DNAJB12
entrez
54788
canonical
uniprot
Q9NXW2
canonical
ensembl
ENSG00000148719
resolver
ensp
ENSP00000345575
resolver
ensp
ENSP00000378363
resolver
ensp
ENSP00000403313
resolver
ensp
ENSP00000546825
resolver
ensp
ENSP00000649271
resolver
enst
ENST00000338820
resolver
enst
ENST00000394903
resolver
genesymbol
DNAJB12
resolver
hgnc
HGNC:14891
resolver
uniprot
B7Z7I3
resolver
uniprot
J3KPS0
resolver
uniprot
Q9H6H0
resolver
uniprot_entry
DJB12_HUMAN
resolver
uniprot_entry
J3KPS0_HUMAN
resolver
uniprot_sec
B7Z7I3
resolver
uniprot_sec
Q9H6H0
resolver
amino_acid_sequence
MESNKDEAERCISIALKAIQSNQPDRALRFLEKAQRLYPTPRVRALIESLNQKPQTAGDQPPPTDTTHATHRKAGGTDAPSANGEAGGESTKGYTAEQVAAVKRVKQCKDYYEILGVSRGASDEDLKKAYRRLALKFHPDKNHAPGATEAFKAIGTAYAVLSNPEKRKQYDQFGDDKSQAARHGHGHGDFHRGFEADISPEDLFNMFFGGGFPSSNVHVYSNGRMRYTYQQRQDRRDNQGDGGLGVFVQLMPILILILVSALSQLMVSSPPYSLSPRPSVGHIHRRVTDHLGVVYYVGDTFSEEYTGSSLKTVERNVEDDYIANLRNNCWKEKQQKEGLLYRARYFGDTDMYHRAQKMGTPSCSRLSEVQASLHG
uniprot
proteins
function
FUNCTION: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:21148293, PubMed:21150129). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:21148293). Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). {ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744). {ECO:0000269|PubMed:21673190, ECO:0000269|PubMed:24675744}.
uniprot
proteins
mass_dalton
41860
uniprot
proteins
mutagenesis
MUTAGEN 138; /note="H->Q: Abolishes interaction with HSPA8/Hsc70."; /evidence="ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:24732912"; MUTAGEN 184..212; /note="Missing: In delta(G/F); impaired ability to form tetramers and impaired ability to promote potassium channel assembly into tetramers."; /evidence="ECO:0000269|PubMed:27916661"; MUTAGEN 185; /note="H->R: Abolished histidine methylation by METTL9."; /evidence="ECO:0000269|PubMed:33563959
uniprot
proteins
post_translational_modification
PTM: Methylated at His-185 by METTL9. {ECO:0000305|PubMed:33563959}.
uniprot
proteins
protein_family
DNAJB12/DNAJB14 subfamily
uniprot
proteins
protein_family
DnaJ family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21148293
uniprot
proteins
pubmed
21150129
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21673190
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24675744
uniprot
proteins
pubmed
24732912
uniprot
proteins
pubmed
25631089
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27916661
uniprot
proteins
pubmed
33563959
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000269|PubMed:24732912}; Single-pass membrane protein {ECO:0000305}. Note=Localizes to the endoplasmic reticulum membrane (PubMed:21148293, PubMed:21150129, PubMed:24732912, PubMed:27916661). When overexpressed, forms membranous structures in the nucleus (PubMed:24732912). {ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; SUBCELLULAR LOCATION: Note=(Microbial infection) Upon SV40 infection, colocalizes with BCAP31, DNAJC18 and DNAJB14 in punctate structures within the endoplasmic reticulum membrane. {ECO:0000269|PubMed:25631089}.
uniprot
proteins
transmembrane_region
TRANSMEM 244..264; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins