Cdk5r1
entrez
116671
canonical
uniprot
P61810
canonical
ensembl
ENSRNOG00000068243
resolver
ensembl
ENSRNOG00055030371
resolver
ensembl
ENSRNOG00060031591
resolver
ensembl
ENSRNOG00065023983
resolver
ensp
ENSRNOP00000079807
resolver
ensp
ENSRNOP00000098931
resolver
ensp
ENSRNOP00000111001
resolver
ensp
ENSRNOP00055043545
resolver
ensp
ENSRNOP00060045276
resolver
ensp
ENSRNOP00065033580
resolver
enst
ENSRNOT00000119428
resolver
enst
ENSRNOT00000147921
resolver
enst
ENSRNOT00000160992
resolver
enst
ENSRNOT00055052675
resolver
enst
ENSRNOT00060054741
resolver
enst
ENSRNOT00065041130
resolver
genesymbol
Cdk5r1
resolver
genesymbol_syn
Cdk5r
resolver
uniprot
Q62938
resolver
uniprot_entry
CD5R1_RAT
resolver
uniprot_sec
Q62938
resolver
amino_acid_sequence
MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKAQPNSSYQSNIAHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGVSSSVKKAPHPAITSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR
uniprot
proteins
function
FUNCTION: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000250|UniProtKB:Q15078}.
uniprot
proteins
mass_dalton
34031
uniprot
proteins
mutagenesis
MUTAGEN 138; /note="T->A: Increased susceptibility to calpain cleavage."; /evidence="ECO:0000269|PubMed:17121855"; MUTAGEN 138; /note="T->E: Decreased susceptibility to calpain cleavage."; /evidence="ECO:0000269|PubMed:17121855
uniprot
proteins
post_translational_modification
PTM: The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10 fold shorter half-life compared to p25. The conversion results in deregulation of the CDK5 kinase: p25/CDK5 kinase displays an increased and altered tau phosphorylation in comparison to the p35/CDK5 kinase in vivo. {ECO:0000269|PubMed:10903889, ECO:0000269|PubMed:17121855}.; PTM: Myristoylated. A proper myristoylation signal is essential for the proper distribution of p35 (By similarity). {ECO:0000250|UniProtKB:Q15078}.; PTM: Phosphorylation at Ser-8 and Thr-138 by CDK5 prevents calpain-mediated proteolysis. {ECO:0000250|UniProtKB:Q15078}.; PTM: Ubiquitinated, leading to its degradation: degradation of p35 by proteasome results in down-regulation of CDK5 activity. During this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation. Ubiquitinated by the CRL2(FEM1B) complex, which recognizes the -Gly-Leu-Asp-Arg C-degron at the C-terminus, leading to its degradation. {ECO:0000250|UniProtKB:Q15078}.
uniprot
proteins
protein_family
Cyclin-dependent kinase 5 activator family
uniprot
proteins
pubmed
10903889
uniprot
proteins
pubmed
15128856
uniprot
proteins
pubmed
17121855
uniprot
proteins
pubmed
17143272
uniprot
proteins
pubmed
8662984
uniprot
proteins
sequence_length
307
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Cyclin-dependent kinase 5 activator 1, p35]: Cell membrane {ECO:0000250|UniProtKB:Q15078}; Lipid-anchor {ECO:0000250|UniProtKB:Q15078}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15078}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q15078}. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals. {ECO:0000250|UniProtKB:Q15078}.; SUBCELLULAR LOCATION: [Cyclin-dependent kinase 5 activator 1, p25]: Nucleus {ECO:0000250|UniProtKB:Q15078}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q15078}. Perikaryon {ECO:0000250|UniProtKB:Q15078}. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites. {ECO:0000250|UniProtKB:Q15078}.
uniprot
proteins