Q8CDI2
uniprot
Q8CDI2
canonical
amino_acid_sequence
MDSSAVTVKGLSLIDFCSTSSFKYRGHHELSESCSLNKKEEEPMLTCEHPETPSLGSPNSAVSPSQIMKSVSLRKEKDKSPELCETPKLRRKKCTLRRRLDFSFPLLKGDSDSQSRSLESNISQGVSLEKHLPGSTSGFPKEDNFSPLVTSTIKTEDVVSNSQNSRLHFSQHKTSTIEDSKDNCGLFEVECLSPIEGNDFKDSITHFSDSSLSVSDENTCPELLGSCGSQTTYGADVTTSVTPVSSLIAKIKFNGNQTLDSSGEVRDSLFTPEDSGFCSLSWDKSEDFLSDQEGSFQELLQKHRVTPKVGDQVKKPKHFGRLRRLSTLQEQGQSEDEMQTVHPNSDSGVLESLQGSEEKRGNLALSFKDLSNTPALQLVQELFMKSKRKRSQQEDDQEFFEDRDEGKIARLQRVLAGLIGKKMGIEQLDILTELQYRNLKHILAMVLESLTSESLYSAWNVSRNWREIVAQDKKANRRRKLYIIQLRASAQGAAVLRVQDAATRLCLLSRLALRSVQAQAQAPSGEQVPTLSPWGDVLTPVASSSLTHLRSKQEQYVKVARTLFTDEALKPCPRCQSPAKYQPHKKRGLCSRLACGFDFCVLCLCAYHGSEDCRRGSAKARGSKDVLPGSAQSKRNLKRL
uniprot
proteins
function
FUNCTION: Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (PubMed:16456547). Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis (PubMed:28723571). {ECO:0000269|PubMed:16456547, ECO:0000269|PubMed:28723571}.
uniprot
proteins
mass_dalton
71171
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Thr-176 and Ser-275 in response to calcium, which is a prerequisite for ubiquitination and proteasomal degradation. {ECO:0000250}.; PTM: Ubiquitinated in response to calcium, which promotes proteasomal degradation. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16456547
uniprot
proteins
pubmed
28723571
uniprot
proteins
sequence_length
640
uniprot
proteins