Slc20a2
entrez
29502
canonical
uniprot
Q63488
canonical
ensembl
ENSRNOG00000019490
resolver
ensembl
ENSRNOG00055007711
resolver
ensembl
ENSRNOG00060028072
resolver
ensembl
ENSRNOG00065008781
resolver
ensp
ENSRNOP00000026418
resolver
ensp
ENSRNOP00055010323
resolver
ensp
ENSRNOP00060040750
resolver
ensp
ENSRNOP00065010447
resolver
enst
ENSRNOT00000026418
resolver
enst
ENSRNOT00055012939
resolver
enst
ENSRNOT00060048842
resolver
enst
ENSRNOT00065014003
resolver
genesymbol
Slc20a2
resolver
genesymbol_syn
Pit2
resolver
genesymbol_syn
Ram1
resolver
uniprot_entry
S20A2_RAT
resolver
amino_acid_sequence
MAMDGYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGPKGVQWMELVKIVASWFISPLLSGFMSGVLFILIRMFILTKEDPVPNGLQALPLFYAATIAINVFSIMYTGAPVLGLSLPIWAIALISFGVALLFAFFVWLFVCPWMKRKIAGRLEKESALSRASDESLRKVQEAESPVFKELPGAKASDDSAVPLTSLAGEAAGASEGTSAGNHPRASYGRALSMTHGSAKSPISNGTFGFEGHMRNDGHVYHTVHKDSGLYKDLLHKIHVDKGPEEKPAQENNYRLLRRNNSYTCYTAAICGMPVHATFRASDTSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMRLASELTDPDQPHEDPAEDEKEEKDSAEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFIAWFVTVPVAGLFSAAIMALLMYICGFVSSSR
uniprot
proteins
function
FUNCTION: Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:19073637, PubMed:8041748). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q08357, ECO:0000269|PubMed:19073637, ECO:0000269|PubMed:8041748}.
uniprot
proteins
mass_dalton
70748
uniprot
proteins
protein_family
Inorganic phosphate transporter (PiT) (TC 2.A.20) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19073637
uniprot
proteins
pubmed
20526720
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8041748
uniprot
proteins
pubmed
8278411
uniprot
proteins
sequence_length
656
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20526720}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:19073637}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of the proximal tubules (PubMed:19073637, PubMed:20526720). Parathyroid hormone decreases its abundance in brush border membrane (PubMed:20526720). {ECO:0000269|PubMed:19073637, ECO:0000269|PubMed:20526720}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 191..211; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 484..504; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 532..552; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 573..586; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 595..610; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 623..643; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins