Rnf135
entrez
303350
canonical
uniprot
Q5M929
canonical
ensembl
ENSRNOG00000081456
resolver
ensp
ENSRNOP00000088068
resolver
genesymbol
Rnf135
resolver
uniprot_entry
RN135_RAT
resolver
amino_acid_sequence
MAAACPGTAVPVWLSEEDLSCIICQGLLDWPTTLPCGHSFCLQCLKDLWVSKRAGVDSCPWACPICRKGPSAKPVLHKNPLLQDLVDKYRQAALELEAGPEPAPVPRSLCTPTPPQVTVQKSTTQVVQELTELVGQLVDIVKSLQTQRPSLASGLDNALGILHMDSSSEEEYPLDSPKLVTFSASQKKIQEILRDLEKIQETLQGSVTGNEAPKKQVEEMASSVGLLPDQRYPVSRKASQFSLWAISPTFDLRSLSCNLEVSNNCRMVTVSRALQPYHWSSERFSISQVLCSQAFSSGQKYWEVDTRNCSHWAVGVASWGMKRDKMLGRTMDSWCIEWRGPSQFSAWAMMKKTDLSSGPPEVVGVWLDLELGKLAFYSVADQERPLYECEVSSSSPLHPAFWLYGLTPGNYLEIL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response. Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway. Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway. This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway. Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway. {ECO:0000250|UniProtKB:Q8IUD6}.
uniprot
proteins
mass_dalton
46012
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8IUD6}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8IUD6}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q8IUD6}.
uniprot
proteins