DAPP1
entrez
27071
canonical
uniprot
Q9UN19
canonical
ensembl
ENSG00000070190
resolver
ensp
ENSP00000296414
resolver
ensp
ENSP00000423602
resolver
ensp
ENSP00000650265
resolver
ensp
ENSP00000799144
resolver
enst
ENST00000296414
resolver
genesymbol
DAPP1
resolver
genesymbol_syn
BAM32
resolver
hgnc
HGNC:16500
resolver
uniprot
J3KNB3
resolver
uniprot
Q8TCK5
resolver
uniprot
Q9UHF2
resolver
uniprot_entry
DAPP1_HUMAN
resolver
uniprot_entry
J3KNB3_HUMAN
resolver
uniprot_sec
Q8TCK5
resolver
uniprot_sec
Q9UHF2
resolver
amino_acid_sequence
MGRAELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVNCFCLVFPFRTFYLCAKTGVEADEWIKILRWKLSQIRKQLNQGEGTIRSRSFIFK
uniprot
proteins
function
FUNCTION: May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. {ECO:0000269|PubMed:10770799}.
uniprot
proteins
mass_dalton
32194
uniprot
proteins
mutagenesis
MUTAGEN 61; /note="R->K: No change in BCR-induced NFAT activation."; /evidence="ECO:0000269|PubMed:10770799"; MUTAGEN 173; /note="K->L: No interaction with 3-phosphoinositides."; /evidence="ECO:0000269|PubMed:10432293"; MUTAGEN 184; /note="R->C: No membrane association."; /evidence="ECO:0000269|PubMed:10770799"; MUTAGEN 197; /note="K->E: No membrane association."; /evidence="ECO:0000269|PubMed:10770799"; MUTAGEN 250; /note="W->L: No interaction with 3-phosphoinositides."; /evidence="ECO:0000269|PubMed:10432293
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues. {ECO:0000269|PubMed:10770799}.
uniprot
proteins
pubmed
10432293
uniprot
proteins
pubmed
10770799
uniprot
proteins
pubmed
10983984
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
sequence_length
280
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10770799}. Membrane {ECO:0000269|PubMed:10770799}; Peripheral membrane protein {ECO:0000269|PubMed:10770799}. Note=Membrane-associated after cell stimulation leading to its translocation.
uniprot
proteins