Kcnh5
entrez
171146
canonical
uniprot
Q9EPI9
canonical
ensembl
ENSRNOG00000009542
resolver
ensembl
ENSRNOG00055020005
resolver
ensembl
ENSRNOG00060028143
resolver
ensembl
ENSRNOG00065018672
resolver
ensp
ENSRNOP00000013275
resolver
ensp
ENSRNOP00055027711
resolver
ensp
ENSRNOP00060040815
resolver
ensp
ENSRNOP00065024983
resolver
enst
ENSRNOT00000013275
resolver
enst
ENSRNOT00055034161
resolver
enst
ENSRNOT00060048912
resolver
enst
ENSRNOT00065031354
resolver
genesymbol
Kcnh5
resolver
genesymbol_syn
Eag2
resolver
uniprot
O88893
resolver
uniprot
Q9QXT2
resolver
uniprot_entry
KCNH5_RAT
resolver
uniprot_sec
O88893
resolver
uniprot_sec
Q9QXT2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by low nanomolar concentrations of cytosolic calcium. {ECO:0000269|PubMed:10882483}.
uniprot
proteins
amino_acid_sequence
MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTETVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDEEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSAQSDPERSQLQVESRPLQNGASITGTSVVTVSQITPIQTSLAYVKTSETLKQNNRDAMELKPNGGAEPKCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKEEWNNVTKAESMGLLSEDPKGSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPSQADAKHPFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKLLSEKSVPQTSSPKPQIPLQVPPQIPCQDIFSVSRPESPESDKDEINF
uniprot
proteins
function
FUNCTION: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate (PubMed:10594062, PubMed:10882483). The kinetic is characterized by a slow activation time course and a small voltage dependence of the activation time constants, therefore, starts to open at more negative voltages (PubMed:10594062, PubMed:10882483). The activation kinetics depend on the prepulse potential and external divalent cation concentration (PubMed:10594062, PubMed:10882483). The time course of activation is biphasic with a fast and a slowly activating current component (PubMed:10594062, PubMed:10882483). With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation, therefore the activation rate depends on holding potential (PubMed:10594062, PubMed:10882483). {ECO:0000269|PubMed:10594062, ECO:0000269|PubMed:10882483}.
uniprot
proteins
mass_dalton
111830
uniprot
proteins
protein_family
H (Eag) (TC 1.A.1.20) subfamily
uniprot
proteins
protein_family
Kv10.2/KCNH5 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10594062
uniprot
proteins
pubmed
10882483
uniprot
proteins
pubmed
9714851
uniprot
proteins
sequence_length
988
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 218..238; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 244..264; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 292..312; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 320..340; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 347..367; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 447..467; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins