Scn3a
entrez
20269
canonical
uniprot
A2ASI5
canonical
ensembl
ENSMUSG00000057182
resolver
ensp
ENSMUSP00000097647
resolver
ensp
ENSMUSP00000172837
resolver
genesymbol
Scn3a
resolver
uniprot
A0A0R5RP23
resolver
uniprot
A0A0R5RP41
resolver
uniprot
Q3UF73
resolver
uniprot_entry
Q3UF73_MOUSE
resolver
uniprot_entry
SCN3A_MOUSE
resolver
uniprot_sec
A0A0R5RP23
resolver
uniprot_sec
A0A0R5RP41
resolver
amino_acid_sequence
MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDIDDENKPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYVSKKTFVVLNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFEINTTSYFNGTMDSNGTFVNVTMSTFNWKDYIADDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNHRPEGDRFPKSESEDSVKRRSFLFSLDGNPLSGDKKLCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSESRRDSLFVPHRPGERRNSNGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAMSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDSWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINEDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKIRECFRKAFFRKPKVIEIHEGNKIDSCMSNNTGVVEISKELNYLKDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVAPPREGEQAEIEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGSMFDMSEVNNFSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSKYMTLVLSRINLVFIVLFTGEFLLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDAIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNYRCYLLKQRLKNISNTYDKETIKGRIVLPIKGDMVIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEKFEKDKPEKESKGKEV
uniprot
proteins
function
FUNCTION: Pore-forming subunit of Nav1.3, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:29142310). In some secretory cell types, it also participates in cell excitability through membrane depolarization and regulates cells responsiveness to stimuli triggering secretion. For instance, it controls the release of serotonin/5-hydroxytryptamine by enterochromaffin cells and is required for both glucagon- and glucose-induced insulin secretion in pancreatic endocrine cells (PubMed:25172946, PubMed:29142310). {ECO:0000269|PubMed:25172946, ECO:0000269|PubMed:29142310}.
uniprot
proteins
mass_dalton
220880
uniprot
proteins
post_translational_modification
PTM: May be ubiquitinated by NEDD4L; which would promote its endocytosis. {ECO:0000250|UniProtKB:Q9NY46}.; PTM: Phosphorylation at Ser-1453 in a highly conserved cytoplasmic loop slows inactivation of the channel and reduces peak sodium currents. {ECO:0000250|UniProtKB:Q14524}.
uniprot
proteins
protein_family
Nav1.3/SCN3A subfamily
uniprot
proteins
protein_family
Sodium channel (TC 1.A.1.10) family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25172946
uniprot
proteins
pubmed
25459751
uniprot
proteins
pubmed
25937544
uniprot
proteins
pubmed
29142310
uniprot
proteins
sequence_length
1947
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NY46}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NY46}. Basal cell membrane {ECO:0000269|PubMed:29142310}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NY46}. Note=In enterochromaffin cells, localized highly asymmetrically, almost exclusively at the basal side. {ECO:0000269|PubMed:29142310}.
uniprot
proteins
transmembrane_region
TRANSMEM 129..146; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 153..174; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 189..206; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 214..235; /note="Helical; Name=S4 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 250..269; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 398..424; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 713..730; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 739..763; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 774..793; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 798..816; /note="Helical; Name=S4 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 835..855; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 908..934; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 1158..1178; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 1191..1212; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 1219..1244; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 1254..1272; /note="Helical; Name=S4 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 1286..1308; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 1395..1420; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 1479..1497; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 1506..1529; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 1540..1557; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 1570..1592; /note="Helical; Name=S4 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 1606..1629; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q9NY46"; TRANSMEM 1697..1722; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q9NY46
uniprot
proteins