Enpp1
entrez
85496
canonical
uniprot
Q924C3
canonical
ensembl
ENSRNOG00000013994
resolver
ensp
ENSRNOP00000019519
resolver
enst
ENSRNOT00000019519
resolver
genesymbol
Enpp1
resolver
genesymbol_syn
Npps
resolver
genesymbol_syn
Pc1
resolver
genesymbol_syn
Pdnp1
resolver
uniprot
G3V7V4
resolver
uniprot
Q91XQ3
resolver
uniprot
Q920C8
resolver
uniprot_entry
ENPP1_RAT
resolver
uniprot_entry
G3V7V4_RAT
resolver
uniprot_sec
Q91XQ3
resolver
uniprot_sec
Q920C8
resolver
activity_regulation
ACTIVITY REGULATION: At low concentrations of ATP, a phosphorylated intermediate is formed which inhibits further hydrolysis. {ECO:0000250|UniProtKB:P06802}.
uniprot
proteins
amino_acid_sequence
MERDGEQAGQGPRHGPAGNGRELESPAAASLLAPMDLGEEPLEKAERARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFSNCRCDAACVSLGNCCLDFQETCVEPTHIWTCNKFRCGEKRLSRFVCSCADDCKAHNDCCINYSSVCQEKKSWVEEACETIDAPQCPAEFESPPTLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTANHQEVRSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWLQLPSYERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLNLILISDHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTEVPETYYSFNYEALAKNLSCRETNQHFRPYLKHFLPKRLHFAKNDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNLFSNMQALFIGYGPAFKHGAEVDSFENIEVYNLMCDLLGLIPAPNNESHGSLNHLLKKPIYTPSHPKEESFLSQCPIKSVSSDLGCTCDPSIVPIMDFEKQFNLTTDAVEDVYSMTVPNGRPRNLQKQHRVCLLHQQQFLTGYSLDLLMPLWTSYTFLSNDQFSTDDFSNCLYQDLRIPLSPMHKCSYYKSTSKLSYGFLTPPRLNRVSRQIYSEALLTSNIVPMYQSFQVIWQYLHDTVLRRYAQERNGVNVVSGPVFDFDYDGRYDSSEILKQNTRVIRSQENLIPTHFFIVLTSCKQLSESPLKCTALESSAFLLPHRPDNIESCTHGKQESAWVEELLALHRARVTDVELITGLSFYQDRQESVSELLRLKTHLPIFSQED
uniprot
proteins
ec_number
3.1.4.1
uniprot
proteins
ec_number
3.6.1.9
uniprot
proteins
function
FUNCTION: Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels. PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP and UTP to their corresponding monophosphates with release of pyrophosphate, as well as diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling; it is however unclear whether hedgehog inhibition is direct or indirect (By similarity). Appears to modulate insulin sensitivity. Also involved in melanogenesis (By similarity). Also able to hydrolyze 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production (By similarity). 2',3'-cGAMP degradation takes place in the lumen or extracellular space, and not in the cytosol where it is produced; the role of 2',3'-cGAMP hydrolysis is therefore unclear. Not able to hydrolyze the 2',3'-cGAMP linkage isomer 3'-3'-cGAMP (By similarity). {ECO:0000250|UniProtKB:P06802, ECO:0000250|UniProtKB:P22413}.
uniprot
proteins
mass_dalton
102942
uniprot
proteins
post_translational_modification
PTM: The secreted form is produced through cleavage at Lys-85 by intracellular processing. {ECO:0000250|UniProtKB:P06802}.
uniprot
proteins
protein_family
Nucleotide pyrophosphatase/phosphodiesterase family
uniprot
proteins
pubmed
12121276
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
906
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Ectonucleotide pyrophosphatase/phosphodiesterase family member 1]: Cell membrane {ECO:0000250|UniProtKB:P06802}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P06802}. Basolateral cell membrane {ECO:0000250|UniProtKB:P06802}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P06802}. Note=Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. {ECO:0000250|UniProtKB:P06802}.; SUBCELLULAR LOCATION: [Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]: Secreted {ECO:0000250|UniProtKB:P06802}. Note=Secreted following proteolytic cleavage. {ECO:0000250|UniProtKB:P06802}.
uniprot
proteins
transmembrane_region
TRANSMEM 59..79; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins