Atp10a
entrez
11982
canonical
uniprot
O54827
canonical
ensembl
ENSMUSG00000025324
resolver
ensp
ENSMUSP00000129811
resolver
enst
ENSMUST00000168747
resolver
genesymbol
Atp10a
resolver
genesymbol_syn
Atpc5
resolver
genesymbol_syn
Pfatp
resolver
genesymbol_syn
mKIAA0566
resolver
uniprot
Q3V1Y7
resolver
uniprot
Q6A046
resolver
uniprot
Q8R3B8
resolver
uniprot_entry
AT10A_MOUSE
resolver
uniprot_entry
Q3V1Y7_MOUSE
resolver
uniprot_entry
Q6A046_MOUSE
resolver
uniprot_sec
Q8R3B8
resolver
amino_acid_sequence
MERELPAAEESASSGWRRPRRRRWEGRTRTVRSNLLPPLGTEDSTIGAPKGERLLMRGCIQHLADNRLKTTKYTLLSFLPKNLFEQFHRLANVYFVFIALLNFVPAVNAFQPGLALAPVLFILAVTAIKDLWEDYSRHRSDHEINHLGCLVFSREEKKYVNRYWKEIRVGDFVRLCCNEIIPADILLLSSSDPDGLCHIETANLDGETNLKRRQVVRGFSELVSEFNPLTFTSVIECEKPNNDLSRFRGYIMHSNGEKAGLHKENLLLRGCTIRNTEAVAGIVIYAGHETKALLNNSGPRYKRSQLERQMNCDVLWCVLLLVCISLFSAVGHGLWVRRYQEKKALFDVPESDGSSLSPATAAVYSFFTMIIVLQVLIPISLYVSIEIVKVCQVYFINQDIELYDEETDSQLQCRALNITEDLGQIKYIFSDKTGTLTENKMVFRRCTVSGIEYSHDANAQRLARYQEADSEEEEVVSKVGTISHRGSTGSHQSIWMTHKTQSIKSHRRTGSRAEAKRASMLSKHTAFSSPMEKDITPDPKLLEKVSECDRFLAIARHQEHPLAHLSPELSDVFDFFIALTICNTVVVTSPDQPRQKVRVRFELKSPVKTIEDFLRRFTPSRLASGCSSIGNLSTSKSSHKSGSAFLPSLSQDSMLLGLEEKLGQTAPSIASNGYASQAGQEESWASECTTDQKCPGEQREQQEGELRYEAESPDEAALVYAARAYNCALVDRLHDQVSVELPHLGRLTFELLHTLGFDSIRKRMSVVIRHPLTDEINVYTKGADSVVMDLLLPCSSDDARGRHQKKIRSKTQNYLNLYAVEGLRTLCIAKRVLSKEEYACWLQSHIEAEASVESREELLFQSAVRLETNLHLLGATGIEDRLQEGVPETIAKLRQAGLQIWVLTGDKQETAINIAYACKLLDHGEEVITLNADSQEACAALLDQCLSYVQSRNPRSTLQNSESNLSVGFSFNPVSTSTDASPSPSLVIDGRSLAYALEKSLEDKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRSKLKAMTLAIGDGANDVSMIQVADVGVGISGQEGMQAVMASDFAVPRFRYLERLLIVHGHWCYSRLANMVLYFFYKNTMFVGLLFWFQFYCGFSASAMIDQWYLIFFNLLFSSLPQLVTGVLDKDVPADMLLREPQLYKSGQNMEEYRPRAFWLNMVDAAFQSLVCFFIPYLAYYDSDVDVFTWGTPVTAIALFTFLLHLGIETKTWTWLNWLACGFSTFLFFSVALIYNTSCATCYPPSNPYWTMQTLLGDPLFYLTCLIAPIAALLPRLFFKALQGSLFPTQLQLGRQLAKKPLNKFSDPKETFAQGQPPGHSETELSERKTMGPFETLPRDCASQASQFTQQLTCSPEASGEPSAVDTNMPLRENTLLEGLGSQASGSSMPRGAISEVCPGDSKRQSTSASQTARLSSLFHLPSFGSLNWISSLSLASGLGSVLQLSGSSLQMDKQDGEFLSNPPQPEQDLHSFQGQVTGYL
uniprot
proteins
ec_number
7.6.2.1
uniprot
proteins
function
FUNCTION: Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking. Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix. Has low flippase activity toward glucosylceramide (GlcCer). {ECO:0000250|UniProtKB:O60312}.
uniprot
proteins
mass_dalton
168788
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated at the conserved aspartate of the P-type ATPase signature sequence. {ECO:0000250|UniProtKB:O94823}.
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IV subfamily
uniprot
proteins
pubmed
11015572
uniprot
proteins
pubmed
11074018
uniprot
proteins
pubmed
12105293
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9548971
uniprot
proteins
sequence_length
1508
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O60312}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O60312}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O60312}. Note=Exit from the endoplasmic reticulum requires the presence of CDC50A, but not that of CDC50B. {ECO:0000250|UniProtKB:O60312}.
uniprot
proteins
transmembrane_region
TRANSMEM 80..101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 108..129; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 314..335; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 367..388; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1102..1122; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1135..1154; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1185..1206; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1214..1236; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1243..1263; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1282..1306; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins