Cdk2
entrez
12566
canonical
uniprot
P97377
canonical
ensembl
ENSMUSG00000025358
resolver
ensp
ENSMUSP00000026415
resolver
ensp
ENSMUSP00000026416
resolver
genesymbol
Cdk2
resolver
genesymbol_syn
Cdkn2
resolver
uniprot
O55105
resolver
uniprot
Q3U6X7
resolver
uniprot
Q3UGB9
resolver
uniprot_entry
CDK2_MOUSE
resolver
uniprot_entry
Q3U6X7_MOUSE
resolver
uniprot_entry
Q3UGB9_MOUSE
resolver
uniprot_sec
O55105
resolver
activity_regulation
ACTIVITY REGULATION: Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-160 activates it (By similarity). Phosphorylated and activated by CDK7 in the CDK-activating kinase (CAK) complex, and reciprocally phosphorylating its activating kinase CDK7 (By similarity). Stimulated by MYC. Inactivated by CDKN1A (p21). {ECO:0000250|UniProtKB:P24941}.
uniprot
proteins
amino_acid_sequence
MENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMHLVCTQHHAKCCGEHRRNGRHSLCPLCSYLEVAASQGGGMTAVSAPHPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
uniprot
proteins
ec_number
2.7.11.22
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (PubMed:11733001, PubMed:12923533, PubMed:14561402, PubMed:17942597, PubMed:23853094). Phosphorylates CABLES1, CTNNB1, CDK2AP2, ERCC6, NBN, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, SUV39H1, EZH2 (PubMed:11733001, PubMed:23853094). Triggers duplication of centrosomes and DNA (By similarity). Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus (By similarity). Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in embryonic stem cells (ESCs) (By similarity). Activated by the CDK-activating kinase (CAK) complex consisting of CDK7, cyclin-H/CCNH and MAT1, which is a master regulator of CDK activity (By similarity). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase (By similarity). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC (By similarity). Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis (By similarity). In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation (By similarity). Involved in regulation of telomere repair by mediating phosphorylation of NBN (By similarity). Phosphorylation of RB1 disturbs its interaction with E2F1 (By similarity). NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociation from unduplicated centrosomes, thus initiating centrosome duplication (By similarity). Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase (By similarity). Required for vitamin D-mediated growth inhibition by being itself inactivated (By similarity). Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner (By similarity). USP37 is activated by phosphorylation and thus triggers G1-S transition (By similarity). CTNNB1 phosphorylation regulates insulin internalization (By similarity). Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (PubMed:23853094). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (By similarity). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of the C-terminus of protein kinase B (PKB/AKT1 and PKB/AKT2), promoting its activation (PubMed:24670654). {ECO:0000250|UniProtKB:P24941, ECO:0000269|PubMed:11733001, ECO:0000269|PubMed:12923533, ECO:0000269|PubMed:14561402, ECO:0000269|PubMed:17942597, ECO:0000269|PubMed:23853094, ECO:0000269|PubMed:24670654}.
uniprot
proteins
mass_dalton
38978
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="Y->F: Loss of tyrosine phosphorylation by WEE1 and CABLES1."; /evidence="ECO:0000269|PubMed:11585773
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-160 by CDK7 in a CAK complex. Phosphorylation at Thr-160 promotes kinase activity, whereas phosphorylation at Tyr-15 by WEE1 reduces slightly kinase activity. Phosphorylated on Thr-14 and Tyr-15 during S and G2 phases before being dephosphorylated by CDC25A. {ECO:0000250|UniProtKB:P24941}.; PTM: Nitrosylated after treatment with nitric oxide (DETA-NO). {ECO:0000250|UniProtKB:P24941}.
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11585773
uniprot
proteins
pubmed
11733001
uniprot
proteins
pubmed
12923533
uniprot
proteins
pubmed
14561402
uniprot
proteins
pubmed
15107404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17942597
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23853094
uniprot
proteins
pubmed
24670654
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus, Cajal body {ECO:0000250}. Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}. Note=Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3) (By similarity). {ECO:0000250}.
uniprot
proteins