CYP39A1
entrez
51302
canonical
uniprot
Q9NYL5
canonical
ensembl
ENSG00000146233
resolver
ensp
ENSP00000275016
resolver
ensp
ENSP00000477769
resolver
ensp
ENSP00000559668
resolver
ensp
ENSP00000666462
resolver
ensp
ENSP00000666463
resolver
ensp
ENSP00000775580
resolver
enst
ENST00000275016
resolver
enst
ENST00000619708
resolver
genesymbol
CYP39A1
resolver
hgnc
HGNC:17449
resolver
uniprot
A0A087WTD2
resolver
uniprot
B7Z786
resolver
uniprot
Q5VTT0
resolver
uniprot
Q96FW5
resolver
uniprot_entry
A0A087WTD2_HUMAN
resolver
uniprot_entry
B7Z786_HUMAN
resolver
uniprot_entry
CP39A_HUMAN
resolver
uniprot_sec
Q5VTT0
resolver
uniprot_sec
Q96FW5
resolver
amino_acid_sequence
MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRTASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQPEGQCRIEYKQRI
uniprot
proteins
ec_number
1.14.14.26
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis (PubMed:10748047, PubMed:25201972). Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver (PubMed:10748047, PubMed:25201972). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10748047, PubMed:25201972). {ECO:0000269|PubMed:10748047, ECO:0000269|PubMed:25201972}.
uniprot
proteins
mass_dalton
54116
uniprot
proteins
pathway_participation
PATHWAY: Steroid metabolism; cholesterol degradation. {ECO:0000305|PubMed:25201972}.; PATHWAY: Lipid metabolism; bile acid biosynthesis. {ECO:0000305|PubMed:25201972}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10748047
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25201972
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q64654}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:Q64654}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 267..287; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 352..372; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 412..432; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins