APBB1IP
entrez
54518
canonical
uniprot
Q7Z5R6
canonical
ensembl
ENSG00000077420
resolver
ensp
ENSP00000365411
resolver
ensp
ENSP00000542327
resolver
genesymbol
APBB1IP
resolver
genesymbol_syn
PREL1
resolver
genesymbol_syn
RARP1
resolver
genesymbol_syn
RIAM
resolver
hgnc
HGNC:17379
resolver
uniprot
Q8IWS8
resolver
uniprot
Q8IYL7
resolver
uniprot
Q8IZZ7
resolver
uniprot_entry
AB1IP_HUMAN
resolver
uniprot_sec
Q8IWS8
resolver
uniprot_sec
Q8IYL7
resolver
uniprot_sec
Q8IZZ7
resolver
amino_acid_sequence
MGESSEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPPRAEFNYSVGFKDLNESLNALEDQDLDALMADLVADISEAEQRTIQAQKESLQNQHHSASLQASIFSGAASLGYGTNVAATGISQYEDDLPPPPADPVLDLPLPPPPPEPLSQEEEEAQAKADKIKLALEKLKEAKVKKLVVKVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHENVVEVLSDWTRDTENKILFLEKEEKYAVFKNPQNFYLDNRGKKESKETNEKMNAKNKESLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFENVNIYYGTQHKMKYKAPTDYCFVLKHPQIQKESQYIKYLCCDDTRTLNQWVMGIRIAKYGKTLYDNYQRAVAKAGLASRWTNLGTVNAAAPAQPSTGPKTGTTQPNGQIPQATHSVSAVLQEAQRHAETSKDKKPALGNHHDPAVPRAPHAPKSSLPPPPPVRRSSDTSGSPATPLKAKGTGGGGLPAPPDDFLPPPPPPPPLDDPELPPPPPDFMEPPPDFVPPPPPSYAGIAGSELPPPPPPPPAPAPAPVPDSARPPPAVAKRPPVPPKRQENPGHPGGAGGGEQDFMSDLMKALQKKRGNVS
uniprot
proteins
function
FUNCTION: Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}.
uniprot
proteins
mass_dalton
73183
uniprot
proteins
protein_family
MRL family
uniprot
proteins
pubmed
14530287
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15469846
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15642358
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23389036
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
666
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity). {ECO:0000250}.
uniprot
proteins