Hgs
entrez
56084
canonical
uniprot
Q9JJ50
canonical
ensembl
ENSRNOG00000036696
resolver
ensp
ENSRNOP00000103548
resolver
ensp
ENSRNOP00000108384
resolver
genesymbol
Hgs
resolver
genesymbol_syn
Hrs
resolver
genesymbol_syn
Hrs2
resolver
uniprot
P97847
resolver
uniprot
Q5XIV8
resolver
uniprot
Q76N76
resolver
uniprot_entry
HGS_RAT
resolver
uniprot_sec
P97847
resolver
uniprot_sec
Q5XIV8
resolver
uniprot_sec
Q76N76
resolver
amino_acid_sequence
MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKELLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNKKAEGKAASTTELPPEYLTSPLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERMRQKSTYTAHPKSEPAPLASSAPPAGSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQPGEGHTAPNSMVEAPLPETDSQPITSCSGPFSEQYQNGESEESHEQFLKALQNAVSTFVNRMKSNHMRGRSITNDSAVLSLFQSINSTHPQLLELLNRLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPTAGGVLYQPSGPTSFPGTFSPAGSVEGSPMHGVYMSQPAPATGPYPSMPGTTADPSMVSAYMYPAGAPGAQAAPQAQAGPTTNPAYSSYQPTPTPGYQNVASQAPQSLPAISQPPQTSNIGYMGSQPMSMGYQPYNMQNLMTTLPGQDASLPAQQPYITGQQPMYQQMAPSTGPPQQQPPVAQPPPTQGPPAQGNETQLISFD
uniprot
proteins
function
FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). May contribute to the efficient recruitment of SMADs to the activin receptor complex. {ECO:0000250}.
uniprot
proteins
mass_dalton
86246
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr-334. This phosphorylation occurs in response to EGF. A minor site of phosphorylation on Tyr-329 is detected. Protein phosphorylation may also be triggered in response to IL-2, GM-CSF and HGF (By similarity). {ECO:0000250|UniProtKB:Q99LI8}.; PTM: Ubiquitinated by ITCH. {ECO:0000250|UniProtKB:O14964}.
uniprot
proteins
pubmed
10809762
uniprot
proteins
pubmed
10825299
uniprot
proteins
pubmed
11110793
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17062640
uniprot
proteins
pubmed
9039916
uniprot
proteins
pubmed
9798906
uniprot
proteins
sequence_length
776
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10825299}. Early endosome membrane {ECO:0000269|PubMed:10825299}; Peripheral membrane protein {ECO:0000269|PubMed:10825299}; Cytoplasmic side {ECO:0000269|PubMed:10825299}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:10825299}; Peripheral membrane protein {ECO:0000269|PubMed:10825299}. Note=Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments. {ECO:0000250|UniProtKB:O14964}.
uniprot
proteins