Doc2b
entrez
13447
canonical
uniprot
P70169
canonical
ensembl
ENSMUSG00000020848
resolver
ensp
ENSMUSP00000021209
resolver
enst
ENSMUST00000021209
resolver
genesymbol
Doc2b
resolver
uniprot
Q5SS41
resolver
uniprot
Q6NXK3
resolver
uniprot_entry
DOC2B_MOUSE
resolver
uniprot_sec
Q5SS41
resolver
uniprot_sec
Q6NXK3
resolver
amino_acid_sequence
MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPTAAPRAPAPPDAPARSPAASASPRSPSDGARDDDEDVDQLFGAYGASPGPSPGPSPARPPAKPPEDEPDVDGYESDDCTALGTLDFSLLYDQENNALHCTISKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPSWNETLTYYGITDEDMVRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKAEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLKPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKTLEVTVWDYDIGKSNDFIGGVVLGINAKGERLKHWFDCLKNKDKRIERWHTLTNELPGAVLSD
uniprot
proteins
function
FUNCTION: Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes. {ECO:0000269|PubMed:19033398, ECO:0000269|PubMed:19410553, ECO:0000269|PubMed:20150444, ECO:0000269|PubMed:8902635}.
uniprot
proteins
mass_dalton
45853
uniprot
proteins
mutagenesis
MUTAGEN 157; /note="D->N: Loss of interaction with STX4 and insulin-dependent translocation to the cell membrane; when associated with N-163, N-297 and N-303."; /evidence="ECO:0000269|PubMed:19033398"; MUTAGEN 163; /note="D->N: Loss of interaction with STX4 and insulin-dependent translocation to the cell membrane; when associated with N-157, N-297 and N-303."; /evidence="ECO:0000269|PubMed:19033398"; MUTAGEN 297; /note="D->N: Loss of interaction with STX4 and insulin-dependent translocation to the cell membrane; when associated with N-157, N-163 and N-303."; /evidence="ECO:0000269|PubMed:19033398"; MUTAGEN 303; /note="D->N: Loss of interaction with STX4 and insulin-dependent translocation to the cell membrane; when associated with N-157, N-163 and N-297."; /evidence="ECO:0000269|PubMed:19033398
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17548353
uniprot
proteins
pubmed
18596155
uniprot
proteins
pubmed
19033398
uniprot
proteins
pubmed
19410553
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20150444
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8902635
uniprot
proteins
sequence_length
412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic granule. Cell membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane in a calcium-dependent manner.
uniprot
proteins