SAFB
entrez
6294
canonical
uniprot
Q15424
canonical
ensembl
ENSG00000160633
resolver
ensp
ENSP00000292123
resolver
ensp
ENSP00000415895
resolver
ensp
ENSP00000464840
resolver
ensp
ENSP00000467423
resolver
ensp
ENSP00000550752
resolver
genesymbol
SAFB
resolver
genesymbol_syn
HAP
resolver
genesymbol_syn
HET
resolver
genesymbol_syn
SAFB1
resolver
hgnc
HGNC:10520
resolver
uniprot
A0AV56
resolver
uniprot
B7Z2F6
resolver
uniprot
B7Z5B6
resolver
uniprot
B7ZLP5
resolver
uniprot
B7ZLP6
resolver
uniprot
F5H0H3
resolver
uniprot
O60406
resolver
uniprot
Q59HH8
resolver
uniprot_entry
B7Z2F6_HUMAN
resolver
uniprot_entry
B7ZLP5_HUMAN
resolver
uniprot_entry
SAFB1_HUMAN
resolver
uniprot_sec
A0AV56
resolver
uniprot_sec
B7Z5B6
resolver
uniprot_sec
B7ZLP6
resolver
uniprot_sec
F5H0H3
resolver
uniprot_sec
O60406
resolver
uniprot_sec
Q59HH8
resolver
amino_acid_sequence
MAETLSGLGDSGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSSGNKSVLMERLKKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRRDWGDHGRREDDRSWQGTADGGMMDRDHKRWQGGERSMSGHSGPGHMMNRGGMSGRGSFAPGGASRGHPIPHGGMQGGFGGQSRGSRPSDARFTRRY
uniprot
proteins
function
FUNCTION: Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}.
uniprot
proteins
mass_dalton
102642
uniprot
proteins
post_translational_modification
PTM: Sumoylated by PIAS1 with SUMO1 and SUMO2/3, desumoylated by SENP1. Sumoylation is required for transcriptional repressor activity. {ECO:0000269|PubMed:21527249}.
uniprot
proteins
pubmed
11509566
uniprot
proteins
pubmed
12660241
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19674106
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21527249
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22693546
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27731383
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
8600450
uniprot
proteins
pubmed
9328833
uniprot
proteins
pubmed
9671816
uniprot
proteins
sequence_length
915
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19674106, ECO:0000269|PubMed:22693546}.
uniprot
proteins