FERMT2
entrez
10979
canonical
uniprot
Q96AC1
canonical
ensembl
ENSG00000073712
resolver
ensp
ENSP00000340391
resolver
ensp
ENSP00000342858
resolver
ensp
ENSP00000382243
resolver
ensp
ENSP00000545289
resolver
ensp
ENSP00000640439
resolver
ensp
ENSP00000640440
resolver
ensp
ENSP00000640441
resolver
genesymbol
FERMT2
resolver
genesymbol_syn
KIND2
resolver
genesymbol_syn
MIG2
resolver
genesymbol_syn
PLEKHC1
resolver
hgnc
HGNC:15767
resolver
uniprot
B5TJY2
resolver
uniprot
Q14840
resolver
uniprot
Q86TY7
resolver
uniprot_entry
FERM2_HUMAN
resolver
uniprot_sec
B5TJY2
resolver
uniprot_sec
Q14840
resolver
uniprot_sec
Q86TY7
resolver
amino_acid_sequence
MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYSSPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLTSGWV
uniprot
proteins
function
FUNCTION: Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}.
uniprot
proteins
mass_dalton
77861
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="H->A: Abolishes lipid-binding via the N-terminus; when associated with 74-A--A-81."; /evidence="ECO:0000269|PubMed:22078565"; MUTAGEN 74..81; /note="KTHWTLDK->ATAATLDA: Abolishes lipid-binding via the N-terminus; when associated with A-40."; /evidence="ECO:0000269|PubMed:22078565"; MUTAGEN 383; /note="K->A: Reduces phosphatidylinositol phosphate binding. Reduces integrin activation; when associated with A-385."; /evidence="ECO:0000269|PubMed:22030399"; MUTAGEN 385; /note="K->A: Reduces integrin activation; when associated with A-383."; /evidence="ECO:0000269|PubMed:22030399"; MUTAGEN 390; /note="K->A: Abolishes phosphatidylinositol phosphate binding."; /evidence="ECO:0000269|PubMed:21325030"; MUTAGEN 393; /note="K->A: Reduces phosphatidylinositol phosphate binding."; /evidence="ECO:0000269|PubMed:22030399"; MUTAGEN 614..615; /note="QW->AA: Impairs ITGB3 binding. Abolishes enhancement of talin-mediated integrin activation."; /evidence="ECO:0000269|PubMed:18458155
uniprot
proteins
protein_family
Kindlin family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12679033
uniprot
proteins
pubmed
12697302
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18458155
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21325030
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21768292
uniprot
proteins
pubmed
22030399
uniprot
proteins
pubmed
22078565
uniprot
proteins
pubmed
22653426
uniprot
proteins
pubmed
22699938
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8175911
uniprot
proteins
sequence_length
680
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cell surface {ECO:0000250}. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides.
uniprot
proteins