PDE4D
entrez
5144
canonical
uniprot
Q08499
canonical
ensembl
ENSG00000113448
resolver
ensp
ENSP00000321739
resolver
ensp
ENSP00000345502
resolver
ensp
ENSP00000351800
resolver
ensp
ENSP00000353152
resolver
ensp
ENSP00000384806
resolver
ensp
ENSP00000423094
resolver
ensp
ENSP00000424852
resolver
ensp
ENSP00000425605
resolver
ensp
ENSP00000425917
resolver
ensp
ENSP00000490821
resolver
enst
ENST00000636120
resolver
genesymbol
PDE4D
resolver
genesymbol_syn
DPDE3
resolver
hgnc
HGNC:8783
resolver
uniprot
A0A140VJR0
resolver
uniprot
A0A1B0GW84
resolver
uniprot
O43433
resolver
uniprot
Q13549
resolver
uniprot
Q13550
resolver
uniprot
Q13551
resolver
uniprot
Q7Z2L8
resolver
uniprot
Q8IV84
resolver
uniprot
Q8IVA9
resolver
uniprot
Q8IVD2
resolver
uniprot
Q8IVD3
resolver
uniprot
Q96HL4
resolver
uniprot
Q9HCX7
resolver
uniprot_entry
A0A140VJR0_HUMAN
resolver
uniprot_entry
A0A1B0GW84_HUMAN
resolver
uniprot_entry
PDE4D_HUMAN
resolver
uniprot_sec
O43433
resolver
uniprot_sec
Q13549
resolver
uniprot_sec
Q13550
resolver
uniprot_sec
Q13551
resolver
uniprot_sec
Q7Z2L8
resolver
uniprot_sec
Q8IV84
resolver
uniprot_sec
Q8IVA9
resolver
uniprot_sec
Q8IVD2
resolver
uniprot_sec
Q8IVD3
resolver
uniprot_sec
Q96HL4
resolver
uniprot_sec
Q9HCX7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by rolipram. Activated by phosphatidic acid. {ECO:0000269|PubMed:15131123}.
uniprot
proteins
amino_acid_sequence
MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
uniprot
proteins
disease_involvement
DISEASE: Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution. {ECO:0000269|PubMed:17006457}.; DISEASE: Acrodysostosis 2, with or without hormone resistance (ACRDYS2) [MIM:614613]: A pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems. {ECO:0000269|PubMed:22464250, ECO:0000269|PubMed:22464252, ECO:0000269|PubMed:23033274, ECO:0000269|PubMed:23043190}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.4.53
uniprot
proteins
function
FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}.
uniprot
proteins
mass_dalton
91115
uniprot
proteins
mutagenesis
MUTAGEN 503; /note="D->N: Decreased 3',5'-cyclic-AMP phosphodiesterase activity. Loss of Mg2(+)-binding."; /evidence="ECO:0000269|PubMed:17582435"; MUTAGEN 527; /note="D->R: Abolishes homodimerization."; /evidence="ECO:0000269|PubMed:12387865"; MUTAGEN 563; /note="R->D: Abolishes homodimerization."; /evidence="ECO:0000269|PubMed:12387865
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. {ECO:0000269|PubMed:9371713}.
uniprot
proteins
post_translational_modification
PTM: Long isoforms that share a conserved PKA phosphorylation site in the N-terminus are activated by PKA through phosphorylation (By similarity). Isoform 3 and isoform 7 are activated by phosphorylation (in vitro), but not isoform 6. Isoform N3 and isoform 12 are phosphorylated on Ser-49, Ser-51, Ser-55 and Ser-59. {ECO:0000250}.; PTM: Sumoylation of long isoforms by PIAS4 augments their activation by PKA phosphorylation and represses their inhibition by ERK phosphorylation. {ECO:0000269|PubMed:20196770}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE4 subfamily
uniprot
proteins
pubmed
10913353
uniprot
proteins
pubmed
12193273
uniprot
proteins
pubmed
12387865
uniprot
proteins
pubmed
12834813
uniprot
proteins
pubmed
12842049
uniprot
proteins
pubmed
14500724
uniprot
proteins
pubmed
14517540
uniprot
proteins
pubmed
14609333
uniprot
proteins
pubmed
14668322
uniprot
proteins
pubmed
15003452
uniprot
proteins
pubmed
15131123
uniprot
proteins
pubmed
15260978
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15576036
uniprot
proteins
pubmed
15685167
uniprot
proteins
pubmed
16539372
uniprot
proteins
pubmed
17006457
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17244609
uniprot
proteins
pubmed
17519386
uniprot
proteins
pubmed
17582435
uniprot
proteins
pubmed
17727341
uniprot
proteins
pubmed
17900862
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20196770
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22464250
uniprot
proteins
pubmed
22464252
uniprot
proteins
pubmed
23033274
uniprot
proteins
pubmed
23043190
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
8125310
uniprot
proteins
pubmed
8413254
uniprot
proteins
pubmed
8797812
uniprot
proteins
pubmed
9371713
uniprot
proteins
sequence_length
809
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:14500724}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity). Colocalized with SHANK2 to the apical membrane of colonic crypt cells. {ECO:0000250}.
uniprot
proteins