GAR1
entrez
54433
canonical
uniprot
Q9NY12
canonical
ensembl
ENSG00000109534
resolver
ensp
ENSP00000226796
resolver
ensp
ENSP00000378127
resolver
ensp
ENSP00000533578
resolver
genesymbol
GAR1
resolver
genesymbol_syn
NOLA1
resolver
hgnc
HGNC:14264
resolver
uniprot
Q5MJQ2
resolver
uniprot_entry
GAR1_HUMAN
resolver
uniprot_sec
Q5MJQ2
resolver
amino_acid_sequence
MSFRGGGRGGFNRGGGGGGFNRGGSSNHFRGGGGGGGGGNFRGGGRGGFGRGGGRGGFNKGQDQGPPERVVLLGEFLHPCEDDIVCKCTTDENKVPYFNAPVYLENKEQIGKVDEIFGQLRDFYFSVKLSENMKASSFKKLQKFYIDPYKLLPLQRFLPRPPGEKGPPRGGGRGGRGGGRGGGGRGGGRGGGFRGGRGGGGGGFRGGRGGGFRGRGH
uniprot
proteins
function
FUNCTION: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO:0000269|PubMed:10757788, ECO:0000269|PubMed:15044956}.
uniprot
proteins
mass_dalton
22348
uniprot
proteins
protein_family
GAR1 family
uniprot
proteins
pubmed
10757788
uniprot
proteins
pubmed
11509230
uniprot
proteins
pubmed
11790298
uniprot
proteins
pubmed
12244096
uniprot
proteins
pubmed
15044956
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19179534
uniprot
proteins
pubmed
20351177
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29695869
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
uniprot
proteins