Kremen1
entrez
84035
canonical
uniprot
Q99N43
canonical
ensembl
ENSMUSG00000020393
resolver
ensp
ENSMUSP00000020662
resolver
ensp
ENSMUSP00000280235
resolver
ensp
ENSMUSP00000280247
resolver
enst
ENSMUST00000020662
resolver
genesymbol
Kremen1
resolver
genesymbol_syn
Kremen
resolver
uniprot
Q640Q6
resolver
uniprot_entry
KREM1_MOUSE
resolver
uniprot_sec
Q640Q6
resolver
amino_acid_sequence
MAPPAARLALLSAAALTLAARPAPGPRSGPECFTANGADYRGTQSWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPGNLGCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKHGEAASTECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMAAVVYSPDFPDTYATGRVCYWTIRVPGASRIHFNFTLFDIRDSADMVELLDGYTHRVLVRLSGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQATKEEPPQERPAVNQTLAEVITEQANLSVSAAHSSKVLYVITPSPSHPPQTAPGSHSWAPSVGANSHRVEGWTVYGLATLLILTVTAVVAKILLHVTFKSHRVPASGDLRDCRQPGASGDIWTIFYEPSTTISIFKKKLKGQSQQDDRNPLVSD
uniprot
proteins
function
FUNCTION: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6 (PubMed:12050670). In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane (By similarity). Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1 (PubMed:26206087). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation (PubMed:18505822). Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification (PubMed:27550540). {ECO:0000250|UniProtKB:Q90Y90, ECO:0000269|PubMed:12050670, ECO:0000269|PubMed:18505822, ECO:0000269|PubMed:26206087, ECO:0000269|PubMed:27550540}.
uniprot
proteins
mass_dalton
51673
uniprot
proteins
mutagenesis
MUTAGEN 419; /note="S->F: Significant reduction of apoptotic activity."; /evidence="ECO:0000269|PubMed:26206087"; MUTAGEN 437; /note="S->L: Significant reduction of apoptotic activity."; /evidence="ECO:0000269|PubMed:26206087"; MUTAGEN 453; /note="I->V: Significant reduction of apoptotic activity."; /evidence="ECO:0000269|PubMed:26206087"; MUTAGEN 472; /note="S->G: Complete loss of apoptotic activity."; /evidence="ECO:0000269|PubMed:26206087"; MUTAGEN 473; /note="D->N: Complete loss of apoptotic activity."; /evidence="ECO:0000269|PubMed:26206087
uniprot
proteins
pubmed
11267660
uniprot
proteins
pubmed
12050670
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18505822
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26206087
uniprot
proteins
pubmed
27550540
uniprot
proteins
sequence_length
473
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27550540}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 393..413; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins