Soat1
entrez
20652
canonical
uniprot
Q61263
canonical
ensembl
ENSMUSG00000026600
resolver
ensp
ENSMUSP00000058344
resolver
ensp
ENSMUSP00000140721
resolver
enst
ENSMUST00000051396
resolver
enst
ENSMUST00000189661
resolver
genesymbol
Soat1
resolver
genesymbol_syn
Acact
resolver
uniprot
Q5XK32
resolver
uniprot
Q64180
resolver
uniprot_entry
SOAT1_MOUSE
resolver
uniprot_sec
Q5XK32
resolver
uniprot_sec
Q64180
resolver
amino_acid_sequence
MSLRNRLSKSGENPEQDEAQKNFMDTYRNGHITMKQLIAKKRLLAAEAEELKPLFMKEVGCHFDDFVTNLIEKSASLDNGGCALTTFSILEEMKKNHRAKDLRAPPEQGKIFISRQSLLDELFEVDHIRTIYHMFIALLILFVLSTIVVDYIDEGRLVLEFNLLAYAFGKFPTVIWTWWAMFLSTLSIPYFLFQRWAHGYSKSSHPLIYSLVHGLLFLVFQLGVLGFVPTYVVLAYTLPPASRFILILEQIRLIMKAHSFVRENIPRVLNAAKEKSSKDPLPTVNQYLYFLFAPTLIYRDNYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFKSAAMLAVFALSAVVHEYALAICLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPIWNIMVWASLFLGYGLILCFYSQEWYARQHCPLKNPTFLDYVRPRTWTCRYVF
uniprot
proteins
ec_number
2.3.1.26
uniprot
proteins
function
FUNCTION: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Preferentially utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) as a substrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions. {ECO:0000250|UniProtKB:P35610}.
uniprot
proteins
mass_dalton
63799
uniprot
proteins
protein_family
Membrane-bound acyltransferase family
uniprot
proteins
protein_family
Sterol o-acyltransferase subfamily
uniprot
proteins
pubmed
11071899
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7592824
uniprot
proteins
pubmed
8579615
uniprot
proteins
sequence_length
540
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11071899}; Multi-pass membrane protein {ECO:0000269|PubMed:11071899}.
uniprot
proteins
transmembrane_region
TRANSMEM 129..150; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 171..196; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 209..234; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 243..266; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 310..342; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 360..385; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 434..458; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 465..480; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 487..518; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P35610
uniprot
proteins