Crtam
entrez
54698
canonical
uniprot
Q149L7
canonical
ensembl
ENSMUSG00000032021
resolver
ensp
ENSMUSP00000137837
resolver
ensp
ENSMUSP00000139826
resolver
genesymbol
Crtam
resolver
uniprot
A0A087WPL6
resolver
uniprot
M0QWH9
resolver
uniprot
Q3TQA9
resolver
uniprot
Q9CVZ9
resolver
uniprot
Q9Z151
resolver
uniprot_entry
CRTAM_MOUSE
resolver
uniprot_sec
A0A087WPL6
resolver
uniprot_sec
M0QWH9
resolver
uniprot_sec
Q3TQA9
resolver
uniprot_sec
Q9CVZ9
resolver
uniprot_sec
Q9Z151
resolver
amino_acid_sequence
MWWGALSLLFWVPVQAAFLKMETVTVEEGQTLTLTCVTSQTKNVSLQWLAPSGFTIFLNQHPALKSSKYQLLHHSATQLSISVSNVTLREEGVYTCLHYGSSVKTKQVRVTVLVTPFQPTVEALVLRRQNGEKSVVLKCSTERSKPPPQITWLLGEGLEIYGELNHEFEADGKICNTSSMLIARAYGKNSTVHCIIQHEGLHGRKLVAPFQFEDLVADQETSDQETSDAPEQSSLSSQALQQPTSTVSMMENSSIPETDKEEKEHATQDPGLSTEASAQHTGLARRKSGILLLTLVSFLIFILFIIVQLFIMKLRKAHVVWKKESEISEQALESYRSRSNNEETSSQENSSQAPQSKRCMNYITRLYSGAKTKKSAQHWKLGGKHSRVPESIV
uniprot
proteins
function
FUNCTION: Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (PubMed:15811952, PubMed:18329370, PubMed:19752223, PubMed:24687959). Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (PubMed:18329370). Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (PubMed:19752223). Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (PubMed:18329370). By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (PubMed:19752223). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (PubMed:24687959). Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (PubMed:24687959). {ECO:0000269|PubMed:15811952, ECO:0000269|PubMed:18329370, ECO:0000269|PubMed:19752223, ECO:0000269|PubMed:24687959}.
uniprot
proteins
mass_dalton
43907
uniprot
proteins
mutagenesis
MUTAGEN 390..393; /note="Missing: In response to TCR stimulation, increases CD4+ T-cell proliferation and impairs IFNG and IL22 production."; /evidence="ECO:0000269|PubMed:18329370
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
10811014
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15781451
uniprot
proteins
pubmed
15811952
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18329370
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19752223
uniprot
proteins
pubmed
24687959
uniprot
proteins
sequence_length
393
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18329370, ECO:0000269|PubMed:19752223, ECO:0000269|PubMed:24687959}; Single-pass type I membrane protein {ECO:0000255}. Note=In a subset of CD4+ T-cells, colocalizes with SCRIB at the immunological synapse during the late phase of T-cell activation. {ECO:0000269|PubMed:18329370}.
uniprot
proteins
transmembrane_region
TRANSMEM 290..310; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins