Tnfsf10
entrez
22035
canonical
uniprot
P50592
canonical
ensembl
ENSMUSG00000039304
resolver
ensp
ENSMUSP00000040271
resolver
enst
ENSMUST00000046383
resolver
genesymbol
Tnfsf10
resolver
genesymbol_syn
Trail
resolver
uniprot
Q3U5H0
resolver
uniprot_entry
Q3U5H0_MOUSE
resolver
uniprot_entry
TNF10_MOUSE
resolver
amino_acid_sequence
MPSSGALKDLSFSQHFRMMVICIVLLQVLLQAVSVAVTYMYFTNEMKQLQDNYSKIGLACFSKTDEDFWDSTDGEILNRPCLQVKRQLYQLIEEVTLRTFQDTISTVPEKQLSTPPLPRGGRPQKVAAHITGITRRSNSALIPISKDGKTLGQKIESWESSRKGHSFLNHVLFRNGELVIEQEGLYYIYSQTYFRFQEAEDASKMVSKDKVRTKQLVQYIYKYTSYPDPIVLMKSARNSCWSRDAEYGLYSIYQGGLFELKKNDRIFVSVTNEHLMDLDQEASFFGAFLIN
uniprot
proteins
function
FUNCTION: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. {ECO:0000250|UniProtKB:P50591}.
uniprot
proteins
mass_dalton
33477
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated by PKDCC/VLK. {ECO:0000250|UniProtKB:P50591}.
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
8777713
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P50591}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P50591}. Secreted {ECO:0000250|UniProtKB:P50591}. Note=Exists both as membrane-bound and soluble form. {ECO:0000250|UniProtKB:P50591}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins