Slc4a9
entrez
240215
canonical
uniprot
A0A494BA31
canonical
ensembl
ENSMUSG00000024485
resolver
ensp
ENSMUSP00000073910
resolver
ensp
ENSMUSP00000111358
resolver
ensp
ENSMUSP00000157460
resolver
ensp
ENSMUSP00000157862
resolver
ensp
ENSMUSP00000158033
resolver
ensp
ENSMUSP00000158071
resolver
ensp
ENSMUSP00000158410
resolver
enst
ENSMUST00000074298
resolver
enst
ENSMUST00000115694
resolver
enst
ENSMUST00000235181
resolver
enst
ENSMUST00000236124
resolver
enst
ENSMUST00000236126
resolver
enst
ENSMUST00000236779
resolver
enst
ENSMUST00000237174
resolver
genesymbol
Slc4a9
resolver
genesymbol_syn
AE4
resolver
uniprot
A0A494BAI0
resolver
uniprot
A0A494BBC3
resolver
uniprot
E9PUP3
resolver
uniprot
F6YY80
resolver
uniprot
Q14CH2
resolver
uniprot
Q14DJ1
resolver
uniprot
Q3UQE1
resolver
uniprot
Q8BUG8
resolver
uniprot_entry
A0A494BAI0_MOUSE
resolver
uniprot_entry
A0A494BBC3_MOUSE
resolver
uniprot_entry
B3A4_MOUSE
resolver
uniprot_entry
E9PUP3_MOUSE
resolver
uniprot_entry
F6YY80_MOUSE
resolver
uniprot_entry
Q14CH2_MOUSE
resolver
uniprot_entry
Q14DJ1_MOUSE
resolver
uniprot_entry
Q3UQE1_MOUSE
resolver
uniprot_entry
Q8BUG8_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Cl(-)/HCO3(-) exchanger activity is substantially increased in response to 5 uM isoproterenol (PubMed:34585968). Cl(-)/HCO3(-) exchanger activity is increased by both forskolin and coexpression with the catalytic subunit alpha of PKA (PubMed:34585968). {ECO:0000269|PubMed:34585968}.
uniprot
proteins
amino_acid_sequence
MKLPGQGDFESSDAHENAHSEEPDSGLGPGPGLNGPSGIDIGESQVSKDPLLFIQLNELLGWPQALEWRETGRWLLFEEKLDMGAGRWSAPHVPTLELPSLQKLRSLLAEGIVLLDCQAQSLLELVEQVVSGESLSPELRGQLQALLLQRPQHHIQTMGIRPCRESNAFRKASRDEDAPLKHQNPLRQKLPAGAEAAAVLAGELGFLEQPLGAFVRLRNPIVLEPLTEMILPSRFFCLLLGPPTLGRSYHEMGRAAAVLLSDPQFQWSVRRASHLPDLLAALDAFLQEVTALPPGRWDRTARIPPPKYLPSQHKRFPSKLQEVTSLSRQSAALAEDKHHHGPHTPIPELQRTGRLFGGLIQDVRRKACWYTSDFLDALHPQCFSAVFYIYLATVTNAITFGGLLGDATEGAQGVLESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVTAFCLALVATEASLLVRYFTRFTEEGFCALISLIFIYDAMGKMLNLIRAYPIQRPGSSAYGCFCQYPGTGGNTSEWTSAKLKDTEDILSVPGLVNASFLPPPECIRQGGHPLGPSCHTVPDIAFFSLLLFFTSFLCAIALKHIKNSRFFPSVVRKVLGDFSSVLAILLGCGLDTFLGLATPKLLVPTEFKPTLSGRGWLVSPFGANPWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSALGLPWYVSATVISLAHIDSLRRESKACIPGEAPNFLGIREQRLTGLVVFVLTGVSIFLAPVLKFIPMPVLYGIFLYMGVAALSSIQFVKRVQLLLMPRKHQPDMLLLRHVPLSRVHLFTAIQLACLGLLWVVKSTPAAIVFPLMLLGLVAIRKALEWVFSPQELLWLDELMPEEEETIPENRSEPEHLFSGNDSEDSELMYQPKAPEINISVN
uniprot
proteins
function
FUNCTION: Electroneutral Cl(-)/HCO3(-) antiporter that favors chloride ion entry and efflux of hydrogencarbonate and sodium ion across the basolateral membrane and may participate in salivary secretion (PubMed:25745107, PubMed:27114614). Also mediates Cl(-)/HCO3(-) exchange activity in the presence of K(+) as well as Cs(+), Li(+), and Rb(+) (PubMed:27114614). Does not contribute to Cl(-)/HCO3(-) exchanger in the apical membrane of the upper villous epithelium (PubMed:17170027). {ECO:0000269|PubMed:17170027, ECO:0000269|PubMed:25745107, ECO:0000269|PubMed:27114614}.
uniprot
proteins
mass_dalton
104989
uniprot
proteins
mutagenesis
MUTAGEN 173; /note="S->A: Significantly decreases Cl(-)/HCO3(-) antiporter activity. Does not affect plasma membrane localization. Abolishes PKA-mediated Cl(-)/HCO3(-) antiporter activity."; /evidence="ECO:0000269|PubMed:34585968"; MUTAGEN 273; /note="S->A: Significantly decreases Cl(-)/HCO3(-) antiporter activity. Does not affect plasma membrane localization. Does not affect PKA-mediated Cl(-)/HCO3(-) antiporter activity."; /evidence="ECO:0000269|PubMed:34585968
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
12225984
uniprot
proteins
pubmed
17170027
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23610411
uniprot
proteins
pubmed
25745107
uniprot
proteins
pubmed
27114614
uniprot
proteins
pubmed
34585968
uniprot
proteins
sequence_length
952
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12225984, ECO:0000269|PubMed:23610411, ECO:0000305|PubMed:34585968}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in the basolateral membrane of the cortical collecting duct (CCD)and submandibular gland (SMG) duct. {ECO:0000269|PubMed:12225984, ECO:0000269|PubMed:23610411}.
uniprot
proteins
transmembrane_region
TRANSMEM 385..405; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 413..433; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 501..521; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 593..613; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 634..654; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 681..701; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 727..747; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 784..804; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 807..827; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 870..890; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins