Spata18
entrez
289586
canonical
uniprot
Q6AYL6
canonical
ensembl
ENSRNOG00000002120
resolver
ensembl
ENSRNOG00055005260
resolver
ensembl
ENSRNOG00060019903
resolver
ensembl
ENSRNOG00065020512
resolver
ensp
ENSRNOP00000095811
resolver
ensp
ENSRNOP00000101322
resolver
genesymbol
Spata18
resolver
genesymbol_syn
Mieap
resolver
genesymbol_syn
Spetex1
resolver
uniprot
A6JD28
resolver
uniprot
D3ZEU0
resolver
uniprot
Q764P0
resolver
uniprot_entry
MIEAP_RAT
resolver
uniprot_sec
A6JD28
resolver
uniprot_sec
D3ZEU0
resolver
uniprot_sec
Q764P0
resolver
amino_acid_sequence
MAENLKKLAQSESFLSLQDKVCFWANDYQTNSCDQNLNCCIELIEQVAKVQAQLFAILTATAQEGGHNEGVETIKSRLLPLLQTSFSSLGVGKIIQTEIRPIQDFQLRSKNRQSSLDQEQQQSDGDSFIESQPTQVQDDLTESGKNLEGTKNGSAISLLAAEEEINQLKKQLKSLQAQEDARHKTSENRRAEISRTDRRPSGKRNSERPQDVVSNYEKHLKNLKDEIAVLSAEKSGLQASHRQTRSRSPSPGPRGPRGPRGRRRSRSHSRSHSRSHSRSHSHSNSHSNSRSNSPCTTVAKIRSPSPNRSKMSSVARKAALLSRFSDAYSQARLDAQCLLRRCIDRAETVQRIIYIATVEAFHIAKMAFRHFKIRVRKMLTPSHVGSNDFETAVSDYIVCHLDLYDSQSSVNDVIRAMNVNPKISFPPEVDFCLLTDFIQEICCIAFAMQSLEPPLDIAFGADGEVFNEAKYRRSYDSDFTAPLVFYHVWPALMENDCVIMKGEAVTKRGAFWTTVRPVMRCRSRSLSPICPRSRFGISTVSRSRSPSPIRCTFARY
uniprot
proteins
function
FUNCTION: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Binds cardiolipin. May form molecular condensates (non-membrane-bounded organelles) within mitochondria that compartmentalize and promote cardiolipin metabolism. {ECO:0000250|UniProtKB:Q8TC71}.
uniprot
proteins
mass_dalton
62633
uniprot
proteins
protein_family
MIEAP family
uniprot
proteins
pubmed
15236321
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
556
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8TC71}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8TC71}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q8TC71}. Note=Localizes to the cytosol under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress. May form molecular condensates in the mitochondrial matrix. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane. {ECO:0000250|UniProtKB:Q8TC71}.
uniprot
proteins