RNGTT
entrez
8732
canonical
uniprot
O60942
canonical
ensembl
ENSG00000111880
resolver
ensp
ENSP00000358487
resolver
ensp
ENSP00000358497
resolver
ensp
ENSP00000718464
resolver
genesymbol
RNGTT
resolver
genesymbol_syn
CAP1A
resolver
hgnc
HGNC:10073
resolver
uniprot
B4DSJ8
resolver
uniprot
E1P513
resolver
uniprot
E1P514
resolver
uniprot
O43483
resolver
uniprot
O60257
resolver
uniprot
O60351
resolver
uniprot
Q5TCW8
resolver
uniprot
Q8WUM8
resolver
uniprot_entry
B4DSJ8_HUMAN
resolver
uniprot_entry
MCE1_HUMAN
resolver
uniprot_sec
E1P513
resolver
uniprot_sec
E1P514
resolver
uniprot_sec
O43483
resolver
uniprot_sec
O60257
resolver
uniprot_sec
O60351
resolver
uniprot_sec
Q5TCW8
resolver
uniprot_sec
Q8WUM8
resolver
amino_acid_sequence
MAHNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGDYLKELFRRYGDIEEAPPPPLLPDWCFEDDEDEDEDEDGKKESEPGSSASFGKRRKERLKLGAIFLEGVTVKGVTQVTTQPKLGEVQQKCHQFCGWEGSGFPGAQPVSMDKQNIKLLDLKPYKVSWKADGTRYMMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLRMHLSNTLLDGEMIIDRVNGQAVPRYLIYDIIKFNSQPVGDCDFNVRLQCIEREIISPRHEKMKTGLIDKTQEPFSVRNKPFFDICTSRKLLEGNFAKEVSHEMDGLIFQPTGKYKPGRCDDILKWKPPSLNSVDFRLKITRMGGEGLLPQNVGLLYVGGYERPFAQIKVTKELKQYDNKIIECKFENNSWVFMRQRTDKSFPNAYNTAMAVCNSISNPVTKEMLFEFIDRCTAASQGQKRKHHLDPDTELMPPPPPKRPRPLT
uniprot
proteins
ec_number
2.7.7.50
uniprot
proteins
ec_number
3.6.1.74
uniprot
proteins
function
FUNCTION: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate. {ECO:0000269|PubMed:21636784, ECO:0000269|PubMed:9473487, ECO:0000269|PubMed:9512541}.
uniprot
proteins
mass_dalton
68557
uniprot
proteins
mutagenesis
MUTAGEN 234; /note="E->A: No effect on GTase activity."; /evidence="ECO:0000269|PubMed:21636784"; MUTAGEN 294; /note="K->A: Loss of GTase activity."; /evidence="ECO:0000269|PubMed:9512541"; MUTAGEN 299; /note="R->A: Loss of GTase activity."; /evidence="ECO:0000269|PubMed:9512541"; MUTAGEN 345; /note="E->A: Loss of GTase activity."; /evidence="ECO:0000269|PubMed:9512541"; MUTAGEN 458; /note="K->A: Loss of GTase activity."; /evidence="ECO:0000269|PubMed:21636784, ECO:0000269|PubMed:9512541"; MUTAGEN 460; /note="K->A: Loss of GTase activity."; /evidence="ECO:0000269|PubMed:21636784, ECO:0000269|PubMed:9512541"; MUTAGEN 528; /note="R->A: Strongly reduced GTase activity."; /evidence="ECO:0000269|PubMed:21636784"; MUTAGEN 530; /note="R->A: Loss of GTase activity."; /evidence="ECO:0000269|PubMed:21636784"; MUTAGEN 532; /note="D->A: Loss of GTase activity."; /evidence="ECO:0000269|PubMed:21636784"; MUTAGEN 533; /note="K->A: Loss of GTase activity."; /evidence="ECO:0000269|PubMed:21636784
uniprot
proteins
protein_family
Non-receptor class of the protein-tyrosine phosphatase family; Eukaryotic GTase family
uniprot
proteins
pubmed
10421630
uniprot
proteins
pubmed
11278368
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21636784
uniprot
proteins
pubmed
9371772
uniprot
proteins
pubmed
9473487
uniprot
proteins
pubmed
9512541
uniprot
proteins
pubmed
9705270
uniprot
proteins
sequence_length
597
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins