Fth1
entrez
25319
canonical
uniprot
P19132
canonical
ensembl
ENSRNOG00000076813
resolver
ensp
ENSRNOP00000111565
resolver
genesymbol
Fth1
resolver
genesymbol_syn
Fth
resolver
uniprot
F7F0Q6
resolver
uniprot_entry
F7F0Q6_RAT
resolver
uniprot_entry
FRIH_RAT
resolver
amino_acid_sequence
MTTASPSQVRQNYHQDSEAAINRQINLELYASYVYLSMSCYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDRDDWESGLNAMRCALHLEKSVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKSIKELGDHVTNLRKMGAPESGMAEYLFDKHTLGHGDES
uniprot
proteins
ec_number
1.16.3.1
uniprot
proteins
function
FUNCTION: Stores iron in a soluble, non-toxic, readily available form (By similarity). Important for iron homeostasis (By similarity). Has ferroxidase activity (By similarity). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (By similarity). {ECO:0000250|UniProtKB:P02794, ECO:0000250|UniProtKB:P09528}.
uniprot
proteins
mass_dalton
21127
uniprot
proteins
protein_family
Ferritin family
uniprot
proteins
pubmed
2827671
uniprot
proteins
pubmed
3478702
uniprot
proteins
pubmed
6546756
uniprot
proteins
sequence_length
182
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P19130}. Lysosome {ECO:0000250|UniProtKB:P02794}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:P02794}.
uniprot
proteins