Cfl2
entrez
12632
canonical
uniprot
P45591
canonical
ensembl
ENSMUSG00000062929
resolver
ensp
ENSMUSP00000077262
resolver
enst
ENSMUST00000078124
resolver
genesymbol
Cfl2
resolver
uniprot
Q3UHW9
resolver
uniprot_entry
COF2_MOUSE
resolver
uniprot_entry
Q3UHW9_MOUSE
resolver
amino_acid_sequence
MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIGDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGSVVVSLEGKPL
uniprot
proteins
function
FUNCTION: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere. {ECO:0000269|PubMed:11809832, ECO:0000269|PubMed:22343409, ECO:0000269|PubMed:24598388}.
uniprot
proteins
mass_dalton
18710
uniprot
proteins
post_translational_modification
PTM: The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.
uniprot
proteins
protein_family
Actin-binding proteins ADF family
uniprot
proteins
pubmed
11809832
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22343409
uniprot
proteins
pubmed
24598388
uniprot
proteins
pubmed
8195165
uniprot
proteins
sequence_length
166
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus matrix. Cytoplasm, cytoskeleton. Note=Colocalizes with CSPR3 in the Z line of sarcomeres. {ECO:0000250|UniProtKB:Q9Y281}.
uniprot
proteins