TBC1D10A
entrez
83874
canonical
uniprot
Q9BXI6
canonical
ensembl
ENSG00000099992
resolver
ensp
ENSP00000215790
resolver
ensp
ENSP00000384996
resolver
genesymbol
TBC1D10A
resolver
genesymbol_syn
EPI64
resolver
genesymbol_syn
TBC1D10
resolver
hgnc
HGNC:23609
resolver
uniprot
A7E244
resolver
uniprot
B3KXT8
resolver
uniprot
B7ZVY9
resolver
uniprot
O76053
resolver
uniprot
Q20WK7
resolver
uniprot
Q543A2
resolver
uniprot_entry
A7E244_HUMAN
resolver
uniprot_entry
B7ZVY9_HUMAN
resolver
uniprot_entry
TB10A_HUMAN
resolver
uniprot_sec
B3KXT8
resolver
uniprot_sec
O76053
resolver
uniprot_sec
Q20WK7
resolver
uniprot_sec
Q543A2
resolver
amino_acid_sequence
MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLPLDAPLPGSKAKPKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKDSAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811). {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:30905672}.
uniprot
proteins
mass_dalton
57118
uniprot
proteins
mutagenesis
MUTAGEN 157; /note="D->A: Loss of activity. No effect on subcellular location."; /evidence="ECO:0000269|PubMed:16923811"; MUTAGEN 160; /note="R->K: Loss of activity. No effect on subcellular location."; /evidence="ECO:0000269|PubMed:16923811"; MUTAGEN 508; /note="L->LA: Loss of interaction with EBP50 and impaired subcellular localization."; /evidence="ECO:0000269|PubMed:11285285
uniprot
proteins
post_translational_modification
PTM: Exists in both phosphorylated and non-phosphorylated state.
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11285285
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16923811
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19077034
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30905672
uniprot
proteins
sequence_length
508
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, microvillus {ECO:0000269|PubMed:16923811}. Note=Localizes to the microvilli-rich region of the syncytiotrophoblast. In melanocytes, located at the periphery of cells.
uniprot
proteins