Q499M7
uniprot
Q499M7
canonical
amino_acid_sequence
MSNRLQTVFLKTAEEKSGSHCISGCMYQVVPTIGTDGKKLLQLLPIPKSSGNLIPVVQSPVMSHGLKGNTEKPVQVTFQTQISSSSTSASVQLPVLQPANTTKYFLTGTIDTSGKDRVTSMGTGNFTPPISNTQNHGVKIHRLTRQTFTIPPSTQNDSSYFIVNTPSLPANVNSSTLPSGPPLTIPAHAEVKPVLASPLPPLVQQKILGTVTTSTSGTVEASQIPAVFYVSPVNSVKIIVDKKTQNIYHKPVTFSTSQIPPNVATKTQLNSGQHPQAAPVNLIFQEYLQPGIPCLVPVKSSNNVPSKVFNTFVDRKTLGDNTVGTPLLSTNSSSRTQSISVPIKDDGLIMFNGKVLLNKKGTYGLPSKIDQQNSVSSDIPLKDSSQVVSSSLVTEISREVLSSVLVKSKSFQLKTKSLSNSQPAPMAHIKPEKSEKVERPSFSVTSPHTTNQSTHCLKQSKIVFINPVFSDGFRTGQNTPRKENLIQNIRSSVDAATVTSQQCVFRDQEPQTQYEMASILKKDIQERSNKKYSQGNHTKASYLKNDAEFKKIFGLTKDLRVCLTRIPDHLSSTKSFDSFNNLKSSSYKDANVVMKEEKKQSFSKKRNAKPMKKMDYTKRRKIENASDMVMNVMNGTDVANSQLLSSILPISDIAQHNIITSHSTTREDKRTETEHCCHEKQEKGTLSSSTSFEQSNYFNKNYTEDIFPVTPPELEETIRDEKIRRLKQILREKEAALEELRKKMHQKQ
uniprot
proteins
function
FUNCTION: Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin. Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases. {ECO:0000250|UniProtKB:Q5T3J3}.
uniprot
proteins
mass_dalton
82669
uniprot
proteins
protein_family
LRIF1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
748
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q5T3J3}. Nucleus matrix {ECO:0000250|UniProtKB:Q5T3J3}. Note=Localizes to Barr body; recruited by SMCHD1. {ECO:0000250|UniProtKB:Q5T3J3}.
uniprot
proteins