Stra6
entrez
363071
canonical
uniprot
Q4QR83
canonical
ensembl
ENSRNOG00000008312
resolver
ensembl
ENSRNOG00055028268
resolver
ensembl
ENSRNOG00060022330
resolver
ensembl
ENSRNOG00065016601
resolver
ensp
ENSRNOP00000011074
resolver
ensp
ENSRNOP00055040252
resolver
ensp
ENSRNOP00060031992
resolver
ensp
ENSRNOP00065021785
resolver
enst
ENSRNOT00000011074
resolver
enst
ENSRNOT00055048943
resolver
enst
ENSRNOT00060038739
resolver
enst
ENSRNOT00065027664
resolver
genesymbol
Stra6
resolver
uniprot_entry
STRA6_RAT
resolver
amino_acid_sequence
MESQASENGSQTSSGVTDDYSSWYIEEPLGAEEVQPEGVNPLCQPTVPPALHHACLASLSLLALLLLALLVRRRRLWPHCAHCRPGLPSPVDFLAGNRSWTVPTAVFVALFSNLCLLLPDENPLPFLNRTAASSPDGEPETSRGPWKLLALLYYPALYYPLAACATAGHRAAYLLGTVLSWVHVSVQVWQRAECPQDPKIYKHYSLLASLPLLLSLGFLSLWYPVQVVQSIRHRTGAGSQGLQTSYSEKYLRALLCPKKLDSCSHPASKRSLLSRAWAFSQHSIYTPEPGFCLPLKLVISATLTGTATYQVALLLLVSVVPTVQKVRAGITTDVSYLLAGFGIVLSEDRQEVVELVKHHLWAVEACYISALVLSCSLTFLLLIRSLRTHRANLKALHRGAALDLGPPLQSTHPSRQAIVCWMSFSAYQTAFSCLGLLVQQVIFFLGTTILAFLVFVPLLHGRNLLLLRSLESTWPFWLTLVLAVILQNIAANWVFLESHHGYPELTNRRMLCVATFLLFPINMLVGAIMAIWRVLLSSLYNTVHLGQMDLSLLPQRAASLDPGYHTYRNFLRIEASQSHPGVIAFCALLLHVPSPQPQPPLAPQDSLRPAAEEEGMQLLQTKDLMAKGAGPKGSRSRARWGLAYTLLHNPSLQAFRKAALTSAKANGTQP
uniprot
proteins
function
FUNCTION: Functions as a retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency. Does not transport retinoic acid. {ECO:0000250|UniProtKB:Q9BX79}.
uniprot
proteins
mass_dalton
73763
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues in response to RBP4 binding. Phosphorylation requires the presence of LRAT, suggesting it may be triggered by the uptake of retinol that is then metabolized within the cell to retinoids that function as signaling molecules. {ECO:0000250|UniProtKB:Q9BX79}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
670
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q0V8E7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q0V8E7}. Note=In the retinal pigment epithelium localizes to the basolateral membrane. {ECO:0000250|UniProtKB:Q0V8E7}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..71; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F1RAX4"; TRANSMEM 99..119; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F1RAX4"; TRANSMEM 145..165; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F1RAX4"; TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F1RAX4"; TRANSMEM 206..226; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F1RAX4"; TRANSMEM 297..317; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F1RAX4"; TRANSMEM 369..389; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F1RAX4"; TRANSMEM 424..444; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F1RAX4"; TRANSMEM 475..495; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F1RAX4
uniprot
proteins