Il18
entrez
29197
canonical
uniprot
P97636
canonical
ensembl
ENSRNOG00000009848
resolver
ensp
ENSRNOP00000082676
resolver
genesymbol
Il18
resolver
genesymbol_syn
Igif
resolver
uniprot
O88749
resolver
uniprot
P97637
resolver
uniprot
Q541E6
resolver
uniprot_entry
IL18_RAT
resolver
uniprot_sec
O88749
resolver
uniprot_sec
P97637
resolver
uniprot_sec
Q541E6
resolver
amino_acid_sequence
MAAMSEEGSCVNFKEMMFIDNTLYLIPEDNGDLESDHFGRLHCTTAVIRSINDQVLFVDKRNPPVFEDMPDIDRTANESQTRLIIYMYKDSEVRGLAVTLSVKDGRMSTLSCKNKIISFEEMNPPENIDDIKSDLIFFQKRVPGHNKMEFESSLYEGHFLACQKEDDAFKLVLKRKDENGDKSVMFTLTNLHQS
uniprot
proteins
function
FUNCTION: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. {ECO:0000250|UniProtKB:Q14116}.
uniprot
proteins
mass_dalton
22303
uniprot
proteins
post_translational_modification
PTM: The pro-IL-18 precursor is processed by CASP1 to yield its mature, active form. The pro-IL-18 precursor is however not processed by Casp4/Casp11 in rodents (By similarity). The pro-IL-18 precursor features autoinhibitory interactions between the propeptide and the post-cleavage-site region, preventing recognition by the IL18R1 receptor. Processing by CASP1 induces conformational changes to generate critical receptor-binding sites. The mature form is then secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, cleavage by CASP3 inactivates IL18 (By similarity). {ECO:0000250|UniProtKB:P70380, ECO:0000250|UniProtKB:Q14116}.
uniprot
proteins
protein_family
IL-1 family
uniprot
proteins
pubmed
12787406
uniprot
proteins
pubmed
8999896
uniprot
proteins
pubmed
9702748
uniprot
proteins
sequence_length
194
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q14116}. Secreted {ECO:0000250|UniProtKB:Q14116}. Note=The precursor is cytosolic. In response to inflammasome-activating signals, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10. {ECO:0000250|UniProtKB:Q14116}.
uniprot
proteins