Comt
entrez
24267
canonical
uniprot
P22734
canonical
ensembl
ENSRNOG00000001889
resolver
ensembl
ENSRNOG00055003518
resolver
ensembl
ENSRNOG00060012669
resolver
ensembl
ENSRNOG00065008231
resolver
ensp
ENSRNOP00000086073
resolver
ensp
ENSRNOP00000092582
resolver
enst
ENSRNOT00000119057
resolver
genesymbol
Comt
resolver
uniprot
A0A8I6A1I0
resolver
uniprot
F2W8B0
resolver
uniprot
F2W8B1
resolver
uniprot_entry
A0A8I6A1I0_RAT
resolver
uniprot_entry
COMT_RAT
resolver
uniprot_entry
F2W8B0_RAT
resolver
uniprot_entry
F2W8B1_RAT
resolver
amino_acid_sequence
MPLAAVSLGLLLLALLLLLRHLGWGLVTIFWFEYVLQPVHNLIMGDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSSPDKS
uniprot
proteins
ec_number
2.1.1.6
uniprot
proteins
function
FUNCTION: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. {ECO:0000269|PubMed:12237326, ECO:0000269|PubMed:16618795}.
uniprot
proteins
mass_dalton
29597
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.
uniprot
proteins
protein_family
Cation-dependent O-methyltransferase family
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
10785817
uniprot
proteins
pubmed
12237326
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16618795
uniprot
proteins
pubmed
1765063
uniprot
proteins
pubmed
2227437
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8127373
uniprot
proteins
pubmed
8280056
uniprot
proteins
sequence_length
264
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Soluble]: Cytoplasm {ECO:0000269|PubMed:1765063}.; SUBCELLULAR LOCATION: [Isoform Membrane-bound]: Cell membrane {ECO:0000269|PubMed:1765063}; Single-pass type II membrane protein {ECO:0000255}; Extracellular side {ECO:0000305|PubMed:1765063}.
uniprot
proteins
transmembrane_region
TRANSMEM 3..19; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins