FIGNL2
entrez
401720
canonical
uniprot
A6NMB9
canonical
ensembl
ENSG00000261308
resolver
ensp
ENSP00000491257
resolver
ensp
ENSP00000608564
resolver
ensp
ENSP00000618652
resolver
enst
ENST00000618634
resolver
enst
ENST00000938505
resolver
enst
ENST00000948593
resolver
genesymbol
FIGNL2
resolver
hgnc
HGNC:13287
resolver
uniprot
Q6ZP58
resolver
uniprot_entry
FIGL2_HUMAN
resolver
uniprot_entry
Q6ZP58_HUMAN
resolver
amino_acid_sequence
MHWTPEHAQPLNQWPEQHLDVSSTTPSPAHKLELPPGGRQRCHYAWAHDDISALTASNLLKRYAEKYSGVLDSPYERPALGGYSDASFLNGAKGDPEPWPGPEPPYPLASLHEGLPGTKSGGGGGSGALGGSPVLAGNLPEPLYAGNACGGPSAAPEYAAGYGGGYLAPGYCAQTGAALPPPPPAALLQPPPPPGYGPSAPLYNYPAGGYAAQPGYGALPPPPGPPPAPYLTPGLPAPTPLPAPAPPTAYGFPTAAPGAESGLSLKRKAADEGPEGRYRKYAYEPAKAPVADGASYPAADNGECRGNGFRAKPPGAAEEASGKYGGGVPLKVLGSPVYGPQLEPFEKFPERAPAPRGGFAVPSGETPKGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGAAAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQLCQQAAAGAGLPGLQRPLSYKDLEAALAKVGPRASAKELDSFVEWDKMYGSGH
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Microtubule-severing enzyme that negatively regulates cell migration and wound healing (PubMed:25756798, PubMed:36523161). In migrating cells, targets dynamic microtubules (MTs) at the leading edge and severs them, thereby suppressing motility (PubMed:25756798, PubMed:36523161). Microtubule severing releases ARHGEF2 which activates RHOA, which in turn regulates focal ahesion turnover via focal adhesion kinase, as opposed to F-actin polymerization, to suppress cell motility (PubMed:36523161). Negative regulator of axon regeneration that suppresses axonal growth by selectively severing dynamic MTs in the distal axon shaft and growth cone (By similarity). Contributes to proper cell branching during endothelial and neuronal development (By similarity). {ECO:0000250|UniProtKB:E9QEA3, ECO:0000250|UniProtKB:J3QK54, ECO:0000269|PubMed:25756798, ECO:0000269|PubMed:36523161}.
uniprot
proteins
mass_dalton
66603
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
25756798
uniprot
proteins
pubmed
36523161
uniprot
proteins
sequence_length
653
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:J3QK54}. Cytoplasm, cell cortex {ECO:0000269|PubMed:25756798}. Note=Localizes at the leading edge of migrating cells. {ECO:0000269|PubMed:25756798}.
uniprot
proteins