Gpsm1
entrez
246254
canonical
uniprot
Q9R080
canonical
ensembl
ENSRNOG00000018666
resolver
ensp
ENSRNOP00000062075
resolver
ensp
ENSRNOP00000089684
resolver
enst
ENSRNOT00000067840
resolver
enst
ENSRNOT00000102548
resolver
genesymbol
Gpsm1
resolver
genesymbol_syn
Ags3
resolver
uniprot
A0A8I6AC91
resolver
uniprot
G3V9X2
resolver
uniprot
Q8K3E2
resolver
uniprot_entry
A0A8I6AC91_RAT
resolver
uniprot_entry
G3V9X2_RAT
resolver
uniprot_entry
GPSM1_RAT
resolver
uniprot_sec
Q8K3E2
resolver
amino_acid_sequence
MASPAPPAAEELPGPAARRLYSRMEASCLELALEGERLCKAGDFKAGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEYARALQFHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAAQDPGHLPPDVRETLHRASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQIRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADRVGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQEIGDRNGELTARMNIAHLQLALGRLTSPAAAEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLDREQNGETHHTGDWRGPSRDSLPLPMRSRKYQEGPDAIERRPREGSHSPLDSADVRVQVPRTGIPRAPSSDEECFFDLLSKFQSSRMDDQRCPLEEGQAGAAEATAAPTLEERAAQPSVTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLRITLNNVGHLRGDGDPQEPGDEFFNMLIKYQSSRIDDQRCPPPDVLPRGPTMPDEDFFSLIQRVQAKRMDEQRVDLAGSPDQEASGLPDPRQQCPPGAS
uniprot
proteins
function
FUNCTION: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269|PubMed:10559191, ECO:0000269|PubMed:11042168, ECO:0000269|PubMed:11121039, ECO:0000269|PubMed:12834360, ECO:0000269|PubMed:14726514, ECO:0000269|PubMed:15091342, ECO:0000269|PubMed:15937104}.
uniprot
proteins
mass_dalton
74440
uniprot
proteins
mutagenesis
MUTAGEN 631; /note="F->R: Loss of interaction with GNAI2 and GNAI3."; /evidence="ECO:0000269|PubMed:10559191"; MUTAGEN 639; /note="Q->A: Loss of interaction with GNAI2 and GNAI3."; /evidence="ECO:0000269|PubMed:10559191"; MUTAGEN 647; /note="R->F: Loss of interaction with GNAI2 and GNAI3."; /evidence="ECO:0000269|PubMed:10559191
uniprot
proteins
post_translational_modification
PTM: Phosphorylation regulates interaction with G(i/o) alpha. {ECO:0000250}.
uniprot
proteins
protein_family
GPSM family
uniprot
proteins
pubmed
10559191
uniprot
proteins
pubmed
11042168
uniprot
proteins
pubmed
11121039
uniprot
proteins
pubmed
11278352
uniprot
proteins
pubmed
11832491
uniprot
proteins
pubmed
12719437
uniprot
proteins
pubmed
12834360
uniprot
proteins
pubmed
14726514
uniprot
proteins
pubmed
15091342
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15937104
uniprot
proteins
pubmed
16154268
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
673
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol. Note=Isoform 2 is not associated with membranes.
uniprot
proteins