SERPINB3
entrez
6317
canonical
uniprot
P29508
canonical
ensembl
ENSG00000057149
resolver
ensp
ENSP00000283752
resolver
genesymbol
SERPINB3
resolver
genesymbol_syn
SCCA
resolver
genesymbol_syn
SCCA1
resolver
hgnc
HGNC:10569
resolver
uniprot
A6NDM2
resolver
uniprot
B2RBT5
resolver
uniprot
B3W5Y6
resolver
uniprot
Q53H28
resolver
uniprot
Q53YB5
resolver
uniprot
Q86VF3
resolver
uniprot
Q86W04
resolver
uniprot
Q8IWL4
resolver
uniprot
Q8IXI3
resolver
uniprot
Q96J21
resolver
uniprot
Q9BYF8
resolver
uniprot_entry
SPB3_HUMAN
resolver
uniprot_sec
A6NDM2
resolver
uniprot_sec
B2RBT5
resolver
uniprot_sec
B3W5Y6
resolver
uniprot_sec
Q53H28
resolver
uniprot_sec
Q53YB5
resolver
uniprot_sec
Q86VF3
resolver
uniprot_sec
Q86W04
resolver
uniprot_sec
Q8IWL4
resolver
uniprot_sec
Q8IXI3
resolver
uniprot_sec
Q96J21
resolver
uniprot_sec
Q9BYF8
resolver
amino_acid_sequence
MNSLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQVTENTTGKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGMTGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFGSSPTSTNEEFHCNHPFLFFIRQNKTNSILFYGRFSSP
uniprot
proteins
function
FUNCTION: May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). {ECO:0000269|PubMed:19166818}.
uniprot
proteins
mass_dalton
44565
uniprot
proteins
mutagenesis
MUTAGEN 341; /note="A->R: Loss of inhibitory activity."; /evidence="ECO:0000269|PubMed:12975381"; MUTAGEN 352; /note="F->A: Loss of inhibitory activity."; /evidence="ECO:0000269|PubMed:12975381, ECO:0000269|PubMed:19166818"; MUTAGEN 352; /note="F->G: Loss of inhibitory activity to papain but does not decrease the suppression activity to MAPK8."; /evidence="ECO:0000269|PubMed:12975381, ECO:0000269|PubMed:19166818"; MUTAGEN 354..355; /note="SS->PP: Loss of inhibitory activity."; /evidence="ECO:0000269|PubMed:12975381
uniprot
proteins
protein_family
Ov-serpin subfamily
uniprot
proteins
protein_family
Serpin family
uniprot
proteins
pubmed
10956412
uniprot
proteins
pubmed
12975381
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14970861
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
19166818
uniprot
proteins
pubmed
1958219
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21383048
uniprot
proteins
pubmed
7724531
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10956412, ECO:0000269|PubMed:14970861}. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.
uniprot
proteins