DNAJC24
entrez
120526
canonical
uniprot
Q6P3W2
canonical
ensembl
ENSG00000170946
resolver
ensp
ENSP00000417548
resolver
genesymbol
DNAJC24
resolver
genesymbol_syn
DPH4
resolver
genesymbol_syn
ZCSL3
resolver
hgnc
HGNC:26979
resolver
uniprot
A8K0V0
resolver
uniprot
B1ALC1
resolver
uniprot
I6L9B4
resolver
uniprot_entry
DJC24_HUMAN
resolver
uniprot_sec
A8K0V0
resolver
uniprot_sec
B1ALC1
resolver
uniprot_sec
I6L9B4
resolver
amino_acid_sequence
MMAVEQMPKKDWYSILGADPSANISDLKQKYQKLILMYHPDKQSTDVPAGTVEECVQKFIEIDQAWKILGNEETKREYDLQRCEDDLRNVGPVDAQVYLEEMSWNEGDHSFYLSCRCGGKYSVSKDEAEEVSLISCDTCSLIIELLHYN
uniprot
proteins
function
FUNCTION: Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000269|PubMed:22367199, ECO:0000269|PubMed:22509046}.
uniprot
proteins
mass_dalton
17139
uniprot
proteins
mutagenesis
MUTAGEN 139; /note="C->S: Loss of iron-binding."; /evidence="ECO:0000269|PubMed:22367199
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis.
uniprot
proteins
protein_family
DPH4 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
22367199
uniprot
proteins
pubmed
22509046
uniprot
proteins
sequence_length
149
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
uniprot
proteins