GABRE
entrez
2564
canonical
uniprot
P78334
canonical
ensembl
ENSG00000102287
resolver
ensp
ENSP00000359353
resolver
genesymbol
GABRE
resolver
hgnc
HGNC:4085
resolver
uniprot
E7ET93
resolver
uniprot
O15345
resolver
uniprot
O15346
resolver
uniprot
Q6PCD2
resolver
uniprot
Q99520
resolver
uniprot_entry
GBRE_HUMAN
resolver
uniprot_sec
E7ET93
resolver
uniprot_sec
O15345
resolver
uniprot_sec
O15346
resolver
uniprot_sec
Q6PCD2
resolver
uniprot_sec
Q99520
resolver
activity_regulation
ACTIVITY REGULATION: Potentiated by pentobarbital, loreclezole, and lanthanum and inhibited by zinc and furosemide (PubMed:9882711). Introduction of the epsilon subunit to the receptor complex resulted in diminished modulatory effects by etomidate, propofol, pregnanolone and flurazepam (PubMed:16412217). {ECO:0000269|PubMed:16412217, ECO:0000269|PubMed:9882711}.
uniprot
proteins
amino_acid_sequence
MLSKVLPVLLGILLILQSRVEGPQTESKNEASSRDVVYGPQPQPLENQLLSEETKSTETETGSRVGKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEERPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRLDNYSRVVFPVTFFFFNVLYWLVCLNL
uniprot
proteins
function
FUNCTION: Epsilon subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:16412217, PubMed:9882711). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABAARs containing epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (PubMed:16412217, PubMed:9882711). GABARs containing epsilon subunit may regulate cardiac function (Probable). {ECO:0000250|UniProtKB:P08219, ECO:0000250|UniProtKB:P47870, ECO:0000269|PubMed:16412217, ECO:0000269|PubMed:9882711, ECO:0000305|PubMed:9084408}.
uniprot
proteins
mass_dalton
57972
uniprot
proteins
protein_family
GABRE sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16412217
uniprot
proteins
pubmed
9039914
uniprot
proteins
pubmed
9084408
uniprot
proteins
pubmed
9339354
uniprot
proteins
pubmed
9882711
uniprot
proteins
sequence_length
506
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 281..301; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 308..327; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 486..506; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins