LGALS3
entrez
3958
canonical
uniprot
P17931
canonical
ensembl
ENSG00000131981
resolver
ensp
ENSP00000254301
resolver
ensp
ENSP00000558113
resolver
ensp
ENSP00000558114
resolver
ensp
ENSP00000558115
resolver
ensp
ENSP00000558116
resolver
ensp
ENSP00000558117
resolver
ensp
ENSP00000558118
resolver
ensp
ENSP00000558119
resolver
ensp
ENSP00000558121
resolver
ensp
ENSP00000558122
resolver
ensp
ENSP00000558123
resolver
ensp
ENSP00000558124
resolver
ensp
ENSP00000558125
resolver
ensp
ENSP00000558126
resolver
ensp
ENSP00000558127
resolver
ensp
ENSP00000558128
resolver
ensp
ENSP00000618010
resolver
ensp
ENSP00000618011
resolver
ensp
ENSP00000618012
resolver
ensp
ENSP00000618013
resolver
ensp
ENSP00000618014
resolver
ensp
ENSP00000618015
resolver
ensp
ENSP00000618016
resolver
enst
ENST00000254301
resolver
enst
ENST00000888054
resolver
enst
ENST00000888055
resolver
enst
ENST00000888056
resolver
enst
ENST00000888057
resolver
enst
ENST00000888058
resolver
enst
ENST00000888059
resolver
enst
ENST00000888060
resolver
enst
ENST00000888062
resolver
enst
ENST00000888063
resolver
enst
ENST00000888064
resolver
enst
ENST00000888065
resolver
enst
ENST00000888066
resolver
enst
ENST00000888067
resolver
enst
ENST00000888068
resolver
enst
ENST00000888069
resolver
enst
ENST00000947951
resolver
enst
ENST00000947952
resolver
enst
ENST00000947953
resolver
enst
ENST00000947954
resolver
enst
ENST00000947955
resolver
enst
ENST00000947956
resolver
enst
ENST00000947957
resolver
genesymbol
LGALS3
resolver
genesymbol_syn
MAC2
resolver
hgnc
HGNC:6563
resolver
uniprot
A0A024R693
resolver
uniprot
B2RC38
resolver
uniprot
Q16005
resolver
uniprot
Q6IBA7
resolver
uniprot
Q96J47
resolver
uniprot_entry
A0A024R693_HUMAN
resolver
uniprot_entry
LEG3_HUMAN
resolver
uniprot_sec
B2RC38
resolver
uniprot_sec
Q16005
resolver
uniprot_sec
Q6IBA7
resolver
uniprot_sec
Q96J47
resolver
amino_acid_sequence
MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDIDLTSASYTMI
uniprot
proteins
function
FUNCTION: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. {ECO:0000250, ECO:0000269|PubMed:15181153, ECO:0000269|PubMed:19594635, ECO:0000269|PubMed:19616076, ECO:0000269|PubMed:27693506}.
uniprot
proteins
mass_dalton
26152
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15181153
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19497882
uniprot
proteins
pubmed
19594635
uniprot
proteins
pubmed
19616076
uniprot
proteins
pubmed
2009535
uniprot
proteins
pubmed
2022338
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2261464
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2402511
uniprot
proteins
pubmed
24945728
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27693506
uniprot
proteins
pubmed
32272059
uniprot
proteins
pubmed
7682704
uniprot
proteins
pubmed
8253806
uniprot
proteins
pubmed
9439577
uniprot
proteins
pubmed
9501082
uniprot
proteins
pubmed
9582341
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32272059}. Nucleus. Secreted {ECO:0000269|PubMed:32272059}. Note=Secreted by a non-classical secretory pathway and associates with the cell surface. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). {ECO:0000269|PubMed:32272059}.
uniprot
proteins