DRAM2
entrez
128338
canonical
uniprot
Q6UX65
canonical
ensembl
ENSG00000156171
resolver
ensp
ENSP00000286692
resolver
ensp
ENSP00000437718
resolver
ensp
ENSP00000503400
resolver
ensp
ENSP00000545125
resolver
ensp
ENSP00000545126
resolver
ensp
ENSP00000545128
resolver
ensp
ENSP00000545129
resolver
ensp
ENSP00000545130
resolver
ensp
ENSP00000545131
resolver
ensp
ENSP00000545133
resolver
ensp
ENSP00000545136
resolver
ensp
ENSP00000545137
resolver
ensp
ENSP00000545138
resolver
ensp
ENSP00000545139
resolver
ensp
ENSP00000545141
resolver
ensp
ENSP00000545144
resolver
ensp
ENSP00000545147
resolver
ensp
ENSP00000545148
resolver
ensp
ENSP00000545150
resolver
ensp
ENSP00000545152
resolver
ensp
ENSP00000545154
resolver
ensp
ENSP00000545155
resolver
ensp
ENSP00000545158
resolver
ensp
ENSP00000603827
resolver
ensp
ENSP00000603829
resolver
ensp
ENSP00000603830
resolver
ensp
ENSP00000603832
resolver
ensp
ENSP00000603835
resolver
ensp
ENSP00000603837
resolver
ensp
ENSP00000603839
resolver
ensp
ENSP00000603840
resolver
ensp
ENSP00000614844
resolver
ensp
ENSP00000614845
resolver
enst
ENST00000286692
resolver
enst
ENST00000484310
resolver
enst
ENST00000539140
resolver
enst
ENST00000875066
resolver
enst
ENST00000875067
resolver
enst
ENST00000875069
resolver
enst
ENST00000875070
resolver
enst
ENST00000875071
resolver
enst
ENST00000875072
resolver
enst
ENST00000875074
resolver
enst
ENST00000875077
resolver
enst
ENST00000875078
resolver
enst
ENST00000875079
resolver
enst
ENST00000875080
resolver
enst
ENST00000875082
resolver
enst
ENST00000875085
resolver
enst
ENST00000875088
resolver
enst
ENST00000875089
resolver
enst
ENST00000875091
resolver
enst
ENST00000875093
resolver
enst
ENST00000875095
resolver
enst
ENST00000875096
resolver
enst
ENST00000875099
resolver
enst
ENST00000933768
resolver
enst
ENST00000933770
resolver
enst
ENST00000933771
resolver
enst
ENST00000933773
resolver
enst
ENST00000933776
resolver
enst
ENST00000933778
resolver
enst
ENST00000933780
resolver
enst
ENST00000933781
resolver
enst
ENST00000944785
resolver
enst
ENST00000944786
resolver
genesymbol
DRAM2
resolver
genesymbol_syn
TMEM77
resolver
hgnc
HGNC:28769
resolver
uniprot
B3SUG9
resolver
uniprot
Q4VWF6
resolver
uniprot
Q86VD3
resolver
uniprot
Q8NBQ4
resolver
uniprot_entry
DRAM2_HUMAN
resolver
uniprot_sec
B3SUG9
resolver
uniprot_sec
Q4VWF6
resolver
uniprot_sec
Q86VD3
resolver
uniprot_sec
Q8NBQ4
resolver
amino_acid_sequence
MWWFQQGLSFLPSALVIWTSAAFIFSYITAVTLHHIDPALPYISDTGTVAPEKCLFGAMLNIAAVLCIATIYVRYKQVHALSPEENVIIKLNKAGLVLGILSCLGLSIVANFQKTTLFAAHVSGAVLTFGMGSLYMFVQTILSYQMQPKIHGKQVFWIRLLLVIWCGVSALSMLTCSSVLHSGNFGTDLEQKLHWNPEDKGYVLHMITTAAEWSMSFSFFGFFLTYIRDFQKISLRVEANLHGLTLYDTAPCPINNERTRLLSRDI
uniprot
proteins
disease_involvement
DISEASE: Cone-rod dystrophy 21 (CORD21) [MIM:616502]: A form of cone-rod dystrophy, an inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors. {ECO:0000269|PubMed:25983245}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1. {ECO:0000269|PubMed:19895784, ECO:0000269|PubMed:25983245}.
uniprot
proteins
mass_dalton
29766
uniprot
proteins
protein_family
DRAM/TMEM150 family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19556885
uniprot
proteins
pubmed
19895784
uniprot
proteins
pubmed
25983245
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:19556885, ECO:0000269|PubMed:19895784}; Multi-pass membrane protein {ECO:0000269|PubMed:19556885, ECO:0000269|PubMed:19895784}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9CR48}. Apical cell membrane {ECO:0000250|UniProtKB:Q9CR48}. Note=Localized to photoreceptor inner segments and to the apical surface of retinal pigment epithelial cells. {ECO:0000250|UniProtKB:Q9CR48}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins