Kitlg
entrez
17311
canonical
uniprot
P20826
canonical
ensembl
ENSMUSG00000019966
resolver
ensp
ENSMUSP00000020129
resolver
ensp
ENSMUSP00000100920
resolver
genesymbol
Kitlg
resolver
genesymbol_syn
Kitl
resolver
genesymbol_syn
Mgf
resolver
genesymbol_syn
Sl
resolver
genesymbol_syn
Slf
resolver
uniprot
P97332
resolver
uniprot
Q3TNJ7
resolver
uniprot
Q62524
resolver
uniprot
Q64222
resolver
uniprot
Q921N5
resolver
uniprot_entry
SCF_MOUSE
resolver
uniprot_sec
P97332
resolver
uniprot_sec
Q3TNJ7
resolver
uniprot_sec
Q62524
resolver
uniprot_sec
Q64222
resolver
uniprot_sec
Q921N5
resolver
amino_acid_sequence
MKKTQTWIITCIYLQLLLFNPLVKTKEICGNPVTDNVKDITKLVANLPNDYMITLNYVAGMDVLPSHCWLRDMVIQLSLSLTTLLDKFSNISEGLSNYSIIDKLGKIVDDLVLCMEENAPKNIKESPKRPETRSFTPEEFFSIFNRSIDAFKDFMVASDTSDCVLSSTLGPEKDSRVSVTKPFMLPPVAASSLRNDSSSSNRKAAKAPEDSGLQWTAMALPALISLVIGFAFGALYWKKKQSSLTRAVENIQINEEDNEISMLQQKEREFQEV
uniprot
proteins
function
FUNCTION: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
uniprot
proteins
mass_dalton
30645
uniprot
proteins
post_translational_modification
PTM: A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain.
uniprot
proteins
protein_family
SCF family
uniprot
proteins
pubmed
1378327
uniprot
proteins
pubmed
1383087
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1698553
uniprot
proteins
pubmed
1698554
uniprot
proteins
pubmed
1698556
uniprot
proteins
pubmed
1698557
uniprot
proteins
pubmed
1698558
uniprot
proteins
pubmed
1705866
uniprot
proteins
pubmed
17255936
uniprot
proteins
pubmed
26522471
uniprot
proteins
pubmed
8849898
uniprot
proteins
pubmed
8875893
uniprot
proteins
pubmed
9360640
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:P21583}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:P21583}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P21583}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P21583}. Cell projection, filopodium {ECO:0000250|UniProtKB:P21583}.; SUBCELLULAR LOCATION: [Soluble KIT ligand]: Secreted {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 215..237; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins