Smim30
entrez
66520
canonical
uniprot
F2Z3Y9
canonical
ensembl
ENSMUSG00000052419
resolver
ensp
ENSMUSP00000116702
resolver
ensp
ENSMUSP00000120110
resolver
ensp
ENSMUSP00000139650
resolver
ensp
ENSMUSP00000140155
resolver
enst
ENSMUST00000139231
resolver
enst
ENSMUST00000155856
resolver
enst
ENSMUST00000185219
resolver
enst
ENSMUST00000185361
resolver
genesymbol
Smim30
resolver
genesymbol_syn
Mavi1
resolver
uniprot
Q8CF75
resolver
uniprot_entry
SIM30_MOUSE
resolver
uniprot_sec
Q8CF75
resolver
amino_acid_sequence
MNSVSTQLILVLASLLLILPVVEAVEAGDAIALLLGVVLSITGICACLGIYARKRNGQM
uniprot
proteins
function
FUNCTION: Negatively regulates antiviral innate immune responses (PubMed:37656786). Disrupts the interaction of antiviral protein MAVS with innate immune receptor RIGI and inhibits MAVS aggregation, resulting in the repression of type I interferon signaling and innate immune responses (By similarity). {ECO:0000250|UniProtKB:A4D0T7, ECO:0000269|PubMed:37656786}.
uniprot
proteins
mass_dalton
6109
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
37656786
uniprot
proteins
sequence_length
59
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A4D0T7}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:A4D0T7}. Mitochondrion membrane {ECO:0000250|UniProtKB:A4D0T7}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:A4D0T7}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins