LAX1
entrez
54900
canonical
uniprot
Q8IWV1
canonical
ensembl
ENSG00000122188
resolver
ensp
ENSP00000356186
resolver
ensp
ENSP00000406970
resolver
genesymbol
LAX1
resolver
genesymbol_syn
LAX
resolver
hgnc
HGNC:26005
resolver
uniprot
B7Z744
resolver
uniprot
J3KP69
resolver
uniprot
Q6NSZ6
resolver
uniprot
Q9NXB4
resolver
uniprot_entry
LAX1_HUMAN
resolver
uniprot_sec
B7Z744
resolver
uniprot_sec
J3KP69
resolver
uniprot_sec
Q6NSZ6
resolver
uniprot_sec
Q9NXB4
resolver
amino_acid_sequence
MDGVTPTLSTIRGRTLESSTLHVTPRSLDRNKDQITNIFSGFAGLLAILLVVAVFCILWNWNKRKKRQVPYLRVTVMPLLTLPQTRQRAKNIYDILPWRQEDLGRHESRSMRIFSTESLLSRNSESPEHVPSQAGNAFQEHTAHIHATEYAVGIYDNAMVPQMCGNLTPSAHCINVRASRDCASISSEDSHDYVNVPTAEEIAETLASTKSPSRNLFVLPSTQKLEFTEERDEGCGDAGDCTSLYSPGAEDSDSLSNGEGSSQISNDYVNMTGLDLSAIQERQLWVAFQCCRDYENVPAADPSGSQQQAEKDVPSSNIGHVEDKTDDPGTHVQCVKRTFLASGDYADFQPFTQSEDSQMKHREEMSNEDSSDYENVLTAKLGGRDSEQGPGTQLLPDE
uniprot
proteins
function
FUNCTION: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. {ECO:0000269|PubMed:12359715}.
uniprot
proteins
mass_dalton
44085
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines by Syk, Lck or ZAP70 upon TCR or BCR activation; which leads to the recruitment of GRB2, PIK3R1 and GRAP2. {ECO:0000269|PubMed:12359715}.
uniprot
proteins
pubmed
12359715
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15843560
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19690332
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12359715}; Single-pass type III membrane protein {ECO:0000269|PubMed:12359715}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins