Slc39a12
entrez
277468
canonical
uniprot
Q5FWH7
canonical
ensembl
ENSMUSG00000036949
resolver
ensp
ENSMUSP00000080911
resolver
ensp
ENSMUSP00000257249
resolver
ensp
ENSMUSP00000257250
resolver
ensp
ENSMUSP00000257251
resolver
ensp
ENSMUSP00000257253
resolver
ensp
ENSMUSP00000257260
resolver
ensp
ENSMUSP00000257270
resolver
genesymbol
Slc39a12
resolver
genesymbol_syn
Zip12
resolver
uniprot
A2AQ76
resolver
uniprot_entry
S39AC_MOUSE
resolver
uniprot_sec
A2AQ76
resolver
amino_acid_sequence
MCFWTNLSVWMILLSHSLSLVSSTETGKTLTQNNSRAGSQGLLEVLRVLSAGDHWSLNHPQSLIKILLERTGCPQRTDWTQGDCKLCLEADALLLTAGGNLEDELREEVVQRVSLLLLYYIIHQEEICSSKLNMSNREYEFYLHSLLGLRQDEDSYFLSEKETDDILAFTRKYFGTSSSQCMETKILQRESGIQGSNGADEKTLPQLAATIIALSLQGVCLGRKALPSPDDFTEYIFSFLNSTNTLHLSEIEQLLNMLTTRRTCAKEDKYLHQYQRKQNTEEHSLRDPKTSTAMDKESDDHSPSWDQACFSARQLVEIFLQNHSSLSISKEDFKQLSPGIIQQLLSCSCQMPKDQQAKPPPTTLEKYGYSTVAVTLLTLGSMLGTALVLFHSCEENYSLILQLFVGLAVGTLSGDALLHLIPQVLGLHKQEAEFGHFHESQSPIWKLLGLLGGIHGFFLIEKCFILLVSPNTKGLPLVNEHVGHTHHLGLNPELNDQSSGGKSISTIQLKGPEDSQTTVLPIGNVPASNRNGKTISLLAIMILVGDSLHNFADGLVIGTAFSSSLESGVTTTIAILCHEIPHEMGDFAVLLSSGLSVRTAILMNFLSALTAFAGLYIGLSVSADPRVQDWILTVTAGMFLYLSLVGMLPEMTHVQTQRPWMTFLLQNVGLVLGWFSLLLLAVYEQNIKI
uniprot
proteins
function
FUNCTION: Uniporter that promotes Zn(2+) import from the extracellular space to the cytoplasm across the cell membrane (PubMed:23716681, PubMed:35065654). The transport activity is temperature dependent (PubMed:23716681). May play a role in neurulation and neurite extension (PubMed:23716681). May play a key role in maintaining intracellular zinc content at levels that reduce the inhibitory effects of rises in oxidative stress on spermatogonia and spermatozoa viability during spermatogenesis (PubMed:35065654). {ECO:0000269|PubMed:23716681, ECO:0000269|PubMed:35065654}.
uniprot
proteins
mass_dalton
76215
uniprot
proteins
protein_family
ZIP transporter (TC 2.A.5) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23716681
uniprot
proteins
pubmed
35065654
uniprot
proteins
sequence_length
689
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:23716681}; Multi-pass membrane protein {ECO:0000255}. Note=At low Zn(2+) extracellular concentration, is redistributed from the perinuclear space to the cytoplasm and plasma membrane. {ECO:0000269|PubMed:23716681}.
uniprot
proteins
transmembrane_region
TRANSMEM 202..222; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 370..390; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 398..418; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 448..468; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 537..557; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 601..621; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 630..650; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 663..683; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins