NFAM1
entrez
150372
canonical
uniprot
Q8NET5
canonical
ensembl
ENSG00000235568
resolver
ensp
ENSP00000333680
resolver
ensp
ENSP00000718568
resolver
enst
ENST00000329021
resolver
genesymbol
NFAM1
resolver
genesymbol_syn
CNAIP
resolver
hgnc
HGNC:29872
resolver
uniprot
B0QYD0
resolver
uniprot
Q20WL2
resolver
uniprot
Q5JZ96
resolver
uniprot
Q8IUY8
resolver
uniprot
Q8TEM8
resolver
uniprot_entry
NFAM1_HUMAN
resolver
uniprot_sec
B0QYD0
resolver
uniprot_sec
Q20WL2
resolver
uniprot_sec
Q5JZ96
resolver
uniprot_sec
Q8IUY8
resolver
uniprot_sec
Q8TEM8
resolver
amino_acid_sequence
MENQPVRWRALPGLPRPPGLPAAPWLLLGVLLLPGTLRLAGGQSVTHTGLPIMASLANTAISFSCRITYPYTPQFKVFTVSYFHEDLQGQRSPKKPTNCHPGLGTENQSHTLDCQVTLVLPGASATGTYYCSVHWPHSTVRGSGTFILVRDAGYREPPQSPQKLLLFGFTGLLSVLSVVGTALLLWNKKRMRGPGKDPTRKCPDPRSASSPKQHPSESVYTALQRRETEVYACIENEDGSSPTAKQSPLSQERPHRFEDDGELNLVYENL
uniprot
proteins
function
FUNCTION: May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking. {ECO:0000269|PubMed:12615919, ECO:0000269|PubMed:15143214}.
uniprot
proteins
mass_dalton
29686
uniprot
proteins
mutagenesis
MUTAGEN 220; /note="Y->A,F: Abolishes the ITAM-mediated-activating activity."; /evidence="ECO:0000269|PubMed:12615919, ECO:0000269|PubMed:15143214"; MUTAGEN 231; /note="Y->A,F: Abolishes the ITAM-mediated-activating activity."; /evidence="ECO:0000269|PubMed:12615919, ECO:0000269|PubMed:15143214
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:15143214}.
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12615919
uniprot
proteins
pubmed
12693554
uniprot
proteins
pubmed
15143214
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Partially recruited to lipid rafts upon BCR stimulation. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 164..184; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins