CALHM6
entrez
441168
canonical
uniprot
Q5R3K3
canonical
ensembl
ENSG00000188820
resolver
ensp
ENSP00000357594
resolver
ensp
ENSP00000357595
resolver
genesymbol
CALHM6
resolver
genesymbol_syn
C6orf187
resolver
genesymbol_syn
FAM26F
resolver
hgnc
HGNC:33391
resolver
uniprot
B9EJB0
resolver
uniprot
Q5R3K4
resolver
uniprot_entry
CAHM6_HUMAN
resolver
uniprot_sec
B9EJB0
resolver
uniprot_sec
Q5R3K4
resolver
amino_acid_sequence
MEKFRAVLDLHVKHHSALGYGLVTLLTAGGERIFSAVAFQCPCSAAWNLPYGLVFLLVPALALFLLGYVLSARTWRLLTGCCSSARASCGSALRGSLVCTQISAAAALAPLTWVAVALLGGAFYECAATGSAAFAQRLCLGRNRSCAAELPLVPCNQAKASDVQDLLKDLKAQSQVLGWILIAVVIIILLIFTSVTRCLSPVSFLQLKFWKIYLEQEQQILKSKATEHATELAKENIKCFFEGSHPKEYNTPSMKEWQQISSLYTFNPKGQYYSMLHKYVNRKEKTHSIRSTEGDTVIPVLGFVDSSGINSTPEL
uniprot
proteins
function
FUNCTION: Pore-forming subunit of an ATP-permeable channel (By similarity). In response to pathogen-derived and proinflammatory stimuli, relocates from intracellular compartments to NK-dendritic cell and NK-macrophage immune synapses where it mediates ATP efflux and NK cell activation involved in antimicrobial and antitumor responses (By similarity). May assemble to form gap junction channel-like structures with gating and ion conductance likely regulated by membrane lipids and voltage rather than by extracellular calcium levels (PubMed:32374262). {ECO:0000250|UniProtKB:Q8C9E8, ECO:0000269|PubMed:32374262}.
uniprot
proteins
mass_dalton
34458
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q8C9E8}.
uniprot
proteins
protein_family
CALHM family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
32374262
uniprot
proteins
sequence_length
315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32374262}; Multi-pass membrane protein {ECO:0000255}. Note=Recruited at immune synapses in response to pathogen-derived and proinflammatory stimuli. {ECO:0000250|UniProtKB:Q8C9E8}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..37; /note="Helical; Name=S1"; /evidence="ECO:0000269|PubMed:32374262, ECO:0007744|PDB:6YTV"; TRANSMEM 47..68; /note="Helical; Name=S2"; /evidence="ECO:0000269|PubMed:32374262, ECO:0007744|PDB:6YTV"; TRANSMEM 103..127; /note="Helical; Name=S3"; /evidence="ECO:0000269|PubMed:32374262, ECO:0007744|PDB:6YTV"; TRANSMEM 170..192; /note="Helical; Name=S4"; /evidence="ECO:0000269|PubMed:32374262, ECO:0007744|PDB:6YTV
uniprot
proteins