Cep72
entrez
74470
canonical
uniprot
Q9D3R3
canonical
ensembl
ENSMUSG00000021572
resolver
ensp
ENSMUSP00000037788
resolver
ensp
ENSMUSP00000152641
resolver
ensp
ENSMUSP00000229590
resolver
ensp
ENSMUSP00000355602
resolver
genesymbol
Cep72
resolver
genesymbol_syn
Kiaa1519
resolver
uniprot
E9QQ95
resolver
uniprot
Q3TU12
resolver
uniprot
Q497H8
resolver
uniprot
Q69ZH7
resolver
uniprot
Q8BM53
resolver
uniprot
Q9D0B7
resolver
uniprot_entry
CEP72_MOUSE
resolver
uniprot_sec
E9QQ95
resolver
uniprot_sec
Q3TU12
resolver
uniprot_sec
Q497H8
resolver
uniprot_sec
Q69ZH7
resolver
uniprot_sec
Q8BM53
resolver
uniprot_sec
Q9D0B7
resolver
amino_acid_sequence
MAPGQRLVLCEETVRERSGLGPHRDLAELRSLSIPGTYQEKITHLGNSLMHLTALKSLDLSRNSLVSLEGIQYLVSLESLNLYYNCISSLAEVFRLHTLLELQDVDFRLNPVVKNESDYRLFVVHMLPKLRQLDDRPVRESERKASQLHFAPEDSLNSKENFSTTLTVGRPHHLRNRCTETSAKKCLVMDADDEAVLNLIAECEWDLSNPPGNMSSSQKEHEADLHYAQESRHLLSPLSIQHQCGDSARRGHEKKKVTSRGCPGHSPQDQLCGELPLQHGLPEACHMHVQHARITSQPDSVDVEDCASSAQKSSLSSQKTVNPLPVPEKYRKRRMPGGRFQVPSDRECLSFLERADGPSSLEDSLSRQDGLEGQSQVALSHSEALEAEERTSHGTSDPRVLSPKLCSAAVPERRSTLEVALLEALLDLIDRCSSGSGSLHGNEAFLAQAKHVLSSLQEFTATRDSSALEKEGIGYLSLENKTLQSRLAEQQQQYTATVTKMTAELNNTKRELDTLRQHLDKSLEENSHLKSLLYNVKKEVKTADTSTALTLQITGLQASMKQLSGEVVELKQHVEHYDKIQELTQMLQESHSSLVSTNEHLLQELSRTRAQHRAEVEQMRWSFQEFKKTTALIPHRSSRRGGRQSC
uniprot
proteins
function
FUNCTION: Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (By similarity). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (By similarity). {ECO:0000250|UniProtKB:Q9P209}.
uniprot
proteins
mass_dalton
72433
uniprot
proteins
protein_family
CEP72 family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
646
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9P209}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:Q9P209}. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q9P209}.
uniprot
proteins