SELENOT
entrez
51714
canonical
uniprot
P62341
canonical
ensembl
ENSG00000198843
resolver
ensp
ENSP00000418910
resolver
enst
ENST00000471696
resolver
genesymbol
SELENOT
resolver
genesymbol_syn
SELT
resolver
hgnc
HGNC:18136
resolver
uniprot
O95904
resolver
uniprot
Q8IY80
resolver
uniprot
Q9CZ45
resolver
uniprot
Q9NZJ3
resolver
uniprot_entry
SELT_HUMAN
resolver
uniprot_sec
O95904
resolver
uniprot_sec
Q8IY80
resolver
uniprot_sec
Q9CZ45
resolver
uniprot_sec
Q9NZJ3
resolver
amino_acid_sequence
MRLLLLLLVAASAMVRSEASANLGGVPSKRLKMQYATGPLLKFQICVSUGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYRHIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS
uniprot
proteins
disease_involvement
DISEASE: Note=mRNA levels are increased more than 200-folds in the caudate putamen from Parkinson disease (PD) patients compared to control subjects. In conditional brain knockout mice, treatment with PD-inducing neurotoxins provoke rapid and severe parkinsonian-like motor defects. {ECO:0000269|PubMed:26866473}.
uniprot
proteins
ec_number
1.8.1.9
uniprot
proteins
function
FUNCTION: Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress and cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity). {ECO:0000250|UniProtKB:P62342, ECO:0000250|UniProtKB:Q1H5H1, ECO:0000269|PubMed:26866473}.
uniprot
proteins
mass_dalton
22324
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="U->S: Increases ROS levels induced by neurotoxins."; /evidence="ECO:0000269|PubMed:26866473
uniprot
proteins
post_translational_modification
PTM: May contain a selenide-sulfide bond between Cys-46 and Sec-49. This bond is speculated to serve as redox-active pair (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
SelWTH family
uniprot
proteins
protein_family
Selenoprotein T subfamily
uniprot
proteins
pubmed
10567350
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23913443
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26866473
uniprot
proteins
pubmed
27645994
uniprot
proteins
sequence_length
195
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q1H5H1}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 85..103; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins