Kdm2b
entrez
30841
canonical
uniprot
Q6P1G2
canonical
ensembl
ENSMUSG00000029475
resolver
ensp
ENSMUSP00000031435
resolver
ensp
ENSMUSP00000038229
resolver
ensp
ENSMUSP00000083376
resolver
ensp
ENSMUSP00000114049
resolver
ensp
ENSMUSP00000114052
resolver
enst
ENSMUST00000086200
resolver
genesymbol
Kdm2b
resolver
genesymbol_syn
Fbl10
resolver
genesymbol_syn
Fbxl10
resolver
genesymbol_syn
Jhdm1b
resolver
genesymbol_syn
Kiaa3014
resolver
uniprot
E9QL25
resolver
uniprot
Q3V396
resolver
uniprot
Q6PFD0
resolver
uniprot
Q6ZPE8
resolver
uniprot
Q9CSF7
resolver
uniprot
Q9QZN6
resolver
uniprot_entry
E9QL25_MOUSE
resolver
uniprot_entry
KDM2B_MOUSE
resolver
uniprot_sec
Q3V396
resolver
uniprot_sec
Q6PFD0
resolver
uniprot_sec
Q6ZPE8
resolver
uniprot_sec
Q9CSF7
resolver
uniprot_sec
Q9QZN6
resolver
activity_regulation
ACTIVITY REGULATION: Histone demethylase activity is inhibited by fumarate. {ECO:0000250|UniProtKB:Q8NHM5}.
uniprot
proteins
amino_acid_sequence
MEAEKDSGRRLRAIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLVFRDKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNALAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSYLTQEYQRELMLIDAPRKTSVDGFSSDSWLDMEEESCEQQPQEEEEEEEDKEEEGDGADKTPKPPTDDPTSPTSTPPEDQDSTGKKPKAPAIRFLKRTLSNESEESVKSTSMPTDDPKTPTGSPATEVSTKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHVDDDPTLAITGVPVVSWPKKTAKNRVVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHPKKVPADGILRRKSDDVHLRRKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRLSLANKPLRRFKQEPEDDLPEAPPKTRESDQSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLVNKELSKELSKELNHEIQKTESTLAHESQQPIKSEPESENDEPKRPLSHCERPHRFSKGLNGTPRELRHSLGPGLRSPPRVMSRPPPSASPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHRDLCVCMRVCRTWNRWCCDKRLWTRIDLNRCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDVSLRLIIRHMPLLSKLQLSYCNHINDQSINLLTAVGTTTRDSLTEVNLSDCNKVTDLCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSVSVQFGQVEEKLLQKLS
uniprot
proteins
ec_number
1.14.11.27
uniprot
proteins
function
FUNCTION: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (By similarity). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). {ECO:0000250|UniProtKB:Q8NHM5}.
uniprot
proteins
mass_dalton
149733
uniprot
proteins
protein_family
JHDM1 histone demethylase family
uniprot
proteins
pubmed
10531037
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8NHM5}. Nucleus {ECO:0000250|UniProtKB:Q8NHM5}. Chromosome {ECO:0000250|UniProtKB:Q8NHM5}.
uniprot
proteins