Lef1
entrez
161452
canonical
uniprot
Q9QXN1
canonical
ensembl
ENSRNOG00000010121
resolver
ensp
ENSRNOP00000013694
resolver
ensp
ENSRNOP00000077630
resolver
ensp
ENSRNOP00000085829
resolver
ensp
ENSRNOP00000095160
resolver
enst
ENSRNOT00000013694
resolver
enst
ENSRNOT00000097295
resolver
enst
ENSRNOT00000103221
resolver
enst
ENSRNOT00000117352
resolver
genesymbol
Lef1
resolver
uniprot
A0A8I5Y632
resolver
uniprot
A0A8I6A132
resolver
uniprot
A0A8I6GLH5
resolver
uniprot
G3V7C1
resolver
uniprot_entry
A0A8I5Y632_RAT
resolver
uniprot_entry
A0A8I6A132_RAT
resolver
uniprot_entry
A0A8I6GLH5_RAT
resolver
uniprot_entry
G3V7C1_RAT
resolver
uniprot_entry
LEF1_RAT
resolver
amino_acid_sequence
MPQLSGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNESEIIPASNGHEVVGQTQSSQEPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNMNSDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSEVNPKQGMSRHPPAPEMPTFYPLSPGGVGQITPPLGWQGQPVYPITGGFRQAYPSSLSGDTSMSRFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPEHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESTSGTGPRMTAAYI
uniprot
proteins
function
FUNCTION: Transcription factor that binds DNA in a sequence-specific manner (By similarity). Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity). Regulates T-cell receptor alpha enhancer function (By similarity). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:P27782, ECO:0000250|UniProtKB:Q9UJU2}.
uniprot
proteins
mass_dalton
44023
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-153 and/or Ser-164 by NLK (By similarity). Phosphorylation by NLK at these sites represses LEF1-mediated transcriptional activation of target genes of the canonical Wnt signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q9UJU2}.
uniprot
proteins
protein_family
TCF/LEF family
uniprot
proteins
pubmed
10824856
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. Note=Found in nuclear bodies upon PIASG binding. {ECO:0000250}.
uniprot
proteins