PSPH
entrez
5723
canonical
uniprot
P78330
canonical
ensembl
ENSG00000146733
resolver
ensp
ENSP00000275605
resolver
ensp
ENSP00000378854
resolver
ensp
ENSP00000401639
resolver
ensp
ENSP00000561783
resolver
ensp
ENSP00000561784
resolver
ensp
ENSP00000561785
resolver
ensp
ENSP00000561786
resolver
ensp
ENSP00000561787
resolver
ensp
ENSP00000561789
resolver
ensp
ENSP00000561791
resolver
ensp
ENSP00000561792
resolver
ensp
ENSP00000561794
resolver
ensp
ENSP00000561796
resolver
ensp
ENSP00000561797
resolver
ensp
ENSP00000561798
resolver
ensp
ENSP00000561799
resolver
ensp
ENSP00000561800
resolver
ensp
ENSP00000561801
resolver
ensp
ENSP00000561802
resolver
ensp
ENSP00000561803
resolver
ensp
ENSP00000561804
resolver
ensp
ENSP00000561805
resolver
ensp
ENSP00000561806
resolver
ensp
ENSP00000561807
resolver
ensp
ENSP00000561809
resolver
ensp
ENSP00000561810
resolver
ensp
ENSP00000561811
resolver
ensp
ENSP00000561812
resolver
ensp
ENSP00000561813
resolver
ensp
ENSP00000561814
resolver
ensp
ENSP00000561815
resolver
ensp
ENSP00000561816
resolver
ensp
ENSP00000561817
resolver
ensp
ENSP00000561818
resolver
ensp
ENSP00000561819
resolver
ensp
ENSP00000561821
resolver
ensp
ENSP00000561822
resolver
ensp
ENSP00000561823
resolver
ensp
ENSP00000561824
resolver
ensp
ENSP00000590225
resolver
ensp
ENSP00000590226
resolver
ensp
ENSP00000590227
resolver
ensp
ENSP00000590228
resolver
ensp
ENSP00000590229
resolver
ensp
ENSP00000590230
resolver
ensp
ENSP00000590231
resolver
ensp
ENSP00000590232
resolver
ensp
ENSP00000590233
resolver
ensp
ENSP00000590234
resolver
ensp
ENSP00000590235
resolver
ensp
ENSP00000590236
resolver
ensp
ENSP00000590237
resolver
ensp
ENSP00000590238
resolver
ensp
ENSP00000590239
resolver
ensp
ENSP00000590240
resolver
ensp
ENSP00000590241
resolver
ensp
ENSP00000590243
resolver
ensp
ENSP00000590245
resolver
ensp
ENSP00000590246
resolver
ensp
ENSP00000590247
resolver
ensp
ENSP00000590248
resolver
ensp
ENSP00000590249
resolver
ensp
ENSP00000590250
resolver
ensp
ENSP00000638705
resolver
ensp
ENSP00000638706
resolver
ensp
ENSP00000638707
resolver
ensp
ENSP00000638708
resolver
ensp
ENSP00000638709
resolver
ensp
ENSP00000638710
resolver
ensp
ENSP00000638711
resolver
ensp
ENSP00000638712
resolver
ensp
ENSP00000638713
resolver
ensp
ENSP00000638714
resolver
ensp
ENSP00000638715
resolver
ensp
ENSP00000638716
resolver
ensp
ENSP00000638717
resolver
ensp
ENSP00000638718
resolver
ensp
ENSP00000638719
resolver
ensp
ENSP00000638720
resolver
ensp
ENSP00000638721
resolver
ensp
ENSP00000638722
resolver
ensp
ENSP00000638723
resolver
ensp
ENSP00000638724
resolver
ensp
ENSP00000638725
resolver
ensp
ENSP00000638726
resolver
ensp
ENSP00000638727
resolver
ensp
ENSP00000638728
resolver
ensp
ENSP00000638729
resolver
ensp
ENSP00000638730
resolver
ensp
ENSP00000638731
resolver
ensp
ENSP00000638732
resolver
ensp
ENSP00000697704
resolver
enst
ENST00000275605
resolver
enst
ENST00000395471
resolver
enst
ENST00000437355
resolver
enst
ENST00000891724
resolver
enst
ENST00000891725
resolver
enst
ENST00000891726
resolver
enst
ENST00000891728
resolver
enst
ENST00000891729
resolver
enst
ENST00000891730
resolver
enst
ENST00000891732
resolver
enst
ENST00000891733
resolver
enst
ENST00000891735
resolver
enst
ENST00000891737
resolver
enst
ENST00000891738
resolver
enst
ENST00000891739
resolver
enst
ENST00000891740
resolver
enst
ENST00000891741
resolver
enst
ENST00000891742
resolver
enst
ENST00000891743
resolver
enst
ENST00000891744
resolver
enst
ENST00000891745
resolver
enst
ENST00000891746
resolver
enst
ENST00000891747
resolver
enst
ENST00000891750
resolver
enst
ENST00000891751
resolver
enst
ENST00000891752
resolver
enst
ENST00000891753
resolver
enst
ENST00000891754
resolver
enst
ENST00000891755
resolver
enst
ENST00000891756
resolver
enst
ENST00000891757
resolver
enst
ENST00000891758
resolver
enst
ENST00000891759
resolver
enst
ENST00000891760
resolver
enst
ENST00000891762
resolver
enst
ENST00000891763
resolver
enst
ENST00000891764
resolver
enst
ENST00000891765
resolver
enst
ENST00000920167
resolver
enst
ENST00000920168
resolver
enst
ENST00000920169
resolver
enst
ENST00000920170
resolver
enst
ENST00000920171
resolver
enst
ENST00000920172
resolver
enst
ENST00000920173
resolver
enst
ENST00000920174
resolver
enst
ENST00000920175
resolver
enst
ENST00000920176
resolver
enst
ENST00000920177
resolver
enst
ENST00000920178
resolver
enst
ENST00000920180
resolver
enst
ENST00000920181
resolver
enst
ENST00000920182
resolver
enst
ENST00000920184
resolver
enst
ENST00000920186
resolver
enst
ENST00000920187
resolver
enst
ENST00000920188
resolver
enst
ENST00000920189
resolver
enst
ENST00000920191
resolver
enst
ENST00000968646
resolver
enst
ENST00000968647
resolver
enst
ENST00000968648
resolver
enst
ENST00000968649
resolver
enst
ENST00000968651
resolver
enst
ENST00000968652
resolver
enst
ENST00000968653
resolver
enst
ENST00000968654
resolver
enst
ENST00000968655
resolver
enst
ENST00000968656
resolver
enst
ENST00000968657
resolver
enst
ENST00000968658
resolver
enst
ENST00000968659
resolver
enst
ENST00000968660
resolver
enst
ENST00000968662
resolver
enst
ENST00000968663
resolver
enst
ENST00000968664
resolver
enst
ENST00000968665
resolver
enst
ENST00000968666
resolver
enst
ENST00000968667
resolver
enst
ENST00000968668
resolver
enst
ENST00000968669
resolver
enst
ENST00000968670
resolver
enst
ENST00000968671
resolver
enst
ENST00000968672
resolver
enst
ENST00000968673
resolver
genesymbol
PSPH
resolver
hgnc
HGNC:9577
resolver
uniprot
B2RCR5
resolver
uniprot
Q7Z3S5
resolver
uniprot_entry
SERB_HUMAN
resolver
uniprot_sec
B2RCR5
resolver
uniprot_sec
Q7Z3S5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by calcium ions. {ECO:0000269|PubMed:15291819}.
uniprot
proteins
amino_acid_sequence
MVSHSELRKLFYSADAVCFDVDSTVIREEGIDELAKICGVEDAVSEMTRRAMGGAVPFKAALTERLALIQPSREQVQRLIAEQPPHLTPGIRELVSRLQERNVQVFLISGGFRSIVEHVASKLNIPATNVFANRLKFYFNGEYAGFDETQPTAESGGKGKVIKLLKEKFHFKKIIMIGDGATDMEACPPADAFIGFGGNVIRQQVKDNAKWYITDFVELLGELEE
uniprot
proteins
disease_involvement
DISEASE: Phosphoserine phosphatase deficiency (PSPHD) [MIM:614023]: An autosomal recessive disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome. {ECO:0000269|PubMed:14673469, ECO:0000269|PubMed:25080166, ECO:0000269|PubMed:9222972}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.3.3
uniprot
proteins
function
FUNCTION: Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine (PubMed:12213811, PubMed:14673469, PubMed:15291819, PubMed:25080166, PubMed:9222972). L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator (PubMed:14673469). May also act on O-phospho-D-serine (Probable). {ECO:0000269|PubMed:12213811, ECO:0000269|PubMed:14673469, ECO:0000269|PubMed:15291819, ECO:0000269|PubMed:25080166, ECO:0000269|PubMed:9222972, ECO:0000303|PubMed:14673469, ECO:0000305|PubMed:1965857}.
uniprot
proteins
mass_dalton
25008
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="S->A: Reduces L-phosphoserine phosphatase activity by about 50%."; /evidence="ECO:0000269|PubMed:12213811"; MUTAGEN 23; /note="S->T: Reduces L-phosphoserine phosphatase activity by about 80%."; /evidence="ECO:0000269|PubMed:12213811"; MUTAGEN 29; /note="E->D: Reduces L-phosphoserine phosphatase activity by about 95%."; /evidence="ECO:0000269|PubMed:12213811"; MUTAGEN 29; /note="E->Q: Loss of L-phosphoserine phosphatase activity."; /evidence="ECO:0000269|PubMed:12213811"; MUTAGEN 65; /note="R->A,K: Loss of L-phosphoserine phosphatase activity."; /evidence="ECO:0000269|PubMed:12213811"; MUTAGEN 133; /note="N->A: Reduces L-phosphoserine phosphatase activity by about 75%."; /evidence="ECO:0000269|PubMed:12213811"; MUTAGEN 182; /note="T->S: Reduces L-phosphoserine phosphatase activity by about 99%."; /evidence="ECO:0000269|PubMed:12213811"; MUTAGEN 182; /note="T->V: Reduces L-phosphoserine phosphatase activity by about 25%."; /evidence="ECO:0000269|PubMed:12213811"; MUTAGEN 202; /note="R->A: Reduces L-phosphoserine phosphatase activity by about 99%."; /evidence="ECO:0000269|PubMed:12213811"; MUTAGEN 202; /note="R->K: Reduces L-phosphoserine phosphatase activity by about 95%."; /evidence="ECO:0000269|PubMed:12213811
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3. {ECO:0000269|PubMed:14673469, ECO:0000269|PubMed:25080166, ECO:0000269|PubMed:9222972}.
uniprot
proteins
protein_family
HAD-like hydrolase superfamily
uniprot
proteins
protein_family
SerB family
uniprot
proteins
pubmed
12213811
uniprot
proteins
pubmed
12777757
uniprot
proteins
pubmed
14673469
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15291819
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
1965857
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25080166
uniprot
proteins
pubmed
31205021
uniprot
proteins
pubmed
9188776
uniprot
proteins
pubmed
9222972
uniprot
proteins
sequence_length
225
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:1965857}.
uniprot
proteins