ASCC2
entrez
84164
canonical
uniprot
Q9H1I8
canonical
ensembl
ENSG00000100325
resolver
ensp
ENSP00000305502
resolver
ensp
ENSP00000380877
resolver
ensp
ENSP00000437570
resolver
ensp
ENSP00000535622
resolver
ensp
ENSP00000535623
resolver
ensp
ENSP00000535625
resolver
ensp
ENSP00000535626
resolver
ensp
ENSP00000535627
resolver
ensp
ENSP00000535630
resolver
ensp
ENSP00000535631
resolver
ensp
ENSP00000535632
resolver
ensp
ENSP00000535634
resolver
ensp
ENSP00000535640
resolver
ensp
ENSP00000535641
resolver
ensp
ENSP00000535646
resolver
ensp
ENSP00000535651
resolver
ensp
ENSP00000593338
resolver
ensp
ENSP00000593346
resolver
ensp
ENSP00000593347
resolver
ensp
ENSP00000630699
resolver
ensp
ENSP00000630708
resolver
genesymbol
ASCC2
resolver
genesymbol_syn
ASC1P100
resolver
genesymbol_syn
RQT3
resolver
hgnc
HGNC:24103
resolver
uniprot
B7Z8E0
resolver
uniprot
F5H6J9
resolver
uniprot
Q4TT54
resolver
uniprot
Q8TAZ0
resolver
uniprot
Q9H711
resolver
uniprot
Q9H9D6
resolver
uniprot_entry
ASCC2_HUMAN
resolver
uniprot_sec
B7Z8E0
resolver
uniprot_sec
F5H6J9
resolver
uniprot_sec
Q4TT54
resolver
uniprot_sec
Q8TAZ0
resolver
uniprot_sec
Q9H711
resolver
uniprot_sec
Q9H9D6
resolver
amino_acid_sequence
MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERATFVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLHRSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMIGNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLLELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLEDSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQEKRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVIEEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLPDLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVFQNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQPGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEEDDDDEEDDADEEAPKPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQSRETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS
uniprot
proteins
function
FUNCTION: Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes (PubMed:29144457, PubMed:32099016, PubMed:32579943, PubMed:36302773). Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29144457). Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:36302773). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}.
uniprot
proteins
mass_dalton
86360
uniprot
proteins
mutagenesis
MUTAGEN 478..479; /note="LL->AA: Loss of ubiquitin binding."; /evidence="ECO:0000269|PubMed:29144457"; MUTAGEN 479..491; /note="LPDLGEGFILACL->AADLGEGFALACA: Decreases ubiquitin binding."; /evidence="ECO:0000269|PubMed:32099016"; MUTAGEN 506; /note="L->A: Loss of ubiquitin binding."; /evidence="ECO:0000269|PubMed:29144457
uniprot
proteins
protein_family
ASCC2 family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12077347
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22055184
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26924529
uniprot
proteins
pubmed
29144457
uniprot
proteins
pubmed
29997253
uniprot
proteins
pubmed
31799605
uniprot
proteins
pubmed
32099016
uniprot
proteins
pubmed
32579943
uniprot
proteins
pubmed
36302773
uniprot
proteins
sequence_length
757
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:26924529, ECO:0000269|PubMed:29144457}. Nucleus speckle {ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:29997253}. Note=Colocalizes with the spliceosomal components PRPF8 and SNRNP200/BRR2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. Colocalizes with RNF113A and 'Lys-63'-linked polyubiquitinated proteins, ALKBH3 and ASCC3 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. {ECO:0000269|PubMed:29144457}.
uniprot
proteins