ARHH
entrez
399
canonical
uniprot
Q15669
canonical
ensembl
ENSG00000168421
resolver
ensp
ENSP00000371219
resolver
ensp
ENSP00000420866
resolver
ensp
ENSP00000422241
resolver
ensp
ENSP00000423384
resolver
ensp
ENSP00000425010
resolver
ensp
ENSP00000426439
resolver
ensp
ENSP00000478248
resolver
ensp
ENSP00000514769
resolver
ensp
ENSP00000514770
resolver
ensp
ENSP00000514771
resolver
ensp
ENSP00000514772
resolver
ensp
ENSP00000514773
resolver
ensp
ENSP00000514774
resolver
ensp
ENSP00000514775
resolver
ensp
ENSP00000578217
resolver
ensp
ENSP00000578218
resolver
ensp
ENSP00000578219
resolver
ensp
ENSP00000578220
resolver
ensp
ENSP00000578221
resolver
ensp
ENSP00000578222
resolver
ensp
ENSP00000578223
resolver
ensp
ENSP00000589464
resolver
ensp
ENSP00000589465
resolver
ensp
ENSP00000589466
resolver
ensp
ENSP00000632375
resolver
ensp
ENSP00000632376
resolver
enst
ENST00000381799
resolver
enst
ENST00000503754
resolver
enst
ENST00000503941
resolver
enst
ENST00000503978
resolver
enst
ENST00000505618
resolver
enst
ENST00000507851
resolver
enst
ENST00000508513
resolver
enst
ENST00000511121
resolver
enst
ENST00000511967
resolver
enst
ENST00000513894
resolver
enst
ENST00000515503
resolver
enst
ENST00000515702
resolver
enst
ENST00000515718
resolver
enst
ENST00000614836
resolver
enst
ENST00000908158
resolver
enst
ENST00000908159
resolver
enst
ENST00000908160
resolver
enst
ENST00000908161
resolver
enst
ENST00000908162
resolver
enst
ENST00000908163
resolver
enst
ENST00000908164
resolver
enst
ENST00000919405
resolver
enst
ENST00000919406
resolver
enst
ENST00000919407
resolver
enst
ENST00000962316
resolver
enst
ENST00000962317
resolver
genesymbol
ARHH
resolver
genesymbol
RHOH
resolver
genesymbol_syn
ARHH
resolver
genesymbol_syn
RHOH
resolver
genesymbol_syn
TTF
resolver
hgnc
HGNC:686
resolver
uniprot
A0A024R9S8
resolver
uniprot
Q6ICP4
resolver
uniprot_entry
Q6ICP4_HUMAN
resolver
uniprot_entry
RHOH_HUMAN
resolver
uniprot_sec
A0A024R9S8
resolver
amino_acid_sequence
MLSSIKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVDVFMDGIQISLGLWDTAGNDAFRSIRPLSYQQADVVLMCYSVANHNSFLNLKNKWIGEIRSNLPCTPVLVVATQTDQREMGPHRASCVNAMEGKKLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARRRNRRRLFSINECKIF
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving RHOH is found in a non-Hodgkin lymphoma cell line. Translocation t(3;4)(q27;p11) with BCL6.; DISEASE: Immunodeficiency 129 (IMD129) [MIM:618307]: An autosomal recessive immunologic disorder characterized by recurrent bacterial, viral, and fungal infections beginning in the first or second decades of life. Some patients have an abnormal susceptibility to infection by specific human papillomaviruses, including the oncogenic HPV5. Infection leads to the early development of disseminated flat wart-like and pityriasis versicolor-like skin lesions. Cutaneous Bowen's carcinomas in situ and invasive squamous cell carcinomas develop in about half of the patients, mainly on sun-exposed skin areas. Affected individuals have decreased number of naive T cells, increased memory and effector T cells, and impaired T-cell receptor signaling. {ECO:0000269|PubMed:22850876}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils. {ECO:0000250, ECO:0000269|PubMed:11809807, ECO:0000269|PubMed:19414807, ECO:0000269|PubMed:22850876}.
uniprot
proteins
mass_dalton
21331
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine by LCK. Phosphorylated by FYN. Phosphorylation enhances the interactions with ZAP70 and SYK and is critical for its function in thymocyte development (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Rho family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11809807
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17064668
uniprot
proteins
pubmed
19414807
uniprot
proteins
pubmed
22850876
uniprot
proteins
pubmed
7784061
uniprot
proteins
sequence_length
191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11809807, ECO:0000269|PubMed:19414807}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes together with ZAP70 in the immunological synapse. {ECO:0000250}.
uniprot
proteins