Apeh
entrez
24206
canonical
uniprot
P13676
canonical
ensembl
ENSRNOG00000029572
resolver
ensp
ENSRNOP00000043843
resolver
genesymbol
Apeh
resolver
uniprot
B2GVB7
resolver
uniprot
P14320
resolver
uniprot
P70479
resolver
uniprot_entry
ACPH_RAT
resolver
uniprot_entry
B2GVB7_RAT
resolver
uniprot_sec
P14320
resolver
uniprot_sec
P70479
resolver
activity_regulation
ACTIVITY REGULATION: Homotetramerization is required for activity. Tetramerization results in the formation of a gated channel which is involved in substrate selection and substrate access to the catalytic sites. {ECO:0000250|UniProtKB:P19205}.
uniprot
proteins
amino_acid_sequence
MERQVLLSEPQEAAALYRGLSRQPSLSAACLGPEVTTQYGGLYRTVHTEWTQRDLERMENIRFCRQYLVFHDGDSVVFAGPAGNSVETRGELLSRESPSGTMKAVLRKAGGTVSGEEKQFLEVWEKNRKLKSFNLSALEKHGPVYEDDCFGCLSWSHSETHLLYVAEKKRPKAESFFQTKALDISASDDEMARPKKPDQAIKGDQFVFYEDWGETMVSKSIPVLCVLDIDSGNISVLEGVPENVSPGQAFWAPGDTGVVFVGWWHEPFRLGIRYCTNRRSALYYVDLSGGKCELLSDGSLAICSPRLSPDQCRIVYLQYPCLAPHHQCSQLCLYDWYTKVTSVVVDIVPRQLGESFSGIYCSLLPLGCWSADSQRVVFDSAQRSRQDLFAVDTQTGSITSLTAAGSAGSWKLLTIDKDLMVAQFSTPSLPPSLKVGFLPPPGKEQSVSWVSLEEAEPIPGIHWGVRVLHPPPDQENVQYADLDFEAILLQPSNPPDKTQVPMVVMPHGGPHSSFVTAWMLFPAMLCKMGFAVLLVNYRGSTGFGQDSILSLPGNVGHQDVKDVQFAVEQVLQEEHFDARRVALMGGSHGGFLSCHLIGQYPETYSACIARNPVINIASMMGSTDIPDWCMVETGFPYSNSCLPDLNVWEEMLDKSPIKYIPQVKTPVLLMLGQEDRRVPFKQGMEYYRALKARNVPVRLLLYPKSNHALSEVEAESDSFMNAVLWLHTHLGS
uniprot
proteins
ec_number
3.4.19.1
uniprot
proteins
function
FUNCTION: Aminopeptidase involved in the degradation of N(alpha)-acylated peptides. Displays exopeptidase activity toward N-formyl and N-acetyl peptides with a preference for dipeptide substrates (PubMed:15938642, PubMed:3305492). Catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (PubMed:3305492). It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (PubMed:3305492). Hydrolyzes N-formylated peptides arising from N-terminal proteolytic cleavage of bacterial and mitochondrial proteins (PubMed:15938642). May act sequentially with ACY1 in the degradation of N-acylated peptides: APEH first cleaves N-acylaminoacids from N-acylated peptides, then ACY1 further hydrolyzes the N-acylaminoacid into free aminoacid and a carboxylate (PubMed:15938642). Displays endopeptidase activity involved in the degradation of oxidized and glycated proteins (By similarity). {ECO:0000250|UniProtKB:P13798, ECO:0000269|PubMed:15938642, ECO:0000269|PubMed:3305492}.
uniprot
proteins
mass_dalton
81384
uniprot
proteins
protein_family
Peptidase S9C family
uniprot
proteins
pubmed
15938642
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2578023
uniprot
proteins
pubmed
2722805
uniprot
proteins
pubmed
3305492
uniprot
proteins
sequence_length
732
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P13798}.
uniprot
proteins