P51794
uniprot
P51794
canonical
amino_acid_sequence
MDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEFIKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCPLWQKWSELLLSQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTVFTRCNIAWCRRRKTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVITIFTFGMKIPSGLFIPSMAVGAMAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKNARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIIFN
uniprot
proteins
function
FUNCTION: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P51793}.
uniprot
proteins
mass_dalton
83701
uniprot
proteins
protein_family
Chloride channel (TC 2.A.49) family
uniprot
proteins
protein_family
ClC-4/CLCN4 subfamily
uniprot
proteins
pubmed
16222710
uniprot
proteins
pubmed
7730971
uniprot
proteins
sequence_length
747
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:16222710}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:16222710}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P51793}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:P51793}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000250|UniProtKB:P51793}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to late endosome membrane, lysosome membrane and recycling endosome membrane in the presence of CLCN3. {ECO:0000250|UniProtKB:P51793}.
uniprot
proteins
transmembrane_region
TRANSMEM 55..92; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 138..161; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 187..205; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 211..230; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 278..296; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 320..345; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 352..372; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 429..449; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 454..473; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 535..553; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523
uniprot
proteins