Slc39a6
entrez
291733
canonical
uniprot
Q4V887
canonical
ensembl
ENSRNOG00000028703
resolver
ensembl
ENSRNOG00055018240
resolver
ensembl
ENSRNOG00060012035
resolver
ensembl
ENSRNOG00065015434
resolver
ensp
ENSRNOP00000034256
resolver
ensp
ENSRNOP00055024887
resolver
ensp
ENSRNOP00060016058
resolver
ensp
ENSRNOP00065020120
resolver
enst
ENSRNOT00000036306
resolver
enst
ENSRNOT00055030902
resolver
enst
ENSRNOT00060020400
resolver
enst
ENSRNOT00065025611
resolver
genesymbol
Slc39a6
resolver
genesymbol_syn
Zip6
resolver
uniprot_entry
S39A6_RAT
resolver
amino_acid_sequence
MATNLSVIMILTFALWVTNPLHELQSTAAFSQTTEKINSNWESGINVDVAVTMQRHHLQQLFYRYGENDSLSVEGFRKLLQNIGIDKIKRVHIHHDHERHSDHERHSDHERHSHRGHAAAGKNSRKAFCPDLDSDNSGKNPNTSQGKGSRPAEHVNGRRNGKESASSSEVTSAVYNTVSEGTHFLETIETPKPGRRTKDINPSTPPSITEKSRVGRLSRLARRKGNDSVSEPRKSFMYSRTSNDNIQECFNATKLLTSHGMSVQALLNATEFNYLCPAIINQIDARSCLIHTASEKKAEIPPKTYSLQIAWLGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSFLVALAVGTLSGDALLHLLPHSHASHHHSHSHEEPAMEMKRGPLFSHLSAQNLEESSYFDSTWKGLTALGGLYFMFLVEHVLTLIKQFKDKKKKNQKKPENDEDVESKKQLSKYESQLSTNEEKVDTGERPESYLQADSQEPSPFDSQQPTLLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHHILHHHHHQNHHPHSHSQRYSREELKDAGIATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSSGLSTSVAVFCHELPHELGDFAVLLKAGMTVKQAVLYNALSAMLAYLGMATGIFIGHYAENVSMWIFALTAGLFMYVALVDMVPEMLHNDASDHGCSRWGYFFLQNAGILLGFGIMLLISIFEHKIVFRINF
uniprot
proteins
function
FUNCTION: Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (By similarity). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essential role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes. Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (By similarity). {ECO:0000250|UniProtKB:Q13433, ECO:0000250|UniProtKB:Q8C145}.
uniprot
proteins
mass_dalton
83231
uniprot
proteins
post_translational_modification
PTM: Cleaved on the N-terminus before locating to the plasma membrane. {ECO:0000250|UniProtKB:Q13433}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q13433}.; PTM: Phosphorylated by ZAP70 in response to TCR stimulation leading to its activation. {ECO:0000250|UniProtKB:Q13433}.
uniprot
proteins
protein_family
ZIP transporter (TC 2.A.5) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15867272
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
741
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15867272}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13433}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:Q13433}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13433}. Membrane raft {ECO:0000250|UniProtKB:Q13433}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:15867272}. Note=Localizes to lipid rafts in T cells and is recruited into the immunological synapse in response to TCR stimulation (By similarity). In the choroid plexus is limited to the apical membrane in epithelial cells (PubMed:15867272). {ECO:0000250|UniProtKB:Q13433, ECO:0000269|PubMed:15867272}.
uniprot
proteins
transmembrane_region
TRANSMEM 312..332; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 342..362; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 410..430; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 644..664; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 673..693; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 711..731; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins