Pax4
entrez
83630
canonical
uniprot
O88436
canonical
ensembl
ENSRNOG00000008020
resolver
ensembl
ENSRNOG00055021207
resolver
ensembl
ENSRNOG00060028214
resolver
ensembl
ENSRNOG00065024865
resolver
ensp
ENSRNOP00000010658
resolver
genesymbol
Pax4
resolver
uniprot
O88437
resolver
uniprot
O88438
resolver
uniprot
O88439
resolver
uniprot_entry
PAX4_RAT
resolver
uniprot_sec
O88437
resolver
uniprot_sec
O88438
resolver
uniprot_sec
O88439
resolver
amino_acid_sequence
MQQDGLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGRYYRTGVLEPKGIGGSKPRLATPAVVARIAQLKDEYPALFAWEIQRQLCAEGLCTQDKAPSVSSINRVLRALQEDQRLHWTQLRSPAVLAPALPSPHSNCEAPRGPHPGTSHRNRTIFSPGQAEALEKEFQRGQYPDSVVRGKLAAATSLPEDTVRVWFSNRRAKWRRQEKLKWETQMPGASQDLMVPKDSPGIISAQQSPGSVPSAALPVLEQLNPSFCQLCWGAVPDRCSSDTTSQACLQPYWECHSLLPVASSSYMEFAWPCLTTHPVHHLIGGPGQAPSTYYLHWP
uniprot
proteins
function
FUNCTION: DNA-binding transcription factor that plays a central role in the differentiation and development of type B pancreatic cells, which are located within the pancreatic islets of Langerhans responsible for the production and release of insulin (By similarity). Mainly acts as a transcription repressor that binds to a common element in the glucagon, insulin and somatostatin promoters and inhibits their expression (By similarity). Prevents differentiation of type A pancreatic cells, probably by repressing expression of ARX (By similarity). Competes with another transcription factor, PAX6, for this same promoter binding site (By similarity). Also plays a key role in intestinal enteroendocrine cell differentiation by (1) directly promoting differentiation of enterochromaffin cells and (2) preventing differentiation of other intestinal enteroendocrine cell types (By similarity). Prevents differentiation of other intestinal enteroendocrine cell types by repressing the expression of ARX, the master transcription factor for intestinal type-L, -N, -D, -I and -G enteroendocrine cell differentiation (By similarity). {ECO:0000250|UniProtKB:O43316, ECO:0000250|UniProtKB:P32115}.
uniprot
proteins
mass_dalton
38485
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
10601637
uniprot
proteins
pubmed
9675102
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P32115}. Chromosome {ECO:0000250|UniProtKB:P32115}.
uniprot
proteins