FAM193A
entrez
8603
canonical
uniprot
P78312
canonical
ensembl
ENSG00000125386
resolver
ensp
ENSP00000324587
resolver
ensp
ENSP00000372290
resolver
ensp
ENSP00000421200
resolver
ensp
ENSP00000427260
resolver
ensp
ENSP00000427505
resolver
ensp
ENSP00000490564
resolver
ensp
ENSP00000601558
resolver
ensp
ENSP00000694969
resolver
genesymbol
FAM193A
resolver
genesymbol_syn
C4orf8
resolver
hgnc
HGNC:16822
resolver
uniprot
A0A1B0GVL4
resolver
uniprot
B7ZM85
resolver
uniprot
B9EGR0
resolver
uniprot
E9PFA1
resolver
uniprot
O43607
resolver
uniprot
P78311
resolver
uniprot
P78313
resolver
uniprot
Q9UEG8
resolver
uniprot_entry
F193A_HUMAN
resolver
uniprot_sec
A0A1B0GVL4
resolver
uniprot_sec
B7ZM85
resolver
uniprot_sec
B9EGR0
resolver
uniprot_sec
E9PFA1
resolver
uniprot_sec
O43607
resolver
uniprot_sec
P78311
resolver
uniprot_sec
P78313
resolver
uniprot_sec
Q9UEG8
resolver
amino_acid_sequence
MSPADAKRGAKRRKNKRGGGGGSGGGNGGASSGKAGPAAALRGSQAAGLAAPGSAAGLVGGAAAANGPLGAGASAGGAAPGGYFETPFSFGMNHRTPPYPAGDYCLLCRSERKDSSFLESGIKTASKLALSMAPKGNSVLHLPLWVCPDCRRTVEKEERHGGLDQPVSQDFLLHSSLGGSQPEAGSGGRLALGAQTLPSDTACSCEACSERREISAEADREPQQLQNYWSEVRYTVRCIYRQAGTPLADDQDQSLVPDKEGVKELVDRLCERDPYQLYQRLEQQAREYVLEMKVRLLRQLSAAAKVKAPSGLQGPPQAHQFISLLLEEYGALCQAARSISTFLGTLENEHLKKFQVTWELHNKHLFENLVFSEPLLQSNLPALVSQIRLGTTTHDTCSEDTYSTLLQRYQRSEEELRRVAEEWLECQKRIDAYVDEQMTMKTKQRMLTEDWELFKQRRFIEEQLTNKKAVTGENNFTDTMRHMLSSRLSMPDCPNCNYRRRCACDDCSLSHILTCGIMDPPVTDDIHIHQLPLQVDPAPDYLAERSPPSVSSASSGSGSSSPITIQQHPRLILTDSGSAPTFCSDDEDVAPLSAKFADIYPLSNYDDTEVVANMNGIHSELNGGGENMALKDESPQISSTSSSSSEADDEEADGESSGEPPGAPKEDGVLGSRSPRTEESKADSPPPSYPTQQAEQAPNTCECHVCKQEASGLTPSAMTAGALPPGHQFLSPEKPTHPALHLYPHIHGHVPLHTVPHLPRPLIHPTLYATPPFTHSKALPPAPVQNHTNKHQVFNASLQDHIYPSCFGNTPEWNSSKFISLWGSEVMNDKNWNPGTFLPDTISGSEILGPTLSETRPEALPPPSSNETPAVSDSKEKKNAAKKKCLYNFQDAFMEANKVVMATSSATSSVSCTATTVQSSNSQFRVSSKRPPSVGDVFHGISKEDHRHSAPAAPRNSPTGLAPLPALSPAALSPAALSPASTPHLANLAAPSFPKTATTTPGFVDTRKSFCPAPLPPATDGSISAPPSVCSDPDCEGHRCENGVYDPQQDDGDESADEDSCSEHSSSTSTSTNQKEGKYCDCCYCEFFGHGGPPAAPTSRNYAEMREKLRLRLTKRKEEQPKKMDQISERESVVDHRRVEDLLQFINSSETKPVSSTRAAKRARHKQRKLEEKARLEAEARAREHLHLQEEQRRREEEEDEEEEEDRFKEEFQRLQELQKLRAVKKKKKERPSKDCPKLDMLTRNFQAATESVPNSGNIHNGSLEQTEEPETSSHSPSRHMNHSEPRPGLGADGDAADPVDTRDSKFLLPKEVNGKQHEPLSFFFDIMQHHKEGNGKQKLRQTSKASSEPARRPTEPPKATEGQSKPRAQTESKAKVVDLMSITEQKREERKVNSNNNNKKQLNHIKDEKSNPTPMEPTSPGEHQQNSKLVLAESPQPKGKNKKNKKKKGDRVNNSIDDVFLPKDIDLDSVDMDETEREVEYFKRFCLDSARQTRQRLSINWSNFSLKKATFAAH
uniprot
proteins
function
FUNCTION: Acts as a positive regulator of p53/TP53 by interacting with p53 repressors MDM2 and MDM4 and destabilizing MDM4 which leads to enhanced p53 transcriptional activity. {ECO:0000269|PubMed:36897777}.
uniprot
proteins
mass_dalton
166372
uniprot
proteins
protein_family
FAM193 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
36897777
uniprot
proteins
pubmed
9734812
uniprot
proteins
sequence_length
1515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:36897777}. Cytoplasm {ECO:0000269|PubMed:36897777}. Note=Localization is heterogeneous from cell to cell, ranging from mostly cytoplasmic to almost exclusively nuclear. {ECO:0000269|PubMed:36897777}.
uniprot
proteins