DPEP2
entrez
64174
canonical
uniprot
Q9H4A9
canonical
ensembl
ENSG00000167261
resolver
ensp
ENSP00000377430
resolver
ensp
ENSP00000458977
resolver
ensp
ENSP00000537103
resolver
ensp
ENSP00000537106
resolver
ensp
ENSP00000537107
resolver
ensp
ENSP00000640227
resolver
ensp
ENSP00000760467
resolver
genesymbol
DPEP2
resolver
hgnc
HGNC:23028
resolver
uniprot
A0A024R6Y5
resolver
uniprot
B2RCF8
resolver
uniprot
B3KS59
resolver
uniprot
I3L248
resolver
uniprot
Q6UX92
resolver
uniprot
Q8TC95
resolver
uniprot_entry
DPEP2_HUMAN
resolver
uniprot_sec
A0A024R6Y5
resolver
uniprot_sec
B2RCF8
resolver
uniprot_sec
B3KS59
resolver
uniprot_sec
I3L248
resolver
uniprot_sec
Q6UX92
resolver
uniprot_sec
Q8TC95
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by L-penicillamine. {ECO:0000250|UniProtKB:Q8C255}.
uniprot
proteins
amino_acid_sequence
MQPSGLEGPGTFGRWPLLSLLLLLLLLQPVTCAYTTPGPPRALTTLGAPRAHTMPGTYAPSTTLSSPSTQGLQEQARALMRDFPLVDGHNDLPLVLRQVYQKGLQDVNLRNFSYGQTSLDRLRDGLVGAQFWSAYVPCQTQDRDALRLTLEQIDLIRRMCASYSELELVTSAKALNDTQKLACLIGVEGGHSLDNSLSILRTFYMLGVRYLTLTHTCNTPWAESSAKGVHSFYNNISGLTDFGEKVVAEMNRLGMMVDLSHVSDAVARRALEVSQAPVIFSHSAARGVCNSARNVPDDILQLLKKNGGVVMVSLSMGVIQCNPSANVSTVADHFDHIKAVIGSKFIGIGGDYDGAGKFPQGLEDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENKWQSPLEDKFPDEQLSSSCHSDLSRLRQRQSLTSGQELTEIPIHWTAKLPAKWSVSESSPHMAPVLAVVATFPVLILWL
uniprot
proteins
ec_number
3.4.13.19
uniprot
proteins
function
FUNCTION: Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (PubMed:32325220). Hydrolyzes cystinyl-bis-glycine (PubMed:32325220). {ECO:0000269|PubMed:32325220}.; FUNCTION: Independently of its dipeptidase activity can also modulate macrophage inflammatory response by acting as a regulator of NF-kappaB inflammatory signaling pathway. {ECO:0000250|UniProtKB:Q8C255}.
uniprot
proteins
mass_dalton
53365
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
protein_family
Peptidase M19 family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
32325220
uniprot
proteins
sequence_length
486
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8C255}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q8C255}.
uniprot
proteins