TAT
entrez
6898
canonical
uniprot
P17735
canonical
ensembl
ENSG00000198650
resolver
ensp
ENSP00000348234
resolver
ensp
ENSP00000565754
resolver
ensp
ENSP00000565756
resolver
enst
ENST00000355962
resolver
enst
ENST00000895695
resolver
enst
ENST00000895697
resolver
genesymbol
TAT
resolver
hgnc
HGNC:11573
resolver
uniprot
A0A140VKB7
resolver
uniprot
B2R8I1
resolver
uniprot
D3DWS2
resolver
uniprot_entry
A0A140VKB7_HUMAN
resolver
uniprot_entry
ATTY_HUMAN
resolver
uniprot_sec
B2R8I1
resolver
uniprot_sec
D3DWS2
resolver
amino_acid_sequence
MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAKKTFNPIRAIVDNMKVKPNPNKTMISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSREEIASYYHCPEAPLEAKDVILTSGCSQAIDLCLAVLANPGQNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKSWEIDLKQLEYLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSDCKYEPLATLSTDVPILSCGGLAKRWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNADLCYGALAAIPGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYPNFIRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK
uniprot
proteins
disease_involvement
DISEASE: Tyrosinemia 2 (TYRSN2) [MIM:276600]: An inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and intellectual disability. {ECO:0000269|PubMed:1357662}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.6.1.5
uniprot
proteins
function
FUNCTION: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. {ECO:0000269|PubMed:16640556, ECO:0000269|PubMed:7999802}.
uniprot
proteins
mass_dalton
50399
uniprot
proteins
mutagenesis
MUTAGEN 294; /note="I->A: Reduced catalytic activity."; /evidence="ECO:0000269|PubMed:16640556
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.
uniprot
proteins
protein_family
Class-I pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
1357662
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16640556
uniprot
proteins
pubmed
1973834
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7908801
uniprot
proteins
pubmed
7999802
uniprot
proteins
sequence_length
454
uniprot
proteins