Nfkbie
entrez
18037
canonical
uniprot
O54910
canonical
ensembl
ENSMUSG00000023947
resolver
ensp
ENSMUSP00000024742
resolver
ensp
ENSMUSP00000156580
resolver
enst
ENSMUST00000024742
resolver
enst
ENSMUST00000233929
resolver
genesymbol
Nfkbie
resolver
genesymbol_syn
Ikbe
resolver
uniprot
A0A3B2WAY2
resolver
uniprot
Q3U686
resolver
uniprot
Q9CZZ9
resolver
uniprot
Q9D7U3
resolver
uniprot_entry
A0A3B2WAY2_MOUSE
resolver
uniprot_entry
IKBE_MOUSE
resolver
uniprot_sec
Q3U686
resolver
uniprot_sec
Q9CZZ9
resolver
uniprot_sec
Q9D7U3
resolver
amino_acid_sequence
MSDARKGPDEADDSQCDSGIESLRSLRSLPEPTAAPGSGSSQSGCPQPWRHAPETHKEPEKEDADGERADSTYASSSLTESFPLLERPEAKDPSPPAPGSPLPPAGVLSPQQLEALTYISEDGDTLLHLAVIHEAPSVLFCCLAFLPQEVLDIQNNLYQTALHLAVHLDQPDVVRALVLKGASRILQDQHGDTALHVACRRQNLACACCLLEEQPEPGRQLSHPLDLQLKNWQGLACLHIATLQRNQPLIELLLQNGADIDVQEGTSGKTALHLAVETQERSLVQFLLQAGARVDARMLNGCTPLHLAAGRGLNSISSTLCEAGADSLLLNVEDETPQDLAEDLLSYLPFDDLKISGKPLLCTD
uniprot
proteins
function
FUNCTION: Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:32170099). Sequestered complexes include NFKB1/p50-RELA/p65 and NFKB1/p50-REL/c-Rel complexes (By similarity). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (PubMed:32170099). {ECO:0000250|UniProtKB:O00221, ECO:0000269|PubMed:32170099}.
uniprot
proteins
mass_dalton
39200
uniprot
proteins
post_translational_modification
PTM: Serine phosphorylated; followed by proteasome-dependent degradation.
uniprot
proteins
protein_family
NF-kappa-B inhibitor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32170099
uniprot
proteins
pubmed
9405619
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins