Kw 1225
cv_term_accession
KW-1225
canonical
uniprot_keyword
KW-1225
canonical
name
Inhibition of host TLR pathway by virus
uniprot
definition
Viral protein involved in the evasion of host innate defenses by inhibiting the Toll-like recognition receptor (TLR) pathway. This pathway usually starts with the recognition of viruses by host TLRs including TLR3 or TLR4. Then, the signal is transmitted through MYD88 (or TRIF) and then to TBK1 leading to the activation and nuclear localization of transcription factors IRF3 and/or IRF7 to induce IFNalpha/beta transcription and production of proinflammatory cytokines through activation of the NF-kappaB signaling pathway. Many viruses interact with components of this pathway to inhibit production of interferons and establishment of the antiviral state.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
uniprot_keywords
uniprot
keywords