Sgpl1
entrez
20397
canonical
uniprot
Q8R0X7
canonical
ensembl
ENSMUSG00000020097
resolver
ensp
ENSMUSP00000090155
resolver
ensp
ENSMUSP00000112975
resolver
ensp
ENSMUSP00000279841
resolver
ensp
ENSMUSP00000279842
resolver
enst
ENSMUST00000092498
resolver
enst
ENSMUST00000122259
resolver
genesymbol
Sgpl1
resolver
genesymbol_syn
Spl
resolver
uniprot
O54955
resolver
uniprot
Q8C942
resolver
uniprot_entry
SGPL1_MOUSE
resolver
uniprot_sec
O54955
resolver
uniprot_sec
Q8C942
resolver
amino_acid_sequence
MPGTDLLKLKDFEPYLEILESYSTKAKNYVNGYCTKYEPWQLIAWSVLCTLLIVWVYELIFQPESLWSRFKKKLFKLIRKMPFIGRKIEQQVSKAKKDLVKNMPFLKVDKDYVKTLPAQGMGTAEVLERLKEYSSMDGSWQEGKASGAVYNGEPKLTELLVQAYGEFTWSNPLHPDIFPGLRKLEAEIVRMTCSLFNGGPDSCGCVTSGGTESILMACKAYRDLALEKGIKTPEIVAPESAHAAFDKAAHYFGMKIVRVALKKNMEVDVQAMKRAISRNTAMLVCSTPQFPHGVMDPVPEVAKLAVRYKIPLHVDACLGGFLIVFMEKAGYPLEKPFDFRVKGVTSISADTHKYGYAPKGSSVVMYSNEKYRTYQFFVGADWQGGVYASPSIAGSRPGGIIAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKNIFIFGDPQLSVIALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIHFCITLVHTRKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQATIDRKLVAEISSVFLDCLYTTDPVTQGNQMNGSPKPR
uniprot
proteins
ec_number
4.1.2.27
uniprot
proteins
function
FUNCTION: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (PubMed:20097939, PubMed:9464245). Elevates stress-induced ceramide production and apoptosis (PubMed:9464245). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts (PubMed:20097939, PubMed:28262793). Involved in the regulation of pro-inflammatory response and neutrophil trafficking (PubMed:21173151). Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (PubMed:28521611). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity). {ECO:0000250|UniProtKB:Q9V7Y2, ECO:0000269|PubMed:20097939, ECO:0000269|PubMed:21173151, ECO:0000269|PubMed:28262793, ECO:0000269|PubMed:28521611, ECO:0000269|PubMed:9464245}.
uniprot
proteins
mass_dalton
63677
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:9464245}.
uniprot
proteins
protein_family
Group II decarboxylase family
uniprot
proteins
protein_family
Sphingosine-1-phosphate lyase subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15522238
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20097939
uniprot
proteins
pubmed
21173151
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28165339
uniprot
proteins
pubmed
28165343
uniprot
proteins
pubmed
28262793
uniprot
proteins
pubmed
28521611
uniprot
proteins
pubmed
9464245
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15522238, ECO:0000269|PubMed:28165339}; Single-pass type III membrane protein {ECO:0000269|PubMed:15522238}; Cytoplasmic side {ECO:0000269|PubMed:15522238}.
uniprot
proteins
transmembrane_region
TRANSMEM 41..61; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000269|PubMed:15522238
uniprot
proteins