Pofut3
entrez
171167
canonical
uniprot
Q5F2L2
canonical
ensembl
ENSMUSG00000046152
resolver
ensp
ENSMUSP00000069816
resolver
ensp
ENSMUSP00000106156
resolver
ensp
ENSMUSP00000124437
resolver
ensp
ENSMUSP00000125265
resolver
ensp
ENSMUSP00000208682
resolver
ensp
ENSMUSP00000208683
resolver
genesymbol
Pofut3
resolver
genesymbol_syn
Fut10
resolver
uniprot
Q8C457
resolver
uniprot
Q8K0S3
resolver
uniprot
Q8R247
resolver
uniprot_entry
OFUT3_MOUSE
resolver
uniprot_sec
Q8C457
resolver
uniprot_sec
Q8K0S3
resolver
uniprot_sec
Q8R247
resolver
amino_acid_sequence
MVRFQRRKLLASCLCVTATVFLMVTLQVVVELGKFERKKLKDSNVQDGHRDVEGEPKHLEPFPEKEALALAGRTKVDAGSYPIVLWWSPLTGETGRLGQCGADACFFTINRTFQHHPMTRAFLFYGTDFNIDSLPLPREAHHDWALFHEESPKNNYKLFHKPVITLFNHTATFSRHSHLPLTTQYLEGVDVLKSLRYLVPLQAKNNLRQKLAPLVYVQSDCDPPSDRDSYVRELMAYIEVDSYGECLQNRDLPQQLKNPASMDADAFYRVIAQYKFILAFENAVCDDYITEKFWRPLKLGVVPVYYGSPTIADWLPSNRSAILVSEFSHPRELASFIRRLDYDDGLYETYVEWKLKGKISNQRLLTALNEREWGVQDINQDNYIDSFECMVCRRVWANSRLQEQGLPPKQWKADVSHLHCPEPALFTFSSPASPALRGRSLRELWLPSFQQSKKEAQALRWLVDRNQNFSSEEFWALVFKD
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.1.221
uniprot
proteins
function
FUNCTION: Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1 (By similarity). Attaches fucose through an O-glycosidic linkage (By similarity). O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion (By similarity). May also show alpha-(1,3)-fucosyltransferase activity toward the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors (By similarity). However, this was tested with a library of synthetic substrates and this activity is unsure in vivo (By similarity). May be involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (PubMed:23986452). {ECO:0000250|UniProtKB:Q6P4F1, ECO:0000269|PubMed:23986452}.
uniprot
proteins
mass_dalton
55707
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q6P4F1}.
uniprot
proteins
protein_family
Glycosyltransferase 10 family
uniprot
proteins
pubmed
12370785
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23986452
uniprot
proteins
sequence_length
481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6P4F1}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..31; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins