MSL1
entrez
339287
canonical
uniprot
Q68DK7
canonical
ensembl
ENSG00000188895
resolver
ensp
ENSP00000381543
resolver
ensp
ENSP00000462731
resolver
ensp
ENSP00000462945
resolver
ensp
ENSP00000463949
resolver
enst
ENST00000577454
resolver
enst
ENST00000578648
resolver
genesymbol
MSL1
resolver
genesymbol_syn
MSL1L1
resolver
hgnc
HGNC:27905
resolver
uniprot
B3KWR7
resolver
uniprot
J3KSZ8
resolver
uniprot
J3QQY0
resolver
uniprot
Q0VF46
resolver
uniprot
Q69Z03
resolver
uniprot_entry
B3KWR7_HUMAN
resolver
uniprot_entry
J3KSZ8_HUMAN
resolver
uniprot_entry
J3QQY0_HUMAN
resolver
uniprot_entry
MSL1_HUMAN
resolver
uniprot_sec
Q0VF46
resolver
uniprot_sec
Q69Z03
resolver
amino_acid_sequence
MTMRSAVFKAAAAPAGGNPEQRLDYERAAALGGPEDEPGAAEAHFLPRHRKLKEPGPPLASSQGGSPAPSPAGCGGKGRGLLLPAGAAPGQQEESWGGSVPLPCPPPATKQAGIGGEPAAAGAGCSPRPKYQAVLPIQTGSLVAAAKEPTPWAGDKGGAASPAATASDPAGPPPLPLPGPPPLAPTATAGTLAASEGRWKSMRKSPLGGGGGSGASSQAACLKQILLLQLDLIEQQQQQLQAKEKEIEELKSERDTLLARIERMERRMQLVKKDNEKERHKLFQGYETEEREETELSEKIKLECQPELSETSQTLPPKPFSCGRSGKGHKRKSPFGSTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSLSETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEIEDLPYLSTTEMYLCRWHQPPPSPLPLRESSPKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPLRDPNPSDLLENLDDSVFSKRHAKLELDEKRRKRWDIQRIREQRILQRLQLRMYKKKGIQESEPEVTSFFPEPDDVESLMITPFLPVVAFGRPLPKLTPQNFELPWLDERSRCRLEIQKKQTPHRTCRK
uniprot
proteins
function
FUNCTION: Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}.
uniprot
proteins
mass_dalton
67128
uniprot
proteins
post_translational_modification
PTM: Sumoylated with SUMO1. {ECO:0000269|PubMed:15561718}.
uniprot
proteins
protein_family
Msl-1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15561718
uniprot
proteins
pubmed
16227571
uniprot
proteins
pubmed
16543150
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19650074
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21217699
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21726816
uniprot
proteins
pubmed
22547026
uniprot
proteins
pubmed
23084835
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
30224647
uniprot
proteins
pubmed
30930284
uniprot
proteins
pubmed
33837287
uniprot
proteins
sequence_length
614
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15561718}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q6PDM1}. Nucleus speckle {ECO:0000250|UniProtKB:Q6PDM1}.
uniprot
proteins