Crmp1
entrez
25415
canonical
uniprot
Q62950
canonical
ensembl
ENSRNOG00000004781
resolver
ensembl
ENSRNOG00055015576
resolver
ensembl
ENSRNOG00060017374
resolver
ensembl
ENSRNOG00065031836
resolver
ensp
ENSRNOP00000063671
resolver
ensp
ENSRNOP00000086765
resolver
ensp
ENSRNOP00055021573
resolver
ensp
ENSRNOP00060024162
resolver
ensp
ENSRNOP00065045197
resolver
enst
ENSRNOT00000065334
resolver
enst
ENSRNOT00000106933
resolver
enst
ENSRNOT00055026599
resolver
enst
ENSRNOT00060029953
resolver
enst
ENSRNOT00065054942
resolver
genesymbol
Crmp1
resolver
genesymbol_syn
Dpysl1
resolver
uniprot
A0A8I6A2Y7
resolver
uniprot
P70546
resolver
uniprot_entry
A0A8I6A2Y7_RAT
resolver
uniprot_entry
DPYL1_RAT
resolver
uniprot_sec
P70546
resolver
amino_acid_sequence
MSHQGKKSIPHITSDRLLIRGGRIINDDQSFYADVYLEDGLIKQIGENLIVPGGVKTIEANGRMVIPGGIDVNTYLQKPSQGMTSADDFFQGTRAALAGGTTMIIDHVVPEPGSSLLTSFEKWHEAADTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVNSFQVYMAYKDLYQMSDSQLYEAFTFLKGLGAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAIAIAGRINCPVYITKVMSKSAADIIALARKKGPLVFGEPIAASLGTDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYLTSLLACGDLQVTGSGHCPYSTAQKAVGKDNFTLIPEGVNGIEERMTVVWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKMKTLTAKSHKSTVEYNIFEGMECHGSPLVVISQGKIVFEDGNISVSKGMGRFIPRKPFPEHLYQRVRIRSKVFGLHSVSRGMYDGPVYEVPATPKHAAPAPSAKSSPSKHQPPPIRNLHQSNFSLSGAQIDDNNPRRTGHRIVAPPGGRSNITSLG
uniprot
proteins
function
FUNCTION: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in axon guidance (By similarity). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (By similarity). Involved in invasive growth and cell migration. May participate in cytokinesis (By similarity). {ECO:0000250|UniProtKB:P97427, ECO:0000250|UniProtKB:Q14194}.
uniprot
proteins
mass_dalton
62196
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-522 enhances CRMP1-mediated alteration of FLNA ternary structure and FLNA dissociation from F-actin. {ECO:0000250|UniProtKB:Q14194}.
uniprot
proteins
protein_family
Hydantoinase/dihydropyrimidinase family
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
25358863
uniprot
proteins
pubmed
8815901
uniprot
proteins
pubmed
9375656
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14194}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q14194}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q14194}. Cell projection, growth cone {ECO:0000250|UniProtKB:P97427}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P97427}. Perikaryon {ECO:0000250|UniProtKB:P97427}. Note=Associated with centrosomes and the mitotic spindle during metaphase (By similarity). Colocalizes with FLNA and tubulin in the central region of DRG neuron growth cone. Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity). {ECO:0000250|UniProtKB:P97427, ECO:0000250|UniProtKB:Q14194}.
uniprot
proteins