FUT3
entrez
2525
canonical
uniprot
P21217
canonical
ensembl
ENSG00000171124
resolver
ensembl
ENSG00000292063
resolver
ensp
ENSP00000305603
resolver
ensp
ENSP00000416443
resolver
ensp
ENSP00000465804
resolver
ensp
ENSP00000468123
resolver
ensp
ENSP00000517811
resolver
ensp
ENSP00000517812
resolver
ensp
ENSP00000517813
resolver
ensp
ENSP00000517814
resolver
enst
ENST00000303225
resolver
enst
ENST00000458379
resolver
enst
ENST00000589620
resolver
enst
ENST00000589918
resolver
enst
ENST00000709634
resolver
enst
ENST00000709635
resolver
enst
ENST00000709636
resolver
enst
ENST00000709637
resolver
genesymbol
FUT3
resolver
genesymbol_syn
FT3B
resolver
genesymbol_syn
LE
resolver
hgnc
HGNC:4014
resolver
uniprot
A8K737
resolver
uniprot
B5U7U9
resolver
uniprot
B5U7V0
resolver
uniprot
Q32NE7
resolver
uniprot
Q99448
resolver
uniprot
Q99449
resolver
uniprot_entry
A8K737_HUMAN
resolver
uniprot_entry
FUT3_HUMAN
resolver
uniprot_sec
B5U7U9
resolver
uniprot_sec
B5U7V0
resolver
uniprot_sec
Q32NE7
resolver
uniprot_sec
Q99448
resolver
uniprot_sec
Q99449
resolver
amino_acid_sequence
MDPLGAAKPQWPWRRCLAALLFQLLVAVCFFSYLRVSRDDATGSPRAPSGSSRQDTTPTRPTLLILLRTWPFHIPVALSRCSEMVPGTADCHITADRKVYPQADMVIVHHWDIMSNPKSRLPPSPRPQGQRWIWFNLEPPPNCQHLEALDRYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKPDSARVRYYQSLQAHLKVDVYGRSHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWKLQQESRYQTVRSIAAWFT
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.1.152
uniprot
proteins
ec_number
2.4.1.65
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors (PubMed:11058871, PubMed:12668675, PubMed:1977660). Through its catalytic activity, participates in the synthesis of antigens of the Lewis blood group system, i.e. Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens (PubMed:11058871, PubMed:12668675, PubMed:1977660). Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sLe(a) expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration (PubMed:11058871, PubMed:12668675, PubMed:27453266). Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin (PubMed:11058871, PubMed:29593094). Prefers type 1 chain over type 2 acceptors (PubMed:7721776). Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred (PubMed:7721776). Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme (PubMed:1977660). {ECO:0000269|PubMed:11058871, ECO:0000269|PubMed:12668675, ECO:0000269|PubMed:1977660, ECO:0000269|PubMed:27453266, ECO:0000269|PubMed:7721776}.
uniprot
proteins
mass_dalton
42117
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:1977660, ECO:0000269|PubMed:29593094}.
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:7721776}.
uniprot
proteins
protein_family
Glycosyltransferase 10 family
uniprot
proteins
pubmed
10211701
uniprot
proteins
pubmed
11058871
uniprot
proteins
pubmed
12668675
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1977660
uniprot
proteins
pubmed
27453266
uniprot
proteins
pubmed
29593094
uniprot
proteins
pubmed
7650030
uniprot
proteins
pubmed
7721776
uniprot
proteins
pubmed
7961897
uniprot
proteins
pubmed
8063716
uniprot
proteins
pubmed
8219240
uniprot
proteins
pubmed
8240322
uniprot
proteins
pubmed
8240337
uniprot
proteins
pubmed
8801770
uniprot
proteins
pubmed
9268337
uniprot
proteins
pubmed
9703429
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein {ECO:0000269|PubMed:1977660}. Note=Membrane-bound form in trans cisternae of Golgi.
uniprot
proteins
transmembrane_region
TRANSMEM 16..34; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255, ECO:0000269|PubMed:1977660
uniprot
proteins