Stard7
entrez
99138
canonical
uniprot
Q8R1R3
canonical
ensembl
ENSMUSG00000027367
resolver
ensp
ENSMUSP00000106004
resolver
ensp
ENSMUSP00000268894
resolver
enst
ENSMUST00000110375
resolver
genesymbol
Stard7
resolver
uniprot
A2ARG0
resolver
uniprot_entry
STAR7_MOUSE
resolver
uniprot_sec
A2ARG0
resolver
amino_acid_sequence
MFPRRPPATLAAWLAGARGGGLLSALANQCRFVTGLRVRRAQQIAQLYGRLYSESSRCALLGRFWRRLRGRPGHASVLMAALSGVFVWDEERIQEEELQRSINEMKRLEEMSNIFQSSGVENYPPEPKSPAGGNEKSKDKEEPWEMVMDKKHFKLWRRPITGTHLYQYRVFGTYTDVTPRQFFNVQLDTEYRKKWDALVIKLEVIERDAVSGSEVLHWVTHFPYPMYSRDYVYVRRYSVDQENNVMVLVSRAVEHPSVPESPEFVRVRSYESQMVIRPHKSFDENGFDYLLTYSDNPQTVFPRYCVSWMVSSGMPDFLEKLHMATLKAKNMEIKVKDYISAKPLEMSSEAKATAPSPERKNEGSCGPARIEYA
uniprot
proteins
function
FUNCTION: Mediates non-vesicular transfer of phosphatidylcholine to mitochondria, thereby maintaining mitochondrial membrane lipid composition, cristae organization, and respiratory function across diverse tissues. {ECO:0000269|PubMed:28401922, ECO:0000269|PubMed:32071354}.; FUNCTION: [StAR-related lipid transfer protein 7, mitochondrial]: Transfers phosphatidylcholine (PC) from the endoplasmic reticulum to the mitochondrial outer membrane at ER-mitochondria contact sites, thereby maintaining mitochondrial PC content, respiratory complex stability and mitochondrial cristae morphology. {ECO:0000269|PubMed:32071354}.; FUNCTION: [StAR-related lipid transfer protein 7, mature]: Phosphatidylcholine (PC) transfer protein that operates in two distinct forms: a cytosolic form and a mitochondrial intermembrane space (IMM) form. Both mature forms facilitate non-vesicular PC transport by transiently associating with mitochondrial membranes. The mitochondrial intermembrane space (IMM) form supports lipid exchange between the outer and inner mitochondrial membranes. Through this activity, the protein is essential for maintaining mitochondrial lipid homeostasis, preserving normal cristae architecture, and ensuring optimal respiratory chain function (PubMed:32071354). Mediates intracellular distribution of coenzyme Q (ubiquinone), the intermembrane space form supports mitochondrial coenzyme Q biosynthesis and the cytosolic form transfers coenzyme Q to extramitochondrial membranes, enhancing antioxidant protection and limiting ferroptosis sensitivity (PubMed:36658222). {ECO:0000269|PubMed:32071354, ECO:0000269|PubMed:36658222}.
uniprot
proteins
mass_dalton
43144
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by PARL. Mitochondrial targeting sequence is cleaved off by the mitochondrial processing peptidase YME1L1 in the mitochondrial matrix, generating an intermediate form. The intermediate form is cleaved within the transmembrane segment by the intramembrane protease PARL, producing the mature form of STARD7 which is released from the inner mitochondrial membrane and undergoes retro-translocation to the cytosol and/or internalization into the mitochondrion intermembrane space (IMS) (By similarity). It seems that cleavage by PARL doesn't take place in myoblasts (PubMed:32071354). {ECO:0000250|UniProtKB:Q9NQZ5, ECO:0000269|PubMed:32071354}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25980009
uniprot
proteins
pubmed
27694445
uniprot
proteins
pubmed
28401922
uniprot
proteins
pubmed
32071354
uniprot
proteins
pubmed
36658222
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [StAR-related lipid transfer protein 7, mitochondrial]: Mitochondrion outer membrane {ECO:0000269|PubMed:32071354}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9NQZ5}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9NQZ5}.; SUBCELLULAR LOCATION: [StAR-related lipid transfer protein 7, mature]: Mitochondrion intermembrane space {ECO:0000269|PubMed:32071354}. Cytoplasm, cytosol {ECO:0000269|PubMed:32071354}. Note=Precursor form is imported into mitochondria via the TOM and TIM23 complexes. After sequential cleavages by YME1L1 and PARL, mature form is released from the inner membrane and dynamically localizes to the cytosol and mitochondrial intermembrane space, where it associates transiently with the outer mitochondrial membrane to mediate phosphatidylcholine (PC) transfer between mitochondrial membranes. {ECO:0000250|UniProtKB:Q9NQZ5}.
uniprot
proteins
transmembrane_region
TRANSMEM 63..99; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NQZ5
uniprot
proteins