Adgrb2
entrez
230775
canonical
uniprot
Q8CGM1
canonical
ensembl
ENSMUSG00000028782
resolver
ensp
ENSMUSP00000101636
resolver
ensp
ENSMUSP00000101638
resolver
ensp
ENSMUSP00000112524
resolver
ensp
ENSMUSP00000112869
resolver
ensp
ENSMUSP00000309356
resolver
ensp
ENSMUSP00000309357
resolver
ensp
ENSMUSP00000309358
resolver
ensp
ENSMUSP00000309359
resolver
ensp
ENSMUSP00000309361
resolver
ensp
ENSMUSP00000309362
resolver
ensp
ENSMUSP00000309366
resolver
ensp
ENSMUSP00000309370
resolver
ensp
ENSMUSP00000309382
resolver
ensp
ENSMUSP00000309384
resolver
enst
ENSMUST00000120204
resolver
genesymbol
Adgrb2
resolver
genesymbol_syn
Bai2
resolver
uniprot
B1ASB7
resolver
uniprot
B1ASB8
resolver
uniprot
B1ASC0
resolver
uniprot
B2FDE3
resolver
uniprot
Q3TYC8
resolver
uniprot
Q3UN11
resolver
uniprot
Q3UNE2
resolver
uniprot
Q6PGN0
resolver
uniprot_entry
AGRB2_MOUSE
resolver
uniprot_entry
B1ASC0_MOUSE
resolver
uniprot_sec
B1ASB7
resolver
uniprot_sec
B1ASB8
resolver
uniprot_sec
B2FDE3
resolver
uniprot_sec
Q3TYC8
resolver
uniprot_sec
Q3UN11
resolver
uniprot_sec
Q3UNE2
resolver
uniprot_sec
Q6PGN0
resolver
activity_regulation
ACTIVITY REGULATION: Receptor activity is regulated by proteolytic processing. The long N-terminal has a an inhibitory effect on the constitutive signaling activity. Removal of the N-terminal region induces an increase of the receptor activity. {ECO:0000250|UniProtKB:O60241}.
uniprot
proteins
amino_acid_sequence
MTPACPLLLSVILSLRLATAFDPAPSACSALASGVLYGAFSLQDLFPTIASGCSWTLENPDPTKYSLYLRFNRQEQVCTHFAPRLLPLDHYLVNFTCLRPGPEEATARAESEVGRPEEEEEEAAAAASGLELCGGSGPFTFLHFDKNFVQLCLSAEPSEAPRLLAPAALAFRFVEVLLINNNNSSQFTCGVLCRWSEECGRAAGRACGFAQPGCSCPGEAGANPATTTSPGPPVAHTLSNALVPGGPAPPAEADLHSGSSNDLFTTEMRYGEEPEEEPKVKTQWPRSADEPGLYMAQTGDPAAEEWSPWSVCSLTCGQGLQVRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTKLCSMAACPVEGQWLEWGPWGPCSSSCANGTQQRSRKCSVAGPAWATCAGALTDTRECSNLDCPATDGKWGPWNAWSLCSKTCDTGWQRRFRMCQASGTQGYPCEGTGEEVKPCSEKRCPAFHEMCRDEYVMLMTWKRAAAGEIIYNKCPPNASGSASRRCLLSAQGVAYWGLPSFARCISHEYRYLYLSLREHLAKGQRMLAGEGMSQVVRSLQELLARRTYYSGDLLFSVDILRNVTDTFKRATYVPSADDVQRFFQVVSFMVDSENKDKWDDAQQVSPGSVHLLRVVEDFIHLVGDALKAFQSSLIVTDNLVISIQREPISAVSSDITFPMRGRRGMKDWVRHSEDRLFLPKEVLSLSSPGKPATPGAATAGSPGRGRGPGTVPPGPGHAHQRLLPADPEESSSYFVIGAVLYRTLGLILPPPRPPLAVTSRVMTVTVRPPTQPPAEPLITVELSYIINGTTDPHCASWDYSRADTNSGDWNTESCQTLETQAAHTRCQCQHLSTFAVLAQPPKDLTLELAGAPSVPLVIGCAVSCMALLTLLAIYAAFWRFIKSERSIILLNFCLSILASNILILVGQSRVLSKGVCTMTAAFLHFFFLSSFCWVLTEAWQSYLAVIGRMRTRLVRKRFLCLGWGLPALVVAVSVGFTRTKGYGTSSYCWLSLEGGLLYAFVGPAAVIVLVNMLIGIIVFNKLMARDGVSDKSKKQRAGSERCPWASLLLPCSACGAVPSPLLSSASARNAMASLWSSCVVLPLLALTWMSAVLAMTDRRSVLFQALFAVFNSAQGFVITAVHCFLRREVQDVVKCQMGVCRADESEDSPDSCKNGQLQILSDFEKDVDLACQTVLFKEVNTCNPSTITGTLSRLSLDEDEEPKSCLVGPEGGLSFSPLPGNILVPMAASPGLGEPPPPQETNPVYMCGEGGLRQLDLTWIRQSEPGSEGDYMVLPRRTLSLQPGGGGTAGEEAPRARPEGTPRRAAKTVAHTEGYPSFLSVEHSGLGLGPAYGSLQNPYGMTFQPPPPTPSARQVPEPGERSRTMPRTVPGSTMKLGSLERKKLRYSDLDFEKVMHTRKRHSELYHELNQKFHTFDRYRSQSSAKEKPSPPGGRPGLSQHRRHQSWSTFKSMTLGSLPPKPRERLALHRTAAWEPTEPPDGDFQTEV
uniprot
proteins
function
FUNCTION: Orphan G protein-coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G protein GNAZ. Involved in angiogenesis inhibition (PubMed:12218411). {ECO:0000250|UniProtKB:O60241, ECO:0000269|PubMed:12218411}.
uniprot
proteins
mass_dalton
169863
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:O60241}.; PTM: Autoproteolytically processed at the GPS region of the GAIN-B domain; this cleavage modulates receptor activity (By similarity). Additionally, furin is involved in the cleavage at another site, in the middle of the extracellular domain, generating a soluble fragment. {ECO:0000255|PROSITE-ProRule:PRU00098}.
uniprot
proteins
protein_family
Adhesion G protein-coupled receptor (ADGR) subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
12218411
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16412436
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21110148
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28891236
uniprot
proteins
sequence_length
1561
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O60241}; Multi-pass membrane protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:O60241}.
uniprot
proteins
transmembrane_region
TRANSMEM 931..951; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 960..980; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 989..1009; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 1031..1051; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 1073..1093; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 1116..1136; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 1148..1168; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins