Micu3
entrez
364601
canonical
uniprot
A0A8I6A2H6
canonical
ensembl
ENSRNOG00000012767
resolver
ensembl
ENSRNOG00055011565
resolver
ensp
ENSRNOP00000017025
resolver
ensp
ENSRNOP00000082387
resolver
ensp
ENSRNOP00000087041
resolver
ensp
ENSRNOP00000088716
resolver
ensp
ENSRNOP00055015834
resolver
ensp
ENSRNOP00055015836
resolver
ensp
ENSRNOP00055015838
resolver
ensp
ENSRNOP00055015839
resolver
enst
ENSRNOT00000017025
resolver
enst
ENSRNOT00000098345
resolver
enst
ENSRNOT00000099337
resolver
enst
ENSRNOT00000102161
resolver
enst
ENSRNOT00055019639
resolver
enst
ENSRNOT00055019641
resolver
enst
ENSRNOT00055019643
resolver
enst
ENSRNOT00055019644
resolver
genesymbol
Micu3
resolver
uniprot
A0A8I5ZTV9
resolver
uniprot
A0A8I6AA12
resolver
uniprot
A0AAK3FFS0
resolver
uniprot
A0AAK3H8H3
resolver
uniprot
A0AAK3HSM7
resolver
uniprot
D3ZG95
resolver
uniprot_entry
A0AAK3FFS0_RAT
resolver
uniprot_entry
A0AAK3H8H3_RAT
resolver
uniprot_entry
A0AAK3HSM7_RAT
resolver
uniprot_entry
MICU3_RAT
resolver
uniprot_sec
A0A8I5ZTV9
resolver
uniprot_sec
A0A8I6AA12
resolver
uniprot_sec
D3ZG95
resolver
amino_acid_sequence
MAALRRLLWPPPRLSPTLAPQQPFLSPWGRPAGTAPGMSGRPFSGREEDEGAVAEAAWRRRRWGELSIAAAAGGGLVGLVCYQLYGDPRADPSELVAPELDESPRGRGLLPIPVAAAKETVATGRAVTEDLDLYATSRERRFRLFASIECEGQLFMTPYDFILAVTTDEPKFAKTWKSLSKQELSQMLSETPPVWKGSSKLFRNLKERGVISYTEYLFLLCILTKPHAGFRIAFNMFDTDGNEMVDKKEFLVLQEIFRKKNEKRETKGDEEKRAMLRLQLYGYHSPTNSVLKPDAEELVSRSYWDTLRRSTSQALFSDLAERADDITSLVADTTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVLEIEFLSYSNGMNTISEEDFAHILLRYTNVENTSVFLENVRYSIPEEKGITFDEFRSFFQFLNNLEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKLSPHLVNTVFKIFDVDKDDQLSYKEFIGIMKDRLHRGFRGYKTVQKYPTFKSCLKKELHSR
uniprot
proteins
function
FUNCTION: Tissue-specific calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which specifically regulates MCU channel activity in the central nervous system and skeletal muscle (PubMed:31862210). Senses calcium level via its EF-hand domains: compared to MICU1 and MICU2, MICU3 has a higher affinity for calcium (PubMed:31862210). MICU1 and MICU3 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium (PubMed:31862210). At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake (PubMed:31862210). At higher calcium levels, calcium-binding to MICU1 and MICU3 induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU3 heterodimer away from the pore, allowing calcium permeation through the MCU channel (PubMed:31862210). The high calcium affinity of MICU3 lowers the calcium threshold necessary for calcium permeation through the MCU channel (PubMed:31862210). The MICU1-MICU3 heterodimer promotes flexibility of neurotransmission in neuronal cells by enhancing mitochondrial calcium uptake in presynapses (PubMed:31862210). It is also required to increase mitochondrial calcium uptake in skeletal muscle cells, thereby increasing ATP production (By similarity). {ECO:0000250|UniProtKB:Q9CTY5, ECO:0000269|PubMed:31862210}.
uniprot
proteins
mass_dalton
59842
uniprot
proteins
protein_family
MICU1 family
uniprot
proteins
protein_family
MICU3 subfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
31862210
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q8IYU8}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8IYU8}. Note=Recruited to the mitochondrial inner membrane via its association with the uniplex complex. {ECO:0000250|UniProtKB:Q8IYU8}.
uniprot
proteins