Orc3
entrez
313138
canonical
uniprot
Q4R180
canonical
ensembl
ENSRNOG00000008314
resolver
ensp
ENSRNOP00000011085
resolver
genesymbol
Orc3
resolver
genesymbol_syn
Orc3l
resolver
uniprot_entry
ORC3_RAT
resolver
amino_acid_sequence
MATSSVSKGCFVFKPDFKKRKISVPIEDYFNNEELDSEDSKLRFETYRLLWQRIKSETEQLQEGLNENLFDNLVDFLQKSHSEFQKNSGNWGSQMRLREIPTAALILGVNVTDHDVIFRSLTETLHNNVTPYVVSLQAKDCPDVKHFLQKLTSELIDCCVDRNSKEEKNDKALRRTSYSMDSLSSWYSTVAQKTGPKMTSKKRATCSQWQSPPVVLILKNMESFSTKVLQDFIIISSQHLHEFPLILIFGIATSPVIIHRLLPHSVSSLLCIELFQSLSCKEHLTVVLDKLLLTPQFPFKLSKKALQVLTNIFLYHDFSIQNFIKGLKLSLLEHFYSQPLSVLCCDLSEAKKRINVFSVNQCEKIRRLPSFRRYVENQPLEKQVALLTNETFLKEETQSLLEDLHVYHINYFLVLRCLHNFTSSLPKYPLGRQIRELYCTCLEKKIWDSEEYESALQLLRMLAKDELMGILEQCVKVLNSSTEKQLSNTAQKIKGFLTQFQNLDDSKEEEDACGSQPKGLQKTDLYHLQKSLLEMKELRRTTKKPTKFEMLRENVINFIDNLVRDYLLPPEGQPLHEVVYFSAANTLREHLNAAPRIALHTALNNPYYYLKNEALKSEEGCIPSVAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDTNSTVSEEMSEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTWGGC
uniprot
proteins
function
FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000250|UniProtKB:Q9UBD5}.
uniprot
proteins
mass_dalton
81901
uniprot
proteins
post_translational_modification
PTM: Multi-mono-ubiquitinated by OBI1; ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle. {ECO:0000250|UniProtKB:Q9UBD5}.
uniprot
proteins
protein_family
ORC3 family
uniprot
proteins
sequence_length
711
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UBD5}. Chromosome {ECO:0000250|UniProtKB:Q9UBD5}.
uniprot
proteins