Ccnh
entrez
66671
canonical
uniprot
Q61458
canonical
ensembl
ENSMUSG00000021548
resolver
ensp
ENSMUSP00000022030
resolver
ensp
ENSMUSP00000129349
resolver
ensp
ENSMUSP00000192889
resolver
ensp
ENSMUSP00000192901
resolver
enst
ENSMUST00000022030
resolver
enst
ENSMUST00000163600
resolver
genesymbol
Ccnh
resolver
uniprot
E9PWD3
resolver
uniprot
Q9CVJ0
resolver
uniprot
Q9JHV7
resolver
uniprot_entry
CCNH_MOUSE
resolver
uniprot_entry
E9PWD3_MOUSE
resolver
uniprot_sec
Q9CVJ0
resolver
uniprot_sec
Q9JHV7
resolver
amino_acid_sequence
MYHSSSQKRHWTFASEEQLARLRADANRKFKCKAVANGKVLPNDPVFLEPHEELTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQERALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDIKTRYPMLENPEILRKTADDFLSRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSDEVAVLKQKLERCHSSDLALNAVTKKRKGYEDDDYVSKKPKQEEEEWTDDDLVDSL
uniprot
proteins
function
FUNCTION: Component of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalyzing the activating threonine phosphorylation of CDKs. Binds and activates cyclin-dependent protein kinase CDK7, the catalytic subunit of CAK (By similarity). CAK activates major mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, and plays a key role in regulating cell cycle progression (By similarity). CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts (By similarity). Involved in cell cycle control and in RNA transcription by RNA polymerase II (By similarity). Its expression and activity are constant throughout the cell cycle. {ECO:0000250|UniProtKB:P51946}.
uniprot
proteins
mass_dalton
37506
uniprot
proteins
protein_family
Cyclin C subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
11319144
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins