TINCR
entrez
257000
canonical
uniprot
A0A2R8Y7D0
canonical
ensembl
ENSG00000223573
resolver
ensp
ENSP00000489810
resolver
ensp
ENSP00000490584
resolver
ensp
ENSP00000496189
resolver
enst
ENST00000448587
resolver
enst
ENST00000587632
resolver
enst
ENST00000646160
resolver
genesymbol
TINCR
resolver
genesymbol_syn
LINC00036
resolver
genesymbol_syn
NCRNA00036
resolver
genesymbol_syn
PLAC2
resolver
hgnc
HGNC:14607
resolver
uniprot
A0A1B0GTR7
resolver
uniprot
A0A1B0GVN0
resolver
uniprot_entry
TINCR_HUMAN
resolver
uniprot_sec
A0A1B0GTR7
resolver
uniprot_sec
A0A1B0GVN0
resolver
amino_acid_sequence
MEGLRRGLSRWKRYHIKVHLADEALLLPLTVRPRDTLSDLRAQLVGQGVSSWKRAFYYNARRLDDHQTVRDARLQDGSVLLLVSDPR
uniprot
proteins
function
FUNCTION: Promotes epithelial differentiation by enhancing the sumoylation and activation of CDC42 (PubMed:36369429). Promotes keratinocyte proliferation (PubMed:32012357). This contributes to the maintenance of skin homeostasis by enhancing wound healing after skin injury (By similarity). Acts as a tumor suppressor in epithelial tumors (PubMed:36369429, PubMed:36899004). {ECO:0000250|UniProtKB:A0A1B0GRQ3, ECO:0000269|PubMed:32012357, ECO:0000269|PubMed:36369429, ECO:0000269|PubMed:36899004}.
uniprot
proteins
mass_dalton
10124
uniprot
proteins
mutagenesis
MUTAGEN 79..82; /note="VLLL->AAAA: Abolishes interaction with SUMO1, SUMO2 and CDC42. Reduces protein stability."; /evidence="ECO:0000269|PubMed:36369429
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
32012357
uniprot
proteins
pubmed
34351912
uniprot
proteins
pubmed
36369429
uniprot
proteins
pubmed
36899004
uniprot
proteins
sequence_length
87
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:36369429}. Cell junction {ECO:0000269|PubMed:36369429}. Cytoplasm {ECO:0000250|UniProtKB:A0A1B0GRQ3}.
uniprot
proteins