SAA1
entrez
6288
canonical
uniprot
P0DJI8
canonical
ensembl
ENSG00000173432
resolver
ensembl
ENSG00000288411
resolver
ensp
ENSP00000348918
resolver
ensp
ENSP00000384906
resolver
ensp
ENSP00000436866
resolver
ensp
ENSP00000500281
resolver
ensp
ENSP00000500630
resolver
ensp
ENSP00000500639
resolver
enst
ENST00000356524
resolver
enst
ENST00000405158
resolver
enst
ENST00000532858
resolver
enst
ENST00000672418
resolver
enst
ENST00000672662
resolver
enst
ENST00000672712
resolver
genesymbol
SAA1
resolver
hgnc
HGNC:10513
resolver
uniprot
E9PQD6
resolver
uniprot
P02735
resolver
uniprot
P02736
resolver
uniprot
P02737
resolver
uniprot
Q16730
resolver
uniprot
Q16834
resolver
uniprot
Q16835
resolver
uniprot
Q16879
resolver
uniprot
Q3KRB3
resolver
uniprot
Q6FG67
resolver
uniprot
Q96QN0
resolver
uniprot
Q9UCK9
resolver
uniprot
Q9UCL0
resolver
uniprot_entry
SAA1_HUMAN
resolver
uniprot_sec
E9PQD6
resolver
uniprot_sec
P02735
resolver
uniprot_sec
P02736
resolver
uniprot_sec
P02737
resolver
uniprot_sec
Q16730
resolver
uniprot_sec
Q16834
resolver
uniprot_sec
Q16835
resolver
uniprot_sec
Q16879
resolver
uniprot_sec
Q3KRB3
resolver
uniprot_sec
Q6FG67
resolver
uniprot_sec
Q96QN0
resolver
uniprot_sec
Q9UCK9
resolver
uniprot_sec
Q9UCL0
resolver
amino_acid_sequence
MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGAWAAEVITDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY
uniprot
proteins
disease_involvement
DISEASE: Note=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. {ECO:0000269|PubMed:1463770}.; DISEASE: Note=Elevated serum SAA1 protein levels may be associated with lung cancer. {ECO:0000269|PubMed:1463770}.
uniprot
proteins
function
FUNCTION: Major acute phase protein.
uniprot
proteins
mass_dalton
13546
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="R->A: Reduces affinity for heparin and nearly abolishes association with HDL; when associated with A-80 and A-89."; /evidence="ECO:0000269|PubMed:24706838"; MUTAGEN 33; /note="R->A: Reduces affinity for heparin; when associated with A-37 and A-65."; /evidence="ECO:0000269|PubMed:24706838"; MUTAGEN 37; /note="R->A: Reduces affinity for heparin; when associated with A-33 and A-65."; /evidence="ECO:0000269|PubMed:24706838"; MUTAGEN 65; /note="R->A: Reduces affinity for heparin; when associated with A-33 and A-37."; /evidence="ECO:0000269|PubMed:24706838"; MUTAGEN 80; /note="R->A: Reduces affinity for heparin and nearly abolishes association with HDL; when associated with A-18 and A-89."; /evidence="ECO:0000269|PubMed:24706838"; MUTAGEN 89; /note="H->A: Reduces affinity for heparin and nearly abolishes association with HDL; when associated with A-18 and A-80."; /evidence="ECO:0000269|PubMed:24706838
uniprot
proteins
post_translational_modification
PTM: This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.
uniprot
proteins
protein_family
SAA family
uniprot
proteins
pubmed
10211414
uniprot
proteins
pubmed
11946204
uniprot
proteins
pubmed
1259755
uniprot
proteins
pubmed
12606051
uniprot
proteins
pubmed
12973732
uniprot
proteins
pubmed
1463770
uniprot
proteins
pubmed
1546977
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
1656519
uniprot
proteins
pubmed
1971508
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24706838
uniprot
proteins
pubmed
3183061
uniprot
proteins
pubmed
3442653
uniprot
proteins
pubmed
3839415
uniprot
proteins
pubmed
4816450
uniprot
proteins
pubmed
5055786
uniprot
proteins
pubmed
5056669
uniprot
proteins
pubmed
6155694
uniprot
proteins
pubmed
7115671
uniprot
proteins
pubmed
8512321
uniprot
proteins
pubmed
8670280
uniprot
proteins
pubmed
8783012
uniprot
proteins
sequence_length
122
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7115671}.
uniprot
proteins