Cplx2
entrez
12890
canonical
uniprot
P84086
canonical
ensembl
ENSMUSG00000025867
resolver
ensembl
ENSMUSG00000112941
resolver
ensp
ENSMUSP00000026985
resolver
enst
ENSMUST00000026985
resolver
genesymbol
Cplx2
resolver
uniprot
O09056
resolver
uniprot
Q13329
resolver
uniprot
Q28184
resolver
uniprot
Q32KK4
resolver
uniprot
Q64386
resolver
uniprot_entry
CPLX2_MOUSE
resolver
uniprot_sec
O09056
resolver
uniprot_sec
Q13329
resolver
uniprot_sec
Q28184
resolver
uniprot_sec
Q32KK4
resolver
uniprot_sec
Q64386
resolver
amino_acid_sequence
MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAEREKVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTVLKYLPGPLQDMFKK
uniprot
proteins
function
FUNCTION: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:11163241, PubMed:23345244). Also involved in mast cell exocytosis (PubMed:11163241). Although not essential for development, seems critical for the acquisition of higher cognitive functions in the adult brain (PubMed:12915444). {ECO:0000269|PubMed:11163241, ECO:0000269|PubMed:12915444, ECO:0000269|PubMed:20346398, ECO:0000269|PubMed:23345244}.
uniprot
proteins
mass_dalton
15394
uniprot
proteins
protein_family
Complexin/synaphin family
uniprot
proteins
pubmed
11163241
uniprot
proteins
pubmed
12915444
uniprot
proteins
pubmed
15911881
uniprot
proteins
pubmed
16162394
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
20346398
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23345244
uniprot
proteins
pubmed
7553862
uniprot
proteins
pubmed
7635198
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:7635198}. Presynapse {ECO:0000250|UniProtKB:P84087}. Nucleus {ECO:0000250|UniProtKB:P84087}. Perikaryon {ECO:0000250|UniProtKB:P84087}. Note=Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation. {ECO:0000250|UniProtKB:P84087}.
uniprot
proteins