Rad1
entrez
19355
canonical
uniprot
Q9QWZ1
canonical
ensembl
ENSMUSG00000022248
resolver
ensp
ENSMUSP00000022856
resolver
ensp
ENSMUSP00000098338
resolver
ensp
ENSMUSP00000255450
resolver
ensp
ENSMUSP00000340829
resolver
genesymbol
Rad1
resolver
genesymbol_syn
Rec1
resolver
uniprot
O70452
resolver
uniprot
O88391
resolver
uniprot
Q3TGU1
resolver
uniprot
Q3UG66
resolver
uniprot
Q9QWZ3
resolver
uniprot_entry
RAD1_MOUSE
resolver
uniprot_sec
O70452
resolver
uniprot_sec
O88391
resolver
uniprot_sec
Q3TGU1
resolver
uniprot_sec
Q3UG66
resolver
uniprot_sec
Q9QWZ3
resolver
amino_acid_sequence
MPLLTQYNEEEYEQYCLVASLDNVRNLSTVLKAIHFREHATCFATKNGIKVTVENAKCVQANAFIQADVFQEFVIQEESVTFRINLTILLDCLSIFGSSPTPGTLTALRMCYQGYGHPLMLFLEEGGVVTVCKITTQEPEETLDFDFCSTNVMNKIILQSEGLREAFSELDMTGDVLQITVSPDKPYFRLSTFGNAGNSHLDYPKDSDLVEAFHCDKTQVNRYKLSLLKPSTKALALSCKVSIRTDNRGFLSLQYMIRNEDGQICFVEYYCCPDEEVPES
uniprot
proteins
function
FUNCTION: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. {ECO:0000250|UniProtKB:O60671}.
uniprot
proteins
mass_dalton
31610
uniprot
proteins
protein_family
Rad1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9660799
uniprot
proteins
pubmed
9705507
uniprot
proteins
pubmed
9716408
uniprot
proteins
pubmed
9828137
uniprot
proteins
pubmed
9878245
uniprot
proteins
sequence_length
280
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O60671}.
uniprot
proteins