Lin28b
entrez
380669
canonical
uniprot
Q45KJ6
canonical
ensembl
ENSMUSG00000063804
resolver
ensp
ENSMUSP00000078361
resolver
genesymbol
Lin28b
resolver
uniprot
Q3UZC6
resolver
uniprot
Q3V444
resolver
uniprot_entry
LN28B_MOUSE
resolver
uniprot_sec
Q3UZC6
resolver
uniprot_sec
Q3V444
resolver
amino_acid_sequence
MAEGGASKGEEPEKLPGLAEDEPQVLHGTGHCKWFNVRMGFGFISMISREGNPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSPKGLESIRVTGPGGSPCLGSERRPKGKTLQKRKPKGDRCYNCGGLDHHAKECSLPPQPKKCHYCQSIMHMVANCPHKLAAQLPASSQGRQEAESQPCSSAAPREVGGGHGCTVLFPQEVKSEMAEHSDRSPQEVSSTKAFAAIGEQNKKGPLIQKRKKT
uniprot
proteins
function
FUNCTION: Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. Does not act on pri-miR21. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation. This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent. Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop (By similarity). Mediates MYC-induced let-7 repression (PubMed:19211792). When overexpressed, may stimulate growth of carcinoma cell lines (By similarity). {ECO:0000250|UniProtKB:Q6ZN17, ECO:0000269|PubMed:19211792}.
uniprot
proteins
mass_dalton
26903
uniprot
proteins
protein_family
Lin-28 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19211792
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q6ZN17}.
uniprot
proteins