Lamtor1
entrez
308869
canonical
uniprot
Q6P791
canonical
ensembl
ENSRNOG00000004319
resolver
ensembl
ENSRNOG00000020016
resolver
ensembl
ENSRNOG00055028796
resolver
ensembl
ENSRNOG00060003179
resolver
ensembl
ENSRNOG00065022816
resolver
ensp
ENSRNOP00000089922
resolver
ensp
ENSRNOP00000104691
resolver
ensp
ENSRNOP00055041119
resolver
ensp
ENSRNOP00060003885
resolver
ensp
ENSRNOP00065031646
resolver
enst
ENSRNOT00000005702
resolver
enst
ENSRNOT00000157834
resolver
enst
ENSRNOT00055049928
resolver
enst
ENSRNOT00060005250
resolver
enst
ENSRNOT00065038989
resolver
genesymbol
Lamtor1
resolver
uniprot_entry
LTOR1_RAT
resolver
amino_acid_sequence
MGCCYSSENEDSDQDQEERKLLLDPSNTPTKALNGAEPSYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP
uniprot
proteins
function
FUNCTION: Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane. LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (By similarity). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation (By similarity). {ECO:0000250|UniProtKB:Q6IAA8, ECO:0000250|UniProtKB:Q9CQ22}.
uniprot
proteins
mass_dalton
17721
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Loss of localization to the late endosomes and redistribution to the cytoplasm."; /evidence="ECO:0000269|PubMed:19177150"; MUTAGEN 3..4; /note="CC->AA: Loss of localization to the late endosomes and redistribution to the cytoplasm."; /evidence="ECO:0000269|PubMed:19177150
uniprot
proteins
post_translational_modification
PTM: N-terminal myristoylation and palmitoylation mediates its recruitment to lysosome membranes, thereby promoting localization of the Ragulator complex to lysosomes. N-myristoylation by NMT1 is required for palmitoylation at Cys-3 and Cys-4. May be palmitoylated by ZDHHC3. {ECO:0000250|UniProtKB:Q6IAA8}.; PTM: Ubiquitinated at Lys-60, Lys-103 and Lys-104 by UBE3A, promoting its degradation by the proteasome. Ubiquitination at Lys-20 impairs the association with the lysosomal V-ATPase complex. Deubiquitination at Lys-20 by USP32 promotes the association with the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex. {ECO:0000250|UniProtKB:Q6IAA8}.
uniprot
proteins
protein_family
LAMTOR1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19177150
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
161
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q6IAA8}; Lipid-anchor {ECO:0000250|UniProtKB:Q6IAA8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q6IAA8}. Late endosome membrane {ECO:0000250|UniProtKB:Q6IAA8}; Lipid-anchor {ECO:0000250|UniProtKB:Q6IAA8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q6IAA8}. Note=Recruited to lysosome and endosome membranes through N-terminal myristoylation and palmitoylation. {ECO:0000250|UniProtKB:Q6IAA8}.
uniprot
proteins