D7Ertd443e
entrez
71007
canonical
uniprot
D2J0Y4
canonical
ensembl
ENSMUSG00000030994
resolver
ensp
ENSMUSP00000091539
resolver
ensp
ENSMUSP00000101735
resolver
ensp
ENSMUSP00000134479
resolver
enst
ENSMUST00000094002
resolver
enst
ENSMUST00000106129
resolver
enst
ENSMUST00000172947
resolver
genesymbol
D7Ertd443e
resolver
genesymbol_syn
Fats
resolver
uniprot
A0ACM8Q217
resolver
uniprot
F7AZE7
resolver
uniprot
G3UZF7
resolver
uniprot
Q9D4E0
resolver
uniprot_entry
A0ACM8Q217_MOUSE
resolver
uniprot_entry
CJ090_MOUSE
resolver
uniprot_entry
G3UZF7_MOUSE
resolver
uniprot_entry
Q9D4E0_MOUSE
resolver
uniprot_sec
F7AZE7
resolver
amino_acid_sequence
MISPVVISRLIDEKKSMENGAILPQAIAQPQLCPTKPALARRDGVSMHRRFALSPDRLGILTPSDDQGLETEPLSTGDNLGKGSHSGFSSITITARRVGPPASSLVWDTFRDPLCPKCKAKDALFQEPPVLAGDAHLCQHNRPFTCTESPSNGSVEGMKVFQAHSRLSARQDYWVTHTNDNEDSFSSDNSPSRKVPLVFSSCVHFRVSQQCPNAIYYLDKSLSVPLERPQIASPKMHRSVLSLSLRCSSHQLTADGVDSSANGEPISTALSQELSEGKQDLLGPQWGQPQGGHWKESPALVPVHLGSGTCPRTGSPPLENVKFADVGRNQVPVRKEKEDHATCTSSSHTNQLSIHIPGWSYRAETKVLSGSKKQQQEAQRTLPAFPVGQKTIKHFPPEGDSSPSSDGQPSILSESNERQHPYFMIPRVPLPGFYCPLQTGCASLQEDGAVQIETHFPKDYTCCDLVVKLKECEKNEDPTVTPEPSPATPSPSTPEGAQSSDPSEDSYEPLLASSMTLQEALEVHRPQFISRSQERLQKLKRMVQQRKTQQKESLGQKQSLLPVRANKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYNNLPEVKKKKEEQKKRMILQSNRLRAEVFKKQLLDQLLQRNAV
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
function
FUNCTION: Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage (PubMed:20154723, PubMed:20843368, PubMed:24240685). Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response (PubMed:24240685). Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (PubMed:20154723). May have a role in the assembly of primary cilia (By similarity). {ECO:0000250|UniProtKB:Q96M02, ECO:0000269|PubMed:20154723, ECO:0000269|PubMed:20843368, ECO:0000269|PubMed:24240685}.
uniprot
proteins
mass_dalton
71521
uniprot
proteins
mutagenesis
MUTAGEN 118; /note="C->G: No effect on p53/TP53 polyubiquitination."; /evidence="ECO:0000269|PubMed:24240685"; MUTAGEN 202; /note="C->G: No effect on p53/TP53 polyubiquitination."; /evidence="ECO:0000269|PubMed:24240685"; MUTAGEN 211; /note="C->G: Abolishes p53/TP53 polyubiquitination. No effect on interaction with p53/TP53."; /evidence="ECO:0000269|PubMed:24240685"; MUTAGEN 247; /note="C->G: No effect on p53/TP53 polyubiquitination."; /evidence="ECO:0000269|PubMed:24240685
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20154723
uniprot
proteins
pubmed
20843368
uniprot
proteins
pubmed
24240685
uniprot
proteins
sequence_length
644
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96M02}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q96M02}. Note=Localizes to the actin cytoskeleton in a proportion of cells. Colocalizes with centriolar acetylated tubulin (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q96M02}.
uniprot
proteins