Q60825
uniprot
Q60825
canonical
amino_acid_sequence
MMSYSERLGGPAVSPLPVRGRHMVHGATFAYVPSPQVLHRIPGTSTYAISSLSPVTLTEHSCPCGEVLECHDPLPTKLAQEEEQKPEPRLSQKLAQVGTKLLKVPLMLAFLYLFVCSLDVLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHVTGLVVASFNIRGGRDAPDLLKVITEPFTRLIIQLDKSVITSIAVGDESLRNHSLIRIWCHPDTTEASTSMSRVEAIGSLANTTMEKCNHIFVDTGLPDLAVGLILLAGSLVVLCTCLILLVKMLNSLLKGQVMSSRRSSTQTDFPAPFTWVTGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSSFQIALCHFFFNISGILLWYPLPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQAMVGVGTPFGALLAFVVLVNVLQSRSPGHLPKWLQTWDFLPRWMHSLQPLDGLITRATLCYARPEPRSPQLPPRVFLEELPPATPSPRLALPAHHNATRL
uniprot
proteins
function
FUNCTION: Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:7478940, PubMed:8070635). The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (By similarity). {ECO:0000250|UniProtKB:Q06496, ECO:0000269|PubMed:7478940, ECO:0000269|PubMed:8070635}.
uniprot
proteins
mass_dalton
68774
uniprot
proteins
protein_family
SLC34A transporter family
uniprot
proteins
pubmed
10497181
uniprot
proteins
pubmed
11950846
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
35428804
uniprot
proteins
pubmed
35459732
uniprot
proteins
pubmed
7478940
uniprot
proteins
pubmed
8070635
uniprot
proteins
pubmed
8693007
uniprot
proteins
sequence_length
637
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:35428804}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q06496}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of the proximal tubules. Internalized from the cell surface upon PTH stimulation (PubMed:35428804). {ECO:0000250|UniProtKB:Q06496, ECO:0000269|PubMed:35428804}.
uniprot
proteins
transmembrane_region
TRANSMEM 104..125; /note="Helical; Name=M1"; /evidence="ECO:0000255"; TRANSMEM 146..163; /note="Helical; Name=M2"; /evidence="ECO:0000255"; TRANSMEM 166..185; /note="Helical; Name=M3"; /evidence="ECO:0000255"; TRANSMEM 346..368; /note="Helical; Name=M4"; /evidence="ECO:0000255"; TRANSMEM 411..434; /note="Helical; Name=M5"; /evidence="ECO:0000255"; TRANSMEM 465..485; /note="Helical; Name=M6"; /evidence="ECO:0000255"; TRANSMEM 512..532; /note="Helical; Name=M7"; /evidence="ECO:0000255"; TRANSMEM 538..559; /note="Helical; Name=M8"; /evidence="ECO:0000255
uniprot
proteins