Lgi1
entrez
56839
canonical
uniprot
Q9JIA1
canonical
ensembl
ENSMUSG00000067242
resolver
ensp
ENSMUSP00000143128
resolver
genesymbol
Lgi1
resolver
uniprot
A0A0G2JFT0
resolver
uniprot_entry
LGI1_MOUSE
resolver
uniprot_sec
A0A0G2JFT0
resolver
amino_acid_sequence
MESESSRRMGNACIPLKRIAYFLCLFSVVLLTEGKKPAKPKCPAVCTCSKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNAFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSPKDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIDTQLYVIVAQLFGGSHIYKRDGFANKFIKIQDIEVLKIRKPNDIETFKIEDNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIARPPLALRTPHLILSSSSQRPVIYQWSKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA
uniprot
proteins
function
FUNCTION: Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity). {ECO:0000250|UniProtKB:O95970}.
uniprot
proteins
mass_dalton
63644
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:O95970}.
uniprot
proteins
pubmed
10920229
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15857855
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
16787412
uniprot
proteins
pubmed
18974846
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19833108
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26269648
uniprot
proteins
sequence_length
557
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15857855}. Synapse {ECO:0000250|UniProtKB:Q8K4Y5}. Cytoplasm {ECO:0000269|PubMed:26269648}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16787412}. Golgi apparatus {ECO:0000250|UniProtKB:O95970}. Secreted {ECO:0000250|UniProtKB:O95970}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16787412}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O95970}.
uniprot
proteins