Kidins220
entrez
116478
canonical
uniprot
Q9EQG6
canonical
ensembl
ENSRNOG00000023176
resolver
ensp
ENSRNOP00000005858
resolver
ensp
ENSRNOP00000063889
resolver
ensp
ENSRNOP00000085209
resolver
ensp
ENSRNOP00000092341
resolver
ensp
ENSRNOP00000093485
resolver
enst
ENSRNOT00000005858
resolver
enst
ENSRNOT00000066593
resolver
enst
ENSRNOT00000106831
resolver
enst
ENSRNOT00000119137
resolver
genesymbol
Kidins220
resolver
genesymbol_syn
Arms
resolver
uniprot
A0A0H4T4D0
resolver
uniprot
A0A8I6AFW6
resolver
uniprot
A0A8I6AHD1
resolver
uniprot
D3ZWB2
resolver
uniprot
D4ABK9
resolver
uniprot
Q9ERD4
resolver
uniprot_entry
A0A0H4T4D0_RAT
resolver
uniprot_entry
A0A8I6AFW6_RAT
resolver
uniprot_entry
A0A8I6AHD1_RAT
resolver
uniprot_entry
D3ZWB2_RAT
resolver
uniprot_entry
D4ABK9_RAT
resolver
uniprot_entry
KDIS_RAT
resolver
uniprot_sec
Q9ERD4
resolver
amino_acid_sequence
MSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMLAAEQGNVEIVKELLKNGANCNLEDLDNWTALISASKEGHIHIVEELLKSGASLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHIEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHVAIRGRSRRLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQTEPLFQFSWLIVFLTLLLCGGLGLVFAFTVDTNLAIAISLSFLALIYIFFIVIYFGGRREGESWNWAWALSTRLARHIGYLELLFKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDACEREFGFLATRLFRVFRTEESQGKKKWKKTCCLPSFVIFLFIVGCIIAGITLLAIFRVDPKHLTVNAILISIASVVGLAFVLNCRTWWQVLDSLLNSQRKRLHSAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDITCSDTTGTQEDTDRRVSQNSLGEMTKLGSKTALNRRDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQITFNWDRLASWINLTEQWPYRTSWLILYLEETEGLPDQMTLKTIYERISKNIPTTKDVEPLLEIDGDIRNFEVFLSSRTPVLVARDVKTFLPCTVNLDPKLREIIADVRAAREQINIGGLAYPPLPLHEGPPRPPSGYSQPASVCSSASFNGPFPGGVVSPQPHSSYYSGLSGPQHPFYNRPFFAPYLYTPRYYPGGSQHLISRSSVKTSLPRDQNNGLPCDSGFNKQRQAAVPATGSSLLLSSMTVDVVCEKLRQIEGLDQSMMPQYCTTIKKANINGRVLSQCNIDELKKEMAMNFGDWHLFRSMVLEMRSVESQVVPEDPRFLNENSSAPVPHGESARRSSHTELPLTELSSQTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNSQDSSIEISKLTDKVQAEYRDAYREYIAQMSQLEGGTGSSTISGRSSPHSTYYIGQSSSGGSIHSTLEQERGKEGELKQEDGRKSFLMKRGDVIDYSSSGVSTNEASPLDPITEEDEKSDQSGSKLLPGKKSSERPSLFQTDLKLKGGGLRYQKLPSDEDESGTEESDNTPLLKDDKDKKAEGKAERVCKSPEHSAEPIRTFIKAKEYLSDALLDKKDSSDSGVRSNESSPNHSLHNEAADDSQLEKANLIELEDEGHSGKRGMPHSLSGLQDPIIARMSICSEDKKSPSECSLIASSPEESWPACQKAYNLNRTPSTVTLNNNTAPTNRANQNFDEIEGIRETSQVILRPGPSPNPTAVQNENLKSMAHKRSQRSSYTRLSKDASELHAASSESTGFGEERESIL
uniprot
proteins
function
FUNCTION: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. {ECO:0000269|PubMed:11150334, ECO:0000269|PubMed:15167895, ECO:0000269|PubMed:15939763, ECO:0000269|PubMed:17724123}.
uniprot
proteins
mass_dalton
195716
uniprot
proteins
mutagenesis
MUTAGEN 918; /note="S->A: Loss of phosphorylation."; /evidence="ECO:0000269|PubMed:10998417"; MUTAGEN 1760; /note="S->D: Loss of binding to PDZ domain of SNTA1 and SNTB2."; /evidence="ECO:0000269|PubMed:15939763
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF). {ECO:0000269|PubMed:10998417, ECO:0000269|PubMed:11150334, ECO:0000269|PubMed:15167895, ECO:0000269|PubMed:15939763}.
uniprot
proteins
pubmed
10998417
uniprot
proteins
pubmed
11150334
uniprot
proteins
pubmed
15167895
uniprot
proteins
pubmed
15378608
uniprot
proteins
pubmed
15939763
uniprot
proteins
pubmed
17724123
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1762
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Late endosome {ECO:0000269|PubMed:10998417, ECO:0000269|PubMed:17724123}. Note=Localized at late endosome before or after nerve growth factor (NGF) stimulation.
uniprot
proteins
transmembrane_region
TRANSMEM 509..529; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 534..554; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 669..689; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 697..717; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins