Sult1a1
entrez
83783
canonical
uniprot
P17988
canonical
ensembl
ENSRNOG00000019342
resolver
ensembl
ENSRNOG00055026108
resolver
ensembl
ENSRNOG00060030085
resolver
ensembl
ENSRNOG00065016720
resolver
ensp
ENSRNOP00000026186
resolver
ensp
ENSRNOP00055036964
resolver
ensp
ENSRNOP00060043503
resolver
ensp
ENSRNOP00065021998
resolver
enst
ENSRNOT00000026186
resolver
enst
ENSRNOT00055045066
resolver
enst
ENSRNOT00060052281
resolver
enst
ENSRNOT00065027878
resolver
genesymbol
Sult1a1
resolver
genesymbol_syn
St1a1
resolver
uniprot
Q548D2
resolver
uniprot_entry
ST1A1_RAT
resolver
uniprot_sec
Q548D2
resolver
amino_acid_sequence
MEFSRPPLVHVKGIPLIKYFAETIGPLQNFTAWPDDLLISTYPKSGTTWMSEILDMIYQGGKLEKCGRAPIYARVPFLEFKCPGVPSGLETLEETPAPRLLKTHLPLSLLPQSLLDQKVKVIYIARNAKDVVVSYYNFYNMAKLHPDPGTWDSFLENFMDGEVSYGSWYQHVKEWWELRHTHPVLYLFYEDIKENPKREIKKILEFLGRSLPEETVDSIVHHTSFKKMKENCMTNYTTIPTEIMDHNVSPFMRKGTTGDWKNTFTVAQNERFDAHYAKTMTDCDFKFRCEL
uniprot
proteins
ec_number
2.8.2.1
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine group. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds (PubMed:1513323, PubMed:7889867, PubMed:8447833). Plays an important roles in the sulfonation of endogenous molecules such as steroid hormones (By similarity). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (PubMed:1513323). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. Catalyzes the sulfate conjugation of dopamine. Catalyzes the sulfation of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine), T3 (3,5,3'-triiodothyronine), rT3 (3,3',5'-triiodothyronine) and 3,3'-T2 (3,3'-diiodothyronine), with a substrate preference of 3,3'-T2 > rT3 > T3 > T4 (By similarity). {ECO:0000250|UniProtKB:P50225, ECO:0000269|PubMed:1513323, ECO:0000269|PubMed:7889867, ECO:0000269|PubMed:8447833}.
uniprot
proteins
mass_dalton
33906
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
1511441
uniprot
proteins
pubmed
1513323
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2374726
uniprot
proteins
pubmed
7889867
uniprot
proteins
pubmed
7982943
uniprot
proteins
pubmed
8033271
uniprot
proteins
pubmed
8299966
uniprot
proteins
pubmed
8447833
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1513323}.
uniprot
proteins