HAUS1
entrez
115106
canonical
uniprot
Q96CS2
canonical
ensembl
ENSG00000152240
resolver
ensp
ENSP00000282058
resolver
genesymbol
HAUS1
resolver
genesymbol_syn
CCDC5
resolver
genesymbol_syn
HEIC
resolver
hgnc
HGNC:25174
resolver
uniprot
B2RDM7
resolver
uniprot
Q8N837
resolver
uniprot_entry
HAUS1_HUMAN
resolver
uniprot_sec
B2RDM7
resolver
uniprot_sec
Q8N837
resolver
amino_acid_sequence
MEPQEERETQVAAWLKKIFGDHPIPQYEVNPRTTEILHHLSERNRVRDRDVYLVIEDLKQKASEYESEAKYLQDLLMESVNFSPANLSSTGSRYLNALVDSAVALETKDTSLASFIPAVNDLTSDLFRTKSKSEEIKIELEKLEKNLTATLVLEKCLQEDVKKAELHLSTERAKVDNRRQNMDFLKAKSEEFRFGIKAAEEQLSARGMDASLSHQSLVALSEKLARLKQQTIPLKKKLESYLDLMPNPSLAQVKIEEAKRELDSIEAELTRRVDMMEL
uniprot
proteins
function
FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:15082789, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.
uniprot
proteins
mass_dalton
31863
uniprot
proteins
protein_family
HAUS1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15082789
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19369198
uniprot
proteins
pubmed
19427217
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30723163
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15082789, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000305|PubMed:19369198}. Note=Localizes with the spindle poles in mitotic cells. In metaphase, localizes to the mitotic asters and is highly punctate on the microtubule array. During later stages of mitosis, remains on the spindle but is not present at the interzone, and is finally observed at the microtubule bundles proximal to the midbody, clearly excluded from the midbody. In contrast, does not colocalize with the tubulin cytoskeleton in interphase cells. In interphase, localized at the centrosome and diffusely in the cytoplasm. Localizes to mitotic spindle microtubules. {ECO:0000269|PubMed:15082789, ECO:0000269|PubMed:30723163}.
uniprot
proteins