Slc30a1
entrez
22782
canonical
uniprot
Q60738
canonical
ensembl
ENSMUSG00000037434
resolver
ensp
ENSMUSP00000042410
resolver
enst
ENSMUST00000044954
resolver
genesymbol
Slc30a1
resolver
genesymbol_syn
Znt1
resolver
uniprot
Q3UM63
resolver
uniprot_entry
Q3UM63_MOUSE
resolver
uniprot_entry
ZNT1_MOUSE
resolver
amino_acid_sequence
MGCWGRNRGRLLCMLLLTFMFMVLEVVVSRVTASLAMLSDSFHMLSDVLALVVALVAERFARRTHATQKNTFGWIRAEVMGALVNAIFLTGLCFAILLEAVERFIEPHEMQQPLVVLSVGVAGLLVNVLGLCLFHHHSGEGQGAGHGHSHGHGHGHLAKGARKAGRAGVEAGAPPGRAPDQEETNTLVANTSNSNGLKADQAEPEKLRSDDPVDVQVNGNLIQESDNLEAEDNRAGQLNMRGVFLHVLGDALGSVIVVVNALVFYFNWKGCTEDDFCTNPCFPDPCKSSVEIINSTQAPMRDAGPCWVLYLDPTLCIIMVCILLYTTYPLLKESALILLQTVPKQIDIKHLVKELRDVDGVEEVHELHVWQLAGSRIIATAHIKCEDPASYMQVAKTIKDVFHNHGIHATTIQPEFASVGSKSSVLPCELACRTQCALKQCCGTRPQVHSGKDAEKAPTVSISCLELSENLEKKARRTKAEGSLPAVVIEIKNVPNKQPESSL
uniprot
proteins
function
FUNCTION: Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:39422023, PubMed:39111308). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (PubMed:15451416). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (By similarity). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (By similarity). Down-regulates the activity of transcription factors induced by zinc and cytokines (By similarity). Also functions as a copper transporter, facilitating the entry of copper into cells, which is crucial for copper-induced cell death (cuproptosis) (PubMed:39111308). Acts as a Zn(2+)/Ca(2+) exchanger, exporting zinc in exchange for calcium influx (PubMed:34871934). {ECO:0000250|UniProtKB:Q9Y6M5, ECO:0000269|PubMed:15451416, ECO:0000269|PubMed:34871934, ECO:0000305|PubMed:15452870}.
uniprot
proteins
mass_dalton
54716
uniprot
proteins
protein_family
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
uniprot
proteins
protein_family
SLC30A subfamily
uniprot
proteins
pubmed
15451416
uniprot
proteins
pubmed
15452870
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17101726
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24602382
uniprot
proteins
pubmed
34871934
uniprot
proteins
pubmed
39111308
uniprot
proteins
pubmed
39422023
uniprot
proteins
pubmed
7882967
uniprot
proteins
sequence_length
503
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17101726, ECO:0000269|PubMed:24602382}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:17101726, ECO:0000269|PubMed:39422023}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9Y6M5}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:17101726}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y6M5}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Y6M5}; Multi-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:Q9Y6M5}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic density {ECO:0000269|PubMed:24602382}. Note=Localization to the plasma membrane is regulated by cellular zinc status. Recruitment to the plasma membrane from an internal pool is stimulated by zinc while in absence of zinc the plasma membrane pool is endocytosed and degraded (By similarity). Localizes to the basolateral surface of enterocytes (By similarity). Localizes to zinc-containing intracellular vesicles in macrophages (By similarity). Localizes in the cytoplasm and to the ER, Golgi and nucleus membranes in keratinocytes (By similarity). {ECO:0000250|UniProtKB:Q62720, ECO:0000250|UniProtKB:Q9Y6M5}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 244..264; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 304..324; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins