Nr2c2
entrez
22026
canonical
uniprot
P49117
canonical
ensembl
ENSMUSG00000005893
resolver
ensp
ENSMUSP00000109087
resolver
ensp
ENSMUSP00000109090
resolver
ensp
ENSMUSP00000305482
resolver
ensp
ENSMUSP00000305485
resolver
ensp
ENSMUSP00000305491
resolver
ensp
ENSMUSP00000305492
resolver
enst
ENSMUST00000113460
resolver
enst
ENSMUST00000113463
resolver
genesymbol
Nr2c2
resolver
genesymbol_syn
Mtr2r1
resolver
genesymbol_syn
Tak1
resolver
genesymbol_syn
Tr4
resolver
uniprot
G3X9W4
resolver
uniprot
P55093
resolver
uniprot
Q3ZAS1
resolver
uniprot_entry
G3X9W4_MOUSE
resolver
uniprot_entry
NR2C2_MOUSE
resolver
uniprot_entry
Q3ZAS1_MOUSE
resolver
uniprot_sec
P55093
resolver
amino_acid_sequence
MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSSKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKADVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSSQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLAADSKAETSQGALGTLANVVTSLANLSESLNNGDASEMQPEDQSASEITRAFDTLAKALNTTDSASPPSLADGIDASGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTGTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL
uniprot
proteins
function
FUNCTION: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Activates transcriptional activity of LHCG and is antagonist of PPARA-mediated transactivation (By similarity). Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior. {ECO:0000250, ECO:0000269|PubMed:12093744, ECO:0000269|PubMed:15199144, ECO:0000269|PubMed:16887930, ECO:0000269|PubMed:17706948, ECO:0000269|PubMed:17974920, ECO:0000269|PubMed:19131575, ECO:0000269|PubMed:20393820}.
uniprot
proteins
mass_dalton
65239
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="S->A: Enhanced transcriptional activation; Greatly enhanced transcriptional activation; when associated with A-68."; MUTAGEN 19; /note="S->E: Some repression of transcriptional activation; Repressed transcriptional activity by about 10-fold; when associated with E-68."; /evidence="ECO:0000269|PubMed:16887930"; MUTAGEN 55; /note="S->A: No effect on transcriptional activation."; /evidence="ECO:0000269|PubMed:16887930"; MUTAGEN 68; /note="S->A: Enhanced transcriptional activation; Greatly enhanced transcriptional activation; when associated with A-15."; /evidence="ECO:0000269|PubMed:16887930"; MUTAGEN 68; /note="S->E: Some repression of transcriptional activation; Repressed transcriptional activity by about 10-fold; when associated with E-19."; /evidence="ECO:0000269|PubMed:16887930
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity. Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas the non-phosphorylated form preferentially recruits the coactivator, PCAF. {ECO:0000269|PubMed:16887930}.
uniprot
proteins
protein_family
NR2 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10347174
uniprot
proteins
pubmed
12093744
uniprot
proteins
pubmed
15199144
uniprot
proteins
pubmed
16887930
uniprot
proteins
pubmed
17706948
uniprot
proteins
pubmed
17974920
uniprot
proteins
pubmed
19131575
uniprot
proteins
pubmed
20393820
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7590273
uniprot
proteins
pubmed
7841789
uniprot
proteins
sequence_length
596
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
uniprot
proteins