Dixdc1
entrez
363062
canonical
uniprot
Q2VUH7
canonical
ensembl
ENSRNOG00000010260
resolver
ensp
ENSRNOP00000037500
resolver
ensp
ENSRNOP00000073690
resolver
ensp
ENSRNOP00000085938
resolver
enst
ENSRNOT00000083102
resolver
enst
ENSRNOT00000100212
resolver
genesymbol
Dixdc1
resolver
genesymbol_syn
Ccd1
resolver
uniprot
A0A0G2K662
resolver
uniprot
A0A8I6A4R3
resolver
uniprot_entry
A0A0G2K662_RAT
resolver
uniprot_entry
A0A8I6A4R3_RAT
resolver
uniprot_entry
DIXC1_RAT
resolver
amino_acid_sequence
MLACLTRGNLLDVLQEGFNEQQLQAYVAWVNAQLKKRPSVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQLSPSNQQEMKSNVERVLQFVASKNIRMHQTSAKDIVEGNLKSIMRLVLALAAHFKPGSSRTVSQGRDSRTSVQSHQPHCATAVAQGAAAALADVCHDVSRSGRDVFRYRQRNASVDEEIENPYWSVRALVQQYEGQQRSPSESSCSSLTSPSPIHSAKSESIITQSEEKADFVIIPSEGIENRTDETGSPLSRDWRPGSPGTYLEATWEEQLLEQQEHLEKEMEEAKKMISGLQALLLNGSLPEDEQERPVALCEPGVNPEEQLIIIRSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKDLGQKDRLLQQQQAKLEDALRKLSDASYQQVDLERELEQKDVLLAHRVKGDTDEVTNYNSHSSQRNGFVLPVAGRAATTATHRGPQSSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLIERLHVIETQKKQERKVRGRSPRNQASSEYRASWPPNSTLPHSQSSPAVSNTCTKVLYFTDRSLTPFMVNIPKRLGEVTLKDFKAAIDREGSHRYHFKALDPEFGTVKEEVFHDDDAIPGWEGKIVAWVEDHREN
uniprot
proteins
function
FUNCTION: Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. {ECO:0000250|UniProtKB:Q155Q3}.
uniprot
proteins
mass_dalton
77303
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine and serine residues. {ECO:0000250|UniProtKB:Q155Q3}.; PTM: Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation (By similarity). {ECO:0000250|UniProtKB:Q155Q3}.
uniprot
proteins
protein_family
DIXDC1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
684
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q155Q3}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q155Q3}. Cytoplasm {ECO:0000250|UniProtKB:Q155Q3}. Note=Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis. Associated with actin stress fiber at the filament ends. {ECO:0000250|UniProtKB:Q155Q3}.
uniprot
proteins