Hadh
entrez
15107
canonical
uniprot
Q61425
canonical
ensembl
ENSMUSG00000027984
resolver
ensp
ENSMUSP00000029610
resolver
genesymbol
Hadh
resolver
genesymbol_syn
Hadhsc
resolver
genesymbol_syn
Mschad
resolver
genesymbol_syn
Schad
resolver
uniprot
Q3TF75
resolver
uniprot
Q3THK8
resolver
uniprot
Q3UFI0
resolver
uniprot
Q8K149
resolver
uniprot
Q925U9
resolver
uniprot_entry
HCDH_MOUSE
resolver
uniprot_sec
Q3TF75
resolver
uniprot_sec
Q3THK8
resolver
uniprot_sec
Q3UFI0
resolver
uniprot_sec
Q8K149
resolver
uniprot_sec
Q925U9
resolver
amino_acid_sequence
MAFVTRQFLRSMSSSSSASAAAKKILIKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLKRMAKKKFTENPKAGDEFVEKTLSCLSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANATTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIVNRLLVPYLIEAVRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMEPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKYK
uniprot
proteins
ec_number
1.1.1.35
uniprot
proteins
function
FUNCTION: Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (By similarity). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (PubMed:20670938). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (PubMed:36398584). {ECO:0000250|UniProtKB:P00348, ECO:0000269|PubMed:20670938, ECO:0000269|PubMed:36398584}.; FUNCTION: [Isoform 2]: Inhibits cell proliferation. {ECO:0000269|PubMed:35339755}.
uniprot
proteins
mass_dalton
34464
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
uniprot
proteins
post_translational_modification
PTM: Succinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5. {ECO:0000269|PubMed:23806337}.
uniprot
proteins
protein_family
3-hydroxyacyl-CoA dehydrogenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20670938
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
35339755
uniprot
proteins
pubmed
36398584
uniprot
proteins
pubmed
7642117
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion matrix {ECO:0000269|PubMed:35339755}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:35339755}. Cytoplasm, cytosol {ECO:0000269|PubMed:35339755}. Note=Predominantly nuclear. {ECO:0000269|PubMed:35339755}.
uniprot
proteins