RAPGEF3
entrez
10411
canonical
uniprot
O95398
canonical
ensembl
ENSG00000079337
resolver
ensp
ENSP00000384521
resolver
ensp
ENSP00000395708
resolver
ensp
ENSP00000538791
resolver
ensp
ENSP00000671834
resolver
ensp
ENSP00000711370
resolver
genesymbol
RAPGEF3
resolver
genesymbol_syn
CGEF1
resolver
genesymbol_syn
EPAC
resolver
genesymbol_syn
EPAC1
resolver
hgnc
HGNC:16629
resolver
uniprot
A8K2G5
resolver
uniprot
E7EQC8
resolver
uniprot
O95634
resolver
uniprot
Q8WVN0
resolver
uniprot
Q99777
resolver
uniprot_entry
Q99777_HUMAN
resolver
uniprot_entry
RPGF3_HUMAN
resolver
uniprot_sec
A8K2G5
resolver
uniprot_sec
E7EQC8
resolver
uniprot_sec
O95634
resolver
uniprot_sec
Q8WVN0
resolver
amino_acid_sequence
MKVGWPGESCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVRTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. {ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:9853756}.
uniprot
proteins
mass_dalton
103751
uniprot
proteins
mutagenesis
MUTAGEN 315; /note="L->W: Abolishes activation of RAP1A."; /evidence="ECO:0000269|PubMed:12469113"; MUTAGEN 321; /note="R->K: Reduces activation of RAP1A."; /evidence="ECO:0000269|PubMed:9856955"; MUTAGEN 342; /note="F->A,T: Diminishes GEF activity dependence on cAMP concentration."; /evidence="ECO:0000269|PubMed:12469113"; MUTAGEN 412; /note="D->A: Abolishes interaction with PDE3B."; /evidence="ECO:0000269|PubMed:21393242"; MUTAGEN 415; /note="E->A: Abolishes interaction with PDE3B."; /evidence="ECO:0000269|PubMed:21393242"; MUTAGEN 417; /note="F->A: Abolishes interaction with PDE3B."; /evidence="ECO:0000269|PubMed:21393242"; MUTAGEN 420; /note="D->A: Abolishes interaction with PDE3B."; /evidence="ECO:0000269|PubMed:21393242"; MUTAGEN 421; /note="F->A: Abolishes interaction with PDE3B."; /evidence="ECO:0000269|PubMed:21393242
uniprot
proteins
pubmed
10777494
uniprot
proteins
pubmed
12469113
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
21393242
uniprot
proteins
pubmed
21840392
uniprot
proteins
pubmed
9853756
uniprot
proteins
pubmed
9856955
uniprot
proteins
sequence_length
923
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:10777494}.
uniprot
proteins