Camk2b
entrez
12323
canonical
uniprot
P28652
canonical
ensembl
ENSMUSG00000057897
resolver
ensp
ENSMUSP00000002817
resolver
ensp
ENSMUSP00000019133
resolver
ensp
ENSMUSP00000087925
resolver
ensp
ENSMUSP00000099120
resolver
ensp
ENSMUSP00000105437
resolver
ensp
ENSMUSP00000105438
resolver
ensp
ENSMUSP00000227709
resolver
ensp
ENSMUSP00000227711
resolver
ensp
ENSMUSP00000227712
resolver
ensp
ENSMUSP00000227713
resolver
ensp
ENSMUSP00000227724
resolver
ensp
ENSMUSP00000227725
resolver
ensp
ENSMUSP00000227727
resolver
ensp
ENSMUSP00000227729
resolver
ensp
ENSMUSP00000227730
resolver
ensp
ENSMUSP00000227731
resolver
ensp
ENSMUSP00000227734
resolver
ensp
ENSMUSP00000227745
resolver
ensp
ENSMUSP00000227746
resolver
ensp
ENSMUSP00000227752
resolver
ensp
ENSMUSP00000227773
resolver
ensp
ENSMUSP00000227780
resolver
ensp
ENSMUSP00000227785
resolver
ensp
ENSMUSP00000344691
resolver
enst
ENSMUST00000002817
resolver
enst
ENSMUST00000019133
resolver
enst
ENSMUST00000090443
resolver
enst
ENSMUST00000101586
resolver
enst
ENSMUST00000109812
resolver
enst
ENSMUST00000109813
resolver
genesymbol
Camk2b
resolver
genesymbol_syn
Camk2d
resolver
uniprot
F6R2Q9
resolver
uniprot
Q5SVH9
resolver
uniprot
Q5SVI0
resolver
uniprot
Q5SVI2
resolver
uniprot
Q5SVJ0
resolver
uniprot
Q5SVJ1
resolver
uniprot
Q68EG2
resolver
uniprot
Q8BL41
resolver
uniprot_entry
F6R2Q9_MOUSE
resolver
uniprot_entry
KCC2B_MOUSE
resolver
uniprot_entry
Q5SVI0_MOUSE
resolver
uniprot_entry
Q5SVI2_MOUSE
resolver
uniprot_entry
Q5SVJ0_MOUSE
resolver
uniprot_entry
Q5SVJ1_MOUSE
resolver
uniprot_entry
Q68EG2_MOUSE
resolver
uniprot_entry
Q8BL41_MOUSE
resolver
uniprot_sec
Q5SVH9
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
uniprot
proteins
amino_acid_sequence
MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTKNSSAITSPKGSLPPAALEPQTTVIHNPVDGIKESSDSTNTTIEDEDAKARKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2 (PubMed:21752990). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Thr-134' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (By similarity). {ECO:0000250|UniProtKB:P08413, ECO:0000250|UniProtKB:Q13554, ECO:0000269|PubMed:21752990, ECO:0000269|PubMed:29100089}.
uniprot
proteins
mass_dalton
60461
uniprot
proteins
mutagenesis
MUTAGEN 303; /note="A->R: Blocks calcium/calmodulin binding."; /evidence="ECO:0000269|PubMed:21752990
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
1321343
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21752990
uniprot
proteins
pubmed
23805378
uniprot
proteins
pubmed
29100089
uniprot
proteins
sequence_length
542
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Sarcoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Synapse {ECO:0000250|UniProtKB:P08413}.
uniprot
proteins