STRIT1
entrez
100507537
canonical
uniprot
P0DN84
canonical
ensembl
ENSG00000240045
resolver
ensp
ENSP00000489859
resolver
enst
ENST00000489090
resolver
genesymbol
STRIT1
resolver
genesymbol_syn
DWORF
resolver
hgnc
HGNC:52297
resolver
uniprot
A0A1B0GTW0
resolver
uniprot_entry
DWORF_HUMAN
resolver
uniprot_sec
A0A1B0GTW0
resolver
amino_acid_sequence
MAEKAGSTFSHLLVPILLLIGWIVGCIIMIYVVFS
uniprot
proteins
function
FUNCTION: Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity (By similarity). Also enhances the activity of the ATP2A2/SERCA2 ATPase (PubMed:33581112). Does not directly stimulate SERCA pump activity (By similarity). Binds preferentially to the phosphorylated E1 and E2 conformational forms of ATP2A2 which predominate at high Ca(2+) concentrations during the systolic phase of the cardiac cycle (By similarity). Competes with ATP2A2 inhibitor phospholamban (PLN) for binding to ATP2A2 and displaces PLN (PubMed:33581112). Can activate ATP2A2 directly in the absence of PLN (PubMed:33581112). Also enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN) and myoregulin (MRLN) (By similarity). {ECO:0000250|UniProtKB:P0DN83, ECO:0000269|PubMed:33581112}.
uniprot
proteins
mass_dalton
3836
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="P->A: Significant reduction in binding to ATP2A and reduced ATP2A2 activation; when associated with A-22."; /evidence="ECO:0000269|PubMed:33581112"; MUTAGEN 22; /note="W->A: Significant reduction in binding to ATP2A and reduced ATP2A2 activation; when associated with A-15."; /evidence="ECO:0000269|PubMed:33581112
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
26816378
uniprot
proteins
pubmed
33581112
uniprot
proteins
pubmed
36523160
uniprot
proteins
sequence_length
35
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P0DN83}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..34; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins