CMTM4
entrez
146223
canonical
uniprot
Q8IZR5
canonical
ensembl
ENSG00000183723
resolver
ensp
ENSP00000333833
resolver
ensp
ENSP00000377666
resolver
ensp
ENSP00000456380
resolver
genesymbol
CMTM4
resolver
genesymbol_syn
CKLFSF4
resolver
hgnc
HGNC:19175
resolver
uniprot
Q52M40
resolver
uniprot
Q8IZR4
resolver
uniprot
Q8IZV1
resolver
uniprot_entry
CKLF4_HUMAN
resolver
uniprot_sec
Q52M40
resolver
uniprot_sec
Q8IZR4
resolver
uniprot_sec
Q8IZV1
resolver
amino_acid_sequence
MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
uniprot
proteins
function
FUNCTION: Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation. {ECO:0000269|PubMed:28813410}.
uniprot
proteins
mass_dalton
25828
uniprot
proteins
protein_family
Chemokine-like factor family
uniprot
proteins
pubmed
12782130
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28813410
uniprot
proteins
sequence_length
234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 59..79; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 85..105; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 123..143; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 151..171; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins