Aldh18a1
entrez
56454
canonical
uniprot
Q9Z110
canonical
ensembl
ENSMUSG00000025007
resolver
ensp
ENSMUSP00000025979
resolver
ensp
ENSMUSP00000135426
resolver
genesymbol
Aldh18a1
resolver
genesymbol_syn
P5cs
resolver
genesymbol_syn
Pycs
resolver
uniprot
Q8BGM2
resolver
uniprot
Q9R1P6
resolver
uniprot_entry
P5CS_MOUSE
resolver
uniprot_sec
Q8BGM2
resolver
uniprot_sec
Q9R1P6
resolver
activity_regulation
ACTIVITY REGULATION: Isoform Short: Inhibited by L-ornithine with a Ki of approximately 0.25 mm. Isoform Long: Insensitive to ornithine inhibition. Thus, the two amino acid insert in the long isoform abolishes feedback inhibition of P5CS activity by L-ornithine. {ECO:0000269|PubMed:10037775}.
uniprot
proteins
amino_acid_sequence
MLRHMHRSGVQPFRQRLLPWVQSIAVPRSNRVQPSAIRHVRSWSNIPFITVPLSRAHGKPFAHRSELKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTSGAVAFGKQRLRHEILLSQSVRQALHSGQNHLKEMAIPVLEARACAAAGQSGLMALYEAMFTQYSICAAQILVTNLDFHDEQKRRNLNGTLHELLRMNIVPIVNTNDAVVPPAEPNSDLQGVNVISVKDNDSLAARLAVEMKTDLLIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSVTFGTKSRVGLGGMEAKVKAALWALQGGTSVVIANGTHPKVSGHVITDIVEGKKVGTFFSEVKPAGPTVEQQGEMARSGGRMLATLEPEQRAEIINHLADLLTDQREEILLANKKDLEEAEGRLASPLLKRLSLSTSKLNSLAIGLRQIAASSQESVGRVLRRTRIAKNLELEQVTVPIGVLLVIFESRPDCLPQVAALAIASGNGLLLKGGKEAAHSNRILHLLTQEALSIHGVKEAIQLVNTREEVEDLCRLDKIIDLIIPRGSSQLVRDIQKAAKGIPVMGHSEGICHMYVDSEASVDKVTRLVRDSKCEYPAACNALETLLIHRDLLRTPLFDQIIDMLRVEQVKIHAGPKFASYLTFSPSEVKSLRTEYGDLEVCIEVVDSVQEAIDHIHKYGSSHTDVIVTENEKTAEFFLQHVDSACVFWNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLTTKWLLRGQDHVVSDFSEHGSLKYLHENLPVPQRNFS
uniprot
proteins
ec_number
1.2.1.41
uniprot
proteins
ec_number
2.7.2.11
uniprot
proteins
function
FUNCTION: Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. {ECO:0000269|PubMed:39506109}.
uniprot
proteins
mass_dalton
87266
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. {ECO:0000250|UniProtKB:P54886}.; PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. {ECO:0000250|UniProtKB:P54886}.
uniprot
proteins
protein_family
Glutamate 5-kinase family; Gamma-glutamyl phosphate reductase family
uniprot
proteins
pubmed
10037775
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
39506109
uniprot
proteins
sequence_length
795
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:39506109}. Note=Exhibits puncta-like structures inside mitochondria under nutrient stress (By similarity). When cellular dependence on oxidative phosphorylation increases, forms filaments, which may increase its activity, and is sequestered in a subset of atypical mitochondria that lack cristae and ATP synthase (PubMed:39506109). {ECO:0000250|UniProtKB:P54886, ECO:0000269|PubMed:39506109}.
uniprot
proteins