Duox1
entrez
266807
canonical
uniprot
Q8CIY2
canonical
ensembl
ENSRNOG00000033348
resolver
ensp
ENSRNOP00000045928
resolver
enst
ENSRNOT00000046843
resolver
genesymbol
Duox1
resolver
uniprot
F1M6V7
resolver
uniprot_entry
DUOX1_RAT
resolver
uniprot_entry
F1M6V7_RAT
resolver
activity_regulation
ACTIVITY REGULATION: The NADPH oxidase activity is calcium-dependent. It is activated by release of cellular ATP which is promoted by bacterial infection. Peroxidase activity is inhibited by aminobenzohydrazide. {ECO:0000250|UniProtKB:Q9NRD9}.
uniprot
proteins
amino_acid_sequence
MAVYSAVAWILLFGVLASLGAQNPVSWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLREPYLPNPRHLSNRVMRGPAGQPSLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIYIPRGDPVFDPDKRGNVVLPFQRSRWDRSTGQSPSNPRDLTNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPRNSQNSLLMWMAPDPATGQGGPQGLYAFGAQRGNREPFLQALGLLWFRYHNLCAKRLAQEHPHWGDEELFQHARKRVIATYQNIAMYEWLPSFLKQTPPEYPGYHPFLDPSISPEFVVASEQFLSTMVPPGVYMRNASCHFQGIANRNSSVSGALRVCNSYWSRENPKLQRAEDVDALLLGMASQIAEREDHLVVEDVQDFWPGPLKFSRTDYLASCLQRGRDLGLPSYTKAREALGLPPVSHWQDINPALSRSNGTVLEATAALYNQDLSRLELLAGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENNRNGLFSKEEIAEIRNTSLRDILVAVTNVDPSALQPSVFFWLAGDPCPQPSQLSTQGLPACAPLFVRDYFKGSGFGFGLTIGTLCCFPLVSLLSAWIVARLRMRNFKRLQRQDRQSIMCEKLVGGVEALEWQGRKEPCRPVLVHLQPGQIRVVDGRLTVLRTIQLRPPQQVNLILSSNRGRRTLLLKIPKEYDLVLLFNMEEERQALVENIRAALKENGLSFQEWELREQELMRAAVTRQQRGHLLETFFRHLFSQVLDINQADAGTLPLDSSTKVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKDQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGVEVPEVIKNLCRRASYISQEKICPSPRMSAHCARNNTKTASSPQRLQCPVDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSRRHQTVQQFKRFIENYRRHIGCVAVFYTITGALFLERAYYYAFAAHHSGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRFIASTAIILTVLHSAGHVVNVYLFSISPLSVLSCLFPDLFHDDGSEFPQKYYWWFFQTVPGLTGVLLLLALAIMYVFASHHFRRRSFRGFWLTHHLYIFLYILLIIHGSFALIQMPRFHIFFLVPAIIYVGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSPPTGDTCARYPKLYLDGPFGEGHQEWHKFEVSVLVGAGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDSRDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSVTHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINKQDRTHFSHHYENF
uniprot
proteins
ec_number
1.-.-.-
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
ec_number
1.6.3.1
uniprot
proteins
function
FUNCTION: Generates hydrogen peroxide (H2O2) which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO (PubMed:17643428). Plays a role in thyroid hormone synthesis (By similarity). Also required for lactoperoxidase-mediated antimicrobial defense at the surface of mucosa (By similarity). Antimicrobial agent hypothiocyanite (OSCN-), which is produced by LPO from DUOX1-derived H2O2, promotes influenza virus inactivation by reducing viral binding to and entry into host cells (By similarity). Promotes antiviral immunity by increasing airway cytokine levels, promoting innate immune cell recruitment and reducing airway epithelial cell apoptosis (By similarity). In response to bacterial stimuli, activated by ATP and promotes EGFR/ERK signaling, ADAM17 activation, and EGFR ligand shedding, leading to enhanced CXCL8/IL8 expression and secretion in airway epithelia (By similarity). Synthesizes NAADP from its reduced NAADPH form which promotes Ca(2+) signaling during T cell activation (By similarity). In addition to its oxidase activity, has also been shown to have peroxidase activity through its N-terminal peroxidase-like domain (By similarity). However, another study showed that the isolated peroxidase-like domain does not bind heme and has no intrinsic peroxidase activity (By similarity). {ECO:0000250|UniProtKB:A2AQ92, ECO:0000250|UniProtKB:Q9NRD9, ECO:0000269|PubMed:17643428}.
uniprot
proteins
mass_dalton
177197
uniprot
proteins
pathway_participation
PATHWAY: Hormone biosynthesis; thyroid hormone biosynthesis.
uniprot
proteins
protein_family
Peroxidase family
uniprot
proteins
pubmed
10806195
uniprot
proteins
pubmed
12538618
uniprot
proteins
pubmed
17643428
uniprot
proteins
sequence_length
1551
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9NRD9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NRD9}. Note=Localizes to the apical membrane of epithelial cells. {ECO:0000250|UniProtKB:Q9NRD9}.
uniprot
proteins
transmembrane_region
TRANSMEM 592..616; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NRD9"; TRANSMEM 1044..1066; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NRD9"; TRANSMEM 1081..1105; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NRD9"; TRANSMEM 1128..1152; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NRD9"; TRANSMEM 1185..1210; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NRD9"; TRANSMEM 1223..1241; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NRD9"; TRANSMEM 1249..1262; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NRD9
uniprot
proteins