Nae1
entrez
234664
canonical
uniprot
Q8VBW6
canonical
ensembl
ENSMUSG00000031878
resolver
ensp
ENSMUSP00000034349
resolver
ensp
ENSMUSP00000125456
resolver
enst
ENSMUST00000034349
resolver
enst
ENSMUST00000162466
resolver
genesymbol
Nae1
resolver
genesymbol_syn
Appbp1
resolver
uniprot
E0CZE0
resolver
uniprot
Q3UK27
resolver
uniprot
Q8CFL6
resolver
uniprot_entry
E0CZE0_MOUSE
resolver
uniprot_entry
Q3UK27_MOUSE
resolver
uniprot_entry
ULA1_MOUSE
resolver
uniprot_sec
Q8CFL6
resolver
activity_regulation
ACTIVITY REGULATION: Binding of TP53BP2 to the regulatory subunit NAE1 decreases neddylation activity. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MAQPGKILKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNLVSGEDAGNNFFLQKSSIGKNRAQAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTIVVATQLLESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHLQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYNETNGRIPKSYKEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPTFWILARALKEFVAKEGQGNLPVRGTIPDMIADSNKYIKLQNVYREKAKKDAAAVGNHVAKLLQSVGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTVNKDEIISSMDNPDNEIVLYLMLRAVDRFHKQHGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
uniprot
proteins
function
FUNCTION: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (By similarity). The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development. {ECO:0000250|UniProtKB:Q13564}.
uniprot
proteins
mass_dalton
60274
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein neddylation.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by TRIP12, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
ULA1 subfamily
uniprot
proteins
protein_family
Ubiquitin-activating E1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
534
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Note=Colocalizes with APP in lipid rafts. {ECO:0000250}.
uniprot
proteins