Cops9
entrez
66915
canonical
uniprot
Q3U898
canonical
ensembl
ENSMUSG00000073616
resolver
ensp
ENSMUSP00000095247
resolver
enst
ENSMUST00000097642
resolver
genesymbol
Cops9
resolver
genesymbol_syn
Myeov2
resolver
uniprot
B2RVT1
resolver
uniprot_entry
B2RVT1_MOUSE
resolver
uniprot_entry
CSN9_MOUSE
resolver
amino_acid_sequence
MKPAVDEMFPEGAGPYVDLDEAGGSTGLLMDLAANEKAVHADFFNDFEDLFDDDDVQ
uniprot
proteins
function
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation. {ECO:0000250|UniProtKB:Q8WXC6}.
uniprot
proteins
mass_dalton
6197
uniprot
proteins
protein_family
CSN9 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
57
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WXC6}. Cytoplasm {ECO:0000250|UniProtKB:Q8WXC6}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q8WXC6}. Note=Excluded from the nucleolus. Recruited to the nucleoplasm and chromatin following DNA damage induction. {ECO:0000250|UniProtKB:Q8WXC6}.
uniprot
proteins