Nudt5
entrez
361274
canonical
uniprot
Q6AY63
canonical
ensembl
ENSRNOG00000017741
resolver
ensembl
ENSRNOG00055017867
resolver
ensembl
ENSRNOG00060008442
resolver
ensembl
ENSRNOG00065007710
resolver
ensp
ENSRNOP00000075734
resolver
ensp
ENSRNOP00055024309
resolver
ensp
ENSRNOP00060010774
resolver
ensp
ENSRNOP00065008815
resolver
enst
ENSRNOT00000082669
resolver
enst
ENSRNOT00055030240
resolver
enst
ENSRNOT00060014075
resolver
enst
ENSRNOT00065012077
resolver
genesymbol
Nudt5
resolver
uniprot_entry
NUDT5_RAT
resolver
amino_acid_sequence
METQEPKDSSPPTEQRILSEELISEGKWVKFEKTTYMDPTGKTRTWETVKLTTRKGKSADAVSVIPVLQRTLHHECIVLVKQFRPPMGGYCLEFPAGLIEDGESPEAAALRELEEETGYKGDIAECSPAVCMDPGLSNCTTHVVTVTINGDDAGNVRPKPKPGDGEFVEVISLPKNDLLTRLDALGAEDRLTVDARVYAYALALKHANAKPFEVPFLKF
uniprot
proteins
ec_number
2.7.7.96
uniprot
proteins
ec_number
3.6.1.13
uniprot
proteins
ec_number
3.6.1.58
uniprot
proteins
function
FUNCTION: Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. In vitro, it has decapping activity on 11-mer RNA capped with uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) by hydrolyzing the pyrophosphate bridge of the sugar cap (By similarity). Does not play a role in U8 snoRNA decapping (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250|UniProtKB:Q9JKX6, ECO:0000250|UniProtKB:Q9UKK9}.
uniprot
proteins
mass_dalton
24117
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-45 is required for homodimer stability; dephosphorylation results in destabilization of the homodimer. Dephosphorylation at Thr-45 promotes the ATP-synthesis activity. {ECO:0000250|UniProtKB:Q9UKK9}.
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UKK9}.
uniprot
proteins