Atg14
entrez
100504663
canonical
uniprot
Q8CDJ3
canonical
ensembl
ENSMUSG00000037526
resolver
ensp
ENSMUSP00000039047
resolver
ensp
ENSMUSP00000153718
resolver
enst
ENSMUST00000042988
resolver
enst
ENSMUST00000226299
resolver
genesymbol
Atg14
resolver
genesymbol_syn
Atg14L
resolver
genesymbol_syn
D14Ertd436e
resolver
genesymbol_syn
Kiaa0831
resolver
uniprot
Q69ZY1
resolver
uniprot
Q6PFY6
resolver
uniprot
Q8C6N0
resolver
uniprot
Q8R3M3
resolver
uniprot_entry
BAKOR_MOUSE
resolver
uniprot_sec
Q69ZY1
resolver
uniprot_sec
Q6PFY6
resolver
uniprot_sec
Q8C6N0
resolver
uniprot_sec
Q8R3M3
resolver
amino_acid_sequence
MASPSGKGSWTPEAPGFGPRALARDLVDSVDDAEGLYVAVERCPLCNTTRRRLTCAKCVQSGDFVYFDGRDRERFIDKKERLSQLKNKQEEFQKEVLKAMEGKRLTDQLRWKIMSCKMRIEQLKQTICKGNEEMKKNSEGLLKNKEKNQKLYSRAQRHQEKKEKIQRHNRKLGDLVEKKTIDLKSHYERLARLRRSHILELTSIIFPIDEVKTSGRDPADVSSETDSAMTSSMVSKLAEARRTTYLSGRWVCDDHNGDTSISITGPWISLPNNGDYSAYYNWVEEKKTTQGPDMEHNNPAYTISAALGYATQLVNIVSHILDINLPKKLCNSEFCGENLSKQKLTRAVRKLNANILYLCSSQHVNLDQLQPLHTLRNLMHLVSPRSEHLGRSGPFEVRADLEESMEFVDPGVAGESDASGDERVSDEETDLGTDWENLPSPRFCDIPSQPVEVSQSQSTQVSPPIASSSAGGMISSAAASVTSWFKAYTGHR
uniprot
proteins
function
FUNCTION: Required for both basal and inducible autophagy (PubMed:19270693, PubMed:19270696). Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (By similarity). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270693, PubMed:19270696). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (By similarity). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (By similarity). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation of PIK3C3 by AMPK (PubMed:23332761). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (By similarity). Modulates the hepatic lipid metabolism (PubMed:22992773). {ECO:0000250|UniProtKB:Q6ZNE5, ECO:0000269|PubMed:19270693, ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:22992773, ECO:0000269|PubMed:23332761}.
uniprot
proteins
mass_dalton
55388
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated via 'Lys-6', 'Lys-11' and 'Lys-63'-linked polyubiquitin chains on multiple lysines by MARCHF7, leading to ATG14 aggregation and loss of interaction with STX17. {ECO:0000250|UniProtKB:Q6ZNE5}.
uniprot
proteins
protein_family
ATG14 family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18843052
uniprot
proteins
pubmed
19270693
uniprot
proteins
pubmed
19270696
uniprot
proteins
pubmed
20639694
uniprot
proteins
pubmed
21059846
uniprot
proteins
pubmed
21518905
uniprot
proteins
pubmed
22745922
uniprot
proteins
pubmed
22863730
uniprot
proteins
pubmed
22992773
uniprot
proteins
pubmed
23332761
uniprot
proteins
pubmed
24089209
uniprot
proteins
pubmed
24849286
uniprot
proteins
pubmed
34428398
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20639694}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20639694}; Peripheral membrane protein {ECO:0000305}. Preautophagosomal structure membrane {ECO:0000269|PubMed:19270693, ECO:0000269|PubMed:20639694, ECO:0000269|PubMed:22863730}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q6ZNE5}; Peripheral membrane protein {ECO:0000305}. Note=Cytosolic under nutrient-rich conditions (PubMed:20639694). Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes (PubMed:20639694). Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (PubMed:21518905). Also localizes to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (PubMed:24089209). {ECO:0000269|PubMed:20639694, ECO:0000269|PubMed:21518905, ECO:0000269|PubMed:24089209}.
uniprot
proteins