Chmp5
entrez
76959
canonical
uniprot
Q9D7S9
canonical
ensembl
ENSMUSG00000028419
resolver
ensp
ENSMUSP00000030128
resolver
enst
ENSMUST00000030128
resolver
genesymbol
Chmp5
resolver
genesymbol_syn
Snf7dc2
resolver
uniprot
Q3UI64
resolver
uniprot_entry
CHMP5_MOUSE
resolver
uniprot_sec
Q3UI64
resolver
amino_acid_sequence
MNRFFGKAKPKAPPPSLTDCIGTVDSRAESIDKKISRLDAELVKYKDQIKKMREGPAKNMVKQKALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKTTVDAMKLGVKEMKKAYKEVKIDQIEDLQDQLEDMMEDANEIQEALGRSYGTPELDEDDLEAELDALGDELLADEDSSYLDEAASAPAIPEGVPTDTKNKDGVLVDEFGLPQIPAS
uniprot
proteins
function
FUNCTION: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
24576
uniprot
proteins
post_translational_modification
PTM: ISGylated. Isgylation inhibits its interaction with VTA1 (By similarity). {ECO:0000250|UniProtKB:Q9NZZ3}.
uniprot
proteins
protein_family
SNF7 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9NZZ3}. Endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Midbody {ECO:0000250|UniProtKB:Q9NZZ3}. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Flemming body. {ECO:0000250|UniProtKB:Q9NZZ3}.
uniprot
proteins