RBM5
entrez
10181
canonical
uniprot
P52756
canonical
ensembl
ENSG00000003756
resolver
ensp
ENSP00000343054
resolver
ensp
ENSP00000522754
resolver
ensp
ENSP00000522755
resolver
ensp
ENSP00000666350
resolver
genesymbol
RBM5
resolver
hgnc
HGNC:9902
resolver
uniprot
B2RA45
resolver
uniprot
B4DM16
resolver
uniprot
B4DMF9
resolver
uniprot
B4DZ63
resolver
uniprot
Q93021
resolver
uniprot
Q9BU14
resolver
uniprot
Q9HDA6
resolver
uniprot
Q9UKY8
resolver
uniprot
Q9UL24
resolver
uniprot_entry
RBM5_HUMAN
resolver
uniprot_sec
B2RA45
resolver
uniprot_sec
B4DM16
resolver
uniprot_sec
B4DMF9
resolver
uniprot_sec
B4DZ63
resolver
uniprot_sec
Q93021
resolver
uniprot_sec
Q9BU14
resolver
uniprot_sec
Q9HDA6
resolver
uniprot_sec
Q9UKY8
resolver
uniprot_sec
Q9UL24
resolver
amino_acid_sequence
MGSDKRVSRTERSGRYGSIIDRDDRDERESRSRRRDSDYKRSSDDRRGDRYDDYRDYDSPERERERRNSDRSEDGYHSDGDYGEHDYRHDISDERESKTIMLRGLPITITESDIREMMESFEGPQPADVRLMKRKTGVSRGFAFVEFYHLQDATSWMEANQKKLVIQGKHIAMHYSNPRPKFEDWLCNKCCLNNFRKRLKCFRCGADKFDSEQEVPPGTTESVQSVDYYCDTIILRNIAPHTVVDSIMTALSPYASLAVNNIRLIKDKQTQQNRGFAFVQLSSAMDASQLLQILQSLHPPLKIDGKTIGVDFAKSARKDLVLSDGNRVSAFSVASTAIAAAQWSSTQSQSGEGGSVDYSYLQPGQDGYAQYAQYSQDYQQFYQQQAGGLESDASSASGTAVTTTSAAVVSQSPQLYNQTSNPPGSPTEEAQPSTSTSTQAPAASPTGVVPGTKYAVPDTSTYQYDESSGYYYDPTTGLYYDPNSQYYYNSLTQQYLYWDGEKETYVPAAESSSHQQSGLPPAKEGKEKKEKPKSKTAQQIAKDMERWAKSLNKQKENFKNSFQPVNSLREEERRESAAADAGFALFEKKGALAERQQLIPELVRNGDEENPLKRGLVAAYSGDSDNEEELVERLESEEEKLADWKKMACLLCRRQFPNKDALVRHQQLSDLHKQNMDIYRRSRLSEQELEALELREREMKYRDRAAERREKYGIPEPPEPKRKKQFDAGTVNYEQPTKDGIDHSNIGNKMLQAMGWREGSGLGRKCQGITAPIEAQVRLKGAGLGAKGSAYGLSGADSYKDAVRKAMFARFTEME
uniprot
proteins
function
FUNCTION: Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. {ECO:0000269|PubMed:10949932, ECO:0000269|PubMed:12207175, ECO:0000269|PubMed:12581154, ECO:0000269|PubMed:15192330, ECO:0000269|PubMed:16585163, ECO:0000269|PubMed:18840686, ECO:0000269|PubMed:18851835, ECO:0000269|PubMed:21256132}.
uniprot
proteins
mass_dalton
92154
uniprot
proteins
protein_family
RBM5/RBM10 family
uniprot
proteins
pubmed
10486216
uniprot
proteins
pubmed
10497265
uniprot
proteins
pubmed
10508479
uniprot
proteins
pubmed
10949932
uniprot
proteins
pubmed
12207175
uniprot
proteins
pubmed
12581154
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15192330
uniprot
proteins
pubmed
16585163
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17332742
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18840686
uniprot
proteins
pubmed
18851835
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21256132
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
815
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18851835}.
uniprot
proteins