Tradd
entrez
71609
canonical
uniprot
Q3U0V2
canonical
ensembl
ENSMUSG00000031887
resolver
ensp
ENSMUSP00000034359
resolver
enst
ENSMUST00000034359
resolver
genesymbol
Tradd
resolver
uniprot
B2RRZ7
resolver
uniprot_entry
B2RRZ7_MOUSE
resolver
uniprot_entry
TRADD_MOUSE
resolver
amino_acid_sequence
MAAGQNGHEEWVGSAYLFLESAVDKVILSEAYTDPKKKVAIYKALQTALSESGDSSDVLQILKIHCSDPQLIVQLRFCGRVLCGRFLQAYREGALRTALQRCMAPALAQEALRLQLELRAGAEQLDSWLTDEERCLNYILAQKPDRLRDEELAELEDELCKLTCDCTGQGGAIQVASAGSKFPVSSPTEEKPLPAACQTFLFHGQLVVNRPLTLQDQQTFARSVGLKWRRVGRSLQRNCRALRDPALDSLAYEYERDGLYEQAFQLLRRFMQAEGRRATLQRLVEALEENELTSLAEDLLGQAEPDGGLA
uniprot
proteins
function
FUNCTION: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD (By similarity). Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (By similarity). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (PubMed:22561347). {ECO:0000250|UniProtKB:Q15628, ECO:0000269|PubMed:22561347}.
uniprot
proteins
mass_dalton
34577
uniprot
proteins
mutagenesis
MUTAGEN 297..299; /note="EDL->AAA: Dominant-negative mutant, leading to enhanced ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A."; /evidence="ECO:0000269|PubMed:22561347
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Glycosylated at Arg-243 by S.typhimurium protein Ssek1: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions and assembly of the oligomeric TNFRSF1A/TNFR1 complex, thereby disrupting TNF signaling. {ECO:0000269|PubMed:30902834}.
uniprot
proteins
pubmed
14585990
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16702408
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22561347
uniprot
proteins
pubmed
30185824
uniprot
proteins
pubmed
30902834
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22561347}. Cytoplasm {ECO:0000269|PubMed:22561347}. Cytoplasm, cytoskeleton. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000269|PubMed:22561347}.
uniprot
proteins