P50538
uniprot
P50538
canonical
amino_acid_sequence
MATAVGMNIQLLLEAADYLERREREAEHGYASMLPYSKDRDAFKRRNKPKKNSTSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRRLEKLGAERTRMDSVGSVVSSERSDSDREELDVDVDVDVDVDVEGTDYLNGDLGWSSSVSDSDERGSMQSLGSDEGYSSATVKRAKLQDGHKAGLGL
uniprot
proteins
function
FUNCTION: Component of a transcriptional repressor complex together with MAX (By similarity). In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (By similarity). Antagonizes MYC transcriptional activity by competing with MYC for MAX binding (By similarity). Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (By similarity). {ECO:0000250|UniProtKB:Q05195}.
uniprot
proteins
mass_dalton
25562
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by BIRC2/c-IAP1, leading to its subsequent degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
pubmed
10597267
uniprot
proteins
pubmed
7667316
uniprot
proteins
pubmed
7896882
uniprot
proteins
pubmed
8521822
uniprot
proteins
pubmed
8617250
uniprot
proteins
pubmed
9519870
uniprot
proteins
sequence_length
227
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q05195}.
uniprot
proteins