C4b
entrez
12268
canonical
uniprot
P01029
canonical
ensembl
ENSMUSG00000073418
resolver
ensp
ENSMUSP00000069418
resolver
ensp
ENSMUSP00000284704
resolver
enst
ENSMUST00000069507
resolver
genesymbol
C4b
resolver
genesymbol_syn
C4
resolver
uniprot
E9QKK7
resolver
uniprot
O70346
resolver
uniprot
Q31201
resolver
uniprot
Q3TYN1
resolver
uniprot
Q3TYY1
resolver
uniprot
Q3TZC9
resolver
uniprot
Q61372
resolver
uniprot
Q61859
resolver
uniprot
Q62353
resolver
uniprot
Q6NWV8
resolver
uniprot_entry
CO4B_MOUSE
resolver
uniprot_entry
Q3TYN1_MOUSE
resolver
uniprot_sec
E9QKK7
resolver
uniprot_sec
O70346
resolver
uniprot_sec
Q31201
resolver
uniprot_sec
Q3TYY1
resolver
uniprot_sec
Q3TZC9
resolver
uniprot_sec
Q61372
resolver
uniprot_sec
Q61859
resolver
uniprot_sec
Q62353
resolver
uniprot_sec
Q6NWV8
resolver
amino_acid_sequence
MRLLWGLAWVFSFCASSLQKPRLLLFSPSVVNLGTPLSVGVQLLDAPPGQEVKGSVFLRNPKGGSCSPKKDFKLSSGDDFVLLSLEVPLEDVRSCGLFDLRRAPHIQLVAQSPWLRNTAFKATETQGVNLLFSSRRGHIFVQTDQPIYNPGQRVRYRVFALDQKMRPSTDFLTITVENSHGLRVLKKEIFTSTSIFQDAFTIPDISEPGTWKISARFSDGLESNRSTHFEVKKYVLPNFEVKITPWKPYILMVPSNSDEIQLDIQARYIYGKPVQGVAYTRFALMDEQGKRTFLRGLETQAKLVEGRTHISISKDQFQAALDKINIGVRDLEGLRLYAATAVIESPGGEMEEAELTSWRFVSSAFSLDLSRTKRHLVPGAHFLLQALVQEMSGSEASNVPVKVSATLVSGSDSQVLDIQQSTNGIGQVSISFPIPPTVTELRLLVSAGSLYPAIARLTVQAPPSRGTGFLSIEPLDPRSPSVGDTFILNLQPVGIPAPTFSHYYYMIISRGQIMAMGREPRKTVTSVSVLVDHQLAPSFYFVAYFYHQGHPVANSLLINIQSRDCEGKLQLKVDGAKEYRNADMMKLRIQTDSKALVALGAVDMALYAVGGRSHKPLDMSKVFEVINSYNVGCGPGGGDDALQVFQDAGLAFSDGDRLTQTREDLSCPKEKKSRQKRNVNFQKAVSEKLGQYSSPDAKRCCQDGMTKLPMKRTCEQRAARVPQQACREPFLSCCKFAEDLRRNQTRSQAHLARNNHNMLQEEDLIDEDDILVRTSFPENWLWRVEPVDSSKLLTVWLPDSMTTWEIHGVSLSKSKGLCVAKPTRVRVFRKFHLHLRLPISIRRFEQFELRPVLYNYLNDDVAVSVHVTPVEGLCLAGGGMMAQQVTVPAGSARPVAFSVVPTAAANVPLKVVARGVFDLGDAVSKILQIEKEGAIHREELVYNLDPLNNLGRTLEIPGSSDPNIVPDGDFSSLVRVTASEPLETMGSEGALSPGGVASLLRLPQGCAEQTMIYLAPTLTASNYLDRTEQWSKLSPETKDHAVDLIQKGYMRIQQFRKNDGSFGAWLHRDSSTWLTAFVLKILSLAQEQVGNSPEKLQETASWLLAQQLGDGSFHDPCPVIHRAMQGGLVGSDETVALTAFVVIALHHGLDVFQDDDAKQLKNRVEASITKANSFLGQKASAGLLGAHAAAITAYALTLTKASEDLRNVAHNSLMAMAEETGEHLYWGLVLGSQDKVVLRPTAPRSPTEPVPQAPALWIETTAYALLHLLLREGKGKMADKAASWLTHQGSFHGAFRSTQDTVVTLDALSAYWIASHTTEEKALNVTLSSMGRNGLKTHGLHLNNHQVKGLEEELKFSLGSTISVKVEGNSKGTLKILRTYNVLDMKNTTCQDLQIEVKVTGAVEYAWDANEDYEDYYDMPAADDPSVPLQPVTPLQLFEGRRSRRRREAPKVVEEQESRVQYTVCIWRNGKLGLSGMAIADITLLSGFHALRADLEKLTSLSDRYVSHFETDGPHVLLYFDSVPTTRECVGFGASQEVVVGLVQPSSAVLYDYYSPDHKCSVFYAAPTKSQLLATLCSGDVCQCAEGKCPRLLRSLERRVEDKDGYRMRFACYYPRVEYGFTVKVLREDGRAAFRLFESKITQVLHFRKDTMASIGQTRNFLSRASCRLRLEPNKEYLIMGMDGETSDNKGDPQYLLDSNTWIEEMPSEQMCKSTRHRAACFQLKDFLMEFSSRGCQV
uniprot
proteins
function
FUNCTION: Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. {ECO:0000250|UniProtKB:A0AAQ4VMX2}.; FUNCTION: [Complement C4b-B]: Non-enzymatic component of C3 and C5 convertases. Generated following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway), it covalently attaches to the surface of pathogens, where it acts as an opsonin that marks the surface of antigens for removal. It then recruits the serine protease complement C2b to form the C3 and C5 convertases, which cleave and activate C3 and C5, respectively, the next components of the complement pathways. Complement C4b-A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while complement C4b-B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. {ECO:0000250|UniProtKB:P0C0L4}.; FUNCTION: [C4a anaphylatoxin]: Putative humoral mediator released following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway). While it is strongly similar to anaphylatoxins, its role is unclear. Was reported to act as a mediator of local inflammatory process; however these effects were probably due to contamination with C3a and/C5a anaphylatoxins in biological assays. {ECO:0000250|UniProtKB:P0C0L4}.
uniprot
proteins
mass_dalton
192915
uniprot
proteins
post_translational_modification
PTM: Prior to secretion, the single-chain precursor is enzymatically cleaved by plasminogen (PLG) to yield non-identical chains alpha, beta and gamma. During activation of the complement systems, the alpha chain is cleaved into C4a and C4b by different proteases depending on the complement pathway: C4b stays linked to the beta and gamma chains, while C4a is released in the plasma. The alpha chain is cleaved by C1S to generate C4a and C4b following activation by the classical complement system. The alpha chain is cleaved to generate C4a and C4b by MASP2 following activation by the lectin complement system. The alpha chain is cleaved by GZMK to generate C4a and C4b following activation by the GZMK complement system. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase. The proteolytic cleavages often are incomplete so that many structural forms can be found in plasma. {ECO:0000250|UniProtKB:P0C0L4}.; PTM: [Complement C4b-B]: Upon activation, the internal thioester bond reacts with carbohydrate antigens on the target surface to form amide or ester bonds, leading to covalent association with the surface of pathogens. {ECO:0000250|UniProtKB:P0C0L4}.; PTM: [Complement C4b-B]: Complement C4b interacts with complement C3b via a thioester linkage. {ECO:0000250|UniProtKB:P0C0L4}.
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17330941
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2387317
uniprot
proteins
pubmed
2459207
uniprot
proteins
pubmed
2777798
uniprot
proteins
pubmed
2993295
uniprot
proteins
pubmed
2997024
uniprot
proteins
pubmed
3008092
uniprot
proteins
pubmed
3464002
uniprot
proteins
pubmed
3856857
uniprot
proteins
pubmed
3862104
uniprot
proteins
pubmed
6149581
uniprot
proteins
pubmed
6192448
uniprot
proteins
pubmed
6208559
uniprot
proteins
sequence_length
1738
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C0L4}.; SUBCELLULAR LOCATION: [C4a anaphylatoxin]: Secreted {ECO:0000250|UniProtKB:P0C0L4}.; SUBCELLULAR LOCATION: [Complement C4b-B]: Secreted {ECO:0000250|UniProtKB:P0C0L4}. Cell surface {ECO:0000250|UniProtKB:P0C0L4}. Note=Covalently associated with the surface of pathogens: the internal thioester bond reacts with carbohydrate antigens on the target surface to form amide or ester bonds. {ECO:0000250|UniProtKB:P0C0L4}.
uniprot
proteins