Ankzf1
entrez
363255
canonical
uniprot
Q66H85
canonical
ensembl
ENSRNOG00000019052
resolver
ensp
ENSRNOP00000036500
resolver
ensp
ENSRNOP00000111906
resolver
enst
ENSRNOT00000032419
resolver
enst
ENSRNOT00000139430
resolver
genesymbol
Ankzf1
resolver
uniprot
A0A8L2QKJ1
resolver
uniprot
A0ABK0MA19
resolver
uniprot_entry
A0A8L2QKJ1_RAT
resolver
uniprot_entry
A0ABK0MA19_RAT
resolver
uniprot_entry
ANKZ1_RAT
resolver
amino_acid_sequence
MLPAPRAAPVPASVSLLTLNGEAPLVRGLSLVSQAPGEALAWAPRTSCPGENTSSGRKVSPCSLDISDKLFCSACDQVFQNHQEQREHYKLDWHRFNLKQRLKNKPLLSASDFERQSSRGDLSSISGSEDSDSASEEDLLTLDEERAESEKPNRPPGFYPHRVLFRNAQGQFLYAYRCVLGPHQIPPEKAELLLQNLQNGGPRHYVVLMAAAGHFAGAIFQGREVVAHKTFHRYTVRAKRGTAQGLQDAQGRASRSAGANLRRYNEAMLYKDVRDLLAGPTWSKALGEAETILLHAPRSGRSLFFGGQGAPLQRSDFRLWDIPLTTRRPTFGELQRVLHKLTTLQVYDEDPREMVRFHSPETHCKPVREERKRDTEKEKTKVPSDANKALGQDEEPLKQGSESQEEDGSEVELELVELTLGTLDLREFEVLPKRRKKRKKKERSQKQQCGAHGPLLQQPQDEPFSQPTQVVATPLDTLVDEAKAPGQPELWDMLLAACRAGEVEVLKLQLATGPVDPGVMSLLSAPLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVHDSRARPPYTVAADRSTRNEFRRFMEKNLDAYDYSKARVPGPLTQEMEARQATRKKEQKAARRQREQQQRKQREQEEQEQEERRRFAALSDREKRALAAERRLAAQLGAPSPPVPDSAVVNAGRCWSCGVSLQGLIPFHYLDFSFCSTRCLRDHRSQAGRPSS
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation. The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts. ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs. ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1. Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress. {ECO:0000250|UniProtKB:Q9H8Y5}.
uniprot
proteins
mass_dalton
80585
uniprot
proteins
protein_family
ANKZF1/VMS1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
722
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H8Y5}. Note=Translocates to the mitochondria upon exposure to hydrogen peroxide. {ECO:0000250|UniProtKB:Q9H8Y5}.
uniprot
proteins