Akr1d1
entrez
208665
canonical
uniprot
Q8VCX1
canonical
ensembl
ENSMUSG00000038641
resolver
ensp
ENSMUSP00000048830
resolver
ensp
ENSMUSP00000222607
resolver
ensp
ENSMUSP00000222608
resolver
ensp
ENSMUSP00000222621
resolver
ensp
ENSMUSP00000222623
resolver
enst
ENSMUST00000040987
resolver
genesymbol
Akr1d1
resolver
uniprot_entry
AK1D1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Subject to inhibition by high substrate concentrations. Inhibited by testosterone concentrations above 10 uM. Inhibited by the primary and secondary bile acids chenodeoxycholic acid and ursodeoxycholic acid. {ECO:0000250|UniProtKB:P51857}.
uniprot
proteins
amino_acid_sequence
MNLSAAHHQISLSDGNNIPLIGLGTYSDPRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEIYPRDENGRIIYDKTNLCATWEALEACKDAGLVKSLGVSNFNRRQLELILNKPGLKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRNPSWVNVSSPPLLNDELLTSLGKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRYVELLMWSDHPEYPFHDEY
uniprot
proteins
ec_number
1.3.1.3
uniprot
proteins
function
FUNCTION: Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one). {ECO:0000250|UniProtKB:P51857}.
uniprot
proteins
mass_dalton
37290
uniprot
proteins
protein_family
Aldo/keto reductase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P51857}.
uniprot
proteins