Slco1a1
entrez
50572
canonical
uniprot
P46720
canonical
ensembl
ENSRNOG00000036984
resolver
ensembl
ENSRNOG00055010204
resolver
ensembl
ENSRNOG00060008158
resolver
ensembl
ENSRNOG00065005596
resolver
ensp
ENSRNOP00000078030
resolver
ensp
ENSRNOP00055013897
resolver
ensp
ENSRNOP00060010337
resolver
ensp
ENSRNOP00065005843
resolver
enst
ENSRNOT00000102966
resolver
enst
ENSRNOT00055017285
resolver
enst
ENSRNOT00060013560
resolver
enst
ENSRNOT00065008315
resolver
genesymbol
Slco1a1
resolver
genesymbol_syn
Oatp1
resolver
genesymbol_syn
Oatp1a1
resolver
genesymbol_syn
Slc21a1
resolver
uniprot_entry
SO1A1_RAT
resolver
amino_acid_sequence
MEETEKKIATQEGRLFSKMKVFLLSLTCACLTKSLSGVYMNSMLTQIERQFDISTSVAGLINGSFEIGNLFFIVFVSYFGTKLHRPVVIGIGCVIMGLGCLLMSLPHFFMGRYEYETTISPTGNLSSNSFLCMENRTQTLKPTQDPAECVKEMKSLMWICVMVGNIIRGIGETPIVPLGISYIEDFAKSENSPLYIGILEMGKVAGPIFGLLLGSYCAQIYVDIGSVNTDDLTITPSDTRWVGAWWIGFLVCAGVNILTSIPFFFLPKALPKKGQQENVAVTKDGKVEKYGGQAREENLGITKDFLTFMKRLFCNPIYMLFILTSVLQVNGFINKFTFLPKYLEQQYGKSTAEAIFLIGVYSLPPICLGYLIGGFIMKKFKITVKKAAYLAFCLSVFEYLLFLCHFMLTCDNAAVAGLTTSYKGVQHQLHVESKVLADCNTRCSCSTNTWDPVCGDNGVAYMSACLAGCKKFVGTGTNMVFQDCSCIQSLGNSSAVLGLCKKGPECANRLQYFLILTIIISFIYSLTAIPGYMVFLRCVKSEEKSLGVGLHTFCIRVFAGIPAPVYFGALIDRTCLHWGTLKCGQRGACRMYDINSFRHIYLGLPIALRGSSYLPAFFILILMRKFQFPGDIDSSATDHTEMMLGEKESEHTDVHGSPQVENDGELKTKL
uniprot
proteins
function
FUNCTION: Mediates the Na(+)-independent transport of organic anions such as steroid sulfate conjugates (dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate), conjugated (taurocholate) and unconjugated (cholate) bile acids, prostaglandin E2 (PGE2) and L-thyroxine T4 (PubMed:19129463). Also capable of transporting sulfobromophthalein (BSP), ouabain and gadoxetate (By similarity). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). {ECO:0000250|UniProtKB:Q9QXZ6, ECO:0000269|PubMed:19129463}.
uniprot
proteins
mass_dalton
74178
uniprot
proteins
mutagenesis
MUTAGEN 107; /note="H->Q: Loss of pH-sensitivity of estrone 3-sulfate transport."; /evidence="ECO:0000269|PubMed:19129463"; MUTAGEN 666..670; /note="Missing: Abolishes binding to PDZK1."; /evidence="ECO:0000269|PubMed:15994332
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:18308854, ECO:0000269|PubMed:8278353}.
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
15994332
uniprot
proteins
pubmed
16519530
uniprot
proteins
pubmed
18308854
uniprot
proteins
pubmed
19129463
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8278353
uniprot
proteins
sequence_length
670
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:18308854}; Multi-pass membrane protein {ECO:0000269|PubMed:18308854}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..40; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 60..80; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 87..111; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 156..184; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 243..267; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 312..333; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 354..377; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 382..405; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 514..536; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 546..571; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 606..623; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins