Sinhcaf
entrez
56306
canonical
uniprot
Q8C8M1
canonical
ensembl
ENSMUSG00000039985
resolver
ensp
ENSMUSP00000050952
resolver
ensp
ENSMUSP00000107187
resolver
ensp
ENSMUSP00000107188
resolver
ensp
ENSMUSP00000145487
resolver
ensp
ENSMUSP00000341754
resolver
enst
ENSMUST00000054080
resolver
enst
ENSMUST00000081956
resolver
enst
ENSMUST00000111562
resolver
enst
ENSMUST00000204435
resolver
genesymbol
Sinhcaf
resolver
genesymbol_syn
Fam60a
resolver
genesymbol_syn
Tera
resolver
uniprot
P70361
resolver
uniprot
Q3TLD2
resolver
uniprot_entry
SHCAF_MOUSE
resolver
uniprot_sec
P70361
resolver
uniprot_sec
Q3TLD2
resolver
amino_acid_sequence
MFGFHKPKMYRSIEGCCICRAKSSSSRFTDSKRYEKDFQSCFGLHETRSGDICNACVLLVKRWKKLPAGSKKNWNHVVDARAGPSLKTTLKPKKVKTLSGNRMKSNQISKLQKEFKRHNSDAHSTTSSASPAQSPCYSNQSDEGSDTEMASSSNRTPVFSFLDLTYWKRQKICCGIIYKGRFGEVLIDTHLFKPCCSSKKAAAEKPEEQGPAPLPISTQEW
uniprot
proteins
function
FUNCTION: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (By similarity). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (PubMed:28554894). {ECO:0000250|UniProtKB:Q9NP50, ECO:0000269|PubMed:28554894}.
uniprot
proteins
mass_dalton
24829
uniprot
proteins
protein_family
SINHCAF family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28554894
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28554894}.
uniprot
proteins