CLASP1
entrez
23332
canonical
uniprot
Q7Z460
canonical
ensembl
ENSG00000074054
resolver
ensp
ENSP00000263710
resolver
ensp
ENSP00000386442
resolver
ensp
ENSP00000389372
resolver
ensp
ENSP00000400562
resolver
ensp
ENSP00000441625
resolver
ensp
ENSP00000512981
resolver
ensp
ENSP00000515167
resolver
ensp
ENSP00000547466
resolver
ensp
ENSP00000631967
resolver
ensp
ENSP00000631968
resolver
ensp
ENSP00000631971
resolver
ensp
ENSP00000631983
resolver
ensp
ENSP00000631984
resolver
ensp
ENSP00000631988
resolver
enst
ENST00000696935
resolver
enst
ENST00000700755
resolver
genesymbol
CLASP1
resolver
genesymbol_syn
KIAA0622
resolver
genesymbol_syn
MAST1
resolver
hgnc
HGNC:17088
resolver
uniprot
A0A8V8TLP7
resolver
uniprot
A0A8V8TRF6
resolver
uniprot
A2RU21
resolver
uniprot
B7ZLX3
resolver
uniprot
F5GWS0
resolver
uniprot
O75118
resolver
uniprot
Q2KHQ9
resolver
uniprot
Q5H9P0
resolver
uniprot
Q8N5B8
resolver
uniprot
Q9BQT5
resolver
uniprot_entry
A0A8V8TLP7_HUMAN
resolver
uniprot_entry
A0A8V8TRF6_HUMAN
resolver
uniprot_entry
CLAP1_HUMAN
resolver
uniprot_sec
A2RU21
resolver
uniprot_sec
B7ZLX3
resolver
uniprot_sec
F5GWS0
resolver
uniprot_sec
O75118
resolver
uniprot_sec
Q2KHQ9
resolver
uniprot_sec
Q5H9P0
resolver
uniprot_sec
Q8N5B8
resolver
uniprot_sec
Q9BQT5
resolver
amino_acid_sequence
MEPRMESCLAQVLQKDVGKRLQVGQELIDYFSDKQKSADLEHDQTMLDKLVDGLATSWVNSSNYKVVLLGMDILSALVTRLQDRFKAQIGTVLPSLIDRLGDAKDSVREQDQTLLLKIMDQAANPQYVWDRMLGGFKHKNFRTREGICLCLIATLNASGAQTLTLSKIVPHICNLLGDPNSQVRDAAINSLVEIYRHVGERVRADLSKKGLPQSRLNVIFTKFDEVQKSGNMIQSANDKNFDDEDSVDGNRPSSASSTSSKAPPSSRRNVGMGTTRRLGSSTLGSKSSAAKEGAGAVDEEDFIKAFDDVPVVQIYSSRDLEESINKIREILSDDKHDWEQRVNALKKIRSLLLAGAAEYDNFFQHLRLLDGAFKLSAKDLRSQVVREACITLGHLSSVLGNKFDHGAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRHTHIPRLIPVITSNCTSKSVAVRRRCFEFLDLLLQEWQTHSLERHISVLAETIKKGIHDADSEARIEARKCYWGFHSHFSREAEHLYHTLESSYQKALQSHLKNSDSIVSLPQSDRSSSSSQESLNRPLSAKRSPTGSTTSRASTVSTKSVSTTGSLQRSRSDIDVNAAASAKSKVSSSSGTTPFSSAAALPPGSYASLGRIRTRRQSSGSATNVASTPDNRGRSRAKVVSQSQRSRSANPAGAGSRSSSPGKLLGSGYGGLTGGSSRGPPVTPSSEKRSKIPRSQGCSRETSPNRIGLARSSRIPRPSMSQGCSRDTSRESSRDTSPARGFPPLDRFGLGQPGRIPGSVNAMRVLSTSTDLEAAVADALKKPVRRRYEPYGMYSDDDANSDASSVCSERSYGSRNGGIPHYLRQTEDVAEVLNHCASSNWSERKEGLLGLQNLLKSQRTLSRVELKRLCEIFTRMFADPHSKRVFSMFLETLVDFIIIHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRDSFPFDQQFNILMRFIVDQTQTPNLKVKVAILKYIESLARQMDPTDFVNSSETRLAVSRIITWTTEPKSSDVRKAAQIVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLKNSSNTSVGSPSNTIGRTPSRHTSSRTSPLTSPTNCSHGGLSPSRLWGWSADGLAKHPPPFSQPNSIPTAPSHKALRRSYSPSMLDYDTENLNSEEIYSSLRGVTEAIEKFSFRSQEDLNEPIKRDGKKECDIVSRDGGAASPATEGRGGSEVEGGRTALDNKTSLLNTQPPRAFPGPRARDYNPYPYSDAINTYDKTALKEAVFDDDMEQLRDVPIDHSDLVADLLKELSNHNERVEERKGALLELLKITREDSLGVWEEHFKTILLLLLETLGDKDHSIRALALRVLREILRNQPARFKNYAELTIMKTLEAHKDSHKEVVRAAEEAASTLASSIHPEQCIKVLCPIIQTADYPINLAAIKMQTKVVERIAKESLLQLLVDIIPGLLQGYDNTESSVRKASVFCLVAIYSVIGEDLKPHLAQLTGSKMKLLNLYIKRAQTTNSNSSSSSDVSTHS
uniprot
proteins
function
FUNCTION: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}.
uniprot
proteins
mass_dalton
169451
uniprot
proteins
protein_family
CLASP family
uniprot
proteins
pubmed
11290329
uniprot
proteins
pubmed
12837247
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15631994
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16145243
uniprot
proteins
pubmed
16824950
uniprot
proteins
pubmed
16866869
uniprot
proteins
pubmed
16914514
uniprot
proteins
pubmed
17543864
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
33587225
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
1538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network {ECO:0000305}. Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.
uniprot
proteins