Gdf11
entrez
29454
canonical
uniprot
Q9Z217
canonical
ensembl
ENSRNOG00000007610
resolver
ensembl
ENSRNOG00055014477
resolver
ensembl
ENSRNOG00060027537
resolver
ensembl
ENSRNOG00065013036
resolver
ensp
ENSRNOP00000010035
resolver
ensp
ENSRNOP00055020296
resolver
ensp
ENSRNOP00060039719
resolver
ensp
ENSRNOP00065016526
resolver
enst
ENSRNOT00000010035
resolver
enst
ENSRNOT00055024841
resolver
enst
ENSRNOT00060047757
resolver
enst
ENSRNOT00065021368
resolver
genesymbol
Gdf11
resolver
genesymbol_syn
Bmp11
resolver
uniprot
G3V6Y2
resolver
uniprot_entry
GDF11_RAT
resolver
uniprot_sec
G3V6Y2
resolver
amino_acid_sequence
MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAGVGGERSSRPAPSAAPEPDGCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS
uniprot
proteins
function
FUNCTION: Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3. {ECO:0000250|UniProtKB:O95390, ECO:0000250|UniProtKB:Q9Z1W4}.
uniprot
proteins
mass_dalton
44921
uniprot
proteins
post_translational_modification
PTM: Synthesized as large precursor molecule that undergoes proteolytic cleavage by furin-like proteases. This produces an inactive form consisting of the mature C-terminal portion non-covalently bound to its cleaved N-terminal propeptide. Activation of the mature form requires additional cleavage of the propeptide by a tolloid-like metalloproteinase. {ECO:0000250|UniProtKB:Q9Z1W4}.
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
10072786
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
405
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins