Parva
entrez
57341
canonical
uniprot
Q9HB97
canonical
ensembl
ENSRNOG00000015713
resolver
ensp
ENSRNOP00000088590
resolver
ensp
ENSRNOP00000090231
resolver
enst
ENSRNOT00000099634
resolver
genesymbol
Parva
resolver
genesymbol_syn
Actp
resolver
uniprot
A0A8I6AA82
resolver
uniprot_entry
A0A8I6AA82_RAT
resolver
uniprot_entry
PARVA_RAT
resolver
amino_acid_sequence
MATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSEFQEEGMNAINLPLSPISFELDPEDTMLEENEVRTMVDPNSRNDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINEALKLPPRSIKWNVDSVHAKNLVAILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELMQDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVE
uniprot
proteins
function
FUNCTION: Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (By similarity). {ECO:0000250|UniProtKB:Q9NVD7, ECO:0000269|PubMed:11134073}.
uniprot
proteins
mass_dalton
42292
uniprot
proteins
protein_family
Parvin family
uniprot
proteins
pubmed
11134073
uniprot
proteins
pubmed
15817463
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:11134073}. Cell membrane {ECO:0000269|PubMed:11134073}; Peripheral membrane protein {ECO:0000269|PubMed:11134073}; Cytoplasmic side {ECO:0000269|PubMed:11134073}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11134073}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}.
uniprot
proteins