Arrdc3
entrez
105171
canonical
uniprot
Q7TPQ9
canonical
ensembl
ENSMUSG00000074794
resolver
ensp
ENSMUSP00000096957
resolver
ensp
ENSMUSP00000125455
resolver
enst
ENSMUST00000099356
resolver
enst
ENSMUST00000161441
resolver
genesymbol
Arrdc3
resolver
genesymbol_syn
Kiaa1376
resolver
uniprot
E0CZE1
resolver
uniprot
Q4KMN0
resolver
uniprot
Q80TE6
resolver
uniprot
Q8K0L7
resolver
uniprot_entry
ARRD3_MOUSE
resolver
uniprot_entry
E0CZE1_MOUSE
resolver
uniprot_sec
Q4KMN0
resolver
uniprot_sec
Q80TE6
resolver
uniprot_sec
Q8K0L7
resolver
amino_acid_sequence
MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLLLSLPLVIGTIPLHPFGSRTSSVSSQCSMSMNWLALALPERPEAPPSYAEVVTEEQRRNNLAPVGACDDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSSEDRPSCPSR
uniprot
proteins
function
FUNCTION: Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:21982743). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. {ECO:0000250|UniProtKB:Q96B67, ECO:0000305|PubMed:21982743}.
uniprot
proteins
mass_dalton
46275
uniprot
proteins
protein_family
Arrestin family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21982743
uniprot
proteins
sequence_length
414
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96B67}. Cell membrane {ECO:0000250|UniProtKB:Q96B67}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96B67}; Cytoplasmic side {ECO:0000250|UniProtKB:Q96B67}. Lysosome {ECO:0000250|UniProtKB:Q96B67}. Endosome {ECO:0000250|UniProtKB:Q96B67}. Early endosome {ECO:0000250|UniProtKB:Q96B67}. Note=Associated with plasma membrane, as well as with endosomes and lysosomes during endocytosis. {ECO:0000250|UniProtKB:Q96B67}.
uniprot
proteins