Rap1gds1
entrez
229877
canonical
uniprot
E9Q912
canonical
ensembl
ENSMUSG00000028149
resolver
ensp
ENSMUSP00000029796
resolver
ensp
ENSMUSP00000096173
resolver
ensp
ENSMUSP00000143181
resolver
ensp
ENSMUSP00000294248
resolver
ensp
ENSMUSP00000294262
resolver
ensp
ENSMUSP00000294268
resolver
ensp
ENSMUSP00000294284
resolver
ensp
ENSMUSP00000294286
resolver
ensp
ENSMUSP00000294287
resolver
ensp
ENSMUSP00000294301
resolver
genesymbol
Rap1gds1
resolver
uniprot
E9Q6Q4
resolver
uniprot
I6L967
resolver
uniprot
Q3TA69
resolver
uniprot
Q3TLU4
resolver
uniprot
Q3TPS9
resolver
uniprot
Q3TU36
resolver
uniprot_entry
GDS1_MOUSE
resolver
uniprot_sec
E9Q6Q4
resolver
uniprot_sec
I6L967
resolver
uniprot_sec
Q3TA69
resolver
uniprot_sec
Q3TLU4
resolver
uniprot_sec
Q3TPS9
resolver
uniprot_sec
Q3TU36
resolver
amino_acid_sequence
MDNLSDTLKKLKITAADRTEGSLEGCLDCLLQALAQNNAETSEKIQGSGILQLFANLLTPQASCTAKVADIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCGRTDPASEKLMTVFCGMLMNYSNENDSLQAQLISMGVIPTLVKLLGIHCHNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSNKEDDVAELKTASDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDGNCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVVNKAKMLSAGVTETVLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQLGKNAKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGPAEKDLASAQLVQILHRLLADERSAPEIKYNSMVLICALMGSESLYKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQRLTVES
uniprot
proteins
function
FUNCTION: Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP. Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity. Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS. Regulates mitochondrial dynamics by controlling RHOT function to promote mitochondrial fission during high calcium conditions. Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake. {ECO:0000250|UniProtKB:P52306}.; FUNCTION: [Isoform 1]: Acts as a GEF (guanine nucleotide exchange factor) for unprenylated RHOA. Chaperones the entry and passage of small GTPases through the prenylation pathway. Recognizes the last amino acid in the GTPase C-terminal CAAX motif with a preference for 'Leu' over 'Met', indicating involvement in the geranylgeranylation pathway. May also recognize prenylated GTPases. {ECO:0000250|UniProtKB:P52306}.; FUNCTION: [Isoform 3]: Acts as a GEF (guanine nucleotide exchange factor) for prenylated RHOA. Acts as a GEF for RHOC. Chaperones the downstream trafficking and/or processing of small newly prenylated GTPases. Escorts RAC1 to the nucleus. {ECO:0000250|UniProtKB:P52306}.
uniprot
proteins
mass_dalton
66076
uniprot
proteins
post_translational_modification
PTM: Serotonylated on Gln residues by TGM2 in response to hypoxia, leading to its inactivation. {ECO:0000250|UniProtKB:O55143}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
607
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P52306}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P52306}. Mitochondrion {ECO:0000250|UniProtKB:P52306}. Nucleus {ECO:0000250|UniProtKB:P52306}. Note=Nuclear import is dependent on complexing with a GTPase containing a C-terminal polybasic region. {ECO:0000250|UniProtKB:P52306}.
uniprot
proteins