Pnpla7
entrez
241274
canonical
uniprot
A2AJ88
canonical
ensembl
ENSMUSG00000036833
resolver
ensp
ENSMUSP00000044078
resolver
ensp
ENSMUSP00000325066
resolver
ensp
ENSMUSP00000325070
resolver
ensp
ENSMUSP00000325071
resolver
genesymbol
Pnpla7
resolver
uniprot
A9YTK0
resolver
uniprot
B0LS74
resolver
uniprot
B0ZTC6
resolver
uniprot
B9EJ75
resolver
uniprot
Q3TD21
resolver
uniprot
Q3UFP1
resolver
uniprot
Q66JS2
resolver
uniprot
Q6P3F9
resolver
uniprot
Q8BTY7
resolver
uniprot
Q8R064
resolver
uniprot
Q8R3C5
resolver
uniprot_entry
PLPL7_MOUSE
resolver
uniprot_sec
A9YTK0
resolver
uniprot_sec
B0LS74
resolver
uniprot_sec
B0ZTC6
resolver
uniprot_sec
B9EJ75
resolver
uniprot_sec
Q3TD21
resolver
uniprot_sec
Q3UFP1
resolver
uniprot_sec
Q66JS2
resolver
uniprot_sec
Q6P3F9
resolver
uniprot_sec
Q8BTY7
resolver
uniprot_sec
Q8R064
resolver
uniprot_sec
Q8R3C5
resolver
activity_regulation
ACTIVITY REGULATION: cAMP does not regulate lysophospholipase activity in vitro (PubMed:18086666, PubMed:28887301). Slightly inhibited by organophosphorus (OP) compounds such as mipafox, which is likely why mice are less sensitive to distal axonophathy induced by OPs compared to humans (PubMed:18086666). {ECO:0000269|PubMed:18086666, ECO:0000269|PubMed:28887301}.
uniprot
proteins
amino_acid_sequence
MQNEEDACLEAGYCLGTTLSSWRLHFMEEQSQSTMLMGIGIGALLTLAFVGITFFFVYRRVRRLRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSARAAVSSTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSLRPSEFSSSDHGSSCVTVSGPLLKRSCSVPLPSNHGEVDELRQSQGSGSNTSAFQESHEGATSDLGMAYNRARILPHSDEQLGNSLASKSKKSVVAETPSAIFHYSENFRDETGACGKTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTLVSKQGDQDVNILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVKRMSSFVRQIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSATGHQLGFNTASSKWDLGNPPGNLSTVAALPASEDVPLTAFALELQHALSAIGPVLLLTSDNIKQRLGSAALDSIHEYRLSSWLGQQEDIHRIVLYQADGTLTPWTQRCIRQADCILIVGLGEQEPAVGELEQMLESTAVRAQKQLILLHKEDGPVPSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPKLVEMYTRVFQRPPDRHSDFSRLARMLTGNAIALVLGGGGARGCAQVGILRALAECGVPVDIIGGTSIGAFMGALFAEERSYSQTRIRAKQWAEGMTSMMKTILDLTYPITSMFSGTGFNSSISNIFKDRQIEDLWLPYFAITTDITASAMRVHTDGSLWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGRTVFDIWVRSGVLEKMLQDQQGTSKRKDCGVFTCPNSSFTDLAEIVSRIEPAKVAAVDDESDYQTEYEEELPAIPKETYADFQSTGIELDSDSEYEPSMLQGPPSLTSPEQSQDSFPWLPNQDDQGPRLEHPS
uniprot
proteins
ec_number
3.1.1.-
uniprot
proteins
ec_number
3.1.1.5
uniprot
proteins
function
FUNCTION: Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine (PubMed:18086666, PubMed:28887301). Can also deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and lysophosphatidic acid (C16:0) (PubMed:18086666, PubMed:22326266, PubMed:28887301). {ECO:0000269|PubMed:18086666, ECO:0000269|PubMed:22326266, ECO:0000269|PubMed:28887301}.; FUNCTION: [Isoform 2]: Lysophospholipase. {ECO:0000269|PubMed:22326266}.; FUNCTION: [Isoform 3]: Lacks lysophospholipase activity. {ECO:0000269|PubMed:22326266}.
uniprot
proteins
mass_dalton
150494
uniprot
proteins
protein_family
NTE family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18086666
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22326266
uniprot
proteins
pubmed
28887301
uniprot
proteins
sequence_length
1352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18086666, ECO:0000269|PubMed:28887301}; Single-pass type III membrane protein {ECO:0000269|PubMed:28887301}. Lipid droplet {ECO:0000269|PubMed:18086666, ECO:0000269|PubMed:28887301}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22326266}; Single-pass type III membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22326266}; Single-pass type III membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22326266}; Single-pass type III membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..57; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins