SLC8B1
entrez
80024
canonical
uniprot
Q6J4K2
canonical
ensembl
ENSG00000089060
resolver
ensp
ENSP00000202831
resolver
ensp
ENSP00000450081
resolver
ensp
ENSP00000506377
resolver
genesymbol
SLC8B1
resolver
genesymbol_syn
NCKX6
resolver
genesymbol_syn
NCLX
resolver
genesymbol_syn
SLC24A6
resolver
hgnc
HGNC:26175
resolver
uniprot
A6NP50
resolver
uniprot
Q4KMS9
resolver
uniprot
Q6J4K1
resolver
uniprot
Q9H6I8
resolver
uniprot_entry
NCLX_HUMAN
resolver
uniprot_sec
A6NP50
resolver
uniprot_sec
Q4KMS9
resolver
uniprot_sec
Q6J4K1
resolver
uniprot_sec
Q9H6I8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the sodium/calcium exchanger inhibitor CGP-37157 (PubMed:24898248). Strongly inhibited by zinc (PubMed:15060069). {ECO:0000269|PubMed:15060069, ECO:0000269|PubMed:24898248}.
uniprot
proteins
amino_acid_sequence
MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLNVSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
uniprot
proteins
function
FUNCTION: Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:15060069, PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28130126, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Mitochondrial calcium export is ph-dependent (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (PubMed:15060069, PubMed:28130126). In contrast to other members of the family its function is independent of K(+) (PubMed:15060069). {ECO:0000250|UniProtKB:Q6AXS0, ECO:0000250|UniProtKB:Q925Q3, ECO:0000269|PubMed:15060069, ECO:0000269|PubMed:20018762, ECO:0000269|PubMed:22829870, ECO:0000269|PubMed:23056385, ECO:0000269|PubMed:24898248, ECO:0000269|PubMed:28219928}.
uniprot
proteins
mass_dalton
64231
uniprot
proteins
mutagenesis
MUTAGEN 149; /note="N->A: Lithium-selective; displays reduced calcium:sodium antiporter activity while retaining almost normal calcium:lithium antiporter activity."; /evidence="ECO:0000269|PubMed:28130126"; MUTAGEN 152; /note="P->A: Lithium-selective; displays markedly reduced calcium:sodium antiporter activity while retaining almost normal calcium:lithium antiporter activity."; /evidence="ECO:0000269|PubMed:28130126"; MUTAGEN 153; /note="D->A: Lithium-selective; displays markedly reduced calcium:sodium antiporter activity while retaining almost normal calcium:lithium antiporter activity."; /evidence="ECO:0000269|PubMed:28130126"; MUTAGEN 176; /note="G->A: Non-selective; displays similar reduction of calcium:sodium and calcium:lithium antiporter activities."; /evidence="ECO:0000269|PubMed:28130126"; MUTAGEN 258; /note="S->A: Abolished ability to prevent calcium overload."; /evidence="ECO:0000269|PubMed:26440884"; MUTAGEN 258; /note="S->D: Phosphomimetic mutant; prevents calcium overload."; /evidence="ECO:0000269|PubMed:26440884"; MUTAGEN 467; /note="N->A: Has no effect on calcium:sodium antiporter activity."; /evidence="ECO:0000269|PubMed:28130126"; MUTAGEN 467; /note="N->Q: Lithium-selective; displays markedly reduced calcium:sodium antiporter activity while retaining normal calcium:lithium antiporter activity."; /evidence="ECO:0000269|PubMed:28130126"; MUTAGEN 468; /note="S->T: Lithium-selective; displays markedly reduced calcium:sodium antiporter activity while retaining almost normal calcium:lithium antiporter activity."; /evidence="ECO:0000269|PubMed:28130126"; MUTAGEN 471; /note="D->A: Sodium-selective; has little effect on calcium:sodium antiporter activity while displaying markedly reduced calcium:lithium antiporter activity."; /evidence="ECO:0000269|PubMed:28130126"; MUTAGEN 471; /note="D->E: Non-selective; displays reduction of both calcium:sodium and calcium:lithium antiporter activities."; /evidence="ECO:0000269|PubMed:28130126"; MUTAGEN 494; /note="G->S: Lithium-selective; displays markedly reduced calcium:sodium antiporter activity while retaining almost normal calcium:lithium antiporter activity."; /evidence="ECO:0000269|PubMed:28130126"; MUTAGEN 498; /note="N->A: Non-selective; displays similar reduction of calcium:sodium and calcium:lithium antiporter activities."; /evidence="ECO:0000269|PubMed:28130126
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-258 by PKA prevents calcium overload. {ECO:0000269|PubMed:26440884}.
uniprot
proteins
protein_family
Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family
uniprot
proteins
protein_family
SLC24A subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15060069
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
20018762
uniprot
proteins
pubmed
22829870
uniprot
proteins
pubmed
23056385
uniprot
proteins
pubmed
24898248
uniprot
proteins
pubmed
26440884
uniprot
proteins
pubmed
28130126
uniprot
proteins
pubmed
28219928
uniprot
proteins
pubmed
40200126
uniprot
proteins
sequence_length
584
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:20018762, ECO:0000269|PubMed:23056385}; Multi-pass membrane protein {ECO:0000269|PubMed:20018762, ECO:0000269|PubMed:23056385}.
uniprot
proteins
transmembrane_region
TRANSMEM 96..132; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 137..162; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 166..192; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 200..221; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 227..255; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 356..373; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 389..409; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 418..450; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 455..480; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 485..514; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 526..548; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q6AXS0"; TRANSMEM 554..575; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q6AXS0
uniprot
proteins