Il1rl1
entrez
17082
canonical
uniprot
P14719
canonical
ensembl
ENSMUSG00000026069
resolver
ensp
ENSMUSP00000054914
resolver
ensp
ENSMUSP00000095379
resolver
ensp
ENSMUSP00000133784
resolver
ensp
ENSMUSP00000134351
resolver
genesymbol
Il1rl1
resolver
genesymbol_syn
Ly84
resolver
genesymbol_syn
St2
resolver
genesymbol_syn
Ste2
resolver
uniprot
Q05208
resolver
uniprot
Q5D095
resolver
uniprot_entry
ILRL1_MOUSE
resolver
uniprot_entry
Q5D095_MOUSE
resolver
uniprot_sec
Q05208
resolver
amino_acid_sequence
MIDRQRMGLWALAILTLPMYLTVTEGSKSSWGLENEALIVRCPQRGRSTYPVEWYYSDTNESIPTQKRNRIFVSRDRLKFLPARVEDSGIYACVIRSPNLNKTGYLNVTIHKKPPSCNIPDYLMYSTVRGSDKNFKITCPTIDLYNWTAPVQWFKNCKALQEPRFRAHRSYLFIDNVTHDDEGDYTCQFTHAENGTNYIVTATRSFTVEEKGFSMFPVITNPPYNHTMEVEIGKPASIACSACFGKGSHFLADVLWQINKTVVGNFGEARIQEEEGRNESSSNDMDCLTSVLRITGVTEKDLSLEYDCLALNLHGMIRHTIRLRRKQPIDHRSIYYIVAGCSLLLMFINVLVIVLKVFWIEVALFWRDIVTPYKTRNDGKLYDAYIIYPRVFRGSAAGTHSVEYFVHHTLPDVLENKCGYKLCIYGRDLLPGQDAATVVESSIQNSRRQVFVLAPHMMHSKEFAYEQEIALHSALIQNNSKVILIEMEPLGEASRLQVGDLQDSLQHLVKIQGTIKWREDHVADKQSLSSKFWKHVRYQMPVPERASKTASVAAPLSGKACLDLKHF
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP (PubMed:17675517, PubMed:18450470, PubMed:22660580, PubMed:29045903). Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 (By similarity). Possibly involved in helper T-cell function (By similarity). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (PubMed:34644537). {ECO:0000250|UniProtKB:Q01638, ECO:0000269|PubMed:17675517, ECO:0000269|PubMed:18450470, ECO:0000269|PubMed:29045903, ECO:0000269|PubMed:34644537}.; FUNCTION: [Isoform B]: Inhibits IL-33 signaling. {ECO:0000269|PubMed:18450470}.
uniprot
proteins
mass_dalton
64801
uniprot
proteins
mutagenesis
MUTAGEN 326; /note="K->R: Complete loss of FBXL19-mediated polyubiquitination."; /evidence="ECO:0000269|PubMed:22660580"; MUTAGEN 442; /note="S->A: Complete loss of phosphorylation by GSK3B."; /evidence="ECO:0000269|PubMed:22660580
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3B at Ser-442; leading to proteasomal degradation. {ECO:0000269|PubMed:22660580}.; PTM: Ubiquitinated at Lys-326 in a FBXL19-mediated manner; leading to proteasomal degradation (PubMed:22660580). Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response (By similarity). {ECO:0000250|UniProtKB:Q01638, ECO:0000269|PubMed:22660580}.
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
17675517
uniprot
proteins
pubmed
18003919
uniprot
proteins
pubmed
1832015
uniprot
proteins
pubmed
18450470
uniprot
proteins
pubmed
20200353
uniprot
proteins
pubmed
21349253
uniprot
proteins
pubmed
22660580
uniprot
proteins
pubmed
2527364
uniprot
proteins
pubmed
2532153
uniprot
proteins
pubmed
28930661
uniprot
proteins
pubmed
29045903
uniprot
proteins
pubmed
34644537
uniprot
proteins
pubmed
7916701
uniprot
proteins
pubmed
8131748
uniprot
proteins
sequence_length
567
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform B]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 333..355; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins