Rusc1
entrez
72296
canonical
uniprot
Q8BG26
canonical
ensembl
ENSMUSG00000041263
resolver
ensp
ENSMUSP00000056640
resolver
ensp
ENSMUSP00000088447
resolver
ensp
ENSMUSP00000130477
resolver
genesymbol
Rusc1
resolver
genesymbol_syn
Nesca
resolver
uniprot
Q3TDG5
resolver
uniprot
Q6PHT9
resolver
uniprot_entry
Q3TDG5_MOUSE
resolver
uniprot_entry
RUSC1_MOUSE
resolver
uniprot_sec
Q6PHT9
resolver
amino_acid_sequence
MLSPQRALLCNLNHIHLQHVSLGLHLSRRPELREGPLSTPPPPGDTGGKESRGPCSGTLVDANSNSPAVPCRCCQEHGSSIENQQDPSQEEEAVSPSDPGCSSSLSSCSDLSPDESPVSVYSRDLPGNEDANPQPSTLELGSPLAPAGPSTCSPDSFCCSPDSCSGISSPPGPDLDSNCNALTTCQDLPSPGLEEEEDSGEQDLATSELSETEDGRIDAGKAEPSWKINPIWKIDTEKTEAGWKTIEDSDSGRKTDENTNSSLKTESGKLASCLNTNSGSKIDAGKTDGGWRGDVSQEPVPHRTITSFHELAQKRKRGPGLPLVPQAKKDRSDWLIVFSPDTELPPTGSLGGSLAPPREVTTFKELRSRSRAQPPPVPPRDPPAGWALVPPRPPPPPVPPRRKKNRLGLQPIAEGLSEEGRAASPRAGEEASASQEPEEPRAHAVVRSSWSFAGVPGAQRLWMAEAQSGTGQLQEQKKGLLIAVSASVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLTTLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSCTHSMGSLYSQVSRLAPLSSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGSCPSLATELLLLLQPLSVLTFHLDLLFEHHHHLPVGLQQAPAPSCPPPALQQTMQAVLHWGERLAQSLRGTSGESTTDSSTPSARPPAGSWWDQLTQASRVYASGGTEGFPLLRWGPRRHGTTAEAAQEAPPPTEQTTPGRSVWLGRLFGVPGCPSETESGAFKSRRPSSWLPPTVSVLALVKRGTPPETPPEALVSSPGSVVQADRAVRALCDHTAAGPDQLSFQRGELLRVIATVDEDWLRCGRDGVEGLVPVGYTSLVL
uniprot
proteins
function
FUNCTION: Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. Signaling adapter which plays a role in neuronal differentiation. Involved in regulation of NGF-dependent neurite outgrowth (By similarity). May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins (PubMed:22404429). Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway (By similarity). {ECO:0000250|UniProtKB:Q9BVN2, ECO:0000269|PubMed:22404429}.
uniprot
proteins
mass_dalton
95195
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues following nuclear translocation. {ECO:0000250|UniProtKB:Q9BVN2}.; PTM: Polyubiquitinated; polyubiquitination involves TRAF6. {ECO:0000250|UniProtKB:Q9BVN2}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22404429
uniprot
proteins
sequence_length
893
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22404429}. Nucleus {ECO:0000250|UniProtKB:Q9BVN2}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22404429}. Cytoplasmic vesicle {ECO:0000305|PubMed:22404429}. Early endosome {ECO:0000305|PubMed:22404429}. Postsynaptic density {ECO:0000269|PubMed:22404429}. Golgi apparatus {ECO:0000305|PubMed:22404429}. Note=Translocated to the nuclear envelope upon stimulation with NGF (By similarity). Associated with membranes and microtubules (PubMed:22404429). {ECO:0000250|UniProtKB:Q9BVN2, ECO:0000269|PubMed:22404429}.
uniprot
proteins