Tgs1
entrez
312947
canonical
uniprot
P85107
canonical
ensembl
ENSRNOG00000008156
resolver
ensp
ENSRNOP00000010783
resolver
enst
ENSRNOT00000010783
resolver
genesymbol
Tgs1
resolver
genesymbol_syn
Ncoa6ip
resolver
genesymbol_syn
Pimt
resolver
uniprot_entry
TGS1_RAT
resolver
amino_acid_sequence
MCCEKWSHVAEMLLFIEDREEEYKILCLCSRAFVEDRKLYNLGLKGYYVKSSGNNAGDRVTEEEEDDHSSGTTESHSADEGDLDPEAKLMRSMGLPVRFGRMSTHGSFEVSMNARNKAKVRQKRRKHRKQYLDEIVREDWRNDCEEDDLVVSDDPSSVEHCENNSACEIQSKTDAEAENLPVENTLAPKLEVTENWEKYWNEYGEGLLWQSWQEKYPDQTLSSEPWNLPDTKEEWEQHYSQLYWYYLEQFQYWEAQGWTFVASQNCDKDVCTSHTQVDQNAESSLKADGTTLSSSPNTAEDESLGSNDNDHNEIIAGINKITLSAEEVEQSQLDSSEHCDKPLSEVTGKECPASGGSDSCHGTPKESDISENRSSDQPAQELQESSGTNTSKHRPHHNGTDGNESEDDPPDHKPSKMKRSHELDIDENPDSEVDDNGFHLGFKHGSGQKYGGIPNFSRRQVRYLEKNVKYKSKYLDMRKRMTVKNKHIVFSEESGKPFIRKSKVRSKVEKFLKWVNEPVDEEISQEPLSHNKMQDTCTSSDSEEQDMSMEKTDGLMETRDPEPENCQTISSASELEAEKSEGGSLVAAVPENCSTEGVANSPRAEAEVEIKKKKKKKKKNKNKKINGLPPEIASVPELAKYWAQRYRLFSRFDDGIKLDKEGWFSVTPEKIAEHIAGRVSQSFNCDIIVDAFCGVGGNTIQFALTGKRVIAIDIDPVKIDLARNNAEVYGVADKIEFICGDFLLLAPCLKADVVFLSPPWGGPDYATAETFDIRTMMSPDGFEIFRLSQKITNNIVYFLPRNADVDQVASLAGPGGQVEIEQNFLNNKLKTITAYFGDLIRRPALRSAEA
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation (By similarity). {ECO:0000250|UniProtKB:Q96RS0}.
uniprot
proteins
mass_dalton
96045
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
protein_family
Trimethylguanosine synthase family
uniprot
proteins
pubmed
12943661
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
850
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96RS0}. Nucleus, Cajal body {ECO:0000250|UniProtKB:Q96RS0}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q96RS0}.
uniprot
proteins