Rngtt
entrez
24018
canonical
uniprot
O55236
canonical
ensembl
ENSMUSG00000028274
resolver
ensp
ENSMUSP00000029942
resolver
ensp
ENSMUSP00000103788
resolver
ensp
ENSMUSP00000300991
resolver
ensp
ENSMUSP00000300992
resolver
ensp
ENSMUSP00000300995
resolver
ensp
ENSMUSP00000326885
resolver
enst
ENSMUST00000029942
resolver
enst
ENSMUST00000108153
resolver
genesymbol
Rngtt
resolver
genesymbol_syn
Cap1a
resolver
uniprot
F8WHZ5
resolver
uniprot
Q3UA94
resolver
uniprot
Q9DCC1
resolver
uniprot_entry
F8WHZ5_MOUSE
resolver
uniprot_entry
MCE1_MOUSE
resolver
uniprot_entry
Q3UA94_MOUSE
resolver
uniprot_entry
Q9DCC1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: RNA triphosphatase activity is inhibited by vanadate, iodoacetate and magnesium.
uniprot
proteins
amino_acid_sequence
MAYNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYLKSLKVKMSLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERSPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGDYLKELFRRYGDIEEAPPPPVLPDWCFEDEDEEDEDEDGKKDSEPGSSASFSKRRKERLKLGAIFLEGITVKGVTQVTTQPKLGEVQQKCHQFCGWEGSGFPGAQPVSMDKQNIRLLEQKPYKVSWKADGTRYMMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLRMHLSNTLLDGEMIIDKVNGQAVPRYLIYDIIKFNAQPVGDCDFNIRLQCIEREIISPRHEKMKTGLIDKTQEPFSVRPKQFFDINISRKLLEGNFAKEVSHEMDGLIFQPIGKYKPGRCDDILKWKPPSLNSVDFRLKITRMGGEGLLPQNVGLLYVGGYERPFAQIKVTKELKQYDNKIIECKFENNSWVFMRQRIDKSFPNAYNTAMAVCNSISNPVTKEMLFEFIDRCAAAAQGQKRKYPLDPDTELMPPPPPKRLHRPT
uniprot
proteins
ec_number
2.7.7.50
uniprot
proteins
ec_number
3.6.1.74
uniprot
proteins
function
FUNCTION: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate. {ECO:0000269|PubMed:21683636, ECO:0000269|PubMed:9371772}.
uniprot
proteins
mass_dalton
68684
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="D->A: No effect."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 66; /note="D->A: Decrease of >90% of TPase activity."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 110; /note="C->S: No effect."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 125; /note="H->A: Decrease of 55-60% of TPase activity."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 126; /note="C->S: Loss of TPase activity."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 132; /note="R->A: Loss of TPase activity."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 133; /note="T->A: Decrease of 55-60% of TPase activity."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 138; /note="C->S: No effect."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 168; /note="D->A: No effect."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 290; /note="K->A: No effect."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 294; /note="K->A: Loss of GTase activity."; /evidence="ECO:0000269|PubMed:9371772"; MUTAGEN 315; /note="R->A: Almost complete loss of RNA-binding and loss of GTase activity."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 315; /note="R->K: At least 60% of RNA-binding activity and loss of GTase activity."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 375; /note="C->R: Increases stimulation of GTase activity by POLR2A binding."; /evidence="ECO:0000269|PubMed:21683636"; MUTAGEN 530; /note="R->A: Almost complete loss of RNA-binding and loss of GTase activity."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 530; /note="R->K: Loss of GTase activity."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 533; /note="K->A: Almost complete loss of RNA-binding and loss of GTase activity."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 533; /note="K->R: At least 60% of RNA-binding activity and loss of GTase activity."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 537; /note="N->A: Almost complete loss of RNA-binding and loss of GTase activity."; /evidence="ECO:0000269|PubMed:9770468"; MUTAGEN 537; /note="N->Q: At least 60% of RNA binding activity and loss of GTase activity."; /evidence="ECO:0000269|PubMed:9770468
uniprot
proteins
protein_family
Non-receptor class of the protein-tyrosine phosphatase family; Eukaryotic GTase family
uniprot
proteins
pubmed
11350947
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21683636
uniprot
proteins
pubmed
9371772
uniprot
proteins
pubmed
9407024
uniprot
proteins
pubmed
9770468
uniprot
proteins
sequence_length
597
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins