SELENOF
entrez
9403
canonical
uniprot
O60613
canonical
ensembl
ENSG00000183291
resolver
ensp
ENSP00000328729
resolver
ensp
ENSP00000359585
resolver
enst
ENST00000331835
resolver
enst
ENST00000370554
resolver
genesymbol
SELENOF
resolver
genesymbol_syn
SEP15
resolver
hgnc
HGNC:17705
resolver
uniprot
A0A0B4J1S4
resolver
uniprot
Q4GZG7
resolver
uniprot
Q8WU00
resolver
uniprot
Q9BS64
resolver
uniprot
Q9GZW0
resolver
uniprot
Q9NR01
resolver
uniprot_entry
SEP15_HUMAN
resolver
uniprot_sec
A0A0B4J1S4
resolver
uniprot_sec
Q4GZG7
resolver
uniprot_sec
Q8WU00
resolver
uniprot_sec
Q9BS64
resolver
uniprot_sec
Q9GZW0
resolver
uniprot_sec
Q9NR01
resolver
amino_acid_sequence
MVAMAAGPSGCLVPAFGLRLLLATVLQAVSAFGAEFSSEACRELGFSSNLLCSSCDLLGQFNLLQLDPDCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLERI
uniprot
proteins
function
FUNCTION: May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic reticulum (PubMed:24415556). May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (PubMed:24415556). {ECO:0000250|UniProtKB:Q923V8, ECO:0000269|PubMed:24415556}.
uniprot
proteins
mass_dalton
18092
uniprot
proteins
mutagenesis
MUTAGEN 96; /note="U->C: Does not affect protein folding and binding to UGGT1 or UGGT2."; /evidence="ECO:0000269|PubMed:24415556
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.
uniprot
proteins
protein_family
Selenoprotein M/F family
uniprot
proteins
pubmed
10945981
uniprot
proteins
pubmed
11278576
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24415556
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27645994
uniprot
proteins
pubmed
29410696
uniprot
proteins
pubmed
9535873
uniprot
proteins
sequence_length
165
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:11278576}. Note=The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum.
uniprot
proteins