Ppp1cb
entrez
19046
canonical
uniprot
P62141
canonical
ensembl
ENSMUSG00000014956
resolver
ensp
ENSMUSP00000015100
resolver
ensp
ENSMUSP00000144047
resolver
ensp
ENSMUSP00000242909
resolver
enst
ENSMUST00000015100
resolver
enst
ENSMUST00000201360
resolver
genesymbol
Ppp1cb
resolver
uniprot
P37140
resolver
uniprot
Q3TBE5
resolver
uniprot
Q3TL90
resolver
uniprot
Q542E7
resolver
uniprot
Q8C285
resolver
uniprot
Q9DBY2
resolver
uniprot_entry
PP1B_MOUSE
resolver
uniprot_sec
P37140
resolver
uniprot_sec
Q3TBE5
resolver
uniprot_sec
Q3TL90
resolver
uniprot_sec
Q542E7
resolver
uniprot_sec
Q8C285
resolver
uniprot_sec
Q9DBY2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg. The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAKYQYGGLNSGRPVTPPRTANPPKKR
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.53
uniprot
proteins
function
FUNCTION: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity). {ECO:0000250|UniProtKB:P62140, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:21930935}.
uniprot
proteins
mass_dalton
37187
uniprot
proteins
protein_family
PP-1 subfamily
uniprot
proteins
protein_family
PPP phosphatase family
uniprot
proteins
pubmed
14638860
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16835242
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21712997
uniprot
proteins
pubmed
21930935
uniprot
proteins
pubmed
2544298
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62140}. Nucleus {ECO:0000250|UniProtKB:P62140}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P62140}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62140}. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. {ECO:0000250|UniProtKB:P62140}.
uniprot
proteins