Myl2
entrez
363925
canonical
uniprot
P08733
canonical
ensembl
ENSRNOG00000030848
resolver
ensembl
ENSRNOG00055013348
resolver
ensembl
ENSRNOG00060001997
resolver
ensembl
ENSRNOG00065007469
resolver
ensp
ENSRNOP00000039707
resolver
ensp
ENSRNOP00000076784
resolver
ensp
ENSRNOP00055018543
resolver
ensp
ENSRNOP00060002121
resolver
ensp
ENSRNOP00065008540
resolver
enst
ENSRNOT00055022880
resolver
enst
ENSRNOT00060003137
resolver
enst
ENSRNOT00065011694
resolver
genesymbol
Myl2
resolver
genesymbol_syn
Mlc2
resolver
uniprot
A0JMZ7
resolver
uniprot_entry
MLRV_RAT
resolver
uniprot_sec
A0JMZ7
resolver
amino_acid_sequence
MSPKKAKKRLEGGSSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAALGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGSLKADYVREMLTTQAERFSKEEIDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD
uniprot
proteins
function
FUNCTION: Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (PubMed:15331360). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity). {ECO:0000250|UniProtKB:P51667, ECO:0000269|PubMed:15331360}.
uniprot
proteins
mass_dalton
18880
uniprot
proteins
post_translational_modification
PTM: N-terminus is methylated by METTL11A/NTM1. {ECO:0000250|UniProtKB:P51667}.; PTM: Phosphorylated by MYLK3 and MYLK2; promotes cardiac muscle contraction and function (By similarity) (PubMed:17885681). Dephosphorylated by PPP1CB complexed to PPP1R12B (PubMed:16431080). The phosphorylated form in adult is expressed as gradients across the heart from endocardium (low phosphorylation) to epicardium (high phosphorylation); regulates cardiac torsion and workload distribution (By similarity). {ECO:0000250|UniProtKB:P51667, ECO:0000269|PubMed:16431080, ECO:0000269|PubMed:17885681}.
uniprot
proteins
pubmed
1379240
uniprot
proteins
pubmed
15331360
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16431080
uniprot
proteins
pubmed
17885681
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2808370
uniprot
proteins
pubmed
3005270
uniprot
proteins
pubmed
3380697
uniprot
proteins
sequence_length
166
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, A band {ECO:0000269|PubMed:17885681}.
uniprot
proteins