MTHFD2
entrez
10797
canonical
uniprot
P13995
canonical
ensembl
ENSG00000065911
resolver
ensp
ENSP00000377617
resolver
ensp
ENSP00000503701
resolver
ensp
ENSP00000504392
resolver
genesymbol
MTHFD2
resolver
genesymbol_syn
NMDMC
resolver
hgnc
HGNC:7434
resolver
uniprot
Q53G90
resolver
uniprot
Q53GV5
resolver
uniprot
Q53S36
resolver
uniprot
Q7Z650
resolver
uniprot_entry
MTDC_HUMAN
resolver
uniprot_sec
Q53G90
resolver
uniprot_sec
Q53GV5
resolver
uniprot_sec
Q53S36
resolver
uniprot_sec
Q7Z650
resolver
amino_acid_sequence
MAATSLMSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN
uniprot
proteins
ec_number
1.5.1.15
uniprot
proteins
ec_number
3.5.4.9
uniprot
proteins
function
FUNCTION: Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. {ECO:0000269|PubMed:16100107}.
uniprot
proteins
mass_dalton
37895
uniprot
proteins
mutagenesis
MUTAGEN 168; /note="D->A: Significant loss of NAD and NADP-dependent dehydrogenase specific activity."; /evidence="ECO:0000269|PubMed:16100107"; MUTAGEN 168; /note="D->E: Complete loss of NAD and NADP-dependent dehydrogenase specific activity."; /evidence="ECO:0000269|PubMed:16100107"; MUTAGEN 168; /note="D->N: 80% decrease in NAD-dependent dehydrogenase specific activity. 18% decrease in NADP-dependent dehydrogenase specific activity. Reduced affinity for magnesium."; /evidence="ECO:0000269|PubMed:16100107"; MUTAGEN 168; /note="D->S: 82% decrease in NAD-dependent dehydrogenase specific activity. 65% decrease in NADP-dependent dehydrogenase specific activity. Reduced affinity for magnesium."; /evidence="ECO:0000269|PubMed:16100107"; MUTAGEN 201; /note="R->A,S,K: Complete loss of NAD and NADP-dependent dehydrogenase specific activity."; /evidence="ECO:0000269|PubMed:16100107"; MUTAGEN 225; /note="D->A,S,E: Complete loss of NAD and NADP-dependent dehydrogenase specific activity."; /evidence="ECO:0000269|PubMed:16100107"; MUTAGEN 225; /note="D->N: 84% decrease in NAD-dependent dehydrogenase specific activity. 36% increase in NADP-dependent dehydrogenase specific activity. Reduced affinity for magnesium."; /evidence="ECO:0000269|PubMed:16100107"; MUTAGEN 233; /note="R->A: Significant loss of NAD and NADP-dependent dehydrogenase specific activity."; /evidence="ECO:0000269|PubMed:16100107"; MUTAGEN 233; /note="R->K: 50% decrease in NAD and NADP-dependent dehydrogenase specific activity. Reduced affinity for magnesium."; /evidence="ECO:0000269|PubMed:16100107"; MUTAGEN 233; /note="R->S: Almost complete loss of NAD-dependent dehydrogenase specific activity. 50% decrease in NADP-dependent dehydrogenase specific activity."; /evidence="ECO:0000269|PubMed:16100107
uniprot
proteins
protein_family
Tetrahydrofolate dehydrogenase/cyclohydrolase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16100107
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
2587219
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27899380
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
8218174
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion.
uniprot
proteins