Syt2
entrez
24805
canonical
uniprot
P29101
canonical
ensembl
ENSRNOG00000004756
resolver
ensembl
ENSRNOG00055021595
resolver
ensembl
ENSRNOG00060014883
resolver
ensembl
ENSRNOG00065021046
resolver
ensp
ENSRNOP00000006637
resolver
ensp
ENSRNOP00055030009
resolver
ensp
ENSRNOP00060020286
resolver
ensp
ENSRNOP00065028826
resolver
enst
ENSRNOT00000006637
resolver
enst
ENSRNOT00055036921
resolver
enst
ENSRNOT00060025448
resolver
enst
ENSRNOT00065035765
resolver
genesymbol
Syt2
resolver
uniprot
G3V6M3
resolver
uniprot_entry
G3V6M3_RAT
resolver
uniprot_entry
SYT2_RAT
resolver
amino_acid_sequence
MRNIFKRNQEPIVAPATTTATMPLAPAAPADNSTESTGTGESQEDMFAKLKDKFFNEINKIPLPPWALIAMAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK
uniprot
proteins
function
FUNCTION: Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Plays a role in dendrite formation by melanocytes. {ECO:0000250|UniProtKB:P46097, ECO:0000250|UniProtKB:Q8N9I0}.; FUNCTION: (Microbial infection) Receptor for C.botulinum neurotoxin type B (BoNT/B, botB); unlike the case with BoNT/B interaction is not improved in the presence of gangliosides (PubMed:17167421). The toxin binds to the vesicular domain of Syt2 (residues 1-61) (PubMed:15123599). {ECO:0000269|PubMed:15123599}.; FUNCTION: (Microbial infection) Receptor for C.botulinum neurotoxin type G (BoNT/G, botG); unlike the case with BoNT/B interaction is not improved in the presence of gangliosides (PubMed:15123599). The toxin binds to the vesicular domain of Syt2 (residues 1-61) (PubMed:15123599). {ECO:0000269|PubMed:15123599}.
uniprot
proteins
mass_dalton
47210
uniprot
proteins
mutagenesis
MUTAGEN 46; /note="M->A: Nearly wild-type binding of fragment 1-61 to BoNT/B heavy chain."; /evidence="ECO:0000269|PubMed:17167421"; MUTAGEN 47; /note="F->A: No binding of fragment 1-61 to BoNT/B heavy chain."; /evidence="ECO:0000269|PubMed:17167421"; MUTAGEN 50; /note="L->A: Decreased binding of fragment 1-61 to BoNT/B heavy chain."; /evidence="ECO:0000269|PubMed:17167421"; MUTAGEN 54; /note="F->A: No binding of fragment 1-61 to BoNT/B heavy chain."; /evidence="ECO:0000269|PubMed:17167421"; MUTAGEN 55; /note="F->A: No binding of fragment 1-61 to BoNT/B heavy chain."; /evidence="ECO:0000269|PubMed:17167421"; MUTAGEN 57; /note="E->K: No binding of fragment 1-61 to BoNT/B heavy chain."; /evidence="ECO:0000269|PubMed:17167421"; MUTAGEN 59; /note="N->H: Nearly wild-type binding of fragment 1-61 to BoNT/B heavy chain."; /evidence="ECO:0000269|PubMed:17167421"; MUTAGEN 202; /note="T->A: Decreased phosphorylation by WNK1."; /evidence="ECO:0000269|PubMed:15350218"; MUTAGEN 231; /note="D->S: Impaired calcium-binding and phosphorylation by WNK1."; /evidence="ECO:0000269|PubMed:15350218"; MUTAGEN 310; /note="D->N: Impaired calcium-binding and phosphorylation by WNK1."; /evidence="ECO:0000269|PubMed:15350218"; MUTAGEN 386; /note="T->A: Decreased phosphorylation by WNK1."; /evidence="ECO:0000269|PubMed:15350218
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-202 by WNK1, changes the calcium requirement for SYT2-binding to phospholipid membranes. {ECO:0000269|PubMed:15350218}.
uniprot
proteins
protein_family
Synaptotagmin family
uniprot
proteins
pubmed
11823420
uniprot
proteins
pubmed
15123599
uniprot
proteins
pubmed
15350218
uniprot
proteins
pubmed
17167421
uniprot
proteins
pubmed
1856191
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9867811
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:9867811}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein. Cytoplasm.
uniprot
proteins
transmembrane_region
TRANSMEM 61..87; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins