FYB1
entrez
2533
canonical
uniprot
O15117
canonical
ensembl
ENSG00000082074
resolver
ensp
ENSP00000316460
resolver
ensp
ENSP00000425845
resolver
ensp
ENSP00000493623
resolver
genesymbol
FYB1
resolver
genesymbol_syn
FYB
resolver
genesymbol_syn
SLAP130
resolver
hgnc
HGNC:4036
resolver
uniprot
A8K2Y8
resolver
uniprot
B4DLN2
resolver
uniprot
E9PBV9
resolver
uniprot
O00359
resolver
uniprot
Q9NZI9
resolver
uniprot_entry
FYB1_HUMAN
resolver
uniprot_sec
A8K2Y8
resolver
uniprot_sec
B4DLN2
resolver
uniprot_sec
E9PBV9
resolver
uniprot_sec
O00359
resolver
uniprot_sec
Q9NZI9
resolver
amino_acid_sequence
MAKYNTGGNPTEDVSVNSRPFRVTGPNSSSGIQARKNLFNNQGNASPPAGPSNVPKFGSPKPPVAVKPSSEEKPDKEPKPPFLKPTGAGQRFGTPASLTTRDPEAKVGFLKPVGPKPINLPKEDSKPTFPWPPGNKPSLHSVNQDHDLKPLGPKSGPTPPTSENEQKQAFPKLTGVKGKFMSASQDLEPKPLFPKPAFGQKPPLSTENSHEDESPMKNVSSSKGSPAPLGVRSKSGPLKPAREDSENKDHAGEISSLPFPGVVLKPAASRGGPGLSKNGEEKKEDRKIDAAKNTFQSKINQEELASGTPPARFPKAPSKLTVGGPWGQSQEKEKGDKNSATPKQKPLPPLFTLGPPPPKPNRPPNVDLTKFHKTSSGNSTSKGQTSYSTTSLPPPPPSHPASQPPLPASHPSQPPVPSLPPRNIKPPFDLKSPVNEDNQDGVTHSDGAGNLDEEQDSEGETYEDIEASKEREKKREKEEKKRLELEKKEQKEKEKKEQEIKKKFKLTGPIQVIHLAKACCDVKGGKNELSFKQGEQIEIIRITDNPEGKWLGRTARGSYGYIKTTAVEIDYDSLKLKKDSLGAPSRPIEDDQEVYDDVAEQDDISSHSQSGSGGIFPPPPDDDIYDGIEEEDADDGFPAPPKQLDMGDEVYDDVDTSDFPVSSAEMSQGTNVGKAKTEEKDLKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGESLEVIQTTDDTKVLCRNEEGKYGYVLRSYLADNDGEIYDDIADGCIYDND
uniprot
proteins
disease_involvement
DISEASE: Thrombocytopenia 3 (THC3) [MIM:273900]: A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. THC3 is an autosomal recessive form characterized by onset in infancy. {ECO:0000269|PubMed:25516138, ECO:0000269|PubMed:25876182}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}.
uniprot
proteins
mass_dalton
85387
uniprot
proteins
post_translational_modification
PTM: T-cell receptor ligation leads to increased tyrosine phosphorylation.
uniprot
proteins
pubmed
10747096
uniprot
proteins
pubmed
10856234
uniprot
proteins
pubmed
10942756
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15062083
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15849195
uniprot
proteins
pubmed
16461356
uniprot
proteins
pubmed
16980616
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19807924
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25516138
uniprot
proteins
pubmed
25876182
uniprot
proteins
pubmed
27335501
uniprot
proteins
pubmed
9115214
uniprot
proteins
pubmed
9207119
uniprot
proteins
pubmed
9671755
uniprot
proteins
pubmed
9748251
uniprot
proteins
pubmed
9755858
uniprot
proteins
sequence_length
783
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9671755}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}. Cell junction {ECO:0000250|UniProtKB:O35601}. Note=Colocalizes with TMEM47 at cell-cell contacts in podocytes. {ECO:0000250|UniProtKB:O35601}.
uniprot
proteins