Sox10
entrez
20665
canonical
uniprot
Q04888
canonical
ensembl
ENSMUSG00000033006
resolver
ensp
ENSMUSP00000039466
resolver
ensp
ENSMUSP00000155574
resolver
enst
ENSMUST00000040019
resolver
enst
ENSMUST00000230532
resolver
genesymbol
Sox10
resolver
genesymbol_syn
Sox-10
resolver
genesymbol_syn
Sox21
resolver
uniprot
O08518
resolver
uniprot
O09141
resolver
uniprot
O54856
resolver
uniprot
P70416
resolver
uniprot_entry
SOX10_MOUSE
resolver
uniprot_sec
O08518
resolver
uniprot_sec
O09141
resolver
uniprot_sec
O54856
resolver
uniprot_sec
P70416
resolver
amino_acid_sequence
MAEEQDLSEVELSPVGSEEPRCLSPGSAPSLGPDGGGGGSGLRASPGPGELGKVKKEQQDGEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKAAQGEAECPGGEAEQGGAAAIQAHYKSAHLDHRHPEEGSPMSDGNPEHPSGQSHGPPTPPTTPKTELQSGKADPKRDGRSLGEGGKPHIDFGNVDIGEISHEVMSNMETFDVTELDQYLPPNGHPGHVGSYSAAGYGLGSALAVASGHSAWISKPPGVALPTVSPPGVDAKAQVKTETTGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQFDYSDHQPSGPYYGHAGQASGLYSAFSYMGPSQRPLYTAISDPSPSGPQSHSPTHWEQPVYTTLSRP
uniprot
proteins
function
FUNCTION: Transcription factor that plays a central role in developing and mature glia (PubMed:24204311, PubMed:27532821). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:24204311, PubMed:27532821). Once induced, MYRF cooperates with SOX10 to implement the myelination program (PubMed:24204311). Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). Transcriptional activator of MBP, via binding to the gene promoter (By similarity). {ECO:0000250|UniProtKB:O55170, ECO:0000250|UniProtKB:P56693, ECO:0000269|PubMed:24204311, ECO:0000269|PubMed:27532821}.
uniprot
proteins
mass_dalton
49949
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19304657
uniprot
proteins
pubmed
24204311
uniprot
proteins
pubmed
26525805
uniprot
proteins
pubmed
27532821
uniprot
proteins
pubmed
8441686
uniprot
proteins
pubmed
8921394
uniprot
proteins
pubmed
9027483
uniprot
proteins
pubmed
9425902
uniprot
proteins
pubmed
9560246
uniprot
proteins
pubmed
9760192
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19304657}. Nucleus {ECO:0000269|PubMed:19304657, ECO:0000269|PubMed:9560246}. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:19304657}.
uniprot
proteins