MS4A2
entrez
2206
canonical
uniprot
Q01362
canonical
ensembl
ENSG00000149534
resolver
ensp
ENSP00000278888
resolver
ensp
ENSP00000482594
resolver
enst
ENST00000278888
resolver
enst
ENST00000617306
resolver
genesymbol
MS4A2
resolver
genesymbol_syn
APY
resolver
genesymbol_syn
FCER1B
resolver
genesymbol_syn
IGER
resolver
hgnc
HGNC:7316
resolver
uniprot
A0A0B4J2E9
resolver
uniprot
Q54A81
resolver
uniprot_entry
A0A0B4J2E9_HUMAN
resolver
uniprot_entry
FCERB_HUMAN
resolver
uniprot_sec
Q54A81
resolver
amino_acid_sequence
MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTEIVVMMLFLTILGLGSAVSLTICGAGEELKGNKVPEDRVYEELNIYSATYSELEDPGEMSPPIDL
uniprot
proteins
function
FUNCTION: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.
uniprot
proteins
mass_dalton
26534
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by LYN. {ECO:0000250}.
uniprot
proteins
protein_family
MS4A family
uniprot
proteins
pubmed
12697656
uniprot
proteins
pubmed
1386024
uniprot
proteins
pubmed
1535625
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8817330
uniprot
proteins
pubmed
8842731
uniprot
proteins
pubmed
8968765
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 60..79; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 98..117; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 131..150; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 181..200; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins