D2hgdh
entrez
301624
canonical
uniprot
P84850
canonical
ensembl
ENSRNOG00000019012
resolver
ensp
ENSRNOP00000071036
resolver
enst
ENSRNOT00000078222
resolver
genesymbol
D2hgdh
resolver
uniprot
A0A8L2R544
resolver
uniprot
B2GV75
resolver
uniprot_entry
A0A8L2R544_RAT
resolver
uniprot_entry
B2GV75_RAT
resolver
uniprot_entry
D2HDH_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by zinc, cobalt and manganese ions (PubMed:15070399). Inhibited by EDTA (PubMed:15070399). {ECO:0000269|PubMed:15070399}.
uniprot
proteins
amino_acid_sequence
MVLHLVPRWSASLFRASPRWKKTYSQRASAQLKWLGCPRSVYSPLACRAYSKVSGSPEVMLTPERYPVQRLPFSTVSEEDLAAFECIIPGRVITDPEQLQTCNVDWLRTVRGCSKVLLRPQTSEEVSQILRHCYKRNLAVNPQGGNTGMVGGSVPVFDEVILSTALMNQVISFHDVSGILVCQAGCVLEELSRYVQERDFIMPLDLGAKGSCHIGGNVATNAGGLRFLRYGSLRGTVLGLEVVLADGTILNCLTSLRKDNTGYDLKQMFIGSEGTLGVITAVSIVCPPRPKAVNVAFLGCPGFTEVLQTFRTCKGQLGEILSAFEFMDAECMQLVGQHLHLTNPVQESPFYVLVETSGSSAGHDAEKLTNVLEQVLNSGLVIDGTMATDQRKVQMLWALRERITEALSRDGYVFKYDLSLPVERLYDLVIDLRTRLGPRAKHVVGYGHLGDGNLHLNVTAEAFSQELLGALEPYVYAWTAEQRGSVSAEHGLGFKKKNVLGYSKPPVAVKLMQQLKAMLDPKGILNPYKTLPARA
uniprot
proteins
ec_number
1.1.99.39
uniprot
proteins
function
FUNCTION: Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate (PubMed:15070399). Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC) (PubMed:15070399). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC (By similarity). {ECO:0000250|UniProtKB:Q8N465, ECO:0000269|PubMed:15070399}.
uniprot
proteins
mass_dalton
58805
uniprot
proteins
protein_family
FAD-binding oxidoreductase/transferase type 4 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15070399
uniprot
proteins
sequence_length
535
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:15070399}.
uniprot
proteins