Traip
entrez
22036
canonical
uniprot
Q8VIG6
canonical
ensembl
ENSMUSG00000032586
resolver
ensp
ENSMUSP00000040001
resolver
genesymbol
Traip
resolver
genesymbol_syn
Trip
resolver
uniprot
O08854
resolver
uniprot
Q922M8
resolver
uniprot
Q9CPP4
resolver
uniprot_entry
TRAIP_MOUSE
resolver
uniprot_sec
O08854
resolver
uniprot_sec
Q922M8
resolver
uniprot_sec
Q9CPP4
resolver
amino_acid_sequence
MPIRALCTICSDFFDHSRDVAAIHCGHTFHLQCLIQWFETAPSRTCPQCRIQVGKKTIINKLFFDLAQEEENVLDAEFLKNELDSVKAQLSQKDREKRDSQAIIDTLRDTLEERNATVESLQNALNKAEMLCSTLKKQMKFLEQRQDETKQAREEAHRLKCKMKTMEQIELLLQSQRSEVEEMIRDMGVGQSAVEQLAVYCVSLKKEYENLKEARKATGELADRLKKDLVSSRSKLKTLNTELDQAKLELRSAQKDLQSADQEITSLRKKLMILQGTLSLPPATNETVSRLVFESPAPVEMMNPRLHQPPFGDEIDLNTTFDVNTPPTQTSGSQHCLPKKLCLERARSPMQNVLKKVHKVSKPESQLSLGGQRCVGELDEELAGAFPLFIRNAVLGQKQPNRTTAESRCSTDVVRIGFDGLGGRTKFIQPRDTTIIRPVPVKSKAKSKQKVRIKTVSSASQPKLDTFLCQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase required to protect genome stability in response to replication stress (PubMed:33590678). Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (By similarity). During mitosis, controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex (PubMed:33590678). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (By similarity). Only catalyzes ubiquitination of MCM7 when forks converge (By similarity). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (By similarity). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (By similarity). The function in translesion synthesis is however controversial (By similarity). Acts as a regulator of the spindle assembly checkpoint (By similarity). Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF (PubMed:17544371, PubMed:22945920). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:Q6NRV0, ECO:0000250|UniProtKB:Q9BWF2, ECO:0000269|PubMed:17544371, ECO:0000269|PubMed:22945920, ECO:0000269|PubMed:33590678}.
uniprot
proteins
mass_dalton
53149
uniprot
proteins
mutagenesis
MUTAGEN 7; /note="C->A: Fails to autoubiquitinate."; /evidence="ECO:0000269|PubMed:17544371
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:17544371, ECO:0000269|PubMed:22945920}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000269|PubMed:17544371}.; PTM: Sumoylated; sumoylation is required for nuclear localization. Sumoylation increases protein stability, possibly by preventing ubiquitination. {ECO:0000250|UniProtKB:Q9BWF2}.
uniprot
proteins
protein_family
TRAIP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17544371
uniprot
proteins
pubmed
17927961
uniprot
proteins
pubmed
22945920
uniprot
proteins
pubmed
27405720
uniprot
proteins
pubmed
33590678
uniprot
proteins
pubmed
9104814
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9BWF2}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9BWF2}. Chromosome {ECO:0000269|PubMed:27405720, ECO:0000269|PubMed:33590678}. Cytoplasm {ECO:0000250|UniProtKB:Q9BWF2}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9BWF2}. Note=In the nucleus, found in close proximity to PCNA, suggesting localization at replication foci (PubMed:33590678). Localizes to DNA damage sites in response to replication stress (By similarity). {ECO:0000250|UniProtKB:Q9BWF2, ECO:0000269|PubMed:33590678}.
uniprot
proteins