Nr1i2
entrez
84385
canonical
uniprot
Q9R1A7
canonical
ensembl
ENSRNOG00000002906
resolver
ensembl
ENSRNOG00055016327
resolver
ensembl
ENSRNOG00060007971
resolver
ensembl
ENSRNOG00065019128
resolver
ensp
ENSRNOP00000003934
resolver
ensp
ENSRNOP00055022215
resolver
ensp
ENSRNOP00060009963
resolver
ensp
ENSRNOP00065025671
resolver
enst
ENSRNOT00000003934
resolver
enst
ENSRNOT00055027681
resolver
enst
ENSRNOT00060013142
resolver
enst
ENSRNOT00065032160
resolver
genesymbol
Nr1i2
resolver
genesymbol_syn
Pxr
resolver
uniprot_entry
NR1I2_RAT
resolver
amino_acid_sequence
MRPEERWNHVGLVQREEADSVLEEPINVDEEDGGLQICRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFRKGTCEITRKTRRQCQACRLRKCLESGMKKEMIMSDAAVEQRRALIKRKKREKIEAPPPGGQGLTEEQQALIQELMDAQMQTFDTTFSHFKDFRLPAVFHSDCELPEVLQASLLEDPATWSQIMKDSVPMKISVQLRGEDGSIWNYQPPSKSDGKEIIPLLPHLADVSTYMFKGVINFAKVISHFRELPIEDQISLLKGATFEMCILRFNTMFDTETGTWECGRLAYCFEDPNGGFQKLLLDPLMKFHCMLKKLQLREEEYVLMQAISLFSPDRPGVVQRSVVDQLQERFALTLKAYIECSRPYPAHRFLFLKIMAVLTELRSINAQQTQQLLRIQDTHPFATPLMQELFSSTDG
uniprot
proteins
function
FUNCTION: Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. Activated by a broad range of endogenous steroids (e.g. pregnenolone, progesterone) and xenobiotics, including the antibiotic rifampicin and certain plant-derived metabolites. Upon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation. Target genes include cytochrome P450 enzymes such as CYP3A4 and ATP-binding cassette transporters including ABCB1/MDR1. {ECO:0000250|UniProtKB:O75469}.
uniprot
proteins
mass_dalton
49660
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKC at Thr-405. {ECO:0000250|UniProtKB:O75469}.; PTM: Ubiquitinated by RBCK1, leading to proteasomal degradation. Ubiquitinated in a FBXO44-dependent manner also leads to proteasomal degradation. {ECO:0000250|UniProtKB:O75469}.
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10415106
uniprot
proteins
sequence_length
431
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
uniprot
proteins