CD8A
entrez
925
canonical
uniprot
P01732
canonical
ensembl
ENSG00000153563
resolver
ensp
ENSP00000283635
resolver
ensp
ENSP00000321631
resolver
ensp
ENSP00000386559
resolver
genesymbol
CD8A
resolver
genesymbol_syn
MAL
resolver
hgnc
HGNC:1706
resolver
uniprot
B4DT80
resolver
uniprot
D6W5M8
resolver
uniprot
Q13970
resolver
uniprot
Q4ZG17
resolver
uniprot
Q6ZVS2
resolver
uniprot
Q8TAW8
resolver
uniprot_entry
CD8A_HUMAN
resolver
uniprot_entry
Q6ZVS2_HUMAN
resolver
uniprot_entry
Q8TAW8_HUMAN
resolver
uniprot_sec
B4DT80
resolver
uniprot_sec
D6W5M8
resolver
uniprot_sec
Q13970
resolver
uniprot_sec
Q4ZG17
resolver
amino_acid_sequence
MALPVTALLLPLALLLHAARPSQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSWLFQPRGAAASPTFLLYLSQNKPKAAEGLDTQRFSGKRLGDTFVLTLSDFRRENEGYYFCSALSNSIMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHRNRRRVCKCPRPVVKSGDKPSLSARYV
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 116 (IMD116) [MIM:608957]: An autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. {ECO:0000269|PubMed:11435463, ECO:0000269|PubMed:17658607}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. {ECO:0000269|PubMed:16236125, ECO:0000269|PubMed:17678538, ECO:0000269|PubMed:23657257, ECO:0000269|PubMed:26082771}.
uniprot
proteins
mass_dalton
25729
uniprot
proteins
mutagenesis
MUTAGEN 111; /note="G->R: Prevents CD8 expression."; /evidence="ECO:0000269|PubMed:11435463"; MUTAGEN 206; /note="C->A: Complete loss of palmitoylation."; /evidence="ECO:0000269|PubMed:17341584
uniprot
proteins
post_translational_modification
PTM: Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts. {ECO:0000269|PubMed:17341584}.; PTM: O-glycosylated. {ECO:0000269|PubMed:1460019}.; PTM: Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation. {ECO:0000269|PubMed:2512251}.
uniprot
proteins
pubmed
11435463
uniprot
proteins
pubmed
12853576
uniprot
proteins
pubmed
14500983
uniprot
proteins
pubmed
1460019
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1547508
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16236125
uniprot
proteins
pubmed
17341584
uniprot
proteins
pubmed
17658607
uniprot
proteins
pubmed
17678538
uniprot
proteins
pubmed
23657257
uniprot
proteins
pubmed
2496167
uniprot
proteins
pubmed
2509342
uniprot
proteins
pubmed
2512251
uniprot
proteins
pubmed
2536941
uniprot
proteins
pubmed
26082771
uniprot
proteins
pubmed
2784196
uniprot
proteins
pubmed
3871356
uniprot
proteins
pubmed
3918796
uniprot
proteins
pubmed
3936473
uniprot
proteins
pubmed
6605969
uniprot
proteins
pubmed
7923932
uniprot
proteins
pubmed
9177355
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:1460019, ECO:0000269|PubMed:17341584, ECO:0000269|PubMed:17678538}; Single-pass type I membrane protein. Note=CD8A localizes to lipid rafts only when associated with its partner CD8B. {ECO:0000269|PubMed:17341584}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:7923932}.
uniprot
proteins
transmembrane_region
TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins