CATSPER2
entrez
117155
canonical
uniprot
Q96P56
canonical
ensembl
ENSG00000166762
resolver
ensp
ENSP00000321463
resolver
ensp
ENSP00000371180
resolver
ensp
ENSP00000380088
resolver
enst
ENST00000381761
resolver
genesymbol
CATSPER2
resolver
hgnc
HGNC:18810
resolver
uniprot
F8W9H2
resolver
uniprot
Q8NHT9
resolver
uniprot
Q96P54
resolver
uniprot
Q96P55
resolver
uniprot_entry
CTSR2_HUMAN
resolver
uniprot_entry
F8W9H2_HUMAN
resolver
uniprot_sec
Q8NHT9
resolver
uniprot_sec
Q96P54
resolver
uniprot_sec
Q96P55
resolver
activity_regulation
ACTIVITY REGULATION: The CatSper calcium channel is indirectly activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2 (PubMed:21412338, PubMed:21412339, PubMed:26989199). The CatSper calcium channel is directly inhibited by endocannabinoid 2-arachidonoylglycerol (2AG) (PubMed:26989199). Indirect activation by progesterone takes place via the following mechanism: progesterone binds and activates the acylglycerol lipase ABHD2, which in turn mediates hydrolysis of 2AG inhibitor, relieving inhibition of the CatSper channel (PubMed:26989199). The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers (PubMed:21412338, PubMed:21412339). Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH (PubMed:21412338, PubMed:21412339). {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339, ECO:0000269|PubMed:26989199}.
uniprot
proteins
amino_acid_sequence
MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGDQHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVSEVESNYGATEEDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPGLMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK
uniprot
proteins
disease_involvement
DISEASE: Deafness-infertility syndrome (DIS) [MIM:611102]: Characterized by deafness and infertility and is caused by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes. {ECO:0000269|PubMed:12825070, ECO:0000269|PubMed:17098888}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel, that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.
uniprot
proteins
mass_dalton
62041
uniprot
proteins
protein_family
Cation channel sperm-associated (TC 1.A.1.19) family
uniprot
proteins
pubmed
11675491
uniprot
proteins
pubmed
12825070
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16740636
uniprot
proteins
pubmed
17098888
uniprot
proteins
pubmed
17347248
uniprot
proteins
pubmed
21412338
uniprot
proteins
pubmed
21412339
uniprot
proteins
pubmed
26989199
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:A2ARP9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A2ARP9}.
uniprot
proteins
transmembrane_region
TRANSMEM 109..131; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:A2ARP9"; TRANSMEM 141..166; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:A2ARP9"; TRANSMEM 176..200; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:A2ARP9"; TRANSMEM 204..222; /note="Helical; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:A2ARP9"; TRANSMEM 240..262; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:A2ARP9"; TRANSMEM 315..341; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:A2ARP9
uniprot
proteins