Nr2e3
entrez
23958
canonical
uniprot
Q9QXZ7
canonical
ensembl
ENSMUSG00000032292
resolver
ensp
ENSMUSP00000034831
resolver
enst
ENSMUST00000034831
resolver
genesymbol
Nr2e3
resolver
genesymbol_syn
Pnr
resolver
genesymbol_syn
Rnr
resolver
uniprot
Q543C7
resolver
uniprot_entry
NR2E3_MOUSE
resolver
uniprot_entry
Q543C7_MOUSE
resolver
amino_acid_sequence
MSSTVAASTMPVSVAASKKESPGRWGLGEDPTGVGPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSMAQVHLDAMETGSDPRSEPVVASPALAGPSPRGPTSVSATRAMGHHFMASLITAETCAKLEPEDAEENIDVTSNDPEFPASPCSLDGIHETSARLLFMAVKWAKNLPVFSNLPFRDQVILLEEAWNELFLLGAIQWSLPLDSCPLLAPPEASGSSQGRLALASAETRFLQETISRFRALAVDPTEFACLKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFLTAERIELLFFRKTIGNTPMEKLLCDMFKN
uniprot
proteins
function
FUNCTION: Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. {ECO:0000269|PubMed:15190009, ECO:0000269|PubMed:15634773, ECO:0000269|PubMed:19186166, ECO:0000269|PubMed:21408158}.
uniprot
proteins
mass_dalton
43177
uniprot
proteins
mutagenesis
MUTAGEN 178; /note="K->R: Greatly reduced levels of PIAS3-mediated sumoylation. Completely abolishes sumoylation; when associated with R-315 and R-322."; /evidence="ECO:0000269|PubMed:19186166"; MUTAGEN 315; /note="K->R: Little change in sumoylation. Completely abolishes sumoylation; when associated with R-178 and R-322."; /evidence="ECO:0000269|PubMed:19186166"; MUTAGEN 322; /note="K->R: Little change in sumoylation. Completely abolishes sumoylation; when associated with R-178 and R-315."; /evidence="ECO:0000269|PubMed:19186166
uniprot
proteins
post_translational_modification
PTM: Di- and tri-sumoylated in developing retina. PIAS3-mediated sumoylation promotes repression of cone-specific gene expression and activation of rod-specific genes. Sumoylation on Lys-178 appears to be the main site. {ECO:0000269|PubMed:19186166}.
uniprot
proteins
protein_family
NR2 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10611353
uniprot
proteins
pubmed
10805811
uniprot
proteins
pubmed
15190009
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15634773
uniprot
proteins
pubmed
19186166
uniprot
proteins
pubmed
21408158
uniprot
proteins
pubmed
28900001
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:15190009, ECO:0000269|PubMed:19186166}.
uniprot
proteins