Emc8
entrez
18117
canonical
uniprot
O70378
canonical
ensembl
ENSMUSG00000031819
resolver
ensp
ENSMUSP00000034277
resolver
enst
ENSMUST00000034277
resolver
genesymbol
Emc8
resolver
genesymbol_syn
Cox4al
resolver
genesymbol_syn
Cox4nb
resolver
genesymbol_syn
Noc4
resolver
uniprot
Q3TPU5
resolver
uniprot_entry
EMC8_MOUSE
resolver
uniprot_entry
Q3TPU5_MOUSE
resolver
amino_acid_sequence
MPGVKLTTQAYCKMVLHGAKYPHCAVNGLLVAERQRPRKEHPPGAGSHTLFVDCIPLFHGTLALTPMLEVALTLIDSWCKDNSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFGDAALIMVDNAKFTMDCAAPTIHVYEQHENRWRCRDPHHDYCEDWPEAQRISASLLDSRSYETLVDFDNHLDDIRSDWTNPEINKAVLHLC
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. {ECO:0000250|UniProtKB:O43402}.
uniprot
proteins
mass_dalton
23348
uniprot
proteins
protein_family
EMC8/EMC9 family
uniprot
proteins
pubmed
10337626
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
207
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43402}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43402}; Cytoplasmic side {ECO:0000250|UniProtKB:O43402}.
uniprot
proteins