Trpv5
entrez
194352
canonical
uniprot
P69744
canonical
ensembl
ENSMUSG00000036899
resolver
ensp
ENSMUSP00000031901
resolver
enst
ENSMUST00000031901
resolver
genesymbol
Trpv5
resolver
uniprot
Q2TB50
resolver
uniprot_entry
TRPV5_MOUSE
resolver
uniprot_sec
Q2TB50
resolver
activity_regulation
ACTIVITY REGULATION: Activated by WNK3. {ECO:0000250|UniProtKB:Q9NQA5}.
uniprot
proteins
amino_acid_sequence
MGAKTPWIQLQKLLNWWVRDQDWNQHVDQLHMLQQKSIWESPLLRAAKENDMCTLKKLQHDQNCDFRQRGALGETALHVAALYDNLDAAIMLMEAAPYLVTESTLCEPFVGQTALHIAVMNQNVNLVRALLARGASASARATGSAFHRSSHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNTVMFQHLMQKRKRIQWSFGPLTSSLYDLTEIDSWGEELSFLELVVSSKKKEARQILEQTPVKELVSLKWKKYGQPYFCLLGALYIFYMVCFTTCCVYRPLKFRDANRTHVRDNTIMEQKSLQEAYVTYQDKIRLVGELVTVIGAVIILLLEIPDIFRVGASRYFGQTVLGGPFHVIIITYASLVLLTMAMRLTNVNGEVVPMSMALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLLRFCWLMAMVILGFASAFYIIFQTEDPDNLGEFSDYPTAMFSTFELFLTIIDGPANYRVDLPFMYSVTYATFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPRSGICGCEYGLGDRWFLRVEHHQEQNPYRVLRYVEAFKSSDKEEVQEQLSEKQPSGTETGTLARGSVVLQTPPLSRTTSLSSNSHRGWEILRRNTLGHLNLGLDPGEGDGEEIYQF
uniprot
proteins
function
FUNCTION: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:12077127, PubMed:14679186). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (PubMed:14679186). The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (PubMed:12077127). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250|UniProtKB:Q9XSM3, ECO:0000269|PubMed:12077127, ECO:0000269|PubMed:14679186}.
uniprot
proteins
mass_dalton
82218
uniprot
proteins
mutagenesis
MUTAGEN 403..406; /note="VGAS->LGVT: Induces faster Ca(2+)-dependent channel inactivation."; /evidence="ECO:0000269|PubMed:12077127"; MUTAGEN 593; /note="T->A: Abolishes interaction with S100A10, plasma membrane localization and channel activity."; /evidence="ECO:0000269|PubMed:12660155
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q9NQA5}.
uniprot
proteins
protein_family
TRPV5 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
protein_family
TrpV subfamily
uniprot
proteins
pubmed
12077127
uniprot
proteins
pubmed
12574114
uniprot
proteins
pubmed
12660155
uniprot
proteins
pubmed
14679186
uniprot
proteins
pubmed
15123711
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16380433
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27102152
uniprot
proteins
sequence_length
723
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:12660155}; Multi-pass membrane protein {ECO:0000269|PubMed:12660155}. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells. {ECO:0000269|PubMed:12660155}.
uniprot
proteins
transmembrane_region
TRANSMEM 321..341; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3"; TRANSMEM 379..401; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3"; TRANSMEM 413..435; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3"; TRANSMEM 442..462; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3"; TRANSMEM 486..506; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3"; TRANSMEM 550..570; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3
uniprot
proteins