Isy1
entrez
57905
canonical
uniprot
Q69ZQ2
canonical
ensembl
ENSMUSG00000030056
resolver
ensp
ENSMUSP00000086923
resolver
enst
ENSMUST00000089497
resolver
genesymbol
Isy1
resolver
genesymbol_syn
Kiaa1160
resolver
uniprot
Q8VDX4
resolver
uniprot
Q9D3E2
resolver
uniprot_entry
ISY1_MOUSE
resolver
uniprot_sec
Q8VDX4
resolver
uniprot_sec
Q9D3E2
resolver
amino_acid_sequence
MARNAEKAMTALARFRQAQLEEGKVKERRPFLASECTELPKAEKWRRQIIGEISKKVAQIQNAGLGEFRIRDLNDEINKLLREKGHWEVRIKELGGPDYGKVGPKMLDHEGKEVPGNRGYKYFGAAKDLPGVRELFEKEPLPPPRKTRAELMKAIDFEYYGYLDEDDGVIVPLEQEYEKKLRAELVEKWKAEREARLARGEKEEEEEEEEEINIYAVTEEESDEEGNQEKAGEDGQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSEEAKRLLGY
uniprot
proteins
function
FUNCTION: Component of the spliceosome C complex required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation (PubMed:26255770, PubMed:29804889). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (PubMed:26255770). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (PubMed:29804889). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (PubMed:29804889). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes the transition to the primed state (PubMed:29804889). Involved in pre-mRNA splicing as component of the spliceosome. {ECO:0000250|UniProtKB:Q9ULR0, ECO:0000269|PubMed:26255770, ECO:0000269|PubMed:29804889}.
uniprot
proteins
mass_dalton
32989
uniprot
proteins
protein_family
ISY1 family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26255770
uniprot
proteins
pubmed
29804889
uniprot
proteins
sequence_length
285
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9ULR0}.
uniprot
proteins