Kctd21
entrez
622320
canonical
uniprot
Q3URF8
canonical
ensembl
ENSMUSG00000044952
resolver
ensp
ENSMUSP00000051316
resolver
ensp
ENSMUSP00000207002
resolver
enst
ENSMUST00000054107
resolver
genesymbol
Kctd21
resolver
uniprot
B2RTJ2
resolver
uniprot
F6UH36
resolver
uniprot_entry
B2RTJ2_MOUSE
resolver
uniprot_entry
F6UH36_MOUSE
resolver
uniprot_entry
KCD21_MOUSE
resolver
amino_acid_sequence
MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPLIEALQEKEVELSKAEKNAMLNITLKQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTSCLFLKLLGSKLLYCSNGNLSSITSHLQDPNHLTLDWVANVEGLPEEEYTKQNLKRLWVVPANKQINSFQVFVEEVLKIALSDGFCIDSSHPHALDFMNNKIIRLIRYR
uniprot
proteins
function
FUNCTION: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). {ECO:0000250|UniProtKB:Q4G0X4}.
uniprot
proteins
mass_dalton
29623
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21472142
uniprot
proteins
sequence_length
260
uniprot
proteins