FCRL4
entrez
83417
canonical
uniprot
Q96PJ5
canonical
ensembl
ENSG00000163518
resolver
ensp
ENSP00000271532
resolver
genesymbol
FCRL4
resolver
genesymbol_syn
FCRH4
resolver
genesymbol_syn
IFGP2
resolver
genesymbol_syn
IRTA1
resolver
hgnc
HGNC:18507
resolver
uniprot
Q96PJ3
resolver
uniprot
Q96RE0
resolver
uniprot_entry
FCRL4_HUMAN
resolver
uniprot_sec
Q96PJ3
resolver
uniprot_sec
Q96RE0
resolver
amino_acid_sequence
MLLWASLLAFAPVCGQSAAAHKPVISVHPPWTTFFKGERVTLTCNGFQFYATEKTTWYHRHYWGEKLTLTPGNTLEVRESGLYRCQARGSPRSNPVRLLFSSDSLILQAPYSVFEGDTLVLRCHRRRKEKLTAVKYTWNGNILSISNKSWDLLIPQASSNNNGNYRCIGYGDENDVFRSNFKIIKIQELFPHPELKATDSQPTEGNSVNLSCETQLPPERSDTPLHFNFFRDGEVILSDWSTYPELQLPTVWRENSGSYWCGAETVRGNIHKHSPSLQIHVQRIPVSGVLLETQPSGGQAVEGEMLVLVCSVAEGTGDTTFSWHREDMQESLGRKTQRSLRAELELPAIRQSHAGGYYCTADNSYGPVQSMVLNVTVRETPGNRDGLVAAGATGGLLSALLLAVALLFHCWRRRKSGVGFLGDETRLPPAPGPGESSHSICPAQVELQSLYVDVHPKKGDLVYSEIQTTQLGEEEEANTSRTLLEDKDVSVVYSEVKTQHPDNSAGKISSKDEES
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2). {ECO:0000269|PubMed:12619161}.; DISEASE: Note=A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. {ECO:0000269|PubMed:11290337}.
uniprot
proteins
function
FUNCTION: May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response. {ECO:0000269|PubMed:14597715}.
uniprot
proteins
mass_dalton
57224
uniprot
proteins
mutagenesis
MUTAGEN 451; /note="Y->F: No effect on function, phosphorylation and interaction with PTPN6 and PTPN11."; /evidence="ECO:0000269|PubMed:14597715"; MUTAGEN 463; /note="Y->F: Loss of function, phosphorylation and interaction with PTPN6 and PTPN11."; /evidence="ECO:0000269|PubMed:14597715"; MUTAGEN 493; /note="Y->F: Loss of interaction with PTPN6 and PTPN11 and partial loss of function and phosphorylation."; /evidence="ECO:0000269|PubMed:14597715
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on cytoplasmic tyrosines upon activation. {ECO:0000269|PubMed:14597715}.
uniprot
proteins
pubmed
11290337
uniprot
proteins
pubmed
11493702
uniprot
proteins
pubmed
11929751
uniprot
proteins
pubmed
12037601
uniprot
proteins
pubmed
12619161
uniprot
proteins
pubmed
12881317
uniprot
proteins
pubmed
14597715
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16079106
uniprot
proteins
pubmed
16157685
uniprot
proteins
pubmed
16849395
uniprot
proteins
sequence_length
515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16157685, ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:16157685, ECO:0000269|PubMed:16849395}.
uniprot
proteins
transmembrane_region
TRANSMEM 388..408; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins