Slc25a21
entrez
217593
canonical
uniprot
Q8BZ09
canonical
ensembl
ENSMUSG00000035472
resolver
ensp
ENSMUSP00000039289
resolver
ensp
ENSMUSP00000106308
resolver
ensp
ENSMUSP00000151751
resolver
enst
ENSMUST00000044634
resolver
enst
ENSMUST00000110680
resolver
enst
ENSMUST00000217690
resolver
genesymbol
Slc25a21
resolver
genesymbol_syn
Odc
resolver
uniprot
B6CI26
resolver
uniprot
F6XDC7
resolver
uniprot
Q3TRZ4
resolver
uniprot
Q8BY72
resolver
uniprot_entry
B6CI26_MOUSE
resolver
uniprot_entry
F6XDC7_MOUSE
resolver
uniprot_entry
ODC_MOUSE
resolver
uniprot_entry
Q3TRZ4_MOUSE
resolver
uniprot_sec
Q8BY72
resolver
amino_acid_sequence
MSASNVSLLHETSRQVAAGGSAGLVEICLMHPLDVVKTRFQVQRSVTDPQSYRTVRGSFQMIFRTEGLFGFYKGIIPPILAETPKRAVKFSTFELYKKFLGYMSLSPGLTFLIAGLGSGLTEAVVVNPFEVVKVGLQVNRNLFKEQPSTFAYARQIIKKEGLGFQGLNKGLTATLGRHGIFNMVYFGFYHNVKNIIPSSKDPTLEFLRKFGIGFVSGTMGSVFNIPFDVAKSRIQGPQPVPGEIKYRSCFKTMEMIYREEGILALYKGLVPKVMRLGPGGGVMLLVYEYTYAWLQENW
uniprot
proteins
function
FUNCTION: Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle. {ECO:0000250|UniProtKB:Q9BQT8}.
uniprot
proteins
mass_dalton
33229
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
298
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 69..88; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 166..186; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 276..296; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins