Serac1
entrez
321007
canonical
uniprot
Q3U213
canonical
ensembl
ENSMUSG00000015659
resolver
ensp
ENSMUSP00000024570
resolver
ensp
ENSMUSP00000095043
resolver
ensp
ENSMUSP00000286892
resolver
ensp
ENSMUSP00000286893
resolver
ensp
ENSMUSP00000286900
resolver
ensp
ENSMUSP00000286902
resolver
genesymbol
Serac1
resolver
genesymbol_syn
D17Ertd141e
resolver
uniprot
Q3TS62
resolver
uniprot
Q9D2G7
resolver
uniprot_entry
SRAC1_MOUSE
resolver
uniprot_sec
Q3TS62
resolver
uniprot_sec
Q9D2G7
resolver
amino_acid_sequence
MSLAAYCVICCRRIGSFAPRSKSRTPWRNIRNIIRFTGSLIVGGSLFITYEVLALKKSLMLDTQVVEREKMKSYIYVHKAPVDRLDNRGIVWQARKELHRAVRKLLAAAAKVLRSPFADSFSTVDIEDHDCAVWLLLRKSREDDLAARLQAVREMSEAHHWHDYQYRIIAQACDPRTLIGLARSKESDLRFFLPPPPLPSLKEDSSTEEELRHLLASLPQTELDECLQYFTSLALSESSQSLAAQKGGLWCFGGNGLPYAESFGKVPSATVEMFCLEAIVKHSEIPSHCDHIEAGGGLQLLQRLYQLHKDCPKVQRNVMRIIGNMALNEHLHPAIVHSGWVSLMAEALKSSHIMEASHAARTLANLDRETVGEKYQDGVYVLHPQCRTSQPIKADVLFIHGLMGAAFKTWRQHDSQRALTESAVVDEDRYTTCWPKTWLAKDCPSLRIISVEYDTSLSDWRARCPMERKSIAFRSNELLSKLRAAGVGDRPMIWISHSMGGLLVKKMLLEASKKPELNALINNTRGIIFYSVPHHGSRLAEYSVNIRYLLFPSLEVKELSKDSPALKTLQDDFLEFAKDKNFQVLNFVETQPTFIGSMIKLHVVPVESADLGIGDLIPVDVNHLNICKPKTKDAFLYQRTLQFICETLARDLEN
uniprot
proteins
function
FUNCTION: Facilitates the transport of serine from the cytosol to the mitochondria by interacting with and stabilizing Sideroflexin-1 (SFXN1), a mitochondrial serine transporter, playing a fundamental role in the one-carbon cycle responsible for the synthesis of nucleotides needed for mitochondrial DNA replication (PubMed:35235340). Plays an important role in the phosphatidylglycerol (PG) remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. Specifically involved in the exchange of the sn-1 acyl chain from PG 16:0/18:1(9Z) (also known as 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)) to PG 18:0/18:1(9Z) (also known as 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)), a step needed in the bis(monoacylglycerol)phosphate biosynthetic pathway. May have acyltransferase activity although the mechanism for PG remodeling has not been determined (By similarity). {ECO:0000250|UniProtKB:Q96JX3, ECO:0000269|PubMed:35235340}.
uniprot
proteins
mass_dalton
73987
uniprot
proteins
protein_family
SERAC1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15722415
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
35235340
uniprot
proteins
sequence_length
654
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:35235340}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000250}. Mitochondrion {ECO:0000269|PubMed:35235340}. Note=Localizes at the endoplasmic reticulum and at the endoplasmic reticulum-mitochondria interface. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..54; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins