Q52KF3
uniprot
Q52KF3
canonical
amino_acid_sequence
MANTVEADGSKDEGYEAADEGPEDEDGEKRSISAIRSYQDVMKICAAHLPTESEAPNHYQAVCRALFAETMELHTFLTKIKSAKENLKKIQEMEKGDESSTDLEDLKNADWARFWVQVMRDLRNGVKLKKVQQRQYNPLPIEYQLTPYEMLMDDIRCKRYTLRKVMVNGDVPPRLKKSAHEVILDFIRSRPPLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLVRPLSMSHSFDLSDVTTPESPKNVGESSMVNGGLTSQTKENGLSAAQQGSAQRKRLLKAPTLAELDSSDSEEEKSLHKSTSSSSASPSLYEDPVLEAMCSRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRSLEEFCYPVECLALTVEEVMHIRQVLVKAELEKYQQYKDVYTALKKGKLCFCCRTRRFSFFTWSYTCQFCKRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESCSRSEKPSTSHHRPLRSIARFSTKSRSVDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQSFYMSSAGPSEYCPSERTINEI
uniprot
proteins
function
FUNCTION: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:21983562). Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. In addition, promotes innate immune signaling downstream of dsRNA sensing. Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1. {ECO:0000250|UniProtKB:Q08AE8, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:21983562}.
uniprot
proteins
mass_dalton
68450
uniprot
proteins
protein_family
Spire family
uniprot
proteins
pubmed
15053972
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21620703
uniprot
proteins
pubmed
21983562
uniprot
proteins
sequence_length
598
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21983562}. Cytoplasm, cytosol {ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:21983562}. Cleavage furrow {ECO:0000269|PubMed:21620703}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q08AE8}. Cell membrane {ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:21983562}; Peripheral membrane protein {ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:21983562}; Cytoplasmic side {ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:21983562}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:21983562}; Peripheral membrane protein {ECO:0000269|PubMed:21983562}; Cytoplasmic side {ECO:0000269|PubMed:21983562}. Note=Punctate spots in perinuclear region and cytoplasm, co-localized with Rab11 (PubMed:21983562). Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (PubMed:21620703). {ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:21983562}.
uniprot
proteins