Or5v1
entrez
258325
canonical
uniprot
A2RT31
canonical
ensembl
ENSMUSG00000090894
resolver
ensp
ENSMUSP00000131089
resolver
ensp
ENSMUSP00000149213
resolver
enst
ENSMUST00000168318
resolver
enst
ENSMUST00000216472
resolver
genesymbol
Or5v1
resolver
genesymbol_syn
Olfr110
resolver
uniprot
A0A1L1SQW5
resolver
uniprot_entry
A0A1L1SQW5_MOUSE
resolver
uniprot_entry
A2RT31_MOUSE
resolver
amino_acid_sequence
MEGKNQTAPSEFIILGFDHLNELQYLLFTIFFLTYICTLGGNVFIIVVTIADSHLHTPMYYFLGNLALIDICYTTTNVPQMMVHLLSEKKIISYGGCVTQLFAFIFFVGSECLLLAAMAYDRYIAICKPLRYSFIMNKALCSWLAASCWTGGFLNSVLHTVLTFHLPFCGNNQINYFFCDIPPLLILSCGDTSLNELALLSIGILIGWTPFLCVILSYLYIISTILRIRSSEGRHKAFSTCASHLLIVILYYGSAIFTYVRPISSYSLEKDRLISVLYSVVTPMLNPVIYTLRNKDIKEAVKAIGRKWQPPVFSSDI
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that acts both as an odorant receptor, and as a classical G protein-coupled receptor outside the olfactory epithelium (PubMed:41570820, PubMed:41570821). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL/G(olf) or GNAS/G(s)) (PubMed:41570820, PubMed:41570821). In olfactory epithelium, activation by methyl (9R,10E,12E)-9-methoxyoctadeca-10,12-dienoate, a plant odorant isolated from E.fortunei Turcz, promotes coupling to GNAL/G(olf), mediating activation of adenylate cyclase activity and increased production of cAMP, initiating a neuronal response that triggers the perception of a smell (PubMed:41570821). Beyond its role in olfaction, also acts as a regulator of glucose metabolism (PubMed:41570820). In liver, activation by oxylipin 12(S)-hydroxyeicosapentaenoate (12(S)-HEPE), initiates a signaling that enhances hepatic fatty acid oxidation via PKA-dependent activation of the transcription factor ATF2, which promotes expression of carnitine palmitoyltransferase CPT1A (PubMed:41570820). Outside of the olfactory system, in tissues lacking GNAL/G(olf), couples to GNAS/G(s), promoting activation of adenylate cyclase activity and production of cAMP (PubMed:41570820). {ECO:0000269|PubMed:41570820, ECO:0000269|PubMed:41570821}.
uniprot
proteins
mass_dalton
35760
uniprot
proteins
mutagenesis
MUTAGEN 17; /note="F->A: Decreased activation by 12(S)-HEPE."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 73; /note="Y->A: Decreased activation by 12(S)-HEPE."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 80; /note="Q->A,L,V: Strongly decreased activation by methyl (9R,10E,12E)-9-methoxyoctadeca-10,12-dienoate."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 80; /note="Q->A: Decreased activation by 12(S)-HEPE."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 84; /note="H->A,L,V: Strongly decreased activation by methyl (9R,10E,12E)-9-methoxyoctadeca-10,12-dienoate."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 84; /note="H->A: Decreased activation by 12(S)-HEPE."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 100; /note="Q->A,L,V: Strongly decreased activation by methyl (9R,10E,12E)-9-methoxyoctadeca-10,12-dienoate."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 100; /note="Q->A: Decreased activation by 12(S)-HEPE."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 101; /note="L->A: Decreased activation by 12(S)-HEPE."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 102; /note="F->A: Decreased activation by 12(S)-HEPE."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 102; /note="F->L: Strongly decreased activation by methyl (9R,10E,12E)-9-methoxyoctadeca-10,12-dienoate."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 104; /note="F->A: Decreased activation by 12(S)-HEPE."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 104; /note="F->L: Strongly decreased activation by methyl (9R,10E,12E)-9-methoxyoctadeca-10,12-dienoate."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 105; /note="I->A: Decreased activation by 12(S)-HEPE."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 108; /note="V->A: Decreased activation by 12(S)-HEPE."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 271; /note="D->A: Decreased activation by 12(S)-HEPE."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 272; /note="R->A,L,V: Strongly decreased activation by methyl (9R,10E,12E)-9-methoxyoctadeca-10,12-dienoate."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 272; /note="R->A: Decreased activation by 12(S)-HEPE."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 278; /note="Y->A: Decreased activation by 12(S)-HEPE."; /evidence="ECO:0000269|PubMed:41570821"; MUTAGEN 278; /note="Y->L: Strongly decreased activation by methyl (9R,10E,12E)-9-methoxyoctadeca-10,12-dienoate."; /evidence="ECO:0000269|PubMed:41570821
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14506126
uniprot
proteins
pubmed
14611657
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
41570820
uniprot
proteins
pubmed
41570821
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:41570820}; Multi-pass membrane protein {ECO:0000269|PubMed:41570821}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 55..75; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 98..118; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 237..257; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 272..292; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins