CYP2C18
entrez
1562
canonical
uniprot
P33260
canonical
ensembl
ENSG00000108242
resolver
ensp
ENSP00000285979
resolver
ensp
ENSP00000341293
resolver
genesymbol
CYP2C18
resolver
hgnc
HGNC:2620
resolver
uniprot
B2R8K2
resolver
uniprot
Q16703
resolver
uniprot
Q16751
resolver
uniprot
Q4VAT5
resolver
uniprot
Q6GRG1
resolver
uniprot_entry
CP2CI_HUMAN
resolver
uniprot_sec
B2R8K2
resolver
uniprot_sec
Q16703
resolver
uniprot_sec
Q16751
resolver
uniprot_sec
Q4VAT5
resolver
uniprot_sec
Q6GRG1
resolver
amino_acid_sequence
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIPV
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). {ECO:0000269|PubMed:11093772}.
uniprot
proteins
mass_dalton
55711
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000269|PubMed:11093772}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
11093772
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16963442
uniprot
proteins
pubmed
2009263
uniprot
proteins
pubmed
8095407
uniprot
proteins
pubmed
8333835
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11093772}; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:11093772}; Peripheral membrane protein.
uniprot
proteins