TIMM23
entrez
100287932
canonical
uniprot
O14925
canonical
ensembl
ENSG00000265354
resolver
ensp
ENSP00000464522
resolver
enst
ENST00000580018
resolver
genesymbol
TIMM23
resolver
genesymbol_syn
TIM23
resolver
hgnc
HGNC:17312
resolver
uniprot
Q53FF8
resolver
uniprot
Q5T1E6
resolver
uniprot
Q6P5S5
resolver
uniprot_entry
TIM23_HUMAN
resolver
uniprot_sec
Q53FF8
resolver
uniprot_sec
Q5T1E6
resolver
uniprot_sec
Q6P5S5
resolver
amino_acid_sequence
MEGGGGSGNKTTGGLAGFFGAGGAGYSHADLAGVPLTGMNPLSPYLNVDPRYLVQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKETQNMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGIARGGLTGLTLTSLYALYNNWEHMKGSLLQQSL
uniprot
proteins
function
FUNCTION: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (PubMed:10339406). Has a role in the activation of stress-induced mitophagy by protecting PINK1 from OMA1-mediated degradation and facilitating its accumulation at the outer mitochondrial membrane in response to depolarization (PubMed:37160114). {ECO:0000269|PubMed:37160114, ECO:0000305|PubMed:10339406}.
uniprot
proteins
mass_dalton
21943
uniprot
proteins
protein_family
Tim17/Tim22/Tim23 family
uniprot
proteins
pubmed
10339406
uniprot
proteins
pubmed
15044455
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23263864
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
25997101
uniprot
proteins
pubmed
37160114
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:25997101}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 73..93; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 125..145; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 181..197; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins