FCGR2B
entrez
2213
canonical
uniprot
P31994
canonical
ensembl
ENSG00000072694
resolver
ensp
ENSP00000351497
resolver
ensp
ENSP00000356938
resolver
ensp
ENSP00000551033
resolver
ensp
ENSP00000551034
resolver
ensp
ENSP00000773767
resolver
ensp
ENSP00000773770
resolver
ensp
ENSP00000773775
resolver
ensp
ENSP00000773778
resolver
ensp
ENSP00000773782
resolver
ensp
ENSP00000773783
resolver
genesymbol
FCGR2B
resolver
genesymbol_syn
CD32
resolver
genesymbol_syn
FCG2
resolver
genesymbol_syn
IGFR2
resolver
hgnc
HGNC:3618
resolver
uniprot
A6H8N3
resolver
uniprot
O95649
resolver
uniprot
Q53X85
resolver
uniprot
Q5VXA9
resolver
uniprot
Q8NIA1
resolver
uniprot_entry
FCG2B_HUMAN
resolver
uniprot_sec
A6H8N3
resolver
uniprot_sec
O95649
resolver
uniprot_sec
Q53X85
resolver
uniprot_sec
Q5VXA9
resolver
uniprot_sec
Q8NIA1
resolver
amino_acid_sequence
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISALPGYPECREMGETLPEKPANPTNPDEADKVGAENTITYSLLMHPDALEEPDDQNRI
uniprot
proteins
disease_involvement
DISEASE: Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269|PubMed:12115230, ECO:0000269|PubMed:20385827}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
uniprot
proteins
mass_dalton
34044
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by the SRC-type Tyr-kinases LYN and BLK. {ECO:0000269|PubMed:8756631}.
uniprot
proteins
pubmed
10064577
uniprot
proteins
pubmed
12115230
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15914856
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17435165
uniprot
proteins
pubmed
20385827
uniprot
proteins
pubmed
2142460
uniprot
proteins
pubmed
2529342
uniprot
proteins
pubmed
2531080
uniprot
proteins
pubmed
28566370
uniprot
proteins
pubmed
37421619
uniprot
proteins
pubmed
8327512
uniprot
proteins
pubmed
8466861
uniprot
proteins
pubmed
8756631
uniprot
proteins
pubmed
9232445
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 218..240; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins