Sdc1
entrez
25216
canonical
uniprot
P26260
canonical
ensembl
ENSRNOG00000059947
resolver
ensembl
ENSRNOG00055005732
resolver
ensembl
ENSRNOG00060003626
resolver
ensembl
ENSRNOG00065005294
resolver
ensp
ENSRNOP00000104961
resolver
ensp
ENSRNOP00055007098
resolver
ensp
ENSRNOP00060004390
resolver
ensp
ENSRNOP00065005441
resolver
enst
ENSRNOT00055009257
resolver
enst
ENSRNOT00060005969
resolver
enst
ENSRNOT00065007815
resolver
genesymbol
Sdc1
resolver
genesymbol_syn
Synd1
resolver
uniprot_entry
SDC1_RAT
resolver
amino_acid_sequence
MRRAALWLWLCALALRLQPALPQIVTANVPPEDQDGSGDDSDNFSGSGTGALPDMTLSRQTPSTWKDVWLLTATPTAPEPTSRDTEATLTSILPAGEKPEEGEPVAHVEAEPDFTARDKEKEATTRPRETTQLPVTQQASTAARATTAQASVTSHPHGDVQPGLHETLAPTAPGQPDHQPPSVEDGGTSVIKEVVEDETTNQLPAGEGSGEQDFTFETSGENTAVAGVEPDLRNQSPVDEGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVAFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA
uniprot
proteins
function
FUNCTION: Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (By similarity). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). {ECO:0000250|UniProtKB:P18827, ECO:0000250|UniProtKB:P18828}.
uniprot
proteins
mass_dalton
33214
uniprot
proteins
post_translational_modification
PTM: Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3 (By similarity). {ECO:0000250|UniProtKB:P18827}.
uniprot
proteins
protein_family
Syndecan proteoglycan family
uniprot
proteins
pubmed
1537865
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1639809
uniprot
proteins
pubmed
8495865
uniprot
proteins
pubmed
9089390
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:P18827}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P18827}. Note=Shedding of the ectodomain produces a soluble form. {ECO:0000250|UniProtKB:P18827}.
uniprot
proteins
transmembrane_region
TRANSMEM 258..278; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins