MORF4L1
entrez
10933
canonical
uniprot
Q9UBU8
canonical
ensembl
ENSG00000185787
resolver
ensp
ENSP00000331310
resolver
ensp
ENSP00000408880
resolver
ensp
ENSP00000452717
resolver
ensp
ENSP00000452808
resolver
genesymbol
MORF4L1
resolver
genesymbol_syn
MRG15
resolver
hgnc
HGNC:16989
resolver
uniprot
B4DKN6
resolver
uniprot
B7Z6R1
resolver
uniprot
D3DW88
resolver
uniprot
O95899
resolver
uniprot
Q5QTS1
resolver
uniprot
Q6NVX8
resolver
uniprot
Q86YT7
resolver
uniprot
Q9HBP6
resolver
uniprot
Q9NSW5
resolver
uniprot_entry
MO4L1_HUMAN
resolver
uniprot_sec
B4DKN6
resolver
uniprot_sec
B7Z6R1
resolver
uniprot_sec
D3DW88
resolver
uniprot_sec
O95899
resolver
uniprot_sec
Q5QTS1
resolver
uniprot_sec
Q6NVX8
resolver
uniprot_sec
Q86YT7
resolver
uniprot_sec
Q9HBP6
resolver
uniprot_sec
Q9NSW5
resolver
amino_acid_sequence
MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKKSAVRPRRSEKSLKTHEDIVALFPVPEGAPSVHHPLLTSSWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRKAV
uniprot
proteins
function
FUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:12391155, PubMed:14966270, PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. {ECO:0000269|PubMed:12391155, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:20332121, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}.
uniprot
proteins
mass_dalton
41474
uniprot
proteins
mutagenesis
MUTAGEN 208; /note="V->E: Abolishes binding to MRFAP1."; /evidence="ECO:0000269|PubMed:16407074"; MUTAGEN 234; /note="E->R: No effect on MRFAP1 binding."; /evidence="ECO:0000269|PubMed:16407074"; MUTAGEN 251; /note="Y->A: No effect on MRFAP1 binding."; /evidence="ECO:0000269|PubMed:16407074"; MUTAGEN 254; /note="N->C: Reduces binding to MRFAP1."; /evidence="ECO:0000269|PubMed:16407074
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11500496
uniprot
proteins
pubmed
12391155
uniprot
proteins
pubmed
12397079
uniprot
proteins
pubmed
12963728
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14966270
uniprot
proteins
pubmed
15196461
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16407074
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17008723
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19650074
uniprot
proteins
pubmed
20332121
uniprot
proteins
pubmed
21041482
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
37137925
uniprot
proteins
pubmed
9891081
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:21041482}.
uniprot
proteins