Mrgprx1
entrez
282547
canonical
uniprot
Q8R4G1
canonical
ensembl
ENSRNOG00000014242
resolver
ensembl
ENSRNOG00065009144
resolver
ensp
ENSRNOP00000019061
resolver
ensp
ENSRNOP00065010928
resolver
enst
ENSRNOT00000019061
resolver
enst
ENSRNOT00065014599
resolver
genesymbol
Mrgprx1
resolver
genesymbol_syn
Mrgc
resolver
genesymbol_syn
Mrgprc
resolver
genesymbol_syn
Mrgprc11
resolver
genesymbol_syn
Mrgprx4
resolver
genesymbol_syn
Snsr
resolver
genesymbol_syn
Snsr1
resolver
uniprot
Q7TN42
resolver
uniprot
W8W3G5
resolver
uniprot_entry
MRGX1_RAT
resolver
uniprot_entry
W8W3G5_RAT
resolver
uniprot_sec
Q7TN42
resolver
amino_acid_sequence
MDPTISSLSTESTTLNKTGHPSCRPILTLSFLVPIITLLGLAGNTIVLWLLGFRMRRKAISVYVLNLSLADSFFLCCHFIDSLMRIMNFYGIYAHKLSKEILGNAAIIPYISGLSILSAISTERCLSVLWPIWYHCHRPRNMSAIICVLIWVLSFLMGILDWFFSGFLGETHHHLWKNVDFIVTAFLIFLFMLLFGSSLALLVRILCGSRRKPLSRLYVTISLTVMVYLICGLPLGLYLFLLYWFGIHLHYPFCHIYQVTVLLSCVNSSANPIIYFLVGSFRHRKKHRSLKMVLKRALEETPEEDEYTDSHVQKPTEISERRC
uniprot
proteins
function
FUNCTION: G protein-coupled receptor specifically expressed in sensory neurons of dorsal root ganglion, and which is involved in itch perception and pain transmission. Specifically activated by a variety of enkephalin (PENK) neuropeptides, such as BAM22 and BAM8-22, which induce itch in a histamine-independent manner. Activated by some tick defensins, such as I.persulcatus Def1 and I.ricinus Def2, evoking itch. Also activated following cleavage by the dust mite cysteine protease Der p1. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. MRGPRX1 is both coupled to G(q) and G(i) G proteins: G(q) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, leading to sensitize TRPV1 in pruriceptors, while G(i) coupling mediates inhibition of adenylate cyclase activity. Activation of MRGPRX1 in the peripheral nervous system elicits itch, evoking scratching (By similarity). MRGPRX1 activation in sensory neurons of the nasal mucosa mediates sneezing responses to irritants or influenza-virus (By similarity). Activation in the central nervous system dampens chronic pain: BAM8-22-binding at the central terminals prevents pain signals passing to spinal cord neurons, attenuating spinal nociceptive transmission (By similarity). Activation by CXCL17 induces chemotactic movement (By similarity). {ECO:0000250|UniProtKB:Q8CIP3, ECO:0000250|UniProtKB:Q96LB2}.
uniprot
proteins
mass_dalton
37074
uniprot
proteins
post_translational_modification
PTM: Cleavage by D.pteronyssinus cysteine protease Der p1 leads to activation. {ECO:0000250|UniProtKB:Q96LB2}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Mas subfamily
uniprot
proteins
pubmed
11850634
uniprot
proteins
pubmed
12909716
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96LB2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96LB2}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..52; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q96LB2"; TRANSMEM 60..86; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q96LB2"; TRANSMEM 97..126; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q96LB2"; TRANSMEM 142..169; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q96LB2"; TRANSMEM 176..203; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q96LB2"; TRANSMEM 217..243; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q96LB2"; TRANSMEM 254..278; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q96LB2
uniprot
proteins