Arf1
entrez
64310
canonical
uniprot
P84079
canonical
ensembl
ENSRNOG00055029680
resolver
ensembl
ENSRNOG00060030926
resolver
ensembl
ENSRNOG00065007676
resolver
ensp
ENSRNOP00055042364
resolver
ensp
ENSRNOP00060044568
resolver
ensp
ENSRNOP00065008774
resolver
enst
ENSRNOT00055051399
resolver
enst
ENSRNOT00060053692
resolver
enst
ENSRNOT00065012012
resolver
genesymbol
Arf1
resolver
uniprot
P10947
resolver
uniprot
P32889
resolver
uniprot_entry
ARF1_RAT
resolver
uniprot_sec
P10947
resolver
uniprot_sec
P32889
resolver
activity_regulation
ACTIVITY REGULATION: Alternates between an inactive GDP-bound form and an active GTP-bound form (By similarity). Activated by guanine nucleotide-exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs) (By similarity). {ECO:0000250|UniProtKB:P84077}.
uniprot
proteins
amino_acid_sequence
MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQK
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Small GTPase involved in protein trafficking between different compartments (By similarity). Modulates vesicle budding and uncoating within the Golgi complex (By similarity). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (PubMed:23889934). Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis (By similarity). Also plays a critical role in mast cell expansion but not in mast cell maturation by facilitating optimal mTORC1 activation (By similarity). {ECO:0000250|UniProtKB:P84077, ECO:0000269|PubMed:23889934}.
uniprot
proteins
mass_dalton
20697
uniprot
proteins
protein_family
Arf family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10022920
uniprot
proteins
pubmed
10623590
uniprot
proteins
pubmed
10747863
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23889934
uniprot
proteins
pubmed
7552752
uniprot
proteins
pubmed
7890632
uniprot
proteins
pubmed
8813705
uniprot
proteins
sequence_length
181
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:23889934}; Lipid-anchor {ECO:0000250|UniProtKB:P84080}; Cytoplasmic side {ECO:0000305}. Synapse, synaptosome {ECO:0000269|PubMed:23889934}. Postsynaptic density {ECO:0000269|PubMed:23889934}. Note=In the GDP-bound form, associates transiently with the membranes via its myristoylated N-terminus where guanine nucleotide-exchange factor (GEF)-mediated nucleotide exchange occurs (By similarity). Following nucleotide exchange, the GTP-bound form undergoes a conformational change, leading to the exposure of a myristoylated N-terminal amphipathic helix that provides stable membrane anchorage (By similarity). {ECO:0000250|UniProtKB:P84080}.
uniprot
proteins