GRID1
entrez
2894
canonical
uniprot
Q9ULK0
canonical
ensembl
ENSG00000182771
resolver
ensp
ENSP00000330148
resolver
genesymbol
GRID1
resolver
genesymbol_syn
KIAA1220
resolver
hgnc
HGNC:4575
resolver
uniprot
A8KAN9
resolver
uniprot
B3KXD5
resolver
uniprot
B7Z7L0
resolver
uniprot
Q8IXT3
resolver
uniprot_entry
A8KAN9_HUMAN
resolver
uniprot_entry
GRID1_HUMAN
resolver
uniprot_sec
B3KXD5
resolver
uniprot_sec
B7Z7L0
resolver
uniprot_sec
Q8IXT3
resolver
amino_acid_sequence
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISPASIELSALEMGGLAPTQTLEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPLPLSSSATMPSMQCKHRSPNGGLFRQSPVKTPIPMSFQPVPGGVLPEALDTSHGTSI
uniprot
proteins
function
FUNCTION: Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand (PubMed:38060673). Instead, forms trans-synaptic adhesion complexes with presynaptic neurexins and cerebellins, regulating NMDA and AMPA receptor activity and influencing synaptic plasticity through signal transduction (By similarity). In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine (By similarity). However, recent research disputes this ligand-gated cation channel activity (PubMed:39052831). Cation-selective ion channel can be triggered by GRM1 in dopaminergic neurons (By similarity). Also acts as a receptor for GABA, modulating inhibitory synaptic plasticity through non-ionotropic mechanisms (PubMed:38060673). {ECO:0000250|UniProtKB:O43424, ECO:0000250|UniProtKB:Q61627, ECO:0000269|PubMed:38060673, ECO:0000269|PubMed:39052831}.
uniprot
proteins
mass_dalton
112131
uniprot
proteins
mutagenesis
MUTAGEN 446; /note="E->Q: Loss of GABA recognition. No effect on serine recognition."; /evidence="ECO:0000269|PubMed:38060673"; MUTAGEN 645..654; /note="CSSYTANLAA->ISSYTANLAT: Constitutively open the extracellular-ligand-gated ion channel. Potentiated by GABA."; /evidence="ECO:0000269|PubMed:38060673
uniprot
proteins
protein_family
GRID1 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
38060673
uniprot
proteins
pubmed
39052831
uniprot
proteins
sequence_length
1009
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:38060673}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 563..583; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 638..658; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 831..851; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins