Mrgpre
entrez
404660
canonical
uniprot
Q7TN40
canonical
ensembl
ENSRNOG00000065330
resolver
ensembl
ENSRNOG00055018800
resolver
ensembl
ENSRNOG00060025525
resolver
ensembl
ENSRNOG00065033403
resolver
ensp
ENSRNOP00000079771
resolver
ensp
ENSRNOP00000089804
resolver
ensp
ENSRNOP00000093679
resolver
ensp
ENSRNOP00000104288
resolver
ensp
ENSRNOP00000106586
resolver
ensp
ENSRNOP00055025904
resolver
ensp
ENSRNOP00055025906
resolver
ensp
ENSRNOP00055025911
resolver
ensp
ENSRNOP00055025916
resolver
ensp
ENSRNOP00060036621
resolver
ensp
ENSRNOP00060036636
resolver
ensp
ENSRNOP00060036642
resolver
ensp
ENSRNOP00060036656
resolver
ensp
ENSRNOP00065047262
resolver
ensp
ENSRNOP00065047264
resolver
ensp
ENSRNOP00065047266
resolver
enst
ENSRNOT00000094719
resolver
enst
ENSRNOT00000109796
resolver
enst
ENSRNOT00000115771
resolver
enst
ENSRNOT00000167139
resolver
enst
ENSRNOT00000167734
resolver
enst
ENSRNOT00055032034
resolver
enst
ENSRNOT00055032038
resolver
enst
ENSRNOT00055032045
resolver
enst
ENSRNOT00055032052
resolver
enst
ENSRNOT00060044152
resolver
enst
ENSRNOT00060044173
resolver
enst
ENSRNOT00060044181
resolver
enst
ENSRNOT00060044201
resolver
enst
ENSRNOT00065057421
resolver
enst
ENSRNOT00065057423
resolver
enst
ENSRNOT00065057425
resolver
genesymbol
Mrgpre
resolver
genesymbol_syn
Mrge
resolver
uniprot_entry
MRGRE_RAT
resolver
amino_acid_sequence
MSLRVHTHSPSTQGDMAFNLTILSLTELLSLGGLLGNGVALWLLNQNVYRNPFSIYLLDVACADLIFLCCHMVAIIPELLQDQLNFPEFVHISLIMLRFFCYIVGLSLLVAISTEQCLATLFPSGYLCRRPRYLTTCVCAFIWVLCLLLDLLLSGACTQFFGAPSYHLCGMLWLVVAVLLAALCCTMCVTSLLLLLRVERGPERHQPRGFPTLVLLVILLFLFCGLPFGIFWLSKNLSWHTPLYFYHFSFFMASVHSAAKPAIYFFLGSTPGQRFQEPLRLVLQRALGDEAELGAVREASQGGLVDMTV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for L-tryptophanocholate (Trp-CA), an amino-acid-conjugated bile acid produced by the microbiome, which regulates glucose homeostasis. Expressed in enteroendocrine L cells of the gut epithelium: Trp-CA binding causes a conformation change that triggers signaling via G(s) G protein, mediating activation of adenylate cyclase activity. In addition to G(s), MRGPRE also associates with beta-arrestin-1 (ARRB1), promoting phosphorylation of ALDOA. Both G(s) and beta-arrestin-1 signaling pathways improves glucose tolerance by enhancing GLP-1 secretion. {ECO:0000250|UniProtKB:Q86SM8}.
uniprot
proteins
mass_dalton
34511
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Mas subfamily
uniprot
proteins
pubmed
12909716
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86SM8}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 60..80; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 133..153; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 169..189; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 248..268; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins