IL10
entrez
3586
canonical
uniprot
P22301
canonical
ensembl
ENSG00000136634
resolver
ensp
ENSP00000412237
resolver
ensp
ENSP00000493073
resolver
enst
ENST00000423557
resolver
enst
ENST00000471071
resolver
genesymbol
IL10
resolver
hgnc
HGNC:5962
resolver
uniprot
A0A286YEX3
resolver
uniprot
Q6FGW4
resolver
uniprot_entry
A0A286YEX3_HUMAN
resolver
uniprot_entry
IL10_HUMAN
resolver
uniprot_entry
Q6FGW4_HUMAN
resolver
amino_acid_sequence
MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN
uniprot
proteins
function
FUNCTION: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF (PubMed:11564774, PubMed:1940799, PubMed:7512027). Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed:8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity). {ECO:0000250|UniProtKB:P18893, ECO:0000269|PubMed:11564774, ECO:0000269|PubMed:16982608, ECO:0000269|PubMed:18025162, ECO:0000269|PubMed:1940799, ECO:0000269|PubMed:7512027, ECO:0000269|PubMed:8144879}.
uniprot
proteins
mass_dalton
20517
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="R->A: About 80% loss of IL10RA binding."; /evidence="ECO:0000269|PubMed:16982608
uniprot
proteins
protein_family
IL-10 family
uniprot
proteins
pubmed
11485736
uniprot
proteins
pubmed
11564774
uniprot
proteins
pubmed
12121653
uniprot
proteins
pubmed
12825869
uniprot
proteins
pubmed
14657427
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15837194
uniprot
proteins
pubmed
16982608
uniprot
proteins
pubmed
18025162
uniprot
proteins
pubmed
1847510
uniprot
proteins
pubmed
1940799
uniprot
proteins
pubmed
7512027
uniprot
proteins
pubmed
7547951
uniprot
proteins
pubmed
8144879
uniprot
proteins
pubmed
8364028
uniprot
proteins
pubmed
8590020
uniprot
proteins
pubmed
8897595
uniprot
proteins
pubmed
9405662
uniprot
proteins
sequence_length
178
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins