Eya4
entrez
14051
canonical
uniprot
Q9Z191
canonical
ensembl
ENSMUSG00000010461
resolver
ensp
ENSMUSP00000090335
resolver
ensp
ENSMUSP00000151287
resolver
ensp
ENSMUSP00000151483
resolver
ensp
ENSMUSP00000201866
resolver
ensp
ENSMUSP00000201867
resolver
ensp
ENSMUSP00000201869
resolver
ensp
ENSMUSP00000201870
resolver
ensp
ENSMUSP00000201871
resolver
ensp
ENSMUSP00000201872
resolver
enst
ENSMUST00000092665
resolver
enst
ENSMUST00000219315
resolver
enst
ENSMUST00000220299
resolver
genesymbol
Eya4
resolver
uniprot
A0A1W2P721
resolver
uniprot
F7BVV9
resolver
uniprot
Q0VAV8
resolver
uniprot
Q8BY78
resolver
uniprot_entry
A0A1W2P721_MOUSE
resolver
uniprot_entry
EYA4_MOUSE
resolver
uniprot_entry
F7BVV9_MOUSE
resolver
uniprot_entry
Q8BY78_MOUSE
resolver
uniprot_sec
Q0VAV8
resolver
amino_acid_sequence
MEDTQDLNEQSVKKTCPEADVSEPQNSRSMEMQDLASPHALVGGSDTPGSSKLDKSGLSSTSVTTNGTGVSLLAVKTEPLHSSESTTTTGDGALDTFTGSVITSSGYSPRSAQQYSPQLYPSKPYPHILSTPAAQTMSAYAGQTQYSGMQQPAVYTAYSQTGQPYSLPAYDLGVMLPAIKTESGLSQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQMPGSSFAPSSTIYANNSVSNSTNFSSSQQDYPSYTAFGQNQYAQYYSASTYGAYMTSNNTADGTSSSTSTYQLQESLQGLTSQPGEFDTVQSPSTPIKDLDDRTCRSSGSKSRGRGRKNNPSPPPDSDLERVFVWDLDETIIVFHSLLTGSYAQKYGKDPPMAVTLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHAAASSANLCLPTGVRGGVDWMRKLAFRYRRVKELYNTYKNNVGGLLGPAKRDAWLQLRAEIEGLTDSWLTNALKSLSIISTRSNCVNVLVTTTQLIPALAKVLLYSLGGAFPIENIYSATKIGKESCFERIVSRFGTNITYVVIGDGRDEEHAANQHNMPFWRISSHSDLLALHQALELEYL
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity). {ECO:0000250|UniProtKB:Q99502}.
uniprot
proteins
mass_dalton
66875
uniprot
proteins
protein_family
EYA family
uniprot
proteins
protein_family
HAD-like hydrolase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9887327
uniprot
proteins
sequence_length
616
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99502}. Nucleus {ECO:0000250|UniProtKB:Q99502}.
uniprot
proteins