RETREG2
entrez
79137
canonical
uniprot
Q8NC44
canonical
ensembl
ENSG00000144567
resolver
ensp
ENSP00000395249
resolver
enst
ENST00000430297
resolver
genesymbol
RETREG2
resolver
genesymbol_syn
C2orf17
resolver
genesymbol_syn
FAM134A
resolver
genesymbol_syn
MAG2
resolver
hgnc
HGNC:28450
resolver
uniprot
B3KR51
resolver
uniprot
Q6P1P5
resolver
uniprot
Q9H0K7
resolver
uniprot_entry
B3KR51_HUMAN
resolver
uniprot_entry
RETR2_HUMAN
resolver
uniprot_sec
Q6P1P5
resolver
uniprot_sec
Q9H0K7
resolver
amino_acid_sequence
MASGGGGGNTGAGGGPGMGLSLGLGLGLSLGMSEATSEAEEEAATAEAVGRLATTLWLRLRGWEAVLAAAQRLLVWEKPLHSLVTAAALNGLFWLLSSSSLRPFFLLSVSLLAYFLLDLWQPRFLPDVSASSPEEPHSDSEGAGSGARPHLLSVPELCRYLAESWLTFQIHLQELLQYKRQNPAQFCVRVCSGCAVLAVLGHYVPGIMISYIVLLSILLWPLVVYHELIQRMYTRLEPLLMQLDYSMKAEANALHHKHDKRKRQGKNAPPGGDEPLAETESESEAELAGFSPVVDVKKTALALAITDSELSDEEASILESGGFSVSRATTPQLTDVSEDLDQQSLPSEPEETLSRDLGEGEEGELAPPEDLLGRPQALSRQALDSEEEEEDVAAKETLLRLSSPLHFVNTHFNGAGSPPDGVKCSPGGPVETLSPETVSGGLTALPGTLSPPLCLVGSDPAPSPSILPPVPQDSPQPLPAPEEEEALTTEDFELLDQGELEQLNAELGLEPETPPKPPDAPPLGPDIHSLVQSDQEAQAVAEP
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}.
uniprot
proteins
mass_dalton
57830
uniprot
proteins
mutagenesis
MUTAGEN 492..495; /note="FELL->AELA: Abolishes interaction with ATG8 family proteins, induction of ER fragmentation and ER degradation."; /evidence="ECO:0000269|PubMed:34338405
uniprot
proteins
protein_family
RETREG family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26040720
uniprot
proteins
pubmed
34338405
uniprot
proteins
pubmed
34854256
uniprot
proteins
sequence_length
543
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:34338405}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins