Oaz3
entrez
689588
canonical
uniprot
A1BPI0
canonical
ensembl
ENSRNOG00000020863
resolver
ensembl
ENSRNOG00055032311
resolver
ensembl
ENSRNOG00060013679
resolver
ensembl
ENSRNOG00065025626
resolver
ensp
ENSRNOP00000028303
resolver
ensp
ENSRNOP00055045963
resolver
ensp
ENSRNOP00060018537
resolver
ensp
ENSRNOP00065036311
resolver
enst
ENSRNOT00055055797
resolver
enst
ENSRNOT00060023379
resolver
enst
ENSRNOT00065044230
resolver
genesymbol
Oaz3
resolver
uniprot
F1LSS2
resolver
uniprot_entry
OAZ3_RAT
resolver
uniprot_sec
F1LSS2
resolver
amino_acid_sequence
MPCTRSRPSLYSLSYIKRGKTRNCLYPFWSPYAYYLYCYKYRITLREKMLPCCYRSITYKEQEDLTLRPHCCLPCSCLPYSCLPCSESLEGLQVGRSTAQEKDHSQLKELYSAGNLTVLSADPLLHQDPVQLDFHFRLTPHSSAHWHGLLCDHQLFLDIPFQALEQGNRESLTATLEYVEEKTNVDSVFVNFQSNHKDRGALLRAFSYMGFEVVRPDHPALPPWDNVIFMVYPLERDLGQPGQ
uniprot
proteins
function
FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity). {ECO:0000250|UniProtKB:Q9R109, ECO:0000250|UniProtKB:Q9UMX2}.; FUNCTION: [Isoform 2]: Does not possess antizyme activity. Modulates PPP1CB activity through its interaction with PPP1R16A. {ECO:0000269|PubMed:21712390}.
uniprot
proteins
mass_dalton
28185
uniprot
proteins
protein_family
ODC antizyme family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17040916
uniprot
proteins
pubmed
21712390
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
243
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:Q9R109}. Cytoplasm {ECO:0000250|UniProtKB:Q9R109}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell projection, cilium, flagellum {ECO:0000269|PubMed:21712390}.
uniprot
proteins