PLLP
entrez
51090
canonical
uniprot
Q9Y342
canonical
ensembl
ENSG00000102934
resolver
ensp
ENSP00000219207
resolver
enst
ENST00000219207
resolver
genesymbol
PLLP
resolver
genesymbol_syn
PMLP
resolver
genesymbol_syn
TM4SF11
resolver
hgnc
HGNC:18553
resolver
uniprot
B2R9T6
resolver
uniprot_entry
PLLP_HUMAN
resolver
uniprot_sec
B2R9T6
resolver
amino_acid_sequence
MAEFPSKVSTRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTPYHLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAFIACSAAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQMAGGYA
uniprot
proteins
function
FUNCTION: Main component of the myelin sheath that plays an important role in myelin membrane biogenesis and myelination (PubMed:26002055). Plays an essential function in apical endocytosis. Regulates epithelial development through the regulation of apical endocytosis (By similarity). Part of the intracellular machinery that mediates basolateral-to-apical transport of ICAM-1, an essential adhesion receptor in epithelial cells, from the subapical compartment in hepatic epithelial cells (PubMed:34999972). {ECO:0000250|UniProtKB:A3KQ86, ECO:0000269|PubMed:26002055, ECO:0000269|PubMed:34999972}.
uniprot
proteins
mass_dalton
19987
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:P47987}.
uniprot
proteins
protein_family
MAL family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26002055
uniprot
proteins
pubmed
34999972
uniprot
proteins
sequence_length
182
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26002055}; Multi-pass membrane protein {ECO:0000255}. Myelin membrane {ECO:0000269|PubMed:26002055}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:P47987}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000269|PubMed:26002055}. Note=In polarized cells, localized predominantly in the apical membrane (By similarity). Located in lipid raft (By similarity). Recycled between the plasma membrane and the Golgi complex (PubMed:26002055). PLLP is continuously recirculating in the cell (PubMed:26002055). {ECO:0000250|UniProtKB:A3KQ86, ECO:0000250|UniProtKB:P47987, ECO:0000269|PubMed:26002055}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins