STIM2
entrez
57620
canonical
uniprot
Q9P246
canonical
ensembl
ENSG00000109689
resolver
ensp
ENSP00000417569
resolver
ensp
ENSP00000419073
resolver
ensp
ENSP00000419383
resolver
enst
ENST00000465503
resolver
genesymbol
STIM2
resolver
genesymbol_syn
KIAA1482
resolver
hgnc
HGNC:19205
resolver
uniprot
A6H8L7
resolver
uniprot
B3KUB5
resolver
uniprot
B7ZVY0
resolver
uniprot
H0Y860
resolver
uniprot
Q96BF1
resolver
uniprot
Q9BQH2
resolver
uniprot
Q9H8R1
resolver
uniprot_entry
B3KUB5_HUMAN
resolver
uniprot_entry
H0Y860_HUMAN
resolver
uniprot_entry
STIM2_HUMAN
resolver
uniprot_sec
A6H8L7
resolver
uniprot_sec
B7ZVY0
resolver
uniprot_sec
Q96BF1
resolver
uniprot_sec
Q9BQH2
resolver
uniprot_sec
Q9H8R1
resolver
amino_acid_sequence
MLVLGLLVAGAADGCELVPRHLRGRRATGSAATAASSPAAAAGDSPALMTDPCMSLSPPCFTEEDRFSLEALQTIHKQMDDDKDGGIEVEESDEFIREDMKYKDATNKHSHLHREDKHITIEDLWKRWKTSEVHNWTLEDTLQWLIEFVELPQYEKNFRDNNVKGTTLPRIAVHEPSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRPPHNWMKDFILTVSIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYSDHSWVVMPRVSIPPYPIAGGVDDLDEDTPPIVSQFPGTMAKPPGSLARSSSLCRSRRSIVPSSPQPQRAQLAPHAPHPSHPRHPHHPQHTPHSLPSPDPDILSVSSCPALYRNEEEEEAIYFSAEKQWEVPDTASECDSLNSSIGRKQSPPLSLEIYQTLSPRKISRDEVSLEDSSRGDSPVTVDVSWGSPDCVGLTETKSMIFSPASKVYNGILEKSCSMNQLSSGIPVPKPRHTSCSSAGNDSKPVQEAPSVARISSIPHDLCHNGEKSKKPSKIKSLFKKKSK
uniprot
proteins
function
FUNCTION: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}.
uniprot
proteins
mass_dalton
83971
uniprot
proteins
mutagenesis
MUTAGEN 80; /note="D->A: No effect on inhibitory activity; when associated with A-91."; /evidence="ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:18160041"; MUTAGEN 91; /note="E->A: No effect on inhibitory activity; when associated with A-80."; /evidence="ECO:0000269|PubMed:16860747
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:11463338}.; PTM: Phosphorylated predominantly on Ser residues. {ECO:0000269|PubMed:11463338}.
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11463338
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16005298
uniprot
proteins
pubmed
16860747
uniprot
proteins
pubmed
17905723
uniprot
proteins
pubmed
18160041
uniprot
proteins
pubmed
18166150
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19019825
uniprot
proteins
pubmed
21217057
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22464749
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23359669
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
746
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041}; Single-pass type I membrane protein {ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041}. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.
uniprot
proteins
transmembrane_region
TRANSMEM 219..235; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins