MRPL41
entrez
64975
canonical
uniprot
Q8IXM3
canonical
ensembl
ENSG00000182154
resolver
ensp
ENSP00000360498
resolver
enst
ENST00000371443
resolver
genesymbol
MRPL41
resolver
genesymbol_syn
BMRP
resolver
genesymbol_syn
MRPL27
resolver
genesymbol_syn
RPML27
resolver
hgnc
HGNC:14492
resolver
uniprot
Q96Q49
resolver
uniprot_entry
RM41_HUMAN
resolver
uniprot_sec
Q96Q49
resolver
amino_acid_sequence
MGVLAAAARCLVRGADRMSKWTSKRGPRSFRGRKGRGAKGIGFLTSGWRFVQIKEMVPEFVVPDLTGFKLKPYVSYLAPESEETPLTAAQLFSEAVAPAIEKDFKDGTFDPDNLEKYGFEPTQEGKLFQLYPRNFLR
uniprot
proteins
function
FUNCTION: Component of the mitochondrial ribosome large subunit (PubMed:25278503, PubMed:25838379, PubMed:28892042, PubMed:35177605). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796). {ECO:0000269|PubMed:16024796, ECO:0000269|PubMed:16256947, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042, ECO:0000269|PubMed:35177605}.
uniprot
proteins
mass_dalton
15383
uniprot
proteins
protein_family
Mitochondrion-specific ribosomal protein mL41 family
uniprot
proteins
pubmed
11543634
uniprot
proteins
pubmed
11551941
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15547950
uniprot
proteins
pubmed
16024796
uniprot
proteins
pubmed
16256947
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25278503
uniprot
proteins
pubmed
25838379
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28892042
uniprot
proteins
pubmed
35177605
uniprot
proteins
sequence_length
137
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16024796, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
uniprot
proteins