Adat3
entrez
100125374
canonical
uniprot
Q561R2
canonical
ensembl
ENSRNOG00000063591
resolver
ensp
ENSRNOP00000089590
resolver
ensp
ENSRNOP00000103572
resolver
enst
ENSRNOT00000095368
resolver
enst
ENSRNOT00000125787
resolver
genesymbol
Adat3
resolver
uniprot_entry
ADAT3_RAT
resolver
amino_acid_sequence
MEPTSGFAEQPGPEKVESEEQEPAQWQALPVLSEQQSGAVELVLAYAAPVLDKRQTSRLLREVSAVYPLPAQPHLKRVRPSRSAGGAHSSDLLLCLAGPSAGPRSLAELLPRPAVDPRGLGTPFLVPVPARPPLTRSQFEEARAHWPTSFHEDKQVTSALAGQLFSAQARAAMQTHMERAVRAAQRAAAQGLRAVGAVVVDPASDHVLATGHDCCSEASPLLHAVMVCIDLVAQGQGRGSCDLRRHPACSFTQATATQSARAGSVRKLDEDSLPYVCTGYDLYVTREPCVMCAMALVHARIQRVFYGAPSPDGALGTRFRVHARPDLNHRFQVFRGILEDQCRQLDPDP
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of the tRNA-specific adenosine-34 deaminase complex, composed of the ADAT2 catalytic subunit and the ADAT3 regulatory subunit, which deaminates adenosine-34 (the first, also called wobble position of the anticodon) to inosine in many tRNAs. Inosine-34 allows the decoding of 3 different nucleotides at the third position of mRNA codons, as inosine is able to pair with U, C, and A. Required for binding of the ADAT2-ADAT3 complex to tRNA through its N-terminus, which rotates with respect to the catalytic domain of the complex, formed by ADAT2 and the ADAT3 C-terminal domain, to position the tRNA anticodon stem-loop correctly in the ADAT2 active site. The ADAT2-ADAT3 complex is required for radial migration of projection neurons in the developing brain cortex, and the catalytic activity of the complex is necessary for this function. {ECO:0000250|UniProtKB:Q6PAT0}.
uniprot
proteins
mass_dalton
37704
uniprot
proteins
protein_family
ADAT3 subfamily
uniprot
proteins
protein_family
Cytidine and deoxycytidylate deaminase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6PAT0}. Cytoplasm {ECO:0000250|UniProtKB:Q6PAT0}. Note=The ADAT2-ADAT3 complex shows a diffuse expression pattern in both the cytoplasm and the nucleus. {ECO:0000250|UniProtKB:Q6PAT0}.
uniprot
proteins