H2az1
entrez
58940
canonical
uniprot
P0C0S7
canonical
ensembl
ENSRNOG00000010306
resolver
ensembl
ENSRNOG00055010753
resolver
ensembl
ENSRNOG00060023034
resolver
ensembl
ENSRNOG00065025820
resolver
ensp
ENSRNOP00000013919
resolver
ensp
ENSRNOP00055014601
resolver
ensp
ENSRNOP00060032974
resolver
ensp
ENSRNOP00065036489
resolver
enst
ENSRNOT00055018174
resolver
enst
ENSRNOT00060039905
resolver
enst
ENSRNOT00065044525
resolver
genesymbol
H2az1
resolver
genesymbol_syn
H2afz
resolver
genesymbol_syn
H2az
resolver
uniprot
P17317
resolver
uniprot
Q5U5H6
resolver
uniprot_entry
H2AZ_RAT
resolver
uniprot_sec
P17317
resolver
uniprot_sec
Q5U5H6
resolver
amino_acid_sequence
MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV
uniprot
proteins
function
FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). {ECO:0000250|UniProtKB:P0C0S5, ECO:0000250|UniProtKB:P0C0S6}.
uniprot
proteins
mass_dalton
13553
uniprot
proteins
post_translational_modification
PTM: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression. {ECO:0000250|UniProtKB:P0C0S5}.; PTM: Acetylated on Lys-5, Lys-8, Lys-12 and Lys-14 by KAT2A; KAT2A is recruited by the XPC complex in absence of DNA damage (By similarity). Acetylated on Lys-5, Lys-8 and Lys-12 during interphase; acetylation disappears at mitosis (By similarity). Acetylation by the NuA4 histone acetyltransferase complex is required for hematopoietic stem cell maintenance (By similarity). {ECO:0000250|UniProtKB:P0C0S5, ECO:0000250|UniProtKB:P0C0S6}.; PTM: Not phosphorylated. {ECO:0000250|UniProtKB:P0C0S4}.; PTM: Monomethylated on Lys-5 and Lys-8 by SETD6. SETD6 predominantly methylates Lys-8, lys-5 being a possible secondary site. {ECO:0000250|UniProtKB:P0C0S5}.; PTM: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. {ECO:0000250|UniProtKB:P0C0S5}.
uniprot
proteins
protein_family
Histone H2A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19343714
uniprot
proteins
pubmed
3344202
uniprot
proteins
sequence_length
128
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome.
uniprot
proteins