Hacl1
entrez
56794
canonical
uniprot
Q9QXE0
canonical
ensembl
ENSMUSG00000021884
resolver
ensp
ENSMUSP00000022437
resolver
ensp
ENSMUSP00000114922
resolver
enst
ENSMUST00000022437
resolver
enst
ENSMUST00000156431
resolver
genesymbol
Hacl1
resolver
genesymbol_syn
Hpcl
resolver
genesymbol_syn
Phyh2
resolver
uniprot
Q543K1
resolver
uniprot
Q9DAV1
resolver
uniprot_entry
HACL1_MOUSE
resolver
uniprot_sec
Q543K1
resolver
uniprot_sec
Q9DAV1
resolver
amino_acid_sequence
MPESNSAEGSDRSEEQVSGAKVIAQALKTQDVEYMFGVVGIPVTEIALAAQELGIKYIGMRNEQAACYAASAVGYLTGRPGVCLVVSGPGLIHALGGMANANMNCWPLIVIGGSSERNQEAMGAFQEFPQVEACRLYTKFSARPSTIELIPFIIEKAVRSSIYGRPGACYIDIPADFVTLQANVTSIKYKECCMPPPVSMAETSAVCAAASVLRDAKQPLLIIGKGAAYSHAEDSIRKLVEQCSLPFLPTPMGKGVVPDNHPNCVGAARSRALQSADVIVLFGARLNWILHFGLPPRYQADVKFIQIDICAEELGNNVRPSVILLGDIDAVSKQLLEQFDKTPWQCPPDSQWWKTLREKMKSNEAISKELASQKSLPMNYYTVFYHVQEQLPRDSFIVSEGANTMDIGRTMLQNCLPRHRLDAGSFGTMGVGLGFAIAAALVAKDRSPGQRVICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDADTWEKMLHFQEAATTVPPMCLLPNSHYEQVMTAFGGKGYFVRTPEELQHSLRQALQDTSKPCLLNIMIEPQSTRKAQDFHWLTRSNM
uniprot
proteins
ec_number
4.1.2.63
uniprot
proteins
function
FUNCTION: Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (By similarity). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (By similarity). Plays a significant role in the biosynthesis of heptadecanal in the liver (PubMed:29027957). {ECO:0000250|UniProtKB:Q9UJ83, ECO:0000269|PubMed:29027957}.
uniprot
proteins
mass_dalton
63660
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism.
uniprot
proteins
protein_family
TPP enzyme family
uniprot
proteins
pubmed
11171065
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17208939
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
28629946
uniprot
proteins
pubmed
29027957
uniprot
proteins
sequence_length
581
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:Q9UJ83}.
uniprot
proteins