Trim30a
entrez
20128
canonical
uniprot
P15533
canonical
ensembl
ENSMUSG00000030921
resolver
ensp
ENSMUSP00000076189
resolver
ensp
ENSMUSP00000275751
resolver
ensp
ENSMUSP00000275753
resolver
ensp
ENSMUSP00000275754
resolver
genesymbol
Trim30a
resolver
genesymbol_syn
Rpt-1
resolver
genesymbol_syn
Rpt1
resolver
genesymbol_syn
Trim30
resolver
uniprot
Q3UV85
resolver
uniprot
Q3UZ29
resolver
uniprot
Q99K55
resolver
uniprot
Q99PQ7
resolver
uniprot
Q99PQ8
resolver
uniprot
Q99PQ9
resolver
uniprot_entry
TR30A_MOUSE
resolver
uniprot_sec
Q3UV85
resolver
uniprot_sec
Q3UZ29
resolver
uniprot_sec
Q99K55
resolver
uniprot_sec
Q99PQ7
resolver
uniprot_sec
Q99PQ8
resolver
uniprot_sec
Q99PQ9
resolver
amino_acid_sequence
MASSVLEMIKEEVTCPICLELLKEPVSADCNHSFCRACITLNYESNRNTDGKGNCPVCRVPYPFGNLRPNLHVANIVERLKGFKSIPEEEQKVNICAQHGEKLRLFCRKDMMVICWLCERSQEHRGHQTALIEEVDQEYKEKLQGALWKLMKKAKICDEWQDDLQLQRVDWENQIQINVENVQRQFKGLRDLLDSKENEELQKLKKEKKEVMEKLEESENELEDQTELVRDLISDVEHHLELSTLEMLQGANCVLRRSQSLSLQQPQTVPQKRKRTFQAPDLKGMLQVYQGLMDIQQYWVHMTLHARNNAVIAINKEKRQIQYRSYNTVPVSEIYHLGVLGYPALSSGKHYWEVDISRSDAWLLGLNDGKCAQPQLHSKEEMGIKKNLHSQIKQNVLFQPKCGYWVIGMKNPSVYKAFDECSITHNSSILVISLPDRPSRVGVFLDRKAGTLSFYDVSNCGALIYRFYDPAFPVEVYPYFNPMKCSEPMTICGPPS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of innate immune responses, and which is required to prevent excessive inflammation (PubMed:18345001, PubMed:19147168, PubMed:21048113, PubMed:26114947). Negatively regulates Toll-like receptor (TLR)-mediated activation of NF-kappa-B by promoting ubiquitination and degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination (PubMed:18345001). Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex (PubMed:21048113). This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18 (PubMed:21048113). Acts as a negative regulator of cGAS-STING signaling by mediating ubiquitination and degradation of STING1 (PubMed:26114947). {ECO:0000269|PubMed:18345001, ECO:0000269|PubMed:19147168, ECO:0000269|PubMed:21048113, ECO:0000269|PubMed:26114947}.
uniprot
proteins
mass_dalton
57330
uniprot
proteins
mutagenesis
MUTAGEN 35; /note="C->A: Abolished E3 ubiquitin-protein ligase activity."; /evidence="ECO:0000269|PubMed:26114947"; MUTAGEN 35; /note="C->S: Reduced interaction with MAP3K7 and enhanced interaction with TAB2 and TAB3. Does not decrease TAB2 or TAB3 expression. No effect on inhibition of ROS or negative regulation of NLRP3 inflammasome activation."; /evidence="ECO:0000269|PubMed:18345001, ECO:0000269|PubMed:21048113
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:26114947}.
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18345001
uniprot
proteins
pubmed
19147168
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21048113
uniprot
proteins
pubmed
26114947
uniprot
proteins
pubmed
2965815
uniprot
proteins
sequence_length
496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
uniprot
proteins