Mpst
entrez
246221
canonical
uniprot
Q99J99
canonical
ensembl
ENSMUSG00000071711
resolver
ensp
ENSMUSP00000043061
resolver
ensp
ENSMUSP00000128075
resolver
ensp
ENSMUSP00000130493
resolver
ensp
ENSMUSP00000155371
resolver
ensp
ENSMUSP00000317932
resolver
ensp
ENSMUSP00000340530
resolver
ensp
ENSMUSP00000352482
resolver
enst
ENSMUST00000043865
resolver
enst
ENSMUST00000167140
resolver
enst
ENSMUST00000169133
resolver
enst
ENSMUST00000229739
resolver
genesymbol
Mpst
resolver
uniprot
Q3UW66
resolver
uniprot
Q505N7
resolver
uniprot_entry
THTM_MOUSE
resolver
uniprot_sec
Q3UW66
resolver
uniprot_sec
Q505N7
resolver
activity_regulation
ACTIVITY REGULATION: By oxidative stress, and thioredoxin. Under oxidative stress conditions, the catalytic cysteine site is converted to a sulfenate which inhibits the MPST enzyme activity. Reduced thioredoxin cleaves an intersubunit disulfide bond to turn on the redox switch and reactivate the enzyme. Inhibited by different oxidants, hydrogen peroxide and tetrathionate. {ECO:0000250|UniProtKB:P97532}.
uniprot
proteins
amino_acid_sequence
MAAPQLFRALVSAQWVAEALKAPRSSQPLKLLDASWYLPKLGRDARREFEERHIPGAAFFDIDRCSDHTSPYDHMLPNATHFADYAGSLGVSAATHVVIYDDSDQGLYSAPRVWWMFRAFGHHSVSLLDGGFRHWLNQNLPISSGKSHSEPAEFSAQLDPSFIKTHEDILENLDARRFQVVDARAAGRFQGTQPEPRDGIEPGHIPGSVNIPFTEFLTNEGLEKSPEEIKRLFKEKKVDLSKPLVATCGSGVTACHVVLGAFLCGKSDVPVYDGSWVEWYMRAQPEHIISEGRGKTQ
uniprot
proteins
ec_number
2.8.1.2
uniprot
proteins
function
FUNCTION: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions. {ECO:0000269|PubMed:18855522, ECO:0000269|PubMed:21937432, ECO:0000269|PubMed:22808324, ECO:0000269|PubMed:28079151}.
uniprot
proteins
mass_dalton
33097
uniprot
proteins
mutagenesis
MUTAGEN 188; /note="R->G: Abolishes hydrogen sulfide production. Slightly increased basal levels of bound persulfide."; /evidence="ECO:0000269|PubMed:18855522"; MUTAGEN 197; /note="R->G: Reduces hydrogen sulfide production by 50%. No change in basal levels of bound persulfide."; /evidence="ECO:0000269|PubMed:18855522"; MUTAGEN 248; /note="C->S: Loss of redox potential. Abolishes bound persulfide and hydrogen sulfide production."; /evidence="ECO:0000269|PubMed:18855522
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18855522
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21732914
uniprot
proteins
pubmed
21937432
uniprot
proteins
pubmed
22808324
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
28079151
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P97532}. Mitochondrion {ECO:0000269|PubMed:18855522}. Synapse, synaptosome {ECO:0000269|PubMed:18855522}.
uniprot
proteins