Chi3l1
entrez
89824
canonical
uniprot
Q9WTV1
canonical
ensembl
ENSRNOG00000053272
resolver
ensp
ENSRNOP00000074871
resolver
ensp
ENSRNOP00000091690
resolver
enst
ENSRNOT00000078599
resolver
enst
ENSRNOT00000108902
resolver
genesymbol
Chi3l1
resolver
uniprot
A0A8I6AFN7
resolver
uniprot
Q5BJR6
resolver
uniprot_entry
A0A8I6AFN7_RAT
resolver
uniprot_entry
CH3L1_RAT
resolver
uniprot_sec
Q5BJR6
resolver
amino_acid_sequence
MTLQLPGFAVLMLLQSCSAYKLVCYYTNWSQYREGNGSCFPDALDHSLCTHIIYSFANISNNKLSTSEWNDVTLYGMLNTLKTRNPRLKTLLSVGGWSFGSERFSRIVSNAKSRKTFVQSVAPFLRTYGFDGLDLAWLYPGPKDKQHFTTLIKELKAEFTKEVQPGTEKLLLSAAVSAGKVTLDSGYDVAQIAQHLDFINLMTYDFHGTWRHTTGHHSPLFRGQQDTGPDRFSNVDYGVGYMLRLGAPTNKLVMGIPTFGKSFTLASSENQVGAPITGSGLPGRYTKEKGTLAYYEICDFLRGAEVHRILGQQVPFATKGNQWVGYDDPESVKNKVKYLKNKQLAGAMVWAVDLDDFRGSFCGHNVHFPLTNAIKEALAVA
uniprot
proteins
function
FUNCTION: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
42392
uniprot
proteins
protein_family
Glycosyl hydrolase 18 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
uniprot
proteins