HMHA1
entrez
23526
canonical
uniprot
Q92619
canonical
ensembl
ENSG00000180448
resolver
ensp
ENSP00000316772
resolver
ensp
ENSP00000438979
resolver
ensp
ENSP00000439601
resolver
ensp
ENSP00000468607
resolver
ensp
ENSP00000468615
resolver
ensp
ENSP00000555719
resolver
enst
ENST00000543365
resolver
enst
ENST00000586866
resolver
enst
ENST00000590577
resolver
genesymbol
ARHGAP45
resolver
genesymbol
HMHA1
resolver
genesymbol_syn
HMHA1
resolver
genesymbol_syn
KIAA0223
resolver
hgnc
HGNC:17102
resolver
uniprot
B3KVA9
resolver
uniprot
B3KXW7
resolver
uniprot
B4DTS4
resolver
uniprot
F5H1R4
resolver
uniprot
F6QP70
resolver
uniprot
K7ES92
resolver
uniprot
K7ES98
resolver
uniprot
Q6P189
resolver
uniprot
Q7LE26
resolver
uniprot
Q86WS1
resolver
uniprot
Q8HX84
resolver
uniprot
Q8IYN3
resolver
uniprot
Q9GJN9
resolver
uniprot
Q9GJP0
resolver
uniprot
Q9GJP1
resolver
uniprot
Q9MY24
resolver
uniprot_entry
B3KVA9_HUMAN
resolver
uniprot_entry
B3KXW7_HUMAN
resolver
uniprot_entry
F5H1R4_HUMAN
resolver
uniprot_entry
HMHA1_HUMAN
resolver
uniprot_entry
K7ES92_HUMAN
resolver
uniprot_entry
K7ES98_HUMAN
resolver
uniprot_entry
Q8IYN3_HUMAN
resolver
uniprot_sec
B4DTS4
resolver
uniprot_sec
F6QP70
resolver
uniprot_sec
Q6P189
resolver
uniprot_sec
Q7LE26
resolver
uniprot_sec
Q86WS1
resolver
uniprot_sec
Q8HX84
resolver
uniprot_sec
Q9GJN9
resolver
uniprot_sec
Q9GJP0
resolver
uniprot_sec
Q9GJP1
resolver
uniprot_sec
Q9MY24
resolver
amino_acid_sequence
MFSRKKRELMKTPSISKKNRAGSPSPQPSGELPRKDGADAVFPGPSLEPPAGSSGVKATGTLKRPTSLSRHASAAGFPLSGAASWTLGRSHRSPLTAASPGELPTEGAGPDVVEDISHLLADVARFAEGLEKLKECVLRDDLLEARRPRAHECLGEALRVMHQIISKYPLLNTVETLTAAGTLIAKVKAFHYESNNDLEKQEFEKALETIAVAFSSTVSEFLMGEVDSSTLLAVPPGDSSQSMESLYGPGSEGTPPSLEDCDAGCLPAEEVDVLLQRCEGGVDAALLYAKNMAKYMKDLISYLEKRTTLEMEFAKGLQKIAHNCRQSVMQEPHMPLLSIYSLALEQDLEFGHSMVQAVGTLQTQTFMQPLTLRRLEHEKRRKEIKEAWHRAQRKLQEAESNLRKAKQGYVQRCEDHDKARFLVAKAEEEQAGSAPGAGSTATKTLDKRRRLEEEAKNKAEEAMATYRTCVADAKTQKQELEDTKVTALRQIQEVIRQSDQTIKSATISYYQMMHMQTAPLPVHFQMLCESSKLYDPGQQYASHVRQLQRDQEPDVHYDFEPHVSANAWSPVMRARKSSFNVSDVARPEAAGSPPEEGGCTEGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEELVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQCGHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAADGCRESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEATAREDGDGDEDGPAQQLSGFNTNQSNNVLQAPLPPMRLRGGRMTLGSCRERQPEFV
uniprot
proteins
function
FUNCTION: Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}.
uniprot
proteins
mass_dalton
124614
uniprot
proteins
pubmed
10958358
uniprot
proteins
pubmed
11095984
uniprot
proteins
pubmed
11965046
uniprot
proteins
pubmed
12601144
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16202172
uniprot
proteins
pubmed
16399573
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24086303
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8260714
uniprot
proteins
pubmed
8532022
uniprot
proteins
pubmed
8843592
uniprot
proteins
pubmed
9039502
uniprot
proteins
pubmed
9461441
uniprot
proteins
pubmed
9798702
uniprot
proteins
pubmed
9820595
uniprot
proteins
sequence_length
1136
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24086303}. Cell projection, ruffle membrane {ECO:0000269|PubMed:24086303}.
uniprot
proteins