Septin4
entrez
287606
canonical
uniprot
A0A096MJN4
canonical
ensembl
ENSRNOG00000007367
resolver
ensembl
ENSRNOG00055026508
resolver
ensembl
ENSRNOG00060030766
resolver
ensembl
ENSRNOG00065017412
resolver
ensp
ENSRNOP00000041380
resolver
ensp
ENSRNOP00000068198
resolver
ensp
ENSRNOP00000068282
resolver
ensp
ENSRNOP00000072349
resolver
ensp
ENSRNOP00000110392
resolver
ensp
ENSRNOP00055037843
resolver
ensp
ENSRNOP00060044743
resolver
ensp
ENSRNOP00065023272
resolver
enst
ENSRNOT00000044226
resolver
enst
ENSRNOT00000076026
resolver
enst
ENSRNOT00000076050
resolver
enst
ENSRNOT00055046116
resolver
enst
ENSRNOT00060053951
resolver
enst
ENSRNOT00065029326
resolver
genesymbol
Septin4
resolver
genesymbol_syn
Arts
resolver
genesymbol_syn
Bh5
resolver
genesymbol_syn
Gm11492
resolver
genesymbol_syn
Pnut12
resolver
genesymbol_syn
Sep4
resolver
genesymbol_syn
Sept4
resolver
uniprot
A0A096MJW0
resolver
uniprot
E9PST0
resolver
uniprot
Q6XUZ6
resolver
uniprot_entry
A0A096MJW0_RAT
resolver
uniprot_entry
E9PST0_RAT
resolver
uniprot_entry
Q6XUZ6_RAT
resolver
uniprot_entry
SEPT4_RAT
resolver
amino_acid_sequence
MIKHFLEDNSDDAELSKFVKDFPGSEPCHPTESKTRVARPQILEPRPQSPDLCDDDVEFRATLWSQPSDSQQYFCPPAPLSPSSRPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWRPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPSEVDRKKCKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQRQMKETH
uniprot
proteins
function
FUNCTION: Filament-forming cytoskeletal GTPase. Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP (By similarity). May also play a role in the regulation of cell fate in the intestine (By similarity). Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis; via its interaction with XIAP (By similarity). Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP (By similarity). Plays an important role in male fertility and sperm motility (By similarity). During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (By similarity). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Required for dopaminergic metabolism in presynaptic autoreceptors; potentially via activity as a presynaptic scaffold protein (By similarity). {ECO:0000250|UniProtKB:P28661}.
uniprot
proteins
mass_dalton
53083
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by DYRK1A. {ECO:0000250|UniProtKB:P28661}.
uniprot
proteins
protein_family
Septin GTPase family
uniprot
proteins
protein_family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
18938227
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P28661}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:P28661}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:O43236}. Cell projection, axon {ECO:0000250|UniProtKB:P28661}. Cell projection, dendrite {ECO:0000250|UniProtKB:P28661}. Perikaryon {ECO:0000250|UniProtKB:P28661}. Note=Found in the sperm annulus, a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum (By similarity). In platelets, found in areas surrounding alpha-granules (By similarity). Expressed and colocalized with SLC6A3 and SNCA in axon terminals, especially at the varicosities (By similarity). Expressed at the annulus in spermatozoa (By similarity). {ECO:0000250|UniProtKB:O43236, ECO:0000250|UniProtKB:P28661}.
uniprot
proteins