Glo1
entrez
109801
canonical
uniprot
Q9CPU0
canonical
ensembl
ENSMUSG00000024026
resolver
ensp
ENSMUSP00000126586
resolver
ensp
ENSMUSP00000157858
resolver
ensp
ENSMUSP00000158296
resolver
enst
ENSMUST00000167624
resolver
enst
ENSMUST00000235547
resolver
enst
ENSMUST00000236335
resolver
genesymbol
Glo1
resolver
uniprot
A5GZX3
resolver
uniprot
Q543L3
resolver
uniprot
Q8R3T1
resolver
uniprot_entry
A5GZX3_MOUSE
resolver
uniprot_entry
LGUL_MOUSE
resolver
uniprot_sec
Q543L3
resolver
uniprot_sec
Q8R3T1
resolver
activity_regulation
ACTIVITY REGULATION: Subject to competitive inhibition by methyl-gerfelin. {ECO:0000269|PubMed:18695250}.
uniprot
proteins
amino_acid_sequence
MAEPQPASSGLTDETAFSCCSDPDPSTKDFLLQQTMLRIKDPKKSLDFYTRVLGLTLLQKLDFPAMKFSLYFLAYEDKNDIPKDKSEKTAWTFSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKIATII
uniprot
proteins
ec_number
4.4.1.5
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:18695250). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). Required for normal osteoclastogenesis (PubMed:18695250). {ECO:0000250|UniProtKB:Q04760, ECO:0000269|PubMed:18695250}.
uniprot
proteins
mass_dalton
20810
uniprot
proteins
pathway_participation
PATHWAY: Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.
uniprot
proteins
post_translational_modification
PTM: Glutathionylation at Cys-139 inhibits enzyme activity. {ECO:0000250|UniProtKB:Q04760}.; PTM: Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the TNF-induced transcriptional activity of NF-kappa-B (By similarity). {ECO:0000250|UniProtKB:Q04760}.; PTM: Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses the TNF-induced transcriptional activity of NF-kappa-B (By similarity). {ECO:0000250|UniProtKB:Q04760}.
uniprot
proteins
protein_family
Glyoxalase I family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15858064
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18695250
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
184
uniprot
proteins