MCRIP1
entrez
348262
canonical
uniprot
C9JLW8
canonical
ensembl
ENSG00000225663
resolver
ensembl
ENSG00000288213
resolver
ensp
ENSP00000408827
resolver
ensp
ENSP00000409009
resolver
ensp
ENSP00000445543
resolver
ensp
ENSP00000458707
resolver
ensp
ENSP00000458720
resolver
ensp
ENSP00000460299
resolver
ensp
ENSP00000460461
resolver
ensp
ENSP00000461433
resolver
ensp
ENSP00000499966
resolver
ensp
ENSP00000500166
resolver
ensp
ENSP00000500318
resolver
ensp
ENSP00000500382
resolver
ensp
ENSP00000500493
resolver
ensp
ENSP00000500564
resolver
ensp
ENSP00000500656
resolver
ensp
ENSP00000500711
resolver
ensp
ENSP00000576201
resolver
ensp
ENSP00000576204
resolver
ensp
ENSP00000576205
resolver
ensp
ENSP00000576207
resolver
ensp
ENSP00000576208
resolver
ensp
ENSP00000599120
resolver
ensp
ENSP00000599121
resolver
ensp
ENSP00000599122
resolver
ensp
ENSP00000599123
resolver
ensp
ENSP00000599124
resolver
ensp
ENSP00000599125
resolver
ensp
ENSP00000599127
resolver
ensp
ENSP00000623649
resolver
ensp
ENSP00000623650
resolver
ensp
ENSP00000623651
resolver
ensp
ENSP00000623652
resolver
enst
ENST00000455127
resolver
enst
ENST00000457257
resolver
enst
ENST00000538396
resolver
enst
ENST00000572645
resolver
enst
ENST00000573478
resolver
enst
ENST00000574190
resolver
enst
ENST00000575061
resolver
enst
ENST00000576730
resolver
enst
ENST00000671931
resolver
enst
ENST00000672201
resolver
enst
ENST00000672501
resolver
enst
ENST00000672505
resolver
enst
ENST00000672991
resolver
enst
ENST00000673154
resolver
enst
ENST00000673364
resolver
enst
ENST00000673369
resolver
enst
ENST00000906142
resolver
enst
ENST00000906145
resolver
enst
ENST00000906146
resolver
enst
ENST00000906148
resolver
enst
ENST00000906149
resolver
enst
ENST00000929061
resolver
enst
ENST00000929062
resolver
enst
ENST00000929063
resolver
enst
ENST00000929064
resolver
enst
ENST00000929065
resolver
enst
ENST00000929066
resolver
enst
ENST00000929068
resolver
enst
ENST00000953590
resolver
enst
ENST00000953591
resolver
enst
ENST00000953592
resolver
enst
ENST00000953593
resolver
genesymbol
MCRIP1
resolver
genesymbol_syn
FAM195B
resolver
genesymbol_syn
GRAN2
resolver
hgnc
HGNC:28007
resolver
uniprot
A0A024R8W3
resolver
uniprot
I3L3A7
resolver
uniprot
I3L4Q0
resolver
uniprot
Q6ZUL0
resolver
uniprot_entry
I3L3A7_HUMAN
resolver
uniprot_entry
I3L4Q0_HUMAN
resolver
uniprot_entry
MCRI1_HUMAN
resolver
uniprot_sec
A0A024R8W3
resolver
uniprot_sec
Q6ZUL0
resolver
amino_acid_sequence
MTSSPVSRVVYNGKRTSSPRSPPSSSEIFTPAHEENVRFIYEAWQGVERDLRGQVPGGERGLVEEYVEKVPNPSLKTFKPIDLSDLKRRSTQDAKKS
uniprot
proteins
function
FUNCTION: The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771). {ECO:0000269|PubMed:25728771}.
uniprot
proteins
mass_dalton
10920
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by MAPK3/1 (ERK1/2) regulates MCRIP1 binding to CTBP(s) (PubMed:25728771). {ECO:0000269|PubMed:25728771}.
uniprot
proteins
protein_family
MCRIP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25728771
uniprot
proteins
pubmed
26184334
uniprot
proteins
sequence_length
97
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25728771, ECO:0000269|PubMed:26184334}. Cytoplasm, Stress granule {ECO:0000269|PubMed:26184334}.
uniprot
proteins