TPM3
entrez
7170
canonical
uniprot
P06753
canonical
ensembl
ENSG00000143549
resolver
ensp
ENSP00000271850
resolver
ensp
ENSP00000307712
resolver
ensp
ENSP00000339035
resolver
ensp
ENSP00000357516
resolver
ensp
ENSP00000357517
resolver
ensp
ENSP00000357518
resolver
ensp
ENSP00000357520
resolver
ensp
ENSP00000357521
resolver
ensp
ENSP00000480520
resolver
ensp
ENSP00000498577
resolver
ensp
ENSP00000661365
resolver
ensp
ENSP00000680647
resolver
enst
ENST00000271850
resolver
enst
ENST00000368530
resolver
enst
ENST00000611659
resolver
genesymbol
TPM3
resolver
genesymbol
TPM3nu
resolver
hgnc
HGNC:12012
resolver
uniprot
A0A087WWU8
resolver
uniprot
A0A0S2Z4G4
resolver
uniprot
A0A0S2Z4G8
resolver
uniprot
A0A0S2Z4I4
resolver
uniprot
A0A2R2Y2Q3
resolver
uniprot
A0A499FIP3
resolver
uniprot
B4DQ80
resolver
uniprot
D3DV71
resolver
uniprot
J3KN67
resolver
uniprot
P12324
resolver
uniprot
Q2QD06
resolver
uniprot
Q5VU58
resolver
uniprot
Q5VU63
resolver
uniprot
Q5VU66
resolver
uniprot
Q5VU71
resolver
uniprot
Q5VU72
resolver
uniprot
Q8TCG3
resolver
uniprot
Q969Q2
resolver
uniprot
Q9NQH8
resolver
uniprot_entry
A0A087WWU8_HUMAN
resolver
uniprot_entry
A0A0S2Z4G4_HUMAN
resolver
uniprot_entry
A0A0S2Z4G8_HUMAN
resolver
uniprot_entry
A0A0S2Z4I4_HUMAN
resolver
uniprot_entry
A0A2R2Y2Q3_HUMAN
resolver
uniprot_entry
A0A499FIP3_HUMAN
resolver
uniprot_entry
B4DQ80_HUMAN
resolver
uniprot_entry
J3KN67_HUMAN
resolver
uniprot_entry
TPM3_HUMAN
resolver
uniprot_sec
D3DV71
resolver
uniprot_sec
P12324
resolver
uniprot_sec
Q2QD06
resolver
uniprot_sec
Q5VU58
resolver
uniprot_sec
Q5VU63
resolver
uniprot_sec
Q5VU66
resolver
uniprot_sec
Q5VU71
resolver
uniprot_sec
Q5VU72
resolver
uniprot_sec
Q8TCG3
resolver
uniprot_sec
Q969Q2
resolver
uniprot_sec
Q9NQH8
resolver
amino_acid_sequence
MMEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEELDHALNDMTSI
uniprot
proteins
disease_involvement
DISEASE: Congenital myopathy 4A, autosomal dominant (CMYO4A) [MIM:255310]: A muscular disorder characterized by onset of muscle weakness in infancy or childhood. Most affected individuals show mildly delayed motor development, hypotonia, generalized muscle weakness, and weakness of the proximal limb muscles and neck muscles, resulting in difficulty running and easy fatigability. Many patients have respiratory insufficiency with reduced vital capacity. Skeletal muscle biopsy shows nemaline rod inclusions, subsarcolemmal 'cap' structures, and fiber-type disproportion. {ECO:0000269|PubMed:10587521, ECO:0000269|PubMed:17376686, ECO:0000269|PubMed:18300303, ECO:0000269|PubMed:19487656, ECO:0000269|PubMed:19553118, ECO:0000269|PubMed:19953533, ECO:0000269|PubMed:20951040, ECO:0000269|PubMed:24239060, ECO:0000269|PubMed:24692096, ECO:0000269|PubMed:7704029}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Congenital myopathy 4B, autosomal recessive (CMYO4B) [MIM:609284]: A muscular disorder characterized by muscle weakness appearing in infancy or early childhood. Most affected individuals show congenital contractures, delayed motor development, hypotonia, respiratory insufficiency, generalized muscle weakness, and weakness of the proximal limb muscles and neck muscles, resulting in difficulty walking or inability to walk. Skeletal muscle biopsy shows variable histologic findings, including nemaline rods, type 1 fiber predomination, and centralized nuclei. {ECO:0000269|PubMed:18382475}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=A chromosomal aberration involving TPM3 is found in papillary thyroid carcinomas (PTCs). A rearrangement with NTRK1 generates the TRK fusion transcript by fusing the amino end of isoform 2 of TPM3 to the 3'-end of NTRK1. {ECO:0000269|PubMed:2869410}.
uniprot
proteins
function
FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}.
uniprot
proteins
mass_dalton
32950
uniprot
proteins
protein_family
Tropomyosin family
uniprot
proteins
pubmed
10587521
uniprot
proteins
pubmed
12574106
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16201836
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17376686
uniprot
proteins
pubmed
18300303
uniprot
proteins
pubmed
18382475
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19487656
uniprot
proteins
pubmed
19553118
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19953533
uniprot
proteins
pubmed
20951040
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24239060
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24692096
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2869410
uniprot
proteins
pubmed
3018581
uniprot
proteins
pubmed
3024106
uniprot
proteins
pubmed
3418707
uniprot
proteins
pubmed
35510366
uniprot
proteins
pubmed
7663526
uniprot
proteins
pubmed
7704029
uniprot
proteins
pubmed
8002995
uniprot
proteins
sequence_length
285
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
uniprot
proteins