Cpsf7
entrez
269061
canonical
uniprot
Q8BTV2
canonical
ensembl
ENSMUSG00000034820
resolver
ensp
ENSMUSP00000038958
resolver
ensp
ENSMUSP00000323132
resolver
ensp
ENSMUSP00000323146
resolver
ensp
ENSMUSP00000323148
resolver
genesymbol
Cpsf7
resolver
uniprot
Q3TNF1
resolver
uniprot
Q8BKE7
resolver
uniprot
Q8CFS8
resolver
uniprot_entry
CPSF7_MOUSE
resolver
uniprot_sec
Q3TNF1
resolver
uniprot_sec
Q8BKE7
resolver
uniprot_sec
Q8CFS8
resolver
amino_acid_sequence
MSEGVDLIDIYADEEFNQDSEFNNTDQIDLYDDVLTAASQPSDDRSSSTEPPPPVRQEPAPKPNNKTPAILYTYSGLRSRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASTPYNHHGSRDSGPPPSTVSEAEFEEIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH
uniprot
proteins
function
FUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF7 activates directly the mRNA 3'-processing machinery. Binds to pA signals in RNA substrates. {ECO:0000250|UniProtKB:Q8N684}.
uniprot
proteins
mass_dalton
52011
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q8N684}.; PTM: Asymmetrically dimethylated on arginine residues by PRMT1. {ECO:0000250|UniProtKB:Q8N684}.
uniprot
proteins
protein_family
RRM CPSF6/7 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
471
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N684}. Cytoplasm {ECO:0000250|UniProtKB:Q8N684}. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm). {ECO:0000250|UniProtKB:Q8N684}.
uniprot
proteins