Dnase1
entrez
13419
canonical
uniprot
P49183
canonical
ensembl
ENSMUSG00000005980
resolver
ensp
ENSMUSP00000006136
resolver
ensp
ENSMUSP00000113119
resolver
enst
ENSMUST00000006136
resolver
enst
ENSMUST00000120009
resolver
genesymbol
Dnase1
resolver
genesymbol_syn
Dnl1
resolver
uniprot
O70532
resolver
uniprot
Q14BW6
resolver
uniprot_entry
DNAS1_MOUSE
resolver
uniprot_entry
Q14BW6_MOUSE
resolver
uniprot_sec
O70532
resolver
amino_acid_sequence
MRYTGLMGTLLTLVNLLQLAGTLRIAAFNIRTFGETKMSNATLSVYFVKILSRYDIAVIQEVRDSHLVAVGKLLDELNRDKPDTYRYVVSEPLGRKSYKEQYLFVYRPDQVSILDSYQYDDGCEPCGNDTFSREPAIVKFFSPYTEVQEFAIVPLHAAPTEAVSEIDALYDVYLDVWQKWGLEDIMFMGDFNAGCSYVTSSQWSSIRLRTSPIFQWLIPDSADTTVTSTHCAYDRIVVAGALLQAAVVPNSAVPFDFQAEYGLSNQLAEAISDHYPVEVTLRKI
uniprot
proteins
ec_number
3.1.21.1
uniprot
proteins
function
FUNCTION: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:29191910). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (PubMed:29191910). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:29191910). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (PubMed:29191910). {ECO:0000250|UniProtKB:P00639, ECO:0000250|UniProtKB:P21704, ECO:0000250|UniProtKB:P24855, ECO:0000269|PubMed:29191910}.
uniprot
proteins
mass_dalton
32027
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:15015938}.
uniprot
proteins
protein_family
DNase I family
uniprot
proteins
pubmed
10835632
uniprot
proteins
pubmed
15015938
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29191910
uniprot
proteins
pubmed
7857306
uniprot
proteins
pubmed
9192086
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P24855}. Zymogen granule {ECO:0000250|UniProtKB:P24855}. Nucleus envelope {ECO:0000250|UniProtKB:P24855}. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope. {ECO:0000250|UniProtKB:P24855}.
uniprot
proteins