PRODH2
entrez
58510
canonical
uniprot
Q9UF12
canonical
ensembl
ENSG00000250799
resolver
ensp
ENSP00000301175
resolver
ensp
ENSP00000499779
resolver
ensp
ENSP00000551844
resolver
ensp
ENSP00000671053
resolver
ensp
ENSP00000671056
resolver
enst
ENST00000301175
resolver
enst
ENST00000653904
resolver
genesymbol
PRODH2
resolver
genesymbol_syn
HSPOX1
resolver
genesymbol_syn
HYPDH
resolver
hgnc
HGNC:17325
resolver
uniprot
A0A590UKC3
resolver
uniprot_entry
HYPDH_HUMAN
resolver
uniprot_sec
A0A590UKC3
resolver
activity_regulation
ACTIVITY REGULATION: Hydroproxyproline dehydrogenase activity is inhibited by THFA,(1R,3R)3-OH-cyclopentane-COOH and 5-OH-1H-pyrazole-3-COOH. {ECO:0000269|PubMed:25697095}.
uniprot
proteins
amino_acid_sequence
MLRTCYVLCSQAGPPSRGWQSLSFDGGAFHLKGTGELTRALLVLRLCAWPPLVTHGLLLQAWSRRLLGSRLSGAFLRASVYGQFVAGETAEEVKGCVQQLRTLSLRPLLAVPTEEEPDSAAKSGEAWYEGNLGAMLRCVDLSRGLLEPPSLAEASLMQLKVTALTSTRLCKELASWVRRPGASLELSPERLAEAMDSGQNLQVSCLNAEQNQHLRASLSRLHRVAQYARAQHVRLLVDAEYTSLNPALSLLVAALAVRWNSPGEGGPWVWNTYQACLKDTFERLGRDAEAAHRAGLAFGVKLVRGAYLDKERAVAQLHGMEDPTQPDYEATSQSYSRCLELMLTHVARHGPMCHLMVASHNEESVRQATKRMWELGIPLDGTVCFGQLLGMCDHVSLALGQAGYVVYKSIPYGSLEEVIPYLIRRAQENRSVLQGARREQELLSQELWRRLLPGCRRIPH
uniprot
proteins
ec_number
1.5.5.2
uniprot
proteins
ec_number
1.5.5.3
uniprot
proteins
function
FUNCTION: Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis. {ECO:0000269|PubMed:25697095}.
uniprot
proteins
mass_dalton
50898
uniprot
proteins
protein_family
Proline oxidase family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
25697095
uniprot
proteins
sequence_length
460
uniprot
proteins