Cx3cl1
entrez
20312
canonical
uniprot
O35188
canonical
ensembl
ENSMUSG00000031778
resolver
ensp
ENSMUSP00000034230
resolver
enst
ENSMUST00000034230
resolver
genesymbol
Cx3cl1
resolver
genesymbol_syn
Cx3c
resolver
genesymbol_syn
Fkn
resolver
genesymbol_syn
Scyd1
resolver
uniprot
O35933
resolver
uniprot
Q91V44
resolver
uniprot_entry
X3CL1_MOUSE
resolver
uniprot_sec
O35933
resolver
uniprot_sec
Q91V44
resolver
amino_acid_sequence
MAPSPLAWLLRLAAFFHLCTLLPGQHLGMTKCEIMCDKMTSRIPVALLIRYQLNQESCGKRAIVLETTQHRRFCADPKEKWVQDAMKHLDHQAAALTKNGGKFEKRVDNVTPGITLATRGLSPSALTKPESATLEDLALELTTISQEARGTMGTSQEPPAAVTGSSLSTSEAQDAGLTAKPQSIGSFEAADISTTVWPSPAVYQSGSSSWAEEKATESPSTTAPSPQVSTTSPSTPEENVGSEGQPPWVQGQDLSPEKSLGSEEINPVHTDNFQERGPGNTVHPSVAPISSEETPSPELVASGSQAPKIEEPIHATADPQKLSVLITPVPDTQAATRRQAVGLLAFLGLLFCLGVAMFAYQSLQGCPRKMAGEMVEGLRYVPRSCGSNSYVLVPV
uniprot
proteins
function
FUNCTION: Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1 (PubMed:10187784, PubMed:18971423). The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:10187784, PubMed:10382755, PubMed:18971423, PubMed:9177350). Regulates leukocyte adhesion and migration processes at the endothelium (PubMed:10382755, PubMed:9177350). Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner (By similarity). In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins (By similarity). In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (By similarity). {ECO:0000250|UniProtKB:P78423, ECO:0000269|PubMed:10187784, ECO:0000269|PubMed:10382755, ECO:0000269|PubMed:18971423, ECO:0000269|PubMed:9177350}.; FUNCTION: [Processed fractalkine]: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. {ECO:0000250|UniProtKB:P78423}.; FUNCTION: [Fractalkine]: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. {ECO:0000250|UniProtKB:P78423}.
uniprot
proteins
mass_dalton
42099
uniprot
proteins
post_translational_modification
PTM: A soluble short 80 kDa form may be released by proteolytic cleavage from the long membrane-anchored form. {ECO:0000269|PubMed:10382755}.
uniprot
proteins
protein_family
Intercrine delta family
uniprot
proteins
pubmed
10187784
uniprot
proteins
pubmed
10382755
uniprot
proteins
pubmed
10508268
uniprot
proteins
pubmed
11287620
uniprot
proteins
pubmed
12569158
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18971423
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9177350
uniprot
proteins
pubmed
9479488
uniprot
proteins
pubmed
9845323
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9177350}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Processed fractalkine]: Secreted {ECO:0000269|PubMed:10382755}.
uniprot
proteins
transmembrane_region
TRANSMEM 337..357; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins