Cox6b2
entrez
333182
canonical
uniprot
Q80ZN9
canonical
ensembl
ENSMUSG00000051811
resolver
ensp
ENSMUSP00000064988
resolver
ensp
ENSMUSP00000138288
resolver
ensp
ENSMUSP00000138709
resolver
ensp
ENSMUSP00000138744
resolver
ensp
ENSMUSP00000138765
resolver
ensp
ENSMUSP00000139239
resolver
enst
ENSMUST00000063324
resolver
enst
ENSMUST00000182048
resolver
enst
ENSMUST00000182111
resolver
enst
ENSMUST00000182173
resolver
enst
ENSMUST00000182738
resolver
enst
ENSMUST00000184143
resolver
genesymbol
Cox6b2
resolver
uniprot
Q059Q8
resolver
uniprot
Q3KNG2
resolver
uniprot
S4R1N0
resolver
uniprot
S4R2Q6
resolver
uniprot
V9GXN3
resolver
uniprot_entry
CX6B2_MOUSE
resolver
uniprot_entry
Q059Q8_MOUSE
resolver
uniprot_entry
S4R1N0_MOUSE
resolver
uniprot_entry
S4R2Q6_MOUSE
resolver
uniprot_entry
V9GXN3_MOUSE
resolver
uniprot_sec
Q3KNG2
resolver
amino_acid_sequence
MLGVQAQKPPPGQWTTPPFDPRFPNQNQTRNCYQNFLDYHRCVKTMNRRGKSTQPCEYYFRVFHSLCPISWVQRWNEQIKQGTFPGKI
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:Q01519}.
uniprot
proteins
mass_dalton
10521
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:Q01519}.
uniprot
proteins
protein_family
Cytochrome c oxidase subunit 6B family
uniprot
proteins
pubmed
12874793
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
88
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00429}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00429}; Intermembrane side {ECO:0000250|UniProtKB:P00429}.
uniprot
proteins