Nckap1
entrez
50884
canonical
uniprot
P28660
canonical
ensembl
ENSMUSG00000027002
resolver
ensp
ENSMUSP00000028386
resolver
ensp
ENSMUSP00000107390
resolver
ensp
ENSMUSP00000338486
resolver
enst
ENSMUST00000111760
resolver
genesymbol
Nckap1
resolver
genesymbol_syn
Hem2
resolver
genesymbol_syn
Kiaa0587
resolver
genesymbol_syn
Nap1
resolver
uniprot
A1L0U6
resolver
uniprot
A2AS98
resolver
uniprot
Q3UPY6
resolver
uniprot
Q80TX0
resolver
uniprot
Q8CG49
resolver
uniprot
Q99KY0
resolver
uniprot_entry
A1L0U6_MOUSE
resolver
uniprot_entry
A2AS98_MOUSE
resolver
uniprot_entry
NCKP1_MOUSE
resolver
uniprot_sec
Q3UPY6
resolver
uniprot_sec
Q80TX0
resolver
uniprot_sec
Q8CG49
resolver
uniprot_sec
Q99KY0
resolver
amino_acid_sequence
MSRSVLQPSQQKLAEKLTILNDRGVGMLTRLYNIKKACGDPKAKPSYLIDKNLESAVKFIVRKFPAVETRNNNQQLAQLQKEKSEILKNLALYYFTFVDVMEFKDHVCDLLNTIDVCQVFFDITVNFDLTKNYLDLTVTYTTLMILLSRIEERKAIIGLYNYAHEMTHGASDREYPRLGQMIVDYENPLKKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDTMPCEYLSLDAMEKWIIFGFILCHGMLNTEATALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNKRINDIRECKEAAVSHAGSMHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIWLLRHADNMPKKSADDFIDKHIAELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLSLADHRELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSIAFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMAVWEHTFTPREYLTSHLEIRFTKSIVGMTMYNQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDISEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQMRTSFDKPDQMAALFKRLSSVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSSAAGLPCEIDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTIHKGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIVQESPFLTMDLLESCFPYVLLRNAYHAVYKQSVTSSA
uniprot
proteins
function
FUNCTION: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705). {ECO:0000269|PubMed:14765121, ECO:0000269|PubMed:27605705}.
uniprot
proteins
mass_dalton
128784
uniprot
proteins
protein_family
HEM-1/HEM-2 family
uniprot
proteins
pubmed
12106288
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
14765121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21946561
uniprot
proteins
pubmed
27605705
uniprot
proteins
sequence_length
1128
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14765121}; Single-pass membrane protein {ECO:0000269|PubMed:14765121}; Cytoplasmic side {ECO:0000269|PubMed:14765121}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:14765121}; Single-pass membrane protein {ECO:0000269|PubMed:14765121}; Cytoplasmic side {ECO:0000269|PubMed:14765121}. Cytoplasm {ECO:0000269|PubMed:14765121}. Note=At the interface between the lamellipodial actin meshwork and the membrane.
uniprot
proteins
transmembrane_region
TRANSMEM 995..1015; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins