TLE3
entrez
7090
canonical
uniprot
Q04726
canonical
ensembl
ENSG00000140332
resolver
ensp
ENSP00000319233
resolver
ensp
ENSP00000394717
resolver
ensp
ENSP00000415057
resolver
ensp
ENSP00000452871
resolver
ensp
ENSP00000453081
resolver
ensp
ENSP00000453083
resolver
ensp
ENSP00000453373
resolver
ensp
ENSP00000453435
resolver
ensp
ENSP00000453760
resolver
ensp
ENSP00000588415
resolver
ensp
ENSP00000622267
resolver
ensp
ENSP00000689785
resolver
ensp
ENSP00000689786
resolver
ensp
ENSP00000689787
resolver
enst
ENST00000559929
resolver
genesymbol
TLE3
resolver
genesymbol_syn
KIAA1547
resolver
hgnc
HGNC:11839
resolver
uniprot
B3KUA2
resolver
uniprot
B4DPT0
resolver
uniprot
E9PD64
resolver
uniprot
F8W964
resolver
uniprot
H0YL70
resolver
uniprot
Q6PI57
resolver
uniprot
Q6PRX3
resolver
uniprot
Q8IVV6
resolver
uniprot
Q8WVR2
resolver
uniprot
Q9HCM5
resolver
uniprot_entry
B3KUA2_HUMAN
resolver
uniprot_entry
H0YL70_HUMAN
resolver
uniprot_entry
Q6PRX3_HUMAN
resolver
uniprot_entry
TLE3_HUMAN
resolver
uniprot_sec
B4DPT0
resolver
uniprot_sec
E9PD64
resolver
uniprot_sec
F8W964
resolver
uniprot_sec
Q6PI57
resolver
uniprot_sec
Q8IVV6
resolver
uniprot_sec
Q8WVR2
resolver
uniprot_sec
Q9HCM5
resolver
amino_acid_sequence
MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTVKDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKPPGMDPIGIMASALRTPISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY
uniprot
proteins
function
FUNCTION: Transcriptional coregulator that binds to a number of transcription factors. Acts as a regulator of adipogenesis both by acting as a corepressor of Wnt signaling and coactivator for PPARG (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). Promotes diffentiation of white adipocytes by acting as a coactivator for PPARG and preventing the association between PRDM16 and PPARG, thereby preventing browning of white adipocytes (By similarity). {ECO:0000250|UniProtKB:Q08122, ECO:0000269|PubMed:28689657}.
uniprot
proteins
mass_dalton
83417
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by XIAP/BIRC4 (PubMed:22304967). This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4 (PubMed:22304967). Ubiquitinated at Lys-720 by UBR5 in response to Wnt signaling, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome (PubMed:28689657). {ECO:0000269|PubMed:22304967, ECO:0000269|PubMed:28689657}.
uniprot
proteins
protein_family
WD repeat Groucho/TLE family
uniprot
proteins
pubmed
10748198
uniprot
proteins
pubmed
10997877
uniprot
proteins
pubmed
1303260
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18254933
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22304967
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26235987
uniprot
proteins
pubmed
28689657
uniprot
proteins
sequence_length
772
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1303260, ECO:0000269|PubMed:22304967}. Chromosome {ECO:0000250|UniProtKB:Q08122}. Note=Localizes to chromatin. {ECO:0000250|UniProtKB:Q08122}.
uniprot
proteins