REP15
entrez
387849
canonical
uniprot
Q6BDI9
canonical
ensembl
ENSG00000174236
resolver
ensp
ENSP00000310335
resolver
enst
ENST00000310791
resolver
genesymbol
REP15
resolver
hgnc
HGNC:33748
resolver
uniprot
B2RU16
resolver
uniprot_entry
REP15_HUMAN
resolver
uniprot_sec
B2RU16
resolver
amino_acid_sequence
MGQKASQQLALKDSKEVPVVCEVVSEAIVHAAQKLKEYLGFEYPPSKLCPAANTLNEIFLIHFITFCQEKGVDEWLTTTKMTKHQAFLFGADWIWTFWGSNKQIKLQLAVQTLQMSSPPPVESKPCDLSNPESRVEESSWKKSRFDKLEEFCNLIGEDCLGLFIIFGMPGKPKDIRGVVLDSVKSQMVRSHLPGGKAVAQFVLETEDCVFIKELLRNCLSKKDGLREVGKVYISIL
uniprot
proteins
function
FUNCTION: Effector that interacts with Rab GTPases in their active form (GTP-bound) including RAB15, RAB3A-D and RAB34. Controls downstream signaling such as cell proliferation and cell migration (PubMed:35871249). Also regulates transferrin receptor recycling from the endocytic recycling compartment (PubMed:16195351, PubMed:35871249). {ECO:0000269|PubMed:16195351, ECO:0000269|PubMed:35871249}.
uniprot
proteins
mass_dalton
26571
uniprot
proteins
mutagenesis
MUTAGEN 84; /note="H->A: No change in binding affinity with RAB3A. Loss of interaction with RAB3A; when associated with A-85."; /evidence="ECO:0000269|PubMed:35871249"; MUTAGEN 85; /note="Q->A: Decreased interaction with RAB3A. Loss of interaction with RAB3A; when associated with A-84."; /evidence="ECO:0000269|PubMed:35871249"; MUTAGEN 88; /note="L->A: Decreased interaction with RAB3A."; /evidence="ECO:0000269|PubMed:35871249"; MUTAGEN 107; /note="Q->A: Loss of interaction with RAB3A."; /evidence="ECO:0000269|PubMed:35871249"; MUTAGEN 135; /note="V->A: No change in binding affinity with RAB3A."; /evidence="ECO:0000269|PubMed:35871249"; MUTAGEN 140; /note="W->A: No change in binding affinity with RAB3A."; /evidence="ECO:0000269|PubMed:35871249"; MUTAGEN 154; /note="L->A: Loss of interaction with RAB3A; when associated with A-155."; /evidence="ECO:0000269|PubMed:35871249"; MUTAGEN 155; /note="I->A: Loss of interaction with RAB3A; when associated with A-154."; /evidence="ECO:0000269|PubMed:35871249"; MUTAGEN 158; /note="D->A: Decreased interaction with RAB3A."; /evidence="ECO:0000269|PubMed:35871249
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16195351
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
35871249
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:16195351}. Note=Colocalizes with RAB11 and RAB15 to the endocytic recycling compartment.
uniprot
proteins