Cdca8
entrez
52276
canonical
uniprot
Q8BHX3
canonical
ensembl
ENSMUSG00000028873
resolver
ensp
ENSMUSP00000081319
resolver
genesymbol
Cdca8
resolver
uniprot
B1ARX0
resolver
uniprot
B1ARX1
resolver
uniprot
Q6NVD3
resolver
uniprot
Q8BHB1
resolver
uniprot
Q8BHQ5
resolver
uniprot
Q8BHQ9
resolver
uniprot
Q9CRN4
resolver
uniprot
Q9CS02
resolver
uniprot
Q9CTF4
resolver
uniprot_entry
BOREA_MOUSE
resolver
uniprot_sec
B1ARX0
resolver
uniprot_sec
B1ARX1
resolver
uniprot_sec
Q6NVD3
resolver
uniprot_sec
Q8BHB1
resolver
uniprot_sec
Q8BHQ5
resolver
uniprot_sec
Q8BHQ9
resolver
uniprot_sec
Q9CRN4
resolver
uniprot_sec
Q9CS02
resolver
uniprot_sec
Q9CTF4
resolver
amino_acid_sequence
MAPKKRSSRGTRTNTLRSRKLASFLKDFDREVQVRTKQIESDRQTLLKEVENLYNIEILRLPKALQGMKWLDYFALGGNKQALEEAAKADRDITEINNLTAEAIQTPLKSVKKRKVIEVEESIKEEEEEEEEGGGGGGRTKKSHKNLRSAKVKRCLPSKKRTQSIQGRGRSKRLSHDFVTPAMSRLEPSLVKPTPGMTPRFDSRVFKTPGLRTPAAKEQVYNISINGSPLADSKEISLSVPIGGGASLRLLASDLQRIDIAQLNPEALGNIRKLSSRLAQICSSIRTGR
uniprot
proteins
function
FUNCTION: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment (By similarity). {ECO:0000250|UniProtKB:Q53HL2}.
uniprot
proteins
mass_dalton
32214
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by TTK, essentially at Thr-94. Phosphorylation (probably by CDK1) promotes targeting of the CPC to centromeric DNA. {ECO:0000250|UniProtKB:Q53HL2}.; PTM: Sumoylated by UBE2I and RANBP2. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3 (By similarity). {ECO:0000250|UniProtKB:Q53HL2}.; PTM: Citrullinated by PADI4. {ECO:0000269|PubMed:24463520}.
uniprot
proteins
protein_family
Borealin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24463520
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q53HL2}. Cytoplasm {ECO:0000250|UniProtKB:Q53HL2}. Chromosome, centromere {ECO:0000250|UniProtKB:Q53HL2}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q53HL2}. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells. {ECO:0000250|UniProtKB:Q53HL2}.
uniprot
proteins