Mreg
entrez
381269
canonical
uniprot
Q6NVG5
canonical
ensembl
ENSMUSG00000039395
resolver
ensp
ENSMUSP00000041878
resolver
enst
ENSMUST00000048860
resolver
genesymbol
Mreg
resolver
genesymbol_syn
Dsu
resolver
genesymbol_syn
Gm974
resolver
genesymbol_syn
Wdt2
resolver
uniprot_entry
MREG_MOUSE
resolver
amino_acid_sequence
MGLRRWLRSACCCCPCRCLEEPARPEKEPLVSGNNPYSSFGATLERDDEKNLWSMPHDVSHTEADDDRILYNLIVIRNQQTKDSEEWQRLNYDIYTLRQIRREVRNRWRRILEDLGFQREADSLLSVTKLSTMSDSKNTRKAREMLLKLAEETSIFPASWELSERYLLVVDRLIALDAAEDFFKIASQMYPKKPGVPCLVDGQRKLHCLPFPSP
uniprot
proteins
function
FUNCTION: Probably functions as a cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery (PubMed:22275436, PubMed:22940130, PubMed:30174147). Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes (PubMed:15550542, PubMed:22753477, PubMed:3410303). Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center (PubMed:22275436, PubMed:22940130). Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell (PubMed:19240024, PubMed:30174147). Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport (PubMed:30174147). Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (PubMed:19240024). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye (PubMed:19240024). May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (Probable). {ECO:0000269|PubMed:15550542, ECO:0000269|PubMed:19240024, ECO:0000269|PubMed:22275436, ECO:0000269|PubMed:22753477, ECO:0000269|PubMed:22940130, ECO:0000269|PubMed:30174147, ECO:0000269|PubMed:3410303, ECO:0000305|PubMed:17260955}.
uniprot
proteins
mass_dalton
25010
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: No effect on location at the melanosome membrane."; /evidence="ECO:0000269|PubMed:22940130"; MUTAGEN 11..14; /note="CCCC->SSSS: Loss of location at the melanosome membrane; when associated with S-16 and S-18."; /evidence="ECO:0000269|PubMed:22940130"; MUTAGEN 16; /note="C->S: Loss of location at the melanosome membrane; when associated with 11-SSSS-14 and S-18."; /evidence="ECO:0000269|PubMed:22940130"; MUTAGEN 18; /note="C->S: Loss of location at the melanosome membrane; when associated with 11-SSSS-14 and S-16."; /evidence="ECO:0000269|PubMed:22940130"; MUTAGEN 166; /note="Y->I: Loss of the ability to promote lysosome clustering at the center of the cell. No effect on location at lysosome membranes."; /evidence="ECO:0000269|PubMed:30174147"; MUTAGEN 177; /note="D->K: Mildly reduced ability to promote lysosome clustering at the center of the cell; when associated with K-180 and K-181."; /evidence="ECO:0000269|PubMed:30174147"; MUTAGEN 180; /note="E->K: Mildly reduced ability to promote lysosome clustering at the center of the cell; when associated with K-177 and K-181."; /evidence="ECO:0000269|PubMed:30174147"; MUTAGEN 181; /note="D->K: Mildly reduced ability to promote lysosome clustering at the center of the cell; when associated with K-177 and K-180."; /evidence="ECO:0000269|PubMed:30174147
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Palmitoylation is required to maintain the protein at the melanosome membrane. {ECO:0000269|PubMed:22940130}.
uniprot
proteins
protein_family
Melanoregulin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15550542
uniprot
proteins
pubmed
17260955
uniprot
proteins
pubmed
19240024
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22275436
uniprot
proteins
pubmed
22753477
uniprot
proteins
pubmed
22940130
uniprot
proteins
pubmed
30174147
uniprot
proteins
pubmed
3410303
uniprot
proteins
sequence_length
214
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:17260955}; Peripheral membrane protein {ECO:0000269|PubMed:17260955}. Melanosome membrane {ECO:0000269|PubMed:22275436, ECO:0000269|PubMed:22940130}; Lipid-anchor {ECO:0000269|PubMed:22940130}. Lysosome membrane {ECO:0000269|PubMed:22940130, ECO:0000269|PubMed:30174147}; Lipid-anchor {ECO:0000269|PubMed:22940130}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:19240024}. Note=Localizes to the inner segment and basal outer segment of rods in the retina. {ECO:0000269|PubMed:17260955}.
uniprot
proteins