Irf6
entrez
54139
canonical
uniprot
P97431
canonical
ensembl
ENSMUSG00000026638
resolver
ensp
ENSMUSP00000075839
resolver
ensp
ENSMUSP00000254515
resolver
enst
ENSMUST00000076521
resolver
genesymbol
Irf6
resolver
uniprot
Q91VD0
resolver
uniprot_entry
IRF6_MOUSE
resolver
uniprot_sec
Q91VD0
resolver
amino_acid_sequence
MALHPRRVRLKPWLVAQVDSGLYPGLIWLHRDSKRFQIPWKHATRHSPQQEEENTIFKAWAVETGKYQEGVDDPDPAKWKAQLRCALNKSREFNLMYDGTKEVPMNPVKIYQVCDIPQTQGSVINPGSTGSAPWDEKDNDVDEDEEEDELEQSQHHVPIQDTFPFLNINGSPMAPASVGNCSVGNCSPESVWPKTEPLEMEVPQAPIQPFYSSPELWISSLPMTDLDIKFQYRGKEYGQTMTVSNPQGCRLFYGDLGPMPDQEELFGPVSLEQVKFPGPEHITNEKQKLFTSKLLDVMDRGLILEVSGHAIYAIRLCQCKVYWSGPCAPSLAAPNLIERQKKVKLFCLETFLSELIAHQKGQIEKQPPFEIYLCFGEEWPDGKPLERKLILVQVIPVVARMIYEMFSGDFTRSFDSGSVRLQISTPDIKDNIVAQLKQLYRILQTQESWQPMQPAPSMQLPQALPAQ
uniprot
proteins
function
FUNCTION: Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. {ECO:0000269|PubMed:17041603, ECO:0000269|PubMed:18212048, ECO:0000269|PubMed:19036739, ECO:0000269|PubMed:21574244}.
uniprot
proteins
mass_dalton
53111
uniprot
proteins
mutagenesis
MUTAGEN 84; /note="R->C: Mice show an atypical limb development, are covered by an abnormal smooth skin and die shortly after birth. The esophageal lumen is obliterated by adhesion of the stratified, squamous epithelium lining this structure. The hindlimbs, tail and body are fused together by a thickened epidermis. Epidermis is hyperproliferative but does not undergo a normal differentiation program."; /evidence="ECO:0000269|PubMed:17041603
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation. {ECO:0000250}.
uniprot
proteins
protein_family
IRF family
uniprot
proteins
pubmed
12219090
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17041603
uniprot
proteins
pubmed
18212048
uniprot
proteins
pubmed
19036739
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21574244
uniprot
proteins
sequence_length
467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:19036739}. Note=Translocates to nucleus in response to an activating signal. {ECO:0000305}.
uniprot
proteins