TAS2R43
entrez
259289
canonical
uniprot
P59537
canonical
ensembl
ENSG00000255374
resolver
ensembl
ENSG00000262612
resolver
ensp
ENSP00000431719
resolver
ensp
ENSP00000458723
resolver
enst
ENST00000531678
resolver
enst
ENST00000571879
resolver
genesymbol
TAS2R43
resolver
hgnc
HGNC:18875
resolver
uniprot
P59546
resolver
uniprot
Q645X4
resolver
uniprot_entry
T2R43_HUMAN
resolver
uniprot_sec
P59546
resolver
uniprot_sec
Q645X4
resolver
amino_acid_sequence
MITFLPIIFSSLVVVTFVIGNFANGFIALVNSIEWFKRQKISFADQILTALAVSRVGLLWVLLLNWYSTVLNPAFNSVEVRTTAYNIWAVINHFSNWLATTLSIFYLLKIANFSNFIFLHLKRRVKSVILVMLLGPLLFLACHLFVINMNEIVRTKEFEGNMTWKIKLKSAMYFSNMTVTMVANLVPFTLTLLSFMLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVISFLLLCAIYFLSIMISVWSFGSLENKPVFMFCKAIRFSYPSIHPFILIWGNKKLKQTFLSVFWQMRYWVKGEKTSSP
uniprot
proteins
function
FUNCTION: Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
35599
uniprot
proteins
protein_family
G protein-coupled receptor T2R family
uniprot
proteins
pubmed
11696554
uniprot
proteins
pubmed
12139982
uniprot
proteins
pubmed
12379855
uniprot
proteins
pubmed
12581520
uniprot
proteins
pubmed
12584440
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15496549
uniprot
proteins
pubmed
15537898
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
19628819
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:19628819}; Multi-pass membrane protein {ECO:0000269|PubMed:19628819}. Cell projection, cilium membrane {ECO:0000269|PubMed:19628819}. Note=In airway epithelial cells, localizes to motile cilia.
uniprot
proteins
transmembrane_region
TRANSMEM 2..22; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 47..67; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 230..250; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins