Ptges
entrez
64292
canonical
uniprot
Q9JM51
canonical
ensembl
ENSMUSG00000050737
resolver
ensp
ENSMUSP00000099916
resolver
enst
ENSMUST00000102852
resolver
genesymbol
Ptges
resolver
genesymbol_syn
Pges
resolver
uniprot
Q3T9C5
resolver
uniprot
Q8BNP8
resolver
uniprot_entry
PTGES_MOUSE
resolver
uniprot_entry
Q8BNP8_MOUSE
resolver
uniprot_sec
Q3T9C5
resolver
activity_regulation
ACTIVITY REGULATION: Activity is increased markedly in macrophages and osteoblasts following pro-inflammatory stimuli. {ECO:0000269|PubMed:11795891}.
uniprot
proteins
amino_acid_sequence
MPSPGLVMESGQVLPAFLLCSTLLVIKMYAVAVITGQMRLRKKAFANPEDALKRGGLQYYRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPLIAWIHFLVVLTGRVVHTVAYLGKLNPRLRSGAYVLAQFSCFSMALQILWEVAHHL
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
ec_number
2.5.1.18
uniprot
proteins
ec_number
5.3.99.3
uniprot
proteins
function
FUNCTION: Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway (PubMed:10869354, PubMed:11795891). Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:10869354, PubMed:11795891). Similarly, catalyzes the conversion of PGH3 (derived from eicosapentaenoate (EPA, C20:5n-3)) to PGE3, though PGH2 remains the preferred substrate (By similarity). Plays a key role in inflammation response, fever and pain (PubMed:12835414, PubMed:14566340). Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity). {ECO:0000250|UniProtKB:O14684, ECO:0000269|PubMed:10869354, ECO:0000269|PubMed:11795891, ECO:0000269|PubMed:12835414, ECO:0000269|PubMed:14566340}.
uniprot
proteins
mass_dalton
17286
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; prostaglandin biosynthesis. {ECO:0000269|PubMed:10869354}.
uniprot
proteins
protein_family
MAPEG family
uniprot
proteins
pubmed
10869354
uniprot
proteins
pubmed
11795891
uniprot
proteins
pubmed
12835414
uniprot
proteins
pubmed
14566340
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11795891}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14684}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O14684}. Note=Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment. {ECO:0000250|UniProtKB:O14684}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..42; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O14684"; TRANSMEM 62..91; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O14684"; TRANSMEM 97..120; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O14684"; TRANSMEM 125..153; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O14684
uniprot
proteins