Plag1
entrez
56711
canonical
uniprot
Q9QYE0
canonical
ensembl
ENSMUSG00000003282
resolver
ensp
ENSMUSP00000003369
resolver
enst
ENSMUST00000003369
resolver
genesymbol
Plag1
resolver
uniprot
B1AXC4
resolver
uniprot
Q3UXC0
resolver
uniprot_entry
PLAG1_MOUSE
resolver
uniprot_sec
B1AXC4
resolver
uniprot_sec
Q3UXC0
resolver
amino_acid_sequence
MATVIPGDLSEVRDTQKAPSGKRKRGESKPRKNFPCQLCDKAFNSVEKLKVHSFSHTGERPYKCTHQDCTKAFVSKYKLQRHMATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKSYNTKLGFKRHLALHAATSGDLTCKVCLQNFESTGVLLEHLKSHAGKSSGGVKEKKHQCEHCERRFYTRKDVRRHMVVHTGRKDFLCQYCAQRFGRKDHLTRHMKKSHNQELLKVKTEPVDFLDPFTCNMSVPIKDELLPVMSLPSSELLSKPFTNTLQLNLYNTPFQSMQSSGSAHQMITTLPLGMTCPIDMDAVHPSHHLAFKCPFSSTSYAISIPEKEQPLKGEIESYLMELQGGAPSSSQDSPASSSKLGLEPQSGSPDDGAGDLSLSKSSISISDPLSTPALDFSQLFNFIPLNGPPYNPLSVGSLGMSYSQEEAHSSVSQLPTQTQDLQDPANTVGLSSLHSLSAAFTSSLSSSTTLPRFHQAFQ
uniprot
proteins
function
FUNCTION: Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Cooperates with CBFB-MYH11. {ECO:0000269|PubMed:15044690, ECO:0000269|PubMed:15930271, ECO:0000269|PubMed:16108035}.
uniprot
proteins
mass_dalton
55579
uniprot
proteins
post_translational_modification
PTM: Sumoylated with SUMO1; which inhibits transcriptional activity, but does not affect nuclear localization. Blockers of sumoylation pathway such as SENP3 and inactive UBE2I increases transcriptional capacity. Sumoylation is increased in the presence of PIAS1 (By similarity). {ECO:0000250}.; PTM: Acetylated by lysine acetyltransferase EP300; which activates transcriptional capacity. Lysine residues that are sumoylated also seem to be target for acetylation (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Krueppel C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
15044690
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15585652
uniprot
proteins
pubmed
15606491
uniprot
proteins
pubmed
15930271
uniprot
proteins
pubmed
16108035
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16193498
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Note=Strong nucleolar localization when sumoylation is inhibited. {ECO:0000250}.
uniprot
proteins