CD40
entrez
958
canonical
uniprot
P25942
canonical
ensembl
ENSG00000101017
resolver
ensp
ENSP00000361350
resolver
ensp
ENSP00000361359
resolver
ensp
ENSP00000512093
resolver
ensp
ENSP00000560921
resolver
ensp
ENSP00000560922
resolver
ensp
ENSP00000606356
resolver
ensp
ENSP00000672031
resolver
ensp
ENSP00000672033
resolver
ensp
ENSP00000672034
resolver
enst
ENST00000695671
resolver
genesymbol
CD40
resolver
genesymbol_syn
TNFRSF5
resolver
hgnc
HGNC:11919
resolver
uniprot
A0A0S2Z349
resolver
uniprot
A0A0S2Z3C7
resolver
uniprot
A0A8Q3SI60
resolver
uniprot
E1P5S9
resolver
uniprot
Q53GN5
resolver
uniprot
Q5JY15
resolver
uniprot
Q5U007
resolver
uniprot
Q6P2H9
resolver
uniprot
Q7M4Q8
resolver
uniprot
Q86YK5
resolver
uniprot
Q9BYU0
resolver
uniprot_entry
A0A0S2Z349_HUMAN
resolver
uniprot_entry
A0A0S2Z3C7_HUMAN
resolver
uniprot_entry
A0A8Q3SI60_HUMAN
resolver
uniprot_entry
Q6P2H9_HUMAN
resolver
uniprot_entry
TNR5_HUMAN
resolver
uniprot_sec
E1P5S9
resolver
uniprot_sec
Q53GN5
resolver
uniprot_sec
Q5JY15
resolver
uniprot_sec
Q5U007
resolver
uniprot_sec
Q7M4Q8
resolver
uniprot_sec
Q86YK5
resolver
uniprot_sec
Q9BYU0
resolver
amino_acid_sequence
MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCETKDLVVQQAGTNKTDVVCGPQDRLRALVVIPIIFGILFAILLVLVFIKKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency with hyper-IgM 3 (HIGM3) [MIM:606843]: A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections. {ECO:0000269|PubMed:11675497, ECO:0000269|PubMed:26545377}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). {ECO:0000250|UniProtKB:P27512, ECO:0000269|PubMed:31331973}.
uniprot
proteins
mass_dalton
30619
uniprot
proteins
pubmed
10984535
uniprot
proteins
pubmed
11172023
uniprot
proteins
pubmed
11675497
uniprot
proteins
pubmed
11676606
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12005438
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2463309
uniprot
proteins
pubmed
2475341
uniprot
proteins
pubmed
26545377
uniprot
proteins
pubmed
31331973
uniprot
proteins
pubmed
7530216
uniprot
proteins
pubmed
7533327
uniprot
proteins
pubmed
9037712
uniprot
proteins
pubmed
9432981
uniprot
proteins
pubmed
9511754
uniprot
proteins
pubmed
9605317
uniprot
proteins
pubmed
9718306
uniprot
proteins
sequence_length
277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform I]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform II]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 194..215; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins