Edem3
entrez
66967
canonical
uniprot
Q2HXL6
canonical
ensembl
ENSMUSG00000043019
resolver
ensp
ENSMUSP00000058941
resolver
ensp
ENSMUSP00000140234
resolver
ensp
ENSMUSP00000140443
resolver
ensp
ENSMUSP00000140775
resolver
ensp
ENSMUSP00000286494
resolver
ensp
ENSMUSP00000286495
resolver
ensp
ENSMUSP00000286497
resolver
ensp
ENSMUSP00000286498
resolver
ensp
ENSMUSP00000286499
resolver
ensp
ENSMUSP00000286500
resolver
ensp
ENSMUSP00000286508
resolver
enst
ENSMUST00000059498
resolver
enst
ENSMUST00000187951
resolver
enst
ENSMUST00000188145
resolver
enst
ENSMUST00000191070
resolver
genesymbol
Edem3
resolver
uniprot
A0A087WQK5
resolver
uniprot
A0A087WR24
resolver
uniprot
A0A087WRU4
resolver
uniprot
B2RS10
resolver
uniprot
B7ZNP0
resolver
uniprot
B9EHZ4
resolver
uniprot
Q6P9L0
resolver
uniprot_entry
A0A087WQK5_MOUSE
resolver
uniprot_entry
A0A087WR24_MOUSE
resolver
uniprot_entry
A0A087WRU4_MOUSE
resolver
uniprot_entry
B7ZNP0_MOUSE
resolver
uniprot_entry
EDEM3_MOUSE
resolver
uniprot_sec
B2RS10
resolver
uniprot_sec
B9EHZ4
resolver
uniprot_sec
Q6P9L0
resolver
amino_acid_sequence
MSKAGGCRGCGCRVPQRASWSLVAATAALCLVLATSVCTAGAAPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEHMQWYNDELLHMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNRSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIISHPFFGRVVLTAGPAQFGLDLSKHKETRGFVASSKPYNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIREHEQVEVLLSDKARDRDPEMENEDQPSSENDSQNQSAEQMLSLSQTVDLADKESPEHPADSHSEASPSDSEEAAGFAPSEQISGSTENHETTSLDGECTDLDNQVQEQSETEEDSSPNVSWGTKAQPIDSILADWNEDIEAFEMMEKDEL
uniprot
proteins
ec_number
3.2.1.113
uniprot
proteins
function
FUNCTION: Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD (PubMed:34143952). May have alpha 1,2-mannosidase activity. {ECO:0000250|UniProtKB:Q9BZQ6, ECO:0000269|PubMed:16431915, ECO:0000269|PubMed:34143952}.
uniprot
proteins
mass_dalton
104200
uniprot
proteins
mutagenesis
MUTAGEN 147; /note="E->Q: Loss of ERAD activity."; /evidence="ECO:0000269|PubMed:16431915
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:P32906}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated.
uniprot
proteins
protein_family
Glycosyl hydrolase 47 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16431915
uniprot
proteins
pubmed
17499246
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34143952
uniprot
proteins
sequence_length
931
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:16431915}.
uniprot
proteins