KLHDC10
entrez
23008
canonical
uniprot
Q6PID8
canonical
ensembl
ENSG00000128607
resolver
ensp
ENSP00000334140
resolver
ensp
ENSP00000521977
resolver
genesymbol
KLHDC10
resolver
genesymbol_syn
KIAA0265
resolver
hgnc
HGNC:22194
resolver
uniprot
Q86Y99
resolver
uniprot
Q92554
resolver
uniprot_entry
KLD10_HUMAN
resolver
uniprot_sec
Q86Y99
resolver
uniprot_sec
Q92554
resolver
amino_acid_sequence
MSAAQGWDRNRRRGGGAAGAGGGGSGAGGGSGGSGGRGTGQLNRFVQLSGRPHLPGKKKIRWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNLANLSRTQLLHLGLTQGLIERLK
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C-terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:33909987). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:33909987, PubMed:39548056). The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) or an alanine tail (CAT tail) at the C-terminus, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:33909987). The CRL2(KLHDC10) complex is involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: CRL2(KLHDC10) acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (PubMed:33909987). Participates in the oxidative stress-induced cell death through MAP3K5 activation (PubMed:23102700). Inhibits PPP5C phosphatase activity on MAP3K5 (PubMed:23102700). Acts as a regulator of necroptosis (By similarity). {ECO:0000250|UniProtKB:Q6PAR0, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:33909987, ECO:0000269|PubMed:39548056}.
uniprot
proteins
mass_dalton
49098
uniprot
proteins
mutagenesis
MUTAGEN 409; /note="A->P: Loss of interaction with CUL2. No effect on MAP3K5 activation."; /evidence="ECO:0000269|PubMed:23102700
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:33909987, ECO:0000269|PubMed:39548056}.
uniprot
proteins
protein_family
KLHDC10 family
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
14962666
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23102700
uniprot
proteins
pubmed
29779948
uniprot
proteins
pubmed
33909987
uniprot
proteins
pubmed
39548056
uniprot
proteins
pubmed
9039502
uniprot
proteins
sequence_length
442
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23102700}. Cytoplasm {ECO:0000269|PubMed:23102700}.
uniprot
proteins