Rtn3
entrez
20168
canonical
uniprot
Q9ES97
canonical
ensembl
ENSMUSG00000024758
resolver
ensp
ENSMUSP00000025667
resolver
ensp
ENSMUSP00000065810
resolver
ensp
ENSMUSP00000085494
resolver
ensp
ENSMUSP00000085496
resolver
ensp
ENSMUSP00000158024
resolver
genesymbol
Rtn3
resolver
uniprot
Q3UF62
resolver
uniprot
Q544J1
resolver
uniprot
Q68FE4
resolver
uniprot
Q6IM69
resolver
uniprot
Q6R8K6
resolver
uniprot
Q6R8K7
resolver
uniprot
Q6T929
resolver
uniprot
Q8C6D5
resolver
uniprot
Q8CCU2
resolver
uniprot_entry
RTN3_MOUSE
resolver
uniprot_sec
Q3UF62
resolver
uniprot_sec
Q544J1
resolver
uniprot_sec
Q68FE4
resolver
uniprot_sec
Q6IM69
resolver
uniprot_sec
Q6R8K6
resolver
uniprot_sec
Q6R8K7
resolver
uniprot_sec
Q6T929
resolver
uniprot_sec
Q8C6D5
resolver
uniprot_sec
Q8CCU2
resolver
amino_acid_sequence
MAESSAATQSPSVSSSSSGAEPSALGGGGGSPGACPALGAKSCGSSCADSFVSSSSSQPVSIFSTSQAGLSSLCSDEPPSKSMTSSFLSSSEIHNPDPTTPLGEKSETLGSQFVLAKGKDPLVLLDKKKLDSPQGTNKDRVDAPVSLATGIPCSHPSIPDSFPEQPAFLSKEIGPAEEWVVKDQEPKNPNKVPDGEDRSALDFGQSKAEHICTYSLSPSELPVASVEKDSPESPFEVIIDKATFDREFKDLYKENPNDLGGWAAHGDRESPADLLEMNDKLFPLRNKEAGRYPSSVLLGRQFSHTTAALEEVSRCVNDMHNFTNEILTWDLDPQAKQQANKTSCTTESTGLDRSELRSEIPVINLKTNPQQKMPVCSFNGSTPITKSTGDWTEAFTEGKPVRDYLSSTKEAGGNGVPGSSQLHSELPGSMPEKWVSGSGAATVEVTLPNLRGAWPNSVMGEVTEVDSSGESDDTVIEDITEKPDSLPSAAAKTSEREIKETPSRETVRSEMCENSEQPQAQPETPTQKSLEGEVASQVPNTLNEVTPEKLDMTNNPKVCSAAPPSVLNETGFSLTVPASAKLESLLGKYVEDTDGSSPEDLMAVLTGAEEKGIVDKEEGDVLEAVLEKIADFKNTLPVELLHESELSGSETKNIKSKYSEDSRETTGGAPTMSPDLEQEQLTIRAIKELGERQAEKVQDEGISSGGKLKQTFAPQSGPQSSSDILEHTDVKTGSDLGIPKNPTIIKNTRIDSISSLTKTEMVNKNVLARLLSDFPVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRVYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHVNKALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLVFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE
uniprot
proteins
function
FUNCTION: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress (PubMed:24262037). Induces the formation of endoplasmic reticulum tubules. Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition (By similarity). {ECO:0000250|UniProtKB:O95197, ECO:0000269|PubMed:24262037}.
uniprot
proteins
mass_dalton
103879
uniprot
proteins
pubmed
11990451
uniprot
proteins
pubmed
12832288
uniprot
proteins
pubmed
15350194
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15946766
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19665976
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24262037
uniprot
proteins
pubmed
25612671
uniprot
proteins
sequence_length
964
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15350194}; Multi-pass membrane protein {ECO:0000269|PubMed:15350194}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O95197}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins