Ren1
entrez
19701
canonical
uniprot
P06281
canonical
ensembl
ENSMUSG00000070645
resolver
ensp
ENSMUSP00000092135
resolver
enst
ENSMUST00000094556
resolver
genesymbol
Ren1
resolver
genesymbol_syn
Ren
resolver
genesymbol_syn
Ren-1
resolver
uniprot
P97911
resolver
uniprot
Q543E5
resolver
uniprot
Q62153
resolver
uniprot
Q62154
resolver
uniprot_entry
RENI1_MOUSE
resolver
uniprot_sec
P97911
resolver
uniprot_sec
Q543E5
resolver
uniprot_sec
Q62153
resolver
uniprot_sec
Q62154
resolver
activity_regulation
ACTIVITY REGULATION: Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. {ECO:0000250|UniProtKB:P00797}.
uniprot
proteins
amino_acid_sequence
MDRRRMPLWALLLLWSPCTFSLPTRTATFERIPLKKMPSVREILEERGVDMTRLSAEWGVFTKRPSLTNLTSPVVLTNYLNTQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMENGSDFTIHYGSGRVKGFLSQDSVTVGGITVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVGGVTPVFDHILSQGVLKEEVFSVYYNRGSHLLGGEVVLGGSDPQHYQGNFHYVSISKTDSWQITMKGVSVGSSTLLCEEGCAVVVDTGSSFISAPTSSLKLIMQALGAKEKRIEEYVVNCSQVPTLPDISFDLGGRAYTLSSTDYVLQYPNRRDKLCTLALHAMDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR
uniprot
proteins
ec_number
3.4.23.15
uniprot
proteins
function
FUNCTION: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. {ECO:0000269|PubMed:6370686}.
uniprot
proteins
mass_dalton
44343
uniprot
proteins
protein_family
Peptidase A1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2685761
uniprot
proteins
pubmed
2691339
uniprot
proteins
pubmed
6089205
uniprot
proteins
pubmed
6327270
uniprot
proteins
pubmed
6370686
uniprot
proteins
pubmed
6392850
uniprot
proteins
pubmed
9030738
uniprot
proteins
sequence_length
402
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9030738}. Membrane {ECO:0000250|UniProtKB:P00797}. Note=Associated to membranes via binding to ATP6AP2. {ECO:0000250|UniProtKB:P00797}.
uniprot
proteins