Adra2b
entrez
24174
canonical
uniprot
P19328
canonical
ensembl
ENSRNOG00000013887
resolver
ensembl
ENSRNOG00055006213
resolver
ensembl
ENSRNOG00060019138
resolver
ensembl
ENSRNOG00065014694
resolver
ensp
ENSRNOP00000018584
resolver
ensp
ENSRNOP00055007814
resolver
ensp
ENSRNOP00060027077
resolver
ensp
ENSRNOP00065018967
resolver
enst
ENSRNOT00000018584
resolver
enst
ENSRNOT00055010090
resolver
enst
ENSRNOT00060033087
resolver
enst
ENSRNOT00065024286
resolver
genesymbol
Adra2b
resolver
uniprot
Q63021
resolver
uniprot
Q925E4
resolver
uniprot_entry
ADA2B_RAT
resolver
uniprot_sec
Q63021
resolver
uniprot_sec
Q925E4
resolver
amino_acid_sequence
MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
uniprot
proteins
function
FUNCTION: Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed:15213003, PubMed:2158103). ADRA2B physiological agonists includes norepinephrine (PubMed:2158103). {ECO:0000269|PubMed:15213003, ECO:0000269|PubMed:2158103}.
uniprot
proteins
mass_dalton
50369
uniprot
proteins
protein_family
ADRA2B sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15213003
uniprot
proteins
pubmed
15993847
uniprot
proteins
pubmed
2158103
uniprot
proteins
pubmed
7755946
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P18089}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18089}. Note=Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. {ECO:0000250|UniProtKB:P18089}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..40; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P18089"; TRANSMEM 54..79; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P18089"; TRANSMEM 91..113; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P18089"; TRANSMEM 135..153; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P18089"; TRANSMEM 176..198; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P18089"; TRANSMEM 376..396; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P18089"; TRANSMEM 411..431; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P18089
uniprot
proteins