P85125
uniprot
P85125
canonical
amino_acid_sequence
MEDVTLHIVERPYSGYPDASSEGPEPTPGEARATEEPSGTGSDELIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFKVMIYQDEVKLPAKLSVSKSLKESEALPEKEGDELGEGERPEEDAAAIELSSDEAVEVEEVIEESRAERIKRSGLRRVDDFKKAFSKEKMEKTKVRTRENLEKTRLKTKENLEKTRHTLEKRMNKLGTRLVPVERREKLKTSRDKLRKSFTPDHVVYARSKTAVYKVPPFTFHVKKIREGEVEVLKATEMVEVGPDDDEVGAERGAETDLLRGSSPDVHTLLEITEESDAVLVDKSDSD
uniprot
proteins
function
FUNCTION: Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues. Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template. The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A. {ECO:0000250|UniProtKB:O54724}.
uniprot
proteins
mass_dalton
43909
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Present in active and inactive forms. Changes in phosphorylation pattern may alter activity. Phosphorylation at Tyr-158 is essential for its function in the regulation of ribosomal transcriptional activity. {ECO:0000250|UniProtKB:O54724}.; PTM: Monoubiquitinated. {ECO:0000250|UniProtKB:O54724}.
uniprot
proteins
protein_family
CAVIN family
uniprot
proteins
pubmed
11512676
uniprot
proteins
pubmed
11702238
uniprot
proteins
pubmed
16236245
uniprot
proteins
pubmed
18056712
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane, caveola {ECO:0000269|PubMed:11512676, ECO:0000269|PubMed:11702238, ECO:0000269|PubMed:16236245, ECO:0000269|PubMed:18056712}. Cell membrane {ECO:0000269|PubMed:11512676, ECO:0000269|PubMed:11702238, ECO:0000269|PubMed:16236245, ECO:0000269|PubMed:18056712}. Microsome {ECO:0000269|PubMed:11512676, ECO:0000269|PubMed:16236245}. Endoplasmic reticulum {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:11702238}. Mitochondrion {ECO:0000250|UniProtKB:Q6NZI2}. Nucleus {ECO:0000269|PubMed:11702238, ECO:0000269|PubMed:16236245}. Note=Translocates to the cytoplasm from the caveolae upon insulin stimulation (By similarity). Colocalizes with CAV1 in lipid rafts in adipocytes (PubMed:18056712). Localizes in the caveolae in a caveolin-dependent manner (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000250|UniProtKB:Q6NZI2, ECO:0000269|PubMed:18056712}.
uniprot
proteins