Marchf1
entrez
72925
canonical
uniprot
Q6NZQ8
canonical
ensembl
ENSMUSG00000036469
resolver
ensp
ENSMUSP00000044070
resolver
ensp
ENSMUSP00000072302
resolver
ensp
ENSMUSP00000105882
resolver
ensp
ENSMUSP00000105884
resolver
ensp
ENSMUSP00000105885
resolver
ensp
ENSMUSP00000105887
resolver
ensp
ENSMUSP00000105888
resolver
ensp
ENSMUSP00000299405
resolver
ensp
ENSMUSP00000299409
resolver
ensp
ENSMUSP00000299410
resolver
ensp
ENSMUSP00000299411
resolver
enst
ENSMUST00000110256
resolver
genesymbol
Marchf1
resolver
genesymbol_syn
March1
resolver
uniprot
D3YVY0
resolver
uniprot
Q3U7M8
resolver
uniprot
Q3UVF8
resolver
uniprot
Q8C294
resolver
uniprot
Q8CBA1
resolver
uniprot_entry
D3YVY0_MOUSE
resolver
uniprot_entry
MARH1_MOUSE
resolver
uniprot_sec
Q3U7M8
resolver
uniprot_sec
Q3UVF8
resolver
uniprot_sec
Q8C294
resolver
uniprot_sec
Q8CBA1
resolver
amino_acid_sequence
MLGWCEAIARNPHRIPNTTRTPETSGDVADASQTSTLNEKSPGRSASRSSNISKASSPTTGTAPRSQSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAVTCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTANKLEKNFPCNVNTEIKDAVVVPVPQTGSNTLPTAEGAPPEVIPV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies (PubMed:17051151, PubMed:17255932, PubMed:19880452). By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. Also regulates insulin sensitivity by controlling surface expression of the insulin receptor subunit beta/INSR by direct ubiquitination and degradation (PubMed:27577745). {ECO:0000269|PubMed:17051151, ECO:0000269|PubMed:17255932, ECO:0000269|PubMed:19880452, ECO:0000269|PubMed:19917682, ECO:0000269|PubMed:27577745}.
uniprot
proteins
mass_dalton
32347
uniprot
proteins
mutagenesis
MUTAGEN 114; /note="W->A: Loss of ubiquitin ligase activity and loss of down-regulation of CD86 cell surface expression."; /evidence="ECO:0000269|PubMed:19880452"; MUTAGEN 225; /note="L->S: Partial loss of down-regulation of CD86 cell surface expression. Almost complete loss of down-regulation of CD86 cell surface expression; when associated with F-232."; /evidence="ECO:0000269|PubMed:19880452"; MUTAGEN 232; /note="Y->F: Almost complete loss of down-regulation of CD86 cell surface expression; when associated with S-225."; /evidence="ECO:0000269|PubMed:19880452
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Has a short half-life. Instability/short half-life permits rapid changes that allow efficient induction of antigen presentation once antigen presenting cells, APCs, receive maturation signals. Small changes in protein levels significantly alter the cell surface display of MHC class II proteins.; PTM: Ubiquitinated via ubiquitin-conjugating enzyme E2 D1/UBE2D1 independently of lysines, leading to proteolytic degradation. {ECO:0000250|UniProtKB:Q8TCQ1}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17051151
uniprot
proteins
pubmed
17255932
uniprot
proteins
pubmed
19880452
uniprot
proteins
pubmed
19917682
uniprot
proteins
pubmed
27577745
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:19880452}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:19880452}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19880452}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:19880452}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 197..217; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins