Sgms2
entrez
310849
canonical
uniprot
Q4JM44
canonical
ensembl
ENSRNOG00000011284
resolver
ensp
ENSRNOP00000015020
resolver
enst
ENSRNOT00000015020
resolver
genesymbol
Sgms2
resolver
uniprot
A0A0G2JSK7
resolver
uniprot
Q5U2Z1
resolver
uniprot_entry
A0A0G2JSK7_RAT
resolver
uniprot_entry
SMS2_RAT
resolver
uniprot_sec
Q5U2Z1
resolver
amino_acid_sequence
MDIIETAKLEGHLESQTNNSTNTYTSPTEAVEEEDKNGKGKPKTLSNGLRKGAKKYPDYIQISMPNDSRNKLPLEWWKTGIAFVYALFNLILTTVMITVVHERVPPKELSPPLPDKFFDYVDRVKWAFSVSEINGMVLVGLWLTQWLFLRYKSIVGRRFFFIMGTLYLYRCITMYVTTLPVPGMHFQCAPKLNGDSQAKIQRILRLLSGGGLSITGSHILCGDFLFSGHTVVLTLTYLFIKEYSPRHFWWYHLVCWLLSAAGIICILVAHEHYTVDVIIAYYITTRLFWWYHSMANEKNLKVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGEDNEKST
uniprot
proteins
ec_number
2.7.8.27
uniprot
proteins
function
FUNCTION: Sphingomyelin synthase that primarily contributes to sphingomyelin synthesis and homeostasis at the plasma membrane. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction appears to depend on the levels of CER and DAG in the plasma membrane (By similarity). Does not use free phosphorylcholine or CDP-choline as donors (By similarity). Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to ceramide (CER) to form ceramide phosphoethanolamine (CPE) (By similarity). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (By similarity). To a lesser extent, plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (PubMed:21980337). Required for normal bone matrix mineralization (By similarity). {ECO:0000250|UniProtKB:Q8NHU3, ECO:0000269|PubMed:21980337}.
uniprot
proteins
mass_dalton
42223
uniprot
proteins
pathway_participation
PATHWAY: Sphingolipid metabolism. {ECO:0000250|UniProtKB:Q8NHU3}.
uniprot
proteins
post_translational_modification
PTM: Palmitoylated on Cys-331, Cys-332, Cys-343 and Cys-348; which plays an important role in plasma membrane localization. {ECO:0000250}.
uniprot
proteins
protein_family
Sphingomyelin synthase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17210739
uniprot
proteins
pubmed
21980337
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8NHU3}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8NHU3}; Multi-pass membrane protein {ECO:0000255}. Note=Primarily localized at the plasma membrane with a small fraction at the Golgi apparatus. {ECO:0000250|UniProtKB:Q8NHU3}.
uniprot
proteins
transmembrane_region
TRANSMEM 80..100; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 159..179; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 248..268; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 273..290; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins