A2ARP9
uniprot
A2ARP9
canonical
activity_regulation
ACTIVITY REGULATION: In contrast to the human ortholog, not activated by progesterone (PubMed:21412339). Activated by intracellular alkalinization (By similarity). {ECO:0000250|UniProtKB:Q96P56, ECO:0000269|PubMed:21412339}.
uniprot
proteins
amino_acid_sequence
MAQEQGHFQLLRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPSYQQKLMSGDQEQLVRFSIKPRRMGHITHSRRLLSRLRVRCSRMPPLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILLSFIVEILLMWLASFSLFWKDAWNVFDFFVTLLSLLPELVVLLGVPAHSVWLQLLRVCRVLRSLKLFARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFFREYSRSTIEGLEYNMFFSDLLNSLVTVFILFTLDHWYAVLQDIWKVPESSRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRSELSEEMSHLEVQYKADMFKQQIIQRRQHSESLRGTSLGKVSEDIIETSDASDDDDDDDDDDDDDDDDDDDKSDATESDNEESDSENSESENSESEKIDPEKDYAKKSYPEKSHPEKSYPEKSHPEKSYPEKSHPKKSYDEQAEAEKVKEESKEKAYPVSHSISSHGSTAADTAFLENLDWETLVHENLPGLMDMDQDDRIVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMSFEDK
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. {ECO:0000269|PubMed:14657366, ECO:0000269|PubMed:16036917, ECO:0000269|PubMed:17174296, ECO:0000269|PubMed:21412339}.
uniprot
proteins
mass_dalton
68572
uniprot
proteins
protein_family
Cation channel sperm-associated (TC 1.A.1.19) family
uniprot
proteins
pubmed
11675491
uniprot
proteins
pubmed
14657366
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16036917
uniprot
proteins
pubmed
17174296
uniprot
proteins
pubmed
17347248
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21224844
uniprot
proteins
pubmed
21412339
uniprot
proteins
pubmed
34225353
uniprot
proteins
pubmed
34998468
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:11675491}; Multi-pass membrane protein {ECO:0000269|PubMed:34225353}.
uniprot
proteins
transmembrane_region
TRANSMEM 107..129; /note="Helical; Name=Segment S1"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 139..164; /note="Helical; Name=Segment S2"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 174..198; /note="Helical; Name=Segment S3"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 202..220; /note="Helical; Name=Segment S4"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 238..260; /note="Helical; Name=Segment S5"; /evidence="ECO:0000269|PubMed:34225353"; TRANSMEM 313..339; /note="Helical; Name=Segment S6"; /evidence="ECO:0000269|PubMed:34225353
uniprot
proteins