Ints14
entrez
69882
canonical
uniprot
Q8R3P6
canonical
ensembl
ENSMUSG00000034263
resolver
ensp
ENSMUSP00000049284
resolver
ensp
ENSMUSP00000127420
resolver
ensp
ENSMUSP00000308251
resolver
ensp
ENSMUSP00000308259
resolver
ensp
ENSMUSP00000308260
resolver
genesymbol
Ints14
resolver
genesymbol_syn
Vwa9
resolver
uniprot
Q3THM0
resolver
uniprot
Q3V323
resolver
uniprot
Q3V3E8
resolver
uniprot
Q8C072
resolver
uniprot_entry
INT14_MOUSE
resolver
uniprot_sec
Q3THM0
resolver
uniprot_sec
Q3V323
resolver
uniprot_sec
Q3V3E8
resolver
uniprot_sec
Q8C072
resolver
amino_acid_sequence
MPTVVVMDVSLSMTRPVSVEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATQNQRSESNRFPLPFPFPSKLYVMCMANLEELQSTDSLECLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTADVQVFPRPEPFVIDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGAGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVALVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPDTAHPDAAFQLTHAAQQLKLASTEYAIYDHNITPLHTDFSGSSTERM
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS14 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters. {ECO:0000250|UniProtKB:Q96SY0}.
uniprot
proteins
mass_dalton
57237
uniprot
proteins
protein_family
Integrator subunit 14 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VPY0}.
uniprot
proteins