Fdx2
entrez
68165
canonical
uniprot
Q9CPW2
canonical
ensembl
ENSMUSG00000079677
resolver
ensp
ENSMUSP00000010348
resolver
genesymbol
Fdx2
resolver
genesymbol_syn
Fdx1l
resolver
uniprot
Q6P8M0
resolver
uniprot
Q9CV00
resolver
uniprot_entry
FDX2_MOUSE
resolver
uniprot_sec
Q6P8M0
resolver
uniprot_sec
Q9CV00
resolver
amino_acid_sequence
MAASMARGVSARVLLRAAGGSWGPRAGHAAVTSRTFGTTGERRAGEEAADSPELPRDVVNVVFVDRSGKRIPVRGKVGDNVLYLAQRHGVDLEGACEASLACSTCHVYVSEAHLDLLPPPEEREDDMLDMAPLLQENSRLGCQIVLTPELEGVEFALPKITRNFYVDGHIPKPH
uniprot
proteins
function
FUNCTION: Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). Essential for coenzyme Q biosynthesis: together with FDXR, transfers the electrons required for the hydroxylation reaction performed by COQ6 (By similarity). {ECO:0000250|UniProtKB:Q6P4F2, ECO:0000250|UniProtKB:Q9H1K1}.
uniprot
proteins
mass_dalton
18766
uniprot
proteins
protein_family
Adrenodoxin/putidaredoxin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
174
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9H1K1}. Mitochondrion matrix {ECO:0000250|UniProtKB:P10109}.
uniprot
proteins