Cideb
entrez
12684
canonical
uniprot
O70303
canonical
ensembl
ENSMUSG00000022219
resolver
ensp
ENSMUSP00000001497
resolver
enst
ENSMUST00000001497
resolver
genesymbol
Cideb
resolver
uniprot
Q3V4D3
resolver
uniprot
Q91X39
resolver
uniprot_entry
CIDEB_MOUSE
resolver
uniprot_entry
Q3V4D3_MOUSE
resolver
uniprot_sec
Q91X39
resolver
amino_acid_sequence
MEYLSAFNPNGLLRSVSTVSSELSRRVWNSAPPPQRPFRVCDHKRTVRKGLTAASLQELLDKVLETLLLRGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLEQGQSWSPKSGMLSYGLGREKPKHSKDIARITFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGVGPKRVLRELLRWTSSLLQGLGHMLLGISSTLRHVVEGADRWQWHGQRHLHS
uniprot
proteins
function
FUNCTION: Lipid transferase specifically expressed in hepatocytes, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:26733203). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:26733203). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (By similarity). Promotes lipid exchange and lipid droplet fusion in both small and large lipid droplet-containing hepatocytes (PubMed:26733203). In addition to its role in lipid droplet fusion, also involved in cytoplasmic vesicle biogenesis and transport (PubMed:19187774, PubMed:23297397, PubMed:30858281). Required for very-low-density lipoprotein (VLDL) lipidation and maturation (PubMed:19187774, PubMed:23297397). Probably involved in the biogenesis of VLDL transport vesicles by forming a COPII vesicle coat and facilitating the formation of endoplasmic reticulum-derived large vesicles (PubMed:23297397). Also involved in sterol-regulated export of the SCAP-SREBP complex, composed of SCAP, SREBF1/SREBP1 and SREBF2/SREBP2, by promoting loading of SCAP-SREBP into COPII vesicles (PubMed:30858281). May also activate apoptosis (PubMed:9564035). {ECO:0000250|UniProtKB:P56198, ECO:0000269|PubMed:19187774, ECO:0000269|PubMed:23297397, ECO:0000269|PubMed:26733203, ECO:0000269|PubMed:30858281, ECO:0000269|PubMed:9564035}.
uniprot
proteins
mass_dalton
24800
uniprot
proteins
mutagenesis
MUTAGEN 128; /note="K->A: Abolished interaction with PREB."; /evidence="ECO:0000269|PubMed:30858281
uniprot
proteins
protein_family
CIDE family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17646209
uniprot
proteins
pubmed
19187774
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23297397
uniprot
proteins
pubmed
26733203
uniprot
proteins
pubmed
30858281
uniprot
proteins
pubmed
9564035
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:19187774, ECO:0000269|PubMed:26733203}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19187774, ECO:0000269|PubMed:23297397}; Peripheral membrane protein {ECO:0000269|PubMed:19187774}; Cytoplasmic side {ECO:0000269|PubMed:19187774}. Golgi apparatus {ECO:0000269|PubMed:23297397}. Cytoplasmic vesicle, COPI-coated vesicle {ECO:0000269|PubMed:23297397, ECO:0000269|PubMed:30858281}. Note=Enriched at lipid droplet contact sites. {ECO:0000269|PubMed:26733203}.
uniprot
proteins