Rragc
entrez
54170
canonical
uniprot
Q99K70
canonical
ensembl
ENSMUSG00000028646
resolver
ensp
ENSMUSP00000030399
resolver
genesymbol
Rragc
resolver
uniprot
A2A7K7
resolver
uniprot
Q3TL69
resolver
uniprot
Q6IQZ6
resolver
uniprot
Q8CFT7
resolver
uniprot
Q9Z124
resolver
uniprot_entry
RRAGC_MOUSE
resolver
uniprot_sec
A2A7K7
resolver
uniprot_sec
Q3TL69
resolver
uniprot_sec
Q6IQZ6
resolver
uniprot_sec
Q8CFT7
resolver
uniprot_sec
Q9Z124
resolver
activity_regulation
ACTIVITY REGULATION: The activation of RagC/RRAGC is mediated by a GTPase activating protein (GAP) (By similarity). In high-amino acid conditions, activated by GTPase activating protein FLCN that stimulates RRAGC GTPase activity to turn it into its active GDP-bound form (By similarity). In response to amino acid depletion, the GATOR1 complex inactivates RagC/RRAGC by securing the GTP-bound inactive form (By similarity). {ECO:0000250|UniProtKB:Q9HB90}.
uniprot
proteins
amino_acid_sequence
MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAGGGGGAGAGGGCGPGGADSSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCSHQTSAPSLKALAHNGTPRNAI
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the MTOR signaling cascade by amino acids. Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3. {ECO:0000250|UniProtKB:Q9HB90}.
uniprot
proteins
mass_dalton
44121
uniprot
proteins
protein_family
GTR/RAG GTP-binding protein family
uniprot
proteins
pubmed
10660099
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25259925
uniprot
proteins
pubmed
29158492
uniprot
proteins
pubmed
29644770
uniprot
proteins
pubmed
30595499
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9HB90}. Nucleus {ECO:0000250|UniProtKB:Q9HB90}. Lysosome membrane {ECO:0000250|UniProtKB:Q9HB90}. Note=Predominantly cytoplasmic. Recruited to the lysosome surface by the Ragulator complex. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA. {ECO:0000250|UniProtKB:Q9HB90}.
uniprot
proteins