Slc1a1
entrez
25550
canonical
uniprot
P51907
canonical
ensembl
ENSRNOG00000014816
resolver
ensembl
ENSRNOG00055030650
resolver
ensembl
ENSRNOG00060026771
resolver
ensembl
ENSRNOG00065026368
resolver
ensp
ENSRNOP00000096736
resolver
ensp
ENSRNOP00055043964
resolver
ensp
ENSRNOP00060038549
resolver
ensp
ENSRNOP00065037313
resolver
enst
ENSRNOT00000099702
resolver
enst
ENSRNOT00055053196
resolver
enst
ENSRNOT00060046386
resolver
enst
ENSRNOT00065045510
resolver
genesymbol
Slc1a1
resolver
genesymbol_syn
Eaac1
resolver
genesymbol_syn
Eaat3
resolver
uniprot
O88389
resolver
uniprot
Q63727
resolver
uniprot
Q9JJP8
resolver
uniprot_entry
EAA3_RAT
resolver
uniprot_sec
O88389
resolver
uniprot_sec
Q63727
resolver
uniprot_sec
Q9JJP8
resolver
amino_acid_sequence
MGKPTSSGCDWRRFLRNHWLLLSTVAAVVLGIVVGVLVRGHSELSNLDKFYFAFPGEILMRMLKLVILPLIISSMITGVAALDSNVSGKIGLRAVVYYFSTTVIAVILGIVLVVSIKPGVTQKVNEINRTGKTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPASDPGGNQTEVSVTTAMTTMSENKTKEYKIVGLYSDGINVLGLIIFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMATVLSGLAIHSLVVLPLIYFIVVRKNPFRFALGMAQALLTALMISSSSATLPVTFRCAEEKNHVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNGMDLSIGQIITISITATAASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQVDVSSEVNIVNPFALEPTILDNEDSDTKKSYVNGGFSVDKSDTISFTQTSQF
uniprot
proteins
function
FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:11242046, PubMed:9011753). Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (PubMed:11242046). {ECO:0000250|UniProtKB:P43005, ECO:0000250|UniProtKB:P51906, ECO:0000269|PubMed:11242046}.
uniprot
proteins
mass_dalton
56772
uniprot
proteins
protein_family
Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family
uniprot
proteins
protein_family
SLC1A1 subfamily
uniprot
proteins
pubmed
11242046
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19720795
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8613726
uniprot
proteins
pubmed
8738164
uniprot
proteins
pubmed
8747153
uniprot
proteins
pubmed
8772431
uniprot
proteins
pubmed
9011753
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11242046, ECO:0000269|PubMed:19720795, ECO:0000269|PubMed:9011753}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43003}. Apical cell membrane {ECO:0000250|UniProtKB:P43005}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43003}. Synapse, synaptosome {ECO:0000250|UniProtKB:P51906}. Early endosome membrane {ECO:0000250|UniProtKB:P51906}. Late endosome membrane {ECO:0000250|UniProtKB:P51906}. Recycling endosome membrane {ECO:0000250|UniProtKB:P51906}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..38; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 205..228; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 238..265; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 286..307; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 353..379; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 440..461; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P43003
uniprot
proteins