Tfdp1
entrez
21781
canonical
uniprot
Q08639
canonical
ensembl
ENSMUSG00000038482
resolver
ensp
ENSMUSP00000127952
resolver
ensp
ENSMUSP00000147662
resolver
ensp
ENSMUSP00000147881
resolver
ensp
ENSMUSP00000266520
resolver
ensp
ENSMUSP00000266544
resolver
enst
ENSMUST00000170909
resolver
enst
ENSMUST00000209396
resolver
enst
ENSMUST00000209885
resolver
genesymbol
Tfdp1
resolver
uniprot
A0A1B0GRU1
resolver
uniprot
Q3V3X3
resolver
uniprot
Q9CYZ7
resolver
uniprot
Q9D297
resolver
uniprot_entry
A0A1B0GRU1_MOUSE
resolver
uniprot_entry
Q3V3X3_MOUSE
resolver
uniprot_entry
Q9CYZ7_MOUSE
resolver
uniprot_entry
Q9D297_MOUSE
resolver
uniprot_entry
TFDP1_MOUSE
resolver
amino_acid_sequence
MAKDASLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNTLGKQLLPKTFGQSNVNITQQVVIGTPQRPAASNTIVVGSPHTPNTHFVSQNQTSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRQAEQQARRPPPPNSVIHLPFIIVNTSRKTVIDCSISNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGNCSAEDLKVARSLVPKALEPYVTEMAQGSIGGVFVTTTGSTSNGTRLSASDLSNGADGMLATSSNGSQYSGSRVETPVSYVGEDDDDDDDFNENDEED
uniprot
proteins
function
FUNCTION: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000250|UniProtKB:Q14186, ECO:0000269|PubMed:20176812}.
uniprot
proteins
mass_dalton
45231
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the BCR(KBTBD5) complex, leading to its subsequent degradation. {ECO:0000269|PubMed:25940086}.; PTM: Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation. {ECO:0000250|UniProtKB:Q14186}.
uniprot
proteins
protein_family
E2F/DP family
uniprot
proteins
pubmed
20176812
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25940086
uniprot
proteins
pubmed
8405995
uniprot
proteins
pubmed
8413592
uniprot
proteins
pubmed
8446173
uniprot
proteins
pubmed
9149906
uniprot
proteins
pubmed
9376316
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25940086}. Cytoplasm {ECO:0000269|PubMed:25940086}. Note=Shuttles between the cytoplasm and nucleus and translocates into the nuclear compartment upon heterodimerization with E2F1. {ECO:0000305|PubMed:25940086}.
uniprot
proteins