Pym1
entrez
78428
canonical
uniprot
Q8CHP5
canonical
ensembl
ENSMUSG00000064030
resolver
ensp
ENSMUSP00000067623
resolver
ensp
ENSMUSP00000129789
resolver
ensp
ENSMUSP00000151691
resolver
ensp
ENSMUSP00000280157
resolver
ensp
ENSMUSP00000280159
resolver
enst
ENSMUST00000218218
resolver
genesymbol
Pym1
resolver
genesymbol_syn
Pym
resolver
genesymbol_syn
Wibg
resolver
uniprot
A0A1W2P7L0
resolver
uniprot
Q80YD2
resolver
uniprot_entry
A0A1W2P7L0_MOUSE
resolver
uniprot_entry
PYM1_MOUSE
resolver
uniprot_sec
Q80YD2
resolver
amino_acid_sequence
METASTPEATGTGKYIASTQRPDGTWRKQRRVKEGYVPQEEVPVYENKYVKFFKSKPELPPGLSPEATTPVTPSRPEGGETGLSKTAKRNLKRKEKRRQQQEKEAEALSRTLDKVSLGDTAQIPSALQGPQATPLAASDPSDSAATTEKAKKIKNLRKKLRQVEELQQRIQAGEVSQPSREQLEKLARRRVLEEELEDLELGL
uniprot
proteins
function
FUNCTION: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
22690
uniprot
proteins
protein_family
Pym family
uniprot
proteins
pubmed
12438415
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BRP8}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9BRP8}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9BRP8}. Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by XPO1/CRM1. {ECO:0000250|UniProtKB:Q9BRP8}.
uniprot
proteins