Stim1
entrez
361618
canonical
uniprot
P84903
canonical
ensembl
ENSRNOG00000020425
resolver
ensp
ENSRNOP00000027685
resolver
ensp
ENSRNOP00000075979
resolver
ensp
ENSRNOP00000110413
resolver
enst
ENSRNOT00000027685
resolver
enst
ENSRNOT00000092882
resolver
enst
ENSRNOT00000125071
resolver
genesymbol
Stim1
resolver
genesymbol_syn
Sim
resolver
uniprot
A0A1B0GWQ1
resolver
uniprot
A0A8L2QER8
resolver
uniprot
A0ABK0M0K2
resolver
uniprot_entry
A0A1B0GWQ1_RAT
resolver
uniprot_entry
A0A8L2QER8_RAT
resolver
uniprot_entry
A0ABK0M0K2_RAT
resolver
uniprot_entry
STIM1_RAT
resolver
amino_acid_sequence
MDVCARLALWLLWGLLLHQGQSLSHSHSEKNTGASSGATSEESTEAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKASEVYNWTVDEVIQWLITYVELPQYEETFRKLQLTGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAERQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPAHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQHGLGSQRDLTHSDSESSLHTSDRQRVAPKPPQMGRAADEALNATSSNGSHRLIEGVHPGSLVEKLPDSPALAKKTILALNHGLDKAHSLMELNPSVPPGGSPLLDSSHSHSPSSPDPDTPSPVGDSRALQGSRNTRIPHLAGKKAMAEEDNGSIGEETDSSPGRKKFPLKIFKKPLKK
uniprot
proteins
function
FUNCTION: Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels. Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry. Involved in enamel formation. Plays a role in regulating the type I interferon response by retaining the signaling adapter STING at the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q13586, ECO:0000269|PubMed:16208375}.
uniprot
proteins
mass_dalton
77449
uniprot
proteins
mutagenesis
MUTAGEN 76; /note="D->A: Increases Ca(2+) influx through activation of CRAC channels, even when Ca(2+) stores are not depleted."; /evidence="ECO:0000269|PubMed:16208375"; MUTAGEN 78; /note="D->A: Increases Ca(2+) influx through activation of CRAC channels, even when Ca(2+) stores are not depleted."; /evidence="ECO:0000269|PubMed:16208375"; MUTAGEN 87; /note="E->Q: Increases Ca(2+) influx through activation of CRAC channels, even when Ca(2+) stores are not depleted."; /evidence="ECO:0000269|PubMed:16208375
uniprot
proteins
post_translational_modification
PTM: Glycosylation is required for cell surface expression. {ECO:0000250|UniProtKB:Q13586}.; PTM: Phosphorylated predominantly on Ser residues. {ECO:0000250|UniProtKB:Q13586}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16208375
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
685
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13586}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q13586}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q13586}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q13586}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q13586}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q13586}. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane. Associated with the microtubule network at the growing distal tip of microtubules. Colocalizes with ORAI1 at the cell membrane. Colocalizes preferentially with CASQ1 at endoplasmic reticulum in response to a depletion of intracellular calcium. {ECO:0000250|UniProtKB:Q13586}.
uniprot
proteins
transmembrane_region
TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins