Hdgfl2
entrez
15193
canonical
uniprot
Q3UMU9
canonical
ensembl
ENSMUSG00000002833
resolver
ensp
ENSMUSP00000002911
resolver
ensp
ENSMUSP00000152948
resolver
ensp
ENSMUSP00000153249
resolver
ensp
ENSMUSP00000190007
resolver
ensp
ENSMUSP00000190008
resolver
genesymbol
Hdgfl2
resolver
genesymbol_syn
Hdgfrp2
resolver
uniprot
D6CHX5
resolver
uniprot
O35540
resolver
uniprot
Q3UIH6
resolver
uniprot
Q99L92
resolver
uniprot_entry
HDGR2_MOUSE
resolver
uniprot_sec
D6CHX5
resolver
uniprot_sec
O35540
resolver
uniprot_sec
Q3UIH6
resolver
uniprot_sec
Q99L92
resolver
amino_acid_sequence
MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEADLGCGSDVDKDKESRRVMTVTAVTTTATSDRMESDSDSDKSSDHSGLKRKTPVLKVSVSKRARRASSDLDQASVSPSEEDSESPSESEKTSDQDFTPEKKTAARPPRRGPLGGRKKKKVPSASDSDSKADSDGAKEEPVVTAQPSPSSSSSSSSSSSSDSDVSVKKPPRGRKPAEKPPPKPRGRRPKPERPPSTSSSDSDSDSGEVDRISEWKRRDEERRRELEARRRREQEEELRRLREQEREEKERRKERAERGGSSGEELEDEEPVKKRSRKARGRGTPSSSDSEPEGELGKEGKKLAKKSQLPGSESARKPGQKEKRGRPDEKPRARPVKVERTRKRSEGLSLERKGEKKKEPSVEERLQKLHSEIKFALKVDNPDVRKCLSALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMAKAAEVYTRLKSRVLGPKVEALQKVNKAGAEKERADNEKLEEQPGEQAPRELAEDEPSTDRSAPVNGEATSQKGENMEDRAQEDGQDSEDGPRGGSSEELHDSPRDNSDPAKPGNERQDHERTRLASESANDDNEDS
uniprot
proteins
function
FUNCTION: Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (By similarity). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (By similarity). Involved in cellular growth control, through the regulation of cyclin D1 expression (By similarity). Associates with chromatin (PubMed:22212508). {ECO:0000250|UniProtKB:Q7Z4V5, ECO:0000269|PubMed:22212508, ECO:0000269|PubMed:32459350}.; FUNCTION: [Isoform 1]: Binds to condensed chromatin in mitotic cells. {ECO:0000269|PubMed:22212508}.; FUNCTION: [Isoform 3]: Binds to condensed chromatin in mitotic cells. {ECO:0000269|PubMed:22212508}.; FUNCTION: [Isoform 4]: Binds to non-condensed chromatin in the presence of HDGF. {ECO:0000269|PubMed:22212508}.
uniprot
proteins
mass_dalton
74291
uniprot
proteins
mutagenesis
MUTAGEN 523..524; /note="RR->AA: Loss of interaction with SMARCA4."; /evidence="ECO:0000269|PubMed:32459350
uniprot
proteins
protein_family
HDGF family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17622165
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22212508
uniprot
proteins
pubmed
32459350
uniprot
proteins
pubmed
9299445
uniprot
proteins
sequence_length
669
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q925G1}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:22212508}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:22212508}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus {ECO:0000269|PubMed:22212508}. Note=Displays a punctate pattern and colocalizes with N-terminally processed HDFG. {ECO:0000269|PubMed:22212508}.
uniprot
proteins