P49356
uniprot
P49356
canonical
amino_acid_sequence
MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFEELKDETSAEPATD
uniprot
proteins
ec_number
2.5.1.58
uniprot
proteins
function
FUNCTION: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8494894}.
uniprot
proteins
mass_dalton
48774
uniprot
proteins
mutagenesis
MUTAGEN 102; /note="W->T: Removes the steric hindrance that normally precludes geranylgeranyl diphosphate binding. Reduces farnesyltransferase activity and confers geranylgeranyltransferase activity."; /evidence="ECO:0000269|PubMed:16893176"; MUTAGEN 200; /note="D->N: Reduced catalytic efficiency."; /evidence="ECO:0000269|PubMed:8494894"; MUTAGEN 249; /note="G->V: Reduced catalytic efficiency."; /evidence="ECO:0000269|PubMed:8494894"; MUTAGEN 349; /note="G->S: Reduced catalytic efficiency."; /evidence="ECO:0000269|PubMed:8494894
uniprot
proteins
protein_family
Protein prenyltransferase subunit beta family
uniprot
proteins
pubmed
11687658
uniprot
proteins
pubmed
12036349
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12825937
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15451670
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16893176
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
19246009
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
8276393
uniprot
proteins
pubmed
8494894
uniprot
proteins
sequence_length
437
uniprot
proteins