MADCAM1
entrez
8174
canonical
uniprot
Q13477
canonical
ensembl
ENSG00000099866
resolver
ensp
ENSP00000215637
resolver
ensp
ENSP00000304247
resolver
genesymbol
MADCAM1
resolver
hgnc
HGNC:6765
resolver
uniprot
A5PKV4
resolver
uniprot
B2RPL9
resolver
uniprot
O60222
resolver
uniprot
O75867
resolver
uniprot
Q5UGI7
resolver
uniprot_entry
MADCA_HUMAN
resolver
uniprot_sec
A5PKV4
resolver
uniprot_sec
B2RPL9
resolver
uniprot_sec
O60222
resolver
uniprot_sec
O75867
resolver
uniprot_sec
Q5UGI7
resolver
amino_acid_sequence
MDFGLALLLAGLLGLLLGQSLQVKPLQVEPPEPVVAVALGASRQLTCRLACADRGASVQWRGLDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTFQHTVQLLVYAFPDQLTVSPAALVPGDPEVACTAHKVTPVDPNALSFSLLVGGQELEGAQALGPEVQEEEEEPQGDEDVLFRVTERWRLPPLGTPVPPALYCQATMRLPGLELSHRQAIPVLHSPTSPEPPDTTSPESPDTTSPESPDTTSQEPPDTTSPEPPDKTSPEPAPQQGSTHTPRSPGSTRTRRPEISQAGPTQGEVIPTGSSKPAGDQLPAALWTSSAVLGLLLLALPTYHLWKRCRHLAEDDTHPPASLRLLPQVSAWAGLRGTGQVGISPS
uniprot
proteins
function
FUNCTION: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
uniprot
proteins
mass_dalton
40155
uniprot
proteins
post_translational_modification
PTM: The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation. {ECO:0000250}.
uniprot
proteins
pubmed
11807247
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23297416
uniprot
proteins
pubmed
8609404
uniprot
proteins
pubmed
8989586
uniprot
proteins
pubmed
9162097
uniprot
proteins
pubmed
9655832
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 318..338; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins