Kcnt2
entrez
304827
canonical
uniprot
Q6UVM4
canonical
ensembl
ENSRNOG00000013312
resolver
ensp
ENSRNOP00000017884
resolver
ensp
ENSRNOP00000093596
resolver
enst
ENSRNOT00000017884
resolver
enst
ENSRNOT00000113684
resolver
genesymbol
Kcnt2
resolver
genesymbol_syn
Slick
resolver
uniprot
A0A8I6AJ80
resolver
uniprot
A0A8L2UJ52
resolver
uniprot_entry
A0A8I6AJ80_RAT
resolver
uniprot_entry
A0A8L2UJ52_RAT
resolver
uniprot_entry
KCNT2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Are normally in a closed state unless activated by an increase in intracellular Na(+) and Cl(-) (PubMed:14684870, PubMed:17699666, PubMed:29069600). Inhibited upon stimulation of G protein-coupled receptors, such as CHRM1 and GRM1 (By similarity). There is conflicting data about the effect of ATP on KNCT2 channels activity. Intracellular ATP was initially report to inhibit the channel activity (By similarity). However, others studies conclude that KNCT2 channels are not inhibited by intracellular ATP (PubMed:17699666). {ECO:0000250|UniProtKB:Q6UVM3, ECO:0000269|PubMed:14684870, ECO:0000269|PubMed:17699666, ECO:0000269|PubMed:29069600}.
uniprot
proteins
amino_acid_sequence
MVDLESEVPPLPPRYRFRDLLLGDQGWQNDDRVQVEFYMNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLSCLLYIIRVLLEKPSQGNDWSHIFWVNRSLPLWGLQVSVALISLFETILLGYLSYKGNIWEQILRVPFILEIINAVPFIISIFWPTLRNLFVPVFLNCWLAKHALENMINDLHRAIQRTQSAMFNQVLILISTLLCLIFTCICGIQHLERIGKKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPMWSQRVIYLQGSALKDQDLLRAKMDNAEACFILSSRCEVDRTSSDHQTILRAWAVKDFAPNCPLYVQILKPENKFHIKFADHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQCVCLCCREGQQSPEQWQKTYGRCSGNEVYHIVLEESTFFAEYEGKSFTYASFHAHKKFGVCLVGVRREDNKNILLNPGPRYIMNASDICFYINITKEENSAFKNQDQQRKSNVSRSFYHGPSRLPVHSIIASMGTVAIDLQDTSCRAASGPTLALPSEGGKELRRPSIAPVLEVADTSSIQTCDLLSDQSEDETTPDEETSSNLEYAKGYPPYSPYIGSSPTFCHLLQEKVPFCCLRLDKSCQHNYYEDAKAYGFKNKLIIVAAETAGNGLYNFIVPLRAYYRPKKELNPIVLLLDNPPDMHFLDAICWFPMVYYMVGSIDNLDDLLRCGVTFAANMVVVDKESTMSAEEDYMADAKTIVNVQTLFRLFSSLSIITELTHPANMRFMQFRAKDCYSLALSKLEKKERERGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMISITRLLLGLDTIPGSGFLCSMKITEDDLWIRTYARLYQKLCSSTGDVPIGIYRTESQKLTTSESQISISVEEWEDTKDVKDPGHHRSIHRNSTSSDQSDHPLLRRKSMQWARRLSRKGPKHSGKTAEKITQQRLNLYRRSERQELAELVKNRMKHLGLSTVGYDEMNDHQSTLSYILINPSPDTRLELNDVVYLIRPDPLSYLPNSEPSRKNSICNAAVQDSREETQL
uniprot
proteins
function
FUNCTION: Sodium-activated and chloride-activated potassium channel. Produces rapidly activating outward rectifier K(+) currents (PubMed:14684870, PubMed:17699666, PubMed:19403831, PubMed:29069600). Contributes to regulate neuronal excitability (PubMed:29069600). {ECO:0000269|PubMed:14684870, ECO:0000269|PubMed:17699666, ECO:0000269|PubMed:19403831, ECO:0000269|PubMed:29069600}.
uniprot
proteins
mass_dalton
131100
uniprot
proteins
mutagenesis
MUTAGEN 240; /note="F->L: Loss of chloride-activated potassium channel activity. Loss of potassium selectivity. Inhibited by chloride. Expression in primary dorsal root ganglion neurons induces membrane hyperexcitability and neuronal toxicity."; /evidence="ECO:0000269|PubMed:29069600"; MUTAGEN 276; /note="Q->E: Greatly increases unitary conductance of the channel; when associated with 279-E."; /evidence="ECO:0000269|PubMed:19403831"; MUTAGEN 279; /note="Y->E: Greatly increases unitary conductance of the channel; when associated with 276-E."; /evidence="ECO:0000269|PubMed:19403831"; MUTAGEN 1032; /note="G->S: Loss of channel inactivation by ATP."; /evidence="ECO:0000269|PubMed:14684870
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain inhibits channel activity. {ECO:0000250|UniProtKB:Q6UVM3}.
uniprot
proteins
protein_family
Calcium-activated (TC 1.A.1.3) subfamily
uniprot
proteins
protein_family
KCa4.2/KCNT2 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
14684870
uniprot
proteins
pubmed
15717307
uniprot
proteins
pubmed
16687497
uniprot
proteins
pubmed
17699666
uniprot
proteins
pubmed
19403831
uniprot
proteins
pubmed
29069600
uniprot
proteins
sequence_length
1142
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15717307, ECO:0000269|PubMed:16687497, ECO:0000269|PubMed:19403831}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 64..84; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 138..158; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 161..173; /note="Helical; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 199..219; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 257..277; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins