Atp2b2
entrez
24215
canonical
uniprot
P11506
canonical
ensembl
ENSRNOG00000030269
resolver
ensembl
ENSRNOG00065028357
resolver
ensp
ENSRNOP00000045983
resolver
ensp
ENSRNOP00000098554
resolver
ensp
ENSRNOP00000098555
resolver
enst
ENSRNOT00000043476
resolver
genesymbol
Atp2b2
resolver
uniprot
D4A8B3
resolver
uniprot
Q63443
resolver
uniprot_entry
AT2B2_RAT
resolver
uniprot_entry
D4A8B3_RAT
resolver
uniprot_sec
Q63443
resolver
activity_regulation
ACTIVITY REGULATION: Up-regulated by calmodulin which increases the affinity of the pump for Ca(2+) ions (By similarity). Regulated by phospholipids such as phosphatidylinositol 4,5-bisphosphate; this interaction is essential for optimal activity (By similarity). {ECO:0000250|UniProtKB:Q01814, ECO:0000250|UniProtKB:Q9R0K7}.
uniprot
proteins
amino_acid_sequence
MGDMTNSDFYSKNQRNESSHGGEFGCSMEELRSLMELRGTEAVVKIKETYGDTESICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGESNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQIKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQLPAADGAAPANAAGSANASLVNGKMQDGSADSSQSKAKQQDGAAAMEMQPLKSAEGGDADDKKKANMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLTECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINAKTLELLVNAIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFVLDLRQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKMPDESFRMYSKGASEIVLKKCCKILSGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLTLIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL
uniprot
proteins
ec_number
7.2.2.10
uniprot
proteins
function
FUNCTION: ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (By similarity). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (By similarity). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (By similarity). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). {ECO:0000250|UniProtKB:Q01814, ECO:0000250|UniProtKB:Q9R0K7}.
uniprot
proteins
mass_dalton
136811
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIB subfamily
uniprot
proteins
pubmed
1315513
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2837461
uniprot
proteins
pubmed
8428948
uniprot
proteins
sequence_length
1243
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q01814}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9R0K7}. Synapse {ECO:0000250|UniProtKB:Q9R0K7}. Apical cell membrane {ECO:0000250|UniProtKB:Q01814}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9R0K7}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q01814}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9R0K7}.
uniprot
proteins
transmembrane_region
TRANSMEM 95..115; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9R0K7"; TRANSMEM 153..173; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9R0K7"; TRANSMEM 391..410; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9R0K7"; TRANSMEM 444..461; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9R0K7"; TRANSMEM 876..895; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9R0K7"; TRANSMEM 906..926; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9R0K7"; TRANSMEM 947..969; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9R0K7"; TRANSMEM 988..1009; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q9R0K7"; TRANSMEM 1029..1050; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q9R0K7"; TRANSMEM 1061..1082; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q9R0K7
uniprot
proteins