HACL1
entrez
26061
canonical
uniprot
Q9UJ83
canonical
ensembl
ENSG00000131373
resolver
ensp
ENSP00000323811
resolver
ensp
ENSP00000390699
resolver
ensp
ENSP00000403656
resolver
ensp
ENSP00000404883
resolver
genesymbol
HACL1
resolver
genesymbol_syn
HPCL
resolver
genesymbol_syn
HPCL2
resolver
genesymbol_syn
PHYH2
resolver
hgnc
HGNC:17856
resolver
uniprot
B4DWI1
resolver
uniprot
B4DXI5
resolver
uniprot
B4DXR1
resolver
uniprot
E9PEN4
resolver
uniprot
Q9BV42
resolver
uniprot
Q9P0A2
resolver
uniprot_entry
B4DXR1_HUMAN
resolver
uniprot_entry
HACL1_HUMAN
resolver
uniprot_sec
B4DWI1
resolver
uniprot_sec
B4DXI5
resolver
uniprot_sec
E9PEN4
resolver
uniprot_sec
Q9BV42
resolver
uniprot_sec
Q9P0A2
resolver
amino_acid_sequence
MPDSNFAERSEEQVSGAKVIAQALKTQDVEYIFGIVGIPVTEIAIAAQQLGIKYIGMRNEQAACYAASAIGYLTSRPGVCLVVSGPGLIHALGGMANANMNCWPLLVIGGSSERNQETMGAFQEFPQVEACRLYTKFSARPSSIEAIPFVIEKAVRSSIYGRPGACYVDIPADFVNLQVNVNSIKYMERCMSPPISMAETSAVCTAASVIRNAKQPLLIIGKGAAYAHAEESIKKLVEQYKLPFLPTPMGKGVVPDNHPYCVGAARSRALQFADVIVLFGARLNWILHFGLPPRYQPDVKFIQVDICAEELGNNVKPAVTLLGNIHAVTKQLLEELDKTPWQYPPESKWWKTLREKMKSNEAASKELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAVVPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTTKPSLINIMIEPQATRKAQDFHWLTRSNM
uniprot
proteins
ec_number
4.1.2.63
uniprot
proteins
function
FUNCTION: Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (PubMed:10468558, PubMed:21708296, PubMed:28289220). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (PubMed:10468558, PubMed:21708296, PubMed:28289220). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity). {ECO:0000250|UniProtKB:Q9QXE0, ECO:0000269|PubMed:10468558, ECO:0000269|PubMed:21708296, ECO:0000269|PubMed:28289220}.
uniprot
proteins
mass_dalton
63729
uniprot
proteins
mutagenesis
MUTAGEN 455; /note="D->S,R: Does not affect subcellular localization. Abolishes lyase activity. Does not affect subcellular localization, abolishes lyase activity, does not affect oligomerization and does not bind TTP; when associated with S-456."; /evidence="ECO:0000269|PubMed:21708296"; MUTAGEN 456; /note="S->R: Does not affect subcellular localization. Abolishes lyase activity. Does not affect subcellular localization, abolishes lyase activity, does not affect oligomerization and does not bind TTP; when associated with S-455."; /evidence="ECO:0000269|PubMed:21708296
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism.
uniprot
proteins
protein_family
TPP enzyme family
uniprot
proteins
pubmed
10468558
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21708296
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28289220
uniprot
proteins
sequence_length
578
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:10468558, ECO:0000269|PubMed:21708296, ECO:0000269|PubMed:28289220}.
uniprot
proteins