Tmem59
entrez
56374
canonical
uniprot
Q9QY73
canonical
ensembl
ENSMUSG00000028618
resolver
ensp
ENSMUSP00000030361
resolver
enst
ENSMUST00000030361
resolver
genesymbol
Tmem59
resolver
genesymbol_syn
ORF18
resolver
genesymbol_syn
Tdcf1
resolver
uniprot
Q3TWB4
resolver
uniprot
Q99LY8
resolver
uniprot
Q9D1P9
resolver
uniprot_entry
TMM59_MOUSE
resolver
uniprot_sec
Q3TWB4
resolver
uniprot_sec
Q99LY8
resolver
uniprot_sec
Q9D1P9
resolver
amino_acid_sequence
MAAPKGKLWVQAQLGLPPLLLLTMALAGGSGTAAAEAFDSVLGDTASCHRACQLTYPLHTYPKEEELYACQRGCRLFSICQFVDDGLDLNRTKLECESACTEAYSQPDEQYACHLGCQDQLPFAELRQEQLMSLMPRMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIFQSKPEIQYAPQLEQEPTNLRESSLSKMSYLQMRNSQAHRNYLEEEESDGFLRCLSLNSGWILTTTLVLSVMVLLWICCAAVATAVEQYVPPEKLSIYGDLEFMNEQKLSRYPAPSLVIVRSQTEEHEEAGPLPTKVNLAHSEI
uniprot
proteins
function
FUNCTION: Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. {ECO:0000250|UniProtKB:Q9BXS4}.
uniprot
proteins
mass_dalton
36314
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9BXS4}.
uniprot
proteins
protein_family
TMEM59 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:Q9BXS4}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q9BXS4}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9BXS4}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9BXS4}; Single-pass type I membrane protein {ECO:0000255}. Note=Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded. {ECO:0000250|UniProtKB:Q9BXS4}.
uniprot
proteins
transmembrane_region
TRANSMEM 239..259; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins