DCC
entrez
1630
canonical
uniprot
P43146
canonical
ensembl
ENSG00000187323
resolver
ensp
ENSP00000389140
resolver
ensp
ENSP00000464582
resolver
enst
ENST00000442544
resolver
genesymbol
DCC
resolver
genesymbol_syn
IGDCC1
resolver
hgnc
HGNC:2701
resolver
uniprot
Q49AK4
resolver
uniprot_entry
DCC_HUMAN
resolver
uniprot_entry
Q49AK4_HUMAN
resolver
amino_acid_sequence
MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQLNAITGSAF
uniprot
proteins
disease_involvement
DISEASE: Mirror movements 1 (MRMV1) [MIM:157600]: A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. Some MRMV1 patients have agenesis of the corpus callosum. {ECO:0000269|PubMed:20431009, ECO:0000269|PubMed:28250454, ECO:0000269|PubMed:38314870}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Gaze palsy, familial horizontal, with progressive scoliosis, 2, with impaired intellectual development (HGPPS2) [MIM:617542]: An autosomal recessive neurologic disorder characterized by global developmental delay, delayed walking, intellectual disability, horizontal gaze palsy, and childhood-onset progressive scoliosis. {ECO:0000269|PubMed:28250456}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. {ECO:0000269|PubMed:8187090, ECO:0000269|PubMed:8861902}.
uniprot
proteins
mass_dalton
158457
uniprot
proteins
mutagenesis
MUTAGEN 1432; /note="L->S: Abolishes interaction with MYO10."; /evidence="ECO:0000269|PubMed:21642953"; MUTAGEN 1435..1436; /note="LM->SS: Abolishes interaction with MYO10."; /evidence="ECO:0000269|PubMed:21642953"; MUTAGEN 1439; /note="L->S: Abolishes interaction with MYO10."; /evidence="ECO:0000269|PubMed:21642953
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. {ECO:0000269|PubMed:9334332}.
uniprot
proteins
protein_family
DCC family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
1991322
uniprot
proteins
pubmed
20431009
uniprot
proteins
pubmed
21642953
uniprot
proteins
pubmed
2294591
uniprot
proteins
pubmed
28250454
uniprot
proteins
pubmed
28250456
uniprot
proteins
pubmed
38314870
uniprot
proteins
pubmed
7926722
uniprot
proteins
pubmed
8187090
uniprot
proteins
pubmed
8188295
uniprot
proteins
pubmed
8861902
uniprot
proteins
pubmed
9334332
uniprot
proteins
sequence_length
1447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 1098..1122; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins