CYP2C19
entrez
1557
canonical
uniprot
P33261
canonical
ensembl
ENSG00000165841
resolver
ensp
ENSP00000360372
resolver
enst
ENST00000371321
resolver
genesymbol
CYP2C19
resolver
hgnc
HGNC:2621
resolver
uniprot
P33259
resolver
uniprot
Q8WZB1
resolver
uniprot
Q8WZB2
resolver
uniprot
Q9UCD4
resolver
uniprot_entry
CP2CJ_HUMAN
resolver
uniprot_sec
P33259
resolver
uniprot_sec
Q8WZB1
resolver
uniprot_sec
Q8WZB2
resolver
uniprot_sec
Q9UCD4
resolver
amino_acid_sequence
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
ec_number
1.14.14.51
uniprot
proteins
ec_number
1.14.14.52
uniprot
proteins
ec_number
1.14.14.53
uniprot
proteins
ec_number
1.14.14.75
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position (PubMed:18577768). Catalyzes the epoxidation of double bonds of PUFA (PubMed:19965576, PubMed:20972997). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position (PubMed:23959307). {ECO:0000269|PubMed:11950794, ECO:0000269|PubMed:18577768, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20972997, ECO:0000269|PubMed:23959307}.
uniprot
proteins
mass_dalton
55945
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000269|PubMed:18577768, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20972997}.; PATHWAY: Terpene metabolism; (4R)-limonene degradation. {ECO:0000269|PubMed:11950794}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10022751
uniprot
proteins
pubmed
10411572
uniprot
proteins
pubmed
11950794
uniprot
proteins
pubmed
12464799
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15469410
uniprot
proteins
pubmed
15499191
uniprot
proteins
pubmed
16141610
uniprot
proteins
pubmed
18577768
uniprot
proteins
pubmed
19965576
uniprot
proteins
pubmed
2009263
uniprot
proteins
pubmed
20972997
uniprot
proteins
pubmed
23118231
uniprot
proteins
pubmed
23959307
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28378927
uniprot
proteins
pubmed
7969038
uniprot
proteins
pubmed
8095407
uniprot
proteins
pubmed
8195181
uniprot
proteins
pubmed
8215410
uniprot
proteins
pubmed
9103550
uniprot
proteins
pubmed
9732415
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
uniprot
proteins