Aqp3
entrez
11828
canonical
uniprot
Q8R2N1
canonical
ensembl
ENSMUSG00000028435
resolver
ensp
ENSMUSP00000055110
resolver
enst
ENSMUST00000055327
resolver
genesymbol
Aqp3
resolver
uniprot
Q3TU75
resolver
uniprot
Q9JJN8
resolver
uniprot
Q9WTJ3
resolver
uniprot_entry
AQP3_MOUSE
resolver
uniprot_sec
Q3TU75
resolver
uniprot_sec
Q9JJN8
resolver
uniprot_sec
Q9WTJ3
resolver
amino_acid_sequence
MGRQKELMNRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILVAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYALAQTLGAFLGAGIVFGLYYDAIWAFANNELFVSGPNGTAGIFATYPSGHLDMVNGFFDQFIGTAALIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSEVFTTGRHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSTEEENVKLAHMKHKEQI
uniprot
proteins
function
FUNCTION: Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:11880378, PubMed:12771381, PubMed:17429015, PubMed:19468303). Could also be permeable to urea (By similarity). Also participates in cell permeability to H2O2 and H2O2-mediated signaling (By similarity). In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair (PubMed:11880378, PubMed:12771381). In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance (PubMed:10737773). {ECO:0000250|UniProtKB:P47862, ECO:0000250|UniProtKB:Q92482, ECO:0000269|PubMed:10737773, ECO:0000269|PubMed:11880378, ECO:0000269|PubMed:12771381, ECO:0000269|PubMed:17429015, ECO:0000269|PubMed:19468303}.
uniprot
proteins
mass_dalton
31568
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
10737773
uniprot
proteins
pubmed
10777495
uniprot
proteins
pubmed
11880378
uniprot
proteins
pubmed
12771381
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16641094
uniprot
proteins
pubmed
17429015
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q92482}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14520}. Basolateral cell membrane {ECO:0000269|PubMed:16641094}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14520}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..42; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 57..74; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 101..121; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 160..177; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 190..206; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 243..264; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O14520
uniprot
proteins