Trim3
entrez
83616
canonical
uniprot
O70277
canonical
ensembl
ENSRNOG00000018356
resolver
ensp
ENSRNOP00000024850
resolver
ensp
ENSRNOP00000084221
resolver
enst
ENSRNOT00000024850
resolver
genesymbol
Trim3
resolver
genesymbol_syn
Berp
resolver
genesymbol_syn
Rnf22
resolver
uniprot
G3V8D6
resolver
uniprot_entry
G3V8D6_RAT
resolver
uniprot_entry
TRIM3_RAT
resolver
amino_acid_sequence
MAKREDSPGPEVQPMDKQFLVCSICLDRYRCPKVLPCLHTFCERCLQNYIPPQSLTLSCPVCRQTSILPEQGVSALQNNFFISSLMEAMQQAPDGAHDPEDPHPLSAVAGRPLSCPNHEGKTMEFYCEACETAMCGECRAGEHREHGTVLLRDVVEQHKAALQRQLEAVRGRLPQLSAAIALVGGISQQLQERKAEALAQISAAFEDLEQALQQRKQALVSDLESICGAKQKVLQTQLDTLRQGQEHIGSSCSFAEQALRLGSAPEVLLVRKHMRERLAALAAQAFPERPHENAQLELVLEVDGLRRSVLNLGALLTTSAAAHETVATGEGLRQALVGQPASLTVTTKDKDGRLVRTGSAELCAEITGPDGMRLAVPVVDHKNGTYELVYTARTEGDLLLSVLLYGQPVRGSPFRVRALRPGDLPPSPDDVKRRVKSPGGPGSHVRQKAVRRPSSMYSTGGKRKDNPIVDELVFRVGSRGREKGEFTNLHPLSAASSGRIVVADSNNQCIQVFSNEGQFKFRFGVRGRSPGQLQRPTGVAVDTNGDIIVADYDNRWVSIFSPEGKFKTKIGAGRLMGPKGVAVDRNGHIIVVDNKSCCVFTFQPNGKLVGRFGGRGATDRHFAGPHFVAVNNKNEIVVTDFHNHSVKVYSADGEFLFKFGSHGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDSSGSFLSYINTSAEPLYGPQGLALTSDGHVVVADAGNHCFKAYRYLQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (PubMed:20352094). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (PubMed:20352094). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquitinates CDKN1A. Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3. In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (By similarity). {ECO:0000250|UniProtKB:O75382, ECO:0000250|UniProtKB:Q9R1R2, ECO:0000269|PubMed:20352094}.
uniprot
proteins
mass_dalton
80796
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="C->S: Strong loss of GKAP ubiquitination; when associated with S-25."; /evidence="ECO:0000269|PubMed:20352094"; MUTAGEN 25; /note="C->S: Strong loss of GKAP ubiquitination; when associated with S-22."; /evidence="ECO:0000269|PubMed:20352094
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
10391919
uniprot
proteins
pubmed
10673389
uniprot
proteins
pubmed
20352094
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
744
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O75382}. Early endosome {ECO:0000250|UniProtKB:O75382}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9R1R2}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9R1R2}. Note=Mainly located in the Golgi apparatus and transported to the early endosomes upon stimulation with dsRNA. {ECO:0000250|UniProtKB:O75382}.
uniprot
proteins