Tlr8
entrez
170744
canonical
uniprot
P58682
canonical
ensembl
ENSMUSG00000040522
resolver
ensp
ENSMUSP00000036762
resolver
ensp
ENSMUSP00000107793
resolver
enst
ENSMUST00000049023
resolver
enst
ENSMUST00000112170
resolver
genesymbol
Tlr8
resolver
uniprot
A2AHI9
resolver
uniprot
Q91XI7
resolver
uniprot_entry
TLR8_MOUSE
resolver
uniprot_sec
A2AHI9
resolver
uniprot_sec
Q91XI7
resolver
activity_regulation
ACTIVITY REGULATION: Activated by RNAs having enough uridines. {ECO:0000250|UniProtKB:Q9NR97}.
uniprot
proteins
amino_acid_sequence
MENMPPQSWILTCFCLLSSGTSAIFHKANYSRSYPCDEIRHNSLVIAECNHRQLHEVPQTIGKYVTNIDLSDNAITHITKESFQKLQNLTKIDLNHNAKQQHPNENKNGMNITEGALLSLRNLTVLLLEDNQLYTIPAGLPESLKELSLIQNNIFQVTKNNTFGLRNLERLYLGWNCYFKCNQTFKVEDGAFKNLIHLKVLSLSFNNLFYVPPKLPSSLRKLFLSNAKIMNITQEDFKGLENLTLLDLSGNCPRCYNAPFPCTPCKENSSIHIHPLAFQSLTQLLYLNLSSTSLRTIPSTWFENLSNLKELHLEFNYLVQEIASGAFLTKLPSLQILDLSFNFQYKEYLQFINISSNFSKLRSLKKLHLRGYVFRELKKKHFEHLQSLPNLATINLGINFIEKIDFKAFQNFSKLDVIYLSGNRIASVLDGTDYSSWRNRLRKPLSTDDDEFDPHVNFYHSTKPLIKPQCTAYGKALDLSLNNIFIIGKSQFEGFQDIACLNLSFNANTQVFNGTEFSSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNAHYFSIAGVTHRLGFIQNLINLRVLNLSHNGIYTLTEESELKSISLKELVFSGNRLDRLWNANDGKYWSIFKSLQNLIRLDLSYNNLQQIPNGAFLNLPQSLQELLISGNKLRFFNWTLLQYFPHLHLLDLSRNELYFLPNCLSKFAHSLETLLLSHNHFSHLPSGFLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSILELHGNYFDCTCDISDFRSWLDENLNITIPKLVNVICSNPGDQKSKSIMSLDLTTCVSDTTAAVLFFLTFLTTSMVMLAALVHHLFYWDVWFIYHMCSAKLKGYRTSSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQYSQYLRLRQRICKSSILQWPNNPKAENLFWQSLKNVVLTENDSRYDDLYIDSIRQY
uniprot
proteins
function
FUNCTION: Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively. {ECO:0000250|UniProtKB:Q9NR97}.
uniprot
proteins
mass_dalton
119358
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by RNF216; leading to degradation by the proteasome. {ECO:0000250|UniProtKB:Q9NR97}.; PTM: Proteolytic processing occurs in monocytes and monocyte-derived macrophages by both furin-like proprotein convertase and cathepsins. The cleavage is necessary for dimer formation and subsequent activation. {ECO:0000250|UniProtKB:Q9NR97}.
uniprot
proteins
protein_family
Toll-like receptor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19451267
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26095358
uniprot
proteins
sequence_length
1032
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q9NR97}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9NR97}. Note=Endosomal localization confers distinctive proteolytic processing. {ECO:0000250|UniProtKB:Q9NR97}.
uniprot
proteins
transmembrane_region
TRANSMEM 819..839; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins