FGF10
entrez
2255
canonical
uniprot
O15520
canonical
ensembl
ENSG00000070193
resolver
ensp
ENSP00000264664
resolver
ensp
ENSP00000582858
resolver
enst
ENST00000264664
resolver
enst
ENST00000912799
resolver
genesymbol
FGF10
resolver
hgnc
HGNC:3666
resolver
uniprot
C7FDY0
resolver
uniprot
Q6FHR3
resolver
uniprot
Q6FHT6
resolver
uniprot
Q96P59
resolver
uniprot_entry
FGF10_HUMAN
resolver
uniprot_sec
C7FDY0
resolver
uniprot_sec
Q6FHR3
resolver
uniprot_sec
Q6FHT6
resolver
uniprot_sec
Q96P59
resolver
amino_acid_sequence
MWKWILTHCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVALNGKGAPRRGQKTRRKNTSAHFLPMVVHS
uniprot
proteins
disease_involvement
DISEASE: Aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]: A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta. {ECO:0000269|PubMed:15654336}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Lacrimo-auriculo-dento-digital syndrome 3 (LADD3) [MIM:620193]: A form of lacrimo-auriculo-dento-digital syndrome, an autosomal dominant disease characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed. {ECO:0000269|PubMed:16501574, ECO:0000269|PubMed:16630169}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. {ECO:0000269|PubMed:16597617}.
uniprot
proteins
mass_dalton
23436
uniprot
proteins
protein_family
Heparin-binding growth factors family
uniprot
proteins
pubmed
12591959
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15654336
uniprot
proteins
pubmed
15806171
uniprot
proteins
pubmed
16501574
uniprot
proteins
pubmed
16597617
uniprot
proteins
pubmed
16630169
uniprot
proteins
pubmed
20094046
uniprot
proteins
pubmed
9287324
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins