HTR3A
entrez
3359
canonical
uniprot
P46098
canonical
ensembl
ENSG00000166736
resolver
ensp
ENSP00000299961
resolver
ensp
ENSP00000424189
resolver
ensp
ENSP00000424776
resolver
genesymbol
HTR3A
resolver
genesymbol_syn
5HT3R
resolver
genesymbol_syn
HTR3
resolver
hgnc
HGNC:5297
resolver
uniprot
B4DSY6
resolver
uniprot
B4E398
resolver
uniprot
G5E986
resolver
uniprot
O60854
resolver
uniprot
Q7KZM7
resolver
uniprot
Q99918
resolver
uniprot
Q9BSZ9
resolver
uniprot_entry
5HT3A_HUMAN
resolver
uniprot_entry
B4E398_HUMAN
resolver
uniprot_sec
B4DSY6
resolver
uniprot_sec
G5E986
resolver
uniprot_sec
O60854
resolver
uniprot_sec
Q7KZM7
resolver
uniprot_sec
Q99918
resolver
uniprot_sec
Q9BSZ9
resolver
amino_acid_sequence
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
uniprot
proteins
function
FUNCTION: Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons. {ECO:0000269|PubMed:10521471, ECO:0000269|PubMed:12867984, ECO:0000269|PubMed:17392525, ECO:0000269|PubMed:9950429}.
uniprot
proteins
mass_dalton
55280
uniprot
proteins
mutagenesis
MUTAGEN 178; /note="W->S: Abolished 5-hydroxytryptamine (serotonin) binding to the heteromeric receptor."; /evidence="ECO:0000269|PubMed:17392525"; MUTAGEN 432; /note="R->Q: Little effect on conductance. Massive increase of conductance; when associated with D-436 and A-440."; /evidence="ECO:0000269|PubMed:12867984"; MUTAGEN 436; /note="R->D: Increased conductance. Massive increase of conductance; when associated with Q-432 and A-440."; /evidence="ECO:0000269|PubMed:12867984"; MUTAGEN 440; /note="R->A: Increased conductance. Massive increase of conductance; when associated with Q-432 and D-436."; /evidence="ECO:0000269|PubMed:12867984
uniprot
proteins
protein_family
5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily
uniprot
proteins
protein_family
HTR3A sub-subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
10521471
uniprot
proteins
pubmed
10670426
uniprot
proteins
pubmed
12867984
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15028279
uniprot
proteins
pubmed
15293096
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15809299
uniprot
proteins
pubmed
16487942
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17392525
uniprot
proteins
pubmed
7565620
uniprot
proteins
pubmed
8848005
uniprot
proteins
pubmed
9928262
uniprot
proteins
pubmed
9950429
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:9950429}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23979}. Cell membrane {ECO:0000305|PubMed:9950429}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23979}.
uniprot
proteins
transmembrane_region
TRANSMEM 242..268; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 274..292; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 303..321; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 456..475; /note="Helical; Name=4"; /evidence="ECO:0000255
uniprot
proteins