Pphln1
entrez
223828
canonical
uniprot
Q8K2H1
canonical
ensembl
ENSMUSG00000036167
resolver
ensp
ENSMUSP00000042762
resolver
ensp
ENSMUSP00000068165
resolver
ensp
ENSMUSP00000104879
resolver
ensp
ENSMUSP00000131121
resolver
ensp
ENSMUSP00000154876
resolver
ensp
ENSMUSP00000301571
resolver
ensp
ENSMUSP00000301572
resolver
ensp
ENSMUSP00000301575
resolver
ensp
ENSMUSP00000301576
resolver
ensp
ENSMUSP00000301586
resolver
ensp
ENSMUSP00000301588
resolver
ensp
ENSMUSP00000301594
resolver
ensp
ENSMUSP00000301596
resolver
ensp
ENSMUSP00000301597
resolver
enst
ENSMUST00000049122
resolver
enst
ENSMUST00000068457
resolver
enst
ENSMUST00000109256
resolver
enst
ENSMUST00000165935
resolver
enst
ENSMUST00000229071
resolver
genesymbol
Pphln1
resolver
uniprot
F6ZEH4
resolver
uniprot
G3UWD4
resolver
uniprot
G3X959
resolver
uniprot
Q3TYM7
resolver
uniprot
Q3UBL8
resolver
uniprot
Q8BUZ6
resolver
uniprot_entry
F6ZEH4_MOUSE
resolver
uniprot_entry
G3UWD4_MOUSE
resolver
uniprot_entry
G3X959_MOUSE
resolver
uniprot_entry
PPHLN_MOUSE
resolver
uniprot_entry
Q3TYM7_MOUSE
resolver
uniprot_entry
Q3UBL8_MOUSE
resolver
uniprot_sec
Q8BUZ6
resolver
amino_acid_sequence
MWSEGRYDYDRLPRERVPPRSHPSDGYHRVVNVVPKRPPLLDKRPPLLDKRPPLLARPDEGGYSRYYSHVDCRVCDEGRSFSHDRRSGPSHSGDESGYRWLRDDHSTSRQPDYRDMRDGFRRKSFYSSHYSRDRSPHKRDAPFFRESPVGRKDSPHSRSGSSVSSRSYSPERSRTHSFHQSQHRKSSRVGASYKRQNEAIRGRGKERSIQSVKTSRDASPSSSSAVASSKALDKPSRLTEKELAEAESKWANETLEKSDESNLAEMNEFEAGSTAPLFIDQTEEPESNTVDGTELYEDSQLSNRSKAIASKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSVQFALRQNLHEIGERCVEELKRFITEYDNSARDFGDPF
uniprot
proteins
function
FUNCTION: RNA-binding component of the HUSH complex, a multiprotein complex that mediates epigenetic repression of mobile genetic elements, such as retroviruses and transposable elements (By similarity). The HUSH complex mainly represses LINE-1 (L1) retrotransposons that are still capable of transposition (By similarity). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2, a chromatin remodeler that compacts chromatin (By similarity). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (By similarity). Within the HUSH complex, PPHLN1 acts as a mRNA-binding component, which specifically binds nascent transcripts of mobile genetic elements, enabling HUSH-dependent silencing of transcripts (By similarity). Contributes to the maintenance of the HUSH complex at chromatin (By similarity). As part of the HUSH2 complex, promotes epigenetic repression of interferon-stimulated genes (By similarity). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (By similarity). {ECO:0000250|UniProtKB:Q8NEY8}.
uniprot
proteins
mass_dalton
43835
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19621438
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8NEY8}. Cytoplasm {ECO:0000250|UniProtKB:Q8NEY8}. Chromosome {ECO:0000250|UniProtKB:Q8NEY8}. Note=In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions. Localizes to chromatin. {ECO:0000250|UniProtKB:Q8NEY8}.
uniprot
proteins