IL25
entrez
64806
canonical
uniprot
Q9H293
canonical
ensembl
ENSG00000166090
resolver
ensp
ENSP00000328111
resolver
ensp
ENSP00000380417
resolver
genesymbol
IL25
resolver
genesymbol_syn
IL17E
resolver
hgnc
HGNC:13765
resolver
uniprot
Q2M3F0
resolver
uniprot
Q8IZV3
resolver
uniprot
Q8WXB0
resolver
uniprot_entry
IL25_HUMAN
resolver
uniprot_sec
Q2M3F0
resolver
uniprot_sec
Q8IZV3
resolver
uniprot_sec
Q8WXB0
resolver
amino_acid_sequence
MRERPRLGEDSSLISLFLQVVAFLAMVMGTHTYSHWPSCCPSKGQDTSEELLRWSTVPVPPLEPARPNRHPESCRASEDGPLNSRAISPWRYELDRDLNRLPQDLYHARCLCPHCVSLQTGSHMDPRGNSELLYHNQTVFYRRPCHGEKGTHKGYCLERRLYRVSLACVCVRPRVMG
uniprot
proteins
function
FUNCTION: Cytokine produced by various cells such as eosinophils, T-helper type 2 (Th2) cells or epithelial cells that plays a role in internal safety of adaptive immune responses by regulating cytokine production (PubMed:15860795, PubMed:25821217). Promotes and augments T-helper type 2 responses locally or systemically (PubMed:25821217). Exerts its activity via its receptor composed of IL17RA and IL17RB for signal transduction (By similarity). In turn, stimulates the JAK2-STAT5A pathway and promotes the secretion of type-2 associated cytokines including IL4, IL9 and IL13 (PubMed:25821217). Also induces the release of IL8, and IL6 from eosinophils through the combined activation of MAPK and NF-kappa-B pathways (PubMed:15860795). Inhibits the differentiation of T-helper (Th17) cells via the production of IL4, IL5 and IL13 (PubMed:11754819). {ECO:0000250|UniProtKB:Q8VHH8, ECO:0000269|PubMed:11754819, ECO:0000269|PubMed:15860795, ECO:0000269|PubMed:25821217}.
uniprot
proteins
mass_dalton
20330
uniprot
proteins
protein_family
IL-17 family
uniprot
proteins
pubmed
11058597
uniprot
proteins
pubmed
11754819
uniprot
proteins
pubmed
12239140
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15860795
uniprot
proteins
pubmed
25821217
uniprot
proteins
sequence_length
177
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins