LDAH
entrez
60526
canonical
uniprot
Q9H6V9
canonical
ensembl
ENSG00000118961
resolver
ensp
ENSP00000237822
resolver
ensp
ENSP00000385951
resolver
ensp
ENSP00000388635
resolver
ensp
ENSP00000400340
resolver
ensp
ENSP00000440570
resolver
ensp
ENSP00000483067
resolver
ensp
ENSP00000487592
resolver
ensp
ENSP00000646882
resolver
enst
ENST00000435420
resolver
enst
ENST00000440866
resolver
genesymbol
FLJ21820
resolver
genesymbol
LDAH
resolver
genesymbol_syn
C2orf43
resolver
hgnc
HGNC:26145
resolver
uniprot
A0A0A0MSH6
resolver
uniprot
A0ACM8QBN3
resolver
uniprot
B4DRG3
resolver
uniprot
B4DS38
resolver
uniprot
B4DWE2
resolver
uniprot
B7ZA47
resolver
uniprot
B7ZAJ5
resolver
uniprot
D6W530
resolver
uniprot
E7EMH0
resolver
uniprot
E7ESN0
resolver
uniprot
Q53T37
resolver
uniprot
Q53T58
resolver
uniprot_entry
A0A0A0MSH6_HUMAN
resolver
uniprot_entry
A0ACM8QBN3_HUMAN
resolver
uniprot_entry
B4DRG3_HUMAN
resolver
uniprot_entry
B4DS38_HUMAN
resolver
uniprot_entry
B4DWE2_HUMAN
resolver
uniprot_entry
LDAH_HUMAN
resolver
uniprot_sec
B7ZA47
resolver
uniprot_sec
B7ZAJ5
resolver
uniprot_sec
D6W530
resolver
uniprot_sec
E7EMH0
resolver
uniprot_sec
E7ESN0
resolver
uniprot_sec
Q53T37
resolver
uniprot_sec
Q53T58
resolver
amino_acid_sequence
MDSELKEEIPVHEEFILCGGAETQVLKCGPWTDLFHDQSVKRPKLLIFIIPGNPGFSAFYVPFAKALYSLTNRRFPVWTISHAGHALAPKDKKILTTSEDSNAQEIKDIYGLNGQIEHKLAFLRTHVPKDMKLVLIGHSIGSYFTLQMLKRVPELPVIRAFLLFPTIERMSESPNGRIATPLLCWFRYVLYVTGYLLLKPCPETIKSLLIRRGLQVMNLENEFSPLNILEPFCLANAAYLGGQEMMEVVKRDDETIKEHLCKLTFYYGTIDPWCPKEYYEDIKKDFPEGDIRLCEKNIPHAFITHFNQEMADMIADSLKDDLSKM
uniprot
proteins
ec_number
3.1.1.13
uniprot
proteins
function
FUNCTION: Probable serine lipid hydrolase associated with lipid droplets (By similarity). Has low cholesterol esterase activity (By similarity). Appears to lack triglyceride lipase activity (By similarity). Involved in cholesterol and triglyceride homeostasis; has opposing effects, stimulating cellular triglyceride accumulation and cellular cholesterol release (PubMed:24357060, PubMed:28578400). Acts antagonistically with PNPLA2/ATGL in regulation of cellular lipid stores (PubMed:28578400). May regulate triglyceride accumulation indirectly through stimulation of PNPLA2/ATGL ubiquitination and proteasomal degradation (PubMed:28578400). Promotes microtubule-dependent lipid droplet fusion (PubMed:28578400). Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages (By similarity). {ECO:0000250|UniProtKB:Q8BVA5, ECO:0000269|PubMed:24357060, ECO:0000269|PubMed:28578400}.
uniprot
proteins
mass_dalton
37319
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
LDAH family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17135363
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24357060
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28578400
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:17135363, ECO:0000269|PubMed:28578400}. Endoplasmic reticulum {ECO:0000269|PubMed:28578400}. Note=Localizes to the endoplasmic reticulum in absence of lipid droplets and translocates to lipid droplets upon lipid storage induction (PubMed:28578400). Lipid droplet localization does not require hydrolase activity (By similarity). {ECO:0000250|UniProtKB:Q8BVA5, ECO:0000269|PubMed:28578400}.
uniprot
proteins