Snapin
entrez
20615
canonical
uniprot
Q9Z266
canonical
ensembl
ENSMUSG00000001018
resolver
ensp
ENSMUSP00000122090
resolver
genesymbol
Snapin
resolver
genesymbol_syn
Bloc1s7
resolver
genesymbol_syn
Snap25bp
resolver
genesymbol_syn
Snapap
resolver
uniprot
Q3U8V4
resolver
uniprot
Q922V7
resolver
uniprot_entry
SNAPN_MOUSE
resolver
uniprot_sec
Q3U8V4
resolver
uniprot_sec
Q922V7
resolver
amino_acid_sequence
MAAAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGVYPPGSPSK
uniprot
proteins
function
FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:16760431, PubMed:19546860, PubMed:21998198). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity). {ECO:0000250|UniProtKB:O95295, ECO:0000269|PubMed:16760431, ECO:0000269|PubMed:19546860, ECO:0000269|PubMed:21998198}.
uniprot
proteins
mass_dalton
14904
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="S->A: No effect."; /evidence="ECO:0000269|PubMed:11283605"; MUTAGEN 50; /note="S->A: Inhibition of phosphorylation."; /evidence="ECO:0000269|PubMed:11283605"; MUTAGEN 50; /note="S->D: 3.5-fold increase in SNAP25 binding."; /evidence="ECO:0000269|PubMed:11283605"; MUTAGEN 63; /note="T->A: No effect."; /evidence="ECO:0000269|PubMed:11283605
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKD, phosphorylation controls SNAPIN protein stability (By similarity). Phosphorylated by CSNK1D/CK1. {ECO:0000250, ECO:0000269|PubMed:11283605, ECO:0000269|PubMed:17101137}.
uniprot
proteins
protein_family
SNAPIN family
uniprot
proteins
pubmed
10195194
uniprot
proteins
pubmed
11283605
uniprot
proteins
pubmed
12877659
uniprot
proteins
pubmed
12887314
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16760431
uniprot
proteins
pubmed
17101137
uniprot
proteins
pubmed
19168546
uniprot
proteins
pubmed
19546860
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21998198
uniprot
proteins
sequence_length
136
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12877659}; Peripheral membrane protein {ECO:0000269|PubMed:12877659}; Cytoplasmic side {ECO:0000269|PubMed:12877659}. Cytoplasm, cytosol {ECO:0000269|PubMed:12877659}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12877659}. Golgi apparatus membrane {ECO:0000269|PubMed:17101137}. Lysosome membrane {ECO:0000250|UniProtKB:O95295}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:11283605}. Note=Colocalizes with NANOS1 and PUM2 in the perinuclear region of germ cells. {ECO:0000250|UniProtKB:O95295}.
uniprot
proteins