Ccr4
entrez
12773
canonical
uniprot
P51680
canonical
ensembl
ENSMUSG00000047898
resolver
ensp
ENSMUSP00000062677
resolver
ensp
ENSMUSP00000150002
resolver
enst
ENSMUST00000054414
resolver
enst
ENSMUST00000215425
resolver
genesymbol
Ccr4
resolver
genesymbol_syn
Cmkbr4
resolver
uniprot
Q14A03
resolver
uniprot_entry
CCR4_MOUSE
resolver
uniprot_sec
Q14A03
resolver
amino_acid_sequence
MNATEVTDTTQDETVYNSYYFYESMPKPCTKEGIKAFGEVFLPPLYSLVFLLGLFGNSVVVLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQWVFGLGLCKIVSWMYLVGFYSGIFFIMLMSIDRYLAIVHAVFSLKARTLTYGVITSLITWSVAVFASLPGLLFSTCYTEHNHTYCKTQYSVNSTTWKVLSSLEINVLGLLIPLGIMLFCYSMIIRTLQHCKNEKKNRAVRMIFAVVVLFLGFWTPYNVVLFLETLVELEVLQDCTLERYLDYAIQATETLAFIHCCLNPVIYFFLGEKFRKYITQLFRTCRGPLVLCKHCDFLQVYSADMSSSSYTQSTVDHDFRDAL
uniprot
proteins
function
FUNCTION: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival. {ECO:0000269|PubMed:10811868}.
uniprot
proteins
mass_dalton
41408
uniprot
proteins
post_translational_modification
PTM: In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10811868
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8573157
uniprot
proteins
pubmed
9192769
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 40..67; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 78..98; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 112..133; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 151..175; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 207..226; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 243..267; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 285..308; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins