LYAR
entrez
55646
canonical
uniprot
Q9NX58
canonical
ensembl
ENSG00000145220
resolver
ensp
ENSP00000345917
resolver
ensp
ENSP00000397367
resolver
ensp
ENSP00000540405
resolver
ensp
ENSP00000615782
resolver
enst
ENST00000343470
resolver
enst
ENST00000452476
resolver
enst
ENST00000870346
resolver
enst
ENST00000945723
resolver
genesymbol
LYAR
resolver
hgnc
HGNC:26021
resolver
uniprot
D3DVS4
resolver
uniprot
Q6FI78
resolver
uniprot
Q9NYS1
resolver
uniprot_entry
LYAR_HUMAN
resolver
uniprot_sec
D3DVS4
resolver
uniprot_sec
Q6FI78
resolver
uniprot_sec
Q9NYS1
resolver
amino_acid_sequence
MVFFTCNACGESVKKIQVEKHVSVCRNCECLSCIDCGKDFWGDDYKNHVKCISEDQKYGGKGYEGKTHKGDIKQQAWIQKISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKNSLKVHNESILDQVWNIFSEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDEHHRSEEELLVIFNKKISKNPTFKLLKDKVKLVK
uniprot
proteins
function
FUNCTION: Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131). In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (PubMed:31413131). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity). {ECO:0000250|UniProtKB:Q08288, ECO:0000269|PubMed:24495227, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:28686580, ECO:0000269|PubMed:31413131}.
uniprot
proteins
mass_dalton
43634
uniprot
proteins
mutagenesis
MUTAGEN 1..58; /note="Missing: Decreases the production of 28S rRNA and the formation of pre-60S particle."; /evidence="ECO:0000269|PubMed:24495227
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24495227
uniprot
proteins
pubmed
24990247
uniprot
proteins
pubmed
25092918
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
26203195
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28686580
uniprot
proteins
pubmed
31413131
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:31413131}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:24495227}. Cytoplasm {ECO:0000269|PubMed:24990247}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q08288}. Note=Component of pre-ribosomal particles, including pre-40S, pre-60S and pre-90S (PubMed:24495227). Associated with cytoplasmic ribosomes, but not polysomes, as a component of the 60S subunit (PubMed:24990247). In the retina, predominantly expressed in photoreceptor outer segments (By similarity). In the nucleolus, colocalizes with nucleolin/NCL, therefore may reside in the dense fibrillar component (DFC) (By similarity). {ECO:0000250|UniProtKB:Q08288, ECO:0000269|PubMed:24495227, ECO:0000269|PubMed:24990247}.
uniprot
proteins