Snap23
entrez
20619
canonical
uniprot
O09044
canonical
ensembl
ENSMUSG00000027287
resolver
ensp
ENSMUSP00000028743
resolver
ensp
ENSMUSP00000106339
resolver
ensp
ENSMUSP00000112138
resolver
ensp
ENSMUSP00000252705
resolver
ensp
ENSMUSP00000252706
resolver
ensp
ENSMUSP00000342528
resolver
ensp
ENSMUSP00000342529
resolver
ensp
ENSMUSP00000355652
resolver
enst
ENSMUST00000028743
resolver
enst
ENSMUST00000110711
resolver
enst
ENSMUST00000116437
resolver
genesymbol
Snap23
resolver
genesymbol_syn
SNAP-23
resolver
genesymbol_syn
Sndt
resolver
uniprot
A2AKH4
resolver
uniprot
F6TX29
resolver
uniprot
O35620
resolver
uniprot
Q9D3L3
resolver
uniprot_entry
A2AKH4_MOUSE
resolver
uniprot_entry
F6TX29_MOUSE
resolver
uniprot_entry
Q9D3L3_MOUSE
resolver
uniprot_entry
SNP23_MOUSE
resolver
uniprot_sec
O35620
resolver
amino_acid_sequence
MDNLSPEEVQLRAHQVTDESLESTRRILGLAIESQDAGIKTITMLDEQGEQLNRIEEGMDQINKDMREAEKTLTELNKCCGLCICPCNRTKNFESGKNYKATWGDGGDNSPSNVVSKQPSRITNGQPQQTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKNMALDMGNEIDAQNQQIQKITEKADTNKNRIDIANTRAKKLIDS
uniprot
proteins
function
FUNCTION: SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (PubMed:38198890). SNAP23 is a t-SNARE (target-SNARE) that resides on target membrane and functions in the fusion of transport vesicles with the plasma membrane in immune cells. In macrophages, regulates the stimulus-dependent vesicular transport of TLR4 from recycling endosomes to the plasma membrane by cooperating with STX11 and thereby plays a critical role in the recognition of microbial components and the induction of innate and adaptive immunity (By similarity). In skeletal muscle satellite cells, SNAP23 cooperates with its cognate SNAREs VAMP4 and STX11 to facilitate CD36 vesicular transport from endosomes to the plasma membrane, an essential step in muscle regeneration (PubMed:38198890). {ECO:0000250|UniProtKB:O00161, ECO:0000269|PubMed:38198890}.
uniprot
proteins
mass_dalton
23261
uniprot
proteins
mutagenesis
MUTAGEN 119; /note="P->A: Inhibits interaction with ZDHHC13 and ZDHHC17.
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type A (BoNT/A, botA) which hydrolyzes the 202-Thr-|-Arg-203 bond; the in vitro reaction is not highly efficient (PubMed:9886085). {ECO:0000269|PubMed:9886085}.; PTM: (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type E (BoNT/E) which hydrolyzes the 185-Arg-|-Ile-186 bond; the in vitro reaction is more efficient than that of BoNT/A (PubMed:9886085). {ECO:0000269|PubMed:9886085}.
uniprot
proteins
protein_family
SNAP-25 family
uniprot
proteins
pubmed
10773458
uniprot
proteins
pubmed
15363411
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26198635
uniprot
proteins
pubmed
38198890
uniprot
proteins
pubmed
9067602
uniprot
proteins
pubmed
9168999
uniprot
proteins
pubmed
9507000
uniprot
proteins
pubmed
9886085
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O00161}; Lipid-anchor {ECO:0000250|UniProtKB:O00161}.
uniprot
proteins