MICB
entrez
4277
canonical
uniprot
Q29980
canonical
ensembl
ENSG00000204516
resolver
ensembl
ENSG00000206449
resolver
ensembl
ENSG00000227772
resolver
ensembl
ENSG00000231179
resolver
ensembl
ENSG00000234218
resolver
ensembl
ENSG00000238289
resolver
ensp
ENSP00000252229
resolver
ensp
ENSP00000382103
resolver
ensp
ENSP00000387401
resolver
ensp
ENSP00000393355
resolver
ensp
ENSP00000398212
resolver
ensp
ENSP00000398412
resolver
ensp
ENSP00000402484
resolver
ensp
ENSP00000409414
resolver
ensp
ENSP00000442345
resolver
ensp
ENSP00000477804
resolver
enst
ENST00000428416
resolver
enst
ENST00000436531
resolver
enst
ENST00000436655
resolver
enst
ENST00000438954
resolver
enst
ENST00000442104
resolver
enst
ENST00000443156
resolver
enst
ENST00000538442
resolver
enst
ENST00000619506
resolver
genesymbol
MICB
resolver
genesymbol_syn
PERB11.2
resolver
hgnc
HGNC:7091
resolver
uniprot
A0A0G2JHB5
resolver
uniprot
A2AC57
resolver
uniprot
A6NP85
resolver
uniprot
B0UZ10
resolver
uniprot
B2RAK2
resolver
uniprot
B4DUT9
resolver
uniprot
B7Z8M1
resolver
uniprot
F5H7Q8
resolver
uniprot
O14499
resolver
uniprot
O14500
resolver
uniprot
O19798
resolver
uniprot
O19799
resolver
uniprot
O19800
resolver
uniprot
O19801
resolver
uniprot
O19802
resolver
uniprot
O19803
resolver
uniprot
O78099
resolver
uniprot
O78100
resolver
uniprot
O78101
resolver
uniprot
O78102
resolver
uniprot
O78103
resolver
uniprot
O78104
resolver
uniprot
P79525
resolver
uniprot
P79541
resolver
uniprot
Q5GR31
resolver
uniprot
Q5GR37
resolver
uniprot
Q5GR41
resolver
uniprot
Q5GR42
resolver
uniprot
Q5GR43
resolver
uniprot
Q5GR44
resolver
uniprot
Q5GR46
resolver
uniprot
Q5GR48
resolver
uniprot
Q5RIY6
resolver
uniprot
Q5SSK1
resolver
uniprot
Q5ST25
resolver
uniprot
Q7JK51
resolver
uniprot
Q7YQ89
resolver
uniprot
Q861E6
resolver
uniprot
Q9MY18
resolver
uniprot
Q9MY19
resolver
uniprot
Q9MY20
resolver
uniprot
Q9UBH4
resolver
uniprot
Q9UBZ8
resolver
uniprot
Q9UEJ0
resolver
uniprot
X6R344
resolver
uniprot_entry
A0A0G2JHB5_HUMAN
resolver
uniprot_entry
B4DUT9_HUMAN
resolver
uniprot_entry
B7Z8M1_HUMAN
resolver
uniprot_entry
F5H7Q8_HUMAN
resolver
uniprot_entry
MICB_HUMAN
resolver
uniprot_sec
A2AC57
resolver
uniprot_sec
A6NP85
resolver
uniprot_sec
B0UZ10
resolver
uniprot_sec
B2RAK2
resolver
uniprot_sec
O14499
resolver
uniprot_sec
O14500
resolver
uniprot_sec
O19798
resolver
uniprot_sec
O19799
resolver
uniprot_sec
O19800
resolver
uniprot_sec
O19801
resolver
uniprot_sec
O19802
resolver
uniprot_sec
O19803
resolver
uniprot_sec
O78099
resolver
uniprot_sec
O78100
resolver
uniprot_sec
O78101
resolver
uniprot_sec
O78102
resolver
uniprot_sec
O78103
resolver
uniprot_sec
O78104
resolver
uniprot_sec
P79525
resolver
uniprot_sec
P79541
resolver
uniprot_sec
Q5GR31
resolver
uniprot_sec
Q5GR37
resolver
uniprot_sec
Q5GR41
resolver
uniprot_sec
Q5GR42
resolver
uniprot_sec
Q5GR43
resolver
uniprot_sec
Q5GR44
resolver
uniprot_sec
Q5GR46
resolver
uniprot_sec
Q5GR48
resolver
uniprot_sec
Q5RIY6
resolver
uniprot_sec
Q5SSK1
resolver
uniprot_sec
Q5ST25
resolver
uniprot_sec
Q7JK51
resolver
uniprot_sec
Q7YQ89
resolver
uniprot_sec
Q861E6
resolver
uniprot_sec
Q9MY18
resolver
uniprot_sec
Q9MY19
resolver
uniprot_sec
Q9MY20
resolver
uniprot_sec
Q9UBH4
resolver
uniprot_sec
Q9UBZ8
resolver
uniprot_sec
Q9UEJ0
resolver
uniprot_sec
X6R344
resolver
amino_acid_sequence
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
uniprot
proteins
disease_involvement
DISEASE: Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269|PubMed:17003176}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. The MICB*004 allele is associated with rheumatoid arthritis.; DISEASE: Note=Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.
uniprot
proteins
function
FUNCTION: Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8+ alphabeta T-cells (PubMed:11491531, PubMed:11777960). Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production. {ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:9497295}.
uniprot
proteins
mass_dalton
42575
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved and released from the cell surface of tumor cells. {ECO:0000269|PubMed:16698441}.
uniprot
proteins
protein_family
MHC class I family
uniprot
proteins
protein_family
MIC subfamily
uniprot
proteins
pubmed
10359807
uniprot
proteins
pubmed
10746790
uniprot
proteins
pubmed
11239445
uniprot
proteins
pubmed
11287116
uniprot
proteins
pubmed
11491531
uniprot
proteins
pubmed
11777960
uniprot
proteins
pubmed
12133964
uniprot
proteins
pubmed
12466900
uniprot
proteins
pubmed
12538683
uniprot
proteins
pubmed
12569559
uniprot
proteins
pubmed
12782710
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15191526
uniprot
proteins
pubmed
15304008
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16698441
uniprot
proteins
pubmed
16849432
uniprot
proteins
pubmed
17003176
uniprot
proteins
pubmed
17561376
uniprot
proteins
pubmed
17565371
uniprot
proteins
pubmed
17641203
uniprot
proteins
pubmed
17678727
uniprot
proteins
pubmed
18395517
uniprot
proteins
pubmed
32153595
uniprot
proteins
pubmed
8575823
uniprot
proteins
pubmed
8952966
uniprot
proteins
pubmed
8995188
uniprot
proteins
pubmed
9271635
uniprot
proteins
pubmed
9321430
uniprot
proteins
pubmed
9497295
uniprot
proteins
pubmed
9694358
uniprot
proteins
sequence_length
383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q29983}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q29983}. Note=Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q29983, ECO:0000269|PubMed:12782710}.
uniprot
proteins
transmembrane_region
TRANSMEM 310..330; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins