Slc2a4
entrez
25139
canonical
uniprot
P19357
canonical
ensembl
ENSRNOG00000017226
resolver
ensembl
ENSRNOG00055030922
resolver
ensembl
ENSRNOG00060030921
resolver
ensembl
ENSRNOG00065027449
resolver
ensp
ENSRNOP00000023256
resolver
ensp
ENSRNOP00000090027
resolver
ensp
ENSRNOP00055044410
resolver
ensp
ENSRNOP00060044618
resolver
ensp
ENSRNOP00065038886
resolver
enst
ENSRNOT00000023256
resolver
enst
ENSRNOT00055053687
resolver
enst
ENSRNOT00060053753
resolver
enst
ENSRNOT00065047400
resolver
genesymbol
Slc2a4
resolver
genesymbol_syn
Glut4
resolver
uniprot
P97900
resolver
uniprot_entry
GLUT4_RAT
resolver
uniprot_sec
P97900
resolver
amino_acid_sequence
MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGPGGPDSIPQGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWPLLLAITVLPALLQLLLLPFCPESPRYLYIIRNLEGPARKSLKRLTGWADVSDALAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFELAGVEQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPSMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISATFRRTPSLLEQEVKPSTELEYLGPDEND
uniprot
proteins
disease_involvement
DISEASE: Note=It is a candidate for certain post-receptor defects in non-insulin-dependent diabetes mellitus.
uniprot
proteins
function
FUNCTION: Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation (PubMed:2211693, PubMed:2645527, PubMed:2649253). Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells (PubMed:2211693, PubMed:2645527, PubMed:2649253). Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell (PubMed:2211693, PubMed:2645527, PubMed:2649253). {ECO:0000269|PubMed:2211693, ECO:0000269|PubMed:2645527, ECO:0000269|PubMed:2649253}.
uniprot
proteins
mass_dalton
54896
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000250|UniProtKB:P14672}.; PTM: Palmitoylated. Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane. {ECO:0000250|UniProtKB:P14672}.
uniprot
proteins
protein_family
Glucose transporter subfamily
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sugar transporter (TC 2.A.1.1) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16396496
uniprot
proteins
pubmed
1651337
uniprot
proteins
pubmed
2211693
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
26240143
uniprot
proteins
pubmed
2645527
uniprot
proteins
pubmed
2649253
uniprot
proteins
pubmed
2649883
uniprot
proteins
pubmed
7545962
uniprot
proteins
pubmed
7720644
uniprot
proteins
pubmed
9059504
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2211693}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P14142}. Endomembrane system {ECO:0000269|PubMed:26240143}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P14142}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P14142}. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (By similarity). The dileucine internalization motif is critical for intracellular sequestration (By similarity). Insulin stimulation induces translocation to the cell membrane (PubMed:2211693). {ECO:0000250|UniProtKB:P14142, ECO:0000250|UniProtKB:P14672, ECO:0000269|PubMed:2211693}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 288..308; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 324..344; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 354..374; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 385..405; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 418..438; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 446..466; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins