Kcnab2
entrez
29738
canonical
uniprot
P62483
canonical
ensembl
ENSRNOG00000011550
resolver
ensp
ENSRNOP00000015840
resolver
ensp
ENSRNOP00000081886
resolver
ensp
ENSRNOP00000085478
resolver
enst
ENSRNOT00000015840
resolver
enst
ENSRNOT00000101700
resolver
genesymbol
Kcnab2
resolver
genesymbol_syn
Ckbeta2
resolver
genesymbol_syn
Kcnb3
resolver
uniprot
A0A8I6GCY0
resolver
uniprot
A0A8L2Q7L3
resolver
uniprot
P97381
resolver
uniprot
Q60942
resolver
uniprot
Q64284
resolver
uniprot_entry
A0A8I6GCY0_RAT
resolver
uniprot_entry
A0A8L2Q7L3_RAT
resolver
uniprot_entry
KCAB2_RAT
resolver
uniprot_sec
P97381
resolver
uniprot_sec
Q60942
resolver
uniprot_sec
Q64284
resolver
amino_acid_sequence
MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEIDSILGNKPYSKKDYRS
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
function
FUNCTION: Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:10896669, PubMed:18003609, PubMed:21357749, PubMed:9763623). The beta-2/KCNAB2 subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:21357749). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:9763623). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates (PubMed:18672894, PubMed:21209188). Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet) (PubMed:18672894). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability (PubMed:18672894). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). {ECO:0000250|UniProtKB:P62482, ECO:0000269|PubMed:10896669, ECO:0000269|PubMed:18003609, ECO:0000269|PubMed:18672894, ECO:0000269|PubMed:21209188, ECO:0000269|PubMed:21357749, ECO:0000269|PubMed:9763623}.
uniprot
proteins
mass_dalton
41021
uniprot
proteins
mutagenesis
MUTAGEN 9; /note="S->A: Impairs interaction with MAPRE1 and association with microtubules."; /evidence="ECO:0000269|PubMed:21357749"; MUTAGEN 20; /note="S->A: No effect on interaction with MAPRE1 and association with microtubules."; /evidence="ECO:0000269|PubMed:21357749"; MUTAGEN 31; /note="S->A: Impairs interaction with MAPRE1 and association with microtubules."; /evidence="ECO:0000269|PubMed:21357749"; MUTAGEN 90; /note="Y->F: Abolishes enzyme activity, but has no effect on NADPH binding."; /evidence="ECO:0000269|PubMed:18672894, ECO:0000269|PubMed:21209188
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1. {ECO:0000269|PubMed:10477520}.
uniprot
proteins
protein_family
Shaker potassium channel beta subunit family
uniprot
proteins
pubmed
10399921
uniprot
proteins
pubmed
10477520
uniprot
proteins
pubmed
10884227
uniprot
proteins
pubmed
10896669
uniprot
proteins
pubmed
11086297
uniprot
proteins
pubmed
12860406
uniprot
proteins
pubmed
15618540
uniprot
proteins
pubmed
16002581
uniprot
proteins
pubmed
16079148
uniprot
proteins
pubmed
16770729
uniprot
proteins
pubmed
18003609
uniprot
proteins
pubmed
18004376
uniprot
proteins
pubmed
18672894
uniprot
proteins
pubmed
18806782
uniprot
proteins
pubmed
20360102
uniprot
proteins
pubmed
20534430
uniprot
proteins
pubmed
21209188
uniprot
proteins
pubmed
21357749
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23318870
uniprot
proteins
pubmed
23705070
uniprot
proteins
pubmed
8183366
uniprot
proteins
pubmed
9334400
uniprot
proteins
pubmed
9763623
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21357749}. Membrane {ECO:0000269|PubMed:21357749, ECO:0000269|PubMed:9334400}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:23318870}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:21357749, ECO:0000269|PubMed:9334400}. Synapse, synaptosome {ECO:0000269|PubMed:21357749}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21357749}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated (PubMed:21357749). {ECO:0000269|PubMed:21357749, ECO:0000305}.
uniprot
proteins