Hcst
entrez
23900
canonical
uniprot
Q9QUJ0
canonical
ensembl
ENSMUSG00000064109
resolver
ensp
ENSMUSP00000074573
resolver
genesymbol
Hcst
resolver
genesymbol_syn
Dap10
resolver
genesymbol_syn
Kap10
resolver
uniprot
Q9R1E7
resolver
uniprot_entry
HCST_MOUSE
resolver
uniprot_sec
Q9R1E7
resolver
amino_acid_sequence
MDPPGYLLFLLLLPVAASQTSAGSCSGCGTLSLPLLAGLVAADAVMSLLIVGVVFVCMRPHGRPAQEDGRVYINMPGRG
uniprot
proteins
function
FUNCTION: Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as a docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells. {ECO:0000269|PubMed:10528161, ECO:0000269|PubMed:12426565, ECO:0000269|PubMed:15365099, ECO:0000269|PubMed:16086018, ECO:0000269|PubMed:16887996, ECO:0000269|PubMed:17100879}.
uniprot
proteins
mass_dalton
8114
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; PIK3R1 and GRB2 associate specifically with tyrosine-phosphorylated HCST. {ECO:0000269|PubMed:10528161}.; PTM: O-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
DAP10 family
uniprot
proteins
pubmed
10426994
uniprot
proteins
pubmed
10528161
uniprot
proteins
pubmed
11491539
uniprot
proteins
pubmed
12426564
uniprot
proteins
pubmed
12426565
uniprot
proteins
pubmed
15294961
uniprot
proteins
pubmed
15365099
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16086018
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16887996
uniprot
proteins
pubmed
17100879
uniprot
proteins
pubmed
17785813
uniprot
proteins
pubmed
19251634
uniprot
proteins
sequence_length
79
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:17100879}; Single-pass type I membrane protein {ECO:0000269|PubMed:17100879}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins