RAB40A
entrez
142684
canonical
uniprot
Q8WXH6
canonical
ensembl
ENSG00000172476
resolver
ensp
ENSP00000305648
resolver
ensp
ENSP00000361716
resolver
ensp
ENSP00000575360
resolver
ensp
ENSP00000575361
resolver
ensp
ENSP00000612618
resolver
ensp
ENSP00000612619
resolver
enst
ENST00000304236
resolver
enst
ENST00000372633
resolver
enst
ENST00000905301
resolver
enst
ENST00000905302
resolver
enst
ENST00000942559
resolver
enst
ENST00000942560
resolver
genesymbol
RAB40A
resolver
hgnc
HGNC:18283
resolver
uniprot
O00407
resolver
uniprot
Q17RQ5
resolver
uniprot
Q6DK06
resolver
uniprot
Q8TF06
resolver
uniprot_entry
RB40A_HUMAN
resolver
uniprot_sec
O00407
resolver
uniprot_sec
Q17RQ5
resolver
uniprot_sec
Q6DK06
resolver
uniprot_sec
Q8TF06
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:P62820}.
uniprot
proteins
amino_acid_sequence
MSAPGSPDQAYDFLLKFLLVGDRDVGKSEILESLQDGAAESPYSHLGGIDYKTTTILLDGQRVKLKLWDTSGQGRFCTIFRSYSRGAQGVILVYDIANRWSFEGMDRWIKKIEEHAPGVPKILVGNRLHLAFKRQVPREQAQAYAERLGVTFFEVSPLCNFNIIESFTELARIVLLRHRMNWLGRPSKVLSLQDLCCRTIVSCTPVHLVDKLPLPSTLRSHLKSFSMAKGLNARMMRGLSYSLTTSSTHKSSLCKVEIVCPPQSPPKNCTRNSCKIS
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: RAB40A small GTPase acts as substrate-recognition component of the ECS(RAB40A) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:26598620). The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). As part of the ECS(RAB40A) complex, mediates RHOU 'Lys-48'-linked ubiquitination and degradation, thus inhibiting focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000250|UniProtKB:Q96S21, ECO:0000269|PubMed:26598620}.
uniprot
proteins
mass_dalton
31076
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16923123
uniprot
proteins
pubmed
26598620
uniprot
proteins
sequence_length
277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
uniprot
proteins