Nup98
entrez
269966
canonical
uniprot
Q6PFD9
canonical
ensembl
ENSMUSG00000063550
resolver
ensp
ENSMUSP00000068530
resolver
ensp
ENSMUSP00000147445
resolver
ensp
ENSMUSP00000147454
resolver
ensp
ENSMUSP00000147486
resolver
ensp
ENSMUSP00000148115
resolver
ensp
ENSMUSP00000212336
resolver
ensp
ENSMUSP00000212338
resolver
ensp
ENSMUSP00000212339
resolver
ensp
ENSMUSP00000212341
resolver
ensp
ENSMUSP00000212346
resolver
ensp
ENSMUSP00000212347
resolver
ensp
ENSMUSP00000326515
resolver
ensp
ENSMUSP00000326516
resolver
ensp
ENSMUSP00000326517
resolver
ensp
ENSMUSP00000326518
resolver
enst
ENSMUST00000070165
resolver
enst
ENSMUST00000210682
resolver
enst
ENSMUST00000211005
resolver
enst
ENSMUST00000211022
resolver
enst
ENSMUST00000211235
resolver
genesymbol
Nup98
resolver
uniprot
A0A140T8J8
resolver
uniprot
A0A1B0GRA7
resolver
uniprot
A0A1B0GRB5
resolver
uniprot
A0A1B0GRE3
resolver
uniprot
A0A1B0GSX7
resolver
uniprot
B2RQL0
resolver
uniprot
Q3TPG3
resolver
uniprot
Q3UJE5
resolver
uniprot
Q4FZE7
resolver
uniprot
Q68G59
resolver
uniprot_entry
A0A140T8J8_MOUSE
resolver
uniprot_entry
A0A1B0GRA7_MOUSE
resolver
uniprot_entry
A0A1B0GRB5_MOUSE
resolver
uniprot_entry
A0A1B0GRE3_MOUSE
resolver
uniprot_entry
A0A1B0GSX7_MOUSE
resolver
uniprot_entry
B2RQL0_MOUSE
resolver
uniprot_entry
NUP98_MOUSE
resolver
uniprot_entry
Q3TPG3_MOUSE
resolver
uniprot_entry
Q3UJE5_MOUSE
resolver
uniprot_entry
Q4FZE7_MOUSE
resolver
uniprot_sec
Q68G59
resolver
amino_acid_sequence
MFNKSFGTPFGGSTGGFGTTSTFGQNTGFGTTSGGAFGTSAFGSSNNTGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGFGTSTGTSNSLFGTASTGTSLFSSQNNAFAQNKPTGFGNFGTSTSSGGLFGTTNTTSNPFGSTSGSLFGPSSFTAAPTGTTIKFNPPTGTDTMVKAGVSTNISTKHQCITAMKEYESKSLEELRLEDYQANRKGPQNQVGGGTTAGLFGSSPATSSATGLFSSSTTNSAFSYGQNKTAFGTSTTGFGTNPGGLFGQQNQQTTSLFSKPFGQATTTPNTGFSFGNTSTLGQPSTNTMGLFGVTQASQPGGLFGTATNTSTGTAFGTGTGLFGQPNTGFGAVGSTLFGNNKLTTFGTSTTSAPSFGTTSGGLFGNKPTLTLGTNTNTSNFGFGTNNSGSSIFGSKPAAGTLGTGLGTGFGTALGAGQASLFGNNQPKIGGPLGTGAFGAPGFNTSTAILGFGAPQAPVALTDPNASAAQQAVLQQHLNSLTYSPFGDSPLFRNPMSDPKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVNHDSEDLASPSEYPENGERFSFLSKPVDENNQQDGEDDSLVSRFYTNPIAKPIPQTPESVGNKNNSSSNVEDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENNAYHIHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPPKTTSKKLKTAPLPPAGQATTFQMTLNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVPDSVLEESVPEDQEPVSASTHIASSLGINPHVLQIMKASLLVDEEDVDAMDQRFGHIPSKGETVQEICSPRLPISASHSSKSRSIVGGLLQSKFASGTFLSPSASVQECRTPRTSSRMNIPSTSPWSVPLPLATVFTVPSPAPEVQLKTVGIRRQPGLVPLEKSITYGKGKLLMDMALFMGRSFRVGWGPNWTLANSGEQLHGSHELENHQVADSMEYGFLPNPVAVKSLSESPFKVHLEKLGLRQRKLDEDLQLYQTPLELKLKHSTVHVDELCPLIVPNPGVSVIHDYADWVKDSPGDFLELPIVKHWSLTWTLCEALWGHLKELDGQLDEPSEYIQTLERRRAFSRWLSHTAAPQIEEEVSLTRRDSPVEAVFSYLTGSRISGACCLAQQSGDHRLALLLSQLVGSQSVRELLTMQLADWHQLQADSFIHDERLRIFALLAGKPVWQLSEQKQINVCSQLDWKRTLAIHLWYLLPPTASISRALSMYEEAFQNTPEGDKYACSPLPSYLEGCGCMVEEEKDSRRPLQDVCFHLLKLYSDRHYELNQLLEPRSITADPLDYRLSWHLWEVLRALNYTHLSEQCEGVLQASYAGQLESEGLWEWAIFVFLHIDNSGMREKAVRELLTRHCQLSETPESWAKEAFLTQKLCVPAEWIHEAKAVRAHMESNKHLEALYLFKAGHWNRCHKLVIRHLASDAIINENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLDYIRVIEMLHRIQQVDCSGYELEHLHTKVTSLCNRIEQIPCYNAKDRLAQSDMAKRVANLLRVVLSLQHAPDATSNSTPDPQRVPLRLLAPHIGRLPMPEDYALEELRGLTQSYLRELTVGSQ
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body). {ECO:0000250|UniProtKB:P52948}.
uniprot
proteins
mass_dalton
197241
uniprot
proteins
mutagenesis
MUTAGEN 831; /note="K->A: Reduces interaction with NUP88."; /evidence="ECO:0000269|PubMed:22480613
uniprot
proteins
post_translational_modification
PTM: Autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively. Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96. {ECO:0000250|UniProtKB:P52948}.
uniprot
proteins
protein_family
Nucleoporin GLFG family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22480613
uniprot
proteins
sequence_length
1816
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:P52948}; Peripheral membrane protein {ECO:0000250|UniProtKB:P52948}; Nucleoplasmic side {ECO:0000250|UniProtKB:P52948}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P52948}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P52948}. Note=Localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket. Dissociates from the disassembled NPC structure early during prophase of mitosis. Colocalized with NUP153 and TPR to the nuclear basket of NPC. Colocalized with DHX9 in diffuse and discrete intranuclear foci (GLFG-body). Remains localized to the nuclear membrane after poliovirus (PV) infection. {ECO:0000250|UniProtKB:P52948}.
uniprot
proteins