TTLL1
entrez
25809
canonical
uniprot
O95922
canonical
ensembl
ENSG00000100271
resolver
ensp
ENSP00000266254
resolver
genesymbol
TTLL1
resolver
genesymbol_syn
C22orf7
resolver
hgnc
HGNC:1312
resolver
uniprot
B2RDS7
resolver
uniprot
Q9BR27
resolver
uniprot
Q9NRS9
resolver
uniprot
Q9UMU0
resolver
uniprot_entry
TTLL1_HUMAN
resolver
uniprot_sec
B2RDS7
resolver
uniprot_sec
Q9BR27
resolver
uniprot_sec
Q9NRS9
resolver
uniprot_sec
Q9UMU0
resolver
amino_acid_sequence
MAGKVKWVTDIEKSVLINNFEKRGWVQVTENEDWNFYWMSVQTIRNVFSVEAGYRLSDDQIVNHFPNHYELTRKDLMVKNIKRYRKELEKEGSPLAEKDENGKYLYLDFVPVTYMLPADYNLFVEEFRKSPSSTWIMKPCGKAQGKGIFLINKLSQIKKWSRDSKTSSFVSQSNKEAYVISLYINNPLLIGGRKFDLRLYVLVSTYRPLRCYMYKLGFCRFCTVKYTPSTSELDNMFVHLTNVAIQKHGEDYNHIHGGKWTVSNLRLYLESTRGKEVTSKLFDEIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDKLKPWLIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILYDEELAQGDGADRELRSRQGQSLGPRAGRSRDSGRAVLTTWK
uniprot
proteins
ec_number
6.3.2.-
uniprot
proteins
function
FUNCTION: Catalytic subunit of a polyglutamylase complex which modifies tubulin, generating side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:34782749). Probably involved in the side-chain elongation step of the polyglutamylation reaction rather than the initiation step. Modifies both alpha- and beta-tubulins with a preference for the alpha-tail. Unlike most polyglutamylases of the tubulin--tyrosine ligase family, only displays a catalytic activity when in complex with other proteins as it is most likely lacking domains important for autonomous activity. Part of the neuronal tubulin polyglutamylase complex. Mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility. Involved in respiratory motile cilia function through the regulation of beating asymmetry. Essential for sperm flagella biogenesis, motility and male fertility. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis. {ECO:0000250|UniProtKB:Q91V51, ECO:0000269|PubMed:34782749}.
uniprot
proteins
mass_dalton
48988
uniprot
proteins
mutagenesis
MUTAGEN 326; /note="E->G: Abolishes microtubule polyglutamylation. Decreases MAP4 recruitment to microtubules."; /evidence="ECO:0000269|PubMed:34782749
uniprot
proteins
protein_family
Tubulin polyglutamylase family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11054573
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12529303
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
34782749
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91V51}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q91V51}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q91V51}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q91V51}.
uniprot
proteins