Pdgfc
entrez
54635
canonical
uniprot
Q8CI19
canonical
ensembl
ENSMUSG00000028019
resolver
ensp
ENSMUSP00000029652
resolver
enst
ENSMUST00000029652
resolver
genesymbol
Pdgfc
resolver
genesymbol_syn
Scdgf
resolver
uniprot
Q99JM4
resolver
uniprot
Q9JHV8
resolver
uniprot
Q9QY71
resolver
uniprot_entry
PDGFC_MOUSE
resolver
uniprot_sec
Q99JM4
resolver
uniprot_sec
Q9JHV8
resolver
uniprot_sec
Q9QY71
resolver
amino_acid_sequence
MLLLGLLLLTSALAGQRTGTRAESNLSSKLQLSSDKEQNGVQDPRHERVVTISGNGSIHSPKFPHTYPRNMVLVWRLVAVDENVRIQLTFDERFGLEDPEDDICKYDFVEVEEPSDGSVLGRWCGSGTVPGKQTSKGNHIRIRFVSDEYFPSEPGFCIHYSIIMPQVTETTSPSVLPPSSLSLDLLNNAVTAFSTLEELIRYLEPDRWQVDLDSLYKPTWQLLGKAFLYGKKSKVVNLNLLKEEVKLYSCTPRNFSVSIREELKRTDTIFWPGCLLVKRCGGNCACCLHNCNECQCVPRKVTKKYHEVLQLRPKTGVKGLHKSLTDVALEHHEECDCVCRGNAGG
uniprot
proteins
disease_involvement
DISEASE: Note=Involved in the development of myocarditis and subsequent fibrosis in the experimental model of coxsackievirus B3-induced chronic myocarditis. {ECO:0000269|PubMed:15757957}.
uniprot
proteins
function
FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. {ECO:0000269|PubMed:10806482, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12875986, ECO:0000269|PubMed:12972405, ECO:0000269|PubMed:15361870, ECO:0000269|PubMed:15372073, ECO:0000269|PubMed:15757957, ECO:0000269|PubMed:18184860}.
uniprot
proteins
mass_dalton
38741
uniprot
proteins
post_translational_modification
PTM: Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG (By similarity). {ECO:0000250}.; PTM: Sumoylated by SUMO1. {ECO:0000269|PubMed:16443219}.; PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
PDGF/VEGF growth factor family
uniprot
proteins
pubmed
10806482
uniprot
proteins
pubmed
10960785
uniprot
proteins
pubmed
11297552
uniprot
proteins
pubmed
11313995
uniprot
proteins
pubmed
11744381
uniprot
proteins
pubmed
12875986
uniprot
proteins
pubmed
12972405
uniprot
proteins
pubmed
15061151
uniprot
proteins
pubmed
15207812
uniprot
proteins
pubmed
15361870
uniprot
proteins
pubmed
15372073
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15757957
uniprot
proteins
pubmed
15911618
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16344272
uniprot
proteins
pubmed
16443219
uniprot
proteins
pubmed
16951379
uniprot
proteins
pubmed
17066417
uniprot
proteins
pubmed
18184860
uniprot
proteins
sequence_length
345
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16443219}. Secreted {ECO:0000269|PubMed:15372073}. Nucleus {ECO:0000250|UniProtKB:Q9NRA1}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q9NRA1}. Cell membrane {ECO:0000269|PubMed:16443219}. Note=Sumoylated form is predominant in the nucleus (PubMed:16443219). Stored in alpha granules in platelets (By similarity). {ECO:0000250|UniProtKB:Q9NRA1, ECO:0000269|PubMed:16443219}.
uniprot
proteins