Atp6ap1
entrez
54411
canonical
uniprot
Q9R1Q9
canonical
ensembl
ENSMUSG00000019087
resolver
ensp
ENSMUSP00000019231
resolver
ensp
ENSMUSP00000109808
resolver
ensp
ENSMUSP00000295357
resolver
ensp
ENSMUSP00000295368
resolver
enst
ENSMUST00000019231
resolver
enst
ENSMUST00000114171
resolver
genesymbol
Atp6ap1
resolver
genesymbol_syn
Atp6ip1
resolver
genesymbol_syn
Atp6s1
resolver
uniprot
F6WU95
resolver
uniprot
Q3TKX1
resolver
uniprot
Q3TWN7
resolver
uniprot
Q3UWN7
resolver
uniprot_entry
F6WU95_MOUSE
resolver
uniprot_entry
Q3TKX1_MOUSE
resolver
uniprot_entry
Q3TWN7_MOUSE
resolver
uniprot_entry
Q3UWN7_MOUSE
resolver
uniprot_entry
VAS1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: In response to calorie restriction, associates with metformin-bound PSENEN, leading to the inactivation of the V-ATPase complex and activation of AMPK via the AXIN1-STK11/LKB1 axis. {ECO:0000269|PubMed:35197629}.
uniprot
proteins
amino_acid_sequence
MMAATVVSRIRTGTGRAPVMWLSLSLVAVAAAVATEQQVPLVLWSSDRNLWAPVADTHEGHITSDMQLSTYLDPALELGPRNVLLFLQDKLSIEDFTAYGGVFGNKQDSAFSNLENALDLAPSSLVLPAVDWYAISTLTTYLQEKLGASPLHVDLATLKELKLNASLPALLLIRLPYTASSGLMAPREVLTGNDEVIGQVLSTLKSEDVPYTAALTAVRPSRVARDITMVAGGLGRQLLQTQVASPAIHPPVSYNDTAPRILFWAQNFSVAYKDEWKDLTSLTFGVENLNLTGSFWNDSFAMLSLTYEPLFGATVTFKFILASRFYPVSARYWFAMERLEIHSNGSVAHFNVSQVTGPSIYSFHCEYVSSVSKKGNLLVTNVPSVWQMTLHNFQIQAFNVTGEQFSYASDCAGFFSPGIWMGLLTTLFMLFIFTYGLHMILSLKTMDRFDDHKGPTITLTQIV
uniprot
proteins
function
FUNCTION: Accessory subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:18713856). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (PubMed:35197629). Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity (By similarity). Involved in membrane trafficking and Ca(2+)-dependent membrane fusion (By similarity). May play a role in the assembly of the V-type ATPase complex (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). In islets of Langerhans cells, may regulate the acidification of dense-core secretory granules (PubMed:18713856). {ECO:0000250|UniProtKB:Q15904, ECO:0000269|PubMed:18713856, ECO:0000269|PubMed:35197629}.
uniprot
proteins
mass_dalton
51008
uniprot
proteins
mutagenesis
MUTAGEN 222..225; /note="RVAR->AVAA: Impairs propeptide cleavage."; /evidence="ECO:0000269|PubMed:18713856
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:18713856}.
uniprot
proteins
protein_family
Vacuolar ATPase subunit S1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18713856
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27231034
uniprot
proteins
pubmed
35197629
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15904}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q15904}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q15904}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O54715}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:O54715}; Single-pass type I membrane protein {ECO:0000305}. Note=Not detected in trans-Golgi network. {ECO:0000250|UniProtKB:Q15904}.
uniprot
proteins
transmembrane_region
TRANSMEM 413..433; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins