Calcrl
entrez
25029
canonical
uniprot
Q63118
canonical
ensembl
ENSRNOG00000054695
resolver
ensembl
ENSRNOG00055021800
resolver
ensembl
ENSRNOG00060010321
resolver
ensembl
ENSRNOG00065021521
resolver
ensp
ENSRNOP00000074452
resolver
ensp
ENSRNOP00055030502
resolver
ensp
ENSRNOP00060013601
resolver
ensp
ENSRNOP00065029528
resolver
enst
ENSRNOT00000078645
resolver
enst
ENSRNOT00055037418
resolver
enst
ENSRNOT00060017511
resolver
enst
ENSRNOT00065036689
resolver
genesymbol
Calcrl
resolver
genesymbol_syn
Cgrpr
resolver
uniprot_entry
CALRL_RAT
resolver
amino_acid_sequence
MMDKKCTLCFLFLLLLNMALIAAESEEGANQTDLGVTRNKIMTAQYECYQKIMQDPIQQGEGLYCNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTKICDQDGNWFRHPDSNRTWTNYTLCNNSTHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNLFFSFVCNSIVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLLPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLFPWRPEGKVAEEVYDYVMHILMHYQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNGFSHSDALRSASYTVSTISDVQGYSHDCPTEHLNGKSIQDIENVALKPEKMYDLVM
uniprot
proteins
function
FUNCTION: G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. {ECO:0000250|UniProtKB:Q16602}.
uniprot
proteins
mass_dalton
53329
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
8222502
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q16602}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16602}.
uniprot
proteins
transmembrane_region
TRANSMEM 140..164; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q16602"; TRANSMEM 176..198; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q16602"; TRANSMEM 210..238; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q16602"; TRANSMEM 253..273; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q16602"; TRANSMEM 290..314; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q16602"; TRANSMEM 330..351; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q16602"; TRANSMEM 367..387; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q16602
uniprot
proteins