PTPN13
entrez
5783
canonical
uniprot
Q12923
canonical
ensembl
ENSG00000163629
resolver
ensp
ENSP00000322675
resolver
ensp
ENSP00000394794
resolver
ensp
ENSP00000407249
resolver
ensp
ENSP00000408368
resolver
ensp
ENSP00000530828
resolver
ensp
ENSP00000530829
resolver
ensp
ENSP00000530830
resolver
ensp
ENSP00000530831
resolver
ensp
ENSP00000610510
resolver
ensp
ENSP00000610511
resolver
ensp
ENSP00000610513
resolver
ensp
ENSP00000610517
resolver
ensp
ENSP00000623581
resolver
genesymbol
PTPN13
resolver
genesymbol_syn
PNP1
resolver
genesymbol_syn
PTP1E
resolver
genesymbol_syn
PTPL1
resolver
hgnc
HGNC:9646
resolver
uniprot
B2RTR0
resolver
uniprot
Q15159
resolver
uniprot
Q15263
resolver
uniprot
Q15264
resolver
uniprot
Q15265
resolver
uniprot
Q15674
resolver
uniprot
Q16826
resolver
uniprot
Q8IWH7
resolver
uniprot
Q9NYN9
resolver
uniprot
Q9UDA8
resolver
uniprot_entry
PTN13_HUMAN
resolver
uniprot_sec
B2RTR0
resolver
uniprot_sec
Q15159
resolver
uniprot_sec
Q15263
resolver
uniprot_sec
Q15264
resolver
uniprot_sec
Q15265
resolver
uniprot_sec
Q15674
resolver
uniprot_sec
Q16826
resolver
uniprot_sec
Q8IWH7
resolver
uniprot_sec
Q9NYN9
resolver
uniprot_sec
Q9UDA8
resolver
amino_acid_sequence
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNLSGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKSMGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTSGPEKKPIPGIDVLSKKKIWASSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIALDIFGPQKMDPIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPSIISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIMLKRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFGPEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}.
uniprot
proteins
mass_dalton
276906
uniprot
proteins
mutagenesis
MUTAGEN 2154; /note="D->H: No effect on substrate affinity."; /evidence="ECO:0000269|PubMed:15611135"; MUTAGEN 2205; /note="R->W: No effect on substrate affinity."; /evidence="ECO:0000269|PubMed:15611135"; MUTAGEN 2221; /note="Q->M: Reduces substrate affinity 2 fold."; /evidence="ECO:0000269|PubMed:15611135"; MUTAGEN 2307; /note="M->T: Reduces substrate affinity 7 fold."; /evidence="ECO:0000269|PubMed:15611135"; MUTAGEN 2408; /note="C->S: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:15611135"; MUTAGEN 2444; /note="R->E: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:15611135"; MUTAGEN 2444; /note="R->K: Reduces substrate affinity 7 fold."; /evidence="ECO:0000269|PubMed:15611135"; MUTAGEN 2444; /note="R->Q: Strongly decreases catalytic activity."; /evidence="ECO:0000269|PubMed:15611135"; MUTAGEN 2448; /note="H->A: Reduces substrate affinity 2 fold."; /evidence="ECO:0000269|PubMed:15611135"; MUTAGEN 2449; /note="G->V: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:15611135"; MUTAGEN 2474; /note="E->D: No effect on substrate affinity."; /evidence="ECO:0000269|PubMed:15611135
uniprot
proteins
protein_family
Non-receptor class subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
10400701
uniprot
proteins
pubmed
10544233
uniprot
proteins
pubmed
10704206
uniprot
proteins
pubmed
10826496
uniprot
proteins
pubmed
11356191
uniprot
proteins
pubmed
12095257
uniprot
proteins
pubmed
12436199
uniprot
proteins
pubmed
14516276
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15611135
uniprot
proteins
pubmed
19307596
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23108400
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23604317
uniprot
proteins
pubmed
29043977
uniprot
proteins
pubmed
7536343
uniprot
proteins
pubmed
7929060
uniprot
proteins
pubmed
8071359
uniprot
proteins
pubmed
8287977
uniprot
proteins
pubmed
8483328
uniprot
proteins
pubmed
9305890
uniprot
proteins
sequence_length
2485
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11356191}. Nucleus {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:11356191}. Cell projection, lamellipodium {ECO:0000269|PubMed:11356191}. Note=Colocalizes with F-actin (PubMed:10826496). Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover (PubMed:11356191). {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:11356191}.
uniprot
proteins