Olr226
entrez
65140
canonical
uniprot
P23270
canonical
ensembl
ENSRNOG00000085613
resolver
ensp
ENSRNOP00000102048
resolver
enst
ENSRNOT00000139670
resolver
genesymbol
Olr226
resolver
uniprot_entry
OL226_RAT
resolver
amino_acid_sequence
MERRNHSGRVSEFVLLGFPAPAPLRVLLFFLSLLAYVLVLTENMLIIIAIRNHPTLHKPMYFFLANMSFLEIWYVTVTIPKMLAGFIGSKENHGQLISFEACMTQLYFFLGLGCTECVLLAVMAYDRYVAICHPLHYPVIVSSRLCVQMAAGSWAGGFGISMVKVFLISRLSYCGPNTINHFFCDVSPLLNLSCTDMSTAELTDFVLAIFILLGPLSVTGASYMAITGAVMRIPSAAGRHKAFSTCASHLTVVIIFYAASIFIYARPKALSAFDTNKLVSVLYAVIVPLFNPIIYCLRNQDVKRALRRTLHLAQDQEANTNKGSKNG
uniprot
proteins
function
FUNCTION: Odorant receptor for medium-chain aliphatic aldehydes, such as octanal, nonanal and trans-2-decenal (PubMed:10781022, PubMed:11100145, PubMed:19101476, PubMed:20608641, PubMed:9422698). Activated by aliphatic aldehydes with chains ranging from 5 to 11 carbon atoms, with preference for octanal (C8) (PubMed:10781022, PubMed:11100145, PubMed:19101476, PubMed:20608641, PubMed:9422698). Ligand-binding involves the formation of a reversible covalent Schiff base linkage with the aldehyde, causing a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL/G(olf) or GNAS/G(s)) (By similarity). In olfactory epithelium, couples to GNAL/G(olf), mediating activation of adenylate cyclase activity and increased production of cAMP, initiating a neuronal response that triggers the perception of a smell (By similarity). Beyond its role in olfaction, also acts as a regulator of inflammation (By similarity). In macrophages, activation by octanal, a product of lipid peroxidation during oxidative stress, triggers a signaling that promotes activation of the NLRP3 inflammasome, leading to the production of pro-inflammatory cytokines, such as IL1B, exacerbating inflammatory processes in vascular macrophages and contributing to atherosclerosis (By similarity). Outside of the olfactory system, in tissues lacking GNAL/G(olf), couples to GNAS/G(s), promoting activation of adenylate cyclase activity and production of cAMP (By similarity). {ECO:0000250|UniProtKB:O95222, ECO:0000250|UniProtKB:Q9QWU6, ECO:0000269|PubMed:10781022, ECO:0000269|PubMed:11100145, ECO:0000269|PubMed:19101476, ECO:0000269|PubMed:20608641, ECO:0000269|PubMed:9422698}.
uniprot
proteins
mass_dalton
36227
uniprot
proteins
mutagenesis
MUTAGEN 164; /note="K->A: Strongly decreased activation by octanal."; /evidence="ECO:0000269|PubMed:10781022"; MUTAGEN 204; /note="D->A: Increased activation by octanal."; /evidence="ECO:0000269|PubMed:10781022"; MUTAGEN 206; /note="V->I: Does not affect activation by octanal."; /evidence="ECO:0000269|PubMed:10781022
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10781022
uniprot
proteins
pubmed
11100145
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
1840504
uniprot
proteins
pubmed
19101476
uniprot
proteins
pubmed
20608641
uniprot
proteins
pubmed
9422698
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O95222}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..50; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 59..80; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 145..163; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 202..224; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 242..265; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 278..297; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins