Lrrc8e
entrez
304203
canonical
uniprot
Q3KRC6
canonical
ensembl
ENSRNOG00000028460
resolver
ensp
ENSRNOP00000037487
resolver
enst
ENSRNOT00000035142
resolver
genesymbol
Lrrc8e
resolver
uniprot_entry
LRC8E_RAT
resolver
amino_acid_sequence
MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPSHESRENSSEAPCQQLLPQGISEQIGGLRELSGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENHKGPAAGRATVTTVTTVGTGTGKVGEGEKEKVLIEPEKVVTEPPAVTLLDKKEGEQAKALFEKVKKFRVHVEEGDILYSMYIRQTVLKVCKFFAILVYNLVYVEKISFLVACRVETSEITGYASFCCNHTKAHLFSKLAFCYISFVCVYGITCLYTLYWLFHRPLKEYSFRSVREETGMNDIPDVRNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPDKLRQKLQRNARGRLELSLCMLPGLPDTVFELSEVEALRLEAICDISFPPGLSQLVNLQELSLLHSPARLPFSSQIFLRDRLKVICVKFEELREVPLWVFGLRGLEELHLEGLFPPEMARGATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLLALNSLKKLAVLRELELVACGLERIPHAIFSLGALQELDLKDNHLRSIEEILSFQHCRKLVILRLWHNQIAYVPEHVRKLRSLEQLYLSHNKLETLPAQLGQCFGLRLLDVSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCHKLRTLLLGYNHLTQFSPHVAALQALSRLELKGNRLEALPEELGDCKGLKKSGLLVEDTLYEGLPAEVREKMEEE
uniprot
proteins
function
FUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:28833202). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:28833202). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (By similarity). {ECO:0000250|UniProtKB:Q6NSJ5, ECO:0000269|PubMed:28833202}.
uniprot
proteins
mass_dalton
90445
uniprot
proteins
protein_family
LRRC8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28833202
uniprot
proteins
sequence_length
795
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28833202}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6NSJ5}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6NSJ5}. Lysosome membrane {ECO:0000250|UniProtKB:Q6NSJ5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6NSJ5}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6NSJ5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6NSJ5}. Note=In the absence of LRRC8A, resides primarily in the endoplasmic reticulum. Requires LRRC8A for localization at the cell membrane or lysosome membrane. {ECO:0000250|UniProtKB:Q6NSJ5}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 313..333; /note="Helical; Name=4"; /evidence="ECO:0000255
uniprot
proteins