CALR
entrez
811
canonical
uniprot
P27797
canonical
ensembl
ENSG00000179218
resolver
ensp
ENSP00000320866
resolver
ensp
ENSP00000466037
resolver
enst
ENST00000316448
resolver
enst
ENST00000586967
resolver
genesymbol
CALR
resolver
genesymbol
HEL-S-99n
resolver
genesymbol_syn
CRTC
resolver
hgnc
HGNC:1455
resolver
uniprot
Q6IAT4
resolver
uniprot
Q9UDG2
resolver
uniprot
V9HW88
resolver
uniprot_entry
CALR_HUMAN
resolver
uniprot_entry
V9HW88_HUMAN
resolver
uniprot_sec
Q6IAT4
resolver
uniprot_sec
Q9UDG2
resolver
amino_acid_sequence
MLLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDEEKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDEDKDEDEEDEEDKEEDEEEDVPGQAKDEL
uniprot
proteins
disease_involvement
DISEASE: Note=CALR somatic mutations are frequently found in myeloproliferative neoplasms lacking JAK2 or MPL mutations. Myeloproliferative neoplasms are chronic myeloid cancers characterized by overproduction of mature blood cells, and may evolve into acute myeloid leukemia. In addition to chronic myeloid leukemia with the BCR-ABL fusion gene, the three most common myeloproliferative neoplasms are essential thrombocythemia, polycythemia vera, and myelofibrosis. {ECO:0000269|PubMed:24325356, ECO:0000269|PubMed:24325359}.
uniprot
proteins
function
FUNCTION: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}.
uniprot
proteins
mass_dalton
48142
uniprot
proteins
protein_family
Calreticulin family
uniprot
proteins
pubmed
10358038
uniprot
proteins
pubmed
10605026
uniprot
proteins
pubmed
11149926
uniprot
proteins
pubmed
11322874
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
1286669
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1733953
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
1911778
uniprot
proteins
pubmed
19154346
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
1919005
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20801878
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21423620
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
2332496
uniprot
proteins
pubmed
23614004
uniprot
proteins
pubmed
2400400
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24325356
uniprot
proteins
pubmed
24325359
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27840680
uniprot
proteins
pubmed
29192674
uniprot
proteins
pubmed
30157172
uniprot
proteins
pubmed
3260607
uniprot
proteins
pubmed
7841019
uniprot
proteins
pubmed
7876246
uniprot
proteins
pubmed
8418194
uniprot
proteins
pubmed
8666824
uniprot
proteins
pubmed
9150948
uniprot
proteins
pubmed
9427624
uniprot
proteins
pubmed
9640257
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:10358038, ECO:0000269|PubMed:11149926}. Cytoplasm, cytosol {ECO:0000269|PubMed:11149926}. Secreted, extracellular space, extracellular matrix {ECO:0000305}. Cell surface {ECO:0000269|PubMed:10358038}. Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P28491}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8K3H7}. Cytolytic granule {ECO:0000269|PubMed:8418194}. Note=Also found in cell surface (T cells), cytosol and extracellular matrix (PubMed:10358038). During oocyte maturation and after parthenogenetic activation accumulates in cortical granules. In pronuclear and early cleaved embryos localizes weakly to cytoplasm around nucleus and more strongly in the region near the cortex (By similarity). In cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:8418194}.
uniprot
proteins