Mepe
entrez
79110
canonical
uniprot
Q9ES02
canonical
genesymbol
Mepe
resolver
uniprot
A0A0G2K7K7
resolver
uniprot
D6C6P2
resolver
uniprot
Q8K3V0
resolver
uniprot_entry
MEPE_RAT
resolver
uniprot_sec
A0A0G2K7K7
resolver
uniprot_sec
D6C6P2
resolver
uniprot_sec
Q8K3V0
resolver
amino_acid_sequence
MQAVSVGLFLFSMTWAAPKLNEDGSSGGNQGNIHLASVKPEPMVGKGTEGGRDAPLHLLDQNRQGATLLRNITQPVKSLVTGTEVQSDRNKEKKPQSVLSVIPTDVHNTNDYSEDTENQQRDLLLQNSPGQSKHTPRARRSTHYLTHLPQIRKILSDFEDSASPDLLVRGDNDVPPFSGDGQHFMHTPDRGGAVGSDPESSAGHPVSGSSNVEIVDPHTNGLGSNEIPGREGHIGGAYATRGKTAQGAGSADVSLVEGSNEITGSTKFRELPGKEGNRVDASSQNAHQGKVEFHYPQAPSKEKVKGGSREHTGKAGYNEIPKSSKGGASKDAEESKGNQVTLTESQRFPGKGKGQSSHSLGNEVKSEEDSSNSLSREGIAIAHRRTSHPTRNRGMSQRRGSWASRRPHPHRRVSTRQRDSSESSSSGSSSESSGD
uniprot
proteins
function
FUNCTION: Regulates renal phosphate excretion (By similarity). Regulates bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (By similarity). Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Increases dental pulp stem cell proliferation. {ECO:0000250|UniProtKB:Q9NQ76}.
uniprot
proteins
mass_dalton
46516
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues in the ASARM motif; the phosphorylation is important for the inhibition of bone mineralization. {ECO:0000250|UniProtKB:Q9NQ76}.; PTM: Cleaved by CTSB/cathepsin B; the cleavage is blocked by metalloprotease PHEX. {ECO:0000250|UniProtKB:Q9NQ76}.
uniprot
proteins
protein_family
PF07175/osteoregulin family
uniprot
proteins
pubmed
10967096
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
19924383
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q8K4L6}. Secreted {ECO:0000250|UniProtKB:Q9NQ76}.
uniprot
proteins