ANLN
entrez
54443
canonical
uniprot
Q9NQW6
canonical
ensembl
ENSG00000011426
resolver
ensp
ENSP00000265748
resolver
ensp
ENSP00000379380
resolver
ensp
ENSP00000523961
resolver
ensp
ENSP00000588562
resolver
ensp
ENSP00000588563
resolver
ensp
ENSP00000588564
resolver
ensp
ENSP00000588565
resolver
genesymbol
ANLN
resolver
hgnc
HGNC:14082
resolver
uniprot
A8K5D9
resolver
uniprot
Q5CZ78
resolver
uniprot
Q6NSK5
resolver
uniprot
Q9H8Y4
resolver
uniprot
Q9NVN9
resolver
uniprot
Q9NVP0
resolver
uniprot_entry
A8K5D9_HUMAN
resolver
uniprot_entry
ANLN_HUMAN
resolver
uniprot_sec
Q5CZ78
resolver
uniprot_sec
Q6NSK5
resolver
uniprot_sec
Q9H8Y4
resolver
uniprot_sec
Q9NVN9
resolver
uniprot_sec
Q9NVP0
resolver
amino_acid_sequence
MDPFTEKLLERTRARRENLQRKMAERPTAAPRSMTHAKRARQPLSEASNQQPLSGGEEKSCTKPSPSKKRCSDNTEVEVSNLENKQPVESTSAKSCSPSPVSPQVQPQAADTISDSVAVPASLLGMRRGLNSRLEATAASSVKTRMQKLAEQRRRWDNDDMTDDIPESSLFSPMPSEEKAASPPRPLLSNASATPVGRRGRLANLAATICSWEDDVNHSFAKQNSVQEQPGTACLSKFSSASGASARINSSSVKQEATFCSQRDGDASLNKALSSSADDASLVNASISSSVKATSPVKSTTSITDAKSCEGQNPELLPKTPISPLKTGVSKPIVKSTLSQTVPSKGELSREICLQSQSKDKSTTPGGTGIKPFLERFGERCQEHSKESPARSTPHRTPIITPNTKAIQERLFKQDTSSSTTHLAQQLKQERQKELACLRGRFDKGNIWSAEKGGNSKSKQLETKQETHCQSTPLKKHQGVSKTQSLPVTEKVTENQIPAKNSSTEPKGFTECEMTKSSPLKITLFLEEDKSLKVTSDPKVEQKIEVIREIEMSVDDDDINSSKVINDLFSDVLEEGELDMEKSQEEMDQALAESSEEQEDALNISSMSLLAPLAQTVGVVSPESLVSTPRLELKDTSRSDESPKPGKFQRTRVPRAESGDSLGSEDRDLLYSIDAYRSQRFKETERPSIKQVIVRKEDVTSKLDEKNNAFPCQVNIKQKMQELNNEINMQQTVIYQASQALNCCVDEEHGKGSLEEAEAERLLLIATGKRTLLIDELNKLKNEGPQRKNKASPQSEFMPSKGSVTLSEIRLPLKADFVCSTVQKPDAANYYYLIILKAGAENMVATPLASTSNSLNGDALTFTTTFTLQDVSNDFEINIEVYSLVQKKDPSGLDKKKKTSKSKAITPKRLLTSITTKSNIHSSVMASPGGLSAVRTSNFALVGSYTLSLSSVGNTKFVLDKVPFLSSLEGHIYLKIKCQVNSSVEERGFLTIFEDVSGFGAWHRRWCVLSGNCISYWTYPDDEKRKNPIGRINLANCTSRQIEPANREFCARRNTFELITVRPQREDDRETLVSQCRDTLCVTKNWLSADTKEERDLWMQKLNQVLVDIRLWQPDACYKPIGKP
uniprot
proteins
disease_involvement
DISEASE: Focal segmental glomerulosclerosis 8 (FSGS8) [MIM:616032]: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. {ECO:0000269|PubMed:24676636}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.
uniprot
proteins
mass_dalton
124199
uniprot
proteins
mutagenesis
MUTAGEN 32; /note="R->A: Abrogates interaction with CD2AP."; /evidence="ECO:0000269|PubMed:15800069"; MUTAGEN 41; /note="R->A: Abrogates ubiquitin-mediated proteolysis; when associated with A-44."; /evidence="ECO:0000269|PubMed:16040610"; MUTAGEN 44; /note="L->A: Abrogates ubiquitin-mediated proteolysis; when associated with A-41."; /evidence="ECO:0000269|PubMed:16040610
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during mitosis. {ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:16357138}.; PTM: Ubiquitinated, and this requires FZR1/CDH1. {ECO:0000269|PubMed:16040610}.
uniprot
proteins
pubmed
10931866
uniprot
proteins
pubmed
12479805
uniprot
proteins
pubmed
12637748
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15496454
uniprot
proteins
pubmed
15616196
uniprot
proteins
pubmed
15800069
uniprot
proteins
pubmed
16040610
uniprot
proteins
pubmed
16129829
uniprot
proteins
pubmed
16203764
uniprot
proteins
pubmed
16357138
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23870127
uniprot
proteins
pubmed
24676636
uniprot
proteins
pubmed
25114211
uniprot
proteins
sequence_length
1124
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex {ECO:0000269|PubMed:23870127}. Cell projection, bleb {ECO:0000269|PubMed:23870127}. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.
uniprot
proteins