PTRH1
entrez
138428
canonical
uniprot
Q86Y79
canonical
ensembl
ENSG00000187024
resolver
ensp
ENSP00000418219
resolver
ensp
ENSP00000418661
resolver
ensp
ENSP00000439469
resolver
ensp
ENSP00000485347
resolver
ensp
ENSP00000485479
resolver
ensp
ENSP00000693217
resolver
ensp
ENSP00000693219
resolver
enst
ENST00000419060
resolver
enst
ENST00000423807
resolver
enst
ENST00000543175
resolver
genesymbol
PTRH1
resolver
genesymbol_syn
C9orf115
resolver
hgnc
HGNC:27039
resolver
uniprot
C9J7Z1
resolver
uniprot_entry
C9J7Z1_HUMAN
resolver
uniprot_entry
PTH_HUMAN
resolver
amino_acid_sequence
MRPGGFLGAGQRLSRAMSRCVLEPRPPGKRWMVAGLGNPGLPGTRHSVGMAVLGQLARRLGVAESWTRDRHCAADLALAPLGDAQLVLLRPRRLMNANGRSVARAAELFGLTAEEVYLVHDELDKPLGRLALKLGGSARGHNGVRSCISCLNSNAMPRLRVGIGRPAHPEAVQAHVLGCFSPAEQELLPLLLDRATDLILDHIRERSQGPSLGP
uniprot
proteins
ec_number
3.1.1.29
uniprot
proteins
function
FUNCTION: Peptidyl-tRNA hydrolase that cleaves nascent chains-tRNAs that are not stably fixed in the P-site of 60S ribosome-nascent chain complexes (PubMed:30244831). Acts downstream of the ribosome-associated quality control (RQC) pathway to release non-ubiquitinated nascent chains from 60S and 80S ribosome-nascent chain complexes (PubMed:30244831). Does not act on ubiquitinated nascent chains, which are cleaved by ANKZF1 for degradation (PubMed:30244831). {ECO:0000269|PubMed:30244831}.
uniprot
proteins
mass_dalton
22937
uniprot
proteins
mutagenesis
MUTAGEN 46; /note="H->N: Abolished peptidyl-tRNA activity."; /evidence="ECO:0000269|PubMed:30244831"; MUTAGEN 121; /note="D->A: Abolished peptidyl-tRNA activity."; /evidence="ECO:0000269|PubMed:30244831
uniprot
proteins
protein_family
PTH family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
30244831
uniprot
proteins
sequence_length
214
uniprot
proteins