Eif4enif1
entrez
74203
canonical
uniprot
Q9EST3
canonical
ensembl
ENSMUSG00000020454
resolver
ensp
ENSMUSP00000020734
resolver
ensp
ENSMUSP00000105675
resolver
ensp
ENSMUSP00000105676
resolver
ensp
ENSMUSP00000136768
resolver
ensp
ENSMUSP00000172767
resolver
ensp
ENSMUSP00000172769
resolver
ensp
ENSMUSP00000172771
resolver
genesymbol
Eif4enif1
resolver
genesymbol_syn
Clast4
resolver
uniprot
Q8BY82
resolver
uniprot
Q8CFW0
resolver
uniprot
Q9CSS3
resolver
uniprot_entry
4ET_MOUSE
resolver
uniprot_entry
Q8BY82_MOUSE
resolver
uniprot_sec
Q8CFW0
resolver
uniprot_sec
Q9CSS3
resolver
amino_acid_sequence
MEKSVAETENGDAFLELKKLPTSKSPHRYTKEELLDIKERPYSKQRPSCLSEKYDSDGVWDPEKWHASLYPASGRSSPVESLKKESESDRPSLVRRIADPRERVKEDDLDVVLSPQRRSFGGGCHVTAAVSSRRSGSPLEKDSDGLRLLGGRRIGSGRIISARAFEKDHRLSDKDLRDLRDRDRERDYKDKRFRREFGDSKRVFGERRRNDSYTEEEPEWFSAGPTSQSETIELTGFDDKILEEDHKGRKRTRRRTASVKEGIVECNGGVAEEDEVEVILAQEPSADQEVPRDVILPEQSPGEFDFNEFFNLDKVPCLASMIEDVLGEGSVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAVLSPGQNSGNYFAPIPSEDHAENKVDILEMLQKAKVDLKPLLSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQMKNSTPFMAEHLEETLSAASSNRQLKKDGDMTAFNKLVNTMKASGTLPTQPKVSRNVESHLLAPAEIPGQPVSKNILQELLGQPVQRPASSNLLSGLMGSLEATASLLSQRAPSPPMSQVFRTQAASADYLHPRIPSPIGFPSGPQQLLGDPFQGMRKPMSPVSAQMSQLELQQAALEGLALPHDLAVQTAPFYQPGFSKPQVDRTRDGLRNRQQRMSKSPAPMHGGNSSSPAPAASITSMLSPSFTPTSVIRKMYESREKTKEEMAPGMVVPGDGKEDTQKTSEENLLSSNPIPNTDQDSSTTNPKLSTLQRSSCSTPLSQTSRYTKEQDYRPKTAGRKTPTLASPVPGTPFLRPTHQVPLVPHVPIVRPAHQLHPGLVQRLIAQGVHPQHLPSLLQAGVLPPGIDMAPLQGLSGPLLGQPLYPLVSAASHPLLNPRPGTPLHLAVMQQQLQRSVLHPPGSSSQAAAISVQTPQNVPSRSGMPHMHSQLEHRTSQRSSSPVGLAKWFGSDVLQQPLPSMPTKVISVDELEYRQ
uniprot
proteins
function
FUNCTION: EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:25456498). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (By similarity). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (PubMed:25456498). Promotes miRNA-mediated translational repression (By similarity). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (By similarity). Required for the formation of P-bodies (By similarity). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (By similarity). {ECO:0000250|UniProtKB:Q9NRA8, ECO:0000269|PubMed:25456498}.
uniprot
proteins
mass_dalton
107986
uniprot
proteins
mutagenesis
MUTAGEN 29..34; /note="YTKEEL->ATKEEA: Abolished interaction with EIF4E."; /evidence="ECO:0000269|PubMed:16343815
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by MAPK8/JNK1 and or MAPK9/JNK2 in response to oxidative stress promotes P-body assembly (By similarity). Phosphorylated during meiotic maturation (PubMed:16343815). {ECO:0000250|UniProtKB:Q9NRA8, ECO:0000269|PubMed:16343815}.
uniprot
proteins
protein_family
4E-T/EIF4E-T family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16343815
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25456498
uniprot
proteins
sequence_length
983
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16343815}. Nucleus {ECO:0000250|UniProtKB:Q9NRA8}. Nucleus, PML body {ECO:0000250|UniProtKB:Q9NRA8}. Nucleus speckle {ECO:0000250|UniProtKB:Q9NRA8}. Note=Predominantly cytoplasmic (By similarity). Mainly localizes to processing bodies (P-bodies) (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription (By similarity). {ECO:0000250|UniProtKB:Q9NRA8}.
uniprot
proteins