ACSL6
entrez
23305
canonical
uniprot
Q9UKU0
canonical
ensembl
ENSG00000164398
resolver
ensembl
ENSG00000281938
resolver
ensp
ENSP00000296869
resolver
ensp
ENSP00000349608
resolver
ensp
ENSP00000368542
resolver
ensp
ENSP00000368546
resolver
ensp
ENSP00000368548
resolver
ensp
ENSP00000368557
resolver
ensp
ENSP00000397507
resolver
ensp
ENSP00000413329
resolver
ensp
ENSP00000442124
resolver
ensp
ENSP00000498260
resolver
ensp
ENSP00000498263
resolver
ensp
ENSP00000498444
resolver
ensp
ENSP00000498588
resolver
ensp
ENSP00000499063
resolver
ensp
ENSP00000658143
resolver
enst
ENST00000296869
resolver
enst
ENST00000434099
resolver
enst
ENST00000650697
resolver
enst
ENST00000651250
resolver
enst
ENST00000651427
resolver
genesymbol
ACSL6
resolver
genesymbol_syn
ACS2
resolver
genesymbol_syn
FACL6
resolver
genesymbol_syn
KIAA0837
resolver
genesymbol_syn
LACS5
resolver
hgnc
HGNC:16496
resolver
uniprot
A0A494BZW8
resolver
uniprot
A0A494C0B6
resolver
uniprot
A0A494C0J9
resolver
uniprot
A0A499FJL5
resolver
uniprot
B2RB13
resolver
uniprot
B4DFW3
resolver
uniprot
C9J8C7
resolver
uniprot
J3KPG3
resolver
uniprot
O94924
resolver
uniprot
O95829
resolver
uniprot
Q108M9
resolver
uniprot
Q108N0
resolver
uniprot
Q4G191
resolver
uniprot
Q86TN7
resolver
uniprot_entry
A0A494BZW8_HUMAN
resolver
uniprot_entry
A0A494C0B6_HUMAN
resolver
uniprot_entry
A0A494C0J9_HUMAN
resolver
uniprot_entry
A0A499FJL5_HUMAN
resolver
uniprot_entry
ACSL6_HUMAN
resolver
uniprot_entry
B2RB13_HUMAN
resolver
uniprot_entry
B4DFW3_HUMAN
resolver
uniprot_entry
C9J8C7_HUMAN
resolver
uniprot_sec
J3KPG3
resolver
uniprot_sec
O94924
resolver
uniprot_sec
O95829
resolver
uniprot_sec
Q108M9
resolver
uniprot_sec
Q108N0
resolver
uniprot_sec
Q4G191
resolver
uniprot_sec
Q86TN7
resolver
amino_acid_sequence
MQTQEILRILRLPELGDLGQFFRSLSATTLVSMGALAAILAYWFTHRPKALQPPCNLLMQSEEVEDSGGARRSVIGSGPQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQWLSYQEVADRAEFLGSGLLQHNCKACTDQFIGVFAQNRPEWIIVELACYTYSMVVVPLYDTLGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQKCGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHSDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5;12)(q31;p13) with ETV6. {ECO:0000269|PubMed:10502316}.; DISEASE: Note=A chromosomal aberration involving ACSL6 may be a cause of acute myelogenous leukemia with eosinophilia. Translocation t(5;12)(q31;p13) with ETV6. {ECO:0000269|PubMed:10502316}.; DISEASE: Note=A chromosomal aberration involving ACSL6 may be a cause of acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ETV6. {ECO:0000269|PubMed:10502316}.
uniprot
proteins
ec_number
6.2.1.15
uniprot
proteins
ec_number
6.2.1.3
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490, PubMed:24269233). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. {ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}.
uniprot
proteins
mass_dalton
77752
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
10502316
uniprot
proteins
pubmed
10548543
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16834775
uniprot
proteins
pubmed
22633490
uniprot
proteins
pubmed
24269233
uniprot
proteins
sequence_length
697
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24269233}; Single-pass type III membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins