Cbfb
entrez
12400
canonical
uniprot
Q08024
canonical
ensembl
ENSMUSG00000031885
resolver
ensp
ENSMUSP00000059382
resolver
ensp
ENSMUSP00000105019
resolver
ensp
ENSMUSP00000105021
resolver
ensp
ENSMUSP00000105022
resolver
ensp
ENSMUSP00000305455
resolver
ensp
ENSMUSP00000305456
resolver
genesymbol
Cbfb
resolver
genesymbol_syn
Pebp2b
resolver
genesymbol_syn
Pebpb2
resolver
uniprot
Q08025
resolver
uniprot
Q62050
resolver
uniprot
Q62051
resolver
uniprot
Q8C282
resolver
uniprot
Q8CGD5
resolver
uniprot_entry
PEBB_MOUSE
resolver
uniprot_sec
Q08025
resolver
uniprot_sec
Q62050
resolver
uniprot_sec
Q62051
resolver
uniprot_sec
Q8C282
resolver
uniprot_sec
Q8CGD5
resolver
amino_acid_sequence
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQTRFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLHRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEARRQQDPSPGSNLGGGDDLKLR
uniprot
proteins
function
FUNCTION: Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3) (PubMed:12434156, PubMed:8386878, PubMed:8497254). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX (PubMed:12434156, PubMed:8386878, PubMed:8497254). The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (PubMed:11257229). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development (PubMed:18258917). They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917). {ECO:0000269|PubMed:11257229, ECO:0000269|PubMed:12434156, ECO:0000269|PubMed:18258917, ECO:0000269|PubMed:8386878, ECO:0000269|PubMed:8497254}.
uniprot
proteins
mass_dalton
22030
uniprot
proteins
mutagenesis
MUTAGEN 5; /note="V->A: Interferes with heterodimerization."; /evidence="ECO:0000269|PubMed:11257229"; MUTAGEN 63; /note="N->A: Interferes with heterodimerization."; /evidence="ECO:0000269|PubMed:11257229"; MUTAGEN 104; /note="N->A: Interferes with heterodimerization."; /evidence="ECO:0000269|PubMed:11257229
uniprot
proteins
protein_family
CBF-beta family
uniprot
proteins
pubmed
10404216
uniprot
proteins
pubmed
11257229
uniprot
proteins
pubmed
11560490
uniprot
proteins
pubmed
12434156
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18258917
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22193545
uniprot
proteins
pubmed
8386878
uniprot
proteins
pubmed
8497254
uniprot
proteins
sequence_length
187
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12434156}.
uniprot
proteins