F1LX07
uniprot
F1LX07
canonical
activity_regulation
ACTIVITY REGULATION: L-aspartate and 3-sulfino-L-alanine uptake are both inhibited by glisoxepide. {ECO:0000269|PubMed:486467}.
uniprot
proteins
amino_acid_sequence
MAVKVHTTKRGDPHELRNIFLQYASTEVDGEHYMTPEDFVQRYLGLYNDPNSNPKIVQLLAGVADQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTIIHHHIPFNWDCEFIRLHFGHNRKKHLNYVEFTQFLQELQLEHARQAFALKDKSKSGMISGLDFSDVMVTIRSHMLTPFVEENLVSAAGGSTSHQVSFSYFNAFNSLLNNMELVRKIYSTLAGTRKDIEVTKEEFASAITYGVVTPINVGILYFINNVHISTGRLTLADIERIAPLAEGALPYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGTGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSIPLPAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLQDLGLFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGINLLTAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWFYIDFGGLKPSGSEPTPKSRIADLPPANPDHIGGYRLATATFAGIENKFGLYLPKFKSPGVAAAQPKVAAAAQ
uniprot
proteins
function
FUNCTION: Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:4436323). Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton (PubMed:486467). Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:486467). Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA) (By similarity). {ECO:0000250|UniProtKB:O75746, ECO:0000269|PubMed:4436323, ECO:0000269|PubMed:486467}.
uniprot
proteins
mass_dalton
74361
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
4436323
uniprot
proteins
pubmed
486467
uniprot
proteins
sequence_length
676
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:4436323, ECO:0000305|PubMed:486467}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 329..346; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O75746"; TRANSMEM 390..409; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O75746"; TRANSMEM 433..446; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O75746"; TRANSMEM 482..501; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O75746"; TRANSMEM 521..538; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O75746"; TRANSMEM 578..597; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O75746
uniprot
proteins