KRT13
entrez
3860
canonical
uniprot
P13646
canonical
ensembl
ENSG00000171401
resolver
ensp
ENSP00000246635
resolver
ensp
ENSP00000336604
resolver
genesymbol
KRT13
resolver
hgnc
HGNC:6415
resolver
uniprot
A1A4E9
resolver
uniprot
Q53G54
resolver
uniprot
Q6AZK5
resolver
uniprot
Q8N240
resolver
uniprot_entry
A1A4E9_HUMAN
resolver
uniprot_entry
K1C13_HUMAN
resolver
uniprot_sec
Q53G54
resolver
uniprot_sec
Q6AZK5
resolver
uniprot_sec
Q8N240
resolver
amino_acid_sequence
MSLRLQSSSASYGGGFGGGSCQLGGGRGVSTCSTRFVSGGSAGGYGGGVSCGFGGGAGSGFGGGYGGGLGGGYGGGLGGGFGGGFAGGFVDFGACDGGLLTGNEKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRDKILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEAMAERNRRDAEEWFHTKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMIGFPSSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP
uniprot
proteins
disease_involvement
DISEASE: White sponge nevus 2 (WSN2) [MIM:615785]: A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved. {ECO:0000269|PubMed:10561721, ECO:0000269|PubMed:11379896, ECO:0000269|PubMed:14600690, ECO:0000269|PubMed:18616775, ECO:0000269|PubMed:25606422, ECO:0000269|PubMed:29476668, ECO:0000269|PubMed:7493031}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in mucosal stratified squamous epithelia. Forms heteropolymers with the type II keratin KRT4, assembling into keratin intermediate filament networks that provides structural integrity and mechanical stability of the mucosal epithelium (PubMed:7493031). Contributes to postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially through regulation of the G1/S phase cyclins CCNE1 and CCNE2 (By similarity). {ECO:0000250|UniProtKB:P08730, ECO:0000269|PubMed:7493031}.
uniprot
proteins
mass_dalton
49588
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; glycans consist of single N-acetylglucosamine residues. {ECO:0000269|PubMed:2474541}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
10561721
uniprot
proteins
pubmed
11379896
uniprot
proteins
pubmed
14600690
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18616775
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2474541
uniprot
proteins
pubmed
2475110
uniprot
proteins
pubmed
2477803
uniprot
proteins
pubmed
2483837
uniprot
proteins
pubmed
25606422
uniprot
proteins
pubmed
29476668
uniprot
proteins
pubmed
7493031
uniprot
proteins
pubmed
9714826
uniprot
proteins
sequence_length
458
uniprot
proteins