ANKRA2
entrez
57763
canonical
uniprot
Q9H9E1
canonical
ensembl
ENSG00000164331
resolver
ensp
ENSP00000296785
resolver
ensp
ENSP00000530832
resolver
ensp
ENSP00000750795
resolver
enst
ENST00000296785
resolver
enst
ENST00000860773
resolver
genesymbol
ANKRA2
resolver
genesymbol_syn
ANKRA
resolver
hgnc
HGNC:13208
resolver
uniprot_entry
ANRA2_HUMAN
resolver
amino_acid_sequence
MDTSTNLDIGAQLIVEECPSTYSLTGMPDIKIEHPLDPNSEEGSAQGVAMGMKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQNIKE
uniprot
proteins
function
FUNCTION: May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity). {ECO:0000250|UniProtKB:A2ARV4, ECO:0000269|PubMed:25752541}.
uniprot
proteins
mass_dalton
34272
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="K->R: No effect on interaction with CCDC8."; /evidence="ECO:0000269|PubMed:25752541"; MUTAGEN 188; /note="W->A: Loss of interaction with CCDC8. Decreased affinity for HDAC4."; /evidence="ECO:0000269|PubMed:22649097, ECO:0000269|PubMed:25752541"; MUTAGEN 254; /note="Y->A: Decreased affinity for HDAC4."; /evidence="ECO:0000269|PubMed:22649097
uniprot
proteins
pubmed
11095640
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20873783
uniprot
proteins
pubmed
22649097
uniprot
proteins
pubmed
25752541
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q99PE2}. Membrane {ECO:0000250|UniProtKB:Q99PE2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99PE2}.
uniprot
proteins