RHPN2
entrez
85415
canonical
uniprot
Q8IUC4
canonical
ensembl
ENSG00000131941
resolver
ensp
ENSP00000254260
resolver
genesymbol
RHPN2
resolver
hgnc
HGNC:19974
resolver
uniprot
B2RCG8
resolver
uniprot
B3KUY8
resolver
uniprot
B4DUS7
resolver
uniprot
Q8N3T7
resolver
uniprot
Q8N9D6
resolver
uniprot
Q8NE33
resolver
uniprot
Q96RU1
resolver
uniprot_entry
RHPN2_HUMAN
resolver
uniprot_sec
B2RCG8
resolver
uniprot_sec
B3KUY8
resolver
uniprot_sec
B4DUS7
resolver
uniprot_sec
Q8N3T7
resolver
uniprot_sec
Q8N9D6
resolver
uniprot_sec
Q8NE33
resolver
uniprot_sec
Q96RU1
resolver
amino_acid_sequence
MTDALLPAAPQPLEKENDGYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLKVATNSKVREQVRLELSFVNSDLQMLKEELEGLNISVGVYQNTEEAFTIPLIPLGLKETKDVDFAVVLKDFILEHYSEDGYLYEDEIADLMDLRQACRTPSRDEAGVELLMTYFIQLGFVESRFFPPTRQMGLLFTWYDSLTGVPVSQQNLLLEKASVLFNTGALYTQIGTRCDRQTQAGLESAIDAFQRAAGVLNYLKDTFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEKISLPGIRNEFFMLVKVAQEAAKVGEVYQQLHAAMSQAPVKENIPYSWASLACVKAHHYAALAHYFTAILLIDHQVKPGTDLDHQEKCLSQLYDHMPEGLTPLATLKNDQQRRQLGKSHLRRAMAHHEESVREASLCKKLRSIEVLQKVLCAAQERSRLTYAQHQEEDDLLNLIDAPSVVAKTEQEVDIILPQFSKLTVTDFFQKLGPLSVFSANKRWTPPRSIRFTAEEGDLGFTLRGNAPVQVHFLDPYCSASVAGAREGDYIVSIQLVDCKWLTLSEVMKLLKSFGEDEIEMKVVSLLDSTSSMHNKSATYSVGMQKTYSMICLAIDDDDKTDKTKKISKKLSFLSWGTNKNRQKSASTLCLPSVGAARPQVKKKLPSPFSLLNSDSSWY
uniprot
proteins
function
FUNCTION: Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}.
uniprot
proteins
mass_dalton
76993
uniprot
proteins
mutagenesis
MUTAGEN 58..59; /note="EN->AA: Abolishes interaction with RhoA."; /evidence="ECO:0000269|PubMed:12221077"; MUTAGEN 518; /note="R->A: Does not induce actin disassembly but still interacts with RhoA; when associated with A-526 and A-527."; /evidence="ECO:0000269|PubMed:12221077"; MUTAGEN 526..527; /note="LG->AA: Does not induce actin disassembly but still interacts with RhoA; when associated with A-518."; /evidence="ECO:0000269|PubMed:12221077
uniprot
proteins
protein_family
RHPN family
uniprot
proteins
pubmed
12221077
uniprot
proteins
pubmed
12473120
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
686
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12473120}.
uniprot
proteins