STAG3
entrez
10734
canonical
uniprot
Q9UJ98
canonical
ensembl
ENSG00000066923
resolver
ensp
ENSP00000319318
resolver
ensp
ENSP00000377586
resolver
ensp
ENSP00000400359
resolver
ensp
ENSP00000477973
resolver
ensp
ENSP00000608281
resolver
ensp
ENSP00000608282
resolver
ensp
ENSP00000608284
resolver
enst
ENST00000615138
resolver
enst
ENST00000938222
resolver
enst
ENST00000938225
resolver
genesymbol
STAG3
resolver
hgnc
HGNC:11356
resolver
uniprot
A6H8Z1
resolver
uniprot
B4DZ10
resolver
uniprot
D6W5U7
resolver
uniprot
D6W5U8
resolver
uniprot
H7BYK9
resolver
uniprot
Q8NDP3
resolver
uniprot_entry
D6W5U7_HUMAN
resolver
uniprot_entry
STAG3_HUMAN
resolver
uniprot_sec
A6H8Z1
resolver
uniprot_sec
B4DZ10
resolver
uniprot_sec
D6W5U8
resolver
uniprot_sec
H7BYK9
resolver
uniprot_sec
Q8NDP3
resolver
amino_acid_sequence
MSSPLQRAVGDTKRALSASSSSSASLPFDDRDSNHTSEGNGDSLLADEDTDFEDSLNRNVKKRAAKRPPKTTPVAKHPKKGSRVVHRHSRKQSEPPANDLFNAVKAAKSDMQSLVDEWLDSYKQDQDAGFLELVNFFIQSCGCKGIVTPEMFKKMSNSEIIQHLTEQFNEDSGDYPLIAPGPSWKKFQGSFCEFVRTLVCQCQYSLLYDGFPMDDLISLLTGLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSVHQDNNQRQYEAERNKGPGQRAPERLESLLEKRKELQEHQEEIEGMMNALFRGVFVHRYRDVLPEIRAICIEEIGCWMQSYSTSFLTDSYLKYIGWTLHDKHREVRLKCVKALKGLYGNRDLTTRLELFTSRFKDRMVSMVMDREYDVAVEAVRLLILILKNMEGVLTDADCESVYPVVYASHRGLASAAGEFLYWKLFYPECEIRMMGGREQRQSPGAQRTFFQLLLSFFVESELHDHAAYLVDSLWDCAGARLKDWEGLTSLLLEKDQNLGDVQESTLIEILVSSARQASEGHPPVGRVTGRKGLTSKERKTQADDRVKLTEHLIPLLPQLLAKFSADAEKVTPLLQLLSCFDLHIYCTGRLEKHLELFLQQLQEVVVKHAEPAVLEAGAHALYLLCNPEFTFFSRADFARSQLVDLLTDRFQQELEELLQSSFLDEDEVYNLAATLKRLSAFYNTHDLTRWELYEPCCQLLQKAVDTGEVPHQVILPALTLVYFSILWTLTHISKSDASQKQLSSLRDRMVAFCELCQSCLSDVDTEIQEQAFVLLSDLLLIFSPQMIVGGRDFLRPLVFFPEATLQSELASFLMDHVFIQPGDLGSGDSQEDHLQIERLHQRRRLLAGFCKLLLYGVLEMDAASDVFKHYNKFYNDYGDIIKETLTRARQIDRSHCSRILLLSLKQLYTELLQEHGPQGLNELPAFIEMRDLARRFALSFGPQQLQNRDLVVMLHKEGIQFSLSELPPAGSSNQPPNLAFLELLSEFSPRLFHQDKQLLLSYLEKCLQHVSQAPGHPWGPVTTYCHSLSPVENTAETSPQVLPSSKRRRVEGPAKPNREDVSSSQEESLQLNSIPPTPTLTSTAVKSRQPLWGLKEMEEEDGSELDFAQGQPVAGTERSRFLGPQYFQTPHNPSGPGLGNQLMRLSLMEEDEEEELEIQDESNEERQDTDMQASSYSSTSERGLDLLDSTELDIEDF
uniprot
proteins
disease_involvement
DISEASE: Premature ovarian failure 8 (POF8) [MIM:615723]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. {ECO:0000269|PubMed:24597867, ECO:0000269|PubMed:30006057, ECO:0000269|PubMed:32634216, ECO:0000269|PubMed:34707299, ECO:0000303|PubMed:22428046}. Note=The disease is caused by variants affecting the gene represented in this entry. A homozygous deletion in STAG3 predicted to result in frameshift and premature truncation, has been shown to be the cause of premature ovarian failure in a large consanguineous family. {ECO:0000269|PubMed:24597867}.; DISEASE: Spermatogenic failure 61 (SPGF61) [MIM:619672]: An autosomal recessive male infertility disorder characterized by non-obstructive azoospermia, due to complete meiotic arrest at the primary spermatocyte stage. {ECO:0000269|PubMed:31682730, ECO:0000269|PubMed:32634216, ECO:0000269|PubMed:32741963}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. {ECO:0000269|PubMed:31682730}.
uniprot
proteins
mass_dalton
139034
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
SCC3 family
uniprot
proteins
pubmed
10698974
uniprot
proteins
pubmed
12034751
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
22428046
uniprot
proteins
pubmed
24597867
uniprot
proteins
pubmed
30006057
uniprot
proteins
pubmed
31682730
uniprot
proteins
pubmed
32634216
uniprot
proteins
pubmed
32741963
uniprot
proteins
pubmed
34707299
uniprot
proteins
sequence_length
1225
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00750, ECO:0000269|PubMed:12034751}. Chromosome {ECO:0000269|PubMed:12034751}. Chromosome, centromere {ECO:0000269|PubMed:12034751}. Note=Associates with chromatin. In prophase I stage of meiosis, it is found along the axial elements of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. It however remains chromatin associated at the centromeres up to metaphase I. During anaphase I, it probably dissociates from centromeres, allowing chromosomes segregation. {ECO:0000269|PubMed:12034751}.
uniprot
proteins