S1PR4
entrez
8698
canonical
uniprot
O95977
canonical
ensembl
ENSG00000125910
resolver
ensp
ENSP00000246115
resolver
enst
ENST00000246115
resolver
genesymbol
S1PR4
resolver
genesymbol_syn
EDG6
resolver
hgnc
HGNC:3170
resolver
uniprot
D6W612
resolver
uniprot_entry
S1PR4_HUMAN
resolver
uniprot_sec
D6W612
resolver
amino_acid_sequence
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
uniprot
proteins
function
FUNCTION: G protein-coupled receptor highly expressed in immune cells, where it regulates immune response and cytokine production. Functions as a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P). Upon S1P binding, promotes regulatory T-cell differentiation and enhances fatty acid oxidation, through activation of the NRF2/PPARA signaling pathway (By similarity). Modulates also M1 macrophage activation through interaction with FPR2 and the JNK signaling, contributing to the inflammatory response (By similarity). In addition, facilitates early neutrophil mobilization and vascular activation during inflammation, promoting lymphocyte recruitment to draining lymph nodes and supporting the development of germinal centers for an effective adaptive immune response (By similarity). {ECO:0000250|UniProtKB:Q9Z0L1, ECO:0000269|PubMed:10679247, ECO:0000269|PubMed:10753843}.
uniprot
proteins
mass_dalton
41623
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10679247
uniprot
proteins
pubmed
10753843
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17443712
uniprot
proteins
pubmed
9790765
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 51..71; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 85..105; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 118..138; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 162..182; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 207..227; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 253..273; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 289..309; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins