Prr5
entrez
315189
canonical
uniprot
Q5FVG6
canonical
ensembl
ENSRNOG00000076724
resolver
ensp
ENSRNOP00000112692
resolver
enst
ENSRNOT00000151946
resolver
genesymbol
Prr5
resolver
genesymbol_syn
Protor1
resolver
uniprot
A0ABK0LNU9
resolver
uniprot_entry
A0ABK0LNU9_RAT
resolver
uniprot_entry
PRR5_RAT
resolver
amino_acid_sequence
MRTLRRLKFMSSPSLSDLGKREPGAAGADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFILNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPTLQAIFYPVQGKEPSVRQLALLHFRNTITLSVKLEDALARSHACVPPAIAQMLLVLQGVHESRGVTEDYLRLETLIQKVVSPYLGTYGLYSNEGPCTHSCILEKRFLRRSRSGDILAKNPVVRSKSYNTPLLNPVAEHEAEGTASGGTSIRRHSVSEMTSCPEPQGFVDTPDQGPSGTFRSSPSPHSGPCPSRLYPPAHSPEQGPDHGSPPTSSPETLVDQILESVDSDSEGIFIDFGRGSRSSVSDFEAAGGRPSVV
uniprot
proteins
function
FUNCTION: Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. {ECO:0000250|UniProtKB:P85299}.
uniprot
proteins
mass_dalton
42540
uniprot
proteins
protein_family
PROTOR family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
387
uniprot
proteins