Cables1
entrez
63955
canonical
uniprot
Q9ESJ1
canonical
ensembl
ENSMUSG00000040957
resolver
ensp
ENSMUSP00000040639
resolver
ensp
ENSMUSP00000129463
resolver
enst
ENSMUST00000046948
resolver
enst
ENSMUST00000171109
resolver
genesymbol
Cables1
resolver
genesymbol_syn
Cables
resolver
uniprot
E9QNI6
resolver
uniprot
F7A4E7
resolver
uniprot
Q3TYS6
resolver
uniprot
Q3U148
resolver
uniprot
Q9EPR8
resolver
uniprot_entry
CABL1_MOUSE
resolver
uniprot_entry
F7A4E7_MOUSE
resolver
uniprot_entry
Q3TYS6_MOUSE
resolver
uniprot_entry
Q3U148_MOUSE
resolver
uniprot_sec
E9QNI6
resolver
uniprot_sec
Q9EPR8
resolver
amino_acid_sequence
MAAATATAGTAACSSSSSSRGGSTDAAATSGVQPPPPPPATAPPEPLRKPRMDPRRRQAALSFLTNISLDGRPPLQDHEWGGGEEGGGTKPGARARLSLLAAGCNAFSAPGTAAAPWTAGSGSSPCPLPPSLVPRVLGEPSQPPRSAPAVTGAQLQLPDGPGGAGQEELEEDDAFTNVQVPSASFLGSGTPGSTSGSRGRLNSFTQGILPIAFSRQNSQNYCALEQSGQGGSTSALEQLQRSRRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTKNGRDLKLDGGRQSAGAMSLKEIIGLEGVELGADGKTVSYTQFLLPTNAFGNRRNTIDSTASFSQFRSLSHRSLSMGRAGSTQGSLDAGSDLGDFMDYDPNLLDDPQWPCGKHKRVLTFPSYMTTVIDYVKPSDLKKDMNETFKEKFPHIKLTLSKIRSLKREMRKLAQEDCGFEEPTVAMAFVYFEKLALRGKLNKQNRKLCAGACVLLAAKVGSDLRKHEVKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLIQSS
uniprot
proteins
function
FUNCTION: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250, ECO:0000269|PubMed:11706030}.
uniprot
proteins
mass_dalton
61429
uniprot
proteins
mutagenesis
MUTAGEN 274; /note="S->A: Less efficiently phosphorylated in vitro."; /evidence="ECO:0000269|PubMed:11733001"; MUTAGEN 274; /note="S->T: Efficiently phosphorylated in vitro."; /evidence="ECO:0000269|PubMed:11733001
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-274 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3. {ECO:0000269|PubMed:10896159, ECO:0000269|PubMed:11733001}.
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
10873625
uniprot
proteins
pubmed
10896159
uniprot
proteins
pubmed
11527406
uniprot
proteins
pubmed
11585773
uniprot
proteins
pubmed
11706030
uniprot
proteins
pubmed
11733001
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cell projection, growth cone. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons.
uniprot
proteins