Mcts1
entrez
68995
canonical
uniprot
Q9DB27
canonical
ensembl
ENSMUSG00000000355
resolver
ensp
ENSMUSP00000000365
resolver
genesymbol
Mcts1
resolver
uniprot
Q3UUI6
resolver
uniprot_entry
MCTS1_MOUSE
resolver
uniprot_sec
Q3UUI6
resolver
amino_acid_sequence
MFKKFDEKENVSNCIQLKTSVIKGIKNQLLEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTYK
uniprot
proteins
function
FUNCTION: Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent. Consequently, modulates various unrelated biological processes including cell cycle regulation and DNA damage signaling and repair. Notably, it positively regulates interferon gamma immunity to mycobacteria by enhancing the translation of JAK2. {ECO:0000250|UniProtKB:Q9ULC4}.
uniprot
proteins
mass_dalton
20555
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is critical for stabilization and promotion of cell proliferation. {ECO:0000250}.
uniprot
proteins
protein_family
MCTS1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
181
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9ULC4}. Note=Nuclear relocalization after DNA damage. {ECO:0000250|UniProtKB:Q9ULC4}.
uniprot
proteins