FCRL1
entrez
115350
canonical
uniprot
Q96LA6
canonical
ensembl
ENSG00000163534
resolver
ensp
ENSP00000351039
resolver
ensp
ENSP00000357158
resolver
ensp
ENSP00000418130
resolver
ensp
ENSP00000533075
resolver
ensp
ENSP00000533077
resolver
genesymbol
FCRL1
resolver
genesymbol_syn
FCRH1
resolver
genesymbol_syn
IFGP1
resolver
genesymbol_syn
IRTA5
resolver
hgnc
HGNC:18509
resolver
uniprot
B2RE05
resolver
uniprot
Q8N759
resolver
uniprot
Q8NDI0
resolver
uniprot
Q96PJ6
resolver
uniprot_entry
FCRL1_HUMAN
resolver
uniprot_sec
B2RE05
resolver
uniprot_sec
Q8N759
resolver
uniprot_sec
Q8NDI0
resolver
uniprot_sec
Q96PJ6
resolver
amino_acid_sequence
MLPRLLLLICAPLCEPAELFLIASPSHPTEGSPVTLTCKMPFLQSSDAQFQFCFFRDTRALGPGWSSSPKLQIAAMWKEDTGSYWCEAQTMASKVLRSRRSQINVHRVPVADVSLETQPPGGQVMEGDRLVLICSVAMGTGDITFLWYKGAVGLNLQSKTQRSLTAEYEIPSVRESDAEQYYCVAENGYGPSPSGLVSITVRIPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPILYWFYHEDITLGSRSAPSGGGASFNLSLTEEHSGNYSCEANNGLGAQRSEAVTLNFTVPTGARSNHLTSGVIEGLLSTLGPATVALLFCYGLKRKIGRRSARDPLRSLPSPLPQEFTYLNSPTPGQLQPIYENVNVVSGDEVYSLAYYNQPEQESVAAETLGTHMEDKVSLDIYSRLRKANITDVDYEDAM
uniprot
proteins
function
FUNCTION: Type I transmembrane surface glycoprotein preferentially expressed by B-cells that regulates BCR-mediated signaling responses (PubMed:15479727). Recruits ABL1 as the intracellular effector molecule to enhance B-cell activation (By similarity). Also plays a negative role by suppressing ERK activation under homeostatic and BCR-stimulated conditions in a GRB2-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q8R4Y0, ECO:0000269|PubMed:15479727}.
uniprot
proteins
mass_dalton
46936
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines upon activation. {ECO:0000269|PubMed:15479727}.
uniprot
proteins
pubmed
11493702
uniprot
proteins
pubmed
11929751
uniprot
proteins
pubmed
12037601
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15479727
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16849395
uniprot
proteins
pubmed
17974005
uniprot
proteins
sequence_length
429
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15479727, ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:15479727, ECO:0000269|PubMed:16849395}.
uniprot
proteins
transmembrane_region
TRANSMEM 308..328; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins