PIP4K2A
entrez
5305
canonical
uniprot
P48426
canonical
ensembl
ENSG00000150867
resolver
ensp
ENSP00000365757
resolver
ensp
ENSP00000442098
resolver
ensp
ENSP00000569881
resolver
genesymbol
PIP4K2A
resolver
genesymbol_syn
PI5P4KA
resolver
genesymbol_syn
PIP5K2
resolver
genesymbol_syn
PIP5K2A
resolver
hgnc
HGNC:8997
resolver
uniprot
B0YJ66
resolver
uniprot
B4DGX2
resolver
uniprot
D3DRV1
resolver
uniprot
P53807
resolver
uniprot
Q5VUX3
resolver
uniprot_entry
PI42A_HUMAN
resolver
uniprot_sec
B0YJ66
resolver
uniprot_sec
B4DGX2
resolver
uniprot_sec
D3DRV1
resolver
uniprot_sec
P53807
resolver
uniprot_sec
Q5VUX3
resolver
activity_regulation
ACTIVITY REGULATION: In rod outer segments, activated by light. Inhibited by I-OMe tyrphostin AG-538 (I-OMe-AG-538), acting as an ATP-competitive inhibitor (PubMed:23326584). {ECO:0000250|UniProtKB:Q9R0I8, ECO:0000269|PubMed:23326584}.
uniprot
proteins
amino_acid_sequence
MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT
uniprot
proteins
ec_number
2.7.1.149
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:23326584, PubMed:9367159). Has both ATP- and GTP-dependent kinase activities (PubMed:26774281). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (PubMed:18364242). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (PubMed:29353240). In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:31091439). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism (PubMed:31091439). PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000250|UniProtKB:O70172, ECO:0000250|UniProtKB:Q9R0I8, ECO:0000269|PubMed:18364242, ECO:0000269|PubMed:23326584, ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:29353240, ECO:0000269|PubMed:31091439, ECO:0000269|PubMed:9367159}.
uniprot
proteins
mass_dalton
46225
uniprot
proteins
mutagenesis
MUTAGEN 131; /note="G->L: Abolishes catalytic activity; when associated with F-138."; /evidence="ECO:0000269|PubMed:20583997"; MUTAGEN 138; /note="Y->F: Abolishes catalytic activity; when associated with L-131."; /evidence="ECO:0000269|PubMed:20583997"; MUTAGEN 273; /note="D->K: Loss of kinase activity. Increases accumulation of lysosomal cholesterol."; /evidence="ECO:0000269|PubMed:29353240
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in tyrosines. Phosphorylation is induced by light and increases kinase activity. {ECO:0000250|UniProtKB:Q9R0I8}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18364242
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19896968
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20583997
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23326584
uniprot
proteins
pubmed
24081551
uniprot
proteins
pubmed
26774281
uniprot
proteins
pubmed
29353240
uniprot
proteins
pubmed
31091439
uniprot
proteins
pubmed
32130941
uniprot
proteins
pubmed
7639683
uniprot
proteins
pubmed
7852364
uniprot
proteins
pubmed
9367159
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O70172}. Nucleus {ECO:0000269|PubMed:20583997}. Lysosome {ECO:0000250|UniProtKB:O70172}. Cytoplasm {ECO:0000269|PubMed:20583997}. Photoreceptor inner segment {ECO:0000250|UniProtKB:O70172}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:O70172}. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B. {ECO:0000250|UniProtKB:O70172, ECO:0000269|PubMed:20583997}.
uniprot
proteins