Plcz1
entrez
114875
canonical
uniprot
Q8K4D7
canonical
ensembl
ENSMUSG00000030230
resolver
ensp
ENSMUSP00000032356
resolver
genesymbol
Plcz1
resolver
uniprot
Q3KPE5
resolver
uniprot_entry
PLCZ1_MOUSE
resolver
uniprot_sec
Q3KPE5
resolver
amino_acid_sequence
MESQLHELAEARWFLSKVQDDFRGGKINVEITHKLLEKLDFPCHFAHVKHIFKENDRQNQGRITIEEFRAIYRCIVHREEITEIFNTYTENRKILSENSLIEFLTQEQYEMEIDHSDSVEIINKYEPIEEVKGERQMSIEGFARYMFSSECLLFKENCKTVYQDMNHPLSDYFISSSHNTYLISDQILGPSDIWGYVSALVKGCRCLEIDCWDGSQNEPIVYHGYTFTSKLLFKTVVQAINKYAFVTSDYPVVLSLENHCSPGQQEVMASILQSTFGDFLLSDMLEEFPDTLPSPEALKFKILVKNRKVGTLSETHERIGTDKSGQVLEWKEVIYEDGDEDSGMDPETWDVFLSRIKEEREADPSTLSGIAGVKKRKRKMKIAMALSDLVIYTKAEKFRNFQYSRVYQQFNETNSIGESRARKLSKLRVHEFIFHTAAFITRVYPKMMRADSSNFNPQEFWNVGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPDILRDTTLGFNPNEPEYDDHPVTLTIRIISGIQLPVSSSSNTPDIVVIIEVYGVPNDHVKQQTRVVKNNAFSPKWNETFTFLIQVPELALIRFVVETQQGLLSGNELLGQYTLPVLCMNKGYRRVPLFSKSGANLEPSSLFIYVWYFRE
uniprot
proteins
ec_number
3.1.4.11
uniprot
proteins
function
FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. {ECO:0000250|UniProtKB:Q86YW0, ECO:0000269|PubMed:12117804, ECO:0000269|PubMed:14701816, ECO:0000269|PubMed:15159452, ECO:0000269|PubMed:15385165, ECO:0000269|PubMed:15790568, ECO:0000269|PubMed:16000311, ECO:0000269|PubMed:16854985, ECO:0000269|PubMed:17933795, ECO:0000269|PubMed:18028898, ECO:0000269|PubMed:18322275}.
uniprot
proteins
mass_dalton
74614
uniprot
proteins
mutagenesis
MUTAGEN 210; /note="D->R: Defective in Ca(2+) oscillation activity and shows slower nuclear translocation."; /evidence="ECO:0000269|PubMed:16854985"; MUTAGEN 299; /note="K->E: Defective in Ca(2+) oscillation activity and loss of nuclear translocation."; /evidence="ECO:0000269|PubMed:16854985"; MUTAGEN 301; /note="K->E: Defective in Ca(2+) oscillation activity and loss of nuclear translocation."; /evidence="ECO:0000269|PubMed:16854985"; MUTAGEN 376; /note="R->E: Abolishes nuclear translocation."; /evidence="ECO:0000269|PubMed:16854985"; MUTAGEN 377; /note="K->E: Abolishes nuclear translocation. Prolongs Ca(2+) oscillations allowing them to occur during interphase."; /evidence="ECO:0000269|PubMed:15159452, ECO:0000269|PubMed:16854985"; MUTAGEN 378; /note="R->E: Abolishes nuclear translocation."; /evidence="ECO:0000269|PubMed:16854985"; MUTAGEN 379; /note="K->E: Abolishes nuclear translocation."; /evidence="ECO:0000269|PubMed:16854985"; MUTAGEN 381; /note="K->E: Abolishes nuclear translocation."; /evidence="ECO:0000269|PubMed:16854985
uniprot
proteins
pubmed
12117804
uniprot
proteins
pubmed
14701816
uniprot
proteins
pubmed
15159452
uniprot
proteins
pubmed
15385165
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15790568
uniprot
proteins
pubmed
15809052
uniprot
proteins
pubmed
16000311
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16854985
uniprot
proteins
pubmed
17933795
uniprot
proteins
pubmed
18028898
uniprot
proteins
pubmed
18322275
uniprot
proteins
pubmed
35547809
uniprot
proteins
sequence_length
647
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14701816, ECO:0000269|PubMed:15159452, ECO:0000269|PubMed:15385165, ECO:0000269|PubMed:15809052, ECO:0000269|PubMed:18322275}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:14701816, ECO:0000269|PubMed:15159452, ECO:0000269|PubMed:15385165, ECO:0000269|PubMed:15809052, ECO:0000269|PubMed:18322275}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:35547809}. Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronuclei at interphase following meiosis and mitosis. Expressed at the acrosome and post-acrosome regions in spermatozoa (PubMed:35547809). {ECO:0000269|PubMed:14701816, ECO:0000269|PubMed:15159452, ECO:0000269|PubMed:15385165, ECO:0000269|PubMed:15809052, ECO:0000269|PubMed:18322275, ECO:0000269|PubMed:35547809}.
uniprot
proteins