DRG2
entrez
1819
canonical
uniprot
P55039
canonical
ensembl
ENSG00000108591
resolver
ensp
ENSP00000225729
resolver
ensp
ENSP00000379076
resolver
enst
ENST00000225729
resolver
enst
ENST00000395726
resolver
genesymbol
DRG2
resolver
hgnc
HGNC:3030
resolver
uniprot
A8MZF9
resolver
uniprot
B2R8G5
resolver
uniprot
Q53Y50
resolver
uniprot
Q9BWB2
resolver
uniprot_entry
A8MZF9_HUMAN
resolver
uniprot_entry
DRG2_HUMAN
resolver
uniprot_sec
B2R8G5
resolver
uniprot_sec
Q53Y50
resolver
uniprot_sec
Q9BWB2
resolver
amino_acid_sequence
MGILEKISEIEKEIARTQKNKATEYHLGLLKAKLAKYRAQLLEPSKSASSKGEGFDVMKSGDARVALIGFPSVGKSTFLSLMTSTASEAASYEFTTLTCIPGVIEYKGANIQLLDLPGIIEGAAQGKGRGRQVIAVARTADVIIMMLDATKGEVQRSLLEKELESVGIRLNKHKPNIYFKPKKGGGISFNSTVTLTQCSEKLVQLILHEYKIFNAEVLFREDCSPDEFIDVIVGNRVYMPCLYVYNKIDQISMEEVDRLARKPNSVVISCGMKLNLDYLLEMLWEYLALTCIYTKKRGQRPDFTDAIILRKGASVEHVCHRIHRSLASQFKYALVWGTSTKYSPQRVGLTHTMEHEDVIQIVKK
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. {ECO:0000269|PubMed:29915238}.
uniprot
proteins
mass_dalton
40746
uniprot
proteins
mutagenesis
MUTAGEN 21; /note="K->A: Impairs JMJD7-mediated hydroxylation and ribonucleic acid binding."; /evidence="ECO:0000269|PubMed:29915238
uniprot
proteins
post_translational_modification
PTM: Hydroxylated (with S stereochemistry) at C-3 of Lys-21 by JMJD7; this modification hinders trypsin-catalyzed proteolysis in vitro. {ECO:0000269|PubMed:29915238, ECO:0000269|PubMed:35410347}.; PTM: Polyubiquitinated. {ECO:0000250|UniProtKB:Q9QXB9}.
uniprot
proteins
protein_family
OBG GTPase family
uniprot
proteins
protein_family
TRAFAC class OBG-HflX-like GTPase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
29915238
uniprot
proteins
pubmed
35410347
uniprot
proteins
pubmed
7929244
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29915238}. Cytoplasm {ECO:0000269|PubMed:29915238}.
uniprot
proteins