CBLIF
entrez
2694
canonical
uniprot
P27352
canonical
ensembl
ENSG00000134812
resolver
ensp
ENSP00000257248
resolver
genesymbol
CBLIF
resolver
genesymbol_syn
GIF
resolver
genesymbol_syn
IFMH
resolver
hgnc
HGNC:4268
resolver
uniprot
B2RAN8
resolver
uniprot
B4DVZ1
resolver
uniprot_entry
IF_HUMAN
resolver
uniprot_sec
B2RAN8
resolver
uniprot_sec
B4DVZ1
resolver
amino_acid_sequence
MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIAMNLAGAYNLKAQKLLTYQLMSSDNNDLTIGQLGLTIMALTSSCRDPGDKVSILQRQMENWAPSSPNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKTLLANSSPFNVDTGAMATLALTCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPSKKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPSLKGKTYLDVPQVTCSPDHEVQPTLPSNPGPGPTSASNITVIYTINNQLRGVELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFETTMTSWGLVVSSINNIAENVNHKTYWQFLSGVTPLNEGVADYIPFNHEHITANFTQY
uniprot
proteins
disease_involvement
DISEASE: Hereditary intrinsic factor deficiency (IFD) [MIM:261000]: Autosomal recessive disorder characterized by megaloblastic anemia. {ECO:0000269|PubMed:15738392}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis.
uniprot
proteins
mass_dalton
45416
uniprot
proteins
protein_family
Eukaryotic cobalamin transport proteins family
uniprot
proteins
pubmed
14695536
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15738392
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17954916
uniprot
proteins
pubmed
20237569
uniprot
proteins
pubmed
2071148
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins