DHRS9
entrez
10170
canonical
uniprot
Q9BPW9
canonical
ensembl
ENSG00000073737
resolver
ensp
ENSP00000350154
resolver
ensp
ENSP00000389241
resolver
ensp
ENSP00000407167
resolver
ensp
ENSP00000407747
resolver
ensp
ENSP00000502399
resolver
ensp
ENSP00000537702
resolver
ensp
ENSP00000537705
resolver
genesymbol
DHRS9
resolver
genesymbol_syn
RDH15
resolver
genesymbol_syn
SDR9C4
resolver
hgnc
HGNC:16888
resolver
uniprot
B7Z416
resolver
uniprot
D3DPC1
resolver
uniprot
Q5RKX1
resolver
uniprot
Q9NRA9
resolver
uniprot
Q9NRB0
resolver
uniprot_entry
DHRS9_HUMAN
resolver
uniprot_sec
B7Z416
resolver
uniprot_sec
D3DPC1
resolver
uniprot_sec
Q5RKX1
resolver
uniprot_sec
Q9NRA9
resolver
uniprot_sec
Q9NRB0
resolver
amino_acid_sequence
MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLKQKAELANPKAV
uniprot
proteins
ec_number
1.1.1.105
uniprot
proteins
ec_number
1.1.1.209
uniprot
proteins
ec_number
1.1.1.53
uniprot
proteins
function
FUNCTION: 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (PubMed:11294878, PubMed:29541409). Also plays a role in the biosynthesis of retinoic acid from retinaldehyde (PubMed:11304534, PubMed:12618084). Can utilize both NADH and NADPH. {ECO:0000250|UniProtKB:Q8VD48, ECO:0000269|PubMed:11294878, ECO:0000269|PubMed:11304534, ECO:0000269|PubMed:12618084, ECO:0000269|PubMed:29541409}.
uniprot
proteins
mass_dalton
35227
uniprot
proteins
mutagenesis
MUTAGEN 176; /note="Y->F: Decreases androsterone dehydrogenase activity; when associated with R-180."; /evidence="ECO:0000269|PubMed:29541409"; MUTAGEN 180; /note="K->R: Decreases androsterone dehydrogenase activity; when associated with F-176."; /evidence="ECO:0000269|PubMed:29541409
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
10800688
uniprot
proteins
pubmed
11294878
uniprot
proteins
pubmed
11304534
uniprot
proteins
pubmed
12618084
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19027726
uniprot
proteins
pubmed
29541409
uniprot
proteins
sequence_length
319
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:11294878, ECO:0000269|PubMed:11304534, ECO:0000269|PubMed:12618084}. Endoplasmic reticulum membrane {ECO:0000305}. Note=Associated with microsomal membranes.
uniprot
proteins