Hgsnat
entrez
52120
canonical
uniprot
Q3UDW8
canonical
ensembl
ENSMUSG00000037260
resolver
ensp
ENSMUSP00000040356
resolver
genesymbol
Hgsnat
resolver
genesymbol_syn
D8Ertd354e
resolver
genesymbol_syn
Tmem76
resolver
uniprot
E9QNP9
resolver
uniprot
Q3TWK5
resolver
uniprot
Q8CBU7
resolver
uniprot
Q8CIE1
resolver
uniprot
Q9CX36
resolver
uniprot_entry
HGNAT_MOUSE
resolver
uniprot_entry
Q9CX36_MOUSE
resolver
uniprot_sec
E9QNP9
resolver
uniprot_sec
Q3TWK5
resolver
uniprot_sec
Q8CBU7
resolver
uniprot_sec
Q8CIE1
resolver
amino_acid_sequence
MTGGSSSRRRRAEERSSAAGTERNSRREAVGGMGAGPALAALLLAGSVLSATLLAPGRRAEPDLDEKRNVELKMDQALLLIHNELLGTSLTVYWKSDDCYQCTFQPLANVSHGGKPAKPSVAPVSVSTQHGSILQVNSTSEERAACRLEYKFGEFGNYSLLVQHASSGANKIACDIIVNENPVDSNLPVSIAFLVGLALIVAVSLLRLLLSLDDVNNWISKTIASRETDRLINSELGSPSRADPLSADYQPETRRSSANRLRCVDTFRGLALVLMVFVNYGGGKYWYFKHSSWNGLTVADLVFPWFVFIMGTSIFLSMTSILQRGCSKLKLLGKIVWRSFLLICIGVIIVNPNYCLGPLSWDKVRIPGVLQRLGVTYFVVAVLEFFFWKPVPDSCTLESSCFSLRDITSSWPQWLTILTLESIWLALTFFLPVPGCPTGYLGPGGIGDLGKYPHCTGGAAGYIDRLLLGDNHLYQHPSSTVLYHTEVAYDPEGVLGTINSIVMAFLGVQAGKILVYYKDQTKAILTRFAAWCCILGLISIVLTKVSANEGFIPINKNLWSISYVTTLSCFAFFILLILYPVVDVKGLWTGTPFFYPGMNSILVYVGHEVLENYFPFQWKLADEQSHKEHLIQNIVATALWVLIAYVLYKKKLFWKI
uniprot
proteins
ec_number
2.3.1.78
uniprot
proteins
function
FUNCTION: Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. {ECO:0000269|PubMed:16960811}.
uniprot
proteins
mass_dalton
72504
uniprot
proteins
post_translational_modification
PTM: Undergoes intralysosomal proteolytic cleavage; occurs within the end of the first and/or the beginning of the second luminal domain and is essential for the activation of the enzyme. {ECO:0000250}.; PTM: Glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16960811
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25859010
uniprot
proteins
sequence_length
656
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:16960811}; Multi-pass membrane protein {ECO:0000269|PubMed:16960811}. Note=Colocalizes with the lysosomal marker LAMP2. The signal peptide is not cleaved upon translocation into the endoplasmic reticulum; the precursor is probably targeted to the lysosomes via the adapter protein complex-mediated pathway that involves tyrosine- and/or dileucine-based conserved amino acid motifs in the last C-terminus 16-amino acid domain (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 186..206; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 296..316; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 339..359; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 368..388; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 414..434; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 494..514; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 523..543; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 558..578; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 586..606; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 628..648; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins