Ehmt2
entrez
110147
canonical
uniprot
Q9Z148
canonical
ensembl
ENSMUSG00000013787
resolver
ensp
ENSMUSP00000013931
resolver
ensp
ENSMUSP00000077208
resolver
ensp
ENSMUSP00000094955
resolver
ensp
ENSMUSP00000109667
resolver
enst
ENSMUST00000097342
resolver
genesymbol
Ehmt2
resolver
genesymbol_syn
Bat8
resolver
genesymbol_syn
G9a
resolver
genesymbol_syn
Ng36
resolver
uniprot
A2CG75
resolver
uniprot
A2CG76
resolver
uniprot
Q6PE08
resolver
uniprot
Q8K4R6
resolver
uniprot
Q8K4R7
resolver
uniprot
Q9Z149
resolver
uniprot_entry
A2CG76_MOUSE
resolver
uniprot_entry
EHMT2_MOUSE
resolver
uniprot_sec
A2CG75
resolver
uniprot_sec
Q6PE08
resolver
uniprot_sec
Q8K4R6
resolver
uniprot_sec
Q8K4R7
resolver
uniprot_sec
Q9Z149
resolver
amino_acid_sequence
MRGLPRGRGLMRARGRGRAAPTGGRGRGRGGAHRGRGRPRSLLSLPRAQASWAPQLPAGLTGPPVPCLPSQGEAPAEMGALLLEKEPRGAAERVHSSLGDTPQSEETLPKANPDSLEPAGPSSPASVTVTVGDEGADTPVGAASLIGDEPESLEGDGGRIVLGHATKSFPSSPSKGGACPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAATAGPEPSPATTAAQEGQPKVHRARKTMSKPSNGQPPIPEKRPPEVQHFRMSDDMHLGKVTSDVAKRRKLNSGSLSEDLGSAGGSGDIILEKGEPRPLEEWETVVGDDFSLYYDAYSVDERVDSDSKSEVEALAEQLSEEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELLGCNAAILKRETMRPSSRVALMVLCEAHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGGTPPIGTAAPALPPLAHDAPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPPGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQLGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIDVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAQCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAVRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRSCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLPDLSSLPPINT
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.367
uniprot
proteins
function
FUNCTION: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones (PubMed:11316813, PubMed:12130538, PubMed:15774718, PubMed:18818694). Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication (PubMed:22387026). Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. Also able to mono- and dimethylate histone H1-4 at 'Lys-26' (H1.4K26me1 and H1.4K26me2, respectively). In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself (By similarity). {ECO:0000250|UniProtKB:Q96KQ7, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:12130538, ECO:0000269|PubMed:15774718, ECO:0000269|PubMed:18818694, ECO:0000269|PubMed:22387026}.
uniprot
proteins
mass_dalton
138039
uniprot
proteins
mutagenesis
MUTAGEN 1120; /note="Y->V: In GM7; defective in methyltransferase activity without affecting DNA methylation; when associated with F-1207."; /evidence="ECO:0000269|PubMed:18818694"; MUTAGEN 1162; /note="R->H: Strongly reduces histone methyltransferase activity."; /evidence="ECO:0000269|PubMed:11316813"; MUTAGEN 1165..1168; /note="Missing: Abolishes histone methyltransferase activity and subsequent repression. In GM3; does not form heterodimer with EHMT1 and is defective in mediating both H3K9me and DNA methylation."; /evidence="ECO:0000269|PubMed:12130538, ECO:0000269|PubMed:18818694"; MUTAGEN 1165..1166; /note="NH->LE: In GM6; does not form heterodimer with EHMT1 and is defective in mediating H3K9me."; /evidence="ECO:0000269|PubMed:18818694"; MUTAGEN 1168; /note="C->A: In GM4; defective in methyltransferase activity without affecting DNA methylation."; /evidence="ECO:0000269|PubMed:18818694"; MUTAGEN 1207; /note="Y->F: In GM7; defective in methyltransferase activity without affecting DNA methylation; when associated with V-1120."; /evidence="ECO:0000269|PubMed:18818694
uniprot
proteins
post_translational_modification
PTM: Methylated at Lys-239; automethylated. {ECO:0000250}.
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
protein_family
Suvar3-9 subfamily
uniprot
proteins
pubmed
11316813
uniprot
proteins
pubmed
11707778
uniprot
proteins
pubmed
12130538
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15774718
uniprot
proteins
pubmed
16702210
uniprot
proteins
pubmed
18818694
uniprot
proteins
pubmed
19056828
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22387026
uniprot
proteins
pubmed
22629437
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
27932493
uniprot
proteins
pubmed
28250819
uniprot
proteins
pubmed
37405986
uniprot
proteins
sequence_length
1263
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96KQ7}. Chromosome {ECO:0000250|UniProtKB:Q96KQ7}. Note=Almost excluded form nucleoli. Associates with euchromatic regions (By similarity). Does not associate with heterochromatin (By similarity). {ECO:0000250|UniProtKB:Q96KQ7}.
uniprot
proteins