MGAT4A
entrez
11320
canonical
uniprot
Q9UM21
canonical
ensembl
ENSG00000071073
resolver
ensp
ENSP00000377127
resolver
ensp
ENSP00000404889
resolver
genesymbol
MGAT4A
resolver
hgnc
HGNC:7047
resolver
uniprot
B4E2R6
resolver
uniprot
D3DVH6
resolver
uniprot
E9PEN2
resolver
uniprot
Q53S97
resolver
uniprot
Q86Z15
resolver
uniprot_entry
MGT4A_HUMAN
resolver
uniprot_sec
B4E2R6
resolver
uniprot_sec
D3DVH6
resolver
uniprot_sec
E9PEN2
resolver
uniprot_sec
Q53S97
resolver
uniprot_sec
Q86Z15
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by UDP. {ECO:0000250|UniProtKB:O77836}.
uniprot
proteins
amino_acid_sequence
MRLRNGTVATALAFITSFLTLSWYTTWQNGKEKLIAYQREFLALKERLRIAEHRISQRSSELNTIVQQFKRVGAETNGSKDALNKFSDNTLKLLKELTSKKSLQVPSIYYHLPHLLKNEGSLQPAVQIGNGRTGVSIVMGIPTVKREVKSYLIETLHSLIDNLYPEEKLDCVIVVFIGETDIDYVHGVVANLEKEFSKEISSGLVEVISPPESYYPDLTNLKETFGDSKERVRWRTKQNLDYCFLMMYAQEKGIYYIQLEDDIIVKQNYFNTIKNFALQLSSEEWMILEFSQLGFIGKMFQAPDLTLIVEFIFMFYKEKPIDWLLDHILWVKVCNPEKDAKHCDRQKANLRIRFRPSLFQHVGLHSSLSGKIQKLTDKDYMKPLLLKIHVNPPAEVSTSLKVYQGHTLEKTYMGEDFFWAITPIAGDYILFKFDKPVNVESYLFHSGNQEHPGDILLNTTVEVLPFKSEGLEISKETKDKRLEDGYFRIGKFENGVAEGMVDPSLNPISAFRLSVIQNSAVWAILNEIHIKKATN
uniprot
proteins
ec_number
2.4.1.145
uniprot
proteins
function
FUNCTION: Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (PubMed:17006639). Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity). {ECO:0000250|UniProtKB:Q812G0, ECO:0000269|PubMed:17006639}.
uniprot
proteins
mass_dalton
61544
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:17006639}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:17006639}.
uniprot
proteins
protein_family
Glycosyltransferase 54 family
uniprot
proteins
pubmed
10024668
uniprot
proteins
pubmed
10463590
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16434023
uniprot
proteins
pubmed
17006639
uniprot
proteins
pubmed
26091039
uniprot
proteins
sequence_length
535
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A]: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9D4R2}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9D4R2}.; SUBCELLULAR LOCATION: [Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form]: Secreted {ECO:0000250|UniProtKB:O77836}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..27; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins