Q9ESI7
uniprot
Q9ESI7
canonical
amino_acid_sequence
MELDFGHFDERDKASRNMRGSRMNGLPSPTHSAHCSFYRTRTLQALSNEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLLQGVRYIYTIDGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQSLASSNSAQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSATAGPKASPTPQKTSAKSPGPMRRSKSPADSGNDQDANGTSSSQLSTPKSKQSPISTPTSPGSLRKHKDLYLPLSLDDSDSLGDSM
uniprot
proteins
function
FUNCTION: Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May participate along with PAFAH1B1/LIS-1 in a distinct overlapping signaling pathway that promotes neuronal migration. {ECO:0000269|PubMed:14741102}.
uniprot
proteins
mass_dalton
40560
uniprot
proteins
mutagenesis
MUTAGEN 47; /note="S->A: Impairs phosphorylation by MARK1 and PKA; when associated with A-115."; /evidence="ECO:0000269|PubMed:14741102"; MUTAGEN 115; /note="S->A: Impairs phosphorylation by MARK1 and PKA; when associated with A-47."; /evidence="ECO:0000269|PubMed:14741102
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by MARK1, MARK2 and PKA regulates its ability to bind microtubules (PubMed:14741102). Phosphorylation at Ser-265 and Ser-297 seems to occur only in neonatal brain, the levels falling precipitously by postnatal day 21 (By similarity). {ECO:0000250|UniProtKB:O88809, ECO:0000269|PubMed:14741102}.; PTM: Ubiquitinated by MDM2, leading to its degradation by the proteasome. Ubiquitinated by MDM2 and subsequent degradation leads to reduce the dendritic spine density of olfactory bulb granule cells. {ECO:0000250|UniProtKB:O88809}.
uniprot
proteins
pubmed
14741102
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cell projection, neuron projection {ECO:0000269|PubMed:14741102}. Note=Localizes at neurite tips (PubMed:14741102).
uniprot
proteins