CDCP1
entrez
64866
canonical
uniprot
Q9H5V8
canonical
ensembl
ENSG00000163814
resolver
ensp
ENSP00000296129
resolver
ensp
ENSP00000399342
resolver
ensp
ENSP00000573214
resolver
ensp
ENSP00000645494
resolver
genesymbol
CDCP1
resolver
genesymbol_syn
TRASK
resolver
hgnc
HGNC:24357
resolver
uniprot
Q49UB4
resolver
uniprot
Q6NT71
resolver
uniprot
Q6U9Y2
resolver
uniprot
Q8WU91
resolver
uniprot
Q96QU7
resolver
uniprot
Q9H676
resolver
uniprot
Q9H8C2
resolver
uniprot_entry
CDCP1_HUMAN
resolver
uniprot_sec
Q49UB4
resolver
uniprot_sec
Q6NT71
resolver
uniprot_sec
Q6U9Y2
resolver
uniprot_sec
Q8WU91
resolver
uniprot_sec
Q96QU7
resolver
uniprot_sec
Q9H676
resolver
uniprot_sec
Q9H8C2
resolver
amino_acid_sequence
MAGLNCGVSIALLGVLLLGAARLPRGAEAFEIALPRESNITVLIKLGTPTLLAKPCYIVISKRHITMLSIKSGERIVFTFSCQSPENHFVIEIQKNIDCMSGPCPFGEVQLQPSTSLLPTLNRTFIWDVKAHKSIGLELQFSIPRLRQIGPGESCPDGVTHSISGRIDATVVRIGTFCSNGTVSRIKMQEGVKMALHLPWFHPRNVSGFSIANRSSIKRLCIIESVFEGEGSATLMSANYPEGFPEDELMTWQFVVPAHLRASVSFLNFNLSNCERKEERVEYYIPGSTTNPEVFKLEDKQPGNMAGNFNLSLQGCDQDAQSPGILRLQFQVLVQHPQNESNKIYVVDLSNERAMSLTIEPRPVKQSRKFVPGCFVCLESRTCSSNLTLTSGSKHKISFLCDDLTRLWMNVEKTISCTDHRYCQRKSYSLQVPSDILHLPVELHDFSWKLLVPKDRLSLVLVPAQKLQQHTHEKPCNTSFSYLVASAIPSQDLYFGSFCPGGSIKQIQVKQNISVTLRTFAPSFQQEASRQGLTVSFIPYFKEEGVFTVTPDTKSKVYLRTPNWDRGLPSLTSVSWNISVPRDQVACLTFFKERSGVVCQTGRAFMIIQEQRTRAEEIFSLDEDVLPKPSFHHHSFWVNISNCSPTSGKQLDLLFSVTLTPRTVDLTVILIAAVGGGVLLLSALGLIICCVKKKKKKTNKGPAVGIYNDNINTEMPRQPKKFQKGRKDNDSHVYAVIEDTMVYGHLLQDSSGSFLQPEVDTYRPFQGTMGVCPPSPPTICSRAPTAKLATEEPPPRSPPESESEPYTFSHPNNGDVSSKDTDIPLLNTQEPMEPAE
uniprot
proteins
function
FUNCTION: May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. {ECO:0000269|PubMed:11466621, ECO:0000269|PubMed:12799299, ECO:0000269|PubMed:15153610, ECO:0000269|PubMed:16007225, ECO:0000269|PubMed:16404722, ECO:0000269|PubMed:8647901}.
uniprot
proteins
mass_dalton
92932
uniprot
proteins
mutagenesis
MUTAGEN 734; /note="Y->F: Impaired association with SRC."; /evidence="ECO:0000269|PubMed:15851033"; MUTAGEN 762; /note="Y->F: Impaired association with protein kinase PRKCG but not with SRC."; /evidence="ECO:0000269|PubMed:15851033
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5. {ECO:0000269|PubMed:12660814, ECO:0000269|PubMed:14739293, ECO:0000269|PubMed:16007225, ECO:0000269|PubMed:8647901}.; PTM: N-glycosylated. {ECO:0000269|PubMed:12660814, ECO:0000269|PubMed:14739293, ECO:0000269|PubMed:16007225}.; PTM: A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.
uniprot
proteins
pubmed
11466621
uniprot
proteins
pubmed
12660814
uniprot
proteins
pubmed
12799299
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14739293
uniprot
proteins
pubmed
15153610
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15851033
uniprot
proteins
pubmed
16007225
uniprot
proteins
pubmed
16404722
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17335815
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
8647901
uniprot
proteins
sequence_length
836
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Shedding may also lead to a soluble peptide.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 668..688; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins