Il11ra1
entrez
245983
canonical
uniprot
Q99MF4
canonical
ensembl
ENSRNOG00000015068
resolver
ensembl
ENSRNOG00055017207
resolver
ensembl
ENSRNOG00060004249
resolver
ensembl
ENSRNOG00065004830
resolver
ensp
ENSRNOP00000020885
resolver
ensp
ENSRNOP00055023466
resolver
ensp
ENSRNOP00060005347
resolver
ensp
ENSRNOP00065004817
resolver
enst
ENSRNOT00000020885
resolver
enst
ENSRNOT00055029172
resolver
enst
ENSRNOT00060007086
resolver
enst
ENSRNOT00065007004
resolver
genesymbol
Il11ra1
resolver
uniprot_entry
I11RA_RAT
resolver
amino_acid_sequence
MSSSRSGLTRVLVAVATALVSSSTPCPQAWGPPGVQYGQPGRPVMLCCPGVNAGTPVSWFRDGDSRLLQGPDSGLGHRLVLAQVDSRDEGTYVCRTLDGVFGGMVTLKLGSPPARPEVSCQAVDYENFSCTWSPGRVSGLPTRYLTSYRKKTLPGAESQRESPSTGPWPCPQDPLEASRCVVHGAEFWSEYRINVTEVNPLGASTCLLDVRLQRILRPDPPQGLRVESVPGYPRRLHASWTYPASWRRQPHFLLKFRLQYRPAQHPAWSTVEPIGLEELITDAVAGLPHAVRVSARDFLDAGTWSAWSPEAWGTPSTGPLRDEVPDGSRGHEQKLEAAAQEDSPAPPSPSLQPDPRPLDHRDPLEQVAVLASLGIFSFLGLAVGALALGLWLRLRRSGKDGPQKPGFLAPMIPGDKLPGIPNLQRTPENFS
uniprot
proteins
function
FUNCTION: Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. {ECO:0000250|UniProtKB:Q14626}.; FUNCTION: [Soluble interleukin-11 receptor subunit alpha]: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling. {ECO:0000250|UniProtKB:Q14626}.
uniprot
proteins
mass_dalton
46784
uniprot
proteins
post_translational_modification
PTM: A short soluble form is also released from the membrane by proteolysis. The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing. mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3. {ECO:0000250|UniProtKB:Q14626}.
uniprot
proteins
protein_family
Type 3 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
431
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Interleukin-11 receptor subunit alpha]: Membrane {ECO:0000250|UniProtKB:Q14626}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Soluble interleukin-11 receptor subunit alpha]: Secreted {ECO:0000250|UniProtKB:Q14626}.
uniprot
proteins
transmembrane_region
TRANSMEM 372..392; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins