Klhdc3
entrez
363192
canonical
uniprot
Q6AYI2
canonical
ensembl
ENSRNOG00000017495
resolver
ensembl
ENSRNOG00055008685
resolver
ensembl
ENSRNOG00060023951
resolver
ensembl
ENSRNOG00065027045
resolver
ensp
ENSRNOP00000109956
resolver
ensp
ENSRNOP00055011747
resolver
ensp
ENSRNOP00060034430
resolver
ensp
ENSRNOP00065038266
resolver
enst
ENSRNOT00000167647
resolver
enst
ENSRNOT00055014683
resolver
enst
ENSRNOT00060041551
resolver
enst
ENSRNOT00065046664
resolver
genesymbol
Klhdc3
resolver
uniprot_entry
KLDC3_RAT
resolver
amino_acid_sequence
MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVRPAVRGQAPVVPYMRYGHSTVLIDDTVFLWGGRNDTEGACNVLYAFDVNTHKWSTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQLADCFSNDIHKLDTSTMTWTLVCTKGNPARWRDFHSATMLGNHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPHTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPGSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons. The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine. May be involved in meiotic recombination process. {ECO:0000250|UniProtKB:Q9BQ90}.
uniprot
proteins
mass_dalton
43109
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9BQ90}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BQ90}.
uniprot
proteins