Fanci
entrez
208836
canonical
uniprot
Q8K368
canonical
ensembl
ENSMUSG00000039187
resolver
ensp
ENSMUSP00000044931
resolver
ensp
ENSMUSP00000117992
resolver
ensp
ENSMUSP00000329783
resolver
genesymbol
Fanci
resolver
uniprot
Q8BUE9
resolver
uniprot
Q8R3G8
resolver
uniprot_entry
FANCI_MOUSE
resolver
uniprot_sec
Q8BUE9
resolver
uniprot_sec
Q8R3G8
resolver
amino_acid_sequence
MDLKILSLATDKTTDKLQEFLQTLKDDDLASLLQNQAVKGRAVGTLLRAVLKGSPCSEEDGALRRYKIYSCCIQLVESGDLQQDVASEIIGLLMLEVHHFPGPLLVDLASDFVGAVREDRLVNGKSLELLPIILTALATKKEVLACGKGDLNGEEYKRQLIDTLCSVRWPQRYMIQLTSVFKDVCLTPEEMNLVVAKVLTMFSKLNLQEIPPLVYQLLVLSSKGSRRSVLDGIIAFFRELDKQHREEQSSDELSELITAPADELYHVEGTVILHIVFAIKLDCELGRELLKHLKAGQQGDPSKCLCPFSIALLLSLTRIQRFEEQVFDLLKTSVVKSFKDLQLLQGSKFLQTLVPQRTCVSTMILEVVRNSVHSWDHVTQGLIEFGFILMDSYGPKKILDGKAVEIGTSLSKMTNQHACKLGANILLETFKIHEMIRQEILEQVLNRVVTRTSSPINHFLDLFSDIIMYAPLILQNCSKVTETFDYLTFLPLQTVQGLLKAVQPLLKISMSMRDSLILVLRKAMFASQLDARKSAVAGFLLLLKNFKVLGSLPSSQCTQSIGVTQVRVDVHSRYSAVANETFCLEIIDSLKRSLGQQADIRLMLYDGFYDVLRRNSQLASSIMQTLFSQLKQFYEPEPDLLPPLKLGACVLTQGSQIFLQEPLDHLLSCIQHCLAWYKSRVVPLQQGDEGEEEEEELYSELDDMLESITVRMIKSELEDFELDKSADFSQNTNVGIKNNICACLIMGVCEVLMEYNFSISNFSKSKFEEILSLFTCYKKFSDILSEKAGKGKAKMTSKVSDSLLSLKFVSDLLTALFRDSIQSHEESLSVLRSSGEFMHYAVNVTLQKIQQLIRTGHVSGPDGQNPDKIFQNLCDITRVLLWRYTSIPTSVEESGKKEKGKSISLLCLEGLQKTFSVVLQFYQPKVQQFLQALDVMGTEEEEAGVTVTQRASFQIRQFQRSLLNLLSSEEDDFNSKEALLLIAVLSTLSRLLEPTSPQFVQMLSWTSKICKEYSQEDASFCKSLMNLFFSLHVLYKSPVTLLRDLSQDIHGQLGDIDQDVEIEKTDHFAVVNLRTAAPTVCLLVLSQAEKVLEEVDWLIAKIKGSANQETLSDKVTPEDASSQAVPPTLLIEKAIVMQLGTLVTFFHELVQTALPSGSCVDTLLKGLSKIYSTLTAFVKYYLQVCQSSRGIPNTVEKLVKLSGSHLTPVCYSFISYVQNKSSDAPKCSEKEKAAVSTTMAKVLRETKPIPNLVFAIEQYEKFLIQLSKKSKVNLMQHMKLSTSRDFKIKGSVLDMVLREDEEDENEEGTASAHTQQDREPAKKRRKKCLS
uniprot
proteins
function
FUNCTION: Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). Participates in S phase and G2 phase checkpoint activation upon DNA damage (By similarity). {ECO:0000250|UniProtKB:B0I564, ECO:0000250|UniProtKB:Q9NVI1, ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17460694}.
uniprot
proteins
mass_dalton
149326
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated by FANCL on Lys-522 during S phase and upon genotoxic stress (By similarity). Deubiquitinated by USP1 as cells enter G2/M, or once DNA repair is completed (By similarity). Monoubiquitination requires the FANCA-FANCB-FANCC-FANCE-FANCF-FANCG-FANCM complex (By similarity). Ubiquitination is required for binding to chromatin, DNA repair, and normal cell cycle progression (By similarity). Monoubiquitination is stimulated by DNA-binding (By similarity). {ECO:0000250|UniProtKB:Q9NVI1}.; PTM: Phosphorylated in response to DNA damage by ATM and/or ATR (PubMed:17412408). Phosphorylation of FANCI promotes ubiquitination of FANCD2, which prevents DNA release from the FANCI-FANCD2 complex (By similarity). {ECO:0000250|UniProtKB:B0I564, ECO:0000269|PubMed:17412408}.
uniprot
proteins
protein_family
Fanconi anemia group I protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17412408
uniprot
proteins
pubmed
17460694
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21764741
uniprot
proteins
sequence_length
1330
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NVI1}. Cytoplasm {ECO:0000250|UniProtKB:Q9NVI1}. Note=Observed in spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites. They are frequently interlinked through BLM-associated ultra-fine DNA bridges (By similarity). {ECO:0000250|UniProtKB:Q9NVI1}.
uniprot
proteins