Rbck1
entrez
60383
canonical
uniprot
Q62921
canonical
ensembl
ENSRNOG00000006695
resolver
ensp
ENSRNOP00000047637
resolver
ensp
ENSRNOP00000072645
resolver
enst
ENSRNOT00000045314
resolver
enst
ENSRNOT00000085995
resolver
genesymbol
Rbck1
resolver
genesymbol_syn
Pkcbpb15
resolver
genesymbol_syn
Rbck
resolver
genesymbol_syn
Ubce7ip3
resolver
uniprot
A0A0G2K3H9
resolver
uniprot
D4A367
resolver
uniprot
Q9QWN4
resolver
uniprot
Q9Z334
resolver
uniprot_entry
A0A0G2K3H9_RAT
resolver
uniprot_entry
D4A367_RAT
resolver
uniprot_entry
HOIL1_RAT
resolver
uniprot_sec
Q9QWN4
resolver
uniprot_sec
Q9Z334
resolver
amino_acid_sequence
MDEKTKKAEEMALSLARAVTGGDEQAAIKYATWLAEQKVPLRVQVKPEVSPTQDIRLCVSVEDAYMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPSLQQWVVGQRLARDQETLHSHGIRRNGDSAYLYLLSARNTSLNPQELQRQRQLRMLEDLGFKDLTLQPRGPLEPVLPKPRTHQETGQPDAAPESPPVGWQCPGCTFINKPTRPGCEMCCRARPEAYQIPASYQPDEEERARLAGEEEALRQYEQRKQQQQEGNYLQHVQLEQRSLVLNTEPAECPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVSCPFIDNTYSCPGKLLEREIRALLSPEDYQRFLDLGVSIAENRSTLSYHCKTPDCRGWCFFEDDVNEFTCPVCTRVNCLLCKAIHERMNCREYQDDLAHRARNDVAAQQTTEMLRVMLQQGEAMYCPQCRIVVQKKDGCDWIRCTVCHTEICWVTKGPRWGPGGPGDTSGGCRCRVNGIPCHPSCQNCH
uniprot
proteins
ec_number
2.3.2.31
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (By similarity). Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (By similarity). Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:18303026). Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (By similarity). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (By similarity). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (By similarity). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (By similarity). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (By similarity). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (By similarity). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (By similarity). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (By similarity). Binds polyubiquitin of different linkage types (By similarity). {ECO:0000250|UniProtKB:Q9BYM8, ECO:0000269|PubMed:18303026}.
uniprot
proteins
mass_dalton
57685
uniprot
proteins
mutagenesis
MUTAGEN 303; /note="C->G: Greatly reduces auto-ubiquitination."; /evidence="ECO:0000269|PubMed:18303026
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305|PubMed:18303026}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. Auto-ubiquitination leads to degradation by the proteasome. {ECO:0000269|PubMed:18303026}.; PTM: Phosphorylated. In vitro, phosphorylation inhibits auto-ubiquitination activity. {ECO:0000269|PubMed:18303026}.
uniprot
proteins
protein_family
RBR family
uniprot
proteins
pubmed
18303026
uniprot
proteins
pubmed
9514928
uniprot
proteins
pubmed
9755849
uniprot
proteins
sequence_length
508
uniprot
proteins