SEPT6
entrez
23157
canonical
uniprot
Q14141
canonical
ensembl
ENSG00000125354
resolver
ensp
ENSP00000341524
resolver
ensp
ENSP00000346169
resolver
ensp
ENSP00000346397
resolver
ensp
ENSP00000353278
resolver
ensp
ENSP00000378108
resolver
ensp
ENSP00000747728
resolver
ensp
ENSP00000747731
resolver
enst
ENST00000354416
resolver
genesymbol
SEPT6
resolver
genesymbol
SEPTIN6
resolver
genesymbol_syn
KIAA0128
resolver
genesymbol_syn
SEP2
resolver
genesymbol_syn
SEPT6
resolver
hgnc
HGNC:15848
resolver
uniprot
B1AMS2
resolver
uniprot
Q541S4
resolver
uniprot
Q548C9
resolver
uniprot
Q5JTK0
resolver
uniprot
Q969W5
resolver
uniprot
Q96A13
resolver
uniprot
Q96GR1
resolver
uniprot
Q96P86
resolver
uniprot
Q96P87
resolver
uniprot_entry
B1AMS2_HUMAN
resolver
uniprot_entry
Q541S4_HUMAN
resolver
uniprot_entry
Q548C9_HUMAN
resolver
uniprot_entry
SEPT6_HUMAN
resolver
uniprot_sec
Q5JTK0
resolver
uniprot_sec
Q969W5
resolver
uniprot_sec
Q96A13
resolver
uniprot_sec
Q96GR1
resolver
uniprot_sec
Q96P86
resolver
uniprot_sec
Q96P87
resolver
amino_acid_sequence
MAATDIARQVGEGCRTVPLAGHVGFDSLPDQLVNKSVSQGFCFNILCVGETGLGKSTLMDTLFNTKFEGEPATHTQPGVQLQSNTYDLQESNVRLKLTIVSTVGFGDQINKEDSYKPIVEFIDAQFEAYLQEELKIRRVLHTYHDSRIHVCLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADAISKSELTKFKIKITSELVSNGVQIYQFPTDDESVAEINGTMNAHLPFAVIGSTEELKIGNKMMRARQYPWGTVQVENEAHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVQRVKEKEAELKEAEKELHEKFDRLKKLHQDEKKKLEDKKKSLDDEVNAFKQRKTAAELLQSQGSQAGGSQTLKRDKEKKNNPWLCTE
uniprot
proteins
function
FUNCTION: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17229681, ECO:0000269|PubMed:17803907, ECO:0000305|PubMed:25588830}.
uniprot
proteins
mass_dalton
49717
uniprot
proteins
protein_family
Septin GTPase family
uniprot
proteins
protein_family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily
uniprot
proteins
pubmed
11809673
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
15774761
uniprot
proteins
pubmed
15915442
uniprot
proteins
pubmed
16093351
uniprot
proteins
pubmed
16914550
uniprot
proteins
pubmed
17229681
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17637674
uniprot
proteins
pubmed
17803907
uniprot
proteins
pubmed
18047794
uniprot
proteins
pubmed
19145258
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25588830
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28346465
uniprot
proteins
pubmed
8590280
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15774761}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15774761}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15774761}. Cleavage furrow {ECO:0000269|PubMed:15774761}. Midbody {ECO:0000269|PubMed:15774761}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:25588830}. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. Expressed in the sperm annulus and head (PubMed:25588830). {ECO:0000269|PubMed:25588830}.
uniprot
proteins