FN3K
entrez
64122
canonical
uniprot
Q9H479
canonical
ensembl
ENSG00000167363
resolver
ensp
ENSP00000300784
resolver
enst
ENST00000300784
resolver
genesymbol
FN3K
resolver
hgnc
HGNC:24822
resolver
uniprot_entry
FN3K_HUMAN
resolver
amino_acid_sequence
MEQLLRAELRTATLRAFGGPGAGCISEGRAYDTDAGPVFVKVNRRTQARQMFEGEVASLEALRSTGLVRVPRPMKVIDLPGGGAAFVMEHLKMKSLSSQASKLGEQMADLHLYNQKLREKLKEEENTVGRRGEGAEPQYVDKFGFHTVTCCGFIPQVNEWQDDWPTFFARHRLQAQLDLIEKDYADREARELWSRLQVKIPDLFCGLEIVPALLHGDLWSGNVAEDDVGPIIYDPASFYGHSEFELAIALMFGGFPRSFFTAYHRKIPKAPGFDQRLLLYQLFNYLNHWNHFGREYRSPSLGTMRRLLK
uniprot
proteins
ec_number
2.7.1.171
uniprot
proteins
ec_number
2.7.1.172
uniprot
proteins
function
FUNCTION: Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:11522682, PubMed:11975663). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:11522682, PubMed:11975663). Involved in intracellular deglycation in erythrocytes (PubMed:11975663). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines (PubMed:14633848). {ECO:0000250|UniProtKB:Q9ER35, ECO:0000269|PubMed:11016445, ECO:0000269|PubMed:11522682, ECO:0000269|PubMed:11975663, ECO:0000269|PubMed:14633848}.
uniprot
proteins
mass_dalton
35171
uniprot
proteins
protein_family
Fructosamine kinase family
uniprot
proteins
pubmed
11016445
uniprot
proteins
pubmed
11522682
uniprot
proteins
pubmed
11975663
uniprot
proteins
pubmed
14633848
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
sequence_length
309
uniprot
proteins