Rufy3
entrez
52822
canonical
uniprot
Q9D394
canonical
ensembl
ENSMUSG00000029291
resolver
ensp
ENSMUSP00000031229
resolver
ensp
ENSMUSP00000143115
resolver
ensp
ENSMUSP00000143209
resolver
ensp
ENSMUSP00000143302
resolver
ensp
ENSMUSP00000143770
resolver
ensp
ENSMUSP00000198637
resolver
ensp
ENSMUSP00000198643
resolver
enst
ENSMUST00000198965
resolver
genesymbol
Rufy3
resolver
genesymbol_syn
D5Bwg0860e
resolver
genesymbol_syn
Ripx
resolver
uniprot
A0A0G2JFT8
resolver
uniprot
Q3U348
resolver
uniprot
Q3UF96
resolver
uniprot
Q6PE64
resolver
uniprot
Q8VD10
resolver
uniprot_entry
A0A0G2JFT8_MOUSE
resolver
uniprot_entry
RUFY3_MOUSE
resolver
uniprot_sec
Q3U348
resolver
uniprot_sec
Q3UF96
resolver
uniprot_sec
Q6PE64
resolver
uniprot_sec
Q8VD10
resolver
amino_acid_sequence
MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEVNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGSEGDGQITAILDQKNYVEELNRHLNATVNNLQTKVDLLEKSNTKLTEELAVANNRIITLQEEMERVKEESSYLLESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELELQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPKHH
uniprot
proteins
function
FUNCTION: ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma (By similarity). Plays a role in the generation of neuronal polarity formation and axon growth (PubMed:24720729). Implicated in the formation of a single axon by developing neurons (PubMed:24720729). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (By similarity). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (PubMed:24720729). {ECO:0000250|UniProtKB:Q5FVJ0, ECO:0000250|UniProtKB:Q7L099, ECO:0000269|PubMed:24720729}.
uniprot
proteins
mass_dalton
53007
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PAK1. Isoform 1 is partially phosphorylated. {ECO:0000250|UniProtKB:Q5FVJ0, ECO:0000250|UniProtKB:Q7L099}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
16928684
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24720729
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7L099}. Endomembrane system {ECO:0000250|UniProtKB:Q7L099}. Cell projection, invadopodium {ECO:0000250|UniProtKB:Q7L099}. Cell projection, growth cone {ECO:0000269|PubMed:24720729}. Perikaryon {ECO:0000269|PubMed:24720729}. Cell projection {ECO:0000269|PubMed:24720729}. Cell projection, filopodium {ECO:0000269|PubMed:24720729}. Cell projection, lamellipodium {ECO:0000269|PubMed:24720729}. Lysosome {ECO:0000250|UniProtKB:Q7L099}. Note=Colocalizes with PAK1, F-actin, myosins and integrins in invadopodia at the cell periphery (By similarity). Colocalizes with Ras-related Rab-5 proteins in cytoplasmic vesicles (By similarity). Accumulates in axon growth cones in a F-actin-dependent manner (PubMed:24720729). Colocalizes with FSCN1 and F-actin at filipodia and lamellipodia of axonal growth cones (PubMed:24720729). Colocalizes with DBN1 and F-actin at transitional domain of the axonal growth cone (PubMed:24720729). Recruitment to endolysosomes partially depends upon the presence of ARL8 (By similarity). {ECO:0000250|UniProtKB:Q5FVJ0, ECO:0000250|UniProtKB:Q7L099, ECO:0000269|PubMed:24720729}.
uniprot
proteins