Tor1a
entrez
266606
canonical
uniprot
Q68G38
canonical
ensembl
ENSRNOG00000006894
resolver
ensembl
ENSRNOG00065000366
resolver
ensembl
ENSRNOG00065021114
resolver
ensp
ENSRNOP00000063691
resolver
ensp
ENSRNOP00065000485
resolver
ensp
ENSRNOP00065028945
resolver
enst
ENSRNOT00065000551
resolver
enst
ENSRNOT00065035897
resolver
genesymbol
Tor1a
resolver
genesymbol_syn
Dyt1
resolver
uniprot
Q8K3L8
resolver
uniprot_entry
TOR1A_RAT
resolver
uniprot_sec
Q8K3L8
resolver
amino_acid_sequence
MKLGRATLALLLLVPCVVRAVEPISLGLALAGVLTGYISYPRLYCLFAECCGQKRSLSREALQKDLDNKLFGQHLAKRVILNAVSGFLSNPKPKKPLTLSLHGWTGTGKNFASKIIAENIYEGGLNSDYVHLFVATLHFPHASNITLYKDQLQMWIRGNVSACARSIFIFDEMDKMHAGLIDAIKPFLDYYDVVDEVSYQKAIFIFLSNAGAERITDVALDFWRSGKQREEIKLRDMEHALAVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEEDEDIINKVAEEMTFFPKEEKVFSDKGCKTVFTKLDYYLDD
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues (By similarity). {ECO:0000250|UniProtKB:O14656}.
uniprot
proteins
mass_dalton
37949
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:12671990, ECO:0000269|PubMed:14970196}.
uniprot
proteins
protein_family
ClpA/ClpB family
uniprot
proteins
protein_family
Torsin subfamily
uniprot
proteins
pubmed
12007841
uniprot
proteins
pubmed
12671990
uniprot
proteins
pubmed
14970196
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18167355
uniprot
proteins
pubmed
21102408
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:O14656}. Nucleus inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, growth cone. Cytoplasmic vesicle membrane. Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Peripherally associated with the inner face of the ER membrane, probably mediated by the interaction with TOR1AIP1. The association with nucleus envelope is mediated by the interaction with TOR1AIP2. Upon oxidative stress, redistributes to protusions from the cell surface.
uniprot
proteins