Aqp11
entrez
286758
canonical
uniprot
Q8CHM1
canonical
ensembl
ENSRNOG00000013358
resolver
ensembl
ENSRNOG00055029934
resolver
ensembl
ENSRNOG00060002461
resolver
ensembl
ENSRNOG00065021617
resolver
ensp
ENSRNOP00000018091
resolver
ensp
ENSRNOP00055042794
resolver
ensp
ENSRNOP00060002788
resolver
ensp
ENSRNOP00065029597
resolver
enst
ENSRNOT00000018091
resolver
enst
ENSRNOT00055051857
resolver
enst
ENSRNOT00060003947
resolver
enst
ENSRNOT00065036759
resolver
genesymbol
Aqp11
resolver
uniprot
Q6AZ79
resolver
uniprot_entry
AQP11_RAT
resolver
uniprot_sec
Q6AZ79
resolver
amino_acid_sequence
MSALLGLPPEVQDTCISLGLMLLVVLFMGLARVIARQQLHRPMVHAFVLEFLATFQLCYCTHELQLLSEQDSGHPTWTLTLIYFFSLVHGLTLVGTASNPCGVMMQMILGGMSPEMGAVRLMAQLVSALCSRYCISALWSLSLTKYHFDERILACRNPINTDISKAIIIEAICSFIFHSALLHFQEVRTKLRIHVLAALITFLAYAGGSLTGALFNPALALSLHFPCFDESFYKFFVVYWVAPSLGVLLMILMFSFFLPWLHNNQLSNKKE
uniprot
proteins
function
FUNCTION: Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (By similarity). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER. Plays a role in the proximal tubule function by regulating its endosomal acidification. May play a role in postnatal kidney development (By similarity). {ECO:0000250|UniProtKB:Q8BHH1, ECO:0000250|UniProtKB:Q8NBQ7}.
uniprot
proteins
mass_dalton
30369
uniprot
proteins
post_translational_modification
PTM: Not glycosylated. {ECO:0000250|UniProtKB:Q8NBQ7}.
uniprot
proteins
protein_family
AQP11/AQP12 subfamily
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19812234
uniprot
proteins
pubmed
27107718
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8NBQ7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NBQ7}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8NBQ7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NBQ7}. Cell membrane {ECO:0000250|UniProtKB:F6S3G9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NBQ7}. Note=Localizes mainly to the periphery of lipid droplets. Localizes to cytoplasmic vesicles in maturing spermatozoa. It accumulates partly in mitochondrial-associated endoplasmic reticulum membranes. {ECO:0000250|UniProtKB:Q8NBQ7}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..35; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 42..62; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 77..97; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 195..215; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 235..255; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins