Trpv6
entrez
114246
canonical
uniprot
Q9R186
canonical
ensembl
ENSRNOG00000014714
resolver
ensp
ENSRNOP00000020616
resolver
genesymbol
Trpv6
resolver
genesymbol_syn
TRPV6
resolver
uniprot
B6ZDS2
resolver
uniprot_entry
B6ZDS2_RAT
resolver
uniprot_entry
TRPV6_RAT
resolver
amino_acid_sequence
MGPLQREGRPALGDANVAPGSSPGGVWHQPQPPKDSAFHPMGWSLPKEKGLILCLWNKFCRWFHRRESWAQSRDEQNLLQQKRIWESPLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQKRKHIQWTYGPLTSTLYDLTEIDSSGDDQSLLELIVTTKKREARQILDQTPVKELVSLKWKRYGRPYFCVLGAIYVLYIICFTMCCVYRPLKPRITNRTNPRDNTLLQQKLLQEAYVTPKDDLRLVGELVSIVGAVIILLVEIPDIFRLGVTRFFGQTILGGPFHVIIVTYAFMVLVTMVMRLTNSDGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPDELGHFYDYPMALFSTFELFLTIIDGPANYDVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQVVATTVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIRRYAQAFQQQDDLYSEDLEKDSGEKLEMARPFGAYLSFPTPSVSRSTSRSSTNWDRLRQGALRKDLQGIINRGLEDGEGWEYQI
uniprot
proteins
function
FUNCTION: Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:10428857, PubMed:11287959, PubMed:27296226, PubMed:28878326). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:10428857, PubMed:11287959, PubMed:27296226). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250|UniProtKB:Q91WD2, ECO:0000250|UniProtKB:Q9H1D0, ECO:0000269|PubMed:10428857, ECO:0000269|PubMed:11287959, ECO:0000269|PubMed:27296226, ECO:0000269|PubMed:28878326}.
uniprot
proteins
mass_dalton
87362
uniprot
proteins
mutagenesis
MUTAGEN 201; /note="Y->F: Prevents up-regulation of the channel by phosphorylation; when associated with F-202."; /evidence="ECO:0000269|PubMed:17197020"; MUTAGEN 202; /note="Y->F: Prevents up-regulation of the channel by phosphorylation; when associated with F-201."; /evidence="ECO:0000269|PubMed:17197020"; MUTAGEN 535; /note="L->Q: Alters subunit assembly via domain swapping and reduces channel activity."; /evidence="ECO:0000269|PubMed:28878326
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q91WD2, ECO:0000250|UniProtKB:Q9H1D0}.; PTM: Phosphorylation at Tyr-201 and Tyr-202 by SRC leads to an increased calcium influx through the channel. Probably dephosphorylated at these sites by PTPN1. {ECO:0000269|PubMed:17197020}.
uniprot
proteins
protein_family
TRPV6 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
protein_family
TrpV subfamily
uniprot
proteins
pubmed
10428857
uniprot
proteins
pubmed
11287959
uniprot
proteins
pubmed
17197020
uniprot
proteins
pubmed
27296226
uniprot
proteins
pubmed
28878326
uniprot
proteins
pubmed
29258289
uniprot
proteins
sequence_length
767
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10428857, ECO:0000269|PubMed:17197020, ECO:0000269|PubMed:27296226, ECO:0000269|PubMed:28878326, ECO:0000269|PubMed:29258289}; Multi-pass membrane protein {ECO:0000269|PubMed:27296226, ECO:0000269|PubMed:28878326, ECO:0000269|PubMed:29258289}.
uniprot
proteins
transmembrane_region
TRANSMEM 367..387; /note="Helical"; /evidence="ECO:0000269|PubMed:27296226, ECO:0000269|PubMed:28878326"; TRANSMEM 425..447; /note="Helical"; /evidence="ECO:0000269|PubMed:27296226, ECO:0000269|PubMed:28878326"; TRANSMEM 463..482; /note="Helical"; /evidence="ECO:0000269|PubMed:27296226, ECO:0000269|PubMed:28878326"; TRANSMEM 489..508; /note="Helical"; /evidence="ECO:0000269|PubMed:27296226, ECO:0000269|PubMed:28878326"; TRANSMEM 529..551; /note="Helical"; /evidence="ECO:0000269|PubMed:27296226, ECO:0000269|PubMed:28878326"; TRANSMEM 596..616; /note="Helical"; /evidence="ECO:0000269|PubMed:27296226, ECO:0000269|PubMed:28878326
uniprot
proteins