Itpkc
entrez
308451
canonical
uniprot
Q80ZG2
canonical
ensembl
ENSRNOG00000013945
resolver
ensembl
ENSRNOG00055033563
resolver
ensp
ENSRNOP00000084385
resolver
ensp
ENSRNOP00055047858
resolver
enst
ENSRNOT00000100648
resolver
enst
ENSRNOT00055058018
resolver
genesymbol
Itpkc
resolver
genesymbol_syn
Ip3kc
resolver
uniprot_entry
IP3KC_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by calcium/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4. {ECO:0000269|PubMed:12649294}.
uniprot
proteins
amino_acid_sequence
MRRCPCRGSLSEAEAGALPAEARMGLEALRGGRRRQPGLQRPGPGAGGPTGRPEGGGPRAWIEGFSLHSEAERTDFGPAPCPDGPQAEPCGDEHEECEAAGLGVASEKPSQNKELDGSNLQTHPKLSSPLAEMEMAGSWTDGFRTDLHRPDLQARPKRASLCTQPGFDESWTELDRSELWQTLPERDKPWVDHLRTHQDMSRLQNHPACPSPEPSAGTSCKELSADGSRTPHDTDGFWIESQTDGSLIGPSTQTACRQPANDGFSAQDTDGTLIQPGTDDGPWVDSVLEKSNGDDPLMEPEPRDLVTNLCSHLECSSLCPVPRLIITSESPEPGAQPLGPQARIEGGTGGFSSASSFDESEDDLVAGGGGTSDPEDRSGSKPWKKLKTVLKYSPFVVSFHKHYYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLELLMGDPLRPFVPTYYGMVQRDGQAFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPKPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETLSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVNGDVGILRKYVARLEDLRDTLENSPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQMLSHRLPWAEGNREDGYLWGLDNLICLLQGLAQS
uniprot
proteins
ec_number
2.7.1.127
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (PubMed:12649294). Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. {ECO:0000269|PubMed:12649294}.
uniprot
proteins
mass_dalton
74463
uniprot
proteins
mutagenesis
MUTAGEN 318..326; /note="Missing: No export in the cytoplasm."; /evidence="ECO:0000269|PubMed:12649294"; MUTAGEN 318..321; /note="LCPV->ACPA: No export in the cytoplasm."; /evidence="ECO:0000269|PubMed:12649294
uniprot
proteins
protein_family
Inositol phosphokinase (IPK) family
uniprot
proteins
pubmed
12649294
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
678
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12649294}. Cytoplasm {ECO:0000269|PubMed:12649294}. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.
uniprot
proteins