GAS6
entrez
2621
canonical
uniprot
Q14393
canonical
ensembl
ENSG00000183087
resolver
ensp
ENSP00000331831
resolver
genesymbol
GAS6
resolver
genesymbol_syn
AXLLG
resolver
hgnc
HGNC:4168
resolver
uniprot
B3KRQ7
resolver
uniprot
B3KVL4
resolver
uniprot
B4DZY7
resolver
uniprot
E9PBL7
resolver
uniprot
Q6IMN1
resolver
uniprot
Q7Z7N3
resolver
uniprot_entry
B4DZY7_HUMAN
resolver
uniprot_entry
GAS6_HUMAN
resolver
uniprot_sec
B3KRQ7
resolver
uniprot_sec
B3KVL4
resolver
uniprot_sec
E9PBL7
resolver
uniprot_sec
Q6IMN1
resolver
uniprot_sec
Q7Z7N3
resolver
amino_acid_sequence
MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA
uniprot
proteins
function
FUNCTION: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. {ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:18840707}.; FUNCTION: (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688). {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:23084921}.
uniprot
proteins
mass_dalton
74925
uniprot
proteins
mutagenesis
MUTAGEN 310; /note="R->E: Strongly reduced affinity for AXL. Abolishes phosphorylation of AXL."; /evidence="ECO:0000269|PubMed:16362042"; MUTAGEN 312; /note="K->E: Strongly reduced affinity for AXL. Abolishes phosphorylation of AXL."; /evidence="ECO:0000269|PubMed:16362042"; MUTAGEN 487; /note="F->A: Decreases activation of AXL."; /evidence="ECO:0000269|PubMed:8621659"; MUTAGEN 620; /note="L->A: Reduces affinity for AXL 15-fold and decreases activation of AXL."; /evidence="ECO:0000269|PubMed:8621659"; MUTAGEN 660; /note="Y->A: Reduces affinity for AXL 3-fold."; /evidence="ECO:0000269|PubMed:8621659
uniprot
proteins
post_translational_modification
PTM: [Isoform 2]: Proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL. {ECO:0000269|PubMed:9326369}.; PTM: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. {ECO:0000255|PROSITE-ProRule:PRU00463}.
uniprot
proteins
pubmed
12364394
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15108283
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16362042
uniprot
proteins
pubmed
17005688
uniprot
proteins
pubmed
18840707
uniprot
proteins
pubmed
21501828
uniprot
proteins
pubmed
23084921
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
7854420
uniprot
proteins
pubmed
7867073
uniprot
proteins
pubmed
8336730
uniprot
proteins
pubmed
8621659
uniprot
proteins
pubmed
8939948
uniprot
proteins
pubmed
9326368
uniprot
proteins
pubmed
9326369
uniprot
proteins
sequence_length
678
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9326369}.
uniprot
proteins