DNASE1
entrez
1773
canonical
uniprot
P24855
canonical
ensembl
ENSG00000213918
resolver
ensp
ENSP00000246949
resolver
ensp
ENSP00000795420
resolver
genesymbol
DNASE1
resolver
genesymbol_syn
DNL1
resolver
genesymbol_syn
DRNI
resolver
hgnc
HGNC:2956
resolver
uniprot
B4DV35
resolver
uniprot
Q14UU9
resolver
uniprot
Q14UV0
resolver
uniprot_entry
DNAS1_HUMAN
resolver
uniprot_sec
B4DV35
resolver
uniprot_sec
Q14UU9
resolver
uniprot_sec
Q14UV0
resolver
amino_acid_sequence
MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
uniprot
proteins
disease_involvement
DISEASE: Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269|PubMed:11479590, ECO:0000269|PubMed:20439745}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. Neutrophil extracellular traps (NETs) are impaired in patients suffering from SLE (PubMed:20439745). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:20439745). {ECO:0000269|PubMed:20439745}.
uniprot
proteins
ec_number
3.1.21.1
uniprot
proteins
function
FUNCTION: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:11241278, PubMed:2251263, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:11241278). Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). {ECO:0000250|UniProtKB:P00639, ECO:0000250|UniProtKB:P21704, ECO:0000250|UniProtKB:P49183, ECO:0000269|PubMed:11241278, ECO:0000269|PubMed:2251263, ECO:0000269|PubMed:2277032}.
uniprot
proteins
mass_dalton
31434
uniprot
proteins
protein_family
DNase I family
uniprot
proteins
pubmed
10381379
uniprot
proteins
pubmed
11241278
uniprot
proteins
pubmed
11479590
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16771825
uniprot
proteins
pubmed
20439745
uniprot
proteins
pubmed
2251263
uniprot
proteins
pubmed
2277032
uniprot
proteins
pubmed
3263467
uniprot
proteins
pubmed
7625762
uniprot
proteins
pubmed
7762978
uniprot
proteins
pubmed
7867802
uniprot
proteins
pubmed
9420147
uniprot
proteins
sequence_length
282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2277032}. Zymogen granule {ECO:0000305}. Nucleus envelope. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope.
uniprot
proteins