Hus1
entrez
15574
canonical
uniprot
Q8BQY8
canonical
ensembl
ENSMUSG00000020413
resolver
ensp
ENSMUSP00000020683
resolver
ensp
ENSMUSP00000226802
resolver
genesymbol
Hus1
resolver
uniprot
O70543
resolver
uniprot
Q6P8H5
resolver
uniprot_entry
HUS1_MOUSE
resolver
uniprot_sec
O70543
resolver
uniprot_sec
Q6P8H5
resolver
amino_acid_sequence
MKFRAKIVDLACLNHFTRVSNMIAKLAKTCTLRISPEKLNFILCDKLASGGVSMWCELEQENFFSEFQMEGVSEENNEIYLELTSENLSRALKTAQNSRALKIKLTNKHFPCLTVSVELVSSSSSSRIVVHDIPIKVLPRRLWKDLQEPSIPDCDVSICLPALKMMKSVVEKMRNISNQLVIEANLKGELNLKIETELVCVTTHFKDLENPLLPSDSVSQNRHPEDMAKVHIDIKKLLQFLAGQQVTPTKAVCNIVNNRTVHFDLLLEDVSLQYFIPALS
uniprot
proteins
function
FUNCTION: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. {ECO:0000250|UniProtKB:O60921}.
uniprot
proteins
mass_dalton
31680
uniprot
proteins
protein_family
HUS1 family
uniprot
proteins
pubmed
10395797
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9878245
uniprot
proteins
sequence_length
280
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O60921}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O60921}. Note=In discrete nuclear foci upon DNA damage. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm. {ECO:0000250|UniProtKB:O60921}.
uniprot
proteins