SULT1C4
entrez
27233
canonical
uniprot
O75897
canonical
ensembl
ENSG00000198075
resolver
ensp
ENSP00000272452
resolver
ensp
ENSP00000387225
resolver
genesymbol
SULT1C4
resolver
genesymbol_syn
SULT1C2
resolver
hgnc
HGNC:11457
resolver
uniprot
Q069I8
resolver
uniprot
Q08AS5
resolver
uniprot
Q53S63
resolver
uniprot
Q6PD90
resolver
uniprot_entry
Q6PD90_HUMAN
resolver
uniprot_entry
ST1C4_HUMAN
resolver
uniprot_sec
Q069I8
resolver
uniprot_sec
Q08AS5
resolver
uniprot_sec
Q53S63
resolver
amino_acid_sequence
MALHDMEDFTFDGTKRLSVNYVKGILQPTDTCDIWDKIWNFQAKPDDLLISTYPKAGTTWTQEIVELIQNEGDVEKSKRAPTHQRFPFLEMKIPSLGSGLEQAHAMPSPRILKTHLPFHLLPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAPGTWEEYFETFLAGKVCWGSWHEHVKGWWEAKDKHRILYLFYEDMKKNPKHEIQKLAEFIGKKLDDKVLDKIVHYTSFDVMKQNPMANYSSIPAEIMDHSISPFMRKGAVGDWKKHFTVAQNERFDEDYKKKMTDTRLTFHFQF
uniprot
proteins
ec_number
2.8.2.1
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Can also sulfonate estrogenic compounds, however, the dietary flavonoids (phytoestrogen) and environmental estrogens, like bisphenol A are better substrates than 17beta-estradiol (E2) (PubMed:17425406, PubMed:26948952, PubMed:28222028, PubMed:9852044). Mediates the sulfation of doxorubicin and its analog epirubicin, two antitumor anthracyclines (PubMed:26948952). {ECO:0000269|PubMed:17425406, ECO:0000269|PubMed:26948952, ECO:0000269|PubMed:28222028, ECO:0000269|PubMed:9852044}.
uniprot
proteins
mass_dalton
35520
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
10783263
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17425406
uniprot
proteins
pubmed
26948952
uniprot
proteins
pubmed
28222028
uniprot
proteins
pubmed
9852044
uniprot
proteins
sequence_length
302
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:28222028}.
uniprot
proteins