BTRC
entrez
8945
canonical
uniprot
Q9Y297
canonical
ensembl
ENSG00000166167
resolver
ensp
ENSP00000359206
resolver
ensp
ENSP00000377088
resolver
ensp
ENSP00000385339
resolver
ensp
ENSP00000531941
resolver
enst
ENST00000393441
resolver
genesymbol
BTRC
resolver
genesymbol_syn
BTRCP
resolver
genesymbol_syn
FBW1A
resolver
genesymbol_syn
FBXW1A
resolver
hgnc
HGNC:1144
resolver
uniprot
A0A0S2Z4P6
resolver
uniprot
B2R8L3
resolver
uniprot
B5MD49
resolver
uniprot
B7Z3H4
resolver
uniprot
F8WA68
resolver
uniprot
Q5W141
resolver
uniprot
Q5W142
resolver
uniprot
Q9Y213
resolver
uniprot_entry
A0A0S2Z4P6_HUMAN
resolver
uniprot_entry
B2R8L3_HUMAN
resolver
uniprot_entry
B7Z3H4_HUMAN
resolver
uniprot_entry
F8WA68_HUMAN
resolver
uniprot_entry
FBW1A_HUMAN
resolver
uniprot_sec
B5MD49
resolver
uniprot_sec
Q5W141
resolver
uniprot_sec
Q5W142
resolver
uniprot_sec
Q9Y213
resolver
amino_acid_sequence
MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTYTYISR
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11158290, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:22087322, PubMed:25503564, PubMed:25704143, PubMed:36608670, PubMed:9859996, PubMed:9990852). Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11158290, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:22087322, PubMed:25503564, PubMed:25704143, PubMed:36608670, PubMed:9859996, PubMed:9990852). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PubMed:12077367, PubMed:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PubMed:10835356, PubMed:11238952, PubMed:14603323, PubMed:14681206). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:9859996). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435). The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation (PubMed:10835356, PubMed:11158290, PubMed:14673179). SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564, PubMed:25704143). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. SCF(BTRC) acts as a negative regulator of smoothened signaling by mediating ubiquitination of GLI2 and GLI3 in absence of smoothened, promoting their processing into transcription repressors (PubMed:16705181, PubMed:16371461). Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (PubMed:18354482, PubMed:21258371). SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis (By similarity). SCF(BTRC) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF (PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:33110214, PubMed:36608670). SCF(BTRC) directs 'Lys-48'-linked ubiquitination of UBR2 in the T-cell receptor signaling pathway (PubMed:38225265). {ECO:0000250|UniProtKB:Q3ULA2, ECO:0000269|PubMed:10066435, ECO:0000269|PubMed:10497169, ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:10835356, ECO:0000269|PubMed:11158290, ECO:0000269|PubMed:11238952, ECO:0000269|PubMed:11359933, ECO:0000269|PubMed:11994270, ECO:0000269|PubMed:12077367, ECO:0000269|PubMed:12791267, ECO:0000269|PubMed:12820959, ECO:0000269|PubMed:12902344, ECO:0000269|PubMed:14603323, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988407, ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16371461, ECO:0000269|PubMed:16705181, ECO:0000269|PubMed:18354482, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:22087322, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:33110214, ECO:0000269|PubMed:38225265, ECO:0000269|PubMed:9859996, ECO:0000269|PubMed:9990852}.
uniprot
proteins
mass_dalton
68867
uniprot
proteins
mutagenesis
MUTAGEN 307; /note="Y->A: Abolished binding to TFE3 and MITF substrates."; /evidence="ECO:0000269|PubMed:36608670"; MUTAGEN 321; /note="R->A: Abolished binding to TFE3 and MITF substrates."; /evidence="ECO:0000269|PubMed:36608670"; MUTAGEN 510; /note="R->A: Abolished binding to DEPTOR, TFE3 and MITF substrates."; /evidence="ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:36608670
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:10835356, ECO:0000269|PubMed:11158290, ECO:0000269|PubMed:16371461, ECO:0000269|PubMed:16705181, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:9859996, ECO:0000269|PubMed:9990852}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated (PubMed:33110214). Deubiquitinated by OTUD5, promoting its stability (PubMed:33110214). {ECO:0000269|PubMed:33110214}.
uniprot
proteins
pubmed
10066435
uniprot
proteins
pubmed
10497169
uniprot
proteins
pubmed
10531035
uniprot
proteins
pubmed
10644755
uniprot
proteins
pubmed
10835356
uniprot
proteins
pubmed
10983987
uniprot
proteins
pubmed
11158290
uniprot
proteins
pubmed
11238952
uniprot
proteins
pubmed
11359933
uniprot
proteins
pubmed
11994270
uniprot
proteins
pubmed
12037680
uniprot
proteins
pubmed
12077367
uniprot
proteins
pubmed
12791267
uniprot
proteins
pubmed
12820959
uniprot
proteins
pubmed
12902344
uniprot
proteins
pubmed
14603323
uniprot
proteins
pubmed
14673179
uniprot
proteins
pubmed
14681206
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14988407
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15448698
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15647282
uniprot
proteins
pubmed
15917222
uniprot
proteins
pubmed
16371461
uniprot
proteins
pubmed
16705181
uniprot
proteins
pubmed
17079684
uniprot
proteins
pubmed
17574027
uniprot
proteins
pubmed
18354482
uniprot
proteins
pubmed
18794143
uniprot
proteins
pubmed
20068069
uniprot
proteins
pubmed
20736409
uniprot
proteins
pubmed
21258371
uniprot
proteins
pubmed
22017875
uniprot
proteins
pubmed
22017876
uniprot
proteins
pubmed
22017877
uniprot
proteins
pubmed
22087322
uniprot
proteins
pubmed
23468625
uniprot
proteins
pubmed
25503564
uniprot
proteins
pubmed
25704143
uniprot
proteins
pubmed
29420262
uniprot
proteins
pubmed
33110214
uniprot
proteins
pubmed
36608670
uniprot
proteins
pubmed
38225265
uniprot
proteins
pubmed
9660940
uniprot
proteins
pubmed
9859996
uniprot
proteins
pubmed
9990852
uniprot
proteins
sequence_length
605
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3ULA2}. Nucleus {ECO:0000250|UniProtKB:Q3ULA2}.
uniprot
proteins