Iho1
entrez
434438
canonical
uniprot
Q6PDM4
canonical
ensembl
ENSMUSG00000047220
resolver
ensp
ENSMUSP00000075898
resolver
ensp
ENSMUSP00000201795
resolver
ensp
ENSMUSP00000201796
resolver
ensp
ENSMUSP00000339529
resolver
enst
ENSMUST00000076592
resolver
genesymbol
Iho1
resolver
genesymbol_syn
Ccdc36
resolver
uniprot_entry
IHO1_MOUSE
resolver
amino_acid_sequence
MNFNVWNVKEMLSIPSGSGITKPSNWNNNQTDCSLSDSQFLFGSQFCPENSETLLPSLDAGACLRHPKQTQQNSVDSEPSIFIKYQAKPQLLGGDTKDESLFSLPLPVGKSKGLSKQFEEKKRRATDQSDSETLHSFVSHFPEVINKLQTSVEKTEENLSSRSQSILDSVETIAKTFQETARVQHDLMVESVRDKGSMEQAILEIQRTCAARQAEFMEMKSTLKNLEVLVVEQTKNLQQFCDNLSQLIVPGILEELKKFTSVPQVAGHLKDSTSQTSPSLTQSLHFTRQEKHPSEEPATWQAQEAPAGNPSTSSQRPGECGVWDEGAESGVFQKAALPTDGLHRGDGHVKNKTVPTYCKNWVMTTRSVSNHFSNLPSQRAGNGQGLMAQGASQRDVSKFEARVKNACPEYGPQSMCSFDSLEQSATEQKGRPCRKRRRGKKQQPQRSKRGGLLDRKQGQTSKAACAFIARHHCPQSPVCDPQGPLICWLTPRSSTKSTCHILGGTGETSQTARAAQGNLVQHSQRSSTDSSSQGDQQINWFSDLSLENLEPPQCKKGGTNLLCDPDFDSSDDNF
uniprot
proteins
function
FUNCTION: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:27723721). Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721). Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance (PubMed:27723721). {ECO:0000269|PubMed:27723721}.
uniprot
proteins
mass_dalton
63340
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27723721
uniprot
proteins
pubmed
30569039
uniprot
proteins
pubmed
31000436
uniprot
proteins
sequence_length
574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:27723721}. Note=Specifically localizes to unsynapsed chromosomal regions during meiosis (PubMed:27723721). Appears on chromatin during preleptotene, when pre-meiotic replication occurs and axes have not yet developed (PubMed:27723721). Remains associated with unsynapsed axesn zygotene, when axes elongate and synapsis begins but disappears from synapsed axes (PubMed:27723721). Localization diverges in the two sexes beyond zygotene (PubMed:27723721). In spermatocytes, synapsis between the largely non-homologous X and Y chromosomes is mostly constrained to their short pseudoautosomal regions (PARs) (PubMed:27723721). At the zygotene-to-pachytene transition, high levels remain on unsynapsed sex chromosome axes but also on PARs (PubMed:27723721). However, by early pachytene disappears from both the synapsed and unsynapsed regions of sex chromosomes (PubMed:27723721). Reaccumulates on unsynapsed axes of sex chromosomes in mid-late pachytene and on desynapsing autosome axes in diplotene, but disappears from chromatin concomitant with axis disassembly after diplotene (PubMed:27723721). In oocytes, disappears from axes after all chromosomes synapsed and is undetectable on chromatin beyond zygotene (PubMed:27723721). Ovarian levels also dramatically decrease as oocytes progress to late prophase (PubMed:27723721). HORMAD1 is required for robust accumulation on chromatin and unsynapsed axes, suggesting that HORMAD1 recruits IHO1 to unsynapsed axes (PubMed:27723721). {ECO:0000269|PubMed:27723721}.
uniprot
proteins