Atg5
entrez
11793
canonical
uniprot
Q99J83
canonical
ensembl
ENSMUSG00000038160
resolver
ensp
ENSMUSP00000044769
resolver
ensp
ENSMUSP00000199689
resolver
ensp
ENSMUSP00000199698
resolver
ensp
ENSMUSP00000199703
resolver
ensp
ENSMUSP00000199705
resolver
enst
ENSMUST00000039286
resolver
genesymbol
Atg5
resolver
genesymbol_syn
Apg5l
resolver
uniprot_entry
ATG5_MOUSE
resolver
amino_acid_sequence
MTDDKDVLRDVWFGRIPTCFTLYQDEITEREAEPYYLLLPRVSYLTLVTDKVKKHFQKVMRQEDVSEIWFEYEGTPLKWHYPIGLLFDLLASSSALPWNITVHFKSFPEKDLLHCPSKDAVEAHFMSCMKEADALKHKSQVINEMQKKDHKQLWMGLQNDRFDQFWAINRKLMEYPPEENGFRYIPFRIYQTTTERPFIQKLFRPVAADGQLHTLGDLLREVCPSAVAPEDGEKRSQVMIHGIEPMLETPLQWLSEHLSYPDNFLHISIVPQPTD
uniprot
proteins
function
FUNCTION: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. As part of the ATG8 conjugation system with ATG12 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (PubMed:38227290). {ECO:0000269|PubMed:11266458, ECO:0000269|PubMed:12890687, ECO:0000269|PubMed:17190837, ECO:0000269|PubMed:17912025, ECO:0000269|PubMed:18188005, ECO:0000269|PubMed:19844159, ECO:0000269|PubMed:20171125, ECO:0000269|PubMed:24089205, ECO:0000269|PubMed:24089209, ECO:0000269|PubMed:38227290}.; FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD (By similarity). {ECO:0000250|UniProtKB:Q9H1Y0}.; FUNCTION: (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection. {ECO:0000269|PubMed:17709747}.
uniprot
proteins
mass_dalton
32402
uniprot
proteins
mutagenesis
MUTAGEN 130; /note="K->R: Loss of conjugation."; /evidence="ECO:0000269|PubMed:11266458
uniprot
proteins
post_translational_modification
PTM: Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.; PTM: Acetylated by EP300. {ECO:0000250}.
uniprot
proteins
protein_family
ATG5 family
uniprot
proteins
pubmed
11266458
uniprot
proteins
pubmed
12482611
uniprot
proteins
pubmed
12665549
uniprot
proteins
pubmed
12890687
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17190837
uniprot
proteins
pubmed
17709747
uniprot
proteins
pubmed
17912025
uniprot
proteins
pubmed
18188005
uniprot
proteins
pubmed
18768753
uniprot
proteins
pubmed
19417210
uniprot
proteins
pubmed
19844159
uniprot
proteins
pubmed
20171125
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22082872
uniprot
proteins
pubmed
24089205
uniprot
proteins
pubmed
24089209
uniprot
proteins
pubmed
28231469
uniprot
proteins
pubmed
38227290
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24089209}. Preautophagosomal structure membrane {ECO:0000269|PubMed:24089209}; Peripheral membrane protein {ECO:0000269|PubMed:24089209}. Note=The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. Also localizes to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. Under starved conditions, the ATG12-ATG5-ATG16L1 complex is translocated to phagophores driven by RAB33B (By similarity). {ECO:0000250|UniProtKB:Q9H1Y0}.
uniprot
proteins