LETMD1
entrez
25875
canonical
uniprot
Q6P1Q0
canonical
ensembl
ENSG00000050426
resolver
ensp
ENSP00000262055
resolver
ensp
ENSP00000389903
resolver
ensp
ENSP00000447419
resolver
ensp
ENSP00000450163
resolver
ensp
ENSP00000450333
resolver
ensp
ENSP00000553046
resolver
ensp
ENSP00000620057
resolver
ensp
ENSP00000620061
resolver
ensp
ENSP00000701229
resolver
ensp
ENSP00000701232
resolver
ensp
ENSP00000791795
resolver
enst
ENST00000547008
resolver
enst
ENST00000552739
resolver
genesymbol
LETMD1
resolver
hgnc
HGNC:24241
resolver
uniprot
A0A384P5D7
resolver
uniprot
A6NER7
resolver
uniprot
B3KXK7
resolver
uniprot
F8VP71
resolver
uniprot
F8W1Z2
resolver
uniprot
Q6X2E4
resolver
uniprot
Q6X2E5
resolver
uniprot
Q7L2G9
resolver
uniprot
Q7L690
resolver
uniprot
Q8WXW6
resolver
uniprot
Q96PK7
resolver
uniprot
Q9BY59
resolver
uniprot
Q9Y3X3
resolver
uniprot_entry
A0A384P5D7_HUMAN
resolver
uniprot_entry
F8VP71_HUMAN
resolver
uniprot_entry
F8W1Z2_HUMAN
resolver
uniprot_entry
LTMD1_HUMAN
resolver
uniprot_sec
A6NER7
resolver
uniprot_sec
B3KXK7
resolver
uniprot_sec
Q6X2E4
resolver
uniprot_sec
Q6X2E5
resolver
uniprot_sec
Q7L2G9
resolver
uniprot_sec
Q7L690
resolver
uniprot_sec
Q8WXW6
resolver
uniprot_sec
Q96PK7
resolver
uniprot_sec
Q9BY59
resolver
uniprot_sec
Q9Y3X3
resolver
amino_acid_sequence
MALSRVCWARSAVWGSAVTPGHFVTRRLQLGRSGLAWGAPRSSKLHLSPKADVKNLMSYVVTKTKAINGKYHRFLGRHFPRFYVLYTIFMKGLQMLWADAKKARRIKTNMWKHNIKFHQLPYREMEHLRQFRQDVTKCLFLGIISIPPFANYLVFLLMYLFPRQLLIRHFWTPKQQTDFLDIYHAFRKQSHPEIISYLEKVIPLISDAGLRWRLTDLCTKIQRGTHPAIHDILALRECFSNHPLGMNQLQALHVKALSRAMLLTSYLPPPLLRHRLKTHTTVIHQLDKALAKLGIGQLTAQEVKSACYLRGLNSTHIGEDRCRTWLGEWLQISCSLKEAELSLLLHNVVLLSTNYLGTRR
uniprot
proteins
function
FUNCTION: Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes. In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1 (By similarity). May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (PubMed:31980577). Involved in tumorigenesis and may function as a negative regulator of the p53/TP53 (PubMed:12879013). {ECO:0000250|UniProtKB:Q924L1}.
uniprot
proteins
mass_dalton
41790
uniprot
proteins
pubmed
12879013
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17943721
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18045496
uniprot
proteins
pubmed
31980577
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:17943721, ECO:0000269|PubMed:18045496}; Single-pass membrane protein {ECO:0000269|PubMed:18045496}. Nucleus {ECO:0000250|UniProtKB:Q924L1}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q924L1}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 138..158; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins