Homer1
entrez
26556
canonical
uniprot
Q9Z2Y3
canonical
ensembl
ENSMUSG00000007617
resolver
ensp
ENSMUSP00000050471
resolver
ensp
ENSMUSP00000078093
resolver
ensp
ENSMUSP00000079026
resolver
ensp
ENSMUSP00000099813
resolver
ensp
ENSMUSP00000105118
resolver
ensp
ENSMUSP00000105120
resolver
enst
ENSMUST00000109494
resolver
genesymbol
Homer1
resolver
genesymbol_syn
Vesl1
resolver
uniprot
F6YYQ1
resolver
uniprot
Q3UVL6
resolver
uniprot
Q5D052
resolver
uniprot
Q8K3E1
resolver
uniprot
Q8K4M8
resolver
uniprot
Q9Z0E9
resolver
uniprot
Q9Z216
resolver
uniprot_entry
F6YYQ1_MOUSE
resolver
uniprot_entry
HOME1_MOUSE
resolver
uniprot_entry
Q3UVL6_MOUSE
resolver
uniprot_entry
Q5D052_MOUSE
resolver
uniprot_sec
Q8K3E1
resolver
uniprot_sec
Q8K4M8
resolver
uniprot_sec
Q9Z0E9
resolver
uniprot_sec
Q9Z216
resolver
amino_acid_sequence
MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFPHSAGDRTQALSHASSAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHSHKTELNQTVQELEETLKVKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQEAFRSNLKTLLEILDGKIFELTELRDNLAKLLECS
uniprot
proteins
function
FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 5 counteracts the effects by competing for binding sites. Isoform 3 regulates the trafficking and surface expression of GRM5. Isoform 5 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, isoform 2 and isoform 3 to regulate synaptic metabotropic glutamate function. Isoform 5, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development (By similarity). Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q86YM7, ECO:0000250|UniProtKB:Q9Z214}.
uniprot
proteins
mass_dalton
41413
uniprot
proteins
protein_family
Homer family
uniprot
proteins
pubmed
10851183
uniprot
proteins
pubmed
12176012
uniprot
proteins
pubmed
12379179
uniprot
proteins
pubmed
17107665
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21558424
uniprot
proteins
pubmed
24153177
uniprot
proteins
pubmed
25979765
uniprot
proteins
pubmed
27373832
uniprot
proteins
pubmed
9808458
uniprot
proteins
pubmed
9808459
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24153177}. Postsynaptic density {ECO:0000269|PubMed:24153177}. Synapse {ECO:0000269|PubMed:24153177}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z214}. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. The N-terminal of isoform 2 may facilitate trafficking of the complex with GRM5 from the endoplasmic reticulum (ER) to the plasma membrane (PM).
uniprot
proteins