Stn1
entrez
108689
canonical
uniprot
Q8K2X3
canonical
ensembl
ENSMUSG00000042694
resolver
ensp
ENSMUSP00000040944
resolver
ensp
ENSMUSP00000138727
resolver
ensp
ENSMUSP00000252649
resolver
enst
ENSMUST00000049369
resolver
enst
ENSMUST00000182808
resolver
genesymbol
Stn1
resolver
genesymbol_syn
Obfc1
resolver
uniprot
Q3TPH0
resolver
uniprot
Q3UXU8
resolver
uniprot
Q8C6I6
resolver
uniprot
S4R2P4
resolver
uniprot_entry
Q3UXU8_MOUSE
resolver
uniprot_entry
S4R2P4_MOUSE
resolver
uniprot_entry
STN1_MOUSE
resolver
uniprot_sec
Q3TPH0
resolver
uniprot_sec
Q8C6I6
resolver
amino_acid_sequence
MPQPCLLMECESSPREEEIPPLFWGLDPVFLAFAKLYIKDILEMKESQQVPGTYFYNGHPIRRVDIMGAVISVKERETFYSYGVDDATGVINCVCWKKLSNAESSSDPAILSTARELSMTSQLKKLQETIEQKTRIGIGDIIRVRGSVRMFREEREICANIYYKVDDPVWNMQIARMLELPKLYQKVYDQPFRNPALQEEEALNNKDNLDLAGLTSLLSEKIKEFLQEKKMQSFYQQELETVESLQSLASRPVTHSTGSDQVELKDSGTSGVAQRVFKNALQLLQEKGLVFQRDSGSDKLYYVTTKDKDLQQKIYHIIKEDCQKPNHMEKGCHLLHILNCVHLNLRWDLSKAVLQRVLELLEDQSDIVSTADHYYAAF
uniprot
proteins
function
FUNCTION: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22748632). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres. Promotes general replication start following replication-fork stalling implicating new origin firing. May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (By similarity). {ECO:0000250|UniProtKB:Q9H668, ECO:0000269|PubMed:19854130, ECO:0000269|PubMed:22748632}.
uniprot
proteins
mass_dalton
43486
uniprot
proteins
mutagenesis
MUTAGEN 96; /note="W->A: Impairs single-stranded DNA binding; when associated with A-151."; /evidence="ECO:0000269|PubMed:19119139"; MUTAGEN 151; /note="F->A: Impairs single-stranded DNA binding; when associated with A-96."; /evidence="ECO:0000269|PubMed:19119139
uniprot
proteins
protein_family
STN1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19119139
uniprot
proteins
pubmed
19648609
uniprot
proteins
pubmed
19854130
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22748632
uniprot
proteins
sequence_length
378
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19119139, ECO:0000269|PubMed:19854130}. Chromosome, telomere {ECO:0000269|PubMed:19854130}.
uniprot
proteins