Nucb1
entrez
84595
canonical
uniprot
Q63083
canonical
ensembl
ENSRNOG00000020889
resolver
ensp
ENSRNOP00000028390
resolver
ensp
ENSRNOP00000075192
resolver
enst
ENSRNOT00000028390
resolver
enst
ENSRNOT00000079633
resolver
genesymbol
Nucb1
resolver
genesymbol_syn
Nuc
resolver
uniprot
A0A0G2K9Z3
resolver
uniprot
A0A8L2UKK1
resolver
uniprot
P97623
resolver
uniprot
Q497A4
resolver
uniprot_entry
A0A0G2K9Z3_RAT
resolver
uniprot_entry
A0A8L2UKK1_RAT
resolver
uniprot_entry
NUCB1_RAT
resolver
uniprot_sec
P97623
resolver
uniprot_sec
Q497A4
resolver
amino_acid_sequence
MPTSVPRGAPFLLLPPLLMLSAVLAVPVDRAAPHQEDNQATETPDTGLYYHRYLQEVINVLETDGHFREKLQAANAEDIKSGKLSQELDFVSHNVRTKLDELKRQEVSRLRMLLKAKMDAKQEPNLQVDHMNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLQEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGETAEGWKTVEMYPAYTEEELKRFEEELAAREAELNARAQRLSQETEALGRSQDRLEAQKRELQQAVLQMEQRKQQQQEQSAPPSQPDGQLQFRADTGDAPVPAPAGDQKDVPASEKKVPEQPPVLPQLDSQHL
uniprot
proteins
function
FUNCTION: Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (PubMed:7890746). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (PubMed:21653697). {ECO:0000269|PubMed:21653697, ECO:0000269|PubMed:7890746}.
uniprot
proteins
mass_dalton
53507
uniprot
proteins
mutagenesis
MUTAGEN 313; /note="L->A: Decreased binding to GNAI3. Further decrease in binding to GNAI3 and loss of GNAI3 activation; when associated with A-317."; /evidence="ECO:0000269|PubMed:21653697"; MUTAGEN 316; /note="F->A: Decreased binding to GNAI3 and impaired GNAI3 activation."; /evidence="ECO:0000269|PubMed:21653697"; MUTAGEN 317; /note="L->A: Decreased binding to GNAI3. Further decrease in binding to GNAI3 and loss of GNAI3 activation; when associated with A-313."; /evidence="ECO:0000269|PubMed:21653697
uniprot
proteins
protein_family
Nucleobindin family
uniprot
proteins
pubmed
10639138
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
21653697
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7890746
uniprot
proteins
pubmed
9647645
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10639138, ECO:0000269|PubMed:9647645}; Peripheral membrane protein {ECO:0000269|PubMed:9647645}; Lumenal side {ECO:0000269|PubMed:9647645}. Cytoplasm {ECO:0000269|PubMed:10639138, ECO:0000269|PubMed:9647645}. Secreted {ECO:0000269|PubMed:7890746}. Note=A small fraction of the protein may be cytoplasmic. In bone at least part of it is found in the extracellular matrix and in the culture medium of calvaria explants. {ECO:0000269|PubMed:7890746, ECO:0000269|PubMed:9647645}.
uniprot
proteins