Retreg2
entrez
363252
canonical
uniprot
Q3MHU5
canonical
ensembl
ENSRNOG00000018586
resolver
ensp
ENSRNOP00000054145
resolver
ensp
ENSRNOP00000071987
resolver
enst
ENSRNOT00000057330
resolver
enst
ENSRNOT00000078260
resolver
genesymbol
Retreg2
resolver
genesymbol_syn
Fam134a
resolver
uniprot
A0A0G2K1U5
resolver
uniprot_entry
A0A0G2K1U5_RAT
resolver
uniprot_entry
RETR2_RAT
resolver
amino_acid_sequence
MASSGGGNTGAGGTSGLGLGLGLGLCMGEATGDAEEEAAAAEAVGRLATSLWLRLRGWEAVLAAAQRLLVWEKPLHSLVTAATLNGLFWLLSSSSLRPFFLLSISLLTYFLLDLWHPRFLPDVSAPPPEEPHSDSEGAGSGAQPHLLSVPELCRYLAESWLTFQIHLQELLQYKRQNPAQFCARVCSGCAVLAVLGHYVPGIMISYIVLLSILLWPLVVYHELIQRMYTRLEPLLMQLDYSMKAEADALHHKHDKRKRQGKNAPPAGDEPLAETESESEAELAGFSPVVDVKKTALALAITDSELSDEEASILESGGFSVSRATTPQLTDVSEDLDQQSLPSEPEEALSRELGDGEETELAPPEDLLSAPPALSKQALDTEEEGAADKETLLQLSSPLHFVNTHFNGAGSPQEGVKCPPGGPVETLSPEAVSGDLMAPSSTLSPQLCLAESGPVTLLSPSVLPSLPQDSPQALTAPEEEEALTTEDFELLDQGELEQLNAELGLGPEMPPKPPDVLPPPPLGPDSHSLVQSDQEAHAVVEP
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress. When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins. Required for collagen quality control in a LIR motif-independent manner. {ECO:0000250|UniProtKB:Q6NS82, ECO:0000250|UniProtKB:Q8NC44}.
uniprot
proteins
mass_dalton
57659
uniprot
proteins
protein_family
RETREG family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8NC44}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 75..91; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 99..115; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 199..219; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins