Tmem127
entrez
69470
canonical
uniprot
Q8BGP5
canonical
ensembl
ENSMUSG00000034850
resolver
ensp
ENSMUSP00000035434
resolver
ensp
ENSMUSP00000134629
resolver
enst
ENSMUST00000035871
resolver
enst
ENSMUST00000174288
resolver
genesymbol
Tmem127
resolver
uniprot
A2ARF9
resolver
uniprot
G3UZT7
resolver
uniprot
Q3TMK7
resolver
uniprot_entry
G3UZT7_MOUSE
resolver
uniprot_entry
TM127_MOUSE
resolver
uniprot_sec
A2ARF9
resolver
uniprot_sec
Q3TMK7
resolver
amino_acid_sequence
MYAPGGAGLPGGRRRRSPGSSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVNPDLLKDFCMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENDPYPAEYEVINQFQPPPAYTP
uniprot
proteins
function
FUNCTION: Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor. {ECO:0000250}.
uniprot
proteins
mass_dalton
25835
uniprot
proteins
protein_family
TMEM127 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 96..116; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 130..150; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins