RHBG
entrez
57127
canonical
uniprot
Q9H310
canonical
ensembl
ENSG00000132677
resolver
ensp
ENSP00000441197
resolver
genesymbol
RHBG
resolver
hgnc
HGNC:14572
resolver
uniprot
A8K475
resolver
uniprot
Q5SZW4
resolver
uniprot
Q5SZW6
resolver
uniprot
Q5SZW7
resolver
uniprot
Q6P193
resolver
uniprot
Q6YJI2
resolver
uniprot
Q6YJI3
resolver
uniprot_entry
RHBG_HUMAN
resolver
uniprot_sec
A8K475
resolver
uniprot_sec
Q5SZW4
resolver
uniprot_sec
Q5SZW6
resolver
uniprot_sec
Q5SZW7
resolver
uniprot_sec
Q6P193
resolver
uniprot_sec
Q6YJI2
resolver
uniprot_sec
Q6YJI3
resolver
amino_acid_sequence
MAGSPSRAAGRRLQLPLLCLFLQGATAVLFAVFVRYNHKTDAALWHRSNHSNADNEFYFRYPSFQDVHAMVFVGFGFLMVFLQRYGFSSVGFTFLLAAFALQWSTLVQGFLHSFHGGHIHVGVESMINADFCAGAVLISFGAVLGKTGPTQLLLMALLEVVLFGINEFVLLHLLGVRDAGGSMTIHTFGAYFGLVLSRVLYRPQLEKSKHRQGSVYHSDLFAMIGTIFLWIFWPSFNAALTALGAGQHRTALNTYYSLAASTLGTFALSALVGEDGRLDMVHIQNAALAGGVVVGTSSEMMLTPFGALAAGFLAGTVSTLGYKFFTPILESKFKVQDTCGVHNLHGMPGVLGALLGVLVAGLATHEAYGDGLESVFPLIAEGQRSATSQAMHQLFGLFVTLMFASVGGGLGGLLLKLPFLDSPPDSQHYEDQVHWQVPGEHEDKAQRPLRVEEADTQA
uniprot
proteins
function
FUNCTION: Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the basolateral plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. May transport either NH4(+) or NH3 ammonia species predominantly mediating an electrogenic NH4(+) transport (PubMed:15284342, PubMed:15929723, PubMed:24077989). May act as a CO2 channel providing for renal acid secretion (PubMed:24077989). {ECO:0000269|PubMed:15284342, ECO:0000269|PubMed:15929723, ECO:0000269|PubMed:24077989}.
uniprot
proteins
mass_dalton
49481
uniprot
proteins
mutagenesis
MUTAGEN 178; /note="D->N: Impairs protein stability resulting in loss of transporter activity."; /evidence="ECO:0000269|PubMed:24077989"; MUTAGEN 419; /note="F->A: Loss of interaction with ANK3. Intracellular retention; when associated with A-420 and A-421."; /evidence="ECO:0000269|PubMed:15611082"; MUTAGEN 420; /note="L->A: Partial loss of interaction with ANK3. Intracellular retention; when associated with A-419 and A-421."; /evidence="ECO:0000269|PubMed:15611082"; MUTAGEN 421; /note="D->A: Partial loss of interaction with ANK3. Intracellular retention; when associated with A-419 and A-420."; /evidence="ECO:0000269|PubMed:15611082
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
Ammonium transporter (TC 2.A.49) family
uniprot
proteins
protein_family
Rh subfamily
uniprot
proteins
pubmed
11024028
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15284342
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15611082
uniprot
proteins
pubmed
15929723
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
24077989
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11024028, ECO:0000269|PubMed:15929723}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:15611082}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..34; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 125..145; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 179..201; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 220..240; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 252..272; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 283..303; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 347..367; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 394..414; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins