Ier5
entrez
15939
canonical
uniprot
O89113
canonical
ensembl
ENSMUSG00000056708
resolver
ensp
ENSMUSP00000056948
resolver
enst
ENSMUST00000055322
resolver
genesymbol
Ier5
resolver
uniprot
Q3UJ54
resolver
uniprot
Q8CGI0
resolver
uniprot_entry
IER5_MOUSE
resolver
uniprot_entry
Q3UJ54_MOUSE
resolver
uniprot_sec
Q8CGI0
resolver
amino_acid_sequence
MEFKLEAHRIVSISLGKIYNSRVQRGGIKLHKNLLVSLVLRSARQVYLSDPCPGLYLAGPAGTPAVPPPQQPGEPVAGPPSGWGEPPPPVARAAWPEPEPQPQPQPQRPSVCHTPGAGSSEPVAAVAGSGEALRGGEEDSAAAAWGRVERPRAASSGGGSDACPEGPRAVRRPCGCPPAVEERSSEDGSPAPPAPCPRKRGAAGVGGGRASCSAPGSTPLKKPRRNSEEQPVTGEDDTDEEMETGNVANLISIFGSSFSGLLRKSPAGGREEEEAEEGGPEAAEPGQICCDKPVLRDMSPWSTAIVAF
uniprot
proteins
function
FUNCTION: Plays a role as a transcription factor. Mediates positive transcriptional regulation of several chaperone gene during the heat shock response in a HSF1-dependent manner. Mediates negative transcriptional regulation of CDC25B expression. Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A. Involved in the regulation of cell proliferation and resistance to thermal stress. Involved in the cell cycle checkpoint and survival in response to ionizing radiation. Associates with chromatin to the CDC25B promoter. {ECO:0000250|UniProtKB:Q5VY09}.
uniprot
proteins
mass_dalton
31784
uniprot
proteins
protein_family
IER family
uniprot
proteins
pubmed
10049588
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5VY09}. Cytoplasm {ECO:0000250|UniProtKB:Q5VY09}. Note=Predominantly cytoplasmic. Translocated in the nucleus during heat shock. {ECO:0000250|UniProtKB:Q5VY09}.
uniprot
proteins