TM9SF4
entrez
9777
canonical
uniprot
Q92544
canonical
ensembl
ENSG00000101337
resolver
ensp
ENSP00000217315
resolver
ensp
ENSP00000381104
resolver
ensp
ENSP00000530272
resolver
ensp
ENSP00000530275
resolver
enst
ENST00000217315
resolver
enst
ENST00000398022
resolver
genesymbol
TM9SF4
resolver
genesymbol_syn
KIAA0255
resolver
genesymbol_syn
TUCAP1
resolver
hgnc
HGNC:30797
resolver
uniprot
A0A024QYR3
resolver
uniprot
A0A0C4DFM1
resolver
uniprot
B0QYT7
resolver
uniprot
B4DH88
resolver
uniprot
Q9NUA3
resolver
uniprot_entry
A0A024QYR3_HUMAN
resolver
uniprot_entry
A0A0C4DFM1_HUMAN
resolver
uniprot_entry
B4DH88_HUMAN
resolver
uniprot_entry
TM9S4_HUMAN
resolver
uniprot_sec
B0QYT7
resolver
uniprot_sec
Q9NUA3
resolver
amino_acid_sequence
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEFIPSLLYFGYTALMVLSFWLLTGTIGFYAAYMFVRKIYAAVKID
uniprot
proteins
function
FUNCTION: Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578). {ECO:0000269|PubMed:19893578, ECO:0000269|PubMed:25659576, ECO:0000269|PubMed:25999474}.
uniprot
proteins
mass_dalton
74519
uniprot
proteins
protein_family
Nonaspanin (TM9SF) (TC 8.A.68) family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
19893578
uniprot
proteins
pubmed
25659576
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
25961573
uniprot
proteins
pubmed
25999474
uniprot
proteins
pubmed
9039502
uniprot
proteins
sequence_length
642
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000269|PubMed:25999474}. Early endosome {ECO:0000269|PubMed:19893578}.
uniprot
proteins
transmembrane_region
TRANSMEM 282..302; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 347..367; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 417..437; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 450..470; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 502..522; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 536..556; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 571..591; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 599..619; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins