Arid5a
entrez
214855
canonical
uniprot
Q3U108
canonical
ensembl
ENSMUSG00000037447
resolver
ensp
ENSMUSP00000095385
resolver
ensp
ENSMUSP00000110681
resolver
ensp
ENSMUSP00000110683
resolver
ensp
ENSMUSP00000110684
resolver
ensp
ENSMUSP00000117810
resolver
enst
ENSMUST00000097778
resolver
genesymbol
Arid5a
resolver
uniprot
D3Z0W0
resolver
uniprot
Q3TZS4
resolver
uniprot
Q3U0F0
resolver
uniprot
Q3U0S2
resolver
uniprot
Q3UDA3
resolver
uniprot
Q3UDZ6
resolver
uniprot
Q8BI45
resolver
uniprot
Q8BYB5
resolver
uniprot
Q8R2W1
resolver
uniprot_entry
ARI5A_MOUSE
resolver
uniprot_entry
D3Z0W0_MOUSE
resolver
uniprot_sec
Q3TZS4
resolver
uniprot_sec
Q3U0F0
resolver
uniprot_sec
Q3U0S2
resolver
uniprot_sec
Q3UDA3
resolver
uniprot_sec
Q3UDZ6
resolver
uniprot_sec
Q8BI45
resolver
uniprot_sec
Q8BYB5
resolver
uniprot_sec
Q8R2W1
resolver
amino_acid_sequence
MAAPPAKGNTEQSEEGDLPQLPVSPKPDDEQSRSQSPTQLQDSPEAGGEQEEEQAFLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVEKLGAYELVTGRRLWKNVYDELGGSPGSTSAATCTRRHYERLVLPYVRHLKGEDDKPLPPTKPRKQYKMAKELRGDDGTTEKLKKAKDSEERRVEQTTPGKTKSDATGQTQLPCQGSSRDSTEQLGPVSGPSPPLTGASSCPEAYKRLLSSFYCKGAHGIMSPLAKKKLLAQVSKAEALQCQEEGCRHGARSPNKDIQDSPQNLRGPAENSEHQLTPREGLQAPGGSTRMEAQVGPCPTAPMFSGCFHAYPTEVLKPVSQHPRDFFSGLKDRVLLGPPGKEEGPTTKESHLVWGGDANHPSAFHKGSTRKRSFYPKPKACWVSPMAKVPTERPGAPSPHPSSPGLGSKRGLEEEGFAHGGKKLRAVSPFLKEVDSKETGGKPAAPGLAVSCLLGPTPGPTPPEAYRGTMLRCPLNFTGSADPLKGQASLPFSPLVIPAFPAHLLATTGSSPMAASLMHFPPTPYDAVLRNRLGPASSAWHMPPVTTYAAPHFFHLNTKL
uniprot
proteins
function
FUNCTION: DNA-binding protein that may regulate transcription and act as a repressor by binding to AT-rich stretches in the promoter region of target genes (By similarity). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (PubMed:21346191). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (By similarity). As an RNA-binding protein, involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as STAT3 and TBX21. Also stabilizes IL6 mRNA. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells (PubMed:23676272, PubMed:27022145). In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling (PubMed:24782182). Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (PubMed:27671645). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (PubMed:29244194). {ECO:0000250|UniProtKB:Q03989, ECO:0000269|PubMed:21346191, ECO:0000269|PubMed:23676272, ECO:0000269|PubMed:24782182, ECO:0000269|PubMed:27022145, ECO:0000269|PubMed:27671645, ECO:0000269|PubMed:29244194}.
uniprot
proteins
mass_dalton
63898
uniprot
proteins
mutagenesis
MUTAGEN 128; /note="R->A: Abolishes binding to STAT3 3'UTR stem loop structure. Abolishes binding to TNFRSF4/OX40 mRNA."; /evidence="ECO:0000269|PubMed:27022145, ECO:0000269|PubMed:29244194"; MUTAGEN 253; /note="S->A: Abolishes ubiquitination; largely impairs proteasomal degradation; results in overproduction of IL-6 upon overexpression; in association with A-433 and A-458."; /evidence="ECO:0000269|PubMed:28168301"; MUTAGEN 433; /note="S->A: Abolishes ubiquitination; largely impairs proteasomal degradation; results in overproduction of IL-6 upon overexpression; in association with A-253 and A-458."; /evidence="ECO:0000269|PubMed:28168301"; MUTAGEN 458; /note="S->A: Abolishes ubiquitination; largely impairs proteasomal degradation; results in overproduction of IL-6 upon overexpression; in association with A-253 and A-433."; /evidence="ECO:0000269|PubMed:28168301
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK14 on serine residues involving a TLR4 signaling pathway upon lipopolysaccharide (LPS) stimulation leading to its ubiquitination and proteasomal degradation. {ECO:0000269|PubMed:28168301}.; PTM: Ubiquitinated leading to proteasomal degradation; involving WWP1 linked to MAPK14-mediated phosphorylation upon LPS stimulation. {ECO:0000269|PubMed:28168301}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21346191
uniprot
proteins
pubmed
23676272
uniprot
proteins
pubmed
24782182
uniprot
proteins
pubmed
27022145
uniprot
proteins
pubmed
27671645
uniprot
proteins
pubmed
28168301
uniprot
proteins
pubmed
29244194
uniprot
proteins
sequence_length
590
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:21346191}.
uniprot
proteins