Osbpl6
entrez
99031
canonical
uniprot
Q8BXR9
canonical
ensembl
ENSMUSG00000042359
resolver
ensp
ENSMUSP00000077123
resolver
ensp
ENSMUSP00000107560
resolver
ensp
ENSMUSP00000107561
resolver
ensp
ENSMUSP00000251703
resolver
ensp
ENSMUSP00000251704
resolver
ensp
ENSMUSP00000251705
resolver
ensp
ENSMUSP00000251707
resolver
ensp
ENSMUSP00000251708
resolver
ensp
ENSMUSP00000251711
resolver
ensp
ENSMUSP00000251712
resolver
ensp
ENSMUSP00000251715
resolver
ensp
ENSMUSP00000251718
resolver
ensp
ENSMUSP00000251725
resolver
ensp
ENSMUSP00000251729
resolver
ensp
ENSMUSP00000251745
resolver
ensp
ENSMUSP00000251748
resolver
ensp
ENSMUSP00000251751
resolver
ensp
ENSMUSP00000251753
resolver
ensp
ENSMUSP00000251754
resolver
ensp
ENSMUSP00000251758
resolver
ensp
ENSMUSP00000251760
resolver
enst
ENSMUST00000077972
resolver
genesymbol
Osbpl6
resolver
uniprot
F8WIZ7
resolver
uniprot
Q8BYW2
resolver
uniprot_entry
F8WIZ7_MOUSE
resolver
uniprot_entry
OSBL6_MOUSE
resolver
uniprot_sec
Q8BYW2
resolver
amino_acid_sequence
MSSDEKGISPAHKTSTPTHRSASSSTSSQRESRQSIHVLERTASSSTEPSVSRQLLEPEPIPLSKEADSWEIIEGLKIGQTNVQKPDRHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKSQDWFDAWVSKLRHHRLYRQNEIVRSPRDASFHIFPATSTAESSPAANVSVVDGKMQPNSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQNLEILQRTQSAPNFTDMQANCVDISKKDKRVTRRWRTKSVSKDTKIQLQEGPPAKGQFNTTRRRQRLAAAVATTVPFSATMSPVRLHSSNPNLCADIEFQTPPSHLTDPLESSTDYTKLQEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQVVSEQDHNKGHSTQMARLRQSLSQALNQNAELRSRLNRIHSESTICDHVVSVNIIPSPDEPGEQIHVSLPLSQQVANESRLSMSESVSEFFDAQEVLLSASSSENEASDDESYISDVSDNISEDNTSVADNISRQILNGELTGGAFRNGRRTCLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVTLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTLRNTKSSVCICKLTFVKVNYWNSNVNEVQGVVIDQEGKVVHRLFGKWHEGLYCGVAPSAKCIWRPGSLPTNYELYYGFTRFAVELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAAAEKQRVEELQRSRRRYMEENNLEHIPKFFKKVIDANQREAWVSNDTYWELRKDPGFSKVDSPVLW
uniprot
proteins
function
FUNCTION: Regulates cellular transport and efflux of cholesterol. Plays a role in phosphatidylinositol-4-phosphate (PI4P) turnover at the neuronal membrane (PubMed:30028970, PubMed:35518199). Localizes at the neurons plasma membrane-endoplasmic reticulum contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) from the endoplasmic reticulum for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) from the plasma membrane (PubMed:35518199). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (PubMed:30028970). Weakly binds 25-hydroxycholesterol (By similarity). {ECO:0000250|UniProtKB:Q9BZF3, ECO:0000269|PubMed:30028970, ECO:0000269|PubMed:35518199}.
uniprot
proteins
mass_dalton
108920
uniprot
proteins
protein_family
OSBP family
uniprot
proteins
pubmed
14593528
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26941018
uniprot
proteins
pubmed
30028970
uniprot
proteins
pubmed
35518199
uniprot
proteins
sequence_length
959
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:14593528}. Cytoplasm, cytosol {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:30028970}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:30028970, ECO:0000269|PubMed:35518199}; Peripheral membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:35518199}; Peripheral membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:30028970}; Peripheral membrane protein {ECO:0000305}. Note=Co-localizes with OSBPL3 at contact sites between the plasma membrane and the endoplasmic reticulum. {ECO:0000269|PubMed:30028970, ECO:0000269|PubMed:35518199}.
uniprot
proteins