Q9WV70
uniprot
Q9WV70
canonical
amino_acid_sequence
MAASRAPRRRLEDLSVDEFLASGFESGSESELEGAAEERRARGAAWNRERRGARTSPGPAGRLRKGRASEHKDQLSRLKDRDPEFYKFLQENDRSLLDFSDSDSSAEEEEPFHSLPDTLEEASETEEDGGEDSDALPRGLRSKKNEPVPVTLAMVERWRQGSRHHLTPRLFHEVVQAFRAAVATTQGEQEAAETCRFQVADSAVFNALVTFCIRDLCGCLQKLLFGKTPKDSNRLLLPSSSPLWGKLRVDVKSYLSAVVQLAACLAEATVSAAVLQHISSLVPYFLTFPKQCRMLLKRMVVLWSTGEESLRVLAFLVLIRVCRHKKEAFLGPILKQMYIMYVRNCKFTSPSTLPLISFMQRTLTEMLALDPSVSYQHAFLYIRQLAVHLRNAMTTGKKETHQSVYNWQYVHCLYLWCRVLSTLGSSEILQPLLYPLSQIIIGCIKLLPTARFYPLRMHCVRALTLLSQTIGTFIPVLPFILEIFQQVDFNRRPGRMSSKPINFSVILKLSSTNLQEKAYRDGLLEQLCDLILEYLHSQAHSIAFPELVLPTVLQLKSFLRECKVANYCRQVRQLLEKVQENARHIESLRQSATFSVSDRTAVDAWEKQVREEGTPLTRYYGHWKKLRDREIQLEISGKERLEDLNFPEIKRRKVEDRKDEDRKELKDLFELDSSEGEDSTDFFERGVPRLPEAHQGLKEDQEEEDKEEGDSDSEDGDTDTGVDLSELWQLAQGAQDELEDLQLSEED
uniprot
proteins
function
FUNCTION: Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
85424
uniprot
proteins
protein_family
NOC2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16322561
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
747
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis (By similarity). {ECO:0000250}.
uniprot
proteins