EIF4EBP3
entrez
8637
canonical
uniprot
O60516
canonical
ensembl
ENSG00000243056
resolver
ensp
ENSP00000308472
resolver
enst
ENST00000310331
resolver
genesymbol
EIF4EBP3
resolver
hgnc
HGNC:3290
resolver
uniprot_entry
4EBP3_HUMAN
resolver
amino_acid_sequence
MSTSTSCPIPGGRDQLPDCYSTTPGGTLYATTPGGTRIIYDRKFLLECKNSPIARTPPCCLPQIPGVTTPPTAPLSKLEELKEQETEEEIPDDAQFEMDI
uniprot
proteins
function
FUNCTION: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:22684010). {ECO:0000250|UniProtKB:Q13541, ECO:0000269|PubMed:22684010}.
uniprot
proteins
mass_dalton
10873
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="Y->A: Loss of interaction with EIF4E."; /evidence="ECO:0000269|PubMed:9593750"; MUTAGEN 45; /note="L->A: Loss of interaction with EIF4E."; /evidence="ECO:0000269|PubMed:9593750
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:9593750}.
uniprot
proteins
protein_family
EIF4E-binding protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22684010
uniprot
proteins
pubmed
9593750
uniprot
proteins
sequence_length
100
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22684010}. Nucleus {ECO:0000269|PubMed:22684010}.
uniprot
proteins