EMC3
entrez
55831
canonical
uniprot
Q9P0I2
canonical
ensembl
ENSG00000125037
resolver
ensp
ENSP00000245046
resolver
ensp
ENSP00000474771
resolver
ensp
ENSP00000775656
resolver
genesymbol
EMC3
resolver
genesymbol_syn
TMEM111
resolver
hgnc
HGNC:23999
resolver
uniprot
B2R4Z9
resolver
uniprot
Q53GH8
resolver
uniprot
Q6ZMC2
resolver
uniprot_entry
EMC3_HUMAN
resolver
uniprot_sec
B2R4Z9
resolver
uniprot_sec
Q53GH8
resolver
uniprot_sec
Q6ZMC2
resolver
amino_acid_sequence
MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLRSIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKAFKTEWEALELTDHQWALDDVEEELMAKDLHFEGMFKKELQTSIF
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000305}.
uniprot
proteins
mass_dalton
29952
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="R->A,E: No effect on EMC assembly but decreased membrane insertion of hydrophobic transmembrane helices-containing proteins by the EMC."; /evidence="ECO:0000269|PubMed:32439656"; MUTAGEN 31; /note="R->K: No effect on EMC assembly and no effect on membrane insertion of hydrophobic transmembrane helices-containing proteins by the EMC."; /evidence="ECO:0000269|PubMed:32439656"; MUTAGEN 101; /note="M->S: No effect on EMC assembly but decreased membrane insertion of hydrophobic transmembrane helices-containing proteins by the EMC; when associated S-106, S-110 and S-111."; /evidence="ECO:0000269|PubMed:32439656"; MUTAGEN 106; /note="M->S: No effect on EMC assembly but decreased membrane insertion of hydrophobic transmembrane helices-containing proteins by the EMC; when associated S-101, S-110 and S-111."; /evidence="ECO:0000269|PubMed:32439656"; MUTAGEN 110; /note="M->S: No effect on EMC assembly but decreased membrane insertion of hydrophobic transmembrane helices-containing proteins by the EMC; when associated S-101, S-106 and S-111."; /evidence="ECO:0000269|PubMed:32439656"; MUTAGEN 111; /note="M->S: No effect on EMC assembly but decreased membrane insertion of hydrophobic transmembrane helices-containing proteins by the EMC; when associated S-101, S-106 and S-110."; /evidence="ECO:0000269|PubMed:32439656"; MUTAGEN 173; /note="F->A: No effect on EMC assembly and no effect on membrane insertion of hydrophobic transmembrane helices-containing proteins by the EMC."; /evidence="ECO:0000269|PubMed:32439656"; MUTAGEN 180; /note="R->A,E: No effect on EMC assembly but decreased membrane insertion of hydrophobic transmembrane helices-containing proteins by the EMC."; /evidence="ECO:0000269|PubMed:32439656"; MUTAGEN 180; /note="R->K: No effect on EMC assembly and no effect on membrane insertion of hydrophobic transmembrane helices-containing proteins by the EMC."; /evidence="ECO:0000269|PubMed:32439656
uniprot
proteins
protein_family
EMC3 family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22119785
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29242231
uniprot
proteins
pubmed
29809151
uniprot
proteins
pubmed
30415835
uniprot
proteins
pubmed
32439656
uniprot
proteins
pubmed
32459176
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785}; Multi-pass membrane protein {ECO:0000269|PubMed:32439656}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..38; /note="Helical"; /evidence="ECO:0000269|PubMed:32439656"; TRANSMEM 115..130; /note="Helical"; /evidence="ECO:0000269|PubMed:32439656"; TRANSMEM 169..187; /note="Helical"; /evidence="ECO:0000269|PubMed:32439656
uniprot
proteins