Ace2
entrez
302668
canonical
uniprot
Q5EGZ1
canonical
ensembl
ENSRNOG00000031665
resolver
ensembl
ENSRNOG00055028217
resolver
ensp
ENSRNOP00000070410
resolver
ensp
ENSRNOP00055040140
resolver
enst
ENSRNOT00000080730
resolver
enst
ENSRNOT00055048829
resolver
genesymbol
Ace2
resolver
uniprot
C7ECU5
resolver
uniprot_entry
ACE2_RAT
resolver
uniprot_entry
C7ECU5_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril, enalaprilat. {ECO:0000269|PubMed:15231706}.
uniprot
proteins
amino_acid_sequence
MSSSCWLLLSLVAVATAQSLIEEKAESFLNKFNQEAEDLSYQSSLASWNYNTNITEENAQKMNEAAAKWSAFYEEQSKIAQNFSLQEIQNATIKRQLKALQQSGSSALSPDKNKQLNTILNTMSTIYSTGKVCNSMNPQECFLLEPGLDEIMATSTDYNRRLWAWEGWRAEVGKQLRPLYEEYVVLKNEMARANNYEDYGDYWRGDYEAEGVEGYNYNRNQLIEDVENTFKEIKPLYEQLHAYVRTKLMEVYPSYISPTGCLPAHLLGDMWGRFWTNLYPLTTPFLQKPNIDVTDAMVNQSWDAERIFKEAEKFFVSVGLPQMTPGFWTNSMLTEPGDDRKVVCHPTAWDLGHGDFRIKMCTKVTMDNFLTAHHEMGHIQYDMAYAKQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLPSNFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFQDKIPREQWTKKWWEMKREIVGVVEPLPHDETYCDPASLFHVSNDYSFIRYYTRTIYQFQFQEALCQAAKHDGPLHKCDISNSTEAGQKLLNMLSLGNSGPWTLALENVVGSRNMDVKPLLNYFQPLFVWLKEQNRNSTVGWSTDWSPYADQSIKVRISLKSALGKNAYEWTDNEMYLFRSSVAYAMREYFSREKNQTVPFGEADVWVSDLKPRVSFNFFVTSPKNVSDIIPRSEVEEAIRMSRGRINDIFGLNDNSLEFLGIYPTLKPPYEPPVTIWLIIFGVVMGTVVVGIVILIVTGIKGRKKKNETKREENPYDSMDIGKGESNAGFQNSDDAQTSF
uniprot
proteins
ec_number
3.4.17.-
uniprot
proteins
ec_number
3.4.17.23
uniprot
proteins
function
FUNCTION: Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity. {ECO:0000250|UniProtKB:Q9BYF1}.
uniprot
proteins
mass_dalton
92491
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:15231706}.; PTM: Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1 (By similarity). {ECO:0000250}.; PTM: Phosphorylated. Phosphorylation at Tyr-781 probably inhibits interaction with AP2M1 and enables interactions with proteins containing SH2 domains. {ECO:0000250|UniProtKB:Q9BYF1}.; PTM: Ubiquitinated. Ubiquitinated on Lys-788 via 'Lys-48'-linked ubiquitin. 'Lys-48'-linked deubiquitinated by USP50 on the Lys-788; leading to its stabilization. {ECO:0000250|UniProtKB:Q9BYF1}.
uniprot
proteins
protein_family
Peptidase M2 family
uniprot
proteins
pubmed
12075344
uniprot
proteins
pubmed
15231706
uniprot
proteins
pubmed
15452268
uniprot
proteins
pubmed
15671045
uniprot
proteins
pubmed
15949646
uniprot
proteins
sequence_length
805
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Processed angiotensin-converting enzyme 2]: Secreted {ECO:0000250}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BYF1}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8R0I0}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9BYF1}. Apical cell membrane {ECO:0000250|UniProtKB:Q9BYF1}. Note=Detected in both cell membrane and cytoplasm in neurons. {ECO:0000250|UniProtKB:Q8R0I0}.
uniprot
proteins
transmembrane_region
TRANSMEM 741..761; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01354
uniprot
proteins