RPS23
entrez
6228
canonical
uniprot
P62266
canonical
ensembl
ENSG00000186468
resolver
ensp
ENSP00000296674
resolver
ensp
ENSP00000498621
resolver
enst
ENST00000296674
resolver
enst
ENST00000651545
resolver
genesymbol
RPS23
resolver
hgnc
HGNC:10410
resolver
uniprot
A8K517
resolver
uniprot
P39028
resolver
uniprot
Q6IB08
resolver
uniprot_entry
A8K517_HUMAN
resolver
uniprot_entry
RS23_HUMAN
resolver
uniprot_sec
P39028
resolver
uniprot_sec
Q6IB08
resolver
amino_acid_sequence
MGKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRS
uniprot
proteins
disease_involvement
DISEASE: Brachycephaly, trichomegaly, and developmental delay (BTDD) [MIM:617412]: An autosomal dominant developmental disorder characterized by brachycephaly, ciliary trichomegaly, dysmorphic features of the face and hands, hearing loss, and developmental delay with short stature. Intellectual disability and autism spectrum disorder may be present in some patients. {ECO:0000269|PubMed:28257692}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:28257692). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:23636399, PubMed:25901680, PubMed:25957688). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:23636399, PubMed:25901680, PubMed:25957688). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25901680, PubMed:25957688). Plays an important role in translational accuracy (PubMed:28257692). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:28257692, ECO:0000269|PubMed:34516797}.
uniprot
proteins
mass_dalton
15808
uniprot
proteins
post_translational_modification
PTM: Hydroxylation at Pro-62 affects translation termination efficiency. {ECO:0000269|PubMed:24550447, ECO:0000269|PubMed:24550462, ECO:0000269|PubMed:28257692}.
uniprot
proteins
protein_family
Universal ribosomal protein uS12 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23636399
uniprot
proteins
pubmed
24524803
uniprot
proteins
pubmed
24550447
uniprot
proteins
pubmed
24550462
uniprot
proteins
pubmed
25901680
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
25957688
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28257692
uniprot
proteins
pubmed
34516797
uniprot
proteins
pubmed
8415000
uniprot
proteins
pubmed
8706699
uniprot
proteins
pubmed
9582194
uniprot
proteins
sequence_length
143
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q6SA96}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q6SA96, ECO:0000269|PubMed:25957688}.
uniprot
proteins