ID2
entrez
3398
canonical
uniprot
Q02363
canonical
ensembl
ENSG00000115738
resolver
ensp
ENSP00000234091
resolver
ensp
ENSP00000379585
resolver
ensp
ENSP00000385465
resolver
ensp
ENSP00000525919
resolver
ensp
ENSP00000599769
resolver
enst
ENST00000234091
resolver
enst
ENST00000331129
resolver
enst
ENST00000396290
resolver
enst
ENST00000855860
resolver
enst
ENST00000929710
resolver
genesymbol
GIG8
resolver
genesymbol
ID2
resolver
genesymbol_syn
BHLHB26
resolver
genesymbol_syn
ID2
resolver
hgnc
HGNC:5361
resolver
uniprot
D6W4Y7
resolver
uniprot
Q53T66
resolver
uniprot_entry
ID2_HUMAN
resolver
uniprot_entry
Q53T66_HUMAN
resolver
uniprot_sec
D6W4Y7
resolver
amino_acid_sequence
MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQASRTPLTTLNTDISILSLQASEFPSELMSNDSKALCG
uniprot
proteins
function
FUNCTION: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. {ECO:0000269|PubMed:20861012}.
uniprot
proteins
mass_dalton
14917
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated in a ASB4-dependent manner, leading to proteasomal degradation. {ECO:0000269|PubMed:24586788}.; PTM: Phosphorylated in vitro by CDK1, PKA and PKC. {ECO:0000250|UniProtKB:P41137}.
uniprot
proteins
pubmed
10502414
uniprot
proteins
pubmed
14752053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1741406
uniprot
proteins
pubmed
20861012
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24586788
uniprot
proteins
pubmed
8294468
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P41136}. Nucleus {ECO:0000250|UniProtKB:P41136}.
uniprot
proteins