Kansl3
entrez
226976
canonical
uniprot
A2RSY1
canonical
ensembl
ENSMUSG00000010453
resolver
ensp
ENSMUSP00000010597
resolver
ensp
ENSMUSP00000140547
resolver
ensp
ENSMUSP00000140597
resolver
ensp
ENSMUSP00000246192
resolver
genesymbol
Kansl3
resolver
genesymbol_syn
Kiaa1310
resolver
genesymbol_syn
Nsl3
resolver
uniprot
Q6ZPU0
resolver
uniprot
Q8C0P9
resolver
uniprot_entry
KANL3_MOUSE
resolver
uniprot_sec
Q6ZPU0
resolver
uniprot_sec
Q8C0P9
resolver
amino_acid_sequence
MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRMLFVTPRRQQENTIESDVPIDVETVTATPVPLYDNQKARSVMNECERHVIFARTDADAPPPPEDWEEHVNRTGWTVAQNKLFNKILKALQSDRLARLANEGACNEPVLRRVAVDKCARRVRQALASVSWDTKLTQWLHTTLVETLSLPMLAAYLDALQTLKGKIPTLIDRMLVSSNTKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIVSSGPSSSVFPASRRHRFWQSQLSCLGKVIPVATHLLNNGSGVGVLQCLEHMIGAVRSKVLEIHSHFPHKPIILIGWNTGALVACHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDPLLDMKTPVLFVIGQNSLQCHPEAMEDFREKIRAENSLVVVGGADDNLRISKAKKKSEGLTQSMVDRCIQDEIVDFLTGVLTRAEGHVGSEPRDQDAEKKKKPRDLTRRDLAFEIPERGSRPASPAARLPTSPSGSEDLSSVSSSPTSSPKTKVTTVTSTQKSSQIGTSQLLKRHVQRTEAVLTHRQAQAQFAAFLKQNMLVRKAFPPGTSSCLFVPISSESVEDIEKEELRVQLKRHHSSSPLPGAKPSKRPKIKVSLISQGDTVGGPCTLSQGGTPEAAGGKPITMTLGASAGAKELTGLLTTAKSSSSEGGGTASTTPSVASSSATPNAIHTLQSRLVATSPGSSLPGTASASSLLQGLSFSLQDISSKTSGLPGSPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLGATPGGKPTAIHQLLTNGSLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGATPSEEPNSQMLPSSSQRLPPAP
uniprot
proteins
function
FUNCTION: Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (By similarity). The NSL complex also acts as a regulator of gene expression in mitochondria (By similarity). Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA (By similarity). Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells (PubMed:37624894). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (PubMed:37624894). Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (PubMed:31576060). Plays an essential role in spindle assembly during mitosis (By similarity). Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly (By similarity). Indispensable during early embryonic development where it is required for proper lineage specification and maintenance during peri-implantation development and is essential for implantation (PubMed:38769918). {ECO:0000250|UniProtKB:Q9P2N6, ECO:0000269|PubMed:31576060, ECO:0000269|PubMed:37624894, ECO:0000269|PubMed:38769918}.
uniprot
proteins
mass_dalton
96135
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24842875
uniprot
proteins
pubmed
31576060
uniprot
proteins
pubmed
37624894
uniprot
proteins
pubmed
38769918
uniprot
proteins
sequence_length
903
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9P2N6}. Mitochondrion {ECO:0000250|UniProtKB:Q9P2N6}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9P2N6}. Note=Concentrated in the nucleus during interphase but displays a marked relocalization to the spindle poles during mitosis. {ECO:0000250|UniProtKB:Q9P2N6}.
uniprot
proteins