PTPRH
entrez
5794
canonical
uniprot
Q9HD43
canonical
ensembl
ENSG00000080031
resolver
ensp
ENSP00000263434
resolver
ensp
ENSP00000365528
resolver
ensp
ENSP00000560374
resolver
ensp
ENSP00000560375
resolver
ensp
ENSP00000560377
resolver
ensp
ENSP00000560381
resolver
genesymbol
PTPRH
resolver
genesymbol_syn
SAP1
resolver
hgnc
HGNC:9672
resolver
uniprot
C9JCH2
resolver
uniprot
Q15426
resolver
uniprot
Q2NKN9
resolver
uniprot
Q2NKP0
resolver
uniprot_entry
PTPRH_HUMAN
resolver
uniprot_sec
C9JCH2
resolver
uniprot_sec
Q15426
resolver
uniprot_sec
Q2NKN9
resolver
uniprot_sec
Q2NKP0
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by reversible dimerization. Dimerization reduces its catalytic activity. {ECO:0000269|PubMed:15850787}.
uniprot
proteins
amino_acid_sequence
MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity). {ECO:0000250|UniProtKB:E9Q0N2, ECO:0000269|PubMed:11278335, ECO:0000269|PubMed:12101188, ECO:0000269|PubMed:12837766, ECO:0000269|PubMed:15850787}.
uniprot
proteins
mass_dalton
122353
uniprot
proteins
mutagenesis
MUTAGEN 986; /note="D->A: Loss of activity. Acts as a dominant negative mutant."; /evidence="ECO:0000269|PubMed:11278335"; MUTAGEN 1020; /note="C->S: Loss of activity. No induction of apoptosis."; /evidence="ECO:0000269|PubMed:11278335, ECO:0000269|PubMed:12101188
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 3 subfamily
uniprot
proteins
pubmed
11278335
uniprot
proteins
pubmed
11435690
uniprot
proteins
pubmed
12101188
uniprot
proteins
pubmed
12837766
uniprot
proteins
pubmed
12879010
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15850787
uniprot
proteins
pubmed
8294459
uniprot
proteins
sequence_length
1115
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, microvillus membrane {ECO:0000250|UniProtKB:E9Q0N2}; Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:E9Q0N2}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12879010}. Note=Colocalizes with CEACAM20 at the apical brush border of intestinal cells. {ECO:0000250|UniProtKB:E9Q0N2}.
uniprot
proteins
transmembrane_region
TRANSMEM 755..775; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins