COLEC11
entrez
78989
canonical
uniprot
Q9BWP8
canonical
ensembl
ENSG00000118004
resolver
ensp
ENSP00000236693
resolver
ensp
ENSP00000339168
resolver
ensp
ENSP00000371494
resolver
ensp
ENSP00000384882
resolver
ensp
ENSP00000385130
resolver
ensp
ENSP00000385653
resolver
ensp
ENSP00000385827
resolver
ensp
ENSP00000411770
resolver
ensp
ENSP00000526398
resolver
ensp
ENSP00000526401
resolver
genesymbol
COLEC11
resolver
hgnc
HGNC:17213
resolver
uniprot
A1IGE4
resolver
uniprot
A1IGE5
resolver
uniprot
A1IGE6
resolver
uniprot
A7VJJ2
resolver
uniprot
A7VJJ3
resolver
uniprot
A7VJJ4
resolver
uniprot
A7VJJ5
resolver
uniprot
B2R9M5
resolver
uniprot
B4E1G0
resolver
uniprot
J3KQY9
resolver
uniprot
Q5CZ85
resolver
uniprot
Q7Z6N1
resolver
uniprot_entry
COL11_HUMAN
resolver
uniprot_sec
A1IGE4
resolver
uniprot_sec
A1IGE5
resolver
uniprot_sec
A1IGE6
resolver
uniprot_sec
A7VJJ2
resolver
uniprot_sec
A7VJJ3
resolver
uniprot_sec
A7VJJ4
resolver
uniprot_sec
A7VJJ5
resolver
uniprot_sec
B2R9M5
resolver
uniprot_sec
B4E1G0
resolver
uniprot_sec
J3KQY9
resolver
uniprot_sec
Q5CZ85
resolver
uniprot_sec
Q7Z6N1
resolver
amino_acid_sequence
MRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGDAGEKGDKGAPGRPGRVGPTGEKGDMGDKGQKGSVGRHGKIGPIGSKGEKGDSGDIGPPGPNGEPGLPCECSQLRKAIGEMDNQVSQLTSELKFIKNAVAGVRETESKIYLLVKEEKRYADAQLSCQGRGGTLSMPKDEAANGLMAAYLAQAGLARVFIGINDLEKEGAFVYSDHSPMRTFNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHTTMYFMCEFDKENM
uniprot
proteins
disease_involvement
DISEASE: 3MC syndrome 2 (3MC2) [MIM:265050]: A form of 3MC syndrome, an autosomal recessive disorder characterized by facial dysmorphism, craniosynostosis, learning disability, and genital, limb and vesicorenal anomalies. Facial features include hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. {ECO:0000269|PubMed:21258343, ECO:0000269|PubMed:25912189, ECO:0000269|PubMed:28301481}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Lectin that plays a role in innate immunity, apoptosis and embryogenesis (PubMed:21258343, PubMed:23954398, PubMed:25912189). Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope (PubMed:25912189). Primarily recognizes the terminal disaccharide of the glycan (PubMed:25912189). Also recognizes a subset of fucosylated glycans and lipopolysaccharides (PubMed:17179669, PubMed:25912189). Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 (PubMed:20956340, PubMed:25912189). Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis (PubMed:21258343, PubMed:28301481). {ECO:0000269|PubMed:17179669, ECO:0000269|PubMed:20956340, ECO:0000269|PubMed:21258343, ECO:0000269|PubMed:23954398, ECO:0000269|PubMed:25912189, ECO:0000269|PubMed:28301481, ECO:0000305|PubMed:20956340, ECO:0000305|PubMed:23954398}.
uniprot
proteins
mass_dalton
28665
uniprot
proteins
protein_family
COLEC10/COLEC11 family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17179669
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20956340
uniprot
proteins
pubmed
21258343
uniprot
proteins
pubmed
23954398
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25912189
uniprot
proteins
pubmed
28301481
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25912189}.
uniprot
proteins