Calm2
entrez
50663
canonical
uniprot
P0DP30
canonical
ensembl
ENSRNOG00000016770
resolver
ensembl
ENSRNOG00000067086
resolver
ensembl
ENSRNOG00000072513
resolver
ensembl
ENSRNOG00055015152
resolver
ensembl
ENSRNOG00055031474
resolver
ensembl
ENSRNOG00060022413
resolver
ensembl
ENSRNOG00065014668
resolver
ensembl
ENSRNOG00065032582
resolver
ensp
ENSRNOP00000076629
resolver
ensp
ENSRNOP00000103420
resolver
ensp
ENSRNOP00000105419
resolver
ensp
ENSRNOP00055021172
resolver
ensp
ENSRNOP00055045085
resolver
ensp
ENSRNOP00060032095
resolver
ensp
ENSRNOP00065018950
resolver
ensp
ENSRNOP00065046171
resolver
enst
ENSRNOT00000118114
resolver
enst
ENSRNOT00000124429
resolver
enst
ENSRNOT00000132627
resolver
enst
ENSRNOT00055025979
resolver
enst
ENSRNOT00055054523
resolver
enst
ENSRNOT00060038843
resolver
enst
ENSRNOT00065024262
resolver
enst
ENSRNOT00065056044
resolver
genesymbol
Calm2
resolver
genesymbol_syn
CaMII
resolver
genesymbol_syn
Cam2
resolver
genesymbol_syn
Camb
resolver
uniprot
P02593
resolver
uniprot
P62161
resolver
uniprot
P70667
resolver
uniprot
P99014
resolver
uniprot
Q61379
resolver
uniprot
Q61380
resolver
uniprot_entry
CALM2_RAT
resolver
uniprot_sec
P02593
resolver
uniprot_sec
P62161
resolver
uniprot_sec
P70667
resolver
uniprot_sec
P99014
resolver
uniprot_sec
Q61379
resolver
uniprot_sec
Q61380
resolver
amino_acid_sequence
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
uniprot
proteins
function
FUNCTION: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. {ECO:0000250|UniProtKB:P0DP24}.
uniprot
proteins
mass_dalton
16838
uniprot
proteins
post_translational_modification
PTM: Ubiquitination results in a strongly decreased activity. {ECO:0000250}.; PTM: Phosphorylation results in a decreased activity. {ECO:0000269|PubMed:12392717}.
uniprot
proteins
protein_family
Calmodulin family
uniprot
proteins
pubmed
12392717
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18056528
uniprot
proteins
pubmed
201628
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2445749
uniprot
proteins
pubmed
2527998
uniprot
proteins
pubmed
3037336
uniprot
proteins
pubmed
8576129
uniprot
proteins
sequence_length
149
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. {ECO:0000250}.
uniprot
proteins