Kics2
entrez
270802
canonical
uniprot
Q6P1I3
canonical
ensembl
ENSMUSG00000053684
resolver
ensp
ENSMUSP00000070834
resolver
ensp
ENSMUSP00000117249
resolver
enst
ENSMUST00000136432
resolver
genesymbol
Kics2
resolver
genesymbol_syn
BC048403
resolver
uniprot
D3Z5F2
resolver
uniprot
Q3TE08
resolver
uniprot
Q3TRB8
resolver
uniprot
Q8C334
resolver
uniprot_entry
D3Z5F2_MOUSE
resolver
uniprot_entry
KICS2_MOUSE
resolver
uniprot_sec
Q3TE08
resolver
uniprot_sec
Q3TRB8
resolver
uniprot_sec
Q8C334
resolver
amino_acid_sequence
MGESIPLAAPVPVEQAVLETFFSHLGIFSYDKAKDNVEKEREANKSAGGSWLSLLAALAHLAAAEKVYHSLTYLGQKLGGQSFFSRKDSIRTIYTSLHNELKKVVAGRGAPGGTAPHVEELLPHLSEQLCFFVQARMEIADFYEKMYALSTQKFINTEELVSTLDTILRKYSSRFHHPILSPLESSFQLEVGVLSHLLKAQAQISEWKFLPSLVTLHNAHTKLQSWGQTFEKQRETKKHLFGGQSQKAVQPPHLFLWLMKLKTMLLAKFSFYFHEALSRQTTASEMKALTAKANPDLFGKISSFIRKYDAANVSLIFDNRGSESFQGHGYHHPHSYREAPKGVDQYPAVVSLPSDRPVMHWPNVIMIMTDRASDLNSLEKVVHFYDDKVQSTYFLTRPEPHFTIVVIFESKKSERDSHFISFLNELSLALKNPKVFASLKPGSKG
uniprot
proteins
function
FUNCTION: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. {ECO:0000250|UniProtKB:Q96MD2}.
uniprot
proteins
mass_dalton
50256
uniprot
proteins
protein_family
KICS2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96MD2}.
uniprot
proteins