Cflar
entrez
12633
canonical
uniprot
O35732
canonical
ensembl
ENSMUSG00000026031
resolver
ensp
ENSMUSP00000065107
resolver
ensp
ENSMUSP00000109948
resolver
ensp
ENSMUSP00000109952
resolver
ensp
ENSMUSP00000277452
resolver
ensp
ENSMUSP00000277456
resolver
ensp
ENSMUSP00000277461
resolver
ensp
ENSMUSP00000277463
resolver
ensp
ENSMUSP00000277466
resolver
genesymbol
Cflar
resolver
genesymbol_syn
Cash
resolver
uniprot
D3Z0W6
resolver
uniprot
O35707
resolver
uniprot
O35733
resolver
uniprot
Q5U4G3
resolver
uniprot
Q812G4
resolver
uniprot_entry
CFLAR_MOUSE
resolver
uniprot_entry
Q5U4G3_MOUSE
resolver
uniprot_entry
Q812G4_MOUSE
resolver
uniprot_sec
D3Z0W6
resolver
uniprot_sec
O35707
resolver
uniprot_sec
O35733
resolver
amino_acid_sequence
MAQSPVSAEVIHQVEECLDEDEKEMMLFLCRDVTENLAAPNVRDLLDSLSERGQLSFATLAELLYRVRRFDLLKRILKTDKATVEDHLRRNPHLVSDYRVLLMEIGESLDQNDVSSLVFLTRDYTGRGKIAKDKSFLDLVIELEKLNLIASDQLNLLEKCLKNIHRIDLNTKIQKYTQSSQGARSNMNTLQASLPKLSIKYNSRLQNGRSKEPRFVEYRDSQRTLVKTSIQESGAFLPPHIREETYRMQSKPLGICLIIDCIGNDTKYLQETFTSLGYHIQLFLFPKSHDITQIVRRYASMAQHQDYDSFACVLVSLGGSQSMMGRDQVHSGFSLDHVKNMFTGDTCPSLRGKPKLFFIQNYESLGSQLEDSSLEVDGPSIKNVDSKPLQPRHCTTHPEADIFWSLCTADVSHLEKPSSSSSVYLQKLSQQLKQGRRRPLVDLHVELMDKVYAWNSGVSSKEKYSLSLQHTLRKKLILAPT
uniprot
proteins
function
FUNCTION: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:10602037, ECO:0000269|PubMed:10894163}.
uniprot
proteins
mass_dalton
54875
uniprot
proteins
mutagenesis
MUTAGEN 371; /note="D->A: Loss of CASP8-mediated cleavage; when associated with A-377."; /evidence="ECO:0000269|PubMed:31511692"; MUTAGEN 377; /note="D->A: Loss of CASP8-mediated cleavage; when associated with A-371."; /evidence="ECO:0000269|PubMed:31511692
uniprot
proteins
post_translational_modification
PTM: Proteolytically processed by CASP8 generating subunits p43 and p12. {ECO:0000269|PubMed:31511692}.; PTM: Deubiquitinated by USP40, leading to stabilization. {ECO:0000250|UniProtKB:O15519}.
uniprot
proteins
protein_family
Peptidase C14A family
uniprot
proteins
pubmed
10602037
uniprot
proteins
pubmed
10894163
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
31511692
uniprot
proteins
pubmed
31519887
uniprot
proteins
pubmed
9217161
uniprot
proteins
pubmed
9289491
uniprot
proteins
sequence_length
481
uniprot
proteins