THAP5
entrez
168451
canonical
uniprot
Q7Z6K1
canonical
ensembl
ENSG00000177683
resolver
ensp
ENSP00000322440
resolver
ensp
ENSP00000400500
resolver
ensp
ENSP00000799382
resolver
genesymbol
THAP5
resolver
hgnc
HGNC:23188
resolver
uniprot_entry
THAP5_HUMAN
resolver
amino_acid_sequence
MPRYCAAICCKNRRGRNNKDRKLSFYPFPLHDKERLEKWLKNMKRDSWVPSKYQFLCSDHFTPDSLDIRWGIRYLKQTAVPTIFSLPEDNQGKDPSKKKSQKKNLEDEKEVCPKAKSEESFVLNETKKNIVNTDVPHQHPELLHSSSLVKPPAPKTGSIQNNMLTLNLVKQHTGKPESTLETSVNQDTGRGGFHTCFENLNSTTITLTTSNSESIHQSLETQEVLEVTTSHLANPNFTSNSMEIKSAQENPFLFSTINQTVEELNTNKESVIAIFVPAENSKPSVNSFISAQKETTEMEDTDIEDSLYKDVDYGTEVLQIEHSYCRQDINKEHLWQKVSKLHSKITLLELKEQQTLGRLKSLEALIRQLKQENWLSEENVKIIENHFTTYEVTMI
uniprot
proteins
function
FUNCTION: Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro) (PubMed:21110952). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase (PubMed:19502560). {ECO:0000269|PubMed:21110952, ECO:0000305|PubMed:19502560}.
uniprot
proteins
mass_dalton
45416
uniprot
proteins
post_translational_modification
PTM: Cleaved by HTRA2 during apoptosis. {ECO:0000269|PubMed:19502560}.
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19502560
uniprot
proteins
pubmed
21110952
uniprot
proteins
pubmed
21195082
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19502560, ECO:0000269|PubMed:21110952}.
uniprot
proteins