Alas2
entrez
25748
canonical
uniprot
Q63147
canonical
ensembl
ENSRNOG00000000167
resolver
ensp
ENSRNOP00000000180
resolver
ensp
ENSRNOP00000107075
resolver
enst
ENSRNOT00000132434
resolver
genesymbol
Alas2
resolver
genesymbol_syn
Alase
resolver
uniprot
A0ABK0LXT7
resolver
uniprot
Q63895
resolver
uniprot
Q642C1
resolver
uniprot_entry
A0ABK0LXT7_RAT
resolver
uniprot_entry
HEM0_RAT
resolver
uniprot_entry
Q642C1_RAT
resolver
uniprot_sec
Q63895
resolver
amino_acid_sequence
MVAAAMLLRSCPVLSKGPTGLLGKVAKTYQFLFGIGRCPILATQGPTCSQIHLKATKAGADSPSWTKSHCPFMLSELQDRKSKIVQRAAPEVQEDVKTFKTDLLSFMESTTRSQSVPRFQDPEQTGGAPPLLIQNNMTGSQAFGYDQFFRDKIMEKKQDHTYRVFKTVNRWANAYPFAQHFSEASMDSKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSKFHVELEQELAELHHKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRNSGAVKFVFRHNDPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALTFVDEVHAVGLYGTRGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGFPVIPCPSHIIPIRVGNAALNSKICDLLLAKHSIYVQAINYPTVPRGEELLRLAPSPHHSPQMMENFVEKLLLAWTEVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA
uniprot
proteins
ec_number
2.3.1.37
uniprot
proteins
function
FUNCTION: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (PubMed:8407861). Contributes significantly to heme formation during erythropoiesis (By similarity). {ECO:0000250|UniProtKB:P22557, ECO:0000269|PubMed:8407861}.
uniprot
proteins
mass_dalton
64842
uniprot
proteins
pathway_participation
PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1. {ECO:0000305|PubMed:8407861}.
uniprot
proteins
protein_family
Class-II pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
2369125
uniprot
proteins
pubmed
8407861
uniprot
proteins
sequence_length
587
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:2369125}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to the matrix side of the mitochondrion inner membrane. {ECO:0000269|PubMed:2369125}.
uniprot
proteins