Rrm2b
entrez
382985
canonical
uniprot
Q6PEE3
canonical
ensembl
ENSMUSG00000022292
resolver
ensp
ENSMUSP00000022901
resolver
ensp
ENSMUSP00000220942
resolver
ensp
ENSMUSP00000356313
resolver
enst
ENSMUST00000022901
resolver
genesymbol
Rrm2b
resolver
genesymbol_syn
P53r2
resolver
uniprot_entry
RIR2B_MOUSE
resolver
amino_acid_sequence
MGDPERPEAARPEKGEQLCSETEENVVRSNEEPLLRKSSRRFVIFPIQYPDIWRMYKQAQASFWTAEEVDLSKDLPHWNKLKSDEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEDRVREIIADAVQIEQEFLTEALPVGLIGMNCVLMKQYIEFVADRLLGELGFSKIFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF
uniprot
proteins
ec_number
1.17.4.1
uniprot
proteins
function
FUNCTION: Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. {ECO:0000269|PubMed:11517226, ECO:0000269|PubMed:12858174}.
uniprot
proteins
mass_dalton
40804
uniprot
proteins
protein_family
Ribonucleoside diphosphate reductase small chain family
uniprot
proteins
pubmed
11517226
uniprot
proteins
pubmed
12858174
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates from cytoplasm to nucleus in response to DNA damage. {ECO:0000250}.
uniprot
proteins