Nlgn2
entrez
216856
canonical
uniprot
Q69ZK9
canonical
ensembl
ENSMUSG00000051790
resolver
ensp
ENSMUSP00000053097
resolver
ensp
ENSMUSP00000104274
resolver
enst
ENSMUST00000056484
resolver
enst
ENSMUST00000108634
resolver
genesymbol
Nlgn2
resolver
genesymbol_syn
Kiaa1366
resolver
uniprot
Q5F288
resolver
uniprot
Q6PHN2
resolver
uniprot_entry
NLGN2_MOUSE
resolver
uniprot_entry
Q6PHN2_MOUSE
resolver
uniprot_sec
Q5F288
resolver
amino_acid_sequence
MWLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVVTLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSTEAVECLRRKSSRELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRTPGPGTSGTRRPPPPATLPPESDIDLGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPTAGRELPPEEELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV
uniprot
proteins
function
FUNCTION: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (PubMed:29742426). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. {ECO:0000250, ECO:0000269|PubMed:10892652, ECO:0000269|PubMed:15620359, ECO:0000269|PubMed:16982420, ECO:0000269|PubMed:19553444, ECO:0000269|PubMed:19889999, ECO:0000269|PubMed:20530218, ECO:0000269|PubMed:29742426, ECO:0000269|PubMed:30100184}.
uniprot
proteins
mass_dalton
90989
uniprot
proteins
mutagenesis
MUTAGEN 586..590; /note="KPRVR->APAVA: Reduced presynaptic differentiation."; /evidence="ECO:0000269|PubMed:30100184
uniprot
proteins
post_translational_modification
PTM: N-glycosylated, contains high-mannose, hybrid, complex and sialylated N-glycans (PubMed:37865312). N-glycosylation is essential for localization to synapses, dendrites, and the cell membrane, and enhances its availability for trans-synaptic adhesion. O-glycosylated (By similarity). {ECO:0000250|UniProtKB:Q62888, ECO:0000269|PubMed:37865312}.
uniprot
proteins
protein_family
Type-B carboxylesterase/lipase family
uniprot
proteins
pubmed
10892652
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15620359
uniprot
proteins
pubmed
16982420
uniprot
proteins
pubmed
17897391
uniprot
proteins
pubmed
18250328
uniprot
proteins
pubmed
18434543
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19553444
uniprot
proteins
pubmed
19755106
uniprot
proteins
pubmed
19859968
uniprot
proteins
pubmed
19889999
uniprot
proteins
pubmed
19926856
uniprot
proteins
pubmed
20530218
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23358245
uniprot
proteins
pubmed
23751499
uniprot
proteins
pubmed
28279354
uniprot
proteins
pubmed
29742426
uniprot
proteins
pubmed
30100184
uniprot
proteins
pubmed
37865312
uniprot
proteins
sequence_length
836
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37865312}; Single-pass type I membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000269|PubMed:29742426}; Single-pass type I membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000269|PubMed:19859968}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q62888}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q62888}. Synapse {ECO:0000250|UniProtKB:Q62888}. Note=Detected at postsynaptic membranes in brain. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina. Localizes to dendritic membrane. {ECO:0000250|UniProtKB:Q62888, ECO:0000269|PubMed:19859968, ECO:0000269|PubMed:29742426}.
uniprot
proteins
transmembrane_region
TRANSMEM 679..699; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins