Q02294
uniprot
Q02294
canonical
activity_regulation
ACTIVITY REGULATION: Is specifically blocked by omega-conotoxin GVIA (Probable) (PubMed:10938268). Is specifically blocked by omega-conotoxin MVIIA (ziconotide) (By similarity). Is insensitive to dihydropyridines (DHP). {ECO:0000250|UniProtKB:Q00975, ECO:0000269|PubMed:10938268, ECO:0000305|PubMed:1317580}.
uniprot
proteins
amino_acid_sequence
MVRFGDELGGRYGGTGGGERARGGGAGGAGGPGQGGLPPGQRVLYKQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTEILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCDSDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDAVLKRAATKKSRNDLIHAEEGEDRFVDLCAAGSPFARASLKSGKTESSSYFRRKEKMFRFLIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRYASTRHVRPDMKTHMDRPLVVEPGRDGLRGPAGNKSKPEGTEATEGADPPRRHHRHRDRDKTSASTPAGGEQDRTDCPKAESTETGAREERARPRRSHSKEAPGADTQVRCERSRRHHRRGSPEEATEREPRRHRAHRHAQDSSKEGKEGTAPVLVPKGERRARHRGPRTGPRETENSEEPTRRHRAKHKVPPTLEPPEREVAEKESNVVEGDKETRNHQPKEPRCDLEAIAVTGVGSLHMLPSTCLQKVDEQPEDADNQRNVTRMGSQPSDPSTTVHVPVTLTGPPGEATVVPSANTDLEGQAEGKKEAEADDVLRRGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDSFRNNALKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFMGGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSLECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSFLRLFRAARLIKLCRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDGTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGNRACDPHANASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISSVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQTHQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSATSLSNGGAIQTQESGIKESLSWGTQRTQDVLYEARAPLERGHSAEIPVGQPGALAVDVQMQNMTLRGPDGEPQPGLESQGRAASMPRLAAETQPAPNASPMKRSISTLAPRPHGTQLCNTVLDRPPPSQVSHHHHHRCHRRRDKKQRSLEKGPSLSVDTEGAPSTAAGSGLPHGEGSTGCRRERKQERGRSQERRQPSSSSSEKQRFYSCDRFGSREPPQPKPSLSSHPISPTAALEPGPHPQGSGSVNGSPLMSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPVHFAEGQSGLPAFSPGRLSRGLSEHNALLQKEPLSQPLASGSRIGSDPYLGQRLDSEASAHNLPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSTGVRARHSYHHPDQDHWC
uniprot
proteins
function
FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals. {ECO:0000269|PubMed:10938268, ECO:0000269|PubMed:1317580, ECO:0000269|PubMed:23699505}.
uniprot
proteins
mass_dalton
262256
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK. {ECO:0000269|PubMed:8125957}.
uniprot
proteins
protein_family
CACNA1B subfamily
uniprot
proteins
protein_family
Calcium channel alpha-1 subunit (TC 1.A.1.11) family
uniprot
proteins
pubmed
10938268
uniprot
proteins
pubmed
1317580
uniprot
proteins
pubmed
1692134
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23699505
uniprot
proteins
pubmed
7509046
uniprot
proteins
pubmed
8125957
uniprot
proteins
sequence_length
2336
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q00975}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 91..114; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 132..152; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 164..182; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 188..211; /note="Helical; Name=S4 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 222..244; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 332..356; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 484..502; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 513..535; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 546..567; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 575..587; /note="Helical; Name=S4 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 606..631; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 684..710; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1150..1168; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1177..1201; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1216..1240; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1247..1267; /note="Helical; Name=S4 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1286..1305; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1393..1418; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1474..1492; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1501..1525; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1536..1557; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1564..1582; /note="Helical; Name=S4 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1602..1621; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q00975"; TRANSMEM 1684..1707; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q00975
uniprot
proteins