GZMA
entrez
3001
canonical
uniprot
P12544
canonical
ensembl
ENSG00000145649
resolver
ensp
ENSP00000274306
resolver
genesymbol
GZMA
resolver
genesymbol_syn
CTLA3
resolver
genesymbol_syn
HFSP
resolver
hgnc
HGNC:4708
resolver
uniprot
A4PHN1
resolver
uniprot
Q6IB36
resolver
uniprot_entry
GRAA_HUMAN
resolver
uniprot_sec
A4PHN1
resolver
uniprot_sec
Q6IB36
resolver
amino_acid_sequence
MRNSYRFLASSLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQVILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLMEKAKINKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWIIMTIKGAV
uniprot
proteins
ec_number
3.4.21.78
uniprot
proteins
function
FUNCTION: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:12819770, PubMed:32299851, PubMed:3257574, PubMed:3262682, PubMed:3263427). It cleaves after Lys or Arg (PubMed:12819770, PubMed:32299851). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death (PubMed:32299851, PubMed:34022140, PubMed:36157507, PubMed:36899106). Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity (PubMed:12524539). Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (PubMed:11555662, PubMed:12628186, PubMed:16818237). {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:12819770, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:32299851, ECO:0000269|PubMed:3257574, ECO:0000269|PubMed:3262682, ECO:0000269|PubMed:3263427, ECO:0000269|PubMed:34022140, ECO:0000269|PubMed:36157507, ECO:0000269|PubMed:36899106}.
uniprot
proteins
mass_dalton
28999
uniprot
proteins
mutagenesis
MUTAGEN 212; /note="S->A: Abolished protease activity."; /evidence="ECO:0000269|PubMed:32299851
uniprot
proteins
protein_family
Granzyme subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
11555662
uniprot
proteins
pubmed
12524539
uniprot
proteins
pubmed
12628186
uniprot
proteins
pubmed
12819769
uniprot
proteins
pubmed
12819770
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16818237
uniprot
proteins
pubmed
17180578
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
20038786
uniprot
proteins
pubmed
3047119
uniprot
proteins
pubmed
32299851
uniprot
proteins
pubmed
3237717
uniprot
proteins
pubmed
3257574
uniprot
proteins
pubmed
3262682
uniprot
proteins
pubmed
3263427
uniprot
proteins
pubmed
34022140
uniprot
proteins
pubmed
36157507
uniprot
proteins
pubmed
36899106
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform alpha]: Secreted {ECO:0000269|PubMed:3257574}. Cytoplasmic granule {ECO:0000269|PubMed:3257574}. Note=Delivered into the target cell by perforin. {ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:32299851}.
uniprot
proteins