Cops4
entrez
360915
canonical
uniprot
Q68FS2
canonical
ensembl
ENSRNOG00000023650
resolver
ensembl
ENSRNOG00055006176
resolver
ensembl
ENSRNOG00060010449
resolver
ensembl
ENSRNOG00065012569
resolver
ensp
ENSRNOP00000003046
resolver
ensp
ENSRNOP00055007731
resolver
ensp
ENSRNOP00060013727
resolver
ensp
ENSRNOP00065015697
resolver
enst
ENSRNOT00000003046
resolver
enst
ENSRNOT00055010006
resolver
enst
ENSRNOT00060017665
resolver
enst
ENSRNOT00065020434
resolver
genesymbol
Cops4
resolver
genesymbol_syn
Csn4
resolver
uniprot_entry
CSN4_RAT
resolver
amino_acid_sequence
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGTEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEVYHFTLEKVQPRVISFEEQVASIRQRLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ
uniprot
proteins
function
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). {ECO:0000250|UniProtKB:Q9BT78}.
uniprot
proteins
mass_dalton
46290
uniprot
proteins
protein_family
CSN4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21102408
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BT78}. Nucleus {ECO:0000250|UniProtKB:Q9BT78}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:21102408}.
uniprot
proteins