Smarca5
entrez
93762
canonical
uniprot
Q91ZW3
canonical
ensembl
ENSMUSG00000031715
resolver
ensp
ENSMUSP00000044361
resolver
enst
ENSMUST00000043359
resolver
genesymbol
Smarca5
resolver
genesymbol_syn
Snf2h
resolver
uniprot
Q8C791
resolver
uniprot
Q8CA22
resolver
uniprot
Q8VDG1
resolver
uniprot
Q925M9
resolver
uniprot_entry
SMCA5_MOUSE
resolver
uniprot_sec
Q8C791
resolver
uniprot_sec
Q8CA22
resolver
uniprot_sec
Q8VDG1
resolver
uniprot_sec
Q925M9
resolver
amino_acid_sequence
MSSAVEPPPPPPPESAPSKPSAAGAGGSSSGNKGGPEGGAAPAAPCAAGSGPADTEMEEVFDHGSPGKQKEIQEPDPTYEEKMQTDRANRFEYLLKQTELFAHFIQPAAQKTPTSPLKMKPGRPRVKKDEKQNLLSVGDYRHRRTEQEEDEELLTESSKATNVCTRFEDSPSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKKWVPTLRSVCLIGDKEQRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVFNSADDFDSWFDTNNCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDILNSAGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVDQNLNKIGKDEMLQMIRHGATHVFASKESEITDEDIDGILERGAKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYREKQKIAFTEWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKVPRSPDLPNAAQAQKEEQLKIDEAEPLNDEELEEKEKLLTQGFTNWNKRDFNQFIKANEKWGRDDIENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDTKIGRYKAPFHQLRISYGTNKGKNYTEEEDRFLICMLHKLGFDKENVYDELRQCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENMELEEKEKAEKKKRGPKPSTQKRKMDGAPDGRGRKKKLKL
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (By similarity). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:11532953, PubMed:11980720, PubMed:12198165). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:11532953, PubMed:11980720, PubMed:12198165). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (By similarity). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:11532953, PubMed:11980720, PubMed:12198165). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (By similarity). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (By similarity). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (By similarity). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (PubMed:12198165). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (PubMed:19092802). Essential component of the NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (PubMed:11532953, PubMed:12198165, PubMed:12368916). Required for embryonic development and differentiation, and the proliferation of early blastocyst-derived stem cells (PubMed:14617767). {ECO:0000250|UniProtKB:O60264, ECO:0000269|PubMed:11532953, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198165, ECO:0000269|PubMed:12368916, ECO:0000269|PubMed:14617767, ECO:0000269|PubMed:19092802}.
uniprot
proteins
mass_dalton
121627
uniprot
proteins
protein_family
ISWI subfamily
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
10914549
uniprot
proteins
pubmed
11359880
uniprot
proteins
pubmed
11532953
uniprot
proteins
pubmed
11980720
uniprot
proteins
pubmed
12198165
uniprot
proteins
pubmed
12368916
uniprot
proteins
pubmed
14617767
uniprot
proteins
pubmed
15284901
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16514417
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19092802
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
34197713
uniprot
proteins
sequence_length
1051
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:11532953}. Chromosome {ECO:0000250|UniProtKB:O60264}. Note=Localizes to mitotic chromosomes. Co-localizes with RSF1 in the nucleus. Co-localizes with PCNA at replication foci during S phase. Co-localizes with BAZ1B/WSTF at replication foci during late-S phase. Recruited to DNA damage sites following interaction with SIRT6. {ECO:0000250|UniProtKB:O60264}.
uniprot
proteins