Ptprs
entrez
19280
canonical
uniprot
B0V2N1
canonical
ensembl
ENSMUSG00000013236
resolver
ensp
ENSMUSP00000064048
resolver
ensp
ENSMUSP00000084038
resolver
ensp
ENSMUSP00000153134
resolver
ensp
ENSMUSP00000169647
resolver
genesymbol
Ptprs
resolver
uniprot
Q3TEC3
resolver
uniprot
Q3TQ52
resolver
uniprot
Q3TXC9
resolver
uniprot
Q4JFC7
resolver
uniprot
Q5XJV4
resolver
uniprot
Q64503
resolver
uniprot
Q64699
resolver
uniprot
Q7TT17
resolver
uniprot_entry
PTPRS_MOUSE
resolver
uniprot_entry
Q3TQ52_MOUSE
resolver
uniprot_sec
Q3TEC3
resolver
uniprot_sec
Q3TXC9
resolver
uniprot_sec
Q4JFC7
resolver
uniprot_sec
Q5XJV4
resolver
uniprot_sec
Q64503
resolver
uniprot_sec
Q64699
resolver
uniprot_sec
Q7TT17
resolver
amino_acid_sequence
MAPTWSPSVVSVVGPVGLFLVLLARGCLAEEPPRFIREPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIDFDESSGAVLRIQPLRTPRDENVYECVAQNSVGEITIHAKLTVLREDQLPPGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPVVTENTATSITVTWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAKSETSIGLSWSAPRQESVIKYELLFREGDRGREVGRTFDPTTAFVVEDLKPNTEYAFRLAARSPQGLGAFTAVVRQRTLQAKPSAPPQDVKCTSLRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPDPKEVNNIPPTTTQILLEALEKWTEYRVTAVAYTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPTPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDIMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPADAAEDPVLGYRLQFGREDAAPATLELAAWERRFAAPAHKGATYVFRLAARGRAGLGEEAAAALSIPEDAPRGFPQILGAAGNVSAGSVLLRWLPPVPAERNGAIIKYTVSVREAGAPGPATETELAAAAQPGAETALTLRGLRPETAYELRVRAHTRRGPGPFSPPLRYRLARDPVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTARTAFNMLSGKPSVAPKPDNDGFIVVYLPDGQSPVTVQNYFIVMVPLRKSRGGQFPVLLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSILPAVFHPGNQKQYGGFDNRGLEPGHRYVLFVLAVLQKNEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPITDMAEHMERLKANDSLKLSQEYESIDPGQQFTWEHSNLEANKPKNRYANVIAYDHSRVILQPLEGIMGSDYINANYVDGYRRQNAYIATQGPLPETFGDFWRMVWEQRSATVVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTMELATFCVRTFSLHKNGSSEKREVRHFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKTEKTVDVYGHVTLMRSQRNYMVQTEDQYGFIHEALLEAVGCGNTEVPARSLYTYIQKLAQVEPGEHVTGMELEFKRLASSKAHTSRFITASLPCNKFKNRLVNILPYESSRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRALWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGAPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKVLRTQRPAMVQTEDEYQFCFQAALEYLGSFDHYAT
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans (PubMed:19833921, PubMed:21454754, PubMed:22406547). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (PubMed:21454754). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection (PubMed:15797710, PubMed:19780196, PubMed:19833921, PubMed:21454754, PubMed:22406547, PubMed:22519304). Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2 (PubMed:21454754). Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb (PubMed:10080191). Functions as a tyrosine phosphatase (PubMed:7529177). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (PubMed:15797710). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120). {ECO:0000250|UniProtKB:F1NWE3, ECO:0000269|PubMed:10080191, ECO:0000269|PubMed:15797710, ECO:0000269|PubMed:19780196, ECO:0000269|PubMed:19833921, ECO:0000269|PubMed:21454754, ECO:0000269|PubMed:22406547, ECO:0000269|PubMed:26231120, ECO:0000269|PubMed:7529177}.
uniprot
proteins
mass_dalton
211904
uniprot
proteins
mutagenesis
MUTAGEN 68..72; /note="KKGKK->AAGAA: Abolishes binding to chondroitin sulfate proteoglycans. Abolishes receptor oligomerization via binding to large heparan sulfate proteoglycan structures."; /evidence="ECO:0000269|PubMed:19833921, ECO:0000269|PubMed:21454754
uniprot
proteins
post_translational_modification
PTM: A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 2A subfamily
uniprot
proteins
pubmed
10080191
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15797710
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19780196
uniprot
proteins
pubmed
19833921
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21454754
uniprot
proteins
pubmed
22027896
uniprot
proteins
pubmed
22406547
uniprot
proteins
pubmed
22519304
uniprot
proteins
pubmed
25385546
uniprot
proteins
pubmed
26231120
uniprot
proteins
pubmed
7529177
uniprot
proteins
sequence_length
1907
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26231120}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:21454754}. Perikaryon {ECO:0000269|PubMed:21454754}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q64605}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q64605}. Postsynaptic density {ECO:0000250|UniProtKB:Q64605}. Cell projection, neuron projection {ECO:0000269|PubMed:21454754}. Cell projection, growth cone {ECO:0000269|PubMed:21454754}. Note=Is rapidly internalized when dendritic cells are stimulated with the TLR9 ligand cytidine-phosphate-guanosine (CpG) (PubMed:26231120). Detected in a punctate pattern along neurites and axon growth cones (PubMed:21454754). {ECO:0000269|PubMed:21454754, ECO:0000269|PubMed:26231120}.
uniprot
proteins
transmembrane_region
TRANSMEM 1258..1278; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins