Map3k20
entrez
65964
canonical
uniprot
Q9ESL4
canonical
ensembl
ENSMUSG00000004085
resolver
ensp
ENSMUSP00000088334
resolver
ensp
ENSMUSP00000118983
resolver
genesymbol
Map3k20
resolver
genesymbol_syn
B230120H23Rik
resolver
genesymbol_syn
Mltk
resolver
genesymbol_syn
Zak
resolver
uniprot
Q3TRG2
resolver
uniprot
Q3V1X8
resolver
uniprot
Q8BR73
resolver
uniprot
Q9ESL3
resolver
uniprot_entry
M3K20_MOUSE
resolver
uniprot_entry
Q3TRG2_MOUSE
resolver
uniprot_sec
Q3V1X8
resolver
uniprot_sec
Q8BR73
resolver
uniprot_sec
Q9ESL3
resolver
activity_regulation
ACTIVITY REGULATION: Activated in response to stress, such as ribosomal stress, osmotic shock and ionizing radiation. Activated by phosphorylation by PKN1, followed by autophosphorylation on Thr-161 and Ser-165. {ECO:0000250|UniProtKB:Q9NYL2}.
uniprot
proteins
amino_acid_sequence
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTNLPDQCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYFWVQQLVRKGESSVEMSGYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYLNLFHFPPLIKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEVAITYIKDVTFNTSLPDAEILKMTKPPFVMEKWIVGIAEDQTVECTVTYENDVRTPKLTKHVHSIQWDRTKPQDEVKAVQLAIQTLFSSSEGNPGSRSDSSADCQWLDTLRMRQIASHTSLQRSQSNPILGSPFFPYFANQDSYAAAVRRTQTPVKYQQITPSINPSRSSSPTQYGLSRNFSSLNLSSRDSGFSSLNDSSSERGRYSDRSRNKYYRGSVSLNSSPKGRYGGKSQHSTPSRERYSGKFYRLPQSALNTHQSPDFKRSPNDHDRRVPRTIPGMPLHPETASKAGEEESRVSEGGWTKVEYRKKTHRQLSAKTSKERTRGNYRGRRNF
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:11042189, PubMed:27598200). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11042189). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (By similarity). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (By similarity). {ECO:0000250|UniProtKB:Q9NYL2, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:27598200}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR) (PubMed:32289254). Directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (By similarity). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (By similarity). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (By similarity). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (By similarity). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (By similarity). {ECO:0000250|UniProtKB:Q9NYL2, ECO:0000269|PubMed:32289254}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress. May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha. {ECO:0000250|UniProtKB:Q9NYL2}.
uniprot
proteins
mass_dalton
91720
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="K->M: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:11042189"; MUTAGEN 368; /note="F->C: Causes a split-hand/split-foot phenotype in knockin mice. Gain-of-function mutant that cases a constitutive ribotoxic stress response (RSR)."; /evidence="ECO:0000269|PubMed:32289254
uniprot
proteins
post_translational_modification
PTM: Activated by phosphorylation by PKN1, followed by autophosphorylation on Thr-161 and Ser-165 (By similarity). Autophosphorylation in response to ribotoxic stress promotes dissociation from colliding ribosomes and activation (By similarity). {ECO:0000250|UniProtKB:Q9NYL2}.
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
11042189
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26755636
uniprot
proteins
pubmed
27598200
uniprot
proteins
pubmed
32289254
uniprot
proteins
sequence_length
802
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11042189}. Nucleus {ECO:0000269|PubMed:11042189}. Note=Appears to shuttle between nucleus and cytoplasm. {ECO:0000269|PubMed:11042189}.
uniprot
proteins