Smyd2
entrez
226830
canonical
uniprot
Q8R5A0
canonical
ensembl
ENSMUSG00000026603
resolver
ensp
ENSMUSP00000027897
resolver
ensp
ENSMUSP00000284722
resolver
ensp
ENSMUSP00000284744
resolver
enst
ENSMUST00000027897
resolver
genesymbol
Smyd2
resolver
uniprot
Q3UBQ2
resolver
uniprot
Q9D177
resolver
uniprot_entry
Q9D177_MOUSE
resolver
uniprot_entry
SMYD2_MOUSE
resolver
uniprot_sec
Q3UBQ2
resolver
amino_acid_sequence
MRAEARGGLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLTVGERGHHCECCFARKEGLSKCGRCKQAFYCDVECQKEDWPLHKLECSSMVVLGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQFYSKYLEFPDHSSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGDEVFTSYIDLLYPTEDRNDRLRDSYFFTCECRECTTKDKDKAKVEVRKLSSPPQAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALKYGQKIIKPYSKHYPVYSLNVASMWLKLGRLYMGLENKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.354
uniprot
proteins
function
FUNCTION: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. {ECO:0000250|UniProtKB:Q9NRG4, ECO:0000269|PubMed:16805913}.
uniprot
proteins
mass_dalton
49567
uniprot
proteins
mutagenesis
MUTAGEN 240; /note="Y->F: Abolishes methyltransferase activity."; /evidence="ECO:0000269|PubMed:16805913
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16805913
uniprot
proteins
pubmed
18065756
uniprot
proteins
pubmed
20305823
uniprot
proteins
sequence_length
433
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus.
uniprot
proteins