Ttc4
entrez
72354
canonical
uniprot
Q8R3H9
canonical
ensembl
ENSMUSG00000025413
resolver
ensp
ENSMUSP00000026480
resolver
enst
ENSMUST00000026480
resolver
genesymbol
Ttc4
resolver
uniprot
Q3UZC4
resolver
uniprot
Q9CSK1
resolver
uniprot_entry
CNS1_MOUSE
resolver
uniprot_entry
Q3UZC4_MOUSE
resolver
uniprot_entry
Q9CSK1_MOUSE
resolver
amino_acid_sequence
MESSEPEPTEDASMDAFLEKFQSQPYRGGFREDQWEEEFDKIPLFMKKAPSEIDPEEFPDLACLQSMIFDDDRYPEEQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKKKCADPDLNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAIIRGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEIRAKADKLKRMEERDLRKAKLKEKKEQHQNEALLQAIKARNIRLVSESAGEDEDSASNGPAEILLDGLSSENPYGARLSIDDQGRLSWPVLFLYPEYAQSDFISAFHEDTRFIDHLMAMFSEAPSWDSEHKYHPENLEVYFEDEDRAELYQVSPDSTLLQVLQHPRCCVKALTPAFLVCVGSSPFCRNYLQGKKVHR
uniprot
proteins
function
FUNCTION: Co-chaperone that recruits molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1) to nascent polypeptides, facilitating their proper folding into functional proteins (By similarity). Client proteins include eukaryotic elongation factor eEF2, a key player in cellular translation. Stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity (By similarity). {ECO:0000250|UniProtKB:O95801, ECO:0000250|UniProtKB:P33313}.
uniprot
proteins
mass_dalton
44339
uniprot
proteins
protein_family
TTC4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17335777
uniprot
proteins
pubmed
19390865
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24913909
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17335777, ECO:0000269|PubMed:19390865, ECO:0000269|PubMed:24913909}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:O95801}. Cytoplasm {ECO:0000269|PubMed:19390865}. Note=Predominantly nuclear in the G1 and S phases of cell cycle and is evenly distributed between the nucleus and cytoplasm in the G2 phase (PubMed:19390865). MSL1 can promote its nuclear localization (PubMed:19390865, PubMed:24913909). {ECO:0000269|PubMed:19390865, ECO:0000269|PubMed:24913909}.
uniprot
proteins