Gpr6
entrez
140741
canonical
uniprot
Q6YNI2
canonical
ensembl
ENSMUSG00000046922
resolver
ensp
ENSMUSP00000057323
resolver
enst
ENSMUST00000061796
resolver
genesymbol
Gpr6
resolver
genesymbol_syn
Gm233
resolver
uniprot_entry
GPR6_MOUSE
resolver
amino_acid_sequence
MNASAAALNESQVVAVAAEGAAAAATAAGAPDTGEWGPPAASAALGGGGGPNGSLELSSQLPAGPSGLLLSAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYVVPSETVSLLMVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLADRTSCSVVRPLTRSHVALLSTSFFVVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSQEDPAIYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLFCGCFQSKVPFRSRSPSEV
uniprot
proteins
function
FUNCTION: Constitutively active G protein-coupled receptor that maintains high cAMP levels and contributes to several processes including neuronal development, through activation of intracellular signaling pathways via G(s) (PubMed:17284443). May be activated by lipid-derived agonists such as oleic acid or sphingosine 1-phosphate, leading to activation of the G(s)/cAMP/PKA signaling pathway (PubMed:24747358). {ECO:0000269|PubMed:17284443, ECO:0000269|PubMed:24747358}.
uniprot
proteins
mass_dalton
38085
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14592418
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17284443
uniprot
proteins
pubmed
17934457
uniprot
proteins
pubmed
24747358
uniprot
proteins
sequence_length
363
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:17284443}; Multi-pass membrane protein {ECO:0000305|PubMed:17284443}. Note=Highly expressed and localized along the cytoplasmic membrane as well as in a perinuclear compartment.
uniprot
proteins
transmembrane_region
TRANSMEM 76..95; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 108..131; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 144..165; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 187..206; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 232..250; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 279..305; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 311..332; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins