LEFTY2
entrez
7044
canonical
uniprot
O00292
canonical
ensembl
ENSG00000143768
resolver
ensp
ENSP00000355785
resolver
ensp
ENSP00000388009
resolver
ensp
ENSP00000686404
resolver
genesymbol
LEFTY2
resolver
genesymbol_syn
EBAF
resolver
genesymbol_syn
LEFTA
resolver
genesymbol_syn
LEFTYA
resolver
genesymbol_syn
TGFB4
resolver
hgnc
HGNC:3122
resolver
uniprot
B3KNH4
resolver
uniprot
B4E332
resolver
uniprot
E9PDM4
resolver
uniprot
O75611
resolver
uniprot
Q5TE89
resolver
uniprot
Q8NBQ9
resolver
uniprot_entry
LFTY2_HUMAN
resolver
uniprot_sec
B3KNH4
resolver
uniprot_sec
B4E332
resolver
uniprot_sec
E9PDM4
resolver
uniprot_sec
O75611
resolver
uniprot_sec
Q5TE89
resolver
uniprot_sec
Q8NBQ9
resolver
amino_acid_sequence
MWPLWLCWALWVLPLAGPGAALTEEQLLGSLLRQLQLSEVPVLDRADMEKLVIPAHVRAQYVVLLRRSHGDRSRGKRFSQSFREVAGRFLASEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLRDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAFNWPFLGPRQCIASETASLPMIVSIKEGGRTRPQVVSLPNMRVQKCSCASDGALVPRRLQP
uniprot
proteins
disease_involvement
DISEASE: Left-right axis malformations (LRAM) [MIM:601877]: The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava. {ECO:0000269|PubMed:10053005}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
uniprot
proteins
mass_dalton
40920
uniprot
proteins
post_translational_modification
PTM: The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
10053005
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
9153275
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins