Kirrel3
entrez
67703
canonical
uniprot
Q8BR86
canonical
ensembl
ENSMUSG00000032036
resolver
ensp
ENSMUSP00000048863
resolver
ensp
ENSMUSP00000110801
resolver
ensp
ENSMUSP00000139418
resolver
ensp
ENSMUSP00000139714
resolver
ensp
ENSMUSP00000139951
resolver
ensp
ENSMUSP00000140219
resolver
ensp
ENSMUSP00000263315
resolver
ensp
ENSMUSP00000263317
resolver
ensp
ENSMUSP00000263318
resolver
enst
ENSMUST00000045091
resolver
enst
ENSMUST00000187625
resolver
enst
ENSMUST00000188933
resolver
genesymbol
Kirrel3
resolver
genesymbol_syn
Kiaa1867
resolver
genesymbol_syn
Neph2
resolver
uniprot
A0A087WNM9
resolver
uniprot
G5E8B6
resolver
uniprot
Q6P555
resolver
uniprot
Q810H3
resolver
uniprot
Q8BGQ5
resolver
uniprot
Q8BRS8
resolver
uniprot_entry
A0A087WNM9_MOUSE
resolver
uniprot_entry
G5E8B6_MOUSE
resolver
uniprot_entry
KIRR3_MOUSE
resolver
uniprot_sec
Q6P555
resolver
uniprot_sec
Q810H3
resolver
uniprot_sec
Q8BGQ5
resolver
uniprot_sec
Q8BRS8
resolver
amino_acid_sequence
MRPFQLDLLFLCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPIILGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNIVTFHCSAKANPAVTQYRWAKRGHIIKEASGELYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTSEPQSLLVDLGSDAVFSCAWIGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETVNTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPSSGREAEDHTTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPDLRPTGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV
uniprot
proteins
function
FUNCTION: Synaptic adhesion molecule required for the formation of target-specific synapses (PubMed:23637329, PubMed:26575286). Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation (PubMed:26575286). Required for the coalescence of vomeronasal sensory neuron axons (PubMed:23637329). May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells (PubMed:12665856). {ECO:0000269|PubMed:12665856, ECO:0000269|PubMed:23637329, ECO:0000269|PubMed:26575286}.
uniprot
proteins
mass_dalton
85405
uniprot
proteins
post_translational_modification
PTM: Undergoes proteolysis by a metalloprotease and gives rise to a soluble form. {ECO:0000269|PubMed:12665856, ECO:0000269|PubMed:15843475}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
12665856
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15843475
uniprot
proteins
pubmed
15908127
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18752272
uniprot
proteins
pubmed
21241806
uniprot
proteins
pubmed
23637329
uniprot
proteins
pubmed
26283919
uniprot
proteins
pubmed
26575286
uniprot
proteins
sequence_length
778
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12665856}; Single-pass type I membrane protein {ECO:0000269|PubMed:12665856}. Cell projection, axon {ECO:0000269|PubMed:26575286}. Cell projection, dendrite {ECO:0000269|PubMed:26575286}.; SUBCELLULAR LOCATION: [Processed kin of IRRE-like protein 3]: Secreted {ECO:0000269|PubMed:12665856}.
uniprot
proteins
transmembrane_region
TRANSMEM 536..556; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins