Pafah1b3
entrez
18476
canonical
uniprot
Q61205
canonical
ensembl
ENSMUSG00000005447
resolver
ensp
ENSMUSP00000005583
resolver
ensp
ENSMUSP00000120379
resolver
ensp
ENSMUSP00000163465
resolver
ensp
ENSMUSP00000163468
resolver
enst
ENSMUST00000005583
resolver
enst
ENSMUST00000155118
resolver
genesymbol
Pafah1b3
resolver
genesymbol_syn
Pafahg
resolver
uniprot
F6VTR1
resolver
uniprot
Q3TJC2
resolver
uniprot
Q8CA83
resolver
uniprot_entry
F6VTR1_MOUSE
resolver
uniprot_entry
PA1B3_MOUSE
resolver
uniprot_entry
Q3TJC2_MOUSE
resolver
uniprot_entry
Q8CA83_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Beta subunit (PAFAH1B1) inhibits the acetylhydrolase activity of the alpha1/alpha1 catalytic homodimer. {ECO:0000250|UniProtKB:Q29460}.
uniprot
proteins
amino_acid_sequence
MSGEGENPASKPTPVQDVQGDGRWMSLHHRFVADSKDKEPEVVFIGDSLVQLMHQCEIWRELFSPLHALNFGIGGDSTQHVLWRLENGELEHIRPKIVVVWVGTNNHSHTAEQVTGGIKAIVQLVNKLQPQARVVVLGLLPRGQHPNPLREKNRQVNELVRAALAGYPRAHFLDADPGFVHSDGTISHHDMYDYLHLSRLGYTPVCRALHSLLLRLLAQDQGQGIPLPETAS
uniprot
proteins
ec_number
3.1.1.47
uniprot
proteins
function
FUNCTION: Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain. {ECO:0000250|UniProtKB:Q29460}.
uniprot
proteins
mass_dalton
25853
uniprot
proteins
protein_family
'GDSL' lipolytic enzyme family
uniprot
proteins
protein_family
Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily
uniprot
proteins
pubmed
12775763
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17330141
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8954729
uniprot
proteins
sequence_length
232
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins