EFNA5
entrez
1946
canonical
uniprot
P52803
canonical
ensembl
ENSG00000184349
resolver
ensp
ENSP00000328777
resolver
ensp
ENSP00000426989
resolver
enst
ENST00000333274
resolver
enst
ENST00000509503
resolver
genesymbol
EFNA5
resolver
genesymbol_syn
EPLG7
resolver
genesymbol_syn
LERK7
resolver
hgnc
HGNC:3225
resolver
uniprot
D6RDV5
resolver
uniprot_entry
D6RDV5_HUMAN
resolver
uniprot_entry
EFNA5_HUMAN
resolver
amino_acid_sequence
MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
uniprot
proteins
function
FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion. {ECO:0000269|PubMed:10601038, ECO:0000269|PubMed:11870224}.
uniprot
proteins
mass_dalton
26297
uniprot
proteins
protein_family
Ephrin family
uniprot
proteins
pubmed
10601038
uniprot
proteins
pubmed
11870224
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16239146
uniprot
proteins
pubmed
17400922
uniprot
proteins
pubmed
7748564
uniprot
proteins
pubmed
9245480
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11870224}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11870224}. Membrane, caveola {ECO:0000269|PubMed:11870224}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11870224}. Note=Compartmentalized in discrete caveolae-like membrane microdomains.
uniprot
proteins