GRK3
entrez
157
canonical
uniprot
P35626
canonical
ensembl
ENSG00000100077
resolver
ensp
ENSP00000317578
resolver
ensp
ENSP00000539618
resolver
ensp
ENSP00000696844
resolver
enst
ENST00000324198
resolver
enst
ENST00000869559
resolver
genesymbol
GRK3
resolver
genesymbol_syn
ADRBK2
resolver
genesymbol_syn
BARK2
resolver
hgnc
HGNC:290
resolver
uniprot
Q8N433
resolver
uniprot
Q9UGW9
resolver
uniprot_entry
GRK3_HUMAN
resolver
uniprot_entry
Q8N433_HUMAN
resolver
uniprot_sec
Q9UGW9
resolver
amino_acid_sequence
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKPRSGTVELPKPSLCHRNSNGL
uniprot
proteins
ec_number
2.7.11.15
uniprot
proteins
ec_number
2.7.11.16
uniprot
proteins
function
FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:21799898, PubMed:33859231). Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:21799898, PubMed:33859231). Phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors (By similarity). Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (PubMed:21799898). Positively regulates ciliary smoothened (SMO) signaling pathway by mediating phosphorylation of SMO, facilitating SMO trafficking into the cilium and the stimulation of SMO activity (By similarity). {ECO:0000250|UniProtKB:P26819, ECO:0000250|UniProtKB:Q3UYH7, ECO:0000269|PubMed:21799898, ECO:0000269|PubMed:33859231}.
uniprot
proteins
mass_dalton
79710
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. {ECO:0000269|PubMed:20596523}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
GPRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
20596523
uniprot
proteins
pubmed
21799898
uniprot
proteins
pubmed
33859231
uniprot
proteins
pubmed
8427589
uniprot
proteins
sequence_length
688
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynapse {ECO:0000250|UniProtKB:P26819}. Presynapse {ECO:0000250|UniProtKB:P26819}.
uniprot
proteins