Pde10a
entrez
63885
canonical
uniprot
Q9QYJ6
canonical
ensembl
ENSRNOG00000011310
resolver
ensembl
ENSRNOG00055028570
resolver
ensembl
ENSRNOG00060010248
resolver
ensembl
ENSRNOG00065029728
resolver
ensp
ENSRNOP00000060834
resolver
ensp
ENSRNOP00000086612
resolver
ensp
ENSRNOP00000086886
resolver
ensp
ENSRNOP00000091632
resolver
ensp
ENSRNOP00000104055
resolver
ensp
ENSRNOP00000107322
resolver
ensp
ENSRNOP00000108193
resolver
enst
ENSRNOT00000067142
resolver
enst
ENSRNOT00000102087
resolver
enst
ENSRNOT00000172789
resolver
genesymbol
Pde10a
resolver
uniprot
A0A8I6A446
resolver
uniprot
A0ABK0M1D1
resolver
uniprot
F1LX13
resolver
uniprot
Q6S9E6
resolver
uniprot
Q6S9E7
resolver
uniprot
Q6S9E8
resolver
uniprot
Q6S9E9
resolver
uniprot
Q9QYJ5
resolver
uniprot_entry
A0A8I6A446_RAT
resolver
uniprot_entry
A0ABK0M1D1_RAT
resolver
uniprot_entry
F1LX13_RAT
resolver
uniprot_entry
PDE10_RAT
resolver
uniprot_sec
Q6S9E6
resolver
uniprot_sec
Q6S9E7
resolver
uniprot_sec
Q6S9E8
resolver
uniprot_sec
Q6S9E9
resolver
uniprot_sec
Q9QYJ5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by dipyridamole and moderately by IBMX, zaprinast and rolipram. {ECO:0000269|PubMed:10583409}.
uniprot
proteins
amino_acid_sequence
MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKAEDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYFLGECNNSLCVFTPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMHFNLPARICRDIELFHFDIGPFENMWPGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPATSKSTSEKPTRKVDD
uniprot
proteins
ec_number
3.1.4.17
uniprot
proteins
function
FUNCTION: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. {ECO:0000269|PubMed:10583409}.
uniprot
proteins
mass_dalton
90161
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. {ECO:0000269|PubMed:10583409, ECO:0000269|PubMed:14752115}.; PATHWAY: Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1. {ECO:0000269|PubMed:10583409, ECO:0000269|PubMed:14752115}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
pubmed
10583409
uniprot
proteins
pubmed
14752115
uniprot
proteins
pubmed
17228859
uniprot
proteins
sequence_length
794
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10583409}.
uniprot
proteins