Capn1
entrez
12333
canonical
uniprot
O35350
canonical
ensembl
ENSMUSG00000024942
resolver
ensp
ENSMUSP00000025891
resolver
ensp
ENSMUSP00000127498
resolver
enst
ENSMUST00000025891
resolver
enst
ENSMUST00000164843
resolver
genesymbol
Capn1
resolver
genesymbol_syn
Canp1
resolver
genesymbol_syn
Capa1
resolver
uniprot
O88666
resolver
uniprot
Q3TB79
resolver
uniprot
Q3TI07
resolver
uniprot
Q3UF24
resolver
uniprot_entry
CAN1_MOUSE
resolver
uniprot_entry
Q3TB79_MOUSE
resolver
uniprot_entry
Q3TI07_MOUSE
resolver
uniprot_entry
Q3UF24_MOUSE
resolver
uniprot_sec
O88666
resolver
activity_regulation
ACTIVITY REGULATION: Activated by micromolar concentrations of calcium and inhibited by calpastatin. {ECO:0000250|UniProtKB:P07384}.
uniprot
proteins
amino_acid_sequence
MTEELITPVYCTGVSAQVQKKRDKELGLGRHENAIKYLGQDYETLRARCLQSGVLFQDEAFPPVSHSLGFKELGPHSSKTYGIKWKRPTELMSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQDGYAGIFHFQLWQFGEWVDVVIDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGHAYSVTGAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSDSSYEWNKVDPYEREQLRVKMEDGEFWMSFRDFIREFTKLEICNLTPDALKSRTLRNWNTTFYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEEVDDADDYDNRESGCSFLLALMQKHRRRERRFGRDMETIGFAVYQVPRELAGQPVHLKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRFFSEKKAGTQELDDQIQANLPDEKVLSEEEIDDNFKTLFSKLAGDDMEISVKELQTILNRIISKHKDLRTNGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFRKFDLDKSGSMSAYEMRMAIEAAGFKLNKKLHELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKLLDTDLDGVVTFDLFKWLQLTMFA
uniprot
proteins
ec_number
3.4.22.52
uniprot
proteins
function
FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-388' and 'His-410'. Cleaves and activates caspase-7 (CASP7). {ECO:0000250|UniProtKB:P07384}.
uniprot
proteins
mass_dalton
82106
uniprot
proteins
post_translational_modification
PTM: Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms (By similarity). {ECO:0000250|UniProtKB:P07384}.; PTM: Ubiquitinated via 'Lys6'-, 'Lys27'-, 'Lys29'-, and 'Lys63'-linked chains by the E3 ubiquitin ligase complex at least composed of CUL3, KCTD7 and RBX1 to execute atypical, non-degradative ubiquitination. {ECO:0000250|UniProtKB:P07384}.
uniprot
proteins
protein_family
Peptidase C2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
713
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P07384}. Cell membrane {ECO:0000250|UniProtKB:P07384}. Note=Translocates to the plasma membrane upon Ca(2+) binding. {ECO:0000250|UniProtKB:P07384}.
uniprot
proteins