CDS2
entrez
8760
canonical
uniprot
O95674
canonical
ensembl
ENSG00000101290
resolver
ensp
ENSP00000419879
resolver
ensp
ENSP00000655687
resolver
genesymbol
CDS2
resolver
hgnc
HGNC:1801
resolver
uniprot
B2RDC6
resolver
uniprot
D3DW04
resolver
uniprot
Q5TDY2
resolver
uniprot
Q5TDY3
resolver
uniprot
Q5TDY4
resolver
uniprot
Q5TDY5
resolver
uniprot
Q9BYK5
resolver
uniprot
Q9NTT2
resolver
uniprot_entry
CDS2_HUMAN
resolver
uniprot_sec
B2RDC6
resolver
uniprot_sec
D3DW04
resolver
uniprot_sec
Q5TDY2
resolver
uniprot_sec
Q5TDY3
resolver
uniprot_sec
Q5TDY4
resolver
uniprot_sec
Q5TDY5
resolver
uniprot_sec
Q9BYK5
resolver
uniprot_sec
Q9NTT2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by its anionic phospholipid end products, with phosphatidylinositol-(4,5)- bisphosphate (PIP2) showing the strongest inhibition. Inhibition is also acyl chain specific, with 1-stearoyl-2-arachidonoyl-snphosphatidylinositol showing the strongest inhibition. {ECO:0000269|PubMed:25375833}.
uniprot
proteins
amino_acid_sequence
MTELRQRVAHEPVAPPEDKESESEAKVDGETASDSESRAESAPLPVSADDTPEVLNRALSNLSSRWKNWWVRGILTLAMIAFFFIIIYLGPMVLMIIVMCVQIKCFHEIITIGYNVYHSYDLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRILSKYHRFISFTLYLIGFCMFVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLVIHNLFEGMIWFIVPISCVICNDIMAYMFGFFFGRTPLIKLSPKKTWEGFIGGFFATVVFGLLLSYVMSGYRCFVCPVEYNNDTNSFTVDCEPSDLFRLQEYNIPGVIQSVIGWKTVRMYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVNVYIASFIRGPNPSKLIQQFLTLRPDQQLHIFNTLRSHLIDKGMLTSTTEDE
uniprot
proteins
ec_number
2.7.7.41
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (PubMed:25375833). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). {ECO:0000269|PubMed:25375833, ECO:0000269|PubMed:26946540, ECO:0000269|PubMed:31548309}.
uniprot
proteins
mass_dalton
51418
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
uniprot
proteins
protein_family
CDS family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25375833
uniprot
proteins
pubmed
26946540
uniprot
proteins
pubmed
31548309
uniprot
proteins
pubmed
9806839
uniprot
proteins
pubmed
9889000
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25375833, ECO:0000269|PubMed:26946540, ECO:0000269|PubMed:31548309}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 132..152; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 166..186; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 262..282; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 340..360; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins