Fst
entrez
24373
canonical
uniprot
P21674
canonical
ensembl
ENSRNOG00000011631
resolver
ensembl
ENSRNOG00055006368
resolver
ensembl
ENSRNOG00060014325
resolver
ensembl
ENSRNOG00065020284
resolver
ensp
ENSRNOP00000015680
resolver
ensp
ENSRNOP00055008035
resolver
ensp
ENSRNOP00060019547
resolver
ensp
ENSRNOP00065027440
resolver
enst
ENSRNOT00000015680
resolver
enst
ENSRNOT00055010356
resolver
enst
ENSRNOT00060024506
resolver
enst
ENSRNOT00065034264
resolver
genesymbol
Fst
resolver
uniprot
Q80XW7
resolver
uniprot_entry
FST_RAT
resolver
uniprot_sec
Q80XW7
resolver
amino_acid_sequence
MVCARHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGRLSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGKCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPSSSEQSLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCGGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCNSISEETEEEEEEEDQDYSFPISSTLEW
uniprot
proteins
function
FUNCTION: Multifunctional regulatory protein whose primary function is to antagonize members of the transforming growth factor beta (TGF-beta) superfamily including activin, myostatin, GDF11 or bone morphogenetic proteins (BMPs). Mechanistically, binds to these ligands in the extracellular space, blocking their type II receptor-binding site to inhibit downstream signaling (By similarity). Plays an essential role in muscle fiber formation and growth both by preventing the repressive effects of myostatin and through SMAD3/AKT/mTOR signaling independently of myostatin (By similarity). Also promotes neural differentiation by antagonizing the action BMP4 (By similarity). Acts as a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) by sequestering activin A/INHBA. On the other hand, translocates into the nucleus where it down-regulates rRNA synthesis and ribosome biogenesis to maintain cellular energy homeostasis by binding to rDNA (By similarity). {ECO:0000250|UniProtKB:P19883, ECO:0000250|UniProtKB:P47931}.
uniprot
proteins
mass_dalton
37838
uniprot
proteins
pubmed
12867435
uniprot
proteins
pubmed
16482217
uniprot
proteins
pubmed
2725528
uniprot
proteins
pubmed
8472873
uniprot
proteins
sequence_length
344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P19883}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P19883}.
uniprot
proteins