Pacc1
entrez
305070
canonical
uniprot
Q66H28
canonical
ensembl
ENSRNOG00000003915
resolver
ensembl
ENSRNOG00055011255
resolver
ensembl
ENSRNOG00060013734
resolver
ensembl
ENSRNOG00065004004
resolver
ensp
ENSRNOP00000005387
resolver
ensp
ENSRNOP00055015361
resolver
ensp
ENSRNOP00060018599
resolver
ensp
ENSRNOP00065004210
resolver
enst
ENSRNOT00000005387
resolver
enst
ENSRNOT00055019072
resolver
enst
ENSRNOT00060023442
resolver
enst
ENSRNOT00065005855
resolver
genesymbol
Pacc1
resolver
genesymbol_syn
Tmem206
resolver
uniprot_entry
PACC1_RAT
resolver
amino_acid_sequence
MIRQDLSTSYQELSEELEQVVENSEQADERDKELVQVQGPGVVPGVDNESASSSIRFSKACLKNVFSVLLILIYLLLMAVAVFLVYQTITDFREKLKHPVMSVSYKEVDRYDAPGIALYPGQAQLLSCKHHYEVIPPLASPGQPGDRNCTTQRINYTHPFSNHTMQSALIVQGPQEVKKRELVFLQFRLNQSDEDFSAIDYLLFSSFREFMQSPDKAGFMQACESAYSSWKFSGGFRTWVKMSLVKTKEEDGREAVEFRQETSVVNYIDQRPAAEKSTQLFFVVFEWKDPFIQKVQDIITANPWNTIALLCGAFLALFKAAEFAKLSVKWMIKIRKRYLKRRGQATNHIS
uniprot
proteins
function
FUNCTION: Chloride channel gated by pH that facilitates the entry of chloride ions into cells upon exposure to extracellular acidic pH. Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling. {ECO:0000250|UniProtKB:Q9H813}.
uniprot
proteins
mass_dalton
40073
uniprot
proteins
protein_family
Proton-activated chloride channel family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H813}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H813}.
uniprot
proteins
transmembrane_region
TRANSMEM 65..85; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 302..318; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins