Osbpl3
entrez
71720
canonical
uniprot
Q9DBS9
canonical
ensembl
ENSMUSG00000029822
resolver
ensp
ENSMUSP00000071643
resolver
ensp
ENSMUSP00000087473
resolver
ensp
ENSMUSP00000110110
resolver
ensp
ENSMUSP00000110112
resolver
ensp
ENSMUSP00000278904
resolver
ensp
ENSMUSP00000278905
resolver
ensp
ENSMUSP00000278915
resolver
enst
ENSMUST00000071728
resolver
enst
ENSMUST00000090019
resolver
enst
ENSMUST00000114466
resolver
enst
ENSMUST00000114468
resolver
genesymbol
Osbpl3
resolver
genesymbol_syn
Orp3
resolver
uniprot
D3YTT6
resolver
uniprot
D3Z194
resolver
uniprot
E9QNI5
resolver
uniprot
F8WH20
resolver
uniprot_entry
D3YTT6_MOUSE
resolver
uniprot_entry
D3Z194_MOUSE
resolver
uniprot_entry
F8WH20_MOUSE
resolver
uniprot_entry
OSBL3_MOUSE
resolver
uniprot_sec
E9QNI5
resolver
amino_acid_sequence
MSDEKNLGVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGEMTYTQEPPVQKGFLLKKRKWPLKGWHKRFFCLEKGILKYAKSQADIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKSEELFDEWVSKLRHHRMYRQNEIAMFPRDVNHFFSGSSVTDSAPGVFESVSSRKRSSLSKQNSFPPGSNLSFSCGGDTRVPFWLQSSEDMEKCSKDMAHCHAYLLEMSQLLESMDVLHRTYSAPAINAIQVPKPFSGPVRLHSSNPNLSTLDFGEEKSYSDGSEASSEFSKMQEDLCHVAHKVYFALRSAFNSISVEREKLKQLMELDTSPSPSAQVVGLKHALSSALAQNTDLKERLRRIHAESLLLDPPAVPKPGDNLAEENSRDEGRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSYVSDISDNLSLDNLSNDLDNERQTLGPVLESSGEARSKRRTSLPAPGPNTSSVSLWSILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKASRIPSPLERMVYVAAFAISAYASSYFRAGSKPFNPVLGETYECIRQDKGFQFFAEQVSHHPPISACHAESGNFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPAFGDHFEWNKVTSCIHNILSGQRWIEHYGEIDIKNLNDDSCHCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESIYCGGASSSTCVWRANPMPKGYEQYYGFTQFALELNEMDPLSRSLLPPTDTRFRPDQRLLEEGNIEEAEVQKQRIEKLQRERRRVLEENGVEHQPRFFRKSSDDAWVSNGTYLELRKDLGFSKLDHPVLW
uniprot
proteins
function
FUNCTION: Lipid transfer protein that mediates the non-vesicular transport of phosphoinositide 4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), or PI(4)P) at the plasma membrane (PM)/ endoplasmic reticulum (ER) contact sites. Extracts PI4P from the PM, in exchange for phosphatidylcholine. Can bind to the ER membrane protein VAPA and recruit VAPA to PM sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol. {ECO:0000250|UniProtKB:Q9H4L5}.
uniprot
proteins
mass_dalton
96966
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is enhanced in vitro by phorbol-12-myristate-13-acetate (PMA), forskolin and calcium ionophore A23187. Phosphorylation seems to be stimulated in conditions of low cell-cell (or cell-matrix) adhesion. {ECO:0000250|UniProtKB:Q9H4L5}.
uniprot
proteins
protein_family
OSBP family
uniprot
proteins
pubmed
14593528
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30028970
uniprot
proteins
sequence_length
855
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30028970}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:30028970}. Cell membrane {ECO:0000269|PubMed:30028970}; Peripheral membrane protein {ECO:0000305}. Cell projection, filopodium tip {ECO:0000250|UniProtKB:Q9H4L5}. Nucleus membrane {ECO:0000250|UniProtKB:Q9H4L5}; Peripheral membrane protein {ECO:0000305}. Note=Co-localizes with OSBPL6 at contact sites between the plasma membrane and the endoplasmic reticulum. {ECO:0000269|PubMed:30028970}.
uniprot
proteins