PDCD10
entrez
11235
canonical
uniprot
Q9BUL8
canonical
ensembl
ENSG00000114209
resolver
ensp
ENSP00000376506
resolver
ensp
ENSP00000417118
resolver
ensp
ENSP00000417202
resolver
ensp
ENSP00000418317
resolver
ensp
ENSP00000420021
resolver
ensp
ENSP00000420553
resolver
ensp
ENSP00000547711
resolver
ensp
ENSP00000547712
resolver
ensp
ENSP00000547713
resolver
ensp
ENSP00000547714
resolver
ensp
ENSP00000547715
resolver
ensp
ENSP00000547716
resolver
ensp
ENSP00000547717
resolver
ensp
ENSP00000547718
resolver
ensp
ENSP00000547719
resolver
ensp
ENSP00000547720
resolver
ensp
ENSP00000547721
resolver
ensp
ENSP00000547722
resolver
ensp
ENSP00000547723
resolver
ensp
ENSP00000547724
resolver
ensp
ENSP00000547725
resolver
ensp
ENSP00000547726
resolver
ensp
ENSP00000547728
resolver
ensp
ENSP00000547729
resolver
ensp
ENSP00000547730
resolver
ensp
ENSP00000605552
resolver
ensp
ENSP00000605553
resolver
ensp
ENSP00000605555
resolver
ensp
ENSP00000605556
resolver
ensp
ENSP00000605557
resolver
ensp
ENSP00000605558
resolver
ensp
ENSP00000626461
resolver
ensp
ENSP00000626462
resolver
ensp
ENSP00000626463
resolver
enst
ENST00000392750
resolver
enst
ENST00000461494
resolver
enst
ENST00000470131
resolver
enst
ENST00000473645
resolver
enst
ENST00000497056
resolver
enst
ENST00000877652
resolver
enst
ENST00000877653
resolver
enst
ENST00000877654
resolver
enst
ENST00000877655
resolver
enst
ENST00000877656
resolver
enst
ENST00000877657
resolver
enst
ENST00000877658
resolver
enst
ENST00000877659
resolver
enst
ENST00000877660
resolver
enst
ENST00000877661
resolver
enst
ENST00000877662
resolver
enst
ENST00000877663
resolver
enst
ENST00000877664
resolver
enst
ENST00000877665
resolver
enst
ENST00000877666
resolver
enst
ENST00000877667
resolver
enst
ENST00000877669
resolver
enst
ENST00000877670
resolver
enst
ENST00000877671
resolver
enst
ENST00000935493
resolver
enst
ENST00000935494
resolver
enst
ENST00000935496
resolver
enst
ENST00000935497
resolver
enst
ENST00000935498
resolver
enst
ENST00000935499
resolver
enst
ENST00000956402
resolver
enst
ENST00000956403
resolver
enst
ENST00000956404
resolver
genesymbol
PDCD10
resolver
genesymbol_syn
CCM3
resolver
genesymbol_syn
TFAR15
resolver
hgnc
HGNC:8761
resolver
uniprot
A8K515
resolver
uniprot
D3DNN5
resolver
uniprot
O14811
resolver
uniprot_entry
PDC10_HUMAN
resolver
uniprot_sec
A8K515
resolver
uniprot_sec
D3DNN5
resolver
uniprot_sec
O14811
resolver
amino_acid_sequence
MRMTMEEMKNEAETTSMVSMPLYAVMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIIMKILEKKSVEVNFTESLLRMAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELLDTVNNVFKKYQYQNRRALEHQKKEFVKYSKSFSDTLKTYFKDGKAINVFVSANRLIHQTNLILQTFKTVA
uniprot
proteins
disease_involvement
DISEASE: Cerebral cavernous malformations 3 (CCM3) [MIM:603285]: A form of cerebral cavernous malformations, a congenital vascular anomaly of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters. CCM3 inheritance is autosomal dominant. {ECO:0000269|PubMed:15543491}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). {ECO:0000250|UniProtKB:Q8VE70, ECO:0000269|PubMed:15543491, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:20332113, ECO:0000269|PubMed:27807006}.
uniprot
proteins
mass_dalton
24702
uniprot
proteins
mutagenesis
MUTAGEN 132; /note="K->D: Loss of interaction with CCM2 and PXN; when associated with D-139; D-172 and D-179."; /evidence="ECO:0000269|PubMed:20489202"; MUTAGEN 135; /note="A->D: Loss of interaction with CCM2."; /evidence="ECO:0000269|PubMed:20489202"; MUTAGEN 139; /note="K->D: Loss of interaction with CCM2 and PXN; when associated with D-132; D-172 and D-179."; /evidence="ECO:0000269|PubMed:20489202"; MUTAGEN 172; /note="K->D: Loss of interaction with CCM2 and PXN; when associated with D-132; D-139 and D-179."; /evidence="ECO:0000269|PubMed:20489202"; MUTAGEN 175; /note="S->D: Loss of interaction with CCM2."; /evidence="ECO:0000269|PubMed:20489202"; MUTAGEN 179; /note="K->D: Loss of interaction with CCM2 and PXN; when associated with D-132; D-139 and D-172."; /evidence="ECO:0000269|PubMed:20489202
uniprot
proteins
protein_family
PDCD10 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15543491
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17360971
uniprot
proteins
pubmed
18782753
uniprot
proteins
pubmed
19370760
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20332113
uniprot
proteins
pubmed
20489202
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27807006
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
38517886
uniprot
proteins
sequence_length
212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:18782753}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q6NX65}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NX65}; Cytoplasmic side {ECO:0000250|UniProtKB:Q6NX65}. Cell membrane {ECO:0000250|UniProtKB:Q6NX65}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NX65}; Cytoplasmic side {ECO:0000250|UniProtKB:Q6NX65}.
uniprot
proteins