Soat2
entrez
266770
canonical
uniprot
Q7TQM4
canonical
ensembl
ENSRNOG00000053769
resolver
ensp
ENSRNOP00000071253
resolver
genesymbol
Soat2
resolver
genesymbol_syn
Acat2
resolver
uniprot_entry
SOAT2_RAT
resolver
amino_acid_sequence
MEPKAPQLRRRERQGEEQENGACGEGNTRTHRAPDLVQWTRHMEAVKTQCLEQAQRELAELMDRAIWEAVQAYPKQDRPLPSTASDSTRKTQELHPGKRKVFITRKSLLDELMGVQHFRTIYHMFIAGLCVLIISTLAIDFIDEGRLMLEFDLLLFSFGQLPLALMMWVPMFLSTLLLPYQTLRLWARPRSGGAWTLGASLGCVLLAAHAAVLCVLPVHVSVKHELPPASRCVLVFEQVRFLMKSYSFLRETVPGIFCVRGGKGICTPSFSSYLYFLFCPTLIYRETYPRTPSIRWNYVAKNFAQALGCLLYACFILGRLCVPVFANMSREPFSTRALLLSILHATGPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLWLLGRQGRGAAMLGVFLVSALVHEYIFCFVLGFFYPVMLILFLVVGGLLNFTMNDRHTGPAWNILMWTFLFLGQGIQVSLYCQEWYARRHCPLPQPTFWELVTPRSWSCHP
uniprot
proteins
ec_number
2.3.1.26
uniprot
proteins
function
FUNCTION: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa. {ECO:0000250|UniProtKB:O75908}.
uniprot
proteins
mass_dalton
60498
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated by AMFR/gp78 at Cys-279, leading to its degradation when the lipid levels are low. Association with AMFR/gp78 is mediated via interaction with INSIG1. High concentration of cholesterol and fatty acid results in Cys-279 oxidation, preventing ubiquitination at the same site, resulting in protein stabilization. {ECO:0000250|UniProtKB:O75908}.; PTM: Oxidized at Cys-279: high concentration of cholesterol and fatty acid induce reactive oxygen species, which oxidizes Cys-279, preventing ubiquitination at the same site, and resulting in protein stabilization. {ECO:0000250|UniProtKB:O75908}.
uniprot
proteins
protein_family
Membrane-bound acyltransferase family
uniprot
proteins
protein_family
Sterol o-acyltransferase subfamily
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O88908}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 119..140; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 161..186; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 199..222; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 231..254; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 296..328; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 346..371; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 420..444; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 451..466; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 473..504; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P35610
uniprot
proteins