ARHGAP26
entrez
23092
canonical
uniprot
Q9UNA1
canonical
ensembl
ENSG00000145819
resolver
ensp
ENSP00000274498
resolver
ensp
ENSP00000495131
resolver
ensp
ENSP00000495827
resolver
ensp
ENSP00000697836
resolver
ensp
ENSP00000798179
resolver
ensp
ENSP00000798180
resolver
enst
ENST00000642734
resolver
genesymbol
ARHGAP26
resolver
genesymbol_syn
GRAF
resolver
genesymbol_syn
KIAA0621
resolver
genesymbol_syn
OPHN1L
resolver
hgnc
HGNC:17073
resolver
uniprot
A0A0S2Z536
resolver
uniprot
A0A2R8YGB3
resolver
uniprot
O75117
resolver
uniprot
Q5D035
resolver
uniprot
Q9BYS6
resolver
uniprot
Q9BYS7
resolver
uniprot
Q9UJ00
resolver
uniprot_entry
A0A0S2Z536_HUMAN
resolver
uniprot_entry
A0A2R8YGB3_HUMAN
resolver
uniprot_entry
RHG26_HUMAN
resolver
uniprot_sec
O75117
resolver
uniprot_sec
Q5D035
resolver
uniprot_sec
Q9BYS6
resolver
uniprot_sec
Q9BYS7
resolver
uniprot_sec
Q9UJ00
resolver
amino_acid_sequence
MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEKQEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVRSVAGFVWFSVAAVVLSLARSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVHEDSSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL
uniprot
proteins
disease_involvement
DISEASE: Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal translocation t(5;11)(q31;q23) with KMT2A/MLL1 has been found in leukemic cells from JMML patients, also carrying inactivating mutations on the second allele (PubMed:10908648). {ECO:0000269|PubMed:10908648}.
uniprot
proteins
function
FUNCTION: GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria (PubMed:38081847). Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V (PubMed:27512058). {ECO:0000269|PubMed:27512058, ECO:0000269|PubMed:38081847}.; FUNCTION: [Isoform 2]: Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins. {ECO:0000269|PubMed:32344433}.
uniprot
proteins
mass_dalton
92235
uniprot
proteins
mutagenesis
MUTAGEN 668; /note="S->A: Significantly reduced PINK1-mediated phosphorylation."; /evidence="ECO:0000269|PubMed:38081847"; MUTAGEN 671; /note="S->A: Significantly reduced PINK1-mediated phosphorylation."; /evidence="ECO:0000269|PubMed:38081847
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in a PINK1-dependent fashion promoting retrograde mitochondrial trafficking and clustering. {ECO:0000269|PubMed:38081847}.
uniprot
proteins
pubmed
10908648
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27512058
uniprot
proteins
pubmed
32344433
uniprot
proteins
pubmed
38081847
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
814
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Endosome membrane {ECO:0000269|PubMed:32344433}. Note=Colocalized with RAB8A, RAB8B and RAB10 on endosomal tubules. {ECO:0000269|PubMed:32344433}.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27512058, ECO:0000269|PubMed:38081847}. Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with actin stress fibers and cortical actin structures. {ECO:0000250}.
uniprot
proteins