Cmklr1
entrez
14747
canonical
uniprot
P97468
canonical
ensembl
ENSMUSG00000042190
resolver
ensp
ENSMUSP00000036316
resolver
ensp
ENSMUSP00000121765
resolver
enst
ENSMUST00000047936
resolver
genesymbol
Cmklr1
resolver
genesymbol_syn
Dez
resolver
genesymbol_syn
Gpcr27
resolver
uniprot
Q497D3
resolver
uniprot_entry
CML1_MOUSE
resolver
uniprot_entry
Q497D3_MOUSE
resolver
amino_acid_sequence
MEYDAYNDSGIYDDEYSDGFGYFVDLEEASPWEAKVAPVFLVVIYSLVCFLGLLGNGLVIVIATFKMKKTVNTVWFVNLAVADFLFNIFLPMHITYAAMDYHWVFGKAMCKISNFLLSHNMYTSVFLLTVISFDRCISVLLPVWSQNHRSIRLAYMTCSAVWVLAFFLSSPSLVFRDTANIHGKITCFNNFSLAAPESSPHPAHSQVVSTGYSRHVAVTVTRFLCGFLIPVFIITACYLTIVFKLQRNRLAKNKKPFKIIITIIITFFLCWCPYHTLYLLELHHTAVPSSVFSLGLPLATAVAIANSCMNPILYVFMGHDFRKFKVALFSRLANALSEDTGPSSYPSHRSFTKMSSLNEKASVNEKETSTL
uniprot
proteins
function
FUNCTION: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B (By similarity). Positively regulates adipogenesis and adipocyte metabolism. {ECO:0000250, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:16863918, ECO:0000269|PubMed:17635925}.
uniprot
proteins
mass_dalton
41815
uniprot
proteins
protein_family
Chemokine-like receptor (CMKLR) family
uniprot
proteins
pubmed
15753205
uniprot
proteins
pubmed
16863918
uniprot
proteins
pubmed
17635925
uniprot
proteins
pubmed
17767914
uniprot
proteins
pubmed
18242188
uniprot
proteins
pubmed
19841182
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9144535
uniprot
proteins
sequence_length
371
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16863918}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..62; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 74..95; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 153..174; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 223..243; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 299..318; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins