AZI2
entrez
64343
canonical
uniprot
Q9H6S1
canonical
ensembl
ENSG00000163512
resolver
ensp
ENSP00000335609
resolver
ensp
ENSP00000391696
resolver
ensp
ENSP00000419371
resolver
ensp
ENSP00000559326
resolver
ensp
ENSP00000559327
resolver
ensp
ENSP00000628237
resolver
genesymbol
AZI2
resolver
genesymbol_syn
NAP1
resolver
genesymbol_syn
TBKBP2
resolver
hgnc
HGNC:24002
resolver
uniprot
A8K3M2
resolver
uniprot
C9JB40
resolver
uniprot
H7BXU6
resolver
uniprot
Q86W99
resolver
uniprot
Q9BQF1
resolver
uniprot_entry
AZI2_HUMAN
resolver
uniprot_sec
A8K3M2
resolver
uniprot_sec
C9JB40
resolver
uniprot_sec
H7BXU6
resolver
uniprot_sec
Q86W99
resolver
uniprot_sec
Q9BQF1
resolver
amino_acid_sequence
MDALVEDDICILNHEKAHKRDTVTPVSIYSGDESVASHFALVTAYEDIKKRLKDSEKENSLLKKRIRFLEEKLIARFEEETSSVGREQVNKAYHAYREVCIDRDNLKSKLDKMNKDNSESLKVLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSNWEVEKLSCDLKIHGLEQELELMRKECSDLKIELQKAKQTDPYQEDNLKSRDLQKLSISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIKKACAPVGCSEDLGRDSTKLHLMNFTATYTRHPPLLPNGKALCHTTSSPLPGDVKVLSEKAILQSWTDNERSIPNDGTCFQEHSSYGRNSLEDNSWVFPSPPKSSETAFGETKTKTLPLPNLPPLHYLDQHNQNCLYKN
uniprot
proteins
function
FUNCTION: Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (PubMed:14560022, PubMed:21931631). Promotes TBK1-induced as well as TNF or PMA-induced activation of NF-kappa-B (PubMed:14560022, PubMed:21931631). Participates in IFNB promoter activation via TICAM1 (PubMed:15611223). {ECO:0000269|PubMed:14560022, ECO:0000269|PubMed:15611223, ECO:0000269|PubMed:21931631}.
uniprot
proteins
mass_dalton
44935
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated via 'Lys-48'-linked polyubiquitination by TRIM38, leading to its degradation. {ECO:0000250|UniProtKB:Q9QYP6}.
uniprot
proteins
pubmed
14560022
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15611223
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17568778
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
21931555
uniprot
proteins
pubmed
21931631
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29251827
uniprot
proteins
pubmed
30459273
uniprot
proteins
sequence_length
392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14560022}.
uniprot
proteins