Nampt
entrez
59027
canonical
uniprot
Q99KQ4
canonical
ensembl
ENSMUSG00000020572
resolver
ensp
ENSMUSP00000020886
resolver
enst
ENSMUST00000020886
resolver
genesymbol
Nampt
resolver
genesymbol_syn
Pbef1
resolver
uniprot
Q8C3B5
resolver
uniprot
Q9JKM0
resolver
uniprot_entry
NAMPT_MOUSE
resolver
uniprot_sec
Q8C3B5
resolver
uniprot_sec
Q9JKM0
resolver
amino_acid_sequence
MNAAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKVRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKEVYREHFQDDVFNERGWNYILEKYDGHLPIEVKAVPEGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGIALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTEAPLIIRPDSGNPLDTVLKVLDILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKKWSIENVSFGSGGALLQKLTRDLLNCSFKCSYVVTNGLGVNVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGHDLLHTVFKNGKVTKSYSFDEVRKNAQLNIEQDVAPH
uniprot
proteins
ec_number
2.4.2.12
uniprot
proteins
function
FUNCTION: The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma (By similarity). Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. {ECO:0000250|UniProtKB:P43490, ECO:0000269|PubMed:12555668, ECO:0000269|PubMed:15381699, ECO:0000269|PubMed:19286518, ECO:0000269|PubMed:19299583}.
uniprot
proteins
mass_dalton
55447
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.
uniprot
proteins
protein_family
NAPRTase family
uniprot
proteins
pubmed
12555668
uniprot
proteins
pubmed
15381699
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16783373
uniprot
proteins
pubmed
16783377
uniprot
proteins
pubmed
19286518
uniprot
proteins
pubmed
19299583
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P43490}. Cytoplasm {ECO:0000269|PubMed:12555668}. Secreted {ECO:0000250|UniProtKB:P43490}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000250|UniProtKB:P43490}.
uniprot
proteins