Prrt2
entrez
69017
canonical
uniprot
E9PUL5
canonical
ensembl
ENSMUSG00000045114
resolver
ensp
ENSMUSP00000124520
resolver
ensp
ENSMUSP00000186392
resolver
ensp
ENSMUSP00000186395
resolver
ensp
ENSMUSP00000360530
resolver
enst
ENSMUST00000159916
resolver
genesymbol
Prrt2
resolver
uniprot_entry
PRRT2_MOUSE
resolver
amino_acid_sequence
MAASSSQVSEMKGVEDSSKTQTEGPRHSEEGLGPVQVVAEIPDQPEALQPGPGITAAPVDSGPKAELAPETTETPVETPETVQATDLSLNPEEGSKASPSPSPSEARQEPASKPDVNRETAAEEGSEPQSTAPPEPTSEPAFQINTQSDPQPTSQPPPKPPLQAEPPTQEDPTTEVLTESTGEKQENGAVVPLQAGDGEEGPAPQPHSPPSTKTPPANGAPPRVLQKLVEEDRIGRAHGGHPGSPRGSLSRHPSSQLAGPGVEGGEGTQKPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIASCVINLGVYK
uniprot
proteins
function
FUNCTION: As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing (PubMed:27052163). In the cerebellum, may inhibit SNARE complex formation and down-regulate short-term facilitation (PubMed:29056747). {ECO:0000269|PubMed:27052163, ECO:0000269|PubMed:29056747}.
uniprot
proteins
mass_dalton
35924
uniprot
proteins
protein_family
CD225/Dispanin family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22101681
uniprot
proteins
pubmed
22243967
uniprot
proteins
pubmed
22363774
uniprot
proteins
pubmed
22632720
uniprot
proteins
pubmed
22832103
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
25915028
uniprot
proteins
pubmed
26797119
uniprot
proteins
pubmed
27052163
uniprot
proteins
pubmed
27172900
uniprot
proteins
pubmed
28007585
uniprot
proteins
pubmed
29056747
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26797119, ECO:0000269|PubMed:27172900}; Single-pass membrane protein {ECO:0000305|PubMed:26797119}. Presynaptic cell membrane {ECO:0000269|PubMed:27052163, ECO:0000269|PubMed:29056747}; Single-pass membrane protein {ECO:0000305|PubMed:26797119}. Synapse {ECO:0000269|PubMed:27052163, ECO:0000269|PubMed:29056747, ECO:0000305|PubMed:22632720}. Cell projection, axon {ECO:0000269|PubMed:29056747}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:D3ZFB6}. Postsynaptic density membrane {ECO:0000250|UniProtKB:D3ZFB6}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:D3ZFB6}.
uniprot
proteins
transmembrane_region
TRANSMEM 324..344; /note="Helical"; /evidence="ECO:0000255, ECO:0000305|PubMed:26797119
uniprot
proteins