Slc6a14
entrez
56774
canonical
uniprot
Q9JMA9
canonical
ensembl
ENSMUSG00000031089
resolver
ensp
ENSMUSP00000033414
resolver
enst
ENSMUST00000033414
resolver
genesymbol
Slc6a14
resolver
uniprot
A1L359
resolver
uniprot
Q91Y60
resolver
uniprot
Q9D317
resolver
uniprot
Q9R183
resolver
uniprot_entry
A1L359_MOUSE
resolver
uniprot_entry
S6A14_MOUSE
resolver
uniprot_sec
Q91Y60
resolver
uniprot_sec
Q9D317
resolver
uniprot_sec
Q9R183
resolver
amino_acid_sequence
MDRLKCPNFFKCRQKEKVTASSENFHVGENDENQERGNWSKKSDYLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGITMVLISVFVAIYYNVIIAYSLYYLFASFQSVLPWANCSSWADENCSRTPIVTGCNVSIGAGEMFMNISWVNTNNLTCLNGSEVFRPGQLPSEQYWDKVTLQRSSGMDETGVVVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLIRGATLEGASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSSYNKFNNNCYSDAIIVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPAGPFWSILFFFMLLTLGLDSQFASIETITTTFQDLFPKAMKRMRVPITLGCCLILFLLGLLCVTQAGIYWVHLIDHFCAGWGILIAAILEIAGIIWIYGGNRFIEDIEMMIGAKRWIFWLWWRACWFVITPILLSAILVWSLVKFHRPDYADIPYPDWGVALGWCMIIFCIIWIPIMAIIKIVQAEGNILQRIISCCRPASNWGPYLEKHRGERYRDMAEPAKETDHEIPTISGSTKPE
uniprot
proteins
function
FUNCTION: Amino acid transporter that plays an important role in the absorption of amino acids in the intestinal tract. Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner (PubMed:11306607, PubMed:11447016). Transports non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (By similarity). Can also transport carnitine, butyrylcarnitine and propionylcarnitine coupled to the transmembrane gradients of Na(+) and Cl(-) (PubMed:11306651). {ECO:0000250|UniProtKB:Q9UN76, ECO:0000269|PubMed:11306607, ECO:0000269|PubMed:11306651, ECO:0000269|PubMed:11447016}.
uniprot
proteins
mass_dalton
71456
uniprot
proteins
protein_family
SLC6A14 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
11306607
uniprot
proteins
pubmed
11306651
uniprot
proteins
pubmed
11447016
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
638
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:11306651}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:11447016}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..65; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 72..92; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 231..251; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 257..277; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 395..415; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 453..473; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 476..496; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 524..544; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 559..579; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins