SKP2
entrez
6502
canonical
uniprot
Q13309
canonical
ensembl
ENSG00000145604
resolver
ensp
ENSP00000274254
resolver
ensp
ENSP00000274255
resolver
ensp
ENSP00000503340
resolver
genesymbol
SKP2
resolver
genesymbol_syn
FBXL1
resolver
hgnc
HGNC:10901
resolver
uniprot
A8K5E0
resolver
uniprot
B4DJT4
resolver
uniprot
Q8TDZ0
resolver
uniprot
Q8TDZ1
resolver
uniprot
Q9BV69
resolver
uniprot_entry
SKP2_HUMAN
resolver
uniprot_sec
A8K5E0
resolver
uniprot_sec
B4DJT4
resolver
uniprot_sec
Q8TDZ0
resolver
uniprot_sec
Q8TDZ1
resolver
uniprot_sec
Q9BV69
resolver
amino_acid_sequence
MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLGHPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQKPSCL
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:9736735, PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1 (By similarity). Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:9736735, PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination (PubMed:22464731). {ECO:0000250|UniProtKB:Q9Z0Z3, ECO:0000269|PubMed:11931757, ECO:0000269|PubMed:12435635, ECO:0000269|PubMed:12769844, ECO:0000269|PubMed:12840033, ECO:0000269|PubMed:15342634, ECO:0000269|PubMed:15668399, ECO:0000269|PubMed:15949444, ECO:0000269|PubMed:16103164, ECO:0000269|PubMed:16262255, ECO:0000269|PubMed:16581786, ECO:0000269|PubMed:16951159, ECO:0000269|PubMed:17908926, ECO:0000269|PubMed:17962192, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:22770219, ECO:0000269|PubMed:32267835, ECO:0000269|PubMed:9736735}.; FUNCTION: Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. {ECO:0000269|PubMed:27194766}.
uniprot
proteins
mass_dalton
47761
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:22464731}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine resudues in response to DNA damage, promoting 'Lys-63'-linked ubiquitination of NBN. {ECO:0000250|UniProtKB:Q9Z0Z3}.; PTM: Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Deubiquitinated by USP13. {ECO:0000269|PubMed:21571647}.; PTM: Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes cytoplasmic retention. Deacetylated by SIRT3. {ECO:0000269|PubMed:22770219}.
uniprot
proteins
pubmed
11099048
uniprot
proteins
pubmed
11931757
uniprot
proteins
pubmed
11961546
uniprot
proteins
pubmed
12435635
uniprot
proteins
pubmed
12769844
uniprot
proteins
pubmed
12840033
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15342634
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15668399
uniprot
proteins
pubmed
15949444
uniprot
proteins
pubmed
16103164
uniprot
proteins
pubmed
16262255
uniprot
proteins
pubmed
16581786
uniprot
proteins
pubmed
16880511
uniprot
proteins
pubmed
16951159
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17908926
uniprot
proteins
pubmed
17962192
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21119685
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21571647
uniprot
proteins
pubmed
22464731
uniprot
proteins
pubmed
22770219
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27194766
uniprot
proteins
pubmed
32267835
uniprot
proteins
pubmed
7553852
uniprot
proteins
pubmed
9736735
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22770219}. Nucleus {ECO:0000269|PubMed:22770219}.
uniprot
proteins