Dcc
entrez
25311
canonical
uniprot
Q63155
canonical
ensembl
ENSRNOG00000033099
resolver
ensp
ENSRNOP00000063072
resolver
ensp
ENSRNOP00000096451
resolver
ensp
ENSRNOP00000101128
resolver
ensp
ENSRNOP00000102890
resolver
enst
ENSRNOT00000101171
resolver
enst
ENSRNOT00000124479
resolver
enst
ENSRNOT00000150851
resolver
genesymbol
Dcc
resolver
uniprot
A0A8I6ATC8
resolver
uniprot
A0ABK0KZX1
resolver
uniprot
A0ABK0L2C4
resolver
uniprot_entry
A0A8I6ATC8_RAT
resolver
uniprot_entry
A0ABK0KZX1_RAT
resolver
uniprot_entry
A0ABK0L2C4_RAT
resolver
uniprot_entry
DCC_RAT
resolver
amino_acid_sequence
MENSLGCVWVPKLAFVLFGASLLSAHLQVTGFQIKPFTSLHFVSEPSDAVTMRGGNVLLNCSAESDRGVPVIKWKKDGLILALGMDDRKQQLPNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVMVAGPLRFLSQTESITAFMGDTVLLKCEVIGDPMPTIHWQKNQQDLNPIPGDSRVVVLPSGALQISRLQPGDSGVYRCSARNPASTRTGNEAEVRILSDPGLHRQLYFLQRPSNVIAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQSSAQLIVPKPAIPSSSILPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLHAVSASPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPMLPPVGVQAVALTHEAVRVSWADNSVPKNQKTSDVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQARNAKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVITVVTVGVLTVLVVVIVAVICTRRSSAQQRKKRATHSASKRKGSQKDLRPPDLWIHHEEMEMKNIEKPAGTDPAGRGSPIQSCQDLTPVSHSQSESQMGSKSASHSGQDTEEAGSSMSTLERSLAARRATRTKLMIPMEAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRTVSEGPTAQQQPMLPPAQPEHPSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDPASVYEQDDLSEQMASLEGLMKQLNAITGSAF
uniprot
proteins
function
FUNCTION: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene (By similarity). {ECO:0000250, ECO:0000269|PubMed:8861902}.
uniprot
proteins
mass_dalton
157941
uniprot
proteins
mutagenesis
MUTAGEN 1178; /note="S->A: Abolishes phosphorylation by MAPK1; when associated with A-1187 and A-1267."; /evidence="ECO:0000269|PubMed:21070949"; MUTAGEN 1187; /note="T->A: Abolishes phosphorylation by MAPK1; when associated with A-1178 and A-1267."; /evidence="ECO:0000269|PubMed:21070949"; MUTAGEN 1267; /note="S->A: Abolishes phosphorylation by MAPK1; when associated with A-1178 and A-1187."; /evidence="ECO:0000269|PubMed:21070949
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. {ECO:0000250|UniProtKB:P43146}.
uniprot
proteins
protein_family
DCC family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
10399920
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
21070949
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
37669666
uniprot
proteins
pubmed
8861902
uniprot
proteins
sequence_length
1445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:8861902}; Single-pass type I membrane protein {ECO:0000269|PubMed:8861902}.
uniprot
proteins
transmembrane_region
TRANSMEM 1100..1120; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins