Scyl2
entrez
213326
canonical
uniprot
Q8CFE4
canonical
ensembl
ENSMUSG00000069539
resolver
ensp
ENSMUSP00000089874
resolver
ensp
ENSMUSP00000133992
resolver
ensp
ENSMUSP00000329072
resolver
enst
ENSMUST00000092227
resolver
genesymbol
Scyl2
resolver
genesymbol_syn
Cvak104
resolver
genesymbol_syn
D10Ertd802e
resolver
uniprot
G5E8J9
resolver
uniprot
Q3UT57
resolver
uniprot
Q3UWU9
resolver
uniprot
Q8K0M4
resolver
uniprot_entry
G5E8J9_MOUSE
resolver
uniprot_entry
SCYL2_MOUSE
resolver
uniprot_sec
Q3UT57
resolver
uniprot_sec
Q3UWU9
resolver
uniprot_sec
Q8K0M4
resolver
amino_acid_sequence
MESMLNKLKSTVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSSISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNVTPENVILNKSGAWKIMGFDFCVSSSNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGAVMYAVFNQGRPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTSIPEEVREHVKLLLNVTPTVRPDADQMTKIPFFDDVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSEFVNPDMVPFVLPNVLLIAEECTKEEYIKLILPELGPVFKQQEPIQILLIFLQKMDLLLTKTPPDEIKNSVLPMVYRALEAPSIQIQELCLNIIPTFANLIDYPSMKNALIPRIKNACLQTSSLAVRVNSLVCLGKILEYLDKWFVLDDILPFLQQIPSKEPAVLMGILGIYKCTFTHKKLGITKEQLAGKVLPHLIPLSIENNLNLNQFSSFIAVIKEMLSRLESEHRTKLEQLHVMQEQQRSLDIGNQMSTSEETKVAHSGSQQIDKVFNNIGADLLSGSESENREDGMQGKQKRGSLTLEEKQKLAKEQEQAQKLKSQQPLKPQVHTPIAPIKQTKDLTDTLMENMSSLTSLSVSTPKISASSTFTPVPSTGLGMMFSTPIDNTKRNLTNGLNANMGFQTSGFSMPVNPNQNFFSGTGTAGVTTMSLGAPPTMSNFSPLTIPPASVKQPQQRPTDMSALNNLFGPQKPKVSMNQLSQQKPNQWLNQFAPPQGSPVMGSAAMGTQGNVMGQAAFGMQGNPFFNPQNFAQPPPTTMTSSSSASNDLKDLFG
uniprot
proteins
function
FUNCTION: Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system. A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed (By similarity). By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (PubMed:26203146). {ECO:0000250|UniProtKB:Q6P3W7, ECO:0000269|PubMed:26203146}.
uniprot
proteins
mass_dalton
103317
uniprot
proteins
post_translational_modification
PTM: Could autophosphorylate in presence of poly-L-lysine. {ECO:0000250|UniProtKB:Q6P3W7}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16914521
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26203146
uniprot
proteins
sequence_length
930
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q6P3W7}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q6P3W7}. Endosome membrane {ECO:0000250|UniProtKB:Q6P3W7}. Note=Colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes. {ECO:0000250|UniProtKB:Q6P3W7}.
uniprot
proteins