AQP9
entrez
366
canonical
uniprot
O43315
canonical
ensembl
ENSG00000103569
resolver
ensp
ENSP00000219919
resolver
ensp
ENSP00000452673
resolver
ensp
ENSP00000791153
resolver
enst
ENST00000219919
resolver
enst
ENST00000558772
resolver
genesymbol
AQP9
resolver
genesymbol_syn
SSC1
resolver
hgnc
HGNC:643
resolver
uniprot
H0YK62
resolver
uniprot
Q9NP32
resolver
uniprot_entry
AQP9_HUMAN
resolver
uniprot_entry
H0YK62_HUMAN
resolver
uniprot_sec
Q9NP32
resolver
amino_acid_sequence
MQPEGAEKGKSFKQRLVLKSSLAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGKLLIVGENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSRNLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFRAGNNFWWIPVVGPLVGAVIGGLIYVLVIEIHHPEPDSVFKTEQSEDKPEKYELSVIM
uniprot
proteins
function
FUNCTION: Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:10564231, PubMed:30420639, PubMed:35054513, PubMed:9514918). AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis (By similarity). It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines (PubMed:10564231). AQP9 may also facilitate hepatic urea extrusion (PubMed:10564231, PubMed:9514918). Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy (PubMed:10564231, PubMed:35054513). Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity (PubMed:10564231). It is also permeable to H2O2 in vivo (PubMed:26837049). Could also be permeable to ammonium (By similarity). {ECO:0000250|UniProtKB:P56627, ECO:0000250|UniProtKB:Q9JJJ3, ECO:0000269|PubMed:10564231, ECO:0000269|PubMed:26837049, ECO:0000269|PubMed:30420639, ECO:0000269|PubMed:35054513, ECO:0000269|PubMed:9514918}.
uniprot
proteins
mass_dalton
31431
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
10564231
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
26837049
uniprot
proteins
pubmed
30420639
uniprot
proteins
pubmed
35054513
uniprot
proteins
pubmed
9514918
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10564231, ECO:0000269|PubMed:9514918}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96PS8}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9JJJ3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96PS8}. Note=Functions at the hepatocyte basolateral membrane. {ECO:0000250|UniProtKB:Q9JJJ3}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..43; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q96PS8"; TRANSMEM 58..77; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q96PS8"; TRANSMEM 99..123; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q96PS8"; TRANSMEM 161..178; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q96PS8"; TRANSMEM 191..207; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q96PS8"; TRANSMEM 244..264; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q96PS8
uniprot
proteins