Lmnb1
entrez
116685
canonical
uniprot
P70615
canonical
ensembl
ENSRNOG00000013774
resolver
ensp
ENSRNOP00000019351
resolver
enst
ENSRNOT00000019351
resolver
genesymbol
Lmnb1
resolver
uniprot
G3V7U4
resolver
uniprot_entry
G3V7U4_RAT
resolver
uniprot_entry
LMNB1_RAT
resolver
amino_acid_sequence
MATATPVQQRAGSRASAPATPFSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELADARRALDDTARERAKLQIELGKFKAEHDQLLLNYAKKESDLSGAQIKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLSAAKKQLADETLLKVDLENRCQSLTEDLEFRKNMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSARGGMMESRMRIESLSSQLSNLQKDSRACLERIQELEDMLAKERDNSRRMLSDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGKRKRVDVEESEASSSVSISHSASATGNVCIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRKIGDTSVSYKYTSRYVLKAGQTVTVWAANAGVTASPPTDLIWKNQNSWGTGEDVKVVLKNSQGEEVAQRSTVFKTTIPEEEEEEEEEPIGVPLEEERFHQQGTPRASNKSCAIM
uniprot
proteins
function
FUNCTION: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively. Plays a role in sperm morphological development during late stages of spermiogenesis, particularly the anchoring of the sperm head to the tail (By similarity). Component of the LMNB1/SUN5/SEPT12 bridge that connects the sperm proximal centriole to the implantation fossa, the bridge functions to prevent detachment of the proximal centriole from the posterior nucleus during spermiogenesis (By similarity). {ECO:0000250|UniProtKB:P14733}.
uniprot
proteins
mass_dalton
66606
uniprot
proteins
post_translational_modification
PTM: B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. {ECO:0000250|UniProtKB:P20700}.; PTM: Phosphorylation plays a key role in lamin organization, subcellular localization and nuclear envelope disintegration. Phosphorylation by CDK1 at Ser-23 and Ser-393 at the onset of mitosis drives lamin disassembly and nuclear envelope breakdown. {ECO:0000250|UniProtKB:P02545}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
16128803
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
587
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus lamina {ECO:0000250|UniProtKB:P14733}. Note=Expressed in the posterior part of the nucleus during steps 9 to 12 of spermiogenesis, expression became more localized to the implantation fossa between steps 13 to 16 (By similarity). Expressed at the neck region in mature sperm (By similarity). {ECO:0000250|UniProtKB:P14733}.
uniprot
proteins