Nedd4
entrez
17999
canonical
uniprot
P46935
canonical
ensembl
ENSMUSG00000032216
resolver
ensp
ENSMUSP00000034740
resolver
ensp
ENSMUSP00000158796
resolver
ensp
ENSMUSP00000212719
resolver
enst
ENSMUST00000034740
resolver
genesymbol
Nedd4
resolver
genesymbol_syn
Kiaa0093
resolver
genesymbol_syn
Nedd-4
resolver
genesymbol_syn
Nedd4-1
resolver
genesymbol_syn
Nedd4a
resolver
genesymbol_syn
Rpf1
resolver
uniprot
B2RSC8
resolver
uniprot
O08758
resolver
uniprot
Q3UZI2
resolver
uniprot
Q8BGB3
resolver
uniprot_entry
B2RSC8_MOUSE
resolver
uniprot_entry
NEDD4_MOUSE
resolver
uniprot_sec
O08758
resolver
uniprot_sec
Q3UZI2
resolver
uniprot_sec
Q8BGB3
resolver
activity_regulation
ACTIVITY REGULATION: Activated by NDFIP1- and NDFIP2-binding. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MSSDMAADESEAPVLSEDEVWEFCLDKTEDGGGSPGSDVTDTCEPPCGCWELNPNSLEEEHVLFTADPYLELHNDDTRVVRVKVIAGIGLAKKDILGASDPYVRVTLYDPMSGILTSVQTKTIKKSLNPKWNEEILFRVLPQRHRILFEVFDENRLTRDDFLGQVDVPLYPLPTENPRMERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKNGSEDENADQAEELEPGWVVLDQPDAATHLPHPPEPSPLPPGWEERQDVLGRTYYVNHESRRTQWKRPSPDDDLTDEDNDDMQLQAQRAFTTRRQISEDVDGPDNRESPENWEIVREDENTEYSGQAVQSPPSGHIDVQTHLAEEFNTRLAVCGNPATSQPVTSSNHSSRGGSLQTCIFEEQPTLPVLLPTSSGLPPGWEEKQDDRGRSYYVDHNSKTTTWSKPTMQDDPRSKIPAHLRGKTDSNDLGPLPPGWEERTHTDGRVFFINHNIKKTQWEDPRLQNVAITGPAVPYSRDYKRKYEFFRRKLKKQTDIPNKFEMKLRRANILEDSYRRIMGVKRADLLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEYYSSLRWILENDPTELDLRFIIDEELFGQTHQHELKTGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSMNHQVIHWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPDKLPRAHTCFNRLDLPPYESFDELWDKLQMAIENTQGFDGVD
uniprot
proteins
ec_number
2.3.2.26
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes (PubMed:18286479). Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19193720). Predominantly involved in ubiquitination of membrane bound forms of ERBB4 rather than processed precursors and intermediate membrane-anchored 80 kDa fragments (m80HER4), with a lesser role in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19047365). Promotes ubiquitination of RAPGEF2. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (PubMed:20159449). Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (By similarity). Ubiquitinates DAZAP2, leading to its proteasomal degradation (By similarity). Ubiquitinates POLR2A (By similarity). Functions as a platform to recruit USP13 to form an NEDD4-USP13 deubiquitination complex that plays a critical role in cleaving the 'Lys-48'-linked ubiquitin chains of VPS34 and then stabilizing VPS34, thus promoting the formation of autophagosomes (By similarity). {ECO:0000250|UniProtKB:P46934, ECO:0000269|PubMed:18286479, ECO:0000269|PubMed:19047365, ECO:0000269|PubMed:19193720}.
uniprot
proteins
mass_dalton
102706
uniprot
proteins
mutagenesis
MUTAGEN 854; /note="C->S: Loss of ubiquitin-ligase activity. No effect on VEGFR-2/KDFR degradation."; /evidence="ECO:0000269|PubMed:15060076
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Undergoes 'Lys-29'-linked auto-ubiquitination at Lys-847 and serves as a scaffold for recruiting USP13 to form an NEDD4-USP13 deubiquitination complex. {ECO:0000250|UniProtKB:P46934}.
uniprot
proteins
pubmed
11042109
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
12697834
uniprot
proteins
pubmed
1378265
uniprot
proteins
pubmed
15060076
uniprot
proteins
pubmed
15908698
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18286479
uniprot
proteins
pubmed
19047365
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19193720
uniprot
proteins
pubmed
20159449
uniprot
proteins
pubmed
20980250
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28784777
uniprot
proteins
pubmed
9182527
uniprot
proteins
pubmed
9407065
uniprot
proteins
sequence_length
887
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9182527}. Nucleus {ECO:0000250|UniProtKB:P46934}. Cell membrane {ECO:0000269|PubMed:18286479}; Peripheral membrane protein {ECO:0000269|PubMed:18286479}. Note=Predominantly cytoplasmic but also located in the nucleus (By similarity). Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (PubMed:18286479). May be recruited to exosomes by NDFIP1 (By similarity). {ECO:0000250|UniProtKB:P46934, ECO:0000269|PubMed:18286479}.
uniprot
proteins