Hnf1a
entrez
21405
canonical
uniprot
P22361
canonical
ensembl
ENSMUSG00000029556
resolver
ensp
ENSMUSP00000031535
resolver
enst
ENSMUST00000031535
resolver
genesymbol
Hnf1a
resolver
genesymbol_syn
Hnf-1
resolver
genesymbol_syn
Hnf-1a
resolver
genesymbol_syn
Tcf1
resolver
uniprot
E9QP86
resolver
uniprot
Q66JY7
resolver
uniprot_entry
HNF1A_MOUSE
resolver
uniprot_entry
Q66JY7_MOUSE
resolver
uniprot_sec
E9QP86
resolver
amino_acid_sequence
MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLMVGEGPLDKGESCGGSRGDLTELPNGLGETRGSEDDTDDDGEDFAPPILKELENLSPEEAAHQKAVVESLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYNGPPPGPGPGPALPAHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGGPLVTVSAALHQVSPTGLEPSSLLSTEAKLVSATGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVAQSPFMATMAQLQSPHALYSHKPEVAQYTHTSLLPQTMLITDTNLSTLASLTPTKQVFTSDTEASSEPGLHEPPSPATTIHIPSQDPSNIQHLQPAHRLSTSPTVSSSSLVLYQSSDSNGHSHLLPSNHSVIETFISTQMASSSQ
uniprot
proteins
function
FUNCTION: Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (PubMed:19289501). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:10966642). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (PubMed:30555544). {ECO:0000269|PubMed:10966642, ECO:0000269|PubMed:19289501, ECO:0000269|PubMed:30555544}.
uniprot
proteins
mass_dalton
67253
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated in s SPOP-dependent manner; leading to prteasomal degradation. {ECO:0000250|UniProtKB:P20823}.
uniprot
proteins
protein_family
HNF1 homeobox family
uniprot
proteins
pubmed
10966642
uniprot
proteins
pubmed
11106484
uniprot
proteins
pubmed
11439029
uniprot
proteins
pubmed
1354855
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19289501
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2263635
uniprot
proteins
pubmed
30555544
uniprot
proteins
pubmed
9566924
uniprot
proteins
sequence_length
628
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins