CACFD1
entrez
11094
canonical
uniprot
Q9UGQ2
canonical
ensembl
ENSG00000160325
resolver
ensembl
ENSG00000280479
resolver
ensp
ENSP00000291722
resolver
ensp
ENSP00000317121
resolver
ensp
ENSP00000440832
resolver
ensp
ENSP00000444328
resolver
genesymbol
CACFD1
resolver
genesymbol_syn
C9orf7
resolver
hgnc
HGNC:1365
resolver
uniprot
B7Z3T8
resolver
uniprot
B7Z5E1
resolver
uniprot
F5GXX4
resolver
uniprot
Q5SXD4
resolver
uniprot
Q8NBM6
resolver
uniprot_entry
FLOWR_HUMAN
resolver
uniprot_sec
B7Z3T8
resolver
uniprot_sec
B7Z5E1
resolver
uniprot_sec
F5GXX4
resolver
uniprot_sec
Q5SXD4
resolver
uniprot_sec
Q8NBM6
resolver
amino_acid_sequence
MSSSGGAPGASASSAPPAQEEGMTWWYRWLCRLSGVLGAVSCAISGLFNCITIHPLNIAAGVWMIMNAFILLLCEAPFCCQFIEFANTVAEKVDRLRSWQKAVFYCGMAVVPIVISLTLTTLLGNAIAFATGVLYGLSALGKKGDAISYARIQQQRQQADEEKLAETLEGEL
uniprot
proteins
function
FUNCTION: Transmembrane protein which mediates synaptic endocytosis and fitness-based cell culling (PubMed:31341286, PubMed:37348560). In response to different stimulus strengths, controls two major modes of synaptic vesicle (SV) retrieval in hippocampal neurons; Clathrin-mediated endocytosis (CME) in response to mild stimulation and activity-dependent bulk endocytosis (ADBE) in response to strong stimulation (By similarity). In cytotoxic T-lymphocytes (CTLs) facilitates calcium-dependent endocytosis of cytotoxic granules at the immuno synapse (By similarity). Different isoforms work as fitness fingerprints in 'loser' and 'winner' cells and thereby mediate win/lose decisions as part of the cell competition process (PubMed:31341286). {ECO:0000250|UniProtKB:D4A9I3, ECO:0000250|UniProtKB:Q8BG21, ECO:0000269|PubMed:31341286, ECO:0000269|PubMed:37348560}.; FUNCTION: [Isoform 1]: Functions with the other flower isoforms to produce tissue-specific fitness fingerprints that identify unfit or fit cells during cell selection processes in order to maintain tissue health (PubMed:31341286). During cell competition, if levels of this isoform in cells is higher than in the surrounding neighboring cells, the cells are recognized as 'winner' cells, and do not undergo elimination via apoptosis (PubMed:31341286). {ECO:0000269|PubMed:31341286}.; FUNCTION: [Isoform 2]: Functions with the other flower isoforms to produce tissue-specific fitness fingerprints that identify unfit or fit cells during cell selection processes in order to maintain tissue health (PubMed:31341286). During cell competition, if levels of this isoform in unfit cells is higher than in the surrounding neighboring cells, the cells are recognized as 'loser' cells, and undergo elimination via apoptosis to be replaced by the surrounding healthy 'winner' cell population (PubMed:31341286). {ECO:0000269|PubMed:31341286}.; FUNCTION: [Isoform 3]: Functions with the other flower isoforms to produce tissue-specific fitness fingerprints that identify unfit or fit cells during cell selection processes in order to maintain tissue health (PubMed:31341286). During cell competition, if levels of this isoform in unfit cells is higher than in the surrounding neighboring cells, the cells are recognized as 'loser' cells, and undergo elimination via apoptosis to be replaced by the surrounding healthy 'winner' cell population (PubMed:31341286). {ECO:0000269|PubMed:31341286}.; FUNCTION: [Isoform 4]: Functions with the other flower isoforms to produce tissue-specific fitness fingerprints that identify unfit or fit cells during cell selection processes in order to maintain tissue health (PubMed:31341286). During cell competition, if levels of this isoform in cells is higher than in the surrounding neighboring cells, the cells are recognized as 'winner' cells, and do not undergo elimination via apoptosis (PubMed:31341286). {ECO:0000269|PubMed:31341286}.
uniprot
proteins
mass_dalton
18470
uniprot
proteins
mutagenesis
MUTAGEN 25..30; /note="WWYRWL->AAAAAA: Reduces internalization; when associated with 149-A--A-152."; /evidence="ECO:0000269|PubMed:37348560"; MUTAGEN 149..152; /note="YARI->AAAA: Reduces internalization; when associated with 25-A--A-30."; /evidence="ECO:0000269|PubMed:37348560
uniprot
proteins
protein_family
Calcium channel flower family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
31341286
uniprot
proteins
pubmed
37348560
uniprot
proteins
sequence_length
172
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:D4A9I3}. Golgi apparatus {ECO:0000250|UniProtKB:D4A9I3}. Vesicle {ECO:0000250|UniProtKB:Q8BG21}. Note=In cytotoxic T-lymphocytes, localizes to intracellular vesicles that move to the immuno synapse (By similarity). Enriched in synaptic vesicles at the presynaptic vesicles (By similarity). Detected in the Golgi apparatus of cultured hippocampal neurons (By similarity). {ECO:0000250|UniProtKB:D4A9I3, ECO:0000250|UniProtKB:Q8BG21}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:37348560}; Multi-pass membrane protein {ECO:0000269|PubMed:37348560}. Early endosome {ECO:0000269|PubMed:37348560}. Recycling endosome {ECO:0000269|PubMed:37348560}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:37348560}; Multi-pass membrane protein {ECO:0000269|PubMed:37348560}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..53; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 58..78; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 126..142; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins