SLC51B
entrez
123264
canonical
uniprot
Q86UW2
canonical
ensembl
ENSG00000186198
resolver
ensp
ENSP00000335292
resolver
ensp
ENSP00000556713
resolver
ensp
ENSP00000556714
resolver
enst
ENST00000334287
resolver
enst
ENST00000886654
resolver
enst
ENST00000886655
resolver
genesymbol
SLC51B
resolver
genesymbol_syn
OSTB
resolver
hgnc
HGNC:29956
resolver
uniprot
Q3SYF5
resolver
uniprot_entry
OSTB_HUMAN
resolver
uniprot_sec
Q3SYF5
resolver
amino_acid_sequence
MEHSEGAPGDPAGTVVPQELLEEMLWFFRVEDASPWNHSILALAAVVVIISMVLLGRSIQASRKEKMQPPEKETPEVLHLDEAKDHNSLNNLRETLLSEKPNLAQVELELKERDVLSVFLPDVPETES
uniprot
proteins
disease_involvement
DISEASE: Bile acid malabsorption, primary, 2 (PBAM2) [MIM:619481]: An autosomal recessive disorder characterized by chronic diarrhea, severe fat-soluble vitamin deficiency, and features of cholestatic liver disease. {ECO:0000269|PubMed:28898457}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Essential component of the OST-alpha/OST-beta complex, a heterotetramer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:16317684, PubMed:41606314, PubMed:41606328). The OST-alpha/OST-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684, PubMed:41606314, PubMed:41606328). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). In the complex, SLC51B/OST-beta promotes the transmembrane translocation of bile acids (PubMed:41606314, PubMed:41606328). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (PubMed:16317684). Able to transport eicosanoids such as prostaglandin E2 (By similarity). {ECO:0000250|UniProtKB:Q80WK2, ECO:0000250|UniProtKB:Q90YM4, ECO:0000269|PubMed:16317684, ECO:0000269|PubMed:41606314, ECO:0000269|PubMed:41606328}.
uniprot
proteins
mass_dalton
14346
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="W->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606314
uniprot
proteins
protein_family
OST-beta family
uniprot
proteins
pubmed
12719432
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16251721
uniprot
proteins
pubmed
16269519
uniprot
proteins
pubmed
16317684
uniprot
proteins
pubmed
28898457
uniprot
proteins
pubmed
41606314
uniprot
proteins
pubmed
41606328
uniprot
proteins
sequence_length
128
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12719432, ECO:0000269|PubMed:16317684}; Single-pass membrane protein {ECO:0000269|PubMed:41606314, ECO:0000269|PubMed:41606328}. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes. {ECO:0000269|PubMed:16317684}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..62; /note="Helical; Name=TM0"; /evidence="ECO:0000269|PubMed:41606328, ECO:0007744|PDB:9UNV, ECO:0007744|PDB:9UO1, ECO:0007744|PDB:9UO2
uniprot
proteins