Aph1a
entrez
226548
canonical
uniprot
Q8BVF7
canonical
ensembl
ENSMUSG00000015750
resolver
ensp
ENSMUSP00000015894
resolver
ensp
ENSMUSP00000058846
resolver
genesymbol
Aph1a
resolver
uniprot
Q6GTF1
resolver
uniprot
Q8R1T3
resolver
uniprot
Q91VL5
resolver
uniprot_entry
APH1A_MOUSE
resolver
uniprot_entry
Q6GTF1_MOUSE
resolver
uniprot_sec
Q8R1T3
resolver
uniprot_sec
Q91VL5
resolver
amino_acid_sequence
MGAAVFFGCTFVAFGPAFSLFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLSCRRQEDSRVMVYSALRIPPED
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:15634781, PubMed:19369254). Required for normal gamma-secretase assembly (PubMed:15634781, PubMed:19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). {ECO:0000269|PubMed:15634781, ECO:0000269|PubMed:19369254, ECO:0000305}.
uniprot
proteins
mass_dalton
28986
uniprot
proteins
protein_family
APH-1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15634781
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19369254
uniprot
proteins
sequence_length
265
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96BI3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96BI3}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q96BI3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96BI3}. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi. {ECO:0000250|UniProtKB:Q96BI3}.
uniprot
proteins
transmembrane_region
TRANSMEM 3..23; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q96BI3"; TRANSMEM 32..52; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q96BI3"; TRANSMEM 69..89; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q96BI3"; TRANSMEM 119..139; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q96BI3"; TRANSMEM 159..179; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q96BI3"; TRANSMEM 187..207; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q96BI3"; TRANSMEM 214..234; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q96BI3
uniprot
proteins