Lpcat3
entrez
362434
canonical
uniprot
Q5FVN0
canonical
ensembl
ENSRNOG00000012269
resolver
ensembl
ENSRNOG00055010100
resolver
ensembl
ENSRNOG00060032395
resolver
ensembl
ENSRNOG00065028897
resolver
ensp
ENSRNOP00000094198
resolver
ensp
ENSRNOP00055013710
resolver
ensp
ENSRNOP00060046369
resolver
ensp
ENSRNOP00065041009
resolver
enst
ENSRNOT00055017051
resolver
enst
ENSRNOT00060056123
resolver
enst
ENSRNOT00065049928
resolver
genesymbol
Lpcat3
resolver
genesymbol_syn
Grcc3f
resolver
genesymbol_syn
Mboat5
resolver
genesymbol_syn
Oact5
resolver
uniprot_entry
MBOA5_RAT
resolver
amino_acid_sequence
MASTADGDVGETLGQMRGLWPGVEDLSLNKLATSLGASEQALRLIFSIFLGYPLALFYRHYLFYKDSYLIHLFHAFSGLSIAYFNFGHQFYHSLLCVVLQFLILRLMGRTITAVFTTLCFQMAYLLAGYYYTATGDYDIKWTMPHCVLTLKLIGLSIDYYDGGKDRNSLSSEQQKYAILGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVKGQLTDVPGKMPNSTIPALKRLSLGLVYLVGYTLLSPHITEDYLLTEDYDTRPFWFRCMYMLIWGKFVLYKYVTCWLVTEGVCILSGLGFNGFEENGTVKWDACANMKVWLFETTPRFTGTIASFNINTNAWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLICFQMEFLIVIVEKQATNLIRDSPALSSLASITALQPFYYLVQQTIHWLFMGYSMTAFCLFTWDKWLKVYRSIYFLGHVFFLSLLFTLPYVYKAMVPRKEKLKKRE
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.23
uniprot
proteins
ec_number
2.3.1.n6
uniprot
proteins
ec_number
2.3.1.n7
uniprot
proteins
function
FUNCTION: Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle. Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (By similarity). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency. Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus. Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Down-regulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins. In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly. In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity). {ECO:0000250|UniProtKB:Q6P1A2, ECO:0000250|UniProtKB:Q91V01}.
uniprot
proteins
mass_dalton
56018
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000250|UniProtKB:Q6P1A2}.
uniprot
proteins
protein_family
Membrane-bound acyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
487
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6P1A2}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..64; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 67..87; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 111..131; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 178..198; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 285..305; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 364..384; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 422..442; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 453..473; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins