Knstrn
entrez
311325
canonical
uniprot
Q6AXN6
canonical
ensembl
ENSRNOG00000009334
resolver
ensp
ENSRNOP00000012454
resolver
ensp
ENSRNOP00000104011
resolver
enst
ENSRNOT00000012454
resolver
enst
ENSRNOT00000131514
resolver
genesymbol
Knstrn
resolver
genesymbol_syn
Skap
resolver
genesymbol_syn
Traf4af1
resolver
uniprot
A0A8L2Q5L7
resolver
uniprot_entry
A0A8L2Q5L7_RAT
resolver
uniprot_entry
SKAP_RAT
resolver
amino_acid_sequence
MATHKAEAQETDFRTTGPPTDLEQCPFPPSSRKFPFESVAADSTEGWAVAAEHHLKRSGEDGGWEQPASGVEPSRPTTMASSKTVCDAQPHSMPSCGLSADTQTRATSKLPVKSKDAEMLRHLHTGGLEPDVTKVTKPRRENGQGKAAETASRRNIRSSYKPLSKQKPEEDLKDKNELLEAVNKQLHQKLTETQGELKDLTQKVELLEKFQDNCLAILESKGLNSGQETQESKQEPSTDPTDSMLLLETLKDELKLFNETAKKQMEELQALKVKLKLKEKERIQFLEQQTLGKDEASDFTIILEEMEQLLEM
uniprot
proteins
function
FUNCTION: Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. {ECO:0000250|UniProtKB:Q9Y448}.
uniprot
proteins
mass_dalton
34885
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
312
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y448}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9Y448}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9Y448}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q9Y448}. Note=Colocalizes with microtubules around centrosomes in prophase and with the mitotic spindle at prometaphase and metaphase. From late prometaphase to anaphase, is highly concentrated on kinetochores. Located at the kinetochore-microtubule interface. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends. {ECO:0000250|UniProtKB:Q9Y448}.
uniprot
proteins