Rbbp5
entrez
213464
canonical
uniprot
Q8BX09
canonical
ensembl
ENSMUSG00000026439
resolver
ensp
ENSMUSP00000027700
resolver
ensp
ENSMUSP00000141003
resolver
ensp
ENSMUSP00000204623
resolver
ensp
ENSMUSP00000330189
resolver
genesymbol
Rbbp5
resolver
uniprot
Q3TBL4
resolver
uniprot
Q3U3G1
resolver
uniprot
Q6PAP0
resolver
uniprot
Q6PFC2
resolver
uniprot_entry
RBBP5_MOUSE
resolver
uniprot_sec
Q3TBL4
resolver
uniprot_sec
Q3U3G1
resolver
uniprot_sec
Q6PAP0
resolver
uniprot_sec
Q6PFC2
resolver
amino_acid_sequence
MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVPSSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSTKGKVQAELSQSLAAGGAISELL
uniprot
proteins
function
FUNCTION: In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (PubMed:21335234). Does not affect ES cell self-renewal (PubMed:21335234). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (By similarity). Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity). {ECO:0000250|UniProtKB:Q15291, ECO:0000269|PubMed:21335234}.
uniprot
proteins
mass_dalton
59098
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21335234
uniprot
proteins
pubmed
23178126
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins