Foxd3
entrez
15221
canonical
uniprot
Q61060
canonical
ensembl
ENSMUSG00000067261
resolver
ensp
ENSMUSP00000084541
resolver
enst
ENSMUST00000087285
resolver
genesymbol
Foxd3
resolver
genesymbol_syn
Hfh2
resolver
uniprot
A2BDY3
resolver
uniprot_entry
A2BDY3_MOUSE
resolver
uniprot_entry
FOXD3_MOUSE
resolver
amino_acid_sequence
MTLSGSGSASDMSGQTVLTAEDVDIDVVGEGDDGLEEKDSDAGCDSPAGPPDLRLDEADEGPPVSAHHGQSQPQALALPTEATGPGNDTGAPEADGCKGGEDAVTGGGGPGAGSGATGGLTPNKPKNSLVKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQEHLREQTALMMQSFGAYSLAAAAGAGPYGLHPAAAAGAYSHPAAAAAAAAAAALQYPYALPPVAPVLPPAVPLLPSGELGRKAAAFGSQLGPSLQLQLNTLGAAAAAAGTAGAAGTTSLIKSEPSARPSFSIENIIGAGSAAPGGSAGGGGSGGGAGGGGGSGGGGGAQSFLRPPGTVQSAALMATHQPLSLSRTTATIAPILSVPLSGQFLQPAASAAAAAAAAVQAKWPAQ
uniprot
proteins
function
FUNCTION: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor (PubMed:12381664, PubMed:8798505). Also acts as a transcriptional activator (PubMed:12381664, PubMed:8798505). Negatively regulates transcription of transcriptional repressor Rhit/Zfp13 (By similarity). Promotes development of neural crest cells from neural tube progenitors (PubMed:12381664, PubMed:8798505). Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation (PubMed:12381664, PubMed:8798505). Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis (PubMed:12381664, PubMed:8798505). {ECO:0000250|UniProtKB:Q9UJU5, ECO:0000269|PubMed:12381664, ECO:0000269|PubMed:8798505}.
uniprot
proteins
mass_dalton
46345
uniprot
proteins
pubmed
11684651
uniprot
proteins
pubmed
12381664
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8798505
uniprot
proteins
pubmed
9767163
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins