TPMT
entrez
7172
canonical
uniprot
P51580
canonical
ensembl
ENSG00000137364
resolver
ensp
ENSP00000312304
resolver
ensp
ENSP00000534419
resolver
ensp
ENSP00000534420
resolver
ensp
ENSP00000534421
resolver
ensp
ENSP00000534422
resolver
ensp
ENSP00000534423
resolver
ensp
ENSP00000534425
resolver
ensp
ENSP00000534426
resolver
ensp
ENSP00000534427
resolver
ensp
ENSP00000534428
resolver
ensp
ENSP00000534430
resolver
ensp
ENSP00000599389
resolver
ensp
ENSP00000634049
resolver
ensp
ENSP00000634051
resolver
enst
ENST00000309983
resolver
enst
ENST00000864360
resolver
enst
ENST00000864362
resolver
enst
ENST00000864363
resolver
enst
ENST00000864364
resolver
enst
ENST00000864366
resolver
enst
ENST00000864367
resolver
enst
ENST00000864368
resolver
enst
ENST00000864369
resolver
enst
ENST00000864371
resolver
enst
ENST00000929330
resolver
enst
ENST00000963990
resolver
genesymbol
TPMT
resolver
hgnc
HGNC:12014
resolver
uniprot
O14806
resolver
uniprot
O15423
resolver
uniprot
O15424
resolver
uniprot
O15425
resolver
uniprot
O15426
resolver
uniprot
O15515
resolver
uniprot
O15548
resolver
uniprot
O43213
resolver
uniprot
Q5VUK6
resolver
uniprot
Q9UBE6
resolver
uniprot
Q9UBT8
resolver
uniprot
Q9UE62
resolver
uniprot_entry
TPMT_HUMAN
resolver
uniprot_sec
O14806
resolver
uniprot_sec
O15423
resolver
uniprot_sec
O15424
resolver
uniprot_sec
O15425
resolver
uniprot_sec
O15426
resolver
uniprot_sec
O15515
resolver
uniprot_sec
O15548
resolver
uniprot_sec
O43213
resolver
uniprot_sec
Q5VUK6
resolver
uniprot_sec
Q9UBE6
resolver
uniprot_sec
Q9UBT8
resolver
uniprot_sec
Q9UE62
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by S-adenosyl-L-homocysteine (SAH).
uniprot
proteins
amino_acid_sequence
MDGTRTSLDIEEYSDTEVQKNQVLTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTFLKGKSGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIQEFFTEQNLSYSEEPITEIPGTKVFKSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINPGDRKCYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIERLFGKICNIRCLEKVDAFEERHKSWGIDCLFEKLYLLTEK
uniprot
proteins
ec_number
2.1.1.67
uniprot
proteins
function
FUNCTION: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:18484748, PubMed:657528). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. {ECO:0000269|PubMed:18484748, ECO:0000269|PubMed:657528, ECO:0000305}.
uniprot
proteins
mass_dalton
28180
uniprot
proteins
mutagenesis
MUTAGEN 152; /note="R->E: Decreases affinity for 6-mercaptopurine. Slightly decreases catalytic activity."; /evidence="ECO:0000269|PubMed:18484748
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
TPMT family
uniprot
proteins
pubmed
10208641
uniprot
proteins
pubmed
10751626
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15819814
uniprot
proteins
pubmed
16220112
uniprot
proteins
pubmed
16476125
uniprot
proteins
pubmed
16789994
uniprot
proteins
pubmed
17243178
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18484748
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
657528
uniprot
proteins
pubmed
7628307
uniprot
proteins
pubmed
7862671
uniprot
proteins
pubmed
8316220
uniprot
proteins
pubmed
8561894
uniprot
proteins
pubmed
8644731
uniprot
proteins
pubmed
9177237
uniprot
proteins
pubmed
9246020
uniprot
proteins
pubmed
9336428
uniprot
proteins
pubmed
9453052
uniprot
proteins
pubmed
9711875
uniprot
proteins
pubmed
9931345
uniprot
proteins
pubmed
9931346
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins