Kat6a
entrez
306571
canonical
uniprot
Q5TKR9
canonical
ensembl
ENSRNOG00000025174
resolver
ensembl
ENSRNOG00055007618
resolver
ensembl
ENSRNOG00060027715
resolver
ensembl
ENSRNOG00065008705
resolver
ensp
ENSRNOP00000071789
resolver
ensp
ENSRNOP00055010169
resolver
ensp
ENSRNOP00060040071
resolver
ensp
ENSRNOP00065010308
resolver
enst
ENSRNOT00000078743
resolver
enst
ENSRNOT00055012752
resolver
enst
ENSRNOT00060048150
resolver
enst
ENSRNOT00065013860
resolver
genesymbol
Kat6a
resolver
genesymbol_syn
Moz
resolver
genesymbol_syn
Myst3
resolver
uniprot_entry
KAT6A_RAT
resolver
amino_acid_sequence
MVKLANPLYTQWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQSVDWNKLLKRAFEGLAESGGSTLKSIERFLKSQKDVSAACGGTAASGFHQQLRLAIKRAVGHGRLLKDGPLYRLNTKAANAEGKEGCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEDLISCADCGNSGHPSCLKFSPELTVRVRALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYANPIGRPKNRLKKQSTVSKGPFSKVRTGPGRGRKRKITVSSQSASSSEEGYLERIDGLDFCRDSSAPLKFNKKTKGLIDGLTKFFTPSPDGRKARGEAVDYSELRIRKKGNRKSSTSHWPTDNQDGWESKQESEERLFGSQEIMTERDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGVCPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEDEEADDGEKEEPQGQERELETRERVGKSVSRENKDQDSSSLIESEKKPEVKELASSSRLSKQALVRDSLPANSQPPRRGRCGRKNRKTQERFGDKDSKMLVGETLSTSQEQYGECEEKSAASRERYTEVGEQPAAPQAQADGNPDIPKGRFSESADLWRGQLKKSPETLKCRLPEGNDRLPCCYTDGDRAVFRGFSESSEEEEEPESPRSNSPPVLTKPTLKRKKPILHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIEEEEEEEDENELFPRGYFHCLSSQDILRCQASSKRTASKDEEEEEEESDDADDTPVLKPVSLLRKCDVNSASLEPDTSTPMKKKKGWPKGKSRKPIHWKKRPGRKPGFKLNQDIIAVSTQECIVEPIVPIKPGRKPRTQESEELVEVKEGLVEERKEEMHTEADEEAEEEEDAASSDIRAMSPLDSSNSPDADPKEPEAEEEEEKPLDDPRQSEEEPQELEEQEQEEEDEVTAEANQNEDHDADDEDDGHLDSLKTKEPEGQPAREDGTEEPGTQESFLDASIQDSRENAKDKDETEADSEEEQPSHEASVGSETMPGSEEDHEEDSNTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTHTDEDPQMSMVEDCHASEHNSPISSIPSHPSQSVRSVSSPSMPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGSSICGNNSSQSSCSYGGLSSSSSLTQNSCVVTQQMASMGNSCSMLQQNSVQPATNCNIKSPQTCVVERPPSNQQPPPPPPPPPPPQQPQPQPQQQAAPQPPPPQPQQQPPPPPQQQPQPPPPPQQQPPLSQCSMNNSFTAAPMIMEIPESGGTGNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPLAGTPQAQATMTPPPNLAPTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSKSAPLPSATAHQQQLYGRSPPAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLNAMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTGPSHHSYMNAAGVPKQSLNGPYMRR
uniprot
proteins
ec_number
2.3.1.48
uniprot
proteins
function
FUNCTION: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro) (By similarity). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2 (By similarity). Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML (By similarity). May play a role in leukemogenic gene transcription (By similarity). {ECO:0000250|UniProtKB:Q92794}.
uniprot
proteins
mass_dalton
223331
uniprot
proteins
post_translational_modification
PTM: Autoacetylated; autoacetylation at Lys-602 is required for proper function (By similarity). Acetylation at Lys-1006 and Lys-1013 is required for the interaction with MLLT1/ENL and MLLT3/AF9 (By similarity). {ECO:0000250|UniProtKB:Q9H7Z6}.; PTM: Crotonylated; crotonylation at Lys-1006 and Lys-1013 promotes the interaction with MLLT1/ENL and MLLT3/AF9. {ECO:0000250|UniProtKB:Q9H7Z6}.; PTM: Phosphorylation at Thr-369 by PKB/AKT1 inhibits its interaction with PML and negatively regulates its acetylation activity towards p53/TP53. {ECO:0000250}.
uniprot
proteins
protein_family
MYST (SAS/MOZ) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1998
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q92794}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q92794}. Nucleus, PML body {ECO:0000250|UniProtKB:Q92794}. Note=Recruited into PML body after DNA damage. {ECO:0000250|UniProtKB:Q92794}.
uniprot
proteins