Rlig1
entrez
314788
canonical
uniprot
Q6AXM9
canonical
ensembl
ENSRNOG00000006973
resolver
ensp
ENSRNOP00000071985
resolver
ensp
ENSRNOP00000092322
resolver
ensp
ENSRNOP00000105940
resolver
enst
ENSRNOT00000158247
resolver
genesymbol
Rlig1
resolver
uniprot
A0ABK0LW53
resolver
uniprot_entry
A0ABK0LW53_RAT
resolver
uniprot_entry
RLIG1_RAT
resolver
amino_acid_sequence
MNRLGSVQRKMPCVFVTEVKAEPSAKREHQPFKVLATETLSEKALDADVYNAVATEKVDGTCCYVTNYKGQPYLWARLDRKPNKQADKRFKKFLHSKENAKEFHWNTEEDFKPVPECWIPAKEIEKQNGKPVPDENGHIPGWVPVEKNSKQYCWHSSVVSYEFGIALVLRHHPDDPGVLEISAVPLSELLEQTLELIGTNINGNPYGLGSKKYPLHFLTPHGAFQVRNLPTLKHNDLLSWFEGCREGQIEGIVWHCGDGCLIKVHRHHLGLCWPLPDTYMNSKPVIINMNLDKYDCAFDHQSLFNKFSKIDKQKFDRLKDITLDI
uniprot
proteins
ec_number
6.5.1.3
uniprot
proteins
function
FUNCTION: Functions as an RNA ligase, in vitro. The ligation reaction entails three nucleotidyl transfer steps. In the first step, the RNA ligase reacts with ATP in the absence of nucleic acid to form a covalent ligase-AMP intermediate and release pyrophosphate. In step 2, the ligase-AMP binds to the nucleic acid and transfers the adenylate to the 5'-PO4 terminus to form an adenylylated intermediate. In step 3, the RNA ligase directs the attack of the 3'-OH on the 5'-phosphoanhydride linkage, resulting in a repaired 3'-5' phosphodiester and release of AMP. Exhibits selectivity for single-stranded RNA substrates and may not have nick-sealing activity on double-stranded DNA-RNA hybrids. May play a role in maintaining RNA integrity under stress conditions, for example in response to reactive oxygen species (ROS). {ECO:0000250|UniProtKB:Q8N999}.
uniprot
proteins
mass_dalton
37305
uniprot
proteins
post_translational_modification
PTM: AMPylates itself (auto-AMPylation). {ECO:0000250|UniProtKB:Q8N999}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
325
uniprot
proteins