MTA1
entrez
9112
canonical
uniprot
Q13330
canonical
ensembl
ENSG00000182979
resolver
ensp
ENSP00000333633
resolver
ensp
ENSP00000384180
resolver
ensp
ENSP00000385702
resolver
ensp
ENSP00000393438
resolver
ensp
ENSP00000609589
resolver
enst
ENST00000406191
resolver
genesymbol
MTA1
resolver
hgnc
HGNC:7410
resolver
uniprot
A5PLK4
resolver
uniprot
E7ESY4
resolver
uniprot
Q86SW2
resolver
uniprot
Q8NFI8
resolver
uniprot
Q96GI8
resolver
uniprot
Q9BRL8
resolver
uniprot_entry
E7ESY4_HUMAN
resolver
uniprot_entry
MTA1_HUMAN
resolver
uniprot_entry
Q9BRL8_HUMAN
resolver
uniprot_sec
A5PLK4
resolver
uniprot_sec
Q86SW2
resolver
uniprot_sec
Q8NFI8
resolver
uniprot_sec
Q96GI8
resolver
amino_acid_sequence
MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSTLIALADKHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKLKHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTTQSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSGSPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEASQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTILGKRSYEQHNGVDGNMKKRLLMPSRGLANHGQARHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWIDAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPPRPPPPAPVNDEPIVIED
uniprot
proteins
disease_involvement
DISEASE: Note=Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, IFI16 and HDAC4/5/6-dependent manner. {ECO:0000269|PubMed:24413532}.
uniprot
proteins
function
FUNCTION: Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}.
uniprot
proteins
mass_dalton
80786
uniprot
proteins
mutagenesis
MUTAGEN 182; /note="K->A: Reduced ubiquitination. Significant reduction in ubiquitination; when associated with A-626."; /evidence="ECO:0000269|PubMed:19805145"; MUTAGEN 509; /note="K->R: Reduced sumoylation and transcriptional corepressor activity."; /evidence="ECO:0000269|PubMed:21965678"; MUTAGEN 626; /note="K->A: Loss of acetylation and transcriptional coactivator activity. Reduced ubiquitination. Significant reduction in ubiquitination; when associated with A-182."; /evidence="ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:19805145"; MUTAGEN 711..713; /note="IVI->AAA: Significant loss of interaction with SUMO1 and SUMO2 and reduced transcriptional corepressor activity."; /evidence="ECO:0000269|PubMed:21965678
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by CSNK1G2/CK1 triggered by estrogen enhances corepression of estrogen receptor (ER). {ECO:0000269|PubMed:15077195}.; PTM: Acetylation is essential for its transcriptional coactivator activity. {ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:19805145}.; PTM: Sumoylation positively regulates its transcriptional corepressor activity but does not affect the protein stability. Sumoylated preferentially by SUMO2 or SUMO3 than SUMO1. Sumoylation is enhanced by PIAS1/3/4 and preferentially sumoylated by SUMO2 in the presence of PIAS1/3/4. Desumoylated by SENP1. {ECO:0000269|PubMed:21965678}.; PTM: Ubiquitinated by COP1, which leads to proteasomal degradation. {ECO:0000269|PubMed:19805145}.
uniprot
proteins
protein_family
Metastasis-associated protein family
uniprot
proteins
pubmed
12167865
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15077195
uniprot
proteins
pubmed
15254226
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15701600
uniprot
proteins
pubmed
16428440
uniprot
proteins
pubmed
16617102
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17671180
uniprot
proteins
pubmed
17922032
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19805145
uniprot
proteins
pubmed
19837670
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20682799
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21965678
uniprot
proteins
pubmed
22253283
uniprot
proteins
pubmed
22926524
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24413532
uniprot
proteins
pubmed
24920672
uniprot
proteins
pubmed
24970816
uniprot
proteins
pubmed
25948590
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28977666
uniprot
proteins
pubmed
30327463
uniprot
proteins
pubmed
33283408
uniprot
proteins
pubmed
7607577
uniprot
proteins
pubmed
8083195
uniprot
proteins
pubmed
9885572
uniprot
proteins
sequence_length
715
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}.; SUBCELLULAR LOCATION: [Isoform Short]: Cytoplasm {ECO:0000269|PubMed:12167865, ECO:0000269|PubMed:15077195}.; SUBCELLULAR LOCATION: [Isoform Long]: Nucleus {ECO:0000269|PubMed:21965678}. Nucleus envelope {ECO:0000269|PubMed:24970816}. Cytoplasm {ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:24970816}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24970816}. Note=Associated with microtubules (PubMed:24970816). Localization at the nuclear envelope is TPR-dependent (PubMed:24970816). {ECO:0000269|PubMed:24970816}.
uniprot
proteins