DHRS11
entrez
79154
canonical
uniprot
Q6UWP2
canonical
ensembl
ENSG00000275397
resolver
ensembl
ENSG00000278535
resolver
ensp
ENSP00000482704
resolver
ensp
ENSP00000522332
resolver
ensp
ENSP00000621402
resolver
genesymbol
DHRS11
resolver
genesymbol_syn
SDR24C1
resolver
hgnc
HGNC:28639
resolver
uniprot
A0A0U5BLD0
resolver
uniprot
B2RDZ3
resolver
uniprot
Q9BUC7
resolver
uniprot
Q9H674
resolver
uniprot_entry
DHR11_HUMAN
resolver
uniprot_sec
A0A0U5BLD0
resolver
uniprot_sec
B2RDZ3
resolver
uniprot_sec
Q9BUC7
resolver
uniprot_sec
Q9H674
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by flavonoids including apigenin, luteolin, genistein, kaempferol and quercetin and also by carbenoxolone, zearalenone, glycyrrhetinic, curcumin and flufenamic acid. {ECO:0000269|PubMed:26920053}.
uniprot
proteins
amino_acid_sequence
MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVLSTPAHIQIGDIQMRPTEQVT
uniprot
proteins
ec_number
1.1.1.270
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3beta-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids (PubMed:26920053). May contribute to the metabolism of adrenal-derived androgen precursors. Reduces 11-keto-4-androstene-3,17-dione (11KA4) and 11-keto-5alpha-androstane-3,17-dione (11K-Adione) into potent androgens 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone (11KDHT), respectively (PubMed:31926269). May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones (PubMed:26920053). {ECO:0000269|PubMed:26920053, ECO:0000269|PubMed:31926269}.
uniprot
proteins
mass_dalton
28308
uniprot
proteins
mutagenesis
MUTAGEN 163; /note="T->G: Decreases the reductase activity toward androstane substrates including androst-4-ene-3,11,17-trione (11KA4), 5alpha-androstan-3,11,17-trione (11K-Adione), epiandrosterone and androstenedione (A4)."; /evidence="ECO:0000269|PubMed:31926269"; MUTAGEN 200; /note="V->L: Switches the positional specificity of the reductase activity from 17beta to 3beta. Acquires 3beta-hydroxysteroid dehydrogenase activity toward 5alpha-androstanes such as dihydrotestosterone (DHT), 11-keto DHT (11KDHT), 5alpha-androstan-3,17-dione (Adione) and 11keto-Adione. Increases the Vmax of the reductase activity for Adione and 11keto-Adione. Decreases the catalytic efficiency toward epiandrosterone. No significant effect on the reductase activity toward 4-androstenes androstenedione (A4) and androst-4-ene-3,11,17-trione (11KA4)."; /evidence="ECO:0000269|PubMed:31926269
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; estrogen biosynthesis. {ECO:0000305|PubMed:26920053}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19027726
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
26920053
uniprot
proteins
pubmed
31926269
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins