Tmeff1
entrez
230157
canonical
uniprot
Q6PFE7
canonical
ensembl
ENSMUSG00000028347
resolver
ensp
ENSMUSP00000030032
resolver
ensp
ENSMUSP00000121740
resolver
ensp
ENSMUSP00000250506
resolver
genesymbol
Tmeff1
resolver
uniprot
A2AJN3
resolver
uniprot
Q8BRP7
resolver
uniprot
Q8C536
resolver
uniprot
Q9JJS1
resolver
uniprot_entry
TEFF1_MOUSE
resolver
uniprot_sec
A2AJN3
resolver
uniprot_sec
Q8BRP7
resolver
uniprot_sec
Q8C536
resolver
uniprot_sec
Q9JJS1
resolver
amino_acid_sequence
MGAQAPLRLPAAPPLAVCGYTSVLLLFAFCLPGSRASNQPAGGGGDCPGGRGKSNCSELNLRESDIRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKDITVVARGPCYSDNGSGSGEGEEEGSGAGAHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDVSLLGKKDDGLQYRPDVKDAGDEREDVYIGSHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNRGRRQKQNLGHFTSDTSSRMV
uniprot
proteins
function
FUNCTION: Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry (PubMed:39048823). Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent (By similarity). Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane (By similarity). Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors (By similarity). {ECO:0000250|UniProtKB:Q8IYR6, ECO:0000269|PubMed:39048823}.
uniprot
proteins
mass_dalton
40114
uniprot
proteins
protein_family
Tomoregulin family
uniprot
proteins
pubmed
11025219
uniprot
proteins
pubmed
11165370
uniprot
proteins
pubmed
11404089
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
39048823
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:39048823}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 323..343; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins