Cygb
entrez
114886
canonical
uniprot
Q9CX80
canonical
ensembl
ENSMUSG00000020810
resolver
ensp
ENSMUSP00000021166
resolver
ensp
ENSMUSP00000261605
resolver
enst
ENSMUST00000021166
resolver
genesymbol
Cygb
resolver
uniprot
Q546K1
resolver
uniprot_entry
CYGB_MOUSE
resolver
uniprot_entry
Q546K1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: The nitric oxide dioxygenase activity is activated by a reducing system composed of cytochrome b5, its upstream reductase CYB5R3 and NADH. {ECO:0000269|PubMed:33334890}.
uniprot
proteins
amino_acid_sequence
MEKVPGDMEIERRERSEELSEAERKAVQATWARLYANCEDVGVAILVRFFVNFPSAKQYFSQFRHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKVEPMYFKILSGVILEVIAEEFANDFPVETQKAWAKLRGLIYSHVTAAYKEVGWVQQVPNTTTPPATLPSSGP
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
ec_number
1.14.12.-
uniprot
proteins
ec_number
1.15.1.1
uniprot
proteins
ec_number
1.7.-.-
uniprot
proteins
function
FUNCTION: Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability (PubMed:19147491, PubMed:28393874, PubMed:33334890, PubMed:34930834). Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption (PubMed:19147491, PubMed:28393874, PubMed:33334890). By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone (PubMed:19147491, PubMed:28393874). Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide (By similarity). Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress (PubMed:34930834). Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier (By similarity). {ECO:0000250|UniProtKB:Q8WWM9, ECO:0000269|PubMed:19147491, ECO:0000269|PubMed:28393874, ECO:0000269|PubMed:33334890, ECO:0000269|PubMed:34930834}.
uniprot
proteins
mass_dalton
21466
uniprot
proteins
post_translational_modification
PTM: The formation of an intramolecular disulfide bond between cysteines Cys-38 and Cys-83 specifically enhances the nitrite reductase activity. {ECO:0000250|UniProtKB:Q8WWM9}.
uniprot
proteins
protein_family
Globin family
uniprot
proteins
pubmed
11919282
uniprot
proteins
pubmed
14660570
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15663964
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19147491
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28393874
uniprot
proteins
pubmed
33334890
uniprot
proteins
pubmed
34930834
uniprot
proteins
sequence_length
190
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14660570, ECO:0000269|PubMed:15663964, ECO:0000269|PubMed:34930834}. Nucleus {ECO:0000269|PubMed:14660570, ECO:0000269|PubMed:15663964}. Note=Nuclear localization is observed in neurons. {ECO:0000269|PubMed:14660570}.
uniprot
proteins