CPSF7
entrez
79869
canonical
uniprot
Q8N684
canonical
ensembl
ENSG00000149532
resolver
ensp
ENSP00000345412
resolver
ensp
ENSP00000378352
resolver
ensp
ENSP00000397203
resolver
ensp
ENSP00000437860
resolver
ensp
ENSP00000529505
resolver
genesymbol
CPSF7
resolver
hgnc
HGNC:30098
resolver
uniprot
B3KU04
resolver
uniprot
B4DGF8
resolver
uniprot
C9K0Q4
resolver
uniprot
Q7Z3H9
resolver
uniprot
Q9H025
resolver
uniprot
Q9H9V1
resolver
uniprot_entry
B4DGF8_HUMAN
resolver
uniprot_entry
CPSF7_HUMAN
resolver
uniprot_sec
B3KU04
resolver
uniprot_sec
C9K0Q4
resolver
uniprot_sec
Q7Z3H9
resolver
uniprot_sec
Q9H025
resolver
uniprot_sec
Q9H9V1
resolver
amino_acid_sequence
MSEGVDLIDIYADEEFNQDPEFNNTDQIDLYDDVLTATSQPSDDRSSSTEPPPPVRQEPSPKPNNKTPAILYTYSGLRNRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRECVRVPRGGIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASAPYNHHGSRDSGPPPSTVSEAEFEDIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH
uniprot
proteins
function
FUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}.
uniprot
proteins
mass_dalton
52050
uniprot
proteins
post_translational_modification
PTM: Phosphorylated (PubMed:29276085). {ECO:0000269|PubMed:29276085}.; PTM: Asymmetrically dimethylated on arginine residues by PRMT1 (PubMed:20562214). {ECO:0000269|PubMed:20562214}.
uniprot
proteins
protein_family
RRM CPSF6/7 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17024186
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19864460
uniprot
proteins
pubmed
20562214
uniprot
proteins
pubmed
20695905
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23187700
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29276085
uniprot
proteins
pubmed
8626397
uniprot
proteins
sequence_length
471
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19864460, ECO:0000305|PubMed:20695905}. Cytoplasm {ECO:0000269|PubMed:19864460}. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460). {ECO:0000269|PubMed:19864460}.
uniprot
proteins