Anks6
entrez
362515
canonical
uniprot
P0C0T2
canonical
ensembl
ENSRNOG00000023309
resolver
ensp
ENSRNOP00000056754
resolver
ensp
ENSRNOP00000110315
resolver
enst
ENSRNOT00000060005
resolver
enst
ENSRNOT00000146576
resolver
genesymbol
Anks6
resolver
genesymbol_syn
Pkdr1
resolver
genesymbol_syn
Samd6
resolver
uniprot
A0A0G2JSX8
resolver
uniprot
A0ABK0LVC9
resolver
uniprot
Q2VWC0
resolver
uniprot
Q5BJL2
resolver
uniprot_entry
A0A0G2JSX8_RAT
resolver
uniprot_entry
A0ABK0LVC9_RAT
resolver
uniprot_entry
ANKS6_RAT
resolver
uniprot_sec
Q2VWC0
resolver
uniprot_sec
Q5BJL2
resolver
amino_acid_sequence
MGEGALAPGLQLLLRACEQGDTDTARRLLEPGGEPVAGSEAGAEPAGPEAARAVEAGTPVPVDCSDEAGNSALQLAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARCGHASVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGATVDHRNPSGESTASGGSRDELLGITALMAAVQHGHEAVVRLLMEWGADPNHTARTVGWSPLMLAALLGKLSVVQQLVEKGANPDHLGVLEKTAFEVALDRKHRDLADYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPNHVNLVNGDGATPLMLAAVTGQLPLVQLLVEKHADMNKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDRGGRPSHRPPLPHSKARQPWSIPMLPDDKGGLKSWWSRMSNRFRKLKLMQTLPRGLAANQPLPFSDEPELALDSTMRAPPQDRTNHLGPPEAAHAAKDSGPGNPRREKDDVLLTTMLRNGAPFPRLPSDKLKAVIPPFLPPSSFELWSSDRSRTCPNGKADPMKTVLPPRASRAHPVGCVGTDGAAGRPVKFPSISRSPTSPASSGNFNHSPHSSGGASGVGSMSRLGGELHNRSGGSVDSVLSQIAAQRKKAAGLCEQKPPCQQSSPVGPATGSSPPELPASLLGSGSGSSNVTSSSKKLDPGKRPPSGTSATSKSTSPTLTPSPSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITDEDELTGILKKLSLEKYQPIFEEQEVDMEAFLTLTDGDLQELGIKTDGSRQQILAAISELNAGKGRERQILQETIHNFHSSFESSASNTRAPGNSPCMAGWVRPEETVSSRR
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Anks6 are the cause of polycystic kidney disease (cy). Heterozygous cy rats are characterized by progressive formation and enlargement of cysts in kidneys. {ECO:0000269|PubMed:16207829, ECO:0000269|PubMed:19324013, ECO:0000269|PubMed:26327442}.
uniprot
proteins
function
FUNCTION: Required for renal function. {ECO:0000269|PubMed:16207829}.
uniprot
proteins
mass_dalton
93809
uniprot
proteins
mutagenesis
MUTAGEN 129; /note="N->A: Decreased NEK8-binding, but no effect on INVS-binding; when associated with A-209."; /evidence="ECO:0000269|PubMed:23793029"; MUTAGEN 209; /note="N->A: Decreased NEK8-binding, but no effect on INVS-binding; when associated with A-129."; /evidence="ECO:0000269|PubMed:23793029"; MUTAGEN 433; /note="Q->R: No effect on interaction with INVS, NEK8 ANDNPHP3, nor on ciliary localization. Unable to rescue ANKS6 knockout in a heterologous system."; /evidence="ECO:0000269|PubMed:23793029
uniprot
proteins
post_translational_modification
PTM: Hydroxylated at Asn-129, most probably by HIF1AN. This hydroxylation results in decreased NEK8-binding. {ECO:0000269|PubMed:23793029}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16207829
uniprot
proteins
pubmed
19324013
uniprot
proteins
pubmed
23793029
uniprot
proteins
pubmed
25671767
uniprot
proteins
pubmed
26188091
uniprot
proteins
pubmed
26327442
uniprot
proteins
sequence_length
885
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q6GQX6}. Cytoplasm {ECO:0000269|PubMed:19324013}. Note=Localizes to the proximal region of the primary cilium in the presence of INVS. {ECO:0000250|UniProtKB:Q6GQX6}.
uniprot
proteins