Inhbe
entrez
16326
canonical
uniprot
O08717
canonical
ensembl
ENSMUSG00000047492
resolver
ensp
ENSMUSP00000053977
resolver
enst
ENSMUST00000059718
resolver
genesymbol
Inhbe
resolver
uniprot
Q91XH3
resolver
uniprot_entry
INHBE_MOUSE
resolver
uniprot_sec
Q91XH3
resolver
amino_acid_sequence
MKLPKAQLWLILLWALVWVQSTRSACPSCGGPTLAPQGERALVLELAKQQILEGLHLTSRPRITRPLPQAALTRALRRLQPKSMVPGNREKVISFATIIDKSTSTYRSMLTFQLSPLWSHHLYHARLWLHVPPSFPGTLYLRIFRCGTTRCRGFRTFLAEHQTTSSGWHALTLPSSGLRSEDSGVVKLQLEFRPLDLNSTAAGLPRLLLDTAGQQRPFLELKIRANEPGAGRARRRTPTCEPETPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPAGSSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS
uniprot
proteins
function
FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.; FUNCTION: Activin E is a homodimer of INHBE secreted by the liver that plays a crucial role in regulating metabolic homeostasis particularly in lipid metabolism and energy homeostasis. Plays a central role in the regulation of adipose tissue lipolysis by preventing the influx of fatty acids from adipose tissue into the liver (PubMed:39948368). Mechanistically, signals via ACVR1C to activate SMAD2/3 signaling, suppressing PPARG target genes in adipose tissue, thereby reducing liver lipid content and improving glycemic control (PubMed:37523551, PubMed:39948368). Induces beige adipocyte formation and thermogenesis in response to cold exposure (Ref.5). {ECO:0000269|PubMed:37523551, ECO:0000269|PubMed:39948368, ECO:0000269|Ref.5}.
uniprot
proteins
mass_dalton
39002
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
37523551
uniprot
proteins
pubmed
39948368
uniprot
proteins
pubmed
8941337
uniprot
proteins
pubmed
9070865
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins