Dnajc10
entrez
66861
canonical
uniprot
Q9DC23
canonical
ensembl
ENSMUSG00000027006
resolver
ensp
ENSMUSP00000028392
resolver
enst
ENSMUST00000028392
resolver
genesymbol
Dnajc10
resolver
genesymbol_syn
Erdj5
resolver
genesymbol_syn
Jpdi
resolver
uniprot
A2ASA2
resolver
uniprot
Q71S84
resolver
uniprot
Q8CH78
resolver
uniprot
Q8CIB0
resolver
uniprot
Q99LV4
resolver
uniprot
Q9CUG0
resolver
uniprot_entry
DJC10_MOUSE
resolver
uniprot_entry
Q9CUG0_MOUSE
resolver
uniprot_sec
A2ASA2
resolver
uniprot_sec
Q71S84
resolver
uniprot_sec
Q8CH78
resolver
uniprot_sec
Q8CIB0
resolver
uniprot_sec
Q99LV4
resolver
amino_acid_sequence
MGVWLNKDDFIRDLKRISLCLLILYVVVVVGTDQNFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHGDFLKINRAYEVLKDEDLRKKYDKYGEKGLEDNQGGQYESWSYYRYDFGIYDDDPEIITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWREFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYNGDRSKESLVAFAMQHVRSTVTELSTGNFVNAIETAFAAGVGWLITFCSKGEDCLTSQTRLRLSGMLDGLVNVGWVDCDAQDSLCKSLDTTASTTAYFPPGATLNDREKSSVLFLNSLDAKEIYMEIIHNLPDFELLSANQLEDRLAHHRWLVFFHFGKNENANDPELKKLKTLLKNEHIQVGRFDCSSAPGICSDLYVFQPCLAVFKGQGTKEYEIHHGKKILYDILAFAKESVNSHVTTLGPQNFPASDKEPWLVDFFAPWCPPCRALLPELRKASTLLYGQLKVGTLDCTIHEGLCNMYNIQAYPTTVVFNQSSIHEYEGHHSAEQILEFIEDLRNPSVVSLTPSTFNELVKQRKHDEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSVDCQQYHSFCTQENVQRYPEIRFYPQKSSKAYQYHSYNGWNRDAYSLRSWGLGFLPQASIDLTPQTFNEKVLQGKTHWVVDFYAPWCGPCQNFAPEFELLARMIKGKVRAGKVDCQAYPQTCQKAGIKAYPSVKLYQYERAKKSIWEEQINSRDAKTIAALIYGKLETLQSQVKRNKDEL
uniprot
proteins
ec_number
1.8.4.2
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum disulfide reductase that collaborates directly with the chaperone BIP/HSPA5 (GRP78) to maintain protein quality control by facilitating either the correct folding or the targeted degradation of misfolded proteins (PubMed:12411443, PubMed:12446677, PubMed:18653895, PubMed:21329881). Essential for efficient maturation of newly synthesized polypeptides in the endoplasmic reticulum, binds to substrate proteins and specifically catalyzes the reduction and removal of improper (non-native) disulfide bonds during the folding process (By similarity). In endoplasmic reticulum-associated degradation (ERAD), DNAJC10 reduces incorrect disulfide bonds specifically in misfolded glycoproteins that have been recognized by EDEM1, a key component of the ERAD pathway, thereby enabling their retrotranslocation and degradation (PubMed:18653895, PubMed:21329881). Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress (By similarity). {ECO:0000250|UniProtKB:Q8IXB1, ECO:0000269|PubMed:12411443, ECO:0000269|PubMed:12446677, ECO:0000269|PubMed:18653895, ECO:0000269|PubMed:21329881}.
uniprot
proteins
mass_dalton
90583
uniprot
proteins
mutagenesis
MUTAGEN 158; /note="C->A: Abolishes disulfide reductase activity; when associated with A-161; A-480; A-483; A-588; A-591; A-700 and A-703."; /evidence="ECO:0000269|PubMed:18653895, ECO:0000269|PubMed:21329881"; MUTAGEN 161; /note="C->A: Abolishes disulfide reductase activity; when associated with A-158; A-480; A-483; A-588; A-591; A-700 and A-703."; /evidence="ECO:0000269|PubMed:18653895, ECO:0000269|PubMed:21329881"; MUTAGEN 480; /note="C->A: Abolishes disulfide reductase activity; when associated with A-158; A-161; A-483; A-588; A-591; A-700 and A-703."; /evidence="ECO:0000269|PubMed:18653895, ECO:0000269|PubMed:21329881"; MUTAGEN 483; /note="C->A: Abolishes disulfide reductase activity; when associated with A-158; A-161; A-480; A-588; A-591; A-700 and A-703."; /evidence="ECO:0000269|PubMed:18653895, ECO:0000269|PubMed:21329881"; MUTAGEN 588; /note="C->A: Abolishes disulfide reductase activity; when associated with A-158; A-161; A-480; A-483; A-591; A-700 and A-703."; /evidence="ECO:0000269|PubMed:18653895, ECO:0000269|PubMed:21329881"; MUTAGEN 591; /note="C->A: Abolishes disulfide reductase activity; when associated with A-158; A-161; A-480; A-483; A-588; A-700 and A-703."; /evidence="ECO:0000269|PubMed:18653895, ECO:0000269|PubMed:21329881"; MUTAGEN 700; /note="C->A: Abolishes disulfide reductase activity; when associated with A-158; A-161; A-480; A-483; A-588; A-591 and A-703."; /evidence="ECO:0000269|PubMed:18653895, ECO:0000269|PubMed:21329881"; MUTAGEN 703; /note="C->A: Abolishes disulfide reductase activity; when associated with A-158; A-161; A-480; A-483; A-588; A-591 and A-700."; /evidence="ECO:0000269|PubMed:18653895, ECO:0000269|PubMed:21329881
uniprot
proteins
pubmed
12411443
uniprot
proteins
pubmed
12446677
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18653895
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19788412
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21329881
uniprot
proteins
sequence_length
793
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12446677}.
uniprot
proteins