Creb3l4
entrez
310616
canonical
uniprot
Q5UEM7
canonical
ensembl
ENSRNOG00000023493
resolver
ensembl
ENSRNOG00055021903
resolver
ensembl
ENSRNOG00060029948
resolver
ensembl
ENSRNOG00065028772
resolver
ensp
ENSRNOP00000033353
resolver
genesymbol
Creb3l4
resolver
genesymbol_syn
Aibzip
resolver
uniprot
Q5UEM6
resolver
uniprot_entry
CR3L4_RAT
resolver
uniprot_sec
Q5UEM6
resolver
amino_acid_sequence
MELGCPELLEPPEDIFSTGSFLELGFNGPPSKVPGLQKSESDDFLNLFIDPNMIRCSETSPGSDSGVSEDPGSPAPQAPSSPALYEVVYEAGALQGTQREAGPTFGLISIQIDQWSPAFMVPGACTVSDLPSEAHRHILPRVSTIAPPPPAALLSCQRLFLTDEEKHLLGQEGVTLPSHLPLTKAEERILKKIRRKIRNKQSAQDSRRRKKEYIDGLESRVAACSEQNQKLQRKVQELERQNISLVAQVHQLQKFTAQTSSRAAQTSTCVLILLFSLALIILPSFSPFQSQPEARSEGYQLHGVISRNILTHEDMTESPESPVLKANLEELPQVPATNGSTKMAHLKMRVKARPTGPIRGMVHADEM
uniprot
proteins
function
FUNCTION: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. Increases the binding of CREM isoform Delta with CRE. The CREM isoform Delta-CREB3L4 heterodimer functions through CRE but not through UPRE and may recruit HIRA to CRE to regulate histone exchange (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
40281
uniprot
proteins
post_translational_modification
PTM: Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
ATF subfamily
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 4]: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 268..288; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins