TPSAB1
entrez
7177
canonical
uniprot
Q15661
canonical
ensembl
ENSG00000172236
resolver
ensp
ENSP00000343577
resolver
genesymbol
TPSAB1
resolver
genesymbol_syn
TPS1
resolver
genesymbol_syn
TPS2
resolver
genesymbol_syn
TPSB1
resolver
hgnc
HGNC:12019
resolver
uniprot
D2E6R9
resolver
uniprot
D2E6S1
resolver
uniprot
P15157
resolver
uniprot
Q15663
resolver
uniprot
Q6B052
resolver
uniprot
Q9H2Y4
resolver
uniprot
Q9H2Y5
resolver
uniprot
Q9UQI1
resolver
uniprot_entry
TRYB1_HUMAN
resolver
uniprot_sec
D2E6R9
resolver
uniprot_sec
D2E6S1
resolver
uniprot_sec
P15157
resolver
uniprot_sec
Q15663
resolver
uniprot_sec
Q6B052
resolver
uniprot_sec
Q9H2Y4
resolver
uniprot_sec
Q9H2Y5
resolver
uniprot_sec
Q9UQI1
resolver
amino_acid_sequence
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
uniprot
proteins
disease_involvement
DISEASE: Note=Hereditary alpha tryptasemia is caused by an increase in the copy number (usually between two and three copies) of the alpha allele. Affected individuals have elevated basal serum tryptase levels that are associated with cutaneous flushing and pruritus, dysautonomia, functional gastrointestinal symptoms, chronic pain, and connective tissue abnormalities. It is not clear if the associated multisystem complaints might be due to the coinheritance of a second functional genetic variant. {ECO:0000269|PubMed:27749843}.
uniprot
proteins
ec_number
3.4.21.59
uniprot
proteins
function
FUNCTION: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315). {ECO:0000250, ECO:0000250|UniProtKB:P21845, ECO:0000269|PubMed:18854315}.
uniprot
proteins
mass_dalton
30515
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
protein_family
Tryptase subfamily
uniprot
proteins
pubmed
10898108
uniprot
proteins
pubmed
12162961
uniprot
proteins
pubmed
14670919
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
18039527
uniprot
proteins
pubmed
18854315
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19748655
uniprot
proteins
pubmed
2187193
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2677049
uniprot
proteins
pubmed
27749843
uniprot
proteins
pubmed
3543004
uniprot
proteins
pubmed
9920877
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted. Note=Released from the secretory granules upon mast cell activation. {ECO:0000250}.
uniprot
proteins