Enpp6
entrez
320981
canonical
uniprot
Q8BGN3
canonical
ensembl
ENSMUSG00000038173
resolver
ensp
ENSMUSP00000044608
resolver
ensp
ENSMUSP00000259248
resolver
enst
ENSMUST00000039840
resolver
genesymbol
Enpp6
resolver
uniprot
Q4VAH5
resolver
uniprot_entry
ENPP6_MOUSE
resolver
uniprot_sec
Q4VAH5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by EDTA and EGTA in vitro. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MAAKLWTFLLGFGLSWVWPASAHRKLLVLLLDGFRSDYISEDALASLPGFREIVNRGVKVDYLTPDFPSLSYPNYYTLMTGRHCEVHQMIGNYMWDPRTNKSFDIGVNRDSLMPLWWNGSEPLWITLMKARRKVYMYYWPGCEVEILGVRPTYCLEYKTVPTDINFANAVSDALDSLKSGRADLAAIYHERIDVEGHHYGPSSPQRKDALRAVDTVLKYMIQWIQDRGLQQDLNVILFSDHGMTDIFWMDKVIELSNYISLDDLQQVKDRGPVVSLWPVPGKHSEIYHKLRTVEHMTVYEKESIPNRFYYKKGKFVSPLTLVADEGWFIAESREMLPFWMNSTGKREGWQRGWHGYDNELMDMRGIFLAIGPDFKSNFRAAPIRSVDVYNIMCHVAGITPLPNNGSWSRVVCMLKGQTSSAPPTPLNSCALVLILLLYFV
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
ec_number
3.1.4.38
uniprot
proteins
function
FUNCTION: Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells (PubMed:15788404, PubMed:26888014). Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids (PubMed:15788404). In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids (PubMed:15788404). {ECO:0000269|PubMed:15788404, ECO:0000269|PubMed:26888014}.
uniprot
proteins
mass_dalton
50618
uniprot
proteins
mutagenesis
MUTAGEN 71; /note="S->A: Almost loss of glycerophosphocholine cholinephosphodiesterase activity. Loss of choline metabolism."; /evidence="ECO:0000269|PubMed:26888014"; MUTAGEN 71; /note="S->T: Almost loss of glycerophosphocholine cholinephosphodiesterase activity. Loss of choline metabolism."; /evidence="ECO:0000269|PubMed:26888014"; MUTAGEN 72; /note="Y->A: Highly decreases glycerophosphocholine cholinephosphodiesterase activity. Loss of choline metabolism."; /evidence="ECO:0000269|PubMed:26888014"; MUTAGEN 75; /note="Y->A: Highly decreases glycerophosphocholine cholinephosphodiesterase activity. Loss of choline metabolism."; /evidence="ECO:0000269|PubMed:26888014"; MUTAGEN 154; /note="C->A: Highly decreases glycerophosphocholine cholinephosphodiesterase activity. Loss of choline metabolism."; /evidence="ECO:0000269|PubMed:26888014"; MUTAGEN 188; /note="Y->A: Highly decreases glycerophosphocholine cholinephosphodiesterase activity. Loss of choline metabolism."; /evidence="ECO:0000269|PubMed:26888014"; MUTAGEN 190; /note="E->A: Highly decreases glycerophosphocholine cholinephosphodiesterase activity. Loss of choline metabolism."; /evidence="ECO:0000269|PubMed:26888014"; MUTAGEN 393; /note="C->A: Does not affect glycerophosphocholine cholinephosphodiesterase activity; when associated with S-412. Does not affect choline metabolism; when associated with S-412."; /evidence="ECO:0000269|PubMed:26888014"; MUTAGEN 412; /note="C->S: Does not affect Glycerophosphocholine cholinephosphodiesterase activity; when associated with A-393. Does not affect choline metabolism; when associated with A-393."; /evidence="ECO:0000269|PubMed:26888014
uniprot
proteins
protein_family
Nucleotide pyrophosphatase/phosphodiesterase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15788404
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26888014
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
uniprot
proteins