CDHR3
entrez
222256
canonical
uniprot
Q6ZTQ4
canonical
ensembl
ENSG00000128536
resolver
ensp
ENSP00000325954
resolver
ensp
ENSP00000417771
resolver
enst
ENST00000478080
resolver
genesymbol
CDHR3
resolver
genesymbol_syn
CDH28
resolver
hgnc
HGNC:26308
resolver
uniprot
B7Z8X2
resolver
uniprot
E7EQG5
resolver
uniprot
Q8TCI7
resolver
uniprot_entry
B7Z8X2_HUMAN
resolver
uniprot_entry
CDHR3_HUMAN
resolver
uniprot_entry
E7EQG5_HUMAN
resolver
uniprot_sec
Q8TCI7
resolver
amino_acid_sequence
MQEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGSILLLGLLVYLVVLLAKAIHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGEAIDPVTGETYEFNSKTGARKWKDPLTQMPKWKESSHQGAAPRRVTAGEGMGSLRSANWEEDELSGKAWAEDAGLGSRNEGGKLGNPKNRNPAFMNRAYPKPHPGK
uniprot
proteins
disease_involvement
DISEASE: Note=Asthma susceptibility may be associated with variants affecting the gene represented in this entry in early childhood asthma with severe exacerbations occurring between 2 and 6 years of age. {ECO:0000269|PubMed:24241537}.
uniprot
proteins
function
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.; FUNCTION: (Microbial infection) Acts as a receptor for human rhinovirus C. {ECO:0000269|PubMed:25848009, ECO:0000269|PubMed:32152109}.
uniprot
proteins
mass_dalton
97977
uniprot
proteins
mutagenesis
MUTAGEN 26; /note="P->A: Complete loss of interaction with human rhinovirus C."; /evidence="ECO:0000269|PubMed:32152109"; MUTAGEN 100; /note="I->A: Complete loss of interaction with human rhinovirus C."; /evidence="ECO:0000269|PubMed:32152109"; MUTAGEN 102; /note="D->A,N: Complete loss of interaction with human rhinovirus C."; /evidence="ECO:0000269|PubMed:32152109"; MUTAGEN 118; /note="V->G: Complete loss of interaction with human rhinovirus C."; /evidence="ECO:0000269|PubMed:32152109
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24241537
uniprot
proteins
pubmed
25848009
uniprot
proteins
pubmed
32152109
uniprot
proteins
sequence_length
885
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24241537}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 714..734; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins