Hjv
entrez
69585
canonical
uniprot
Q7TQ32
canonical
ensembl
ENSMUSG00000038403
resolver
ensp
ENSMUSP00000046659
resolver
ensp
ENSMUSP00000248402
resolver
ensp
ENSMUSP00000248403
resolver
genesymbol
Hjv
resolver
genesymbol_syn
Hfe2
resolver
genesymbol_syn
Rgmc
resolver
uniprot
Q8CEU7
resolver
uniprot
Q8K1D4
resolver
uniprot
Q9D741
resolver
uniprot_entry
RGMC_MOUSE
resolver
uniprot_sec
Q8CEU7
resolver
uniprot_sec
Q8K1D4
resolver
uniprot_sec
Q9D741
resolver
amino_acid_sequence
MGQSPSPRSPHGSPPTLSTLTLLLLLCGQAHSQCKILRCNAEYVSSTLSLRGGGSPDTPRGGGRGGLASGGLCRALRSYALCTRRTARTCRGDLAFHSAVHGIEDLMIQHNCSRQGPTAPPPARGPALPGAGPAPLTPDPCDYEARFSRLHGRAPGFLHCASFGDPHVRSFHNQFHTCRVQGAWPLLDNDFLFVQATSSPVSSGANATTIRKITIIFKNMQECIDQKVYQAEVDNLPAAFEDGSINGGDRPGGSSLSIQTANLGSHVEIRAAYIGTTIIIRQTAGQLSFSIRVAEDVARAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAIAIDTARRLCKEGLPVEDAYFQSCVFDVSVSGDPNFTVAAQTALDDARIFLTDLENLHLFPSDAGPPLSPAICLVPLLSALFVLWLCFSK
uniprot
proteins
function
FUNCTION: Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis. {ECO:0000269|PubMed:16604073, ECO:0000269|PubMed:19252486}.
uniprot
proteins
mass_dalton
44848
uniprot
proteins
post_translational_modification
PTM: Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space; regulates HJV activity in BMP signaling and thefore iron homeostasis. {ECO:0000250|UniProtKB:Q6ZVN8}.
uniprot
proteins
protein_family
Repulsive guidance molecule (RGM) family
uniprot
proteins
pubmed
14678836
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16604073
uniprot
proteins
pubmed
19252486
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Note=Also released in the extracellular space. {ECO:0000250|UniProtKB:Q6ZVN8}.
uniprot
proteins