GPX8
entrez
493869
canonical
uniprot
Q8TED1
canonical
ensembl
ENSG00000164294
resolver
ensp
ENSP00000296734
resolver
ensp
ENSP00000423822
resolver
ensp
ENSP00000427466
resolver
enst
ENST00000296734
resolver
enst
ENST00000503787
resolver
enst
ENST00000515370
resolver
genesymbol
GPX8
resolver
hgnc
HGNC:33100
resolver
uniprot
B4DPY0
resolver
uniprot
E7ETY7
resolver
uniprot
J3KNB5
resolver
uniprot_entry
B4DPY0_HUMAN
resolver
uniprot_entry
E7ETY7_HUMAN
resolver
uniprot_entry
GPX8_HUMAN
resolver
uniprot_entry
J3KNB5_HUMAN
resolver
amino_acid_sequence
MEPLAAYPLKCSGPRAKVFAVLLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTVSLEKYKGKVSLVVNVASDCQLTDRNYLGLKELHKEFGPSHFSVLAFPCNQFGESEPRPSKEVESFARKNYGVTFPIFHKIKILGSEGEPAFRFLVDSSKKEPRWNFWKYLVNPEGQVVKFWKPEEPIEVIRPDIAALVRQVIIKKKEDL
uniprot
proteins
ec_number
5.3.4.1
uniprot
proteins
function
FUNCTION: Acts as an endoplasmic reticulum (ER) thiol peroxidase that maintains ER redox homeostasis and protects the cytosol from ER-derived H(2)O(2)(PubMed:24566470, PubMed:32719007). Functions in a redox relay with ERO1A, using ERO1A-generated H(2)O(2) to drive PDI oxidation, linking peroxide detoxification to productive disulfide formation (PubMed:21215271). Modulates endoplasmic reticulum Ca(2+) levels mainly through SERCA pump activity and partially by influencing passive Ca(2+) leakage (PubMed:28129698). {ECO:0000269|PubMed:21215271, ECO:0000269|PubMed:24566470, ECO:0000269|PubMed:28129698, ECO:0000269|PubMed:32719007}.
uniprot
proteins
mass_dalton
23881
uniprot
proteins
mutagenesis
MUTAGEN 79; /note="C->S: Almost complete loss of inhibitory effect on endoplasmic reticulum Ca(2+) levels; when associated with A-108."; /evidence="ECO:0000269|PubMed:28129698"; MUTAGEN 108; /note="C->A: Almost complete loss of inhibitory effect on endoplasmic reticulum Ca(2+) levels; when associated with S-79."; /evidence="ECO:0000269|PubMed:28129698"; MUTAGEN 108; /note="C->A: Strong loss of PDI oxidation activity."; /evidence="ECO:0000269|PubMed:32719007"; MUTAGEN 114; /note="S->Q: Stronger PDI oxidation activity."; /evidence="ECO:0000269|PubMed:32719007
uniprot
proteins
protein_family
Glutathione peroxidase family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21215271
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24566470
uniprot
proteins
pubmed
28129698
uniprot
proteins
pubmed
32719007
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21215271, ECO:0000269|PubMed:24566470, ECO:0000269|PubMed:28129698}. Note=Also enriched in mitochondria-associated membranes (MAM). {ECO:0000269|PubMed:28129698}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..40; /note="Helical"; /evidence="ECO:0000269|PubMed:28129698
uniprot
proteins