Mief2
entrez
237781
canonical
uniprot
Q5NCS9
canonical
ensembl
ENSMUSG00000018599
resolver
ensp
ENSMUSP00000018743
resolver
enst
ENSMUST00000018743
resolver
genesymbol
Mief2
resolver
genesymbol_syn
Gm11
resolver
genesymbol_syn
Mid49
resolver
genesymbol_syn
Smcr7
resolver
uniprot_entry
MID49_MOUSE
resolver
amino_acid_sequence
MAEFSQKQRKQSGSEGLGSVVDFLLANARLVLGVGGAAVLGIATLAVKRLIDRATSPPDEDDTKGDSWKELSLLRATSPQKPQPPPAAFSQPLATGSPSPSVPVEPTPIHSPTTPKFSTIAPLCLTFQERLLAFERKHVITPEAHVTLAKQLAGDIALELQAYLRSKFPELPFGALVPGGPLYDGLQAGTAEHVRLLAPLELEPGLWSLVPGVDTVAREPRCWAVRRTQLEFHPRGCSPWDRFLVGGYLSSRVLLELLRKALSASVNWPAIGSLLGCLIWPDVASEELLLKVQHECLEFTLAVLMVVPGASTDDRLLLAWPLEGLASNLWLQDLYPVETARLRALDDQDAGTRRRLLLLLCGICRGHPALVRLGWSHLTQVVLHLGEEEVAWTEEALGERFLQALEFLVGSLEQASLPCHFNPSVNLLGNFREEEIDDIGYVLYSGLQVPESLF
uniprot
proteins
function
FUNCTION: Mitochondrial outer membrane protein which regulates mitochondrial organization. It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity. {ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:24508339}.
uniprot
proteins
mass_dalton
49624
uniprot
proteins
protein_family
MID49/MID51 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23283981
uniprot
proteins
pubmed
24508339
uniprot
proteins
sequence_length
454
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:24508339}; Single-pass membrane protein {ECO:0000269|PubMed:24508339}. Note=Colocalizes with DNM1L at mitochondrial membrane. Forms foci and rings around mitochondria.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins