CACNB2
entrez
783
canonical
uniprot
Q08289
canonical
ensembl
ENSG00000165995
resolver
ensp
ENSP00000282343
resolver
ensp
ENSP00000320025
resolver
ensp
ENSP00000344474
resolver
ensp
ENSP00000366532
resolver
ensp
ENSP00000366536
resolver
ensp
ENSP00000366546
resolver
ensp
ENSP00000379821
resolver
ensp
ENSP00000494209
resolver
ensp
ENSP00000495509
resolver
ensp
ENSP00000496203
resolver
ensp
ENSP00000498460
resolver
ensp
ENSP00000498938
resolver
enst
ENST00000650685
resolver
enst
ENST00000652391
resolver
genesymbol
CACNB2
resolver
genesymbol_syn
CACNLB2
resolver
genesymbol_syn
MYSB
resolver
hgnc
HGNC:1402
resolver
uniprot
A0A494C0B2
resolver
uniprot
A0A494C184
resolver
uniprot
A6PVM5
resolver
uniprot
A6PVM7
resolver
uniprot
A6PVM8
resolver
uniprot
O00304
resolver
uniprot
Q59H42
resolver
uniprot
Q5QJ99
resolver
uniprot
Q5QJA0
resolver
uniprot
Q5VVG9
resolver
uniprot
Q5VVH0
resolver
uniprot
Q5VVH1
resolver
uniprot
Q5VWV6
resolver
uniprot
Q6TME1
resolver
uniprot
Q6TME2
resolver
uniprot
Q6TME3
resolver
uniprot
Q8WX81
resolver
uniprot
Q96NZ3
resolver
uniprot
Q96NZ4
resolver
uniprot
Q96NZ5
resolver
uniprot
Q9BWU2
resolver
uniprot
Q9HD32
resolver
uniprot
Q9Y340
resolver
uniprot
Q9Y341
resolver
uniprot_entry
A0A494C0B2_HUMAN
resolver
uniprot_entry
A0A494C184_HUMAN
resolver
uniprot_entry
CACB2_HUMAN
resolver
uniprot_entry
Q59H42_HUMAN
resolver
uniprot_entry
Q5VVH1_HUMAN
resolver
uniprot_sec
A6PVM5
resolver
uniprot_sec
A6PVM7
resolver
uniprot_sec
A6PVM8
resolver
uniprot_sec
O00304
resolver
uniprot_sec
Q5QJ99
resolver
uniprot_sec
Q5QJA0
resolver
uniprot_sec
Q5VVG9
resolver
uniprot_sec
Q5VVH0
resolver
uniprot_sec
Q5VWV6
resolver
uniprot_sec
Q6TME1
resolver
uniprot_sec
Q6TME2
resolver
uniprot_sec
Q6TME3
resolver
uniprot_sec
Q8WX81
resolver
uniprot_sec
Q96NZ3
resolver
uniprot_sec
Q96NZ4
resolver
uniprot_sec
Q96NZ5
resolver
uniprot_sec
Q9BWU2
resolver
uniprot_sec
Q9HD32
resolver
uniprot_sec
Q9Y340
resolver
uniprot_sec
Q9Y341
resolver
amino_acid_sequence
MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ
uniprot
proteins
disease_involvement
DISEASE: Brugada syndrome 4 (BRGDA4) [MIM:611876]: A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. {ECO:0000269|PubMed:17224476}. Note=The gene represented in this entry may be involved in disease pathogenesis.
uniprot
proteins
function
FUNCTION: Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (PubMed:17525370). {ECO:0000250|UniProtKB:Q8CC27, ECO:0000250|UniProtKB:Q8VGC3, ECO:0000269|PubMed:17525370, ECO:0000269|PubMed:36424916}.
uniprot
proteins
mass_dalton
73581
uniprot
proteins
mutagenesis
MUTAGEN 298; /note="D->A: Reduces binding to RRAD; when associated with A-374 and A-376."; /evidence="ECO:0000269|PubMed:36424916"; MUTAGEN 374; /note="D->A: Reduces binding to RRAD; when associated with A-298 and A-376."; /evidence="ECO:0000269|PubMed:36424916"; MUTAGEN 376; /note="D->A: Reduces binding to RRAD; when associated with A-298 and A-374."; /evidence="ECO:0000269|PubMed:36424916
uniprot
proteins
post_translational_modification
PTM: Regulated through phosphorylation at Thr-554 by CaMK2D. {ECO:0000250}.
uniprot
proteins
protein_family
Calcium channel beta subunit family
uniprot
proteins
pubmed
12042350
uniprot
proteins
pubmed
14762176
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17224476
uniprot
proteins
pubmed
17525370
uniprot
proteins
pubmed
22419821
uniprot
proteins
pubmed
28130356
uniprot
proteins
pubmed
36424916
uniprot
proteins
pubmed
8494331
uniprot
proteins
pubmed
9254841
uniprot
proteins
sequence_length
660
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
uniprot
proteins