Esr1
entrez
13982
canonical
uniprot
P19785
canonical
ensembl
ENSMUSG00000019768
resolver
ensp
ENSMUSP00000070070
resolver
ensp
ENSMUSP00000101213
resolver
ensp
ENSMUSP00000101214
resolver
ensp
ENSMUSP00000101215
resolver
ensp
ENSMUSP00000260616
resolver
enst
ENSMUST00000067086
resolver
enst
ENSMUST00000105589
resolver
enst
ENSMUST00000105590
resolver
genesymbol
Esr1
resolver
genesymbol_syn
ESR1
resolver
genesymbol_syn
Esr
resolver
genesymbol_syn
Estr
resolver
genesymbol_syn
Estra
resolver
genesymbol_syn
Nr3a1
resolver
uniprot
A0A1W7GYW9
resolver
uniprot
E7FJU2
resolver
uniprot
Q9JJT5
resolver
uniprot
Q9QY51
resolver
uniprot
Q9QY52
resolver
uniprot_entry
A0A1W7GYW9_MOUSE
resolver
uniprot_entry
E7FJU2_MOUSE
resolver
uniprot_entry
ESR1_MOUSE
resolver
uniprot_sec
Q9JJT5
resolver
uniprot_sec
Q9QY51
resolver
uniprot_sec
Q9QY52
resolver
amino_acid_sequence
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPTVFNYPEGAAYEFNAAAAAAAAASAPVYGQSGIAYGPGSEAAAFSANSLGAFPQLNSVSPSPLMLLHPPPQLSPFLHPHGQQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSNEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGASGDMRAANLWPSPLVIKHTKKNSPALSLTADQMVSALLDAEPPMIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASRMGVPPEEPSQTQLATTSSTSAHSLQTYYIPPEAEGFPNTI
uniprot
proteins
function
FUNCTION: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10207113, ECO:0000269|PubMed:10840033}.
uniprot
proteins
mass_dalton
66955
uniprot
proteins
mutagenesis
MUTAGEN 362; /note="I->A: No effect on transcriptional activity and estrogen-induced interaction with NCOA1. Abolishes estrogen-induced interaction with NCOA1; when associated with A-376 and A-380."; /evidence="ECO:0000269|PubMed:10207113"; MUTAGEN 362; /note="I->D: Abolishes transcriptional activity and estrogen-induced interaction with NCOA1."; /evidence="ECO:0000269|PubMed:10207113"; MUTAGEN 366; /note="K->A: Greatly reduces transcriptional activity and estrogen-induced interaction with NCOA1."; /evidence="ECO:0000269|PubMed:10207113"; MUTAGEN 366; /note="K->D: Abolishes transcriptional activity and estrogen-induced interaction with NCOA1."; /evidence="ECO:0000269|PubMed:10207113"; MUTAGEN 366; /note="K->L: Reduces transcriptional activity and estrogen-induced interaction with NCOA1."; /evidence="ECO:0000269|PubMed:10207113"; MUTAGEN 371; /note="F->A: Abolishes estrogen-dependent NF-kappa B transcriptional repression, impairs transcriptional activity, abolishes estrogen-induced interaction with NCOA1."; /evidence="ECO:0000269|PubMed:10840033"; MUTAGEN 376; /note="L->A: Reduces transcriptional activity, no effect on estrogen-induced interaction with NCOA1. Abolishes estrogen-induced interaction with NCOA1; when associated with A-362 and A-380."; /evidence="ECO:0000269|PubMed:10207113"; MUTAGEN 376; /note="L->D: Reduces transcriptional activity and estrogen-induced interaction with NCOA1."; /evidence="ECO:0000269|PubMed:10207113"; MUTAGEN 380; /note="V->A: No effect on transcriptional activity and estrogen-induced interaction with NCOA1. Abolishes estrogen-induced interaction with NCOA1; when associated with A-362 and A-376."; /evidence="ECO:0000269|PubMed:10207113"; MUTAGEN 380; /note="V->D: Abolishes transcriptional activity and estrogen-induced interaction with NCOA1."; /evidence="ECO:0000269|PubMed:10207113"; MUTAGEN 451; /note="C->A: Loss of ZDHHC7 and ZDHHC21 binding. Loss of palmitoylation."; /evidence="ECO:0000269|PubMed:22031296"; MUTAGEN 508; /note="L->A: Reduces DNA-binding, attenuates transcriptional activity, does not effect estrogen-dependent NF-kappa B transcriptional repression; when associated with E-512 and E-515."; /evidence="ECO:0000269|PubMed:10840033"; MUTAGEN 508; /note="L->E: Abolishes DNA-binding, abolishes transcriptional activity and estrogen-dependent NF-kappa B transcriptional repression; when associated with E-512 and E-515."; /evidence="ECO:0000269|PubMed:10840033"; MUTAGEN 509; /note="A->E: Reduces DNA-binding,, attenuates transcriptional activity, does not effect estrogen-dependent NF-kappa B transcriptional repression."; /evidence="ECO:0000269|PubMed:10840033"; MUTAGEN 512; /note="L->A: Reduces DNA-binding, attenuates transcriptional activity, does not effect estrogen-dependent NF-kappa B transcriptional repression; when