HCN3
entrez
57657
canonical
uniprot
Q9P1Z3
canonical
ensembl
ENSG00000143630
resolver
ensembl
ENSG00000263324
resolver
ensp
ENSP00000357342
resolver
ensp
ENSP00000458364
resolver
ensp
ENSP00000548045
resolver
enst
ENST00000368358
resolver
enst
ENST00000575670
resolver
genesymbol
HCN3
resolver
genesymbol_syn
KIAA1535
resolver
hgnc
HGNC:19183
resolver
uniprot
D3DV90
resolver
uniprot
Q4VX12
resolver
uniprot
Q8N6W6
resolver
uniprot
Q9BWQ2
resolver
uniprot_entry
HCN3_HUMAN
resolver
uniprot_sec
D3DV90
resolver
uniprot_sec
Q4VX12
resolver
uniprot_sec
Q8N6W6
resolver
uniprot_sec
Q9BWQ2
resolver
activity_regulation
ACTIVITY REGULATION: Unlike HCN2 and HCN4, HCN3 is insensitive to cyclic nucleotides, such as cAMP or cGMP. This lack of sensitivity of HCN3, despite harboring a functional cyclic nucleotide-binding domain (CNBD), may be explained by its shorter C-terminal sequence, which may alter the normal autoinhibition of the channel (PubMed:16043489). Inhibited by Cs(1+) and ZD7288 (PubMed:16043489). Phosphatidylinositol-4,5-bisphosphate (PIP(2)) shifts HCN3 activation to more depolarized potentials and accelerated activation kinetics (By similarity). {ECO:0000250|UniProtKB:O88705, ECO:0000269|PubMed:16043489}.
uniprot
proteins
amino_acid_sequence
MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM
uniprot
proteins
function
FUNCTION: Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions, with an about 3:1 preference for potassium ions (PubMed:16043489). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). In particular, plays a pivotal role in maintaining excitability and promoting rhythmic burst firing within hypothalamic nuclei. Exerts a significant influence on the configuration of the cardiac action potential waveform. Does not appear to play a prominent role in the processing of acute, neuropathic, or inflammatory pain (By similarity). {ECO:0000250|UniProtKB:O88705, ECO:0000269|PubMed:16043489}.
uniprot
proteins
mass_dalton
86032
uniprot
proteins
protein_family
Potassium channel HCN family
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16043489
uniprot
proteins
pubmed
16710414
uniprot
proteins
sequence_length
774
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16043489}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 98..118; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 125..145; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 172..192; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 202..222; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 254..274; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 330..350; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:O60741
uniprot
proteins