Grid2
entrez
14804
canonical
uniprot
Q61625
canonical
ensembl
ENSMUSG00000071424
resolver
ensp
ENSMUSP00000093536
resolver
enst
ENSMUST00000095852
resolver
genesymbol
Grid2
resolver
uniprot
A4QPG1
resolver
uniprot_entry
GRID2_MOUSE
resolver
uniprot_sec
A4QPG1
resolver
activity_regulation
ACTIVITY REGULATION: Activated by the binding of D-serine or GABA (gamma-aminobutyric acid), which results in the asymmetric opening of the ion channel for conductance (By similarity). Its ligand-gated cation channel activity was previously disputed due to a lack of evidence for direct ligand-gated ion channel activity (PubMed:39052831). {ECO:0000250|UniProtKB:O43424, ECO:0000269|PubMed:39052831}.
uniprot
proteins
amino_acid_sequence
MEVFPLLLFLSFCWSRTWDLATADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSSLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLETWWSRRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFAFGSVPEHRTGPFRHRAPNGGFFRSPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Grid2 are the cause of the Lurcher phenotype. Heterozygous animals display a characteristic swaying of the hind quarters and jerky up and down movements following cerebellar Purkinje cell degeneration during postnatal development. Homozygous animals die shortly after birth because of a massive loss of midbrain and hindbrain neurons during late embryogenesis.
uniprot
proteins
function
FUNCTION: Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system (By similarity). Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand (PubMed:24357660). Promotes synaptogenesis and mediates the D-serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex (By similarity). In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine (PubMed:34936451). Cation-selective ion channel activity can be triggered by GRM1 in Purkinje cells (PubMed:24357660, PubMed:27276689). {ECO:0000250|UniProtKB:O43424, ECO:0000269|PubMed:24357660, ECO:0000269|PubMed:27276689, ECO:0000269|PubMed:34936451}.
uniprot
proteins
mass_dalton
113082
uniprot
proteins
mutagenesis
MUTAGEN 920; /note="S->A: Abolishes interaction with SHANK1 and SHANK2."; /evidence="ECO:0000269|PubMed:15207857
uniprot
proteins
protein_family
GRID2 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
12372286
uniprot
proteins
pubmed
15207857
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17027646
uniprot
proteins
pubmed
20395510
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21410790
uniprot
proteins
pubmed
22220752
uniprot
proteins
pubmed
24357660
uniprot
proteins
pubmed
27276689
uniprot
proteins
pubmed
29782851
uniprot
proteins
pubmed
34936451
uniprot
proteins
pubmed
39052831
uniprot
proteins
pubmed
7506541
uniprot
proteins
pubmed
9285588
uniprot
proteins
sequence_length
1007
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:24357660}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O43424}.
uniprot
proteins
transmembrane_region
TRANSMEM 567..587; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:O43424"; TRANSMEM 625..653; /note="Helical; Name=M3"; /evidence="ECO:0000250|UniProtKB:O43424"; TRANSMEM 831..851; /note="Helical; Name=M4"; /evidence="ECO:0000250|UniProtKB:O43424
uniprot
proteins