Ddx21
entrez
317399
canonical
uniprot
Q3B8Q1
canonical
ensembl
ENSRNOG00000043099
resolver
ensembl
ENSRNOG00055014660
resolver
ensembl
ENSRNOG00060007562
resolver
ensembl
ENSRNOG00065003346
resolver
ensp
ENSRNOP00000063494
resolver
ensp
ENSRNOP00055020554
resolver
ensp
ENSRNOP00060009446
resolver
ensp
ENSRNOP00065003392
resolver
enst
ENSRNOT00000068184
resolver
enst
ENSRNOT00055025138
resolver
enst
ENSRNOT00060012476
resolver
enst
ENSRNOT00065004766
resolver
genesymbol
Ddx21
resolver
genesymbol_syn
Ddx21a
resolver
uniprot_entry
DDX21_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Acetylation inhibits the helicase activity. {ECO:0000250|UniProtKB:Q9NR30}.
uniprot
proteins
amino_acid_sequence
MPGKLRSASKSESEGTEESMETLQKPSEKKTRKEKPKSKTDEATEGVEEAASSKVKAVKKKGPSEDDVGPPKSKKAKKQEEEPQDDPASKSKTSKKKKEPLEKKAPSAKTKEMKAEEPSEEEADAPKPKKTKKGKEANGDVGEKSPGLKNGLSHPKPDSSSTQAPGEESETEKEIPVEQKEGAFSNFPISEETVKLLKARGVNFLFPIQAKTFHHVYSGKDLIAQARTGTGKTFSFAIPLIEKLQGGLQERKRGRAPQVLVLAPTRELANQVSKDFSDITKKLSVACFYGGTPYGGQIERMRSGIDILVGTPGRIKDHLQNGKLDLTKLKHVVLDEVDQMLDMGFADQVEEILCVAYKKDSEDNPQTLLFSATCPHWVFNVAKKYMKSTYEQVDLIGKKTQKAAITVEHLAIKCHWTERAAVIGDVIRVYSGHQGRTIIFCETKKDAQELSQNTCIKQDAQSLHGDIPQKQREITLKGFRNGNFGVLVATNVAARGLDIPEVDLVVQSCPPKDVESYIHRSGRTGRAGRTGVCICFYQHKEEYQLAQVEQKAGIKFKRIGVPSATEIIKASSKDAIRLLDSVPPTAIGHFKQSAEKLIEEKGAVEALAAALAHISGATSVDQRSLINSQAGFVTMILRCSVEMPNISYAWKELKEQLGESIDAKVKGMVFLKGKLGVCFDVRTEAVTEIKEKWHDSRRWQLTVATEQPELEGPPEGYRGGRGQRDGSRGSFRGQRGGSRNFRGQGQRGGSRNFRGQRPGGGNKSNRSPNKGQKRSFSKAFGQ
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes. In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes. Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77'. Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases. Involved in rRNA processing. May bind to specific miRNA hairpins (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000250|UniProtKB:Q9NR30}.
uniprot
proteins
mass_dalton
85966
uniprot
proteins
post_translational_modification
PTM: Acetylation by CREBBP/CBP inhibits the helicase activity. Deacetylation by SIRT7 promotes the helicase activity and overcomes R-loop-mediated stalling of RNA polymerases. {ECO:0000250|UniProtKB:Q9NR30}.
uniprot
proteins
protein_family
DDX21/DDX50 subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
782
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9NR30}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9NR30}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JIK5}. Mitochondrion {ECO:0000250|UniProtKB:Q9JIK5}. Note=Present both in nucleolus and nucleoplasm. Interaction with JUN promotes translocation from the nucleolus to the nucleoplasm. Interaction with WDR46 is required for localization to the nucleolus. Colocalizes in the cytosol with DDX1, DHX36 and TICAM1. The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) RNA ligand stimulation (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000250|UniProtKB:Q9NR30}.
uniprot
proteins