Chrna7
entrez
25302
canonical
uniprot
Q05941
canonical
ensembl
ENSRNOG00000010853
resolver
ensembl
ENSRNOG00055014663
resolver
ensembl
ENSRNOG00060018361
resolver
ensembl
ENSRNOG00065024127
resolver
ensp
ENSRNOP00000045255
resolver
ensp
ENSRNOP00000073551
resolver
ensp
ENSRNOP00055020610
resolver
ensp
ENSRNOP00060025640
resolver
ensp
ENSRNOP00065033852
resolver
enst
ENSRNOT00000051883
resolver
enst
ENSRNOT00000082487
resolver
enst
ENSRNOT00055025208
resolver
enst
ENSRNOT00060031572
resolver
enst
ENSRNOT00065041441
resolver
genesymbol
Chrna7
resolver
genesymbol_syn
Acra7
resolver
uniprot
A0A140TAF8
resolver
uniprot
Q53YK2
resolver
uniprot
Q5UMH9
resolver
uniprot_entry
A0A140TAF8_RAT
resolver
uniprot_entry
ACHA7_RAT
resolver
uniprot_entry
Q5UMH9_RAT
resolver
uniprot_sec
Q53YK2
resolver
activity_regulation
ACTIVITY REGULATION: Activated by a myriad of ligands such as acetylcholine, cytisine, nicotine, choline and epibatidine (PubMed:17510177, PubMed:22250215). Oligomeric amyloid-beta protein 42 activates specifially CHRNA7:CHRNB2 nAchRs. Activity is modulated by positive allosteric modulators (PAMs), such as flavonoids, with a wide range of chemical diversity, pharmacological sensitivity and efficacy. AChR activity is inhibited by the antagonists alpha-conotoxons RgIA, ImI and ImII, small disulfide-constrained peptides from cone snails (PubMed:25740413). Alpha-conotoxin PnIC selectively inhibits CHRNA7:CHRNB2 over CHRNA7 homopentamer (By similarity). {ECO:0000250|UniProtKB:P36544, ECO:0000269|PubMed:17510177, ECO:0000269|PubMed:22250215, ECO:0000269|PubMed:25740413}.
uniprot
proteins
amino_acid_sequence
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
uniprot
proteins
function
FUNCTION: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:17510177). CHRNA7 forms homopentameric neuronal acetylcholine receptors abundantly expressed in the central nervous system, characterized by fast desensitization and high calcium permeability. Also forms heteropentamers with CHRNB2, mainly expressed in basal forebrain cholinergic neurons (By similarity). Involved in the modulation of calcium-dependent signaling pathways and influences the release of neurotransmitters, including dopamine, glutamate and GABA (PubMed:17510177). Also expressed in non-neuronal cells such as immune cells like lymphocytes, monocytes and macrophages. In T cells, activation induces metabotropic signaling that results in an increase of intracellular Ca2+ concentrations, independent of ionotropic receptor functions (PubMed:17709503). In macrophages, required for acetylcholine-mediated inhibition of TNF and other inflammatory cytokine release. Once activated by acetylcholine, nicotine or other agonists, selectively inhibits production of pro-inflammatory cytokines while leaving anti-inflammatory cytokines undisturbed. Stimulates the cholinergic anti-inflammatory pathway, controlling inflammation by inhibiting NFKB nuclear translocation and activating the JAK2-STAT3 pathway, independently of ion channel activity (By similarity). Also expressed in the urothelium where it modulates reflex bladder activity by increasing intracellular calcium through internal stores and decreasing basal ATP release (PubMed:22250215). {ECO:0000250|UniProtKB:P36544, ECO:0000269|PubMed:17510177, ECO:0000269|PubMed:17709503, ECO:0000269|PubMed:22250215}.
uniprot
proteins
mass_dalton
56503
uniprot
proteins
mutagenesis
MUTAGEN 81; /note="S->T: 10-fold more potently inhibited by the alpha-conotoxin RgIA."; /evidence="ECO:0000269|PubMed:25740413"; MUTAGEN 141; /note="L->D: No change in inhibition by the alpha-conotoxin RgIA."; /evidence="ECO:0000269|PubMed:25740413"; MUTAGEN 433; /note="L->A: Abolishes dependency on RIC3 for functional expression."; /evidence="ECO:0000269|PubMed:15927954"; MUTAGEN 435; /note="K->A: No effect on dependency on RIC3 for functional expression."; /evidence="ECO:0000269|PubMed:15927954"; MUTAGEN 440; /note="V->A: Impairs dependency on RIC3 for functional expression."; /evidence="ECO:0000269|PubMed:15927954"; MUTAGEN 445; /note="N->A: Slightly impairs dependency on RIC3 for functional expression."; /evidence="ECO:0000269|PubMed:15927954"; MUTAGEN 446; /note="R->A: Impairs dependency on RIC3 for functional expression."; /evidence="ECO:0000269|PubMed:15927954"; MUTAGEN 447; /note="F->A: Impairs dependency on RIC3 for functional expression."; /evidence="ECO:0000269|PubMed:15927954"; MUTAGEN 448; /note="R->A: Impairs dependency on RIC3 for functional expression."; /evidence="ECO:0000269|PubMed:15927954
uniprot
proteins
post_translational_modification
PTM: Glycosylations at Asn-46, Asn-90 and Asn-133 are essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to the cell membrane. {ECO:0000250|UniProtKB:P49582}.
uniprot
proteins
protein_family
Acetylcholine receptor (TC 1.A.9.1) subfamily
uniprot
proteins
protein_family
Alpha-7/CHRNA7 sub-subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
15927954
uniprot
proteins
pubmed
16120769
uniprot
proteins
pubmed
17510177
uniprot
proteins
pubmed
17709503
uniprot
proteins
pubmed
22250215
uniprot
proteins
pubmed
25740413
uniprot
proteins
pubmed
27559150
uniprot
proteins
pubmed
7678857
uniprot
proteins
sequence_length
502
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:17510177}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:15927954}; Multi-pass membrane protein {ECO:0000255}. Note=RIC3 promotes its trafficking to the cell membrane (PubMed:15927954). TMEM35A/NACHO promotes its trafficking to the cell membrane (By similarity). {ECO:0000250|UniProtKB:P49582, ECO:0000269|PubMed:15927954}.
uniprot
proteins
transmembrane_region
TRANSMEM 234..254; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 262..282; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 295..315; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins