Pi4kb
entrez
81747
canonical
uniprot
O08561
canonical
ensembl
ENSRNOG00000021024
resolver
ensp
ENSRNOP00000039342
resolver
ensp
ENSRNOP00000082231
resolver
ensp
ENSRNOP00000089657
resolver
ensp
ENSRNOP00000093461
resolver
ensp
ENSRNOP00000095998
resolver
enst
ENSRNOT00000040501
resolver
enst
ENSRNOT00000103639
resolver
enst
ENSRNOT00000112810
resolver
enst
ENSRNOT00000118319
resolver
genesymbol
Pi4kb
resolver
genesymbol_syn
Pik4cb
resolver
uniprot
A0A8I5ZT79
resolver
uniprot
A0A8I6AD21
resolver
uniprot
A0A8I6ALD3
resolver
uniprot
A0A8L2QJX4
resolver
uniprot_entry
A0A8I5ZT79_RAT
resolver
uniprot_entry
A0A8I6AD21_RAT
resolver
uniprot_entry
A0A8I6ALD3_RAT
resolver
uniprot_entry
A0A8L2QJX4_RAT
resolver
uniprot_entry
PI4KB_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by wortmannin (PubMed:8973579). Increased kinase activity upon interaction with NCS1/FREQ (By similarity). {ECO:0000250|UniProtKB:O02810, ECO:0000269|PubMed:8973579}.
uniprot
proteins
amino_acid_sequence
MGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGSPLELVNGDGVDNEIRCLDDPPTEIREEEDEMEPGVVSGTAKGTRRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTNVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
uniprot
proteins
ec_number
2.7.1.67
uniprot
proteins
function
FUNCTION: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP) (PubMed:8973579). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (PubMed:8973579). May play an important role in the inner ear development. {ECO:0000250|UniProtKB:Q9UBF8, ECO:0000269|PubMed:8973579}.
uniprot
proteins
mass_dalton
91655
uniprot
proteins
protein_family
PI3/PI4-kinase family
uniprot
proteins
protein_family
Type III PI4K subfamily
uniprot
proteins
pubmed
11526106
uniprot
proteins
pubmed
19458041
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8973579
uniprot
proteins
sequence_length
816
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:11526106, ECO:0000269|PubMed:19458041, ECO:0000269|PubMed:8973579}. Endomembrane system {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Rough endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9UBF8}. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3, GGA2 is also involved in the recruitment. {ECO:0000250|UniProtKB:Q9UBF8}.
uniprot
proteins