Ptdss2
entrez
27388
canonical
uniprot
Q9Z1X2
canonical
ensembl
ENSMUSG00000025495
resolver
ensp
ENSMUSP00000026568
resolver
ensp
ENSMUSP00000259792
resolver
genesymbol
Ptdss2
resolver
genesymbol_syn
Pss2
resolver
uniprot
Q8BHL2
resolver
uniprot
Q8CCI8
resolver
uniprot
Q8CCY7
resolver
uniprot
Q922A1
resolver
uniprot
Q9CY68
resolver
uniprot_entry
PTSS2_MOUSE
resolver
uniprot_sec
Q8BHL2
resolver
uniprot_sec
Q8CCI8
resolver
uniprot_sec
Q8CCY7
resolver
uniprot_sec
Q922A1
resolver
uniprot_sec
Q9CY68
resolver
activity_regulation
ACTIVITY REGULATION: Almost complete inhibition by ethanolamine in both the mitochondria-associated membrane (MAM) and endoplasmic reticulum (ER) per se. {ECO:0000269|PubMed:10938271}.
uniprot
proteins
amino_acid_sequence
MRRGERRVAGGSGSESPLLKGRRSTESEVYDDGTNTFFWRAHTLTVLFILTCALGYVTLLEETPQDTAYNTKRGIVASILVFLCFGVTQAKDGPFSRPHPAYWRFWLCVSVVYELFLIFILFQTVQDGRQFLKYVDPRLGVPLPERDYGGNCLIYDADNKTDPFHNIWDKLDGFVPAHFIGWYLKTLMIRDWWMCMIISVMFEFLEYSLEHQLPNFSECWWDHWIMDVLVCNGLGIYCGMKTLEWLSLKTYKWQGLWNIPTYKGKMKRIAFQFTPYSWVRFEWKPASSLHRWLAVCGIILVFLLAELNTFYLKFVLWMPPEHYLVLLRLVFFVNVGGVAMREIYDFMDELKPHRKLGQQAWLVAAITVTELLIVVKYDPHTLTLSLPFYISQCWTLGSILVLTWTVWRFFLRDITMRYKETRRQKQQSHQARAVNNRDGHPGPDDDLLGTGTAEEEGTTNDGVTAEEGTSAAS
uniprot
proteins
ec_number
2.7.8.29
uniprot
proteins
function
FUNCTION: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine to form phosphatidylserine (PubMed:10432300, PubMed:10938271, PubMed:12361952, PubMed:23071296). Lacks phosphatidylcholine-dependent base-exchange activity (PubMed:10432300, PubMed:10938271, PubMed:12361952, PubMed:23071296). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (PubMed:23071296). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (PubMed:23071296). {ECO:0000269|PubMed:10432300, ECO:0000269|PubMed:10938271, ECO:0000269|PubMed:12361952, ECO:0000269|PubMed:23071296}.
uniprot
proteins
mass_dalton
55021
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylserine biosynthesis.
uniprot
proteins
protein_family
Phosphatidyl serine synthase family
uniprot
proteins
pubmed
10432300
uniprot
proteins
pubmed
10938271
uniprot
proteins
pubmed
12361952
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18343815
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23071296
uniprot
proteins
sequence_length
473
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10938271}; Multi-pass membrane protein {ECO:0000269|PubMed:10938271}. Membrane {ECO:0000269|PubMed:23071296}. Note=Highly enriched in the mitochondria-associated membrane (MAM).
uniprot
proteins
transmembrane_region
TRANSMEM 41..61; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 75..95; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 292..312; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 314..334; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 355..375; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 382..402; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins