Pla2g2e
entrez
26970
canonical
uniprot
Q9QUL3
canonical
ensembl
ENSMUSG00000028751
resolver
ensp
ENSMUSP00000030531
resolver
ensp
ENSMUSP00000101430
resolver
enst
ENSMUST00000030531
resolver
enst
ENSMUST00000105804
resolver
genesymbol
Pla2g2e
resolver
uniprot
Q3UG05
resolver
uniprot_entry
PA2GE_MOUSE
resolver
uniprot_entry
Q3UG05_MOUSE
resolver
amino_acid_sequence
MKPPIALACLCLLVPLAGGNLVQFGVMIERMTGKPALQYNDYGCYCGVGGSHWPVDETDWCCHAHDCCYGRLEKLGCDPKLEKYLFSITRDNIFCAGRTACQRHTCECDKRAALCFRHNLNTYNRKYAHYPNKLCTGPTPPC
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:10531313, PubMed:11922621). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), releasing various unsaturated fatty acids including oleoate, linoleoate, arachidonate, docosahexaenoate and lysophosphatidylethanolamines in preference to lysophosphatidylcholines (By similarity). In response to high-fat diet, hydrolyzes minor lipoprotein phospholipids including phosphatidylserines, phosphatidylinositols and phosphatidylglycerols, altering lipoprotein composition and fat storage in adipose tissue and liver (PubMed:24910243). May act in an autocrine and paracrine manner (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria (By similarity). Acts as a hair follicle phospholipase A2. Selectively releases lysophosphatidylethanolamines (LPE) and various unsaturated fatty acids in skin to regulate hair follicle homeostasis (PubMed:27226633). May regulate the inflammatory response by releasing arachidonate, a precursor of prostaglandins and leukotrienes. Upon allergen exposure, may participate in allergic inflammatory response by enhancing leukotriene C4 synthesis and degranulation in mast cells (PubMed:11922621). {ECO:0000250|UniProtKB:Q9NZK7, ECO:0000269|PubMed:10531313, ECO:0000269|PubMed:11922621, ECO:0000269|PubMed:24910243, ECO:0000269|PubMed:27226633}.
uniprot
proteins
mass_dalton
15943
uniprot
proteins
protein_family
Phospholipase A2 family
uniprot
proteins
pubmed
10531313
uniprot
proteins
pubmed
10681567
uniprot
proteins
pubmed
11922621
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24910243
uniprot
proteins
pubmed
27226633
uniprot
proteins
sequence_length
142
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11922621}. Cytoplasm {ECO:0000269|PubMed:11922621}. Note=Through binding to heparan sulfate proteoglycan, may be localized to cytoplasmic compartments enriched in anionic phospholipids. {ECO:0000250|UniProtKB:Q9NZK7}.
uniprot
proteins