NUDT15
entrez
55270
canonical
uniprot
Q9NV35
canonical
ensembl
ENSG00000136159
resolver
ensp
ENSP00000258662
resolver
ensp
ENSP00000545762
resolver
ensp
ENSP00000583195
resolver
ensp
ENSP00000583196
resolver
ensp
ENSP00000775623
resolver
enst
ENST00000258662
resolver
enst
ENST00000875703
resolver
enst
ENST00000913136
resolver
enst
ENST00000913137
resolver
genesymbol
NUDT15
resolver
genesymbol_syn
MTH2
resolver
hgnc
HGNC:23063
resolver
uniprot
A2RUR6
resolver
uniprot
Q32Q27
resolver
uniprot
Q6P2C9
resolver
uniprot_entry
NUD15_HUMAN
resolver
uniprot_sec
A2RUR6
resolver
uniprot_sec
Q32Q27
resolver
uniprot_sec
Q6P2C9
resolver
amino_acid_sequence
MTASAQPRGRRPGVGVGVVVTSCKHPRCVLLGKRKGSVGAGSFQLPGGHLEFGETWEECAQRETWEEAALHLKNVHFASVVNSFIEKENYHYVTILMKGEVDVTHDSEPKNVEPEKNESWEWVPWEELPPLDQLFWGLRCLKEQGYDPFKEDLNHLVGYKGNHL
uniprot
proteins
ec_number
3.6.1.68
uniprot
proteins
ec_number
3.6.1.76
uniprot
proteins
ec_number
3.6.1.9
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:22556419, PubMed:26238318). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (PubMed:25108385, PubMed:26238318). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity). In vitro, it catalyzes the hydrolysis of isoprene pyrophosphates, including (2E)-geranyl diphosphate, isopentenyl diphosphate, (2E,6E)-farnesyl diphosphate and dimethylallyl diphosphate (PubMed:38944687). It may therefore play a role in the control of cellular levels of these metabolites that are essential for multiple cellular processes, including isoprenoids synthesis and protein isoprenylation (Probable). {ECO:0000250|UniProtKB:Q8BG93, ECO:0000269|PubMed:19419956, ECO:0000269|PubMed:22556419, ECO:0000269|PubMed:25108385, ECO:0000269|PubMed:26238318, ECO:0000269|PubMed:38944687, ECO:0000305|PubMed:38944687}.
uniprot
proteins
mass_dalton
18609
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="H->A: Loss of hydrolase activity with (2E)-geranyl diphosphate as substrate. Severely decreased hydrolase activity with dGTP as substrate. 16-fold increased KM for dGTP."; /evidence="ECO:0000269|PubMed:38944687
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19419956
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22556419
uniprot
proteins
pubmed
25108385
uniprot
proteins
pubmed
26238318
uniprot
proteins
pubmed
26878724
uniprot
proteins
pubmed
38944687
uniprot
proteins
pubmed
8810257
uniprot
proteins
sequence_length
164
uniprot
proteins