PGLYRP1
entrez
8993
canonical
uniprot
O75594
canonical
ensembl
ENSG00000008438
resolver
ensp
ENSP00000008938
resolver
enst
ENST00000008938
resolver
genesymbol
PGLYRP1
resolver
genesymbol_syn
PGLYRP
resolver
genesymbol_syn
PGRP
resolver
genesymbol_syn
TNFSF3L
resolver
hgnc
HGNC:8904
resolver
uniprot
Q4VB36
resolver
uniprot_entry
PGRP1_HUMAN
resolver
uniprot_sec
Q4VB36
resolver
amino_acid_sequence
MSRRSMLLAWALPSLLRLGAAQETEDPACCSPIVPRNEWKALASECAQHLSLPLRYVVVSHTAGSSCNTPASCQQQARNVQHYHMKTLGWCDVGYNFLIGEDGLVYEGRGWNFTGAHSGHLWNPMSIGISFMGNYMDRVPTPQAIRAAQGLLACGVAQGALRSNYVLKGHRDVQRTLSPGNQLYHLIQNWPHYRSP
uniprot
proteins
function
FUNCTION: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity (PubMed:9707603). Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane (PubMed:21247889, PubMed:26183779). In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement (PubMed:26654597). Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system (PubMed:30713770). Also promotes the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity (PubMed:28977785, PubMed:29083508). Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor (PubMed:25595774, PubMed:28977785). {ECO:0000269|PubMed:21247889, ECO:0000269|PubMed:25595774, ECO:0000269|PubMed:26183779, ECO:0000269|PubMed:26654597, ECO:0000269|PubMed:28977785, ECO:0000269|PubMed:29083508, ECO:0000269|PubMed:30713770, ECO:0000269|PubMed:9707603}.
uniprot
proteins
mass_dalton
21731
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. N-glycosylation is required for bactericidal activity. {ECO:0000269|PubMed:16354652}.
uniprot
proteins
protein_family
N-acetylmuramoyl-L-alanine amidase 2 family
uniprot
proteins
pubmed
11461926
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15769462
uniprot
proteins
pubmed
16354652
uniprot
proteins
pubmed
21247889
uniprot
proteins
pubmed
25595774
uniprot
proteins
pubmed
26183779
uniprot
proteins
pubmed
26654597
uniprot
proteins
pubmed
28977785
uniprot
proteins
pubmed
29083508
uniprot
proteins
pubmed
30713770
uniprot
proteins
pubmed
9707603
uniprot
proteins
sequence_length
196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16354652}. Cytoplasmic granule {ECO:0000250}.
uniprot
proteins