Nlgn3
entrez
245537
canonical
uniprot
Q8BYM5
canonical
ensembl
ENSMUSG00000031302
resolver
ensp
ENSMUSP00000066304
resolver
enst
ENSMUST00000065858
resolver
genesymbol
Nlgn3
resolver
uniprot
A2AGI1
resolver
uniprot
Q8BXR4
resolver
uniprot_entry
NLGN3_MOUSE
resolver
uniprot_sec
A2AGI1
resolver
uniprot_sec
Q8BXR4
resolver
amino_acid_sequence
MWLQPSLSLSPTPTVGRSLCLTLGFLSLVLRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAPGSWNGDQDAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGTGAPELGTAPEEELAALQLGPTHHECEAGPPHDTLRLTALPDYTLTLRRSPDDIPLMTPNTITMIPNSLVGLQTLHPYNTFAAGFNSTGLPHSHSTTRV
uniprot
proteins
function
FUNCTION: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. {ECO:0000269|PubMed:16982420, ECO:0000269|PubMed:30100184}.
uniprot
proteins
mass_dalton
91162
uniprot
proteins
mutagenesis
MUTAGEN 95; /note="N->A: N-glycosylation, localization to synapses, dendrites, and the cell membrane, as well as availability for trans-synaptic adhesion, are all impaired; when associated with A-522."; /evidence="ECO:0000269|PubMed:37865312"; MUTAGEN 522; /note="N->A: N-glycosylation, localization to synapses, dendrites, and the cell membrane, as well as availability for trans-synaptic adhesion, are all impaired; when associated with A-95."; /evidence="ECO:0000269|PubMed:37865312"; MUTAGEN 586..590; /note="KPRVR->APAVA: Reduced presynaptic differentiation."; /evidence="ECO:0000269|PubMed:30100184
uniprot
proteins
post_translational_modification
PTM: N-glycosylated, contains high-mannose, hybrid, complex and sialylated N-glycans. N-glycosylation is essential for localization to synapses, dendrites, and the cell membrane, and enhances its availability for trans-synaptic adhesion. O-glycosylated. {ECO:0000269|PubMed:37865312}.
uniprot
proteins
protein_family
Type-B carboxylesterase/lipase family
uniprot
proteins
pubmed
11329178
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16982420
uniprot
proteins
pubmed
17897391
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18434543
uniprot
proteins
pubmed
19243448
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19926856
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30100184
uniprot
proteins
pubmed
37865312
uniprot
proteins
sequence_length
825
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17897391, ECO:0000269|PubMed:37865312}; Single-pass type I membrane protein {ECO:0000255}. Synapse {ECO:0000269|PubMed:17897391, ECO:0000269|PubMed:37865312}. Cell projection, dendrite {ECO:0000269|PubMed:37865312}. Note=Detected at both glutamatergic and GABAergic synapses. Localizes to dendritic membrane. {ECO:0000269|PubMed:17897391, ECO:0000269|PubMed:37865312}.
uniprot
proteins
transmembrane_region
TRANSMEM 687..707; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins