PTPN6
entrez
5777
canonical
uniprot
P29350
canonical
ensembl
ENSG00000111679
resolver
ensp
ENSP00000326010
resolver
ensp
ENSP00000382376
resolver
ensp
ENSP00000391592
resolver
ensp
ENSP00000547830
resolver
genesymbol
PTPN6
resolver
genesymbol_syn
HCP
resolver
genesymbol_syn
PTP1C
resolver
hgnc
HGNC:9658
resolver
uniprot
A8K306
resolver
uniprot
G3V0F8
resolver
uniprot
Q53XS4
resolver
uniprot
Q969V8
resolver
uniprot
Q9UK67
resolver
uniprot_entry
PTN6_HUMAN
resolver
uniprot_entry
Q53XS4_HUMAN
resolver
uniprot_sec
A8K306
resolver
uniprot_sec
G3V0F8
resolver
uniprot_sec
Q969V8
resolver
uniprot_sec
Q9UK67
resolver
amino_acid_sequence
MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}.
uniprot
proteins
mass_dalton
67561
uniprot
proteins
mutagenesis
MUTAGEN 308; /note="K->R: Almost complete loss of ubiquitination by ITCH and WWP2."; /evidence="ECO:0000269|PubMed:29925997"; MUTAGEN 419; /note="D->A: No loss in substrate binding but impaired activity."; /evidence="ECO:0000269|PubMed:11907092"; MUTAGEN 453; /note="C->S: Stabilizes the association between phosphatase and substrates."; /evidence="ECO:0000269|PubMed:37595871"; MUTAGEN 564; /note="Y->F: Complete loss of phosphorylation by LYN."; /evidence="ECO:0000269|PubMed:10574931
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 by LYN enhances phosphatase activity. Phosphorylation at Thr-394 by TAOK3 leads to polyubiquitination and subsequent proteasomal degradation (PubMed:38166031). {ECO:0000250|UniProtKB:P29351, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:7781604}.; PTM: Ubiquitinated after phosphorylation by TAOK3 (PubMed:38166031). Ubiquitinated by a cooperation between ITCH and WWP2 via 'Lys-27'-mediated polyubiquitin chains resulting in the reduction of its association with LCK (PubMed:29925997). {ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:38166031}.
uniprot
proteins
protein_family
Non-receptor class 2 subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
10497187
uniprot
proteins
pubmed
10574931
uniprot
proteins
pubmed
11162587
uniprot
proteins
pubmed
11266449
uniprot
proteins
pubmed
11414741
uniprot
proteins
pubmed
11907092
uniprot
proteins
pubmed
12482860
uniprot
proteins
pubmed
14597715
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14739280
uniprot
proteins
pubmed
15184070
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15526160
uniprot
proteins
pubmed
16129412
uniprot
proteins
pubmed
16493035
uniprot
proteins
pubmed
1652101
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
1732748
uniprot
proteins
pubmed
1736296
uniprot
proteins
pubmed
17562706
uniprot
proteins
pubmed
18604210
uniprot
proteins
pubmed
19591923
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19843936
uniprot
proteins
pubmed
20351292
uniprot
proteins
pubmed
20933011
uniprot
proteins
pubmed
21258366
uniprot
proteins
pubmed
21262353
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21465528
uniprot
proteins
pubmed
23112346
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29925997
uniprot
proteins
pubmed
34811497
uniprot
proteins
pubmed
37595871
uniprot
proteins
pubmed
37932456
uniprot
proteins
pubmed
38166031
uniprot
proteins
pubmed
38532423
uniprot
proteins
pubmed
7665165
uniprot
proteins
pubmed
7781604
uniprot
proteins
pubmed
9065461
uniprot
proteins
pubmed
9074930
uniprot
proteins
pubmed
9151699
uniprot
proteins
pubmed
9285411
uniprot
proteins
pubmed
9712903
uniprot
proteins
pubmed
9733788
uniprot
proteins
pubmed
9774441
uniprot
proteins
pubmed
9842885
uniprot
proteins
sequence_length
595
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:9065461}. Nucleus {ECO:0000269|PubMed:37595871}. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. {ECO:0000250}.
uniprot
proteins