EOMES
entrez
8320
canonical
uniprot
O95936
canonical
ensembl
ENSG00000163508
resolver
ensp
ENSP00000295743
resolver
ensp
ENSP00000388620
resolver
ensp
ENSP00000487112
resolver
genesymbol
EOMES
resolver
genesymbol_syn
TBR2
resolver
hgnc
HGNC:3372
resolver
uniprot
B7Z4I2
resolver
uniprot
B7Z4K0
resolver
uniprot
B7ZA51
resolver
uniprot
G3XAI5
resolver
uniprot
Q8TAZ2
resolver
uniprot
Q9UPM7
resolver
uniprot_entry
B7Z4K0_HUMAN
resolver
uniprot_entry
EOMES_HUMAN
resolver
uniprot_sec
B7Z4I2
resolver
uniprot_sec
B7ZA51
resolver
uniprot_sec
G3XAI5
resolver
uniprot_sec
Q8TAZ2
resolver
uniprot_sec
Q9UPM7
resolver
amino_acid_sequence
MQLGEQLLVSSVNLPGAHFYPLESARGGSGGSAGHLPSAAPSPQKLDLDKASKKFSGSLSCEAVSGEPAAASAGAPAAMLSDTDAGDAFASAAAVAKPGPPDGRKGSPCGEEELPSAAAAAAAAAAAAAATARYSMDSLSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAPHGPVYPAPNGARYPYGSMLPPGGFPAAVCPPGRAQFGPGAGAGSGAGGSSGGGGGPGTYQYSQGAPLYGPYPGAAAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSSHQIVPGGRYGVQSFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQQPGTNKLDISSYESEYTSSTLLPYGIKSLPLQTSHALGYYPDPTFPAMAGWGGRGSYQRKMAAGLPWTSRTSPTVFSEDQLSKEKVKEEIGSSWIETPPSIKSLDSNDSGVYTSACKRRRLSPSNSSNENSPSIKCEDINAEEYSKDTSKGMGGYYAFYTTP
uniprot
proteins
disease_involvement
DISEASE: Note=A translocation t(3;10)(p24;q23) located 215 kb 3' to the EOMES gene but leading to loss of its expression was identified in a large consanguineous family. Homozygous silencing produces microcephaly associated with corpus callosum agenesis, bilateral polymicrogyria, ventricular dilatation and a small cerebellum.
uniprot
proteins
function
FUNCTION: Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex (PubMed:17353897). Required for differentiation and migration of unipolar dendritic brush cells (PubMed:33488348). Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes (PubMed:17566017). {ECO:0000269|PubMed:17353897, ECO:0000269|PubMed:17566017, ECO:0000269|PubMed:33488348}.
uniprot
proteins
mass_dalton
72732
uniprot
proteins
pubmed
10407135
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17353897
uniprot
proteins
pubmed
17566017
uniprot
proteins
pubmed
18316326
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
33488348
uniprot
proteins
pubmed
9888994
uniprot
proteins
sequence_length
686
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins