NCOA2
entrez
10499
canonical
uniprot
Q15596
canonical
ensembl
ENSG00000140396
resolver
ensp
ENSP00000399968
resolver
ensp
ENSP00000562954
resolver
ensp
ENSP00000562955
resolver
ensp
ENSP00000562957
resolver
ensp
ENSP00000562958
resolver
ensp
ENSP00000581601
resolver
ensp
ENSP00000788664
resolver
enst
ENST00000452400
resolver
enst
ENST00000892895
resolver
enst
ENST00000892896
resolver
enst
ENST00000892898
resolver
enst
ENST00000892899
resolver
enst
ENST00000911542
resolver
genesymbol
NCOA2
resolver
genesymbol_syn
BHLHE75
resolver
genesymbol_syn
SRC2
resolver
genesymbol_syn
TIF2
resolver
hgnc
HGNC:7669
resolver
uniprot
B4DPW8
resolver
uniprot
Q14CD2
resolver
uniprot_entry
B4DPW8_HUMAN
resolver
uniprot_entry
NCOA2_HUMAN
resolver
uniprot_sec
Q14CD2
resolver
amino_acid_sequence
MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLSSNINFPINGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQMEPSPLASSLSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKDLSQESSSTAPGSEVTIKQEPVSPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSELEMNMGGPQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQLQHRLQAQQNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSPPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDTTRKYC
uniprot
proteins
disease_involvement
DISEASE: Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. {ECO:0000269|PubMed:12676584, ECO:0000269|PubMed:15657427, ECO:0000269|PubMed:9558366}.
uniprot
proteins
function
FUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}.
uniprot
proteins
mass_dalton
159157
uniprot
proteins
mutagenesis
MUTAGEN 644..645; /note="LL->AA: By itself, does not affect nuclear receptor binding or transcriptional coactivation. Abrogates ligand-induced nuclear receptor binding and transactivation; when associated with 693-A-A-694 and 748-A-A-749."; /evidence="ECO:0000269|PubMed:9430642"; MUTAGEN 693..694; /note="LL->AA: By itself, does not affect nuclear receptor binding or transcriptional coactivation. Abrogates ligand-induced nuclear receptor binding and transactivation; when associated with 644-A-A-665 and 748-A-A-749."; /evidence="ECO:0000269|PubMed:9430642"; MUTAGEN 748..749; /note="LL->AA: By itself, does not affect nuclear receptor binding or transcriptional coactivation. Abrogates ligand-induced nuclear receptor binding and transactivation; when associated with 644-A-A-665 and 693-A-A-694."; /evidence="ECO:0000269|PubMed:9430642"; MUTAGEN 1079..1083; /note="LLDQL->AADQA: Reduces transcriptional coactivation and disrupts interaction with CREBBP/CBP."; /evidence="ECO:0000269|PubMed:9430642"; MUTAGEN 1081..1082; /note="DQ->AA: Has little effect on transcriptional coactivation."; /evidence="ECO:0000269|PubMed:9430642
uniprot
proteins
post_translational_modification
PTM: Acetylated. Deacetylation at Lys-780 by SIRT6 stimulates its ability to coactivate PPARA. {ECO:0000250|UniProtKB:Q61026}.
uniprot
proteins
protein_family
SRC/p160 nuclear receptor coactivator family
uniprot
proteins
pubmed
10478845
uniprot
proteins
pubmed
10594042
uniprot
proteins
pubmed
11250900
uniprot
proteins
pubmed
11971985
uniprot
proteins
pubmed
12676584
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15657427
uniprot
proteins
pubmed
16957778
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17116691
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18690216
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19481530
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21152046
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22504882
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23508108
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25452582
uniprot
proteins
pubmed
26553876
uniprot
proteins
pubmed
27694446
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
31419141
uniprot
proteins
pubmed
32631515
uniprot
proteins
pubmed
33335203
uniprot
proteins
pubmed
35503419
uniprot
proteins
pubmed
8670870
uniprot
proteins
pubmed
9430642
uniprot
proteins
pubmed
9558366
uniprot
proteins
pubmed
9590696
uniprot
proteins
sequence_length
1464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8670870}.
uniprot
proteins