Rab3c
entrez
67295
canonical
uniprot
P62823
canonical
ensembl
ENSMUSG00000021700
resolver
ensp
ENSMUSP00000132945
resolver
ensp
ENSMUSP00000153136
resolver
ensp
ENSMUSP00000153347
resolver
enst
ENSMUST00000167824
resolver
enst
ENSMUST00000223922
resolver
enst
ENSMUST00000224180
resolver
genesymbol
Rab3c
resolver
genesymbol_syn
Rab3C
resolver
uniprot
A0A286YCT8
resolver
uniprot
A0A286YDR2
resolver
uniprot
Q542T7
resolver
uniprot
Q62858
resolver
uniprot
Q62974
resolver
uniprot
Q63482
resolver
uniprot
Q9CXQ1
resolver
uniprot
Q9CXS2
resolver
uniprot_entry
A0A286YCT8_MOUSE
resolver
uniprot_entry
A0A286YDR2_MOUSE
resolver
uniprot_entry
Q542T7_MOUSE
resolver
uniprot_entry
Q9CXS2_MOUSE
resolver
uniprot_entry
RAB3C_MOUSE
resolver
uniprot_sec
Q62858
resolver
uniprot_sec
Q62974
resolver
uniprot_sec
Q63482
resolver
uniprot_sec
Q9CXQ1
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation. {ECO:0000250|UniProtKB:P20336}.
uniprot
proteins
amino_acid_sequence
MRHEAPMQMASAQDARFGQKDSSDQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFKNEKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVILAGNKCDMEDERVVSTERGQRLGEQLGFEFFETSAKDNINVKQTFERLVDIICDKMSESLETDPAITAAKQSTRLKETPPPPQPNCGC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P10949}.
uniprot
proteins
mass_dalton
25872
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitor GDI2. {ECO:0000250|UniProtKB:Q96E17}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
12578829
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18849981
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29125462
uniprot
proteins
sequence_length
227
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
uniprot
proteins