Pmch
entrez
110312
canonical
uniprot
P56942
canonical
ensembl
ENSMUSG00000035383
resolver
ensp
ENSMUSP00000044352
resolver
enst
ENSMUST00000048621
resolver
genesymbol
Pmch
resolver
genesymbol_syn
Mch
resolver
uniprot
Q9D220
resolver
uniprot_entry
MCH_MOUSE
resolver
uniprot_sec
Q9D220
resolver
amino_acid_sequence
MAKMTLSSYMLMLAFSLFSQGILLSASKSIRNLEDDIVFNTFRMGKAFQKEDTAERSVVAPSLEQYKNDESGFMNDDDNKNSKNTGSKQNLVTHGLPLSLAVKPYLALKGSVAFPAENGVQNAESTQEKREIGDEENSAKFPIGRRDFDMLRCMLGRVYRPCWQV
uniprot
proteins
function
FUNCTION: [Melanin-concentrating hormone]: Neuropeptide ligand for the G protein-coupled receptor MCHR1 and MCHR2 that can activate both G(i/o)- and G(q/11)-dependent signaling pathways (By similarity). Acts as a neuromodulator in the central nervous system, promoting feeding, positive energy balance (orexigenic) and sleep (PubMed:8637571). Inhibits stimulated ACTH release (lowering plasma glucocorticoids), consistent with a role in down-regulating hypothalamic-pituitary-adrenal (HPA) axis activity. Functionally antagonizes melanotropin alpha (alpha-MSH), opposing its inhibitory effect on food intake and exploratory behaviors and its stimulatory effect on the HPA axis. Antagonizes NEI-induced behavioral effects (By similarity). May also participate in spermatocyte differentiation (PubMed:8724342). {ECO:0000250|UniProtKB:P14200, ECO:0000250|UniProtKB:P20382, ECO:0000269|PubMed:8637571, ECO:0000269|PubMed:8724342}.; FUNCTION: [Neuropeptide-glutamic acid-isoleucine]: Neuropeptide that modulates stress-related neuroendocrine responses and behaviors. Stimulates ACTH secretion, functionally counteracting the ACTH-suppressing action of MCH; the underlying mechanism is not fully characterized. Reduces dopamine and DOPAC release in the ventromedial nucleus. Influences differentiation of neuronal processes and affects neurofilament protein content in vitro. {ECO:0000250|UniProtKB:P14200}.
uniprot
proteins
mass_dalton
18516
uniprot
proteins
post_translational_modification
PTM: Pro-MCH is processed differentially in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. {ECO:0000269|PubMed:10037747}.
uniprot
proteins
protein_family
MCH family
uniprot
proteins
pubmed
10037747
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8637571
uniprot
proteins
pubmed
8724342
uniprot
proteins
pubmed
9872314
uniprot
proteins
sequence_length
165
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Melanin-concentrating hormone]: Secreted {ECO:0000250|UniProtKB:P20382}.; SUBCELLULAR LOCATION: [Neuropeptide-glutamic acid-isoleucine]: Secreted {ECO:0000250|UniProtKB:P14200}.
uniprot
proteins