Brap
entrez
72399
canonical
uniprot
Q99MP8
canonical
ensembl
ENSMUSG00000029458
resolver
ensp
ENSMUSP00000031414
resolver
ensp
ENSMUSP00000107395
resolver
genesymbol
Brap
resolver
uniprot
Q8CC00
resolver
uniprot
Q8CHX1
resolver
uniprot
Q99MP7
resolver
uniprot
Q9CXX8
resolver
uniprot_entry
BRAP_MOUSE
resolver
uniprot_sec
Q8CC00
resolver
uniprot_sec
Q8CHX1
resolver
uniprot_sec
Q99MP7
resolver
uniprot_sec
Q9CXX8
resolver
amino_acid_sequence
MSVSLVVIRLELAGHSPVPTDFGFSAAAGEMSDEEIKKKTLASAVACLEGKSAGEKAAIIHQHLGRREMTDVIIETMKARADEVRDTVEEKKPSAAPVSAQRSREQSESVNTAPESPSKQLPDQISFFSGNPSVEIVHGIMHLYKTNKMTSLKEDVRRSAMLCVLTVPATMTSHDLMKFVAPFNDVIEQMKIIRDSTPNQYMVLIKFSAQADADSFYMACNGRQFNSIEDDVCQLVYVERAEVLKSEDGASLPVMDLTELPKCTVCLERMDESVNGILTTLCNHSFHSQCLQRWDDTTCPVCRYCQTPEPVEENKCFECGVQENLWICLICGHIGCGRYVSRHAYKHFEETQHTYAMQLTNHRVWDYAGDNYVHRLVASKTDGKIVQYECEGDTCQEEKIDALQLEYSYLLTSQLESQRIYWENKIVRIEKDTAEEINNMKTKFKETIEKCDSLELRLSDLLKEKQSVERKCTQLNTRVAKLSTELQEEQELNKCLRANQLVLQNQLKEEEKLLKETCAQKDLQITEIQEQLRDVMFYLETQQQISHLPAETRQEIQEGQINIAMASAPNPPSSGAGGKLQSRKGRSKRGK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport (By similarity). {ECO:0000250|UniProtKB:Q7Z569}.
uniprot
proteins
mass_dalton
66991
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
14607334
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7Z569}.
uniprot
proteins