Aatf
entrez
114512
canonical
uniprot
Q9QYW0
canonical
ensembl
ENSRNOG00000002778
resolver
ensembl
ENSRNOG00055026875
resolver
ensembl
ENSRNOG00060025055
resolver
ensembl
ENSRNOG00065019443
resolver
ensp
ENSRNOP00000000258
resolver
ensp
ENSRNOP00055038093
resolver
ensp
ENSRNOP00060035961
resolver
ensp
ENSRNOP00065026206
resolver
enst
ENSRNOT00000000258
resolver
enst
ENSRNOT00055046442
resolver
enst
ENSRNOT00060043410
resolver
enst
ENSRNOT00065032781
resolver
genesymbol
Aatf
resolver
uniprot_entry
AATF_RAT
resolver
amino_acid_sequence
MAELQPLALQLEQLLNPRPREADPEADPEEATRARVIDRFDEGEEEEDDLPVSSIRKLAPVSLLDTDKRYSGKTTSRKAWKEDHWDQTLPSSSDNEIPDEGGSEAGDSEGLEELSEDVEEDLEDNEIPDEGGSEDGDSEGLEEEISEDVEEDLEGEDEEDREEDRNSEDDGVVMAFSGVKVSEEVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPVFKDKGGPEFASALKNSHKALKALLRSLVDLQEELLFQYPDTRYLVKGTKPNAESEEISSEDDELVGEKKKQRKAPPKRKLEMEDYPSFMAKRSADFTVYRNRTLQKWHDKTKLASGKLGKGFGAFERSILTQIDHILMDKERLLRRTQTKRSAYRVLGKPEPVPEPVAETLPGEPESLPQVPANAHLKDLDEEIFDDDDFYHQLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIRKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTAMNDEARTELYRSLFGQLNRLDADHGQ
uniprot
proteins
function
FUNCTION: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation (By similarity). May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation. {ECO:0000250, ECO:0000269|PubMed:14761944}.
uniprot
proteins
mass_dalton
59497
uniprot
proteins
protein_family
AATF family
uniprot
proteins
pubmed
10580117
uniprot
proteins
pubmed
14761944
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10580117}.
uniprot
proteins