Slc16a10
entrez
72472
canonical
uniprot
Q3U9N9
canonical
ensembl
ENSMUSG00000019838
resolver
ensp
ENSMUSP00000090227
resolver
ensp
ENSMUSP00000150416
resolver
genesymbol
Slc16a10
resolver
genesymbol_syn
Mct10
resolver
genesymbol_syn
Tat1
resolver
uniprot
Q3TNJ1
resolver
uniprot
Q3UAN9
resolver
uniprot
Q8BWR7
resolver
uniprot_entry
MOT10_MOUSE
resolver
uniprot_sec
Q3TNJ1
resolver
uniprot_sec
Q3UAN9
resolver
uniprot_sec
Q8BWR7
resolver
amino_acid_sequence
MVPSQEEPAAERETNEAQPPGPAPSDDAPLPGPGPSDVSDVAAEKVEVELTRSAGSEPPVPPEGGWGWLVMLAAMWCNGSVFGIQNAYGVLFVSMLDTFKAKDDDNMAFKTAWVGSLSMGMIFFCCPIVSVFTDMFGCRRTAVVGAAVGFIGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLGNLISSVKLFNTLRILCIFMFVLFLAGFTYRPLVPSTKEKESGGSRSSFFSRRKLSPPKKVFNFALFKETTYAVWAAGIPLALFGYFVPYVHLMNHVKERFQDVNNKEVLFMCIGITSGVGRLLFGRIADYLPGVKKVYLQVLSFFFIGLMSMMIPLCSAFGALIAVCLAMGLFDGCFISIMAPIAFELVGPQDASQAIGFLLGFMSIPMTVGPPIAGLLHDKLGTYDVAFYLAGIPPFVGGVVLCLIPWIHSKKQRKISKNAGGEKMEKMLENQSSLLSGSSGIFKKDSASII
uniprot
proteins
function
FUNCTION: Sodium- and proton-independent thyroid hormones and aromatic acids transporter. Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (By similarity). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:16245314). Plays an important role in homeostasis of aromatic amino acids (PubMed:23045339). {ECO:0000250|UniProtKB:Q8TF71, ECO:0000269|PubMed:16245314, ECO:0000269|PubMed:23045339}.
uniprot
proteins
mass_dalton
55320
uniprot
proteins
post_translational_modification
PTM: Not N-glycosylated.
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16245314
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23045339
uniprot
proteins
pubmed
24994998
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16245314}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:16245314}; Multi-pass membrane protein {ECO:0000255}. Note=Detected in basolateral membrane of kidney proximal tubule starting at he beginning of the proximal tubule epithelium within the glomerular capsule and extending to the S1 and S2 segments. Also localizes to the basolateral membrane of small intestine enterocytes and to sinusoidal side of perivenous hepatocytes. {ECO:0000269|PubMed:16245314}.
uniprot
proteins
transmembrane_region
TRANSMEM 64..84; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 169..189; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 292..312; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 327..347; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 363..383; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 385..405; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 417..437; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 449..469; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins