TGFBR3
entrez
7049
canonical
uniprot
Q03167
canonical
ensembl
ENSG00000069702
resolver
ensp
ENSP00000212355
resolver
ensp
ENSP00000359426
resolver
ensp
ENSP00000432638
resolver
ensp
ENSP00000436127
resolver
ensp
ENSP00000538477
resolver
genesymbol
TGFBR3
resolver
hgnc
HGNC:11774
resolver
uniprot
A0A0A8KWK3
resolver
uniprot
A0AUW8
resolver
uniprot
A8K5N0
resolver
uniprot
B9EG88
resolver
uniprot
Q5T2T4
resolver
uniprot
Q5U731
resolver
uniprot
Q9UGI2
resolver
uniprot_entry
A0A0A8KWK3_HUMAN
resolver
uniprot_entry
TGBR3_HUMAN
resolver
uniprot_sec
A0AUW8
resolver
uniprot_sec
A8K5N0
resolver
uniprot_sec
B9EG88
resolver
uniprot_sec
Q5T2T4
resolver
uniprot_sec
Q5U731
resolver
uniprot_sec
Q9UGI2
resolver
amino_acid_sequence
MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA
uniprot
proteins
function
FUNCTION: Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis (PubMed:12958365, PubMed:19416857). Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5 (PubMed:18184661). Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking (PubMed:19726563). Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin (PubMed:22562249). By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B (PubMed:19416857, PubMed:19325136). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (By similarity). Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization (PubMed:19416857). Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway (By similarity). {ECO:0000250|UniProtKB:P26342, ECO:0000269|PubMed:18184661, ECO:0000269|PubMed:19325136, ECO:0000269|PubMed:19416857, ECO:0000269|PubMed:19726563, ECO:0000269|PubMed:22562249, ECO:0000269|PubMed:34910520}.; FUNCTION: (Microbial infection) May act as a receptor for human cytomegalovirus in different cell types by interacting with HCMV trimer composed of GO, GH and GL. {ECO:0000269|PubMed:33626330}.
uniprot
proteins
mass_dalton
93499
uniprot
proteins
mutagenesis
MUTAGEN 840; /note="T->A: Partial loss of phosphorylation by TGFBR2."; /evidence="ECO:0000269|PubMed:12958365, ECO:0000269|PubMed:19416857
uniprot
proteins
post_translational_modification
PTM: Extensively modified by glycosaminoglycan groups (GAG).; PTM: Phosphorylated in the cytoplasmic domain by the type II receptor TGFBR2 at THR-840 to mediate recruitment of ARRB2 and subsequent internalization of TGFBR2 and TGFBR3. {ECO:0000269|PubMed:11323414, ECO:0000269|PubMed:12958365}.
uniprot
proteins
pubmed
10944857
uniprot
proteins
pubmed
11323414
uniprot
proteins
pubmed
12958365
uniprot
proteins
pubmed
1333192
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16982625
uniprot
proteins
pubmed
18184661
uniprot
proteins
pubmed
19325136
uniprot
proteins
pubmed
19416857
uniprot
proteins
pubmed
19726563
uniprot
proteins
pubmed
21871877
uniprot
proteins
pubmed
22562249
uniprot
proteins
pubmed
33626330
uniprot
proteins
pubmed
34910520
uniprot
proteins
sequence_length
851
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19416857, ECO:0000269|PubMed:19726563, ECO:0000269|PubMed:22562249}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:P26342}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P26342}. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix. {ECO:0000250|UniProtKB:P26342}.
uniprot
proteins
transmembrane_region
TRANSMEM 788..809; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins