TNFRSF9
entrez
3604
canonical
uniprot
Q07011
canonical
ensembl
ENSG00000049249
resolver
ensp
ENSP00000366729
resolver
ensp
ENSP00000545651
resolver
enst
ENST00000377507
resolver
enst
ENST00000875592
resolver
genesymbol
TNFRSF9
resolver
genesymbol_syn
CD137
resolver
genesymbol_syn
ILA
resolver
hgnc
HGNC:11924
resolver
uniprot_entry
TNR9_HUMAN
resolver
amino_acid_sequence
MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 109 with lymphoproliferation (IMD109) [MIM:620282]: An autosomal recessive primary immune disorder characterized by recurrent sinopulmonary infections, susceptibility to infection with Epstein-Barr virus (EBV), persistent EBV viremia, and EBV-induced lymphoproliferation or B-cell lymphoma. {ECO:0000269|PubMed:30872117}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable). {ECO:0000305|PubMed:30872117}.
uniprot
proteins
mass_dalton
27899
uniprot
proteins
pubmed
11804328
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
30872117
uniprot
proteins
pubmed
7622190
uniprot
proteins
pubmed
8088337
uniprot
proteins
pubmed
8262389
uniprot
proteins
pubmed
9418902
uniprot
proteins
pubmed
9607925
uniprot
proteins
sequence_length
255
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein {ECO:0000305|PubMed:30872117}.
uniprot
proteins
transmembrane_region
TRANSMEM 187..213; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins