RANBP10
entrez
57610
canonical
uniprot
Q6VN20
canonical
ensembl
ENSG00000141084
resolver
ensp
ENSP00000316589
resolver
ensp
ENSP00000392808
resolver
ensp
ENSP00000473396
resolver
enst
ENST00000602677
resolver
genesymbol
RANBP10
resolver
genesymbol_syn
KIAA1464
resolver
hgnc
HGNC:29285
resolver
uniprot
A4FTY2
resolver
uniprot
B3KP49
resolver
uniprot
B4DID0
resolver
uniprot
B4DQH9
resolver
uniprot
E7EW27
resolver
uniprot
Q9P264
resolver
uniprot
R4GMX8
resolver
uniprot_entry
B3KP49_HUMAN
resolver
uniprot_entry
R4GMX8_HUMAN
resolver
uniprot_entry
RBP10_HUMAN
resolver
uniprot_sec
A4FTY2
resolver
uniprot_sec
B4DID0
resolver
uniprot_sec
B4DQH9
resolver
uniprot_sec
E7EW27
resolver
uniprot_sec
Q9P264
resolver
amino_acid_sequence
MAAATADPGAGNPQPGDSSGGGAGGGLPSPGEQELSRRLQRLYPAVNQQETPLPRSWSPKDKYNYIGLSQGNLRVHYKGHGKNHKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINGTCFYTKNGHSLGIAFTDLPANLYPTVGLQTPGEIVDANFGQQPFLFDIEDYMREWRAKVQGTVHCFPISARLGEWQAVLQNMVSSYLVHHGYCATATAFARMTETPIQEEQASIKNRQKIQKLVLEGRVGEAIETTQRFYPGLLEHNPNLLFMLKCRQFVEMVNGTDSEVRSLSSRSPKSQDSYPGSPSLSPRHGPSSSHMHNTGADSPSCSNGVASTKSKQNHSKYPAPSSSSSSSSSSSSSSPSSVNYSESNSTDSTKSQHHSSTSNQETSDSEMEMEAEHYPNGVLGSMSTRIVNGAYKHEDLQTDESSMDDRHPRRQLCGGNQAATERIILFGRELQALSEQLGREYGKNLAHTEMLQDAFSLLAYSDPWSCPVGQQLDPIQREPVCAALNSAILESQNLPKQPPLMLALGQASECLRLMARAGLGSCSFARVDDYLH
uniprot
proteins
function
FUNCTION: May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). {ECO:0000250|UniProtKB:Q6VN19, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:29911972, ECO:0000305}.
uniprot
proteins
mass_dalton
67257
uniprot
proteins
protein_family
RANBP9/10 family
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
14684163
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
18222118
uniprot
proteins
pubmed
18347012
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20580816
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29911972
uniprot
proteins
sequence_length
620
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18222118}. Nucleus {ECO:0000269|PubMed:18222118}. Note=Predominantly cytoplasmic.
uniprot
proteins