N4BP3
entrez
23138
canonical
uniprot
O15049
canonical
ensembl
ENSG00000145911
resolver
ensp
ENSP00000274605
resolver
ensp
ENSP00000520954
resolver
ensp
ENSP00000548644
resolver
ensp
ENSP00000548645
resolver
ensp
ENSP00000548646
resolver
ensp
ENSP00000603320
resolver
ensp
ENSP00000603321
resolver
ensp
ENSP00000603322
resolver
ensp
ENSP00000603323
resolver
ensp
ENSP00000603324
resolver
ensp
ENSP00000603325
resolver
ensp
ENSP00000603326
resolver
ensp
ENSP00000603327
resolver
ensp
ENSP00000603328
resolver
ensp
ENSP00000603329
resolver
ensp
ENSP00000632474
resolver
ensp
ENSP00000632475
resolver
enst
ENST00000274605
resolver
enst
ENST00000850869
resolver
enst
ENST00000878585
resolver
enst
ENST00000878586
resolver
enst
ENST00000878587
resolver
enst
ENST00000933261
resolver
enst
ENST00000933262
resolver
enst
ENST00000933263
resolver
enst
ENST00000933264
resolver
enst
ENST00000933265
resolver
enst
ENST00000933266
resolver
enst
ENST00000933267
resolver
enst
ENST00000933268
resolver
enst
ENST00000933269
resolver
enst
ENST00000933270
resolver
enst
ENST00000962415
resolver
enst
ENST00000962416
resolver
genesymbol
N4BP3
resolver
genesymbol_syn
KIAA0341
resolver
hgnc
HGNC:29852
resolver
uniprot
B4DIL3
resolver
uniprot
D3DWP3
resolver
uniprot
Q6ZSQ6
resolver
uniprot
Q7Z6I3
resolver
uniprot_entry
N4BP3_HUMAN
resolver
uniprot_sec
B4DIL3
resolver
uniprot_sec
D3DWP3
resolver
uniprot_sec
Q6ZSQ6
resolver
uniprot_sec
Q7Z6I3
resolver
amino_acid_sequence
MATAPGPAGIAMGSVGSLLERQDFSPEELRAALAGSRGSRQPDGLLRKGLGQREFLSYLHLPKKDSKSTKNTKRAPRNEPADYATLYYREHSRAGDFSKTSLPERGRFDKCRIRPSVFKPTAGNGKGFLSMQSLASHKGQKLWRSNGSLHTLACHPPLSPGPRASQARAQLLHALSLDEGGPEPEPSLSDSSSGGSFGRSPGTGPSPFSSSLGHLNHLGGSLDRASQGPKEAGPPAVLSCLPEPPPPYEFSCSSAEEMGAVLPETCEELKRGLGDEDGSNPFTQVLEERQRLWLAELKRLYVERLHEVTQKAERSERNLQLQLFMAQQEQRRLRKELRAQQGLAPEPRAPGTLPEADPSARPEEEARWEVCQKTAEISLLKQQLREAQAELAQKLAEIFSLKTQLRGSRAQAQAQDAELVRLREAVRSLQEQAPREEAPGSCETDDCKSRGLLGEAGGSEARDSAEQLRAELLQERLRGQEQALRFEQERRTWQEEKERVLRYQREIQGGYMDMYRRNQALEQELRALREPPTPWSPRLESSKI
uniprot
proteins
function
FUNCTION: Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}.
uniprot
proteins
mass_dalton
60470
uniprot
proteins
protein_family
N4BP3 family
uniprot
proteins
pubmed
11717310
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15324660
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
34880843
uniprot
proteins
pubmed
9205841
uniprot
proteins
sequence_length
544
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:11717310}. Cell projection, axon {ECO:0000250|UniProtKB:Q3LUD3}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q3LUD3}. Note=In developing neurons, accumulates in early growth cones and at branching points of axons and dendrites. {ECO:0000250|UniProtKB:Q3LUD3}.
uniprot
proteins