Map3k1
entrez
116667
canonical
uniprot
Q62925
canonical
ensembl
ENSRNOG00000013177
resolver
ensp
ENSRNOP00000088035
resolver
enst
ENSRNOT00000114100
resolver
genesymbol
Map3k1
resolver
genesymbol_syn
Mekk
resolver
genesymbol_syn
Mekk1
resolver
uniprot
A0A8I6A5B8
resolver
uniprot_entry
A0A8I6A5B8_RAT
resolver
uniprot_entry
M3K1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by autophosphorylation on Thr-1381 and Thr-1393 following oligomerization. {ECO:0000269|PubMed:11784851}.
uniprot
proteins
amino_acid_sequence
MAAAAGDRASSSGFPGAAAASPEAGGGGGALQGSGAPAAGAGLLRETGSAGRERADWRRQQLRKVRSVELDQLPEQPLFLTASPPCPSTSPSPEPADAAAGASGFQPAAGPPPPGAASRCGSHSAELAAARDSGARSPAGAEPPSAAAPSGREMENKETLKGLHKMDDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGSEMSNLAAELQGEGQAGSAAPAPKGRRSPSPGSSPSGRSGKPESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETSRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCGRGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNCHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVDSPTSLRGVQQPSSPQQPVAGSQRRNQESNFNLTHYGTQQIPPAYKDLAEPWIQAFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGTSGGGSGGSLSAGAASGSSQPSISGDVVEAFCSVLSIVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLRPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGVGGVDYVLSCILGNQAESNNWQELLGRLCLIDRLLLEISAEFYPHIVSTDVSQAEPVEIRYKKLLSLLAFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPPLFSKLVTMLSASGSSHFARMRRRLMAIADEVEIAEVIQLGSEDTLDGQQDSSQALAPPRYPESSSLEHTAHVEKTGKGLKATRLSASSEDISDRLAGVSVGLPSSATTEQPKPTVQTKGRPHSQCLNSSPLSPPQLMFPAISAPCSSAPSVPAGSVTDASKHRPRAFVPCKIPSASPQTQRKFSLQFQRTCSENRDSEKLSPVFTQSRPPPSSNIHRAKASRPVPGSTSKLGDASKNSMTLDLNSASQCDDSFGSGSNSGSAVIPSEETAFTPAEDKCRLDVNPELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAESDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKANEPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGASVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Component of a protein kinase signal transduction cascade (PubMed:11784851). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:11784851). May phosphorylate the MAPK8/JNK1 kinase (By similarity). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:11784851). {ECO:0000250|UniProtKB:P53349, ECO:0000269|PubMed:11784851}.
uniprot
proteins
mass_dalton
161315
uniprot
proteins
mutagenesis
MUTAGEN 1350; /note="D->N: Loss of kinase activity and of autophosphorylation activity."; /evidence="ECO:0000269|PubMed:11784851"; MUTAGEN 1369; /note="D->A: Inactivation."; /evidence="ECO:0000269|PubMed:8643568"; MUTAGEN 1381; /note="T->A: Loss of kinase activity and activation by autophosphorylation; when associated with T-1393."; /evidence="ECO:0000269|PubMed:11784851"; MUTAGEN 1393; /note="T->A: Loss of kinase activity and activation by autophosphorylation; when associated with T-1381."; /evidence="ECO:0000269|PubMed:11784851
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000269|PubMed:11784851}.
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
11784851
uniprot
proteins
pubmed
17761173
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8643568
uniprot
proteins
sequence_length
1493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:8643568}; Peripheral membrane protein {ECO:0000269|PubMed:8643568}.
uniprot
proteins