P70248
uniprot
P70248
canonical
amino_acid_sequence
MGSKERFHWQSHNVKQSGVDDMVLLSQITEDAIVRNLHKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGAVQYEEPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGDKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQQQNLGIMSQDYYYYLNQSDTYKVEGTDDRSDFSETLSAMQVMGFRQACQQLVLQLVAGILHLGNISFCEEGNYARVESVDSLAFPAYLLGIDSGRLQEKLTSRKMDSKWGGRSESIDVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQSSDQDFLRMLFPEKLNIDKKGRPSTAGSKIKKQANDLVSTLKKCTPHYIRCIKPNETKRPRDWEESRVKHQVEYLGLRENIRVRRAGFAYRRQFSKFLQRYAILTPETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEMRERKFDGFARTIQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINRNFVGNYLGLEERPELRQFLAKRERVDFADSVTKYDRRFKPIKRDLILTPKCVYVIGTEKVKRGPEKGLVREVLKKKLDIQALRGVSLSTRQDDFFILQEEAADTFLESIFKTEFVSLLCKRFEEAARRPLPLTFQDILQFRVKKKGWGGGGTRNVTFSAGQVNLAVLKAGGKTLTISLGDGLPKNSKPTRKGLAQGKPRRSAQAPTRAVPWASQGLNRNGATLFPRGEGPYTLEIYIWPQEFPEASTAIHLQPQDASRRPRARPPSEHSTEFLNVPDQGVAGMQRKRSIGQRPVPASRPKPQPRTHGPRCRALYQYIGQDVDELSFNVNEVIEILIEDSSGWWKGRLHGQEGLFPGNYVEKI
uniprot
proteins
function
FUNCTION: Molecular adapter required for the movement of immune cells, such as mast cells, neutrophils and T-cells, to sites of inflammation or infection (PubMed:17023661, PubMed:29487067). Acts as a regulator of antifungal immunity in macrophages by acting as a molecular adapter between ATAT1 and alpha-tubulin, promoting alpha-tubulin acetylation and antifungal immune response (By similarity). Also acts as a positive regulator of cGAS-STING signaling by promoting plasma membrane localization of CGAS: following phosphorylation by SYK, acts as an molecular adapter by recruiting KAT2A to CGAS at the plasma membrane, leading to CGAS acetylation and activation (By similarity). {ECO:0000250|UniProtKB:O00160, ECO:0000269|PubMed:17023661, ECO:0000269|PubMed:29487067}.
uniprot
proteins
mass_dalton
125947
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Tyr-607 and Tyr-634 by SYK at the plasma membrane, promoting recruitment of KAT2A and acetylation of CGAS. {ECO:0000250|UniProtKB:O00160}.
uniprot
proteins
protein_family
Myosin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
17023661
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29487067
uniprot
proteins
pubmed
9119401
uniprot
proteins
sequence_length
1099
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17023661}. Cell membrane {ECO:0000250|UniProtKB:O00160}; Peripheral membrane protein {ECO:0000250|UniProtKB:O00160}.
uniprot
proteins