Inhbb
entrez
25196
canonical
uniprot
P17491
canonical
ensembl
ENSRNOG00000060237
resolver
ensembl
ENSRNOG00055013134
resolver
ensembl
ENSRNOG00060005462
resolver
ensembl
ENSRNOG00065014426
resolver
ensp
ENSRNOP00000071390
resolver
ensp
ENSRNOP00055018263
resolver
ensp
ENSRNOP00060006833
resolver
ensp
ENSRNOP00065018536
resolver
enst
ENSRNOT00000086350
resolver
enst
ENSRNOT00055022495
resolver
enst
ENSRNOT00060009063
resolver
enst
ENSRNOT00065023817
resolver
genesymbol
Inhbb
resolver
uniprot
Q8K471
resolver
uniprot_entry
INHBB_RAT
resolver
uniprot_sec
Q8K471
resolver
amino_acid_sequence
MDGLPGRALGAACLLLLAAGWLGPEAWGSPTPPPSPAAPPPPPPPGAPGGSQDTCTSCGGGGGGFRRPEELGRVDGDFLEAVKRHILSRLQLRGRPNITHAVPKAAMVTALRKLHAGKVREDGRVEIPHLDGHASPGADGQERVSEIISFAETDGLASSRVRLYFFVSNEGNQNLFVVQASLWLYLKLLPYVLEKGSRRKVRVKVYFQEQGHGDRWNVVEKKVDLKRSGWHTFPITEAIQALFERGERRLNLDVQCDSCQELAVVPVFVDPGEESHRPFVVVQARLGDSRHRIRKRGLECDGRTSLCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNPGPVNSCCIPTKLSSMSMLYFDDEYNIVKRDVPNMIVEECGCA
uniprot
proteins
function
FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. {ECO:0000250|UniProtKB:P09529}.; FUNCTION: Activin B is a dimer of alpha and beta-B that plays a role in several essential biological processes including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and wound healing. Signals through type I receptor ACVR1C, abundantly expressed in pancreatic beta cells, and type II receptors like ACVR2A. Upon ligand binding, these receptors phosphorylate intracellular signaling mediators SMAD2 and SMAD3, which form a complex with SMAD4, translocate to the nucleus, and regulate gene expression. Plays a crucial role in the induction of hepcidin by inflammation through activation of ACVR1C and subsequent phosphorylation of SMAD1/5/8 (By similarity). Regulates adipocyte lipid metabolism by decreasing non-esterified fatty acids and glycerol release and increases intracellular triglyceride content (By similarity). Stimulates wound healing by promoting cell migration and hair follicle regeneration through the JNK and ERK signaling pathways downstream of RHOA (By similarity). {ECO:0000250|UniProtKB:P09529}.; FUNCTION: Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A (By similarity). Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L (By similarity). {ECO:0000250|UniProtKB:P05111, ECO:0000250|UniProtKB:P17490}.
uniprot
proteins
mass_dalton
45183
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
12729472
uniprot
proteins
pubmed
2484214
uniprot
proteins
pubmed
2628729
uniprot
proteins
pubmed
8033818
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins