Mef2c
entrez
17260
canonical
uniprot
Q8CFN5
canonical
ensembl
ENSMUSG00000005583
resolver
ensp
ENSMUSP00000005722
resolver
ensp
ENSMUSP00000132547
resolver
ensp
ENSMUSP00000138826
resolver
ensp
ENSMUSP00000142714
resolver
ensp
ENSMUSP00000143212
resolver
ensp
ENSMUSP00000143227
resolver
ensp
ENSMUSP00000143315
resolver
ensp
ENSMUSP00000143401
resolver
ensp
ENSMUSP00000143420
resolver
ensp
ENSMUSP00000143742
resolver
ensp
ENSMUSP00000264870
resolver
ensp
ENSMUSP00000264871
resolver
ensp
ENSMUSP00000264872
resolver
ensp
ENSMUSP00000264873
resolver
ensp
ENSMUSP00000264874
resolver
ensp
ENSMUSP00000264875
resolver
ensp
ENSMUSP00000264876
resolver
ensp
ENSMUSP00000264880
resolver
ensp
ENSMUSP00000264929
resolver
ensp
ENSMUSP00000264930
resolver
ensp
ENSMUSP00000264931
resolver
ensp
ENSMUSP00000264932
resolver
ensp
ENSMUSP00000264934
resolver
ensp
ENSMUSP00000264942
resolver
ensp
ENSMUSP00000264943
resolver
ensp
ENSMUSP00000264944
resolver
ensp
ENSMUSP00000264946
resolver
ensp
ENSMUSP00000264947
resolver
ensp
ENSMUSP00000264948
resolver
ensp
ENSMUSP00000264949
resolver
ensp
ENSMUSP00000264950
resolver
ensp
ENSMUSP00000264951
resolver
ensp
ENSMUSP00000264954
resolver
ensp
ENSMUSP00000264955
resolver
ensp
ENSMUSP00000264959
resolver
ensp
ENSMUSP00000264960
resolver
ensp
ENSMUSP00000264977
resolver
ensp
ENSMUSP00000264992
resolver
enst
ENSMUST00000005722
resolver
enst
ENSMUST00000163888
resolver
enst
ENSMUST00000199432
resolver
genesymbol
Mef2c
resolver
uniprot
A0A0G2JEC2
resolver
uniprot
A0A0H2UH28
resolver
uniprot
A0A0H2UKB6
resolver
uniprot
Q3V1B5
resolver
uniprot
Q8R0H1
resolver
uniprot
Q9D7L0
resolver
uniprot
Q9QW20
resolver
uniprot_entry
A0A0G2JEC2_MOUSE
resolver
uniprot_entry
A0A0H2UH28_MOUSE
resolver
uniprot_entry
A0A0H2UKB6_MOUSE
resolver
uniprot_entry
MEF2C_MOUSE
resolver
uniprot_entry
Q3V1B5_MOUSE
resolver
uniprot_sec
Q8R0H1
resolver
uniprot_sec
Q9D7L0
resolver
uniprot_sec
Q9QW20
resolver
amino_acid_sequence
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPSFEMPVTIPVSSHNSLVYSNPVSTLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLSIKSEPVSPPRDRTTTPSRYPQHTTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT
uniprot
proteins
function
FUNCTION: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development (PubMed:33941892). Enhances transcriptional activation mediated by SOX18 (PubMed:11554755). May also be involved in neurogenesis and in the development of cortical architecture. Isoforms that lack the repressor domain are more active than isoform 1 (By similarity). Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. {ECO:0000250|UniProtKB:Q06413, ECO:0000269|PubMed:11554755, ECO:0000269|PubMed:18086704, ECO:0000269|PubMed:18438409, ECO:0000269|PubMed:18599437, ECO:0000269|PubMed:18599438, ECO:0000269|PubMed:19211936, ECO:0000269|PubMed:33941892, ECO:0000269|PubMed:9162005, ECO:0000269|PubMed:9778514}.
uniprot
proteins
mass_dalton
51278
uniprot
proteins
mutagenesis
MUTAGEN 3; /note="R->T: Increased mobility in differentiating cells. Greatly reduced DNA binding."; /evidence="ECO:0000269|PubMed:18086704"; MUTAGEN 4; /note="K->Q: 7-fold increase in DNA binding."; /evidence="ECO:0000269|PubMed:18086704"; MUTAGEN 4; /note="K->R: Reduced acetylation by 30%. Some loss of DNA binding and transactivation activity."; /evidence="ECO:0000269|PubMed:18086704"; MUTAGEN 59..60; /note="ST->CR: Reduced DNA binding activity."; MUTAGEN 59..60; /note="ST->DD: Enhanced DNA binding activity."; MUTAGEN 59; /note="S->A: Reduced DNA binding activity."; /evidence="ECO:0000269|PubMed:8663403"; MUTAGEN 59; /note="S->D: Enhanced DNA binding activity."; /evidence="ECO:0000269|PubMed:8663403
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-59 enhances DNA binding activity (By similarity). Phosphorylation on Ser-396 is required for Lys-391 sumoylation and inhibits transcriptional activity. {ECO:0000250, ECO:0000269|PubMed:8663403}.; PTM: Acetylated by p300 on several sites in diffentiating myocytes (By similarity). Acetylation on Lys-4 increases DNA binding and transactivation. {ECO:0000250, ECO:0000269|PubMed:18086704}.; PTM: Sumoylated on Lys-391 with SUMO2 but not by SUMO1 represses transcriptional activity. {ECO:0000250}.; PTM: Proteolytically cleaved in cerebellar granule neurons, probably by caspase 7, following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
MEF2 family
uniprot
proteins
pubmed
11279209
uniprot
proteins
pubmed
11554755
uniprot
proteins
pubmed
11713257
uniprot
proteins
pubmed
15340086
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15834131
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16818234
uniprot
proteins
pubmed
18086704
uniprot
proteins
pubmed
18438409
uniprot
proteins
pubmed
18599437
uniprot
proteins
pubmed
18599438
uniprot
proteins
pubmed
19211936
uniprot
proteins
pubmed
19753306
uniprot
proteins
pubmed
20139090
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22956541
uniprot
proteins
pubmed
30409805
uniprot
proteins
pubmed
33941892
uniprot
proteins
pubmed
8506376
uniprot
proteins
pubmed
8663403
uniprot
proteins
pubmed
9013788
uniprot
proteins
pubmed
9162005
uniprot
proteins
pubmed
9778514
uniprot
proteins
sequence_length
474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11554755}. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:A0A096MJY4}.
uniprot
proteins