Moap1
entrez
64113
canonical
uniprot
Q9ERH6
canonical
ensembl
ENSMUSG00000096458
resolver
ensp
ENSMUSP00000133459
resolver
ensp
ENSMUSP00000137010
resolver
enst
ENSMUST00000173760
resolver
enst
ENSMUST00000178384
resolver
genesymbol
Moap1
resolver
uniprot_entry
MOAP1_MOUSE
resolver
amino_acid_sequence
MTLRLLEDWCRGMDMNPRKALLVAGIPPTCGVADIEEALQAGLAPLGEHRLLGRMFRRDENKNVALIGLTVETGSALVPKEIPAKGGVWRVIFKPPDTDSDFLCRLNEFLKGEGMTMGELTRVLGNRNDPLGLDPGIMIPEIRAPMLAQALNEALKPTLQYLRYKKLSVFSGRDPPGPGEEEFESWMFHTSQVMKTWQVSDVEKRRRLIESLRGPAFEIIRVLKINNPFITVAECLKTLETIFGIIDNPRALQVKYLTTYQKTDEKLSAYVLRLEPLLQKLVQKGAIEKEVVNQARLDQVIAGAVHKSVRRELGLPEGSPAPGLLQLLTLIKDKEAEEEEVLLQAELEGYCT
uniprot
proteins
function
FUNCTION: Retrotransposon-derived protein that forms virion-like capsids (PubMed:34413232). Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis (By similarity). Required for death receptor-dependent apoptosis (By similarity). When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (By similarity). Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins (PubMed:33783314). Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex (By similarity). {ECO:0000250|UniProtKB:Q96BY2, ECO:0000269|PubMed:33783314, ECO:0000269|PubMed:34413232}.
uniprot
proteins
mass_dalton
39404
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39. {ECO:0000250|UniProtKB:Q96BY2}.
uniprot
proteins
protein_family
PNMA family
uniprot
proteins
pubmed
11060313
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17404571
uniprot
proteins
pubmed
19366867
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33783314
uniprot
proteins
pubmed
34413232
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q96BY2}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q96BY2}. Extracellular vesicle membrane {ECO:0000269|PubMed:34413232}. Note=Forms virion-like extracellular vesicles that are released from cells. {ECO:0000269|PubMed:34413232}.
uniprot
proteins