Cyc1
entrez
66445
canonical
uniprot
Q9D0M3
canonical
ensembl
ENSMUSG00000022551
resolver
ensp
ENSMUSP00000023210
resolver
genesymbol
Cyc1
resolver
uniprot
Q3TDC5
resolver
uniprot
Q3UAN2
resolver
uniprot
Q63ZW4
resolver
uniprot
Q9DCG0
resolver
uniprot_entry
CY1_MOUSE
resolver
uniprot_sec
Q3TDC5
resolver
uniprot_sec
Q3UAN2
resolver
uniprot_sec
Q63ZW4
resolver
uniprot_sec
Q9DCG0
resolver
amino_acid_sequence
MAAAAASLRRTVLGPRGVGLPGASAPGLLGGARSRQLPLRTPQAVSLSSKSGPSRGRKVMLSALGMLAAGGAGLAVALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCSSCHSMDYVAYRHLVGVCYTEEEAKALAEEVEVQDGPNDDGEMFMRPGKLSDYFPKPYPNPEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIGMAPPIYTEVLEYDDGTPATMSQVAKDVATFLRWASEPEHDHRKRMGLKMLLMMGLLLPLTYAMKRHKWSVLKSRKLAYRPPK
uniprot
proteins
ec_number
7.1.1.8
uniprot
proteins
function
FUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c. {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}.
uniprot
proteins
mass_dalton
35328
uniprot
proteins
protein_family
Cytochrome c family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19026783
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32973183
uniprot
proteins
pubmed
34616041
uniprot
proteins
pubmed
38575788
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}; Single-pass membrane protein {ECO:0000269|PubMed:34616041}.
uniprot
proteins
transmembrane_region
TRANSMEM 288..308; /note="Helical"; /evidence="ECO:0000269|PubMed:34616041, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C
uniprot
proteins