Hcls1
entrez
15163
canonical
uniprot
P49710
canonical
ensembl
ENSMUSG00000022831
resolver
ensp
ENSMUSP00000023531
resolver
enst
ENSMUST00000023531
resolver
genesymbol
Hcls1
resolver
genesymbol_syn
Hs1
resolver
uniprot
Q8CA06
resolver
uniprot
Q922I8
resolver
uniprot_entry
HCLS1_MOUSE
resolver
uniprot_entry
Q8CA06_MOUSE
resolver
uniprot_sec
Q922I8
resolver
amino_acid_sequence
MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNKVSEEHDILKKKELESGPKASHGYGGRFGVERDRMDKSAVGHEYVADVEKHSSQTDAARGFGGKYGVERDRADKSAVGFDYKGEVEKHASQKDYSHGFGGRYGVEKDKRDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKAKFESLAEEKRKREEEEKAQQMARQQQERKAVVKMSREVQQPSMPVEEPAAPAQLPKKISSEVWPPAESHLPPESQPVRSRREYPVPSLPTRQSPLQNHLEDNEEPPALPPRTPEGLQVVEEPVYEAAPELEPEPEPDYEPEPETEPDYEDVGELDRQDEDAEGDYEDVLEPEDTPSLSYQAGPSAGAGGAGISAIALYDYQGEGSDELSFDPDDIITDIEMVDEGWWRGQCRGHFGLFPANYVKLL
uniprot
proteins
function
FUNCTION: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
54240
uniprot
proteins
mutagenesis
MUTAGEN 388; /note="Y->F: Strongly reduces phosphorylation by FES. Abolishes phosphorylation by FES; when associated with F-405."; /evidence="ECO:0000269|PubMed:19001085"; MUTAGEN 405; /note="Y->F: Minor effect on phosphorylation by FES. Abolishes phosphorylation by FES; when associated with F-388."; /evidence="ECO:0000269|PubMed:19001085
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK (By similarity). Binds to LCK in vivo, and is tyrosine phosphorylated upon TCR stimulation. Phosphorylated by FES. {ECO:0000250, ECO:0000269|PubMed:19001085}.
uniprot
proteins
pubmed
10590261
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19001085
uniprot
proteins
pubmed
19064729
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7535527
uniprot
proteins
pubmed
7628441
uniprot
proteins
pubmed
8943564
uniprot
proteins
sequence_length
486
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
uniprot
proteins