CD69
entrez
969
canonical
uniprot
Q07108
canonical
ensembl
ENSG00000110848
resolver
ensp
ENSP00000228434
resolver
enst
ENST00000228434
resolver
genesymbol
CD69
resolver
genesymbol_syn
CLEC2C
resolver
hgnc
HGNC:1694
resolver
uniprot
Q53ZX0
resolver
uniprot_entry
CD69_HUMAN
resolver
uniprot_entry
Q53ZX0_HUMAN
resolver
amino_acid_sequence
MSSENCFVAENSSLHPESGQENDATSPHFSTRHEGSFQVPVLCAVMNVVFITILIIALIALSVGQYNCPGQYTFSMPSDSHVSSCSEDWVGYQRKCYFISTVKRSWTSAQNACSEHGATLAVIDSEKDMNFLKRYAGREEHWVGLKKEPGHPWKWSNGKEFNNWFNVTGSDKCVFLKNTEVSSMECEKNLYWICNKPYK
uniprot
proteins
function
FUNCTION: Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types (PubMed:24752896, PubMed:26296369, PubMed:35930205). Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells (PubMed:24752896). Association of CD69 cytoplasmic tail with the JAK3/STAT5 signaling pathway regulates the transcription of RORgamma/RORC and, consequently, differentiation toward the Th17 lineage (By similarity). Also acts via the S100A8/S100A9 complex present on peripheral blood mononuclear cells to promote the conversion of naive CD4 T-cells into regulatory T-cells (PubMed:26296369). Acts as an oxidized low-density lipoprotein (oxLDL) receptor in CD4 T-lymphocytes and negatively regulates the inflammatory response by inducing the expression of PDCD1 through the activation of NFAT (PubMed:35930205). Participates in adipose tissue-derived mesenchymal stem cells (ASCs)-mediated protection against P.aeruginosa infection. Mechanistically, specifically recognizes P.aeruginosa to promote ERK1 activation, followed by granulocyte-macrophage colony-stimulating factor (GM-CSF) and other inflammatory cytokines secretion (PubMed:34841721). In eosinophils, induces IL-10 production through the ERK1/2 pathway (By similarity). Negatively regulates the chemotactic responses of effector lymphocytes and dendritic cells (DCs) to sphingosine 1 phosphate/S1P by acting as a S1PR1 receptor agonist and facilitating the internalization and degradation of the receptor (PubMed:37039481). {ECO:0000250|UniProtKB:P37217, ECO:0000269|PubMed:24752896, ECO:0000269|PubMed:26296369, ECO:0000269|PubMed:34841721, ECO:0000269|PubMed:35930205, ECO:0000269|PubMed:37039481}.
uniprot
proteins
mass_dalton
22559
uniprot
proteins
post_translational_modification
PTM: Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes.
uniprot
proteins
pubmed
11036086
uniprot
proteins
pubmed
11101293
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18959746
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24752896
uniprot
proteins
pubmed
26296369
uniprot
proteins
pubmed
34841721
uniprot
proteins
pubmed
35930205
uniprot
proteins
pubmed
37039481
uniprot
proteins
pubmed
8026529
uniprot
proteins
pubmed
8100776
uniprot
proteins
pubmed
8340758
uniprot
proteins
pubmed
8496594
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37039481}; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 41..61; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins