ABCE1
entrez
6059
canonical
uniprot
P61221
canonical
ensembl
ENSG00000164163
resolver
ensp
ENSP00000296577
resolver
ensp
ENSP00000606124
resolver
enst
ENST00000296577
resolver
enst
ENST00000936065
resolver
genesymbol
ABCE1
resolver
genesymbol_syn
RLI
resolver
genesymbol_syn
RNASEL1
resolver
genesymbol_syn
RNASELI
resolver
genesymbol_syn
RNS4I
resolver
hgnc
HGNC:69
resolver
uniprot
O88793
resolver
uniprot
Q13181
resolver
uniprot
Q13864
resolver
uniprot
Q6NR76
resolver
uniprot
Q96AL0
resolver
uniprot
Q96B10
resolver
uniprot
Q99K66
resolver
uniprot_entry
ABCE1_HUMAN
resolver
uniprot_sec
O88793
resolver
uniprot_sec
Q13181
resolver
uniprot_sec
Q13864
resolver
uniprot_sec
Q6NR76
resolver
uniprot_sec
Q96AL0
resolver
uniprot_sec
Q96B10
resolver
uniprot_sec
Q99K66
resolver
amino_acid_sequence
MADKLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQSKIAWISETLCIGCGICIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVTMPFSVREGINIFLDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKSTGSVRQLLHEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLEITFRRDPNNYRPRINKLNSIKDVEQKKSGNYFFLDD
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (PubMed:20122402, PubMed:21448132). Able to hydrolyze ATP, GTP, UTP and CTP (PubMed:20122402). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (PubMed:20122402, PubMed:21448132). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (PubMed:20122402, PubMed:21448132). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (PubMed:29861391). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:9660177). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (PubMed:11585831, PubMed:9660177, PubMed:9847332). {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:20122402, ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. {ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections. {ECO:0000269|PubMed:9660177}.
uniprot
proteins
mass_dalton
67314
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="K->R: Abolishes ubiquitination by CNOT4 and diminished the ability to recruit autophagy receptors to damaged mitochondria and to nuclear encoded respiratory chain component mRNA-ribonucleoproteins complexes."; /evidence="ECO:0000269|PubMed:29861391
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by CNOT4 (PubMed:29861391). Ubiquitination mediates the recruitment of autophagy receptors to the mitochondrial outer membrane and initiates mitophagy (PubMed:29861391). {ECO:0000269|PubMed:29861391}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCE family
uniprot
proteins
pubmed
11585831
uniprot
proteins
pubmed
11780123
uniprot
proteins
pubmed
14747530
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17488105
uniprot
proteins
pubmed
20122402
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21448132
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944354
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29861391
uniprot
proteins
pubmed
7539425
uniprot
proteins
pubmed
8641422
uniprot
proteins
pubmed
9660177
uniprot
proteins
pubmed
9847332
uniprot
proteins
sequence_length
599
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11585831}. Mitochondrion {ECO:0000269|PubMed:11585831}.
uniprot
proteins