Camsap2
entrez
67886
canonical
uniprot
Q8C1B1
canonical
ensembl
ENSMUSG00000041570
resolver
ensp
ENSMUSP00000142166
resolver
ensp
ENSMUSP00000142299
resolver
enst
ENSMUST00000192314
resolver
genesymbol
Camsap2
resolver
genesymbol_syn
Camsap1l1
resolver
genesymbol_syn
Kiaa1078
resolver
uniprot
A0A0A6YY67
resolver
uniprot
B7ZNI4
resolver
uniprot
Q80TK8
resolver
uniprot
Q8C4J5
resolver
uniprot_entry
A0A0A6YY67_MOUSE
resolver
uniprot_entry
CAMP2_MOUSE
resolver
uniprot_sec
B7ZNI4
resolver
uniprot_sec
Q80TK8
resolver
uniprot_sec
Q8C4J5
resolver
amino_acid_sequence
MGDAADPREMRRTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAFGTENVPEELGDPFYTDQYDQEHIKPPVVNLLLSAELYCRAGSLILKSDAAKPLLGHDAVIQALAQKGLYVTDQEKLVTERDLHKKPIQMSAHLAMIDTLMMAYTVEMISIEKVIACAQQYSAFFQATDLPYDIEDAVMYWMNKVNEHLKDIMEQEQKSKEHHPAEAPGGQKARYRKEQTLLKQLPCIPLVENLLKDGTDGCALAALIHFYCPAVVRLEDICLKETMSLADSLYNLQLIQEFCQEYLNHCCHFSLEDMLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPRVVRPQGAEPAKDVPSVPVLNAAKRNIRDSSSSSDFSSRYTRPQTHSSASGGIRRSSSMSYVDGFIGTWPKEKRTSVHGVSFDISFDKEDSAQSSTPNRGIIRSVSNEGLTLNNSRASKHIRKNLSFKPVNGEEEESIEEELHVDPHGDLQSPMPLNTNELNSNESTHYKLPNGALQNRVLLDEFGNQIETPSIEEALQIIHDTERPPHTPRPDQIANGFFLHGQDLSILNSNIKLNQSSPDNLTDTKGALSPITDTTEVDTGIHVPSEDIPETMDEDSSLRDYTVSLDSDMDDASKLLQDYDLRASNPREALSPCPSTISTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGKSSGSSSQKTTPEGSELNIPHVVSWAQIPEEAGVAPGRDTTQLLASEMVHLRMRLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGEGISPLREEAAGAEDEKVYTDRAKERESQKMDGQRSKSLADIKESMETPPGRWLKSPTTPVDPERQWNLTSPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQAWVISPPQPSPQKQIRDFKPRQAGLSSAAAPFSSDSPRPTHPSPQSSTRKSASFSVKNQRTPRPNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQKEPKQKEEIKKEPSECKGTLGPCDHNPGEKEIKPVESTVSEVLSQPITETVCVTPNEDQLSQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVSVEKLDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQAAKQKKQRPKSIHRDHIESPKTPIKGPPVSSLSLASLNTGDSESVHSGKRTPRSESVEGFLSPSRCGSRNGEKDWENASTTSSVASGTEYTGPKLYKEPSAKSNKHIIQNALAHCCLAGKVNEGQKKKILEEMEKSDANNFLILFRDSGCQFRSLYTYCPETEEINKLTGIGPKSITKKMIEGLYKYNSDRKQFSHIPAKTLSASVDAITIHSHLWQTKRPVTPKKLLPTKA
uniprot
proteins
function
FUNCTION: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (By similarity). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (By similarity). In addition, it also reduces the velocity of microtubule polymerization (By similarity). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (By similarity). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (By similarity). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (By similarity). Through the microtubule cytoskeleton, regulates the autophagosome transport (By similarity). {ECO:0000250|UniProtKB:Q08AD1}.
uniprot
proteins
mass_dalton
164333
uniprot
proteins
protein_family
CAMSAP1 family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23169647
uniprot
proteins
pubmed
32482850
uniprot
proteins
sequence_length
1461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q08AD1}. Golgi apparatus {ECO:0000250|UniProtKB:Q08AD1}. Cytoplasm {ECO:0000269|PubMed:32482850}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:32482850}. Note=Associated with the minus-end of microtubules and also detected at the centrosomes. Decorates the minus-end of microtubules by decreasing the rate of tubulin incorporation and remaining bound. The length of CAMSAP2-decorated stretches on the minus-end of microtubules is dependent on MAPRE1/EB1 and MAPRE3/EB3, which promote elongation of CAMSAP2-decorated microtubule stretches. Recruited to the Golgi apparatus by AKAP9 and PDE4DIP isoform 2/MMG8/SMYLE. In neurons, localizes to the minus-end of microtubules in axon and dendrites. {ECO:0000250|UniProtKB:Q08AD1}.
uniprot
proteins