Eed
entrez
13626
canonical
uniprot
Q921E6
canonical
ensembl
ENSMUSG00000030619
resolver
ensp
ENSMUSP00000102853
resolver
genesymbol
Eed
resolver
uniprot
P97462
resolver
uniprot_entry
EED_MOUSE
resolver
uniprot_sec
P97462
resolver
amino_acid_sequence
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
uniprot
proteins
function
FUNCTION: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain. {ECO:0000250|UniProtKB:O75530, ECO:0000269|PubMed:11479595, ECO:0000269|PubMed:12370779, ECO:0000269|PubMed:12627233, ECO:0000269|PubMed:12649488, ECO:0000269|PubMed:12689588, ECO:0000269|PubMed:15516932, ECO:0000269|PubMed:15916951, ECO:0000269|PubMed:16415857, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17259173, ECO:0000269|PubMed:17997413, ECO:0000269|PubMed:18201968, ECO:0000269|PubMed:9234727, ECO:0000269|PubMed:9742080}.
uniprot
proteins
mass_dalton
50198
uniprot
proteins
mutagenesis
MUTAGEN 193; /note="I->N: Hypomorphic allele. Abrogates interaction with EZH2 and impairs transcriptional repression."; /evidence="ECO:0000269|PubMed:9234727, ECO:0000269|PubMed:9742080"; MUTAGEN 196; /note="L->P: Null allele. Abrogates interaction with EZH2 and impairs transcriptional repression."; /evidence="ECO:0000269|PubMed:17259173, ECO:0000269|PubMed:9234727, ECO:0000269|PubMed:9742080"; MUTAGEN 246; /note="L->E: Abrogates interaction with EZH2."; /evidence="ECO:0000269|PubMed:17937919"; MUTAGEN 315; /note="L->E: Impairs interaction with EZH2."; /evidence="ECO:0000269|PubMed:17937919"; MUTAGEN 316; /note="G->A: Impairs interaction with EZH2."; /evidence="ECO:0000269|PubMed:17937919
uniprot
proteins
post_translational_modification
PTM: Methylated. Binding to histone H1 'Lys-26' promotes mono-, di-, and trimethylation of internal lysines (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
WD repeat ESC family
uniprot
proteins
pubmed
11479595
uniprot
proteins
pubmed
12123576
uniprot
proteins
pubmed
12370779
uniprot
proteins
pubmed
12627233
uniprot
proteins
pubmed
12649488
uniprot
proteins
pubmed
12689588
uniprot
proteins
pubmed
14671313
uniprot
proteins
pubmed
14752160
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15516932
uniprot
proteins
pubmed
15684044
uniprot
proteins
pubmed
15916951
uniprot
proteins
pubmed
16007070
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16224021
uniprot
proteins
pubmed
16415857
uniprot
proteins
pubmed
16618801
uniprot
proteins
pubmed
17259173
uniprot
proteins
pubmed
17937919
uniprot
proteins
pubmed
17997413
uniprot
proteins
pubmed
18201968
uniprot
proteins
pubmed
19026780
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
20144788
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23970558
uniprot
proteins
pubmed
8805699
uniprot
proteins
pubmed
8984348
uniprot
proteins
pubmed
9234727
uniprot
proteins
pubmed
9742080
uniprot
proteins
sequence_length
441
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Localizes to the inactive X chromosome in cells of the early embryo and in stem cells of the extraembryonic trophectoderm lineage. Recruitment to the inactive X-chromosome requires XIST.
uniprot
proteins