Mas1
entrez
17171
canonical
uniprot
P30554
canonical
ensembl
ENSMUSG00000068037
resolver
ensp
ENSMUSP00000086409
resolver
ensp
ENSMUSP00000123902
resolver
ensp
ENSMUSP00000125108
resolver
ensp
ENSMUSP00000131341
resolver
ensp
ENSMUSP00000132300
resolver
ensp
ENSMUSP00000156871
resolver
ensp
ENSMUSP00000233762
resolver
ensp
ENSMUSP00000233771
resolver
enst
ENSMUST00000089015
resolver
enst
ENSMUST00000161747
resolver
enst
ENSMUST00000162333
resolver
enst
ENSMUST00000165020
resolver
enst
ENSMUST00000167152
resolver
enst
ENSMUST00000233607
resolver
genesymbol
Mas1
resolver
genesymbol_syn
Mas
resolver
genesymbol_syn
Mas-1
resolver
uniprot
O35944
resolver
uniprot
Q0VB49
resolver
uniprot
Q8BHI8
resolver
uniprot_entry
MAS_MOUSE
resolver
uniprot_entry
Q0VB49_MOUSE
resolver
uniprot_sec
O35944
resolver
uniprot_sec
Q8BHI8
resolver
amino_acid_sequence
MDQSNMTSLAEEKAMNTSSRNASLGSSHPPIPIVHWVIMSISPLGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHHYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAFVCALLWALSCLVTTMEYVMCIDSGEESHSRSDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYWSAFGNLHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRRQEGNGNTVSIETVV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that plays key roles in the renin-angiotensin system (RAS) specifically in the protective, counter-regulatory arm of the RAS. Receptor mainly stimulated by angiotensin 1-7, which is a bioactive metabolite of the angiotensin produced by ACE2 (PubMed:12829792). Activation promotes nitric oxide via PI3K/Akt-eNOS pathway. Modulates also the MAPK, ERK1/2, and NF-kappa-B signaling. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. Acts as functional receptor for CXCL17 and induces chemotactic movement. {ECO:0000250|UniProtKB:P04201, ECO:0000269|PubMed:12829792}.
uniprot
proteins
mass_dalton
37055
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12829792
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
35979816
uniprot
proteins
pubmed
8001672
uniprot
proteins
pubmed
9268631
uniprot
proteins
pubmed
9565612
uniprot
proteins
sequence_length
324
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P04201}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..60; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 65..86; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 104..127; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 149..171; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 185..205; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 263..283; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins