SERPINA6
entrez
866
canonical
uniprot
P08185
canonical
ensembl
ENSG00000170099
resolver
ensembl
ENSG00000277405
resolver
ensp
ENSP00000342850
resolver
ensp
ENSP00000484501
resolver
ensp
ENSP00000544377
resolver
ensp
ENSP00000544378
resolver
ensp
ENSP00000544379
resolver
enst
ENST00000341584
resolver
enst
ENST00000621384
resolver
enst
ENST00000874319
resolver
enst
ENST00000874320
resolver
genesymbol
SERPINA6
resolver
genesymbol_syn
CBG
resolver
hgnc
HGNC:1540
resolver
uniprot
A0A2Z4LCH4
resolver
uniprot
A8K456
resolver
uniprot
Q7Z2Q9
resolver
uniprot_entry
A0A2Z4LCH4_HUMAN
resolver
uniprot_entry
CBG_HUMAN
resolver
uniprot_sec
A8K456
resolver
uniprot_sec
Q7Z2Q9
resolver
amino_acid_sequence
MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV
uniprot
proteins
disease_involvement
DISEASE: Corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]: Extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue. {ECO:0000269|PubMed:10634411, ECO:0000269|PubMed:1504007, ECO:0000269|PubMed:17245537, ECO:0000269|PubMed:8212073}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. {ECO:0000269|PubMed:18513745}.
uniprot
proteins
mass_dalton
45141
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; binds 5 oligosaccharide chains.; PTM: Glycosylation in position Asn-260 is needed for steroid binding.
uniprot
proteins
protein_family
Serpin family
uniprot
proteins
pubmed
10634411
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14760718
uniprot
proteins
pubmed
1504007
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
17245537
uniprot
proteins
pubmed
18513745
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
3299377
uniprot
proteins
pubmed
3347061
uniprot
proteins
pubmed
3386241
uniprot
proteins
pubmed
8212073
uniprot
proteins
sequence_length
405
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins