Nsun2
entrez
28114
canonical
uniprot
Q1HFZ0
canonical
ensembl
ENSMUSG00000021595
resolver
ensp
ENSMUSP00000105321
resolver
genesymbol
Nsun2
resolver
genesymbol_syn
D13Wsu123e
resolver
genesymbol_syn
Misu
resolver
uniprot
A0PJD6
resolver
uniprot
Q3U972
resolver
uniprot
Q8BPG9
resolver
uniprot
Q8CDF9
resolver
uniprot
Q91YX9
resolver
uniprot_entry
NSUN2_MOUSE
resolver
uniprot_sec
A0PJD6
resolver
uniprot_sec
Q3U972
resolver
uniprot_sec
Q8BPG9
resolver
uniprot_sec
Q8CDF9
resolver
uniprot_sec
Q91YX9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by magnesium ions. {ECO:0000250|UniProtKB:Q08J23}.
uniprot
proteins
amino_acid_sequence
MGRRARGRRFQQPPQPEGEEDASDGGRKRGQAGWEGGYPEIVKENKLFEHYYQELKIVPEGEWDQFMESLREPLPATLRITGYKSHAKEILHCLKNKYFKELEDLEVDGQKVEVPQPLSWYPEELAWHTNLSRKILRKSPLLAKFHQFLVSETESGNISRQEAVSMIPPLLLNVEPHHKILDMCAAPGSKTTQLIEMLHADMSVPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLTVDVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPVEDEAVIAALLEKSEGALELADVSAELPGLKWMPGVSQWKVMTRDGQWFADWHEVPQGRHTQIRPTMFPPTDLEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKAPMPWNKRQPKVQNKSAEAREPRVSSHVAATEGNPSDQSELESQMITGAGDSETAHNTENTESNEKKDGVCGPPPSKKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMVSKELRNVLLNNSEKMKVINTGIKVWCRNNSGEEFDCAFRLAQEGIYTLYPFINSRIITVSMEDVKTLLTQENPFFRKLSSEAYSQVKDLAKGSVVLKYEPDSANPDTLQCPIVLCGWRGKASIRTFVPKNERLHYLRMMGLEVLGEKKKEGVILTNENAASPEQPGDEDAKQTAQDPCVPDSVPGCDAAAAEPSR
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.203
uniprot
proteins
function
FUNCTION: RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:22144916, PubMed:23871666, PubMed:31199786). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:22144916, PubMed:22885326, PubMed:23401851, PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:22885326, PubMed:23871666, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587, PubMed:31287866). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (By similarity). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (By similarity). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (By similarity). May act downstream of Myc to regulate epidermal cell growth and proliferation (PubMed:16713953). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q08J23, ECO:0000269|PubMed:16713953, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22144916, ECO:0000269|PubMed:22885326, ECO:0000269|PubMed:23401851, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31287866}.
uniprot
proteins
mass_dalton
85452
uniprot
proteins
mutagenesis
MUTAGEN 271; /note="C->A: Loss of RNA methyltransferase activity."; /evidence="ECO:0000269|PubMed:23871666
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-139 by AURKB during mitosis, leading to abolish methyltransferase activity and the interaction with NPM1. {ECO:0000250|UniProtKB:Q08J23}.
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
RsmB/NOP family
uniprot
proteins
protein_family
TRM4 subfamily
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16713953
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19596847
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22144916
uniprot
proteins
pubmed
22885326
uniprot
proteins
pubmed
23401851
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
23871666
uniprot
proteins
pubmed
28341602
uniprot
proteins
pubmed
31199786
uniprot
proteins
pubmed
31276587
uniprot
proteins
pubmed
31287866
uniprot
proteins
sequence_length
757
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16713953, ECO:0000269|PubMed:19596847}. Cytoplasm {ECO:0000250|UniProtKB:Q08J23}. Mitochondrion {ECO:0000250|UniProtKB:Q08J23}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19596847}. Secreted, extracellular exosome {ECO:0000269|PubMed:28341602}. Note=Concentrated in the nucleolus during interphase and translocates to the spindle during mitosis as an RNA-protein complex that includes 18S ribosomal RNA (PubMed:19596847). In testis, localizes to the chromatoid body (PubMed:23401851). {ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:23401851}.
uniprot
proteins