Erlin2
entrez
290823
canonical
uniprot
B5DEH2
canonical
ensembl
ENSRNOG00000013763
resolver
ensembl
ENSRNOG00055008213
resolver
ensembl
ENSRNOG00060011861
resolver
ensembl
ENSRNOG00065002719
resolver
ensp
ENSRNOP00000018973
resolver
ensp
ENSRNOP00055011150
resolver
ensp
ENSRNOP00060015736
resolver
ensp
ENSRNOP00065002579
resolver
enst
ENSRNOT00000018973
resolver
enst
ENSRNOT00055013899
resolver
enst
ENSRNOT00060020063
resolver
enst
ENSRNOT00065003699
resolver
genesymbol
Erlin2
resolver
genesymbol_syn
Spfh2
resolver
uniprot_entry
ERLN2_RAT
resolver
amino_acid_sequence
MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPHAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTALKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGGLGKQSEGLSDKLGFGLEDEPLETATKDN
uniprot
proteins
function
FUNCTION: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity). {ECO:0000250|UniProtKB:O94905}.
uniprot
proteins
mass_dalton
37710
uniprot
proteins
post_translational_modification
PTM: Deubiquitinated by USP25; leading to stabilization. {ECO:0000250|UniProtKB:O75477}.
uniprot
proteins
protein_family
Band 7/mec-2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:O94905}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins