Trmt112
entrez
67674
canonical
uniprot
Q9DCG9
canonical
ensembl
ENSMUSG00000038812
resolver
ensp
ENSMUSP00000085591
resolver
ensp
ENSMUSP00000112250
resolver
enst
ENSMUST00000088257
resolver
enst
ENSMUST00000116551
resolver
genesymbol
Trmt112
resolver
genesymbol_syn
0610038D11Rik
resolver
uniprot
Q5M8M3
resolver
uniprot
Q91YP8
resolver
uniprot
Q9D1N6
resolver
uniprot_entry
Q5M8M3_MOUSE
resolver
uniprot_entry
TR112_MOUSE
resolver
uniprot_sec
Q91YP8
resolver
uniprot_sec
Q9D1N6
resolver
amino_acid_sequence
MKLLTHNLLSSHVRGVGTRGFPLRLQATEVRINPVEFNPEFVARMIPKVEWAALVQAADTLNLAEVPKEPTEGYEHDETFLRKMHHVLLEVDVLEGTLQCPESGRLFPISRGIPNMLLNDEETET
uniprot
proteins
function
FUNCTION: Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:20606008, PubMed:26797129). Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA (By similarity). The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:20606008, PubMed:26797129). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (By similarity). Together with methyltransferase THUMPD3, catalyzes the formation of N(2)-methylguanosine at position 6 in a broad range of tRNA substrates and at position 7 of tRNA(Trp) (By similarity). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (By similarity). Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (By similarity). {ECO:0000250|UniProtKB:Q9UI30, ECO:0000269|PubMed:20606008, ECO:0000269|PubMed:26797129}.
uniprot
proteins
mass_dalton
14141
uniprot
proteins
protein_family
TRM112 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20606008
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26797129
uniprot
proteins
pubmed
34669960
uniprot
proteins
sequence_length
125
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9UI30}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9UI30}. Note=Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes. {ECO:0000250|UniProtKB:Q9UI30}.
uniprot
proteins