TLR9
entrez
54106
canonical
uniprot
Q9NR96
canonical
ensembl
ENSG00000239732
resolver
ensp
ENSP00000353874
resolver
genesymbol
TLR9
resolver
hgnc
HGNC:15633
resolver
uniprot
B3Y661
resolver
uniprot
D1CS56
resolver
uniprot
Q6UVZ2
resolver
uniprot
Q9HD68
resolver
uniprot
Q9HD69
resolver
uniprot
Q9HD70
resolver
uniprot
Q9NYC2
resolver
uniprot
Q9NYC3
resolver
uniprot_entry
TLR9_HUMAN
resolver
uniprot_sec
B3Y661
resolver
uniprot_sec
D1CS56
resolver
uniprot_sec
Q6UVZ2
resolver
uniprot_sec
Q9HD68
resolver
uniprot_sec
Q9HD69
resolver
uniprot_sec
Q9HD70
resolver
uniprot_sec
Q9NYC2
resolver
uniprot_sec
Q9NYC3
resolver
amino_acid_sequence
MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRNFCQGPTAE
uniprot
proteins
function
FUNCTION: Key component of innate and adaptive immunity (PubMed:14716310). TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms (PubMed:14716310). TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:14716310). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028, PubMed:40980882). Also acts via ADCY7, leading to cyclic di-AMP (c-di-AMP) synthesis and activation of the NLRP3 inflammasome (By similarity). Plays a role in defense against systemic mouse cytomegalovirus infection (By similarity). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366). {ECO:0000250|UniProtKB:Q9EQU3, ECO:0000269|PubMed:11564765, ECO:0000269|PubMed:14716310, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:23857366}.
uniprot
proteins
mass_dalton
115860
uniprot
proteins
mutagenesis
MUTAGEN 870; /note="Y->F: Significant inhibition of TLR9-induced IL1B, IL6, TNFAIP3, and IFNB1 levels in CpG-treated cells."; /evidence="ECO:0000269|PubMed:40980882"; MUTAGEN 980; /note="Y->F: Significant inhibition of TLR9-induced IL1B, IL6, TNFAIP3, and IFNB1 levels in CpG-treated cells."; /evidence="ECO:0000269|PubMed:40980882
uniprot
proteins
post_translational_modification
PTM: Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain. Cleavage requires UNC93B1. Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling. {ECO:0000250|UniProtKB:Q9EQU3}.; PTM: Phosphorylation of Tyr-870 by SYK and Tyr-980 by EGFR is essential for TLR9-mediated gene induction. {ECO:0000269|PubMed:40980882}.; PTM: Palmitoylated by ZDHHC3 in the Golgi regulates TLR9 trafficking from the Golgi to endosomes. Depalmitoylation by PPT1 controls the release of TLR9 from UNC93B1 in endosomes. {ECO:0000269|PubMed:38169466}.
uniprot
proteins
protein_family
Toll-like receptor family
uniprot
proteins
pubmed
11022119
uniprot
proteins
pubmed
11022120
uniprot
proteins
pubmed
11130078
uniprot
proteins
pubmed
11564765
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14716310
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17932028
uniprot
proteins
pubmed
18810425
uniprot
proteins
pubmed
19924287
uniprot
proteins
pubmed
20865800
uniprot
proteins
pubmed
23857366
uniprot
proteins
pubmed
38169466
uniprot
proteins
pubmed
40980882
uniprot
proteins
sequence_length
1032
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14716310}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9EQU3}. Early endosome membrane {ECO:0000269|PubMed:14716310}. Lysosome {ECO:0000250|UniProtKB:Q9EQU3}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q9EQU3}. Golgi apparatus membrane {ECO:0000269|PubMed:38169466}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. Exit from the ER requires UNC93B1. Endolysosomal localization is required for proteolytic cleavage and subsequent activation. Intracellular localization of the active receptor may prevent from responding to self nucleic acid. {ECO:0000250|UniProtKB:Q9EQU3, ECO:0000269|PubMed:14716310, ECO:0000269|PubMed:38169466}.
uniprot
proteins
transmembrane_region
TRANSMEM 819..839; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins