Slc10a6
entrez
75750
canonical
uniprot
Q9CXB2
canonical
ensembl
ENSMUSG00000029321
resolver
ensp
ENSMUSP00000031263
resolver
enst
ENSMUST00000031263
resolver
genesymbol
Slc10a6
resolver
genesymbol_syn
Soat
resolver
uniprot
B2RTH4
resolver
uniprot_entry
SOAT_MOUSE
resolver
uniprot_sec
B2RTH4
resolver
amino_acid_sequence
MSTDCAGNSTCPVNSTEEDPPVGMEGHANLKLLFTVLSAVMVGLVMFSFGCSVESQKLWLHLRRPWGIAVGLLSQFGLMPLTAYLLAIGFGLKPFQAIAVLMMGSCPGGTISNVLTFWVDGDMDLSISMTTCSTVAALGMMPLCLYIYTRSWTLTQNLVIPYQSIGITLVSLVVPVASGVYVNYRWPKQATVILKVGAILGGMLLLVVAVTGMVLAKGWNTDVTLLVISCIFPLVGHVTGFLLAFLTHQSWQRCRTISIETGAQNIQLCIAMLQLSFSAEYLVQLLNFALAYGLFQVLHGLLIVAAYQAYKRRQKSKCRRQHPDCPDVCYEKQPRETSAFLDKGDEAAVTLGPVQPEQHHRAAELTSHIPSCE
uniprot
proteins
function
FUNCTION: Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis (PubMed:23562556). Steroid sulfate hormones are commonly considered to be biologically inactive metabolites, that may be activated by steroid sulfatases into free steroids (By similarity). May play an important role by delivering sulfoconjugated steroids to specific target cells in reproductive organs (PubMed:23562556). May play a role transporting the estriol precursor 16alpha-hydroxydehydroepiandrosterone 3-sulfate (16a-OH-DHEAS) at the fetal blood vessel endothelium (By similarity). Can also transport other sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes (By similarity). {ECO:0000250|UniProtKB:Q3KNW5, ECO:0000269|PubMed:23562556}.
uniprot
proteins
mass_dalton
40681
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
Bile acid:sodium symporter (BASS) (TC 2.A.28) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23562556
uniprot
proteins
pubmed
28743544
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:23562556}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..53; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 68..88; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 98..118; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 266..283; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 285..305; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins