Foxp1
entrez
108655
canonical
uniprot
P58462
canonical
ensembl
ENSMUSG00000030067
resolver
ensp
ENSMUSP00000108948
resolver
ensp
ENSMUSP00000108950
resolver
ensp
ENSMUSP00000108952
resolver
ensp
ENSMUSP00000108954
resolver
ensp
ENSMUSP00000134817
resolver
ensp
ENSMUSP00000135041
resolver
ensp
ENSMUSP00000135181
resolver
ensp
ENSMUSP00000135764
resolver
ensp
ENSMUSP00000135809
resolver
ensp
ENSMUSP00000219652
resolver
ensp
ENSMUSP00000219653
resolver
ensp
ENSMUSP00000219655
resolver
ensp
ENSMUSP00000219656
resolver
ensp
ENSMUSP00000219659
resolver
ensp
ENSMUSP00000219660
resolver
ensp
ENSMUSP00000219661
resolver
ensp
ENSMUSP00000219663
resolver
enst
ENSMUST00000113326
resolver
enst
ENSMUST00000113328
resolver
enst
ENSMUST00000176565
resolver
enst
ENSMUST00000177229
resolver
enst
ENSMUST00000177307
resolver
enst
ENSMUST00000177437
resolver
genesymbol
Foxp1
resolver
genesymbol_syn
Foxp1a
resolver
uniprot
A0A0R4J1H9
resolver
uniprot
A0A0R4J282
resolver
uniprot
D3Z6Q3
resolver
uniprot
E2S038
resolver
uniprot
H3BJ24
resolver
uniprot
H3BJY9
resolver
uniprot
H3BLF2
resolver
uniprot
Q6P221
resolver
uniprot
Q8C5V2
resolver
uniprot
Q8CCD9
resolver
uniprot_entry
A0A0R4J1H9_MOUSE
resolver
uniprot_entry
A0A0R4J282_MOUSE
resolver
uniprot_entry
D3Z6Q3_MOUSE
resolver
uniprot_entry
E2S038_MOUSE
resolver
uniprot_entry
FOXP1_MOUSE
resolver
uniprot_entry
H3BJ24_MOUSE
resolver
uniprot_entry
H3BJY9_MOUSE
resolver
uniprot_entry
H3BLF2_MOUSE
resolver
uniprot_sec
Q6P221
resolver
uniprot_sec
Q8C5V2
resolver
uniprot_sec
Q8CCD9
resolver
amino_acid_sequence
MMQESGSETKSNGSAIQNGSSGGNHLLECGALRDTRSNGEAPAVDLGAADLAHVQQQQQQALQVARQLLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVSGLKSPKRNDKQPALQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQLQEFYKKQQEQLQLQLLQQQHAGKQPKEQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLAQGMIPTELQQLWKEVTSAHTAEETTSSNHSSLDLTSTCVSSSAPSKSSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCDDFPAFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPTLGSLASAIREELNGAMEHTNSNESDSSPGRSPMQAVHPIHVKEEPLDPEEAEGPLSLVTTANHSPDFDHDRDYEDEPVNEDME
uniprot
proteins
function
FUNCTION: Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (PubMed:11358962, PubMed:14701752). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2 (PubMed:11358962, PubMed:22675208). Essential transcriptional regulator of B-cell development (PubMed:16819554). Involved in regulation of cardiac muscle cell proliferation (PubMed:20713518). Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins (PubMed:18662545, PubMed:18667151). Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3 (PubMed:20175877). Negatively regulates the differentiation of T follicular helper cells T(FH)s (PubMed:24859450). Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (PubMed:23946441). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling (By similarity). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (By similarity). {ECO:0000250|UniProtKB:Q9H334, ECO:0000269|PubMed:14701752, ECO:0000269|PubMed:16819554, ECO:0000269|PubMed:18662545, ECO:0000269|PubMed:18667151, ECO:0000269|PubMed:20175877, ECO:0000269|PubMed:20713518, ECO:0000269|PubMed:22675208, ECO:0000269|PubMed:23946441, ECO:0000269|PubMed:24859450, ECO:0000305|PubMed:20175877, ECO:0000305|PubMed:22675208, ECO:0000305|PubMed:23946441}.; FUNCTION: [Isoform 5]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (By similarity). Promotes ESC self-renewal and pluripotency (PubMed:21924763). {ECO:0000250|UniProtKB:Q9H334, ECO:0000269|PubMed:21924763}.
uniprot
proteins
mass_dalton
78833
uniprot
proteins
mutagenesis
MUTAGEN 388; /note="Missing: Loss of dimerization. Almost complete loss of DNA-binding. Reduced transcriptional repression activity."; /evidence="ECO:0000269|PubMed:14701752"; MUTAGEN 410..414; /note="PLNLV->AANAA: No significant effect on transcriptional repression activity."; /evidence="ECO:0000269|PubMed:14701752
uniprot
proteins
pubmed
11358962
uniprot
proteins
pubmed
14516685
uniprot
proteins
pubmed
14701752
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16819554
uniprot
proteins
pubmed
18662545
uniprot
proteins
pubmed
18667151
uniprot
proteins
pubmed
20175877
uniprot
proteins
pubmed
20713518
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21924763
uniprot
proteins
pubmed
22675208
uniprot
proteins
pubmed
23946441
uniprot
proteins
pubmed
24859450
uniprot
proteins
sequence_length
705
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H334}. Note=Not found in the nucleolus. {ECO:0000250|UniProtKB:Q9H334}.
uniprot
proteins