Mfsd2a
entrez
76574
canonical
uniprot
Q9DA75
canonical
ensembl
ENSMUSG00000028655
resolver
ensp
ENSMUSP00000030408
resolver
enst
ENSMUST00000030408
resolver
genesymbol
Mfsd2a
resolver
genesymbol_syn
Mfsd2
resolver
genesymbol_syn
Nls1
resolver
uniprot
Q80ZW8
resolver
uniprot_entry
NLS1_MOUSE
resolver
uniprot_sec
Q80ZW8
resolver
amino_acid_sequence
MAKGEGAESGSAAGLLPTSILQASERPVQVKKEPKKKQQLSICNKLCYAVGGAPYQLTGCALGFFLQIYLLDVAKVEPLPASIILFVGRAWDAFTDPLVGFCISKSSWTRLGRLMPWIIFSTPLAIIAYFLIWFVPDFPSGTESSHGFLWYLLFYCLFETLVTCFHVPYSALTMFISTEQSERDSATAYRMTVEVLGTVIGTAIQGQIVGQAKAPCLQDQNGSVVVSEVANRTQSTASLKDTQNAYLLAAGIIASIYVLCAFILILGVREQRELYESQQAESMPFFQGLRLVMGHGPYVKLIAGFLFTSLAFMLVEGNFALFCTYTLDFRNEFQNLLLAIMLSATFTIPIWQWFLTRFGKKTAVYIGISSAVPFLILVALMERNLIVTYVVAVAAGVSVAAAFLLPWSMLPDVIDDFHLKHPHSPGTEPIFFSFYVFFTKFASGVSLGVSTLSLDFANYQRQGCSQPEQVKFTLKMLVTMAPIILILLGLLLFKLYPIDEEKRRQNKKALQALREEASSSGCSDTDSTELASIL
uniprot
proteins
function
FUNCTION: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (PubMed:18694395, PubMed:23209793, PubMed:24828040, PubMed:24828044, PubMed:34349262). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (PubMed:24828040, PubMed:24828044, PubMed:34349262). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (PubMed:24828040, PubMed:24828044, PubMed:34349262). Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (PubMed:24828044, PubMed:34349262). Does not transport docosahexaenoic acid in unesterified fatty acid (PubMed:24828044). Not required for central nervous system vascular morphogenesis (PubMed:24828040). {ECO:0000269|PubMed:18694395, ECO:0000269|PubMed:23209793, ECO:0000269|PubMed:24828040, ECO:0000269|PubMed:24828044, ECO:0000269|PubMed:34349262}.
uniprot
proteins
mass_dalton
58984
uniprot
proteins
mutagenesis
MUTAGEN 55; /note="Y->A: Significant reduction in LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 56; /note="Q->A: Slightly reduced LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 64; /note="F->A: Slightly increased LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 67; /note="Q->H: Abolishes LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 82; /note="S->A: No effect on LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 86; /note="F->A: Slightly reduced LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 89; /note="R->A: No effect on LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 92; /note="D->A: Significant reduction in LPC transport. Abolishes LPC transport; when associated with A-96."; /evidence="ECO:0000269|PubMed:24828044, ECO:0000269|PubMed:34349262"; MUTAGEN 95; /note="T->A: Significant reduction in LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 96; /note="D->A: Abolishes LPC transport. Abolishes LPC transport; when associated with A-92."; /evidence="ECO:0000269|PubMed:24828044, ECO:0000269|PubMed:34349262"; MUTAGEN 159; /note="E->A: Slightly reduced LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 163; /note="T->A: Slightly reduced LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 163; /note="T->M: Abolishes LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 166; /note="H->A: Abolishes LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 168; /note="P->T: Significant reduction in LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 170; /note="S->L: Significant reduction in LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 190; /note="R->A: Abolishes LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 194; /note="E->A: Significant reduction in LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 202; /note="T->A: Slightly increased LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 202; /note="T->F: Significant reduction in LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 202; /note="T->M: Significant reduction in LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 207; /note="Q->A: Slightly reduced LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 216; /note="C->A: Significant reduction in LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 254; /note="A->F: Abolishes LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 305; /note="F->A: Significant reduction in LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 309; /note="S->A: Significant reduction in LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 330; /note="R->H: No effect on LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 334; /note="Q->A: Slightly reduced LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 335; /note="N->A: Significant reduction in LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 343; /note="S->L: Significant reduction in LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 403; /note="F->A: Significant reduction in LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 406; /note="P->H: Significant reduction in LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 407; /note="W->A: Significant reduction in LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 439; /note="T->A: No effect on LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 440; /note="K->A: Abolishes LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 451; /note="T->A: Slightly reduced LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 455; /note="D->A: Slightly reduced LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 461; /note="R->A: Slightly reduced LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 464; /note="C->A: Significant reduction in LPC transport."; /evidence="ECO:0000269|PubMed:34349262"; MUTAGEN 497; /note="P->L: Abolishes LPC transport."; /evidence="ECO:0000269|PubMed:34349262
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:23209793}.
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18694395
uniprot
proteins
pubmed
23209793
uniprot
proteins
pubmed
24828040
uniprot
proteins
pubmed
24828044
uniprot
proteins
pubmed
26005868
uniprot
proteins
pubmed
34349262
uniprot
proteins
sequence_length
534
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23209793, ECO:0000269|PubMed:24828040}; Multi-pass membrane protein {ECO:0000269|PubMed:34349262}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18694395}; Multi-pass membrane protein {ECO:0000269|PubMed:34349262}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..69; /note="Helical"; /evidence="ECO:0000269|PubMed:34349262, ECO:0007744|PDB:7N98"; TRANSMEM 81..101; /note="Helical"; /evidence="ECO:0000269|PubMed:34349262, ECO:0007744|PDB:7N98"; TRANSMEM 114..133; /note="Helical"; /evidence="ECO:0000269|PubMed:34349262, ECO:0007744|PDB:7N98"; TRANSMEM 149..173; /note="Helical"; /evidence="ECO:0000269|PubMed:34349262, ECO:0007744|PDB:7N98"; TRANSMEM 181..212; /note="Helical"; /evidence="ECO:0000269|PubMed:34349262, ECO:0007744|PDB:7N98"; TRANSMEM 233..266; /note="Helical"; /evidence="ECO:0000269|PubMed:34349262, ECO:0007744|PDB:7N98"; TRANSMEM 298..324; /note="Helical"; /evidence="ECO:0000269|PubMed:34349262, ECO:0007744|PDB:7N98"; TRANSMEM 336..354; /note="Helical"; /evidence="ECO:0000269|PubMed:34349262, ECO:0007744|PDB:7N98"; TRANSMEM 359..380; /note="Helical"; /evidence="ECO:0000269|PubMed:34349262, ECO:0007744|PDB:7N98"; TRANSMEM 384..420; /note="Helical"; /evidence="ECO:0000269|PubMed:34349262, ECO:0007744|PDB:7N98"; TRANSMEM 431..457; /note="Helical"; /evidence="ECO:0000269|PubMed:34349262, ECO:0007744|PDB:7N98"; TRANSMEM 470..493; /note="Helical"; /evidence="ECO:0000269|PubMed:34349262, ECO:0007744|PDB:7N98
uniprot
proteins