Cd83
entrez
12522
canonical
uniprot
O88324
canonical
ensembl
ENSMUSG00000015396
resolver
ensp
ENSMUSP00000015540
resolver
ensp
ENSMUSP00000238305
resolver
enst
ENSMUST00000015540
resolver
genesymbol
Cd83
resolver
uniprot_entry
CD83_MOUSE
resolver
amino_acid_sequence
MSQGLQLLFLGCACSLAPAMAMREVTVACSETADLPCTAPWDPQLSYAVSWAKVSESGTESVELPESKQNSSFEAPRRRAYSLTIQNTTICSSGTYRCALQELGGQRNLSGTVVLKVTGCPKEATESTFRKYRAEAVLLFSLVVFYLTLIIFTCKFARLQSIFPDISKPGTEQAFLPVTSPSKHLGPVTLPKTETV
uniprot
proteins
function
FUNCTION: Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHC II trafficking MARCHF8 (PubMed:27503071, PubMed:27503069). Also inhibits MARCHF1 association with MHC II and ubiquitination of MHCII (By similarity). In addition, acts as an important modulator of protective responses against acute infections (PubMed:31527313). {ECO:0000250|UniProtKB:Q01151, ECO:0000269|PubMed:27503069, ECO:0000269|PubMed:27503071, ECO:0000269|PubMed:31527313}.
uniprot
proteins
mass_dalton
21313
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
27503069
uniprot
proteins
pubmed
27503071
uniprot
proteins
pubmed
31527313
uniprot
proteins
pubmed
9799334
uniprot
proteins
sequence_length
196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 134..154; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins