CXCR2
entrez
3579
canonical
uniprot
P25025
canonical
ensembl
ENSG00000180871
resolver
ensp
ENSP00000319635
resolver
ensp
ENSP00000545297
resolver
ensp
ENSP00000545298
resolver
ensp
ENSP00000545299
resolver
ensp
ENSP00000545300
resolver
ensp
ENSP00000609706
resolver
ensp
ENSP00000618593
resolver
enst
ENST00000318507
resolver
enst
ENST00000875238
resolver
enst
ENST00000875239
resolver
enst
ENST00000875240
resolver
enst
ENST00000875241
resolver
enst
ENST00000939647
resolver
enst
ENST00000948534
resolver
genesymbol
CXCR2
resolver
genesymbol
IL8RB
resolver
genesymbol_syn
IL8RB
resolver
hgnc
HGNC:6027
resolver
uniprot
Q53PC4
resolver
uniprot
Q8IUZ1
resolver
uniprot
Q9P2T6
resolver
uniprot
Q9P2T7
resolver
uniprot_entry
CXCR2_HUMAN
resolver
uniprot_entry
Q53PC4_HUMAN
resolver
uniprot_sec
Q8IUZ1
resolver
uniprot_sec
Q9P2T6
resolver
uniprot_sec
Q9P2T7
resolver
amino_acid_sequence
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
uniprot
proteins
disease_involvement
DISEASE: WHIM syndrome 2 (WHIMS2) [MIM:619407]: An autosomal recessive form of WHIM syndrome, a primary immunodeficiency disorder characterized by warts, hypogammaglobulinemia, infections, and myelokathexis. Myelokathexis is a unique form of non-cyclic severe congenital neutropenia caused by accumulation of mature and degenerating neutrophils in the bone marrow. Monocytopenia and lymphopenia, especially B lymphopenia, also commonly occur. There is significant phenotypic variation among patients, such that some individuals may have an incomplete form of the disorder in which one or more of the classic tetrad features are not present. {ECO:0000269|PubMed:24777453}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed:1891716). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698). Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (PubMed:1891716). Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. Signals intravascular neutrophil chemotaxis to the injury site. {ECO:0000250|UniProtKB:P35343, ECO:0000269|PubMed:1891716, ECO:0000269|PubMed:8662698}.
uniprot
proteins
mass_dalton
40759
uniprot
proteins
post_translational_modification
PTM: Phosphorylated upon ligand binding; which is required for desensitization. {ECO:0000269|PubMed:9079638}.; PTM: (Microbial infection) Proteolytically cleaved by Staphylococcus aureus staphopain A/SspP. This cleavage inhibits CXCR2-dependent neutrophil activation and chemotaxis. {ECO:0000269|PubMed:22850671}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11196695
uniprot
proteins
pubmed
1379593
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1891716
uniprot
proteins
pubmed
22850671
uniprot
proteins
pubmed
24777453
uniprot
proteins
pubmed
7512557
uniprot
proteins
pubmed
7929358
uniprot
proteins
pubmed
8384312
uniprot
proteins
pubmed
8662698
uniprot
proteins
pubmed
9079638
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 49..75; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 85..105; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 121..142; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 164..183; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 209..231; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 252..273; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 295..315; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins