Snrpd1
entrez
20641
canonical
uniprot
P62315
canonical
ensembl
ENSMUSG00000002477
resolver
ensp
ENSMUSP00000002551
resolver
enst
ENSMUST00000002551
resolver
genesymbol
Snrpd1
resolver
uniprot
P13641
resolver
uniprot
Q3UYM0
resolver
uniprot_entry
SMD1_MOUSE
resolver
uniprot_sec
P13641
resolver
uniprot_sec
Q3UYM0
resolver
amino_acid_sequence
MKLVRFLMKLSHETVTIELKNGTQVHGTITGVDVSMNTHLKAVKMTLKNREPVQLETLSIRGNNIRYFILPDSLPLDTLLVDVEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR
uniprot
proteins
function
FUNCTION: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. {ECO:0000250|UniProtKB:P62314}.
uniprot
proteins
mass_dalton
13282
uniprot
proteins
post_translational_modification
PTM: Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs. {ECO:0000250|UniProtKB:P62314}.
uniprot
proteins
protein_family
SnRNP core protein family
uniprot
proteins
pubmed
1388635
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
119
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P62314}. Nucleus {ECO:0000250|UniProtKB:P62314}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000250|UniProtKB:P62314}.
uniprot
proteins