Rnf187
entrez
108660
canonical
uniprot
Q8BFX1
canonical
ensembl
ENSMUSG00000020496
resolver
ensp
ENSMUSP00000091703
resolver
enst
ENSMUST00000094151
resolver
genesymbol
Rnf187
resolver
uniprot
Q4VA64
resolver
uniprot
Q8C2B0
resolver
uniprot
Q8CAS0
resolver
uniprot
Q9JMF6
resolver
uniprot_entry
RN187_MOUSE
resolver
uniprot_sec
Q4VA64
resolver
uniprot_sec
Q8C2B0
resolver
uniprot_sec
Q8CAS0
resolver
uniprot_sec
Q9JMF6
resolver
amino_acid_sequence
MALPAGPADAICALCQRAPREPVRADCGHRFCRACVVRFWAEEDGPFPCPECADDCWQRAVEPSRPPLSRRLLALEEAAAAPARDGPASEAALQLLCRADGDPLCSACRMAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVMDRRKKALTDYKKLRAFFVEEEEHFLQEAEKDEGASEDDELADPADRFRSLLQAVSELEKKHRNLGLSMLLQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8. {ECO:0000250|UniProtKB:Q5TA31}.
uniprot
proteins
mass_dalton
26313
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; undergoes 'Lys-48'-linked autoubiquitination in the absence of growth factors and MAP3K1-induced 'Lys-63'-linked polyubiquitination. 'Lys-48'-autoubiquitination leads to degradation by the proteasome, while MAP3K1-induced 'Lys-63'-linked polyubiquitination results in the stabilization of the protein. 'Lys-48'- and 'Lys-63'-linked polyubiquitinations occur most probably on the same 3 C-terminal lysine residues (Lys-195, Lys-224 and Lys-225) and are thus mutually exclusive. Other sites of ubiquitination are not excluded. 'Lys-63'-linked polyubiquitination by TRIM7 in response to growth factor signaling via the MEK/ERK pathway enhances protein stability. {ECO:0000250|UniProtKB:Q5TA31}.; PTM: Arginine methylation by PRMT1 stabilizes RNF187 by facilitating K63-linked ubiquitin chain formation, and enables dimerization, c-Jun interaction and subsequent AP1 target gene expression. {ECO:0000250|UniProtKB:Q5TA31}.
uniprot
proteins
pubmed
10679242
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20852630
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5TA31}. Nucleus {ECO:0000250|UniProtKB:Q5TA31}. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250|UniProtKB:Q5TA31}.
uniprot
proteins