Sgms1
entrez
353229
canonical
uniprot
Q7TSX5
canonical
ensembl
ENSRNOG00000012536
resolver
ensembl
ENSRNOG00055029549
resolver
ensembl
ENSRNOG00060029314
resolver
ensembl
ENSRNOG00065029362
resolver
ensp
ENSRNOP00000051643
resolver
ensp
ENSRNOP00055042182
resolver
ensp
ENSRNOP00060042352
resolver
ensp
ENSRNOP00065041696
resolver
enst
ENSRNOT00000054761
resolver
enst
ENSRNOT00055051208
resolver
enst
ENSRNOT00060050912
resolver
enst
ENSRNOT00065050729
resolver
genesymbol
Sgms1
resolver
genesymbol_syn
Mob
resolver
genesymbol_syn
Tmem23
resolver
uniprot_entry
SMS1_RAT
resolver
amino_acid_sequence
MLSASTMKEVVYWSPKKVADWLLENAMPEYCEPLGHFTGQDLINLTQEDFTKPPLCRVSSDNGQRLLDMIETLKMEHHIEAHKNGHANGHLSIGVDIPNPDGSFSIKIKPNGMPNGFRKEMIKIPMPEPERSQYPMEWGKTLLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLFQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQVRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPLPWPVVHLSRQVKYSRLVNDT
uniprot
proteins
ec_number
2.7.8.27
uniprot
proteins
function
FUNCTION: Major sphingomyelin synthase at the Golgi apparatus. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes. Converts the newly synthesized CER, that is transported from the endoplasmic reticulum to the trans-Golgi by the Cer transport protein (CERT), to SM. Can form a heteromeric complex with glucosylceramide synthase (GCS) increasing SMS activity and reducing glucosylceramide synthesis, a critical mechanism that controls the metabolic fate of CER in the Golgi (By similarity). Does not use free phosphorylcholine or CDP-choline as donor. Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to CER to form ceramide phosphoethanolamine (CPE) (By similarity). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting. Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (PubMed:21980337). {ECO:0000250|UniProtKB:Q86VZ5, ECO:0000250|UniProtKB:Q8VCQ6, ECO:0000269|PubMed:21980337}.
uniprot
proteins
mass_dalton
49014
uniprot
proteins
pathway_participation
PATHWAY: Sphingolipid metabolism. {ECO:0000250|UniProtKB:Q86VZ5}.
uniprot
proteins
protein_family
Sphingomyelin synthase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21980337
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q86VZ5}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 221..241; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 282..302; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 310..330; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 336..353; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins