Lgr5
entrez
14160
canonical
uniprot
Q9Z1P4
canonical
ensembl
ENSMUSG00000020140
resolver
ensp
ENSMUSP00000020350
resolver
enst
ENSMUST00000020350
resolver
genesymbol
Lgr5
resolver
genesymbol_syn
Fex
resolver
genesymbol_syn
Gpr49
resolver
uniprot
Q3V1L2
resolver
uniprot_entry
LGR5_MOUSE
resolver
uniprot_sec
Q3V1L2
resolver
amino_acid_sequence
MDTSCVHMLLSLLALLQLVAAGSSPGPDAIPRGCPSHCHCELDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLPASLLHRLCFLEELRLAGNALTHIPKGAFTGLHSLKVLMLQNNQLRQVPEEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTDVPVQAFRSLSALQAMTLALNKIHHIADYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIKTLSNLKELGFHSNNIRSIPERAFVGNPSLITIHFYDNPIQFVGVSAFQHLPELRTLTLNGASHITEFPHLTGTATLESLTLTGAKISSLPQAVCDQLPNLQVLDLSYNLLEDLPSLSGCQKLQKIDLRHNEIYEIKGSTFQQLFNLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPVTGLHGLTHLKLTGNRALQSLIPSANFPELKIIEMPSAYQCCAFGGCENVYKISNQWNKDDGNSVDDLHKKDAGLFQVQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLFGSWLIRIGVWTTAVLALSCNALVALTVFRTPLYISSIKLLIGVIAVVDILMGVSSAVLAAVDAFTFGRFAQHGAWWEDGIGCQIVGFLSIFASESSIFLLTLAALERGFSVKCSSKFEVKAPLFSLRAIVLLCVLLALTIATIPLLGGSKYNASPLCLPLPFGEPSTTGYMVALVLLNSLCFLIMTIAYTKLYCSLEKGELENLWDCSMVKHIALLLFANCILYCPVAFLSFSSLLNLTFISPDVIKFILLVIVPLPSCLNPLLYIVFNPHFKEDMGSLGKHTRFWMRSKHASLLSINSDDVEKRSCESTQALVSFTHASIAYDLPSTSGASPAYPMTESCHLSSVAFVPCL
uniprot
proteins
function
FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21727895}.
uniprot
proteins
mass_dalton
99666
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15509778
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17934449
uniprot
proteins
pubmed
18849992
uniprot
proteins
pubmed
21727895
uniprot
proteins
pubmed
22510880
uniprot
proteins
pubmed
29769720
uniprot
proteins
pubmed
9920770
uniprot
proteins
sequence_length
907
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 562..582; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 594..614; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 639..659; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 683..703; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 724..744; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 768..788; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 803..823; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins