IGFBP3
entrez
3486
canonical
uniprot
P17936
canonical
ensembl
ENSG00000146674
resolver
ensp
ENSP00000370473
resolver
ensp
ENSP00000477772
resolver
genesymbol
IGFBP3
resolver
genesymbol_syn
IBP3
resolver
hgnc
HGNC:5472
resolver
uniprot
A4D2F5
resolver
uniprot
B3KPF0
resolver
uniprot
D3DVM0
resolver
uniprot
Q2V509
resolver
uniprot
Q6P1M6
resolver
uniprot
Q9UCL4
resolver
uniprot_entry
B3KPF0_HUMAN
resolver
uniprot_entry
IBP3_HUMAN
resolver
uniprot_sec
A4D2F5
resolver
uniprot_sec
D3DVM0
resolver
uniprot_sec
Q2V509
resolver
uniprot_sec
Q6P1M6
resolver
uniprot_sec
Q9UCL4
resolver
amino_acid_sequence
MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
uniprot
proteins
function
FUNCTION: Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:10874028, PubMed:19556345). Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (PubMed:20353938). Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1 (PubMed:9252371). Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade (PubMed:15371331). In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis (PubMed:10874028). {ECO:0000269|PubMed:10874028, ECO:0000269|PubMed:15371331, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19556345, ECO:0000269|PubMed:19623253, ECO:0000269|PubMed:19952275, ECO:0000269|PubMed:20353938}.
uniprot
proteins
mass_dalton
31674
uniprot
proteins
mutagenesis
MUTAGEN 194; /note="S->A: Strongly enhanced apoptotic potential."; /evidence="ECO:0000269|PubMed:19556345"; MUTAGEN 202; /note="S->A: No change in apoptotic potential."; /evidence="ECO:0000269|PubMed:19556345"; MUTAGEN 215; /note="R->E: Completely abolished ALS binding."; /evidence="ECO:0000269|PubMed:35907924
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FAM20C in the extracellular medium. Phosphorylated by CK2; resulting in decreased nuclear localization (PubMed:19556345). {ECO:0000269|PubMed:19556345, ECO:0000269|PubMed:26091039}.
uniprot
proteins
pubmed
10874028
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14561895
uniprot
proteins
pubmed
14760718
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15371331
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
1695633
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
1697583
uniprot
proteins
pubmed
1726837
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19556345
uniprot
proteins
pubmed
19623253
uniprot
proteins
pubmed
19952275
uniprot
proteins
pubmed
20353938
uniprot
proteins
pubmed
2464130
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
26216267
uniprot
proteins
pubmed
35907924
uniprot
proteins
pubmed
7508771
uniprot
proteins
pubmed
9252371
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20353938}. Nucleus {ECO:0000269|PubMed:10874028, ECO:0000269|PubMed:19556345}.
uniprot
proteins