Grm5
entrez
24418
canonical
uniprot
P31424
canonical
ensembl
ENSRNOG00000016429
resolver
ensembl
ENSRNOG00055019318
resolver
ensembl
ENSRNOG00060020535
resolver
ensembl
ENSRNOG00065028675
resolver
ensp
ENSRNOP00000022059
resolver
ensp
ENSRNOP00000040016
resolver
ensp
ENSRNOP00000106840
resolver
genesymbol
Grm5
resolver
genesymbol_syn
Gprc1e
resolver
genesymbol_syn
Mglur5
resolver
uniprot
B2CZC8
resolver
uniprot_entry
B2CZC8_RAT
resolver
uniprot_entry
GRM5_RAT
resolver
amino_acid_sequence
MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLRSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLRNPWFQEFWQHRFQCRLEGFAQENSKYNKTCNSSLTLRTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLDSLMKTNFTGVSGDMILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKNNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVIFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSTRGQHLWQRLSVHINKKENPNQTAVIKPFPKSTENRGPGAAAGGGSGPGVAGAGNAGCTATGGPEPPDAGPKALYDVAEAEESFPAAARPRSPSPISTLSHLAGSAGRTDDDAPSLHSETAARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAATPGPPGTPICSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQGATGVSPAQETPTGAESAPGKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. {ECO:0000269|PubMed:1320017, ECO:0000269|PubMed:21795692}.
uniprot
proteins
mass_dalton
131885
uniprot
proteins
mutagenesis
MUTAGEN 1154; /note="L->V: Normal binding to HOMER1."; /evidence="ECO:0000269|PubMed:9808459"; MUTAGEN 1156; /note="P->K: Disrupts binding to HOMER1."; /evidence="ECO:0000269|PubMed:9808459"; MUTAGEN 1157; /note="P->E: Disrupts binding to HOMER1."; /evidence="ECO:0000269|PubMed:9808459"; MUTAGEN 1157; /note="P->L: Disrupts binding to HOMER1."; /evidence="ECO:0000269|PubMed:9808459"; MUTAGEN 1158; /note="S->F: Normal binding to HOMER1."; /evidence="ECO:0000269|PubMed:9808459"; MUTAGEN 1159; /note="P->A: Normal binding to HOMER1."; /evidence="ECO:0000269|PubMed:9808459"; MUTAGEN 1160; /note="F->R: Disrupts binding to HOMER1."; MUTAGEN 1161; /note="R->T: Normal binding to HOMER1."; /evidence="ECO:0000269|PubMed:9808459
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
pubmed
10469171
uniprot
proteins
pubmed
10798399
uniprot
proteins
pubmed
11850456
uniprot
proteins
pubmed
1320017
uniprot
proteins
pubmed
19694902
uniprot
proteins
pubmed
20007903
uniprot
proteins
pubmed
21795692
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7688218
uniprot
proteins
pubmed
9808459
uniprot
proteins
sequence_length
1203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1320017}; Multi-pass membrane protein {ECO:0000269|PubMed:1320017}.
uniprot
proteins
transmembrane_region
TRANSMEM 580..602; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 613..635; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 644..666; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 693..713; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 737..758; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 772..794; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 798..819; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins