Ddx24
entrez
27225
canonical
uniprot
Q9ESV0
canonical
ensembl
ENSMUSG00000041645
resolver
ensp
ENSMUSP00000040890
resolver
ensp
ENSMUSP00000105628
resolver
ensp
ENSMUSP00000325747
resolver
ensp
ENSMUSP00000325749
resolver
enst
ENSMUST00000044923
resolver
enst
ENSMUST00000110001
resolver
genesymbol
Ddx24
resolver
uniprot
F8WJA0
resolver
uniprot
Q61119
resolver
uniprot
Q7TM97
resolver
uniprot_entry
DDX24_MOUSE
resolver
uniprot_entry
F8WJA0_MOUSE
resolver
uniprot_sec
Q61119
resolver
uniprot_sec
Q7TM97
resolver
amino_acid_sequence
MKVKETNSKPKLASRGTFQRKGIKIVGKWKQVTIDPNLFADGQMDDLVCFEELTDYRLVKNPSRLFSSEETKKRKAQAVSEEEEEEEGQSSSPKKKIKLKKQRDAARAAEGAAAQNEYEVKASEPEAQGEVTACSDQKVGGAKSESLAQAAPRKKKNKGKKKLDTFQSTSPKLPKKSKKTWMAEVHDQKADVSAWRDLFVPKAVLRALSFLGFSAPTPIQALTLAPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQWHKMKAPPIPRSTGMPPREMRFGATAHLGSPCKDRTESGVLPEEARIETEAQPSDSGVQATPETSASASAQTLLVCDDDAGEGPSSLEEKPVPKQNEDGEEKFDAEQAGKLKQELCDQIAIYKVHPRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHPHLSNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLNDSQYNPSRQTLVFSATLTLVHQAPARILHKKHVKKMDKTDKLDLLMQKVGMRGKPKVIDLTRNEGTVETLTETKIHCETDEKDLYLYYFLMQYPGRSLVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTARAASEGLSLMLIGPEDVINFKKIYKTLQKDEDIPLFPVQSKYMDVVKERIRLARQIEKAEYRNFQACLHNSWIEQAAAALEIELEEEMYKGGKADQQEERRRQKQMKMLKQELRHLLSQPLFQENLKTRYPTQSGRPPQPVLASRNIESALSCLSRQKRRRKKPKEPRAPPQPGSSTS
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity (PubMed:37470182). Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation. Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation (By similarity). Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA (By similarity). {ECO:0000250|UniProtKB:Q9GZR7}.
uniprot
proteins
mass_dalton
96429
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MDM2 without targeting DDX24 for proteasomal degradation. Instead, polyubiquitylated DDX24 promotes interaction with NIP7, a component of pre-rRNP processing complex, and associates with pre-rRNA molecules and pre-ribosomal particles. {ECO:0000250|UniProtKB:Q9GZR7}.
uniprot
proteins
protein_family
DDX24/MAK5 subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
10936056
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
37470182
uniprot
proteins
sequence_length
857
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9GZR7}. Nucleus {ECO:0000250|UniProtKB:Q9GZR7}.
uniprot
proteins