Rcc1
entrez
100088
canonical
uniprot
Q8VE37
canonical
ensembl
ENSMUSG00000028896
resolver
ensp
ENSMUSP00000030726
resolver
ensp
ENSMUSP00000081271
resolver
ensp
ENSMUSP00000101571
resolver
enst
ENSMUST00000030726
resolver
enst
ENSMUST00000084250
resolver
enst
ENSMUST00000105951
resolver
genesymbol
Rcc1
resolver
genesymbol_syn
Chc1
resolver
uniprot
F8WGP9
resolver
uniprot
Q3U6D2
resolver
uniprot
Q3UDB6
resolver
uniprot
Q6PFB2
resolver
uniprot_entry
F8WGP9_MOUSE
resolver
uniprot_entry
Q3U6D2_MOUSE
resolver
uniprot_entry
Q6PFB2_MOUSE
resolver
uniprot_entry
RCC1_MOUSE
resolver
uniprot_sec
Q3UDB6
resolver
amino_acid_sequence
MPPKRIAKRRSPPEDAIPKSKKVKVSHRSHNTEPGLVLTLGQGDVGQLGLGESVLERKKPALVPLLQDVVQAEAGGMHTVCLSQSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDAPVVKVASGNDHLVMLTNDGDLYTLGCGEQGQLGRVPELFANRGGRQGLGRLLVPRCVLLKSRGTRGRVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLGTPGTGSCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPVVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTGKQLENRVVLTVSSGGQHTVLLVKDQAQS
uniprot
proteins
function
FUNCTION: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. {ECO:0000250|UniProtKB:P18754}.
uniprot
proteins
mass_dalton
44931
uniprot
proteins
post_translational_modification
PTM: N-terminal methylation by METTL11A/NTM1 is required for binding double-stranded DNA and stable chromatin association. Dimethylation produces a permanent positive charge on the amino group, which facilitates electrostatic binding to the phosphate groups on DNA, while inhibiting histone-binding. Methylated tail helps retain RCC1 on chromosomes during nucleotide exchange on Ran. {ECO:0000250|UniProtKB:P18754}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20668449
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P18754}. Chromosome {ECO:0000250|UniProtKB:P18754}. Cytoplasm {ECO:0000250|UniProtKB:P18754}. Note=Predominantly nuclear in interphase cells. Binds to mitotic chromosomes. {ECO:0000250|UniProtKB:P18754}.
uniprot
proteins