TSPAN4
entrez
7106
canonical
uniprot
O14817
canonical
ensembl
ENSG00000214063
resolver
ensp
ENSP00000380551
resolver
ensp
ENSP00000380552
resolver
ensp
ENSP00000380553
resolver
ensp
ENSP00000380554
resolver
ensp
ENSP00000380555
resolver
ensp
ENSP00000380558
resolver
ensp
ENSP00000386513
resolver
ensp
ENSP00000431943
resolver
ensp
ENSP00000436260
resolver
ensp
ENSP00000564521
resolver
ensp
ENSP00000564522
resolver
ensp
ENSP00000564524
resolver
ensp
ENSP00000564528
resolver
ensp
ENSP00000564531
resolver
ensp
ENSP00000564532
resolver
ensp
ENSP00000564533
resolver
ensp
ENSP00000564535
resolver
ensp
ENSP00000564536
resolver
ensp
ENSP00000564537
resolver
ensp
ENSP00000564538
resolver
ensp
ENSP00000564543
resolver
ensp
ENSP00000564546
resolver
ensp
ENSP00000582227
resolver
ensp
ENSP00000582228
resolver
ensp
ENSP00000582232
resolver
ensp
ENSP00000582233
resolver
ensp
ENSP00000582234
resolver
ensp
ENSP00000582235
resolver
ensp
ENSP00000582236
resolver
ensp
ENSP00000641932
resolver
ensp
ENSP00000641933
resolver
ensp
ENSP00000641934
resolver
ensp
ENSP00000641937
resolver
ensp
ENSP00000641938
resolver
ensp
ENSP00000641940
resolver
ensp
ENSP00000641944
resolver
ensp
ENSP00000641946
resolver
enst
ENST00000397396
resolver
enst
ENST00000397397
resolver
enst
ENST00000397404
resolver
enst
ENST00000397406
resolver
enst
ENST00000397408
resolver
enst
ENST00000397411
resolver
enst
ENST00000409543
resolver
enst
ENST00000525201
resolver
enst
ENST00000527644
resolver
enst
ENST00000894462
resolver
enst
ENST00000894463
resolver
enst
ENST00000894465
resolver
enst
ENST00000894469
resolver
enst
ENST00000894473
resolver
enst
ENST00000894474
resolver
enst
ENST00000894476
resolver
enst
ENST00000894477
resolver
enst
ENST00000894478
resolver
enst
ENST00000894479
resolver
enst
ENST00000894484
resolver
enst
ENST00000894487
resolver
enst
ENST00000912168
resolver
enst
ENST00000912169
resolver
enst
ENST00000912173
resolver
enst
ENST00000912174
resolver
enst
ENST00000912175
resolver
enst
ENST00000912176
resolver
enst
ENST00000912177
resolver
enst
ENST00000971873
resolver
enst
ENST00000971874
resolver
enst
ENST00000971875
resolver
enst
ENST00000971878
resolver
enst
ENST00000971879
resolver
enst
ENST00000971881
resolver
enst
ENST00000971885
resolver
enst
ENST00000971887
resolver
genesymbol
TSPAN4
resolver
genesymbol_syn
NAG2
resolver
genesymbol_syn
TM4SF7
resolver
hgnc
HGNC:11859
resolver
uniprot
A8MVV6
resolver
uniprot
B7WPM8
resolver
uniprot
E9PPX8
resolver
uniprot
Q6IAP6
resolver
uniprot_entry
A8MVV6_HUMAN
resolver
uniprot_entry
E9PPX8_HUMAN
resolver
uniprot_entry
TSN4_HUMAN
resolver
uniprot_sec
B7WPM8
resolver
uniprot_sec
Q6IAP6
resolver
amino_acid_sequence
MARACLQAVKYLMFAFNLLFWLGGCGVLGVGIWLAATQGSFATLSSSFPSLSAANLLIITGAFVMAIGFVGCLGAIKENKCLLLTFFLLLLLVFLLEATIAILFFAYTDKIDRYAQQDLKKGLHLYGTQGNVGLTNAWSIIQTDFRCCGVSNYTDWFEVYNATRVPDSCCLEFSESCGLHAPGTWWKAPCYETVKVWLQENLLAVGIFGLCTALVQILGLTFAMTMYCQVVKADTYCA
uniprot
proteins
function
FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays an essential role in migrasome formation and migration on retracting fibers at the rear end of migrating cells (PubMed:31371828). Migrasomes are cellular organelles that form as large vesicle-like structures on retraction fibers of migrating cells (PubMed:31371828). Mechanistically, acts as a membrane curvature sensor and participates in stabilizing the migrasome structure in a late stage of biogenesis (PubMed:36252000, PubMed:36823145). May also play a regulatory role for the histamine H4 receptor/HRH4 without affecting histamine binding to HRH4 or signaling (PubMed:34439793). {ECO:0000269|PubMed:31371828, ECO:0000269|PubMed:34439793, ECO:0000269|PubMed:36252000, ECO:0000269|PubMed:36823145}.
uniprot
proteins
mass_dalton
26118
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
25342562
uniprot
proteins
pubmed
31371828
uniprot
proteins
pubmed
34439793
uniprot
proteins
pubmed
36252000
uniprot
proteins
pubmed
36823145
uniprot
proteins
pubmed
9360996
uniprot
proteins
pubmed
9714763
uniprot
proteins
sequence_length
238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25342562, ECO:0000269|PubMed:34439793}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 14..34; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 56..76; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 86..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins