MIMS2
entrez
116151
canonical
uniprot
Q96KR6
canonical
ensembl
ENSG00000124098
resolver
ensp
ENSP00000360437
resolver
enst
ENST00000371384
resolver
genesymbol
MIMS2
resolver
genesymbol_syn
C20orf108
resolver
genesymbol_syn
FAM210B
resolver
hgnc
HGNC:16102
resolver
uniprot
B2RBQ9
resolver
uniprot
E1P5Y7
resolver
uniprot
Q8WVN2
resolver
uniprot
Q9BYL6
resolver
uniprot
Q9H418
resolver
uniprot_entry
MIMS2_HUMAN
resolver
uniprot_sec
B2RBQ9
resolver
uniprot_sec
E1P5Y7
resolver
uniprot_sec
Q8WVN2
resolver
uniprot_sec
Q9BYL6
resolver
uniprot_sec
Q9H418
resolver
amino_acid_sequence
MAGLLALLGPAGRVGARVRPRATWLLGATAPCAPPPLALALLPPRLDARLLRTARGDCRGHQDPSQATGTTGSSVSCTEEKKQSKSQQLKKIFQEYGTVGVSLHIGISLISLGIFYMVVSSGVDMPAILLKLGFKESLVQSKMAAGTSTFVVAYAIHKLFAPVRISITLVSVPLIVRYFRKVGFFKPPAAKP
uniprot
proteins
function
FUNCTION: Mitochondrial inner membrane adapter protein essential for terminal erythroid differentiation and heme biosynthesis (PubMed:26968549, PubMed:28594398). Facilitates formation of an oligomeric mitochondrial iron transport complex required for iron acquisition during heme synthesis, although it does not function as a direct iron transporter (By similarity). Directly interacts with terminal heme synthesis enzymes PPOX and FECH to enhance ferrochelatase activity and couple iron import with heme synthesis (By similarity). Regulates mitochondrial energy metabolism through interaction with ATP synthase subunits (PubMed:36374104). {ECO:0000250|UniProtKB:Q9D8B6, ECO:0000269|PubMed:26968549, ECO:0000269|PubMed:28594398, ECO:0000269|PubMed:36374104}.
uniprot
proteins
mass_dalton
20424
uniprot
proteins
protein_family
MIMS family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26968549
uniprot
proteins
pubmed
28594398
uniprot
proteins
pubmed
36374104
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:26968549, ECO:0000305|PubMed:28594398}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 99..119; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins