Amer2
entrez
72125
canonical
uniprot
Q8CCJ4
canonical
ensembl
ENSMUSG00000021986
resolver
ensp
ENSMUSP00000022561
resolver
ensp
ENSMUSP00000153031
resolver
ensp
ENSMUSP00000159188
resolver
enst
ENSMUST00000239079
resolver
genesymbol
Amer2
resolver
genesymbol_syn
Fam123a
resolver
uniprot
A0A0R4J030
resolver
uniprot
Q7TNC5
resolver
uniprot
Q8K0U9
resolver
uniprot
Q9D0Q2
resolver
uniprot_entry
A0A0R4J030_MOUSE
resolver
uniprot_entry
AMER2_MOUSE
resolver
uniprot_sec
Q7TNC5
resolver
uniprot_sec
Q8K0U9
resolver
uniprot_sec
Q9D0Q2
resolver
amino_acid_sequence
METGRSRGGGAAVSERGGGARAGVCGRQEQAGALAADMDSHCECAAETPAAEPPSGKINKAAFKLFKKRKSGGTMPSIFGVKNKGDGKSSGPTGMVRSRTHDGLAEVLVLEGSKKEEPPGGSDHSGARPIPGPPKPSGPGLGSLASSSVAKSHSFFSLLKKNGRSETGKGDHAEASKAGGKQKRGLKGIFSSMRWHRRDKRGKEEEEKAVRAAGPGNLVLPGSLTASLECVKEEPPRAARRPDSPGQDASRHAAGEPAGGEQAPASAESAPERICLEAGSPTGSGDQSSRGEDAEGHRREEKPGAALESGAGEVQAAEDASKTGDVPIKTVPLVDSEGGSGRASAVPDPSSVDPPSDPSADRICLMFSDVTSLKSFDSLTGCGDIIADPEEEAGPSCDKHVPGPGKPVLSKKNASVVAYQGGGEEMASPDQVDDTYLPEFWDMLSQTEDQGQGTQEGAAKAATASDIKLAPETSSDTRCGEAAKDMSSVKRRRLHRIPIESQQKEEPKHPEKEHQEGVPNSDEGYWDSTTPGPEEESISNSSSSKKVVIPRDSDSGDALCDLYVEPEASPATLPATEDPPCLSRLKPVSPGTITCPLRTPGSLLKDSKIPISIKHLSNLPSSHPVVHQQPARSEVPRTKIPVSKVLVRRVSNRGLAGTTIRAAACHDSAKKL
uniprot
proteins
function
FUNCTION: Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
69933
uniprot
proteins
protein_family
Amer family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
672
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2. {ECO:0000250}.
uniprot
proteins