KLK7
entrez
5650
canonical
uniprot
P49862
canonical
ensembl
ENSG00000169035
resolver
ensp
ENSP00000375683
resolver
ensp
ENSP00000469950
resolver
ensp
ENSP00000470538
resolver
genesymbol
KLK7
resolver
genesymbol_syn
PRSS6
resolver
genesymbol_syn
SCCE
resolver
hgnc
HGNC:6368
resolver
uniprot
A8K0U5
resolver
uniprot
B4DHX9
resolver
uniprot
Q8N5N9
resolver
uniprot
Q8NFV7
resolver
uniprot_entry
B4DHX9_HUMAN
resolver
uniprot_entry
KLK7_HUMAN
resolver
uniprot_sec
A8K0U5
resolver
uniprot_sec
Q8N5N9
resolver
uniprot_sec
Q8NFV7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Zn2+ and Cu2+ at low micromolar concentrations. Inhibited by SERPINA12. {ECO:0000269|PubMed:23370777}.
uniprot
proteins
amino_acid_sequence
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
uniprot
proteins
ec_number
3.4.21.117
uniprot
proteins
function
FUNCTION: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. {ECO:0000269|PubMed:23370777}.
uniprot
proteins
mass_dalton
27525
uniprot
proteins
mutagenesis
MUTAGEN 54; /note="H->F: No effect on zinc inhibition."; /evidence="ECO:0000269|PubMed:17909180"; MUTAGEN 109; /note="H->A: No zinc inhibition."; /evidence="ECO:0000269|PubMed:17909180
uniprot
proteins
protein_family
Kallikrein subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10974542
uniprot
proteins
pubmed
11054574
uniprot
proteins
pubmed
11874483
uniprot
proteins
pubmed
12738725
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17909180
uniprot
proteins
pubmed
18329042
uniprot
proteins
pubmed
23370777
uniprot
proteins
pubmed
7794273
uniprot
proteins
pubmed
8034709
uniprot
proteins
sequence_length
253
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12738725}. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.
uniprot
proteins