Rnf10
entrez
50849
canonical
uniprot
Q3UIW5
canonical
ensembl
ENSMUSG00000041740
resolver
ensp
ENSMUSP00000041778
resolver
ensp
ENSMUSP00000107725
resolver
ensp
ENSMUSP00000107726
resolver
ensp
ENSMUSP00000304336
resolver
enst
ENSMUST00000040555
resolver
enst
ENSMUST00000112097
resolver
genesymbol
Rnf10
resolver
genesymbol_syn
Kiaa0262
resolver
genesymbol_syn
Rie2
resolver
genesymbol_syn
Sid2705
resolver
uniprot
D3Z1N2
resolver
uniprot
H7BX06
resolver
uniprot
Q6PDS8
resolver
uniprot
Q6ZQE8
resolver
uniprot
Q91YZ9
resolver
uniprot
Q9R0P0
resolver
uniprot_entry
D3Z1N2_MOUSE
resolver
uniprot_entry
H7BX06_MOUSE
resolver
uniprot_entry
RNF10_MOUSE
resolver
uniprot_sec
Q6PDS8
resolver
uniprot_sec
Q6ZQE8
resolver
uniprot_sec
Q91YZ9
resolver
uniprot_sec
Q9R0P0
resolver
amino_acid_sequence
MPQSSPSAAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSNGSKRYNRKREPSYPKNENFSNQSRRSNSQKSKTFNKMPPQRGGGSSKPFSSSSNGGRRDEVAEAQRAEFSPAQFSGPKKINLNHLLNFTFEPRGQAGHFEGSGHGGWGKRNKWGHKPFNKELFLQANCQFVVSEDQDYAAHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYSSVHKKDLKSVVATESRQYAVGDTITMQLMKREKGVLVALPKSKWVNVDHPINLGDEQLSQYSKLLLASKEQVLHRVVLEEKGALEQQLAEEKHTPESCFIEAAIQEVKIREEALSGVAGGGGEVTGVVAALEHLVLMAPLATESAFQPRKGVLEYLSAFDDEAAQVCSLDPPGPLALPLVEEEEAVSEPEACEDAEVADDSLGEGTVGPEMSQEEPITKPGFTQLSSSPCYYFYQAEDGQHMFLHPVNVRCLVREYGSLEQSPEKISATVVEIAGYSMSEDVRQRHRYLSHLPLTCEFSICELALQPPVVSKETLEMFSDDIEKRKRQRQKKAREERRRERRIEMEENKRQGRYPEVHIPLENLQQFPAFNSYTCPSDSALGPTSTEGHGALSLSPLSRSPGSHADFLLTPLSPTASQGSPSFCVGSLEDDSPFLSFAQMLRVGKAKADGWPKTAPKKDDNSLVPPAPVDSDGESDNSDRVPVPSFQNSFSQAIEAAFMKLDTPATSDPLSEDRGGKKRKRQKQKLLFSTSVVHTK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling. Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC) or elongation. The ribosome quality control is activated in response to ribosome subunit imbalance, amino acid starvation or downstream the EIF2AK4/GCN2-mediated integrated stress response (ISR). RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3: monoubiquitinated RPS2/us5 and RPS3/us3 are then recognized by RIOK3 kinase, leading to 18S non-functional rRNA decay and degradation of the 40S ribosomal subunit. The action of RNF10 in iRQC is counteracted by USP10. {ECO:0000250|UniProtKB:Q8N5U6}.
uniprot
proteins
mass_dalton
88345
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8N5U6}.
uniprot
proteins
protein_family
RNF10 family
uniprot
proteins
pubmed
10697961
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
804
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8N5U6}. Nucleus {ECO:0000250|UniProtKB:Q5XI59}.
uniprot
proteins