HOXA9
entrez
3205
canonical
uniprot
P31269
canonical
ensembl
ENSG00000078399
resolver
ensp
ENSP00000343619
resolver
enst
ENST00000343483
resolver
genesymbol
HOXA9
resolver
genesymbol_syn
HOX1G
resolver
hgnc
HGNC:5109
resolver
uniprot
O43369
resolver
uniprot
O43429
resolver
uniprot
Q99820
resolver
uniprot_entry
HXA9_HUMAN
resolver
uniprot_sec
O43369
resolver
uniprot_sec
O43429
resolver
uniprot_sec
Q99820
resolver
amino_acid_sequence
MATTGALGNYYVDSFLLGADAADELSVGRYAPGTLGQPPRQAATLAEHPDFSPCSFQSKATVFGASWNPVHAAGANAVPAAVYHHHHHHPYVHPQAPVAAAAPDGRYMRSWLEPTPGALSFAGLPSSRPYGIKPEPLSARRGDCPTLDTHTLSLTDYACGSPPVDREKQPSEGAFSENNAENESGGDKPPIDPNNPAANWLHARSTRKKRCPYTKHQTLELEKEFLFNMYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKINKDRAKDE
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98 (PubMed:8563753). The chimera includes NUP98 intrinsic disordered regions which contribute to aberrant liquid-liquid phase separation puncta of the chimera in the nucleus. This phase-separation enhances the chimera genomic targeting and induces organization of aberrant three-dimensional chromatin structures leading to tumourous transformation (PubMed:34163069). {ECO:0000269|PubMed:34163069, ECO:0000269|PubMed:8563753}.; DISEASE: Note=A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2.
uniprot
proteins
function
FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cells surface at sites of inflammation (PubMed:22269951). Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (By similarity). {ECO:0000250|UniProtKB:P09631, ECO:0000269|PubMed:22269951}.
uniprot
proteins
mass_dalton
30172
uniprot
proteins
mutagenesis
MUTAGEN 140; /note="R->A: Results in loss of methylation."; /evidence="ECO:0000269|PubMed:22269951
uniprot
proteins
post_translational_modification
PTM: Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction. {ECO:0000269|PubMed:22269951}.
uniprot
proteins
protein_family
Abd-B homeobox family
uniprot
proteins
pubmed
12649177
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15657436
uniprot
proteins
pubmed
22269951
uniprot
proteins
pubmed
2574852
uniprot
proteins
pubmed
34163069
uniprot
proteins
pubmed
8563753
uniprot
proteins
pubmed
8563754
uniprot
proteins
pubmed
9880515
uniprot
proteins
sequence_length
272
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15657436}. Cytoplasm {ECO:0000269|PubMed:15657436}.
uniprot
proteins