RAB42
entrez
115273
canonical
uniprot
Q8N4Z0
canonical
ensembl
ENSG00000188060
resolver
ensp
ENSP00000362932
resolver
ensp
ENSP00000491546
resolver
genesymbol
RAB42
resolver
hgnc
HGNC:28702
resolver
uniprot
A0A1W2PQ57
resolver
uniprot
B2R5G2
resolver
uniprot_entry
RAB42_HUMAN
resolver
uniprot_sec
A0A1W2PQ57
resolver
uniprot_sec
B2R5G2
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:P62820}.
uniprot
proteins
amino_acid_sequence
MEAEGCRYQFRVALLGDAAVGKTSLLRSYVAGAPGAPEPEPEPEPTVGAECYRRALQLRAGPRVKLQLWDTAGHERFRCITRSFYRNVVGVLLVFDVTNRKSFEHIQDWHQEVMATQGPDKVIFLLVGHKSDLQSTRCVSAQEAEELAASLGMAFVETSVKNNCNVDLAFDTLADAIQQALQQGDIKLEEGWGGVRLIHKTQIPRSPSRKQHSGPCQC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). The physiological function of RAB42 remains undefined (Probable). {ECO:0000250|UniProtKB:P62820, ECO:0000305}.
uniprot
proteins
mass_dalton
24133
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P62820}; Lipid-anchor {ECO:0000250|UniProtKB:P62820}.
uniprot
proteins