LRRC8D
entrez
55144
canonical
uniprot
Q7L1W4
canonical
ensembl
ENSG00000171492
resolver
ensp
ENSP00000338887
resolver
ensp
ENSP00000378093
resolver
ensp
ENSP00000576555
resolver
ensp
ENSP00000576556
resolver
ensp
ENSP00000576557
resolver
ensp
ENSP00000576558
resolver
ensp
ENSP00000576559
resolver
ensp
ENSP00000576560
resolver
ensp
ENSP00000576561
resolver
ensp
ENSP00000576562
resolver
ensp
ENSP00000576563
resolver
ensp
ENSP00000576564
resolver
ensp
ENSP00000576565
resolver
ensp
ENSP00000576566
resolver
ensp
ENSP00000576567
resolver
ensp
ENSP00000576568
resolver
ensp
ENSP00000576569
resolver
ensp
ENSP00000576570
resolver
ensp
ENSP00000576571
resolver
ensp
ENSP00000576574
resolver
ensp
ENSP00000576575
resolver
ensp
ENSP00000576576
resolver
ensp
ENSP00000576577
resolver
ensp
ENSP00000576578
resolver
ensp
ENSP00000576580
resolver
ensp
ENSP00000602634
resolver
ensp
ENSP00000602635
resolver
ensp
ENSP00000602636
resolver
ensp
ENSP00000617444
resolver
ensp
ENSP00000617445
resolver
ensp
ENSP00000617446
resolver
ensp
ENSP00000617447
resolver
enst
ENST00000337338
resolver
enst
ENST00000394593
resolver
enst
ENST00000906496
resolver
enst
ENST00000906497
resolver
enst
ENST00000906498
resolver
enst
ENST00000906499
resolver
enst
ENST00000906500
resolver
enst
ENST00000906501
resolver
enst
ENST00000906502
resolver
enst
ENST00000906503
resolver
enst
ENST00000906504
resolver
enst
ENST00000906505
resolver
enst
ENST00000906506
resolver
enst
ENST00000906507
resolver
enst
ENST00000906508
resolver
enst
ENST00000906509
resolver
enst
ENST00000906510
resolver
enst
ENST00000906512
resolver
enst
ENST00000906513
resolver
enst
ENST00000906514
resolver
enst
ENST00000906516
resolver
enst
ENST00000906518
resolver
enst
ENST00000906519
resolver
enst
ENST00000906520
resolver
enst
ENST00000906521
resolver
enst
ENST00000932575
resolver
enst
ENST00000932576
resolver
enst
ENST00000932577
resolver
enst
ENST00000947385
resolver
enst
ENST00000947386
resolver
enst
ENST00000947387
resolver
enst
ENST00000947388
resolver
genesymbol
LRRC8D
resolver
genesymbol_syn
LRRC5
resolver
hgnc
HGNC:16992
resolver
uniprot
B3KRU1
resolver
uniprot
D3DT29
resolver
uniprot
Q6UWB2
resolver
uniprot
Q96GG5
resolver
uniprot
Q9NVW3
resolver
uniprot_entry
B3KRU1_HUMAN
resolver
uniprot_entry
LRC8D_HUMAN
resolver
uniprot_entry
Q96GG5_HUMAN
resolver
uniprot_sec
D3DT29
resolver
uniprot_sec
Q6UWB2
resolver
uniprot_sec
Q9NVW3
resolver
amino_acid_sequence
MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDFALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVSTSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQDINIPFANGI
uniprot
proteins
function
FUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:32415200). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309). {ECO:0000250|UniProtKB:Q8BGR2, ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26530471, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731, ECO:0000269|PubMed:32415200, ECO:0000269|PubMed:33171122}.
uniprot
proteins
mass_dalton
98201
uniprot
proteins
mutagenesis
MUTAGEN 44; /note="T->C: Alters channel anion selectivity."; /evidence="ECO:0000269|PubMed:26824658"; MUTAGEN 143; /note="F->R: Affects ion selectivity of the channel. Reduced permeability to negatively charged glutamate and gluconate."; /evidence="ECO:0000269|PubMed:32415200
uniprot
proteins
protein_family
LRRC8 family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22532330
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24782309
uniprot
proteins
pubmed
24790029
uniprot
proteins
pubmed
26530471
uniprot
proteins
pubmed
26824658
uniprot
proteins
pubmed
28193731
uniprot
proteins
pubmed
32415200
uniprot
proteins
pubmed
33171122
uniprot
proteins
sequence_length
858
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:28193731}; Multi-pass membrane protein {ECO:0000269|PubMed:32415200}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24782309, ECO:0000305|PubMed:24790029}; Multi-pass membrane protein {ECO:0000269|PubMed:32415200}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed:24782309, PubMed:24790029). Requires LRRC8A for expression at the cell membrane (PubMed:24790029). {ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..48; /note="Helical; Name=1"; /evidence="ECO:0000305|PubMed:32415200, ECO:0007744|PDB:6M04"; TRANSMEM 164..182; /note="Helical; Name=2"; /evidence="ECO:0000305|PubMed:32415200, ECO:0007744|PDB:6M04"; TRANSMEM 309..328; /note="Helical; Name=3"; /evidence="ECO:0000305|PubMed:32415200, ECO:0007744|PDB:6M04"; TRANSMEM 361..386; /note="Helical; Name=4"; /evidence="ECO:0000305|PubMed:32415200, ECO:0007744|PDB:6M04
uniprot
proteins