HBEGF
entrez
1839
canonical
uniprot
Q99075
canonical
ensembl
ENSG00000113070
resolver
ensp
ENSP00000230990
resolver
ensp
ENSP00000620503
resolver
enst
ENST00000230990
resolver
enst
ENST00000950444
resolver
genesymbol
HBEGF
resolver
genesymbol_syn
DTR
resolver
genesymbol_syn
DTS
resolver
genesymbol_syn
HEGFL
resolver
hgnc
HGNC:3059
resolver
uniprot
B2R821
resolver
uniprot_entry
HBEGF_HUMAN
resolver
uniprot_sec
B2R821
resolver
amino_acid_sequence
MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNPDPPTVSTDQLLPLGGGRDRKVRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDVENEEKVKLGMTNSH
uniprot
proteins
function
FUNCTION: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
uniprot
proteins
mass_dalton
23067
uniprot
proteins
post_translational_modification
PTM: Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.; PTM: O-glycosylated with core 1 or possibly core 8 glycans. Thr-47 is a minor glycosylation site compared to Thr-44. {ECO:0000269|PubMed:1556128, ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:23234360}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1556128
uniprot
proteins
pubmed
16508205
uniprot
proteins
pubmed
1840698
uniprot
proteins
pubmed
22171320
uniprot
proteins
pubmed
23234360
uniprot
proteins
pubmed
7836353
uniprot
proteins
pubmed
9135143
uniprot
proteins
pubmed
9659904
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Heparin-binding EGF-like growth factor]: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor.; SUBCELLULAR LOCATION: [Proheparin-binding EGF-like growth factor]: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 161..184; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins