Tmt1b
entrez
71664
canonical
uniprot
Q9DD20
canonical
ensembl
ENSMUSG00000025347
resolver
ensp
ENSMUSP00000026398
resolver
enst
ENSMUST00000026398
resolver
genesymbol
Tmt1b
resolver
genesymbol_syn
Mettl7b
resolver
uniprot
Q78ID2
resolver
uniprot_entry
TMT1B_MOUSE
resolver
uniprot_sec
Q78ID2
resolver
amino_acid_sequence
MDALVLFLQLLVLLLTLPLHLLALLGCWQPICKTYFPYFMAMLTARSYKKMESKKRELFSQIKDLKGTSGNVALLELGCGTGANFQFYPQGCKVTCVDPNPNFEKFLTKSMAENRHLQYERFIVAYGENMKQLADSSMDVVVCTLVLCSVQSPRKVLQEVQRVLRPGGLLFFWEHVAEPQGSRAFLWQRVLEPTWKHIGDGCHLTRETWKDIERAQFSEVQLEWQPPPFRWLPVGPHIMGKAVK
uniprot
proteins
ec_number
2.1.1.9
uniprot
proteins
function
FUNCTION: Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Selectively methylates S-centered nucleophiles from metabolites such as hydrogen sulfide and dithiothreitol. {ECO:0000250|UniProtKB:Q6UX53}.
uniprot
proteins
mass_dalton
28049
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q562C4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q562C4}. Lipid droplet {ECO:0000250|UniProtKB:Q562C4}. Microsome {ECO:0000250|UniProtKB:Q6UX53}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6UX53}. Note=Highly concentrated in the perinuclear area of the endoplasmic reticulum (ER) and surrounding lipid droplets. May be associated with the specific regions of the LR that form lipid droplets and targeted to the initial deposits of lipids where the lipid droplets form. {ECO:0000250|UniProtKB:Q562C4}.
uniprot
proteins