Otc
entrez
18416
canonical
uniprot
P11725
canonical
ensembl
ENSMUSG00000031173
resolver
ensp
ENSMUSP00000056152
resolver
ensp
ENSMUSP00000111190
resolver
ensp
ENSMUSP00000348706
resolver
enst
ENSMUST00000049910
resolver
enst
ENSMUST00000115528
resolver
genesymbol
Otc
resolver
uniprot
F6XSJ2
resolver
uniprot
Q543H3
resolver
uniprot
Q8R1A8
resolver
uniprot_entry
F6XSJ2_MOUSE
resolver
uniprot_entry
OTC_MOUSE
resolver
uniprot_entry
Q543H3_MOUSE
resolver
uniprot_entry
Q8R1A8_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Negatively regulated by lysine acetylation. {ECO:0000250|UniProtKB:P00480}.
uniprot
proteins
amino_acid_sequence
MLSNLRILLNNAALRKGHTSVVRHFWCGKPVQSQVQLKGRDLLTLKNFTGEEIQYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFALLGGHPSFLTTQDIHLGVNESLTDTARVLSSMTDAVLARVYKQSDLDTLAKEASIPIVNGLSDLYHPIQILADYLTLQEHYGSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQAATPKGYEPDPNIVKLAEQYAKENGTKLSMTNDPLEAARGGNVLITDTWISMGQEDEKKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWTIMAVMVSLLTDYSPVLQKPKF
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Otc are the cause of the Sparse fur (spf) phenotype. Spf mouse have an OTCase with an overall decrease in activity, and altered substrate affinity. {ECO:0000269|PubMed:3603027}.
uniprot
proteins
ec_number
2.1.3.3
uniprot
proteins
function
FUNCTION: Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion. {ECO:0000250|UniProtKB:P00480}.
uniprot
proteins
mass_dalton
39765
uniprot
proteins
pathway_participation
PATHWAY: Nitrogen metabolism; urea cycle; L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1. {ECO:0000250|UniProtKB:P00480}.
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-88 negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. {ECO:0000250|UniProtKB:P00480}.
uniprot
proteins
protein_family
Aspartate/ornithine carbamoyltransferase superfamily
uniprot
proteins
protein_family
OTCase family
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
2831503
uniprot
proteins
pubmed
3011788
uniprot
proteins
pubmed
3603027
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P00480}.
uniprot
proteins