Cd8b
entrez
24931
canonical
uniprot
P05541
canonical
ensembl
ENSRNOG00000007129
resolver
ensp
ENSRNOP00000009392
resolver
enst
ENSRNOT00000009392
resolver
genesymbol
Cd8b
resolver
genesymbol_syn
Cd8b1
resolver
uniprot
A0ACM8Q351
resolver
uniprot
G3V6V7
resolver
uniprot
Q6PCV0
resolver
uniprot_entry
A0ACM8Q351_RAT
resolver
uniprot_entry
CD8B_RAT
resolver
uniprot_entry
G3V6V7_RAT
resolver
uniprot_sec
Q6PCV0
resolver
amino_acid_sequence
MQPWLWLVFSVKLSALWGSSALLQTPSSLLVQTNQTAKMSCEAKTFPKGTTIYWLRELQDSNKNKHFEFLASRTSTKGIKYGERVKKNMTLSFNSTLPFLKIMDVKPEDSGFYFCAMVGSPMVVFGTGTKLTVVDVLPTTAPTKKTTLKKKQCPTPHPKTQKGLTCGLITLSLLVACILVLLVSLSVAIHFHCMRRRARIHFMKQFHK
uniprot
proteins
function
FUNCTION: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells. {ECO:0000250|UniProtKB:P10300, ECO:0000250|UniProtKB:P10966}.
uniprot
proteins
mass_dalton
23400
uniprot
proteins
post_translational_modification
PTM: Phosphorylated as a consequence of T-cell activation. {ECO:0000250|UniProtKB:P10966}.; PTM: Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers. {ECO:0000250|UniProtKB:P10966}.
uniprot
proteins
pubmed
3092111
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P10966}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P10966}. Note=Requires the partner CD8A for efficient cell surface expression. The heterodimer CD8A/CD8B localizes to lipid rafts due to CD8B cytoplasmic tail palmitoylation. {ECO:0000250|UniProtKB:P10966}.
uniprot
proteins
transmembrane_region
TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins