EDEM1
entrez
9695
canonical
uniprot
Q92611
canonical
ensembl
ENSG00000134109
resolver
ensp
ENSP00000256497
resolver
ensp
ENSP00000668011
resolver
ensp
ENSP00000668012
resolver
genesymbol
EDEM1
resolver
genesymbol_syn
EDEM
resolver
genesymbol_syn
KIAA0212
resolver
hgnc
HGNC:18967
resolver
uniprot
A8K9C8
resolver
uniprot
B4DXP3
resolver
uniprot_entry
EDEM1_HUMAN
resolver
uniprot_sec
A8K9C8
resolver
uniprot_sec
B4DXP3
resolver
amino_acid_sequence
MQWRALVLGLVLLRLGLHGVLWLVFGLGPSMGFYQRFPLSFGFQRLRSPDGPASPTSGPVGRPGGVSGPSWLQPPGTGAAQSPRKAPRRPGPGMCGPANWGYVLGGRGRGPDEYEKRYSGAFPPQLRAQMRDLARGMFVFGYDNYMAHAFPQDELNPIHCRGRGPDRGDPSNLNINDVLGNYSLTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDKDSTVQVFEATIRVLGSLLSAHRIITDSKQPFGDMTIKDYDNELLYMAHDLAVRLLPAFENTKTGIPYPRVNLKTGVPPDTNNETCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWNLRSNDTGLLGNVVNIQTGHWVGKQSGLGAGLDSFYEYLLKSYILFGEKEDLEMFNAAYQSIQNYLRRGREACNEGEGDPPLYVNVNMFSGQLMNTWIDSLQAFFPGLQVLIGDVEDAICLHAFYYAIWKRYGALPERYNWQLQAPDVLFYPLRPELVESTYLLYQATKNPFYLHVGMDILQSLEKYTKVKCGYATLHHVIDKSTEDRMESFFLSETCKYLYLLFDEDNPVHKSGTRYMFTTEGHIVSVDEHLRELPWKEFFSEEGGQDQGGKSVHRPKPHELKVINSSSNCNRVPDERRYSLPLKSIYMRQIDQMVGLI
uniprot
proteins
function
FUNCTION: Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2. {ECO:0000269|PubMed:12610306, ECO:0000269|PubMed:19524542, ECO:0000269|PubMed:19934218, ECO:0000269|PubMed:25092655}.
uniprot
proteins
mass_dalton
73768
uniprot
proteins
mutagenesis
MUTAGEN 225; /note="E->Q: Normal affinity for misfolded glycoproteins, but impaired SEL1L binding."; /evidence="ECO:0000269|PubMed:19524542"; MUTAGEN 370; /note="D->N: Normal affinity for misfolded glycoproteins, but impaired SEL1L binding."; /evidence="ECO:0000269|PubMed:19524542"; MUTAGEN 493; /note="E->Q: Normal affinity for misfolded glycoproteins, but impaired SEL1L binding."; /evidence="ECO:0000269|PubMed:19524542
uniprot
proteins
protein_family
Glycosyl hydrolase 47 family
uniprot
proteins
pubmed
12610306
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16449189
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
19524542
uniprot
proteins
pubmed
19934218
uniprot
proteins
pubmed
25092655
uniprot
proteins
pubmed
9039502
uniprot
proteins
sequence_length
657
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19934218}; Single-pass type II membrane protein {ECO:0000269|PubMed:19934218}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins