Rtn4
entrez
68585
canonical
uniprot
Q99P72
canonical
ensembl
ENSMUSG00000020458
resolver
ensp
ENSMUSP00000053754
resolver
ensp
ENSMUSP00000077875
resolver
ensp
ENSMUSP00000099905
resolver
ensp
ENSMUSP00000099906
resolver
ensp
ENSMUSP00000099907
resolver
genesymbol
Rtn4
resolver
genesymbol_syn
Kiaa0886
resolver
genesymbol_syn
Nogo
resolver
uniprot
Q5DTK9
resolver
uniprot
Q78NS1
resolver
uniprot
Q7TNB7
resolver
uniprot
Q80W95
resolver
uniprot
Q8BGK7
resolver
uniprot
Q8BGM9
resolver
uniprot
Q8BH78
resolver
uniprot
Q8BHF5
resolver
uniprot
Q8K290
resolver
uniprot
Q8K3G7
resolver
uniprot
Q8K3G8
resolver
uniprot
Q9CTE3
resolver
uniprot_entry
RTN4_MOUSE
resolver
uniprot_sec
Q5DTK9
resolver
uniprot_sec
Q78NS1
resolver
uniprot_sec
Q7TNB7
resolver
uniprot_sec
Q80W95
resolver
uniprot_sec
Q8BGK7
resolver
uniprot_sec
Q8BGM9
resolver
uniprot_sec
Q8BH78
resolver
uniprot_sec
Q8BHF5
resolver
uniprot_sec
Q8K290
resolver
uniprot_sec
Q8K3G7
resolver
uniprot_sec
Q8K3G8
resolver
uniprot_sec
Q9CTE3
resolver
amino_acid_sequence
MEDIDQSSLVSSSADSPPRPPPAFKYQFVTEPEDEEDEEDEEEEEDDEDLEELEVLERKPAAGLSAAPVPPAAAPLLDFSSDSVPPAPRGPLPAAPPTAPERQPSWERSPAASAPSLPPAAAVLPSKLPEDDEPPARPPAPAGASPLAEPAAPPSTPAAPKRRGSGSVDETLFALPAASEPVIPSSAEKIMDLKEQPGNTVSSGQEDFPSVLFETAASLPSLSPLSTVSFKEHGYLGNLSAVASTEGTIEETLNEASRELPERATNPFVNRESAEFSVLEYSEMGSSFNGSPKGESAMLVENTKEEVIVRSKDKEDLVCSAALHNPQESPATLTKVVKEDGVMSPEKTMDIFNEMKMSVVAPVREEYADFKPFEQAWEVKDTYEGSRDVLAARANMESKVDKKCFEDSLEQKGHGKDSESRNENASFPRTPELVKDGSRAYITCDSFSSATESTAANIFPVLEDHTSENKTDEKKIEERKAQIITEKTSPKTSNPFLVAIHDSEADYVTTDNLSKVTEAVVATMPEGLTPDLVQEACESELNEATGTKIAYETKVDLVQTSEAIQESIYPTAQLCPSFEEAEATPSPVLPDIVMEAPLNSLLPSTGASVAQPSASPLEVPSPVSYDGIKLEPENPPPYEEAMSVALKTSDSKEEIKEPESFNAAAQEAEAPYISIACDLIKETKLSTEPSPEFSNYSEIAKFEKSVPDHCELVDDSSPESEPVDLFSDDSIPEVPQTQEEAVMLMKESLTEVSETVTQHKHKERLSASPQEVGKPYLESFQPNLHITKDAASNEIPTLTKKETISLQMEEFNTAIYSNDDLLSSKEDKMKESETFSDSSPIEIIDEFPTFVSAKDDSPKEYTDLEVSNKSEIANVQSGANSLPCSELPCDLSFKNTYPKDEAHVSDEFSKSRSSVSKVPLLLPNVSALESQIEMGNIVKPKVLTKEAEEKLPSDTEKEDRSLTAVLSAELNKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNSTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSIPVIYERHQAQIDHYLGLANKSVKDAMAKIQAKIPGLKRKAE
uniprot
proteins
function
FUNCTION: Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities. {ECO:0000250|UniProtKB:Q9NQC3}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system (PubMed:20573699). Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (By similarity). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (PubMed:20573699). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (PubMed:23625008). {ECO:0000250|UniProtKB:Q9NQC3, ECO:0000269|PubMed:20573699, ECO:0000269|PubMed:23625008}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells (PubMed:15034570). Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P) (PubMed:26301690). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair (PubMed:19805174). Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation (PubMed:21183689). Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes (PubMed:25917084). Also involved in immune response to LPS (PubMed:26174362). Plays a role in liver regeneration through the modulation of hepatocytes proliferation (PubMed:23299899). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (By similarity). {ECO:0000250|UniProtKB:Q9NQC3, ECO:0000269|PubMed:15034570, ECO:0000269|PubMed:19805174, ECO:0000269|PubMed:21183689, ECO:0000269|PubMed:23299899, ECO:0000269|PubMed:25917084, ECO:0000269|PubMed:26174362, ECO:0000269|PubMed:26301690, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (PubMed:27763637). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (By similarity). {ECO:0000250|UniProtKB:Q9NQC3, ECO:0000269|PubMed:27763637}.
uniprot
proteins
mass_dalton
126613
uniprot
proteins
pubmed
12067236
uniprot
proteins
pubmed
12488097
uniprot
proteins
pubmed
15034570
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19805174
uniprot
proteins
pubmed
20093372
uniprot
proteins
pubmed
20573699
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21183689
uniprot
proteins
pubmed
23299899
uniprot
proteins
pubmed
23625008
uniprot
proteins
pubmed
25917084
uniprot
proteins
pubmed
26174362
uniprot
proteins
pubmed
26301690
uniprot
proteins
pubmed
27763637
uniprot
proteins
pubmed
27786289
uniprot
proteins
pubmed
32075961
uniprot
proteins
pubmed
35771867
uniprot
proteins
sequence_length
1162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform A]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27786289, ECO:0000269|PubMed:32075961}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9NQC3}; Multi-pass membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9NQC3}. Synapse {ECO:0000269|PubMed:35771867}. Note=Anchored to the membrane of the endoplasmic reticulum (ER) through 2 putative transmembrane domains. Localizes throughout the ER tubular network. Co-localizes with TMEM33 at the ER sheets. {ECO:0000250|UniProtKB:Q9NQC3}.; SUBCELLULAR LOCATION: [Isoform B]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25917084, ECO:0000269|PubMed:27786289, ECO:0000269|PubMed:32075961}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9NQC3}; Multi-pass membrane protein {ECO:0000255}; Extracellular side {ECO:0000250|UniProtKB:Q9NQC3}. Cell junction {ECO:0000250|UniProtKB:Q9NQC3}. Note=Mainly located on endoplasmic reticulum tubules and sheet edges (PubMed:27786289). Upon ICAM1 engagement, redistributed toward endothelial junctions where interacts with CDH5 (By similarity). {ECO:0000250|UniProtKB:Q9NQC3, ECO:0000269|PubMed:27786289}.; SUBCELLULAR LOCATION: [Isoform C]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NQC3}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 989..1009; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1079..1099; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins