Dcp2
entrez
70640
canonical
uniprot
Q9CYC6
canonical
ensembl
ENSMUSG00000024472
resolver
ensp
ENSMUSP00000025350
resolver
enst
ENSMUST00000025350
resolver
genesymbol
Dcp2
resolver
uniprot
Q3TLD9
resolver
uniprot
Q3U671
resolver
uniprot_entry
DCP2_MOUSE
resolver
uniprot_entry
Q3U671_MOUSE
resolver
uniprot_sec
Q3TLD9
resolver
amino_acid_sequence
MEPKRLEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPGLPQCGIRDFAKAVFSHCPFLLPQGEDVEKILDEWKEYKMGVPTYGAIILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGVPKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSDNGFSSAGSTPARPTVEKLSRTKFRHSQQLFPEGSPSDQWVKHRQPLQQKSHSNHGEVSDLLKAKNQNMRGNGRKQYQDSPNQKKRANGVHGQPAKQQNPLVKCEKKLHPRKLQDNFETDATCDLPCSGEEPSVEHAEGHSVACNGHCKFPFSSRAFLSFKFDQNAIMKILDL
uniprot
proteins
ec_number
3.6.1.62
uniprot
proteins
function
FUNCTION: Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:21070968). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:21070968). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (By similarity). Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (By similarity). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (By similarity). {ECO:0000250|UniProtKB:Q8IU60, ECO:0000269|PubMed:21070968}.
uniprot
proteins
mass_dalton
48380
uniprot
proteins
protein_family
DCP2 subfamily
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21070968
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000250|UniProtKB:Q8IU60}. Nucleus {ECO:0000250|UniProtKB:Q8IU60}. Note=Predominantly cytoplasmic, in processing bodies (PB) (By similarity). A minor amount is nuclear (By similarity). {ECO:0000250|UniProtKB:Q8IU60}.
uniprot
proteins