ABHD8
entrez
79575
canonical
uniprot
Q96I13
canonical
ensembl
ENSG00000127220
resolver
ensp
ENSP00000247706
resolver
ensp
ENSP00000621503
resolver
enst
ENST00000247706
resolver
enst
ENST00000951444
resolver
genesymbol
ABHD8
resolver
hgnc
HGNC:23759
resolver
uniprot
B2C6G3
resolver
uniprot
Q9HAE9
resolver
uniprot_entry
ABHD8_HUMAN
resolver
uniprot_entry
B2C6G3_HUMAN
resolver
uniprot_sec
Q9HAE9
resolver
amino_acid_sequence
MLTGVTDGIFCCLLGTPPNAVGPLESVESSDGYTFVEVKPGRVLRVKHAGPAPAAAPPPPSSASSDAAQGDLSGLVRCQRRITVYRNGRLLVENLGRAPRADLLHGQNGSGEPPAALEVELADPAGSDGRLAPGSAGSGSGSGSGGRRRRARRPKRTIHIDCEKRITSCKGAQADVVLFFIHGVGGSLAIWKEQLDFFVRLGYEVVAPDLAGHGASSAPQVAAAYTFYALAEDMRAIFKRYAKKRNVLIGHSYGVSFCTFLAHEYPDLVHKVIMINGGGPTALEPSFCSIFNMPTCVLHCLSPCLAWSFLKAGFARQGAKEKQLLKEGNAFNVSSFVLRAMMSGQYWPEGDEVYHAELTVPVLLVHGMHDKFVPVEEDQRMAEILLLAFLKLIDEGSHMVMLECPETVNTLLHEFLLWEPEPSPKALPEPLPAPPEDKK
uniprot
proteins
ec_number
3.-.-.-
uniprot
proteins
function
FUNCTION: Negatively regulates NLRP3-driven inflammation (PubMed:39225180). Promotes NLRP3 degradation through the chaperone-mediated autophagy (CMA) pathway, hence attenuating inflammasome activation and IL1B secretion. Acts by recruiting palmitoyltransferase ZDHHC12 to NLRP3, facilitating NLRP3 palmitoylation and subsequent degradation (PubMed:39225180). {ECO:0000269|PubMed:39225180}.
uniprot
proteins
mass_dalton
47331
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
39225180
uniprot
proteins
sequence_length
439
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:39225180}.
uniprot
proteins