COMT
entrez
1312
canonical
uniprot
P21964
canonical
ensembl
ENSG00000093010
resolver
ensp
ENSP00000354511
resolver
ensp
ENSP00000385150
resolver
ensp
ENSP00000385917
resolver
ensp
ENSP00000403958
resolver
ensp
ENSP00000416778
resolver
genesymbol
COMT
resolver
hgnc
HGNC:2228
resolver
uniprot
A0A140VJG8
resolver
uniprot
A8MPV9
resolver
uniprot
Q6IB07
resolver
uniprot
Q6ICE6
resolver
uniprot
Q9BWC7
resolver
uniprot_entry
A0A140VJG8_HUMAN
resolver
uniprot_entry
COMT_HUMAN
resolver
uniprot_sec
A8MPV9
resolver
uniprot_sec
Q6IB07
resolver
uniprot_sec
Q6ICE6
resolver
uniprot_sec
Q9BWC7
resolver
amino_acid_sequence
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
uniprot
proteins
disease_involvement
DISEASE: Schizophrenia (SCZD) [MIM:181500]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269|PubMed:15645182}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.1.1.6
uniprot
proteins
function
FUNCTION: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. {ECO:0000269|PubMed:11559542, ECO:0000269|PubMed:21846718}.
uniprot
proteins
mass_dalton
30037
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.
uniprot
proteins
protein_family
Cation-dependent O-methyltransferase family
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
10395222
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11559542
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15645182
uniprot
proteins
pubmed
1707278
uniprot
proteins
pubmed
1765063
uniprot
proteins
pubmed
18442637
uniprot
proteins
pubmed
18474266
uniprot
proteins
pubmed
1847521
uniprot
proteins
pubmed
18486144
uniprot
proteins
pubmed
1993083
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21846718
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
8020475
uniprot
proteins
pubmed
8055944
uniprot
proteins
pubmed
8807664
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Soluble]: Cytoplasm {ECO:0000269|PubMed:11559542}.; SUBCELLULAR LOCATION: [Isoform Membrane-bound]: Cell membrane {ECO:0000269|PubMed:21846718}; Single-pass type II membrane protein {ECO:0000269|PubMed:21846718}; Extracellular side {ECO:0000269|PubMed:21846718}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..26; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins