PRR5L
entrez
79899
canonical
uniprot
Q6MZQ0
canonical
ensembl
ENSG00000135362
resolver
ensp
ENSP00000368144
resolver
ensp
ENSP00000435050
resolver
ensp
ENSP00000435241
resolver
genesymbol
PRR5L
resolver
genesymbol_syn
PROTOR2
resolver
hgnc
HGNC:25878
resolver
uniprot
A4QN22
resolver
uniprot
B3KNU3
resolver
uniprot
E9PKY1
resolver
uniprot
Q96H46
resolver
uniprot
Q9H7V4
resolver
uniprot_entry
B3KNU3_HUMAN
resolver
uniprot_entry
PRR5L_HUMAN
resolver
uniprot_sec
A4QN22
resolver
uniprot_sec
E9PKY1
resolver
uniprot_sec
Q96H46
resolver
uniprot_sec
Q9H7V4
resolver
amino_acid_sequence
MTRGFAPILPVEFHKMGSFRRPRPRFMSSPVLSDLPRFQAARQALQLSSSSAWNSVQTAVINVFKGGGLQSNELYALNENIRRLLKSELGSFITDYFQNQLLAKGLFFVEEKIKLCEGENRIEVLAEVWDHFFTETLPTLQAIFYPVQGQELTIRQISLLGFRDLVLLKVKLGDLLLLAQSKLPSSIVQMLLILQSVHEPTGPSESYLQLEELVKQVVSPFLGISGDRSFSGPTYTLARRHSRVRPKVTVLNYASPITAVSRPLNEMVLTPLTEQEGEAYLEKCGSVRRHTVANAHSDIQLLAMATMMHSGLGEEASSENKCLLLPPSFPPPHRQCSSEPNITDNPDGLEEGARGSQEGSELNCASLS
uniprot
proteins
function
FUNCTION: Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062). {ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:21964062, ECO:0000269|PubMed:22609986}.
uniprot
proteins
mass_dalton
40836
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid. {ECO:0000269|PubMed:22609986}.
uniprot
proteins
protein_family
PROTOR family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17461779
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21964062
uniprot
proteins
pubmed
22609986
uniprot
proteins
sequence_length
368
uniprot
proteins