Nlrp5
entrez
23968
canonical
uniprot
Q9R1M5
canonical
ensembl
ENSMUSG00000015721
resolver
ensp
ENSMUSP00000015866
resolver
ensp
ENSMUSP00000083524
resolver
ensp
ENSMUSP00000104080
resolver
genesymbol
Nlrp5
resolver
genesymbol_syn
Mater
resolver
genesymbol_syn
Nalp5
resolver
uniprot
Q3UXD0
resolver
uniprot
Q53ZD5
resolver
uniprot
Q6VSF9
resolver
uniprot
Q6VSG0
resolver
uniprot
Q6VSG1
resolver
uniprot
Q6VSG2
resolver
uniprot
Q6VSG3
resolver
uniprot
Q6VSG4
resolver
uniprot
Q6VSG5
resolver
uniprot
Q6XZF2
resolver
uniprot
Q7TPU9
resolver
uniprot
Q9JLR2
resolver
uniprot_entry
NALP5_MOUSE
resolver
uniprot_sec
Q3UXD0
resolver
uniprot_sec
Q53ZD5
resolver
uniprot_sec
Q6VSF9
resolver
uniprot_sec
Q6VSG0
resolver
uniprot_sec
Q6VSG1
resolver
uniprot_sec
Q6VSG2
resolver
uniprot_sec
Q6VSG3
resolver
uniprot_sec
Q6VSG4
resolver
uniprot_sec
Q6VSG5
resolver
uniprot_sec
Q6XZF2
resolver
uniprot_sec
Q7TPU9
resolver
uniprot_sec
Q9JLR2
resolver
amino_acid_sequence
MGPPEKESKAILKARGLEEEQKSERKMTSPENDSKSIQKDQGPEQEQTSESTMGPPEKESKAILKARGLEEEQKSERKMTSPENDSKSIQKDQGPEQEQTSESTMGPPEKDSKAILKARGLEEEQKSESTMSPSENVSRAILKDSGSEEVEQASERKMTSPENDSKSIQKDQGPEQEQTSETLQSKEEDEVTEADKDNGGDLQDYKAHVIAKFDTSVDLHYDSPEMKLLSDAFKPYQKTFQPHTIILHGRPGVGKSALARSIVLGWAQGKLFQKMSFVIFFSVREIKWTEKSSLAQLIAKECPDSWDLVTKIMSQPERLLFVIDGLDDMDSVLQHDDMTLSRDWKDEQPIYILMYSLLRKALLPQSFLIITTRNTGLEKLKSMVVSPLYILVEGLSASRRSQLVLENISNESDRIQVFHSLIENHQLFDQCQAPSVCSLVCEALQLQKKLGKRCTLPCQTLTGLYATLVFHQLTLKRPSQSALSQEEQITLVGLCMMAAEGVWTMRSVFYDDDLKNYSLKESEILALFHMNILLQVGHNSEQCYVFSHLSLQDFFAALYYVLEGLEEWNQHFCFIENQRSIMEVKRTDDTRLLGMKRFLFGLMNKDILKTLEVLFEYPVIPTVEQKLQHWVSLIAQQVNGTSPMDTLDAFYCLFESQDEEFVGGALKRFQEVWLLINQKMDLKVSSYCLKHCQNLKAIRVDIRDLLSVDNTLELCPVVTVQETQCKPLLMEWWGNFCSVLGSLRNLKELDLGDSILSQRAMKILCLELRNQSCRIQKLTFKSAEVVSGLKHLWKLLFSNQNLKYLNLGNTPMKDDDMKLACEALKHPKCSVETLRLDSCELTIIGYEMISTLLISTTRLKCLSLAKNRVGVKSMISLGNALSSSMCLLQKLILDNCGLTPASCHLLVSALFSNQNLTHLCLSNNSLGTEGVQQLCQFLRNPECALQRLILNHCNIVDDAYGFLAMRLANNTKLTHLSLTMNPVGDGAMKLLCEALKEPTCYLQELELVDCQLTQNCCEDLACMITTTKHLKSLDLGNNALGDKGVITLCEGLKQSSSSLRRLGLGACKLTSNCCEALSLAISCNPHLNSLNLVKNDFSTSGMLKLCSAFQCPVSNLGIIGLWKQEYYARVRRQLEEVEFVKPHVVIDGDWYASDEDDRNWWKN
uniprot
proteins
function
FUNCTION: Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development (PubMed:11062459, PubMed:18804437, PubMed:25208553, PubMed:37922900, PubMed:41252458, PubMed:41845018, PubMed:41917274, PubMed:41986725). The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:37922900, PubMed:41845018, PubMed:41917274, PubMed:41986725). They are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained state, regulating their availability for early embryonic development (PubMed:37922900, PubMed:41252458, PubMed:41845018, PubMed:41917274, PubMed:41986725). Cytoplasmic lattices also tightly control ubiquitination during the oocyte-to-embryo transition by trapping E3 ubiquitin-protein ligase UHRF1 in a compact autoinhibited conformation and maintaining SCF ubiquitin ligase complexes inactive (PubMed:41845018, PubMed:41917274, PubMed:41986725). Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold (PubMed:31118423). Required for cortical actin clearance prior to oocyte exocytosis and prevention of polyspermy (PubMed:31118423). Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum storage (ER) storage via regulation of cellular localization (PubMed:24374158). May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation (PubMed:22357545). {ECO:0000269|PubMed:11062459, ECO:0000269|PubMed:18804437, ECO:0000269|PubMed:22357545, ECO:0000269|PubMed:24374158, ECO:0000269|PubMed:25208553, ECO:0000269|PubMed:31118423, ECO:0000269|PubMed:37922900, ECO:0000269|PubMed:41252458, ECO:0000269|PubMed:41845018, ECO:0000269|PubMed:41917274, ECO:0000269|PubMed:41986725}.
