Camk2a
entrez
12322
canonical
uniprot
P11798
canonical
ensembl
ENSMUSG00000024617
resolver
ensp
ENSMUSP00000025519
resolver
ensp
ENSMUSP00000048325
resolver
ensp
ENSMUSP00000099952
resolver
ensp
ENSMUSP00000110950
resolver
enst
ENSMUST00000025519
resolver
enst
ENSMUST00000039904
resolver
genesymbol
Camk2a
resolver
uniprot
F8WHB5
resolver
uniprot
F8WIS9
resolver
uniprot
Q61284
resolver
uniprot
Q6ZWN4
resolver
uniprot_entry
F8WHB5_MOUSE
resolver
uniprot_entry
F8WIS9_MOUSE
resolver
uniprot_entry
KCC2A_MOUSE
resolver
uniprot_sec
Q61284
resolver
uniprot_sec
Q6ZWN4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-286 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity. {ECO:0000250|UniProtKB:Q9UQM7}.
uniprot
proteins
amino_acid_sequence
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (By similarity). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (By similarity). Also regulates the migration of developing neurons (By similarity). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (PubMed:15994560). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of PSAT1, inhibiting ferroptosis by promoting GPX4 hydroxylation and stability (By similarity). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (PubMed:23502535). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:Q9UQM7, ECO:0000269|PubMed:15994560, ECO:0000269|PubMed:23502535, ECO:0000269|PubMed:23805378}.; FUNCTION: [Isoform Alpha KAP]: Has no kinase activity. {ECO:0000269|PubMed:8524307}.
uniprot
proteins
mass_dalton
54115
uniprot
proteins
mutagenesis
MUTAGEN 183; /note="E->V: Decreased protein abundance. Decreased autophosphorylation. Changed subcellular localization. Homozygous mice for that mutation are hyperactive and display repetitive behaviors. They also display social deficits and decreased exploratory behavior."; /evidence="ECO:0000269|PubMed:28130356"; MUTAGEN 286; /note="T->A: Abolishes autophosphorylation. Loss of FOXO3 activation. Reduces association with DAGLA. Enhances DAGLA enzymatic activity with an increase of 2-AG levels in dorsolateral striatal tissue of knockin mice. Inhibition of 2-AG breakdown using JZL-184 decreased locomotor activity in knockin mice."; /evidence="ECO:0000269|PubMed:23502535, ECO:0000269|PubMed:23805378"; MUTAGEN 286; /note="T->D: Phosphomimetic mutant. Enhanced FOXO3 activation."; /evidence="ECO:0000269|PubMed:23805378
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation of Thr-286 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-286 locks the kinase into an activated state. {ECO:0000269|PubMed:28130356}.; PTM: Palmitoylated. Probably palmitoylated by ZDHHC3 and ZDHHC7. {ECO:0000250|UniProtKB:P11275}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15994560
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23502535
uniprot
proteins
pubmed
23805378
uniprot
proteins
pubmed
2543961
uniprot
proteins
pubmed
28130356
uniprot
proteins
pubmed
28642476
uniprot
proteins
pubmed
8524307
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Alpha KAP]: Cytoplasm {ECO:0000305|PubMed:8524307}.; SUBCELLULAR LOCATION: Synapse {ECO:0000269|PubMed:28642476}. Postsynaptic density {ECO:0000250|UniProtKB:P11275}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9UQM7}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9UQM7}. Note=Postsynaptic lipid rafts. {ECO:0000250|UniProtKB:P11275}.
uniprot
proteins