Egr2
entrez
114090
canonical
uniprot
P51774
canonical
ensembl
ENSRNOG00000000640
resolver
ensembl
ENSRNOG00055009728
resolver
ensembl
ENSRNOG00060003248
resolver
ensembl
ENSRNOG00065022825
resolver
ensp
ENSRNOP00000000792
resolver
genesymbol
Egr2
resolver
genesymbol_syn
Egr-2
resolver
genesymbol_syn
Krox-20
resolver
genesymbol_syn
Krox20
resolver
uniprot
Q54AG4
resolver
uniprot_entry
EGR2_RAT
resolver
uniprot_sec
Q54AG4
resolver
amino_acid_sequence
MMTAKAVDKIPVTLSGFMHQLPDSLYPVEDLAAPSVTIFPNGELGGPFDQMNGVAGDGMINIDMTGEKRPLDLPYPSSFAPISAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTPPASTTASSSVTSASPNPLATGPLGVCTMSQTQPELDHLYSPPPPPPPYSGCTGDLYQDPSAFLSPPPTTSTSSLAYQPPPSYPSPKPAMDPGLIPMIPDYPGFFPSPCQRDPHGAAGPDRKPFPCPLDSLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGGEGPRLPGSGSAAVTATPYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSSSASAQSSASGPGGSQAGGSLCGNSAIGGPLASCTSRTRTP
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
function
FUNCTION: Sequence-specific DNA-binding transcription factor (By similarity). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity). Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity). {ECO:0000250|UniProtKB:P08152}.; FUNCTION: E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity. {ECO:0000250|UniProtKB:P11161}.
uniprot
proteins
mass_dalton
49849
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein sumoylation.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by WWP2 leading to proteasomal degradation. {ECO:0000250|UniProtKB:P08152}.; PTM: Acetylated at Lys-247. May be deacetylated by HDAC6, HDAC10 or SIRT1. {ECO:0000250|UniProtKB:P08152}.
uniprot
proteins
protein_family
EGR C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
10970821
uniprot
proteins
pubmed
8619872
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P08152}.
uniprot
proteins