Coq8a
entrez
67426
canonical
uniprot
Q60936
canonical
ensembl
ENSMUSG00000026489
resolver
ensp
ENSMUSP00000027766
resolver
ensp
ENSMUSP00000128290
resolver
ensp
ENSMUSP00000262543
resolver
genesymbol
Coq8a
resolver
genesymbol_syn
Adck3
resolver
genesymbol_syn
Cabc1
resolver
uniprot
Q8K0M1
resolver
uniprot
Q9D657
resolver
uniprot
Q9DBR5
resolver
uniprot
Q9JHR3
resolver
uniprot_entry
COQ8A_MOUSE
resolver
uniprot_sec
Q8K0M1
resolver
uniprot_sec
Q9D657
resolver
uniprot_sec
Q9DBR5
resolver
uniprot_sec
Q9JHR3
resolver
activity_regulation
ACTIVITY REGULATION: Autoinhibited by the N-terminal domain, containing the KxGQ motif, that completely occludes the typical substrate binding pocket. Nucleotide-binding relieves inhibition. {ECO:0000250|UniProtKB:Q8NI60}.
uniprot
proteins
amino_acid_sequence
MAAMLGDAIMVAKGLAKLTQAAVETHLQNLGLGGELLLAARALQSTAVEQFSMVFGKVQGQDKHEDSYATENFEDLEAEVQFSTPQAAGTSLDFSAASSLDQSLSPSHSQGPAPAYASSGPFREAGLPGQATSPMGRVNGRLFVDHRDLFLANGIQRRSFHQDQSSVGGLTAEDIEKARQAKARPESKPHKQMLSERARERKVPVTRIGRLANFGGLAVGLGIGALAEVAKKSLRSENSTGKKAVLDSSPFLSEANAERIVSTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMTKTLNSDLGPHWRDKLEYFEERPFAAASIGQVHLARMKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELTLECDYQREAAYAKKFRELLKDHPFFYVPEIVDELCSPHVLTTELISGFPLDQAEGLSQEVRNEICYNILVLCLRELFEFHVMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQVIRAAADQDREAVLKKSIEMKFLTGYEVKAMEDAHLDAILILGEAFASEEPFDFGTQSTTEKIHNLIPVMLKHRLIPPPEETYSLHRKMGGSFLICSKLKARFPCKAMFEEAYSNYCRMKSGLQ
uniprot
proteins
ec_number
2.7.-.-
uniprot
proteins
function
FUNCTION: Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:27499294). Its substrate specificity is still unclear: may act as a protein kinase that mediates phosphorylation of COQ3 (By similarity). According to other reports, acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (By similarity). However, the small molecule kinase activity was not confirmed by another publication (By similarity). Shows an unusual selectivity for binding ADP over ATP (By similarity). {ECO:0000250|UniProtKB:Q8NI60, ECO:0000250|UniProtKB:Q96D53, ECO:0000269|PubMed:27499294}.
uniprot
proteins
mass_dalton
71743
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000250|UniProtKB:Q8NI60}.
uniprot
proteins
protein_family
ADCK protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27499294
uniprot
proteins
sequence_length
645
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250|UniProtKB:Q8NI60}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 211..227; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins