Slc16a7
entrez
29735
canonical
uniprot
Q63344
canonical
ensembl
ENSRNOG00000007839
resolver
ensembl
ENSRNOG00055027006
resolver
ensembl
ENSRNOG00060010003
resolver
ensembl
ENSRNOG00065016859
resolver
ensp
ENSRNOP00000054845
resolver
ensp
ENSRNOP00055038270
resolver
ensp
ENSRNOP00060013220
resolver
ensp
ENSRNOP00065022268
resolver
enst
ENSRNOT00000058036
resolver
enst
ENSRNOT00055046632
resolver
enst
ENSRNOT00060016927
resolver
enst
ENSRNOT00065028155
resolver
genesymbol
Slc16a7
resolver
genesymbol_syn
Mct2
resolver
uniprot
Q63649
resolver
uniprot
Q66HS9
resolver
uniprot_entry
MOT2_RAT
resolver
uniprot_sec
Q63649
resolver
uniprot_sec
Q66HS9
resolver
activity_regulation
ACTIVITY REGULATION: Transport activity exhibits steep dependence on substrate concentration. Substrate concentration sensitivity of SLC16A7 arises from the strong inter-subunit cooperativity of the SLC16A7 dimer during transport. Inhibited by AR-C155858. {ECO:0000269|PubMed:20695846}.
uniprot
proteins
amino_acid_sequence
MPSESSVKATAAPPPFPLPPDGGWGWVVVCASFISIGFSYAFPKAVTVFFNDIKDIFKTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCTGMILASFSSSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRKRPLANGFAMAGSPVFLSTLAPFNQFLFNSYGWKGSFLILGAIFLHSCVAGCLMRPVGPSPRAAKSKSKVGSRQDSSTKRLSKVSTAEKINRFLDFGLFTHRGFLIYLSGNVVLFLGMFAPIIFLAPYAKDKGVDDYNSAFLLSVMAFTDMFARPSVGLIANTSLIRPRIQYLFSVAIMFTGICHLLCPLAHSYTALVVYVIFFGIGFGSISSLLFECLMDQVGASRFSSAVGLVTIVECCPVLFGPPLAGKLLDITGQYKYLYIASGIVVLSSGIYLLICNAINYRLLEKERKREKARRKKSASQASKEMEALSRSKQDDVTVKVSNTHNPPSDRDKESSI
uniprot
proteins
function
FUNCTION: Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:10417314, PubMed:20695846). Dimerization is functionally required and both subunits work cooperatively in transporting substrate (By similarity). {ECO:0000250|UniProtKB:O60669, ECO:0000269|PubMed:10417314, ECO:0000269|PubMed:20695846}.
uniprot
proteins
mass_dalton
53043
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
10417314
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15917240
uniprot
proteins
pubmed
20695846
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9182702
uniprot
proteins
pubmed
9482213
uniprot
proteins
sequence_length
489
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15917240, ECO:0000269|PubMed:20695846, ECO:0000269|PubMed:9182702, ECO:0000269|PubMed:9482213}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O60669}. Basolateral cell membrane {ECO:0000250|UniProtKB:P53988}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O60669}. Cytoplasm {ECO:0000250|UniProtKB:O70451}. Note=Requires the ancillary protein, EMB for plasma membrane localization (PubMed:15917240, PubMed:20695846). Colocalizes with BSG in spermatozoa. Detected in the cytoplasm of Sertoli cells (By similarity). {ECO:0000250|UniProtKB:O70451, ECO:0000269|PubMed:15917240, ECO:0000269|PubMed:20695846}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 66..86; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 96..116; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 122..142; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 180..200; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 251..271; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 287..307; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 317..337; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 343..363; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 378..398; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 411..431; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins