MYO1G
entrez
64005
canonical
uniprot
B0I1T2
canonical
ensembl
ENSG00000136286
resolver
ensp
ENSP00000258787
resolver
genesymbol
MYO1G
resolver
genesymbol_syn
HA2
resolver
hgnc
HGNC:13880
resolver
uniprot
Q8TEI9
resolver
uniprot
Q8TES2
resolver
uniprot
Q96BE2
resolver
uniprot
Q96RI5
resolver
uniprot
Q96RI6
resolver
uniprot_entry
MYO1G_HUMAN
resolver
uniprot_sec
Q8TEI9
resolver
uniprot_sec
Q8TES2
resolver
uniprot_sec
Q96BE2
resolver
uniprot_sec
Q96RI5
resolver
uniprot_sec
Q96RI6
resolver
amino_acid_sequence
MEDEEGPEYGKPDFVLLDQVTMEDFMRNLQLRFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIARYQGRELYERPPHLYAVANAAYKAMKHRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKDVLLKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPIGGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRGSEDKQLHELHLERNPAVYNFTHQGAGLNMTVHSALDSDEQSHQAVTEAMRVIGFSPEEVESVHRILAAILHLGNIEFVETEEGGLQKEGLAVAEEALVDHVAELTATPRDLVLRSLLARTVASGGRELIEKGHTAAEASYARDACAKAVYQRLFEWVVNRINSVMEPRGRDPRRDGKDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGITWQSVEYFNNATIVDLVERPHRGILAVLDEACSSAGTITDRIFLQTLDMHHRHHLHYTSRQLCPTDKTMEFGRDFRIKHYAGDVTYSVEGFIDKNRDFLFQDFKRLLYNSTDPTLRAMWPDGQQDITEVTKRPLTAGTLFKNSMVALVENLASKEPFYVRCIKPNEDKVAGKLDENHCRHQVAYLGLLENVRVRRAGFASRQPYSRFLLRYKMTCEYTWPNHLLGSDKAAVSALLEQHGLQGDVAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQKAWRGTLARWRCRRLRAIYTIMRWFRRHKVRAHLAELQRRFQAARQPPLYGRDLVWPLPPAVLQPFQDTCHALFCRWRARQLVKNIPPSDMPQIKAKVAAMGALQGLRQDWGCRRAWARDYLSSATDNPTASSLFAQRLKTLQDKDGFGAVLFSSHVRKVNRFHKIRNRALLLTDQHLYKLDPDRQYRVMRAVPLEAVTGLSVTSGGDQLVVLHARGQDDLVVCLHRSRPPLDNRVGELVGVLAAHCQGEGRTLEVRVSDCIPLSHRGVRRLISVEPRPEQPEPDFRCARGSFTLLWPSR
uniprot
proteins
function
FUNCTION: Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.; FUNCTION: [Minor histocompatibility antigen HA-2]: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. {ECO:0000269|PubMed:11544309, ECO:0000305}.
uniprot
proteins
mass_dalton
116442
uniprot
proteins
mutagenesis
MUTAGEN 815; /note="K->A: Reduced membrane association."; /evidence="ECO:0000269|PubMed:20071333"; MUTAGEN 826; /note="R->A: Reduced membrane association."; /evidence="ECO:0000269|PubMed:20071333"; MUTAGEN 876; /note="R->A: No effect on membrane localization."; /evidence="ECO:0000269|PubMed:20071333"; MUTAGEN 880; /note="R->A: No effect on membrane localization."; /evidence="ECO:0000269|PubMed:20071333"; MUTAGEN 883; /note="K->A: No effect on membrane localization; when associated with R-885."; MUTAGEN 885; /note="R->A: No effect on membrane localization; when associated with K-883."; /evidence="ECO:0000269|PubMed:20071333"; MUTAGEN 898; /note="K->A: Reduced membrane association."; /evidence="ECO:0000269|PubMed:20071333"; MUTAGEN 903; /note="R->A: No effect on membrane localization; when associated with R-906."; /evidence="ECO:0000269|PubMed:20071333"; MUTAGEN 906; /note="R->A: No effect on membrane localization; when associated with R-903."; /evidence="ECO:0000269|PubMed:20071333"; MUTAGEN 909; /note="R->A: No effect on membrane localization."; /evidence="ECO:0000269|PubMed:20071333"; MUTAGEN 934; /note="R->A: No effect on membrane localization."; /evidence="ECO:0000269|PubMed:20071333"; MUTAGEN 945; /note="R->A: No effect on membrane localization."; /evidence="ECO:0000269|PubMed:20071333"; MUTAGEN 947; /note="R->A: No effect on membrane localization."; /evidence="ECO:0000269|PubMed:20071333"; MUTAGEN 953; /note="R->A: No effect on membrane localization."; /evidence="ECO:0000269|PubMed:20071333
uniprot
proteins
protein_family
Myosin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
11544309
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19968988
uniprot
proteins
pubmed
20071333
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7539551
uniprot
proteins
sequence_length
1018
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19968988, ECO:0000269|PubMed:20071333}; Peripheral membrane protein {ECO:0000269|PubMed:19968988, ECO:0000269|PubMed:20071333}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q5SUA5}. Note=Recruited to Fc-gamma receptor (Fc-gamma-R) phagocytic cup. In T-cells, transiently accumulates in discrete areas at the plasma membrane of migrating cells or when membranes are deformed (By similarity). Localization at the membrane is not highly dependent on phosphatidylinositol 4,5-bisphosphate levels. Released from the membrane in the presence of ATP. May be enriched in peripheral processes, such as microvilli or ruffles. {ECO:0000250|UniProtKB:Q5SUA5, ECO:0000269|PubMed:20071333}.
uniprot
proteins