Gramd1b
entrez
235283
canonical
uniprot
Q80TI0
canonical
ensembl
ENSMUSG00000040111
resolver
ensp
ENSMUSP00000048126
resolver
ensp
ENSMUSP00000112417
resolver
ensp
ENSMUSP00000112489
resolver
ensp
ENSMUSP00000112564
resolver
ensp
ENSMUSP00000130050
resolver
ensp
ENSMUSP00000148499
resolver
ensp
ENSMUSP00000148890
resolver
ensp
ENSMUSP00000300480
resolver
ensp
ENSMUSP00000300481
resolver
enst
ENSMUST00000119373
resolver
enst
ENSMUST00000216821
resolver
genesymbol
Gramd1b
resolver
genesymbol_syn
Kiaa1201
resolver
uniprot
A0A1L1SQ42
resolver
uniprot
D3YWR0
resolver
uniprot
Q6NS56
resolver
uniprot
Q8BZZ1
resolver
uniprot
Q9CTQ2
resolver
uniprot_entry
A0A1L1SQ42_MOUSE
resolver
uniprot_entry
ASTRB_MOUSE
resolver
uniprot_entry
D3YWR0_MOUSE
resolver
uniprot_sec
Q6NS56
resolver
uniprot_sec
Q8BZZ1
resolver
uniprot_sec
Q9CTQ2
resolver
amino_acid_sequence
MKGFKLSCTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDDDFNTMGYCEEIPIEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFDGLPLEEEVMEGDGSLEKELAIDNIIGEKIEIMAPVTSPSLDFNDNEDIPTELSDSSDTHDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFLRDFMEQRRFSDIIFHPWKKEENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVARNKSRLRVSTELRYRKQPWGFVKTFIEKNFWSGLEDYFRHLETELTKTESTYLAEIHRQSPKEKASKSSAVRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAGSTQTRHIPEDTPDGFHLQSVSKLLLVISCVICFSLVLLVVLNMMLFYKLWMLEYTTQTLTAWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVLLLDQMKDSLINLQNGIRSRDYTAESDEKRNRYH
uniprot
proteins
function
FUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (PubMed:30220461). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (PubMed:30220461). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (PubMed:30220461). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (PubMed:30220461). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (PubMed:30220461). Also mediates cholesterol transfer from lysosomes to endoplasmic reticulum through interaction with NPC1 (By similarity). {ECO:0000250|UniProtKB:Q3KR37, ECO:0000269|PubMed:30220461}.
uniprot
proteins
mass_dalton
85355
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30220461
uniprot
proteins
sequence_length
738
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30220461}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30220461}; Single-pass membrane protein {ECO:0000255}. Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS). {ECO:0000269|PubMed:30220461}.
uniprot
proteins
transmembrane_region
TRANSMEM 623..643; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins