PMAIP1
entrez
5366
canonical
uniprot
Q13794
canonical
ensembl
ENSG00000141682
resolver
ensp
ENSP00000269518
resolver
ensp
ENSP00000326119
resolver
ensp
ENSP00000642922
resolver
genesymbol
PMAIP1
resolver
genesymbol_syn
NOXA
resolver
hgnc
HGNC:9108
resolver
uniprot
A0A0S2Z490
resolver
uniprot
A0A0S2Z4V2
resolver
uniprot
B2R4T7
resolver
uniprot
Q8N589
resolver
uniprot_entry
A0A0S2Z490_HUMAN
resolver
uniprot_entry
A0A0S2Z4V2_HUMAN
resolver
uniprot_entry
APR_HUMAN
resolver
uniprot_sec
B2R4T7
resolver
uniprot_sec
Q8N589
resolver
amino_acid_sequence
MPGKKARKNAQPSPARAPAELEVECATQLRRFGDKLNFRQKLLNLISKLFCSGT
uniprot
proteins
function
FUNCTION: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. {ECO:0000250, ECO:0000269|PubMed:10807576, ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615, ECO:0000269|PubMed:17389404}.
uniprot
proteins
mass_dalton
6030
uniprot
proteins
mutagenesis
MUTAGEN 29; /note="L->A: Reduced interaction with BAX."; /evidence="ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17389404"; MUTAGEN 29; /note="L->E: Loss of interaction with MCL1 and of increased MCL1 degradation; when associated with E-32 and E-32."; /evidence="ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17389404"; MUTAGEN 32; /note="F->E: Loss of interaction with MCL1 and of increased MCL1 degradation; when associated with E-29 and E-36."; /evidence="ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:17389404"; MUTAGEN 32; /note="F->I: Alters specificity of protein interaction and enhances pro-apoptotic activity; when associated with E-35."; /evidence="ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:17389404"; MUTAGEN 35; /note="K->E: Alters specificity of protein interaction and enhances pro-apoptotic activity; when associated with I-32."; /evidence="ECO:0000269|PubMed:15694340"; MUTAGEN 36; /note="L->E: Loss of interaction with MCL1 and of increased MCL1 degradation; when associated with E-29 and E-32."; /evidence="ECO:0000269|PubMed:17389404
uniprot
proteins
protein_family
PMAIP1 family
uniprot
proteins
pubmed
10807576
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15694340
uniprot
proteins
pubmed
15705586
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
17374615
uniprot
proteins
pubmed
17389404
uniprot
proteins
pubmed
23563182
uniprot
proteins
pubmed
2398525
uniprot
proteins
sequence_length
54
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:15705586, ECO:0000269|PubMed:17374615}.
uniprot
proteins