Lax1
entrez
240754
canonical
uniprot
Q8BHB3
canonical
ensembl
ENSMUSG00000051998
resolver
ensp
ENSMUSP00000131126
resolver
ensp
ENSMUSP00000307042
resolver
enst
ENSMUST00000169295
resolver
genesymbol
Lax1
resolver
genesymbol_syn
Lax
resolver
uniprot
Q8BS18
resolver
uniprot
Q8CGV1
resolver
uniprot_entry
LAX1_MOUSE
resolver
uniprot_sec
Q8BS18
resolver
uniprot_sec
Q8CGV1
resolver
amino_acid_sequence
MYSTPAPPEVTRRNSEPSTRQGTLGSLQGEKGQIIFPGFVVLLTIILVIIAACILWSWKKQKKRPVPYFQVAPSLTLPPPRHRAKNIYDFLPRQQTELGRHQLSGFSTESLLSRASDSPEPEAPQANGSLQMHRVSVHTVEYSVNIYDNGTVPQMCRHLASSTHHVCVRTSRSNPSISSKESNDYVNIPTVEDTCETLTRIESTPENHLGLPSALRLEFAEGGHAGCGNATDHDGFWAPGPKCSDSLSDGDDLSQTSNDYVNMTGLDLENIQENRPRGAFQCCRDYENVPWVDTNESQLPTLEEVASSTVDHREPVWRTLSSVYHMAFQPSAQSEDSAMVHREEQSSEDSSDYETVLVAELEGRDWKQGPGTQHPSDEGTPGDLAGKLCEVVYPAGSLATETSDEDA
uniprot
proteins
function
FUNCTION: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. {ECO:0000269|PubMed:15843560}.
uniprot
proteins
mass_dalton
44838
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines upon TCR or BCR activation; which leads to the recruitment of GRB2, PIK3R1 and GRAP2. {ECO:0000250}.
uniprot
proteins
pubmed
12359715
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15843560
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins