Stac2
entrez
217154
canonical
uniprot
Q8R1B0
canonical
ensembl
ENSMUSG00000017400
resolver
ensp
ENSMUSP00000017544
resolver
enst
ENSMUST00000017544
resolver
genesymbol
Stac2
resolver
uniprot
Q8BV93
resolver
uniprot
Q8K2U4
resolver
uniprot_entry
STAC2_MOUSE
resolver
uniprot_sec
Q8BV93
resolver
uniprot_sec
Q8K2U4
resolver
amino_acid_sequence
MTEMSEKENEPDDAATHTPPGTVSTLQETKLQRFKRSLSLKTILRSKSVENFFLRSGSELKCPTEVLLTPPTPLPPPSPPPASTDRGLPTPTPSPCPVPRPLAPLKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKTCKVSVHLWCSEEISHQQCPGKTSTSFRRNFSSPLLVHAPPPACAMNKESPPTGTSGKVDPVYETLRYGTSLALMNRSSFSSTSESPTRSLSERDELTEDGEGSIRSSEEGPGDSVFTAPAESEGSGPEEKSPGQQPPKLPLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFSGNKEQGYMSLKENQICVGVSRSKDSDGFIRVSSGKKRGLVPADSLAEI
uniprot
proteins
function
FUNCTION: Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity (PubMed:29467163). Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:25548159, PubMed:29363593). Negative regulator of osteoclastogenesis. Following TNFSF11/RANKL stimulation, interacts with TNFRSF11A/RANK and interferes with the formation of the TNFRSF11A signaling complex, leading to the suppression of TNFSF11-initiated NF-kappa-B and MAPK signaling pathways. Impairs TNFSF11-induced, BTK/TEC-catalyzed PLCG2 phosphorylation and activation (PubMed:29348675). {ECO:0000269|PubMed:25548159, ECO:0000269|PubMed:29348675, ECO:0000269|PubMed:29363593, ECO:0000269|PubMed:29467163}.
uniprot
proteins
mass_dalton
44793
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23818578
uniprot
proteins
pubmed
25548159
uniprot
proteins
pubmed
28112192
uniprot
proteins
pubmed
29348675
uniprot
proteins
pubmed
29363593
uniprot
proteins
pubmed
29467163
uniprot
proteins
sequence_length
408
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:28112192, ECO:0000269|PubMed:29467163}. Cell membrane {ECO:0000269|PubMed:25548159}; Peripheral membrane protein {ECO:0000305|PubMed:25548159}; Cytoplasmic side {ECO:0000305|PubMed:25548159}. Cell membrane, sarcolemma {ECO:0000269|PubMed:29467163}; Peripheral membrane protein {ECO:0000269|PubMed:29467163}; Cytoplasmic side {ECO:0000269|PubMed:29467163}. Membrane raft {ECO:0000269|PubMed:29348675}. Note=Colocalizes with CACNA1C at the plasma membrane of transfected cells. Following TNFSF11/RANKL stimulation, recruited to lipid rafts along with TNFRSF11A/RANK (PubMed:29348675). {ECO:0000269|PubMed:25548159, ECO:0000269|PubMed:29348675}.
uniprot
proteins