COMMD4
entrez
54939
canonical
uniprot
Q9H0A8
canonical
ensembl
ENSG00000140365
resolver
ensp
ENSP00000267935
resolver
ensp
ENSP00000340867
resolver
ensp
ENSP00000454283
resolver
ensp
ENSP00000455249
resolver
ensp
ENSP00000455750
resolver
ensp
ENSP00000457693
resolver
ensp
ENSP00000539698
resolver
ensp
ENSP00000598251
resolver
enst
ENST00000562789
resolver
enst
ENST00000564815
resolver
genesymbol
COMMD4
resolver
hgnc
HGNC:26027
resolver
uniprot
A0A0B4J287
resolver
uniprot
B2RBN4
resolver
uniprot
H3BQF2
resolver
uniprot
H3BUL2
resolver
uniprot
Q7L637
resolver
uniprot
Q9NX43
resolver
uniprot_entry
A0A0B4J287_HUMAN
resolver
uniprot_entry
COMD4_HUMAN
resolver
uniprot_entry
H3BQF2_HUMAN
resolver
uniprot_sec
B2RBN4
resolver
uniprot_sec
H3BUL2
resolver
uniprot_sec
Q7L637
resolver
uniprot_sec
Q9NX43
resolver
amino_acid_sequence
MRFRFCGDLDCPDWVLAEISTLAKMSSVKLRLLCSQVLKELLGQGIDYEKILKLTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSPLQKHLRVCSLRMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADKFQVLLAELKQAQTLMSSLG
uniprot
proteins
function
FUNCTION: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B (PubMed:23637203). {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129, ECO:0000305|PubMed:21778237}.
uniprot
proteins
mass_dalton
21764
uniprot
proteins
protein_family
COMM domain-containing protein 4 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15799966
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21778237
uniprot
proteins
pubmed
23563313
uniprot
proteins
pubmed
23637203
uniprot
proteins
pubmed
25355947
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
37172566
uniprot
proteins
pubmed
38459129
uniprot
proteins
pubmed
38504028
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21778237}. Nucleus {ECO:0000269|PubMed:21778237}.
uniprot
proteins