Tmem175
entrez
305623
canonical
uniprot
Q6AY05
canonical
ensembl
ENSRNOG00000000044
resolver
ensembl
ENSRNOG00055026816
resolver
ensembl
ENSRNOG00060011308
resolver
ensembl
ENSRNOG00065012230
resolver
ensp
ENSRNOP00000000050
resolver
ensp
ENSRNOP00055038028
resolver
ensp
ENSRNOP00060014946
resolver
ensp
ENSRNOP00065015231
resolver
enst
ENSRNOT00000000050
resolver
enst
ENSRNOT00055046361
resolver
enst
ENSRNOT00060019125
resolver
enst
ENSRNOT00065019881
resolver
genesymbol
Tmem175
resolver
uniprot_entry
TM175_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Active at low pH (under pH 4.6): proton channel activity is activated by luminal side protons. Polyunsaturated fatty acids, such as arachidonic acid, also activate the channel activity. Proton channel activity is directly inhibited by LAMP1 or LAMP2, facilitating lysosomal acidification. Channel activity is activated following interaction with AKT (AKT1, AKT2 or AKT3): interaction promotes activation from closed to an open state. Activation by AKT is independent of AKT serine/threonine-protein kinase activity. {ECO:0000250|UniProtKB:Q9BSA9}.
uniprot
proteins
amino_acid_sequence
MSRLQVQEQAVDSEGDSSLYRRDEEGTQSSHRMLGFSDALLSIIATVMILPVTHTEISPEQQFDKSIQKLLATRIAVYLMTFLIVTVAWAAHTRLFQVVGKIDDTLALLNLACMMTITLLPYTFSLMVTFPDVPLGIFLFCMCVIAIGSVQAMIVGYAFHFPHLLNPQIQCSTHRALSRRHILHLVLRGPALCFVAAVFSLFFFPLSYLLMVTVIFLPHISKATTWCKDKFMGHRESPAHNVEPFSIDLHAPLSKERVEAFSDGVYAIVATLLILDICEDNVPDPKDVQQKFSGSLVAALGAYGPQFLAYFGSFATVGLLWFAHHSLFLHVRKATQTMGLFNILSLAFVGGLPLAYQQTSAFARQPRDELERVRVSCAIIFFASIFQFAIWTTALLHQRETLQPAVQFGGQEHAFMFAKLALYPCASLLAFAATCLLSRFSTAIFHLMQIAVPFAFLLLRLLVRLALAGLQVLWDLWPERPQQDQGEPETQSQLLPASC
uniprot
proteins
function
FUNCTION: Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (By similarity). Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis (By similarity). Regulation of lumenal pH stability is required for autophagosome-lysosome fusion (By similarity). Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes (By similarity). Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (By similarity). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (By similarity). The lysoK(GF) complex is required to protect neurons against stress-induced damage (Probable) (PubMed:32799888). {ECO:0000250|UniProtKB:Q9BSA9, ECO:0000305|PubMed:32799888}.
uniprot
proteins
mass_dalton
55706
uniprot
proteins
protein_family
TMEM175 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23436907
uniprot
proteins
pubmed
32799888
uniprot
proteins
sequence_length
499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q9BSA9}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:23436907}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..53; /note="Helical; Name=TM1-1"; /evidence="ECO:0000250|UniProtKB:Q9BSA9"; TRANSMEM 75..97; /note="Helical; Name=TM2-1"; /evidence="ECO:0000250|UniProtKB:Q9BSA9"; TRANSMEM 104..125; /note="Helical; Name=TM3-1"; /evidence="ECO:0000250|UniProtKB:Q9BSA9"; TRANSMEM 136..157; /note="Helical; Name=TM4-1"; /evidence="ECO:0000250|UniProtKB:Q9BSA9"; TRANSMEM 182..202; /note="Helical; Name=TM5-1"; /evidence="ECO:0000255"; TRANSMEM 208..227; /note="Helical; Name=TM6-1"; /evidence="ECO:0000255"; TRANSMEM 255..279; /note="Helical; Name=TM1-2"; /evidence="ECO:0000250|UniProtKB:Q9BSA9"; TRANSMEM 307..329; /note="Helical; Name=TM2-2"; /evidence="ECO:0000250|UniProtKB:Q9BSA9"; TRANSMEM 336..357; /note="Helical; Name=TM3-2"; /evidence="ECO:0000250|UniProtKB:Q9BSA9"; TRANSMEM 373..393; /note="Helical; Name=TM4-2"; /evidence="ECO:0000250|UniProtKB:Q9BSA9"; TRANSMEM 414..437; /note="Helical; Name=TM5-2"; /evidence="ECO:0000250|UniProtKB:Q9BSA9"; TRANSMEM 440..466; /note="Helical; Name=TM6-2"; /evidence="ECO:0000250|UniProtKB:Q9BSA9
uniprot
proteins