A1cf
entrez
170912
canonical
uniprot
Q923K9
canonical
ensembl
ENSRNOG00000033195
resolver
ensp
ENSRNOP00000062802
resolver
enst
ENSRNOT00000067643
resolver
genesymbol
A1cf
resolver
genesymbol_syn
Acf
resolver
genesymbol_syn
Asp
resolver
uniprot
F1LNL0
resolver
uniprot
Q8CH55
resolver
uniprot
Q8CH56
resolver
uniprot
Q8CH57
resolver
uniprot
Q8CH58
resolver
uniprot
Q924K3
resolver
uniprot_entry
A1CF_RAT
resolver
uniprot_entry
F1LNL0_RAT
resolver
uniprot_sec
Q8CH55
resolver
uniprot_sec
Q8CH56
resolver
uniprot_sec
Q8CH57
resolver
uniprot_sec
Q8CH58
resolver
uniprot_sec
Q924K3
resolver
amino_acid_sequence
MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDTTPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKQEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRRLLPGRIQLWGHPIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNSIKPGAVERVKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRNTMLQEYTYPLSHVYDPTTTYLGAPVFYTPQAYAAIPSLHFPATKGHLSNRALIRTPSVREIYMNVPVGAAGVRGLGGRGYLAYTGLGRGYQVKGDKRQDKLYDLLPGMELTPMNTISLKPQGVKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKVTIPALASQNPAIHPFTPPKLSAYVDEAKRYAAEHTLQTLGIPTEGGDAGTTAPTATSATVFPGYAVPSATAPVSTAQLKQAVTLGQDLAAYTTYEVYPTFAVTTRGDGYGTF
uniprot
proteins
function
FUNCTION: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also seems to protect the edited APOB mRNA from nonsense-mediated decay (By similarity). {ECO:0000250|UniProtKB:Q9NQ94, ECO:0000269|PubMed:10781591}.
uniprot
proteins
mass_dalton
65620
uniprot
proteins
pubmed
10781591
uniprot
proteins
pubmed
11870221
uniprot
proteins
pubmed
14570923
uniprot
proteins
sequence_length
594
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11870221}. Endoplasmic reticulum {ECO:0000269|PubMed:11870221}. Cytoplasm {ECO:0000269|PubMed:11870221}. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum. Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1.
uniprot
proteins