COL4A3
entrez
1285
canonical
uniprot
Q01955
canonical
ensembl
ENSG00000169031
resolver
ensp
ENSP00000379823
resolver
genesymbol
COL4A3
resolver
hgnc
HGNC:2204
resolver
uniprot
Q53QQ1
resolver
uniprot
Q53R14
resolver
uniprot
Q53RW8
resolver
uniprot
Q9BQT2
resolver
uniprot
Q9NYC4
resolver
uniprot
Q9UDJ9
resolver
uniprot
Q9UDK9
resolver
uniprot
Q9UDL0
resolver
uniprot
Q9UDL1
resolver
uniprot_entry
CO4A3_HUMAN
resolver
uniprot_sec
Q53QQ1
resolver
uniprot_sec
Q53R14
resolver
uniprot_sec
Q53RW8
resolver
uniprot_sec
Q9BQT2
resolver
uniprot_sec
Q9NYC4
resolver
uniprot_sec
Q9UDJ9
resolver
uniprot_sec
Q9UDK9
resolver
uniprot_sec
Q9UDL0
resolver
uniprot_sec
Q9UDL1
resolver
amino_acid_sequence
MSARTAPRPQVLLLPLLLVLLAAAPAASKGCVCKDKGQCFCDGAKGEKGEKGFPGPPGSPGQKGFTGPEGLPGPQGPKGFPGLPGLTGSKGVRGISGLPGFSGSPGLPGTPGNTGPYGLVGVPGCSGSKGEQGFPGLPGTLGYPGIPGAAGLKGQKGAPAKEEDIELDAKGDPGLPGAPGPQGLPGPPGFPGPVGPPGPPGFFGFPGAMGPRGPKGHMGERVIGHKGERGVKGLTGPPGPPGTVIVTLTGPDNRTDLKGEKGDKGAMGEPGPPGPSGLPGESYGSEKGAPGDPGLQGKPGKDGVPGFPGSEGVKGNRGFPGLMGEDGIKGQKGDIGPPGFRGPTEYYDTYQEKGDEGTPGPPGPRGARGPQGPSGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGPPGPPGDIVFRKGPPGDHGLPGYLGSPGIPGVDGPKGEPGLLCTQCPYIPGPPGLPGLPGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPGFPGFPGAQGDPGLKGEKGETLQPEGQVGVPGDPGLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGSPGSPGPAGPAGPPGYGPQGEPGLQGTQGVPGAPGPPGEAGPRGELSVSTPVPGPPGPPGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGFPGPPGPKGDQGFPGTKGSLGCPGKMGEPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSGEHGEIGLPGLPGLPGTPGNEGLDGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGDPGIPGLDRSGFPGETGSPGIPGHQGEMGPLGQRGYPGNPGILGPPGEDGVIGMMGFPGAIGPPGPPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGNPGPSEISHVIGDKGEPGLKGFAGNPGEKGNRGVPGMPGLKGLKGLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNMGMPGSKGKRGTLGFPGRAGRPGLPGIHGLQGDKGEPGYSEGTRPGPPGPTGDPGLPGDMGKKGEMGQPGPPGHLGPAGPEGAPGSPGSPGLPGKPGPHGDLGFKGIKGLLGPPGIRGPPGLPGFPGSPGPMGIRGDQGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPTGIEGFPGPPGLPGAIIPGQTGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGPPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVRGDPGTLKIISLPGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDGKPGTPGPAGEKGNKGSKGEPGPAGSDGLPGLKGKRGDSGSPATWTTRGFVFTRHSQTTAIPSCPEGTVPLYSGFSFLFVQGNQRAHGQDLGTLGSCLQRFTTMPFLFCNVNDVCNFASRNDYSYWLSTPALMPMNMAPITGRALEPYISRCTVCEGPAIAIAVHSQTTDIPPCPHGWISLWKGFSFIMFTSAGSEGTGQALASPGSCLEEFRASPFLECHGRGTCNYYSNSYSFWLASLNPERMFRKPIPSTVKAGELEKIISRCQVCMKKRH
uniprot
proteins
disease_involvement
DISEASE: Note=Autoantibodies against the NC1 domain of alpha 3(IV) are found in Goodpasture syndrome, an autoimmune disease of lung and kidney.; DISEASE: Hematuria, benign familial, 2 (BFH2) [MIM:620320]: An autosomal dominant condition characterized by non-progressive isolated microscopic hematuria that does not result in renal failure. It is characterized pathologically by thinning of the glomerular basement membrane. {ECO:0000269|PubMed:11961012}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Alport syndrome 3A, autosomal dominant (ATS3A) [MIM:104200]: A form of Alport syndrome, a syndrome characterized by progressive glomerulonephritis, glomerular basement membrane defects, renal failure, sensorineural deafness and specific eye abnormalities (lenticonous and macular flecks). The disorder shows considerable heterogeneity in that families differ in the age of end-stage renal disease and the occurrence of deafness. {ECO:0000269|PubMed:11134255, ECO:0000269|PubMed:15954103, ECO:0000269|PubMed:23927549, ECO:0000269|PubMed:29946535, ECO:0000269|PubMed:7987396, ECO:0000269|PubMed:9195222}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Alport syndrome 3B, autosomal recessive (ATS3B) [MIM:620536]: A form of Alport syndrome, a syndrome characterized by progressive glomerulonephritis, glomerular basement membrane defects, renal failure, sensorineural deafness and specific eye abnormalities (lenticonous and macular flecks). The disorder shows considerable heterogeneity in that families differ in the age of end-stage renal disease and the occurrence of deafness. {ECO:0000269|PubMed:11134255, ECO:0000269|PubMed:15954103, ECO:0000269|PubMed:23927549, ECO:0000269|PubMed:29946535, ECO:0000269|PubMed:7987396, ECO:0000269|PubMed:9195222}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; FUNCTION: Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms.
uniprot
proteins
mass_dalton
161813
uniprot
proteins
post_translational_modification
PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.; PTM: Isoform 2 contains an additional N-linked glycosylation site.; PTM: Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.; PTM: The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues. {ECO:0000250}.; PTM: Phosphorylated. Thought to be phosphorylated by CERT, but CERT does not have kinase activity. {ECO:0000269|PubMed:10212244}.
uniprot
proteins
protein_family
Type IV collagen family
uniprot
proteins
pubmed
10212244
uniprot
proteins
pubmed
10766752
uniprot
proteins
pubmed
10837460
uniprot
proteins
pubmed
11044206
uniprot
proteins
pubmed
11134255
uniprot
proteins
pubmed
11961012
uniprot
proteins
pubmed
12193605
uniprot
proteins
pubmed
12682293
uniprot
proteins
pubmed
1400291
uniprot
proteins
pubmed
15492988
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15954103
uniprot
proteins
pubmed
1737849
uniprot
proteins
pubmed
1882840
uniprot
proteins
pubmed
23927549
uniprot
proteins
pubmed
29946535
uniprot
proteins
pubmed
7523402
uniprot
proteins
pubmed
7758473
uniprot
proteins
pubmed
7987301
uniprot
proteins
pubmed
7987396
uniprot
proteins
pubmed
8006044
uniprot
proteins
pubmed
8083201
uniprot
proteins
pubmed
8294492
uniprot
proteins
pubmed
8505332
uniprot
proteins
pubmed
9195222
uniprot
proteins
pubmed
9537506
uniprot
proteins
sequence_length
1670
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). {ECO:0000250}.
uniprot
proteins