Rgs14
entrez
51791
canonical
uniprot
P97492
canonical
ensembl
ENSMUSG00000052087
resolver
ensp
ENSMUSP00000068731
resolver
ensp
ENSMUSP00000318873
resolver
ensp
ENSMUSP00000318903
resolver
enst
ENSMUST00000063771
resolver
genesymbol
Rgs14
resolver
uniprot
Q8K2R4
resolver
uniprot
Q9DCD1
resolver
uniprot_entry
RGS14_MOUSE
resolver
uniprot_sec
Q8K2R4
resolver
uniprot_sec
Q9DCD1
resolver
amino_acid_sequence
MPGKPKHLGVPNGRMVLAVSDGELTSTAGSQAQGEGRGSSLSIHSLPSGPSSPFSTEEQPVASWAQSFERLLQDPRGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTKQLAQEAHNIYHEFLSSQALSPVNIDRQAWLSEEVLAQPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYQECLLAEAEGRPLREPGSSHLGSPDTARKKPKLKPGKSLPLGVEELGQLPLAEGPCGRPLRKSFRREMTGGAMNSALRRESQGSLNSSASLDLGFLAFVSSKSESHRKSLGSGESESESRPGKYCCVYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGNEQKALVLDQDCTVLADQEVRLENRITFQLELVGLERVVRISAKPTKRLQEALQPILAKHGLSLDQVVLHRPGEKQPMDLENPVSSVASQTLVLDTPPDAKMSEARSISPCRSQGCLPRTQTKDSHLPPSSSSLLVEDASSSTGNRQTCDIEGLVELLNRVQSSGAHDQRGLLRKEDLVLPEFLQLPSQRPGSREAPP
uniprot
proteins
function
FUNCTION: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3 (PubMed:29414686). May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerization and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division; required for completion of the first mitotic division of the embryo. Involved in visual memory processing capacity; when overexpressed in the V2 secondary visual cortex area. Involved in hippocampal-based learning and memory; acts as a suppressor of synaptic plasticity in CA2 neurons. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. {ECO:0000269|PubMed:10926822, ECO:0000269|PubMed:15112653, ECO:0000269|PubMed:15525537, ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:16246175, ECO:0000269|PubMed:20837545, ECO:0000269|PubMed:29414686}.
uniprot
proteins
mass_dalton
59847
uniprot
proteins
mutagenesis
MUTAGEN 92..93; /note="EN->AA: Inhibits GAP activity. Does not inhibit interaction with GNAI1 in the centrosomes. Reduces the down-regulation of G(i)-dependent signaling. Does not affect subcellular location and does not promote gene transcription activation. Inhibits strongly the down-regulation of G(i)-dependent signaling; when associated with F-519. Inhibits the interaction with GNAI1 in the centrosomes; when associated with A-518."; /evidence="ECO:0000269|PubMed:15112653, ECO:0000269|PubMed:15520006, ECO:0000269|PubMed:17635935"; MUTAGEN 261; /note="S->A: Does not affect subcellular location; when associated with A-497."; /evidence="ECO:0000269|PubMed:15520006"; MUTAGEN 336; /note="R->L: Reduces interaction with RABGEF1 and RAP2A. Strongly reduces interaction with RAP2A; when associated with L-409."; /evidence="ECO:0000269|PubMed:15112653, ECO:0000269|PubMed:15520006, ECO:0000269|PubMed:16246175"; MUTAGEN 409; /note="H->L: Does not reduce interaction with RAP2A. Strongly reduces interaction with RAP2A; when associated with L-336."; /evidence="ECO:0000269|PubMed:15520006, ECO:0000269|PubMed:16246175"; MUTAGEN 497; /note="T->A: Does not affect subcellular location; when associated with A-261."; /evidence="ECO:0000269|PubMed:15520006"; MUTAGEN 506..507; /note="LL->AA: Strongly expressed in the nucleus, mainly associated with PML nuclear bodies but not with centrosomes. Promotes gene transcription activation."; /evidence="ECO:0000269|PubMed:15520006"; MUTAGEN 518; /note="Q->A: Inhibits GDI activity. Does not inhibit interaction with GNAI1 in the centrosomes, does not affect subcellular location and does not promote gene transcription activation. Inhibits interaction with GNAI1 in the centrosomes; when associated with A-92-93-A."; /evidence="ECO:0000269|PubMed:15520006, ECO:0000269|PubMed:17635935"; MUTAGEN 519; /note="R->F: Reduces interaction with GNAI1 and GNAI2. Inhibits strongly the down-regulation of G(i)-dependent signaling; when associated with A-92-93-A."; /evidence="ECO:0000269|PubMed:15112653
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKC. Phosphorylation is increased in presence of forskolin and may enhance the GDI activity on G(i) alpha subunit GNAI1 (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
10926822
uniprot
proteins
pubmed
15112653
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15520006
uniprot
proteins
pubmed
15525537
uniprot
proteins
pubmed
15917656
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16246175
uniprot
proteins
pubmed
17635935
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20837545
uniprot
proteins
pubmed
21158412
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29414686
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body. Cytoplasm. Membrane. Cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, dendrite. Cell projection, dendritic spine. Postsynaptic density. Note=Localizes with spindle poles during metaphase. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Recruited from the cytosol to the plasma membrane by the inactive GDP-bound forms of G(i) alpha subunits GNAI1 and GNAI3. Recruited from the cytosol to membranes by the active GTP-bound form of HRAS. Colocalizes with G(i) alpha subunit GNAI1 and RIC8A at the plasma membrane. Colocalizes with BRAF and RAF1 in both the cytoplasm and membranes (By similarity). Associates with the perinuclear sheaths of microtubules (MTs) surrounding the pronuclei, prior to segregating to the anastral mitotic apparatus and subsequently the barrel- shaped cytoplasmic bridge between the nascent nuclei of the emerging 2-cell embryo. Localizes to a perinuclear compartment near the microtubule-organizing center (MTOC). Expressed in the nucleus during interphase and segregates to the centrosomes and astral MTs during mitosis. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Relocalizes to the nucleus in PML nuclear bodies in respons to heat stress. Colocalizes with RIC8A in CA2 hippocampal neurons. {ECO:0000250}.
uniprot
proteins