Trdn
entrez
76757
canonical
uniprot
E9Q9K5
canonical
ensembl
ENSMUSG00000019787
resolver
ensp
ENSMUSP00000093436
resolver
ensp
ENSMUSP00000151583
resolver
ensp
ENSMUSP00000152042
resolver
genesymbol
Trdn
resolver
uniprot
Q8VIN7
resolver
uniprot
Q8VIN8
resolver
uniprot
Q8VIN9
resolver
uniprot
Q9CV36
resolver
uniprot_entry
TRDN_MOUSE
resolver
uniprot_sec
Q8VIN7
resolver
uniprot_sec
Q8VIN8
resolver
uniprot_sec
Q8VIN9
resolver
uniprot_sec
Q9CV36
resolver
amino_acid_sequence
MTEITAEGNASTTTTVIDNKNGCIPKSPGKVLKRSVTEDIVTTFSSPAAWLLVIALIITWSAVAIVMFDLVDYKNFSASSIAKIGSDPLKLVNDAVEETTDWIYGFFSLLSDIISSEGDEDDEDADEDIDKGEIEEPPLKRKEIHQEKAEKEEKPEKKIQTKASHREREKGKEKLKGEKPEKTATHKEKLEKKERPETKMMAKEDKKIKTKEKTEEKAKKEMKVGKQEKVKPTAAKAKETPKTPPKARKKDDKEMPAVHEQKDQYAFCRYMIDMFVHGDLKPGQSPVMPPPSLTPSKPALSTTALEEKEKEEKKKMEKKDTSDTKKKEKEVKKKSEETTIDGKGKEPGKPPETKQMTAKLTTQAAARKDEKKEESKKMRKPTEEQPKGKKQEKKEKHIEPAKTPKKEHPGPSEKLKKAKAEQAKEEIAAASTKKALHGKKEEKAKTVEQEVKKEKSGKSSSDLKDKEVKKEKSGKSSSDLKDKEPQLKNEEKSKPQVKKEAKLASSDKGQTRKQNITRPEQVIPHVKPEKAEHQEKGHPSIKKDKPKPSSKGAPEVPDSGKKKIEKSEKESKVPTREENLQVYNVTKAEKPGKIPKDSKEAPASKKDKEDSKEAPTSKKDKEDSKDVPHSKKDKEVTDDVSSPKKQTRPISFFQCVYLNGYNGYGFQFPVTPVQQPGENPGKTNSPGQKQQEQ
uniprot
proteins
function
FUNCTION: Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength (PubMed:19843516). Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000269|PubMed:19383796, ECO:0000269|PubMed:19843516, ECO:0000269|PubMed:22768324}.
uniprot
proteins
mass_dalton
77844
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CaMK2. {ECO:0000250|UniProtKB:Q28820}.; PTM: N-glycosylated. {ECO:0000269|PubMed:19383796}.
uniprot
proteins
pubmed
11707337
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19383796
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19843516
uniprot
proteins
pubmed
22768324
uniprot
proteins
sequence_length
693
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:11707337}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q28820}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..68; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins