Rasgrp1
entrez
29434
canonical
uniprot
Q9R1K8
canonical
ensembl
ENSRNOG00000005404
resolver
ensp
ENSRNOP00000007687
resolver
genesymbol
Rasgrp1
resolver
genesymbol_syn
Rasgrp
resolver
uniprot
O88469
resolver
uniprot_entry
GRP1_RAT
resolver
uniprot_sec
O88469
resolver
activity_regulation
ACTIVITY REGULATION: Autoinhibited (By similarity). Activated by diacylglycerol and calcium binding, which induces a conformational change releasing the autoinhibitory state (PubMed:9582122). Regulated by DGKA. Regulated by DGKZ. Regulated by PLC gamma and F-actin polymerization (By similarity). {ECO:0000250|UniProtKB:O95267, ECO:0000269|PubMed:9582122}.
uniprot
proteins
amino_acid_sequence
MGTLGKAREAPRKPCHGSRAGPKGRLEAKSTNSPLPAQPSLAQITQFRMMVSLGHLAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIIISSAELLQKLMNLYKDALEKNSPGICLKICYFVRYWITEFWIMFKMDASLTSTMEEFQDLVKANGEESHCHLIDTTQINSRDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLEDGKVNVQKLLALYNHINELVQLQDVAPPLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRSKSPAVSTENISSVVPMSTLCPLGTKDLLHAPEEGSFIFQNGEVVDHSEESKDRTIMLLGVSSQKISVRLKRTVAHKTTQTESFPWVGGEMPPGHFVLTSPRKSAQGALYVHSPASPCPSPALVRKRAFVKWENKESLIKPKPELHLRLRTYQELEQEVNTLRADNDALKIQLKYAQKQIESLQLGKSNHVLAQMDHGDGT
uniprot
proteins
function
FUNCTION: Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:9582122, PubMed:9789079). Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (By similarity). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types. Proto-oncogene, which promotes T-cell lymphomagenesis when its expression is deregulated (By similarity). {ECO:0000250|UniProtKB:O95267, ECO:0000250|UniProtKB:Q9Z1S3, ECO:0000269|PubMed:9582122, ECO:0000269|PubMed:9789079}.
uniprot
proteins
mass_dalton
90245
uniprot
proteins
mutagenesis
MUTAGEN 510..521; /note="DKDREGLISRDE->AKARAGLISRDA: Loss of calcium-binding."; /evidence="ECO:0000269|PubMed:9582122
uniprot
proteins
protein_family
RASGRP family
uniprot
proteins
pubmed
10779365
uniprot
proteins
pubmed
11279364
uniprot
proteins
pubmed
11738253
uniprot
proteins
pubmed
12626538
uniprot
proteins
pubmed
15064353
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9582122
uniprot
proteins
pubmed
9789079
uniprot
proteins
sequence_length
795
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent (By similarity). Translocates to the Golgi in response to phorbol ester or nerve growth factor (By similarity). Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells. {ECO:0000250}.
uniprot
proteins