CFAP100
entrez
348807
canonical
uniprot
Q494V2
canonical
ensembl
ENSG00000163885
resolver
ensp
ENSP00000344749
resolver
genesymbol
CFAP100
resolver
genesymbol_syn
CCDC37
resolver
hgnc
HGNC:26842
resolver
uniprot
D3DNA8
resolver
uniprot
Q494V1
resolver
uniprot
Q494V4
resolver
uniprot
Q8N838
resolver
uniprot_entry
CP100_HUMAN
resolver
uniprot_sec
D3DNA8
resolver
uniprot_sec
Q494V1
resolver
uniprot_sec
Q494V4
resolver
uniprot_sec
Q8N838
resolver
amino_acid_sequence
MSEIPSTIVSKNMTNDKNSLESMNISSSSSTEENPKKQARKNEEHGPDPSANPFHLSGDVDFFLLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEELLFFFT
uniprot
proteins
function
FUNCTION: Microtubule-associated protein that promotes microtubule polymerization and regulates microtubule organization (PubMed:37192300). Plays a critical role in ensuring proper epidermal development and function by regulating mitosis in keratinocytes (PubMed:40593606). Maintains spindle pole integrity during keratinocyte division through the recruitment of the microtubule glutamylase TTLL13 to spindle poles, thereby enhancing localized microtubule glutamylation (PubMed:40593606). This modification stabilizes spindle microtubules, ensuring accurate spindle assembly, faithful chromosome segregation, and efficient mitotic progression (PubMed:40593606). May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm. {ECO:0000250|UniProtKB:A8I4E9, ECO:0000269|PubMed:40593606}.
uniprot
proteins
mass_dalton
71117
uniprot
proteins
protein_family
CFAP100 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
37192300
uniprot
proteins
pubmed
40593606
uniprot
proteins
sequence_length
611
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A8I4E9}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:40593606}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:37192300}. Note=Localizes to microtubules. {ECO:0000269|PubMed:37192300}.
uniprot
proteins