HOMER3
entrez
9454
canonical
uniprot
Q9NSC5
canonical
ensembl
ENSG00000051128
resolver
ensp
ENSP00000376162
resolver
ensp
ENSP00000396154
resolver
ensp
ENSP00000446026
resolver
ensp
ENSP00000471835
resolver
genesymbol
HOMER3
resolver
hgnc
HGNC:17514
resolver
uniprot
B2RA10
resolver
uniprot
E9PCW9
resolver
uniprot
O14580
resolver
uniprot
O95350
resolver
uniprot
Q9NSB9
resolver
uniprot
Q9NSC0
resolver
uniprot
Q9NSC1
resolver
uniprot_entry
HOME3_HUMAN
resolver
uniprot_sec
B2RA10
resolver
uniprot_sec
E9PCW9
resolver
uniprot_sec
O14580
resolver
uniprot_sec
O95350
resolver
uniprot_sec
Q9NSB9
resolver
uniprot_sec
Q9NSC0
resolver
uniprot_sec
Q9NSC1
resolver
amino_acid_sequence
MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAAP
uniprot
proteins
function
FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901}.
uniprot
proteins
mass_dalton
39836
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="A->N: Does not affect interaction with NFATC2. Decreases interaction with NFATC2; when associated with 53-L--S-56. Decreases interaction with NFATC2; when associated with S-43 and 53-L--S-56. Markedly decreases interaction with NFATC2; when associated with T-30 and S-31 and 53-L--S-56. Impairs interaction with NFATC2; when associated with T-30; S-31; S-43 and 53-L--S-56."; /evidence="ECO:0000269|PubMed:18218901"; MUTAGEN 30..31; /note="AG->TS: Markedly decreases interaction with NFATC2; when associated with S-43 and 53-L--S-56. Markedly decreases interaction with NFATC2; when associated with N-22 and 53-L--S-56. Impairs interaction with NFATC2; when associated with N-22; S-43 and 53-L--S-56."; /evidence="ECO:0000269|PubMed:18218901"; MUTAGEN 36; /note="T->A: Does not affect interaction with NFATC2; when associated with A-38 and A-52. Attenuates inhibition by AKT; when associated with A-38 and A-52."; /evidence="ECO:0000269|PubMed:18218901"; MUTAGEN 38; /note="S->A: Does not affect interaction with NFATC2; when associated with A-36 and A-52. Attenuates inhibition by AKT; when associated with A-36 and A-52."; /evidence="ECO:0000269|PubMed:18218901"; MUTAGEN 43; /note="A->S: Does not affect interaction with NFATC2. Decreases interaction with NFATC2; when associated with N-22 and 53-L--S-56. Markedly decreases interaction with NFATC2; when associated with T-30; S-31 and 53-L--S-56. Impairs interaction with NFATC2; when associated with N-22; T-30; S-31 and 53-L--S-56."; /evidence="ECO:0000269|PubMed:18218901"; MUTAGEN 52; /note="S->A: Does not affect interaction with NFATC2; when associated with A-36 and A-38. Attenuates inhibition by AKT; when associated with A-36 and A-38."; /evidence="ECO:0000269|PubMed:18218901"; MUTAGEN 53..56; /note="IGGA->LDGS: Decreases interaction with NFATC2. Decreases interaction with NFATC2; when associated with N-22. Decreases interaction with NFATC2; when associated with N-22 and S-43. Markedly decreases interaction with NFATC2; when associated with T-30; S-31 and S-43. Markedly decreases interaction with NFATC2; when associated with N-22; T-30 and S-31. Impairs interaction with NFATC2; when associated with N-22; T-30, S-31 and S-43."; /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:18218901"; MUTAGEN 54; /note="G->D: Decreases interaction with NFATC2."; /evidence="ECO:0000269|PubMed:15489334
uniprot
proteins
protein_family
Homer family
uniprot
proteins
pubmed
10653696
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18218901
uniprot
proteins
pubmed
19345194
uniprot
proteins
pubmed
9808458
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}. Note=Postsynaptic density of neuronal cells. {ECO:0000250}.
uniprot
proteins