ACOT13
entrez
55856
canonical
uniprot
Q9NPJ3
canonical
ensembl
ENSG00000112304
resolver
ensp
ENSP00000230048
resolver
ensp
ENSP00000445552
resolver
genesymbol
ACOT13
resolver
genesymbol_syn
THEM2
resolver
hgnc
HGNC:20999
resolver
uniprot
F5H2L4
resolver
uniprot
O95549
resolver
uniprot_entry
ACO13_HUMAN
resolver
uniprot_sec
F5H2L4
resolver
uniprot_sec
O95549
resolver
amino_acid_sequence
MTSMTQSLREVIKAMTKARNFERVLGKITLVSAAPGKVICEMKVEEEHTNAIGTLHGGLTATLVDNISTMALLCTERGAPGVSVDMNITYMSPAKLGEDIVITAHVLKQGKTLAFTSVDLTNKATGKLIAQGRHTKHLGN
uniprot
proteins
ec_number
3.1.2.-
uniprot
proteins
ec_number
3.1.2.2
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16934754, PubMed:19170545). Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (By similarity) (PubMed:16934754, PubMed:19170545). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity) (PubMed:16934754, PubMed:19170545). May play a role in controlling adaptive thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q9CQR4, ECO:0000269|PubMed:16934754, ECO:0000269|PubMed:19170545}.
uniprot
proteins
mass_dalton
14960
uniprot
proteins
mutagenesis
MUTAGEN 50; /note="N->A: Reduced acyl-CoA hydrolase activity."; /evidence="ECO:0000269|PubMed:19170545"; MUTAGEN 56; /note="H->A: Decreases affinity for substrate."; /evidence="ECO:0000269|PubMed:19170545"; MUTAGEN 65; /note="D->A: Loss of acyl-CoA hydrolase activity."; /evidence="ECO:0000269|PubMed:16934754, ECO:0000269|PubMed:19170545"; MUTAGEN 65; /note="D->E,N: Reduced acyl-CoA hydrolase activity."; /evidence="ECO:0000269|PubMed:16934754, ECO:0000269|PubMed:19170545"; MUTAGEN 83; /note="S->A: Reduced acyl-CoA hydrolase activity."; /evidence="ECO:0000269|PubMed:19170545
uniprot
proteins
protein_family
Thioesterase PaaI family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16934754
uniprot
proteins
pubmed
19170545
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
140
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9CQR4}. Mitochondrion {ECO:0000250|UniProtKB:Q9CQR4}. Nucleus {ECO:0000250|UniProtKB:Q9CQR4}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9CQR4}. Note=During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin. {ECO:0000250|UniProtKB:Q9CQR4}.
uniprot
proteins