Tmem87a
entrez
211499
canonical
uniprot
Q8BXN9
canonical
ensembl
ENSMUSG00000033808
resolver
ensp
ENSMUSP00000087496
resolver
ensp
ENSMUSP00000087500
resolver
ensp
ENSMUSP00000106357
resolver
ensp
ENSMUSP00000194939
resolver
ensp
ENSMUSP00000194943
resolver
ensp
ENSMUSP00000194945
resolver
enst
ENSMUST00000090042
resolver
enst
ENSMUST00000090046
resolver
genesymbol
Tmem87a
resolver
genesymbol_syn
Golphcat
resolver
uniprot
A2AQJ5
resolver
uniprot
A2AQJ6
resolver
uniprot
Q8BTV9
resolver
uniprot
Q8BU98
resolver
uniprot
Q8R2P9
resolver
uniprot
Q8R3S7
resolver
uniprot_entry
A2AQJ5_MOUSE
resolver
uniprot_entry
A2AQJ6_MOUSE
resolver
uniprot_entry
GPHCC_MOUSE
resolver
uniprot_sec
Q8BTV9
resolver
uniprot_sec
Q8BU98
resolver
uniprot_sec
Q8R2P9
resolver
uniprot_sec
Q8R3S7
resolver
amino_acid_sequence
MAVAAWLQVSPVIFLLLGAQPFPLSFLGAGPAPVFAADRSKWHIPMPSGKGYFNFGKILFRNTTILLKFDGEPCDQSLNITWFLKSADCYNEIYNFKADEIESYLENLKGKKGLSGRYQTSSRLFQNCSELYKAQSFSGDFTHRLPLLGEKQEAKENATNVTFTGDKIAMHEPLQTWQDAPYIFIVHVGISSSKESPKENALSNLFTMTVEVKGPYEYLTLEDYPLMIFFMVMCIVYVLFGVLWLAWSACYWRDLLRIQFWIGAVIFLGMFEKAVFYAEFQNIRYKGESVQNALVLAELLSAVKRSLARTLVIIVSLGYGIVKPRLGVTLHKVVVAGALYLLFSGMEGVLRVTGAQTDLASLAFIPLAFLDTALCWWIFISLTQTMKLLKLRRNIVKLSLYRHFTNTLILAVAASIVFIIWTTMKFRIVTCQSDWRELWVDDAIWRLLFSMILFVIMILWRPSANNQRFAFSPLSEEDEEDEQKEPMLKESFEGMKMRSTKQEPNGTSKVNKAQEDDLKWVEENVPSSVTDVALPALLDSDEERMITHFERSKME
uniprot
proteins
function
FUNCTION: Voltage- and pH-dependent, inwardly rectifying cation channel that mediates ion flux across the Golgi membrane, supporting luminal acidification necessary for normal Golgi morphology and function (PubMed:38992057). Implicated in normal touch sensitivity through the generation of mechanically activated currents (PubMed:38422143). Could also be involved in cell mechanosensitivity regulating cell adhesion and migration (PubMed:32228863). May also be involved in retrograde transport from endosomes to the trans-Golgi network (TGN) (By similarity). Contributes to hippocampal spatial and contextual memory by maintaining Golgi function and structural integrity in hippocampal neurons (PubMed:38992057). {ECO:0000250|UniProtKB:Q8NBN3, ECO:0000269|PubMed:32228863, ECO:0000269|PubMed:38422143, ECO:0000269|PubMed:38992057}.
uniprot
proteins
mass_dalton
63380
uniprot
proteins
mutagenesis
MUTAGEN 271; /note="F->L: Increased mechanosensitive channel activity in Tmem87a-expressing cells; when associated with G-292."; /evidence="ECO:0000269|PubMed:32228863"; MUTAGEN 292; /note="N->G: Increased mechanosensitive channel activity in Tmem87a-expressing cells; when associated with L-271."; /evidence="ECO:0000269|PubMed:32228863
uniprot
proteins
protein_family
LU7TM family
uniprot
proteins
protein_family
TMEM87 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32228863
uniprot
proteins
pubmed
38422143
uniprot
proteins
pubmed
38992057
uniprot
proteins
sequence_length
555
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:Q8NBN3}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:38992057}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000250|UniProtKB:Q8NBN3}; Multi-pass membrane protein {ECO:0000255}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q8NBN3}.
uniprot
proteins
transmembrane_region
TRANSMEM 226..246; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 306..322; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 326..346; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 404..424; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 438..458; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins