Senp3
entrez
80886
canonical
uniprot
Q9EP97
canonical
ensembl
ENSMUSG00000005204
resolver
ensp
ENSMUSP00000005336
resolver
ensp
ENSMUSP00000066581
resolver
enst
ENSMUST00000005336
resolver
enst
ENSMUST00000066760
resolver
genesymbol
Senp3
resolver
genesymbol_syn
Smt3ip
resolver
genesymbol_syn
Smt3ip1
resolver
uniprot
Q5F2A5
resolver
uniprot
Q8BRD5
resolver
uniprot
Q8C2H5
resolver
uniprot_entry
SENP3_MOUSE
resolver
uniprot_sec
Q5F2A5
resolver
uniprot_sec
Q8BRD5
resolver
uniprot_sec
Q8C2H5
resolver
activity_regulation
ACTIVITY REGULATION: On oxidative stress, SENP3 degradation is blocked by inhibition of its ubiquitination, which stabilizes it as it accumulates in the nucleoplasm. {ECO:0000250|UniProtKB:Q9H4L4}.
uniprot
proteins
amino_acid_sequence
MKETIQGTGSWGPEPPGPGTTYSNPRRERLRWPLPPKPRLKSGGGFGPDPGSGTTVPTRRLPAPRPSFDASASEEEEEEEEEDEEEVAAWRLPPRWGQLGASQRSRALRPSHRKTCSQRRRRAMRAFQMLLYSKSTSLTFHWKLWGRHRGRRRNLAHPKNHLSPQEGGATPQVPSPCCRFDSPRGLPPPRLGLLGALMAEDGMRGSPPVPSGPPMEEDGLRWTPKSPLDPDSGLLSCTLPNGFGGLSGPEGERSLAPPDASILISNVCSIGDHVAQELFQSSDLGIAEEADRTGEKAGQHSPLREEHVTCVQSILDEFLQTYGSLIPLSTDEVVEKLEDIFQQEFSTPSRKSLVLQLIQSYQRMPGNAMVRGFRVSYKRHVLTMDDLGTLYGQNWLNDQVMNMYGDLVMDTVPEKVHFFNSFFYDKLRTKGYDGVKRWTKNVDIFNKELLLIPIHLEVHWSLISVDVRRRTITYFDSQRTLNRRCPKHIAKYLQAEAVKKDRLDFHQGWKGYFKMNVARQNNDSDCGAFVLQYCKHLALSQPFSFTQQDMPKLRRQIYKELCHCKLTV
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
function
FUNCTION: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:11029585). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (By similarity). Deconjugates SUMO2 and SUMO3 from CDCA8 (By similarity). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (By similarity). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (By similarity). Plays a role in the regulation of sumoylation status of ZNF148 (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (By similarity). Catalyzes desumoylation of MRE11 (By similarity). {ECO:0000250|UniProtKB:Q9H4L4, ECO:0000269|PubMed:11029585, ECO:0000269|PubMed:22872859}.
uniprot
proteins
mass_dalton
64403
uniprot
proteins
protein_family
Peptidase C48 family
uniprot
proteins
pubmed
10806345
uniprot
proteins
pubmed
11029585
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22872859
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11029585}. Nucleus, nucleoplasm {ECO:0000269|PubMed:22872859}. Cytoplasm {ECO:0000269|PubMed:22872859}. Note=Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress (By similarity). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (PubMed:22872859). {ECO:0000250|UniProtKB:Q9H4L4, ECO:0000269|PubMed:22872859}.
uniprot
proteins