PQLC2
entrez
54896
canonical
uniprot
Q6ZP29
canonical
ensembl
ENSG00000040487
resolver
ensp
ENSP00000364295
resolver
ensp
ENSP00000364297
resolver
ensp
ENSP00000383395
resolver
ensp
ENSP00000572290
resolver
ensp
ENSP00000798830
resolver
genesymbol
PQLC2
resolver
genesymbol
SLC66A1
resolver
genesymbol_syn
PQLC2
resolver
hgnc
HGNC:26001
resolver
uniprot
A0A024RAA1
resolver
uniprot
B3KWQ5
resolver
uniprot
Q6ZMJ3
resolver
uniprot
Q6ZP27
resolver
uniprot
Q9NXC7
resolver
uniprot_entry
A0A024RAA1_HUMAN
resolver
uniprot_entry
LAAT1_HUMAN
resolver
uniprot_sec
B3KWQ5
resolver
uniprot_sec
Q6ZMJ3
resolver
uniprot_sec
Q6ZP27
resolver
uniprot_sec
Q9NXC7
resolver
amino_acid_sequence
MVWKKLGSRNFSSCPSGSIQWIWDVLGECAQDGWDEASVGLGLISILCFAASTFPQFIKAYKTGNMDQALSLWFLLGWIGGDSCNLIGSFLADQLPLQTYTAVYYVLADLVMLTLYFYYKFRTRPSLLSAPINSVLLFLMGMACATPLLSAAGPVAAPREAFRGRALLSVESGSKPFTRQEVIGFVIGSISSVLYLLSRLPQIRTNFLRKSTQGISYSLFALVMLGNTLYGLSVLLKNPEEGQSEGSYLLHHLPWLVGSLGVLLLDTIISIQFLVYRRSTAASELEPLLPS
uniprot
proteins
function
FUNCTION: Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. {ECO:0000269|PubMed:22822152, ECO:0000269|PubMed:23169667}.
uniprot
proteins
mass_dalton
31947
uniprot
proteins
mutagenesis
MUTAGEN 55; /note="P->L: Abolishes uptake of arginine and lysine."; /evidence="ECO:0000269|PubMed:22822152"; MUTAGEN 288..289; /note="Missing: Abolishes lysosomal localization."; /evidence="ECO:0000269|PubMed:22822152
uniprot
proteins
protein_family
Laat-1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
22822152
uniprot
proteins
pubmed
23169667
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:22822152}; Multi-pass membrane protein {ECO:0000269|PubMed:22822152}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 99..119; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 135..155; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 215..235; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins