Fbxo45
entrez
268882
canonical
uniprot
Q8K3B1
canonical
ensembl
ENSMUSG00000035764
resolver
ensp
ENSMUSP00000040168
resolver
enst
ENSMUST00000042732
resolver
genesymbol
Fbxo45
resolver
uniprot
Q5M7B1
resolver
uniprot_entry
FBSP1_MOUSE
resolver
uniprot_sec
Q5M7B1
resolver
amino_acid_sequence
MAAPGPGAGAASGGASGGGAGAGGGASAGSGSSGVGGRLPSRVLELVFSYLELSELRSCALVCKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKVRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEGPLGTVAVIGIATKRAPMQCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGSFPQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFRGLPKACLYPAVSAVYGNTEVTLVYLGKPLDG
uniprot
proteins
function
FUNCTION: Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1. Functions in substrate recognition but plays also an important role in assembly of the complex (By similarity). Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (PubMed:32341084). Regulates neuron migration during brain development through interaction with N-cadherin/CDH2 after secretion via a non-classical mechanism (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. Polyubiquitinates NMNAT2, an adenylyltransferase that acts as an axon maintenance factor, and regulates its stability and degradation by the proteasome. Acts also by ubiquitinating FBXW7 during prolonged mitotic arrest and promotes FBXW7 proteasomal degradation. Induces subsequently an increase in mitotic slippage and prevents mitotic cell death. In response to influenza infection, mediates interferon-lambda receptor IFNLR1 polyubiquitination and degradation through the ubiquitin-proteasome system by docking with its intracellular receptor domain (By similarity). {ECO:0000250|UniProtKB:P0C2W1, ECO:0000269|PubMed:19398581, ECO:0000269|PubMed:32341084}.
uniprot
proteins
mass_dalton
30605
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="R->E: Allows binding to CUL1 and RBX1 and formation of an authentic SCF (SKP1-CUL1-F-box protein) complex."; /evidence="ECO:0000269|PubMed:19398581
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
FBXO45/Fsn family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19398581
uniprot
proteins
pubmed
19996097
uniprot
proteins
pubmed
32341084
uniprot
proteins
sequence_length
286
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C2W1}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P0CH38}. Presynaptic cell membrane {ECO:0000250|UniProtKB:P0CH38}. Nucleus {ECO:0000250|UniProtKB:P0C2W1}. Note=Secreted by a non-classical mechanism. {ECO:0000250|UniProtKB:P0C2W1}.
uniprot
proteins