Dyrk1b
entrez
13549
canonical
uniprot
Q9Z188
canonical
ensembl
ENSMUSG00000002409
resolver
ensp
ENSMUSP00000083064
resolver
ensp
ENSMUSP00000133431
resolver
ensp
ENSMUSP00000133719
resolver
genesymbol
Dyrk1b
resolver
uniprot
Q3UFR5
resolver
uniprot
Q70UR5
resolver
uniprot
Q9EPM2
resolver
uniprot_entry
DYR1B_MOUSE
resolver
uniprot_sec
Q3UFR5
resolver
uniprot_sec
Q70UR5
resolver
uniprot_sec
Q9EPM2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by RANBP9. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDAASAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSTKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSNDNRAYRYSNRYCGGPGPPITDCEMNSPQVLPSQPLRPWAGGDVPHKTHQAPISASTLPGTGAQLPPLPRCLGRPPSPTSPPPPELMDVSLVGSPPDCSPPPPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPRLGLHGVPQSTAASS
uniprot
proteins
ec_number
2.7.12.1
uniprot
proteins
function
FUNCTION: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:12633499). Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance. During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1). {ECO:0000250|UniProtKB:Q9Y463, ECO:0000269|PubMed:12633499}.
uniprot
proteins
mass_dalton
69178
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MNB/DYRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
12633499
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9918863
uniprot
proteins
sequence_length
629
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y463}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9Y463}. Chromosome {ECO:0000250|UniProtKB:Q9Y463}. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. {ECO:0000250|UniProtKB:Q9Y463}.
uniprot
proteins