TMEM47
entrez
83604
canonical
uniprot
Q9BQJ4
canonical
ensembl
ENSG00000147027
resolver
ensp
ENSP00000275954
resolver
enst
ENST00000275954
resolver
genesymbol
TMEM47
resolver
genesymbol_syn
BCMP1
resolver
genesymbol_syn
TM4SF10
resolver
hgnc
HGNC:18515
resolver
uniprot
Q5JR44
resolver
uniprot_entry
TMM47_HUMAN
resolver
uniprot_sec
Q5JR44
resolver
amino_acid_sequence
MASAGSGMEEVRVSVLTPLKLVGLVCIFLALCLDLGAVLSPAWVTADHQYYLSLWESCRKPASLDIWHCESTLSSDWQIATLALLLGGAAIILIAFLVGLISICVGSRRRFYRPVAVMLFAAVVLQVCSLVLYPIKFIETVSLKIYHEFNWGYGLAWGATIFSFGGAILYCLNPKNYEDYY
uniprot
proteins
function
FUNCTION: Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity). {ECO:0000250|UniProtKB:Q9JJG6, ECO:0000250|UniProtKB:Q9XSV3}.
uniprot
proteins
mass_dalton
19998
uniprot
proteins
protein_family
TMEM47 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24603971
uniprot
proteins
pubmed
25489052
uniprot
proteins
sequence_length
181
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9XSV3}. Note=Colocalizes with FYB1 at cell-cell contacts in podocytes. {ECO:0000250|UniProtKB:Q9JJG6}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 83..103; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 152..172; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins