Scaf4
entrez
224432
canonical
uniprot
Q7TSH6
canonical
ensembl
ENSMUSG00000022983
resolver
ensp
ENSMUSP00000044472
resolver
ensp
ENSMUSP00000132250
resolver
ensp
ENSMUSP00000156174
resolver
ensp
ENSMUSP00000201332
resolver
ensp
ENSMUSP00000201333
resolver
ensp
ENSMUSP00000201334
resolver
ensp
ENSMUSP00000201335
resolver
ensp
ENSMUSP00000201336
resolver
ensp
ENSMUSP00000201340
resolver
ensp
ENSMUSP00000346287
resolver
genesymbol
Scaf4
resolver
genesymbol_syn
AA517739
resolver
genesymbol_syn
Kiaa1172
resolver
genesymbol_syn
Sfrs15
resolver
genesymbol_syn
Srsf15
resolver
uniprot
A0A338P6Z6
resolver
uniprot
Q69ZP8
resolver
uniprot
Q6PFF0
resolver
uniprot
Q8BXA9
resolver
uniprot
Q8R1B3
resolver
uniprot_entry
Q8BXA9_MOUSE
resolver
uniprot_entry
SCAF4_MOUSE
resolver
uniprot_sec
A0A338P6Z6
resolver
uniprot_sec
Q69ZP8
resolver
uniprot_sec
Q6PFF0
resolver
uniprot_sec
Q8R1B3
resolver
amino_acid_sequence
MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKVPGLYVIDSIVRQSRHQFGTDKDVFGPRFSKNITATFQYLYLCPSEDKSKIVRVLNLWQKNGVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKISSELAQAPTNSMPTVAQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPQPQSPALDSAVMAQVQAITAQLKTAPTQPPEQKTAFDKKLLDRFDYDDEPEAVEDSKKEDAAAISTAALATAAPPAPTAATPAVATAVPVPSATSPPPPQTPFGYPGDGVQQPAYTQHQSMDQFQPRMMPIQQDTMHHQVPLPPNGQMPGFGLLSAPPPFPPMPQPGMPQPGMAQPGLAQPGMAQPTMPQPGMPQPGMPQPGMAQPGLAQPGMAQPGMPQPAMPQPAMPQPGMAQPGVSPAPPVQPTFQSTFQPQNEPHSQKPHQQEMEVEQPCVTEVKRHVPESRKSRSRSPKRRRSRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQERRDREKERERRQKGLPQIKSETASVCSTTLWVGQLDKRTTQQDVASLLEEFGPIESINMIPPRGCAYIVMVHRQDAYRALQKLSRGNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVTYIPWDKVKAEELESFCEGGMLDSDTLNPDWKGIPKKPDNEVAQNGGAETSHTEPVSPIPKPVPVPVPPIPVPAPITVPPPQVPPHQPGPPVVGALQPPAFTPPLGMPPPGFGPGVPPPPPPPPFLRPGFNPMHLPPGFLPPGPPPPITPPVSIPPPHTPPISIPNLVSGARGNAESGDSAKMYGSAGPPAAPTSLPTPPVTQPVSLLGTQGVAPGPVIGLQAPSTGLLGARPGLIPLQRPPGMPPPHLQRFPMMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGASEDRDGRQQQPQQQPPPQQQQQQQQPQQQPPQQSPSQQPAPAQQQPPQFRNDSRQQFNSGRDQERFGRRSFGSRVENDRERYGSRNDDRDNSNRERREWGRRSPDRDRHRDLEERSRRSSGHRDRDRDSRDRESRREKEENRKEKHEVADRAGGNKAVEPPLSQVGTIDTVSELNKGEAMATVVKPEESPAEVTSPVGPEKDPGSAAEPPR
uniprot
proteins
function
FUNCTION: Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough. {ECO:0000250|UniProtKB:O95104}.
uniprot
proteins
mass_dalton
129056
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95104}.
uniprot
proteins