Fshr
entrez
25449
canonical
uniprot
P20395
canonical
ensembl
ENSRNOG00000016783
resolver
ensembl
ENSRNOG00055019041
resolver
ensembl
ENSRNOG00060004359
resolver
ensembl
ENSRNOG00065007694
resolver
ensp
ENSRNOP00000022802
resolver
ensp
ENSRNOP00055026297
resolver
ensp
ENSRNOP00060005541
resolver
ensp
ENSRNOP00065008796
resolver
enst
ENSRNOT00000022802
resolver
enst
ENSRNOT00055032478
resolver
enst
ENSRNOT00060007308
resolver
enst
ENSRNOT00065012038
resolver
genesymbol
Fshr
resolver
uniprot
Q64183
resolver
uniprot_entry
FSHR_RAT
resolver
uniprot_sec
Q64183
resolver
amino_acid_sequence
MALLLVSLLAFLGTGSGCHHWLCHCSNRVFLCQDSKVTEIPTDLPRNAIELRFVLTKLRVIPKGSFAGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPSLRYLLISNTGIKHLPAVHKIQSLQKVLLDIQDNINIHIVARNSFMGLSFESVILWLSKNGIEEIHNCAFNGTQLDELNLSDNNNLEELPNDVFQGASGPVILDISRTKVHSLPNHGLENLKKLRARSTYRLKKLPNLDKFVTLMEASLTYPSHCCAFANLKRQISELHPICNKSILRQDIDDMTQIGDQRVSLIDDEPSYGKGSDMMYNEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNTTVLVVLTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASVMVLGWTFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMALLVLNVLAFVVICGCYTHIYLTVRNPTIVSSSSDTKIAKRMATLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQIYRTETSSATHNFHARKSHCSSAPRVTNSYVLVPLNHSSQN
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Mediates FSH signaling through cAMP/protein kinase A (PKA) and phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT) pathways to regulate ovarian follicular development and steroidogenesis (By similarity). Has diverse extragonadal functions: signals via a GNAI2-coupled FSHR on osteoclasts and their precursors, resulting in activation of MEK/ERK, NF-kappa-B, and AKT pathways and thus increases osteoclastogenesis and bone resorption (By similarity). Also regulates glucose-stimulated insulin secretion in pancreatic beta-cells in a bell curve manner, with moderate FSH levels promoting insulin secretion via Galphas/cAMP/PKA pathways while high FSH levels inhibit this effect through Galphai coupling (By similarity). In adipose tissue, inhibits thermogenesis by suppressing UCP1 expression and promotes lipogenesis via CREB/PPARgamma pathways (By similarity). Also affects hepatic cholesterol metabolism by increasing serum total and low-density-lipoprotein cholesterol (LDL-C) by inhibiting the expression of LDL receptor (LDLR) (By similarity). {ECO:0000250|UniProtKB:P23945, ECO:0000250|UniProtKB:P35378}.
uniprot
proteins
mass_dalton
77681
uniprot
proteins
mutagenesis
MUTAGEN 191; /note="N->Q: Reduces N-glycosylation level."; /evidence="ECO:0000269|PubMed:7776966"; MUTAGEN 199; /note="N->Q: Does not affect N-glycosylation level."; /evidence="ECO:0000269|PubMed:7776966"; MUTAGEN 293; /note="N->Q: Reduces N-glycosylation level."; /evidence="ECO:0000269|PubMed:7776966"; MUTAGEN 387; /note="T->I: Reduces interaction with ARRB2; when associated with I-389 and N-394."; /evidence="ECO:0000269|PubMed:12850288"; MUTAGEN 389; /note="S->I: Reduces interaction with ARRB2; when associated with I-387 and N-394."; /evidence="ECO:0000269|PubMed:12850288"; MUTAGEN 394; /note="T->N: Reduces interaction with ARRB2; when associated with I-387 and I-389."; /evidence="ECO:0000269|PubMed:12850288"; MUTAGEN 407; /note="D->N: Reduces interaction with ARRB2."; /evidence="ECO:0000269|PubMed:12850288"; MUTAGEN 548; /note="Y->F: Reduces interaction with ARRB2."; /evidence="ECO:0000269|PubMed:12850288
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone. {ECO:0000269|PubMed:7776966}.; PTM: Sulfated. {ECO:0000250|UniProtKB:P23945}.
uniprot
proteins
protein_family
FSH/LSH/TSH subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12850288
uniprot
proteins
pubmed
1738373
uniprot
proteins
pubmed
2126341
uniprot
proteins
pubmed
7776966
uniprot
proteins
sequence_length
692
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P23945}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23945}.
uniprot
proteins
transmembrane_region
TRANSMEM 366..386; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 398..420; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 443..464; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 485..507; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 528..549; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 573..596; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 608..629; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins