Slc22a12
entrez
365398
canonical
uniprot
Q3ZAV1
canonical
ensembl
ENSRNOG00000021108
resolver
ensembl
ENSRNOG00055022705
resolver
ensembl
ENSRNOG00060032833
resolver
ensembl
ENSRNOG00065029702
resolver
ensp
ENSRNOP00000075925
resolver
ensp
ENSRNOP00055031635
resolver
ensp
ENSRNOP00060046980
resolver
ensp
ENSRNOP00065042239
resolver
enst
ENSRNOT00000092270
resolver
enst
ENSRNOT00055038962
resolver
enst
ENSRNOT00060056897
resolver
enst
ENSRNOT00065051300
resolver
genesymbol
Slc22a12
resolver
genesymbol_syn
Urat1
resolver
uniprot_entry
S22AC_RAT
resolver
amino_acid_sequence
MAFPELLDRVGGRGRFQLLQAVALVTPILWVTTQNMLENFSAAVPHHRCWVPLLDNSTSQASIPGDFGRDVLLAVSIPPGPDQRPHQCLRFRQPQWQLIESNTTATNWSDADTEPCEDGWVYDHSTFRSTIVTTWDLVCDSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWSYLLVSVSGTIAALMPTFPLYCLFRFLVASAVAGVMMNTASLLMEWTSAQAGPLMMTLNALGFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWWLPESARWLITVGRLDQSLRELQRVAAVNRRKAEADTLTVEVLRSAMQEEPNGNQAGARLGTLLHTPGLRLRTFISMLCWFAFGFTFYGLALDLQALGSNIFLLQALIGIVDLPVKMGSLLLLSRLGRRLCQASSLVLPGLCILANILVPREMGILRSSLAVLGLGSLGAAFTCVTIFSSELFPTVIRMTAVGLGQVAARGGAMLGPLVRLLGVYGSWLPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQDIQKQSVKKVTHDIAGGSVLKSARL
uniprot
proteins
function
FUNCTION: Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:21074513). Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:21074513). Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) (PubMed:21074513). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (By similarity). Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. Orotate transport is Cl(-)-dependent (By similarity). {ECO:0000250|UniProtKB:Q96S37, ECO:0000269|PubMed:21074513}.
uniprot
proteins
mass_dalton
60245
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q8CFZ5}.
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21074513
uniprot
proteins
sequence_length
553
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:21074513}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 182..202; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 351..371; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 378..398; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 435..455; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 466..486; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 495..515; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins