PDE4B
entrez
5142
canonical
uniprot
Q07343
canonical
ensembl
ENSG00000184588
resolver
ensp
ENSP00000332116
resolver
ensp
ENSP00000342637
resolver
ensp
ENSP00000360084
resolver
ensp
ENSP00000392947
resolver
ensp
ENSP00000432592
resolver
genesymbol
PDE4B
resolver
genesymbol_syn
DPDE4
resolver
hgnc
HGNC:8781
resolver
uniprot
A5YW33
resolver
uniprot
O15443
resolver
uniprot
Q13945
resolver
uniprot
Q59GM8
resolver
uniprot
Q5TEK4
resolver
uniprot
Q5TEK5
resolver
uniprot
Q5TEK6
resolver
uniprot
X5DNX5
resolver
uniprot
X5DR82
resolver
uniprot_entry
PDE4B_HUMAN
resolver
uniprot_entry
Q59GM8_HUMAN
resolver
uniprot_entry
X5DNX5_HUMAN
resolver
uniprot_entry
X5DR82_HUMAN
resolver
uniprot_sec
A5YW33
resolver
uniprot_sec
O15443
resolver
uniprot_sec
Q13945
resolver
uniprot_sec
Q5TEK4
resolver
uniprot_sec
Q5TEK5
resolver
uniprot_sec
Q5TEK6
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by rolipram. {ECO:0000269|PubMed:17519386}.
uniprot
proteins
amino_acid_sequence
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
uniprot
proteins
ec_number
3.1.4.53
uniprot
proteins
function
FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978}.
uniprot
proteins
mass_dalton
83343
uniprot
proteins
mutagenesis
MUTAGEN 567..575; /note="NPTKSLELY->HPTKSLELH: Increases substrate selectivity for cGMP."; /evidence="ECO:0000269|PubMed:15260978"; MUTAGEN 567; /note="N->A: Changes substrate selectivity from cAMP-specific to dual cAMP and cGMP binding and hydrolysis; when associated with Q-575 and W-652."; /evidence="ECO:0000269|PubMed:15260978"; MUTAGEN 575; /note="Y->Q: Changes substrate selectivity from cAMP-specific to dual cAMP and cGMP binding and hydrolysis; when associated with A-567 and W-652."; /evidence="ECO:0000269|PubMed:15260978"; MUTAGEN 652; /note="Y->W: Changes substrate selectivity from cAMP-specific to dual cAMP and cGMP binding and hydrolysis; when associated with A-567 and Q-575."; /evidence="ECO:0000269|PubMed:15260978
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. {ECO:0000305|PubMed:15260978, ECO:0000305|PubMed:8392015, ECO:0000305|PubMed:9371714}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE4 subfamily
uniprot
proteins
pubmed
10846163
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15003452
uniprot
proteins
pubmed
15260978
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15576036
uniprot
proteins
pubmed
15685167
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17519386
uniprot
proteins
pubmed
17727341
uniprot
proteins
pubmed
18539455
uniprot
proteins
pubmed
8384210
uniprot
proteins
pubmed
8392015
uniprot
proteins
pubmed
8413254
uniprot
proteins
pubmed
9371714
uniprot
proteins
sequence_length
736
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform PDE4B5]: Cytoplasm {ECO:0000269|PubMed:17519386}. Cell membrane {ECO:0000269|PubMed:17519386}.
uniprot
proteins