TXN2
entrez
25828
canonical
uniprot
Q99757
canonical
ensembl
ENSG00000100348
resolver
ensp
ENSP00000216185
resolver
ensp
ENSP00000385393
resolver
ensp
ENSP00000554066
resolver
ensp
ENSP00000554067
resolver
ensp
ENSP00000554068
resolver
ensp
ENSP00000554069
resolver
ensp
ENSP00000600582
resolver
ensp
ENSP00000600584
resolver
ensp
ENSP00000600585
resolver
ensp
ENSP00000611534
resolver
enst
ENST00000216185
resolver
enst
ENST00000403313
resolver
enst
ENST00000884007
resolver
enst
ENST00000884008
resolver
enst
ENST00000884009
resolver
enst
ENST00000884010
resolver
enst
ENST00000930523
resolver
enst
ENST00000930525
resolver
enst
ENST00000930526
resolver
enst
ENST00000941475
resolver
genesymbol
TXN2
resolver
genesymbol_syn
TRX2
resolver
hgnc
HGNC:17772
resolver
uniprot
Q5JZA0
resolver
uniprot
Q6FH60
resolver
uniprot
Q9UH29
resolver
uniprot_entry
THIOM_HUMAN
resolver
uniprot_sec
Q5JZA0
resolver
uniprot_sec
Q6FH60
resolver
uniprot_sec
Q9UH29
resolver
amino_acid_sequence
MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG
uniprot
proteins
disease_involvement
DISEASE: Combined oxidative phosphorylation deficiency 29 (COXPD29) [MIM:616811]: An autosomal recessive, infantile-onset, neurodegenerative disorder characterized by decreased activities of mitochondrial respiratory complexes I and III, severe cerebellar atrophy, epilepsy, dystonia, optic atrophy, and peripheral neuropathy. {ECO:0000269|PubMed:26626369}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability (PubMed:12032145, PubMed:12080052, PubMed:26626369) Is involved in various redox reactions including the reduction of protein disulfide bonds, through the reversible oxidation of its active center dithiol to a disulfide (By similarity). {ECO:0000250|UniProtKB:P97615, ECO:0000269|PubMed:12032145, ECO:0000269|PubMed:12080052, ECO:0000269|PubMed:26626369}.
uniprot
proteins
mass_dalton
18383
uniprot
proteins
protein_family
Thioredoxin family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12032145
uniprot
proteins
pubmed
12080052
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16195549
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19892738
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26626369
uniprot
proteins
sequence_length
166
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12032145, ECO:0000269|PubMed:12080052}.
uniprot
proteins