JADE2
entrez
23338
canonical
uniprot
Q9NQC1
canonical
ensembl
ENSG00000043143
resolver
ensp
ENSP00000282605
resolver
ensp
ENSP00000354425
resolver
ensp
ENSP00000378451
resolver
ensp
ENSP00000422991
resolver
ensp
ENSP00000483173
resolver
ensp
ENSP00000505514
resolver
ensp
ENSP00000562521
resolver
ensp
ENSP00000562522
resolver
ensp
ENSP00000562523
resolver
ensp
ENSP00000562524
resolver
ensp
ENSP00000562525
resolver
ensp
ENSP00000562526
resolver
ensp
ENSP00000562527
resolver
ensp
ENSP00000562528
resolver
ensp
ENSP00000562531
resolver
ensp
ENSP00000562533
resolver
ensp
ENSP00000562535
resolver
ensp
ENSP00000562537
resolver
ensp
ENSP00000562540
resolver
ensp
ENSP00000600815
resolver
ensp
ENSP00000600816
resolver
ensp
ENSP00000600819
resolver
ensp
ENSP00000600820
resolver
ensp
ENSP00000600821
resolver
ensp
ENSP00000616775
resolver
ensp
ENSP00000616778
resolver
enst
ENST00000282605
resolver
enst
ENST00000361895
resolver
enst
ENST00000512386
resolver
enst
ENST00000612830
resolver
enst
ENST00000681547
resolver
enst
ENST00000892462
resolver
enst
ENST00000892464
resolver
enst
ENST00000892465
resolver
enst
ENST00000892466
resolver
enst
ENST00000892467
resolver
enst
ENST00000892468
resolver
enst
ENST00000892470
resolver
enst
ENST00000892471
resolver
enst
ENST00000892474
resolver
enst
ENST00000892478
resolver
enst
ENST00000892481
resolver
enst
ENST00000930756
resolver
enst
ENST00000930757
resolver
enst
ENST00000930761
resolver
enst
ENST00000930762
resolver
enst
ENST00000946716
resolver
enst
ENST00000946719
resolver
genesymbol
JADE2
resolver
genesymbol
PHF15
resolver
genesymbol_syn
KIAA0239
resolver
genesymbol_syn
PHF15
resolver
hgnc
HGNC:22984
resolver
uniprot
A0A087X085
resolver
uniprot
A0A0C4DFT8
resolver
uniprot
B3KPL2
resolver
uniprot
B4DFY8
resolver
uniprot
D3DQA3
resolver
uniprot
D6R9B8
resolver
uniprot
G3XAA4
resolver
uniprot
Q6IE80
resolver
uniprot
Q8TEK0
resolver
uniprot
Q92513
resolver
uniprot
Q96GQ6
resolver
uniprot_entry
A0A087X085_HUMAN
resolver
uniprot_entry
A0A0C4DFT8_HUMAN
resolver
uniprot_entry
B3KPL2_HUMAN
resolver
uniprot_entry
B4DFY8_HUMAN
resolver
uniprot_entry
G3XAA4_HUMAN
resolver
uniprot_entry
JADE2_HUMAN
resolver
uniprot_sec
D3DQA3
resolver
uniprot_sec
D6R9B8
resolver
uniprot_sec
Q6IE80
resolver
uniprot_sec
Q8TEK0
resolver
uniprot_sec
Q92513
resolver
uniprot_sec
Q96GQ6
resolver
amino_acid_sequence
MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSSTMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSFCQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPGSRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPLAPETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVAERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6ZQF7, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:25018020}.
uniprot
proteins
mass_dalton
87466
uniprot
proteins
mutagenesis
MUTAGEN 202; /note="C->A: Loss of E3 ubiquitin-protein ligase activity on KDM1A."; /evidence="ECO:0000269|PubMed:25018020"; MUTAGEN 243; /note="C->A: Loss of E3 ubiquitin-protein ligase activity on KDM1A."; /evidence="ECO:0000269|PubMed:25018020
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305|PubMed:25018020}.
uniprot
proteins
protein_family
JADE family
uniprot
proteins
pubmed
12693554
uniprot
proteins
pubmed
14612400
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16387653
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25018020
uniprot
proteins
pubmed
9039502
uniprot
proteins
sequence_length
790
uniprot
proteins