IBSP
entrez
3381
canonical
uniprot
P21815
canonical
ensembl
ENSG00000029559
resolver
ensp
ENSP00000226284
resolver
ensp
ENSP00000553306
resolver
enst
ENST00000226284
resolver
enst
ENST00000883247
resolver
genesymbol
IBSP
resolver
genesymbol_syn
BNSP
resolver
hgnc
HGNC:5341
resolver
uniprot_entry
SIAL_HUMAN
resolver
amino_acid_sequence
MKTALILLSILGMACAFSMKNLHRRVKIEDSEENGVFKYRPRYYLYKHAYFYPHLKRFPVQGSSDSSEENGDDSSEEEEEEEETSNEGENNEESNEDEDSEAENTTLSATTLGYGEDATPGTGYTGLAAIQLPKKAGDITNKATKEKESDEEEEEEEEGNENEESEAEVDENEQGINGTSTNSTEAENGNGSSGGDNGEEGEEESVTGANAEDTTETGRQGKGTSKTTTSPNGGFEPTTPPQVYRTTSPPFGKTTTVEYEGEYEYTGANEYDNGYEIYESENGEPRGDNYRAYEDEYSYFKGQGYDGYDGQNYYHHQ
uniprot
proteins
function
FUNCTION: Binds tightly to hydroxyapatite (PubMed:11459848). Appears to form an integral part of the mineralized matrix (PubMed:1818768). Probably important to cell-matrix interaction (PubMed:1818768). Promotes adhesion and migration of various cells via the alpha-V/beta-3 integrin receptor (ITGAV:ITGB3) (PubMed:10640428, PubMed:11459848, PubMed:24103036). {ECO:0000269|PubMed:10640428, ECO:0000269|PubMed:11459848, ECO:0000269|PubMed:1818768, ECO:0000269|PubMed:24103036}.
uniprot
proteins
mass_dalton
35148
uniprot
proteins
mutagenesis
MUTAGEN 286..288; /note="RGD->KAE: Significantly reduces cell attachment activity."; /evidence="ECO:0000269|PubMed:24103036"; MUTAGEN 288; /note="D->E: Modestly reduces cell attachment activity."; /evidence="ECO:0000269|PubMed:24103036
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains. {ECO:0000269|PubMed:11459848}.; PTM: O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc. {ECO:0000269|PubMed:11459848}.
uniprot
proteins
pubmed
10640428
uniprot
proteins
pubmed
11459848
uniprot
proteins
pubmed
11669636
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
1818768
uniprot
proteins
pubmed
2404984
uniprot
proteins
pubmed
24103036
uniprot
proteins
pubmed
3597437
uniprot
proteins
pubmed
36261010
uniprot
proteins
pubmed
8061918
uniprot
proteins
pubmed
8406493
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11459848}.
uniprot
proteins