Pofut1
entrez
140484
canonical
uniprot
Q91ZW2
canonical
ensembl
ENSMUSG00000046020
resolver
ensp
ENSMUSP00000053122
resolver
enst
ENSMUST00000049863
resolver
genesymbol
Pofut1
resolver
uniprot
Q3V1R0
resolver
uniprot
Q8C8R4
resolver
uniprot_entry
OFUT1_MOUSE
resolver
uniprot_sec
Q3V1R0
resolver
uniprot_sec
Q8C8R4
resolver
amino_acid_sequence
MGAAAWAPPHLLLRASFLLLLLLLPLRGRSAGSWDLAGYLLYCPCMGRFGNQADHFLGSLAFAKLLNRTLAVPPWIEYQHHKPPFTNLHVSYQKYFKLEPLQAYHRVVSLEDFMENLAPSHWPPEKRVAYCFEVAAQRSPDKKTCPMKEGNPFGPFWDQFHVSFNKSELFTGISFSASYKEQWTQRFPAKEHPVLALPGAPAQFPVLEEHRELQKYMVWSDEMVRTGEALISAHLVRPYVGIHLRIGSDWKNACAMLKDGTAGSHFMASPQCVGYSRSTATPLTMTMCLPDLKEIQRAVTLWVRALNARSVYIATDSESYVSEIQQLFKDKVRVVSLKPEVAQIDLYILGQADHFIGNCVSSFTAFVKRERDLHGRQSSFFGMDRPSQLRDEF
uniprot
proteins
ec_number
2.4.1.221
uniprot
proteins
function
FUNCTION: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs). {ECO:0000269|PubMed:12697902, ECO:0000269|PubMed:18775496}.
uniprot
proteins
mass_dalton
44688
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000305|PubMed:18775496}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P83337}.
uniprot
proteins
protein_family
Glycosyltransferase 65 family
uniprot
proteins
pubmed
11524432
uniprot
proteins
pubmed
12697902
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18775496
uniprot
proteins
pubmed
19161597
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
393
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q6EV70}.
uniprot
proteins