Bcat2
entrez
12036
canonical
uniprot
O35855
canonical
ensembl
ENSMUSG00000030826
resolver
ensp
ENSMUSP00000033098
resolver
ensp
ENSMUSP00000147628
resolver
ensp
ENSMUSP00000148152
resolver
ensp
ENSMUSP00000223277
resolver
ensp
ENSMUSP00000326697
resolver
enst
ENSMUST00000033098
resolver
enst
ENSMUST00000209204
resolver
enst
ENSMUST00000211173
resolver
genesymbol
Bcat2
resolver
genesymbol_syn
Bcatm
resolver
genesymbol_syn
Eca40
resolver
uniprot
A0A1B0GT11
resolver
uniprot
D3Z7C8
resolver
uniprot
O88374
resolver
uniprot
Q3ULU3
resolver
uniprot
Q8VD03
resolver
uniprot_entry
A0A1B0GT11_MOUSE
resolver
uniprot_entry
BCAT2_MOUSE
resolver
uniprot_entry
O88374_MOUSE
resolver
uniprot_entry
Q3ULU3_MOUSE
resolver
uniprot_sec
D3Z7C8
resolver
uniprot_sec
Q8VD03
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by telmisartan, promoting adipose tissue browning and protecting against obesity. {ECO:0000269|PubMed:35075301}.
uniprot
proteins
amino_acid_sequence
MAAATLGQVWARKLLPVPWLLCGSKRCVSSIFKAADLQIQMTKEPQKKPAPSQALLFGKTFTDHMLMVEWNNKAGWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEVDKDWVPDGNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPGDSMTPVSLLADPSFVRAWIGGVGDCKLGGNYGPTVAVQREAQKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDLARTWGEFRVAERKVTMKELKRALEEGRVREVFGSGTACQVCPVHQILYEGKQLHIPTMENGPELILRFQKELKAIQYGASAHDWMFRV
uniprot
proteins
ec_number
2.6.1.42
uniprot
proteins
function
FUNCTION: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine (PubMed:14755340, PubMed:17767905). Branched chain amino acid catabolism plays a role in adipocyte differentiation by providing lipogenic acetyl-CoA pools in differentiated adipocytes (PubMed:17767905, PubMed:35075301). Mechanistically, acetyl-CoA derived from branched chain amino acid catabolism is used by EP300/p300 to acetylate and inhibit PRDM16, thereby preventing adipose tissue browning (PubMed:35075301). May also function as a transporter of branched chain alpha-keto acids (By similarity). {ECO:0000250|UniProtKB:O35854, ECO:0000269|PubMed:14755340, ECO:0000269|PubMed:17767905, ECO:0000269|PubMed:35075301}.
uniprot
proteins
mass_dalton
44127
uniprot
proteins
protein_family
Class-IV pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
14755340
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17767905
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
35075301
uniprot
proteins
pubmed
9165094
uniprot
proteins
sequence_length
393
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14755340}.
uniprot
proteins