TMEM98
entrez
26022
canonical
uniprot
Q9Y2Y6
canonical
ensembl
ENSG00000006042
resolver
ensp
ENSP00000378138
resolver
ensp
ENSP00000406394
resolver
ensp
ENSP00000463245
resolver
ensp
ENSP00000521295
resolver
ensp
ENSP00000521296
resolver
ensp
ENSP00000521297
resolver
ensp
ENSP00000521298
resolver
ensp
ENSP00000521299
resolver
ensp
ENSP00000521301
resolver
ensp
ENSP00000591852
resolver
ensp
ENSP00000591853
resolver
ensp
ENSP00000591855
resolver
ensp
ENSP00000630374
resolver
ensp
ENSP00000630375
resolver
ensp
ENSP00000630377
resolver
ensp
ENSP00000630378
resolver
ensp
ENSP00000630379
resolver
enst
ENST00000394642
resolver
enst
ENST00000579849
resolver
enst
ENST00000851236
resolver
enst
ENST00000851237
resolver
enst
ENST00000851238
resolver
enst
ENST00000851239
resolver
enst
ENST00000851240
resolver
enst
ENST00000851242
resolver
enst
ENST00000921793
resolver
enst
ENST00000921794
resolver
enst
ENST00000921796
resolver
enst
ENST00000960315
resolver
enst
ENST00000960316
resolver
enst
ENST00000960318
resolver
enst
ENST00000960319
resolver
enst
ENST00000960320
resolver
genesymbol
TMEM98
resolver
hgnc
HGNC:24529
resolver
uniprot
E1P631
resolver
uniprot
Q9UFK2
resolver
uniprot_entry
TMM98_HUMAN
resolver
uniprot_sec
E1P631
resolver
uniprot_sec
Q9UFK2
resolver
amino_acid_sequence
METVVIVAIGVLATIFLASFAALVLVCRQRYCRPRDLLQRYDSKPIVDLIGAMETQSEPSELELDDVVITNPHIEAILENEDWIEDASGLMSHCIAILKICHTLTEKLVAMTMGSGAKMKTSASVSDIIVVAKRISPRVDDVVKSMYPPLDPKLLDARTTALLLSVSHLVLVTRNACHLTGGLDWIDQSLSAAEEHLEVLREAALASEPDKGLPGPEGFLQEQSAI
uniprot
proteins
disease_involvement
DISEASE: Nanophthalmos 4 (NNO4) [MIM:615972]: A form of nanophthalmos, a disorder of eye development characterized by extreme hyperopia and small functional eyes. The cornea and lens are normal in size and shape. Hyperopia occurs because insufficient growth along the visual axis places these lensing components too close to the retina. Nanophthalmic eyes show considerable thickening of both the choroidal vascular bed and scleral coat, which provide nutritive and structural support for the retina. NNO4 inheritance is autosomal dominant. {ECO:0000269|PubMed:24852644, ECO:0000269|PubMed:26392740}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1). {ECO:0000250|UniProtKB:Q91X86}.
uniprot
proteins
mass_dalton
24611
uniprot
proteins
protein_family
TMEM98 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24852644
uniprot
proteins
pubmed
25946230
uniprot
proteins
pubmed
26392740
uniprot
proteins
pubmed
31048900
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25946230}; Single-pass type II membrane protein {ECO:0000269|PubMed:25946230}. Secreted {ECO:0000269|PubMed:25946230}. Secreted, extracellular exosome {ECO:0000269|PubMed:25946230}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q91X86}; Single-pass type II membrane protein {ECO:0000269|PubMed:25946230}. Note=Secreted by exosomes through a non-classical pathway. {ECO:0000269|PubMed:25946230}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins