Prdx6
entrez
11758
canonical
uniprot
O08709
canonical
ensembl
ENSMUSG00000026701
resolver
ensp
ENSMUSP00000050703
resolver
ensp
ENSMUSP00000071636
resolver
enst
ENSMUST00000051925
resolver
enst
ENSMUST00000071718
resolver
genesymbol
Prdx6
resolver
genesymbol_syn
Aop2
resolver
genesymbol_syn
Ltw4
resolver
genesymbol_syn
Prdx5
resolver
uniprot
D3Z0Y2
resolver
uniprot
F6X233
resolver
uniprot
Q6GT24
resolver
uniprot
Q91WT2
resolver
uniprot
Q9QWP4
resolver
uniprot
Q9QWW0
resolver
uniprot_entry
D3Z0Y2_MOUSE
resolver
uniprot_entry
F6X233_MOUSE
resolver
uniprot_entry
PRDX6_MOUSE
resolver
uniprot_entry
Q6GT24_MOUSE
resolver
uniprot_sec
Q91WT2
resolver
uniprot_sec
Q9QWP4
resolver
uniprot_sec
Q9QWW0
resolver
activity_regulation
ACTIVITY REGULATION: MJ33 or lithium;[(2R)-1-hexadecoxy-3-(2,2,2-trifluoroethoxy)propan-2-yl] methyl phosphate inhibits its phospholipase A2 activity (PubMed:26830860). CI-976 or 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide inhibits its lysophosphatidylcholine acyltransferase activity (PubMed:26830860). {ECO:0000269|PubMed:26830860}.
uniprot
proteins
amino_acid_sequence
MPGGLLLGDEAPNFEANTTIGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNGETPTEKLPFPIIDDKGRDLAILLGMLDPVEKDDNNMPVTARVVFIFGPDKKLKLSILYPATTGRNFDEILRVVDSLQLTGTKPVATPVDWKKGESVMVVPTLSEEEAKQCFPKGVFTKELPSGKKYLRYTPQP
uniprot
proteins
ec_number
1.11.1.27
uniprot
proteins
ec_number
2.3.1.23
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (By similarity). Has phospholipase activity (PubMed:26830860). Can either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (By similarity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity). {ECO:0000250|UniProtKB:P30041, ECO:0000269|PubMed:26830860}.
uniprot
proteins
mass_dalton
24871
uniprot
proteins
mutagenesis
MUTAGEN 26; /note="H->A: Loss of phospholipase activity, but no effect on lysophosphatidylcholine acyltransferase activity."; /evidence="ECO:0000269|PubMed:26830860"; MUTAGEN 31; /note="D->A: Loss of lysophosphatidylcholine acyltransferase activity, but no effect on phospholipase activity."; /evidence="ECO:0000269|PubMed:26830860"; MUTAGEN 32; /note="S->A: Loss of phospholipase activity, but no effect on lysophosphatidylcholine acyltransferase activity."; /evidence="ECO:0000269|PubMed:26830860"; MUTAGEN 47; /note="C->S: No loss of phospholipase or lysophosphatidylcholine acyltransferase activity."; /evidence="ECO:0000269|PubMed:26830860"; MUTAGEN 140; /note="D->A: Loss of phospholipase activity, but no effect on lysophosphatidylcholine acyltransferase activity."; /evidence="ECO:0000269|PubMed:26830860
uniprot
proteins
post_translational_modification
PTM: Irreversibly inactivated by overoxidation of Cys-47 to sulfinic acid (Cys-SO(2)H) and sulfonic acid (Cys-SO(3)H) forms upon oxidative stress. {ECO:0000250|UniProtKB:P30041}.; PTM: Phosphorylation at Thr-177 by MAP kinases increases the phospholipase activity of the enzyme (By similarity). The phosphorylated form exhibits a greater lysophosphatidylcholine acyltransferase activity compared to the non-phosphorylated form (By similarity). {ECO:0000250|UniProtKB:O35244}.
uniprot
proteins
protein_family
Peroxiredoxin family
uniprot
proteins
protein_family
Prx6 subfamily
uniprot
proteins
pubmed
10395907
uniprot
proteins
pubmed
14988405
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
26830860
uniprot
proteins
pubmed
9205120
uniprot
proteins
pubmed
9291135
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O35244}. Lysosome {ECO:0000250|UniProtKB:O35244}. Note=Also found in lung secretory organelles (lamellar bodies). {ECO:0000250|UniProtKB:O35244}.
uniprot
proteins