D3Z6Q9
uniprot
D3Z6Q9
canonical
amino_acid_sequence
MAEGKAGGAAGLFAKQMQKKFSRAQEKVLQKLGKTVETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSAVKVMHESSKRVSETLQEVYSSDWDGHEDLKAIVGNNDLLWEDYEEKLADQALRTMENYVSQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDDAKMAKAEEDFSKAQIVFEDLNQELLEELPILYNSRIGCYVTVFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVQSCAASSPVSPVSPVSPVTSPTSPSATSEPESVSATGEELTSEAGGEDSCESQESLKDEEADEAQSETSSSLPACNGPTPAPASPAAEVGSQEEALSSSAQSPGRGQTGKDTPSPGDVVLRARASSEGAEQSKRAASIQRTSAPPSRPPPPRASGSGSCNAPGSPEGSSQLCSPRASPDASSNPEPAETREKEGAGSSGPEEPRAVSTKSATQASGGLVGLFL
uniprot
proteins
function
FUNCTION: Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Inhibits phagocytosis (By similarity). Plays a role in podosome formation. {ECO:0000250, ECO:0000269|PubMed:23285027}.
uniprot
proteins
mass_dalton
52554
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23285027
uniprot
proteins
sequence_length
489
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UBW5}. Cell projection, podosome membrane {ECO:0000269|PubMed:23285027}; Peripheral membrane protein {ECO:0000269|PubMed:23285027}; Cytoplasmic side {ECO:0000269|PubMed:23285027}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9UBW5}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q9UBW5}. Note=Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure. {ECO:0000250|UniProtKB:Q9UBW5}.
uniprot
proteins