GRAMD1B
entrez
57476
canonical
uniprot
Q3KR37
canonical
ensembl
ENSG00000023171
resolver
ensp
ENSP00000402457
resolver
ensp
ENSP00000432987
resolver
ensp
ENSP00000436500
resolver
ensp
ENSP00000489896
resolver
ensp
ENSP00000490062
resolver
ensp
ENSP00000490665
resolver
ensp
ENSP00000490920
resolver
ensp
ENSP00000494891
resolver
ensp
ENSP00000613520
resolver
ensp
ENSP00000613521
resolver
ensp
ENSP00000613522
resolver
ensp
ENSP00000724305
resolver
enst
ENST00000533341
resolver
enst
ENST00000635736
resolver
enst
ENST00000638157
resolver
enst
ENST00000646146
resolver
enst
ENST00000943461
resolver
enst
ENST00000943462
resolver
enst
ENST00000943463
resolver
genesymbol
GRAMD1B
resolver
genesymbol_syn
KIAA1201
resolver
hgnc
HGNC:29214
resolver
uniprot
A0A024R3M2
resolver
uniprot
A0A1B0GUD6
resolver
uniprot
A0A1B0GVV0
resolver
uniprot
A0A2R8Y5X2
resolver
uniprot
B3KXJ5
resolver
uniprot
B7Z4N9
resolver
uniprot
E7EPH8
resolver
uniprot
Q6UW85
resolver
uniprot
Q9ULL9
resolver
uniprot_entry
A0A024R3M2_HUMAN
resolver
uniprot_entry
A0A1B0GUD6_HUMAN
resolver
uniprot_entry
A0A1B0GVV0_HUMAN
resolver
uniprot_entry
A0A2R8Y5X2_HUMAN
resolver
uniprot_entry
ASTRB_HUMAN
resolver
uniprot_entry
B7Z4N9_HUMAN
resolver
uniprot_sec
B3KXJ5
resolver
uniprot_sec
E7EPH8
resolver
uniprot_sec
Q6UW85
resolver
uniprot_sec
Q9ULL9
resolver
amino_acid_sequence
MKGFKLSCTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDDDFNTMGYCEEIPVEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFDGLPLEEEALEGDGSLEKELAIDNIMGEKIEMIAPVNSPSLDFNDNEDIPTELSDSSDTHDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKKEENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVARNKSRLRVSTELRYRKQPWGLVKTFIEKNFWSGLEDYFRHLESELAKTESTYLAEMHRQSPKEKASKTTTVRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAGSTQTRHIPEDTPNGFHLQSVSKLLLVISCVICFSLVLLVILNMMLFYKLWMLEYTTQTLTAWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVMLLDQMKDSLINLQNGIRSRDYTSESEEKRNRYH
uniprot
proteins
function
FUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transport from the PM to ER (By similarity). Also mediates cholesterol transfer from lysosomes to endoplasmic reticulum through interaction with NPC1 (PubMed:31537798). {ECO:0000250|UniProtKB:Q80TI0, ECO:0000269|PubMed:31537798}.
uniprot
proteins
mass_dalton
85400
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30220461
uniprot
proteins
pubmed
31537798
uniprot
proteins
sequence_length
738
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30220461, ECO:0000269|PubMed:31537798}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30220461}; Single-pass membrane protein {ECO:0000255}. Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS). {ECO:0000269|PubMed:30220461}.
uniprot
proteins
transmembrane_region
TRANSMEM 623..643; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins