Htr5a
entrez
25689
canonical
uniprot
P35364
canonical
ensembl
ENSRNOG00055005569
resolver
ensembl
ENSRNOG00060023141
resolver
ensembl
ENSRNOG00065004484
resolver
ensp
ENSRNOP00055006812
resolver
ensp
ENSRNOP00060033052
resolver
ensp
ENSRNOP00065004568
resolver
enst
ENSRNOT00055008947
resolver
enst
ENSRNOT00060040038
resolver
enst
ENSRNOT00065006513
resolver
genesymbol
Htr5a
resolver
genesymbol_syn
5ht5a
resolver
uniprot_entry
5HT5A_RAT
resolver
amino_acid_sequence
MDLPINLTSFSLSTPSTLEPNRSLDTEALRTSQSFLSAFRVLVLTLLGFLAAATFTWNLLVLATILRVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRARKRVSNVMILLTWALSAVISLAPLLFGWGETYSELSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYKAAKFRMGSRKTNSVSPIPEAVEVKDASQHPQMVFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDIPALWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:7682702). Also functions as a receptor for ergot alkaloid derivatives and other psychoactive substances (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Htr5a is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (By similarity). {ECO:0000250|UniProtKB:P47898, ECO:0000269|PubMed:7682702}.
uniprot
proteins
mass_dalton
40673
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
7682702
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P47898}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..63; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 77..103; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 115..137; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 156..176; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 199..220; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 288..312; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 315..339; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P47898
uniprot
proteins