Sigirr
entrez
309106
canonical
uniprot
Q4V892
canonical
ensembl
ENSRNOG00000015593
resolver
ensembl
ENSRNOG00055029016
resolver
ensembl
ENSRNOG00060027860
resolver
ensembl
ENSRNOG00065018942
resolver
ensp
ENSRNOP00000051758
resolver
ensp
ENSRNOP00055041385
resolver
ensp
ENSRNOP00060040402
resolver
ensp
ENSRNOP00065025423
resolver
enst
ENSRNOT00055050296
resolver
enst
ENSRNOT00060048487
resolver
enst
ENSRNOT00065031865
resolver
genesymbol
Sigirr
resolver
uniprot_entry
SIGIR_RAT
resolver
amino_acid_sequence
MAGVCDRVPNFLSPSEDQALGPALGSAVALNCTAWVFSRPQCPQPSVQWLKDGLALGNGSHFSLHQDFWVSDNFSEIVSSVLVFNLTKAEDYGTFTCSAWNVSSHSFTLWRAGPAGHVAAVLASLLVLVVLLLVALLYVKCRLNVLLWYQDTYGEVEMNDGKLYDAYVSYSDRPEDRKFVNFILKPQLERRRGYKLFLEDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLRRPWCSQSFREGLCRLLELTRRPIFITFEGQRREPIHPALRLLRQHRHLVTLLLWKPGSVTPSSDFWKELQLALPRKVQYRPVEGDPQTRLQDDKDPMLIVRGRAAQGRAMESELDPDPEGDLGVRGPVFGEPPTPLHESKVSIGEGHASEMDVSDLGSRNYSARTDFYCLVSEDDV
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
46171
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
409
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 119..139; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins