Cdc25c
entrez
12532
canonical
uniprot
P48967
canonical
ensembl
ENSMUSG00000044201
resolver
ensp
ENSMUSP00000055427
resolver
ensp
ENSMUSP00000298273
resolver
ensp
ENSMUSP00000298274
resolver
enst
ENSMUST00000060710
resolver
genesymbol
Cdc25c
resolver
genesymbol_syn
Cdc25m1
resolver
uniprot
Q3UR74
resolver
uniprot
Q99KG6
resolver
uniprot_entry
MPIP3_MOUSE
resolver
uniprot_entry
Q3UR74_MOUSE
resolver
uniprot_sec
Q99KG6
resolver
amino_acid_sequence
MSTGPIPPASEEGSFVSAPSFRSKQRKILHLLLERNTSFTIRSDFPESPKDKLHDSANLSILSGGTPKCCLDLSNLSSGEMSASPLTTSADLEDNGSLDSSGPLDRQLTGKDFHQDLMKGIPVQLLCSTPNAMNHGHRKKIAKRSTSAHKENINTSLKALEWEAPRTPRFRKMPGGPLTSPLCELEMKHLGSPITTVPKLSQNVKLEDQERISEDPMECSLGDQDAKGLSLRKMVPLCDMNAIQMEEEESGSELLIGDFSKVCVLPTVPGKHPDLKYISPDTVAALLSGKFQSVIERFYIIDCRYPYEYLGGHILGALNLHSQKELHEFFLRKPVVPLDIQKRVIIVFLCEFSSERGPRMCRSLREKDRALNQYPALYYPELYILKGGYRDFFPEYMELCDPQSYCPMLHQDHQAELLSWRSQSKAQEGERQLQGQIALLVKGASPQ
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity. {ECO:0000250|UniProtKB:P30307}.
uniprot
proteins
mass_dalton
50046
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase activity (By similarity). Phosphorylated by CHEK1 and MAPKAPK2. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase activity. Phosphorylation by PLK3 at Ser-213 promotes nuclear translocation. Ser-220 is a minor phosphorylation site (By similarity). Phosphorylation by CDK1 occurs at G2 and G2-M transition and leads to increased activity (By similarity). {ECO:0000250|UniProtKB:P30307}.
uniprot
proteins
protein_family
MPI phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7601309
uniprot
proteins
pubmed
8276463
uniprot
proteins
sequence_length
447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P30307}.
uniprot
proteins