Impdh2
entrez
301005
canonical
uniprot
E9PU28
canonical
ensembl
ENSRNOG00000031965
resolver
ensp
ENSRNOP00000040635
resolver
ensp
ENSRNOP00000108718
resolver
enst
ENSRNOT00000166384
resolver
genesymbol
Impdh2
resolver
genesymbol_syn
IMPDH
resolver
uniprot
A0ABK0LWG5
resolver
uniprot
Q6P9U9
resolver
uniprot_entry
A0ABK0LWG5_RAT
resolver
uniprot_entry
IMDH2_RAT
resolver
uniprot_entry
Q6P9U9_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. {ECO:0000255|HAMAP-Rule:MF_03156}.
uniprot
proteins
amino_acid_sequence
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGVTLKEANEILQRSKKGKLPIVNESDELVAIIARTDLKKNRDYPLASKDTKKQLLCGAAIGTHEDDKYRLDLLALAGVDVVVLDSSQGNSIFQINMIKYIKEKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHGLHSYEKRLF
uniprot
proteins
ec_number
1.1.1.205
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000250|UniProtKB:P12268}.
uniprot
proteins
mass_dalton
55815
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1. {ECO:0000250|UniProtKB:P12268}.
uniprot
proteins
post_translational_modification
PTM: Acetylated by CLOCK in a circadian manner. {ECO:0000250|UniProtKB:P12268}.; PTM: Ubiquitinated leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:P12268}.
uniprot
proteins
protein_family
IMPDH/GMPR family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P12268}. Nucleus {ECO:0000250|UniProtKB:P12268}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P12268}. Note=Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine-nucleotide depletion. {ECO:0000250|UniProtKB:P12268}.
uniprot
proteins