SH3RF1
entrez
57630
canonical
uniprot
Q7Z6J0
canonical
ensembl
ENSG00000154447
resolver
ensp
ENSP00000284637
resolver
genesymbol
SH3RF1
resolver
genesymbol_syn
KIAA1494
resolver
genesymbol_syn
POSH
resolver
genesymbol_syn
POSH1
resolver
genesymbol_syn
RNF142
resolver
genesymbol_syn
SH3MD2
resolver
hgnc
HGNC:17650
resolver
uniprot
Q05BT2
resolver
uniprot
Q8IW46
resolver
uniprot
Q9HAM2
resolver
uniprot
Q9P234
resolver
uniprot_entry
SH3R1_HUMAN
resolver
uniprot_sec
Q05BT2
resolver
uniprot_sec
Q8IW46
resolver
uniprot_sec
Q9HAM2
resolver
uniprot_sec
Q9P234
resolver
amino_acid_sequence
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVEELPSNILLVRLLDGIKQRPWKPGPGGGSGTNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNGVAGSPSVVPAAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAAGLSPASVGLSHHSLASPQPAPLMPGSATHTAAISISRASAPLACAAAAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing its dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity). {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:19710010, ECO:0000269|PubMed:20696164}.; FUNCTION: (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on its RING domain, and hence its E3 ligase activity. {ECO:0000269|PubMed:15659549}.
uniprot
proteins
mass_dalton
93129
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="V->A: Loss of Ubl activity."; /evidence="ECO:0000269|PubMed:17420289"; MUTAGEN 28; /note="C->A: Significant reduction in autoubiquitination; when associated with A-30."; /evidence="ECO:0000269|PubMed:20696164"; MUTAGEN 30; /note="H->A: Significant reduction in autoubiquitination; when associated with A-28."; /evidence="ECO:0000269|PubMed:20696164"; MUTAGEN 304; /note="S->A: Decreased level of phosphorylation and no change in the ability to induce apoptosis."; /evidence="ECO:0000269|PubMed:17535800"; MUTAGEN 304; /note="S->D: Decreased level of phosphorylation and Rac-binding ability and important loss of the ability to induce apoptosis."; /evidence="ECO:0000269|PubMed:17535800"; MUTAGEN 304; /note="S->E: Decreased Rac-binding ability."; /evidence="ECO:0000269|PubMed:17535800
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-304 by AKT1 and AKT2. When phosphorylated, it has reduced ability to bind Rac. {ECO:0000269|PubMed:17535800}.; PTM: Autoubiquitinated (PubMed:20696164). Ubiquitinated by SH3RF2, leading to proteasome-mediated degradation (By similarity). {ECO:0000250|UniProtKB:Q71F54, ECO:0000269|PubMed:20696164}.
uniprot
proteins
protein_family
SH3RF family
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
12514131
uniprot
proteins
pubmed
14504284
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15659549
uniprot
proteins
pubmed
16230351
uniprot
proteins
pubmed
16571722
uniprot
proteins
pubmed
17420289
uniprot
proteins
pubmed
17535800
uniprot
proteins
pubmed
19710010
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20696164
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
888
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q71F54}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q69ZI1}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:17420289}. Note=Colocalizes, with AKT2, in lamellipodia (By similarity). Colocalizes, with HERP1, in trans-Golgi network. {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:17420289}.
uniprot
proteins