CEP68
entrez
23177
canonical
uniprot
Q76N32
canonical
ensembl
ENSG00000011523
resolver
ensp
ENSP00000260569
resolver
ensp
ENSP00000367229
resolver
ensp
ENSP00000515602
resolver
ensp
ENSP00000515890
resolver
ensp
ENSP00000557802
resolver
enst
ENST00000703985
resolver
enst
ENST00000704388
resolver
genesymbol
CEP68
resolver
genesymbol_syn
KIAA0582
resolver
hgnc
HGNC:29076
resolver
uniprot
A0A994J4E5
resolver
uniprot
B4DRQ1
resolver
uniprot
D6W5F1
resolver
uniprot
D6W5F2
resolver
uniprot
O60326
resolver
uniprot
Q9BQ18
resolver
uniprot
Q9UDM9
resolver
uniprot_entry
A0A994J4E5_HUMAN
resolver
uniprot_entry
CEP68_HUMAN
resolver
uniprot_sec
B4DRQ1
resolver
uniprot_sec
D6W5F1
resolver
uniprot_sec
D6W5F2
resolver
uniprot_sec
O60326
resolver
uniprot_sec
Q9BQ18
resolver
uniprot_sec
Q9UDM9
resolver
amino_acid_sequence
MALGEEKAEAEASEDTKAQSYGRGSCRERELDIPGPMSGEQPPRLEAEGGLISPVWGAEGIPAPTCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGESQVEKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQQPHSSGLSCLSQWKSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLAKVSSSLEPVVPQEPSSVVGLGPRPQWSPQPVFSGGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWNPNKEYEDLLDYTYPLRPGPQLPKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPAEATALPFSGPREPSLKQWPSRVPQKQGGMGLASWSQLASTPRAPGSRDARWERREPALRGAKDRLTIGKHLDMGSPQLRTRDRGWPSPRPEREKRTSQSARRPTCTESRWKSEEEVESDDEYLALPARLTQVSSLVSYLGSISTLVTLPTGDIKGQSPLEVSDSDGPASFPSSSSQSQLPPGAALQGSGDPEGQNPCFLRSFVRAHDSAGEGSLGSSQALGVSSGLLKTRPSLPARLDRWPFSDPDVEGQLPRKGGEQGKESLVQCVKTFCCQLEELICWLYNVADVTDHGTAARSNLTSLKSSLQLYRQFKKDIDEHQSLTESVLQKGEILLQCLLENTPVLEDVLGRIAKQSGELESHADRLYDSILASLDMLAGCTLIPDKKPMAAMEHPCEGV
uniprot
proteins
function
FUNCTION: Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}.
uniprot
proteins
mass_dalton
81102
uniprot
proteins
mutagenesis
MUTAGEN 331..337; /note="Missing: Prevents binding to BTRC and down-regulation of CEP68 during mitosis."; /evidence="ECO:0000269|PubMed:25503564"; MUTAGEN 332; /note="S->A: Prevents binding to BTRC and down-regulation of CEP68 during mitosis."; /evidence="ECO:0000269|PubMed:25503564"; MUTAGEN 337; /note="D->A: Reduces CEP68 binding to BTRC."; /evidence="ECO:0000269|PubMed:12168954
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PLK1 is required for binding to BTRC in prometaphase (PubMed:25503564). Phosphorylated directly or indirectly by NEK2 (PubMed:24554434). NEK2-mediated phosphorylation promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). {ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143}.; PTM: Ubiquitinated and targeted for proteasomal degradation in early mitosis by the SCF(BTRC) and/or SCF(FBXW11) E3 ubiquitin-protein ligase complexes (PubMed:25503564, PubMed:25704143). Degradation is complete by prometaphase and is required for removal of CDK5RAP2 from the peripheral pericentriolar material and subsequent centriole separation (PubMed:25503564). {ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143}.
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18042621
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24554434
uniprot
proteins
pubmed
25503564
uniprot
proteins
pubmed
25704143
uniprot
proteins
pubmed
30404835
uniprot
proteins
pubmed
31974111
uniprot
proteins
pubmed
9628581
uniprot
proteins
sequence_length
757
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:31974111}. Note=Localizes to thin fibers protruding away from the proximal ends of the two centrioles. Dissociates from interphase centrosomes at the onset of mitosis. {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143}.
uniprot
proteins