Gna15
entrez
89788
canonical
uniprot
O88302
canonical
ensembl
ENSRNOG00000005378
resolver
ensp
ENSRNOP00000007202
resolver
enst
ENSRNOT00000007202
resolver
genesymbol
Gna15
resolver
uniprot
G3V6N8
resolver
uniprot_entry
G3V6N8_RAT
resolver
uniprot_entry
GNA15_RAT
resolver
amino_acid_sequence
MARSLTWGCCPWCLTEEEKTAARIDQEINKILLEQKKQERGELKLLLLGPGESGKSTFIKQMRIIHGAGYSEEDRRAFRLLVYQNIFVSMQAMIEAMDRLQIPFSRPDSKQHASLVMTQDPYKVSSFEKPYAVAMQYLWRDAGIRACYERRREFHLLDSAVYYLSHLERIAEDDYIPTAQDVLRSRMPTTGINEYCFSVQKTKLRIVDAGGQKSERKKWIHCFENVIALIYLASLSEYDQCLEENSQENRMKESLALFSTILELPWFKSTSVILFLNKTDILEDKIHTSHLASYFPSFQGPRRDAEAAKRFILDMYARVYASCAEPHDGGRKGSRARRLFAHFTCATDTHSVRSVFKDVRDSVLARYLDEINLL
uniprot
proteins
function
FUNCTION: Member of the G protein alpha subunit family that plays a crucial role in intracellular signaling. Functions as a molecular switch, transducing signals from G protein-coupled receptors (GPCRs) to downstream effectors. In collaboration with the adapter protein TTC1, promotes HRAS activation and ERK1/2 phosphorylation independently of phospholipase Cbeta signaling. Also initiates EMR2-mediated signaling, leading to activation of Akt, MAPK, and NF-kappa-B, which in turn drives macrophage differentiation and inflammatory responses. {ECO:0000250|UniProtKB:P30679}.
uniprot
proteins
mass_dalton
43332
uniprot
proteins
protein_family
G(q) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
pubmed
9685675
uniprot
proteins
sequence_length
374
uniprot
proteins