AK6
entrez
102157402
canonical
uniprot
Q9Y3D8
canonical
ensembl
ENSG00000085231
resolver
ensembl
ENSG00000279247
resolver
ensp
ENSP00000370197
resolver
ensp
ENSP00000370201
resolver
genesymbol
AK6
resolver
genesymbol_syn
CINAP
resolver
hgnc
HGNC:49151
resolver
uniprot
A0AAU7BBC0
resolver
uniprot
A8MSZ6
resolver
uniprot
Q5F2S9
resolver
uniprot_entry
A0AAU7BBC0_HUMAN
resolver
uniprot_entry
KAD6_HUMAN
resolver
uniprot_sec
A8MSZ6
resolver
uniprot_sec
Q5F2S9
resolver
amino_acid_sequence
MLLPNILLTGTPGVGKTTLGKELASKSGLKYINVGDLAREEQLYDGYDEEYDCPILDEDRVVDELDNQMREGGVIVDYHGCDFFPERWFHIVFVLRTDTNVLYERLETRGYNEKKLTDNIQCEIFQVLYEEATASYKEEIVHQLPSNKPEELENNVDQILKWIEQWIKDHNS
uniprot
proteins
ec_number
2.7.4.3
uniprot
proteins
function
FUNCTION: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Also has ATPase activity (PubMed:15630091). Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation (PubMed:27477389). While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit (By similarity). Its NMP activity may have a role in nuclear energy homeostasis. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May be involved in regulation of Cajal body (CB) formation (PubMed:15630091). {ECO:0000255|HAMAP-Rule:MF_03173, ECO:0000269|PubMed:15630091, ECO:0000269|PubMed:27477389}.
uniprot
proteins
mass_dalton
20061
uniprot
proteins
mutagenesis
MUTAGEN 79; /note="H->G: Induces homodimerization. Reduces adenylate kinase activity by 72% and ATPase activity by 76%. Significantly changes Cajal body organization in the nucleus, resulting in enhanced apoptosis and reduced proliferation."; /evidence="ECO:0000269|PubMed:22038794
uniprot
proteins
protein_family
AK6 subfamily
uniprot
proteins
protein_family
Adenylate kinase family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
15213396
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15630091
uniprot
proteins
pubmed
16079131
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22038794
uniprot
proteins
pubmed
27477389
uniprot
proteins
sequence_length
172
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03173}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03173}. Nucleus, Cajal body {ECO:0000255|HAMAP-Rule:MF_03173}. Note=Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells. {ECO:0000255|HAMAP-Rule:MF_03173}.
uniprot
proteins