Smcr8
entrez
237782
canonical
uniprot
Q3UMB5
canonical
ensembl
ENSMUSG00000049323
resolver
ensp
ENSMUSP00000055926
resolver
ensp
ENSMUSP00000099728
resolver
genesymbol
Smcr8
resolver
uniprot
Q5U4H2
resolver
uniprot
Q8BNG6
resolver
uniprot
Q8C704
resolver
uniprot_entry
SMCR8_MOUSE
resolver
uniprot_sec
Q5U4H2
resolver
uniprot_sec
Q8BNG6
resolver
uniprot_sec
Q8C704
resolver
amino_acid_sequence
MISAPDVVAFTKEDEYEEEPYNEPALPEEYSVPLFPYASQGANPWSKLSGAKFSRDFILISEFSEQVGPQPLLTIPNDTKVFGTFDLNYFSLRIMSVDYQASFVGHPPGSAYPKLNFVEDSKVVLGDSKEGAFAYVHHLTLYDLEARGFVRPFCMAYISADQHKIMQQFQELSAEFSKASECLKMGNRKAFAGELEKKLKDLDYTRTVLHTETEIQKKANDKGFYSSQAIEKANELANVEKSIIEHQDLLRQIRSYPRQKTKIPDLQPGDTEHTQDQADQVSTTSNPEESANADLYTCRPAYTPKLIKAKSTKCFDKKLKTLEELCDTEYFTQTLAQLSHIEHMFRGDLCYLLTSQIDRVLRKQQPITNFLFEDFVEVDDRMEKQENVPSQPSQDRLPPKPVEECPIPKVLISVGSYKSSVESVLIKMEQELGDEEYTGVEATEARSFDPQENLDYLDMDMKGSISSGESIEVLGTEKSASVLSKSDSQASLTVPLSPHVVRSKAVSHRTISEDSIEVLSTCPSEALIPDDFKASYPSAINEEEAYADNEGAIHFQASAGSPEPDETQEGNLENIPSQIDSSCCIGKESEGHLVPLPTPAYTLSDEDSVVSIPPQRYIQKDQGLHVDFGVENTDPSPRDNSCEMFPAYELDPSCLLASRDVSKMSLDNYSDTTSYMGSAASTSSDRIPSAPPAGLSSERHKKRAGQNALKFIRQYPFAHPAIYSLLSGRTLVVLGEDETIVRKLVTALSIFVPNYGCYAKPVKHWISSPLHIMDFQKWKLIGLQRVASPANVGTLHTLSRYSRYTSILDLDSKTLRCPLYRGTLVPRLADHRTQIKRGSTYYLHVQSMLTQLCSKAFLYTFCHHLHLPAHSEETQEAVASRQTSFLKLNLGLVNEDIRVVQYLAELLKLHYMQESPGTTHPLLRFDYVPSFLYKI
uniprot
proteins
function
FUNCTION: Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27617292). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (By similarity). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (By similarity). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (By similarity). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (By similarity). {ECO:0000250|UniProtKB:Q8TEV9, ECO:0000269|PubMed:27617292}.
uniprot
proteins
mass_dalton
104957
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by TBK1 is required to promote autophagosome maturation. Phosphorylated by ULK1. {ECO:0000250|UniProtKB:Q8TEV9}.
uniprot
proteins
protein_family
SMCR8 family
uniprot
proteins
pubmed
11997338
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27617292
uniprot
proteins
pubmed
27875531
uniprot
proteins
pubmed
31651360
uniprot
proteins
sequence_length
935
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27617292}. Nucleus {ECO:0000250|UniProtKB:Q8TEV9}. Presynapse {ECO:0000269|PubMed:31651360}. Postsynapse {ECO:0000269|PubMed:31651360}. Note=Localizes mainly in the cytoplasm. {ECO:0000250|UniProtKB:Q8TEV9}.
uniprot
proteins