Kcnj16
entrez
16517
canonical
uniprot
Q9Z307
canonical
ensembl
ENSMUSG00000051497
resolver
ensp
ENSMUSP00000102246
resolver
ensp
ENSMUSP00000102247
resolver
ensp
ENSMUSP00000136382
resolver
ensp
ENSMUSP00000137414
resolver
ensp
ENSMUSP00000215379
resolver
enst
ENSMUST00000106635
resolver
enst
ENSMUST00000106636
resolver
enst
ENSMUST00000178798
resolver
enst
ENSMUST00000180023
resolver
genesymbol
Kcnj16
resolver
uniprot
Q8BH37
resolver
uniprot_entry
KCJ16_MOUSE
resolver
uniprot_sec
Q8BH37
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is strongly regulated by variations of cytosolic pH; channels are activated by alkaline and inhibited by acidic pH values. Activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2). {ECO:0000250|UniProtKB:P52191}.
uniprot
proteins
amino_acid_sequence
MSYYGSSYRIVNVDSKYPGYPPEHAIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYMVDIFTTLVDTKWRHMFVIFSLSYILSWLIFGSIFWLIAFHHGDLLSDPDITPCVDNVHSFTAAFLFSLETQTTIGYGYRCVTEECSVAVLTVILQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYSEDSEGRMTMAFKDLKLVNDQIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYIPREILWGHRFHDVLEVKRKYYKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLNNLEKTSPARGSCNSDTNTRRRSFSAVAVVSSCENPEETVLSPQDECKEMPYQKALLTLNRISMESQM
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules. {ECO:0000250|UniProtKB:Q9NPI9}.
uniprot
proteins
mass_dalton
48023
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ16 subfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33811157
uniprot
proteins
pubmed
9806850
uniprot
proteins
pubmed
9882736
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9NPI9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NPI9}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9NPI9}. Note=In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10. {ECO:0000250|UniProtKB:Q9NPI9}.
uniprot
proteins
transmembrane_region
TRANSMEM 68..94; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:F1NHE9"; TRANSMEM 144..171; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:F1NHE9
uniprot
proteins