Sae1
entrez
308384
canonical
uniprot
Q6AXQ0
canonical
ensembl
ENSRNOG00000015128
resolver
ensembl
ENSRNOG00055016958
resolver
ensembl
ENSRNOG00060021131
resolver
ensembl
ENSRNOG00065034014
resolver
ensp
ENSRNOP00000020402
resolver
ensp
ENSRNOP00055023205
resolver
ensp
ENSRNOP00060030192
resolver
ensp
ENSRNOP00065048060
resolver
enst
ENSRNOT00000020402
resolver
enst
ENSRNOT00055028825
resolver
enst
ENSRNOT00060036681
resolver
enst
ENSRNOT00065058411
resolver
genesymbol
Sae1
resolver
genesymbol_syn
Uble1a
resolver
uniprot_entry
SAE1_RAT
resolver
amino_acid_sequence
MVEKEEVSGGGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLIVGMKGLGAEIAKNLILAGVKGLTMLDHEQVSPEDLGAQFLIRTGSVGQNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTEFDAVCLTCCSKDVIIKVDQICHRNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVTKVSQGVEDGPDAKRAKLDSSETTMVKKKVLFCPVKEALAVDWSGEKAQAALKRTAPDYFLLQVLLKFRTDKGRDPTSDSYSEDAELLLQIRNDVFDSLGVSPDLLPDDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGSGIVECLGPQ
uniprot
proteins
function
FUNCTION: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
38513
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein sumoylation.
uniprot
proteins
protein_family
Ubiquitin-activating E1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins