Plpp5
entrez
71910
canonical
uniprot
Q3UMZ3
canonical
ensembl
ENSMUSG00000031570
resolver
ensp
ENSMUSP00000067035
resolver
ensp
ENSMUSP00000122437
resolver
genesymbol
Plpp5
resolver
genesymbol_syn
Ppapdc1
resolver
genesymbol_syn
Ppapdc1b
resolver
uniprot
Q4KL19
resolver
uniprot
Q6P6K4
resolver
uniprot_entry
PLPP5_MOUSE
resolver
uniprot_entry
Q6P6K4_MOUSE
resolver
uniprot_sec
Q4KL19
resolver
activity_regulation
ACTIVITY REGULATION: Magnesium-independent phospholipid phosphatase. Inhibited by N-ethylmaleimide. {ECO:0000250|UniProtKB:Q8NEB5}.
uniprot
proteins
amino_acid_sequence
MGTAALGAELGVRVLLFVAFLVTELLPPFQRRIQPEELWLYRNPYVEAEYFPTGRMFVIAFLTPLSLIFLAKFLRKADATDSKQACLAASLALALNGVFTNIIKLIVGRPRPDFFYRCFPDGLAHSDLTCTGDEDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPQGRGKSWRLCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPPLTDVECHKPFQDKHKLPSSQKPSELHHLEI
uniprot
proteins
ec_number
3.1.3.4
uniprot
proteins
ec_number
3.6.1.75
uniprot
proteins
function
FUNCTION: Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules. {ECO:0000250|UniProtKB:Q8NEB5}.
uniprot
proteins
mass_dalton
29223
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000250|UniProtKB:Q8NEB5}.
uniprot
proteins
protein_family
PA-phosphatase related phosphoesterase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
30042348
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30042348}; Multi-pass membrane protein {ECO:0000269|PubMed:30042348}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..71; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 151..171; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 176..196; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 206..223; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins