Dis3l2
entrez
208718
canonical
uniprot
Q8CI75
canonical
ensembl
ENSMUSG00000053333
resolver
ensp
ENSMUSP00000070506
resolver
ensp
ENSMUSP00000132673
resolver
ensp
ENSMUSP00000262075
resolver
ensp
ENSMUSP00000262078
resolver
ensp
ENSMUSP00000262080
resolver
ensp
ENSMUSP00000262084
resolver
genesymbol
Dis3l2
resolver
uniprot
Q8BMG9
resolver
uniprot_entry
DI3L2_MOUSE
resolver
uniprot_sec
Q8BMG9
resolver
amino_acid_sequence
MNHPDYKLNLRSPGTPRGVSSVVGPSAVGASPGDKKSKNKSMRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEDQWKAVKPESNDKEIEATYEADIPEEGCGHHPLQQSRKGWSGPDVIIEAQFDDSDSEDRHGNTSGLVDGVKKLSISTPDRGKEDSSTPVMKDENTPIPQDTRGLSEKSLQKSAKVVYILEKKHSRAATGILKLLADKNSDLFKKYALFSPSDHRVPRIYVPLKDCPQDFMTRPKDFANTLFICRIIDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQSLPWTIPPDEVGKRRDLRKDCIFTIDPSTARDLDDALACRRLTDGTFEVGVHIADVSYFVPEGSSLDKVAAERATSVYLVQKVVPMLPRLLCEELCSLNPMTDKLTFSVIWKLTPEGKILEEWFGRTIIRSCTKLSYDHAQSMIENPTEKIPEEELPPISPEHSVEEVHQAVLNLHSIAKQLRRQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRDSNKLVEEFMLLANMAVAHKIFRTFPEQALLRRHPPPQTKMLSDLVEFCDQMGLPMDVSSAGALNKSLTKTFGDDKYSLARKEVLTNMYSRPMQMALYFCSGMLQDQEQFRHYALNVPLYTHFTSPIRRFADVIVHRLLAAALGYSEQPDVEPDTLQKQADHCNDRRMASKRVQELSIGLFFAVLVKESGPLESEAMVMGVLNQAFDVLVLRFGVQKRIYCNALALRSYSFQKVGKKPELTLVWEPDDLEEEPTQQVITIFSLVDVVLQAEATALKYSAILKRPGLEKASDEEPED
uniprot
proteins
ec_number
3.1.13.-
uniprot
proteins
function
FUNCTION: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23594738, ECO:0000269|PubMed:25119025}.
uniprot
proteins
mass_dalton
97775
uniprot
proteins
mutagenesis
MUTAGEN 74; /note="R->A: Loss of enzyme activity and polyuridylated RNA-binding; when associated with A-612."; /evidence="ECO:0000269|PubMed:25119025"; MUTAGEN 389; /note="D->N: Loss of exoribonuclease activity."; /evidence="ECO:0000269|PubMed:23594738"; MUTAGEN 548..553; /note="RLDQLK->AAAAAA: 40% decreased enzyme activity."; /evidence="ECO:0000269|PubMed:25119025"; MUTAGEN 612; /note="Q->A: Loss of enzyme activity and polyuridylated RNA-binding; when associated with A-74."; /evidence="ECO:0000269|PubMed:25119025"; MUTAGEN 777; /note="N->A: 40% increased enzyme activity."; /evidence="ECO:0000269|PubMed:25119025"; MUTAGEN 778; /note="Q->A: Impaired enzyme activity and polyuridylated RNA-binding."; /evidence="ECO:0000269|PubMed:25119025"; MUTAGEN 796; /note="N->A: Does not affect enzyme activity."; /evidence="ECO:0000269|PubMed:25119025
uniprot
proteins
protein_family
DIS3L2 subfamily
uniprot
proteins
protein_family
RNR ribonuclease family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23594738
uniprot
proteins
pubmed
25119025
uniprot
proteins
sequence_length
870
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23594738}. Cytoplasm, P-body {ECO:0000255|HAMAP-Rule:MF_03045}.
uniprot
proteins