Shank3
entrez
58234
canonical
uniprot
Q4ACU6
canonical
ensembl
ENSMUSG00000022623
resolver
ensp
ENSMUSP00000104932
resolver
genesymbol
Shank3
resolver
genesymbol_syn
Kiaa1650
resolver
genesymbol_syn
Prosap2
resolver
uniprot
F8S0X0
resolver
uniprot
F8S0X2
resolver
uniprot
F8S0X3
resolver
uniprot
F8S0X5
resolver
uniprot
F8S0X6
resolver
uniprot
Q69ZD8
resolver
uniprot
Q9JJZ3
resolver
uniprot
S6BMD3
resolver
uniprot
S6CCV8
resolver
uniprot_entry
SHAN3_MOUSE
resolver
uniprot_sec
F8S0X0
resolver
uniprot_sec
F8S0X2
resolver
uniprot_sec
F8S0X3
resolver
uniprot_sec
F8S0X5
resolver
uniprot_sec
F8S0X6
resolver
uniprot_sec
Q69ZD8
resolver
uniprot_sec
Q9JJZ3
resolver
uniprot_sec
S6BMD3
resolver
uniprot_sec
S6CCV8
resolver
amino_acid_sequence
MDGPGASAVVVRVGIPDLQQTKCLRLDPTAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQDYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLRNGGAHLDFRTRDGLTAVHCATRQRNAGALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGTTDENGWQEIHQACRFGHVQHLEHLLFYGANMGAQNASGNTALHICALYNQESCARVLLFRGANKDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAGPSGLASPRPLQRSASDINLKGDQPAASPGPTLRSLPHQLLLQRLQEEKDRDRDGELENDISGPSAGRGGHNKISPSGPGGSGPAPGPGPASPAPPAPPPRGPKRKLYSAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVLSIGEGGFWEGTVKGRTGWFPADCVEEVQMRQYDTRHETREDRTKRLFRHYTVGSYDSLTSHSDYVIDDKVAILQKRDHEGFGFVLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVGLIRQGGNRLVMKVVSVTRKPEEDGARRRAPPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEILAVAAEPTLRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLPGPEKLPGSLRKGIPRTKSVGEDEKLASLLEGRFPRSTSMQDTVREGRGIPPPPQTAPPPPPAPYYFDSGPPPTFSPPPPPGRAYDTVRSSFKPGLEARLGAGAAGLYDPSTPLGPLPYPERQKRARSMIILQDSAPEVGDVPRPAPAATPPERPKRRPRPSGPDSPYANLGAFSASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGPVGGSFAREPSPTHRGPRPGSLDYSSGEGLGLTFGGPSPGPVKERRLEERRRSTVFLSVGAIEGSPPSADLPSLQPSRSIDERLLGTGATTGRDLLLPSPVSALKPLVGGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQTPSRSPTPVHSPDADRPGPLFVDVQTRDSERGPLASPAFSPRSPAWIPVPARREAEKPPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRLGAEEERPGTPELAPAPMQAAAVAEPMPSPRAQPPGSIPADPGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREELARIGLVPPPEEFANGILLTTPPPGPGPLPTTVPSPASGKPSSELPPAPESAADSGVEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGKGPVTFRDPLLKQSSDSELMAQQHHAASTGLASAAGPARPRYLFQRRSKLWGDPVESRGLPGPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAARLFSSLGELSTISAQRSPGGPGGGASYSVRPSGRYPVARRAPSPVKPASLERVEGLGAGVGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSPLPSPSPGSGPSAGPRRPFQQKPLQLWSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKEDFVELGVTRVGHRMNIERALRQLDGS
uniprot
proteins
function
FUNCTION: Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:21423165, ECO:0000269|PubMed:21558424, ECO:0000269|PubMed:23739967, ECO:0000269|PubMed:24153177}.
uniprot
proteins
mass_dalton
185397
uniprot
proteins
protein_family
SHANK family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
16606358
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20613842
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21423165
uniprot
proteins
pubmed
21558424
uniprot
proteins
pubmed
22699619
uniprot
proteins
pubmed
23739967
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24153177
uniprot
proteins
pubmed
24164323
uniprot
proteins
pubmed
24259569
uniprot
proteins
pubmed
31600191
uniprot
proteins
pubmed
38233523
uniprot
proteins
sequence_length
1730
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Synapse. Postsynaptic density. Cell projection, dendritic spine {ECO:0000250}. Note=In neuronal cells, extends into the region subjacent to the postsynaptic density (PSD).
uniprot
proteins