GPR174
entrez
84636
canonical
uniprot
Q9BXC1
canonical
ensembl
ENSG00000147138
resolver
ensp
ENSP00000494310
resolver
ensp
ENSP00000542004
resolver
enst
ENST00000645147
resolver
enst
ENST00000871945
resolver
genesymbol
GPR174
resolver
hgnc
HGNC:30245
resolver
uniprot
Q2M3F7
resolver
uniprot_entry
GP174_HUMAN
resolver
uniprot_sec
Q2M3F7
resolver
amino_acid_sequence
MPANYTCTRPDGDNTDFRYFIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFHDCKQKYDLYISIAGWLIICLACVLFPLLRTSDDTSGNRTKCFVDLPTRNVNLAQSVVMMTIGELIGFVTPLLIVLYCTWKTVLSLQDKYPMAQDLGEKQKALKMILTCAGVFLICFAPYHFSFPLDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFSTNEFRRRLSRQDLHDSIQLHAKSFVSNHTASTMTPELC
uniprot
proteins
function
FUNCTION: G protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed:36823105). Plays a negative role in regulatory T-cell accumulation and homeostasis. Under inflammatory conditions where LysoPS production increases, contributes to the down-regulation of regulatory T-cell activity to favor effector response. Mediates the suppression of IL-2 production in activated T-lymphocytes leading to inhibition of growth, proliferation and differentiation of T-cells. Mechanistically, acts via G(s)-containing heterotrimeric G proteins to trigger elevated cyclic AMP levels and protein kinase A/PKA activity, which may in turn act to antagonize proximal TCR signaling. Plays an important role in the initial period of sepsis through the regulation of macrophage polarization and pro- and anti-inflammatory cytokine secretions. Upon testosterone treatment, acts as a receptor for CCL21 and subsequently triggers through G(q)-alpha and G(12)/G(13) proteins a calcium flux leading to chemotactic effects on activated B-cells. Signals via GNA13 and PKA to promote CD86 up-regulation by follicular B-cells. {ECO:0000250|UniProtKB:Q3U507, ECO:0000269|PubMed:36823105}.
uniprot
proteins
mass_dalton
38503
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="Y->A: Substantially reduced receptor activity."; /evidence="ECO:0000269|PubMed:36823105"; MUTAGEN 75; /note="R->A: Substantially reduced receptor activity."; /evidence="ECO:0000269|PubMed:36823105"; MUTAGEN 98; /note="K->A: Substantially reduced receptor activity."; /evidence="ECO:0000269|PubMed:36823105"; MUTAGEN 156; /note="R->A: Substantially reduced receptor activity."; /evidence="ECO:0000269|PubMed:36823105
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12044878
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
36823105
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 28..48; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 54..74; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 135..155; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 270..290; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins