Slc22a3
entrez
20519
canonical
uniprot
Q9WTW5
canonical
ensembl
ENSMUSG00000023828
resolver
ensp
ENSMUSP00000024595
resolver
enst
ENSMUST00000024595
resolver
genesymbol
Slc22a3
resolver
genesymbol_syn
Oct3
resolver
uniprot
Q547K2
resolver
uniprot
Q9R209
resolver
uniprot_entry
Q547K2_MOUSE
resolver
uniprot_entry
S22A3_MOUSE
resolver
uniprot_sec
Q9R209
resolver
amino_acid_sequence
MPTFDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPEEEWNLTTPELHVPAERRGQGHCHRYLLEATNTSSELSCDPLTAFPNRSAPLVSCSGDWRYVETHSTIVSQFDLVCSNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIIYLISCFGVGITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLSSNYSEITVTDEEVSNPSCLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGLIGGNLYIDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLPEGIPWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLGSSQLHQCGRKKKTQVSTSDV
uniprot
proteins
function
FUNCTION: Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10966924, PubMed:18513366). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:10966924). Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter (By similarity). Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, homovanillic acid, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain (PubMed:18513366, PubMed:19416912). Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency (By similarity). May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow (PubMed:10966924). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (By similarity). Mediates the transport of polyamine spermidine and putrescine (By similarity). Mediates the bidirectional transport of polyamine agmatine (By similarity). Also transports guanidine (PubMed:10966924). Mediates the transport of choline (By similarity). May mediate intracellular transport of organic cations due to its localization on endomembranes, thereby contributing to amine metabolism and intracellular signaling (PubMed:27659446). {ECO:0000250|UniProtKB:O75751, ECO:0000250|UniProtKB:O88446, ECO:0000269|PubMed:10966924, ECO:0000269|PubMed:18513366, ECO:0000269|PubMed:19416912, ECO:0000269|PubMed:27659446}.
uniprot
proteins
mass_dalton
61053
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
10966924
uniprot
proteins
pubmed
18513366
uniprot
proteins
pubmed
19416912
uniprot
proteins
pubmed
27659446
uniprot
proteins
pubmed
9933568
uniprot
proteins
sequence_length
551
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27659446}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:O75751}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000250|UniProtKB:O75751}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000269|PubMed:27659446}. Endomembrane system {ECO:0000269|PubMed:27659446}. Nucleus membrane {ECO:0000305|PubMed:27659446}. Nucleus outer membrane {ECO:0000250|UniProtKB:O88446}. Note=Located to neuronal and glial endomembranes, including mitochondrial and nuclear membranes. {ECO:0000269|PubMed:27659446}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 264..284; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 376..396; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 464..484; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 493..513; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins