Or6a2
entrez
18317
canonical
uniprot
Q9QWU6
canonical
ensembl
ENSMUSG00000070417
resolver
ensp
ENSMUSP00000091656
resolver
ensp
ENSMUSP00000146957
resolver
ensp
ENSMUSP00000147026
resolver
ensp
ENSMUSP00000147893
resolver
ensp
ENSMUSP00000149104
resolver
ensp
ENSMUSP00000150093
resolver
enst
ENSMUST00000094109
resolver
enst
ENSMUST00000207280
resolver
enst
ENSMUST00000208147
resolver
enst
ENSMUST00000211432
resolver
enst
ENSMUST00000214105
resolver
enst
ENSMUST00000216375
resolver
genesymbol
Or6a2
resolver
genesymbol_syn
Olfr2
resolver
uniprot
A0A1B0GSD4
resolver
uniprot
Q80WD6
resolver
uniprot_entry
Q80WD6_MOUSE
resolver
uniprot_entry
Q9QWU6_MOUSE
resolver
uniprot_sec
A0A1B0GSD4
resolver
amino_acid_sequence
MERRNHTGRVSEFVLLGFPAPAPLRALLFFLSLLAYVLVLTENILIITAIRNHPTLHKPMYFFLANMSFLEIWYVTVTIPKMLAGFIGSEENHGQLISFEACMTQLYFFLGLGCTECVLLAVMAYDRYVAICHPLHYPVIVSSRLCVQMAAGSWAGGFGISMVKVFLISRLSYCGPNTINHFFCDVSPLLNLSCTDMSTAELTDFILAIFILLGPLSVTGASYMAITGAVMRIPSAAGRHKAFSTCASHLTVVIIFYAASIFIYARPKALSAFDTNKLVSVLYAVIVPLLNPIIYCLRNQEVKKALRRTLHLAQGQDANTKKSSRDG
uniprot
proteins
function
FUNCTION: Odorant receptor for medium-chain aliphatic aldehydes, such as heptanal, octanal, nonanal and trans-2-decenal (PubMed:29569669, PubMed:35025664, PubMed:9875846). Activated by aliphatic aldehydes with chains ranging from 5 to 11 carbon atoms, with preference for heptanal (C7) and octanal (C8) (PubMed:29569669, PubMed:9875846). Ligand-binding involves the formation of a reversible covalent Schiff base linkage with the aldehyde, causing a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL/G(olf) or GNAS/G(s)) (By similarity). In olfactory epithelium, couples to GNAL/G(olf), mediating activation of adenylate cyclase activity and increased production of cAMP, initiating a neuronal response that triggers the perception of a smell (By similarity). Beyond its role in olfaction, also acts as a regulator of inflammation (PubMed:35025664, PubMed:41473953). In macrophages, activation by octanal, a product of lipid peroxidation during oxidative stress, triggers a signaling that promotes activation of the NLRP3 inflammasome, leading to the production of pro-inflammatory cytokines, such as IL1B, exacerbating inflammatory processes in vascular macrophages and contributing to atherosclerosis (PubMed:35025664, PubMed:41473953). Outside of the olfactory system, in tissues lacking GNAL/G(olf), couples to GNAS/G(s), promoting activation of adenylate cyclase activity and production of cAMP (PubMed:35025664). {ECO:0000250|UniProtKB:O95222, ECO:0000269|PubMed:29569669, ECO:0000269|PubMed:35025664, ECO:0000269|PubMed:41473953, ECO:0000269|PubMed:9875846}.
uniprot
proteins
mass_dalton
36151
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11416212
uniprot
proteins
pubmed
11875048
uniprot
proteins
pubmed
14611657
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
29569669
uniprot
proteins
pubmed
35025664
uniprot
proteins
pubmed
41473953
uniprot
proteins
pubmed
9875846
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O95222}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 56..76; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 145..165; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 243..263; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins