Tmem108
entrez
81907
canonical
uniprot
Q8BHE4
canonical
ensembl
ENSMUSG00000042757
resolver
ensp
ENSMUSP00000046021
resolver
ensp
ENSMUSP00000140027
resolver
ensp
ENSMUSP00000141160
resolver
ensp
ENSMUSP00000316476
resolver
ensp
ENSMUSP00000316479
resolver
ensp
ENSMUSP00000316483
resolver
ensp
ENSMUSP00000316484
resolver
enst
ENSMUST00000049452
resolver
enst
ENSMUST00000189066
resolver
enst
ENSMUST00000189588
resolver
genesymbol
Tmem108
resolver
uniprot
Q80WR9
resolver
uniprot_entry
TM108_MOUSE
resolver
uniprot_sec
Q80WR9
resolver
amino_acid_sequence
MKRSLQALYCQLLSFLLTLALTKALVLAVHEPSPRESLQTLPSGSPPGTMVTAPHSPTRLSSVLTLNPTPDGPSSQAAATLETTVSHPEGHPPTDTTSTVMGTAAVPHPESPLPTGSPPAAMTTTPSHSESLPPGDATPTTTLPTKPAGTTSRPTVAPRATTRRPPRPPGSSRKGAGGSTRTLTPVPGGHLARKESQRGRNQSSAHLGPKRPLGKIFQIYKGNFTGSAEPDPSALTPRTPLGGYFSSTQPQTVSPATAPRSTSRVPPTTSLVPVKDKPGFIRSNQGSGPILTSPGGEPAATAATGAPASTQPAPVPSQSPHGDVQDSASHSDSWLAVTPDTDRPTSASSGVFTAATGPTQAAFDATVSAPSPGIPQGPSATPQAPTRPSGVSESTVSPAEEEAEASPTTTDRGPRPLSTVLSTATGNFLNRLVPAGTWKPGTVANISHVAEGDKPQHRATICLSKMDIAWVIVAISVPISSCSVLLTVCCMRRKKKTANPENNLSYWNNAITMDYFNRHAVELPREIQSLETSEDQLSEPRSPANGDYRDTGMVLVNPFCQETLFVGNDQVSEI
uniprot
proteins
function
FUNCTION: Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons (PubMed:28096412). Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport (PubMed:17287360). In hippocampal neurons, required for BDNF-dependent dendrite outgrowth (PubMed:21849472). Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes (PubMed:21849472, PubMed:27605705). {ECO:0000269|PubMed:17287360, ECO:0000269|PubMed:21849472, ECO:0000269|PubMed:27605705, ECO:0000269|PubMed:28096412}.
uniprot
proteins
mass_dalton
59642
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:17287360}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17287360
uniprot
proteins
pubmed
21849472
uniprot
proteins
pubmed
27605705
uniprot
proteins
pubmed
28096412
uniprot
proteins
sequence_length
574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:17287360}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic density {ECO:0000269|PubMed:28096412}. Endosome membrane {ECO:0000269|PubMed:17287360}. Cell projection, axon {ECO:0000269|PubMed:17287360, ECO:0000269|PubMed:21849472}. Cell projection, dendrite {ECO:0000269|PubMed:21849472}. Early endosome {ECO:0000269|PubMed:21849472}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 468..488; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins