Mcub
entrez
66815
canonical
uniprot
Q810S1
canonical
ensembl
ENSMUSG00000027994
resolver
ensp
ENSMUSP00000029624
resolver
ensp
ENSMUSP00000118170
resolver
ensp
ENSMUSP00000320909
resolver
ensp
ENSMUSP00000320914
resolver
enst
ENSMUST00000153506
resolver
genesymbol
Mcub
resolver
genesymbol_syn
Ccdc109b
resolver
uniprot
D6RIL8
resolver
uniprot
Q3U4A9
resolver
uniprot
Q9CSE7
resolver
uniprot
Q9D345
resolver
uniprot_entry
D6RIL8_MOUSE
resolver
uniprot_entry
MCUB_MOUSE
resolver
uniprot_sec
Q3U4A9
resolver
uniprot_sec
Q9CSE7
resolver
uniprot_sec
Q9D345
resolver
amino_acid_sequence
MPGALSGRRMLPSGLCLGRWQLLRTIRARGRGDPRELPSTPQVLCMKLYGNPKYHQALHYGTVEPQDEITVTYKHGLPLVTLTLPSRKERCQFVVKPMLSTVGSFLQDLQNEDKGIKTAAIITADGSEIPASTLMDTLLMTDFKLIINKLRYDIRCHKKEEPSGEHMTELENTKSLVHRLFTILHLEEIQKRRERHLMAKIDHLQEQLRPLEQVKAAIEARSEANTSGLLWAGLALLSVQGGALAWLTWWVYSWDIMEPVTFFLSFANSIVFFAYFIITRQNYTYSSLRSRQFLQFFHKKSQRRCFDVEQYNKLKEDLAEATESLESVRRSLRLRIQGEEASEKN
uniprot
proteins
function
FUNCTION: Negative regulator of the mitochondrial calcium uniporter (MCU), a channel that mediates calcium uptake into the mitochondrial matrix (PubMed:23900286, PubMed:31533452, PubMed:37976157). MCUB is required to limit mitochondrial calcium overload during stress (PubMed:31533452, PubMed:37976157). Acts as a dominant-negative regulator that displaces MCU from the functional uniplex complex and thereby decreases the association of calcium sensors MICU1 and MICU2, preventing channel gating (PubMed:31533452). Mitochondrial calcium homeostasis plays key roles in mitochondrial metabolism (PubMed:23900286, PubMed:31533452). Acts as an important regulator of mitochondrial metabolism in response to stress in muscle cells: induced in response to fasting, leading to restrict mitochondrial calcium uptake, resulting in reprogramming of mitochondria toward fatty acid oxidation preference (PubMed:37976157). Acts as a regulator of macrophage polarization during skeletal muscle regeneration: inhibition of mitochondrial calcium uptake drives differentiation of macrophages with anti-inflammatory profile, promoting the differentiation and fusion of satellite cells (PubMed:34726954). {ECO:0000269|PubMed:23900286, ECO:0000269|PubMed:31533452, ECO:0000269|PubMed:34726954, ECO:0000269|PubMed:37976157}.
uniprot
proteins
mass_dalton
39799
uniprot
proteins
protein_family
MCU (TC 1.A.77) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23900286
uniprot
proteins
pubmed
31533452
uniprot
proteins
pubmed
34726954
uniprot
proteins
pubmed
37976157
uniprot
proteins
sequence_length
345
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:23900286}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 229..249; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 259..279; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins