Cyp2c22
entrez
171518
canonical
uniprot
P19225
canonical
ensembl
ENSRNOG00000021924
resolver
ensembl
ENSRNOG00055028865
resolver
ensembl
ENSRNOG00060024351
resolver
ensembl
ENSRNOG00065030141
resolver
ensp
ENSRNOP00000051607
resolver
ensp
ENSRNOP00055041169
resolver
ensp
ENSRNOP00060034950
resolver
ensp
ENSRNOP00065042828
resolver
enst
ENSRNOT00000054724
resolver
enst
ENSRNOT00055050001
resolver
enst
ENSRNOT00060042148
resolver
enst
ENSRNOT00065052030
resolver
genesymbol
Cyp2c22
resolver
genesymbol
Cyp2c70
resolver
genesymbol_syn
Cyp2c-70
resolver
genesymbol_syn
Cyp2c22
resolver
genesymbol_syn
P450md
resolver
uniprot
B5AMZ7
resolver
uniprot_entry
B5AMZ7_RAT
resolver
uniprot_entry
CP270_RAT
resolver
amino_acid_sequence
MALFIFLGIWLSCLVFLFLWNQHHVRRKLPPGPTPLPIFGNILQVGVKNISKSMCMLAKEYGPVFTMYLGMKPTVVLYGYEVLKEALIDRGEEFSDKMHSSMLSKVSQGLGIVFSNGEIWKQTRRFSLMVLRSMGMGKRTIENRIQEEVVYLLEALRKTNGSPCDPSFLLACVPCNVISSVIFQHRFDYSDEKFQKFIENFHTKIEILASPWAQLCSAYPVLYYLPGIHNKFLKDVTEQKKFILMEINRHRASLNLSNPQDFIDYFLIKMEKEKHNEKSEFTMDNLIVTIGDLFGAGTETTSSTIKYGLLLLLKYPEVTAKIQEEITRVIGRHRRPCMQDRNHMPYTDAVLHEIQRYIDFVPIPLPRKTTQDVEFRGYHIPKGTSVMACLTSALHDDKEFPNPEKFDPGHFLDEKGNFKKSDYFMAFSAGRRACIGEGLARMEMFLILTSILQHFTLKPLVNPEDIDTTPVQPGLLSVPPPFELCFIPV
uniprot
proteins
ec_number
1.14.14.-
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in muricholic acid (MCA) synthesis. Hydroxylates at the 6-beta position two major bile acids, chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) to form alpha-MCA and beta-MCA, respectively. May regulate NR1H4/farnesoid X receptor signaling, as taurine-conjugated MCAs are antagonists of NR1H4. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). {ECO:0000250|UniProtKB:Q91W64}.
uniprot
proteins
mass_dalton
56157
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
2263625
uniprot
proteins
pubmed
2395662
uniprot
proteins
sequence_length
489
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
uniprot
proteins