PGF
entrez
5228
canonical
uniprot
P49763
canonical
ensembl
ENSG00000119630
resolver
ensp
ENSP00000238607
resolver
ensp
ENSP00000451040
resolver
ensp
ENSP00000451413
resolver
ensp
ENSP00000533302
resolver
enst
ENST00000238607
resolver
genesymbol
PGF
resolver
genesymbol_syn
PGFL
resolver
genesymbol_syn
PLGF
resolver
hgnc
HGNC:8893
resolver
uniprot
G3XA84
resolver
uniprot
Q07101
resolver
uniprot
Q53XY6
resolver
uniprot
Q86TW6
resolver
uniprot
Q9BV78
resolver
uniprot
Q9Y6S8
resolver
uniprot_entry
G3XA84_HUMAN
resolver
uniprot_entry
PLGF_HUMAN
resolver
uniprot_entry
Q53XY6_HUMAN
resolver
uniprot_entry
Q86TW6_HUMAN
resolver
uniprot_sec
Q07101
resolver
uniprot_sec
Q9BV78
resolver
uniprot_sec
Q9Y6S8
resolver
amino_acid_sequence
MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRHSPGRQSPDMPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWPSSPVPEEIPRMHPGRNGKKQQRKPLREKMKPERCGDAVPRR
uniprot
proteins
function
FUNCTION: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. {ECO:0000269|PubMed:21215706}.
uniprot
proteins
mass_dalton
24789
uniprot
proteins
post_translational_modification
PTM: N-glycosylated.
uniprot
proteins
protein_family
PDGF/VEGF growth factor family
uniprot
proteins
pubmed
11069911
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14568677
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1924389
uniprot
proteins
pubmed
21215706
uniprot
proteins
pubmed
7681160
uniprot
proteins
pubmed
7929268
uniprot
proteins
pubmed
8148155
uniprot
proteins
pubmed
9207183
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
uniprot
proteins