associated with E-508 and E-515."; /evidence="ECO:0000269|PubMed:10840033"; MUTAGEN 512; /note="L->E: Abolishes DNA-binding, abolishes transcriptional activity and estrogen-dependent NF-kappa B transcriptional repression; when associated with E-508 and E-515."; /evidence="ECO:0000269|PubMed:10840033"; MUTAGEN 515; /note="L->A: Reduces DNA-binding, attenuates transcriptional activity, does not effect estrogen-dependent NF-kappa B transcriptional repression; when associated with E-508 and E-512."; /evidence="ECO:0000269|PubMed:10840033"; MUTAGEN 515; /note="L->E: Abolishes DNA-binding, abolishes transcriptional activity and estrogen-dependent NF-kappa B transcriptional repression; when associated with E-508 and E-512."; /evidence="ECO:0000269|PubMed:10840033"; MUTAGEN 525; /note="G->R: Abolishes estrogen binding; impairs repression of NF-kappa activity."; /evidence="ECO:0000269|PubMed:10840033"; MUTAGEN 542; /note="D->N: Abolishes estrogen-dependent NF-kappa B transcriptional repression, impairs transcriptional activity, impairs estrogen-induced interaction with NCOA1; when associated with Q-546 and N-548."; /evidence="ECO:0000269|PubMed:10840033"; MUTAGEN 543..544; /note="LL->AA: Abolishes estrogen-dependent NF-kappa B transcriptional repression, abolishes estrogen-induced interaction with NCOA1."; /evidence="ECO:0000269|PubMed:10840033"; MUTAGEN 543; /note="L->A: Abolishes estrogen-induced interaction with NCOA1."; /evidence="ECO:0000269|PubMed:10207113"; MUTAGEN 546; /note="E->Q: Abolishes estrogen-dependent NF-kappa B transcriptional repression, impairs transcriptional activity, impairs estrogen-induced interaction with NCOA1; when associated with N-542 and N-548."; /evidence="ECO:0000269|PubMed:10840033"; MUTAGEN 547..548; /note="ML->AA: No effect on estrogen-dependent NF-kappa B transcriptional repression, greatly impairs transcriptional activity, abolishes estrogen-induced interaction with NCOA1."; /evidence="ECO:0000269|PubMed:10840033"; MUTAGEN 549; /note="D->N: Abolishes estrogen-dependent NF-kappa B transcriptional repression, impairs transcriptional activity, impairs estrogen-induced interaction with NCOA1; when associated with N-542 and Q-546."; /evidence="ECO:0000269|PubMed:10840033
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by cyclin A/CDK2 and. Dephosphorylation at Ser-122 by PPP5C inhibits its transactivation activity (By similarity). Phosphorylated by LMTK3 (in vitro) (By similarity). {ECO:0000250|UniProtKB:P03372}.; PTM: Ubiquitinated. Deubiquitinated by OTUB1 (By similarity). {ECO:0000250}.; PTM: Palmitoylated at Cys-451 by ZDHHC7 and ZDHHC21. This modification is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor. {ECO:0000269|PubMed:22031296}.; PTM: Ubiquitinated; regulated by LATS1 via DCAF1 it leads to ESR1 proteasomal degradation. Deubiquitinated by OTUB1 (By similarity). Ubiquitinated by STUB1/CHIP; in the CA1 hippocampal region following loss of endogenous circulating estradiol (17-beta-estradiol/E2) (By similarity). Ubiquitinated by UBR5, leading to its degradation: UBR5 specifically recognizes and binds ligand-bound ESR1 when it is not associated with coactivators (NCOAs). In presence of NCOAs, the UBR5-degron is not accessible, preventing its ubiquitination and degradation (By similarity). {ECO:0000250|UniProtKB:P03372, ECO:0000250|UniProtKB:P06211}.; PTM: Dimethylated by PRMT1 at Arg-264. The methylation may favor cytoplasmic localization. Demethylated by JMJD6 at Arg-264. {ECO:0000250|UniProtKB:P03372}.
uniprot
proteins
protein_family
NR3 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10207113
uniprot
proteins
pubmed
10788465
uniprot
proteins
pubmed
10840033
uniprot
proteins
pubmed
10899303
uniprot
proteins
pubmed
11226831
uniprot
proteins
pubmed
11704680
uniprot
proteins
pubmed
15140878
uniprot
proteins
pubmed
15988012
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17595322
uniprot
proteins
pubmed
20005806
uniprot
proteins
pubmed
22031296
uniprot
proteins
pubmed
2484714
uniprot
proteins
pubmed
7641693
uniprot
proteins
pubmed
8999954
uniprot
proteins
pubmed
9192892
uniprot
proteins
pubmed
9448000
uniprot
proteins
sequence_length
599
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated. {ECO:0000250}.
uniprot
proteins