Prune1
entrez
229589
canonical
uniprot
Q8BIW1
canonical
ensembl
ENSMUSG00000015711
resolver
ensp
ENSMUSP00000015855
resolver
enst
ENSMUST00000015855
resolver
genesymbol
Prune1
resolver
genesymbol_syn
Prune
resolver
uniprot
Q80VU0
resolver
uniprot_entry
PRUN1_MOUSE
resolver
uniprot_sec
Q80VU0
resolver
activity_regulation
ACTIVITY REGULATION: Phosphodiesterase activity is activated by magnesium ions and inhibited by manganese ions. Phosphodiesterase activity is inhibited by dipyridamole, moderately sensitive to IBMX and inhibited by vinpocetine. {ECO:0000250|UniProtKB:Q86TP1}.
uniprot
proteins
amino_acid_sequence
MEDYLQDCRAALQDSRPLHVVLGNEACDLDSMVSALALAFYLTKTSEAEDIFIPVLNIKRSELPLRGDNVFFLQEVKIPEPALIFRDEIDLLALHQAGQLTLILVDHHILPKSDAALEEAVAEVLDHRPIEQKYCPPCHVSVELVGSCATLVTERILQGAPETLDRQTAALLHGTIILDCVNMDTNIGKATPKDSKYVEELEALFPDLPKRKDIFDSLQKAKFDVSGLTTEQMLRKDQKTVYRQGTKVAISAIYMDLKAFLQRTDLFTDLSSFCHDHSYDALVAMTIFFNTQNEPVRQLAIFCPHEALRMTICGILERSTSPPLKLTPIPSTSPNLQAYHQGNTQVSRKKLLPVLQEALSAYLDSAKMASGQSEVAVGMSREQVDKDLDKASNSLISGLSQDEEDPPLPPTPMNSLVDECPLDQGLPKFSAEAVFEKCSQISLSQSARACTSNK
uniprot
proteins
ec_number
3.6.1.14
uniprot
proteins
ec_number
3.6.1.25
uniprot
proteins
function
FUNCTION: Exopolyphosphatase that catalyzes the hydrolysis of inorganic polyphosphates, with preference for short-chain substrates, as well as nucleoside 5'-tetraphosphates, releasing terminal phosphate residues. Also exhibits phosphodiesterase activity toward cyclic nucleotides, hydrolyzing cAMP and cGMP to their corresponding 5'-monophosphates. Requires divalent metal ions for activity. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization. {ECO:0000250|UniProtKB:Q86TP1}.
uniprot
proteins
mass_dalton
50239
uniprot
proteins
protein_family
PPase class C family
uniprot
proteins
protein_family
Prune subfamily
uniprot
proteins
pubmed
10602478
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
454
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}.
uniprot
proteins