Svip
entrez
499157
canonical
uniprot
P0C0A9
canonical
ensembl
ENSRNOG00000037137
resolver
ensp
ENSRNOP00000052878
resolver
enst
ENSRNOT00000056024
resolver
genesymbol
Svip
resolver
uniprot_entry
SVIP_RAT
resolver
amino_acid_sequence
MGLCFPCPAESAPPSPSPEEKRAKLAEAAERRQKEAASRGILDIQSVEAKKKKKEQLEKQMETSGPPAGGLRWTVS
uniprot
proteins
function
FUNCTION: Negative regulator of the ER-associated degradation pathway (ERAD) of misfolded proteins. It competes with AMFR/gp78 for binding VCP/p97, and inhibits AMFR/gp78-VCP/p97 complex formation that is required for degradation of ERAD substrates. Involved in the regulation of adrenal cortisol and dehydroepiandrosterone (DHEA) biosynthesis. {ECO:0000250|UniProtKB:Q8NHG7}.
uniprot
proteins
mass_dalton
8248
uniprot
proteins
protein_family
SVIP family
uniprot
proteins
pubmed
12529442
uniprot
proteins
pubmed
35042898
uniprot
proteins
sequence_length
76
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8NHG7}; Lipid-anchor {ECO:0000250|UniProtKB:Q8NHG7}. Smooth endoplasmic reticulum membrane {ECO:0000269|PubMed:12529442}; Peripheral membrane protein {ECO:0000269|PubMed:12529442}. Golgi apparatus membrane {ECO:0000269|PubMed:12529442}; Peripheral membrane protein {ECO:0000269|PubMed:12529442}. Cell membrane {ECO:0000269|PubMed:12529442}; Peripheral membrane protein {ECO:0000269|PubMed:12529442}. Lysosome membrane {ECO:0000250|UniProtKB:Q8NHG7}.
uniprot
proteins