LRRC19
entrez
64922
canonical
uniprot
Q9H756
canonical
ensembl
ENSG00000184434
resolver
ensp
ENSP00000369395
resolver
ensp
ENSP00000573417
resolver
ensp
ENSP00000573418
resolver
enst
ENST00000380055
resolver
enst
ENST00000903358
resolver
enst
ENST00000903359
resolver
genesymbol
LRRC19
resolver
hgnc
HGNC:23379
resolver
uniprot
A0AV00
resolver
uniprot
B9EG91
resolver
uniprot_entry
LRC19_HUMAN
resolver
uniprot_sec
A0AV00
resolver
uniprot_sec
B9EG91
resolver
activity_regulation
ACTIVITY REGULATION: Activated by TLR ligands such as LPS, bacterial DNA and peptidoglycan. {ECO:0000250|UniProtKB:Q8BZT5}.
uniprot
proteins
amino_acid_sequence
MKVTGITILFWPLSMILLSDKIQSSKREVQCNFTEKNYTLIPADIKKDVTILDLSYNQITLNGTDTRVLQTYFLLTELYLIENKVTILHNNGFGNLSSLEILNICRNSIYVIQQGAFLGLNKLKQLYLCQNKIEQLNADVFVPLRSLKLLNLQGNLISYLDVPPLFHLELITLYGNLWNCSCSLFNLQNWLNTSNVTLENENITMCSYPNSLQSYNIKTVPHKAECHSKFPSSVTEDLYIHFQPISNSIFNSSSNNLTRNSEHEPLGKSWAFLVGVVVTVLTTSLLIFIAIKCPIWYNILLSYNHHRLEEHEAETYEDGFTGNPSSLSQIPETNSEETTVIFEQLHSFVVDDDGFIEDKYIDIHELCEEN
uniprot
proteins
function
FUNCTION: Pathogen-recognition receptor which mediates the activation of TRAF2- and TRAF6 NF-kappa-B signaling pathways and induces the expression of pro-inflammatory cytokines (PubMed:19679103, PubMed:25026888). In kidney, prevents infection by uropathogenic bacteria by inducing the production of cytokines, chemokines and antimicrobial substances. In gut, involved in host-microbiota interactions, plays a critical role in promoting the recruitment of immune cells and intestinal inflammation (By similarity). {ECO:0000250|UniProtKB:Q8BZT5, ECO:0000269|PubMed:19679103, ECO:0000269|PubMed:25026888}.
uniprot
proteins
mass_dalton
42334
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19679103
uniprot
proteins
pubmed
25026888
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 271..291; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins