Ap1g1
entrez
11765
canonical
uniprot
P22892
canonical
ensembl
ENSMUSG00000031731
resolver
ensp
ENSMUSP00000034171
resolver
ensp
ENSMUSP00000090844
resolver
enst
ENSMUST00000034171
resolver
enst
ENSMUST00000093157
resolver
genesymbol
Ap1g1
resolver
genesymbol_syn
Adtg
resolver
genesymbol_syn
Clapg1
resolver
uniprot
F8WHW0
resolver
uniprot
Q8CBB7
resolver
uniprot_entry
AP1G1_MOUSE
resolver
uniprot_entry
F8WHW0_MOUSE
resolver
uniprot_entry
Q8CBB7_MOUSE
resolver
amino_acid_sequence
MPAPIRLRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAHFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLTEMCERSPDMLAHFRKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIKSESGLRVLAINILGRFLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKELLYFLDSCEPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCIGEYGDLLVSGQCEEEEPIQVTEDEVLDILESVLISNMSTSVTRGYALTAIMKLSTRFTCTVNRIKKVVSIYGSSIDVELQQRAVEYNALFKKYDHMRSALLERMPVMEKVTTNGPSEIVQTNGETEPAPLETKPPPSGPQPTSQANDLLDLLGGNDITPVIPTAPTSKPASAGGELLDLLGDITLTGAPAAAPTPASVPQISQPPFLLDGLSSQPLFNDIAPGIPSITAYSKNGLKIEFTFERSNTNPSVTVITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSVVPAFNTGTITQVIKVLNPQKQQLRMRIKLTYNHKGSAMQDLAEVNNFPPQSWQ
uniprot
proteins
function
FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes (PubMed:36261523). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (PubMed:36261523). In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity). {ECO:0000250|UniProtKB:O43747, ECO:0000269|PubMed:36261523}.
uniprot
proteins
mass_dalton
91350
uniprot
proteins
mutagenesis
MUTAGEN 753; /note="A->D: Strongly reduces interaction with EPS15 and SYNRG."; /evidence="ECO:0000269|PubMed:12176391"; MUTAGEN 762; /note="L->E: Strongly reduces interaction with EPS15 and SYNRG."; /evidence="ECO:0000269|PubMed:12176391"; MUTAGEN 765; /note="P->N: Reduces interaction with EPS15 and SYNRG."; /evidence="ECO:0000269|PubMed:12176391
uniprot
proteins
protein_family
Adaptor complexes large subunit family
uniprot
proteins
pubmed
12176391
uniprot
proteins
pubmed
15377783
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2126014
uniprot
proteins
pubmed
36261523
uniprot
proteins
sequence_length
822
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:O43747}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:O43747}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43747}; Cytoplasmic side {ECO:0000250|UniProtKB:O43747}. Cytoplasm {ECO:0000250|UniProtKB:O43747}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O43747}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:O43747}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:O43747}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (By similarity). Co-localizes with AFTPH/aftiphilin in the cytoplasm (By similarity). {ECO:0000250|UniProtKB:O43747}.
uniprot
proteins