Ifit1
entrez
15957
canonical
uniprot
Q64282
canonical
ensembl
ENSMUSG00000034459
resolver
ensp
ENSMUSP00000099888
resolver
enst
ENSMUST00000102824
resolver
genesymbol
Ifit1
resolver
genesymbol_syn
Garg16
resolver
genesymbol_syn
Ifi56
resolver
genesymbol_syn
Ifit1b
resolver
genesymbol_syn
Isg56
resolver
uniprot
Q99L77
resolver
uniprot_entry
IFIT1_MOUSE
resolver
uniprot_sec
Q99L77
resolver
amino_acid_sequence
MGENADGDQVMENLLQLRCHFTWKLLFENNDIPDLEVRISEQVQFLDIKNPLGMHNLLAYVRHLKGQQDEALQSLKEAEALIQSEQLSKRSLATWGNCAWLHYHRGSLAEAQIYLDKVEKVCKEFSSPFRYRLECAEMDCEEGWALLKCGGGNYKQAMACFAKALKVEPENPEYNTGYAVVAYRQDLDDNFISLEPLRKAVRLNPEDPYLKVLLALKLQDLGEHVEAEAHIEEALSSTSCQSYVIRYAAKYFRRKHRVDKALHLLNRALQASPSSGYLHYQKGLCYKQQISQLRTSRNRQPRRQDNVQELAQQAIHEFQETLKLRPTFEMAYVCMAEVQAEIHQYEEAERNFQKALNNKTLVAHIEQDIHLRYGRFLQFHKQSEDKAITLYLKGLKVEEKSFAWRKLLTALEKVAERRVCQNVHLVESTSLLGLVYKLKGQEKNALFYYEKALRLTGEMNPAF
uniprot
proteins
function
FUNCTION: Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E. {ECO:0000269|PubMed:21085181, ECO:0000269|PubMed:22589727, ECO:0000269|PubMed:27240734, ECO:0000269|PubMed:33454014}.
uniprot
proteins
mass_dalton
53737
uniprot
proteins
protein_family
IFIT family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16023166
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19856081
uniprot
proteins
pubmed
20950130
uniprot
proteins
pubmed
21085181
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22589727
uniprot
proteins
pubmed
27240734
uniprot
proteins
pubmed
33454014
uniprot
proteins
pubmed
7896268
uniprot
proteins
pubmed
8660659
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19856081}.
uniprot
proteins