Necap1
entrez
67602
canonical
uniprot
Q9CR95
canonical
ensembl
ENSMUSG00000030327
resolver
ensp
ENSMUSP00000032477
resolver
enst
ENSMUST00000032477
resolver
genesymbol
Necap1
resolver
uniprot
Q0VB06
resolver
uniprot
Q3TH13
resolver
uniprot
Q78JW3
resolver
uniprot
Q8C4P1
resolver
uniprot_entry
NECP1_MOUSE
resolver
uniprot_entry
Q0VB06_MOUSE
resolver
uniprot_sec
Q3TH13
resolver
uniprot_sec
Q78JW3
resolver
uniprot_sec
Q8C4P1
resolver
amino_acid_sequence
MAAELEYESVLCVKPDVSVYRIPPRASNRGYRASDWKLDQPDWTGRLRITSKGKIAYIKLEDKVSGELFAQAPVEQYPGIAVETVTDSSRYFVIRIQDGTGRSAFIGIGFTDRGDAFDFNVSLQDHFKWVKQETEISKESQEMDNRPKLDLGFKEGQTIKLSIGNITAKKGGASKPRASGTGGLSLLPPPPGGKVTIPPPSSSVAISNHVTPPPIPKSNHGGNDSDILLDLDSPAPVSTSAPAPVSTSNDLWGDFSTASSSVPNQAPQPSNWVQF
uniprot
proteins
function
FUNCTION: Involved in endocytosis. {ECO:0000250, ECO:0000269|PubMed:14555962}.
uniprot
proteins
mass_dalton
29639
uniprot
proteins
mutagenesis
MUTAGEN 270; /note="S->D: Loss of binding to AP-2 and can bind to AP-1; when associated with G-273."; MUTAGEN 272; /note="W->A,F,Y: Loss of binding to AP-2."; /evidence="ECO:0000269|PubMed:15359277"; MUTAGEN 273; /note="V->A,D,E,I: No effect on binding to AP-2."; /evidence="ECO:0000269|PubMed:15359277"; MUTAGEN 273; /note="V->G: Loss of binding to AP-2 and can bind to AP-1; when associated with D-270."; /evidence="ECO:0000269|PubMed:15359277"; MUTAGEN 273; /note="V->L,N,P,S: Loss of binding to AP-2."; /evidence="ECO:0000269|PubMed:15359277"; MUTAGEN 274; /note="Q->A,M,N,S,T: No effect on binding to AP-2."; /evidence="ECO:0000269|PubMed:15359277"; MUTAGEN 275; /note="F->A,F,Y: Loss of binding to AP-2."; /evidence="ECO:0000269|PubMed:15359277"; MUTAGEN 275; /note="F->W: No effect on binding to AP-2."; /evidence="ECO:0000269|PubMed:15359277
uniprot
proteins
protein_family
NECAP family
uniprot
proteins
pubmed
14555962
uniprot
proteins
pubmed
14665628
uniprot
proteins
pubmed
15359277
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24399846
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:14555962}. Cell membrane {ECO:0000269|PubMed:14555962}. Note=Colocalizes with AP-2 at the plasma membrane.
uniprot
proteins