Mtmr4
entrez
170749
canonical
uniprot
Q91XS1
canonical
ensembl
ENSMUSG00000018401
resolver
ensp
ENSMUSP00000090478
resolver
ensp
ENSMUSP00000099468
resolver
ensp
ENSMUSP00000112902
resolver
ensp
ENSMUSP00000182628
resolver
ensp
ENSMUSP00000182629
resolver
ensp
ENSMUSP00000182630
resolver
ensp
ENSMUSP00000182632
resolver
ensp
ENSMUSP00000182633
resolver
ensp
ENSMUSP00000182634
resolver
ensp
ENSMUSP00000182635
resolver
genesymbol
Mtmr4
resolver
uniprot
Q5ND06
resolver
uniprot
Q5ND08
resolver
uniprot_entry
MTMR4_MOUSE
resolver
uniprot_sec
Q5ND06
resolver
uniprot_sec
Q5ND08
resolver
amino_acid_sequence
MGEEGPPSLEYIQAKDLFPPKELVKEEENLQVPFTVLQGEGVEFLGRATDALIAISNYRLHIKFKDSVINVPLRMIDSVESRDMFQLHIACKDSKVVRCHFSTFKQCQEWLSRLSRATARPAKPEDLFAFAYHAWCLGLTEEDQHTHLCQPGEHIRCRQEAELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRASGGSLSTGTNDASEACDTDFDSSLTACSGVESTAAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVLFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENAEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPGSDVVLHPVCHVRALHLWTAVYLPASSPCTLGEENMDLYLSPVAQSQEFSGRSLDRLPKTRSMDDLLSACDTSSPLTRTSSDPNLNNHSQEVRGSLEPWHSSPEGAETVIDSGVGSPQLTVGEMGLPPPLPSSQKEYLSNKPFKGHKSCSLSYKLLNTSVSWEMKSNTSDIKVLEETEALAPDPSAQEEQGRTSDGLGKPPEQFLEKEAVSSLCSVSSKCGGACDFPEPPQDPLTGTPQQPHLDSMQISPSRCTPDHSQGSLCNPPSVASQTPEPNTDLLSQDPPGSTASISHQEQPSSVPDLIYKKEDAGKRGSKNGQLLENPRFGKMPLELARKPISQSQISEFSFLGSNWDSFQGMMTSFPSGETTPRRLLAYGCCSKRPSNKHIRAAGPCLGGQWAQREGMKSPVCSSHSNGHCTGPGGKNNRMWFSSHPKQVSSTKPSLLSCPSPVPPLYLDDDGLPFPTDVIQHRLRQIEAGYRQEVEQLRRQVRELQMRLDIRHCCAPPAEPPMDYEDDFTCLKESDGSDTEDFGSDHSEDCLSEASWEPVDKKETEVTRWVPDHMASHCFNCDCEFWLAKRRHHCRNCGNVFCAGCCHLKLPIPDQQLYDPVLVCNSCYEHIQVSRARELMSQHLKKPIATASS
uniprot
proteins
ec_number
3.1.3.95
uniprot
proteins
function
FUNCTION: Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic, in a subset of endosomal membranes to negatively regulate both endocytic recycling and trafficking and/or maturation of endosomes toward lysosomes. Through phosphatidylinositol 3-phosphate turnover in phagosome membranes regulates phagocytosis and phagosome maturation. By decreasing phosphatidylinositol 3-monophosphate (PI3P) levels in immune cells it can also regulate the innate immune response. Beside its lipid phosphatase activity, can also function as a molecular adapter to regulate midbody abscission during mitotic cytokinesis. Can also negatively regulate TGF-beta and BMP signaling through Smad proteins dephosphorylation and retention in endosomes. {ECO:0000250|UniProtKB:Q9NYA4}.
uniprot
proteins
mass_dalton
132885
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination by NEDD4 probably leads to proteasomal degradation. {ECO:0000250|UniProtKB:Q9NYA4}.; PTM: Phosphorylated by CDK1 during mitosis. {ECO:0000250|UniProtKB:Q9NYA4}.
uniprot
proteins
protein_family
Non-receptor class myotubularin subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1190
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:Q9NYA4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NYA4}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9NYA4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NYA4}. Late endosome membrane {ECO:0000250|UniProtKB:Q9NYA4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NYA4}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9NYA4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NYA4}.
uniprot
proteins