Mtarc2
entrez
67247
canonical
uniprot
Q922Q1
canonical
ensembl
ENSMUSG00000073481
resolver
ensp
ENSMUSP00000066715
resolver
ensp
ENSMUSP00000212589
resolver
enst
ENSMUST00000068725
resolver
genesymbol
Mtarc2
resolver
genesymbol_syn
Marc2
resolver
genesymbol_syn
Mg87
resolver
genesymbol_syn
Mosc2
resolver
uniprot_entry
MARC2_MOUSE
resolver
amino_acid_sequence
MGSSSSTALARLGLPGQPRSTWLGVAALGLAAVALGTVAWRRTRPRRRRQLQQVGTVSKVWIYPIKSCKGVSVCETECTDMGLRCGKVRDRFWMVVKEDGHMVTARQEPRLVLVSITLENNYLTLEAPGMEQIVLPIKLPSSNKIHNCRLFGLDIKGRDCGDEVAQWFTNYLKTQAYRLVQFDTSMKGRTTKKLYPSESYLQNYEVAYPDCSPVHLISEASLVDLNTRLKKKVKMEYFRPNIVVSGCEAFEEDTWDELLIGDVEMKRVLSCPRCVLTTVDPDTGIIDRKEPLETLKSYRLCDPSVKSIYQSSPLFGMYFSVEKLGSLRVGDPVYRMVD
uniprot
proteins
ec_number
1.7.-.-
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction. {ECO:0000250|UniProtKB:Q969Z3}.
uniprot
proteins
mass_dalton
38194
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. {ECO:0000250|UniProtKB:Q969Z3}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17768142
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P0C2C3}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0C2C3}. Peroxisome {ECO:0000269|PubMed:17768142}.
uniprot
proteins