Socs7
entrez
192157
canonical
uniprot
Q8VHQ2
canonical
ensembl
ENSMUSG00000038485
resolver
ensp
ENSMUSP00000040896
resolver
ensp
ENSMUSP00000158611
resolver
ensp
ENSMUSP00000205898
resolver
ensp
ENSMUSP00000205899
resolver
enst
ENSMUST00000045540
resolver
enst
ENSMUST00000238729
resolver
genesymbol
Socs7
resolver
genesymbol_syn
Cish7
resolver
genesymbol_syn
Nap4
resolver
uniprot
A0A571BEJ5
resolver
uniprot
B1AQY1
resolver
uniprot
Q3UH08
resolver
uniprot_entry
A0A571BEJ5_MOUSE
resolver
uniprot_entry
SOCS7_MOUSE
resolver
uniprot_sec
B1AQY1
resolver
uniprot_sec
Q3UH08
resolver
amino_acid_sequence
MVFRNVGRPPEEEDAEAAREPGPSELLCPRHRCALDPKALPPGLALERTWGPVAGLEAQLAALGLGQPAGPGIKTAGGGCCPCPCPPQPPPPQPPPPAAAPQAGEDPTETSDALLVLEGLESEAESLETNSCSEEELSSPGRGGGGVGGRLLLQPPGPELPPVPFPLQDLVPPGRLSRGEQQQQQPPPPPPPPGPLRPLAGPSRKGSFKIRLSRLFRTKSCNGGSGGGDGTGKRPSGDLAASAASLTDMGGSAVRELDTGRKPRLTRTQSAFSPVSFSPLFTGETVSLVDVDISQRGLTSPHPPTPPPPPRRSLSLLDDISGTLPTSVLVAPMGSSLQSFPLPPPPPPHAPDAFPRIAPIRASESLHSQPPQHLQCPLYRPDSSSFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIPDLPLPKPLISYIRKFYYYDPQEEVYLSLKEAQLISKQKQEVEPST
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1 (PubMed:16127460, PubMed:24210661). Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination (PubMed:24210661). The ECS(SOCS7) complex acts as a key regulator of reelin signaling by mediating ubiquitination and degradation of phosphorylated DAB1 in the cortical plate of the developing cerebral cortex, thereby regulating neuron positioning during cortex development (PubMed:24210661). Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation (PubMed:16127460). Also inhibits prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA (By similarity). {ECO:0000250|UniProtKB:O14512, ECO:0000269|PubMed:16127460, ECO:0000269|PubMed:24210661}.
uniprot
proteins
mass_dalton
62784
uniprot
proteins
mutagenesis
MUTAGEN 519..520; /note="LC->QQ: Abolished formation of the ECS(SOCS7) complex."; /evidence="ECO:0000269|PubMed:24210661
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:24210661}.
uniprot
proteins
pubmed
12052866
uniprot
proteins
pubmed
15242778
uniprot
proteins
pubmed
15494444
uniprot
proteins
pubmed
16127460
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24210661
uniprot
proteins
sequence_length
579
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15242778}. Nucleus {ECO:0000269|PubMed:15242778}. Cell membrane {ECO:0000269|PubMed:15242778}; Peripheral membrane protein {ECO:0000269|PubMed:15242778}; Cytoplasmic side {ECO:0000269|PubMed:15242778}. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence. {ECO:0000250|UniProtKB:O14512}.
uniprot
proteins