Q811U3
uniprot
Q811U3
canonical
amino_acid_sequence
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGAETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENNMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALADKERTIERLKEQRDRDEREKQEEIDTYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEATLEARASPEMSDRIQQLEREIARYKDESSKAQTEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDSLSDSSQQLQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFRSSRSNQTNHKPSPDQDEEEGIWA
uniprot
proteins
function
FUNCTION: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex (By similarity). May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000250}.
uniprot
proteins
mass_dalton
108818
uniprot
proteins
mutagenesis
MUTAGEN 943; /note="E->K,A: No effect on RIMS1 and RIMS2 binding."; /evidence="ECO:0000269|PubMed:12391317"; MUTAGEN 944; /note="E->K,A: No effect on RIMS1 and RIMS2 binding."; /evidence="ECO:0000269|PubMed:12391317"; MUTAGEN 945; /note="G->D,A: Abolishes RIMS1 and RIMS2 binding."; /evidence="ECO:0000269|PubMed:12391317"; MUTAGEN 946; /note="I->D,A: Abolishes RIMS1 and RIMS2 binding."; /evidence="ECO:0000269|PubMed:12391317"; MUTAGEN 947; /note="W->D,A: Abolishes RIMS1 and RIMS2 binding."; /evidence="ECO:0000269|PubMed:12391317"; MUTAGEN 948; /note="A->D: Abolishes RIMS1 and RIMS2 binding."; /evidence="ECO:0000269|PubMed:12391317"; MUTAGEN 948; /note="A->L: Weakens RIMS1 and abolishes RIMS2 binding."; /evidence="ECO:0000269|PubMed:12391317
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in an N-terminal region by SRPK1 and/or SRPK2. {ECO:0000269|PubMed:30745339}.
uniprot
proteins
pubmed
12391317
uniprot
proteins
pubmed
14723704
uniprot
proteins
pubmed
16095618
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
30745339
uniprot
proteins
sequence_length
948
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8IUD2}. Cytoplasm {ECO:0000269|PubMed:12391317}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Presynaptic active zone {ECO:0000269|PubMed:12391317}. Cell projection, podosome {ECO:0000250|UniProtKB:Q99MI1}. Note=Recruited on Golgi membranes by RAB6A in a GTP-dependent manner. Localized to the cortex of myotube podosomes (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q99MI1}.
uniprot
proteins