SLC30A10
entrez
55532
canonical
uniprot
Q6XR72
canonical
ensembl
ENSG00000196660
resolver
ensp
ENSP00000355893
resolver
ensp
ENSP00000512752
resolver
enst
ENST00000696608
resolver
genesymbol
SLC30A10
resolver
genesymbol_syn
ZNT10
resolver
genesymbol_syn
ZNT8
resolver
hgnc
HGNC:25355
resolver
uniprot
A0A8Q3WLF3
resolver
uniprot
B3KR19
resolver
uniprot
D3DTA8
resolver
uniprot
Q49AL9
resolver
uniprot
Q9NPW0
resolver
uniprot_entry
A0A8Q3WLF3_HUMAN
resolver
uniprot_entry
B3KR19_HUMAN
resolver
uniprot_entry
ZNT10_HUMAN
resolver
uniprot_sec
D3DTA8
resolver
uniprot_sec
Q49AL9
resolver
uniprot_sec
Q9NPW0
resolver
amino_acid_sequence
MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLSAGYIARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGPQGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQCYIDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQDASTKIREIFHHAGIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQSLNKTQEDQCYVNRTHF
uniprot
proteins
disease_involvement
DISEASE: Hypermanganesemia with dystonia 1 (HMNDYT1) [MIM:613280]: A metabolic autosomal recessive disorder characterized by dystonia, parkinsonism, extrapyramidal signs, severe hypermanganesemia, polycythemia, and chronic hepatic disease, including steatosis and cirrhosis. {ECO:0000269|PubMed:22341971, ECO:0000269|PubMed:22341972, ECO:0000269|PubMed:25319704}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange (PubMed:30755481). Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis (PubMed:22341972, PubMed:25319704, PubMed:26728129, PubMed:27226609, PubMed:27307044). Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes (PubMed:22427991, PubMed:26728129). {ECO:0000269|PubMed:22341972, ECO:0000269|PubMed:22427991, ECO:0000269|PubMed:25319704, ECO:0000269|PubMed:26728129, ECO:0000269|PubMed:27226609, ECO:0000269|PubMed:27307044, ECO:0000269|PubMed:30755481}.
uniprot
proteins
mass_dalton
52684
uniprot
proteins
mutagenesis
MUTAGEN 4; /note="Y->F: Decreased interaction with SLC30A3. No effect on self-association. Decreased zinc ion transmembrane transporter activity. Decreased EGF-induced ERK1/2 phosphorylation."; /evidence="ECO:0000269|PubMed:26728129"; MUTAGEN 25; /note="E->A: No effect on localization to the plasma membrane. Loss of calcium:manganese antiporter activity."; /evidence="ECO:0000269|PubMed:27307044"; MUTAGEN 40; /note="D->A: No effect on localization to the plasma membrane. Loss of calcium:manganese antiporter activity."; /evidence="ECO:0000269|PubMed:27307044"; MUTAGEN 43; /note="N->A: No effect on localization to the plasma membrane. Changed calcium:manganese antiporter activity. Enhanced coupling between manganese and calcium exchange."; /evidence="ECO:0000269|PubMed:27307044, ECO:0000269|PubMed:30755481"; MUTAGEN 43; /note="N->D: Loss of calcium:manganese antiporter activity."; /evidence="ECO:0000269|PubMed:30755481"; MUTAGEN 43; /note="N->H: No effect on localization to the plasma membrane. Loss of calcium:manganese antiporter activity. Loss of calcium:manganese antiporter activity and increased zinc ion transmembrane transporter activity; when associated with V-52 and F-242."; /evidence="ECO:0000269|PubMed:27226609, ECO:0000269|PubMed:30755481"; MUTAGEN 43; /note="N->T: Loss of calcium:manganese antiporter activity. Uncoupling between manganese and calcium exchange."; /evidence="ECO:0000269|PubMed:30755481"; MUTAGEN 47; /note="D->A: No effect on localization to the plasma membrane. No effect on calcium:manganese antiporter activity."; /evidence="ECO:0000269|PubMed:27307044"; MUTAGEN 47; /note="D->E: Loss of calcium:manganese antiporter activity."; /evidence="ECO:0000269|PubMed:30755481"; MUTAGEN 52; /note="C->V: Loss of calcium:manganese antiporter activity and increased zinc ion transmembrane transporter activity; when associated with H-43 and F-242."; /evidence="ECO:0000269|PubMed:27226609"; MUTAGEN 127; /note="N->A: No effect on localization to the plasma membrane. No effect on localization to the plasma membrane and decreased calcium:manganese antiporter activity; when associated with A-244."; /evidence="ECO:0000269|PubMed:27307044"; MUTAGEN 196; /note="T->P: Loss of localization to the plasma membrane."; /evidence="ECO:0000269|PubMed:25319704"; MUTAGEN 242; /note="L->F: Loss of calcium:manganese antiporter activity and increased zinc ion transmembrane transporter activity; when associated with H-43 and V-52."; /evidence="ECO:0000269|PubMed:27226609"; MUTAGEN 244; /note="H->A: No effect on localization to the plasma membrane. No effect on localization to the plasma membrane and decreased calcium:manganese antiporter activity; when associated with A-127."; /evidence="ECO:0000269|PubMed:27307044"; MUTAGEN 244; /note="H->D: Loss of calcium:manganese antiporter activity."; /evidence="ECO:0000269|PubMed:30755481"; MUTAGEN 248; /note="D->A: No effect on localization to the plasma membrane. Loss of manganese ion export across plasma membrane."; /evidence="ECO:0000269|PubMed:27307044"; MUTAGEN 333; /note="H->A: Decreased calcium:manganese antiporter activity."; /evidence="ECO:0000269|PubMed:27307044"; MUTAGEN 350; /note="H->A: Decreased calcium:manganese antiporter activity."; /evidence="ECO:0000269|PubMed:27307044
uniprot
proteins
protein_family
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
uniprot
proteins
protein_family
SLC30A subfamily
uniprot
proteins
pubmed
15154973
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
22341971
uniprot
proteins
pubmed
22341972
uniprot
proteins
pubmed
22427991
uniprot
proteins
pubmed
22706290
uniprot
proteins
pubmed
25319704
uniprot
proteins
pubmed
25582195
uniprot
proteins
pubmed
26728129
uniprot
proteins
pubmed
27226609
uniprot
proteins
pubmed
27307044
uniprot
proteins
pubmed
30755481
uniprot
proteins
sequence_length
485
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22706290, ECO:0000269|PubMed:25319704, ECO:0000269|PubMed:26728129, ECO:0000269|PubMed:27226609, ECO:0000269|PubMed:27307044}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:22706290, ECO:0000269|PubMed:27226609}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:22427991, ECO:0000269|PubMed:26728129}. Early endosome membrane {ECO:0000269|PubMed:22427991, ECO:0000269|PubMed:26728129}; Multi-pass membrane protein {ECO:0000255}. Note=Localization to the Golgi and plasma membrane is regulated by zinc. {ECO:0000269|PubMed:22706290}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 41..61; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 245..265; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 279..299; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins