Chrm3
entrez
12671
canonical
uniprot
Q9ERZ3
canonical
ensembl
ENSMUSG00000046159
resolver
ensp
ENSMUSP00000055579
resolver
ensp
ENSMUSP00000140131
resolver
enst
ENSMUST00000063093
resolver
enst
ENSMUST00000187510
resolver
genesymbol
Chrm3
resolver
genesymbol_syn
Chrm-3
resolver
uniprot
Q542R4
resolver
uniprot
Q64055
resolver
uniprot_entry
ACM3_MOUSE
resolver
uniprot_entry
Q542R4_MOUSE
resolver
uniprot_sec
Q64055
resolver
amino_acid_sequence
MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVSQLDSYNISQTSGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGTKRSSRRKYGGCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPDKDLGTMDVERNAHKLQAQKSMDDRDNCQKDFSKLPIQLESAVDTAKTSDTNSSVDKTTAALPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
uniprot
proteins
function
FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
uniprot
proteins
mass_dalton
66212
uniprot
proteins
protein_family
CHRM3 sub-subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Muscarinic acetylcholine receptor subfamily
uniprot
proteins
pubmed
19575010
uniprot
proteins
pubmed
21056967
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7874308
uniprot
proteins
sequence_length
589
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20309}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P20309}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P20309}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with TMEM147 in the endoplasmic reticulum (ER) membrane. TMEM147 impairs its trafficking to the cell membrane leading to its retention in the ER membrane. {ECO:0000250|UniProtKB:P20309}.
uniprot
proteins
transmembrane_region
TRANSMEM 67..90; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 104..129; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 142..163; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 184..205; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 229..251; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 491..513; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 526..545; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins