DNAJA1
entrez
3301
canonical
uniprot
P31689
canonical
ensembl
ENSG00000086061
resolver
ensp
ENSP00000369127
resolver
genesymbol
DNAJA1
resolver
genesymbol_syn
DNAJ2
resolver
genesymbol_syn
HDJ2
resolver
genesymbol_syn
HSJ2
resolver
genesymbol_syn
HSPF4
resolver
hgnc
HGNC:5229
resolver
uniprot
B7Z5C0
resolver
uniprot
Q5T7Q0
resolver
uniprot
Q86TL9
resolver
uniprot_entry
B7Z5C0_HUMAN
resolver
uniprot_entry
DNJA1_HUMAN
resolver
uniprot_sec
Q5T7Q0
resolver
uniprot_sec
Q86TL9
resolver
amino_acid_sequence
MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLSDAKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS
uniprot
proteins
function
FUNCTION: Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as a co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}.
uniprot
proteins
mass_dalton
44868
uniprot
proteins
mutagenesis
MUTAGEN 394; /note="C->S: Loss of farnesylation."; /evidence="ECO:0000269|PubMed:14752510
uniprot
proteins
pubmed
10816573
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14752510
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15595953
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24318877
uniprot
proteins
pubmed
24512202
uniprot
proteins
pubmed
25281747
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
8334160
uniprot
proteins
pubmed
8334161
uniprot
proteins
pubmed
9192730
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:10816573}; Lipid-anchor {ECO:0000305|PubMed:10816573}. Cytoplasm {ECO:0000269|PubMed:10816573}. Microsome {ECO:0000250}. Nucleus {ECO:0000269|PubMed:10816573}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10816573}. Mitochondrion {ECO:0000250}. Note=Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei. {ECO:0000250}.
uniprot
proteins