Gpr15lg
entrez
70045
canonical
uniprot
A0A0B4J1N3
canonical
ensembl
ENSMUSG00000096001
resolver
ensp
ENSMUSP00000136426
resolver
enst
ENSMUST00000179488
resolver
genesymbol
Gpr15lg
resolver
genesymbol_syn
Gpr15l
resolver
uniprot_entry
GP15L_MOUSE
resolver
amino_acid_sequence
MRLLALSGLLCMLLLCFCIFSSEGRRHPAKSLKLRRCCHLSPRSKLTTWKGNHTRPCRLCRNKLPVKSWVVPGALPQI
uniprot
proteins
function
FUNCTION: Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G protein-coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (By similarity). May regulate keratinocyte proliferation. In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (PubMed:35704588). {ECO:0000250|UniProtKB:Q6UWK7, ECO:0000269|PubMed:28900043, ECO:0000269|PubMed:28936214, ECO:0000269|PubMed:35704588}.; FUNCTION: Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus. {ECO:0000250|UniProtKB:Q6UWK7}.
uniprot
proteins
mass_dalton
8899
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
28900043
uniprot
proteins
pubmed
28936214
uniprot
proteins
pubmed
29872130
uniprot
proteins
pubmed
35704588
uniprot
proteins
sequence_length
78
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6UWK7}.
uniprot
proteins