Slc8b1
entrez
498185
canonical
uniprot
Q6AXS0
canonical
ensembl
ENSRNOG00000001383
resolver
ensembl
ENSRNOG00055015444
resolver
ensembl
ENSRNOG00060002352
resolver
ensembl
ENSRNOG00065007749
resolver
ensp
ENSRNOP00000034026
resolver
ensp
ENSRNOP00055021450
resolver
ensp
ENSRNOP00060002580
resolver
ensp
ENSRNOP00065008885
resolver
enst
ENSRNOT00000038736
resolver
enst
ENSRNOT00055026400
resolver
enst
ENSRNOT00060003720
resolver
enst
ENSRNOT00065012156
resolver
genesymbol
Slc8b1
resolver
genesymbol_syn
Nckx6
resolver
genesymbol_syn
Nclx
resolver
genesymbol_syn
Slc24a6
resolver
uniprot_entry
NCLX_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the sodium/calcium exchanger inhibitor CGP-37157. Strongly inhibited by zinc. {ECO:0000250|UniProtKB:Q6J4K2}.
uniprot
proteins
amino_acid_sequence
MAGRWLDPLWAPGFLCVALILETASGAGDLSTKAHGHIQFSARGVNQTAMADCRAVCSLNTSDRCDFVKRNPDCHSEGGYLDYLKGIFCYFPPNLLPLAITLYVFWLLYLFLILGVTAAKFFCPNLSAISTSLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPRTAGLAIGALFGAGVLVTTVVAGGITILRPFMAASRPFLRDITFYMVAVFLTFTALYLGRITLVWALGYLGLYVFYVVTVIICTWVYQRQRSRSLVHSISETPELLTDSEEDQMSSNTNSYDYGEEYRPLLLGEETTGQILLQALNPLDYRKWRTQSISCKLLKVAKLPVEFLLLLTVPVVDPDKDDRNWKRPLNCLQLVISPLVLVLTLQSGVYGIYEIGGLLPVWAVVVIVGTALASVTFFATSNSEPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQIVRSHASEVKLEPDGLLVWVLASALGLSLVFSLVSVPLQCFQLSKAYGLCLLLFYICFIVVVLLTEFGVIHLKAD
uniprot
proteins
function
FUNCTION: Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (By similarity). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (PubMed:40931067). Mitochondrial calcium export is ph-dependent (PubMed:40931067). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (By similarity). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (By similarity). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (By similarity). In contrast to other members of the family its function is independent of K(+) (By similarity). {ECO:0000250|UniProtKB:Q6J4K2, ECO:0000250|UniProtKB:Q925Q3, ECO:0000269|PubMed:40931067}.
uniprot
proteins
mass_dalton
63992
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-258 by PKA prevents calcium overload. {ECO:0000250|UniProtKB:Q6J4K2}.
uniprot
proteins
protein_family
Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family
uniprot
proteins
protein_family
SLC24A subfamily
uniprot
proteins
pubmed
14625281
uniprot
proteins
pubmed
15060069
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20018762
uniprot
proteins
pubmed
40931067
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:15060069, ECO:0000269|PubMed:20018762}; Multi-pass membrane protein {ECO:0000269|PubMed:15060069, ECO:0000269|PubMed:20018762}.
uniprot
proteins
transmembrane_region
TRANSMEM 96..132; /note="Helical; Name=1"; /evidence="ECO:0007744|PDB:9PS1, ECO:0007744|PDB:9PS2, ECO:0007744|PDB:9PS3, ECO:0007744|PDB:9PS4, ECO:0007744|PDB:9PS6, ECO:0007744|PDB:9PS8"; TRANSMEM 137..162; /note="Helical; Name=2"; /evidence="ECO:0007744|PDB:9PS1, ECO:0007744|PDB:9PS2, ECO:0007744|PDB:9PS3, ECO:0007744|PDB:9PS4, ECO:0007744|PDB:9PS6, ECO:0007744|PDB:9PS8"; TRANSMEM 166..192; /note="Helical; Name=3"; /evidence="ECO:0007744|PDB:9PS1, ECO:0007744|PDB:9PS2, ECO:0007744|PDB:9PS3, ECO:0007744|PDB:9PS4, ECO:0007744|PDB:9PS6, ECO:0007744|PDB:9PS8"; TRANSMEM 200..221; /note="Helical; Name=4"; /evidence="ECO:0007744|PDB:9PS1, ECO:0007744|PDB:9PS2, ECO:0007744|PDB:9PS3, ECO:0007744|PDB:9PS4, ECO:0007744|PDB:9PS6, ECO:0007744|PDB:9PS8"; TRANSMEM 227..255; /note="Helical; Name=5"; /evidence="ECO:0007744|PDB:9PS1, ECO:0007744|PDB:9PS2, ECO:0007744|PDB:9PS3, ECO:0007744|PDB:9PS4, ECO:0007744|PDB:9PS6, ECO:0007744|PDB:9PS8"; TRANSMEM 356..373; /note="Helical; Name=5"; /evidence="ECO:0007744|PDB:9PS1, ECO:0007744|PDB:9PS2, ECO:0007744|PDB:9PS3, ECO:0007744|PDB:9PS4, ECO:0007744|PDB:9PS6, ECO:0007744|PDB:9PS8"; TRANSMEM 389..409; /note="Helical; Name=7"; /evidence="ECO:0007744|PDB:9PS1, ECO:0007744|PDB:9PS2, ECO:0007744|PDB:9PS3, ECO:0007744|PDB:9PS4, ECO:0007744|PDB:9PS6, ECO:0007744|PDB:9PS8"; TRANSMEM 418..450; /note="Helical; Name=8"; /evidence="ECO:0007744|PDB:9PS1, ECO:0007744|PDB:9PS2, ECO:0007744|PDB:9PS3, ECO:0007744|PDB:9PS4, ECO:0007744|PDB:9PS6, ECO:0007744|PDB:9PS8"; TRANSMEM 455..480; /note="Helical; Name=9"; /evidence="ECO:0007744|PDB:9PS1, ECO:0007744|PDB:9PS2, ECO:0007744|PDB:9PS3, ECO:0007744|PDB:9PS4, ECO:0007744|PDB:9PS6, ECO:0007744|PDB:9PS8"; TRANSMEM 485..514; /note="Helical; Name=10"; /evidence="ECO:0007744|PDB:9PS1, ECO:0007744|PDB:9PS2, ECO:0007744|PDB:9PS3, ECO:0007744|PDB:9PS4, ECO:0007744|PDB:9PS6, ECO:0007744|PDB:9PS8"; TRANSMEM 527..549; /note="Helical; Name=11"; /evidence="ECO:0007744|PDB:9PS1, ECO:0007744|PDB:9PS2, ECO:0007744|PDB:9PS3, ECO:0007744|PDB:9PS4, ECO:0007744|PDB:9PS6, ECO:0007744|PDB:9PS8"; TRANSMEM 555..576; /note="Helical; Name=12"; /evidence="ECO:0007744|PDB:9PS1, ECO:0007744|PDB:9PS2, ECO:0007744|PDB:9PS3, ECO:0007744|PDB:9PS4, ECO:0007744|PDB:9PS6, ECO:0007744|PDB:9PS8
uniprot
proteins