KLHL25
entrez
64410
canonical
uniprot
Q9H0H3
canonical
ensembl
ENSG00000183655
resolver
ensp
ENSP00000336800
resolver
ensp
ENSP00000523310
resolver
ensp
ENSP00000523311
resolver
ensp
ENSP00000600136
resolver
ensp
ENSP00000600137
resolver
ensp
ENSP00000626197
resolver
ensp
ENSP00000626198
resolver
ensp
ENSP00000626199
resolver
enst
ENST00000337975
resolver
enst
ENST00000853251
resolver
enst
ENST00000853252
resolver
enst
ENST00000930077
resolver
enst
ENST00000930078
resolver
enst
ENST00000956138
resolver
enst
ENST00000956139
resolver
enst
ENST00000956140
resolver
genesymbol
KLHL25
resolver
genesymbol_syn
ENC2
resolver
hgnc
HGNC:25732
resolver
uniprot
B2RDH2
resolver
uniprot
B3KRT7
resolver
uniprot_entry
KLH25_HUMAN
resolver
uniprot_sec
B2RDH2
resolver
uniprot_sec
B3KRT7
resolver
amino_acid_sequence
MSVSVHETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVSTWKHLPA
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis (PubMed:22578813, PubMed:27664236, PubMed:34491895). The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low (PubMed:22578813). The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E (PubMed:22578813). The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis (PubMed:27664236, PubMed:34491895). BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells (PubMed:34491895). {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:27664236, ECO:0000269|PubMed:34491895}.
uniprot
proteins
mass_dalton
65923
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:27664236, ECO:0000269|PubMed:34491895}.
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
22578813
uniprot
proteins
pubmed
27664236
uniprot
proteins
pubmed
34491895
uniprot
proteins
sequence_length
589
uniprot
proteins