SLC23A1
entrez
9963
canonical
uniprot
Q9UHI7
canonical
ensembl
ENSG00000170482
resolver
ensp
ENSP00000302701
resolver
ensp
ENSP00000302851
resolver
genesymbol
SLC23A1
resolver
genesymbol_syn
SVCT1
resolver
genesymbol_syn
YSPL3
resolver
hgnc
HGNC:10974
resolver
uniprot
O95191
resolver
uniprot
Q8WWB6
resolver
uniprot
Q9UGH4
resolver
uniprot
Q9UI39
resolver
uniprot_entry
S23A1_HUMAN
resolver
uniprot_sec
O95191
resolver
uniprot_sec
Q8WWB6
resolver
uniprot_sec
Q9UGH4
resolver
uniprot_sec
Q9UI39
resolver
amino_acid_sequence
MRAQEDLEGRTQHETTRDPSTPLPTEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGHDQHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKAILALERWKCPPEEEIYGNWSLPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALLNYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIILFSQYLRNLTFLLPVYRWGKGLTLLRIQIFKMFPIMLAIMTVWLLCYVLTLTDVLPTDPKAYGFQARTDARGDIMAIAPWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAAIMLVLGTIGKFTALFASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLESNPGAINTGILEVDQILIVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSDMSSSLKSYDFPIGMGIVKRITFLKYIPICPVFKGFSSSSKDQIAIPEDTPENTETASVCTKV
uniprot
proteins
function
FUNCTION: Sodium:ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed:10556483, PubMed:10556521, PubMed:10631088, PubMed:36749388). Has retained some ancestral activity toward nucleobases such as urate, an oxidized purine. Low-affinity high-capacity sodium:urate cotransporter, may regulate serum urate levels by serving as a renal urate re-absorber (PubMed:36749388). {ECO:0000269|PubMed:10556483, ECO:0000269|PubMed:10556521, ECO:0000269|PubMed:10631088, ECO:0000269|PubMed:36749388}.; FUNCTION: [Isoform 2]: Inactive transporter. {ECO:0000269|PubMed:10556483}.
uniprot
proteins
mass_dalton
64815
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:10556521}.
uniprot
proteins
protein_family
Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family
uniprot
proteins
pubmed
10556483
uniprot
proteins
pubmed
10556521
uniprot
proteins
pubmed
10631088
uniprot
proteins
pubmed
11396616
uniprot
proteins
pubmed
11584081
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19379732
uniprot
proteins
pubmed
36749388
uniprot
proteins
pubmed
9804989
uniprot
proteins
sequence_length
598
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10631088, ECO:0000269|PubMed:19379732, ECO:0000269|PubMed:36749388}; Multi-pass membrane protein {ECO:0000269|PubMed:19379732}.
uniprot
proteins
transmembrane_region
TRANSMEM 53..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 208..225; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 251..271; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 313..333; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 359..379; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 403..423; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 427..447; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 458..478; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 491..511; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins