Gprc6a
entrez
294394
canonical
uniprot
Q70VB1
canonical
ensembl
ENSRNOG00000000401
resolver
ensembl
ENSRNOG00055015033
resolver
ensembl
ENSRNOG00060007836
resolver
ensembl
ENSRNOG00065003223
resolver
ensp
ENSRNOP00000000451
resolver
ensp
ENSRNOP00055020984
resolver
ensp
ENSRNOP00060009806
resolver
ensp
ENSRNOP00065003261
resolver
enst
ENSRNOT00000000451
resolver
enst
ENSRNOT00055025717
resolver
enst
ENSRNOT00060012928
resolver
enst
ENSRNOT00065004560
resolver
genesymbol
Gprc6a
resolver
uniprot_entry
GPC6A_RAT
resolver
amino_acid_sequence
MALSFVFITCFMILLDTSQSCHTPDDFVAITSPGHIMIGGLFAIHEKMLSSDDHPRQPQIQKCVGFEISVFLQTLAMIHSIEMINNSSLLSGVKLGYEIYDTCTEVTAAMAATLRFLSKFNCSRETVIFQCDYSSYVPRVKAIIGAGYSEISMAVSRMLNLQLMPQVSYESTAEILSDKIRFPSFLRTVPSDFYQTKAMAHLIRQSGWNWVGAITTDDDYGRLALNTFAIQAAENNVCIAFKEVLPAFLSDNTIEVRINQTLEKIIAEAQVNVIVVFLRKFHVFNLFNKAIERKISKIWIASDNWSTAAKIITIPNVKKLGKVVGFTFRRGNMSSFHSFLQTLHMYPSDNNKPLHEFAMLFSACKHIKDGDLSQCISNYSQATWTYDTTKTIETHLFKRNDFLWHYTEPGLIHSIQLAVLALGHAIRDLCQDRDCQKPNAFQPWELLAVLKNVTFTDGKNSFHFDAHGDLNTGYEVVLWKETNGLMTVTKMAEYDLQHDVFITTNQETKHEFRKLKQILSKCSKECIPGQMKKATGSQHSCCYECVNCPENHYSNETDMDHCLVCNNETHWAPVRSTMCFEKEVEYLDWDDSLALLLIALSLLGIAFVLAVGIIFTRNLKTPVVKSSGGLVVCYVMLACHALNFASTGFFIGEPQDFTCKTRQTLFGVSFTLCVSCILTKSLKILLAFSFDPTLKTFLKCLYRPVPIVLTCTGIQVVICTLWLVLAAPTVEENTSLPRVIILECEEGSALAFGTMLGYIAVLAFICFVFAFKGRKLPENYNEAKFLTFGMLIYFIAWITFIPVYATTFGKYLPAVEIIVILISNYGILCCTFFPKCYIILCKQKTNTKSVFLQMVYNYSAHSVDSLALSHVSLDSASHSTATTNPRPGNKTAACQNYKHLPVQVLAHTGMEKTMHASKTLHQKRSSSI
uniprot
proteins
function
FUNCTION: Receptor activated by multiple ligands, including osteocalcin (BGLAP), basic amino acids, and various cations (By similarity). Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids (PubMed:17478059). The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+) (By similarity). Seems to act through a G(q)/G(11) and G(i)-coupled pathway (By similarity). Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (By similarity). Mediates the non-genomic effects of androgens in multiple tissue (By similarity). May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (By similarity). {ECO:0000250|UniProtKB:Q8K4Z6, ECO:0000269|PubMed:17478059}.
uniprot
proteins
mass_dalton
104353
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:17478059}.
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
pubmed
17478059
uniprot
proteins
sequence_length
928
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17478059}; Multi-pass membrane protein {ECO:0000269|PubMed:17478059}.
uniprot
proteins
transmembrane_region
TRANSMEM 595..615; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 631..651; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 670..690; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 707..727; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 751..771; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 785..805; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 813..833; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins