Atp2c1
entrez
235574
canonical
uniprot
Q80XR2
canonical
ensembl
ENSMUSG00000032570
resolver
ensp
ENSMUSP00000039103
resolver
ensp
ENSMUSP00000082220
resolver
ensp
ENSMUSP00000108177
resolver
ensp
ENSMUSP00000129617
resolver
ensp
ENSMUSP00000135802
resolver
ensp
ENSMUSP00000243945
resolver
ensp
ENSMUSP00000243946
resolver
ensp
ENSMUSP00000243970
resolver
enst
ENSMUST00000038118
resolver
enst
ENSMUST00000085133
resolver
enst
ENSMUST00000112558
resolver
enst
ENSMUST00000163879
resolver
genesymbol
Atp2c1
resolver
genesymbol_syn
Pmr1
resolver
genesymbol_syn
mKIAA1347
resolver
uniprot
E9QMB9
resolver
uniprot
F6ZD75
resolver
uniprot
F7AHS2
resolver
uniprot
Q3UZR5
resolver
uniprot
Q69ZL4
resolver
uniprot
Q80YZ2
resolver
uniprot
Q8BMS7
resolver
uniprot_entry
AT2C1_MOUSE
resolver
uniprot_entry
F6ZD75_MOUSE
resolver
uniprot_entry
F7AHS2_MOUSE
resolver
uniprot_entry
Q3UZR5_MOUSE
resolver
uniprot_entry
Q69ZL4_MOUSE
resolver
uniprot_entry
Q8BMS7_MOUSE
resolver
uniprot_sec
E9QMB9
resolver
uniprot_sec
Q80YZ2
resolver
amino_acid_sequence
MKVARFQKIPNVENETMIPVLTSKRASELAVSEVAGLLQADLQNGLNKSEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISILMRQFDDAVSITVAIVIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSVDESSLTGETAPCSKVTAPQPAANGDLASRSNIAFMGTLVRCGKAKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHILTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYNSKGQTLALTQQQRDLYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAIAIASRLGLYSKTSQSVSGEEVDTMEVQHLSQIVPKVAVFYRASPRHKMKIIKSLQKNGAVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNKMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVSEIIKKVERSREKVQKNAGSASSSFLEV
uniprot
proteins
ec_number
7.2.2.10
uniprot
proteins
function
FUNCTION: ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (By similarity). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (By similarity). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology. Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (By similarity). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (PubMed:19793975). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (By similarity). {ECO:0000250|UniProtKB:P98194, ECO:0000269|PubMed:19793975}.
uniprot
proteins
mass_dalton
100299
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIA subfamily
uniprot
proteins
pubmed
14747290
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17597066
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19793975
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
918
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P98194}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:19793975}; Multi-pass membrane protein {ECO:0000255}. Note=During neuron differentiation, shifts from juxtanuclear Golgi position to multiple Golgi structures distributed over the neural soma with a predominance in the apical dendritic trunk. {ECO:0000269|PubMed:19793975}.
uniprot
proteins
transmembrane_region
TRANSMEM 79..95; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..121; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 263..282; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 295..316; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 700..722; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 728..751; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 776..794; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 802..827; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 843..862; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 876..892; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins