Tacr3
entrez
21338
canonical
uniprot
P47937
canonical
ensembl
ENSMUSG00000028172
resolver
ensp
ENSMUSP00000029822
resolver
enst
ENSMUST00000029822
resolver
genesymbol
Tacr3
resolver
genesymbol_syn
Tac3r
resolver
uniprot
Q61968
resolver
uniprot
Q8BL44
resolver
uniprot
Q9JKN0
resolver
uniprot_entry
NK3R_MOUSE
resolver
uniprot_sec
Q61968
resolver
uniprot_sec
Q8BL44
resolver
uniprot_sec
Q9JKN0
resolver
amino_acid_sequence
MASVPTGENWTDGTAGVGSHTGNLSAALGITEWLALQAGNFSSALGLPVTSQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLVNFIYGVHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLYDPSEGDPAKSSRKKRAVPRDPSANGCSHREFKSASTTSSFISSPYTSVDEYS
uniprot
proteins
function
FUNCTION: Receptor for the tachykinin neuromedin-K (neurokinin B), also able to bind and respond to tachynins substance K/neurokinin A and substance P. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. Neuromedin-K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C. Neuromedin-K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP). {ECO:0000250|UniProtKB:P16177}.
uniprot
proteins
mass_dalton
51026
uniprot
proteins
post_translational_modification
PTM: The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
8120392
uniprot
proteins
sequence_length
452
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P29371}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 72..94; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 105..126; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 147..168; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 233..257; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 287..308; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 322..346; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins