Phf2
entrez
18676
canonical
uniprot
Q9WTU0
canonical
ensembl
ENSMUSG00000038025
resolver
ensp
ENSMUSP00000047308
resolver
enst
ENSMUST00000035540
resolver
genesymbol
Phf2
resolver
genesymbol_syn
Kiaa0662
resolver
uniprot
Q6A023
resolver
uniprot
Q80WA8
resolver
uniprot_entry
PHF2_MOUSE
resolver
uniprot_sec
Q6A023
resolver
uniprot_sec
Q80WA8
resolver
activity_regulation
ACTIVITY REGULATION: Enzymatically inactive by itself, and become active following phosphorylation by PKA. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGPTPDVKPVQNGSQLFIKELRSRTFPSAEDVVSRVPGSQLTVGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIRPASANISLYERWRSASNHSEMFFADQVDRCYKCTVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFRPSQLIKDLAKEIRLSENASKTVRPEVNAAASSDEVCDGDREKEEPPSPVETTPPRSLLEKVSKKKTSKTVKMPKPSKIPKPPKSPKPPKTLKLKDGSKKKGKKCKESASPTIPNLDLLEAHTKEALTKMEPPKKGKTPKSVLSVPNKDTVHTQNDMERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQRLEKSPLAGNKDKFSFSFSNRKLLGSKALRPPSSPGVFGALQSFKEDKAKPVRDEYEYVSDDGELKIDEFPIRRKKSAPKRDLSFLLDKKEALLMPTSKPKLDSAVYKSDDSSDEGSLHIDTDTKPGRNAKVKKESGSSAAGILDLLQASEEVGALEYNPNSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGTGQAKGGSLAAHGARKIGGGNKGTGKRLLKRTAKNSVDLEDYEEQDHLDACFKDSDYVYPSLESDEDNPVFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKNRKKKNTKRKPAPNTASPSISTSASASTGTTSASTTPASTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSSLADHEYTAAGTFSGSQAGRASQPMAPGVFLTQRRPSASSPNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
function
FUNCTION: Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:22921934). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (PubMed:22921934). {ECO:0000250|UniProtKB:O75151, ECO:0000269|PubMed:22921934}.
uniprot
proteins
mass_dalton
120814
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA on specific serine residues, leading to the formation of an active lysine demethylase complex. {ECO:0000250}.
uniprot
proteins
protein_family
JHDM1 histone demethylase family
uniprot
proteins
protein_family
JHDM1D subfamily
uniprot
proteins
pubmed
10051327
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20129925
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22921934
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
1096
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:O75151}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:O75151}.
uniprot
proteins