Sirpa
entrez
25528
canonical
uniprot
P97710
canonical
ensembl
ENSRNOG00000004763
resolver
ensembl
ENSRNOG00055006052
resolver
ensembl
ENSRNOG00060015357
resolver
ensembl
ENSRNOG00065014341
resolver
ensp
ENSRNOP00000006408
resolver
ensp
ENSRNOP00000083855
resolver
ensp
ENSRNOP00000092321
resolver
ensp
ENSRNOP00055007571
resolver
ensp
ENSRNOP00060021204
resolver
ensp
ENSRNOP00065018471
resolver
enst
ENSRNOT00000117905
resolver
enst
ENSRNOT00055009812
resolver
enst
ENSRNOT00060026522
resolver
enst
ENSRNOT00065023723
resolver
genesymbol
Sirpa
resolver
genesymbol_syn
Bit
resolver
genesymbol_syn
Mfr
resolver
genesymbol_syn
Ptpns1
resolver
genesymbol_syn
Shps1
resolver
genesymbol_syn
Sirp
resolver
uniprot
A0A8I6A0T2
resolver
uniprot
O08951
resolver
uniprot
O70426
resolver
uniprot
Q499T3
resolver
uniprot
Q9QWI5
resolver
uniprot_entry
A0A8I6A0T2_RAT
resolver
uniprot_entry
Q499T3_RAT
resolver
uniprot_entry
SHPS1_RAT
resolver
uniprot_sec
O08951
resolver
uniprot_sec
O70426
resolver
uniprot_sec
Q9QWI5
resolver
amino_acid_sequence
MEPAGPAPGRLGPLLFCLLLSASCFCAGASGKELKVTQADKSVSVAAGDSATLNCTVSSLTPVGPIKWFKGEGQNRSPIYSFIGGEHFPRITNVSDATKRNNMDFSICISNVTPEDAGTYYCVKFQKGIVEPDTEIKSGGGTTLYVLAKPSSPEVSGPDSRGSPGQTVNFTCKSYGFSPRNITLKWLKDGKELSHLETTISSKSNVSYNISSTVSVKLSPEDIHSRVICEVAHVTLEGRPLNGTANFSNIIRVSPTLKITQQPLTPASQVNLTCQVQKFYPKALQLNWLENGNLSRTDKPEHFTDNRDGTYNYTSLFLVNSSAHREDVVFTCQVEHDSQPAITENHTVRAFAHSSSGGSMETIPDNNAYYNWNVFIGVGVACALLVVLLMAALYLLRIKQKKAKGSTSSTRLHEPEKNAREITQIQDTNDINDITYADLNLPKEKKPAPRVPEPNNHTEYASIETGKLPRPEDTLTYADLDMVHLNRAQPTPKPEPSFSEYASVQVQRK
uniprot
proteins
function
FUNCTION: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (By similarity). Receptor for THBS1 (PubMed:24511121). Interaction with THBS1 stimulates phosphorylation of SIRPA (PubMed:24511121). In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production (PubMed:24511121). {ECO:0000250|UniProtKB:P78324, ECO:0000250|UniProtKB:P97797, ECO:0000269|PubMed:9271230}.
uniprot
proteins
mass_dalton
55691
uniprot
proteins
mutagenesis
MUTAGEN 436; /note="Y->F: Abolishes tyrosine phosphorylation and PTPN11 binding; when associated with F-460; F-477 and F-501."; /evidence="ECO:0000269|PubMed:9535915"; MUTAGEN 460; /note="Y->F: Abolishes tyrosine phosphorylation and PTPN11 binding; when associated with F-436; F-477 and F-501."; /evidence="ECO:0000269|PubMed:9535915"; MUTAGEN 477; /note="Y->F: Strongly reduces insulin-induced tyrosine phosphorylation and PTPN11 binding. Abolishes tyrosine phosphorylation and PTPN11 binding; when associated with F-436; F-460 and F-501."; /evidence="ECO:0000269|PubMed:9535915"; MUTAGEN 501; /note="Y->F: Strongly reduces insulin-induced tyrosine phosphorylation and PTPN11 binding. Abolishes tyrosine phosphorylation and PTPN11 binding; when associated with F-436; F-460 and F-477."; /evidence="ECO:0000269|PubMed:9535915
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:8943344, ECO:0000269|PubMed:9774638}.; PTM: Phosphorylated on tyrosine residues in response to insulin, cell adhesion or epidermal growth factors. Dephosphorylated by PTPN11. {ECO:0000269|PubMed:8943344, ECO:0000269|PubMed:9271230, ECO:0000269|PubMed:9344856, ECO:0000269|PubMed:9535915}.
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
24511121
uniprot
proteins
pubmed
8943344
uniprot
proteins
pubmed
9271230
uniprot
proteins
pubmed
9344856
uniprot
proteins
pubmed
9535915
uniprot
proteins
pubmed
9712053
uniprot
proteins
pubmed
9774638
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 374..394; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins