Arl6ip5
entrez
65106
canonical
uniprot
Q8R5J9
canonical
ensembl
ENSMUSG00000035199
resolver
ensp
ENSMUSP00000041503
resolver
enst
ENSMUST00000044681
resolver
genesymbol
Arl6ip5
resolver
genesymbol_syn
Aip5
resolver
genesymbol_syn
Jwa
resolver
genesymbol_syn
Pra2
resolver
genesymbol_syn
Praf3
resolver
uniprot
Q8C2Q1
resolver
uniprot
Q9D838
resolver
uniprot
Q9DB37
resolver
uniprot
Q9WUG9
resolver
uniprot_entry
PRAF3_MOUSE
resolver
uniprot_sec
Q8C2Q1
resolver
uniprot_sec
Q9D838
resolver
uniprot_sec
Q9DB37
resolver
uniprot_sec
Q9WUG9
resolver
amino_acid_sequence
MDVNLAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISVVGFLSPFNMILGGVIVVLVFMGFVWAAHNKDILRRMKKQYPTAFVMVVMLASYFLISMFGGVMVFVFGITLPLLLMFIHASLRLRNLKNKLENKMEGIGLKKTPMGIILDALEQQEDNINKFADYISKARE
uniprot
proteins
function
FUNCTION: Regulates intracellular concentrations of taurine and glutamate (By similarity). Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner (PubMed:12119102, PubMed:18684713). Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q9ES40, ECO:0000269|PubMed:12119102, ECO:0000269|PubMed:18684713}.
uniprot
proteins
mass_dalton
21558
uniprot
proteins
mutagenesis
MUTAGEN 110; /note="Y->A: Significant decrease in interaction with ARL6IP1 and no influence on SLC1A1/EAAC1-mediated glutamate transport; when associated with A-112."; /evidence="ECO:0000269|PubMed:18684713"; MUTAGEN 112; /note="L->A: Significant decrease in interaction with ARL6IP1 and no influence on SLC1A1/EAAC1-mediated glutamate transport; when associated with A-110."; /evidence="ECO:0000269|PubMed:18684713
uniprot
proteins
protein_family
PRA1 family
uniprot
proteins
pubmed
10508919
uniprot
proteins
pubmed
12119102
uniprot
proteins
pubmed
12438930
uniprot
proteins
pubmed
12562531
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18684713
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
188
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12438930}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9ES40}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:12438930}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12438930}. Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules. {ECO:0000269|PubMed:12438930}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 64..84; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins