Rtn4ip1
entrez
170728
canonical
uniprot
Q924D0
canonical
ensembl
ENSMUSG00000019864
resolver
ensp
ENSMUSP00000060940
resolver
ensp
ENSMUSP00000263262
resolver
enst
ENSMUST00000054418
resolver
genesymbol
Rtn4ip1
resolver
genesymbol_syn
Nimp
resolver
uniprot
A0A0R4J0S3
resolver
uniprot
Q8R1T0
resolver
uniprot_entry
A0A0R4J0S3_MOUSE
resolver
uniprot_entry
RT4I1_MOUSE
resolver
uniprot_sec
Q8R1T0
resolver
amino_acid_sequence
MGVLKTCVLRRSACAAACFWRRTVIPKPPFRGISTTSARSTVMPAWVIDKYGKNEVLRFTQNMMLPIIHYPNEVIIKVHAASVNPIDVNMRSGYGATALNMKRDPLHMKTKGEEFPLTLGRDVSGVVMECGLDVKYFQPGDEVWAAVPPWKQGTLSEFVVVSGNEVSHKPKSLTHTQAASLPYVALTAWSAINKVGGLSDKNCKGKRALILGASGGVGTFAIQVMKAWGAHVTAVCSKDASELVRKLGADEVIDYTLGSVEEQLKSLKLFDFILDNVGGSTETWALNFLKKWSGATYVTLVTPFLLNMDRLGVADGMLQTGVTVGTKALKHLWQGVHYRWAFFMASGPYLDEIAELVDAGKIRPVIERTFPFSEVPEAFLKVERGHARGKTVVNVV
uniprot
proteins
ec_number
1.6.5.-
uniprot
proteins
function
FUNCTION: NAD(P)H oxidoreductase involved in the ubiquinone biosynthetic pathway (PubMed:37884807). Required for the O-methyltransferase activity of COQ3 (By similarity). Able to catalyze the oxidoreduction of 3-demethylubiquinone into 3-demethylubiquinol in vitro (By similarity). However, it is unclear if 3-demethylubiquinone constitutes a substrate in vivo (By similarity). May also play a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve (PubMed:26593267). Appears to be a potent inhibitor of regeneration following spinal cord injury (PubMed:12067236). {ECO:0000250|UniProtKB:Q8WWV3, ECO:0000269|PubMed:12067236, ECO:0000269|PubMed:26593267, ECO:0000269|PubMed:37884807}.
uniprot
proteins
mass_dalton
43371
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000269|PubMed:37884807}.
uniprot
proteins
protein_family
Quinone oxidoreductase subfamily
uniprot
proteins
protein_family
Zinc-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
12067236
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26593267
uniprot
proteins
pubmed
37884807
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305|PubMed:12067236}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8WWV3}. Note=Mainly localizes to the mitochondrial matrix. Also colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria. {ECO:0000250|UniProtKB:Q8WWV3}.
uniprot
proteins