Ensa
entrez
60334
canonical
uniprot
P60841
canonical
ensembl
ENSRNOG00000048617
resolver
ensembl
ENSRNOG00055031649
resolver
ensembl
ENSRNOG00060013225
resolver
ensembl
ENSRNOG00065023447
resolver
ensp
ENSRNOP00000063946
resolver
ensp
ENSRNOP00000083613
resolver
genesymbol
Ensa
resolver
uniprot
Q6PCU7
resolver
uniprot
Q9CQZ9
resolver
uniprot
Q9Z0G1
resolver
uniprot_entry
ENSA_RAT
resolver
uniprot_sec
Q6PCU7
resolver
uniprot_sec
Q9CQZ9
resolver
uniprot_sec
Q9Z0G1
resolver
amino_acid_sequence
MSQKQEEENPAEETGEEKQDTQEKEGILPEKAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGQKYFDSGDYNMAKAKMKNKQLPSAGADKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE
uniprot
proteins
function
FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
13335
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A. Phosphorylated by PKA (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Endosulfine family
uniprot
proteins
pubmed
11279279
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9653196
uniprot
proteins
sequence_length
121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11279279}.
uniprot
proteins