Trpv2
entrez
29465
canonical
uniprot
Q9WUD2
canonical
ensembl
ENSRNOG00000003104
resolver
ensp
ENSRNOP00000004248
resolver
enst
ENSRNOT00000004248
resolver
genesymbol
Trpv2
resolver
genesymbol_syn
Sac2b
resolver
genesymbol_syn
Vrl1
resolver
uniprot
A0A0G2JSH6
resolver
uniprot
Q5FWT3
resolver
uniprot
Q9JMI8
resolver
uniprot
Q9QYH8
resolver
uniprot_entry
A0A0G2JSH6_RAT
resolver
uniprot_entry
TRPV2_RAT
resolver
uniprot_sec
Q5FWT3
resolver
uniprot_sec
Q9JMI8
resolver
uniprot_sec
Q9QYH8
resolver
activity_regulation
ACTIVITY REGULATION: Activated by temperatures higher than 52 degrees Celsius (PubMed:10201375). Weakly activated by cannabinoid that binds to the vanilloid binding pocket; this activation is potentiated by the binding of uricosuric agents like probenecid (PubMed:39972168). {ECO:0000269|PubMed:10201375, ECO:0000269|PubMed:39972168}.
uniprot
proteins
amino_acid_sequence
MTSASSPPAFRLETSDGDEEGNAEVNKGKQEPPPMESPFQREDRNSSPQIKVNLNFIKRPPKNTSAPSQQEPDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKLLVNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQREFSGPYQPLSRKFTEWCYGPVRVSLYDLSSVDSWEKNSVLEIIAFHCKSPNRHRMVVLEPLNKLLQEKWDRLVSRFFFNFACYLVYMFIFTVVAYHQPSLDQPAIPSSKATFGESMLLLGHILILLGGIYLLLGQLWYFWRRRLFIWISFMDSYFEILFLLQALLTVLSQVLRFMETEWYLPLLVLSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKAPEDNNSTVTEQPTVGQEEEPAPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNHVADNSWSIWKLQKAISVLEMENGYWWCRRKKHREGRLLKVGTRGDGTPDERWCFRVEEVNWAAWEKTLPTLSEDPSGPGITGNKKNPTSKPGKNSASEEDHLPLQVLQSP
uniprot
proteins
function
FUNCTION: Calcium-permeable, non-selective cation channel (PubMed:10201375, PubMed:15249591, PubMed:39972168). Seems to be regulated, at least in part, by growth factors, such as IGF1, PDGF and morphogenetic neuropeptide/head activator (By similarity). May transduce physical stimuli in mast cells (PubMed:15249591). {ECO:0000250|UniProtKB:Q9WTR1, ECO:0000269|PubMed:10201375, ECO:0000269|PubMed:15249591}.
uniprot
proteins
mass_dalton
86706
uniprot
proteins
mutagenesis
MUTAGEN 165; /note="H->Q: Inhibits TRPV2 activation."; /evidence="ECO:0000269|PubMed:39972168"; MUTAGEN 724; /note="E->A: Inhibits TRPV2 activation; when associated with A-725."; /evidence="ECO:0000269|PubMed:39972168"; MUTAGEN 725; /note="D->A: Inhibits TRPV2 activation; when associated with A-724."; /evidence="ECO:0000269|PubMed:39972168
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:14622291}.; PTM: Phosphorylated by PKA. {ECO:0000269|PubMed:15249591}.
uniprot
proteins
protein_family
TRPV2 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
protein_family
TrpV subfamily
uniprot
proteins
pubmed
10201375
uniprot
proteins
pubmed
14622291
uniprot
proteins
pubmed
14991772
uniprot
proteins
pubmed
15249591
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16809337
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
39972168
uniprot
proteins
sequence_length
761
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14622291, ECO:0000269|PubMed:14991772, ECO:0000269|PubMed:15249591}; Multi-pass membrane protein {ECO:0000269|PubMed:39972168}. Cytoplasm {ECO:0000250|UniProtKB:Q9WTR1}. Melanosome {ECO:0000250|UniProtKB:Q9Y5S1}. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation. {ECO:0000250|UniProtKB:Q9WTR1}.
uniprot
proteins
transmembrane_region
TRANSMEM 393..411; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:39972168, ECO:0007744|PDB:9B3U, ECO:0007744|PDB:9B3V, ECO:0007744|PDB:9B3W, ECO:0007744|PDB:9B3X, ECO:0007744|PDB:9B3Y, ECO:0007744|PDB:9B3Z"; TRANSMEM 432..454; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:39972168, ECO:0007744|PDB:9B3U, ECO:0007744|PDB:9B3V, ECO:0007744|PDB:9B3W, ECO:0007744|PDB:9B3X, ECO:0007744|PDB:9B3Y, ECO:0007744|PDB:9B3Z"; TRANSMEM 471..489; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:39972168, ECO:0007744|PDB:9B3U, ECO:0007744|PDB:9B3V, ECO:0007744|PDB:9B3W, ECO:0007744|PDB:9B3X, ECO:0007744|PDB:9B3Y, ECO:0007744|PDB:9B3Z"; TRANSMEM 496..516; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:39972168, ECO:0007744|PDB:9B3U, ECO:0007744|PDB:9B3V, ECO:0007744|PDB:9B3W, ECO:0007744|PDB:9B3X, ECO:0007744|PDB:9B3Y, ECO:0007744|PDB:9B3Z"; TRANSMEM 537..558; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:39972168, ECO:0007744|PDB:9B3U, ECO:0007744|PDB:9B3V, ECO:0007744|PDB:9B3W, ECO:0007744|PDB:9B3X, ECO:0007744|PDB:9B3Y, ECO:0007744|PDB:9B3Z"; TRANSMEM 621..641; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:39972168, ECO:0007744|PDB:9B3U, ECO:0007744|PDB:9B3V, ECO:0007744|PDB:9B3W, ECO:0007744|PDB:9B3X, ECO:0007744|PDB:9B3Y, ECO:0007744|PDB:9B3Z
uniprot
proteins