Slc14a2
entrez
54302
canonical
uniprot
Q62668
canonical
ensembl
ENSRNOG00000061714
resolver
ensp
ENSRNOP00000068708
resolver
ensp
ENSRNOP00000073854
resolver
ensp
ENSRNOP00000074116
resolver
enst
ENSRNOT00000079899
resolver
genesymbol
Slc14a2
resolver
genesymbol_syn
Ut2
resolver
uniprot
A0A0G2JTG8
resolver
uniprot
Q9R1Y7
resolver
uniprot
Q9WTT8
resolver
uniprot
Q9Z2R3
resolver
uniprot_entry
A0A0G2JTG8_RAT
resolver
uniprot_entry
UT2_RAT
resolver
uniprot_sec
Q9R1Y7
resolver
uniprot_sec
Q9WTT8
resolver
uniprot_sec
Q9Z2R3
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform 1]: Inhibited by phloretin (PubMed:8958221). Activated by vasopressin, forskolin, 3-isobutyl-1-methylxanthine (IBMX) and cAMP (PubMed:16959825). {ECO:0000269|PubMed:16959825, ECO:0000269|PubMed:8958221}.; ACTIVITY REGULATION: [Isoform 2]: Inhibited by phloretin. {ECO:0000269|PubMed:11029290}.; ACTIVITY REGULATION: [Isoform 3]: Inhibited by urea analogs and phloretin and activated by forskolin. {ECO:0000269|PubMed:10215321, ECO:0000269|PubMed:11181411}.; ACTIVITY REGULATION: [Isoform 4]: Inhibited by phloretin and activated by forskolin. {ECO:0000269|PubMed:10215321}.
uniprot
proteins
amino_acid_sequence
MSDHPLKEMSDNNRSPPLPEPLSSRYKLYESELSSPTWPSSSQDTHPALPLLEMPEEKDLRSSDEDSHIVKIEKPNERSKRRESELPRRASAGRGAFSLFQAVSYLTGDMKECKNWLKDKPLVLQFLDWVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQDRSAIASGLHGYNGMLVGLLVAVFSEKLDYYWWLLFPVTFASMACPVISSALSTVFAKWDLPVFTLPFNIALTLYLAATGHYNLFFPTTLVKPASSAPNITWSEIEMPLLLQTIPVGVGQVYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVLSCVAIGGMFYVLTWQTHLLALVCALFCAYTGAALSNMMAVVGVPPGTWAFCLSTLTFLLLTSNNPGIHKLPLSKVTYPEANRIYFLTAKRSDEQKPPNGGGGEQSHGGGQRKAEEGSETVFPRRKSVFHIEWSSIRRRSKVFGKSEHQERQTKEPLPYLYRKPTVELLDLNTMEESSEIKVETNTTRTTWIQSSMIAGGKRVSKALSYITGEMKECGEGLKDKSPVFQFLDWVLRGTSQVMFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGLHGYNGVLVGLLMAVFSDKGNYYWWLLLPVIVMSMTCPILSSALSTVFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTKLLQPAVTTPNITWSDVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLVALFVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPGIYKLPLSKVTYPEANRIYFLSQEKNRRASMITKYQAYDVS
uniprot
proteins
function
FUNCTION: [Isoform 1]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism. {ECO:0000269|PubMed:16959825, ECO:0000269|PubMed:8958221}.; FUNCTION: [Isoform 2]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism. {ECO:0000269|PubMed:11029290, ECO:0000269|PubMed:7657826}.; FUNCTION: [Isoform 3]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism. {ECO:0000269|PubMed:10215321, ECO:0000269|PubMed:11181411}.; FUNCTION: [Isoform 4]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism. {ECO:0000269|PubMed:10215321}.
uniprot
proteins
mass_dalton
101896
uniprot
proteins
protein_family
Urea transporter family
uniprot
proteins
pubmed
10215321
uniprot
proteins
pubmed
11029290
uniprot
proteins
pubmed
11181411
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
16959825
uniprot
proteins
pubmed
17702749
uniprot
proteins
pubmed
7657826
uniprot
proteins
pubmed
8958221
uniprot
proteins
sequence_length
929
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Apical cell membrane {ECO:0000269|PubMed:16959825}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:16959825}; Multi-pass membrane protein {ECO:0000255}. Note=Vasopressin increases expression in the cell membrane. {ECO:0000269|PubMed:16959825}.
uniprot
proteins
transmembrane_region
TRANSMEM 133..155; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 162..179; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 184..204; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 212..232; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 310..330; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 349..371; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 378..399; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 400..420; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 609..629; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 647..667; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 675..695; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 704..724; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 773..793; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 812..832; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 841..861; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 863..883; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins