PPP1R1A
entrez
5502
canonical
uniprot
Q13522
canonical
ensembl
ENSG00000135447
resolver
ensp
ENSP00000257905
resolver
ensp
ENSP00000658691
resolver
enst
ENST00000257905
resolver
genesymbol
PPP1R1A
resolver
genesymbol_syn
IPP1
resolver
hgnc
HGNC:9286
resolver
uniprot
Q6IB01
resolver
uniprot
Q8TBJ2
resolver
uniprot
Q8WWV2
resolver
uniprot_entry
PPR1A_HUMAN
resolver
uniprot_sec
Q6IB01
resolver
uniprot_sec
Q8TBJ2
resolver
uniprot_sec
Q8WWV2
resolver
amino_acid_sequence
MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTGTQESRPPGIPDTEVESRLGTSGTAKKTAECIPKTHERGSKEPSTKEPSTHIPPLDSKGANSV
uniprot
proteins
function
FUNCTION: Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
uniprot
proteins
mass_dalton
18939
uniprot
proteins
mutagenesis
MUTAGEN 35; /note="T->A: No activity."; /evidence="ECO:0000269|PubMed:8611507"; MUTAGEN 35; /note="T->D: 1000-fold reduction in activity, inhibits equally PP1 and PP2A."; /evidence="ECO:0000269|PubMed:8611507
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-35 is required for activity. {ECO:0000269|PubMed:11564868}.
uniprot
proteins
protein_family
Protein phosphatase inhibitor 1 family
uniprot
proteins
pubmed
11564868
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8611507
uniprot
proteins
sequence_length
171
uniprot
proteins