Azin1
entrez
54375
canonical
uniprot
O35484
canonical
ensembl
ENSMUSG00000037458
resolver
ensp
ENSMUSP00000065544
resolver
ensp
ENSMUSP00000105958
resolver
ensp
ENSMUSP00000324060
resolver
ensp
ENSMUSP00000324061
resolver
ensp
ENSMUSP00000324062
resolver
enst
ENSMUST00000065308
resolver
enst
ENSMUST00000110329
resolver
genesymbol
Azin1
resolver
genesymbol_syn
Oazi
resolver
genesymbol_syn
Oazin
resolver
uniprot
Q542G5
resolver
uniprot
Q8C2R8
resolver
uniprot
Q8K1E5
resolver
uniprot_entry
AZIN1_MOUSE
resolver
uniprot_sec
Q542G5
resolver
uniprot_sec
Q8C2R8
resolver
uniprot_sec
Q8K1E5
resolver
amino_acid_sequence
MKGFIDDANYSVGLLDEGTNLGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQTVVAQIKPFYTVKCNSTPAVLEILAALGTGFACSSKNEMALVQELGVSPENIIFTSPCKQVSQIKYAAKVGVNIMTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEDGNMKFGTTLKNCRHLLECAKELDVQIIGVKFHVSSACKEYQVYVHALSDARCVFDMAGEFGFTMNMLDIGGGFTGTEIQLEEVNHVISPLLDIYFPEGSGIQIISEPGSYYVSSAFTLAVNIIAKKVVENDKFSSGVEKNGSDEPAFVYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYFMMSFSDWYEMQDAGITSDAMMKNFFFAPSCIQLSQEDSFSTEA
uniprot
proteins
function
FUNCTION: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:16916800, PubMed:18062773, PubMed:18508777). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:10698696, PubMed:18062773, PubMed:18369191). {ECO:0000269|PubMed:10698696, ECO:0000269|PubMed:16916800, ECO:0000269|PubMed:18062773, ECO:0000269|PubMed:18369191, ECO:0000269|PubMed:18508777}.
uniprot
proteins
mass_dalton
49549
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1. {ECO:0000269|PubMed:18062773}.
uniprot
proteins
protein_family
ODC antizyme inhibitor subfamily
uniprot
proteins
protein_family
Orn/Lys/Arg decarboxylase class-II family
uniprot
proteins
pubmed
10698696
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16916800
uniprot
proteins
pubmed
18062773
uniprot
proteins
pubmed
18369191
uniprot
proteins
pubmed
18508777
uniprot
proteins
pubmed
18973822
uniprot
proteins
pubmed
19449338
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19449338}.
uniprot
proteins