Tp53inp2
entrez
68728
canonical
uniprot
Q8CFU8
canonical
ensembl
ENSMUSG00000038375
resolver
ensp
ENSMUSP00000037627
resolver
ensp
ENSMUSP00000133880
resolver
ensp
ENSMUSP00000296812
resolver
ensp
ENSMUSP00000296816
resolver
ensp
ENSMUSP00000296821
resolver
ensp
ENSMUSP00000296822
resolver
genesymbol
Tp53inp2
resolver
genesymbol_syn
Dor
resolver
genesymbol_syn
Trp53inp2
resolver
uniprot
Q3TDL6
resolver
uniprot
Q711P5
resolver
uniprot
Q8CHM4
resolver
uniprot_entry
T53I2_MOUSE
resolver
uniprot_sec
Q3TDL6
resolver
uniprot_sec
Q711P5
resolver
uniprot_sec
Q8CHM4
resolver
amino_acid_sequence
MFQRFTSLFFNTPAPPEDSNCPGAFVSEEDEVDGWLIIDLQDSYTAPPDPGASPAPAGRPPPAPSLMDESWFVTPPACFTAEGPGLGPARLQSNPLEDLLIEHPSMSVYVTGSTIVLESGPPSPHPEAALPDQDLSDGELAPALREPRALHHAAAPMPARAVLLEKAGQVRRLQRARQRAERHTLSAKVLQRQNRARESRSRRPKHQGSFIYQPCQRQFNY
uniprot
proteins
function
FUNCTION: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA. {ECO:0000269|PubMed:18030323}.
uniprot
proteins
mass_dalton
24288
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18030323
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation. {ECO:0000250}.
uniprot
proteins