SRGAP2C
entrez
653464
canonical
uniprot
P0DJJ0
canonical
ensembl
ENSG00000171943
resolver
ensp
ENSP00000478290
resolver
ensp
ENSP00000588196
resolver
ensp
ENSP00000656615
resolver
enst
ENST00000367123
resolver
enst
ENST00000918137
resolver
genesymbol
SRGAP2C
resolver
genesymbol_syn
SRGAP2P1
resolver
hgnc
HGNC:30584
resolver
uniprot_entry
SRG2C_HUMAN
resolver
amino_acid_sequence
MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAEHFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKWESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPCSPDSTANVRIEEKHVRRSSVKKIEKMKEKHQAKYTENKLKAIKAQNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTVRECYGF
uniprot
proteins
function
FUNCTION: Human-specific protein that acts as a key modifier of cortical connectivity in the human brain (PubMed:22559944, PubMed:27373832, PubMed:34707291). Acts by inhibiting the functions of ancestral paralog SRGAP2/SRGAP2A, a postsynaptic protein that regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2C is unstable but is able to heterodimerize with SRGAP2/SRGAP2A, thereby reducing SRGAP2/SRGAP2A levels through proteasome-dependent degradation (PubMed:27373832, PubMed:28333212, PubMed:31822692). Inhibition of SRGAP2/SRGAP2A by SRGAP2C leads to an increase in synaptic density and protracted synaptic maturation of both excitatory and inhibitory synapses (PubMed:27373832, PubMed:34707291). Modifies cortical circuit connectivity by increasing the number of local and long-range cortical inputs received by layer 2/3 pyramidal neurons (PubMed:34707291). Also able to increase the probability of sensory-evoked responses by layer 2/3 pyramidal neurons (PubMed:34707291). {ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212, ECO:0000269|PubMed:31822692, ECO:0000269|PubMed:34707291}.
uniprot
proteins
mass_dalton
53484
uniprot
proteins
mutagenesis
MUTAGEN 73; /note="H->R: Does not improve solubility; when associated with R-108, R-205, R-235 and R-250."; /evidence="ECO:0000269|PubMed:28333212"; MUTAGEN 108; /note="W->R: Does not improve solubility; when associated with R-73, R-205, R-235 and R-250."; /evidence="ECO:0000269|PubMed:28333212"; MUTAGEN 205; /note="C->R: Does not improve solubility; when associated with R-73, R-108, R-235 and R-250."; /evidence="ECO:0000269|PubMed:28333212"; MUTAGEN 235; /note="H->R: Does not improve solubility; when associated with R-73, R-108, R-205 and R-250."; /evidence="ECO:0000269|PubMed:28333212"; MUTAGEN 250; /note="Q->R: Does not improve solubility; when associated with R-73, R-108, R-205 and R-235."; /evidence="ECO:0000269|PubMed:28333212
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
22559943
uniprot
proteins
pubmed
22559944
uniprot
proteins
pubmed
27373832
uniprot
proteins
pubmed
28333212
uniprot
proteins
pubmed
28580430
uniprot
proteins
pubmed
31822692
uniprot
proteins
pubmed
34707291
uniprot
proteins
sequence_length
459
uniprot
proteins