MCUB
entrez
55013
canonical
uniprot
Q9NWR8
canonical
ensembl
ENSG00000005059
resolver
ensp
ENSP00000378145
resolver
enst
ENST00000394650
resolver
genesymbol
MCUB
resolver
genesymbol_syn
CCDC109B
resolver
hgnc
HGNC:26076
resolver
uniprot
A8K4Y3
resolver
uniprot
Q6IAC1
resolver
uniprot_entry
MCUB_HUMAN
resolver
uniprot_sec
A8K4Y3
resolver
uniprot_sec
Q6IAC1
resolver
amino_acid_sequence
MLQRGLWPWRTRLLPTPGTWRPARPWPLPPPPQVLRVKLCGNVKYYQSHHYSTVVPPDEITVIYRHGLPLVTLTLPSRKERCQFVVKPMLSTVGSFLQDLQNEDKGIKTAAIFTADGNMISASTLMDILLMNDFKLVINKIAYDVQCPKREKPSNEHTAEMEHMKSLVHRLFTILHLEESQKKREHHLLEKIDHLKEQLQPLEQVKAGIEAHSEAKTSGLLWAGLALLSIQGGALAWLTWWVYSWDIMEPVTYFITFANSMVFFAYFIVTRQDYTYSAVKSRQFLQFFHKKSKQQHFDVQQYNKLKEDLAKAKESLKQARHSLCLQMQVEELNEKN
uniprot
proteins
function
FUNCTION: Negative regulator of the mitochondrial calcium uniporter (MCU), a channel that mediates calcium uptake into the mitochondrial matrix (PubMed:31533452). MCUB is required to limit mitochondrial calcium overload during stress (PubMed:31533452). Acts as a dominant-negative regulator that displaces MCU from the functional uniplex complex and thereby decreases the association of calcium sensors MICU1 and MICU2, preventing channel gating (PubMed:31533452). Mitochondrial calcium homeostasis plays key roles in mitochondrial metabolism (PubMed:31533452). Acts as an important regulator of mitochondrial metabolism in response to stress in muscle cells: induced in response to fasting, leading to restrict mitochondrial calcium uptake, resulting in reprogramming of mitochondria toward fatty acid oxidation preference (By similarity). Acts as a regulator of macrophage polarization during skeletal muscle regeneration: inhibition of mitochondrial calcium uptake drives differentiation of macrophages with anti-inflammatory profile, promoting the differentiation and fusion of satellite cells (By similarity). {ECO:0000250|UniProtKB:Q810S1, ECO:0000269|PubMed:31533452}.
uniprot
proteins
mass_dalton
39082
uniprot
proteins
protein_family
MCU (TC 1.A.77) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24231807
uniprot
proteins
pubmed
31533452
uniprot
proteins
sequence_length
336
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:24231807}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 220..240; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 250..270; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins