STAM
entrez
8027
canonical
uniprot
Q92783
canonical
ensembl
ENSG00000136738
resolver
ensp
ENSP00000366746
resolver
ensp
ENSP00000562788
resolver
ensp
ENSP00000791087
resolver
genesymbol
STAM
resolver
genesymbol_syn
STAM1
resolver
hgnc
HGNC:11357
resolver
uniprot
B0YJ99
resolver
uniprot
B4DZT2
resolver
uniprot
D3DRU5
resolver
uniprot
Q8N6D9
resolver
uniprot_entry
B4DZT2_HUMAN
resolver
uniprot_entry
STAM1_HUMAN
resolver
uniprot_sec
B0YJ99
resolver
uniprot_sec
D3DRU5
resolver
uniprot_sec
Q8N6D9
resolver
amino_acid_sequence
MPLFATNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVANKKEEEDLAKAIELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFVTADLTAEPEMIKTEKKTVQFSDDVQVETIEPEPEPAFIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQNQPYYMQSSGVSGSQVYAGPPPSGAYLVAGNAQMSHLQSYSLPPEQLSSLSQAVVPPSANPALPSQQTQAAYPNTMVSSVQGNTYPSQAPVYSPPPAATAAAATADVTLYQNAGPNMPQVPNYNLTSSTLPQPGGSQQPPQPQQPYSQKALL
uniprot
proteins
function
FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.; FUNCTION: (Microbial infection) Plays an important role in Dengue virus entry. {ECO:0000269|PubMed:29742433}.
uniprot
proteins
mass_dalton
59180
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB. {ECO:0000269|PubMed:11687594, ECO:0000269|PubMed:20494825}.; PTM: Ubiquitinated by ITCH. {ECO:0000269|PubMed:24790097}.
uniprot
proteins
protein_family
STAM family
uniprot
proteins
pubmed
10383417
uniprot
proteins
pubmed
11687594
uniprot
proteins
pubmed
12551915
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
19278655
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20150893
uniprot
proteins
pubmed
20494825
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23166352
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24790097
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29742433
uniprot
proteins
pubmed
8780729
uniprot
proteins
pubmed
9407053
uniprot
proteins
sequence_length
540
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:23166352, ECO:0000269|PubMed:24790097}; Peripheral membrane protein {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}; Cytoplasmic side {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}.
uniprot
proteins