MITD1
entrez
129531
canonical
uniprot
Q8WV92
canonical
ensembl
ENSG00000158411
resolver
ensp
ENSP00000289359
resolver
ensp
ENSP00000387316
resolver
ensp
ENSP00000648273
resolver
ensp
ENSP00000780377
resolver
enst
ENST00000289359
resolver
genesymbol
MITD1
resolver
hgnc
HGNC:25207
resolver
uniprot
Q69YV0
resolver
uniprot_entry
MITD1_HUMAN
resolver
uniprot_sec
Q69YV0
resolver
amino_acid_sequence
MAKSGLRQDPQSTAAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEKEDGKYHKQIKIEENATGFSYESLFREYLNETVTEVWIEDPYIRHTHQLYNFLRFCEMLIKRPCKVKTIHLLTSLDEGIEQVQQSRGLQEIEESLRSHGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETTVDIFHKKHTKNI
uniprot
proteins
function
FUNCTION: Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex. {ECO:0000269|PubMed:23015756, ECO:0000269|PubMed:23045692}.
uniprot
proteins
mass_dalton
29314
uniprot
proteins
mutagenesis
MUTAGEN 69; /note="M->D: Abolishes interaction with CHMP1A, CHMP1B and CHMP2A."; /evidence="ECO:0000269|PubMed:23045692"; MUTAGEN 73; /note="E->A: Abolishes interaction with CHMP1A, CHMP1B and CHMP2A. Abolishes location at the midbody."; /evidence="ECO:0000269|PubMed:23045692"; MUTAGEN 132; /note="Y->A: Abolishes homodimerization; when associated with A-221 and A-225."; /evidence="ECO:0000269|PubMed:23045692"; MUTAGEN 168; /note="R->E: Strongly reduces binding to membranes; when associated with E-221 and E-231."; /evidence="ECO:0000269|PubMed:23045692"; MUTAGEN 220; /note="R->E: Strongly reduces binding to membranes; when associated with E-168 and E-231."; /evidence="ECO:0000269|PubMed:23045692"; MUTAGEN 221; /note="F->A: Abolishes homodimerization; when associated with A-132 and A-225."; /evidence="ECO:0000269|PubMed:23045692"; MUTAGEN 225; /note="Y->A: Abolishes homodimerization; when associated with A-132 and A-221."; /evidence="ECO:0000269|PubMed:23045692"; MUTAGEN 231; /note="R->E: Strongly reduces binding to membranes; when associated with E-221 and E-220."; /evidence="ECO:0000269|PubMed:23045692
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16730941
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19129480
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23015756
uniprot
proteins
pubmed
23045692
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=During cytokinesis, recruited to the midbody via interaction with CHMP1A. Interacts with membranes enriched in phosphoinositides.
uniprot
proteins