Cenpb
entrez
12616
canonical
uniprot
P27790
canonical
ensembl
ENSMUSG00000068267
resolver
ensp
ENSMUSP00000086938
resolver
enst
ENSMUST00000089510
resolver
genesymbol
Cenpb
resolver
genesymbol_syn
Cenp-b
resolver
uniprot
Q7TSG8
resolver
uniprot_entry
CENPB_MOUSE
resolver
uniprot_sec
Q7TSG8
resolver
amino_acid_sequence
MGPKRRQLTFREKSRIIQEVEENPDLRKGEIARRFNIPPSTLSTILKNKRAILASERKYGVASTCRKTNKLSPYDKLEGLLIAWFQQIRAAGLPVKGIILKEKALRIAEELGMDDFTASNGWLDRFRRRHGVVACSGVTRSRARSSAPRAPAAPAGPATVPSEGSGGSTPGWHTREEQPPSVAEGYASQDVFSATETSLWYDFLSDQASGLWGGDGPARQATQRLSVLLCANADGSEKLPPLVAGKSAKPRAGQGGLPCDYTANSKGGVTTQALAKYLKALDTRMAAESRRVLLLAGRLAAQSLDTSGLRHVQLAFFPPGTVHPLERGVVQQVKGHYRQAMLLKAMAALEGQDPSGLQLGLVEALHFVAAAWQAVEPSDIATCFREAGFGGGLNATITTSFKSEGEEEEEEEEEEEEEEEEEGEGEEEEEEEEEGEEEGGEGEEEGEEEVEEEGEVDDSDEEEEESSSEGLEAEDWAQGVVEASGGFGGYSVQEEAQFPTLHFLEGGEDSDSDSDEEEDDEEEDEEDEDEEDDEDGDEVPVPSFGEAMAYFAMVKRYLTSFPIDDRVQSHILHLEHDLVHVTRKNHARQAGVRGLGHQS
uniprot
proteins
function
FUNCTION: Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes. {ECO:0000250|UniProtKB:P07199}.
uniprot
proteins
mass_dalton
65381
uniprot
proteins
post_translational_modification
PTM: Poly-ADP-ribosylated by PARP1. {ECO:0000269|PubMed:12011073}.; PTM: N-terminally methylated by METTL11A/NTM1. Alpha-N-methylation is stimulated in response to extracellular stimuli, including increased cell density and heat shock, and seems to facilitate binding to CENP-B boxes. Chromatin-bound CENP-B is primarily trimethylated. {ECO:0000250|UniProtKB:P07199}.
uniprot
proteins
pubmed
12011073
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1893793
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
599
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P07199}. Chromosome, centromere {ECO:0000250|UniProtKB:P07199}.
uniprot
proteins