PDCD4
entrez
27250
canonical
uniprot
Q53EL6
canonical
ensembl
ENSG00000150593
resolver
ensp
ENSP00000280154
resolver
ensp
ENSP00000376816
resolver
ensp
ENSP00000589493
resolver
genesymbol
PDCD4
resolver
genesymbol_syn
H731
resolver
hgnc
HGNC:8763
resolver
uniprot
B2RCV4
resolver
uniprot
B4DKX4
resolver
uniprot
B5ME91
resolver
uniprot
O15501
resolver
uniprot
Q5VZS6
resolver
uniprot
Q6PJI5
resolver
uniprot
Q8TAR5
resolver
uniprot
Q99834
resolver
uniprot_entry
B4DKX4_HUMAN
resolver
uniprot_entry
PDCD4_HUMAN
resolver
uniprot_sec
B2RCV4
resolver
uniprot_sec
B5ME91
resolver
uniprot_sec
O15501
resolver
uniprot_sec
Q5VZS6
resolver
uniprot_sec
Q6PJI5
resolver
uniprot_sec
Q8TAR5
resolver
uniprot_sec
Q99834
resolver
amino_acid_sequence
MDVENEQILNVNPADPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAKRRLRKNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY
uniprot
proteins
function
FUNCTION: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}.
uniprot
proteins
mass_dalton
51735
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="S->A: Loss of phosphorylation site. Reduces interaction with BTRC. Abolishes phosphorylation by PKB; when associated with A-457."; /evidence="ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:17053147"; MUTAGEN 71; /note="S->A: Strongly reduced interaction with BTRC. Strongly reduced ubiquitination."; /evidence="ECO:0000269|PubMed:17053147"; MUTAGEN 76; /note="S->A: Strongly reduced interaction with BTRC. Strongly reduced ubiquitination."; /evidence="ECO:0000269|PubMed:17053147"; MUTAGEN 174; /note="E->A: Reduced inhibition of EIF4A1 helicase activity."; /evidence="ECO:0000269|PubMed:19153607"; MUTAGEN 210; /note="E->A: Reduced inhibition of EIF4A1 helicase activity. Strongly reduced inhibition of translation."; /evidence="ECO:0000269|PubMed:19153607"; MUTAGEN 249; /note="E->A: Reduced interaction with EIF4A1."; /evidence="ECO:0000269|PubMed:19153607"; MUTAGEN 252; /note="L->A: Strongly reduced interaction with EIF4A1. Reduced inhibition of EIF4A1 helicase activity. Strongly reduced inhibition of translation."; /evidence="ECO:0000269|PubMed:19153607"; MUTAGEN 253; /note="D->A: Strongly reduced interaction with EIF4A1. Strongly reduced inhibition of translation. Reduced inhibition of EIF4A1 helicase activity."; /evidence="ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291"; MUTAGEN 255; /note="P->A: Reduced inhibition of EIF4A1 helicase activity. Strongly reduced inhibition of translation."; /evidence="ECO:0000269|PubMed:19153607"; MUTAGEN 333; /note="M->A: No effect on inhibition of EIF4A1 and on inhibition of translation; when associated with A-340."; /evidence="ECO:0000269|PubMed:19204291"; MUTAGEN 337; /note="E->A: No effect on inhibition of EIF4A1 and on inhibition of translation."; /evidence="ECO:0000269|PubMed:19204291"; MUTAGEN 340; /note="L->A: No effect on inhibition of EIF4A1 and on inhibition of translation; when associated with A-333."; /evidence="ECO:0000269|PubMed:19204291"; MUTAGEN 358; /note="H->A: Strongly reduced interaction with EIF4A1."; /evidence="ECO:0000269|PubMed:19153607"; MUTAGEN 359; /note="F->A: Strongly reduced inhibition of EIF4A1. Strongly reduced inhibition of translation."; /evidence="ECO:0000269|PubMed:19204291"; MUTAGEN 361; /note="H->A: Strongly reduced inhibition of EIF4A1. Strongly reduced inhibition of translation."; /evidence="ECO:0000269|PubMed:19204291"; MUTAGEN 414; /note="D->A: Strongly reduced interaction with EIF4A1. Strongly reduced inhibition of translation."; /evidence="ECO:0000269|PubMed:19153607"; MUTAGEN 418; /note="D->A: Reduced interaction with EIF4A1. Strongly reduced inhibition of translation."; /evidence="ECO:0000269|PubMed:19153607"; MUTAGEN 420; /note="P->A: Strongly reduced interaction with EIF4A1. Strongly reduced inhibition of translation."; /evidence="ECO:0000269|PubMed:19153607"; MUTAGEN 457; /note="S->A: Loss of phosphorylation site, and loss of nuclear accumulation. Abolishes phosphorylation by PKB; when associated with A-67."; /evidence="ECO:0000269|PubMed:16357133
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation. {ECO:0000269|PubMed:17053147}.; PTM: Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4. {ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:17053147}.
uniprot
proteins
protein_family
PDCD4 family
uniprot
proteins
pubmed
10632927
uniprot
proteins
pubmed
12898601
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16357133
uniprot
proteins
pubmed
16449643
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17053147
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18296639
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19153607
uniprot
proteins
pubmed
19204291
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9759869
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61823}. Cytoplasm {ECO:0000250|UniProtKB:Q61823}. Note=Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133). {ECO:0000269|PubMed:16357133}.
uniprot
proteins