Ralbp1
entrez
19765
canonical
uniprot
Q62172
canonical
ensembl
ENSMUSG00000024096
resolver
ensp
ENSMUSP00000024905
resolver
ensp
ENSMUSP00000129448
resolver
ensp
ENSMUSP00000323331
resolver
ensp
ENSMUSP00000323341
resolver
enst
ENSMUST00000024905
resolver
enst
ENSMUST00000166543
resolver
genesymbol
Ralbp1
resolver
genesymbol_syn
Rip1
resolver
uniprot
Q6NXH5
resolver
uniprot
Q9CRE5
resolver
uniprot_entry
RBP1_MOUSE
resolver
uniprot_sec
Q6NXH5
resolver
uniprot_sec
Q9CRE5
resolver
amino_acid_sequence
MTECFLPPSSSPSEHRRAEHGSGLTRTPSSEEISPTKFPGLYRTGEPSPPHDVLHEPPDTVSDDDKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESPSKVKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEEKHKEEKHKEKKSKDLTAADVVKQWKEKKKKKKPIQEPEVPQMDAPSVKPIFGVPLVDAVERTMMYDGVRLPAVFRECVDYMEKHGMKCEGVYRVSGIKSKVDELKAAYDREESPNLEEYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGKTTEMEKVQEFQRLLRELPECNHLLLSWLIVHLDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVLFTHVQELFGTVVLKQVTRPLRWSNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQECETKIAQEIASLSKEDVSKEEMNENEEVINILLAQENEILTEQEELLAMEQFLRRQIASEKEEIDRLRAEIAEIQSRQQHGRSETEEYSSDSESESEDEEELQLILEDLQRQNEELEIKNNHLNQAVHEEREAIIELRVQLRLLQMQRAKSEQQPQEEEEPERRGGIGPPPCDGVLEVRVAKEQAKASPSKDRKETPI
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
ec_number
7.6.2.3
uniprot
proteins
function
FUNCTION: Multifunctional protein that functions as a downstream effector of RALA and RALB. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:8570186). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis. During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of RALA. Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (By similarity). {ECO:0000250|UniProtKB:Q15311, ECO:0000269|PubMed:8570186}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000250|UniProtKB:Q15311}.
uniprot
proteins
mass_dalton
75043
uniprot
proteins
post_translational_modification
PTM: Tyrosine-phosphorylated upon stimulation of cells with EGF. {ECO:0000305|PubMed:9395447}.; PTM: May undergo proteolytic cleavage to give peptides which reassemble to form a transporter complex. {ECO:0000250|UniProtKB:Q15311}.
uniprot
proteins
pubmed
10910768
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8570186
uniprot
proteins
pubmed
9395447
uniprot
proteins
sequence_length
648
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q15311}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15311}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q15311}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q62796}. Nucleus {ECO:0000250|UniProtKB:Q15311}. Mitochondrion {ECO:0000250|UniProtKB:Q15311}. Note=Cytosolic protein that transiently associates with the mitotic spindle poles in early prophase, and dissociates from them after completion of mitosis (By similarity). Targeted to the plasma membrane through its interaction with RALB, directed by FGF signaling. Docking on the membrane is required to transduce the Ral signal (By similarity). Recruited by RALA to the mitochondrion during mitosis where it regulates mitochondrial fission. Nuclear localization is cell cycle dependent while membrane localization is seen in adherent cells. The region involved in membrane association could form transmembrane domains and expose a part of the protein extracellularly (By similarity). {ECO:0000250|UniProtKB:Q15311, ECO:0000250|UniProtKB:Q62796, ECO:0000250|UniProtKB:Q9PT60}.
uniprot
proteins