Slc22a14
entrez
382113
canonical
uniprot
Q497L9
canonical
ensembl
ENSMUSG00000070280
resolver
ensp
ENSMUSP00000091289
resolver
ensp
ENSMUSP00000361719
resolver
enst
ENSMUST00000093775
resolver
genesymbol
Slc22a14
resolver
genesymbol_syn
Gm1128
resolver
uniprot_entry
S22AE_MOUSE
resolver
amino_acid_sequence
MKEDQNYKTAFGSQNSRDTHRHEISFPSQNWSLEMLLRRLKAIDARRDDKFASVMDAIGEFGTFQWRLVVLTFIPSILSTFFIFSHHFLLTAQRPYCNTSWILEVGPNLTEDEQLNLTLPRAPNGSFLTCLMYIPVPWDLDSIIHFGLNYTETCKFGWIYPFAHTRSLINEFDLVCGNEPNKENGLTVFLSGVLTGSLLFGFLSDKLGRYPIILLSLLGFLIFGFGTAFVSSFYQYLFFRFFVAQASVGYAICSVSLVMEWLVGEHRAQAVILQHSFLTIGVILLTGLAYKVVHWRLLCLLGGMPMFPLICNIWVLRESPRWLMVRGKVEEAKKVLCYAAEVNKKTIPLNLLNELQISGKKVAKASILDFCTNQHLFKVVLAIGCVWFTVSYISFTLNLKMNDFGLDVYFVQMVRSIVAVPARLCCIILLEYFGRKWALNLTLFLVTSMCLFLLFLPQEPKSTIILTLMLAEFSMAGTLSIFFIYTAELLPTVLRSTGLGMVSLAWVAGAISSVAIFKQTKTQLPIFFCCLCCVLALCFSSLVPETGSQSLRDSIEYNIRDSIEPKDRNKDVPMVIAEESMSDIVADSEVTNTTLNAVTFKPEENSLLNMTLEVPKMDLPVQSLKAQPP
uniprot
proteins
function
FUNCTION: Riboflavin transporter localized at the inner mitochondrial membrane of the spermatozoa midpiece, which is required for male fertility (PubMed:33882315). SLC22A14-mediated riboflavin transport is essential for spermatozoa energy generation and motility: riboflavin is the precursor of FMN and FAD, which are coenzymes of many enzymes in the TCA cycle (the citric acid cycle) in mitochondria (PubMed:33882315). Required for sperm motility and normal sperm flagellar structure (PubMed:27811987, PubMed:33882315). {ECO:0000269|PubMed:27811987, ECO:0000269|PubMed:33882315}.
uniprot
proteins
mass_dalton
71009
uniprot
proteins
mutagenesis
MUTAGEN 275; /note="H->A: Strongly reduced riboflavin transport; when associated with 391-A--A-394."; /evidence="ECO:0000269|PubMed:33882315"; MUTAGEN 391..394; /note="SYIS->AYIA: Strongly reduced riboflavin transport; when associated with A-275."; /evidence="ECO:0000269|PubMed:33882315
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27811987
uniprot
proteins
pubmed
33882315
uniprot
proteins
sequence_length
629
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:33882315}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:27811987}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the principle piece of the sperm tail. {ECO:0000269|PubMed:27811987}.
uniprot
proteins
transmembrane_region
TRANSMEM 68..88; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 184..204; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 210..230; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 270..290; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 296..316; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 379..399; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 410..430; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 437..457; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 464..484; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 497..517; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 524..544; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins