Fgg
entrez
99571
canonical
uniprot
Q8VCM7
canonical
ensembl
ENSMUSG00000033860
resolver
ensp
ENSMUSP00000037018
resolver
ensp
ENSMUSP00000141648
resolver
enst
ENSMUST00000048486
resolver
enst
ENSMUST00000194175
resolver
genesymbol
Fgg
resolver
uniprot
A0A0A6YWQ6
resolver
uniprot
Q3UEM7
resolver
uniprot
Q3UER8
resolver
uniprot
Q8WUR3
resolver
uniprot
Q91ZP0
resolver
uniprot_entry
A0A0A6YWQ6_MOUSE
resolver
uniprot_entry
FIBG_MOUSE
resolver
uniprot_entry
Q3UEM7_MOUSE
resolver
uniprot_entry
Q3UER8_MOUSE
resolver
uniprot_sec
Q8WUR3
resolver
uniprot_sec
Q91ZP0
resolver
amino_acid_sequence
MSWSLQPPSFLLCCLLLLFSPTGLAYVATRDNCCILDERFGSFCPTTCGIADFLSSYQTDVDNDLRTLEDILFRAENRTTEAKELIKAIQVYYNPDQPPKPGMIDSATQKSKKMVEEIVKYEALLLTHETSIRYLQEIYNSNNQKITNLKQKVAQLEAQCQEPCKDSVQIHDTTGKDCQEIANKGAKESGLYFIRPLKAKQQFLVYCEIDGSGNGWTVLQKRIDGSLDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISMQSTIPYALRIQLKDWNGRTSTADYAMFRVGPESDKYRLTYAYFIGGDAGDAFDGYDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYHQGGTYSKSSTTNGFDDGIIWATWKSRWYSMKETTMKIIPFNRLSIGEGQQHHMGGSKQAGDV
uniprot
proteins
function
FUNCTION: Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix (By similarity). Fibrin has a major function in hemostasis as one of the primary components of blood clots (By similarity). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (By similarity). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (By similarity). Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway (PubMed:19332769). Maternal fibrinogen is essential for successful pregnancy (By similarity). Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (By similarity). May also facilitate the immune response via both innate and T-cell mediated pathways (By similarity). {ECO:0000250|UniProtKB:E9PV24, ECO:0000269|PubMed:19332769}.
uniprot
proteins
mass_dalton
49391
uniprot
proteins
mutagenesis
MUTAGEN 432..436; /note="Missing: Impairs induction of SELP in activated platelets."; /evidence="ECO:0000269|PubMed:19332769
uniprot
proteins
post_translational_modification
PTM: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19332769
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
436
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02679}.
uniprot
proteins