Q8K4K5
uniprot
Q8K4K5
canonical
amino_acid_sequence
MMKFRFRRQGADPQREKLKQELFTFHKTVEHGFPNQPSALAFDPELRIMAIGTRSGAVKIYGAPGVEFTGLHRDAATVTQMHFLPGQGRLLTLLDDSSLHLWEIIQRNGCAHLEEGLSFHPPSRPSFGNASFPAGLTRVTVVLLAAGDTVVLGTESGSIFFLDVATLALLEGQTLSPDEVLRSVPDDYRCGKALGPVESLQGHLQDPSKILIGYSRGLLVIWSQATQSVEHVFLGNQQLESLCWGRGGSNIISSHSDGSYAIWSTDTGSPPTLQPTVVTTPYGPFPCKAINKILWRSCESGDHFIIFSGGMPRASYGDRHCVSVLRAETLVTLDFTSRVIDFFTVHSTQPEDGFDNPQALAVLLEEELVVLDLQTPGWPAVPAPYLAPLHSSAITCSAHVANVPSKLWARIVSAGERQSPQPASSALSWPITGGRNLAQEPSQRGLLLTGHEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEHADSLAQAVEDDWPPFRKVGCFDPYSDDPRLGIQKVALCKYTAQMVVAGTAGQVLVLELSDVPGEHTVSVASVDLLQDREGFTWKGHERLSPHTGPLPWPAGFQPRVLIQCLPPAAVTAVALHAEWSLVAFGTSHGFGLFDYQRKSPVLARCTLHPNDSLAMEGPLSRVKSLKKSLRQSFRRIRKSRVSGKKRATTASSKLQEANAQLAEQTCPHDVEMTPVQRRIEPRSADDSLSGVVRCLYFADTFLRDATHHGPTMWAGTNSGSVFAYALEVPAATAGGEKRPEQAVEAVLGKEVQLMHRAPVVAIAVLDGRGRPLPEPYEASRDLAQAPDMQGGHAVLIASEEQFKVFTLPKVSAKTKFKLTAHEGCRVRKVALATFASVMSEDYAETCLACLTNLGDVHVFSVPGLRPQVHYSCIRKEDISGIASCVFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDISWPQNATQPRLQESPKLSQANGTRDIILAPESCEGSPSSAHSKRADTMEPPEAALSPVSIDSAASGDTMLDTTGDVTVEYVKDFLG
uniprot
proteins
function
FUNCTION: Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:21856246}.
uniprot
proteins
mass_dalton
112495
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKCI.
uniprot
proteins
protein_family
WD repeat L(2)GL family
uniprot
proteins
pubmed
12012002
uniprot
proteins
pubmed
21856246
uniprot
proteins
sequence_length
1036
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:21856246}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21856246}. Golgi apparatus membrane {ECO:0000269|PubMed:21856246}. Cell projection, axon {ECO:0000269|PubMed:21856246}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts (By similarity). Enriched in developing axons. {ECO:0000250}.
uniprot
proteins