ICAM3
entrez
3385
canonical
uniprot
P32942
canonical
ensembl
ENSG00000076662
resolver
ensp
ENSP00000160262
resolver
ensp
ENSP00000516505
resolver
ensp
ENSP00000582601
resolver
enst
ENST00000160262
resolver
enst
ENST00000706691
resolver
genesymbol
ICAM3
resolver
hgnc
HGNC:5346
resolver
uniprot
A0A9L9PXS1
resolver
uniprot
Q6PD68
resolver
uniprot_entry
A0A9L9PXS1_HUMAN
resolver
uniprot_entry
ICAM3_HUMAN
resolver
uniprot_sec
Q6PD68
resolver
amino_acid_sequence
MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSSEKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMGEEPSRAE
uniprot
proteins
function
FUNCTION: Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring apoptotic neutrophil phagocytosis by macrophages (PubMed:1448173, PubMed:1448174, PubMed:23775590, PubMed:8325327, PubMed:8459213). Is also a ligand for integrin ITGAD/ITGB2 (PubMed:8777714). Ligand of CD209 on dendritic cells (DC) through an integrin-independent mechanism that requires Ca(2+) and that forms a first contact between DC and resting T cell, facilitating the downstream DC-T cell clustering process and DC-induced proliferation of resting T Cells (PubMed:10721994). {ECO:0000269|PubMed:10721994, ECO:0000269|PubMed:1448173, ECO:0000269|PubMed:1448174, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:8325327, ECO:0000269|PubMed:8459213, ECO:0000269|PubMed:8777714}.
uniprot
proteins
mass_dalton
59541
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains. {ECO:0000269|PubMed:15728350, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973}.
uniprot
proteins
protein_family
ICAM family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
10721994
uniprot
proteins
pubmed
11179968
uniprot
proteins
pubmed
1448173
uniprot
proteins
pubmed
1448174
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15728350
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23775590
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
8325327
uniprot
proteins
pubmed
8459213
uniprot
proteins
pubmed
8777714
uniprot
proteins
pubmed
9298994
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:8459213}; Single-pass type I membrane protein. Note=Localization at uropodium is mediated through interaction with MSN. {ECO:0000269|PubMed:9298994}.
uniprot
proteins
transmembrane_region
TRANSMEM 486..510; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins