Tmem165
entrez
364137
canonical
uniprot
Q4V899
canonical
ensembl
ENSRNOG00000002199
resolver
ensembl
ENSRNOG00055005236
resolver
ensembl
ENSRNOG00060018506
resolver
ensembl
ENSRNOG00065020675
resolver
ensp
ENSRNOP00000003010
resolver
ensp
ENSRNOP00055006349
resolver
ensp
ENSRNOP00060025841
resolver
ensp
ENSRNOP00065028153
resolver
enst
ENSRNOT00000003010
resolver
enst
ENSRNOT00055008396
resolver
enst
ENSRNOT00060031812
resolver
enst
ENSRNOT00065035029
resolver
genesymbol
Tmem165
resolver
genesymbol_syn
Tparl
resolver
uniprot_entry
TM165_RAT
resolver
amino_acid_sequence
MAASARGSGRAPTRRLLVLLLLPLLWAPAGVRAGPEEDLSHRNQEPPAPAQQLQPQPAAVQGLEPARAEKGFTPAAPVHTNREDAATQANLGFIHAFVAAISVIIVSELGDKTFFIAAIMAMRYNRLTVLAGAMLALALMTCLSVLFGYATTVIPRVYTYYVSTALFAIFGIRMLREGLKMSPDEGQEELEEVQAELKKKDEEFQRTKLLNGPDVETGTSTAIPQKKWLHFISPIFVQALTLTFLAEWGDRSQLTTIVLAAREDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTVTIIGGIVFLAFAFSALFISPESGF
uniprot
proteins
function
FUNCTION: Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway (By similarity). Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk (By similarity). The transport mechanism and stoichiometry remains to be elucidated (By similarity). {ECO:0000250|UniProtKB:P38301, ECO:0000250|UniProtKB:P52875, ECO:0000250|UniProtKB:Q9HC07}.
uniprot
proteins
mass_dalton
34810
uniprot
proteins
protein_family
GDT1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:P52875}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 89..109; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 152..172; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 228..248; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 267..287; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 299..319; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins