Pim3
entrez
64534
canonical
uniprot
O70444
canonical
ensembl
ENSRNOG00000029698
resolver
ensp
ENSRNOP00000072553
resolver
genesymbol
Pim3
resolver
genesymbol_syn
Kid1
resolver
uniprot
Q4V8M2
resolver
uniprot_entry
PIM3_RAT
resolver
uniprot_entry
Q4V8M2_RAT
resolver
amino_acid_sequence
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKVYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGMAVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHNCGVVHRDIKDENLLVDLRSGELKLIDFGSGAVLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLFFRRRVSPECQQLIEWCLSLRPSERPSLDQIAAHPWMLGTEGSVPENCDLRLCALDTDDGASTTSSSESL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
36002
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to proteasomal degradation. {ECO:0000250}.; PTM: Phosphorylated. Interaction with PPP2CA promotes dephosphorylation (By similarity). Autophosphorylated (in vitro). {ECO:0000250}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
PIM subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
9632723
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins