LYNX1
entrez
66004
canonical
uniprot
P0DP58
canonical
ensembl
ENSG00000180155
resolver
ensembl
ENSG00000284505
resolver
ensp
ENSP00000478390
resolver
ensp
ENSP00000478402
resolver
ensp
ENSP00000498325
resolver
genesymbol
LYNX1
resolver
hgnc
HGNC:29604
resolver
uniprot
A0A140VJN6
resolver
uniprot
D3DWI7
resolver
uniprot
G3XAC2
resolver
uniprot
Q86SR0
resolver
uniprot
Q9BZG9
resolver
uniprot_entry
LYNX1_HUMAN
resolver
uniprot_sec
A0A140VJN6
resolver
uniprot_sec
D3DWI7
resolver
uniprot_sec
G3XAC2
resolver
uniprot_sec
Q86SR0
resolver
uniprot_sec
Q9BZG9
resolver
amino_acid_sequence
MTPLLTLILVVLMGLPLAQALDCHVCAYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCFETVYDGYSKHASTTSCCQYDLCNGTGLATPATLALAPILLATLWGLL
uniprot
proteins
function
FUNCTION: Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) (PubMed:21252236). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR (By similarity). In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs (PubMed:28100642). Prevents plasticity in the primary visual cortex late in life (By similarity). {ECO:0000250|UniProtKB:P0DP60, ECO:0000269|PubMed:21252236, ECO:0000269|PubMed:28100642}.
uniprot
proteins
mass_dalton
12641
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
21252236
uniprot
proteins
pubmed
24613312
uniprot
proteins
pubmed
26033490
uniprot
proteins
pubmed
28100642
uniprot
proteins
sequence_length
116
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:P0DP60}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P0DP60}. Note=Detected in Purkinje cells soma and proximal dendrites. {ECO:0000250|UniProtKB:P0DP60}.
uniprot
proteins