Phb2
entrez
114766
canonical
uniprot
Q5XIH7
canonical
ensembl
ENSRNOG00000012999
resolver
ensembl
ENSRNOG00055010230
resolver
ensembl
ENSRNOG00060032455
resolver
ensembl
ENSRNOG00065028930
resolver
ensp
ENSRNOP00000093330
resolver
ensp
ENSRNOP00055013896
resolver
ensp
ENSRNOP00060046418
resolver
ensp
ENSRNOP00065041046
resolver
enst
ENSRNOT00000104665
resolver
enst
ENSRNOT00055017283
resolver
enst
ENSRNOT00060056212
resolver
enst
ENSRNOT00065049967
resolver
genesymbol
Phb2
resolver
genesymbol_syn
Bcap37
resolver
uniprot
P70629
resolver
uniprot
P70630
resolver
uniprot_entry
PHB2_RAT
resolver
uniprot_sec
P70629
resolver
uniprot_sec
P70630
resolver
amino_acid_sequence
MAQNLKDLAGRLPSGPRGMGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTADNLVLNLQDESFTRGSDSLIKGKK
uniprot
proteins
function
FUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. {ECO:0000250|UniProtKB:O35129}.; FUNCTION: In the mitochondria, together with PHB1, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner. Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6. {ECO:0000250|UniProtKB:O35129}.; FUNCTION: In the nucleus, serves as transcriptional co-regulator. Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. {ECO:0000250|UniProtKB:O35129}.; FUNCTION: In the plasma membrane, is involved in IGFBP6-induced cell migration (By similarity). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000250|UniProtKB:Q99623}.
uniprot
proteins
mass_dalton
33312
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Tyrosine phosphorylation is indirectly stimulated by IGFBP6. {ECO:0000250|UniProtKB:Q99623}.
uniprot
proteins
protein_family
Prohibitin family
uniprot
proteins
pubmed
10559001
uniprot
proteins
pubmed
11302691
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11302691}. Cytoplasm {ECO:0000269|PubMed:11302691}. Nucleus {ECO:0000269|PubMed:11302691}. Cell membrane {ECO:0000250|UniProtKB:Q99623}.
uniprot
proteins