SLC10A2
entrez
6555
canonical
uniprot
Q12908
canonical
ensembl
ENSG00000125255
resolver
ensp
ENSP00000245312
resolver
enst
ENST00000245312
resolver
genesymbol
SLC10A2
resolver
genesymbol_syn
ASBT
resolver
genesymbol_syn
ISBT
resolver
genesymbol_syn
NTCP2
resolver
hgnc
HGNC:10906
resolver
uniprot
A1L4F4
resolver
uniprot
Q13839
resolver
uniprot_entry
NTCP2_HUMAN
resolver
uniprot_sec
A1L4F4
resolver
uniprot_sec
Q13839
resolver
amino_acid_sequence
MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMGCNVEIKKFLGHIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLIIGCCPGGTASNILAYWVDGDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVSLVVPVSIGMFVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYSLGFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAFAAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK
uniprot
proteins
disease_involvement
DISEASE: Bile acid malabsorption, primary, 1 (PBAM1) [MIM:613291]: An autosomal recessive intestinal disorder associated with chronic watery diarrhea, excess fecal bile acids, steatorrhea and interruption of the enterohepatic circulation of bile acids. {ECO:0000269|PubMed:9109432}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:7592981, PubMed:9458785, PubMed:9856990). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:7592981, PubMed:9458785, PubMed:9856990). Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321). {ECO:0000269|PubMed:7592981, ECO:0000269|PubMed:9458785, ECO:0000269|PubMed:9856990, ECO:0000303|PubMed:33222321, ECO:0000305|PubMed:9458785}.
uniprot
proteins
mass_dalton
37714
uniprot
proteins
mutagenesis
MUTAGEN 10; /note="N->D: Abolishes glycosylation."; /evidence="ECO:0000269|PubMed:15350125"; MUTAGEN 328; /note="N->D: No effect on glycosylation."; /evidence="ECO:0000269|PubMed:15350125
uniprot
proteins
protein_family
Bile acid:sodium symporter (BASS) (TC 2.A.28) family
uniprot
proteins
pubmed
11589382
uniprot
proteins
pubmed
11742882
uniprot
proteins
pubmed
12364586
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15350125
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
33222321
uniprot
proteins
pubmed
7592981
uniprot
proteins
pubmed
9109432
uniprot
proteins
pubmed
9458785
uniprot
proteins
pubmed
9856990
uniprot
proteins
sequence_length
348
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 29..49; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 83..103; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 285..305; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins