PPP1R15A
entrez
23645
canonical
uniprot
O75807
canonical
ensembl
ENSG00000087074
resolver
ensp
ENSP00000200453
resolver
genesymbol
PPP1R15A
resolver
genesymbol_syn
GADD34
resolver
hgnc
HGNC:14375
resolver
uniprot
B4DKQ3
resolver
uniprot
Q6IA96
resolver
uniprot
Q9NVU6
resolver
uniprot_entry
PR15A_HUMAN
resolver
uniprot_sec
B4DKQ3
resolver
uniprot_sec
Q6IA96
resolver
uniprot_sec
Q9NVU6
resolver
amino_acid_sequence
MAPGQAPHQATPWRDAHPFFLLSPVMGLLSRAWSRLRGLGPLEPWLVEAVKGAALVEAGLEGEARTPLAIPHTPWGRRPEEEAEDSGGPGEDRETLGLKTSSSLPEAWGLLDDDDGMYGEREATSVPRGQGSQFADGQRAPLSPSLLIRTLQGSDKNPGEEKAEEEGVAEEEGVNKFSYPPSHRECCPAVEEEDDEEAVKKEAHRTSTSALSPGSKPSTWVSCPGEEENQATEDKRTERSKGARKTSVSPRSSGSDPRSWEYRSGEASEEKEEKAHKETGKGEAAPGPQSSAPAQRPQLKSWWCQPSDEEEGEVKALGAAEKDGEAECPPCIPPPSAFLKAWVYWPGEDTEEEEDEEEDEDSDSGSDEEEGEAEASSSTPATGVFLKSWVYQPGEDTEEEEDEDSDTGSAEDEREAETSASTPPASAFLKAWVYRPGEDTEEEEDEDVDSEDKEDDSEAALGEAESDPHPSHPDQRAHFRGWGYRPGKETEEEEAAEDWGEAEPCPFRVAIYVPGEKPPPPWAPPRLPLRLQRRLKRPETPTHDPDPETPLKARKVRFSEKVTVHFLAVWAGPAQAARQGPWEQLARDRSRFARRITQAQEELSPCLTPAARARAWARLRNPPLAPIPALTQTLPSSSVPSSPVQTTPLSQAVATPSRSSAAAAAALDLSGRRG
uniprot
proteins
function
FUNCTION: Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress (PubMed:26095357, PubMed:26742780). Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1 (PubMed:14718519). May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15' (PubMed:14635196). Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux (PubMed:32978159). Also acts a viral restriction factor by attenuating HIV-1 and influenza A virus replication (PubMed:31778897, PubMed:41747053). Mechanistically, mediates the inhibition of HIV-1 TAR RNA-mediated translation (PubMed:31778897). Mediates the inhibition of influenza A virus RNA polymerase (PubMed:41747053). {ECO:0000269|PubMed:11564868, ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:14635196, ECO:0000269|PubMed:14718519, ECO:0000269|PubMed:26095357, ECO:0000269|PubMed:26742780, ECO:0000269|PubMed:31778897, ECO:0000269|PubMed:41747053, ECO:0000269|PubMed:8139541}.; FUNCTION: (Microbial infection) Promotes enterovirus 71 replication by mediating the internal ribosome entry site (IRES) activity of viral 5'-UTR. {ECO:0000269|PubMed:34985336}.
uniprot
proteins
mass_dalton
73478
uniprot
proteins
mutagenesis
MUTAGEN 25; /note="V->R: Localizes to cytoplasm, degraded more slowly."; /evidence="ECO:0000269|PubMed:21518769"; MUTAGEN 29; /note="L->R: Localizes to cytoplasm."; /evidence="ECO:0000269|PubMed:21518769"; MUTAGEN 262; /note="Y->F: Significantly reduced turnover."; /evidence="ECO:0000269|PubMed:24092754"; MUTAGEN 555..558; /note="KVRF->AAAA: Reduces interaction with SMARCB1."; /evidence="ECO:0000269|PubMed:12016208"; MUTAGEN 556..558; /note="VRF->ARA: Impairs PP1 activation."; /evidence="ECO:0000269|PubMed:12556489"; MUTAGEN 612; /note="R->K: Reduces PP1-binding; when associated with K-614."; /evidence="ECO:0000269|PubMed:12556489"; MUTAGEN 614; /note="R->K: Reduces PP1-binding; when associated with K-612."; /evidence="ECO:0000269|PubMed:12556489"; MUTAGEN 618; /note="R->D: Reduces PP1-binding."; /evidence="ECO:0000269|PubMed:12556489
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at multiple Ser/Thr residues. Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity. Phosphorylation at Tyr-262 enhances proteasomal degradation, this position is dephosphorylated by PTPN2. {ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:24092754}.; PTM: Polyubiquitinated. Exhibits a rapid proteasomal degradation with a half-life under 1 hour, ubiquitination depends on endoplasmic reticulum association. {ECO:0000269|PubMed:24092754}.
uniprot
proteins
protein_family
PPP1R15 family
uniprot
proteins
pubmed
10490642
uniprot
proteins
pubmed
11517336
uniprot
proteins
pubmed
11564868
uniprot
proteins
pubmed
12016208
uniprot
proteins
pubmed
12114539
uniprot
proteins
pubmed
12556489
uniprot
proteins
pubmed
12724406
uniprot
proteins
pubmed
14635196
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14718519
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15705855
uniprot
proteins
pubmed
19131336
uniprot
proteins
pubmed
21518769
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24092754
uniprot
proteins
pubmed
26095357
uniprot
proteins
pubmed
26742780
uniprot
proteins
pubmed
31778897
uniprot
proteins
pubmed
32978159
uniprot
proteins
pubmed
34985336
uniprot
proteins
pubmed
41747053
uniprot
proteins
pubmed
8139541
uniprot
proteins
pubmed
9153226
uniprot
proteins
sequence_length
674
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:21518769, ECO:0000269|PubMed:26742780}. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:21518769}. Note=Associates with membranes via an N-terminal amphipathic intramembrane region. {ECO:0000269|PubMed:21518769}.
uniprot
proteins