Nectin4
entrez
71740
canonical
uniprot
Q8R007
canonical
ensembl
ENSMUSG00000006411
resolver
ensp
ENSMUSP00000006578
resolver
ensp
ENSMUSP00000091883
resolver
genesymbol
Nectin4
resolver
genesymbol_syn
Lnir
resolver
genesymbol_syn
Prr4
resolver
genesymbol_syn
Pvrl4
resolver
uniprot
Q3U318
resolver
uniprot
Q8CED8
resolver
uniprot
Q9DBP8
resolver
uniprot_entry
NECT4_MOUSE
resolver
uniprot_sec
Q3U318
resolver
uniprot_sec
Q8CED8
resolver
uniprot_sec
Q9DBP8
resolver
amino_acid_sequence
MPLSLGAEMWGPEAWLRLLFLASFTGQYSAGELETSDVVTVVLGQDAKLPCFYRGDPDEQVGQVAWARVDPNEGIRELALLHSKYGLHVNPAYEDRVEQPPPPRDPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARMRLRVLVPPLPSLNPGPPLEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTQSSRSFTHPRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDRRITHTLQVAFLAEASVRGLEDQNLWQVGREGATLKCLSEGQPPPKYNWTRLDGPLPSGVRVKGDTLGFPPLTTEHSGVYVCHVSNELSSRDSQVTVEVLDPEDPGKQVDLVSASVIIVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHSDPRSQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRTEEDDDQDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV
uniprot
proteins
function
FUNCTION: Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Plays a role in the senescence-associated cell size enlargement via SFK/PI3K/Rac1 and thus promotes senescent cell survival. Also participates in the innate immune response by acting as a ligand for the receptor TIGIT to inhibit NK-cell activity. {ECO:0000250|UniProtKB:Q96NY8}.
uniprot
proteins
mass_dalton
55657
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
11544254
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
508
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96NY8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q96NY8}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q96NY8}. Note=Colocalizes with AFDN at cadherin-based adherens junctions. {ECO:0000250|UniProtKB:Q96NY8}.
uniprot
proteins
transmembrane_region
TRANSMEM 348..368; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins