Nrros
entrez
224109
canonical
uniprot
Q8BMT4
canonical
ensembl
ENSMUSG00000052384
resolver
ensp
ENSMUSP00000097571
resolver
ensp
ENSMUSP00000110819
resolver
ensp
ENSMUSP00000119349
resolver
ensp
ENSMUSP00000255424
resolver
ensp
ENSMUSP00000255432
resolver
ensp
ENSMUSP00000255433
resolver
genesymbol
Nrros
resolver
genesymbol_syn
Lrrc33
resolver
uniprot
Q3TIA8
resolver
uniprot
Q8BTT4
resolver
uniprot
Q8BUI7
resolver
uniprot
Q8BY16
resolver
uniprot
Q8R063
resolver
uniprot_entry
LRC33_MOUSE
resolver
uniprot_sec
Q3TIA8
resolver
uniprot_sec
Q8BTT4
resolver
uniprot_sec
Q8BUI7
resolver
uniprot_sec
Q8BY16
resolver
uniprot_sec
Q8R063
resolver
amino_acid_sequence
MEFPPLWLCLGFHFLIVEWRSGPGTATAASQGGCKVVDGVADCRGLNLASVPSSLPPHSRMLILDANPLKDLWNHSLQAYPRLENLSLHSCHLDRISHYAFREQGHLRNLVLADNRLSENYKESAAALHTLLGLRRLDLSGNSLTEDMAALMLQNLSSLEVVSLARNTLMRLDDSIFEGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNLPCIVDFSLTQLRFLNVSYNILEWFLAAREEVAFELEILDLSHNQLLFFPLLPQCGKLHTLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFRHLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQISLCPQMVPVDWEGPPSCVDFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNWGVLNGSISPLWAVAPTLQVLSLRDVGLGSGAAEMDFSAFGNLRALDLSGNSLTSFPKFKGSLALRTLDLRRNSLTALPQRVVSEQPLRGLQTIYLSQNPYDCCGVEGWGALQQHFKTVADLSMVTCNLSSKIVRVVELPEGLPQGCKWEQVDTGLFYLVLILPSCLTLLVACTVVFLTFKKPLLQVIKSRCHWSSIY
uniprot
proteins
function
FUNCTION: Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (PubMed:29909984). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1 (PubMed:29909984). TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS (PubMed:29909984). Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (Probable). {ECO:0000269|PubMed:29909984, ECO:0000305|PubMed:24550525, ECO:0000305|PubMed:29909984}.
uniprot
proteins
mass_dalton
77140
uniprot
proteins
mutagenesis
MUTAGEN 219; /note="C->A: Abolishes formation of disulfide bonds and ability to interact with TGFB1; when associated with A-363."; /evidence="ECO:0000269|PubMed:29909984"; MUTAGEN 363; /note="C->A: Abolishes formation of disulfide bonds and ability to interact with TGFB1; when associated with A-219."; /evidence="ECO:0000269|PubMed:29909984
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:29909984}.
uniprot
proteins
protein_family
LRRC32/LRRC33 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24550525
uniprot
proteins
pubmed
24739962
uniprot
proteins
pubmed
28459434
uniprot
proteins
pubmed
29909984
uniprot
proteins
sequence_length
693
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24739962, ECO:0000269|PubMed:29909984}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24739962}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 652..672; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins