PLAAT2
entrez
54979
canonical
uniprot
Q9NWW9
canonical
ensembl
ENSG00000133328
resolver
ensp
ENSP00000255695
resolver
enst
ENST00000255695
resolver
genesymbol
PLAAT2
resolver
genesymbol_syn
HRASLS2
resolver
hgnc
HGNC:17824
resolver
uniprot
B9A7L8
resolver
uniprot_entry
PLAT2_HUMAN
resolver
uniprot_sec
B9A7L8
resolver
amino_acid_sequence
MALARPRPRLGDLIEISRFGYAHWAIYVGDGYVVHLAPASEIAGAGAASVLSALTNKAIVKKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHLRYGVSRSDQVTGAVTTVGVAAGLLAAASLVGILLARSKRERQ
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
3.1.1.32
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22605381, PubMed:22825852). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:22605381, PubMed:22825852). Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor (PubMed:22605381). Exhibits high phospholipase A1/2 activity and low N-acyltransferase activity (PubMed:22825852). {ECO:0000269|PubMed:19615464, ECO:0000269|PubMed:22605381, ECO:0000269|PubMed:22825852, ECO:0000303|PubMed:26503625}.
uniprot
proteins
mass_dalton
17394
uniprot
proteins
mutagenesis
MUTAGEN 113; /note="C->S: Loss of N-acyltransferase activity."; /evidence="ECO:0000269|PubMed:22825852
uniprot
proteins
protein_family
H-rev107 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
18163183
uniprot
proteins
pubmed
19615464
uniprot
proteins
pubmed
22605381
uniprot
proteins
pubmed
22825852
uniprot
proteins
pubmed
26503625
uniprot
proteins
sequence_length
162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18163183}. Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Note=Exhibits a granular pattern in the cytoplasm with preferential perinuclear localization. {ECO:0000269|PubMed:18163183}.
uniprot
proteins
transmembrane_region
TRANSMEM 134..154; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins