BBC3
entrez
27113
canonical
uniprot
Q96PG8
canonical
uniprot
Q9BXH1
canonical
ensembl
ENSG00000105327
resolver
ensp
ENSP00000300880
resolver
ensp
ENSP00000341155
resolver
ensp
ENSP00000395862
resolver
ensp
ENSP00000404503
resolver
ensp
ENSP00000569366
resolver
ensp
ENSP00000569367
resolver
genesymbol
BBC3
resolver
genesymbol_syn
PUMA
resolver
hgnc
HGNC:17868
resolver
uniprot
B9EGI3
resolver
uniprot
O00171
resolver
uniprot
Q96PG9
resolver
uniprot_entry
BBC3B_HUMAN
resolver
uniprot_entry
BBC3_HUMAN
resolver
uniprot_sec
B9EGI3
resolver
uniprot_sec
O00171
resolver
uniprot_sec
Q96PG9
resolver
amino_acid_sequence
MARARQEGSSPEPVEGLARDGPRPFPLGRLVPSAVSCGLCEPGLAAAPAAPTLLPAAYLCAPTAPPAVTAALGGSRWPGGPRSRPRGPRPDGPQPSLSLAEQHLESPVPSAPGALAGGPTQAAPGVRGEEEQWAREIGAQLRRMADDLNAQYERRRQEEQQRHRPSPWRVLYNLIMGLLPLPRGHRAPEMEPN
uniprot
proteins
amino_acid_sequence
MKFGMGSAQACPCQVPRAASTTWVPCQICGPRERHGPRTPGGQLPGARRGPGPRRPAPLPARPPGALGSVLRPLRARPGCRPRRPHPAARCLPLRPHRPTRRHRRPGGFPLAWGSPQPAPRPAPGRSSALALAGGAAPGVARAQRPGGSGGRSHPGGPGSPRGGGTVGPGDRGPAAADGGRPQRTVRAAETRGAAAAPPLTLEGPVQSHHGTPALTQGPQSPRDGAQLGACTRPVDVRDSGGRPLPPPDTLASAGDFLCTM
uniprot
proteins
function
FUNCTION: Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391, PubMed:23340338). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (PubMed:23340338). Regulates ER stress-induced neuronal apoptosis (By similarity). {ECO:0000250|UniProtKB:Q99ML1, ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:23340338}.
uniprot
proteins
function
FUNCTION: [Isoform 3]: Does not affect cell growth. {ECO:0000269|PubMed:11463392}.
uniprot
proteins
mass_dalton
20532
uniprot
proteins
mass_dalton
26498
uniprot
proteins
mutagenesis
MUTAGEN 133; /note="W->A: Impairs p53/TP53-dependent apoptosis."; /evidence="ECO:0000269|PubMed:23340338"; MUTAGEN 141..143; /note="Missing: Abolishes BLC2-binding. Impairs growth inhibitory activity. No effect on mitochondrial subcellular location."; /evidence="ECO:0000269|PubMed:11463392
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
11463391
uniprot
proteins
pubmed
11463392
uniprot
proteins
pubmed
11572983
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22761832
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23340338
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
193
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:11463392, ECO:0000269|PubMed:11572983}. Note=Localized to the mitochondria in order to induce cytochrome c release.
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Note=Contrary to isoforms 1 and 2, isoform 3 does not localize to the mitochondria.
uniprot
proteins