Elovl4
entrez
83603
canonical
uniprot
Q9EQC4
canonical
ensembl
ENSMUSG00000032262
resolver
ensp
ENSMUSP00000034796
resolver
enst
ENSMUST00000034796
resolver
genesymbol
Elovl4
resolver
uniprot
Q8JZV3
resolver
uniprot_entry
ELOV4_MOUSE
resolver
uniprot_sec
Q8JZV3
resolver
amino_acid_sequence
MGLLDSEPGSVLNAMSTAFNDTVEFYRWTWTIADKRVADWPLMQSPWPTISISTLYLLFVWLGPKWMKDREPFQMRLVLIIYNFGMVLLNLFIFRELFMGSYNAGYSYICQSVDYSNDVNEVRIAGALWWYFVSKGVEYLDTVFFILRKKNNQVSFLHVYHHCTMFTLWWIGIKWVAGGQAFFGAQMNSFIHVIMYSYYGLTAFGPWIQKYLWWKRYLTMLQLVQFHVTIGHTALSLYTDCPFPKWMHWALIAYAISFIFLFLNFYTRTYNEPKQSKTGKTATNGISSNGVNKSEKALENGKPQKNGKPKGE
uniprot
proteins
ec_number
2.3.1.199
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. {ECO:0000255|HAMAP-Rule:MF_03204, ECO:0000269|PubMed:18728184, ECO:0000269|PubMed:22158834, ECO:0000269|PubMed:22199362, ECO:0000269|PubMed:23479632, ECO:0000269|PubMed:23509295, ECO:0000269|PubMed:24569140}.
uniprot
proteins
mass_dalton
36506
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="T->A: Loss of N-glycosylation. No effect on fatty acid elongase activity."; /evidence="ECO:0000269|PubMed:24569140"; MUTAGEN 158; /note="H->Q: Loss of fatty acid elongase activity."; /evidence="ECO:0000269|PubMed:24569140"; MUTAGEN 161; /note="H->Q: Loss of fatty acid elongase activity."; /evidence="ECO:0000269|PubMed:24569140"; MUTAGEN 162; /note="H->Q: Loss of fatty acid elongase activity."; /evidence="ECO:0000269|PubMed:24569140"; MUTAGEN 308..310; /note="KPK->RKR: Loss of localization to the endoplasmic reticulum. Loss of fatty acid elongase activity."; /evidence="ECO:0000269|PubMed:24569140
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03204, ECO:0000269|PubMed:18728184, ECO:0000269|PubMed:22158834, ECO:0000269|PubMed:22199362, ECO:0000269|PubMed:23479632, ECO:0000269|PubMed:23509295, ECO:0000269|PubMed:24569140}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:23509295, ECO:0000269|PubMed:24569140}.
uniprot
proteins
protein_family
ELO family
uniprot
proteins
protein_family
ELOVL4 subfamily
uniprot
proteins
pubmed
11138005
uniprot
proteins
pubmed
15028285
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18728184
uniprot
proteins
pubmed
22158834
uniprot
proteins
pubmed
22199362
uniprot
proteins
pubmed
23479632
uniprot
proteins
pubmed
23509295
uniprot
proteins
pubmed
24569140
uniprot
proteins
sequence_length
312
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03204, ECO:0000269|PubMed:23509295, ECO:0000269|PubMed:24569140}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03204}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..62; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03204"; TRANSMEM 78..98; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03204"; TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03204"; TRANSMEM 165..185; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03204"; TRANSMEM 188..208; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03204"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03204"; TRANSMEM 246..266; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03204
uniprot
proteins