IL17RC
entrez
84818
canonical
uniprot
Q8NAC3
canonical
ensembl
ENSG00000163702
resolver
ensp
ENSP00000295981
resolver
ensp
ENSP00000373323
resolver
ensp
ENSP00000384969
resolver
ensp
ENSP00000395315
resolver
ensp
ENSP00000396064
resolver
ensp
ENSP00000407894
resolver
ensp
ENSP00000414609
resolver
ensp
ENSP00000512897
resolver
ensp
ENSP00000512902
resolver
ensp
ENSP00000512904
resolver
ensp
ENSP00000540003
resolver
ensp
ENSP00000540005
resolver
ensp
ENSP00000540006
resolver
ensp
ENSP00000540007
resolver
ensp
ENSP00000540008
resolver
ensp
ENSP00000540009
resolver
ensp
ENSP00000540010
resolver
ensp
ENSP00000540011
resolver
ensp
ENSP00000540012
resolver
ensp
ENSP00000540014
resolver
ensp
ENSP00000540015
resolver
ensp
ENSP00000540017
resolver
ensp
ENSP00000540018
resolver
ensp
ENSP00000540019
resolver
ensp
ENSP00000540024
resolver
ensp
ENSP00000540027
resolver
ensp
ENSP00000540040
resolver
ensp
ENSP00000540056
resolver
ensp
ENSP00000540061
resolver
ensp
ENSP00000540068
resolver
ensp
ENSP00000540087
resolver
ensp
ENSP00000642593
resolver
enst
ENST00000438091
resolver
enst
ENST00000696824
resolver
enst
ENST00000696826
resolver
genesymbol
IL17RC
resolver
hgnc
HGNC:18358
resolver
uniprot
A0A8Q3SIV5
resolver
uniprot
A0A8Q3SJ01
resolver
uniprot
A8BWC1
resolver
uniprot
A8BWC9
resolver
uniprot
A8BWD5
resolver
uniprot
C9JSZ3
resolver
uniprot
E9PHG1
resolver
uniprot
E9PHJ6
resolver
uniprot
Q6UVY3
resolver
uniprot
Q6UWD4
resolver
uniprot
Q8NFS1
resolver
uniprot
Q9BR97
resolver
uniprot_entry
A0A8Q3SIV5_HUMAN
resolver
uniprot_entry
A0A8Q3SJ01_HUMAN
resolver
uniprot_entry
C9JSZ3_HUMAN
resolver
uniprot_entry
I17RC_HUMAN
resolver
uniprot_sec
A8BWC1
resolver
uniprot_sec
A8BWC9
resolver
uniprot_sec
A8BWD5
resolver
uniprot_sec
E9PHG1
resolver
uniprot_sec
E9PHJ6
resolver
uniprot_sec
Q6UVY3
resolver
uniprot_sec
Q6UWD4
resolver
uniprot_sec
Q8NFS1
resolver
uniprot_sec
Q9BR97
resolver
amino_acid_sequence
MPVPWFLLSLALGRSPVVLSLERLVGPQDATHCSPVSLEPWGDEERLRVQFLAQQSLSLAPVTAATARTALSGLSGADGRREERGRGKSWVCLSLGGSGNTEPQKKGLSCRLWDSDILCLPGDIVPAPGPVLAPTHLQTELVLRCQKETDCDLCLRVAVHLAVHGHWEEPEDEEKFGGAADSGVEEPRNASLQAQVVLSFQAYPTARCVLLEVQVPAALVQFGQSVGSVVYDCFEAALGSEVRIWSYTQPRYEKELNHTQQLPDCRGLEVWNSIPSCWALPWLNVSADGDNVHLVLNVSEEQHFGLSLYWNQVQGPPKPRWHKNLTGPQIITLNHTDLVPCLCIQVWPLEPDSVRTNICPFREDPRAHQNLWQAARLQLLTLQSWLLDAPCSLPAEAALCWRAPGGDPCQPLVPPLSWENVTVDKVLEFPLLKGHPNLCVQVNSSEKLQLQECLWADSLGPLKDDVLLLETRGPQDNRSLCALEPSGCTSLPSKASTRAARLGEYLLQDLQSGQCLQLWDDDLGALWACPMDKYIHKRWALVWLACLLFAAALSLILLLKKDHAKGWLRLLKQDVRSGAAARGRAALLLYSADDSGFERLVGALASALCQLPLRVAVDLWSRRELSAQGPVAWFHAQRRQTLQEGGVVVLLFSPGAVALCSEWLQDGVSGPGAHGPHDAFRASLSCVLPDFLQGRAPGSYVGACFDRLLHPDAVPALFRTVPVFTLPSQLPDFLGALQQPRAPRSGRLQERAEQVSRALQPALDSYFHPPGTPAPGRGVGPGAGPGAGDGT
uniprot
proteins
disease_involvement
DISEASE: Candidiasis, familial, 9 (CANDF9) [MIM:616445]: A disorder characterized by altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269|PubMed:25918342}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (By similarity). Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:16785495, PubMed:32187518). Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (By similarity). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:17911633, PubMed:18684971). Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). {ECO:0000250|UniProtKB:Q8K4C2, ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:32187518}.; FUNCTION: [Isoform 5]: Receptor for both IL17A and IL17F. {ECO:0000269|PubMed:16785495}.; FUNCTION: [Isoform 6]: Does not bind IL17A or IL17F. {ECO:0000269|PubMed:16785495}.; FUNCTION: [Isoform 7]: Does not bind IL17A or IL17F. {ECO:0000269|PubMed:16785495}.; FUNCTION: [Isoform 8]: Receptor for both IL17A and IL17F. {ECO:0000269|PubMed:16785495}.
uniprot
proteins
mass_dalton
86240
uniprot
proteins
pubmed
11706037
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14504135
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16785495
uniprot
proteins
pubmed
17911633
uniprot
proteins
pubmed
18684971
uniprot
proteins
pubmed
24120361
uniprot
proteins
pubmed
25918342
uniprot
proteins
pubmed
28827714
uniprot
proteins
pubmed
32187518
uniprot
proteins
sequence_length
791
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17911633}; Single-pass type I membrane protein {ECO:0000255}. Note=Soluble isoforms may be produced.
uniprot
proteins
transmembrane_region
TRANSMEM 539..559; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins