Rab27a
entrez
11891
canonical
uniprot
Q9ERI2
canonical
ensembl
ENSMUSG00000032202
resolver
ensp
ENSMUSP00000034722
resolver
ensp
ENSMUSP00000139310
resolver
ensp
ENSMUSP00000161139
resolver
enst
ENSMUST00000034722
resolver
enst
ENSMUST00000184146
resolver
genesymbol
Rab27a
resolver
genesymbol_syn
Rab27A
resolver
genesymbol_syn
rab27a
resolver
uniprot
Q544U7
resolver
uniprot_entry
Q544U7_MOUSE
resolver
uniprot_entry
RB27A_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including DENND10, which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:P51159}.
uniprot
proteins
amino_acid_sequence
MSDGDYDYLIKFLALGDSGVGKTSVLYQYTDGKFNSKFITTVGIDFREKRVVYRANGPDGAVGRGQRIHLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYCENPDIVLCGNKSDLEDQRAVKEEEARELAEKYGIPYFETSAANGTNISHAIEMLLDLIMKRMERCVDKSWIPEGVVRSNGHTSADQLSEEKEKGLCGC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB27A regulates homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. {ECO:0000250|UniProtKB:P51159}.
uniprot
proteins
mass_dalton
25017
uniprot
proteins
mutagenesis
MUTAGEN 78; /note="Q->L: Loss of GTPase activity."; /evidence="ECO:0000269|PubMed:18940603
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated in a FBXO28-dependent manner; leading to proteasomal degradation. {ECO:0000269|PubMed:38696123}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10859366
uniprot
proteins
pubmed
11773082
uniprot
proteins
pubmed
11887186
uniprot
proteins
pubmed
12051743
uniprot
proteins
pubmed
12578829
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16716193
uniprot
proteins
pubmed
18266782
uniprot
proteins
pubmed
18354201
uniprot
proteins
pubmed
18940603
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
38696123
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P51159}; Lipid-anchor {ECO:0000250|UniProtKB:P51159}. Melanosome {ECO:0000250|UniProtKB:P51159}. Late endosome {ECO:0000250|UniProtKB:P51159}. Lysosome {ECO:0000250|UniProtKB:P51159}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles. {ECO:0000250|UniProtKB:P51159}.
uniprot
proteins