DDX56
entrez
54606
canonical
uniprot
Q9NY93
canonical
ensembl
ENSG00000136271
resolver
ensp
ENSP00000258772
resolver
ensp
ENSP00000393488
resolver
genesymbol
DDX56
resolver
genesymbol_syn
DDX21
resolver
genesymbol_syn
NOH61
resolver
hgnc
HGNC:18193
resolver
uniprot
A4D2K9
resolver
uniprot
C9JV95
resolver
uniprot
Q6IAE2
resolver
uniprot
Q9H9I8
resolver
uniprot_entry
DDX56_HUMAN
resolver
uniprot_sec
A4D2K9
resolver
uniprot_sec
C9JV95
resolver
uniprot_sec
Q6IAE2
resolver
uniprot_sec
Q9H9I8
resolver
amino_acid_sequence
MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQAQSMIQQLATYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAEVLGAPVKGKRRGRGPKGDKASDPEAGVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIEELLSGENRGPILLPYQFRMEEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGHVPDYLVPPALRGLVRPHKKRKKLSSSCRKAKRAKSQNPLRSFKHKGKKFRPTAKPS
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization (PubMed:31340999, PubMed:33789112). Plays an essential role in maintaining nucleolar integrity in planarian stem cells (PubMed:33789112). Maintains embryonic stem cells proliferation by conventional regulation of ribosome assembly and interaction with OCT4 and POU5F1 complex (By similarity). Regulates antiviral innate immunity by inhibiting the virus-triggered signaling nuclear translocation of IRF3 (PubMed:31340999). Mechanistically, acts by disrupting the interaction between IRF3 and importin IPO5 (PubMed:31340999). May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity. {ECO:0000250|UniProtKB:Q9D0R4, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:33789112}.; FUNCTION: (Microbial infection) Helicase activity is important for packaging viral RNA into virions during West Nile virus infection. {ECO:0000269|PubMed:22925334}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease virus replication by inhibiting the phosphorylation of IRF3 leading to inhibition of type I interferon. {ECO:0000269|PubMed:31445188}.; FUNCTION: (Microbial infection) Plays a positive role in EMCV replication by interrupting IRF3 phosphorylation and its nucleus translocation. {ECO:0000269|PubMed:34922148}.
uniprot
proteins
mass_dalton
61590
uniprot
proteins
mutagenesis
MUTAGEN 166; /note="D->N: Complete loss of interaction with IRF3. About 3-4 times less genomic RNA in West Nile virus particles."; /evidence="ECO:0000269|PubMed:17525332, ECO:0000269|PubMed:22925334"; MUTAGEN 167; /note="E->Q: Complete loss of interaction with IRF3. About 3-4 times less genomic RNA in West Nile virus particles."; /evidence="ECO:0000269|PubMed:17525332, ECO:0000269|PubMed:22925334
uniprot
proteins
protein_family
DDX56/DBP9 subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
10749921
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22925334
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
31340999
uniprot
proteins
pubmed
31445188
uniprot
proteins
pubmed
33789112
uniprot
proteins
pubmed
34922148
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:22925334, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:33789112}.
uniprot
proteins