Gmnn
entrez
57441
canonical
uniprot
O88513
canonical
ensembl
ENSMUSG00000006715
resolver
ensp
ENSMUSP00000006898
resolver
ensp
ENSMUSP00000106011
resolver
ensp
ENSMUSP00000135823
resolver
enst
ENSMUST00000006898
resolver
enst
ENSMUST00000110382
resolver
genesymbol
Gmnn
resolver
uniprot
Q3V295
resolver
uniprot_entry
GEMI_MOUSE
resolver
uniprot_entry
Q3V295_MOUSE
resolver
amino_acid_sequence
MNLSMKQKQEGAQENVKNSPVPRRTLKMIQPSADGSLVGRENELPKGLFKRKLWDDQLASQTSSCGPEANENKDVGDLTQEAFDLISKENPSSQYWKEVAEQRRKALYEALKENEKLHKEIEQKDSEIARLRKENKDLAEVAEHVQYMAEVIERLSNEPLDNFESPDSQEFDSEEEAVEYSELEDSGAGTCAEETVSSSTDARPCT
uniprot
proteins
function
FUNCTION: Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:12192004, PubMed:9635433). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:12192004, PubMed:9635433). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (By similarity). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (By similarity). {ECO:0000250|UniProtKB:O75496, ECO:0000269|PubMed:12192004, ECO:0000269|PubMed:9635433}.
uniprot
proteins
mass_dalton
23300
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during mitosis. Phosphorylation at Ser-181 by CK2 results in enhanced binding to Hox proteins and more potent inhibitory effect on Hox transcriptional activity. {ECO:0000250|UniProtKB:O75496}.
uniprot
proteins
protein_family
Geminin family
uniprot
proteins
pubmed
12192004
uniprot
proteins
pubmed
15286659
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15811859
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9635433
uniprot
proteins
sequence_length
206
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O75496}. Nucleus {ECO:0000250|UniProtKB:O75496}. Note=Mainly cytoplasmic but can be relocalized to the nucleus. {ECO:0000250|UniProtKB:O75496}.
uniprot
proteins