Kcnmb1
entrez
29747
canonical
uniprot
P97678
canonical
ensembl
ENSRNOG00000005465
resolver
ensembl
ENSRNOG00055002934
resolver
ensembl
ENSRNOG00060002803
resolver
ensembl
ENSRNOG00065009520
resolver
ensp
ENSRNOP00000071161
resolver
ensp
ENSRNOP00000103628
resolver
genesymbol
Kcnmb1
resolver
uniprot
O35337
resolver
uniprot
O88805
resolver
uniprot
Q9ESK7
resolver
uniprot
Q9QWI7
resolver
uniprot_entry
KCMB1_RAT
resolver
uniprot_sec
O35337
resolver
uniprot_sec
O88805
resolver
uniprot_sec
Q9ESK7
resolver
uniprot_sec
Q9QWI7
resolver
amino_acid_sequence
MGKKLVMAQKRGETRALCLGVAMVVCAAITYYILGTTVLPLYQKSVWTQESTCHLVETNIKDQEELEGRKVPQYPCLWVNVSAVGRWAMLYHTEDTRDQNQQCSYIPRNLDNYQTALVDVKKVRANFYKHHNFYCFSAPQVNETSVVYQRLYGPQILLFSFFWPTFLLTGGLLIIAMVKLNRSLSVLAAQK
uniprot
proteins
function
FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
21909
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
KCNMB (TC 8.A.14.1) family
uniprot
proteins
protein_family
KCNMB1 subfamily
uniprot
proteins
pubmed
9105668
uniprot
proteins
pubmed
9888999
uniprot
proteins
sequence_length
191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 156..176; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins