MPHOSPH9
entrez
10198
canonical
uniprot
Q99550
canonical
ensembl
ENSG00000051825
resolver
ensp
ENSP00000304096
resolver
ensp
ENSP00000475489
resolver
ensp
ENSP00000578566
resolver
ensp
ENSP00000578568
resolver
ensp
ENSP00000578569
resolver
ensp
ENSP00000588181
resolver
ensp
ENSP00000632808
resolver
ensp
ENSP00000682783
resolver
ensp
ENSP00000744195
resolver
ensp
ENSP00000744197
resolver
ensp
ENSP00000744198
resolver
ensp
ENSP00000744199
resolver
genesymbol
MPHOSPH9
resolver
genesymbol_syn
MPP9
resolver
hgnc
HGNC:7215
resolver
uniprot
A0A0A0MTP3
resolver
uniprot
A1L486
resolver
uniprot
A6NEE2
resolver
uniprot
B3KR87
resolver
uniprot
Q9H976
resolver
uniprot
U3KQ28
resolver
uniprot_entry
MPP9_HUMAN
resolver
uniprot_sec
A0A0A0MTP3
resolver
uniprot_sec
A1L486
resolver
uniprot_sec
A6NEE2
resolver
uniprot_sec
B3KR87
resolver
uniprot_sec
Q9H976
resolver
uniprot_sec
U3KQ28
resolver
amino_acid_sequence
MEEFDLVKTLHKTSSSVGSDENSLHSLGLNLNTDRSSPHLSTNGVSSFSGKTRPSVIQGTVEVLTSLMQELQNSGKTDSELWKNCETRWLQLFNLVEKQCQEQIVAQQEQFHNQIQHIQEEIKNLVKLQTSSASLASCEGNSSNKQVSSESQMGFFSLSSERNESVIHYPESTEPEIQQEMSTSQPDCNVDSCSVSSGYGTFCISELNLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDGVKNENFYIQTPEECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSWAQKLKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEKSDFAAATHPRAFYLSKPDETPNAWMSDSGTGLTYWKLEEKDMHHSLPETLEKTFISLSSTDVSPNQSNTSNEMKLPSLKDIYYKKQRENKQLPERNLTSASNPNHPPEVLTLDPTLHMKPKQQISGIQPHGLPNALDDRISFSPDSVLEPSMSSPSDIDSFSQASNVTSQLPGFPKYPSHTKASPVDSWKNQTFQNESRTSSTFPSVYTITSNDISVNTVDEENTVMVASASVSQSQLPGTANSVPECISLTSLEDPVILSKIRQNLKEKHARHIADLRAYYESEINSLKQKLEAKEISGVEDWKITNQILVDRCGQLDSALHEATSRVRTLENKNNLLEIEVNDLRERFSAASSASKILQERIEEMRTSSKEKDNTIIRLKSRLQDLEEAFENAYKLSDDKEAQLKQENKMFQDLLGEYESLGKEHRRVKDALNTTENKLLDAYTQISDLKRMISKLEAQVKQVEHENMLSLRHNSRIHVRPSRANTLATSDVSRRKWLIPGAEYSIFTGQPLDTQDSNVDNQLEETCSLGHRSPLEKDSSPGSSSTSLLIKKQRETSDTPIMRALKELDEGKIFKNWGTQTEKEDTSNINPRQTETSVNASRSPEKCAQQRQKRLNSASQRSSSLPPSNRKSSTPTKREIMLTPVTVAYSPKRSPKENLSPGFSHLLSKNESSPIRFDILLDDLDTVPVSTLQRTNPRKQLQFLPLDDSEEKTYSEKATDNHVNHSSCPEPVPNGVKKVSVRTAWEKNKSVSYEQCKPVSVTPQGNDFEYTAKIRTLAETERFFDELTKEKDQIEAALSRMPSPGGRITLQTRLNQEALEDRLERINRELGSVRMTLKKFHVLRTSANL
uniprot
proteins
function
FUNCTION: Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (PubMed:30375385). {ECO:0000269|PubMed:30375385}.
uniprot
proteins
mass_dalton
133024
uniprot
proteins
mutagenesis
MUTAGEN 781; /note="S->A: Loss of phosphorylation and localization at distal ends of the mother centriole. Significant decrease in ubiquitination; when associated with A-788."; /evidence="ECO:0000269|PubMed:30375385"; MUTAGEN 784; /note="K->A: Decreased ubiquitination and increased protein stability."; /evidence="ECO:0000269|PubMed:30375385"; MUTAGEN 788; /note="S->A: Reduced phosphorylation. Significant decrease in ubiquitination; when associated with A-781."; /evidence="ECO:0000269|PubMed:30375385
uniprot
proteins
post_translational_modification
PTM: TTBK2-mediated phosphorylation at Ser-781 and Ser-788, promotes its ubiquitination at Lys-784 leading to proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Phosphorylated in M (mitotic) phase (PubMed:8885239). {ECO:0000269|PubMed:30375385, ECO:0000269|PubMed:8885239}.; PTM: Ubiquitinated at Lys-784, leading to proteasomal degradation. {ECO:0000269|PubMed:30375385}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21399614
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30375385
uniprot
proteins
pubmed
8885239
uniprot
proteins
sequence_length
1183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:30375385}. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30375385}. Note=Localizes to the distal and proximal end of centriole pairs in duplicated centrosomes. In ciliated cells, localizes to the distal and proximal end of daughter centriole and proximal of the mother centriole but not in the distal end of the mother centriole (PubMed:21399614). Recruited by KIF24 to the distal end of mother centriole where it forms a ring-like structure (PubMed:30375385). {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:30375385}.
uniprot
proteins