Gpi
entrez
14751
canonical
uniprot
P06745
canonical
ensembl
ENSMUSG00000036427
resolver
ensp
ENSMUSP00000049355
resolver
enst
ENSMUST00000038027
resolver
genesymbol
Gpi
resolver
genesymbol_syn
Gpi1
resolver
uniprot
O89062
resolver
uniprot
Q3TEE7
resolver
uniprot
Q3TW50
resolver
uniprot
Q3UUX1
resolver
uniprot
Q3UY84
resolver
uniprot
Q3UZJ1
resolver
uniprot
Q5RJI3
resolver
uniprot
Q8C675
resolver
uniprot
Q9JM07
resolver
uniprot_entry
G6PI_MOUSE
resolver
uniprot_sec
O89062
resolver
uniprot_sec
Q3TEE7
resolver
uniprot_sec
Q3TW50
resolver
uniprot_sec
Q3UUX1
resolver
uniprot_sec
Q3UY84
resolver
uniprot_sec
Q3UZJ1
resolver
uniprot_sec
Q5RJI3
resolver
uniprot_sec
Q8C675
resolver
uniprot_sec
Q9JM07
resolver
amino_acid_sequence
MAALTRNPQFQKLLEWHRANSANLKLRELFEADPERFNNFSLNLNTNHGHILVDYSKNLVNKEVMQMLVELAKSRGVEAARDNMFSGSKINYTENRAVLHVALRNRSNTPIKVDGKDVMPEVNRVLDKMKSFCQRVRSGDWKGYTGKSITDIINIGIGGSDLGPLMVTEALKPYSKGGPRVWFVSNIDGTHIAKTLASLSPETSLFIIASKTFTTQETITNAETAKEWFLEAAKDPSAVAKHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDHFEQLLSGAHWMDQHFLKTPLEKNAPVLLALLGIWYINCYGCETHALLPYDQYMHRFAAYFQQGDMESNGKYITKSGARVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMKGKLPEEARKELQAAGKSPEDLEKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGIMWDINSFDQWGVELGKQLAKKIEPELEGSSAVTSHDSSTNGLISFIKQQRDTKLE
uniprot
proteins
ec_number
5.1.3.-
uniprot
proteins
ec_number
5.3.1.9
uniprot
proteins
function
FUNCTION: Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm (PubMed:2344351, PubMed:7277315, PubMed:8417789). Also shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) and D-mannose-6-phosphate (M6P) (By similarity). Also displays anomerase activity, interconverting alpha and beta-anomeric forms of G6P, D-fructose-6-phosphate and M6P (By similarity). In addition to its metabolic role, this enzyme functions extracellularly as a cytokine: acts as autocrine motility factor (AMF), a secreted angiogenic factor that enhances endothelial cell motility (By similarity). Functions as neuroleukin, a neurotrophic factor supporting the survival of spinal and sensory neurons (PubMed:3352745, PubMed:3764429). Released by lectin-stimulated T-cells to induce immunoglobulin secretion (PubMed:3352745). {ECO:0000250|UniProtKB:P06744, ECO:0000250|UniProtKB:P12709, ECO:0000250|UniProtKB:Q9N1E2, ECO:0000269|PubMed:2344351, ECO:0000269|PubMed:3352745, ECO:0000269|PubMed:3764429, ECO:0000269|PubMed:7277315, ECO:0000269|PubMed:8417789}.
uniprot
proteins
mass_dalton
62767
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. {ECO:0000269|PubMed:2344351, ECO:0000269|PubMed:7277315, ECO:0000269|PubMed:8417789}.
uniprot
proteins
post_translational_modification
PTM: ISGylated. {ECO:0000269|PubMed:16139798}.
uniprot
proteins
protein_family
GPI family
uniprot
proteins
pubmed
15342241
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16139798
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16375918
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2344351
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
3352745
uniprot
proteins
pubmed
3764429
uniprot
proteins
pubmed
7277315
uniprot
proteins
pubmed
7545951
uniprot
proteins
pubmed
8417789
uniprot
proteins
pubmed
8674049
uniprot
proteins
pubmed
8922529
uniprot
proteins
pubmed
9798653
uniprot
proteins
sequence_length
558
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P06744}. Secreted {ECO:0000250|UniProtKB:P06744}.
uniprot
proteins