Camkk1
entrez
60341
canonical
uniprot
P97756
canonical
ensembl
ENSRNOG00000018242
resolver
ensembl
ENSRNOG00055027466
resolver
ensembl
ENSRNOG00060018674
resolver
ensembl
ENSRNOG00065025095
resolver
ensp
ENSRNOP00000076910
resolver
ensp
ENSRNOP00000091768
resolver
ensp
ENSRNOP00055039163
resolver
ensp
ENSRNOP00060026187
resolver
ensp
ENSRNOP00065035370
resolver
enst
ENSRNOT00055047594
resolver
enst
ENSRNOT00060032174
resolver
enst
ENSRNOT00065043172
resolver
genesymbol
Camkk1
resolver
uniprot
Q64572
resolver
uniprot
Q794E3
resolver
uniprot_entry
KKCC1_RAT
resolver
uniprot_sec
Q64572
resolver
uniprot_sec
Q794E3
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Partially inhibited upon phosphorylation by PRCAKA/PKA. May be regulated through phosphorylation by CAMK1 and CAMK4. {ECO:0000269|PubMed:7642608}.
uniprot
proteins
amino_acid_sequence
MERSPAVCCQDPRAELVERVAAISVAHLEEAEEGPEPASNGVDPPPRARAASVIPGSASRPTPVRPSLSARKFSLQERPAGSCLEAQVGPYSTGPASHMSPRAWRRPTIESHHVAISDTEDCVQLNQYKLQSEIGKGAYGVVRLAYNEREDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAPQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDTGQSFSGKALDVWATGVTLYCFVYGKCPFIDEYILALHRKIKNEAVVFPEEPEVSEELKDLILKMLDKNPETRIGVSDIKLHPWVTKHGEEPLPSEEEHCSVVEVTEEEVKNSVKLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLLKEGCGEGGKSPELPGVQEDEAAS
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:7642608, ECO:0000269|PubMed:8631893, ECO:0000269|PubMed:9859994}.
uniprot
proteins
mass_dalton
55908
uniprot
proteins
mutagenesis
MUTAGEN 74; /note="S->A: Decrease in phosphorylation by PKA."; /evidence="ECO:0000269|PubMed:10187789"; MUTAGEN 108; /note="T->A: Decrease in phosphorylation and partial inhibition by PKA. Almost loss of inhibition by PKA; when associated with A-458."; /evidence="ECO:0000269|PubMed:10187789, ECO:0000269|PubMed:9195898"; MUTAGEN 172; /note="R->E: Loss of substrate recognition and interaction with CAMK4."; /evidence="ECO:0000269|PubMed:10336483"; MUTAGEN 177; /note="R->E: Loss of substrate recognition and interaction with CAMK4."; /evidence="ECO:0000269|PubMed:10336483"; MUTAGEN 458; /note="S->A: Decrease in phosphorylation and partial inhibition by PKA. Almost loss of inhibition by PKA; when associated with A-108."; /evidence="ECO:0000269|PubMed:9195898"; MUTAGEN 459; /note="F->D: Loss of binding to Ca(2+)/calmodulin."; /evidence="ECO:0000269|PubMed:10467092"; MUTAGEN 463; /note="F->D: Loss of binding to Ca(2+)/calmodulin."; /evidence="ECO:0000269|PubMed:10467092
uniprot
proteins
post_translational_modification
PTM: Appears to be autophosphorylated. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. May be phosphorylated by CAMK1 and CAMK4. {ECO:0000269|PubMed:10187789, ECO:0000269|PubMed:9195898}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
10187789
uniprot
proteins
pubmed
10336483
uniprot
proteins
pubmed
10467092
uniprot
proteins
pubmed
10651863
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7642608
uniprot
proteins
pubmed
8631893
uniprot
proteins
pubmed
8827455
uniprot
proteins
pubmed
8929978
uniprot
proteins
pubmed
9195898
uniprot
proteins
pubmed
9335539
uniprot
proteins
pubmed
9859994
uniprot
proteins
sequence_length
505
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
uniprot
proteins