Tbck
entrez
271981
canonical
uniprot
Q8BM85
canonical
ensembl
ENSMUSG00000028030
resolver
ensp
ENSMUSP00000129205
resolver
genesymbol
Tbck
resolver
uniprot
E9Q1W7
resolver
uniprot
Q8BWD3
resolver
uniprot
Q8BY53
resolver
uniprot_entry
TBCK_MOUSE
resolver
uniprot_sec
E9Q1W7
resolver
uniprot_sec
Q8BWD3
resolver
uniprot_sec
Q8BY53
resolver
amino_acid_sequence
MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERSLEDLLRERKPVSHSTVLCIAYEVLEGLHYLNKHGIVHRALSPHNILLDRKGHIKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIPKTTDHVPSEKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDVSERVKFLLTLGCVDDTIIVLAEEHGCLDIIKELPENVINILKKCLTFHPSKRPTPDELMKDQVFSEVSPLYTPFIKPASLFSSSLRCADLTLPEDISDLCKDIDNDYLAERSIEEVYYLWCLAGGDLEKELINKEIIRSKPPVCTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIRERDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESVNLFCWTPKSATYRQHAQPPKPASESSVVRSSAPYFSAECTDPPKTDLSRESIPLSDLKSEVSPRISAEDLIDLCELTVTGHFKTPTKKTKSSKPKLLVVDIRNSEDFVRGHIAGSINIPFSAAFTAEGELSQGPYTTMLHNFKGKVIVVVGHVAKQTAEFAAHLVKMKYPRVCILDGGINKIRPTGLLTVPSPQI
uniprot
proteins
function
FUNCTION: Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction (By similarity). Also involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the control of actin-cytoskeleton organization (By similarity). {ECO:0000250|UniProtKB:Q8TEA7}.
uniprot
proteins
mass_dalton
100640
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
893
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TEA7}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8TEA7}. Midbody {ECO:0000250|UniProtKB:Q8TEA7}. Early endosome {ECO:0000250|UniProtKB:Q8TEA7}. Note=Mainly localized in the cytoplasm during interphase. During metaphase, TBCK accumulates at the mitotic spindle. At the end of mitosis, it is detected at the midbody. {ECO:0000250|UniProtKB:Q8TEA7}.
uniprot
proteins