Htatsf1
entrez
72459
canonical
uniprot
Q8BGC0
canonical
ensembl
ENSMUSG00000067873
resolver
ensp
ENSMUSP00000086027
resolver
ensp
ENSMUSP00000290458
resolver
genesymbol
Htatsf1
resolver
uniprot
B1AVC7
resolver
uniprot
Q1WWK0
resolver
uniprot
Q9CT41
resolver
uniprot
Q9DAU3
resolver
uniprot_entry
HTSF1_MOUSE
resolver
uniprot_sec
B1AVC7
resolver
uniprot_sec
Q1WWK0
resolver
uniprot_sec
Q9CT41
resolver
uniprot_sec
Q9DAU3
resolver
amino_acid_sequence
MSGNNLSGNDEFDEQLRMQELYGGDPKEGDTQNEPSGEAHSLGQPPDDTPYEWDLDKKAWFPKITEDFIATYQANYGFSSDGASSSTANVQDANTKAVEEPPQKEVPETPDSKRKGEKRKAESGWFHVEEDRNTNVYVSGLPPDITVDEFIQLMSKFGIIMRDPQTEEFKVKLYKDDQGNLKGDGLCCYLKKESVELALKLLDEDEIRGYKLHVEVAKFQLKGEYDASKKKKKCKDYKKKLSLQQKQLDWRPERRAGPNRLRHERVVILKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQIRKLLLFDRHPDGVASVSFREPEEADHCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSREREERLRGWEAFLNAPEASRGLRRMDSIAGSERPGPSRMRHFSEHPSMSNMKAQEATTGMAFEETIDENKFEKAEEGGESEGDASEKDAKEGGSDGDHPEREGGEGCSKKENEEGCPERALEPEEGNPQTEAQENGPEREARKKSKMDYEKNGFSKESEDNDLGKESEGEDSLKKESEDDDSEEESEEDSSEKQSQDGSDKEIEENGVKKDVDQDVSDKEFPEDVEKESEENETDKSEFDEGSERVLDEEGSEREFEEDSDEKEEEGDDDEEEVVYERVFDDDSDDIEEEEEADEKECEDADDKEEDNDIDEKLFDDSDEKEDEEDTDGKKDDDASDKVFEDNSNEKLFDEEEGPNEKLFDDSDERGTVGNVKEDGSQSTDSSFALSSSDDDDDEV
uniprot
proteins
function
FUNCTION: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop. HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences. Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation. Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites. Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination. {ECO:0000250|UniProtKB:O43719}.
uniprot
proteins
mass_dalton
86240
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-749 by CK2 during S-phase in response to DNA damage promotes interaction with TOPBP1 and double-strand break (DSB) repair via homologous recombination. {ECO:0000250|UniProtKB:O43719}.
uniprot
proteins
protein_family
HTATSF1 family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15485897
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
757
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43719}. Chromosome {ECO:0000250|UniProtKB:O43719}. Note=Recruited to DNA damage sites during S-phase following interaction with poly-ADP-ribosylated RPA1. {ECO:0000250|UniProtKB:O43719}.
uniprot
proteins