L3MBTL1
entrez
26013
canonical
uniprot
Q9Y468
canonical
ensembl
ENSG00000185513
resolver
ensp
ENSP00000362226
resolver
ensp
ENSP00000362227
resolver
ensp
ENSP00000398516
resolver
ensp
ENSP00000402107
resolver
ensp
ENSP00000410139
resolver
ensp
ENSP00000415971
resolver
ensp
ENSP00000497566
resolver
enst
ENST00000373134
resolver
enst
ENST00000418998
resolver
enst
ENST00000434666
resolver
enst
ENST00000649917
resolver
genesymbol
L3MBTL1
resolver
genesymbol_syn
KIAA0681
resolver
genesymbol_syn
L3MBT
resolver
genesymbol_syn
L3MBTL
resolver
hgnc
HGNC:15905
resolver
uniprot
A0A0A0MRR4
resolver
uniprot
A0A3B3ISS0
resolver
uniprot
A0A3F2YNZ1
resolver
uniprot
B0QYN5
resolver
uniprot
B4DRC9
resolver
uniprot
E1P5W7
resolver
uniprot
Q5H8Y8
resolver
uniprot
Q5H8Y9
resolver
uniprot
Q8IUV7
resolver
uniprot
Q9H1E6
resolver
uniprot
Q9H1G5
resolver
uniprot
Q9UG06
resolver
uniprot
Q9UJB9
resolver
uniprot
Q9Y4C9
resolver
uniprot_entry
A0A0A0MRR4_HUMAN
resolver
uniprot_entry
A0A3B3ISS0_HUMAN
resolver
uniprot_entry
A0A3F2YNZ1_HUMAN
resolver
uniprot_entry
B0QYN5_HUMAN
resolver
uniprot_entry
LMBL1_HUMAN
resolver
uniprot_sec
B4DRC9
resolver
uniprot_sec
E1P5W7
resolver
uniprot_sec
Q5H8Y8
resolver
uniprot_sec
Q5H8Y9
resolver
uniprot_sec
Q8IUV7
resolver
uniprot_sec
Q9H1E6
resolver
uniprot_sec
Q9H1G5
resolver
uniprot_sec
Q9UG06
resolver
uniprot_sec
Q9UJB9
resolver
uniprot_sec
Q9Y4C9
resolver
amino_acid_sequence
MHLVAGDSPGSGPHLPATAFIIPASSATLGLPSSALDVSCFPREPIHVGAPEQVAGCEPVSATVLPQLSAGPASSSTSTVRLLEWTEAAAPPPGGGLRFRISEYKPLNMAGVEQPPSPELRQEGVTEYEDGGAPAGDGEAGPQQAEDHPQNPPEDPNQDPPEDDSTCQCQACGPHQAAGPDLGSSNDGCPQLFQERSVIVENSSGSTSASELLKPMKKRKRREYQSPSEEESEPEAMEKQEEGKDPEGQPTASTPESEEWSSSQPATGEKKECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDNFCWEKYLEETGASAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLGPREPSSASPGGCPPLSYRSLPHTRTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSEASARKKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQTLTPDVVHQSLFMSALSAHPDRSLSVCWEQHCKLLPGVAGISASTVAKWTIDEVFGFVQTLTGCEDQARLFKDEARIVRVTHVSGKTLVWTVAQLGDLVCSDHLQEGKGILETGVHSLLCSLPTHLLAKLSFASDSQY
uniprot
proteins
function
FUNCTION: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. {ECO:0000269|PubMed:17540172, ECO:0000269|PubMed:18408754, ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:20870725}.
uniprot
proteins
mass_dalton
92297
uniprot
proteins
mutagenesis
MUTAGEN 316; /note="D->N: Does not affect binding to monomethylated and dimethylated peptides."; /evidence="ECO:0000269|PubMed:17540172"; MUTAGEN 340; /note="F->A: Does not affect binding to monomethylated and dimethylated peptides."; /evidence="ECO:0000269|PubMed:17540172"; MUTAGEN 423; /note="D->A: Abolishes binding to monomethylated and dimethylated peptides."; /evidence="ECO:0000269|PubMed:17540172, ECO:0000269|PubMed:18026117, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:20870725"; MUTAGEN 423; /note="D->N: Strongly impairs binding to monomethylated and dimethylated peptides. Abolishes binding to p53/TP53 monomethylated at 'Lys-382'."; /evidence="ECO:0000269|PubMed:17540172, ECO:0000269|PubMed:18026117, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:20870725"; MUTAGEN 426; /note="N->A: Abolishes binding to monomethylated and dimethylated peptides."; /evidence="ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:20870725"; MUTAGEN 426; /note="N->Q: Strongly impairs binding to monomethylated and dimethylated peptides. Abolishes binding to p53/TP53 monomethylated at 'Lys-382'."; /evidence="ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:20870725"; MUTAGEN 431; /note="C->F,R: Strongly impairs binding to monomethylated and dimethylated peptides."; /evidence="ECO:0000269|PubMed:18026117"; MUTAGEN 447; /note="F->A: Abolishes binding to monomethylated and dimethylated peptides. Abolishes binding to p53/TP53 monomethylated at 'Lys-382'."; /evidence="ECO:0000269|PubMed:17540172, ECO:0000269|PubMed:20870725"; MUTAGEN 450; /note="W->L: Abolishes binding to p53/TP53 monomethylated at 'Lys-382'."; /evidence="ECO:0000269|PubMed:20870725"; MUTAGEN 454; /note="Y->L: Abolishes binding to p53/TP53 monomethylated at 'Lys-382'."; /evidence="ECO:0000269|PubMed:20870725"; MUTAGEN 527; /note="D->N: Does not affect binding to monomethylated and dimethylated peptides."; /evidence="ECO:0000269|PubMed:17540172"; MUTAGEN 551; /note="F->A: Does not affect binding to monomethylated and dimethylated peptides."; /evidence="ECO:0000269|PubMed:17540172
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated in a VCP/p97-dependent way following DNA damage, leading to its removal from DNA damage sites, promoting accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited to DNA damage sites. {ECO:0000269|PubMed:22120668}.
uniprot
proteins
pubmed
10445843
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12588862
uniprot
proteins
pubmed
12842041
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15123827
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17540172
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18026117
uniprot
proteins
pubmed
18042461
uniprot
proteins
pubmed
18408754
uniprot
proteins
pubmed
20870719
uniprot
proteins
pubmed
20870725
uniprot
proteins
pubmed
22120668
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
840
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10445843}. Note=Excluded from the nucleolus. Does not colocalize with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex.
uniprot
proteins