MAP3K14
entrez
9020
canonical
uniprot
Q99558
canonical
ensembl
ENSG00000006062
resolver
ensp
ENSP00000478552
resolver
ensp
ENSP00000480974
resolver
ensp
ENSP00000482657
resolver
ensp
ENSP00000572511
resolver
ensp
ENSP00000572512
resolver
ensp
ENSP00000640484
resolver
ensp
ENSP00000640485
resolver
enst
ENST00000344686
resolver
enst
ENST00000376926
resolver
enst
ENST00000617331
resolver
enst
ENST00000902452
resolver
enst
ENST00000902453
resolver
enst
ENST00000970425
resolver
enst
ENST00000970426
resolver
genesymbol
MAP3K14
resolver
genesymbol_syn
NIK
resolver
hgnc
HGNC:6853
resolver
uniprot
A8K2D8
resolver
uniprot
D3DX67
resolver
uniprot
Q8IYN1
resolver
uniprot_entry
M3K14_HUMAN
resolver
uniprot_sec
A8K2D8
resolver
uniprot_sec
D3DX67
resolver
uniprot_sec
Q8IYN1
resolver
amino_acid_sequence
MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILNDVITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNNVAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQEDESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVWKLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPHLSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPEPPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLNSLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSSSWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFSLVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 112 (IMD112) [MIM:620449]: An autosomal recessive, primary immunologic disorder characterized by variable abnormalities affecting lymphoid immunity, including hypogammaglobulinemia, lymphopenia or paradoxical lymphocytosis, and recurrent bacterial, viral, and fungal infections. {ECO:0000269|PubMed:25406581, ECO:0000269|PubMed:29230214}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway (PubMed:25406581, PubMed:29230214). Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response (PubMed:25406581). Could act in a receptor-selective manner. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:25406581}.
uniprot
proteins
mass_dalton
104042
uniprot
proteins
mutagenesis
MUTAGEN 429..430; /note="KK->AA: Loss of autophosphorylation and 'Lys-63'-linked ubiquitination. Unable to phosphorylate CHUK/IKKA."; /evidence="ECO:0000269|PubMed:20682767, ECO:0000269|PubMed:25406581, ECO:0000269|PubMed:9020361"; MUTAGEN 559; /note="T->A: Abolishes 'Lys-63'-linked ubiquitination."; /evidence="ECO:0000269|PubMed:20682767
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Phosphorylation at Thr-559 is required to activate its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization. {ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:20682767}.; PTM: Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it.
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
12853971
uniprot
proteins
pubmed
12874243
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15084608
uniprot
proteins
pubmed
15173580
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15951441
uniprot
proteins
pubmed
17237370
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
20501937
uniprot
proteins
pubmed
20682767
uniprot
proteins
pubmed
22718757
uniprot
proteins
pubmed
22921830
uniprot
proteins
pubmed
25406581
uniprot
proteins
pubmed
29230214
uniprot
proteins
pubmed
30341167
uniprot
proteins
pubmed
9020361
uniprot
proteins
sequence_length
947
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins