Kctd11
entrez
216858
canonical
uniprot
Q8K485
canonical
ensembl
ENSMUSG00000046731
resolver
ensp
ENSMUSP00000059107
resolver
ensp
ENSMUSP00000159163
resolver
enst
ENSMUST00000050555
resolver
enst
ENSMUST00000238978
resolver
genesymbol
Kctd11
resolver
genesymbol_syn
Ren
resolver
uniprot
A0A5K1VVR8
resolver
uniprot_entry
A0A5K1VVR8_MOUSE
resolver
uniprot_entry
KCD11_MOUSE
resolver
amino_acid_sequence
MLGAMFRADTLMPANLNPQGDGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALLKAEADFYQIRPLLDALRELEASRGTPASTAALLHADVDVSPRQVHFSARRGPHHYELSSVQVDTFRANLFCTDPECLAAMRNRFGVAIGDRAEGGPHFRLEWASRPQELPEVEYQRLGLQPLWTGGPEDRREVANTPTFLEEVLRVALEHGFRLDSVFPDPEDLLNSRSLRFVRH
uniprot
proteins
function
FUNCTION: Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. {ECO:0000250|UniProtKB:Q693B1, ECO:0000269|PubMed:12186855, ECO:0000269|PubMed:16148242}.
uniprot
proteins
mass_dalton
26300
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
12186855
uniprot
proteins
pubmed
15249678
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16148242
uniprot
proteins
sequence_length
232
uniprot
proteins