NME7
entrez
29922
canonical
uniprot
Q9Y5B8
canonical
ensembl
ENSG00000143156
resolver
ensp
ENSP00000356785
resolver
ensp
ENSP00000433341
resolver
genesymbol
NME7
resolver
hgnc
HGNC:20461
resolver
uniprot
A8K3T6
resolver
uniprot
A8MY09
resolver
uniprot
B3KSW9
resolver
uniprot
Q5TGZ4
resolver
uniprot_entry
NDK7_HUMAN
resolver
uniprot_sec
A8K3T6
resolver
uniprot_sec
A8MY09
resolver
uniprot_sec
B3KSW9
resolver
uniprot_sec
Q5TGZ4
resolver
amino_acid_sequence
MNHSERFVFIAEWYDPNASLLRRYELLFYPGDGSVEMHDVKNHRTFLKRTKYDNLHLEDLFIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAISKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVTEMYSGPCVAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFKILDN
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
3.1.11.-
uniprot
proteins
function
FUNCTION: Possesses an intrinsic kinase activity (PubMed:24807905, PubMed:34764205). Phosphorylates GSK3B at 'Ser-9', leading to the activation of Wnt/beta-catenin signaling (PubMed:34764205). Additionally, exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing (PubMed:16313181). In vitro, does not seem to have nucleoside diphosphate kinase activity (PubMed:16313181, PubMed:24807905). Functional component of the gamma-tubulin ring complex, implicated in the regulation of its microtubule-nucleating activity in centrosomes, in a kinase activity-dependent manner (PubMed:24807905). May maintain primary cilium assembly and ciliary microtubule stability (PubMed:39824631). Part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, required for motile cilia beating (PubMed:36191189). {ECO:0000269|PubMed:16313181, ECO:0000269|PubMed:24807905, ECO:0000269|PubMed:34764205, ECO:0000269|PubMed:36191189, ECO:0000269|PubMed:39824631}.
uniprot
proteins
mass_dalton
42492
uniprot
proteins
mutagenesis
MUTAGEN 173; /note="K->A: Abolishes NME7 autophosphorylation."; /evidence="ECO:0000269|PubMed:24807905"; MUTAGEN 206; /note="H->A: Decrease protein kinase activity."; /evidence="ECO:0000269|PubMed:34764205"; MUTAGEN 206; /note="H->F: Abolishes NME7 autophosphorylation."; /evidence="ECO:0000269|PubMed:24807905"; MUTAGEN 322; /note="R->A: Does not affect NME7 autophosphorylation. Reduces interaction with the gamma-tubulin ring complex."; /evidence="ECO:0000269|PubMed:24807905"; MUTAGEN 322; /note="R->E: Abolishes interaction with the gamma-tubulin ring complex."; /evidence="ECO:0000269|PubMed:24807905"; MUTAGEN 355; /note="H->F: Does not affect NME7 autophosphorylation."; /evidence="ECO:0000269|PubMed:24807905
uniprot
proteins
post_translational_modification
PTM: Undergoes autophosphorylation. {ECO:0000269|PubMed:24807905}.
uniprot
proteins
protein_family
NDK family
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16313181
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24807905
uniprot
proteins
pubmed
34764205
uniprot
proteins
pubmed
36191189
uniprot
proteins
pubmed
37258679
uniprot
proteins
pubmed
38538594
uniprot
proteins
pubmed
39824631
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24807905, ECO:0000269|PubMed:38538594, ECO:0000269|PubMed:39824631}. Nucleus {ECO:0000269|PubMed:24807905, ECO:0000305|PubMed:16313181}. Cytoplasm {ECO:0000269|PubMed:24807905}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:24807905}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189, ECO:0000269|PubMed:37258679}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q5E9Y9}. Cell projection, cilium {ECO:0000269|PubMed:38538594, ECO:0000269|PubMed:39824631}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:39824631}. Note=Localizes to centrosomes through its assembly into gamma-tubulin ring complex. The centrosomal content of NME7 varies during the cell cycle, being highest in mitosis and lowest in early G1 (PubMed:24807905). Localizes at the cilium basal body during cilium assembly (By similarity). {ECO:0000250|UniProtKB:Q9QXL8, ECO:0000269|PubMed:24807905}.
uniprot
proteins