H2az1
entrez
51788
canonical
uniprot
P0C0S6
canonical
ensembl
ENSMUSG00000037894
resolver
ensp
ENSMUSP00000036907
resolver
ensp
ENSMUSP00000134059
resolver
enst
ENSMUST00000041045
resolver
enst
ENSMUST00000174561
resolver
genesymbol
H2az1
resolver
genesymbol_syn
H2afz
resolver
genesymbol_syn
H2az
resolver
uniprot
B2RXZ3
resolver
uniprot
G3UYF1
resolver
uniprot
P17317
resolver
uniprot
Q3UA55
resolver
uniprot
Q3UA95
resolver
uniprot
Q3UK43
resolver
uniprot
Q68FD2
resolver
uniprot_entry
G3UYF1_MOUSE
resolver
uniprot_entry
H2AZ_MOUSE
resolver
uniprot_entry
Q3UA95_MOUSE
resolver
uniprot_sec
B2RXZ3
resolver
uniprot_sec
P17317
resolver
uniprot_sec
Q3UA55
resolver
uniprot_sec
Q3UK43
resolver
uniprot_sec
Q68FD2
resolver
amino_acid_sequence
MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV
uniprot
proteins
function
FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. Essential for early development. {ECO:0000269|PubMed:11516949, ECO:0000269|PubMed:15195148, ECO:0000269|PubMed:15546624}.
uniprot
proteins
mass_dalton
13553
uniprot
proteins
post_translational_modification
PTM: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression. {ECO:0000250|UniProtKB:P0C0S5}.; PTM: Acetylated on Lys-5, Lys-8, Lys-12 and Lys-14 by KAT2A; KAT2A is recruited by the XPC complex in absence of DNA damage (By similarity). Acetylated on Lys-5, Lys-8 and Lys-12 during interphase; acetylation disappears at mitosis (PubMed:16204459, PubMed:7217105). Acetylation by the NuA4 histone acetyltransferase complex is required for hematopoietic stem cell maintenance (PubMed:32542325). {ECO:0000250|UniProtKB:P0C0S5, ECO:0000269|PubMed:16204459, ECO:0000269|PubMed:32542325, ECO:0000269|PubMed:7217105}.; PTM: Not phosphorylated. {ECO:0000269|PubMed:7217105}.; PTM: Monomethylated on Lys-5 and Lys-8 by SETD6. SETD6 predominantly methylates Lys-8, lys-5 being a possible secondary site. {ECO:0000250|UniProtKB:P0C0S5}.; PTM: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. {ECO:0000250|UniProtKB:P0C0S5}.
uniprot
proteins
protein_family
Histone H2A family
uniprot
proteins
pubmed
11516949
uniprot
proteins
pubmed
12660166
uniprot
proteins
pubmed
15195148
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15546624
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16204459
uniprot
proteins
pubmed
30842416
uniprot
proteins
pubmed
31645732
uniprot
proteins
pubmed
32542325
uniprot
proteins
pubmed
7217105
uniprot
proteins
sequence_length
128
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12660166}. Chromosome {ECO:0000269|PubMed:12660166, ECO:0000269|PubMed:15195148}. Note=Enriched in constitutive heterochromatin (PubMed:12660166, PubMed:15195148). Absent from facultative heterochromatin of the inactive X chromosome (PubMed:12660166). {ECO:0000269|PubMed:12660166, ECO:0000269|PubMed:15195148}.
uniprot
proteins