Ifng
entrez
25712
canonical
uniprot
P01581
canonical
ensembl
ENSRNOG00000007468
resolver
ensembl
ENSRNOG00055012332
resolver
ensembl
ENSRNOG00060008537
resolver
ensembl
ENSRNOG00065013127
resolver
ensp
ENSRNOP00000009917
resolver
ensp
ENSRNOP00055016967
resolver
ensp
ENSRNOP00060010936
resolver
ensp
ENSRNOP00065016670
resolver
enst
ENSRNOT00000009919
resolver
enst
ENSRNOT00055020995
resolver
enst
ENSRNOT00060014240
resolver
enst
ENSRNOT00065021518
resolver
genesymbol
Ifng
resolver
uniprot_entry
IFNG_RAT
resolver
amino_acid_sequence
MSATRRVLVLQLCLMALSGCYCQGTLIESLESLKNYFNSSSMDAMEGKSLLLDIWRNWQKDGNTKILESQIISFYLRLFEVLKDNQAISNNISVIESHLITNFFSNSKAKKDAFMSIAKFEVNNPQIQHKAVNELIRVIHQLSPESSLRKRKRSRC
uniprot
proteins
function
FUNCTION: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity). {ECO:0000250|UniProtKB:P01579, ECO:0000250|UniProtKB:P01580}.
uniprot
proteins
mass_dalton
17918
uniprot
proteins
protein_family
Type II (or gamma) interferon family
uniprot
proteins
pubmed
3093809
uniprot
proteins
pubmed
3924594
uniprot
proteins
sequence_length
156
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01579}.
uniprot
proteins