BUB3
entrez
9184
canonical
uniprot
O43684
canonical
ensembl
ENSG00000154473
resolver
ensp
ENSP00000357851
resolver
ensp
ENSP00000357858
resolver
genesymbol
BUB3
resolver
hgnc
HGNC:1151
resolver
uniprot
A0A140VJF3
resolver
uniprot
A6NJ42
resolver
uniprot
B2R6E7
resolver
uniprot
D3DRE9
resolver
uniprot
O43685
resolver
uniprot_entry
A0A140VJF3_HUMAN
resolver
uniprot_entry
BUB3_HUMAN
resolver
uniprot_sec
A6NJ42
resolver
uniprot_sec
B2R6E7
resolver
uniprot_sec
D3DRE9
resolver
uniprot_sec
O43685
resolver
amino_acid_sequence
MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYEMDDTEHPEDGIFIRQVTDAETKPKSPCT
uniprot
proteins
function
FUNCTION: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:18199686}.
uniprot
proteins
mass_dalton
37155
uniprot
proteins
post_translational_modification
PTM: Poly-ADP-ribosylated by PARP1. {ECO:0000250|UniProtKB:Q9WVA3}.; PTM: Ubiquitinated by UBR5, promoting disassembly of the mitotic checkpoint complex from the APC/C complex. {ECO:0000269|PubMed:35217622}.
uniprot
proteins
protein_family
WD repeat BUB3 family
uniprot
proteins
pubmed
10198256
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15525512
uniprot
proteins
pubmed
18199686
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24462186
uniprot
proteins
pubmed
24462187
uniprot
proteins
pubmed
35217622
uniprot
proteins
pubmed
9660858
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition. {ECO:0000250}.
uniprot
proteins