Chia
entrez
81600
canonical
uniprot
Q91XA9
canonical
ensembl
ENSMUSG00000062778
resolver
ensp
ENSMUSP00000078134
resolver
enst
ENSMUST00000079132
resolver
genesymbol
Chia
resolver
genesymbol_syn
Chia1
resolver
uniprot
A0T468
resolver
uniprot
B8K282
resolver
uniprot
Q3TVE7
resolver
uniprot
Q99PH2
resolver
uniprot
Q9D803
resolver
uniprot
Q9JLN1
resolver
uniprot_entry
CHIA_MOUSE
resolver
uniprot_sec
A0T468
resolver
uniprot_sec
B8K282
resolver
uniprot_sec
Q3TVE7
resolver
uniprot_sec
Q99PH2
resolver
uniprot_sec
Q9D803
resolver
uniprot_sec
Q9JLN1
resolver
amino_acid_sequence
MAKLLLVTGLALLLNAQLGSAYNLICYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQNNEITTIEWNDVTLYKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVKEMREAFEQEAIESNRPRLMVTAAVAGGISNIQAGYEIPELSKYLDFIHVMTYDLHGSWEGYTGENSPLYKYPTETGSNAYLNVDYVMNYWKNNGAPAEKLIVGFPEYGHTFILRNPSDNGIGAPTSGDGPAGPYTRQAGFWAYYEICTFLRSGATEVWDASQEVPYAYKANEWLGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPLTSTLNKALGISTEGCTAPDVPSEPVTTPPGSGSGGGSSGGSSGGSGFCADKADGLYPVADDRNAFWQCINGITYQQHCQAGLVFDTSCNCCNWP
uniprot
proteins
ec_number
3.2.1.14
uniprot
proteins
function
FUNCTION: Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. Presence in saliva and gastric juice suggests a function as a digestive enzyme. {ECO:0000269|PubMed:11085997, ECO:0000269|PubMed:12133911, ECO:0000269|PubMed:15192232, ECO:0000269|PubMed:19076793}.
uniprot
proteins
mass_dalton
52003
uniprot
proteins
mutagenesis
MUTAGEN 208; /note="H->N: Strongly reduced activity at low pH, with minor effect on activity at neutral pH."; /evidence="ECO:0000269|PubMed:18294964
uniprot
proteins
protein_family
Chitinase class II subfamily
uniprot
proteins
protein_family
Glycosyl hydrolase 18 family
uniprot
proteins
pubmed
11085997
uniprot
proteins
pubmed
12133911
uniprot
proteins
pubmed
12971947
uniprot
proteins
pubmed
15192232
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18294964
uniprot
proteins
pubmed
18824549
uniprot
proteins
pubmed
19076793
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
473
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted. Cytoplasm. Cytoplasmic granule. Note=Detected in secretory granules of parotid acinar cells and gastric chief cells and secreted from them into saliva and gastric juice, respectively.
uniprot
proteins