CKAP4
entrez
10970
canonical
uniprot
Q07065
canonical
ensembl
ENSG00000136026
resolver
ensp
ENSP00000367265
resolver
enst
ENST00000378026
resolver
genesymbol
CKAP4
resolver
hgnc
HGNC:16991
resolver
uniprot
Q504S5
resolver
uniprot
Q53ES6
resolver
uniprot_entry
CKAP4_HUMAN
resolver
uniprot_sec
Q504S5
resolver
uniprot_sec
Q53ES6
resolver
amino_acid_sequence
MPSAKQRGSKGGHGAASPSEKGAHPSGGADDVAKKPPPAPQQPPPPPAPHPQQHPQQHPQNQAHGKGGHRGGGGGGGKSSSSSSASAAAAAAAASSSASCSRRLGRALNFLFYLALVAAAAFSGWCVHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV
uniprot
proteins
function
FUNCTION: Mediates the anchoring of the endoplasmic reticulum to microtubules. {ECO:0000269|PubMed:15703217}.; FUNCTION: High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells. {ECO:0000269|PubMed:17030514, ECO:0000269|PubMed:19144824}.
uniprot
proteins
mass_dalton
66022
uniprot
proteins
post_translational_modification
PTM: Reversibly palmitoylated. Palmitoylation at Cys-100 by ZDHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization. Palmitoylation by ZDHHC2 is also required for its function in APF-mediated antiproliferative signaling (PubMed:19144824). {ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:19144824, ECO:0000269|PubMed:8314870}.; PTM: Increased phosphorylation during mitosis prevents binding to microtubules. {ECO:0000269|PubMed:15703217}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15703217
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17030514
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17567679
uniprot
proteins
pubmed
18296695
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19144824
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
32075961
uniprot
proteins
pubmed
8314870
uniprot
proteins
sequence_length
602
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:19144824}; Single-pass type II membrane protein. Cell membrane {ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:19144824}; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF-stimulation.
uniprot
proteins
transmembrane_region
TRANSMEM 107..127; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins