CYFIP1
entrez
23191
canonical
uniprot
Q7L576
canonical
ensembl
ENSG00000273749
resolver
ensembl
ENSG00000288461
resolver
ensp
ENSP00000478779
resolver
ensp
ENSP00000480525
resolver
ensp
ENSP00000481038
resolver
ensp
ENSP00000570918
resolver
ensp
ENSP00000570928
resolver
ensp
ENSP00000590032
resolver
genesymbol
CYFIP1
resolver
genesymbol_syn
KIAA0068
resolver
hgnc
HGNC:13759
resolver
uniprot
A8K6D9
resolver
uniprot
Q14467
resolver
uniprot
Q5IED0
resolver
uniprot
Q6ZSX1
resolver
uniprot
Q9BSD9
resolver
uniprot
Q9BVC7
resolver
uniprot_entry
CYFP1_HUMAN
resolver
uniprot_sec
A8K6D9
resolver
uniprot_sec
Q14467
resolver
uniprot_sec
Q5IED0
resolver
uniprot_sec
Q6ZSX1
resolver
uniprot_sec
Q9BSD9
resolver
uniprot_sec
Q9BVC7
resolver
amino_acid_sequence
MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS
uniprot
proteins
function
FUNCTION: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers. {ECO:0000250|UniProtKB:Q7TMB8, ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:19524508, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:9417078}.
uniprot
proteins
mass_dalton
145182
uniprot
proteins
mutagenesis
MUTAGEN 179; /note="C->R: Reduced interaction with RAC1."; /evidence="ECO:0000269|PubMed:21107423"; MUTAGEN 190; /note="R->D: Reduced interaction with RAC1."; /evidence="ECO:0000269|PubMed:21107423"; MUTAGEN 434; /note="E->K: Reduced interaction with RAC1; when associated with A-626."; /evidence="ECO:0000269|PubMed:21107423"; MUTAGEN 626; /note="F->A: Reduced interaction with RAC1; when associated with K-434."; /evidence="ECO:0000269|PubMed:21107423"; MUTAGEN 632; /note="M->D: Reduced interaction with RAC1."; /evidence="ECO:0000269|PubMed:21107423"; MUTAGEN 697; /note="L->D: Constitutive induction of the formation of actin filaments; when associated with D-704."; /evidence="ECO:0000269|PubMed:21107423"; MUTAGEN 704; /note="Y->D: Constitutive induction of the formation of actin filaments; when associated with D-697."; /evidence="ECO:0000269|PubMed:21107423"; MUTAGEN 841; /note="L->A: Constitutive induction of the formation of actin filaments; when associated with 844-A-A-845."; /evidence="ECO:0000269|PubMed:21107423"; MUTAGEN 844..845; /note="FW->AA: Constitutive induction of the formation of actin filaments; when associated with A-841."; /evidence="ECO:0000269|PubMed:21107423
uniprot
proteins
protein_family
CYFIP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16260607
uniprot
proteins
pubmed
16417406
uniprot
proteins
pubmed
19524508
uniprot
proteins
pubmed
21107423
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7584044
uniprot
proteins
pubmed
9417078
uniprot
proteins
sequence_length
1253
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7TMB8}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TMB8}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q7TMB8}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q7TMB8}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q7TMB8}. Note=Highly expressed in the perinuclear region (By similarity). Enriched in synaptosomes (By similarity). Also enriched in membrane ruffles and at the tips of lamellipodia (By similarity). {ECO:0000250|UniProtKB:Q7TMB8}.
uniprot
proteins