Rcc1l
entrez
94254
canonical
uniprot
Q9CYF5
canonical
ensembl
ENSMUSG00000061979
resolver
ensp
ENSMUSP00000075581
resolver
ensp
ENSMUSP00000193837
resolver
ensp
ENSMUSP00000193846
resolver
enst
ENSMUST00000076228
resolver
genesymbol
Rcc1l
resolver
genesymbol_syn
Wbscr16
resolver
uniprot
Q548B0
resolver
uniprot_entry
Q548B0_MOUSE
resolver
uniprot_entry
RCC1L_MOUSE
resolver
amino_acid_sequence
MLAAARALRGPRPRWPTPAREHWTPAGRSRSRREAAEAEADVPVFQYVGERAARADRVFVWGFSFSGALGVPSFVVPSSGPGPRAGLRPRRRIQPVPYRLELDHKISSAACGYGFTLLSSKTKDVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVPLPLDRPQETKVLQVSCGRAHSLVLTDREGVFSMGNNSHGQCGRKVVEDEVYSESHKVHRMQDFDGQVVQVVCGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSTPSKLGGDLAGVTVVQVATYGDCCLALSADGGVFGWGNSEYLQLASVTDSTQVNVPRCLPFSGVGKVKQVACGGTGCAVLNAEGHVFVWGYGILGKGPKLLETAIPEMIPPTLFGLTEFNPEVQVSQIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAKSFI
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion (PubMed:28746876). Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system (By similarity). {ECO:0000250|UniProtKB:Q96I51, ECO:0000269|PubMed:28746876}.
uniprot
proteins
mass_dalton
49995
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
28746876
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:28746876}.
uniprot
proteins