KCNA3
entrez
3738
canonical
uniprot
P22001
canonical
ensembl
ENSG00000177272
resolver
ensp
ENSP00000358784
resolver
genesymbol
KCNA3
resolver
genesymbol_syn
HGK5
resolver
hgnc
HGNC:6221
resolver
uniprot
B2RA23
resolver
uniprot
Q5VWN2
resolver
uniprot
Q6P2D3
resolver
uniprot_entry
KCNA3_HUMAN
resolver
uniprot_sec
B2RA23
resolver
uniprot_sec
Q5VWN2
resolver
uniprot_sec
Q6P2D3
resolver
activity_regulation
ACTIVITY REGULATION: Activity is up-regulated by JAK2. {ECO:0000250|UniProtKB:P16390}.
uniprot
proteins
amino_acid_sequence
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
uniprot
proteins
function
FUNCTION: [Isoform 1]: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. {ECO:0000269|PubMed:36852591}.; FUNCTION: [Isoform 2]: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. {ECO:0000269|PubMed:1373731, ECO:0000269|PubMed:1547020, ECO:0000269|PubMed:1986382, ECO:0000269|PubMed:36852591}.; FUNCTION: [Isoform 3]: Lacks voltage-gated potassium channel activity. {ECO:0000269|PubMed:36852591}.
uniprot
proteins
mass_dalton
63842
uniprot
proteins
post_translational_modification
PTM: N-glycosylation promotes the cell surface expression. {ECO:0000250|UniProtKB:P15384}.; PTM: Phosphorylation on Tyr-499 inhibits its channel activity. {ECO:0000250|UniProtKB:P15384}.
uniprot
proteins
protein_family
A (Shaker) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv1.3/KCNA3 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
1373731
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1547020
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1986382
uniprot
proteins
pubmed
36852591
uniprot
proteins
pubmed
7829094
uniprot
proteins
sequence_length
575
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:36852591}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:36852591}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:36852591}.
uniprot
proteins
transmembrane_region
TRANSMEM 235..253; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 295..316; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 328..348; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 363..381; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 398..417; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 459..481; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins