Spag9
entrez
70834
canonical
uniprot
Q58A65
canonical
ensembl
ENSMUSG00000020859
resolver
ensp
ENSMUSP00000042271
resolver
ensp
ENSMUSP00000075115
resolver
ensp
ENSMUSP00000090452
resolver
ensp
ENSMUSP00000099457
resolver
ensp
ENSMUSP00000268794
resolver
ensp
ENSMUSP00000268796
resolver
ensp
ENSMUSP00000268798
resolver
ensp
ENSMUSP00000268799
resolver
ensp
ENSMUSP00000268801
resolver
ensp
ENSMUSP00000268802
resolver
enst
ENSMUST00000092777
resolver
enst
ENSMUST00000103168
resolver
genesymbol
Spag9
resolver
genesymbol_syn
Jip4
resolver
genesymbol_syn
Jsap2
resolver
genesymbol_syn
Kiaa0516
resolver
genesymbol_syn
Mapk8ip4
resolver
uniprot
A0A0R4J196
resolver
uniprot
B8X349
resolver
uniprot
E9PUD1
resolver
uniprot
Q3UH77
resolver
uniprot
Q3UHF0
resolver
uniprot
Q58VQ4
resolver
uniprot
Q5NC70
resolver
uniprot
Q5NC78
resolver
uniprot
Q6A057
resolver
uniprot
Q6PA03
resolver
uniprot
Q6PAS3
resolver
uniprot
Q8CJC2
resolver
uniprot_entry
A0A0R4J196_MOUSE
resolver
uniprot_entry
B8X349_MOUSE
resolver
uniprot_entry
E9PUD1_MOUSE
resolver
uniprot_entry
JIP4_MOUSE
resolver
uniprot_entry
Q6PA03_MOUSE
resolver
uniprot_sec
Q3UH77
resolver
uniprot_sec
Q3UHF0
resolver
uniprot_sec
Q58VQ4
resolver
uniprot_sec
Q5NC70
resolver
uniprot_sec
Q5NC78
resolver
uniprot_sec
Q6A057
resolver
uniprot_sec
Q6PAS3
resolver
uniprot_sec
Q8CJC2
resolver
amino_acid_sequence
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLEATAHSRIRKERPISLGIFPLPAGDGLLTPDTQKGGETPGSEQWKFQELSQPRSHTSLKVSHSPEPPKAVEQEDELSDISQGGSKATTPASTANSDVSAIPPDTPSKEDNEGFVKGTDTSNKSEISKHIEVQVAQETRNVSTESGENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNVVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEDKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNATKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVANGQGETKMKNLPVPVYLRPLDEKDASMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDIAGLDTEGSKQRSASQSSLDKLDQELKEQQKEFKNQEELSSQVWICTSTHSTTKVIIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEELSESGQVDKASLCGSMTSNSSAEMDSLLGGITVVGCSTEGLTGAATSPSTNGASPVIEKPPEMETENSEVDENIPTAEEATEATEGNAGSTEDTVDISQPGVYTEHVFTDPLGVQIPEDLSPVFQSSNDSDVYKDQISVLPNEQDLAREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGTPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSGGADLTADKAGSSAQEPSSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMCGNE
uniprot
proteins
function
FUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12391307, PubMed:15767678). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (By similarity). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (PubMed:19056739). {ECO:0000250|UniProtKB:O60271, ECO:0000269|PubMed:12391307, ECO:0000269|PubMed:15767678, ECO:0000269|PubMed:19056739}.
uniprot
proteins
mass_dalton
146219
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK8 and MAPK14. {ECO:0000269|PubMed:15767678}.
uniprot
proteins
protein_family
JIP scaffold family
uniprot
proteins
pubmed
12391307
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15767678
uniprot
proteins
pubmed
15987681
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19056739
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1321
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12391307, ECO:0000269|PubMed:15767678, ECO:0000269|PubMed:19056739}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12391307, ECO:0000269|PubMed:19056739}. Lysosome membrane {ECO:0000250|UniProtKB:O60271}. Note=Perinuclear distribution in response to stress signals such as UV radiation. {ECO:0000269|PubMed:12391307}.
uniprot
proteins