Babam1
entrez
68251
canonical
uniprot
Q3UI43
canonical
ensembl
ENSMUSG00000031820
resolver
ensp
ENSMUSP00000002473
resolver
ensp
ENSMUSP00000230962
resolver
enst
ENSMUST00000002473
resolver
genesymbol
Babam1
resolver
genesymbol_syn
Merit40
resolver
genesymbol_syn
Nba1
resolver
uniprot
Q8C5Q8
resolver
uniprot
Q99JU2
resolver
uniprot
Q9CTJ4
resolver
uniprot_entry
BABA1_MOUSE
resolver
uniprot_sec
Q8C5Q8
resolver
uniprot_sec
Q99JU2
resolver
uniprot_sec
Q9CTJ4
resolver
amino_acid_sequence
MEVAEANSPTEEEEEEEEEGEETISEPRPHTRSNPEGAEDRALGAQASVGSRSEGEGEAATADGGAASVPGAGPKPWQVPASASEVQIRTPRVNCPEKVIICLDLSEEMSVPKLESFNGSRTNALNVSQKMVEMFVRTKHKIDKSHEFALVVVNDDSAWLSGLTSDPRELCSCLYDLETASCSTFNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPYFFFDIVYIHNGTEEKEEDMSWKDMFAFMGSLDTKGASYKYEVALAGPALELHNCMAKLLAHPLQRPCQTHASYSLLEEDEEAGEEEATV
uniprot
proteins
function
FUNCTION: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. {ECO:0000250|UniProtKB:Q9NWV8}.
uniprot
proteins
mass_dalton
36793
uniprot
proteins
protein_family
BABAM1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NWV8}. Nucleus {ECO:0000250|UniProtKB:Q9NWV8}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000250|UniProtKB:Q9NWV8}.
uniprot
proteins