RENBP
entrez
5973
canonical
uniprot
P51606
canonical
ensembl
ENSG00000102032
resolver
ensp
ENSP00000377303
resolver
genesymbol
RENBP
resolver
hgnc
HGNC:9959
resolver
uniprot
B4DNZ3
resolver
uniprot
Q96BI6
resolver
uniprot_entry
RENBP_HUMAN
resolver
uniprot_sec
B4DNZ3
resolver
uniprot_sec
Q96BI6
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethylmaleimide, 5,5'-dithiobis-2-nitrobenzoate and iodoacetic acid. {ECO:0000269|PubMed:10502668}.
uniprot
proteins
amino_acid_sequence
MSKGLPARQDMEKERETLQAWKERVGQELDRVVAFWMEHSHDQEHGGFFTCLGREGRVYDDLKYVWLQGRQVWMYCRLYRTFERFRHAQLLDAAKAGGEFLLRYARVAPPGKKCAFVLTRDGRPVKVQRTIFSECFYTMAMNELWRATGEVRYQTEAVEMMDQIVHWVQEDASGLGRPQLQGAPAAEPMAVPMMLLNLVEQLGEADEELAGKYAELGDWCARRILQHVQRDGQAVLENVSEGGKELPGCLGRQQNPGHTLEAGWFLLRHCIRKGDPELRAHVIDKFLLLPFHSGWDPDHGGLFYFQDADNFCPTQLEWAMKLWWPHSEAMIAFLMGYSDSGDPVLLRLFYQVAEYTFRQFRDPEYGEWFGYLSREGKVALSIKGGPFKGCFHVPRCLAMCEEMLGALLSRPAPAPSPAPTPACRGAE
uniprot
proteins
ec_number
5.1.3.8
uniprot
proteins
function
FUNCTION: Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine (PubMed:10502668, PubMed:12499362, PubMed:9990133). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (PubMed:9990133). {ECO:0000269|PubMed:10502668, ECO:0000269|PubMed:12499362, ECO:0000269|PubMed:9990133}.
uniprot
proteins
mass_dalton
48831
uniprot
proteins
mutagenesis
MUTAGEN 51; /note="C->S: Activity is similiar to wild-type."; /evidence="ECO:0000269|PubMed:10502668"; MUTAGEN 76; /note="C->S: Activity is similiar to wild-type."; /evidence="ECO:0000269|PubMed:10502668"; MUTAGEN 114; /note="C->S: Activity is about 26% of that of the wild-type."; /evidence="ECO:0000269|PubMed:10502668"; MUTAGEN 135; /note="C->S: Activity is similiar to wild-type."; /evidence="ECO:0000269|PubMed:10502668"; MUTAGEN 220; /note="C->S: Activity is similiar to wild-type."; /evidence="ECO:0000269|PubMed:10502668"; MUTAGEN 249; /note="C->S: Activity is similiar to wild-type."; /evidence="ECO:0000269|PubMed:10502668"; MUTAGEN 312; /note="C->S: Activity is similiar to wild-type."; /evidence="ECO:0000269|PubMed:10502668"; MUTAGEN 390; /note="C->S: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:10502668"; MUTAGEN 396; /note="C->S: Activity is similiar to wild-type."; /evidence="ECO:0000269|PubMed:10502668"; MUTAGEN 400; /note="C->S: Activity is similiar to wild-type."; /evidence="ECO:0000269|PubMed:10502668
uniprot
proteins
pathway_participation
PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation. {ECO:0000269|PubMed:22692205}.
uniprot
proteins
protein_family
N-acylglucosamine 2-epimerase (AGE) family
uniprot
proteins
pubmed
10502668
uniprot
proteins
pubmed
12499362
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
1723410
uniprot
proteins
pubmed
22692205
uniprot
proteins
pubmed
9990133
uniprot
proteins
sequence_length
427
uniprot
proteins