Pclo
entrez
56768
canonical
uniprot
Q9JKS6
canonical
ensembl
ENSRNOG00000005726
resolver
ensp
ENSRNOP00000008637
resolver
enst
ENSRNOT00000008637
resolver
genesymbol
Pclo
resolver
uniprot
D3Z9C7
resolver
uniprot
Q9JLT1
resolver
uniprot_entry
D3Z9C7_RAT
resolver
uniprot_entry
PCLO_RAT
resolver
uniprot_sec
Q9JLT1
resolver
amino_acid_sequence
MGNEASLEGEGLPEGLAAAAGAGGSGSALHPGIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVPPAAAESPSMHRKQELDSSQAPQQPGKPPDPGRPTQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDFKEEYKSSMMPGFFSDVNPLSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKSEGMAKPPLQQPSPKPIPKQQGQVKEVIQQDSSPKSVSSQQAEKVKPQAPGTGKPSQQSPAQTPAQQASPGKPVAQQPGSAKATVQQPGPAKSPAQPAGTGKSPAQPPAKTPGQQAGLEKTSSSQQPGPKSLAQTPGHGKFPLGPVKSPAQQPGTAKHPAQQPGPQTAAKVPGPTKTPAQQSGPGKTPAQQPGPTKPSPQQPIPAKPQPQQPVATKTQPQQSAPAKPQPQQPAPAKPQPQQPTPAKPQPQPPTPAKPQPQPPTATKPQPQPPTATKPHHQQPGLAKPSAQQPTKSISQTVTGRPLQPPPTSAAQTPAQGLSKTICPLCNTTELLLHIPEKANFNTCTECQSTVCSLCGFNPNPHLTEIKEWLCLNCQMQRALGGDLAAAIPSSPQPTPKAATAPTATASKSPVPSQQASPKKEPPSKQDSPKALESKKPPEPKKPPEPKKPPEPKKPPPLVKQPTLHGPTPATAPQLPVAEALPEPAPPKEPSGPLPEQAKAPVGDVEPKQPKMTETRADIQSSSTTKPDILSSQVQSQAQVKTASPLKTDSAKPSQSFPPTGEKTTPLDSKAMPRPASDSKIISQPGPGSESKDPKHIDPIQKKDEPKKAQPKGSPKPETKPVPKGSPTPSGTRPTAGQAAPPSQQPPKPQEQSRRFSLNLGGITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQQGPHPQTGPAAPSKQAPTPSQSPAAQGPAKSTGQLPPAPAKATAVKKEAKAAAAENLESKPEQAPTAKKTEKDKKPPPAKVGKPPPSEPEKAVPAHKPDKTTKPKPACPLCRTELNLGSQEPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDMGKMPPAPSGPKASPMPAPAEPSSQKTPTGTQVKGKKKEAEGKTEAEKPVPEKETASIEKTPPMVTTDQKLEESEGKKSKVSALPEKKPSEEEKAISADKKERKPPAEEKPPLEEKKPIPVDKKLPPEAKPLSSEGEEKHEILKAHVQIPEEEPTGKVAAKAGEEEQQPDSRPEALPGATPLTLPKAGEKERAVAQPQAEGSSKDGQGERSKEKTEKEEDKSDTSSSQQPKSPQGLSDTGYSSDGISGSLGEIPSLIPSDEKDLLKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLVGEKAEKKTQPQKISPEKPQDQQKTQTASETLDITISEEEIKESQEKKVSPKKDSEQGFPSRKEHKEKPELVDDLSPRRASYDSVEDSSESENSPVVRRKRRTSIGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDEEFIRSQLKEISGVGESQKREEAKGKGKGVAGKHRRLTRKSSTSFDDDAGRRHSWHDEDDETFDESPELKFRETKSQESEELVVAGGGGLRRFKTIELNSTIADKYSSESSQKKTILYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRSHGPLLPTIEDSSEEEELREEEELLKEQEKQRELEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPAAVSLYSPTDEQSVMQKEGVQKALKSAEEMYEEMMQKPHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLVEDTYNGSVDGSLLTRQEEQNGFMQQRGREQKVRLQEQIYDDPMQKISDLQKEFYELESLHSVVPQEDIVSSSYIIPESHEIVDLGSMVMSTSEEKKLLDADSAYEELMRRQQVQVTDGSSPVQTTIGDDMAESTLDFDRVQDASLTSSILSGASLTDSTSSATLSIPDVKITQQFSAEELEDEYVTDYTREIQDIIAHESLILTYSEPSESATSVPPSDTPSLTSSISSVCTTDSSSPVTTLDSLTTVYTEPADVMTKFKDSEEISSTYFPGSIIDYPEDISVSLDRTIMPESRTNEDRIVLSFSGMAPSVVESVGTKPERPQADTISTDLPISEKDLIKGKKETGDGIILEVLDAYKDKREESEAELTKISLPEPGLAQAPSSVTAPQIKEQHVSPHSVSGKISGQEKPTYRLPSGSLPVSTHPSKSRPFFRSSSLDISAQPPPPPPPPPPSPSTSSPPPTPPLPPATSPKPPTYPKKKLAVAATVTSTTIVTTHVDALTMVEAAAARRSNGLPATKMCAIAPPPVPPKPSQIPTGLVFTHRPEAIKPPIAPKPAVPQIPVTTQKPTDTCPKPTGLSLTSTMSLNLVTSADYNVPSPTSPLSPHSNKSSPRYSKSLMDTYVVITLPSEPGTPTDSSAAQAITSWPLGSPPKDLVSLETVFSVVPPMTSTEIPSASQPTLYTSGALGTFSVTPAVTASLFQTVPTSLTQFLPAEASKPEVSAVSSAVPSVAPRSVSIPIPPEPLALDRHQYKENGKLPLIGDAIDLRTIPKSEVKVTEKCMDLSASAMDVKRQTTANEVYRRQISAVQPSIINLSAASSLGTPVTMDSKTVAVVTCTDTTIYTTGTESQVGIEHAVTSPLQLTTSKHTELPYRKPSSQAFPTIRDEAPINLSLGPSAQAVTLAVTKPVTVPPVGVTNGWTDSTLSQGVADGEVVDLSTSKSHRTVVTMDESTSNVVTKIIEDDEKPVDLTAGRRAVCCDMVYTLPFGRSCTAQQPATTLPEDRFGYRDDHYQYDRSGPYGYRGIGGMKPSMSDTNLPEAGHFFYKSKNAFDYSGGTGAAVDLTSGRVSTGEVMDYSSKTTGPYPETRQVISGVGISTPQYSTARLTPPPGPQYGVGSVLRSSNGVVYSSVATPIPSTFAITTQPGSIFSTTVRDLSGIPTTDAMTSLSALHQSQPMPRSYFITTGASETDIAVTGIDINASLQTITMETLPAETMDSVPTLTTASEVFSEVVGEESTLLIVPDEDKQQQQLDLERELLELEKIKQQRFAEELEWERQEIQRFREQEKIMVQKKLEELQSMKQHLLYQQEEERQAQFMMRQETLAQQQLQLEQIQQLQQQLHQQLEEQKLRQIYQYNYDPSGTSSPQTTTEQAILEGQYAATEGSQFWATEDATTTASTVVAIEIPQSQGWYTVQSDGVTQYIAPPGILSTVSEIPLTDVVVKEEKQPKKRSSGAKVRGQYDEMGESVADDPRNLKKIVDSGVQTDDEETADRSYASRRRRTKKSVDTSVQTDDEDQDEWDMPSRSRRKARTGKYGDSTAEGDKTKPLSKVSSVAVQTVAEISVQTEPVGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTETDSDTQSPPYLGATSPPKDKKRPTPLEIGYSSSHLRADPTVQLAPSPPKSPKVLYSPISPLSPGNALEPAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQYSEGFTTKGSQTMTASGTQKKVKRTLPNPPPEEVSTGTQSTYSTMGTASRRRMCRTNTMARAKILQDIDRELDLVERESAKLRKKQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTRPSRVESQHGVERPRTAPQTEFSQFIPPQTQTEAQLVPPTSPYTQYQYSSPALPTQAPTPYTQQSHFQQQTLYHQQVSPYQTQPTFQAVATMSFTPQAQPTPTPQPSYQLPSQMMVIQQKPRQTTLYLEPKITSNYEVIRNQPLMIAPVSTDNTYAVSHLGSKYNSLDLRIGLEERSSMAGSPISSISADSFYADIDHHTSRNYVLIDDIGDITKGTAALSTVFSLHEKDLSKTDRLLRTTETRRSQEVTDFLAPLQTSSRLHSYVKADEDPMEDPYELKLLKHQIKQEFRRGTESLDHLAGLSHYYHADTSYRHFPKSEKYSISRLTLEKQAAKQLPAAILYQKQSKHKKSLIDPKMSKFSPIQESRDLEPDYPTYMSSGTSSIGGISSRARLLQDDITFGLRKNITDQQKFMGSSLGSGLGTLGNTIRSALQDEADKPYSSGSRSRPSSRPSSVYGLDLSIKRDSSSSSLRLKAQEAEALDVSFGHSSSSARTKPTSLPISQSRGRIPIVAQSSEEESPLSPVGQPMGMARAAAGPLPPISADTRDQFGSSHSLPEVQQHMREESRTRGYDRDIAFIMDDFQHAMSDSEAYHLRREETDWFDKPRESRLENGHGLDRKLPERLVHSRPLSQHQEQILQMNGKTIHYIFPHARVKITRDFKDHTGSGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGESAEHTGPLMEGMQVLEWNGVPLTSKTYEEVQSIINQQSGEAEICVRLDLNMLSDSENPQHLELHEPPKVDKAKSPGVDPKQLAAELQKVSLQQSPLVMSSVVEKGSHAHSGPTSAGSSSVPSPGQPGSPSVSKKKHSSTKPTDGPKAASHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEYKRRTKYVQKSLNPEWNQTVIYKSISMEQLMKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQNSQQSPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVAQTHLEDAGVAIAAAEAAVQQLRIQPTKPTNHRPAESSVSTGSSGSSVGSGYSVDSEGSSCVAGEPNLLPIPRIGKMGQNGQDPVKQPGMGATDTEGKTQVMGEIKLALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPDLYVKLYVINISTQKKVIKKKTRVCRHDREPSFNETFRFSLSPAGHSLQILLFSNGGKFMKKTLIGEACIWLDKVDLRKRIVNWHKLLVSPTQTH
