TSEN34
entrez
79042
canonical
uniprot
Q9BSV6
canonical
ensembl
ENSG00000170892
resolver
ensembl
ENSG00000273896
resolver
ensembl
ENSG00000274078
resolver
ensembl
ENSG00000274129
resolver
ensembl
ENSG00000274672
resolver
ensembl
ENSG00000274796
resolver
ensembl
ENSG00000275165
resolver
ensembl
ENSG00000278605
resolver
ensembl
ENSG00000278622
resolver
ensembl
ENSG00000278712
resolver
ensp
ENSP00000305524
resolver
ensp
ENSP00000379667
resolver
ensp
ENSP00000379671
resolver
ensp
ENSP00000397402
resolver
ensp
ENSP00000400743
resolver
ensp
ENSP00000477766
resolver
ensp
ENSP00000478156
resolver
ensp
ENSP00000478203
resolver
ensp
ENSP00000478451
resolver
ensp
ENSP00000478622
resolver
ensp
ENSP00000479105
resolver
ensp
ENSP00000479563
resolver
ensp
ENSP00000479576
resolver
ensp
ENSP00000479654
resolver
ensp
ENSP00000480422
resolver
ensp
ENSP00000480503
resolver
ensp
ENSP00000480899
resolver
ensp
ENSP00000480964
resolver
ensp
ENSP00000481068
resolver
ensp
ENSP00000481374
resolver
ensp
ENSP00000481639
resolver
ensp
ENSP00000482084
resolver
ensp
ENSP00000482527
resolver
ensp
ENSP00000482737
resolver
ensp
ENSP00000483157
resolver
ensp
ENSP00000483220
resolver
ensp
ENSP00000483266
resolver
ensp
ENSP00000483436
resolver
ensp
ENSP00000484225
resolver
ensp
ENSP00000484239
resolver
ensp
ENSP00000484465
resolver
ensp
ENSP00000484555
resolver
ensp
ENSP00000484694
resolver
ensp
ENSP00000484865
resolver
ensp
ENSP00000484964
resolver
ensp
ENSP00000499595
resolver
ensp
ENSP00000532823
resolver
ensp
ENSP00000532824
resolver
ensp
ENSP00000532825
resolver
ensp
ENSP00000532826
resolver
ensp
ENSP00000532827
resolver
ensp
ENSP00000532828
resolver
ensp
ENSP00000637054
resolver
enst
ENST00000302937
resolver
enst
ENST00000396383
resolver
enst
ENST00000396388
resolver
enst
ENST00000429671
resolver
enst
ENST00000455798
resolver
enst
ENST00000611560
resolver
enst
ENST00000611798
resolver
enst
ENST00000612236
resolver
enst
ENST00000612393
resolver
enst
ENST00000613310
resolver
enst
ENST00000613337
resolver
enst
ENST00000613653
resolver
enst
ENST00000613712
resolver
enst
ENST00000613888
resolver
enst
ENST00000614483
resolver
enst
ENST00000614734
resolver
enst
ENST00000614948
resolver
enst
ENST00000614984
resolver
enst
ENST00000615000
resolver
enst
ENST00000615079
resolver
enst
ENST00000615811
resolver
enst
ENST00000615900
resolver
enst
ENST00000615975
resolver
enst
ENST00000616063
resolver
enst
ENST00000616209
resolver
enst
ENST00000617149
resolver
enst
ENST00000617543
resolver
enst
ENST00000617902
resolver
enst
ENST00000618135
resolver
enst
ENST00000618447
resolver
enst
ENST00000619263
resolver
enst
ENST00000619273
resolver
enst
ENST00000619994
resolver
enst
ENST00000622524
resolver
enst
ENST00000622538
resolver
enst
ENST00000667261
resolver
enst
ENST00000862764
resolver
enst
ENST00000862765
resolver
enst
ENST00000862766
resolver
enst
ENST00000862767
resolver
enst
ENST00000862768
resolver
enst
ENST00000862769
resolver
enst
ENST00000966995
resolver
genesymbol
TSEN34
resolver
genesymbol_syn
LENG5
resolver
genesymbol_syn
SEN34
resolver
hgnc
HGNC:15506
resolver
uniprot
A0A590UJW4
resolver
uniprot
A6NNB1
resolver
uniprot
B0V3J1
resolver
uniprot
B4DT51
resolver
uniprot
E7EQB3
resolver
uniprot
Q9BVT1
resolver
uniprot
Q9H6H5
resolver
uniprot_entry
A0A590UJW4_HUMAN
resolver
uniprot_entry
B4DT51_HUMAN
resolver
uniprot_entry
E7EQB3_HUMAN
resolver
uniprot_entry
SEN34_HUMAN
resolver
uniprot_sec
A6NNB1
resolver
uniprot_sec
B0V3J1
resolver
uniprot_sec
Q9BVT1
resolver
uniprot_sec
Q9H6H5
resolver
amino_acid_sequence
MLVVEVANGRSLVWGAEAVQALRERLGVGGRTVGALPRGPRQNSRLGLPLLLMPEEARLLAEIGAVTLVSAPRPDSRHHSLALTSFKRQQEESFQEQSALAAEARETRRQELLEKITEGQAAKKQKLEQASGASSSQEAGSSQAAKEDETSDGQASGEQEEAGPSSSQAGPSNGVAPLPRSALLVQLATARPRPVKARPLDWRVQSKDWPHAGRPAHELRYSIYRDLWERGFFLSAAGKFGGDFLVYPGDPLRFHAHYIAQCWAPEDTIPLQDLVAAGRLGTSVRKTLLLCSPQPDGKVVYTSLQWASLQ
uniprot
proteins
disease_involvement
DISEASE: Pontocerebellar hypoplasia 2C (PCH2C) [MIM:612390]: A disorder characterized by an abnormally small cerebellum and brainstem, and progressive microcephaly from birth combined with extrapyramidal dyskinesia. Severe chorea occurs and epilepsy is frequent. There are no signs of spinal cord anterior horn cells degeneration. {ECO:0000269|PubMed:18711368}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
4.6.1.16
uniprot
proteins
function
FUNCTION: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}.
uniprot
proteins
mass_dalton
33652
uniprot
proteins
protein_family
TRNA-intron endonuclease family
uniprot
proteins
pubmed
10941842
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15109492
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18711368
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15109492}. Nucleus, nucleolus {ECO:0000269|PubMed:15109492}. Note=May be transiently localized in the nucleolus.
uniprot
proteins