Tomm7
entrez
66169
canonical
uniprot
Q9D173
canonical
ensembl
ENSMUSG00000028998
resolver
ensp
ENSMUSP00000030851
resolver
enst
ENSMUST00000030851
resolver
genesymbol
Tomm7
resolver
uniprot_entry
TOM7_MOUSE
resolver
amino_acid_sequence
MVKLSKEAKQRLQQLFKGGQFAIRWGFIPLVIYLGFTRGADPGMPEPSVLSLLWG
uniprot
proteins
function
FUNCTION: Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity). {ECO:0000250|UniProtKB:Q9P0U1}.
uniprot
proteins
mass_dalton
6177
uniprot
proteins
mutagenesis
MUTAGEN 25; /note="W->R: Homozygous mice develop a rapidly progressing emaciation after 7-8 weeks of life, leading to sudden death at around 9 to 10 weeks of age. There is lipid accumulation in the liver. Tibial growth plates of mutant mice show a shortening of the growth plate."; /evidence="ECO:0000269|PubMed:36299998
uniprot
proteins
protein_family
Tom7 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
36299998
uniprot
proteins
sequence_length
55
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9P0U1}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9P0U1}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..36; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9P0U1
uniprot
proteins