TAPBPL
entrez
55080
canonical
uniprot
Q9BX59
canonical
ensembl
ENSG00000139192
resolver
ensp
ENSP00000266556
resolver
genesymbol
TAPBPL
resolver
hgnc
HGNC:30683
resolver
uniprot
Q9NWB8
resolver
uniprot_entry
TPSNR_HUMAN
resolver
uniprot_sec
Q9NWB8
resolver
amino_acid_sequence
MGTQEGWCLLLCLALSGAAETKPHPAEGQWRAVDVVLDCFLAKDGAHRGALASSEDRARASLVLKQVPVLDDGSLEDFTDFQGGTLAQDDPPIIFEASVDLVQIPQAEALLHADCSGKEVTCEISRYFLQMTETTVKTAAWFMANMQVSGGGPSISLVMKTPRVTKNEALWHPTLNLPLSPQGTVRTAVEFQVMTQTQSLSFLLGSSASLDCGFSMAPGLDLISVEWRLQHKGRGQLVYSWTAGQGQAVRKGATLEPAQLGMARDASLTLPGLTIQDEGTYICQITTSLYRAQQIIQLNIQASPKVRLSLANEALLPTLICDIAGYYPLDVVVTWTREELGGSPAQVSGASFSSLRQSVAGTYSISSSLTAEPGSAGATYTCQVTHISLEEPLGASTQVVPPERRTALGVIFASSLFLLALMFLGLQRRQAPTGLGLLQAERWETTSCADTQSSHLHEDRTARVSQPS
uniprot
proteins
function
FUNCTION: Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). {ECO:0000269|PubMed:23401559, ECO:0000269|PubMed:26869717}.
uniprot
proteins
mass_dalton
50183
uniprot
proteins
mutagenesis
MUTAGEN 115; /note="C->A: No effect on cell surface expression of MR1-metabolite antigen complex."; /evidence="ECO:0000269|PubMed:32958637"; MUTAGEN 226; /note="E->K: Loss of MR1 expression at the cell surface; when associated with Glu-228; Ser-230 and Ser-293."; /evidence="ECO:0000269|PubMed:35725941"; MUTAGEN 228; /note="R->E: Loss of MR1 expression at the cell surface; when associated with Glu-226; Ser-230 and Ser-293."; /evidence="ECO:0000269|PubMed:35725941"; MUTAGEN 230; /note="Q->S: Loss of MR1 expression at the cell surface; when associated with Glu-226; Ser-228 and Ser-293."; /evidence="ECO:0000269|PubMed:35725941"; MUTAGEN 282; /note="I->K: Decreases cell surface expression of MR1-metabolite antigen complex."; /evidence="ECO:0000269|PubMed:32958637"; MUTAGEN 293; /note="Q->S: Loss of MR1 expression at the cell surface; when associated with Glu-226; Ser-228 and Ser-230."; /evidence="ECO:0000269|PubMed:35725941
uniprot
proteins
pubmed
11920573
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
23401559
uniprot
proteins
pubmed
24444341
uniprot
proteins
pubmed
26869717
uniprot
proteins
pubmed
32958637
uniprot
proteins
pubmed
35725941
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Microsome membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Golgi apparatus membrane {ECO:0000269|PubMed:23401559}; Single-pass type I membrane protein {ECO:0000269|PubMed:23401559}. Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface (PubMed:11920573).
uniprot
proteins
transmembrane_region
TRANSMEM 406..426; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins