MKRN2
entrez
23609
canonical
uniprot
Q9H000
canonical
ensembl
ENSG00000075975
resolver
ensp
ENSP00000170447
resolver
ensp
ENSP00000396340
resolver
genesymbol
MKRN2
resolver
genesymbol_syn
RNF62
resolver
hgnc
HGNC:7113
resolver
uniprot
A6NIA2
resolver
uniprot
B3KRC5
resolver
uniprot
B4DPR4
resolver
uniprot
Q8N391
resolver
uniprot
Q96BD4
resolver
uniprot
Q9BUY2
resolver
uniprot
Q9NRY1
resolver
uniprot_entry
MKRN2_HUMAN
resolver
uniprot_sec
A6NIA2
resolver
uniprot_sec
B3KRC5
resolver
uniprot_sec
B4DPR4
resolver
uniprot_sec
Q8N391
resolver
uniprot_sec
Q96BD4
resolver
uniprot_sec
Q9BUY2
resolver
uniprot_sec
Q9NRY1
resolver
amino_acid_sequence
MSTKQITCRYFMHGVCREGSQCLFSHDLANSKPSTICKYYQKGYCAYGTRCRYDHTRPSAAAGGAVGTMAHSVPSPAFHSPHPPSEVTASIVKTNSHEPGKREKRTLVLRDRNLSGMAERKTQPSMVSNPGSCSDPQPSPEMKPHSYLDAIRSGLDDVEASSSYSNEQQLCPYAAAGECRFGDACVYLHGEVCEICRLQVLHPFDPEQRKAHEKICMLTFEHEMEKAFAFQASQDKVCSICMEVILEKASASERRFGILSNCNHTYCLSCIRQWRCAKQFENPIIKSCPECRVISEFVIPSVYWVEDQNKKNELIEAFKQGMGKKACKYFEQGKGTCPFGSKCLYRHAYPDGRLAEPEKPRKQLSSQGTVRFFNSVRLWDFIENRESRHVPNNEDVDMTELGDLFMHLSGVESSEP
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity). Plays a role in the regulation of spermiation and in male fertility (By similarity). {ECO:0000250|UniProtKB:Q9ERV1}.
uniprot
proteins
mass_dalton
46940
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11597136
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28008940
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9ERV1}. Nucleus {ECO:0000250|UniProtKB:Q9ERV1}.
uniprot
proteins