TRIM39
entrez
56658
canonical
uniprot
Q9HCM9
canonical
ensembl
ENSG00000204599
resolver
ensembl
ENSG00000206495
resolver
ensembl
ENSG00000224994
resolver
ensembl
ENSG00000226437
resolver
ensembl
ENSG00000229929
resolver
ensembl
ENSG00000230308
resolver
ensembl
ENSG00000232839
resolver
ensp
ENSP00000365844
resolver
ensp
ENSP00000365847
resolver
ensp
ENSP00000379797
resolver
ensp
ENSP00000379800
resolver
ensp
ENSP00000553640
resolver
genesymbol
TRIM39
resolver
genesymbol_syn
RNF23
resolver
genesymbol_syn
TFP
resolver
hgnc
HGNC:10065
resolver
uniprot
Q5STG3
resolver
uniprot
Q5STG4
resolver
uniprot
Q76BL3
resolver
uniprot
Q8IYT9
resolver
uniprot
Q96IB6
resolver
uniprot_entry
TRI39_HUMAN
resolver
uniprot_sec
Q5STG3
resolver
uniprot_sec
Q5STG4
resolver
uniprot_sec
Q76BL3
resolver
uniprot_sec
Q8IYT9
resolver
uniprot_sec
Q96IB6
resolver
amino_acid_sequence
MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: [Isoform 1]: E3 ubiquitin-protein ligase (PubMed:22529100). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (PubMed:19100260, PubMed:22529100). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251). {ECO:0000269|PubMed:19100260, ECO:0000269|PubMed:22529100, ECO:0000269|PubMed:23213251}.; FUNCTION: [Isoform 2]: Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251). Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner (PubMed:26363554). {ECO:0000269|PubMed:23213251, ECO:0000269|PubMed:26363554}.
uniprot
proteins
mass_dalton
59690
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000269|PubMed:22529100}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11006080
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16702430
uniprot
proteins
pubmed
19100260
uniprot
proteins
pubmed
22529100
uniprot
proteins
pubmed
23213251
uniprot
proteins
pubmed
26363554
uniprot
proteins
sequence_length
518
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:19100260}. Mitochondrion {ECO:0000269|PubMed:19100260}. Nucleus {ECO:0000269|PubMed:23213251}. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus. {ECO:0000269|PubMed:19100260, ECO:0000269|PubMed:23213251}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:23213251}. Note=Colocalizes with CDKN1A in the nucleus. {ECO:0000269|PubMed:23213251}.
uniprot
proteins