Fdps
entrez
83791
canonical
uniprot
P05369
canonical
ensembl
ENSRNOG00000077379
resolver
ensp
ENSRNOP00000058918
resolver
genesymbol
Fdps
resolver
uniprot
Q6GT82
resolver
uniprot_entry
FPPS_RAT
resolver
uniprot_sec
Q6GT82
resolver
activity_regulation
ACTIVITY REGULATION: Inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MNGDQKLDVHNQEKQNFIQHFSQIVKVLTEDELGHPEKGDAITRIKEVLEYNTVGGKYNRGLTVVQTFQELVEPRKQDAESLQRALTVGWCVELLQAFFLVLDDIMDSSYTRRGQICWYQKPGIGLDAINDALLLEAAIYRLLKFYCREQPYYLNLLELFLQSSYQTEIGQTLDLITAPQGQVDLGRYTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANALKILLEMGEFFQIQDDYLDLFGDPSVTGKVGTDIQDNKCSWLVVQCLLRATPQQRQILEENYGQKDPEKVARVKALYEELDLRSVFFKYEEDSYNRLKSLIEQCSAPLPPSIFLELANKIYKRRK
uniprot
proteins
ec_number
2.5.1.1
uniprot
proteins
ec_number
2.5.1.10
uniprot
proteins
function
FUNCTION: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
40830
uniprot
proteins
pathway_participation
PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.; PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
uniprot
proteins
protein_family
FPP/GGPP synthase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2325654
uniprot
proteins
pubmed
3670308
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins