CD209
entrez
30835
canonical
uniprot
Q9NNX6
canonical
ensembl
ENSG00000090659
resolver
ensp
ENSP00000204801
resolver
ensp
ENSP00000315407
resolver
ensp
ENSP00000315477
resolver
ensp
ENSP00000346373
resolver
ensp
ENSP00000377728
resolver
ensp
ENSP00000471137
resolver
ensp
ENSP00000471348
resolver
enst
ENST00000394173
resolver
enst
ENST00000593821
resolver
genesymbol
CD209
resolver
genesymbol_syn
CLEC4L
resolver
hgnc
HGNC:1641
resolver
uniprot
A8KAM4
resolver
uniprot
A8MVQ9
resolver
uniprot
B2R907
resolver
uniprot
B4E2A8
resolver
uniprot
G5E9C4
resolver
uniprot
M0R0P0
resolver
uniprot
Q2TB19
resolver
uniprot
Q96QP7
resolver
uniprot
Q96QP8
resolver
uniprot
Q96QP9
resolver
uniprot
Q96QQ0
resolver
uniprot
Q96QQ1
resolver
uniprot
Q96QQ2
resolver
uniprot
Q96QQ3
resolver
uniprot
Q96QQ4
resolver
uniprot
Q96QQ5
resolver
uniprot
Q96QQ6
resolver
uniprot
Q96QQ7
resolver
uniprot
Q96QQ8
resolver
uniprot
X6RB12
resolver
uniprot_entry
B2R907_HUMAN
resolver
uniprot_entry
B4E2A8_HUMAN
resolver
uniprot_entry
CD209_HUMAN
resolver
uniprot_entry
M0R0P0_HUMAN
resolver
uniprot_entry
X6RB12_HUMAN
resolver
uniprot_sec
A8KAM4
resolver
uniprot_sec
A8MVQ9
resolver
uniprot_sec
G5E9C4
resolver
uniprot_sec
Q2TB19
resolver
uniprot_sec
Q96QP7
resolver
uniprot_sec
Q96QP8
resolver
uniprot_sec
Q96QP9
resolver
uniprot_sec
Q96QQ0
resolver
uniprot_sec
Q96QQ1
resolver
uniprot_sec
Q96QQ2
resolver
uniprot_sec
Q96QQ3
resolver
uniprot_sec
Q96QQ4
resolver
uniprot_sec
Q96QQ5
resolver
uniprot_sec
Q96QQ6
resolver
uniprot_sec
Q96QQ7
resolver
uniprot_sec
Q96QQ8
resolver
amino_acid_sequence
MSDSKEPRLQQLGLLEEEQLRGLGFRQTRGYKSLAGCLGHGPLVLQLLSFTLLAGLLVQVSKVPSSISQEQSRQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTWLKAAVGELPEKSKMQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTQLKAAVERLCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASCSRDEEQFLSPAPATPNPPPA
uniprot
proteins
function
FUNCTION: Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. {ECO:0000269|PubMed:11859097}.; FUNCTION: On dendritic cells (DCs) it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates (PubMed:10721994, PubMed:10721995, PubMed:11017109, PubMed:12574325). May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2 (PubMed:11017109). Forms a first contact between DC and resting T cell, througth ICAM3 binding, facilitating the downstream DC-T cell clustering process and DC-induced proliferation of resting T Cells (PubMed:10721994, PubMed:10721995). {ECO:0000269|PubMed:10721994, ECO:0000269|PubMed:10721995, ECO:0000269|PubMed:11017109, ECO:0000269|PubMed:12574325}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2. {ECO:0000269|PubMed:11799126, ECO:0000269|PubMed:12502850, ECO:0000269|PubMed:1518869}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Ebolavirus. {ECO:0000269|PubMed:12502850, ECO:0000269|PubMed:12504546}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Cytomegalovirus. {ECO:0000269|PubMed:12433371, ECO:0000269|PubMed:22496863}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for HCV. {ECO:0000269|PubMed:15371595, ECO:0000269|PubMed:16816373}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Dengue virus. {ECO:0000269|PubMed:12682107}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Measles virus. {ECO:0000269|PubMed:16537615}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Herpes simplex virus 1. {ECO:0000269|PubMed:18796707}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Influenzavirus A. {ECO:0000269|PubMed:21191006}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for SARS-CoV. {ECO:0000269|PubMed:15140961}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus. {ECO:0000269|PubMed:24623090}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Lassa virus (PubMed:23966408). Acts as an attachment receptor for Marburg virusn. {ECO:0000269|PubMed:15479853}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Respiratory syncytial virus. {ECO:0000269|PubMed:22090124}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus. {ECO:0000269|PubMed:21767814}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for West-nile virus. {ECO:0000269|PubMed:16415006}.; FUNCTION: (Microbial infection) Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA (PubMed:16379498). Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule (PubMed:16092920, PubMed:21203928). {ECO:0000269|PubMed:16092920, ECO:0000269|PubMed:16379498, ECO:0000269|PubMed:21203928}.
uniprot
proteins
mass_dalton
45775
uniprot
proteins
mutagenesis
MUTAGEN 14..15; /note="LL->AA: Loss of antigen internalization by endocytosis."; /evidence="ECO:0000269|PubMed:11859097"; MUTAGEN 320; /note="D->A: Loss of binding to ICAM3 and HIV-1 gp120."; /evidence="ECO:0000269|PubMed:11799126"; MUTAGEN 324; /note="E->A: Loss of binding to ICAM3 and HIV-1 gp120."; /evidence="ECO:0000269|PubMed:11799126"; MUTAGEN 347; /note="E->Q: Loss of binding to ICAM3 and HIV-1 gp120."; /evidence="ECO:0000269|PubMed:11799126"; MUTAGEN 349; /note="N->D: Loss of binding to ICAM3 and HIV-1 gp120."; /evidence="ECO:0000269|PubMed:11799126"; MUTAGEN 350; /note="N->A: Loss of binding to ICAM3 and HIV-1 gp120."; /evidence="ECO:0000269|PubMed:11799126"; MUTAGEN 355; /note="D->A: Loss of binding to ICAM3 and HIV-1 gp120."; /evidence="ECO:0000269|PubMed:11799126"; MUTAGEN 365; /note="N->D: Loss of binding to ICAM3 and HIV-1 gp120."; /evidence="ECO:0000269|PubMed:11799126"; MUTAGEN 366; /note="D->A: Loss of binding to ICAM3 and HIV-1 gp120."; /evidence="ECO:0000269|PubMed:11799126
uniprot
proteins
pubmed
10721994
uniprot
proteins
pubmed
10721995
uniprot
proteins
pubmed
10975799
uniprot
proteins
pubmed
11017109
uniprot
proteins
pubmed
11257134
uniprot
proteins
pubmed
11337487
uniprot
proteins
pubmed
11384997
uniprot
proteins
pubmed
11739956
uniprot
proteins
pubmed
11799126
uniprot
proteins
pubmed
11825572
uniprot
proteins
pubmed
11859097
uniprot
proteins
pubmed
12433371
uniprot
proteins
pubmed
12502850
uniprot
proteins
pubmed
12504546
uniprot
proteins
pubmed
12574325
uniprot
proteins
pubmed
12682107
uniprot
proteins
pubmed
12692233
uniprot
proteins
pubmed
12949494
uniprot
proteins
pubmed
12960229
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14709546
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15140961
uniprot
proteins
pubmed
1518869
uniprot
proteins
pubmed
15371595
uniprot
proteins
pubmed
15479853
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15838506
uniprot
proteins
pubmed
16092920
uniprot
proteins
pubmed
16246332
uniprot
proteins
pubmed
16379498
uniprot
proteins
pubmed
16415006
uniprot
proteins
pubmed
16537615
uniprot
proteins
pubmed
16816373
uniprot
proteins
pubmed
18796707
uniprot
proteins
pubmed
21191006
uniprot
proteins
pubmed
21203928
uniprot
proteins
pubmed
21767814
uniprot
proteins
pubmed
22090124
uniprot
proteins
pubmed
22440960
uniprot
proteins
pubmed
22496863
uniprot
proteins
pubmed
22700724
uniprot
proteins
pubmed
23966408
uniprot
proteins
pubmed
24623090
uniprot
proteins
sequence_length
404
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Membrane raft {ECO:0000269|PubMed:14709546}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 7]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 8]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 9]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 10]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 11]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 12]: Secreted {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000305
uniprot
proteins