GPAT3
entrez
84803
canonical
uniprot
Q53EU6
canonical
ensembl
ENSG00000138678
resolver
ensp
ENSP00000264409
resolver
ensp
ENSP00000378651
resolver
ensp
ENSP00000482571
resolver
ensp
ENSP00000530120
resolver
ensp
ENSP00000530121
resolver
enst
ENST00000264409
resolver
enst
ENST00000395226
resolver
enst
ENST00000611707
resolver
enst
ENST00000860061
resolver
enst
ENST00000860062
resolver
genesymbol
GPAT3
resolver
genesymbol
HMFN0839
resolver
genesymbol_syn
AGPAT9
resolver
genesymbol_syn
MAG1
resolver
hgnc
HGNC:28157
resolver
uniprot
A0A024RDG5
resolver
uniprot
A0A140VK86
resolver
uniprot
Q68CJ4
resolver
uniprot
Q6GPI6
resolver
uniprot
Q96NA3
resolver
uniprot_entry
A0A024RDG5_HUMAN
resolver
uniprot_entry
GPAT3_HUMAN
resolver
uniprot_sec
A0A140VK86
resolver
uniprot_sec
Q68CJ4
resolver
uniprot_sec
Q6GPI6
resolver
uniprot_sec
Q96NA3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethylmaleimide (NEM). {ECO:0000269|PubMed:17170135}.
uniprot
proteins
amino_acid_sequence
MEGAELAGKILSTWLTLVLGFILLPSVFGVSLGISEIYMKILVKTLEWATIRIEKGTPKESILKNSASVGIIQRDESPMEKGLSGLRGRDFELSDVFYFSKKGLEAIVEDEVTQRFSSEELVSWNLLTRTNVNFQYISLRLTMVWVLGVIVRYCVLLPLRVTLAFIGISLLVIGTTLVGQLPDSSLKNWLSELVHLTCCRICVRALSGTIHYHNKQYRPQKGGICVANHTSPIDVLILTTDGCYAMVGQVHGGLMGIIQRAMVKACPHVWFERSEMKDRHLVTKRLKEHIADKKKLPILIFPEGTCINNTSVMMFKKGSFEIGGTIHPVAIKYNPQFGDAFWNSSKYNMVSYLLRMMTSWAIVCDVWYMPPMTREEGEDAVQFANRVKSAIAIQGGLTELPWDGGLKRAKVKDIFKEEQQKNYSKMIVGNGSLS
uniprot
proteins
ec_number
2.3.1.15
uniprot
proteins
ec_number
2.3.1.51
uniprot
proteins
function
FUNCTION: Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:19318427). Protects cells against lipotoxicity (PubMed:30846318). {ECO:0000269|PubMed:17170135, ECO:0000269|PubMed:19318427, ECO:0000269|PubMed:30846318}.
uniprot
proteins
mass_dalton
48705
uniprot
proteins
pathway_participation
PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis.; PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.
uniprot
proteins
protein_family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15221005
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17002884
uniprot
proteins
pubmed
17170135
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19318427
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30846318
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17002884, ECO:0000269|PubMed:19318427}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..34; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 137..157; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins