GALNT13
entrez
114805
canonical
uniprot
Q8IUC8
canonical
ensembl
ENSG00000144278
resolver
ensp
ENSP00000376570
resolver
ensp
ENSP00000387239
resolver
ensp
ENSP00000561987
resolver
ensp
ENSP00000604872
resolver
ensp
ENSP00000604875
resolver
ensp
ENSP00000604877
resolver
genesymbol
GALNT13
resolver
genesymbol_syn
KIAA1918
resolver
hgnc
HGNC:23242
resolver
uniprot
A0A1L4BJA8
resolver
uniprot
B3KY85
resolver
uniprot
Q08ER7
resolver
uniprot
Q68VI8
resolver
uniprot
Q6ZWG1
resolver
uniprot
Q96PX0
resolver
uniprot
Q9UIE5
resolver
uniprot_entry
A0A1L4BJA8_HUMAN
resolver
uniprot_entry
B3KY85_HUMAN
resolver
uniprot_entry
GLT13_HUMAN
resolver
uniprot_sec
Q08ER7
resolver
uniprot_sec
Q68VI8
resolver
uniprot_sec
Q6ZWG1
resolver
uniprot_sec
Q96PX0
resolver
uniprot_sec
Q9UIE5
resolver
amino_acid_sequence
MRRFVYCKVVLATSLMWVLVDVFLLLYFSECNKCDDKKERSLLPALRAVISRNQEGPGEMGKAVLIPKDDQEKMKELFKINQFNLMASDLIALNRSLPDVRLEGCKTKVYPDELPNTSVVIVFHNEAWSTLLRTVYSVINRSPHYLLSEVILVDDASERDFLKLTLENYVKNLEVPVKIIRMEERSGLIRARLRGAAASKGQVITFLDAHCECTLGWLEPLLARIKEDRKTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRNYFEEIGTYDAGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYTFPGGTGHVINKNNRRLAEVWMDEFKDFFYIISPGVVKVDYGDVSVRKTLRENLKCKPFSWYLENIYPDSQIPRRYYSLGEIRNVETNQCLDNMGRKENEKVGIFNCHGMGGNQVFSYTADKEIRTDDLCLDVSRLNGPVIMLKCHHMRGNQLWEYDAERLTLRHVNSNQCLDEPSEEDKMVPTMQDCSGSRSQQWLLRNMTLGT
uniprot
proteins
ec_number
2.4.1.41
uniprot
proteins
function
FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor (PubMed:12407114, PubMed:22186971). Generates GalNAc-O-Ser/Thr structure also known as Tn antigen, which itself is immunogenic but also serves as a precursor for the synthesis of different mucin-type O-glycan core structures (PubMed:12407114). Contributes to the synthesis of O-linked glycans on mucins and proteoglycans of the central nervous system. May promote neurogenesis through glycosylation and stabilization of PDPN (By similarity) (PubMed:12407114, PubMed:22186971). {ECO:0000250|UniProtKB:Q8CF93, ECO:0000269|PubMed:12407114, ECO:0000269|PubMed:22186971}.; FUNCTION: [Isoform 1]: Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar. Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC, specifically on Thr-3 of non-glycosylated MUC5AC peptide, on Thr-12 and Thr-13 of preglycosylated MUC5AC at Thr-3 (MUC5AC-3), on Thr-3 of preglycosylated MUC5AC at Thr-13 (MUC5AC-13) and on Thr-12 of preglycosylated MUC5AC at Thr-3 and Thr-13 (MUC5AC-3,13). Transfers GalNAc to three consecutive serine/threonine residues on SDC3 forming a triplet-Tn epitope expressed in Purkinje cells of the developing brain. {ECO:0000269|PubMed:12407114, ECO:0000269|PubMed:22186971}.; FUNCTION: [Isoform 4]: Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar. Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC, specifically on Thr-3 of non-glycosylated MUC5AC peptide, on Thr-12 and Thr-13 of preglycosylated MUC5AC at Thr-3 (MUC5AC-3), on Thr-3 of preglycosylated MUC5AC at Thr-13 (MUC5AC-13) and on Thr-12 of preglycosylated MUC5AC at Thr-3 and Thr-13 (MUC5AC-3,13). {ECO:0000269|PubMed:22186971}.
uniprot
proteins
mass_dalton
64051
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000305|PubMed:12407114, ECO:0000305|PubMed:22186971}.
uniprot
proteins
protein_family
GalNAc-T subfamily
uniprot
proteins
protein_family
Glycosyltransferase 2 family
uniprot
proteins
pubmed
11572484
uniprot
proteins
pubmed
12407114
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
22186971
uniprot
proteins
pubmed
24722188
uniprot
proteins
pubmed
25715345
uniprot
proteins
sequence_length
556
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..27; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins