Exosc5
entrez
27998
canonical
uniprot
Q9CRA8
canonical
ensembl
ENSMUSG00000061286
resolver
ensp
ENSMUSP00000078580
resolver
ensp
ENSMUSP00000145948
resolver
enst
ENSMUST00000079634
resolver
enst
ENSMUST00000206561
resolver
genesymbol
Exosc5
resolver
genesymbol_syn
D7Wsu180e
resolver
genesymbol_syn
Rrp46
resolver
uniprot
Q8K1J2
resolver
uniprot_entry
EXOS5_MOUSE
resolver
uniprot_sec
Q8K1J2
resolver
amino_acid_sequence
MEGAKRADANLLTDTGTESSPRSPVCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRERLVRNTCEAVVLGALHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVTCALDSDGNLVLDPTTKQEKEARAILTFALDSAEQKLLMSTTKGLYSDAELQQCLAAAQAASQHIFRFYRESLQRRYSKS
uniprot
proteins
function
FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity). In vitro, EXOSC5 does not bind or digest single-stranded RNA and binds to double-stranded DNA without detectable DNase activity (By similarity). {ECO:0000250|UniProtKB:Q9NQT4}.
uniprot
proteins
mass_dalton
25194
uniprot
proteins
protein_family
RNase PH family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9NQT4}. Cytoplasm {ECO:0000250|UniProtKB:Q9NQT4}. Nucleus {ECO:0000250|UniProtKB:Q9NQT4}.
uniprot
proteins