Jmjd7
entrez
433466
canonical
uniprot
P0C872
canonical
ensembl
ENSMUSG00000098789
resolver
ensp
ENSMUSP00000041220
resolver
enst
ENSMUST00000044675
resolver
genesymbol
Jmjd7
resolver
uniprot
A2AP62
resolver
uniprot
Q4QQM1
resolver
uniprot
Q80VV8
resolver
uniprot
Q91W88
resolver
uniprot_entry
JMJD7_MOUSE
resolver
uniprot_sec
A2AP62
resolver
uniprot_sec
Q4QQM1
resolver
uniprot_sec
Q80VV8
resolver
uniprot_sec
Q91W88
resolver
amino_acid_sequence
MAEAALEAVRRALQEFPAAARDLNVPRVVPYLDEPPSPLCFYRDWVCPNRPCIIRNALQHWPALQKWSLSYLRATVGSTEVSVAVTPDGYADAVRGDRFVMPAERRLPISHVLDVLEGRAQHPGVLYVQKQCSNLPTELPQLLSDIESHVPWASESLGKMPDAVNFWLGDASAVTSLHKDHYENLYCVVSGEKHFLLHPPSDRPFIPYNLYTPATYQLTEEGTFRVVDEEAMEKVPWIPLDPLAPDLTQYPSYSQAQALHCTVRAGEMLYLPALWFHHVQQSHGCIAVNFWYDMEYDLKYSYFQLMDTLTRATGLD
uniprot
proteins
ec_number
1.14.11.63
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase (By similarity) (PubMed:28847961). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961). Additionally, may play a role in protein biosynthesis by modifying the translation machinery. Acts as a Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys-21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA) (By similarity). {ECO:0000250|UniProtKB:P0C870, ECO:0000269|PubMed:28847961}.
uniprot
proteins
mass_dalton
35917
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28847961
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P0C870}. Cytoplasm {ECO:0000250|UniProtKB:P0C870}.
uniprot
proteins