MAGEA6
entrez
4105
canonical
uniprot
P43360
canonical
ensembl
ENSG00000197172
resolver
ensembl
ENSG00000292195
resolver
ensp
ENSP00000329199
resolver
ensp
ENSP00000480637
resolver
ensp
ENSP00000517987
resolver
ensp
ENSP00000517988
resolver
ensp
ENSP00000593324
resolver
enst
ENST00000329342
resolver
enst
ENST00000616035
resolver
enst
ENST00000710006
resolver
enst
ENST00000710007
resolver
enst
ENST00000923265
resolver
genesymbol
MAGEA6
resolver
genesymbol_syn
MAGE6
resolver
hgnc
HGNC:6804
resolver
uniprot
A8IF93
resolver
uniprot
Q6NW44
resolver
uniprot_entry
MAGA6_HUMAN
resolver
uniprot_sec
A8IF93
resolver
uniprot_sec
Q6NW44
resolver
amino_acid_sequence
MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAKLVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASDSLQLVFGIELMEVDPIGHVYIFATCLGLSYDGLLGDNQIMPKTGFLIIILAIIAKEGDCAPEEKIWEELSVLEVFEGREDSIFGDPKKLLTQYFVQENYLEYRQVPGSDPACYEFLWGPRALIETSYVKVLHHMVKISGGPRISYPLLHEWALREGEE
uniprot
proteins
function
FUNCTION: Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy (PubMed:17942928, PubMed:20864041, PubMed:31267705). May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:17942928, PubMed:20864041). May play a role in tumor transformation or aspects of tumor progression (PubMed:17942928, PubMed:20864041). In vitro promotes cell viability in melanoma cell lines (PubMed:17942928). {ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:31267705}.
uniprot
proteins
mass_dalton
34891
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the DCX(DCAF12) complex specifically recognizes the diglutamate (Glu-Glu) at the C-terminus, leading to its degradation. {ECO:0000269|PubMed:31267705}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17942928
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20598277
uniprot
proteins
pubmed
20864041
uniprot
proteins
pubmed
31267705
uniprot
proteins
pubmed
7642112
uniprot
proteins
pubmed
7927540
uniprot
proteins
pubmed
8037761
uniprot
proteins
sequence_length
314
uniprot
proteins