Kcnj3
entrez
16519
canonical
uniprot
P63250
canonical
ensembl
ENSMUSG00000026824
resolver
ensp
ENSMUSP00000063329
resolver
ensp
ENSMUSP00000108251
resolver
ensp
ENSMUSP00000108252
resolver
enst
ENSMUST00000067101
resolver
enst
ENSMUST00000112632
resolver
enst
ENSMUST00000112633
resolver
genesymbol
Kcnj3
resolver
genesymbol_syn
Girk1
resolver
uniprot
B1AYE4
resolver
uniprot
P35562
resolver
uniprot
Q3ZAT1
resolver
uniprot_entry
B1AYE4_MOUSE
resolver
uniprot_entry
KCNJ3_MOUSE
resolver
uniprot_entry
Q3ZAT1_MOUSE
resolver
uniprot_sec
P35562
resolver
activity_regulation
ACTIVITY REGULATION: Heteromultimer composed of KCNJ3/GIRK1 and KCNJ5/GIRK4 is activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2). {ECO:0000250|UniProtKB:P63251}.
uniprot
proteins
amino_acid_sequence
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQGPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEVVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDISTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGPTRMEGNLPAKLRKMNSDRFT
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins (PubMed:32617840). This receptor plays a crucial role in regulating the heartbeat (By similarity). Forms a functional channel in association with KCNJ5/GIRK4 or KCNJ6/GIRK2 or KCNJ9/GIRK3 (PubMed:10341034). {ECO:0000250|UniProtKB:P48549, ECO:0000250|UniProtKB:P63251, ECO:0000269|PubMed:10341034, ECO:0000269|PubMed:32617840}.
uniprot
proteins
mass_dalton
56573
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ3 subfamily
uniprot
proteins
pubmed
10341034
uniprot
proteins
pubmed
12507423
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32617840
uniprot
proteins
pubmed
7702616
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 81..105; /note="Helical; Name=M1"; /evidence="ECO:0000250"; TRANSMEM 158..179; /note="Helical; Name=M2"; /evidence="ECO:0000250
uniprot
proteins