Cldn10
entrez
58187
canonical
uniprot
Q9Z0S6
canonical
ensembl
ENSMUSG00000022132
resolver
ensp
ENSMUSP00000041616
resolver
ensp
ENSMUSP00000071476
resolver
ensp
ENSMUSP00000097889
resolver
genesymbol
Cldn10
resolver
genesymbol_syn
Cldn10a
resolver
uniprot
E9PVC8
resolver
uniprot
E9PWP4
resolver
uniprot
E9QMP1
resolver
uniprot
Q8VC62
resolver
uniprot
Q9CX57
resolver
uniprot_entry
CLD10_MOUSE
resolver
uniprot_sec
E9PVC8
resolver
uniprot_sec
E9PWP4
resolver
uniprot_sec
E9QMP1
resolver
uniprot_sec
Q8VC62
resolver
uniprot_sec
Q9CX57
resolver
amino_acid_sequence
MASTALEIVAFVVSISGWVLVSSTLPTDYWKVSTIDGTVITTATYFANLWKICVTDSTGVANCKEFPSMLALDGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDQAKAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFDPLYMEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRMGYTYNGPTSAMSSRTKYQGGEGDFKTTGPSKQFDKNAYV
uniprot
proteins
function
FUNCTION: Forms paracellular channels: polymerizes in tight junction strands with cation- and anion-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. {ECO:0000269|PubMed:16804102, ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:20460438}.; FUNCTION: [Isoform 1]: Forms cation-selective paracellular channels. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function. {ECO:0000250|UniProtKB:P78369, ECO:0000269|PubMed:16804102, ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:20460438, ECO:0000269|PubMed:22891322}.; FUNCTION: [Isoform 2]: Forms anion-selective paracellular channels. In renal proximal tubules, it conveys selective chloride over hydrogencarbonate anion permeability which is required for renal chloride reabsorption and salt homeostasis. {ECO:0000269|PubMed:16804102, ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:35031570}.
uniprot
proteins
mass_dalton
24695
uniprot
proteins
mutagenesis
MUTAGEN Q9Z0S6-2:33; /note="R->D: Abolishes anion-selective permeability."; /evidence="ECO:0000269|PubMed:16804102"; MUTAGEN Q9Z0S6-2:62; /note="R->D: Abolishes anion-selective permeability."; /evidence="ECO:0000269|PubMed:16804102"; MUTAGEN Q9Z0S6-2:69; /note="K->D: Does not affect anion-selective permeability."; /evidence="ECO:0000269|PubMed:16804102
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
14698084
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16520537
uniprot
proteins
pubmed
16804102
uniprot
proteins
pubmed
17075866
uniprot
proteins
pubmed
19383724
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20460438
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22891322
uniprot
proteins
pubmed
28771254
uniprot
proteins
pubmed
35031570
uniprot
proteins
sequence_length
231
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell junction, tight junction {ECO:0000269|PubMed:16804102, ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:20460438}. Cell membrane {ECO:0000269|PubMed:16804102, ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:20460438}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell junction, tight junction {ECO:0000269|PubMed:16804102, ECO:0000269|PubMed:19383724, ECO:0000305|PubMed:35031570}. Cell membrane {ECO:0000269|PubMed:16804102, ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:35031570}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Endoplasmic reticulum {ECO:0000269|PubMed:19383724}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell junction, tight junction {ECO:0000269|PubMed:19383724}. Cell membrane {ECO:0000269|PubMed:19383724}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 5]: Endoplasmic reticulum {ECO:0000269|PubMed:19383724}.; SUBCELLULAR LOCATION: [Isoform 6]: Endoplasmic reticulum {ECO:0000269|PubMed:19383724}.
uniprot
proteins
transmembrane_region
TRANSMEM 1..21; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 81..101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins