Fbxw7
entrez
100360914
canonical
uniprot
D3Z902
canonical
ensembl
ENSRNOG00000010889
resolver
ensembl
ENSRNOG00055023861
resolver
ensembl
ENSRNOG00060031911
resolver
ensembl
ENSRNOG00065027460
resolver
ensp
ENSRNOP00000015280
resolver
ensp
ENSRNOP00000050193
resolver
ensp
ENSRNOP00000074892
resolver
ensp
ENSRNOP00000090758
resolver
ensp
ENSRNOP00055033273
resolver
ensp
ENSRNOP00060045793
resolver
ensp
ENSRNOP00065038842
resolver
enst
ENSRNOT00000015279
resolver
enst
ENSRNOT00000052051
resolver
enst
ENSRNOT00000081678
resolver
enst
ENSRNOT00000116921
resolver
enst
ENSRNOT00055040942
resolver
enst
ENSRNOT00060055349
resolver
enst
ENSRNOT00065047356
resolver
genesymbol
Fbxw7
resolver
genesymbol_syn
LOC100360914
resolver
uniprot
A0A0G2K979
resolver
uniprot
A0A8I6AED9
resolver
uniprot
D3ZQU4
resolver
uniprot_entry
A0A0G2K979_RAT
resolver
uniprot_entry
A0A8I6AED9_RAT
resolver
uniprot_entry
D3ZQU4_RAT
resolver
uniprot_entry
FBXW7_RAT
resolver
amino_acid_sequence
MNQELLSVGSKRRRTGGSLRGNASSSQVDEEQMNRVVEEDPQQQPRHQEEEHTARNGELVGADPRPGAQNDSQQGQVEENNNRFVSVDEDSSGNQEEQEEDEEHAGEQEEEEEEEEEEEEEEEMDQESDDFDQSDDSSREDEHTHNSNVTNCTSVVDLPINQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSDYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKIIKPGFIHSPWKSAYIRQHRIDTNWRRGELRSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPSKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, MLST8, RICTOR and probably PSEN1 (By similarity). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (By similarity). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (By similarity). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (By similarity). Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage (By similarity). The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining (By similarity). {ECO:0000250|UniProtKB:Q8VBV4, ECO:0000250|UniProtKB:Q969H0}.
uniprot
proteins
mass_dalton
80367
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q969H0}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-211 promotes interaction with PIN1, leading to disrupt FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation. Phosphorylated by ATM at Ser-26 in response to DNA damage, promoting recruitment to DNA damage sites and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4. {ECO:0000250|UniProtKB:Q969H0}.; PTM: Ubiquitinated: autoubiquitinates following phosphorylation at Thr-211 and subsequent interaction with PIN1. Ubiquitination leads to its degradation. {ECO:0000250|UniProtKB:Q969H0}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
27458189
uniprot
proteins
sequence_length
713
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q969H0}. Chromosome {ECO:0000250|UniProtKB:Q969H0}. Note=Localizes to site of double-strand breaks following phosphorylation by ATM. {ECO:0000250|UniProtKB:Q969H0}.
uniprot
proteins