GDI2
entrez
2665
canonical
uniprot
P50395
canonical
ensembl
ENSG00000057608
resolver
ensp
ENSP00000369528
resolver
ensp
ENSP00000369538
resolver
genesymbol
GDI2
resolver
genesymbol_syn
HEL-S-46e
resolver
genesymbol_syn
RABGDIB
resolver
hgnc
HGNC:4227
resolver
uniprot
O43928
resolver
uniprot
Q5SX88
resolver
uniprot
Q6IAT1
resolver
uniprot
Q9UQM6
resolver
uniprot_entry
GDIB_HUMAN
resolver
uniprot_entry
Q6IAT1_HUMAN
resolver
uniprot_sec
O43928
resolver
uniprot_sec
Q5SX88
resolver
uniprot_sec
Q9UQM6
resolver
amino_acid_sequence
MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESASITPLEDLYKRFKIPGSPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVTEGSFVYKGGKIYKVPSTEAEALASSLMGLFEKRRFRKFLVYVANFDEKDPRTFEGIDPKKTTMRDVYKKFDLGQDVIDFTGHALALYRTDDYLDQPCYETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPIEEIIVQNGKVIGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRVICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLLVPKDLGTESQIFISRTYDATTHFETTCDDIKNIYKRMTGSEFDFEEMKRKKNDIYGED
uniprot
proteins
function
FUNCTION: GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}.
uniprot
proteins
mass_dalton
50663
uniprot
proteins
protein_family
Rab GDI family
uniprot
proteins
pubmed
10996854
uniprot
proteins
pubmed
11809807
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19570034
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25860027
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26824392
uniprot
proteins
pubmed
29125462
uniprot
proteins
pubmed
7543319
uniprot
proteins
pubmed
9434952
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19570034}.
uniprot
proteins