MPP2
entrez
4355
canonical
uniprot
Q14168
canonical
ensembl
ENSG00000108852
resolver
ensp
ENSP00000269095
resolver
ensp
ENSP00000366389
resolver
ensp
ENSP00000428136
resolver
ensp
ENSP00000428182
resolver
ensp
ENSP00000428286
resolver
ensp
ENSP00000430540
resolver
ensp
ENSP00000438012
resolver
ensp
ENSP00000478528
resolver
ensp
ENSP00000480071
resolver
ensp
ENSP00000551488
resolver
ensp
ENSP00000551491
resolver
ensp
ENSP00000637352
resolver
ensp
ENSP00000637353
resolver
enst
ENST00000269095
resolver
enst
ENST00000377184
resolver
enst
ENST00000461854
resolver
enst
ENST00000518766
resolver
enst
ENST00000523501
resolver
enst
ENST00000536246
resolver
enst
ENST00000612133
resolver
enst
ENST00000622681
resolver
enst
ENST00000881428
resolver
enst
ENST00000881432
resolver
enst
ENST00000967293
resolver
enst
ENST00000967294
resolver
genesymbol
MPP2
resolver
genesymbol_syn
DLG2
resolver
hgnc
HGNC:7220
resolver
uniprot
A0A0A0MRU0
resolver
uniprot
A0A0A0MTF9
resolver
uniprot
A0A0C4DH75
resolver
uniprot
B4DGE9
resolver
uniprot
B4DRJ0
resolver
uniprot
B4DRL7
resolver
uniprot
B4DZ84
resolver
uniprot
B7Z3G8
resolver
uniprot
D3DX48
resolver
uniprot
D3DX49
resolver
uniprot
E7EV80
resolver
uniprot
E7EV91
resolver
uniprot
E7EX01
resolver
uniprot
Q53ES9
resolver
uniprot
Q5CZB9
resolver
uniprot
Q9BQJ2
resolver
uniprot_entry
A0A0A0MRU0_HUMAN
resolver
uniprot_entry
A0A0A0MTF9_HUMAN
resolver
uniprot_entry
A0A0C4DH75_HUMAN
resolver
uniprot_entry
B4DRL7_HUMAN
resolver
uniprot_entry
B4DZ84_HUMAN
resolver
uniprot_entry
D3DX48_HUMAN
resolver
uniprot_entry
D3DX49_HUMAN
resolver
uniprot_entry
MPP2_HUMAN
resolver
uniprot_sec
B4DGE9
resolver
uniprot_sec
B4DRJ0
resolver
uniprot_sec
B7Z3G8
resolver
uniprot_sec
E7EV80
resolver
uniprot_sec
E7EV91
resolver
uniprot_sec
E7EX01
resolver
uniprot_sec
Q53ES9
resolver
uniprot_sec
Q5CZB9
resolver
uniprot_sec
Q9BQJ2
resolver
amino_acid_sequence
MPVAATNSETAMQQVLDNLGSLPSATGAAELDLIFLRGIMESPIVRSLAKVIMVLWFMQQNVFVPMKYMLKYFGAHERLEETKLEAVRDNNLELVQEILRDLAHVAEQSSTAAELAHILQEPHFQSLLETHDSVASKTYETPPPSPGLDPTFSNQPVPPDAVRMVGIRKTAGEHLGVTFRVEGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPVGSDPRALQELLRNASGSVILKILPSYQEPHLPRQVFVKCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGSAGLIPSQLLEEKRKAFVKRDLELTPNSGTLCGSLSGKKKKRMMYLTTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVPVSWVY
uniprot
proteins
function
FUNCTION: Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017). {ECO:0000250|UniProtKB:D3ZAA9, ECO:0000250|UniProtKB:Q9WV34, ECO:0000269|PubMed:19665017}.
uniprot
proteins
mass_dalton
64581
uniprot
proteins
mutagenesis
MUTAGEN 363; /note="Y->A: Enhances association with the cytoskeleton. Diminishes the inhibitory effect on SRC."; /evidence="ECO:0000269|PubMed:19665017"; MUTAGEN 363; /note="Y->D: Enhances association with the cytoskeleton."; /evidence="ECO:0000269|PubMed:19665017
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by SRC. {ECO:0000269|PubMed:19665017}.
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19665017
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
7590743
uniprot
proteins
sequence_length
576
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19665017}. Membrane {ECO:0000269|PubMed:19665017}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9WV34}. Postsynaptic density {ECO:0000250|UniProtKB:Q9WV34}. Note=Prominently expressed in the postsynaptic densities of dendritic spines, is also detected in dendritic shafts. {ECO:0000250|UniProtKB:Q9WV34}.
uniprot
proteins