HDAC9
entrez
9734
canonical
uniprot
Q9UKV0
canonical
ensembl
ENSG00000048052
resolver
ensp
ENSP00000383912
resolver
ensp
ENSP00000384382
resolver
ensp
ENSP00000384657
resolver
ensp
ENSP00000388568
resolver
ensp
ENSP00000395655
resolver
ensp
ENSP00000401669
resolver
ensp
ENSP00000410337
resolver
ensp
ENSP00000430036
resolver
ensp
ENSP00000478829
resolver
ensp
ENSP00000505081
resolver
ensp
ENSP00000506070
resolver
ensp
ENSP00000509161
resolver
ensp
ENSP00000516728
resolver
ensp
ENSP00000675915
resolver
ensp
ENSP00000675916
resolver
ensp
ENSP00000675917
resolver
ensp
ENSP00000675918
resolver
ensp
ENSP00000688830
resolver
ensp
ENSP00000741107
resolver
ensp
ENSP00000741108
resolver
ensp
ENSP00000741109
resolver
enst
ENST00000622668
resolver
enst
ENST00000681273
resolver
enst
ENST00000681950
resolver
enst
ENST00000707077
resolver
genesymbol
HDAC9
resolver
genesymbol_syn
HDAC7
resolver
genesymbol_syn
HDAC7B
resolver
genesymbol_syn
HDRP
resolver
genesymbol_syn
KIAA0744
resolver
genesymbol_syn
MITR
resolver
hgnc
HGNC:14065
resolver
uniprot
A0A087WUQ3
resolver
uniprot
A0A7P0T8F4
resolver
uniprot
A0A7P0TAB5
resolver
uniprot
A0A9L9PXL9
resolver
uniprot
A7E2F3
resolver
uniprot
B7Z3P7
resolver
uniprot
B7Z4I4
resolver
uniprot
B7Z917
resolver
uniprot
B7Z928
resolver
uniprot
B7Z940
resolver
uniprot
C9JS87
resolver
uniprot
E7EX34
resolver
uniprot
F8W9E0
resolver
uniprot
O94845
resolver
uniprot
O95028
resolver
uniprot
Q2M2R6
resolver
uniprot
Q86SL1
resolver
uniprot
Q86US3
resolver
uniprot_entry
A0A087WUQ3_HUMAN
resolver
uniprot_entry
A0A7P0T8F4_HUMAN
resolver
uniprot_entry
A0A7P0TAB5_HUMAN
resolver
uniprot_entry
A0A9L9PXL9_HUMAN
resolver
uniprot_entry
B7Z3P7_HUMAN
resolver
uniprot_entry
HDAC9_HUMAN
resolver
uniprot_sec
A7E2F3
resolver
uniprot_sec
B7Z4I4
resolver
uniprot_sec
B7Z917
resolver
uniprot_sec
B7Z928
resolver
uniprot_sec
B7Z940
resolver
uniprot_sec
C9JS87
resolver
uniprot_sec
E7EX34
resolver
uniprot_sec
F8W9E0
resolver
uniprot_sec
O94845
resolver
uniprot_sec
O95028
resolver
uniprot_sec
Q2M2R6
resolver
uniprot_sec
Q86SL1
resolver
uniprot_sec
Q86US3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Trichostatin A (TSA) and suberoylanilide hydroxamic acid. {ECO:0000269|PubMed:11535832}.
uniprot
proteins
amino_acid_sequence
MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSMSLKFS
uniprot
proteins
disease_involvement
DISEASE: Auriculocondylar syndrome 4 (ARCND4) [MIM:620457]: An autosomal dominant form of auriculocondylar syndrome, a craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. Glossoptosis, masticatory abnormalities, orthodontic problems, and malocclusion occur in a majority of affected subjects. {ECO:0000269|PubMed:34750192}. Note=The disease may be caused by variants affecting the gene represented in this entry.; DISEASE: Note=A chromosomal aberration involving HDAC9 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with TGFB2 resulting in lack of HDAC9 protein. {ECO:0000269|PubMed:12706107}.
uniprot
proteins
ec_number
3.5.1.98
uniprot
proteins
function
FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
uniprot
proteins
mass_dalton
111297
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-220 and Ser-450; which promotes 14-3-3-binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240; which impairs nuclear accumulation (By similarity). Isoform 7 is phosphorylated on Tyr-1010. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. {ECO:0000250, ECO:0000269|PubMed:20188095}.; PTM: Sumoylated. {ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:12590135}.
uniprot
proteins
protein_family
HD type 2 subfamily
uniprot
proteins
protein_family
Histone deacetylase family
uniprot
proteins
pubmed
10487760
uniprot
proteins
pubmed
10487761
uniprot
proteins
pubmed
10523670
uniprot
proteins
pubmed
10655483
uniprot
proteins
pubmed
11535832
uniprot
proteins
pubmed
12032081
uniprot
proteins
pubmed
12590135
uniprot
proteins
pubmed
12706107
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16611996
uniprot
proteins
pubmed
17360565
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20188095
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
34750192
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
1011
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins