Chst4
entrez
26887
canonical
uniprot
Q9R1I1
canonical
ensembl
ENSMUSG00000035930
resolver
ensp
ENSMUSP00000104845
resolver
ensp
ENSMUSP00000194163
resolver
ensp
ENSMUSP00000194164
resolver
enst
ENSMUST00000109222
resolver
genesymbol
Chst4
resolver
genesymbol_syn
Gst3
resolver
uniprot
A0A0R4J1C9
resolver
uniprot
Q9WUE5
resolver
uniprot_entry
A0A0R4J1C9_MOUSE
resolver
uniprot_entry
CHST4_MOUSE
resolver
uniprot_sec
Q9WUE5
resolver
amino_acid_sequence
MMLLKKGRLLMFLGSQVIVVALFIHMSVHRHLSQREESRRPVHVLVLSSWRSGSSFVGQLFGQHPDVFYLMEPAWHVWMTFTSSTAWKLHMAVRDLLRSVFLCDMSVFDAYMNPGPRKQSSLFQWEQSRALCSAPVCDFFPAHEISSPKHCKLLCGQQPFDMVEKACRSHGFVVLKEVRFLSLQALYPLLTDPSLNLHVVHLVRDPRAVFRSREHTTIELVVDSHIVLGQHLETIKEEDQPYYAMKIICKSQVDIVKAIQTLPEALQQRYLFLRYEDLVRAPLAQTTRLYKFVGLDFLPHLQTWVHNVTRGKGMGQHAFHTNARNALNVSQAWRWSLPYEKVSQLQDACGEAMDLLGYLQVRSQQEQGNLSLDLLSSSHILGQVFREG
uniprot
proteins
ec_number
2.8.2.-
uniprot
proteins
function
FUNCTION: Sulfotransferase involved in SELL/L-selectin ligand biosynthesis pathway. Catalyzes the transfer of the sulfate group from 3'-phospho-5'-adenylyl sulfate (PAPS) onto the hydroxyl group at C-6 position of the non-reducing N-acetylglucosamine (GlcNAc) residue within O-linked mucin-type glycans (PubMed:10435581, PubMed:14597732, PubMed:15111310, PubMed:15319280, PubMed:16227985, PubMed:16227986). Contributes to generate sialyl 6-sulfo Lewis X determinant (also known as MECA-79 epitope) for SELL recognition, a prerequisite for continuous lymphocyte homing into peripheral lymph nodes and antigen immune surveillance. Transfers the sulfate group primarily on core 2 GlcNAcbeta1-6(Galbeta1-3)GalNAcalphaSer/Thr and extended core 1 GlcNAcbeta1-3Galbeta1-3GalNAcalphaSer/Thr based O-linked glycans on CD34 and GLYCAM1 peripheral node addressins (PNAds) expressed on the lumenal side of high endothelial venules (HEVs) (PubMed:10435581, PubMed:14593101, PubMed:15111310, PubMed:15319280, PubMed:16227985, PubMed:16227986). The recognition of PNAds by SELL initiates a multistep process comprising tethering and rolling of blood lymphocytes on HEVs against the blood flow, followed by chemokine signaling, integrin-mediated lymphocyte adhesion onto endothelial cells and lymphocyte transendothelial migration. Modulates rolling velocity and differential T and B lymphocyte recruitment into peripheral lymph nodes, with a major role in B lymphocyte homing (PubMed:10435581, PubMed:14597732, PubMed:15319280, PubMed:16227985, PubMed:16227986). Might be redundant in sulfation of MADCAM1 and lymphocyte trafficking to mesenteric lymph nodes (PubMed:10435581, PubMed:11520459, PubMed:16227986). Can also sulfonate core 3 GlcNAcbeta1-3GalNAc-R based glycans as well as GlcNAcbeta1-3Galbeta1-Glc, GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharides, which might be ectopically expressed during tumorigenesis (By similarity). {ECO:0000250|UniProtKB:Q8NCG5, ECO:0000269|PubMed:10435581, ECO:0000269|PubMed:11520459, ECO:0000269|PubMed:14593101, ECO:0000269|PubMed:14597732, ECO:0000269|PubMed:15111310, ECO:0000269|PubMed:15319280, ECO:0000269|PubMed:16227985, ECO:0000269|PubMed:16227986}.
uniprot
proteins
mass_dalton
44636
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; carbohydrate sulfation. {ECO:0000269|PubMed:10435581, ECO:0000269|PubMed:16227985}.
uniprot
proteins
protein_family
Gal/GlcNAc/GalNAc subfamily
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
10330415
uniprot
proteins
pubmed
10435581
uniprot
proteins
pubmed
11520459
uniprot
proteins
pubmed
14593101
uniprot
proteins
pubmed
14597732
uniprot
proteins
pubmed
15111310
uniprot
proteins
pubmed
15319280
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16227985
uniprot
proteins
pubmed
16227986
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15111310}; Single-pass type II membrane protein {ECO:0000269|PubMed:15111310}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins