Micu1
entrez
365567
canonical
uniprot
Q6P6Q9
canonical
ensembl
ENSRNOG00000043436
resolver
ensp
ENSRNOP00000060514
resolver
genesymbol
Micu1
resolver
genesymbol_syn
Cbara1
resolver
uniprot_entry
MICU1_RAT
resolver
amino_acid_sequence
MFRLNALSALAELAVGSRWYHGTSQPTQTKRRLMLVAFLGASAVTASTGLLWKKAHAESPPSVNSKKTDAGDKGKSKDTREVSSHEGSAADTAAEPYPEEKKKKRSGFRDRKVMEYENRIRAYSTPDKIFRYFATLKVINEPGETEVFMTPQDFVRSITPNEKQPEHLGLDQYIIKRFDGKKIAQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRISERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKDGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQETAWDFALPK
uniprot
proteins
function
FUNCTION: Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains. MICU1 and MICU2 (or MICU3) form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake. At higher calcium levels, calcium-binding to MICU1 and MICU2 (or MICU3) induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU2 heterodimer away from the pore, allowing calcium permeation through the MCU channel. Also required to protect against manganese toxicity by preventing manganese uptake by MCU: mechanistically, manganese-binding to its EF-hand domains does not induce any conformational change, maintaining MCU pore occlusion. Acts as a regulator of mitochondrial cristae structure independently of its ability to regulate the mitochondrial calcium uniporter channel. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. {ECO:0000250|UniProtKB:Q9BPX6}.
uniprot
proteins
mass_dalton
54195
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-124 by AKT1 impairs its maturation and stability. {ECO:0000250|UniProtKB:Q8VCX5}.; PTM: Asymmetric dimethylation at Arg-457 by PRMT1 decreases the calcium sensitivity of MICU1 by promoting interaction with UCP2. {ECO:0000250|UniProtKB:Q9BPX6}.; PTM: Degraded by YME1L1 when not complexed as homodimer or heterodimer. Not degraded when complexed as homodimer or heterodimer; the presence of the interchain disulfide bond protecting MICU1 from degradation by YME1L1. {ECO:0000250|UniProtKB:Q9BPX6}.
uniprot
proteins
protein_family
MICU1 family
uniprot
proteins
protein_family
MICU1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q9BPX6}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9BPX6}. Note=Recruited to the mitochondrial inner membrane by EMRE/SMDT1. Also localizes to mitochondrial cristae junctions. {ECO:0000250|UniProtKB:Q9BPX6}.
uniprot
proteins