Ilf2
entrez
67781
canonical
uniprot
Q9CXY6
canonical
ensembl
ENSMUSG00000001016
resolver
ensp
ENSMUSP00000001042
resolver
enst
ENSMUST00000001042
resolver
genesymbol
Ilf2
resolver
genesymbol_syn
Nf45
resolver
uniprot
Q3U083
resolver
uniprot
Q5RKG0
resolver
uniprot
Q8CCY9
resolver
uniprot
Q99KS3
resolver
uniprot_entry
ILF2_MOUSE
resolver
uniprot_sec
Q3U083
resolver
uniprot_sec
Q5RKG0
resolver
uniprot_sec
Q8CCY9
resolver
uniprot_sec
Q99KS3
resolver
amino_acid_sequence
MRGDRGRGRGGRFGSRGGPGGGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKRNQDLAPNSAEQASILSLVTKINNVIDNLIVAPGTFEVQIEEVRQVGSYKKGTMTTGHNVADLVVILKILPTLEAVAALGNKVVESLRAQDPSEVLTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEKKEGEEEEENTEEPPQGEEEESMETQE
uniprot
proteins
function
FUNCTION: Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth (PubMed:10574923). Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay. Also plays a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71 (By similarity) (PubMed:10574923). {ECO:0000250|UniProtKB:Q12905, ECO:0000269|PubMed:10574923}.
uniprot
proteins
mass_dalton
43062
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated at Lys-45 by CRBN with polyubiquitin chains by the CUL4-RING E3 ligase (CRL4-CRBN) and then degraded by the proteasome. {ECO:0000250|UniProtKB:Q12905}.
uniprot
proteins
pubmed
10574923
uniprot
proteins
pubmed
11804788
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
7519613
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q12905}. Cytoplasm {ECO:0000250|UniProtKB:Q12905}. Nucleus {ECO:0000250|UniProtKB:Q12905}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250|UniProtKB:Q12905}.
uniprot
proteins