Rnf152
entrez
320311
canonical
uniprot
Q8BG47
canonical
ensembl
ENSMUSG00000047496
resolver
ensp
ENSMUSP00000050103
resolver
ensp
ENSMUSP00000128632
resolver
ensp
ENSMUSP00000219470
resolver
enst
ENSMUST00000058688
resolver
enst
ENSMUST00000172299
resolver
genesymbol
Rnf152
resolver
uniprot
Q0VF67
resolver
uniprot_entry
RN152_MOUSE
resolver
uniprot_sec
Q0VF67
resolver
amino_acid_sequence
METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGITKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERTLLPGDMGCRLLPGSQQKSLTVVTIPAEQQPLQGGAPPEAVEEEPDRRGVVKSSTWSGVCTVILVACVLVFLLGIVLHNMSCISKRFTVISCG
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB (PubMed:25936802). Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling (PubMed:25936802). Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition (By similarity). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation (By similarity). Induces apoptosis when overexpressed (By similarity). {ECO:0000250|UniProtKB:Q8N8N0, ECO:0000269|PubMed:25936802}.
uniprot
proteins
mass_dalton
22353
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8N8N0}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:Q8N8N0}.
uniprot
proteins
protein_family
RNF152 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
25936802
uniprot
proteins
pubmed
29300766
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q8N8N0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8N8N0}.
uniprot
proteins
transmembrane_region
TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins