COXFA4L2
entrez
56901
canonical
uniprot
Q9NRX3
canonical
ensembl
ENSG00000185633
resolver
ensp
ENSP00000377411
resolver
ensp
ENSP00000450664
resolver
enst
ENST00000393825
resolver
enst
ENST00000554503
resolver
genesymbol
COXFA4L2
resolver
genesymbol_syn
NDUFA4L2
resolver
hgnc
HGNC:29836
resolver
uniprot
Q6IAH9
resolver
uniprot_entry
CX4L2_HUMAN
resolver
uniprot_sec
Q6IAH9
resolver
amino_acid_sequence
MAGASLGARFYRQIKRHPGIIPMIGLICLGMGSAALYLLRLALRSPDVCWDRKNNPEPWNRLSPNDQYKFLAVSTDYKKLKKDRPDF
uniprot
proteins
function
FUNCTION: Mitochondrial protein that plays a regulatory role in cellular metabolism, particularly under hypoxic conditions (PubMed:22100406). Down-regulates mitochondrial respiratory chain complex I activity under hypoxia, reduces oxygen consumption and ROS and helps cells adapt by switching to glycolysis (PubMed:22100406). {ECO:0000269|PubMed:22100406}.
uniprot
proteins
mass_dalton
9966
uniprot
proteins
protein_family
Complex IV COXFA4 subunit family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22100406
uniprot
proteins
sequence_length
87
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:22100406}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins