ANK2
entrez
287
canonical
uniprot
Q01484
canonical
ensembl
ENSG00000145362
resolver
ensp
ENSP00000349588
resolver
ensp
ENSP00000378044
resolver
ensp
ENSP00000421067
resolver
ensp
ENSP00000422888
resolver
ensp
ENSP00000426944
resolver
ensp
ENSP00000499837
resolver
ensp
ENSP00000499869
resolver
ensp
ENSP00000499881
resolver
ensp
ENSP00000499928
resolver
ensp
ENSP00000499943
resolver
ensp
ENSP00000499959
resolver
ensp
ENSP00000499967
resolver
ensp
ENSP00000499979
resolver
ensp
ENSP00000499986
resolver
ensp
ENSP00000499996
resolver
ensp
ENSP00000500007
resolver
ensp
ENSP00000500102
resolver
ensp
ENSP00000500111
resolver
ensp
ENSP00000500112
resolver
ensp
ENSP00000500245
resolver
ensp
ENSP00000500311
resolver
ensp
ENSP00000500378
resolver
ensp
ENSP00000500420
resolver
ensp
ENSP00000500459
resolver
ensp
ENSP00000500473
resolver
ensp
ENSP00000500527
resolver
ensp
ENSP00000500528
resolver
ensp
ENSP00000500544
resolver
ensp
ENSP00000500712
resolver
ensp
ENSP00000500832
resolver
ensp
ENSP00000500833
resolver
ensp
ENSP00000500843
resolver
ensp
ENSP00000500881
resolver
ensp
ENSP00000500908
resolver
ensp
ENSP00000500926
resolver
ensp
ENSP00000500937
resolver
ensp
ENSP00000500954
resolver
ensp
ENSP00000637598
resolver
enst
ENST00000506344
resolver
enst
ENST00000509550
resolver
enst
ENST00000671704
resolver
enst
ENST00000671727
resolver
enst
ENST00000671756
resolver
enst
ENST00000671762
resolver
enst
ENST00000671793
resolver
enst
ENST00000671825
resolver
enst
ENST00000671854
resolver
enst
ENST00000671893
resolver
enst
ENST00000671951
resolver
enst
ENST00000672045
resolver
enst
ENST00000672088
resolver
enst
ENST00000672221
resolver
enst
ENST00000672312
resolver
enst
ENST00000672350
resolver
enst
ENST00000672356
resolver
enst
ENST00000672366
resolver
enst
ENST00000672402
resolver
enst
ENST00000672411
resolver
enst
ENST00000672684
resolver
enst
ENST00000672731
resolver
enst
ENST00000672759
resolver
enst
ENST00000672779
resolver
enst
ENST00000672854
resolver
enst
ENST00000672955
resolver
enst
ENST00000673048
resolver
enst
ENST00000673231
resolver
enst
ENST00000673240
resolver
enst
ENST00000673353
resolver
enst
ENST00000673453
resolver
enst
ENST00000673546
resolver
genesymbol
ANK2
resolver
genesymbol_syn
ANKB
resolver
hgnc
HGNC:493
resolver
uniprot
A0A024RDI4
resolver
uniprot
A0A5F9ZGS5
resolver
uniprot
A0A5F9ZGY1
resolver
uniprot
A0A5F9ZGZ1
resolver
uniprot
A0A5F9ZH03
resolver
uniprot
A0A5F9ZH10
resolver
uniprot
A0A5F9ZH17
resolver
uniprot
A0A5F9ZH18
resolver
uniprot
A0A5F9ZH34
resolver
uniprot
A0A5F9ZH39
resolver
uniprot
A0A5F9ZH58
resolver
uniprot
A0A5F9ZH70
resolver
uniprot
A0A5F9ZH99
resolver
uniprot
A0A5F9ZHE2
resolver
uniprot
A0A5F9ZHJ4
resolver
uniprot
A0A5F9ZHJ6
resolver
uniprot
A0A5F9ZHL3
resolver
uniprot
A0A5F9ZHL9
resolver
uniprot
A0A5F9ZHN0
resolver
uniprot
A0A5F9ZHQ3
resolver
uniprot
A0A5F9ZHR2
resolver
uniprot
A0A5F9ZHY6
resolver
uniprot
A0A5F9ZI08
resolver
uniprot
A0A5F9ZI16
resolver
uniprot
A0A5F9ZI36
resolver
uniprot
A0A5F9ZI53
resolver
uniprot
A0A5F9ZI56
resolver
uniprot
A0A5F9ZI69
resolver
uniprot
A0A5F9ZI81
resolver
uniprot
E9PCH6
resolver
uniprot
H0Y933
resolver
uniprot
Q01485
resolver
uniprot
Q08AC7
resolver
uniprot
Q08AC8
resolver
uniprot
Q7Z3L5
resolver
uniprot_entry
A0A5F9ZGS5_HUMAN
resolver
uniprot_entry
A0A5F9ZGY1_HUMAN
resolver
uniprot_entry
A0A5F9ZGZ1_HUMAN
resolver
uniprot_entry
A0A5F9ZH03_HUMAN
resolver
uniprot_entry
A0A5F9ZH10_HUMAN
resolver
uniprot_entry
A0A5F9ZH17_HUMAN
resolver
uniprot_entry
A0A5F9ZH18_HUMAN
resolver
uniprot_entry
A0A5F9ZH34_HUMAN
resolver
uniprot_entry
A0A5F9ZH39_HUMAN
resolver
uniprot_entry
A0A5F9ZH58_HUMAN
resolver
uniprot_entry
A0A5F9ZH70_HUMAN
resolver
uniprot_entry
A0A5F9ZH99_HUMAN
resolver
uniprot_entry
A0A5F9ZHE2_HUMAN
resolver
uniprot_entry
A0A5F9ZHJ4_HUMAN
resolver
uniprot_entry
A0A5F9ZHJ6_HUMAN
resolver
uniprot_entry
A0A5F9ZHL3_HUMAN
resolver
uniprot_entry
A0A5F9ZHL9_HUMAN
resolver
uniprot_entry
A0A5F9ZHN0_HUMAN
resolver
uniprot_entry
A0A5F9ZHQ3_HUMAN
resolver
uniprot_entry
A0A5F9ZHR2_HUMAN
resolver
uniprot_entry
A0A5F9ZHY6_HUMAN
resolver
uniprot_entry
A0A5F9ZI08_HUMAN
resolver
uniprot_entry
A0A5F9ZI16_HUMAN
resolver
uniprot_entry
A0A5F9ZI36_HUMAN
resolver
uniprot_entry
A0A5F9ZI53_HUMAN
resolver
uniprot_entry
A0A5F9ZI56_HUMAN
resolver
uniprot_entry
A0A5F9ZI69_HUMAN
resolver
uniprot_entry
A0A5F9ZI81_HUMAN
resolver
uniprot_entry
ANK2_HUMAN
resolver
uniprot_entry
E9PCH6_HUMAN
resolver
uniprot_entry
H0Y933_HUMAN
resolver
uniprot_sec
A0A024RDI4
resolver
uniprot_sec
Q01485
resolver
uniprot_sec
Q08AC7
resolver
uniprot_sec
Q08AC8
resolver
uniprot_sec
Q7Z3L5
resolver
amino_acid_sequence
MMNEDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTRDESSVQSSRSERGLVEEEWVIVSDEEIEEARQKAPLEITEYPCVEVRIDKEIKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAVGRSSEKEGKDIPPDETQSTQKQHKPSLGIKKPVRRKLKEKQKQKEEGLQASAEKAELKKGSSEESLGEDPGLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPIRVKGKEDVPKKTTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKTEKHLPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQREAQKTENQTIKRGQRLPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVPEEESHRESEVPKEKMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDKYQQFRLSEETEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALDGSSESLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQTGETKESTKTETTTEIRSEKEHPTTKDITGGSEERGATVTEDSETSTESFQKEATLGSPKDTSPKRQDDCTGSCSVALAKETPTGLTEEAACDEGQRTFGSSAHKTQTDSEVQESTATSDETKALPLPEASVKTDTGTESKPQGVIRSPQGLELALPSRDSEVLSAVADDSLAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKTELLTEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDVSTPKPAVIHECAEEDDSENGEKKRFTPEEEMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHTGSGEDESGVPVLVTSESRKVSSSSESEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMDSNSSPEEVQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRSYDKLNRDTDQPKICDGHGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTHEKDTEGEELDVSRAESPQADCPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTKTDETFENLPKDCPSQDSSITTQTDRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSSEESKTQTDANHTTSFHSSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQESTLWEMQSDSVSSSFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREETLSEDVKEGATGADPLPLETSAESLALSESKETVDDEADLLPDDVSEEVEEIPASDAQLNSQMGISASTETPTKEAVSVGTKDLPTVQTGDIPPLSGVKQISCPDSSEPAVQVQLDFSTLTRSVYSDRGDDSPDSSPEEQKSVIEIPTAPMENVPFTESKSKIPVRTMPTSTPAPPSAEYESSVSEDFLSSVDEENKADEAKPKSKLPVKVPLQRVEQQLSDLDTSVQKTVAPQGQDMASIAPDNRSKSESDASSLDSKTKCPVKTRSYTETETESRERAEELELESEEGATRPKILTSRLPVKSRSTTSSCRGGTSPTKESKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQEIVSDDESSSALEVSVIENLPPVETEHSVPEDIFDTRPIWDESIETLIERIPDENGHDHAEDPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDNNE
