MYO6
entrez
4646
canonical
uniprot
Q9UM54
canonical
ensembl
ENSG00000196586
resolver
ensp
ENSP00000358992
resolver
ensp
ENSP00000358994
resolver
ensp
ENSP00000359002
resolver
ensp
ENSP00000499278
resolver
ensp
ENSP00000500710
resolver
ensp
ENSP00000597952
resolver
ensp
ENSP00000597955
resolver
ensp
ENSP00000597956
resolver
ensp
ENSP00000618039
resolver
ensp
ENSP00000618041
resolver
ensp
ENSP00000783749
resolver
enst
ENST00000369975
resolver
enst
ENST00000664640
resolver
enst
ENST00000672093
resolver
enst
ENST00000927897
resolver
genesymbol
MYO6
resolver
genesymbol
Myo6-007
resolver
genesymbol_syn
KIAA0389
resolver
hgnc
HGNC:7605
resolver
uniprot
A0A0A0MRM8
resolver
uniprot
A0A1Y0BRN3
resolver
uniprot
A0A590UJ40
resolver
uniprot
A0A5F9ZHW4
resolver
uniprot
A6H8V4
resolver
uniprot
E1P540
resolver
uniprot
Q5TEM5
resolver
uniprot
Q5TEM6
resolver
uniprot
Q5TEM7
resolver
uniprot
Q9BZZ7
resolver
uniprot
Q9UEG2
resolver
uniprot_entry
A0A0A0MRM8_HUMAN
resolver
uniprot_entry
A0A1Y0BRN3_HUMAN
resolver
uniprot_entry
A0A590UJ40_HUMAN
resolver
uniprot_entry
A0A5F9ZHW4_HUMAN
resolver
uniprot_entry
MYO6_HUMAN
resolver
uniprot_sec
A6H8V4
resolver
uniprot_sec
E1P540
resolver
uniprot_sec
Q5TEM5
resolver
uniprot_sec
Q5TEM6
resolver
uniprot_sec
Q5TEM7
resolver
uniprot_sec
Q9BZZ7
resolver
uniprot_sec
Q9UEG2
resolver
amino_acid_sequence
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSGGCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSDQHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKKYMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAELVKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGLVKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYDALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEMEAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSEAELISDEAQADLALRRSLDSYPVSKNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAGTKKYDLSKWKYAELRDTINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDYDFAPFLNNSPQQNPAAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGPWIARQMELHPDKPPILLVAGKDDMEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQYLQNAIESRQARPTYATAMLQSLLK
uniprot
proteins
disease_involvement
DISEASE: Deafness, autosomal dominant, 22 (DFNA22) [MIM:606346]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA22 is progressive and postlingual, with onset during childhood. By the age of approximately 50 years, affected individuals invariably have profound sensorineural deafness. {ECO:0000269|PubMed:11468689}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Deafness, autosomal recessive, 37 (DFNB37) [MIM:607821]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269|PubMed:12687499}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Deafness, autosomal dominant 22, with hypertrophic cardiomyopathy (DFNHCM) [MIM:606346]: An autosomal dominant sensorineural deafness associated with hypertrophic cardiomyopathy. {ECO:0000269|PubMed:15060111}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (PubMed:23023224). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Required for the correct localization of CLIC5 and RDX at the stereocilium base (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370). {ECO:0000250|UniProtKB:Q29122, ECO:0000250|UniProtKB:Q64331, ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:29467281, ECO:0000269|PubMed:31371777}.
uniprot
proteins
mass_dalton
149691
uniprot
proteins
mutagenesis
MUTAGEN 1116..1118; /note="RRL->AAA: Decreased localization to autophagosomes."; /evidence="ECO:0000269|PubMed:23023224
uniprot
proteins
post_translational_modification
PTM: Phosphorylation in the motor domain, induced by EGF, results in translocation of MYO6 from the cell surface to membrane ruffles and affects F-actin dynamics. Phosphorylated in vitro by p21-activated kinase (PAK). {ECO:0000269|PubMed:9852149}.
uniprot
proteins
protein_family
Myosin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
10519557
uniprot
proteins
pubmed
11447109
uniprot
proteins
pubmed
11468689
uniprot
proteins
pubmed
11967127
uniprot
proteins
pubmed
12687499
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15044955
uniprot
proteins
pubmed
15060111
uniprot
proteins
pubmed
15247260
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16344560
uniprot
proteins
pubmed
16507995
uniprot
proteins
pubmed
16949370
uniprot
proteins
pubmed
18511944
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23023224
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29467281
uniprot
proteins
pubmed
31371777
uniprot
proteins
pubmed
9205841
uniprot
proteins
pubmed
9259267
uniprot
proteins
pubmed
9852149
uniprot
proteins
sequence_length
1294
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:16507995}; Peripheral membrane protein {ECO:0000269|PubMed:16507995}. Golgi apparatus {ECO:0000269|PubMed:16507995}. Nucleus {ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16507995}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:11447109}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:11447109}. Cell projection, filopodium {ECO:0000269|PubMed:9852149}. Cell projection, ruffle membrane {ECO:0000269|PubMed:16507995}. Cell projection, microvillus {ECO:0000269|PubMed:9852149}. Cytoplasm, cytosol {ECO:0000269|PubMed:16949370}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:23023224}. Endosome {ECO:0000269|PubMed:23023224}. Note=Also present in endocyctic vesicles (PubMed:16507995). Translocates from membrane ruffles, endocytic vesicles and cytoplasm to Golgi apparatus, perinuclear membrane and nucleus through induction by p53 and p53-induced DNA damage (PubMed:16507995). Recruited into membrane ruffles from cell surface by EGF-stimulation (PubMed:9852149). Colocalizes with DAB2 in clathrin-coated pits/vesicles (PubMed:11967127). Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane (By similarity). Recruited to endosomes by TOM1 and TOM1L2 (PubMed:23023224). {ECO:0000250|UniProtKB:Q9I8D1, ECO:0000269|PubMed:11967127, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:9852149}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:11447109}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasmic vesicle, clathrin-coated vesicle membrane. Cell projection, ruffle membrane {ECO:0000269|PubMed:11447109}.
uniprot
proteins