Lamp3
entrez
239739
canonical
uniprot
Q7TST5
canonical
ensembl
ENSMUSG00000041247
resolver
ensp
ENSMUSP00000080556
resolver
enst
ENSMUST00000081880
resolver
genesymbol
Lamp3
resolver
uniprot
Q8BZW9
resolver
uniprot
Q8C1F6
resolver
uniprot_entry
LAMP3_MOUSE
resolver
uniprot_entry
Q8BZW9_MOUSE
resolver
uniprot_sec
Q8C1F6
resolver
amino_acid_sequence
MPGQISAVAVLFLSLTVILHGYQIREKEFPKARGYLQYTATSAEQITTKPLLQLINQRSHITLASRFKDDYIQMAAETSAIENTAHITMKTVTPVTTKSLPPISSASYTFVRSNNAHMTASSTDDTIGSGSIAHLPVPTTRASLAIVNYITGRATQLGGQTTLPKTFFTASHKSTTNQRPTLSTNVLGTSTPTHKDRSTTSPVPLVPRPTLVTWSSPAKIGTYEVLNGSRLCIKAEMGLALIVQEKDLDSATQRYFNIDPSLTHASGKCDSQKSNLFLNFQGGSVNITFTKEENLYYISEVGAYLTISNTEKTYQGKKNTLMMFETVVGHSFKCVSEQSIQLSAQLQMKTMNIHLQAFDFEGDSFGNVNECLSDYTVVLPMVAIIVVVICVVGLSVYKIRQRHQSSAYQRI
uniprot
proteins
function
FUNCTION: Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity. {ECO:0000250|UniProtKB:Q9UQV4}.
uniprot
proteins
mass_dalton
45129
uniprot
proteins
protein_family
LAMP family
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell surface {ECO:0000250|UniProtKB:Q9UQV4}. Lysosome membrane {ECO:0000250|UniProtKB:Q9UQV4}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9UQV4}; Single-pass type I membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q9UQV4}; Single-pass type I membrane protein {ECO:0000255}. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells. {ECO:0000250|UniProtKB:Q9UQV4}.
uniprot
proteins
transmembrane_region
TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00740
uniprot
proteins