PCIF1
entrez
63935
canonical
uniprot
Q9H4Z3
canonical
ensembl
ENSG00000100982
resolver
ensp
ENSP00000361486
resolver
ensp
ENSP00000574091
resolver
ensp
ENSP00000574098
resolver
ensp
ENSP00000574099
resolver
enst
ENST00000372409
resolver
enst
ENST00000904032
resolver
enst
ENST00000904039
resolver
enst
ENST00000904040
resolver
genesymbol
PCIF1
resolver
genesymbol_syn
C20orf67
resolver
genesymbol_syn
CAPAM
resolver
genesymbol_syn
PPP1R121
resolver
hgnc
HGNC:16200
resolver
uniprot
E1P5P1
resolver
uniprot
Q54AB9
resolver
uniprot
Q9NT85
resolver
uniprot_entry
CAPAM_HUMAN
resolver
uniprot_sec
E1P5P1
resolver
uniprot_sec
Q54AB9
resolver
uniprot_sec
Q9NT85
resolver
activity_regulation
ACTIVITY REGULATION: Cap-specific adenosine methyltransferase activity is inhibited by zinc. {ECO:0000269|PubMed:33428944}.
uniprot
proteins
amino_acid_sequence
MANENHGSPREEASLLSHSPGTSNQSQPCSPKPIRLVQDLPEELVHAGWEKCWSRRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNATPLPQDSSLVETPPAENKPRKRQLSEEQPSGNGVKKPKIEIPVTPTGQSVPSSPSIPGTPTLKMWGTSPEDKQQAALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGSDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKDHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAILKENNISEEVEAPEVEPRLVYCYPVRLAVSAPPMPSVEMHMENNVVCIRYKGEMVKVSRNYFSKLWLLYRYSCIDDSAFERFLPRVWCLLRRYQMMFGVGLYEGTGLQGSLPVHVFEALHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFAPLSGSFEANPPFCEELMDAMVSHFERLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLILPAFEHEYRSGSQHICKKEEMHYKAVHNTAVLFLQNDPGFAKWAPTPERLQELSAAYRQSGRSHSSGSSSSSSSEAKDRDSGREQGPSREPHPT
uniprot
proteins
ec_number
2.1.1.62
uniprot
proteins
function
FUNCTION: Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659, PubMed:33428944). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178). {ECO:0000269|PubMed:30467178, ECO:0000269|PubMed:30487554, ECO:0000269|PubMed:31279658, ECO:0000269|PubMed:31279659, ECO:0000269|PubMed:33428944}.
uniprot
proteins
mass_dalton
80670
uniprot
proteins
mutagenesis
MUTAGEN 553..556; /note="NPPF->APPA,SPPG: Abolishes formation of N(6),2'-O-dimethyladenosine cap (m6A(m))."; /evidence="ECO:0000269|PubMed:31279658, ECO:0000269|PubMed:31279659"; MUTAGEN 553; /note="N->A: Strongly reduced formation of N(6),2'-O-dimethyladenosine cap (m6A(m))."; /evidence="ECO:0000269|PubMed:30467178, ECO:0000269|PubMed:30487554"; MUTAGEN 556; /note="F->G: Strongly reduced formation of N(6),2'-O-dimethyladenosine cap (m6A(m))."; /evidence="ECO:0000269|PubMed:30487554
uniprot
proteins
protein_family
CAPAM family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12565871
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18294453
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30467178
uniprot
proteins
pubmed
30487554
uniprot
proteins
pubmed
31279658
uniprot
proteins
pubmed
31279659
uniprot
proteins
pubmed
33428944
uniprot
proteins
sequence_length
704
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12565871, ECO:0000269|PubMed:18294453, ECO:0000269|PubMed:31279659}.
uniprot
proteins