Sh2d1a
entrez
501502
canonical
uniprot
B2RZ59
canonical
ensembl
ENSRNOG00000080232
resolver
ensembl
ENSRNOG00055014907
resolver
ensembl
ENSRNOG00060021262
resolver
ensp
ENSRNOP00000098812
resolver
ensp
ENSRNOP00055020807
resolver
ensp
ENSRNOP00060030362
resolver
enst
ENSRNOT00000157081
resolver
enst
ENSRNOT00055025502
resolver
enst
ENSRNOT00060036851
resolver
genesymbol
Sh2d1a
resolver
uniprot_entry
SH21A_RAT
resolver
amino_acid_sequence
MDAVTVYHGKISREMGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSARSPQAPTGRRDSDICLKAP
uniprot
proteins
function
FUNCTION: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 (PubMed:16223723). {ECO:0000250|UniProtKB:O60880, ECO:0000250|UniProtKB:O88890, ECO:0000269|PubMed:16223723}.
uniprot
proteins
mass_dalton
13992
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16223723
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
126
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O88890}.
uniprot
proteins