PHF20
entrez
51230
canonical
uniprot
Q9BVI0
canonical
ensembl
ENSG00000025293
resolver
ensp
ENSP00000363124
resolver
ensp
ENSP00000607546
resolver
ensp
ENSP00000612315
resolver
genesymbol
PHF20
resolver
genesymbol_syn
C20orf104
resolver
genesymbol_syn
GLEA2
resolver
genesymbol_syn
HCA58
resolver
genesymbol_syn
NZF
resolver
genesymbol_syn
TZP
resolver
hgnc
HGNC:16098
resolver
uniprot
A7E235
resolver
uniprot
B2RB56
resolver
uniprot
E1P5S3
resolver
uniprot
Q566Q2
resolver
uniprot
Q5JWY9
resolver
uniprot
Q66K49
resolver
uniprot
Q9BWV4
resolver
uniprot
Q9BXA3
resolver
uniprot
Q9BZW3
resolver
uniprot
Q9H421
resolver
uniprot
Q9H4J6
resolver
uniprot
Q9NZ22
resolver
uniprot_entry
PHF20_HUMAN
resolver
uniprot_sec
A7E235
resolver
uniprot_sec
B2RB56
resolver
uniprot_sec
E1P5S3
resolver
uniprot_sec
Q566Q2
resolver
uniprot_sec
Q5JWY9
resolver
uniprot_sec
Q66K49
resolver
uniprot_sec
Q9BWV4
resolver
uniprot_sec
Q9BXA3
resolver
uniprot_sec
Q9BZW3
resolver
uniprot_sec
Q9H421
resolver
uniprot_sec
Q9H4J6
resolver
uniprot_sec
Q9NZ22
resolver
amino_acid_sequence
MTKHPPNRRGISFEVGAQLEARDRLKNWYPAHIEDIDYEEGKVLIHFKRWNHRYDEWFCWDSPYLRPLEKIQLRKEGLHEEDGSSEFQINEQVLACWSDCRFYPAKVTAVNKDGTYTVKFYDGVVQTVKHIHVKAFSKDQNIVGNARPKETDHKSLSSSPDKREKFKEQRKATVNVKKDKEDKPLKTEKRPKQPDKEGKLICSEKGKVSEKSLPKNEKEDKENISENDREYSGDAQVDKKPENDIVKSPQENLREPKRKRGRPPSIAPTAVDSNSQTLQPITLELRRRKISKGCEVPLKRPRLDKNSSQEKSKNYSENTDKDLSRRRSSRLSTNGTHEILDPDLVVSDLVDTDPLQDTLSSTKESEEGQLKSALEAGQVSSALTCHSFGDGSGAAGLELNCPSMGENTMKTEPTSPLVELQEISTVEVTNTFKKTDDFGSSNAPAVDLDHKFRCKVVDCLKFFRKAKLLHYHMKYFHGMEKSLEPEESPGKRHVQTRGPSASDKPSQETLTRKRVSASSPTTKDKEKNKEKKFKEFVRVKPKKKKKKKKKTKPECPCSEEISDTSQEPSPPKAFAVTRCGSSHKPGVHMSPQLHGPESGHHKGKVKALEEDNLSESSSESFLWSDDEYGQDVDVTTNPDEELDGDDRYDFEVVRCICEVQEENDFMIQCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLEENYSHQNAKKIVATHQLLGDVQRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPSYRTLNGAVEKPRPLALPLPRSVEESYITSEHCYQKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDPKPGSPKVKEYVSKKALPEEAPARKLLDRGGEGLLSSQHQWQFNLLTHVESLQDEVTHRMDSIEKELDVLESWLDYTGELEPPEPLARLPQLKHCIKQLLMDLGKVQQIALCCST
uniprot
proteins
function
FUNCTION: Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}.
uniprot
proteins
mass_dalton
115386
uniprot
proteins
mutagenesis
MUTAGEN 96; /note="C->S: Abolishes homodimerization."; /evidence="ECO:0000269|PubMed:22864287"; MUTAGEN 97; /note="W->A: Abolishes interaction with methylated p53."; /evidence="ECO:0000269|PubMed:22864287"; MUTAGEN 100; /note="C->S: Abolishes homodimerization."; /evidence="ECO:0000269|PubMed:22864287"; MUTAGEN 103; /note="Y->A: Abolishes interaction with methylated p53."; /evidence="ECO:0000269|PubMed:22864287
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by TRIM26; leading to proteasomal degradation. {ECO:0000269|PubMed:23452852}.
uniprot
proteins
pubmed
11703362
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12097419
uniprot
proteins
pubmed
12800201
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15960975
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20018852
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22449972
uniprot
proteins
pubmed
22864287
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23452852
uniprot
proteins
sequence_length
1012
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20018852}.
uniprot
proteins