Dcp1a
entrez
75901
canonical
uniprot
Q91YD3
canonical
ensembl
ENSMUSG00000021962
resolver
ensp
ENSMUSP00000022535
resolver
ensp
ENSMUSP00000152897
resolver
ensp
ENSMUSP00000191723
resolver
enst
ENSMUST00000022535
resolver
enst
ENSMUST00000225196
resolver
genesymbol
Dcp1a
resolver
genesymbol_syn
Mitc1
resolver
genesymbol_syn
Smif
resolver
uniprot
Q6NZE3
resolver
uniprot_entry
DCP1A_MOUSE
resolver
uniprot_sec
Q6NZE3
resolver
amino_acid_sequence
MALSCSTVRPRRRGSALRSKMELLSRAEQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDQRPIDILEMLSRAKDEYERNQMGGSNISSPGLQPSTQLSNLGSTETLEETPSGSQDKSAPSGHKHLTVEELFGTSLPKEQPTAMGLESEDTDKLLGDASQKEPSSFLPFPFEQSGGAPQSENLGIHSAAHHTVQPEVSTPVLITPASIAQSGDKHPPSYTLPLSPVLSPTLPAEAPTTQVPHLPRNSTMIQAVKTTPRQKSPLLNQPVPELSHSSLVASQSPFRAPVSLANPAGTALPSVDLLQKLRLTPQHDQIQAQPLGKGTMAPSFSSAAGQLATPESFIEPSSKTAAARAAVSASLSNMVLAPTLQSMQQNQDPEVFSQPKVLPSAIPIAGSPLVPATTTAVSSVLLSPSVFQQTVPRAADLERKASSPSPLTVGTAESQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHAVYLQVLTKNKDNHNL
uniprot
proteins
ec_number
3.6.1.62
uniprot
proteins
function
FUNCTION: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1 (By similarity). Essential for embryonic development (PubMed:11836524). {ECO:0000250|UniProtKB:Q9NPI6, ECO:0000269|PubMed:11836524}.
uniprot
proteins
mass_dalton
65219
uniprot
proteins
protein_family
DCP1 family
uniprot
proteins
pubmed
11836524
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19861488
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33813271
uniprot
proteins
sequence_length
602
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:19861488, ECO:0000269|PubMed:33813271}. Nucleus {ECO:0000250|UniProtKB:Q9NPI6}. Note=Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (By similarity). Colocalizes with NANOS3 in the processing bodies (PubMed:19861488). {ECO:0000250|UniProtKB:Q9NPI6, ECO:0000269|PubMed:19861488}.
uniprot
proteins