Lair1
entrez
52855
canonical
uniprot
Q8BG84
canonical
ensembl
ENSMUSG00000055541
resolver
ensp
ENSMUSP00000070712
resolver
ensp
ENSMUSP00000083589
resolver
ensp
ENSMUSP00000104241
resolver
ensp
ENSMUSP00000145940
resolver
ensp
ENSMUSP00000239144
resolver
genesymbol
Lair1
resolver
uniprot
Q80UN5
resolver
uniprot
Q8BHB6
resolver
uniprot
Q8BRR6
resolver
uniprot
Q8C6N8
resolver
uniprot
Q8CEP5
resolver
uniprot_entry
LAIR1_MOUSE
resolver
uniprot_sec
Q80UN5
resolver
uniprot_sec
Q8BHB6
resolver
uniprot_sec
Q8BRR6
resolver
uniprot_sec
Q8C6N8
resolver
uniprot_sec
Q8CEP5
resolver
amino_acid_sequence
MSLHPVILLVLVLCLGWKINTQEGSLPDITIFPNSSLMISQGTFVTVVCSYSDKHDLYNMVRLEKDGSTFMEKSTEPYKTEDEFEIGPVNETITGHYSCIYSKGITWSERSKTLELKVIKENVIQTPAPGPTSDTSWLKTYSIYIFTVVSVIFLLCLSALLFCFLRHRQKKQGLPNNKRQQQRPEERLNLATNGLEMTPDIVADDRLPEDRWTETWTPVAGDLQEVTYIQLDHHSLTQRAVGAVTSQSTDMAESSTYAAIIRH
uniprot
proteins
function
FUNCTION: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity). {ECO:0000250, ECO:0000269|PubMed:15100296}.
uniprot
proteins
mass_dalton
29793
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-228 and Tyr-257 activates it. May be phosphorylated by LCK (By similarity). {ECO:0000250}.; PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
15100296
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16380958
uniprot
proteins
sequence_length
263
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 145..165; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins