Lim2
entrez
233187
canonical
uniprot
P56563
canonical
ensembl
ENSMUSG00000118560
resolver
ensp
ENSMUSP00000004732
resolver
enst
ENSMUST00000004732
resolver
genesymbol
Lim2
resolver
uniprot
Q0VEF3
resolver
uniprot
Q3TNV8
resolver
uniprot
Q99PA6
resolver
uniprot_entry
LMIP_MOUSE
resolver
uniprot_sec
Q0VEF3
resolver
uniprot_sec
Q3TNV8
resolver
uniprot_sec
Q99PA6
resolver
amino_acid_sequence
MYSFMGGGLFCAWVGTILLVVATATDHWMQYRLSGSFAHQGLWRYCLGNKCFLQTESIAYWNATRAFMILSALCATSGIIMGVLAFAQQSTFTRLSRPFSAGIMFFASTLFVLLALAIYTGVTVSFLGRRFGDWRFSWSYILGWVALLMTFFAGIFYMCAYRMHECRRLATPR
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Lim2 are the cause of the cataractous mouse mutant with total opacity of lens 3 (To3). Mice heterozygous or homozygous for the To3 mutation have total opacity of the lens with a dense cataract. In addition, the To3/To3 homozygotes exhibit microphthalmia, abnormally small eyes. {ECO:0000269|PubMed:9238094}.
uniprot
proteins
function
FUNCTION: Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.
uniprot
proteins
mass_dalton
19621
uniprot
proteins
protein_family
PMP-22/EMP/MP20 family
uniprot
proteins
pubmed
11290961
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9238094
uniprot
proteins
sequence_length
173
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 67..87; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 99..119; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins