Prickle2
entrez
312563
canonical
uniprot
A6IBC5
canonical
ensembl
ENSRNOG00000012364
resolver
ensembl
ENSRNOG00055004442
resolver
ensembl
ENSRNOG00060028279
resolver
ensembl
ENSRNOG00065025216
resolver
ensp
ENSRNOP00000016628
resolver
ensp
ENSRNOP00000104444
resolver
ensp
ENSRNOP00055005257
resolver
ensp
ENSRNOP00060041032
resolver
ensp
ENSRNOP00065035614
resolver
enst
ENSRNOT00000155149
resolver
enst
ENSRNOT00055007026
resolver
enst
ENSRNOT00060049158
resolver
enst
ENSRNOT00065043421
resolver
genesymbol
Prickle2
resolver
uniprot
A0ABK0LLG8
resolver
uniprot
F1M0J7
resolver
uniprot_entry
A0ABK0LLG8_RAT
resolver
uniprot_entry
PRIC2_RAT
resolver
uniprot_sec
F1M0J7
resolver
amino_acid_sequence
MVTVMPLEMEKTISKLMFDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVNSPGEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSNQRKRENLGRGNVRPFPVTMTGAICEQCGGQIKGGDIAVFASRAGHGICWHPPCFICTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRCAACDEIIFADECTEAEGRHWHMRHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHIGIDQGQMTYDGQHWHATENCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSAFQNARAKESRRSAKIGKNKGKTEETMLNQHSQLQVSSNRLSADVDPLSVQMDLLSLSSQTPSLNRDPIWRSRDEPFHYGNKMEQNQSQSPLQLLSQCNIRTSYSPGGQAAGAQPDMWAKHFSNPKRSSSMALKGHGGSFIQECREDYYPGRLMSQESYSDMSSQSFSETRGSIPVPKYEEEEEEEEEEGGISTQQCRPRRPLSSLKYTEDMTPTEQTPRGSMESLALSNATGLSAEGGAKRQEHLSRFSMPDLSKDSGMNVSEKLSNMGTLNSSMQFRSAESVRSLLSAQQYQEMEGNLHQLSNPLGYRDLQSHGRMHQSFDFDGGIASSKLPGQEGVHIQPMSERTRRRTTSRDDNRRFRPHRSRRSRRSRSDNALHLASEREVIARLKDRPPLRAREDYDQFVRQRSFQESMGQGSRRDLYSQCPRTVSDLALQNAFGERWGPYFTEYDWCSTCSSSSESDNEGYFLGEPIPQPARLRYVTSDELLHKYSSYGVPKSSTLGGRGQLHSRKRQKSKNCIIS
uniprot
proteins
function
FUNCTION: Is involved in the organization and maintenance of axon initial segment (AIS) cytoskeletal architecture, likely cooperating with IGSF9B to regulate ANK3/ANKG localization to AIS (By similarity). By binding to and regulating ANK3/ANKG, it modulates its ability to bundle microtubules, a crucial mechanism for establishing neuronal polarity and AIS formation (PubMed:36083912). During early embryonic development, has a role in blastocyst formation, likely controlling the redistribution of the microtubule network during embryo compaction and the establishment of apical/basal cell polarity (By similarity). {ECO:0000250|UniProtKB:Q80Y24, ECO:0000269|PubMed:36083912}.
uniprot
proteins
mass_dalton
96094
uniprot
proteins
protein_family
Prickle / espinas / testin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
36083912
uniprot
proteins
sequence_length
847
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic density {ECO:0000269|PubMed:36083912}. Cell projection, axon {ECO:0000269|PubMed:36083912}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q80Y24}. Nucleus {ECO:0000250|UniProtKB:Q80Y24}. Note=In the axon, strongly expressed in the axon initial segment (AIS) (PubMed:36083912). Detected in the nucleus of 2-cell-stage till 16-cell-stage embryos; nuclear expression decreases from the 16-cell stage onwards (By similarity). {ECO:0000250|UniProtKB:Q80Y24, ECO:0000269|PubMed:36083912}.
uniprot
proteins