Kars1
entrez
85305
canonical
uniprot
Q99MN1
canonical
ensembl
ENSMUSG00000031948
resolver
ensp
ENSMUSP00000034426
resolver
ensp
ENSMUSP00000090808
resolver
ensp
ENSMUSP00000126268
resolver
enst
ENSMUST00000034426
resolver
enst
ENSMUST00000093120
resolver
enst
ENSMUST00000164470
resolver
genesymbol
Kars1
resolver
genesymbol_syn
Kars
resolver
uniprot
F7CG76
resolver
uniprot
Q3TIV6
resolver
uniprot
Q8R2P8
resolver
uniprot_entry
F7CG76_MOUSE
resolver
uniprot_entry
Q3TIV6_MOUSE
resolver
uniprot_entry
Q8R2P8_MOUSE
resolver
uniprot_entry
SYK_MOUSE
resolver
amino_acid_sequence
MATLQESEVKVDGEQKLSKNELKRRLKAEKKLAEKEAKQKELSEKQLNQTASAPNHTADNGVGAEEETLDPNQYYKIRSQAVQQLKVTGEDPYPHKFHVDISLTQFIQEYSHLQPGDHLTDVTLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFVHINNKLRRGDIIGVEGNPGKTKKGELSIIPQEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIVRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMLSGMVKSITGSYKITYHPDGPEGQAYEVDFTPPFRRISMVEELEKALGVKLPETSLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCISPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPVRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRLTMFLTDSNNIKEVLLFPAMKPEDKKETAATTETPESTEASPSV
uniprot
proteins
ec_number
2.7.7.-
uniprot
proteins
ec_number
6.1.1.6
uniprot
proteins
function
FUNCTION: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. {ECO:0000250|UniProtKB:Q15046}.
uniprot
proteins
mass_dalton
67840
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on a serine residue after mast cell stimulation with immunoglobulin E (IgE). {ECO:0000250|UniProtKB:Q5XIM7}.
uniprot
proteins
protein_family
Class-II aminoacyl-tRNA synthetase family
uniprot
proteins
pubmed
11331948
uniprot
proteins
pubmed
12060739
uniprot
proteins
pubmed
14659874
uniprot
proteins
pubmed
14975237
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
595
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q15046}. Cytoplasm {ECO:0000250|UniProtKB:Q15046}. Nucleus {ECO:0000250|UniProtKB:Q15046}. Cell membrane {ECO:0000250|UniProtKB:Q15046}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15046}. Secreted {ECO:0000250|UniProtKB:Q15046}. Note=Secretion is induced by TNF. Cytosolic in quiescent mast cells. Translocates into the nucleus in response to mast cell activation by immunoglobulin E. {ECO:0000250|UniProtKB:Q15046}.
uniprot
proteins