Trim24
entrez
21848
canonical
uniprot
Q64127
canonical
ensembl
ENSMUSG00000029833
resolver
ensp
ENSMUSP00000031859
resolver
ensp
ENSMUSP00000113063
resolver
ensp
ENSMUSP00000114001
resolver
enst
ENSMUST00000120238
resolver
genesymbol
Trim24
resolver
genesymbol_syn
Tif1
resolver
genesymbol_syn
Tif1a
resolver
uniprot
E9Q1U8
resolver
uniprot
Q3V0H4
resolver
uniprot
Q64126
resolver
uniprot_entry
E9Q1U8_MOUSE
resolver
uniprot_entry
Q3V0H4_MOUSE
resolver
uniprot_entry
TIF1A_MOUSE
resolver
uniprot_sec
Q64126
resolver
amino_acid_sequence
MEVAVEKAAAAAAPAGGPAAAAPSGENEAESRQGPDSESGGEASRLNLLDTCAVCHQNIQSRVPKLLPCLHSFCQRCLPAPQRYLMLTAPALGSAETPPPAPAPAPAPGSPAGGPSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKYTGNQIQNRIIEINQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNTTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQSSQPPGGLPSNQLSKFPTQISLAQLRLQHIQQQVMAQRQQVQRRPAPVGLPNPRMQGPIQQPSISHQHPPPRLINFQNHSPKPNGPVLPPYPQQLRYSPSQNVPRQTTIKPNPLQMAFLAQQAIKQWQISSVQAPPTTASSSSSTPSSPTITSAAGYDGKAFSSPMIDLSAPVGGSYNLPSLPDIDCSSTIMLDNIARKDTGVDHAQPRPPSNRTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNTNYPRSILTSLLLNSSQSSASEETVLRSDAPDSTGDQPGLHQENSSNGKSEWSDASQKSPVHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHLTCHVPTLTNFPSGEWICTFCRDLSKPEVDYDCDVPSHHSEKRKSEGLTKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYCMYTKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLESYFEELLKNLYPEKRFPKVEFRHEAEDCKFSDDSDDDFVQPRKKRLKSTEDRQLLK
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving TRIM24 produces a TRIM24-BRAF (T18) oncogene originally isolated from a furfural-induced hepatoma.
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (By similarity). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, such as RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. Required for normal transition from proliferating neonatal hepatocytes to quiescent adult hepatocytes. {ECO:0000250, ECO:0000269|PubMed:10610177, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:16880268, ECO:0000269|PubMed:18026104, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:19909775, ECO:0000269|PubMed:7744009}.; FUNCTION: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (By similarity). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway. Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (By similarity). {ECO:0000250|UniProtKB:O15164, ECO:0000269|PubMed:10610177, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:16880268, ECO:0000269|PubMed:18026104, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:19909775, ECO:0000269|PubMed:7744009}.
uniprot
proteins
mass_dalton
116657
uniprot
proteins
mutagenesis
MUTAGEN 724; /note="K->R: Loss of sumoylation; when associated with R-742."; /evidence="ECO:0000269|PubMed:11313457"; MUTAGEN 742; /note="K->R: Loss of sumoylation; when associated with R-724."; /evidence="ECO:0000269|PubMed:11313457
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000269|PubMed:11313457}.; PTM: Phosphorylated at Ser-768 by ATM kinase induces ubiquitination and degradation during DNA damage. {ECO:0000250|UniProtKB:O15164}.; PTM: Undergoes ubiquitination-mediated degradation in response to DNA damage. {ECO:0000250|UniProtKB:O15164}.
uniprot
proteins
pubmed
10610177
uniprot
proteins
pubmed
11313457
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16322096
uniprot
proteins
pubmed
16880268
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17412818
uniprot
proteins
pubmed
18026104
uniprot
proteins
pubmed
18287084
uniprot
proteins
pubmed
19556538
uniprot
proteins
pubmed
19909775
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
7744009
uniprot
proteins
pubmed
8978696
uniprot
proteins
sequence_length
1051
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10610177, ECO:0000269|PubMed:11313457, ECO:0000269|PubMed:16880268, ECO:0000269|PubMed:19909775, ECO:0000269|PubMed:7744009}. Cytoplasm {ECO:0000269|PubMed:16880268}. Note=Detected in the cytoplasm of the zygote (PubMed:16880268). Translocates into the pronucleus at the time of genome activation (PubMed:16880268). Colocalizes with sites of active transcription (PubMed:10610177). Localizes to sites of DNA damage (By similarity). {ECO:0000250|UniProtKB:O15164, ECO:0000269|PubMed:10610177, ECO:0000269|PubMed:16880268}.
uniprot
proteins