MMP3
entrez
4314
canonical
uniprot
P08254
canonical
ensembl
ENSG00000149968
resolver
ensp
ENSP00000299855
resolver
enst
ENST00000299855
resolver
genesymbol
MMP3
resolver
genesymbol_syn
STMY1
resolver
hgnc
HGNC:7173
resolver
uniprot
B2R8B8
resolver
uniprot
Q3B7S0
resolver
uniprot
Q6GRF8
resolver
uniprot_entry
MMP3_HUMAN
resolver
uniprot_sec
B2R8B8
resolver
uniprot_sec
Q3B7S0
resolver
uniprot_sec
Q6GRF8
resolver
activity_regulation
ACTIVITY REGULATION: Enzymatic activity is activated by HTRA2 in dopaminergic cells upon mitochondrial stress. {ECO:0000269|PubMed:22265821}.
uniprot
proteins
amino_acid_sequence
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
uniprot
proteins
disease_involvement
DISEASE: Coronary heart disease 6 (CHDS6) [MIM:614466]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. {ECO:0000269|PubMed:12477941, ECO:0000269|PubMed:8662692}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions.
uniprot
proteins
ec_number
3.4.24.17
uniprot
proteins
function
FUNCTION: Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9 (PubMed:11029580, PubMed:1371271). Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway (PubMed:2383557). Also acts intracellularly (PubMed:22265821). For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage (PubMed:21330369). In addition, plays a role in immune response and possesses antiviral activity against various viruses such as vesicular stomatitis virus, influenza A virus (H1N1) and human herpes virus 1 (PubMed:35940311). Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities (PubMed:35940311). {ECO:0000269|PubMed:11029580, ECO:0000269|PubMed:1371271, ECO:0000269|PubMed:21330369, ECO:0000269|PubMed:22265821, ECO:0000269|PubMed:2383557, ECO:0000269|PubMed:35940311}.
uniprot
proteins
mass_dalton
53977
uniprot
proteins
post_translational_modification
PTM: Directly cleaved by HTRA2 to produce active form. {ECO:0000269|PubMed:22265821}.
uniprot
proteins
protein_family
Peptidase M10A family
uniprot
proteins
pubmed
10422833
uniprot
proteins
pubmed
10543949
uniprot
proteins
pubmed
11029580
uniprot
proteins
pubmed
12477941
uniprot
proteins
pubmed
1371271
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21330369
uniprot
proteins
pubmed
22265821
uniprot
proteins
pubmed
2383557
uniprot
proteins
pubmed
3030290
uniprot
proteins
pubmed
3360803
uniprot
proteins
pubmed
3477804
uniprot
proteins
pubmed
35940311
uniprot
proteins
pubmed
7656014
uniprot
proteins
pubmed
8535233
uniprot
proteins
pubmed
8662692
uniprot
proteins
pubmed
8740360
uniprot
proteins
pubmed
9083493
uniprot
proteins
pubmed
9288970
uniprot
proteins
pubmed
9760240
uniprot
proteins
pubmed
9792098
uniprot
proteins
pubmed
9827994
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. Nucleus {ECO:0000269|PubMed:35940311}. Cytoplasm {ECO:0000269|PubMed:35940311}.
uniprot
proteins