Slc20a2
entrez
20516
canonical
uniprot
Q80UP8
canonical
ensembl
ENSMUSG00000037656
resolver
ensp
ENSMUSP00000065935
resolver
ensp
ENSMUSP00000306545
resolver
ensp
ENSMUSP00000306551
resolver
enst
ENSMUST00000067786
resolver
genesymbol
Slc20a2
resolver
genesymbol_syn
Pit2
resolver
uniprot
E9QLQ8
resolver
uniprot
Q3TBZ8
resolver
uniprot
Q9ES96
resolver
uniprot_entry
S20A2_MOUSE
resolver
uniprot_sec
E9QLQ8
resolver
uniprot_sec
Q3TBZ8
resolver
uniprot_sec
Q9ES96
resolver
amino_acid_sequence
MAMDGYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGPKGVQWMELVKIVASWFISPLLSGFMSGVLFILIRMFILTKEDPVPNGLQALPLFYAATIAINVFSIMYTGAPVLGLSLPIWAIALISFGVALLFAFFVWLFVCPWMKRKIAGRLEKESALSRASDESLRKVQEAESPGFKELPGAKPSDDSAVPLTSLAGEAVGASEGTSAGNHPRASYGRALSMTHGSAKSPISNGTFGFEGHMRNDGHVYHTVHKDSGLYKDLLHKIHVDRGSEEKPTQENNYRLLRRNNSYTCYTAAICGMPVHTTFRASDTSSAPEDSEKLVGDSVSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMRLASELADPDRPHEDPTEEEKEEKDSAEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYQQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAIMALLMYICGLFSSSR
uniprot
proteins
function
FUNCTION: Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11003594, PubMed:23968976, PubMed:26822507, PubMed:30721528). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (PubMed:30721528). Required to maintain normal cerebrospinal fluid phosphate levels (PubMed:26822507). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (PubMed:23968976). {ECO:0000269|PubMed:11003594, ECO:0000269|PubMed:23968976, ECO:0000269|PubMed:26822507, ECO:0000269|PubMed:30721528}.
uniprot
proteins
mass_dalton
70866
uniprot
proteins
protein_family
Inorganic phosphate transporter (PiT) (TC 2.A.20) family
uniprot
proteins
pubmed
11003594
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23968976
uniprot
proteins
pubmed
26822507
uniprot
proteins
pubmed
30721528
uniprot
proteins
sequence_length
656
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q63488}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q63488}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 191..211; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 484..504; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 532..552; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 573..587; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 595..610; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 623..643; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins