Pth
entrez
19226
canonical
uniprot
Q9Z0L6
canonical
ensembl
ENSMUSG00000059077
resolver
ensp
ENSMUSP00000078723
resolver
enst
ENSMUST00000079793
resolver
genesymbol
Pth
resolver
uniprot_entry
PTHY_MOUSE
resolver
amino_acid_sequence
MMSANTVAKVMIIMLAVCLLTQTDGKPVRKRAVSEIQLMHNLGKHLASMERMQWLRRKLQDMHNFVSLGVQMAARDGSHQKPTKKEENVLVDGNPKSLGEGDKADVDVLVKSKSQ
uniprot
proteins
function
FUNCTION: Peptide hormone secreted by parathyroid chief cells that acts as a primary endocrine regulator of extracellular calcium and phosphate homeostasis, acting primarily on bone and kidney to maintain serum calcium levels within a narrow range (PubMed:11606467, PubMed:19968565). Acts by binding and activating the G protein-coupled receptor PTH1R, engaging the receptor to activate G(s)-mediated cAMP/PKA signaling (By similarity). In bone, acts indirectly on osteoclasts by binding PTH1R on cells of the osteoblast/osteocyte lineage, where it increases expression of TNFSF11/RANKL and decreases expression of TNFRSF11B/OPG, thereby raising the RANKL/OPG ratio and stimulating osteoclast differentiation and bone resorption (By similarity). Stimulates also [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). In distal renal tubule cells, stimulates active Ca(2+) reabsorption via the adenylyl cyclase-cAMP-protein kinase A (PKA) pathway leading to the phosphorylation and activation of the calcium selective cation channel TRPV5 (By similarity). Acting on PTH1R in proximal renal tubule cells, decreases reabsorption of filtered phosphate by reducing apical abundance of SLC34A1, through a mechanism involving PTH1R-activated PKC-mediated phosphorylation of the scaffold NHERF1, causing dissociation of the NHERF1-SLC34A1 complex and subsequent clathrin-mediated endocytosis and lysosomal degradation of the cotransporter (PubMed:17975671). Activates also transcription of CYP27B1 (25-hydroxyvitamin D3 1-alpha-hydroxylase) through a cAMP/PKA/SIK2-SIK3/CRTC2 axis, thereby increasing renal synthesis of the active vitamin D metabolite 1,25-dihydroxyvitamin D(3) (PubMed:36862513). {ECO:0000250|UniProtKB:P01270, ECO:0000269|PubMed:11606467, ECO:0000269|PubMed:17975671, ECO:0000269|PubMed:19968565, ECO:0000269|PubMed:36862513}.
uniprot
proteins
mass_dalton
12825
uniprot
proteins
protein_family
Parathyroid hormone family
uniprot
proteins
pubmed
11606467
uniprot
proteins
pubmed
11994406
uniprot
proteins
pubmed
12370121
uniprot
proteins
pubmed
12671051
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17975671
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19968565
uniprot
proteins
pubmed
36862513
uniprot
proteins
sequence_length
115
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11606467}.
uniprot
proteins