RAD1
entrez
5810
canonical
uniprot
O60671
canonical
ensembl
ENSG00000113456
resolver
ensp
ENSP00000371469
resolver
genesymbol
RAD1
resolver
genesymbol_syn
REC1
resolver
hgnc
HGNC:9806
resolver
uniprot
O75572
resolver
uniprot
O95304
resolver
uniprot
Q1W161
resolver
uniprot
Q5KSM0
resolver
uniprot
Q5KSM1
resolver
uniprot
Q9UEP1
resolver
uniprot_entry
RAD1_HUMAN
resolver
uniprot_sec
O75572
resolver
uniprot_sec
O95304
resolver
uniprot_sec
Q1W161
resolver
uniprot_sec
Q5KSM0
resolver
uniprot_sec
Q5KSM1
resolver
uniprot_sec
Q9UEP1
resolver
amino_acid_sequence
MPLLTQQIQDEDDQYSLVASLDNVRNLSTILKAIHFREHATCFATKNGIKVTVENAKCVQANAFIQAGIFQEFKVQEESVTFRINLTVLLDCLSIFGSSPMPGTLTALRMCYQGYGYPLMLFLEEGGVVTVCKINTQEPEETLDFDFCSTNVINKIILQSEGLREAFSELDMTSEVLQITMSPDKPYFRLSTFGNAGSSHLDYPKDSDLMEAFHCNQTQVNRYKISLLKPSTKALVLSCKVSIRTDNRGFLSLQYMIRNEDGQICFVEYYCCPDEEVPESES
uniprot
proteins
function
FUNCTION: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). {ECO:0000269|PubMed:10846170, ECO:0000269|PubMed:10884395, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:15314187, ECO:0000269|PubMed:15556996, ECO:0000269|PubMed:15871698, ECO:0000269|PubMed:21659603}.
uniprot
proteins
mass_dalton
31827
uniprot
proteins
mutagenesis
MUTAGEN 64; /note="F->A: Reduced binding to RHNO1; when associated with A-256 and A-266."; /evidence="ECO:0000269|PubMed:31776186"; MUTAGEN 155; /note="K->A: Reduced binding to RHNO1; when associated with A-244 and A-254."; /evidence="ECO:0000269|PubMed:31776186"; MUTAGEN 226..233; /note="SLLKPSTK->AAAAAAAA: Abolishes association of the 9-1-1 complex with RAD17."; /evidence="ECO:0000269|PubMed:10884395"; MUTAGEN 244; /note="R->A: Reduced binding to RHNO1; when associated with A-155 and A-254."; /evidence="ECO:0000269|PubMed:31776186"; MUTAGEN 254; /note="Q->A: Reduced binding to RHNO1; when associated with A-155 and A-244."; /evidence="ECO:0000269|PubMed:31776186"; MUTAGEN 256; /note="M->A: Reduced binding to RHNO1; when associated with A-64 and A-266."; /evidence="ECO:0000269|PubMed:31776186"; MUTAGEN 266; /note="F->A: Reduced binding to RHNO1; when associated with A-64 and A-256."; /evidence="ECO:0000269|PubMed:31776186
uniprot
proteins
protein_family
Rad1 family
uniprot
proteins
pubmed
10359610
uniprot
proteins
pubmed
10777662
uniprot
proteins
pubmed
10846170
uniprot
proteins
pubmed
10884395
uniprot
proteins
pubmed
11573955
uniprot
proteins
pubmed
11944979
uniprot
proteins
pubmed
12578958
uniprot
proteins
pubmed
14500360
uniprot
proteins
pubmed
14611806
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15314187
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15556996
uniprot
proteins
pubmed
15871698
uniprot
proteins
pubmed
15897895
uniprot
proteins
pubmed
16216273
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21659603
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
31776186
uniprot
proteins
pubmed
36841485
uniprot
proteins
pubmed
9660799
uniprot
proteins
pubmed
9705507
uniprot
proteins
pubmed
9716408
uniprot
proteins
pubmed
9828137
uniprot
proteins
pubmed
9828139
uniprot
proteins
pubmed
9878245
uniprot
proteins
sequence_length
282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9716408}.
uniprot
proteins