IGFBP6
entrez
3489
canonical
uniprot
P24592
canonical
ensembl
ENSG00000167779
resolver
ensp
ENSP00000301464
resolver
ensp
ENSP00000449344
resolver
enst
ENST00000301464
resolver
enst
ENST00000548176
resolver
genesymbol
IGFBP6
resolver
genesymbol_syn
IBP6
resolver
hgnc
HGNC:5475
resolver
uniprot
F8VVA5
resolver
uniprot
Q14492
resolver
uniprot_entry
F8VVA5_HUMAN
resolver
uniprot_entry
IBP6_HUMAN
resolver
uniprot_sec
Q14492
resolver
amino_acid_sequence
MTPHRLLPPLLLLLALLLAASPGGALARCPGCGQGVQAGCPGGCVEEEDGGSPAEGCAEAEGCLRREGQECGVYTPNCAPGLQCHPPKDDEAPLRALLLGRGRCLPARAPAVAEENPKESKPQAGTARPQDVNRRDQQRNPGTSTTPSQPNSAGVQDTEMGPCRRHLDSVLQQLQTEVYRGAQTLYVPNCDHRGFYRKRQCRSSQGQRRGPCWCVDRMGKSLPGSPDGNGSSSCPTGSSG
uniprot
proteins
function
FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration (PubMed:24003225). {ECO:0000269|PubMed:24003225}.
uniprot
proteins
mass_dalton
25322
uniprot
proteins
post_translational_modification
PTM: O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid. {ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:9572875}.
uniprot
proteins
pubmed
10087296
uniprot
proteins
pubmed
10329650
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1697583
uniprot
proteins
pubmed
1709161
uniprot
proteins
pubmed
1719383
uniprot
proteins
pubmed
1850257
uniprot
proteins
pubmed
19838169
uniprot
proteins
pubmed
2154495
uniprot
proteins
pubmed
24003225
uniprot
proteins
pubmed
2551732
uniprot
proteins
pubmed
9572875
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24003225}.
uniprot
proteins