Nek6
entrez
360161
canonical
uniprot
P59895
canonical
ensembl
ENSRNOG00000010897
resolver
ensembl
ENSRNOG00055009244
resolver
ensembl
ENSRNOG00060027406
resolver
ensembl
ENSRNOG00065027277
resolver
ensp
ENSRNOP00000083098
resolver
ensp
ENSRNOP00055012638
resolver
ensp
ENSRNOP00060039889
resolver
ensp
ENSRNOP00065038781
resolver
enst
ENSRNOT00000116855
resolver
enst
ENSRNOT00055015735
resolver
enst
ENSRNOT00060047945
resolver
enst
ENSRNOT00065047295
resolver
genesymbol
Nek6
resolver
uniprot
B1H218
resolver
uniprot_entry
B1H218_RAT
resolver
uniprot_entry
NEK6_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-108. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MAGQPSHMPHGGSPNHLCHVLGPAHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGIVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCIYPDPNHRPDIEYVHQVAKQMHVWTSST
uniprot
proteins
ec_number
2.7.11.34
uniprot
proteins
function
FUNCTION: Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIRSR, PTN, RAD26L, RBBP6, RPS7, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (By similarity). Phosphorylates RPS6KB1 (PubMed:11516946). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity). {ECO:0000250|UniProtKB:Q9HC98, ECO:0000269|PubMed:11516946}.
uniprot
proteins
mass_dalton
35835
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Phosphorylation at Ser-206 is required for its activation. Phosphorylated upon IR or UV-induced DNA damage. Phosphorylated by CHEK1 and CHEK2. Interaction with APBB1 down-regulates phosphorylation at Thr-210 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
NEK Ser/Thr protein kinase family
uniprot
proteins
protein_family
NIMA subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11516946
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Colocalizes with APBB1 at the nuclear speckles. Colocalizes with PIN1 in the nucleus. Colocalizes with ATF4, CIRSR, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis (By similarity). {ECO:0000250}.
uniprot
proteins