Tom1l1
entrez
71943
canonical
uniprot
Q923U0
canonical
ensembl
ENSMUSG00000020541
resolver
ensp
ENSMUSP00000020849
resolver
ensp
ENSMUSP00000103499
resolver
ensp
ENSMUSP00000103500
resolver
ensp
ENSMUSP00000103501
resolver
enst
ENSMUST00000107868
resolver
genesymbol
Tom1l1
resolver
genesymbol_syn
Srcasm
resolver
uniprot
B0QZV4
resolver
uniprot
F6THX0
resolver
uniprot
Q5SRC7
resolver
uniprot
Q5SRC9
resolver
uniprot
Q8BZR6
resolver
uniprot
Q99KE0
resolver
uniprot
Q9D6Y5
resolver
uniprot_entry
F6THX0_MOUSE
resolver
uniprot_entry
Q8BZR6_MOUSE
resolver
uniprot_entry
TM1L1_MOUSE
resolver
uniprot_sec
B0QZV4
resolver
uniprot_sec
Q5SRC7
resolver
uniprot_sec
Q5SRC9
resolver
uniprot_sec
Q99KE0
resolver
uniprot_sec
Q9D6Y5
resolver
amino_acid_sequence
MAFGKSHRDPYATSVGHLIEKATFAGVLTEDWGQFLHICDIINTTQDGPKDAVKALKKRISKNYNHKEIQLSLSLIDMCVQNCGPSFQSLIVKKEFIKDTLVKLLNPRYTLPLETQNRILNFIKTWSQGFPGGVDVSEVKEVYLDLLKKGVQFPPSDGEPETRQEAGQISPNRPTSVPTAPALSSIIAPKNPTISLVPEQIGKLHSELDMVKMNVKVMTAILMENTPGSENHEDIELLRKLYKTGREMQERIMDLLVVVENEDVTMELIQVNEDLNNAVLGYERFTRNQQRLLEQKRNRTEATRTSSEPSAPSCDLLDLSPIVPVPTPNEGALNSVNAQLSGLSVSSLSPVITNNLYPSLQPQRDLLASEDIEIPTLFPQRTSQNLASSHTYDNFHSNSVLLQPVSLHTATAAAAANQRLPPLPSSHPVLKDGDLQPPNYYEVMEFDPLAPTTEAVYEEIDGYHQKEAQSHSDC
uniprot
proteins
function
FUNCTION: Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions. {ECO:0000269|PubMed:11711534}.
uniprot
proteins
mass_dalton
52695
uniprot
proteins
mutagenesis
MUTAGEN 392; /note="Y->F: Specifically abolishes interaction with GRB2; mild decrease in phosphorylation."; /evidence="ECO:0000269|PubMed:11711534"; MUTAGEN 440..441; /note="YY->FF: Specifically abolishes interaction with PIK3R1; mild decrease in phosphorylation."; /evidence="ECO:0000269|PubMed:11711534"; MUTAGEN 457; /note="Y->F: Abolishes phosphorylation by FYN and interaction with FYN."; /evidence="ECO:0000269|PubMed:11711534
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines by LYN (By similarity). Phosphorylated on tyrosines by FYN. {ECO:0000250, ECO:0000269|PubMed:11711534}.
uniprot
proteins
protein_family
TOM1 family
uniprot
proteins
pubmed
11711534
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack. Endosome membrane {ECO:0000305}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=A small proportion is membrane-associated. {ECO:0000250}.
uniprot
proteins