MGLL
entrez
11343
canonical
uniprot
Q99685
canonical
ensembl
ENSG00000074416
resolver
ensp
ENSP00000265052
resolver
ensp
ENSP00000381176
resolver
ensp
ENSP00000404146
resolver
ensp
ENSP00000497905
resolver
ensp
ENSP00000534910
resolver
ensp
ENSP00000534911
resolver
enst
ENST00000265052
resolver
enst
ENST00000864852
resolver
genesymbol
MGLL
resolver
hgnc
HGNC:17038
resolver
uniprot
A0A0C4DFN3
resolver
uniprot
B2ZGL7
resolver
uniprot
B3KRC2
resolver
uniprot
B7Z9D1
resolver
uniprot
Q6IBG9
resolver
uniprot
Q96AA5
resolver
uniprot_entry
A0A0C4DFN3_HUMAN
resolver
uniprot_entry
B2ZGL7_HUMAN
resolver
uniprot_entry
MGLL_HUMAN
resolver
uniprot_sec
B3KRC2
resolver
uniprot_sec
B7Z9D1
resolver
uniprot_sec
Q6IBG9
resolver
uniprot_sec
Q96AA5
resolver
amino_acid_sequence
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
uniprot
proteins
ec_number
3.1.1.23
uniprot
proteins
function
FUNCTION: Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333). {ECO:0000269|PubMed:19029917, ECO:0000269|PubMed:20079333, ECO:0000269|PubMed:21049984, ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24368842}.
uniprot
proteins
mass_dalton
33261
uniprot
proteins
mutagenesis
MUTAGEN 194; /note="Y->F: Does not affect ability to hydrolyze 1- or 2-monoacylglycerol."; /evidence="ECO:0000269|PubMed:24368842"; MUTAGEN 201; /note="C->A: Does not affect ability to hydrolyze 1- or 2-monoacylglycerol."; /evidence="ECO:0000269|PubMed:24368842"; MUTAGEN 208; /note="C->A: Does not affect ability to hydrolyze 1- or 2-monoacylglycerol."; /evidence="ECO:0000269|PubMed:24368842"; MUTAGEN 242; /note="C->A: Reduced 1-monoacylglycerol lipase activity."; /evidence="ECO:0000269|PubMed:24368842
uniprot
proteins
pathway_participation
PATHWAY: Glycerolipid metabolism; triacylglycerol degradation. {ECO:0000250|UniProtKB:O35678}.
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
Monoacylglycerol lipase family
uniprot
proteins
pubmed
11470505
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19029917
uniprot
proteins
pubmed
19957260
uniprot
proteins
pubmed
19962385
uniprot
proteins
pubmed
20079333
uniprot
proteins
pubmed
21049984
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22969151
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24368842
uniprot
proteins
pubmed
9495531
uniprot
proteins
sequence_length
303
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O35678}. Membrane {ECO:0000250|UniProtKB:O35678}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35678}.
uniprot
proteins