CXADR
entrez
1525
canonical
uniprot
P78310
canonical
ensembl
ENSG00000154639
resolver
ensp
ENSP00000284878
resolver
ensp
ENSP00000348620
resolver
ensp
ENSP00000383029
resolver
ensp
ENSP00000383030
resolver
ensp
ENSP00000383033
resolver
ensp
ENSP00000776700
resolver
ensp
ENSP00000798384
resolver
genesymbol
CXADR
resolver
genesymbol_syn
CAR
resolver
hgnc
HGNC:2559
resolver
uniprot
B2R8V8
resolver
uniprot
B7WPI3
resolver
uniprot
D3YHP0
resolver
uniprot
O00694
resolver
uniprot
Q8WWT6
resolver
uniprot
Q8WWT7
resolver
uniprot
Q8WWT8
resolver
uniprot
Q9UKV4
resolver
uniprot_entry
CXAR_HUMAN
resolver
uniprot_sec
B2R8V8
resolver
uniprot_sec
B7WPI3
resolver
uniprot_sec
D3YHP0
resolver
uniprot_sec
O00694
resolver
uniprot_sec
Q8WWT6
resolver
uniprot_sec
Q8WWT7
resolver
uniprot_sec
Q8WWT8
resolver
uniprot_sec
Q9UKV4
resolver
amino_acid_sequence
MALLLCFVLLCGVVDFARSLSITTPEEMIEKAKGETAYLPCKFTLSPEDQGPLDIEWLISPADNQKVDQVIILYSGDKIYDDYYPDLKGRVHFTSNDLKSGDASINVTNLQLSDIGTYQCKVKKAPGVANKKIHLVVLVKPSGARCYVDGSEEIGSDFKIKCEPKEGSLPLQYEWQKLSDSQKMPTSWLAEMTSSVISVKNASSEYSGTYSCTVRNRVGSDQCLLRLNVVPPSNKAGLIAGAIIGTLLALALIGLIIFCCRKKRREEKYEKEVHHDIREDVPPPKSRTSTARSYIGSNHSSLGSMSPSNMEGYSKTQYNQVPSEDFERTPQSPTLPPAKVAAPNLSRMGAIPVMIPAQSKDGSIV
uniprot
proteins
function
FUNCTION: Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:10567268, ECO:0000269|PubMed:10666333, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:9733828}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. {ECO:0000269|PubMed:10814575, ECO:0000269|PubMed:14978041}.
uniprot
proteins
mass_dalton
40030
uniprot
proteins
mutagenesis
MUTAGEN 70..72; /note="VII->AID: Abolishes binding to adenovirus type 5."; /evidence="ECO:0000269|PubMed:10666333"; MUTAGEN 259..260; /note="CC->AA: Loss of palmitoylation and altered localization."; /evidence="ECO:0000269|PubMed:12021372"; MUTAGEN 318; /note="Y->A: Affects basolateral localization in airway epithelial cells."; /evidence="ECO:0000269|PubMed:11316797"; MUTAGEN 345..348; /note="LSRM->AAAA: Affects basolateral localization in airway epithelial cells."; /evidence="ECO:0000269|PubMed:11316797
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250}.; PTM: Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane. {ECO:0000269|PubMed:12021372}.
uniprot
proteins
pubmed
10490761
uniprot
proteins
pubmed
10543405
uniprot
proteins
pubmed
10567268
uniprot
proteins
pubmed
10666333
uniprot
proteins
pubmed
10814575
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
11080637
uniprot
proteins
pubmed
11316797
uniprot
proteins
pubmed
11457744
uniprot
proteins
pubmed
11549277
uniprot
proteins
pubmed
11573093
uniprot
proteins
pubmed
11734628
uniprot
proteins
pubmed
12021372
uniprot
proteins
pubmed
12297051
uniprot
proteins
pubmed
12468544
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14967025
uniprot
proteins
pubmed
14978041
uniprot
proteins
pubmed
15304526
uniprot
proteins
pubmed
15364909
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15533241
uniprot
proteins
pubmed
15800062
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19064666
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9036860
uniprot
proteins
pubmed
9096397
uniprot
proteins
pubmed
9733828
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15533241}; Single-pass type I membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:11316797, ECO:0000269|PubMed:12021372, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15364909}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051}. Cell junction, adherens junction {ECO:0000269|PubMed:12297051}. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797). {ECO:0000269|PubMed:11316797, ECO:0000269|PubMed:12297051}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:14978041}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000269|PubMed:14978041}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted {ECO:0000269|PubMed:14978041}.
uniprot
proteins
transmembrane_region
TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins