ATF1
entrez
466
canonical
uniprot
P18846
canonical
ensembl
ENSG00000123268
resolver
ensp
ENSP00000262053
resolver
ensp
ENSP00000532832
resolver
ensp
ENSP00000532834
resolver
ensp
ENSP00000532835
resolver
ensp
ENSP00000532836
resolver
ensp
ENSP00000532838
resolver
ensp
ENSP00000532840
resolver
ensp
ENSP00000599879
resolver
ensp
ENSP00000786806
resolver
genesymbol
ATF1
resolver
hgnc
HGNC:783
resolver
uniprot
B4DRF9
resolver
uniprot
P25168
resolver
uniprot
Q9H4A8
resolver
uniprot_entry
ATF1_HUMAN
resolver
uniprot_sec
B4DRF9
resolver
uniprot_sec
P25168
resolver
uniprot_sec
Q9H4A8
resolver
amino_acid_sequence
MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSNKSV
uniprot
proteins
disease_involvement
DISEASE: Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=The gene represented in this entry may be involved in disease pathogenesis. Chromosomal aberrations involving ATF1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein.
uniprot
proteins
function
FUNCTION: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}.
uniprot
proteins
mass_dalton
29233
uniprot
proteins
mutagenesis
MUTAGEN 63; /note="S->A: Impaired CDK3-mediated phosphorylation and altered transactivation and transcriptional activities."; /evidence="ECO:0000269|PubMed:18794154
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:8621702}.
uniprot
proteins
protein_family
ATF subfamily
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
11063792
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15884099
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
1655749
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18794154
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20980392
uniprot
proteins
pubmed
2196176
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2516827
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29983246
uniprot
proteins
pubmed
8621702
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29983246}.
uniprot
proteins