Plekhg6
entrez
213522
canonical
uniprot
Q8R0J1
canonical
ensembl
ENSMUSG00000038167
resolver
ensp
ENSMUSP00000037004
resolver
enst
ENSMUST00000042647
resolver
genesymbol
Plekhg6
resolver
uniprot
E9QJZ0
resolver
uniprot_entry
PKHG6_MOUSE
resolver
uniprot_sec
E9QJZ0
resolver
amino_acid_sequence
MQAFGPPNEGPLQGLVASRIETYGGRHQTSAHSTAGNLFPRGGPGVDPSRRRLQHYVPFAKGSGQTRGMSPLVLREPDPEKRHGSYFGVGPPHSPKLKEVTRAHELEIRLHTFSMFGMPRLPPEDRRHWEIGEGGDSALTMEKSWKELVLEHKEMNRQLCHQQEALWELLTTELIYLRKLKIMTDLLAAGLLNLQRVGLLTEVSAETLFGNVPNLIRAHRRFWEEVLQPILEDTRTSGQPLDPVSLQNGFLTFGQRFQPYVQYCLRVKQTMAYAREQQDTNPLFHTFVQWCEKHKRSGRQTLGDLLIKPHQRITKYPLLLQAVRKRSPEPRAQEALNAMIEAVESFLRHINGQVRQGEEQESLMAVAQRIGPYEVLEPSSEEVEKNLRPFSTLDLMTPVLGVAPEYTRQLLLEGPVRVKEGREGKMDVYLFLFSDVLLVTKPQRKADRAKVIRPPLMLEKLVCRPLRDPNSFLLIHLTEFQCVSSALTVHCPSSTERARWLEKTQHAQTTLQKLKGEQYIQQKRELLALYRNQGTESPSTRPSTPSPSPEDSQSSAEGRTLEFAIIPRLVVTEDTDEDTPSMPDDASDSGYGTLIPSSPKDSHSPLNRLRSKALRRDPRLTFSTLELRDVPLRPQPPDPQAPQRRSAPELPEGILRGGSLPRRAPPIWSEEEDETLASGNVVVETLHRAQRRSPLPHSPTHTDSAGESPWESSDEDEGLLSPELRPRSLREDMLREIREELANQRIDGASEPEPGNGKPRRLTLAQLQRMRVPHIIQLDTPLSTSEV
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
89148
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
787
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, microvillus {ECO:0000250|UniProtKB:Q3KR16}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q3KR16}. Cleavage furrow {ECO:0000250|UniProtKB:Q3KR16}. Note=During mitosis, localizes to the spindle pole, central spindle and cleavage furrow. In epithelial cells, recruited to the apical membrane by EZR where it participates in macropinocytosis. {ECO:0000250|UniProtKB:Q3KR16}.
uniprot
proteins