BMAL2
entrez
56938
canonical
uniprot
Q8WYA1
canonical
ensembl
ENSG00000029153
resolver
ensp
ENSP00000261178
resolver
ensp
ENSP00000266503
resolver
ensp
ENSP00000312247
resolver
ensp
ENSP00000379238
resolver
ensp
ENSP00000438545
resolver
ensp
ENSP00000442438
resolver
ensp
ENSP00000599574
resolver
ensp
ENSP00000599575
resolver
ensp
ENSP00000629909
resolver
ensp
ENSP00000629910
resolver
genesymbol
BMAL2
resolver
genesymbol_syn
ARNTL2
resolver
genesymbol_syn
BHLHE6
resolver
genesymbol_syn
CLIF
resolver
genesymbol_syn
MOP9
resolver
genesymbol_syn
PASD9
resolver
hgnc
HGNC:18984
resolver
uniprot
B7Z429
resolver
uniprot
F5H402
resolver
uniprot
Q8WYA2
resolver
uniprot
Q8WYA3
resolver
uniprot
Q8WYA4
resolver
uniprot
Q96J63
resolver
uniprot
Q9H2M4
resolver
uniprot
Q9NS70
resolver
uniprot
Q9NYQ4
resolver
uniprot
Q9NYQ5
resolver
uniprot_entry
BMAL2_HUMAN
resolver
uniprot_sec
B7Z429
resolver
uniprot_sec
F5H402
resolver
uniprot_sec
Q8WYA2
resolver
uniprot_sec
Q8WYA3
resolver
uniprot_sec
Q8WYA4
resolver
uniprot_sec
Q96J63
resolver
uniprot_sec
Q9H2M4
resolver
uniprot_sec
Q9NS70
resolver
uniprot_sec
Q9NYQ4
resolver
uniprot_sec
Q9NYQ5
resolver
amino_acid_sequence
MAAEEEAAAGGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQSGIMTEKVVEKLSQNPLTYLLSTRIEISASSGSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLMKDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL
uniprot
proteins
function
FUNCTION: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. {ECO:0000269|PubMed:11018023, ECO:0000269|PubMed:12738229, ECO:0000269|PubMed:14672706}.
uniprot
proteins
mass_dalton
70887
uniprot
proteins
pubmed
10864977
uniprot
proteins
pubmed
10964693
uniprot
proteins
pubmed
11018023
uniprot
proteins
pubmed
11554928
uniprot
proteins
pubmed
12738229
uniprot
proteins
pubmed
14672706
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
636
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:10964693}.
uniprot
proteins