Aldh1a2
entrez
116676
canonical
uniprot
Q63639
canonical
ensembl
ENSRNOG00000055049
resolver
ensembl
ENSRNOG00055006737
resolver
ensembl
ENSRNOG00060020928
resolver
ensembl
ENSRNOG00065017563
resolver
ensp
ENSRNOP00000073203
resolver
ensp
ENSRNOP00055008603
resolver
ensp
ENSRNOP00060029828
resolver
ensp
ENSRNOP00065023323
resolver
enst
ENSRNOT00000079115
resolver
enst
ENSRNOT00055011019
resolver
enst
ENSRNOT00060036263
resolver
enst
ENSRNOT00065029377
resolver
genesymbol
Aldh1a2
resolver
genesymbol_syn
Raldh2
resolver
uniprot
Q4FZY8
resolver
uniprot_entry
AL1A2_RAT
resolver
uniprot_sec
Q4FZY8
resolver
amino_acid_sequence
MTSSEIAMPGEVKADPAALMASLQLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVCNPATGEQVCEVQEADKVDIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRATLATMESLNGGKPFLQAFYIDLQGVIKTLRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFTWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVVNILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVKRSVERAKRRIVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALMVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
uniprot
proteins
ec_number
1.2.1.36
uniprot
proteins
function
FUNCTION: Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (By similarity) (PubMed:8663198). Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (By similarity). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (PubMed:8663198). Lacks activity with benzaldehyde, acetaldehyde and octanal (PubMed:8663198). Displays complete lack of activity with citral (PubMed:8663198). {ECO:0000250|UniProtKB:Q62148, ECO:0000269|PubMed:8663198}.
uniprot
proteins
mass_dalton
56640
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000269|PubMed:8663198}.
uniprot
proteins
protein_family
Aldehyde dehydrogenase family
uniprot
proteins
pubmed
10320326
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8663198
uniprot
proteins
sequence_length
518
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins