Prim2
entrez
301323
canonical
uniprot
O89044
canonical
ensembl
ENSRNOG00000012486
resolver
ensembl
ENSRNOG00055001642
resolver
ensembl
ENSRNOG00060026674
resolver
ensembl
ENSRNOG00065011419
resolver
ensp
ENSRNOP00000016828
resolver
ensp
ENSRNOP00000057197
resolver
ensp
ENSRNOP00000104632
resolver
ensp
ENSRNOP00055001955
resolver
ensp
ENSRNOP00060038389
resolver
ensp
ENSRNOP00065014190
resolver
enst
ENSRNOT00000016828
resolver
enst
ENSRNOT00000060452
resolver
enst
ENSRNOT00055002627
resolver
enst
ENSRNOT00060046212
resolver
enst
ENSRNOT00065018557
resolver
genesymbol
Prim2
resolver
uniprot
F7FBI3
resolver
uniprot
Q4V8C0
resolver
uniprot_entry
F7FBI3_RAT
resolver
uniprot_entry
PRI2_RAT
resolver
uniprot_entry
Q4V8C0_RAT
resolver
amino_acid_sequence
MQFSGRTRKKLRLAGDQRNACYPHSLQFYLQPPTENISLTEFESLAFDRVKLLKAIENLGVSYVKGTEQYQSKLEAEIRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEDLRRWFIQQEMDLLRFRFSILPKDKVQSFLKDTHLHFEAISDEEKTLREQDIMASSPSLSGVRWESESVYKVPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRATLSKALALTARSLPAVQSDERLQPLLSHLSHSYTGQDYSTQKSTGKISLDQIDSLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLTLEQALQFWKQEFIKGKMDPDKFDKGYSYNIRHSFGKEGKRTDYTPFSCMKIILTNPPSQGDFHGCPFRHSDAELLKQKMQTYKIPASGISQILDLVKGNHYQVACQKYFEMTHNVDDCGFSLNHPNQFFFESQRILTGGKDIKKEASHPETPQHKPSTQKTKDATSALASLDSSLEMDLEGLEDYFSK
uniprot
proteins
function
FUNCTION: Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (By similarity). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerizing short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (By similarity). Binds RNA:DNA duplex and coordinates the catalytic activities of PRIM1 and POLA2 during primase-to-polymerase switch. {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P33610, ECO:0000250|UniProtKB:P49643}.
uniprot
proteins
mass_dalton
58603
uniprot
proteins
protein_family
Eukaryotic-type primase large subunit family
uniprot
proteins
sequence_length
507
uniprot
proteins