AGAP1
entrez
116987
canonical
uniprot
Q9UPQ3
canonical
ensembl
ENSG00000157985
resolver
ensp
ENSP00000307634
resolver
ensp
ENSP00000338378
resolver
ensp
ENSP00000386897
resolver
ensp
ENSP00000387174
resolver
enst
ENST00000409538
resolver
genesymbol
AGAP1
resolver
genesymbol_syn
CENTG2
resolver
genesymbol_syn
KIAA1099
resolver
hgnc
HGNC:16922
resolver
uniprot
B2RTX7
resolver
uniprot
B2RZG9
resolver
uniprot
E7EUN2
resolver
uniprot
Q541S5
resolver
uniprot
Q6P9D7
resolver
uniprot
Q9NV93
resolver
uniprot_entry
AGAP1_HUMAN
resolver
uniprot_entry
B2RZG9_HUMAN
resolver
uniprot_entry
E7EUN2_HUMAN
resolver
uniprot_sec
B2RTX7
resolver
uniprot_sec
Q541S5
resolver
uniprot_sec
Q6P9D7
resolver
uniprot_sec
Q9NV93
resolver
activity_regulation
ACTIVITY REGULATION: GAP activity stimulated by phosphatidylinositol 3,4,5-trisphosphate (PIP3) and, to a lesser extent, by phosphatidylinositol 4,5-bisphosphate (PIP2). Phosphatidic acid potentiates PIP2 stimulation.
uniprot
proteins
amino_acid_sequence
MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPKTNGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQWSEATVIANSAISSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLSRRNNNRNNSSGRVPTII
uniprot
proteins
function
FUNCTION: GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system. {ECO:0000269|PubMed:12640130}.
uniprot
proteins
mass_dalton
94470
uniprot
proteins
mutagenesis
MUTAGEN 647; /note="C->S: Loss of GAP activity."; /evidence="ECO:0000269|PubMed:12388557"; MUTAGEN 652; /note="R->K: Loss of GAP activity. No effect on AP-3-binding."; /evidence="ECO:0000269|PubMed:12388557
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines. {ECO:0000269|PubMed:15381706}.
uniprot
proteins
protein_family
Centaurin gamma-like family
uniprot
proteins
pubmed
10470851
uniprot
proteins
pubmed
12388557
uniprot
proteins
pubmed
12640130
uniprot
proteins
pubmed
12967569
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15381706
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15892143
uniprot
proteins
pubmed
16079295
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
857
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12388557, ECO:0000269|PubMed:12640130}. Note=Associates with the endocytic compartment.
uniprot
proteins