Cyp26c1
entrez
546726
canonical
uniprot
B2RXA7
canonical
ensembl
ENSMUSG00000062432
resolver
ensp
ENSMUSP00000073105
resolver
enst
ENSMUST00000073391
resolver
genesymbol
Cyp26c1
resolver
uniprot_entry
CP26C_MOUSE
resolver
amino_acid_sequence
MISWGLSCLSVLGAAGTTLLCAGLLLGLAQQLWTLRWTLSRDWASTLPLPKGSMGWPFFGETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAVGEPHRQRRKVLARVFSRSSLEQFVPRLQGALRREVRSWCAAQRPVAVYQAAKALTFRMAARILLGLQLDEARCTELAHTFEQLVENLFSLPLDVPFSGLRKGIRARDQLYEHLDEAVAEKLQEKQTAEPGDALLLIINSARELGHEPSVQELKELAVELLFAAFFTTASASTSLILLLLQHPAAITKIQQELSAQGLGRACTCTPRASGSPPDCGCEPDLSLAMLGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGVESGDARGSGGRFHYIPFGGGARSCLGQELAQAVLQLLAVELVRTARWELATPAFPVMQTVPIVHPVDGLLLFFHPLPTSGAGDGLPF
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (Probable) (PubMed:15911617). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the oxidation of atRA primarily at C-4 (Probable). Oxidation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination, thereby contributes to the regulation of atRA homeostasis and signaling. Able to metabolize other RAs such as 9-cis with high efficiency (By similarity). Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (Probable). Shares sequence similarity with other CYP26 family members, but has higher affinity to 9-cis-RA and is much less sensitive to the inhibitory effects of ketoconazole (By similarity). In cooperation with Cyp26a1, contributes to the CNS patterning and the development of regions of higher visual acuity (PubMed:15531370, PubMed:17067568). {ECO:0000250|UniProtKB:Q6V0L0, ECO:0000269|PubMed:15531370, ECO:0000269|PubMed:15911617, ECO:0000269|PubMed:17067568, ECO:0000305|PubMed:12915310, ECO:0000305|PubMed:15531370, ECO:0000305|PubMed:15872003, ECO:0000305|PubMed:15911617}.
uniprot
proteins
mass_dalton
57026
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
12915310
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15531370
uniprot
proteins
pubmed
15872003
uniprot
proteins
pubmed
15911617
uniprot
proteins
pubmed
17067568
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
518
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins