BEND3
entrez
57673
canonical
uniprot
Q5T5X7
canonical
ensembl
ENSG00000178409
resolver
ensp
ENSP00000358038
resolver
ensp
ENSP00000411268
resolver
ensp
ENSP00000575524
resolver
ensp
ENSP00000598417
resolver
ensp
ENSP00000598418
resolver
ensp
ENSP00000598419
resolver
ensp
ENSP00000598420
resolver
ensp
ENSP00000598421
resolver
ensp
ENSP00000598422
resolver
ensp
ENSP00000598423
resolver
ensp
ENSP00000598424
resolver
ensp
ENSP00000598425
resolver
ensp
ENSP00000598426
resolver
ensp
ENSP00000598427
resolver
ensp
ENSP00000598428
resolver
ensp
ENSP00000613462
resolver
enst
ENST00000369042
resolver
enst
ENST00000429433
resolver
enst
ENST00000905465
resolver
enst
ENST00000928358
resolver
enst
ENST00000928359
resolver
enst
ENST00000928360
resolver
enst
ENST00000928361
resolver
enst
ENST00000928362
resolver
enst
ENST00000928363
resolver
enst
ENST00000928364
resolver
enst
ENST00000928365
resolver
enst
ENST00000928366
resolver
enst
ENST00000928367
resolver
enst
ENST00000928368
resolver
enst
ENST00000928369
resolver
enst
ENST00000943403
resolver
genesymbol
BEND3
resolver
genesymbol_syn
KIAA1553
resolver
hgnc
HGNC:23040
resolver
uniprot
A2RRH2
resolver
uniprot
Q9HCL9
resolver
uniprot_entry
BEND3_HUMAN
resolver
uniprot_sec
A2RRH2
resolver
uniprot_sec
Q9HCL9
resolver
amino_acid_sequence
MNSTEFTEDVEEVLKSITVKVETEAEDAALDCSVNSRTSEKHSVDSVLTALQDSSKRKQLVSDGLLDSVPGVKRRRLIPEALLAGMRNRENSSPCQGNGEQAGRGRSLGNVWPGEEEPCNDATTPSYKKPLYGISHKIMEKKNPPSGDLLNVYELFEKANASNSPSSLRLLNEPQKRDCGSTGAGTDNDPNIYFLIQKMFYMLNTLTSNMSQLHSKVDLLSLEVSRIKKQVSPTEMVAKFQPPPEYQLTAAELKQIVDQSLSGGDLACRLLVQLFPELFSDVDFSRGCSACGFAAKRKLESLHLQLIRNYVEVYYPSVKDTAVWQAECLPQLNDFFSRFWAQREMEDSQPSGQVASFFEAEQVDPGHFLDNKDQEEALSLDRSSTIASDHVVDTQDLTEFLDEASSPGEFAVFLLHRLFPELFDHRKLGEQYSCYGDGGKQELDPQRLQIIRNYTEIYFPDMQEEEAWLQQCAQRINDELEGLGLDAGSEGDPPRDDCYDSSSLPDDISVVKVEDSFEGERPGRRSKKIWLVPIDFDKLEIPQPDFEVPGADCLLSKEQLRSIYESSLSIGNFASRLLVHLFPELFTHENLRKQYNCSGSLGKKQLDPSRIKLIRHYVQLLYPRAKNDRVWTLEFVGKLDERCRRRDTEQRRSYQQQRKVHVPGPECRDLTSYAINPERFREEFEGPPLPPERSSKDFCKIPLDELVVPSPDFPVPSPYLLSDKEVREIVQQSLSVGNFAARLLVRLFPELFTAENLRLQYNHSGACNKKQLDPTRLRLIRHYVEAVYPVEKMEEVWHYECIPSIDERCRRPNRKKCDILKKAKKVEK
uniprot
proteins
function
FUNCTION: Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}.
uniprot
proteins
mass_dalton
94475
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="K->R: Partial loss of sumoylation. Almost complete loss of sumoylation, partial loss of transcription repression, no effect on subcellular location, loss of rDNA silencing; when associated with R-512."; /evidence="ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909"; MUTAGEN 56; /note="K->A: Loss of nuclear localization."; /evidence="ECO:0000269|PubMed:25600804"; MUTAGEN 57; /note="R->A: Loss of nuclear localization."; /evidence="ECO:0000269|PubMed:25600804"; MUTAGEN 58; /note="K->A: Loss of nuclear localization."; /evidence="ECO:0000269|PubMed:25600804"; MUTAGEN 512; /note="K->R: Partial loss of sumoylation. Almost complete loss of sumoylation, partial loss of transcription repression, no effect on subcellular location, loss of rDNA silencing; when associated with R-20."; /evidence="ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909
uniprot
proteins
post_translational_modification
PTM: Sumoylated at Lys-20 by SUMO1 and at Lys-512 by SUMO1, SUMO2 and SUMO3. Sumoylation probably occurs sequentially, with that of Lys-20 preceding that of Lys-512. It does not alter association with heterochromatin, but is required for the repression of transcription. {ECO:0000269|PubMed:21914818}.
uniprot
proteins
pubmed
10997877
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21914818
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25400923
uniprot
proteins
pubmed
25600804
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
26100909
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28977671
uniprot
proteins
sequence_length
828
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:25600804}. Nucleus, nucleolus {ECO:0000269|PubMed:26100909}. Note=In the nucleus, observed in heterochromatic foci containing CBX1, CBX3, CBX5 and histone H3 trimethylated at 'Lys-9'. Released from chromatin during decondensation. Association with heterochromatin does not depend on sumoylation. {ECO:0000269|PubMed:21914818}.
uniprot
proteins