Nsmce1
entrez
67711
canonical
uniprot
Q9D720
canonical
ensembl
ENSMUSG00000030750
resolver
ensp
ENSMUSP00000033006
resolver
ensp
ENSMUSP00000323310
resolver
ensp
ENSMUSP00000323312
resolver
ensp
ENSMUSP00000323313
resolver
ensp
ENSMUSP00000323314
resolver
ensp
ENSMUSP00000323315
resolver
ensp
ENSMUSP00000345685
resolver
ensp
ENSMUSP00000345687
resolver
ensp
ENSMUSP00000352317
resolver
ensp
ENSMUSP00000352321
resolver
enst
ENSMUST00000033006
resolver
genesymbol
Nsmce1
resolver
uniprot
A0A0R4J0C0
resolver
uniprot
Q3TLN4
resolver
uniprot
Q8K2B4
resolver
uniprot
Q9CY20
resolver
uniprot_entry
A0A0R4J0C0_MOUSE
resolver
uniprot_entry
NSE1_MOUSE
resolver
uniprot_sec
Q3TLN4
resolver
uniprot_sec
Q8K2B4
resolver
uniprot_sec
Q9CY20
resolver
amino_acid_sequence
MQGSTRRAGAMTDVHRRFLQLLMTHGVLEEWEVRRLQNHCYQVHDRNATVDKLEDFINNINSVLESLYIEIKKGVTEDDGRPIYALVNLATTSVSKMATDFAENELDLFRKALELIVDSETGFASSTNILNLVDQLKGKKMRKKEAEQVLQKFVQSKWLIEKEGEFTLHGRAILEMEQFIRESYPDSVKMCNICHGLLIQGQSCETCGIRMHLPCVAKYFQSIPEPHCPHCNDYWPHDIPEVYNPEKEREAGISKSSRKSLRTRQH
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair. {ECO:0000250|UniProtKB:Q8WV22}.
uniprot
proteins
mass_dalton
30708
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. {ECO:0000250|UniProtKB:Q8WV22}.
uniprot
proteins
protein_family
NSE1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WV22}. Chromosome, telomere {ECO:0000250|UniProtKB:Q8WV22}.
uniprot
proteins