Ints10
entrez
70885
canonical
uniprot
Q8K2A7
canonical
ensembl
ENSMUSG00000031864
resolver
ensp
ENSMUSP00000034328
resolver
ensp
ENSMUSP00000069908
resolver
ensp
ENSMUSP00000105870
resolver
ensp
ENSMUSP00000105871
resolver
ensp
ENSMUSP00000193353
resolver
ensp
ENSMUSP00000193361
resolver
ensp
ENSMUSP00000193368
resolver
ensp
ENSMUSP00000193371
resolver
ensp
ENSMUSP00000193374
resolver
enst
ENSMUST00000034328
resolver
enst
ENSMUST00000070713
resolver
enst
ENSMUST00000110242
resolver
genesymbol
Ints10
resolver
uniprot
A0A0R4J0V1
resolver
uniprot
E9Q360
resolver
uniprot
Q8BYC2
resolver
uniprot
Q8BZI9
resolver
uniprot
Q9D5U1
resolver
uniprot_entry
A0A0R4J0V1_MOUSE
resolver
uniprot_entry
E9Q360_MOUSE
resolver
uniprot_entry
INT10_MOUSE
resolver
uniprot_sec
Q8BYC2
resolver
uniprot_sec
Q8BZI9
resolver
uniprot_sec
Q9D5U1
resolver
amino_acid_sequence
MSAQGDCEFLVQRARELVPQDLWAAKAWLITARSLYPADFNIQYEMYTIERNAERTATAGRLLYDMFVNFPDQPVVWREISIITSALRNDSQDKQTQFLRSLFETLPGRVQCEMLLKVTEQCFNTLERSEMLLLLLRRFPETVVQHGVGLGEALLEAETIEEQDSPVNCFRKLFVCDVLPLIINNHDVRLPANLLYKYLNKAAEFYINYVTRSTQSENQHQGAQDTSDLMSPSKRSSQKYIIEGLTEKSSHIVDPWERLFKILNVVGMRCEWQMDKGRRSCSDLLHRMKELCRYMNSFDSEAHNNYKNQVLYSTMLVFFKSAFQYVSSIQPSLFQGPNAPSQVPLILLEDVANVYGDVEIDRSKHIHKKRKLAEGREKTMSSDDEECSAKGRNRHIVVSKADLSNSIEVLESFKLARESWELLYSLEFLDKEFTRICLAWKTDTWLWLRIFLTDMIIYQGQYKKAIASLHHLAALQGSLSQPQITGQGTLEHQRALIQLATCHFALGEYRMTCEKVLDLMCYMVLPIQDGGKPQEEPSKVKPKCRKGLDLKLLPCTSKAIMPYCLHLMLACFKLRAFTDSRDDMALGHVIVLLQQEWPRGENLFLKAISKICQQGNFQYENFFSYVTNIDMLEEFAYLRTQEGGKIHLELLPNQGMLIKHHTVTRGITKGVKEDFRLAMERQVSRCGENLMAVLHRFCINEKILLLQTLT
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS10 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex. {ECO:0000250|UniProtKB:Q9NVR2}.
uniprot
proteins
mass_dalton
82020
uniprot
proteins
protein_family
Integrator subunit 10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
710
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NVR2}.
uniprot
proteins