Il15
entrez
16168
canonical
uniprot
P48346
canonical
ensembl
ENSMUSG00000031712
resolver
ensp
ENSMUSP00000034148
resolver
ensp
ENSMUSP00000147848
resolver
ensp
ENSMUSP00000148256
resolver
ensp
ENSMUSP00000242405
resolver
ensp
ENSMUSP00000242406
resolver
ensp
ENSMUSP00000242408
resolver
ensp
ENSMUSP00000242410
resolver
ensp
ENSMUSP00000242418
resolver
ensp
ENSMUSP00000242419
resolver
ensp
ENSMUSP00000242421
resolver
ensp
ENSMUSP00000242423
resolver
enst
ENSMUST00000034148
resolver
enst
ENSMUST00000209363
resolver
enst
ENSMUST00000209573
resolver
genesymbol
Il15
resolver
uniprot
Q1AHQ6
resolver
uniprot
Q1AHQ7
resolver
uniprot
Q3U1Z6
resolver
uniprot_entry
IL15_MOUSE
resolver
uniprot_entry
Q1AHQ6_MOUSE
resolver
uniprot_entry
Q1AHQ7_MOUSE
resolver
uniprot_entry
Q3U1Z6_MOUSE
resolver
amino_acid_sequence
MKILKPYMRNTSISCYLCFLLNSHFLTEAGIHVFILGCVSVGLPKTEANWIDVRYDLEKIESLIQSIHIDTTLYTDSDFHPSCKVTAMNCFLLELQVILHEYSNMTLNETVRNVLYLANSTLSSNKNVAESGCKECEELEEKTFTEFLQSFIRIVQMFINTS
uniprot
proteins
function
FUNCTION: Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:11466332, PubMed:8757333). Stimulates the proliferation and activation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines (PubMed:8757333). In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection (By similarity). Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (PubMed:10882748, PubMed:19632221). {ECO:0000250|UniProtKB:P40933, ECO:0000269|PubMed:10882748, ECO:0000269|PubMed:11466332, ECO:0000269|PubMed:19632221, ECO:0000269|PubMed:8757333}.
uniprot
proteins
mass_dalton
18593
uniprot
proteins
protein_family
IL-15/IL-21 family
uniprot
proteins
pubmed
10882748
uniprot
proteins
pubmed
11466332
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17947230
uniprot
proteins
pubmed
19632221
uniprot
proteins
pubmed
7759105
uniprot
proteins
pubmed
8757333
uniprot
proteins
sequence_length
162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins