A1A5P5
uniprot
A1A5P5
canonical
amino_acid_sequence
MGDVLAHESELLGLVKEYLDFAEFEDTLKTFSKECKVKGKPLCKTVGGSLKKDSNSLMIQKDLVAAFDSGDQKLFFDLWEGHIPSSIRDTDSLAQKLEFYLHIHFAIYLLKYSGGRPDRQELDERISYFKTYLETKGASLSQTTEFLPFYALPFVPNPMVHPSFKELFQDSWTPELKLKLEKFLALIFKASNTPKLLTIYKENGSNNKEMLQQLHQQLLEAERRAMAYLKRYNKMQADYHSLIGVTAELVDSLEATVSGKMITPEYLQSVCVRLFSNQMRQSLAHSVDFTRPGTASTMLRASLAPEKLKDVPLLPSLDYEKLKKDLIWGSDRLKAFLLQALRWRLTTSHPGEQRETVLQAYISNDLLDCHSHNQRSVLQLLHSKSEAVRQYMARLVNALASLAEGRLYLAQNTKVLRMLEGRLKEEDKDVITRENVLGALQKFSLRRPLQTAMIRDGLIFWLIDLLKEPDCLSDYTLEYSVALLMNLCLRSAGKNMCAKVAGLMLKVLSDLLGHENHEIQPYVNGALYSILSIPSIREEARAMGMEDILRCFIKEGNAEMIRQIEFIIKQLNSEDLLDGVLESDDDEDEDDEEDHDIMEADLDKDELIQPQLGELSGEKLLTTEYLGIMTNTGKARRKGLASVQWSGDEPLRRPVTPGGHRTGCPVVGDHLISSQNAQQARNGCPRPIPVAQPDDYKEGKRGVAGRATPSSCKSAECAEPVLSSGAQKPK
uniprot
proteins
function
FUNCTION: Involved in ciliogenesis. It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length (By similarity). Acts as a positive regulator of hedgehog (Hh)signaling (By similarity). May participate in the trafficking and/or retention of GLI2 and GLI3 proteins at the ciliary tip (By similarity). {ECO:0000250|UniProtKB:E7F187, ECO:0000250|UniProtKB:Q7Z3E5, ECO:0000250|UniProtKB:Q9D2I5}.
uniprot
proteins
mass_dalton
82337
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
730
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q7Z3E5}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9D2I5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q7Z3E5}. Note=Localized to the proximal region in cilia. Stimulation of Hh signaling leads to redistribution of ARMC9 toward the ciliary tip within 6 hours, follow by a gradual return to its original proximal location (By similarity). Localizes to the daughter centriole of the primary cilium in RPE1 cells (By similarity). {ECO:0000250|UniProtKB:Q7Z3E5, ECO:0000250|UniProtKB:Q9D2I5}.
uniprot
proteins