PHLPP2
entrez
23035
canonical
uniprot
Q6ZVD8
canonical
ensembl
ENSG00000040199
resolver
ensp
ENSP00000377159
resolver
ensp
ENSP00000457991
resolver
genesymbol
PHLPP2
resolver
genesymbol_syn
KIAA0931
resolver
genesymbol_syn
PHLPPL
resolver
hgnc
HGNC:29149
resolver
uniprot
A1L374
resolver
uniprot
Q9NV17
resolver
uniprot
Q9Y2E3
resolver
uniprot_entry
PHLP2_HUMAN
resolver
uniprot_sec
A1L374
resolver
uniprot_sec
Q9NV17
resolver
uniprot_sec
Q9Y2E3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by AKT1, AKT2 and AKT3. Activated by oleic acid and arachidonic acid (PubMed:24892992). {ECO:0000269|PubMed:24892992, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MKRNGSRNCLNRRSRFGSRERDWLREDVKRGCVYLYGADTTTATTTTTTSSSSSSSSSSSDLHLVLCTVETPASEICAGEGRESLYLQLHGDLVRRLEPTERPLQIVYDYLSRLGFDDPVRIQEEATNPDLGCMIRFYGEKPCHMDRLDRILLSGIYNVRKGKTQLHKWAERLVVLCGTCLIVSSVKDCQTGKMHILPLVGGKIEEVKRRQYSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPLPTTDSTVTSTFWSHGLAEMAGQRNKLCVSALAMDSFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEVQQSTNDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPASSFSLTVANVGTCQAVLCRGGKPVPLSKVFSLEQDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNIGEEGCTCEMNGLTLPGPVGFASTTTIKDAPKPATPSSSSGIASEFSSEMSTSEVSSEVGSTASDEHNAGGLDTALLPRPERRCSLHPTPTSGLFQRQPSSATFSSNQSDNGLDSDDDQPVEGVITNGSKVEVEVDIHCCRGRDLENSPPLIESSPTLCSEEHARGSCFGIRRQNSVNSGMLLPMSKDRMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATEVPKRKTGYFAAPTQMEPEDQFVVPHDLEEEVKEQMKQHQDSRLEPEPHEEDRTEPPEEFDTAL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). {ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:20513427, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}.
uniprot
proteins
mass_dalton
146751
uniprot
proteins
mutagenesis
MUTAGEN 783; /note="F->V: Decreases activity."; /evidence="ECO:0000269|PubMed:24892992"; MUTAGEN 806; /note="D->N: Decreases activity."; /evidence="ECO:0000269|PubMed:24892992"; MUTAGEN 808; /note="F->V: Abolishes activity."; /evidence="ECO:0000269|PubMed:24892992"; MUTAGEN 989; /note="E->Q: Decreases activity."; /evidence="ECO:0000269|PubMed:24892992"; MUTAGEN 1024; /note="D->N: Decreases activity."; /evidence="ECO:0000269|PubMed:24892992
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17386267
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18162466
uniprot
proteins
pubmed
19079341
uniprot
proteins
pubmed
19732725
uniprot
proteins
pubmed
20513427
uniprot
proteins
pubmed
21804599
uniprot
proteins
pubmed
21986499
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24530606
uniprot
proteins
pubmed
24892992
uniprot
proteins
pubmed
40168118
uniprot
proteins
sequence_length
1323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus.
uniprot
proteins