ABHD4
entrez
63874
canonical
uniprot
Q8TB40
canonical
ensembl
ENSG00000100439
resolver
ensp
ENSP00000414558
resolver
genesymbol
ABHD4
resolver
hgnc
HGNC:20154
resolver
uniprot
B4DDH7
resolver
uniprot
Q9H9E0
resolver
uniprot_entry
ABHD4_HUMAN
resolver
uniprot_sec
B4DDH7
resolver
uniprot_sec
Q9H9E0
resolver
amino_acid_sequence
MADDLEQQSQGWLSSWLPTWRPTSMSQLKNVEARILQCLQNKFLARYVSLPNQNKIWTVTVSPEQNDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPAFPRDPEGAEDEFVTSIETWRETMGIPSMILLGHSLGGFLATSYSIKYPDRVKHLILVDPWGFPLRPTNPSEIRAPPAWVKAVASVLGRSNPLAVLRVAGPWGPGLVQRFRPDFKRKFADFFEDDTISEYIYHCNAQNPSGETAFKAMMESFGWARRPMLERIHLIRKDVPITMIYGSDTWIDTSTGKKVKMQRPDSYVRDMEIKGASHHVYADQPHIFNAVVEEICDSVD
uniprot
proteins
ec_number
3.1.1.-
uniprot
proteins
function
FUNCTION: Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine. {ECO:0000250|UniProtKB:Q8VD66}.
uniprot
proteins
mass_dalton
38794
uniprot
proteins
protein_family
ABHD4/ABHD5 subfamily
uniprot
proteins
protein_family
Peptidase S33 family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
342
uniprot
proteins