CCNA2
entrez
890
canonical
uniprot
P20248
canonical
ensembl
ENSG00000145386
resolver
ensp
ENSP00000274026
resolver
enst
ENST00000274026
resolver
genesymbol
CCNA2
resolver
genesymbol_syn
CCN1
resolver
genesymbol_syn
CCNA
resolver
hgnc
HGNC:1578
resolver
uniprot
A8K7B6
resolver
uniprot
Q2M3U6
resolver
uniprot
Q4W5P4
resolver
uniprot
Q6LER8
resolver
uniprot_entry
CCNA2_HUMAN
resolver
uniprot_sec
A8K7B6
resolver
uniprot_sec
Q2M3U6
resolver
uniprot_sec
Q4W5P4
resolver
uniprot_sec
Q6LER8
resolver
amino_acid_sequence
MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL
uniprot
proteins
function
FUNCTION: Essential for the control of the cell cycle at G1/S and G2/M transition (PubMed:1312467). Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle (PubMed:41100585). {ECO:0000269|PubMed:1312467, ECO:0000269|PubMed:41100585}.
uniprot
proteins
mass_dalton
48551
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome (PubMed:21596315). Deubiquitinated and stabilized by USP37 enables entry into S phase (PubMed:21596315). Ubiquitinated during the G1 phase by the SCF(FBXO31) complex, leading to its proteasomal degradation (PubMed:31413110). {ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:31413110}.
uniprot
proteins
protein_family
Cyclin AB subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
1312467
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17698606
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
1967822
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21540187
uniprot
proteins
pubmed
21596315
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24101496
uniprot
proteins
pubmed
31413110
uniprot
proteins
pubmed
41100585
uniprot
proteins
pubmed
7630397
uniprot
proteins
pubmed
8202514
uniprot
proteins
pubmed
8684460
uniprot
proteins
pubmed
8756328
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1312467, ECO:0000269|PubMed:17698606}. Cytoplasm {ECO:0000269|PubMed:1312467, ECO:0000269|PubMed:17698606}. Note=Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606). {ECO:0000269|PubMed:1312467, ECO:0000269|PubMed:17698606}.
uniprot
proteins