NANOS3
entrez
342977
canonical
uniprot
P60323
canonical
ensembl
ENSG00000187556
resolver
ensembl
ENSG00000288505
resolver
ensp
ENSP00000341992
resolver
genesymbol
NANOS3
resolver
genesymbol_syn
NOS3
resolver
hgnc
HGNC:22048
resolver
uniprot
Q495E5
resolver
uniprot_entry
NANO3_HUMAN
resolver
uniprot_sec
Q495E5
resolver
amino_acid_sequence
MGTFDLWTDYLGLAHLVRALSGKEGPETRLSPQPEPEPMLEPDQKRSLESSPAPERLCSFCKHNGESRAIYQSHVLKDEAGRVLCPILRDYVCPQCGATRERAHTRRFCPLTGQGYTSVYSHTTRNSAGKKLVRPDKAKTQDTGHRRGGGGGAGFRGAGKSEPSPSCSPSMST
uniprot
proteins
function
FUNCTION: Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. {ECO:0000269|PubMed:21421998}.
uniprot
proteins
mass_dalton
18844
uniprot
proteins
protein_family
Nanos family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21421998
uniprot
proteins
pubmed
8889548
uniprot
proteins
sequence_length
173
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21421998}. Cytoplasm {ECO:0000269|PubMed:21421998}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P60324}. Cytoplasm, P-body {ECO:0000250|UniProtKB:P60324}. Note=Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body. {ECO:0000250|UniProtKB:P60324}.
uniprot
proteins