Rad23b
entrez
19359
canonical
uniprot
P54728
canonical
ensembl
ENSMUSG00000028426
resolver
ensp
ENSMUSP00000030134
resolver
enst
ENSMUST00000030134
resolver
genesymbol
Rad23b
resolver
genesymbol_syn
Mhr23b
resolver
uniprot
Q3TUA4
resolver
uniprot
Q3UQN3
resolver
uniprot_entry
Q3UQN3_MOUSE
resolver
uniprot_entry
RD23B_MOUSE
resolver
uniprot_sec
Q3TUA4
resolver
amino_acid_sequence
MQVTLKTLQQQTFKIDIDPEETVKALKEKIESEKGKDAFPVAGQKLIYAGKILSDDTALKEYKIDEKNFVVVMVTKPKAVTTAVPATTQPSSTPSPTAVSSSPAVAAAQAPAPTPALPPTSTPASTAPASTTASSEPAPAGATQPEKPAEKPAQTPVLTSPAPADSTPGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLLMGIPGDRESQAVVDPPPQAVSTGTPQSPAVAAAAATTTATTTTTSGGHPLEFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQISQHQEHFIQMLNEPVQEAGSQGGGGGGGGGGGGGGGGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNFDED
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
function
FUNCTION: Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation and transcriptional regulation. Specifically demethylates mono-, di- and trimethylated 'Lys-20' of histone H4 (H4K20me1, H4K20me2, H4K20me3, respectively) into unmethylated forms. Activates the transcription of coding genes by demethylating H4K20me1 and the transcription of repetitive elements by demethylating H4K20me3. Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome (PubMed:12815074, PubMed:15336624, PubMed:16709668). Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex, a nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. Cooperatively with CETN2 appears to stabilize XPC (By similarity). {ECO:0000250|UniProtKB:P54727, ECO:0000269|PubMed:12815074, ECO:0000269|PubMed:15336624, ECO:0000269|PubMed:16709668}.
uniprot
proteins
mass_dalton
43513
uniprot
proteins
protein_family
RAD23 family
uniprot
proteins
pubmed
11562482
uniprot
proteins
pubmed
11809813
uniprot
proteins
pubmed
12815074
uniprot
proteins
pubmed
15336624
uniprot
proteins
pubmed
15358861
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16249333
uniprot
proteins
pubmed
16500903
uniprot
proteins
pubmed
16709668
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8808275
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15336624}. Cytoplasm {ECO:0000269|PubMed:15336624}.
uniprot
proteins