Mrgprd
entrez
293648
canonical
uniprot
Q7TN41
canonical
ensembl
ENSRNOG00000013448
resolver
ensembl
ENSRNOG00055020895
resolver
ensembl
ENSRNOG00060032232
resolver
ensembl
ENSRNOG00065030273
resolver
ensp
ENSRNOP00000017958
resolver
ensp
ENSRNOP00000099226
resolver
ensp
ENSRNOP00000110296
resolver
ensp
ENSRNOP00000110558
resolver
ensp
ENSRNOP00055028909
resolver
ensp
ENSRNOP00060046198
resolver
ensp
ENSRNOP00065042958
resolver
enst
ENSRNOT00000017958
resolver
enst
ENSRNOT00000122516
resolver
enst
ENSRNOT00000145954
resolver
enst
ENSRNOT00000152841
resolver
enst
ENSRNOT00055035651
resolver
enst
ENSRNOT00060055851
resolver
enst
ENSRNOT00065052221
resolver
genesymbol
Mrgprd
resolver
genesymbol_syn
Mrgd
resolver
uniprot
Q6L788
resolver
uniprot_entry
MRGRD_RAT
resolver
uniprot_sec
Q6L788
resolver
amino_acid_sequence
MNYTPYSSPAPGLTISPTMDPVTWVYFSVTFLAMATCVCGIVGNSMVIWLLSFHRVQRSPFCTYVLNLAVADLLFLLCMASLLSLETGPLLTASTSARVYEGMKRIKYFAYTAGLSLLTAISTQRCLSVLFPIWYKCHRPQHLSGVVCGVLWALALLMNFLASFFCVQFWHPDKYQCFKVDMVFNSLILGIFMPVMVLTSAIIFIRMRKNSLLQRRQPRRLYVVILTSVLVFLTCSLPLGINWFLLYWVELPQAVRLLYVCSSRFSSSLSSSANPVIYFLVGSQKSHRLQESLGAVLGRALQDEPEGRETPSTCTNDGV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that acts as a mediator of peripheral pain and itch sensations. Activated by various ligands, such as beta-alanine, beta-aminoisobutyrate, angiotensin 1-7, alamandine and allantoin, causing a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). MRGPRD is both coupled to G(q) and G(i) G proteins: G(q) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, while G(i) coupling mediates inhibition of adenylate cyclase activity (By similarity). MRGPRD is specifically expressed in neurons that innervate the epidermis and acts as a key mediator of skin stimuli, such as itch, pain and mechanical stimuli. Required to maintain skin homeostasis in response to irritant dermatitis by initiating a signaling that promotes glutamate release, inhibiting mast cell hyperresponsiveness and skin inflammation. Required to prevent cardiomyocyte hypertrophy following activation by alamandine, a decarboxylation product of angiotensin 1-7. Acts as a receptor for allantoin in dorsal root ganglion neurons, eliciting chronic itch (pruritus) (By similarity). {ECO:0000250|UniProtKB:Q8TDS7, ECO:0000250|UniProtKB:Q91ZB8}.
uniprot
proteins
mass_dalton
35830
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Mas subfamily
uniprot
proteins
pubmed
12909716
uniprot
proteins
pubmed
15037633
uniprot
proteins
sequence_length
319
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q91ZB8}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine. {ECO:0000250|UniProtKB:Q8TDS7}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..49; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q8TDS7"; TRANSMEM 62..88; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q8TDS7"; TRANSMEM 98..127; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q8TDS7"; TRANSMEM 143..167; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q8TDS7"; TRANSMEM 179..205; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q8TDS7"; TRANSMEM 222..246; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q8TDS7"; TRANSMEM 257..281; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q8TDS7
uniprot
proteins