Rab27b
entrez
84590
canonical
uniprot
Q99P74
canonical
ensembl
ENSRNOG00000012176
resolver
ensembl
ENSRNOG00055009273
resolver
ensembl
ENSRNOG00060010618
resolver
ensembl
ENSRNOG00065024802
resolver
ensp
ENSRNOP00000016369
resolver
ensp
ENSRNOP00000095120
resolver
ensp
ENSRNOP00055012596
resolver
ensp
ENSRNOP00060013984
resolver
ensp
ENSRNOP00065034847
resolver
enst
ENSRNOT00000016369
resolver
enst
ENSRNOT00000106463
resolver
enst
ENSRNOT00055015683
resolver
enst
ENSRNOT00060017979
resolver
enst
ENSRNOT00065042585
resolver
genesymbol
Rab27b
resolver
uniprot
A0A8L2Q7R9
resolver
uniprot_entry
A0A8L2Q7R9_RAT
resolver
uniprot_entry
RB27B_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including DENND10, which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:O00194}.
uniprot
proteins
amino_acid_sequence
MTDGDYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYDTQGADGSSGKAFKVHLQLWDTAGQERFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCENPDIVLIGNKADLLDQREVNERQARELAEKYGIPYFETSAATGQNVEKSVETLLDLIMKRMEKCVEKTQVPDTVNGVNSGKVDGEKPAEKKCAC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB27B regulates homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity). {ECO:0000250|UniProtKB:O00194, ECO:0000250|UniProtKB:Q8HZJ5, ECO:0000269|PubMed:21775604}.
uniprot
proteins
mass_dalton
24620
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
21775604
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:O00194}; Lipid-anchor {ECO:0000250|UniProtKB:O00194}. Late endosome {ECO:0000250|UniProtKB:O00194}.
uniprot
proteins