Panx3
entrez
208098
canonical
uniprot
Q8CEG0
canonical
ensembl
ENSMUSG00000011118
resolver
ensp
ENSMUSP00000011262
resolver
enst
ENSMUST00000011262
resolver
genesymbol
Panx3
resolver
genesymbol_syn
Panx
resolver
uniprot
Q6IMP0
resolver
uniprot
Q8CB28
resolver
uniprot_entry
PANX3_MOUSE
resolver
uniprot_entry
Q6IMP0_MOUSE
resolver
uniprot_sec
Q8CB28
resolver
amino_acid_sequence
MSLAHTAAEYMLSDALLPDRRGSRLKGLRLELPLDKMVKFITVGFPLLLMSLAFAQEFSSGSPISCFSPSNFSVRQAAYVDSSCWDSLAHHTQDKAGQYKVKSLWPHKALPYSLLALAVAMYLPVLLWQYVAVPSLSSDLLFIISELDKSYNRSIRLVQHMLQIRQSSSDPHVFWDELEKARKERYFEFPLLERYLECKQRSHWLVATYLLRNALLLLFTSATYLYLGQFHLDVFFQDEFNCFIKTGLLHDETHVPELITCRLTSLSVFQIVSVSSAAIYTILVPVIIYNLTRLCRWDKGLLSIYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSVLSVLKDTTTQKHNIDTVVDFMTFVAGLEPSKPKHLTQHTYDEHA
uniprot
proteins
function
FUNCTION: Regulator of osteoblast differentiation by functioning as a Ca(2+) channel in the endoplasmic reticulum which regulates calmodulin (CaM) pathways. Allows ATP release into the extracellular space and activation or purinergic receptors. {ECO:0000269|PubMed:21690309}.
uniprot
proteins
mass_dalton
44928
uniprot
proteins
mutagenesis
MUTAGEN 71; /note="N->Q: Impairs glycosylation."; /evidence="ECO:0000269|PubMed:17925379
uniprot
proteins
post_translational_modification
PTM: N-glycosylation may play a role in cell surface targeting. {ECO:0000269|PubMed:17925379}.
uniprot
proteins
protein_family
Pannexin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17925379
uniprot
proteins
pubmed
21690309
uniprot
proteins
sequence_length
392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21690309}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21690309}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"; TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"; TRANSMEM 216..236; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"; TRANSMEM 268..288; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351
uniprot
proteins