Nr5a2
entrez
26424
canonical
uniprot
P45448
canonical
ensembl
ENSMUSG00000026398
resolver
ensp
ENSMUSP00000027649
resolver
ensp
ENSMUSP00000129071
resolver
ensp
ENSMUSP00000141495
resolver
ensp
ENSMUSP00000142219
resolver
enst
ENSMUST00000027649
resolver
enst
ENSMUST00000168126
resolver
enst
ENSMUST00000192357
resolver
enst
ENSMUST00000192929
resolver
genesymbol
Nr5a2
resolver
genesymbol_syn
Ftf
resolver
genesymbol_syn
Lrh1
resolver
uniprot
A0A0A6YY04
resolver
uniprot
B9EHF9
resolver
uniprot
F6Z483
resolver
uniprot
Q1WLP7
resolver
uniprot_entry
A0A0A6YY04_MOUSE
resolver
uniprot_entry
F6Z483_MOUSE
resolver
uniprot_entry
NR5A2_MOUSE
resolver
uniprot_entry
Q1WLP7_MOUSE
resolver
uniprot_sec
B9EHF9
resolver
amino_acid_sequence
MSASLDTGDFQEFLKHGLTAIASAPGSETRHSPKREEQLREKRAGLPDRHRRPIPARSRLVMLPKVETEAPGLVRSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNQKRYTCIENQNCQIDKTQRKRCPYCRFKKCIDVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTSAIQNIHSASKGLPLSHVALPPTDYDRSPFVTSPISMTMPPHSSLHGYQPYGHFPSRAIKSEYPDPYSSSPESMMGYSYMDGYQTNSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQSNRNRQEKLSAFGLLCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVAHGKEGTIFLVTGEHVDYSTIISHTEVAFNNLLSLAQELVVRLRSLQFDQREFVCLKFLVLFSSDVKNLENLQLVEGVQEQVNAALLDYTVCNYPQQTEKFGQLLLRLPEIRAISKQAEDYLYYKHVNGDVPYNNLLIEMLHAKRA
uniprot
proteins
function
FUNCTION: Orphan nuclear receptor that binds DNA as a monomer to the 5'-TCAAGGCCA-3' sequence and controls expression of target genes: regulates key biological processes, such as early embryonic development, cholesterol and bile acid synthesis pathways, as well as liver and pancreas morphogenesis (PubMed:14766742, PubMed:15831456, PubMed:15976031, PubMed:29443959, PubMed:38409506, PubMed:38977846, PubMed:39361745). Ligand-binding causes conformational change which causes recruitment of coactivators, promoting target gene activation (PubMed:15976031). The specific ligand is unknown, but specific phospholipids, such as phosphatidylethanolamine, phosphatidylserine, dilauroyl phosphatidylcholine and diundecanoyl phosphatidylcholine can act as ligand in vitro (PubMed:15976031). Acts as a pioneer transcription factor, which unwraps target DNA from histones and elicits local opening of closed chromatin (PubMed:38409506). Plays a central role during preimplantation stages of embryonic development (PubMed:15014077, PubMed:15831456, PubMed:34397088, PubMed:36423263, PubMed:37935903, PubMed:38243114, PubMed:38386558, PubMed:39361745). Plays a minor role in zygotic genome activation (ZGA) by regulating a small set of two-cell stage genes (PubMed:36423263, PubMed:39361745). Plays a major role in morula development (2-16 cells embryos) by acting as a master regulator at the 8-cell stage, controlling expression of lineage-specifying transcription factors and genes involved in mitosis, telomere maintenance and DNA repair (PubMed:37935903, PubMed:38386558, PubMed:39361745). Zygotic NR5A2 binds to both closed and open chromatin with other transcription factors, often at SINE B1/Alu repeats DNA elements, promoting chromatin accessibility at nearby regulatory regions (PubMed:39361745). Also involved in the epiblast stage of development and embryonic stem cell pluripotency, by promoting expression of POU5F1/OCT4 (PubMed:15831456, PubMed:20096661, PubMed:27984042, PubMed:34397088, PubMed:38386558). Regulates other processes later in development, such as formation of connective tissue in lower jaw and middle ear, neural stem cell differentiation, ovarian follicle development and Sertoli cell differentiation (PubMed:27447294, PubMed:33441767, PubMed:35192609, PubMed:36905926). Involved in exocrine pancreas development and acinar cell differentiation (PubMed:21852532, PubMed:25063451, PubMed:29443959). Acts as an essential transcriptional regulator of lipid metabolism (By similarity). Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver (By similarity). Activates the transcription of CYP2C38 (PubMed:30555544). Also acts as a negative regulator of inflammation in different organs, such as intestine, liver and pancreas (PubMed:17670946, PubMed:29443959, PubMed:30305617). Protects against intestinal inflammation via its ability to regulate glucocorticoid production (PubMed:16923850, PubMed:17670946). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity). Acts as a regulator of immunity by promoting lymphocyte T-cell development, proliferation and effector functions (PubMed:31328159). Also involved in resolution of endoplasmic reticulum stress in the liver (PubMed:24737860). {ECO:0000250|UniProtKB:O00482, ECO:0000269|PubMed:14766742, ECO:0000269|PubMed:15014077, ECO:0000269|PubMed:15831456, ECO:0000269|PubMed:15976031, ECO:0000269|PubMed:16923850, ECO:0000269|PubMed:17670946, ECO:0000269|PubMed:20096661, ECO:0000269|PubMed:21852532, ECO:0000269|PubMed:24737860, ECO:0000269|PubMed:25063451, ECO:0000269|PubMed:27447294, ECO:0000269|PubMed:27984042, ECO:0000269|PubMed:29443959, ECO:0000269|PubMed:30305617, ECO:0000269|PubMed:30555544, ECO:0000269|PubMed:31328159, ECO:0000269|PubMed:33441767, ECO:0000269|PubMed:34397088, ECO:0000269|PubMed:35192609, ECO:0000269|PubMed:36423263, ECO:0000269|PubMed:36905926, ECO:0000269|PubMed:37935903, ECO:0000269|PubMed:38243114, ECO:0000269|PubMed:38386558, ECO:0000269|PubMed:38409506, ECO:0000269|PubMed:38977846, ECO:0000269|PubMed:39361745}.
uniprot
proteins
mass_dalton
64020
uniprot
proteins
mutagenesis
MUTAGEN 173; /note="K->R: Does not affect early embryonic development; when associated with R-289."; /evidence="ECO:0000269|PubMed:38386558"; MUTAGEN 180; /note="D->A: Strongly reduced nucleosome-binding."; /evidence="ECO:0000269|PubMed:38409506"; MUTAGEN 289; /note="K->R: Does not affect early embryonic development; when associated with R-173."; /evidence="ECO:0000269|PubMed:38386558
uniprot
proteins
post_translational_modification
PTM: Sumoylated by SUMO1 at Lys-289 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation. {ECO:0000250|UniProtKB:O00482}.
uniprot
proteins
protein_family
NR5 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
12820970
uniprot
proteins
pubmed
14766742
uniprot
proteins
pubmed
15014077
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15831456
uniprot
proteins
pubmed
15976031
uniprot
proteins
pubmed
16923850
uniprot
proteins
pubmed
17670946
uniprot
proteins
pubmed
19015525
uniprot
proteins
pubmed
20096661
uniprot
proteins
pubmed
21614002
uniprot
proteins
pubmed
21852532
uniprot
proteins
pubmed
24737860
uniprot
proteins
pubmed
25063451
uniprot
proteins
pubmed
27447294
uniprot
proteins
pubmed
27984042
uniprot
proteins
pubmed
29443959
uniprot
proteins
pubmed
30305617
uniprot
proteins
pubmed
30555544
uniprot
proteins
pubmed
31328159
uniprot
proteins
pubmed
33441767
uniprot
proteins
pubmed
34397088
uniprot
proteins
pubmed
35192609
uniprot
proteins
pubmed
36423263
uniprot
proteins
pubmed
36905926
uniprot
proteins
pubmed
37935903
uniprot
proteins
pubmed
38243114
uniprot
proteins
pubmed
38386558
uniprot
proteins
pubmed
38409506
uniprot
proteins
pubmed
38977846
uniprot
proteins
pubmed
39361745
uniprot
proteins
sequence_length
560
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33441767, ECO:0000269|PubMed:36423263}. Chromosome {ECO:0000269|PubMed:15014077}.
uniprot
proteins