Gdf6
entrez
242316
canonical
uniprot
P43028
canonical
ensembl
ENSMUSG00000051279
resolver
ensp
ENSMUSP00000062884
resolver
enst
ENSMUST00000057613
resolver
genesymbol
Gdf6
resolver
genesymbol_syn
Bmp13
resolver
genesymbol_syn
Gdf-6
resolver
genesymbol_syn
Gdf16
resolver
uniprot
A2AII0
resolver
uniprot
Q70UT4
resolver
uniprot_entry
A2AII0_MOUSE
resolver
uniprot_entry
GDF6_MOUSE
resolver
uniprot_sec
Q70UT4
resolver
amino_acid_sequence
MDTPRVLLWAIFLISFLWDLPGFQQASISSSSSSSTELDSTKDVGNRKEGKMQRTPQESAEGRTPPEHGLRQKDLRRRPPGQHQGQEPPGRGLRVVPHEYMLSIYKTYSIAEKLGINASFFQSSKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSTLSDKEELVGAELRLYRQAPPTPWGLPARPLHLQLFPCLSPLLLDARTLDPQGPTQAGWEVFDVWQGLRPQPWKQLCLELRAAWGELDAGDTGARARGPQQPPPLDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFTEMHEQLGSAEAAGAEGSWPAPSGSPDAGSWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSRKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR
uniprot
proteins
function
FUNCTION: Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures (PubMed:26774823). Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:12606286, PubMed:16049014). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (PubMed:23527555). {ECO:0000269|PubMed:12606286, ECO:0000269|PubMed:16049014, ECO:0000269|PubMed:23307924, ECO:0000269|PubMed:23527555, ECO:0000269|PubMed:26774823}.
uniprot
proteins
mass_dalton
50942
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
12606286
uniprot
proteins
pubmed
16049014
uniprot
proteins
pubmed
23307924
uniprot
proteins
pubmed
23527555
uniprot
proteins
pubmed
24076600
uniprot
proteins
pubmed
26774823
uniprot
proteins
pubmed
32369452
uniprot
proteins
pubmed
8145850
uniprot
proteins
sequence_length
454
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6KF10}.
uniprot
proteins