Fnta
entrez
14272
canonical
uniprot
Q61239
canonical
ensembl
ENSMUSG00000015994
resolver
ensp
ENSMUSP00000016138
resolver
enst
ENSMUST00000016138
resolver
genesymbol
Fnta
resolver
uniprot
Q541Z2
resolver
uniprot
Q921F7
resolver
uniprot_entry
FNTA_MOUSE
resolver
uniprot_entry
Q541Z2_MOUSE
resolver
uniprot_sec
Q921F7
resolver
activity_regulation
ACTIVITY REGULATION: Activated by the AGRIN-induced phosphorylation which is mediated by MUSK. {ECO:0000269|PubMed:14622576}.
uniprot
proteins
amino_acid_sequence
MAATEGVGESAAGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYITAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILSQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDVYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHCRESDIPASV
uniprot
proteins
ec_number
2.5.1.58
uniprot
proteins
ec_number
2.5.1.59
uniprot
proteins
function
FUNCTION: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO:0000269|PubMed:14622576, ECO:0000269|PubMed:17652517}.
uniprot
proteins
mass_dalton
44013
uniprot
proteins
mutagenesis
MUTAGEN 164; /note="K->A: Inhibits prenylation activity. In myoblasts, impaired insulin-induced RAC1 activation, possibly due to impaired insulin-induced geranyl-geranyltransferase activation. No effect on MUSK-binding."; /evidence="ECO:0000269|PubMed:14622576"; MUTAGEN 200; /note="Y->F: Inhibits prenylation activity. In myoblasts, impaired insulin-induced RAC1 activation, possibly due to impaired insulin-induced geranyl-geranyltransferase activation. 68% decrease in MUSK-binding."; /evidence="ECO:0000269|PubMed:14622576
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA. {ECO:0000269|PubMed:14622576}.
uniprot
proteins
protein_family
Protein prenyltransferase subunit alpha family
uniprot
proteins
pubmed
14622576
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17652517
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7590362
uniprot
proteins
sequence_length
377
uniprot
proteins