STK33
entrez
65975
canonical
uniprot
Q9BYT3
canonical
ensembl
ENSG00000130413
resolver
ensp
ENSP00000320754
resolver
ensp
ENSP00000351743
resolver
ensp
ENSP00000379905
resolver
ensp
ENSP00000416750
resolver
ensp
ENSP00000436418
resolver
ensp
ENSP00000509322
resolver
ensp
ENSP00000580695
resolver
ensp
ENSP00000580696
resolver
ensp
ENSP00000580697
resolver
ensp
ENSP00000580702
resolver
ensp
ENSP00000580703
resolver
ensp
ENSP00000580705
resolver
ensp
ENSP00000580706
resolver
ensp
ENSP00000580707
resolver
ensp
ENSP00000580708
resolver
ensp
ENSP00000603879
resolver
ensp
ENSP00000603882
resolver
ensp
ENSP00000637174
resolver
ensp
ENSP00000637183
resolver
ensp
ENSP00000637187
resolver
ensp
ENSP00000637189
resolver
ensp
ENSP00000637190
resolver
enst
ENST00000358872
resolver
enst
ENST00000534493
resolver
genesymbol
STK33
resolver
hgnc
HGNC:14568
resolver
uniprot
B3KS39
resolver
uniprot
B4DDH2
resolver
uniprot
F6UB56
resolver
uniprot
F8WAK5
resolver
uniprot
Q658S6
resolver
uniprot
Q8NEF5
resolver
uniprot_entry
B3KS39_HUMAN
resolver
uniprot_entry
B4DDH2_HUMAN
resolver
uniprot_entry
F6UB56_HUMAN
resolver
uniprot_entry
F8WAK5_HUMAN
resolver
uniprot_entry
STK33_HUMAN
resolver
uniprot_sec
Q658S6
resolver
uniprot_sec
Q8NEF5
resolver
activity_regulation
ACTIVITY REGULATION: Specifically inhibited by CDD-2807 ((3-([1,1'-Biphenyl]-2-ylethynyl)-1H-indazol-5-yl)(2,6-diazaspiro[3.5]nonan-2-yl)methanone). {ECO:0000269|PubMed:38781365}.
uniprot
proteins
amino_acid_sequence
MADSGLDKKSTKCPDCSSASQKDVLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISLERKKEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENGAAIEEIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNKPSTEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSSFTSSKLLPAEIKGEMEKTPVTPSQGTATKYPAKSGALSRTKKKL
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 93 (SPGF93) [MIM:620849]: An autosomal recessive, male infertility disorder characterized by asthenozoospermia and multiple morphologic abnormalities of the sperm flagella. {ECO:0000269|PubMed:34155512, ECO:0000269|PubMed:37146716}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q924X7, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}.
uniprot
proteins
mass_dalton
57831
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000250|UniProtKB:Q924X7}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11738831
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16176263
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19490892
uniprot
proteins
pubmed
21742770
uniprot
proteins
pubmed
34155512
uniprot
proteins
pubmed
37146716
uniprot
proteins
pubmed
38781365
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q924X7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q924X7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q924X7}. Note=Colocalizes with the caudal end of the manchette, a transient structure that guides tail elongation in elongating spermatids. {ECO:0000250|UniProtKB:Q924X7}.
uniprot
proteins