C8G
entrez
733
canonical
uniprot
P07360
canonical
ensembl
ENSG00000176919
resolver
ensp
ENSP00000360697
resolver
ensp
ENSP00000540219
resolver
ensp
ENSP00000648569
resolver
enst
ENST00000371634
resolver
enst
ENST00000870160
resolver
genesymbol
C8G
resolver
hgnc
HGNC:1354
resolver
uniprot
Q14CT8
resolver
uniprot
Q14CU0
resolver
uniprot
Q5SQ07
resolver
uniprot_entry
CO8G_HUMAN
resolver
uniprot_sec
Q14CT8
resolver
uniprot_sec
Q14CU0
resolver
uniprot_sec
Q5SQ07
resolver
activity_regulation
ACTIVITY REGULATION: Membrane attack complex (MAC) assembly is inhibited by CD59, thereby protecting self-cells from damage during complement activation (PubMed:36797260). MAC assembly is also inhibited by clusterin (CLU) chaperones that inhibit polymerization of C9 (PubMed:34667172). {ECO:0000269|PubMed:34667172, ECO:0000269|PubMed:36797260}.
uniprot
proteins
amino_acid_sequence
MLPPGTATLLTLLLAAGSLGQKPQRPRRPASPISTIQPKANFDAQQFAGTWLLVAVGSACRFLQEQGHRAEATTLHVAPQGTAMAVSTFRKLDGICWQVRQLYGDTGVLGRFLLQARDARGAVHVVVAETDYQSFAVLYLERAGQLSVKLYARSLPVSDSVLSGFEQRVQEAHLTEDQIFYFPKYGFCEAADQFHVLDEVRR
uniprot
proteins
function
FUNCTION: Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:26841837, PubMed:27052168, PubMed:30552328). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:30552328, PubMed:39914456, PubMed:39814882). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:30552328). C8G, together with C8A and C8B, inserts into the target membrane, but does not form pores by itself (PubMed:30552328). During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity (PubMed:30552328, PubMed:6833260). {ECO:0000269|PubMed:26841837, ECO:0000269|PubMed:27052168, ECO:0000269|PubMed:30552328, ECO:0000269|PubMed:39814882, ECO:0000269|PubMed:39914456, ECO:0000269|PubMed:6833260}.
uniprot
proteins
mass_dalton
22277
uniprot
proteins
protein_family
Calycin superfamily
uniprot
proteins
protein_family
Lipocalin family
uniprot
proteins
pubmed
11058761
uniprot
proteins
pubmed
12033936
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1707134
uniprot
proteins
pubmed
17452033
uniprot
proteins
pubmed
17692377
uniprot
proteins
pubmed
21454577
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2446620
uniprot
proteins
pubmed
2447883
uniprot
proteins
pubmed
26841837
uniprot
proteins
pubmed
27052168
uniprot
proteins
pubmed
30552328
uniprot
proteins
pubmed
31061395
uniprot
proteins
pubmed
34667172
uniprot
proteins
pubmed
3676249
uniprot
proteins
pubmed
36797260
uniprot
proteins
pubmed
39814882
uniprot
proteins
pubmed
39914456
uniprot
proteins
pubmed
6833260
uniprot
proteins
pubmed
8172891
uniprot
proteins
sequence_length
202
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3676249}. Target cell membrane {ECO:0000269|PubMed:30552328, ECO:0000269|PubMed:31061395}. Note=Secreted as soluble protein (PubMed:30552328). Inserts into the cell membrane of target cells (PubMed:30552328, PubMed:31061395). {ECO:0000269|PubMed:30552328, ECO:0000269|PubMed:31061395}.
uniprot
proteins