Traf6
entrez
22034
canonical
uniprot
P70196
canonical
ensembl
ENSMUSG00000027164
resolver
ensp
ENSMUSP00000004949
resolver
ensp
ENSMUSP00000255073
resolver
genesymbol
Traf6
resolver
uniprot
Q6P9M0
resolver
uniprot
Q8BLV2
resolver
uniprot_entry
TRAF6_MOUSE
resolver
uniprot_sec
Q6P9M0
resolver
uniprot_sec
Q8BLV2
resolver
amino_acid_sequence
MSLLNCENSCGSSQSSSDCCAAMAASCSAAVKDDSVSGSASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLTVKCPNKGCLQKMELRHLEDHQVHCEFALVNCPQCQRPFQKCQVNTHIIEDCPRRQVSCVNCAVSMAYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPIPCTFSVFGCHEKMQRNHLARHLQENTQLHMRLLAQAVHNVNLALRPCDAASPSRGCRPEDPNYEETIKQLESRLVRQDHQIRELTAKMETQSMYVGELKRTIRTLEDKVAEMEAQQCNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEALIRQNHEEVMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQGTFIKDDTLLVRCEVSTRFDMGGLRKEGFQPRSTDAGV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2 (PubMed:15322147, PubMed:17633018). Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity). Leads to the activation of NF-kappa-B and JUN. Seems to also play a role in dendritic cells (DCs) maturation and/or activation (PubMed:14499111). Represses c-Myb-mediated transactivation, in B-lymphocytes (By similarity). Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (PubMed:10215628, PubMed:10421844). Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation (PubMed:10421844, PubMed:17092936). Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (PubMed:12881420). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by initiating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: TRAF6 catalyzes initial 'Lys-63'-linked-polyubiquitin chains that are then branched via 'Lys-48'-linked polyubiquitin by HUWE1 (By similarity). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (By similarity). Also participates in the TCR signaling by ubiquitinating LAT (By similarity). {ECO:0000250|UniProtKB:Q9Y4K3, ECO:0000269|PubMed:10215628, ECO:0000269|PubMed:10421844, ECO:0000269|PubMed:12881420, ECO:0000269|PubMed:14499111, ECO:0000269|PubMed:15322147, ECO:0000269|PubMed:17092936, ECO:0000269|PubMed:17633018}.
uniprot
proteins
mass_dalton
60070
uniprot
proteins
mutagenesis
MUTAGEN 327; /note="K->R: Abolished ubiquitination by the SCF(FBXL2) complex."; /evidence="ECO:0000269|PubMed:23542741"; MUTAGEN 363; /note="W->A: Decreased interaction with FBXL2."; /evidence="ECO:0000269|PubMed:23542741
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9Y4K3}.
uniprot
proteins
post_translational_modification
PTM: Sumoylated on Lys-124, Lys-142 and Lys-461 with SUMO1. Sumoylated on Lys-461 by TRIM28 in the nucleus, SUMOylation regulates the nucleo-cytoplasmic shuttling of TRAF6. {ECO:0000250|UniProtKB:Q9Y4K3}.; PTM: Polyubiquitinated on Lys-124 by TRAF3IP2; after cell stimulation with IL17A (By similarity). Polyubiquitinated; after cell stimulation with IL1B or TGFB. This ligand-induced cell stimulation leads to dimerization/oligomerization of TRAF6 molecules, followed by auto-ubiquitination which involves UBE2N and UBE2V1 and leads to TRAF6 activation. This 'Lys-63' site-specific poly-ubiquitination appears to be associated with the activation of signaling molecules. Endogenous autoubiquitination occurs only for the cytoplasmic form. Deubiquitinated by USP10 in a TANK-dependent manner, leading to the negative regulation of NF-kappa-B signaling upon DNA damage. LRRC19 induces 'Lys-63' ubiquitination (PubMed:25026888). Ubiquitinated at Lys-327 by the SCF(FBXL2) complex, leading to its degradation by the proteasome (PubMed:23542741). {ECO:0000250|UniProtKB:Q9Y4K3, ECO:0000269|PubMed:23542741, ECO:0000269|PubMed:25026888}.
uniprot
proteins
protein_family
A subfamily
uniprot
proteins
protein_family
TNF receptor-associated factor family
uniprot
proteins
pubmed
10215628
uniprot
proteins
pubmed
10421844
uniprot
proteins
pubmed
10747026
uniprot
proteins
pubmed
10748240
uniprot
proteins
pubmed
11244088
uniprot
proteins
pubmed
12060722
uniprot
proteins
pubmed
12881420
uniprot
proteins
pubmed
14499111
uniprot
proteins
pubmed
15322147
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15705807
uniprot
proteins
pubmed
16079148
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16951688
uniprot
proteins
pubmed
17092936
uniprot
proteins
pubmed
17633018
uniprot
proteins
pubmed
18849341
uniprot
proteins
pubmed
21435586
uniprot
proteins
pubmed
22424771
uniprot
proteins
pubmed
23542741
uniprot
proteins
pubmed
25026888
uniprot
proteins
pubmed
26553469
uniprot
proteins
pubmed
27330028
uniprot
proteins
pubmed
8910514
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y4K3}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9Y4K3}. Nucleus {ECO:0000250|UniProtKB:Q9Y4K3}. Lipid droplet {ECO:0000269|PubMed:21435586}. Note=RSAD2/viperin recruits it to the lipid droplet.
uniprot
proteins