Hdac2
entrez
15182
canonical
uniprot
P70288
canonical
ensembl
ENSMUSG00000019777
resolver
ensp
ENSMUSP00000019911
resolver
enst
ENSMUST00000019911
resolver
genesymbol
Hdac2
resolver
genesymbol_syn
Yy1bp
resolver
uniprot
A0A0R4J008
resolver
uniprot
B2RRP3
resolver
uniprot
Q3TMT1
resolver
uniprot_entry
A0A0R4J008_MOUSE
resolver
uniprot_entry
HDAC2_MOUSE
resolver
uniprot_entry
Q3TMT1_MOUSE
resolver
uniprot_sec
B2RRP3
resolver
activity_regulation
ACTIVITY REGULATION: Inositol tetraphosphate (1D-myo-inositol 1,4,5,6-tetrakisphosphate) may act as an intermolecular glue between HDAC2 and N-Cor repressor complex components. {ECO:0000250|UniProtKB:O15379}.
uniprot
proteins
amino_acid_sequence
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVAKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDPKGAKSEQLSNP
uniprot
proteins
ec_number
3.5.1.-
uniprot
proteins
ec_number
3.5.1.98
uniprot
proteins
function
FUNCTION: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:18754010). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:18754010). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:18754010). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (By similarity). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:17707228). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (By similarity). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (By similarity). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (PubMed:15226430). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:20071335). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:30279482). {ECO:0000250|UniProtKB:Q92769, ECO:0000269|PubMed:15226430, ECO:0000269|PubMed:17707228, ECO:0000269|PubMed:18754010, ECO:0000269|PubMed:20071335, ECO:0000269|PubMed:30279482}.
uniprot
proteins
mass_dalton
55302
uniprot
proteins
mutagenesis
MUTAGEN 152; /note="C->A: Does not affect S-nitrosylation."; /evidence="ECO:0000269|PubMed:18754010"; MUTAGEN 262; /note="C->A: Impairs S-nitrosylation. Abolishes S-nitrosylation; when associated with A-274."; /evidence="ECO:0000269|PubMed:18754010"; MUTAGEN 274; /note="C->A: Impairs S-nitrosylation. Abolishes S-nitrosylation; when associated with A-262."; /evidence="ECO:0000269|PubMed:18754010
uniprot
proteins
post_translational_modification
PTM: S-nitrosylated by GAPDH. In neurons, S-nitrosylation at Cys-262 and Cys-274 does not affect enzyme activity, but induces HDAC2 release from chromatin. This in turn increases acetylation of histones surrounding neurotrophin-dependent gene promoters and promotes their transcription. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching. {ECO:0000269|PubMed:18754010, ECO:0000269|PubMed:20519513, ECO:0000269|PubMed:20972425}.
uniprot
proteins
protein_family
HD type 1 subfamily
uniprot
proteins
protein_family
Histone deacetylase family
uniprot
proteins
pubmed
10984530
uniprot
proteins
pubmed
11533236
uniprot
proteins
pubmed
11788710
uniprot
proteins
pubmed
12398767
uniprot
proteins
pubmed
15226430
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16107708
uniprot
proteins
pubmed
16537907
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17666527
uniprot
proteins
pubmed
17707228
uniprot
proteins
pubmed
18754010
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
20071335
uniprot
proteins
pubmed
20519513
uniprot
proteins
pubmed
20972425
uniprot
proteins
pubmed
21177534
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22391310
uniprot
proteins
pubmed
24227653
uniprot
proteins
pubmed
27806305
uniprot
proteins
pubmed
28314777
uniprot
proteins
pubmed
30279482
uniprot
proteins
pubmed
34075040
uniprot
proteins
pubmed
34180153
uniprot
proteins
pubmed
35341968
uniprot
proteins
pubmed
8917507
uniprot
proteins
pubmed
9702189
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92769}. Cytoplasm {ECO:0000250|UniProtKB:Q92769}.
uniprot
proteins