Khdrbs3
entrez
13992
canonical
uniprot
Q9R226
canonical
ensembl
ENSMUSG00000022332
resolver
ensp
ENSMUSP00000022954
resolver
ensp
ENSMUSP00000154887
resolver
ensp
ENSMUSP00000155136
resolver
ensp
ENSMUSP00000270009
resolver
enst
ENSMUST00000022954
resolver
enst
ENSMUST00000229234
resolver
enst
ENSMUST00000229683
resolver
genesymbol
Khdrbs3
resolver
genesymbol_syn
Salp
resolver
genesymbol_syn
Slm2
resolver
uniprot
O88624
resolver
uniprot_entry
KHDR3_MOUSE
resolver
uniprot_sec
O88624
resolver
amino_acid_sequence
MEEKYLPELMAEKDSLDPSFTHALRLVNREIEKFQKGEGKEEEKYIDVVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDLHVLIEVFAPPAEAYARMGHALEEIKKFLIPDYNDEIRQAQLQELTYLNGGSENADVPVVRGKSTLRTRGVTTPAITRGRGGVTARPVAVGVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPPPPPTQETYGEYDYDDGYGTAYDEQSYDSYDNSYSTPAQSAADYYDYGHGLSEDAYDSYGQEEWTNSRHKAPSARTAKGVYRDQPYGRY
uniprot
proteins
function
FUNCTION: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro (PubMed:19457263). Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides (By similarity). Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:15471878). Involved in splice site selection of vascular endothelial growth factor (By similarity). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members. High concentrations in forebrain structures block splicing inclusion of NRXN1-3 AS4 exons while low concentrations favor their inclusion. Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity and is linked to behavioral aspects (PubMed:22196734, PubMed:23637638, PubMed:24469635, PubMed:27174676). Regulates expression of KHDRBS2/SLIM-1 in defined neuron populations in the hippocampus by modifying its alternative splicing resulting in a transcript predicted to undergo nonsense-mediated decay (PubMed:25505328). Can bind FABP9 mRNA (PubMed:19916944). May play a role as a negative regulator of cell growth. Inhibits cell proliferation. {ECO:0000250|UniProtKB:O75525, ECO:0000250|UniProtKB:Q9JLP1, ECO:0000269|PubMed:15471878, ECO:0000269|PubMed:19457263, ECO:0000269|PubMed:19916944, ECO:0000269|PubMed:22196734, ECO:0000269|PubMed:23637638, ECO:0000269|PubMed:24469635, ECO:0000269|PubMed:27174676}.
uniprot
proteins
mass_dalton
38807
uniprot
proteins
mutagenesis
MUTAGEN 129; /note="V->F: Abolishes splicing regulation."; /evidence="ECO:0000269|PubMed:23637638"; MUTAGEN 215..217; /note="AVG->GVV: Confers SIAH1-mediated degradation and strong SIAH1 binding."; /evidence="ECO:0000269|PubMed:15163637
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by PTK6. {ECO:0000269|PubMed:15471878}.
uniprot
proteins
protein_family
KHDRBS family
uniprot
proteins
pubmed
10077576
uniprot
proteins
pubmed
10332027
uniprot
proteins
pubmed
15163637
uniprot
proteins
pubmed
15471878
uniprot
proteins
pubmed
19457263
uniprot
proteins
pubmed
19916944
uniprot
proteins
pubmed
22196734
uniprot
proteins
pubmed
23637638
uniprot
proteins
pubmed
24469635
uniprot
proteins
pubmed
25505328
uniprot
proteins
pubmed
27174676
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10332027, ECO:0000269|PubMed:15471878}. Note=Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.
uniprot
proteins