Syt1
entrez
20979
canonical
uniprot
P46096
canonical
ensembl
ENSMUSG00000035864
resolver
ensp
ENSMUSP00000063293
resolver
ensp
ENSMUSP00000100912
resolver
ensp
ENSMUSP00000290520
resolver
ensp
ENSMUSP00000290521
resolver
ensp
ENSMUSP00000290525
resolver
ensp
ENSMUSP00000290535
resolver
ensp
ENSMUSP00000290537
resolver
ensp
ENSMUSP00000290538
resolver
ensp
ENSMUSP00000290539
resolver
ensp
ENSMUSP00000290547
resolver
enst
ENSMUST00000064054
resolver
enst
ENSMUST00000105276
resolver
genesymbol
Syt1
resolver
genesymbol_syn
SytI
resolver
uniprot
H6RXZ1
resolver
uniprot_entry
H6RXZ1_MOUSE
resolver
uniprot_entry
SYT1_MOUSE
resolver
amino_acid_sequence
MVSASRPEALAAPVTTVATLVPHNATEPASPGEGKEDAFSKLKQKFMNELHKIPLPPWALIAIAIVAVLLVVTCCFCVCKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKDQALKDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAMLAVKK
uniprot
proteins
function
FUNCTION: Calcium sensor that participates in triggering neurotransmitter release at the synapse (PubMed:11242035). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (PubMed:7961887). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (By similarity). {ECO:0000250|UniProtKB:P21579, ECO:0000269|PubMed:11242035, ECO:0000269|PubMed:7961887}.
uniprot
proteins
mass_dalton
47418
uniprot
proteins
mutagenesis
MUTAGEN 233; /note="R->Q: Reduces affinity for calcium and results in decreased calcium-dependent neurotransmitter release."; /evidence="ECO:0000269|PubMed:11242035"; MUTAGEN 236; /note="K->Q: No effect on calcium-dependent neurotransmitter release."; /evidence="ECO:0000269|PubMed:11242035
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:P21707}.
uniprot
proteins
protein_family
Synaptotagmin family
uniprot
proteins
pubmed
11242035
uniprot
proteins
pubmed
15466855
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17190793
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21496647
uniprot
proteins
pubmed
23345244
uniprot
proteins
pubmed
27052163
uniprot
proteins
pubmed
7961887
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:23345244}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasm {ECO:0000250|UniProtKB:P21707}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..79; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins