C1D
entrez
10438
canonical
uniprot
Q13901
canonical
ensembl
ENSG00000197223
resolver
ensp
ENSP00000348107
resolver
ensp
ENSP00000386468
resolver
ensp
ENSP00000386779
resolver
ensp
ENSP00000541296
resolver
ensp
ENSP00000541297
resolver
ensp
ENSP00000541298
resolver
ensp
ENSP00000541299
resolver
ensp
ENSP00000541300
resolver
ensp
ENSP00000541301
resolver
ensp
ENSP00000541302
resolver
ensp
ENSP00000541303
resolver
ensp
ENSP00000541306
resolver
ensp
ENSP00000541307
resolver
ensp
ENSP00000607627
resolver
ensp
ENSP00000607628
resolver
ensp
ENSP00000607629
resolver
ensp
ENSP00000607630
resolver
ensp
ENSP00000611608
resolver
ensp
ENSP00000611609
resolver
ensp
ENSP00000611610
resolver
ensp
ENSP00000611611
resolver
enst
ENST00000355848
resolver
enst
ENST00000409302
resolver
enst
ENST00000410067
resolver
enst
ENST00000871237
resolver
enst
ENST00000871238
resolver
enst
ENST00000871239
resolver
enst
ENST00000871240
resolver
enst
ENST00000871241
resolver
enst
ENST00000871242
resolver
enst
ENST00000871243
resolver
enst
ENST00000871245
resolver
enst
ENST00000871247
resolver
enst
ENST00000871248
resolver
enst
ENST00000937568
resolver
enst
ENST00000937569
resolver
enst
ENST00000937570
resolver
enst
ENST00000937571
resolver
enst
ENST00000941549
resolver
enst
ENST00000941550
resolver
enst
ENST00000941551
resolver
enst
ENST00000941552
resolver
genesymbol
C1D
resolver
hgnc
HGNC:29911
resolver
uniprot
A8K336
resolver
uniprot
D6W5F8
resolver
uniprot
Q05D64
resolver
uniprot_entry
C1D_HUMAN
resolver
uniprot_sec
A8K336
resolver
uniprot_sec
D6W5F8
resolver
uniprot_sec
Q05D64
resolver
amino_acid_sequence
MAGEEINEDYPVEIHEYLSAFENSIGAVDEMLKTMMSVSRNELLQKLDPLEQAKVDLVSAYTLNSMFWVYLATQGVNPKEHPVKQELERIRVYMNRVKEITDKKKAGKLDRGAASRFVKNALWEPKSKNASKVANKGKSKS
uniprot
proteins
function
FUNCTION: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). {ECO:0000250|UniProtKB:O35473, ECO:0000269|PubMed:10362552, ECO:0000269|PubMed:11801738, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:9679063}.
uniprot
proteins
mass_dalton
16019
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKDC. {ECO:0000269|PubMed:9679063}.
uniprot
proteins
protein_family
C1D family
uniprot
proteins
pubmed
10362552
uniprot
proteins
pubmed
11801738
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17412707
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
30047866
uniprot
proteins
pubmed
9469821
uniprot
proteins
pubmed
9679063
uniprot
proteins
pubmed
9852280
uniprot
proteins
sequence_length
141
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11801738}. Cytoplasm {ECO:0000269|PubMed:11801738}. Nucleus, nucleolus {ECO:0000269|PubMed:17412707}. Note=EXOSC10 is required for nucleolar localization (PubMed:17412707). Colocalizes with TSNAX in the nucleus (PubMed:11801738). {ECO:0000269|PubMed:11801738, ECO:0000269|PubMed:17412707}.
uniprot
proteins