CLDN3
entrez
1365
canonical
uniprot
O15551
canonical
ensembl
ENSG00000165215
resolver
ensp
ENSP00000378577
resolver
enst
ENST00000395145
resolver
genesymbol
CLDN3
resolver
genesymbol_syn
C7orf1
resolver
genesymbol_syn
CPETR2
resolver
hgnc
HGNC:2045
resolver
uniprot
Q75L79
resolver
uniprot_entry
CLD3_HUMAN
resolver
uniprot_entry
Q75L79_HUMAN
resolver
amino_acid_sequence
MSMGLEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDDTAKAKITIVAGVLFLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALLCCSCPPREKKYTATKVVYSAPRSTGPGASLGTGYDRKDYV
uniprot
proteins
disease_involvement
DISEASE: Note=CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
uniprot
proteins
function
FUNCTION: Barrier-forming claudin. Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000269|PubMed:36008380}.
uniprot
proteins
mass_dalton
23319
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28028216
uniprot
proteins
pubmed
30734065
uniprot
proteins
pubmed
36008380
uniprot
proteins
pubmed
9334247
uniprot
proteins
pubmed
9441748
uniprot
proteins
sequence_length
220
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:28028216, ECO:0000269|PubMed:30734065}. Cell membrane {ECO:0000269|PubMed:28028216}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 81..101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins