RPRD1A
entrez
55197
canonical
uniprot
Q96P16
canonical
ensembl
ENSG00000141425
resolver
ensp
ENSP00000381984
resolver
ensp
ENSP00000465444
resolver
ensp
ENSP00000467991
resolver
ensp
ENSP00000468209
resolver
enst
ENST00000589050
resolver
genesymbol
RPRD1A
resolver
genesymbol_syn
P15RS
resolver
hgnc
HGNC:25560
resolver
uniprot
A0A0C4DGQ6
resolver
uniprot
A8KA42
resolver
uniprot
B2RBA3
resolver
uniprot
Q7Z5G8
resolver
uniprot
Q96FY9
resolver
uniprot
Q9NVL4
resolver
uniprot_entry
A0A0C4DGQ6_HUMAN
resolver
uniprot_entry
RPR1A_HUMAN
resolver
uniprot_sec
A8KA42
resolver
uniprot_sec
B2RBA3
resolver
uniprot_sec
Q7Z5G8
resolver
uniprot_sec
Q96FY9
resolver
uniprot_sec
Q9NVL4
resolver
amino_acid_sequence
MSAFSEAALEKKLSELSNSQQSVQTLSLWLIHHRKHSRPIVTVWERELRKAKPNRKLTFLYLANDVIQNSKRKGPEFTKDFAPVIVEAFKHVSSETDESCKKHLGRVLSIWEERSVYENDVLEQLKQALYGDKKPRKRTYEQIKVDENENCSSLGSPSEPPQTLDLVRALQDLENAASGDAAVHQRIASLPVEVQEVSLLDKITDKESGERLSKMVEDACMLLADYNGRLAAEIDDRKQLTRMLADFLRCQKEALAEKEHKLEEYKRKLARVSLVRKELRSRIQSLPDLSRLPNVTGSHMHLPFAGDIYSED
uniprot
proteins
function
FUNCTION: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}.
uniprot
proteins
mass_dalton
35720
uniprot
proteins
mutagenesis
MUTAGEN 65; /note="D->A: Partial loss of binding to POLR2ACTD in vitro."; /evidence="ECO:0000269|PubMed:24997600"; MUTAGEN 106; /note="R->A: Partial loss of binding to POLR2ACTD phosphorylated at 'Ser-2' in the heptad repeats in vitro."; /evidence="ECO:0000269|PubMed:24997600"; MUTAGEN 114; /note="R->A: Partial loss of binding to POLR2ACTD in vitro."; /evidence="ECO:0000269|PubMed:24997600
uniprot
proteins
protein_family
UPF0400 (RTT103) family
uniprot
proteins
pubmed
12470661
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22231121
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24399136
uniprot
proteins
pubmed
24997600
uniprot
proteins
sequence_length
312
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22231121}.
uniprot
proteins