PAEP
entrez
5047
canonical
uniprot
P09466
canonical
ensembl
ENSG00000122133
resolver
ensp
ENSP00000277508
resolver
ensp
ENSP00000360831
resolver
ensp
ENSP00000417898
resolver
ensp
ENSP00000484659
resolver
ensp
ENSP00000534416
resolver
ensp
ENSP00000534417
resolver
ensp
ENSP00000771576
resolver
ensp
ENSP00000771577
resolver
enst
ENST00000611414
resolver
genesymbol
PAEP
resolver
hgnc
HGNC:8573
resolver
uniprot
A0A087X233
resolver
uniprot
A6XNE0
resolver
uniprot
B2R4F9
resolver
uniprot
B4E3C0
resolver
uniprot
Q5T6T1
resolver
uniprot
Q9UG92
resolver
uniprot_entry
A0A087X233_HUMAN
resolver
uniprot_entry
A6XNE0_HUMAN
resolver
uniprot_entry
B2R4F9_HUMAN
resolver
uniprot_entry
B4E3C0_HUMAN
resolver
uniprot_entry
PAEP_HUMAN
resolver
uniprot_sec
Q5T6T1
resolver
uniprot_sec
Q9UG92
resolver
amino_acid_sequence
MLCLLLTLGVALVCGVPAMDIPQTKQDLELPKLAGTWHSMAMATNNISLMATLKAPLRVHITSLLPTPEDNLEIVLHRWENNSCVEKKVLGEKTENPKKFKINYTVANEATLLDTDYDNFLFLCLQDTTTPIQSMMCQYLARVLVEDDEIMQGFIRAFRPLPRHLWYLLDLKQMEEPCRF
uniprot
proteins
function
FUNCTION: Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:7531163, PubMed:9918684). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260). Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671). Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155). {ECO:0000269|PubMed:12672671, ECO:0000269|PubMed:15883155, ECO:0000269|PubMed:17192260, ECO:0000269|PubMed:7531163, ECO:0000269|PubMed:9918684}.
uniprot
proteins
mass_dalton
20624
uniprot
proteins
post_translational_modification
PTM: Four distinct glycoforms A, C, F and S arise from different N-linked oligosaccharide chains at amino acid residues Asn-46 and Asn-81. Glycodelin-A and -F are taken up by the cumulus cells in which partial deglycosylation takes place to produce glycodelin-C. {ECO:0000269|PubMed:12672671, ECO:0000269|PubMed:17192260, ECO:0000269|PubMed:7592613, ECO:0000269|PubMed:8943270}.
uniprot
proteins
protein_family
Calycin superfamily
uniprot
proteins
protein_family
Lipocalin family
uniprot
proteins
pubmed
11278680
uniprot
proteins
pubmed
12672671
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15883155
uniprot
proteins
pubmed
17192260
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
2006183
uniprot
proteins
pubmed
2206398
uniprot
proteins
pubmed
25422905
uniprot
proteins
pubmed
3194393
uniprot
proteins
pubmed
3569148
uniprot
proteins
pubmed
3667877
uniprot
proteins
pubmed
7531163
uniprot
proteins
pubmed
7592613
uniprot
proteins
pubmed
8943270
uniprot
proteins
pubmed
9239694
uniprot
proteins
pubmed
9918684
uniprot
proteins
sequence_length
180
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12672671, ECO:0000269|PubMed:17192260, ECO:0000269|PubMed:3667877}.
uniprot
proteins