Mt-co2
entrez
26198
canonical
uniprot
P00406
canonical
genesymbol
Mt-co2
resolver
genesymbol_syn
CO2
resolver
genesymbol_syn
COII
resolver
genesymbol_syn
COX2
resolver
genesymbol_syn
COXII
resolver
genesymbol_syn
Coii
resolver
genesymbol_syn
Mtco2
resolver
genesymbol_syn
mt-Co3
resolver
genesymbol_syn
mt-Nd4l
resolver
uniprot
Q37738
resolver
uniprot
Q80WI7
resolver
uniprot
Q8SEZ5
resolver
uniprot_entry
COX2_RAT
resolver
uniprot_entry
Q8SEZ5_RAT
resolver
uniprot_sec
Q37738
resolver
uniprot_sec
Q80WI7
resolver
amino_acid_sequence
MAYPFQLGLQDATSPIMEELTNFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAVILILIALPSLRILYMMDEINNPVLTVKTMGHQWYWSYEYTDYEDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKYFENWSASMI
uniprot
proteins
ec_number
7.1.1.9
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00410}.
uniprot
proteins
mass_dalton
25928
uniprot
proteins
protein_family
Cytochrome c oxidase subunit 2 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
1848093
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2504926
uniprot
proteins
pubmed
6091655
uniprot
proteins
pubmed
6285344
uniprot
proteins
pubmed
7981121
uniprot
proteins
sequence_length
227
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P68530}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P68530}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..45; /note="Helical; Name=I"; /evidence="ECO:0000250|UniProtKB:P68530"; TRANSMEM 60..87; /note="Helical; Name=II"; /evidence="ECO:0000250|UniProtKB:P68530
uniprot
proteins