Rec114
entrez
73673
canonical
uniprot
Q9CWH4
canonical
ensembl
ENSMUSG00000074269
resolver
ensp
ENSMUSP00000096271
resolver
ensp
ENSMUSP00000337396
resolver
ensp
ENSMUSP00000337399
resolver
ensp
ENSMUSP00000337400
resolver
enst
ENSMUST00000098674
resolver
genesymbol
Rec114
resolver
uniprot_entry
RE114_MOUSE
resolver
amino_acid_sequence
MSEAGNVASGLGLPGEVSQWSLKRYGRFMLLDNVGSPGPSSEAAAAGSPTWKVFESSEESGSLVLTIVVSGHFFISQGQTLLEGFSLIGSKNWLKIVRRMDCLLFGTTIKNKSRMFRVQFSGESKEEALERCCGCVQTLAQYVTVQEPDSTTQELQQSQGPREAGESQGKDPLQQGPSLTLEQHVCMAAGAGVLQERTSVTHRAQSILAPEKLTLAYEGSSWGTEELGPFLRLCLMDQNFPAFVEEVEKELKKITGLRN
uniprot
proteins
function
FUNCTION: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:20551173, PubMed:27723721, PubMed:30569039, PubMed:36396648). Activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721, PubMed:30569039). Required for both spermatogenesis and oogenesis (PubMed:30569039). {ECO:0000269|PubMed:20551173, ECO:0000269|PubMed:27723721, ECO:0000269|PubMed:30569039, ECO:0000269|PubMed:36396648}.
uniprot
proteins
mass_dalton
28211
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="R->A: Strongly reduced interaction with ANKRD31."; /evidence="ECO:0000269|PubMed:31003867"; MUTAGEN 28; /note="F->A: Strongly reduced interaction with ANKRD31; when associated with A-104."; /evidence="ECO:0000269|PubMed:31003867"; MUTAGEN 74; /note="F->A: Strongly reduced interaction with ANKRD31; when associated with A-81."; /evidence="ECO:0000269|PubMed:31003867"; MUTAGEN 81; /note="L->A: Strongly reduced interaction with ANKRD31; when associated with A-74."; /evidence="ECO:0000269|PubMed:31003867"; MUTAGEN 104; /note="L->A: Strongly reduced interaction with ANKRD31; when associated with A-28."; /evidence="ECO:0000269|PubMed:31003867
uniprot
proteins
protein_family
REC114 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20551173
uniprot
proteins
pubmed
27723721
uniprot
proteins
pubmed
30569039
uniprot
proteins
pubmed
31000436
uniprot
proteins
pubmed
31003867
uniprot
proteins
pubmed
36396648
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:30569039}. Note=Located in discrete foci on the axes of meiotic chromosomes. The number of foci is highest at leptonema and decreases at zygonema. {ECO:0000269|PubMed:30569039}.
uniprot
proteins