TTLL6
entrez
284076
canonical
uniprot
Q8N841
canonical
ensembl
ENSG00000170703
resolver
ensp
ENSP00000377043
resolver
ensp
ENSP00000399211
resolver
enst
ENST00000433608
resolver
genesymbol
TTLL6
resolver
genesymbol_syn
TTL.6
resolver
hgnc
HGNC:26664
resolver
uniprot
A0AAA9X7X9
resolver
uniprot
B4DZJ5
resolver
uniprot
C9J233
resolver
uniprot
Q24KB1
resolver
uniprot
Q24KB2
resolver
uniprot
Q24KB6
resolver
uniprot
Q24KF3
resolver
uniprot
Q24KJ5
resolver
uniprot
Q24KN7
resolver
uniprot
Q24KS9
resolver
uniprot
Q24KX1
resolver
uniprot
Q24L13
resolver
uniprot
Q24L55
resolver
uniprot
Q24L76
resolver
uniprot
Q658K6
resolver
uniprot
Q8IYW6
resolver
uniprot
Q8NA62
resolver
uniprot_entry
A0AAA9X7X9_HUMAN
resolver
uniprot_entry
TTLL6_HUMAN
resolver
uniprot_sec
B4DZJ5
resolver
uniprot_sec
C9J233
resolver
uniprot_sec
Q24KB1
resolver
uniprot_sec
Q24KB2
resolver
uniprot_sec
Q24KB6
resolver
uniprot_sec
Q24KF3
resolver
uniprot_sec
Q24KJ5
resolver
uniprot_sec
Q24KN7
resolver
uniprot_sec
Q24KS9
resolver
uniprot_sec
Q24KX1
resolver
uniprot_sec
Q24L13
resolver
uniprot_sec
Q24L55
resolver
uniprot_sec
Q24L76
resolver
uniprot_sec
Q658K6
resolver
uniprot_sec
Q8IYW6
resolver
uniprot_sec
Q8NA62
resolver
amino_acid_sequence
MGALLLHPSRRGPAGVVASWTSSPAGRDGGVGIAGAWYFPRASSQAREMPQCPTLESQEGENSEEKGDSSKEDPKETVALAFVRENPGAQNGLQNAQQQGKKKRKKKRLVINLSSCRYESVRRAAQQYGFREGGEDDDWTLYWTDYSVSLERVMEMKSYQKINHFPGMSEICRKDLLARNMSRMLKMFPKDFRFFPRTWCLPADWGDLQTYSRSRKNKTYICKPDSGCQGKGIFITRTVKEIKPGEDMICQLYISKPFIIDGFKFDLRIYVLVTSCDPLRIFVYNEGLARFATTSYSRPCTDNLDDICMHLTNYSINKHSSNFSRDAHSGSKRKLSTFSAYLEDHSYNVEQIWRDIEDVIIKTLISAHPIIRHNYHTCFPNHTLNSACFEILGFDILLDHKLKPWLLEVNHSPSFSTDSRLDKEVKDGLLYDTLVLINLESCDKKKVLEEERQRGQFLQQCCSREMRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLNSEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQPLTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVHLTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPHLISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRSHASAMRDPCMQDQEAYSHCLISGQKGCERS
uniprot
proteins
ec_number
6.3.2.-
uniprot
proteins
function
FUNCTION: Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins. Preferentially mediates ATP-dependent long polyglutamate chain elongation over the initiation step of the polyglutamylation reaction. Preferentially modifies the alpha-tubulin tail over a beta-tail. Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions. Mediates microtubule polyglutamylation in primary cilia axoneme, which is important for ciliary structural formation and motility. Mediates microtubule polyglutamylation in motile cilia, necessary for the regulation of ciliary coordinated beating. Polyglutamylates non-tubulin protein nucleotidyltransferase CGAS, leading to CGAS DNA-binding inhibition, thereby preventing antiviral defense response. {ECO:0000250|UniProtKB:A4Q9E8}.
uniprot
proteins
mass_dalton
101292
uniprot
proteins
mutagenesis
MUTAGEN 444..446; /note="KKK->EEE: Decreased binding to microtubules and polyglutamylase activity; when associated with E-464 and E-467."; /evidence="ECO:0000269|PubMed:25959773"; MUTAGEN 464; /note="R->E: Decreased binding to microtubules and polyglutamylase activity; when associated with 396-E--E-446 and E-467."; /evidence="ECO:0000269|PubMed:25959773"; MUTAGEN 467; /note="R->E: Decreased binding to microtubules and polyglutamylase activity; when associated with 396-E--E-446 and E-464."; /evidence="ECO:0000269|PubMed:25959773
uniprot
proteins
protein_family
Tubulin--tyrosine ligase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15890843
uniprot
proteins
pubmed
16443334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
22246503
uniprot
proteins
pubmed
25959773
uniprot
proteins
sequence_length
891
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A4Q9E8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A4Q9E8}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:22246503}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22246503}. Note=CEP41 is required for its transport between the basal body and the cilium axoneme. {ECO:0000269|PubMed:22246503}.
uniprot
proteins