Agpat3
entrez
28169
canonical
uniprot
Q9D517
canonical
ensembl
ENSMUSG00000001211
resolver
ensp
ENSMUSP00000001240
resolver
ensp
ENSMUSP00000101026
resolver
ensp
ENSMUSP00000101027
resolver
ensp
ENSMUSP00000101028
resolver
ensp
ENSMUSP00000101029
resolver
ensp
ENSMUSP00000132954
resolver
ensp
ENSMUSP00000311125
resolver
ensp
ENSMUSP00000311139
resolver
ensp
ENSMUSP00000311145
resolver
ensp
ENSMUSP00000311147
resolver
ensp
ENSMUSP00000311156
resolver
ensp
ENSMUSP00000356504
resolver
enst
ENSMUST00000001240
resolver
enst
ENSMUST00000105387
resolver
enst
ENSMUST00000105388
resolver
enst
ENSMUST00000105389
resolver
enst
ENSMUST00000105390
resolver
enst
ENSMUST00000166360
resolver
genesymbol
Agpat3
resolver
genesymbol_syn
Lpaat3
resolver
uniprot
C4B4E7
resolver
uniprot
Q7TT39
resolver
uniprot
Q8BST2
resolver
uniprot_entry
PLCC_MOUSE
resolver
uniprot_sec
C4B4E7
resolver
uniprot_sec
Q7TT39
resolver
uniprot_sec
Q8BST2
resolver
activity_regulation
ACTIVITY REGULATION: In males, activity increases in an age-dependent fashion, maybe derived from the induction by sex-hormones. {ECO:0000269|PubMed:19114731}.
uniprot
proteins
amino_acid_sequence
MGLLAYLKTQFVVHLLIGFVFVVSGLIINFTQLCTLALWPISKHLYRRINCRLAYSLWSQLVMLLEWWSCTECTLFTDQATVDHFGKEHVVVILNHNFEIDFLCGWTMCERFGVLGSSKVLAKRELLCVPLIGWTWYFLEIVFCKRKWEEDRDTVIEGLRRLADYPEYMWFLLYCEGTRFTETKHRISMEVAASKGLPPLKYHLLPRTKGFTTAVQCLRGTVAAIYDVTLNFRGNKNPSLLGILYGKKYEADMCVRRFPLEDIPADETSAAQWLHKLYQEKDALQEMYKQKGVFPGEQFKPARRPWTLLNFLCWATILLSPLFSFVLGVFASGSPLLILTFLGFVGAASFGVRRLIGVTEIEKGSSYGNQELKKKE
uniprot
proteins
ec_number
2.3.1.51
uniprot
proteins
function
FUNCTION: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:15367102). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (By similarity). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (By similarity). Has a preference for arachidonoyl-CoA as a donor (PubMed:19114731). Also has a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (PubMed:19114731). {ECO:0000250|UniProtKB:Q9NRZ7, ECO:0000269|PubMed:15367102, ECO:0000269|PubMed:19114731}.
uniprot
proteins
mass_dalton
43296
uniprot
proteins
mutagenesis
MUTAGEN 96; /note="H->A: Loss of LPA acyltransferase and LPI acyltransferase activities."; /evidence="ECO:0000269|PubMed:19114731"; MUTAGEN 101; /note="D->A: Loss of LPA acyltransferase and LPI acyltransferase activities."; /evidence="ECO:0000269|PubMed:19114731"; MUTAGEN 176; /note="E->A: Loss of LPA acyltransferase and LPI acyltransferase activities."; /evidence="ECO:0000269|PubMed:19114731
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
uniprot
proteins
protein_family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
uniprot
proteins
pubmed
15367102
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19114731
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19114731}; Multi-pass membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000250|UniProtKB:Q9NRZ7}.
uniprot
proteins
transmembrane_region
TRANSMEM 125..145; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 317..339; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins