Pex6
entrez
117265
canonical
uniprot
P54777
canonical
ensembl
ENSRNOG00000016655
resolver
ensp
ENSRNOP00000022582
resolver
enst
ENSRNOT00000022582
resolver
genesymbol
Pex6
resolver
uniprot
O55097
resolver
uniprot_entry
PEX6_RAT
resolver
uniprot_sec
O55097
resolver
amino_acid_sequence
MALAVLHVLEPFPTETPPLAVLLPPGGPWPVTGVGLVLALRPASESPAGPALLVAAVEGSGAQCEQRGPGPPPLLVSRTLLRVLALSPGARVRARPVRRPPALGWALLGTSPGPGLGPRVGPLLVRRGETLPVPGSRVLETRPALQGLLGPGTRLAVTELQGRTKLDPESRDHNHPPPPPVVSSFAVSHSIRQLRGVLGGTGDALGVSRSCLRSLGLFQGEWVWVARVGELPNTSQPHLAQVQVLEPRWDLSARLGPNSGQPGEPLADGLVFVPATLAFNLGCDPLEVGELRIQRYLEDSTAAEDKGSCSLLPGPPFARELHIEVLPSPHCGVNGKYDHVLYQHFHTPRVVQEGDVLCVSTAGQVEILEGSLERLPRWREVFFKVKKTVGEAPDGPASAFLADTTHTSLYLAGTTLSRVPPLPSGRSPPWDSLSPPGLEALVNELCAVLKPHLQPGGTLLTGTSCVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRTVETKLQTTFSRARRCRPVVLLLTALDLLGRDRDGLGEDARVVATLRHLLLDEDPLSRCPPLMVVATTSRVQDLPTDVRTAFPHELEVPVLSESQRLSVLQALTAHLPLGQEVNLSQLARRCAGFVVGDLYALLTHASRAACTRIKAAGLAMSEEDEGELCAAGFPLLAEDFGQALDQLQTAHSQAVGAPKIPSVSWHDVGGLQDVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGASEDRASQLRVLSAITRKFKLEASVSLMNVLDCCPPQLTGADLYSLCSDAMMTALKRRVRDLEEGLEPRSSALLLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAAC
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5. {ECO:0000250|UniProtKB:Q13608}.
uniprot
proteins
mass_dalton
104426
uniprot
proteins
mutagenesis
MUTAGEN 476; /note="K->A: No loss of function."; /evidence="ECO:0000269|PubMed:7493019"; MUTAGEN 748; /note="K->A: Loss of function."; /evidence="ECO:0000269|PubMed:7493019
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
7493019
uniprot
proteins
sequence_length
978
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q13608}. Peroxisome membrane {ECO:0000250|UniProtKB:Q13608}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q13608}. Note=Associated with peroxisomal membranes; anchored by PEX26 to peroxisome membranes. Localized at the base of the outer segment of photoreceptor cells. {ECO:0000250|UniProtKB:Q13608}.
uniprot
proteins