Pcgf2
entrez
22658
canonical
uniprot
P23798
canonical
ensembl
ENSMUSG00000018537
resolver
ensp
ENSMUSP00000018681
resolver
ensp
ENSMUSP00000099437
resolver
ensp
ENSMUSP00000126967
resolver
ensp
ENSMUSP00000137517
resolver
ensp
ENSMUSP00000319331
resolver
ensp
ENSMUSP00000319332
resolver
ensp
ENSMUSP00000347945
resolver
enst
ENSMUST00000018681
resolver
enst
ENSMUST00000103148
resolver
enst
ENSMUST00000169807
resolver
enst
ENSMUST00000179765
resolver
genesymbol
Pcgf2
resolver
genesymbol_syn
Mel-18
resolver
genesymbol_syn
Mel18
resolver
genesymbol_syn
Rnf110
resolver
genesymbol_syn
Zfp144
resolver
genesymbol_syn
Znf144
resolver
uniprot_entry
PCGF2_MOUSE
resolver
amino_acid_sequence
MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPNGSNEDRGEVLEQEKGALGDDEIVSLSIEFYEGVRDREEKKNLTENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEILYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYRVQPACKRLTLPTVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPATHPTSPTPPSTAAGTTTATNGGTSNCLQTPSSTSRGRKMTVNGAPCPP
uniprot
proteins
disease_involvement
DISEASE: Note=Probably related to tumorigenesis since it is expressed strongly in most tumor cell lines.
uniprot
proteins
function
FUNCTION: Transcriptional repressor (PubMed:8521824). Binds specifically to the DNA sequence 5'-GACTNGACT-3' (PubMed:8521824). Has tumor suppressor activity (PubMed:8521824). May play a role in control of cell proliferation and/or neural cell development (Probable). Regulates proliferation of early T progenitor cells by maintaining expression of HES1 (PubMed:15728456). Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (PubMed:15183898, PubMed:8625838). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). {ECO:0000250|UniProtKB:P35227, ECO:0000269|PubMed:11750047, ECO:0000269|PubMed:15183898, ECO:0000269|PubMed:15728456, ECO:0000269|PubMed:8521824, ECO:0000269|PubMed:8625838, ECO:0000305}.
uniprot
proteins
mass_dalton
37723
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Homodimer formation is regulated by phosphorylation with only unphosphorylated proteins forming homodimers. {ECO:0000269|PubMed:12480532}.
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
11750047
uniprot
proteins
pubmed
12480532
uniprot
proteins
pubmed
15183898
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15728456
uniprot
proteins
pubmed
16024804
uniprot
proteins
pubmed
22226355
uniprot
proteins
pubmed
2246278
uniprot
proteins
pubmed
8521824
uniprot
proteins
pubmed
8625838
uniprot
proteins
sequence_length
342
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:2246278}.
uniprot
proteins