PEDS1
entrez
387521
canonical
uniprot
A5PLL7
canonical
ensembl
ENSG00000240849
resolver
ensp
ENSP00000360713
resolver
ensp
ENSP00000360715
resolver
genesymbol
PEDS1
resolver
genesymbol_syn
KUA
resolver
genesymbol_syn
PEDS
resolver
genesymbol_syn
TMEM189
resolver
hgnc
HGNC:16735
resolver
uniprot_entry
PEDS1_HUMAN
resolver
amino_acid_sequence
MAGAENWPGQQLELDEDEASCCRWGAQHAGARELAALYSPGKRLQEWCSVILCFSLIAHNLVHLLLLARWEDTPLVILGVVAGALIADFLSGLVHWGADTWGSVELPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTHSPEALEQLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHHVSPHETYFCITTGWLNYPLEKIGFWRRLEDLIQGLTGEKPRADDMKWAQKIK
uniprot
proteins
ec_number
1.14.19.77
uniprot
proteins
function
FUNCTION: Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane (PubMed:31604315, PubMed:32209662, PubMed:33859415). Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms (PubMed:31604315). {ECO:0000269|PubMed:31604315, ECO:0000269|PubMed:32209662, ECO:0000269|PubMed:33859415, ECO:0000303|PubMed:31604315}.
uniprot
proteins
mass_dalton
31135
uniprot
proteins
mutagenesis
MUTAGEN 95; /note="H->A: Loss of plasmanylethanolamine desaturase activity."; /evidence="ECO:0000269|PubMed:31604315"; MUTAGEN 120; /note="H->A: Loss of plasmanylethanolamine desaturase activity."; /evidence="ECO:0000269|PubMed:31604315"; MUTAGEN 121; /note="H->A: Loss of plasmanylethanolamine desaturase activity."; /evidence="ECO:0000269|PubMed:31604315"; MUTAGEN 130; /note="H->A: Loss of plasmanylethanolamine desaturase activity."; /evidence="ECO:0000269|PubMed:31604315"; MUTAGEN 186; /note="H->A: Loss of plasmanylethanolamine desaturase activity."; /evidence="ECO:0000269|PubMed:31604315"; MUTAGEN 190; /note="H->A: Loss of plasmanylethanolamine desaturase activity."; /evidence="ECO:0000269|PubMed:31604315"; MUTAGEN 206; /note="H->A: No effect on plasmanylethanolamine desaturase activity."; /evidence="ECO:0000269|PubMed:31604315"; MUTAGEN 213; /note="H->A: No effect on plasmanylethanolamine desaturase activity."; /evidence="ECO:0000269|PubMed:31604315"; MUTAGEN 214; /note="H->A: Loss of plasmanylethanolamine desaturase activity."; /evidence="ECO:0000269|PubMed:31604315"; MUTAGEN 217; /note="H->A: Loss of plasmanylethanolamine desaturase activity."; /evidence="ECO:0000269|PubMed:31604315"; MUTAGEN 218; /note="H->A: Loss of plasmanylethanolamine desaturase activity."; /evidence="ECO:0000269|PubMed:31604315"; MUTAGEN 222; /note="H->A: No effect on desaturase plasmanylethanolamine activity."; /evidence="ECO:0000269|PubMed:31604315
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000269|PubMed:31604315}.
uniprot
proteins
protein_family
Fatty acid desaturase CarF family
uniprot
proteins
pubmed
11076860
uniprot
proteins
pubmed
11280764
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
31604315
uniprot
proteins
pubmed
32209662
uniprot
proteins
pubmed
33859415
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11076860, ECO:0000269|PubMed:31604315}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 74..94; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins