Atg7
entrez
74244
canonical
uniprot
Q9D906
canonical
ensembl
ENSMUSG00000030314
resolver
ensp
ENSMUSP00000032457
resolver
ensp
ENSMUSP00000133215
resolver
ensp
ENSMUSP00000138137
resolver
ensp
ENSMUSP00000138651
resolver
ensp
ENSMUSP00000201165
resolver
ensp
ENSMUSP00000201169
resolver
enst
ENSMUST00000032457
resolver
enst
ENSMUST00000169310
resolver
enst
ENSMUST00000182793
resolver
enst
ENSMUST00000182902
resolver
genesymbol
Atg7
resolver
genesymbol_syn
Apg7l
resolver
uniprot
A0A0A0MQN4
resolver
uniprot
Q3TCD9
resolver
uniprot
Q3TM87
resolver
uniprot
Q8K4Q5
resolver
uniprot_entry
A0A0A0MQN4_MOUSE
resolver
uniprot_entry
ATG7_MOUSE
resolver
uniprot_entry
Q3TM87_MOUSE
resolver
uniprot_sec
Q3TCD9
resolver
uniprot_sec
Q8K4Q5
resolver
amino_acid_sequence
MGDPGLAKLQFAPFNSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLPTRLTLEFSAFDMSASTPAHCCPAMGTLHNTNTLEAFKTADKKLLLEQSANEIWEAIKSGAALENPMLLNKFLLLTFADLKKYHFYYWFCCPALCLPESIPLIRGPVSLDQRLSPKQIQALEHAYDDLCRAEGVTALPYFLFKYDDDTVLVSLLKHYSDFFQGQRTKITVGVYDPCNLAQYPGWPLRNFLVLAAHRWSGSFQSVEVLCFRDRTMQGARDVTHSIIFEVKLPEMAFSPDCPKAVGWEKNQKGGMGPRMVNLSGCMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMGWGVRHVTFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAAERLQKIFPGVNARGFNMSIPMPGHPVNFSDVTMEQARRDVEQLEQLIDNHDVIFLLMDTRESRWLPTVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPSHLVAPADLGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEGGYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSPKVLDQYEREGFTFLAKVFNSSHSFLEDLTGLTLLHQETQAAEIWDMSDEETV
uniprot
proteins
function
FUNCTION: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes (By similarity). Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Also plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (PubMed:29937374). {ECO:0000250|UniProtKB:O95352, ECO:0000269|PubMed:11890701, ECO:0000269|PubMed:15131264, ECO:0000269|PubMed:15866887, ECO:0000269|PubMed:16704426, ECO:0000269|PubMed:17726112, ECO:0000269|PubMed:19417210, ECO:0000269|PubMed:19855132, ECO:0000269|PubMed:19910529, ECO:0000269|PubMed:20723759, ECO:0000269|PubMed:21339326, ECO:0000269|PubMed:21617129, ECO:0000269|PubMed:22291845, ECO:0000269|PubMed:22499945, ECO:0000269|PubMed:29937374}.
uniprot
proteins
mass_dalton
77520
uniprot
proteins
mutagenesis
MUTAGEN 567; /note="C->S: Instead of the formation of an intermediate complex with a thiol ester bond between ATG7 (E1-like enzyme) and GABARAPL1 (MAP1LC3, GABARAP or GABARAPL; substrates), a stable complex with an O-ester bond is formed."; /evidence="ECO:0000269|PubMed:11890701
uniprot
proteins
post_translational_modification
PTM: Acetylated by EP300. {ECO:0000250}.; PTM: Polyubiquitinated on Lys-41 via 'Lys-63'-linked ubiquitin by TRIM32; this modification positiely regulates ATG8 and ATG12 activating enzyme activity leading to initiation of autophagy under metabolic stress. {ECO:0000250|UniProtKB:O95352}.
uniprot
proteins
protein_family
ATG7 family
uniprot
proteins
pubmed
11890701
uniprot
proteins
pubmed
12482611
uniprot
proteins
pubmed
15131264
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15866887
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16704426
uniprot
proteins
pubmed
17726112
uniprot
proteins
pubmed
19417210
uniprot
proteins
pubmed
19855132
uniprot
proteins
pubmed
19910529
uniprot
proteins
pubmed
20723759
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21339326
uniprot
proteins
pubmed
21617129
uniprot
proteins
pubmed
22291845
uniprot
proteins
pubmed
22499945
uniprot
proteins
pubmed
24089209
uniprot
proteins
pubmed
29937374
uniprot
proteins
sequence_length
698
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Also localizes to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000269|PubMed:24089209}.
uniprot
proteins