NAALADL1
entrez
10004
canonical
uniprot
Q9UQQ1
canonical
ensembl
ENSG00000168060
resolver
ensp
ENSP00000351484
resolver
genesymbol
NAALADL1
resolver
genesymbol_syn
NAALADASEL
resolver
genesymbol_syn
NAALADL
resolver
hgnc
HGNC:23536
resolver
uniprot
C9J8A1
resolver
uniprot
C9J964
resolver
uniprot
C9JL35
resolver
uniprot
C9JSN0
resolver
uniprot
O43176
resolver
uniprot_entry
NALDL_HUMAN
resolver
uniprot_sec
C9J8A1
resolver
uniprot_sec
C9J964
resolver
uniprot_sec
C9JL35
resolver
uniprot_sec
C9JSN0
resolver
uniprot_sec
O43176
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by bestatin. {ECO:0000269|PubMed:25752612}.
uniprot
proteins
amino_acid_sequence
MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIRENLRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIVGPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQGIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLPPSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNGTLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPDRYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGLIGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGDLSIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSARIYPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSFLQAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQLMLLERTFLNPRAFPEERYYSHVLWAPRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQLSIVVTALEGAAATLRPVADL
uniprot
proteins
ec_number
3.4.11.-
uniprot
proteins
function
FUNCTION: Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position (PubMed:25752612). Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity (PubMed:25752612). {ECO:0000269|PubMed:25752612}.
uniprot
proteins
mass_dalton
80558
uniprot
proteins
mutagenesis
MUTAGEN 416; /note="E->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:25752612
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:O54697}.
uniprot
proteins
protein_family
M28B subfamily
uniprot
proteins
protein_family
Peptidase M28 family
uniprot
proteins
pubmed
10085079
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
25752612
uniprot
proteins
pubmed
9388249
uniprot
proteins
sequence_length
740
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:O54697}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O54697}. Note=Ileal brush border membrane. {ECO:0000250|UniProtKB:O54697}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..28; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins