C5ar1
entrez
113959
canonical
uniprot
P97520
canonical
ensembl
ENSRNOG00000074439
resolver
ensembl
ENSRNOG00060020768
resolver
ensp
ENSRNOP00000098952
resolver
ensp
ENSRNOP00000110658
resolver
ensp
ENSRNOP00060029603
resolver
enst
ENSRNOT00000132351
resolver
enst
ENSRNOT00000146559
resolver
enst
ENSRNOT00060035976
resolver
genesymbol
C5ar1
resolver
genesymbol_syn
C5r1
resolver
uniprot
A0ABK0KWS8
resolver
uniprot
O09088
resolver
uniprot_entry
A0ABK0KWS8_RAT
resolver
uniprot_entry
C5AR1_RAT
resolver
uniprot_sec
O09088
resolver
amino_acid_sequence
MDPISNDSSEITYDYSDGTPNPDMPADGVYIPKMEPGDIAALIIYLAVFLVGVTGNALVVWVTAFEAKRTVNAIWFLNLAVADLLSCLALPILFTSIVKHNHWPFGDQACIVLPSLILLNMYSSILLLATISADRFLLVFKPIWCQKFRRPGLAWMACGVTWVLALLLTIPSFVFRRIHKDPYSDSILCNIDYSKGPFFIEKAIAILRLMVGFVLPLLTLNICYTFLLIRTWSRKATRSTKTLKVVMAVVTCFFVFWLPYQVTGVILAWLPRSSSTFQSVERLNSLCVSLAYINCCVNPIIYVMAGQGFHGRLRRSLPSIIRNVLSEDSLGRDSKSFTRSTMDTSTQKSQAV
uniprot
proteins
function
FUNCTION: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:9464523). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase (By similarity). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (By similarity). {ECO:0000250|UniProtKB:P21730, ECO:0000269|PubMed:9464523}.
uniprot
proteins
mass_dalton
39417
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of the P-X-P-P motif by GRK2 or GRK3 in response to C5a binding promotes association with beta-arrestin (ARRB1 and/or ARRB2), resulting in internalization of the receptor and short-term desensitization to the ligand. {ECO:0000250|UniProtKB:P21730}.; PTM: Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small a small peptide agonist. {ECO:0000250|UniProtKB:P21730}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12464600
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9272704
uniprot
proteins
pubmed
9464523
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12464600, ECO:0000269|PubMed:9464523}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P21730}. Cytoplasmic vesicle {ECO:0000269|PubMed:12464600}. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. {ECO:0000250|UniProtKB:P21730}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..65; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P21730"; TRANSMEM 71..94; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P21730"; TRANSMEM 112..133; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P21730"; TRANSMEM 155..175; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P21730"; TRANSMEM 203..228; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P21730"; TRANSMEM 245..267; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P21730"; TRANSMEM 285..305; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P21730
uniprot
proteins