MDFI
entrez
4188
canonical
uniprot
Q99750
canonical
ensembl
ENSG00000112559
resolver
ensp
ENSP00000230321
resolver
ensp
ENSP00000362141
resolver
ensp
ENSP00000362142
resolver
ensp
ENSP00000393881
resolver
ensp
ENSP00000579843
resolver
ensp
ENSP00000579844
resolver
ensp
ENSP00000598682
resolver
ensp
ENSP00000598683
resolver
ensp
ENSP00000598685
resolver
ensp
ENSP00000598686
resolver
enst
ENST00000230321
resolver
enst
ENST00000373050
resolver
enst
ENST00000373051
resolver
enst
ENST00000909784
resolver
enst
ENST00000909785
resolver
enst
ENST00000928623
resolver
enst
ENST00000928624
resolver
enst
ENST00000928626
resolver
enst
ENST00000928627
resolver
genesymbol
MDFI
resolver
hgnc
HGNC:6967
resolver
uniprot
B1AKB6
resolver
uniprot_entry
B1AKB6_HUMAN
resolver
uniprot_entry
MDFI_HUMAN
resolver
amino_acid_sequence
MYQVSGQRPSGCDAPYGAPSAAPGPAQTLSLLPGLEVVTGSTHPAEAAPEEGSLEEAATPMPQGNGPGIPQGLDSTDLDVPTEAVTCQPQGNPLGCTPLLPNDSGHPSELGGTRRAGNGALGGPKAHRKLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLCNIVLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECCGLCFSS
uniprot
proteins
function
FUNCTION: Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis (By similarity). Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals (By similarity). Can also interfere with the DNA-binding activity of Myod family members (By similarity). Plays an important role in trophoblast and chondrogenic differentiation (By similarity). Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA (By similarity). Binds to the axin complex, resulting in an increase in the level of free beta-catenin (By similarity). Affects axin regulation of the WNT and JNK signaling pathways (By similarity). Regulates the activity of mechanosensitive Piezo channel (PubMed:37590348). {ECO:0000250}.
uniprot
proteins
mass_dalton
25029
uniprot
proteins
protein_family
MDFI family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17289077
uniprot
proteins
pubmed
37590348
uniprot
proteins
pubmed
9250874
uniprot
proteins
sequence_length
246
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250|UniProtKB:P70331}.
uniprot
proteins