Selenos
entrez
109815
canonical
uniprot
Q9BCZ4
canonical
ensembl
ENSMUSG00000075701
resolver
ensp
ENSMUSP00000099301
resolver
genesymbol
Selenos
resolver
genesymbol_syn
H47
resolver
genesymbol_syn
Vimp
resolver
uniprot
Q921S1
resolver
uniprot
Q9DB55
resolver
uniprot_entry
SELS_MOUSE
resolver
uniprot_sec
Q921S1
resolver
uniprot_sec
Q9DB55
resolver
amino_acid_sequence
MDRDEEPLSARPALETESLRFLHVTVGSLLASYGWYILFSCILLYIVIQRLSLRLRALRQRQLDQAETVLEPDVVVKRQEALAAARLRMQEDLNAQVEKHKEKLRQLEEEKRRQKIEMWDSMQEGRSYKRNSGRPQEEDGPGPSTSSVIPKGKSDKKPLRGGGYNPLTGEGGGTCSWRPGRRGPSSGGUN
uniprot
proteins
function
FUNCTION: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
21509
uniprot
proteins
post_translational_modification
PTM: Truncated SELENOS proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC2) and CRL2(KLHDC3) complexes, which recognizes the glycine (Gly) at the C-terminus of truncated SELENOS proteins. Truncated SELENOS proteins produced by failed UGA/Sec decoding are also ubiquitinated by the CRL5(KLHDC1) complex. {ECO:0000250|UniProtKB:Q9BQE4}.
uniprot
proteins
protein_family
Selenoprotein S family
uniprot
proteins
pubmed
11254699
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25009997
uniprot
proteins
sequence_length
190
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..48; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins