TFCP2L1
entrez
29842
canonical
uniprot
Q9NZI6
canonical
ensembl
ENSG00000115112
resolver
ensp
ENSP00000263707
resolver
ensp
ENSP00000649765
resolver
ensp
ENSP00000649766
resolver
ensp
ENSP00000649772
resolver
enst
ENST00000263707
resolver
genesymbol
TFCP2L1
resolver
genesymbol_syn
CRTR1
resolver
genesymbol_syn
LBP9
resolver
hgnc
HGNC:17925
resolver
uniprot
Q4ZG43
resolver
uniprot_entry
TF2L1_HUMAN
resolver
uniprot_sec
Q4ZG43
resolver
amino_acid_sequence
MLFWHTQPEHYNQHNSGSYLRDVLALPIFKQEEPQLSPENEARLPPLQYVLCAATSPAVKLHEETLTYLNQGQSYEIRLLENRKLGDFQDLNTKYVKSIIRVVFHDRRLQYTEHQQLEGWRWSRPGDRILDIDIPLSVGILDPRASPTQLNAVEFLWDPAKRASAFIQVHCISTEFTPRKHGGEKGVPFRVQIDTFKQNENGEYTEHLHSASCQIKVFKPKGADRKQKTDREKMEKRTAQEKEKYQPSYETTILTECSPWPDVAYQVNSAPSPSYNGSPNSFGLGEGNASPTHPVEALPVGSDHLLPSASIQDAQQWLHRNRFSQFCRLFASFSGADLLKMSRDDLVQICGPADGIRLFNAIKGRNVRPKMTIYVCQELEQNRVPLQQKRDGSGDSNLSVYHAIFLEELTTLELIEKIANLYSISPQHIHRVYRQGPTGIHVVVSNEMVQNFQDESCFVLSTIKAESNDGYHIILKCGL
uniprot
proteins
function
FUNCTION: Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney (By similarity). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity). Also regulates the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity). JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity). Modulates the placental expression of CYP11A1 (PubMed:10644752). {ECO:0000250|UniProtKB:Q3UNW5, ECO:0000269|PubMed:10644752, ECO:0000269|PubMed:25215486, ECO:0000269|PubMed:26906118}.
uniprot
proteins
mass_dalton
54627
uniprot
proteins
mutagenesis
MUTAGEN 345; /note="D->G: Impairs the formation of oligomeric homo-complexes in solution."; /evidence="ECO:0000269|PubMed:26906118
uniprot
proteins
protein_family
CP2 subfamily
uniprot
proteins
protein_family
Grh/CP2 family
uniprot
proteins
pubmed
10644752
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
25215486
uniprot
proteins
pubmed
26906118
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10644752}.
uniprot
proteins