CINP
entrez
51550
canonical
uniprot
Q9BW66
canonical
ensembl
ENSG00000100865
resolver
ensp
ENSP00000216756
resolver
ensp
ENSP00000442377
resolver
genesymbol
CINP
resolver
hgnc
HGNC:23789
resolver
uniprot
F5H7P3
resolver
uniprot
F5H8A7
resolver
uniprot
Q9NPF9
resolver
uniprot_entry
CINP_HUMAN
resolver
uniprot_sec
F5H7P3
resolver
uniprot_sec
F5H8A7
resolver
uniprot_sec
Q9NPF9
resolver
amino_acid_sequence
MEAKTLGTVTPRKPVLSVSARKIKDNAADWHNLILKWETLNDAGFTTANNIANLKISLLNKDKIELDSSSPASKENEEKVCLEYNEELEKLCEELQATLDGLTKIQVKMEKLSSTTKGICELENYHYGEESKRPPLFHTWPTTHFYEVSHKLLEMYRKELLLKRTVAKELAHTGDPDLTLSYLSMWLHQPYVESDSRLHLESMLLETGHRAL
uniprot
proteins
function
FUNCTION: Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication (PubMed:16082200, PubMed:19889979). Regulates ATR-mediated checkpoint signaling in response to DNA damage (PubMed:16082200, PubMed:19889979). Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). As part of 55LCC complex, also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024). {ECO:0000269|PubMed:16082200, ECO:0000269|PubMed:19889979, ECO:0000269|PubMed:35354024, ECO:0000269|PubMed:38554706}.
uniprot
proteins
mass_dalton
24324
uniprot
proteins
mutagenesis
MUTAGEN 11..14; /note="Missing: No effect on interaction with AFG2A and AFG2B."; /evidence="ECO:0000269|PubMed:38554706"; MUTAGEN 21..24; /note="RKIK->AAIA: No effect on interaction with AFG2A and AFG2B."; /evidence="ECO:0000269|PubMed:38554706"; MUTAGEN 162; /note="L->R: Loss of interaction with AFG2A and AFG2B."; /evidence="ECO:0000269|PubMed:38554706"; MUTAGEN 178; /note="L->R: No effect on interaction with AFG2A and AFG2B."; /evidence="ECO:0000269|PubMed:38554706"; MUTAGEN 181; /note="S->R: Strongly decreases interaction with AFG2A and AFG2B."; /evidence="ECO:0000269|PubMed:38554706"; MUTAGEN 184; /note="S->R: Strongly decreases interaction with AFG2A and AFG2B."; /evidence="ECO:0000269|PubMed:38554706
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDC7 but not by CDK2. {ECO:0000269|PubMed:16082200}.
uniprot
proteins
protein_family
CINP family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16082200
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19889979
uniprot
proteins
pubmed
21131973
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
35354024
uniprot
proteins
pubmed
38554706
uniprot
proteins
sequence_length
212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19889979}. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication. {ECO:0000269|PubMed:19889979}.
uniprot
proteins