Capn3
entrez
12335
canonical
uniprot
Q64691
canonical
ensembl
ENSMUSG00000079110
resolver
ensp
ENSMUSP00000028748
resolver
ensp
ENSMUSP00000028749
resolver
ensp
ENSMUSP00000106349
resolver
enst
ENSMUST00000028748
resolver
genesymbol
Capn3
resolver
uniprot
A2AVV3
resolver
uniprot
A4QPE6
resolver
uniprot
F6SVN5
resolver
uniprot
Q0VGP9
resolver
uniprot
Q9WUC5
resolver
uniprot_entry
A4QPE6_MOUSE
resolver
uniprot_entry
CAN3_MOUSE
resolver
uniprot_entry
F6SVN5_MOUSE
resolver
uniprot_entry
Q0VGP9_MOUSE
resolver
uniprot_sec
A2AVV3
resolver
uniprot_sec
Q9WUC5
resolver
activity_regulation
ACTIVITY REGULATION: Activated by micromolar concentrations of calcium and inhibited by calpastatin.
uniprot
proteins
amino_acid_sequence
MPTVISPTVAPRTGAEPRSPGPVPHPAQGKTTEAGGGHPSGIYSAIISRNFPIIGVKEKTFEQLRRKCLEKKVLYLDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIGGANRTDICQGDLGDCWFLAAIACLTLNERLLFRVIPHDQSFTENYAGIFHFQFWRYGDWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIKDAPSDMYKIMRKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLRDSDLDPRGSDDRPSRTIVPVQYETRMACGLVKGHAYSVTGLEEALFKGEKVKLVRLRNPWGQVEWNGSWSDGWKDWSFVDKDEKARLQHQVTEDGEFWMSYDDFVYHFTKLEICNLTADALESDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPEDSEVICSFLVALMQKNRRKDRKLGANLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEAENTISVDRPVKKKKNKPIIFVSDRANSNKELGVDQEAEEGKDKAGPEKRGETPQPRPGHTDQESEEQQQFRNIFRQIAGDDMEICADELKNVLNTVVNKHKDLKTQGFTLESCRSMIALMDTDGSGRLNLQEFHHLWKKIKAWQKIFKHYDTDHSGTINSYEMRNAVNDAGFHLNSQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFNAFDKDGDGIIKLNVLEWLQLTMYA
uniprot
proteins
ec_number
3.4.22.54
uniprot
proteins
function
FUNCTION: Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-410'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53. {ECO:0000250|UniProtKB:P20807}.
uniprot
proteins
mass_dalton
94242
uniprot
proteins
protein_family
Peptidase C2 family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8661728
uniprot
proteins
sequence_length
821
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P20807}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P20807}.
uniprot
proteins