uniprot
proteins
function
FUNCTION: Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:22875941). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:22875941). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (PubMed:27907191). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (PubMed:29194628). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (PubMed:23403927, PubMed:27907191). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (PubMed:25652077). {ECO:0000269|PubMed:22875941, ECO:0000269|PubMed:23403927, ECO:0000269|PubMed:25652077, ECO:0000269|PubMed:27907191, ECO:0000269|PubMed:29194628}.
uniprot
proteins
mass_dalton
552716
uniprot
proteins
mutagenesis
MUTAGEN 4668; /note="D->A: Complete loss of calcium-binding and calcium-dependent phospholipid binding activity."; /evidence="ECO:0000269|PubMed:11285225"; MUTAGEN 4674; /note="D->A: Complete loss of calcium-binding and calcium-dependent phospholipid binding activity."; /evidence="ECO:0000269|PubMed:11285225"; MUTAGEN 4688..4689; /note="VM->SS: 10-fold increase in affinity for calcium."; /evidence="ECO:0000269|PubMed:11285225"; MUTAGEN 4688; /note="V->S: Small increase in affinity for calcium."; /evidence="ECO:0000269|PubMed:11285225"; MUTAGEN 4689; /note="M->S: Increased affinity for calcium."; /evidence="ECO:0000269|PubMed:11285225"; MUTAGEN 4690..4691; /note="VV->SS: 10-fold increase in affinity for calcium."; /evidence="ECO:0000269|PubMed:11285225"; MUTAGEN 4692..4693; /note="QN->AA: Moderate increase in affinity for calcium."; /evidence="ECO:0000269|PubMed:11285225"; MUTAGEN 4694; /note="A->S: No effect on calcium-binding activity."; /evidence="ECO:0000269|PubMed:11285225
uniprot
proteins
pubmed
10707984
uniprot
proteins
pubmed
11285225
uniprot
proteins
pubmed
12473661
uniprot
proteins
pubmed
14718922
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
22875941
uniprot
proteins
pubmed
23403927
uniprot
proteins
pubmed
25652077
uniprot
proteins
pubmed
27907191
uniprot
proteins
pubmed
29194628
uniprot
proteins
sequence_length
5085
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Presynaptic active zone {ECO:0000250|UniProtKB:Q9QYX7}. Note=Colocalizes with BSN in developing axons. {ECO:0000269|PubMed:11285225}.
uniprot
proteins