Pdzk1
entrez
65144
canonical
uniprot
Q9JJ40
canonical
ensembl
ENSRNOG00000000096
resolver
ensp
ENSRNOP00000000107
resolver
enst
ENSRNOT00000000107
resolver
genesymbol
Pdzk1
resolver
genesymbol_syn
Clamp
resolver
genesymbol_syn
Diphor1
resolver
genesymbol_syn
Nherf3
resolver
uniprot
O35234
resolver
uniprot
Q6AZ21
resolver
uniprot_entry
NHRF3_RAT
resolver
uniprot_sec
O35234
resolver
uniprot_sec
Q6AZ21
resolver
amino_acid_sequence
MASTFNPRECKLSKKEGQNYGFFLRIEKDTDGHLVRVIEEGSPAEKAGLLDGDRVLRINGVFVDKEEHAQVVDLVRKSGNSVTLLVLDGDSYEKAVKHQVDLKELDQSPREPALNEKKPDLGMNGGVETCAQPRLCYLVKEGNSFGFSLKTIQGKKGVFLTDITPQGVAMKAGVLADDHLIEVNGENVENASHEEVVEKVTKSGSRIMFLLVDKETARCHSEQKTPFKRETASLKLLPHQPRVVVIKKGSNGYGFYLRAGPEQKGQIIKDIEPGSPAEAAGLKNNDLVVAVNGESVEALDHDGVVEMIRNGGDQTTLLVLDKEADRIYSLARFSPLLYCQSQELPNGSVKEAPAPISAPLEAPGSATTEDVGDHKPKLCRLIKEDDSYGFHLNAIRGQPGSFVKEVQQGGPADKAGLENEDIIIEVNGENVQDEPYDRVVERIKSSGEHVTLLVCGKVAYSYFQAKKIPILSSLADPLVAGPDAKGETEHDSAESTKDSSHPARDRTLSAASHSSSNSEDTVM
uniprot
proteins
function
FUNCTION: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity (By similarity). Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity). Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts (via PDZ1 domain) directly with KLHL17; the interaction is important for integrity of actin cytoskeleton structures in neurons. {ECO:0000250, ECO:0000269|PubMed:9374845}.
uniprot
proteins
mass_dalton
56800
uniprot
proteins
protein_family
NHER family
uniprot
proteins
pubmed
10829064
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15994332
uniprot
proteins
pubmed
16054660
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9374845
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10829064}; Peripheral membrane protein {ECO:0000269|PubMed:10829064}. Cell membrane {ECO:0000250|UniProtKB:Q9JIL4}. Note=Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes. {ECO:0000269|PubMed:10829064}.
uniprot
proteins