F2RL3
entrez
9002
canonical
uniprot
Q96RI0
canonical
ensembl
ENSG00000127533
resolver
ensp
ENSP00000248076
resolver
enst
ENST00000248076
resolver
genesymbol
F2RL3
resolver
genesymbol_syn
PAR4
resolver
hgnc
HGNC:3540
resolver
uniprot
O76067
resolver
uniprot
Q6DK42
resolver
uniprot_entry
PAR4_HUMAN
resolver
uniprot_sec
O76067
resolver
uniprot_sec
Q6DK42
resolver
activity_regulation
ACTIVITY REGULATION: Activated upon interaction by mucunain, a cowhage (Mucuna pruriens) plant cysteine proteinase. {ECO:0000269|PubMed:18434511}.
uniprot
proteins
amino_acid_sequence
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
uniprot
proteins
function
FUNCTION: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis (PubMed:10079109). May play a role in platelets activation (PubMed:10079109). {ECO:0000269|PubMed:10079109}.
uniprot
proteins
mass_dalton
41133
uniprot
proteins
mutagenesis
MUTAGEN 47; /note="R->A: No proteolytic cleavage (by thrombin or trypsin)."; /evidence="ECO:0000269|PubMed:9618465"; MUTAGEN 68; /note="R->A: No effect on receptor activation."; /evidence="ECO:0000269|PubMed:9618465
uniprot
proteins
post_translational_modification
PTM: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10079109
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18434511
uniprot
proteins
pubmed
9618465
uniprot
proteins
pubmed
9716134
uniprot
proteins
pubmed
9722561
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 83..103; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 109..129; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 152..172; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 248..268; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 284..304; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 320..343; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins