Rcor1
entrez
217864
canonical
uniprot
Q8CFE3
canonical
ensembl
ENSMUSG00000037896
resolver
ensp
ENSMUSP00000082034
resolver
ensp
ENSMUSP00000112089
resolver
enst
ENSMUST00000084968
resolver
enst
ENSMUST00000116388
resolver
genesymbol
Rcor1
resolver
genesymbol_syn
D12Wsu95e
resolver
genesymbol_syn
Kiaa0071
resolver
uniprot
A0A140T8R7
resolver
uniprot
K3W4P9
resolver
uniprot
Q3V092
resolver
uniprot
Q8BK28
resolver
uniprot
Q8CHI2
resolver
uniprot_entry
A0A140T8R7_MOUSE
resolver
uniprot_entry
RCOR1_MOUSE
resolver
uniprot_sec
K3W4P9
resolver
uniprot_sec
Q3V092
resolver
uniprot_sec
Q8BK28
resolver
uniprot_sec
Q8CHI2
resolver
amino_acid_sequence
MPAMVEKGPEVSGKRRGRNTAASAASAAASAASAAASAAASAGTASASAAAAASAAAAPNNGQNKSLAAAAPNGNSGSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAAVPDFDPAKLARRSQERDNLGMLVWSPNQSLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEETNGSNPVDIEIDPNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSIKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKDETNGPANQKPVKSPESSIKIPEEEDEAASVLDVRYASAS
uniprot
proteins
function
FUNCTION: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:15907476, ECO:0000269|PubMed:17707228, ECO:0000269|PubMed:20346398}.
uniprot
proteins
mass_dalton
52715
uniprot
proteins
protein_family
CoREST family
uniprot
proteins
pubmed
10734093
uniprot
proteins
pubmed
12465718
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15907476
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17707228
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20346398
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24227653
uniprot
proteins
pubmed
30442713
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624}.
uniprot
proteins