Rnf25
entrez
57751
canonical
uniprot
Q9QZR0
canonical
ensembl
ENSMUSG00000026171
resolver
ensp
ENSMUSP00000027357
resolver
ensp
ENSMUSP00000109350
resolver
enst
ENSMUST00000027357
resolver
enst
ENSMUST00000113721
resolver
genesymbol
Rnf25
resolver
uniprot
E9Q446
resolver
uniprot
Q3TAL8
resolver
uniprot
Q9CT51
resolver
uniprot
Q9DCW7
resolver
uniprot_entry
E9Q446_MOUSE
resolver
uniprot_entry
Q9CT51_MOUSE
resolver
uniprot_entry
RNF25_MOUSE
resolver
uniprot_sec
Q3TAL8
resolver
uniprot_sec
Q9DCW7
resolver
amino_acid_sequence
MAASASTAAGEEDWVLPSEVEVLESIYLDELQVMKGNGRSPWEIFITLHPATAEVQDSQFVCFTLVLRIPVQYPHEVPQISIRNPRGLSDEQIHKISQALGHVAKEGLGTAMLYELIEKGKEILTDNNIPHGQCVICLYGFQEKEAFTKTPCYHYFHCHCLARYIQHMEQELTTQEQEQERQHVVTKQKAVGVQCPVCREPLVYDLASLKAAPEPQQPMELYQPSAESLRQQEELKLLYQRQQEKGGIIDLEAERNRYFISLQQPPAALEPESAVDVSREPQPPNALSAEQSTSLADQSTLPTSLPMTTQYTYEKTSGAGPNQQRPGETQKSVLDPPRHGRGSWRQYDRRHPKGGECCTPKGTSEIHELPPPEKPLKETVDLKAEPRNKGLTGHPQEKGPGSWQGPSARRTRDCARWERSKNRTPGSCYPHLPRGQGAYRSGTRREPLGLESEEGS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity). Catalyzes ubiquitination of RPS27A in response to ribosome collisions, promoting activation of RNF14 (By similarity). RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes, such as RPL0, RPL1, RPL12, RPS13 and RPS17 (By similarity). Also involved in ubiquitination and degradation of stalled ETF1/eRF1 (By similarity). Independently of its function in the response to stalled ribosomes, mediates ubiquitination and subsequent proteasomal degradation of NKD2 (PubMed:10500182, PubMed:18757723). May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65 (By similarity). {ECO:0000250|UniProtKB:Q96BH1, ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:18757723}.
uniprot
proteins
mass_dalton
51227
uniprot
proteins
mutagenesis
MUTAGEN 134; /note="C->S: No E2 binding. Loss of ubiquitination activity."; /evidence="ECO:0000269|PubMed:10500182"; MUTAGEN 137; /note="C->S: No E2 binding. Loss of ubiquitination activity."; /evidence="ECO:0000269|PubMed:10500182"; MUTAGEN 152; /note="C->S: No E2 binding. Loss of ubiquitination activity."; /evidence="ECO:0000269|PubMed:10500182"; MUTAGEN 157; /note="H->C: No E2 binding. Loss of ubiquitination activity."; /evidence="ECO:0000269|PubMed:10500182"; MUTAGEN 158; /note="C->S: No E2 binding. Loss of ubiquitination activity."; /evidence="ECO:0000269|PubMed:10500182"; MUTAGEN 160; /note="C->S: No E2 binding. Loss of ubiquitination activity."; /evidence="ECO:0000269|PubMed:10500182
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:18757723}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; autoubiquitinated. {ECO:0000250|UniProtKB:Q96BH1}.
uniprot
proteins
protein_family
RNF25 family
uniprot
proteins
pubmed
10500182
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18757723
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7SXJ6}.
uniprot
proteins