PON3
entrez
5446
canonical
uniprot
Q15166
canonical
ensembl
ENSG00000105852
resolver
ensp
ENSP00000265627
resolver
enst
ENST00000265627
resolver
genesymbol
PON3
resolver
hgnc
HGNC:9206
resolver
uniprot
A4D1H8
resolver
uniprot
O75855
resolver
uniprot
O76060
resolver
uniprot
Q6IRU9
resolver
uniprot
Q8IX97
resolver
uniprot
Q9BZH9
resolver
uniprot_entry
PON3_HUMAN
resolver
uniprot_sec
A4D1H8
resolver
uniprot_sec
O75855
resolver
uniprot_sec
O76060
resolver
uniprot_sec
Q6IRU9
resolver
uniprot_sec
Q8IX97
resolver
uniprot_sec
Q9BZH9
resolver
amino_acid_sequence
MGKLVALVLLGVGLSLVGEMFLAFRERVNASREVEPVEPENCHLIEELESGSEDIDILPSGLAFISSGLKYPGMPNFAPDEPGKIFLMDLNEQNPRAQALEISGGFDKELFNPHGISIFIDKDNTVYLYVVNHPHMKSTVEIFKFEEQQRSLVYLKTIKHELLKSVNDIVVLGPEQFYATRDHYFTNSLLSFFEMILDLRWTYVLFYSPREVKVVAKGFCSANGITVSADQKYVYVADVAAKNIHIMEKHDNWDLTQLKVIQLGTLVDNLTVDPATGDILAGCHPNPMKLLNYNPEDPPGSEVLRIQNVLSEKPRVSTVYANNGSVLQGTSVASVYHGKILIGTVFHKTLYCEL
uniprot
proteins
ec_number
3.1.1.2
uniprot
proteins
ec_number
3.1.1.81
uniprot
proteins
ec_number
3.1.8.1
uniprot
proteins
function
FUNCTION: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. {ECO:0000269|PubMed:15772423}.
uniprot
proteins
mass_dalton
39607
uniprot
proteins
post_translational_modification
PTM: The signal sequence is not cleaved. {ECO:0000250}.
uniprot
proteins
protein_family
Paraoxonase family
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772423
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8661009
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}.
uniprot
proteins