Sod2
entrez
20656
canonical
uniprot
P09671
canonical
ensembl
ENSMUSG00000006818
resolver
ensp
ENSMUSP00000007012
resolver
enst
ENSMUST00000007012
resolver
genesymbol
Sod2
resolver
genesymbol_syn
Sod-2
resolver
uniprot
Q4FJX9
resolver
uniprot
Q64670
resolver
uniprot
Q8VEM5
resolver
uniprot_entry
Q4FJX9_MOUSE
resolver
uniprot_entry
SODM_MOUSE
resolver
uniprot_sec
Q64670
resolver
uniprot_sec
Q8VEM5
resolver
amino_acid_sequence
MLCRAACSTGRRLGPVAGAAGSRHKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNATEEKYHEALAKGDVTTQVALQPALKFNGGGHINHTIFWTNLSPKGGGEPKGELLEAIKRDFGSFEKFKEKLTAVSVGVQGSGWGWLGFNKEQGRLQIAACSNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYTACKK
uniprot
proteins
ec_number
1.15.1.1
uniprot
proteins
function
FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
uniprot
proteins
mass_dalton
24603
uniprot
proteins
mutagenesis
MUTAGEN 122; /note="K->R: Reverses IR-Induced increases in superoxide and genomic Instability in SIRT3-deficient mice."; /evidence="ECO:0000269|PubMed:21172655
uniprot
proteins
post_translational_modification
PTM: Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity (By similarity). {ECO:0000250|UniProtKB:P04179}.; PTM: Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting. {ECO:0000269|PubMed:21172655}.; PTM: Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability. {ECO:0000250|UniProtKB:P04179}.
uniprot
proteins
protein_family
Iron/manganese superoxide dismutase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20668652
uniprot
proteins
pubmed
21172655
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
3797253
uniprot
proteins
pubmed
7613035
uniprot
proteins
pubmed
7875582
uniprot
proteins
pubmed
8406027
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix.
uniprot
proteins