Rtn2
entrez
308410
canonical
uniprot
Q6WN19
canonical
ensembl
ENSRNOG00000016603
resolver
ensembl
ENSRNOG00055032929
resolver
ensembl
ENSRNOG00060032928
resolver
ensembl
ENSRNOG00065031307
resolver
ensp
ENSRNOP00000092461
resolver
ensp
ENSRNOP00055047059
resolver
ensp
ENSRNOP00060047177
resolver
ensp
ENSRNOP00065044458
resolver
enst
ENSRNOT00055056963
resolver
enst
ENSRNOT00060057097
resolver
enst
ENSRNOT00065054028
resolver
genesymbol
Rtn2
resolver
genesymbol_syn
Nspl1
resolver
uniprot
F1LM00
resolver
uniprot_entry
RTN2_RAT
resolver
uniprot_sec
F1LM00
resolver
amino_acid_sequence
MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEDEEEETTSQDWGTPRELTFSYIAFDGVVGSGGRRDSVVRRPRPQGRSVSEPRDPPPQPSLGDSLESIPSLSQSPEPGRRGDPDTVPPAERPLEELRLRLDQLGWAVRSAGSGEDSATSSSTPLENEEPDGLEASEAGETNLELRLAQPLHLQFEGLTPQLSPSSGIPQAHTPSPQRSQDLNTGPDEPLPNGEGEHWRLLEQEPITAQCLNSTDQSEFTLEPLLLVADLLYWKDTRTSGAIFTGLMASLLCLLHFSIVSVAAHLALLGLCATISLRVYRKVLQAVHRGDGTNPFQAYLDMDLTLTREQTERLSQQIASHVVSTATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLVILGVVALFTVPLLYRQHQAQIDQYVGLVTSQLSHIKAKIRAKIPGTGTLAPAASVSGSKAKAE
uniprot
proteins
function
FUNCTION: Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity (By similarity). Enhances trafficking of the glutamate transporter SLC1A1/EAAC1 from the endoplasmic reticulum to the cell surface (PubMed:18096700). Plays a role in the translocation of SLC2A4/GLUT4 from intracellular membranes to the cell membrane which facilitates the uptake of glucose into the cell (By similarity). {ECO:0000250|UniProtKB:O70622, ECO:0000250|UniProtKB:O75298, ECO:0000269|PubMed:18096700}.
uniprot
proteins
mass_dalton
50967
uniprot
proteins
pubmed
12832288
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18096700
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|RuleBase:RU210713, ECO:0000269|PubMed:18096700}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU210713}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:O70622}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:18096700}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:O70622}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O70622}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:O70622}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O70622}. Note=Localizes to intermediate filaments in mononucleated myoblasts and to Z lines in mature myotubes. {ECO:0000250|UniProtKB:O70622}.
uniprot
proteins
transmembrane_region
TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 388..408; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins