C0HMG8
uniprot
C0HMG8
canonical
amino_acid_sequence
MRTKFVIAQNQDVRLMLKITPVQRESFHLWSLKLRAGGATWPKAGQAKVKSQKNCPGWQRTNPRFCMALATVNGSTCAWDSDSSP
uniprot
proteins
function
FUNCTION: Acts as a cytoplasmic regulator of pluripotency and embryonic development (PubMed:41298451). Promotes the transition from the naive to the primed pluripotency state and safeguards the primed state (PubMed:41298451). Promotes L1TD1 condensate formation and prevents L1TD1 from binding and stabilizing transcripts of the pluripotency regulator TFCP2L1 (PubMed:41298451). Stabilizes P-bodies in epiblast stem cells which are enriched with nuclear-encoded mitochondrial mRNAs, thereby promoting degradation of the mRNAs (PubMed:41298451). Controls metabolic remodeling during embryo implantation by regulating mitochondrial oxidative phosphorylation (PubMed:41298451). {ECO:0000269|PubMed:41298451}.
uniprot
proteins
mass_dalton
9535
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
41298451
uniprot
proteins
sequence_length
85
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:41298451}. Cytoplasm, P-body {ECO:0000269|PubMed:41298451}. Note=Exhibits punctate cytoplasmic localization (PubMed:41298451). Shows partial colocalization with P-bodies (PubMed:41298451). {ECO:0000269|PubMed:41298451}.
uniprot
proteins