Tfam
entrez
83474
canonical
uniprot
Q91ZW1
canonical
ensembl
ENSRNOG00000000613
resolver
ensembl
ENSRNOG00055020990
resolver
ensembl
ENSRNOG00060025082
resolver
ensembl
ENSRNOG00065026909
resolver
ensp
ENSRNOP00000000753
resolver
enst
ENSRNOT00000000753
resolver
genesymbol
Tfam
resolver
uniprot
Q9WTM7
resolver
uniprot_entry
TFAM_RAT
resolver
uniprot_sec
Q9WTM7
resolver
amino_acid_sequence
MALFRGMWGVLRTLGRTGVEMCAGCGGRIPSPVSLICIPKCFSSLGNYPKKPMSSYLRFSTEQLPKFKAKHPDAKVSELIRKIAAMWRELPEAEKKVYEADFKAEWKVYKEAVSKYKEQLTPSQLMGLEKEARQKRLKKKAQIKRRELILLGKPKRPRSAYNIYVSESFQEAKDESAQGKLKLVNQAWKNLSHDEKQAYIQLAKDDRIRYDNEMKSWEEQMAEVGRSDLIRRSVKRPPGDISEN
uniprot
proteins
function
FUNCTION: [Isoform Mitochondrial]: Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA (By similarity). {ECO:0000250|UniProtKB:Q00059}.; FUNCTION: [Isoform Nuclear]: May also function as a transcriptional activator or may have a structural role in the compaction of nuclear DNA during spermatogenesis. {ECO:0000250|UniProtKB:P40630}.
uniprot
proteins
mass_dalton
28187
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PKA within the HMG box 1 impairs DNA binding and promotes degradation by the AAA+ Lon protease. {ECO:0000250}.
uniprot
proteins
pubmed
10902920
uniprot
proteins
pubmed
11943465
uniprot
proteins
pubmed
12198131
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
30120151
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion {ECO:0000250|UniProtKB:Q00059}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:Q00059}.; SUBCELLULAR LOCATION: [Isoform Nuclear]: Nucleus.
uniprot
proteins