TM6SF2
entrez
53345
canonical
uniprot
Q9BZW4
canonical
ensembl
ENSG00000213996
resolver
ensp
ENSP00000374014
resolver
genesymbol
TM6SF2
resolver
hgnc
HGNC:11861
resolver
uniprot
Q0IJ64
resolver
uniprot_entry
TM6S2_HUMAN
resolver
uniprot_sec
Q0IJ64
resolver
amino_acid_sequence
MDIPPLAGKIAALSLSALPVSYALNHVSALSHPLWVALMSALILGLLFVAVYSLSHGEVSYDPLYAVFAVFAFTSVVDLIIALQEDSYVVGFMEFYTKEGEPYLRTAHGVFICYWDGTVHYLLYLAMAGAICRRKRYRNFGLYWLGSFAMSILVFLTGNILGKYSSEIRPAFFLTIPYLLVPCWAGMKVFSQPRALTRCTANMVQEEQRKGLLQRPADLALVIYLILAGFFTLFRGLVVLDCPTDACFVYIYQYEPYLRDPVAYPKVQMLMYMFYVLPFCGLAAYALTFPGCSWLPDWALVFAGGIGQAQFSHMGASMHLRTPFTYRVPEDTWGCFFVCNLLYALGPHLLAYRCLQWPAFFHQPPPSDPLALHKKQH
uniprot
proteins
function
FUNCTION: Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content (PubMed:24531328, PubMed:24927523). May function as sterol isomerase (PubMed:25566323). {ECO:0000269|PubMed:24531328, ECO:0000269|PubMed:24927523, ECO:0000303|PubMed:25566323}.
uniprot
proteins
mass_dalton
42554
uniprot
proteins
protein_family
TM6SF family
uniprot
proteins
pubmed
11124529
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24531328
uniprot
proteins
pubmed
24633158
uniprot
proteins
pubmed
24927523
uniprot
proteins
pubmed
24978903
uniprot
proteins
pubmed
25566323
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25566323}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:25566323}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 34..54; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 63..83; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 111..131; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 332..352; /note="Helical; Name=9"; /evidence="ECO:0000255
uniprot
proteins