Ano9
entrez
71345
canonical
uniprot
P86044
canonical
ensembl
ENSMUSG00000054662
resolver
ensp
ENSMUSP00000067689
resolver
enst
ENSMUST00000067836
resolver
genesymbol
Ano9
resolver
genesymbol_syn
Tmem16j
resolver
uniprot_entry
ANO9_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Cation channel activity is activated via phosphorylation on Ser-245 by cAMP-dependent protein kinase A (PKA) (PubMed:29604966, PubMed:36330924). Inhibited by NaCl (PubMed:29604966). {ECO:0000269|PubMed:29604966, ECO:0000269|PubMed:36330924}.
uniprot
proteins
amino_acid_sequence
MQDDESSQIFMGPEGDQLPLVEMGSCKPEASDQWDCVLVADLQTLKIQKHAQKQLQFLENLESNGFHFKMLKDQKKVFFGIRADSDVIDKYRTLLMNPEDSGSRDEQSFNIATTRIRIVSFVVNNKLKPGDTFEDLVKDGVFETMFLLHKGEQNLKNIWARWRNMFEPQPIDEIREYFGEKVALYFTWLGWYTYMLVPAAVVGLIVFLSGFALFDSSQISKEICSANDIFMCPLGDHSHRYLRLSEMCTFAKLTHLFDNEGTVLFAIFMALWATVFLEIWKRKRAHEVQSWKLYEWDEEEEEMALELINSPHYKLKDHRHSYLSSTIILILSLFMICLMIGMAHVLVVYRVLAGALFSSLVKQQVTTAVVVTGAVVHYIIIVIMTKVNKYVALKLCKFEESGTFSEQERKFTVKFFILQFFAHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHLSGCMMDLFIQMAIIMGLKQTLSNCVEYLCPLLAHKWRLMWASKHGHMSKDPELKEWQRNYYMNPINTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVRLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYHYGPCRTNRTFTDDCLTNYVNHSLSVFYTKHFNDHSRMEGQENVTVCRYRDYRNEHDYNLSEQFWFILAIRLTFVILFEHFALCIKLIAAWFVPDVPQKVKNEVLQEKYDRIRHRMRFSSRSTDV
uniprot
proteins
function
FUNCTION: PKA-activated nonselective cation channel (PubMed:29604966, PubMed:36330924). Discriminates poorly among cations but is more permeable to Ca(2+) ions than to monovalent cations (PubMed:29604966). Acts as a calcium-activated calcium permeable channel which may operate as a endoplasmic reticulum (ER) Ca(2+)-leak channel, reducing the loading of the ER Ca(2+) store (By similarity). Regulates intracellular Ca2+ signals, ion channel activity, and cytokine release in the renal tissue (By similarity). Plays an important role in olfaction, amplifying cAMP-evoked cyclic nucleotide-gated (CNG) channel currents in the olfactory sensory neurons (PubMed:36330924). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (PubMed:23532839). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity). Can inhibit the activity of ANO1 (By similarity). {ECO:0000250|UniProtKB:A1A5B4, ECO:0000269|PubMed:23532839, ECO:0000269|PubMed:29604966, ECO:0000269|PubMed:36330924}.
uniprot
proteins
mass_dalton
87180
uniprot
proteins
mutagenesis
MUTAGEN 245; /note="S->A: Loss of activation of its channel activity by cAMP-dependent protein kinase A (PKA)."; /evidence="ECO:0000269|PubMed:36330924
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-245 by cAMP-dependent protein kinase A (PKA)is essential for activation of its cation channel activity. {ECO:0000269|PubMed:29604966, ECO:0000269|PubMed:36330924}.
uniprot
proteins
protein_family
Anoctamin family
uniprot
proteins
pubmed
18729231
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20056604
uniprot
proteins
pubmed
22302790
uniprot
proteins
pubmed
23532839
uniprot
proteins
pubmed
29604966
uniprot
proteins
pubmed
36330924
uniprot
proteins
pubmed
36520003
uniprot
proteins
sequence_length
747
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29604966, ECO:0000269|PubMed:36330924}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:36330924}. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane. {ECO:0000250|UniProtKB:A1A5B4}.
uniprot
proteins
transmembrane_region
TRANSMEM 194..214; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 327..347; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 365..385; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 415..435; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 544..564; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 596..616; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 696..716; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins