Slc27a5
entrez
79111
canonical
uniprot
Q9ES38
canonical
ensembl
ENSRNOG00000019626
resolver
ensembl
ENSRNOG00055016476
resolver
ensembl
ENSRNOG00060023871
resolver
ensembl
ENSRNOG00065031529
resolver
ensp
ENSRNOP00000026574
resolver
ensp
ENSRNOP00055022462
resolver
ensp
ENSRNOP00060034261
resolver
ensp
ENSRNOP00065044695
resolver
enst
ENSRNOT00000026575
resolver
enst
ENSRNOT00055027941
resolver
enst
ENSRNOT00060041356
resolver
enst
ENSRNOT00065054328
resolver
genesymbol
Slc27a5
resolver
genesymbol_syn
Acsb
resolver
genesymbol_syn
Fatp5
resolver
genesymbol_syn
Vlacsr
resolver
uniprot_entry
S27A5_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by mono-unsaturated fatty acids, palmitoleic acid and oleic acid and nonionic detergents, triton X-100 and polyethylene glycol hexadecyl ether (Brij 58). {ECO:0000269|PubMed:12454267}.
uniprot
proteins
amino_acid_sequence
MGVWKKLTFLLLSLLLLVGLGQPLWPAATALALRWFLGDPTCFVLLGLAFLGRPWISSWIPHWLSLAAAALTLSLLPPRPPPELRWLHKDVAFAFKLLFYGLNLRRRLNRHPPELFVDALEQQAQARPDQVALVCTGSEGCSITNRELNAKACQAAWALKAKLKEATIQEDKGATAILVLPSKSISALSVFLGLAKLGCPVAWINPHSRGMPLLHSVQSSGASVLIVDPDLQENLEEVLPKLLAENIRCFYLGHSSPTPGVEALGAALDAAPSDPVPAKLRANIKWKSPAIFIYTSGTTGLPKPAILSHERVIQMSNVLSFCGRTADDVVYNVLPLYHSMGLVLGVLGCLQLGATCVLAPKFSASRYWAECRQYSVTVVLYVGEVLRYLCNVPGQPEDKKHTVRFALGNGLRADVWENFQQRFGPIQIWELYGSTEGNVGLMNYVGHCGAVGKTSCFIRMLTPLELVQFDIETAEPVRDKQGFCIPVETGKPGLLLTKIRKNQPFLGYRGSQDETKRKLVANVRQVGDLYYNTGDVLALDQEGFFYFRDRLGDTFRWKGENVSTREVEGVLSILDFLEEVNVYGVTVPGCEGKVGMAAVKLAPGKTFDGQKLYQHVRSWLPAYATPHFIRIQDSLEITNTYKLVKSQLAREGFDVGVIADPLYILDNKAETFRSLMPDVYQAVCEGTWKL
uniprot
proteins
ec_number
6.2.1.-
uniprot
proteins
ec_number
6.2.1.3
uniprot
proteins
ec_number
6.2.1.7
uniprot
proteins
function
FUNCTION: Mediates the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes (By similarity). Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (By similarity). Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:12454267, PubMed:12951368). In particular, catalyzes the activation of the primary bile acid, chenodeoxycholic acid (PubMed:12454267, PubMed:12951368). Primary bile acid cholic acid and secondary bile acids (deoxycholic acid and lithocholic acid) are principal substrates too (By similarity). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (By similarity). Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity). {ECO:0000250|UniProtKB:Q4LDG0, ECO:0000250|UniProtKB:Q9Y2P5, ECO:0000269|PubMed:12454267, ECO:0000269|PubMed:12951368}.
uniprot
proteins
mass_dalton
76266
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
12454267
uniprot
proteins
pubmed
12951368
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
690
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y2P5}; Multi-pass membrane protein {ECO:0000255}. Microsome {ECO:0000269|PubMed:12951368}. Cell membrane {ECO:0000250|UniProtKB:Q4LDG0}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 56..76; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins