Pde10a
entrez
23984
canonical
uniprot
Q8CA95
canonical
ensembl
ENSMUSG00000023868
resolver
ensp
ENSMUSP00000086485
resolver
ensp
ENSMUSP00000111385
resolver
ensp
ENSMUSP00000111389
resolver
enst
ENSMUST00000115724
resolver
genesymbol
Pde10a
resolver
uniprot
A0A384DV92
resolver
uniprot
Q3TLU6
resolver
uniprot
Q3TRG6
resolver
uniprot
Q69C21
resolver
uniprot
Q9WVI1
resolver
uniprot_entry
A0A384DV92_MOUSE
resolver
uniprot_entry
PDE10_MOUSE
resolver
uniprot_sec
Q3TLU6
resolver
uniprot_sec
Q3TRG6
resolver
uniprot_sec
Q69C21
resolver
uniprot_sec
Q9WVI1
resolver
amino_acid_sequence
MSNDSTEGTVGSCNATGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKTNKAKDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYFLGECNNSLCVFIPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPIFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMRFNLPARICRDIELFHFDIGPFENMWPGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPGPAPSKSTPEKLNVKVED
uniprot
proteins
ec_number
3.1.4.17
uniprot
proteins
function
FUNCTION: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (PubMed:10359840). Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10359840). May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:10359840, PubMed:14751289, PubMed:27058446). {ECO:0000269|PubMed:10359840, ECO:0000269|PubMed:14751289, ECO:0000269|PubMed:27058446}.
uniprot
proteins
mass_dalton
89408
uniprot
proteins
mutagenesis
MUTAGEN 101; /note="Y->C: Decreased protein abundance; decreased 3',5'-cyclic-nucleotide phosphodiesterase activity."; /evidence="ECO:0000269|PubMed:27058446
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. {ECO:0000269|PubMed:10359840}.; PATHWAY: Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1. {ECO:0000269|PubMed:10359840}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
pubmed
10359840
uniprot
proteins
pubmed
14751289
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27058446
uniprot
proteins
sequence_length
790
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Y233}.
uniprot
proteins