SIGLEC7
entrez
27036
canonical
uniprot
Q9Y286
canonical
ensembl
ENSG00000168995
resolver
ensp
ENSP00000306757
resolver
ensp
ENSP00000323328
resolver
ensp
ENSP00000472529
resolver
ensp
ENSP00000550973
resolver
ensp
ENSP00000656092
resolver
ensp
ENSP00000707944
resolver
genesymbol
SIGLEC7
resolver
genesymbol_syn
AIRM1
resolver
hgnc
HGNC:10876
resolver
uniprot
Q9NZQ1
resolver
uniprot
Q9UJ86
resolver
uniprot
Q9UJ87
resolver
uniprot
Q9Y502
resolver
uniprot_entry
SIGL7_HUMAN
resolver
uniprot_sec
Q9NZQ1
resolver
uniprot_sec
Q9UJ86
resolver
uniprot_sec
Q9UJ87
resolver
uniprot_sec
Q9Y502
resolver
amino_acid_sequence
MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDPVHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEKGNIKWNYKYDQLSVNVTALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPSNPLVLELQVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGGAGATALVFLSFCVIFIVVRSCRKKSARPAADVGDIGMKDANTIRGSASQGNLTESWADDNPRHHGLAAHSSGEEREIQYAPLSFHKGEPQDLSGQEATNNEYSEIKIPK
uniprot
proteins
function
FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). {ECO:0000269|PubMed:10611343}.
uniprot
proteins
mass_dalton
51143
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated. {ECO:0000269|PubMed:10499918}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
SIGLEC (sialic acid binding Ig-like lectin) family
uniprot
proteins
pubmed
10499918
uniprot
proteins
pubmed
10567377
uniprot
proteins
pubmed
10611343
uniprot
proteins
pubmed
10764831
uniprot
proteins
pubmed
11389909
uniprot
proteins
pubmed
12438315
uniprot
proteins
pubmed
14747738
uniprot
proteins
pubmed
16623661
uniprot
proteins
pubmed
16895906
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 354..376; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins