Gpr12
entrez
80840
canonical
uniprot
P30951
canonical
ensembl
ENSRNOG00000039832
resolver
ensp
ENSRNOP00000057844
resolver
ensp
ENSRNOP00000075912
resolver
ensp
ENSRNOP00000109414
resolver
ensp
ENSRNOP00000110897
resolver
ensp
ENSRNOP00000112843
resolver
enst
ENSRNOT00000061129
resolver
enst
ENSRNOT00000092720
resolver
enst
ENSRNOT00000121921
resolver
enst
ENSRNOT00000142733
resolver
enst
ENSRNOT00000154216
resolver
genesymbol
Gpr12
resolver
genesymbol_syn
Gpcr12
resolver
uniprot
A0JPJ1
resolver
uniprot_entry
GPR12_RAT
resolver
uniprot_sec
A0JPJ1
resolver
amino_acid_sequence
MNEDPKVNLSGLPRDCIEAGTPENISAAVPSQGSVVESEPELVVNPWDIVLCSSGTLICCENAVVVLIIFHSPSLRAPMFLLIGSLALADLLAGLGLIINFVFAYLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSTCLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSISFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGISTLALILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPNTLSQRARSPSDV
uniprot
proteins
function
FUNCTION: Brain-specific G protein-coupled receptor involved in regulating diverse physiological processes including neurite outgrowth, meiotic arrest, and lipid and carbohydrate metabolism (PubMed:17284443). Functions as a receptor with constitutive G(s)-mediated signaling activity that stimulates cyclic AMP (cAMP) production. Also engages the G(i)/G(o) pathway, which counteracts the cAMP increase driven by G(s) activation. Additionally, two lipids sphingosylphosphorylcholine (SPC) and sphingosine-1-phosphate (S1P) may act as endogenous ligand and activate GPR12 (By similarity). {ECO:0000250|UniProtKB:P35412, ECO:0000250|UniProtKB:P47775, ECO:0000269|PubMed:17284443}.
uniprot
proteins
mass_dalton
36704
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17284443
uniprot
proteins
pubmed
1840531
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..71; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P47775"; TRANSMEM 78..103; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P47775"; TRANSMEM 114..136; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P47775"; TRANSMEM 154..176; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P47775"; TRANSMEM 193..217; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P47775"; TRANSMEM 252..274; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P47775"; TRANSMEM 281..303; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P47775
uniprot
proteins