Itpripl1
entrez
499885
canonical
uniprot
Q66H52
canonical
ensembl
ENSRNOG00000012151
resolver
ensembl
ENSRNOG00055005299
resolver
ensembl
ENSRNOG00060014637
resolver
ensembl
ENSRNOG00065012896
resolver
ensp
ENSRNOP00000077758
resolver
ensp
ENSRNOP00000079259
resolver
ensp
ENSRNOP00000099379
resolver
ensp
ENSRNOP00000103836
resolver
ensp
ENSRNOP00055006463
resolver
ensp
ENSRNOP00055006466
resolver
ensp
ENSRNOP00060019918
resolver
ensp
ENSRNOP00060019923
resolver
ensp
ENSRNOP00065016263
resolver
ensp
ENSRNOP00065016265
resolver
enst
ENSRNOT00000110996
resolver
enst
ENSRNOT00000113642
resolver
enst
ENSRNOT00000150198
resolver
enst
ENSRNOT00000154461
resolver
enst
ENSRNOT00055008514
resolver
enst
ENSRNOT00055008517
resolver
enst
ENSRNOT00060024997
resolver
enst
ENSRNOT00060025007
resolver
enst
ENSRNOT00065021080
resolver
enst
ENSRNOT00065021083
resolver
genesymbol
Itpripl1
resolver
uniprot
A0ABK0L9Y1
resolver
uniprot_entry
A0ABK0L9Y1_RAT
resolver
uniprot_entry
IPIL1_RAT
resolver
amino_acid_sequence
MAVISLLFLAVMYVVHHPLMVSDRMDLDTLARSRQLEKRMSEEMRQLEIEFEERSRAAEEKQKAENFWRGDTSNDQLVLGKKDMRWPFQASGQDGGPLGWMLGNLWNAGLFCLFLIFELLRQNMQHEPAFESSSEEEEEEIRVVPVSSYTWLSGFPSQEALESFYKHYIQNAIRDLPCTCEFVESFVDDLIEACRVLSRREAHPQLEDCLGIGAAFEKWGTLHETQKFDVLVPIVPPQGTMFILEMRDPTLGRRCGCVKVDSECVCKNEKLLGDVLCLVHHRDHSAMLSKCTSSIKAALCTSSHLDVYKTVQWFRNMVSNAWALVAHKYDFKLTLPPSTTTCKLRLDYRSGRSLSISLVLGVQREDTLVYLVSQAPEREQFTSVDWPESFAACEHLFLKLVGRFAPDNTCHLKCLQIILSLQDHQTLPPGASRPILTSYHFKTALMHLLLRLPLTDWQHRMLSQRLQDLLWFLGRSLQQRSLHHFLIGNTHLPLTIPIPKAFRNAEPVNLFQHLVLNPVAHSQAVEEFHNLLAQVKTLPCSPLAGGL
uniprot
proteins
function
FUNCTION: Functions as a ligand of CD3E, inhibiting TCR-CD3 complex signaling to regulate T cell activation. Induces stable CD3E-NCK1 binding, thereby preventing the CD3E-ZAP70 interaction and subsequently inhibiting the activation of the downstream ERK-NFkB signaling cascade and calcium influx. {ECO:0000250|UniProtKB:Q6GPH6}.
uniprot
proteins
mass_dalton
62548
uniprot
proteins
protein_family
ITPRIP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6GPH6}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 97..117; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins