CD274
entrez
29126
canonical
uniprot
Q9NZQ7
canonical
ensembl
ENSG00000120217
resolver
ensp
ENSP00000370985
resolver
ensp
ENSP00000370989
resolver
genesymbol
CD274
resolver
genesymbol_syn
B7H1
resolver
genesymbol_syn
PDCD1L1
resolver
genesymbol_syn
PDCD1LG1
resolver
genesymbol_syn
PDL1
resolver
hgnc
HGNC:17635
resolver
uniprot
B2RBA2
resolver
uniprot
B4DU27
resolver
uniprot
Q0GN75
resolver
uniprot
Q14CJ2
resolver
uniprot
Q2V8D5
resolver
uniprot
Q66RK1
resolver
uniprot
Q6WEX4
resolver
uniprot
Q9NUZ5
resolver
uniprot_entry
PD1L1_HUMAN
resolver
uniprot_entry
Q0GN75_HUMAN
resolver
uniprot_sec
B2RBA2
resolver
uniprot_sec
B4DU27
resolver
uniprot_sec
Q14CJ2
resolver
uniprot_sec
Q2V8D5
resolver
uniprot_sec
Q66RK1
resolver
uniprot_sec
Q6WEX4
resolver
uniprot_sec
Q9NUZ5
resolver
amino_acid_sequence
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
uniprot
proteins
disease_involvement
DISEASE: Autoimmune disease, multisystem, infantile-onset, 5 (ADMIO5) [MIM:621235]: An autosomal recessive disorder characterized by autoimmune manifestations apparent in the first months or years of life. ADMIO5 patients have complete insulin deficiency and type 1 diabetes mellitus with neonatal onset. {ECO:0000269|PubMed:38634869}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=Truncation of the 3'-untranslated (3'-UTR) region of CD274 transcripts leads to elevated expression of CD274 in multiple cancers including T-cell leukemia, diffuse large B-cell lymphoma and stomach adenocarcinoma (PubMed:27281199). Disruption of 3'-UTR region is caused by structural variants that stabilize CD274 transcripts, leading to overexpression (PubMed:27281199). Increased expression in tumors promotes immune evasion and tumor cell growth by allowing malignant cells to escape destruction by the immune system (PubMed:27281199). {ECO:0000269|PubMed:27281199}.
uniprot
proteins
function
FUNCTION: Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:36727298). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed:32929201). {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417, ECO:0000269|PubMed:31399419, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:36727298}.; FUNCTION: The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813410, PubMed:28813417). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity). {ECO:0000250|UniProtKB:Q9EP73, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}.
uniprot
proteins
mass_dalton
33275
uniprot
proteins
mutagenesis
MUTAGEN Q9NZQ7-4:238; /note="C->S: Largely abrogates multimerization, in vitro."; /evidence="ECO:0000269|PubMed:30564891
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation (PubMed:28813410). Ubiquitinated by MARCHF8; leading to degradation (PubMed:34183449). Deubiquitinated by USP22; leading to stabilization (PubMed:31399419). {ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:31399419, ECO:0000269|PubMed:34183449}.
uniprot
proteins
protein_family
BTN/MOG family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
10581077
uniprot
proteins
pubmed
11015443
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15780196
uniprot
proteins
pubmed
18287011
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
26602187
uniprot
proteins
pubmed
27281199
uniprot
proteins
pubmed
28813410
uniprot
proteins
pubmed
28813417
uniprot
proteins
pubmed
30564891
uniprot
proteins
pubmed
31399419
uniprot
proteins
pubmed
32929201
uniprot
proteins
pubmed
34183449
uniprot
proteins
pubmed
36232715
uniprot
proteins
pubmed
36727298
uniprot
proteins
pubmed
38634869
uniprot
proteins
sequence_length
290
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417, ECO:0000269|PubMed:36232715}; Single-pass type I membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:28813417}; Single-pass type I membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:28813417}; Single-pass type I membrane protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:32929201}. Note=Associates with CMTM6 at recycling endosomes, where it is protected from being targeted for lysosomal degradation (PubMed:28813417). Translocates to the nucleus in response to hypoxia via its interaction with phosphorylated STAT3 (PubMed:32929201). {ECO:0000269|PubMed:28813417, ECO:0000269|PubMed:32929201}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15780196}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Endomembrane system {ECO:0000269|PubMed:15780196}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000269|PubMed:30564891}.
uniprot
proteins
transmembrane_region
TRANSMEM 239..259; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins