ATG5
entrez
9474
canonical
uniprot
Q9H1Y0
canonical
ensembl
ENSG00000057663
resolver
ensp
ENSP00000343313
resolver
ensp
ENSP00000353884
resolver
ensp
ENSP00000358072
resolver
ensp
ENSP00000490493
resolver
ensp
ENSP00000495958
resolver
ensp
ENSP00000676473
resolver
enst
ENST00000360666
resolver
enst
ENST00000646025
resolver
genesymbol
ATG5
resolver
genesymbol
DKFZp686F0183
resolver
genesymbol_syn
APG5L
resolver
genesymbol_syn
ASP
resolver
hgnc
HGNC:589
resolver
uniprot
A0A2R8Y718
resolver
uniprot
A9UGY9
resolver
uniprot
F6RDG6
resolver
uniprot
O60875
resolver
uniprot
Q5JVR2
resolver
uniprot
Q68DI4
resolver
uniprot
Q7Z3H3
resolver
uniprot
Q9H2B8
resolver
uniprot
Q9HCZ7
resolver
uniprot_entry
A0A2R8Y718_HUMAN
resolver
uniprot_entry
A9UGY9_HUMAN
resolver
uniprot_entry
ATG5_HUMAN
resolver
uniprot_entry
F6RDG6_HUMAN
resolver
uniprot_entry
Q7Z3H3_HUMAN
resolver
uniprot_sec
O60875
resolver
uniprot_sec
Q5JVR2
resolver
uniprot_sec
Q68DI4
resolver
uniprot_sec
Q9H2B8
resolver
uniprot_sec
Q9HCZ7
resolver
amino_acid_sequence
MTDDKDVLRDVWFGRIPTCFTLYQDEITEREAEPYYLLLPRVSYLTLVTDKVKKHFQKVMRQEDISEIWFEYEGTPLKWHYPIGLLFDLLASSSALPWNITVHFKSFPEKDLLHCPSKDAIEAHFMSCMKEADALKHKSQVINEMQKKDHKQLWMGLQNDRFDQFWAINRKLMEYPAEENGFRYIPFRIYQTTTERPFIQKLFRPVAADGQLHTLGDLLKEVCPSAIDPEDGEKKNQVMIHGIEPMLETPLQWLSEHLSYPDNFLHISIIPQPTD
uniprot
proteins
disease_involvement
DISEASE: Spinocerebellar ataxia, autosomal recessive, 25 (SCAR25) [MIM:617584]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR25 patients manifest delayed psychomotor development with delayed walking, truncal ataxia, dysmetria, and nystagmus, Cerebellar hypoplasia is seen on brain imaging. {ECO:0000269|PubMed:26812546}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. As part of the ATG8 conjugation system with ATG12 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). {ECO:0000250|UniProtKB:Q99J83, ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:20580051, ECO:0000269|PubMed:22170153, ECO:0000269|PubMed:26812546}.; FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. {ECO:0000269|PubMed:15778222, ECO:0000269|PubMed:7796880}.; FUNCTION: (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but not required once infection is established (PubMed:19666601). {ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:19666601}.
uniprot
proteins
mass_dalton
32447
uniprot
proteins
mutagenesis
MUTAGEN 130; /note="K->R: Loss of conjugaction with ATG12. Does affect interaction with DHX58, nor with MAVS."; /evidence="ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:9852036
uniprot
proteins
post_translational_modification
PTM: Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.; PTM: Acetylated by EP300. {ECO:0000269|PubMed:19124466}.
uniprot
proteins
protein_family
ATG5 family
uniprot
proteins
pubmed
11096062
uniprot
proteins
pubmed
11266458
uniprot
proteins
pubmed
11825910
uniprot
proteins
pubmed
12207896
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15576571
uniprot
proteins
pubmed
15778222
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
16963840
uniprot
proteins
pubmed
17709747
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19124466
uniprot
proteins
pubmed
19666601
uniprot
proteins
pubmed
20580051
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21575909
uniprot
proteins
pubmed
22170153
uniprot
proteins
pubmed
22342342
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23202584
uniprot
proteins
pubmed
24191030
uniprot
proteins
pubmed
26812546
uniprot
proteins
pubmed
32960676
uniprot
proteins
pubmed
7796880
uniprot
proteins
pubmed
9563500
uniprot
proteins
pubmed
9852036
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17709747}. Preautophagosomal structure membrane {ECO:0000269|PubMed:32960676}; Peripheral membrane protein. Note=Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Also localizes to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. Under starved conditions, the ATG12-ATG5-ATG16L1 complex is translocated to phagophores driven by RAB33B (PubMed:32960676). {ECO:0000250, ECO:0000269|PubMed:32960676}.
uniprot
proteins