ARPC5
entrez
10092
canonical
uniprot
O15511
canonical
ensembl
ENSG00000162704
resolver
ensp
ENSP00000294742
resolver
ensp
ENSP00000352918
resolver
genesymbol
ARPC5
resolver
genesymbol_syn
ARC16
resolver
hgnc
HGNC:708
resolver
uniprot
A6NEC4
resolver
uniprot
Q6PG42
resolver
uniprot_entry
ARPC5_HUMAN
resolver
uniprot_sec
A6NEC4
resolver
uniprot_sec
Q6PG42
resolver
amino_acid_sequence
MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLRQGNMTAALQAALKNPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAMLLQWHEKALAAGGVGSIVRVLTARKTV
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 113 with autoimmunity and autoinflammation (IMD113) [MIM:620565]: An autosomal recessive immunologic disorder characterized by recurrent and severe infections, early-onset autoimmunity, inflammation, and facial dysmorphism. Features of autoimmunity and autoinflammation include hemolytic anemia, thrombocytopenia, hepatosplenomegaly, leukocytosis, neutrophilia, and elevated acute phase reactants. {ECO:0000269|PubMed:37349293}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.
uniprot
proteins
mass_dalton
16320
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation. {ECO:0000269|PubMed:22016387}.
uniprot
proteins
protein_family
ARPC5 family
uniprot
proteins
pubmed
11741539
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22016387
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29925947
uniprot
proteins
pubmed
37349293
uniprot
proteins
pubmed
9230079
uniprot
proteins
pubmed
9359840
uniprot
proteins
sequence_length
151
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9230079}. Cell projection {ECO:0000269|PubMed:9230079}. Nucleus {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:37349293}.
uniprot
proteins