Bsg
entrez
12215
canonical
uniprot
P18572
canonical
ensembl
ENSMUSG00000023175
resolver
ensp
ENSMUSP00000070751
resolver
ensp
ENSMUSP00000136487
resolver
genesymbol
Bsg
resolver
uniprot
Q6LDB0
resolver
uniprot
Q7TSC0
resolver
uniprot_entry
BASI_MOUSE
resolver
uniprot_sec
Q6LDB0
resolver
uniprot_sec
Q7TSC0
resolver
amino_acid_sequence
MAAALLLALAFTLLSGQGACAAAGFLKAPLSQERWAGGSVVLHCEAVGSPIPEIQWWFEGNAPNDSCSQLWDGARLDRVHIHAAYRQHAASSLSVDGLTAEDTGTYECRASSDPDRNHLTRPPRVKWVRAQASVVVLEPGTIQTSVQEVNSKTQLTCSLNSSGVDIVGHRWMRGGKVLQEDTLPDLHTKYIVDADDRSGEYSCIFLPEPVGRSEINVEGPPRIKVGKKSEHSSEGELAKLVCKSDASYPPITDWFWFKTSDTGEEEAITNSTEANGKYVVVSTPEKSQLTISNLDVNVDPGTYVCNATNAQGTTRETISLRVRSRMAALWPFLGIVAEVLVLVTIIFIYEKRRKPDQTLDEDDPGAAPLKGSGTHMNDKDKNVRQRNAT
uniprot
proteins
function
FUNCTION: [Isoform 1]: Essential for normal retinal maturation and development (PubMed:10967074, PubMed:11273674, PubMed:11853760). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). {ECO:0000269|PubMed:10967074, ECO:0000269|PubMed:11273674, ECO:0000269|PubMed:11853760, ECO:0000269|PubMed:25957687}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity). Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane (PubMed:12601063). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity). Plays an important role in spermatogenesis; mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids (PubMed:11882021, PubMed:23727514). {ECO:0000250|UniProtKB:P35613, ECO:0000269|PubMed:11882021, ECO:0000269|PubMed:12601063, ECO:0000269|PubMed:23727514}.; FUNCTION: Plays a role in neurite outgrowth. {ECO:0000269|PubMed:37158588}.
uniprot
proteins
mass_dalton
42445
uniprot
proteins
post_translational_modification
PTM: [Isoform 1]: N-glycosylated. {ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:19656770, ECO:0000269|PubMed:25957687}.; PTM: [Isoform 2]: N-glycosylated (PubMed:12558975, PubMed:23727514). During spermatogenesis, probably deglycosylated during epididymal transit (PubMed:11882021). {ECO:0000269|PubMed:11882021, ECO:0000269|PubMed:12558975, ECO:0000269|PubMed:23727514}.
uniprot
proteins
pubmed
10967074
uniprot
proteins
pubmed
11273674
uniprot
proteins
pubmed
11853760
uniprot
proteins
pubmed
11882021
uniprot
proteins
pubmed
12211060
uniprot
proteins
pubmed
12558975
uniprot
proteins
pubmed
12601063
uniprot
proteins
pubmed
12939332
uniprot
proteins
pubmed
15037112
uniprot
proteins
pubmed
15095333
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
2032306
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21792931
uniprot
proteins
pubmed
2361961
uniprot
proteins
pubmed
23727514
uniprot
proteins
pubmed
25957687
uniprot
proteins
pubmed
2697642
uniprot
proteins
pubmed
27503893
uniprot
proteins
pubmed
37158588
uniprot
proteins
pubmed
8333335
uniprot
proteins
pubmed
8576084
uniprot
proteins
sequence_length
389
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:11273674, ECO:0000269|PubMed:25957687}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Photoreceptor inner segment {ECO:0000269|PubMed:11853760, ECO:0000269|PubMed:25957687}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:25957687}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:12601063}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P35613}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}. Basolateral cell membrane {ECO:0000250|UniProtKB:P35613}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P26453}.
uniprot
proteins
transmembrane_region
TRANSMEM 326..349; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins