Gpc3
entrez
14734
canonical
uniprot
Q8CFZ4
canonical
ensembl
ENSMUSG00000055653
resolver
ensp
ENSMUSP00000064131
resolver
enst
ENSMUST00000069360
resolver
genesymbol
Gpc3
resolver
uniprot
Q3TWB2
resolver
uniprot_entry
GPC3_MOUSE
resolver
uniprot_entry
Q3TWB2_MOUSE
resolver
amino_acid_sequence
MAGTVRTACLLVAMLLGLGCLGQAQPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQMMNPGLPESVLDINECLRGARRDLKVFGSFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNGGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKILKVAHVEHEETLSSRRRELIQKLKSFINFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSVPKGKVLDKSLDEEGLESGDCGDDEDECIGSSGDGMVKVKNQLRFLAELAYDLDVDDAPGNKQHGNQKDNEITTSHSVGNMPSPLKILISVAIYVACFFFLVH
uniprot
proteins
function
FUNCTION: Cell surface proteoglycan (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (PubMed:18477453, PubMed:23665349). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (PubMed:18477453). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (By similarity). Positively regulates the non-canonical Wnt signaling pathway (PubMed:15537637). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (PubMed:23665349). Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (PubMed:10964473). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (PubMed:11180950). Required for coronary vascular development (PubMed:19733558). Plays a role in regulating cell movements during gastrulation (By similarity). {ECO:0000250|UniProtKB:P51654, ECO:0000250|UniProtKB:Q6V9Y8, ECO:0000269|PubMed:10964473, ECO:0000269|PubMed:11180950, ECO:0000269|PubMed:15537637, ECO:0000269|PubMed:18477453, ECO:0000269|PubMed:19733558, ECO:0000269|PubMed:23665349}.
uniprot
proteins
mass_dalton
65332
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains heparan sulfate and/or chondroitin sulfate. {ECO:0000250|UniProtKB:P51654}.; PTM: Cleaved intracellularly by a furin-like convertase to generate 2 subunits, alpha and beta, which remain associated through disulfide bonds and are associated with the cell surface via the GPI-anchor. This processing is essential for its role in inhibition of hedgehog signaling. A second proteolytic event may result in cleavage of the protein on the cell surface, separating it from the GPI-anchor and leading to its shedding from the cell surface. {ECO:0000250|UniProtKB:P51654}.
uniprot
proteins
protein_family
Glypican family
uniprot
proteins
pubmed
10402475
uniprot
proteins
pubmed
10964473
uniprot
proteins
pubmed
11180950
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15537637
uniprot
proteins
pubmed
18477453
uniprot
proteins
pubmed
19733558
uniprot
proteins
pubmed
23665349
uniprot
proteins
sequence_length
579
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P13265}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P13265}; Extracellular side {ECO:0000250|UniProtKB:P13265}.
uniprot
proteins