Ldah
entrez
313949
canonical
uniprot
Q5HZX7
canonical
ensembl
ENSRNOG00000021475
resolver
ensembl
ENSRNOG00055005680
resolver
ensembl
ENSRNOG00060003575
resolver
ensembl
ENSRNOG00065005269
resolver
ensp
ENSRNOP00000033708
resolver
ensp
ENSRNOP00055006994
resolver
ensp
ENSRNOP00060004279
resolver
ensp
ENSRNOP00065005407
resolver
enst
ENSRNOT00000030244
resolver
enst
ENSRNOT00055009151
resolver
enst
ENSRNOT00060005857
resolver
enst
ENSRNOT00065007777
resolver
genesymbol
Ldah
resolver
uniprot_entry
LDAH_RAT
resolver
amino_acid_sequence
MASEVEDGVPVHEEFFLCGGVETQIIKCGPWTNLFDKQGVSKPKHLIFVIPGNPGLSPFYVPFAKALYSLVKGHFPVWIISHAGFCLTPKDKKILTAPQEPNAQEIEDIYGLNGQIEHKIAFLRAHVPKDVKLIFIGHSVGSYIALHVMNRAPELPVVHTFLLFPTIERMSESPNGKFATPFLCRFRYMLYAASYLIFKPCPEMIKSFIVQKVLEKMSFKSELRLTDLLQPFCLANAAYLGGQEMIHVVKRDDGIIKELLPKLTFYYGKTDGWCPVNYYEDMKRDFPEANLHLCEKGIPHAFVLGFSQEMAAMVADWINNRLPKK
uniprot
proteins
ec_number
3.1.1.13
uniprot
proteins
function
FUNCTION: Probable serine lipid hydrolase associated with lipid droplets. Has low cholesterol esterase activity. Appears to lack triglyceride lipase activity. Involved in cholesterol and triglyceride homeostasis; stimulates cellular triglyceride accumulation and cellular cholesterol release. Acts antagonistically with PNPLA2/ATGL in regulation of cellular lipid stores. May regulate triglyceride accumulation indirectly through stimulation of PNPLA2/ATGL ubiquitination and proteasomal degradation. Promotes microtubule-dependent lipid droplet fusion. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages. {ECO:0000250|UniProtKB:Q8BVA5}.
uniprot
proteins
mass_dalton
36881
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
LDAH family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lipid droplet {ECO:0000250|UniProtKB:Q8BVA5}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8BVA5}. Note=Localizes to the endoplasmic reticulum in absence of lipid droplets and translocates to lipid droplets upon lipid storage induction (By similarity). Lipid droplet localization does not require hydrolase activity (By similarity). {ECO:0000250|UniProtKB:Q8BVA5}.
uniprot
proteins