Akt1s1
entrez
67605
canonical
uniprot
Q9D1F4
canonical
ensembl
ENSMUSG00000011096
resolver
ensp
ENSMUSP00000049764
resolver
ensp
ENSMUSP00000103512
resolver
ensp
ENSMUSP00000103514
resolver
ensp
ENSMUSP00000204025
resolver
ensp
ENSMUSP00000204031
resolver
ensp
ENSMUSP00000204041
resolver
ensp
ENSMUSP00000204043
resolver
ensp
ENSMUSP00000204050
resolver
ensp
ENSMUSP00000204051
resolver
ensp
ENSMUSP00000204053
resolver
enst
ENSMUST00000054343
resolver
enst
ENSMUST00000107880
resolver
enst
ENSMUST00000107882
resolver
genesymbol
Akt1s1
resolver
genesymbol_syn
Pras
resolver
uniprot
A2RT52
resolver
uniprot
E9QKI5
resolver
uniprot_entry
AKTS1_MOUSE
resolver
uniprot_entry
E9QKI5_MOUSE
resolver
uniprot_sec
A2RT52
resolver
amino_acid_sequence
MASGRPEELWEAVVGAAERFQARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIAQAHRAATATRPPGPPPAPQPPSPAPSPPPRPALAREDEEEDEDEPTETETSGERLGGSDNGGLFMMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPTACPQPPATALPTQQYAKSLPVSVPVWAFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLPRPRLNTSDFQKLKRKY
uniprot
proteins
function
FUNCTION: Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (By similarity). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (By similarity). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (By similarity). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (By similarity). May also play a role in nerve growth factor-mediated neuroprotection (PubMed:14973226, PubMed:16397181). {ECO:0000250|UniProtKB:Q96B36, ECO:0000269|PubMed:14973226, ECO:0000269|PubMed:16397181}.
uniprot
proteins
mass_dalton
27483
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by AKT1; phosphorylation takes place in response to insulin treatment and promotes AKT1S1 interaction with 14-3-3 proteins, leading to relieve its inhibitor activity (By similarity). Phosphorylated by MTOR following mTORC1 activation, inhibiting AKT1S1 inhibitor activity: phosphorylation by MTOR probably serves as a feedback loop that relieves inhibition from AKT1S1 in response to mTORC1 inactivation (By similarity). Phosphorylation at Thr-247 by DYRK3 relieves inhibitory function on mTORC1 (By similarity). {ECO:0000250|UniProtKB:Q96B36}.
uniprot
proteins
pubmed
14973226
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16397181
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:14973226}. Note=Found in the cytosolic fraction of the brain (PubMed:14973226). Colocalizes with cortical neurons following ischemic/reperfusion injury (PubMed:14973226). {ECO:0000269|PubMed:14973226}.
uniprot
proteins