KCNK17
entrez
89822
canonical
uniprot
Q96T54
canonical
ensembl
ENSG00000124780
resolver
ensp
ENSP00000362328
resolver
ensp
ENSP00000401271
resolver
genesymbol
KCNK17
resolver
genesymbol_syn
TALK2
resolver
genesymbol_syn
TASK4
resolver
hgnc
HGNC:14465
resolver
uniprot
E9PB46
resolver
uniprot
Q5TCF4
resolver
uniprot
Q8TAW4
resolver
uniprot
Q9BXD1
resolver
uniprot
Q9H592
resolver
uniprot_entry
KCNKH_HUMAN
resolver
uniprot_sec
E9PB46
resolver
uniprot_sec
Q5TCF4
resolver
uniprot_sec
Q8TAW4
resolver
uniprot_sec
Q9BXD1
resolver
uniprot_sec
Q9H592
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Ba(2+), quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane. {ECO:0000269|PubMed:11248242, ECO:0000269|PubMed:11263999, ECO:0000269|PubMed:36063992}.
uniprot
proteins
amino_acid_sequence
MYRPRARAAPEGRVRGCAVPSTVLLLLAYLAYLALGTGVFWTLEGRAAQDSSRSFQRDKWELLQNFTCLDRPALDSLIRDVVQAYKNGASLLSNTTSMGRWELVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVVLNRLGHLMQQGVNHWASRLGGTWQDPDKARWLAGSGALLSGLLLFLLLPPLLFSHMEGWSYTEGFYFAFITLSTVGFGDYVIGMNPSQRYPLWYKNMVSLWILFGMAWLALIIKLILSQLETPGRVCSCCHHSSKEDFKSQSWRQGPDREPESHSPQQGCYPEGPMGIIQHLEPSAHAAGCGKDS
uniprot
proteins
function
FUNCTION: K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:11248242, PubMed:11263999, PubMed:26919430, PubMed:36063992). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:36063992). Present in the cardiac conduction system where it may regulate action potential duration and beating frequency of cardiac myocytes (PubMed:24972929). Permeable to other monovalent cations such as Rb(+) and Cs(+) (By similarity) (PubMed:26919430). {ECO:0000250|UniProtKB:Q96T55, ECO:0000269|PubMed:11248242, ECO:0000269|PubMed:11263999, ECO:0000269|PubMed:24972929, ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:36063992}.
uniprot
proteins
mass_dalton
36895
uniprot
proteins
mutagenesis
MUTAGEN 88; /note="G->A: Slightly increased current conductance when compared to wild-type."; /evidence="ECO:0000269|PubMed:24972929"; MUTAGEN 88; /note="G->E: 3.6-fold increased current conductance when compared to wild-type."; /evidence="ECO:0000269|PubMed:24972929"; MUTAGEN 88; /note="G->K: 7.3-fold increased current conductance when compared to wild-type."; /evidence="ECO:0000269|PubMed:24972929
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
11248242
uniprot
proteins
pubmed
11263999
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24972929
uniprot
proteins
pubmed
26919430
uniprot
proteins
pubmed
36063992
uniprot
proteins
sequence_length
332
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24972929}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..43; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 180..200; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 244..264; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins