Rhbdf1
entrez
303008
canonical
uniprot
Q499S9
canonical
ensembl
ENSRNOG00000020594
resolver
ensembl
ENSRNOG00065010329
resolver
ensp
ENSRNOP00000027965
resolver
ensp
ENSRNOP00000112746
resolver
ensp
ENSRNOP00065012728
resolver
enst
ENSRNOT00000027965
resolver
enst
ENSRNOT00000145512
resolver
enst
ENSRNOT00065016685
resolver
genesymbol
Rhbdf1
resolver
uniprot
A0ABK0LP41
resolver
uniprot_entry
A0ABK0LP41_RAT
resolver
uniprot_entry
RHDF1_RAT
resolver
amino_acid_sequence
MSEARRDSTSSLQRKKPPWLKLDIPAVVPPAAEEPSFLQPLRRQAFLRSVSMPAETARVPSPHHEPRRLALQRQTSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRMADDTADGLSAPHTPVTPGAASLCSFSSSRSGFNRLPRRRKRESVAKMSFRAAAALVKGRSIRDGTLRRGQRRSFTPASFLEEDMVDFPDELDTSFFAREGVLHEELSTYPDEVFESPSEAALKDWEKAPDQADLTGGALDRSELERSHLMLPLERGWRKQKEGGTLAPQPKVRLRQEVVSAAGPRRGQRIAVPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSYVKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGIAPVGFSQHETVDSVLRKRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHNFILAAREREKHSACCVRNDRSGCVQTSKEECSSTLAVWVKWPVHPSAPDLAGNKRQFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKNSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMKGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSVCFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFAFGLLPWIDNFAHISGFVSGLFLSFAFLPYISFGKFDLYRKRCQIIIFQAVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTDKFCEKYELDAQLH
uniprot
proteins
function
FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q96CC6}.
uniprot
proteins
mass_dalton
97262
uniprot
proteins
protein_family
Peptidase S54 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
856
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96CC6}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q96CC6}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly localized in the endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q96CC6}.
uniprot
proteins
transmembrane_region
TRANSMEM 413..433; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 657..677; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 693..713; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 716..736; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 748..768; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 774..794; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 805..825; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins