Crem
entrez
12916
canonical
uniprot
P27699
canonical
ensembl
ENSMUSG00000063889
resolver
ensp
ENSMUSP00000025069
resolver
ensp
ENSMUSP00000061925
resolver
ensp
ENSMUSP00000080780
resolver
ensp
ENSMUSP00000114280
resolver
ensp
ENSMUSP00000114780
resolver
ensp
ENSMUSP00000115336
resolver
ensp
ENSMUSP00000115423
resolver
ensp
ENSMUSP00000115471
resolver
ensp
ENSMUSP00000117438
resolver
ensp
ENSMUSP00000118128
resolver
ensp
ENSMUSP00000118267
resolver
ensp
ENSMUSP00000118578
resolver
ensp
ENSMUSP00000118649
resolver
ensp
ENSMUSP00000119194
resolver
ensp
ENSMUSP00000119353
resolver
ensp
ENSMUSP00000119638
resolver
ensp
ENSMUSP00000120349
resolver
ensp
ENSMUSP00000120557
resolver
ensp
ENSMUSP00000121118
resolver
ensp
ENSMUSP00000121210
resolver
ensp
ENSMUSP00000121233
resolver
ensp
ENSMUSP00000121352
resolver
ensp
ENSMUSP00000121388
resolver
ensp
ENSMUSP00000121541
resolver
ensp
ENSMUSP00000122051
resolver
ensp
ENSMUSP00000122123
resolver
ensp
ENSMUSP00000122179
resolver
ensp
ENSMUSP00000122282
resolver
ensp
ENSMUSP00000123515
resolver
ensp
ENSMUSP00000127353
resolver
ensp
ENSMUSP00000280161
resolver
ensp
ENSMUSP00000280163
resolver
ensp
ENSMUSP00000280164
resolver
enst
ENSMUST00000049942
resolver
enst
ENSMUST00000122958
resolver
enst
ENSMUST00000123672
resolver
enst
ENSMUST00000124747
resolver
enst
ENSMUST00000126578
resolver
enst
ENSMUST00000130599
resolver
enst
ENSMUST00000139537
resolver
enst
ENSMUST00000142690
resolver
enst
ENSMUST00000144496
resolver
enst
ENSMUST00000149803
resolver
enst
ENSMUST00000151084
resolver
enst
ENSMUST00000151311
resolver
enst
ENSMUST00000154705
resolver
enst
ENSMUST00000154715
resolver
enst
ENSMUST00000156234
resolver
genesymbol
Crem
resolver
genesymbol_syn
CREM
resolver
uniprot
A0A0R4J1S0
resolver
uniprot
A0A0R4J1V7
resolver
uniprot
D3YXV5
resolver
uniprot
D3Z011
resolver
uniprot
D3Z2U7
resolver
uniprot
D3Z326
resolver
uniprot
D3Z6A5
resolver
uniprot
D3Z7M6
resolver
uniprot
D3Z7P7
resolver
uniprot
E9PV35
resolver
uniprot
E9PWV9
resolver
uniprot
F6QWT6
resolver
uniprot
F6T307
resolver
uniprot
F6VJ22
resolver
uniprot
F7BP85
resolver
uniprot
P27698
resolver
uniprot
Q3TTH6
resolver
uniprot
Q5XTP8
resolver
uniprot
Q5XTP9
resolver
uniprot
Q5XTQ0
resolver
uniprot
Q5XTQ1
resolver
uniprot
Q5XTQ2
resolver
uniprot
Q5XTQ3
resolver
uniprot
Q78Z98
resolver
uniprot
Q99JF1
resolver
uniprot
Q9CQ87
resolver
uniprot
Q9D599
resolver
uniprot_entry
A0A0R4J1S0_MOUSE
resolver
uniprot_entry
A0A0R4J1V7_MOUSE
resolver
uniprot_entry
CREM_MOUSE
resolver
uniprot_entry
D3YXV5_MOUSE
resolver
uniprot_entry
D3Z011_MOUSE
resolver
uniprot_entry
D3Z2U7_MOUSE
resolver
uniprot_entry
D3Z326_MOUSE
resolver
uniprot_entry
D3Z6A5_MOUSE
resolver
uniprot_entry
D3Z7M6_MOUSE
resolver
uniprot_entry
D3Z7P7_MOUSE
resolver
uniprot_entry
E9PV35_MOUSE
resolver
uniprot_entry
E9PWV9_MOUSE
resolver
uniprot_entry
F6QWT6_MOUSE
resolver
uniprot_entry
F6T307_MOUSE
resolver
uniprot_entry
F6VJ22_MOUSE
resolver
uniprot_entry
F7BP85_MOUSE
resolver
uniprot_entry
Q3TTH6_MOUSE
resolver
uniprot_entry
Q78Z98_MOUSE
resolver
uniprot_entry
Q9CQ87_MOUSE
resolver
uniprot_entry
Q9D599_MOUSE
resolver
uniprot_sec
P27698
resolver
uniprot_sec
Q5XTP8
resolver
uniprot_sec
Q5XTP9
resolver
uniprot_sec
Q5XTQ0
resolver
uniprot_sec
Q5XTQ1
resolver
uniprot_sec
Q5XTQ2
resolver
uniprot_sec
Q5XTQ3
resolver
uniprot_sec
Q99JF1
resolver
amino_acid_sequence
MSKCGRKKYMRTNVRQMTMETVESQQDRSVTRSVAEHSSAHMQTGQISVPTLAQVSVAGSGTGRGSPAVTLVQLPSGQTVQVQGVIQTPHPSVIQSPQIQTVQVATIAETDDSADSEVIDSHKRREILSRRPSYRKILNELSSDVPGIPKIEEEKSEEEGTPPNIATMAVPTSIYQTSTGQYIAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQVVVQDEETDLAPSHMAAATGDMPTYQIRAPTTALPQGVVMAASPGSLHSPQQLAEEATRKRELRLMKNREAAKECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTD
uniprot
proteins
function
FUNCTION: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform 2, isoform 3 and isoform 4 are repressors, while isoform 1 is an activator. Plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform 1 (activator) to CRE is increased by CREB3L4. The CREM isoform 1-CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange (PubMed:16595651). {ECO:0000269|PubMed:16595651}.; FUNCTION: [Isoform 11]: Plays a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. {ECO:0000269|PubMed:16595651, ECO:0000269|PubMed:23443664}.
uniprot
proteins
mass_dalton
38516
uniprot
proteins
mutagenesis
MUTAGEN 116; /note="S->M: Loss of in vitro phosphorylation by TSSK4."; /evidence="ECO:0000269|PubMed:26940607
uniprot
proteins
post_translational_modification
PTM: Stimulated by phosphorylation (By similarity). Phosphorylated on Ser-116 by TSSK4 in vitro. {ECO:0000250|UniProtKB:Q01147, ECO:0000269|PubMed:26940607}.; PTM: Ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
10086359
uniprot
proteins
pubmed
1370576
uniprot
proteins
pubmed
16059773
uniprot
proteins
pubmed
16595651
uniprot
proteins
pubmed
1847666
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23443664
uniprot
proteins
pubmed
26940607
uniprot
proteins
pubmed
8252624
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23443664, ECO:0000269|PubMed:8252624}.; SUBCELLULAR LOCATION: [Isoform 11]: Cytoplasm. Nucleus.
uniprot
proteins