Sh3bp5
entrez
24056
canonical
uniprot
Q9Z131
canonical
ensembl
ENSMUSG00000021892
resolver
ensp
ENSMUSP00000089517
resolver
ensp
ENSMUSP00000098296
resolver
ensp
ENSMUSP00000261249
resolver
ensp
ENSMUSP00000261250
resolver
ensp
ENSMUSP00000261251
resolver
ensp
ENSMUSP00000261260
resolver
genesymbol
Sh3bp5
resolver
genesymbol_syn
Sab
resolver
uniprot
Q3TTD6
resolver
uniprot
Q8C903
resolver
uniprot
Q8VCZ0
resolver
uniprot_entry
3BP5_MOUSE
resolver
uniprot_sec
Q3TTD6
resolver
uniprot_sec
Q8C903
resolver
uniprot_sec
Q8VCZ0
resolver
amino_acid_sequence
MDTALKRSRSDEPAELPPPAREVEEKEEEEERMEQGLEEEEEEVDPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELAKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLALAKGEYKAALKSLERISDEIHERRRSNAMGPRGCGVGAEGSIASVENLPVSKPEPDAISVASEAFEDDNCSNLVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVARPGSLDLPSPVSLSEFGMMFPILGPRSECSGASSPECEVERGDRAEGAENKMSDKANNNRVLGSTNGGSGRSRSQSSTSLESQALETRMKQLSLQCSKGRDGIIADIKMIFIFYTFLQ
uniprot
proteins
function
FUNCTION: Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (By similarity). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000250|UniProtKB:O60239, ECO:0000269|PubMed:10339589}.
uniprot
proteins
mass_dalton
51807
uniprot
proteins
protein_family
SH3BP5 family
uniprot
proteins
pubmed
10339589
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26506309
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O60239}; Peripheral membrane protein {ECO:0000250|UniProtKB:O60239}. Mitochondrion {ECO:0000250|UniProtKB:O60239}. Note=Colocalizes with RAB11A on cytoplasmic vesicle membranes. {ECO:0000250|UniProtKB:O60239}.
uniprot
proteins