Flrt2
entrez
399558
canonical
uniprot
Q8BLU0
canonical
ensembl
ENSMUSG00000047414
resolver
ensp
ENSMUSP00000062171
resolver
ensp
ENSMUSP00000105744
resolver
ensp
ENSMUSP00000301477
resolver
ensp
ENSMUSP00000301478
resolver
enst
ENSMUST00000057324
resolver
enst
ENSMUST00000110117
resolver
genesymbol
Flrt2
resolver
genesymbol_syn
Kiaa0405
resolver
uniprot
Q6A073
resolver
uniprot_entry
FLRT2_MOUSE
resolver
uniprot_sec
Q6A073
resolver
amino_acid_sequence
MGLQTTKWPGRGAFILKFWLIISLGLYLQVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFANLRKLERLDISNNQLRMLTQGVFDHLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPVFTPAPSTVSPTTQSPTLSVPSPSRGSVPPAPTPSKLPTIPDWDGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRTVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGSPFLLAGLIGGAVIFVLVVLLSVFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSILEMTETSFQIVSLNNDQLLKGDFRLQPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT
uniprot
proteins
function
FUNCTION: Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:21350012, PubMed:25374360, PubMed:25728924). May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D (PubMed:21673655). Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members (PubMed:21673655, PubMed:25728924). Plays a role in fibroblast growth factor-mediated signaling cascades (PubMed:16872596). Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis (PubMed:21350012). {ECO:0000269|PubMed:16872596, ECO:0000269|PubMed:21350012, ECO:0000269|PubMed:21673655, ECO:0000269|PubMed:25374360, ECO:0000269|PubMed:25728924}.
uniprot
proteins
mass_dalton
73948
uniprot
proteins
mutagenesis
MUTAGEN 170; /note="H->E,N: Abolishes interaction with UNC5D."; /evidence="ECO:0000269|PubMed:25374360"; MUTAGEN 186; /note="R->N: Abolishes homooligomerization and FLRT2-mediated cell-cell adhesion; when associated with T-188."; /evidence="ECO:0000269|PubMed:25374360"; MUTAGEN 188; /note="D->T: Abolishes homooligomerization and FLRT2-mediated cell-cell adhesion; when associated with N-186."; /evidence="ECO:0000269|PubMed:25374360"; MUTAGEN 248; /note="D->N: No effect on interaction with UNC5D; when associated with T-250."; /evidence="ECO:0000269|PubMed:25374360"; MUTAGEN 250; /note="P->T: No effect on interaction with UNC5D; when associated with N-248."; /evidence="ECO:0000269|PubMed:25374360
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:16872596, ECO:0000269|PubMed:21673655}.; PTM: Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease. {ECO:0000269|PubMed:21673655}.
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16872596
uniprot
proteins
pubmed
18448090
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21350012
uniprot
proteins
pubmed
21673655
uniprot
proteins
pubmed
21765038
uniprot
proteins
pubmed
22405201
uniprot
proteins
pubmed
24585683
uniprot
proteins
pubmed
25374360
uniprot
proteins
pubmed
25728924
uniprot
proteins
sequence_length
660
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16872596, ECO:0000269|PubMed:22405201, ECO:0000269|PubMed:24585683, ECO:0000269|PubMed:25374360}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:16872596, ECO:0000305|PubMed:24585683}. Cell junction, focal adhesion {ECO:0000269|PubMed:16872596}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:24585683}. Synapse, synaptosome {ECO:0000250|UniProtKB:D3ZTV3}. Microsome membrane {ECO:0000269|PubMed:24585683}. Secreted {ECO:0000269|PubMed:21673655}. Note=Proteolytic cleavage gives rise to a shedded ectodomain. {ECO:0000269|PubMed:21673655}.
uniprot
proteins
transmembrane_region
TRANSMEM 541..561; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins