Gnmt
entrez
14711
canonical
uniprot
Q9QXF8
canonical
ensembl
ENSMUSG00000002769
resolver
ensp
ENSMUSP00000002846
resolver
ensp
ENSMUSP00000189895
resolver
ensp
ENSMUSP00000189899
resolver
enst
ENSMUST00000002846
resolver
genesymbol
Gnmt
resolver
uniprot
Q91WN7
resolver
uniprot_entry
GNMT_MOUSE
resolver
uniprot_sec
Q91WN7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 5-methyltetrahydrofolate monoglutamate and by 5-methyltetrahydrofolate pentaglutamate, inhibition is much more effective by the pentaglutamate form than by the monoglutamate form. Two molecules of 5-methyltetrahydrofolate are bound per tetramer. The binding sites are localized between subunits. Inhibitor binding may preclude movements of the polypeptide chain that are necessary for enzyme activity. {ECO:0000250|UniProtKB:P13255}.
uniprot
proteins
amino_acid_sequence
MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCHRVLDVACGTGVDSIMLVEEGFSVMSVDASDKMLKYALKERWNRRKEPSFDNWVIEEANWLTLDKDVLSGDGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRPGGLLVIDHRNYDYILSTGCAPPGKNIYYKSDLTKDITTSVLTVNNKAHMVTLDYTVQVPGTGRDGSPGFSKFRLSYYPHCLASFTELVRAAFGGRCQHSVLGDFKPYKPGQAYVPCYFIHVLKKTD
uniprot
proteins
ec_number
2.1.1.20
uniprot
proteins
function
FUNCTION: Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate (PubMed:15340920). Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine (PubMed:16779654). {ECO:0000269|PubMed:15340920, ECO:0000269|PubMed:16779654}.
uniprot
proteins
mass_dalton
32675
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Glycine N-methyltransferase family
uniprot
proteins
pubmed
15340920
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16779654
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
9497905
uniprot
proteins
sequence_length
293
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P13255}.
uniprot
proteins