RGMB
entrez
285704
canonical
uniprot
Q6NW40
canonical
ensembl
ENSG00000174136
resolver
ensp
ENSP00000308219
resolver
ensp
ENSP00000423256
resolver
ensp
ENSP00000564623
resolver
ensp
ENSP00000564624
resolver
ensp
ENSP00000564625
resolver
ensp
ENSP00000564626
resolver
ensp
ENSP00000564627
resolver
ensp
ENSP00000564628
resolver
ensp
ENSP00000564629
resolver
ensp
ENSP00000564630
resolver
ensp
ENSP00000564631
resolver
ensp
ENSP00000599859
resolver
ensp
ENSP00000599860
resolver
ensp
ENSP00000599861
resolver
ensp
ENSP00000599862
resolver
ensp
ENSP00000617768
resolver
ensp
ENSP00000617769
resolver
ensp
ENSP00000617770
resolver
enst
ENST00000308234
resolver
enst
ENST00000513185
resolver
enst
ENST00000894564
resolver
enst
ENST00000894565
resolver
enst
ENST00000894566
resolver
enst
ENST00000894567
resolver
enst
ENST00000894568
resolver
enst
ENST00000894569
resolver
enst
ENST00000894570
resolver
enst
ENST00000894571
resolver
enst
ENST00000894572
resolver
enst
ENST00000929800
resolver
enst
ENST00000929801
resolver
enst
ENST00000929802
resolver
enst
ENST00000929803
resolver
enst
ENST00000947709
resolver
enst
ENST00000947710
resolver
enst
ENST00000947711
resolver
genesymbol
RGMB
resolver
hgnc
HGNC:26896
resolver
uniprot
D6R9A0
resolver
uniprot
J3KNF6
resolver
uniprot
Q8NC92
resolver
uniprot_entry
J3KNF6_HUMAN
resolver
uniprot_entry
RGMB_HUMAN
resolver
uniprot_sec
D6R9A0
resolver
uniprot_sec
Q8NC92
resolver
amino_acid_sequence
MGLRAAPSSAAAAAAEVEQRRSPGLCPPPLELLLLLLFSLGLLHAGDCQQPAQCRIQKCTTDFVSLTSHLNSAVDGFDSEFCKALRAYAGCTQRTSKACRGNLVYHSAVLGISDLMSQRNCSKDGPTSSTNPEVTHDPCNYHSHAGAREHRRGDQNPPSYLFCGLFGDPHLRTFKDNFQTCKVEGAWPLIDNNYLSVQVTNVPVVPGSSATATNKITIIFKAHHECTDQKVYQAVTDDLPAAFVDGTTSGGDSDAKSLRIVERESGHYVEMHARYIGTTVFVRQVGRYLTLAIRMPEDLAMSYEESQDLQLCVNGCPLSERIDDGQGQVSAILGHSLPRTSLVQAWPGYTLETANTQCHEKMPVKDIYFQSCVFDLLTTGDANFTAAAHSALEDVEALHPRKERWHIFPSSGNGTPRGGSDLSVSLGLTCLILIVFL
uniprot
proteins
function
FUNCTION: Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth. {ECO:0000250|UniProtKB:Q7TQ33, ECO:0000269|PubMed:19324014}.
uniprot
proteins
mass_dalton
47547
uniprot
proteins
mutagenesis
MUTAGEN 186; /note="A->R: Severely impairs interaction with NEO1."; /evidence="ECO:0000269|PubMed:23744777"; MUTAGEN 206; /note="P->N: Introduces a N-linked glycan; changes interaction with NEO1 from a 2:2 to a 1:1 stoichiometry."; /evidence="ECO:0000269|PubMed:23744777
uniprot
proteins
post_translational_modification
PTM: GPI-anchored. {ECO:0000250|UniProtKB:Q7TQ33}.; PTM: Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds. {ECO:0000269|PubMed:23744777}.
uniprot
proteins
protein_family
Repulsive guidance molecule (RGM) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19324014
uniprot
proteins
pubmed
23744777
uniprot
proteins
sequence_length
437
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7TQ33}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q7TQ33}. Membrane raft {ECO:0000250|UniProtKB:Q7TQ33}.
uniprot
proteins