Evc2
entrez
68525
canonical
uniprot
Q8K1G2
canonical
ensembl
ENSMUSG00000050248
resolver
ensp
ENSMUSP00000055130
resolver
ensp
ENSMUSP00000227909
resolver
enst
ENSMUST00000056365
resolver
genesymbol
Evc2
resolver
genesymbol_syn
Lbn
resolver
uniprot
Q8BRF3
resolver
uniprot_entry
LBN_MOUSE
resolver
uniprot_sec
Q8BRF3
resolver
amino_acid_sequence
MGATGPTGAGGRATWVLAGNILAAALVLGSGPRALPPSFPALGPGSPSRPGPAGPWASSQYSDISREARGPFENGVIFQKCSLVSGQSESQTMHVQLSVNNTRTPTSVNLSNLLVLDEITGLAVKESPGNNTQDGIQTFRKSFLQVGECYSVSYTASLDPTALGTGESLDLPARLIFQSPSQNRTQLKAPFTITVEEKIMVLPNHGLHAAGFIAAFLISLLLTVAALFFLARGRCLQGGMLSRCRIQHPENKLEPSPFTSANGVSQDLSLNDQVVAILTSEEPGSMLQALEELEIATLNQADADLEACRNQISKDIIALLMKNLVSGGHLSPQTERKMAAAFKKQFLLLENEIQEEYERKMLALTAECDLEMRKKTENQYQREMVAMEEAEEVLKRVSERSAAECSSLLRTLHGLEQEDMQRSLTLDQAEDFAQAHRQLAVFQRNELHSIVYTQIQSAVSKGELRPEVAKMMLQDYSKTQESVEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLNTAATQLTSLIHKHERAGYLDEDQMETLLERAQTETFSIKQKLDNDLKQEKKRLHQRLITRRRRELLQKHKEQQKEQVSLGEASSTAEDAVQYLHQWRSVMAEHTAALEELQERLDQAALDDLRVLTVSLSEKATEELRRLQSTAMTQELLKRSAPWLFLQQILEEHSRESAARTTQLEAEERERGQELVQGVRQRLQQDALEAYTEEQAELRHWEHLVFMKLCCAAISLSEEDLLRVRQEAQGCFSQLDRSLALPRVRARVLQQQAQMAWREAEFRKLDQALAAPELQSKARKLRSKGRGKADLLKKNLEDKIRLFEERAPVELADQVRGELLQERVQRLEAQEAHFAESLVALQFQKVARAAETLSVYTALLSIQDLLLGELSESETLTKSACVQILESHRPELQELQELERKLEDQLVQQEEAEQQRVLESWQRWAADGPGLSEPEEMDPERQVSAILRQALNKGQKLLEQHQQRVREEWQNGAVLEDSLESIEADTMASLCSQGLRLVSYLSRMTMVPGSTLLRLLSVVLPAASQPQLLALLDAVSEKHSDHTAENESSGEQAQAEQSKRRKHQVWWKVLDSRFRADLVSQGLERMLWARQKKERILKKIYVPVQERVMFPGKGSWPHLSLEPIGELAPIPITGADAMDILNTGEKIFVFRSPREPEISLRVPPRRKKNFLNAKKANRALGLD
uniprot
proteins
function
FUNCTION: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (PubMed:21356043, PubMed:24582806). Plays a critical role in bone formation and skeletal development (PubMed:21356043). May be involved in early embryonic morphogenesis (PubMed:21356043). {ECO:0000269|PubMed:21356043, ECO:0000269|PubMed:24582806}.
uniprot
proteins
mass_dalton
137639
uniprot
proteins
mutagenesis
MUTAGEN 1185..1188; /note="FVFR->AAAA: Inhibits interaction with EFCAB7."; /evidence="ECO:0000269|PubMed:24582806
uniprot
proteins
pubmed
12136126
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21356043
uniprot
proteins
pubmed
24582806
uniprot
proteins
sequence_length
1220
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21356043}; Single-pass type I membrane protein {ECO:0000269|PubMed:21356043}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:21356043}. Cell projection, cilium {ECO:0000269|PubMed:21356043}. Cell projection, cilium membrane {ECO:0000269|PubMed:21356043, ECO:0000269|PubMed:24582806}. Nucleus {ECO:0000269|PubMed:21356043}. Note=The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner (PubMed:24582806). {ECO:0000269|PubMed:24582806}.
uniprot
proteins
transmembrane_region
TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins