Q8IZP1
uniprot
Q8IZP1
canonical
amino_acid_sequence
MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKKGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF
uniprot
proteins
function
FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. {ECO:0000269|PubMed:12359748}.
uniprot
proteins
mass_dalton
62187
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation. {ECO:0000269|PubMed:23578663}.; PTM: Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination. {ECO:0000269|PubMed:23578663}.
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12359748
uniprot
proteins
pubmed
12604796
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
21030649
uniprot
proteins
pubmed
23578663
uniprot
proteins
pubmed
8406013
uniprot
proteins
pubmed
8471161
uniprot
proteins
sequence_length
549
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23578663}; Lipid-anchor {ECO:0000269|PubMed:23578663}. Note=Associated with lipid rafts.
uniprot
proteins