Taf5l
entrez
102162
canonical
uniprot
Q91WQ5
canonical
ensembl
ENSMUSG00000038697
resolver
ensp
ENSMUSP00000090726
resolver
ensp
ENSMUSP00000128710
resolver
enst
ENSMUST00000093039
resolver
enst
ENSMUST00000165628
resolver
genesymbol
Taf5l
resolver
genesymbol_syn
Paf65b
resolver
uniprot
Q8BTL5
resolver
uniprot_entry
TAF5L_MOUSE
resolver
uniprot_sec
Q8BTL5
resolver
amino_acid_sequence
MKRVRTEQVQVAVSCYLKRRQYVDSEGPLKQGLRLSQTPEEMAANLTVQSESGCANAVSAAPCQAEPQQYEVQFGRLRSFLTDSDSQYSREVMPLLYPLFVYLHLNLVQSGPKSTVESFYSRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFQLRAFLDNKYVVRLQEDSYNYLIRYLQSDNNTALCKVLAVHIHLDVQPAKRTDYQLYASGGSSRTENSSLEPPEVPSPILQNEAALEVLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISSDSKLLAAGFDNSCIKLWSLRSKKLKSEPHHVDTSRIRLACDTLEEEENEEDNTGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDVDISPFSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLSFSPNGKYLASAGEDQRLKLWDLASGTLFKELRGHTDSITSLAFSPDSGLIASASMDNSVRVWDIRSTCCNTPADGSSGELVGVYTGQMSNVLSVQFMACNLLLVTGITQENQEH
uniprot
proteins
function
FUNCTION: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (By similarity). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (PubMed:31005419). {ECO:0000250|UniProtKB:O75529, ECO:0000269|PubMed:31005419}.
uniprot
proteins
mass_dalton
65911
uniprot
proteins
protein_family
WD repeat TAF5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
31005419
uniprot
proteins
sequence_length
589
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31005419}.
uniprot
proteins