SLC35B2
entrez
347734
canonical
uniprot
Q8TB61
canonical
ensembl
ENSG00000157593
resolver
ensp
ENSP00000377401
resolver
ensp
ENSP00000440340
resolver
ensp
ENSP00000443845
resolver
ensp
ENSP00000480681
resolver
genesymbol
SLC35B2
resolver
genesymbol_syn
PAPST1
resolver
hgnc
HGNC:16872
resolver
uniprot
B4DDM2
resolver
uniprot
B4DDU9
resolver
uniprot
F5H7Y9
resolver
uniprot
Q2VY06
resolver
uniprot
Q53GA3
resolver
uniprot
Q5T9W1
resolver
uniprot
Q5T9W2
resolver
uniprot
Q7Z2G3
resolver
uniprot
Q8NBK6
resolver
uniprot
Q96AR6
resolver
uniprot_entry
S35B2_HUMAN
resolver
uniprot_sec
B4DDM2
resolver
uniprot_sec
B4DDU9
resolver
uniprot_sec
F5H7Y9
resolver
uniprot_sec
Q2VY06
resolver
uniprot_sec
Q53GA3
resolver
uniprot_sec
Q5T9W1
resolver
uniprot_sec
Q5T9W2
resolver
uniprot_sec
Q7Z2G3
resolver
uniprot_sec
Q8NBK6
resolver
uniprot_sec
Q96AR6
resolver
amino_acid_sequence
MDARWWAVVVLAAFPSLGAGGETPEAPPESWTQLWFFRFVVNAAGYASFMVPGYLLVQYFRRKNYLETGRGLCFPLVKACVFGNEPKASDEVPLAPRTEAAETTPMWQALKLLFCATGLQVSYLTWGVLQERVMTRSYGATATSPGERFTDSQFLVLMNRVLALIVAGLSCVLCKQPRHGAPMYRYSFASLSNVLSSWCQYEALKFVSFPTQVLAKASKVIPVMLMGKLVSRRSYEHWEYLTATLISIGVSMFLLSSGPEPRSSPATTLSGLILLAGYIAFDSFTSNWQDALFAYKMSSVQMMFGVNFFSCLFTVGSLLEQGALLEGTRFMGRHSEFAAHALLLSICSACGQLFIFYTIGQFGAAVFTIIMTLRQAFAILLSCLLYGHTVTVVGGLGVAVVFAALLLRVYARGRLKQRGKKAVPVESPVQKV
uniprot
proteins
disease_involvement
DISEASE: Leukodystrophy, hypomyelinating, 26, with chondrodysplasia (HLD26) [MIM:620269]: A form of hypomyelinating leukodystrophy, a group of heterogeneous disorders characterized by persistent deficit of myelin observed on brain imaging. HLD26 is an autosomal recessive form characterized by severe psychomotor delay, limited or absent speech, abnormal development of brain white matter, corpus callosum hypoplasia, and cerebral atrophy. Other features include pre- and postnatal growth retardation, chondrodysplasia, and early-onset scoliosis. {ECO:0000269|PubMed:35325049}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Probably functions as a 3'-phosphoadenylyl sulfate:adenosine 3',5'-bisphosphate antiporter at the Golgi membranes. Mediates the transport from the cytosol into the lumen of the Golgi of 3'-phosphoadenylyl sulfate/adenosine 3'-phospho 5'-phosphosulfate (PAPS), a universal sulfuryl donor for sulfation events that take place in that compartment. {ECO:0000269|PubMed:12716889}.
uniprot
proteins
mass_dalton
47515
uniprot
proteins
protein_family
Nucleotide-sugar transporter family
uniprot
proteins
protein_family
SLC35B subfamily
uniprot
proteins
pubmed
12716889
uniprot
proteins
pubmed
12761501
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
35325049
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:12716889, ECO:0000269|PubMed:35325049}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 109..129; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 154..174; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 299..319; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 353..373; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 387..407; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins