ITIH2
entrez
3698
canonical
uniprot
P19823
canonical
ensembl
ENSG00000151655
resolver
ensp
ENSP00000351190
resolver
ensp
ENSP00000569811
resolver
ensp
ENSP00000569812
resolver
enst
ENST00000358415
resolver
enst
ENST00000899752
resolver
enst
ENST00000899753
resolver
genesymbol
ITIH2
resolver
genesymbol_syn
IGHEP2
resolver
hgnc
HGNC:6167
resolver
uniprot
Q14659
resolver
uniprot
Q15484
resolver
uniprot
Q5T986
resolver
uniprot_entry
ITIH2_HUMAN
resolver
uniprot_sec
Q14659
resolver
uniprot_sec
Q15484
resolver
uniprot_sec
Q5T986
resolver
amino_acid_sequence
MKRLTCFFICFFLSEVSGFEIPINGLSEFVDYEDLVELAPGKFQLVAENRRYQRSLPGESEEMMEEVDQVTLYSYKVQSTITSRMATTMIQSKVVNNSPQPQNVVFDVQIPKGAFISNFSMTVDGKTFRSSIKEKTVGRALYAQARAKGKTAGLVRSSALDMENFRTEVNVLPGAKVQFELHYQEVKWRKLGSYEHRIYLQPGRLAKHLEVDVWVIEPQGLRFLHVPDTFEGHFDGVPVISKGQQKAHVSFKPTVAQQRICPNCRETAVDGELVVLYDVKREEKAGELEVFNGYFVHFFAPDNLDPIPKNILFVIDVSGSMWGVKMKQTVEAMKTILDDLRAEDHFSVIDFNQNIRTWRNDLISATKTQVADAKRYIEKIQPSGGTNINEALLRAIFILNEANNLGLLDPNSVSLIILVSDGDPTVGELKLSKIQKNVKENIQDNISLFSLGMGFDVDYDFLKRLSNENHGIAQRIYGNQDTSSQLKKFYNQVSTPLLRNVQFNYPHTSVTDVTQNNFHNYFGGSEIVVAGKFDPAKLDQIESVITATSANTQLVLETLAQMDDLQDFLSKDKHADPDFTRKLWAYLTINQLLAERSLAPTAAAKRRITRSILQMSLDHHIVTPLTSLVIENEAGDERMLADAPPQDPSCCSGALYYGSKVVPDSTPSWANPSPTPVISMLAQGSQVLESTPPPHVMRVENDPHFIIYLPKSQKNICFNIDSEPGKILNLVSDPESGIVVNGQLVGAKKPNNGKLSTYFGKLGFYFQSEDIKIEISTETITLSHGSSTFSLSWSDTAQVTNQRVQISVKKEKVVTITLDKEMSFSVLLHRVWKKHPVNVDFLGIYIPPTNKFSPKAHGLIGQFMQEPKIHIFNERPGKDPEKPEASMEVKGQKLIITRGLQKDYRTDLVFGTDVTCWFVHNSGKGFIDGHYKDYFVPQLYSFLKRP
uniprot
proteins
function
FUNCTION: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
uniprot
proteins
mass_dalton
106463
uniprot
proteins
post_translational_modification
PTM: Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage. {ECO:0000250}.; PTM: N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. {ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:7682553, ECO:0000269|PubMed:9425062, ECO:0000269|PubMed:9677337}.; PTM: Phosphorylated by FAM20C in the extracellular medium. {ECO:0000269|PubMed:26091039}.
uniprot
proteins
protein_family
ITIH family
uniprot
proteins
pubmed
12754519
uniprot
proteins
pubmed
1384548
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22171320
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2446322
uniprot
proteins
pubmed
2450046
uniprot
proteins
pubmed
2462430
uniprot
proteins
pubmed
2476436
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
3663330
uniprot
proteins
pubmed
7504674
uniprot
proteins
pubmed
7513643
uniprot
proteins
pubmed
7516184
uniprot
proteins
pubmed
7682553
uniprot
proteins
pubmed
9425062
uniprot
proteins
pubmed
9677337
uniprot
proteins
sequence_length
946
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins