JUP
entrez
3728
canonical
uniprot
P14923
canonical
ensembl
ENSG00000173801
resolver
ensp
ENSP00000311113
resolver
ensp
ENSP00000377507
resolver
ensp
ENSP00000377508
resolver
ensp
ENSP00000555320
resolver
ensp
ENSP00000555321
resolver
ensp
ENSP00000555322
resolver
ensp
ENSP00000555323
resolver
ensp
ENSP00000555324
resolver
ensp
ENSP00000555325
resolver
ensp
ENSP00000555327
resolver
ensp
ENSP00000555328
resolver
ensp
ENSP00000555329
resolver
ensp
ENSP00000555330
resolver
ensp
ENSP00000555331
resolver
ensp
ENSP00000555332
resolver
ensp
ENSP00000555333
resolver
ensp
ENSP00000555334
resolver
ensp
ENSP00000555335
resolver
ensp
ENSP00000555336
resolver
ensp
ENSP00000555337
resolver
ensp
ENSP00000588720
resolver
ensp
ENSP00000588721
resolver
ensp
ENSP00000588722
resolver
ensp
ENSP00000588723
resolver
ensp
ENSP00000588724
resolver
ensp
ENSP00000588725
resolver
ensp
ENSP00000588726
resolver
ensp
ENSP00000588727
resolver
ensp
ENSP00000626008
resolver
ensp
ENSP00000626009
resolver
ensp
ENSP00000626010
resolver
ensp
ENSP00000626011
resolver
ensp
ENSP00000705307
resolver
enst
ENST00000310706
resolver
enst
ENST00000393930
resolver
enst
ENST00000393931
resolver
enst
ENST00000885261
resolver
enst
ENST00000885262
resolver
enst
ENST00000885263
resolver
enst
ENST00000885264
resolver
enst
ENST00000885265
resolver
enst
ENST00000885266
resolver
enst
ENST00000885268
resolver
enst
ENST00000885269
resolver
enst
ENST00000885270
resolver
enst
ENST00000885271
resolver
enst
ENST00000885272
resolver
enst
ENST00000885273
resolver
enst
ENST00000885274
resolver
enst
ENST00000885275
resolver
enst
ENST00000885276
resolver
enst
ENST00000885277
resolver
enst
ENST00000885278
resolver
enst
ENST00000918661
resolver
enst
ENST00000918662
resolver
enst
ENST00000918663
resolver
enst
ENST00000918664
resolver
enst
ENST00000918665
resolver
enst
ENST00000918666
resolver
enst
ENST00000918667
resolver
enst
ENST00000918668
resolver
enst
ENST00000955949
resolver
enst
ENST00000955950
resolver
enst
ENST00000955951
resolver
enst
ENST00000955952
resolver
genesymbol
JUP
resolver
genesymbol_syn
CTNNG
resolver
genesymbol_syn
DP3
resolver
hgnc
HGNC:6207
resolver
uniprot
A0A0S2Z487
resolver
uniprot
Q15093
resolver
uniprot
Q15151
resolver
uniprot
Q7L3S5
resolver
uniprot
Q86W21
resolver
uniprot
Q9BWC4
resolver
uniprot
Q9HCX9
resolver
uniprot_entry
A0A0S2Z487_HUMAN
resolver
uniprot_entry
PLAK_HUMAN
resolver
uniprot_sec
Q15093
resolver
uniprot_sec
Q15151
resolver
uniprot_sec
Q7L3S5
resolver
uniprot_sec
Q86W21
resolver
uniprot_sec
Q9BWC4
resolver
uniprot_sec
Q9HCX9
resolver
amino_acid_sequence
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDMDGDYPIDTYSDGLRPPYPTADHMLA
uniprot
proteins
disease_involvement
DISEASE: Naxos disease (NXD) [MIM:601214]: An autosomal recessive disorder characterized by the association of diffuse non-epidermolytic palmoplantar keratoderma with woolly hair and cardiac abnormalities such as dilated cardiomyopathy and arrhythmogenic right ventricular dysplasia. {ECO:0000269|PubMed:10902626}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Arrhythmogenic right ventricular dysplasia, familial, 12 (ARVD12) [MIM:611528]: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias. {ECO:0000269|PubMed:17924338, ECO:0000269|PubMed:20031617}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q02257}.
uniprot
proteins
mass_dalton
81745
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="T->A: Abolishes glycosylation. Does not affect binding to CDH1, DSC1 or DSG1."; /evidence="ECO:0000269|PubMed:12847106"; MUTAGEN 19; /note="T->A: Reduces glycosylation."; /evidence="ECO:0000269|PubMed:12847106"; MUTAGEN 21; /note="T->A: Does not affect glycosylation."; /evidence="ECO:0000269|PubMed:12847106"; MUTAGEN 24; /note="S->A: Does not affect glycosylation."; /evidence="ECO:0000269|PubMed:12847106"; MUTAGEN 28; /note="S->A: Does not affect glycosylation."; /evidence="ECO:0000269|PubMed:12847106"; MUTAGEN 32; /note="T->A: Does not affect glycosylation."; /evidence="ECO:0000269|PubMed:12847106
uniprot
proteins
post_translational_modification
PTM: Cleaved by CASP3 in response to apoptosis. {ECO:0000269|PubMed:17559062}.; PTM: May be phosphorylated by FER. {ECO:0000269|PubMed:14517306}.
uniprot
proteins
protein_family
Beta-catenin family
uniprot
proteins
pubmed
10902626
uniprot
proteins
pubmed
11016852
uniprot
proteins
pubmed
11790773
uniprot
proteins
pubmed
12370829
uniprot
proteins
pubmed
12847106
uniprot
proteins
pubmed
14517306
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16917092
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17559062
uniprot
proteins
pubmed
17924338
uniprot
proteins
pubmed
19136012
uniprot
proteins
pubmed
19759396
uniprot
proteins
pubmed
19863551
uniprot
proteins
pubmed
20031617
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20859650
uniprot
proteins
pubmed
21062920
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21495994
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22781308
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25208567
uniprot
proteins
pubmed
26604139
uniprot
proteins
pubmed
2726765
uniprot
proteins
pubmed
31845994
uniprot
proteins
pubmed
33784018
uniprot
proteins
pubmed
7982500
uniprot
proteins
pubmed
8631907
uniprot
proteins
pubmed
9139698
uniprot
proteins
pubmed
9152027
uniprot
proteins
sequence_length
745
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:22781308}. Cell junction, desmosome {ECO:0000269|PubMed:21495994, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:26604139}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22781308}. Cell membrane {ECO:0000269|PubMed:11790773, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:22781308}; Peripheral membrane protein {ECO:0000269|PubMed:22781308}. Cytoplasm {ECO:0000250|UniProtKB:Q9PVF7}. Cell junction {ECO:0000250|UniProtKB:Q9PVF7}. Nucleus {ECO:0000250|UniProtKB:Q9PVF7}. Cell projection, axon {ECO:0000250|UniProtKB:Q02257}. Note=Cytoplasmic in a soluble and membrane-associated form. Colocalizes with DSG4 at desmosomes (PubMed:21495994). {ECO:0000269|PubMed:21495994}.
uniprot
proteins