Tle1
entrez
21885
canonical
uniprot
Q62440
canonical
ensembl
ENSMUSG00000008305
resolver
ensp
ENSMUSP00000030095
resolver
ensp
ENSMUSP00000072481
resolver
ensp
ENSMUSP00000099912
resolver
ensp
ENSMUSP00000102960
resolver
ensp
ENSMUSP00000254827
resolver
ensp
ENSMUSP00000254828
resolver
ensp
ENSMUSP00000254829
resolver
ensp
ENSMUSP00000254830
resolver
ensp
ENSMUSP00000254831
resolver
ensp
ENSMUSP00000254833
resolver
ensp
ENSMUSP00000254836
resolver
ensp
ENSMUSP00000254837
resolver
ensp
ENSMUSP00000254838
resolver
ensp
ENSMUSP00000254849
resolver
ensp
ENSMUSP00000254853
resolver
ensp
ENSMUSP00000254867
resolver
ensp
ENSMUSP00000254881
resolver
ensp
ENSMUSP00000254885
resolver
ensp
ENSMUSP00000343200
resolver
enst
ENSMUST00000030095
resolver
enst
ENSMUST00000072695
resolver
enst
ENSMUST00000102848
resolver
genesymbol
Tle1
resolver
genesymbol_syn
Grg1
resolver
uniprot
Q5SQA2
resolver
uniprot
Q5SQA3
resolver
uniprot
Q5SQA4
resolver
uniprot
Q5SQA8
resolver
uniprot
Q6PFG2
resolver
uniprot_entry
Q5SQA2_MOUSE
resolver
uniprot_entry
Q5SQA3_MOUSE
resolver
uniprot_entry
Q5SQA4_MOUSE
resolver
uniprot_entry
Q6PFG2_MOUSE
resolver
uniprot_entry
TLE1_MOUSE
resolver
uniprot_sec
Q5SQA8
resolver
amino_acid_sequence
MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSASLLALSSALSGQSHLAIKDDKKHHDAERHRDRESGTSNSLLVPDSLRSTDKRRNGPEFSSDIKKRKVDDKDNYDSDGDKSDDNLVVDVSNEDPSSPHASPTHSPRENGIDKNRLLKKDASGSPASTASSGSSSSLKSKEVSLHEKANTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAMEPLVNQAAAGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYAGLHSMSPQMSAAAAAAAAAVVAYGRSPMVGFDPPPHMRVPSIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY
uniprot
proteins
function
FUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (PubMed:16314515). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG (By similarity). {ECO:0000250, ECO:0000269|PubMed:16314515}.
uniprot
proteins
mass_dalton
83097
uniprot
proteins
post_translational_modification
PTM: Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1. {ECO:0000269|PubMed:11756536, ECO:0000269|PubMed:8713081}.; PTM: Ubiquitinated by XIAP/BIRC4. {ECO:0000250}.
uniprot
proteins
protein_family
WD repeat Groucho/TLE family
uniprot
proteins
pubmed
11266540
uniprot
proteins
pubmed
11756536
uniprot
proteins
pubmed
12359720
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16314515
uniprot
proteins
pubmed
18254933
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21429299
uniprot
proteins
pubmed
23990468
uniprot
proteins
pubmed
8713081
uniprot
proteins
pubmed
8892234
uniprot
proteins
sequence_length
770
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8713081}. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.; SUBCELLULAR LOCATION: [Isoform 7]: Nucleus {ECO:0000269|PubMed:12359720}. Cytoplasm {ECO:0000269|PubMed:12359720}.; SUBCELLULAR LOCATION: [Isoform 8]: Nucleus {ECO:0000269|PubMed:12359720}. Cytoplasm {ECO:0000269|PubMed:12359720}.
uniprot
proteins