TBC1D10B
entrez
26000
canonical
uniprot
Q4KMP7
canonical
ensembl
ENSG00000169221
resolver
ensp
ENSP00000386538
resolver
ensp
ENSP00000606872
resolver
genesymbol
TBC1D10B
resolver
hgnc
HGNC:24510
resolver
uniprot
B9A6L0
resolver
uniprot
Q6IN54
resolver
uniprot
Q6P530
resolver
uniprot
Q71RG7
resolver
uniprot
Q86VC5
resolver
uniprot
Q9H8Z2
resolver
uniprot
Q9NUN6
resolver
uniprot
Q9UFP2
resolver
uniprot_entry
TB10B_HUMAN
resolver
uniprot_sec
B9A6L0
resolver
uniprot_sec
Q6IN54
resolver
uniprot_sec
Q6P530
resolver
uniprot_sec
Q71RG7
resolver
uniprot_sec
Q86VC5
resolver
uniprot_sec
Q9H8Z2
resolver
uniprot_sec
Q9NUN6
resolver
uniprot_sec
Q9UFP2
resolver
amino_acid_sequence
METGTAPLVAPPRRHGAPAAPSPPPRGSRAGPVVVVAPGPPVTTATSAPVTLVAPGEARPAWVPGSAETSAPAPAPAPAPAPAVTGSTVVVLTLEASPEAPKPQLPSGPESPEPAAVAGVETSRALAAGADSPKTEEARPSPAPGPGTPTGTPTRTPSRTAPGALTAKPPLAPKPGTTVASGVTARSASGQVTGGHGAAAATSASAGQAPEDPSGPGTGPSGTCEAPVAVVTVTPAPEPAENSQDLGSTSSLGPGISGPRGQAPDTLSYLDSVSLMSGTLESLADDVSSMGSDSEINGLALRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRGELQYRPSRRLHGSRAIHEERRRQQPPLGPSSSLLSLPGLKSRGSRAAGGAPSPPPPVRRASAGPAPGPVVTAEGLHPSLPSPTGNSTPLGSSKETRKQEKERQKQEKERQKQEKEREKERQKQEKEREKQEKEREKQEKERQKQEKKAQGRKLSLRRKADGPPGPHDGGDRPSAEARQDAYF
uniprot
proteins
function
FUNCTION: Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}.
uniprot
proteins
mass_dalton
87199
uniprot
proteins
mutagenesis
MUTAGEN 409; /note="R->L: Loss of GAP activity. Unable to exclude RAB3A from the dense-core vesicles, when tested in a pheochromocytoma cell line."; /evidence="ECO:0000269|PubMed:19077034
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16923811
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19077034
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
808
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16923811}. Cell membrane {ECO:0000269|PubMed:19077034}. Note=Predominantly localizes near the plasma membrane (PubMed:16923811). In melanocytes, located at the periphery of cells (PubMed:16923811). {ECO:0000269|PubMed:16923811}.
uniprot
proteins