Tssk1b
entrez
22114
canonical
uniprot
Q61241
canonical
ensembl
ENSMUSG00000041566
resolver
ensp
ENSMUSP00000040302
resolver
enst
ENSMUST00000046937
resolver
genesymbol
Tssk1b
resolver
genesymbol_syn
Stk22a
resolver
genesymbol_syn
Tssk1
resolver
uniprot
Q80YU1
resolver
uniprot_entry
TSSK1_MOUSE
resolver
uniprot_sec
Q80YU1
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-174, potentially by autophosphorylation. {ECO:0000250|UniProtKB:Q9BXA7}.
uniprot
proteins
amino_acid_sequence
MDDAAVLKRRGYIMGINLGEGSYAKVKSAYSERLKFNVAVKIIDRKKAPSDFLEKFLPREIEILAMLNHRSIVKTYEIFETSDGKVYIVMELGVQGDLLEFIKTRGALQEDDARKKFHQLSSAIKYCHDLDVVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDDSGRLILSKTFCGSAAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYRMLQPDVNRRLHIDEILNHCWVQPKARGLSSGAINKEGESSRATEPSWIPEPGADKKSATKLEPREEARSEARSESKPQEDTLQVVRQSENVGLSSELNRDTEEGHPQQPSETHT
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Testis-specific serine/threonine-protein kinase required during spermatid development (PubMed:20053632, PubMed:23599433). Phosphorylates 'Ser-281' of TSKS (PubMed:20053632). Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm (PubMed:20053632). During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body (PubMed:20053632). {ECO:0000269|PubMed:20053632, ECO:0000269|PubMed:23599433}.
uniprot
proteins
mass_dalton
41589
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000250|UniProtKB:Q9BXA7}.; PTM: Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation. {ECO:0000269|PubMed:23599433}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10781952
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18533145
uniprot
proteins
pubmed
20053632
uniprot
proteins
pubmed
20729278
uniprot
proteins
pubmed
23599433
uniprot
proteins
pubmed
8112611
uniprot
proteins
pubmed
9412477
uniprot
proteins
pubmed
9651519
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. Note=In spermatozoa, present in the sperm head and in the flagellum.
uniprot
proteins