STAP2
entrez
55620
canonical
uniprot
Q9UGK3
canonical
ensembl
ENSG00000178078
resolver
ensp
ENSP00000468927
resolver
ensp
ENSP00000471052
resolver
ensp
ENSP00000529680
resolver
genesymbol
STAP2
resolver
genesymbol_syn
BKS
resolver
hgnc
HGNC:30430
resolver
uniprot
A6NKK3
resolver
uniprot
Q9NXI2
resolver
uniprot_entry
STAP2_HUMAN
resolver
uniprot_sec
A6NKK3
resolver
uniprot_sec
Q9NXI2
resolver
amino_acid_sequence
MASALRPPRVPKPKGVLPSHYYESFLEKKGPCDRDYKKFWAGLQGLTIYFYNSNRDFQHVEKLNLGAFEKLTDEIPWGSSRDPGTHFSLILRDQEIKFKVETLECREMWKGFILTVVELRVPTDLTLLPGHLYMMSEVLAKEEARRALETPSCFLKVSRLEAQLLLERYPECGNLLLRPSGDGADGVSVTTRQMHNGTHVVRHYKVKREGPKYVIDVEQPFSCTSLDAVVNYFVSHTKKALVPFLLDEDYEKVLGYVEADKENGENVWVAPSAPGPGPAPCTGGPKPLSPASSQDKLPPLPPLPNQEENYVTPIGDGPAVDYENQDVASSSWPVILKPKKLPKPPAKLPKPPVGPKPEPKVFNGGLGRKLPVSSAQPLFPTAGLADMTAELQKKLEKRRALEH
uniprot
proteins
function
FUNCTION: Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. {ECO:0000269|PubMed:10980601}.
uniprot
proteins
mass_dalton
44894
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="Y->F: Small decrease in tyrosine phosphorylation."; /evidence="ECO:0000269|PubMed:12540842"; MUTAGEN 250; /note="Y->F: Loss of tyrosine phosphorylation."; /evidence="ECO:0000269|PubMed:12540842"; MUTAGEN 310; /note="Y->F: Decrease in tyrosine phosphorylation."; /evidence="ECO:0000269|PubMed:12540842"; MUTAGEN 322; /note="Y->F: Decrease in tyrosine phosphorylation."; /evidence="ECO:0000269|PubMed:12540842
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC. {ECO:0000269|PubMed:12540842, ECO:0000269|PubMed:19393627}.
uniprot
proteins
pubmed
10980601
uniprot
proteins
pubmed
12540842
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19393627
uniprot
proteins
sequence_length
403
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10980601}.
uniprot
proteins