PAFAH2
entrez
5051
canonical
uniprot
Q99487
canonical
ensembl
ENSG00000158006
resolver
ensp
ENSP00000363400
resolver
ensp
ENSP00000363402
resolver
ensp
ENSP00000542761
resolver
ensp
ENSP00000542767
resolver
ensp
ENSP00000542768
resolver
ensp
ENSP00000542769
resolver
ensp
ENSP00000601186
resolver
ensp
ENSP00000601187
resolver
ensp
ENSP00000612609
resolver
ensp
ENSP00000612610
resolver
enst
ENST00000374282
resolver
enst
ENST00000374284
resolver
enst
ENST00000872702
resolver
enst
ENST00000872708
resolver
enst
ENST00000872709
resolver
enst
ENST00000872710
resolver
enst
ENST00000931127
resolver
enst
ENST00000931128
resolver
enst
ENST00000942550
resolver
enst
ENST00000942551
resolver
genesymbol
PAFAH2
resolver
hgnc
HGNC:8579
resolver
uniprot
D3DPK1
resolver
uniprot
O15458
resolver
uniprot
Q5SY02
resolver
uniprot_entry
PAFA2_HUMAN
resolver
uniprot_sec
D3DPK1
resolver
uniprot_sec
O15458
resolver
uniprot_sec
Q5SY02
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by phenylmethanesulfonyl fluoride, 3,4,dichloroisocoumarin, diisopropyl fluorophosphate (DFP) and diethyl p-nitrophenyl phosphate (DENP). {ECO:0000269|PubMed:9494101}.
uniprot
proteins
amino_acid_sequence
MGVNQSVGFPPVTGPHLVGCGDVMEGQNLQGSFFRLFYPCQKAEETMEQPLWIPRYEYCTGLAEYLQFNKRCGGLLFNLAVGSCRLPVSWNGPFKTKDSGYPLIIFSHGLGAFRTLYSAFCMELASRGFVVAVPEHRDRSAATTYFCKQAPEENQPTNESLQEEWIPFRRVEEGEKEFHVRNPQVHQRVSECLRVLKILQEVTAGQTVFNILPGGLDLMTLKGNIDMSRVAVMGHSFGGATAILALAKETQFRCAVALDAWMFPLERDFYPKARGPVFFINTEKFQTMESVNLMKKICAQHEQSRIITVLGSVHRSQTDFAFVTGNLIGKFFSTETRGSLDPYEGQEVMVRAMLAFLQKHLDLKEDYNQWNNLIEGIGPSLTPGAPHHLSSL
uniprot
proteins
ec_number
2.3.1.149
uniprot
proteins
ec_number
3.1.1.47
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (PubMed:9494101). Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (By similarity). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity). {ECO:0000250|UniProtKB:P79106, ECO:0000250|UniProtKB:P83006, ECO:0000269|PubMed:9494101}.
uniprot
proteins
mass_dalton
44036
uniprot
proteins
protein_family
Serine esterase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
8955149
uniprot
proteins
pubmed
9218411
uniprot
proteins
pubmed
9494101
uniprot
proteins
sequence_length
392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9494101}. Membrane {ECO:0000250|UniProtKB:P79106}; Lipid-anchor {ECO:0000250|UniProtKB:P79106}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P79106}; Lipid-anchor {ECO:0000250|UniProtKB:P79106}. Note=In resting cells, localizes to intracellular membranes and cytoplasm. Translocates from the cytoplasm to intracellular membranes upon oxidative stress. {ECO:0000250|UniProtKB:P79106}.
uniprot
proteins