SPARC
entrez
6678
canonical
uniprot
P09486
canonical
ensembl
ENSG00000113140
resolver
ensp
ENSP00000231061
resolver
ensp
ENSP00000566486
resolver
ensp
ENSP00000566487
resolver
ensp
ENSP00000566488
resolver
ensp
ENSP00000566489
resolver
ensp
ENSP00000566494
resolver
ensp
ENSP00000566495
resolver
ensp
ENSP00000566496
resolver
ensp
ENSP00000566501
resolver
ensp
ENSP00000566502
resolver
ensp
ENSP00000566503
resolver
ensp
ENSP00000566504
resolver
ensp
ENSP00000621439
resolver
ensp
ENSP00000621442
resolver
ensp
ENSP00000621443
resolver
ensp
ENSP00000644977
resolver
enst
ENST00000231061
resolver
enst
ENST00000896427
resolver
enst
ENST00000896428
resolver
enst
ENST00000896430
resolver
enst
ENST00000896435
resolver
enst
ENST00000896436
resolver
enst
ENST00000896437
resolver
enst
ENST00000896442
resolver
enst
ENST00000896443
resolver
enst
ENST00000896444
resolver
enst
ENST00000896445
resolver
enst
ENST00000951380
resolver
enst
ENST00000951383
resolver
enst
ENST00000951384
resolver
genesymbol
SPARC
resolver
genesymbol_syn
ON
resolver
hgnc
HGNC:11219
resolver
uniprot
D3DQH9
resolver
uniprot
Q6IBK4
resolver
uniprot_entry
SPRC_HUMAN
resolver
uniprot_sec
D3DQH9
resolver
uniprot_sec
Q6IBK4
resolver
amino_acid_sequence
MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAEETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQKDIDKDLVI
uniprot
proteins
disease_involvement
DISEASE: Osteogenesis imperfecta 17 (OI17) [MIM:616507]: An autosomal recessive form of osteogenesis imperfecta, a disorder of bone formation characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. {ECO:0000269|PubMed:26027498}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
uniprot
proteins
mass_dalton
34632
uniprot
proteins
mutagenesis
MUTAGEN 166; /note="R->A,L,K: Strongly reduced collagen binding."; /evidence="ECO:0000269|PubMed:9501084"; MUTAGEN 173; /note="N->A,Q: Strongly reduced collagen binding."; /evidence="ECO:0000269|PubMed:9501084"; MUTAGEN 259; /note="L->A: Loss of collagen binding."; /evidence="ECO:0000269|PubMed:9501084"; MUTAGEN 262; /note="M->A: Strongly reduced collagen binding."; /evidence="ECO:0000269|PubMed:9501084"; MUTAGEN 263; /note="E->A: Loss of collagen binding."; /evidence="ECO:0000269|PubMed:9501084
uniprot
proteins
protein_family
SPARC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
2306517
uniprot
proteins
pubmed
2338025
uniprot
proteins
pubmed
26027498
uniprot
proteins
pubmed
2790009
uniprot
proteins
pubmed
2838412
uniprot
proteins
pubmed
3400777
uniprot
proteins
pubmed
3410046
uniprot
proteins
pubmed
3597437
uniprot
proteins
pubmed
7495300
uniprot
proteins
pubmed
8548457
uniprot
proteins
pubmed
9233787
uniprot
proteins
pubmed
9457905
uniprot
proteins
pubmed
9501084
uniprot
proteins
sequence_length
303
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:2306517, ECO:0000269|PubMed:3400777, ECO:0000269|PubMed:7495300, ECO:0000269|PubMed:9457905}. Note=In or around the basement membrane.
uniprot
proteins