Dhrs7c
entrez
287411
canonical
uniprot
D3ZGP9
canonical
ensembl
ENSRNOG00000026548
resolver
ensp
ENSRNOP00000031559
resolver
enst
ENSRNOT00000036752
resolver
genesymbol
Dhrs7c
resolver
genesymbol_syn
Sdr32c2
resolver
uniprot_entry
DRS7C_RAT
resolver
amino_acid_sequence
MGIMAVLMLPLLLLGVSGLLFIYQEASRLWSKSAVQNKVVVITDALSGLGKECARVFNAGGARLVLCGKNWEGLESLYAALTSVADPSKTFTPKLVLLDLSDISCVEDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDANYFGPITFTKVLLPNMISRRTGQIVLVNNIQAKFGIPFRTAYAASKHAVMGFFDCLRAEVEEYDVVVSTVSPTFIRSYQAYPEQRNWGSSICKFFCRKLTYGVHPVEVAEEVMRTVRRKKQEVFMANPVPKAAVFIRTFFPELFFAVVACGVKEKLSVPEEG
uniprot
proteins
ec_number
1.1.1.105
uniprot
proteins
function
FUNCTION: NADH-dependent oxidoreductase which catalyzes the oxidation of all-trans-retinol to all-trans-retinal. Plays a role in the regulation of cardiac and skeletal muscle metabolic functions. Maintains Ca(2+) intracellular homeostasis by repressing Ca(2+) release from the sarcoplasmic reticulum (SR) in myotubes, possibly through local alternations in NAD/NADH or retinol/retinal. Also plays a role in Ca(2+) homeostasis by controlling Ca(2+) overload in the cytosol and the SR in myotubes. Involved in glucose uptake into skeletal muscles and muscle performance by activating PI3K and mTORC2-mediated AKT1 phosphorylation signaling pathways, possibly through the action of its downstream catalytic product all-trans-retinoic acid. {ECO:0000250|UniProtKB:Q8CHS7}.
uniprot
proteins
mass_dalton
34366
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22143674
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8CHS7}. Note=The N-terminus region encompasses a short hydrophobic sequence bound to the sarcoplasmic reticulum membrane, whereas the C-terminus catalytic domain faces the myoplasm. {ECO:0000250|UniProtKB:Q8CHS7}.
uniprot
proteins