P2rx5
entrez
94045
canonical
uniprot
Q91VE2
canonical
ensembl
ENSMUSG00000005950
resolver
ensp
ENSMUSP00000006104
resolver
ensp
ENSMUSP00000247217
resolver
ensp
ENSMUSP00000364142
resolver
enst
ENSMUST00000006104
resolver
genesymbol
P2rx5
resolver
uniprot
B9EHM6
resolver
uniprot
Q3UYI1
resolver
uniprot_entry
P2RX5_MOUSE
resolver
uniprot_sec
B9EHM6
resolver
uniprot_sec
Q3UYI1
resolver
activity_regulation
ACTIVITY REGULATION: Activated by ATP (PubMed:11404011). Slowly desensitizing. Not activated by ATP agonist alpha/beta-methylene-ATP. Highly sensitive to the antagonists suramin and PPADS (By similarity). {ECO:0000250|UniProtKB:P51578, ECO:0000269|PubMed:11404011}.
uniprot
proteins
amino_acid_sequence
MGQAAWKGFVLSLFDYKTAKFVVAKSKKVGLLYRVLQLTILLYLLIWVFLIKKSYQDIDTSLQSAVVTKVKGVAYTNTTMLGERLWDVADFVIPSQGENVFFVVTNLIVTPNQRQGICAEREGIPDGECSEDTDCHAGESVVAGHGLKTGRCLRVGNSTRGTCEIFAWCPVETKSMPTDPLLKDAEGFTIFIKNFIRFPKFNFSKANVLETGNKHFLKTCHFSSTNLYCPIFRLGSIVRWAGADFQDIALKGGVIGIHIEWDCDLDKAASHCNPHYYFNRLDNKHTQSISSGYNFRFARYYRDPHGVEFRDLMKAYGIRFDVIVNGKAGKFSIIPTVINIGSGLALMGAGAFFCDLVLIYLIRKSEFYRDKKFEKVRGQKEEDNVEVEANEMEQELPEDKPLERVHQDEQALELAQSGRKQNSNCQVLFEPARSGLQENAFVNMKPSQILQTVKT
uniprot
proteins
function
FUNCTION: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:11404011, PubMed:36940138). Unlike other P2RX receptors, the P2X5 receptor is also permeable to chloride (By similarity). Acts as an important regulator of inflammatory-related bone loss and osteoclast multinucleation (PubMed:28298636). {ECO:0000250|UniProtKB:Q93086, ECO:0000269|PubMed:11404011, ECO:0000269|PubMed:28298636, ECO:0000269|PubMed:36940138}.
uniprot
proteins
mass_dalton
51362
uniprot
proteins
mutagenesis
MUTAGEN 17; /note="K->E,D: Affects the relative permeability of cations to anions."; /evidence="ECO:0000269|PubMed:36940138
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
11404011
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
28298636
uniprot
proteins
pubmed
36940138
uniprot
proteins
sequence_length
455
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q93086}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..50; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P56373"; TRANSMEM 340..362; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P56373
uniprot
proteins