TRIM41
entrez
90933
canonical
uniprot
Q8WV44
canonical
ensembl
ENSG00000146063
resolver
ensp
ENSP00000320869
resolver
ensp
ENSP00000336749
resolver
genesymbol
TRIM41
resolver
genesymbol_syn
RINCK
resolver
hgnc
HGNC:19013
resolver
uniprot
B3KNJ6
resolver
uniprot
D3DWR9
resolver
uniprot
Q5BKT0
resolver
uniprot
Q7L484
resolver
uniprot
Q96Q10
resolver
uniprot
Q9BSL8
resolver
uniprot_entry
TRI41_HUMAN
resolver
uniprot_sec
B3KNJ6
resolver
uniprot_sec
D3DWR9
resolver
uniprot_sec
Q5BKT0
resolver
uniprot_sec
Q7L484
resolver
uniprot_sec
Q96Q10
resolver
uniprot_sec
Q9BSL8
resolver
amino_acid_sequence
MAAVAMTPNPVQTLQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLWGGEDEEDRDELDREEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRSSWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALKLFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCVLGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRRRLHLPQQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNAETLAHVHTFSAAFLGERVFPFFRVLSKGTRIKLCP
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ligase that plays essential roles in innate antiviral response (PubMed:28169297, PubMed:29760876, PubMed:29899090, PubMed:31979016). Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (PubMed:28169297, PubMed:29899090, PubMed:31979016). Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS (PubMed:29760876). Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (By similarity). Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (PubMed:17893151, PubMed:33378676). {ECO:0000250|UniProtKB:Q5NCC3, ECO:0000269|PubMed:17893151, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:29760876, ECO:0000269|PubMed:29899090, ECO:0000269|PubMed:31979016, ECO:0000269|PubMed:33378676}.
uniprot
proteins
mass_dalton
71670
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="C->A: Abolishes E3 ligase activity."; /evidence="ECO:0000269|PubMed:17893151
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:29760876, ECO:0000269|PubMed:29899090, ECO:0000269|PubMed:31979016}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000269|PubMed:17893151}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11549288
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16022281
uniprot
proteins
pubmed
17893151
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
27812135
uniprot
proteins
pubmed
28169297
uniprot
proteins
pubmed
29760876
uniprot
proteins
pubmed
29899090
uniprot
proteins
pubmed
31979016
uniprot
proteins
pubmed
33378676
uniprot
proteins
sequence_length
630
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16022281, ECO:0000269|PubMed:29899090, ECO:0000269|PubMed:31979016}. Nucleus {ECO:0000269|PubMed:16022281, ECO:0000269|PubMed:29899090, ECO:0000269|PubMed:31979016}.
uniprot
proteins