Dtnb
entrez
362715
canonical
uniprot
P84060
canonical
ensembl
ENSRNOG00000011914
resolver
ensp
ENSRNOP00000057536
resolver
ensp
ENSRNOP00000092832
resolver
genesymbol
Dtnb
resolver
uniprot
Q66HF4
resolver
uniprot_entry
DTNB_RAT
resolver
uniprot_sec
Q66HF4
resolver
amino_acid_sequence
MIEEGGNKRKTMAEKRQLFIEMRAQNFDVIRLSTYRTACKLRFVQKRCNLHLVDIWNMIEAFRDNGLNTLDHATEISVSRLETVISSIYYQLNKRLPSTHQINVEQSISLLLNFMIAAYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRYIFSQMSDSNGLMMFGKLDQFLKEALKLPTAVFEGPSFGYTEHAVRTCFPQQKKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVFHPVECSYCHCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKELSSWKSPAKKLSHAISKSLGCVPSREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYGQDMPNLLADEHALIASYVARLQHCTRVLDSPSRLDEEHRLIARYAARLAAEAGNMTRPPTDASFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEGLMKLLKAQATGSPHTSPTHGGGRSMPMPVRSTSAGSTPTHGPQDSLSGVGGDVQEAFAQGTRRNLRNDLLVAADSITNTMSSLVKELHSGETQRFPLVSSSPSCPLPCPTIPTHSPSFHATFPSRNTRDLHPVPPSHMVSLY
uniprot
proteins
function
FUNCTION: Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids. May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation. May be required for proper maturation and function of a subset of inhibitory synapses. {ECO:0000250|UniProtKB:O70585}.
uniprot
proteins
mass_dalton
73878
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA. Phosphorylation at Thr-11 alters the interaction with KIF5A. {ECO:0000250|UniProtKB:O70585}.
uniprot
proteins
protein_family
Dystrobrevin subfamily
uniprot
proteins
protein_family
Dystrophin family
uniprot
proteins
pubmed
10545507
uniprot
proteins
pubmed
14600269
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17265465
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8889548
uniprot
proteins
sequence_length
654
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O70585}. Postsynaptic density {ECO:0000269|PubMed:10545507}. Cell projection, dendrite {ECO:0000250|UniProtKB:O70585}. Basal cell membrane {ECO:0000250|UniProtKB:O70585}. Postsynapse {ECO:0000250|UniProtKB:O70585}. Nucleus {ECO:0000250|UniProtKB:O70585}. Note=Localized at inhibitory synapses on the dendrites of cerebellar Purkinje cells. {ECO:0000250|UniProtKB:O70585}.
uniprot
proteins