Rab8b
entrez
235442
canonical
uniprot
P61028
canonical
ensembl
ENSMUSG00000036943
resolver
ensp
ENSMUSP00000041857
resolver
enst
ENSMUST00000041139
resolver
genesymbol
Rab8b
resolver
genesymbol_syn
Rab8B
resolver
uniprot
Q0PD49
resolver
uniprot
Q3U1Z3
resolver
uniprot_entry
Q0PD49_MOUSE
resolver
uniprot_entry
RAB8B_MOUSE
resolver
uniprot_sec
Q3U1Z3
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including RAB3IP/RABIN8 which promotes the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:Q92930}.
uniprot
proteins
amino_acid_sequence
MAKTYDYLFKLLLIGDSGVGKTCLLFRFSEDAFNTTFISTIGIDFKIRTIELDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIKNWIRNIEEHASSDVERMILGNKCDMNDKRQVSKERGEKLAIDYGIKFLETSAKSSTNVEEAFFTLARDIMTKLNRKMNDSNSSGAGGPVKITESRSKKTSFFRCSLL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB8B may be involved in polarized vesicular trafficking and neurotransmitter release (By similarity). May participate in cell junction dynamics in Sertoli cells (By similarity). May also participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (By similarity). {ECO:0000250|UniProtKB:P61006, ECO:0000250|UniProtKB:P70550, ECO:0000250|UniProtKB:Q92930}.
uniprot
proteins
mass_dalton
23603
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2. {ECO:0000250|UniProtKB:Q92930}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18094055
uniprot
proteins
pubmed
18772196
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29125462
uniprot
proteins
sequence_length
207
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Endosome membrane {ECO:0000250|UniProtKB:Q92930}. Note=Recruited to phagosomes containing S.aureus or Mycobacterium. {ECO:0000250}.
uniprot
proteins