Sav1
entrez
299116
canonical
uniprot
A4V8B4
canonical
ensembl
ENSRNOG00000005264
resolver
ensembl
ENSRNOG00055009020
resolver
ensembl
ENSRNOG00060006386
resolver
ensembl
ENSRNOG00065006829
resolver
ensp
ENSRNOP00000007314
resolver
ensp
ENSRNOP00055012204
resolver
ensp
ENSRNOP00060007776
resolver
ensp
ENSRNOP00065007862
resolver
enst
ENSRNOT00000007314
resolver
enst
ENSRNOT00055015245
resolver
enst
ENSRNOT00060010477
resolver
enst
ENSRNOT00065010641
resolver
genesymbol
Sav1
resolver
genesymbol_syn
Ww45
resolver
uniprot
B1WBL9
resolver
uniprot_entry
B1WBL9_RAT
resolver
uniprot_entry
SAV1_RAT
resolver
amino_acid_sequence
MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDLCLPESSASAFSASGDGVVSRNQSFLRTPVQRTPHEVMRRESNRLSAPSSYLVRSLADVPREYGSSQSFLTEVNFAVENGDSGSRYFYSDNFFDGQRRRPLGDRAQEDYRYYEYNHDLFQRMPQNQGRHTSGIGRVTATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKRAQYRHPCAPSVPRYDQPPPITYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKLYEAYRQALVTELENRKQRQQWYAQHHGKKFLS
uniprot
proteins
function
FUNCTION: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
45046
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by STK3/MST2 and STK4/MST1. Phosphorylation is not required for SAV1 stability and may increase the number of protein binding sites on the scaffold molecule (By similarity). {ECO:0000250}.
uniprot
proteins
sequence_length
387
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
uniprot
proteins