Lrrc58
entrez
320184
canonical
uniprot
Q3UGP9
canonical
ensembl
ENSMUSG00000034158
resolver
ensp
ENSMUSP00000077779
resolver
enst
ENSMUST00000078717
resolver
genesymbol
Lrrc58
resolver
uniprot
B2RU81
resolver
uniprot
Q8BX06
resolver
uniprot_entry
LRC58_MOUSE
resolver
uniprot_sec
B2RU81
resolver
uniprot_sec
Q8BX06
resolver
amino_acid_sequence
MEEAALGEAELNWSRLSVSAEALESELEARAEERRGAREALLRLLLPYNRLTSLPRALGGGFPHLQLLDVSGNSLTALGPELLTLSGLRTLLARNNRLGGPGSLPKGLAQSPLCRSLQVLNLSGNCFQELPASLLELRALQTLSLGGNQLQSIPAEIENLRSLECLYLGGNFIKEIPPELANLPSLNYLVLCDNKIQSVPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKIRSISYTPYDLPGNLLRYLGSASNCPNPKCGGVYFDCCVRQIKFVDFCGKYRLPLMHYLCSPECSSPCSSASHSSTSQSESDSEDEASVAAHRMQKVLLG
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CDO1 (PubMed:40963025). The ECS(LRRC58) complex acts as a regulator of cysteine catabolism by mediating ubiquitination and degradation of CDO1, the rate-limiting enzyme of the cysteine catabolic process to taurine (PubMed:40963025). L-cysteine abundance regulates ECS(LRRC58)-mediated ubiquitination of CDO1: the complex promotes ubiquitination and degradation of CDO1 in presence of high level of cysteine, but not when cysteine abundance is low (By similarity). {ECO:0000250|UniProtKB:Q96CX6, ECO:0000269|PubMed:40963025}.
uniprot
proteins
mass_dalton
40139
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:40963025}.
uniprot
proteins
protein_family
LRRC58 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
40963025
uniprot
proteins
sequence_length
366
uniprot
proteins