RAB6A
entrez
5870
canonical
uniprot
P20340
canonical
ensembl
ENSG00000175582
resolver
ensp
ENSP00000311449
resolver
ensp
ENSP00000336850
resolver
ensp
ENSP00000443782
resolver
ensp
ENSP00000445350
resolver
genesymbol
RAB6A
resolver
genesymbol_syn
RAB6
resolver
hgnc
HGNC:9786
resolver
uniprot
A0A024R5J5
resolver
uniprot
A8K133
resolver
uniprot
B7Z772
resolver
uniprot
F5H668
resolver
uniprot
Q1W5D8
resolver
uniprot
Q53ET8
resolver
uniprot
Q5U0A8
resolver
uniprot
Q9UBE4
resolver
uniprot_entry
A0A024R5J5_HUMAN
resolver
uniprot_entry
Q53ET8_HUMAN
resolver
uniprot_entry
RAB6A_HUMAN
resolver
uniprot_sec
A8K133
resolver
uniprot_sec
B7Z772
resolver
uniprot_sec
F5H668
resolver
uniprot_sec
Q1W5D8
resolver
uniprot_sec
Q5U0A8
resolver
uniprot_sec
Q9UBE4
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MSTGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVSEGGCSC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable). {ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:25962623, ECO:0000305|PubMed:25492866}.
uniprot
proteins
mass_dalton
23593
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="T->N: Loss of APBA1-binding. No loss of RIC1- and RGP1-binding."; /evidence="ECO:0000269|PubMed:23091056, ECO:0000269|PubMed:23737971"; MUTAGEN 46; /note="I->E: Loss of RAB6IP1-binding."; /evidence="ECO:0000269|PubMed:19141279"; MUTAGEN 72; /note="Q->L: Loss of GTPase activity. Interacts with APBA1."; /evidence="ECO:0000269|PubMed:16332443, ECO:0000269|PubMed:18243103, ECO:0000269|PubMed:19141279, ECO:0000269|PubMed:23737971
uniprot
proteins
post_translational_modification
PTM: Prenylated. {ECO:0000269|PubMed:25962623}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10202141
uniprot
proteins
pubmed
10996854
uniprot
proteins
pubmed
11054569
uniprot
proteins
pubmed
11071909
uniprot
proteins
pubmed
12447383
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15878329
uniprot
proteins
pubmed
16034420
uniprot
proteins
pubmed
16332443
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17698061
uniprot
proteins
pubmed
18044744
uniprot
proteins
pubmed
18243103
uniprot
proteins
pubmed
18997784
uniprot
proteins
pubmed
19141279
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20386726
uniprot
proteins
pubmed
20643351
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21411515
uniprot
proteins
pubmed
21822290
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23091056
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23664119
uniprot
proteins
pubmed
23737971
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2501306
uniprot
proteins
pubmed
25492866
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
25962623
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:23091056, ECO:0000269|PubMed:25962623}; Lipid-anchor {ECO:0000269|PubMed:25962623}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:P35279}; Peripheral membrane protein {ECO:0000305}. Note=BICD2 facilitates its targeting to Golgi apparatus membrane. {ECO:0000269|PubMed:25962623}.; SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus membrane {ECO:0000269|PubMed:11071909}; Lipid-anchor {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus membrane {ECO:0000269|PubMed:11071909}; Lipid-anchor {ECO:0000305}.
uniprot
proteins