PSIP1
entrez
11168
canonical
uniprot
O75475
canonical
ensembl
ENSG00000164985
resolver
ensp
ENSP00000370091
resolver
ensp
ENSP00000370092
resolver
ensp
ENSP00000370109
resolver
ensp
ENSP00000370114
resolver
ensp
ENSP00000380653
resolver
ensp
ENSP00000651743
resolver
ensp
ENSP00000651744
resolver
ensp
ENSP00000651745
resolver
ensp
ENSP00000684410
resolver
genesymbol
PSIP1
resolver
genesymbol_syn
DFS70
resolver
genesymbol_syn
LEDGF
resolver
genesymbol_syn
PSIP2
resolver
hgnc
HGNC:9527
resolver
uniprot
D3DRI9
resolver
uniprot
O00256
resolver
uniprot
O95368
resolver
uniprot
Q6P391
resolver
uniprot
Q86YB9
resolver
uniprot
Q9NZI3
resolver
uniprot
Q9UER6
resolver
uniprot_entry
PSIP1_HUMAN
resolver
uniprot_sec
D3DRI9
resolver
uniprot_sec
O00256
resolver
uniprot_sec
O95368
resolver
uniprot_sec
Q6P391
resolver
uniprot_sec
Q86YB9
resolver
uniprot_sec
Q9NZI3
resolver
uniprot_sec
Q9UER6
resolver
amino_acid_sequence
MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1 exon 4. {ECO:0000269|PubMed:15725483}.
uniprot
proteins
function
FUNCTION: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}.
uniprot
proteins
mass_dalton
60103
uniprot
proteins
mutagenesis
MUTAGEN 360; /note="K->A: Reduced interaction with POGZ, CDCA7L and human HIV-1 integrase."; /evidence="ECO:0000269|PubMed:19244240"; MUTAGEN 365; /note="I->A: Loss of interaction with human HIV-1 integrase; reduced interaction with POGZ and CDCA7L."; /evidence="ECO:0000269|PubMed:15895093, ECO:0000269|PubMed:19244240"; MUTAGEN 366; /note="D->A: Loss of interaction with human HIV-1 integrase; no effect on interaction with CDCA7L and POGZ."; /evidence="ECO:0000269|PubMed:19244240"; MUTAGEN 366; /note="D->N: Loss of interaction with human HIV-1 integrase; no effect on interaction with KMT2A."; /evidence="ECO:0000269|PubMed:15895093, ECO:0000269|PubMed:25082813"; MUTAGEN 368; /note="L->A: Reduced interaction with KMT2A. Significant loss of interaction with KMT2A; when associated with D-407."; /evidence="ECO:0000269|PubMed:25082813"; MUTAGEN 370; /note="V->A: Reduced interaction with POGZ, CDCA7L and human HIV-1 integrase."; /evidence="ECO:0000269|PubMed:19244240"; MUTAGEN 404; /note="R->D: Significant loss of interaction with KMT2A; when associated with D-405."; /evidence="ECO:0000269|PubMed:25082813"; MUTAGEN 405; /note="R->D: Significant loss of interaction with KMT2A; when associated with D-404."; /evidence="ECO:0000269|PubMed:25082813"; MUTAGEN 406; /note="F->A: Loss of interaction with human HIV-1 integrase and POGZ; reduced interaction with CDCA7L."; /evidence="ECO:0000269|PubMed:15895093, ECO:0000269|PubMed:19244240"; MUTAGEN 407; /note="K->D: Reduced interaction with KMT2A. Significant loss of interaction with KMT2A; when associated with A-368."; /evidence="ECO:0000269|PubMed:25082813"; MUTAGEN 408; /note="V->A: Reduced interaction with human HIV-1 integrase; no effect on interaction with POGZ and CDCA7L."; /evidence="ECO:0000269|PubMed:15895093, ECO:0000269|PubMed:19244240
uniprot
proteins
post_translational_modification
PTM: Citrullinated by PADI4. {ECO:0000250|UniProtKB:Q99JF8}.
uniprot
proteins
protein_family
HDGF family
uniprot
proteins
pubmed
10623627
uniprot
proteins
pubmed
10721720
uniprot
proteins
pubmed
10856157
uniprot
proteins
pubmed
12200376
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15475359
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15642333
uniprot
proteins
pubmed
15725483
uniprot
proteins
pubmed
15749713
uniprot
proteins
pubmed
15797927
uniprot
proteins
pubmed
15895093
uniprot
proteins
pubmed
16260736
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19244240
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22327296
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25082813
uniprot
proteins
pubmed
25305204
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29997176
uniprot
proteins
pubmed
9822615
uniprot
proteins
pubmed
9885563
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15642333, ECO:0000269|PubMed:9885563}. Note=Remains chromatin-associated throughout the cell cycle.
uniprot
proteins