Adra2c
entrez
24175
canonical
uniprot
P22086
canonical
ensembl
ENSRNOG00000084818
resolver
ensembl
ENSRNOG00055017127
resolver
ensembl
ENSRNOG00060024662
resolver
ensembl
ENSRNOG00065032982
resolver
ensp
ENSRNOP00000108688
resolver
ensp
ENSRNOP00055023393
resolver
ensp
ENSRNOP00060035335
resolver
ensp
ENSRNOP00065046727
resolver
enst
ENSRNOT00000156401
resolver
enst
ENSRNOT00055029058
resolver
enst
ENSRNOT00060042655
resolver
enst
ENSRNOT00065056748
resolver
genesymbol
Adra2c
resolver
uniprot_entry
ADA2C_RAT
resolver
amino_acid_sequence
MASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWGPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRGPAGPDGASPTTENGLGKAAGENGHCAPPRTEVEPDESSAAERRRRRGALRRGGRRREGAEGDTGSADGPGPGLAAEQGARTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
uniprot
proteins
function
FUNCTION: Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed:15213003). ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity (By similarity). {ECO:0000250|UniProtKB:Q01337, ECO:0000269|PubMed:15213003}.
uniprot
proteins
mass_dalton
49864
uniprot
proteins
protein_family
ADRA2C sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15213003
uniprot
proteins
pubmed
1645350
uniprot
proteins
pubmed
1704126
uniprot
proteins
pubmed
1704314
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18825}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..74; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P18825"; TRANSMEM 88..110; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P18825"; TRANSMEM 122..147; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P18825"; TRANSMEM 168..187; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P18825"; TRANSMEM 209..231; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P18825"; TRANSMEM 380..404; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P18825"; TRANSMEM 413..436; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P18825
uniprot
proteins