CCT8
entrez
10694
canonical
uniprot
P50990
canonical
ensembl
ENSG00000156261
resolver
ensembl
ENSG00000291533
resolver
ensp
ENSP00000286788
resolver
ensp
ENSP00000442730
resolver
ensp
ENSP00000486921
resolver
ensp
ENSP00000522685
resolver
enst
ENST00000540844
resolver
genesymbol
CCT8
resolver
genesymbol_syn
C21orf112
resolver
genesymbol_syn
CCTQ
resolver
genesymbol_syn
KIAA0002
resolver
hgnc
HGNC:1623
resolver
uniprot
A6NN54
resolver
uniprot
B4DEM7
resolver
uniprot
B4DQH4
resolver
uniprot
Q4VBP8
resolver
uniprot
Q7Z759
resolver
uniprot_entry
Q7Z759_HUMAN
resolver
uniprot_entry
TCPQ_HUMAN
resolver
uniprot_sec
A6NN54
resolver
uniprot_sec
B4DEM7
resolver
uniprot_sec
B4DQH4
resolver
uniprot_sec
Q4VBP8
resolver
amino_acid_sequence
MALHVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEVFLAKLIAQACVSIFPDSGHFNVDNIRVCKILGSGISSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKDWDDDQND
uniprot
proteins
disease_involvement
DISEASE: Note=De novo genetic variants in nearly every subunit of the TRiC complex, including CCT8, have been found in individuals with a broad spectrum of brain malformations, and clinical phenotypes ranging from mild to severe epilepsy, developmental delay, intellectual disability, ataxia, and other features of cerebral malfunction. {ECO:0000269|PubMed:39480921}.
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
function
FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
uniprot
proteins
mass_dalton
59621
uniprot
proteins
protein_family
TCP-1 chaperonin family
uniprot
proteins
pubmed
10508479
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
14532270
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20080638
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25467444
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
35449234
uniprot
proteins
pubmed
36493755
uniprot
proteins
pubmed
37193829
uniprot
proteins
pubmed
39480921
uniprot
proteins
pubmed
7584026
uniprot
proteins
pubmed
7890169
uniprot
proteins
pubmed
8590283
uniprot
proteins
sequence_length
548
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20080638}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20080638}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:P42932}.
uniprot
proteins