ELOB
entrez
6923
canonical
uniprot
Q15370
canonical
ensembl
ENSG00000103363
resolver
ensp
ENSP00000262306
resolver
ensp
ENSP00000386652
resolver
genesymbol
ELOB
resolver
genesymbol_syn
TCEB2
resolver
hgnc
HGNC:11619
resolver
uniprot
A0A384MDL3
resolver
uniprot
B7WPD3
resolver
uniprot_entry
A0A384MDL3_HUMAN
resolver
uniprot_entry
ELOB_HUMAN
resolver
uniprot_sec
B7WPD3
resolver
amino_acid_sequence
MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ
uniprot
proteins
function
FUNCTION: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). {ECO:0000250|UniProtKB:P62869, ECO:0000269|PubMed:7638163}.; FUNCTION: Core component of multiple cullin-2 and cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes), which mediate the ubiquitination of target proteins (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694, PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:33268465, PubMed:37844242, PubMed:38326650, PubMed:39039081, PubMed:35512830, PubMed:39039081, PubMed:40440427, PubMed:40963025). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694). Component the von Hippel-Lindau ubiquitination complex CBC(VHL) (PubMed:10205047, PubMed:12004076, PubMed:12050673, PubMed:15590694). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:26138980, PubMed:29775578, PubMed:29779948, PubMed:36805027, PubMed:37844242, PubMed:38177675). The ECS(ASB9) complex mediates ubiquitination and degradation of CKB (PubMed:33268465). As part of a multisubunit ubiquitin ligase complex, polyubiquitinates monoubiquitinated POLR2A (PubMed:19920177). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). The ECS(ASB7) complex acts a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1 (PubMed:40440427). As part of the ECS(LRRC58) complex, mediates CDO1 ubiquitination and degradation, regulating cysteine catabolism (PubMed:40963025). {ECO:0000250|UniProtKB:P62869, ECO:0000269|PubMed:10205047, ECO:0000269|PubMed:12004076, ECO:0000269|PubMed:12050673, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:33268465, ECO:0000269|PubMed:35512830, ECO:0000269|PubMed:36805027, ECO:0000269|PubMed:37844242, ECO:0000269|PubMed:38177675, ECO:0000269|PubMed:39039081, ECO:0000269|PubMed:40440427, ECO:0000269|PubMed:40963025}.; FUNCTION: (Microbial infection) Following infection by HIV-1 virus, component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, which catalyzes ubiquitination and degradation of APOBEC3F and APOBEC3G (PubMed:18562529, PubMed:20532212, PubMed:22190037, PubMed:24225024, PubMed:24402281, PubMed:36754086). The complex can also ubiquitinate APOBEC3H to some extent (PubMed:37640699). {ECO:0000269|PubMed:18562529, ECO:0000269|PubMed:20532212, ECO:0000269|PubMed:22190037, ECO:0000269|PubMed:24225024, ECO:0000269|PubMed:24402281, ECO:0000269|PubMed:36754086, ECO:0000269|PubMed:37640699}.
uniprot
proteins
mass_dalton
13133
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:29775578, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:33268465, ECO:0000269|PubMed:37844242, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:40440427, ECO:0000269|PubMed:40963025}.
uniprot
proteins
protein_family
Elongin B family
uniprot
proteins
pubmed
10205047
uniprot
proteins
pubmed
11006129
uniprot
proteins
pubmed
12004076
uniprot
proteins
pubmed
12050673
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15574592
uniprot
proteins
pubmed
15590694
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17189197
uniprot
proteins
pubmed
17997974
uniprot
proteins
pubmed
18562529
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19920177
uniprot
proteins
pubmed
20532212
uniprot
proteins
pubmed
21119685
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21697472
uniprot
proteins
pubmed
21980433
uniprot
proteins
pubmed
22190037
uniprot
proteins
pubmed
22286099
uniprot
proteins
pubmed
22510880
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23102700
uniprot
proteins
pubmed
23837592
uniprot
proteins
pubmed
24225024
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24337577
uniprot
proteins
pubmed
24402281
uniprot
proteins
pubmed
25505247
uniprot
proteins
pubmed
26041281
uniprot
proteins
pubmed
26138980
uniprot
proteins
pubmed
26906416
uniprot
proteins
pubmed
29775578
uniprot
proteins
pubmed
29779948
uniprot
proteins
pubmed
31182716
uniprot
proteins
pubmed
31387940
uniprot
proteins
pubmed
32513959
uniprot
proteins
pubmed
33268465
uniprot
proteins
pubmed
34700328
uniprot
proteins
pubmed
34857742
uniprot
proteins
pubmed
35486881
uniprot
proteins
pubmed
35512830
uniprot
proteins
pubmed
36754086
uniprot
proteins
pubmed
36805027
uniprot
proteins
pubmed
37640699
uniprot
proteins
pubmed
37816714
uniprot
proteins
pubmed
37844242
uniprot
proteins
pubmed
38177675
uniprot
proteins
pubmed
38326650
uniprot
proteins
pubmed
38418882
uniprot
proteins
pubmed
39039081
uniprot
proteins
pubmed
39548056
uniprot
proteins
pubmed
40440427
uniprot
proteins
pubmed
40963025
uniprot
proteins
pubmed
7638163
uniprot
proteins
sequence_length
118
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:34700328}.
uniprot
proteins