Amotl2
entrez
65157
canonical
uniprot
G3V735
canonical
ensembl
ENSRNOG00000008487
resolver
ensembl
ENSRNOG00055013354
resolver
ensembl
ENSRNOG00060008481
resolver
ensembl
ENSRNOG00065007788
resolver
ensp
ENSRNOP00000075540
resolver
ensp
ENSRNOP00000093935
resolver
ensp
ENSRNOP00055018557
resolver
ensp
ENSRNOP00060010875
resolver
ensp
ENSRNOP00065008949
resolver
enst
ENSRNOT00000094404
resolver
enst
ENSRNOT00055022894
resolver
enst
ENSRNOT00060014177
resolver
enst
ENSRNOT00065012229
resolver
genesymbol
Amotl2
resolver
uniprot
A0A8I6AGR3
resolver
uniprot_entry
A0A8I6AGR3_RAT
resolver
uniprot_entry
AMOL2_RAT
resolver
amino_acid_sequence
MRTLEDSSGTVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAGAGGTGSPQASLEIGAPEDSQVLQQATRQEPQGQEHQGGETHLAENRLYRLCPQPSKGEELPTYEEAKAHSQYYAAQQAGSRLHGGDRDPRGASGGSRRQDEALRELRHGHVRSLSERLLQLSLERNGARVPSHMSSSHSFPQLARSQQGPQPRGPPAEGPEPRGPPPQYPHAVMAQETAAVNDPRYRPRSSPHFQHAEVRILQAQVPPVFLQQQQYQYLQQPQEHSPPLHPAALGHGPPSSFSPPALEGPPGAQATSGSAHLAQMESVLRENARLQRDNERLQRELESTSEKASCIEKLENEIQRLSEAHESLMRTSSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRHLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQSRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQTGTLTGGGGSHTGSTELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLAGNHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRKDPGKATQGTLRPAKSVPSIFAAAVGTQGWQGFSTSERQTDAPARQTVDRGPAEEPPATPPLPAHTKHGSRDGSTQTDGPADSTSACLASEPDSLLGCNGSQRTTSLDSIAATRVQDLSDMVEILI
uniprot
proteins
function
FUNCTION: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (By similarity). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (By similarity). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (By similarity). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (By similarity). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (By similarity). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (By similarity). Selectively promotes FGF-induced MAPK activation through SRC (By similarity). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250, ECO:0000250|UniProtKB:Q8K371, ECO:0000250|UniProtKB:Q9Y2J4}.
uniprot
proteins
mass_dalton
85587
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated at Lys-342 and Lys-403 by Crumbs complex-bound WWP1 (By similarity). De-ubiquitinated at Lys-342 and Lys-403 by USP9X; the interaction may be promoted by cell contact inhibition (By similarity). Deubiquitination of AMOTL2 negatively regulates Hippo signaling activation (By similarity). {ECO:0000250|UniProtKB:Q9Y2J4}.; PTM: Phosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway. {ECO:0000250|UniProtKB:A1YB07}.
uniprot
proteins
protein_family
Angiomotin family
uniprot
proteins
sequence_length
773
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome {ECO:0000250|UniProtKB:A1YB07}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y2J4}. Cell projection, podosome {ECO:0000250|UniProtKB:Q8K371}. Cell junction {ECO:0000250|UniProtKB:Q8K371}.
uniprot
proteins