Slco4c1
entrez
432363
canonical
uniprot
Q71MB6
canonical
ensembl
ENSRNOG00000022711
resolver
ensp
ENSRNOP00000037089
resolver
enst
ENSRNOT00000033958
resolver
genesymbol
Slco4c1
resolver
genesymbol_syn
Oatp4c1
resolver
genesymbol_syn
Slc21a20
resolver
uniprot
F1LRH8
resolver
uniprot_entry
F1LRH8_RAT
resolver
uniprot_entry
SO4C1_RAT
resolver
amino_acid_sequence
MQGSKGVENPAFVPSSPDTPRRASASPSQVEVSAVASRNQNGGSQPRESEDPQKSTEPSPPSSTLPASDEPPGSQLSELEEGPCGWRNFHPQCLQRCNNPKGFLLHYCLLALTQGIVVNGLVNISISTIEKRYEMKSSLTGLISSSYDISFCVLSLFVSFFGERGHKPRWLAFASFMIGLGALVFSLPHFFSGRYELGTIFEDTCLTRNSTRCASSTSLLSNYFYVFVLGQLLLGTGGTPLYTLGTAFIDDSVPTHKSSLYIGIGYSMSILGPAIGYVLGGQLLTMYIDVAMGQSSDLTEDDPRWLGAWWIGFLLAWLFAWSLIMPFSCFPKHLPGTAKIQAGKTSQTHQNNSTSFQHMDENFGKSIKDFPTAVKNLMRNTVFICLVLSTTSEALVTTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGVLVSKFKMKCKNTMKFALCTSGVALMLSFVFIYAKCENGPFAGVSESYNGTGEMGNLTAPCNANCNCLRSYYYPLCGSDGVQYFSPCFAGCLNSVSNRKPKAYYNCSCIERKVDITSTAXSPDFEARAGKCKTQCSNLPIFLGIFFITVIFTFMAGTPITVSILRCVNHRQRSLALGVQFMLLRLLGTIPGPIIFGVTIDSTCVLWDINECGTKGACWIYDNIRMAHMLVAISVTCKVITIFFNGLAIVLYKPPPPGTEVSFQSQNVVVSTITVEEDLNKIENEG
uniprot
proteins
function
FUNCTION: Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney. Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate (PubMed:14993604). Transport is independent of sodium, chloride ion, and ATP (PubMed:14993604, PubMed:22768102). Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter (PubMed:14993604, PubMed:22768102). The driving force for this transport activity is currently not known (PubMed:22768102). The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (PubMed:14993604, PubMed:22768102). Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (PubMed:22768102). Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)-dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker). Can act bidirectionally, suggesting a dual protective role of this transport protein; exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) (By similarity). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity). {ECO:0000250|UniProtKB:Q6ZQN7, ECO:0000250|UniProtKB:Q8BGD4, ECO:0000269|PubMed:14993604, ECO:0000269|PubMed:22768102, ECO:0000303|PubMed:14993604, ECO:0000303|PubMed:22768102}.
uniprot
proteins
mass_dalton
78648
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
14993604
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
22768102
uniprot
proteins
sequence_length
724
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:14993604}; Multi-pass membrane protein {ECO:0000269|PubMed:14993604}. Apical cell membrane {ECO:0000269|PubMed:22768102}. Note=Detected at the basolateral membrane of the proximal tubule cell in the kidney. {ECO:0000269|PubMed:14993604}.
uniprot
proteins
transmembrane_region
TRANSMEM 102..122; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 169..193; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 219..249; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 270..290; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 307..331; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 377..398; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 419..442; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 447..470; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 581..603; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 613..638; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 673..690; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins