Arid5b
entrez
71371
canonical
uniprot
Q8BM75
canonical
ensembl
ENSMUSG00000019947
resolver
ensp
ENSMUSP00000151227
resolver
ensp
ENSMUSP00000151665
resolver
genesymbol
Arid5b
resolver
genesymbol_syn
Desrt
resolver
genesymbol_syn
Mrf2
resolver
uniprot
E9Q523
resolver
uniprot
Q8C0E0
resolver
uniprot
Q8K4G8
resolver
uniprot
Q8K4L9
resolver
uniprot
Q9CU78
resolver
uniprot
Q9JIX4
resolver
uniprot_entry
ARI5B_MOUSE
resolver
uniprot_sec
E9Q523
resolver
uniprot_sec
Q8C0E0
resolver
uniprot_sec
Q8K4G8
resolver
uniprot_sec
Q8K4L9
resolver
uniprot_sec
Q9CU78
resolver
uniprot_sec
Q9JIX4
resolver
amino_acid_sequence
MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFVRCTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQGRNSDHGEDEVIAVSEKVIVKLEDLVKWAHSDFSKWRCGLRATPVKTEAFGRNGQKEALLRYRQSTLNSGLNFKDVLKEKADLGEDEEETNVIVLSYPQYCRYRSMLKRIQDKPSSILTDQFALALGGIAVVSRNPQILYCRDTFDHPTLIENESVCDEFAPNLKGRPRKKKTCPQRRDSFSGSKDPNNNCDGKVISKVKGEARSALTKPKNNHNNCKKTSNEEKPKLSIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPIKPRKQENNTQENENKTKVSGNKRIKQEMAKNKKEKENTPKPQDTSEVSSEQRKEEETLNHKSAPEPLPAPEVKGKPEGHKDLGARAPVSRADPEKANETDQGSNSEKEAEEMGDKGLAPLLPSPPLPPEKDSAPTPGAGKQPLASPSTQMDSKQEAKPCCFTESPEKDLQGAPFSSFSATKPPLTSQNEAEEEQLPATANYIANCTVKVDQLGSDDIHTALKQTPKVLVVQSFDMFKDKDLTGPMNENHGLNYTPLLYSRGNPGIMSPLAKKKLLSQVSGASLSSSYPYGSPPPLISKKKLIAREDLCSGLSQGHHSQSSDHTAVSRPSVIQHVQSFKNKASEDRKSINDIFKHDKLSRSDAHRCGFSKHQLGSLADSYILKQETQEGKDKLLEKRAVSHAHVPSFLADFYSSPHLHSLYRHTEHHLHNEQSSKYAARDAYQESENGAFLSHKHPEKIHVNYLASLHLQDKKVAAAEASTDDQPTDLSLPKNPHKLTSKVLGLAHSTSGSQEIKGASQFQVVSNQSRDCHPKACRVSPMTMSGPKKYPESLARSGKPHQVRLENFRKMEGMVHPILHRKMSPQNIGAARPIKRSLEDLDLVIAGKKARAVSPLDPAKEASGKEKASEQESEGNKGAYGGHSGAASEGHKLPLSTPIFPGLYSGSLCNSGLNSRLPAGYSHSLQYLKNQTVLSPLMQPLAFHSLVMQRGIFTSPTNSQQLYRHLAAATPVGSSYGDLLHNSIYPLAGINPQAAFPSSQLSSVHPSTKL
uniprot
proteins
function
FUNCTION: Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-337, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver (By similarity). Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. {ECO:0000250, ECO:0000269|PubMed:12215486, ECO:0000269|PubMed:14651970, ECO:0000269|PubMed:17962384, ECO:0000269|PubMed:18070594, ECO:0000269|PubMed:19913508}.
uniprot
proteins
mass_dalton
131837
uniprot
proteins
post_translational_modification
PTM: Methylation at Lys-337 prevents DNA-binding. Demethylation by PHF2 promotes recruitment of the PHF2-ARID5B complex to promoters (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
ARID5B family
uniprot
proteins
pubmed
11404092
uniprot
proteins
pubmed
11483573
uniprot
proteins
pubmed
12215486
uniprot
proteins
pubmed
14651970
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17962384
uniprot
proteins
pubmed
18070594
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19913508
uniprot
proteins
sequence_length
1188
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:12215486}.
uniprot
proteins