Mtf1
entrez
17764
canonical
uniprot
Q07243
canonical
ensembl
ENSMUSG00000028890
resolver
ensp
ENSMUSP00000030723
resolver
ensp
ENSMUSP00000101799
resolver
enst
ENSMUST00000030723
resolver
enst
ENSMUST00000106193
resolver
genesymbol
Mtf1
resolver
genesymbol_syn
Mtf-1
resolver
uniprot
Q8BSY2
resolver
uniprot
Q9JJW8
resolver
uniprot_entry
MTF1_MOUSE
resolver
uniprot_entry
Q8BSY2_MOUSE
resolver
uniprot_sec
Q9JJW8
resolver
amino_acid_sequence
MGEHSPDDNIIFFKGEEDDLTPHDKMLRFVDDNGLVPSSSGTVYDRTTVLIEQDPGTLEDDEDDGQCGEPLPFLVEGEEGFLIDQEAMSQGYVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSECPETKRKEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESQGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGTAYSALPQHNGSEDTNHSLYLSELGLLSTDSELQENSSSTQDQDLSTISPAIIFESMFQNSDDPGIQDDPLQTAALIDSFNGDAESVIDVPPPAGNSASLSLPLVLQSGISEPPQPLLPATAPSAPPPAPSLGPGSQPAAFGSPPALLQPPEVPVPHSTQFAANHQEFLPHPQAPPQTIVPGLSVVAGAPASAATVASAVAAPAPPQSTTEPLPAMVQTLPLGANSVLTNNPTITITPTPNTAILQSSLVMGEQNLQWILNGATSSPQNQEQIQQASKVEQVYFATAVPVASGTGSSVQQIGLSVPVIIIKQEEACQCQCACRDSAKERAAGRRKGCSSPPPPEPNPQPPDGPSLQLPP
uniprot
proteins
function
FUNCTION: Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:24529376). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (By similarity). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (PubMed:24529376). {ECO:0000250|UniProtKB:Q14872, ECO:0000269|PubMed:24529376}.
uniprot
proteins
mass_dalton
72603
uniprot
proteins
pubmed
11005378
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24529376
uniprot
proteins
pubmed
8467794
uniprot
proteins
sequence_length
675
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24529376}. Cytoplasm {ECO:0000269|PubMed:24529376}. Note=Translocation to the nucleus is induced by metals. {ECO:0000269|PubMed:24529376}.
uniprot
proteins