Ppp1r15a
entrez
171071
canonical
uniprot
Q6IN02
canonical
genesymbol
Ppp1r15a
resolver
genesymbol_syn
Gadd34
resolver
genesymbol_syn
Myd116
resolver
genesymbol_syn
Peg3
resolver
uniprot
O88344
resolver
uniprot
Q7TQC2
resolver
uniprot_entry
PR15A_RAT
resolver
uniprot_sec
O88344
resolver
uniprot_sec
Q7TQC2
resolver
amino_acid_sequence
MAPSPRPQHVLHWKEAHSFYLLSPLMGFLSRAWSRLRGPEVSEAWLAETVAGANQIEADALLTPPPVSENHLPLRETEGNGTPEWSKAAQRLCLDVEAQSSPPKTWGLSDIDEHNGKPGQDGLREQEVEHTAGLPTLQPLHLQGADKKVGEVVAREEGVSELAYPTSHWEGGPAEDEEDTETVKKAHQASAASIAPGYKPSTSVYCPGEAEHRATEEKGTDNKAEPSGSHSRVWEYHTRERPKQEGETKPEQHRAGQSHPCQNAEAEEGGPETSVCSGSAFLKAWVYRPGEDTEEEEDSDLDSAEEDTAHTCTTPHTSAFLKAWVYRPGEDTEEEDDGDWDSAEEDASQSCTTPHTSAFLKAWVYRPGEDTEEEDDSENVAPVDSETVDSCQSTQHCLPVEKTKGCGEAEPPPFQVAFYLPGQKPAPPWAAPKLPLRLQKRLRSFKAPARNQDPEIPLKGRKVHFSEKVTVHFLAVWAGPAQAARRGPWEQFARDRSRFARRIAQAEEQLGPYLTPAFRARAWTRLRNLPLPLSSSSLPLPEPCSSTEATPLSQDVTTPSPLPSEIPPPSLDLGGRRG
uniprot
proteins
function
FUNCTION: Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux. Also acts a viral restriction factor by attenuating replication of some viruses. {ECO:0000250|UniProtKB:O75807, ECO:0000269|PubMed:15674324}.
uniprot
proteins
mass_dalton
63570
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at multiple Ser/Thr residues. Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity. Phosphorylation at Tyr-236 enhances proteasomal degradation, this position is dephosphorylated by PTPN2. {ECO:0000250|UniProtKB:O75807}.; PTM: Polyubiquitinated. Exhibits a rapid proteasomal degradation with a half-life under 1 hour, ubiquitination depends on endoplasmic reticulum association. {ECO:0000250|UniProtKB:O75807}.
uniprot
proteins
protein_family
PPP1R15 family
uniprot
proteins
pubmed
10611347
uniprot
proteins
pubmed
12813455
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15674324
uniprot
proteins
pubmed
8139541
uniprot
proteins
pubmed
9256446
uniprot
proteins
sequence_length
578
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:O75807}. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:O75807}. Note=Associates with membranes via an N-terminal amphipathic intramembrane region. {ECO:0000250|UniProtKB:O75807}.
uniprot
proteins