Eps15
entrez
13858
canonical
uniprot
P42567
canonical
ensembl
ENSMUSG00000028552
resolver
ensp
ENSMUSP00000030281
resolver
ensp
ENSMUSP00000099790
resolver
ensp
ENSMUSP00000135270
resolver
ensp
ENSMUSP00000238525
resolver
ensp
ENSMUSP00000238526
resolver
ensp
ENSMUSP00000238537
resolver
enst
ENSMUST00000030281
resolver
enst
ENSMUST00000175776
resolver
genesymbol
Eps15
resolver
uniprot
A0A0R4J0A0
resolver
uniprot
H3BK65
resolver
uniprot
Q80ZL3
resolver
uniprot
Q8C431
resolver
uniprot_entry
A0A0R4J0A0_MOUSE
resolver
uniprot_entry
EPS15_MOUSE
resolver
uniprot_entry
H3BK65_MOUSE
resolver
uniprot_entry
Q80ZL3_MOUSE
resolver
uniprot_sec
Q8C431
resolver
amino_acid_sequence
MAAAAQLSLTQLSSGNPVYEKYYRQVEAGNTGRVLALDAAAFLKKSGLPDLILGKIWDLADTDGKGVLSKQEFFVALRLVACAQNGLEVSLSSLSLAVPPPRFHDSSSPLLTSGPSVAELPWAVKSEDKAKYDAIFDSLSPVDGFLSGDKVKPVLLNSKLPVEILGRVWELSDIDHDGKLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGYVSGLEVRETFLKTGLPSALLAHIWSLCDTKGCGKLSKDQFALAFHLINQKLIKGIDPPHSLTPEMIPPSDRSSLQKNITGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTVKQRTSEVQDLQDEVQRESINLQKLQAQKQQVQELLGELDEQKAQLEEQLQEVRKKCAEEAQLISSLKAEITSQESQISSYEEELLKAREELSRLQQETAQLEESVESGKAQLEPLQQHLQESQQEISSMQMRLEMKDLETDNNQSNWSSSPQSVLVNGATDYCSLSTSSSETANFNEHAEGQNNLESEPTHQESSVRSSPEIAPSDVTDESEAVTVAGNEKVTPRFDDDKHSKEEDPFNVESSSLTDAVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFKQTSTDPFTTSSTDPFSASSNSSNTSVETWKHNDPFAPGGTVVAAASDSATDPFASVFGNESFGDGFADFSTLSKVNNEDAFNPTISSSTSSVTIAKPMLEETASKSEDVPPALPPKVGTPTRPCPPPPGKRPINKLDSSDPLKLNDPFQPFPGNDSPKEKDPDMFCDPFTSSTTTNKEADPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA
uniprot
proteins
function
FUNCTION: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
uniprot
proteins
mass_dalton
98471
uniprot
proteins
mutagenesis
MUTAGEN 850; /note="Y->F: Inefficient EGFR internalization."; /evidence="ECO:0000269|PubMed:10953014"; MUTAGEN 863; /note="E->A: Loss of interaction with UBQLN1; when associated with A-864 and A-865."; /evidence="ECO:0000269|PubMed:16159959"; MUTAGEN 864; /note="S->A: Loss of interaction with UBQLN1; when associated with A-863 and A-865."; /evidence="ECO:0000269|PubMed:16159959"; MUTAGEN 865; /note="E->A: Loss of interaction with UBQLN1; when associated with A-863 and A-864."; /evidence="ECO:0000269|PubMed:16159959"; MUTAGEN 883; /note="L->A: Loss of ubiquitination and interaction with UBQLN1; when associated with A-885."; /evidence="ECO:0000269|PubMed:16159959"; MUTAGEN 885; /note="L->A: Loss of ubiquitination and interaction with UBQLN1; when associated with A-883."; /evidence="ECO:0000269|PubMed:16159959
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylation on Tyr-850 is involved in the internalization of EGFR. Not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis. {ECO:0000250, ECO:0000269|PubMed:10953014}.; PTM: Ubiquitinated. {ECO:0000269|PubMed:16159959}.
uniprot
proteins
pubmed
10393179
uniprot
proteins
pubmed
10471276
uniprot
proteins
pubmed
10953014
uniprot
proteins
pubmed
12057195
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16159959
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17626015
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20448150
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21762413
uniprot
proteins
pubmed
22648170
uniprot
proteins
pubmed
7689153
uniprot
proteins
sequence_length
897
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes. {ECO:0000250|UniProtKB:P42566}.; SUBCELLULAR LOCATION: [Isoform 2]: Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with HGS on bilayered clathrin coats on endosomes. {ECO:0000250}.
uniprot
proteins