KIF11
entrez
3832
canonical
uniprot
P52732
canonical
ensembl
ENSG00000138160
resolver
ensp
ENSP00000260731
resolver
enst
ENST00000260731
resolver
genesymbol
KIF11
resolver
genesymbol_syn
EG5
resolver
genesymbol_syn
KNSL1
resolver
genesymbol_syn
TRIP5
resolver
hgnc
HGNC:6388
resolver
uniprot
A0AV49
resolver
uniprot
B2RMV3
resolver
uniprot
Q15716
resolver
uniprot
Q5VWX0
resolver
uniprot_entry
KIF11_HUMAN
resolver
uniprot_sec
A0AV49
resolver
uniprot_sec
B2RMV3
resolver
uniprot_sec
Q15716
resolver
uniprot_sec
Q5VWX0
resolver
amino_acid_sequence
MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGKDKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
uniprot
proteins
disease_involvement
DISEASE: Microcephaly with or without chorioretinopathy, lymphedema, or impaired intellectual development (MCLMR) [MIM:152950]: An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes. {ECO:0000269|PubMed:22284827}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}.
uniprot
proteins
mass_dalton
119159
uniprot
proteins
mutagenesis
MUTAGEN 926; /note="T->A: No mitotic phosphorylation. No binding to spindle apparatus."; /evidence="ECO:0000269|PubMed:19001501"; MUTAGEN 1033; /note="S->A: Still binds to the mitotic spindle but mitotic progression is impaired."; /evidence="ECO:0000269|PubMed:19001501"; MUTAGEN 1033; /note="S->D: Still binds to the mitotic spindle but mitotic progression is impaired."; /evidence="ECO:0000269|PubMed:19001501"; MUTAGEN 1034; /note="K->R: Significantly diminished interaction with TPX2."; /evidence="ECO:0000269|PubMed:37728657
uniprot
proteins
post_translational_modification
PTM: Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:8548803}.; PTM: A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function. {ECO:0000269|PubMed:19001501}.; PTM: Ubiquitinated at Lys-1034 by UHRF1 via 'Lys-63'-linked ubiquitin chains, leading to interaction with spindle assembly factor TPX2, thereby ensuring accurate distribution to the spindles during metaphase. {ECO:0000269|PubMed:37728657}.
uniprot
proteins
protein_family
BimC subfamily
uniprot
proteins
protein_family
Kinesin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
11328809
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17707232
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19001501
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21303978
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22284827
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23857769
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
37728657
uniprot
proteins
pubmed
7776974
uniprot
proteins
pubmed
8548803
uniprot
proteins
pubmed
9701554
uniprot
proteins
sequence_length
1056
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:37728657}.
uniprot
proteins