ACOT12
entrez
134526
canonical
uniprot
Q8WYK0
canonical
ensembl
ENSG00000172497
resolver
ensp
ENSP00000303246
resolver
ensp
ENSP00000655841
resolver
genesymbol
ACOT12
resolver
genesymbol_syn
CACH
resolver
genesymbol_syn
CACH1
resolver
genesymbol_syn
STARD15
resolver
hgnc
HGNC:24436
resolver
uniprot
B3KVK9
resolver
uniprot
Q5FWE9
resolver
uniprot_entry
ACO12_HUMAN
resolver
uniprot_sec
B3KVK9
resolver
uniprot_sec
Q5FWE9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by ADP. Active in the presence of ATP (PubMed:16951743). Cold labile, it dissociates into inactive monomers at low temperature (By similarity). {ECO:0000250|UniProtKB:Q99NB7, ECO:0000269|PubMed:16951743}.
uniprot
proteins
amino_acid_sequence
MERPAPGEVVMSQAIQPAHATARGELSAGQLLKWIDTTACLAAEKHAGVSCVTASVDDIQFEETARVGQVITIKAKVTRAFSTSMEISIKVMVQDMLTGIEKLVSVAFSTFVAKPVGKEKIHLKPVTLLTEQDHVEHNLAAERRKVRLQHEDTFNNLMKESSKFDDLIFDEEEGAVSTRGTSVQSIELVLPPHANHHGNTFGGQIMAWMETVATISASRLCWAHPFLKSVDMFKFRGPSTVGDRLVFTAIVNNTFQTCVEVGVRVEAFDCQEWAEGRGRHINSAFLIYNAADDKENLITFPRIQPISKDDFRRYRGAIARKRIRLGRKYVISHKEEVPLCIHWDISKQASLSDSNVEALKKLAAKRGWEVTSTVEKIKIYTLEEHDVLSVWVEKHVGSPAHLAYRLLSDFTKRPLWDPHFVSCEVIDWVSEDDQLYHITCPILNDDKPKDLVVLVSRRKPLKDGNTYTVAVKSVILPSVPPSPQYIRSEIICAGFLIHAIDSNSCIVSYFNHMSASILPYFAGNLGGWSKSIEETAASCIQFLENPPDDGFVSTF
uniprot
proteins
ec_number
3.1.2.1
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16951743). Preferentially hydrolyzes acetyl-CoA (PubMed:16951743). {ECO:0000269|PubMed:16951743}.
uniprot
proteins
mass_dalton
62034
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000305|PubMed:16951743}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16951743
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
555
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16951743}.
uniprot
proteins