Ccdc47
entrez
303606
canonical
uniprot
Q5U2X6
canonical
ensembl
ENSRNOG00000009006
resolver
ensembl
ENSRNOG00055027940
resolver
ensembl
ENSRNOG00060012100
resolver
ensembl
ENSRNOG00065027710
resolver
ensp
ENSRNOP00000012533
resolver
ensp
ENSRNOP00055039779
resolver
ensp
ENSRNOP00060016176
resolver
ensp
ENSRNOP00065039161
resolver
enst
ENSRNOT00000012533
resolver
enst
ENSRNOT00055048380
resolver
enst
ENSRNOT00060020541
resolver
enst
ENSRNOT00065047750
resolver
genesymbol
Ccdc47
resolver
uniprot_entry
CCD47_RAT
resolver
amino_acid_sequence
MKAFCAFCVVLLVFGSVSEAKFDDFEDEEDIVEYDDNDFAEFEDVVEDSVTESPQRVINTEDDEDEATVELEGQDEGQEGDFEDADTQEGDTESEPYDDEEFEGYEDKPDTSSNKNKDPITIVDVPAHLQNSWESYYLEILMVTGLLAYIMNYIIGKNKNSRLAQAWFNSHRELLESNFTLVGDDGTNKEATSTGKLNQENEHIYNLWCSGRVCCEGMLIQLRFLKRQDLLNVLARMMRPVSDQVQIKVTMNDEDMDTYVFAVGTRKALLRLQKEMQDLSEFCSDKPKSGAKYGLPDSLAILSEMGEVTEGMMDTKMVHFLTHYADKIESVHFSDQFSGPKIMQEEGQPLKLPDTKRTLLFTFNVPGSGNTYPKDMEALLPLMNMVIYSIDKAKKFRLNREGKQKADKNRARVEENFLKLTHVQRQEAAQSRREEKKRAEKERIMNEEDPEKQRRLEEAALRREQKKLEKKQMKMKQIKVKAM
uniprot
proteins
function
FUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein. Within the PAT subcomplex, CCDC47 occludes the lateral gate of the SEC61 complex (By similarity). Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation) pathway (By similarity). Has an essential role in the maintenance of ER organization during embryogenesis (By similarity). {ECO:0000250|UniProtKB:A0A8I3P7X4, ECO:0000250|UniProtKB:Q96A33, ECO:0000250|UniProtKB:Q9D024}.
uniprot
proteins
mass_dalton
55733
uniprot
proteins
protein_family
CCDC47 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96A33}; Single-pass type I membrane protein {ECO:0000255}. Rough endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D024}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins