Sod3
entrez
25352
canonical
uniprot
Q08420
canonical
ensembl
ENSRNOG00000003869
resolver
ensembl
ENSRNOG00055011318
resolver
ensembl
ENSRNOG00060016186
resolver
ensembl
ENSRNOG00065003240
resolver
ensp
ENSRNOP00000005155
resolver
ensp
ENSRNOP00000098721
resolver
ensp
ENSRNOP00000100415
resolver
ensp
ENSRNOP00000101578
resolver
ensp
ENSRNOP00000107294
resolver
ensp
ENSRNOP00055015440
resolver
ensp
ENSRNOP00060022286
resolver
ensp
ENSRNOP00065003297
resolver
enst
ENSRNOT00000005155
resolver
enst
ENSRNOT00000123334
resolver
enst
ENSRNOT00000147562
resolver
enst
ENSRNOT00000150416
resolver
enst
ENSRNOT00000158055
resolver
enst
ENSRNOT00055019165
resolver
enst
ENSRNOT00060027730
resolver
enst
ENSRNOT00065004598
resolver
genesymbol
Sod3
resolver
genesymbol_syn
Sod-3
resolver
uniprot
Q64667
resolver
uniprot_entry
SODE_RAT
resolver
uniprot_sec
Q64667
resolver
amino_acid_sequence
MVAFLFCNLLLVACGSVTWTMSDTGESGVDLADRLDLVEKIGDTHSKDLEIWMELGKQREADAREMHAVCRVQPSAMLPPDQPQITGLVLFRQLGPSSRLEASFNLEGFPAEQNTSNHAIHVHEFGDLSQGCESTGPHYNPLGVPHPQHPGDFGNFVVRDGRLWKHRMGLATSLAGPHSILGRAVVVHAGEDDLGKGGNQASVQNGNAGRRLACCVVGTSNSEAWESQTKERKKRRRESECKTT
uniprot
proteins
ec_number
1.15.1.1
uniprot
proteins
function
FUNCTION: Secreted antioxidant enzyme that acts as the primary scavenger of superoxide radicals in the extracellular space, converting them to hydrogen peroxide and thereby protecting tissues from oxidative damage. Also preserves nitric oxide bioavailability by preventing the formation of harmful peroxynitrite. Stored in intracellular pre-formed vesicles of macrophages and neutrophils and released upon stimulation by inflammatory mediators. {ECO:0000250|UniProtKB:P08294}.
uniprot
proteins
mass_dalton
26620
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="D->V: Homotetramerization."; /evidence="ECO:0000269|PubMed:8643556
uniprot
proteins
protein_family
Cu-Zn superoxide dismutase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8227019
uniprot
proteins
pubmed
8328962
uniprot
proteins
pubmed
8643556
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250|UniProtKB:P08294}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O09164}. Vesicle {ECO:0000250|UniProtKB:P08294}. Note=99% of SOD3/EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium. In macrophages and neutrophiles, extracellular SOD2 in endocytosed and stored in intracellular vesicles. {ECO:0000250|UniProtKB:P08294}.
uniprot
proteins