RHBDL1
entrez
9028
canonical
uniprot
O75783
canonical
ensembl
ENSG00000103269
resolver
ensp
ENSP00000219551
resolver
ensp
ENSP00000344206
resolver
ensp
ENSP00000673461
resolver
genesymbol
RHBDL1
resolver
genesymbol_syn
RHBDL
resolver
hgnc
HGNC:10007
resolver
uniprot
A2IDC0
resolver
uniprot
A2IDC1
resolver
uniprot
Q0VAX4
resolver
uniprot
Q9NQ85
resolver
uniprot_entry
RHBL1_HUMAN
resolver
uniprot_sec
A2IDC0
resolver
uniprot_sec
A2IDC1
resolver
uniprot_sec
Q0VAX4
resolver
uniprot_sec
Q9NQ85
resolver
amino_acid_sequence
MGRVEDGGTTEELEDWDPGTSALPAPGIKQGPREQTGTGPLSQKCWEPEPDAPSQPGPALWSRGRARTQALAGGSSLQQLDPENTGFIGADTFTGLVHSHELPLDPAKLDMLVALAQSNEQGQVCYQELVDLISSKRSSSFKRAIANGQRALPRDGPLDEPGLGVYKRFVRYVAYEILPCEVDRRWYFYRHRSCPPPVFMASVTLAQIIVFLCYGARLNKWVLQTYHPEYMKSPLVYHPGHRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYLAGVLAGSLTVSITDMRAPVVGGSGGVYALCSAHLANVVMNWAGMRCPYKLLRMVLALVCMSSEVGRAVWLRFSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCGWWVVLLAYGTFLLFAVFWNVFAYDLLGAHIPPPP
uniprot
proteins
ec_number
3.4.21.105
uniprot
proteins
function
FUNCTION: Regulator of proteosome activity independent of enzymatic activity (PubMed:26109405). May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. {ECO:0000250, ECO:0000269|PubMed:26109405}.
uniprot
proteins
mass_dalton
48314
uniprot
proteins
mutagenesis
MUTAGEN 312; /note="S->A: Protease dead but no change in regulation of proteosome activity."; /evidence="ECO:0000269|PubMed:26109405
uniprot
proteins
protein_family
Peptidase S54 family
uniprot
proteins
pubmed
11157797
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
26109405
uniprot
proteins
pubmed
9662444
uniprot
proteins
sequence_length
438
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 262..282; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 284..304; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 308..328; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 340..359; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 372..392; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 405..425; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins