BTG2
entrez
7832
canonical
uniprot
P78543
canonical
ensembl
ENSG00000159388
resolver
ensp
ENSP00000290551
resolver
ensp
ENSP00000433553
resolver
enst
ENST00000290551
resolver
enst
ENST00000475157
resolver
genesymbol
BTG2
resolver
genesymbol_syn
PC3
resolver
hgnc
HGNC:1131
resolver
uniprot
A0A024R986
resolver
uniprot
Q3KR25
resolver
uniprot
Q5VUT0
resolver
uniprot_entry
BTG2_HUMAN
resolver
uniprot_sec
A0A024R986
resolver
uniprot_sec
Q3KR25
resolver
uniprot_sec
Q5VUT0
resolver
amino_acid_sequence
MSHGKGTDMLPEIAAAVGFLSSLLRTRGCVSEQRLKVFSGALQEALTEHYKHHWFPEKPSKGSGYRCIRINHKMDPIISRVASQIGLSQPQLHQLLPSELTLWVDPYEVSYRIGEDGSICVLYEEAPLAASCGLLTCKNQVLLGRSSPSKNYVMAVSS
uniprot
proteins
function
FUNCTION: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth. {ECO:0000250, ECO:0000269|PubMed:12771185, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:18337750, ECO:0000269|PubMed:18773938, ECO:0000269|PubMed:23236473}.
uniprot
proteins
mass_dalton
17416
uniprot
proteins
mutagenesis
MUTAGEN 53; /note="H->A: Impairs interaction with CNOT7 and CNOT8."; /evidence="ECO:0000269|PubMed:23236473"; MUTAGEN 65; /note="Y->A: Abolishes interaction with CNOT7 and CNOT8."; /evidence="ECO:0000269|PubMed:18974182, ECO:0000269|PubMed:23236473"; MUTAGEN 75; /note="D->A: Abolishes interaction with CNOT7 and CNOT8."; /evidence="ECO:0000269|PubMed:23236473"; MUTAGEN 103; /note="W->A: Abolishes interaction with CNOT7 and CNOT8; impairs anti-proliferative activity."; /evidence="ECO:0000269|PubMed:18974182, ECO:0000269|PubMed:23236473"; MUTAGEN 105; /note="D->A: Impairs interaction with CNOT7 and CNOT8."; /evidence="ECO:0000269|PubMed:23236473"; MUTAGEN 115; /note="E->A: Impairs interaction with CNOT7. Inhibits CNOT7 mRNA deadenylase activity."; /evidence="ECO:0000269|PubMed:18974182"; MUTAGEN 147; /note="S->A: Impairs phosphorylation by MAPK1 and MAPK3, and decreases PIN1-binding."; /evidence="ECO:0000269|PubMed:15788397"; MUTAGEN 148; /note="P->A: Impairs PIN1-binding."; /evidence="ECO:0000269|PubMed:15788397"; MUTAGEN 149; /note="S->A: Impairs phosphorylation by MAPK14, and decreases PIN1-binding."; /evidence="ECO:0000269|PubMed:15788397
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization. {ECO:0000269|PubMed:15788397}.
uniprot
proteins
protein_family
BTG family
uniprot
proteins
pubmed
11136725
uniprot
proteins
pubmed
11267995
uniprot
proteins
pubmed
11814693
uniprot
proteins
pubmed
12771185
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15788397
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18337750
uniprot
proteins
pubmed
18773938
uniprot
proteins
pubmed
18974182
uniprot
proteins
pubmed
23236473
uniprot
proteins
pubmed
8944033
uniprot
proteins
pubmed
9712883
uniprot
proteins
sequence_length
158
uniprot
proteins