DKKL1
entrez
27120
canonical
uniprot
Q9UK85
canonical
ensembl
ENSG00000104901
resolver
ensp
ENSP00000221498
resolver
ensp
ENSP00000472056
resolver
ensp
ENSP00000472866
resolver
enst
ENST00000221498
resolver
genesymbol
DKKL1
resolver
genesymbol_syn
SGY1
resolver
hgnc
HGNC:16528
resolver
uniprot
A0A140VK15
resolver
uniprot_entry
A0A140VK15_HUMAN
resolver
uniprot_entry
DKKL1_HUMAN
resolver
amino_acid_sequence
MGEASPPAPARRHLLVLLLLLSTLVIPSAAAPIHDADAQESSLGLTGLQSLLQGFSRLFLKGNLLRGIDSLFSAPMDFRGLPGNYHKEENQEHQLGNNTLSSHLQIDKMTDNKTGEVLISENVVASIQPAEGSFEGDLKVPRMEEKEALVPIQKATDSFHTELHPRVAFWIIKLPRRRSHQDALEGGHWLSEKRHRLQAIRDGLRKGTHKDVLEEGTESSSHSRLSPRKTHLLYILRPSRQL
uniprot
proteins
function
FUNCTION: Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility. {ECO:0000250|UniProtKB:Q9QZL9}.
uniprot
proteins
mass_dalton
27007
uniprot
proteins
post_translational_modification
PTM: N-glycosylated during spermatogenesis. Not N-glycosylated in mature sperm. {ECO:0000250|UniProtKB:Q9QZL9}.
uniprot
proteins
pubmed
10570958
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22817830
uniprot
proteins
sequence_length
242
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9QZL9}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9QZL9}. Note=Localized specifically to the crescent shaped acrosome at the apex of the sperm head. {ECO:0000250|UniProtKB:Q9QZL9}.
uniprot
proteins