Npy2r
entrez
18167
canonical
uniprot
P97295
canonical
ensembl
ENSMUSG00000028004
resolver
ensp
ENSMUSP00000029633
resolver
ensp
ENSMUSP00000096595
resolver
ensp
ENSMUSP00000138282
resolver
ensp
ENSMUSP00000138559
resolver
enst
ENSMUST00000029633
resolver
enst
ENSMUST00000098997
resolver
enst
ENSMUST00000182181
resolver
enst
ENSMUST00000182831
resolver
genesymbol
Npy2r
resolver
uniprot
F7C6W7
resolver
uniprot
Q3SWR9
resolver
uniprot
Q8BWV1
resolver
uniprot
S4R2A0
resolver
uniprot_entry
NPY2R_MOUSE
resolver
uniprot_entry
Q3SWR9_MOUSE
resolver
uniprot_entry
S4R2A0_MOUSE
resolver
uniprot_sec
F7C6W7
resolver
uniprot_sec
Q8BWV1
resolver
amino_acid_sequence
MGPVGAEADENQTVEVKVEPYGPGHTTPRGELPPDPEPELIDSTKLVEVQVILILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLRNHVSPGAASDHYHQRRHKMTKMLVCVVVVFAVSWLPLHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSMTFKAKKNLEVKKNNGPTDSFSEATNV
uniprot
proteins
function
FUNCTION: Receptor for neuropeptide Y (NPY) and peptide YY (PYY) (PubMed:8914576). Can also bind with lower affinity pancreatic polypeptide (PP/PPY) and [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form (By similarity). NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels (PubMed:8914576). Involved in the regulation of colonic antisecretory tone, and colonic contractility (PubMed:21457230). As receptor for peptide PYY(3-36) in the arcuate nucleus of the hypothalamus, it is involved in the down-regulation of appetite and food intake (PubMed:12167864, PubMed:16280589). {ECO:0000250|UniProtKB:P49146, ECO:0000269|PubMed:21457230, ECO:0000269|PubMed:8914576}.
uniprot
proteins
mass_dalton
42628
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10436066
uniprot
proteins
pubmed
12167864
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16280589
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21457230
uniprot
proteins
pubmed
8914576
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P49146}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P49146}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..73; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P49146"; TRANSMEM 87..113; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P49146"; TRANSMEM 120..146; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P49146"; TRANSMEM 164..186; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P49146"; TRANSMEM 214..240; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P49146"; TRANSMEM 268..292; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P49146"; TRANSMEM 302..326; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P49146
uniprot
proteins