Emc10
entrez
292878
canonical
uniprot
Q6AYH6
canonical
ensembl
ENSRNOG00000019532
resolver
ensp
ENSRNOP00000026445
resolver
ensp
ENSRNOP00000092592
resolver
enst
ENSRNOT00000026445
resolver
genesymbol
Emc10
resolver
genesymbol_syn
Inm02
resolver
uniprot
A0A8L2QF76
resolver
uniprot_entry
A0A8L2QF76_RAT
resolver
uniprot_entry
EMC10_RAT
resolver
amino_acid_sequence
MVAAGAGVTQLLVLLLMVAAVPSRARGSGCRVGAAARGVGADGHEAEGCGTVALLLEHSFEIGDGANFQKRGSLLWNQQDGTLSATQRQLSEEERGRLRDVAAVNGLYRVRVPRRPGTLDGSEAGGHVSSFVPACSLVESHLSDQLTLHVDVAGNVVGLSVVVYPGGCRGSEVEDEDLELFNTSVHLRPPGTAPGPETAAFIERLEMEQAQKAKNPQEQKSFFAKYWMYIIPVVLFLMMSGAPDAGGQGGGGGGGSSR
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways. {ECO:0000250|UniProtKB:Q5UCC4}.
uniprot
proteins
mass_dalton
26968
uniprot
proteins
protein_family
EMC10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19570817
uniprot
proteins
pubmed
24090084
uniprot
proteins
sequence_length
258
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5UCC4}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q5UCC4}.
uniprot
proteins
transmembrane_region
TRANSMEM 222..242; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins