P06300
uniprot
P06300
canonical
amino_acid_sequence
MAWSRLMLAACLLVIPSEVAADCLSLCSLCAVRTQDGPHPINPLICSLECQDLVPPSEEWETCRGFWSFLTLTASGLHGKDDLENEVALEEGYTALTKLLEPLLKELEKGQLLTSVSEEKLRGLSSRFGNGRESELLGTDLMNDEAAQAGTLHFNEEDLRKQAKRYGGFLRKYPKRSSEMTGDEDRGQDGDQVGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQENPNTYSEDLDV
uniprot
proteins
function
FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). {ECO:0000250}.; FUNCTION: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin (By similarity). {ECO:0000250}.; FUNCTION: Leumorphin has a typical opioid activity and may have anti-apoptotic effect. {ECO:0000250}.
uniprot
proteins
mass_dalton
28079
uniprot
proteins
post_translational_modification
PTM: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
uniprot
proteins
protein_family
Opioid neuropeptide precursor family
uniprot
proteins
pubmed
16181412
uniprot
proteins
pubmed
2628741
uniprot
proteins
pubmed
2862869
uniprot
proteins
pubmed
2874472
uniprot
proteins
pubmed
2893267
uniprot
proteins
pubmed
3858883
uniprot
proteins
pubmed
8276115
uniprot
proteins
sequence_length
248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins