SLN
entrez
6588
canonical
uniprot
O00631
canonical
ensembl
ENSG00000170290
resolver
ensp
ENSP00000304707
resolver
ensp
ENSP00000434189
resolver
ensp
ENSP00000435380
resolver
ensp
ENSP00000630812
resolver
ensp
ENSP00000630813
resolver
ensp
ENSP00000630814
resolver
ensp
ENSP00000630815
resolver
enst
ENST00000305991
resolver
enst
ENST00000525934
resolver
enst
ENST00000531293
resolver
enst
ENST00000960753
resolver
enst
ENST00000960754
resolver
enst
ENST00000960755
resolver
enst
ENST00000960756
resolver
genesymbol
SLN
resolver
hgnc
HGNC:11089
resolver
uniprot
A0A158RFT9
resolver
uniprot
Q6ICV3
resolver
uniprot_entry
A0A158RFT9_HUMAN
resolver
uniprot_entry
SARCO_HUMAN
resolver
uniprot_sec
Q6ICV3
resolver
amino_acid_sequence
MGINTRELFLNFTIVLITVILMWLLVRSYQY
uniprot
proteins
function
FUNCTION: Reversibly inhibits the activity of ATP2A1/SERCA1 and ATP2A2/SERCA2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:11781085, PubMed:9575189). Also inhibits the activity of ATP2A3/SERCA3 (By similarity). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q9CQD6, ECO:0000269|PubMed:11781085, ECO:0000269|PubMed:9575189}.
uniprot
proteins
mass_dalton
3762
uniprot
proteins
protein_family
Sarcolipin family
uniprot
proteins
pubmed
11781085
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28890335
uniprot
proteins
pubmed
36523160
uniprot
proteins
pubmed
9367679
uniprot
proteins
pubmed
9575189
uniprot
proteins
sequence_length
31
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:11781085, ECO:0000269|PubMed:9575189}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P42532}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..26; /note="Helical
uniprot
proteins