Med8
entrez
80509
canonical
uniprot
Q9D7W5
canonical
ensembl
ENSMUSG00000006392
resolver
ensp
ENSMUSP00000019229
resolver
ensp
ENSMUSP00000081346
resolver
ensp
ENSMUSP00000101992
resolver
ensp
ENSMUSP00000243086
resolver
enst
ENSMUST00000019229
resolver
enst
ENSMUST00000084319
resolver
enst
ENSMUST00000106384
resolver
genesymbol
Med8
resolver
genesymbol_syn
MED8
resolver
uniprot
F7CMA0
resolver
uniprot
F8WIC6
resolver
uniprot
Q3UGB4
resolver
uniprot
Q99LM4
resolver
uniprot
Q9CY05
resolver
uniprot
Q9DAY7
resolver
uniprot
Q9JJ84
resolver
uniprot_entry
F7CMA0_MOUSE
resolver
uniprot_entry
F8WIC6_MOUSE
resolver
uniprot_entry
MED8_MOUSE
resolver
uniprot_entry
Q9CY05_MOUSE
resolver
uniprot_entry
Q9DAY7_MOUSE
resolver
uniprot_sec
Q3UGB4
resolver
uniprot_sec
Q99LM4
resolver
uniprot_sec
Q9JJ84
resolver
amino_acid_sequence
MQREEKQLEASLDALLNQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPGDTNALVAAVAFGKGLSNWRPSGSSGPGQPGQPGAGTILAGASGLPQVQMPGAPNQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQR
uniprot
proteins
function
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
29199
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
Mediator complex subunit 8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins