IL2RB
entrez
3560
canonical
uniprot
P14784
canonical
ensembl
ENSG00000100385
resolver
ensp
ENSP00000216223
resolver
ensp
ENSP00000401020
resolver
ensp
ENSP00000402685
resolver
ensp
ENSP00000403731
resolver
ensp
ENSP00000514005
resolver
ensp
ENSP00000514009
resolver
ensp
ENSP00000514011
resolver
ensp
ENSP00000514012
resolver
ensp
ENSP00000528200
resolver
ensp
ENSP00000528201
resolver
ensp
ENSP00000528203
resolver
enst
ENST00000216223
resolver
enst
ENST00000429622
resolver
enst
ENST00000445595
resolver
enst
ENST00000453962
resolver
enst
ENST00000698883
resolver
enst
ENST00000698890
resolver
enst
ENST00000698892
resolver
enst
ENST00000698893
resolver
enst
ENST00000858141
resolver
enst
ENST00000858142
resolver
enst
ENST00000858144
resolver
genesymbol
IL2RB
resolver
genesymbol_syn
IL15RB
resolver
hgnc
HGNC:6009
resolver
uniprot
B2R765
resolver
uniprot_entry
IL2RB_HUMAN
resolver
uniprot_sec
B2R765
resolver
amino_acid_sequence
MAAPALSWRLPLLILLLPLATSWASAAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTIPWLGHLLVGLSGAFGFIILVYLLINCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLLLQQDKVPEPASLSSNHSLTSCFTNQGYFFFHLPDALEIEACQVYFTYDPYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRDDLLLFSPSLLGGPSPPSTAPGGSGAGEERMPPSLQERVPRDWDPQPLGPPTPGVPDLVDFQPPPELVLREAGEEVPDAGPREGVSFPWSRPPGQGEFRALNARLPLNTDAYLSLQELQGQDPTHLV
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 63 with lymphoproliferation and autoimmunity (IMD63) [MIM:618495]: An autosomal recessive disorder characterized by immune dysregulation resulting in lymphoid proliferation, dermatitis, enteropathy, autoantibodies, hypergammaglobulinemia, and immunodeficiency with recurrent infections. Patients show increased susceptibility to viral infections, particularly cytomegalovirus disease. {ECO:0000269|PubMed:31040184, ECO:0000269|PubMed:31040185}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770, PubMed:31040185). {ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:31040184, ECO:0000269|PubMed:31040185}.
uniprot
proteins
mass_dalton
61117
uniprot
proteins
mutagenesis
MUTAGEN 418; /note="Y->F: Partial loss of interaction with SHB; when associated with F-536."; /evidence="ECO:0000269|PubMed:12200137"; MUTAGEN 536; /note="Y->F: Partial loss of interaction with SHB; when associated with F-418."; /evidence="ECO:0000269|PubMed:12200137
uniprot
proteins
protein_family
Type 4 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12200137
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15123770
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16293754
uniprot
proteins
pubmed
16477002
uniprot
proteins
pubmed
2785715
uniprot
proteins
pubmed
31040184
uniprot
proteins
pubmed
31040185
uniprot
proteins
pubmed
7529123
uniprot
proteins
pubmed
8648694
uniprot
proteins
sequence_length
551
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:31040184, ECO:0000269|PubMed:31040185}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 241..265; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins