Cavin4
entrez
68016
canonical
uniprot
A2AMM0
canonical
ensembl
ENSMUSG00000028348
resolver
ensp
ENSMUSP00000030033
resolver
enst
ENSMUST00000030033
resolver
genesymbol
Cavin4
resolver
genesymbol_syn
Murc
resolver
uniprot
B1PRL4
resolver
uniprot
Q5FW67
resolver
uniprot
Q9CV87
resolver
uniprot
Q9D728
resolver
uniprot_entry
CAVN4_MOUSE
resolver
uniprot_sec
B1PRL4
resolver
uniprot_sec
Q5FW67
resolver
uniprot_sec
Q9CV87
resolver
uniprot_sec
Q9D728
resolver
amino_acid_sequence
MEHNGSASNAGKIHQNRLSSVTEDEDQDAALTIVTVLDRVASVVDSVQASQKRIEERHREMGNAIKSVQIDLLKLSQSHSNTGYVVNKLFEKTRKVSAHIKDVKARVEKQQVRVTKVETKQEEIMKKNKFRVVIFQEDIPCPASLSVVKDRSLPENQEEAEEVFDPPIELSSDEEYYVEESRSARLRKSGKEHIDHIKKAFSRENMQKTRQTLDKKVSGIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKKSISSAAPSKEAFKIRSLRKAKDPKAEGQEVDRGMGVDIISGSLALGPIHEFHSDEFSETEKEVTKGGYSPQEGGDPPTPEPLKVTFKPQVRVEDDESLLLELKQSS
uniprot
proteins
function
FUNCTION: Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation (PubMed:24567387). Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (PubMed:26497963). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105). {ECO:0000269|PubMed:18332105, ECO:0000269|PubMed:24567387, ECO:0000269|PubMed:26497963}.
uniprot
proteins
mass_dalton
41008
uniprot
proteins
protein_family
CAVIN family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18332105
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19546242
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24567387
uniprot
proteins
pubmed
26497963
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:18332105}. Cytoplasm {ECO:0000269|PubMed:18332105}. Cytoplasm, cytosol {ECO:0000269|PubMed:19546242}. Membrane, caveola {ECO:0000269|PubMed:19546242, ECO:0000269|PubMed:24567387}. Cell membrane, sarcolemma {ECO:0000269|PubMed:19546242}. Cell membrane {ECO:0000269|PubMed:26497963}. Note=In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm (PubMed:18332105). Localizes in the caveolae in a caveolin-dependent manner (PubMed:19546242). {ECO:0000269|PubMed:18332105, ECO:0000269|PubMed:19546242}.
uniprot
proteins