HTR3B
entrez
9177
canonical
uniprot
O95264
canonical
ensembl
ENSG00000149305
resolver
ensp
ENSP00000260191
resolver
ensp
ENSP00000443118
resolver
genesymbol
HTR3B
resolver
hgnc
HGNC:5298
resolver
uniprot
B0YJ23
resolver
uniprot
Q0VJC3
resolver
uniprot_entry
5HT3B_HUMAN
resolver
uniprot_sec
B0YJ23
resolver
uniprot_sec
Q0VJC3
resolver
amino_acid_sequence
MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWALWGGV
uniprot
proteins
function
FUNCTION: Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons. {ECO:0000269|PubMed:10521471, ECO:0000269|PubMed:12867984, ECO:0000269|PubMed:17392525, ECO:0000269|PubMed:9950429}.
uniprot
proteins
mass_dalton
50292
uniprot
proteins
mutagenesis
MUTAGEN 52; /note="N->S: Reduced molecular weight. Very little expression in the cell membrane."; /evidence="ECO:0000269|PubMed:21138434"; MUTAGEN 96; /note="N->S: Reduced molecular weight. Very little expression in the cell membrane."; /evidence="ECO:0000269|PubMed:21138434"; MUTAGEN 138; /note="N->S: Reduced molecular weight. Very little expression in the cell membrane."; /evidence="ECO:0000269|PubMed:21138434"; MUTAGEN 168; /note="N->S: Reduced molecular weight and cell membrane expression."; /evidence="ECO:0000269|PubMed:21138434"; MUTAGEN 203; /note="N->S: Reduced molecular weight. Very little expression in the cell membrane."; /evidence="ECO:0000269|PubMed:21138434
uniprot
proteins
post_translational_modification
PTM: N-glycosylation required for membrane localization. {ECO:0000269|PubMed:21138434}.
uniprot
proteins
protein_family
5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily
uniprot
proteins
protein_family
HTR3B sub-subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
10521471
uniprot
proteins
pubmed
12867984
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15293096
uniprot
proteins
pubmed
15389765
uniprot
proteins
pubmed
16487942
uniprot
proteins
pubmed
17010535
uniprot
proteins
pubmed
17392525
uniprot
proteins
pubmed
21138434
uniprot
proteins
pubmed
21179162
uniprot
proteins
pubmed
9950429
uniprot
proteins
sequence_length
441
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:9950429}; Multi-pass membrane protein {ECO:0000269|PubMed:21138434}. Cell membrane {ECO:0000269|PubMed:21138434}; Multi-pass membrane protein {ECO:0000269|PubMed:21138434}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. {ECO:0000269|PubMed:21138434}.
uniprot
proteins
transmembrane_region
TRANSMEM 239..259; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 269..286; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 304..324; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 415..435; /note="Helical; Name=4"; /evidence="ECO:0000255
uniprot
proteins