Ankrd28
entrez
105522
canonical
uniprot
Q505D1
canonical
ensembl
ENSMUSG00000014496
resolver
ensp
ENSMUSP00000014640
resolver
ensp
ENSMUSP00000153992
resolver
ensp
ENSMUSP00000154197
resolver
enst
ENSMUST00000014640
resolver
enst
ENSMUST00000227089
resolver
enst
ENSMUST00000227863
resolver
genesymbol
Ankrd28
resolver
uniprot
A0A2I3BQ07
resolver
uniprot
A0A2I3BQJ1
resolver
uniprot_entry
A0A2I3BQ07_MOUSE
resolver
uniprot_entry
A0A2I3BQJ1_MOUSE
resolver
uniprot_entry
ANR28_MOUSE
resolver
amino_acid_sequence
MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQILLKHSADVNARDKNWQTPLHIAAANKAVKCAESLVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGANVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYVLKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSATSVDANPAVVDNHGYTALHWACYNGHETCVELLLEQDVFQKIDGNAFSPLHCAVINDNEGAAEMLIDSLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSQNAQVNSADSTGKTPLMMAAENGQTNTVEMLVSSASADLTLQDKSKNTALHLACGKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSPLTSLTFNAINRYTNTSKTVSFEALPIMRNEASSYCSFNNIGGEQEYLYTDVDELNDSDSETY
uniprot
proteins
function
FUNCTION: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation (By similarity). Involved in the PP6-mediated dephosphorylation of MOB1 and induced focal adhesion assembly during cell migration (By similarity). {ECO:0000250|UniProtKB:O15084}.
uniprot
proteins
mass_dalton
112898
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the ECS(RAB40C) complex leading to its degradation and decreased PP6 activity. {ECO:0000250|UniProtKB:O15084}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16564677
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1053
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:O15084}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O15084}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O15084}. Note=Seems to be excluded from nucleoli. Mostly localized in the cytosol, but a fraction could be observed at the lamellipodia (By similarity). {ECO:0000250|UniProtKB:O15084}.
uniprot
proteins