G0S2
entrez
50486
canonical
uniprot
P27469
canonical
ensembl
ENSG00000123689
resolver
ensp
ENSP00000355996
resolver
ensp
ENSP00000561737
resolver
ensp
ENSP00000561738
resolver
ensp
ENSP00000629443
resolver
enst
ENST00000367029
resolver
enst
ENST00000891678
resolver
enst
ENST00000891679
resolver
enst
ENST00000959384
resolver
genesymbol
G0S2
resolver
hgnc
HGNC:30229
resolver
uniprot
Q6FGC8
resolver
uniprot_entry
G0S2_HUMAN
resolver
uniprot_sec
Q6FGC8
resolver
amino_acid_sequence
METVQELIPLAKEMMAQKRKGKMVKLYVLGSVLALFGVVLGLMETVCSPFTAARRLRDQEAAVAELQAALERQALQKQALQEKGKQQDTVLGGRALSNRQHAS
uniprot
proteins
function
FUNCTION: Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. {ECO:0000269|PubMed:19706769}.
uniprot
proteins
mass_dalton
11321
uniprot
proteins
mutagenesis
MUTAGEN 35; /note="L->A: No effect on BCL2-binding; when associated with A-36."; /evidence="ECO:0000269|PubMed:19706769"; MUTAGEN 36; /note="F->A: No effect on BCL2-binding; when associated with A-35."; /evidence="ECO:0000269|PubMed:19706769"; MUTAGEN 38; /note="V->A: No effect on BCL2-binding; when associated with A-39."; /evidence="ECO:0000269|PubMed:19706769"; MUTAGEN 39; /note="V->A: No effect on BCL2-binding; when associated with A-38."; /evidence="ECO:0000269|PubMed:19706769"; MUTAGEN 43; /note="M->A: No effect on BCL2-binding; when associated with A-44."; /evidence="ECO:0000269|PubMed:19706769"; MUTAGEN 44; /note="E->A: No effect on BCL2-binding; when associated with A-43."; /evidence="ECO:0000269|PubMed:19706769"; MUTAGEN 45; /note="T->A: No effect on BCL2-binding; when associated with A-46."; /evidence="ECO:0000269|PubMed:19706769"; MUTAGEN 46; /note="V->A: No effect on BCL2-binding; when associated with A-45."; /evidence="ECO:0000269|PubMed:19706769"; MUTAGEN 50; /note="F->A: Reduced BCL2-binding; when associated with A-51."; /evidence="ECO:0000269|PubMed:19706769"; MUTAGEN 51; /note="T->A: Reduced BCL2-binding; when associated with A-50."; /evidence="ECO:0000269|PubMed:19706769"; MUTAGEN 54; /note="R->A: Reduced BCL2-binding; when associated with A-55."; /evidence="ECO:0000269|PubMed:19706769"; MUTAGEN 55; /note="R->A: Reduced BCL2-binding; when associated with A-54."; /evidence="ECO:0000269|PubMed:19706769"; MUTAGEN 57; /note="R->A: Reduced BCL2-binding and reduced pro-apoptotic activity; when associated with A-58. No effect on mitochondrial localization; when associated with A-58."; /evidence="ECO:0000269|PubMed:19706769"; MUTAGEN 58; /note="D->A: Reduced BCL2-binding and reduced pro-apoptotic activity; when associated with A-57. No effect on mitochondrial localization; when associated with A-57."; /evidence="ECO:0000269|PubMed:19706769
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1930693
uniprot
proteins
pubmed
19706769
uniprot
proteins
sequence_length
103
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:19706769}.
uniprot
proteins