Tdrd1
entrez
83561
canonical
uniprot
Q99MV1
canonical
ensembl
ENSMUSG00000025081
resolver
ensp
ENSMUSP00000077785
resolver
ensp
ENSMUSP00000107231
resolver
ensp
ENSMUSP00000107233
resolver
ensp
ENSMUSP00000112786
resolver
ensp
ENSMUSP00000201710
resolver
ensp
ENSMUSP00000201712
resolver
enst
ENSMUST00000078723
resolver
enst
ENSMUST00000111604
resolver
enst
ENSMUST00000111606
resolver
enst
ENSMUST00000121249
resolver
genesymbol
Tdrd1
resolver
uniprot
A2VDG6
resolver
uniprot
Q6F3G0
resolver
uniprot
Q8CDN7
resolver
uniprot
Q8K1G3
resolver
uniprot_entry
TDRD1_MOUSE
resolver
uniprot_sec
A2VDG6
resolver
uniprot_sec
Q6F3G0
resolver
uniprot_sec
Q8CDN7
resolver
uniprot_sec
Q8K1G3
resolver
amino_acid_sequence
MMPRNNLEASTCKMAEPFNFEKKESKPPPQDPLRSPVAQHNHPTFRLKSPENGNTKNNFLLCEQNKQYLASQEDSSVVSSNPAVVNGEVGGSKGDRKPPPTGNPVSPLSLGNSSPPNQVKTKPSSNVTPEKSKKSHKLFENALSVNNPALFNSLGPPLRSTTCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSSHSTICRPVQQSLNKLEDNKSPFETKAIEVKSEVDCPPGVTKEITAGAERVMFSDLRSLQLKKTMEIKGTVTEFKHPSNFYIQLYSSEVLENMNQLSTSLKETYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAIVQAVDVLQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIPTAGEWSEGCVAAVKALLFEQFCSVKVMDILEEEVLTCAVDLVLQSSGKQLDHVLVEMGYGVKPGEQSSTEQSVDHSALEDVGRVTVESKIVTDRNALIPKVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGIWTPEAVCVMKEMVQNRMVTVRVVGMLGTRALVELIDKSVAPHVSASKALIDSGFAIKEKDVADKGSSMHTASVPLAIEGPAEALEWTWVEFTVDETVDVVVCMMYSPGEFYCHFLKDDALEKLDDLNQSLADYCAQKPPNGFKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPNKHWTKEATARFQACVVGLKLQARVVEITANGVGVELTDLSTPYPKIISDVLIREQLVLRCGSPQDSLMSRPANQHKQIDSHRVQASPSAEQWKTMELPVNKTIAANVLEIISPALFYAIPSEMSENQEKLCVLAAELLEHCNAQKGQPAYRPRTGDACCAKYTNDDFWYRAIVLETSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEGPMELNGSCSQLVMELLRNAMLNQSVVLSVKAISKNVHAVSVEKCSENGMINIAENLVMCGLAENLTSKRKSASTKEIPHSRDCCCTELQKQIEKHEQILLFLLNNPTNQSKFTEMKKLLRS
uniprot
proteins
function
FUNCTION: Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins. {ECO:0000269|PubMed:17038506, ECO:0000269|PubMed:19465913, ECO:0000269|PubMed:19584108}.
uniprot
proteins
mass_dalton
129696
uniprot
proteins
mutagenesis
MUTAGEN 325; /note="N->Y: Strongly enhanced binding to symmetric dimethylarginines."; /evidence="ECO:0000269|PubMed:22996915"; MUTAGEN 774; /note="Y->N: Strongly reduced binding to symmetric dimethylarginines."; /evidence="ECO:0000269|PubMed:22996915"; MUTAGEN 796; /note="N->A: Significantly reduced binding to symmetric dimethylarginines."; /evidence="ECO:0000269|PubMed:22996915"; MUTAGEN 1019; /note="Y->N: Abolishes localization to meiotic nuage; when associated with K-1023."; /evidence="ECO:0000269|PubMed:17141210"; MUTAGEN 1023; /note="E->K: Abolishes localization to meiotic nuage; when associated with N-1019."; /evidence="ECO:0000269|PubMed:17141210
uniprot
proteins
protein_family
TDRD1 family
uniprot
proteins
pubmed
11279525
uniprot
proteins
pubmed
14550528
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16787967
uniprot
proteins
pubmed
17038506
uniprot
proteins
pubmed
17141210
uniprot
proteins
pubmed
19345100
uniprot
proteins
pubmed
19465913
uniprot
proteins
pubmed
19584108
uniprot
proteins
pubmed
20439430
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22996915
uniprot
proteins
pubmed
24067652
uniprot
proteins
sequence_length
1172
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14550528, ECO:0000269|PubMed:17038506, ECO:0000269|PubMed:17141210, ECO:0000269|PubMed:19345100, ECO:0000269|PubMed:19465913, ECO:0000269|PubMed:19584108, ECO:0000269|PubMed:20439430}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (PubMed:20439430). DDX4 is required for meiotic nuage localization. Also present in chromatoid body. {ECO:0000269|PubMed:20439430}.
uniprot
proteins