EHD3
entrez
30845
canonical
uniprot
Q9NZN3
canonical
ensembl
ENSG00000013016
resolver
ensp
ENSP00000327116
resolver
genesymbol
EHD3
resolver
genesymbol_syn
EHD2
resolver
genesymbol_syn
PAST3
resolver
hgnc
HGNC:3244
resolver
uniprot
B4DFR5
resolver
uniprot
D6W574
resolver
uniprot
Q8N514
resolver
uniprot
Q9NZB3
resolver
uniprot_entry
EHD3_HUMAN
resolver
uniprot_sec
B4DFR5
resolver
uniprot_sec
D6W574
resolver
uniprot_sec
Q8N514
resolver
uniprot_sec
Q9NZB3
resolver
amino_acid_sequence
MFSWLGTDDRRRKDPEVFQTVSEGLKKLYKSKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMQGDMEGIIPGNALVVDPKKPFRKLNAFGNAFLNRFVCAQLPNPVLESISVIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVYGALMWSLGKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPSVFGKDNKKKELVNNLAEIYGRIEREHQISPGDFPNLKRMQDQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEESQRPIQMVKGGAFEGTLHGPFGHGYGEGAGEGIDDAEWVVARDKPMYDEIFYTLSPVDGKITGANAKKEMVRSKLPNSVLGKIWKLADIDKDGMLDDDEFALANHLIKVKLEGHELPNELPAHLLPPSKRKVAE
uniprot
proteins
function
FUNCTION: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250). {ECO:0000250|UniProtKB:Q9QXY6, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:19139087, ECO:0000269|PubMed:21791287, ECO:0000269|PubMed:23781025, ECO:0000269|PubMed:24019528, ECO:0000269|PubMed:25686250, ECO:0000305|PubMed:20489164}.
uniprot
proteins
mass_dalton
60887
uniprot
proteins
mutagenesis
MUTAGEN 65; /note="G->R: Abolishes ATP-binding and localizes to cytoplasm."; /evidence="ECO:0000269|PubMed:16251358"; MUTAGEN 203; /note="V->P: Greatly reduces oligomerization and interaction with RAB11FIP2."; /evidence="ECO:0000269|PubMed:16251358"; MUTAGEN 315; /note="K->R: Abolishes sumoylation and localization to tubular structures of the ERC, impairs fast recycling activity from the ERC, no effect on homooligomerization; when associated with R-511."; /evidence="ECO:0000269|PubMed:26226295"; MUTAGEN 485; /note="W->A: Abolishes interaction with RAB11FIP2."; /evidence="ECO:0000269|PubMed:16251358"; MUTAGEN 511; /note="K->R: Abolishes sumoylation localization to tubular structures of the ERC, impairs fast recycling activity from the ERC, no effect on homooligomerization;; when associated with R-315."; /evidence="ECO:0000269|PubMed:26226295
uniprot
proteins
protein_family
Dynamin/Fzo/YdjA family
uniprot
proteins
protein_family
EHD subfamily
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
10673336
uniprot
proteins
pubmed
12121420
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16251358
uniprot
proteins
pubmed
17233914
uniprot
proteins
pubmed
18331452
uniprot
proteins
pubmed
19139087
uniprot
proteins
pubmed
19864458
uniprot
proteins
pubmed
20489164
uniprot
proteins
pubmed
21791287
uniprot
proteins
pubmed
23754701
uniprot
proteins
pubmed
23781025
uniprot
proteins
pubmed
24019528
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25686250
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26226295
uniprot
proteins
sequence_length
535
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:17233914}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:17233914}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, cilium membrane {ECO:0000269|PubMed:25686250}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Localizes to the ciliary pocket from where the cilium protrudes (PubMed:25686250). Colocalizes with RAB8A and MYO5B to a cytoplasmic tubular network devoid of RAB11A (By similarity). Colocalizes with ANK2 in myocyte perinuclear region (PubMed:20489164). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippocampal mossy fiber terminals (By similarity). {ECO:0000250|UniProtKB:Q9QXY6, ECO:0000269|PubMed:20489164, ECO:0000269|PubMed:25686250}.
uniprot
proteins