Dpyd
entrez
99586
canonical
uniprot
Q8CHR6
canonical
ensembl
ENSMUSG00000033308
resolver
ensp
ENSMUSP00000039429
resolver
ensp
ENSMUSP00000298426
resolver
enst
ENSMUST00000039177
resolver
genesymbol
Dpyd
resolver
uniprot_entry
DPYD_MOUSE
resolver
amino_acid_sequence
MAGVLSRDAPDIESILALNPRVQAHATLRSTAAKKLDKKHWKRNTDKNCFTCEKLESNFDDIKHTTLGERGALREAVRCLKCADAPCQKSCPTSLDIKSFITSIANKNYYGAAKLIFSDNPLGLTCGMVCPTSDLCVGGCNLHAAEEGPINIGGLQQFATEVFKAMNIPQIRNPSLPPPEHMPEAYSAKIALFGAGPASISCASFLARLGYSNITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSTDEMTLSSLKENGYRAAFIGIGLPEPKKDHIFQGLTQVQGFYTSKDFLPLVAKSSKTGMCACHSPLPSIRGAVIVLGAGDTAFDCATSALRCGALRVFIVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKDGKIVAMQFVRTEQDETGNWVEDEEQTVRLKADVVISAFGSVLEDPKVKEALSPIKFNRWGLPEVNPETMQTSEPWVFAGGDVVGMANTTVESVNDGKQASWYIHKHIQAQYGTSVPSQPTMPLFYTPVDLVDISVEMAGLRFPNPFGLASATPATSTPMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPLYGPGQSSFLNIELISEKTAAYWCHSVTELKADFPDNILIASIMCSYNKSDWMELSKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVRVPFFAKLTPNVTDIVSIARAAKEGGADGVTATNTVSGLMGLKADGTPWPAVGIGRRTTYGGVSGTAIRPIALRAVTAIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELADWDGQSPPIISHQKGKPVPRVAELMGQKLPSFGPYLEQRKKIIAASKIRQKDQNTACSPLQRKHFNSQKPIPAIKDVIGKSLQYLGTFGEMSIMEQVVALIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTVSDTCTGCTLCLSVCPIMDCIRMVSRATPYQPKRGLPLAVKPVC
uniprot
proteins
ec_number
1.3.1.2
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of uracil and thymine in the initial step of reductive pyrimidine catabolism, a pathway that yields beta-alanine from uracil and beta-aminoisobutyrate from thymine (By similarity). Also capable of degrading the chemotherapeutic drug 5-fluorouracil (By similarity). {ECO:0000250|UniProtKB:Q12882, ECO:0000250|UniProtKB:Q28943}.
uniprot
proteins
mass_dalton
111253
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; beta-alanine biosynthesis. {ECO:0000250|UniProtKB:Q12882}.
uniprot
proteins
protein_family
Dihydropyrimidine dehydrogenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1025
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O89000}.
uniprot
proteins