TOMM5
entrez
401505
canonical
uniprot
Q8N4H5
canonical
ensembl
ENSG00000175768
resolver
ensp
ENSP00000313584
resolver
ensp
ENSP00000367004
resolver
ensp
ENSP00000438204
resolver
genesymbol
TOMM5
resolver
genesymbol_syn
C9orf105
resolver
genesymbol_syn
TOM5
resolver
hgnc
HGNC:31369
resolver
uniprot
B2DG07
resolver
uniprot
F6S928
resolver
uniprot
Q5JRT7
resolver
uniprot_entry
TOM5_HUMAN
resolver
uniprot_sec
B2DG07
resolver
uniprot_sec
F6S928
resolver
uniprot_sec
Q5JRT7
resolver
amino_acid_sequence
MFRIEGLAPKLDPEEMKRKMREDVISSIRNFLIYVALLRVTPFILKKLDSI
uniprot
proteins
function
FUNCTION: Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (PubMed:40080546). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (PubMed:40080546). {ECO:0000269|PubMed:40080546}.
uniprot
proteins
mass_dalton
6035
uniprot
proteins
protein_family
Tom5 family
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18331822
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
40080546
uniprot
proteins
sequence_length
51
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18331822}; Single-pass membrane protein {ECO:0000269|PubMed:18331822, ECO:0000269|PubMed:40080546}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..48; /note="Helical"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ
uniprot
proteins