Siah1
entrez
140941
canonical
uniprot
Q920M9
canonical
ensembl
ENSRNOG00000015143
resolver
ensembl
ENSRNOG00055019541
resolver
ensembl
ENSRNOG00060014793
resolver
ensembl
ENSRNOG00065010264
resolver
ensp
ENSRNOP00000020329
resolver
ensp
ENSRNOP00000089183
resolver
ensp
ENSRNOP00000092688
resolver
ensp
ENSRNOP00000092754
resolver
ensp
ENSRNOP00000101118
resolver
ensp
ENSRNOP00000103855
resolver
ensp
ENSRNOP00000104306
resolver
ensp
ENSRNOP00000111435
resolver
ensp
ENSRNOP00055027060
resolver
ensp
ENSRNOP00055027066
resolver
ensp
ENSRNOP00055027071
resolver
ensp
ENSRNOP00055027076
resolver
ensp
ENSRNOP00055027079
resolver
ensp
ENSRNOP00060020137
resolver
ensp
ENSRNOP00060020143
resolver
ensp
ENSRNOP00060020147
resolver
ensp
ENSRNOP00060020149
resolver
ensp
ENSRNOP00060020153
resolver
ensp
ENSRNOP00065012616
resolver
ensp
ENSRNOP00065012620
resolver
ensp
ENSRNOP00065012626
resolver
ensp
ENSRNOP00065012628
resolver
ensp
ENSRNOP00065012633
resolver
enst
ENSRNOT00000020329
resolver
enst
ENSRNOT00000097354
resolver
enst
ENSRNOT00000111812
resolver
enst
ENSRNOT00000112896
resolver
enst
ENSRNOT00000155668
resolver
enst
ENSRNOT00000156871
resolver
enst
ENSRNOT00000167017
resolver
enst
ENSRNOT00000169540
resolver
enst
ENSRNOT00055033349
resolver
enst
ENSRNOT00055033357
resolver
enst
ENSRNOT00055033362
resolver
enst
ENSRNOT00055033367
resolver
enst
ENSRNOT00055033370
resolver
enst
ENSRNOT00060025277
resolver
enst
ENSRNOT00060025283
resolver
enst
ENSRNOT00060025287
resolver
enst
ENSRNOT00060025289
resolver
enst
ENSRNOT00060025293
resolver
enst
ENSRNOT00065016573
resolver
enst
ENSRNOT00065016577
resolver
enst
ENSRNOT00065016583
resolver
enst
ENSRNOT00065016585
resolver
enst
ENSRNOT00065016590
resolver
genesymbol
Siah1
resolver
genesymbol_syn
Siah1a
resolver
uniprot
A9UK92
resolver
uniprot
Q06984
resolver
uniprot_entry
A9UK92_RAT
resolver
uniprot_entry
SIAH1_RAT
resolver
uniprot_sec
Q06984
resolver
amino_acid_sequence
MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11786535, PubMed:15951807). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11786535, PubMed:15951807). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:11786535, PubMed:15951807). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), in transcriptional restart after DNA damage (AFF1), a cell surface receptor (DCC), cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP (PubMed:11786535). Confers constitutive instability to HIPK2 through proteasomal degradation (By similarity). It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription, spermatogenesis and TNF signaling (By similarity). Has some overlapping function with SIAH2 (By similarity). Induces apoptosis in cooperation with PEG3 (By similarity). Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus (PubMed:15951807). GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (PubMed:15951807). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1. {ECO:0000250|UniProtKB:P61092, ECO:0000250|UniProtKB:Q8IUQ4, ECO:0000269|PubMed:11786535, ECO:0000269|PubMed:15951807}.
uniprot
proteins
mass_dalton
31137
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:11786535, ECO:0000269|PubMed:15951807}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-19 by ATM and ATR. This phosphorylation disrupts SIAH1 interaction with HIPK2, and subsequent proteasomal degradation of HIPK2 (By similarity). {ECO:0000250|UniProtKB:Q8IUQ4}.
uniprot
proteins
protein_family
SINA (Seven in absentia) family
uniprot
proteins
pubmed
10469171
uniprot
proteins
pubmed
11786535
uniprot
proteins
pubmed
15064394
uniprot
proteins
pubmed
15951807
uniprot
proteins
pubmed
19224863
uniprot
proteins
pubmed
23403927
uniprot
proteins
sequence_length
282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
uniprot
proteins