Mdh2
entrez
81829
canonical
uniprot
P04636
canonical
ensembl
ENSRNOG00000001440
resolver
ensembl
ENSRNOG00055000334
resolver
ensembl
ENSRNOG00060010793
resolver
ensembl
ENSRNOG00065001791
resolver
ensp
ENSRNOP00000001958
resolver
ensp
ENSRNOP00055000450
resolver
ensp
ENSRNOP00060014250
resolver
ensp
ENSRNOP00065001681
resolver
enst
ENSRNOT00000001958
resolver
enst
ENSRNOT00055000587
resolver
enst
ENSRNOT00060018290
resolver
enst
ENSRNOT00065002403
resolver
genesymbol
Mdh2
resolver
genesymbol_syn
Mor1
resolver
uniprot
Q6GSM4
resolver
uniprot_entry
MDHM_RAT
resolver
uniprot_sec
Q6GSM4
resolver
activity_regulation
ACTIVITY REGULATION: Enzyme activity is enhanced by acetylation. {ECO:0000250|UniProtKB:P40926}.
uniprot
proteins
amino_acid_sequence
MLSALARPVGAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETRANVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICIISNPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLATLTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVIECSFVQSKETECTYFSTPLLLGKKGLEKNLGIGKITPFEEKMIAEAIPELKASIKKGEDFVKNMK
uniprot
proteins
ec_number
1.1.1.37
uniprot
proteins
function
FUNCTION: Mitochondrial malate dehydrogenase that catalyzes the reversible conversion of malate to oxaloacetate using NAD(+) as a cofactor. Plays a central role in the tricarboxylic acid (TCA) cycle contributing to cellular respiration and energy production via the mitochondrial electron transport chain (By similarity). Also participates in the malate-aspartate NADH shuttle, facilitating transfer of reducing equivalents between cytosol and mitochondria to maintain redox balance (NAD(+)/NADH homeostasis) and support metabolic flux between compartments (By similarity). In addition to its metabolic role, binds to RNA in cells, associating with cytosolic RNAs including tRNAs and mRNAs (By similarity). {ECO:0000250|UniProtKB:P08249, ECO:0000250|UniProtKB:P40926}.
uniprot
proteins
mass_dalton
35684
uniprot
proteins
post_translational_modification
PTM: Acetylation is enhanced by up to 67% after treatment either with trichostin A (TSA) or with nicotinamide (NAM) with the appearance of tri- and tetraacetylations. Glucose also increases acetylation by about 60%. {ECO:0000250|UniProtKB:P40926}.; PTM: Palmitoylated at Cys-138 by ZDHHC18; palmitoylation increases MDH2 activity and modulates mitochondrial respiration. {ECO:0000250|UniProtKB:P40926}.; PTM: Deacetylation by SIRT3 leads to decreased enzymatic activity and promotes mitochondrial fusion. {ECO:0000250|UniProtKB:P08249}.
uniprot
proteins
protein_family
LDH/MDH superfamily
uniprot
proteins
protein_family
MDH type 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19423663
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24098488
uniprot
proteins
pubmed
3755817
uniprot
proteins
pubmed
3828294
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:24098488}.
uniprot
proteins