Reg3g
entrez
19695
canonical
uniprot
O09049
canonical
ensembl
ENSMUSG00000030017
resolver
ensp
ENSMUSP00000032089
resolver
enst
ENSMUST00000032089
resolver
genesymbol
Reg3g
resolver
genesymbol_syn
Pap3
resolver
uniprot
Q545I1
resolver
uniprot_entry
Q545I1_MOUSE
resolver
uniprot_entry
REG3G_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: [Regenerating islet-derived protein 3-gamma 15 kDa form]: Lipopolysaccharide inhibits pore-forming activity, explaining why is bactericidal for Gram-positive but not Gram-negative bacteria. {ECO:0000250|UniProtKB:Q06141}.
uniprot
proteins
amino_acid_sequence
MLPRITITIMSWMLLSCLMLLSQVQGEVAKKDAPSSRSSCPKGSRAYGSYCYALFSVSKNWYDADMACQKRPSGHLVSVLSGAEASFLSSMIKSSGNSGQYVWIGLHDPTLGYEPNRGGWEWSNADVMNYINWETNPSSSSGNHCGTLSRASGFLKWRENYCNLELPYVCKFKA
uniprot
proteins
function
FUNCTION: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. {ECO:0000269|PubMed:16504538, ECO:0000269|PubMed:16931762, ECO:0000269|PubMed:17635956, ECO:0000269|PubMed:21998396, ECO:0000269|PubMed:22727489, ECO:0000269|PubMed:23401489}.; FUNCTION: Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Is secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways (PubMed:22727489, PubMed:27830702, PubMed:36240758). Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury (PubMed:22727489). In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF (PubMed:27830702). Induced by IL22 in lung epithelial cells, inhibits cytokine production and regulates allergic airway inflammation (PubMed:28811323). Induced in small intestine by inulin-enriched diet and Lactobacillus gasseri enriched microbiome, plays a role in the improvement of gut barrier function, the regulation of energy balance and glucose levels. Modulates microbiota composition in duodenal contents (PubMed:36240758). Produced by nociceptor in response to endotoxins, prevents endotoxic death by targeting kynurenine pathway in microglia (PubMed:35263589). {ECO:0000269|PubMed:22727489, ECO:0000269|PubMed:27830702, ECO:0000269|PubMed:28811323, ECO:0000269|PubMed:35263589, ECO:0000269|PubMed:36240758}.; FUNCTION: [Regenerating islet-derived protein 3-gamma 16.5 kDa form]: Has bacteriostatic activity. {ECO:0000269|PubMed:19095652}.; FUNCTION: [Regenerating islet-derived protein 3-gamma 15 kDa form]: Has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. {ECO:0000269|PubMed:19095652}.
uniprot
proteins
mass_dalton
19307
uniprot
proteins
post_translational_modification
PTM: Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. {ECO:0000269|PubMed:19095652}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16504538
uniprot
proteins
pubmed
16931762
uniprot
proteins
pubmed
17635956
uniprot
proteins
pubmed
19095652
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21998396
uniprot
proteins
pubmed
22727489
uniprot
proteins
pubmed
23401489
uniprot
proteins
pubmed
27830702
uniprot
proteins
pubmed
28811323
uniprot
proteins
pubmed
35263589
uniprot
proteins
pubmed
36240758
uniprot
proteins
pubmed
9055810
uniprot
proteins
sequence_length
174
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28811323, ECO:0000269|PubMed:36240758}. Cytoplasm {ECO:0000250|UniProtKB:P42854}.
uniprot
proteins