Nfasc
entrez
116690
canonical
uniprot
P97685
canonical
ensembl
ENSRNOG00000030515
resolver
ensp
ENSRNOP00000057594
resolver
ensp
ENSRNOP00000091013
resolver
ensp
ENSRNOP00000095471
resolver
ensp
ENSRNOP00000106961
resolver
enst
ENSRNOT00000110535
resolver
enst
ENSRNOT00000159596
resolver
genesymbol
Nfasc
resolver
uniprot
A0A8I6GIP5
resolver
uniprot
A0ABK0LY66
resolver
uniprot
P97684
resolver
uniprot
Q91Z60
resolver
uniprot_entry
A0A8I6GIP5_RAT
resolver
uniprot_entry
A0ABK0LY66_RAT
resolver
uniprot_entry
NFASC_RAT
resolver
uniprot_sec
P97684
resolver
uniprot_sec
Q91Z60
resolver
amino_acid_sequence
MARQQAPPWVHVALILFLLSLGGAIEIPMDPSIQNELTQPPTITKQSVKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTSSSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWLVNGDPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAKRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCMASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDDNNSPITDYVVQFEEDQFQPGVWHDHSKFPGSVNSAVLHLSPYVNYQFRVIAVNEVGSSHPSLPSERYRTSGAPPESNPSDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETRETWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPETVIGYSGEDLPSAPRRFRVRQPNLETINLEWDHPEHPNGILIGYTLRYVPFNGTKLGKQMVENFSPNQTKFSVQRADPVSRYRFSLSARTQVGSGEAATEESPTPPNEATPTAAPPTLPPTTVGTTGLVSSTDATALAATSEATTVPIIPTVVPTTVATTIATTTTTTAAATTTTTTESPPTTTTGTKIHETAPDEQSIWNVTVLPNSKWANITWKHNFRPGTDFVVEYIDSNHTKKTVPVKAQAQPIQLTDLFPGMTYTLRVYSRDNEGISSTVITFMTSTAYTNNQTDIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTVRKDKEETEGNESSEATSPVNAIYSLA
uniprot
proteins
function
FUNCTION: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. Isoform 2/isoform 3 may be responsible for mediating and signaling axon-glial interaction during the early stages of myelination. {ECO:0000269|PubMed:10931875, ECO:0000269|PubMed:16039564, ECO:0000269|PubMed:9562181}.
uniprot
proteins
mass_dalton
138004
uniprot
proteins
post_translational_modification
PTM: Isoform 2/isoform 3 is phosphorylated at P12. Dephosphorylation is required for ankyrin binding. {ECO:0000269|PubMed:10931875}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
L1/neurofascin/NgCAM family
uniprot
proteins
pubmed
10931875
uniprot
proteins
pubmed
11470829
uniprot
proteins
pubmed
16039564
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
8947556
uniprot
proteins
pubmed
9562181
uniprot
proteins
sequence_length
1240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 colocalizes with ankyrin G at the nodes of Ranvier. Isoform 2/ isoform 3 is a glial component of the paranodal axo-glial junction.
uniprot
proteins
transmembrane_region
TRANSMEM 1111..1131; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins