DSTYK
entrez
25778
canonical
uniprot
Q6XUX3
canonical
ensembl
ENSG00000133059
resolver
ensp
ENSP00000356129
resolver
ensp
ENSP00000356130
resolver
ensp
ENSP00000563295
resolver
ensp
ENSP00000563296
resolver
ensp
ENSP00000563297
resolver
ensp
ENSP00000563299
resolver
genesymbol
DSTYK
resolver
genesymbol_syn
KIAA0472
resolver
genesymbol_syn
RIP5
resolver
genesymbol_syn
RIPK5
resolver
genesymbol_syn
SGK496
resolver
hgnc
HGNC:29043
resolver
uniprot
B7ZL64
resolver
uniprot
O75060
resolver
uniprot
Q17R94
resolver
uniprot
Q5RKT0
resolver
uniprot
Q6IN87
resolver
uniprot
Q6P997
resolver
uniprot
Q86Y03
resolver
uniprot
Q9P1S5
resolver
uniprot_entry
DUSTY_HUMAN
resolver
uniprot_sec
B7ZL64
resolver
uniprot_sec
O75060
resolver
uniprot_sec
Q17R94
resolver
uniprot_sec
Q5RKT0
resolver
uniprot_sec
Q6IN87
resolver
uniprot_sec
Q6P997
resolver
uniprot_sec
Q86Y03
resolver
uniprot_sec
Q9P1S5
resolver
amino_acid_sequence
MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHNHTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQDCNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAHQGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDLVNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESERSPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAKALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLQGIMNRLCKSNSEQPNRGLDDST
uniprot
proteins
disease_involvement
DISEASE: Congenital anomalies of the kidney and urinary tract 1 (CAKUT1) [MIM:610805]: A disorder encompassing a broad spectrum of renal and urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves and ureter abnormalities. Congenital anomalies of kidney and urinary tract are the commonest cause of chronic kidney disease in children. {ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:34608560, ECO:0000269|PubMed:37746849}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Spastic paraplegia 23, autosomal recessive (SPG23) [MIM:270750]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG23 is an autosomal recessive form characterized by childhood-onset of gait difficulties and pigmentary abnormalities, including premature graying of the hair and vitiligo-like or hyperpigmented skin lesions. {ECO:0000269|PubMed:28157540}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.12.1
uniprot
proteins
function
FUNCTION: Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). Involved in normal skeletal segmentation and spine formation, via positively regulating late-stage endosomal trafficking in notochord cells (By similarity). Required for normal spatial learning and memory, independent of normal brain development (By similarity). May be required for normal urinary tract and kidney formation (By similarity). {ECO:0000250|UniProtKB:Q4VSN1, ECO:0000250|UniProtKB:Q6XUX1, ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}.
uniprot
proteins
mass_dalton
105206
uniprot
proteins
mutagenesis
MUTAGEN 681; /note="K->Q: No change."; /evidence="ECO:0000269|PubMed:15178406
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
15178406
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17123648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
23862974
uniprot
proteins
pubmed
28157540
uniprot
proteins
pubmed
34608560
uniprot
proteins
pubmed
37746849
uniprot
proteins
pubmed
9455484
uniprot
proteins
sequence_length
929
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17123648, ECO:0000269|PubMed:23862974}. Cell membrane {ECO:0000250|UniProtKB:Q6XUX1}. Apical cell membrane {ECO:0000269|PubMed:23862974}. Basolateral cell membrane {ECO:0000269|PubMed:23862974}. Cell junction {ECO:0000250|UniProtKB:Q6XUX1}. Note=Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane (By similarity). Detected in basolateral and apical membranes of all tubular epithelia. {ECO:0000250|UniProtKB:Q6XUX1, ECO:0000269|PubMed:23862974}.
uniprot
proteins