TAAR1
entrez
134864
canonical
uniprot
Q96RJ0
canonical
ensembl
ENSG00000146399
resolver
ensp
ENSP00000275216
resolver
enst
ENST00000275216
resolver
genesymbol
TAAR1
resolver
genesymbol_syn
TA1
resolver
genesymbol_syn
TAR1
resolver
genesymbol_syn
TRAR1
resolver
hgnc
HGNC:17734
resolver
uniprot
Q2M1W5
resolver
uniprot
Q3MIH8
resolver
uniprot
Q5VUQ1
resolver
uniprot_entry
TAAR1_HUMAN
resolver
uniprot_sec
Q2M1W5
resolver
uniprot_sec
Q3MIH8
resolver
uniprot_sec
Q5VUQ1
resolver
activity_regulation
ACTIVITY REGULATION: Activated by SEP-363856 small molecule: IHCH-7179 acts both as an agonist activator for HTR1A and TAAR1. {ECO:0000269|PubMed:36100653, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377}.
uniprot
proteins
amino_acid_sequence
MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
uniprot
proteins
function
FUNCTION: Intracellular G protein-coupled receptor for trace amines, which recognizes endogenous amine-containing metabolites such as beta-phenylethylamine (beta-PEA), 3-iodothyronamine (T1AM), isoamylamine (IAA), cadaverine (CAD), cyclohexylamine (CHA), p-tyramine (p-TYR), trimethylamine (TMA), octopamine and tryptamine (PubMed:11459929, PubMed:11723224, PubMed:15718104, PubMed:31399635, PubMed:36100653, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118). Also functions as a receptor for various drugs and psychoactive substances, such as amphetamine and methamphetamine (PubMed:31399635, PubMed:37935376, PubMed:37935377). Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin (PubMed:11459929, PubMed:11723224). Expressed in both the central and peripheral nervous system: TAAR1 activation regulates the activity of several neurotransmitter signaling pathways by (1) decreasing the basal firing rates of the neurons involved and by (2) lowering the sensitivity of receptors to neurotransmitters (PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:31399635, PubMed:37935376, PubMed:37963465). TAAR1 is coupled with different G(i)/G(o)-, G(s)- or G(q)/G(11) classes of G alpha proteins depending on the ligand (PubMed:31399635, PubMed:37935376, PubMed:37963465). CAD-binding is coupled to G(i)/G(o) G alpha proteins and mediates inhibition of adenylate cyclase activity (PubMed:37935376, PubMed:37963465). T1AM- or beta-PEA-binding is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:37935376, PubMed:37963465). CHA- or IAA-binding is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers (PubMed:37935376, PubMed:37963465). TMA-binding is coupled with all three G(i)/G(o)-, G(s)- or G(q)/G(11) G alpha protein subtypes (PubMed:37935376, PubMed:37963465). Amphetamine-binding is coupled with G(s)- or G(12)/G(13) G alpha protein subtypes (PubMed:31399635). {ECO:0000269|PubMed:11459929, ECO:0000269|PubMed:11723224, ECO:0000269|PubMed:15718104, ECO:0000269|PubMed:31399635, ECO:0000269|PubMed:36100653, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:38168118}.
uniprot
proteins
mass_dalton
39092
uniprot
proteins
mutagenesis
MUTAGEN 55; /note="H->A: Reduced activation of G(s) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 83; /note="R->A: Reduced activation of G(i) G alpha proteins in response to agonist-binding. Does not affect activation of G(s) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 83; /note="R->H: Abolished activation of G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:38168118"; MUTAGEN 88; /note="C->S: Slightly affects G protein-coupled receptor activity."; /evidence="ECO:0000269|PubMed:38168118"; MUTAGEN 96; /note="C->S: Abolished G protein-coupled receptor activity."; /evidence="ECO:0000269|PubMed:38168118"; MUTAGEN 103; /note="D->A,N: Abolished activation of G(s) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:38168118"; MUTAGEN 104; /note="I->A: Reduced activation of G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935377"; MUTAGEN 107; /note="S->A: Abolished activation of G(s) G alpha proteins in response to agonist-binding. Does not affect activation of G(i) or G(q) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:38168118"; MUTAGEN 114; /note="L->A: Reduced activation of G(i) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 154; /note="F->A: Abolished activation of G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 178; /note="C->S: Slightly affects G protein-coupled receptor activity."; /evidence="ECO:0000269|PubMed:38168118"; MUTAGEN 183; /note="S->A: Reduced activation of G(i) G alpha proteins in response to agonist-binding. Does not affect activation of G(s) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 184; /note="V->A: Abolished activation of G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 184; /note="V->P: Decreased G protein-coupled receptor activity in response to p-tyramine-binding."; /evidence="ECO:0000269|PubMed:38168118"; MUTAGEN 185; /note="F->A: Abolished activation of G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 186; /note="F->A: Reduced activation of G(q) G alpha proteins in response to agonist-binding. Does not affect activation of G(s) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377"; MUTAGEN 194; /note="T->A: Abolished activation of G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377"; MUTAGEN 195; /note="F->T: Increased G protein-coupled receptor activity in response to p-tyramine-binding."; /evidence="ECO:0000269|PubMed:38168118"; MUTAGEN 220; /note="Q->A: Reduced activation of G(s) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 224; /note="I->A: Reduced activation of G(s) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 253; /note="L->A: Reduced activation of G(i) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 260; /note="F->A: Reduced activation of G(s) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 264; /note="W->A: Abolished activation of G alpha proteins in response to 3-iodothyronamine-binding."; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377"; MUTAGEN 264; /note="W->F: Abolished activation of G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:38168118"; MUTAGEN 267; /note="F->A: Abolished activation of G alpha proteins in response to 3-iodothyronamine-binding. Reduced activation of G(q) G alpha proteins in response to agonist-binding. Does not affect activation of G(s) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377"; MUTAGEN 268; /note="F->A: Abolished activation of G alpha proteins in response to 3-iodothyronamine-binding."; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377"; MUTAGEN 271; /note="T->A,N: Decreased G protein-coupled receptor activity in response to p-tyramine-binding."; /evidence="ECO:0000269|PubMed:38168118"; MUTAGEN 290; /note="I->A: Reduced activation of G(i) G alpha proteins in response to agonist-binding. Does not affect activation of G(s) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 290; /note="I->N: Increased G protein-coupled receptor activity in response to Ro5256390 agonist-binding. Decreased G protein-coupled receptor activity in response to p-tyramine-binding."; /evidence="ECO:0000269|PubMed:38168118"; MUTAGEN 292; /note="F->A: Abolished activation of G(s) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 294; /note="Y->A: Reduced activation of G(s) G alpha proteins in response to agonist-binding. Does not affect activation of G(i) or G(q) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377"; MUTAGEN 304; /note="Y->A: Reduced activation of G(s) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 307; /note="F->A: Reduced activation of G(i) G alpha proteins in response to agonist-binding."; /evidence="ECO:0000269|PubMed:37935376
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11459929
uniprot
proteins
pubmed
11723224
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15718104
uniprot
proteins
pubmed
31399635
uniprot
proteins
pubmed
36100653
uniprot
proteins
pubmed
37935376
uniprot
proteins
pubmed
37935377
uniprot
proteins
pubmed
37963465
uniprot
proteins
pubmed
38168118
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:11723224, ECO:0000269|PubMed:31399635, ECO:0000269|PubMed:36100653}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:36100653}; Multi-pass membrane protein {ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:38168118}. Cell membrane {ECO:0000305|PubMed:36100653}; Multi-pass membrane protein {ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:38168118}. Note=Localizes mainly intracellularly (PubMed:11723224, PubMed:31399635, PubMed:36100653). Partially colocalizes with the endoplasmic reticulum; also found at lower lever at the plasma membrane (PubMed:36100653). {ECO:0000269|PubMed:11723224, ECO:0000269|PubMed:31399635, ECO:0000269|PubMed:36100653}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..49; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465"; TRANSMEM 60..81; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465"; TRANSMEM 97..119; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465"; TRANSMEM 140..161; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465"; TRANSMEM 189..211; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465"; TRANSMEM 250..273; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465"; TRANSMEM 287..307; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465
uniprot
proteins