CHST4
entrez
10164
canonical
uniprot
Q8NCG5
canonical
ensembl
ENSG00000140835
resolver
ensp
ENSP00000341206
resolver
ensp
ENSP00000441204
resolver
ensp
ENSP00000536651
resolver
ensp
ENSP00000597585
resolver
ensp
ENSP00000597586
resolver
enst
ENST00000338482
resolver
enst
ENST00000539698
resolver
enst
ENST00000866592
resolver
enst
ENST00000927526
resolver
enst
ENST00000927527
resolver
genesymbol
CHST4
resolver
hgnc
HGNC:1972
resolver
uniprot
Q8IV46
resolver
uniprot
Q9Y5R3
resolver
uniprot_entry
CHST4_HUMAN
resolver
uniprot_sec
Q8IV46
resolver
uniprot_sec
Q9Y5R3
resolver
amino_acid_sequence
MLLPKKMKLLLFLVSQMAILALFFHMYSHNISSLSMKAQPERMHVLVLSSWRSGSSFVGQLFGQHPDVFYLMEPAWHVWMTFKQSTAWMLHMAVRDLIRAVFLCDMSVFDAYMEPGPRRQSSLFQWENSRALCSAPACDIIPQDEIIPRAHCRLLCSQQPFEVVEKACRSYSHVVLKEVRFFNLQSLYPLLKDPSLNLHIVHLVRDPRAVFRSRERTKGDLMIDSRIVMGQHEQKLKKEDQPYYVMQVICQSQLEIYKTIQSLPKALQERYLLVRYEDLARAPVAQTSRMYEFVGLEFLPHLQTWVHNITRGKGMGDHAFHTNARDALNVSQAWRWSLPYEKVSRLQKACGDAMNLLGYRHVRSEQEQRNLLLDLLSTWTVPEQIH
uniprot
proteins
ec_number
2.8.2.-
uniprot
proteins
function
FUNCTION: Sulfotransferase involved in SELL/L-selectin ligand biosynthesis pathway. Catalyzes the transfer of the sulfate group from 3'-phospho-5'-adenylyl sulfate (PAPS) onto the hydroxyl group at C-6 position of the non-reducing N-acetylglucosamine (GlcNAc) residue within O-linked mucin-type glycans. Contributes to generate sialyl 6-sulfo Lewis X determinant (also known as MECA-79 epitope) for SELL recognition, a prerequisite for continuous lymphocyte homing into peripheral lymph nodes and antigen immune surveillance (PubMed:10330415, PubMed:11439191, PubMed:11726653, PubMed:12107080). Transfers the sulfate group primarily on core 2 GlcNAcbeta1-6(Galbeta1-3)GalNAcalphaSer/Thr and extended core 1 GlcNAcbeta1-3Galbeta1-3GalNAcalphaSer/Thr based O-linked glycans on CD34 and GLYCAM1 peripheral node addressins (PNAds) expressed on the lumenal side of high endothelial venules (HEVs) (PubMed:11439191). The recognition of PNAds by SELL initiates a multistep process comprising tethering and rolling of blood lymphocytes on HEVs against the blood flow, followed by chemokine signaling, integrin-mediated lymphocyte adhesion onto endothelial cells and lymphocyte transendothelial migration. Modulates rolling velocity and differential T and B lymphocyte recruitment into peripheral lymph nodes, with a major role in B lymphocyte homing. Might be redundant in sulfation of MADCAM1 and lymphocyte trafficking to mesenteric lymph nodes (By similarity). Can also sulfonate core 3 GlcNAcbeta1-3GalNAc-R based glycans as well as GlcNAcbeta1-3Galbeta1-Glc, GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharides, which might be ectopically expressed during tumorigenesis (PubMed:11439191, PubMed:11726653, PubMed:12107080). {ECO:0000250|UniProtKB:Q9R1I1, ECO:0000269|PubMed:10330415, ECO:0000269|PubMed:11439191, ECO:0000269|PubMed:11726653, ECO:0000269|PubMed:12107080}.
uniprot
proteins
mass_dalton
45134
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; carbohydrate sulfation. {ECO:0000269|PubMed:10330415, ECO:0000269|PubMed:11439191, ECO:0000269|PubMed:11726653, ECO:0000269|PubMed:12107080}.
uniprot
proteins
protein_family
Gal/GlcNAc/GalNAc subfamily
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
10330415
uniprot
proteins
pubmed
11181564
uniprot
proteins
pubmed
11310842
uniprot
proteins
pubmed
11439191
uniprot
proteins
pubmed
11726653
uniprot
proteins
pubmed
12107080
uniprot
proteins
pubmed
12855678
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15220337
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:12855678}; Single-pass type II membrane protein {ECO:0000269|PubMed:12855678}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins