Art2a
entrez
11871
canonical
uniprot
P17981
canonical
ensembl
ENSMUSG00000092517
resolver
genesymbol
Art2a
resolver
genesymbol_syn
Art2a-ps
resolver
genesymbol_syn
Rt6-1
resolver
genesymbol_syn
Rt6.1
resolver
uniprot
O35278
resolver
uniprot
Q0VB79
resolver
uniprot
Q64173
resolver
uniprot_entry
NAR2A_MOUSE
resolver
uniprot_sec
O35278
resolver
uniprot_sec
Q0VB79
resolver
uniprot_sec
Q64173
resolver
amino_acid_sequence
MPSNNFKFFLTWWLTQQVTGLAVPFMLDMAPNAFDDQYEGCVEDMEKKAPQLLQEDFNMNEELKLEWEKAEIKWKEIKNCMSYPAGFHDFHGTALVAYTGNIHRSLNEATREFKINPGNFHYKAFHYYLTRALQLLSDQGCRSVYRGTNVRFRYTGKGSVRFGHFASSSLNRSVATSSPFFNGQGTLFIIKTCLGAHIKHCSYYTHEEEVLIPGYEVFHKVKTQSVERYIQISLDSPKRKKSNFNCFYSGSTQAANVSSLGSRESCVSLFLVVLLGLLVQQLTLAEP
uniprot
proteins
disease_involvement
DISEASE: Note=A subset of Rt6+ regulatory T-cells may confer protection to autoimmune disease, and failure to develop this subset may result in enhanced susceptibility for autoimmune disease.
uniprot
proteins
ec_number
2.4.2.31
uniprot
proteins
ec_number
3.2.2.5
uniprot
proteins
function
FUNCTION: Has both ADP-ribosyltransferase activity and thiol-dependent NAD(+) glycohydrolase activity. {ECO:0000269|PubMed:11011142, ECO:0000269|PubMed:9300695}.
uniprot
proteins
mass_dalton
32801
uniprot
proteins
mutagenesis
MUTAGEN 80; /note="C->S: Loss of thiol-dependency of NADase activity."; /evidence="ECO:0000269|PubMed:11011142"; MUTAGEN 201; /note="C->F: Loss of thiol-dependency of NADase activity."; /evidence="ECO:0000269|PubMed:11011142
uniprot
proteins
post_translational_modification
PTM: It is proposed that in the absence of reducing agents, a disulfide bond is formed between Cys-80 and Cys-201, leading to a conformational change that reduces the catalytic rate of NAD glycohydrolysis.
uniprot
proteins
protein_family
Arg-specific ADP-ribosyltransferase family
uniprot
proteins
pubmed
11011142
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2362814
uniprot
proteins
pubmed
7547715
uniprot
proteins
pubmed
9300695
uniprot
proteins
sequence_length
287
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
uniprot
proteins