Gck
entrez
103988
canonical
uniprot
P52792
canonical
ensembl
ENSMUSG00000041798
resolver
ensp
ENSMUSP00000099984
resolver
ensp
ENSMUSP00000105448
resolver
genesymbol
Gck
resolver
genesymbol_syn
Gk
resolver
uniprot
P52791
resolver
uniprot
Q5SVI5
resolver
uniprot
Q5SVI6
resolver
uniprot_entry
HXK4_MOUSE
resolver
uniprot_entry
Q5SVI5_MOUSE
resolver
uniprot_entry
Q5SVI6_MOUSE
resolver
uniprot_sec
P52791
resolver
activity_regulation
ACTIVITY REGULATION: Subject to allosteric regulation. Low glucose and high fructose-6-phosphate triggers association with the inhibitor GCKR followed by sequestration in the nucleus. {ECO:0000250|UniProtKB:P35557}.
uniprot
proteins
amino_acid_sequence
MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLKLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGNSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVEENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRRQILNILSTLGLRPSVADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ
uniprot
proteins
ec_number
2.7.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively) (PubMed:8530440). Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity). Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues (PubMed:8530440, PubMed:9867845). Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change its enzymatic activity within the physiological range of glucose concentrations, GCK acts as a glucose sensor in the pancreatic beta cell (PubMed:8530440, PubMed:9867845). In pancreas, plays an important role in modulating insulin secretion (PubMed:8530440). In liver, helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (PubMed:9867845). Required to provide D-glucose 6-phosphate for the synthesis of glycogen (PubMed:9867845). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). {ECO:0000250|UniProtKB:P17712, ECO:0000250|UniProtKB:P35557, ECO:0000269|PubMed:8530440, ECO:0000269|PubMed:9867845}.
uniprot
proteins
mass_dalton
52089
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate metabolism; hexose metabolism. {ECO:0000305|PubMed:8530440}.; PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4. {ECO:0000305|PubMed:8530440}.
uniprot
proteins
protein_family
Hexokinase family
uniprot
proteins
pubmed
10713097
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1999433
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21987372
uniprot
proteins
pubmed
24187134
uniprot
proteins
pubmed
7665557
uniprot
proteins
pubmed
8530440
uniprot
proteins
pubmed
8575768
uniprot
proteins
pubmed
8575769
uniprot
proteins
pubmed
9867845
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24187134}. Nucleus {ECO:0000269|PubMed:10713097}. Mitochondrion {ECO:0000250|UniProtKB:P17712}. Note=Under low glucose concentrations, GCK associates with GCKR and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000269|PubMed:10713097}.
uniprot
proteins