Pax5
entrez
18507
canonical
uniprot
Q02650
canonical
ensembl
ENSMUSG00000014030
resolver
ensp
ENSMUSP00000014174
resolver
enst
ENSMUST00000014174
resolver
genesymbol
Pax5
resolver
genesymbol_syn
Pax-5
resolver
uniprot_entry
PAX5_MOUSE
resolver
amino_acid_sequence
MDLEKNYPTPRTIRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLTSPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSPAARGAAPPAAATAYDRH
uniprot
proteins
function
FUNCTION: Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:9042861). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:16546096). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:16546096, PubMed:9042861). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (By similarity). {ECO:0000250|UniProtKB:Q02548, ECO:0000269|PubMed:16546096, ECO:0000269|PubMed:9042861}.
uniprot
proteins
mass_dalton
42231
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000305}.; PTM: Phosphorylated by SYK. This phosphorylation plays an important role in the abolition of BLIMP1 repression by PAX5 in order to trigger plasma cell differentiation. {ECO:0000250|UniProtKB:Q02548}.
uniprot
proteins
pubmed
11799127
uniprot
proteins
pubmed
1516825
uniprot
proteins
pubmed
16546096
uniprot
proteins
pubmed
1685142
uniprot
proteins
pubmed
9042861
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02548}.
uniprot
proteins