Clcn5
entrez
25749
canonical
uniprot
P51796
canonical
ensembl
ENSRNOG00000002862
resolver
ensembl
ENSRNOG00055028199
resolver
ensembl
ENSRNOG00060025939
resolver
ensembl
ENSRNOG00065011568
resolver
ensp
ENSRNOP00000100084
resolver
genesymbol
Clcn5
resolver
uniprot
A0A0G2K839
resolver
uniprot
P70642
resolver
uniprot_entry
CLCN5_RAT
resolver
uniprot_sec
A0A0G2K839
resolver
uniprot_sec
P70642
resolver
amino_acid_sequence
MAMWQGAMDNRGFHQGSFSSFQSSSSDEDLMDIPGTAMDFSMRDDVPPLDREIEGNKSYNGGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEDRDKCPEWNSWSQLIISTDQGAFAYIVNYFMYVLWALLFAFLAVSLVKAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFIVLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVVEVLIVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENHFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHHDWGIFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPMPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMANQDPESILFN
uniprot
proteins
function
FUNCTION: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). {ECO:0000250|UniProtKB:P51795, ECO:0000269|PubMed:19261613, ECO:0000305}.
uniprot
proteins
mass_dalton
90687
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation. {ECO:0000250|UniProtKB:P51795}.
uniprot
proteins
protein_family
Chloride channel (TC 2.A.49) family
uniprot
proteins
protein_family
ClC-5/CLCN5 subfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
19261613
uniprot
proteins
pubmed
8537381
uniprot
proteins
pubmed
8626585
uniprot
proteins
sequence_length
816
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:P51795}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51795}. Endosome membrane {ECO:0000250|UniProtKB:P51795}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51795}. Cell membrane {ECO:0000250|UniProtKB:P51795}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51795}.
uniprot
proteins
transmembrane_region
TRANSMEM 125..162; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 208..231; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 256..275; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 281..300; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 348..366; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 389..414; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 422..442; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 498..518; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 523..542; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 605..622; /note="Helical"; /evidence="ECO:0000250
uniprot
proteins