Thop1
entrez
64517
canonical
uniprot
P24155
canonical
ensembl
ENSRNOG00000019924
resolver
ensembl
ENSRNOG00055032661
resolver
ensembl
ENSRNOG00060031896
resolver
ensembl
ENSRNOG00065022268
resolver
ensp
ENSRNOP00000027045
resolver
ensp
ENSRNOP00055046544
resolver
ensp
ENSRNOP00060045756
resolver
ensp
ENSRNOP00065030722
resolver
enst
ENSRNOT00000027045
resolver
enst
ENSRNOT00055056438
resolver
enst
ENSRNOT00060055312
resolver
enst
ENSRNOT00065037968
resolver
genesymbol
Thop1
resolver
uniprot
Q66HS4
resolver
uniprot_entry
THOP1_RAT
resolver
uniprot_sec
Q66HS4
resolver
amino_acid_sequence
MKPPAACAGDVVDTVSPCSTVNHLRWDLSAQQIRALTTQLIEQTKCVYDRVGAQDFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPNKDIRAASTEADKKLSEFDVEMSMRQDVYQRVVWLQEKIPKDSLKPEAARYLERLIKLGRRNGLHLPQDTQEKIKNIKKRLSLLCIDFNKNLNEDTTFLPFTREELGGLPEDFLNSLEKTEDGKLKVTLKYPHYFPLLKKCHVPETRRLLEEAFNCRCKEENCAILKELVSLRAQKSNLLGFRTHADYVLEMNMAKTSQTVATFLDELARKLKPLGEQERAVILELKEAECAKRGLPFDGRIHAWDMRYYMNQVEETRYRVDQNLLKEYFPMQVVTRGLLAIYQELLGLTFTLEEGAAAWHEDVRLYSVRDAASGEEIGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQLAIAAMVANFTKPTPDVPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEKEPLMRMSQHYRTGGEAPEDLLEKLIKSRQANAGLFNLRQIVLAKVDQVLHTQTDVDPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLSPKVGMDYRTSILRPGGSEDASTMLKQFLGRDPKQDAFLLSKGLQVEGCEPPAC
uniprot
proteins
ec_number
3.4.24.15
uniprot
proteins
function
FUNCTION: Involved in the metabolism of neuropeptides under 20 amino acid residues long (PubMed:2261476). Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (By similarity). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (PubMed:12500972, PubMed:18077343). {ECO:0000250|UniProtKB:P52888, ECO:0000269|PubMed:12500972, ECO:0000269|PubMed:18077343, ECO:0000269|PubMed:2261476}.
uniprot
proteins
mass_dalton
78385
uniprot
proteins
protein_family
Peptidase M3 family
uniprot
proteins
pubmed
12500972
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18077343
uniprot
proteins
pubmed
2261476
uniprot
proteins
pubmed
8216239
uniprot
proteins
sequence_length
687
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47788}.
uniprot
proteins