TOP1MT
entrez
116447
canonical
uniprot
Q969P6
canonical
ensembl
ENSG00000184428
resolver
ensp
ENSP00000328835
resolver
ensp
ENSP00000428369
resolver
ensp
ENSP00000429169
resolver
genesymbol
TOP1MT
resolver
hgnc
HGNC:29787
resolver
uniprot
B4DYD2
resolver
uniprot
B7ZAR5
resolver
uniprot
E5KMK7
resolver
uniprot
E7ES89
resolver
uniprot
Q86ST4
resolver
uniprot
Q86V82
resolver
uniprot_entry
B4DYD2_HUMAN
resolver
uniprot_entry
E5KMK7_HUMAN
resolver
uniprot_entry
TOP1M_HUMAN
resolver
uniprot_sec
B7ZAR5
resolver
uniprot_sec
E7ES89
resolver
uniprot_sec
Q86ST4
resolver
uniprot_sec
Q86V82
resolver
amino_acid_sequence
MRVVRLLRLRAALTLLGEVPRRPASRGVPGSRRTQKGSGARWEKEKHEDGVKWRQLEHKGPYFAPPYEPLPDGVRFFYEGRPVRLSVAAEEVATFYGRMLDHEYTTKEVFRKNFFNDWRKEMAVEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSREEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIPEPPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQATDKEENKQVALGTSKLNYLDPRISIAWCKRFRVPVEKIYSKTQRERFAWALAMAGEDFEF
uniprot
proteins
ec_number
5.6.2.1
uniprot
proteins
function
FUNCTION: Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). {ECO:0000250, ECO:0000269|PubMed:11526219}.
uniprot
proteins
mass_dalton
69872
uniprot
proteins
protein_family
Type IB topoisomerase family
uniprot
proteins
pubmed
11526219
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
sequence_length
601
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11526219}.
uniprot
proteins