RPS6
entrez
6194
canonical
uniprot
P62753
canonical
ensembl
ENSG00000137154
resolver
ensp
ENSP00000369757
resolver
enst
ENST00000380394
resolver
genesymbol
RPS6
resolver
hgnc
HGNC:10429
resolver
uniprot
A2A3R6
resolver
uniprot
P08227
resolver
uniprot
P10660
resolver
uniprot
Q4VBY7
resolver
uniprot
Q8N6Z7
resolver
uniprot_entry
A2A3R6_HUMAN
resolver
uniprot_entry
RS6_HUMAN
resolver
uniprot_sec
P08227
resolver
uniprot_sec
P10660
resolver
uniprot_sec
Q4VBY7
resolver
uniprot_sec
Q8N6Z7
resolver
amino_acid_sequence
MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK
uniprot
proteins
function
FUNCTION: Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17220279, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}.
uniprot
proteins
mass_dalton
28681
uniprot
proteins
mutagenesis
MUTAGEN 137; /note="R->X: Abolishes hydroxylation by KDM8."; /evidence="ECO:0000269|PubMed:29563586"; MUTAGEN 235..236; /note="SS->AA: Abolishes phosphorylation by PASK."; /evidence="ECO:0000269|PubMed:21418524
uniprot
proteins
post_translational_modification
PTM: Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the pre-initiation complex. {ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18974095, ECO:0000269|PubMed:21418524}.; PTM: Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8. {ECO:0000269|PubMed:29563586}.; PTM: Mono-ADP-ribosylation at Glu-35 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation. {ECO:0000269|PubMed:34314702}.
uniprot
proteins
protein_family
Eukaryotic ribosomal protein eS6 family
uniprot
proteins
pubmed
1301164
uniprot
proteins
pubmed
1446836
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17220279
uniprot
proteins
pubmed
17360704
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18974095
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21418524
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23636399
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24524803
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
2840355
uniprot
proteins
pubmed
29563586
uniprot
proteins
pubmed
3279029
uniprot
proteins
pubmed
34314702
uniprot
proteins
pubmed
34516797
uniprot
proteins
pubmed
8706699
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}.
uniprot
proteins