Cox6a1
entrez
12861
canonical
uniprot
P43024
canonical
ensembl
ENSMUSG00000041697
resolver
ensp
ENSMUSP00000047661
resolver
enst
ENSMUST00000040154
resolver
genesymbol
Cox6a1
resolver
genesymbol_syn
Cox6al
resolver
uniprot
F6YXD0
resolver
uniprot
Q9DCW5
resolver
uniprot_entry
CX6A1_MOUSE
resolver
uniprot_entry
F6YXD0_MOUSE
resolver
uniprot_entry
Q9DCW5_MOUSE
resolver
amino_acid_sequence
MASAVLSASRVSRPLGRALPGLRRPMSSGAHGEEGSARMWKALTYFVALPGVGVSMLNVFLKSRHEEHERPPFVAYPHLRIRTKPFPWGDGNHTLFHNPHVNPLPTGYEDE
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P32799}.
uniprot
proteins
mass_dalton
12352
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P32799}.
uniprot
proteins
protein_family
Cytochrome c oxidase subunit 6A family
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25152455
uniprot
proteins
pubmed
7873616
uniprot
proteins
sequence_length
111
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P12074}; Single-pass membrane protein {ECO:0000250|UniProtKB:P12074}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..61; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P07471
uniprot
proteins