PNN
entrez
5411
canonical
uniprot
Q9H307
canonical
ensembl
ENSG00000100941
resolver
ensp
ENSP00000216832
resolver
enst
ENST00000216832
resolver
genesymbol
PNN
resolver
genesymbol_syn
DRS
resolver
genesymbol_syn
MEMA
resolver
hgnc
HGNC:9162
resolver
uniprot
B4DZX8
resolver
uniprot
O60899
resolver
uniprot
Q53EM7
resolver
uniprot
Q6P5X4
resolver
uniprot
Q7KYL1
resolver
uniprot
Q99738
resolver
uniprot
Q9UHZ9
resolver
uniprot
Q9UQR9
resolver
uniprot_entry
PININ_HUMAN
resolver
uniprot_sec
B4DZX8
resolver
uniprot_sec
O60899
resolver
uniprot_sec
Q53EM7
resolver
uniprot_sec
Q6P5X4
resolver
uniprot_sec
Q7KYL1
resolver
uniprot_sec
Q99738
resolver
uniprot_sec
Q9UHZ9
resolver
uniprot_sec
Q9UQR9
resolver
amino_acid_sequence
MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRRGFSDSGGGPPAKQRDLEGAVSRLGGERRTRRESRQESDPEDDDVKKPALQSSVVATSKERTRRDLIQDQNMDEKGKQRNRRIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLEQKVELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQRKMNALFEGRRIEFAEQINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVAQREEELEETGNQHNDVEIEEAGEEEEKEIAIVHSDAEKEQEEEEQKQEMEVKMEEETEVRESEKQQDSQPEEVMDVLEMVENVKHVIADQEVMETNRVESVEPSENEASKELEPEMEFEIEPDKECKTLSPGKENVSALDMEKESEEKEEKESEPQPEPVAQPQPQSQPQLQLQSQSQPVLQSQPPSQPEDLSLAVLQPTPQVTQEQGHLLPERKDFPVESVKLTEVPVEPVLTVHPESKSKTKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRDTKGSKDKNSRSDRKRSISESSRSGKRSSRSERDRKSDRKDKRR
uniprot
proteins
function
FUNCTION: Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma. {ECO:0000269|PubMed:12051732, ECO:0000269|PubMed:14517304, ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:15735603, ECO:0000269|PubMed:22388736}.
uniprot
proteins
mass_dalton
81628
uniprot
proteins
mutagenesis
MUTAGEN 8; /note="L->P: Abolishes interaction with KRT18."; /evidence="ECO:0000269|PubMed:10809736"; MUTAGEN 19; /note="L->P: Abolishes interaction with KRT18."; /evidence="ECO:0000269|PubMed:10809736"; MUTAGEN 502..503; /note="PE->AA: Abolishes interaction with CTBP1 and shows moderate relief of CTBP1-mediated repression."; /evidence="ECO:0000269|PubMed:15542832
uniprot
proteins
protein_family
Pinin family
uniprot
proteins
pubmed
10095061
uniprot
proteins
pubmed
10486276
uniprot
proteins
pubmed
10645008
uniprot
proteins
pubmed
10809736
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
12051732
uniprot
proteins
pubmed
12893261
uniprot
proteins
pubmed
14517304
uniprot
proteins
pubmed
14578391
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14729963
uniprot
proteins
pubmed
15358154
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15542832
uniprot
proteins
pubmed
15735603
uniprot
proteins
pubmed
16314458
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22388736
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
8922384
uniprot
proteins
pubmed
9447706
uniprot
proteins
sequence_length
717
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle. Cell junction, desmosome. Note=Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
uniprot
proteins