Scarb1
entrez
20778
canonical
uniprot
Q61009
canonical
ensembl
ENSMUSG00000037936
resolver
ensp
ENSMUSP00000083242
resolver
ensp
ENSMUSP00000107021
resolver
ensp
ENSMUSP00000280625
resolver
ensp
ENSMUSP00000280628
resolver
ensp
ENSMUSP00000280630
resolver
ensp
ENSMUSP00000280635
resolver
ensp
ENSMUSP00000280638
resolver
genesymbol
Scarb1
resolver
genesymbol_syn
Srb1
resolver
uniprot
D3Z2V4
resolver
uniprot
Q3TZ42
resolver
uniprot
Q4FK30
resolver
uniprot
Q9CWJ7
resolver
uniprot_entry
SCRB1_MOUSE
resolver
uniprot_sec
D3Z2V4
resolver
uniprot_sec
Q3TZ42
resolver
uniprot_sec
Q4FK30
resolver
uniprot_sec
Q9CWJ7
resolver
amino_acid_sequence
MGGSSRARWVALGLGALGLLFAALGVVMILMVPSLIKQQVLKNVRIDPSSLSFGMWKEIPVPFYLSVYFFEVVNPNEVLNGQKPVVRERGPYVYREFRQKVNITFNDNDTVSFVENRSLHFQPDKSHGSESDYIVLPNILVLGGSILMESKPVSLKLMMTLALVTMGQRAFMNRTVGEILWGYDDPFVHFLNTYLPDMLPIKGKFGLFVGMNNSNSGVFTVFTGVQNFSRIHLVDKWNGLSKIDYWHSEQCNMINGTSGQMWAPFMTPESSLEFFSPEACRSMKLTYNESRVFEGIPTYRFTAPDTLFANGSVYPPNEGFCPCRESGIQNVSTCRFGAPLFLSHPHFYNADPVLSEAVLGLNPNPKEHSLFLDIHPVTGIPMNCSVKMQLSLYIKSVKGIGQTGKIEPVVLPLLWFEQSGAMGGKPLSTFYTQLVLMPQVLHYAQYVLLGLGGLLLLVPIICQLRSQEKCFLFWSGSKKGSQDKEAIQAYSESLMSPAAKGTVLQEAKL
uniprot
proteins
function
FUNCTION: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (By similarity). Both isoform 1 and isoform 2 act as receptors for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:9254074, PubMed:9614139). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (By similarity). {ECO:0000250|UniProtKB:Q8WTV0, ECO:0000269|PubMed:9254074, ECO:0000269|PubMed:9614139}.
uniprot
proteins
mass_dalton
56754
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250}.; PTM: The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.
uniprot
proteins
protein_family
CD36 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21675794
uniprot
proteins
pubmed
8560269
uniprot
proteins
pubmed
9254074
uniprot
proteins
pubmed
9614139
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9254074, ECO:0000269|PubMed:9614139}; Multi-pass membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000269|PubMed:9614139}; Multi-pass membrane protein {ECO:0000250}. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:9614139}. Membrane, caveola {ECO:0000269|PubMed:9614139}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:9614139}. Membrane, caveola {ECO:0000269|PubMed:9614139}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 441..461; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins