Ackr3
entrez
12778
canonical
uniprot
P56485
canonical
ensembl
ENSMUSG00000044337
resolver
ensp
ENSMUSP00000069114
resolver
ensp
ENSMUSP00000193404
resolver
ensp
ENSMUSP00000193412
resolver
enst
ENSMUST00000065587
resolver
genesymbol
Ackr3
resolver
genesymbol_syn
Cmkor1
resolver
genesymbol_syn
Cxcr7
resolver
genesymbol_syn
Rdc1
resolver
uniprot
Q91WI0
resolver
uniprot_entry
ACKR3_MOUSE
resolver
uniprot_sec
Q91WI0
resolver
amino_acid_sequence
MDVHLFDYAEPGNYSDINWPCNSSDCIVVDTVQCPTMPNKNVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVITIPVWVVSLVQHNQWPMGELTCKITHLIFSINLFGSIFFLACMSVDRYLSITYFTGTSSYKKKMVRRVVCILVWLLAFFVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVILGFAVPFTIIAIFYFLLARAMSASGDQEKHSSRKIIFSYVVVFLVCWLPYHFVVLLDIFSILHYIPFTCQLENVLFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQNTK
uniprot
proteins
function
FUNCTION: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels (PubMed:31211835). Acts as a receptor for SHLP2, mediating its effects on activation of proopiomelanocortin neurons in the arcuate nucleus of the hypothalamus which leads to suppression of food intake and increased energy expenditure (By similarity). {ECO:0000250|UniProtKB:P25106, ECO:0000269|PubMed:17804806, ECO:0000269|PubMed:18442043, ECO:0000269|PubMed:20161793, ECO:0000269|PubMed:21220100, ECO:0000269|PubMed:21246655, ECO:0000269|PubMed:31211835}.
uniprot
proteins
mass_dalton
41636
uniprot
proteins
post_translational_modification
PTM: The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated. {ECO:0000250|UniProtKB:P25106}.; PTM: Ubiquitinated at the Lys residues in its C-terminal cytoplasmic tail and is essential for correct trafficking from and to the cell membrane. Deubiquitinated by CXCL12-stimulation in a reversible manner. {ECO:0000250|UniProtKB:P25106}.
uniprot
proteins
protein_family
Atypical chemokine receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16940167
uniprot
proteins
pubmed
17804806
uniprot
proteins
pubmed
18442043
uniprot
proteins
pubmed
20161793
uniprot
proteins
pubmed
20681075
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21220100
uniprot
proteins
pubmed
21246655
uniprot
proteins
pubmed
31211835
uniprot
proteins
pubmed
9510554
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21220100}; Multi-pass membrane protein {ECO:0000269|PubMed:21220100}. Early endosome {ECO:0000250|UniProtKB:P25106}. Recycling endosome {ECO:0000269|PubMed:21220100}. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits in a beta-arrestin-dependent manner. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane. {ECO:0000250|UniProtKB:P25106}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..68; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 119..139; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 253..273; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 297..319; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins