Pkp1
entrez
18772
canonical
uniprot
P97350
canonical
ensembl
ENSMUSG00000026413
resolver
ensp
ENSMUSP00000027667
resolver
ensp
ENSMUSP00000128418
resolver
enst
ENSMUST00000027667
resolver
enst
ENSMUST00000163260
resolver
genesymbol
Pkp1
resolver
uniprot
B2RSX3
resolver
uniprot_entry
PKP1_MOUSE
resolver
uniprot_sec
B2RSX3
resolver
amino_acid_sequence
MNHSPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQVMMTVKRQKSKSSQSSTLSHSNRGSMYDGLADNYNNYGTTSRSSYFSKFQAGNGSWGYPIYNGTLKREPDNRRFSSYSQMENWSRHYPRGSCATPGAGSDICFMQKIKASRSEPDLYCDPRGTLRKGTLGSKGHKTTQNRCSFYSTCSGQKAVKKCPVRPPSCTSKQDPVYVPPISCNKDLSFGHSRASSKICSEDIECSGLTIPKAVQYLCSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTPNKLETRRQNGIREAVSLLRRSGSTEIQKQLTGLLWNLSSTDELKEELVADALPVLTDRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCILHNLSYRLDAEVPTRYRQLEYNTRNAYTEKSSTGCFSNRGDKMMNNNYDCPLPEEETNPKGSSWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSNGMSQLIGIKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPVLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTVRNLMTSQPQMAKQYFSNSMLNNVFNLCRNTASSPKAAEAARLLLSDMWASKELQSVLRQQGFDRNMMGNIAGANNLRNFTSRF
uniprot
proteins
function
FUNCTION: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:27033150, PubMed:29678907). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:27033150, PubMed:29678907). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (By similarity). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (PubMed:28507225). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (PubMed:27375112). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (PubMed:30949721). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:27033150). Required for tight junction inside-out transepidermal barrier function of the skin, and is thereby involved in neonatal survival possibly via maintenance of hydration levels (PubMed:27033150). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (PubMed:27015268). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (By similarity). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (By similarity). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:27375112). {ECO:0000250|UniProtKB:Q13835, ECO:0000269|PubMed:27015268, ECO:0000269|PubMed:27033150, ECO:0000269|PubMed:27375112, ECO:0000269|PubMed:28507225, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:30949721}.
uniprot
proteins
mass_dalton
80896
uniprot
proteins
mutagenesis
MUTAGEN 4; /note="S->A: Abolishes phosphorylation by RIPK4."; /evidence="ECO:0000269|PubMed:28507225"; MUTAGEN 120; /note="S->A: Abolishes phosphorylation by RIPK4."; /evidence="ECO:0000269|PubMed:28507225"; MUTAGEN 143; /note="S->A: Abolishes phosphorylation by RIPK4."; /evidence="ECO:0000269|PubMed:28507225
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by AKT2; required for interaction with YWHAG and subsequent localization away from desmosomes to the cytoplasm (PubMed:29678907). Phosphorylation of Ser-119 by AKT2 promotes PKP1-driven cap-dependent mRNA translation and decreases intercellular adhesion, phosphorylation is promoted by insulin (By similarity). Phosphorylation by RIPK4 at the N-terminus is required for its role in differentiation of keratinocytes and DSG1 localization at cell junctions (PubMed:28507225). {ECO:0000250|UniProtKB:Q13835, ECO:0000269|PubMed:28507225, ECO:0000269|PubMed:29678907}.
uniprot
proteins
protein_family
Beta-catenin family
uniprot
proteins
pubmed
10852826
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18079750
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27015268
uniprot
proteins
pubmed
27033150
uniprot
proteins
pubmed
27375112
uniprot
proteins
pubmed
28507225
uniprot
proteins
pubmed
29678907
uniprot
proteins
pubmed
30949721
uniprot
proteins
sequence_length
728
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27015268, ECO:0000269|PubMed:27375112}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q13835}. Cytoplasm {ECO:0000269|PubMed:27015268, ECO:0000269|PubMed:27033150, ECO:0000269|PubMed:27375112, ECO:0000269|PubMed:29678907}. Cell junction, desmosome {ECO:0000269|PubMed:27033150, ECO:0000269|PubMed:27375112, ECO:0000269|PubMed:29678907}. Cell membrane {ECO:0000269|PubMed:27015268}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q13835}. Note=Colocalizes with EIF4A1 in stress granules following arsenate or hydrogen peroxide treatment (By similarity). Localizes to nucleoli following DNA damage (By similarity). Located in the cytoplasm during early tooth development, however localizes to the cell membrane in ameloblasts during molar growth (PubMed:27015268). Ca(2+)-mediated localization to the cell membrane in dental epithelial cells is inhibited via WNT3A (PubMed:27015268). Initially localized to the cytoplasm however as keratinocyte differentiation proceeds becomes localized to cell junctions as early cell-cell contacts become linear as part of membrane sealing (PubMed:27375112). Localized to lateral cell contacts in colocalization with DSP as epithelial sheet formation completes (PubMed:27375112). Localizes to the cytoplasm when the phosphorylated form interacts with YWHAG (PubMed:29678907). Protein stability is increased and localizes to the cytoplasm when phosphorylated at the N-terminus by AKT2 (By similarity). The unphosphorylated form is preferentially localized to desmosomes (By similarity). {ECO:0000250|UniProtKB:Q13835, ECO:0000269|PubMed:27015268, ECO:0000269|PubMed:27375112, ECO:0000269|PubMed:29678907}.
uniprot
proteins