Stambp
entrez
171565
canonical
uniprot
Q8R424
canonical
ensembl
ENSRNOG00000012227
resolver
ensembl
ENSRNOG00055012819
resolver
ensembl
ENSRNOG00060003051
resolver
ensembl
ENSRNOG00065016083
resolver
ensp
ENSRNOP00000014708
resolver
ensp
ENSRNOP00055017750
resolver
ensp
ENSRNOP00060003674
resolver
ensp
ENSRNOP00065020983
resolver
enst
ENSRNOT00000014708
resolver
enst
ENSRNOT00055021908
resolver
enst
ENSRNOT00060005019
resolver
enst
ENSRNOT00065026736
resolver
genesymbol
Stambp
resolver
genesymbol_syn
Amsh
resolver
uniprot_entry
STABP_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethylmaleimide. {ECO:0000250|UniProtKB:O95630}.
uniprot
proteins
amino_acid_sequence
MSDHADVSLPPQDRVRILSQLGSAVELNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAFILYNKYITLFIEKLPKHRDYKSAIIPEKKDAVKKLKNVAFPKAEELKTELLKRYTKEYEQYKERKKKEEEELARNIAIQQELEKEKQRVAQQKQKQLEQEQFHAFEKMIQKQELEKERLKIVQEFGKVDPGPCGPLLPDLEKPCVDVAPSSPFSPTQTSDCNTTLRPAKPPVVDRSLKPGALSVIENVPTIEGLRHIVVPRNLCSEFLQLASANTAKGIETCGVLCGKLMRNEFTITHVLIPRQNGGPDYCHTENEEEIFFMQDDLGLLTLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKFQETGFFKLTDYGLQEISTCRQKGFHPHGRDPPLFCDCSHVTVKDRIVTITDLR
uniprot
proteins
ec_number
3.4.19.-
uniprot
proteins
function
FUNCTION: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. {ECO:0000250|UniProtKB:O95630}.
uniprot
proteins
mass_dalton
48512
uniprot
proteins
post_translational_modification
PTM: Phosphorylated after BMP type I receptor activation. {ECO:0000250|UniProtKB:O95630}.; PTM: Ubiquitinated by SMURF2 in the presence of RNF11. {ECO:0000250|UniProtKB:O95630}.
uniprot
proteins
protein_family
Peptidase M67C family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95630}. Membrane {ECO:0000250|UniProtKB:O95630}; Peripheral membrane protein {ECO:0000250|UniProtKB:O95630}. Cytoplasm {ECO:0000250|UniProtKB:O95630}. Early endosome {ECO:0000250|UniProtKB:O95630}.
uniprot
proteins