Mesd
entrez
67943
canonical
uniprot
Q9ERE7
canonical
ensembl
ENSMUSG00000038503
resolver
ensp
ENSMUSP00000091768
resolver
enst
ENSMUST00000094215
resolver
genesymbol
Mesd
resolver
genesymbol_syn
Mesdc2
resolver
uniprot
Q8C611
resolver
uniprot
Q8CCX7
resolver
uniprot
Q91WK8
resolver
uniprot
Q9CVB9
resolver
uniprot_entry
MESD_MOUSE
resolver
uniprot_sec
Q8C611
resolver
uniprot_sec
Q8CCX7
resolver
uniprot_sec
Q91WK8
resolver
uniprot_sec
Q9CVB9
resolver
amino_acid_sequence
MAASRWLRAVLLFLCASDLLLLPPPNAYAADTPGEATPPPRKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPIDFSKLDPGKPESILKMTKKGKTLMMFVTVSGNPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVSQDRCAEVTLEGQMYPGKGGGSKEKNKTKPEKAKKKEGDPKPRASKEDNRAGSRREDL
uniprot
proteins
function
FUNCTION: Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs) (PubMed:31564437). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction (PubMed:12581525, PubMed:21397183, PubMed:21375506). Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (PubMed:24140340). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells. {ECO:0000269|PubMed:12581525, ECO:0000269|PubMed:21375506, ECO:0000269|PubMed:21397183, ECO:0000269|PubMed:24140340, ECO:0000269|PubMed:27184668, ECO:0000269|PubMed:31564437}.
uniprot
proteins
mass_dalton
25207
uniprot
proteins
protein_family
MESD family
uniprot
proteins
pubmed
11247670
uniprot
proteins
pubmed
12581525
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17342452
uniprot
proteins
pubmed
20506034
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21375506
uniprot
proteins
pubmed
21397183
uniprot
proteins
pubmed
21397184
uniprot
proteins
pubmed
21397185
uniprot
proteins
pubmed
24140340
uniprot
proteins
pubmed
27184668
uniprot
proteins
pubmed
31564437
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:12581525}. Note=Released from apoptotic cells and shed photoreceptor outer segments (PubMed:27184668). {ECO:0000269|PubMed:27184668}.
uniprot
proteins