BPNT1
entrez
10380
canonical
uniprot
O95861
canonical
ensembl
ENSG00000162813
resolver
ensp
ENSP00000318852
resolver
ensp
ENSP00000410348
resolver
ensp
ENSP00000444398
resolver
ensp
ENSP00000586852
resolver
ensp
ENSP00000746936
resolver
genesymbol
BPNT1
resolver
genesymbol
HEL20
resolver
hgnc
HGNC:1096
resolver
uniprot
A8K7C8
resolver
uniprot
B4DPS5
resolver
uniprot
B4DUS9
resolver
uniprot
B7Z9J7
resolver
uniprot
D3DTA9
resolver
uniprot
Q8WVL5
resolver
uniprot
Q9UGJ3
resolver
uniprot
V9HWF9
resolver
uniprot_entry
B7Z9J7_HUMAN
resolver
uniprot_entry
BPNT1_HUMAN
resolver
uniprot_entry
V9HWF9_HUMAN
resolver
uniprot_sec
A8K7C8
resolver
uniprot_sec
B4DPS5
resolver
uniprot_sec
B4DUS9
resolver
uniprot_sec
D3DTA9
resolver
uniprot_sec
Q8WVL5
resolver
uniprot_sec
Q9UGJ3
resolver
activity_regulation
ACTIVITY REGULATION: Is very sensitive to inhibition by Li(+) (IC(50)=0.3 mM for hydrolysis of PAP; IC(50)=0.6 mM for hydrolysis of inositol-1,4-bis-phosphate). Is not affected by high Na(+) concentrations. {ECO:0000269|PubMed:10675562}.
uniprot
proteins
amino_acid_sequence
MASSNTVLMRLVASAYSIAQKAGMIVRRVIAEGDLGIVEKTCATDLQTKADRLAQMSICSSLARKFPKLTIIGEEDLPSEEVDQELIEDSQWEEILKQPCPSQYSAIKEEDLVVWVDPLDGTKEYTEGLLDNVTVLIGIAYEGKAIAGVINQPYYNYEAGPDAVLGRTIWGVLGLGAFGFQLKEVPAGKHIITTTRSHSNKLVTDCVAAMNPDAVLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILHAVGGKLTDIHGNVLQYHKDVKHMNSAGVLATLRNYDYYASRVPESIKNALVP
uniprot
proteins
ec_number
3.1.3.57
uniprot
proteins
ec_number
3.1.3.7
uniprot
proteins
function
FUNCTION: Phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and inositol 1,4-bisphosphate (Ins(1,4)P2) to inositol 4-phosphate (PubMed:10675562). Is also able to hydrolyze adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) (By similarity). Probably prevents the toxic accumulation of PAP, a compound which inhibits a variety of proteins, including PAPS-utilizing enzymes such as sulfotransferases, and RNA processing enzymes. Could also play a role in inositol recycling and phosphoinositide metabolism. Is not active on 3'-AMP, inositol-1-phosphate and inositol-1,4,5-triphosphate (PubMed:10675562). {ECO:0000250|UniProtKB:Q9Z1N4, ECO:0000269|PubMed:10675562}.
uniprot
proteins
mass_dalton
33392
uniprot
proteins
protein_family
Inositol monophosphatase superfamily
uniprot
proteins
pubmed
10224133
uniprot
proteins
pubmed
10675562
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
308
uniprot
proteins