Evc
entrez
59056
canonical
uniprot
P57680
canonical
ensembl
ENSMUSG00000029122
resolver
ensp
ENSMUSP00000031005
resolver
ensp
ENSMUSP00000109791
resolver
ensp
ENSMUSP00000229082
resolver
ensp
ENSMUSP00000229085
resolver
ensp
ENSMUSP00000229086
resolver
ensp
ENSMUSP00000229087
resolver
genesymbol
Evc
resolver
uniprot
E9QPK2
resolver
uniprot_entry
EVC_MOUSE
resolver
uniprot_sec
E9QPK2
resolver
amino_acid_sequence
MTCTKDARLQLGREALQAAPTLLVPAVLLGGVLGLGLGLWLGCRASHLRARLQKDDRKRLLGSSEPPAQSLRDTGSQAKARRRQRETTRDEDAPEVCEPSLSGNITAFALKARVVYPINQKFRPLADGSSHPSLHENLTQAAAILPHLPHQPAEASPASSLGSLSQAGKEDGSSSSSMRSTYSDDRILQCAFLRVGSFPEILACESVDIDLCVCSLHLKDLLQVDTALRQEKHLMFIQILKACLLDFFPKKKPDDELCQKVLSKQEHDLEELEKGLQARLANTEMLGTGDSGYVSLADVERKERELSEQLIDNMGAFWKQMESIQPTLMDQFKCSSSKARQFMMTLTGRMIVAEGLLHDSQDLHVLDTLERTMGRSHLARMVEFLRTQIQEETKCRLAAISRGLELLTVQGQLSGRQKEELLTQQHKAFWEEAERFGREFTQRGKDLVQASQARQAEAAAELTQTQEEERRSFLADSQLTSDPGEFLKAFHEVLERQRLTRSDQEGDEDTRITEAMAALCQELYCSTMGTFQKFVDSLFLKTLPEVTSLPVAECETLRQQVQEQAARQLGQADRFRRRQWGLLCDLLEQDKRVWLEEGTLSTVLQRQLRDHHESTIHGVLSRFSGLSEESSRGILQGHELLLCSALRRLALRGTTITALAQMRLSGKKRLLQELHEQLALEQGVSPCLEEHQWQLLRALEARIQEEAARLEDEAQQTGLRLQQQLLAEAQEAGRLLQLHMERVIGQALLVHARNVASKGRTREKEDFKRTLVETVVESVYVTSTSVNRLVQAHYQAVGKLLQAHEEQLLQRLKTLQGERINAYKLWKKQEFSDPSLESQTADGTHGASQGVQQRMLSQQKRLLDQFTKHQQGRLNSQRQKAQELDQLQAQLETQLQEAEQTLISELSTLARVPLPENKPFSNKRGLPEKPVRTKRKKPPPREREDLGTPNDDHLALADHTTGPLSTTYSASPPIRVHSGGRLDQQDSEAGDGESTSKILQKGSNL
uniprot
proteins
function
FUNCTION: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (PubMed:17660199, PubMed:24582806). Involved in endochondral growth and skeletal development (PubMed:17660199). {ECO:0000269|PubMed:17660199, ECO:0000269|PubMed:24582806}.
uniprot
proteins
mass_dalton
113003
uniprot
proteins
pubmed
10700184
uniprot
proteins
pubmed
17660199
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21356043
uniprot
proteins
pubmed
24582806
uniprot
proteins
sequence_length
1005
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21356043}; Single-pass membrane protein {ECO:0000269|PubMed:21356043}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17660199}. Cell projection, cilium {ECO:0000269|PubMed:21356043}. Cell projection, cilium membrane {ECO:0000269|PubMed:21356043, ECO:0000269|PubMed:24582806}. Note=EVC2 is required for the localization of EVC at the base of primary cilia (PubMed:21356043). The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner (PubMed:24582806). {ECO:0000269|PubMed:21356043, ECO:0000269|PubMed:24582806}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins