SLC47A2
entrez
146802
canonical
uniprot
Q86VL8
canonical
ensembl
ENSG00000180638
resolver
ensp
ENSP00000326671
resolver
ensp
ENSP00000338084
resolver
ensp
ENSP00000391848
resolver
genesymbol
SLC47A2
resolver
genesymbol_syn
MATE2
resolver
hgnc
HGNC:26439
resolver
uniprot
A0JBX9
resolver
uniprot
A0P8Z7
resolver
uniprot
Q63HJ9
resolver
uniprot
Q8IV44
resolver
uniprot
Q96NA1
resolver
uniprot_entry
S47A2_HUMAN
resolver
uniprot_sec
A0JBX9
resolver
uniprot_sec
A0P8Z7
resolver
uniprot_sec
Q63HJ9
resolver
uniprot_sec
Q8IV44
resolver
uniprot_sec
Q96NA1
resolver
amino_acid_sequence
MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWLKGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDWKLAAEEAKKHSGRQQQQRAESTATRPGPEKAVLSSVATGSSPGITLTTYSRSECHVDFFRTPEEAHALSAPTSRLSVKQLVIRRGAALGAASATLMVGLTVRILATRH
uniprot
proteins
function
FUNCTION: Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney. {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:16914559, ECO:0000269|PubMed:17509534, ECO:0000269|PubMed:19158817, ECO:0000269|PubMed:21419862}.; FUNCTION: [Isoform 6]: Non-functional protein. {ECO:0000269|PubMed:16807400}.
uniprot
proteins
mass_dalton
65085
uniprot
proteins
protein_family
Multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16807400
uniprot
proteins
pubmed
16914559
uniprot
proteins
pubmed
17509534
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19158817
uniprot
proteins
pubmed
21419862
uniprot
proteins
sequence_length
602
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19158817}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:21419862}; Multi-pass membrane protein {ECO:0000255}. Note=Detected in the renal urinary tubules. {ECO:0000269|PubMed:21419862}.; SUBCELLULAR LOCATION: [Isoform 6]: Apical cell membrane {ECO:0000269|PubMed:16807400}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of the proximal tubules. {ECO:0000269|PubMed:16807400}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 67..87; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 154..174; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 220..240; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 249..269; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 290..309; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 328..348; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 369..389; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 403..423; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 443..463; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 467..487; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 579..599; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins