RNF34
entrez
80196
canonical
uniprot
Q969K3
canonical
ensembl
ENSG00000170633
resolver
ensp
ENSP00000355137
resolver
ensp
ENSP00000376258
resolver
ensp
ENSP00000477987
resolver
enst
ENST00000613529
resolver
genesymbol
RNF34
resolver
hgnc
HGNC:17297
resolver
uniprot
A0A087WTM5
resolver
uniprot
B7Z933
resolver
uniprot
Q8NG47
resolver
uniprot
Q9H6W8
resolver
uniprot_entry
A0A087WTM5_HUMAN
resolver
uniprot_entry
RNF34_HUMAN
resolver
uniprot_sec
B7Z933
resolver
uniprot_sec
Q8NG47
resolver
uniprot_sec
Q9H6W8
resolver
amino_acid_sequence
MKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGPFRFTPNPEFSTYPPAATEGPNIVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLKVKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMDTSSLNSSRSQTSSFFTRSFFSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQSEITSANTEDDDDDDDEDDDDEEENAEDRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRLYKENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219). {ECO:0000269|PubMed:12118383, ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:15897238, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:22064484, ECO:0000269|PubMed:25012219, ECO:0000269|Ref.13, ECO:0000303|PubMed:18382127}.
uniprot
proteins
mass_dalton
41641
uniprot
proteins
mutagenesis
MUTAGEN 328; /note="C->A: Loss of E3 ubiquitin protein ligase activity."; /evidence="ECO:0000303|PubMed:22064484"; MUTAGEN 342; /note="H->A: Loss of E3 ubiquitin protein ligase activity."; /evidence="ECO:0000269|PubMed:15069192
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|Ref.13}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated (in vitro). {ECO:0000250|UniProtKB:Q6AYH3}.; PTM: Proteolytically cleaved by caspases upon induction of apoptosis by TNF. {ECO:0000269|PubMed:12118383}.
uniprot
proteins
pubmed
12118383
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15069192
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15897238
uniprot
proteins
pubmed
17121812
uniprot
proteins
pubmed
18382127
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22064484
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25012219
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15069192}; Peripheral membrane protein {ECO:0000305}. Endomembrane system {ECO:0000250|UniProtKB:Q6AYH3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6AYH3}. Nucleus {ECO:0000269|PubMed:22064484}. Nucleus speckle {ECO:0000269|PubMed:12118383}. Cytoplasm, cytosol {ECO:0000269|PubMed:15069192}.
uniprot
proteins