Trpc1
entrez
89821
canonical
uniprot
Q9QX01
canonical
ensembl
ENSRNOG00000054902
resolver
ensp
ENSRNOP00000072139
resolver
ensp
ENSRNOP00000074229
resolver
genesymbol
Trpc1
resolver
genesymbol_syn
Trp1
resolver
uniprot_entry
TRPC1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G protein coupled receptors (By similarity). Also activated by intracellular calcium store depletion (By similarity). {ECO:0000250|UniProtKB:P48995}.
uniprot
proteins
amino_acid_sequence
MMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENESLDILQLLLDYGCQKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVALPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFWNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWVCSHTSKGKVRRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPKN
uniprot
proteins
function
FUNCTION: Forms a receptor-activated non-selective calcium permeant cation channel. Forms a heteromeric ion channel with TRPC4 or TRPC5 that has reduced calcium permeability compared to the homomeric TRPC4 or TRPC5 channel (By similarity). Also permeable to monovalent ions including sodium, lithium and cesium ions (By similarity). {ECO:0000250|UniProtKB:P48995}.
uniprot
proteins
mass_dalton
87618
uniprot
proteins
post_translational_modification
PTM: Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells. {ECO:0000250|UniProtKB:P48995}.
uniprot
proteins
protein_family
STrpC subfamily
uniprot
proteins
protein_family
TRPC1 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
10199829
uniprot
proteins
pubmed
11301024
uniprot
proteins
sequence_length
759
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P48995}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48995}.
uniprot
proteins
transmembrane_region
TRANSMEM 353..370; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:P48995"; TRANSMEM 389..405; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:P48995"; TRANSMEM 422..441; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:P48995"; TRANSMEM 463..483; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:P48995"; TRANSMEM 503..524; /note="Helical; Name=S5"; /evidence="ECO:0000250|UniProtKB:P48995"; TRANSMEM 590..610; /note="Helical; Name=S6"; /evidence="ECO:0000250|UniProtKB:P48995
uniprot
proteins