Cenpn
entrez
72155
canonical
uniprot
Q9CZW2
canonical
ensembl
ENSMUSG00000031756
resolver
ensp
ENSMUSP00000034205
resolver
ensp
ENSMUSP00000250074
resolver
genesymbol
Cenpn
resolver
uniprot
Q6PE73
resolver
uniprot
Q8R2W7
resolver
uniprot_entry
CENPN_MOUSE
resolver
uniprot_sec
Q6PE73
resolver
uniprot_sec
Q8R2W7
resolver
amino_acid_sequence
MKENVAEFLRRTILKIPLSEMKSILEAWDFLSEDQLQTINLKQRKDYLAQEVILLCEDKRASLDDVVLLDIVYTQFHRHQKLWNVFQMSKEPGEDVDLFDMEQFQSSFKRILQRALKNVTVSFRVYEKDSVWIRVAWGTQYSQPNQYKPTFVVYYPQTPYAFISSCHLKNTVPLLHQALKVASKHHQIVHLDLRSRHLDSLKAIVFREYNQTCENYSSTTSLQEASLSMCLDSKITHENTEEKVRVHRVTQETFGTYPQPQLEFAQYKLETKFKSNIGGGLLADRKEPFRCLVKFSSPHLLEALKSLAPAGIADAPLSPLLTCIPSKKMNYFKIRDK
uniprot
proteins
function
FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000250|UniProtKB:Q96H22}.
uniprot
proteins
mass_dalton
39240
uniprot
proteins
protein_family
CENP-N/CHL4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes exclusively in the kinetochore domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis. {ECO:0000250}.
uniprot
proteins