SEC24C
entrez
9632
canonical
uniprot
P53992
canonical
ensembl
ENSG00000176986
resolver
ensp
ENSP00000321845
resolver
ensp
ENSP00000343405
resolver
ensp
ENSP00000564029
resolver
ensp
ENSP00000609980
resolver
genesymbol
SEC24C
resolver
genesymbol_syn
KIAA0079
resolver
hgnc
HGNC:10705
resolver
uniprot
B4DZT4
resolver
uniprot
Q8WV25
resolver
uniprot_entry
SC24C_HUMAN
resolver
uniprot_sec
B4DZT4
resolver
uniprot_sec
Q8WV25
resolver
amino_acid_sequence
MNVNQSVPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSFGPARGPQSNYGGPYPAAPTFGSQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNRGTEPFVTGVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPFMQFIEGGRRFQCCFCSCINDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDFLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVADMFVPLLDGFLVNVNESRAVITSLLDQIPEMFADTRETETVFVPVIQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQTGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQVENDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEESGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRGVLNSPVKAVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEVTTDDRAYVRQLVTSMDVTETNVFFYPRLLPLTKSPVESTTEPPAVRASEERLSNGDIYLLENGLNLFLWVGASVQQGVVQSLFSVSSFSQITSGLSVLPVLDNPLSKKVRGLIDSLRAQRSRYMKLTVVKQEDKMEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQLLS
uniprot
proteins
function
FUNCTION: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317, PubMed:41887218). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317, PubMed:41887218). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317, PubMed:41887218). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:10214955, ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}.
uniprot
proteins
mass_dalton
118325
uniprot
proteins
mutagenesis
MUTAGEN 840; /note="R->D: Reduced STING1 endoplasmic reticulum exit."; /evidence="ECO:0000269|PubMed:41887218"; MUTAGEN 888; /note="S->E: Reduced STING1 endoplasmic reticulum exit."; /evidence="ECO:0000269|PubMed:41887218"; MUTAGEN 895..897; /note="LIL->AAA: Loss of packaging into COPII-coated vesicles of the IxM motif-containing cargos GOSR2 and STX5."; /evidence="ECO:0000269|PubMed:18843296"; MUTAGEN 896; /note="I->E: Reduced STING1 endoplasmic reticulum exit."; /evidence="ECO:0000269|PubMed:41887218
uniprot
proteins
protein_family
SEC23/SEC24 family
uniprot
proteins
protein_family
SEC24 subfamily
uniprot
proteins
pubmed
10075675
uniprot
proteins
pubmed
10214955
uniprot
proteins
pubmed
10329445
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17428803
uniprot
proteins
pubmed
17499046
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18843296
uniprot
proteins
pubmed
20427317
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30842662
uniprot
proteins
pubmed
41887218
uniprot
proteins
pubmed
7584044
uniprot
proteins
sequence_length
1094
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:10075675, ECO:0000269|PubMed:10329445}; Peripheral membrane protein {ECO:0000269|PubMed:10075675}; Cytoplasmic side {ECO:0000269|PubMed:10075675}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10075675, ECO:0000269|PubMed:10329445}; Peripheral membrane protein {ECO:0000269|PubMed:10075675}; Cytoplasmic side {ECO:0000269|PubMed:10075675}. Cytoplasm, cytosol {ECO:0000269|PubMed:10075675}.
uniprot
proteins