SLC39A2
entrez
29986
canonical
uniprot
Q9NP94
canonical
ensembl
ENSG00000165794
resolver
ensp
ENSP00000298681
resolver
ensp
ENSP00000452568
resolver
genesymbol
SLC39A2
resolver
genesymbol_syn
ZIP2
resolver
hgnc
HGNC:17127
resolver
uniprot
B2RC76
resolver
uniprot
G3V5X2
resolver
uniprot
Q4QQJ1
resolver
uniprot
Q4V9S4
resolver
uniprot
Q96JT6
resolver
uniprot
Q9UD20
resolver
uniprot_entry
S39A2_HUMAN
resolver
uniprot_sec
B2RC76
resolver
uniprot_sec
G3V5X2
resolver
uniprot_sec
Q4QQJ1
resolver
uniprot_sec
Q4V9S4
resolver
uniprot_sec
Q96JT6
resolver
uniprot_sec
Q9UD20
resolver
activity_regulation
ACTIVITY REGULATION: Activity is increased at acidic pH (6.5) (PubMed:29791142). Inhibited in the presence of high extracellular K(+) (PubMed:29791142, PubMed:30914478). {ECO:0000269|PubMed:29791142, ECO:0000269|PubMed:30914478}.
uniprot
proteins
amino_acid_sequence
MEQLLGIKLGCLFALLALTLGCGLTPICFKWFQIDAARGHHRLVLRLLGCISAGVFLGAGFMHMTAEALEEIESQIQKFMVQNRSASERNSSGDADSAHMEYPYGELIISLGFFFVFFLESLALQCCPGAAGGSTVQDEEWGGAHIFELHSHGHLPSPSKGPLRALVLLLSLSFHSVFEGLAVGLQPTVAATVQLCLAVLAHKGLVVFGVGMRLVHLGTSSRWAVFSILLLALMSPLGLAVGLAVTGGDSEGGRGLAQAVLEGVAAGTFLYVTFLEILPRELASPEAPLAKWSCVAAGFAFMAFIALWA
uniprot
proteins
function
FUNCTION: Transporter for the divalent cation Zn(2+) (PubMed:10681536, PubMed:29791142, PubMed:30914478). Mediates the influx of Zn(2+) into cells from extracellular space. The Zn(2+) uniporter activity is independent of H(+)-driving force, but is modulated by extracellular pH and membrane potential. Also transports other divalent cations Zn(2+), Cd2(+), Cu2(+), Co2(+) in the order of decreasing affinity, respectively (PubMed:29791142, PubMed:30914478). In the skin, aids in the differentiation of keratinocytes in the epidermis (By similarity). {ECO:0000250|UniProtKB:G3X943, ECO:0000269|PubMed:10681536, ECO:0000269|PubMed:29791142, ECO:0000269|PubMed:30914478}.
uniprot
proteins
mass_dalton
32742
uniprot
proteins
mutagenesis
MUTAGEN 63; /note="H->A: Decreased of about 60% in transport activity. Loss of pH dependence for transport activity."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 67; /note="E->A: Decreased of about 35% in transport activity. Alters the pH and voltage modulation of the transporter."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 70; /note="E->A: Increased of about 65% in transport activity. Does not change H(+) affinity."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 71; /note="E->A,Q: Does not affect pH sensitivity."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 106; /note="E->A: Decreased of about 30% in transport activity."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 106; /note="E->Q: Increased of about 35% in transport activity."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 120; /note="E->A: Does not affect pH sensitivity."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 175; /note="H->A: Abolishes transport activity."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 176; /note="S->A: Does not alter the substrate selectivity of SLC39A2."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 179; /note="E->A: Decreased of about 60% in transport activity. Does not alter the substrate selectivity of SLC39A2."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 179; /note="E->Q: Abolishes transport activity."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 202; /note="H->A: Abolishes transport activity."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 202; /note="H->E: Does not affect transport kinetics parameters. Exhibits a broader substrate selectivity."; MUTAGEN 203; /note="K->A: Decreased of about 78% in transport activity."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 203; /note="K->Q: Abolishes transport activity."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 203; /note="K->R: Decreases of about 72% in transport activity."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 269; /note="F->A: Exhibits a broader substrate selectivity."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 269; /note="F->L: Exhibits a broader substrate selectivity."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 276; /note="E->A: Abolishes transport activity."; /evidence="ECO:0000269|PubMed:30914478"; MUTAGEN 276; /note="E->Q: Does not affect transport activity. Reduces affinity for H(+)."; /evidence="ECO:0000269|PubMed:30914478
uniprot
proteins
protein_family
ZIP transporter (TC 2.A.5) family
uniprot
proteins
pubmed
10681536
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
29791142
uniprot
proteins
pubmed
30914478
uniprot
proteins
pubmed
7751801
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10681536, ECO:0000269|PubMed:30914478}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 259..279; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins