Slc3a2
entrez
17254
canonical
uniprot
P10852
canonical
ensembl
ENSMUSG00000010095
resolver
ensp
ENSMUSP00000010239
resolver
ensp
ENSMUSP00000130194
resolver
ensp
ENSMUSP00000146016
resolver
enst
ENSMUST00000206598
resolver
genesymbol
Slc3a2
resolver
genesymbol_syn
Mdu1
resolver
uniprot
A0A0U1RPK4
resolver
uniprot
G3UWA6
resolver
uniprot
Q54AH5
resolver
uniprot_entry
4F2_MOUSE
resolver
uniprot_entry
A0A0U1RPK4_MOUSE
resolver
uniprot_sec
G3UWA6
resolver
uniprot_sec
Q54AH5
resolver
amino_acid_sequence
MSQDTEVDMKDVELNELEPEKQPMNAADGAAAGEKNGLVKIKVAEDETEAGVKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPVQRWWHKGALYRIGDLQAFVGRDAGGIAGLKSHLEYLSTLKVKGLVLGPIHKNQKDEINETDLKQINPTLGSQEDFKDLLQSAKKKSIHIILDLTPNYQGQNAWFLPAQADIVATKMKEALSSWLQDGVDGFQFRDVGKLMNAPLYLAEWQNITKNLSEDRLLIAGTESSDLQQIVNILESTSDLLLTSSYLSNSTFTGERTESLVTRFLNATGSQWCSWSVSQAGLLADFIPDHLLRLYQLLLFTLPGTPVFSYGDELGLQGALPGQPAKAPLMPWNESSIFHIPRPVSLNMTVKGQNEDPGSLLTQFRRLSDLRGKERSLLHGDFHALSSSPDLFSYIRHWDQNERYLVVLNFRDSGRSARLGASNLPAGISLPASAKLLLSTDSARQSREEDTSLKLENLSLNPYEGLLLQFPFVA
uniprot
proteins
function
FUNCTION: Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heterodimers to the plasma membrane. Forms heterodimers with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10734121, PubMed:11011012, PubMed:9915839). Heterodimers function as amino acid exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids. Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (By similarity). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocate neutral amino acids with broad specificity, thyroid hormones and L-DOPA. SLC3A2 is essential for the plasma membrane localization, stability, and transport activity of SLC7A5 and SLC7A8. When associated with LAPTM4B, the SLC3A2/SLC7A5 heterodimer is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (By similarity). {ECO:0000250|UniProtKB:P08195, ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10734121, ECO:0000269|PubMed:11011012, ECO:0000269|PubMed:9915839}.
uniprot
proteins
mass_dalton
58337
uniprot
proteins
mutagenesis
MUTAGEN 103; /note="C->S: Loss of interchain disulfide bond. No effect on guidance of SLC7A5 to the plasma membrane."; /evidence="ECO:0000269|PubMed:9915839
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-300 or Ser-302 and on Ser-420 by ecto-protein kinases favors heterotypic cell-cell interactions. {ECO:0000250|UniProtKB:P08195}.; PTM: N-glycosylated; N-glycosylation is crucial for trafficking and stability of SLC3A2 to the plasma membrane. SLC3A2 surface retention and endocytosis are precisely balanced by N-glycosylation. {ECO:0000250|UniProtKB:P08195}.
uniprot
proteins
protein_family
SLC3A transporter family
uniprot
proteins
pubmed
10574970
uniprot
proteins
pubmed
10734121
uniprot
proteins
pubmed
11011012
uniprot
proteins
pubmed
12927796
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2928113
uniprot
proteins
pubmed
30958588
uniprot
proteins
pubmed
9915839
uniprot
proteins
sequence_length
526
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P08195}. Cell membrane {ECO:0000269|PubMed:9915839}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P08195}. Cell junction {ECO:0000269|PubMed:9915839}. Lysosome membrane {ECO:0000250|UniProtKB:P08195}. Melanosome {ECO:0000250|UniProtKB:P08195}. Basolateral cell membrane {ECO:0000269|PubMed:10574970}. Note=Localized at the plasma membrane when associated with SLC7A5 or SLC7A8. Localized to the apical membrane of placental syncytiotrophoblastic cells. Recruited to lysosomes by LAPTM4B (By similarity). Located selectively at cell-cell adhesion sites (PubMed:9915839). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). {ECO:0000250|UniProtKB:P08195, ECO:0000250|UniProtKB:Q794F9, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:9915839}.
uniprot
proteins
transmembrane_region
TRANSMEM 76..99; /note="Helical; Signal-anchor for type II membrane protein
uniprot
proteins