SFTPB
entrez
6439
canonical
uniprot
P07988
canonical
ensembl
ENSG00000168878
resolver
ensp
ENSP00000377409
resolver
ensp
ENSP00000386346
resolver
ensp
ENSP00000415347
resolver
ensp
ENSP00000428719
resolver
ensp
ENSP00000530729
resolver
ensp
ENSP00000530731
resolver
ensp
ENSP00000530732
resolver
ensp
ENSP00000530733
resolver
ensp
ENSP00000530741
resolver
ensp
ENSP00000530742
resolver
ensp
ENSP00000530758
resolver
ensp
ENSP00000530759
resolver
ensp
ENSP00000530764
resolver
ensp
ENSP00000530767
resolver
ensp
ENSP00000530769
resolver
ensp
ENSP00000530779
resolver
ensp
ENSP00000530787
resolver
ensp
ENSP00000624940
resolver
ensp
ENSP00000624941
resolver
ensp
ENSP00000624943
resolver
ensp
ENSP00000624945
resolver
ensp
ENSP00000625003
resolver
ensp
ENSP00000625005
resolver
ensp
ENSP00000646294
resolver
ensp
ENSP00000686493
resolver
enst
ENST00000393822
resolver
enst
ENST00000409383
resolver
enst
ENST00000519937
resolver
enst
ENST00000860670
resolver
enst
ENST00000860672
resolver
enst
ENST00000860673
resolver
enst
ENST00000860674
resolver
enst
ENST00000860682
resolver
enst
ENST00000860683
resolver
enst
ENST00000860699
resolver
enst
ENST00000860705
resolver
enst
ENST00000860708
resolver
enst
ENST00000860710
resolver
enst
ENST00000860720
resolver
enst
ENST00000860728
resolver
enst
ENST00000954881
resolver
enst
ENST00000954882
resolver
enst
ENST00000954884
resolver
enst
ENST00000954886
resolver
enst
ENST00000954944
resolver
enst
ENST00000954946
resolver
genesymbol
SFTPB
resolver
genesymbol_syn
SFTP3
resolver
hgnc
HGNC:10801
resolver
uniprot
Q96R04
resolver
uniprot_entry
PSPB_HUMAN
resolver
uniprot_sec
Q96R04
resolver
amino_acid_sequence
MAESHLLQWLLLLLPTLCGPGTAAWTTSSLACAQGPEFWCQSLEQALQCRALGHCLQEVWGHVGADDLCQECEDIVHILNKMAKEAIFQDTMRKFLEQECNVLPLKLLMPQCNQVLDDYFPLVIDYFQNQTDSNGICMHLGLCKSRQPEPEQEPGMSDPLPKPLRDPLPDPLLDKLVLPVLPGALQARPGPHTQDLSEQQFPIPLPYCWLCRALIKRIQAMIPKGALAVAVAQVCRVVPLVAGGICQCLAERYSVILLDTLLGRMLPQLVCRLVLRCSMDDSAGPRSPTGEWLPRDSECHLCMSVTTQAGNSSEQAIPQAMLQACVGSWLDREKCKQFVEQHTPQLLTLVPRGWDAHTTCQALGVCGTMSSPLQCIHSPDL
uniprot
proteins
disease_involvement
DISEASE: Pulmonary surfactant metabolism dysfunction 1 (SMDP1) [MIM:265120]: A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. {ECO:0000269|PubMed:7491219}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Respiratory distress syndrome in premature infants (RDS) [MIM:267450]: A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. {ECO:0000269|PubMed:11063734}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry. A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.
uniprot
proteins
function
FUNCTION: Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
uniprot
proteins
mass_dalton
42117
uniprot
proteins
pubmed
10798379
uniprot
proteins
pubmed
11063734
uniprot
proteins
pubmed
11076040
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1568474
uniprot
proteins
pubmed
17845058
uniprot
proteins
pubmed
2924687
uniprot
proteins
pubmed
3035561
uniprot
proteins
pubmed
3343343
uniprot
proteins
pubmed
3597440
uniprot
proteins
pubmed
7491219
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, surface film.
uniprot
proteins