ORC3
entrez
23595
canonical
uniprot
Q9UBD5
canonical
ensembl
ENSG00000135336
resolver
ensp
ENSP00000257789
resolver
ensp
ENSP00000376586
resolver
ensp
ENSP00000444695
resolver
ensp
ENSP00000520852
resolver
ensp
ENSP00000561586
resolver
ensp
ENSP00000561587
resolver
ensp
ENSP00000659952
resolver
ensp
ENSP00000687330
resolver
ensp
ENSP00000687332
resolver
ensp
ENSP00000732431
resolver
ensp
ENSP00000767357
resolver
ensp
ENSP00000767358
resolver
ensp
ENSP00000799035
resolver
enst
ENST00000850561
resolver
genesymbol
ORC3
resolver
genesymbol_syn
LATHEO
resolver
genesymbol_syn
ORC3L
resolver
hgnc
HGNC:8489
resolver
uniprot
A0ABB0MVJ1
resolver
uniprot
A2A2T5
resolver
uniprot
B4E025
resolver
uniprot
Q13565
resolver
uniprot
Q53GY6
resolver
uniprot
Q5T159
resolver
uniprot
Q6IUY7
resolver
uniprot
Q86TN5
resolver
uniprot
Q9UG44
resolver
uniprot
Q9UNT6
resolver
uniprot_entry
A0ABB0MVJ1_HUMAN
resolver
uniprot_entry
ORC3_HUMAN
resolver
uniprot_sec
A2A2T5
resolver
uniprot_sec
B4E025
resolver
uniprot_sec
Q13565
resolver
uniprot_sec
Q53GY6
resolver
uniprot_sec
Q5T159
resolver
uniprot_sec
Q6IUY7
resolver
uniprot_sec
Q86TN5
resolver
uniprot_sec
Q9UG44
resolver
uniprot_sec
Q9UNT6
resolver
amino_acid_sequence
MATSSMSKGCFVFKPNSKKRKISLPIEDYFNKGKNEPEDSKLRFETYQLIWQQMKSENERLQEELNKNLFDNLIEFLQKSHSGFQKNSRDLGGQIKLREIPTAALVLGVNVTDHDLTFGSLTEALQNNVTPYVVSLQAKDCPDMKHFLQKLISQLMDCCVDIKSKEEESVHVTQRKTHYSMDSLSSWYMTVTQKTDPKMLSKKRTTSSQWQSPPVVVILKDMESFATKVLQDFIIISSQHLHEFPLILIFGIATSPIIIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQFPFKINEKVLQVLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVLCCNLPEAKRRINFLSNNQCENIRRLPSFRRYVEKQASEKQVALLTNERYLKEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKYPLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLDETKEEEDASGSQPKGLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAHALREHLNAAPRIALHTALNNPYYYLKNEALKSEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTWGGC
uniprot
proteins
function
FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:31160578}.
uniprot
proteins
mass_dalton
82254
uniprot
proteins
post_translational_modification
PTM: Multi-mono-ubiquitinated by OBI1; ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle. {ECO:0000269|PubMed:31160578}.
uniprot
proteins
protein_family
ORC3 family
uniprot
proteins
pubmed
10402192
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12909626
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17716973
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22427655
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
31160578
uniprot
proteins
sequence_length
711
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31160578}. Chromosome {ECO:0000269|PubMed:31160578}.
uniprot
proteins