Ngfr
entrez
24596
canonical
uniprot
P07174
canonical
ensembl
ENSRNOG00000005392
resolver
ensp
ENSRNOP00000007268
resolver
enst
ENSRNOT00000007268
resolver
genesymbol
Ngfr
resolver
genesymbol_syn
Tnfrsf16
resolver
uniprot
G3V6P1
resolver
uniprot_entry
G3V6P1_RAT
resolver
uniprot_entry
TNR16_RAT
resolver
amino_acid_sequence
MRRAGAACSAMDRLRLLLLLILGVSSGGAKETCSTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDNVTFSDVVSATEPCKPCTECLGLQSMSAPCVEADDAVCRCAYGYYQDEETGHCEACSVCEVGSGLVFSCQDKQNTVCEECPEGTYSDEANHVDPCLPCTVCEDTERQLRECTPWADAECEEIPGRWIPRSTPPEGSDSTAPSTQEPEVPPEQDLVPSTVADMVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQTHTQTASGQALKGDGNLYSSLPLTKREEVEKLLNGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWGAQDSATLDALLAALRRIQRADIVESLCSESTATSPV
uniprot
proteins
function
FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4 (PubMed:15131306, PubMed:18596692, PubMed:3027580). Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:22155786, PubMed:24908487). In response to proNGF binding, the heterodimeric receptor with SORCS2 activates a signaling cascade that leads to decreased Rac activity, reorganization of the actin cytoskeleton and neuronal growth cone collapse (PubMed:22155786). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells (PubMed:10514511, PubMed:10985348, PubMed:24908487). Plays a role in the inactivation of RHOA (By similarity). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:P08138, ECO:0000250|UniProtKB:Q9Z0W1, ECO:0000269|PubMed:10514511, ECO:0000269|PubMed:10985348, ECO:0000269|PubMed:15131306, ECO:0000269|PubMed:18596692, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:3027580}.
uniprot
proteins
mass_dalton
45433
uniprot
proteins
mutagenesis
MUTAGEN 61; /note="N->D: Loss of a glycosylation site."; /evidence="ECO:0000269|PubMed:20036257"; MUTAGEN 257; /note="C->A: Alters mode of dimerization, but does not abolish dimerization."; /evidence="ECO:0000269|PubMed:27056327"; MUTAGEN 257; /note="C->I: No effect on dimerization. Loss of dimerization; when associated with I-266."; /evidence="ECO:0000269|PubMed:27056327"; MUTAGEN 262; /note="A->I: No effect on dimerization."; /evidence="ECO:0000269|PubMed:27056327"; MUTAGEN 266; /note="G->I: No effect on dimerization. Loss of dimerization; when associated with I-257."; /evidence="ECO:0000269|PubMed:27056327
uniprot
proteins
post_translational_modification
PTM: Subject to intramembrane proteolytic cleavage by the gamma-secretase complex, giving rise to an intracellular fragment that is rapidly degraded via the proteasome. {ECO:0000269|PubMed:27056327}.; PTM: N- and O-glycosylated. {ECO:0000269|PubMed:20036257}.; PTM: Phosphorylated on serine residues.
uniprot
proteins
pubmed
10514511
uniprot
proteins
pubmed
10985348
uniprot
proteins
pubmed
11150334
uniprot
proteins
pubmed
12095158
uniprot
proteins
pubmed
1446821
uniprot
proteins
pubmed
15131306
uniprot
proteins
pubmed
15378608
uniprot
proteins
pubmed
16498402
uniprot
proteins
pubmed
18596692
uniprot
proteins
pubmed
20036257
uniprot
proteins
pubmed
22155786
uniprot
proteins
pubmed
24908487
uniprot
proteins
pubmed
27056327
uniprot
proteins
pubmed
27457814
uniprot
proteins
pubmed
3027580
uniprot
proteins
pubmed
9305641
uniprot
proteins
pubmed
9927421
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20036257, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:3027580}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:P08138}. Perikaryon {ECO:0000269|PubMed:22155786}. Cell projection, growth cone {ECO:0000269|PubMed:22155786}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z0W1}.
uniprot
proteins
transmembrane_region
TRANSMEM 254..274; /note="Helical"; /evidence="ECO:0000305|PubMed:27056327
uniprot
proteins