Mcmbp
entrez
210711
canonical
uniprot
Q8R3C0
canonical
ensembl
ENSMUSG00000048170
resolver
ensp
ENSMUSP00000062843
resolver
enst
ENSMUST00000057557
resolver
genesymbol
Mcmbp
resolver
uniprot
D3Z3G1
resolver
uniprot_entry
MCMBP_MOUSE
resolver
uniprot_sec
D3Z3G1
resolver
amino_acid_sequence
MPCGEDWLSHPLGIVQGFFAQNGVNPDWEKKVIEYFKEKLKENNAPKWVPSLNEVPLHYLKPNSFVKFRCMIQDMFDPEFYMGIYETVNQNTKARVLHFGKYRDVAECGPQQELDLSSPRSTTSERQTFYCVPVPGESSWVKEAYVNANQARVSPSTSYTPSRHKRSYEDDEDMDLQPSKQKEQHPGSRQAGGLGGLHWCGEPKRLETEASSGQQLNTLNLSSPFDLNFPLPGEKGPACLVKVYEDWDCFKVNDVLELYGVLSVDPVLSVLNSEERDASALLDPMECTDMAEEQRVHSPPASLVPRIHVILAQKLQHINPLLPTCLNKEESRSCQFVSNFMSELSPVRAELLGFLTHALLGDSLAAEYLILHLISTVYTRRDVLPLGKFTVNLSGCPQNSTFTEHLYRIIQHLVPASFRLQMTIENMNQLKLIPHKDYTANRLVSGLLQLPNNTSLVIDETLLEQGQLDTPGVHNVTALSNLITWQKVDYDFSYHQMEFPCNINVLITSEGRSLLPADCQIHLQPQLIPPNMEEYMNGLLSAVLPSVLNKFRIYLTLLRFLDYNLSDDITKAVEDDFVEMRKDDPQSITADDLHQLLVVARFLSLSVGQTTLSRERWLRAKQLELSRKARLQQQKSVNGNEL
uniprot
proteins
function
FUNCTION: Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
72891
uniprot
proteins
protein_family
MCMBP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
642
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex (By similarity). {ECO:0000250}.
uniprot
proteins