KLK11
entrez
11012
canonical
uniprot
Q9UBX7
canonical
ensembl
ENSG00000167757
resolver
ensp
ENSP00000324269
resolver
ensp
ENSP00000375680
resolver
ensp
ENSP00000413958
resolver
ensp
ENSP00000473047
resolver
genesymbol
KLK11
resolver
genesymbol_syn
PRSS20
resolver
genesymbol_syn
TLSP
resolver
hgnc
HGNC:6359
resolver
uniprot
O75837
resolver
uniprot
Q0WXX5
resolver
uniprot
Q8IXD7
resolver
uniprot
Q9NS65
resolver
uniprot_entry
KLK11_HUMAN
resolver
uniprot_sec
O75837
resolver
uniprot_sec
Q0WXX5
resolver
uniprot_sec
Q8IXD7
resolver
uniprot_sec
Q9NS65
resolver
amino_acid_sequence
MQRLRWLRDWKSSGRGLTAAKEPGARSSPLQAMRILQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTAAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENAYPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVYTKVCKYVDWIQETMKNN
uniprot
proteins
disease_involvement
DISEASE: Ichthyosis with erythrokeratoderma (IEKD) [MIM:620507]: An autosomal dominant genodermatosis characterized by early-onset ichthyosiform erythroderma with excessive skin scaling and peeling, and erythematous hyperkeratotic plaques. Lesions are present at birth or appear soon after. {ECO:0000269|PubMed:36689511, ECO:0000269|PubMed:37212630}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. {ECO:0000269|PubMed:10872828, ECO:0000269|PubMed:16467084}.
uniprot
proteins
mass_dalton
31059
uniprot
proteins
post_translational_modification
PTM: About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen. {ECO:0000269|PubMed:16467084}.
uniprot
proteins
protein_family
Kallikrein subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10662548
uniprot
proteins
pubmed
10872828
uniprot
proteins
pubmed
11054574
uniprot
proteins
pubmed
12539228
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16467084
uniprot
proteins
pubmed
16911518
uniprot
proteins
pubmed
36689511
uniprot
proteins
pubmed
37212630
uniprot
proteins
pubmed
9765601
uniprot
proteins
sequence_length
282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Secreted.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus {ECO:0000269|PubMed:36689511}. Secreted {ECO:0000269|PubMed:36689511}.
uniprot
proteins