PARD3
entrez
56288
canonical
uniprot
Q8TEW0
canonical
ensembl
ENSG00000148498
resolver
ensp
ENSP00000311986
resolver
ensp
ENSP00000340591
resolver
ensp
ENSP00000341844
resolver
ensp
ENSP00000363905
resolver
ensp
ENSP00000363908
resolver
ensp
ENSP00000363920
resolver
ensp
ENSP00000363921
resolver
ensp
ENSP00000363926
resolver
ensp
ENSP00000440857
resolver
ensp
ENSP00000443147
resolver
ensp
ENSP00000596381
resolver
genesymbol
PARD3
resolver
genesymbol_syn
PAR3
resolver
genesymbol_syn
PAR3A
resolver
hgnc
HGNC:16051
resolver
uniprot
F5H5T0
resolver
uniprot
Q5T2U1
resolver
uniprot
Q5VUA2
resolver
uniprot
Q5VUA3
resolver
uniprot
Q5VWV0
resolver
uniprot
Q5VWV1
resolver
uniprot
Q5VWV3
resolver
uniprot
Q5VWV4
resolver
uniprot
Q5VWV5
resolver
uniprot
Q6IQ47
resolver
uniprot
Q8TCZ9
resolver
uniprot
Q8TEW1
resolver
uniprot
Q8TEW2
resolver
uniprot
Q8TEW3
resolver
uniprot
Q96K28
resolver
uniprot
Q96RM6
resolver
uniprot
Q96RM7
resolver
uniprot
Q9BY57
resolver
uniprot
Q9BY58
resolver
uniprot
Q9HC48
resolver
uniprot
Q9NWL4
resolver
uniprot
Q9NYE6
resolver
uniprot_entry
PARD3_HUMAN
resolver
uniprot_sec
F5H5T0
resolver
uniprot_sec
Q5T2U1
resolver
uniprot_sec
Q5VUA2
resolver
uniprot_sec
Q5VUA3
resolver
uniprot_sec
Q5VWV0
resolver
uniprot_sec
Q5VWV1
resolver
uniprot_sec
Q5VWV3
resolver
uniprot_sec
Q5VWV4
resolver
uniprot_sec
Q5VWV5
resolver
uniprot_sec
Q6IQ47
resolver
uniprot_sec
Q8TCZ9
resolver
uniprot_sec
Q8TEW1
resolver
uniprot_sec
Q8TEW2
resolver
uniprot_sec
Q8TEW3
resolver
uniprot_sec
Q96K28
resolver
uniprot_sec
Q96RM6
resolver
uniprot_sec
Q96RM7
resolver
uniprot_sec
Q9BY57
resolver
uniprot_sec
Q9BY58
resolver
uniprot_sec
Q9HC48
resolver
uniprot_sec
Q9NWL4
resolver
uniprot_sec
Q9NYE6
resolver
amino_acid_sequence
MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWIQVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANMPLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASHPMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETLEEDTEESSRSGRESVSTASDQPSHSLERQMNGNQEKGDKTDRKKDKTGKEKKKDRDKEKDKMKAKKGMLKGLGDMFRFGKHRKDDKIEKTGKIKIQESFTSEEERIRMKQEQERIQAKTREFRERQARERDYAEIQDFHRTFGCDDELMYGGVSSYEGSMALNARPQSPREGHMMDALYAQVKKPRNSKPSPVDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQPWPNARPATQSGRHSVSVEVQMQRQRQEERESSQQAQRQYSSLPRQSRKNASSVSQDSWEQNYSPGEGFQSAKENPRYSSYQGSRNGYLGGHGFNARVMLETQELLRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPSYAPPKGPFRQDVPPSPSQVARLNRLQTPEKGRPFYS
uniprot
proteins
disease_involvement
DISEASE: Neural tube defects (NTD) [MIM:182940]: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. {ECO:0000269|PubMed:27925688}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}.
uniprot
proteins
mass_dalton
151423
uniprot
proteins
mutagenesis
MUTAGEN 962; /note="S->A: Abolishes phosphorylation by AURKA."; /evidence="ECO:0000269|PubMed:19812038"; MUTAGEN 1127; /note="Y->F: Delayed epithelial tight junction assembly.
uniprot
proteins
post_translational_modification
PTM: Acetylated. Deacetylated by SIRT2, thereby inhibiting Schwann cell peripheral myelination. {ECO:0000269|PubMed:21949390}.; PTM: Phosphorylation at Ser-827 by PRKCZ and PRKCI occurs at the most apical tip of epithelial cell-cell contacts during the initial phase of tight junction formation and may promote dissociation of the complex with PARD6. EGF-induced Tyr-1127 phosphorylation mediates dissociation from LIMK2 (By similarity). Phosphorylation by AURKA at Ser-962 is required for the normal establishment of neuronal polarity (PubMed:19812038). {ECO:0000250, ECO:0000269|PubMed:19812038}.
uniprot
proteins
protein_family
PAR3 family
uniprot
proteins
pubmed
10934474
uniprot
proteins
pubmed
10954424
uniprot
proteins
pubmed
11149944
uniprot
proteins
pubmed
11257119
uniprot
proteins
pubmed
11642408
uniprot
proteins
pubmed
12234671
uniprot
proteins
pubmed
12459187
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15254234
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16678097
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18838552
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19812038
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20073081
uniprot
proteins
pubmed
20332120
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21949390
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23832200
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26766442
uniprot
proteins
pubmed
27925688
uniprot
proteins
sequence_length
1356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endomembrane system {ECO:0000269|PubMed:20332120}. Cell junction {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:27925688}. Cell junction, tight junction {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:27925688}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q99NH2}. Cell membrane {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:27925688}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20332120}. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II. Colocalized with SIRT2 in internode region of myelin sheath (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.
uniprot
proteins