Sema4c
entrez
20353
canonical
uniprot
Q64151
canonical
ensembl
ENSMUSG00000026121
resolver
ensp
ENSMUSP00000110643
resolver
ensp
ENSMUSP00000141263
resolver
ensp
ENSMUSP00000141527
resolver
ensp
ENSMUSP00000142284
resolver
ensp
ENSMUSP00000165184
resolver
ensp
ENSMUSP00000165185
resolver
ensp
ENSMUSP00000165192
resolver
ensp
ENSMUSP00000165194
resolver
ensp
ENSMUSP00000165195
resolver
ensp
ENSMUSP00000165196
resolver
ensp
ENSMUSP00000361606
resolver
enst
ENSMUST00000114991
resolver
enst
ENSMUST00000191642
resolver
enst
ENSMUST00000191677
resolver
enst
ENSMUST00000195620
resolver
genesymbol
Sema4c
resolver
genesymbol_syn
S4c
resolver
genesymbol_syn
Semacl1
resolver
genesymbol_syn
Semai
resolver
uniprot_entry
SEM4C_MOUSE
resolver
amino_acid_sequence
MAPHWAVWLLAAGLWGLGIGAEMWWNLVPRKTVSSGELVTVVRRFSQTGIQDFLTLTLTEHSGLLYVGAREALFAFSVEALELQGAISWEAPAEKKIECTQKGKSNQTECFNFIRFLQPYNSSHLYVCGTYAFQPKCTYINMLTFTLDRAEFEDGKGKCPYDPAKGHTGLLVDGELYSATLNNFLGTEPVILRYMGTHHSIKTEYLAFWLNEPHFVGSAFVPESVGSFTGDDDKIYFFFSERAVEYDCYSEQVVARVARVCKGDMGGARTLQKKWTTFLKARLVCSAPDWKVYFNQLKAVHTLRGASWHNTTFFGVFQARWGDMDLSAVCEYQLEQIQQVFEGPYKEYSEQAQKWARYTDPVPSPRPGSCINNWHRDNGYTSSLELPDNTLNFIKKHPLMEDQVKPRLGRPLLVKKNTNFTHVVADRVPGLDGATYTVLFIGTGDGWLLKAVSLGPWIHMVEELQVFDQEPVESLVLSQSKKVLFAGSRSQLVQLSLADCTKYRFCVDCVLARDPYCAWNVNTSRCVATTSGRSGSFLVQHVANLDTSKMCNQYGIKKVRSIPKNITVVSGTDLVLPCHLSSNLAHAHWTFGSQDLPAEQPGSFLYDTGLQALVVMAAQSRHSGPYRCYSEEQGTRLAAESYLVAVVAGSSVTLEARAPLENLGLVWLAVVALGAVCLVLLLLVLSLRRRLREELEKGAKASERTLVYPLELPKEPASPPFRPGPETDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGGGRNSNANGYVRLQLGGEDRGGSGHPLPELADELRRKLQQRQPLPDSNPEESSV
uniprot
proteins
function
FUNCTION: Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. {ECO:0000269|PubMed:15811348, ECO:0000269|PubMed:17498836, ECO:0000269|PubMed:17554007, ECO:0000269|PubMed:21122816}.
uniprot
proteins
mass_dalton
92557
uniprot
proteins
mutagenesis
MUTAGEN 832; /note="S->A: Loss of the effect on myogenic differentiation; when associated with A-834. Loss of interaction with DLG4; when associated with A-833 and A-834."; /evidence="ECO:0000269|PubMed:11134026, ECO:0000269|PubMed:15811348"; MUTAGEN 833; /note="S->A: Loss of interaction with DLG4; when associated with A-832 and A-834."; /evidence="ECO:0000269|PubMed:11134026"; MUTAGEN 834; /note="V->A: Loss of the effect on myogenic differentiation; when associated with A-832. Loss of interaction with DLG4; when associated with A-832 and A-833."; /evidence="ECO:0000269|PubMed:11134026, ECO:0000269|PubMed:15811348
uniprot
proteins
protein_family
Semaphorin family
uniprot
proteins
pubmed
10318831
uniprot
proteins
pubmed
11134026
uniprot
proteins
pubmed
11162505
uniprot
proteins
pubmed
15811348
uniprot
proteins
pubmed
17498836
uniprot
proteins
pubmed
17554007
uniprot
proteins
pubmed
21122816
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7656991
uniprot
proteins
sequence_length
834
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic density membrane {ECO:0000269|PubMed:11134026}; Single-pass type I membrane protein {ECO:0000269|PubMed:11134026}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:11134026}; Single-pass type I membrane protein {ECO:0000269|PubMed:11134026}.
uniprot
proteins
transmembrane_region
TRANSMEM 665..685; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins