Rab4b
entrez
19342
canonical
uniprot
Q91ZR1
canonical
ensembl
ENSMUSG00000053291
resolver
ensp
ENSMUSP00000090727
resolver
enst
ENSMUST00000093040
resolver
genesymbol
Rab4b
resolver
genesymbol_syn
Rab4
resolver
genesymbol_syn
Rab4B
resolver
uniprot
Q4V9W8
resolver
uniprot_entry
Q4V9W8_MOUSE
resolver
uniprot_entry
RAB4B_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILCGNKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDPERMGSGIQYGDISLRQLRQPRSAQAVAPQPCGC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:14697203). RAB4B mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB14 (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (PubMed:14697203). {ECO:0000250|UniProtKB:P61018, ECO:0000269|PubMed:14697203}.
uniprot
proteins
mass_dalton
23629
uniprot
proteins
post_translational_modification
PTM: Serotonylation of Gln-67 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity. {ECO:0000269|PubMed:14697203}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
14697203
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
213
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P61018}; Lipid-anchor {ECO:0000250|UniProtKB:P61018}; Cytoplasmic side {ECO:0000250|UniProtKB:P61018}. Early endosome membrane {ECO:0000250|UniProtKB:P61018}; Lipid-anchor {ECO:0000250|UniProtKB:P61018}; Cytoplasmic side {ECO:0000250|UniProtKB:P61018}.
uniprot
proteins