uniprot
proteins
mass_dalton
131318
uniprot
proteins
mutagenesis
MUTAGEN 425; /note="H->C: Impaired formation of the subcortical maternal complex (SCMC)."; /evidence="ECO:0000269|PubMed:38177687"; MUTAGEN 597; /note="R->C: Impaired formation of the subcortical maternal complex (SCMC)."; /evidence="ECO:0000269|PubMed:38177687"; MUTAGEN 602; /note="L->R: Impaired formation of the subcortical maternal complex (SCMC)."; /evidence="ECO:0000269|PubMed:38177687"; MUTAGEN 656; /note="S->I: Impaired formation of the subcortical maternal complex (SCMC)."; /evidence="ECO:0000269|PubMed:38177687"; MUTAGEN 729; /note="L->R: Decreased interaction with TLE6."; /evidence="ECO:0000269|PubMed:38177687"; MUTAGEN 737; /note="C->R: Decreased interaction with TLE6."; /evidence="ECO:0000269|PubMed:38177687"; MUTAGEN 910; /note="L->P: Decreased interaction with TLE6."; /evidence="ECO:0000269|PubMed:38177687"; MUTAGEN 1070; /note="T->I: Decreased interaction with TLE6."; /evidence="ECO:0000269|PubMed:38177687"; MUTAGEN 1077; /note="L->P: Decreased interaction with TLE6."; /evidence="ECO:0000269|PubMed:38177687"; MUTAGEN 1079; /note="L->W: Does not affect interaction with TLE6."; /evidence="ECO:0000269|PubMed:38177687
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKCE. {ECO:0000250|UniProtKB:P59047}.
uniprot
proteins
protein_family
NLRP family
uniprot
proteins
pubmed
10433232
uniprot
proteins
pubmed
10754103
uniprot
proteins
pubmed
11062459
uniprot
proteins
pubmed
12133995
uniprot
proteins
pubmed
14670992
uniprot
proteins
pubmed
15481533
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18057100
uniprot
proteins
pubmed
18804437
uniprot
proteins
pubmed
22357545
uniprot
proteins
pubmed
24374158
uniprot
proteins
pubmed
25208553
uniprot
proteins
pubmed
28992324
uniprot
proteins
pubmed
31118423
uniprot
proteins
pubmed
31575650
uniprot
proteins
pubmed
32731337
uniprot
proteins
pubmed
37922900
uniprot
proteins
pubmed
38177687
uniprot
proteins
pubmed
39379527
uniprot
proteins
pubmed
41118754
uniprot
proteins
pubmed
41252458
uniprot
proteins
pubmed
41845018
uniprot
proteins
pubmed
41917274
uniprot
proteins
pubmed
41986725
uniprot
proteins
sequence_length
1163
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14670992, ECO:0000269|PubMed:28992324, ECO:0000269|PubMed:31575650, ECO:0000269|PubMed:37922900, ECO:0000269|PubMed:41252458}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000269|PubMed:18057100}. Mitochondrion {ECO:0000269|PubMed:14670992}. Nucleus, nucleolus {ECO:0000269|PubMed:14670992}. Golgi apparatus {ECO:0000250|UniProtKB:P59047}. Note=Core component of cytoplasmic lattices in oocytes (PubMed:37922900). In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages (PubMed:14670992, PubMed:25208553). From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (PubMed:14670992). Expression largely disappears in blastocysts (PubMed:25208553). Located in mitochondria and nucleoli in primary follicle oocytes (PubMed:14670992). Colocalizes with ZBED3 and NLRP4F in the oocyte subcortex (PubMed:25208553, PubMed:28992324, PubMed:31575650). Not detected in oocyte mitochondria in type 2 follicles (PubMed:14670992). {ECO:0000269|PubMed:14670992, ECO:0000269|PubMed:25208553, ECO:0000269|PubMed:28992324, ECO:0000269|PubMed:31575650, ECO:0000269|PubMed:37922900}.
uniprot
proteins