ARHGAP10
entrez
79658
canonical
uniprot
A1A4S6
canonical
ensembl
ENSG00000071205
resolver
ensp
ENSP00000336923
resolver
ensp
ENSP00000630032
resolver
enst
ENST00000336498
resolver
genesymbol
ARHGAP10
resolver
genesymbol_syn
GRAF2
resolver
hgnc
HGNC:26099
resolver
uniprot
A1L0S5
resolver
uniprot
Q2VPC4
resolver
uniprot
Q2VPC5
resolver
uniprot
Q96EV3
resolver
uniprot
Q96S75
resolver
uniprot_entry
RHG10_HUMAN
resolver
uniprot_sec
A1L0S5
resolver
uniprot_sec
Q2VPC4
resolver
uniprot_sec
Q2VPC5
resolver
uniprot_sec
Q96EV3
resolver
uniprot_sec
Q96S75
resolver
amino_acid_sequence
MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKFAHSLRDFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKFNMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPPDTTFPEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTPTSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATVADKPPESIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL
uniprot
proteins
function
FUNCTION: GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11432776). Also converts Cdc42 to an inactive GDP-bound state (PubMed:11432776). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (PubMed:32344433). {ECO:0000250|UniProtKB:Q6Y5D8, ECO:0000269|PubMed:11432776, ECO:0000269|PubMed:32344433}.
uniprot
proteins
mass_dalton
89375
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylated in vitro by constitutive active PKN3. {ECO:0000269|PubMed:11432776}.
uniprot
proteins
pubmed
11432776
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
32344433
uniprot
proteins
sequence_length
786
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}. Endosome membrane {ECO:0000269|PubMed:32344433}. Note=Association to cell membrane is dependent on PH domain. Colocalized with MICAL1, RAB8A, RAB8B and RAB10 on endosomal tubules (PubMed:32344433). {ECO:0000250, ECO:0000269|PubMed:32344433}.
uniprot
proteins