Il13
entrez
116553
canonical
uniprot
P42203
canonical
ensembl
ENSRNOG00000007652
resolver
ensembl
ENSRNOG00055029966
resolver
ensembl
ENSRNOG00060022076
resolver
ensembl
ENSRNOG00065005588
resolver
ensp
ENSRNOP00000010121
resolver
ensp
ENSRNOP00055042873
resolver
ensp
ENSRNOP00060031517
resolver
ensp
ENSRNOP00065005823
resolver
enst
ENSRNOT00000010121
resolver
enst
ENSRNOT00055051937
resolver
enst
ENSRNOT00060038236
resolver
enst
ENSRNOT00065008295
resolver
genesymbol
Il13
resolver
genesymbol_syn
Il-13
resolver
uniprot_entry
IL13_RAT
resolver
amino_acid_sequence
MALWVTAVLALACLGGLATPGPVRRSTSPPVALRELIEELSNITQDQKTSLCNSSMVWSVDLTAGGFCAALESLTNISSCNAIHRTQRILNGLCNQKASDVASSPPDTKIEVAQFISKLLNYSKQLFRYGH
uniprot
proteins
function
FUNCTION: Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:9366558). Synergizes with IL2 in regulating interferon-gamma synthesis. Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (By similarity). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and down-regulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF through a mechanism that partially involves suppression of NF-kappa-B (PubMed:9366558). Also functions on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils. Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6. Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (By similarity). Induces inflammatory response in esophageal epithelium which results in a dysregulation of desmosome intercellular adhesion junctions, via down-regulation of DSG1 (By similarity). {ECO:0000250|UniProtKB:P20109, ECO:0000250|UniProtKB:P35225, ECO:0000269|PubMed:9366558}.
uniprot
proteins
mass_dalton
14093
uniprot
proteins
protein_family
IL-4/IL-13 family
uniprot
proteins
pubmed
7916615
uniprot
proteins
pubmed
9366558
uniprot
proteins
sequence_length
131
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins