Homer2
entrez
26557
canonical
uniprot
Q9QWW1
canonical
ensembl
ENSMUSG00000025813
resolver
ensp
ENSMUSP00000026922
resolver
ensp
ENSMUSP00000095931
resolver
ensp
ENSMUSP00000146787
resolver
enst
ENSMUST00000098326
resolver
genesymbol
Homer2
resolver
genesymbol_syn
Vesl2
resolver
uniprot
E9Q4F9
resolver
uniprot
O89025
resolver
uniprot
Q9Z0E4
resolver
uniprot_entry
E9Q4F9_MOUSE
resolver
uniprot_entry
HOME2_MOUSE
resolver
uniprot_sec
O89025
resolver
uniprot_sec
Q9Z0E4
resolver
amino_acid_sequence
MGEQPIFTTRAHVFQIDPSTKKNWVPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSELQLTKFAEKFQEVREAARLARDKSQEKTETSSNHSQESGCETPSSTQASSVNGTDDEKASHASPADTHLKSENDKLKIALTQSAANVKKWEMELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRSKIEELEEQCSEINREKEKNTQLKRRIEELESEVRDKEMELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKGELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
uniprot
proteins
function
FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity) Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity). {ECO:0000250|UniProtKB:Q9NSB8, ECO:0000269|PubMed:25816005}.
uniprot
proteins
mass_dalton
40570
uniprot
proteins
protein_family
Homer family
uniprot
proteins
pubmed
11491285
uniprot
proteins
pubmed
25816005
uniprot
proteins
pubmed
9808458
uniprot
proteins
pubmed
9808459
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NSB8}. Cell membrane {ECO:0000250|UniProtKB:O88801}. Postsynaptic density. Synapse. Cell projection, stereocilium {ECO:0000269|PubMed:25816005}. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
uniprot
proteins