Trim55
entrez
365751
canonical
uniprot
Q5PQN5
canonical
ensembl
ENSRNOG00000012723
resolver
ensembl
ENSRNOG00065019641
resolver
ensp
ENSRNOP00000017125
resolver
ensp
ENSRNOP00000084028
resolver
ensp
ENSRNOP00065026470
resolver
enst
ENSRNOT00000017125
resolver
enst
ENSRNOT00000094830
resolver
enst
ENSRNOT00065033105
resolver
genesymbol
Trim55
resolver
genesymbol_syn
Murf2
resolver
genesymbol_syn
Rnf29
resolver
uniprot
A0A8I6A0E8
resolver
uniprot_entry
A0A8I6A0E8_RAT
resolver
uniprot_entry
TRI55_RAT
resolver
amino_acid_sequence
MSTSLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQHNLCRKCASDIFQASNPYLPTRGGTTVASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESTRPEKKLDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAPLTHVFQRQKSELSDGIAVLVGSNDRVQGVISQLEDTCKTIEECCRKQKQDLCEKFDHLYSILEERKTEMTQAITRTQEEKLEHVRTLIRKYSDHLENVSKLVESGIQFMDEPEMAVFLQNAKTLLQKITEASKAFQMEKIEQGYEIMNNFTVNLNREEKIIREIDFSREEEDEDDEGEVDEEGEGEDAVEVEEAENVQVASSGEEETLEKAAEPSELAAEIQAASGPLLASSPDSVSSLPPAADVLVTQGEVVPTDSQQTTQSETSGPSAAETADPLFYPSWYKGQSRKMISNPPHTPGGEGLSQIGPSAAEDSSVQSAEVAEAAANEQAAVSGKESSSTAATSQIGFEASSPQGQAAALGSGGGADSEPARHVFSFSWLNSLNE
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays an important role in regulating cardiac development and contractility, muscle growth, metabolism, and fiber-type differentiation. Acts as a critical factor that regulates cardiomyocyte size during development in concert with TRIM63 by regulating E2F1-mediated gene expression. Plays a role in apoptosis induction in cardiomyocytes by promoting ubiquitination of the DUSP1 phosphatase. Promotes non-canonical NF-kappa-B signaling and B-cell-mediated immune responses by mediating NFKB2 'Lys-48'-linked ubiquitination and processing. In turn, NFKB2 is further processed by valosin-containing protein/VCP, an ATPase that mediates ubiquitin-dependent protein degradation by the proteasome. May play a role in preventing macrophages from producing inflammatory factors and migrating by down-regulating the level of nuclear NF-kappa-B subunit RELA. Also modifies PPARG via polyubiquitination and accelerates PPARG proteasomal degradation to inhibit its activity. {ECO:0000250|UniProtKB:G3X8Y1, ECO:0000250|UniProtKB:Q9BYV6}.
uniprot
proteins
mass_dalton
59980
uniprot
proteins
post_translational_modification
PTM: Targeted for degradation through the proteasomal and lysosomal pathways in the presence of SUMO3. {ECO:0000250|UniProtKB:Q9BYV6}.
uniprot
proteins
pubmed
12414993
uniprot
proteins
pubmed
15199100
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15802564
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
545
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:G3X8Y1}. Cytoplasm {ECO:0000250|UniProtKB:G3X8Y1}. Note=TLR4 signaling pathway promotes nuclear translocation. {ECO:0000250|UniProtKB:G3X8Y1}.
uniprot
proteins