Nupr1
entrez
100912108
canonical
uniprot
O54842
canonical
ensembl
ENSRNOG00000019206
resolver
ensp
ENSRNOP00000107734
resolver
enst
ENSRNOT00000025988
resolver
genesymbol
Nupr1
resolver
uniprot_entry
NUPR1_RAT
resolver
amino_acid_sequence
MATLPPTAHTSQQPVNIEDEDGILDEYDQYSLAQSYVVGGGRKGRTKREAAANTNRPSPGGHERKLLTKFQNSERKKAWR
uniprot
proteins
function
FUNCTION: Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:20181828, PubMed:27031958, PubMed:28694771). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (By similarity). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (By similarity). Negatively regulates apoptosis through interaction with PTMA (By similarity). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (PubMed:27031958, PubMed:28694771). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4 'Lys-16' acetylation (H4K16ac) (By similarity). Coactivator of PAX2 transcription factor activity, both by recruiting the EP300 cofactor to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (By similarity). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (By similarity). Coordinates, through its interaction with EP300, the association of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (By similarity). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity). {ECO:0000250|UniProtKB:O60356, ECO:0000250|UniProtKB:Q9WTK0, ECO:0000269|PubMed:20181828, ECO:0000269|PubMed:27031958, ECO:0000269|PubMed:28694771}.
uniprot
proteins
mass_dalton
8955
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation promotes DNA-binding activity. {ECO:0000250|UniProtKB:O60356}.; PTM: Acetylated. {ECO:0000250|UniProtKB:O60356}.
uniprot
proteins
protein_family
NUPR family
uniprot
proteins
pubmed
20181828
uniprot
proteins
pubmed
27031958
uniprot
proteins
pubmed
27451286
uniprot
proteins
pubmed
28694771
uniprot
proteins
pubmed
9405444
uniprot
proteins
sequence_length
80
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O60356}. Cytoplasm {ECO:0000250|UniProtKB:O60356}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O60356}.
uniprot
proteins