Q9R283
uniprot
Q9R283
canonical
amino_acid_sequence
MLMSLTDSKEGKNRSGVRMFKDDDFLIPASGESWDRLRLTCSQPFTRHQSFGLAFLRVRSSLDSLSDPVKDPSSPGSSGLNQNSSDKLESDPSPWLTNPSIRRTFFPDPQTSTKEISALKGMLKQLQPGPLGRAARMVLSAAHKAPPASVVSPNNSHGEPDSSHPERAEPRAEEPNRKNNASRGKRRKVQEQRRPLSSSSSQPNRRATGRTKQRQQRPQAKSDGSGVQATGQCPICTGSFSIEALPRHAATCGESSPPQPASPTSLSSSESVLRCLHVALTPVPLIPKPNWTEIVNKKLKFPPTLLRAIQEGQLGLVQQLLESGSDPSGAGPGGPLRNVEESEDRSWREALNLAIRLGHEVITDVLLANVKFDFRQIHEALLVAVDTNQPAVVRRLLARLEREKGRKVDTKSFSLAFFDSSIDGSRFAPGVTPLTLACQKDLYEIAQLLMDQGHTIARPHPVSCACLECSNARRYDLLKFSLSRINTYRGIASRAHLSLASEDAMLAAFQLSRELRRLARKEPEFKPQYIALESLCQDYGFELLGMCRNQSEVTAVLNDLGEDSETEPEAEGLGQAFEEGIPNLARLRLAVNYNQKQFVAHPICQQVLSSIWCGNLAGWRGSTTIWKLFVAFLIFLTMPFLCIGYWLAPKSRLGRLLKIPVLKFLLHSASYLWFLIFLLGESLVMETQLSTFKGRSQSVWETSLHMIWVTGFLWFECKEVWIEGLRSYLLDWWNFLDVVILSLYLASFALRLLLAGLAYMHCRDASDSSTCRYFTTAERSEWRTEDPQFLAEVLFAVTSMLSFTRLAYILPAHESLGTLQISIGKMIDDMIRFMFILMIILTAFLCGLNNIYVPYQETEKLGNFNETFQFLFWTMFGMEEHSVVDMPQFLVPEFVGRAMYGIFTIVMVIVLLNMLIAMITNSFQKIEDDADVEWKFARSKLYLSYFREGLTLPVPFNILPSPKAAFYLLRRIFRFICCGSSCCKAKKSDYPPIPTFTNPGARAGPGEGEHVSYRLRVIKALVQRYIETARREFEETRRKDLGNRLTELTKTVSRLQSEVASVQKTVAAGGALRPPDGASILSRYITRVRNSFQNLGPPAPDTPAELTMPGIVETEVSLEDSLDATGEAGTPASGESSSSSSAHVLVHREQEAEGAGDLPLGEDLETKGES
uniprot
proteins
function
FUNCTION: Forms a Ca(2+)-permeable non-selective cation channel that mediates Ca(2+) influx upon activation. In vomeronasal sensory neurons, functions as the principal transduction channel gated by diacylglycerol (DAG) downstream of phospholipase C-coupled receptors. Required for conditioned place aversion to hypoxic environments. In main olfactory epithelium type B cells, operates downstream of the soluble guanylate cyclase Gucy1b2 and cGMP-dependent protein kinase to mediate Ca(2+) entry in response to low environmental oxygen. Also plays roles in erythropoietin-stimulated Ca(2+) influx in erythroid cells and the sperm acrosome reaction. Required for pheromone-evoked social and reproductive behaviors including sex discrimination, male-male aggression, female sexual receptivity (Esp1-dependent), and inhibition of adult male mating behavior toward juveniles (Esp22-dependent). {ECO:0000250|UniProtKB:Q9R244}.
uniprot
proteins
mass_dalton
130467
uniprot
proteins
protein_family
STrpC subfamily
uniprot
proteins
protein_family
TRPC2 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
10318963
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
1170
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9R244}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 628..648; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 659..679; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 702..722; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 738..758; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 789..809; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 833..853; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 899..919; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins