Sh3gl2
entrez
116743
canonical
uniprot
O35179
canonical
ensembl
ENSRNOG00000006761
resolver
ensp
ENSRNOP00000087931
resolver
ensp
ENSRNOP00000098240
resolver
enst
ENSRNOT00000110787
resolver
enst
ENSRNOT00000120604
resolver
genesymbol
Sh3gl2
resolver
genesymbol_syn
Sh3d2a
resolver
genesymbol_syn
Sh3p4
resolver
uniprot
A0A8I6GFM2
resolver
uniprot_entry
A0A8I6GFM2_RAT
resolver
uniprot_entry
SH3G2_RAT
resolver
amino_acid_sequence
MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFATGDGTQPNGGLSHTGTPKPAGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFPINYVEILVALPH
uniprot
proteins
function
FUNCTION: Implicated in endocytosis (PubMed:11604418, PubMed:16763559). Involved ultrafast endocytosis, by mediating, in a first step, neck formation and in a second step, aids in the removal of clathrin coats from the regenerated vesicles (By similarity). May recruit other proteins to membranes with high curvature (By similarity) (PubMed:11604418, PubMed:16763559). Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:Q62420, ECO:0000269|PubMed:11604418, ECO:0000269|PubMed:16763559}.
uniprot
proteins
mass_dalton
39899
uniprot
proteins
mutagenesis
MUTAGEN 263; /note="L->P: Confers inhibition of transferrin uptake comparable to Sh3gl3 upon overexpression."; /evidence="ECO:0000269|PubMed:15066995
uniprot
proteins
protein_family
Endophilin family
uniprot
proteins
pubmed
11384986
uniprot
proteins
pubmed
11604418
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15066995
uniprot
proteins
pubmed
16319893
uniprot
proteins
pubmed
16763557
uniprot
proteins
pubmed
16763559
uniprot
proteins
pubmed
8889548
uniprot
proteins
pubmed
9238017
uniprot
proteins
pubmed
9341169
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9238017, ECO:0000269|PubMed:9341169}. Membrane {ECO:0000269|PubMed:9238017}; Peripheral membrane protein {ECO:0000269|PubMed:9238017}. Early endosome {ECO:0000250|UniProtKB:Q62420}. Presynapse {ECO:0000269|PubMed:9341169}.
uniprot
proteins