Sh3rf2
entrez
307472
canonical
uniprot
Q498M5
canonical
ensembl
ENSRNOG00000018780
resolver
ensembl
ENSRNOG00055018442
resolver
ensembl
ENSRNOG00060011875
resolver
ensembl
ENSRNOG00065019387
resolver
ensp
ENSRNOP00000025409
resolver
ensp
ENSRNOP00055025301
resolver
ensp
ENSRNOP00060015759
resolver
ensp
ENSRNOP00065026065
resolver
enst
ENSRNOT00000025408
resolver
enst
ENSRNOT00055031344
resolver
enst
ENSRNOT00060020086
resolver
enst
ENSRNOT00065032640
resolver
genesymbol
Sh3rf2
resolver
genesymbol_syn
Posh3
resolver
genesymbol_syn
Posher
resolver
genesymbol_syn
Ppp1r39
resolver
genesymbol_syn
Rnf158
resolver
uniprot_entry
SH3R2_RAT
resolver
amino_acid_sequence
MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRIFKAHKELRCPECRTLVFCSIEALPANLLLVRLLDGVRSGHNSWRGGSFRRPRILTLQDNRKAKSSPRSLQASPFRLGPTVRIHMDGVPRAKALCNYRGKNPGDLKFNKGDVILLQRQLDENWYQGEINGVSGFFPASSVEVIKQLPQPPPLCRALYNFDLRDKDKSENQDCLTFLKDDVITVISRVDENWAEGKLGDKVGIFPILFVEPNLSARHLLEKSKGHQLSRTKHLSLMSSPSRGKATNTSTLRKSPGSRRKGSGQFAMTTALNTLNRMVHSPEGHQMVEISTPVLISSTSPSMLTQHGDRADFPASSAGQVSTSHPAPASPGHSTAMVSVPSSQQHLSTNMFVALHTYSAQGPEELDLKKGEGIRVLGKNQDGWLRGVSLVTGRTGIFPSDYVIPVFSSTARKTSSFPDSRHPTVCTTWALSTSSVSSQGSFSEGDPRQSGPFRSVFVPTAVNPPRSTSGPGTSGQGSLRKVRSSMRKNGSLQRPVQSGIPTFMVGSLRCSPAMVIRPQKFQFYQPQGMTPSPTPIMVEIGSKSISTGEPALTCINRGGKTRTHSAGNSIIMEGKETPIKSEPPPKPPASAPPSILVKPENSKNGIEKQVKTVRFQNYSPPPTKHSASGPTSGKHEQPATLKGSQPEAVSSEGEMTILFAHRSGCHSGQQTDLRRKSAFSKTTPPVSTASVSQTLFPSK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Has E3 ubiquitin-protein ligase activity. Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity (By similarity). {ECO:0000250|UniProtKB:Q8TEC5, ECO:0000269|PubMed:22128169}.
uniprot
proteins
mass_dalton
79880
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000250|UniProtKB:Q8TEC5}.
uniprot
proteins
protein_family
SH3RF family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22128169
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
735
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TEC5}.
uniprot
proteins