Dcun1d1
entrez
114893
canonical
uniprot
Q9QZ73
canonical
ensembl
ENSMUSG00000027708
resolver
ensp
ENSMUSP00000103817
resolver
ensp
ENSMUSP00000115420
resolver
ensp
ENSMUSP00000137324
resolver
ensp
ENSMUSP00000143243
resolver
ensp
ENSMUSP00000267815
resolver
enst
ENSMUST00000108182
resolver
enst
ENSMUST00000178098
resolver
enst
ENSMUST00000198389
resolver
genesymbol
Dcun1d1
resolver
genesymbol_syn
Dcun1l1
resolver
genesymbol_syn
Rp42
resolver
genesymbol_syn
SCCRO
resolver
genesymbol_syn
Tes3
resolver
uniprot
J3QPJ4
resolver
uniprot
Q3TMX2
resolver
uniprot
Q3UT23
resolver
uniprot
Q8CDZ7
resolver
uniprot_entry
DCNL1_MOUSE
resolver
uniprot_entry
J3QPJ4_MOUSE
resolver
uniprot_entry
Q3UT23_MOUSE
resolver
uniprot_sec
Q3TMX2
resolver
uniprot_sec
Q8CDZ7
resolver
amino_acid_sequence
MNKLKSSQKDKVRQFMIFTQSSEKTAVSCLSQNDWKLDVATDNFFQNPELYIRESVKGSLDRKKLEQLYTRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQEFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIAYWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSSMIADDMSNYDEEGAWPVLIDDFVEFARPQIAGTKSTTV
uniprot
proteins
function
FUNCTION: Part of an E3 ubiquitin ligase complex for neddylation (By similarity). Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes (PubMed:26792857). Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (By similarity). Also acts as an oncogene facilitating malignant transformation and carcinogenic progression (PubMed:20563250). {ECO:0000250|UniProtKB:Q96GG9, ECO:0000269|PubMed:20563250, ECO:0000269|PubMed:26792857}.
uniprot
proteins
mass_dalton
30097
uniprot
proteins
mutagenesis
MUTAGEN 241; /note="D->N: Loss of neddylation activity towards Cul3."; /evidence="ECO:0000269|PubMed:26792857
uniprot
proteins
post_translational_modification
PTM: Mono- and poly-ubiquitinated by ARIH2 and ARIH1. Monoubiquitination by ARIH2 is mediated by an interaction between autoubiquitinated ARIH2 and the UBA-like domain. The monoubiquitinated form preferentially interacts with non-neddylated cullins and modulates cullin RING ligase (CRL) complex composition and activity. {ECO:0000250|UniProtKB:Q96GG9}.
uniprot
proteins
pubmed
10777668
uniprot
proteins
pubmed
10831844
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20563250
uniprot
proteins
pubmed
26792857
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96GG9}. Cytoplasm {ECO:0000250|UniProtKB:Q96GG9}. Note=The ubiquitinated form is localized in the cytoplasm. {ECO:0000250|UniProtKB:Q96GG9}.
uniprot
proteins