ICMT
entrez
23463
canonical
uniprot
O60725
canonical
ensembl
ENSG00000116237
resolver
ensp
ENSP00000343552
resolver
ensp
ENSP00000466222
resolver
ensp
ENSP00000777370
resolver
enst
ENST00000343813
resolver
enst
ENST00000489498
resolver
genesymbol
ICMT
resolver
genesymbol_syn
PCCMT
resolver
hgnc
HGNC:5350
resolver
uniprot
A6NKX2
resolver
uniprot
B3KS61
resolver
uniprot
Q6FHT0
resolver
uniprot
Q7Z750
resolver
uniprot_entry
B3KS61_HUMAN
resolver
uniprot_entry
ICMT_HUMAN
resolver
uniprot_entry
Q7Z750_HUMAN
resolver
uniprot_sec
A6NKX2
resolver
uniprot_sec
Q6FHT0
resolver
activity_regulation
ACTIVITY REGULATION: Competitively inhibited by N-acetyl-S-trans,trans-farnesyl-l-cysteine (AFC). {ECO:0000269|PubMed:9614111}.
uniprot
proteins
amino_acid_sequence
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFTAGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
uniprot
proteins
ec_number
2.1.1.100
uniprot
proteins
function
FUNCTION: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. {ECO:0000269|PubMed:9614111}.
uniprot
proteins
mass_dalton
31938
uniprot
proteins
protein_family
Class VI-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Isoprenylcysteine carboxyl methyltransferase family
uniprot
proteins
pubmed
10649571
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19158273
uniprot
proteins
pubmed
9614111
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19158273, ECO:0000269|PubMed:9614111}; Multi-pass membrane protein {ECO:0000269|PubMed:19158273}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 42..59; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 70..87; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..112; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 132..149; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..174; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 213..228; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 230..244; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins