Spidr
entrez
224008
canonical
uniprot
Q8BGX7
canonical
ensembl
ENSMUSG00000041974
resolver
ensp
ENSMUSP00000038820
resolver
ensp
ENSMUSP00000344827
resolver
genesymbol
Spidr
resolver
genesymbol_syn
Kiaa0146
resolver
uniprot
Q3TCD0
resolver
uniprot
Q5U457
resolver
uniprot
Q6A0B6
resolver
uniprot
Q6IS60
resolver
uniprot
Q811E1
resolver
uniprot
Q8BWD6
resolver
uniprot
Q8R305
resolver
uniprot_entry
SPIDR_MOUSE
resolver
uniprot_sec
Q3TCD0
resolver
uniprot_sec
Q5U457
resolver
uniprot_sec
Q6A0B6
resolver
uniprot_sec
Q6IS60
resolver
uniprot_sec
Q811E1
resolver
uniprot_sec
Q8BWD6
resolver
uniprot_sec
Q8R305
resolver
amino_acid_sequence
MSGARRPGTSKRKRNWHIEHPSFREERSQQLRRGNFKTVEAADSLSKAWLKCGEGFQDTSEILSLASEKTGITEKHLELSPKPKTETTSKNASELPNIIWSSSESDFSDEDKTLPALQRDGRHGPRADRLGDRTISCPEDEDIEDELQVIDWEVNSDKEDPGGPSECEDDKGTLDISDCDSCASLTSDDRLCEPSEPISTEILEYSSDSEKEEDPEHSLFIDSESPHKYQADFKSDARWCLVSQTDSEANSAEPTLTPQKYTVKFPKTPEYSVTKKKLLRGGLAERLQELQNRKRSAISLWRHRCVSYQMTPLGRKSGVLTVKILELHEECSMQVAVCEQLAGPPITSPPGGLAPRPGAYLKVLFTRETADHLMGHPQDIIYIFPPWQKLLIPNGSCSIILNTYFCQKAIAKETVREDLYSPDISLSRRNITLAQTFRIKDITDNSSINQTTYDSLATPGTGWTHGHEKAEQHLIVAAPLRNSLLDIVESQRAGLWSGVRVQVVVQRVYSLLSRDGARSQQGHTVGHADASGAWSCLLVQDACGMFGEVFLNSTLWKSRQLEGKSCSMSGVKVLQKATRGRTPGLFSLIDSLWPPVISLTEPSCGQPSGETKTYLPPPIFCYIFSAHPTLGQIDAIEDHISKLYQPPVVRCLKEILQTNECSTRCSFYARVIYQKPQLKNLLAQKEIWLLVTDITLQTQDERDHSLPKTLPVYIAPSCVLGPEVVEELALLVSYNLLFRDAFKDNGQIVCIERTVILPQKPLLCVPSASCDLPSPVTLDELSALTPVNSICSVQGTVVDVDESTAFSWPVCDRCGNGRLEQKPEDGGTFSCGDCSQLVLSPLQERHLHVFLDCPTRPESTVKVKLLESSISLLLMSAASEDGSYEVESVLGKEMGPLLCFVQSITTQQSSCVVTLEEIELLSTEGATAAQPPP
uniprot
proteins
function
FUNCTION: Involved in early stages DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:34253720). As part of the Shu complex, promotes HR by regulating replication protein-A (RPA) dynamics on single-stranded DNA, thereby stabilizing RAD51 and DMC1 filaments on DNA (PubMed:34253720). The Shu complex is essential during meiosis by stabilizing DMC1 filaments (PubMed:34253720, PubMed:36938872). In contrast, it is critical for only certain types of homologous-directed DNA repair, such as inter-homolog homologous recombination (IR-HR) (PubMed:34253720). IR-HR is a DNA repair mechanism where a cell repairs a DSB on one chromosome using the matching homologous chromosome as a template, rather than the sister chromatid (PubMed:34253720). {ECO:0000269|PubMed:34253720, ECO:0000269|PubMed:36938872}.
uniprot
proteins
mass_dalton
103297
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
34253720
uniprot
proteins
pubmed
36938872
uniprot
proteins
sequence_length
933
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q14159}. Nucleus {ECO:0000250|UniProtKB:Q14159}. Note=Together with BLM, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. {ECO:0000250|UniProtKB:Q14159}.
uniprot
proteins