Kcnh3
entrez
16512
canonical
uniprot
Q9WVJ0
canonical
ensembl
ENSMUSG00000037579
resolver
ensp
ENSMUSP00000040548
resolver
ensp
ENSMUSP00000282969
resolver
enst
ENSMUST00000041415
resolver
genesymbol
Kcnh3
resolver
genesymbol_syn
Elk2
resolver
uniprot
B2RU85
resolver
uniprot
E9QMZ8
resolver
uniprot
Q6U1M1
resolver
uniprot_entry
KCNH3_MOUSE
resolver
uniprot_sec
B2RU85
resolver
uniprot_sec
E9QMZ8
resolver
uniprot_sec
Q6U1M1
resolver
amino_acid_sequence
MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVALFLVSHKDISETKNRGGPDNWKERGGGRRRYGRAGSKGFNANRRRSRAVLYHLSGHLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHAFKVNVYVGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQQEIESSESELPEIGWLQELARRLETPYYLVSRSPDGGNSSGQSENCSSSSSSSGSGGGRGSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPQREQVVKANADVKGLTYCVLQCLQLAGLHESLALYPEFAPRFSRGLRGELSYNLGAGGVSAEVDTSSLSGDNTLMSTLEEKETDGEQGHTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPSRAGVLKPEAGPSAHPRSLDGLQLPPMPWNVPPDLSPRVVDGIEDGCSSDQPKFSFRVGQSGPECSSSPSPGTESGLLTVPLGPSEARNTDTLDKLRQAVMELSEQVLQMREGLQSLRQAVQLILVPQGEGQCPRGSGEEPCPATASGLLQPLRVDTGASSYCLQPPAGSVLSGTWPHPRPGQPPPLMAPWPWGPPASQSSPWPRATALWTSTSDSEPPGSGDLCSEPSTPASPPPSEEGARTGTPAPVSQAEATSTGEPPPGPGGRALPWDPHSLEMVLIGCHGPGTVQWTQEEGTGV
uniprot
proteins
function
FUNCTION: Pore-forming (alpha) subunit of a voltage-gated inwardly rectifying potassium channel (PubMed:10191308, PubMed:19623261, PubMed:19808681). Charactherized by a fast rate of activation during depolarization followed by a rapid inactivation at much more depolarized value causing inward rectification due to a C-type inactivation mechanism (PubMed:10191308, PubMed:19623261). Exhibits a rapid recovery from inactivation (PubMed:10191308). {ECO:0000269|PubMed:10191308, ECO:0000269|PubMed:19623261, ECO:0000269|PubMed:19808681}.
uniprot
proteins
mass_dalton
118244
uniprot
proteins
mutagenesis
MUTAGEN 421; /note="N->Q: Impairs trafficking to the cell membrane; when associated with Q-428 and Q-447. Impairs N-glycosylation; when associated with Q-428 and Q-447."; /evidence="ECO:0000269|PubMed:19808681"; MUTAGEN 428; /note="N->Q: Impairs trafficking to the cell membrane; when associated with Q-421 and Q-447. Impairs N-glycosylation; when associated with Q-421 and Q-447."; /evidence="ECO:0000269|PubMed:19808681"; MUTAGEN 447; /note="N->Q: Impairs trafficking to the cell membrane; when associated with Q-421 and Q-428. Impairs N-glycosylation; when associated with Q-421 and Q-428."; /evidence="ECO:0000269|PubMed:19808681
uniprot
proteins
post_translational_modification
PTM: N-glycosylated (PubMed:19808681). N-glycosylation mediates traffick to the cell membrane but is not necessary for voltage-gated potassium channel activity (PubMed:19808681). {ECO:0000269|PubMed:19808681}.
uniprot
proteins
protein_family
H (Eag) (TC 1.A.1.20) subfamily
uniprot
proteins
protein_family
Kv12.2/KCNH3 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10191308
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19623261
uniprot
proteins
pubmed
19808681
uniprot
proteins
sequence_length
1095
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19623261}; Multi-pass membrane protein. Note=Expression on the cell membrane requires at least one of the three glycosylation sites to carry a sugar chain irrespective of their positions. {ECO:0000269|PubMed:19808681}.
uniprot
proteins
transmembrane_region
TRANSMEM 229..249; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 303..323; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 332..352; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 491..511; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins