Arl1
entrez
64187
canonical
uniprot
P61212
canonical
ensembl
ENSRNOG00000005763
resolver
ensp
ENSRNOP00000099983
resolver
enst
ENSRNOT00000174100
resolver
genesymbol
Arl1
resolver
genesymbol_syn
Arf7
resolver
uniprot
P41276
resolver
uniprot_entry
ARL1_RAT
resolver
uniprot_sec
P41276
resolver
amino_acid_sequence
MGGFFSSIFSSLFGTREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVETVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAVIYVVDSCDRDRIGISKSELVAMLEEEELRKAILVVFANKQDMEQAMTPSEMANALGLPALKDRKWQIFKTSATKGTGLDEAMEWLVETLKSRQ
uniprot
proteins
function
FUNCTION: GTP-binding protein. Can activate phospholipase D with very low efficiency (By similarity). Important for normal function of the Golgi apparatus. {ECO:0000250, ECO:0000269|PubMed:11792819, ECO:0000269|PubMed:12972563}.; FUNCTION: GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex. Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells. {ECO:0000250|UniProtKB:P40616}.
uniprot
proteins
mass_dalton
20412
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Abolishes association with the Golgi apparatus."; /evidence="ECO:0000269|PubMed:11792819"; MUTAGEN 31; /note="T->N: Accumulation of GDP-bound form."; /evidence="ECO:0000269|PubMed:11792819"; MUTAGEN 71; /note="Q->L: Accumulation of GTP-bound form."; /evidence="ECO:0000269|PubMed:11792819
uniprot
proteins
protein_family
Arf family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11792819
uniprot
proteins
pubmed
12972563
uniprot
proteins
pubmed
14718928
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8195219
uniprot
proteins
sequence_length
181
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:12972563}; Peripheral membrane protein {ECO:0000269|PubMed:12972563}; Cytoplasmic side {ECO:0000269|PubMed:12972563}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P40616}. Membrane {ECO:0000250|UniProtKB:P40616}; Lipid-anchor {ECO:0000250|UniProtKB:P40616}.
uniprot
proteins