Cldn1
entrez
12737
canonical
uniprot
O88551
canonical
ensembl
ENSMUSG00000022512
resolver
ensp
ENSMUSP00000023154
resolver
enst
ENSMUST00000023154
resolver
genesymbol
Cldn1
resolver
uniprot
Q4FJV3
resolver
uniprot_entry
CLD1_MOUSE
resolver
uniprot_entry
Q4FJV3_MOUSE
resolver
amino_acid_sequence
MANAGLQLLGFILASLGWIGSIVSTALPQWKIYSYAGDNIVTAQAIYEGLWMSCVSQSTGQIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVSTIGMKCMRCLEDDEVQKMWMAVIGGIIFLISGLATLVATAWYGNRIVQEFYDPLTPINARYEFGQALFTGWAAASLCLLGGVLLSCSCPRKTTSYPTPRPYPKPTPSSGKDYV
uniprot
proteins
function
FUNCTION: Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. {ECO:0000269|PubMed:10508613, ECO:0000269|PubMed:11889141, ECO:0000269|PubMed:23407391}.
uniprot
proteins
mass_dalton
22881
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
10508613
uniprot
proteins
pubmed
10562289
uniprot
proteins
pubmed
10601346
uniprot
proteins
pubmed
11489913
uniprot
proteins
pubmed
11889141
uniprot
proteins
pubmed
12021270
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23407391
uniprot
proteins
pubmed
30734065
uniprot
proteins
pubmed
9647647
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:10508613, ECO:0000269|PubMed:10562289, ECO:0000269|PubMed:30734065, ECO:0000269|PubMed:9647647}. Cell membrane {ECO:0000269|PubMed:11889141}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:O95832}. Note=Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. {ECO:0000250|UniProtKB:O95832}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 164..184; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins