Eif2b4
entrez
13667
canonical
uniprot
Q61749
canonical
ensembl
ENSMUSG00000029145
resolver
ensp
ENSMUSP00000076875
resolver
ensp
ENSMUSP00000110250
resolver
ensp
ENSMUSP00000130880
resolver
genesymbol
Eif2b4
resolver
genesymbol_syn
Eif2b
resolver
genesymbol_syn
Eif2bd
resolver
genesymbol_syn
Jgr1a
resolver
uniprot
Q3TYW7
resolver
uniprot
Q61748
resolver
uniprot
Q8VC35
resolver
uniprot_entry
EI2BD_MOUSE
resolver
uniprot_sec
Q3TYW7
resolver
uniprot_sec
Q61748
resolver
uniprot_sec
Q8VC35
resolver
activity_regulation
ACTIVITY REGULATION: Activated by the chemical integrated stress response (ISR) inhibitor ISRIB which stimulates guanine nucleotide exchange factor activity for both phosphorylated and unphosphorylated eIF2. {ECO:0000250|UniProtKB:Q9UI10}.
uniprot
proteins
amino_acid_sequence
MAAVAVAVREESRSEMKTELSPRPGAAGRELTQEEKLQLRKEKKQQKKKRKEEKGADQEIGSAVSAAQRQDPIRELPGPGSQLGGTAGEKLPAGRSKAELRAERRAKQEAERALKQARKGEQGGVPPQACPSTAGETTSGVKRVPEHTPADDPTLLRRLLRKPDRQQVPTRKDYGSKVSLFSHLPQYSRQSSLTQYMSIPSSVIHPAMVRLGLQYSQGLISGSNARCIALLHALQQVIQDYTTPPSEELSRDLVNKLKPYISFLTQCRPMSASMCNAIKFLTKEVTGMSSSKREEEAKSELREALDRYVQEKIVLAAQAISRFASTKISDGDVILVYGCSSLVSRILQEARVEGRRFRVVVVDSRPRLEGRHMLHSLVRAGVPTSYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGDQVALANWQSHPSLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ
uniprot
proteins
function
FUNCTION: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed. {ECO:0000250|UniProtKB:Q9UI10}.
uniprot
proteins
mass_dalton
57624
uniprot
proteins
protein_family
EIF-2B alpha/beta/delta subunits family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7982969
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09924}.
uniprot
proteins