Tifa
entrez
310877
canonical
uniprot
Q5XIB9
canonical
ensembl
ENSRNOG00000010941
resolver
ensembl
ENSRNOG00055026603
resolver
ensembl
ENSRNOG00060003272
resolver
ensembl
ENSRNOG00065015295
resolver
ensp
ENSRNOP00000061870
resolver
ensp
ENSRNOP00000077082
resolver
ensp
ENSRNOP00000087830
resolver
ensp
ENSRNOP00000088802
resolver
ensp
ENSRNOP00000101228
resolver
ensp
ENSRNOP00000105247
resolver
ensp
ENSRNOP00000107732
resolver
ensp
ENSRNOP00000111274
resolver
ensp
ENSRNOP00000111754
resolver
ensp
ENSRNOP00055037647
resolver
ensp
ENSRNOP00055037657
resolver
ensp
ENSRNOP00055037659
resolver
ensp
ENSRNOP00060003951
resolver
ensp
ENSRNOP00060003956
resolver
ensp
ENSRNOP00060003958
resolver
ensp
ENSRNOP00065019892
resolver
ensp
ENSRNOP00065019902
resolver
ensp
ENSRNOP00065019904
resolver
enst
ENSRNOT00000014533
resolver
enst
ENSRNOT00000097096
resolver
enst
ENSRNOT00000102851
resolver
enst
ENSRNOT00000112612
resolver
enst
ENSRNOT00000151461
resolver
enst
ENSRNOT00000151568
resolver
enst
ENSRNOT00000159449
resolver
enst
ENSRNOT00000173023
resolver
enst
ENSRNOT00000173754
resolver
enst
ENSRNOT00055045916
resolver
enst
ENSRNOT00055045926
resolver
enst
ENSRNOT00055045928
resolver
enst
ENSRNOT00060005371
resolver
enst
ENSRNOT00060005378
resolver
enst
ENSRNOT00060005380
resolver
enst
ENSRNOT00065025367
resolver
enst
ENSRNOT00065025377
resolver
enst
ENSRNOT00065025379
resolver
genesymbol
Tifa
resolver
uniprot_entry
TIFA_RAT
resolver
amino_acid_sequence
MSTFEDADTEETVTCLQMTIYHPGQLQSGIFKSIRFCSKEKFPSIEVVKFGRNSNMCQYTFQDKQVSRVQFALQPFKQFNSSVLSFEIKNMSKKTSLMVDNQELGYLNKMDLPYKCMLRFGEYQFLLQKEDGESVESFETQFILSPRPLLQENNWPTQSPIPEDGVYSSYFTHRSSPAEMDENEL
uniprot
proteins
function
FUNCTION: Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of pro-inflammatory NF-kappa-B signaling. {ECO:0000250|UniProtKB:Q96CG3}.
uniprot
proteins
mass_dalton
21548
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-9 following detection of ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose) by ALPK1. Phosphorylation at Thr-9 by ALPK1 leads to the formation of an intermolecular binding between the FHA domain and phosphorylated Thr-9, promoting TIFA oligomerization and TIFA-mediated NF-kappa-B activation. {ECO:0000250|UniProtKB:Q96CG3}.
uniprot
proteins
protein_family
TIFA family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
185
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96CG3}. Note=Colocalizes with lysosomal marker LAMP2 following homooligomerization and subsequent activation. {ECO:0000250|UniProtKB:Q96CG3}.
uniprot
proteins