FBXO39
entrez
162517
canonical
uniprot
Q8N4B4
canonical
ensembl
ENSG00000177294
resolver
ensp
ENSP00000321386
resolver
enst
ENST00000321535
resolver
genesymbol
FBXO39
resolver
genesymbol_syn
FBX39
resolver
hgnc
HGNC:28565
resolver
uniprot_entry
FBX39_HUMAN
resolver
amino_acid_sequence
MDEESELIQPQDQSCWAFLPDLCLCRVFWWLGDRDRSRAALVCRKWNQMMYSAELWRYRTITFSGRPSRVHASEVESAVWYVKKFGRYLEHLEVKFMNPYNAVLTKKFQVTMRGLLSCLSKSNNRLKSLSIQYLELDRLVWRNSIRSSFISSLSFFLKKMGKRLDYLNLKGARLTVEQGCQILDSLSYMRNENVISELNIEDYFSHHLAVYNSPQFKKTMSTFHNLVSLNLNYNCISDELLENLCENASTLRTINIKCHVHDPHGQVIWGMSWAKLARQATNLKVNFFFERIMKYERLARILLQEIPIRSISLRSCYFSDPDCSMRPTLIDLLPTFRHTLQKLTCEFNNNHESLDEELHLLIISCRKLFYFKIWAFLDVSFVERILKSQKERQCALRVFKARIYTNRYETNEEDKTLQEIYRKYRKLIESELSYFVIVYSVM
uniprot
proteins
function
FUNCTION: Testis-enriched substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Acts as a critical regulator of spermatogenesis, maintaining mitochondrial homeostasis to inhibit ferroptotic cell death. Mechanistically, targets lysine-specific demethylase 5A (KDM5A) for ubiquitin-dependent degradation. {ECO:0000250|UniProtKB:Q5NBU5}.
uniprot
proteins
mass_dalton
52646
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
442
uniprot
proteins