Irf9
entrez
16391
canonical
uniprot
Q61179
canonical
ensembl
ENSMUSG00000002325
resolver
ensp
ENSMUSP00000119477
resolver
ensp
ENSMUSP00000120359
resolver
ensp
ENSMUSP00000120525
resolver
enst
ENSMUST00000130697
resolver
enst
ENSMUST00000134863
resolver
enst
ENSMUST00000138037
resolver
genesymbol
Irf9
resolver
genesymbol_syn
Isgf3g
resolver
uniprot
E9PZJ2
resolver
uniprot
E9Q8M6
resolver
uniprot
Q3UKQ7
resolver
uniprot_entry
E9PZJ2_MOUSE
resolver
uniprot_entry
E9Q8M6_MOUSE
resolver
uniprot_entry
IRF9_MOUSE
resolver
uniprot_entry
Q3UKQ7_MOUSE
resolver
amino_acid_sequence
MASGKVRCTRKLRSWIVEQVESGHFPGVCWDDAAKTMFRIPWKHAGKQDFREDQDAAIFKAWALFKEKHKDGDIGHPAVWKTRLRCALNKSSEFEEVPERGRMDVAEPYKVYRILPAGTLPNQPRNQKSPCKRSISCVSPEREENMENGRTNGVVNHSDSGSNIGGGGNGSNRSDSNSNCNSELEEGAGTTEATIREDPVFLEHQLPLNSDYSLLLTFIYGGRVVGKTQVHSLDCRLVAERSDSESSMEQVEFPKPDPLEPTQHLLNQLDRGVLVASNSRGLFVQRLCPIPISWNAPEAPPGPGPHLLPSNKCVELFKTTYFCRDLAQYFQGQGPPPKFQATLHFWEESPGSSHSQENLITVQMEQAFARHLLEKIPEEEKAALFLLQHTEQSPSALGH
uniprot
proteins
function
FUNCTION: Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. {ECO:0000250|UniProtKB:Q00978}.
uniprot
proteins
mass_dalton
44610
uniprot
proteins
protein_family
IRF family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17332413
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7843405
uniprot
proteins
pubmed
8882710
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins