PTGIS
entrez
5740
canonical
uniprot
Q16647
canonical
ensembl
ENSG00000124212
resolver
ensp
ENSP00000244043
resolver
enst
ENST00000244043
resolver
genesymbol
PTGIS
resolver
genesymbol_syn
CYP8
resolver
genesymbol_syn
CYP8A1
resolver
hgnc
HGNC:9603
resolver
uniprot
Q3MII8
resolver
uniprot
Q9HAX2
resolver
uniprot
Q9HAX3
resolver
uniprot
Q9HAX4
resolver
uniprot_entry
PTGIS_HUMAN
resolver
uniprot_sec
Q3MII8
resolver
uniprot_sec
Q9HAX2
resolver
uniprot_sec
Q9HAX3
resolver
uniprot_sec
Q9HAX4
resolver
amino_acid_sequence
MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP
uniprot
proteins
disease_involvement
DISEASE: Essential hypertension (EHT) [MIM:145500]: A condition in which blood pressure is consistently higher than normal with no identifiable cause. {ECO:0000269|PubMed:12372404}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
4.2.1.152
uniprot
proteins
ec_number
5.3.99.4
uniprot
proteins
function
FUNCTION: Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:12372404, PubMed:15115769, PubMed:18032380, PubMed:25623425). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323). {ECO:0000269|PubMed:12372404, ECO:0000269|PubMed:15115769, ECO:0000269|PubMed:17459323, ECO:0000269|PubMed:18032380, ECO:0000269|PubMed:25623425}.
uniprot
proteins
mass_dalton
57104
uniprot
proteins
mutagenesis
MUTAGEN 441; /note="C->H: Abolishes prostaglandin-I synthase activity."; /evidence="ECO:0000269|PubMed:15115769
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
11281454
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12372404
uniprot
proteins
pubmed
15115769
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17020766
uniprot
proteins
pubmed
17459323
uniprot
proteins
pubmed
18032380
uniprot
proteins
pubmed
25623425
uniprot
proteins
pubmed
8185632
uniprot
proteins
sequence_length
500
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q29626}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 1..20; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins