Slc35a3
entrez
229782
canonical
uniprot
Q8R1T4
canonical
ensembl
ENSMUSG00000027957
resolver
ensp
ENSMUSP00000029569
resolver
ensp
ENSMUSP00000112674
resolver
ensp
ENSMUSP00000287206
resolver
enst
ENSMUST00000029569
resolver
enst
ENSMUST00000120120
resolver
genesymbol
Slc35a3
resolver
uniprot
Q8BRW7
resolver
uniprot_entry
S35A3_MOUSE
resolver
uniprot_sec
Q8BRW7
resolver
amino_acid_sequence
MSANLKYLSLGILVFQTTSLVLTMRYSRTLKEEGPRYLSSTAVVVAEFLKIMACIFLVYKDSKCSVRALNRVLHDEILNKPMETLKLAIPSGIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVSMLGKKLGVYQWLSLVILMAGVAFVQWPSDSQELNSKDLSTGSQFVGLMAVLTACFSSGFAGVYFEKILKETKQSVWIRNIQLGFFGSIFGLMGVYVYDGELVSKNGFFQGYNQLTWIVVALQALGGLVIAAVIKYADNILKGFATSLSIILSTIISYFWLQDFVPTSVFFLGAILVIAATFLYGYDPKPAGNPTKA
uniprot
proteins
function
FUNCTION: Transports diphosphate-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into the lumen of the Golgi apparatus, functioning as an antiporter that exchanges UDP-N-acetyl-alpha-D-glucosamine for UMP (PubMed:31118275). May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate highly branched, multiantennary complex N-glycans and keratan sulfate (By similarity). However, the exact role of SLC35A3 still needs to be elucidated, it could be a member of a catalytically more efficient multiprotein complex rather than function independently as a single transporter (By similarity). {ECO:0000250|UniProtKB:Q9Y2D2, ECO:0000269|PubMed:31118275}.
uniprot
proteins
mass_dalton
35976
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="A->C: Severe impairment of UDP-GlcNAc transport activity. Does not affect membrane localization."; /evidence="ECO:0000269|PubMed:31118275"; MUTAGEN 42; /note="A->G: Severe impairment of UDP-GlcNAc transport activity."; /evidence="ECO:0000269|PubMed:31118275"; MUTAGEN 42; /note="A->V: Does not affect UDP-GlcNAc transport activity."; /evidence="ECO:0000269|PubMed:31118275"; MUTAGEN 44; /note="V->A,L,V: Increases UDP-GlcNAc transport activity."; /evidence="ECO:0000269|PubMed:31118275"; MUTAGEN 44; /note="V->C: Severe impairment of UDP-GlcNAc transport activity. Does not affect membrane localization."; /evidence="ECO:0000269|PubMed:31118275"; MUTAGEN 47; /note="E->A: Abolishes protein expression."; /evidence="ECO:0000269|PubMed:31118275"; MUTAGEN 47; /note="E->C: Severe impairment of UDP-GlcNAc transport activity. Does not affect membrane localization."; /evidence="ECO:0000269|PubMed:31118275"; MUTAGEN 47; /note="E->D: Decreases UDP-GlcNAc transport activity."; /evidence="ECO:0000269|PubMed:31118275"; MUTAGEN 47; /note="E->Q: Completely abolishes the biosynthesis of GlcNAc glycoconjugates."; /evidence="ECO:0000269|PubMed:31118275"; MUTAGEN 50; /note="K->C: Almost completely inactive UDP-GlcNAc transport activity. Does not affect membrane localization."; /evidence="ECO:0000269|PubMed:31118275"; MUTAGEN 50; /note="K->H: Abolishes protein expression."; /evidence="ECO:0000269|PubMed:31118275"; MUTAGEN 50; /note="K->R: Almost completely inactive UDP-GlcNAc transport activity."; /evidence="ECO:0000269|PubMed:31118275"; MUTAGEN 50; /note="K->R: Severe impairment of UDP-GlcNAc transport activity."; /evidence="ECO:0000269|PubMed:31118275"; MUTAGEN 180; /note="V->F: Decreases UDP-GlcNAc transport activity."; /evidence="ECO:0000269|PubMed:31118275
uniprot
proteins
post_translational_modification
PTM: O-Glcnacylation regulates the stability of SLC35A3 and the specific complex formation with MGAT4B. {ECO:0000250|UniProtKB:Q9Y2D2}.
uniprot
proteins
protein_family
Nucleotide-sugar transporter family
uniprot
proteins
protein_family
SLC35A subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
31118275
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Y2D2}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 174..194; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 212..232; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 243..263; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins