SULF2
entrez
55959
canonical
uniprot
Q8IWU5
canonical
ensembl
ENSG00000196562
resolver
ensp
ENSP00000353007
resolver
ensp
ENSP00000418290
resolver
ensp
ENSP00000418442
resolver
ensp
ENSP00000508753
resolver
ensp
ENSP00000529511
resolver
ensp
ENSP00000529512
resolver
ensp
ENSP00000529514
resolver
ensp
ENSP00000529518
resolver
ensp
ENSP00000587887
resolver
ensp
ENSP00000739450
resolver
genesymbol
SULF2
resolver
genesymbol_syn
KIAA1247
resolver
hgnc
HGNC:20392
resolver
uniprot
E1P5U6
resolver
uniprot
Q5JYE1
resolver
uniprot
Q6UX86
resolver
uniprot
Q96SG2
resolver
uniprot
Q9H1H0
resolver
uniprot
Q9UJR3
resolver
uniprot
Q9ULH3
resolver
uniprot_entry
SULF2_HUMAN
resolver
uniprot_sec
E1P5U6
resolver
uniprot_sec
Q5JYE1
resolver
uniprot_sec
Q6UX86
resolver
uniprot_sec
Q96SG2
resolver
uniprot_sec
Q9H1H0
resolver
uniprot_sec
Q9UJR3
resolver
uniprot_sec
Q9ULH3
resolver
amino_acid_sequence
MGPPSLVLCLLSATVFSLLGGSSAFLSHHRLKGRFQRDRRNIRPNIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVKEKHGSDYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGCLNPHIVLNIDLAPTILDIAGLDIPADMDGKSILKLLDTERPVNRFHLKKKMRVWRDSFLVERGKLLHKRDNDKVDAQEENFLPKYQRVKDLCQRAEYQTACEQLGQKWQCVEDATGKLKLHKCKGPMRLGGSRALSNLVPKYYGQGSEACTCDSGDYKLSLAGRRKKLFKKKYKASYVRSRSIRSVAIEVDGRVYHVGLGDAAQPRNLTKRHWPGAPEDQDDKDGGDFSGTGGLPDYSAANPIKVTHRCYILENDTVQCDLDLYKSLQAWKDHKLHIDHEIETLQNKIKNLREVRGHLKKKRPEECDCHKISYHTQHKGRLKHRGSSLHPFRKGLQEKDKVWLLREQKRKKKLRKLLKRLQNNDTCSMPGLTCFTHDNQHWQTAPFWTLGPFCACTSANNNTYWCMRTINETHNFLFCEFATGFLEYFDLNTDPYQLMNAVNTLDRDVLNQLHVQLMELRSCKGYKQCNPRTRNMDLGLKDGGSYEQYRQFQRRKWPEMKRPSSKSLGQLWEGWEG
uniprot
proteins
ec_number
3.1.6.1
uniprot
proteins
ec_number
3.1.6.14
uniprot
proteins
function
FUNCTION: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:30788513, PubMed:35294879). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:30788513, PubMed:35294879). {ECO:0000269|PubMed:12368295, ECO:0000269|PubMed:30788513, ECO:0000269|PubMed:35294879}.
uniprot
proteins
mass_dalton
100455
uniprot
proteins
mutagenesis
MUTAGEN 88..89; /note="CC->AA: Loss of arylsulfatase activity."; /evidence="ECO:0000269|PubMed:12368295"; MUTAGEN 180..182; /note="KEK->AEA: No effect on N-acetylglucosamine-6-sulfatase activity. Significant loss of N-acetylglucosamine-6-sulfatase activity; when associated with 402-A--A-404."; /evidence="ECO:0000269|PubMed:30788513"; MUTAGEN 402..404; /note="KKK->AAA: No effect on N-acetylglucosamine-6-sulfatase activity. Significant loss of N-acetylglucosamine-6-sulfatase activity; when associated with 180-A--A-182."; /evidence="ECO:0000269|PubMed:30788513
uniprot
proteins
post_translational_modification
PTM: Processing by furin produces a secreted form. {ECO:0000269|PubMed:12368295, ECO:0000269|PubMed:30788513, ECO:0000269|PubMed:35294879}.; PTM: Glycosylation at Ser-583 negatively regulates its N-acetylglucosamine-6-sulfatase and arylsulfatase activities. {ECO:0000269|PubMed:35294879}.; PTM: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. {ECO:0000250|UniProtKB:P15289}.
uniprot
proteins
protein_family
Sulfatase family
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12368295
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
30788513
uniprot
proteins
pubmed
35294879
uniprot
proteins
sequence_length
870
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8VI60}. Golgi apparatus, Golgi stack {ECO:0000250|UniProtKB:Q8VI60}. Cell surface {ECO:0000269|PubMed:12368295, ECO:0000269|PubMed:35294879}.; SUBCELLULAR LOCATION: [Extracellular sulfatase Sulf-2 secreted form]: Secreted {ECO:0000269|PubMed:12368295, ECO:0000269|PubMed:30788513, ECO:0000269|PubMed:35294879}.
uniprot
proteins