GHRL
entrez
51738
canonical
uniprot
Q9UBU3
canonical
ensembl
ENSG00000157017
resolver
ensp
ENSP00000287656
resolver
ensp
ENSP00000335074
resolver
ensp
ENSP00000388145
resolver
ensp
ENSP00000391406
resolver
ensp
ENSP00000399922
resolver
ensp
ENSP00000403725
resolver
ensp
ENSP00000414819
resolver
ensp
ENSP00000416768
resolver
genesymbol
GHRL
resolver
genesymbol_syn
MTLRP
resolver
hgnc
HGNC:18129
resolver
uniprot
A8CF34
resolver
uniprot
A8CF38
resolver
uniprot
A8CF42
resolver
uniprot
A8DN29
resolver
uniprot
A8DN30
resolver
uniprot
Q86YP8
resolver
uniprot
Q8TAT9
resolver
uniprot
Q9H3R3
resolver
uniprot_entry
GHRL_HUMAN
resolver
uniprot_sec
A8CF34
resolver
uniprot_sec
A8CF38
resolver
uniprot_sec
A8CF42
resolver
uniprot_sec
A8DN29
resolver
uniprot_sec
A8DN30
resolver
uniprot_sec
Q86YP8
resolver
uniprot_sec
Q8TAT9
resolver
uniprot_sec
Q9H3R3
resolver
amino_acid_sequence
MPSPGTVCSLLLLGMLWLDLAMAGSSFLSPEHQRVQQRKESKKPPAKLQPRALAGWLRPEDGGQAEGAEDELEVRFNAPFDVGIKLSGVQYQQHSQALGKFLQDILWEEAKEAPADK
uniprot
proteins
function
FUNCTION: Precursor of the appetite-regulating peptide ghrelin, including ghrelin-27 and ghrelin-28. {ECO:0000269|PubMed:11306336, ECO:0000269|PubMed:35027551}.; FUNCTION: [Ghrelin-27]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470, PubMed:35027551). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion (PubMed:11739476). Involved in growth regulation (PubMed:10604470). {ECO:0000269|PubMed:10604470, ECO:0000269|PubMed:11739476, ECO:0000269|PubMed:35027551}.; FUNCTION: [Ghrelin-28]: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470, PubMed:35027551). Octanoylated ghrelin-28 is the most commonly found ghrelin and octanoylation is essential for the activation of the growth hormone secretagogue receptor type 1 (GHSR) (PubMed:11306336, PubMed:35027551). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion (PubMed:11739476). Involved in growth regulation (PubMed:10604470). {ECO:0000269|PubMed:10604470, ECO:0000269|PubMed:11306336, ECO:0000269|PubMed:11739476, ECO:0000269|PubMed:35027551}.; FUNCTION: [Obestatin]: May have an appetite-reducing effect resulting in decreased food intake (By similarity). May reduce gastric emptying activity and jejunal motility (By similarity). {ECO:0000250|UniProtKB:Q9QYH7}.
uniprot
proteins
mass_dalton
12911
uniprot
proteins
post_translational_modification
PTM: O-octanoylated by GOAT/MBOAT4 (PubMed:18443287). O-octanoylation or O-decanoylation is essential for ghrelin activity (PubMed:10604470, PubMed:35027551). The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26 (PubMed:10604470). A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid (PubMed:10604470). Also O-acetylated and O-butyrylated on Ser-26 to minor levels (PubMed:18443287). {ECO:0000269|PubMed:10604470, ECO:0000269|PubMed:18443287, ECO:0000269|PubMed:35027551}.; PTM: Amidation of Leu-98 is essential for obestatin activity. {ECO:0000250|UniProtKB:Q9QYH7}.
uniprot
proteins
protein_family
Motilin family
uniprot
proteins
pubmed
10604470
uniprot
proteins
pubmed
10930375
uniprot
proteins
pubmed
11306336
uniprot
proteins
pubmed
11739476
uniprot
proteins
pubmed
12414809
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17727735
uniprot
proteins
pubmed
18443287
uniprot
proteins
pubmed
35027551
uniprot
proteins
sequence_length
117
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9EQX0}.
uniprot
proteins