FXYD5
entrez
53827
canonical
uniprot
Q96DB9
canonical
ensembl
ENSG00000089327
resolver
ensp
ENSP00000376053
resolver
ensp
ENSP00000393848
resolver
ensp
ENSP00000443390
resolver
ensp
ENSP00000444839
resolver
ensp
ENSP00000467053
resolver
ensp
ENSP00000546538
resolver
ensp
ENSP00000546541
resolver
enst
ENST00000543307
resolver
enst
ENST00000588699
resolver
genesymbol
FXYD5
resolver
genesymbol_syn
DYSAD
resolver
genesymbol_syn
IWU1
resolver
hgnc
HGNC:4029
resolver
uniprot
B7WNZ8
resolver
uniprot
F5H4X8
resolver
uniprot
Q6UW44
resolver
uniprot
Q9HC34
resolver
uniprot
Q9P039
resolver
uniprot_entry
F5H4X8_HUMAN
resolver
uniprot_entry
FXYD5_HUMAN
resolver
uniprot_sec
B7WNZ8
resolver
uniprot_sec
Q6UW44
resolver
uniprot_sec
Q9HC34
resolver
uniprot_sec
Q9P039
resolver
amino_acid_sequence
MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKAAHPTDDTTTLSERPSPSTDVQTDPQTLKPSGFHEDDPFFYDEHTLRKRGLLVAAVLFITGIIILTSGKCRQLSRLCRNRCR
uniprot
proteins
function
FUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (By similarity). May increase NKA activity by increasing the apparent affinity for Na(+) (PubMed:18263667). Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis (PubMed:11756660). {ECO:0000250|UniProtKB:P97808, ECO:0000269|PubMed:11756660, ECO:0000269|PubMed:18263667}.
uniprot
proteins
mass_dalton
19472
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:11756660}.
uniprot
proteins
protein_family
FXYD family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11342114
uniprot
proteins
pubmed
11756660
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18263667
uniprot
proteins
sequence_length
178
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11756660}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P97808}. Basolateral cell membrane {ECO:0000250|UniProtKB:P97808}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P97808}. Note=In kidneys localizes to the basolateral membrane of the connecting tubule. {ECO:0000250|UniProtKB:P97808}.
uniprot
proteins
transmembrane_region
TRANSMEM 146..164; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins