Tnfrsf18
entrez
21936
canonical
uniprot
O35714
canonical
ensembl
ENSMUSG00000041954
resolver
ensp
ENSMUSP00000040035
resolver
ensp
ENSMUSP00000099462
resolver
genesymbol
Tnfrsf18
resolver
genesymbol_syn
Gitr
resolver
uniprot
Q540M6
resolver
uniprot
Q9JKR1
resolver
uniprot
Q9JKR2
resolver
uniprot
Q9JKR3
resolver
uniprot_entry
Q540M6_MOUSE
resolver
uniprot_entry
TNR18_MOUSE
resolver
uniprot_sec
Q9JKR1
resolver
uniprot_sec
Q9JKR2
resolver
uniprot_sec
Q9JKR3
resolver
amino_acid_sequence
MGAWAMLYGVSMLCVLDLGQPSVVEEPGCGPGKVQNGSGNNTRCCSLYAPGKEDCPKERCICVTPEYHCGDPQCKICKHYPCQPGQRVESQGDIVFGFRCVACAMGTFSAGRDGHCRLWTNCSQFGFLTMFPGNKTHNAVCIPEPLPTEQYGHLTVIFLVMAACIFFLTTVQLGLHIWQLRRQHMCPRETQPFAEVQLSAEDACSFQFPEEERGEQTEEKCHLGGRWP
uniprot
proteins
function
FUNCTION: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
25334
uniprot
proteins
mutagenesis
MUTAGEN 199; /note="S->A: Does not bind to SIVA1."; /evidence="ECO:0000269|PubMed:12478477"; MUTAGEN 201; /note="E->R: No effect on binding to SIVA1; when associated with G-204."; /evidence="ECO:0000269|PubMed:12478477"; MUTAGEN 204; /note="C->G: No effect on binding to SIVA1; when associated with R-201."; /evidence="ECO:0000269|PubMed:12478477"; MUTAGEN 209; /note="P->A: Does not bind to SIVA1."; /evidence="ECO:0000269|PubMed:12478477"; MUTAGEN 210..212; /note="EEE->RVV: Does not bind to SIVA1."; /evidence="ECO:0000269|PubMed:12478477
uniprot
proteins
pubmed
10798444
uniprot
proteins
pubmed
10836847
uniprot
proteins
pubmed
12478477
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9177197
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform A]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform B]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform C]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform D]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 154..174; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins