Gad2
entrez
24380
canonical
uniprot
Q05683
canonical
ensembl
ENSRNOG00000017803
resolver
ensembl
ENSRNOG00055001178
resolver
ensembl
ENSRNOG00060016275
resolver
ensembl
ENSRNOG00065003157
resolver
ensp
ENSRNOP00000099178
resolver
ensp
ENSRNOP00055001533
resolver
ensp
ENSRNOP00060022394
resolver
ensp
ENSRNOP00065003170
resolver
enst
ENSRNOT00000153818
resolver
enst
ENSRNOT00055001955
resolver
enst
ENSRNOT00060027867
resolver
enst
ENSRNOT00065004444
resolver
genesymbol
Gad2
resolver
genesymbol_syn
Gad65
resolver
uniprot_entry
DCE2_RAT
resolver
amino_acid_sequence
MASPGSGFWSFGSEDGSGDPENPGTARAWCQVAQKFTGGIGNKLCALLYGDSEKPAESGGSVTSRAATRKVACTCDQKPCSCPKGDVNYALLHATDLLPACEGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILTHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMLIARYKMFPEVKEKGMAAVPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEVKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLNGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQSCNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHIDKCLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWFVPPSLRVLEDNEERMSRLSKVAPVIKARMMEYGTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL
uniprot
proteins
ec_number
4.1.1.15
uniprot
proteins
function
FUNCTION: Catalyzes the production of GABA. {ECO:0000305|PubMed:8999827}.
uniprot
proteins
mass_dalton
65402
uniprot
proteins
mutagenesis
MUTAGEN 10..17; /note="SFGSEDGS->AFGAEDGA: No effect on glutamate decarboxylase activity."; /evidence="ECO:0000269|PubMed:8999827"; MUTAGEN 30; /note="C->A: Abolishes palmitoylation but not membrane-association; when associated with A-45. No effect on glutamate decarboxylase activity; when associated with A-45."; /evidence="ECO:0000269|PubMed:8132714, ECO:0000269|PubMed:8999827"; MUTAGEN 45; /note="C->A: Abolishes palmitoylation but not membrane-association; when associated with A-30. No effect on glutamate decarboxylase activity; when associated with A-30."; /evidence="ECO:0000269|PubMed:8132714, ECO:0000269|PubMed:8999827"; MUTAGEN 73; /note="C->S: No effect on palmitoylation."; /evidence="ECO:0000269|PubMed:8132714"; MUTAGEN 75; /note="C->S: No effect on palmitoylation."; /evidence="ECO:0000269|PubMed:8132714"; MUTAGEN 80; /note="C->S: No effect on palmitoylation."; /evidence="ECO:0000269|PubMed:8132714"; MUTAGEN 82; /note="C->S: No effect on palmitoylation."; /evidence="ECO:0000269|PubMed:8132714"; MUTAGEN 101; /note="C->S: No effect on palmitoylation."; /evidence="ECO:0000269|PubMed:8132714
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.; PTM: Phosphorylated; which does not affect kinetic parameters or subcellular location. {ECO:0000269|PubMed:8999827}.; PTM: Palmitoylated; which is required for presynaptic clustering. {ECO:0000250}.
uniprot
proteins
protein_family
Group II decarboxylase family
uniprot
proteins
pubmed
1321158
uniprot
proteins
pubmed
2069816
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
3385490
uniprot
proteins
pubmed
8132714
uniprot
proteins
pubmed
8999827
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:8999827}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q05329}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q05329}; Lipid-anchor {ECO:0000250|UniProtKB:Q05329}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q05329}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q05329}; Cytoplasmic side {ECO:0000250|UniProtKB:Q05329}. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters. {ECO:0000250|UniProtKB:Q05329}.
uniprot
proteins