CBY3
entrez
646019
canonical
uniprot
A6NI87
canonical
ensembl
ENSG00000204659
resolver
ensembl
ENSG00000283718
resolver
ensp
ENSP00000366173
resolver
ensp
ENSP00000491827
resolver
enst
ENST00000376974
resolver
enst
ENST00000639980
resolver
genesymbol
CBY3
resolver
hgnc
HGNC:33278
resolver
uniprot_entry
CBY3_HUMAN
resolver
amino_acid_sequence
MWASRDHLPEPDLGDAAPPGSPSSFWTSGLPRQERSTSRQRSRGSPSSTCVPYKVHALATFECSATSHASRLWQTLQQFWADHISRPFSPRRPPLRRMPSLSTFYLLDHNTRQAELGLAYGAPCMRLSNQAFVFRGGRWTTESQLARTRSPLLSRTAWGWKAQVQRSKSQVLLEENNYLKLQQELLIDMLTETMARMHLLEKQRNPEVIPTAAARAGQRKMRKRAGASAGVLMIQPCALDSQ
uniprot
proteins
function
FUNCTION: Plays a key role in the correct positioning of the annulus, a septin-based ring structure in the sperm flagellum, serving both as a physical barrier and a membrane diffusion barrier that separates the midpiece (MP) from the principal piece (PP) (By similarity). This positioning is essential for proper sperm motility and function (By similarity). CBY3 interacts with CIBAR1 to form a complex which localizes to the curved membrane region of the flagellar pocket (By similarity). By doing so, may provide stability and rigidity to the periannular membrane to prevent membrane deformation (By similarity). This function is crucial for halting annulus migration at the proximal end of the fibrous sheath-containing PP (By similarity). {ECO:0000250|UniProtKB:Q9CVN6}.
uniprot
proteins
mass_dalton
27343
uniprot
proteins
mutagenesis
MUTAGEN 102; /note="S->A: Reduced interaction with CIBAR1."; /evidence="ECO:0000269|PubMed:38197861"; MUTAGEN 117; /note="G->A: Reduced interaction with CIBAR1."; /evidence="ECO:0000269|PubMed:38197861
uniprot
proteins
protein_family
Chibby family
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
38197861
uniprot
proteins
sequence_length
242
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9CVN6}. Note=Localizes to the annulus at the junction between the midpiece (MP) and principal piece (PP) of the sperm flagellum. {ECO:0000250|UniProtKB:Q9CVN6}.
uniprot
proteins