Cdca5
entrez
67849
canonical
uniprot
Q9CPY3
canonical
ensembl
ENSMUSG00000024791
resolver
ensp
ENSMUSP00000025704
resolver
genesymbol
Cdca5
resolver
uniprot
Q78HI6
resolver
uniprot_entry
CDCA5_MOUSE
resolver
uniprot_sec
Q78HI6
resolver
amino_acid_sequence
MAERRTRSGGAAQRSGPRTSLTKPSKSSKRKSGSDLPNSFSEIWPRTTPAVPVRKAIVLKKIVAHAVEVPDVHTVRRSPRISFILEKENNPPLKVPTKEDLFKTCSVPGTPSSTPVLYTQNVEPDSGEAELDSRDLEMSQKVRRSYSRLQSLGCASTSTPGRRSFFGFEGPDDLPGVSPVVCSKLIETPKVPAKDLVPARTKDLVPDSTKDLVPARTLPGISPPVVKEKRKKKVPEILKSELDKWAVAMNAEFEAAEQFELLIE
uniprot
proteins
function
FUNCTION: Regulator of sister chromatid cohesion in mitosis, stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:21111234}.
uniprot
proteins
mass_dalton
28991
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPL by CDCA5 (By similarity). {ECO:0000250|UniProtKB:Q96FF9}.; PTM: Ubiquitinated by the APC/C complex in G1, leading to its degradation. {ECO:0000250|UniProtKB:Q96FF9}.
uniprot
proteins
protein_family
Sororin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21111234
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
264
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21111234}. Chromosome {ECO:0000269|PubMed:21111234}. Cytoplasm {ECO:0000269|PubMed:21111234}. Note=Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.
uniprot
proteins