ING4
entrez
51147
canonical
uniprot
Q9UNL4
canonical
ensembl
ENSG00000111653
resolver
ensp
ENSP00000343396
resolver
ensp
ENSP00000380024
resolver
ensp
ENSP00000397343
resolver
ensp
ENSP00000412705
resolver
ensp
ENSP00000414008
resolver
ensp
ENSP00000415903
resolver
ensp
ENSP00000576817
resolver
ensp
ENSP00000576818
resolver
genesymbol
ING4
resolver
hgnc
HGNC:19423
resolver
uniprot
A4KYM4
resolver
uniprot
A4KYM6
resolver
uniprot
D3DUR8
resolver
uniprot
Q0EF62
resolver
uniprot
Q0EF63
resolver
uniprot
Q4VBQ6
resolver
uniprot
Q96E15
resolver
uniprot
Q9H3J0
resolver
uniprot_entry
ING4_HUMAN
resolver
uniprot_sec
A4KYM4
resolver
uniprot_sec
A4KYM6
resolver
uniprot_sec
D3DUR8
resolver
uniprot_sec
Q0EF62
resolver
uniprot_sec
Q0EF63
resolver
uniprot_sec
Q4VBQ6
resolver
uniprot_sec
Q96E15
resolver
uniprot_sec
Q9H3J0
resolver
amino_acid_sequence
MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLKQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGKKKGRTQKEKKAARARSKGKNSDEEAPKTAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK
uniprot
proteins
function
FUNCTION: Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). {ECO:0000250|UniProtKB:Q8C0D7, ECO:0000269|PubMed:15029197, ECO:0000269|PubMed:15251430, ECO:0000269|PubMed:15528276, ECO:0000269|PubMed:15897452, ECO:0000269|PubMed:16387653}.
uniprot
proteins
mass_dalton
28530
uniprot
proteins
post_translational_modification
PTM: Citrullination by PADI4 within the nuclear localization signal disrupts the interaction with p53 and increases susceptibility to degradation. {ECO:0000269|PubMed:21454715}.
uniprot
proteins
protein_family
ING family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
12750254
uniprot
proteins
pubmed
15029197
uniprot
proteins
pubmed
15251430
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15528276
uniprot
proteins
pubmed
15882981
uniprot
proteins
pubmed
15897452
uniprot
proteins
pubmed
16387653
uniprot
proteins
pubmed
16728974
uniprot
proteins
pubmed
16973615
uniprot
proteins
pubmed
17325660
uniprot
proteins
pubmed
18381289
uniprot
proteins
pubmed
19187765
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21454715
uniprot
proteins
pubmed
22334692
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15029197, ECO:0000269|PubMed:16973615}.
uniprot
proteins