Tox4
entrez
268741
canonical
uniprot
Q8BU11
canonical
ensembl
ENSMUSG00000016831
resolver
ensp
ENSMUSP00000022766
resolver
enst
ENSMUST00000022766
resolver
genesymbol
Tox4
resolver
genesymbol_syn
mKIAA0737
resolver
uniprot
Q3UGN7
resolver
uniprot
Q3UVQ1
resolver
uniprot
Q6A006
resolver
uniprot
Q80UI2
resolver
uniprot
Q99PN9
resolver
uniprot
Q9CS16
resolver
uniprot_entry
Q3UVQ1_MOUSE
resolver
uniprot_entry
Q6A006_MOUSE
resolver
uniprot_entry
TOX4_MOUSE
resolver
uniprot_sec
Q3UGN7
resolver
uniprot_sec
Q80UI2
resolver
uniprot_sec
Q99PN9
resolver
uniprot_sec
Q9CS16
resolver
activity_regulation
ACTIVITY REGULATION: In liver, recruited to target gene promoters following treatment with dexamethasone and cAMP. Binding is decreased in presence of insulin. {ECO:0000269|PubMed:34914893}.
uniprot
proteins
amino_acid_sequence
MEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGMTHGLMEQGGGLLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTNSLHEDGVDDFRRQLPAQKTVVVETGKKQKAPKKRKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYKDNQECQATVETVELDPVPQSQTPSPPPVTAADPASPAPASTESPALPPCIIVNSTLSSYVANQASSGPGGQPNITKLIITKQMLPSSITMSQGGMVTVIPATVVTSRGLQVGQTSTATIQPSQQAQIVTRSVLQAAAAAAASMQLPPPRLQPPPLQQMPQPPTQQQVTILQQPPPLQAMQQPPPQKVRINLQQQPPPLQSKIVPPPTLKIQTTVVPPTVESSPEQPMNSSPEAHTVEATSPETICEMIADVVPEVESPSQMDVELVSGSPVALSPQPRCVRSGCENPPVVSKDWDNEYCSNECVVKHCRDVFLAWVASRNPNSVVFVK
uniprot
proteins
function
FUNCTION: Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (PubMed:31519808). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1 (PubMed:34914893). This regulation is independent of the insulin receptor activation (PubMed:34914893). Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes (PubMed:35365735). Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release (PubMed:35365735). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). {ECO:0000250|UniProtKB:O94842, ECO:0000269|PubMed:31519808, ECO:0000269|PubMed:34914893, ECO:0000269|PubMed:35365735}.
uniprot
proteins
mass_dalton
65961
uniprot
proteins
mutagenesis
MUTAGEN 213..218; /note="Missing: Loss of transcriptional regulation of gluconeogenic genes expression."; /evidence="ECO:0000269|PubMed:34914893
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
31519808
uniprot
proteins
pubmed
34914893
uniprot
proteins
pubmed
35365735
uniprot
proteins
pubmed
37286708
uniprot
proteins
sequence_length
619
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34914893}. Chromosome {ECO:0000269|PubMed:34914893, ECO:0000269|PubMed:35365735}. Note=Associated with chromatin; colocalizes with RNA polymerase II (Pol II) on chromatin. {ECO:0000269|PubMed:34914893, ECO:0000269|PubMed:35365735}.
uniprot
proteins