OTOP3
entrez
347741
canonical
uniprot
Q7RTS5
canonical
ensembl
ENSG00000182938
resolver
ensp
ENSP00000328090
resolver
ensp
ENSP00000626815
resolver
genesymbol
OTOP3
resolver
hgnc
HGNC:19658
resolver
uniprot
A0A2U3TZI1
resolver
uniprot_entry
OTOP3_HUMAN
resolver
uniprot_sec
A0A2U3TZI1
resolver
activity_regulation
ACTIVITY REGULATION: Activated by extracellular acidification (By similarity). Activated by Zn(2+) under non-acidic conditions (By similarity). {ECO:0000250|UniProtKB:Q80UF9}.
uniprot
proteins
amino_acid_sequence
MGRGARAAAAQSRWGRASRASVSPGRTIRSAPAVGEAQETEAAPEKENRVDVGAEERAAATRPRQKSWLVRHFSLLLRRDRQAQKAGQLFSGLLALNVVFLGGAFICSMIFNKVAVTLGDVWILLATLKVLSLLWLLYYVASTTRRPHAVLYQDPHAGPLWVRGSLVLFGSCTFCLNIFRVGYDVSHIRCKSQLDLVFSVIEMVFIGVQTWVLWKHCKDCVRVQTNFTRCGLMLTLATNLLLWVLAVTNDSMHREIEAELGILMEKSTGNETNTCLCLNATACEAFRRGFLMLYPFSTEYCLICCAVLFVMWKNVGRHVAPHMGAHPATAPFHLHGAIFGPLLGLLVLLAGVCVFVLFQIEASGPAIACQYFTLYYAFYVAVLPTMSLACLAGTAIHGLEERELDTVKNPTRSLDVVLLMGAALGQMGIAYFSIVAIVAKRPHELLNRLILAYSLLLILQHIAQNLFIIEGLHRRPLWETVPEGLAGKQEAEPPRRGSLLELGQGLQRASLAYIHSYSHLNWKRRALKEISLFLILCNITLWMMPAFGIHPEFENGLEKDFYGYQIWFAIVNFGLPLGVFYRMHSVGGLVEVYLGA
uniprot
proteins
function
FUNCTION: Proton-selective channel gated by extracellular protons. {ECO:0000250|UniProtKB:Q80UF9}.
uniprot
proteins
mass_dalton
66296
uniprot
proteins
protein_family
Otopetrin family
uniprot
proteins
pubmed
12651873
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18669648
uniprot
proteins
sequence_length
596
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q80UF9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A9JTM7}.
uniprot
proteins
transmembrane_region
TRANSMEM 89..109; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 120..143; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 160..181; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 194..217; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 226..248; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 296..312; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 339..358; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 373..395; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 414..435; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 447..469; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 530..547; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 567..589; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:A9JTM7
uniprot
proteins