CD300LB
entrez
124599
canonical
uniprot
A8K4G0
canonical
ensembl
ENSG00000178789
resolver
ensembl
ENSG00000291919
resolver
ensp
ENSP00000376397
resolver
ensp
ENSP00000517556
resolver
ensp
ENSP00000520719
resolver
ensp
ENSP00000774401
resolver
enst
ENST00000392621
resolver
enst
ENST00000709208
resolver
enst
ENST00000718280
resolver
genesymbol
CD300LB
resolver
genesymbol_syn
CD300B
resolver
genesymbol_syn
CLM7
resolver
genesymbol_syn
CMRF35A2
resolver
genesymbol_syn
IREM3
resolver
genesymbol_syn
LMIR5
resolver
genesymbol_syn
TREM5
resolver
hgnc
HGNC:30811
resolver
uniprot
Q1EG73
resolver
uniprot
Q8IX40
resolver
uniprot
Q8N6D1
resolver
uniprot_entry
CLM7_HUMAN
resolver
uniprot_sec
Q1EG73
resolver
uniprot_sec
Q8IX40
resolver
uniprot_sec
Q8N6D1
resolver
amino_acid_sequence
MWLPPALLLLSLSGCFSIQGPESVRAPEQGSLTVQCHYKQGWETYIKWWCRGVRWDTCKILIETRGSEQGEKSDRVSIKDNQKDRTFTVTMEGLRRDDADVYWCGIERRGPDLGTQVKVIVDPEGAASTTASSPTNSNMAVFIGSHKRNHYMLLVFVKVPILLILVTAILWLKGSQRVPEEPGEQPIYMNFSEPLTKDMAT
uniprot
proteins
function
FUNCTION: Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. {ECO:0000269|PubMed:16920917, ECO:0000269|PubMed:17928527}.
uniprot
proteins
mass_dalton
22689
uniprot
proteins
mutagenesis
MUTAGEN 158; /note="K->L: Abolishes interaction with TYROBP, and strongly reduces activation properties."; /evidence="ECO:0000269|PubMed:16920917"; MUTAGEN 188; /note="Y->F: No effect on interaction with TYROBP, but strongly reduces activation properties."; /evidence="ECO:0000269|PubMed:16920917
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Tyr-188 by FYN is required for interaction with GRB2. {ECO:0000269|PubMed:16920917, ECO:0000269|PubMed:17928527}.
uniprot
proteins
protein_family
CD300 family
uniprot
proteins
pubmed
12483297
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16920917
uniprot
proteins
pubmed
17928527
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 152..172; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins