FBXO24
entrez
26261
canonical
uniprot
O75426
canonical
ensembl
ENSG00000106336
resolver
ensp
ENSP00000241071
resolver
ensp
ENSP00000416558
resolver
ensp
ENSP00000420239
resolver
ensp
ENSP00000553093
resolver
genesymbol
FBXO24
resolver
genesymbol_syn
FBX24
resolver
hgnc
HGNC:13595
resolver
uniprot
A4D2D3
resolver
uniprot
A4D2D4
resolver
uniprot
B4DX91
resolver
uniprot
B4DY42
resolver
uniprot
Q9H0G1
resolver
uniprot_entry
A4D2D3_HUMAN
resolver
uniprot_entry
FBX24_HUMAN
resolver
uniprot_sec
A4D2D4
resolver
uniprot_sec
B4DX91
resolver
uniprot_sec
B4DY42
resolver
uniprot_sec
Q9H0G1
resolver
amino_acid_sequence
MGEKAVPLLRRRRVKRSCPSCGSELGVEEKRGKGNPISIQLFPPELVEHIISFLPVRDLVALGQTCRYFHEVCDGEGVWRRICRRLSPRLQDQGSGVRPWKRAAILNYTKGLYFQAFGGRRRCLSKSVAPLLAHGYRRFLPTKDHVFILDYVGTLFFLKNALVSTLGQMQWKRACRYVVLCRGAKDFASDPRCDTVYRKYLYVLATREPQEVVGTTSSRACDCVEVYLQSSGQRVFKMTFHHSMTFKQIVLVGQETQRALLLLTEEGKIYSLVVNETQLDQPRSYTVQLALRKVSHYLPHLRVACMTSNQSSTLYVTDQGGVYFEVHTPGVYRDLFGTLQAFDPLDQQMPLALSLPAKILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVCYLQRPITLWCGLNHSLVLSQSSEFSKELLGCGCGAGGRLPGWPKGSASFVKLQVKVPLCACALCATRECLYILSSHDIEQHAPYRHLPASRVVGTPEPSLGARAPQDPGGMAQACEEYLSQIHSCQTLQDRTEKMKEIVGWMPLMAAQKDFFWEALDMLQRAEGGGGGVGPPAPET
uniprot
proteins
function
FUNCTION: Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Specifically recognizes the deacetylated form of nucleoside diphosphate kinase A/NME1 and targets it for ubiquitin-mediated degradation (PubMed:25582197). Functions as a key regulator of cell proliferation by targeting PRMT6 for ubiquitination and proteasomal degradation, leading to cell cycle inhibition (PubMed:32828318). Also mediates 'Lys-6'-linked polyubiquitination of the mitochondrial S-adenosylmethionine transporter SLC25A26, targeting it for degradation and thereby maintaining mitochondrial function during spermiogenesis (By similarity). Promotes ubiquitination and degradation of mitochondrial aspartyl-tRNA synthetase DARS2, contributing to immunosuppressive activity (PubMed:39039092). In the nucleus, targets FOXK2 for ubiquitin-mediated degradation, a process that critically modulates mitochondrial respiration and cellular bioenergetics in lung epithelial cells (PubMed:38735474). {ECO:0000250|UniProtKB:Q9D417, ECO:0000269|PubMed:25582197, ECO:0000269|PubMed:32828318, ECO:0000269|PubMed:38735474, ECO:0000269|PubMed:39039092}.
uniprot
proteins
mass_dalton
64889
uniprot
proteins
pubmed
10531035
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25582197
uniprot
proteins
pubmed
32828318
uniprot
proteins
pubmed
38735474
uniprot
proteins
pubmed
39039092
uniprot
proteins
sequence_length
580
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:39039092}. Nucleus {ECO:0000269|PubMed:38735474}.
uniprot
proteins