Kctd6
entrez
71393
canonical
uniprot
Q8BNL5
canonical
ensembl
ENSMUSG00000021752
resolver
ensp
ENSMUSP00000022272
resolver
ensp
ENSMUSP00000129059
resolver
ensp
ENSMUSP00000167071
resolver
ensp
ENSMUSP00000167074
resolver
ensp
ENSMUSP00000167083
resolver
ensp
ENSMUSP00000167084
resolver
enst
ENSMUST00000022272
resolver
enst
ENSMUST00000170111
resolver
genesymbol
Kctd6
resolver
uniprot
A2RS47
resolver
uniprot
Q3TXX1
resolver
uniprot_entry
A2RS47_MOUSE
resolver
uniprot_entry
KCTD6_MOUSE
resolver
uniprot_sec
Q3TXX1
resolver
amino_acid_sequence
MDNGDWGYMMSDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPRPLYPMDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD
uniprot
proteins
function
FUNCTION: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu7 probably implicating CUL3-dependent proteasomal degradation. {ECO:0000250|UniProtKB:Q8NC69}.
uniprot
proteins
mass_dalton
27624
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21472142
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q8NC69}. Note=Colocalizes with ANK1 isoform Mu7 at the M line in differentiated skeletal muscle cells and heart. {ECO:0000250|UniProtKB:Q8NC69}.
uniprot
proteins