MFGE8
entrez
4240
canonical
uniprot
Q08431
canonical
ensembl
ENSG00000140545
resolver
ensp
ENSP00000268150
resolver
ensp
ENSP00000268151
resolver
ensp
ENSP00000444332
resolver
ensp
ENSP00000452734
resolver
ensp
ENSP00000512026
resolver
ensp
ENSP00000512163
resolver
enst
ENST00000558018
resolver
enst
ENST00000695568
resolver
genesymbol
MFGE8
resolver
hgnc
HGNC:7036
resolver
uniprot
A0A8Q3SIZ9
resolver
uniprot
B2R6M7
resolver
uniprot
B3KTQ2
resolver
uniprot
B4E396
resolver
uniprot
F5GZN3
resolver
uniprot
H0YKB5
resolver
uniprot
Q53FU9
resolver
uniprot
Q7Z3D2
resolver
uniprot
Q9BTL9
resolver
uniprot_entry
A0A8Q3SIZ9_HUMAN
resolver
uniprot_entry
B3KTQ2_HUMAN
resolver
uniprot_entry
B4E396_HUMAN
resolver
uniprot_entry
H0YKB5_HUMAN
resolver
uniprot_entry
MFGM_HUMAN
resolver
uniprot_sec
B2R6M7
resolver
uniprot_sec
F5GZN3
resolver
uniprot_sec
Q53FU9
resolver
uniprot_sec
Q7Z3D2
resolver
uniprot_sec
Q9BTL9
resolver
amino_acid_sequence
MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKGYAGNHCETKCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC
uniprot
proteins
function
FUNCTION: Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. {ECO:0000250, ECO:0000269|PubMed:19204935}.; FUNCTION: [Medin]: Main constituent of aortic medial amyloid. {ECO:0000269|PubMed:19204935}.
uniprot
proteins
mass_dalton
43105
uniprot
proteins
post_translational_modification
PTM: Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.
uniprot
proteins
pubmed
10411933
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18780401
uniprot
proteins
pubmed
1909932
uniprot
proteins
pubmed
19204935
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
8639264
uniprot
proteins
pubmed
9260929
uniprot
proteins
pubmed
9535276
uniprot
proteins
sequence_length
387
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:19204935}; Peripheral membrane protein {ECO:0000269|PubMed:19204935}. Secreted {ECO:0000269|PubMed:19204935}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:P79385}; Peripheral membrane protein {ECO:0000250|UniProtKB:P79385}. Note=Located in the acrosomal region of zona-pellucida bound sperm. {ECO:0000250|UniProtKB:P79385}.
uniprot
proteins