Rmnd5a
entrez
68477
canonical
uniprot
Q80YQ8
canonical
ensembl
ENSMUSG00000002222
resolver
ensp
ENSMUSP00000002292
resolver
enst
ENSMUST00000002292
resolver
genesymbol
Rmnd5a
resolver
uniprot
E9QNK7
resolver
uniprot
Q3TPH1
resolver
uniprot
Q3UFE2
resolver
uniprot_entry
RMD5A_MOUSE
resolver
uniprot_sec
E9QNK7
resolver
uniprot_sec
Q3TPH1
resolver
uniprot_sec
Q3UFE2
resolver
amino_acid_sequence
MDQCVTVERELEKVLHKFSGYGQLCERGLEELIDYTGGLKHEILQSHGQDAELSGTLSLVLTQCCKRIKDTVQKLASDHKDIHSSVSRVGKAIDKNFDSDISSVGIDGCWQADSQRLLNEVMVEHFFRQGMLDVAEELCQESGLSVDPSQKEPFVELNRILEALKVRVLRPALEWAVSNREMLIAQNSSLEFKLHRLYFISLLMGGTTNQREALQYAKNFQPFALNHQKDIQVLMGSLVYLRQGIENSPYVHLLDANQWADICDIFTRDACALLGLSVESPLSVSFSAGCVALPALINIKAVIEQRQCTGVWNQKDELPIEVDLGKKCWYHSIFACPILRQQTTDNNPPMKLVCGHIISRDALNKMFNGSKLKCPYCPMEQSPGDAKQIFF
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. {ECO:0000250|UniProtKB:Q9H871}.
uniprot
proteins
mass_dalton
43993
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9H871}. Cytoplasm {ECO:0000250|UniProtKB:Q9H871}.
uniprot
proteins