Fgd2
entrez
26382
canonical
uniprot
Q8BY35
canonical
ensembl
ENSMUSG00000024013
resolver
ensp
ENSMUSP00000024810
resolver
ensp
ENSMUSP00000313668
resolver
ensp
ENSMUSP00000313675
resolver
enst
ENSMUST00000024810
resolver
genesymbol
Fgd2
resolver
uniprot
O88841
resolver
uniprot
Q2L9D2
resolver
uniprot
Q3U195
resolver
uniprot
Q7TSE3
resolver
uniprot
Q8VDH4
resolver
uniprot_entry
FGD2_MOUSE
resolver
uniprot_sec
O88841
resolver
uniprot_sec
Q2L9D2
resolver
uniprot_sec
Q3U195
resolver
uniprot_sec
Q7TSE3
resolver
uniprot_sec
Q8VDH4
resolver
amino_acid_sequence
MERACEKQDSVCNLVAVFENNRTPGEAPGSHSLEDQPHSPEHQLSLSPEPWEAPPVKEALKSEFRPVSRTYLSSLKNKLSSGAWRRSCQPGVSPGPETQEPEEKRVVRELLETEQAYVARLHLLDQVFFQELLREAGRSKAFPEDVVKLIFSNISSIYRFHAQFFLPELQRRVDDWAATPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWMDKSQPFQEVVTRIQCSEASSSLTLQHHMLEPVQRIPRYELLLKEYVQKLPAQAPDLEDAQRALDMIFSAAQHSNAAIAEMERLQGLWDVYQRLGLEDDIVDPSNTLLREGPVLKISFRRSDPMERYLVLFNNMLLYCVPRVLQVGAQFQVRTRIDVAGMKVRELTDAEFPHSFLVSGKQRTLELQARSRDEMVSWMQACQAAIDQVEKRSETFKAAVQGPQGDTQEPKPQVEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCAKCSDYRAELKYDSNRPNRVCLTCYTFLTGNVLPQGKEDKRRGILEKEASAAPEQSLVCSFLQLIGDKCSRSLPRSWCVIPRDDPLVLYVYAAPQDTKAHTSIPLLGYQVISGPQGDPRVFQLQQSGQQYTFKAESVELQGRWVTAIKRAASGRTPEGPDEEDVSD
uniprot
proteins
function
FUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. {ECO:0000269|Ref.2}.
uniprot
proteins
mass_dalton
74634
uniprot
proteins
mutagenesis
MUTAGEN 287; /note="S->A: No effect on early endosome localization and reduced JNK1 activation; when associated with A-288."; /evidence="ECO:0000269|Ref.2"; MUTAGEN 288; /note="N->A: No effect on early endosome localization and reduced JNK1 activation; when associated with A-287."; /evidence="ECO:0000269|Ref.2"; MUTAGEN 454; /note="Q->K: Loss of early endosome localization; when associated with T-455."; /evidence="ECO:0000269|Ref.2"; MUTAGEN 455; /note="W->T: Loss of early endosome localization; when associated with K-454."; /evidence="ECO:0000269|Ref.2
uniprot
proteins
pubmed
10458911
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
655
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|Ref.2}. Nucleus {ECO:0000269|Ref.2}. Early endosome {ECO:0000269|Ref.2}. Early endosome membrane {ECO:0000269|Ref.2}. Cell projection, ruffle membrane {ECO:0000269|Ref.2}. Cytoplasm, cytoskeleton {ECO:0000305|Ref.2}. Note=Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides.
uniprot
proteins