SEMA5A
entrez
9037
canonical
uniprot
Q13591
canonical
ensembl
ENSG00000112902
resolver
ensp
ENSP00000371936
resolver
ensp
ENSP00000499013
resolver
ensp
ENSP00000567655
resolver
ensp
ENSP00000567656
resolver
ensp
ENSP00000567657
resolver
ensp
ENSP00000567658
resolver
ensp
ENSP00000567660
resolver
ensp
ENSP00000567662
resolver
enst
ENST00000382496
resolver
enst
ENST00000652226
resolver
enst
ENST00000897596
resolver
enst
ENST00000897597
resolver
enst
ENST00000897598
resolver
enst
ENST00000897599
resolver
enst
ENST00000897601
resolver
enst
ENST00000897603
resolver
genesymbol
SEMA5A
resolver
genesymbol_syn
SEMAF
resolver
hgnc
HGNC:10736
resolver
uniprot
D3DTC6
resolver
uniprot
O60408
resolver
uniprot
Q1RLL9
resolver
uniprot
X5DR95
resolver
uniprot_entry
SEM5A_HUMAN
resolver
uniprot_entry
X5DR95_HUMAN
resolver
uniprot_sec
D3DTC6
resolver
uniprot_sec
O60408
resolver
uniprot_sec
Q1RLL9
resolver
amino_acid_sequence
MKGTCVIAWLFSSLGLWRLAHPEAQGTTQCQRTEHPVISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLSMTQWEQSISACPTRNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHMFWTGWGPWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSCNTNPCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCPESWSEWSDWSECEASGVQVRARQCILLFPMGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMIAVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAPLNTSITNHINKLDKYDSVEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY
uniprot
proteins
function
FUNCTION: Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. {ECO:0000250, ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:19850054, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}.
uniprot
proteins
mass_dalton
120615
uniprot
proteins
protein_family
Semaphorin family
uniprot
proteins
pubmed
15218527
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19850054
uniprot
proteins
pubmed
20696765
uniprot
proteins
pubmed
21706053
uniprot
proteins
pubmed
26637798
uniprot
proteins
pubmed
9464278
uniprot
proteins
sequence_length
1074
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 969..989; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins