Pom121
entrez
113975
canonical
uniprot
P52591
canonical
ensembl
ENSRNOG00000001449
resolver
ensp
ENSRNOP00000001968
resolver
enst
ENSRNOT00000001968
resolver
genesymbol
Pom121
resolver
genesymbol_syn
Nup121
resolver
uniprot
G3V659
resolver
uniprot_entry
G3V659_RAT
resolver
uniprot_entry
PO121_RAT
resolver
amino_acid_sequence
MSPAAAAADGGERRRPPLGVREGRGRTRGCGGPAGAAALGLALLGLALYLVPAAAALAWLAVGASAAWWGLSREPRGPRGLSSFVRESRRHPRPALTASPLPAKSPVNGSLCEPRSPLGGPDPAELLLMGSYLGKPGPPEPALPQDPRDRPGRRPPSRSPPSSSTAQRVHHVYPALPTPLLRPSRRPPHRDCGPLSSRFVITPRRRYPIQQAQYSLLGALPTVCWNGGHKKAVLSARNSRMVCSPVTVRIAPPDSKLFRSPMPEQILSTTLSSPSSNAPDPCAKETVLNALKEKKKRTVAEEDQLHLDGQENKRRRHDSSGSGHSAFEPLVANGVPAAFVPKPGSLKRSLASQSSDDHLNKRSRTSSVSSLTSTCTGGIPSSSRNAITSSYSSTRGVSQLWKRSGPTSSPFSSPASSRSQTPERPAKKTREEEPCHQSSSSAPLVTDKESPGEKVTDPATGKQQSLWTSPPTPGSSGQRKRKIQLLPSRRGDQLTLPPPPELGYSITAEDLDMERRASLQWFNKVLEDKTDDASTPATDTSPATSPPFTLTLPTVGPAASPASLPAPSSNPLLESLKKMQESPAPSSSEPPEAATVAAPSPPKTPSLLAPLVSPLTGPLASTSSDSKPTTTFLGLASASSATPLTDTKAPGVSQAQLCVSTPAATAPSPTPASTLFGMLSPPASSSSLATPGPACASPMFKPIFPATPKSESDNPLPTSSSAATTTPASTALPTTATATAHTFKPIFESVEPFAAMPLSPPFSLKQTTAPATTAATSAPLLTGLGTATSTVATGTTASASKPVFGFGVTTAASTASTIASTSQSILFGGAPPVTASSSAPALASIFQFGKPLAPAASVAGTSFSQSLASSAQTAASNSSGGFSGFGGTLTTSTSAPATTSQPTLTFSNTVTPTFNIPFSASAKPALPTYPGANSQPTFGATDGATKPALAPSFGSSFTFGNSVASAPSAAPAPAAFGGAAQPAFGGLKASASTFGTPASTQPAFGSTTSVFSFGSATTSGFGAAAATTQTTHSGSSSSLFGSSTPSPFTFGGSAAPAGGGGFGLSATPGTGSTSGTFSFGSGQSGTTGTTTSFGGSLSQNTLGAPSQSSPFAFSVGSTPESKPVFGGTSTPTFGQSAPAPGVGTTGSSLSFGAPSTPAQGFVGVGPFGSGAPSFSIGAGSKTPGARQRLQARRQHTRKK
uniprot
proteins
function
FUNCTION: Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).
uniprot
proteins
mass_dalton
120785
uniprot
proteins
mutagenesis
MUTAGEN 531; /note="D->A: Abolishes cleavage."; /evidence="ECO:0000269|PubMed:14729472
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by caspase-3 during apoptosis.
uniprot
proteins
protein_family
POM121 family
uniprot
proteins
pubmed
11448991
uniprot
proteins
pubmed
14729472
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8335683
uniprot
proteins
sequence_length
1199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:11448991}. Nucleus membrane {ECO:0000269|PubMed:11448991}; Single-pass membrane protein {ECO:0000269|PubMed:11448991}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11448991}; Single-pass membrane protein {ECO:0000269|PubMed:11448991}. Note=Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase.
uniprot
proteins
transmembrane_region
TRANSMEM 57..77; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins