Abcd3
entrez
19299
canonical
uniprot
P55096
canonical
ensembl
ENSMUSG00000028127
resolver
ensp
ENSMUSP00000029770
resolver
ensp
ENSMUSP00000142387
resolver
ensp
ENSMUSP00000308542
resolver
ensp
ENSMUSP00000308543
resolver
enst
ENSMUST00000029770
resolver
enst
ENSMUST00000197383
resolver
genesymbol
Abcd3
resolver
genesymbol_syn
Pmp70
resolver
genesymbol_syn
Pxmp1
resolver
uniprot
A0A0G2JDI9
resolver
uniprot_entry
A0A0G2JDI9_MOUSE
resolver
uniprot_entry
ABCD3_MOUSE
resolver
amino_acid_sequence
MAAFSKYLTARNTSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFLSRLSQILKIMVPRTFCKETGYLLLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSSKDFKRYLFNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTRYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLLVSGLFLTRLRRPIGKMTIMEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTIHSVFRKLVEHLHNFIFFRFSMGFIDSIIAKYVATVVGYLVVSRPFLDLAHPRHLHSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGRYERTMVSQQEKGIEGAQASPLVPGAGEIINTDNIIKFDHVPLATPNGDILIQDLSFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGKEDQKKRGISDQVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKKITEDTVEFGS
uniprot
proteins
ec_number
3.1.2.-
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long- and very-long-chain fatty acyl-CoAs and probably bile acyl-CoAs from the cytosol to the peroxisome matrix for beta-oxydation. Appears to be specifically involved in the peroxisomal transport of branched-chain fatty acyl-CoAs (BCFA-CoAs) and dicarboxylic acyl CoAs (DCA-CoAs) (By similarity) (PubMed:25168382). Has fatty acyl-CoA thioesterase and ATPase activities. Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). {ECO:0000250|UniProtKB:P28288, ECO:0000269|PubMed:25168382}.
uniprot
proteins
mass_dalton
75475
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation. {ECO:0000250|UniProtKB:P28288}.; PATHWAY: Lipid metabolism; branched-chain fatty acid metabolism. {ECO:0000250|UniProtKB:P28288}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by PEX2 during pexophagy in response to starvation, leading to its degradation. {ECO:0000250|UniProtKB:P28288}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCD family
uniprot
proteins
protein_family
Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily
uniprot
proteins
pubmed
17208939
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
25168382
uniprot
proteins
pubmed
7544098
uniprot
proteins
pubmed
7551822
uniprot
proteins
sequence_length
659
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250|UniProtKB:P28288}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P28288}.
uniprot
proteins
transmembrane_region
TRANSMEM 83..103; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P28288"; TRANSMEM 128..149; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P28288"; TRANSMEM 199..218; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P28288"; TRANSMEM 232..248; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P28288"; TRANSMEM 307..328; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P28288"; TRANSMEM 363..382; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P28288
uniprot
proteins