Ccnd2
entrez
12444
canonical
uniprot
P30280
canonical
ensembl
ENSMUSG00000000184
resolver
ensp
ENSMUSP00000000188
resolver
enst
ENSMUST00000000188
resolver
genesymbol
Ccnd2
resolver
genesymbol_syn
Cyl-2
resolver
uniprot
Q4FK45
resolver
uniprot_entry
CCND2_MOUSE
resolver
uniprot_entry
Q4FK45_MOUSE
resolver
amino_acid_sequence
MELLCCEVDPVRRAVPDRNLLEDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKTHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSVKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQKEKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDDEVNTLTCDALTELLAKITHTDVDCLKACQEQIEALLLNSLQQFRQEQHNAGSKSVEDPDQATTPTDVRDVDL
uniprot
proteins
function
FUNCTION: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. {ECO:0000250|UniProtKB:P30279}.
uniprot
proteins
mass_dalton
32897
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-280 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex. {ECO:0000250|UniProtKB:P24385}.; PTM: Ubiquitinated by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation: ubiquitination is dependent on Thr-280 phosphorylation (PubMed:33854232, PubMed:33854235). The DCX(AMBRA1) complex represents the major regulator of CCND2 stability during the G1/S transition (PubMed:33854232, PubMed:33854235). Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:P30279, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854235}.
uniprot
proteins
protein_family
Cyclin D subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
1372445
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1827757
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33854232
uniprot
proteins
pubmed
33854235
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P30279}. Cytoplasm {ECO:0000250|UniProtKB:P30279}. Nucleus membrane {ECO:0000250|UniProtKB:P30279}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250|UniProtKB:P30279}.
uniprot
proteins