Amigo1
entrez
229715
canonical
uniprot
Q80ZD8
canonical
ensembl
ENSMUSG00000050947
resolver
ensp
ENSMUSP00000061244
resolver
ensp
ENSMUSP00000102267
resolver
ensp
ENSMUSP00000102270
resolver
genesymbol
Amigo1
resolver
genesymbol_syn
Ali2
resolver
genesymbol_syn
Amigo
resolver
genesymbol_syn
Kiaa1163
resolver
uniprot
A2AE40
resolver
uniprot
Q69ZQ0
resolver
uniprot
Q8R5D4
resolver
uniprot
Q921U9
resolver
uniprot_entry
AMGO1_MOUSE
resolver
uniprot_sec
A2AE40
resolver
uniprot_sec
Q69ZQ0
resolver
uniprot_sec
Q8R5D4
resolver
uniprot_sec
Q921U9
resolver
amino_acid_sequence
MQPQRDLRGLWLLLLSVFLLLFEVARAGRSVVSCPANCLCASNILSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKKLPLTDLQKLPAWVKNGLYLHNNPLECDCKLYQLFSHWQYRQLSSVMDFQEDLYCMHSKKLHNIFSLDFFNCSEYKESAWEAHLGDTLTIRCDTKQQGMTKVWVSPSNEQVLSQGSNGSVSVRNGDLFFKKVQVEDGGVYTCYAMGETFNETLSVELKVYNFTLHGHHDTLNTAYTTLVGCILSVVLVLIYLYLTPCRCWCRGVEKPSSHQGDSLSSSMLSTTPNHDPMAGGDKDDGFDRRVAFLEPAGPGQGQNGKLKPGNTLPVPEATGKGQRRMSDPESVSSVFSDTPIVV
uniprot
proteins
function
FUNCTION: Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity). Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:22056818). {ECO:0000250|UniProtKB:Q80ZD7, ECO:0000269|PubMed:22056818}.
uniprot
proteins
mass_dalton
55343
uniprot
proteins
mutagenesis
MUTAGEN 348; /note="N->A: Prevents from leaving the ER."; /evidence="ECO:0000269|PubMed:21983541
uniprot
proteins
protein_family
AMIGO family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
12629050
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21983541
uniprot
proteins
pubmed
22056818
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21983541, ECO:0000269|PubMed:22056818}; Single-pass type I membrane protein {ECO:0000269|PubMed:21983541}. Perikaryon {ECO:0000269|PubMed:22056818}. Cell projection, dendrite {ECO:0000269|PubMed:22056818}. Note=Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal and cortical neurons (PubMed:22056818). Associated with axons of neuronal cells (By similarity). {ECO:0000250|UniProtKB:Q80ZD7, ECO:0000269|PubMed:22056818}.
uniprot
proteins
transmembrane_region
TRANSMEM 372..392; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins