RPS10
entrez
6204
canonical
uniprot
P46783
canonical
ensembl
ENSG00000124614
resolver
ensp
ENSP00000481646
resolver
ensp
ENSP00000494190
resolver
ensp
ENSP00000494440
resolver
ensp
ENSP00000497917
resolver
ensp
ENSP00000550063
resolver
ensp
ENSP00000589515
resolver
ensp
ENSP00000589517
resolver
ensp
ENSP00000589518
resolver
ensp
ENSP00000589519
resolver
ensp
ENSP00000589527
resolver
ensp
ENSP00000589528
resolver
ensp
ENSP00000589529
resolver
ensp
ENSP00000589530
resolver
ensp
ENSP00000589531
resolver
enst
ENST00000464218
resolver
enst
ENST00000467531
resolver
enst
ENST00000621356
resolver
enst
ENST00000648437
resolver
enst
ENST00000880004
resolver
enst
ENST00000919456
resolver
enst
ENST00000919458
resolver
enst
ENST00000919459
resolver
enst
ENST00000919460
resolver
enst
ENST00000919468
resolver
enst
ENST00000919469
resolver
enst
ENST00000919470
resolver
enst
ENST00000919471
resolver
enst
ENST00000919472
resolver
genesymbol
RPS10
resolver
hgnc
HGNC:10383
resolver
uniprot
B2R4E3
resolver
uniprot
Q5TZC0
resolver
uniprot_entry
RS10_HUMAN
resolver
uniprot_sec
B2R4E3
resolver
uniprot_sec
Q5TZC0
resolver
amino_acid_sequence
MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARLTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ
uniprot
proteins
disease_involvement
DISEASE: Diamond-Blackfan anemia 9 (DBA9) [MIM:613308]: An autosomal dominant form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269|PubMed:20116044}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Component of the 40S ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). {ECO:0000269|PubMed:23636399}.
uniprot
proteins
mass_dalton
18898
uniprot
proteins
mutagenesis
MUTAGEN 138..139; /note="KK->RR: Abolishes monoubiquitination by ZNF598, leading to enhanced readthrough on the poly(A)-stall sequences."; /evidence="ECO:0000269|PubMed:28065601, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:28685749, ECO:0000269|PubMed:32011234, ECO:0000269|PubMed:36302773"; MUTAGEN 158; /note="R->K: Weakly methylated. Complete loss of methylation; inefficient assembly into ribosomes; instability; increased degradation by the proteasomal pathway; decreased interaction with NPM1; absence of localization in the granular component (GC) region of the nucleolus; when associated with K-160."; /evidence="ECO:0000269|PubMed:20159986"; MUTAGEN 160; /note="R->K: Weakly methylated. Complete loss of methylation; inefficient assembly into ribosomes; instability; increased degradation by the proteasomal pathway; decreased interaction with NPM1; absence of localization in the granular component (GC) region of the nucleolus; when associated with K-158."; /evidence="ECO:0000269|PubMed:20159986
uniprot
proteins
post_translational_modification
PTM: Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation. {ECO:0000269|PubMed:20159986}.; PTM: Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:32011234, PubMed:36302773). Deubiquitinated by OTUD3 and USP21, antagonizing ZNF598 activity (PubMed:32011234). Deubiquitinated by OTUD1, antagonizing ZNF598 activity and stimulating formation of polysomes: deubiquitination by OTUD1 promotes stability and translation of a subset mRNAs with a high abundance of rare codons can limit the translation rate (PubMed:36445135). Deubiquitinated by USP10 (PubMed:31981475). {ECO:0000269|PubMed:28065601, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:28685749, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32011234, ECO:0000269|PubMed:36302773, ECO:0000269|PubMed:36445135}.
uniprot
proteins
protein_family
Eukaryotic ribosomal protein eS10 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20116044
uniprot
proteins
pubmed
20159986
uniprot
proteins
pubmed
23636399
uniprot
proteins
pubmed
24524803
uniprot
proteins
pubmed
28065601
uniprot
proteins
pubmed
28132843
uniprot
proteins
pubmed
28685749
uniprot
proteins
pubmed
31981475
uniprot
proteins
pubmed
32011234
uniprot
proteins
pubmed
36302773
uniprot
proteins
pubmed
36445135
uniprot
proteins
pubmed
7772601
uniprot
proteins
pubmed
8706699
uniprot
proteins
pubmed
9582194
uniprot
proteins
sequence_length
165
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20159986, ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:20159986}. Note=Localized in the granular component (GC) region of the nucleolus. Methylation is required for its localization in the GC region. Colocalizes with NPS1 in the GC region of the nucleolus. {ECO:0000269|PubMed:20159986}.
uniprot
proteins