EPHA3
entrez
2042
canonical
uniprot
P29320
canonical
ensembl
ENSG00000044524
resolver
ensp
ENSP00000337451
resolver
ensp
ENSP00000399926
resolver
ensp
ENSP00000419190
resolver
ensp
ENSP00000530988
resolver
ensp
ENSP00000731693
resolver
enst
ENST00000494014
resolver
genesymbol
EPHA3
resolver
genesymbol_syn
ETK
resolver
genesymbol_syn
ETK1
resolver
genesymbol_syn
HEK
resolver
genesymbol_syn
TYRO4
resolver
hgnc
HGNC:3387
resolver
uniprot
A0A140VJJ0
resolver
uniprot
C9JXA2
resolver
uniprot
Q6P4R6
resolver
uniprot
Q9H2V3
resolver
uniprot
Q9H2V4
resolver
uniprot_entry
A0A140VJJ0_HUMAN
resolver
uniprot_entry
C9JXA2_HUMAN
resolver
uniprot_entry
EPHA3_HUMAN
resolver
uniprot_entry
Q6P4R6_HUMAN
resolver
uniprot_sec
Q9H2V3
resolver
uniprot_sec
Q9H2V4
resolver
amino_acid_sequence
MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPMDSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPGFYKALDGNMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSMACTRPPSSPRNVISNINETSVILDWSWPLDTGGRKDVTFNIICKKCGWNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSSPPRQFAAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVVIYVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKALETQSKNGPVPV
uniprot
proteins
disease_involvement
DISEASE: Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. {ECO:0000269|PubMed:12738854}. Note=The gene represented in this entry may be involved in disease pathogenesis.
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (PubMed:11870224, PubMed:12794130). Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5 (By similarity). Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration (PubMed:11870224). Also activated by EFNA1, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development (PubMed:12794130). Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development (By similarity). {ECO:0000250|UniProtKB:P29319, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:12794130}.
uniprot
proteins
mass_dalton
110131
uniprot
proteins
mutagenesis
MUTAGEN 133; /note="V->E: Loss of EFNA5-binding ability and function."; /evidence="ECO:0000269|PubMed:14660665"; MUTAGEN 152; /note="F->L: Loss of EFNA5-binding ability and function."; /evidence="ECO:0000269|PubMed:14660665"; MUTAGEN 596; /note="Y->F: 10-fold suppression of kinase activity; when associated with F-602. Full kinase activity; when associated with F-602 and F-742. Full kinase activity; when associated with F-602 and A-768."; /evidence="ECO:0000269|PubMed:18547520"; MUTAGEN 602; /note="Y->F: 10-fold suppression of kinase activity; when associated with F-596. Full kinase activity; when associated with F-596 and F-742. Full kinase activity; when associated with F-596 and A-768."; /evidence="ECO:0000269|PubMed:18547520"; MUTAGEN 742; /note="Y->F: Full kinase activity; when associated with F-596 and F-602."; /evidence="ECO:0000269|PubMed:18547520"; MUTAGEN 768; /note="S->A: Full kinase activity; when associated with F-596 and F-602."; /evidence="ECO:0000269|PubMed:18547520
uniprot
proteins
post_translational_modification
PTM: Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN1. {ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:18547520, ECO:0000269|PubMed:21135139}.
uniprot
proteins
protein_family
Ephrin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10987298
uniprot
proteins
pubmed
11870224
uniprot
proteins
pubmed
12738854
uniprot
proteins
pubmed
12794130
uniprot
proteins
pubmed
1311845
uniprot
proteins
pubmed
14660665
uniprot
proteins
pubmed
15901737
uniprot
proteins
pubmed
16239146
uniprot
proteins
pubmed
16941478
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
1737782
uniprot
proteins
pubmed
18547520
uniprot
proteins
pubmed
20838624
uniprot
proteins
pubmed
21135139
uniprot
proteins
pubmed
9267020
uniprot
proteins
sequence_length
983
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:11870224}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:21135139}.
uniprot
proteins
transmembrane_region
TRANSMEM 542..565; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins