ATRAID
entrez
51374
canonical
uniprot
Q6UW56
canonical
ensembl
ENSG00000138085
resolver
ensp
ENSP00000369518
resolver
ensp
ENSP00000384033
resolver
genesymbol
ATRAID
resolver
genesymbol_syn
APR3
resolver
genesymbol_syn
C2orf28
resolver
hgnc
HGNC:24090
resolver
uniprot
A8C1S2
resolver
uniprot
A8K779
resolver
uniprot
Q96FF6
resolver
uniprot
Q96RT2
resolver
uniprot
Q9Y2R7
resolver
uniprot
Q9Y5L7
resolver
uniprot_entry
ARAID_HUMAN
resolver
uniprot_sec
A8C1S2
resolver
uniprot_sec
A8K779
resolver
uniprot_sec
Q96FF6
resolver
uniprot_sec
Q96RT2
resolver
uniprot_sec
Q9Y2R7
resolver
uniprot_sec
Q9Y5L7
resolver
amino_acid_sequence
MAPHDPGSLTTLVPWAAALLLALGVERALALPEICTQCPGSVQNLSKVAFYCKTTRELMLHARCCLNQKGTILGLDLQNCSLEDPGPNFHQAHTTVIIDLQANPLKGDLANTFRGFTQLQTLILPQHVNCPGGINAWNTITSYIDNQICQGQKNLCNNTGDPEMCPENGSCVPDGPGLLQCVCADGFHGYKCMRQGSFSLLMFFGILGATTLSVSILLWATQRRKAKTS
uniprot
proteins
function
FUNCTION: Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphosphonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol (PubMed:29745899). {ECO:0000269|PubMed:21723284, ECO:0000269|PubMed:29745899}.
uniprot
proteins
mass_dalton
24747
uniprot
proteins
pubmed
10948432
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17387583
uniprot
proteins
pubmed
17524364
uniprot
proteins
pubmed
21723284
uniprot
proteins
pubmed
29745899
uniprot
proteins
sequence_length
229
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:21723284}. Cell membrane {ECO:0000269|PubMed:17524364}; Single-pass membrane protein {ECO:0000269|PubMed:17524364}. Lysosome membrane {ECO:0000269|PubMed:29745899}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with NELL1 on the nuclear envelope and the perinuclear region (PubMed:21723284).
uniprot
proteins
transmembrane_region
TRANSMEM 200..220; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins