NR2F6
entrez
2063
canonical
uniprot
P10588
canonical
ensembl
ENSG00000160113
resolver
ensp
ENSP00000291442
resolver
enst
ENST00000291442
resolver
genesymbol
NR2F6
resolver
genesymbol_syn
EAR2
resolver
genesymbol_syn
ERBAL2
resolver
hgnc
HGNC:7977
resolver
uniprot
B2RC68
resolver
uniprot
F1D8R3
resolver
uniprot
Q5XGA0
resolver
uniprot
Q6P586
resolver
uniprot
Q9BUE8
resolver
uniprot_entry
F1D8R3_HUMAN
resolver
uniprot_entry
NR2F6_HUMAN
resolver
uniprot_sec
B2RC68
resolver
uniprot_sec
Q5XGA0
resolver
uniprot_sec
Q6P586
resolver
uniprot_sec
Q9BUE8
resolver
amino_acid_sequence
MAMVTGGWGGPGGDTNGVDKAGGYPRAAEDDSASPPGAASDAEPGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQPVSELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYGSGQ
uniprot
proteins
function
FUNCTION: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:10713182, ECO:0000269|PubMed:11682620, ECO:0000269|PubMed:18701084}.
uniprot
proteins
mass_dalton
42979
uniprot
proteins
mutagenesis
MUTAGEN 74..78; /note="EGCKS->GSCKV: Loss of DNA (TRE) binding. Reduces the corepressor activity towards THRB."; /evidence="ECO:0000269|PubMed:10713182
uniprot
proteins
protein_family
NR2 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10644740
uniprot
proteins
pubmed
10713182
uniprot
proteins
pubmed
11682620
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18701084
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2905047
uniprot
proteins
sequence_length
404
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:18701084}.
uniprot
proteins