PLA2G2D
entrez
26279
canonical
uniprot
Q9UNK4
canonical
ensembl
ENSG00000117215
resolver
ensp
ENSP00000364246
resolver
ensp
ENSP00000482871
resolver
genesymbol
PLA2G2D
resolver
genesymbol_syn
SPLASH
resolver
hgnc
HGNC:9033
resolver
uniprot
A0A087WZT4
resolver
uniprot
A8K2Z1
resolver
uniprot
B1AEL9
resolver
uniprot
Q9UK01
resolver
uniprot_entry
PA2GD_HUMAN
resolver
uniprot_sec
A0A087WZT4
resolver
uniprot_sec
A8K2Z1
resolver
uniprot_sec
B1AEL9
resolver
uniprot_sec
Q9UK01
resolver
amino_acid_sequence
MELALLCGLVVMAGVIPIQGGILNLNKMVKQVTGKMPILSYWPYGCHCGLGGRGQPKDATDWCCQTHDCCYDHLKTQGCSIYKDYYRYNFSQGNIHCSDKGSWCEQQLCACDKEVAFCLKRNLDTYQKRLRFYWRPHCRGQTPGC
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions (PubMed:10455175, PubMed:10681567). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:10455175). In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins (By similarity). During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response (By similarity). May act in an autocrine and paracrine manner (By similarity). Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance (By similarity). May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (By similarity). {ECO:0000250|UniProtKB:Q9WVF6, ECO:0000269|PubMed:10455175, ECO:0000269|PubMed:10681567}.
uniprot
proteins
mass_dalton
16546
uniprot
proteins
protein_family
Phospholipase A2 family
uniprot
proteins
pubmed
10455175
uniprot
proteins
pubmed
10681567
uniprot
proteins
pubmed
11196711
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
sequence_length
145
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10455175}.
uniprot
proteins