Pank1
entrez
75735
canonical
uniprot
Q8K4K6
canonical
ensembl
ENSMUSG00000033610
resolver
ensp
ENSMUSP00000043562
resolver
ensp
ENSMUSP00000108079
resolver
ensp
ENSMUSP00000320344
resolver
genesymbol
Pank1
resolver
genesymbol_syn
Pank
resolver
uniprot
Q543J7
resolver
uniprot
Q9D3K1
resolver
uniprot
Q9QXM8
resolver
uniprot_entry
PANK1_MOUSE
resolver
uniprot_entry
Q543J7_MOUSE
resolver
uniprot_sec
Q9D3K1
resolver
uniprot_sec
Q9QXM8
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform 1]: Strongly inhibited by non-esterified CoA (CoASH), acetyl-CoA and malonyl-CoA (PubMed:12095677). Also inhibited by palmitoyl CoA (PubMed:12095677). Inhibited by calcium hopantenate (PubMed:17379144). {ECO:0000269|PubMed:12095677, ECO:0000269|PubMed:17379144}.; ACTIVITY REGULATION: [Isoform 2]: Strongly inhibited by acetyl-CoA and modestly by malonyl-CoA (PubMed:10625688, PubMed:12095677, PubMed:16040613). Refractory to inhibition by both CoA and palmitoyl-CoA (PubMed:16040613). Inhibited by calcium hopantenate (PubMed:17379144). {ECO:0000269|PubMed:10625688, ECO:0000269|PubMed:12095677, ECO:0000269|PubMed:16040613, ECO:0000269|PubMed:17379144}.
uniprot
proteins
amino_acid_sequence
MRGRRAPRPGSTEVPAAARDADTLRARAASPVRGAQLAEDVGTPTGGGEERRGHQLPTAAPRLRESKPQGGSEDRGTADRDLQRGCQSRSPRTAPPVPGMGDRGAQHERAALQSPGAPEGAAAAVNGLLHNGFHPSAASSRDPPAPRFQLPSELQPQPLFAQHDSPAKKCRLRRRMDSGRKNRPPFPWFGMDIGGTLVKLVYFEPKDITAEEEQEEVENLKSIRKYLTSNTAYGKTGIRDVHLELKNLTMCGRKGNLHFIRFPTCAMHLFIQMGSEKNFSSLHTTLCATGGGAFKFEEDFRMIADLQLHKLDELDCLIQGLLYVDSVGFNGKPECYYFENPTNPELCQKKPYCLDNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALDMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNMMSKEKRESISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLLAYAMDFWSKGQLKALFLEHEGYFGAVGALLELFKMTDTQ
uniprot
proteins
ec_number
2.7.1.33
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis (PubMed:20559429, PubMed:22815849). Required for the hepatic CoA increase during the switch from glucose to fatty acid oxidation that occurs in the fasting state (PubMed:20559429). {ECO:0000269|PubMed:20559429, ECO:0000269|PubMed:22815849}.; FUNCTION: [Isoform 1]: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269|PubMed:12095677, ECO:0000269|PubMed:17379144}.; FUNCTION: [Isoform 2]: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269|PubMed:10625688, ECO:0000269|PubMed:12095677, ECO:0000269|PubMed:16040613, ECO:0000269|PubMed:17379144}.
uniprot
proteins
mass_dalton
60091
uniprot
proteins
mutagenesis
MUTAGEN 4..5; /note="RR->AA: Loss of nuclear localization."; /evidence="ECO:0000269|PubMed:23152917"; MUTAGEN 168..183; /note="KKCRLRRRMDSGRKNR->AACALAAAMDSGAANA: Loss of nuclear localization."; /evidence="ECO:0000269|PubMed:23152917
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. {ECO:0000269|PubMed:10625688, ECO:0000269|PubMed:12095677, ECO:0000269|PubMed:17379144, ECO:0000269|PubMed:20559429, ECO:0000269|PubMed:22815849}.
uniprot
proteins
protein_family
Type II pantothenate kinase family
uniprot
proteins
pubmed
10625688
uniprot
proteins
pubmed
12095677
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16040613
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17379144
uniprot
proteins
pubmed
20559429
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22815849
uniprot
proteins
pubmed
23152917
uniprot
proteins
sequence_length
548
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:23152917}. Nucleus, nucleolus {ECO:0000269|PubMed:23152917}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16040613, ECO:0000269|PubMed:23152917}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:23152917}. Recycling endosome {ECO:0000269|PubMed:23152917}.
uniprot
proteins