PDLIM5
entrez
10611
canonical
uniprot
Q96HC4
canonical
ensembl
ENSG00000163110
resolver
ensp
ENSP00000321746
resolver
ensp
ENSP00000322021
resolver
ensp
ENSP00000352210
resolver
ensp
ENSP00000369527
resolver
ensp
ENSP00000398469
resolver
ensp
ENSP00000424297
resolver
ensp
ENSP00000442187
resolver
ensp
ENSP00000480359
resolver
enst
ENST00000437932
resolver
genesymbol
PDLIM5
resolver
genesymbol_syn
ENH
resolver
hgnc
HGNC:17468
resolver
uniprot
A0A0A0MSP3
resolver
uniprot
A8K6F9
resolver
uniprot
B7Z481
resolver
uniprot
B7Z8X5
resolver
uniprot
D6RB78
resolver
uniprot
E9PBF5
resolver
uniprot
O60705
resolver
uniprot
Q56VN4
resolver
uniprot
Q5UW38
resolver
uniprot
Q8WVK0
resolver
uniprot_entry
A0A0A0MSP3_HUMAN
resolver
uniprot_entry
B7Z481_HUMAN
resolver
uniprot_entry
B7Z8X5_HUMAN
resolver
uniprot_entry
PDLI5_HUMAN
resolver
uniprot_sec
A8K6F9
resolver
uniprot_sec
D6RB78
resolver
uniprot_sec
E9PBF5
resolver
uniprot_sec
O60705
resolver
uniprot_sec
Q56VN4
resolver
uniprot_sec
Q5UW38
resolver
uniprot_sec
Q8WVK0
resolver
amino_acid_sequence
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF
uniprot
proteins
function
FUNCTION: May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}.
uniprot
proteins
mass_dalton
63945
uniprot
proteins
pubmed
10429367
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15334068
uniprot
proteins
pubmed
15346770
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16044170
uniprot
proteins
pubmed
16213469
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20120020
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
596
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic density {ECO:0000250|UniProtKB:Q62920}. Presynapse {ECO:0000250|UniProtKB:Q62920}. Postsynapse {ECO:0000250|UniProtKB:Q62920}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q62920}. Note=Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons. {ECO:0000250|UniProtKB:Q62920}.
uniprot
proteins