POLR3C
entrez
10623
canonical
uniprot
Q9BUI4
canonical
ensembl
ENSG00000186141
resolver
ensp
ENSP00000334564
resolver
ensp
ENSP00000513913
resolver
ensp
ENSP00000513915
resolver
ensp
ENSP00000513918
resolver
ensp
ENSP00000640382
resolver
ensp
ENSP00000715621
resolver
ensp
ENSP00000758358
resolver
enst
ENST00000334163
resolver
enst
ENST00000698751
resolver
enst
ENST00000970323
resolver
genesymbol
POLR3C
resolver
hgnc
HGNC:30076
resolver
uniprot
O15317
resolver
uniprot
Q9Y3R6
resolver
uniprot_entry
RPC3_HUMAN
resolver
uniprot_sec
O15317
resolver
uniprot_sec
Q9Y3R6
resolver
amino_acid_sequence
MTQAEIKLCSLLLQEHFGEIVEKIGVHLIRTGSQPLRVIAHDTGTSLDQVKKALCVLVQHNLVSYQVHKRGVVEYEAQCSRVLRMLRYPRYIYTTKTLYSDTGELIVEELLLNGKLTMSAVVKKVADRLTETMEDGKTMDYAEVSNTFVRLADTHFVQRCPSVPTTENSDPGPPPPAPTLVINEKDMYLVPKLSLIGKGKRRRSSDEDAAGEPKAKRPKYTTDNKEPIPDDGIYWQANLDRFHQHFRDQAIVSAVANRMDQTSSEIVRTMLRMSEITTSSSAPFTQPLSSNEIFRSLPVGYNISKQVLDQYLTLLADDPLEFVGKSGDSGGGMYVINLHKALASLATATLESVVQERFGSRCARIFRLVLQKKHIEQKQVEDFAMIPAKEAKDMLYKMLSENFMSLQEIPKTPDHAPSRTFYLYTVNILSAARMLLHRCYKSIANLIERRQFETKENKRLLEKSQRVEAIIASMQATGAEEAQLQEIEEMITAPERQQLETLKRNVNKLDASEIQVDETIFLLESYIECTMKRQ
uniprot
proteins
function
FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:33558766, PubMed:34675218, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (PubMed:20413673, PubMed:33558764, PubMed:33558766, PubMed:35637192). Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer, coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state (PubMed:33558764, PubMed:33558766). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (PubMed:21358628). {ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:21358628, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:34675218, ECO:0000269|PubMed:35637192}.
uniprot
proteins
mass_dalton
60612
uniprot
proteins
mutagenesis
MUTAGEN 51..52; /note="KK->EE: Strongly decreased ssDNA-binding. No effect on interaction with POLR3F, POLR3G, nor with POLR3GL."; /evidence="ECO:0000269|PubMed:21358628"; MUTAGEN 312; /note="L->K: Loss of interaction with POLR3G and POLR3GL. No effect on interaction with POLR3F."; /evidence="ECO:0000269|PubMed:21358628"; MUTAGEN 357; /note="R->E: Strongly decreased ssDNA-binding. No effect on interaction with POLR3F, POLR3G, nor with POLR3GL."; /evidence="ECO:0000269|PubMed:21358628"; MUTAGEN 364..367; /note="RIFR->EIFE: Strongly decreased ssDNA-binding. No effect on interaction with POLR3F, POLR3G, nor with POLR3GL."; /evidence="ECO:0000269|PubMed:21358628"; MUTAGEN 389; /note="K->E: Strongly decreased ssDNA-binding. No effect on interaction with POLR3F, POLR3G, nor with POLR3GL."; /evidence="ECO:0000269|PubMed:21358628"; MUTAGEN 445..449; /note="NLIER->ALIEE: Strongly decreased ssDNA-binding. No effect on interaction with POLR3F, POLR3G, nor with POLR3GL."; /evidence="ECO:0000269|PubMed:21358628"; MUTAGEN 466..470; /note="RVEAI->EVEAF: Mild decrease in ssDNA-binding. No effect on interaction with POLR3F, POLR3G, nor with POLR3GL."; /evidence="ECO:0000269|PubMed:21358628
uniprot
proteins
protein_family
Eukaryotic RPC3/POLR3C RNA polymerase subunit family
uniprot
proteins
pubmed
10523658
uniprot
proteins
pubmed
11416169
uniprot
proteins
pubmed
12384934
uniprot
proteins
pubmed
12391170
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19609254
uniprot
proteins
pubmed
19631370
uniprot
proteins
pubmed
20413673
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21358628
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
24107381
uniprot
proteins
pubmed
26394183
uniprot
proteins
pubmed
33335104
uniprot
proteins
pubmed
33558764
uniprot
proteins
pubmed
33558766
uniprot
proteins
pubmed
33674783
uniprot
proteins
pubmed
34675218
uniprot
proteins
pubmed
35637192
uniprot
proteins
pubmed
9171375
uniprot
proteins
sequence_length
534
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33335104}.
uniprot
proteins