Dkkl1
entrez
50722
canonical
uniprot
Q9QZL9
canonical
ensembl
ENSMUSG00000030792
resolver
ensp
ENSMUSP00000033057
resolver
ensp
ENSMUSP00000147678
resolver
enst
ENSMUST00000033057
resolver
enst
ENSMUST00000210741
resolver
genesymbol
Dkkl1
resolver
genesymbol_syn
Sgy1
resolver
uniprot
A0A1B0GRV4
resolver
uniprot
Q3V2N2
resolver
uniprot
Q9EQT4
resolver
uniprot
Q9ERW0
resolver
uniprot
Q9ERW1
resolver
uniprot_entry
A0A1B0GRV4_MOUSE
resolver
uniprot_entry
DKKL1_MOUSE
resolver
uniprot_entry
Q3V2N2_MOUSE
resolver
uniprot_sec
Q9EQT4
resolver
uniprot_sec
Q9ERW0
resolver
uniprot_sec
Q9ERW1
resolver
amino_acid_sequence
MCRLRVLLLLLPLAFVSSSALPIHDVDSQQNTSGFLGLQRLLQSFSRLFLKNDLLRDLDNFFSSPMDFRDLPRNFHQEENQEHRMGNHTLSSHLQIDKVTDNQTGEVLISEKVEASIEPERNPEGDWKVPKVEAKEPPVPVQKVTDSLHPEPRQVAFWIMKMPRRRTQPDVQDGGRWLIEKRHRMQAIRDGLRGGAREDSLEDGVHIPQHAKLPVRKTHFLYILRPSQQL
uniprot
proteins
function
FUNCTION: Involved in fertilization by facilitating sperm penetration of the zona pellucida (PubMed:19596312, PubMed:22817830). May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells (PubMed:18818293). Is not essential either for development or fertility (PubMed:19596310). {ECO:0000269|PubMed:18818293, ECO:0000269|PubMed:19596310, ECO:0000269|PubMed:19596312, ECO:0000269|PubMed:22817830}.
uniprot
proteins
mass_dalton
26639
uniprot
proteins
post_translational_modification
PTM: N-glycosylated during spermatogenesis. Not N-glycosylated in mature sperm. {ECO:0000269|PubMed:15892050, ECO:0000269|PubMed:19596310}.
uniprot
proteins
pubmed
10570958
uniprot
proteins
pubmed
11024178
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15892050
uniprot
proteins
pubmed
18818293
uniprot
proteins
pubmed
19176879
uniprot
proteins
pubmed
19596310
uniprot
proteins
pubmed
19596312
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21698294
uniprot
proteins
pubmed
22817830
uniprot
proteins
pubmed
27550540
uniprot
proteins
sequence_length
230
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:15892050, ECO:0000269|PubMed:19176879}. Note=Localized specifically to the crescent shaped acrosome at the apex of the sperm head. {ECO:0000269|PubMed:15892050}.
uniprot
proteins