Cdc14a
entrez
229776
canonical
uniprot
Q6GQT0
canonical
ensembl
ENSMUSG00000033502
resolver
ensp
ENSMUSP00000087950
resolver
ensp
ENSMUSP00000102100
resolver
ensp
ENSMUSP00000159189
resolver
ensp
ENSMUSP00000292500
resolver
ensp
ENSMUSP00000292508
resolver
enst
ENSMUST00000239145
resolver
genesymbol
Cdc14a
resolver
uniprot
A0A5F8MPZ4
resolver
uniprot
Q8BZ66
resolver
uniprot_entry
A0A5F8MPZ4_MOUSE
resolver
uniprot_entry
CC14A_MOUSE
resolver
uniprot_sec
Q8BZ66
resolver
amino_acid_sequence
MAAESGELIGACEFMKDRLYFATLRNRPKSTINIHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKKLKSYSLSRKKIVHYTSFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTVLDCLQGIRKGLQHGFFDFETFDAEEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKNNVTTIVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLKEKQASLWVQGDIFRSKLKNRPSSEGSITKIISTLDDMSIGANLSKLQSTERIGENNFEDEDMEIKNNVTQGDKLRALKSQRHPRSSPSCAFRSDDMKGHQRAMAQTFRLSSSPQPTMSTMKTSKVCLSPSVTAKKISRGSLSSGANIRSFSINSRLASSLGNLNAGTEEPETKKTTSLTKAAFIASPFTSFLNGSTQTPGRNYPELNNNQYTRSSNSNSSSSSSGLGGNLNSSPVPQSAKPEEHTTILRPSFPGSLSSSSVRFLSRSIPSLQSEYVHY
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis (By similarity). Required for normal hearing (PubMed:29293958). {ECO:0000250|UniProtKB:Q9UNH5, ECO:0000269|PubMed:29293958}.
uniprot
proteins
mass_dalton
67634
uniprot
proteins
mutagenesis
MUTAGEN 278; /note="C->S: Mutant mice are deaf, show fusion of stereocilia and degeneration of hair cells, and have low sperm counts."; /evidence="ECO:0000269|PubMed:29293958
uniprot
proteins
protein_family
Non-receptor class CDC14 subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
27259055
uniprot
proteins
pubmed
29293958
uniprot
proteins
sequence_length
603
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UNH5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9UNH5}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9UNH5}. Cell projection, kinocilium {ECO:0000269|PubMed:27259055, ECO:0000269|PubMed:29293958}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9UNH5}. Cell projection, stereocilium {ECO:0000269|PubMed:29293958}. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the mitotic spindle pole and at the central spindle (By similarity). Present along both the transient kinocilia of developing cochlear hair cells and the persistent kinocilia of vestibular hair cells (PubMed:27259055). {ECO:0000250|UniProtKB:Q9UNH5, ECO:0000269|PubMed:27259055}.
uniprot
proteins