P3h2
entrez
210530
canonical
uniprot
Q8CG71
canonical
ensembl
ENSMUSG00000038168
resolver
ensp
ENSMUSP00000038056
resolver
enst
ENSMUST00000039990
resolver
genesymbol
P3h2
resolver
genesymbol_syn
Leprel1
resolver
uniprot
Q8C673
resolver
uniprot_entry
P3H2_MOUSE
resolver
uniprot_sec
Q8C673
resolver
amino_acid_sequence
MRESTWVSLLLLLLLPTPQRGGPQDGRRSPEPEPERGPLQPFDLLYASGVAAYYSGDYERAVRDLEAALSSHRRLRDIRTRCARHCAARRPLAPPGAGPGAELPFFRAVLERARCSRSCQSQRLGGPASRHRVSEDVRSDFQRRVPYNYLQRAYIKLNQLEKAMEAAHTFFMANPEHMEMQQDLEDYKATARVEAPLLDREAKPHLESYNAGVKHYEADDFESAIKYFEQALREYFNEDMECRALCEGPQRFEEYEYLGYKGGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYLMFHPDNEDVLDNVDFYESLLDDSTDPASIEAREDLTAFVKRHKLEAELIKLAAEGLGFSYAEPNYWISYGGRQDENRVPSGVNMDGAEVHGLSMGKKSPPKIGRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSQEQCRELHSVANGIMLVGDGYRGKTSPHTPNEKFEGATVLKALKFGYEGRVPLKSARLFYDISEKARKIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNDDFDGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTRGQRCAVALWFTLDPLYRELERIQADEVIAILDQEQRGKHGLNINPKDEL
uniprot
proteins
ec_number
1.14.11.7
uniprot
proteins
function
FUNCTION: Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (PubMed:24368846, PubMed:25645914). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (PubMed:25645914). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that have proline instead of 4-hydroxyproline in the third position (By similarity). {ECO:0000250|UniProtKB:Q8IVL5, ECO:0000269|PubMed:24368846, ECO:0000269|PubMed:25645914}.
uniprot
proteins
mass_dalton
80154
uniprot
proteins
protein_family
Leprecan family
uniprot
proteins
pubmed
15063763
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18487197
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24368846
uniprot
proteins
pubmed
25645914
uniprot
proteins
sequence_length
703
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8IVL5, ECO:0000255|PROSITE-ProRule:PRU10138}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q8IVL5}. Golgi apparatus {ECO:0000250|UniProtKB:Q8IVL5}.
uniprot
proteins