CIAPIN1
entrez
57019
canonical
uniprot
Q6FI81
canonical
ensembl
ENSG00000005194
resolver
ensp
ENSP00000377914
resolver
ensp
ENSP00000454480
resolver
ensp
ENSP00000456114
resolver
ensp
ENSP00000457042
resolver
enst
ENST00000568940
resolver
enst
ENST00000569370
resolver
genesymbol
CIAPIN1
resolver
hgnc
HGNC:28050
resolver
uniprot
A8K8B6
resolver
uniprot
H3BT65
resolver
uniprot
O75206
resolver
uniprot
O75207
resolver
uniprot
Q9H0W1
resolver
uniprot
Q9P1L7
resolver
uniprot_entry
CPIN1_HUMAN
resolver
uniprot_entry
H3BT65_HUMAN
resolver
uniprot_sec
A8K8B6
resolver
uniprot_sec
O75206
resolver
uniprot_sec
O75207
resolver
uniprot_sec
Q9H0W1
resolver
uniprot_sec
Q9P1L7
resolver
amino_acid_sequence
MADFGISAGQFVAVVWDKSSPVEALKGLVDKLQALTGNEGRVSVENIKQLLQSAHKESSFDIILSGLVPGSTTLHSAEILAEIARILRPGGCLFLKEPVETAVDNNSKVKTASKLCSALTLSGLVEVKELQREPLTPEEVQSVREHLGHESDNLLFVQITGKKPNFEVGSSRQLKLSITKKSSPSVKPAVDPAAAKLWTLSANDMEDDSMDLIDSDELLDPEDLKKPDPASLRAASCGEGKKRKACKNCTCGLAEELEKEKSREQMSSQPKSACGNCYLGDAFRCASCPYLGMPAFKPGEKVLLSDSNLHDA
uniprot
proteins
function
FUNCTION: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}.
uniprot
proteins
mass_dalton
33582
uniprot
proteins
protein_family
Anamorsin family
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11483580
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14970183
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16957168
uniprot
proteins
pubmed
17935775
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21700214
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23596212
uniprot
proteins
pubmed
23989406
uniprot
proteins
pubmed
24123282
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26613676
uniprot
proteins
pubmed
27519415
uniprot
proteins
pubmed
27672211
uniprot
proteins
pubmed
29848660
uniprot
proteins
sequence_length
312
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:16957168, ECO:0000269|PubMed:29848660}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:16957168}. Mitochondrion intermembrane space {ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:21700214}.
uniprot
proteins