Rffl
entrez
67338
canonical
uniprot
Q6ZQM0
canonical
ensembl
ENSMUSG00000020696
resolver
ensp
ENSMUSP00000021036
resolver
ensp
ENSMUSP00000071150
resolver
ensp
ENSMUSP00000074108
resolver
ensp
ENSMUSP00000091510
resolver
ensp
ENSMUSP00000103808
resolver
ensp
ENSMUSP00000276570
resolver
ensp
ENSMUSP00000276572
resolver
ensp
ENSMUSP00000276579
resolver
ensp
ENSMUSP00000276585
resolver
enst
ENSMUST00000071152
resolver
genesymbol
Rffl
resolver
uniprot
F8WHF6
resolver
uniprot
Q148A8
resolver
uniprot
Q3TEV8
resolver
uniprot
Q3UCG9
resolver
uniprot
Q3UD78
resolver
uniprot
Q5SVC2
resolver
uniprot
Q5SVC4
resolver
uniprot
Q9D543
resolver
uniprot
Q9D9B1
resolver
uniprot_entry
F8WHF6_MOUSE
resolver
uniprot_entry
Q148A8_MOUSE
resolver
uniprot_entry
Q3TEV8_MOUSE
resolver
uniprot_entry
Q3UCG9_MOUSE
resolver
uniprot_entry
Q3UD78_MOUSE
resolver
uniprot_entry
RFFL_MOUSE
resolver
uniprot_sec
Q5SVC2
resolver
uniprot_sec
Q5SVC4
resolver
uniprot_sec
Q9D543
resolver
uniprot_sec
Q9D9B1
resolver
amino_acid_sequence
MSQPSLWKDSHYFIMWASCCNWFCLDGQPEEAPPPQGARTQAYSNPGYSSFPSPTGSEPSCKACGVHFASTTRKQTCLDCKKNFCMTCSSQEGNGPRLCLLCLRFRATAFQREELMKMKVKDLRDYLSLHDISTEMCREKEELVFLVLGQQPVISEADRTRVPHLPQAFPEQQAFLTQPQTSTVPPTSPGLPSSPAQVTSVPLAQDQETQQAVGHVSQDHEEPIFPESTARVPTEDETQSVDSEDSFVPGRRASLSDLTHLEDIEGLTVRQLKEILARNFVNYKGCCEKWELMERVTRLYKDQKGLQHLVSGNEDQNGGAVPSGLEENLCKICMDSPIDCVLLECGHMVTCTKCGKRMNECPICRQYVIRAVHVFRS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15229288, ECO:0000269|PubMed:22609986}.
uniprot
proteins
mass_dalton
42249
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8WZ73}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000250}.; PTM: Palmitoylated. {ECO:0000250}.; PTM: Undergoes caspase-mediated cleavage upon death-receptor activation, by TNFSF10 for instance. May be mediated by the caspases CASP8 and CASP10 in a negative feedback loop (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
15229288
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19138581
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22609986
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15229288}. Cell membrane {ECO:0000269|PubMed:15229288}; Peripheral membrane protein {ECO:0000269|PubMed:15229288}. Recycling endosome membrane {ECO:0000305|PubMed:15229288}; Peripheral membrane protein {ECO:0000305|PubMed:15229288}. Note=The FYVE-type zinc finger may mediate phosphatidylinositol phosphate-binding and control subcellular localization.
uniprot
proteins