Rangrf
entrez
57785
canonical
uniprot
Q9JIB0
canonical
ensembl
ENSMUSG00000032892
resolver
ensp
ENSMUSP00000038485
resolver
ensp
ENSMUSP00000347280
resolver
enst
ENSMUST00000038644
resolver
genesymbol
Rangrf
resolver
genesymbol_syn
Mog1
resolver
genesymbol_syn
Rangnrf
resolver
uniprot
Q9CWZ0
resolver
uniprot_entry
MOG1_MOUSE
resolver
uniprot_sec
Q9CWZ0
resolver
amino_acid_sequence
MEPNRNCPLFGGAFSAILPTGAIDVSDLRPVPDNQEVFCHPVTDQSLIIELLELQAHVQGEAAARYHFEDVGRVQGARAVHVLSVQPLCLENLSLRGCCQDAWSLSGKQQVAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPCHSRSLGPENLSCPPWSLSNFEQLVTSLTLHDPNLFGPQ
uniprot
proteins
function
FUNCTION: May regulate the intracellular trafficking of RAN (PubMed:10811801, PubMed:11733047). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:10811801, PubMed:11733047). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (By similarity). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830). {ECO:0000250|UniProtKB:Q9HD47, ECO:0000269|PubMed:10811801, ECO:0000269|PubMed:11733047, ECO:0000269|PubMed:18184654, ECO:0000269|PubMed:23420830}.
uniprot
proteins
mass_dalton
20413
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="D->A: Deficient in binding to RAN-GTP and in GTP release activity."; /evidence="ECO:0000269|PubMed:11733047"; MUTAGEN 29; /note="R->A: Increases GTP release from RAN."; /evidence="ECO:0000269|PubMed:11733047"; MUTAGEN 33; /note="D->A: Deficient in binding to RAN-GTP and in GTP release activity."; /evidence="ECO:0000269|PubMed:11733047"; MUTAGEN 36; /note="E->A: Deficient in binding to RAN-GTP and in GTP release activity."; /evidence="ECO:0000269|PubMed:11733047"; MUTAGEN 44; /note="D->A: Increases GTP release from RAN."; /evidence="ECO:0000269|PubMed:11733047
uniprot
proteins
protein_family
MOG1 family
uniprot
proteins
pubmed
10811801
uniprot
proteins
pubmed
11733047
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15716349
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18184654
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23420830
uniprot
proteins
sequence_length
185
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10811801, ECO:0000269|PubMed:11733047}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9HD47}. Cytoplasm {ECO:0000269|PubMed:18184654}. Cell membrane {ECO:0000250|UniProtKB:Q9HD47}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9HD47}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9HD47}. Note=Shuttles between the nucleus and cytoplasm. {ECO:0000269|PubMed:11733047}.
uniprot
proteins