Nkd2
entrez
72293
canonical
uniprot
Q8VE28
canonical
ensembl
ENSMUSG00000021567
resolver
ensp
ENSMUSP00000022051
resolver
ensp
ENSMUSP00000113794
resolver
genesymbol
Nkd2
resolver
uniprot
Q3TYU5
resolver
uniprot
Q3UM34
resolver
uniprot
Q8C4J8
resolver
uniprot
Q91Y45
resolver
uniprot
Q9D7U9
resolver
uniprot_entry
NKD2_MOUSE
resolver
uniprot_sec
Q3TYU5
resolver
uniprot_sec
Q3UM34
resolver
uniprot_sec
Q8C4J8
resolver
uniprot_sec
Q91Y45
resolver
uniprot_sec
Q9D7U9
resolver
amino_acid_sequence
MGKFQSKHAAAACKRRESPEGDSFVVPAYGSGRRGAEETDRRAGSGVEHRSRDKQELLNGDPKEGPFWDDKGSLEVVLPPEKSEGHEGQGQLFSTDDGEKAASREGPLRLSKKHLNIDALQCDVSVEEDNRQEWTFTLYDFDNSGKVTREDMSSLMHTIYEVVDASVNHSSGSSKTLRVKLTVSPEPSSKKECPLTGQDREPTRGRTEIELTDEPRVADRRLSAYSRKPNADPQPCSVRVPYCVDENTERRNHYLDLAGIENYTSKFGPGSPPEQARQEHHGRATHIPSRSRSQESDAHAIHHRRSQVLAEHVIPANEPATRALAAQPRIKGQEKQFLRSPKGPGKPLGTPGSGKPGKALSYCLQAVPLPQSAQDGHHLPQPPPQPPPQPYGHKRYRQKAREGHSPLKGHGQPTMVEHEVVRDLPPMLGPEGYVMPVVQRHEHHHHHEHHHHHHHHHFHPS
uniprot
proteins
function
FUNCTION: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
51501
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to rapid proteasomal degradation. Interaction with TGFA interferes with RNF25 binding and protects against ubiquitination mediated by RNF25 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
NKD family
uniprot
proteins
pubmed
11356022
uniprot
proteins
pubmed
15064403
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15511637
uniprot
proteins
pubmed
15546883
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17362910
uniprot
proteins
pubmed
17438140
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q969F2}. Cytoplasm {ECO:0000250|UniProtKB:Q969F2}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q969F2}.
uniprot
proteins