Il20
entrez
58181
canonical
uniprot
Q9JKV9
canonical
ensembl
ENSMUSG00000026416
resolver
ensp
ENSMUSP00000027673
resolver
ensp
ENSMUSP00000141088
resolver
enst
ENSMUST00000027673
resolver
enst
ENSMUST00000188581
resolver
genesymbol
Il20
resolver
genesymbol_syn
Zcyto10
resolver
uniprot
A0A087WSK8
resolver
uniprot
Q2NKI0
resolver
uniprot
Q2THG5
resolver
uniprot_entry
A0A087WSK8_MOUSE
resolver
uniprot_entry
IL20_MOUSE
resolver
uniprot_entry
Q2NKI0_MOUSE
resolver
uniprot_entry
Q2THG5_MOUSE
resolver
amino_acid_sequence
MKGFGLAFGLFSAVGFLLWTPLTGLKTLHLGSCVITANLQAIQKEFSEIRDSVQAEDTNIDIRILRTTESLKDIKSLDRCCFLRHLVRFYLDRVFKVYQTPDHHTLRKISSLANSFLIIKKDLSVCHSHMACHCGEEAMEKYNQILSHFIELELQAAVVKALGELGILLRWMEEML
uniprot
proteins
function
FUNCTION: Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation (PubMed:23793061). Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity. Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration. Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB. Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB (By similarity). Acts as an arteriogenic and vascular remodeling factory by activating a range of signaling processes including phosphorylations of JAK2 and STAT5 as well as activation of the serine and threonine kinases AKT and ERK1/2 (PubMed:17878297). Alternatively, can activate STAT3 phosphorylation and transcriptional activity in a JAK2, ERK1/2 and p38 MAPK-dependent manner in keratinocytes (By similarity). {ECO:0000250|UniProtKB:Q9NYY1, ECO:0000269|PubMed:17878297, ECO:0000269|PubMed:23793061}.
uniprot
proteins
mass_dalton
20098
uniprot
proteins
protein_family
IL-10 family
uniprot
proteins
pubmed
11163236
uniprot
proteins
pubmed
17878297
uniprot
proteins
pubmed
23793061
uniprot
proteins
sequence_length
176
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins