Otud3
entrez
73162
canonical
uniprot
B1AZ99
canonical
ensembl
ENSMUSG00000041161
resolver
ensp
ENSMUSP00000095441
resolver
ensp
ENSMUSP00000283579
resolver
enst
ENSMUST00000097830
resolver
genesymbol
Otud3
resolver
uniprot_entry
OTUD3_MOUSE
resolver
amino_acid_sequence
MSRKQAAKSRPGSGGRRAEAERKRDERAARRALAKERRNRPDPGGSGCEEEFVSFANQLQALGLKLREVPGDGNCLFRALGDQLEGHSRNHLKHRQETVDYMIRQREDFEPFVEDDIPFEKHVASLSKPGTFAGNDAIVAFARNHQLNVVIHQLNAPLWQIRGTDKGSTRELHIAYRYGEHYDSVRRINDNSEAPAHLLTDFQMLHQDGANKKEKMKTKGVDVKDGLRDDVEDAVHKVGSATGCTDFNLIVQNLEAENYNIKSAITALLQVNQGTGNDAEENHEPGDRVKQRGPSREEAGSGRRLSGNQGRNEGRMETSEARASPAEESKAHKSQLPKVTNKQRREQQRLEKKKRQEERHRLKALENRNGSRDTGRSEADMNTQVTLVKTFAALNI
uniprot
proteins
ec_number
3.4.19.12
uniprot
proteins
function
FUNCTION: Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin (PubMed:35675826). Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (PubMed:35675826). Important regulator of energy metabolism (PubMed:35675826). Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation (PubMed:35675826). In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation (PubMed:35675826). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q5T2D3, ECO:0000269|PubMed:35675826}.
uniprot
proteins
mass_dalton
44576
uniprot
proteins
post_translational_modification
PTM: Glucose and fatty acids stimulate CREBBP-dependent acetylation, promoting its nuclear translocation. {ECO:0000269|PubMed:35675826}.
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
35675826
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:35675826}. Nucleus {ECO:0000269|PubMed:35675826}. Note=Glucose or fatty acid promote nuclear translocation upon acetylation. {ECO:0000269|PubMed:35675826}.
uniprot
proteins