MSRA
entrez
4482
canonical
uniprot
Q9UJ68
canonical
ensembl
ENSG00000175806
resolver
ensembl
ENSG00000285250
resolver
ensp
ENSP00000313921
resolver
ensp
ENSP00000371930
resolver
ensp
ENSP00000410912
resolver
ensp
ENSP00000436839
resolver
ensp
ENSP00000659335
resolver
ensp
ENSP00000787317
resolver
genesymbol
MSRA
resolver
hgnc
HGNC:7377
resolver
uniprot
E9PAS8
resolver
uniprot
Q52TC4
resolver
uniprot
Q549N4
resolver
uniprot
Q66MI7
resolver
uniprot_entry
MSRA_HUMAN
resolver
uniprot_sec
E9PAS8
resolver
uniprot_sec
Q52TC4
resolver
uniprot_sec
Q549N4
resolver
uniprot_sec
Q66MI7
resolver
amino_acid_sequence
MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAAKHHVNGNRTVEPFPEGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENHDPTQGMRQGNDHGTQYRSAIYPTSAKQMEAALSSKENYQKVLSEHGFGPITTDIREGQTFYYAEDYHQQYLSKNPNGYCGLGGTGVSCPVGIKK
uniprot
proteins
ec_number
1.8.4.11
uniprot
proteins
function
FUNCTION: [Isoform 1]: Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Has an important function as a repair enzyme for proteins that have been inactivated by oxidation (PubMed:10452521, PubMed:12039877). Plays a crucial role in repairing oxidized methionine residues in key lens proteins, such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS), thereby restoring their function and maintaining lens transparency (By similarity). {ECO:0000250|UniProtKB:Q9D6Y7, ECO:0000269|PubMed:10452521, ECO:0000269|PubMed:12039877}.
uniprot
proteins
mass_dalton
26132
uniprot
proteins
mutagenesis
MUTAGEN 6; /note="R->A: Impaired subcellular location."; /evidence="ECO:0000269|PubMed:12039877"; MUTAGEN 7; /note="R->A: Impaired subcellular location."; /evidence="ECO:0000269|PubMed:12039877"; MUTAGEN 11..13; /note="Missing: Impaired subcellular location."; /evidence="ECO:0000269|PubMed:12039877"; MUTAGEN 22; /note="R->A: Impaired subcellular location."; /evidence="ECO:0000269|PubMed:12039877
uniprot
proteins
protein_family
MsrA Met sulfoxide reductase family
uniprot
proteins
pubmed
10452521
uniprot
proteins
pubmed
12039877
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16364291
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
20368336
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25807930
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:16364291}. Mitochondrion matrix {ECO:0000269|PubMed:12039877}. Cytoplasm {ECO:0000269|PubMed:16364291}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16364291}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:16364291}. Nucleus {ECO:0000269|PubMed:16364291}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
uniprot
proteins