Pln
entrez
64672
canonical
uniprot
P61016
canonical
ensembl
ENSRNOG00000079579
resolver
ensembl
ENSRNOG00055015423
resolver
ensembl
ENSRNOG00060008312
resolver
ensembl
ENSRNOG00065003418
resolver
ensp
ENSRNOP00000105613
resolver
ensp
ENSRNOP00055021395
resolver
ensp
ENSRNOP00060010516
resolver
ensp
ENSRNOP00065003430
resolver
enst
ENSRNOT00000122906
resolver
enst
ENSRNOT00055026323
resolver
enst
ENSRNOT00060013796
resolver
enst
ENSRNOT00065004859
resolver
genesymbol
Pln
resolver
uniprot
P20006
resolver
uniprot_entry
PPLA_RAT
resolver
uniprot_sec
P20006
resolver
amino_acid_sequence
MEKVQYLTRSAIRRASTIEMPQQARQNLQNLFINFCLILICLLLICIIVMLL
uniprot
proteins
function
FUNCTION: Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Binds preferentially to the ATP-bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle. Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Also inhibits the activity of ATP2A3/SERCA3. Controls intracellular Ca(2+) levels in elongated spermatids and may play a role in germ cell differentiation. In the thalamic reticular nucleus of the brain, plays a role in the regulation of sleep patterns and executive functioning. {ECO:0000250|UniProtKB:P61012, ECO:0000250|UniProtKB:P61014}.
uniprot
proteins
mass_dalton
6095
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:P26678}.; PTM: Palmitoylated by ZDHHC16, promoting formation of the homopentamer. {ECO:0000250|UniProtKB:P61014}.; PTM: In elongated spermatids, proteolytically cleaved by SPPL2C which modulates intracellular Ca(2+) homeostasis. {ECO:0000250|UniProtKB:P61014}.
uniprot
proteins
protein_family
Phospholamban family
uniprot
proteins
pubmed
1445334
uniprot
proteins
pubmed
1725098
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8508530
uniprot
proteins
sequence_length
52
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P26678}; Single-pass membrane protein {ECO:0000255}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P26678}; Single-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:A4IFH6}; Single-pass membrane protein {ECO:0000255}. Membrane {ECO:0000250|UniProtKB:P61014}; Single-pass membrane protein {ECO:0000255}. Note=Colocalizes with HAX1 at the endoplasmic reticulum. Colocalizes with DMPK at the sarcoplasmic reticulum. {ECO:0000250|UniProtKB:P26678}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins