Dnajc2
entrez
22791
canonical
uniprot
P54103
canonical
ensembl
ENSMUSG00000029014
resolver
ensp
ENSMUSP00000030771
resolver
ensp
ENSMUSP00000110849
resolver
enst
ENSMUST00000030771
resolver
enst
ENSMUST00000115195
resolver
genesymbol
Dnajc2
resolver
genesymbol_syn
Mida1
resolver
genesymbol_syn
Zrf1
resolver
uniprot
E9Q9H2
resolver
uniprot
Q61866
resolver
uniprot_entry
DNJC2_MOUSE
resolver
uniprot_entry
E9Q9H2_MOUSE
resolver
uniprot_sec
Q61866
resolver
amino_acid_sequence
MLLLPSAAEGQGTAITHALTSASSVCQVEPVGRWFEAFVKRRNRNASTSFQELEDKKELSEESEDEELQLEEFPMLKTLDPKDWKNQDHYAVLGLGHVRYTATQRQIKAAHKAMVLKHHPDKRKAAGEPIKEGDNDYFTCITKAYEMLSDPVKRRAFNSVDPTFDNSVPSKSEAKDNFFQVFSPVFERNSRWSNKKNVPKLGDMNSSFEDVDAFYSFWYNFDSWREFSYLDEEEKEKAECRDERKWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAKAEARRKEQEAKEKQRQAELEAVRLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSCKSWNHFSDNEADRVKMMEEVEKLCDRLELASLQGLNEILASSTREVGKAALEKQIEEVNEQMRREKEEADARMRQASKNAEKSTGGSGSGSKNWSEDDLQLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKRTAKDVISKAKSLQKLDPHQKDDINKKAFDKFKKEHGVASQADSAAPSERFEGPCIDSTPWTTEEQKLLEQALKTYPVNTPERWEKIAEAVPGRTKKDCMRRYKELVEMVKAKKAAQEQVLNASRARK
uniprot
proteins
function
FUNCTION: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. {ECO:0000250|UniProtKB:Q99543}.
uniprot
proteins
mass_dalton
71722
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in M (mitotic) phase. {ECO:0000250|UniProtKB:Q99543}.
uniprot
proteins
pubmed
10581180
uniprot
proteins
pubmed
10971652
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17622165
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7559602
uniprot
proteins
pubmed
8666407
uniprot
proteins
sequence_length
621
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:8666407}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q99543}.
uniprot
proteins