Lcn2
entrez
16819
canonical
uniprot
P11672
canonical
ensembl
ENSMUSG00000026822
resolver
ensp
ENSMUSP00000053962
resolver
enst
ENSMUST00000050785
resolver
genesymbol
Lcn2
resolver
uniprot
Q3UE34
resolver
uniprot_entry
NGAL_MOUSE
resolver
uniprot_sec
Q3UE34
resolver
amino_acid_sequence
MALSVMCLGLALLGVLQSQAQDSTQNLIPAPSLLTVPLQPDFRSDQFRGRWYVVGLAGNAVQKKTEGSFTMYSTIYELQENNSYNVTSILVRDQDQGCRYWIRTFVPSSRAGQFTLGNMHRYPQVQSYNVQVATTDYNQFAMVFFRKTSENKQYFKITLYGRTKELSPELKERFTRFAKSLGLKDDNIIFSVPTDQCIDN
uniprot
proteins
function
FUNCTION: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:15531878, PubMed:16446425). Can also bind siderophores from M.tuberculosis (By similarity). {ECO:0000250|UniProtKB:P80188, ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:15531878, ECO:0000269|PubMed:16377569, ECO:0000269|PubMed:16446425, ECO:0000269|PubMed:20550936}.
uniprot
proteins
mass_dalton
22875
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:21911364, ECO:0000269|PubMed:8687399}.
uniprot
proteins
protein_family
Calycin superfamily
uniprot
proteins
protein_family
Lipocalin family
uniprot
proteins
pubmed
12453413
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15531878
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16377569
uniprot
proteins
pubmed
16446425
uniprot
proteins
pubmed
1723819
uniprot
proteins
pubmed
1834059
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20550936
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21911364
uniprot
proteins
pubmed
2542864
uniprot
proteins
pubmed
30418175
uniprot
proteins
pubmed
8666241
uniprot
proteins
pubmed
8687399
uniprot
proteins
sequence_length
200
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:20550936, ECO:0000269|PubMed:8687399}. Cytoplasmic granule lumen {ECO:0000250|UniProtKB:P80188}. Cytoplasmic vesicle lumen {ECO:0000250|UniProtKB:P80188}. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized (PubMed:16377569). Releases the bound iron in the acidic lumen of cytoplasmic vesicles (By similarity). {ECO:0000250|UniProtKB:P80188, ECO:0000269|PubMed:16377569}.
uniprot
proteins