Coro1a
entrez
12721
canonical
uniprot
O89053
canonical
ensembl
ENSMUSG00000030707
resolver
ensp
ENSMUSP00000032949
resolver
ensp
ENSMUSP00000101972
resolver
ensp
ENSMUSP00000253407
resolver
ensp
ENSMUSP00000253412
resolver
enst
ENSMUST00000032949
resolver
enst
ENSMUST00000106364
resolver
genesymbol
Coro1a
resolver
genesymbol_syn
Coro1
resolver
uniprot
Q3U1N0
resolver
uniprot
Q7TMU0
resolver
uniprot
Q9R1Y8
resolver
uniprot
Q9R288
resolver
uniprot_entry
COR1A_MOUSE
resolver
uniprot_entry
Q3U1N0_MOUSE
resolver
uniprot_sec
Q7TMU0
resolver
uniprot_sec
Q9R1Y8
resolver
uniprot_sec
Q9R288
resolver
amino_acid_sequence
MSRQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLVLPLGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEGKILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFSSKESQRGMGYMPKRGLEVNKCEIARFYKLHERKCEPIAMTVPRKSDLFQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYVPPKSRELRVNRGLDSARRRATPEPSGTPSSDTVSRLEEDVRNLNAIVQKLQERLDRLEETVQAK
uniprot
proteins
function
FUNCTION: May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. {ECO:0000269|PubMed:10338208}.
uniprot
proteins
mass_dalton
50989
uniprot
proteins
post_translational_modification
PTM: phosphorylation at Ser-412 by PKC strongly down-regulates the association with actin. {ECO:0000250}.; PTM: Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation. {ECO:0000250}.
uniprot
proteins
protein_family
WD repeat coronin family
uniprot
proteins
pubmed
10338208
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16172398
uniprot
proteins
pubmed
16407068
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23100250
uniprot
proteins
pubmed
9778037
uniprot
proteins
pubmed
9798653
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10338208}. Cytoplasm, cell cortex {ECO:0000269|PubMed:10338208}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:10338208}. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification.
uniprot
proteins