Aire
entrez
11634
canonical
uniprot
Q9Z0E3
canonical
ensembl
ENSMUSG00000000731
resolver
ensp
ENSMUSP00000019257
resolver
ensp
ENSMUSP00000101034
resolver
ensp
ENSMUSP00000101035
resolver
ensp
ENSMUSP00000114904
resolver
ensp
ENSMUSP00000115162
resolver
ensp
ENSMUSP00000117094
resolver
ensp
ENSMUSP00000118317
resolver
ensp
ENSMUSP00000120150
resolver
ensp
ENSMUSP00000121477
resolver
ensp
ENSMUSP00000122190
resolver
ensp
ENSMUSP00000122659
resolver
genesymbol
Aire
resolver
uniprot
B2MVU6
resolver
uniprot
Q3ZB65
resolver
uniprot
Q3ZB71
resolver
uniprot
Q9JLW0
resolver
uniprot
Q9JLW1
resolver
uniprot
Q9JLW2
resolver
uniprot
Q9JLW3
resolver
uniprot
Q9JLW4
resolver
uniprot
Q9JLW5
resolver
uniprot
Q9JLW6
resolver
uniprot
Q9JLW7
resolver
uniprot
Q9JLW8
resolver
uniprot
Q9JLW9
resolver
uniprot
Q9JLX0
resolver
uniprot_entry
AIRE_MOUSE
resolver
uniprot_entry
B2MVU6_MOUSE
resolver
uniprot_entry
Q3ZB65_MOUSE
resolver
uniprot_entry
Q3ZB71_MOUSE
resolver
uniprot_sec
Q9JLW0
resolver
uniprot_sec
Q9JLW1
resolver
uniprot_sec
Q9JLW2
resolver
uniprot_sec
Q9JLW3
resolver
uniprot_sec
Q9JLW4
resolver
uniprot_sec
Q9JLW5
resolver
uniprot_sec
Q9JLW6
resolver
uniprot_sec
Q9JLW7
resolver
uniprot_sec
Q9JLW8
resolver
uniprot_sec
Q9JLW9
resolver
uniprot_sec
Q9JLX0
resolver
amino_acid_sequence
MAGGDGMLRRLLRLHRTEIAVAIDSAFPLLHALADHDVVPEDKFQETLRLKEKEGCPQAFHALLSWLLTRDSGAILDFWRILFKDYNLERYSRLHSILDGFPKDVDLNQSRKGRKPLAGPKAAVLPPRPPTKRKALEEPRATPPATLASKSVSSPGSHLKTKPPKKPDGNLESQHLPLGNGIQTMAASVQRAVTVASGDVPGTRGAVEGILIQQVFESGRSKKCIQVGGEFYTPNKFEDPSGNLKNKARSGSSLKPVVRAKGAQVTIPGRDEQKVGQQCGVPPLPSLPSEPQVNQKNEDECAVCHDGGELICCDGCPRAFHLACLSPPLQEIPSGLWRCSCCLQGRVQQNLSQPEVSRPPELPAETPILVGLRSASEKTRGPSRELKASSDAAVTYVNLLAPHPAAPLLEPSALCPLLSAGNEGRPGPAPSARCSVCGDGTEVLRCAHCAAAFHWRCHFPTAAARPGTNLRCKSCSADSTPTPGTPGEAVPTSGPRPAPGLAKVGDDSASHDPVLHRDDLESLLNEHSFDGILQWAIQSMSRPLAETPPFSS
uniprot
proteins
function
FUNCTION: Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (Probable). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (By similarity). Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program (PubMed:19015306). Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression (PubMed:21300913). Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes (PubMed:19923453). In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection (PubMed:26070482). In secondary lymphoid organs, induces functional inactivation of CD4(+) T-cells. Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (PubMed:23993652). {ECO:0000250|UniProtKB:O43918, ECO:0000269|PubMed:19015306, ECO:0000269|PubMed:19923453, ECO:0000269|PubMed:21300913, ECO:0000269|PubMed:23993652, ECO:0000269|PubMed:26070482, ECO:0000305|PubMed:19302042}.
uniprot
proteins
mass_dalton
59042
uniprot
proteins
mutagenesis
MUTAGEN 299; /note="D->A: Abolishes interaction with histone H3."; /evidence="ECO:0000269|PubMed:18840680"; MUTAGEN 303; /note="V->M: No effect on interaction with histone H3."; /evidence="ECO:0000269|PubMed:18840680"; MUTAGEN 312; /note="C->W: Abolishes interaction with histone H3."; /evidence="ECO:0000269|PubMed:18840680"; MUTAGEN 313; /note="C->Y: Abolishes interaction with histone H3."; /evidence="ECO:0000269|PubMed:18840680"; MUTAGEN 328; /note="P->L: Reduces interaction with histone H3."; /evidence="ECO:0000269|PubMed:18840680
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:11533054}.
uniprot
proteins
pubmed
10022980
uniprot
proteins
pubmed
10049587
uniprot
proteins
pubmed
10049735
uniprot
proteins
pubmed
10550218
uniprot
proteins
pubmed
10593569
uniprot
proteins
pubmed
11156688
uniprot
proteins
pubmed
11533054
uniprot
proteins
pubmed
18840680
uniprot
proteins
pubmed
19015306
uniprot
proteins
pubmed
19302042
uniprot
proteins
pubmed
19923453
uniprot
proteins
pubmed
21300913
uniprot
proteins
pubmed
23993652
uniprot
proteins
pubmed
26070482
uniprot
proteins
sequence_length
552
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00185, ECO:0000255|PROSITE-ProRule:PRU00747, ECO:0000269|PubMed:11156688, ECO:0000269|PubMed:19015306, ECO:0000269|PubMed:26070482}. Cytoplasm {ECO:0000269|PubMed:11156688}. Note=Predominantly nuclear but also cytoplasmic. Found in nuclear body-like structures (dots) and in a filamentous vimentin-like pattern. {ECO:0000250|UniProtKB:O43918, ECO:0000269|PubMed:19015306}.
uniprot
proteins