Tyr
entrez
22173
canonical
uniprot
P11344
canonical
ensembl
ENSMUSG00000004651
resolver
ensp
ENSMUSP00000004770
resolver
enst
ENSMUST00000004770
resolver
genesymbol
Tyr
resolver
uniprot
Q91XK0
resolver
uniprot_entry
Q91XK0_MOUSE
resolver
uniprot_entry
TYRO_MOUSE
resolver
amino_acid_sequence
MFLAVLYCLLWSFQISDGHFPRACASSKNLLAKECCPPWMGDGSPCGQLSGRGSCQDILLSSAPSGPQFPFKGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFGGPNCTEKRVLIRRNIFDLSVSEKNKFFSYLTLAKHTISSVYVIPTGTYGQMNNGSTPMFNDINIYDLFVWMHYYVSRDTLLGGSEIWRDIDFAHEAPGFLPWHRLFLLLWEQEIRELTGDENFTVPYWDWRDAENCDICTDEYLGGRHPENPNLLSPASFFSSWQIICSRSEEYNSHQVLCDGTPEGPLLRNPGNHDKAKTPRLPSSADVEFCLSLTQYESGSMDRTANFSFRNTLEGFASPLTGIADPSQSSMHNALHIFMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLLEVYPEANAPIGHNRDSYMVPFIPLYRNGDFFITSKDLGYDYSYLQESDPGFYRNYIEPYLEQASRIWPWLLGAALVGAVIAAALSGLSSRLCLQKKKKKKQPQEERQPLLMDKDDYHSLLYQSHL
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Tyr result in various forms of albinism. Himalayan strain tyrosinase is temperature-sensitive. {ECO:0000269|PubMed:2110899, ECO:0000269|PubMed:2118105, ECO:0000269|PubMed:2507645, ECO:0000269|PubMed:2567165}.
uniprot
proteins
ec_number
1.14.18.1
uniprot
proteins
function
FUNCTION: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (PubMed:2517217). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (PubMed:1537333, PubMed:2517217, PubMed:35469906). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (PubMed:1537333). {ECO:0000269|PubMed:1537333, ECO:0000269|PubMed:2517217, ECO:0000269|PubMed:35469906}.
uniprot
proteins
mass_dalton
60606
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:1537333}.
uniprot
proteins
protein_family
Tyrosinase family
uniprot
proteins
pubmed
1537333
uniprot
proteins
pubmed
2110899
uniprot
proteins
pubmed
2118105
uniprot
proteins
pubmed
2494997
uniprot
proteins
pubmed
2507645
uniprot
proteins
pubmed
2517217
uniprot
proteins
pubmed
2567165
uniprot
proteins
pubmed
26620560
uniprot
proteins
pubmed
3134020
uniprot
proteins
pubmed
3141148
uniprot
proteins
pubmed
35469906
uniprot
proteins
sequence_length
533
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000250|UniProtKB:P14679}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P14679}. Melanosome {ECO:0000269|PubMed:26620560}. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000269|PubMed:26620560}.
uniprot
proteins
transmembrane_region
TRANSMEM 477..497; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins