Mdh1
entrez
17449
canonical
uniprot
P14152
canonical
ensembl
ENSMUSG00000020321
resolver
ensp
ENSMUSP00000099938
resolver
ensp
ENSMUSP00000159017
resolver
ensp
ENSMUSP00000159049
resolver
enst
ENSMUST00000102874
resolver
enst
ENSMUST00000238916
resolver
enst
ENSMUST00000239073
resolver
genesymbol
Mdh1
resolver
genesymbol_syn
Mor2
resolver
uniprot
A0A5F8MPN8
resolver
uniprot
Q3TP22
resolver
uniprot
Q80Y13
resolver
uniprot
Q9DB45
resolver
uniprot_entry
A0A5F8MPN8_MOUSE
resolver
uniprot_entry
MDHC_MOUSE
resolver
uniprot_sec
Q3TP22
resolver
uniprot_sec
Q80Y13
resolver
uniprot_sec
Q9DB45
resolver
amino_acid_sequence
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLQDVIATDKEEIAFKDLDVAVLVGSMPRREGMERKDLLKANVKIFKSQGTALEKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKSQIALKLGVTADDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFITTVQQRGAAVIKARKLSSAMSAAKAIADHIRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKETAFEFLSSA
uniprot
proteins
ec_number
1.1.1.37
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS). {ECO:0000250|UniProtKB:P40925}.
uniprot
proteins
mass_dalton
36511
uniprot
proteins
post_translational_modification
PTM: ISGylated. {ECO:0000269|PubMed:16139798}.; PTM: Acetylation at Lys-118 dramatically enhances enzymatic activity and promotes adipogenic differentiation. {ECO:0000250|UniProtKB:P40925}.
uniprot
proteins
protein_family
LDH/MDH superfamily
uniprot
proteins
protein_family
MDH type 2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16139798
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
3172222
uniprot
proteins
pubmed
3312200
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P40925}.
uniprot
proteins