SLC36A1
entrez
206358
canonical
uniprot
Q7Z2H8
canonical
ensembl
ENSG00000123643
resolver
ensp
ENSP00000243389
resolver
ensp
ENSP00000395640
resolver
ensp
ENSP00000428140
resolver
ensp
ENSP00000430305
resolver
ensp
ENSP00000552884
resolver
ensp
ENSP00000552885
resolver
ensp
ENSP00000552886
resolver
ensp
ENSP00000552887
resolver
ensp
ENSP00000552888
resolver
ensp
ENSP00000552889
resolver
ensp
ENSP00000552890
resolver
ensp
ENSP00000594401
resolver
ensp
ENSP00000793904
resolver
ensp
ENSP00000793906
resolver
genesymbol
SLC36A1
resolver
genesymbol_syn
PAT1
resolver
hgnc
HGNC:18761
resolver
uniprot
C9JI34
resolver
uniprot
Q1LZ56
resolver
uniprot
Q7Z7C0
resolver
uniprot
Q86YK4
resolver
uniprot
Q96M74
resolver
uniprot_entry
S36A1_HUMAN
resolver
uniprot_sec
C9JI34
resolver
uniprot_sec
Q1LZ56
resolver
uniprot_sec
Q7Z7C0
resolver
uniprot_sec
Q86YK4
resolver
uniprot_sec
Q96M74
resolver
amino_acid_sequence
MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDYGDTVMYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNCHNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVTILYISLGCLGYLQFGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIPFFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIFINSTCAFI
uniprot
proteins
function
FUNCTION: Electrogenic proton/amino acid symporter with selectivity for small apolar L-amino acids, their D-enantiomers and selected amino acid derivatives such as 4-aminobutanoate/GABA (PubMed:12527723, PubMed:12809675, PubMed:19549785). May be involved in the efflux from the lysosomal compartment of neutral amino acids resulting from proteolysis (By similarity). May play a role in specifying sites for exocytosis in neurons (By similarity). {ECO:0000250|UniProtKB:Q924A5, ECO:0000269|PubMed:12527723, ECO:0000269|PubMed:12809675, ECO:0000269|PubMed:19549785}.
uniprot
proteins
mass_dalton
53076
uniprot
proteins
mutagenesis
MUTAGEN 180; /note="C->A,S: Loss amino acid:proton symporter activity. No effect on localization to the plasma membrane."; /evidence="ECO:0000269|PubMed:19549785"; MUTAGEN 329; /note="C->A,S: Loss amino acid:proton symporter activity. No effect on localization to the plasma membrane."; /evidence="ECO:0000269|PubMed:19549785"; MUTAGEN 473; /note="C->A,S: No effect on amino acid:proton symporter activity. No effect on localization to the plasma membrane."; /evidence="ECO:0000269|PubMed:19549785
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
pubmed
12527723
uniprot
proteins
pubmed
12809675
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15058382
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17897319
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19549785
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12527723, ECO:0000269|PubMed:12809675, ECO:0000269|PubMed:19549785}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:12527723}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000255}. Note=In neurons, colocalizes with the exocyst complex in the axonal processes. {ECO:0000250|UniProtKB:Q924A5}.
uniprot
proteins
transmembrane_region
TRANSMEM 52..72; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 191..211; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 216..236; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 290..310; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 343..363; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 373..393; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 398..418; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 440..460; /note="Helical; Name=11"; /evidence="ECO:0000255
uniprot
proteins