LRWD1
entrez
71735
canonical
uniprot
Q8BUI3
canonical
ensembl
ENSMUSG00000029703
resolver
ensp
ENSMUSP00000006301
resolver
enst
ENSMUST00000006301
resolver
genesymbol
LRWD1
resolver
genesymbol_syn
Orca
resolver
uniprot
D3Z2P9
resolver
uniprot
Q3TIG2
resolver
uniprot
Q8BKI3
resolver
uniprot
Q9DBW4
resolver
uniprot_entry
LRWD1_MOUSE
resolver
uniprot_sec
D3Z2P9
resolver
uniprot_sec
Q3TIG2
resolver
uniprot_sec
Q8BKI3
resolver
uniprot_sec
Q9DBW4
resolver
amino_acid_sequence
MAPLTPQLLLQRGRPKTDKLGKIQSLNLSGLQLLSEHLDPNLLGRLKKLRELDLSNNLLETLPANLGLSHLRILRCTNNQLGDVTALHQFPELEELNLEGNPFLTVSDNLKVSFLLPKLRKVNGKDTASTCSQVENLDRELMDRVTAHWQKFIATVSPEEETDKVRADFMRSAVRDVCYGPESLIEFTQWRVRMIAEELVASGGAQVQDAKVPVEHPQAAGASKFRAREVASKRPGKDPVTLPPSKRVRALPPAQAEGSPMGADGGQAALHLEPLHFLQCHSRNNSPKDLETQLWACAFEPAREEGHSRATSQTVATCGGEAVCVIDCQTGLVLHKYKVPGEEFFSVAWTALTVVTQAGHKKRWNMLAAAGLRGMVRLLHVRAGFCCSVIRAHKKAIATLCFSPSHETHLFTASYDKRIILWDIGVPNQDYKFQASQLLTLNCGSVPLRLCPVATCPDDFLLAGCEGGCYCWDVRLDQPQKQRVCEVNFIFSEDSKVSGQRVDGLAFVNEDVVASKGSGQGTIYLWSWSQTWAGRGRQSVLPVVILVRLQWSPTNLAYFSLSTCPGKNLVLCGDEEGSVWIYDVEHLLKEPPQATTLQPPTQILKWPQPTALGQPVTKTMINTVVANAAFTYLTALTDSNIVSIWRRC
uniprot
proteins
function
FUNCTION: Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation (By similarity). Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. {ECO:0000250, ECO:0000269|PubMed:22427655}.
uniprot
proteins
mass_dalton
71594
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination leading to proteasomal degradation. Ubiquitination occurs within the WD repeats at the end of the G1 phase. Ubiquitination may be catalyzed by the CUL4-DDB1 E3 ubiquitin-protein ligase complex and other E3 ligases (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
LRWD1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17074343
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20180869
uniprot
proteins
pubmed
22427655
uniprot
proteins
sequence_length
648
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UFC0}. Chromosome, centromere {ECO:0000250|UniProtKB:Q9UFC0}. Chromosome, telomere {ECO:0000250|UniProtKB:Q9UFC0}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20180869}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9UFC0}. Note=Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3. {ECO:0000250|UniProtKB:Q9UFC0}.
uniprot
proteins