Q9JJS5
uniprot
Q9JJS5
canonical
amino_acid_sequence
MAAQRIRAANSSGLPRCKSEGTLIDLSEGFSETSFNDVKVPSPSALLVDNPTPFGNAKEVIAIKDYCPNNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLSDSGMIDNLPDSPDEVAKELDLLGGWTDDQKQSGRPYSNNPFWNGVRTNPFLNGNAQPSMDELNPKSTVDLLLFDTGTSSFTESSSATTNSTGNIFDELPATNGIHLEQPVKRDNPFFRSKRSYSLSELSVLQAKSDAPPTSSFFTGLKSPAPEQFQSREDFRTAWLNHRKLARSCHDLDLLGQSPGWGQTQAVETNIVCKLDSSGGSVQLPDTSISIHVPEGHVAPGETQQISMKALLDPPLDLNSDRSTSISPVVEVKLSNLEVSTFIILEMKVSAEVKGDIFSKSTVVLQCLRSDSKEGPYAPIPLAYSYGDTIQVQLDNLEPCMYLAIVAQGSNILYPSTVWDFIHKRVTVGLYGPKHIHPSFKTVVTIFGHDCAPKTLLVTEVTRQAPSPAPVALQLWGKHQFILSRPQDLRVCMFSNMTNYDVKSNEQAKVVRGFQMKLGKVSRLIFSVISQNPNELSDFTLRVQVKDDQDTILTQFCVQTPQPPPKSAIKPSGQRRFLKKNEVGKIILSPFVVTTKYPTFQDRPVSSLKFGKLLKTVVRQNKSHYLLEYKKGDVVALLSEERIRLKGQLWTKEWYIGYYQGKVGLVHTKNVLVVGKARPSLFSGPELSTSVLLEQILRPCKFLTYIYASVRTLLMENISSWRAFADALGYGNLPLTFFCRAELDSEPERVASVLEKLKEDCNNPDNKDRKSFQKELVMALLKMDCQGLVVRLIQDFVLLTTAVEVAQRWRELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLLTWSHQIGDSYRDVIQELHIGLDKMKNPITRRWKHLTGTLILVNSLDILRAAAFSPADHDDFVI
uniprot
proteins
function
FUNCTION: May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
107513
uniprot
proteins
post_translational_modification
PTM: Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2 (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
961
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane, clathrin-coated pit {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}. Nucleus {ECO:0000250}. Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus (By similarity). {ECO:0000250}.
uniprot
proteins