Atp5if1
entrez
11983
canonical
uniprot
O35143
canonical
ensembl
ENSMUSG00000054428
resolver
ensp
ENSMUSP00000064282
resolver
ensp
ENSMUSP00000341297
resolver
ensp
ENSMUSP00000364668
resolver
enst
ENSMUST00000067496
resolver
genesymbol
Atp5if1
resolver
genesymbol_syn
Atpi
resolver
genesymbol_syn
Atpif1
resolver
genesymbol_syn
If1
resolver
uniprot
Q9D879
resolver
uniprot_entry
ATIF1_MOUSE
resolver
uniprot_sec
Q9D879
resolver
amino_acid_sequence
MAGSALAVRARFGVWGMKVLQTRGFVSDSSDSMDTGAGSIREAGGAFGKREKAEEDRYFREKTKEQLAALRKHHEDEIDHHSKEIERLQKQIERHKKKIQQLKNNH
uniprot
proteins
function
FUNCTION: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase (By similarity). Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme (PubMed:23135403). {ECO:0000250|UniProtKB:P01096, ECO:0000269|PubMed:23135403}.
uniprot
proteins
mass_dalton
12159
uniprot
proteins
protein_family
ATPase inhibitor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23135403
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
9497501
uniprot
proteins
sequence_length
106
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
uniprot
proteins