CYTH3
entrez
9265
canonical
uniprot
O43739
canonical
ensembl
ENSG00000008256
resolver
ensp
ENSP00000297044
resolver
genesymbol
CYTH3
resolver
genesymbol_syn
ARNO3
resolver
genesymbol_syn
GRP1
resolver
genesymbol_syn
PSCD3
resolver
hgnc
HGNC:9504
resolver
uniprot
A4D2N8
resolver
uniprot
B7Z2V9
resolver
uniprot_entry
B7Z2V9_HUMAN
resolver
uniprot_entry
CYH3_HUMAN
resolver
uniprot_sec
A4D2N8
resolver
amino_acid_sequence
MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK
uniprot
proteins
function
FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity). {ECO:0000250|UniProtKB:O08967, ECO:0000269|PubMed:23940353, ECO:0000269|PubMed:9707577}.
uniprot
proteins
mass_dalton
46349
uniprot
proteins
mutagenesis
MUTAGEN 398..400; /note="NKK->AAA: Abolishes autoinhibition and increases guanine-nucleotide exchange activity."; /evidence="ECO:0000269|PubMed:23940353
uniprot
proteins
pubmed
10652308
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17398095
uniprot
proteins
pubmed
23940353
uniprot
proteins
pubmed
9707577
uniprot
proteins
pubmed
9742223
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane {ECO:0000250|UniProtKB:O08967}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08967}. Cell junction, adherens junction {ECO:0000250|UniProtKB:O08967}. Cell junction, tight junction {ECO:0000250|UniProtKB:O08967}. Note=Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000250|UniProtKB:O08967}.
uniprot
proteins