Abcc10
entrez
224814
canonical
uniprot
Q8R4P9
canonical
ensembl
ENSMUSG00000032842
resolver
ensp
ENSMUSP00000038041
resolver
ensp
ENSMUSP00000092895
resolver
ensp
ENSMUSP00000131843
resolver
genesymbol
Abcc10
resolver
genesymbol_syn
Mrp7
resolver
uniprot
Q3TCQ0
resolver
uniprot
Q3V0D1
resolver
uniprot
Q8R4S1
resolver
uniprot_entry
MRP7_MOUSE
resolver
uniprot_sec
Q3TCQ0
resolver
uniprot_sec
Q3V0D1
resolver
uniprot_sec
Q8R4S1
resolver
amino_acid_sequence
MEGLLAQLCGTDAARPLPLWEGDTTGHCFTQLVLSALPHALLAVLSACHLGTPRTTNHSPALNPGWRLRLAASFLLSIFPLLDLLPVVLPPGSRPGPLWLEVLAGCVTAVAWFTHSLALWALVHSPHGRSRGPLALALAAFLPTPALVLTLLWHCQRGTFLPPLLPGPLGRVCLLILQLAAVLAYGLGWAAPGGPQEPWTHDPFLSSESQETEVAEDGESWLSRFSYAWLAPLLARGVRGELQQPRDTCRLPRRLHPAFLARVFQAHWKEGAQLWRALYRAFGCCYLALGLLKMVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYVLGLAGGTVISAVLQNQYGYEVRKVTLQARVAVLSTLYRKALKLGPSRPPTGEVLNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGMAFLAGLVLALLLVPVNKVIATRIMASNQEMLRHKDARVKLMTELLSGIRVIKFFRWEQALGDRVKACRTKELGRLRVIKYLDAACVYLWAALPVVICITIFITYVLMGHQLTATKVFTALALVRMLILPLNNFPWVINGLLESKVSLDRIQRFLDLPSYSPEAYYSPDPPAEPSTALELHEALFSWDPIGASQKTFISHLQVKKGMLVGIVGKVGCGKSSLLAAITGELHRLCGWVAVSELSKGFGLATQEPWIQCATIRDNILFGKTFDAQLYREVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKALYLLDDPLAAVDADVANHLLHRCILGVLSHTTRLLCTHRTEYLERADVVLLMEAGQLVRTGPPSEILPLVQAVPTAWAEKEQVATSGQSPSVCDLERTTEEELEVEQSTCGCLVQEESKSEGAVALHVYRAYWRAMGSGLAAAILVSLLLMQATRNGADWWLAHWLSQLKAGRNGSREDPASCSPGSTALFSPRLLLFSPGNLYTPLLSTPLHKAASNGTADVHFYLIVYATIAGVNSLCTLLRAVLFAAGALQAAASLHHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFLLNILLANSVGLLGLLAVLGSGLPWLLLLLPPLSFVYYSVQGYYRASFRELRRLGSLTWSPLYSHLADTLAGLPVLRAAGATYRFEEENQRLLELNQRCQFASYATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLVLSYALSLTGLLSGLVSSFTQTEAMMVSVERLEEYSCDVPQEPHSQPLQSPHQQRISWLTQGSVEFQDVVLVYRPGLPNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPNAGRVLLDNVDTSQLELAELRSQLAVIPQEPFLFSGTIRENLDPQGLHEDRALWQALEQCHLSEVAVAMGGLDGELGERGQNLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPSALRNQPHSLFQQLLQSSQQGAHSGPSGC
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
ec_number
7.6.2.3
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity). Mediates intercellular propagation of antiviral immune signaling in early stages of infection (PubMed:40010341). In RNA virus-infected cells, oligoadenylate synthase senses viral dsRNA and generates 2',5'-oligoadenylates (2-5A) which act as second messengers to activate RNASEL and type I interferon signaling to inhibit viral replicationPubMed:40010341 (PubMed:40010341). This innate signaling pathway is locally extended and amplified by ABCC10, which exports 2-5A from virus-infected cells to cross-activates RNASEL in uninfected neighboring cells and confers protection against viral infection (PubMed:40010341). {ECO:0000250|UniProtKB:Q5T3U5, ECO:0000269|PubMed:40010341}.
uniprot
proteins
mass_dalton
163735
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCC family
uniprot
proteins
protein_family
Conjugate transporter (TC 3.A.1.208) subfamily
uniprot
proteins
pubmed
11943485
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21576088
uniprot
proteins
pubmed
40010341
uniprot
proteins
sequence_length
1501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5T3U5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5T3U5, ECO:0000255|PROSITE-ProRule:PRU00441}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q5T3U5}; Multi-pass membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000250|UniProtKB:Q5T3U5}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 70..90; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 102..122; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 133..153; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 294..314; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 321..341; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 392..412; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 415..435; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 508..528; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 539..559; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 877..897; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 969..989; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1033..1053; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1056..1076; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1158..1178; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1187..1207; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins