Arl6ip1
entrez
54208
canonical
uniprot
Q9JKW0
canonical
ensembl
ENSMUSG00000030654
resolver
ensp
ENSMUSP00000032888
resolver
enst
ENSMUST00000032888
resolver
genesymbol
Arl6ip1
resolver
genesymbol_syn
Arl6ip
resolver
uniprot
Q80ZW9
resolver
uniprot
Q9JLI9
resolver
uniprot
Q9WUG3
resolver
uniprot_entry
AR6P1_MOUSE
resolver
uniprot_entry
Q80ZW9_MOUSE
resolver
uniprot_sec
Q9JLI9
resolver
uniprot_sec
Q9WUG3
resolver
amino_acid_sequence
MAEGDNRSSNLLAVETASLEEQLQGWGEVMLMADKVLRWERAWFPPAIMGVVSLLFLIIYYLDPSVLSGVSCFVMFLCLADYLVPILAPRIFGSNKWTTEQQQRFHEICSNLVKTRRRAVGWWKRLFSLKEEKPKMYFMTMIISLAAVAWVGQQVHNLLLTYLIVTFVLLLPGLNQHGIILKYIGMAKREINKLLKQKEKKNE
uniprot
proteins
function
FUNCTION: Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (PubMed:18684713). Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (By similarity). {ECO:0000250|UniProtKB:Q15041, ECO:0000269|PubMed:18684713}.
uniprot
proteins
mass_dalton
23437
uniprot
proteins
protein_family
ARL6ip family
uniprot
proteins
pubmed
10508919
uniprot
proteins
pubmed
10995579
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18684713
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250|UniProtKB:Q15041}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15041}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:18684713}. Note=Predominantly localized to intracytoplasmic membranes. Preferentially localizes at the ER tubules and the edge of the ER sheets, both of which are characterized by a high membrane curvature. {ECO:0000250|UniProtKB:Q15041}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..62; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 66..86; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 134..175; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins