Gpr18
entrez
110168
canonical
uniprot
Q8K1Z6
canonical
ensembl
ENSMUSG00000050350
resolver
ensp
ENSMUSP00000061410
resolver
enst
ENSMUST00000055475
resolver
genesymbol
Gpr18
resolver
uniprot
Q3T9N3
resolver
uniprot_entry
GPR18_MOUSE
resolver
uniprot_sec
Q3T9N3
resolver
amino_acid_sequence
MATLSNHNQLDLSNGSHPEEYKIAALVFYSCIFLIGLFVNVTALWVFSCTTKKRTTVTIYMMNVALLDLVFILSLPFRMFYYAKGEWPFGEYFCHILGALVVFYPSLALWLLAFISADRYMAIVQPKYAKELKNTGKAVLACGGVWVMTLTTTVPLLLLYEDPDKASSPATCLKISDITHLKAVNVLNFTRLIFFFLIPLFIMIGCYVVIIHSLLRGQTSKLKPKVKEKSIRIIMTLLLQVLVCFVPFHICFAVLMLQGQENSYSPWGAFTTFLMNLSTCLDVVLYYIVSKQFQARVISVMLYRNYLRSVRRKSVRSGSLRSLSNMNSEML
uniprot
proteins
function
FUNCTION: G protein-coupled receptor (GPCR) that plays a role in diverse physiological processes particularly within the immune and nervous systems. Becomes active when triggered by various endogenous ligands including endocannabinoid N-arachidonyl glycine (NAGly), delta-9-tetrahydrocannabinol or resolvin D2/RvD2 derived from the omega-3 fatty acid docosahexaenoic acid (DHA). Upon RvD2 binding, facilitates the resolution of inflammation, aiding in tissue repair and homeostasis (PubMed:26195725). Mechanistically, RvD2 ligation initiates Galphas protein coupling, activation of cAMP-PKA signaling pathway and phosphorylation of STAT3, leading to RvD2-stimulated macrophage phagocytosis. Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (By similarity). Activation by N-arachidonoyl glycine (NAGly) can also induce apoptosis in macrophages (PubMed:22266325). Plays a role in homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intestine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (PubMed:25348153, PubMed:26197390). Also participates in hypotensive responses, mediating reduction in intraocular and blood pressure (PubMed:27893106). {ECO:0000250|UniProtKB:Q14330, ECO:0000269|PubMed:22266325, ECO:0000269|PubMed:23461720, ECO:0000269|PubMed:25348153, ECO:0000269|PubMed:26195725, ECO:0000269|PubMed:26197390, ECO:0000269|PubMed:27893106}.
uniprot
proteins
mass_dalton
37691
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22266325
uniprot
proteins
pubmed
23104136
uniprot
proteins
pubmed
23461720
uniprot
proteins
pubmed
25348153
uniprot
proteins
pubmed
26195725
uniprot
proteins
pubmed
26197390
uniprot
proteins
pubmed
27893106
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23104136}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q14330}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 57..77; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 96..116; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 237..257; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins