Snx1
entrez
84471
canonical
uniprot
Q99N27
canonical
ensembl
ENSRNOG00000017029
resolver
ensembl
ENSRNOG00055025415
resolver
ensembl
ENSRNOG00060018363
resolver
ensembl
ENSRNOG00065006647
resolver
ensp
ENSRNOP00000076840
resolver
ensp
ENSRNOP00000088585
resolver
ensp
ENSRNOP00055035848
resolver
ensp
ENSRNOP00060025676
resolver
ensp
ENSRNOP00065007518
resolver
enst
ENSRNOT00000099946
resolver
enst
ENSRNOT00000110848
resolver
enst
ENSRNOT00055043863
resolver
enst
ENSRNOT00060031611
resolver
enst
ENSRNOT00065010286
resolver
genesymbol
Snx1
resolver
genesymbol_syn
LOC102549158
resolver
uniprot
A0A8I5Y518
resolver
uniprot
Q56A25
resolver
uniprot_entry
A0A8I5Y518_RAT
resolver
uniprot_entry
SNX1_RAT
resolver
uniprot_sec
Q56A25
resolver
amino_acid_sequence
MASGGGGCSASERLPPPFPGMDPESEGAAGGSEPEAGDSDTEGEDIFTGAAAASKPQSPKKTTSLFPIKNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKTMPGKTLIPHPTQEATNSPKPQPSYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPMFRSRQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQALSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTALFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKRESEARLLWANKPDKLQQAKDEITEWESRVTQYERDFERISTVVRKEVTRFEKEKSKDFKNHVIKYLETLLHSQQQLAKYWEAFLPEARAIS
uniprot
proteins
function
FUNCTION: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1). Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (By similarity). {ECO:0000250|UniProtKB:Q13596}.
uniprot
proteins
mass_dalton
59044
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
11110793
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
522
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q13596}; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q13596}. Note=Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles. Colocalized with F-actin at the leading edge of lamellipodia in a KALRN-dependent manner. {ECO:0000250|UniProtKB:Q13596}.
uniprot
proteins