Arpc4
entrez
68089
canonical
uniprot
P59999
canonical
ensembl
ENSMUSG00000079426
resolver
ensp
ENSMUSP00000114839
resolver
ensp
ENSMUSP00000131690
resolver
ensp
ENSMUSP00000144751
resolver
ensp
ENSMUSP00000145344
resolver
enst
ENSMUST00000156898
resolver
enst
ENSMUST00000171058
resolver
enst
ENSMUST00000203578
resolver
enst
ENSMUST00000204802
resolver
genesymbol
Arpc4
resolver
genesymbol_syn
Arc20
resolver
uniprot
A0A0N4SW27
resolver
uniprot
E9PWA7
resolver
uniprot
O15509
resolver
uniprot
Q3TX55
resolver
uniprot
Q3UWV4
resolver
uniprot_entry
A0A0N4SW27_MOUSE
resolver
uniprot_entry
ARPC4_MOUSE
resolver
uniprot_entry
E9PWA7_MOUSE
resolver
uniprot_entry
Q3TX55_MOUSE
resolver
uniprot_sec
O15509
resolver
uniprot_sec
Q3UWV4
resolver
amino_acid_sequence
MTATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEVRSSKELLLQPVTISRNEKEKVLIEGSINSVRVSIAVKQADEIEKILCHKFMRFMMMRAENFFILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVAEEFLKNF
uniprot
proteins
function
FUNCTION: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). {ECO:0000250|UniProtKB:P59998}.
uniprot
proteins
mass_dalton
19667
uniprot
proteins
protein_family
ARPC4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P59998}. Cell projection {ECO:0000250|UniProtKB:P59998}. Nucleus {ECO:0000250|UniProtKB:P59998}.
uniprot
proteins