NR1C2
entrez
5467
canonical
uniprot
Q03181
canonical
ensembl
ENSG00000112033
resolver
ensp
ENSP00000310928
resolver
ensp
ENSP00000353916
resolver
ensp
ENSP00000413314
resolver
ensp
ENSP00000414372
resolver
ensp
ENSP00000545393
resolver
ensp
ENSP00000545394
resolver
ensp
ENSP00000545396
resolver
ensp
ENSP00000545397
resolver
ensp
ENSP00000545398
resolver
ensp
ENSP00000545399
resolver
ensp
ENSP00000545400
resolver
ensp
ENSP00000545401
resolver
ensp
ENSP00000545402
resolver
ensp
ENSP00000545403
resolver
ensp
ENSP00000545405
resolver
ensp
ENSP00000545408
resolver
ensp
ENSP00000545410
resolver
ensp
ENSP00000545412
resolver
ensp
ENSP00000620150
resolver
ensp
ENSP00000620153
resolver
ensp
ENSP00000683770
resolver
ensp
ENSP00000789469
resolver
ensp
ENSP00000789470
resolver
ensp
ENSP00000789471
resolver
genesymbol
NR1C2
resolver
genesymbol
PPARD
resolver
genesymbol_syn
NR1C2
resolver
genesymbol_syn
PPARB
resolver
genesymbol_syn
PPARD
resolver
hgnc
HGNC:9235
resolver
uniprot
A8K6J6
resolver
uniprot
B4E3V3
resolver
uniprot
B6ZGS1
resolver
uniprot
B7Z3W1
resolver
uniprot
E9PE18
resolver
uniprot
F1D8S7
resolver
uniprot
Q5D1P0
resolver
uniprot
Q7Z5K0
resolver
uniprot
Q9BUD4
resolver
uniprot_entry
F1D8S7_HUMAN
resolver
uniprot_entry
PPARD_HUMAN
resolver
uniprot_sec
A8K6J6
resolver
uniprot_sec
B4E3V3
resolver
uniprot_sec
B6ZGS1
resolver
uniprot_sec
B7Z3W1
resolver
uniprot_sec
E9PE18
resolver
uniprot_sec
Q5D1P0
resolver
uniprot_sec
Q7Z5K0
resolver
uniprot_sec
Q9BUD4
resolver
amino_acid_sequence
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
uniprot
proteins
function
FUNCTION: Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues (PubMed:35675826). Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. {ECO:0000269|PubMed:1333051, ECO:0000269|PubMed:15604518, ECO:0000269|PubMed:35675826}.
uniprot
proteins
mass_dalton
49903
uniprot
proteins
post_translational_modification
PTM: 'Lys-48'-linked polyubiquitinated; leading to proteasomal degradation (PubMed:35675826). Deubiquitinated and stabilized by OTUD3 (PubMed:35675826). {ECO:0000269|PubMed:35675826}.
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10198642
uniprot
proteins
pubmed
10809235
uniprot
proteins
pubmed
10851270
uniprot
proteins
pubmed
1333051
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15604518
uniprot
proteins
pubmed
16387648
uniprot
proteins
pubmed
16405912
uniprot
proteins
pubmed
16931011
uniprot
proteins
pubmed
17560785
uniprot
proteins
pubmed
18619963
uniprot
proteins
pubmed
18722772
uniprot
proteins
pubmed
19116277
uniprot
proteins
pubmed
19464171
uniprot
proteins
pubmed
19622862
uniprot
proteins
pubmed
35675826
uniprot
proteins
sequence_length
441
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35675826}.
uniprot
proteins