PSMD10
entrez
5716
canonical
uniprot
O75832
canonical
ensembl
ENSG00000101843
resolver
ensp
ENSP00000217958
resolver
ensp
ENSP00000354906
resolver
genesymbol
PSMD10
resolver
hgnc
HGNC:9555
resolver
uniprot
Q5U0B2
resolver
uniprot
Q8IZK9
resolver
uniprot_entry
PSD10_HUMAN
resolver
uniprot_sec
Q5U0B2
resolver
uniprot_sec
Q8IZK9
resolver
amino_acid_sequence
MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG
uniprot
proteins
function
FUNCTION: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.; FUNCTION: Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.
uniprot
proteins
mass_dalton
24428
uniprot
proteins
mutagenesis
MUTAGEN 182; /note="E->A: Abolishes interaction with RB1."; /evidence="ECO:0000269|PubMed:10613832
uniprot
proteins
pubmed
10613832
uniprot
proteins
pubmed
11779854
uniprot
proteins
pubmed
11900540
uniprot
proteins
pubmed
14573599
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14997555
uniprot
proteins
pubmed
15379554
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16023600
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
18040287
uniprot
proteins
pubmed
19490896
uniprot
proteins
pubmed
19729910
uniprot
proteins
pubmed
20628200
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
9714768
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18040287}. Nucleus {ECO:0000269|PubMed:18040287}.
uniprot
proteins