Q00910
uniprot
Q00910
canonical
amino_acid_sequence
MGLLLKPGARQGSGTSSVPDRRCPRSVFSNIKVFVLCHGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNATLIIFISYFGSRVNRPRMIGIGGLLLAAGAFVLTLPHFLSEPYQYTSTTDGNRSSFQTDLCQKHFGALPPSKCHSTVPDTHKETSSLWGLMVVAQLLAGIGTVPIQPFGISYVDDFAEPTNSPLYISILFAIAVFGPAFGYLLGSVMLRIFVDYGRVDTATVNLSPGDPRWIGAWWLGLLISSGFLIVTSLPFFFFPRAMSRGAERSVTAEETMQTEEDKSRGSLMDFIKRFPRIFLRLLMNPLFMLVVLSQCTFSSVIAGLSTFLNKFLEKQYGATAAYANFLIGAVNLPAAALGMLFGGILMKRFVFPLQTIPRVAATIITISMILCVPLFFMGCSTSAVAEVYPPSTSSSIHPQQPPACRRDCSCPDSFFHPVCGDNGVEYVSPCHAGCSSTNTSSEASKEPIYLNCSCVSGGSASAKTGSCPTSCAQLLLPSIFLISFAALIACISHNPLYMMVLRVVNQDEKSFAIGVQFLLMRLLAWLPAPSLYGLLIDSSCVRWNYLCSGRRGACAYYDNDALRNRYLGLQMVYKALGTLLLFFISWRMKKNREYSLQENTSGLI
uniprot
proteins
function
FUNCTION: Mediates the transport of prostaglandins (PGs, mainly PGE2, PGE1, PGE3, PGF2alpha, PGD2, PGH2) and thromboxanes (thromboxane B2) across the cell membrane (PubMed:10484490, PubMed:11880322, PubMed:11997327, PubMed:15044627, PubMed:15855165, PubMed:20346915, PubMed:7754369). PGs and thromboxanes play fundamental roles in diverse functions such as intraocular pressure, gastric acid secretion, renal salt and water transport, vascular tone, and fever (PubMed:15044627). Plays a role in the clearance of PGs from the circulation through cellular uptake, which allows cytoplasmic oxidation and PG signal termination (PubMed:11997327, PubMed:15044627, PubMed:7754369). PG uptake is dependent upon membrane potential and involves exchange of a monovalent anionic substrate (PGs exist physiologically as an anionic monovalent form) with a stoichiometry of 1:1 for divalent anions or of 1:2 for monovalent anions (By similarity). Uses lactate, generated by glycolysis, as a counter-substrate to mediate PG influx and efflux (PubMed:11997327). Under nonglycolytic conditions, metabolites other than lactate might serve as counter-substrates (PubMed:11997327). Although the mechanism is not clear, this transporter can function in bidirectional mode (By similarity). When apically expressed in epithelial cells, it facilitates transcellular transport (also called vectorial release), extracting PG from the apical medium and facilitating transport across the cell toward the basolateral side, whereupon the PG exits the cell by simple diffusion (PubMed:11880322, PubMed:15044627, PubMed:15855165). In the renal collecting duct, regulates renal Na+ balance by removing PGE2 from apical medium (PGE2 EP4 receptor is likely localized to the luminal/apical membrane and stimulates Na+ resorption) and transporting it toward the basolateral membrane (where PGE2 EP1 and EP3 receptors inhibit Na+ resorption) (PubMed:15855165). Plays a role in endometrium during decidualization, increasing uptake of PGs by decidual cells (By similarity). Involved in critical events for ovulation (By similarity). Regulates extracellular PGE2 concentration for follicular development in the ovaries (By similarity). Expressed intracellularly, may contribute to vesicular uptake of newly synthesized intracellular PGs, thereby facilitating exocytotic secretion of PGs without being metabolized (By similarity). Essential core component of the major type of large-conductance anion channel, Maxi-Cl, which plays essential roles in inorganic anion transport, cell volume regulation and release of ATP and glutamate not only in physiological processes but also in pathological processes (By similarity). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity). {ECO:0000250|UniProtKB:Q92959, ECO:0000250|UniProtKB:Q9EPT5, ECO:0000269|PubMed:10484490, ECO:0000269|PubMed:11880322, ECO:0000269|PubMed:11997327, ECO:0000269|PubMed:15044627, ECO:0000269|PubMed:15855165, ECO:0000269|PubMed:20346915, ECO:0000269|PubMed:7754369, ECO:0000303|PubMed:11997327, ECO:0000303|PubMed:15044627}.
uniprot
proteins
mass_dalton
70387
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
10484490
uniprot
proteins
pubmed
11880322
uniprot
proteins
pubmed
11997327
uniprot
proteins
pubmed
15044627
uniprot
proteins
pubmed
15855165
uniprot
proteins
pubmed
20346915
uniprot
proteins
pubmed
2068100
uniprot
proteins
pubmed
7754369
uniprot
proteins
sequence_length
644
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11997327, ECO:0000269|PubMed:15855165, ECO:0000305|PubMed:7754369}; Multi-pass membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000250|UniProtKB:Q92959}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:11997327}. Lysosome {ECO:0000250|UniProtKB:Q9EPT5}. Note=In kidney cells, it localizes in cytoplasmic domains. {ECO:0000269|PubMed:11997327}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 101..121; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 210..230; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 321..341; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 365..385; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 399..419; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 511..531; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 551..571; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 606..626; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins