Ephb4
entrez
13846
canonical
uniprot
P54761
canonical
ensembl
ENSMUSG00000029710
resolver
ensp
ENSMUSP00000051622
resolver
ensp
ENSMUSP00000106684
resolver
ensp
ENSMUSP00000115731
resolver
ensp
ENSMUSP00000130275
resolver
enst
ENSMUST00000061244
resolver
enst
ENSMUST00000111055
resolver
enst
ENSMUST00000144296
resolver
enst
ENSMUST00000166239
resolver
genesymbol
Ephb4
resolver
genesymbol_syn
Htk
resolver
genesymbol_syn
Mdk2
resolver
genesymbol_syn
Myk1
resolver
uniprot
F6XQU0
resolver
uniprot
Q3V1K8
resolver
uniprot
Q60627
resolver
uniprot
Q8C7S3
resolver
uniprot
Q8C8K1
resolver
uniprot
Q99MR2
resolver
uniprot_entry
EPHB4_MOUSE
resolver
uniprot_entry
F6XQU0_MOUSE
resolver
uniprot_entry
Q3V1K8_MOUSE
resolver
uniprot_entry
Q8C7S3_MOUSE
resolver
uniprot_entry
Q8C8K1_MOUSE
resolver
uniprot_sec
Q60627
resolver
uniprot_sec
Q99MR2
resolver
amino_acid_sequence
MELRALLCWASLATALEETLLNTKLETADLKWVTYPQAEGQWEELSGLDEEQHSVRTYEVCDMKRPGGQAHWLRTGWVPRRGAVHVYATIRFTMMECLSLPRASRSCKETFTVFYYESEADTATAHTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNIKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCSWLITNLTYFPETVPRELVVPVAGSCVANAVPTANPSPSLYCREDGQWAEQQVTGCSCAPGYEAAESNKVCRACGQGTFKPQIGDESCLPCPANSHSNNIGSPVCLCRIGYYRARSDPRSSPCTTPPSAPRSVVHHLNGSTLRLEWSAPLESGGREDLTYAVRCRECRPGGSCLPCGGDMTFDPGPRDLVEPWVAIRGLRPDVTYTFEVAALNGVSTLATGPPPFEPVNVTTDREVPPAVSDIRVTRSSPSSLILSWAIPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESESWREQLALIAGTAVVGVVLVLVVVIIAVLCLRKQSNGREVEYSDKHGQYLIGHGTKVYIDPFTYEDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLLDQRQPHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFEVVSQISAEDLLRIGVTLAGHQKKILASVQHMKSQAKPGAPGGTGGPAQQF
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which binds promiscuously to transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2, it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells (PubMed:10518221). Phosphorylates inactive tyrosine-protein kinase EPHB6 which promotes interaction of EPHB6 with SH2 domains, allowing it to recruit SH2 domain-containing signaling adapters (By similarity). {ECO:0000250|UniProtKB:P54760, ECO:0000269|PubMed:10518221}.
uniprot
proteins
mass_dalton
108848
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; autophosphorylation is stimulated by EFNB2. {ECO:0000250}.
uniprot
proteins
protein_family
Ephrin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10518221
uniprot
proteins
pubmed
11239002
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27400125
uniprot
proteins
pubmed
27446912
uniprot
proteins
pubmed
7478528
uniprot
proteins
pubmed
8152808
uniprot
proteins
sequence_length
987
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P54760}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P54760}.
uniprot
proteins
transmembrane_region
TRANSMEM 540..560; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins