Inhibition of eukaryotic host translation factors by virus
uniprot_keyword
KW-1075
canonical
name
Inhibition of eukaryotic host translation factors by virus
uniprot
definition
Viral protein that inhibits or degrades host translation initiation factor(s). Viruses have evolved ways of interacting with the cellular translational machinery to shutoff host gene expression. This global inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response. Some viruses are known to cleave host translation initiation factors like EIF3 or EIF4G, while others achieve translation inhibition by promoting dephosphorylation of some host translation initiation factors or their binding partners.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
uniprot_keywords
uniprot
keywords