Tnfsf18
entrez
240873
canonical
uniprot
Q7TS55
canonical
ensembl
ENSMUSG00000066755
resolver
ensp
ENSMUSP00000083251
resolver
enst
ENSMUST00000086084
resolver
genesymbol
Tnfsf18
resolver
genesymbol_syn
Gitrl
resolver
uniprot
Q7TNY2
resolver
uniprot
Q80YG2
resolver
uniprot_entry
TNF18_MOUSE
resolver
uniprot_sec
Q7TNY2
resolver
uniprot_sec
Q80YG2
resolver
amino_acid_sequence
MEEMPLRESSPQRAERCKKSWLLCIVALLLMLLCSLGTLIYTSLKPTAIESCMVKFELSSSKWHMTSPKPHCVNTTSDGKLKILQSGTYLIYGQVIPVDKKYIKDNAPFVVQIYKKNDVLQTLMNDFQILPIGGVYELHAGDNIYLKFNSKDHIQKTNTYWGIILMPDLPFIS
uniprot
proteins
function
FUNCTION: Cytokine that binds to TNFRSF18/AITR/GITR (PubMed:14521928, PubMed:14647196). Regulates T-cell responses (PubMed:14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed:14608036, PubMed:15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed:14521928, PubMed:14647196, PubMed:18178614). Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed:24107315). {ECO:0000250|UniProtKB:Q9UNG2, ECO:0000269|PubMed:14521928, ECO:0000269|PubMed:14608036, ECO:0000269|PubMed:14647196, ECO:0000269|PubMed:15128759, ECO:0000269|PubMed:18178614, ECO:0000269|PubMed:23892569, ECO:0000269|PubMed:24107315}.
uniprot
proteins
mass_dalton
19732
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:19390148}.
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
14521928
uniprot
proteins
pubmed
14608036
uniprot
proteins
pubmed
14647196
uniprot
proteins
pubmed
15128759
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18178614
uniprot
proteins
pubmed
18182486
uniprot
proteins
pubmed
19390148
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23892569
uniprot
proteins
pubmed
24107315
uniprot
proteins
sequence_length
173
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14521928, ECO:0000269|PubMed:14608036}; Single-pass type II membrane protein {ECO:0000269|PubMed:14521928, ECO:0000269|PubMed:14608036}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins