Tipin
entrez
66131
canonical
uniprot
Q91WA1
canonical
ensembl
ENSMUSG00000032397
resolver
ensp
ENSMUSP00000034964
resolver
ensp
ENSMUSP00000149833
resolver
ensp
ENSMUSP00000257194
resolver
ensp
ENSMUSP00000345274
resolver
ensp
ENSMUSP00000345278
resolver
enst
ENSMUST00000034964
resolver
enst
ENSMUST00000216594
resolver
genesymbol
Tipin
resolver
uniprot
Q9CQM3
resolver
uniprot
Q9D1J4
resolver
uniprot_entry
TIPIN_MOUSE
resolver
uniprot_sec
Q9CQM3
resolver
uniprot_sec
Q9D1J4
resolver
amino_acid_sequence
MLEQEENGLFEIPDYEHVEDETFPPFPPPASPERDPADAEPEEGSGSGVPVPPKRTVKRNLPKLDATRLTSERGLPALRHVFDKTKFKGKGHEAEDLKTLIRHMEHWAHRLFPKLQFEDFIDRVENLGNKKEVQTCLKRIRLDLPIVHEDFVNNNDEVGEANGPDVSATGFDPFLTSSSDSRKFASEPTRSLTEEQQQRIERNKQLALERRQAKLLSNSQSLENDVTVEENSTGEDQEESNGLNIDTADGPHDVPFASTHEEEQCKAEETQLDHTNLD
uniprot
proteins
function
FUNCTION: Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. {ECO:0000269|PubMed:17141802}.
uniprot
proteins
mass_dalton
31498
uniprot
proteins
protein_family
CSM3 family
uniprot
proteins
pubmed
12875843
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17141802
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12875843}. Nucleus {ECO:0000269|PubMed:12875843}.
uniprot
proteins