PLCD1
entrez
5333
canonical
uniprot
P51178
canonical
ensembl
ENSG00000187091
resolver
ensp
ENSP00000335600
resolver
ensp
ENSP00000430344
resolver
genesymbol
PLCD1
resolver
hgnc
HGNC:9060
resolver
uniprot
A0A384MR47
resolver
uniprot
A8K8F9
resolver
uniprot
B3KR14
resolver
uniprot
Q86VN8
resolver
uniprot_entry
A0A384MR47_HUMAN
resolver
uniprot_entry
A8K8F9_HUMAN
resolver
uniprot_entry
PLCD1_HUMAN
resolver
uniprot_sec
B3KR14
resolver
uniprot_sec
Q86VN8
resolver
amino_acid_sequence
MDSGRDFLTLHGLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD
uniprot
proteins
disease_involvement
DISEASE: Nail disorder, non-syndromic congenital, 3 (NDNC3) [MIM:151600]: A nail disorder characterized by a white appearance of the nail plate (true leukonychia), the nail bed (pseudoleukonychia), or neither (apparent leukonychia). Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata) or white spots (leukonychia punctata). {ECO:0000269|PubMed:21665001}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.4.11
uniprot
proteins
function
FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:15331768, PubMed:9188725). Essential for trophoblast and placental development (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (PubMed:15331768, PubMed:7890667, PubMed:9188725). {ECO:0000250|UniProtKB:Q8R3B1, ECO:0000269|PubMed:15331768, ECO:0000269|PubMed:7890667, ECO:0000269|PubMed:9188725}.
uniprot
proteins
mass_dalton
85665
uniprot
proteins
mutagenesis
MUTAGEN 327; /note="E->G: No effect on hydrolysis inositol phospholipids."; /evidence="ECO:0000269|PubMed:7890667"; MUTAGEN 338; /note="R->L: Abolishes hydrolysis inositol phospholipids. No effect on binding to phosphatidylinositol 4,5-bisphosphate."; /evidence="ECO:0000269|PubMed:7890667"; MUTAGEN 341; /note="E->G: Abolishes hydrolysis inositol phospholipids. No effect on binding to phosphatidylinositol 4,5-bisphosphate."; /evidence="ECO:0000269|PubMed:7890667"; MUTAGEN 356; /note="H->L: Abolishes hydrolysis inositol phospholipids. No effect on binding to phosphatidylinositol 4,5-bisphosphate."; /evidence="ECO:0000269|PubMed:7890667"; MUTAGEN 381; /note="S->A: Decreases hydrolysis inositol phospholipids."; /evidence="ECO:0000269|PubMed:7890667"; MUTAGEN 388; /note="S->A: No effect on hydrolysis inositol phospholipids."; /evidence="ECO:0000269|PubMed:7890667"; MUTAGEN 434; /note="K->Q: Decreases on hydrolysis inositol phospholipids."; /evidence="ECO:0000269|PubMed:7890667"; MUTAGEN 440; /note="K->Q: No effect on hydrolysis inositol phospholipids."; /evidence="ECO:0000269|PubMed:7890667"; MUTAGEN 441; /note="K->Q: Decreases on hydrolysis inositol phospholipids."; /evidence="ECO:0000269|PubMed:7890667"; MUTAGEN 549; /note="R->G: Decreases on hydrolysis inositol phospholipids."; /evidence="ECO:0000269|PubMed:7890667
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15331768
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
21665001
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7890667
uniprot
proteins
pubmed
9188725
uniprot
proteins
sequence_length
756
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15331768}; Peripheral membrane protein {ECO:0000269|PubMed:15331768}; Cytoplasmic side {ECO:0000269|PubMed:15331768}. Cytoplasm {ECO:0000269|PubMed:15331768}. Note=The membrane binding is driven by the C2 domain (By similarity). Localized predominantly to the plasma membrane because of the high affinity of the PH domain for PtdIns(4,5)P2 (PubMed:15331768). Translocation to the cytosol is a consequence of the higher affinity for Ins(1,4,5)P3 than PtdIns(4,5)P2 and therefore reflects cellular levels of Ins(1,4,5)P3 (Probable). {ECO:0000250|UniProtKB:P10688, ECO:0000269|PubMed:15331768, ECO:0000305|PubMed:15331768}.
uniprot
proteins