PRSS57
entrez
400668
canonical
uniprot
Q6UWY2
canonical
ensembl
ENSG00000185198
resolver
ensp
ENSP00000327386
resolver
ensp
ENSP00000482358
resolver
enst
ENST00000329267
resolver
enst
ENST00000613411
resolver
genesymbol
PRSS57
resolver
genesymbol
PRSSL1
resolver
genesymbol_syn
PRSSL1
resolver
hgnc
HGNC:31397
resolver
uniprot
A0A0A0MR61
resolver
uniprot
B2RNW8
resolver
uniprot
B7ZMF6
resolver
uniprot_entry
A0A0A0MR61_HUMAN
resolver
uniprot_entry
B7ZMF6_HUMAN
resolver
uniprot_entry
PRS57_HUMAN
resolver
uniprot_sec
B2RNW8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by SERPINA1, SERPINC1 and SERPING1. {ECO:0000269|PubMed:22474388}.
uniprot
proteins
amino_acid_sequence
MGLGLRGWGRPLLTVATALMLPVKPPAGSWGAQIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLGPAVGLLRPPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPDVCNSSWKGHLTLTMLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVVRRSSPQPGPLPGTTRPPGEAA
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine protease that cleaves preferentially after Arg residues (PubMed:22474388, PubMed:23904161, PubMed:25156428). Can also cleave after citrulline (deimidated arginine) and methylarginine residues (PubMed:25156428). {ECO:0000269|PubMed:22474388, ECO:0000269|PubMed:23904161, ECO:0000269|PubMed:25156428}.
uniprot
proteins
mass_dalton
30334
uniprot
proteins
mutagenesis
MUTAGEN 213; /note="F->A: Decreases enzyme activity tenfold."; /evidence="ECO:0000269|PubMed:25156428"; MUTAGEN 215; /note="S->A: Decreases enzyme activity tenfold. Decreases enzyme activity twentyfold; when associated with G-236."; /evidence="ECO:0000269|PubMed:25156428"; MUTAGEN 235; /note="S->G: Decreases enzyme activity tenfold. Decreases enzyme activity twentyfold; when associated with A-215."; /evidence="ECO:0000269|PubMed:25156428
uniprot
proteins
post_translational_modification
PTM: After cleavage of the signal peptide, the N-terminus is probably further processed by CTSC (PubMed:22474388, PubMed:23904161). Processing by CTSC is probably required for accumulation in cytoplasmic granules; in the absence of CTSC the protein does not accumulate (PubMed:23904161). {ECO:0000269|PubMed:23904161, ECO:0000305|PubMed:22474388}.; PTM: N-glycosylated. {ECO:0000269|PubMed:23904161}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22474388
uniprot
proteins
pubmed
23904161
uniprot
proteins
pubmed
25156428
uniprot
proteins
sequence_length
283
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic granule lumen {ECO:0000269|PubMed:22474388, ECO:0000269|PubMed:23904161}. Secreted {ECO:0000269|PubMed:22474388, ECO:0000269|PubMed:23904161}. Note=Stored in cytoplasmic granules and secreted as active enzyme in response to stimulation of neutrophils. {ECO:0000269|PubMed:22474388}.
uniprot
proteins