Akr7a3
entrez
26760
canonical
uniprot
P38918
canonical
ensembl
ENSRNOG00000017899
resolver
ensp
ENSRNOP00000024160
resolver
genesymbol
Akr7a3
resolver
genesymbol_syn
Afar
resolver
genesymbol_syn
Akr7a1
resolver
uniprot
Q5EBB7
resolver
uniprot
Q68FZ3
resolver
uniprot
Q9QX16
resolver
uniprot_entry
ARK73_RAT
resolver
uniprot_sec
Q5EBB7
resolver
uniprot_sec
Q68FZ3
resolver
uniprot_sec
Q9QX16
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by citrate. {ECO:0000269|PubMed:11839745}.
uniprot
proteins
amino_acid_sequence
MSQARPATVLGAMEMGRRMDVTSSSASVRAFLQRGHTEIDTAFVYANGQSETILGDLGLGLGRSGCKVKIATKAAPMFGKTLKPADVRFQLETSLKRLQCPRVDLFYLHFPDHGTPIEETLQACHQLHQEGKFVELGLSNYVSWEVAEICTLCKKNGWIMPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGRYKYQDKDGKNPESRFFGNPFSQLYMDRYWKEEHFNGIALVEKALKTTYGPTAPSMISAAVRWMYHHSQLKGTQGDAVILGMSSLEQLEQNLALVEEGPLEPAVVDAFDQAWNLVAHECPNYFR
uniprot
proteins
ec_number
1.1.1.2
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of various carbonyl-containing compounds, including aldehydes, ketones, and toxic products from cellular metabolism or environmental exposure. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates, thus preventing the formation of protein adducts that contribute to AFB1-induced toxicity. {ECO:0000269|PubMed:10383892, ECO:0000269|PubMed:12071861}.
uniprot
proteins
mass_dalton
36747
uniprot
proteins
protein_family
Aldo/keto reductase 2 subfamily
uniprot
proteins
protein_family
Aldo/keto reductase family
uniprot
proteins
pubmed
10383892
uniprot
proteins
pubmed
11409944
uniprot
proteins
pubmed
11839745
uniprot
proteins
pubmed
12071861
uniprot
proteins
pubmed
12727802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8234296
uniprot
proteins
pubmed
8395332
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10383892}.
uniprot
proteins