Boc
entrez
117606
canonical
uniprot
Q6AZB0
canonical
ensembl
ENSMUSG00000022687
resolver
ensp
ENSMUSP00000110281
resolver
enst
ENSMUST00000114634
resolver
genesymbol
Boc
resolver
uniprot
D3Z763
resolver
uniprot
Q6KAM5
resolver
uniprot
Q6P5H3
resolver
uniprot
Q7TMJ3
resolver
uniprot
Q8CE73
resolver
uniprot
Q8CE91
resolver
uniprot
Q8R377
resolver
uniprot
Q923W7
resolver
uniprot_entry
BOC_MOUSE
resolver
uniprot_entry
D3Z763_MOUSE
resolver
uniprot_sec
Q6KAM5
resolver
uniprot_sec
Q6P5H3
resolver
uniprot_sec
Q7TMJ3
resolver
uniprot_sec
Q8CE73
resolver
uniprot_sec
Q8CE91
resolver
uniprot_sec
Q8R377
resolver
uniprot_sec
Q923W7
resolver
amino_acid_sequence
MTTCRRERPILTLLWILMATAGCLADLNEVPQVTVQPMSTVQKLGGTVILGCVVEPPWMNVTWRFNGKELNGSDDALGVFITRGTLVIAALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRDNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSGDRLRVRRSTAEAARIIYPLEAQTVIVTKGQSLILECVASGIPPPRVTWAKDGSSIAAYNKTRFLLSNLLIDTTSEEDSGTYRCMASNGVGDPGAAVILYNVQVFEPPEVTVELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLTSSQRLRLSRRALRVVSVGPEDEGVYQCMAENAVGSAHAVVQLRTARPDTTLRPGRDTKPIAATPPMPPSRPSRPDQMLREQPGLVKPPTSSVQPTSLKCPGEEQVAPAEAPIILSSPRTSKTDSYELVWRPRHEGSSRTPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIVASKEQQIQRDDPGASLQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGISYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDRYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKFSGQPGRPPPLTLAPPQPPPLETMERPVGTGAMVARASDLPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALLSSSCQYTMVPLEGLPGHQANGQPYLGGVSGRACVSRVHGSRGCPAATVGCPGRKPQQHCPGELAQQREDTNSQLRQPIVSNGYDLQNQQVARGPQCASGVGAFLYTLPDDSTHQLLQPQDCCHLQKQPVTTCQTAVRRTSESPGLESSWDPPYHSGPRCCLGLVPVEEVDSSDSCQVGGGDWSSQHPSGTYTGQERGMRFSPSPSVHVSFETPPPTI
uniprot
proteins
function
FUNCTION: Together with CDON, forms a coreceptor required for sonic hedgehog (SHH) handoff to its patched receptor (PTCH1 or PTCH2), thereby allowing activation of the smoothened signaling pathway (PubMed:16647303, PubMed:16647304, PubMed:17086203, PubMed:21664576, PubMed:33038332). Binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) downstream of SCUBE2 carrier and promotes its release to GAS1 (PubMed:33038332). ShhN is then directly transferred to patched receptor by GAS1 (PubMed:33038332). May also mediate cell-cell interactions between muscle precursor cells, promoting differentiation of myogenic cells (PubMed:11782431, PubMed:12634428, PubMed:15520228). {ECO:0000269|PubMed:11782431, ECO:0000269|PubMed:12634428, ECO:0000269|PubMed:15520228, ECO:0000269|PubMed:16647303, ECO:0000269|PubMed:16647304, ECO:0000269|PubMed:17086203, ECO:0000269|PubMed:21664576, ECO:0000269|PubMed:33038332}.
uniprot
proteins
mass_dalton
121331
uniprot
proteins
pubmed
11782431
uniprot
proteins
pubmed
12634428
uniprot
proteins
pubmed
15449545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15520228
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16647303
uniprot
proteins
pubmed
16647304
uniprot
proteins
pubmed
17086203
uniprot
proteins
pubmed
21664576
uniprot
proteins
pubmed
33038332
uniprot
proteins
sequence_length
1110
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BWV1}; Single-pass type I membrane protein {ECO:0000255}. Note=Enriched at sites of cell-cell contact. {ECO:0000250|UniProtKB:Q9BWV1}.
uniprot
proteins
transmembrane_region
TRANSMEM 851..871; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins