Slc39a7
entrez
294281
canonical
uniprot
Q6MGB4
canonical
ensembl
ENSRNOG00000000465
resolver
ensp
ENSRNOP00000000541
resolver
genesymbol
Slc39a7
resolver
uniprot
F7EQL7
resolver
uniprot_entry
S39A7_RAT
resolver
uniprot_sec
F7EQL7
resolver
amino_acid_sequence
MARVLRDPHWVAVGLLTWAALGLLVAGHEGHGDLHRDVEEDFHGHSHGHSHEDFHHGHSHGHGHTHESIWHGHAHSHDHGHSREDVHHGHSHGHSHDSLHHRGHGHSHGASREAGAPGIKHHLDTVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGLLGDAFLHLIPHALEPHSHDTPAQPGHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGHGHAHAHGHGHSHGDSHAHGHSHAHGDRHECPSKGKPSSEDEKEAGGLRKRRGGDTGPRDGPLKPQNPEEEKTGSDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAMRLQLLTAIGALAGTACALLTEGGAVGSEVAGGAGPGWVLPFTAGGFIYVATVSVLPELLREASPLQSLLEVLGLLGGVAMMVLIAHLE
uniprot
proteins
function
FUNCTION: Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels. Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation on residues, resulting in activation of multiple downstream pathways leading to cell growth and proliferation. Has an essential role in B cell development and is required for proper B cell receptor signaling (By similarity). Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function. Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (By similarity). Has a protective role against ER stress in different biological contexts (PubMed:28232492). Mediates Zn(2+)-induced ferroptosis (By similarity). {ECO:0000250|UniProtKB:Q31125, ECO:0000250|UniProtKB:Q92504, ECO:0000269|PubMed:28232492}.
uniprot
proteins
mass_dalton
49499
uniprot
proteins
post_translational_modification
PTM: Rapidly phosphorylated by CK2 following Zn(2+) treatment. This phosphorylation is required for efficient cytosolic Zn(2+) release. {ECO:0000269|PubMed:28232492}.
uniprot
proteins
protein_family
KE4/Catsup subfamily
uniprot
proteins
protein_family
ZIP transporter (TC 2.A.5) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15060004
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28232492
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:28232492}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:28232492}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 132..152; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 208..228; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 385..405; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 409..429; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 447..467; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins