ILKAP
entrez
80895
canonical
uniprot
Q9H0C8
canonical
ensembl
ENSG00000132323
resolver
ensp
ENSP00000254654
resolver
enst
ENST00000254654
resolver
genesymbol
ILKAP
resolver
hgnc
HGNC:15566
resolver
uniprot
B3KM39
resolver
uniprot_entry
ILKAP_HUMAN
resolver
uniprot_sec
B3KM39
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited rather than stimulated by magnesium.
uniprot
proteins
amino_acid_sequence
MDLFGDLPEPERSPRPAAGKEAQKGPLLFDDLPPASSTDSGSGGPLLFDDLPPASSGDSGSLATSISQMVKTEGKGAKRKTSEEEKNGSEELVEKKVCKASSVIFGLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVVRIGH
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. {ECO:0000269|PubMed:14990992}.
uniprot
proteins
mass_dalton
42907
uniprot
proteins
mutagenesis
MUTAGEN 152; /note="D->A: Loss of >90% of activity."; /evidence="ECO:0000269|PubMed:11331582"; MUTAGEN 154; /note="H->D: Loss of >90% of activity."; /evidence="ECO:0000269|PubMed:11331582"; MUTAGEN 154; /note="H->L: Loss of >90% of activity."; /evidence="ECO:0000269|PubMed:11331582
uniprot
proteins
protein_family
PP2C family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11331582
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14990992
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11331582}.
uniprot
proteins