Klhl24
entrez
75785
canonical
uniprot
Q8BRG6
canonical
ensembl
ENSMUSG00000062901
resolver
ensp
ENSMUSP00000023509
resolver
ensp
ENSMUSP00000236920
resolver
enst
ENSMUST00000023509
resolver
genesymbol
Klhl24
resolver
uniprot
Q3TQG0
resolver
uniprot
Q78J30
resolver
uniprot
Q8BQU1
resolver
uniprot
Q9D5K3
resolver
uniprot_entry
KLH24_MOUSE
resolver
uniprot_sec
Q3TQG0
resolver
uniprot_sec
Q78J30
resolver
uniprot_sec
Q8BQU1
resolver
uniprot_sec
Q9D5K3
resolver
amino_acid_sequence
MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEYFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKTFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCIGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAVYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL
uniprot
proteins
function
FUNCTION: Controls KRT14 levels during keratinocytes differentiation (PubMed:27798626). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 (By similarity). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). Has a crucial role in cardiac development and function (By similarity). {ECO:0000250|UniProtKB:Q56A24, ECO:0000250|UniProtKB:Q6TFL4, ECO:0000269|PubMed:27798626}.
uniprot
proteins
mass_dalton
68364
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. Autoubiquitination leads to proteasomal degradation and is necessary to control KLHL24 levels. {ECO:0000250|UniProtKB:Q6TFL4}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
27798626
uniprot
proteins
sequence_length
600
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Perikaryon {ECO:0000250|UniProtKB:Q6TFL4}. Cell projection, axon {ECO:0000250|UniProtKB:Q56A24}. Cytoplasm {ECO:0000250|UniProtKB:Q56A24, ECO:0000250|UniProtKB:Q6TFL4}. Cell junction, desmosome {ECO:0000250|UniProtKB:Q6TFL4}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q6TFL4}.
uniprot
proteins