Adamtsl4
entrez
229595
canonical
uniprot
Q80T21
canonical
ensembl
ENSMUSG00000015850
resolver
ensp
ENSMUSP00000015994
resolver
ensp
ENSMUSP00000113424
resolver
ensp
ENSMUSP00000319933
resolver
enst
ENSMUST00000015994
resolver
enst
ENSMUST00000117782
resolver
genesymbol
Adamtsl4
resolver
genesymbol_syn
Tsrc1
resolver
uniprot
Q148X6
resolver
uniprot_entry
ATL4_MOUSE
resolver
uniprot_sec
Q148X6
resolver
amino_acid_sequence
MESWLGRLWLCMMLLLPLPQPCQDQELFGPSHQLPSEEGQVPEGLWGPWGRWASCSQPCGVGVQRRSRTCELHPALPLPPRPPRHPEAHRPRGQGSRPQTPRDPQSLYRPQPRGRGGPLRAPASQVGREETQEPQGAQRFRVRDPIKPGMFGYGRVPFALPLHRSRRHPHRPGQPKNSSTGEGMVPSQPPSTELASEKHGPHMQPPEPRSHSAETPRSGTAQTEVLPRTSSAPSYTGTPAPTSSFGDSRSFQGSLGPRMPPSPGSWSSPQGAERRHPPPFSPVPRSQQSRRHWRPPGPHRSPDGWLPLTRDSSPLWSIFAPSIPAPNCSGESEQMRACSQEPCPPEQPDPRALQCAAFDSQEFMGQLYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGSLDICVAGRCLSPGCDGVLGSGRRPDGCGVCGGDGSTCRLVSGNLTDRGGPLGYQKILWIPAGASHLHISQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYTAIGTVFQYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEDNPGVFYQYVISSPPAVLESPSTKPPALQPQPEMLRGEPLLPSAPRPVRAPGTLQRQVRIPQVPPPTRVRTAMGSSAGYWKQVGHSECSASCGKGVWHPIFLCISRESGEELDEQSCAVGARPPASPEPCHGPPCPPYWEAGEWTSCSRSCGPGTQHRQLLCRQEFGGGGSSVPPERCGHLPRPNITQPCQLHLCGHWEISSPWSQCSVRCGRGQRSRQVRCVGSNGDEVDKQECASGPPPPPSREACDMGPCTTAWFYSDWSSKCSAECGTGIQRRAVVCLRSGETLQGDPEAGSTEQGCPLRSRPPDMRACSLGPCERTWRWFTGPWSECSSECGSGTQHRDIICVSKLGAEFNVTSPSNCSHLPRPPALQPCQGQACEDKWFSTLWSPCSRSCQGGMQTREVQCLSGNQTLSSRCPPHLRPSRKRPCNSQPCNQRPDDQCKDSSPHCPLVVQARLCVYPYYTTTCCRSCAHVLEQSQLEPA
uniprot
proteins
function
FUNCTION: Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
113225
uniprot
proteins
post_translational_modification
PTM: Glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
12706885
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
1036
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Colocalizes with FMN1 microfibrils in the eye ECM. {ECO:0000250}.
uniprot
proteins