Dtx3l
entrez
209200
canonical
uniprot
Q3UIR3
canonical
ensembl
ENSMUSG00000049502
resolver
ensp
ENSMUSP00000080601
resolver
genesymbol
Dtx3l
resolver
genesymbol_syn
Bbap
resolver
uniprot
Q8BN11
resolver
uniprot_entry
DTX3L_MOUSE
resolver
uniprot_sec
Q8BN11
resolver
activity_regulation
ACTIVITY REGULATION: Binding to PARP9 enhances DTX3L catalytic activity. {ECO:0000250|UniProtKB:Q8TDB6}.
uniprot
proteins
amino_acid_sequence
MASSPDPPSPLLVRLRESIPKAHRKLEIYFQSRASGGGECSVQPVGPSAPDTYEVKFLKKADKEKVLKKSEHEMLVHNKPVTIVLETTKKPVEDLRPRLPSLTQPVETPSSRPPSLTGSLDEALCDDIHPQDGLVSNSVDSVVQKIFLAVTAELNCDLLSKEQRASITTVCPHIIKSMEGSDGIKKVCGNFKDIEKIHHFLSEQLLEREQKRKGSEQKRKCAPQKHTPPDVEREPPDQSSIQVPVLLLEYFKHVNPGRLEFIEYKFGVNIEIQASSPNMVTVGFTSSPFGNVEEASQSFVRDFQKCSQSLKQDCISLEEHQRAKEVRQELSRCFPKLLIKGQGRTLTLLGSPADISAATEKVSQGLGLRPVKITASGYTTGIEVDSTRFKLLEPELLQEISEIEQKFNTRGKVQEKGQKTCILFVPKDKDLDLSVQSYTGFTDAFQRATWQLRTEVLSLKGLGKERARLHNTKFADNFKKEHPNVHFVTSQESVTLTGLPHHLAQAMQYVSKRMGLAPSSGEKLAMDQETPMEISSSDPHGDQQENAALPAPRGTSSSPAASKGTEDYCVICMDTISNKHVLPKCKHEFCTSCISKAMLIKPVCPVCLTSYGIQKGNQPEGTMSYSTQKGSLPGYEGCGTIVINYEIKDGIQTKEHPNPGKAYHGTRRTAYLPDNTEGRKVLDLLHEAFKHRLTFTIGYSRATGVSDVITWNDIHHKTSKFGGPANFGYPDPDYLKRVKEELKAKGIE
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses. Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4. In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication. Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM. In addition, required for the recruitment of HGS and STAM to early endosomes. {ECO:0000250|UniProtKB:Q8TDB6}.
uniprot
proteins
mass_dalton
83044
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8TDB6}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000250|UniProtKB:Q8TDB6}.
uniprot
proteins
protein_family
Deltex family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18069692
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
748
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TDB6}. Nucleus {ECO:0000250|UniProtKB:Q8TDB6}. Early endosome membrane {ECO:0000250|UniProtKB:Q8TDB6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8TDB6}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8TDB6}. Lysosome membrane {ECO:0000250|UniProtKB:Q8TDB6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8TDB6}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8TDB6}. Note=Translocates to the nucleus in response to IFNG or IFNB1 stimulation. Localizes at sites of DNA damage in a PARP1-dependent manner. Localization to early endosomes is increased upon CXCL12 stimulation where it co-localizes with ITCH, CXCL4, HGS and STAM. A minor proportion localizes to lysosomes. {ECO:0000250|UniProtKB:Q8TDB6}.
uniprot
proteins