Mapk4
entrez
225724
canonical
uniprot
Q6P5G0
canonical
ensembl
ENSMUSG00000024558
resolver
ensp
ENSMUSP00000089462
resolver
ensp
ENSMUSP00000160858
resolver
ensp
ENSMUSP00000160861
resolver
enst
ENSMUST00000091851
resolver
genesymbol
Mapk4
resolver
genesymbol_syn
Erk4
resolver
genesymbol_syn
Prkm4
resolver
uniprot_entry
MK04_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation at Ser-186.
uniprot
proteins
amino_acid_sequence
MAEKGDCIASVYGYDLGGRFIDFQPLGFGVNGLVLSATDSRACRKVAVKKIVLSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGSDLQGELFKFSVAYIVQEYMETDLACLLEQGTLTEDHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGKMLFAGAHELEQMQLILDTIPVVREEDKEELLRVMPSFVSSTWEVKRPLRKLLPDVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAASQSQLSNWDRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSTPLAEDVQVDPRKDSQSSSERFLEQSHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAASAPPRAAVAADPVSREDEPASLFLEIAQWVKSTQSGSERASPPPDAPEPRLSASPPGHPTPIDGGASPQFDLDVFISRALKLCTKPEDLPENKLGDLNGACISEHPGDLVQTEAFSKERW
uniprot
proteins
ec_number
2.7.11.24
uniprot
proteins
function
FUNCTION: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle. {ECO:0000269|PubMed:16973613}.
uniprot
proteins
mass_dalton
65574
uniprot
proteins
mutagenesis
MUTAGEN 49..50; /note="KK->AA: ATP-binding site mutant; unable to activate MAPKAPK5."; /evidence="ECO:0000269|PubMed:16973613"; MUTAGEN 168; /note="D->A: Kinase defective mutant, abolishes activity."; /evidence="ECO:0000269|PubMed:18248330"; MUTAGEN 186; /note="S->A,D: Unable to activate MAPKAPK5 promote MAPKAPK5 localization to the cytoplasm."; /evidence="ECO:0000269|PubMed:18248330, ECO:0000269|PubMed:18720373"; MUTAGEN 328; /note="F->A,Y: Impairs binding to MAPKAPK5."; /evidence="ECO:0000269|PubMed:19473979"; MUTAGEN 330; /note="I->K: Abolishes binding to MAPKAPK5."; /evidence="ECO:0000269|PubMed:19473979
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. {ECO:0000269|PubMed:18248330, ECO:0000269|PubMed:18720373}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MAP kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16973613
uniprot
proteins
pubmed
18248330
uniprot
proteins
pubmed
18720373
uniprot
proteins
pubmed
19473979
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
583
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16973613}. Nucleus {ECO:0000269|PubMed:16973613}. Note=Translocates to the cytoplasm following interaction with MAPKAPK5.
uniprot
proteins