GAST
entrez
2520
canonical
uniprot
P01350
canonical
ensembl
ENSG00000184502
resolver
ensp
ENSP00000331358
resolver
enst
ENST00000329402
resolver
genesymbol
GAST
resolver
genesymbol_syn
GAS
resolver
hgnc
HGNC:4164
resolver
uniprot
P78463
resolver
uniprot
P78464
resolver
uniprot_entry
GAST_HUMAN
resolver
uniprot_sec
P78463
resolver
uniprot_sec
P78464
resolver
amino_acid_sequence
MQRLCVYVLIFALALAAFSEASWKPRSQQPDAPLGTGANRDLELPWLEQQGPASHHRRQLGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDFGRRSAEDEN
uniprot
proteins
function
FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
uniprot
proteins
mass_dalton
11394
uniprot
proteins
mutagenesis
MUTAGEN 86; /note="A->D: Small increase in ratio of gastrin-17 versus gastrin-34 production. No change in ratio of gastrin-17 versus gastrin-34 production; when associated with F-87."; /evidence="ECO:0000269|PubMed:7621822"; MUTAGEN 87; /note="Y->F: Small decrease in ratio of gastrin-17 versus gastrin-34 production. No change in ratio of gastrin-17 versus gastrin-34 production; when associated with D-86."; /evidence="ECO:0000269|PubMed:7621822
uniprot
proteins
post_translational_modification
PTM: Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.; PTM: Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific. {ECO:0000269|PubMed:11052986, ECO:0000269|PubMed:7530658, ECO:0000269|PubMed:7621822}.
uniprot
proteins
protein_family
Gastrin/cholecystokinin family
uniprot
proteins
pubmed
11052986
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2730647
uniprot
proteins
pubmed
3034736
uniprot
proteins
pubmed
3223964
uniprot
proteins
pubmed
5822140
uniprot
proteins
pubmed
5921183
uniprot
proteins
pubmed
6087340
uniprot
proteins
pubmed
6322186
uniprot
proteins
pubmed
6324077
uniprot
proteins
pubmed
6574456
uniprot
proteins
pubmed
6689486
uniprot
proteins
pubmed
7530658
uniprot
proteins
pubmed
7621822
uniprot
proteins
pubmed
8055952
uniprot
proteins
sequence_length
101
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins