Fxyd5
entrez
60338
canonical
uniprot
P59647
canonical
ensembl
ENSRNOG00000021062
resolver
ensp
ENSRNOP00000068919
resolver
genesymbol
Fxyd5
resolver
uniprot
Q6P9W0
resolver
uniprot_entry
FXYD5_RAT
resolver
uniprot_sec
Q6P9W0
resolver
amino_acid_sequence
MSPPSQLCLLTIVALILPSEGQTPEKPRSSFTAHQSSVTTHVPVPDQTSPGVQTTPPIWTSEAGEATGSQTAAKTKTQQLTEMATANPVTDPGPLTSSEKGTPALSRIKSPSPPKGYMPPSYIENPLDPNENSPFYYDNTTLRKRGLLVAAVLFITGIIILTSGKCRQFSQLCLNRHR
uniprot
proteins
function
FUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (By similarity). May increase NKA activity by increasing the apparent affinity for Na(+). Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis (By similarity). {ECO:0000250|UniProtKB:P97808, ECO:0000250|UniProtKB:Q96DB9}.
uniprot
proteins
mass_dalton
19128
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q96DB9}.
uniprot
proteins
protein_family
FXYD family
uniprot
proteins
pubmed
10950925
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
178
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P97808}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P97808}. Basolateral cell membrane {ECO:0000250|UniProtKB:P97808}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P97808}. Note=In kidneys localizes to the basolateral membrane of the connecting tubule. {ECO:0000250|UniProtKB:P97808}.
uniprot
proteins
transmembrane_region
TRANSMEM 147..164; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins