Nr5a1
entrez
26423
canonical
uniprot
P33242
canonical
ensembl
ENSMUSG00000026751
resolver
ensp
ENSMUSP00000028084
resolver
ensp
ENSMUSP00000108504
resolver
genesymbol
Nr5a1
resolver
genesymbol_syn
Ftzf1
resolver
uniprot
Q812G5
resolver
uniprot_entry
STF1_MOUSE
resolver
uniprot_sec
Q812G5
resolver
amino_acid_sequence
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPPPDYMLPPSLHAPEPKALVSGPPSGPLGDFGAPSLPMAVPGPHGPLAGYLYPAFSNRTIKSEYPEPYASPPQQPGPPYSYPEPFSGGPNVPELILQLLQLEPEEDQVRARIVGCLQEPAKSRSDQPAPFSLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVLDHIYRQVQYGKEDSILLVTGQEVELSTVAVQAGSLLHSLVLRAQELVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSLVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
uniprot
proteins
function
FUNCTION: Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity). Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. {ECO:0000250, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:18988706}.
uniprot
proteins
mass_dalton
52077
uniprot
proteins
mutagenesis
MUTAGEN 270; /note="A->W: Reduced lipid binding and transactivation. Abolishes ligand binding and reduces transactivation; when associated with F-345."; /evidence="ECO:0000269|PubMed:15707893, ECO:0000269|PubMed:18988706"; MUTAGEN 314; /note="R->M: Strongly reduced transactivation."; /evidence="ECO:0000269|PubMed:15707893"; MUTAGEN 345; /note="L->F: Abolishes ligand binding and reduces transactivation; when associated with W-270."; /evidence="ECO:0000269|PubMed:15721253, ECO:0000269|PubMed:18988706"; MUTAGEN 345; /note="L->W: Strongly reduced transactivation."; /evidence="ECO:0000269|PubMed:15721253, ECO:0000269|PubMed:18988706"; MUTAGEN 348; /note="L->W: Strongly reduced transactivation."; /evidence="ECO:0000269|PubMed:15721253"; MUTAGEN 349; /note="V->W: Strongly reduced transactivation."; /evidence="ECO:0000269|PubMed:15721253"; MUTAGEN 352; /note="A->W: Strongly reduced transactivation."; /evidence="ECO:0000269|PubMed:15721253"; MUTAGEN 434; /note="A->W: Strongly reduced transactivation."; /evidence="ECO:0000269|PubMed:15721253"; MUTAGEN 440; /note="H->D: Strongly reduced transactivation; when associated with D-442."; MUTAGEN 441; /note="K->E: Strongly reduced transactivation."; /evidence="ECO:0000269|PubMed:15721253"; MUTAGEN 442; /note="H->D: Strongly reduced transactivation; when associated with D-440.
uniprot
proteins
post_translational_modification
PTM: Acetylation stimulates the transcriptional activity. {ECO:0000250}.; PTM: Sumoylation reduces CDK7-mediated phosphorylation on Ser-203. {ECO:0000250}.; PTM: Phosphorylated on Ser-203 by CDK7. This phosphorylation promotes transcriptional activity (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
NR5 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
12239114
uniprot
proteins
pubmed
1545809
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15707893
uniprot
proteins
pubmed
15721253
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17210646
uniprot
proteins
pubmed
18988706
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8395013
uniprot
proteins
pubmed
8413309
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins