NCOA1
entrez
8648
canonical
uniprot
Q15788
canonical
ensembl
ENSG00000084676
resolver
ensp
ENSP00000320940
resolver
ensp
ENSP00000379197
resolver
ensp
ENSP00000385097
resolver
ensp
ENSP00000588399
resolver
ensp
ENSP00000588402
resolver
ensp
ENSP00000588404
resolver
ensp
ENSP00000620213
resolver
ensp
ENSP00000693789
resolver
ensp
ENSP00000693790
resolver
ensp
ENSP00000693797
resolver
genesymbol
NCOA1
resolver
genesymbol_syn
BHLHE74
resolver
genesymbol_syn
SRC1
resolver
hgnc
HGNC:7668
resolver
uniprot
O00150
resolver
uniprot
O43792
resolver
uniprot
O43793
resolver
uniprot
Q13071
resolver
uniprot
Q13420
resolver
uniprot
Q2T9G5
resolver
uniprot
Q53SX3
resolver
uniprot
Q6GVI5
resolver
uniprot
Q7KYV3
resolver
uniprot_entry
NCOA1_HUMAN
resolver
uniprot_sec
O00150
resolver
uniprot_sec
O43792
resolver
uniprot_sec
O43793
resolver
uniprot_sec
Q13071
resolver
uniprot_sec
Q13420
resolver
uniprot_sec
Q2T9G5
resolver
uniprot_sec
Q53SX3
resolver
uniprot_sec
Q6GVI5
resolver
uniprot_sec
Q7KYV3
resolver
amino_acid_sequence
MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAVTSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAINQSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGTMPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSFGNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTEADGTQQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLTE
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children. {ECO:0000269|PubMed:15313887}.
uniprot
proteins
ec_number
2.3.1.48
uniprot
proteins
function
FUNCTION: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}.
uniprot
proteins
mass_dalton
156757
uniprot
proteins
mutagenesis
MUTAGEN 636..637; /note="LL->AA: Slightly affects interactions with steroid receptors. Abolishes interactions with steroid receptors; when associated with A-693; A-694; A-752 and A-753."; /evidence="ECO:0000269|PubMed:9427757"; MUTAGEN 693..694; /note="LL->AA: Slightly affects interactions with steroid receptors. Abolishes interactions with steroid receptors; when associated with A-636; A-637; A-752 and A-753."; /evidence="ECO:0000269|PubMed:9427757"; MUTAGEN 732; /note="K->R: Abolishes sumoylation; when associated with R-774."; /evidence="ECO:0000269|PubMed:12529333"; MUTAGEN 752..753; /note="LL->AA: Slightly affects interactions with steroid receptors. Abolishes interactions with steroid receptors; when associated with A-636; A-637; A-693 and A-694."; /evidence="ECO:0000269|PubMed:9427757"; MUTAGEN 774; /note="K->R: Abolishes sumoylation; when associated with R-732."; /evidence="ECO:0000269|PubMed:12529333"; MUTAGEN 800; /note="K->R: Does not affect sumoylation of the protein."; /evidence="ECO:0000269|PubMed:12529333"; MUTAGEN 846; /note="K->R: Does not affect sumoylation of the protein."; /evidence="ECO:0000269|PubMed:12529333"; MUTAGEN 1378; /note="K->R: Does not affect sumoylation of the protein."; /evidence="ECO:0000269|PubMed:12529333
uniprot
proteins
post_translational_modification
PTM: Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein. {ECO:0000269|PubMed:12529333}.; PTM: Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites. {ECO:0000269|PubMed:12529333}.
uniprot
proteins
protein_family
SRC/p160 nuclear receptor coactivator family
uniprot
proteins
pubmed
10449719
uniprot
proteins
pubmed
10508479
uniprot
proteins
pubmed
10567404
uniprot
proteins
pubmed
10594042
uniprot
proteins
pubmed
10660621
uniprot
proteins
pubmed
10722692
uniprot
proteins
pubmed
11250900
uniprot
proteins
pubmed
11698662
uniprot
proteins
pubmed
11773079
uniprot
proteins
pubmed
11831720
uniprot
proteins
pubmed
11864604
uniprot
proteins
pubmed
12039952
uniprot
proteins
pubmed
12138096
uniprot
proteins
pubmed
12529333
uniprot
proteins
pubmed
12917342
uniprot
proteins
pubmed
12954634
uniprot
proteins
pubmed
15313887
uniprot
proteins
pubmed
15367689
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16606617
uniprot
proteins
pubmed
16957778
uniprot
proteins
pubmed
17116691
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18690216
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19786558
uniprot
proteins
pubmed
20047962
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25219498
uniprot
proteins
pubmed
25452582
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28698609
uniprot
proteins
pubmed
7481822
uniprot
proteins
pubmed
8754792
uniprot
proteins
pubmed
9223281
uniprot
proteins
pubmed
9223431
uniprot
proteins
pubmed
9296499
uniprot
proteins
pubmed
9427757
uniprot
proteins
pubmed
9575154
uniprot
proteins
pubmed
9744270
uniprot
proteins
sequence_length
1441
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
uniprot
proteins