Edn1
entrez
13614
canonical
uniprot
P22387
canonical
ensembl
ENSMUSG00000021367
resolver
ensp
ENSMUSP00000021796
resolver
enst
ENSMUST00000021796
resolver
genesymbol
Edn1
resolver
genesymbol_syn
preproET
resolver
uniprot
P70203
resolver
uniprot
P97338
resolver
uniprot
Q544E0
resolver
uniprot_entry
EDN1_MOUSE
resolver
uniprot_entry
Q544E0_MOUSE
resolver
uniprot_sec
P70203
resolver
uniprot_sec
P97338
resolver
amino_acid_sequence
MDYFPVIFSLLFVTFQGAPETAVLGAELSTGAENGVQSPPPSTPWRPRRSKRCSCSSLMDKECVYFCHLDIIWVNTPERVVPYGLGGSSRSKRSLKDLLPNKATDQAVRCQCAHQKDKKCWNFCQAGKELRAQSTMQKSLKDSKKGKPCSKLGKKCIYQQLVEGRKLRRLEAISNSIKASFRVAKLKAELYRDQKLTHNRAH
uniprot
proteins
function
FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G protein-coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:16293765). Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (PubMed:20495147, PubMed:21525433). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (PubMed:20495147). {ECO:0000250|UniProtKB:P05305, ECO:0000250|UniProtKB:P09558, ECO:0000269|PubMed:16293765, ECO:0000269|PubMed:20495147, ECO:0000269|PubMed:21525433}.
uniprot
proteins
mass_dalton
22809
uniprot
proteins
protein_family
Endothelin/sarafotoxin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16293765
uniprot
proteins
pubmed
20495147
uniprot
proteins
pubmed
21525433
uniprot
proteins
pubmed
2768235
uniprot
proteins
pubmed
7883980
uniprot
proteins
pubmed
8238383
uniprot
proteins
pubmed
8575440
uniprot
proteins
pubmed
8688455
uniprot
proteins
pubmed
8824799
uniprot
proteins
sequence_length
202
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins