Trpm1
entrez
361586
canonical
uniprot
Q2WEA5
canonical
ensembl
ENSRNOG00000015829
resolver
ensp
ENSRNOP00000021262
resolver
genesymbol
Trpm1
resolver
uniprot
F1M9X0
resolver
uniprot
Q2WEA4
resolver
uniprot_entry
TRPM1_RAT
resolver
uniprot_sec
F1M9X0
resolver
uniprot_sec
Q2WEA4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by extracellular zinc ions. Inhibited by intracellular Mg(2+). Activated by the neuroactive steroid pregnenolone sulfate (By similarity). Negatively regulated by activation of GRM6 receptors in the ON-bipolar cells (By similarity). {ECO:0000250|UniProtKB:Q2TV84, ECO:0000250|UniProtKB:Q7Z4N2}.
uniprot
proteins
amino_acid_sequence
MGSMRKMSSSFKRGSIKSSTSGSQKGQKAWIEKTFCKRECIFVIPSTKDPNRCCCGQLTNQHIPPLPSVTPSSTAEDTKQGDAQSGKWSVSKHTQSYPTDSYGILEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQSFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGKSVVSHVGDALKDHSSKSRGRLCAIGIAPWGMVENKEDLVGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRQLEKHISLQKINTRLGQGVPVVGLVVEGGPNVVSIVLEYLREDPPVPVVVCDGSGRASDILSFAHKYCDEGGVINESLRDQLLVTIQKTFNYSKSQSHQLFAIIMECMKKKELVTVFRMGSEGQQDVEMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSLAPPVDTKVAEKEKKPPTATTKGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVNALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKSFRTLYNNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEECMAKALVACKLYKAMAHESSESELVDDISQDLDNNSKDFGQLAVELLDQSYKHDEQVAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILIPPTILFLEFRSYDDFSYQTSKENEDGKEKEEENVDANADAGSRKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSPQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISMFMVGAILRLQNQPYMGYGRVIYCVDIILWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDRKTRIHIYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIVMRLSGRCRKKREGDQEERDRGLKLFLSDEELKKLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERENFMKASLQTVDLRLSQLEELSGRMVGALENLAGIDRSDLIQARSRASSECEATYLLRQSSINSADGYSMYRYHFNGEELLFEEPALSTSPGTVFRKKTCSFRVKEEDVKSHLDQPSSLHHTPGPSPPATPGRSRLALDGPLSTELRPGLDPGISAGELDPRADFKSAEVAPSLNTANVASTQLTVESTVSHPLRESKLARYYPGDLNTYKTMKSRSFVYSEGRKLVRGLSNWGAEYSSIMDQTWNSAEWRCQVQRITRSRSTDIPYIVSEAASQDEFEDEHRESLLAPQISRSALTVSDRPEKENLLSVKPHQTLGFPCLRSRSLHGHPRSAKPSPSKLDRAGHASSTSNLAVMSDAPEGQNTQQEKGNPETEC
uniprot
proteins
function
FUNCTION: Constitutively open nonselective divalent cation-conducting channels which mediate the influx of Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization. Impermeable to zinc ions. In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions. Plays an essential role for the depolarizing photoresponse of retinal ON bipolar cells (By similarity). In the dark, tonic release of glutamate activates the G protein-coupled receptor for glutamate GRM6, its activation induces the release of G(o) protein and the beta-gamma G protein dimer. Both subunits can interact and inactivate the TRPM1 channel. A light onset, induces decrease in glutamate release and deactivation of GRM6 leading to channel opening and membrane depolarization (By similarity). May play a role in metastasis suppression (By similarity). {ECO:0000250|UniProtKB:Q2TV84, ECO:0000250|UniProtKB:Q7Z4N2}.
uniprot
proteins
mass_dalton
184523
uniprot
proteins
protein_family
LTrpC subfamily
uniprot
proteins
protein_family
TRPM1 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15856355
uniprot
proteins
sequence_length
1630
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7Z4N2}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q2TV84}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:Q2TV84}. Note=In ON-bipolar cells is intracellular and located predominantly in the ER, and not at the plasma membrane or Golgi apparatus. {ECO:0000250|UniProtKB:Q7Z4N2}.
uniprot
proteins
transmembrane_region
TRANSMEM 878..898; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 945..965; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 976..996; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1009..1029; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1108..1128; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1159..1179; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins