Slc8a3
entrez
140448
canonical
uniprot
P70549
canonical
ensembl
ENSRNOG00000029871
resolver
ensembl
ENSRNOG00055019116
resolver
ensembl
ENSRNOG00060029848
resolver
ensembl
ENSRNOG00065017674
resolver
ensp
ENSRNOP00000041987
resolver
ensp
ENSRNOP00055026412
resolver
ensp
ENSRNOP00060043116
resolver
ensp
ENSRNOP00065023494
resolver
enst
ENSRNOT00000048606
resolver
enst
ENSRNOT00055032610
resolver
enst
ENSRNOT00060051854
resolver
enst
ENSRNOT00065029579
resolver
genesymbol
Slc8a3
resolver
genesymbol_syn
Ncx3
resolver
uniprot
A0A8L2QN54
resolver
uniprot_entry
A0A8L2QN54_RAT
resolver
uniprot_entry
NAC3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Calcium transport is down-regulated by Na(+) and stimulated by Ca(2+). {ECO:0000269|PubMed:9486131}.
uniprot
proteins
amino_acid_sequence
MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGDLRDVPSAGQNNESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFVTAAWSVFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKRYRTDKHRGIIIETEGEHPKGIEMDGKMMNSHFLDGNLIPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKTASMSEVHTDEPEDFASKVFFDPCSYQCLENCGAVLLTVVRKGGDISKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRVEEEQLEEGMTPAILNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISALLLSPEVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEEEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFVVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWAMQGQEFHVSAGTLAFSVTLFTIFAFVCLSVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYVLFATLEAYCYIKGF
uniprot
proteins
function
FUNCTION: Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:8798769, PubMed:9486131). Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Required for normal oligodendrocyte differentiation and for normal myelination. Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis. {ECO:0000250|UniProtKB:S4R2P9, ECO:0000269|PubMed:8798769, ECO:0000269|PubMed:9486131}.
uniprot
proteins
mass_dalton
103163
uniprot
proteins
protein_family
Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family
uniprot
proteins
protein_family
SLC8 subfamily
uniprot
proteins
pubmed
16914199
uniprot
proteins
pubmed
21959935
uniprot
proteins
pubmed
23506867
uniprot
proteins
pubmed
8798769
uniprot
proteins
pubmed
9486131
uniprot
proteins
sequence_length
927
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16914199, ECO:0000269|PubMed:8798769, ECO:0000269|PubMed:9486131}; Multi-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000269|PubMed:16914199}. Cell projection, dendrite {ECO:0000269|PubMed:16914199}. Cell projection, dendritic spine {ECO:0000269|PubMed:16914199}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:S4R2P9}. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:S4R2P9}. Cell junction {ECO:0000250|UniProtKB:S4R2P9}. Mitochondrion outer membrane {ECO:0000269|PubMed:16914199}; Multi-pass membrane protein {ECO:0000250|UniProtKB:S4R2P9}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16914199}; Multi-pass membrane protein {ECO:0000250|UniProtKB:S4R2P9}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P57103}. Note=Detected at neuromuscular junctions. {ECO:0000250|UniProtKB:S4R2P9}.
uniprot
proteins
transmembrane_region
TRANSMEM 74..94; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 148..168; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 231..251; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 727..747; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 755..775; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 779..799; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 829..849; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 861..881; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 904..924; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins