Abca8b
entrez
27404
canonical
uniprot
Q8K440
canonical
ensembl
ENSMUSG00000020620
resolver
ensp
ENSMUSP00000020948
resolver
ensp
ENSMUSP00000102280
resolver
ensp
ENSMUSP00000192460
resolver
ensp
ENSMUSP00000192461
resolver
ensp
ENSMUSP00000192462
resolver
genesymbol
Abca8b
resolver
genesymbol_syn
Abca8
resolver
genesymbol_syn
Kiaa0822
resolver
uniprot
A2AM55
resolver
uniprot
A2AM56
resolver
uniprot
Q69ZY4
resolver
uniprot
Q8BRQ1
resolver
uniprot
Q9JL38
resolver
uniprot_entry
A2AM56_MOUSE
resolver
uniprot_entry
ABC8B_MOUSE
resolver
uniprot_sec
A2AM55
resolver
uniprot_sec
Q69ZY4
resolver
uniprot_sec
Q8BRQ1
resolver
uniprot_sec
Q9JL38
resolver
activity_regulation
ACTIVITY REGULATION: Cholesterol efflux is increased by extracellularly applied taurocholate. {ECO:0000250|UniProtKB:O94911}.
uniprot
proteins
amino_acid_sequence
MIKREISVRQQTCALLQKNLLKKWRLKRESLMEWVSSLLLLLFLYWYPHGHGATDLSSVPTKDLGRVDSFRQSGFMIGYTPVTSMTQQIMEKVAATPFMADKKVLGLLDEENIKELTESHAEIIRVIFSDTFSYHLKFQFDQRIPTSRELRDHNAHCDGLYEDVNCLIAIFWKEGFVALQAAINAAIIETTTNHSVMEELLSVSGKFMKIHPFVRQEGILTDFFIFTCIISFSPITYYVSINVARERKRMKGLMMMMGLRDPAFWLSWGLLYAGFVFIMALSLALVIKSVQFFILTSFMVVFSLFLLYGLSMITLAFLMSALVRKSVLTGLSVFLLTIFWGSLGFTSLYRYLPAPVEWTLSLFSPFAFTLGMAQLLRVDYDLNSNAPPDPASGSNLIIATNFMLVFDAFLYLALMMYFEKVLPNEYGHQHSPLFFLKSSFWLQTRKPAHVILEDGIDPVPSSGDSFEPVSPEFHGKESIRIRNISKEYKGKPNKIEALKDLTLDIYEGQITAVLGHSGAGKSTLLNILSGLSVPTKGSVTIYNNNLSEMADLENILRIAGVCPQANVQFDFLTVRENLRLFAKIRGIPPQDVEKEVQRVLLELEMKNIQNILAQNLSGGQKRKLTFGIAILGDSQIFLLDEPTAGLDPFSRHRVWNLLKERRADRVVLFSTQFMDEADILADRKVFISNGRLKCAGSSLFLKKKWGVGYHLSLQLKEVCVPENITSLVKQHIPAAKLSAEGEGKLLYTLPLETTYRFPELCQSLDSCPGLGIENYGVSMTTLNEVFLKLEGKASIDEPEVDIVGEGQTERSGDTERLMEMEQTLSSLRETEKTDGMALWRQQTCAIAKVRLLKLKHERKTLLSVLLILVVGICPFLFENISTKIRQSSYTWELSPHDYFLAPGQQPQGMLTQLLIINKTEASIDDFIHSVERQNIALEVDASGTRDGTDDPSYNGALIVSGNEKNHSFSFACNTKRLNCFPVLMDILSNGLLGMVKPSARIQTDRSTYLMDETIHPLEDLWKTAFWLILTSACPPYIAMSSVTDYKNRAWFQLRVSGLFPSAYWVGQAMVDIPLYCFVFLFMSLMDYLFRFPDTMFSIISHVIQIPCSVGYAISLIFLTYVISFISRKGKKNSGIWSLSFYIITVFSVAVILLAFDVDGTQYYIIFLIPPSTLVGCLILSLHLFIGQIFEEGQVIEPFLVFLIPFLHVFIFIFTLRCLEWKFGKKTMRKDPIFRISPRNNDVYQNPEEPEDEDEDVQMERMRTANALVSTSFDEKPVIIASCLRKEYAGKQKHCLSKKKAKIATRNVSFCVRKGEILGLLGHNGAGKSTSLKMISGDTKVTAGQVLLKGSREGDTPGFLGYCPQENALWPNLTVKEHLEIFAAVRGLRKSHAAVAITRLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSILLLDEPSTGLDPEGQQQIWQAIRAIIKNTDRGALLTTHYMAEAEALCDRVAILVSGRLRCIGSIQHLKSKFGKDYLLEMKVKTLEQVEPLNTEILRLFPQASRQERYSSLMAYKLPVEAVQPLSQAFFKLEKVKQTFDLEEYSLSQSTLEQVFLELSKEQELDGLELEELDSSIKWKLLPQEEA
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
function
FUNCTION: Mediates cholesterol and taurocholate efflux (PubMed:28882873). Through the interaction with ABCA1 potentiates the cholesterol efflux to lipid-free APOA1, in turn regulates high-density lipoprotein cholesterol levels (By similarity). {ECO:0000250|UniProtKB:O94911, ECO:0000269|PubMed:28882873}.
uniprot
proteins
mass_dalton
183039
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCA family
uniprot
proteins
pubmed
10708515
uniprot
proteins
pubmed
12532264
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16445568
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28882873
uniprot
proteins
pubmed
29300488
uniprot
proteins
sequence_length
1620
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O94911}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O94911}. Basolateral cell membrane {ECO:0000269|PubMed:29300488}. Note=Predominantly expressed on the sinusoidal plasma membrane in hepatocytes. {ECO:0000269|PubMed:29300488}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 223..243; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 267..287; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 298..318; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 326..346; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 352..372; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 396..416; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 860..880; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 979..999; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1023..1043; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1069..1089; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1105..1125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1135..1155; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1164..1184; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1194..1214; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins