PRDX3
entrez
10935
canonical
uniprot
P30048
canonical
ensembl
ENSG00000165672
resolver
ensp
ENSP00000298510
resolver
ensp
ENSP00000677429
resolver
genesymbol
PRDX3
resolver
genesymbol_syn
AOP1
resolver
hgnc
HGNC:9354
resolver
uniprot
A0A384MTR2
resolver
uniprot
B2R7Z0
resolver
uniprot
D3DRC9
resolver
uniprot
E9PH29
resolver
uniprot
P35690
resolver
uniprot
Q0D2H1
resolver
uniprot
Q13776
resolver
uniprot
Q5T5V2
resolver
uniprot
Q96HK4
resolver
uniprot_entry
A0A384MTR2_HUMAN
resolver
uniprot_entry
PRDX3_HUMAN
resolver
uniprot_sec
B2R7Z0
resolver
uniprot_sec
D3DRC9
resolver
uniprot_sec
E9PH29
resolver
uniprot_sec
P35690
resolver
uniprot_sec
Q0D2H1
resolver
uniprot_sec
Q13776
resolver
uniprot_sec
Q5T5V2
resolver
uniprot_sec
Q96HK4
resolver
amino_acid_sequence
MAAAVGRLLRASVARHVSAIPWGISATAALRPAACGRTSLTNLLCSGSSQAKLFSTSSSCHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGSGLALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPANWTPDSPTIKPSPAASKEYFQKVNQ
uniprot
proteins
disease_involvement
DISEASE: Spinocerebellar ataxia, autosomal recessive, 32 (SCAR32) [MIM:619862]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR32 is characterized by the onset of gait ataxia in the second or third decades of life. Other classic features include upper limb ataxia, oculomotor signs, dysphagia, and dysarthria. Some patients may have hyper- or hypokinetic movement abnormalities. Brain imaging shows cerebellar atrophy. Atrophy can extend to the brainstem and medullary olives. {ECO:0000269|PubMed:33889951}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Corneal dystrophy, punctiform and polychromatic pre-Descemet (PPPCD) [MIM:619871]: An autosomal dominant corneal dystrophy characterized by the presence of punctiform, multicolored opacities in the posterior stroma, immediately anterior to Descemet membrane. Affected individuals are typically asymptomatic. {ECO:0000269|PubMed:31782998, ECO:0000269|PubMed:34369396}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.11.1.24
uniprot
proteins
function
FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:17707404, PubMed:29438714, PubMed:33889951, PubMed:7733872). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477). Required for the maintenance of physical strength (By similarity). {ECO:0000250|UniProtKB:P20108, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:17707404, ECO:0000269|PubMed:29438714, ECO:0000269|PubMed:33889951, ECO:0000269|PubMed:7733872}.
uniprot
proteins
mass_dalton
27693
uniprot
proteins
mutagenesis
MUTAGEN 136; /note="S->E: Forms obligate homodimers under reducing and oxidizing conditions; does not form dodecamer rings under reducing conditions."; /evidence="ECO:0000269|PubMed:29438714"; MUTAGEN 139; /note="S->C: Forms predominantly dodecamer rings."; /evidence="ECO:0000269|PubMed:29438714"; MUTAGEN 146; /note="T->A: Impairs phosphorylation."; /evidence="ECO:0000269|PubMed:21850687
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by LRRK2; phosphorylation reduces perodixase activity. {ECO:0000269|PubMed:21850687}.; PTM: The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond. {ECO:0000269|PubMed:12059788}.; PTM: S-palmitoylated. {ECO:0000250|UniProtKB:P20108}.
uniprot
proteins
protein_family
AhpC/Prx1 subfamily
uniprot
proteins
protein_family
Peroxiredoxin family
uniprot
proteins
pubmed
12059788
uniprot
proteins
pubmed
12492477
uniprot
proteins
pubmed
1286669
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15750338
uniprot
proteins
pubmed
17707404
uniprot
proteins
pubmed
19462976
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20873783
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21850687
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27238969
uniprot
proteins
pubmed
29438714
uniprot
proteins
pubmed
31782998
uniprot
proteins
pubmed
33889951
uniprot
proteins
pubmed
34369396
uniprot
proteins
pubmed
7733872
uniprot
proteins
sequence_length
256
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:33889951}. Cytoplasm {ECO:0000305|PubMed:12492477}. Early endosome {ECO:0000269|PubMed:15750338}. Note=Localizes to early endosomes in a RPS6KC1-dependent manner. {ECO:0000269|PubMed:15750338}.
uniprot
proteins