Clcf1
entrez
56708
canonical
uniprot
Q9QZM3
canonical
ensembl
ENSMUSG00000040663
resolver
ensp
ENSMUSP00000045562
resolver
enst
ENSMUST00000046506
resolver
genesymbol
Clcf1
resolver
genesymbol_syn
Bsf3
resolver
genesymbol_syn
Nnt1
resolver
uniprot
Q3SXK2
resolver
uniprot
Q3TM06
resolver
uniprot_entry
CLCF1_MOUSE
resolver
uniprot_entry
Q3TM06_MOUSE
resolver
uniprot_sec
Q3SXK2
resolver
amino_acid_sequence
MDLRAGDSWGMLACLCTVLWHLPAVPALNRTGDPGPGPSIQKTYDLTRYLEHQLRSLAGTYLNYLGPPFNEPDFNPPRLGAETLPRATVNLEVWRSLNDRLRLTQNYEAYSHLLCYLRGLNRQAATAELRRSLAHFCTSLQGLLGSIAGVMATLGYPLPQPLPGTEPAWAPGPAHSDFLQKMDDFWLLKELQTWLWRSAKDFNRLKKKMQPPAASVTLHLEAHGF
uniprot
proteins
function
FUNCTION: Functions as a cytokine, either alone or by forming a stable complex with soluble CRLF1 or CNTFR. Binds to CNTFR complex (CNTFR, IL6ST/gp130, LIFR) or can signal via trans-signaling using soluble CNTFR subunits. Mechanistically, ligand binding to CNTFR, induces dimerization of the IL6ST/gp130 and LIFR, which activates JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STAT3 and to lesser extent STAT1). Moreover, CLCF1/CLF heterodimer induces tyrosine phosphorylation of PTPN11, that associates with IL6ST/gp130-LIFR, which in turn recruits PIK3 protein kinase followed by AKT protein phosphorylation. Participates in the survival of embryonic motor neurons (By similarity). Also stimulates B-cells (PubMed:10500198). {ECO:0000250|UniProtKB:Q9UBD9, ECO:0000269|PubMed:10500198}.
uniprot
proteins
mass_dalton
25261
uniprot
proteins
protein_family
IL-6 superfamily
uniprot
proteins
pubmed
10500198
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
225
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9UBD9}. Note=Secreted as a stable complex with CLCF1. Secretion is CRLF1-dependent. {ECO:0000250|UniProtKB:Q9UBD9}.
uniprot
proteins