Traf3ip1
entrez
74019
canonical
uniprot
Q149C2
canonical
ensembl
ENSMUSG00000034292
resolver
ensp
ENSMUSP00000042391
resolver
ensp
ENSMUSP00000140151
resolver
ensp
ENSMUSP00000315161
resolver
enst
ENSMUST00000047242
resolver
enst
ENSMUST00000189341
resolver
genesymbol
Traf3ip1
resolver
genesymbol_syn
Ift54
resolver
genesymbol_syn
Mipt3
resolver
uniprot
A0A087WQD8
resolver
uniprot
Q538H5
resolver
uniprot
Q80VQ3
resolver
uniprot
Q9CS98
resolver
uniprot_entry
A0A087WQD8_MOUSE
resolver
uniprot_entry
MIPT3_MOUSE
resolver
uniprot_sec
Q538H5
resolver
uniprot_sec
Q80VQ3
resolver
uniprot_sec
Q9CS98
resolver
amino_acid_sequence
MNAAVVRRTQEALGKVIRRPPLTEKLLNKPPFRYLHDIITEVIRITGFMKGLYTDAEMKSENVKDKDAKISFLQKAIDVVMMVSGEPLAAKPARIVAGHEPERTNELLQLIGKCCLSKLSSDEAVKRVLAGDKGDSRGRAQRTSKAQEPNNKSGKEEESRIHKEDKRSSEAKERSASAEHKQKEELKEDSKPREKERDKEKAKEADRDRHRDPDRDRNRDGEREKARARAKDRDRNNRDRDREAERDRERDRRSEGGKEKERVKDRDRDRDKGRDRERRKSKNGEHTRDPDREKSRDADKPEKKSSSSGEISRKLSDGSFKDVKAEMEADISVGASRSSTLKPSKRRSKHSLEGDSPSDAEVEAGPAGQDKPEVMENAEVPSELPSSLRRIPRPGSARPAPPRVKRQESTETLVVDRSGSGKTVSSVIIDSQNSDNEDDEQFVVEAAPQLSEIADIDMVPSGELEDEEKHGGLVKKILETKKDYEKLQQSLKPGEKERSLIFESAWKKEKDIVSKEIEKLRVSIQTLCKSALPLGKIMDYIQEDVDAMQNELQLWHSENRQHAEALSQEQSITDSAVEPLKAELSELEQQIRDQQDKICAVKANILKNEEKIQKMVHSINLSSRR
uniprot
proteins
function
FUNCTION: Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (By similarity). Involved in epithelial morphogenesis and in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (PubMed:21945076). {ECO:0000250|UniProtKB:Q8TDR0, ECO:0000269|PubMed:21945076, ECO:0000269|PubMed:26487268}.
uniprot
proteins
mass_dalton
71037
uniprot
proteins
mutagenesis
MUTAGEN 453; /note="I->R: Decreased interaction with MAP4. No effect on interaction with IFT20.
uniprot
proteins
protein_family
IFT54 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19253336
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21945076
uniprot
proteins
pubmed
26487268
uniprot
proteins
sequence_length
625
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8TDR0}. Cell projection, cilium {ECO:0000269|PubMed:19253336}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:21945076}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:21945076}. Note=Microtubules. In the cilium, it is observed at the ciliary base, ciliary transition zone and ciliary tip. {ECO:0000250|UniProtKB:Q8TDR0}.
uniprot
proteins