Micu2
entrez
68514
canonical
uniprot
Q8CD10
canonical
ensembl
ENSMUSG00000021973
resolver
ensp
ENSMUSP00000022543
resolver
ensp
ENSMUSP00000305275
resolver
ensp
ENSMUSP00000305278
resolver
enst
ENSMUST00000022543
resolver
genesymbol
Micu2
resolver
genesymbol_syn
Efha1
resolver
uniprot
Q3TJU4
resolver
uniprot
Q8K0K2
resolver
uniprot
Q9CUR8
resolver
uniprot_entry
MICU2_MOUSE
resolver
uniprot_sec
Q3TJU4
resolver
uniprot_sec
Q8K0K2
resolver
uniprot_sec
Q9CUR8
resolver
amino_acid_sequence
MAAAAGRSAWLAAWGGRLRRGLAAGRRAVPTRGPLAAAVAGVALAGAGAAWHHGRVKAAAREGSRTVSAQKNYLGPIEKLSLRKQRFMQFSSLEHDGEYYMTPRDFLFSVMFEQVERKTLVKKLAKKDIEDVLSGIQTARCGSTFFRDLGDKGVISYTEYLFLLTILTKPHSGFHVAFKMLDVDGNEMIERKEFVKLQKIISKQDGFKTVKTNETEYQDPTVKEPGVNTTLQVRFFGKRGEKKLHYKEFRRFMENLQTEVQEMEFLQFSKGLNFMRKEDFAEWLLFFTNTENKDIYWRNVREKLSVGESISLDEFKSFCHFTTHLEDFAIAMQMFSLAHRPVRLAEFKRAVKVATGQELSDNLLDTVFKIFDLDGDECLSHGEFLGVLKNRMHRGLWVSQQQSVQEYWKCVKKESIKGVKEAWRQQAGKGPF
uniprot
proteins
function
FUNCTION: Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains (PubMed:23409044, PubMed:24560927). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium (PubMed:24560927). At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake (By similarity). At higher calcium levels, calcium-binding to MICU1 and MICU2 induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU2 heterodimer away from the pore, allowing calcium permeation through the MCU channel (By similarity). {ECO:0000250|UniProtKB:Q8IYU8, ECO:0000269|PubMed:23409044, ECO:0000269|PubMed:24560927}.
uniprot
proteins
mass_dalton
49476
uniprot
proteins
mutagenesis
MUTAGEN 372; /note="D->A: Strong reduction of mitochondrial Ca(2+) peaks."; /evidence="ECO:0000269|PubMed:24560927"; MUTAGEN 410; /note="C->A: Abolishes interaction with MICU2."; /evidence="ECO:0000269|PubMed:24560927
uniprot
proteins
protein_family
MICU1 family
uniprot
proteins
protein_family
MICU2 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23409044
uniprot
proteins
pubmed
24560927
uniprot
proteins
pubmed
29073106
uniprot
proteins
pubmed
30755530
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000269|PubMed:23409044}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8IYU8}. Note=Recruited to the mitochondrial inner membrane via its association with the uniplex complex. {ECO:0000250|UniProtKB:Q8IYU8}.
uniprot
proteins