Dvl1
entrez
83721
canonical
uniprot
Q9WVB9
canonical
ensembl
ENSRNOG00000019423
resolver
ensembl
ENSRNOG00055013741
resolver
ensembl
ENSRNOG00060004547
resolver
ensembl
ENSRNOG00065010223
resolver
ensp
ENSRNOP00000026439
resolver
ensp
ENSRNOP00055019229
resolver
ensp
ENSRNOP00060005705
resolver
ensp
ENSRNOP00065012521
resolver
enst
ENSRNOT00000026439
resolver
enst
ENSRNOT00055023623
resolver
enst
ENSRNOT00060007603
resolver
enst
ENSRNOT00065016476
resolver
genesymbol
Dvl1
resolver
uniprot
Q9QUG5
resolver
uniprot
Q9WVB8
resolver
uniprot_entry
DVL1_RAT
resolver
uniprot_sec
Q9QUG5
resolver
uniprot_sec
Q9WVB8
resolver
amino_acid_sequence
MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNRDEAARTNGHPRGDRRRELGLPPDSASTVLSSELESSSFIDSDEEDNTSRLSSSTEQSTSSRLIRKHKCRRRKQRLRQTDRASSFSSITDSTMSLNIITVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTIPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAITRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAIVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSMLKHGFLRHTVNKITFSEQCYYVFGDLCSNLASLNLNSGSSGASDQDTLAPLPHPSVPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGSAGSQQSEGSKSSGSTRSSHRTPGREERRATGAGGSGSESDHTVPSGSGSTGWWERPVSQLSRGSSPRSQASAVAPGLPPLHPLTKAYAVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM
uniprot
proteins
function
FUNCTION: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
75447
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
DSH family
uniprot
proteins
pubmed
11113207
uniprot
proteins
pubmed
11354832
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
695
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes at the cell membrane upon interaction with frizzled family members. {ECO:0000250}.
uniprot
proteins