Fkbp5
entrez
361810
canonical
uniprot
Q5U2T9
canonical
ensembl
ENSRNOG00000022523
resolver
ensembl
ENSRNOG00055007162
resolver
ensembl
ENSRNOG00060006632
resolver
ensembl
ENSRNOG00065032896
resolver
ensp
ENSRNOP00000034024
resolver
ensp
ENSRNOP00000084395
resolver
ensp
ENSRNOP00055009389
resolver
ensp
ENSRNOP00055009394
resolver
ensp
ENSRNOP00060008097
resolver
ensp
ENSRNOP00060008101
resolver
ensp
ENSRNOP00065046537
resolver
ensp
ENSRNOP00065046538
resolver
enst
ENSRNOT00055011879
resolver
enst
ENSRNOT00055011884
resolver
enst
ENSRNOT00060010885
resolver
enst
ENSRNOT00060010890
resolver
enst
ENSRNOT00065056558
resolver
enst
ENSRNOT00065056559
resolver
genesymbol
Fkbp5
resolver
genesymbol_syn
Fkbp51
resolver
uniprot
A0A8I5ZX46
resolver
uniprot
F7EYK0
resolver
uniprot_entry
FKBP5_RAT
resolver
uniprot_sec
A0A8I5ZX46
resolver
uniprot_sec
F7EYK0
resolver
amino_acid_sequence
MTTDEGTSNNEENPAATVVEQGEDITTKKDRGVLKIVKRVGTSEETPMIGDKVYVHYKGKLSNGKKFDSSRDRNEPFVFSLGKGQVIKAWDIGVSTMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGEDLFEDSGIIRRIKRKGEGYSNPNEGATVEVHLEGCCAGRVFDCRDVVFVIGEGEDHDIPIGIDKALEKMQREEQCILYLGPQYGFGEAGKPKFGIEPNAELMYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISVCQRKAKEHNERDRRVYANMFKKFAEQDAKEEASKALSKKAVEGAAGKKHESQTMGEGKAEGHV
uniprot
proteins
ec_number
5.2.1.8
uniprot
proteins
function
FUNCTION: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production. {ECO:0000250|UniProtKB:Q13451}.
uniprot
proteins
mass_dalton
50965
uniprot
proteins
post_translational_modification
PTM: Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1. Deacetylation by SIRT7 promotes interaction between Akt/AKT1 and PHLPP1, leading to suppress Akt/AKT1 activation. {ECO:0000250|UniProtKB:Q13451}.; PTM: Ubiquitinated, leading to degradation in a proteasome-dependent manner. Deubiquitinated by USP49, leading to stabilization. {ECO:0000250|UniProtKB:Q13451}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q64378}. Nucleus {ECO:0000250|UniProtKB:Q64378}.
uniprot
proteins