CTSF
entrez
8722
canonical
uniprot
Q9UBX1
canonical
ensembl
ENSG00000174080
resolver
ensp
ENSP00000310832
resolver
enst
ENST00000310325
resolver
genesymbol
CTSF
resolver
hgnc
HGNC:2531
resolver
uniprot
B2R964
resolver
uniprot
O95240
resolver
uniprot
Q9NSU4
resolver
uniprot
Q9UKQ5
resolver
uniprot_entry
CATF_HUMAN
resolver
uniprot_sec
B2R964
resolver
uniprot_sec
O95240
resolver
uniprot_sec
Q9NSU4
resolver
uniprot_sec
Q9UKQ5
resolver
amino_acid_sequence
MAPWLQLLSLLGLLPGAVAAPAQPRAASFQAWGPPSPELLAPTRFALEMFNRGRAAGTRAVLGLVRGRVRRAGQGSLYSLEATLEEPPCNDPMVCRLPVSKKTLLCSFQVLDELGRHVLLRKDCGPVDTKVPGAGEPKSAFTQGSAMISSLSQNHPDNRNETFSSVISLLNEDPLSQDLPVKMASIFKNFVITYNRTYESKEEARWRLSVFVNNMVRAQKIQALDRGTAQYGVTKFSDLTEEEFRTIYLNTLLRKEPGNKMKQAKSVGDLAPPEWDWRSKGAVTKVKDQGMCGSCWAFSVTGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLPSNAYSAIKNLGGLETEDDYSYQGHMQSCNFSAEKAKVYINDSVELSQNEQKLAAWLAKRGPISVAINAFGMQFYRHGISRPLRPLCSPWLIDHAVLLVGYGNRSDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASSAVVD
uniprot
proteins
disease_involvement
DISEASE: Ceroid lipofuscinosis, neuronal, 13 (Kufs type) (CLN13) [MIM:615362]: A form of neuronal ceroid lipofuscinosis characterized by adult onset of progressive cognitive decline and motor dysfunction leading to dementia and often early death. Some patients develop seizures. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. CLN13 inheritance is autosomal recessive. {ECO:0000269|PubMed:23297359}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.22.41
uniprot
proteins
function
FUNCTION: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
uniprot
proteins
mass_dalton
53366
uniprot
proteins
protein_family
Peptidase C1 family
uniprot
proteins
pubmed
10198209
uniprot
proteins
pubmed
10318784
uniprot
proteins
pubmed
10362521
uniprot
proteins
pubmed
10661872
uniprot
proteins
pubmed
12225749
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
23297359
uniprot
proteins
pubmed
9822672
uniprot
proteins
sequence_length
484
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome.
uniprot
proteins