Hcn4
entrez
59266
canonical
uniprot
Q9JKA7
canonical
ensembl
ENSRNOG00000009450
resolver
ensembl
ENSRNOG00055026865
resolver
ensembl
ENSRNOG00060021774
resolver
ensembl
ENSRNOG00065006640
resolver
ensp
ENSRNOP00000012644
resolver
ensp
ENSRNOP00055038068
resolver
ensp
ENSRNOP00060031103
resolver
ensp
ENSRNOP00065007498
resolver
enst
ENSRNOT00000012644
resolver
enst
ENSRNOT00055046403
resolver
enst
ENSRNOT00060037711
resolver
enst
ENSRNOT00065010265
resolver
genesymbol
Hcn4
resolver
uniprot
Q9QZW4
resolver
uniprot_entry
HCN4_RAT
resolver
uniprot_sec
Q9QZW4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cAMP and at 100 times higher concentrationsand to a lesser extent by cGMP and cCMP. cAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening. Binding of cAMP removes a tonic inhibition conferred by cyclic nucleotide-binding domain (CNBD) on channel opening. Cyclic dinucleotides can modulate HCN4 channel; cyclic dinucleotides acting as potent antagonists of cAMP. Inhibited by extracellular Cs(+) ions (By similarity). Auxiliary subunits can also regulate HCN4 channel. IRAG1 causes a gain-of-function by shifting HCN4 activation to more depolarized membrane potentials in the absence of cAMP. In contrast, IRAG2 causes a loss-of-function by inhibiting cAMP-dependent potentiation of HCN4 activation (By similarity). {ECO:0000250|UniProtKB:O70507, ECO:0000250|UniProtKB:Q9Y3Q4}.
uniprot
proteins
amino_acid_sequence
MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDGEEEGAGGLQDPSRRSIRLRPLPSPSPSVAAGCSESRGAALGAADSEGPGRSAGKSSTNGDCRRFRGSLASLGSRGGGSGGAGGGSSLGHLHDSAEERRLIAAEGDASPGEDRTPPGLATEPERPGAAAQPAASPPPQQPPQPASASCEQPSADTAIKVEGGAAASDQILPEAEVRLGQSGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFVVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCWVSINGMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVRHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGPGLGNLGAGQTPRHPRRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPPGLSPLLPSSSSSPPPGACSSPPAPTPSTSTAATTTGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPPPPLPGARGGLGLLEHFLPPPPSSRSPSSSPGQLGQPPGELSPGLAAGPPSTPETPPRPERPSFMAGASGGASPVAFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFSLYPRAGGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARAASSGGPPLTAAPQREPGARSEPVRSKLPSNL
uniprot
proteins
function
FUNCTION: Hyperpolarization-activated ion channel that are permeable to Na(+) and K(+) ions with very slow activation and inactivation. Exhibits higher selectivity for K(+) over Na(+) ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. Contributes to the native pacemaker currents in neurons (Ih) (By similarity). May mediate responses to sour stimuli (PubMed:11675786). {ECO:0000250|UniProtKB:Q9Y3Q4, ECO:0000269|PubMed:11675786}.
uniprot
proteins
mass_dalton
128761
uniprot
proteins
post_translational_modification
PTM: S-palmitoylated. {ECO:0000250|UniProtKB:Q9Y3Q4}.
uniprot
proteins
protein_family
Potassium channel HCN family
uniprot
proteins
pubmed
10400919
uniprot
proteins
pubmed
11000485
uniprot
proteins
pubmed
11675786
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11675786}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Y3Q4}.
uniprot
proteins
transmembrane_region
TRANSMEM 267..287; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 294..314; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 341..361; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 369..389; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 421..441; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 497..517; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins