Taf8
entrez
63856
canonical
uniprot
Q9EQH4
canonical
ensembl
ENSMUSG00000023980
resolver
ensp
ENSMUSP00000063201
resolver
ensp
ENSMUSP00000156629
resolver
ensp
ENSMUSP00000156668
resolver
ensp
ENSMUSP00000309262
resolver
ensp
ENSMUSP00000309269
resolver
genesymbol
Taf8
resolver
genesymbol_syn
Tbn
resolver
uniprot
Q3TSE4
resolver
uniprot
Q6PES8
resolver
uniprot
Q8C382
resolver
uniprot
Q8C664
resolver
uniprot
Q8C7L7
resolver
uniprot_entry
TAF8_MOUSE
resolver
uniprot_sec
Q3TSE4
resolver
uniprot_sec
Q6PES8
resolver
uniprot_sec
Q8C382
resolver
uniprot_sec
Q8C664
resolver
uniprot_sec
Q8C7L7
resolver
amino_acid_sequence
MADTAAGPGGSGTRPGSKQSTNPADNYHLARRRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYAKRSQRMVITAPPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYIKTPTYREPVSDYQILREKAASQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARPFTIPYLTALLPSELEIQQMEETDSSEQEEQTDTENNALHISTDDSGAEKESASVLQQSSSLSGSRNGEESVIDNPYLRPVKKPKIRRKKSLS
uniprot
proteins
function
FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (By similarity). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (By similarity). TAF8 is involved in forming the TFIID-B module, together with TAF5 (By similarity). Mediates both basal and activator-dependent transcription (By similarity). Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts (PubMed:14580349). Required for the integration of TAF10 in the TAF complex (By similarity). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (PubMed:11076765). {ECO:0000250|UniProtKB:Q7Z7C8, ECO:0000269|PubMed:11076765, ECO:0000269|PubMed:14580349}.
uniprot
proteins
mass_dalton
33988
uniprot
proteins
protein_family
TAF8 family
uniprot
proteins
pubmed
11076765
uniprot
proteins
pubmed
14580349
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11076765}. Cytoplasm {ECO:0000269|PubMed:11076765}. Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell.
uniprot
proteins