IL11
entrez
3589
canonical
uniprot
P20809
canonical
ensembl
ENSG00000095752
resolver
ensp
ENSP00000264563
resolver
ensp
ENSP00000465705
resolver
genesymbol
IL11
resolver
hgnc
HGNC:5966
resolver
uniprot
A8K3F7
resolver
uniprot
B4DQV5
resolver
uniprot
Q96EB4
resolver
uniprot_entry
A8K3F7_HUMAN
resolver
uniprot_entry
IL11_HUMAN
resolver
uniprot_sec
B4DQV5
resolver
uniprot_sec
Q96EB4
resolver
amino_acid_sequence
MNCVCRLVLVVLSLWPDTAVAPGPPPGPPRVSPDPRAELDSTVLLTRSLLADTRQLAAQLRDKFPADGDHNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLKTLEPELGTLQARLDRLLRRLQLLMSRLALPQPPPDPPAPPLAPPSSAWGGIRAAHAILGGLHLTLDWAVRGLLLLKTRL
uniprot
proteins
function
FUNCTION: Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168). {ECO:0000250|UniProtKB:P47873, ECO:0000269|PubMed:12919066, ECO:0000269|PubMed:2145578, ECO:0000269|PubMed:30279168}.
uniprot
proteins
mass_dalton
21429
uniprot
proteins
mutagenesis
MUTAGEN 182; /note="H->V: Increases affinity for IL11RA and stimulation of cell proliferation."; /evidence="ECO:0000269|PubMed:12919066"; MUTAGEN 186; /note="D->A: Strongly increases affinity for IL11RA and stimulation of cell proliferation."; /evidence="ECO:0000269|PubMed:12919066"; MUTAGEN 186; /note="D->V: Increases affinity for IL11RA and stimulation of cell proliferation."; /evidence="ECO:0000269|PubMed:12919066
uniprot
proteins
protein_family
IL-6 superfamily
uniprot
proteins
pubmed
12919066
uniprot
proteins
pubmed
1386338
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1828438
uniprot
proteins
pubmed
2145578
uniprot
proteins
pubmed
25195742
uniprot
proteins
pubmed
30279168
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1828438, ECO:0000269|PubMed:2145578}.
uniprot
proteins