SMG5
entrez
23381
canonical
uniprot
Q9UPR3
canonical
ensembl
ENSG00000198952
resolver
ensp
ENSP00000355261
resolver
ensp
ENSP00000528659
resolver
ensp
ENSP00000528661
resolver
enst
ENST00000361813
resolver
genesymbol
SMG5
resolver
genesymbol_syn
EST1B
resolver
genesymbol_syn
KIAA1089
resolver
hgnc
HGNC:24644
resolver
uniprot
D3DVB7
resolver
uniprot
Q5QJE7
resolver
uniprot
Q659C7
resolver
uniprot
Q8IXC0
resolver
uniprot
Q8IY09
resolver
uniprot
Q96IJ7
resolver
uniprot_entry
SMG5_HUMAN
resolver
uniprot_sec
D3DVB7
resolver
uniprot_sec
Q5QJE7
resolver
uniprot_sec
Q659C7
resolver
uniprot_sec
Q8IXC0
resolver
uniprot_sec
Q8IY09
resolver
uniprot_sec
Q96IJ7
resolver
amino_acid_sequence
MSQGPPTGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLRELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGDLSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVIICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELPDLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHPGARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQGAGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG
uniprot
proteins
function
FUNCTION: Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. {ECO:0000269|PubMed:17053788}.
uniprot
proteins
mass_dalton
113928
uniprot
proteins
mutagenesis
MUTAGEN 860; /note="D->A: Abolishes stimulation of RENT1 dephosphorylation."; /evidence="ECO:0000269|PubMed:14636577
uniprot
proteins
pubmed
10470851
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12699629
uniprot
proteins
pubmed
14636577
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15546618
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17053788
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
1016
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14636577}. Nucleus {ECO:0000269|PubMed:14636577}. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies.
uniprot
proteins