Klhl40
entrez
72330
canonical
uniprot
Q9D783
canonical
ensembl
ENSMUSG00000074001
resolver
ensp
ENSMUSP00000095873
resolver
enst
ENSMUST00000098272
resolver
genesymbol
Klhl40
resolver
genesymbol_syn
Kbtbd5
resolver
uniprot
A0A0R4J166
resolver
uniprot
B9EHG6
resolver
uniprot
Q059P8
resolver
uniprot
Q3TUF0
resolver
uniprot_entry
A0A0R4J166_MOUSE
resolver
uniprot_entry
KLH40_MOUSE
resolver
uniprot_sec
B9EHG6
resolver
uniprot_sec
Q059P8
resolver
uniprot_sec
Q3TUF0
resolver
amino_acid_sequence
MTLGLEQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRVGEREFPCHRLVLAACSPYFRARFLAEPDSAGEVRLEEVSPDVVSQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLANCLAVFRLGLLLDCARLAVAARDFICARFPLVARDNDFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWASSGDAEAQAERQRALPTVFESVRCRLLPRAFLETRVERHPLVRSQPELLRKVQMVKDAHEGRLTTLRKKKKEKGEQTARAKEANQGTEDTKAEDDEERVLPGILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLSTQIPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNAIYVVGGRELKDSEDSLDSVLCYDRLSFKWGESDPLPYAVYGHTVLSHMDLVYVIGGKGKDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIFVAAGVTDTGLTSSSEVYSIADNKWTSFEAFPQERSSLSLVSLAGTLYALGGFATLETESGELVPTELNDIWRYNEDEKKWEGVLREIAYAAGATFLPVRLNVVRLTKM
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:25940086). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (PubMed:25940086). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (PubMed:24960163). {ECO:0000269|PubMed:24960163, ECO:0000269|PubMed:25940086}.
uniprot
proteins
mass_dalton
69589
uniprot
proteins
protein_family
KLHL40 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23746549
uniprot
proteins
pubmed
24361185
uniprot
proteins
pubmed
24960163
uniprot
proteins
pubmed
25940086
uniprot
proteins
sequence_length
621
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25940086}. Cytoplasm, myofibril, sarcomere, A band {ECO:0000269|PubMed:24960163}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000269|PubMed:24960163}.
uniprot
proteins