CDC42SE1
entrez
56882
canonical
uniprot
Q9NRR8
canonical
ensembl
ENSG00000197622
resolver
ensp
ENSP00000349773
resolver
ensp
ENSP00000445647
resolver
ensp
ENSP00000589262
resolver
genesymbol
CDC42SE1
resolver
genesymbol_syn
SPEC1
resolver
hgnc
HGNC:17719
resolver
uniprot
D3DV12
resolver
uniprot
Q9HB17
resolver
uniprot
Q9NQR2
resolver
uniprot_entry
C42S1_HUMAN
resolver
uniprot_sec
D3DV12
resolver
uniprot_sec
Q9HB17
resolver
uniprot_sec
Q9NQR2
resolver
amino_acid_sequence
MSEFWHKLGCCVVEKPQPKKKRRRIDRTMIGEPMNFVHLTHIGSGEMGAGDGLAMTGAVQEQMRSKGNRDRPWSNSRGL
uniprot
proteins
function
FUNCTION: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. {ECO:0000269|PubMed:10816584, ECO:0000269|PubMed:15840583, ECO:0000269|PubMed:17045588}.
uniprot
proteins
mass_dalton
8925
uniprot
proteins
mutagenesis
MUTAGEN 10..11; /note="CC->AA: Prevents targeting to the activated TCR."; /evidence="ECO:0000269|PubMed:15840583"; MUTAGEN 33; /note="P->A: Abolishes interaction with CDC42, induces a decrease in blocking CDC42-induced JNK activation but does not affect targeting to the activated TCR; when associated with A-38 and A-41."; /evidence="ECO:0000269|PubMed:10816584, ECO:0000269|PubMed:15840583"; MUTAGEN 38; /note="H->A: Abolishes interaction with CDC42, induces a decrease in blocking CDC42-induced JNK activation but does not affect targeting to the activated TCR; when associated with A-33 and A-41."; /evidence="ECO:0000269|PubMed:10816584, ECO:0000269|PubMed:15840583"; MUTAGEN 41; /note="H->A: Abolishes interaction with CDC42, induces a decrease in blocking CDC42-induced JNK activation but does not affect targeting to the activated TCR; when associated with A-33 and A-38."; /evidence="ECO:0000269|PubMed:10816584, ECO:0000269|PubMed:15840583"; MUTAGEN 62; /note="Q->A: Abolishes interaction with CDC42 and induces a decrease in blocking CDC42-induced JNK activation; when associated with A-66."; /evidence="ECO:0000269|PubMed:10816584"; MUTAGEN 66; /note="K->A: Abolishes interaction with CDC42 and induces a decrease in blocking CDC42-induced JNK activation; when associated with A-62."; /evidence="ECO:0000269|PubMed:10816584
uniprot
proteins
protein_family
CDC42SE/SPEC family
uniprot
proteins
pubmed
10816584
uniprot
proteins
pubmed
11595176
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15840583
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17045588
uniprot
proteins
sequence_length
79
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Note=Recruited to the activated TCR prior actin polymerization.
uniprot
proteins