Ppp2cb
entrez
19053
canonical
uniprot
P62715
canonical
ensembl
ENSMUSG00000009630
resolver
ensp
ENSMUSP00000009774
resolver
enst
ENSMUST00000009774
resolver
genesymbol
Ppp2cb
resolver
uniprot
P11082
resolver
uniprot
Q8BN07
resolver
uniprot_entry
PP2AB_MOUSE
resolver
uniprot_entry
Q8BN07_MOUSE
resolver
uniprot_sec
P11082
resolver
amino_acid_sequence
MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000250|UniProtKB:P62714}.
uniprot
proteins
mass_dalton
35575
uniprot
proteins
mutagenesis
MUTAGEN 307; /note="Y->Q: Loss of trimeric subunit ABC assembly."; /evidence="ECO:0000269|PubMed:10441131"; MUTAGEN 309; /note="L->A: Loss of binding to PP2AB-alpha regulatory subunit."; /evidence="ECO:0000269|PubMed:10441131"; MUTAGEN 309; /note="L->Q: Loss of trimeric subunit ABC assembly."; /evidence="ECO:0000269|PubMed:10441131
uniprot
proteins
post_translational_modification
PTM: Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (Lcmt1) and protein phosphatase methylesterase 1 (Ppme1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization (By similarity). {ECO:0000250}.; PTM: Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation (By similarity). {ECO:0000250}.; PTM: May be monoubiquitinated by NOSIP. {ECO:0000269|PubMed:25546391}.
uniprot
proteins
protein_family
PP-1 subfamily
uniprot
proteins
protein_family
PPP phosphatase family
uniprot
proteins
pubmed
10441131
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25546391
uniprot
proteins
pubmed
7510677
uniprot
proteins
pubmed
8077208
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62714}. Nucleus {ECO:0000250|UniProtKB:P62714}. Chromosome, centromere {ECO:0000250|UniProtKB:P62714}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P62714}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. {ECO:0000250|UniProtKB:P62714}.
uniprot
proteins