Il24
entrez
170819
canonical
uniprot
Q9JI24
canonical
ensembl
ENSRNOG00000004470
resolver
ensembl
ENSRNOG00065020565
resolver
ensp
ENSRNOP00000006106
resolver
ensp
ENSRNOP00065027971
resolver
enst
ENSRNOT00000006106
resolver
enst
ENSRNOT00065034829
resolver
genesymbol
Il24
resolver
genesymbol_syn
Mob5
resolver
uniprot_entry
IL24_RAT
resolver
amino_acid_sequence
MQTSLRQQILPGLSLILLVLNQVPELQGQEFRFGPCQVTGVVLPELWEAFWTVKNTVKTQDELTSVRLLKPQVLQNVSDAESCYLAHSLLKFYLNTVFKNYHSKIVKFKVLKSFSTLANNFLVIMSKLQPSKDNAMLPISDSARRRFLLYHRTFKQLDIEVALAKAFGEVDILLAWMQNFYQL
uniprot
proteins
function
FUNCTION: Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (By similarity). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity). {ECO:0000250|UniProtKB:Q13007, ECO:0000250|UniProtKB:Q925S4}.
uniprot
proteins
mass_dalton
21096
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q13007}.; PTM: Ubiquitination at Lys-99 promotes proteasomal degradation. {ECO:0000250|UniProtKB:Q13007}.
uniprot
proteins
protein_family
IL-10 family
uniprot
proteins
pubmed
10825166
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q13007}.
uniprot
proteins