Tp73
entrez
22062
canonical
uniprot
Q9JJP2
canonical
ensembl
ENSMUSG00000029026
resolver
ensp
ENSMUSP00000095368
resolver
ensp
ENSMUSP00000101269
resolver
ensp
ENSMUSP00000114418
resolver
ensp
ENSMUSP00000159346
resolver
enst
ENSMUST00000105644
resolver
enst
ENSMUST00000239448
resolver
genesymbol
Tp73
resolver
genesymbol
Trp73
resolver
genesymbol_syn
P73
resolver
genesymbol_syn
Trp73
resolver
uniprot
B1AX89
resolver
uniprot
B1AX90
resolver
uniprot
Q3UT91
resolver
uniprot
Q9CU77
resolver
uniprot
Q9D6A3
resolver
uniprot
Q9JJP1
resolver
uniprot
Q9WUJ0
resolver
uniprot
Z4YK94
resolver
uniprot_entry
P73_MOUSE
resolver
uniprot_entry
Q9D6A3_MOUSE
resolver
uniprot_entry
Z4YK94_MOUSE
resolver
uniprot_sec
B1AX89
resolver
uniprot_sec
B1AX90
resolver
uniprot_sec
Q3UT91
resolver
uniprot_sec
Q9CU77
resolver
uniprot_sec
Q9JJP1
resolver
uniprot_sec
Q9WUJ0
resolver
amino_acid_sequence
MAQTSSSSSSTFEHLWSSLEPDSTYFDLPQPSQGTSEASGSEESNMDVFHLQGMAQFNLLSSAMDQMGSRAAPASPYTPEHAASAPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDIVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLAQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILVIITLETRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESTTKNGAASKRAFKQSPPAIPALGTNVKKRRHGDEDMFYMHVRGRENFEILMKVKESLELMELVPQPLVDSYRQQQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGVNKLPSVNQLVGQPPPHSSAAGPNLGPMGSGMLNSHGHSMPANGEMNGGHSSQTMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIECFTSQGLQSIYHLQNLTIEDLGALKVPDQYRMTIWRGLQDLKQSHDCGQQLLRSSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGAGAVTGPDEWADFGFDLPDCKSRKQPIKEEFTETESH
uniprot
proteins
function
FUNCTION: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression, essential for the positive regulation of lung ciliated cell differentiation (PubMed:26947080). {ECO:0000250|UniProtKB:O15350, ECO:0000269|PubMed:10232589, ECO:0000269|PubMed:11932750, ECO:0000269|PubMed:26947080}.
uniprot
proteins
mass_dalton
69096
uniprot
proteins
post_translational_modification
PTM: Sumoylated on Lys-622, which potentiates proteasomal degradation but does not affect transcriptional activity. {ECO:0000250}.; PTM: Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function (By similarity). Higher levels of phosphorylation seen in striatal neurons of. mutant huntingtin (htt) transgenic mice. {ECO:0000250, ECO:0000269|PubMed:16461361}.; PTM: Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
P53 family
uniprot
proteins
pubmed
10232589
uniprot
proteins
pubmed
10716451
uniprot
proteins
pubmed
11932750
uniprot
proteins
pubmed
15113856
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16461361
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26947080
uniprot
proteins
sequence_length
631
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15113856}. Cytoplasm {ECO:0000250}. Note=Accumulates in the nucleus in response to DNA damage. {ECO:0000269|PubMed:15113856}.
uniprot
proteins