Prkacb
entrez
18749
canonical
uniprot
P68181
canonical
ensembl
ENSMUSG00000005034
resolver
ensp
ENSMUSP00000005164
resolver
ensp
ENSMUSP00000099573
resolver
ensp
ENSMUSP00000101743
resolver
ensp
ENSMUSP00000101744
resolver
genesymbol
Prkacb
resolver
genesymbol_syn
Pkacb
resolver
uniprot
P05206
resolver
uniprot
Q3TQH5
resolver
uniprot
Q3UDD0
resolver
uniprot
Q3UTH5
resolver
uniprot_entry
KAPCB_MOUSE
resolver
uniprot_sec
P05206
resolver
uniprot_sec
Q3TQH5
resolver
uniprot_sec
Q3UDD0
resolver
uniprot_sec
Q3UTH5
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cAMP. {ECO:0000250|UniProtKB:P22694}.
uniprot
proteins
amino_acid_sequence
MGNTAIAKKGSEVESVKEFLAKAKEDFLRKWENPPPSNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEEIRVSITEKCGKEFCEF
uniprot
proteins
ec_number
2.7.11.11
uniprot
proteins
function
FUNCTION: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (By similarity). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:9368018). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity). Phosphorylates GPKOW which regulates its ability to bind RNA (By similarity). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (By similarity). {ECO:0000250|UniProtKB:P22694, ECO:0000269|PubMed:9368018}.
uniprot
proteins
mass_dalton
40708
uniprot
proteins
post_translational_modification
PTM: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively. {ECO:0000250|UniProtKB:P05383}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
cAMP subfamily
uniprot
proteins
pubmed
12106288
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2833513
uniprot
proteins
pubmed
3023318
uniprot
proteins
pubmed
9368018
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P22694}. Cell membrane {ECO:0000250|UniProtKB:P22694}. Membrane {ECO:0000250|UniProtKB:P22694}; Lipid-anchor {ECO:0000250|UniProtKB:P22694}. Nucleus {ECO:0000250|UniProtKB:P05131}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. {ECO:0000250|UniProtKB:P05131}.
uniprot
proteins