NDEL1
entrez
81565
canonical
uniprot
Q9GZM8
canonical
ensembl
ENSG00000166579
resolver
ensp
ENSP00000333982
resolver
ensp
ENSP00000369364
resolver
ensp
ENSP00000384963
resolver
ensp
ENSP00000522298
resolver
ensp
ENSP00000789971
resolver
enst
ENST00000380025
resolver
genesymbol
NDEL1
resolver
genesymbol_syn
EOPA
resolver
genesymbol_syn
MITAP1
resolver
genesymbol_syn
NUDEL
resolver
hgnc
HGNC:17620
resolver
uniprot
A6NIZ0
resolver
uniprot
B3KP93
resolver
uniprot
D3DTS0
resolver
uniprot
J3QT32
resolver
uniprot
Q86T80
resolver
uniprot
Q8TAR7
resolver
uniprot
Q9UH50
resolver
uniprot_entry
A6NIZ0_HUMAN
resolver
uniprot_entry
NDEL1_HUMAN
resolver
uniprot_sec
B3KP93
resolver
uniprot_sec
D3DTS0
resolver
uniprot_sec
J3QT32
resolver
uniprot_sec
Q86T80
resolver
uniprot_sec
Q8TAR7
resolver
uniprot_sec
Q9UH50
resolver
amino_acid_sequence
MDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTFPSPKAIPNGFGTSPLTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYISGNVNCGVLNGNGTKFSRSGHTSFFDKGAVNGFDPAPPPPGLGSSRPSSAPGMLPLSV
uniprot
proteins
function
FUNCTION: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000250|UniProtKB:Q78PB6, ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:34793709}.
uniprot
proteins
mass_dalton
38375
uniprot
proteins
mutagenesis
MUTAGEN 198; /note="S->A: Abrogates mitotic phosphorylation; when associated with V-219; A-231; A-242 and V-245. Abrogates phosphorylation by CDK5; when associated with A-219 and A-231."; /evidence="ECO:0000269|PubMed:11163260, ECO:0000269|PubMed:12556484"; MUTAGEN 198; /note="S->E: Enhances interaction with PAFAH1B1 and impairs centrosomal localization; when associated with E-219; E-231; E-242 and E-245."; /evidence="ECO:0000269|PubMed:11163260, ECO:0000269|PubMed:12556484"; MUTAGEN 219; /note="T->A: Abrogates phosphorylation by CDK5; when associated with A-198 and A-231."; /evidence="ECO:0000269|PubMed:11163260, ECO:0000269|PubMed:12556484"; MUTAGEN 219; /note="T->E: Enhances interaction with PAFAH1B1 and impairs centrosomal localization; when associated with E-198; E-231; E-242 and E-245."; /evidence="ECO:0000269|PubMed:11163260, ECO:0000269|PubMed:12556484"; MUTAGEN 219; /note="T->V: Abrogates mitotic phosphorylation; when associated with A-198; A-231; A-242 and V-245."; /evidence="ECO:0000269|PubMed:11163260, ECO:0000269|PubMed:12556484"; MUTAGEN 231; /note="S->A: Abrogates mitotic phosphorylation; when associated with A-198; V-219; A-242 and V-245. Abrogates phosphorylation by CDK5; when associated with A-198 and A-219."; /evidence="ECO:0000269|PubMed:11163260, ECO:0000269|PubMed:12556484"; MUTAGEN 231; /note="S->E: Enhances interaction with PAFAH1B1 and impairs centrosomal localization; when associated with E-198; E-219; E-242 and E-245."; /evidence="ECO:0000269|PubMed:11163260, ECO:0000269|PubMed:12556484"; MUTAGEN 242; /note="S->A: Abrogates mitotic phosphorylation; when associated with A-198; V-219; A-231 and V-245."; /evidence="ECO:0000269|PubMed:12556484"; MUTAGEN 242; /note="S->E: Enhances interaction with PAFAH1B1 and impairs centrosomal localization; when associated with E-198; E-219; E-231 and E-245."; /evidence="ECO:0000269|PubMed:12556484"; MUTAGEN 245; /note="T->E: Enhances interaction with PAFAH1B1 and impairs centrosomal localization; when associated with E-198; E-219; E-231 and E-242."; /evidence="ECO:0000269|PubMed:12556484"; MUTAGEN 245; /note="T->V: Abrogates mitotic phosphorylation; when associated with A-198; V-219; A-231 and A-242."; /evidence="ECO:0000269|PubMed:12556484"; MUTAGEN 266; /note="L->A: Abolishes interaction with DISC1; when associated with A-267."; /evidence="ECO:0000269|PubMed:17035248"; MUTAGEN 267; /note="E->A: Abolishes interaction with DISC1; when associated with A-266."; /evidence="ECO:0000269|PubMed:17035248"; MUTAGEN 273; /note="C->A: Abolishes oligopeptidase activity."; /evidence="ECO:0000269|PubMed:15728732
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE. {ECO:0000269|PubMed:11163260, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:16203747}.; PTM: Palmitoylation at Cys-273 reduces affinity for dynein. {ECO:0000269|PubMed:19927128}.
uniprot
proteins
protein_family
NudE family
uniprot
proteins
pubmed
11163260
uniprot
proteins
pubmed
12506198
uniprot
proteins
pubmed
12556484
uniprot
proteins
pubmed
12812986
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14962739
uniprot
proteins
pubmed
14970193
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15572112
uniprot
proteins
pubmed
15728732
uniprot
proteins
pubmed
16005531
uniprot
proteins
pubmed
16203747
uniprot
proteins
pubmed
16291865
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16682949
uniprot
proteins
pubmed
17035248
uniprot
proteins
pubmed
17600710
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19927128
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
34793709
uniprot
proteins
sequence_length
345
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner. {ECO:0000250}.
uniprot
proteins