Ehd2
entrez
259300
canonical
uniprot
Q8BH64
canonical
ensembl
ENSMUSG00000074364
resolver
ensp
ENSMUSP00000096397
resolver
ensp
ENSMUSP00000274896
resolver
ensp
ENSMUSP00000274898
resolver
enst
ENSMUST00000098799
resolver
genesymbol
Ehd2
resolver
uniprot
Q8BL28
resolver
uniprot_entry
EHD2_MOUSE
resolver
uniprot_sec
Q8BL28
resolver
activity_regulation
ACTIVITY REGULATION: The very low intrinsic ATPase activity is increased upon interaction with liposomes. {ECO:0000269|PubMed:17914359}.
uniprot
proteins
amino_acid_sequence
MFSWLKKGGARGQRPEAIRTVTSSLKELYRTKLLPLEEHYRFGSFHSPALEDADFDGKPMVLVAGQYSTGKTSFIQYLLEQEVPGSRVGPEPTTDCFVAVMHGETEGTVPGNALVVDPEKPFRKLNPFGNTFLNRFMCAQLPNQVLESISIIDTPGILSGAKQRVSRGYDFPAVLRWFAERVDLIILLFDAHKLEISDEFSEAIGALRGHEDKIRVVLNKADMVETQQLMRVYGALMWALGKVVGTPEVLRVYIGSFWSQPLLVPDNRRLFELEEQDLFRDIQGLPRHAALRKLNDLVKRARLVRVHAYIISYLKKEMPTVFGKENKKKQLILKLPVIFAKIQLEHHISPGDFPDCQKMQELLMAHDFTKFHSLKPKLLEALDDMLAQDIAKLMPLLRQEELESVEAGVQGGAFEGTRMGPFVERGPDEAIEDGEEGSEDDAEWVVTKDKSKYDEIFYNLAPADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGMLDDEEFALASHLIEAKLEGHGLPTNLPRRLVPPSKRRQKGSAE
uniprot
proteins
function
FUNCTION: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:24508342). Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4 (PubMed:14676205). Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (PubMed:18502764, PubMed:21177873). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q9NZN4, ECO:0000269|PubMed:14676205, ECO:0000269|PubMed:18502764, ECO:0000269|PubMed:21177873, ECO:0000269|PubMed:24508342}.
uniprot
proteins
mass_dalton
61174
uniprot
proteins
mutagenesis
MUTAGEN 65; /note="G->R: Inhibits myoblast fusion."; /evidence="ECO:0000269|PubMed:18502764"; MUTAGEN 72; /note="T->A: Abolishes ATP binding."; /evidence="ECO:0000269|PubMed:17914359"; MUTAGEN 94; /note="T->A: Abolishes increase of intrinsic ATPase activity upon interaction with membranes."; /evidence="ECO:0000269|PubMed:17914359"; MUTAGEN 157; /note="I->Q: Increases intrinsic ATPase activity."; /evidence="ECO:0000269|PubMed:17914359"; MUTAGEN 167; /note="R->E: Increases intrinsic ATPase activity."; /evidence="ECO:0000269|PubMed:17914359"; MUTAGEN 322; /note="F->A: Abolishes localization at the plasma membrane; reduces increase of intrinsic ATPase activity upon interaction with membranes."; /evidence="ECO:0000269|PubMed:17914359"; MUTAGEN 324; /note="K->D: Abolishes localization at the plasma membrane."; /evidence="ECO:0000269|PubMed:17914359"; MUTAGEN 327; /note="K->D: Abolishes localization at the plasma membrane; abolishes increase of intrinsic ATPase activity upon interaction with membranes."; /evidence="ECO:0000269|PubMed:17914359"; MUTAGEN 328; /note="K->D: Abolishes localization at the plasma membrane; reduces increase of intrinsic ATPase activity upon interaction with membranes."; /evidence="ECO:0000269|PubMed:17914359"; MUTAGEN 329; /note="K->D: Abolishes localization at the plasma membrane."; /evidence="ECO:0000269|PubMed:17914359
uniprot
proteins
protein_family
Dynamin/Fzo/YdjA family
uniprot
proteins
protein_family
EHD subfamily
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
14676205
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17914359
uniprot
proteins
pubmed
18502764
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21177873
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24508342
uniprot
proteins
sequence_length
543
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14676205}; Peripheral membrane protein {ECO:0000269|PubMed:14676205}; Cytoplasmic side {ECO:0000269|PubMed:14676205}. Membrane, caveola {ECO:0000269|PubMed:24508342}; Peripheral membrane protein {ECO:0000269|PubMed:24508342}; Cytoplasmic side {ECO:0000269|PubMed:24508342}. Endosome membrane {ECO:0000250|UniProtKB:Q4V8H8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q4V8H8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q4V8H8}. Cytoplasm, cytosol {ECO:0000269|PubMed:14676205}. Note=Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin (PubMed:14676205). Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (PubMed:18502764). {ECO:0000269|PubMed:14676205, ECO:0000269|PubMed:18502764}.
uniprot
proteins