ITPRIPL1
entrez
150771
canonical
uniprot
Q6GPH6
canonical
ensembl
ENSG00000198885
resolver
ensp
ENSP00000355121
resolver
ensp
ENSP00000389308
resolver
ensp
ENSP00000439566
resolver
ensp
ENSP00000558364
resolver
genesymbol
ITPRIPL1
resolver
genesymbol_syn
KIAA1754L
resolver
hgnc
HGNC:29371
resolver
uniprot
F5H1L8
resolver
uniprot
Q8NE61
resolver
uniprot_entry
IPIL1_HUMAN
resolver
uniprot_sec
F5H1L8
resolver
uniprot_sec
Q8NE61
resolver
amino_acid_sequence
MNVDAEASMAVISLLFLAVMYVVHHPLMVSDRMDLDTLARSRQLEKRMSEEMRLLEMEFEERKRAAEQRQKAENFWTGDTSSDQLVLGKKDMGWPFQADGQEGPLGWMLGNLWNTGLFCLFLVFELLRQNMQHEPAFDSSSEEEEEEVRVVPVTSYNWLTDFPSQEALDSFYKHYVQNAIRDLPCTCEFVESFVDDLIEACRVLSRQEAHPQLEDCLGIGAAFEKWGTLHETQKFDILVPIVPPQGTMFVLEMRDPALGRRCGCVLVESECVCKREKLLGDVLCLVHHHRDPSAVLGKCSSSIKAALCTGFHLDVCKTVQWFRNMMGNAWALVAHKYDFKLSLPPSTTSCKLRLDYRSGRFLSIHLVLGVQREDTLVYLVSQAPDQEQLTSVDWPESFVACEHLFLKLVGRFAPENTCHLKCLQIILSLRQHQSLPHGASRPILTSYHFKTALMHLLLRLPLTDWAHNMLSQRLQDILWFLGRGLQQRSLHHFLIGNNFLPLTIPIPKTFRNAEPVNLFQHLVLNPKAHSQAVEEFQNLLTQVKTLPHAPLAAAP
uniprot
proteins
function
FUNCTION: Functions as a ligand of CD3E, inhibiting TCR-CD3 complex signaling to regulate T cell activation. Induces stable CD3E-NCK1 binding, thereby preventing the CD3E-ZAP70 interaction and subsequently inhibiting the activation of the downstream ERK-NFkB signaling cascade and calcium influx. {ECO:0000269|PubMed:38614099}.
uniprot
proteins
mass_dalton
63395
uniprot
proteins
protein_family
ITPRIP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
38614099
uniprot
proteins
sequence_length
555
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:38614099}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins