Rasgrp2
entrez
361714
canonical
uniprot
P0C643
canonical
ensembl
ENSRNOG00000021098
resolver
ensp
ENSRNOP00000102158
resolver
enst
ENSRNOT00000162040
resolver
genesymbol
Rasgrp2
resolver
uniprot
A0ABK0LAG4
resolver
uniprot_entry
A0ABK0LAG4_RAT
resolver
uniprot_entry
GRP2_RAT
resolver
amino_acid_sequence
MASTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLASKLLHFYQQSRKDNSNSLQVKTCHLVRYWVSAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIESVPTYKWKRQVTQRNPVEQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTATQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPDTIKLWEGLTELVTATGNYSNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPGRTRLNGAKMRQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSVAKPKLDQALVAEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMISYFLRSSSVLGGRMGFVHNLQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSPTHTHHRAFSFSLPRPGRRSSRPPEIREEEVQTVEDGVFDIHL
uniprot
proteins
function
FUNCTION: Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000250|UniProtKB:Q7LDG7, ECO:0000269|PubMed:11292831}.
uniprot
proteins
mass_dalton
69291
uniprot
proteins
protein_family
RASGRP family
uniprot
proteins
pubmed
11292831
uniprot
proteins
pubmed
11503142
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9789079
uniprot
proteins
sequence_length
608
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000269|PubMed:11503142, ECO:0000269|PubMed:9789079}. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Found both in the cytosol and associated with membranes (By similarity). Enriched at juxtamembrane areas and membrane ruffles (By similarity). Localizes to the cell bodies and axons of striatal neurons. {ECO:0000250}.
uniprot
proteins