FBXL12
entrez
54850
canonical
uniprot
Q9NXK8
canonical
ensembl
ENSG00000127452
resolver
ensp
ENSP00000247977
resolver
ensp
ENSP00000467359
resolver
ensp
ENSP00000468369
resolver
ensp
ENSP00000760358
resolver
genesymbol
FBXL12
resolver
genesymbol_syn
FBL12
resolver
hgnc
HGNC:13611
resolver
uniprot
B3KSJ8
resolver
uniprot
Q9H5K4
resolver
uniprot_entry
FXL12_HUMAN
resolver
uniprot_sec
B3KSJ8
resolver
uniprot_sec
Q9H5K4
resolver
amino_acid_sequence
MATLVELPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLYTMRPKVMWHLLRRYMASRLHSLRMGGYLFSGSQAPQLSPALLRALGQKCPNLKRLCLHVADLSMVPITSLPSTLRTLELHSCEISMAWLHKQQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDAGLQELSYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRLTVRGLSAPGLAVLEGMPALESLCLQGPLVTPEMPSPTEILSSCLTMPKLRVLELQGLGWEGQEAEKILCKGLPHCMVIVRACPKESMDWWM
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia. {ECO:0000269|PubMed:23707388}.
uniprot
proteins
mass_dalton
37026
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23707388
uniprot
proteins
sequence_length
326
uniprot
proteins