Gpr15lg
entrez
290595
canonical
uniprot
D3ZKM3
canonical
ensembl
ENSRNOG00000043342
resolver
ensembl
ENSRNOG00055010418
resolver
ensembl
ENSRNOG00060011121
resolver
ensembl
ENSRNOG00065020601
resolver
ensp
ENSRNOP00000060855
resolver
ensp
ENSRNOP00055014187
resolver
ensp
ENSRNOP00060014665
resolver
ensp
ENSRNOP00065028024
resolver
enst
ENSRNOT00000065460
resolver
enst
ENSRNOT00055017625
resolver
enst
ENSRNOT00060018809
resolver
enst
ENSRNOT00065034885
resolver
genesymbol
Gpr15lg
resolver
genesymbol_syn
Gpr15l
resolver
uniprot_entry
GP15L_RAT
resolver
amino_acid_sequence
MRLLTLSGLFFMLFLCLCVLSSEGRKRPAKFPKLRPCCHLSPRSKPITWKGNHTRPCRPCRKLESNSWVVPGALPQI
uniprot
proteins
function
FUNCTION: Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G protein-coupled receptor GPR15 (PubMed:28900043). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May regulate keratinocyte proliferation. In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (By similarity). {ECO:0000250|UniProtKB:Q6UWK7, ECO:0000269|PubMed:28900043}.; FUNCTION: Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus. {ECO:0000250|UniProtKB:Q6UWK7}.
uniprot
proteins
mass_dalton
8807
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
28900043
uniprot
proteins
sequence_length
77
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6UWK7}.
uniprot
proteins