PYDC1
entrez
260434
canonical
uniprot
Q8WXC3
canonical
ensembl
ENSG00000169900
resolver
ensp
ENSP00000304336
resolver
ensp
ENSP00000598175
resolver
enst
ENST00000302964
resolver
enst
ENST00000928116
resolver
genesymbol
PYDC1
resolver
genesymbol_syn
ASC2
resolver
genesymbol_syn
ASCI
resolver
genesymbol_syn
POP1
resolver
genesymbol_syn
PYC1
resolver
hgnc
HGNC:30261
resolver
uniprot
B2R8L4
resolver
uniprot
Q8NFP8
resolver
uniprot_entry
PYDC1_HUMAN
resolver
uniprot_sec
B2R8L4
resolver
uniprot_sec
Q8NFP8
resolver
amino_acid_sequence
MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASYYEDYAAELVVAVLRDMRMLEEAARLQRAA
uniprot
proteins
function
FUNCTION: Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS. {ECO:0000269|PubMed:12656673, ECO:0000269|PubMed:24871464}.
uniprot
proteins
mass_dalton
10107
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:12656673}.
uniprot
proteins
pubmed
11786556
uniprot
proteins
pubmed
12656673
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16905547
uniprot
proteins
pubmed
17178784
uniprot
proteins
pubmed
24871464
uniprot
proteins
sequence_length
89
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12656673}. Note=Recruited to specks formed by PYCARD within the cytoplasm. {ECO:0000269|PubMed:17178784}.
uniprot
proteins