RAB5C
entrez
5878
canonical
uniprot
P51148
canonical
ensembl
ENSG00000108774
resolver
ensp
ENSP00000345689
resolver
ensp
ENSP00000447053
resolver
ensp
ENSP00000579901
resolver
genesymbol
RAB5C
resolver
genesymbol_syn
RABL
resolver
hgnc
HGNC:9785
resolver
uniprot
F8W1H5
resolver
uniprot
Q6FH55
resolver
uniprot
Q9P0Y5
resolver
uniprot_entry
RAB5C_HUMAN
resolver
uniprot_sec
F8W1H5
resolver
uniprot_sec
Q6FH55
resolver
uniprot_sec
Q9P0Y5
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP (Probable). Regulated by GTPase activating proteins (GAPs) including SGSM3, which increase the GTP hydrolysis activity (PubMed:16086013, PubMed:17562788). Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000269|PubMed:16086013, ECO:0000269|PubMed:17562788, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MAGRGGAARPNGPAAGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNTDTFARAKNWVKELQRQASPNIVIALAGNKADLASKRAVEFQEAQAYADDNSLLFMETSAKTAMNVNEIFMAIAKKLPKNEPQNATGAPGRNRGVDLQENNPASRSQCCSN
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:16086013, PubMed:17562788). Involved in early endocytic trafficking (PubMed:16086013, PubMed:17562788). Required for EEA1 recruitment to early endosomes (PubMed:16086013, PubMed:17562788). Required for EGF and transferrin endocytosis and trafficking through early endosomes (PubMed:16086013, PubMed:17562788). {ECO:0000269|PubMed:16086013, ECO:0000269|PubMed:17562788}.
uniprot
proteins
mass_dalton
23483
uniprot
proteins
mutagenesis
MUTAGEN 85; /note="S->A: Loss of phosphorylation. No effect on GDI1, GDI2, CHML and CHM binding."; /evidence="ECO:0000269|PubMed:29125462"; MUTAGEN 85; /note="S->E: Phosphomimetic mutant. Loss of GDI1, GDI2, CHML and CHM binding."; /evidence="ECO:0000269|PubMed:29125462
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-85 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2. {ECO:0000269|PubMed:29125462}.; PTM: (Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3. {ECO:0000269|PubMed:32974215}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10768959
uniprot
proteins
pubmed
12493736
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16086013
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
17562788
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21750715
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29125462
uniprot
proteins
pubmed
32974215
uniprot
proteins
pubmed
7951316
uniprot
proteins
pubmed
8646882
uniprot
proteins
sequence_length
216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20339}; Lipid-anchor {ECO:0000250|UniProtKB:P20339}; Cytoplasmic side {ECO:0000250|UniProtKB:P20339}. Early endosome membrane {ECO:0000250|UniProtKB:P20339}; Lipid-anchor {ECO:0000250|UniProtKB:P20339}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.
uniprot
proteins