Pus1
entrez
304567
canonical
uniprot
Q4KM92
canonical
ensembl
ENSRNOG00000037500
resolver
ensembl
ENSRNOG00055001822
resolver
ensembl
ENSRNOG00060004370
resolver
ensembl
ENSRNOG00065006419
resolver
ensp
ENSRNOP00000053623
resolver
ensp
ENSRNOP00000090656
resolver
ensp
ENSRNOP00055002230
resolver
ensp
ENSRNOP00060005580
resolver
ensp
ENSRNOP00065007188
resolver
enst
ENSRNOT00000056780
resolver
enst
ENSRNOT00000102180
resolver
enst
ENSRNOT00055002963
resolver
enst
ENSRNOT00060007352
resolver
enst
ENSRNOT00065009886
resolver
genesymbol
Pus1
resolver
uniprot
A0A8I6ANT6
resolver
uniprot
B1WBN5
resolver
uniprot_entry
A0A8I6ANT6_RAT
resolver
uniprot_entry
B1WBN5_RAT
resolver
uniprot_entry
PUS1_RAT
resolver
amino_acid_sequence
MGFPRLWAALLRAWGRWTARPGPRVPGLPPMAGNKVPPALPSHQPDRKGRGGWVWEETEHPAKRVKGGEDEEPPRKLPKRKIVLLMAYSGKGYHGMQRNLGSSQFRTIEDDLVSALVQAGCIPENHGTDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILDKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPTFAFAHKDRDVQDESYRLSAETLQQVNRLLGCYKGTHNFHNFTSQKGPREPSARRYILEMYCEEPFVREGLEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGEEKVDVPKAPGLGLVLERVHFEKYNQRFGSDGLHEPLDWAQEEGKVTAFKEQYIYPTIVSTERDERSMAQWLNTLPIHNFSGTALGADDTGAKVPSSLEGSEGDGDTD
uniprot
proteins
ec_number
5.4.99.-
uniprot
proteins
ec_number
5.4.99.12
uniprot
proteins
function
FUNCTION: Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA. {ECO:0000250|UniProtKB:Q9Y606}.
uniprot
proteins
mass_dalton
47515
uniprot
proteins
protein_family
TRNA pseudouridine synthase TruA family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y606}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y606}. Mitochondrion {ECO:0000250|UniProtKB:Q9Y606}.
uniprot
proteins