Nup50
entrez
25497
canonical
uniprot
O08587
canonical
ensembl
ENSRNOG00000013423
resolver
ensembl
ENSRNOG00055031253
resolver
ensembl
ENSRNOG00060024991
resolver
ensembl
ENSRNOG00065031841
resolver
ensp
ENSRNOP00000018155
resolver
ensp
ENSRNOP00055044814
resolver
ensp
ENSRNOP00060035882
resolver
ensp
ENSRNOP00065045115
resolver
enst
ENSRNOT00055054178
resolver
enst
ENSRNOT00060043328
resolver
enst
ENSRNOT00065054850
resolver
genesymbol
Nup50
resolver
genesymbol_syn
Npap60
resolver
uniprot
Q4QR93
resolver
uniprot_entry
NUP50_RAT
resolver
uniprot_sec
Q4QR93
resolver
amino_acid_sequence
MAKRVAEKELTDRNWDEEDEVEEMGTFSVASEEVMKNRAVKKAKRRNIGFESDSGGAFKGFKGLVVPSGGGGFSGFGGGSGGKPLEGLTNGNSTDSATPFSSAKTAAEPKAAFGSFAVNGPTTLVDKKISSPKCNSSNQPPSSGPASSTSCTGNTYHKQLAGLNCSVRDWIVKHVNTNPLCDLTPIFKDYERYLATIEKQLENGGSSSSERQTDRATAAMEPPSLFGSTKLQQDSPFSFHGNKAEDTSEKLEFTAEKKSDAAQGATSASFNFGKKIESSVLGSLSSGSLTGFSFSPGNSSLFGKDAAQSKAASSPFSAKASESQAGGSSSECRDGEEEESDEPPKVVVTEVKEEDAFYSKKCKLFYKKDNEFKEKGVGTLHLKPTATQKTQLLVRADTNLGNILLNVLIPPNMPCTRTGKNNVLIVCVPNPPLDEKQPTLPVTMLIRVKTSEDADELHKILLQKKDV
uniprot
proteins
function
FUNCTION: Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with regulatory proteins of cell cycle progression including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B. {ECO:0000250|UniProtKB:Q9JIH2}.
uniprot
proteins
mass_dalton
49818
uniprot
proteins
pubmed
10891499
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9073512
uniprot
proteins
sequence_length
467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:10891499}. Nucleus membrane {ECO:0000269|PubMed:10891499}; Peripheral membrane protein {ECO:0000269|PubMed:10891499}; Nucleoplasmic side {ECO:0000269|PubMed:10891499}. Note=Dissociates from the NPC structure early during prophase of mitosis (By similarity). Associates with the newly formed nuclear membrane during telophase (By similarity). Localizes to the nucleoplasmic fibrils of the nuclear pore complex (PubMed:10891499). In the testis, the localization changes during germ cell differentiation from the nuclear surface in spermatocytes to the whole nucleus (interior) in spermatids and back to the nuclear surface in spermatozoa (PubMed:9073512). {ECO:0000250|UniProtKB:Q9UKX7, ECO:0000269|PubMed:10891499, ECO:0000269|PubMed:9073512}.
uniprot
proteins