Tgfbr3
entrez
29610
canonical
uniprot
P26342
canonical
ensembl
ENSRNOG00000002093
resolver
ensembl
ENSRNOG00055024620
resolver
ensembl
ENSRNOG00060010131
resolver
ensembl
ENSRNOG00065013029
resolver
ensp
ENSRNOP00000002867
resolver
ensp
ENSRNOP00000101933
resolver
ensp
ENSRNOP00055034608
resolver
ensp
ENSRNOP00060013297
resolver
ensp
ENSRNOP00065016513
resolver
enst
ENSRNOT00000002867
resolver
enst
ENSRNOT00000158257
resolver
enst
ENSRNOT00055042376
resolver
enst
ENSRNOT00060017107
resolver
enst
ENSRNOT00065021353
resolver
genesymbol
Tgfbr3
resolver
uniprot
A0ABK0LF96
resolver
uniprot_entry
A0ABK0LF96_RAT
resolver
uniprot_entry
TGBR3_RAT
resolver
amino_acid_sequence
MAVTSHHMIPVMVVLMSACLATAGPEPSTRCELSPINASHPVQALMESFTVLSGCASRGTTGLPREVHVLNLRSTDQGPGQRQREVTLHLNPIASVHTHHKPIVFLLNSPQPLVWHLKTERLAAGVPRLFLVSEGSVVQFPSGNFSLTAETEERNFPQENEHLLRWAQKEYGAVTSFTELKIARNIYIKVGEDQVFPPTCNIGKNFLSLNYLAEYLQPKAAEGCVLPSQPHEKEVHIIELITPSSNPYSAFQVDIIVDIRPAQEDPEVVKNLVLILKCKKSVNWVIKSFDVKGNLKVIAPNSIGFGKESERSMTMTKLVRDDIPSTQENLMKWALDNGYRPVTSYTMAPVANRFHLRLENNEEMRDEEVHTIPPELRILLDPDHPPALDNPLFPGEGSPNGGLPFPFPDIPRRGWKEGEDRIPRPKQPIVPSVQLLPDHREPEEVQGGVDIALSVKCDHEKMVVAVDKDSFQTNGYSGMELTLLDPSCKAKMNGTHFVLESPLNGCGTRHRRSTPDGVVYYNSIVVQAPSPGDSSGWPDGYEDLESGDNGFPGDGDEGETAPLSRAGVVVFNCSLRQLRNPSGFQGQLDGNATFNMELYNTDLFLVPSPGVFSVAENEHVYVEVSVTKADQDLGFAIQTCFLSPYSNPDRMSDYTIIENICPKDDSVKFYSSKRVHFPIPHAEVDKKRFSFLFKSVFNTSLLFLHCELTLCSRKKGSLKLPRCVTPDDACTSLDATMIWTMMQNKKTFTKPLAVVLQVDYKENVPSTKDSSPIPPPPPQIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETARRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA
uniprot
proteins
function
FUNCTION: Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5. Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B (By similarity). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (By similarity). Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization (By similarity). Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway (By similarity). {ECO:0000250|UniProtKB:Q03167, ECO:0000269|PubMed:21402931}.
uniprot
proteins
mass_dalton
94103
uniprot
proteins
post_translational_modification
PTM: Extensively modified by glycosaminoglycan groups (GAG). {ECO:0000250|UniProtKB:Q03167}.; PTM: Phosphorylated in the cytoplasmic domain by the type II receptor TGFBR2 at THR-842 to mediate recruitment of ARRB2 and subsequent internalization of TGFBR2 and TGFBR3. {ECO:0000250|UniProtKB:Q03167}.
uniprot
proteins
pubmed
1657406
uniprot
proteins
pubmed
1657407
uniprot
proteins
pubmed
21402931
uniprot
proteins
sequence_length
853
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:1657406}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:1657406}. Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:1657406}. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix. {ECO:0000305|PubMed:1657406}.
uniprot
proteins
transmembrane_region
TRANSMEM 790..811; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins