DPY19L3
entrez
147991
canonical
uniprot
Q6ZPD9
canonical
ensembl
ENSG00000178904
resolver
ensp
ENSP00000344937
resolver
ensp
ENSP00000376081
resolver
ensp
ENSP00000522782
resolver
ensp
ENSP00000522783
resolver
ensp
ENSP00000717425
resolver
genesymbol
DPY19L3
resolver
hgnc
HGNC:27120
resolver
uniprot
Q68DC7
resolver
uniprot
Q6ZTB7
resolver
uniprot
Q6ZTS2
resolver
uniprot_entry
D19L3_HUMAN
resolver
uniprot_sec
Q68DC7
resolver
uniprot_sec
Q6ZTB7
resolver
uniprot_sec
Q6ZTS2
resolver
amino_acid_sequence
MMSIRQRREIRATEVSEDFPAQEENVKLENKLPSGCTSRRLWKILSLTIGGTIALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLVQGFHGLIYDNKTESMKTINLLQRMNIYQEVFLSILYRVLPIQKYLEPVYFYIYTLFGLQAIYVTALYITSWLLSGTWLSGLLAAFWYVTNRIDTTRVEFTIPLRENWALPFFAIQIAAITYFLRPNLQPLSERLTLLAIFISTFLFSLTWQFNQFMMLMQALVLFTLDSLDMLPAVKATWLYGIQITSLLLVCILQFFNSMILGSLLISFNLSVFIARKLQKNLKTGSFLNRLGKLLLHLFMVLCLTLFLNNIIKKILNLKSDEHIFKFLKAKFGLGATRDFDANLYLCEEAFGLLPFNTFGRLSDTLLFYAYIFVLSITVIVAFVVAFHNLSDSTNQQSVGKMEKGTVDLKPETAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGLCSPEIWELLLKSVHLYNPKRICIMRYSVPILILLYLCYKFWPGMMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDSSLRERTRAVYQIYAKRAPEEVHALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHMMDGPGENDPDLKPADHPRFCEEIKRNLPPYVAYFTRVFQNKTFHVYKLSRNK
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
function
FUNCTION: C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. The reaction occurs on the luminal side of the endoplasmic reticulum and involves the transfer of a mannose unit from a dolichylphosphate mannose (Dol-P-Man) donor to an acceptor protein containing a WxxW or WxxC consensus sequence (PubMed:26764097, PubMed:29405629). C-mannosylates RSPO1, a Wnt signaling regulator, preferentially at the first Trp residue in the sequence WxxW (PubMed:26764097, PubMed:29405629). C-mannosylates the netrin receptor UNC5A, preferentially at the third tryptophan of WxxWxxWxxC sequence (By similarity). {ECO:0000250|UniProtKB:Q71B07, ECO:0000269|PubMed:26764097, ECO:0000269|PubMed:29405629}.; FUNCTION: [Isoform 2]: Has no C-mannosyltransferase activity. {ECO:0000269|PubMed:29405629}.
uniprot
proteins
mass_dalton
83197
uniprot
proteins
mutagenesis
MUTAGEN 118; /note="N->Q: Does not affect endoplasmic reticulum membrane localization. Does not affect mannosyltransferase activity."; /evidence="ECO:0000269|PubMed:29405629"; MUTAGEN 704; /note="N->Q: Does not affect endoplasmic reticulum membrane localization. Does not affect mannosyltransferase activity."; /evidence="ECO:0000269|PubMed:29405629
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:26764097, ECO:0000269|PubMed:29405629}.
uniprot
proteins
protein_family
Dpy-19 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16526957
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
26764097
uniprot
proteins
pubmed
29405629
uniprot
proteins
sequence_length
716
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29405629}; Multi-pass membrane protein {ECO:0000269|PubMed:29405629}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29405629}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..64; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 155..182; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 240..256; /note="Helical; Name=5"; /evidence="ECO:0000303|PubMed:29405629"; TRANSMEM 263..279; /note="Helical; Name=6"; /evidence="ECO:0000303|PubMed:29405629"; TRANSMEM 290..306; /note="Helical; Name=7"; /evidence="ECO:0000303|PubMed:29405629"; TRANSMEM 309..323; /note="Helical; Name=8"; /evidence="ECO:0000303|PubMed:29405629"; TRANSMEM 339..359; /note="Helical; Name=9"; /evidence="ECO:0000303|PubMed:29405629"; TRANSMEM 415..437; /note="Helical; Name=10"; /evidence="ECO:0000303|PubMed:29405629"; TRANSMEM 466..485; /note="Helical; Name=11"; /evidence="ECO:0000303|PubMed:29405629"; TRANSMEM 488..499; /note="Helical; Name=12"; /evidence="ECO:0000303|PubMed:29405629"; TRANSMEM 523..539; /note="Helical; Name=13"; /evidence="ECO:0000303|PubMed:29405629
uniprot
proteins