Slc39a10
entrez
227059
canonical
uniprot
Q6P5F6
canonical
ensembl
ENSMUSG00000025986
resolver
ensp
ENSMUSP00000027131
resolver
ensp
ENSMUSP00000283827
resolver
ensp
ENSMUSP00000283828
resolver
ensp
ENSMUSP00000283839
resolver
enst
ENSMUST00000027131
resolver
genesymbol
Slc39a10
resolver
genesymbol_syn
Kiaa1265
resolver
genesymbol_syn
Zip10
resolver
uniprot
Q80TG2
resolver
uniprot
Q8BX42
resolver
uniprot
Q8C0L2
resolver
uniprot_entry
S39AA_MOUSE
resolver
uniprot_sec
Q80TG2
resolver
uniprot_sec
Q8BX42
resolver
uniprot_sec
Q8C0L2
resolver
amino_acid_sequence
MKVHIHTKFCLICLLTFIFHHCNHCHEDHDHGPEELHRHHRGMTESESSKFSVQDAENEKKYYIEKLFDRYGENGRLSFFGLEKLLTNLGLGEIKVVEINHEDLGHDHVSHLDILAVQEGKHFHSHTHQHFHNHLNAENHTTTSVTSKRNHKCDPEKEAAELPIKADDKHLHDRNHRFHHRHRLHHHLDHNTTRHVHNDSVAHSEHGEPGHSPSPETNKTQEQSEVKSVKVRRKEKGKRKKENSEVNTPGFLPNHDHSEQYEHNRVHKLDRVHSPGHPHAHLPEHSGHELGHGHQELDPDNEGELRHTRKREAPHVRKSAIYSTPSHKDQSEDDRQHECLNVTQLLKHFGLGPNSPISPDLFTYLCPALLYQIDSRLCIEHFDKLLVEDLNKDKTLVPEDKTNIGASAWICGIISITVISLLSLLGVILVPIINQGCFKFLLTFLVALAVGTMSGDALLHLLPHSQGGHDHSHQHTHGHGHSHGHESKEFLEEYDAVLKGLVALGGIYLLFIIEHCIRMFKHYKQQRGKQKWFMKQSTEESTIGRKLSDHKLNSTPDADWLQLKPLAGTDDSVVSEDRLNETELTDLEAQQESPPKNYLGVEEEKIMDHSHSDGLHTIHEHEVHVTSHNHHDEDKAVLRKHSHQWHHRHAHHSHGPCHSGSDLKETGIANIAWMVIMGDGIHNFSDGLAIGAAFSAGLTGGISTSIAVFCHELPHELGDFAVLLKAGMTVKQAIVYNLLSAMMAYIGMLIGTAVGQYANNITLWIFAITAGMFLYVALVDMLPEMLHGDGDHEEHGFCPVGQFILQNLGLLFGFAIMLVIALYEDKIVFDIQF
uniprot
proteins
function
FUNCTION: Zinc-influx transporter. When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT). mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT). SLC39A10-SLC39A6 heterodimers play also an essential role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (By similarity). Plays an important for both mature B-cell maintenance and humoral immune responses (PubMed:25074919). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (PubMed:28098160). {ECO:0000250|UniProtKB:Q9ULF5, ECO:0000269|PubMed:25074919, ECO:0000269|PubMed:28098160}.
uniprot
proteins
mass_dalton
94394
uniprot
proteins
post_translational_modification
PTM: Undergoes N-terminal ectodomain shedding. {ECO:0000250|UniProtKB:Q9ULF5}.
uniprot
proteins
protein_family
ZIP transporter (TC 2.A.5) family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21738690
uniprot
proteins
pubmed
25074919
uniprot
proteins
pubmed
27274087
uniprot
proteins
pubmed
28098160
uniprot
proteins
pubmed
30520657
uniprot
proteins
sequence_length
833
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21738690, ECO:0000269|PubMed:25074919}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:30520657}; Multi-pass membrane protein {ECO:0000255}. Note=Expressed at the apical membranes of proximal tubules in the kidney. {ECO:0000269|PubMed:30520657}.
uniprot
proteins
transmembrane_region
TRANSMEM 413..433; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 440..460; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 497..517; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 689..709; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 734..754; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 761..781; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 803..823; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins