PRG2
entrez
5553
canonical
uniprot
P13727
canonical
ensembl
ENSG00000186652
resolver
ensp
ENSP00000312134
resolver
ensp
ENSP00000433016
resolver
ensp
ENSP00000433231
resolver
ensp
ENSP00000556084
resolver
genesymbol
PRG2
resolver
genesymbol_syn
MBP
resolver
hgnc
HGNC:9362
resolver
uniprot
A6XMW0
resolver
uniprot
B2R5I1
resolver
uniprot
P81448
resolver
uniprot
Q14227
resolver
uniprot
Q6ICT2
resolver
uniprot_entry
PRG2_HUMAN
resolver
uniprot_sec
A6XMW0
resolver
uniprot_sec
B2R5I1
resolver
uniprot_sec
P81448
resolver
uniprot_sec
Q14227
resolver
uniprot_sec
Q6ICT2
resolver
amino_acid_sequence
MKLPLLLALLFGAVSALHLRSETSTFETPLGAKTLPEDEETPEQEMEETPCRELEEEEEWGSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQAWFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRWNFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY
uniprot
proteins
function
FUNCTION: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. {ECO:0000269|PubMed:10913121}.
uniprot
proteins
mass_dalton
25206
uniprot
proteins
post_translational_modification
PTM: Nitrated. {ECO:0000269|PubMed:18694936}.
uniprot
proteins
pubmed
10491647
uniprot
proteins
pubmed
10913121
uniprot
proteins
pubmed
11319227
uniprot
proteins
pubmed
12421832
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1565101
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18694936
uniprot
proteins
pubmed
2323577
uniprot
proteins
pubmed
2501794
uniprot
proteins
pubmed
25326458
uniprot
proteins
pubmed
2584934
uniprot
proteins
pubmed
3171483
uniprot
proteins
pubmed
3199069
uniprot
proteins
pubmed
32337544
uniprot
proteins
pubmed
3410852
uniprot
proteins
pubmed
3422083
uniprot
proteins
pubmed
36213313
uniprot
proteins
pubmed
37453717
uniprot
proteins
pubmed
7508748
uniprot
proteins
pubmed
7524900
uniprot
proteins
pubmed
7526035
uniprot
proteins
pubmed
7531438
uniprot
proteins
pubmed
7539791
uniprot
proteins
pubmed
7685339
uniprot
proteins
pubmed
8137941
uniprot
proteins
pubmed
8507662
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Bone marrow proteoglycan]: Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:37453717}. Note=The proform is secreted.; SUBCELLULAR LOCATION: [Eosinophil granule major basic protein]: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).
uniprot
proteins