DUSP18
entrez
150290
canonical
uniprot
Q8NEJ0
canonical
ensembl
ENSG00000167065
resolver
ensp
ENSP00000333917
resolver
ensp
ENSP00000340795
resolver
ensp
ENSP00000366291
resolver
ensp
ENSP00000384946
resolver
ensp
ENSP00000385463
resolver
ensp
ENSP00000386063
resolver
ensp
ENSP00000536355
resolver
ensp
ENSP00000536356
resolver
ensp
ENSP00000536357
resolver
ensp
ENSP00000536358
resolver
ensp
ENSP00000536359
resolver
ensp
ENSP00000536360
resolver
ensp
ENSP00000536361
resolver
ensp
ENSP00000582662
resolver
ensp
ENSP00000582663
resolver
ensp
ENSP00000635940
resolver
ensp
ENSP00000635941
resolver
ensp
ENSP00000635942
resolver
ensp
ENSP00000635943
resolver
enst
ENST00000334679
resolver
enst
ENST00000377087
resolver
enst
ENST00000403268
resolver
enst
ENST00000404885
resolver
enst
ENST00000407308
resolver
enst
ENST00000866296
resolver
enst
ENST00000866297
resolver
enst
ENST00000866298
resolver
enst
ENST00000866299
resolver
enst
ENST00000866300
resolver
enst
ENST00000866301
resolver
enst
ENST00000866302
resolver
enst
ENST00000912603
resolver
enst
ENST00000912604
resolver
enst
ENST00000965881
resolver
enst
ENST00000965882
resolver
enst
ENST00000965883
resolver
enst
ENST00000965884
resolver
genesymbol
DUSP18
resolver
genesymbol_syn
LMWDSP20
resolver
hgnc
HGNC:18484
resolver
uniprot
B3KPA4
resolver
uniprot
F2Z2P2
resolver
uniprot_entry
DUS18_HUMAN
resolver
uniprot_entry
F2Z2P2_HUMAN
resolver
uniprot_sec
B3KPA4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by manganese ions, inhibited by iodoacetic acid. {ECO:0000269|PubMed:12591617}.
uniprot
proteins
amino_acid_sequence
MTAPSCAFPVQFRQPSVSGLSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLFGKNTVHMVSSPVGMIPDIYEKEVRLMIPL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). In bone tissue, upon activation of the G(q)-dependent KISS1/KISS1R signaling pathway, DUSP18 is recruited to the KISS1R C-terminus where it dephosphorylates SRC, resulting in down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (By similarity). {ECO:0000250|UniProtKB:Q8VE01, ECO:0000269|PubMed:12408986, ECO:0000269|PubMed:12591617}.
uniprot
proteins
mass_dalton
21066
uniprot
proteins
mutagenesis
MUTAGEN 73; /note="D->A: Abolishes most of in vitro phosphatase activity."; /evidence="ECO:0000269|PubMed:12591617"; MUTAGEN 102; /note="L->V: No effect on in vitro phosphatase activity."; /evidence="ECO:0000269|PubMed:12591617"; MUTAGEN 104; /note="C->S: Abolishes most of phosphatase activity. Decreases interaction with SRC. Decreases SRC phosphorylation."; /evidence="ECO:0000269|PubMed:12591617, ECO:0000269|PubMed:38346942"; MUTAGEN 110; /note="R->K: Abolishes most of in vitro phosphatase activity."; /evidence="ECO:0000269|PubMed:12591617"; MUTAGEN 111; /note="S->A: Abolishes most of in vitro phosphatase activity."; /evidence="ECO:0000269|PubMed:12591617
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
12408986
uniprot
proteins
pubmed
12591617
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16699184
uniprot
proteins
pubmed
38346942
uniprot
proteins
pubmed
39702286
uniprot
proteins
sequence_length
188
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12408986}. Nucleus {ECO:0000269|PubMed:12408986}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8VE01}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8VE01}; Intermembrane side {ECO:0000250|UniProtKB:Q8VE01}. Note=Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment. {ECO:0000250|UniProtKB:Q8VE01}.
uniprot
proteins