Slc5a7
entrez
63993
canonical
uniprot
Q8BGY9
canonical
ensembl
ENSMUSG00000023945
resolver
ensp
ENSMUSP00000093379
resolver
ensp
ENSMUSP00000242995
resolver
ensp
ENSMUSP00000242997
resolver
enst
ENSMUST00000095712
resolver
genesymbol
Slc5a7
resolver
genesymbol_syn
Cht1
resolver
uniprot
Q99PK3
resolver
uniprot
Q9ESW5
resolver
uniprot_entry
SC5A7_MOUSE
resolver
uniprot_sec
Q99PK3
resolver
uniprot_sec
Q9ESW5
resolver
activity_regulation
ACTIVITY REGULATION: Choline uptake activity is regulated by SLC5A7/CHT1 internalization (inactive form) from the cell surface and recycling of internalized SLC5A7/CHT1 into the cell surface (active form) (By similarity). Activated by extracellular chloride ion (By similarity). Specifically inhibited by nanomolar concentrations of hemicholinium 3 (PubMed:11709061, PubMed:15173594). {ECO:0000250|UniProtKB:Q9GZV3, ECO:0000269|PubMed:11709061, ECO:0000269|PubMed:15173594}.
uniprot
proteins
amino_acid_sequence
MSFHVEGLVAIILFYLLIFLVGIWAAWKTKNSGNPEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIGFTAVHAKYQSPWLGTIESVEVYTWLDNFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTDWNQTAYGYPDPKTKEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVLVFGASATAMALLTKTVYGLWYLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRITGGEPYLYLQPLIFYPGYYSDKNGIYNQRFPFKTLSMVTSFFTNICVSYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVRNENIKLNELAPVKPRQSLTLSSTFTNKEALLDVDSSPEGSGTEDNLQ
uniprot
proteins
function
FUNCTION: High-affinity Na(+)-coupled choline transmembrane symporter (PubMed:11709061, PubMed:15173594). Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry (By similarity). Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion (By similarity). Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release (By similarity). SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials (PubMed:11709061, PubMed:15173594). Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity (By similarity). {ECO:0000250|UniProtKB:Q9GZV3, ECO:0000269|PubMed:11709061, ECO:0000269|PubMed:15173594}.
uniprot
proteins
mass_dalton
63365
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKC and dephosphorylated by PP1/PP2A. {ECO:0000269|PubMed:15064333}.
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
11709061
uniprot
proteins
pubmed
15064333
uniprot
proteins
pubmed
15173594
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
580
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000269|PubMed:15173594}; Multi-pass membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:15173594}. Early endosome membrane {ECO:0000250|UniProtKB:Q9GZV3}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9GZV3}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to motor neuron axons. {ECO:0000269|PubMed:15173594}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 126..146; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 275..295; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 318..338; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 436..456; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 482..502; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins