P0C219
uniprot
P0C219
canonical
amino_acid_sequence
MPSALAIFTCRPNSHPFQERHVYLDEPIKIGRSVARCRPAQNNATFDCKVLSRNHALVWFDHKTSKFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVDVTENTRKVVTHGCIVSTIKLFLPDGMEARLRSDDVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELVALQEDKHSYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLREMNERTQEELRELANKYNGAVNEIKDLSDKLKAAEGKQEEIQQKGQAEKKELQAKIDDMEEKEQELQAKIEALQADNDFTNERLTALQVVRLEPLQEKTLKECSSLGGIQVDDFLPKINGSTEKEERLLSKSGGDCTFIHQFIECQKKKLMVQGHLTKVVEESKLSKEENQAKAKESDLSDTLSPSKEKSSDDTTDDAQMDEQDLNEPLAKVSLLKDDDLQGTQAETEAKQDTQHLRKELVEAQELARASKQKCFDLQAALLEEERKAYRNQVEESAKQIQVLQVVQLQRLHMDMENLQEEKDTEISSTRDKLLSAQDEILLLHQAAAKAVSERDTDFMSLQEELKKVRAELEGWRKAASEYEEEIRSLQSTFQLRCQQCEVQQREEATRLQGGELEKLKKEWDVLENECRSLKKENVLLSSELQRQEKELHNNSQKQSLELTSDLSILQMTRKELENQMGSLKEQHLRDEADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKDNLKLLREKGNNKPWPWMPMVAALVAVTAMVLYVPGLARASP
uniprot
proteins
function
FUNCTION: Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex. The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (By similarity). May play a role during myoblast fusion (By similarity). {ECO:0000250|UniProtKB:Q14BN4, ECO:0000250|UniProtKB:Q3URD3}.
uniprot
proteins
mass_dalton
98224
uniprot
proteins
protein_family
SLMAP family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15591093
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
858
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000269|PubMed:15591093}; Single-pass type IV membrane protein {ECO:0000269|PubMed:15591093}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q3URD3}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q14BN4}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q14BN4}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q14BN4}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q14BN4}. Note=Distributed in the transverse tubules and near the junctional sarcoplasmic reticulum. Detected along the Z-lines and M-lines in cardiomyocytes. Membrane-associated (By similarity). Localizes to the centrosomes in a microtubule- dependent manner (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 833..853; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins