Slc35a3
entrez
310808
canonical
uniprot
Q6AXR5
canonical
ensembl
ENSRNOG00055001101
resolver
ensembl
ENSRNOG00060000992
resolver
ensembl
ENSRNOG00065022405
resolver
ensp
ENSRNOP00055001418
resolver
ensp
ENSRNOP00060000589
resolver
ensp
ENSRNOP00065030954
resolver
enst
ENSRNOT00055001818
resolver
enst
ENSRNOT00060001324
resolver
enst
ENSRNOT00065038236
resolver
genesymbol
Slc35a3
resolver
uniprot_entry
S35A3_RAT
resolver
amino_acid_sequence
MSANLKYLSLGILVFQTTSLVLTMRYSRTLKEEGPRYLSSTAVVVAEFLKIMACIFLVYKDSKCSVRTLNRVLHDEILNKPMETLKLAIPSGIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVSMLGKKLGMYQWLSLVILMAGVAFVQWPSDSQELNSKDLSTGSQFVGLMAVLIACFSSGFAGVYFEKILKETKQSVWIRNIQLGFFGSIFGLMGVYVYDGELVSKNGFFQGYNQLTWIVVVLQALGGLVIAAVIKYADNILKGFATSLSIILSTIISYFWLQDFVPTSVFFLGAILVIAATFLYGYDPKPAGNPTKA
uniprot
proteins
function
FUNCTION: Transports diphosphate-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into the lumen of the Golgi apparatus, functioning as an antiporter that exchanges UDP-N-acetyl-alpha-D-glucosamine for UMP. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate highly branched, multiantennary complex N-glycans and keratan sulfate. However, the exact role of SLC35A3 still needs to be elucidated, it could be a member of a catalytically more efficient multiprotein complex rather than function independently as a single transporter. {ECO:0000250|UniProtKB:Q9Y2D2}.
uniprot
proteins
mass_dalton
36079
uniprot
proteins
post_translational_modification
PTM: O-Glcnacylation regulates the stability of SLC35A3 and the specific complex formation with MGAT4B. {ECO:0000250|UniProtKB:Q9Y2D2}.
uniprot
proteins
protein_family
Nucleotide-sugar transporter family
uniprot
proteins
protein_family
SLC35A subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Y2D2}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 174..194; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 212..232; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 243..263; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins