Il17ra
entrez
16172
canonical
uniprot
Q60943
canonical
ensembl
ENSMUSG00000002897
resolver
ensp
ENSMUSP00000002976
resolver
enst
ENSMUST00000002976
resolver
genesymbol
Il17ra
resolver
genesymbol_syn
Il17r
resolver
uniprot_entry
I17RA_MOUSE
resolver
amino_acid_sequence
MAIRRCWPRVVPGPALGWLLLLLNVLAPGRASPRLLDFPAPVCAQEGLSCRVKNSTCLDDSWIHPKNLTPSSPKNIYINLSVSSTQHGELVPVLHVEWTLQTDASILYLEGAELSVLQLNTNERLCVKFQFLSMLQHHRKRWRFSFSHFVVDPGQEYEVTVHHLPKPIPDGDPNHKSKIIFVPDCEDSKMKMTTSCVSSGSLWDPNITVETLDTQHLRVDFTLWNESTPYQVLLESFSDSENHSCFDVVKQIFAPRQEEFHQRANVTFTLSKFHWCCHHHVQVQPFFSSCLNDCLRHAVTVPCPVISNTTVPKPVADYIPLWVYGLITLIAILLVGSVIVLIICMTWRLSGADQEKHGDDSKINGILPVADLTPPPLRPRKVWIVYSADHPLYVEVVLKFAQFLITACGTEVALDLLEEQVISEVGVMTWVSRQKQEMVESNSKIIILCSRGTQAKWKAILGWAEPAVQLRCDHWKPAGDLFTAAMNMILPDFKRPACFGTYVVCYFSGICSERDVPDLFNITSRYPLMDRFEEVYFRIQDLEMFEPGRMHHVRELTGDNYLQSPSGRQLKEAVLRFQEWQTQCPDWFERENLCLADGQDLPSLDEEVFEDPLLPPGGGIVKQQPLVRELPSDGCLVVDVCVSEEESRMAKLDPQLWPQRELVAHTLQSMVLPAEQVPAAHVVEPLHLPDGSGAAAQLPMTEDSEACPLLGVQRNSILCLPVDSDDLPLCSTPMMSPDHLQGDAREQLESLMLSVLQQSLSGQPLESWPRPEVVLEGCTPSEEEQRQSVQSDQGYISRSSPQPPEWLTEEEELELGEPVESLSPEELRSLRKLQRQLFFWELEKNPGWNSLEPRRPTPEEQNPS
uniprot
proteins
function
FUNCTION: Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:20554964, PubMed:27923703, PubMed:8777726). Receptor for IL17F (PubMed:17911633, PubMed:20554964). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (By similarity). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (By similarity). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (By similarity). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (PubMed:20364087, PubMed:21993848). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (PubMed:18157131). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed:19144317). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity (PubMed:27795421). Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (PubMed:26735852). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21982598, PubMed:21993848, PubMed:21993849). {ECO:0000250|UniProtKB:Q96F46, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18157131, ECO:0000269|PubMed:19144317, ECO:0000269|PubMed:20364087, ECO:0000269|PubMed:20554964, ECO:0000269|PubMed:21982598, ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:21993849, ECO:0000269|PubMed:26735852, ECO:0000269|PubMed:27795421, ECO:0000269|PubMed:8777726}.; FUNCTION: (Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway. {ECO:0000269|PubMed:33723527}.
uniprot
proteins
mass_dalton
97808
uniprot
proteins
pubmed
17911633
uniprot
proteins
pubmed
18157131
uniprot
proteins
pubmed
19144317
uniprot
proteins
pubmed
20364087
uniprot
proteins
pubmed
20554964
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21982598
uniprot
proteins
pubmed
21993848
uniprot
proteins
pubmed
21993849
uniprot
proteins
pubmed
26735852
uniprot
proteins
pubmed
27795421
uniprot
proteins
pubmed
27923703
uniprot
proteins
pubmed
28813677
uniprot
proteins
pubmed
33723527
uniprot
proteins
pubmed
8777726
uniprot
proteins
sequence_length
864
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17911633}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 323..343; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins