Igfbp3
entrez
16009
canonical
uniprot
P47878
canonical
ensembl
ENSMUSG00000020427
resolver
ensp
ENSMUSP00000020702
resolver
ensp
ENSMUSP00000131670
resolver
enst
ENSMUST00000020702
resolver
enst
ENSMUST00000135887
resolver
genesymbol
Igfbp3
resolver
genesymbol_syn
Igfbp-3
resolver
uniprot
Q3UR87
resolver
uniprot
Q6PE62
resolver
uniprot_entry
IBP3_MOUSE
resolver
uniprot_entry
Q3UR87_MOUSE
resolver
uniprot_sec
Q6PE62
resolver
amino_acid_sequence
MHPARPALWAAALTALTLLRGPPVARAGAGAVGAGPVVRCEPCDARALSQCAPPPTAPACTELVREPGCGCCLTCALREGDACGVYTERCGTGLRCQPRPAEQYPLRALLNGRGFCANASAAGSLSTYLPSQPAPGNISESEEEHNAGSVESQVVPSTHRVTDSKFHPLHAKMDVIKKGHARDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYDTKGKDDVHCLSVQSQ
uniprot
proteins
function
FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Promotes testicular germ cell apoptosis. {ECO:0000250|UniProtKB:P17936}.
uniprot
proteins
mass_dalton
31687
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FAM20C in the extracellular medium. {ECO:0000250|UniProtKB:P17936}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19952275
uniprot
proteins
pubmed
7529732
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins