FADS1
entrez
3992
canonical
uniprot
O60427
canonical
ensembl
ENSG00000149485
resolver
ensp
ENSP00000322229
resolver
ensp
ENSP00000441403
resolver
enst
ENST00000350997
resolver
genesymbol
FADS1
resolver
genesymbol_syn
FADSD5
resolver
hgnc
HGNC:3574
resolver
uniprot
A0A0A0MR51
resolver
uniprot
A8K0I7
resolver
uniprot
B2RAI0
resolver
uniprot
Q53GM5
resolver
uniprot
Q8N3A6
resolver
uniprot
Q8NCC7
resolver
uniprot
Q8NCG0
resolver
uniprot
Q96I39
resolver
uniprot
Q96SV3
resolver
uniprot
Q96T10
resolver
uniprot
Q9NRP8
resolver
uniprot
Q9NYX1
resolver
uniprot_entry
A0A0A0MR51_HUMAN
resolver
uniprot_entry
FADS1_HUMAN
resolver
uniprot_sec
A8K0I7
resolver
uniprot_sec
B2RAI0
resolver
uniprot_sec
Q53GM5
resolver
uniprot_sec
Q8N3A6
resolver
uniprot_sec
Q8NCC7
resolver
uniprot_sec
Q8NCG0
resolver
uniprot_sec
Q96I39
resolver
uniprot_sec
Q96SV3
resolver
uniprot_sec
Q96T10
resolver
uniprot_sec
Q9NRP8
resolver
uniprot_sec
Q9NYX1
resolver
amino_acid_sequence
MAPDPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVISHYAGQDATDPFVAFHINKGLVKKYMNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVERMGLMKANHVFFLLYLLHILLLDGAAWLTLWVFGTSFLPFLLCAVLLSAVQAQAGWLQHDFGHLSVFSTSKWNHLLHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPFFFALGKILSVELGKQKKKYMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVIQRKKWVDLAWMITFYVRFFLTYVPLLGLKAFLGLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNMDWVSTQLQATCNVHKSAFNDWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKHGIEYQSKPLLSAFADIIHSLKESGQLWLDAYLHQ
uniprot
proteins
ec_number
1.14.19.44
uniprot
proteins
function
FUNCTION: [Isoform 1]: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (PubMed:10601301, PubMed:10769175). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity). {ECO:0000250|UniProtKB:Q920L1, ECO:0000250|UniProtKB:Q920R3, ECO:0000269|PubMed:10601301, ECO:0000269|PubMed:10769175}.; FUNCTION: [Isoform 2]: Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity. {ECO:0000250|UniProtKB:A4UVI1}.
uniprot
proteins
mass_dalton
51964
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis.
uniprot
proteins
protein_family
Fatty acid desaturase type 1 family
uniprot
proteins
pubmed
10601301
uniprot
proteins
pubmed
10769175
uniprot
proteins
pubmed
10860662
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
22619218
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25732826
uniprot
proteins
sequence_length
444
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A4UVI1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A4UVI1}. Mitochondrion {ECO:0000269|PubMed:22619218}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A4UVI1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A4UVI1}.
uniprot
proteins
transmembrane_region
TRANSMEM 122..142; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..170; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 268..288; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 306..326; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins