COPS2
entrez
9318
canonical
uniprot
P61201
canonical
ensembl
ENSG00000166200
resolver
ensp
ENSP00000299259
resolver
ensp
ENSP00000373553
resolver
genesymbol
COPS2
resolver
genesymbol_syn
CSN2
resolver
genesymbol_syn
TRIP15
resolver
hgnc
HGNC:30747
resolver
uniprot
O88950
resolver
uniprot
Q15647
resolver
uniprot
Q59EL2
resolver
uniprot
Q6FGP4
resolver
uniprot
Q9BY54
resolver
uniprot
Q9R249
resolver
uniprot
Q9UNI2
resolver
uniprot
Q9UNQ5
resolver
uniprot_entry
CSN2_HUMAN
resolver
uniprot_entry
Q59EL2_HUMAN
resolver
uniprot_sec
O88950
resolver
uniprot_sec
Q15647
resolver
uniprot_sec
Q6FGP4
resolver
uniprot_sec
Q9BY54
resolver
uniprot_sec
Q9R249
resolver
uniprot_sec
Q9UNI2
resolver
uniprot_sec
Q9UNQ5
resolver
amino_acid_sequence
MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYISTSKQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA
uniprot
proteins
function
FUNCTION: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
uniprot
proteins
mass_dalton
51597
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CK2 and PKD kinases. {ECO:0000269|PubMed:12628923}.
uniprot
proteins
protein_family
CSN2 family
uniprot
proteins
pubmed
10207062
uniprot
proteins
pubmed
10713076
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
10991940
uniprot
proteins
pubmed
11285227
uniprot
proteins
pubmed
11337588
uniprot
proteins
pubmed
12628923
uniprot
proteins
pubmed
12732143
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18850735
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26456823
uniprot
proteins
pubmed
7776974
uniprot
proteins
pubmed
9535219
uniprot
proteins
sequence_length
443
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:10207062}.
uniprot
proteins