NSUN4
entrez
387338
canonical
uniprot
Q96CB9
canonical
ensembl
ENSG00000117481
resolver
ensp
ENSP00000419740
resolver
ensp
ENSP00000437758
resolver
ensp
ENSP00000582658
resolver
ensp
ENSP00000709877
resolver
genesymbol
NSUN4
resolver
hgnc
HGNC:31802
resolver
uniprot
A8K6S6
resolver
uniprot
A8K8I8
resolver
uniprot
B3KQ50
resolver
uniprot
B4DHA4
resolver
uniprot
Q5TDF7
resolver
uniprot
Q96AN8
resolver
uniprot
Q9HAJ8
resolver
uniprot_entry
A8K8I8_HUMAN
resolver
uniprot_entry
NSUN4_HUMAN
resolver
uniprot_sec
A8K6S6
resolver
uniprot_sec
B3KQ50
resolver
uniprot_sec
B4DHA4
resolver
uniprot_sec
Q5TDF7
resolver
uniprot_sec
Q96AN8
resolver
uniprot_sec
Q9HAJ8
resolver
amino_acid_sequence
MAALTLRGVRELLKRVDLATVPRRHRYKKKWAATEPKFPAVRLALQNFDMTYSVQFGDLWPSIRVSLLSEQKYGALVNNFAAWDHVSAKLEQLSAKDFVNEAISHWELQSEGGQSAAPSPASWACSPNLRCFTFDRGDISRFPPARPGSLGVMEYYLMDAASLLPVLALGLQPGDIVLDLCAAPGGKTLALLQTGCCRNLAANDLSPSRIARLQKILHSYVPEEIRDGNQVRVTSWDGRKWGELEGDTYDRVLVDVPCTTDRHSLHEEENNIFKRSRKKERQILPVLQVQLLAAGLLATKPGGHVVYSTCSLSHLQNEYVVQGAIELLANQYSIQVQVEDLTHFRRVFMDTFCFFSSCQVGELVIPNLMANFGPMYFCKMRRLT
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Mitochondrial RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as rRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:21531335, PubMed:23022348, PubMed:39019044). Involved in mitochondrial ribosome small subunit (SSU) maturation by catalyzing methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU) (PubMed:21531335, PubMed:23022348). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled (PubMed:21531335, PubMed:23022348). In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4 (PubMed:23022348). Also acts as a regulator of innate immunity by marking double-stranded mitochondrial RNAs(mt-dsRNAs) generated in response to stress: catalyzes m5C modification on mitochondrial RNAs, such as a mRNAs and lncRNAs, with a preference for the termini of light-strand lncRNAs, promoting their degradation and cytosolic release (PubMed:39019044). Modified light-strand lncRNAs are then recognized by C1QBP reader and recruited to the mitochondrial degradosome complex, which promotes their degradation (PubMed:39019044). {ECO:0000269|PubMed:21531335, ECO:0000269|PubMed:23022348, ECO:0000269|PubMed:39019044}.
uniprot
proteins
mass_dalton
43089
uniprot
proteins
mutagenesis
MUTAGEN 65; /note="V->R: Disrupts complex with MTERFD2; when associated with A-136, R-139 and A-141."; /evidence="ECO:0000269|PubMed:22949673"; MUTAGEN 136; /note="R->A: Disrupts complex with MTERFD2; when associated with R-65, R-139 and A-141."; /evidence="ECO:0000269|PubMed:22949673"; MUTAGEN 139; /note="I->R: Disrupts complex with MTERFD2; when associated with R-65, A-136, and A-141."; /evidence="ECO:0000269|PubMed:22949673"; MUTAGEN 141; /note="R->A: Disrupts complex with MTERFD2; when associated with R-65, A-136 and R-139."; /evidence="ECO:0000269|PubMed:22949673"; MUTAGEN 258; /note="C->W: Abolished methyltransferase activity; when associated with W-310."; /evidence="ECO:0000269|PubMed:39019044"; MUTAGEN 310; /note="C->W: Abolished methyltransferase activity; when associated with W-258."; /evidence="ECO:0000269|PubMed:39019044
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
RsmB/NOP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21531335
uniprot
proteins
pubmed
22949673
uniprot
proteins
pubmed
23022348
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
39019044
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21531335, ECO:0000269|PubMed:22949673, ECO:0000269|PubMed:23022348}.
uniprot
proteins