MMP2
entrez
4313
canonical
uniprot
P08253
canonical
ensembl
ENSG00000087245
resolver
ensp
ENSP00000219070
resolver
ensp
ENSP00000394237
resolver
ensp
ENSP00000444143
resolver
ensp
ENSP00000461421
resolver
genesymbol
MMP2
resolver
genesymbol_syn
CLG4A
resolver
hgnc
HGNC:7166
resolver
uniprot
B2R6U1
resolver
uniprot
B4DWH3
resolver
uniprot
E9PE45
resolver
uniprot
Q9UCJ8
resolver
uniprot_entry
MMP2_HUMAN
resolver
uniprot_sec
B2R6U1
resolver
uniprot_sec
B4DWH3
resolver
uniprot_sec
E9PE45
resolver
uniprot_sec
Q9UCJ8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by histatin-3 1/24 (histatin-5). {ECO:0000269|PubMed:11179305}.
uniprot
proteins
amino_acid_sequence
MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
uniprot
proteins
disease_involvement
DISEASE: Multicentric osteolysis, nodulosis, and arthropathy (MONA) [MIM:259600]: An autosomal recessive syndrome characterized by severe multicentric osteolysis with predominant involvement of the hands and feet. Additional features include coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gum hypertrophy. {ECO:0000269|PubMed:11431697, ECO:0000269|PubMed:15691365, ECO:0000269|PubMed:16542393}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.24.24
uniprot
proteins
function
FUNCTION: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.; FUNCTION: PEX, the C-terminal non-catalytic fragment of MMP2, possesses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.; FUNCTION: [Isoform 2]: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.
uniprot
proteins
mass_dalton
73882
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro. {ECO:0000269|PubMed:17435175}.; PTM: The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3). Autocatalytic cleavage in the C-terminal produces the anti-angiogenic peptide, PEX. This processing appears to be facilitated by binding integrinv/beta3. {ECO:0000269|PubMed:12879005, ECO:0000269|PubMed:9119036}.
uniprot
proteins
protein_family
Peptidase M10A family
uniprot
proteins
pubmed
10356396
uniprot
proteins
pubmed
10545322
uniprot
proteins
pubmed
10559137
uniprot
proteins
pubmed
11029402
uniprot
proteins
pubmed
11179305
uniprot
proteins
pubmed
11320090
uniprot
proteins
pubmed
11431697
uniprot
proteins
pubmed
11710594
uniprot
proteins
pubmed
11751392
uniprot
proteins
pubmed
11928808
uniprot
proteins
pubmed
12032297
uniprot
proteins
pubmed
12147339
uniprot
proteins
pubmed
12714657
uniprot
proteins
pubmed
12879005
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14766804
uniprot
proteins
pubmed
1480041
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
15691365
uniprot
proteins
pubmed
16542393
uniprot
proteins
pubmed
1655733
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17435175
uniprot
proteins
pubmed
1851724
uniprot
proteins
pubmed
18971601
uniprot
proteins
pubmed
19493954
uniprot
proteins
pubmed
2158484
uniprot
proteins
pubmed
2162831
uniprot
proteins
pubmed
21813640
uniprot
proteins
pubmed
22509276
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
2834383
uniprot
proteins
pubmed
7583664
uniprot
proteins
pubmed
8549817
uniprot
proteins
pubmed
8646777
uniprot
proteins
pubmed
9119036
uniprot
proteins
pubmed
9476898
uniprot
proteins
sequence_length
660
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:2834383}. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Mitochondrion.
uniprot
proteins