P45446
uniprot
P45446
canonical
amino_acid_sequence
MCENQLKTKADGTAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNTETGGTYANGHVIDLPKSEGYYNIDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVHNLFTYSSFNNGQLAPGITMSEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLLEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPDIVNTLFPPLYKELFNPDCAAVCK
uniprot
proteins
function
FUNCTION: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity. {ECO:0000269|PubMed:12958591, ECO:0000269|PubMed:8816759}.; FUNCTION: [Isoform 1]: Critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity). {ECO:0000250|UniProtKB:Q8R1B8}.
uniprot
proteins
mass_dalton
53201
uniprot
proteins
mutagenesis
MUTAGEN 280; /note="A->F,V,S: Inhibits transactivation activity."; /evidence="ECO:0000269|PubMed:11689423"; MUTAGEN 280; /note="A->G: No effect on transactivation activity."; /evidence="ECO:0000269|PubMed:11689423"; MUTAGEN 457; /note="Y->A: Inhibits transactivation activity."; /evidence="ECO:0000269|PubMed:11689423"; MUTAGEN 459; /note="E->A: Inhibits transactivation activity."; /evidence="ECO:0000269|PubMed:11689423
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
11689423
uniprot
proteins
pubmed
12958591
uniprot
proteins
pubmed
7935491
uniprot
proteins
pubmed
8816759
uniprot
proteins
pubmed
9670004
uniprot
proteins
pubmed
9729429
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q92753}.
uniprot
proteins