Nabp1
entrez
109019
canonical
uniprot
Q8BGW5
canonical
ensembl
ENSMUSG00000026107
resolver
ensp
ENSMUSP00000027279
resolver
ensp
ENSMUSP00000140469
resolver
ensp
ENSMUSP00000140557
resolver
genesymbol
Nabp1
resolver
genesymbol_syn
Obfc2a
resolver
genesymbol_syn
Ssb2
resolver
uniprot
Q8C154
resolver
uniprot
Q8C164
resolver
uniprot_entry
SOSB2_MOUSE
resolver
uniprot_sec
Q8C154
resolver
uniprot_sec
Q8C164
resolver
amino_acid_sequence
MHGVNDPPLFIKDIKAGLKNLNVVFIVLEIGRVTKTKDGHEVRSCKVADRTGSITISVWDEIGGLIQTGDIIRLTRGYASMWKGCLTLYTGRGGELQKIGEFCMVYSEVPNFSEPNPDYRGQQNRGVQNEQKDKLSTNTFGPVGNGDQTGPESRGYHLPYGRSNGPGPISPQLPGTPSSQTVRTTISNARDPRRAFKR
uniprot
proteins
function
FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). {ECO:0000250, ECO:0000269|PubMed:16533169}.
uniprot
proteins
mass_dalton
21749
uniprot
proteins
protein_family
SOSS-B family
uniprot
proteins
protein_family
SOSS-B2 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16533169
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16533169}. Note=Localizes to nuclear foci following DNA damage. {ECO:0000250}.
uniprot
proteins