Gpr3
entrez
14748
canonical
uniprot
P35413
canonical
ensembl
ENSMUSG00000049649
resolver
ensp
ENSMUSP00000062083
resolver
ensp
ENSMUSP00000101531
resolver
enst
ENSMUST00000052090
resolver
enst
ENSMUST00000105911
resolver
genesymbol
Gpr3
resolver
genesymbol_syn
Gpcr3
resolver
uniprot
Q3USD4
resolver
uniprot_entry
GPR3_MOUSE
resolver
uniprot_sec
Q3USD4
resolver
activity_regulation
ACTIVITY REGULATION: GPR3 bound to the lipid agonist is in an equilibrium between monomeric and dimeric states. G protein engagement leads to dissociation of the dimer, and efficient coupling and signaling of the Gs protein. {ECO:0000250|UniProtKB:P46089}.
uniprot
proteins
amino_acid_sequence
MMWGAGSSMAWFSAGSGSVNVSSVDPVEEPTGPATLLPSPRAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAADFCIGSPEMSLMLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWVGALGLGLVPVLAWNCRDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDADSPRLYTYLTLLPATYNSMINPVIYAFRNQDVQKVLWAICCCCSTSKIPFRSRSPSDV
uniprot
proteins
function
FUNCTION: Constitutively active G protein-coupled receptor that maintains high cAMP levels and contributes to several processes, including meiotic arrest in oocytes and neuronal development, through activation of intracellular signaling pathways (PubMed:15956199, PubMed:19259266). Essential activator of thermogenic adipocytes, where it drives thermogenesis via constitutive G(s)-coupling activity in the absence of ligand (PubMed:26455425, PubMed:34048700). May be activated by lipid-derived agonists such as oleoylethanolamide (OEA), oleic acid or sphingosine 1-phosphate leading to activation of the G(s)/cAMP/PKA signaling pathway (By similarity). Plays a potential role in modulating brain functions, including behavioral responses to stress and amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granule neurons via PKA, ERK, and PI3K-mediated signaling pathways (PubMed:34871769). {ECO:0000250|UniProtKB:P46089, ECO:0000269|PubMed:15956199, ECO:0000269|PubMed:19259266, ECO:0000269|PubMed:26455425, ECO:0000269|PubMed:34048700, ECO:0000269|PubMed:34871769}.
uniprot
proteins
mass_dalton
35453
uniprot
proteins
mutagenesis
MUTAGEN 133; /note="D->A: Loss of plasma membrane localization; when associated with A-134."; /evidence="ECO:0000269|PubMed:34871769"; MUTAGEN 134; /note="R->A: Loss of plasma membrane localization; when associated with A-133."; /evidence="ECO:0000269|PubMed:34871769
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15956199
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19259266
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26455425
uniprot
proteins
pubmed
34048700
uniprot
proteins
pubmed
34871769
uniprot
proteins
pubmed
8262253
uniprot
proteins
sequence_length
330
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:34871769}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..62; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 75..98; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 111..132; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 154..173; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 199..217; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 246..272; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 278..299; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins