ARRDC3
entrez
57561
canonical
uniprot
Q96B67
canonical
ensembl
ENSG00000113369
resolver
ensp
ENSP00000265138
resolver
enst
ENST00000265138
resolver
genesymbol
ARRDC3
resolver
genesymbol_syn
KIAA1376
resolver
hgnc
HGNC:29263
resolver
uniprot
A8K6T8
resolver
uniprot
Q9P2H1
resolver
uniprot_entry
ARRD3_HUMAN
resolver
uniprot_sec
A8K6T8
resolver
uniprot_sec
Q9P2H1
resolver
amino_acid_sequence
MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
uniprot
proteins
function
FUNCTION: Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550). {ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23208550}.
uniprot
proteins
mass_dalton
46395
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="K->E: Abolishes interaction with ADRB2; when associated with E-52; E-85 and E-139."; /evidence="ECO:0000269|PubMed:25220262"; MUTAGEN 52; /note="R->E: Abolishes interaction with ADRB2; when associated with E-48; E-85 and E-139."; /evidence="ECO:0000269|PubMed:25220262"; MUTAGEN 56; /note="K->E: Nearly abolishes interaction with ADRB2; when associated with E-58; E-135 and E-153."; /evidence="ECO:0000269|PubMed:25220262"; MUTAGEN 58; /note="R->E: Nearly abolishes interaction with ADRB2; when associated with E-56; E-135 and E-153."; /evidence="ECO:0000269|PubMed:25220262"; MUTAGEN 85; /note="K->E: Abolishes interaction with ADRB2; when associated with E-48; E-52 and E-139."; /evidence="ECO:0000269|PubMed:25220262"; MUTAGEN 135; /note="R->E: Nearly abolishes interaction with ADRB2; when associated with E-56; E-58 and E-153."; /evidence="ECO:0000269|PubMed:25220262"; MUTAGEN 139; /note="K->E: Abolishes interaction with ADRB2; when associated with E-48; E-52 and E-85."; /evidence="ECO:0000269|PubMed:25220262"; MUTAGEN 153; /note="K->E: Nearly abolishes interaction with ADRB2; when associated with E-56; E-58 and E-135."; /evidence="ECO:0000269|PubMed:25220262"; MUTAGEN 346..349; /note="PPSY->AASA: Strongly reduces interaction with NEDD4. Abolishes interaction with NEDD4; when associated with 391-A--A-394. Abolishes interaction with HGS; when associated with 391-A--A-394."; /evidence="ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23208550"; MUTAGEN 391..394; /note="PPLY->AALA: Abolishes interaction with NEDD4; when associated with 346-A--A-349."; /evidence="ECO:0000269|PubMed:20559325
uniprot
proteins
protein_family
Arrestin family
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16269462
uniprot
proteins
pubmed
20559325
uniprot
proteins
pubmed
21191027
uniprot
proteins
pubmed
21982743
uniprot
proteins
pubmed
23208550
uniprot
proteins
pubmed
23886940
uniprot
proteins
pubmed
24379409
uniprot
proteins
pubmed
25220262
uniprot
proteins
sequence_length
414
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:23208550}. Cell membrane {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23208550}; Peripheral membrane protein {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:20559325}; Cytoplasmic side {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:20559325}. Lysosome {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:23208550}. Endosome {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:23208550}. Early endosome {ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23208550}. Note=Associated with plasma membrane, as well as with endosomes and lysosomes during endocytosis (PubMed:16269462, PubMed:20559325, PubMed:23208550). {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23208550}.
uniprot
proteins