Rit1
entrez
19769
canonical
uniprot
P70426
canonical
ensembl
ENSMUSG00000028057
resolver
ensp
ENSMUSP00000029692
resolver
ensp
ENSMUSP00000130464
resolver
ensp
ENSMUSP00000313259
resolver
ensp
ENSMUSP00000313277
resolver
ensp
ENSMUSP00000313281
resolver
enst
ENSMUST00000029692
resolver
enst
ENSMUST00000172252
resolver
genesymbol
Rit1
resolver
genesymbol_syn
Rit
resolver
uniprot
E9Q672
resolver
uniprot_entry
E9Q672_MOUSE
resolver
uniprot_entry
RIT1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Alternates between an inactive form bound to GDP and an active form bound to GTP (By similarity). {ECO:0000250|UniProtKB:Q92963}.
uniprot
proteins
amino_acid_sequence
MESGARPIGSSCSSPAALSREYKLVMLGAGGVGKSAMTMQFISHRFPEDHDPTIEDAYKIRIRIDDEPANLDILDTAGQAEFTAMRDQYMRAGEGFIICYSITDRRSFHEVREFKQLIYRVRRTDDTPVVLVGNKSDLKQLRQVSKEEGLSLAREFSCPFFETSAAYRYYIDDVFHALVREIRKKEKELVLAMEKKAKPKNSVWKRLKSPFRRKKDSVT
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Plays a crucial role in coupling nerve growth factor (NGF) stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation (By similarity). Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation (By similarity). Recognized by LZTR1, which mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity). {ECO:0000250|UniProtKB:Q92963}.
uniprot
proteins
mass_dalton
25169
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10869344
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8824319
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane.
uniprot
proteins