Tpm2
entrez
22004
canonical
uniprot
P58774
canonical
ensembl
ENSMUSG00000028464
resolver
ensp
ENSMUSP00000030184
resolver
ensp
ENSMUSP00000103546
resolver
ensp
ENSMUSP00000103547
resolver
ensp
ENSMUSP00000267724
resolver
enst
ENSMUST00000030184
resolver
genesymbol
Tpm2
resolver
genesymbol_syn
Tpm-2
resolver
uniprot
A2AIM4
resolver
uniprot
P02560
resolver
uniprot
P46901
resolver
uniprot
Q61344
resolver
uniprot
Q6PJ18
resolver
uniprot
Q9D1R6
resolver
uniprot_entry
A2AIM4_MOUSE
resolver
uniprot_entry
Q61344_MOUSE
resolver
uniprot_entry
Q6PJ18_MOUSE
resolver
uniprot_entry
Q9D1R6_MOUSE
resolver
uniprot_entry
TPM2_MOUSE
resolver
uniprot_sec
P02560
resolver
uniprot_sec
P46901
resolver
amino_acid_sequence
MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKDAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL
uniprot
proteins
function
FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (PubMed:16094730). {ECO:0000250|UniProtKB:P58775, ECO:0000269|PubMed:16094730}.
uniprot
proteins
mass_dalton
32837
uniprot
proteins
mutagenesis
MUTAGEN 61; /note="S->A: Abolishes ADRB2 internalization."; /evidence="ECO:0000269|PubMed:16094730
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization. {ECO:0000269|PubMed:16094730}.
uniprot
proteins
protein_family
Tropomyosin family
uniprot
proteins
pubmed
16094730
uniprot
proteins
pubmed
1733968
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2461223
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P58775}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P58775}.
uniprot
proteins