Rab5a
entrez
271457
canonical
uniprot
Q9CQD1
canonical
ensembl
ENSMUSG00000017831
resolver
ensp
ENSMUSP00000017975
resolver
enst
ENSMUST00000017975
resolver
genesymbol
Rab5a
resolver
genesymbol_syn
nnyRab5a
resolver
uniprot
Q3UCX7
resolver
uniprot
Q4VAA1
resolver
uniprot
Q9DCN5
resolver
uniprot_entry
RAB5A_MOUSE
resolver
uniprot_sec
Q3UCX7
resolver
uniprot_sec
Q4VAA1
resolver
uniprot_sec
Q9DCN5
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including RINL and RABGEF1, which promote the exchange of bound GDP for free GTP (By similarity). Regulated by GTPase activating proteins (GAPs) including SGSM3, which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) (By similarity). {ECO:0000250|UniProtKB:P18066, ECO:0000250|UniProtKB:P20339}.
uniprot
proteins
amino_acid_sequence
MANRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLTEPAQPARSQCCSN
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes and involved in early endocytic trafficking (PubMed:18425118). Required for EEA1 recruitment to early endosomes. Recruits FERRY complex to early endosomes, where FERRY links early endosomes with a subgroup of mRNAs to enable mRNA intracellular distribution (By similarity). Recruits RABEP1/Rabaptin-5 effector to early endosomes, thereby promoting endocytic membrane fusion (By similarity). Required for EGF and transferrin endocytosis and trafficking through early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (By similarity). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity) (PubMed:18425118). {ECO:0000250|UniProtKB:P18066, ECO:0000250|UniProtKB:P20339, ECO:0000269|PubMed:18425118}.
uniprot
proteins
mass_dalton
23599
uniprot
proteins
mutagenesis
MUTAGEN 34; /note="S->N: Inhibits endosome localization. Disrupts interaction of RAB5A and OCRL with INPP5F. Prevents its localization to apoptotic cell corpse-containing early phagosomes. Maturation of apoptotic cell-containing phagosome into acidic phagosomes is decreased. Interacts with PIK3C3."; /evidence="ECO:0000269|PubMed:18425118, ECO:0000269|PubMed:25869668"; MUTAGEN 79; /note="Q->L: Induces the formation of larger endosomes. No effect on interaction with INPP5F. Prevents interaction with DYN2 without affecting the interaction with PIK3C3."; /evidence="ECO:0000269|PubMed:18425118, ECO:0000269|PubMed:25869668
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including RAB GDP dissociation inhibitors GDI1 and GDI2. {ECO:0000250|UniProtKB:P20339}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11773082
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16923123
uniprot
proteins
pubmed
17509819
uniprot
proteins
pubmed
18425118
uniprot
proteins
pubmed
21059846
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25568335
uniprot
proteins
pubmed
25869668
uniprot
proteins
sequence_length
215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20339}; Lipid-anchor {ECO:0000250|UniProtKB:P20339}; Cytoplasmic side {ECO:0000250|UniProtKB:P18066}. Early endosome membrane {ECO:0000250|UniProtKB:P20339}; Lipid-anchor {ECO:0000250|UniProtKB:P20339}. Melanosome {ECO:0000269|PubMed:25869668}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P20339}. Cell projection, ruffle {ECO:0000250|UniProtKB:P18066}. Membrane {ECO:0000250|UniProtKB:P20339}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P20339}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:18425118}. Endosome membrane {ECO:0000250|UniProtKB:P20339}. Note=Enriched in stage I melanosomes. Alternates between membrane-bound and cytosolic forms. {ECO:0000250|UniProtKB:P20339}.
uniprot
proteins