MSI2
entrez
124540
canonical
uniprot
Q96DH6
canonical
ensembl
ENSG00000153944
resolver
ensp
ENSP00000284073
resolver
ensp
ENSP00000313616
resolver
ensp
ENSP00000414671
resolver
ensp
ENSP00000501836
resolver
ensp
ENSP00000660616
resolver
ensp
ENSP00000660621
resolver
enst
ENST00000416426
resolver
genesymbol
MSI2
resolver
hgnc
HGNC:18585
resolver
uniprot
B4DHE8
resolver
uniprot
F6TAI2
resolver
uniprot
Q7Z6M7
resolver
uniprot
Q8N9T4
resolver
uniprot_entry
B4DHE8_HUMAN
resolver
uniprot_entry
F6TAI2_HUMAN
resolver
uniprot_entry
MSI2H_HUMAN
resolver
uniprot_sec
Q7Z6M7
resolver
uniprot_sec
Q8N9T4
resolver
amino_acid_sequence
MEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIAGPLIATAFTNGYH
uniprot
proteins
disease_involvement
DISEASE: Note=Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23). {ECO:0000269|PubMed:12649177}.
uniprot
proteins
function
FUNCTION: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
35197
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Ubiquitinated by the RHOBTB2-CUL3-RBX1 ubiquitin ligase complex (PubMed:27941885). {ECO:0000250, ECO:0000269|PubMed:27941885}.
uniprot
proteins
protein_family
Musashi family
uniprot
proteins
pubmed
12649177
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
27941885
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with polysomes. {ECO:0000250}.
uniprot
proteins