Slc6a20a
entrez
102680
canonical
uniprot
Q8VDB9
canonical
ensembl
ENSMUSG00000036814
resolver
ensp
ENSMUSP00000047690
resolver
enst
ENSMUST00000040960
resolver
genesymbol
Slc6a20a
resolver
genesymbol_syn
Slc6a20
resolver
genesymbol_syn
Xt3s1
resolver
genesymbol_syn
Xtm3s1
resolver
genesymbol_syn
Xtrp3s1
resolver
uniprot
Q3USE2
resolver
uniprot_entry
S620A_MOUSE
resolver
uniprot_sec
Q3USE2
resolver
amino_acid_sequence
MEKARPQWGHPLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWGFWYLFHSFQDPLPWSVCPLNSNHTGYDEECEKASSTQYFWYRKTLNISPSIQENGGVQWEPALCLTLAWLMVYLCILRGTESTGKVVYFTASMPYCVLIIYLVRGLTLHGATNGLMYMFTPKMEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSIINSSTSIFASIVTFSIYGFKATFNYENCLNKVILLLTNSFDLEDGFLTVSNLEEVKNYLASTYPNKYSEVFPHIRNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKVISSYLPKEAISGLVCLINCAVGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLKRFESDLRAMTGRTLSWYWKVMWAFVSPLLIVGLFIFYLSDYILTGTLQYQAWDATQGQLVTKDYPPHALAVIGLLVASSTMCIPLVALGTFIRNRLKRGGSAPVA
uniprot
proteins
function
FUNCTION: Mediates the Na(+)- and Cl(-)-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids (PubMed:15689184). Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents (PubMed:33428810). {ECO:0000269|PubMed:15689184, ECO:0000269|PubMed:33428810}.
uniprot
proteins
mass_dalton
66178
uniprot
proteins
protein_family
SLC6A20 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
12461651
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15632147
uniprot
proteins
pubmed
15689184
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16174864
uniprot
proteins
pubmed
33428810
uniprot
proteins
sequence_length
592
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:16174864}; Multi-pass membrane protein {ECO:0000269|PubMed:16174864}. Note=Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi. {ECO:0000269|PubMed:16174864}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 43..63; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 80..100; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 166..186; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 195..215; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 242..262; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 390..410; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 432..452; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 466..486; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 505..525; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 555..575; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins