FLYWCH1
entrez
84256
canonical
uniprot
Q4VC44
canonical
ensembl
ENSG00000059122
resolver
ensp
ENSP00000253928
resolver
ensp
ENSP00000399938
resolver
ensp
ENSP00000575986
resolver
ensp
ENSP00000575991
resolver
ensp
ENSP00000614680
resolver
ensp
ENSP00000614686
resolver
ensp
ENSP00000614688
resolver
ensp
ENSP00000671860
resolver
ensp
ENSP00000701506
resolver
ensp
ENSP00000701509
resolver
ensp
ENSP00000701515
resolver
ensp
ENSP00000701517
resolver
genesymbol
FLYWCH1
resolver
genesymbol_syn
KIAA1552
resolver
hgnc
HGNC:25404
resolver
uniprot
D3DUA1
resolver
uniprot
Q6ZSQ1
resolver
uniprot
Q8WV62
resolver
uniprot
Q9BQG6
resolver
uniprot
Q9BUS5
resolver
uniprot
Q9HCM0
resolver
uniprot_entry
FWCH1_HUMAN
resolver
uniprot_sec
D3DUA1
resolver
uniprot_sec
Q6ZSQ1
resolver
uniprot_sec
Q8WV62
resolver
uniprot_sec
Q9BQG6
resolver
uniprot_sec
Q9BUS5
resolver
uniprot_sec
Q9HCM0
resolver
amino_acid_sequence
MPLPEPSEQEGESVKAGQEPSPKPGTDVIPAAPRKPREFSKLVLLTASDQDEDGVGSKPQEVHCVLSLEMAGPATLASTLQILPVEEQGGVVQPALEMPEQKCSKLDAAAPQSLEFLRTPFGGRLLVLESFLYKQEKAVGDKVYWKCRQHAELGCRGRAITRGLRATVMRGHCHAPDEQGLEARRQREKLPSLALPEGLGEPQGPEGPGGRVEEPLEGVGPWQCPEEPEPTPGLVLSKPALEEEEAPRALSLLSLPPKKRSILGLGQARPLEFLRTCYGGSFLVHESFLYKREKAVGDKVYWTCRDHALHGCRSRAITQGQRVTVMRGHCHQPDMEGLEARRQQEKAVETLQAGQDGPGSQVDTLLRGVDSLLYRRGPGPLTLTRPRPRKRAKVEDQELPTQPEAPDEHQDMDADPGGPEFLKTPLGGSFLVYESFLYRREKAAGEKVYWTCRDQARMGCRSRAITQGRRVTVMRGHCHPPDLGGLEALRQREKRPNTAQRGSPGGPEFLKTPLGGSFLVYESFLYRREKAAGEKVYWTCRDQARMGCRSRAITQGRRVMVMRRHCHPPDLGGLEALRQREHFPNLAQWDSPDPLRPLEFLRTSLGGRFLVHESFLYRKEKAAGEKVYWMCRDQARLGCRSRAITQGHRIMVMRSHCHQPDLAGLEALRQRERLPTTAQQEDPEKIQVQLCFKTCSPESQQIYGDIKDVRLDGESQ
uniprot
proteins
function
FUNCTION: Transcription cofactor (PubMed:30097457). Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding (PubMed:30097457). May play a role in DNA-damage response signaling (PubMed:33924684). Binds specifically to DNA sequences at peri-centromeric chromatin loci. {ECO:0000269|PubMed:30097457, ECO:0000269|PubMed:33924684, ECO:0000269|PubMed:34408139}.
uniprot
proteins
mass_dalton
80108
uniprot
proteins
pubmed
10997877
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
30097457
uniprot
proteins
pubmed
33924684
uniprot
proteins
pubmed
34408139
uniprot
proteins
sequence_length
716
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33924684}. Chromosome, centromere {ECO:0000269|PubMed:34408139}. Note=Localized to peri-centromeric, H3K9me3-marked heterochromatin. {ECO:0000269|PubMed:34408139}.
uniprot
proteins