GPI
entrez
2821
canonical
uniprot
P06744
canonical
ensembl
ENSG00000105220
resolver
ensp
ENSP00000348877
resolver
ensp
ENSP00000405573
resolver
ensp
ENSP00000465858
resolver
ensp
ENSP00000467670
resolver
ensp
ENSP00000591342
resolver
enst
ENST00000415930
resolver
genesymbol
GPI
resolver
hgnc
HGNC:4458
resolver
uniprot
A0A2U3TZU2
resolver
uniprot
B4DE36
resolver
uniprot
B4DG39
resolver
uniprot
Q9BRD3
resolver
uniprot
Q9BSK5
resolver
uniprot
Q9UHE6
resolver
uniprot_entry
A0A2U3TZU2_HUMAN
resolver
uniprot_entry
B4DE36_HUMAN
resolver
uniprot_entry
G6PI_HUMAN
resolver
uniprot_sec
B4DG39
resolver
uniprot_sec
Q9BRD3
resolver
uniprot_sec
Q9BSK5
resolver
uniprot_sec
Q9UHE6
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by erythrose 4-phosphate. {ECO:0000269|PubMed:12054796}.
uniprot
proteins
amino_acid_sequence
MAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPRVWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTTKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSAQVTSHDASTNGLINFIKQQREARVQ
uniprot
proteins
disease_involvement
DISEASE: Anemia, congenital, non-spherocytic hemolytic, 4 (CNSHA4) [MIM:613470]: An autosomal recessive form of anemia in which there is no abnormal hemoglobin or spherocytosis. It is caused by glucose phosphate isomerase deficiency. {ECO:0000269|PubMed:28803808, ECO:0000269|PubMed:7989588, ECO:0000269|PubMed:8499925, ECO:0000269|PubMed:8822952, ECO:0000269|PubMed:8822954, ECO:0000269|PubMed:9446754, ECO:0000269|PubMed:9856489}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
5.1.3.-
uniprot
proteins
ec_number
5.3.1.9
uniprot
proteins
function
FUNCTION: Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm (PubMed:28803808). Also shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) and D-mannose-6-phosphate (M6P) (By similarity). Also displays anomerase activity, interconverting alpha and beta-anomeric forms of G6P, D-fructose-6-phosphate and M6P (By similarity). In addition to its metabolic role, this enzyme functions extracellularly as a cytokine: acts as autocrine motility factor (AMF), a secreted angiogenic factor that enhances endothelial cell motility (PubMed:11437381). Functions as neuroleukin, a neurotrophic factor supporting the survival of spinal and sensory neurons (PubMed:11004567, PubMed:3352745). Released by lectin-stimulated T-cells to induce immunoglobulin secretion (PubMed:11004567, PubMed:3352745). {ECO:0000250|UniProtKB:P12709, ECO:0000250|UniProtKB:Q9N1E2, ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381, ECO:0000269|PubMed:28803808, ECO:0000269|PubMed:3352745}.
uniprot
proteins
mass_dalton
63147
uniprot
proteins
mutagenesis
MUTAGEN 185; /note="S->A: Retained full enzymatic activity."; /evidence="ECO:0000269|PubMed:15637053"; MUTAGEN 185; /note="S->E: Decreased enzymatic activity."; /evidence="ECO:0000269|PubMed:15637053
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. {ECO:0000269|PubMed:28803808}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway. {ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:15637053}.; PTM: ISGylated. {ECO:0000269|PubMed:16139798}.
uniprot
proteins
protein_family
GPI family
uniprot
proteins
pubmed
10727272
uniprot
proteins
pubmed
11004567
uniprot
proteins
pubmed
11371164
uniprot
proteins
pubmed
11437381
uniprot
proteins
pubmed
12054796
uniprot
proteins
pubmed
12163179
uniprot
proteins
pubmed
12573240
uniprot
proteins
pubmed
12777791
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15637053
uniprot
proteins
pubmed
16139798
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21908771
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2387591
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28803808
uniprot
proteins
pubmed
29775581
uniprot
proteins
pubmed
3352745
uniprot
proteins
pubmed
7989588
uniprot
proteins
pubmed
8499925
uniprot
proteins
pubmed
8822952
uniprot
proteins
pubmed
8822954
uniprot
proteins
pubmed
9446754
uniprot
proteins
pubmed
9856489
uniprot
proteins
sequence_length
558
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11437381}. Secreted {ECO:0000269|PubMed:11437381}.
uniprot
proteins