Il1b
entrez
16176
canonical
uniprot
P10749
canonical
ensembl
ENSMUSG00000027398
resolver
ensp
ENSMUSP00000028881
resolver
enst
ENSMUST00000028881
resolver
genesymbol
Il1b
resolver
uniprot
Q2M4J6
resolver
uniprot_entry
IL1B_MOUSE
resolver
uniprot_sec
Q2M4J6
resolver
amino_acid_sequence
MATVPELNCEMPPFDSDENDLFFEVDGPQKMKGCFQTFDLGCPDESIQLQISQQHINKSFRQAVSLIVAVEKLWQLPVSFPWTFQDEDMSTFFSFIFEEEPILCDSWDDDDNLLVCDVPIRQLHYRLRDEQQKSLVLSDPYELKALHLNGQNINQQVIFSMSFVQGEPSNDKIPVALGLKGKNLYLSCVMKDGTPTLQLESVDPKQYPKKKMEKRFVFNKIEVKSKVEFESAEFPNWYISTSQAEHKPVFLGNNSGQDIIDFTMESVSS
uniprot
proteins
function
FUNCTION: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. {ECO:0000250|UniProtKB:P01584}.
uniprot
proteins
mass_dalton
30931
uniprot
proteins
post_translational_modification
PTM: Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated. {ECO:0000250|UniProtKB:P01584}.
uniprot
proteins
protein_family
IL-1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16407890
uniprot
proteins
pubmed
17284521
uniprot
proteins
pubmed
17641058
uniprot
proteins
pubmed
1807351
uniprot
proteins
pubmed
2967326
uniprot
proteins
pubmed
3491144
uniprot
proteins
pubmed
3492706
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17284521}. Secreted {ECO:0000269|PubMed:17284521, ECO:0000269|PubMed:17641058}. Lysosome {ECO:0000250|UniProtKB:P01584}. Secreted, extracellular exosome {ECO:0000269|PubMed:17641058}. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10. {ECO:0000250|UniProtKB:P01584}.
uniprot
proteins