SETD4
entrez
54093
canonical
uniprot
Q9NVD3
canonical
ensembl
ENSG00000185917
resolver
ensp
ENSP00000329189
resolver
ensp
ENSP00000382152
resolver
ensp
ENSP00000382156
resolver
ensp
ENSP00000382159
resolver
ensp
ENSP00000382161
resolver
ensp
ENSP00000396837
resolver
ensp
ENSP00000399998
resolver
ensp
ENSP00000572572
resolver
ensp
ENSP00000572573
resolver
ensp
ENSP00000572576
resolver
ensp
ENSP00000601925
resolver
ensp
ENSP00000601928
resolver
ensp
ENSP00000743868
resolver
ensp
ENSP00000743869
resolver
ensp
ENSP00000786169
resolver
ensp
ENSP00000786171
resolver
ensp
ENSP00000786177
resolver
enst
ENST00000399201
resolver
enst
ENST00000399205
resolver
genesymbol
SETD4
resolver
genesymbol_syn
C21orf18
resolver
genesymbol_syn
C21orf27
resolver
hgnc
HGNC:1258
resolver
uniprot
A8MTS1
resolver
uniprot
B4DT14
resolver
uniprot
D3DSG2
resolver
uniprot
D3DSG4
resolver
uniprot
Q8NE19
resolver
uniprot
Q9BU46
resolver
uniprot_entry
A8MTS1_HUMAN
resolver
uniprot_entry
SETD4_HUMAN
resolver
uniprot_sec
B4DT14
resolver
uniprot_sec
D3DSG2
resolver
uniprot_sec
D3DSG4
resolver
uniprot_sec
Q8NE19
resolver
uniprot_sec
Q9BU46
resolver
amino_acid_sequence
MQKGKGRTSRIRRRKLCGSSESRGVNESHKSEFIELRKWLKARKFQDSNLAPACFPGTGRGLMSQTSLQEGQMIISLPESCLLTTDTVIRSYLGAYITKWKPPPSPLLALCTFLVSEKHAGHRSLWKPYLEILPKAYTCPVCLEPEVVNLLPKSLKAKAEEQRAHVQEFFASSRDFFSSLQPLFAEAVDSIFSYSALLWAWCTVNTRAVYLRPRQRECLSAEPDTCALAPYLDLLNHSPHVQVKAAFNEETHSYEIRTTSRWRKHEEVFICYGPHDNQRLFLEYGFVSVHNPHACVYVSREILVKYLPSTDKQMDKKISILKDHGYIENLTFGWDGPSWRLLTALKLLCLEAEKFTCWKKVLLGEVISDTNEKTSLDIAQKICYYFIEETNAVLQKVSHMKDEKEALINQLTLVESLWTEELKILRASAETLHSLQTAFT
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.364
uniprot
proteins
function
FUNCTION: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins (PubMed:31308046, PubMed:35545041, PubMed:37926288). Via its catalytic activity, regulates many processes, including cell proliferation, cell differentiation, inflammatory response and apoptosis. Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of pro-inflammatory cytokines IL6 and TNF (By similarity). Through the catalysis of TBK1 monomethylation, may regulate virus-induced interferon signaling. TBK1 monomethylation enhances its interaction with MAVS, STING and IRF3, hence promoting antiviral interferon signaling (PubMed:37926288). Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (PubMed:31308046). In the brain, epigenetically controls quiescence of neural stem cells for sustaining a protected neural stem cell population and maintaining a stem cell reservoir for neurogenesis (By similarity). Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (By similarity). Through the catalysis of XRCC5/Ku70 trimethylation, regulates BAX-mediated apoptosis. SETD4-catalyzed XRCC5 methylation results in XRCC5 translocation to the cytoplasm, where it interacts with BAX, sequestering it from the mitochondria, hence preventing BAX-mediated apoptosis (PubMed:35545041). {ECO:0000250|UniProtKB:P58467, ECO:0000269|PubMed:31308046, ECO:0000269|PubMed:35545041, ECO:0000269|PubMed:37926288}.
uniprot
proteins
mass_dalton
50416
uniprot
proteins
mutagenesis
MUTAGEN 61; /note="G->V: Abolished histone-lysine N-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31308046"; MUTAGEN 233; /note="D->A: Abolished histone-lysine N-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31308046"; MUTAGEN 236..237; /note="NH->AA: Loss of the ability to promote Sendai virus-induced IFNB1 promoter activation."; /evidence="ECO:0000269|PubMed:37926288"; MUTAGEN 272; /note="Y->F: Loss of N-methyltransferase activity toward XRCC6; when associated F-284."; /evidence="ECO:0000269|PubMed:35545041"; MUTAGEN 284; /note="Y->F: Loss of N-methyltransferase activity toward XRCC6; when associated F-272."; /evidence="ECO:0000269|PubMed:35545041
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
SETD4 family
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
11707072
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
24738023
uniprot
proteins
pubmed
31308046
uniprot
proteins
pubmed
35545041
uniprot
proteins
pubmed
37926288
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24738023, ECO:0000269|PubMed:37926288}. Nucleus {ECO:0000269|PubMed:24738023}.
uniprot
proteins