CCR4
entrez
1233
canonical
uniprot
P51679
canonical
ensembl
ENSG00000183813
resolver
ensp
ENSP00000332659
resolver
ensp
ENSP00000520802
resolver
enst
ENST00000330953
resolver
enst
ENST00000718415
resolver
genesymbol
CCR4
resolver
genesymbol_syn
CMKBR4
resolver
hgnc
HGNC:1605
resolver
uniprot
A0A024R2J7
resolver
uniprot
A0N0Q1
resolver
uniprot
Q9ULY6
resolver
uniprot
Q9ULY7
resolver
uniprot_entry
A0N0Q1_HUMAN
resolver
uniprot_entry
CCR4_HUMAN
resolver
uniprot_sec
A0A024R2J7
resolver
uniprot_sec
Q9ULY6
resolver
uniprot_sec
Q9ULY7
resolver
amino_acid_sequence
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
uniprot
proteins
function
FUNCTION: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. {ECO:0000269|PubMed:10466728, ECO:0000269|PubMed:10754297, ECO:0000269|PubMed:16137713, ECO:0000269|PubMed:9169480, ECO:0000269|PubMed:9430724}.
uniprot
proteins
mass_dalton
41403
uniprot
proteins
post_translational_modification
PTM: In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2. {ECO:0000269|PubMed:10754297}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10466728
uniprot
proteins
pubmed
10754297
uniprot
proteins
pubmed
11196669
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16137713
uniprot
proteins
pubmed
7642634
uniprot
proteins
pubmed
9169480
uniprot
proteins
pubmed
9430724
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 40..67; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 78..98; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 112..133; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 151..175; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 207..226; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 243..267; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 285..308; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins