Kif20b
entrez
240641
canonical
uniprot
Q80WE4
canonical
ensembl
ENSMUSG00000024795
resolver
ensp
ENSMUSP00000084599
resolver
ensp
ENSMUSP00000153034
resolver
genesymbol
Kif20b
resolver
genesymbol_syn
Mphosph1
resolver
uniprot
B7ZWN1
resolver
uniprot
E9QPW5
resolver
uniprot
Q3V347
resolver
uniprot
Q80VC0
resolver
uniprot
Q8BLI2
resolver
uniprot
Q99PT5
resolver
uniprot_entry
B7ZWN1_MOUSE
resolver
uniprot_entry
KI20B_MOUSE
resolver
uniprot_sec
E9QPW5
resolver
uniprot_sec
Q3V347
resolver
uniprot_sec
Q80VC0
resolver
uniprot_sec
Q8BLI2
resolver
uniprot_sec
Q99PT5
resolver
amino_acid_sequence
MESHLNPDGVPRPSYVFSADPIARPLEINFDGVKLDLSHEFSLVASNPAANSLGSKNYLQVCLRIRPFTQSEKEHEAEGCVQVLDSQSVLLKDPQSILGHLSEKSSGQVAQKFSFSKVFGPETSQKEFFLGCIMQPVKDLLEGHSRLIFTYGLTNSGKTYTFQGTEENIGILPRTLNVLFDSLQERLYTKMSFKPHRCREYLKLSSDQEKEESANKNTLLRQIKEVTIHNDSYDVLCGHLTNSLTIPEFEESVNSCDQSSLNVDNIKYSVWVSFFEIYNESIYDLFVPVSSKFQKRKMLRLSQDIKGYSFIKDLQWVQVSDSKEAYRLLKLGVKHQSVAFTKLNNASSRSHSIFTIRILQIEDSEIPRVTRVSELSLCDLAGSERSMKTQNEGERLREAGNINTSLLTLGKCINVLKNSEKSKVQHVPFRESKLTHYFQSFFTGKGKICMIINISQSCSAYDETLNVLKFSTTAQRVYVPDTLSSSQEKSFASNKSLQDVSLDSNLDNKILNVKRKTVSWENSLEDVLENEDLVEDLEENEETQNMETELTDEDSDKSLEECRVSTCHKKNKELLDLIEKLNKRLINENKEKLTLELKIREEVTQEFTQYWSQREADFKETLLHEREILEENAERRLAIFKDLVGKCDSQDEPTNRICDIELETEEAHNYVGVEDIFHSLQDDVTDIKKQAELAHLYITSLVDPQEAIACLQLKFNQVKAELAETKEELIKAQEELKNRESNSLVQALKTSSKVDTSLTSNKSTCNETSEMPKNSRAQTHSERKRLNEDGLQLGEPPAKKGLILVSPPITEEQNKMGEMQQSVSEVVEGNRVLKEKNEELKRLLTIGENELRNEKEEKAELNKQVVSLQQQLRFFEEKNSSLRADVEQIQASYNSAVAELQTQKAVNQEQRDRILKLSQEMETAARSIESNVSQIKQMQTKIDELRSLDSPSHISKIDLLNLQDLSSGAKGDNCLNTSQQLPGGDFSSTWVKEYHTQEISRENSFHASIEAIWEECKEIVKASSKKSHQIQGLEEQIEKLQVEVKGYREENSDLRAQESQGKNRDHQLKEKESLIQQLREELQEKSVSLRVQVQLVAEREQALSELSQDVTCYKAKIKDLEVIVETQKDECKRLVELEQSILEKESAILKLEANLKECEAKHQDHIRTNDLSAKEVKFREEVTRLANNLHDTKQLLQSKEEENEISRQETEKLKEELAANSILTQNLKADLQKKEEDCAELKEKFIDAKKQIEQVQREVSVMRDEEKLLRIKINELEKKKNQYSQDLDMKQRTIQQLKEQLSNQKMEEAVQQYEKVCKDLSVKEKLVEDMRLTLVEQEQTQAEQDRVLEAKSEEADWLATELDKWKEKFKDLETRSNQRLNTGTMDDLDVLTRKFSKLQDELQESEEKYKADRKKWLEEKAVLTTQAKEAENVRNREMRKYADDRERCLKLQNEVETLTAQLAEKNSELQKWREERDQLVTAVETQMKALLSSCKHKDEEIQELRKAAAKSTGTENQTMNPKPEYNDSVDLGGVETEPQSTSLEISRNTAEDGSVVLDSCEVSTENVQSTRFPKPELEIQFTPLQPNKMAVKHPGCPTPVTIKIPKARKRKSGEVEEDLVKCENKKNSTPRSNVKFPVSEHRNSPVKKEQKVSVGPSSKKTYSLRSQASTVSANIASKKREGTLQKFGDFLQHSPTILQSKAKKIIETMSSPKLSTVEVSKENVSQPKKAKRKLYRNEISSPINISGQVILMEQKVKETDHQILKRRLRTRTAK
uniprot
proteins
function
FUNCTION: Plus-end-directed motor enzyme that is required for completion of cytokinesis (By similarity). Required for proper midbody organization and abscission in polarized cortical stem cells (PubMed:24173802). Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner (PubMed:23864681). In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex (PubMed:23864681). Involved in cerebral cortex growth (PubMed:24173802). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (By similarity). {ECO:0000250|UniProtKB:Q96Q89, ECO:0000269|PubMed:23864681, ECO:0000269|PubMed:24173802}.
uniprot
proteins
mass_dalton
203514
uniprot
proteins
mutagenesis
MUTAGEN 1047; /note="Y->F: Reduces interaction with SHTN1; when associated with A-1048."; /evidence="ECO:0000269|PubMed:23864681"; MUTAGEN 1048; /note="R->A: Reduces interaction with SHTN1; when associated with F-1047."; /evidence="ECO:0000269|PubMed:23864681
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during mitosis by CDK1. {ECO:0000250|UniProtKB:Q96Q89}.
uniprot
proteins
protein_family
Kinesin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
11416179
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23864681
uniprot
proteins
pubmed
24173802
uniprot
proteins
sequence_length
1774
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24173802}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23864681}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q96Q89}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q96Q89}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q96Q89}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:24173802}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q96Q89}. Midbody {ECO:0000269|PubMed:23864681, ECO:0000269|PubMed:24173802}. Cell projection, axon {ECO:0000269|PubMed:23864681}. Cell projection, growth cone {ECO:0000269|PubMed:23864681}. Note=Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules (By similarity). Localized to the central spindle during cytokinetic furrowing and with the midbody during abscission (PubMed:24173802). A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase. During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone. At anaphase it is concentrated in the midbody (By similarity). Colocalized partially along microtubules in primary neurons (PubMed:23864681). Colocalized with SHTN1 along microtubules to the tip of the growing cone in primary hippocampal neurons (PubMed:23864681). Localized in midbodies between dividing radial progenitors in the ventricular zone (PubMed:23864681). Colocalized with PRC1 in the nucleus of bladder carcinoma cells at the interphase. Colocalized with PRC1 in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (By similarity). {ECO:0000250|UniProtKB:Q96Q89, ECO:0000269|PubMed:23864681, ECO:0000269|PubMed:24173802}.
uniprot
proteins