CHPF
entrez
79586
canonical
uniprot
Q8IZ52
canonical
ensembl
ENSG00000123989
resolver
ensp
ENSP00000243776
resolver
ensp
ENSP00000445571
resolver
genesymbol
CHPF
resolver
genesymbol_syn
CSS2
resolver
hgnc
HGNC:24291
resolver
uniprot
B4DXU0
resolver
uniprot
Q6UXD6
resolver
uniprot
Q7L4G1
resolver
uniprot
Q9H0F8
resolver
uniprot
Q9H618
resolver
uniprot_entry
CHSS2_HUMAN
resolver
uniprot_sec
B4DXU0
resolver
uniprot_sec
Q6UXD6
resolver
uniprot_sec
Q7L4G1
resolver
uniprot_sec
Q9H0F8
resolver
uniprot_sec
Q9H618
resolver
amino_acid_sequence
MRASLLLSVLRPAGPVAVGISLGFTLSLLSVTWVEEPCGPGPPQPGDSELPPRGNTNAARRPNSVQPGAEREKPGAGEGAGENWEPRVLPYHPAQPGQAAKKAVRTRYISTELGIRQRLLVAVLTSQTTLPTLGVAVNRTLGHRLERVVFLTGARGRRAPPGMAVVTLGEERPIGHLHLALRHLLEQHGDDFDWFFLVPDTTYTEAHGLARLTGHLSLASAAHLYLGRPQDFIGGEPTPGRYCHGGFGVLLSRMLLQQLRPHLEGCRNDIVSARPDEWLGRCILDATGVGCTGDHEGVHYSHLELSPGEPVQEGDPHFRSALTAHPVRDPVHMYQLHKAFARAELERTYQEIQELQWEIQNTSHLAVDGDQAAAWPVGIPAPSRPASRFEVLRWDYFTEQHAFSCADGSPRCPLRGADRADVADVLGTALEELNRRYHPALRLQKQQLVNGYRRFDPARGMEYTLDLQLEALTPQGGRRPLTRRVQLLRPLSRVEILPVPYVTEASRLTVLLPLAAAERDLAPGFLEAFATAALEPGDAAAALTLLLLYEPRQAQRVAHADVFAPVKAHVAELERRFPGARVPWLSVQTAAPSPLRLMDLLSKKHPLDTLFLLAGPDTVLTPDFLNRCRMHAISGWQAFFPMHFQAFHPAVAPPQGPGPPELGRDTGRFDRQAASEACFYNSDYVAARGRLAAASEQEEELLESLDVYELFLHFSSLHVLRAVEPALLQRYRAQTCSARLSEDLYHRCLQSVLEGLGSRTQLAMLLFEQEQGNST
uniprot
proteins
function
FUNCTION: Non-catalytic component of CHSY1-CHPF2 and CHSY3-CHPF2 chondroitin sulfate synthase complexes. CHPF associates with catalytically active chondroitin synthases (CHSY1/3) within heterodimeric complexes. Plays an essential role for the formation of a stable and functional chondroitin sulfate polymerase complexes. {ECO:0000269|PubMed:12716890, ECO:0000269|PubMed:12761225, ECO:0000269|PubMed:41298522}.; FUNCTION: [Isoform 2]: May facilitate PRKN transport into the mitochondria. In collaboration with PRKN, may enhance cell viability and protect cells from oxidative stress. {ECO:0000269|PubMed:22082830}.
uniprot
proteins
mass_dalton
85467
uniprot
proteins
protein_family
Chondroitin N-acetylgalactosaminyltransferase family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12716890
uniprot
proteins
pubmed
12761225
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
22082830
uniprot
proteins
pubmed
41298522
uniprot
proteins
sequence_length
775
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:22082830}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytosol {ECO:0000269|PubMed:22082830}. Mitochondrion {ECO:0000269|PubMed:22082830}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion matrix {ECO:0000269|PubMed:22082830}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..34; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins