IL1R1
entrez
3554
canonical
uniprot
P14778
canonical
ensembl
ENSG00000115594
resolver
ensp
ENSP00000386380
resolver
ensp
ENSP00000386555
resolver
ensp
ENSP00000386776
resolver
ensp
ENSP00000523717
resolver
ensp
ENSP00000523718
resolver
ensp
ENSP00000523719
resolver
ensp
ENSP00000523720
resolver
ensp
ENSP00000523721
resolver
ensp
ENSP00000523722
resolver
ensp
ENSP00000523723
resolver
ensp
ENSP00000523724
resolver
ensp
ENSP00000523725
resolver
ensp
ENSP00000523726
resolver
ensp
ENSP00000523727
resolver
ensp
ENSP00000523729
resolver
ensp
ENSP00000523730
resolver
ensp
ENSP00000523731
resolver
ensp
ENSP00000523732
resolver
ensp
ENSP00000523733
resolver
ensp
ENSP00000523734
resolver
ensp
ENSP00000629811
resolver
ensp
ENSP00000629812
resolver
ensp
ENSP00000629814
resolver
ensp
ENSP00000629815
resolver
ensp
ENSP00000629816
resolver
ensp
ENSP00000629819
resolver
ensp
ENSP00000629820
resolver
ensp
ENSP00000629821
resolver
ensp
ENSP00000629822
resolver
ensp
ENSP00000629823
resolver
enst
ENST00000409929
resolver
enst
ENST00000410023
resolver
enst
ENST00000853658
resolver
enst
ENST00000853659
resolver
enst
ENST00000853660
resolver
enst
ENST00000853661
resolver
enst
ENST00000853662
resolver
enst
ENST00000853663
resolver
enst
ENST00000853664
resolver
enst
ENST00000853665
resolver
enst
ENST00000853666
resolver
enst
ENST00000853667
resolver
enst
ENST00000853668
resolver
enst
ENST00000853670
resolver
enst
ENST00000853671
resolver
enst
ENST00000853672
resolver
enst
ENST00000853673
resolver
enst
ENST00000853674
resolver
enst
ENST00000853675
resolver
enst
ENST00000959752
resolver
enst
ENST00000959753
resolver
enst
ENST00000959755
resolver
enst
ENST00000959756
resolver
enst
ENST00000959757
resolver
enst
ENST00000959760
resolver
enst
ENST00000959761
resolver
enst
ENST00000959762
resolver
enst
ENST00000959763
resolver
enst
ENST00000959764
resolver
genesymbol
IL1R1
resolver
genesymbol_syn
IL1R
resolver
genesymbol_syn
IL1RA
resolver
genesymbol_syn
IL1RT1
resolver
hgnc
HGNC:5993
resolver
uniprot
B8ZZW4
resolver
uniprot
Q587I7
resolver
uniprot_entry
B8ZZW4_HUMAN
resolver
uniprot_entry
IL1R1_HUMAN
resolver
uniprot_sec
Q587I7
resolver
amino_acid_sequence
MKVLLRLICFIALLISSLEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPVQRRSPSSKHQLLSPATKEKLQREAHVPLG
uniprot
proteins
disease_involvement
DISEASE: Chronic recurrent multifocal osteomyelitis 3 (CRMO3) [MIM:259680]: An autosomal dominant autoinflammatory bone disease characterized by early-childhood onset of bone pain and arthritis caused by sterile osteomyelitis. {ECO:0000269|PubMed:37315560}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: Receptor for IL1A, IL1B and IL1RN (PubMed:2950091, PubMed:37315560). After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850). {ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:10671496, ECO:0000269|PubMed:2950091, ECO:0000269|PubMed:37315560}.
uniprot
proteins
mass_dalton
65402
uniprot
proteins
mutagenesis
MUTAGEN 131; /note="K->D: Severely decreased interaction with IL1RN."; /evidence="ECO:0000269|PubMed:37315560"; MUTAGEN 131; /note="K->H: No effect on interaction with IL1RN."; /evidence="ECO:0000269|PubMed:37315560"; MUTAGEN 131; /note="K->R: No effect on interaction with IL1RN."; /evidence="ECO:0000269|PubMed:37315560"; MUTAGEN 369; /note="D->A: Reduces NF-kappa-B activation."; /evidence="ECO:0000269|PubMed:10671496"; MUTAGEN 428; /note="R->A: Reduces NF-kappa-B activation and receptor-associated kinase activation."; /evidence="ECO:0000269|PubMed:10671496
uniprot
proteins
post_translational_modification
PTM: A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding). {ECO:0000269|PubMed:8142597}.; PTM: Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1. {ECO:0000269|PubMed:9821957}.
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
10653850
uniprot
proteins
pubmed
10671496
uniprot
proteins
pubmed
10903327
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
2530587
uniprot
proteins
pubmed
2532321
uniprot
proteins
pubmed
2950091
uniprot
proteins
pubmed
37315560
uniprot
proteins
pubmed
7989776
uniprot
proteins
pubmed
8142597
uniprot
proteins
pubmed
9062193
uniprot
proteins
pubmed
9062194
uniprot
proteins
pubmed
9371760
uniprot
proteins
pubmed
9821957
uniprot
proteins
sequence_length
569
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:8142597}; Single-pass type I membrane protein {ECO:0000269|PubMed:8142597}. Cell membrane {ECO:0000305|PubMed:8142597}. Secreted {ECO:0000269|PubMed:8142597}.
uniprot
proteins
transmembrane_region
TRANSMEM 337..356; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins