B3gat1
entrez
117108
canonical
uniprot
O35789
canonical
ensembl
ENSRNOG00000007142
resolver
ensp
ENSRNOP00000009825
resolver
genesymbol
B3gat1
resolver
uniprot
A0A0H2UHF1
resolver
uniprot_entry
B3GA1_RAT
resolver
uniprot_sec
A0A0H2UHF1
resolver
amino_acid_sequence
MPKRRDILAIVLIVLPWTLLITVWHQSSLAPLLAVHKDEGSDPRHEAPPGADPREYCMSDRDIVEVVRTEYVYTRPPPWSDTLPTIHVVTPTYSRPVQKAELTRMANTLLHVPNLHWLVVEDAPRRTPLTARLLRDTGLNYTHLHVETPRNYKLRGDARDPRIPRGTMQRNLALRWLRETFPRNSTQPGVVYFADDDNTYSLELFEEMRSTRRVSVWPVAFVGGLRYEAPRVNGAGKVVGWKTVFDPHRPFAIDMAGFAVNLRLILQRSQAYFKLRGVKGGYQESSLLRELVTLNDLEPKAANCTKILVWHTRTEKPVLVNEGKKGFTDPSVEI
uniprot
proteins
ec_number
2.4.1.135
uniprot
proteins
function
FUNCTION: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. {ECO:0000269|PubMed:19181664, ECO:0000269|PubMed:9804790}.
uniprot
proteins
mass_dalton
38237
uniprot
proteins
mutagenesis
MUTAGEN 3..5; /note="KRR->AAA: Significantly disrupts Golgi apparatus localization. Decreases galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity. Impairs secretion and interaction with SAR1A."; /evidence="ECO:0000269|PubMed:19181664
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation.
uniprot
proteins
post_translational_modification
PTM: The soluble form derives from the membrane form by proteolytic processing. {ECO:0000269|PubMed:19181664}.
uniprot
proteins
protein_family
Glycosyltransferase 43 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
19181664
uniprot
proteins
pubmed
9177175
uniprot
proteins
pubmed
9804790
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus membrane {ECO:0000269|PubMed:19181664}; Single-pass type II membrane protein. Secreted {ECO:0000269|PubMed:19181664}.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus membrane {ECO:0000269|PubMed:19181664}; Single-pass type II membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19181664}. Secreted {ECO:0000269|PubMed:19181664}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins