Asgr1
entrez
24210
canonical
uniprot
P02706
canonical
ensembl
ENSRNOG00000018693
resolver
ensembl
ENSRNOG00055032882
resolver
ensembl
ENSRNOG00060030352
resolver
ensembl
ENSRNOG00065027557
resolver
ensp
ENSRNOP00000025254
resolver
ensp
ENSRNOP00055046997
resolver
ensp
ENSRNOP00060043859
resolver
ensp
ENSRNOP00065039000
resolver
enst
ENSRNOT00000025254
resolver
enst
ENSRNOT00055056898
resolver
enst
ENSRNOT00060052761
resolver
enst
ENSRNOT00065047528
resolver
genesymbol
Asgr1
resolver
genesymbol_syn
Asgr-1
resolver
uniprot_entry
ASGR1_RAT
resolver
amino_acid_sequence
MTKDYQDFQHLDNENDHHQLQRGPPPAPRLLQRLCSGFRLFLLSLGLSILLLVVVCVITSQNSQLREDLRVLRQNFSNFTVSTEDQVKALTTQGERVGRKMKLVESQLEKHQEDLREDHSRLLLHVKQLVSDVRSLSCQMAALRGNGSERICCPINWVEYEGSCYWFSSSVKPWTEADKYCQLENAHLVVVTSWEEQRFVQQHMGPLNTWIGLTDQNGPWKWVDGTDYETGFKNWRPGQPDDWYGHGLGGGEDCAHFTTDGHWNDDVCRRPYRWVCETELGKAN
uniprot
proteins
function
FUNCTION: Transmembrane protein predominantly expressed on hepatocytes that plays a key role in endocytosis of plasma glycoproteins that lack terminal sialic acid residues. Specifically recognizes terminal galactose and N-acetylgalactosamine residues, facilitating the clearance of desialylated glycoproteins from circulation. Plays thereby a role in a variety of physiological processes, such as removal of desialylated platelets, elimination of activated lymphocytes and maintenance of serum glycoprotein homeostasis. Plays a role in the removal of desialylated platelets by activating a feedback loop regulating thrombopoietin (TPO) expression via the JAK2-STAT3 signaling pathway. Contributes also to recognition and elimination of activated lymphocytes by hepatocytes that can act as cytotoxic effectors (By similarity). May also play a physiological role in the regulatory network of lipid homeostasis (By similarity). Upon ligand binding, the receptor-ligand complex is internalized and trafficked to a sorting organelle, where dissociation occurs. The receptor is then recycled back to the cell surface (By similarity). {ECO:0000250|UniProtKB:P07306, ECO:0000250|UniProtKB:P34927}.
uniprot
proteins
mass_dalton
32849
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on a cytoplasmic Ser residue. {ECO:0000250|UniProtKB:P07306}.; PTM: Palmitoylated at Cys-35. Palmitoylation is essential for coated pit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes. {ECO:0000250|UniProtKB:P07306}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2945599
uniprot
proteins
pubmed
2995379
uniprot
proteins
pubmed
6095287
uniprot
proteins
pubmed
8943311
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins