Traf5
entrez
22033
canonical
uniprot
P70191
canonical
ensembl
ENSMUSG00000026637
resolver
ensp
ENSMUSP00000141931
resolver
ensp
ENSMUSP00000285159
resolver
enst
ENSMUST00000195815
resolver
genesymbol
Traf5
resolver
uniprot
Q3UMS9
resolver
uniprot
Q61480
resolver
uniprot_entry
Q3UMS9_MOUSE
resolver
uniprot_entry
TRAF5_MOUSE
resolver
uniprot_sec
Q61480
resolver
amino_acid_sequence
MAHSEEQAAVPCAFIRQNSGNSISLDFEPDTEYQFVEQLEERYKCAFCHSVLHNPHQTGCGHRFCQQCIRSLRELNSVPICPVDKEVIKPQEVFKDNCCKREVLNLHVYCKNAPGCNARIILGRFQDHLQHCSFQAVPCPNESCREAMLRKDVKEHLSAYCRFREEKCLYCKRDIVVTNLQDHEENSCPAYPVSCPNRCVQTIPRARVNEHLTVCPEAEQDCPFKHYGCTVKGKRGNLLEHERAALQDHMLLVLEKNYQLEQRISDLYQSLEQKESKIQQLAETVKKFEKELKQFTQMFGRNGTFLSNVQALTSHTDKSAWLEAQVRQLLQIVNQQPSRLDLRSLVDAVDSVKQRITQLEASDQRLVLLEGETSKHDAHINIHKAQLNKNEERFKQLEGACYSGKLIWKVTDYRVKKREAVEGHTVSVFSQPFYTSRCGYRLCARAYLNGDGSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNHIVETFKADPNSSSFKRPDGEMNIASGCPRFVSHSTLENSKNTYIKDDTLFLKVAVDLTDLEDL
uniprot
proteins
function
FUNCTION: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. {ECO:0000269|PubMed:15121867}.
uniprot
proteins
mass_dalton
64145
uniprot
proteins
mutagenesis
MUTAGEN 318; /note="K->R: Abolished ubiquitination by the SCF(FBXL2) complex."; /evidence="ECO:0000269|PubMed:23542741"; MUTAGEN 408; /note="W->A: Decreased interaction with FBXL2."; /evidence="ECO:0000269|PubMed:23542741
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated at Lys-318 by the SCF(FBXL2) complex, leading to its degradation by the proteasome. {ECO:0000269|PubMed:23542741}.
uniprot
proteins
protein_family
A subfamily
uniprot
proteins
protein_family
TNF receptor-associated factor family
uniprot
proteins
pubmed
15121867
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23542741
uniprot
proteins
pubmed
8663299
uniprot
proteins
pubmed
8790348
uniprot
proteins
sequence_length
558
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytosol.
uniprot
proteins