Cwc22
entrez
80744
canonical
uniprot
Q8C5N3
canonical
ensembl
ENSMUSG00000027014
resolver
ensp
ENSMUSP00000064947
resolver
ensp
ENSMUSP00000107449
resolver
ensp
ENSMUSP00000107450
resolver
ensp
ENSMUSP00000107452
resolver
ensp
ENSMUSP00000107455
resolver
ensp
ENSMUSP00000303800
resolver
ensp
ENSMUSP00000303801
resolver
ensp
ENSMUSP00000303802
resolver
ensp
ENSMUSP00000303803
resolver
ensp
ENSMUSP00000303805
resolver
ensp
ENSMUSP00000303820
resolver
ensp
ENSMUSP00000303823
resolver
ensp
ENSMUSP00000303824
resolver
enst
ENSMUST00000111819
resolver
enst
ENSMUST00000111824
resolver
genesymbol
Cwc22
resolver
genesymbol_syn
Ncm
resolver
uniprot
B1AYU4
resolver
uniprot
B1AYU7
resolver
uniprot
Q3UEH0
resolver
uniprot
Q3V267
resolver
uniprot
Q8BKP8
resolver
uniprot
Q8BR58
resolver
uniprot
Q99KV6
resolver
uniprot_entry
B1AYU4_MOUSE
resolver
uniprot_entry
B1AYU7_MOUSE
resolver
uniprot_entry
CWC22_MOUSE
resolver
uniprot_entry
Q8BKP8_MOUSE
resolver
uniprot_sec
Q3UEH0
resolver
uniprot_sec
Q3V267
resolver
uniprot_sec
Q8BR58
resolver
uniprot_sec
Q99KV6
resolver
amino_acid_sequence
MKSSVAHMKSSGHNRRETHSSYRRSSSPEDRYTEQERSPRDRGYSDYSRSDYERSRRGYSYDDSMESRSRDREKRRERERDADHRKRSRKSPSPDRSPARGGGQSSPQEEPTWKKKKDELDPLLTRTGGAYIPPAKLRMMQEQITDKSSLAYQRMSWEALKKSINGLINKVNISNISIIIQELLQENIVRGRGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNFRKGYRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGFLKECGLKLTQVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFKDHPVILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKYKAIKKEILDEGDSDSNTDQGAGSSEDEEEEDEEEEGEDEEGGQKVTIHDKTEINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFAESQTKELCNMILDCCAQQRTYEKFFGLLAGRFCMLKKEYMESFESIFKEQYDTIHRLETNKLRNVAKMFAHLLYTDSLPWSVLECIKLSEETTTSSSRIFVKIFFQELCEYMGLPKLNARLKDETLQPFFEGLLPRDNPRNTRFAINFFTSIGLGGLTDELREHLKNTPKVIVAQKPEAEQKKPALTSSSSESSSASDSSDSESDSSESSSESSSDASDSSSSSSTQSSTSGITAHSAKGTRKKRQGKARGEEVDKLARGHQALERRREGGREDQRHQEGRTERARSERRRAQNSRDADWRDPLAKHIDDRSHENSHSRVGNGREQGSHREPEDRHGEPKKRRERRDSFSENEKQRSRNQDSDNVRRKDRSKSRERSRRHSGHKGDDARCQNSAERRWEKPGRRPEQSRESKRSQDRRREKSPTTQK
uniprot
proteins
function
FUNCTION: Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000250|UniProtKB:Q9HCG8}.
uniprot
proteins
mass_dalton
104773
uniprot
proteins
protein_family
CWC22 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
908
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9HCG8}. Nucleus speckle {ECO:0000250|UniProtKB:Q9HCG8}. Note=Concentrates around speckles, which are sites of pre-mRNA synthesis and processing, where it colocalizes with EJC core proteins. {ECO:0000250|UniProtKB:Q9HCG8}.
uniprot
proteins