RAB22A
entrez
57403
canonical
uniprot
Q9UL26
canonical
ensembl
ENSG00000124209
resolver
ensp
ENSP00000244040
resolver
enst
ENST00000244040
resolver
genesymbol
RAB22A
resolver
genesymbol_syn
RAB22
resolver
hgnc
HGNC:9764
resolver
uniprot
B3KR86
resolver
uniprot
E1P605
resolver
uniprot
Q8TF12
resolver
uniprot
Q9H4E6
resolver
uniprot_entry
RB22A_HUMAN
resolver
uniprot_sec
B3KR86
resolver
uniprot_sec
E1P605
resolver
uniprot_sec
Q8TF12
resolver
uniprot_sec
Q9H4E6
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including RINL, which promote the exchange of bound GDP for free GTP (PubMed:21419809). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000269|PubMed:21419809, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MALRELKVCLLGDTGVGKSSIVWRFVEDSFDPNINPTIGASFMTKTVQYQNELHKFLIWDTAGQERFRALAPMYYRGSAAAIIVYDITKEETFSTLKNWVKELRQHGPPNIVVAIAGNKCDLIDVREVMERDAKDYADSIHAIFVETSAKNAININELFIEISRRIPSTDANLPSGGKGFKLRRQPSEPKRSCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:16537905, PubMed:21849477). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:16537905). RAB22A plays a role in endocytosis and intracellular protein transport. Mediates trafficking of transferrin/TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Has low GTPase activity (PubMed:16537905). {ECO:0000269|PubMed:16537905, ECO:0000269|PubMed:21849477}.
uniprot
proteins
mass_dalton
21855
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="S->L: Loss of GTPase activity."; /evidence="ECO:0000269|PubMed:21419809"; MUTAGEN 64; /note="Q->L: Constitutive GTPase activity. Impairs normal protein trafficking through early endosomes."; /evidence="ECO:0000269|PubMed:16537905, ECO:0000269|PubMed:21419809
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10887961
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16537905
uniprot
proteins
pubmed
21255211
uniprot
proteins
pubmed
21419809
uniprot
proteins
pubmed
21849477
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
32475639
uniprot
proteins
sequence_length
194
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:P51154}; Lipid-anchor {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P51154}; Lipid-anchor {ECO:0000305}. Early endosome {ECO:0000269|PubMed:16537905}. Late endosome {ECO:0000250|UniProtKB:P51154}. Cell projection, ruffle {ECO:0000269|PubMed:21419809}. Cytoplasmic vesicle {ECO:0000269|PubMed:21419809}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000269|PubMed:21255211}.
uniprot
proteins