CAMK2B
entrez
816
canonical
uniprot
Q13554
canonical
ensembl
ENSG00000058404
resolver
ensp
ENSP00000258682
resolver
ensp
ENSP00000326375
resolver
ensp
ENSP00000326427
resolver
ensp
ENSP00000326518
resolver
ensp
ENSP00000326544
resolver
ensp
ENSP00000351542
resolver
ensp
ENSP00000379096
resolver
ensp
ENSP00000379098
resolver
ensp
ENSP00000397937
resolver
ensp
ENSP00000566877
resolver
ensp
ENSP00000566880
resolver
ensp
ENSP00000566881
resolver
ensp
ENSP00000566882
resolver
ensp
ENSP00000566883
resolver
ensp
ENSP00000566888
resolver
ensp
ENSP00000566891
resolver
ensp
ENSP00000566899
resolver
ensp
ENSP00000566900
resolver
ensp
ENSP00000566904
resolver
ensp
ENSP00000613371
resolver
ensp
ENSP00000613372
resolver
ensp
ENSP00000613382
resolver
ensp
ENSP00000613383
resolver
ensp
ENSP00000613397
resolver
ensp
ENSP00000613407
resolver
ensp
ENSP00000613408
resolver
ensp
ENSP00000675177
resolver
ensp
ENSP00000718773
resolver
ensp
ENSP00000718782
resolver
genesymbol
CAMK2B
resolver
genesymbol_syn
CAM2
resolver
genesymbol_syn
CAMK2
resolver
genesymbol_syn
CAMKB
resolver
hgnc
HGNC:1461
resolver
uniprot
A4D2K0
resolver
uniprot
A4D2K1
resolver
uniprot
A4D2K2
resolver
uniprot
A4D2K3
resolver
uniprot
A4D2K4
resolver
uniprot
A4D2K5
resolver
uniprot
A4D2K6
resolver
uniprot
B7Z1Z6
resolver
uniprot
O95437
resolver
uniprot
O95438
resolver
uniprot
O95599
resolver
uniprot
Q9UGH7
resolver
uniprot
Q9UGH8
resolver
uniprot
Q9UGH9
resolver
uniprot
Q9UNX0
resolver
uniprot
Q9UNX7
resolver
uniprot
Q9UP00
resolver
uniprot
Q9Y5N4
resolver
uniprot
Q9Y6F4
resolver
uniprot_entry
B7Z1Z6_HUMAN
resolver
uniprot_entry
KCC2B_HUMAN
resolver
uniprot_sec
A4D2K0
resolver
uniprot_sec
A4D2K1
resolver
uniprot_sec
A4D2K2
resolver
uniprot_sec
A4D2K3
resolver
uniprot_sec
A4D2K4
resolver
uniprot_sec
A4D2K5
resolver
uniprot_sec
A4D2K6
resolver
uniprot_sec
O95437
resolver
uniprot_sec
O95438
resolver
uniprot_sec
O95599
resolver
uniprot_sec
Q9UGH7
resolver
uniprot_sec
Q9UGH8
resolver
uniprot_sec
Q9UGH9
resolver
uniprot_sec
Q9UNX0
resolver
uniprot_sec
Q9UNX7
resolver
uniprot_sec
Q9UP00
resolver
uniprot_sec
Q9Y5N4
resolver
uniprot_sec
Q9Y6F4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity. {ECO:0000269|PubMed:14722083}.
uniprot
proteins
amino_acid_sequence
MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVRRGSGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSPALLGPLSSPSPRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, autosomal dominant 54 (MRD54) [MIM:617799]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:29560374}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}.
uniprot
proteins
mass_dalton
72678
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state. {ECO:0000269|PubMed:14722083, ECO:0000269|PubMed:16690701}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10819240
uniprot
proteins
pubmed
10858498
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14722083
uniprot
proteins
pubmed
15294044
uniprot
proteins
pubmed
15312654
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16690701
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18817731
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19996366
uniprot
proteins
pubmed
21529938
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29100089
uniprot
proteins
pubmed
29560374
uniprot
proteins
pubmed
31930741
uniprot
proteins
pubmed
9060999
uniprot
proteins
sequence_length
666
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21529938}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:21529938}; Peripheral membrane protein {ECO:0000269|PubMed:21529938}; Cytoplasmic side {ECO:0000269|PubMed:21529938}. Synapse {ECO:0000250|UniProtKB:P08413}. Note=In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.
uniprot
proteins