Clic3
entrez
69454
canonical
uniprot
Q9D7P7
canonical
ensembl
ENSMUSG00000015093
resolver
ensp
ENSMUSP00000109904
resolver
enst
ENSMUST00000114265
resolver
genesymbol
Clic3
resolver
uniprot_entry
CLIC3_MOUSE
resolver
amino_acid_sequence
MAETTKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRALDVLKDFAPGSQLPILLYDGDVKTDTLQIEEFLEETLGPPDFPSLAPRYRESNTAGNDIFHKFSAFIKNPVPTQDNALYQQLLRALTRLDSYLRAPLDHELAQEPHLRESHRRFLDGDQFTLADCSLLPKLHIVDTVCAHFRQLPIPAELSCVRRYLDSALQKKEFKYTCPHSAEILAAYQPAVHPR
uniprot
proteins
ec_number
1.8.-.-
uniprot
proteins
function
FUNCTION: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduced in a glutathione-dependent way and secreted into the extracellular matrix where it activates TGM2 and promotes blood vessel growth during tissue remodeling as occurs in tumorigenesis. Can reduce specific cysteines in TGM2 and regulate cofactor binding (By similarity). Can insert into membranes and form outwardly rectifying chloride ion channels. May participate in cellular growth control (By similarity). {ECO:0000250|UniProtKB:O95833}.
uniprot
proteins
mass_dalton
26846
uniprot
proteins
protein_family
Chloride channel CLIC family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95833}. Membrane {ECO:0000250|UniProtKB:O95833}; Single-pass membrane protein {ECO:0000250|UniProtKB:O95833}. Cell membrane {ECO:0000250|UniProtKB:O95833}; Single-pass membrane protein {ECO:0000250|UniProtKB:O95833}. Cytoplasm {ECO:0000250|UniProtKB:O95833}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:O95833}. Note=Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). Secreted into the extracellular matrix by activated fibroblasts (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O95833}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins