ECH1
entrez
1891
canonical
uniprot
Q13011
canonical
ensembl
ENSG00000104823
resolver
ensembl
ENSG00000282853
resolver
ensp
ENSP00000221418
resolver
ensp
ENSP00000489530
resolver
enst
ENST00000221418
resolver
enst
ENST00000634245
resolver
genesymbol
ECH1
resolver
hgnc
HGNC:3149
resolver
uniprot
A0A384MR44
resolver
uniprot
A8K745
resolver
uniprot
Q8WVX0
resolver
uniprot
Q96EZ9
resolver
uniprot_entry
A0A384MR44_HUMAN
resolver
uniprot_entry
ECH1_HUMAN
resolver
uniprot_sec
A8K745
resolver
uniprot_sec
Q8WVX0
resolver
uniprot_sec
Q96EZ9
resolver
amino_acid_sequence
MAAGIVASRRLRDLLTRRLTGSNYPGLSISLRLTGSSAQEEASGVALGEAPDHSYESLRVTSAQKHVLHVQLNRPNKRNAMNKVFWREMVECFNKISRDADCRAVVISGAGKMFTAGIDLMDMASDILQPKGDDVARISWYLRDIITRYQETFNVIERCPKPVIAAVHGGCIGGGVDLVTACDIRYCAQDAFFQVKEVDVGLAADVGTLQRLPKVIGNQSLVNELAFTARKMMADEALGSGLVSRVFPDKEVMLDAALALAAEISSKSPVAVQSTKVNLLYSRDHSVAESLNYVASWNMSMLQTQDLVKSVQATTENKELKTVTFSKL
uniprot
proteins
ec_number
5.3.3.21
uniprot
proteins
function
FUNCTION: Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids (PubMed:26474213). Together with the 2,4-dienoyl-CoA reductase (DECR) and the Enoyl-CoA delta isomerase 1 (ECI1) they allow reentrance of the enoyl-CoA into the beta-oxidation cycle (PubMed:26474213). Able to isomerize 3-trans,5-cis-dienoyl-CoA (3E,5Z-dienoyl-CoA) to 2-trans,4-trans-dienoyl-CoA (2E,4E-dienoyl-CoA), a crucial step in the beta-oxidation of unsaturated fatty acids with double bonds at odd position (By similarity) (PubMed:26474213). Based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally (Probable). {ECO:0000250|UniProtKB:Q62651, ECO:0000303|PubMed:26474213, ECO:0000305|PubMed:26474213}.
uniprot
proteins
mass_dalton
35816
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000250|UniProtKB:Q62651}.
uniprot
proteins
protein_family
Enoyl-CoA hydratase/isomerase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26474213
uniprot
proteins
pubmed
7558027
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q62651}. Peroxisome {ECO:0000250|UniProtKB:Q62651}.
uniprot
proteins