Kcnk9
entrez
223604
canonical
uniprot
Q3LS21
canonical
ensembl
ENSMUSG00000036760
resolver
ensp
ENSMUSP00000038729
resolver
enst
ENSMUST00000044624
resolver
genesymbol
Kcnk9
resolver
genesymbol_syn
Task3
resolver
uniprot
B2RT82
resolver
uniprot_entry
KCNK9_MOUSE
resolver
uniprot_sec
B2RT82
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by NTS:NTSR1 signaling in dentate gyrus granule cells. {ECO:0000269|PubMed:30416196}.
uniprot
proteins
amino_acid_sequence
MKRQNVRTLSLIACTFTYLLVGAAVFDALESDHEMREEEKLKAEEVRLRGKYNISSDDYQQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTEVSMENMVTVGFFSCMGTLCLGAAAFSQCEDWSFFHAYYYCFITLTTIGFGDFVALQAKGALQRKPFYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNTDEELLEGEVAEILAGNPRRVSVRAPQRRKRHHAMYFLRKYGRTLCYLCFPGTNWGKDDDDDDDDDVVDNVVVTAPISAPAPAPAPAPAPAAVAAGATIRSVRATVHTVSCRVEEIPPDVLRNTYFRSVFGAIPPGMHTCGDHRLHLRRKSI
uniprot
proteins
function
FUNCTION: K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (By similarity). Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state (By similarity). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). Allows K(+) currents with fast-gating kinetics important for the repolarization and hyperpolarization phases of action potentials (PubMed:17728447, PubMed:18250325, PubMed:30416196). In granule neurons, hyperpolarizes the resting membrane potential to limit intrinsic neuronal excitability, but once the action potential threshold is reached, supports high-frequency action potential firing and increased neuronal excitability. Homomeric and/or heteromeric KCNK3:KCNK9 channels operate in cerebellar granule cells, whereas heteromeric KCNK1:KCNK9 enables currents in hippocampal dentate gyrus granule neurons (PubMed:17728447, PubMed:30416196). Dispensable for central chemosensory respiration i.e. breathing controlled by brainstem CO2/pH, it rather conducts pH-sensitive currents and controls the firing rate of serotonergic raphe neurons involved in potentiation of the respiratory chemoreflex (PubMed:18094244). In retinal ganglion cells, mediates outward rectifying currents that regulate action potentials in response to acidification of the synaptic cleft. Involved in transmission of image-forming and nonimage-forming visual information in the retina (PubMed:36070380). In adrenal gland, contributes to the maintenance of a hyperpolarized resting membrane potential of aldosterone-producing cells at zona glomerulosa and limits aldosterone release as part of a regulatory mechanism that controls arterial blood pressure and electrolyte homeostasis (PubMed:18250325, PubMed:28630209). {ECO:0000250|UniProtKB:Q9ES08, ECO:0000250|UniProtKB:Q9NPC2, ECO:0000269|PubMed:17728447, ECO:0000269|PubMed:18094244, ECO:0000269|PubMed:18250325, ECO:0000269|PubMed:28630209, ECO:0000269|PubMed:30416196, ECO:0000269|PubMed:36070380}.
uniprot
proteins
mass_dalton
44911
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17728447
uniprot
proteins
pubmed
18094244
uniprot
proteins
pubmed
18250325
uniprot
proteins
pubmed
28630209
uniprot
proteins
pubmed
30416196
uniprot
proteins
pubmed
36070380
uniprot
proteins
sequence_length
402
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28630209, ECO:0000269|PubMed:30416196}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000305|PubMed:28630209}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:30416196}. Note=Colocalizes with MAP2 in the soma and proximal dendrites of dentate gyrus granule cells. {ECO:0000269|PubMed:30416196}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 108..128; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 159..179; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins