Magi2
entrez
50791
canonical
uniprot
Q9WVQ1
canonical
ensembl
ENSMUSG00000040003
resolver
ensp
ENSMUSP00000085872
resolver
ensp
ENSMUSP00000099094
resolver
ensp
ENSMUSP00000110922
resolver
ensp
ENSMUSP00000142576
resolver
ensp
ENSMUSP00000142764
resolver
ensp
ENSMUSP00000146769
resolver
ensp
ENSMUSP00000287417
resolver
ensp
ENSMUSP00000287420
resolver
enst
ENSMUST00000197354
resolver
enst
ENSMUST00000197443
resolver
genesymbol
Magi2
resolver
genesymbol_syn
Acvrinp1
resolver
genesymbol_syn
Aip1
resolver
genesymbol_syn
Arip1
resolver
uniprot
A0A0G2JE00
resolver
uniprot
A0A0G2JEG6
resolver
uniprot
Q3UH81
resolver
uniprot
Q6GT88
resolver
uniprot
Q8BYT1
resolver
uniprot
Q8CA85
resolver
uniprot_entry
A0A0G2JE00_MOUSE
resolver
uniprot_entry
A0A0G2JEG6_MOUSE
resolver
uniprot_entry
MAGI2_MOUSE
resolver
uniprot_sec
Q3UH81
resolver
uniprot_sec
Q6GT88
resolver
uniprot_sec
Q8BYT1
resolver
uniprot_sec
Q8CA85
resolver
amino_acid_sequence
MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEEFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLNVTDQILPGATPSAEGKRKRNKSVTNMEKASIEPPEEEEEERPVVNGNGVVITPESSEHEDKSAGASGETPSQPYPAPVYSQPEELKDQMDDTKPTKPEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGAKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPADGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPVGSETSLIIHRGGFFSPWKTPKPMMDRWENQGSPQTSLSAPAVPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYSNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGATITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQHSPLAQQSPLAQPSPATPNSPVAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYSQPPPLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTTNPTPGVLPLPPPQACRK
uniprot
proteins
function
FUNCTION: Seems to act as a scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins (By similarity). Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth (By similarity). May play a role in regulating activin-mediated signaling in neuronal cells (PubMed:10681527). Enhances the ability of PTEN to suppress AKT1 activation (By similarity). Plays a role in receptor-mediated clathrin-dependent endocytosis which is required for ciliogenesis (PubMed:24608321). {ECO:0000250|UniProtKB:O88382, ECO:0000250|UniProtKB:Q86UL8, ECO:0000269|PubMed:10681527, ECO:0000269|PubMed:24608321}.
uniprot
proteins
mass_dalton
140919
uniprot
proteins
mutagenesis
MUTAGEN 1152; /note="S->A: Does not affect interaction with USH1G."; /evidence="ECO:0000269|PubMed:24608321
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
10681527
uniprot
proteins
pubmed
14988405
uniprot
proteins
pubmed
15340156
uniprot
proteins
pubmed
15466885
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15509766
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23751499
uniprot
proteins
pubmed
24608321
uniprot
proteins
sequence_length
1275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Late endosome {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24608321}. Cell projection, cilium {ECO:0000269|PubMed:24608321}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:24608321}. Photoreceptor inner segment {ECO:0000269|PubMed:24608321}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:24608321}. Note=Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity). {ECO:0000250}.
uniprot
proteins