Il17c
entrez
234836
canonical
uniprot
Q8K4C5
canonical
ensembl
ENSMUSG00000046108
resolver
ensp
ENSMUSP00000056008
resolver
enst
ENSMUST00000050963
resolver
genesymbol
Il17c
resolver
uniprot
A0A0R4J0P4
resolver
uniprot
A6H6F0
resolver
uniprot_entry
A0A0R4J0P4_MOUSE
resolver
uniprot_entry
IL17C_MOUSE
resolver
uniprot_sec
A6H6F0
resolver
amino_acid_sequence
MSLLLLGWLPTGMTHQDPPSWGKPRSHRTLRCYSAEELSHGQAPPHLLTRSARWEQALPVALVASLEATGHRRQHEGPLAGTQCPVLRPEEVLEADTHERSISPWRYRIDTDENRYPQKLAVAECLCRGCINAKTGRETAALNSVQLLQSLLVLRRQPCSRDGTADPTPGSFAFHTEFIRVPVGCTCVLPRSTQ
uniprot
proteins
function
FUNCTION: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and pro-inflammatory molecules for host defense by signaling through the NFKB and MAPK pathways. Acts synergically with IL22, TNF and IL1B in inducing antibacterial peptides. May have protective function by maintaining epithelial homeostasis after an inflammatory challenge, such as that caused in the intestine by dextran sulfate sodium in a colitis model. May also promote an inflammatory phenotype, such as skin in a psoriasis model. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases, such as autoimmune encephalitis. {ECO:0000269|PubMed:21982598, ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:21993849}.
uniprot
proteins
mass_dalton
21592
uniprot
proteins
protein_family
IL-17 family
uniprot
proteins
pubmed
12077275
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21982598
uniprot
proteins
pubmed
21993848
uniprot
proteins
pubmed
21993849
uniprot
proteins
sequence_length
194
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins