Cox6b2
entrez
654441
canonical
uniprot
Q6YFQ1
canonical
ensembl
ENSRNOG00000077802
resolver
ensembl
ENSRNOG00055014369
resolver
ensembl
ENSRNOG00060026369
resolver
ensp
ENSRNOP00000107965
resolver
ensp
ENSRNOP00055020138
resolver
ensp
ENSRNOP00060037910
resolver
enst
ENSRNOT00000127328
resolver
enst
ENSRNOT00055024655
resolver
enst
ENSRNOT00060045685
resolver
genesymbol
Cox6b2
resolver
uniprot_entry
CX6B2_RAT
resolver
amino_acid_sequence
MLGVQAQMPAPGQWTTPPFDPRFPNQNQTRNCYQNFLDYHRCVKTMDRRGKNTQACDYYFRVFHSLCPVSWVQRWNEQIKQGTFPGKI
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:Q01519}.
uniprot
proteins
mass_dalton
10472
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:Q01519}.
uniprot
proteins
protein_family
Cytochrome c oxidase subunit 6B family
uniprot
proteins
pubmed
12874793
uniprot
proteins
sequence_length
88
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00429}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00429}; Intermembrane side {ECO:0000250|UniProtKB:P00429}.
uniprot
proteins