STAT5B
entrez
6777
canonical
uniprot
P51692
canonical
ensembl
ENSG00000173757
resolver
ensp
ENSP00000293328
resolver
ensp
ENSP00000398379
resolver
ensp
ENSP00000513923
resolver
ensp
ENSP00000513924
resolver
ensp
ENSP00000573636
resolver
ensp
ENSP00000621762
resolver
ensp
ENSP00000621765
resolver
ensp
ENSP00000621766
resolver
ensp
ENSP00000722876
resolver
enst
ENST00000293328
resolver
enst
ENST00000415845
resolver
enst
ENST00000698776
resolver
enst
ENST00000698777
resolver
enst
ENST00000903577
resolver
enst
ENST00000951703
resolver
enst
ENST00000951706
resolver
enst
ENST00000951707
resolver
genesymbol
STAT5B
resolver
hgnc
HGNC:11367
resolver
uniprot
Q8WWS8
resolver
uniprot_entry
STA5B_HUMAN
resolver
uniprot_sec
Q8WWS8
resolver
amino_acid_sequence
MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGGGSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS
uniprot
proteins
disease_involvement
DISEASE: Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive (GHISID1) [MIM:245590]: An autosomal recessive form of growth hormone insensitivity syndrome, a congenital disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, resistance to exogenous growth hormone therapy, and recurrent infections. Most, but not all, patients have features of immune dysregulation. {ECO:0000269|PubMed:13679528, ECO:0000269|PubMed:15827093, ECO:0000269|PubMed:22419735}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant (GHISID2) [MIM:618985]: An autosomal dominant form of growth hormone insensitivity syndrome, a congenital disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, resistance to exogenous growth hormone therapy, and recurrent infections. GHISID2 patients usually have delayed bone age, delayed puberty, and decreased serum IGF1. Some patients may have features of mild immune dysregulation, such as eczema, increased serum IgE, asthma, or celiac disease. {ECO:0000269|PubMed:29844444}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Signal transducer and transcription activator that mediates cellular responses to cytokines, hormones and growth factors (PubMed:29844444, PubMed:9188471). Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. Involved in the oncostatin-M-mediated signaling pathway through type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) (PubMed:9188471). {ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:29844444, ECO:0000269|PubMed:8732682, ECO:0000269|PubMed:9188471}.
uniprot
proteins
mass_dalton
89866
uniprot
proteins
mutagenesis
MUTAGEN 684; /note="T->A: Abolishes interaction with INSR."; /evidence="ECO:0000269|PubMed:9428692"; MUTAGEN 699; /note="Y->F: Abolishes phosphorylation by HCK."; /evidence="ECO:0000269|PubMed:12411494
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity. {ECO:0000269|PubMed:12411494, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:15121872, ECO:0000269|PubMed:17997837, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:9428692}.
uniprot
proteins
protein_family
Transcription factor STAT family
uniprot
proteins
pubmed
11773439
uniprot
proteins
pubmed
12039059
uniprot
proteins
pubmed
12411494
uniprot
proteins
pubmed
12954634
uniprot
proteins
pubmed
13679528
uniprot
proteins
pubmed
14504097
uniprot
proteins
pubmed
15121872
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15526160
uniprot
proteins
pubmed
15677474
uniprot
proteins
pubmed
15827093
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17997837
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20639532
uniprot
proteins
pubmed
20702587
uniprot
proteins
pubmed
21135090
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22419735
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24319783
uniprot
proteins
pubmed
29844444
uniprot
proteins
pubmed
8631883
uniprot
proteins
pubmed
8732682
uniprot
proteins
pubmed
9188471
uniprot
proteins
pubmed
9428692
uniprot
proteins
pubmed
9989503
uniprot
proteins
sequence_length
787
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29844444}. Nucleus {ECO:0000269|PubMed:29844444}. Note=Translocated into the nucleus in response to phosphorylation. {ECO:0000269|PubMed:29844444}.
uniprot
proteins