SMYD5
entrez
10322
canonical
uniprot
Q6GMV2
canonical
ensembl
ENSG00000135632
resolver
ensp
ENSP00000374152
resolver
enst
ENST00000389501
resolver
genesymbol
SMYD5
resolver
genesymbol_syn
RAI15
resolver
hgnc
HGNC:16258
resolver
uniprot
D6W5H3
resolver
uniprot
Q13558
resolver
uniprot_entry
SMYD5_HUMAN
resolver
uniprot_sec
D6W5H3
resolver
uniprot_sec
Q13558
resolver
amino_acid_sequence
MAASMCDVFSFCVGVAGRARVSVEVRFVSSAKGKGLFATQLIRKGETIFVERPLVAAQFLWNALYRYRACDHCLRALEKAEENAQRLTGKPGQVLPHPELCTVRKDLHQNCPHCQVMYCSAECRLAATEQYHQVLCPGPSQDDPLHPLNKLQEAWRSIHYPPETASIMLMARMVATVKQAKDKDRWIRLFSQFCNKTANEEEEIVHKLLGDKFKGQLELLRRLFTEALYEEAVSQWFTPDGFRSLFALVGTNGQGIGTSSLSQWVHACDTLELKPQDREQLDAFIDQLYKDIEAATGEFLNCEGSGLFVLQSCCNHSCVPNAETSFPENNFLLHVTALEDIKPGEEICISYLDCCQRERSRHSRHKILRENYLFVCSCPKCLAEADEPNVTSEEEEEEEEEEEGEPEDAELGDEMTDV
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.359
uniprot
proteins
ec_number
2.1.1.372
uniprot
proteins
function
FUNCTION: Protein-lysine N-trimethyltransferase that specifically catalyzes trimethylation of 'Lys-22' of the RPL40/eL40 subunit of the 60S ribosome, thereby promoting translation elongation and protein synthesis (PubMed:39048817, PubMed:39103523). May also act as a histone methyltransferase in the context of histone octamers, but not on nucleosome substrates: trimethylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 to form H3K36me3 and H4K20me3, respectively (By similarity). The histone methyltransferase activity, which is independent of its SET domain, is however unsure in vivo (PubMed:39048817, PubMed:39103523). In association with the NCoR corepressor complex, involved in the repression of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages, possibly by catalyzing the formation of H4K20me3 at the gene promoters (By similarity). Plays an important role in embryonic stem (ES) cell self-renewal and differentiation (By similarity). Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by promoting H4K20me3 marks (PubMed:28951459). Acts as a regulator of the hypothermia response: its degradation in response to mild hypothermia relieves the formation of H3K36me3 at gene promoters, allowing expression of the neuroprotective gene SP1 (By similarity). {ECO:0000250|UniProtKB:Q3TYX3, ECO:0000269|PubMed:28951459, ECO:0000269|PubMed:39048817, ECO:0000269|PubMed:39103523}.
uniprot
proteins
mass_dalton
47341
uniprot
proteins
mutagenesis
MUTAGEN 351; /note="Y->A: Abolished trimethylation of 'Lys-22' of the RPL40/eL40 subunit of the 60S ribosome."; /evidence="ECO:0000269|PubMed:39048817
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated and degradaed by the proteasome in response to mild hypothermia (32 degrees Celsius), relieving repression of the SP1 gene. {ECO:0000250|UniProtKB:Q3TYX3}.
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
28951459
uniprot
proteins
pubmed
39048817
uniprot
proteins
pubmed
39103523
uniprot
proteins
pubmed
8754834
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:39048817, ECO:0000269|PubMed:39103523}.
uniprot
proteins