Klhdc3
entrez
71765
canonical
uniprot
Q8VEM9
canonical
ensembl
ENSMUSG00000063576
resolver
ensp
ENSMUSP00000071743
resolver
ensp
ENSMUSP00000128271
resolver
ensp
ENSMUSP00000189568
resolver
enst
ENSMUST00000071841
resolver
enst
ENSMUST00000165007
resolver
genesymbol
Klhdc3
resolver
genesymbol_syn
Peas
resolver
uniprot
A0A0R4J0W0
resolver
uniprot
Q3TCN9
resolver
uniprot
Q3UR95
resolver
uniprot
Q91XU6
resolver
uniprot
Q99JH9
resolver
uniprot
Q9DBG8
resolver
uniprot_entry
A0A0R4J0W0_MOUSE
resolver
uniprot_entry
KLDC3_MOUSE
resolver
uniprot_sec
Q3TCN9
resolver
uniprot_sec
Q3UR95
resolver
uniprot_sec
Q91XU6
resolver
uniprot_sec
Q99JH9
resolver
uniprot_sec
Q9DBG8
resolver
amino_acid_sequence
MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVRPAVRGQAPVVPYMRYGHSTVLIDDTVFLWGGRNDTEGACNVLYAFDVNTHKWSTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQLADCFSNDIHKLDTSTMTWTLVCTKGNPARWRDFHSATMLGNHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPHTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPGSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYSLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons. The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine (By similarity). May be involved in meiotic recombination process (PubMed:12606021). {ECO:0000250|UniProtKB:Q9BQ90, ECO:0000269|PubMed:12606021}.
uniprot
proteins
mass_dalton
43082
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9BQ90}.
uniprot
proteins
pubmed
12444059
uniprot
proteins
pubmed
12606021
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12606021}. Note=Also found in meiotic chromatin. {ECO:0000269|PubMed:12606021}.
uniprot
proteins