Marveld2
entrez
218518
canonical
uniprot
Q3UZP0
canonical
ensembl
ENSMUSG00000021636
resolver
ensp
ENSMUSP00000022137
resolver
ensp
ENSMUSP00000129990
resolver
ensp
ENSMUSP00000153294
resolver
enst
ENSMUST00000022137
resolver
enst
ENSMUST00000163163
resolver
enst
ENSMUST00000225754
resolver
genesymbol
Marveld2
resolver
genesymbol_syn
Mrvldc2
resolver
genesymbol_syn
Tric
resolver
uniprot
A1BQX3
resolver
uniprot
E9Q1T5
resolver
uniprot
Q80UJ4
resolver
uniprot
Q99LE8
resolver
uniprot_entry
A1BQX3_MOUSE
resolver
uniprot_entry
E9Q1T5_MOUSE
resolver
uniprot_entry
MALD2_MOUSE
resolver
uniprot_sec
Q80UJ4
resolver
uniprot_sec
Q99LE8
resolver
amino_acid_sequence
MSSSDARSRIRDRGYSEVPRDTSCPDGTIRTFQSLHSSELAVSADPLPPPPLPLQPPFGPSFYSSDTEEPAVAPDLKPVRRFVPDSWKNFFRGKKKDPEWDNPVSDIRYISDGVECSPPASPARANHHPYKDPSRGSQGTFNSQHEADAMFAHDPYASLDRRTQTARTYSEKVEEYNLRYAYMKSWAGLLRILGVVELLLGAGVFACVTAYIHKDNEWYNLFGYTQPYGMGGLGSLGNTYGGYYYSGPKTPFVLVVAGLAWITTIIILVLGMSMYYRTILLDSNWWPLTEFGVNVALFILYMAAAIVYVNDTNRGGLCYYPLFNTPMNAMFCRVEGGQIAAMIFLFVTMIVYLVSALVCLKLWRHEAARRHREFLEQQEINDPSLSSKRKMCEAAISDRQRDQEVNVKDLRTTTKMTPELLSGHIPPGHIPKPIVMPDYVAKYPVIQTDDDRERYKAVFQDQFSEYKELSAEVQAILRKFDELDTVMSRLPHHSENRQEHERISRIHEEFRKKKNDPSFLEKKERCDYLKNKLSHIKQRIQEYDKVMNWDTQGYP
uniprot
proteins
function
FUNCTION: Plays a role in the formation of tricellular tight junctions and of epithelial barriers (PubMed:16365161, PubMed:21245199). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:26677943). {ECO:0000269|PubMed:16365161, ECO:0000269|PubMed:21245199, ECO:0000269|PubMed:26677943}.
uniprot
proteins
mass_dalton
63662
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ITCH; but this ubiquitination does not lead to proteasomal degradation (By similarity). Polyubiquitinated at Lys-408 via 'Lys-63'-linked ubiquitin chains; deubiquitinated by USP53 (By similarity). {ECO:0000250|UniProtKB:Q8N4S9}.; PTM: Phosphorylated. {ECO:0000269|PubMed:16365161}.
uniprot
proteins
protein_family
ELL/occludin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16365161
uniprot
proteins
pubmed
17186462
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21245199
uniprot
proteins
pubmed
23239027
uniprot
proteins
pubmed
24889144
uniprot
proteins
pubmed
25217574
uniprot
proteins
pubmed
26677943
uniprot
proteins
sequence_length
555
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16365161, ECO:0000269|PubMed:17186462, ECO:0000269|PubMed:26677943}; Multi-pass membrane protein {ECO:0000305}. Cell junction, tight junction {ECO:0000269|PubMed:16365161, ECO:0000269|PubMed:17186462, ECO:0000269|PubMed:21245199, ECO:0000269|PubMed:23239027, ECO:0000269|PubMed:24889144, ECO:0000269|PubMed:25217574, ECO:0000269|PubMed:26677943}. Note=Found at tricellular contacts. {ECO:0000269|PubMed:16365161, ECO:0000269|PubMed:17186462, ECO:0000269|PubMed:21245199, ECO:0000269|PubMed:23239027, ECO:0000269|PubMed:24889144, ECO:0000269|PubMed:25217574, ECO:0000269|PubMed:26677943}.
uniprot
proteins
transmembrane_region
TRANSMEM 192..212; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 252..272; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 339..359; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins