DUSP4
entrez
1846
canonical
uniprot
Q13115
canonical
ensembl
ENSG00000120875
resolver
ensp
ENSP00000240100
resolver
ensp
ENSP00000240101
resolver
genesymbol
DUSP4
resolver
genesymbol_syn
MKP2
resolver
genesymbol_syn
VH2
resolver
hgnc
HGNC:3070
resolver
uniprot
B2RBU5
resolver
uniprot
D3DSU4
resolver
uniprot
G5E930
resolver
uniprot
Q13524
resolver
uniprot_entry
DUS4_HUMAN
resolver
uniprot_sec
B2RBU5
resolver
uniprot_sec
D3DSU4
resolver
uniprot_sec
G5E930
resolver
uniprot_sec
Q13524
resolver
amino_acid_sequence
MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGYILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. {ECO:0000269|PubMed:7535768}.
uniprot
proteins
mass_dalton
42953
uniprot
proteins
post_translational_modification
PTM: Phosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein. {ECO:0000269|PubMed:21084841}.
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19415758
uniprot
proteins
pubmed
19843478
uniprot
proteins
pubmed
21084841
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25489052
uniprot
proteins
pubmed
7535768
uniprot
proteins
pubmed
8626452
uniprot
proteins
sequence_length
394
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7535768}.
uniprot
proteins