CORO1B
entrez
57175
canonical
uniprot
Q9BR76
canonical
ensembl
ENSG00000172725
resolver
ensp
ENSP00000340211
resolver
ensp
ENSP00000377471
resolver
ensp
ENSP00000572824
resolver
ensp
ENSP00000572829
resolver
ensp
ENSP00000588444
resolver
ensp
ENSP00000625964
resolver
ensp
ENSP00000625965
resolver
enst
ENST00000341356
resolver
enst
ENST00000393893
resolver
enst
ENST00000902765
resolver
enst
ENST00000902770
resolver
enst
ENST00000918385
resolver
enst
ENST00000955905
resolver
enst
ENST00000955906
resolver
genesymbol
CORO1B
resolver
hgnc
HGNC:2253
resolver
uniprot
B2RD45
resolver
uniprot_entry
COR1B_HUMAN
resolver
uniprot_sec
B2RD45
resolver
amino_acid_sequence
MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQDDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLSDSRPAMAPGSSHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEEQLGRMENGDA
uniprot
proteins
function
FUNCTION: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). {ECO:0000250, ECO:0000269|PubMed:16027158}.
uniprot
proteins
mass_dalton
54235
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="S->A: Stronger interaction with the Arp2/3 complex. Does not affect homooligomerization. Enhanced ruffling in response to phorbol 12-myristate 13-acetate (PMA) and increased speed in fibroblasts."; /evidence="ECO:0000269|PubMed:16027158"; MUTAGEN 2; /note="S->D: Weaker interaction with the Arp2/3 complex. Does not affect homooligomerization. Attenuated PMA-induced ruffling and slower speed in fibroblasts."; /evidence="ECO:0000269|PubMed:16027158
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PKC on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location. {ECO:0000269|PubMed:16027158}.
uniprot
proteins
protein_family
WD repeat coronin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16027158
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
489
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16027158}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:16027158}. Note=Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers. {ECO:0000269|PubMed:16027158}.
uniprot
proteins