Stmn1
entrez
29332
canonical
uniprot
P13668
canonical
ensembl
ENSRNOG00000016810
resolver
ensp
ENSRNOP00000022574
resolver
enst
ENSRNOT00000022574
resolver
genesymbol
Stmn1
resolver
genesymbol_syn
Lap18
resolver
uniprot_entry
STMN1_RAT
resolver
amino_acid_sequence
MASSDIQVKELEKRASGQAFELILSPRSKESVPEFPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHVEEVRKNKESKDPADETEAD
uniprot
proteins
function
FUNCTION: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules (By similarity). Its phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250, ECO:0000269|PubMed:16982419}.
uniprot
proteins
mass_dalton
17288
uniprot
proteins
post_translational_modification
PTM: Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF (By similarity). Phosphorylation at Ser-16 is higher in the developing axons from hippocampal neurons and seems to be required for neuron polarization. {ECO:0000250, ECO:0000269|PubMed:16982419, ECO:0000269|Ref.7}.
uniprot
proteins
protein_family
Stathmin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16982419
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2745432
uniprot
proteins
pubmed
2776625
uniprot
proteins
sequence_length
149
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
uniprot
proteins