Nop58
entrez
55989
canonical
uniprot
Q6DFW4
canonical
ensembl
ENSMUSG00000026020
resolver
ensp
ENSMUSP00000140250
resolver
ensp
ENSMUSP00000176941
resolver
ensp
ENSMUSP00000176942
resolver
ensp
ENSMUSP00000176943
resolver
enst
ENSMUST00000191142
resolver
genesymbol
Nop58
resolver
genesymbol_syn
Nol5
resolver
uniprot
O70396
resolver
uniprot
Q3UYX9
resolver
uniprot
Q3UZA3
resolver
uniprot
Q8C8Y7
resolver
uniprot_entry
NOP58_MOUSE
resolver
uniprot_sec
O70396
resolver
uniprot_sec
Q3UYX9
resolver
uniprot_sec
Q3UZA3
resolver
uniprot_sec
Q8C8Y7
resolver
amino_acid_sequence
MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAFTALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIRSQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASASLSEFLSEEVEAEVKAAAEISMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIAHAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQSSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGIENRAKLEARLRILEDRGIRKISGTGKALAKAEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEEVDKEDEITEKKAKKAKIKIKAEVEEEMEEEEAEEEQVVEEEPTVKKKKKKDKKKHIKEEPLSEEEPCTSTAVPSPEKKKKKKKKKDAED
uniprot
proteins
function
FUNCTION: Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs). {ECO:0000250|UniProtKB:Q9Y2X3}.
uniprot
proteins
mass_dalton
60343
uniprot
proteins
post_translational_modification
PTM: Sumoylation is essential for high-affinity binding to snoRNAs. {ECO:0000250|UniProtKB:Q9Y2X3}.
uniprot
proteins
protein_family
NOP5/NOP56 family
uniprot
proteins
pubmed
10864044
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
536
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9Y2X3}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9Y2X3}. Note=Localizes to the nucleolus with a minor part present in the nucleoplasm. {ECO:0000250|UniProtKB:Q9Y2X3}.
uniprot
proteins