uniprot
proteins
disease_involvement
DISEASE: Long QT syndrome 4 (LQT4) [MIM:600919]: A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. Long QT syndrome type 4 shows many atypical features compared to classical long QT syndromes, including pronounced sinus bradycardia, polyphasic T waves and atrial fibrillation. Cardiac repolarization defects may be not as severe as in classical LQT syndromes and prolonged QT interval on EKG is not a consistent feature. {ECO:0000269|PubMed:12571597, ECO:0000269|PubMed:15178757, ECO:0000269|PubMed:17940615}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}.
uniprot
proteins
mass_dalton
433715
uniprot
proteins
mutagenesis
MUTAGEN 975..977; /note="DAR->AAA: Prevents binding to SPTBN1."; /evidence="ECO:0000269|PubMed:15262991"; MUTAGEN 1000; /note="A->P: Prevents binding to SPTBN1."; /evidence="ECO:0000269|PubMed:15262991"; MUTAGEN 1100..1103; /note="ENGD->AAGA: Weak binding to SPTBN1."; /evidence="ECO:0000269|PubMed:15262991
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at multiple sites by different protein kinases and each phosphorylation event regulates the protein's structure and function. {ECO:0000305}.
uniprot
proteins
pubmed
12571597
uniprot
proteins
pubmed
15178757
uniprot
proteins
pubmed
15262991
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15611082
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17940615
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
1830053
uniprot
proteins
pubmed
1833308
uniprot
proteins
pubmed
19007774
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22411828
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27718357
uniprot
proteins
pubmed
8253844
uniprot
proteins
sequence_length
3957
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19007774}. Membrane {ECO:0000269|PubMed:19007774}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q8C8R3}. Apical cell membrane {ECO:0000250|UniProtKB:Q8C8R3}. Cell membrane {ECO:0000269|PubMed:19007774}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q8C8R3}. Early endosome {ECO:0000250|UniProtKB:Q8C8R3}. Recycling endosome {ECO:0000250|UniProtKB:Q8C8R3}. Lysosome {ECO:0000250|UniProtKB:Q8C8R3}. Mitochondrion {ECO:0000250|UniProtKB:Q8C8R3}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q8C8R3}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:Q8C8R3}. Photoreceptor inner segment membrane {ECO:0000269|PubMed:19007774}. Note=Expressed at the apical membrane of airway lung epithelial cells (By similarity). Localized to the plasma membrane of the inner segments of photoreceptors in retina. Colocalizes with SPTBN1 in a distinct intracellular compartment of neonatal cardiomyocytes (PubMed:19007774). In skeletal muscle, localizes to neuromuscular junctions (By similarity). Localizes with puncta at mitochondria ends. Colocalizes and cotransports on motile vesicles with RABGAP1L (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:19007774}.
uniprot
proteins