NPY2R
entrez
4887
canonical
uniprot
P49146
canonical
ensembl
ENSG00000185149
resolver
ensp
ENSP00000332591
resolver
ensp
ENSP00000426366
resolver
enst
ENST00000329476
resolver
enst
ENST00000506608
resolver
genesymbol
NPY2R
resolver
hgnc
HGNC:7957
resolver
uniprot
Q13281
resolver
uniprot
Q13457
resolver
uniprot
Q4W5G7
resolver
uniprot
Q6AZZ6
resolver
uniprot
Q9UE67
resolver
uniprot_entry
NPY2R_HUMAN
resolver
uniprot_sec
Q13281
resolver
uniprot_sec
Q13457
resolver
uniprot_sec
Q4W5G7
resolver
uniprot_sec
Q6AZZ6
resolver
uniprot_sec
Q9UE67
resolver
amino_acid_sequence
MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
uniprot
proteins
function
FUNCTION: Receptor for neuropeptide Y (NPY) and peptide YY (PYY) (PubMed:7592910, PubMed:7559383, PubMed:35507650, PubMed:36525977, PubMed:38882210). Can also bind with lower affinity pancreatic polypeptide (PP/PPY) and [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form. NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production (PubMed:7592910, PubMed:7559383, PubMed:35507650, PubMed:38882210). Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels (PubMed:7559383, PubMed:7592910). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity). As receptor for peptide PYY(3-36) in the arcuate nucleus of the hypothalamus, it is involved in the down-regulation of appetite and food intake (By similarity). {ECO:0000250|UniProtKB:P97295, ECO:0000269|PubMed:35507650, ECO:0000269|PubMed:36525977, ECO:0000269|PubMed:38882210, ECO:0000269|PubMed:7559383, ECO:0000269|PubMed:7592910}.
uniprot
proteins
mass_dalton
42731
uniprot
proteins
mutagenesis
MUTAGEN 103; /note="C->A: Decreased neuropeptide Y receptor activity."; /evidence="ECO:0000269|PubMed:38882210"; MUTAGEN 107; /note="T->A: Decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650, ECO:0000269|PubMed:38882210"; MUTAGEN 130; /note="Q->A: Decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650, ECO:0000269|PubMed:38882210"; MUTAGEN 134; /note="V->A,W: Decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 138; /note="T->I: Has no effect on NPY- or PYY-induced interaction with GNAI1. Has no effect on NPY- or PYY-induced interaction with ARRB2."; /evidence="ECO:0000269|PubMed:36525977"; MUTAGEN 155; /note="H->P: Has no effect on NPY- or PYY-induced interaction with GNAI1. Increased NPY- or PYY-induced interaction with ARRB2."; /evidence="ECO:0000269|PubMed:36525977"; MUTAGEN 194; /note="I->A: No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 195; /note="I->A: No effect on neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 200; /note="I->A: Decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 202; /note="A->W: Decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 205; /note="E->A: Decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 210; /note="E->A: No effect on neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 211; /note="E->A: No effect on neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 227; /note="L->A: No effect on neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 266; /note="T->I: Has no effect on NPY- or PYY-induced interaction with GNAI1. Has no effect on NPY- or PYY-induced interaction with ARRB2."; /evidence="ECO:0000269|PubMed:36525977"; MUTAGEN 292; /note="D->A: Severely decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650, ECO:0000269|PubMed:38882210"; MUTAGEN 299; /note="D->A: No effect on neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 311; /note="H->A: Decreased NPY-induced signaling. Decreased localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
33531491
uniprot
proteins
pubmed
35507650
uniprot
proteins
pubmed
36525977
uniprot
proteins
pubmed
38882210
uniprot
proteins
pubmed
7499438
uniprot
proteins
pubmed
7559383
uniprot
proteins
pubmed
7592910
uniprot
proteins
pubmed
8632753
uniprot
proteins
pubmed
8643460
uniprot
proteins
pubmed
8975716
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:35507650}; Multi-pass membrane protein {ECO:0000269|PubMed:35507650}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..73; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:35507650, ECO:0007744|PDB:7X9B"; TRANSMEM 87..113; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:35507650, ECO:0007744|PDB:7X9B"; TRANSMEM 120..146; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:35507650, ECO:0007744|PDB:7X9B"; TRANSMEM 164..186; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:35507650, ECO:0007744|PDB:7X9B"; TRANSMEM 214..240; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:35507650, ECO:0007744|PDB:7X9B"; TRANSMEM 268..292; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:35507650, ECO:0007744|PDB:7X9B"; TRANSMEM 302..326; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:35507650, ECO:0007744|PDB:7X9B
uniprot
proteins