Itgal
entrez
16408
canonical
uniprot
P24063
canonical
ensembl
ENSMUSG00000030830
resolver
ensp
ENSMUSP00000101913
resolver
ensp
ENSMUSP00000113946
resolver
ensp
ENSMUSP00000199598
resolver
genesymbol
Itgal
resolver
genesymbol_syn
Lfa-1
resolver
genesymbol_syn
Ly-15
resolver
uniprot
B7ZN92
resolver
uniprot
E9Q5M7
resolver
uniprot
E9QNL8
resolver
uniprot
Q3TB85
resolver
uniprot
Q3U159
resolver
uniprot_entry
B7ZN92_MOUSE
resolver
uniprot_entry
ITAL_MOUSE
resolver
uniprot_entry
Q3TB85_MOUSE
resolver
uniprot_sec
E9Q5M7
resolver
uniprot_sec
E9QNL8
resolver
uniprot_sec
Q3U159
resolver
amino_acid_sequence
MSFRIAGPRLLLLGLQLFAKAWSYNLDTRPTQSFLAQAGRHFGYQVLQIEDGVVVGAPGEGDNTGGLYHCRTSSEFCQPVSLHGSNHTSKYLGMTLATDAAKGSLLACDPGLSRTCDQNTYLSGLCYLFPQSLEGPMLQNRPAYQECMKGKVDLVFLFDGSQSLDRKDFEKILEFMKDVMRKLSNTSYQFAAVQFSTDCRTEFTFLDYVKQNKNPDVLLGSVQPMFLLTNTFRAINYVVAHVFKEESGARPDATKVLVIITDGEASDKGNISAAHDITRYIIGIGKHFVSVQKQKTLHIFASEPVEEFVKILDTFEKLKDLFTDLQRRIYAIEGTNRQDLTSFNMELSSSGISADLSKGHAVVGAVGAKDWAGGFLDLREDLQGATFVGQEPLTSDVRGGYLGYTVAWMTSRSSRPLLAAGAPRYQHVGQVLLFQAPEAGGRWNQTQKIEGTQIGSYFGGELCSVDLDQDGEAELLLIGAPLFFGEQRGGRVFTYQRRQSLFEMVSELQGDPGYPLGRFGAAITALTDINGDRLTDVAVGAPLEEQGAVYIFNGKPGGLSPQPSQRIQGAQVFPGIRWFGRSIHGVKDLGGDRLADVVVGAEGRVVVLSSRPVVDVVTELSFSPEEIPVHEVECSYSAREEQKHGVKLKACFRIKPLTPQFQGRLLANLSYTLQLDGHRMRSRGLFPDGSHELSGNTSITPDKSCLDFHFHFPICIQDLISPINVSLNFSLLEEEGTPRDQKVGRAMQPILRPSIHTVTKEIPFEKNCGEDKKCEANLTLSSPARSGPLRLMSSASLAVEWTLSNSGEDAYWVRLDLDFPRGLSFRKVEMLQPHSRMPVSCEELTEGSSLLTKTLKCNVSSPIFKAGQEVSLQVMFNTLLNSSWEDFVELNGTVHCENENSSLQEDNSAATHIPVLYPVNILTKEQENSTLYISFTPKGPKTQQVQHVYQVRIQPSAYDHNMPTLEALVGVPWPHSEDPITYTWSVQTDPLVTCHSEDLKRPSSEAEQPCLPGVQFRCPIVFRREILIQVTGTVELSKEIKASSTLSLCSSLSVSFNSSKHFHLYGSKASEAQVLVKVDLIHEKEMLHVYVLSGIGGLVLLFLIFLALYKVGFFKRNLKEKMEADGGVPNGSPPEDTDPLAVPGEETKDMGCLEPLRESDKD
uniprot
proteins
function
FUNCTION: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4 (PubMed:2051027). Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:16234355, PubMed:24158516). Acts as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion (By similarity). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (PubMed:25108025). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (By similarity). Integrins ITGAL:ITGB2 functions as a receptor of the neuron-specific adhesion molecule ICAM5 ensuring neuron cell-leukocyte adhesion. Integrin ITGAL/ITGB2 that functions as a signaling receptor of ICAM2, ensuring leukocyte cell-cell adhesion on resting cells (By similarity). {ECO:0000250|UniProtKB:P20701, ECO:0000269|PubMed:16234355, ECO:0000269|PubMed:2051027, ECO:0000269|PubMed:24158516, ECO:0000269|PubMed:25108025, ECO:0000269|PubMed:29100055}.
uniprot
proteins
mass_dalton
128314
uniprot
proteins
post_translational_modification
PTM: In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for the activation by some physiological agents. {ECO:0000250|UniProtKB:P20701}.
uniprot
proteins
protein_family
Integrin alpha chain family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16234355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
2051027
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24158516
uniprot
proteins
pubmed
25108025
uniprot
proteins
pubmed
29100055
uniprot
proteins
pubmed
3887182
uniprot
proteins
sequence_length
1162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20701}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000250|UniProtKB:P20701}. Note=Upon antigen recognition by the TCR, is recruited to lipid rafts. {ECO:0000250|UniProtKB:P20701}.
uniprot
proteins
transmembrane_region
TRANSMEM 1089..1109; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins