Lhfpl5
entrez
294303
canonical
uniprot
Q5PPI7
canonical
ensembl
ENSRNOG00000022283
resolver
ensembl
ENSRNOG00055007575
resolver
ensembl
ENSRNOG00060005135
resolver
ensembl
ENSRNOG00065000423
resolver
ensembl
ENSRNOG00065032952
resolver
ensp
ENSRNOP00000101314
resolver
ensp
ENSRNOP00055010072
resolver
ensp
ENSRNOP00060006406
resolver
ensp
ENSRNOP00065000536
resolver
ensp
ENSRNOP00065046669
resolver
enst
ENSRNOT00000140144
resolver
enst
ENSRNOT00055012655
resolver
enst
ENSRNOT00060008537
resolver
enst
ENSRNOT00065000631
resolver
enst
ENSRNOT00065056690
resolver
genesymbol
Lhfpl5
resolver
genesymbol_syn
Tmhs
resolver
uniprot_entry
LHPL5_RAT
resolver
amino_acid_sequence
MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVSTPQAGYFGLFSYCVGNVLSSELICKGGPLDFSSIPSRAFKTAMFFVALAMFLIIGSIICFSLFFVCNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAFMLAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGNEEV
uniprot
proteins
function
FUNCTION: Auxiliary subunit of the mechanotransducer (MET) non-specific cation channel complex located at the tips of the shorter stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. Functionally couples PCDH15 to the transduction channel. {ECO:0000250|UniProtKB:Q4KL25}.
uniprot
proteins
mass_dalton
24186
uniprot
proteins
protein_family
LHFP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q4KL25}; Multi-pass membrane protein {ECO:0000250}. Note=Efficient localization to the plasma membrane requires the presence of PCDH15. {ECO:0000250|UniProtKB:Q4KL25}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 99..119; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 129..149; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins