Fcgrt
entrez
29558
canonical
uniprot
P13599
canonical
ensembl
ENSRNOG00000020583
resolver
ensembl
ENSRNOG00055005666
resolver
ensembl
ENSRNOG00060008172
resolver
ensembl
ENSRNOG00065028717
resolver
ensp
ENSRNOP00000027944
resolver
ensp
ENSRNOP00000093469
resolver
ensp
ENSRNOP00055006969
resolver
ensp
ENSRNOP00060010328
resolver
ensp
ENSRNOP00065040724
resolver
enst
ENSRNOT00000027944
resolver
enst
ENSRNOT00000104770
resolver
enst
ENSRNOT00055009126
resolver
enst
ENSRNOT00060013550
resolver
enst
ENSRNOT00065049602
resolver
genesymbol
Fcgrt
resolver
genesymbol_syn
Fcrn
resolver
uniprot
A0A8I6GKP0
resolver
uniprot_entry
A0A8I6GKP0_RAT
resolver
uniprot_entry
FCGRN_RAT
resolver
amino_acid_sequence
MGMSQPGVLLSLLLVLLPQTWGAEPRLPLMYHLAAVSDLSTGLPSFWATGWLGAQQYLTYNNLRQEADPCGAWIWENQVSWYWEKETTDLKSKEQLFLEAIRTLENQINGTFTLQGLLGCELAPDNSSLPTAVFALNGEEFMRFNPRTGNWSGEWPETDIVGNLWMKQPEAARKESEFLLTSCPERLLGHLERGRQNLEWKEPPSMRLKARPGNSGSSVLTCAAFSFYPPELKFRFLRNGLASGSGNCSTGPNGDGSFHAWSLLEVKRGDEHHYQCQVEHEGLAQPLTVDLDSPARSSVPVVGIILGLLLVVVAIAGGVLLWNRMRSGLPAPWLSLSGDDSGDLLPGGNLPPEAEPQGVNAFPATS
uniprot
proteins
function
FUNCTION: Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:18818657, PubMed:7969498). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (PubMed:18818657, PubMed:7298722). Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (By similarity). {ECO:0000250|UniProtKB:P55899, ECO:0000269|PubMed:18818657, ECO:0000269|PubMed:7298722, ECO:0000269|PubMed:7969498}.
uniprot
proteins
mass_dalton
40169
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18818657
uniprot
proteins
pubmed
2534798
uniprot
proteins
pubmed
2911353
uniprot
proteins
pubmed
7298722
uniprot
proteins
pubmed
7969498
uniprot
proteins
pubmed
9493268
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2911353}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:P55899}.
uniprot
proteins
transmembrane_region
TRANSMEM 299..322; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins