P0C0L6
uniprot
P0C0L6
canonical
amino_acid_sequence
MPANLTEGSFHANQTVPMLDSSPVACTEIVTFTEALEAEEWGSFYSSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKRKSRMTFFVTQLAITDSFTGLINILTDIIWRFTGDFMAPDLVCRIVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGAEKQAKVLIGIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISVIYGLVIRTIWIKSKAHETVISNCSDGELCCSYNRGLISKAKIKAIKYSIVIILAFICCWSPYFLFDMLDNFNLLPDTKERFYASVIIQNLPALNSAINPLIYCIFSGSLCSPCKVQRSQDSRMTYRERSERHEMQILSKPEFI
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for neuropeptide S (NPS). Receptor activation by NPS initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway, resulting in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels. In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction. Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade. Inhibits cell growth in response to NPS binding. {ECO:0000250|UniProtKB:Q6W5P4}.
uniprot
proteins
mass_dalton
42638
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Vasopressin/oxytocin receptor subfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6W5P4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6W5P4}.
uniprot
proteins
transmembrane_region
TRANSMEM 53..73; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 83..103; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 123..143; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 166..186; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 314..334; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins