Eif3j
entrez
691947
canonical
uniprot
A0JPM9
canonical
ensembl
ENSRNOG00000016459
resolver
ensembl
ENSRNOG00055002860
resolver
ensembl
ENSRNOG00060015976
resolver
ensembl
ENSRNOG00065027435
resolver
ensp
ENSRNOP00000085035
resolver
ensp
ENSRNOP00055003313
resolver
ensp
ENSRNOP00060021985
resolver
ensp
ENSRNOP00065038802
resolver
enst
ENSRNOT00000097521
resolver
enst
ENSRNOT00055004473
resolver
enst
ENSRNOT00060027393
resolver
enst
ENSRNOT00065047316
resolver
genesymbol
Eif3j
resolver
genesymbol_syn
Eif3s1
resolver
uniprot_entry
EIF3J_RAT
resolver
amino_acid_sequence
MAAAAAAAAGDSDSWDADTFSMEDPVRKVAGGGTAGGDRWEGEDEDEDVKDNWDDDDDENKEEAEVKPEVKISEKKKIAEKIKEKERQQKKRQEEIKKRLEEPEESKVLTPEEQLADKLRLKKLQEESDLELAKETFGVNNTVYGIDAMNPSSRDDFTEFGKLLKDKITQYEKSLYYASFLEALVRDVCISLEIDDLKKITNSLTVLCSEKQKQEKQSKAKKKKKGVVPGGGLKATMKDDLADYGGYDGGYVQDYEDFM
uniprot
proteins
function
FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA. {ECO:0000255|HAMAP-Rule:MF_03009}.
uniprot
proteins
mass_dalton
29187
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation is enhanced upon serum stimulation. {ECO:0000255|HAMAP-Rule:MF_03009}.
uniprot
proteins
protein_family
EIF-3 subunit J family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03009}.
uniprot
proteins