Mtch2
entrez
56428
canonical
uniprot
Q791V5
canonical
ensembl
ENSMUSG00000027282
resolver
ensp
ENSMUSP00000107092
resolver
ensp
ENSMUSP00000118566
resolver
ensp
ENSMUSP00000121851
resolver
enst
ENSMUST00000111467
resolver
enst
ENSMUST00000136872
resolver
enst
ENSMUST00000150232
resolver
genesymbol
Mtch2
resolver
genesymbol_syn
Mimp
resolver
uniprot
A2AFW6
resolver
uniprot
F6VJL8
resolver
uniprot
Q3TPS5
resolver
uniprot
Q99LZ6
resolver
uniprot
Q9D050
resolver
uniprot
Q9D060
resolver
uniprot
Q9D7Y2
resolver
uniprot
Q9QZP3
resolver
uniprot_entry
A2AFW6_MOUSE
resolver
uniprot_entry
F6VJL8_MOUSE
resolver
uniprot_entry
MTCH2_MOUSE
resolver
uniprot_entry
Q9D050_MOUSE
resolver
uniprot_sec
Q3TPS5
resolver
uniprot_sec
Q99LZ6
resolver
uniprot_sec
Q9D060
resolver
uniprot_sec
Q9D7Y2
resolver
uniprot_sec
Q9QZP3
resolver
amino_acid_sequence
MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLPPTIGRNIFGRQVCQLPGLFCYAQHIASIDGRRGLFTGLTPRLCSGVLGTVVHGKVLQYYQESEKPEELGSVTVQKEYSSSFDRVIKETTREMIARSAATLITHPFHVITLRSMVQFIGRESKYCGLCDSIVTIYREEGIVGFFAGLIPRLLGDIISLWLCNSLAYLINTYALDSGVSTMNEMKSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGSPPYSPIYTSWIDCWCMLQKAGNMSRGNSLFFRKVPCGKTYCYDLRMLI
uniprot
proteins
function
FUNCTION: Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane. Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins. Does not mediate insertion of beta-barrel transmembrane proteins (By similarity). Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (PubMed:20436477, PubMed:26219591, PubMed:26876167, PubMed:30510213). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (PubMed:20436477, PubMed:26219591, PubMed:26876167). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (PubMed:30510213). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (PubMed:26876167, PubMed:28127879). {ECO:0000250|UniProtKB:Q9Y6C9, ECO:0000269|PubMed:20436477, ECO:0000269|PubMed:26219591, ECO:0000269|PubMed:26876167, ECO:0000269|PubMed:28127879, ECO:0000269|PubMed:30510213}.
uniprot
proteins
mass_dalton
33499
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
12407445
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15899861
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20436477
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26219591
uniprot
proteins
pubmed
26876167
uniprot
proteins
pubmed
28127879
uniprot
proteins
pubmed
30510213
uniprot
proteins
sequence_length
303
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:15899861, ECO:0000269|PubMed:20436477}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 78..92; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 181..199; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 281..303; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins