Rprd1b
entrez
70470
canonical
uniprot
Q9CSU0
canonical
ensembl
ENSMUSG00000027651
resolver
ensp
ENSMUSP00000029180
resolver
ensp
ENSMUSP00000099412
resolver
ensp
ENSMUSP00000105144
resolver
ensp
ENSMUSP00000246541
resolver
ensp
ENSMUSP00000246550
resolver
enst
ENSMUST00000103123
resolver
genesymbol
Rprd1b
resolver
genesymbol_syn
Crept
resolver
uniprot
A0A0R4J195
resolver
uniprot
A2ACF2
resolver
uniprot
A2ACF4
resolver
uniprot
A2ACF5
resolver
uniprot
A2ACF6
resolver
uniprot
Q1WDE6
resolver
uniprot
Q3U8H1
resolver
uniprot
Q3UGH1
resolver
uniprot
Q3USX3
resolver
uniprot
Q6GTJ6
resolver
uniprot_entry
A0A0R4J195_MOUSE
resolver
uniprot_entry
RPR1B_MOUSE
resolver
uniprot_sec
A2ACF2
resolver
uniprot_sec
A2ACF4
resolver
uniprot_sec
A2ACF5
resolver
uniprot_sec
A2ACF6
resolver
uniprot_sec
Q1WDE6
resolver
uniprot_sec
Q3U8H1
resolver
uniprot_sec
Q3UGH1
resolver
uniprot_sec
Q3USX3
resolver
uniprot_sec
Q6GTJ6
resolver
amino_acid_sequence
MSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKAAEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKEVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSLPDLSLLPNVTGGLAPLPSAGDLFSTD
uniprot
proteins
function
FUNCTION: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000250|UniProtKB:Q9NQG5}.
uniprot
proteins
mass_dalton
36884
uniprot
proteins
protein_family
UPF0400 (RTT103) family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22264791
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NQG5}.
uniprot
proteins