CHRDL1
entrez
91851
canonical
uniprot
Q9BU40
canonical
ensembl
ENSG00000101938
resolver
ensp
ENSP00000361112
resolver
ensp
ENSP00000361115
resolver
ensp
ENSP00000399739
resolver
ensp
ENSP00000418443
resolver
ensp
ENSP00000551383
resolver
ensp
ENSP00000551384
resolver
ensp
ENSP00000551386
resolver
ensp
ENSP00000551388
resolver
ensp
ENSP00000551389
resolver
ensp
ENSP00000551390
resolver
genesymbol
CHRDL1
resolver
genesymbol_syn
NRLN1
resolver
hgnc
HGNC:29861
resolver
uniprot
B1AKD0
resolver
uniprot
B4DMP3
resolver
uniprot
D3DUY6
resolver
uniprot
E9PGS5
resolver
uniprot
Q539E4
resolver
uniprot
Q9Y3H7
resolver
uniprot_entry
CRDL1_HUMAN
resolver
uniprot_sec
B1AKD0
resolver
uniprot_sec
B4DMP3
resolver
uniprot_sec
D3DUY6
resolver
uniprot_sec
E9PGS5
resolver
uniprot_sec
Q539E4
resolver
uniprot_sec
Q9Y3H7
resolver
amino_acid_sequence
MRKKWKMGGMKYIFSLLFFLLLEGGKTEQVKHSETYCMFQDKKYRVGERWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPDSLPPVNNKVTSKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRGDGELSWEHSDGDIFRQPANREARHSYHRSHYDPPPSRQAGGLSRFPGARSHRGALMDSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVCPGKKAKELPGQSFDNKGYFCGEETMPVYESVFMEDGETTRKIALETERPPQVEVHVWTIRKGILQHFHIEKISKRMFEELPHFKLVTRTTLSQWKIFTEGEAQISQMCSSRVCRTELEDLVKVLYLERSEKGHC
uniprot
proteins
disease_involvement
DISEASE: Megalocornea 1, X-linked (MGC1) [MIM:309300]: An eye disorder in which the corneal diameter is bilaterally enlarged (greater than 13 mm) without an increase in intraocular pressure. It may also be referred to as anterior megalophthalmos, since the entire anterior segment is larger than normal. Features of megalocornea in addition to a deep anterior chamber include astigmatic refractive errors, atrophy of the iris stroma, miosis secondary to decreased function of the dilator muscle, iridodonesis, and tremulousness, subluxation, or dislocation of the lens. Whereas most affected individuals exhibit normal ocular function, complications include cataract development and glaucoma following lenticular dislocation or subluxation. {ECO:0000269|PubMed:22284829}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. {ECO:0000250, ECO:0000269|PubMed:18587495, ECO:0000269|PubMed:22284829}.
uniprot
proteins
mass_dalton
52026
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
18587495
uniprot
proteins
pubmed
22284829
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins