FBXW11
entrez
23291
canonical
uniprot
Q9UKB1
canonical
ensembl
ENSG00000072803
resolver
ensp
ENSP00000265094
resolver
ensp
ENSP00000296933
resolver
ensp
ENSP00000377391
resolver
ensp
ENSP00000428753
resolver
ensp
ENSP00000632411
resolver
ensp
ENSP00000632412
resolver
enst
ENST00000517395
resolver
enst
ENST00000962353
resolver
genesymbol
FBXW11
resolver
genesymbol_syn
BTRCP2
resolver
genesymbol_syn
FBW1B
resolver
genesymbol_syn
FBXW1B
resolver
genesymbol_syn
KIAA0696
resolver
hgnc
HGNC:13607
resolver
uniprot
B2RC98
resolver
uniprot
B4DH70
resolver
uniprot
E5RGC1
resolver
uniprot
Q9P2S8
resolver
uniprot
Q9P2S9
resolver
uniprot
Q9Y4C6
resolver
uniprot_entry
B4DH70_HUMAN
resolver
uniprot_entry
E5RGC1_HUMAN
resolver
uniprot_entry
FBW1B_HUMAN
resolver
uniprot_sec
B2RC98
resolver
uniprot_sec
Q9P2S8
resolver
uniprot_sec
Q9P2S9
resolver
uniprot_sec
Q9Y4C6
resolver
amino_acid_sequence
MEPDSVIEDKTIELMCSVPRSLWLGCANLVESMCALSCLQSMPSVRCLQISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR
uniprot
proteins
disease_involvement
DISEASE: Neurodevelopmental, jaw, eye, and digital syndrome (NEDJED) [MIM:618914]: An autosomal dominant syndrome characterized by variable features including mild-to-severe developmental delay, speech delay, autistic and/or stereotypical behaviors, ocular anomalies, under- or overdeveloped jaw, and digital anomalies such as brachydactyly, clinodactyly, syndactyly, and contractures. {ECO:0000269|PubMed:31402090}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10437795, PubMed:10648623, PubMed:11158290, PubMed:19966869, PubMed:20347421, PubMed:22017875, PubMed:22017876, PubMed:36608670). Probably recognizes and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S (PubMed:10437795, PubMed:10648623, PubMed:19966869, PubMed:20347421, PubMed:22017875, PubMed:22017876, PubMed:36608670). SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation (PubMed:10321728). SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription (PubMed:10321728, PubMed:10437795, PubMed:10644755, PubMed:20347421). The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation (PubMed:11158290). SCF(FBXW11) mediates the ubiquitination of IFNAR1 (PubMed:14532120, PubMed:15337770). SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1 (PubMed:18575781). Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint (PubMed:14603323). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2 (PubMed:15917222). SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262). SCF(FBXW11) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF (PubMed:22017875, PubMed:22017876, PubMed:36608670). {ECO:0000269|PubMed:10321728, ECO:0000269|PubMed:10437795, ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:10648623, ECO:0000269|PubMed:11158290, ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:14603323, ECO:0000269|PubMed:15337770, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18575781, ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:20347421, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:29420262, ECO:0000269|PubMed:36608670}.; FUNCTION: (Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action. {ECO:0000269|PubMed:19730691}.
uniprot
proteins
mass_dalton
62091
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:10321728, ECO:0000269|PubMed:10437795, ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:11158290, ECO:0000269|PubMed:20347421, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:36608670}.
uniprot
proteins
pubmed
10066435
uniprot
proteins
pubmed
10321728
uniprot
proteins
pubmed
10437795
uniprot
proteins
pubmed
10531035
uniprot
proteins
pubmed
10644755
uniprot
proteins
pubmed
10648623
uniprot
proteins
pubmed
10694485
uniprot
proteins
pubmed
11158290
uniprot
proteins
pubmed
11850814
uniprot
proteins
pubmed
14532120
uniprot
proteins
pubmed
14603323
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15337770
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15917222
uniprot
proteins
pubmed
16880511
uniprot
proteins
pubmed
18354482
uniprot
proteins
pubmed
18575781
uniprot
proteins
pubmed
19730691
uniprot
proteins
pubmed
19966869
uniprot
proteins
pubmed
20347421
uniprot
proteins
pubmed
22017875
uniprot
proteins
pubmed
22017876
uniprot
proteins
pubmed
25503564
uniprot
proteins
pubmed
26837067
uniprot
proteins
pubmed
29420262
uniprot
proteins
pubmed
31402090
uniprot
proteins
pubmed
36608670
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
542
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5SRY7}. Nucleus {ECO:0000250|UniProtKB:Q5SRY7}.
uniprot
proteins