Sema3e
entrez
20349
canonical
uniprot
P70275
canonical
ensembl
ENSMUSG00000063531
resolver
ensp
ENSMUSP00000073612
resolver
enst
ENSMUST00000073957
resolver
genesymbol
Sema3e
resolver
genesymbol_syn
Semah
resolver
genesymbol_syn
Semh
resolver
uniprot
O09078
resolver
uniprot
O09079
resolver
uniprot
Q9QX23
resolver
uniprot_entry
SEM3E_MOUSE
resolver
uniprot_sec
O09078
resolver
uniprot_sec
O09079
resolver
uniprot_sec
Q9QX23
resolver
amino_acid_sequence
MAPAGHILTLLLWGHLLELWTPGHSANPSYPRLRLSHKELLELNRTSIFQSPLGFLDLHTMLLDEYQERLFVGGRDLVYSLNLERVSDGYREIYWPSTAVKVEECIMKGKDANECANYIRVLHHYNRTHLLTCATGAFDPHCAFIRVGHHSEEPLFHLESHRSERGRGRCPFDPNSSFVSTLVGNELFAGLYSDYWGRDSAIFRSMGKLGHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKMYFFFTEKALEAENNAHTIYTRVGRLCVNDMGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTRDPKNPVIFGLFNTTSNIFRGHAVCVYHMSSIREAFNGPYAHKEGPEYHWSLYEGKVPYPRPGSCASKVNGGKYGTTKDYPDDAIRFARMHPLMYQPIKPVHKKPILVKTDGKYNLRQLAVDRVEAEDGQYDVLFIGTDTGIVLKVITIYNQETEWMEEVILEELQIFKDPAPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGISCSRYYPTGAHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDRTEERLAYGIESNSTLLECTPRSLQAKVIWFVQKGRDVRKEEVKTDDRVVKMDLGLLFLRVRKSDAGTYFCQTVEHNFVHTVRKITLEVVEEHKVEGMFHKDHEEERHHKMPCPPLSGMSQGTKPWYKEFLQLIGYSNFQRVEEYCEKVWCTDKKRKKLKMSPSKWKYANPQEKRLRSKAEHFRLPRHTLLS
uniprot
proteins
function
FUNCTION: Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation. {ECO:0000269|PubMed:15550623, ECO:0000269|PubMed:19421194, ECO:0000269|PubMed:20385769, ECO:0000269|PubMed:22179111}.
uniprot
proteins
mass_dalton
89543
uniprot
proteins
protein_family
Semaphorin family
uniprot
proteins
pubmed
10430503
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15550623
uniprot
proteins
pubmed
19421194
uniprot
proteins
pubmed
20385769
uniprot
proteins
pubmed
22179111
uniprot
proteins
pubmed
9515811
uniprot
proteins
sequence_length
775
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins