Mien1
entrez
103742
canonical
uniprot
Q9CQ86
canonical
ensembl
ENSMUSG00000002580
resolver
ensp
ENSMUSP00000002655
resolver
enst
ENSMUST00000002655
resolver
genesymbol
Mien1
resolver
genesymbol_syn
Rdx12
resolver
uniprot
A2A556
resolver
uniprot_entry
MIEN1_MOUSE
resolver
uniprot_sec
A2A556
resolver
amino_acid_sequence
MSGEPAPVSVVPPPGEVEAGSGVHIVVEYCKPCGFEATYLELASAVKEEYPGIEIESRLGGTGAFEIEINGQLVFSKLENGGFPYEKDLMEAIRRASNGEPVEKITNSRPPCVIL
uniprot
proteins
function
FUNCTION: Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
12295
uniprot
proteins
mutagenesis
MUTAGEN 30; /note="C->S: No effect on interaction with GPX1."; /evidence="ECO:0000269|PubMed:17503775"; MUTAGEN 33; /note="C->S: No effect on interaction with GPX1."; /evidence="ECO:0000269|PubMed:17503775
uniprot
proteins
post_translational_modification
PTM: Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation. {ECO:0000250}.
uniprot
proteins
protein_family
SelWTH family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17503775
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
115
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17503775}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions (By similarity). {ECO:0000250}.
uniprot
proteins