MAP2K4
entrez
6416
canonical
uniprot
P45985
canonical
ensembl
ENSG00000065559
resolver
ensp
ENSP00000262445
resolver
ensp
ENSP00000410402
resolver
ensp
ENSP00000685001
resolver
genesymbol
MAP2K4
resolver
genesymbol_syn
JNKK1
resolver
genesymbol_syn
MEK4
resolver
genesymbol_syn
MKK4
resolver
genesymbol_syn
PRKMK4
resolver
genesymbol_syn
SEK1
resolver
genesymbol_syn
SERK1
resolver
genesymbol_syn
SKK1
resolver
hgnc
HGNC:6844
resolver
uniprot
B2R7N7
resolver
uniprot
B3KYB2
resolver
uniprot
D3DTS5
resolver
uniprot
Q5U0B8
resolver
uniprot
Q6FHX4
resolver
uniprot
Q6P9H2
resolver
uniprot
Q6PIE6
resolver
uniprot_entry
MP2K4_HUMAN
resolver
uniprot_sec
B2R7N7
resolver
uniprot_sec
B3KYB2
resolver
uniprot_sec
D3DTS5
resolver
uniprot_sec
Q5U0B8
resolver
uniprot_sec
Q6FHX4
resolver
uniprot_sec
Q6P9H2
resolver
uniprot_sec
Q6PIE6
resolver
activity_regulation
ACTIVITY REGULATION: Activated in response to a variety of cellular stresses, including UV and gamma-irradiation, heat shock, hyperosmolarity, T-cell receptor stimulation, peroxide and inflammatory cytokines. Also activated by developmental cues. MAP2K4/MKK4 is activated by the majority of MKKKs, such as MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K7/TAK1, MAP3K10/MLK2, MAP3K11/MLK3, MAP3K12/DLK and MAP3K13/LZK. {ECO:0000269|PubMed:9003778}.
uniprot
proteins
amino_acid_sequence
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
uniprot
proteins
ec_number
2.7.12.2
uniprot
proteins
function
FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269|PubMed:7716521}.
uniprot
proteins
mass_dalton
44288
uniprot
proteins
post_translational_modification
PTM: Activated by phosphorylation on Ser-257 and Thr-261 by MAP kinase kinase kinases (MAP3Ks). {ECO:0000269|PubMed:9003778}.
uniprot
proteins
protein_family
MAP kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
11090355
uniprot
proteins
pubmed
11104681
uniprot
proteins
pubmed
12189133
uniprot
proteins
pubmed
12788955
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15866172
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17496909
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19782076
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20732303
uniprot
proteins
pubmed
20801953
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21333379
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7716521
uniprot
proteins
pubmed
7839144
uniprot
proteins
pubmed
9003778
uniprot
proteins
pubmed
9622070
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins