DTX2
entrez
113878
canonical
uniprot
Q86UW9
canonical
ensembl
ENSG00000091073
resolver
ensp
ENSP00000322885
resolver
ensp
ENSP00000390218
resolver
ensp
ENSP00000392545
resolver
ensp
ENSP00000411986
resolver
ensp
ENSP00000569061
resolver
ensp
ENSP00000569063
resolver
ensp
ENSP00000569065
resolver
ensp
ENSP00000569067
resolver
ensp
ENSP00000569069
resolver
ensp
ENSP00000569070
resolver
ensp
ENSP00000569076
resolver
ensp
ENSP00000590610
resolver
ensp
ENSP00000590611
resolver
ensp
ENSP00000590613
resolver
ensp
ENSP00000614794
resolver
ensp
ENSP00000652879
resolver
genesymbol
DTX2
resolver
genesymbol_syn
KIAA1528
resolver
genesymbol_syn
RNF58
resolver
hgnc
HGNC:15973
resolver
uniprot
Q4ZH49
resolver
uniprot
Q6XM87
resolver
uniprot
Q6XM88
resolver
uniprot
Q96H69
resolver
uniprot
Q9H890
resolver
uniprot
Q9P200
resolver
uniprot_entry
DTX2_HUMAN
resolver
uniprot_sec
Q4ZH49
resolver
uniprot_sec
Q6XM87
resolver
uniprot_sec
Q6XM88
resolver
uniprot_sec
Q96H69
resolver
uniprot_sec
Q9H890
resolver
uniprot_sec
Q9P200
resolver
amino_acid_sequence
MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRFGLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEWLSDDGSWTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRRQAGPPYPVTTIIAPPGHTGVACSCHQCLSGSRTGPVSGRYRHSMTNLPAYPVPQHPPHRTASVFGTHQAFAPYNKPSLSGARSAPRLNTTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIGLPVCLSRAPQPTSPPASRLASKSHGSVKRLRKMSVKGATPKPEPEPEQVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHLLCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYSIPHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that conjugates ubiquitin to ADP-ribosylated cysteine residues, independently of lysine side chains or free N-termini (PubMed:40681873). For example, PARP7 generates an ADP-ribosyl degron within the DNA-binding domain of the androgen receptor (AR), which is recognized by DTX2 and targeted for proteasomal degradation (PubMed:40681873). Functions in genome stability maintenance by acting as an ADP-ribosylation-dependent regulator of DNA double-strand break repair (PubMed:38992439). Mechanistically, recognizes PARylated substrates generated in response to DNA damage and promotes their ubiquitination via its RING and DTC domains (PubMed:38992439). Also regulates additional cellular pathways through ubiquitination of specific substrates. Acts as an E3 ubiquitin ligase for RNA demethylase FTO, promoting its ubiquitination and proteasomal degradation (PubMed:39661064). In turn, regulates antitumor immune responses (PubMed:39661064). Promotes 'Lys-27'-linked ubiquitination of TFRC, thereby modulating iron metabolism and inhibiting ferroptosis (PubMed:41772062). In addition, promotes transcription of telomerase reverse transcriptase by mediating 'Lys-63'-linked ubiquitination of nuclear factor 1 C-type (NFIC) that stabilizes its binding on hTERT promoter (PubMed:35198878). {ECO:0000269|PubMed:35198878, ECO:0000269|PubMed:38992439, ECO:0000269|PubMed:39661064, ECO:0000269|PubMed:40681873, ECO:0000269|PubMed:41772062}.
uniprot
proteins
mass_dalton
67246
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="W->A: Loss of binding to PARylated substrates; when associated with A-114."; /evidence="ECO:0000269|PubMed:32937373"; MUTAGEN 114; /note="W->A: Loss of binding to PARylated substrates; when associated with A-24."; /evidence="ECO:0000269|PubMed:32937373
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
Deltex family
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
11564735
uniprot
proteins
pubmed
12670957
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
32937373
uniprot
proteins
pubmed
35198878
uniprot
proteins
pubmed
38992439
uniprot
proteins
pubmed
39661064
uniprot
proteins
pubmed
40681873
uniprot
proteins
pubmed
41772062
uniprot
proteins
sequence_length
622
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:35198878, ECO:0000269|PubMed:38992439}. Cytoplasm {ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:35198878, ECO:0000269|PubMed:41772062}. Nucleus {ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:35198878}. Note=Predominantly cytoplasmic. Partially nuclear. Is recruited to DSBs in a PARylation-dependent manner (PubMed:38992439). {ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:38992439}.
uniprot
proteins