HPGDS
entrez
27306
canonical
uniprot
O60760
canonical
ensembl
ENSG00000163106
resolver
ensp
ENSP00000295256
resolver
ensp
ENSP00000614291
resolver
enst
ENST00000295256
resolver
genesymbol
HPGDS
resolver
genesymbol_syn
GSTS
resolver
genesymbol_syn
PGDS
resolver
genesymbol_syn
PTGDS2
resolver
hgnc
HGNC:17890
resolver
uniprot
A0A384P5J0
resolver
uniprot
Q6FHT9
resolver
uniprot_entry
A0A384P5J0_HUMAN
resolver
uniprot_entry
HPGDS_HUMAN
resolver
uniprot_sec
Q6FHT9
resolver
activity_regulation
ACTIVITY REGULATION: Prostaglandin PGD2 synthesis is stimulated by calcium and magnesium ions. One calcium or magnesium ion is bound between the subunits of the homodimer. The interactions with the protein are for the most part mediated via water molecules. Magnesium increases the affinity for glutathione, while calcium has no effect on the affinity for glutathione. {ECO:0000269|PubMed:12627223}.
uniprot
proteins
amino_acid_sequence
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
uniprot
proteins
ec_number
2.5.1.18
uniprot
proteins
ec_number
5.3.99.2
uniprot
proteins
function
FUNCTION: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates (PubMed:10824118, PubMed:11672424, PubMed:12244105, PubMed:12627223, PubMed:15113825, PubMed:16547010, PubMed:17519235, PubMed:19939518, PubMed:9353279, PubMed:9425264). Similarly, catalyzes the conversion of PGH3 (derived from eicosapentaenoate (EPA, C20:5n-3)) to PGD3, though PGH2 remains the preferred substrate (PubMed:17519235). Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. {ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12244105, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:17519235, ECO:0000269|PubMed:19939518, ECO:0000269|PubMed:9353279, ECO:0000269|PubMed:9425264}.
uniprot
proteins
mass_dalton
23344
uniprot
proteins
mutagenesis
MUTAGEN 93; /note="D->N: Loss of activation by calcium or magnesium ions."; /evidence="ECO:0000269|PubMed:12627223"; MUTAGEN 96; /note="D->N: Increases PGD2 synthesis. Loss of activation by calcium or magnesium ions."; /evidence="ECO:0000269|PubMed:12627223"; MUTAGEN 97; /note="D->N: Reduces PGD2 synthesis by 99%. Loss of activation by calcium or magnesium ions."; /evidence="ECO:0000269|PubMed:12627223
uniprot
proteins
protein_family
GST superfamily
uniprot
proteins
protein_family
Sigma family
uniprot
proteins
pubmed
10824118
uniprot
proteins
pubmed
11672424
uniprot
proteins
pubmed
12244105
uniprot
proteins
pubmed
12627223
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15113825
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16547010
uniprot
proteins
pubmed
17519235
uniprot
proteins
pubmed
18341273
uniprot
proteins
pubmed
19939518
uniprot
proteins
pubmed
9353279
uniprot
proteins
pubmed
9425264
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9353279}.
uniprot
proteins