Rgs7
entrez
54296
canonical
uniprot
P49803
canonical
ensembl
ENSRNOG00000021984
resolver
ensembl
ENSRNOG00055022991
resolver
ensembl
ENSRNOG00060027170
resolver
ensembl
ENSRNOG00065022162
resolver
ensp
ENSRNOP00000076773
resolver
ensp
ENSRNOP00000090982
resolver
ensp
ENSRNOP00000094085
resolver
ensp
ENSRNOP00055032125
resolver
ensp
ENSRNOP00060039417
resolver
ensp
ENSRNOP00065030551
resolver
enst
ENSRNOT00000106278
resolver
enst
ENSRNOT00000107041
resolver
enst
ENSRNOT00000112294
resolver
enst
ENSRNOT00055039554
resolver
enst
ENSRNOT00060047353
resolver
enst
ENSRNOT00065037779
resolver
genesymbol
Rgs7
resolver
uniprot
A0A8I5YBW3
resolver
uniprot
A0A8I6AAQ8
resolver
uniprot
A0A8I6AKV4
resolver
uniprot
Q9R0R0
resolver
uniprot_entry
A0A8I5YBW3_RAT
resolver
uniprot_entry
A0A8I6AKV4_RAT
resolver
uniprot_entry
RGS7_RAT
resolver
uniprot_sec
A0A8I6AAQ8
resolver
uniprot_sec
Q9R0R0
resolver
amino_acid_sequence
MAQGNNYGQTSNGVAEESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELHRQIKYWQIQLDRHRLKMSKVADSLLSYTEQYVEYDPFLVPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIREVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKRKGRNIPIFPCHKNCTPTLRASTNLL
uniprot
proteins
function
FUNCTION: GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades. The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form. May play a role in synaptic vesicle exocytosis (By similarity). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:10092682). {ECO:0000250|UniProtKB:O54829, ECO:0000250|UniProtKB:P49802, ECO:0000269|PubMed:10092682}.
uniprot
proteins
mass_dalton
55691
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. {ECO:0000250|UniProtKB:O46470}.; PTM: Ubiquitinated, leading to rapid proteasomal degradation. {ECO:0000250|UniProtKB:P49802}.; PTM: Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity. {ECO:0000250|UniProtKB:P49802}.
uniprot
proteins
pubmed
10092682
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8548815
uniprot
proteins
pubmed
9315921
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49802}. Cytoplasm {ECO:0000250|UniProtKB:P49802}. Cell membrane {ECO:0000250|UniProtKB:P49802}. Membrane {ECO:0000250|UniProtKB:P49802}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49802}; Cytoplasmic side {ECO:0000250|UniProtKB:P49802}. Note=Interaction with PKD1 promotes location at the cell membrane. Interaction with RGS7BP promotes location at the cell membrane. {ECO:0000250|UniProtKB:P49802}.
uniprot
proteins