RNF6
entrez
6049
canonical
uniprot
Q9Y252
canonical
ensembl
ENSG00000127870
resolver
ensp
ENSP00000342121
resolver
ensp
ENSP00000370982
resolver
ensp
ENSP00000371000
resolver
ensp
ENSP00000572257
resolver
ensp
ENSP00000572260
resolver
ensp
ENSP00000572265
resolver
ensp
ENSP00000615774
resolver
ensp
ENSP00000698952
resolver
genesymbol
RNF6
resolver
genesymbol_syn
SPG2
resolver
hgnc
HGNC:10069
resolver
uniprot
A0A024RDP2
resolver
uniprot
A0A0S2Z4G9
resolver
uniprot
B4DDP0
resolver
uniprot
Q5W0H0
resolver
uniprot
Q9BZP5
resolver
uniprot
Q9UF41
resolver
uniprot_entry
A0A024RDP2_HUMAN
resolver
uniprot_entry
A0A0S2Z4G9_HUMAN
resolver
uniprot_entry
RNF6_HUMAN
resolver
uniprot_sec
B4DDP0
resolver
uniprot_sec
Q5W0H0
resolver
uniprot_sec
Q9BZP5
resolver
uniprot_sec
Q9UF41
resolver
amino_acid_sequence
MNQSRSRSDGGSEETLPQDHNHHENERRWQQERLHREEAYYQFINELNDEDYRLMRDHNLLGTPGEITSEELQQRLDGVKEQLASQPDLRDGTNYRDSEVPRESSHEDSLLEWLNTFRRTGNATRSGQNGNQTWRAVSRTNPNNGEFRFSLEIHVNHENRGFEIHGEDYTDIPLSDSNRDHTANRQQRSTSPVARRTRSQTSVNFNGSSSNIPRTRLASRGQNPAEGSFSTLGRLRNGIGGAAGIPRANASRTNFSSHTNQSGGSELRQREGQRFGAAHVWENGARSNVTVRNTNQRLEPIRLRSTSNSRSRSPIQRQSGTVYHNSQRESRPVQQTTRRSVRRRGRTRVFLEQDRERERRGTAYTPFSNSRLVSRITVEEGEESSRSSTAVRRHPTITLDLQVRRIRPGENRDRDSIANRTRSRVGLAENTVTIESNSGGFRRTISRLERSGIRTYVSTITVPLRRISENELVEPSSVALRSILRQIMTGFGELSSLMEADSESELQRNGQHLPDMHSELSNLGTDNNRSQHREGSSQDRQAQGDSTEMHGENETTQPHTRNSDSRGGRQLRNPNNLVETGTLPILRLAHFFLLNESDDDDRIRGLTKEQIDNLSTRHYEHNSIDSELGKICSVCISDYVTGNKLRQLPCMHEFHIHCIDRWLSENCTCPICRQPVLGSNIANNG
uniprot
proteins
disease_involvement
DISEASE: Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269|PubMed:12154016}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation (By similarity). Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover (By similarity). Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity (PubMed:19345326). May also bind DNA and function as a transcriptional regulator (By similarity). Mediates polyubiquitination of QKI in macrophages, leading to its degradation (By similarity). {ECO:0000250|UniProtKB:Q9DBU5, ECO:0000269|PubMed:19345326}.
uniprot
proteins
mass_dalton
78091
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:19345326}.
uniprot
proteins
protein_family
RNF12 family
uniprot
proteins
pubmed
10331950
uniprot
proteins
pubmed
12154016
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18368307
uniprot
proteins
pubmed
19345326
uniprot
proteins
sequence_length
685
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19345326}. Cytoplasm {ECO:0000269|PubMed:19345326}. Cell projection, axon {ECO:0000250|UniProtKB:Q9DBU5}. Nucleus, PML body {ECO:0000250|UniProtKB:Q9DBU5}. Note=Localizes to the PML nuclear bodies in Sertoli cells. {ECO:0000250|UniProtKB:Q9DBU5}.
uniprot
proteins