CORT
entrez
1325
canonical
uniprot
O00230
canonical
ensembl
ENSG00000241563
resolver
ensp
ENSP00000366248
resolver
enst
ENST00000377049
resolver
genesymbol
CORT
resolver
hgnc
HGNC:2257
resolver
uniprot
Q5T6G0
resolver
uniprot
Q6UX11
resolver
uniprot
Q8IUV6
resolver
uniprot_entry
CORT_HUMAN
resolver
uniprot_entry
Q8IUV6_HUMAN
resolver
uniprot_sec
Q5T6G0
resolver
uniprot_sec
Q6UX11
resolver
amino_acid_sequence
MPLSPGLLLLLLSGATATAALPLEGGPTGRDSEHMQEAAGIRKSSLLTFLAWWFEWTSQASAGPLIGEEAREVARRQEGAPPQQSARRDRMPCRNFFWKTFSSCK
uniprot
proteins
function
FUNCTION: Precursor of neuropeptides that bind to all somatostatin receptor (SSTR) subtypes (PubMed:9125122). Inhibits cAMP production induced by forskolin through SSTRs (PubMed:9125122). {ECO:0000269|PubMed:9125122}.; FUNCTION: [Cortistatin-14]: Neuropeptide with neuronal depressant and sleep-modulating properties (By similarity). Acts as a ligand for MRGPRX2 receptor in mast cells (PubMed:12915402, PubMed:34789874, PubMed:34789875). {ECO:0000250|UniProtKB:Q62949, ECO:0000269|PubMed:12915402, ECO:0000269|PubMed:34789874, ECO:0000269|PubMed:34789875}.
uniprot
proteins
mass_dalton
11532
uniprot
proteins
protein_family
Somatostatin family
uniprot
proteins
pubmed
12915402
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
34789874
uniprot
proteins
pubmed
34789875
uniprot
proteins
pubmed
9125122
uniprot
proteins
pubmed
9205124
uniprot
proteins
sequence_length
105
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9125122}.; SUBCELLULAR LOCATION: [Cortistatin-14]: Secreted {ECO:0000250|UniProtKB:Q62949}.
uniprot
proteins