GRM5
entrez
2915
canonical
uniprot
P41594
canonical
ensembl
ENSG00000168959
resolver
ensp
ENSP00000306138
resolver
ensp
ENSP00000405690
resolver
ensp
ENSP00000632283
resolver
genesymbol
GRM5
resolver
genesymbol_syn
GPRC1E
resolver
genesymbol_syn
MGLUR5
resolver
hgnc
HGNC:4597
resolver
uniprot
A8K5P7
resolver
uniprot
Q6J164
resolver
uniprot_entry
A8K5P7_HUMAN
resolver
uniprot_entry
GRM5_HUMAN
resolver
uniprot_sec
Q6J164
resolver
amino_acid_sequence
MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. {ECO:0000269|PubMed:25042998, ECO:0000269|PubMed:7908515}.
uniprot
proteins
mass_dalton
132469
uniprot
proteins
mutagenesis
MUTAGEN 613; /note="S->A,K: Increased constitutive signaling activity."; /evidence="ECO:0000269|PubMed:25042998"; MUTAGEN 614; /note="S->D: Decreased constitutive signaling activity."; /evidence="ECO:0000269|PubMed:25042998"; MUTAGEN 665; /note="K->A: Increased constitutive signaling activity."; /evidence="ECO:0000269|PubMed:25042998"; MUTAGEN 770; /note="E->A: Increased constitutive signaling activity."; /evidence="ECO:0000269|PubMed:25042998
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
19694902
uniprot
proteins
pubmed
25042998
uniprot
proteins
pubmed
28130356
uniprot
proteins
pubmed
7688218
uniprot
proteins
pubmed
7908515
uniprot
proteins
sequence_length
1212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25042998, ECO:0000269|PubMed:7908515}; Multi-pass membrane protein {ECO:0000269|PubMed:25042998, ECO:0000269|PubMed:7908515}.
uniprot
proteins
transmembrane_region
TRANSMEM 581..603; /note="Helical; Name=1"; TRANSMEM 614..636; /note="Helical; Name=2"; TRANSMEM 645..667; /note="Helical; Name=3"; TRANSMEM 694..714; /note="Helical; Name=4"; TRANSMEM 738..759; /note="Helical; Name=5"; TRANSMEM 773..795; /note="Helical; Name=6"; TRANSMEM 799..820; /note="Helical; Name=7
uniprot
proteins