COQ3
entrez
51805
canonical
uniprot
Q9NZJ6
canonical
ensembl
ENSG00000132423
resolver
ensp
ENSP00000254759
resolver
ensp
ENSP00000631163
resolver
enst
ENST00000254759
resolver
genesymbol
COQ3
resolver
hgnc
HGNC:18175
resolver
uniprot
B3KPX0
resolver
uniprot
Q5T061
resolver
uniprot
Q6P4F0
resolver
uniprot
Q8IXG6
resolver
uniprot
Q96BG1
resolver
uniprot
Q9H0N1
resolver
uniprot_entry
COQ3_HUMAN
resolver
uniprot_sec
B3KPX0
resolver
uniprot_sec
Q5T061
resolver
uniprot_sec
Q6P4F0
resolver
uniprot_sec
Q8IXG6
resolver
uniprot_sec
Q96BG1
resolver
uniprot_sec
Q9H0N1
resolver
amino_acid_sequence
MWSGRKLGSSGGWFLRVLGPGGCNTKAARPLISSAVYVKNQLSGTLQIKPGVFNEYRTIWFKSYRTIFSCLNRIKSFRYPWARLYSTSQTTVDSGEVKTFLALAHKWWDEQGVYAPLHSMNDLRVPFIRDNLLKTIPNHQPGKPLLGMKILDVGCGGGLLTEPLGRLGASVIGIDPVDENIKTAQCHKSFDPVLDKRIEYRVCSLEEIVEETAETFDAVVASEVVEHVIDLETFLQCCCQVLKPGGSLFITTINKTQLSYALGIVFSEQIASIVPKGTHTWEKFVSPETLESILESNGLSVQTVVGMLYNPFSGYWHWSENTSLNYAAYAVKSRVQEHPASAEFVLKGETEELQANACTNPAVHEKLKK
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.114
uniprot
proteins
ec_number
2.1.1.64
uniprot
proteins
function
FUNCTION: O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis (By similarity) (PubMed:10777520, PubMed:38425362). Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoic acid (By similarity) (PubMed:10777520, PubMed:38425362). Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone (By similarity) (PubMed:38425362). Also able to mediate the methylation of 3-demethylubiquinol-10 into ubiquinol-10 (By similarity) (PubMed:10777520). {ECO:0000255|HAMAP-Rule:MF_03190, ECO:0000269|PubMed:10777520, ECO:0000269|PubMed:38425362}.
uniprot
proteins
mass_dalton
41054
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03190, ECO:0000269|PubMed:10777520, ECO:0000269|PubMed:38425362}.
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
UbiG/COQ3 family
uniprot
proteins
pubmed
10777520
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27499296
uniprot
proteins
pubmed
38425362
uniprot
proteins
sequence_length
369
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03190, ECO:0000269|PubMed:27499296}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03190}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03190}.
uniprot
proteins