MGMT
entrez
4255
canonical
uniprot
P16455
canonical
ensembl
ENSG00000170430
resolver
ensp
ENSP00000302111
resolver
ensp
ENSP00000498729
resolver
ensp
ENSP00000567127
resolver
ensp
ENSP00000567128
resolver
ensp
ENSP00000567129
resolver
ensp
ENSP00000567130
resolver
ensp
ENSP00000567131
resolver
ensp
ENSP00000567132
resolver
ensp
ENSP00000567133
resolver
ensp
ENSP00000567134
resolver
ensp
ENSP00000567135
resolver
ensp
ENSP00000567136
resolver
ensp
ENSP00000567137
resolver
ensp
ENSP00000567138
resolver
ensp
ENSP00000567139
resolver
ensp
ENSP00000567140
resolver
ensp
ENSP00000602255
resolver
ensp
ENSP00000602256
resolver
ensp
ENSP00000602257
resolver
ensp
ENSP00000633475
resolver
ensp
ENSP00000633476
resolver
enst
ENST00000306010
resolver
enst
ENST00000651593
resolver
enst
ENST00000897068
resolver
enst
ENST00000897069
resolver
enst
ENST00000897070
resolver
enst
ENST00000897071
resolver
enst
ENST00000897072
resolver
enst
ENST00000897073
resolver
enst
ENST00000897074
resolver
enst
ENST00000897075
resolver
enst
ENST00000897076
resolver
enst
ENST00000897077
resolver
enst
ENST00000897078
resolver
enst
ENST00000897079
resolver
enst
ENST00000897080
resolver
enst
ENST00000897081
resolver
enst
ENST00000932196
resolver
enst
ENST00000932197
resolver
enst
ENST00000932198
resolver
enst
ENST00000963416
resolver
enst
ENST00000963417
resolver
genesymbol
MGMT
resolver
hgnc
HGNC:7059
resolver
uniprot
A0A499FIA3
resolver
uniprot
B4DEE8
resolver
uniprot
Q5VY78
resolver
uniprot_entry
A0A499FIA3_HUMAN
resolver
uniprot_entry
B4DEE8_HUMAN
resolver
uniprot_entry
MGMT_HUMAN
resolver
uniprot_sec
Q5VY78
resolver
amino_acid_sequence
MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLMQCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAALAGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPGLGGSSGLAGAWLKGAGATSGSPPAGRN
uniprot
proteins
ec_number
2.1.1.63
uniprot
proteins
function
FUNCTION: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
uniprot
proteins
mass_dalton
21646
uniprot
proteins
mutagenesis
MUTAGEN 114; /note="Y->A: Decreases activity towards methylated DNA over 1000-fold. Slightly reduced reactivity with O6-benzylguanine."; /evidence="ECO:0000269|PubMed:7766621"; MUTAGEN 114; /note="Y->E: Loss of DNA repair activity. Slightly reduced reactivity with O6-benzylguanine."; /evidence="ECO:0000269|PubMed:7766621"; MUTAGEN 128; /note="R->A,D: Decreases activity towards methylated DNA over 1000-fold. No effect on reactivity with O6-benzylguanine."; /evidence="ECO:0000269|PubMed:10747039, ECO:0000269|PubMed:7766621"; MUTAGEN 128; /note="R->G: Loss of DNA repair activity."; /evidence="ECO:0000269|PubMed:10747039, ECO:0000269|PubMed:7766621"; MUTAGEN 128; /note="R->K,L: Slightly reduced DNA repair activity."; /evidence="ECO:0000269|PubMed:10747039, ECO:0000269|PubMed:7766621"; MUTAGEN 138; /note="P->K: Decreased reactivity with O6-benzylguanine."; /evidence="ECO:0000269|PubMed:7954470"; MUTAGEN 140; /note="P->A: Decreased reactivity with O6-benzylguanine."; /evidence="ECO:0000269|PubMed:7954470"; MUTAGEN 145; /note="C->A: Loss of DNA repair activity."; /evidence="ECO:0000269|PubMed:10747039, ECO:0000269|PubMed:7766621"; MUTAGEN 156; /note="G->A: Decreased reactivity with O6-benzylguanine."; /evidence="ECO:0000269|PubMed:7954470"; MUTAGEN 158; /note="Y->A: Reduced DNA repair activity. Decreased reactivity with O6-benzylguanine."; /evidence="ECO:0000269|PubMed:7614699"; MUTAGEN 158; /note="Y->F: Slightly reduced DNA repair activity."; /evidence="ECO:0000269|PubMed:7614699
uniprot
proteins
protein_family
MGMT family
uniprot
proteins
pubmed
10606635
uniprot
proteins
pubmed
10747039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15964013
uniprot
proteins
pubmed
1985934
uniprot
proteins
pubmed
2188979
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2359121
uniprot
proteins
pubmed
2394694
uniprot
proteins
pubmed
2405387
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7614699
uniprot
proteins
pubmed
7766621
uniprot
proteins
pubmed
7954470
uniprot
proteins
pubmed
8202360
uniprot
proteins
sequence_length
207
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins