OPN5
entrez
221391
canonical
uniprot
Q6U736
canonical
ensembl
ENSG00000124818
resolver
ensp
ENSP00000360255
resolver
enst
ENST00000371211
resolver
genesymbol
OPN5
resolver
genesymbol_syn
GPR136
resolver
genesymbol_syn
PGR12
resolver
genesymbol_syn
TMEM13
resolver
hgnc
HGNC:19992
resolver
uniprot
A0AV33
resolver
uniprot
Q5T5B9
resolver
uniprot
Q5T886
resolver
uniprot
Q7Z603
resolver
uniprot
Q86SL5
resolver
uniprot_entry
OPN5_HUMAN
resolver
uniprot_sec
A0AV33
resolver
uniprot_sec
Q5T5B9
resolver
uniprot_sec
Q5T886
resolver
uniprot_sec
Q7Z603
resolver
uniprot_sec
Q86SL5
resolver
amino_acid_sequence
MALNHTALPQDERLPHYLRDGDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGISVVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSYGVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYVPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEGFRLHTVTTVRKSSAVLEIHEEWE
uniprot
proteins
function
FUNCTION: G protein-coupled photoreceptor that selectively activates G(i) protein in response to light in the retina (By similarity). Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (PubMed:22043319). Acts as a bistable protein with absorption peaks at 380 nm (UVA light) and 470 nm (blue light), allowing photoreversible regeneration of the cis-retinal chromophore after stimulation (PubMed:22043319). Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake. Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock. Acts as a circadian photoreceptor in the outer ear and vibrissal pads, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle. Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling. Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels. Mediates violet light-accelerated wound healing in corneas, being transiently expressed following physical injury (By similarity). {ECO:0000250|UniProtKB:Q6VZZ7, ECO:0000269|PubMed:22043319}.
uniprot
proteins
mass_dalton
39727
uniprot
proteins
post_translational_modification
PTM: It is uncertain whether Cys-315 or Cys-316 is palmitoylated. {ECO:0000305}.; PTM: Contains one retinal chromophore covalently bound to a lysine residue via a Schiff base. Upon light absorption, the bound 11-cis-retinal isomerizes to all-trans-retinal. Following light exposure, all-trans-retinal is photoreconverted to 11-cis-retinal. {ECO:0000269|PubMed:22043319}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Opsin subfamily
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14623098
uniprot
proteins
pubmed
14623103
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22043319
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6VZZ7}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 75..95; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 109..129; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 151..171; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 198..218; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 253..273; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins