Pdcl3
entrez
68833
canonical
uniprot
Q8BVF2
canonical
ensembl
ENSMUSG00000026078
resolver
ensp
ENSMUSP00000027247
resolver
enst
ENSMUST00000027247
resolver
genesymbol
Pdcl3
resolver
genesymbol_syn
Viaf1
resolver
uniprot
Q3TH06
resolver
uniprot
Q99JX2
resolver
uniprot
Q9D0W3
resolver
uniprot_entry
PDCL3_MOUSE
resolver
uniprot_sec
Q3TH06
resolver
uniprot_sec
Q99JX2
resolver
uniprot_sec
Q9D0W3
resolver
amino_acid_sequence
MQDPNADTEWNDILRKKGILPPKESLKELEEEEAEKEEQLLQQSVVKTYEDMTLEELEENEDEFSEEDERAIEMYRQQRLAEWKATQLKNKFGEVLEISGKDYVQEVTKAGEGLWVILHLYKQGIPLCSLINHHLSGLARKFPDVKFIKAISTTCIPNYPDRNLPTVFVYREGDIKAQFIGPLVFGGMNLTIDELEWKLSESGAIKTALEENPKKPIQDLLLSSVRGPVPMRRDSDSEDD
uniprot
proteins
function
FUNCTION: Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity). {ECO:0000250|UniProtKB:Q4KLJ8, ECO:0000250|UniProtKB:Q9H2J4, ECO:0000269|PubMed:26059764}.
uniprot
proteins
mass_dalton
27581
uniprot
proteins
post_translational_modification
PTM: N-terminal methionine acetylation destabilizes the protein. {ECO:0000250|UniProtKB:Q9H2J4}.
uniprot
proteins
protein_family
Phosducin family
uniprot
proteins
pubmed
15371430
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26059764
uniprot
proteins
pubmed
27496612
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27496612}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9H2J4}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9H2J4}.
uniprot
proteins