CCDC25
entrez
55246
canonical
uniprot
Q86WR0
canonical
ensembl
ENSG00000147419
resolver
ensp
ENSP00000348933
resolver
ensp
ENSP00000428000
resolver
ensp
ENSP00000429861
resolver
enst
ENST00000524084
resolver
genesymbol
CCDC25
resolver
hgnc
HGNC:25591
resolver
uniprot
G3V121
resolver
uniprot
Q0P663
resolver
uniprot
Q96SI2
resolver
uniprot
Q9NV98
resolver
uniprot_entry
CCD25_HUMAN
resolver
uniprot_entry
G3V121_HUMAN
resolver
uniprot_sec
Q0P663
resolver
uniprot_sec
Q96SI2
resolver
uniprot_sec
Q9NV98
resolver
amino_acid_sequence
MVFYFTSSSVNSSAYTIYMGKDKYENEDLIKHGWPEDIWFHVDKLSSAHVYLRLHKGENIEDIPKEVLMDCAHLVKANSIQGCKMNNVNVVYTPWSNLKKTADMDVGQIGFHRQKDVKIVTVEKKVNEILNRLEKTKVERFPDLAAEKECRDREERNEKKAQIQEMKKREKEEMKKKREMDELRSYSSLMKVENMSSNQDGNDSDEFM
uniprot
proteins
function
FUNCTION: Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility (PubMed:32528174). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:32528174). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (PubMed:32528174). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (PubMed:32528174). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (PubMed:32528174). {ECO:0000269|PubMed:32528174}.
uniprot
proteins
mass_dalton
24479
uniprot
proteins
mutagenesis
MUTAGEN 16..20; /note="TIYMG->AAAAA: Does not affect binding to neutrophil extracellular traps (NETs)."; /evidence="ECO:0000269|PubMed:32528174"; MUTAGEN 21..25; /note="KDKYE->AAAAA: Abolished binding to neutrophil extracellular traps (NETs)."; /evidence="ECO:0000269|PubMed:32528174
uniprot
proteins
protein_family
CCDC25 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
32528174
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32528174}; Single-pass membrane protein {ECO:0000305|PubMed:32528174}. Endomembrane system {ECO:0000269|PubMed:32528174}. Note=Localizes to cytoplasmic membrane in tumor cells. {ECO:0000269|PubMed:32528174}.
uniprot
proteins
transmembrane_region
TRANSMEM 67..83; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins