GEMIN6
entrez
79833
canonical
uniprot
Q8WXD5
canonical
ensembl
ENSG00000152147
resolver
ensp
ENSP00000281950
resolver
ensp
ENSP00000581147
resolver
ensp
ENSP00000581148
resolver
ensp
ENSP00000607646
resolver
ensp
ENSP00000607647
resolver
ensp
ENSP00000624717
resolver
enst
ENST00000281950
resolver
enst
ENST00000911088
resolver
enst
ENST00000911089
resolver
enst
ENST00000937587
resolver
enst
ENST00000937588
resolver
enst
ENST00000954658
resolver
genesymbol
GEMIN6
resolver
hgnc
HGNC:20044
resolver
uniprot
B2RDP8
resolver
uniprot
Q53SI5
resolver
uniprot
Q8WVB4
resolver
uniprot
Q9H5G6
resolver
uniprot_entry
GEMI6_HUMAN
resolver
uniprot_sec
B2RDP8
resolver
uniprot_sec
Q53SI5
resolver
uniprot_sec
Q8WVB4
resolver
uniprot_sec
Q9H5G6
resolver
amino_acid_sequence
MSEWMKKGPLEWQDYIYKEVRVTASEKNEYKGWVLTTDPVSANIVLVNFLEDGSMSVTGIMGHAVQTVETMNEGDHRVREKLMHLFTSGDCKAYSPEDLEERKNSLKKWLEKNHIPITEQGDAPRTLCVAGVLTIDPPYGPENCSSSNEIILSRVQDLIEGHLTASQ
uniprot
proteins
function
FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. {ECO:0000269|PubMed:11748230, ECO:0000269|PubMed:18984161}.
uniprot
proteins
mass_dalton
18824
uniprot
proteins
pubmed
11748230
uniprot
proteins
pubmed
12065586
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15939020
uniprot
proteins
pubmed
16314521
uniprot
proteins
pubmed
17178713
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18984161
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
33754639
uniprot
proteins
sequence_length
167
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:11748230}. Nucleus, gem {ECO:0000269|PubMed:11748230}. Cytoplasm {ECO:0000269|PubMed:11748230}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
uniprot
proteins