Ell2
entrez
192657
canonical
uniprot
Q3UKU1
canonical
ensembl
ENSMUSG00000001542
resolver
ensp
ENSMUSP00000001583
resolver
enst
ENSMUST00000001583
resolver
genesymbol
Ell2
resolver
uniprot
E9QPE1
resolver
uniprot_entry
ELL2_MOUSE
resolver
uniprot_sec
E9QPE1
resolver
amino_acid_sequence
MAAGGAAGLREEQRYGLACGRLGQDNITVLHVKLTETAIRALETYQSHKNLIPFRPSIQFQGLQGLMKIPKNDPFNEVQNFNFYLSNVGRDNPQGSFDCIQQTLSSSGASQLNCLGFIQDKITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYVGKRVQIRKAPQAISDTVPERKRSTPMNPANTIRKMHSGNSVSQRPYRDRVIHLLALKAYKKPELLARLQKDGVNQKDKNSLGAILQQVANLNPKDLSYTLKDYVFKELQRDWPGYSETDRQTLDLVLSRKLNPSQNASTSRSESPLCSSKDAASSPQKRPLDSDFIDPLMNKKARISHLTNRVPPTLNGYLNPTSEKSCAGLLPPPAAAAIPTLSPLPSTHLPVSNPPQTVNSNSNSPSTPEGLGTQDLPVDSFSQNGSIFEDQQEKYTSRTCLETLPPSSALLKCPKPMEEEHPVSHKKSKKKSKKHKEKDQIKKLDIETMEEKEEDLQREETAKLSNASPNPNEGVKEGCTASMEPSSALELPDYLIKYIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQRKRLSPGSKEYQNVHEEVLQEYQKIKQSSPNYHEEKYRCEYLHNKLAHIKRLIGEFDQQQAESWH
uniprot
proteins
function
FUNCTION: Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (By similarity). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. {ECO:0000250, ECO:0000269|PubMed:19749764, ECO:0000269|PubMed:21832080}.
uniprot
proteins
mass_dalton
72125
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by SIAH1, leading to its degradation by the proteasome. Interaction with AFF4 stabilizes ELL2 and prevents ELL2 ubiquitination (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
ELL/occludin family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19749764
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21832080
uniprot
proteins
sequence_length
639
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins