Fbxw7-as1
entrez
446170
canonical
uniprot
D3ZGZ6
canonical
ensembl
ENSRNOG00000033147
resolver
ensp
ENSRNOP00000039897
resolver
enst
ENSRNOT00000042146
resolver
genesymbol
Fbxw7-as1
resolver
genesymbol_syn
Dear
resolver
uniprot
Q6BDA5
resolver
uniprot_entry
DESPR_RAT
resolver
uniprot_sec
Q6BDA5
resolver
amino_acid_sequence
MSTFYVTAVPKSHSSLPKCQAMMSRTLLTGMAMYLDSSHAGAASMQVSWPPLLTSLGSKEMKSRWNWGSITCIMCFTCVGSQLSMSSSKASNFSGPLQLYQRGIGHITNPYRRPPAPAWPCSSSGTT
uniprot
proteins
function
FUNCTION: In the Dahl salt-resistant strain, acts as a dual receptor for both endothelin-1 and the signal sequence of vascular endothelial growth factor A and does not act as a receptor for angiotensin-2 (PubMed:15561758). Does not bind the VEGFA mature protein (By similarity). In the Dahl salt-sensitive strain, acts as a dual endothelin-1/angiotensin-2 receptor that is functionally coupled to a calcium-mobilizing transduction system, responding equivalently to both endothelin-1/EDN1 and angiotensin-2 peptides in a highly specific manner (PubMed:15561758, PubMed:9508787). May play a role in angiogenesis with a significant role in cardiovascular and neural development (By similarity). {ECO:0000250|UniProtKB:B0L3A2, ECO:0000250|UniProtKB:Q2QKR2, ECO:0000269|PubMed:15561758, ECO:0000269|PubMed:9508787}.
uniprot
proteins
mass_dalton
13733
uniprot
proteins
mutagenesis
MUTAGEN 64; /note="R->G: Abolishes binding with EDN1 without affecting angiotensin-2 peptide binding."; /evidence="ECO:0000269|PubMed:9508787"; MUTAGEN 65; /note="W->G: Abolishes binding with EDN1. Affects binding with angiotensin-2 peptide."; /evidence="ECO:0000269|PubMed:9508787
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15561758
uniprot
proteins
pubmed
9508787
uniprot
proteins
sequence_length
127
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9508787}; Single-pass membrane protein {ECO:0000250|UniProtKB:B0L3A2, ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 70..88; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins