PAX5
entrez
5079
canonical
uniprot
Q02548
canonical
ensembl
ENSG00000196092
resolver
ensp
ENSP00000350844
resolver
ensp
ENSP00000367078
resolver
ensp
ENSP00000367083
resolver
ensp
ENSP00000367084
resolver
ensp
ENSP00000404687
resolver
ensp
ENSP00000412188
resolver
ensp
ENSP00000429197
resolver
ensp
ENSP00000429291
resolver
ensp
ENSP00000429359
resolver
ensp
ENSP00000429637
resolver
ensp
ENSP00000430773
resolver
ensp
ENSP00000498443
resolver
enst
ENST00000520154
resolver
enst
ENST00000522003
resolver
enst
ENST00000523145
resolver
enst
ENST00000523241
resolver
enst
ENST00000651550
resolver
genesymbol
PAX5
resolver
hgnc
HGNC:8619
resolver
uniprot
A3QVP6
resolver
uniprot
A3QVP7
resolver
uniprot
A3QVP8
resolver
uniprot
C0KTE5
resolver
uniprot
C0KTF5
resolver
uniprot
C0KTF6
resolver
uniprot
C0KTF7
resolver
uniprot
C0KTF8
resolver
uniprot
C0KTF9
resolver
uniprot
C0KTG0
resolver
uniprot
E7EQT0
resolver
uniprot
E7ERK2
resolver
uniprot
E7ERW5
resolver
uniprot
E7ES87
resolver
uniprot
O75933
resolver
uniprot
Q5SFM2
resolver
uniprot
Q6S728
resolver
uniprot
Q6S729
resolver
uniprot
Q6S730
resolver
uniprot
Q6S731
resolver
uniprot
Q6S732
resolver
uniprot_entry
C0KTE5_HUMAN
resolver
uniprot_entry
C0KTF5_HUMAN
resolver
uniprot_entry
E7EQT0_HUMAN
resolver
uniprot_entry
E7ERK2_HUMAN
resolver
uniprot_entry
E7ERW5_HUMAN
resolver
uniprot_entry
E7ES87_HUMAN
resolver
uniprot_entry
PAX5_HUMAN
resolver
uniprot_sec
A3QVP6
resolver
uniprot_sec
A3QVP7
resolver
uniprot_sec
A3QVP8
resolver
uniprot_sec
C0KTF6
resolver
uniprot_sec
C0KTF7
resolver
uniprot_sec
C0KTF8
resolver
uniprot_sec
C0KTF9
resolver
uniprot_sec
C0KTG0
resolver
uniprot_sec
O75933
resolver
uniprot_sec
Q5SFM2
resolver
uniprot_sec
Q6S728
resolver
uniprot_sec
Q6S729
resolver
uniprot_sec
Q6S730
resolver
uniprot_sec
Q6S731
resolver
uniprot_sec
Q6S732
resolver
amino_acid_sequence
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARGAAPPAAATAYDRH
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6. {ECO:0000269|PubMed:17344859}.; DISEASE: Leukemia, acute lymphoblastic, 3 (ALL3) [MIM:613065]: A subtype of acute leukemia, a cancer of the white blood cells. Acute lymphoblastic anemia is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphnodes. {ECO:0000269|PubMed:24013638}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238). {ECO:0000269|PubMed:10811620, ECO:0000269|PubMed:27181361, ECO:0000269|PubMed:32612238}.; FUNCTION: (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription (PubMed:31941781). Also participates in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity (PubMed:23678172). {ECO:0000269|PubMed:23678172, ECO:0000269|PubMed:31941781}.
uniprot
proteins
mass_dalton
42149
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000305}.; PTM: Phosphorylated by SYK. This phosphorylation plays an important role in the abolition of BLIMP1 repression by PAX5 in order to trigger plasma cell differentiation. {ECO:0000269|PubMed:27181361}.
uniprot
proteins
pubmed
10197586
uniprot
proteins
pubmed
10811620
uniprot
proteins
pubmed
11779502
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
1516825
uniprot
proteins
pubmed
15385562
uniprot
proteins
pubmed
17344859
uniprot
proteins
pubmed
19725825
uniprot
proteins
pubmed
23678172
uniprot
proteins
pubmed
24013638
uniprot
proteins
pubmed
27181361
uniprot
proteins
pubmed
31941781
uniprot
proteins
pubmed
32612238
uniprot
proteins
pubmed
9742255
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31941781}.
uniprot
proteins