CASP12
entrez
100506742
canonical
uniprot
Q6UXS9
canonical
ensembl
ENSG00000204403
resolver
ensembl
ENSG00000291983
resolver
genesymbol
CASP12
resolver
hgnc
HGNC:19004
resolver
uniprot
D6RBN7
resolver
uniprot_entry
CASPC_HUMAN
resolver
uniprot_sec
D6RBN7
resolver
amino_acid_sequence
MADEKPSNGVLVHMVKLLIKTFLDGIFDDLMENNVLNTDEIHLIGKCLKFVVSNAENLVDDITETAQIAGKIFREHLWNSKKQLSSDISSDGEREANMPGLNIRNKEFNYLHNRNGSELDLLGMRDLLENLGYSVVIKENLTAQEMETALRQFAAHPEHQSSDSTFLVFMSHSILNGICGTKHWDQEPDVLHDDTIFEIFNNRNCQSLKDKPKVIIMQACRGNGAGIVWFTTDSGKASADTHGRLLQGNICNDAVTKAHVEKDFIAFKSSTPHNVSWRHETNGSVFISQIIYYFREYSWSHHLEEIFQKVQHSFETPNILTQLPTIERLSMTRYFYLFPGN
uniprot
proteins
function
FUNCTION: May function as a negative regulator of inflammatory responses and innate immunity. May reduce cytokine release in response to bacterial lipopolysaccharide during infection. Reduces activation of NF-kappa-B in response to TNF (PubMed:15129283). May lack protease activity (Probable). {ECO:0000269|PubMed:15129283, ECO:0000305|PubMed:12054529}.
uniprot
proteins
mass_dalton
38907
uniprot
proteins
protein_family
Peptidase C14A family
uniprot
proteins
pubmed
12054529
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15129283
uniprot
proteins
pubmed
16532395
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16917906
uniprot
proteins
sequence_length
341
uniprot
proteins