Rpap2
entrez
231571
canonical
uniprot
Q8VC34
canonical
ensembl
ENSMUSG00000033773
resolver
ensp
ENSMUSP00000070209
resolver
ensp
ENSMUSP00000108269
resolver
ensp
ENSMUSP00000108270
resolver
ensp
ENSMUSP00000108273
resolver
ensp
ENSMUSP00000108274
resolver
genesymbol
Rpap2
resolver
uniprot
Q3TLC8
resolver
uniprot
Q3TSP8
resolver
uniprot
Q3UKX0
resolver
uniprot
Q8C7M5
resolver
uniprot
Q8CBW8
resolver
uniprot_entry
RPAP2_MOUSE
resolver
uniprot_sec
Q3TLC8
resolver
uniprot_sec
Q3TSP8
resolver
uniprot_sec
Q3UKX0
resolver
uniprot_sec
Q8C7M5
resolver
uniprot_sec
Q8CBW8
resolver
amino_acid_sequence
MADSAVPCSLGPSTRASSTHRDATGTKQTRALKRGDASKRQAELEAAIQRKVEFERKAVRIVEQLLEENITEEFLKECGMFITPAHYSDVVDERSIIKLCGYPLCQKKLGVIPKQKYRISTKTNKVYDITERKSFCSNFCYRASKFFETQIPKTPVWVREEERPPDFQLLKKGQSGSSGEVVQFFRDAVTAADVDGSGALEAQCDPASSSSWSERASDEEEQGFVSSLLPGNRPKAVDTRPQPHTKSSIMRKKAAQNVDSKEGEQTVSEVTEQLDNCRLDSQEKVATCKRPLKKESTQISSPGPLCDRFNTSAISEHKHGVSQVTLVGISKKSAEHFRSKFAKSNPGSGSASGLVHVRPEVAKANLLRVLSDTLTEWKTEETLKFLYGQNHDSVCLKPSSASEPDEELDEDDISCDPGSCGPALSQAQNTLDATLPFRGSDTAIKPLPSYESLKKETEMLNLRVREFYRGRCVLNEDTTKSQDSKESVLQRDPSFPLIDSSSQNQIRRRIVLEKLSKVLPGLLGPLQITMGDIYTELKNLIQTFRLSNRNIIHKPVEWTLIAVVLLLLLTPILGIQKHSPKNVVFTQFIATLLTELHLKFEDLEKLTMIFRTSC
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:35975910). {ECO:0000250|UniProtKB:Q8IXW5, ECO:0000269|PubMed:35975910}.
uniprot
proteins
mass_dalton
68530
uniprot
proteins
protein_family
RPAP2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
35975910
uniprot
proteins
sequence_length
614
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner. {ECO:0000250}.
uniprot
proteins