Myl9
entrez
98932
canonical
uniprot
Q9CQ19
canonical
ensembl
ENSMUSG00000067818
resolver
ensp
ENSMUSP00000085913
resolver
ensp
ENSMUSP00000281689
resolver
enst
ENSMUST00000088552
resolver
genesymbol
Myl9
resolver
genesymbol_syn
Myrl2
resolver
uniprot
Q3TW15
resolver
uniprot
Q80X77
resolver
uniprot_entry
MYL9_MOUSE
resolver
uniprot_sec
Q3TW15
resolver
uniprot_sec
Q80X77
resolver
amino_acid_sequence
MSSKRAKAKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDEYLEGMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEASGFIHEDHLRELLTTMGDRFTDEEVDEMYREAPIDKKGNFNYVEFTRILKHGAKDKDD
uniprot
proteins
function
FUNCTION: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation (PubMed:41791372). Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). In myoblasts, regulates PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (PubMed:29799007). {ECO:0000250|UniProtKB:P24844, ECO:0000269|PubMed:29799007, ECO:0000269|PubMed:41791372}.
uniprot
proteins
mass_dalton
19854
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="T->D: Prevents aberrant myotube formation in PIEZO1-deficient myoblast; when associated with D-20."; /evidence="ECO:0000269|PubMed:29799007"; MUTAGEN 20; /note="S->D: Prevents aberrant myotube formation in PIEZO1-deficient myoblast; when associated with D-19."; /evidence="ECO:0000269|PubMed:29799007
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by MLCK/MYLK increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity (PubMed:41791372). It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge (PubMed:41791372). Phosphorylation is required for myotube formation (PubMed:29799007). Phosphorylated by DAPK3; DAPK3-mediated phosphorylation is inhibited by LUZP1 (By similarity). {ECO:0000250|UniProtKB:P24844, ECO:0000269|PubMed:29799007, ECO:0000269|PubMed:41791372}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17015463
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24825904
uniprot
proteins
pubmed
29799007
uniprot
proteins
pubmed
41791372
uniprot
proteins
sequence_length
172
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:29799007}. Cytoplasm, cell cortex {ECO:0000269|PubMed:29799007}. Note=Colocalizes with F-actin, MYH9 and PIEZO1 at the actomyosin cortex in myoblasts. {ECO:0000269|PubMed:29799007}.
uniprot
proteins