Atad5
entrez
237877
canonical
uniprot
Q4QY64
canonical
ensembl
ENSMUSG00000017550
resolver
ensp
ENSMUSP00000017694
resolver
ensp
ENSMUSP00000103874
resolver
ensp
ENSMUSP00000327773
resolver
enst
ENSMUST00000108239
resolver
genesymbol
Atad5
resolver
genesymbol_syn
Frag1
resolver
uniprot
Q3TMG5
resolver
uniprot
Q3UW85
resolver
uniprot
Q3V306
resolver
uniprot
Q3V3T9
resolver
uniprot
Q5SSK4
resolver
uniprot
Q8BUH4
resolver
uniprot
Q8CGG7
resolver
uniprot
Z4YKQ9
resolver
uniprot_entry
ATAD5_MOUSE
resolver
uniprot_entry
Z4YKQ9_MOUSE
resolver
uniprot_sec
Q3TMG5
resolver
uniprot_sec
Q3UW85
resolver
uniprot_sec
Q3V306
resolver
uniprot_sec
Q3V3T9
resolver
uniprot_sec
Q5SSK4
resolver
uniprot_sec
Q8BUH4
resolver
uniprot_sec
Q8CGG7
resolver
amino_acid_sequence
MVGVLSMAAAAAPLPVKDYEIEPCKKRRKDDDNSSCETITKYLSPIGKTGDKVFSPPKPSNILHYFRKTSLTTEKPQSTKAYKIKPSPPLLVGNSKDCKTPLEVFSNREFKRKRKRVSLSSQLNDIKIQDECPVEISNNDSKEDGGLSDCVESSASVSLYKEHVEVLAESIEDSRNQPNTKSSKKKVNPKQCTTKSDDRILRKRKRSKVTGQSESVPLADELSLPEDGGKDSKLTKPSLAEENDSRTHATKRADLKESTITVSYEEFVKSHKAAKVEEIPDPAVPACVPSGPGEAVKSGSEGELSGSCEPSPQLHLKTVTVLAQVHPTPPKKKGKIPPIFLKQKQPELENSLSDPENEQPVQKRKSNVVIQEGQLELAVLEAWNSEASVPKCSMEERQQFMRAFRQPPPDTLKNGFKKPLEKQKDPSEKSVHEGDSSSEKIIENPNIQRVSSQGCLQSHADRGSFPKEKSKKPNKKGKKTRTTAGGNREENIQKEKTAFSLKDEQDQNSLRRSVRQKSEVLKSNALLNSENLVCEDTAHDSVQMSLCNRNKSRSSSTPTRDMVTHHRAEPGSSLEYVSTRQPIRRSLRSCSTPATNALGGTESEDAQDTIPVKASTPKSARTSEKHNLYTAELIIVSSDSESPIRMKFTRISTPKKSKKSSKKSETTEEELTSQKKKANSTSKNISKAKELIEEAKAFQIGGSKTEETVVPLRRSSRHQARSAKEKSPEIDDSVIVIDSSPTSIREPEKSQKKLQNLNDVLGKKLNKSSKNVPGKMKIAPLFLAKRTKRAAIPVFDLDESSQDSSEQTQDCDVQFKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDEYWLWHLKPPSCPLLTEFKELNTKVTDLSEYVVAFGEFSTLNPNPRSNPAAVMMRTRKDFTKEVRNLLLEEIKCSNPEFSLEKYFPLLLKKRIEHQVLCEGHGKQASPQLQPDVSQKETKRKQVATGNQKSKRKRQNEYSVSPEEMKGRSKDLDERISSSCTNLDPSRDSGTEDMLWTEKYQPQNSNELIGNELAVKKLHSWLKDWKRRAELEERHNLKGKRDEKEEGILDLSDSTDFKGSSDDEENRLCNTVLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQSHQVDKQGVNSQKPCFFNNYNIGKSPKKLNSPGKVVTSPRKLPPSSPKTSGQKRALLPKTLANYFKVSSKSKSNDDVGALMGDDKGVKNSSLEQRQLIQTKSTNANNSHIKDVGAEESNRKKATSLILFEEVDVIFDEDAGFLNAVKTFMATTKRPVILTTSDPTFSLVFDGCFEEINFSIPSLLNVASYLQVICLVENFRTDFKDFVTLLTANACDIRKSILYLQFWIRSGGGILEERPLSHCRENSRNTLVCSEDGSDANINSKKPKRNRVALPRCDTGCAEALFGLKNIASPSQDLLSLLKHKITTKEEWQKLIQVLTEFHVQNIDLLHSNLEVILPLPVHVVPDVRGAYGFPVTTQASAPASMGHLTRKQSKDQPLRKSQKRKQKKMVILDDSDLFDTGLDFSGELPSLSPAPSLSVEDNIRRDSNPEIKTQNSGFKPHSVPQPPKTLAEKKCCMLVSHCLNSLSEFMENMSFIDALLTDPGEQNELGRSAFHWTNGRVKSGLCDEFSLENRDRWAPQSAGELKATAEALSFTECSSTISKALESLNSCKQLERDPTNELTVCVSQRRHDACFRQSAANLDNADKRMAVIKSVFSSRSFLTLGNKQASIIDYLPTLRNICRTEKLKEQEKNKRRFLHYFEGIHLEIPEETITTLAADFP
uniprot
proteins
function
FUNCTION: Has an important role in DNA replication and in maintaining genome integrity during replication stress. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway. As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle. This seems to be dependent on its ATPase activity. Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner. Ultimately this enables replication fork regression, breakage, and eventual fork restart. Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks. Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (By similarity). {ECO:0000250|UniProtKB:Q96QE3, ECO:0000269|PubMed:15983387}.
uniprot
proteins
mass_dalton
203909
uniprot
proteins
post_translational_modification
PTM: ATR may stimulate the RAD9A dissociation. {ECO:0000250}.
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15983387
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1826
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96QE3}. Note=Accumulates in nuclear foci at sites of stalled DNA replication forks in response to DNA damage. {ECO:0000250|UniProtKB:Q96QE3}.
uniprot
proteins