Pus7
entrez
78697
canonical
uniprot
Q91VU7
canonical
ensembl
ENSMUSG00000057541
resolver
ensp
ENSMUSP00000113801
resolver
ensp
ENSMUSP00000114588
resolver
ensp
ENSMUSP00000123129
resolver
ensp
ENSMUSP00000313555
resolver
ensp
ENSMUSP00000343040
resolver
genesymbol
Pus7
resolver
genesymbol_syn
Kiaa1897
resolver
uniprot
B7ZNL8
resolver
uniprot
F7AC41
resolver
uniprot
Q3TUC7
resolver
uniprot
Q3ULP8
resolver
uniprot
Q3UQN6
resolver
uniprot
Q69Z76
resolver
uniprot_entry
PUS7_MOUSE
resolver
uniprot_entry
Q3ULP8_MOUSE
resolver
uniprot_sec
B7ZNL8
resolver
uniprot_sec
F7AC41
resolver
uniprot_sec
Q3TUC7
resolver
uniprot_sec
Q3UQN6
resolver
uniprot_sec
Q69Z76
resolver
amino_acid_sequence
MEMTSTSLKRGCLVVEDNDSVTPHDETKKQKVSEGCLTSSQDGVENDGLHRSENEPGPPEAESTVKDDENSSAQVQEEEEEEEEEDGLSEAGEEEEAESFADMMKHGLTELDVGICKFVSSHHGFSGILKERYSDFVVHEIGKDGRISHLDDLSVPVDEEDPPEDALTVLTAEDRQQLEELQLFKNKETSVAIEVIEDTKEKRTVIHQAIKSLFPGLETKTEDREGRKYIVAYHAAGKKALANPRKHSWPKSRGSYCHFVLYKENKDTMDAINVLSKYLRVKPNIFSYMGTKDKRAITVQEIAVLKISAQRLAHLNKCLMNLKLGNFSYQKTPLKLGALQGNHFTVVLRNITGTDEQVQQAMQSLRETGFINYYGMQRFGTTAVPTYQVGRAILQNSWTEVMDLILKPRSGAEKGYLVKCREEWAKTKDPASALKKLPVKRCVEGQLLRGLSRYGMKNIVSAFGIIPRNNRLMYIHSYQSYVWNTMVSRRIEEYGLRPVPGDLVLKGATPTYIEEDDVDNYSIHDVVMPLPGFDVIYPKHKISEAYREMLAADNLDIDNMRHTIRDYSLSGAYRRIIIRPQSVSWEVVAYDDPKIPLFNTDVDNLEGKPPPVFASEGKYRALKMDFSLPPSTYATMAIREVLKMDTSIKNQTQLNTSWLR
uniprot
proteins
ec_number
5.4.99.-
uniprot
proteins
function
FUNCTION: Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types. {ECO:0000250|UniProtKB:Q96PZ0}.
uniprot
proteins
mass_dalton
74793
uniprot
proteins
protein_family
Pseudouridine synthase TruD family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
660
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96PZ0}.
uniprot
proteins