Pitpnm2
entrez
19679
canonical
uniprot
Q6ZPQ6
canonical
ensembl
ENSMUSG00000029406
resolver
ensp
ENSMUSP00000124111
resolver
ensp
ENSMUSP00000124292
resolver
ensp
ENSMUSP00000124740
resolver
ensp
ENSMUSP00000143269
resolver
ensp
ENSMUSP00000224772
resolver
ensp
ENSMUSP00000224777
resolver
ensp
ENSMUSP00000224783
resolver
ensp
ENSMUSP00000224787
resolver
ensp
ENSMUSP00000224788
resolver
ensp
ENSMUSP00000224793
resolver
ensp
ENSMUSP00000224800
resolver
enst
ENSMUST00000159677
resolver
enst
ENSMUST00000161273
resolver
genesymbol
Pitpnm2
resolver
genesymbol_syn
Kiaa1457
resolver
genesymbol_syn
Nir3
resolver
uniprot
A0A0G2JFQ8
resolver
uniprot
E9PYJ7
resolver
uniprot
Q6NS55
resolver
uniprot
Q9R1P5
resolver
uniprot_entry
A0A0G2JFQ8_MOUSE
resolver
uniprot_entry
E9PYJ7_MOUSE
resolver
uniprot_entry
PITM2_MOUSE
resolver
uniprot_entry
Q6NS55_MOUSE
resolver
uniprot_sec
Q9R1P5
resolver
amino_acid_sequence
MIIKEYRIPLPMTVDEYRIAQLYMIQKKSRNETHGQGSGVEILENRPYTDGPGGSGQYTHKVYHVGMHIPGWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDTGENNNVFNLSPVEKSQLITDIIDIVKDPVPPSEYKTEEDPKLFQSVKTCRGPLSENWIQEYKKRLLPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWYGLTMEKIRELEREVQLMLSRKMAQFSEEGPSELSKDSATKDQASGTTSDPGSKNGEPLGRGLKKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDSDEGSEEEFFDAHENLYCTEEKQAKDMTKWNSNDLMDKMESPEPEESQDEIYQQSGSEFRVASSVEQLNIIEDEVSQPLAAPPSKIHVLLLVLHGGTILDTGAGDPSSKQGDTNTITNVFDTVMRVHYPSALGHLAIRLVPCPPICADAFALVSNLSPYGHDEGCLSSSQDHIPLAALPLLATSSPQYQEAVATVIQRANLAYGDFIKSQEGVTFNGQVCLIGDCVGGILAFDALCYSGQPVSESQSSSRRGSVVSMQDADLLSPGTLANAAHCSGGSGGGGSGGSSLESSRHLSRSNIDIPRSNGTEDSRRQLPRKRSDSSTYELDTIQQHQAFLSSLHASVLRNEPSSRRSSSSTMLDGAGALGKFDFEIADLFLFGCPLGLVLALRKTVIPSLDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHSLPPFSIPRYQRYPLGDGCSTLLADVLQTHNTVFQEHAAPSSPGTAPAGRGFRRASEISIASQVSGMAESYTASSIAQKGPSSLNHTPSIRRLSLLALPPPSPTTQGPRARARQVSPNLERAPCLPDLDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDSSSILELDGKEVSVFTPSQPRERWQRKRTHVKLRNVAANHRINDAVANEDGPQVVTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLHLDTLVTNSSGRVSYTIPETHRLGVGVYPIKMVVRGDHTFADSYITVLPRGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRAHAAYGSTKDVAVYNSISLSPMHIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYNHRARPARNTATRMALRKGSFGLPGQSDFLRSRNHLLRTISAQPSGPSHRHDRTQTQMDSEQRGQRSMSVAASCWGRAMAGRLEPGAATGPK
uniprot
proteins
function
FUNCTION: Membrane-associated phosphatidylinositol (PI) transfer protein that shuttles PI between intracellular membranes and thereby maintains plasma membrane phosphoinositide signaling competence (PubMed:36581712). Upon production of phosphatidic acid (PA), mediates the transfer of phosphatidylinositol from the endoplasmic reticulum to the plasma membrane at endoplasmic reticulum-plasma membrane contact sites. This transfer sustains phospholipase C (PLC)-coupled receptor signaling and replenishing of plasma membrane phosphoinositides following receptor-induced hydrolysis (PubMed:36581712). Promotes PIP2 replenishment following TCR stimulation; plays a critical role in T cell development by supporting calcium signaling in response to weak TCR stimulation during TCRbeta selection and positive selection of thymocytes, as well as maintaining peripheral T cell survival (PubMed:36581712). {ECO:0000269|PubMed:36581712}.
uniprot
proteins
mass_dalton
148035
uniprot
proteins
protein_family
PI transfer class IIA subfamily
uniprot
proteins
protein_family
PtdIns transfer protein family
uniprot
proteins
pubmed
10460238
uniprot
proteins
pubmed
12522145
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
36581712
uniprot
proteins
sequence_length
1335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10460238}; Peripheral membrane protein {ECO:0000269|PubMed:10460238}; Cytoplasmic side {ECO:0000269|PubMed:10460238}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BZ72}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BZ72}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9BZ72}. Note=Upon PIP2 hydrolysis, translocates to endoplasmic reticulum-plasma membrane contact sites. {ECO:0000250|UniProtKB:Q9BZ72}.
uniprot
proteins