TNS4
entrez
84951
canonical
uniprot
Q8IZW8
canonical
ensembl
ENSG00000131746
resolver
ensp
ENSP00000254051
resolver
ensp
ENSP00000546665
resolver
enst
ENST00000254051
resolver
genesymbol
TNS4
resolver
genesymbol_syn
CTEN
resolver
hgnc
HGNC:24352
resolver
uniprot
A6NMJ7
resolver
uniprot
Q6PJP3
resolver
uniprot
Q71RB7
resolver
uniprot
Q8WV64
resolver
uniprot
Q96JV4
resolver
uniprot_entry
Q6PJP3_HUMAN
resolver
uniprot_entry
TENS4_HUMAN
resolver
uniprot_sec
A6NMJ7
resolver
uniprot_sec
Q71RB7
resolver
uniprot_sec
Q8WV64
resolver
uniprot_sec
Q96JV4
resolver
amino_acid_sequence
MSQVMSSPLLAGGHAVSLAPCDEPRRTLHPAPSPSLPPQCSYYTTEGWGAQALMAPVPCMGPPGRLQQAPQVEAKATCFLPSPGEKALGTPEDLDSYIDFSLESLNQMILELDPTFQLLPPGTGGSQAELAQSTMSMRKKEESEALDIKYIEVTSARSRCHDGPQHCSSPSVTPPFGSLRSGGLLLSRDVPRETRSSSESLIFSGNQGRGHQRPLPPSEGLSPRPPNSPSISIPCMGSKASSPHGLGSPLVASPRLEKRLGGLAPQRGSRISVLSASPVSDVSYMFGSSQSLLHSSNSSHQSSSRSLESPANSSSSLHSLGSVSLCTRPSDFQAPRNPTLTMGQPRTPHSPPLAKEHASSCPPSITNSMVDIPIVLINGCPEPGSSPPQRTPGHQNSVQPGAASPSNPCPATRSNSQTLSDAPFTTCPEGPARDMQPTMKFVMDTSKYWFKPNITREQAIELLRKEEPGAFVIRDSSSYRGSFGLALKVQEVPASAQSRPGEDSNDLIRHFLIESSAKGVHLKGADEEPYFGSLSAFVCQHSIMALALPCKLTIPQRELGGADGASDSTDSPASCQKKSAGCHTLYLSSVSVETLTGALAVQKAISTTFERDILPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLTTLRFCGMDPEQRKWQKYCKPSWIFGFVAKSQTEPQENVCHLFAEYDMVQPASQVIGLVTALLQDAERM
uniprot
proteins
function
FUNCTION: Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}.
uniprot
proteins
mass_dalton
76764
uniprot
proteins
mutagenesis
MUTAGEN 100..118; /note="Missing: Abolishes focal adhesion localization; when associated with A-474."; /evidence="ECO:0000269|PubMed:30321615"; MUTAGEN 474; /note="R->A: Abolishes interaction with DLC1. Abolishes interaction with CBL following EGF stimulation. Loss of ability to reduce ubiquitination of activated EGFR. Significant decrease in interaction with MET, faster MET trafficking to the lysosome and significant increase in MET turnover. Significant inhibition of basal and HGF-stimulated cell migration. No effect on focal adhesion localization. Abolishes focal adhesion localization; when associated with 100-F--L-118 DEL."; /evidence="ECO:0000269|PubMed:17190795, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316, ECO:0000269|PubMed:30321615"; MUTAGEN 506; /note="D->A: No effect on cleavage by caspase-3."; /evidence="ECO:0000269|PubMed:15806167"; MUTAGEN 570; /note="D->A: Abolishes cleavage by caspase-3."; /evidence="ECO:0000269|PubMed:15806167"; MUTAGEN 650; /note="R->A: Abolishes interaction with ITGB1. Does not affect interaction with CBL following EGF stimulation."; /evidence="ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by caspase-3 during apoptosis. {ECO:0000269|PubMed:15806167}.
uniprot
proteins
protein_family
PTEN phosphatase protein family
uniprot
proteins
pubmed
12154022
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
15806167
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17190795
uniprot
proteins
pubmed
17643115
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19214987
uniprot
proteins
pubmed
19487278
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23774213
uniprot
proteins
pubmed
24814316
uniprot
proteins
pubmed
28691764
uniprot
proteins
pubmed
28898622
uniprot
proteins
pubmed
30321615
uniprot
proteins
sequence_length
715
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:12154022, ECO:0000269|PubMed:17190795, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:24814316}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12154022}.
uniprot
proteins