Paox
entrez
212503
canonical
uniprot
Q8C0L6
canonical
ensembl
ENSMUSG00000025464
resolver
ensp
ENSMUSP00000026537
resolver
ensp
ENSMUSP00000095580
resolver
ensp
ENSMUSP00000218275
resolver
ensp
ENSMUSP00000218283
resolver
enst
ENSMUST00000097967
resolver
genesymbol
Paox
resolver
genesymbol_syn
Pao
resolver
uniprot
F6XAE7
resolver
uniprot
Q3TXR6
resolver
uniprot
Q8K254
resolver
uniprot_entry
F6XAE7_MOUSE
resolver
uniprot_entry
PAOX_MOUSE
resolver
uniprot_entry
Q3TXR6_MOUSE
resolver
uniprot_sec
Q8K254
resolver
amino_acid_sequence
MAFPGPRVLVVGSGIAGLGAAQKLCSHRAAPHLRVLEATASAGGRIRSERCFGGVVELGAHWIHGPSQDNPVFQLAAEFGLLGEKELSEENQLVDTGGHVALPSMIWSSSGTSVSLELMTEMARLFYGLIERTREFLNESETPMASVGEFLKKEISQQVASWTEDDEDTRKRKLAILNTFFNIECCVSGTHSMDLVALAPFGEYTVLPGLDCILAGGYQGLTDRILASLPKDTVAFDKPVKTIHWNGSFQEAAFPGETFPVLVECEDGARLPAHHVIVTVPLGFLKEHQDTFFEPPLPAKKAEAIKKLGFGTNNKIFLEFEEPFWEPDCQFIQVVWEDTSPLQDTALSLQDTWFKKLIGFLVQPSFESSHVLCGFIAGLESEFMETLSDEEVLLSLTQVLRRVTGNPQLPAAKSVRRSQWHSAPYTRGSYSYVAVGSTGDDLDLMAQPLPEDGTGTQLQVLFAGEATHRTFYSTTHGALLSGWREADRLVSLWDSQVEQSRPRL
uniprot
proteins
ec_number
1.5.3.13
uniprot
proteins
function
FUNCTION: Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12660232, PubMed:28029774). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12660232). {ECO:0000269|PubMed:12660232, ECO:0000269|PubMed:28029774}.
uniprot
proteins
mass_dalton
55447
uniprot
proteins
mutagenesis
MUTAGEN 313; /note="N->A,D,L,T: Decreased enzyme activity with N(1)-acetylspermine."; /evidence="ECO:0000269|PubMed:28029774
uniprot
proteins
pathway_participation
PATHWAY: Amine and polyamine metabolism; spermine metabolism. {ECO:0000269|PubMed:12660232, ECO:0000269|PubMed:28029774}.
uniprot
proteins
protein_family
Flavin monoamine oxidase family
uniprot
proteins
pubmed
12660232
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28029774
uniprot
proteins
sequence_length
504
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}. Cytoplasm {ECO:0000250}.
uniprot
proteins