Rasgrp4
entrez
170668
canonical
uniprot
Q8R5I4
canonical
ensembl
ENSRNOG00000033744
resolver
ensp
ENSRNOP00000046440
resolver
ensp
ENSRNOP00000088115
resolver
ensp
ENSRNOP00000107351
resolver
enst
ENSRNOT00000048677
resolver
enst
ENSRNOT00000127958
resolver
genesymbol
Rasgrp4
resolver
uniprot
A0ABK0LXT3
resolver
uniprot
Q8R5I3
resolver
uniprot_entry
A0ABK0LXT3_RAT
resolver
uniprot_entry
GRP4_RAT
resolver
uniprot_sec
Q8R5I3
resolver
amino_acid_sequence
MNRKDIKRKSHQECSGKAGGHGRPRQARRHKTCPTPREISKVMASLNLGVLSESSCSVDELLEECIRCFDSAGSLHRGDHILKMVLTMHSWVLPSSDLAARLLTSYQKAAKDARELRQLQICYLVRYWLTHHPEVVHQEPQLEAIINRFWTTVAQEGNMAQRSLGDASNLLSPGGPGPPPLMSSPGLGKKRKVSLLFDHLETEELAQHLTYLEFRSFQAITPQDLRGYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPAQRAQVLDKFIRVAQRLRQMQNFNTLMAVTGGLCHSAISRLKDSHVHLSPDSTKALLELTELLSSHNNYAYYRRTWASCTDFRLPVLGVHLKDLVSLYEAHPDRLPDGRLHLPKLNSLYLRLQELAALQRQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPLSPFKAPVVVEWAHGVTPKPDSATLGQHVEQLVESVFKNYDPEGHGSISLEDFEKLSANFPFACHGLHPPPRHGSGSFSREELTKYLLHASAICSKLGLAFLHAFQEVTFRKPTFCHSCNGFVSTGPLWGVTKRGYRCQDCGLCCHRHCRDQVRVECKKRPETKGDPGPPGAPGPATPLPPTGCGSEEGLSYTLSPHLESGCHLHHAWTQTESSHSSWEPEMVPCPAPVLPSKASSKSSV
uniprot
proteins
function
FUNCTION: Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP (PubMed:12493770). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting Ras-mediated activation of PIK3CG/PI3Kgamma to promote neutrophil functional responses (By similarity). In CD117(+) dendritic cells and mast cells, participates in an lipopolysaccharide (LPS)-activated signaling pathway that stimulates the production of interferon-gamma and other pro-inflammatory cytokines by natural killer (NK) cells (By similarity). May function in mast cell differentiation (PubMed:12493770). Does not appear to be required for the development of B-cells, DC-cells, T-cells, or NK-cells (By similarity). {ECO:0000250|UniProtKB:Q8BTM9, ECO:0000269|PubMed:12493770}.
uniprot
proteins
mass_dalton
75405
uniprot
proteins
protein_family
RASGRP family
uniprot
proteins
pubmed
12217396
uniprot
proteins
pubmed
12493770
uniprot
proteins
sequence_length
678
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TDF6}. Cell membrane {ECO:0000250|UniProtKB:Q8TDF6}. Note=Recruited to membranes upon activation by DAG. {ECO:0000250|UniProtKB:Q8BTM9}.
uniprot
proteins