIEIDGSLHGAGAKLGRRHSMENLELMKLTPEKVPNWNSEILAKQKPLIAKPSAKLLFVNRLKGKKYKSGSACTKVLQDASNSVDHRAPRSQKKISSDTIGDEGFFDLLRRFQSNRMDDQRCHLQGNCRTTSTAAASATPKLMKAPSVSVVSPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTKGNSPSVLERLMTNDKKEPDEDFFDILVKCQGSRLDDQRCAPPSAATKGPTVPDEDFFSLILRSQAKRMDEQRVLLQRDPNRDSEFGLKELLQNNALLEFKHSGK
uniprot
proteins
function
FUNCTION: Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Plays a role in metaphase spindle orientation (By similarity). Plays an important role in asymmetric cell divisions (PubMed:12571286, PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (PubMed:22952234). {ECO:0000250|UniProtKB:P81274, ECO:0000269|PubMed:12571286, ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22952234}.
uniprot
proteins
mass_dalton
75591
uniprot
proteins
mutagenesis
MUTAGEN 210; /note="N->F: Nearly abolishes interaction with NUMA1."; /evidence="ECO:0000269|PubMed:21816348"; MUTAGEN 228; /note="R->A: Abolishes interaction with NUMA1; when associated with A-243. Abolishes interaction with FRMPD1; when associated with A-243."; /evidence="ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:23318951"; MUTAGEN 243; /note="R->A: Abolishes interaction with NUMA1; when associated with A-228. Abolishes interaction with FRMPD1; when associated with A-228."; /evidence="ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:23318951"; MUTAGEN 254; /note="F->E: Abolishes interaction with INSC."; /evidence="ECO:0000269|PubMed:21816348"; MUTAGEN 290; /note="N->E: Abolishes interaction with INSC."; /evidence="ECO:0000269|PubMed:21816348"; MUTAGEN 601; /note="L->E: Disrupts one GNAI3 binding site."; /evidence="ECO:0000269|PubMed:22952234"; MUTAGEN 635; /note="I->E: Disrupts one GNAI3 binding site."; /evidence="ECO:0000269|PubMed:22952234"; MUTAGEN 642; /note="R->A,G: Reduces affinity for GDP-bound GNAI3 50-fold. Reduces affinity for GDP-bound GNAI3 500-fold; when associated with A-647."; /evidence="ECO:0000269|PubMed:22952234"; MUTAGEN 647; /note="R->A: Reduces affinity for GDP-bound GNAI3 500-fold; when associated with A-642."; /evidence="ECO:0000269|PubMed:22952234
uniprot
proteins
protein_family
GPSM family
uniprot
proteins
pubmed
12571286
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16094321
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21816348
uniprot
proteins
pubmed
22952234
uniprot
proteins
pubmed
23318951
uniprot
proteins
pubmed
23665171
uniprot
proteins
pubmed
26766442
uniprot
proteins
pubmed
31112734
uniprot
proteins
pubmed
34272044
uniprot
proteins
sequence_length
679
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P81274}. Cytoplasm, cell cortex {ECO:0000269|PubMed:26766442}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P81274}. Lateral cell membrane {ECO:0000269|PubMed:26766442}. Note=Localizes in the cytoplasm during interphase and at cell cortex during metaphase. Colocalizes with NUMA1 to mitotic spindle poles. Localized at the central and lateral cell cortex regions in a RanGTP-dependent manner (By similarity). In horizontally retinal progenitor dividing cells, localized to the lateral cortical region (PubMed:26766442). In vertically retinal progenitor dividing cells, localized at the polar cortical region (PubMed:26766442). {ECO:0000250|UniProtKB:P81274, ECO:0000269|PubMed:26766442}.
uniprot
proteins