Hook3
entrez
320191
canonical
uniprot
Q8BUK6
canonical
ensembl
ENSMUSG00000037234
resolver
ensp
ENSMUSP00000046788
resolver
enst
ENSMUST00000037182
resolver
genesymbol
Hook3
resolver
uniprot
Q540A0
resolver
uniprot
Q8BV48
resolver
uniprot
Q8BW57
resolver
uniprot
Q8BY41
resolver
uniprot_entry
HOOK3_MOUSE
resolver
uniprot_sec
Q540A0
resolver
uniprot_sec
Q8BV48
resolver
uniprot_sec
Q8BW57
resolver
uniprot_sec
Q8BY41
resolver
amino_acid_sequence
MFNVESVERVELCESLLTWIQTFNVDAPCQTAEDLTNGVVMSQVLQKIDPVYFDDNWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGHDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQILMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARGQLETYKRQVVELQNRLSDESKKADKLDFEYKRLKEKVDGLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEDSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLRIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQRDMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSTRRSYPGHVQPATAR
uniprot
proteins
function
FUNCTION: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. {ECO:0000250|UniProtKB:Q86VS8}.; FUNCTION: (Microbial infection) Serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. {ECO:0000269|PubMed:12950921}.
uniprot
proteins
mass_dalton
83218
uniprot
proteins
protein_family
Hook family
uniprot
proteins
pubmed
11238449
uniprot
proteins
pubmed
12950921
uniprot
proteins
pubmed
15075236
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17140400
uniprot
proteins
pubmed
17237231
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28003339
uniprot
proteins
pubmed
28283191
uniprot
proteins
sequence_length
718
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15075236, ECO:0000269|PubMed:28003339}. Golgi apparatus {ECO:0000269|PubMed:15075236}. Note=Enriched at the cis-face of the Golgi complex (By similarity). Localizes to microtubule asters in prophase (By similarity). Localizes to the manchette in elongating spermatids (PubMed:28003339). {ECO:0000250|UniProtKB:Q86VS8, ECO:0000269|PubMed:28003339}.
uniprot
proteins