Lrrc23
entrez
16977
canonical
uniprot
O35125
canonical
ensembl
ENSMUSG00000030125
resolver
ensp
ENSMUSP00000032218
resolver
ensp
ENSMUSP00000108094
resolver
ensp
ENSMUSP00000218817
resolver
ensp
ENSMUSP00000218818
resolver
ensp
ENSMUSP00000362512
resolver
enst
ENSMUST00000032218
resolver
enst
ENSMUST00000112475
resolver
genesymbol
Lrrc23
resolver
genesymbol_syn
Lrpb7
resolver
uniprot_entry
LRC23_MOUSE
resolver
amino_acid_sequence
MSDEDDVDDVDAEQDEVESDKEIEEWEDYRKETEEASEEWLPTPITEAMMKEGLSLLCKIGSGLAHAYIKLEAKDRDLTDISLLRSYIHLRYVDISENHITDISPLNSLTHLLWLKADGNQLRSARMNELPYLQIASFSYNQIIDTEGIFHPRLGSLDLKGNRIHQVTGLDPERLSSLHTLELRGNQLESTKGIYLPKLKNLYLAQNLLKKVEGLENLSNLTTLHLRDNQIETLNGFSQEMKSLQYLNLRSNMISDLAELAKLRDLPKLRALVLLDNPCADETDYRQEALVQMAHLERLDKEFYEDDDRAEAEEIRQRLKEEQDQDLDPDQDMEPYLPPV
uniprot
proteins
function
FUNCTION: Essential for sperm motility and male fertility. Plays an important role in the proper assembly of the third radial spoke (RS3) head and the bridge structure between RS2 and RS3 in the sperm flagella. {ECO:0000269|PubMed:34585727, ECO:0000269|PubMed:38091523}.
uniprot
proteins
mass_dalton
39292
uniprot
proteins
mutagenesis
MUTAGEN 205..340; /note="AQNLLKKVEGLENLSNLTTLHLRDNQIETLNGFSQEMKSLQYLNLRSNMISDLAELAKLRDLPKLRALVLLDNPCADETDYRQEALVQMAHLERLDKEFYEDDDRAEAEEIRQRLKEEQDQDLDPDQDMEPYLPPV->VAHRALRWHREGGTAGNHGGDKASHGT: Mice show defective sperm motility and male infertility. Impaired protein localization to sperm flagellum and disruption of the assembly of the third radial spoke head seen in the sperm flagellum."; /evidence="ECO:0000269|PubMed:38091523
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34585727
uniprot
proteins
pubmed
38091523
uniprot
proteins
pubmed
9445485
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:34585727, ECO:0000269|PubMed:38091523}. Cytoplasm {ECO:0000250|UniProtKB:Q53EV4}. Note=Within the sperm flagellum, may be associated with the head of radial spoke 3. {ECO:0000305|PubMed:38091523}.
uniprot
proteins