Actr2
entrez
289820
canonical
uniprot
Q5M7U6
canonical
ensembl
ENSRNOG00000004959
resolver
ensembl
ENSRNOG00055007683
resolver
ensembl
ENSRNOG00060014606
resolver
ensembl
ENSRNOG00065006058
resolver
ensp
ENSRNOP00000006607
resolver
ensp
ENSRNOP00055010290
resolver
ensp
ENSRNOP00060019959
resolver
ensp
ENSRNOP00065006594
resolver
enst
ENSRNOT00055012905
resolver
enst
ENSRNOT00060025056
resolver
enst
ENSRNOT00065009205
resolver
genesymbol
Actr2
resolver
genesymbol_syn
Arp2
resolver
uniprot_entry
ARP2_RAT
resolver
amino_acid_sequence
MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR
uniprot
proteins
function
FUNCTION: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). {ECO:0000250|UniProtKB:P61160}.
uniprot
proteins
mass_dalton
44734
uniprot
proteins
protein_family
ARP2 subfamily
uniprot
proteins
protein_family
Actin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
394
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P61160}. Cell projection {ECO:0000250|UniProtKB:P61160}. Nucleus {ECO:0000250|UniProtKB:P61160}.
uniprot
proteins