Erlin1
entrez
226144
canonical
uniprot
Q91X78
canonical
ensembl
ENSMUSG00000025198
resolver
ensp
ENSMUSP00000071618
resolver
ensp
ENSMUSP00000107659
resolver
ensp
ENSMUSP00000129684
resolver
ensp
ENSMUSP00000176758
resolver
enst
ENSMUST00000071698
resolver
enst
ENSMUST00000112028
resolver
enst
ENSMUST00000170801
resolver
genesymbol
Erlin1
resolver
genesymbol_syn
Keo4
resolver
genesymbol_syn
Spfh1
resolver
uniprot
A0A0R4J1G5
resolver
uniprot
Q3UKI9
resolver
uniprot
Q8CIH7
resolver
uniprot_entry
ERLN1_MOUSE
resolver
uniprot_sec
A0A0R4J1G5
resolver
uniprot_sec
Q3UKI9
resolver
uniprot_sec
Q8CIH7
resolver
amino_acid_sequence
MNMTQARLLVAAVVGLVAILLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNTMAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKRAVIEAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPSMFVDSSCALKYSDGRTGREDSLPPEEAREPSGESPIQNKENAG
uniprot
proteins
function
FUNCTION: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (By similarity). {ECO:0000250|UniProtKB:O75477}.
uniprot
proteins
mass_dalton
39182
uniprot
proteins
post_translational_modification
PTM: Deubiquitinated by USP25; leading to stabilization. {ECO:0000250|UniProtKB:O75477}.
uniprot
proteins
protein_family
Band 7/mec-2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21610068
uniprot
proteins
sequence_length
348
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins