Mmp14
entrez
81707
canonical
uniprot
Q10739
canonical
ensembl
ENSRNOG00000010947
resolver
ensembl
ENSRNOG00055011907
resolver
ensembl
ENSRNOG00060027477
resolver
ensembl
ENSRNOG00065031768
resolver
ensp
ENSRNOP00000065434
resolver
ensp
ENSRNOP00055016353
resolver
ensp
ENSRNOP00060039863
resolver
ensp
ENSRNOP00065045061
resolver
enst
ENSRNOT00000075610
resolver
enst
ENSRNOT00055020294
resolver
enst
ENSRNOT00060047919
resolver
enst
ENSRNOT00065054795
resolver
genesymbol
Mmp14
resolver
genesymbol_syn
Mtmmp
resolver
uniprot
Q6IN06
resolver
uniprot_entry
MMP14_RAT
resolver
uniprot_sec
Q6IN06
resolver
amino_acid_sequence
MSPAPRPSRSLLLPLLTLGTTLASLGWAQSSNFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQRFYGLQVTGKADSDTMKAMRRPRCGVPDKFGTEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATFEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMILFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVQNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGSKSGSPTKMPPQPRTTSRPSVPDKPRNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEEFRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGSGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPKRLLYCQRSLLDKV
uniprot
proteins
ec_number
3.4.24.80
uniprot
proteins
function
FUNCTION: Endopeptidase that degrades various components of the extracellular matrix such as collagen (By similarity). Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis. Acts as a negative regulator of the GDF15-GFRAL aversive response by mediating cleavage and inactivation of GFRAL (By similarity). {ECO:0000250|UniProtKB:P50281, ECO:0000250|UniProtKB:P53690}.
uniprot
proteins
mass_dalton
66080
uniprot
proteins
post_translational_modification
PTM: The precursor is cleaved by a furin endopeptidase. {ECO:0000250|UniProtKB:P50281}.; PTM: Tyrosine phosphorylated by PKDCC/VLK. {ECO:0000250|UniProtKB:P50281}.
uniprot
proteins
protein_family
Peptidase M10A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7708715
uniprot
proteins
sequence_length
582
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P50281}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P50281}. Melanosome {ECO:0000250|UniProtKB:P50281}. Cytoplasm {ECO:0000250|UniProtKB:P50281}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm. {ECO:0000250|UniProtKB:P50281}.
uniprot
proteins
transmembrane_region
TRANSMEM 542..562; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins