Drd1
entrez
13488
canonical
uniprot
Q61616
canonical
ensembl
ENSMUSG00000021478
resolver
ensp
ENSMUSP00000021932
resolver
ensp
ENSMUSP00000240672
resolver
enst
ENSMUST00000021932
resolver
genesymbol
Drd1
resolver
genesymbol_syn
Drd1a
resolver
genesymbol_syn
Gpcr15
resolver
uniprot
B2RPW8
resolver
uniprot
Q8C8P8
resolver
uniprot_entry
DRD1_MOUSE
resolver
uniprot_sec
B2RPW8
resolver
uniprot_sec
Q8C8P8
resolver
amino_acid_sequence
MAPNTSTMDETGLPVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPVECSQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVMFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKREEAGGIPKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (PubMed:39415006, PubMed:40335693, PubMed:7954836, PubMed:8001143). Dopamine binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). Dopamine receptors can be classified in two categories: (1) DRD1 (together with DRD5) is a D1-type receptor and is coupled to G(s) G proteins, mediating activation of adenylate cyclase activity, while D2-type receptors (DRD2, DRD3 and DRD4) are coupled to G(i)/G(o) G proteins and promote inhibition of adenylate cyclase activity (By similarity). D1- and D2-type dopamine receptors have antagonistic effects, particularly in the brain's striatum, where they govern voluntary movement and reward: D1-type receptors generally stimulate neural activity and promotes action, while D2-type receptors tend to inhibit neural activity and suppress movement (PubMed:39415006, PubMed:40335693). DRD1 acts as an essential regulator of reward, motor activity and cognition in the central nervous system and play beneficial roles in peripheral tissues including inhibiting inflammatory reactions and maintaining cardiovascular and kidney homeostasis (PubMed:39415006, PubMed:40335693, PubMed:7954836, PubMed:8001143). DRD1 and DRD2 are the most abundant dopamine receptors in the central nervous system, especially in the basal ganglia and the prefrontal cortex (By similarity). DRD1 can also couple with G(q) by forming a heteromer with the ghrelin receptor GHSR in hippocampal neurons independently of ghrelin (PubMed:26590421). Following DRD1 activation by dopamine, GHSR acts as a coreceptor promoting DRD1 coupling to G(q) at the expense of G(s), initiating hippocampal synaptic plasticity involved in memory and learning (PubMed:26590421). Forms heterotetramers with DRD3 to potentiate beta-arrestin recruitment and mediate locomotor activity (PubMed:40523512). {ECO:0000250|UniProtKB:P21728, ECO:0000269|PubMed:26590421, ECO:0000269|PubMed:39415006, ECO:0000269|PubMed:40335693, ECO:0000269|PubMed:40523512, ECO:0000269|PubMed:7954836, ECO:0000269|PubMed:8001143}.
uniprot
proteins
mass_dalton
49612
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-256, Ser-258 and Ser-259 by GRK2 and GRK3 following prolonged stimulation by dopamine, promoting association with beta-arrestin (ARRB1 or ARRB2), leading to receptor desensitization and negative regulation of G protein-coupled receptor signaling (By similarity). Phosphorylated at Thr-428 and Ser-431 by GRK4 in the absence of dopamine activation, resulting in constitutive desensitization (By similarity). Constitutive phosphorylation (in absence of dopamine activation) by some isoforms of PKC (PRKCA, PRKCB, PRKCE and PRKCG) inhibits G protein-coupled receptor signaling (By similarity). {ECO:0000250|UniProtKB:P18901, ECO:0000250|UniProtKB:P21728}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11172752
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25865831
uniprot
proteins
pubmed
26590421
uniprot
proteins
pubmed
37248637
uniprot
proteins
pubmed
39415006
uniprot
proteins
pubmed
40335693
uniprot
proteins
pubmed
40523512
uniprot
proteins
pubmed
7954836
uniprot
proteins
pubmed
8001143
uniprot
proteins
pubmed
8288218
uniprot
proteins
pubmed
9692749
uniprot
proteins
sequence_length
446
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P21728}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendritic spine membrane {ECO:0000269|PubMed:25865831}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:P21728}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P18901}; Multi-pass membrane protein {ECO:0000255}. Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. {ECO:0000250|UniProtKB:P18901}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..45; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P21728"; TRANSMEM 61..82; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P21728"; TRANSMEM 96..118; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P21728"; TRANSMEM 139..160; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P21728"; TRANSMEM 193..215; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P21728"; TRANSMEM 273..294; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P21728"; TRANSMEM 311..333; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P21728
uniprot
proteins