RDX
entrez
5962
canonical
uniprot
P35241
canonical
ensembl
ENSG00000137710
resolver
ensp
ENSP00000432112
resolver
ensp
ENSP00000433580
resolver
ensp
ENSP00000436277
resolver
ensp
ENSP00000445826
resolver
ensp
ENSP00000496414
resolver
ensp
ENSP00000496503
resolver
ensp
ENSP00000584291
resolver
ensp
ENSP00000707322
resolver
ensp
ENSP00000707325
resolver
genesymbol
RDX
resolver
hgnc
HGNC:9944
resolver
uniprot
A7YIJ8
resolver
uniprot
A7YIK0
resolver
uniprot
A7YIK3
resolver
uniprot
B0YJ88
resolver
uniprot
B7Z9U6
resolver
uniprot
F5H1A7
resolver
uniprot
Q6PKD3
resolver
uniprot
Q86Y61
resolver
uniprot_entry
B0YJ88_HUMAN
resolver
uniprot_entry
Q6PKD3_HUMAN
resolver
uniprot_entry
RADI_HUMAN
resolver
uniprot_sec
A7YIJ8
resolver
uniprot_sec
A7YIK0
resolver
uniprot_sec
A7YIK3
resolver
uniprot_sec
B7Z9U6
resolver
uniprot_sec
F5H1A7
resolver
uniprot_sec
Q86Y61
resolver
activity_regulation
ACTIVITY REGULATION: A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM
uniprot
proteins
disease_involvement
DISEASE: Deafness, autosomal recessive, 24 (DFNB24) [MIM:611022]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269|PubMed:17226784}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
uniprot
proteins
mass_dalton
68564
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17226784
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8486357
uniprot
proteins
pubmed
9430655
uniprot
proteins
sequence_length
583
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cell projection, microvillus {ECO:0000250|UniProtKB:P26043}. Cell projection, stereocilium {ECO:0000250|UniProtKB:P26043}. Note=Enriched at the stereocilium base with very low levels in the shaft of stereociliary bundles (By similarity). Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively. {ECO:0000250|UniProtKB:P26043}.
uniprot
proteins