Fbxo42
entrez
213499
canonical
uniprot
Q6PDJ6
canonical
ensembl
ENSMUSG00000028920
resolver
ensp
ENSMUSP00000030757
resolver
ensp
ENSMUSP00000285705
resolver
enst
ENSMUST00000030757
resolver
genesymbol
Fbxo42
resolver
uniprot
A2A824
resolver
uniprot
Q8CE76
resolver
uniprot
Q99KY2
resolver
uniprot_entry
FBX42_MOUSE
resolver
uniprot_sec
A2A824
resolver
uniprot_sec
Q8CE76
resolver
uniprot_sec
Q99KY2
resolver
amino_acid_sequence
MASSSDSEDDSVMAVDQEETALEGTMEQDEDPHPVLEVEETRHNRSMSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKGVAHQCYHGFMKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIGDKMIVFGGSLGSRQMSNEVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDTTLLILGGCGGPNALFKDAWLLHMHPGPWAWQPLKVENEDHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPILNGGNLSPGTVAVGGASLDSPVQVVSPSTPSASDGYDLKVGLSLAPRRGSLPDQKDLRLSSIDLNWDLKSASSSSHVDSIDNRTVAGSVRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPSSPGSQSLSSGETVPNSRPGPAQGDGHSLPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFTSSSVVGPPETSLHTVVQGRGELIVFGGLMDKKQNVKYYPKTNALYFVRAKR
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for bipolar spindle formation during mitosis. Recognizes p53/TP53 phosphorylated by CSN-associated kinase, promoting its polyubiquitination and proteasomal degradation. Positively regulates the Notch signaling pathway through 'Lys-63'-linked polyubiquitination of the transcriptional effector RBPJ, stabilizing its chromatin association and potentiating transcriptional activation of Notch target genes. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of components of the PP4 phosphatase complex, including PP4C, PP4R2, PP4R3A and PP4R3B, thereby restraining PP4 phosphatase activity and ensuring proper DNA damage response signaling. Collaborates with CCDC6 to promote polyubiquitination and proteasomal degradation of the catalytic subunit PP2AC (By similarity). Recognizes ACAA2, promoting its ubiquitination and proteasomal degradation in hepatocytes, thereby attenuating fatty acid beta-oxidation; this activity is negatively regulated by CAND1, which prevents assembly of the SCF(FBXO42)-ACAA2 degradation complex (PubMed:37528093). {ECO:0000250|UniProtKB:Q6P3S6, ECO:0000269|PubMed:37528093}.
uniprot
proteins
mass_dalton
77777
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
37528093
uniprot
proteins
sequence_length
717
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6P3S6}.
uniprot
proteins