PPBP
entrez
5473
canonical
uniprot
P02775
canonical
ensembl
ENSG00000163736
resolver
ensp
ENSP00000296028
resolver
ensp
ENSP00000520613
resolver
enst
ENST00000296028
resolver
enst
ENST00000716905
resolver
genesymbol
PPBP
resolver
genesymbol_syn
CTAP3
resolver
genesymbol_syn
CXCL7
resolver
genesymbol_syn
SCYB7
resolver
genesymbol_syn
TGB1
resolver
genesymbol_syn
THBGB1
resolver
hgnc
HGNC:9240
resolver
uniprot
B2R5F3
resolver
uniprot
Q6IBJ8
resolver
uniprot_entry
CXCL7_HUMAN
resolver
uniprot_sec
B2R5F3
resolver
uniprot_sec
Q6IBJ8
resolver
amino_acid_sequence
MSLRLDTTPSCNSARPLHALQVLLLLSLLLTALASSTKGQTKRNLAKGKEESLDSDLYAELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDESAD
uniprot
proteins
function
FUNCTION: LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO:0000269|PubMed:10877842, ECO:0000269|PubMed:7890771, ECO:0000269|PubMed:8950790, ECO:0000269|PubMed:9794434}.
uniprot
proteins
mass_dalton
13894
uniprot
proteins
post_translational_modification
PTM: Proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III (CTAP-III) (low-affinity platelet factor IV (LA-PF4)).; PTM: Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets along with platelet factor 4 and platelet-derived growth factor.; PTM: NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils. {ECO:0000269|PubMed:9794434}.; PTM: NAP-2(73) and NAP-2(74) seem not be produced by proteolytical processing of secreted precursors but are released in an active form from platelets. {ECO:0000269|PubMed:9794434}.
uniprot
proteins
protein_family
Intercrine alpha (chemokine CxC) family
uniprot
proteins
pubmed
10877842
uniprot
proteins
pubmed
11468158
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
1826003
uniprot
proteins
pubmed
2007144
uniprot
proteins
pubmed
2406364
uniprot
proteins
pubmed
2423119
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2522778
uniprot
proteins
pubmed
2713489
uniprot
proteins
pubmed
2783111
uniprot
proteins
pubmed
6572368
uniprot
proteins
pubmed
7706245
uniprot
proteins
pubmed
77677
uniprot
proteins
pubmed
7890771
uniprot
proteins
pubmed
8034022
uniprot
proteins
pubmed
8950790
uniprot
proteins
pubmed
9794434
uniprot
proteins
sequence_length
128
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins