EPOP
entrez
100170841
canonical
uniprot
A6NHQ4
canonical
ensembl
ENSG00000273604
resolver
ensembl
ENSG00000277303
resolver
ensp
ENSP00000483859
resolver
ensp
ENSP00000484710
resolver
enst
ENST00000613024
resolver
enst
ENST00000621654
resolver
genesymbol
EPOP
resolver
genesymbol_syn
C17orf96
resolver
genesymbol_syn
PRR28
resolver
hgnc
HGNC:34493
resolver
uniprot_entry
EPOP_HUMAN
resolver
amino_acid_sequence
METLCPAPRLAVPASPRGSPCSPTPRKPCRGTQEFSPLCLRALAFCALAKPRASSLGPGPGELAARSPVLRGPQAPLRPGGWAPDGLKHLWAPTGRPGVPNTAAGEDADVAACPRRGEEEEGGGGFPHFGVRSCAPPGRCPAPPHPRESTTSFASAPPRPAPGLEPQRGPAASPPQEPSSRPPSPPAGLSTEPAGPGTAPRPFLPGQPAEVDGNPPPAAPEAPAASPSTASPAPAAPGDLRQEHFDRLIRRSKLWCYAKGFALDTPSLRRGPERPPAKGPARGAAKKRRLPAPPPRTAQPRRPAPTLPTTSTFSLLNCFPCPPALVVGEDGDLKPASSLRLQGDSKPPPAHPLWRWQMGGPAVPEPPGLKFWGINMDES
uniprot
proteins
function
FUNCTION: Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation. {ECO:0000250|UniProtKB:Q7TNS8}.
uniprot
proteins
mass_dalton
39322
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24550272
uniprot
proteins
pubmed
29499137
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7TNS8}. Chromosome {ECO:0000250|UniProtKB:Q7TNS8}. Note=Localizes at both PRC2/EZH2 sites (H3K27me3) and broad H3K4me3 sites on chromatin of embryonic stem cells (ESCs). {ECO:0000250|UniProtKB:Q7TNS8}.
uniprot
proteins