Sin3b
entrez
20467
canonical
uniprot
Q62141
canonical
ensembl
ENSMUSG00000031622
resolver
ensp
ENSMUSP00000004494
resolver
ensp
ENSMUSP00000105576
resolver
genesymbol
Sin3b
resolver
genesymbol_syn
Kiaa0700
resolver
uniprot
O54976
resolver
uniprot
Q3TN09
resolver
uniprot
Q6A013
resolver
uniprot
Q8VCB8
resolver
uniprot
Q8VDZ5
resolver
uniprot_entry
Q3TN09_MOUSE
resolver
uniprot_entry
SIN3B_MOUSE
resolver
uniprot_sec
O54976
resolver
uniprot_sec
Q6A013
resolver
uniprot_sec
Q8VCB8
resolver
uniprot_sec
Q8VDZ5
resolver
amino_acid_sequence
MAHAGSGGSAGRGFGGSRWGRSGSGGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLFHEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLSSQDNSHSHGDCGEDFKQMSYKEDRGQVPLESDSVEFNNAISYVNKIKTRFLDHPEIYRSFLEILHTYQKEQLHTKGRPFRGMSEEEVFTEVANLFRGQEDLLSEFGQFLPEAKRSLFTGNGSCEMNSGQKNEEKSLEHNKKRSRPSLLRPVSAPAKKKMKLRGTKDLSIAAVGKYGTLQEFSFFDKVRRVLKSQEVYENFLRCIALFNQELVSGSELLQLVSPFLGKFPELFAQFKSFLGVKELSFAPPMSDRSGDGISREIDYASCKRIGSSYRALPKTYQQPKCSGRTAICKEVLNDTWVSFPSWSEDSTFVSSKKTPYEEQLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMAPEDQEKLRLDDCLGGTSEVIQRRAIHRIYGDKAPEVIESLKRNPATAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQAVNFKQNDTKALRSKSLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYEDRQILEDAAALISYYVKRQPAIQKEDQGTIRQLLHRFLPSLFFSQQCPGTSDDSADERDRDRDSAEPERRRPTDEKPPADASPEPPKVLDDVYSLFFANNNWYFFLRLHQTLCARLLKIYRQAQKQLLEHRREQEREQLLCEGRREKAADPAMELRLKQPSEVELEEYYPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYIGFTMDKLVQNIARQLHHLVSDDVCLKVVELYLNEQQRGAAGGNLSSRCVRAARETSYQWKAERCMADENCFKVMFLQRRGQVIMTIELLDTEEAQTEDPVEVQHLARYVEQYVGSEGASSSSTEGFLLKPVFLQRNLKKFRRWQCEQVRAMRGEAKSSWKRLMGVESACDVDCRFRLGTHKMVFIVNSEDYMYRRGTLCRAKQVQPLVLLRHHRHFEEWHGRWLEDNVTVAAAGLVQDWLMGEEEEDMVPCKTLCETAHVHGLPVTRYRVQYSRRPASP
uniprot
proteins
function
FUNCTION: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression (PubMed:22476904). As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (By similarity). {ECO:0000250|UniProtKB:O75182, ECO:0000269|PubMed:10620510, ECO:0000269|PubMed:22476904, ECO:0000269|PubMed:7889570}.
uniprot
proteins
mass_dalton
126405
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by RNF220 that leads to proteasomal degradation. {ECO:0000269|PubMed:20170641}.
uniprot
proteins
pubmed
10620510
uniprot
proteins
pubmed
11101889
uniprot
proteins
pubmed
11909966
uniprot
proteins
pubmed
12398767
uniprot
proteins
pubmed
15226430
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16288918
uniprot
proteins
pubmed
16787967
uniprot
proteins
pubmed
20170641
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22476904
uniprot
proteins
pubmed
28379941
uniprot
proteins
pubmed
7889570
uniprot
proteins
pubmed
8521822
uniprot
proteins
pubmed
8617250
uniprot
proteins
pubmed
9139820
uniprot
proteins
pubmed
9702189
uniprot
proteins
sequence_length
1098
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00810, ECO:0000269|PubMed:20170641, ECO:0000269|PubMed:7889570}.
uniprot
proteins