SRRT
entrez
51593
canonical
uniprot
Q9BXP5
canonical
ensembl
ENSG00000087087
resolver
ensp
ENSP00000478341
resolver
ensp
ENSP00000480421
resolver
ensp
ENSP00000481173
resolver
ensp
ENSP00000483556
resolver
genesymbol
SRRT
resolver
genesymbol_syn
ARS2
resolver
genesymbol_syn
ASR2
resolver
hgnc
HGNC:24101
resolver
uniprot
A4D2E5
resolver
uniprot
A4D2E6
resolver
uniprot
A6NK22
resolver
uniprot
B4DJL4
resolver
uniprot
B4DZA6
resolver
uniprot
O95808
resolver
uniprot
Q32MI4
resolver
uniprot
Q6NT74
resolver
uniprot
Q8TDQ5
resolver
uniprot
Q9BWP6
resolver
uniprot
Q9BXP4
resolver
uniprot
Q9Y4S4
resolver
uniprot_entry
SRRT_HUMAN
resolver
uniprot_sec
A4D2E5
resolver
uniprot_sec
A4D2E6
resolver
uniprot_sec
A6NK22
resolver
uniprot_sec
B4DJL4
resolver
uniprot_sec
B4DZA6
resolver
uniprot_sec
O95808
resolver
uniprot_sec
Q32MI4
resolver
uniprot_sec
Q6NT74
resolver
uniprot_sec
Q8TDQ5
resolver
uniprot_sec
Q9BWP6
resolver
uniprot_sec
Q9BXP4
resolver
uniprot_sec
Q9Y4S4
resolver
amino_acid_sequence
MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASEPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPGLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF
uniprot
proteins
function
FUNCTION: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}.
uniprot
proteins
mass_dalton
100666
uniprot
proteins
protein_family
ARS2 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11239002
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17693683
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18086880
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19546234
uniprot
proteins
pubmed
19632182
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20858735
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25662211
uniprot
proteins
pubmed
26382858
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
30842217
uniprot
proteins
sequence_length
876
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity). {ECO:0000250}.
uniprot
proteins