B4galt5
entrez
56336
canonical
uniprot
Q9JMK0
canonical
ensembl
ENSMUSG00000017929
resolver
ensp
ENSMUSP00000104844
resolver
enst
ENSMUST00000109221
resolver
genesymbol
B4galt5
resolver
genesymbol_syn
Bgt-5
resolver
uniprot
A2A5T7
resolver
uniprot
Q3U7I0
resolver
uniprot_entry
B4GT5_MOUSE
resolver
uniprot_entry
Q3U7I0_MOUSE
resolver
uniprot_sec
A2A5T7
resolver
amino_acid_sequence
MRARRGLLRLPRRSLLAALFFFSLSSSLLYFVYVAPGIVNTYLFMVQAQGILLRDNVRTIGAQVYEQVVRSAYAKRNSSLNDSDYPLDLNHSEAFPPTTTFLPEDFTYFANHPCPERLPSMKGPIDINMSEIAMDDIHELFSRDPAIKLGGHWKPADCVPRWKVAILIPFRNRHEHLPVLLRHLLPMLQRQRLQFAFYVIEQVGTQPFNRAMLFNVGFQEAMKDLDWDCLIFHDVDHIPESDRNYYGCGQMPRHFATKLDKYMYLLPYTEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVQNAGYSVSRPEGDTGKYKSIPHHHRGEVQFLGRYALLRKSKERQGLDGLNNLNYSANVTYDALYKNITVNLTPELAQVTEY
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.1.274
uniprot
proteins
function
FUNCTION: Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:21057870, PubMed:23882130, PubMed:30114188). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (PubMed:30114188). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (PubMed:29415997). Essential for extraembryonic development during early embryogenesis (PubMed:20574042, PubMed:21057870). {ECO:0000269|PubMed:20574042, ECO:0000269|PubMed:21057870, ECO:0000269|PubMed:23882130, ECO:0000269|PubMed:29415997, ECO:0000269|PubMed:30114188}.
uniprot
proteins
mass_dalton
44814
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation.; PATHWAY: Sphingolipid metabolism.
uniprot
proteins
protein_family
Glycosyltransferase 7 family
uniprot
proteins
pubmed
11145975
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20574042
uniprot
proteins
pubmed
21057870
uniprot
proteins
pubmed
23882130
uniprot
proteins
pubmed
29415997
uniprot
proteins
pubmed
30114188
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P15291}; Single-pass type II membrane protein. Golgi apparatus {ECO:0000250|UniProtKB:A0A1S6M251}. Note=Trans cisternae of Golgi stack. {ECO:0000250|UniProtKB:P15291}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..35; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins