Fis1
entrez
66437
canonical
uniprot
Q9CQ92
canonical
ensembl
ENSMUSG00000019054
resolver
ensp
ENSMUSP00000019198
resolver
ensp
ENSMUSP00000106723
resolver
ensp
ENSMUSP00000106726
resolver
enst
ENSMUST00000019198
resolver
enst
ENSMUST00000111094
resolver
enst
ENSMUST00000111097
resolver
genesymbol
Fis1
resolver
genesymbol_syn
Ttc11
resolver
uniprot
D3YZ32
resolver
uniprot
G3X9U9
resolver
uniprot_entry
D3YZ32_MOUSE
resolver
uniprot_entry
FIS1_MOUSE
resolver
uniprot_entry
G3X9U9_MOUSE
resolver
amino_acid_sequence
MEAVLNELVSVEDLKNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNEDIRRGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS
uniprot
proteins
function
FUNCTION: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:23283981). Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (PubMed:23283981). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (By similarity). Also mediates peroxisomal fission (By similarity). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (By similarity). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (By similarity). {ECO:0000250|UniProtKB:Q9Y3D6, ECO:0000269|PubMed:23283981}.
uniprot
proteins
mass_dalton
17009
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MARCHF5. {ECO:0000250|UniProtKB:Q9Y3D6}.
uniprot
proteins
protein_family
FIS1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23283981
uniprot
proteins
sequence_length
152
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9Y3D6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9Y3D6}. Peroxisome membrane {ECO:0000250|UniProtKB:Q9Y3D6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9Y3D6}.
uniprot
proteins
transmembrane_region
TRANSMEM 123..143; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins