NME3
entrez
4832
canonical
uniprot
Q13232
canonical
ensembl
ENSG00000103024
resolver
ensp
ENSP00000219302
resolver
ensp
ENSP00000456160
resolver
ensp
ENSP00000575019
resolver
ensp
ENSP00000648613
resolver
enst
ENST00000219302
resolver
genesymbol
NME3
resolver
hgnc
HGNC:7851
resolver
uniprot
Q9BWH4
resolver
uniprot_entry
NDKC_HUMAN
resolver
uniprot_sec
Q9BWH4
resolver
amino_acid_sequence
MICLVLTIFANLFPAACTGAHERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQASEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLDVVRTSRALIGATNPADAPPGTIRGDFCIEVGKNLIHGSDSVESARREIALWFRADELLCWEDSAGHWLYE
uniprot
proteins
disease_involvement
DISEASE: Note=A substitution in the initiation codon of the NME3 gene substitution (p.Met1Val), resulting in lack of full protein expression has been found in a female infant with an early-onset fatal neurodegenerative disorder. {ECO:0000269|PubMed:30587587}.
uniprot
proteins
ec_number
2.7.4.6
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis (PubMed:11277919, PubMed:30587587, PubMed:39337255). In vitro, can also use other phosphate donors such as UTP and GTP (PubMed:30587587, PubMed:39337255). Independently of its nucleoside diphosphate kinase activity, involved in mitochondrial membrane tethering, a prerequisite for fusion through direct membrane-binding and hexamerization (PubMed:30587587, PubMed:37584589). Involved in DNA repair of both single- and double-stranded breaks by associating with the ribonucleotide reductase (RNR) complex via interaction with the histone acetyltransferase KAT5, facilitating recruitment to DNA damage sites independently of its kinase activity (PubMed:26945015). Inhibits granulocyte differentiation (PubMed:7638209). May be required for ciliary function during renal development (By similarity). {ECO:0000250|UniProtKB:Q9PTF3, ECO:0000269|PubMed:11277919, ECO:0000269|PubMed:26945015, ECO:0000269|PubMed:30587587, ECO:0000269|PubMed:37584589, ECO:0000269|PubMed:39337255, ECO:0000269|PubMed:7638209}.
uniprot
proteins
mass_dalton
19015
uniprot
proteins
mutagenesis
MUTAGEN 9; /note="F->A: Lacks phosphatidic acid binding activity; when associated with A-13. Decreases NME3 enrichement at the mitochondrial contact interface; when associated with A-13."; /evidence="ECO:0000269|PubMed:37584589"; MUTAGEN 13; /note="F->A: Lacks phosphatidic acid binding activity; when associated with A-9. Decreases NME3 enrichement at the mitochondrial contact interface; when associated with A-9."; /evidence="ECO:0000269|PubMed:37584589"; MUTAGEN 40; /note="E->D: Impairs hexamerization; when associated with D-46. Decreases mitochondrial tethering activity; when associated with D-46."; /evidence="ECO:0000269|PubMed:30587587, ECO:0000269|PubMed:37584589"; MUTAGEN 46; /note="E->D: Impairs hexamerization; when associated with D-40. Decreases mitochondrial tethering activity; when associated with D-40."; /evidence="ECO:0000269|PubMed:30587587, ECO:0000269|PubMed:37584589"; MUTAGEN 135; /note="H->Q: Lacks of nucleoside diphosphate kinase activity. Does not affect mitochondrial fusion activity."; /evidence="ECO:0000269|PubMed:30587587
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation is Mg(2+)-dependent. {ECO:0000269|PubMed:39337255}.
uniprot
proteins
protein_family
NDK family
uniprot
proteins
pubmed
11157797
uniprot
proteins
pubmed
11277919
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
26945015
uniprot
proteins
pubmed
30111592
uniprot
proteins
pubmed
30587587
uniprot
proteins
pubmed
37584589
uniprot
proteins
pubmed
39337255
uniprot
proteins
pubmed
7638209
uniprot
proteins
sequence_length
169
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:30587587, ECO:0000269|PubMed:37584589}; Peripheral membrane protein {ECO:0000269|PubMed:30587587, ECO:0000269|PubMed:37584589}. Cytoplasm {ECO:0000269|PubMed:26945015}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9WV85}.
uniprot
proteins