SPCS1
entrez
28972
canonical
uniprot
Q9Y6A9
canonical
ensembl
ENSG00000114902
resolver
ensp
ENSP00000233025
resolver
ensp
ENSP00000478310
resolver
enst
ENST00000233025
resolver
enst
ENST00000619898
resolver
genesymbol
SPCS1
resolver
genesymbol_syn
SPC12
resolver
hgnc
HGNC:23401
resolver
uniprot
A0A5F9YFS9
resolver
uniprot
B3KNF8
resolver
uniprot
Q9BVW1
resolver
uniprot
X6R2S6
resolver
uniprot_entry
A0A5F9YFS9_HUMAN
resolver
uniprot_entry
SPCS1_HUMAN
resolver
uniprot_sec
B3KNF8
resolver
uniprot_sec
Q9BVW1
resolver
uniprot_sec
X6R2S6
resolver
amino_acid_sequence
MARGGDTGCTGPSETSASGAAAIALPGLEGPATDAQCQTLPLTVLKSRSPSPRSLPPALSCPPPQPAMLEHLSSLPTQMDYKGQKLAEQMFQGIILFSAIVGFIYGYVAEQFGWTVYIVMAGFAFSCLLTLPPWPIYRRHPLKWLPVQESSTDDKKPGERKIKRHAKNN
uniprot
proteins
function
FUNCTION: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Dispensable for SPC enzymatic activity (By similarity). {ECO:0000250|UniProtKB:P46965, ECO:0000269|PubMed:34388369}.; FUNCTION: (Microbial infection) Required for the post-translational processing of proteins involved in virion assembly and secretion from flaviviruses such as West Nile virus (WNV), Japanese encephalitis virus (JEV), Dengue virus type 2 (DENV-2), Yellow Fever virus (YFV), Zika virus (ZIKV) and hepatitis C virus (HCV) (PubMed:24009510, PubMed:27383988, PubMed:29593046). Plays a key role in the post-translational processing of flaviviral structural proteins prM, E, and NS1 (PubMed:27383988, PubMed:29593046). In HCV, it is involved in virion assembly where it promotes the interaction between HCV virus proteins NS2 and E2 (PubMed:24009510). {ECO:0000269|PubMed:24009510, ECO:0000269|PubMed:27383988, ECO:0000269|PubMed:29593046}.
uniprot
proteins
mass_dalton
18298
uniprot
proteins
post_translational_modification
PTM: May be phosphorylated. {ECO:0000269|PubMed:34388369}.
uniprot
proteins
protein_family
SPCS1 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24009510
uniprot
proteins
pubmed
24023390
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27383988
uniprot
proteins
pubmed
29593046
uniprot
proteins
pubmed
34388369
uniprot
proteins
pubmed
8632014
uniprot
proteins
sequence_length
169
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P83362}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P83362}.
uniprot
proteins
transmembrane_region
TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins