Stat4
entrez
20849
canonical
uniprot
P42228
canonical
ensembl
ENSMUSG00000062939
resolver
ensp
ENSMUSP00000027277
resolver
ensp
ENSMUSP00000130713
resolver
enst
ENSMUST00000027277
resolver
enst
ENSMUST00000168302
resolver
genesymbol
Stat4
resolver
uniprot
F6V373
resolver
uniprot
Q3V157
resolver
uniprot_entry
F6V373_MOUSE
resolver
uniprot_entry
Q3V157_MOUSE
resolver
uniprot_entry
STAT4_MOUSE
resolver
amino_acid_sequence
MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIETQDWEVASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAANMPIQGPLEKSLQSSSVSERQRNVEHKVSAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTMDQGDKNSILVNQEVLTLLQEMLNSLDFKRKEALSKMTQIVNETDLLMNSMLLEELQDWKKRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRQQLEKLQEQSTKMTYEGDPIPAQRAHLLERATFLIYNLFKNSFVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTHVKAMSSEESSNGSLSVEFRHLQPKEMKCSTGSKGNEGCHMVTEELHSITFETQICLYGLTINLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSVTLGQLLEVMSWQFSSYVGRGLNSEQLNMLAEKLTVQSNYNDGHLTWAKFCKEHLPGKTFTFWTWLEAILDLIKKHILPLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDQSENGEVRFHSVEPYNKGRLSALAFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTERGDKGYVPSVFIPISTIRSDSTEPQSPSDLLPMSPSAYAVLRENLSPTTIETAMNSPYSAE
uniprot
proteins
function
FUNCTION: Transcriptional regulator mainly expressed in hematopoietic cells that plays a critical role in cellular growth, differentiation and immune response. Plays a key role in the differentiation of T-helper 1 cells and the production of interferon-gamma (PubMed:8700209). Also participates in multiple neutrophil functions including chemotaxis and production of the neutrophil extracellular traps (PubMed:34138758). After IL12 binding to its receptor IL12RB2, STAT4 interacts with the intracellular domain of IL12RB2 and becomes tyrosine phosphorylated. Phosphorylated STAT4 then homodimerizes and migrates to the nucleus where it can recognize STAT target sequences present in IL12 responsive genes. Although IL12 appears to be the predominant activating signal, STAT4 can also be phosphorylated and activated in response to IFN-gamma stimulation via JAK1 and TYK2 and in response to different interleukins including IL23, IL2 and IL35 (By similarity). Transcription activation of IFN-gamma gene is mediated by interaction with JUN that forms a complex that efficiently interacts with the AP-1-related sequence of the IFN-gamma promoter (PubMed:14734615). In response to IFN-alpha/beta signaling, acts as a transcriptional repressor and suppresses IL5 and IL13 mRNA expression during response to T-cell receptor (TCR) activation (By similarity). {ECO:0000250|UniProtKB:Q14765, ECO:0000269|PubMed:14734615, ECO:0000269|PubMed:34138758, ECO:0000269|PubMed:8700209}.
uniprot
proteins
mass_dalton
85941
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-668 is required for JAK2-mediated phosphorylation and activation of STAT4. {ECO:0000250|UniProtKB:Q14765}.; PTM: Tyrosine phosphorylated upon IL12 and IFN-alpha activation, but not by IFN-gamma in T-lymphocytes and NK cells. Serine phosphorylation is required for maximal transcriptional activity but not for DNA binding. Phosphorylation by MAP2K6 at Ser-722 is required for full transcriptional activity induced by IL12. However this serine phosphorylation is not required for cell proliferation although critical for IFN-gamma production. {ECO:0000250|UniProtKB:Q14765}.
uniprot
proteins
protein_family
Transcription factor STAT family
uniprot
proteins
pubmed
14734615
uniprot
proteins
pubmed
18234692
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34138758
uniprot
proteins
pubmed
7545930
uniprot
proteins
pubmed
8007943
uniprot
proteins
pubmed
8700209
uniprot
proteins
pubmed
9461439
uniprot
proteins
sequence_length
749
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250|UniProtKB:Q14765}. Note=Translocated into the nucleus in response to phosphorylation. {ECO:0000250|UniProtKB:Q14765}.
uniprot
proteins