Dok2
entrez
13449
canonical
uniprot
O70469
canonical
ensembl
ENSMUSG00000022102
resolver
ensp
ENSMUSP00000022698
resolver
enst
ENSMUST00000022698
resolver
genesymbol
Dok2
resolver
genesymbol_syn
Frip
resolver
uniprot
O70272
resolver
uniprot
Q3TX09
resolver
uniprot
Q99KL1
resolver
uniprot_entry
DOK2_MOUSE
resolver
uniprot_entry
Q3TX09_MOUSE
resolver
uniprot_sec
O70272
resolver
uniprot_sec
Q99KL1
resolver
amino_acid_sequence
MVRMEEPAVKQGFLHLQQQQTFGKKWRRFAAVLYGESGCALARLELQDVPEKTRRGEATRKVVRLSDCLRVAEVGSEASSPRDTSAFILETKERLYLLAAPSAERSDWIQAICLLAFPGQRKGSPGLEEKSGSPCMEENELYSSSTTGLCKEYMVTIRPTEASERCRLRGSYTLRTGVSALELWGGPEPGTQLYDWPYRFLRRFGRDKATFSFEAGRRCLSGEGNFEFETRHGNEIFQALEKVIAVQKNATPSGPPSLPATGPMMPTVLPRPESPYSRPHDSLPSPSPGTLVPGMRPGAPEGEYAVPFDTVAHSLRKSFRGLLTGPPPHLPDPLYDSIQEDPGAPLPDHIYDEPEGVAALSLYDRTQRPSGETWREQATADGGPSSLQQDSSVPDWPQATEYDNVILKKGPK
uniprot
proteins
function
FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation.
uniprot
proteins
mass_dalton
45522
uniprot
proteins
mutagenesis
MUTAGEN 276; /note="Y->F: No loss of binding to SH2 domain of RASGAP or NCK. Complete loss of binding to SH2 domain of RASGAP; when associated with F-304."; /evidence="ECO:0000269|PubMed:10508618"; MUTAGEN 304; /note="Y->F: No loss of binding to SH2 domain of RASGAP. Complete loss of binding to SH2 domain of RASGAP; when associated with F-276."; /evidence="ECO:0000269|PubMed:10508618"; MUTAGEN 351; /note="Y->F: No loss of binding to SH2 domain of RASGAP. Complete loss of binding to SH2 domain of NCK."; /evidence="ECO:0000269|PubMed:10508618
uniprot
proteins
post_translational_modification
PTM: On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-351 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-276 and Tyr-304 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2. {ECO:0000269|PubMed:10508618, ECO:0000269|PubMed:11470823, ECO:0000269|PubMed:12665569, ECO:0000269|PubMed:9697832}.
uniprot
proteins
protein_family
DOK family
uniprot
proteins
protein_family
Type A subfamily
uniprot
proteins
pubmed
10508618
uniprot
proteins
pubmed
11470823
uniprot
proteins
pubmed
12665569
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9478921
uniprot
proteins
pubmed
9697832
uniprot
proteins
pubmed
9764820
uniprot
proteins
sequence_length
412
uniprot
proteins