Reg3b
entrez
24618
canonical
uniprot
P25031
canonical
ensembl
ENSRNOG00000006151
resolver
ensp
ENSRNOP00000008212
resolver
enst
ENSRNOT00000008212
resolver
genesymbol
Reg3b
resolver
genesymbol_syn
Pap
resolver
genesymbol_syn
Pap1
resolver
genesymbol_syn
Reg2
resolver
uniprot
A0A0H2UHE4
resolver
uniprot
Q64102
resolver
uniprot
Q64231
resolver
uniprot_entry
A0A0H2UHE4_RAT
resolver
uniprot_entry
REG3B_RAT
resolver
uniprot_sec
Q64102
resolver
uniprot_sec
Q64231
resolver
activity_regulation
ACTIVITY REGULATION: [Regenerating islet-derived protein 3-beta 15 kDa form]: Lipopolysaccharide inhibits pore-forming activity, explaining why is bactericidal for Gram-positive but not Gram-negative bacteria. {ECO:0000250|UniProtKB:Q06141}.
uniprot
proteins
amino_acid_sequence
MLHRLAFPVMSWMLLSCLMLLSQVQGEDSPKKIPSARISCPKGSQAYGSYCYALFQIPQTWFDAELACQKRPEGHLVSVLNVAEASFLASMVKNTGNSYQYTWIGLHDPTLGGEPNGGGWEWSNNDIMNYVNWERNPSTALDRGFCGSLSRSSGFLRWRDTTCEVKLPYVCKFTG
uniprot
proteins
disease_involvement
DISEASE: Note=Overexpressed during the acute phase of pancreatitis.
uniprot
proteins
function
FUNCTION: Bactericidal C-type lectin which acts against several intestinal Gram-positive bacteria and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues. {ECO:0000250|UniProtKB:P35230}.; FUNCTION: Acts as a hormone in response to different stimuli. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. In pancreas, is able stimulate cell proliferation. {ECO:0000250|UniProtKB:P35230}.
uniprot
proteins
mass_dalton
19617
uniprot
proteins
post_translational_modification
PTM: Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. {ECO:0000250|UniProtKB:P35230}.
uniprot
proteins
pubmed
1511905
uniprot
proteins
pubmed
1722211
uniprot
proteins
pubmed
7895644
uniprot
proteins
pubmed
8238345
uniprot
proteins
pubmed
8314803
uniprot
proteins
sequence_length
175
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P35230}. Note=Found in the apical region of pancreatic acinar cells. {ECO:0000250|UniProtKB:P35230}.
uniprot
proteins