Mknk1
entrez
500526
canonical
uniprot
Q4G050
canonical
ensembl
ENSRNOG00000010381
resolver
ensembl
ENSRNOG00055031735
resolver
ensembl
ENSRNOG00060027422
resolver
ensembl
ENSRNOG00065015956
resolver
ensp
ENSRNOP00000061535
resolver
ensp
ENSRNOP00000072679
resolver
ensp
ENSRNOP00000102287
resolver
ensp
ENSRNOP00000112550
resolver
ensp
ENSRNOP00055045399
resolver
ensp
ENSRNOP00060039586
resolver
ensp
ENSRNOP00065020796
resolver
enst
ENSRNOT00000067655
resolver
enst
ENSRNOT00000121912
resolver
enst
ENSRNOT00055054940
resolver
enst
ENSRNOT00060047575
resolver
enst
ENSRNOT00065026514
resolver
genesymbol
Mknk1
resolver
genesymbol_syn
Mnk1
resolver
uniprot
A0A8L2QVH8
resolver
uniprot
A0ABK0MAZ0
resolver
uniprot_entry
A0A8L2QVH8_RAT
resolver
uniprot_entry
A0ABK0MAZ0_RAT
resolver
uniprot_entry
MKNK1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MGSSEPLPIVDSDKRRKKKRKTRATDSLPGKFEDVYQLTSELLGEGAYAKVQGAVSLQSGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNRNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKRKHFNELEASRVVRDVATALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGVKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFRDEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRMCQNKLFESIQEGKYEFPDKDWAHISTEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPERGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEHEALAEGLCSMKLSPPSKSRLARRRALAHAGREANSCSTPAGL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
46214
uniprot
proteins
post_translational_modification
PTM: Dual phosphorylation of Thr-197 and Thr-202 activates the kinase. Phosphorylation of Thr-332 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
413
uniprot
proteins