SLCO4A1
entrez
28231
canonical
uniprot
Q96BD0
canonical
ensembl
ENSG00000101187
resolver
ensp
ENSP00000217159
resolver
ensp
ENSP00000690677
resolver
ensp
ENSP00000690681
resolver
ensp
ENSP00000789645
resolver
genesymbol
SLCO4A1
resolver
genesymbol_syn
OATP1
resolver
genesymbol_syn
OATP4A1
resolver
genesymbol_syn
OATPE
resolver
genesymbol_syn
SLC21A12
resolver
hgnc
HGNC:10953
resolver
uniprot
Q9H4T7
resolver
uniprot
Q9H4T8
resolver
uniprot
Q9H8P2
resolver
uniprot
Q9NWX8
resolver
uniprot
Q9UI35
resolver
uniprot
Q9UIG7
resolver
uniprot_entry
SO4A1_HUMAN
resolver
uniprot_sec
Q9H4T7
resolver
uniprot_sec
Q9H4T8
resolver
uniprot_sec
Q9H8P2
resolver
uniprot_sec
Q9NWX8
resolver
uniprot_sec
Q9UI35
resolver
uniprot_sec
Q9UIG7
resolver
amino_acid_sequence
MPLHQLGDKPLTFPSPNSAMENGLDHTPPSRRASPGTPLSPGSLRSAAHSPLDTSKQPLCQLWAEKHGARGTHEVRYVSAGQSVACGWWAFAPPCLQVLNTPKGILFFLCAAAFLQGMTVNGFINTVITSLERRYDLHSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLLMGTGSLVFALPHFTAGRYEVELDAGVRTCPANPGAVCADSTSGLSRYQLVFMLGQFLHGVGATPLYTLGVTYLDENVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELTTESPLWVGAWWVGFLGSGAAAFFTAVPILGYPRQLPGSQRYAVMRAAEMHQLKDSSRGEASNPDFGKTIRDLPLSIWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFFVNKLRLRGSAVIKFCLFCTVVSLLGILVFSLHCPSVPMAGVTASYGGSLLPEGHLNLTAPCNAACSCQPEHYSPVCGSDGLMYFSLCHAGCPAATETNVDGQKVYRDCSCIPQNLSSGFGHATAGKCTSTCQRKPLLLVFIFVVIFFTFLSSIPALTATLRCVRDPQRSFALGIQWIVVRILGGIPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQNSAMSRYILIMGLLYKVLGVLFFAIACFLYKPLSESSDGLETCLPSQSSAPDSATDSQLQSSV
uniprot
proteins
function
FUNCTION: Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (PubMed:10873595, PubMed:19129463, PubMed:30343886). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (PubMed:30343886). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:30343886, ECO:0000305}.
uniprot
proteins
mass_dalton
77193
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
10873595
uniprot
proteins
pubmed
11316767
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12409283
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19129463
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30343886
uniprot
proteins
pubmed
35307651
uniprot
proteins
sequence_length
722
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:30343886}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 104..124; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 171..195; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 223..253; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 273..293; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 308..332; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 379..400; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 421..444; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 449..471; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 581..603; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 613..638; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 672..689; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins