OAS3
entrez
4940
canonical
uniprot
Q9Y6K5
canonical
ensembl
ENSG00000111331
resolver
ensp
ENSP00000228928
resolver
ensp
ENSP00000505225
resolver
enst
ENST00000228928
resolver
enst
ENST00000681497
resolver
genesymbol
OAS3
resolver
hgnc
HGNC:8088
resolver
uniprot
A0A7P0T8S7
resolver
uniprot
Q2HJ14
resolver
uniprot
Q9H3P5
resolver
uniprot_entry
A0A7P0T8S7_HUMAN
resolver
uniprot_entry
OAS3_HUMAN
resolver
uniprot_sec
Q2HJ14
resolver
uniprot_sec
Q9H3P5
resolver
activity_regulation
ACTIVITY REGULATION: Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection (Probable). Strongly activated by long dsRNAs at least 50 nucleotides in length (PubMed:25775560). ssRNA does not activate the enzyme (PubMed:25775560). {ECO:0000269|PubMed:25775560, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MDLYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKGGSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVPGLRLTFPEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNSGCQGGEHAACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIFAWEQGCKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPVILDPADPTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSWKGPGLPRAGCSGLGHPIQLDPNQKTPENSKSLNAVYPRAGSKPPSCPAPGPTGAASIVPSVPGMALDLSQIPTKELDRFIQDHLKPSPQFQEQVKKAIDIILRCLHENCVHKASRVSKGGSFGRGTDLRDGCDVELIIFLNCFTDYKDQGPRRAEILDEMRAQLESWWQDQVPSLSLQFPEQNVPEALQFQLVSTALKSWTDVSLLPAFDAVGQLSSGTKPNPQVYSRLLTSGCQEGEHKACFAELRRNFMNIRPVKLKNLILLVKHWYRQVAAQNKGKGPAPASLPPAYALELLTIFAWEQGCRQDCFNMAQGFRTVLGLVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKPRPLVLDPADPTWNVGHGSWELLAQEAAALGMQACFLSRDGTSVQPWDVMPALLYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTICSFLKENCFRNSPIKVIKVVKGGSSAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEIISEIRAQLEACQQERQFEVKFEVSKWENPRVLSFSLTSQTMLDQSVDFDVLPAFDALGQLVSGSRPSSQVYVDLIHSYSNAGEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKISKGRGSLPPQHGLELLTVYAWEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKDKTVGDFLKQQLQKPRPIILDPADPTGNLGHNARWDLLAKEAAACTSALCCMGRNGIPIQPWPVKAAV
uniprot
proteins
ec_number
2.7.7.84
uniprot
proteins
function
FUNCTION: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Catalyzes preferentially the dimerization of ATP to form 2'-5'-diadenylate (2-5A), but can also form the trimeric 2'-5'-oligoadenylate. The oligoadenylate then binds to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). {ECO:0000269|PubMed:19056102, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880533}.
uniprot
proteins
mass_dalton
121170
uniprot
proteins
mutagenesis
MUTAGEN 30; /note="R->A: Impaired dsRNA binding."; /evidence="ECO:0000269|PubMed:25775560"; MUTAGEN 41; /note="R->A: Impaired dsRNA binding."; /evidence="ECO:0000269|PubMed:25775560"; MUTAGEN 76; /note="E->D: No effect on catalytic activity; when associated with D-145."; /evidence="ECO:0000269|PubMed:25775560"; MUTAGEN 145; /note="S->D: No effect on catalytic activity. No effect on catalytic activity; when associated with D-76."; /evidence="ECO:0000269|PubMed:25775560"; MUTAGEN 816..818; /note="DAD->AAA: Abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:25775560
uniprot
proteins
protein_family
2-5A synthase family
uniprot
proteins
pubmed
11112351
uniprot
proteins
pubmed
11280764
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17408844
uniprot
proteins
pubmed
19056102
uniprot
proteins
pubmed
19904482
uniprot
proteins
pubmed
19923450
uniprot
proteins
pubmed
21142819
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25775560
uniprot
proteins
pubmed
36538032
uniprot
proteins
pubmed
9880533
uniprot
proteins
sequence_length
1087
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
uniprot
proteins