Ncbp3
entrez
66874
canonical
uniprot
Q8BZR9
canonical
ensembl
ENSMUSG00000020783
resolver
ensp
ENSMUSP00000021135
resolver
genesymbol
Ncbp3
resolver
uniprot
Q3TNF4
resolver
uniprot
Q3TQ96
resolver
uniprot
Q4G0C3
resolver
uniprot
Q8BMB1
resolver
uniprot
Q9CRM6
resolver
uniprot
Q9CS93
resolver
uniprot
Q9D0G9
resolver
uniprot
Q9DBT0
resolver
uniprot_entry
NCBP3_MOUSE
resolver
uniprot_sec
Q3TNF4
resolver
uniprot_sec
Q3TQ96
resolver
uniprot_sec
Q4G0C3
resolver
uniprot_sec
Q8BMB1
resolver
uniprot_sec
Q9CRM6
resolver
uniprot_sec
Q9CS93
resolver
uniprot_sec
Q9D0G9
resolver
uniprot_sec
Q9DBT0
resolver
amino_acid_sequence
MAAVRGLRVSVKAEAPAGPALGLPSPEVESGLERGEPEPMEVEEGELEIVPVRRSLKELLPDTSRRYENKAGSFITGIDVTSKEAIEKKEQRAKRFHFRAEVNLAQRNVALDRDMMKKAIPKVRLETIYICGVDEMSTQDIFSYFKEYPPAHIEWLDDTSCNVVWLDEMTATRALINMSSLPAQDKMRSRDASEDKSSEKNKKDKQEDSSDDDETEEGEVEDENSSDVELDTLSQVEEESLLRNDLRPANKLAKGNRLFMRFATKDDKKELGAARRSQYYMKYGNPNYGGMKGILSNSWKRRYHSRRIQRDVIKKRALIGDDVGLTSYKHRHSGLVNVPEEPIEEEEEEEEEEEDQDMDADDRVVVEYHEELPGLKQPRERSLSRRSSASSSDSDEMDYDLELKMISTPSPKKSMKMTMYADEVESQLKSIRNPMRADSISTSNIKNRIGNKLPPEKFADVRHLLDEKRQHSCPRPAVSSTKPDIRQRLGKRPYSPEKAFSSNQVVRREPSSDVHSRLGVPRQDVKGLYSDTRERKSGGLWTRLGSTPKTKEKNTKKVDHRASGAEEDDSELQRAWGALIKEKEESRQKKSRLDSLPSLQIEVSRESSSGSEAES
uniprot
proteins
function
FUNCTION: Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858). {ECO:0000269|PubMed:26382858}.
uniprot
proteins
mass_dalton
70043
uniprot
proteins
protein_family
NCBP3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26382858
uniprot
proteins
sequence_length
615
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q53F19}. Cytoplasm {ECO:0000250|UniProtKB:Q53F19}.
uniprot
proteins