PLXNB1
entrez
5364
canonical
uniprot
O43157
canonical
ensembl
ENSG00000164050
resolver
ensp
ENSP00000296440
resolver
ensp
ENSP00000351338
resolver
ensp
ENSP00000529483
resolver
ensp
ENSP00000529484
resolver
ensp
ENSP00000529486
resolver
ensp
ENSP00000604760
resolver
ensp
ENSP00000604766
resolver
ensp
ENSP00000618951
resolver
genesymbol
PLXNB1
resolver
genesymbol_syn
KIAA0407
resolver
genesymbol_syn
PLXN5
resolver
genesymbol_syn
SEP
resolver
hgnc
HGNC:9103
resolver
uniprot
A6H8Y2
resolver
uniprot
Q6NY20
resolver
uniprot
Q9UIV7
resolver
uniprot
Q9UJ92
resolver
uniprot
Q9UJ93
resolver
uniprot_entry
PLXB1_HUMAN
resolver
uniprot_sec
A6H8Y2
resolver
uniprot_sec
Q6NY20
resolver
uniprot_sec
Q9UIV7
resolver
uniprot_sec
Q9UJ92
resolver
uniprot_sec
Q9UJ93
resolver
amino_acid_sequence
MPALGPALLQALWAGWVLTLQPLPPTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSPGALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGVGGGIPPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEGGRYGLIQAAAVATSREVAHGEVLFAAFSSAAPPTVGRPPSAAAGASGASALCAFPLDEVDRLANRTRDACYTREGRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGPEQWLWSFQPELGCLQVAAMSPANISREETREVFLSVPDLPPLWPGESYSCHFGEHQSPALLTGSGVMCPSPDPSEAPVLPRGADYVSVSVELRFGAVVIAKTSLSFYDCVAVTELRPSAQCQACVSSRWGCNWCVWQHLCTHKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPATVPATTFPGAMGSVKPALDWLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQYDTPGLWELEEATLGASSCPCVESVQGSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLEVVVEARVECEPPPDTQCHVTCQQHQLSYEALQPELRVGLFLRRAGRLRVDSAEGLHVVLYDCSVGHGDCSRCQTAMPQYGCVWCEGERPRCVTREACGEAEAVATQCPAPLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVAGATAVEVPGRGRGVSEHDFAYQDPKVHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQPCHLLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRLQRGQFKYTLDPNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRVTVVSRMLQPSQGLGRRRRVVPETACSLGPSCSSQQFEEPCHVNSSQLITCRTPALPGLPEDPWVRVEFILDNLVFDFATLNPTPFSYEADPTLQPLNPEDPTMPFRHKPGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPPVEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGLGVGTSLLALGVIIIVLMYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCLTKHVLRENQDYVPGERTPMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGYRLQQIAAAVENKVTDL
uniprot
proteins
function
FUNCTION: Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496). {ECO:0000250|UniProtKB:Q8CJH3, ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496, ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}.
uniprot
proteins
mass_dalton
232298
uniprot
proteins
mutagenesis
MUTAGEN 139; /note="D->K: Strongly reduced interaction with SEMA4D."; /evidence="ECO:0000269|PubMed:20877282"; MUTAGEN 1302..1305; /note="RRRR->AAAA: Abolishes cleavage by proprotein convertases."; /evidence="ECO:0000269|PubMed:12533544"; MUTAGEN 1815; /note="L->F,P: Abolishes interaction with RAC1 and RND1."; /evidence="ECO:0000269|PubMed:18275816"; MUTAGEN 1884..1885; /note="WH->SS: Loss of cytoskeleton remodeling in response to SEMA4D."; /evidence="ECO:0000269|PubMed:19843518
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding. {ECO:0000269|PubMed:10520995, ECO:0000269|PubMed:15210733}.; PTM: Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding. {ECO:0000269|PubMed:12533544}.
uniprot
proteins
protein_family
Plexin family
uniprot
proteins
pubmed
10520995
uniprot
proteins
pubmed
11035813
uniprot
proteins
pubmed
12196628
uniprot
proteins
pubmed
12198496
uniprot
proteins
pubmed
12533544
uniprot
proteins
pubmed
12730235
uniprot
proteins
pubmed
15184888
uniprot
proteins
pubmed
15210733
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17916560
uniprot
proteins
pubmed
18275816
uniprot
proteins
pubmed
18411422
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19843518
uniprot
proteins
pubmed
20877282
uniprot
proteins
pubmed
21912513
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8570614
uniprot
proteins
pubmed
9455477
uniprot
proteins
sequence_length
2135
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12533544}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:10520995}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:10520995}.
uniprot
proteins
transmembrane_region
TRANSMEM 1491..1511; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins