Arfgap3
entrez
66251
canonical
uniprot
Q9D8S3
canonical
ensembl
ENSMUSG00000054277
resolver
ensp
ENSMUSP00000064893
resolver
ensp
ENSMUSP00000154712
resolver
ensp
ENSMUSP00000295459
resolver
ensp
ENSMUSP00000295460
resolver
enst
ENSMUST00000067215
resolver
enst
ENSMUST00000226124
resolver
genesymbol
Arfgap3
resolver
uniprot
A0A0R4J0T8
resolver
uniprot
Q544V6
resolver
uniprot
Q8BW06
resolver
uniprot
Q99KN8
resolver
uniprot_entry
A0A0R4J0T8_MOUSE
resolver
uniprot_entry
ARFG3_MOUSE
resolver
uniprot_sec
Q544V6
resolver
uniprot_sec
Q8BW06
resolver
uniprot_sec
Q99KN8
resolver
activity_regulation
ACTIVITY REGULATION: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2). {ECO:0000250|UniProtKB:Q9NP61}.
uniprot
proteins
amino_acid_sequence
MGDPSKQDILAIFKRLRSVPTNKVCFDCGAKNPSWASISYGVFLCIDCSGSHRSLGVHLSFIRSTELDSNWSWFQLRCMQVGGNSNASSFFHQHGCATKDTNAKYNSRAAQLYREKIKTLATQATRRHGTDLWLDSCAAPPVSPPPKEEDFFASHASLEVSGAMQASAQPESASSTPWGLETTPEKHEGGPGQGPSVEGLNTPGKAAPEVSSIIKKKPNQAKKGLGAKKGSLGAQKLTNTSFTEIEKQAQAVDKRKEQEDLARGAPKEESIVSSLRLAYKDLEISRKKDERLNLSGQKKVEAERLGMGFGSCRSGISHSVTSDMQTIEQESPTLAKPRRKYQEDPEDSYFSSSSKWSEQSSRYFDDPMELRSSSFSSWDDGADSYWKKDSSRDPEPAMRSTGSSDRPSARRKPEYEPIGSTDEAQKKFGNVKAISSDMYFGIQAQTDFETRARLERLSTSSSISSADLFDEQRKQTAGNYNLSNVLPNAPDMAQFKQGVRSVAGKLSVFANGVMTSIQDRYGS
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1), which is essential for COPI vesicle formation and retrograde transport between the Golgi and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP leads to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. Promotes the proper assembly of the COPI coat lattice, rather than just acting as a simple curvature-dependent GAP like ARFGAP1. {ECO:0000250|UniProtKB:Q9NP61}.
uniprot
proteins
mass_dalton
57456
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9NP61}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NP61}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9NP61}. Cytoplasm {ECO:0000250|UniProtKB:Q9NP61}. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment. {ECO:0000250|UniProtKB:Q9NP61}.
uniprot
proteins