ACAP2
entrez
23527
canonical
uniprot
Q15057
canonical
ensembl
ENSG00000114331
resolver
ensp
ENSP00000324287
resolver
ensp
ENSP00000412338
resolver
ensp
ENSP00000537171
resolver
ensp
ENSP00000537173
resolver
ensp
ENSP00000537176
resolver
ensp
ENSP00000537179
resolver
enst
ENST00000326793
resolver
genesymbol
ACAP2
resolver
genesymbol_syn
CENTB2
resolver
genesymbol_syn
KIAA0041
resolver
hgnc
HGNC:16469
resolver
uniprot
A8K2V4
resolver
uniprot
Q8N5Z8
resolver
uniprot
Q9UQR3
resolver
uniprot_entry
ACAP2_HUMAN
resolver
uniprot_sec
A8K2V4
resolver
uniprot_sec
Q8N5Z8
resolver
uniprot_sec
Q9UQR3
resolver
activity_regulation
ACTIVITY REGULATION: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid. {ECO:0000269|PubMed:11062263}.
uniprot
proteins
amino_acid_sequence
MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATNILTATRKCFRHIALDYVLQINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQPGQRQEKEAYIRAKYVERKFVDKYSISLSPPEQQKKFVSKSSEEKRLSISKFGPGDQVRASAQSSVRSNDSGIQQSSDDGRESLPSTVSANSLYEPEGERQDSSMFLDSKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQDSQKF
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35 (PubMed:30905672). {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:30905672}.
uniprot
proteins
mass_dalton
88029
uniprot
proteins
mutagenesis
MUTAGEN 442; /note="R->Q: Loss of GAP activity."; /evidence="ECO:0000269|PubMed:11062263"; MUTAGEN 721; /note="D->A: Strong decrease in interaction with RAB35."; /evidence="ECO:0000269|PubMed:30905672"; MUTAGEN 727; /note="R->A: Decreased interaction with RAB35."; /evidence="ECO:0000269|PubMed:30905672"; MUTAGEN 727; /note="R->H: Loss of interaction with RAB35."; /evidence="ECO:0000269|PubMed:30905672"; MUTAGEN 731; /note="M->A: Strong decrease in interaction with RAB35."; /evidence="ECO:0000269|PubMed:30905672"; MUTAGEN 756; /note="D->K: Decreased interaction with RAB35."; /evidence="ECO:0000269|PubMed:30905672
uniprot
proteins
pubmed
11062263
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30905672
uniprot
proteins
pubmed
7584044
uniprot
proteins
sequence_length
778
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30905672}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with RAB35 at the membrane protrusions of HEK293T cells. {ECO:0000269|PubMed:30905672}.
uniprot
proteins