Cngb1
entrez
333329
canonical
uniprot
E1AZ71
canonical
ensembl
ENSMUSG00000031789
resolver
ensp
ENSMUSP00000090956
resolver
ensp
ENSMUSP00000112437
resolver
ensp
ENSMUSP00000113750
resolver
ensp
ENSMUSP00000113827
resolver
enst
ENSMUST00000093268
resolver
enst
ENSMUST00000119870
resolver
enst
ENSMUST00000120044
resolver
enst
ENSMUST00000121162
resolver
genesymbol
Cngb1
resolver
genesymbol_syn
BC016201
resolver
uniprot
E9PXX0
resolver
uniprot
F7BZZ5
resolver
uniprot
Q80VQ4
resolver
uniprot
Q80XL8
resolver
uniprot
Q91WA8
resolver
uniprot_entry
CNGB1_MOUSE
resolver
uniprot_entry
E9PXX0_MOUSE
resolver
uniprot_entry
F7BZZ5_MOUSE
resolver
uniprot_entry
Q80VQ4_MOUSE
resolver
uniprot_entry
Q80XL8_MOUSE
resolver
uniprot_entry
Q91WA8_MOUSE
resolver
amino_acid_sequence
MLGWVQRVLPQPPGTPQKTVETAGPQPETESKPEANPQPEPEPQQEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPVPEEAPPEVQALPPEEPMEGEGEAEAGPSLQETQVADPAQPTSQAQVAVAKVNRPSSWMLSWFWRGMQKVVPQPVCSNGGQNLAAGERDPDQGGAQIPEPCGTGDPGSAEASGTQDTEPSLWLLRWLEQNLEKVLPQPPPPSLAWKVEPEAAVLDPDPPGTPMQMEPTESPSQPNPGPLEPEEEPAAEPQPGFQSSSLPPPGDPVRLIEWLLHRLEMALPQPVLHGKAAEQEPGCPGMCDVQTISILPVEQVEHDLVLEEVDSCWEDAQQEDGASPQETEVAPAHEEESEAIVEIPRELTKIQEEREDEQEEDEEEKEEEKKKGEEEKEKEEEEKEKEKEKEEEKEEEEKEEEEEEEKEEEEEEKEEEEKEEEEKEEEEEEEEEEEEPIVLLDSCLVVQADVDECQLERTPSELASIQELPEEKEEKEEEKEEEKEEEEEKKEEEVEKKEEGEATNSTVPATKEHPELQVEDTDADSGPLIPEETLPPPERPPPSPVKSDTLTVPGAAAAGHRKKLPSQDDEAEELKALSPAESPVVAWSDPTTPQEADGQDRAASTASQNSAIINDRLQELVKMFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPDPAQKPAEAEVAEEEHYCDMLCCKFKRRPLKMYRFPQSIDPLTNLMYILWLFFVVLAWNWNCWLIPVRWAFPYQRADNIHFWLLMDYLCDFIYLLDITVFQMRLQFVKGGDIITDKKEMRNNYLKSRRFKMDLLCLLPLDFLYLKLGINPLLRLPRCLKYMAFFEFNNRLEAILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAFQGIGSTHWVYDGVGNSYIRCYYWAVKTLITIGGLPDPQTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPRSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYSIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKAVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRNNNKPKEEKSVLILPPRAGTPKLFNAALAAAGKMGPRGAKGGKLAHLRARLKELAALEAAARQQQLLEQAKSSQEAGGEEGSGATDQPAPQEPPEPKDPPKPPGPPEPSAQSSPPPASAKPEESTGEAAGPPEPSVRIRVSPGPDPGEQTLSVEVLEEKKEGAE
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade (By similarity) (PubMed:15634774, PubMed:22802073). Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants (By similarity) (PubMed:16980309). Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels (By similarity). {ECO:0000250|UniProtKB:A0A8I5ZN27, ECO:0000250|UniProtKB:Q28181, ECO:0000250|UniProtKB:Q9NQW8, ECO:0000269|PubMed:15634774, ECO:0000269|PubMed:16980309, ECO:0000269|PubMed:22802073}.
uniprot
proteins
mass_dalton
148716
uniprot
proteins
protein_family
CNGB1 subfamily
uniprot
proteins
protein_family
Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
uniprot
proteins
pubmed
11764791
uniprot
proteins
pubmed
15634774
uniprot
proteins
pubmed
16980309
uniprot
proteins
pubmed
19299621
uniprot
proteins
pubmed
19339551
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22802073
uniprot
proteins
sequence_length
1325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000269|PubMed:15634774, ECO:0000269|PubMed:19299621}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000269|PubMed:16980309}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in rod outer segment membranes. {ECO:0000269|PubMed:15634774}.
uniprot
proteins
transmembrane_region
TRANSMEM 733..754; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:Q14028"; TRANSMEM 764..785; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:Q14028"; TRANSMEM 801..820; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:Q14028"; TRANSMEM 837..849; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:Q14028"; TRANSMEM 862..884; /note="Helical; Name=S5"; /evidence="ECO:0000250|UniProtKB:Q14028"; TRANSMEM 908..934; /note="Helical; Name=P-helix"; /evidence="ECO:0000250|UniProtKB:Q14028"; TRANSMEM 935..960; /note="Helical; Name=S6"; /evidence="ECO:0000250|UniProtKB:Q14028
uniprot
proteins