Bhlhe40
entrez
20893
canonical
uniprot
O35185
canonical
ensembl
ENSMUSG00000030103
resolver
ensp
ENSMUSP00000032194
resolver
enst
ENSMUST00000032194
resolver
genesymbol
Bhlhe40
resolver
genesymbol_syn
Bhlhb2
resolver
genesymbol_syn
Clast5
resolver
genesymbol_syn
Dec1
resolver
genesymbol_syn
Stra13
resolver
uniprot
P97289
resolver
uniprot
Q542A5
resolver
uniprot_entry
BHE40_MOUSE
resolver
uniprot_entry
Q542A5_MOUSE
resolver
uniprot_sec
P97289
resolver
amino_acid_sequence
MERIPSAQPPPTCLPKAPGLEHGDLSGMDFAHMYQVYKSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGDLSGRNLEAGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGASRKPLDSAPKAVDLKEKPSFLAKGSEGPGKNCVPVIQRTFAPSGGEQSGSDTDTDSGYGGELEKGDLRSEQPYFKSDHGRRFAVGERVSTIKQESEEPPTKKSRMQLSEEEGHFAGSDLMGSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNTSAAALSSFMNPDKIPTPLLLPQRLPSPLAHSSLDSSALLQALKQIPPLNLETKD
uniprot
proteins
function
FUNCTION: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:18411297). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop) (PubMed:14672706). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2 (By similarity). Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1|BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (By similarity). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2 (PubMed:14672706). Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity (PubMed:19786558). May function as a transcriptional factor for neuronal differentiation (PubMed:9284045). Represses the transcription of NR0B2 and attenuates the transactivation of NR0B2 by the CLOCK-BMAL1 complex (By similarity). Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (PubMed:30012868). {ECO:0000250|UniProtKB:O14503, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:18411297, ECO:0000269|PubMed:19786558, ECO:0000269|PubMed:30012868, ECO:0000269|PubMed:9284045}.
uniprot
proteins
mass_dalton
45361
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; which may lead to proteasomal degradation. {ECO:0000250}.; PTM: Sumoylation inhibits its ubiquitination and promotes its negative regulation of the CLOCK-BMAL1 heterodimer transcriptional activator activity. {ECO:0000250}.
uniprot
proteins
pubmed
14672706
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15560782
uniprot
proteins
pubmed
18411297
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19786558
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30012868
uniprot
proteins
pubmed
9050988
uniprot
proteins
pubmed
9284045
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O14503}. Nucleus {ECO:0000250|UniProtKB:O14503}. Note=Predominantly localized in the nucleus (By similarity). {ECO:0000250|UniProtKB:O14503}.
uniprot
proteins