NMU
entrez
10874
canonical
uniprot
P48645
canonical
ensembl
ENSG00000109255
resolver
ensp
ENSP00000264218
resolver
ensp
ENSP00000422399
resolver
ensp
ENSP00000422870
resolver
ensp
ENSP00000590416
resolver
ensp
ENSP00000590417
resolver
ensp
ENSP00000590419
resolver
ensp
ENSP00000590422
resolver
ensp
ENSP00000638066
resolver
enst
ENST00000264218
resolver
enst
ENST00000507338
resolver
enst
ENST00000511469
resolver
enst
ENST00000920357
resolver
enst
ENST00000920358
resolver
enst
ENST00000920363
resolver
enst
ENST00000968007
resolver
genesymbol
NMU
resolver
genesymbol_syn
NMU1
resolver
hgnc
HGNC:7859
resolver
uniprot
A0A0B4J202
resolver
uniprot
A0A250SH36
resolver
uniprot
E9PDJ7
resolver
uniprot
Q86WB6
resolver
uniprot_entry
A0A0B4J202_HUMAN
resolver
uniprot_entry
E9PDJ7_HUMAN
resolver
uniprot_entry
NMU_HUMAN
resolver
uniprot_entry
Q86WB6_HUMAN
resolver
uniprot_sec
A0A250SH36
resolver
amino_acid_sequence
MLRTESCRPRSPAGQVAAASPLLLLLLLLAWCAGACRGAPILPQGLQPEQQLQLWNEIDDTCSSFLSIDSQPQASNALEELCFMIMGMLPKPQEQDEKDNTKRFLFHYSKTQKLGKSNVVSSVVHPLLQLVPHLHERRMKRFRVDEEFQSPFASQSRGYFLFRPRNGRRSAGFI
uniprot
proteins
function
FUNCTION: [Neuromedin-U-25]: Multifunctional neuropeptide that acts via two G protein-coupled receptors, NMUR1 and NMUR2 (PubMed:15331768, PubMed:35440625). Functionally, is involved in pleiotropic roles, including regulation of feeding, energy balance, blood pressure and smooth muscle contraction (By similarity). Additionally modulates hormone release and inflammatory responses in a tissue- and receptor-dependent manner (PubMed:15585845, PubMed:33857254). Mechanistically, binding to NMUR1 or NMUR2 results in coupling of receptors to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits (PubMed:15331768). GNAQ/Gaq or GNA11/Ga11 coupling leads to the activation of a phospholipase C (PLC), which hydrolyzes PIP2 (phosphatidylinositol 4,5-bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate), and subsequent intracellular calcium mobilization via IP3 receptors on the endoplasmic reticulum (PubMed:15331768). GNAI1/Gai coupling inhibits forskolin-stimulated cAMP accumulation (PubMed:15331768). In pancreatic beta cells, regulates insulin secretion through NMUR1 coupled to GNAI2 and GNAO1, resulting in reduced intracellular Ca2+ influx and cAMP levels (PubMed:33857254). Through NMUR1 in Th2-type T cells, enhances type 2 cytokine secretion and modulates inflammatory responses via activation of PLC-calcineurin-MEK and PI3K signaling pathways (PubMed:15585845). {ECO:0000250|UniProtKB:P12760, ECO:0000250|UniProtKB:P34964, ECO:0000269|PubMed:15331768, ECO:0000269|PubMed:15585845, ECO:0000269|PubMed:33857254, ECO:0000269|PubMed:35440625}.; FUNCTION: [Neuromedin precursor-related peptide 33]: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36. {ECO:0000250|UniProtKB:P12760}.; FUNCTION: [Neuromedin precursor-related peptide 36]: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system. {ECO:0000250|UniProtKB:P12760}.
uniprot
proteins
mass_dalton
19741
uniprot
proteins
protein_family
NmU family
uniprot
proteins
pubmed
15331768
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15585845
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
28874765
uniprot
proteins
pubmed
33857254
uniprot
proteins
pubmed
35440625
uniprot
proteins
pubmed
36575163
uniprot
proteins
pubmed
7619205
uniprot
proteins
sequence_length
174
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Neuromedin-U-25]: Secreted {ECO:0000250|UniProtKB:P12760}.
uniprot
proteins