Chrna9
entrez
65024
canonical
uniprot
P43144
canonical
ensembl
ENSRNOG00000002484
resolver
ensp
ENSRNOP00000003382
resolver
enst
ENSRNOT00000003382
resolver
genesymbol
Chrna9
resolver
genesymbol_syn
Acra9
resolver
uniprot
Q6PW49
resolver
uniprot_entry
ACHA9_RAT
resolver
uniprot_sec
Q6PW49
resolver
activity_regulation
ACTIVITY REGULATION: Activated by a myriad of ligands such as acetylcholine (PubMed:10713500, PubMed:12117536). AChR activity is inhibited by the antagonist alpha-conotoxins RgIA and GeXXA, small disulfide-constrained peptides from cone snails (PubMed:22774872, PubMed:25740413). {ECO:0000269|PubMed:10713500, ECO:0000269|PubMed:12117536, ECO:0000269|PubMed:22774872, ECO:0000269|PubMed:25740413}.
uniprot
proteins
amino_acid_sequence
MNRPHSCLSFCWMYFAASGIRAVETANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD
uniprot
proteins
function
FUNCTION: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:7954834). Forms either homopentamers or heteropentamers with CHRNA10. Expressed in the inner ear, in sympathetic neurons and in other non-neuronal cells, such as skin keratinocytes and lymphocytes (PubMed:11044723, PubMed:14742688). nAChR formed by CHRNA9:CHRNA10 mediate central nervous system control of auditory and vestibular sensory processing. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:10713500, PubMed:11248107, PubMed:12117536). In the ear, mediates synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma (PubMed:11248107). May also regulate keratinocyte adhesion (By similarity). {ECO:0000250|UniProtKB:Q9UGM1, ECO:0000269|PubMed:10713500, ECO:0000269|PubMed:11044723, ECO:0000269|PubMed:11248107, ECO:0000269|PubMed:12117536, ECO:0000269|PubMed:14742688, ECO:0000269|PubMed:7954834}.
uniprot
proteins
mass_dalton
54526
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="S->N: No significant change in potency of inhibition of the CHRNA9:CHRNA10 receptor by the alpha-conotoxin RgIA."; /evidence="ECO:0000269|PubMed:22774872"; MUTAGEN 44; /note="S->N: No significant change in potency of inhibition of the CHRNA9:CHRNA10 receptorby the alpha-conotoxin RgIA."; /evidence="ECO:0000269|PubMed:22774872"; MUTAGEN 54; /note="A->K: No significant change in potency of inhibition of the CHRNA9:CHRNA10 receptorby the alpha-conotoxin RgIA."; /evidence="ECO:0000269|PubMed:22774872"; MUTAGEN 86; /note="T->E: The CHRNA9:CHRNA10 receptor is 20-fold less potently inhibited by the alpha-conotoxin RgIA."; /evidence="ECO:0000269|PubMed:25740413"; MUTAGEN 86; /note="T->I: The CHRNA9:CHRNA10 receptor is 1700-fold less potently inhibited by the alpha-conotoxin RgIA."; /evidence="ECO:0000269|PubMed:22774872, ECO:0000269|PubMed:25740413"; MUTAGEN 101; /note="R->G: No significant change in potency of inhibition of the CHRNA9:CHRNA10 receptor by the alpha-conotoxin RgIA."; /evidence="ECO:0000269|PubMed:22774872"; MUTAGEN 146; /note="D->L: Complete loss of inhibition of the CHRNA9:CHRNA10 receptor by the alpha-conotoxin RgIA."; /evidence="ECO:0000269|PubMed:25740413"; MUTAGEN 147; /note="S->A: No significant change in potency of inhibition of the CHRNA9:CHRNA10 receptor by the alpha-conotoxin RgIA."; /evidence="ECO:0000269|PubMed:22774872"; MUTAGEN 166; /note="S->N: No significant change in potency of inhibition of the CHRNA9:CHRNA10 receptor by the alpha-conotoxin RgIA."; /evidence="ECO:0000269|PubMed:22774872"; MUTAGEN 176; /note="W->T: The CHRNA9:CHRNA10 receptor is 8.5-fold less potently inhibited by the alpha-conotoxin RgIA."; /evidence="ECO:0000269|PubMed:18295795
uniprot
proteins
protein_family
Acetylcholine receptor (TC 1.A.9.1) subfamily
uniprot
proteins
protein_family
Alpha-9/CHRNA9 sub-subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
10713500
uniprot
proteins
pubmed
11044723
uniprot
proteins
pubmed
11248107
uniprot
proteins
pubmed
12117536
uniprot
proteins
pubmed
12401316
uniprot
proteins
pubmed
14742688
uniprot
proteins
pubmed
16306403
uniprot
proteins
pubmed
18295795
uniprot
proteins
pubmed
22774872
uniprot
proteins
pubmed
25740413
uniprot
proteins
pubmed
27559150
uniprot
proteins
pubmed
7954834
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:10713500, ECO:0000269|PubMed:11248107, ECO:0000269|PubMed:12117536, ECO:0000269|PubMed:7954834}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 238..262; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 269..287; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 302..323; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 458..476; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins