FRZB
entrez
2487
canonical
uniprot
Q92765
canonical
ensembl
ENSG00000162998
resolver
ensp
ENSP00000295113
resolver
enst
ENST00000295113
resolver
genesymbol
FRZB
resolver
genesymbol_syn
FIZ
resolver
genesymbol_syn
FRE
resolver
genesymbol_syn
FRP
resolver
genesymbol_syn
FRZB1
resolver
genesymbol_syn
SFRP3
resolver
hgnc
HGNC:3959
resolver
uniprot
O00181
resolver
uniprot
Q99686
resolver
uniprot_entry
SFRP3_HUMAN
resolver
uniprot_sec
O00181
resolver
uniprot_sec
Q99686
resolver
amino_acid_sequence
MVCGSPGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSERCKCKPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRDTVNLYTSSGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLSKSDSSNSDSTQSQKSGRNSNPRQARN
uniprot
proteins
disease_involvement
DISEASE: Osteoarthritis 1 (OS1) [MIM:165720]: A degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. {ECO:0000269|PubMed:15210948}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
uniprot
proteins
mass_dalton
36254
uniprot
proteins
protein_family
Secreted frizzled-related protein (sFRP) family
uniprot
proteins
pubmed
15210948
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19188438
uniprot
proteins
pubmed
8824257
uniprot
proteins
pubmed
9118218
uniprot
proteins
pubmed
9178261
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins