MEI4
entrez
101928601
canonical
uniprot
A8MW99
canonical
ensembl
ENSG00000269964
resolver
ensp
ENSP00000473370
resolver
ensp
ENSP00000496917
resolver
ensp
ENSP00000507827
resolver
enst
ENST00000602452
resolver
enst
ENST00000649759
resolver
enst
ENST00000684080
resolver
genesymbol
MEI4
resolver
hgnc
HGNC:43638
resolver
uniprot
R4GMV8
resolver
uniprot_entry
MEI4_HUMAN
resolver
uniprot_sec
R4GMV8
resolver
amino_acid_sequence
MDVQKWYLRTSKLALALAIIRSKPADKSSREYTEHLAMLLSEEQSKWRSKVEILEAEVMQLRQKLLVSRLCSGSFKSGYVSSQLEAQEPKSSESTLTSMEDSGCDLSNEQRTESSDLSQHFVESCTPTHFPPLPLVKRPCAILQNPLSSHMQFLQYLLELKNLTESGNLKRDLTHFEKDSSTVSDSVFQLLDGLITFYRNPKLPFSRFWTEAVGTLASLISDYNLSSHILKKCSKKLEEFEKTLLHAILGNNHINQFQVQHYVSQSLVTLGNCSLLRKSIISLLLSEVNGFADDLGAINQEQASYDVSRYENIFYLFWVLEQLLQKETEEGNTSSIGHDDQEIKKFLQKHDETIFQLSDAFPLFTFYLWRVGILLSSAQIETLRK
uniprot
proteins
function
FUNCTION: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. {ECO:0000250|UniProtKB:Q8BRM6}.
uniprot
proteins
mass_dalton
44024
uniprot
proteins
protein_family
MEI4L family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
31704776
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q8BRM6}. Note=Specifically localizes to unsynapsed chromosomal regions during meiosis. Located in discrete foci on the axes of meiotic chromosomes. The number of foci is highest at leptonema, decreases at zygonema and is strongly reduced in pachynema and subsequent stages. {ECO:0000250|UniProtKB:Q8BRM6}.
uniprot
proteins