PVR
entrez
5817
canonical
uniprot
P15151
canonical
ensembl
ENSG00000073008
resolver
ensp
ENSP00000340870
resolver
ensp
ENSP00000383907
resolver
ensp
ENSP00000385344
resolver
ensp
ENSP00000402060
resolver
enst
ENST00000406449
resolver
enst
ENST00000425690
resolver
genesymbol
PVR
resolver
genesymbol_syn
PVS
resolver
hgnc
HGNC:9705
resolver
uniprot
A0A0A0MSA9
resolver
uniprot
A0A0C4DG49
resolver
uniprot
A8K4I1
resolver
uniprot
B4DTS9
resolver
uniprot
P15152
resolver
uniprot
Q15267
resolver
uniprot
Q15268
resolver
uniprot
Q96BJ1
resolver
uniprot_entry
A0A0A0MSA9_HUMAN
resolver
uniprot_entry
A0A0C4DG49_HUMAN
resolver
uniprot_entry
A8K4I1_HUMAN
resolver
uniprot_entry
PVR_HUMAN
resolver
uniprot_sec
B4DTS9
resolver
uniprot_sec
P15152
resolver
uniprot_sec
Q15267
resolver
uniprot_sec
Q15268
resolver
uniprot_sec
Q96BJ1
resolver
amino_acid_sequence
MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGISRNAIIFLVLGILVFLILLGIGIYFYWSKCSREVLWHCHLCPSSTEHASASANGHVSYSAVSRENSSSQDPQTEGTR
uniprot
proteins
function
FUNCTION: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. {ECO:0000269|PubMed:15471548, ECO:0000269|PubMed:15607800}.; FUNCTION: (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. {ECO:0000269|PubMed:2538245}.; FUNCTION: (Microbial infection) Acts as a receptor for Pseudorabies virus. {ECO:0000269|PubMed:9616127}.; FUNCTION: (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells. {ECO:0000269|PubMed:15640804}.
uniprot
proteins
mass_dalton
45303
uniprot
proteins
mutagenesis
MUTAGEN 369..372; /note="KCSR->ACSA: Partial loss of DYNLT1 binding."; /evidence="ECO:0000269|PubMed:15194795
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4. {ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22171320}.; PTM: Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is required for Phosphorylation. {ECO:0000269|PubMed:15194502, ECO:0000269|PubMed:22421438}.
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
10618374
uniprot
proteins
pubmed
11437656
uniprot
proteins
pubmed
11751937
uniprot
proteins
pubmed
11983699
uniprot
proteins
pubmed
12663789
uniprot
proteins
pubmed
12759359
uniprot
proteins
pubmed
1331527
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15034010
uniprot
proteins
pubmed
15039383
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15194502
uniprot
proteins
pubmed
15194795
uniprot
proteins
pubmed
15471548
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15607800
uniprot
proteins
pubmed
15640804
uniprot
proteins
pubmed
16216929
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
1851992
uniprot
proteins
pubmed
19011627
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
2170108
uniprot
proteins
pubmed
22171320
uniprot
proteins
pubmed
22421438
uniprot
proteins
pubmed
2538245
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9616127
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Delta]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Beta]: Secreted.; SUBCELLULAR LOCATION: [Isoform Gamma]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 344..367; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins