Slc7a14
entrez
241919
canonical
uniprot
Q8BXR1
canonical
ensembl
ENSMUSG00000069072
resolver
ensp
ENSMUSP00000088803
resolver
ensp
ENSMUSP00000245323
resolver
ensp
ENSMUSP00000245325
resolver
enst
ENSMUST00000091259
resolver
genesymbol
Slc7a14
resolver
genesymbol_syn
Kiaa1613
resolver
uniprot
Q69ZE9
resolver
uniprot_entry
S7A14_MOUSE
resolver
uniprot_sec
Q69ZE9
resolver
amino_acid_sequence
MSGFLASLDPRRVQWGAAWYAMHSRILRTKPVESMLEGTGTTSAHGTKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHSISRWMVDTVGTLNGLGKGEESYPDLLALVIAVIVTIIVALGVKNSVGFNNVLNVLNLAVWVFIMIAGLFFINGKYWAEGQFLPHGWSGVLQGAATCFYAFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSMILTLMVPYYAIDTESPLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTETPVVACIVSGFLAALLSLLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGFVKFLSEEHTKKKEGILADCEKETCSPVSEGEEFSSPATNTCGAKNLPSLGDNEMLIGKSDKSAYNVNHPNYGTVDMTTGIEADESENIYLIKLKKLIGPRYYTMRIRLGLPGKMDRPTAATGHTVTICVLLLFILMFIFCSFIIFGSEYISGQSWWAILLVVLMMLLISVLVFVILQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVWCFVGMLIYFGYGIWNSTLEISAREQALHQSTYQRYDVDDPFSVEEGFSYATEGESQEDWGGPAEDKGFYYQQMSDAKANSRTSSKAKSKSKHKQNSEALIANDELDCSPE
uniprot
proteins
function
FUNCTION: Imports 4-aminobutanoate (GABA) into lysosomes. May act as a GABA sensor that regulates mTORC2-dependent INS signaling and gluconeogenesis. The transport mechanism and substrate selectivity remain to be elucidated. {ECO:0000269|PubMed:36640347}.
uniprot
proteins
mass_dalton
83984
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24670872
uniprot
proteins
pubmed
36640347
uniprot
proteins
sequence_length
771
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:36640347}; Multi-pass membrane protein {ECO:0000250}. Note=Exhibits a punctated pattern in the cytoplasm, which partially ovelaps with lysosomes. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..78; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 83..103; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 119..141; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 187..207; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 216..236; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 251..271; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 291..311; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 336..356; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 384..404; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 565..585; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 596..616; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 628..648; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 655..675; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins