GC
entrez
2638
canonical
uniprot
P02774
canonical
ensembl
ENSG00000145321
resolver
ensp
ENSP00000273951
resolver
ensp
ENSP00000421725
resolver
ensp
ENSP00000422664
resolver
ensp
ENSP00000552480
resolver
genesymbol
GC
resolver
hgnc
HGNC:4187
resolver
uniprot
B4DPP2
resolver
uniprot
D6RAK8
resolver
uniprot
Q16309
resolver
uniprot
Q16310
resolver
uniprot
Q53F31
resolver
uniprot
Q6GTG1
resolver
uniprot_entry
VTDB_HUMAN
resolver
uniprot_sec
B4DPP2
resolver
uniprot_sec
D6RAK8
resolver
uniprot_sec
Q16309
resolver
uniprot_sec
Q16310
resolver
uniprot_sec
Q53F31
resolver
uniprot_sec
Q6GTG1
resolver
amino_acid_sequence
MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAKLPDATPTELAKLVNKHSDFASNCCSINSPPLYCDSEIDAELKNIL
uniprot
proteins
function
FUNCTION: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. {ECO:0000305|PubMed:16302727}.
uniprot
proteins
mass_dalton
52918
uniprot
proteins
post_translational_modification
PTM: Allele GC*1S is O-glycosylated at Thr-436 (PubMed:20079467). The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated (PubMed:17360250). The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated. {ECO:0000269|PubMed:17360250, ECO:0000269|PubMed:20079467, ECO:0000305|PubMed:16302727}.
uniprot
proteins
protein_family
ALB/AFP/VDB family
uniprot
proteins
pubmed
11799400
uniprot
proteins
pubmed
1352271
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16302727
uniprot
proteins
pubmed
17360250
uniprot
proteins
pubmed
20079467
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
218624
uniprot
proteins
pubmed
2415977
uniprot
proteins
pubmed
2416779
uniprot
proteins
pubmed
2423133
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2958390
uniprot
proteins
pubmed
7505619
uniprot
proteins
pubmed
7725672
uniprot
proteins
pubmed
8325650
uniprot
proteins
sequence_length
474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2423133}.
uniprot
proteins