Ptges2
entrez
96979
canonical
uniprot
Q8BWM0
canonical
ensembl
ENSMUSG00000026820
resolver
ensp
ENSMUSP00000028162
resolver
enst
ENSMUST00000028162
resolver
genesymbol
Ptges2
resolver
genesymbol_syn
Gbf1
resolver
genesymbol_syn
Pges2
resolver
uniprot
A2ASQ2
resolver
uniprot
Q99J30
resolver
uniprot_entry
PGES2_MOUSE
resolver
uniprot_sec
A2ASQ2
resolver
uniprot_sec
Q99J30
resolver
activity_regulation
ACTIVITY REGULATION: Isomerase activity is increased by sulfhydril compounds. Dithiothreitol (DTT) is most effective, followed by glutathione (GSH) and 2-mercaptoethanol. {ECO:0000250|UniProtKB:Q66LN0}.
uniprot
proteins
amino_acid_sequence
MAQAARLSWVLVSSRCALTEGLLTRPWQPLSAQSRAGFTRVAAGSRGAAVRKGSPRLLGAAALALGGALGLYHTVRWHQRSQDLRAERSAAQLPLSNSLQLTLYQYKTCPFCSKVRAFLDFHSLPYQVVEVNPVRRTEIKFSSYRKVPILVAQEGDSLQQLNDSSVIISALKTYLVSGQPLEEVITYYPPMKAMNDQGKEVTEFCNKYWLMLDEKEAQQMYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPAEALASFDYIVREGKFGAVEAAMAKYVGAAAMYLISKRLKSRHHLQDDVRVDLYEAANKWVTAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLEAFDDLMRHSHIQPWYLRMERAIEEAPSVHHVNPSCKD
uniprot
proteins
ec_number
5.3.99.3
uniprot
proteins
function
FUNCTION: Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate (By similarity). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity). May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear (PubMed:12050152). {ECO:0000250|UniProtKB:Q9H7Z7, ECO:0000250|UniProtKB:Q9N0A4, ECO:0000303|PubMed:12050152}.
uniprot
proteins
mass_dalton
43324
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; prostaglandin biosynthesis.
uniprot
proteins
post_translational_modification
PTM: Synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme. {ECO:0000250|UniProtKB:Q9H7Z7}.
uniprot
proteins
protein_family
GST superfamily
uniprot
proteins
pubmed
12050152
uniprot
proteins
pubmed
12835322
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15584915
uniprot
proteins
pubmed
15879117
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19010439
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25076362
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9H7Z7}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9H7Z7}. Nucleus {ECO:0000269|PubMed:12050152}. Note=According to PubMed:12050152, some fraction may be nuclear. {ECO:0000269|PubMed:12050152}.; SUBCELLULAR LOCATION: [Prostaglandin E synthase 2 truncated form]: Cytoplasm {ECO:0000250|UniProtKB:Q9H7Z7}. Note=Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. {ECO:0000250|UniProtKB:Q9H7Z7}.
uniprot
proteins
transmembrane_region
TRANSMEM 57..73; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins