Arhgef1
entrez
16801
canonical
uniprot
Q61210
canonical
ensembl
ENSMUSG00000040940
resolver
ensp
ENSMUSP00000046469
resolver
ensp
ENSMUSP00000096280
resolver
ensp
ENSMUSP00000113366
resolver
ensp
ENSMUSP00000113771
resolver
ensp
ENSMUSP00000146314
resolver
ensp
ENSMUSP00000261556
resolver
ensp
ENSMUSP00000261559
resolver
ensp
ENSMUSP00000261561
resolver
ensp
ENSMUSP00000261564
resolver
ensp
ENSMUSP00000261568
resolver
ensp
ENSMUSP00000261573
resolver
ensp
ENSMUSP00000261582
resolver
ensp
ENSMUSP00000261583
resolver
ensp
ENSMUSP00000261584
resolver
ensp
ENSMUSP00000261594
resolver
ensp
ENSMUSP00000345496
resolver
enst
ENSMUST00000117796
resolver
genesymbol
Arhgef1
resolver
genesymbol_syn
Lbcl2
resolver
genesymbol_syn
Lsc
resolver
uniprot
E9PUF7
resolver
uniprot
O89074
resolver
uniprot
Q3T9Q7
resolver
uniprot
Q80YE8
resolver
uniprot
Q80YE9
resolver
uniprot
Q91VL3
resolver
uniprot_entry
ARHG1_MOUSE
resolver
uniprot_entry
E9PUF7_MOUSE
resolver
uniprot_sec
O89074
resolver
uniprot_sec
Q3T9Q7
resolver
uniprot_sec
Q80YE8
resolver
uniprot_sec
Q80YE9
resolver
uniprot_sec
Q91VL3
resolver
amino_acid_sequence
MGEVAGGAAPGPPRSGLVSIIIGAEDEDFENELEANSEDQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLLCCLHADMLSSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPSVAFELDRTRPDLISEDVQRRFIQEVVQSQQAAVSRQLEDFRSKRLMGMTPWEQELSLLEPWIGKDRGNYEARERHVAERLLSHLEETQHTISTDEEKSAAVVTAISLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPPKTKKGLSSILDPARWNRGEPSAPDCRHLKVEADAEKPGPADRKGGLGMSSRDRTVGTPGQDNPGVSLHPLSTDSVDSREPGVDTPQEPGDTPPQGPTSLEPLAPPESTEDNGETESPEPGDDGEPGRSGLELEPEEPPGWRELVPPDTLLSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFYQPMADGGFFPLDELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKEPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEESTERGKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLTHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAIEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVIFTWDQEAQIYELVAQTSSERKNWCNLITETAGSLKVPAPASRLKPRPSPSSIREPLLSSSENGTGGAEMAPADARTERLLNDLLPFCRPGPEGQLAATALQKVLSLKQILLSTEEDSGAGPPRDGDGVPGGRAPGPVHTQEIEENLLSLEVAIRQLEELEEEFCRLRPLLSQLGGTLSPNLAAPERSAQTGLS
uniprot
proteins
function
FUNCTION: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. Isoform 3 and isoform 4 do not homooligomerize and show an enhanced RhoGEF activity. In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:25274307, ECO:0000269|PubMed:8910315}.
uniprot
proteins
mass_dalton
102805
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKCA (By similarity). Angiotensin-2 induced Tyr-737 phosphorylation is mediated by JAK2. Isoform 5 is phosphorylated at 'Ser-390'. {ECO:0000250, ECO:0000269|PubMed:20098430}.
uniprot
proteins
pubmed
12773540
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17000758
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
20098430
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25274307
uniprot
proteins
pubmed
8702517
uniprot
proteins
pubmed
8910315
uniprot
proteins
pubmed
9798653
uniprot
proteins
sequence_length
920
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Translocated to the membrane by activated GNA13 or LPA stimulation. {ECO:0000250}.
uniprot
proteins