METTL18
entrez
92342
canonical
uniprot
O95568
canonical
ensembl
ENSG00000171806
resolver
ensp
ENSP00000307077
resolver
ensp
ENSP00000307975
resolver
ensp
ENSP00000580310
resolver
ensp
ENSP00000580311
resolver
ensp
ENSP00000580312
resolver
ensp
ENSP00000580313
resolver
ensp
ENSP00000607863
resolver
ensp
ENSP00000607864
resolver
enst
ENST00000303469
resolver
enst
ENST00000310392
resolver
enst
ENST00000910251
resolver
enst
ENST00000910252
resolver
enst
ENST00000910253
resolver
enst
ENST00000910254
resolver
enst
ENST00000937804
resolver
enst
ENST00000937805
resolver
genesymbol
METTL18
resolver
genesymbol_syn
ASTP2
resolver
genesymbol_syn
C1orf156
resolver
hgnc
HGNC:28793
resolver
uniprot
B2R9T5
resolver
uniprot_entry
MET18_HUMAN
resolver
uniprot_sec
B2R9T5
resolver
amino_acid_sequence
MTFQFNFTIEDHLENELTPIRDGALTLDSSKELSVSESQKGEERDRKCSAEQFDLPQDHLWEHKSMENAAPSQDTDSPLSAASSSRNLEPHGKQPSLRAAKEHAMPKDLKKMLENKVIETLPGFQHVKLSVVKTILLKENFPGENIVSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTKAKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDEVTLPNVVANSTLEDEENDVNEPDVKRCRKPKVTQLYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFVEERDVFKTRILKIIDEGLKRFIIEITFKFPG
uniprot
proteins
ec_number
2.1.1.85
uniprot
proteins
function
FUNCTION: Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation (PubMed:23349634, PubMed:33693809, PubMed:35674491). Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins (PubMed:35674491). {ECO:0000269|PubMed:23349634, ECO:0000269|PubMed:33693809, ECO:0000269|PubMed:35674491}.
uniprot
proteins
mass_dalton
42148
uniprot
proteins
mutagenesis
MUTAGEN 154; /note="H->A: No effect on automethylation. Loss of protein-L-histidine N-tele-methyltransferase activity toward RPL3."; /evidence="ECO:0000269|PubMed:33693809"; MUTAGEN 193..197; /note="DLGCG->KLRCR: Abolished protein-L-histidine N-tele-methyltransferase activity."; /evidence="ECO:0000269|PubMed:35674491"; MUTAGEN 217; /note="D->A: Loss of protein-L-histidine N-tele-methyltransferase activity."; /evidence="ECO:0000269|PubMed:33693809"; MUTAGEN 250..251; /note="KR->GG: Decreased localization to the nucleus."; /evidence="ECO:0000269|PubMed:33693809
uniprot
proteins
post_translational_modification
PTM: Monomethylated at His-154 through automethylation (PubMed:33693809). Automethylation at His-154 positively regulates the methyltransferase activity toward RPL3 (PubMed:33693809). Probably methylated on other residues (PubMed:33693809). {ECO:0000269|PubMed:33693809}.
uniprot
proteins
protein_family
METTL18 family
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23349634
uniprot
proteins
pubmed
33693809
uniprot
proteins
pubmed
35674491
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:33693809}. Nucleus {ECO:0000269|PubMed:33693809}. Nucleus, nucleolus {ECO:0000269|PubMed:33693809}.
uniprot
proteins