Cacng2
entrez
84347
canonical
uniprot
Q71RJ2
canonical
ensembl
ENSRNOG00000065511
resolver
ensembl
ENSRNOG00055032050
resolver
ensembl
ENSRNOG00060029610
resolver
ensembl
ENSRNOG00065033086
resolver
ensp
ENSRNOP00000085982
resolver
ensp
ENSRNOP00055045747
resolver
ensp
ENSRNOP00060042785
resolver
ensp
ENSRNOP00065046863
resolver
enst
ENSRNOT00000106728
resolver
enst
ENSRNOT00055055426
resolver
enst
ENSRNOT00060051430
resolver
enst
ENSRNOT00065056922
resolver
genesymbol
Cacng2
resolver
genesymbol_syn
Stg
resolver
uniprot
Q99PR9
resolver
uniprot_entry
CCG2_RAT
resolver
uniprot_entry
Q99PR9_RAT
resolver
amino_acid_sequence
MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGVKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKDSKDSLHANTANRRTTPV
uniprot
proteins
function
FUNCTION: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000269|PubMed:17880894, ECO:0000269|PubMed:18817736, ECO:0000269|PubMed:19234459, ECO:0000269|PubMed:19265014, ECO:0000269|PubMed:20805473}.
uniprot
proteins
mass_dalton
35895
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-321 by PKA impairs interaction with DLG1 and DLG4. {ECO:0000250}.
uniprot
proteins
protein_family
CACNG subfamily
uniprot
proteins
protein_family
PMP-22/EMP/MP20 family
uniprot
proteins
pubmed
11738816
uniprot
proteins
pubmed
17880894
uniprot
proteins
pubmed
18817736
uniprot
proteins
pubmed
19234459
uniprot
proteins
pubmed
19265014
uniprot
proteins
pubmed
20805473
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
27756895
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Synapse, synaptosome {ECO:0000269|PubMed:27756895}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 134..154; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 182..202; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins