SGSM2
entrez
9905
canonical
uniprot
O43147
canonical
ensembl
ENSG00000141258
resolver
ensp
ENSP00000268989
resolver
ensp
ENSP00000415107
resolver
ensp
ENSP00000459126
resolver
ensp
ENSP00000638891
resolver
ensp
ENSP00000684613
resolver
genesymbol
RUTBC1
resolver
genesymbol
SGSM2
resolver
genesymbol_syn
KIAA0397
resolver
genesymbol_syn
RUTBC1
resolver
hgnc
HGNC:29026
resolver
uniprot
A5LGW2
resolver
uniprot
B4DH69
resolver
uniprot
B9A6J3
resolver
uniprot
Q49AC2
resolver
uniprot
Q6ZUY2
resolver
uniprot
Q8IXU4
resolver
uniprot_entry
B9A6J3_HUMAN
resolver
uniprot_entry
SGSM2_HUMAN
resolver
uniprot_sec
A5LGW2
resolver
uniprot_sec
B4DH69
resolver
uniprot_sec
Q49AC2
resolver
uniprot_sec
Q6ZUY2
resolver
uniprot_sec
Q8IXU4
resolver
amino_acid_sequence
MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRIIYPGHRHEHNAGDMIEMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEVVVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAAAYTIELLDTVALNLHRIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIENK
uniprot
proteins
function
FUNCTION: Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:21808068, PubMed:26620560). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560). {ECO:0000269|PubMed:21808068, ECO:0000269|PubMed:26620560}.
uniprot
proteins
mass_dalton
113285
uniprot
proteins
mutagenesis
MUTAGEN 803; /note="R->A: Loss of GTPase activator activity towards RAB32, RAB33B and RAB38."; /evidence="ECO:0000269|PubMed:21808068, ECO:0000269|PubMed:26620560
uniprot
proteins
protein_family
RUTBC family
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17509819
uniprot
proteins
pubmed
21808068
uniprot
proteins
pubmed
26620560
uniprot
proteins
pubmed
9455477
uniprot
proteins
sequence_length
1006
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26620560}. Melanosome {ECO:0000269|PubMed:26620560}. Note=Melanosomal localization is mediated by RAB9A. {ECO:0000269|PubMed:26620560}.
uniprot
proteins