Saraf
entrez
67887
canonical
uniprot
Q8R3Q0
canonical
ensembl
ENSMUSG00000031532
resolver
ensp
ENSMUSP00000033933
resolver
ensp
ENSMUSP00000159294
resolver
enst
ENSMUST00000033933
resolver
enst
ENSMUST00000239436
resolver
genesymbol
Saraf
resolver
genesymbol_syn
Tmem66
resolver
uniprot
A0A0R4J0D1
resolver
uniprot
Q8C2F1
resolver
uniprot
Q8C6G7
resolver
uniprot
Q8N9S4
resolver
uniprot
Q8R233
resolver
uniprot
Q9D8R1
resolver
uniprot_entry
A0A0R4J0D1_MOUSE
resolver
uniprot_entry
SARAF_MOUSE
resolver
uniprot_sec
Q8C2F1
resolver
uniprot_sec
Q8C6G7
resolver
uniprot_sec
Q8N9S4
resolver
uniprot_sec
Q8R233
resolver
uniprot_sec
Q9D8R1
resolver
amino_acid_sequence
MAVAAVGRPRALRCPLLLLLSLLLVAGPALGWNDPDRILLRDVKALTLYSDRYTTSRRLDPIPQLKCVGGTAGCEAYTPRVIQCQNKGWDGYDVQWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLKKLKESGKHQGFSDYYHKLYSSDSCGFITIAVLFVLAFAVYKLFLSDGQGSPPPYSEHPPYSEHSQRFASAAGAPPPGFKSEFTGPQNTGYGASSGFGSAFGGQGYGSSGPGFWSGLGAGGLLGYLFGSNRAATPFSDSWYHPAYPPSHSGAWNSRAYSPLGGGAGSYCASSNADSRTRTASGYGGTRRR
uniprot
proteins
function
FUNCTION: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
35856
uniprot
proteins
protein_family
SARAF family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1-dependent manner following cytosolic Ca(2+) elevation. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins