Scyl1
entrez
78891
canonical
uniprot
Q9EQC5
canonical
ensembl
ENSMUSG00000024941
resolver
ensp
ENSMUSP00000025890
resolver
ensp
ENSMUSP00000157476
resolver
ensp
ENSMUSP00000158420
resolver
ensp
ENSMUSP00000202423
resolver
enst
ENSMUST00000025890
resolver
enst
ENSMUST00000236978
resolver
genesymbol
Scyl1
resolver
uniprot
A0A498WGE3
resolver
uniprot
Q3TST7
resolver
uniprot
Q3UKU0
resolver
uniprot
Q8K222
resolver
uniprot
R4H4Y7
resolver
uniprot_entry
A0A498WGE3_MOUSE
resolver
uniprot_entry
R4H4Y7_MOUSE
resolver
uniprot_entry
SCYL1_MOUSE
resolver
uniprot_sec
Q3TST7
resolver
uniprot_sec
Q3UKU0
resolver
uniprot_sec
Q8K222
resolver
amino_acid_sequence
MWFFARDPVRDFPFELSPEPPEGGPPGPWILHRGRKKATGSAVSIFVYDVKPGAEEQTQVAKAAFKRLKTLRHPNILAYIDGLETEKCLHIVTEAVTPLGTYLKARAEAGGLKEQELSWGLHQIVKALSFLVNDCNLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPSKGIPELEQYDPPELADSSSRAVREKWSADMWRLGCLIWEVFNGSLPRAAALRNPGKIPKSLVTHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDSFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKSLRAEEYQEKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVTHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDDQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATKDPFAPSRVAGVLGFAATHNLYSMDDCAHKILPVLCGLTVDPEKSVRDQAFKTIRSFLSKLESVSEDPTQLAEVEKDVHAASSPGTGGAAASWAGWAVTGVSSLTSKLIRAHPTPVPSDTTVPQRPVPEGNPAPAPALAQAIPATSGHWETQEDKDTAEDSATADRWDDEDWGSLEQEAESVLAQQDDWSAKGQGSRAGQINHPDHKSLESHWSSWEVEGSWDQGWQEPSSVEPPPEGTRLASEYNWGGAEPSDKGDPFAALSVRPSAQPRPDPDSWGEDNWEGLEAESRQVKAELARKKREERRREMEAKRAEKKTTKGPMKLGARKLD
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Scyl1 are the cause of the muscle deficient phenotype (mdf). Mice exhibit progressive neuromuscular atrophy, hindlimb paralysis, gait ataxia, abnormal hindlimb posture and tremor. Pathology of mdf comprises cerebellar atrophy, Purkinje cell loss and optic nerve atrophy. {ECO:0000269|PubMed:17571074}.
uniprot
proteins
function
FUNCTION: Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. {ECO:0000250|UniProtKB:Q96KG9}.
uniprot
proteins
mass_dalton
89160
uniprot
proteins
mutagenesis
MUTAGEN 791..792; /note="KK->AA: Decreased interaction with COPB1."; /evidence="ECO:0000269|PubMed:18556652
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11118629
uniprot
proteins
pubmed
12783284
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17571074
uniprot
proteins
pubmed
18556652
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
806
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:11118629, ECO:0000269|PubMed:12783284}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Golgi apparatus, cis-Golgi network {ECO:0000250}. Note=Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner. {ECO:0000250}.
uniprot
proteins