ANKZF1
entrez
55139
canonical
uniprot
Q9H8Y5
canonical
ensembl
ENSG00000163516
resolver
ensp
ENSP00000321617
resolver
ensp
ENSP00000386337
resolver
ensp
ENSP00000386815
resolver
ensp
ENSP00000576573
resolver
ensp
ENSP00000593214
resolver
ensp
ENSP00000652471
resolver
ensp
ENSP00000652478
resolver
ensp
ENSP00000718571
resolver
enst
ENST00000323348
resolver
enst
ENST00000409849
resolver
enst
ENST00000410034
resolver
enst
ENST00000923155
resolver
genesymbol
ANKZF1
resolver
genesymbol_syn
ZNF744
resolver
hgnc
HGNC:25527
resolver
uniprot
B8ZZS4
resolver
uniprot
Q9NVZ4
resolver
uniprot_entry
ANKZ1_HUMAN
resolver
uniprot_entry
B8ZZS4_HUMAN
resolver
uniprot_sec
Q9NVZ4
resolver
amino_acid_sequence
MSPAPDAAPAPASISLFDLSADAPVFQGLSLVSHAPGEALARAPRTSCSGSGERESPERKLLQGPMDISEKLFCSTCDQTFQNHQEQREHYKLDWHRFNLKQRLKDKPLLSALDFEKQSSTGDLSSISGSEDSDSASEEDLQTLDRERATFEKLSRPPGFYPHRVLFQNAQGQFLYAYRCVLGPHQDPPEEAELLLQNLQSRGPRDCVVLMAAAGHFAGAIFQGREVVTHKTFHRYTVRAKRGTAQGLRDARGGPSHSAGANLRRYNEATLYKDVRDLLAGPSWAKALEEAGTILLRAPRSGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEEDPREAVRLHSPQTHWKTVREERKKPTEEEIRKICRDEKEALGQNEESPKQGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQLGAPTSPIPDSAIVNTRRCWSCGASLQGLTPFHYLDFSFCSTRCLQDHRRQAGRPSS
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation (PubMed:29632312, PubMed:30244831, PubMed:31011209). The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts (PubMed:29632312, PubMed:30244831, PubMed:31011209). ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs (PubMed:31011209). ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1 (PubMed:31011209, PubMed:32075755). Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725). {ECO:0000269|PubMed:28302725, ECO:0000269|PubMed:29632312, ECO:0000269|PubMed:30244831, ECO:0000269|PubMed:31011209, ECO:0000269|PubMed:32075755}.
uniprot
proteins
mass_dalton
80927
uniprot
proteins
mutagenesis
MUTAGEN 246; /note="Q->L: Abolished ability to cleave polypeptidyl-tRNAs."; /evidence="ECO:0000269|PubMed:29632312, ECO:0000269|PubMed:30244831"; MUTAGEN 661..662; /note="AA->LL: Abolishes interaction with VCP."; /evidence="ECO:0000269|PubMed:21896481
uniprot
proteins
protein_family
ANKZF1/VMS1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21896481
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28302725
uniprot
proteins
pubmed
29632312
uniprot
proteins
pubmed
30244831
uniprot
proteins
pubmed
31011209
uniprot
proteins
pubmed
32075755
uniprot
proteins
sequence_length
726
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28302725}. Note=Translocates to the mitochondria upon exposure to hydrogen peroxide. {ECO:0000269|PubMed:28302725}.
uniprot
proteins