APOO
entrez
79135
canonical
uniprot
Q9BUR5
canonical
ensembl
ENSG00000184831
resolver
ensp
ENSP00000368528
resolver
ensp
ENSP00000569563
resolver
ensp
ENSP00000569566
resolver
ensp
ENSP00000762946
resolver
genesymbol
APOO
resolver
genesymbol_syn
FAM121B
resolver
genesymbol_syn
MIC23
resolver
genesymbol_syn
MIC26
resolver
hgnc
HGNC:28727
resolver
uniprot
B2R4K9
resolver
uniprot
Q9H3J9
resolver
uniprot_entry
MIC26_HUMAN
resolver
uniprot_sec
B2R4K9
resolver
uniprot_sec
Q9H3J9
resolver
amino_acid_sequence
MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAPPGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK
uniprot
proteins
function
FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892). {ECO:0000269|PubMed:16956892, ECO:0000269|PubMed:24743151, ECO:0000269|PubMed:25764979}.
uniprot
proteins
mass_dalton
22285
uniprot
proteins
post_translational_modification
PTM: O-glycosylation; glycosaminoglycan of chondroitin-sulfate type. {ECO:0000269|PubMed:16956892, ECO:0000269|PubMed:25764979}.
uniprot
proteins
protein_family
Apolipoprotein O/MICOS complex subunit Mic27 family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16956892
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24743151
uniprot
proteins
pubmed
25764979
uniprot
proteins
pubmed
25781180
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
25997101
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:25764979}; Single-pass membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:16956892, ECO:0000269|PubMed:25764979}. Mitochondrion {ECO:0000269|PubMed:25781180}. Golgi apparatus membrane {ECO:0000269|PubMed:25764979}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:25764979}. Note=Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form. {ECO:0000269|PubMed:25764979}.
uniprot
proteins
transmembrane_region
TRANSMEM 108..128; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins