RIOK2
entrez
55781
canonical
uniprot
Q9BVS4
canonical
ensembl
ENSG00000058729
resolver
ensp
ENSP00000283109
resolver
ensp
ENSP00000420932
resolver
genesymbol
RIOK2
resolver
genesymbol_syn
RIO2
resolver
hgnc
HGNC:18999
resolver
uniprot
D6RDI3
resolver
uniprot
Q9NUT0
resolver
uniprot_entry
RIOK2_HUMAN
resolver
uniprot_sec
D6RDI3
resolver
uniprot_sec
Q9NUT0
resolver
amino_acid_sequence
MGKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLKHGGCNKVLRELVKHKLIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQFALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLDVEVSASGYTKEMQADDELLHPLGPDDKNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLEESEGCYCRSSGDPEQIKEDSLSEESADARSFEMTEFNQALEEIKGQVVENNSVTEFSEEKNRTENYNRQDGQRVQGGVPAGSDEYEDECPHLIALSSLNREFRPFRDEENVGAMNQYRTRTLSITSSGSAVSCSTIPPELVKQKVKRQLTKQQKSAVRRRLQKGEANIFTKQRRENMQNIKSSLEAASFWGE
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}.
uniprot
proteins
mass_dalton
63283
uniprot
proteins
mutagenesis
MUTAGEN 123; /note="K->A: Abolishes autophosphorylation; impairs release of pre-40S trans-acting factors and rRNA processing; when associated with A-246."; /evidence="ECO:0000269|PubMed:19564402"; MUTAGEN 246; /note="D->A: Abolishes autophosphorylation; impairs release of pre-40S trans-acting factors and rRNA processing; when associated with A-123."; /evidence="ECO:0000269|PubMed:19564402"; MUTAGEN 335; /note="S->A: Does not affect autophosphorylation activity; when associated with A-380 and A-548. Does not affect the timing of metaphase-anaphase transition; when associated with A-380 and A-548."; /evidence="ECO:0000269|PubMed:21880710"; MUTAGEN 335; /note="S->D: Increases time spent in metaphase; when associated with D-380 and D-548."; /evidence="ECO:0000269|PubMed:21880710"; MUTAGEN 380; /note="S->A: Does not affect autophosphorylation activity; when associated with A-335 and A-548. Does not affect the timing of metaphase-anaphase transition; when associated with A-335 and A-548."; /evidence="ECO:0000269|PubMed:21880710"; MUTAGEN 380; /note="S->D: Increases time spent in metaphase; when associated with D-335 and D-548."; /evidence="ECO:0000269|PubMed:21880710"; MUTAGEN 400; /note="L->A: Nuclear relocalization; when associated with A-403."; /evidence="ECO:0000269|PubMed:19564402"; MUTAGEN 403; /note="I->A: Nuclear relocalization; when associated with A-400."; /evidence="ECO:0000269|PubMed:19564402"; MUTAGEN 548; /note="S->A: Does not affect autophosphorylation activity; when associated with A-335 and A-380. Does not affect the timing of metaphase-anaphase transition; when associated with A-335 and A-380."; /evidence="ECO:0000269|PubMed:21880710"; MUTAGEN 548; /note="S->D: Increases time spent in metaphase; when associated with D-335 and D-380."; /evidence="ECO:0000269|PubMed:21880710
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated (in vitro) (PubMed:19564402, PubMed:21880710). Phosphorylation at Ser-335, Ser-380, Ser-548 by PLK1 affects the timing of the metaphase-anaphase transition (PubMed:21880710). {ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
RIO-type Ser/Thr kinase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16037817
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19564402
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21081503
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21880710
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
552
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402}. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. {ECO:0000269|PubMed:19564402}.
uniprot
proteins