Fzd3
entrez
14365
canonical
uniprot
Q61086
canonical
ensembl
ENSMUSG00000007989
resolver
ensp
ENSMUSP00000115325
resolver
enst
ENSMUST00000131309
resolver
genesymbol
Fzd3
resolver
uniprot_entry
FZD3_MOUSE
resolver
amino_acid_sequence
MAVSWIVFDLWLLTVFLGQIGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLVDLNLVGDPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFLHVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASSPAQYKASTVTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILFLMKYLMALIVGIPSIFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLRDPNTPIIRKSRGTSTQGTSTHASSTQLAMVDDQRSKAGSVHSKVSSYHGSLHRSRDGRYTPCSYRGMEERLPHGSMSRLTDHSRHSSSHRLNEQSRHSSIRDLSNNPMTHITHGTSMNRVIEEDGTSA
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. Activation by Wnt5A stimulates PKC activity via a G protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner. {ECO:0000269|PubMed:12351730, ECO:0000269|PubMed:14671310, ECO:0000269|PubMed:16407530, ECO:0000269|PubMed:16495441, ECO:0000269|PubMed:21325504, ECO:0000269|PubMed:24347548, ECO:0000269|PubMed:24799694}.
uniprot
proteins
mass_dalton
76208
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
10395542
uniprot
proteins
pubmed
11407985
uniprot
proteins
pubmed
12351730
uniprot
proteins
pubmed
14671310
uniprot
proteins
pubmed
16407530
uniprot
proteins
pubmed
16495441
uniprot
proteins
pubmed
16687519
uniprot
proteins
pubmed
21325504
uniprot
proteins
pubmed
24347548
uniprot
proteins
pubmed
24799694
uniprot
proteins
pubmed
8626800
uniprot
proteins
sequence_length
666
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell surface {ECO:0000269|PubMed:16495441}. Apical cell membrane {ECO:0000269|PubMed:16495441}; Multi-pass membrane protein. Note=Colocalizes with FZD6 at the apical face of the cell. {ECO:0000269|PubMed:16495441}.
uniprot
proteins
transmembrane_region
TRANSMEM 206..226; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 329..349; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 375..395; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 421..441; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 478..498; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins