Gdpd1
entrez
303407
canonical
uniprot
Q0VGK4
canonical
ensembl
ENSRNOG00000060561
resolver
ensembl
ENSRNOG00055030193
resolver
ensembl
ENSRNOG00060030653
resolver
ensembl
ENSRNOG00065018381
resolver
ensp
ENSRNOP00000071339
resolver
ensp
ENSRNOP00000074578
resolver
ensp
ENSRNOP00055043397
resolver
ensp
ENSRNOP00060044380
resolver
ensp
ENSRNOP00065024639
resolver
enst
ENSRNOT00000079311
resolver
enst
ENSRNOT00000088182
resolver
enst
ENSRNOT00055052495
resolver
enst
ENSRNOT00060053414
resolver
enst
ENSRNOT00065030931
resolver
genesymbol
Gdpd1
resolver
uniprot
A0A0G2K080
resolver
uniprot_entry
A0A0G2K080_RAT
resolver
uniprot_entry
GDPD1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Lysophospholipase D activity is increased by magnesium and manganese and inhibited by calcium in a concentration dependent manner (By similarity). Loss of lysophospholipase D activity by addition of EDTA (By similarity). {ECO:0000250|UniProtKB:Q8N9F7, ECO:0000250|UniProtKB:Q9CRY7}.
uniprot
proteins
amino_acid_sequence
MSSTAAFCLLSTLGGYLVTSFLLLKYPALLHQRKKQRFLSRHISHRGGAGENLENTMAAFQHAVTIGTDMLELDCHITKDEQVVVSHDANLKRSTGVNVNVSDLKYCELPPYLCKLDVPFQRACKCEGTDTRIPLLKEVFEAFPETPINIDIKVNNNVLIQKVSELVKQYKREHLTVWGNASSEIVDKCYKENSDIPILFSLQRVLLILGLFFTGLLPFVPIREQFFEIPMPSIILKLKEPHIISKGHKFLIWLSDTLLMRKALFDHLTARGIQVYIWVLNEEHEYKRAFDLGATGVMTDYPTKLKEFLNNMSA
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
function
FUNCTION: Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis from both N-acyl-lysoplasmenylethanolamin (N-acyl-lysoPlsEt) and N-acyl-lysophosphatidylethanolamin (N-acyl-lysoPE). In addition, hydrolyzes glycerophospho-N-acylethanolamine to N-acylethanolamine. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine. {ECO:0000250|UniProtKB:Q9CRY7}.
uniprot
proteins
mass_dalton
35811
uniprot
proteins
protein_family
Glycerophosphoryl diester phosphodiesterase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8N9F7}. Membrane {ECO:0000250|UniProtKB:Q8N9F7}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8N9F7}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8N9F7}. Note=Concentrated at the perinuclear region and the cell periphery. {ECO:0000250|UniProtKB:Q8N9F7}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins