LPIN2
entrez
9663
canonical
uniprot
Q92539
canonical
ensembl
ENSG00000101577
resolver
ensp
ENSP00000261596
resolver
ensp
ENSP00000504857
resolver
ensp
ENSP00000513062
resolver
ensp
ENSP00000568025
resolver
ensp
ENSP00000568026
resolver
ensp
ENSP00000568027
resolver
ensp
ENSP00000568028
resolver
ensp
ENSP00000582822
resolver
ensp
ENSP00000582823
resolver
ensp
ENSP00000582824
resolver
enst
ENST00000261596
resolver
enst
ENST00000677752
resolver
enst
ENST00000697040
resolver
enst
ENST00000897964
resolver
enst
ENST00000897967
resolver
enst
ENST00000897968
resolver
enst
ENST00000897969
resolver
enst
ENST00000912763
resolver
enst
ENST00000912764
resolver
enst
ENST00000912765
resolver
genesymbol
LPIN2
resolver
genesymbol_syn
KIAA0249
resolver
hgnc
HGNC:14450
resolver
uniprot
A7MD25
resolver
uniprot
D3DUH3
resolver
uniprot_entry
LPIN2_HUMAN
resolver
uniprot_sec
A7MD25
resolver
uniprot_sec
D3DUH3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethylmaleimide. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MNYVGQLAGQVIVTVKELYKGINQATLSGCIDVIVVQQQDGSYQCSPFHVRFGKLGVLRSKEKVIDIEINGSAVDLHMKLGDNGEAFFVEETEEEYEKLPAYLATSPIPTEDQFFKDIDTPLVKSGGDETPSQSSDISHVLETETIFTPSSVKKKKRRRKKYKQDSKKEEQAASAAAEDTCDVGVSSDDDKGAQAARGSSNASLKEEECKEPLLFHSGDHYPLSDGDWSPLETTYPQTACPKSDSELEVKPAESLLRSESHMEWTWGGFPESTKVSKRERSDHHPRTATITPSENTHFRVIPSEDNLISEVEKDASMEDTVCTIVKPKPRALGTQMSDPTSVAELLEPPLESTQISSMLDADHLPNAALAEAPSESKPAAKVDSPSKKKGVHKRSQHQGPDDIYLDDLKGLEPEVAALYFPKSESEPGSRQWPESDTLSGSQSPQSVGSAAADSGTECLSDSAMDLPDVTLSLCGGLSENGEISKEKFMEHIITYHEFAENPGLIDNPNLVIRIYNRYYNWALAAPMILSLQVFQKSLPKATVESWVKDKMPKKSGRWWFWRKRESMTKQLPESKEGKSEAPPASDLPSSSKEPAGARPAENDSSSDEGSQELEESITVDPIPTEPLSHGSTTSYKKSLRLSSDQIAKLKLHDGPNDVVFSITTQYQGTCRCAGTIYLWNWNDKIIISDIDGTITKSDALGQILPQLGKDWTHQGIAKLYHSINENGYKFLYCSARAIGMADMTRGYLHWVNDKGTILPRGPLMLSPSSLFSAFHREVIEKKPEKFKIECLNDIKNLFAPSKQPFYAAFGNRPNDVYAYTQVGVPDCRIFTVNPKGELIQERTKGNKSSYHRLSELVEHVFPLLSKEQNSAFPCPEFSSFCYWRDPIPEVDLDDLS
uniprot
proteins
disease_involvement
DISEASE: Majeed syndrome (MJDS) [MIM:609628]: An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration). {ECO:0000269|PubMed:15994876}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.3.4
uniprot
proteins
function
FUNCTION: Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}.
uniprot
proteins
mass_dalton
99399
uniprot
proteins
protein_family
Lipin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15994876
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17158099
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9039502
uniprot
proteins
sequence_length
896
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Note=Translocates to endoplasmic reticulum membrane with increasing levels of oleate. {ECO:0000250}.
uniprot
proteins