Fmo2
entrez
55990
canonical
uniprot
Q8K2I3
canonical
ensembl
ENSMUSG00000040170
resolver
ensp
ENSMUSP00000044405
resolver
ensp
ENSMUSP00000107135
resolver
enst
ENSMUST00000045902
resolver
enst
ENSMUST00000111510
resolver
genesymbol
Fmo2
resolver
uniprot
Q9QZF7
resolver
uniprot_entry
FMO2_MOUSE
resolver
uniprot_sec
Q9QZF7
resolver
amino_acid_sequence
MAKKVVVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGLWRFKENVEDGRASIYRSVITNTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLKYIQFQTTVISVKKRPDFASSGQWEVYTQSNGKEQRTVFDAVMVCSGHHIQPHLPLKSFPGIERFRGQYFHSREYKHPVGFEGKRILVVGIGNSAADIASELSKTAAQVFVSTRHGSWVMSRISEDGYPWDMVFHTRFSSMLRNVLPRTVVKWMMEQQMNRWFNHENYGLVPQNKYLMKEPVLNDDLPSRLLYGAIKVKTRVKELTETAVVFEDGTVEEDVDIIVFATGYTFSFSFLEDSLVKVEDNRVSLYKAMFPPHLEKPTLACIGLIQPLGSIFPTVELQARWATRVFKGLCSLPSETTMMADIVERNEKRVNLFGKSQSQILQTNYVDYLDELALEIGAKPDFVSLFFKDPKLAVKLYFGPCNSYQYRLVGPGQWEGARNAILTQKQRILKPLKTRTLQSSDSAPVSFLLKILGLLAVVLAFFFQLQGF
uniprot
proteins
ec_number
1.14.13.-
uniprot
proteins
function
FUNCTION: Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation (PubMed:18930751). Catalyzes the S-oxygenation of the prodrug ethionamide (ETA) to the S-oxide (ETASO), the first step in its bioactivation following by the second oxygenation to the sulfinic acid but to a lesser extend (PubMed:18930751). {ECO:0000269|PubMed:18930751}.
uniprot
proteins
mass_dalton
60974
uniprot
proteins
protein_family
FMO family
uniprot
proteins
pubmed
11835629
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18930751
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
535
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:P17635}; Single-pass membrane protein {ECO:0000250|UniProtKB:P17635}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P17635}; Single-pass membrane protein {ECO:0000250|UniProtKB:P17635}.
uniprot
proteins
transmembrane_region
TRANSMEM 510..530; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins