Pycr3
entrez
300035
canonical
uniprot
Q5PQJ6
canonical
genesymbol
Pycr3
resolver
genesymbol_syn
Pycrl
resolver
uniprot_entry
P5CR3_RAT
resolver
amino_acid_sequence
MADEMSEPRRVGFVGAGRMAEAIAQGLIRAGKVEAKQVLASAPTDKNLCHFRALGCQTTHSNHEVLQNCPLVIFATKPQVLPAVLAEVAPVVTTEHIIVSVAAGISLSSMEELLPPKTRVLRVSPNLPCVVQEGAMVMTRGHHAGNEDAKLLQNLLEACGQCIEVPESYVDIHTGLSGSGVAFVCTFSEALAEGAIKMGMPSDLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHGLHALEQGGFRAAAMSAVEAATCRAKELSKK
uniprot
proteins
ec_number
1.5.1.2
uniprot
proteins
function
FUNCTION: Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate (P5C) to L-proline using NAD(P)H. Proline is synthesized from either glutamate or ornithine; both are converted to P5C, and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCR3 is exclusively linked to the biosynthesis of proline from ornithine. {ECO:0000250|UniProtKB:Q53H96}.
uniprot
proteins
mass_dalton
28878
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. {ECO:0000250|UniProtKB:Q53H96}.
uniprot
proteins
protein_family
Pyrroline-5-carboxylate reductase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q53H96}.
uniprot
proteins