SLC10A1
entrez
6554
canonical
uniprot
Q14973
canonical
ensembl
ENSG00000100652
resolver
ensp
ENSP00000216540
resolver
enst
ENST00000216540
resolver
genesymbol
SLC10A1
resolver
genesymbol_syn
NTCP
resolver
hgnc
HGNC:10905
resolver
uniprot
B2RA41
resolver
uniprot
B9EGB6
resolver
uniprot
Q2TU29
resolver
uniprot_entry
B2RA41_HUMAN
resolver
uniprot_entry
NTCP_HUMAN
resolver
uniprot_sec
B9EGB6
resolver
uniprot_sec
Q2TU29
resolver
activity_regulation
ACTIVITY REGULATION: The transport of bile acids is sodium-dependent. {ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573}.
uniprot
proteins
amino_acid_sequence
MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKGLAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSIVMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKRPQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVLSALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA
uniprot
proteins
disease_involvement
DISEASE: Hypercholanemia, familial, 2 (FHCA2) [MIM:619256]: An autosomal recessive inborn error of metabolism characterized by persistently increased plasma levels of conjugated bile salts apparent from infancy, fat malabsorption and impaired absorption of fat-soluble vitamins, including D and K. Most patients are asymptomatic. Some neonates may have transient jaundice or transiently elevated liver enzymes. {ECO:0000269|PubMed:14660639, ECO:0000269|PubMed:24867799, ECO:0000269|PubMed:27882152, ECO:0000269|PubMed:28283843, ECO:0000269|PubMed:28835676, ECO:0000269|PubMed:29290974, ECO:0000269|PubMed:31661128, ECO:0000269|PubMed:34369070}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins (PubMed:14660639, PubMed:24867799, PubMed:34060352, PubMed:8132774). It is strictly dependent on the extracellular presence of sodium (PubMed:14660639, PubMed:24867799, PubMed:34060352, PubMed:8132774). It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:14660639, PubMed:34060352). Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321). {ECO:0000269|PubMed:14660639, ECO:0000269|PubMed:24867799, ECO:0000269|PubMed:34060352, ECO:0000269|PubMed:8132774, ECO:0000303|PubMed:33222321}.; FUNCTION: (Microbial infection) Acts as an entry receptor for hepatitis B virus (HBV) (PubMed:23150796). The recognition for human SLC10A1/NTCP is highly specific (PubMed:35545671, PubMed:35580629, PubMed:35580630, PubMed:38233573). {ECO:0000269|PubMed:23150796, ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573}.
uniprot
proteins
mass_dalton
38119
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="K->W: Disrupts interaction with HBV myristoylated pre-S1 peptide."; /evidence="ECO:0000269|PubMed:35580629"; MUTAGEN 27; /note="L->W: Disrupts interaction with HBV myristoylated pre-S1 peptide. Abolishes pre-S1-mediated attactment to HBV and the transport of bile acid; when associated with W-31. Abolishes pre-S1-mediated attactment to HBV and the transport of bile acid; when associated with W-31 and W-35."; /evidence="ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630"; MUTAGEN 31; /note="L->W: Abolishes pre-S1-mediated attactment to HBV and the transport of bile acid; when associated with W-27. Abolishes pre-S1-mediated attactment to HBV and the transport of bile acid; when associated with W-35. Abolishes pre-S1-mediated attactment to HBV and the transport of bile acid; when associated with W-27 and W-35."; /evidence="ECO:0000269|PubMed:35580630"; MUTAGEN 35; /note="L->W: Abolishes pre-S1-mediated attactment to HBV and the transport of bile acid; when associated with W-31. Abolishes pre-S1-mediated attactment to HBV and the transport of bile acid; when associated with W-27 and W-31."; /evidence="ECO:0000269|PubMed:35580630"; MUTAGEN 202; /note="V->W: Disrupts interaction with HBV myristoylated pre-S1 peptide."; /evidence="ECO:0000269|PubMed:35580629"; MUTAGEN 261; /note="Q->A: Abolishes interaction with HBV myristoylated pre-S1 peptide."; /evidence="ECO:0000269|PubMed:35580629"; MUTAGEN 263; /note="V->W: Disrupts interaction with HBV myristoylated pre-S1 peptide."; /evidence="ECO:0000269|PubMed:35580629"; MUTAGEN 264; /note="Q->A,W: Disrupts interaction with HBV myristoylated pre-S1 peptide, reduces bile acid transport and reduces HBV infection."; /evidence="ECO:0000269|PubMed:38233573"; MUTAGEN 268; /note="T->W: Disrupts interaction with HBV myristoylated pre-S1 peptide, reduces bile acid transport and reduces HBV infection."; /evidence="ECO:0000269|PubMed:38233573"; MUTAGEN 272; /note="V->W: Disrupts interaction with HBV myristoylated pre-S1 peptide, reduces bile acid transport and reduces HBV infection."; /evidence="ECO:0000269|PubMed:38233573
uniprot
proteins
protein_family
Bile acid:sodium symporter (BASS) (TC 2.A.28) family
uniprot
proteins
pubmed
11031103
uniprot
proteins
pubmed
12409283
uniprot
proteins
pubmed
14660639
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23150796
uniprot
proteins
pubmed
24867799
uniprot
proteins
pubmed
25418280
uniprot
proteins
pubmed
27882152
uniprot
proteins
pubmed
28283843
uniprot
proteins
pubmed
28835676
uniprot
proteins
pubmed
29290974
uniprot
proteins
pubmed
31661128
uniprot
proteins
pubmed
32101444
uniprot
proteins
pubmed
33222321
uniprot
proteins
pubmed
34060352
uniprot
proteins
pubmed
34369070
uniprot
proteins
pubmed
35545671
uniprot
proteins
pubmed
35580629
uniprot
proteins
pubmed
35580630
uniprot
proteins
pubmed
38233573
uniprot
proteins
pubmed
8132774
uniprot
proteins
pubmed
9458785
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14660639, ECO:0000269|PubMed:24867799}; Multi-pass membrane protein {ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..44; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY"; TRANSMEM 48..83; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY"; TRANSMEM 87..112; /note="Discontinuously helical; Name=3"; /evidence="ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY"; TRANSMEM 116..142; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY"; TRANSMEM 157..179; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY"; TRANSMEM 184..217; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY"; TRANSMEM 220..243; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY"; TRANSMEM 248..273; /note="Discontinuously helical; Name=8"; /evidence="ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY"; TRANSMEM 281..311; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY
uniprot
proteins