Polg2
entrez
50776
canonical
uniprot
Q9QZM2
canonical
ensembl
ENSMUSG00000020718
resolver
ensp
ENSMUSP00000021060
resolver
enst
ENSMUST00000021060
resolver
genesymbol
Polg2
resolver
genesymbol_syn
Mtpolb
resolver
uniprot
B1ARB5
resolver
uniprot
O35614
resolver
uniprot
Q0VES3
resolver
uniprot
Q3V3E7
resolver
uniprot_entry
DPOG2_MOUSE
resolver
uniprot_entry
Q0VES3_MOUSE
resolver
uniprot_entry
Q3V3E7_MOUSE
resolver
uniprot_sec
B1ARB5
resolver
uniprot_sec
O35614
resolver
amino_acid_sequence
MRCGGGARACRRACRCWLSGYAGPADGTQQPDAPEHAVAREALVDLCRRRHFFSGTPQQLSTAALLSGCHARFGPLGVELRKNLASQWWSSMVVFREQVFAVDSLHQEPGSSQPRDSAFRLVSPESIREILQDREPSKEQLVAFLENLLKTSGKLRATLLHGALEHYVNCLDLVNRKLPFGLAQIGVCFHPVSNSNQTPSSVTRVGEKTEASLVWFTPTRTSSQWLDFWLRHRLLWWRKFAMSPSNFSSADCQDELGRKGSKLYYSFPWGKEPIETLWNLGDQELLHTYPGNVSTIQGRDGRKNVVPCVLSVSGDVDLGTLAYLYDSFQLAENSFARKKSLQRKVLKLHPCLAPIKVALDVGKGPTVELRQVCQGLLNELLENGISVWPGYSETVHSSLEQLHSKYDEMSVLFSVLVTETTLENGLIQLRSRDTTMKEMMHISKLRDFLVKYLASASNV
uniprot
proteins
function
FUNCTION: Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA. {ECO:0000250|UniProtKB:Q9UHN1}.
uniprot
proteins
mass_dalton
51467
uniprot
proteins
pubmed
10666468
uniprot
proteins
pubmed
11172710
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P54098}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:P54098}.
uniprot
proteins