Gna11
entrez
14672
canonical
uniprot
P21278
canonical
ensembl
ENSMUSG00000034781
resolver
ensp
ENSMUSP00000043190
resolver
enst
ENSMUST00000043604
resolver
genesymbol
Gna11
resolver
genesymbol_syn
Gna-11
resolver
uniprot
Q3UPA1
resolver
uniprot
Q61939
resolver
uniprot_entry
GNA11_MOUSE
resolver
uniprot_entry
Q3UPA1_MOUSE
resolver
uniprot_sec
Q61939
resolver
amino_acid_sequence
MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAMVRAMETLKILYKYEQNKANALLIREVDVEKVTTFEHQYVNAIKTLWSDPGVQECYDRRREFQLSDSAKYYLTDVDRIATVGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILHSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:9687499). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:9687499). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:9687499). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:9687499). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:9687499). Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNA11 activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:9687499). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity). Together with GNAQ, required for heart development (PubMed:9687499). In the respiratory epithelium, transmits OXGR1-dependent signals that lead to downstream intracellular Ca(2+) release and mucocilliary clearance of airborne pathogens. {ECO:0000250|UniProtKB:P29992, ECO:0000269|PubMed:9687499}.
uniprot
proteins
mass_dalton
42024
uniprot
proteins
protein_family
G(q) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2123549
uniprot
proteins
pubmed
2508088
uniprot
proteins
pubmed
8838318
uniprot
proteins
pubmed
9687499
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P29992}; Lipid-anchor {ECO:0000250|UniProtKB:P29992}. Cytoplasm {ECO:0000250|UniProtKB:P29992}.
uniprot
proteins