Cdo1
entrez
12583
canonical
uniprot
P60334
canonical
ensembl
ENSMUSG00000033022
resolver
ensp
ENSMUSP00000046517
resolver
enst
ENSMUST00000035804
resolver
genesymbol
Cdo1
resolver
uniprot
Q3UED8
resolver
uniprot_entry
CDO1_MOUSE
resolver
uniprot_sec
Q3UED8
resolver
amino_acid_sequence
MERTELLKPRTLADLIRILHELFAGDEVNVEEVQAVLEAYESNPAEWALYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKETLFDWPDKKSNEMIKKSERTLRENQCAYINDSIGLHRVENVSHTEPAVSLHLYSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTPFTTSGSLENN
uniprot
proteins
ec_number
1.13.11.20
uniprot
proteins
function
FUNCTION: Rate-limiting enzyme of the cysteine catabolic process to taurine, which catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen. {ECO:0000269|PubMed:16492780}.
uniprot
proteins
mass_dalton
23026
uniprot
proteins
pathway_participation
PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.
uniprot
proteins
post_translational_modification
PTM: The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen. {ECO:0000269|PubMed:16492780}.; PTM: Ubiquitinated and degraded by the ECS(LRRC58) complex, leading to its degradation. L-cysteine abundance regulates ECS(LRRC58)-mediated ubiquitination of CDO1: the complex promotes ubiquitination and degradation of CDO1 in presence of high level of cysteine, but not when cysteine abundance is low. {ECO:0000250|UniProtKB:Q16878}.
uniprot
proteins
protein_family
Cysteine dioxygenase family
uniprot
proteins
pubmed
11602353
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16492780
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
200
uniprot
proteins