Arl2
entrez
65142
canonical
uniprot
O08697
canonical
ensembl
ENSRNOG00000021010
resolver
ensp
ENSRNOP00000028525
resolver
ensp
ENSRNOP00000076049
resolver
enst
ENSRNOT00000028525
resolver
genesymbol
Arl2
resolver
genesymbol_syn
Arl184
resolver
uniprot
G3V8V0
resolver
uniprot_entry
ARL2_RAT
resolver
uniprot_entry
G3V8V0_RAT
resolver
amino_acid_sequence
MGLLTILKKMKQKERDVRLLMLGLDNAGKTTILKKFNGEDVDTISPTLGFNIKTLEHRGFKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERLAGATLLIFANKQDLPGALSCNAIQEALELDSIRSHHWRIQGCSAVTGEDLLPGIDWLLDDISSRVFTAD
uniprot
proteins
function
FUNCTION: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
20836
uniprot
proteins
post_translational_modification
PTM: Not N-myristoylated.
uniprot
proteins
protein_family
Arf family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11809823
uniprot
proteins
pubmed
12527357
uniprot
proteins
pubmed
12912990
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9208929
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000269|PubMed:11809823}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11809823}. Nucleus {ECO:0000269|PubMed:11809823}. Cytoplasm {ECO:0000269|PubMed:11809823}. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). {ECO:0000250}.
uniprot
proteins