Slc25a35
entrez
71998
canonical
uniprot
Q5SWT3
canonical
ensembl
ENSMUSG00000018740
resolver
ensp
ENSMUSP00000099666
resolver
ensp
ENSMUSP00000296847
resolver
enst
ENSMUST00000102606
resolver
genesymbol
Slc25a35
resolver
uniprot
Q3TBP2
resolver
uniprot
Q99KM5
resolver
uniprot
Q9D913
resolver
uniprot_entry
S2535_MOUSE
resolver
uniprot_sec
Q3TBP2
resolver
uniprot_sec
Q99KM5
resolver
uniprot_sec
Q9D913
resolver
activity_regulation
ACTIVITY REGULATION: Phosphoenolpyruvate transport is up-regulated at acidic pH. {ECO:0000269|PubMed:41850288}.
uniprot
proteins
amino_acid_sequence
MDFLMSGVAACGACVFTNPLEVVKTRMQLQGELQAPGTYQRHYRNVFHAFFTIGKVDGLAALQKGLGPALLYQFLMNGIRLGTYGLAESRGYLHTNEGTHSPVRSAAAGALAGVMGAYLGSPIYMVKTHLQAQAASEIAVGHQYKHQGMFQALTEIGQKHGLVGLWRGAVGGLPRVVIGSSTQLCTFSSIKDLLSQWEIFPPQSWKVALAAAMVSGVAIVVAMTPFDVASTRLYNQPTDTRGKGLMYRGILDALLQTARTEGFFGMYKGIGASYFRLGPHTILSLFFWDQLRSFYNTYAK
uniprot
proteins
function
FUNCTION: Mediates phosphoenolpyruvate (PEP) efflux across the inner membrane of mitochondria as part of glyceroneogenesis pathway in the liver and adipose tissue. Transports PEP generated via the mitochondrial PC- and PCK2-dependent pyruvate-to-PEP bypass, thereby driving PEP flux required for cytosolic glycerol 3-phosphate and triglyceride synthesis. Controls INS-induced glycerolipid synthesis in adipocytes (PubMed:41850288). Most likely operates as an antiporter that exchanges monocarboxylates such as PEP and possibly dicarboxylates and sulfur oxoanions across the inner membrane of mitochondria. PEP transport is gated by mitochondrial membrane potential, although the precise transport mechanism has yet to be fully elucidated (By similarity) (PubMed:41850288). {ECO:0000250|UniProtKB:Q3KQZ1, ECO:0000269|PubMed:41850288}.
uniprot
proteins
mass_dalton
32631
uniprot
proteins
mutagenesis
MUTAGEN 124; /note="Y->A: Has no effect on phosphoenolpyruvate transport. Increases phosphoenolpyruvate transport; when associated with A-175 and A-276."; /evidence="ECO:0000269|PubMed:41850288"; MUTAGEN 175; /note="R->A: Has no effect on phosphoenolpyruvate transport. Increases phosphoenolpyruvate transport; when associated with A-124 and A-276."; /evidence="ECO:0000269|PubMed:41850288"; MUTAGEN 276; /note="R->A: Increases phosphoenolpyruvate transport; when associated with A-124 and A-175."; /evidence="ECO:0000269|PubMed:41850288
uniprot
proteins
pathway_participation
PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis. {ECO:0000269|PubMed:41850288}.
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
41850288
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:41850288}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 59..79; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 91..119; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 169..190; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 205..225; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 277..300; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins