Kcnq5
entrez
226922
canonical
uniprot
Q9JK45
canonical
ensembl
ENSMUSG00000028033
resolver
ensp
ENSMUSP00000029667
resolver
ensp
ENSMUSP00000110955
resolver
ensp
ENSMUSP00000134076
resolver
enst
ENSMUST00000029667
resolver
enst
ENSMUST00000115300
resolver
enst
ENSMUST00000173404
resolver
genesymbol
Kcnq5
resolver
uniprot
E9Q9F1
resolver
uniprot
G3UYG5
resolver
uniprot
Q4QXS5
resolver
uniprot
Q8BSF6
resolver
uniprot_entry
E9Q9F1_MOUSE
resolver
uniprot_entry
G3UYG5_MOUSE
resolver
uniprot_entry
KCNQ5_MOUSE
resolver
uniprot_sec
Q4QXS5
resolver
uniprot_sec
Q8BSF6
resolver
activity_regulation
ACTIVITY REGULATION: Phosphatidylinositol-4,5-bisphosphate (PIP2) is essential to activate KCNQ5 channel by inducing the coupling of the voltage-sensing domain (VSD) and the pore-forming domain (PD) (By similarity). Calcium suppresses KCNQ5 channel current through calcium-bound CALM C-terminus (By similarity). Therefore CALM acts as calcium sensor that controls channel activity (By similarity). Zinc potentiates channel activity in a pH-dependent manner (PubMed:15963599). The activity is modulated by small changes in cell volume (PubMed:15963599). Activated by the anticonvulsant retigabine (PubMed:15963599). Inhibited by linopirdine and XE991 (PubMed:15963599). {ECO:0000250|UniProtKB:Q92508, ECO:0000250|UniProtKB:Q9NR82, ECO:0000269|PubMed:15963599}.
uniprot
proteins
amino_acid_sequence
MPRHHAGGEEGGAAGLWVRSGAAAAAGAGGGRPGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAAALGGGGGGLRESRRGKQGARMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFVYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKPVIDADTALGIDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQMTSDKKSREKITAEHETTDDPSMLARVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALTLASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLTRSASANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPMSQNDGSSVVATNNIANQISAAPKPAAPTTLQIPPPLSAIKHLSRPEPLLSNPTGLQESISDVTTCLVASKESVQFAQSNLTKDRSLRKSFDMGGETLLSVRPMVPKDLGKSLSVQNLIRSTEELNLQFSGSESSGSRGSQDFYPKWRESKLFITDEEVGAEETETDTFDGTPPPAGEAAFSSDSLRTGRSRSSQNICKTGDSTDALSLPHVKLN
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the voltage-gated potassium (Kv) channel broadly expressed in brain and skeletal muscle and involved in the regulation of neuronal excitability (PubMed:15963599). Associates with KCNQ3/Kv7.3 pore-forming subunit to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons (By similarity). Contributes, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current (PubMed:15963599). Also forms a functional channel with KCNQ1/Kv7.1 subunit that may contribute to vasoconstriction and hypertension. Channel may be selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) = Rb(+) > Cs(+) > Na(+) (By similarity). {ECO:0000250|UniProtKB:Q9NR82, ECO:0000269|PubMed:15963599}.
uniprot
proteins
mass_dalton
102258
uniprot
proteins
protein_family
KQT (TC 1.A.1.15) subfamily
uniprot
proteins
protein_family
Kv7.5/KCNQ5 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
15963599
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
933
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15963599}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 127..147; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 231..253; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 268..288; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 327..347; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins