Q8VD52
uniprot
Q8VD52
canonical
amino_acid_sequence
MARCERLRGAALRDVLGQAQGVLFDCDGVLWNGERIVPGAPELLQRLAQAGKATLFVSNNSRRARPELALRFARLGFTGLRAEELFSSAVCAARLLRQRLPGPPDAPGAVFVLGGEGLRAELRAAGLRLAGDPGDDPRVRAVLVGYDEHFSFAKLTEACAHLRDPDCLLVATDRDPWHPLTDGSRTPGTGSLAAAVETASGRQALVVGKPSPYMFQCITEDFSVDPARMLMVGDRLETDILFGHRCGMTTVLTLTGVSSLEEAQAYLAAGQHDLVPHYYVESIADLMEGLGGLSPPPQFPDPVDGGYRP
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.74
uniprot
proteins
function
FUNCTION: Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine. {ECO:0000250|UniProtKB:Q96GD0}.
uniprot
proteins
mass_dalton
33115
uniprot
proteins
protein_family
HAD-like hydrolase superfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q96GD0}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q96GD0}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q96GD0}; Peripheral membrane protein {ECO:0000250, ECO:0000250|UniProtKB:Q96GD0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q96GD0}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:Q96GD0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96GD0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q96GD0}. Cell membrane {ECO:0000250|UniProtKB:Q96GD0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96GD0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q96GD0}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody. {ECO:0000250|UniProtKB:Q96GD0}.
uniprot
proteins