Syt4
entrez
20983
canonical
uniprot
P40749
canonical
ensembl
ENSMUSG00000024261
resolver
ensp
ENSMUSP00000025110
resolver
enst
ENSMUST00000025110
resolver
genesymbol
Syt4
resolver
genesymbol_syn
Syt3
resolver
uniprot
Q3UFC1
resolver
uniprot
Q8BGH3
resolver
uniprot
Q8BRL6
resolver
uniprot_entry
SYT4_MOUSE
resolver
uniprot_sec
Q3UFC1
resolver
uniprot_sec
Q8BGH3
resolver
uniprot_sec
Q8BRL6
resolver
amino_acid_sequence
MAPITTSRVEFDEIPTVVGIFSAFGLVFTVSLFAWICCQRRSAKSNKTPPYKFVHVLKGVDIYPENLSSKKKFGGDDKSEVKGKAALPNLSLHLDLEKRDLNGNFPKANPKAGSSSDLENVTPKLFTETEKEANSPESLKSSTSLTSEEKQEKLGTLFLSLEYNFEKKAFVVNIKEAQGLPAMDEQSMTSDPYIKMTILPEKKHRVKTRVLRKTLDPVFDETFTFYGIPYPHIQELSLHFTVLSFDRFSRDDVIGEVLIPLSGIELSDGKMLMTREIIKRNAKKSSGRGELLVSLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVFDIPCESLEEISVEFLVLDSERGSRNEVIGRLVLGATAEGSGGGHWKEICDFPRRQIAKWHMLCDG
uniprot
proteins
function
FUNCTION: Synaptotagmin family member which does not bind Ca(2+). Plays a role in dendrite formation by melanocytes (By similarity). {ECO:0000250|UniProtKB:P50232, ECO:0000250|UniProtKB:Q9H2B2}.; FUNCTION: Synaptotagmin family member which does not bind Ca(2+) (By similarity). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (PubMed:29166604). Plays a role in dendrite formation by melanocytes (By similarity). {ECO:0000250|UniProtKB:P50232, ECO:0000250|UniProtKB:Q9H2B2, ECO:0000269|PubMed:29166604}.
uniprot
proteins
mass_dalton
47659
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-135 by MAPK8/JNK1 reduces interaction with KIF1A and neuronal dense core vesicles mobility. {ECO:0000250|UniProtKB:P50232}.
uniprot
proteins
protein_family
Synaptotagmin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29166604
uniprot
proteins
pubmed
8058779
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000250|UniProtKB:P50232}; Single-pass membrane protein {ECO:0000250|UniProtKB:P50232}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins