MOB1B
entrez
92597
canonical
uniprot
Q7L9L4
canonical
ensembl
ENSG00000173542
resolver
ensp
ENSP00000310189
resolver
ensp
ENSP00000379366
resolver
genesymbol
MOB1B
resolver
genesymbol
MOBKL1A
resolver
genesymbol_syn
MOB4A
resolver
genesymbol_syn
MOBKL1A
resolver
hgnc
HGNC:29801
resolver
uniprot
B2R8U6
resolver
uniprot
B3KSH6
resolver
uniprot
B4DRY3
resolver
uniprot
Q8IY23
resolver
uniprot_entry
B3KSH6_HUMAN
resolver
uniprot_entry
MOB1B_HUMAN
resolver
uniprot_sec
B2R8U6
resolver
uniprot_sec
B4DRY3
resolver
uniprot_sec
Q8IY23
resolver
amino_acid_sequence
MSFLFGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR
uniprot
proteins
function
FUNCTION: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:19739119}.
uniprot
proteins
mass_dalton
25091
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1. {ECO:0000269|PubMed:18328708}.
uniprot
proteins
protein_family
MOB1/phocein family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15067004
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18328708
uniprot
proteins
pubmed
19739119
uniprot
proteins
pubmed
22814378
uniprot
proteins
sequence_length
216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15067004}. Nucleus {ECO:0000269|PubMed:15067004}.
uniprot
proteins