KMO
entrez
8564
canonical
uniprot
O15229
canonical
ensembl
ENSG00000117009
resolver
ensp
ENSP00000355516
resolver
ensp
ENSP00000355517
resolver
genesymbol
KMO
resolver
hgnc
HGNC:6381
resolver
uniprot
A2A2U8
resolver
uniprot
A2A2U9
resolver
uniprot
A2A2V0
resolver
uniprot
A8K693
resolver
uniprot
Q5SY07
resolver
uniprot
Q5SY08
resolver
uniprot
Q5SY09
resolver
uniprot_entry
A8K693_HUMAN
resolver
uniprot_entry
KMO_HUMAN
resolver
uniprot_sec
A2A2U8
resolver
uniprot_sec
A2A2U9
resolver
uniprot_sec
A2A2V0
resolver
uniprot_sec
Q5SY07
resolver
uniprot_sec
Q5SY08
resolver
uniprot_sec
Q5SY09
resolver
amino_acid_sequence
MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSHRGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLTAAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKKPRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMPFEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCVLLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQISNLISR
uniprot
proteins
ec_number
1.14.13.9
uniprot
proteins
function
FUNCTION: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702, PubMed:29429898). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable). {ECO:0000269|PubMed:23575632, ECO:0000269|PubMed:26752518, ECO:0000269|PubMed:28604669, ECO:0000269|PubMed:29208702, ECO:0000269|PubMed:29429898, ECO:0000305|PubMed:12402501}.
uniprot
proteins
mass_dalton
55810
uniprot
proteins
mutagenesis
MUTAGEN 85; /note="R->A,K: Abolishes kynurenine 3-monooxygenase activity."; /evidence="ECO:0000269|PubMed:29208702"; MUTAGEN 99; /note="Y->A: Abolishes kynurenine 3-monooxygenase activity."; /evidence="ECO:0000269|PubMed:29208702"; MUTAGEN 99; /note="Y->F: Strongly decreases kynurenine 3-monooxygenase activity."; /evidence="ECO:0000269|PubMed:29208702"; MUTAGEN 312..313; /note="FF->AA: Abolishes NADPH oxidase activity."; /evidence="ECO:0000269|PubMed:29429898"; MUTAGEN 312; /note="F->A: Decreases to 30% NADPH oxidase activity."; /evidence="ECO:0000269|PubMed:29429898"; MUTAGEN 313; /note="F->A: Decreases to 50% NADPH oxidase activity."; /evidence="ECO:0000269|PubMed:29429898"; MUTAGEN 363; /note="N->A: Strongly decreases kynurenine 3-monooxygenase activity."; /evidence="ECO:0000269|PubMed:29208702"; MUTAGEN 363; /note="N->D: Abolishes kynurenine 3-monooxygenase activity."; /evidence="ECO:0000269|PubMed:29208702"; MUTAGEN 366; /note="E->A,Q: Strongly decreases kynurenine 3-monooxygenase activity."; /evidence="ECO:0000269|PubMed:29208702"; MUTAGEN 367; /note="M->A: Strongly decreases kynurenine 3-monooxygenase activity."; /evidence="ECO:0000269|PubMed:29208702"; MUTAGEN 367; /note="M->L: Strongly decreases kynurenine 3-monooxygenase activity."; /evidence="ECO:0000269|PubMed:29208702"; MUTAGEN 398; /note="Y->A,F: Abolishes kynurenine 3-monooxygenase activity."; /evidence="ECO:0000269|PubMed:29208702"; MUTAGEN 465; /note="N->A: Not glycosylated. Reduces to 80% kynurenine 3-monooxygenase activity."; /evidence="ECO:0000269|PubMed:29208702
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. {ECO:0000255|HAMAP-Rule:MF_03018}.
uniprot
proteins
protein_family
Aromatic-ring hydroxylase family
uniprot
proteins
protein_family
KMO subfamily
uniprot
proteins
pubmed
10672018
uniprot
proteins
pubmed
12402501
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
23575632
uniprot
proteins
pubmed
26752518
uniprot
proteins
pubmed
28604669
uniprot
proteins
pubmed
29208702
uniprot
proteins
pubmed
29429898
uniprot
proteins
pubmed
9237672
uniprot
proteins
sequence_length
486
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:9237672}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:9237672}.
uniprot
proteins
transmembrane_region
TRANSMEM 385..404; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03018"; TRANSMEM 425..445; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03018
uniprot
proteins