LANCL1
entrez
10314
canonical
uniprot
O43813
canonical
ensembl
ENSG00000115365
resolver
ensp
ENSP00000233714
resolver
ensp
ENSP00000388713
resolver
ensp
ENSP00000393323
resolver
ensp
ENSP00000393597
resolver
ensp
ENSP00000396518
resolver
ensp
ENSP00000397646
resolver
ensp
ENSP00000585378
resolver
ensp
ENSP00000631961
resolver
ensp
ENSP00000631962
resolver
ensp
ENSP00000631963
resolver
enst
ENST00000233714
resolver
enst
ENST00000431941
resolver
enst
ENST00000441020
resolver
enst
ENST00000443314
resolver
enst
ENST00000448951
resolver
enst
ENST00000450366
resolver
enst
ENST00000915319
resolver
enst
ENST00000961903
resolver
enst
ENST00000961904
resolver
genesymbol
LANCL1
resolver
genesymbol_syn
GPR69A
resolver
hgnc
HGNC:6508
resolver
uniprot
B2R602
resolver
uniprot_entry
B2R602_HUMAN
resolver
uniprot_entry
LANC1_HUMAN
resolver
amino_acid_sequence
MAQRAFPNPYADYNKSLAEGYFDAAGRLTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVAAVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMYEWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEKYLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLLVPTKARFPAFEL
uniprot
proteins
ec_number
2.5.1.18
uniprot
proteins
function
FUNCTION: Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316). {ECO:0000250|UniProtKB:O89112, ECO:0000269|PubMed:19528316}.
uniprot
proteins
mass_dalton
45283
uniprot
proteins
mutagenesis
MUTAGEN 4; /note="R->A: Loss of glutathione binding."; /evidence="ECO:0000269|PubMed:19528316"; MUTAGEN 317; /note="K->A: Loss of glutathione binding."; /evidence="ECO:0000269|PubMed:19528316"; MUTAGEN 322; /note="C->A: Loss of glutathione binding."; /evidence="ECO:0000269|PubMed:19528316"; MUTAGEN 364; /note="R->A,E: Loss of glutathione binding."; /evidence="ECO:0000269|PubMed:19528316
uniprot
proteins
protein_family
LanC-like protein family
uniprot
proteins
pubmed
10944443
uniprot
proteins
pubmed
11474189
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15811525
uniprot
proteins
pubmed
16979580
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19528316
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
9512664
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15811525}. Cell membrane {ECO:0000269|PubMed:10944443, ECO:0000269|PubMed:16979580}; Peripheral membrane protein {ECO:0000269|PubMed:10944443}.
uniprot
proteins