Atad1
entrez
309532
canonical
uniprot
Q505J9
canonical
ensembl
ENSRNOG00000010861
resolver
ensp
ENSRNOP00000014684
resolver
genesymbol
Atad1
resolver
genesymbol_syn
Npg6
resolver
uniprot
B3STU2
resolver
uniprot_entry
ATAD1_RAT
resolver
uniprot_sec
B3STU2
resolver
amino_acid_sequence
MVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHLVDPLNMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHINQPALKQREAILKLILKNENVDRHVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNSTSEESHDEDEIRPVQQQDLHRAIEKMKKSKDAAFQSVLTHVCLD
uniprot
proteins
ec_number
7.4.2.-
uniprot
proteins
function
FUNCTION: Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (PubMed:21496646). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (PubMed:21496646). {ECO:0000250|UniProtKB:P28737, ECO:0000250|UniProtKB:Q8NBU5, ECO:0000269|PubMed:21496646}.
uniprot
proteins
mass_dalton
40717
uniprot
proteins
mutagenesis
MUTAGEN 139; /note="K->T: ATPase activity reduced by 60%-70%. ATPase activity reduced by 92%; when associated with Q-193."; /evidence="ECO:0000269|PubMed:21496646"; MUTAGEN 193; /note="E->Q: ATPase activity reduced by 60%-70%. ATPase activity reduced by 92%; when associated with T-139."; /evidence="ECO:0000269|PubMed:21496646
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
protein_family
MSP1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21124846
uniprot
proteins
pubmed
21496646
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8NBU5}; Single-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000250|UniProtKB:Q8NBU5}; Single-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9D5T0}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..32; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins