Mims1
entrez
307343
canonical
uniprot
Q5XIJ4
canonical
ensembl
ENSRNOG00000080800
resolver
ensembl
ENSRNOG00055010552
resolver
ensembl
ENSRNOG00060009292
resolver
ensembl
ENSRNOG00065023196
resolver
ensp
ENSRNOP00000105562
resolver
ensp
ENSRNOP00055014395
resolver
ensp
ENSRNOP00060012202
resolver
ensp
ENSRNOP00065032216
resolver
enst
ENSRNOT00000139091
resolver
enst
ENSRNOT00055017872
resolver
enst
ENSRNOT00060015657
resolver
enst
ENSRNOT00065039624
resolver
genesymbol
Mims1
resolver
genesymbol_syn
Fam210a
resolver
uniprot_entry
MIMS1_RAT
resolver
amino_acid_sequence
MQWNVPRTMSRLALRTFLEAQKARLFDHHRSTKGLLLVHRGEYRVAWTPHLRKQWLHLSAVQCLAKQRNLLDAQPPQRGALPQGRWEQDILSKRVLSSSSTSQETPSEKKEEPDPLQDKSISLYQRFKKTFRQYGKVLIPVHLITSGIWFGTFYYASIKGVNVIPFLEFLGLPDSVVDILKNSQSGNALTAYAMFKIATPARYTVTLGGTSFTVKYLRSHGYMSTPPPVKEYLQGRMEETKELISEKMEETKDRLTEKLQETKEKVSFKKKVE
uniprot
proteins
function
FUNCTION: Mitochondrial inner membrane protein essential for mitochondrial homeostasis, structural integrity, and cellular metabolism. Regulates mitochondrial translation by modulating protein synthesis of mitochondrial DNA-encoded genes. Plays a critical role in skeletal muscle mass and strength by regulating mitochondrial density, function, and protein synthesis. In brown adipose tissue, regulates mitochondrial cristae remodeling in response to cold stress by interacting with mitochondrial protease YME1L1 and enhancing its proteolytic activity, promoting OMA1 degradation and regulating OPA1 processing. Required for cardiac mitochondrial homeostasis and normal cardiomyocyte contractile function. In skeletal muscle, positively regulates myoblast differentiation by enhancing expression of myogenic factors. {ECO:0000250|UniProtKB:Q8BGY7}.
uniprot
proteins
mass_dalton
31474
uniprot
proteins
protein_family
MIMS family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8BGY7}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8BGY7}.
uniprot
proteins
transmembrane_region
TRANSMEM 138..158; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins