Epha8
entrez
13842
canonical
uniprot
O09127
canonical
ensembl
ENSMUSG00000028661
resolver
ensp
ENSMUSP00000030420
resolver
ensp
ENSMUSP00000287483
resolver
enst
ENSMUST00000030420
resolver
genesymbol
Epha8
resolver
genesymbol_syn
Eek
resolver
uniprot
A3KG07
resolver
uniprot_entry
EPHA8_MOUSE
resolver
uniprot_sec
A3KG07
resolver
amino_acid_sequence
MAPARARLSPALWVVTAAAAATCVSAGRGEVNLLDTSTIHGDWGWLTYPAHGWDSINEVDESFRPIHTYQVCNVMSPNQNNWLRTNWVPRDGARRVYAEIKFTLRDCNSIPGVLGTCKETFNLHYLESDRDLGASTQESQFLKIDTIAADESFTGADLGVRRLKLNTEVRGVGPLSKRGFYLAFQDIGACLAILSLRIYYKKCPAMVRNLAAFSEAVTGADSSSLVEVRGQCVRHSEERDTPKMYCSAEGEWLVPIGKCVCSAGYEERRDACMACELGFYKSAPGDQLCARCPPHSHSATPAAQTCRCDLSYYRAALDPPSAACTRPPSAPVNLISSVNGTSVTLEWAPPLDPGGRSDITYNAVCRRCPWALSHCEACGSGTRFVPQQTSLAQASLLVANLLAHMNYSFWIEAVNGVSNLSPEPRSAAVVNITTNQAAPSQVVVIRQERAGQTSVSLLWQEPEQPNGIILEYEIKYYEKDKEMQSYSTLKAVTTRATVSGLKPGTRYVFQVRARTSAGCGRFSQAMEVETGKPRPRYDTRTIVWICLTLITGLVVLLLLLICKKRHCGYSKAFQDSDEEKMHYQNGQAPPPVFLPLNHPPGKFPETQFSAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLSEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNQDVISSVEEGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFAHVVSVLDALVHSPESLRATATVSRCPPPAFARSCFDLRAGGSGNGDLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLRMNAQDVRALGITLMGHQKKILGSIQTMRAQLSSTQGPRRHL
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth. {ECO:0000269|PubMed:10498895, ECO:0000269|PubMed:11416136, ECO:0000269|PubMed:12681484, ECO:0000269|PubMed:15782114, ECO:0000269|PubMed:17875921, ECO:0000269|PubMed:9214628}.
uniprot
proteins
mass_dalton
110705
uniprot
proteins
mutagenesis
MUTAGEN 615; /note="Y->F: Reduced phosphorylation and reduced association with FYN."; /evidence="ECO:0000269|PubMed:10498895, ECO:0000269|PubMed:11416136"; MUTAGEN 666; /note="K->M,R: Kinase-dead. Loss of autophosphorylation but has no effect on regulation of cell adhesion."; /evidence="ECO:0000269|PubMed:11416136"; MUTAGEN 792; /note="Y->F: Reduced phosphorylation."; /evidence="ECO:0000269|PubMed:11416136"; MUTAGEN 838; /note="Y->F: Reduced tyrosine kinase activity."; /evidence="ECO:0000269|PubMed:10498895
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation is stimulated upon binding of its ligands including EFNA2, EFNA3 and EFNA5. Autophosphorylation on Tyr-615 is critical for association with FYN. Autophosphorylation on Tyr-838 modulates tyrosine kinase activity. {ECO:0000269|PubMed:10498895, ECO:0000269|PubMed:9053851}.; PTM: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation. {ECO:0000269|PubMed:20100865}.
uniprot
proteins
protein_family
Ephrin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10498895
uniprot
proteins
pubmed
11416136
uniprot
proteins
pubmed
12681484
uniprot
proteins
pubmed
15782114
uniprot
proteins
pubmed
17875921
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20100865
uniprot
proteins
pubmed
20496116
uniprot
proteins
pubmed
9053851
uniprot
proteins
pubmed
9214628
uniprot
proteins
sequence_length
1004
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9053851}; Single-pass type I membrane protein {ECO:0000255}. Cell projection {ECO:0000269|PubMed:17875921}. Early endosome membrane {ECO:0000269|PubMed:20496116}. Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes (PubMed:20496116). {ECO:0000269|PubMed:20496116}.
uniprot
proteins
transmembrane_region
TRANSMEM 542..562; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins