Mafa
entrez
378435
canonical
uniprot
Q8CF90
canonical
ensembl
ENSMUSG00000047591
resolver
ensp
ENSMUSP00000054226
resolver
enst
ENSMUST00000062002
resolver
genesymbol
Mafa
resolver
uniprot_entry
MAFA_MOUSE
resolver
amino_acid_sequence
MAAELAMGAELPSSPLAIEYVNDFDLMKFEVKKEPPEAERFCHRLPPGSLSSTPLSTPCSSVPSSPSFCAPSPGTGGGAGGGGSAAQAGGAPGPPSGGPGTVGGASGKAVLEDLYWMSGYQHHLNPEALNLTPEDAVEALIGSGHHGAHHGAHHPAAAAAYEAFRGQSFAGGGGADDMGAGHHHGAHHTAHHHHSAHHHHHHHHHHGGSGHHGGGAGHGGGGAGHHVRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHILESEKCQLQSQVEQLKLEVGRLAKERDLYKEKYEKLAGRGGPGGAGGAGFPREPSPAQAGPGAAKGAPDFFL
uniprot
proteins
function
FUNCTION: Transcriptional factor that activates insulin gene expression (PubMed:12368292, PubMed:15665000). Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15665000). Binds the insulin enhancer C1/RIPE3b element (PubMed:12917329, PubMed:14680841, PubMed:14973194, PubMed:15665000). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (By similarity). {ECO:0000250|UniProtKB:Q8NHW3, ECO:0000269|PubMed:12368292, ECO:0000269|PubMed:12917329, ECO:0000269|PubMed:14680841, ECO:0000269|PubMed:14973194, ECO:0000269|PubMed:15665000}.
uniprot
proteins
mass_dalton
37576
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:O57342}.; PTM: Phosphorylated at tyrosines. {ECO:0000269|PubMed:12917329}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
Maf subfamily
uniprot
proteins
pubmed
12368292
uniprot
proteins
pubmed
12917329
uniprot
proteins
pubmed
14680841
uniprot
proteins
pubmed
14973194
uniprot
proteins
pubmed
15665000
uniprot
proteins
pubmed
15923615
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12368292, ECO:0000269|PubMed:12917329, ECO:0000269|PubMed:14973194}.
uniprot
proteins