CASP1
entrez
834
canonical
uniprot
P29466
canonical
ensembl
ENSG00000137752
resolver
ensp
ENSP00000410076
resolver
ensp
ENSP00000433138
resolver
ensp
ENSP00000434250
resolver
ensp
ENSP00000434303
resolver
ensp
ENSP00000434779
resolver
ensp
ENSP00000436875
resolver
ensp
ENSP00000512114
resolver
ensp
ENSP00000512117
resolver
genesymbol
CASP1
resolver
genesymbol_syn
IL1BC
resolver
genesymbol_syn
IL1BCE
resolver
hgnc
HGNC:1499
resolver
uniprot
A8K249
resolver
uniprot
A8K257
resolver
uniprot
B5MDZ1
resolver
uniprot
Q53EY6
resolver
uniprot
Q6DMQ1
resolver
uniprot
Q6GSS3
resolver
uniprot
Q6PI75
resolver
uniprot
Q9UCN3
resolver
uniprot_entry
A8K249_HUMAN
resolver
uniprot_entry
A8K257_HUMAN
resolver
uniprot_entry
CASP1_HUMAN
resolver
uniprot_sec
B5MDZ1
resolver
uniprot_sec
Q53EY6
resolver
uniprot_sec
Q6DMQ1
resolver
uniprot_sec
Q6GSS3
resolver
uniprot_sec
Q6PI75
resolver
uniprot_sec
Q9UCN3
resolver
activity_regulation
ACTIVITY REGULATION: (Microbial infection) Specifically inhibited by the cowpox virus Crma protein. {ECO:0000269|PubMed:1339309}.
uniprot
proteins
amino_acid_sequence
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
uniprot
proteins
ec_number
3.4.22.36
uniprot
proteins
function
FUNCTION: Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides (PubMed:15326478, PubMed:15498465, PubMed:1574116, PubMed:26375003, PubMed:32051255, PubMed:37993714, PubMed:7876192, PubMed:9334240). Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes (PubMed:15326478, PubMed:15498465, PubMed:1574116, PubMed:32051255, PubMed:7876192). Cleaves a tetrapeptide after an Asp residue at position P1 (PubMed:15498465, PubMed:1574116, PubMed:7876192). Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD (PubMed:26375003). In contrast to cleavage of interleukin IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32051255, PubMed:32109412, PubMed:32553275). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (PubMed:22464733). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590). In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly (PubMed:20197547). {ECO:0000269|PubMed:15326478, ECO:0000269|PubMed:15498465, ECO:0000269|PubMed:1574116, ECO:0000269|PubMed:20197547, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:32051255, ECO:0000269|PubMed:32109412, ECO:0000269|PubMed:32553275, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7876192, ECO:0000269|PubMed:9334240}.; FUNCTION: [Isoform Delta]: Apoptosis inactive. {ECO:0000269|PubMed:7876192}.; FUNCTION: [Isoform Epsilon]: Apoptosis inactive. {ECO:0000269|PubMed:7876192}.
uniprot
proteins
mass_dalton
45159
uniprot
proteins
mutagenesis
MUTAGEN 285; /note="C->A,S: Loss of protease activity. Loss of SPHK2 cleavage and release in apoptotic cells."; /evidence="ECO:0000269|PubMed:15498465, ECO:0000269|PubMed:20197547, ECO:0000269|PubMed:32051255, ECO:0000269|PubMed:32109412, ECO:0000269|PubMed:32553275"; MUTAGEN 294; /note="W->A: Mediates autoprocessing but is unable to interact with Gasdermin-D (GSDMD) and mediate its cleavage."; /evidence="ECO:0000269|PubMed:32109412, ECO:0000269|PubMed:32553275"; MUTAGEN 297; /note="D->N: In IDL(uncl); abolished cleavage in the interdomain region; when associated with 315-N-N-316."; /evidence="ECO:0000269|PubMed:32051255"; MUTAGEN 315..316; /note="DD->NN: In IDL(uncl); abolished cleavage in the interdomain region; when associated with N-297."; /evidence="ECO:0000269|PubMed:32051255"; MUTAGEN 318..320; /note="IKK->AKA: Abolished ability to cleave IL18."; /evidence="ECO:0000269|PubMed:37993714"; MUTAGEN 318; /note="I->N: Mediates autoprocessing but is unable to interact with Gasdermin-D (GSDMD) and mediate its cleavage."; /evidence="ECO:0000269|PubMed:32109412, ECO:0000269|PubMed:32553275"; MUTAGEN 320; /note="K->A: Abolishes cleavage of Gasdermin-D (GSDMD)."; /evidence="ECO:0000269|PubMed:32553275
uniprot
proteins
post_translational_modification
PTM: The two subunits are derived from the precursor sequence by an autocatalytic mechanism. {ECO:0000269|PubMed:32109412, ECO:0000269|PubMed:8044845}.; PTM: Ubiquitinated via 'Lys-11'-linked polyubiquitination. Deubiquitinated by USP8. {ECO:0000269|PubMed:30065070}.; PTM: Cleavage in the interdomain linker region is required to induce pyroptosis. {ECO:0000269|PubMed:32051255}.
uniprot
proteins
protein_family
Peptidase C14A family
uniprot
proteins
pubmed
11051551
uniprot
proteins
pubmed
1321594
uniprot
proteins
pubmed
1339309
uniprot
proteins
pubmed
1373520
uniprot
proteins
pubmed
15030775
uniprot
proteins
pubmed
15296730
uniprot
proteins
pubmed
15326478
uniprot
proteins
pubmed
15383541
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498465
uniprot
proteins
pubmed
1574116
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16785446
uniprot
proteins
pubmed
20148899
uniprot
proteins
pubmed
20197547
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22464733
uniprot
proteins
pubmed
26375003
uniprot
proteins
pubmed
28314590
uniprot
proteins
pubmed
30065070
uniprot
proteins
pubmed
30692621
uniprot
proteins
pubmed
32051255
uniprot
proteins
pubmed
32109412
uniprot
proteins
pubmed
32553275
uniprot
proteins
pubmed
33420033
uniprot
proteins
pubmed
37993714
uniprot
proteins
pubmed
7876192
uniprot
proteins
pubmed
8044845
uniprot
proteins
pubmed
9190289
uniprot
proteins
pubmed
9334240
uniprot
proteins
pubmed
9987822
uniprot
proteins
sequence_length
404
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20197547}. Cell membrane {ECO:0000269|PubMed:20197547}.
uniprot
proteins