Fancm
entrez
104806
canonical
uniprot
Q8BGE5
canonical
ensembl
ENSMUSG00000055884
resolver
ensp
ENSMUSP00000054797
resolver
genesymbol
Fancm
resolver
genesymbol_syn
Kiaa1596
resolver
uniprot
Q69ZF5
resolver
uniprot
Q8BKB7
resolver
uniprot
Q8BUA8
resolver
uniprot_entry
FANCM_MOUSE
resolver
uniprot_sec
Q69ZF5
resolver
uniprot_sec
Q8BKB7
resolver
uniprot_sec
Q8BUA8
resolver
amino_acid_sequence
MSGRQRTLFQTWGPSLVRGSGDSGCGQPRSPAMAEALPEEDDEVLLVAAYEAERQLDPGDGGFCAAAGALWIYPTNCPVRDYQLDISRSALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQMEACFHVMGIPQSHMAEMTGSTQAVNRKEIWSSRRVLFLTPQVMVNDLTRGAVPATHVKCLVVDEAHKALGNYAYCQVVRELVKYTTHFRILALSATPGSDIKAVQQVITNLLIGKIELRSEESPDILPYSHERRVEKLVVPLGEELGAIQKTYIQILETFASSLIHRNVLMKRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFALCISLYHGYELLQQMGMRSLYFFLSGIMDGTKGMTRARNELSRNEDFMKLYTHLQSAFAPASTSDASAFQRGNKEKKFVYSHPKLKKLEEVILEHFKSWNAKATTEKKCHESRVMIFSSFRDSVEEIAEMLLQHRPVIRVMTFVGHASGKNTKGFTQKEQLQVVRQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRKRQGRIVVILAEGREERTYNQSQSNKKNIYKAISGNRQVLRLYQGSPRMVPDKINPELHKMYITHGVYEPEKARSVQRRPFSSRGGIKASKSNKDGLLSEEEFNLWSRLYRLGDSDQVKGVALPQSHFPSLQEDRVIQDPTTRIHQLSLSEWSLWQDRPLPTHQVDHSDRCHHFISIMKMIEGMRHEEGECSYELKIRPFLQMEDVCSKYHAPRNGYNNVASVASSAHQKSSFRPSVDAGGSLTVIESEEEHADTVKQRDSKWTKITSLREKPCRAGRKGQTCEHSEGEGEDGDAGSSDADGQSPAEADSQVDPPSGERMADVGGISILGAVTEEDNHPGTLQMECQVTNKSCARYSLDSGYSSFSDEKSVSSNLFLPLEEELFTDRAAEQFYNCRPMTEDVLANVERFLSRSPPSLSGLSDLVYDVTQGCEFDNASCSPYPEHEHSPRPVSPASHSAGNSQQNLESNSAKRISHPTEKYCLPGTTHNKVSDRPSFCESDSEGHNIKYQNSGSNSCAQIQADLENNFVDKNSHDDSEPPVLFTDEDESLLLFEDDFKNIEDGPEELNGASLPPFNSISQPLRVSGKTLTSEMPPVSHFLISDELLLDDDSEPEDQIVCGAKSWKCQEGVEDGQEELRTDGQTFDCSVDLFSVTFDLGFRCSSGSDDEMLAGASDRTRTLGAADVSGRHSDKEIKDAGGASGPLGRAISPIPTETAQWSPWAQNKEYASFHVASSSPVKQRVRSTPLSKSHASSKTGAHMLKTLDSTKEKAGGQGFKMALNPRLGHLGFSVEETKSSDQVFVHQSPRRTEVEHLTSESEDDVFLRKTKKPKRNVLKSPEDQKNNEVDSPIHAVKKPRVLRSELASSDDESENFGRTCPRLEHFKGRNRNIRKGSAAQKNRSQVKTMARRFLDDEAEVSGEDVDCVSADEEDESENEQDSSLLDFVNDRTQLSQAINDSEMRAIYMKSVRSPLMSTKYRMVREKRPNMNIFSQIPEQDENYLEDSFCVDEEESCKSQSSEEEISVDFNLTKDSFTDEDIRYKTRYAVKIKQMNKKQNYTRPRKKLSRIILPDDDSSEEENIPKDREHSVAGGHAAAEHTQQGQLWASGPSGSSVPPQVLSDPSWNQSSRQRLQVQPSITDAVPRTLNVKAQSHNKIKSASPPCTGVESRKEYGNHPVQLKADSQEHSDTSAAPCSTSLLHVAEGHTAPRHLQEGNRACILVDSREITTGLEVISSLRTVHGLQVEICPLNGCDYIVSSRMVVVRRSQSEMLSNTSKNKFIEQMQRLQSMFQRICVIVEKDREKAGDTSKKFRRTKCYDSLLTALVGAGIRILFSSGQEETADLLKELSLVEQRKNAGIHIPAVLNTSKLEALPFYLSIPGISYITALNMCHQFSSVKKMANSSPEEISTCAQVNHQKAEEIYKYIHYIFDMQMLPNDLNQERQKPDTCLTLGVAMKELS
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA. {ECO:0000250|UniProtKB:Q8IYD8}.
uniprot
proteins
mass_dalton
226018
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; hyperphosphorylated in response to genotoxic stress. {ECO:0000250|UniProtKB:Q8IYD8}.
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
protein_family
DEAH subfamily
uniprot
proteins
protein_family
FANCM sub-subfamily
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
2021
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8IYD8}.
uniprot
proteins