Rb1cc1
entrez
12421
canonical
uniprot
Q9ESK9
canonical
ensembl
ENSMUSG00000025907
resolver
ensp
ENSMUSP00000027040
resolver
ensp
ENSMUSP00000274649
resolver
ensp
ENSMUSP00000274655
resolver
ensp
ENSMUSP00000274656
resolver
ensp
ENSMUSP00000274659
resolver
enst
ENSMUST00000027040
resolver
genesymbol
Rb1cc1
resolver
genesymbol_syn
Cc1
resolver
genesymbol_syn
Kiaa0203
resolver
uniprot
E9QLQ2
resolver
uniprot
Q3TXX2
resolver
uniprot
Q61384
resolver
uniprot
Q8BRY9
resolver
uniprot
Q9JK14
resolver
uniprot_entry
RBCC1_MOUSE
resolver
uniprot_sec
E9QLQ2
resolver
uniprot_sec
Q3TXX2
resolver
uniprot_sec
Q61384
resolver
uniprot_sec
Q8BRY9
resolver
uniprot_sec
Q9JK14
resolver
amino_acid_sequence
MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRAPAIPKATFSTENDMEIKVEESLMMPAVFHTVASRTQLAVEMYDVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSDYLQSIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRPDSLNEHEGSEKAEMKRSTELVLSPDMPRTTNTSLVTSFHKSMEHVAPDPTGTERGKELRESCQSTVQQEEASVDAKDSDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPKIIQPFMLECHQTIAKLDNQNMKAIKGLEDRLYALDQMIASCSRLVNEQKELAQGFLANQMRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHVRLKWCCFVMLHADQDGEKLQALLRLVIELLERVRIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKQLYEAEKSKRESFGKLFRKSFLRNRLFKGLDSWPSSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQTITDLLNEQKVSTSQASPQSAASPRIESTTGITTTTSPKTPPPLTVQDTLCPAVCPLEELSPDSIDAHTFDFETISHPNTEQPVHQASIDLDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDTSTRGNEGFGDRAALHVQLEKCRAAAQDSHSSIQTIKDDLCHFRTFVQKEQCDLANYLKCTAVEIRNIIEKVKCSLEITLKEKHQQELQSLKIEYECKLDALVKDSEENVNKILKLKENLVSLEEALQNKDNEFTSIKHEKDAIVCVQQEKDQKLLEMEKIMHTQHCEIKELKQSREMALEDLKKLHDEKIESLRAEFQCLEQNHLKELEDTLHIRHTQEFEKVMTDHNMSLEKLKKENQQRIDQMLESHASTIQEKEQQLQELKLKVSDLSDMRCKLEVELALKEAETDEIKILLEESRTQQKEMLKSLLEQETENLRTEISKLNQKIHDNNESYQVGLSELRALMTIEKDQCISELISRHEEESNILKAELDNVTSLHRQAYEIEKKLKEQIVELQTRLNSELSALEKQKDEKITQQEEKYEALIQNLEKDKERLVKNHEQDKEHLIQELNFEKNKAVQTALDEFKVERELVEKELLEKVKHLENQIAKTPAFESAREDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKQLEEEVSKLRTSSFLSSAPVAAAPELYGACAPELPGEPERSVMETADEGRLDSAMETSMMSVQENMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSLSSVSSRHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESLPALDLKPGEGASGASRRPWVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVKAVSWNKKV
uniprot
proteins
function
FUNCTION: Involved in autophagy (PubMed:19258318, PubMed:23262492). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:19258318, PubMed:23285000, PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (PubMed:21525242). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (PubMed:21807966). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (By similarity). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (PubMed:21795712). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:15968549). Plays a crucial role in muscular differentiation (PubMed:15968549). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (PubMed:19940130, PubMed:21088496). {ECO:0000250|UniProtKB:Q8TDY2, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:15968549, ECO:0000269|PubMed:19258318, ECO:0000269|PubMed:19940130, ECO:0000269|PubMed:21088496, ECO:0000269|PubMed:21525242, ECO:0000269|PubMed:21795712, ECO:0000269|PubMed:21807966, ECO:0000269|PubMed:23262492, ECO:0000269|PubMed:23285000, ECO:0000269|PubMed:23392225}.
uniprot
proteins
mass_dalton
182350
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-733 of the FFAT motif activates interaction with MOSPD2. {ECO:0000250|UniProtKB:Q8TDY2}.
uniprot
proteins
pubmed
11207567
uniprot
proteins
pubmed
12095676
uniprot
proteins
pubmed
15375585
uniprot
proteins
pubmed
15968549
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19258318
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19940130
uniprot
proteins
pubmed
21088496
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21525242
uniprot
proteins
pubmed
21795712
uniprot
proteins
pubmed
21807966
uniprot
proteins
pubmed
23262492
uniprot
proteins
pubmed
23285000
uniprot
proteins
pubmed
23392225
uniprot
proteins
pubmed
28561066
uniprot
proteins
pubmed
7724523
uniprot
proteins
sequence_length
1588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12095676}. Cytoplasm, cytosol {ECO:0000269|PubMed:19258318}. Cytoplasm {ECO:0000250|UniProtKB:Q8TDY2}. Preautophagosomal structure {ECO:0000269|PubMed:19258318}. Lysosome {ECO:0000250|UniProtKB:Q8TDY2}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000269|PubMed:19258318}.
uniprot
proteins