Ddr1
entrez
12305
canonical
uniprot
Q03146
canonical
ensembl
ENSMUSG00000003534
resolver
ensp
ENSMUSP00000094945
resolver
ensp
ENSMUSP00000112570
resolver
ensp
ENSMUSP00000113062
resolver
ensp
ENSMUSP00000133047
resolver
ensp
ENSMUSP00000166418
resolver
ensp
ENSMUSP00000166425
resolver
ensp
ENSMUSP00000325736
resolver
ensp
ENSMUSP00000364970
resolver
genesymbol
Ddr1
resolver
genesymbol_syn
Cak
resolver
genesymbol_syn
Eddr1
resolver
genesymbol_syn
Mpk6
resolver
uniprot
Q05BN5
resolver
uniprot
Q544T2
resolver
uniprot_entry
DDR1_MOUSE
resolver
uniprot_entry
Q05BN5_MOUSE
resolver
uniprot_entry
Q544T2_MOUSE
resolver
amino_acid_sequence
MGTGTLSSLLLLLLLVTIGDADMKGHFDPAKCRYALGMQDRTIPDSDISVSSSWSDSTAARHSRLESSDGDGAWCPAGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMQLSEVMVHLNDSTYDGYTAGGLQYGGLGQLADGVVGLDDFRQSQELRVWPGYDYVGWSNQSFPTGYVEMEFEFDRLRTFQTMQVHCNNMHTLGARLPGGVECRFKRGPAMAWEGEPVRHALGGSLGDPRARAISVPLGGHVGRFLQCRFLFAGPWLLFSEISFISDVVNDSSDTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPREPPPYQEPRPRGTPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNTQACSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSARQLENKATQGLSGDTESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFAQLHRFLADDALNTV
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (By similarity). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. {ECO:0000250, ECO:0000269|PubMed:12065315}.
uniprot
proteins
mass_dalton
101161
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated in response to fibrillar collagen binding. {ECO:0000250}.
uniprot
proteins
protein_family
Insulin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
11283268
uniprot
proteins
pubmed
12065315
uniprot
proteins
pubmed
1281307
uniprot
proteins
pubmed
15200417
uniprot
proteins
pubmed
18026164
uniprot
proteins
pubmed
8622863
uniprot
proteins
sequence_length
911
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 416..436; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins