Grm1
entrez
24414
canonical
uniprot
P23385
canonical
ensembl
ENSRNOG00000014290
resolver
ensembl
ENSRNOG00055001767
resolver
ensembl
ENSRNOG00060006069
resolver
ensembl
ENSRNOG00065025066
resolver
ensp
ENSRNOP00000019319
resolver
ensp
ENSRNOP00000047790
resolver
enst
ENSRNOT00000019319
resolver
genesymbol
Grm1
resolver
genesymbol_syn
Gprc1a
resolver
genesymbol_syn
Mglur1
resolver
genesymbol_syn
mGluR1b
resolver
genesymbol_syn
mGluR1f
resolver
uniprot
G3V7U1
resolver
uniprot
Q9WTJ1
resolver
uniprot_entry
G3V7U1_RAT
resolver
uniprot_entry
GRM1_RAT
resolver
uniprot_entry
Q9WTJ1_RAT
resolver
amino_acid_sequence
MVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPIPVRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVWQRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSAHFSPPSSPSMVVHRRGPPVATTPPLPPHLTAEETPLFLADSVIPKGLPPPLPQQQPQQPPPQQPPQQPKSLMDQLQGVVTNFGSGIPDFHAVLAGPGTPGNSLRSLYPPPPPPQHLQMLPLHLSTFQEESISPPGEDIDDDSERFKLLQEFVYEREGNTEEDELEEEEDLPTASKLTPEDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILRDYKQSSSTL
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:10945991, PubMed:1438218, PubMed:1656524, PubMed:1847995). May function in the light response in the retina (By similarity). Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell, respectively (By similarity). {ECO:0000250|UniProtKB:P97772, ECO:0000250|UniProtKB:Q13255, ECO:0000269|PubMed:10945991, ECO:0000269|PubMed:1438218, ECO:0000269|PubMed:1656524, ECO:0000269|PubMed:1847995}.
uniprot
proteins
mass_dalton
133236
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="C->S: Impairs protein folding and abolishes location at the cell surface."; /evidence="ECO:0000269|PubMed:10945991"; MUTAGEN 109; /note="C->S: Impairs protein folding and abolishes location at the cell surface."; /evidence="ECO:0000269|PubMed:10945991"; MUTAGEN 140; /note="C->S: Impairs homodimerization."; /evidence="ECO:0000269|PubMed:10945991
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
pubmed
10469171
uniprot
proteins
pubmed
10945991
uniprot
proteins
pubmed
11069170
uniprot
proteins
pubmed
11850456
uniprot
proteins
pubmed
11867751
uniprot
proteins
pubmed
1309649
uniprot
proteins
pubmed
1438218
uniprot
proteins
pubmed
1656524
uniprot
proteins
pubmed
1847995
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13255}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P97772}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:P97772}. Note=Located in dendrioles, small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell. {ECO:0000250|UniProtKB:P97772}.
uniprot
proteins
transmembrane_region
TRANSMEM 593..615; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 630..650; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 659..680; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 704..727; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 751..772; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 786..807; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 816..840; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins