Il22
entrez
50929
canonical
uniprot
Q9JJY9
canonical
ensembl
ENSMUSG00000074695
resolver
ensp
ENSMUSP00000094449
resolver
enst
ENSMUST00000096691
resolver
genesymbol
Il22
resolver
genesymbol_syn
Il22a
resolver
genesymbol_syn
Iltif
resolver
genesymbol_syn
Iltifa
resolver
uniprot
Q14BB3
resolver
uniprot_entry
IL22_MOUSE
resolver
uniprot_sec
Q14BB3
resolver
amino_acid_sequence
MAVLQKSMSFSLMGTLAASCLLLIALWAQEANALPVNTRCKLEVSNFQQPYIVNRTFMLAKEASLADNNTDVRLIGEKLFRGVSAKDQCYLMKQVLNFTLEDVLLPQSDRFQPYMQEVVPFLTKLSNQLSSCHISGDDQNIQKNVRRLKETVKKLGESGEIKAIGELDLLFMSLRNACV
uniprot
proteins
function
FUNCTION: Cytokine that plays a critical role in modulating tissue responses during inflammation (PubMed:33852830, PubMed:35525330). Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage (PubMed:33912578). Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB. Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways. Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN (PubMed:24742671). Promotes epithelial cell spreading (PubMed:24742671). {ECO:0000250|UniProtKB:Q9GZX6, ECO:0000269|PubMed:24742671, ECO:0000269|PubMed:33852830, ECO:0000269|PubMed:33912578, ECO:0000269|PubMed:35525330}.
uniprot
proteins
mass_dalton
20106
uniprot
proteins
protein_family
IL-10 family
uniprot
proteins
pubmed
10657629
uniprot
proteins
pubmed
11197690
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24742671
uniprot
proteins
pubmed
33852830
uniprot
proteins
pubmed
33912578
uniprot
proteins
pubmed
35525330
uniprot
proteins
sequence_length
179
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins