Nbr1
entrez
17966
canonical
uniprot
P97432
canonical
ensembl
ENSMUSG00000017119
resolver
ensp
ENSMUSP00000099387
resolver
ensp
ENSMUSP00000099388
resolver
ensp
ENSMUSP00000102826
resolver
ensp
ENSMUSP00000102831
resolver
ensp
ENSMUSP00000102836
resolver
ensp
ENSMUSP00000133619
resolver
ensp
ENSMUSP00000288914
resolver
ensp
ENSMUSP00000288917
resolver
ensp
ENSMUSP00000288918
resolver
ensp
ENSMUSP00000288922
resolver
ensp
ENSMUSP00000288931
resolver
enst
ENSMUST00000103098
resolver
enst
ENSMUST00000103099
resolver
enst
ENSMUST00000107208
resolver
enst
ENSMUST00000107213
resolver
enst
ENSMUST00000107218
resolver
enst
ENSMUST00000123558
resolver
genesymbol
Nbr1
resolver
genesymbol_syn
M17s2
resolver
genesymbol_syn
mKIAA0049
resolver
uniprot
A1L329
resolver
uniprot
A2A4N5
resolver
uniprot
A2A4N8
resolver
uniprot
G3UXB2
resolver
uniprot
Q05BC8
resolver
uniprot
Q6ZQK3
resolver
uniprot
Q9JIH9
resolver
uniprot_entry
A1L329_MOUSE
resolver
uniprot_entry
A2A4N5_MOUSE
resolver
uniprot_entry
A2A4N8_MOUSE
resolver
uniprot_entry
G3UXB2_MOUSE
resolver
uniprot_entry
NBR1_MOUSE
resolver
uniprot_entry
Q05BC8_MOUSE
resolver
uniprot_entry
Q6ZQK3_MOUSE
resolver
uniprot_sec
Q9JIH9
resolver
amino_acid_sequence
MEPQVTLNVTFKNETQSFLVSDPENTTWADVEAMVKVSFDLNTIQIKYLDEENEEISINSQGEYEEALKMANIKQGNQLQMQVHEGYHVVDEALPKNVVENQAAARTGKKPLAHYSSLVRVLGSDMKTTEEPAPEQCSSAPCDTDQPQDKPPDWFTSYLEMFREQVVKETVEKLEQRLQEKLVLQKPLLSSSPTEVSMPISEETLFLPENQFSWHIACSHCQKRIVGVRYQCSLCPSYNICEDCEAGPYTHDTNHVLLKLRRPVVISSEPFFYSKYSAPRLPAALEQVRLQKQVDKNFVKAEKQRLRAEKKQRKAEVKELKKQLKLHRKIHLWNSIHGLQSPKSPLGRPESLLQSNTLMLPLQPCAPVMPTLSAAFVDENLPDGTHLQPGTKFIKHWRMKNTGNVKWNTDTKLKFMWGNLTLASTEKKDVLVPCLKAGHVGVVSVEFIAPTLEGTYTSHWRLSHKGQQFGPRVWCSIIVDPFPSSESPDNVEGDRISSSKADDFSCEQEEAFLLAEEEIPLGEVTKQTEGTGASASQKTRRAASERELYIPSVDLLTAQDLLSFELLDINIVQELERVPHNTPVDMTPCMSPLPHDSPLIEKPGLGQIQEESEGAGFKAPPDSTVSAKRKAETPASVEETEEDLSGTQFVCETVIRSLTLDAAPDHNPPCRQRSPQRELQLYSTEGQQPLVLPGFCRKDSSLKFALPEEGPRGDEREEIVHIVEEEVVEEEEEVQDEEVQSQSSASSEDYIIILPECFDTSRPLGDSMYSSALSQPGLERGAEGEPGIESGLEPTEARERLPERESQPQEQSISDILTTSQPLDTVPLVPEVAGLPAALSRSAPCGQCESSGVDSPGVDSPATMHEVPPAPDDIRGEPRGSTGLANSRQRSCDHSRHHNGSSIAGGLVKGALSVAASAYKALFSGPPVTAQPIVSEDQTTALMAHLFEMGFCDRQLNLRLLRKHNYNILQVVTELLQVNNNDWYSHRY
uniprot
proteins
function
FUNCTION: Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:31916398, PubMed:34374750). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (By similarity). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (PubMed:31916398). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (PubMed:31916398). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (PubMed:34374750). {ECO:0000250|UniProtKB:Q14596, ECO:0000269|PubMed:31916398, ECO:0000269|PubMed:34374750}.
uniprot
proteins
mass_dalton
109958
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3A; this phosphorylation inhibits NBR1 involvement in the formation of ubiquitinated protein aggregates. {ECO:0000250|UniProtKB:Q14596}.
uniprot
proteins
pubmed
11179671
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31916398
uniprot
proteins
pubmed
34374750
uniprot
proteins
pubmed
8975707
uniprot
proteins
sequence_length
988
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31916398}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q14596}. Lysosome {ECO:0000250|UniProtKB:Q14596}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q501R9}. Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (By similarity). {ECO:0000250|UniProtKB:Q14596, ECO:0000250|UniProtKB:Q501R9, ECO:0000269|PubMed:31916398}.
uniprot
proteins