CALD1
entrez
800
canonical
uniprot
Q05682
canonical
ensembl
ENSG00000122786
resolver
ensp
ENSP00000354513
resolver
ensp
ENSP00000354826
resolver
ensp
ENSP00000376826
resolver
ensp
ENSP00000393621
resolver
ensp
ENSP00000395710
resolver
ensp
ENSP00000419673
resolver
ensp
ENSP00000536478
resolver
ensp
ENSP00000536479
resolver
ensp
ENSP00000536480
resolver
ensp
ENSP00000536481
resolver
ensp
ENSP00000536482
resolver
ensp
ENSP00000536483
resolver
ensp
ENSP00000536484
resolver
ensp
ENSP00000536487
resolver
ensp
ENSP00000597626
resolver
ensp
ENSP00000642465
resolver
ensp
ENSP00000642482
resolver
ensp
ENSP00000684336
resolver
ensp
ENSP00000684337
resolver
ensp
ENSP00000684338
resolver
ensp
ENSP00000684341
resolver
ensp
ENSP00000684342
resolver
enst
ENST00000495522
resolver
genesymbol
CALD1
resolver
genesymbol_syn
CAD
resolver
genesymbol_syn
CDM
resolver
hgnc
HGNC:1441
resolver
uniprot
A0A140VKA0
resolver
uniprot
A8K0X1
resolver
uniprot
E7EX44
resolver
uniprot
Q13978
resolver
uniprot
Q13979
resolver
uniprot
Q14741
resolver
uniprot
Q14742
resolver
uniprot
Q9UD91
resolver
uniprot_entry
A0A140VKA0_HUMAN
resolver
uniprot_entry
CALD1_HUMAN
resolver
uniprot_entry
E7EX44_HUMAN
resolver
uniprot_sec
A8K0X1
resolver
uniprot_sec
Q13978
resolver
uniprot_sec
Q13979
resolver
uniprot_sec
Q14741
resolver
uniprot_sec
Q14742
resolver
uniprot_sec
Q9UD91
resolver
amino_acid_sequence
MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKPSDLRPGDVSSKRNLWEKQSVDKVTSPTKV
uniprot
proteins
function
FUNCTION: Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}.
uniprot
proteins
mass_dalton
93231
uniprot
proteins
post_translational_modification
PTM: In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Caldesmon family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
1465449
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1555769
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
1885618
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
8227296
uniprot
proteins
sequence_length
793
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P13505}. Cytoplasm, myofibril {ECO:0000250|UniProtKB:P13505}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:P13505}. Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle). {ECO:0000250|UniProtKB:P13505}.
uniprot
proteins