Itga8
entrez
241226
canonical
uniprot
A2ARA8
canonical
ensembl
ENSMUSG00000026768
resolver
ensp
ENSMUSP00000028106
resolver
ensp
ENSMUSP00000294875
resolver
ensp
ENSMUSP00000355259
resolver
genesymbol
Itga8
resolver
uniprot
O70304
resolver
uniprot
Q3UXV8
resolver
uniprot
Q8BRG3
resolver
uniprot
Q8C0H7
resolver
uniprot_entry
ITA8_MOUSE
resolver
uniprot_sec
O70304
resolver
uniprot_sec
Q3UXV8
resolver
uniprot_sec
Q8BRG3
resolver
uniprot_sec
Q8C0H7
resolver
amino_acid_sequence
MSAGTHCGPPGNRAPPFARLCCVSAALGMLWSPACLAFNLDVDKLTVYSGPEGSYFGYSLDFYIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPSERSAQCKQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVRAHKGKVVACAPLYHWRTLKPNPAKDPVGTCYVAIQNFSAYAEHSPCRNSNADPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITVSIADIIANYSFKDILRKLAAEKQTDVAPASYDDSYLGYSVAAGEFTGDSQQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNNDGMDDILVGAPLFMEREFESNPREVGQVYLYLQASALLFQDPQVLTGTETFGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNPRGLHSKPSQVLQGIWGSQTIPSGFGFSLRGDADIDKNDYPDLLVGAFGKGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQIPEFPTPVACFSVRVCASIAGQSISNTIALLAEVQLDFLKQKGAIKRTLFLHNHQSHFTFPFVMKQQKSLHCQDFMVYLRDETEFRDKLSPINISLNYSLDDSTFKDSLEVKPILNHYRDNVVTEQAHILVDCGEDNLCVPDLKLSARPDKHQIIIGDENHLMLIINARNEGEGAYEAELFVIIPEEADYVGIERNNKGLRPLSCEYKMENVTRMVVCDLGNPMVTGTNFSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFERVQINITAIAQVEIRGVSHPPQIVLPIHNWEPEKKPHKEEEVGPLVEHIYELHNIGPSTISDSILDVGWPFSARDEFLLYIFHLQTLGPLQCQTNPEINPQDIKPAASPEDTPELSAFLRNATIPHLVRKRDVPVVQLHRQSPARILNCTNIDCLQISCAVGRLGGGESAVLKVRSRLWAHTFLKRKNDHYALASLVSFEVKKMPYKEQPAKLPAGSTAVKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQDEMTDREQLTSDKTPEA
uniprot
proteins
function
FUNCTION: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. {ECO:0000269|PubMed:10742111, ECO:0000269|PubMed:11470831, ECO:0000269|PubMed:11891185, ECO:0000269|PubMed:12787402, ECO:0000269|PubMed:17537792, ECO:0000269|PubMed:9054500, ECO:0000269|PubMed:9548928, ECO:0000269|PubMed:9614184}.
uniprot
proteins
mass_dalton
117556
uniprot
proteins
protein_family
Integrin alpha chain family
uniprot
proteins
pubmed
10024342
uniprot
proteins
pubmed
10504498
uniprot
proteins
pubmed
10742111
uniprot
proteins
pubmed
11470831
uniprot
proteins
pubmed
11891185
uniprot
proteins
pubmed
12787402
uniprot
proteins
pubmed
14500699
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17537792
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9054500
uniprot
proteins
pubmed
9548928
uniprot
proteins
pubmed
9614184
uniprot
proteins
sequence_length
1062
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10742111}; Single-pass type I membrane protein {ECO:0000269|PubMed:10742111}. Cell membrane {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 1011..1031; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins