Ebp
entrez
117278
canonical
uniprot
Q9JJ46
canonical
ensembl
ENSRNOG00000004903
resolver
ensembl
ENSRNOG00055022904
resolver
ensembl
ENSRNOG00060024445
resolver
ensembl
ENSRNOG00065011424
resolver
ensp
ENSRNOP00000007015
resolver
ensp
ENSRNOP00055031912
resolver
ensp
ENSRNOP00060035098
resolver
ensp
ENSRNOP00065014191
resolver
enst
ENSRNOT00000007015
resolver
enst
ENSRNOT00055039331
resolver
enst
ENSRNOT00060042338
resolver
enst
ENSRNOT00065018558
resolver
genesymbol
Ebp
resolver
genesymbol_syn
Rsi
resolver
uniprot
Q548M8
resolver
uniprot_entry
EBP_RAT
resolver
uniprot_sec
Q548M8
resolver
activity_regulation
ACTIVITY REGULATION: Enzymatic activity is induced by 25-hydroxycholesterol, cholestyramine and lovastatin. {ECO:0000269|PubMed:11171067}.
uniprot
proteins
amino_acid_sequence
MTTNMLPLHPYWPRHLRLDNFVPNDLPTWHILVGLFSFSGVLIVITWLLSSRVSVVPLGTGRRLALCWFAVCTFIHLVIEGWFSFYHEILLEDQAFLSQLWKEYSKGDSRYILSDGFIVCMESVTACLWGPLSLWVVIAFLRHQPFRFVLQLVVSVGQIYGDVLYFLTELRDGFQHGELGHPLYFWFYFVIMNAIWLVIPGILVFDAIKHLTNAQSMLDNKVMKIKSKHN
uniprot
proteins
ec_number
3.3.2.11
uniprot
proteins
ec_number
5.3.3.5
uniprot
proteins
function
FUNCTION: Isomerase that catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. {ECO:0000269|PubMed:11171067}.; FUNCTION: Component of the microsomal antiestrogen binding site (AEBS), a multiproteic complex at the ER membrane that consists of an association between EBP and 7-dehydrocholesterol reductase/DHCR7. This complex is responsible for cholesterol-5,6-epoxide hydrolase (ChEH) activity, which consists in the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3beta,5alpha,6beta-triol (CT). The precise role of each component of this complex has not been described yet. {ECO:0000250|UniProtKB:Q15125}.
uniprot
proteins
mass_dalton
26738
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; cholesterol biosynthesis. {ECO:0000269|PubMed:11171067}.
uniprot
proteins
protein_family
EBP family
uniprot
proteins
pubmed
11171067
uniprot
proteins
sequence_length
230
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15125}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q15125}. Nucleus envelope {ECO:0000250|UniProtKB:Q15125}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q15125}. Note=During interphase, detected on the endoplasmic reticulum and the nuclear envelope. During mitosis, detected on cytoplasmic vesicles. {ECO:0000250|UniProtKB:Q15125}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..49; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 66..86; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 121..141; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins