EXO5
entrez
64789
canonical
uniprot
Q9H790
canonical
ensembl
ENSG00000164002
resolver
ensp
ENSP00000296380
resolver
ensp
ENSP00000351328
resolver
ensp
ENSP00000361788
resolver
ensp
ENSP00000391240
resolver
ensp
ENSP00000392115
resolver
ensp
ENSP00000398437
resolver
ensp
ENSP00000409715
resolver
ensp
ENSP00000413565
resolver
ensp
ENSP00000416857
resolver
ensp
ENSP00000508270
resolver
ensp
ENSP00000575639
resolver
ensp
ENSP00000575640
resolver
ensp
ENSP00000575641
resolver
ensp
ENSP00000575642
resolver
ensp
ENSP00000575643
resolver
ensp
ENSP00000575644
resolver
ensp
ENSP00000575645
resolver
ensp
ENSP00000575646
resolver
ensp
ENSP00000575647
resolver
ensp
ENSP00000575648
resolver
ensp
ENSP00000575649
resolver
ensp
ENSP00000575650
resolver
ensp
ENSP00000575651
resolver
ensp
ENSP00000575652
resolver
ensp
ENSP00000575653
resolver
ensp
ENSP00000575654
resolver
ensp
ENSP00000595799
resolver
ensp
ENSP00000595800
resolver
ensp
ENSP00000595801
resolver
ensp
ENSP00000595802
resolver
ensp
ENSP00000595803
resolver
ensp
ENSP00000595804
resolver
ensp
ENSP00000595805
resolver
ensp
ENSP00000595806
resolver
ensp
ENSP00000611562
resolver
ensp
ENSP00000611563
resolver
enst
ENST00000296380
resolver
enst
ENST00000358527
resolver
enst
ENST00000372703
resolver
enst
ENST00000415550
resolver
enst
ENST00000418186
resolver
enst
ENST00000419161
resolver
enst
ENST00000420209
resolver
enst
ENST00000432259
resolver
enst
ENST00000443729
resolver
enst
ENST00000682383
resolver
enst
ENST00000905580
resolver
enst
ENST00000905581
resolver
enst
ENST00000905582
resolver
enst
ENST00000905583
resolver
enst
ENST00000905584
resolver
enst
ENST00000905585
resolver
enst
ENST00000905586
resolver
enst
ENST00000905587
resolver
enst
ENST00000905588
resolver
enst
ENST00000905589
resolver
enst
ENST00000905590
resolver
enst
ENST00000905591
resolver
enst
ENST00000905592
resolver
enst
ENST00000905593
resolver
enst
ENST00000905594
resolver
enst
ENST00000905595
resolver
enst
ENST00000925740
resolver
enst
ENST00000925741
resolver
enst
ENST00000925742
resolver
enst
ENST00000925743
resolver
enst
ENST00000925744
resolver
enst
ENST00000925745
resolver
enst
ENST00000925746
resolver
enst
ENST00000925747
resolver
enst
ENST00000941503
resolver
enst
ENST00000941504
resolver
genesymbol
EXO5
resolver
genesymbol_syn
C1orf176
resolver
genesymbol_syn
DEM1
resolver
hgnc
HGNC:26115
resolver
uniprot
D3DPV4
resolver
uniprot
Q5SWM7
resolver
uniprot
Q5SWM8
resolver
uniprot
Q5SWM9
resolver
uniprot
Q5SWN0
resolver
uniprot
Q5SWN1
resolver
uniprot
Q8WTW9
resolver
uniprot_entry
EXO5_HUMAN
resolver
uniprot_sec
D3DPV4
resolver
uniprot_sec
Q5SWM7
resolver
uniprot_sec
Q5SWM8
resolver
uniprot_sec
Q5SWM9
resolver
uniprot_sec
Q5SWN0
resolver
uniprot_sec
Q5SWN1
resolver
uniprot_sec
Q8WTW9
resolver
amino_acid_sequence
MAETREEETVSAEASGFSDLSDSEFLEFLDLEDAQESKALVNMPGPSSESLGKDDKPISLQNWKRGLDILSPMERFHLKYLYVTDLATQNWCELQTAYGKELPGFLAPEKAAVLDTGASIHLARELELHDLVTVPVTTKEDAWAIKFLNILLLIPTLQSEGHIREFPVFGEGEGVLLVGVIDELHYTAKGELELAELKTRRRPMLPLEAQKKKDCFQVSLYKYIFDAMVQGKVTPASLIHHTKLCLEKPLGPSVLRHAQQGGFSVKSLGDLMELVFLSLTLSDLPVIDILKIEYIHQETATVLGTEIVAFKEKEVRAKVQHYMAYWMGHREPQGVDVEEAWKCRTCTYADICEWRKGSGVLSSTLAPQVKKAK
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity. {ECO:0000269|PubMed:23095756, ECO:0000269|PubMed:31563844}.
uniprot
proteins
mass_dalton
41816
uniprot
proteins
mutagenesis
MUTAGEN 196; /note="E->A: Nearly abolishes exonuclease activity."; /evidence="ECO:0000269|PubMed:23095756"; MUTAGEN 343; /note="C->A: Abolishes iron-sulfur-binding and affects exonuclease activity; when associated with A-346."; /evidence="ECO:0000269|PubMed:23095756"; MUTAGEN 346; /note="C->A: Abolishes iron-sulfur-binding and affects exonuclease activity; when associated with A-343."; /evidence="ECO:0000269|PubMed:23095756
uniprot
proteins
protein_family
EXO5 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
23095756
uniprot
proteins
pubmed
31563844
uniprot
proteins
pubmed
34197737
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23095756}. Cytoplasm, cytosol {ECO:0000269|PubMed:23095756}. Note=Localizes to repair foci in response to DNA damage.
uniprot
proteins