P3H3
entrez
10536
canonical
uniprot
Q8IVL6
canonical
ensembl
ENSG00000110811
resolver
ensp
ENSP00000478600
resolver
genesymbol
P3H3
resolver
genesymbol_syn
LEPREL2
resolver
hgnc
HGNC:19318
resolver
uniprot
Q13512
resolver
uniprot
Q15740
resolver
uniprot
Q66K32
resolver
uniprot
Q6NX61
resolver
uniprot
Q7L2T1
resolver
uniprot_entry
P3H3_HUMAN
resolver
uniprot_sec
Q13512
resolver
uniprot_sec
Q15740
resolver
uniprot_sec
Q66K32
resolver
uniprot_sec
Q6NX61
resolver
uniprot_sec
Q7L2T1
resolver
amino_acid_sequence
MLRLLRPLLLLLLLPPPGSPEPPGLTQLSPGAPPQAPDLLYADGLRAYAAGAWAPAVALLREALRSQAALGRVRLDCGASCAADPGAALPAVLLGAPEPDSGPGPTQGSWERQLLRAALRRADCLTQCAARRLGPGGAARLRVGSALRDAFRRREPYNYLQRAYYQLKKLDLAAAAAHTFFVANPMHLQMREDMAKYRRMSGVRPQSFRDLETPPHWAAYDTGLELLGRQEAGLALPRLEEALQGSLAQMESCRADCEGPEEQQGAEEEEDGAASQGGLYEAIAGHWIQVLQCRQRCVGETATRPGRSFPVPDFLPNQLRRLHEAHAQVGNLSQAIENVLSVLLFYPEDEAAKRALNQYQAQLGEPRPGLGPREDIQRFILRSLGEKRQLYYAMEHLGTSFKDPDPWTPAALIPEALREKLREDQEKRPWDHEPVKPKPLTYWKDVLLLEGVTLTQDSRQLNGSERAVLDGLLTPAECGVLLQLAKDAAGAGARSGYRGRRSPHTPHERFEGLTVLKAAQLARAGTVGSQGAKLLLEVSERVRTLTQAYFSPERPLHLSFTHLVCRSAIEGEQEQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFQGGDLFFTEPNALTVTARVRPRCGRLVAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWIEAKELLQESQEEEEEEEEEMPSKDPSPEPPSRRHQRVQDKTGRAPRVREEL
uniprot
proteins
ec_number
1.14.11.7
uniprot
proteins
function
FUNCTION: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, either because a proline substrate for P3H3 remains to be identified or either is lost enzyme activity over the course of evolution. Also requires for lysyl hydroxylation of type V collagen in the skin, either by supporting hydroxylation of type V collagen by PLOD2/LH2 or by having itself a lysyl hydroxylase activity. {ECO:0000250|UniProtKB:Q8CG70}.
uniprot
proteins
mass_dalton
81837
uniprot
proteins
protein_family
Leprecan family
uniprot
proteins
pubmed
15063763
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
28115524
uniprot
proteins
pubmed
8723724
uniprot
proteins
pubmed
9074930
uniprot
proteins
sequence_length
736
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138}.
uniprot
proteins