KCTD10
entrez
83892
canonical
uniprot
Q9H3F6
canonical
ensembl
ENSG00000110906
resolver
ensp
ENSP00000228495
resolver
ensp
ENSP00000441672
resolver
ensp
ENSP00000643420
resolver
ensp
ENSP00000748895
resolver
ensp
ENSP00000781713
resolver
genesymbol
KCTD10
resolver
genesymbol_syn
ULR061
resolver
hgnc
HGNC:23236
resolver
uniprot
Q53HN2
resolver
uniprot
Q59FV1
resolver
uniprot
Q6PL47
resolver
uniprot
Q96SU0
resolver
uniprot_entry
BACD3_HUMAN
resolver
uniprot_sec
Q53HN2
resolver
uniprot_sec
Q59FV1
resolver
uniprot_sec
Q6PL47
resolver
uniprot_sec
Q96SU0
resolver
amino_acid_sequence
MEEMSGESVVSSAVPAAATRTTSFKGTSPSSKYVKLNVGGALYYTTMQTLTKQDTMLKAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRDGAVPLPESRREIEELLAEAKYYLVQGLVEECQAALQNKDTYEPFCKVPVITSSKEEQKLIATSNKPAVKLLYNRSNNKYSYTSNSDDNMLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIYEETLNILLYEAQDGRGPDNALLEATGGAAGRSHHLDEDEERERIERVRRIHIKRPDDRAHLHQ
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of multiple substrates, leading to either their proteasomal or lysosomal degradation, or modulating their activity through non-degradative ubiquitination. Controls endothelial barrier function by mediating 'Lys-63'-linked polyubiquitination of RHOB, promoting its lysosomal degradation (PubMed:29358211). Mediates polyubiquitination of CEP97, targeting it for proteasomal degradation. CEP97 degradation upon serum starvation is essential for primary cilium formation by enabling removal of the CEP97-CP110 complex from mother centrioles (PubMed:30404837). Acts as a positive regulator of ferroptosis by destabilizing SLC7A11. Decreased SLC7A11 levels reduce cystine uptake and glutathione (GSH) biosynthesis, thereby promoting iron-dependent lipid peroxidation and ferroptotic cell death (PubMed:38959043). In the innate immune response, mediates 'Lys-27'-linked polyubiquitination of TICAM1/TRIF at Lys-523 upon stimulation with LPS. This ubiquitination is essential for recruitment of TICAM1 to TLR3/4, thereby promoting TLR3/4-mediated immune signaling (PubMed:31511519). Negatively regulates KCTD13 stability through the ubiquitin/proteasome degradation pathway within the developing brain to control neuronal progenitor cell proliferation and differentiation (By similarity). Acts as a sensor for co-directional transcription-replication conflicts, where it helps coordinate the interaction between the replication machinery and RNA polymerase to allow DNA replication to continue through actively transcribed regions. Promotes recruitment of ubiquitin ligase complexes that remove stalled transcription factors, thereby maintaining genome stability by resolving these conflicts. Ubiquitinates TCEA2 to remodel the RNAP complex (PubMed:41062692). {ECO:0000250|UniProtKB:Q922M3, ECO:0000269|PubMed:29358211, ECO:0000269|PubMed:30404837, ECO:0000269|PubMed:31511519, ECO:0000269|PubMed:38959043, ECO:0000269|PubMed:41062692}.
uniprot
proteins
mass_dalton
35432
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
BACURD family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19125419
uniprot
proteins
pubmed
19782033
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28963344
uniprot
proteins
pubmed
29358211
uniprot
proteins
pubmed
30404837
uniprot
proteins
pubmed
31511519
uniprot
proteins
pubmed
38959043
uniprot
proteins
pubmed
41062692
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19125419}.
uniprot
proteins