Dennd10
entrez
67894
canonical
uniprot
Q9D8N2
canonical
ensembl
ENSMUSG00000024993
resolver
ensp
ENSMUSP00000025957
resolver
ensp
ENSMUSP00000112839
resolver
ensp
ENSMUSP00000162911
resolver
enst
ENSMUST00000025957
resolver
enst
ENSMUST00000119633
resolver
genesymbol
Dennd10
resolver
genesymbol_syn
Fam45a
resolver
uniprot
F6UAX9
resolver
uniprot
Q3TH34
resolver
uniprot
Q3UL11
resolver
uniprot
Q91WS5
resolver
uniprot_entry
DEN10_MOUSE
resolver
uniprot_entry
F6UAX9_MOUSE
resolver
uniprot_entry
Q3TH34_MOUSE
resolver
uniprot_sec
Q3UL11
resolver
uniprot_sec
Q91WS5
resolver
amino_acid_sequence
MAAVVAMDTQLMLGVGLIEKDSNGEALWVWCYPSTTASLRNLLLRKCCLTDENKLLHPFVFGQYRRTWFYVTTVEVPDSSVLKKVTHFSIVLTAKDFNPEKYAAFTRILCRIYLKYGSPVKMMESYIAVLTKGICQSEENGSFLSRDFDGRKAYLAGSIKDIVSQFGMETVILHTALMLKKRIVVYHPKIEAVQEFTRTLPALVWHRQDWTILHSYMHLHAEELEGLQMCTGYIAGFVELEVSNRPDLYDVFVNLADSEITIAPLAKEAMTMGKLHKEIGQLIVQSAEDPEKSDSQVIQDIALKTKEIFTHLAPFSEVSDDGGKVILNVEALKQQRFPPATENFLYHLAAAEQMLKV
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B (By similarity). Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP-bound form (By similarity). {ECO:0000250|UniProtKB:Q8TCE6}.
uniprot
proteins
mass_dalton
40421
uniprot
proteins
protein_family
DENND10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome {ECO:0000250|UniProtKB:Q8TCE6}.
uniprot
proteins