JADE1
entrez
79960
canonical
uniprot
Q6IE81
canonical
ensembl
ENSG00000077684
resolver
ensp
ENSP00000226319
resolver
ensp
ENSP00000388015
resolver
ensp
ENSP00000404211
resolver
ensp
ENSP00000423737
resolver
ensp
ENSP00000425730
resolver
ensp
ENSP00000482212
resolver
ensp
ENSP00000483219
resolver
ensp
ENSP00000557662
resolver
ensp
ENSP00000557664
resolver
ensp
ENSP00000791285
resolver
ensp
ENSP00000795496
resolver
ensp
ENSP00000795497
resolver
genesymbol
JADE1
resolver
genesymbol_syn
KIAA1807
resolver
genesymbol_syn
PHF17
resolver
hgnc
HGNC:30027
resolver
uniprot
B4E2E2
resolver
uniprot
D3DNY0
resolver
uniprot
D3DNY1
resolver
uniprot
Q4W5D5
resolver
uniprot
Q6ZSL7
resolver
uniprot
Q8NC41
resolver
uniprot
Q96JL8
resolver
uniprot
Q96SQ1
resolver
uniprot
Q9H692
resolver
uniprot_entry
B4E2E2_HUMAN
resolver
uniprot_entry
JADE1_HUMAN
resolver
uniprot_sec
D3DNY0
resolver
uniprot_sec
D3DNY1
resolver
uniprot_sec
Q4W5D5
resolver
uniprot_sec
Q6ZSL7
resolver
uniprot_sec
Q8NC41
resolver
uniprot_sec
Q96JL8
resolver
uniprot_sec
Q96SQ1
resolver
uniprot_sec
Q9H692
resolver
amino_acid_sequence
MKRGRLPSSSEDSDDNGSLSTTWSQNSRSQHRRSSCSRHEDRKPSEVFRTDLITAMKLHDSYQLNPDEYYVLADPWRQEWEKGVQVPVSPGTIPQPVARVVSEEKSLMFIRPKKYIVSSGSEPPELGYVDIRTLADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYCPKHSSHRKPEESLGKGAAQENGAPECSPRNPLEPFASLEQNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFNLYTKLLEQERVSGVPSSCSSSSLENMLLFNSPSVGPDAPKIEDLKWHSAFFRKQMGTSLVHSLKKPHKRDPLQNSPGSEGKTLLKQPDLCGRREGMVVPESFLGLEKTFAEARLISAQQKNGVVMPDHGKRRDNRFHCDLIKGDLKDKSFKQSHKPLRSTDVSQRHLDNTRAATSPGVGQSAPGTRKEIVPKCNGSLIKVNYNQTAVKVPTTPASPVKNWGGFRIPKKGERQQQGEAHDGACHQHSDYPYLGLGRVPAKERAKSKLKSDNENDGYVPDVEMSDSESEASEKKCIHTSSTISRRTDIIRRSILAS
uniprot
proteins
function
FUNCTION: Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112). {ECO:0000269|PubMed:15502158, ECO:0000269|PubMed:16046545, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22654112, ECO:0000269|PubMed:24065767}.
uniprot
proteins
mass_dalton
95533
uniprot
proteins
protein_family
JADE family
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
12169691
uniprot
proteins
pubmed
14612400
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15502158
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16046545
uniprot
proteins
pubmed
16387653
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
19187766
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20129055
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22654112
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24065767
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29382722
uniprot
proteins
sequence_length
842
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15502158, ECO:0000269|PubMed:22654112}. Chromosome {ECO:0000269|PubMed:19187766}. Cytoplasm {ECO:0000269|PubMed:12169691, ECO:0000269|PubMed:15502158}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22654112}. Note=Localizes to the ciliary transition zone. {ECO:0000269|PubMed:22654112}.
uniprot
proteins