TEAD1
entrez
7003
canonical
uniprot
P28347
canonical
ensembl
ENSG00000187079
resolver
ensp
ENSP00000435233
resolver
genesymbol
TEAD1
resolver
genesymbol_syn
TCF13
resolver
genesymbol_syn
TEF1
resolver
hgnc
HGNC:11714
resolver
uniprot
A4FUP2
resolver
uniprot
E7EV65
resolver
uniprot
Q59EF3
resolver
uniprot_entry
Q59EF3_HUMAN
resolver
uniprot_entry
TEAD1_HUMAN
resolver
uniprot_sec
A4FUP2
resolver
uniprot_sec
E7EV65
resolver
amino_acid_sequence
MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD
uniprot
proteins
disease_involvement
DISEASE: Sveinsson chorioretinal atrophy (SCRA) [MIM:108985]: Characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid. {ECO:0000269|PubMed:15016762, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:20123905}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
uniprot
proteins
mass_dalton
47946
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="K->R: Nearly abolished lactylation."; /evidence="ECO:0000269|PubMed:38512451"; MUTAGEN 421; /note="Y->A: Important loss of interaction with YAP1."; /evidence="ECO:0000269|PubMed:20123905
uniprot
proteins
post_translational_modification
PTM: Lactylation by AARS1 promotes nuclear localization and stabilization of YAP1, leading to increased Hippo signaling pathway (PubMed:38512451). Delactylated by SIRT1 (PubMed:38512451). {ECO:0000269|PubMed:38512451}.
uniprot
proteins
pubmed
15016762
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17085591
uniprot
proteins
pubmed
1851669
uniprot
proteins
pubmed
18579750
uniprot
proteins
pubmed
19324877
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20123905
uniprot
proteins
pubmed
2070413
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
38512451
uniprot
proteins
sequence_length
426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:38512451}.
uniprot
proteins