ENTPD1
entrez
953
canonical
uniprot
P49961
canonical
ensembl
ENSG00000138185
resolver
ensp
ENSP00000360248
resolver
ensp
ENSP00000360250
resolver
ensp
ENSP00000390955
resolver
ensp
ENSP00000442968
resolver
ensp
ENSP00000529583
resolver
ensp
ENSP00000772709
resolver
ensp
ENSP00000789131
resolver
ensp
ENSP00000795172
resolver
genesymbol
ENTPD1
resolver
genesymbol_syn
CD39
resolver
hgnc
HGNC:3363
resolver
uniprot
A9Z1X8
resolver
uniprot
B4DWB9
resolver
uniprot
B4E1X1
resolver
uniprot
B7Z599
resolver
uniprot
G3XAF6
resolver
uniprot
Q5T561
resolver
uniprot
Q5T562
resolver
uniprot
Q86VV3
resolver
uniprot
Q9UQQ9
resolver
uniprot
Q9Y3Q9
resolver
uniprot_entry
ENTP1_HUMAN
resolver
uniprot_sec
A9Z1X8
resolver
uniprot_sec
B4DWB9
resolver
uniprot_sec
B4E1X1
resolver
uniprot_sec
B7Z599
resolver
uniprot_sec
G3XAF6
resolver
uniprot_sec
Q5T561
resolver
uniprot_sec
Q5T562
resolver
uniprot_sec
Q86VV3
resolver
uniprot_sec
Q9UQQ9
resolver
uniprot_sec
Q9Y3Q9
resolver
activity_regulation
ACTIVITY REGULATION: The ADP and ATP diphosphohydrolase activities are decreased by half by sodium azide (PubMed:8529670, PubMed:8955160, PubMed:8996251). The ADP diphosphohydrolase activity is inhibited by EDTA (PubMed:8955160). The ATP and ADP diphosphohydrolase activities are inhibited by sodium fluoride (PubMed:8955160). The ADP diphosphohydrolase activity is inhibited to a less extend by adenosine 5'-[alpha,beta-methylene]triphosphate and of about 80% by AMP-PNP (PubMed:8955160). {ECO:0000269|PubMed:8529670, ECO:0000269|PubMed:8955160, ECO:0000269|PubMed:8996251}.
uniprot
proteins
amino_acid_sequence
MEDTKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFLMVLFSLVLFTVAIIGLLIFHKPSYFWKDMV
uniprot
proteins
disease_involvement
DISEASE: Spastic paraplegia 64, autosomal recessive (SPG64) [MIM:615683]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. {ECO:0000269|PubMed:24482476}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.6.1.5
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs) (Probable) (PubMed:8529670, PubMed:8626624, PubMed:8955160, PubMed:8996251). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (Probable) (PubMed:8529670, PubMed:8626624, PubMed:8955160, PubMed:8996251). This activity contributes to the regulation of extracellular levels of nucleotides (Probable) (PubMed:8529670, PubMed:8626624, PubMed:8955160, PubMed:8996251). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow (PubMed:8955160, PubMed:8996251). {ECO:0000269|PubMed:8529670, ECO:0000269|PubMed:8626624, ECO:0000269|PubMed:8955160, ECO:0000269|PubMed:8996251, ECO:0000305|PubMed:10636909}.
uniprot
proteins
mass_dalton
57965
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P97687}.; PTM: The N-terminus is blocked. {ECO:0000269|PubMed:8529670}.; PTM: Palmitoylated on Cys-13; which is required for caveola targeting. {ECO:0000269|PubMed:10636909}.
uniprot
proteins
protein_family
GDA1/CD39 NTPase family
uniprot
proteins
pubmed
10405171
uniprot
proteins
pubmed
10636909
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
24482476
uniprot
proteins
pubmed
7930580
uniprot
proteins
pubmed
8529670
uniprot
proteins
pubmed
8626624
uniprot
proteins
pubmed
8955160
uniprot
proteins
pubmed
8996251
uniprot
proteins
pubmed
9846014
uniprot
proteins
sequence_length
510
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10636909, ECO:0000269|PubMed:8955160}; Multi-pass membrane protein {ECO:0000269|PubMed:10636909}. Membrane, caveola {ECO:0000269|PubMed:10636909}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 479..499; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins