Myd88
entrez
17874
canonical
uniprot
P22366
canonical
ensembl
ENSMUSG00000032508
resolver
ensp
ENSMUSP00000035092
resolver
genesymbol
Myd88
resolver
uniprot
O35916
resolver
uniprot
Q3U7M4
resolver
uniprot_entry
MYD88_MOUSE
resolver
uniprot_entry
Q3U7M4_MOUSE
resolver
uniprot_sec
O35916
resolver
amino_acid_sequence
MSAGDPRVGSGSLDSFMFSIPLVALNVGVRRRLSLFLNPRTPVAADWTLLAEEMGFEYLEIRELETRPDPTRSLLDAWQGRSGASVGRLLELLALLDREDILKELKSRIEEDCQKYLGKQQNQESEKPLQVARVESSVPQTKELGGITTLDDPLGQTPELFDAFICYCPNDIEFVQEMIRQLEQTDYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGVQQKRLIPIKYKAMKKDFPSILRFITICDYTNPCTKSWFWTRLAKALSLP
uniprot
proteins
function
FUNCTION: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:9697844). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9575168, PubMed:9697844). Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway (PubMed:9697844). Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (PubMed:17018642). Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (PubMed:17635956, PubMed:21998396). Mediates leukocyte recruitment at the inflammatory site (PubMed:18941239). {ECO:0000250|UniProtKB:Q99836, ECO:0000269|PubMed:11909531, ECO:0000269|PubMed:17018642, ECO:0000269|PubMed:17635956, ECO:0000269|PubMed:18941239, ECO:0000269|PubMed:21998396, ECO:0000269|PubMed:9575168, ECO:0000269|PubMed:9697844}.; FUNCTION: [Isoform 2]: Defective in its ability to induce IRAK phosphorylation and NF-kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS). {ECO:0000269|PubMed:11909531}.
uniprot
proteins
mass_dalton
33753
uniprot
proteins
mutagenesis
MUTAGEN 56; /note="F->N: Prevents dimerization of death domains and activation of JNK and NF-kappa-B."; /evidence="ECO:0000269|PubMed:9575168
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88. Deubiquitinated by USP3 that cleaves 'Lys-63'-linked ubiquitin chains leading to inhibition of MYD88-induced NF-kappa-B signaling. Ubiquitinated by the complex made of the adapter SMAD6 and the E3 ligase SMURF1, leading to proteasomal degradation (PubMed:21897371). {ECO:0000250|UniProtKB:Q99836, ECO:0000269|PubMed:21897371}.
uniprot
proteins
pubmed
11909531
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16951688
uniprot
proteins
pubmed
17018642
uniprot
proteins
pubmed
17635956
uniprot
proteins
pubmed
18941239
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21897371
uniprot
proteins
pubmed
21998396
uniprot
proteins
pubmed
22187460
uniprot
proteins
pubmed
2374694
uniprot
proteins
pubmed
29395066
uniprot
proteins
pubmed
9013863
uniprot
proteins
pubmed
9344657
uniprot
proteins
pubmed
9575168
uniprot
proteins
pubmed
9697844
uniprot
proteins
sequence_length
296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17018642, ECO:0000269|PubMed:21897371}. Nucleus {ECO:0000250|UniProtKB:Q99836}.
uniprot
proteins