Ctss
entrez
13040
canonical
uniprot
O70370
canonical
ensembl
ENSMUSG00000038642
resolver
ensp
ENSMUSP00000015667
resolver
ensp
ENSMUSP00000112006
resolver
enst
ENSMUST00000015667
resolver
enst
ENSMUST00000116304
resolver
genesymbol
Ctss
resolver
genesymbol_syn
Cats
resolver
uniprot
E9QK18
resolver
uniprot
F6WR04
resolver
uniprot
O54973
resolver
uniprot
Q3UD32
resolver
uniprot
Q8BSZ5
resolver
uniprot_entry
CATS_MOUSE
resolver
uniprot_entry
F6WR04_MOUSE
resolver
uniprot_entry
Q3UD32_MOUSE
resolver
uniprot_entry
Q8BSZ5_MOUSE
resolver
uniprot_sec
E9QK18
resolver
uniprot_sec
O54973
resolver
amino_acid_sequence
MRAPGHAAIRWLFWMPLVCSVAMEQLQRDPTLDYHWDLWKKTHEKEYKDKNEEEVRRLIWEKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEILCRMGALRIPRQSPKTVTFRSYSNRTLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSNEEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKATDEKCHYNSKNRAATCSRYIQLPFGDEDALKEAVATKGPVSVGIDASHSSFFFYKSGVYDDPSCTGNVNHGVLVVGYGTLDGKDYWLVKNSWGLNFGDQGYIRMARNNKNHCGIASYCSYPEI
uniprot
proteins
ec_number
3.4.22.27
uniprot
proteins
function
FUNCTION: Thiol protease (PubMed:26216096). Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (By similarity). The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity). Elicits itch by mediating cleavage and activation of MRGPRX1 (PubMed:26216096). {ECO:0000250|UniProtKB:P25774, ECO:0000269|PubMed:26216096}.
uniprot
proteins
mass_dalton
38475
uniprot
proteins
protein_family
Peptidase C1 family
uniprot
proteins
pubmed
10395917
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26216096
uniprot
proteins
pubmed
9516475
uniprot
proteins
pubmed
9545226
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:P25774}. Secreted {ECO:0000250|UniProtKB:P25774}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P25774}.
uniprot
proteins