Rhob
entrez
11852
canonical
uniprot
P62746
canonical
ensembl
ENSMUSG00000054364
resolver
ensp
ENSMUSP00000067013
resolver
enst
ENSMUST00000067384
resolver
genesymbol
Rhob
resolver
genesymbol_syn
Arhb
resolver
uniprot
P01121
resolver
uniprot
Q4FJM5
resolver
uniprot
Q9CUV7
resolver
uniprot_entry
Q4FJM5_MOUSE
resolver
uniprot_entry
RHOB_MOUSE
resolver
uniprot_sec
P01121
resolver
uniprot_sec
Q9CUV7
resolver
amino_acid_sequence
MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVANKKDLRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKEGVREVFETATRAALQKRYGSQNGCINCCKVL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells. {ECO:0000269|PubMed:11353846, ECO:0000269|PubMed:11564874, ECO:0000269|PubMed:14597666}.
uniprot
proteins
mass_dalton
22123
uniprot
proteins
post_translational_modification
PTM: Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome (By similarity). {ECO:0000250}.; PTM: Ubiquitinated via 'Lys-63'-linked ubiquitin chains by the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1; leading to targeting RHOB to lysosomes. {ECO:0000250|UniProtKB:P62745}.
uniprot
proteins
protein_family
Rho family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11353846
uniprot
proteins
pubmed
11564874
uniprot
proteins
pubmed
13679852
uniprot
proteins
pubmed
14597666
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15543229
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7559652
uniprot
proteins
pubmed
8662891
uniprot
proteins
pubmed
8831676
uniprot
proteins
sequence_length
196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:14597666}; Lipid-anchor {ECO:0000269|PubMed:14597666}. Cell membrane {ECO:0000269|PubMed:14597666}; Lipid-anchor {ECO:0000269|PubMed:14597666}. Nucleus {ECO:0000269|PubMed:14597666}. Cleavage furrow {ECO:0000250}. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner (By similarity). Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. {ECO:0000250}.
uniprot
proteins