Rnf14
entrez
56736
canonical
uniprot
Q9JI90
canonical
ensembl
ENSMUSG00000060450
resolver
ensp
ENSMUSP00000072212
resolver
ensp
ENSMUSP00000126205
resolver
ensp
ENSMUSP00000133070
resolver
ensp
ENSMUSP00000157833
resolver
ensp
ENSMUSP00000277998
resolver
ensp
ENSMUSP00000278005
resolver
ensp
ENSMUSP00000278011
resolver
ensp
ENSMUSP00000278012
resolver
ensp
ENSMUSP00000278021
resolver
ensp
ENSMUSP00000278031
resolver
ensp
ENSMUSP00000278040
resolver
ensp
ENSMUSP00000278048
resolver
ensp
ENSMUSP00000278053
resolver
ensp
ENSMUSP00000278061
resolver
ensp
ENSMUSP00000278067
resolver
ensp
ENSMUSP00000278082
resolver
enst
ENSMUST00000170811
resolver
genesymbol
Rnf14
resolver
genesymbol_syn
Triad2
resolver
uniprot
G3XA54
resolver
uniprot
Q7TPR0
resolver
uniprot
Q9D0L2
resolver
uniprot
Q9D6N2
resolver
uniprot
Q9D6Z8
resolver
uniprot
Q9JI89
resolver
uniprot_entry
G3XA54_MOUSE
resolver
uniprot_entry
RNF14_MOUSE
resolver
uniprot_sec
Q7TPR0
resolver
uniprot_sec
Q9D0L2
resolver
uniprot_sec
Q9D6N2
resolver
uniprot_sec
Q9D6Z8
resolver
uniprot_sec
Q9JI89
resolver
amino_acid_sequence
MSAEDLEAQEDELLALASIYDADEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNESLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGRVVLFAWMQFLKEETLTYLNIVSPFELKMGSQKKVQRRATAQASSSTELGVGGAAAADVDQEETVDERAVQDVESLSSLIQEILDFNQARQTKCFNSKLFLCSICFCEKLGSDCMYFLECKHVYCKACLKDYFEIQIKDGQVKCLNCPEPQCPSVATPGQVKELVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAICSSCNFAFCTLCRLTYHGLSPCKVTAEKLIDLRNEYLQADEATKRFLEQRYGKRVIQKALEEMESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWICMGSLSRANPYRHFTDSESPCFNRLFHAVDINGDMWEDEIEEDDDDEDDDDD
uniprot
proteins
ec_number
2.3.2.31
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity). Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates 'Lys-6'-linked ubiquitination of target proteins, leading to their degradation (By similarity). Mediates ubiquitination of EEF1A1/eEF1A and ETF1/eRF1 translation factors on stalled ribosomes, leading to their degradation (By similarity). Also catalyzes ubiquitination of ribosomal proteins RPL0, RPL1, RPL12, RPS13 and RPS17 (By similarity). Specifically required to resolve RNA-protein cross-links caused by reactive aldehydes, which trigger translation stress by stalling ribosomes: acts by catalying 'Lys-6'-linked ubiquitination of RNA-protein cross-links, leading to their removal by the ATP-dependent unfoldase VCP and subsequent degradation by the proteasome (By similarity). Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interaction with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4) (By similarity). May also play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (PubMed:24472305). {ECO:0000250|UniProtKB:Q9UBS8, ECO:0000269|PubMed:24472305}.
uniprot
proteins
mass_dalton
54926
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9UBS8}.
uniprot
proteins
post_translational_modification
PTM: RING-type zinc finger-dependent and UBE2E2-dependent autoubiquitination. {ECO:0000250|UniProtKB:Q9UBS8}.
uniprot
proteins
protein_family
RBR family
uniprot
proteins
protein_family
RNF14 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24472305
uniprot
proteins
sequence_length
485
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UBS8}. Nucleus {ECO:0000250|UniProtKB:Q9UBS8}.
uniprot
proteins