EIF3J
entrez
8669
canonical
uniprot
O75822
canonical
ensembl
ENSG00000104131
resolver
ensp
ENSP00000261868
resolver
ensp
ENSP00000414548
resolver
ensp
ENSP00000440221
resolver
genesymbol
EIF3J
resolver
genesymbol_syn
EIF3S1
resolver
hgnc
HGNC:3270
resolver
uniprot
B4DUI3
resolver
uniprot
F5H425
resolver
uniprot
Q9BUD2
resolver
uniprot
Q9H8Q2
resolver
uniprot
Q9UI65
resolver
uniprot_entry
EIF3J_HUMAN
resolver
uniprot_sec
B4DUI3
resolver
uniprot_sec
F5H425
resolver
uniprot_sec
Q9BUD2
resolver
uniprot_sec
Q9H8Q2
resolver
uniprot_sec
Q9UI65
resolver
amino_acid_sequence
MAAAAAAAGDSDSWDADAFSVEDPVRKVGGGGTAGGDRWEGEDEDEDVKDNWDDDDDEKKEEAEVKPEVKISEKKKIAEKIKEKERQQKKRQEEIKKRLEEPEEPKVLTPEEQLADKLRLKKLQEESDLELAKETFGVNNAVYGIDAMNPSSRDDFTEFGKLLKDKITQYEKSLYYASFLEVLVRDVCISLEIDDLKKITNSLTVLCSEKQKQEKQSKAKKKKKGVVPGGGLKATMKDDLADYGGYDGGYVQDYEDFM
uniprot
proteins
function
FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.
uniprot
proteins
mass_dalton
29062
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation is enhanced upon serum stimulation. {ECO:0000255|HAMAP-Rule:MF_03009, ECO:0000269|PubMed:17322308}.
uniprot
proteins
protein_family
EIF-3 subunit J family
uniprot
proteins
pubmed
14519125
uniprot
proteins
pubmed
14688252
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15703437
uniprot
proteins
pubmed
16322461
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
16766523
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17190833
uniprot
proteins
pubmed
17322308
uniprot
proteins
pubmed
17588516
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18599441
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25849773
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27462815
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
9822659
uniprot
proteins
sequence_length
258
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03009}.
uniprot
proteins