Folh1
entrez
85309
canonical
uniprot
P70627
canonical
ensembl
ENSRNOG00000013770
resolver
ensembl
ENSRNOG00055019273
resolver
ensembl
ENSRNOG00060020113
resolver
ensembl
ENSRNOG00065028510
resolver
ensp
ENSRNOP00000018592
resolver
enst
ENSRNOT00000018592
resolver
genesymbol
Folh1
resolver
genesymbol_syn
Naalad1
resolver
uniprot
G3V7S0
resolver
uniprot
Q547B6
resolver
uniprot_entry
FOLH1_RAT
resolver
uniprot_entry
G3V7S0_RAT
resolver
uniprot_sec
Q547B6
resolver
activity_regulation
ACTIVITY REGULATION: The NAALADase activity is inhibited by beta-NAAG, quisqualic acid and 2-(phosphonomethyl)glutaric acid (PMG).
uniprot
proteins
amino_acid_sequence
MWNAQQDSDSAEALGRRQRWFCAGTLVLAFTGTFIIGFLFGWFIKPSNDSTSSVSYPGMKKAFLQELKAENIKKFLYNFTRTPHLAGTQHNFELAKQIHAQWKEFGLDLVELSDYDVLLSYPNKTHPNYISIINEDGNEIFKTSLAELSPPGYENISDVVPPYSAFSPQGTPEGDLVYVNYARTEDFFKLERVMKINCSGKIVIARYGQVFRGNKVKNAQLAGAKGIILYSDPADYFVPGVKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEYAYRHEFTEAVGLPSIPVHPIGYDDAQKLLEHMGGSAPPDSSWKGGLKVPYNVGPGFAGNFSKQKVKLHIHSYNKVTRIYNVIGTLKGAVEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEIVRTFGTLKKKGWRPRRTILFASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEGNYTLRVDCTPLMHSLVYNLTKELPSPDEGFEGKSLYDSWKEKSPSTEFIGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWKNNKVSSYPLYHSVYETYELVEKFYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQSYAVALKKHAETIYNISMNHPQEMKAYMISFDSLFSAVNNFTDVASKFNQRLQDLDKSNPILLRILNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDINNKVDTSKAWREVKRQISIAAFTVQAAAETLREVD
uniprot
proteins
ec_number
3.4.17.21
uniprot
proteins
function
FUNCTION: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides (By similarity). In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. {ECO:0000250}.; FUNCTION: Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. {ECO:0000250}.
uniprot
proteins
mass_dalton
84540
uniprot
proteins
protein_family
M28B subfamily
uniprot
proteins
protein_family
Peptidase M28 family
uniprot
proteins
pubmed
15019832
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
8570628
uniprot
proteins
pubmed
9375657
uniprot
proteins
pubmed
9501243
uniprot
proteins
sequence_length
752
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q04609}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q04609}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..44; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins