Slc6a6
entrez
29464
canonical
uniprot
P31643
canonical
ensembl
ENSRNOG00000009019
resolver
ensembl
ENSRNOG00055004410
resolver
ensembl
ENSRNOG00060027547
resolver
ensembl
ENSRNOG00065024758
resolver
ensp
ENSRNOP00000012875
resolver
ensp
ENSRNOP00000072080
resolver
ensp
ENSRNOP00055005212
resolver
ensp
ENSRNOP00060039787
resolver
ensp
ENSRNOP00065034810
resolver
enst
ENSRNOT00055006981
resolver
enst
ENSRNOT00060047837
resolver
enst
ENSRNOT00065042545
resolver
genesymbol
Slc6a6
resolver
uniprot_entry
SC6A6_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Taurine transport activity is stimulated by thyrotropin (By similarity). Taurine transport activity is inhibited by GABA, hypotaurine and beta-alanine (PubMed:1435737). GABA transport activity is inhibited by taurine and beta-alanine (PubMed:18501699). Taurine transport activity is inhibited by L-alanine, guanidinoethane sulfonate (GES), piperidine-4-sulfonic acid, imidazole-4-acetatic acid, 5-aminovaleric acid, nipecotic acid, homotaurine and phorbol 12-myristate 13-acetate (By similarity). Taurine transport activity is stimulated by hypertonic stress (By similarity). {ECO:0000250|UniProtKB:P31641, ECO:0000250|UniProtKB:Q9MZ34, ECO:0000269|PubMed:1435737, ECO:0000269|PubMed:18501699}.
uniprot
proteins
amino_acid_sequence
MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEADGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFQSFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLSAANFTSPVIEFWERNVLSLSSGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPNISRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAIVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPALCVGCFIFSLVKYVPLTYNKVYRYPDWAIGLGWGLALSSMVCIPLVIVILLCRTEGPLRVRIKYLITPREPNRWAVEREGATPFHSRATLMNGALMKPSHVIVETMM
uniprot
proteins
function
FUNCTION: Mediates sodium- and chloride-dependent transport of taurine, a key amino acid (PubMed:1435737, PubMed:18501699, PubMed:22896705). Taurine acts as an anti-aging agent by reducing cellular senescence and combating oxidative stress: levels decline with age and supplementation has been shown to extend lifespan (By similarity). In addition to mediate extracellular taurine uptake, also able to mediate transport of taurine into mitochondria, sustaining mitochondrial translation (By similarity). Can also mediate transport of beta-alanine, hypotaurine and gamma-aminobutyric acid (GABA) (PubMed:18501699). {ECO:0000250|UniProtKB:O35316, ECO:0000250|UniProtKB:P31641, ECO:0000269|PubMed:1435737, ECO:0000269|PubMed:18501699, ECO:0000269|PubMed:22896705}.
uniprot
proteins
mass_dalton
69869
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-21 and Ser-25 by PKA promotes localization at the plasma while inhibiting mitochondrial localization (By similarity). Taurine transport activity is down-regulated upon Ser-322 phosphorylation (By similarity). {ECO:0000250|UniProtKB:P31641, ECO:0000250|UniProtKB:Q00589}.
uniprot
proteins
protein_family
SLC6A6 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
1435737
uniprot
proteins
pubmed
18501699
uniprot
proteins
pubmed
22896705
uniprot
proteins
sequence_length
621
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18501699}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31641}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P31641}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31641}. Note=Phosphorylation at Ser-21 and Ser-25 by PKA promotes localization at the plasma while inhibiting mitochondrial localization. {ECO:0000250|UniProtKB:P31641}.
uniprot
proteins
transmembrane_region
TRANSMEM 50..70; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P31641"; TRANSMEM 79..102; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P31641"; TRANSMEM 128..150; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P31641"; TRANSMEM 216..236; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P31641"; TRANSMEM 245..265; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P31641"; TRANSMEM 290..310; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P31641"; TRANSMEM 337..352; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P31641"; TRANSMEM 380..400; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P31641"; TRANSMEM 430..458; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P31641"; TRANSMEM 465..482; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P31641"; TRANSMEM 506..525; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P31641"; TRANSMEM 545..563; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P31641
uniprot
proteins