Arhgdia
entrez
360678
canonical
uniprot
Q5XI73
canonical
genesymbol
Arhgdia
resolver
uniprot_entry
GDIR1_RAT
resolver
amino_acid_sequence
MAEQEPTAEQLAQIAAENEEDEHSVNYKPPAQKSIQEIQELDKDDESLRKYKEALLGRVAVSADPNVPNVIVTRLTLVCSTAPGPLELDLTGDLESFKKQSFVLKEGVEYRIKISFRVNREIVSGMKYIQHTYRKGVKIDKTDYMVGSYGPRAEEYEFLTPMEEAPKGMLARGSYNIKSRFTDDDKTDHLSWEWNLTIKKEWKD
uniprot
proteins
function
FUNCTION: Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000250|UniProtKB:P52565, ECO:0000250|UniProtKB:Q99PT1, ECO:0000269|PubMed:20696765}.
uniprot
proteins
mass_dalton
23407
uniprot
proteins
protein_family
Rho GDI family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19343716
uniprot
proteins
pubmed
20696765
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
25961457
uniprot
proteins
sequence_length
204
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19343716}.
uniprot
proteins