Opn4
entrez
192223
canonical
uniprot
Q8R456
canonical
ensembl
ENSRNOG00000053893
resolver
ensembl
ENSRNOG00055009127
resolver
ensembl
ENSRNOG00060014175
resolver
ensembl
ENSRNOG00065014265
resolver
ensp
ENSRNOP00000098459
resolver
ensp
ENSRNOP00055012365
resolver
ensp
ENSRNOP00060019369
resolver
ensp
ENSRNOP00065018309
resolver
enst
ENSRNOT00000120847
resolver
enst
ENSRNOT00055015448
resolver
enst
ENSRNOT00060024270
resolver
enst
ENSRNOT00065023536
resolver
genesymbol
Opn4
resolver
uniprot_entry
OPN4_RAT
resolver
amino_acid_sequence
MNSPSESRVPSSLTQDPSFTASPALLQGIWNSTQNISVRVQLLSVSPTTPGLQAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRNRGLRTPANMLIINLAVSDFLMSFTQAPVFFASSLYKKWLFGETGCKFYAFCGAVFGIVSMITLTAIAMDRYLVITRPLATIGMRSKRRTALVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYVTFTPLVRAYTMLLFCFVFFLPLLIIIFCYIFIFRAIRETGRACEGCGESPLRRRQWQRLQSEWKMAKVALIVILLFVLSWAPYSTVALVGFAGYSHILTPYMSSVPAVIAKASAIHNPIIYAITHPKYRAAIAQHLPCLGVLLGVSGQRSHPSLSYRSTHRSTLSSQSSDLSWISGQKRQESLGSESEVGWTDTETTAAWGAAQQASGQSFCSHDLEDGEVKAPSSPQEQKSKTPKTKRHLPSLDRRM
uniprot
proteins
function
FUNCTION: G protein-coupled photoreceptor that signals through the G(q/11) family of G proteins in response to light in intrinsically photosensitive retinal ganglion cells (ipRGCs). Can also activate other G proteins, including G(i/o) and G(s), depending on the cell type, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent signaling. Activation occurs when opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (By similarity). Acts as a bistable protein, allowing photoreversible regeneration of the cis-retinal chromophore after stimulation (By similarity). Contributes to non-image-forming visual response to light in ipRGCs, including the pupillary light reflex and the regulation of circadian rhythms. In M1 ipRGCs (non-image forming) subtypes, activates a G(q)-phospholipase C (PLC) signaling cascade leading to depolarization through opening of TRPC6/7 channels and decreased intrisic excitability. Mediates phototransduction in M4 ipRGCs (image forming) subtypes across dim to bright light conditions via G(q)-PLC signaling, resulting in increased intrisic excitability through closure of potassium leak channels (most likely TASK channels), thereby enhancing contrast sensitivity. At bright light intensities, further enhances depolarization in M4 ipRGCs via activation of TRPC channels. Functions in the iris to control the intrinsic pupillary light reflex in nocturnal/crepuscular non-primate mammals. May be involved in the optokinetic visual tracking response. May also play a role in regulating retinal hyaloid vessel growth and regression (By similarity). {ECO:0000250|UniProtKB:Q9QXZ9, ECO:0000250|UniProtKB:Q9UHM6}.
uniprot
proteins
mass_dalton
52407
uniprot
proteins
post_translational_modification
PTM: Contains one retinal chromophore covalently bound to a lysine residue via a Schiff base. Upon light absorption, the bound 11-cis-retinal isomerizes to all-trans-retinal. Following light exposure, all-trans-retinal is photoreconverted to 11-cis-retinal. {ECO:0000250|UniProtKB:Q9UHM6}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Opsin subfamily
uniprot
proteins
pubmed
11834834
uniprot
proteins
sequence_length
474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11834834}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QXZ9}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9QXZ9}. Perikaryon {ECO:0000250|UniProtKB:Q9QXZ9}.
uniprot
proteins
transmembrane_region
TRANSMEM 73..93; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 108..128; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 145..165; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 239..259; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 294..314; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 356..372; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins