PPP1R14D
entrez
54866
canonical
uniprot
Q9NXH3
canonical
ensembl
ENSG00000166143
resolver
ensp
ENSP00000299174
resolver
ensp
ENSP00000398342
resolver
ensp
ENSP00000591671
resolver
ensp
ENSP00000591672
resolver
enst
ENST00000299174
resolver
enst
ENST00000427255
resolver
enst
ENST00000921612
resolver
enst
ENST00000921613
resolver
genesymbol
PPP1R14D
resolver
genesymbol_syn
GBPI
resolver
hgnc
HGNC:14953
resolver
uniprot
E9PAT1
resolver
uniprot
Q4V755
resolver
uniprot
Q4V773
resolver
uniprot_entry
E9PAT1_HUMAN
resolver
uniprot_entry
PP14D_HUMAN
resolver
uniprot_entry
Q4V755_HUMAN
resolver
uniprot_sec
Q4V773
resolver
amino_acid_sequence
MLSSSPASCTSPSPDGENPCKKVHWASGRRRTSSTDSESKSHPDSSKIPRSRRPSRLTVKYDRGQLQRWLEMEQWVDAQVQELFQDQATPSEPEIDLEALMDLSTEEQKTQLEAILGNCPRPTEAFISELLSQLKKLRRLSRPQK
uniprot
proteins
function
FUNCTION: Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. {ECO:0000269|PubMed:12974676}.
uniprot
proteins
mass_dalton
16508
uniprot
proteins
mutagenesis
MUTAGEN 21..22; /note="KK->EE: Reduces inhibitory activity by 57%."; /evidence="ECO:0000269|PubMed:12974676"; MUTAGEN 25; /note="W->A: Reduces inhibitory activity by 13%."; /evidence="ECO:0000269|PubMed:12974676"; MUTAGEN 58; /note="T->E: Reduces inhibitory activity by 16%. Reduces phosphorylation."; /evidence="ECO:0000269|PubMed:12974676
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on several residues. {ECO:0000269|PubMed:12974676}.
uniprot
proteins
protein_family
PP1 inhibitor family
uniprot
proteins
pubmed
12974676
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
145
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins