PAWR
entrez
5074
canonical
uniprot
Q96IZ0
canonical
ensembl
ENSG00000177425
resolver
ensp
ENSP00000328088
resolver
ensp
ENSP00000573419
resolver
ensp
ENSP00000582139
resolver
ensp
ENSP00000582140
resolver
ensp
ENSP00000640702
resolver
ensp
ENSP00000745488
resolver
ensp
ENSP00000745490
resolver
enst
ENST00000328827
resolver
enst
ENST00000903360
resolver
enst
ENST00000912080
resolver
enst
ENST00000912081
resolver
enst
ENST00000970643
resolver
genesymbol
PAWR
resolver
genesymbol_syn
PAR4
resolver
hgnc
HGNC:8614
resolver
uniprot
O75796
resolver
uniprot
Q6FHY9
resolver
uniprot
Q8N700
resolver
uniprot_entry
PAWR_HUMAN
resolver
uniprot_sec
O75796
resolver
uniprot_sec
Q6FHY9
resolver
uniprot_sec
Q8N700
resolver
amino_acid_sequence
MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGGGSSDAAGKPPAGALGTPAAAAANELNNNLPGGAPAAPAVPGPGGVNCAVGSAMLTRAAPGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEPPRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDIEDENEQLKQENKTLLKVVGQLTR
uniprot
proteins
function
FUNCTION: Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}.
uniprot
proteins
mass_dalton
36568
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="A->D: No loss of interaction with SPSB1, SPSB2 and SPSB4."; /evidence="ECO:0000269|PubMed:20561531"; MUTAGEN 68; /note="E->D: Increased interaction with SPSB2. Only slightly increased interaction with SPSB4. Increased interaction with SPSB1, SPSB2 and SPSB4; when associated with A-69."; /evidence="ECO:0000269|PubMed:20561531"; MUTAGEN 69; /note="L->I: Only slightly increased interaction with SPSB2. Only slightly increased interaction with SPSB4. Increased interaction with SPSB1, SPSB2 and SPSB4; when associated with A-68."; /evidence="ECO:0000269|PubMed:20561531"; MUTAGEN 71; /note="N->A: Loss of interaction with SPSB1, SPSB2 and SPSB4."; /evidence="ECO:0000269|PubMed:20561531"; MUTAGEN 72; /note="N->A: Loss of interaction with SPSB1-Elongin BC complex and SPSB2 and SPSB4."; /evidence="ECO:0000269|PubMed:17189197, ECO:0000269|PubMed:20561531
uniprot
proteins
post_translational_modification
PTM: Preferentially phosphorylated at the Thr-163 by PKC in cancer cells. {ECO:0000250}.
uniprot
proteins
pubmed
11585763
uniprot
proteins
pubmed
11755531
uniprot
proteins
pubmed
12242017
uniprot
proteins
pubmed
12565819
uniprot
proteins
pubmed
12717420
uniprot
proteins
pubmed
14627703
uniprot
proteins
pubmed
14755681
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15671026
uniprot
proteins
pubmed
17189197
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20561531
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8943350
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies. {ECO:0000250}.
uniprot
proteins