Tmem106a
entrez
217203
canonical
uniprot
Q8VC04
canonical
ensembl
ENSMUSG00000034947
resolver
ensp
ENSMUSP00000045832
resolver
ensp
ENSMUSP00000097971
resolver
ensp
ENSMUSP00000191015
resolver
enst
ENSMUST00000039581
resolver
enst
ENSMUST00000100403
resolver
genesymbol
Tmem106a
resolver
uniprot
Q3U4J0
resolver
uniprot
Q3U9D3
resolver
uniprot
Q3UEA5
resolver
uniprot
Q8CIC3
resolver
uniprot_entry
T106A_MOUSE
resolver
uniprot_sec
Q3U4J0
resolver
uniprot_sec
Q3U9D3
resolver
uniprot_sec
Q3UEA5
resolver
uniprot_sec
Q8CIC3
resolver
amino_acid_sequence
MGKAVSQLTSRKDEDKPILPDNPAMASQAANYFSTGSSKPAHSCMPYEKAASSSFVTCPTCQGNGEIPQEQEKQLVALIPYGDQRLKPRRTKLFVFLSVAICLLIFSLTIFFLYPRPIAVRPVGLNSSTVTFEDAHVQLNTTNVLNIFNSNFYPITVTQLTAEVLHQASVVGQVTSSLRLHIGPLASEQMPYEVASRILDENTYKICTWPKIRVHHILLNIQGSLTCSFLSHPQQLPFESFEYVDCRENMSLPHLELPRPA
uniprot
proteins
function
FUNCTION: Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway (PubMed:26215746). Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (PubMed:26215746). May play a role in inhibition of proliferation and migration (By similarity). {ECO:0000250|UniProtKB:Q96A25, ECO:0000269|PubMed:26215746}.
uniprot
proteins
mass_dalton
29109
uniprot
proteins
protein_family
TMEM106 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
26215746
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26215746}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins