Kbtbd2
entrez
210973
canonical
uniprot
G3X9X1
canonical
ensembl
ENSMUSG00000059486
resolver
ensp
ENSMUSP00000109960
resolver
ensp
ENSMUSP00000109962
resolver
ensp
ENSMUSP00000316588
resolver
ensp
ENSMUSP00000316589
resolver
ensp
ENSMUSP00000316590
resolver
enst
ENSMUST00000114321
resolver
enst
ENSMUST00000114323
resolver
genesymbol
Kbtbd2
resolver
genesymbol_syn
mKIAA1489
resolver
uniprot
Q6ZPP6
resolver
uniprot_entry
KBTB2_MOUSE
resolver
uniprot_entry
Q6ZPP6_MOUSE
resolver
amino_acid_sequence
MSTQEERQINTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAAALQMIIAYAYTGNLAVNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYRQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQGLYKSMPKFFKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRVKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNERAKYVTYQYDLELDRWSLRQHISERVLWDLGRDFRCTVGKLYPSCLEESPWKPPTYLFSPDGTEEFELDGEMVALPPV
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation. {ECO:0000269|PubMed:27708159, ECO:0000269|PubMed:32381739}.
uniprot
proteins
mass_dalton
71286
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:27708159}.
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27708159
uniprot
proteins
pubmed
32381739
uniprot
proteins
sequence_length
623
uniprot
proteins