Tub
entrez
22141
canonical
uniprot
P50586
canonical
ensembl
ENSMUSG00000031028
resolver
ensp
ENSMUSP00000033341
resolver
genesymbol
Tub
resolver
genesymbol_syn
Rd5
resolver
uniprot
Q4VA41
resolver
uniprot_entry
Q4VA41_MOUSE
resolver
uniprot_entry
TUB_MOUSE
resolver
amino_acid_sequence
MTSKPHSDWIPYSVLDDEGSNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSIASVQLGATRPPAPASAKKSKGAAASGGQGGAPRKEKKGKHKGTSGPATLAEDKSEAQGPVQILTVGQSDHDKDAGETAAGGGAQPSGQDLRATMQRKGISSSMSFDEDEDEDENSSSSSQLNSNTRPSSATSRKSIREAASAPSPAAPEPPVDIEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVCIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Tub are the cause of maturity-onset obesity, insulin resistance and sensory deficits.
uniprot
proteins
function
FUNCTION: Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity). {ECO:0000250, ECO:0000269|PubMed:10591637, ECO:0000269|PubMed:11375483}.
uniprot
proteins
mass_dalton
55362
uniprot
proteins
mutagenesis
MUTAGEN 330; /note="K->A: Abolishes interaction with phosphatidylinositol 4,5-bisphosphate and reduces secretion by 40%; when associated with A-332."; /evidence="ECO:0000269|PubMed:11375483, ECO:0000269|PubMed:19695251"; MUTAGEN 332; /note="R->A: Abolishes interaction with phosphatidylinositol 4,5-bisphosphate and reduces secretion by 40%; when associated with A-330."; /evidence="ECO:0000269|PubMed:11375483, ECO:0000269|PubMed:19695251
uniprot
proteins
protein_family
TUB family
uniprot
proteins
pubmed
10591637
uniprot
proteins
pubmed
11375483
uniprot
proteins
pubmed
19695251
uniprot
proteins
pubmed
19837063
uniprot
proteins
pubmed
8606774
uniprot
proteins
pubmed
8612280
uniprot
proteins
sequence_length
505
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Secreted. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway.
uniprot
proteins