Il6
entrez
16193
canonical
uniprot
P08505
canonical
ensembl
ENSMUSG00000025746
resolver
ensp
ENSMUSP00000026845
resolver
ensp
ENSMUSP00000143544
resolver
enst
ENSMUST00000026845
resolver
enst
ENSMUST00000195978
resolver
genesymbol
Il6
resolver
genesymbol_syn
Il-6
resolver
uniprot
A0A0G2JGF4
resolver
uniprot
A2RTD1
resolver
uniprot
Q3UCQ0
resolver
uniprot
Q8BN26
resolver
uniprot_entry
A0A0G2JGF4_MOUSE
resolver
uniprot_entry
A2RTD1_MOUSE
resolver
uniprot_entry
IL6_MOUSE
resolver
uniprot_sec
Q3UCQ0
resolver
uniprot_sec
Q8BN26
resolver
amino_acid_sequence
MKFLSARDFHPVAFLGLMLVTTTAFPTSQVRRGDFTEDTTPNRPVYTTSQVGGLITHVLWEIVEMRKELCNGNSDCMNNDDALAENNLKLPEIQRNDGCYQTGYNQEICLLKISSGLLEYHSYLEYMKNNLKDNKKDKARVLQRDTETLIHIFNQEVKDLHKIVLPTPISNALLTDKLESQKEWLRTKTIQFILKSLEEFLKVTLRSTRQT
uniprot
proteins
function
FUNCTION: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism (Probable). Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (PubMed:8910279). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (PubMed:27893700). {ECO:0000269|PubMed:27893700, ECO:0000269|PubMed:8910279, ECO:0000305|PubMed:30995492}.; FUNCTION: IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury. In the adaptive immune response, is required for the differentiation of B-cells into immunoglolin-secreting cells (Probable). Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Together with IL21, controls the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (PubMed:23045607). Required to drive naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells (PubMed:16990136, PubMed:27893700). Also required for proliferation of myeloma cells and the survival of plasmablast cells (Probable). {ECO:0000269|PubMed:16990136, ECO:0000269|PubMed:23045607, ECO:0000269|PubMed:27893700, ECO:0000305|PubMed:30995492}.; FUNCTION: Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF (PubMed:17075861). Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (PubMed:11786910). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (PubMed:28402851). Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (PubMed:11113088). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (PubMed:11113088, PubMed:8910279). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (PubMed:15124018). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity). {ECO:0000250|UniProtKB:P05231, ECO:0000269|PubMed:11113088, ECO:0000269|PubMed:11786910, ECO:0000269|PubMed:15124018, ECO:0000269|PubMed:17075861, ECO:0000269|PubMed:28402851, ECO:0000269|PubMed:8910279}.
uniprot
proteins
mass_dalton
24384
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated. {ECO:0000250|UniProtKB:P05231}.
uniprot
proteins
protein_family
IL-6 superfamily
uniprot
proteins
pubmed
11113088
uniprot
proteins
pubmed
11786910
uniprot
proteins
pubmed
15124018
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16990136
uniprot
proteins
pubmed
17075861
uniprot
proteins
pubmed
2106569
uniprot
proteins
pubmed
22037645
uniprot
proteins
pubmed
2243807
uniprot
proteins
pubmed
2302197
uniprot
proteins
pubmed
23045607
uniprot
proteins
pubmed
2563387
uniprot
proteins
pubmed
27893700
uniprot
proteins
pubmed
28265003
uniprot
proteins
pubmed
28402851
uniprot
proteins
pubmed
2948184
uniprot
proteins
pubmed
2965020
uniprot
proteins
pubmed
30995492
uniprot
proteins
pubmed
3262059
uniprot
proteins
pubmed
3262872
uniprot
proteins
pubmed
3263439
uniprot
proteins
pubmed
3264160
uniprot
proteins
pubmed
8910279
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27893700}.
uniprot
proteins