Iffo1
entrez
320678
canonical
uniprot
Q8BXL9
canonical
ensembl
ENSMUSG00000038271
resolver
ensp
ENSMUSP00000113088
resolver
ensp
ENSMUSP00000113376
resolver
ensp
ENSMUSP00000262423
resolver
ensp
ENSMUSP00000262424
resolver
ensp
ENSMUSP00000262427
resolver
ensp
ENSMUSP00000262430
resolver
ensp
ENSMUSP00000262431
resolver
genesymbol
Iffo1
resolver
genesymbol_syn
Iffo
resolver
uniprot
Q3TQI1
resolver
uniprot
Q6PFE6
resolver
uniprot
Q8BXS3
resolver
uniprot
Q8C1D6
resolver
uniprot_entry
IFFO1_MOUSE
resolver
uniprot_sec
Q3TQI1
resolver
uniprot_sec
Q6PFE6
resolver
uniprot_sec
Q8BXS3
resolver
uniprot_sec
Q8C1D6
resolver
amino_acid_sequence
MNPLFGPNLFLLQQEQQGLAGPLGDPLGGDHFAGGGDLASAPLASAGPSAYSPPGPGPAPPAAMALRNDLGSNINVLKTLNLRFRCFLAKVHELERRNRLLEKQLQQALEEGKQGRRGLARRDQAVQTGFISPIRPLGLPLSSRPAAVCPPSARVLGSPSRSPAGPLASSAACHTSSSTSTSTAFSSSTRFMPGTIWSFSHARRLGPGLEPTLVQGPGLSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQERVTELQEEAQEADACQEELAMKVEQLKAELVVFKGLMSNNLTELDTKIQEKAMKVDMDICRRIDITAKLCDLAQQRNCEDMIQMFQKKLVPSMGGRKRERKAAVEEDTSLSESDGPRQPEGAEEESTALSINEEMQRMLSQLREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTREKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPPPPPSETEDSDRDVSSDSSMR
uniprot
proteins
function
FUNCTION: Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that will relocalize to the DSB sites in a XRCC4-dependent manner and promote the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606). {ECO:0000269|PubMed:31548606}.
uniprot
proteins
mass_dalton
62415
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
31548606
uniprot
proteins
sequence_length
562
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q0D2I5}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q0D2I5}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q0D2I5}. Nucleus matrix {ECO:0000250|UniProtKB:Q0D2I5}. Note=Mainly soluble, the remaining is localized in the nuclear matrix. Localized at double-strand break (DSB) sites near the lamina and nuclear matrix structures. {ECO:0000250|UniProtKB:Q0D2I5}.
uniprot
proteins