RAB40AL
entrez
282808
canonical
uniprot
P0C0E4
canonical
ensembl
ENSG00000102128
resolver
ensp
ENSP00000218249
resolver
enst
ENST00000218249
resolver
genesymbol
RAB40AL
resolver
genesymbol_syn
RLGP
resolver
hgnc
HGNC:25410
resolver
uniprot
Q495H3
resolver
uniprot_entry
RB40L_HUMAN
resolver
uniprot_sec
Q495H3
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:P62820}.
uniprot
proteins
amino_acid_sequence
MSAPGSPDQAYDFLLKFLLVGDRDVGKSEILESLQDGTAESPYSHLGGIDYKTTTILLDGQRVKLKLWDTSGQGRFCTIFRSYSRGAQGVILVYDIANRWSFEGMDRWIKKIEEHAPGVPKILVGNRLHLAFKRQVPREQAQAYAERLGVTFFEVSPLCNFNIIESFTELARIVLLRHRLNWLGRPSKVLSLQDLCCRTIVSCTPVHLVDKLPLPIALRSHLKSFSMAKGLNARMMRGLSYSLTTSSTHKRSSLCKVKIVCPPQSPPKNCTRNSCKIS
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: May act as substrate-recognition component of the ECS(RAB40) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). {ECO:0000250|UniProtKB:Q8WXH6, ECO:0000250|UniProtKB:Q96S21}.
uniprot
proteins
mass_dalton
31239
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
12145744
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
22581972
uniprot
proteins
pubmed
25044830
uniprot
proteins
pubmed
25370018
uniprot
proteins
pubmed
26300074
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:22581972}. Mitochondrion {ECO:0000269|PubMed:12145744, ECO:0000269|PubMed:22581972}.
uniprot
proteins