Aanat
entrez
25120
canonical
uniprot
Q64666
canonical
ensembl
ENSRNOG00000011182
resolver
ensembl
ENSRNOG00055029977
resolver
ensembl
ENSRNOG00060030684
resolver
ensembl
ENSRNOG00065004543
resolver
ensp
ENSRNOP00000015221
resolver
ensp
ENSRNOP00055042891
resolver
ensp
ENSRNOP00060044328
resolver
ensp
ENSRNOP00065004594
resolver
enst
ENSRNOT00000015221
resolver
enst
ENSRNOT00055051954
resolver
enst
ENSRNOT00060053316
resolver
enst
ENSRNOT00065006605
resolver
genesymbol
Aanat
resolver
genesymbol_syn
Snat
resolver
uniprot
Q4JL74
resolver
uniprot
Q64553
resolver
uniprot_entry
SNAT_RAT
resolver
uniprot_sec
Q4JL74
resolver
uniprot_sec
Q64553
resolver
amino_acid_sequence
MLSIHPLKPEALHLPLGTSEFLGCQRRHTLPASEFRCLTPEDATSAFEIEREAFISVSGTCPLHLDEIRHFLTLCPELSLGWFEEGCLVAFIIGSLWDKERLTQESLTLHRPGGRTAHLHVLAVHRTFRQQGKGSVLLWRYLHHLGSQPAVRRAVLMCENALVPFYEKFGFQAMGPCAITMGSLTFTELQCSLRCHTFLRRNSGC
uniprot
proteins
ec_number
2.3.1.87
uniprot
proteins
function
FUNCTION: Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. {ECO:0000250|UniProtKB:Q29495}.
uniprot
proteins
mass_dalton
23142
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="Missing: Impaired light-induced proteasomal degradation."; /evidence="ECO:0000269|PubMed:20210853"; MUTAGEN 8; /note="K->R: No effect on light-induced proteasomal degradation; when associated with R-99, R-133 and R-168."; /evidence="ECO:0000269|PubMed:20210853"; MUTAGEN 37; /note="C->A: No effect on light-induced proteasomal degradation."; /evidence="ECO:0000269|PubMed:20210853"; MUTAGEN 61; /note="C->A: No effect on light-induced proteasomal degradation."; /evidence="ECO:0000269|PubMed:20210853"; MUTAGEN 99; /note="K->R: No effect onlight-induced proteasomal degradation; when associated with R-8, R-133 and R-168."; /evidence="ECO:0000269|PubMed:20210853"; MUTAGEN 133; /note="K->R: No effect on light-induced proteasomal degradation; when associated with R-8, R-99 and R-168."; /evidence="ECO:0000269|PubMed:20210853"; MUTAGEN 168; /note="K->R: No effect on proteasomal degradation; when associated with R-8, R-99 and R-133."; /evidence="ECO:0000269|PubMed:20210853
uniprot
proteins
pathway_participation
PATHWAY: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
uniprot
proteins
post_translational_modification
PTM: cAMP-dependent phosphorylation on both N-terminal Thr-29 and C-terminal Ser-203 regulates AANAT activity by promoting interaction with 14-3-3 proteins. {ECO:0000250}.
uniprot
proteins
protein_family
AANAT subfamily
uniprot
proteins
protein_family
Acetyltransferase family
uniprot
proteins
pubmed
11427721
uniprot
proteins
pubmed
16099857
uniprot
proteins
pubmed
19103603
uniprot
proteins
pubmed
20210853
uniprot
proteins
pubmed
7502081
uniprot
proteins
pubmed
8524412
uniprot
proteins
pubmed
8770929
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q16613}.
uniprot
proteins