Rasgrp1
entrez
19419
canonical
uniprot
Q9Z1S3
canonical
ensembl
ENSMUSG00000027347
resolver
ensp
ENSMUSP00000099593
resolver
enst
ENSMUST00000102534
resolver
genesymbol
Rasgrp1
resolver
genesymbol_syn
Rasgrp
resolver
uniprot
Q3URH0
resolver
uniprot
Q3V401
resolver
uniprot
Q8BQP6
resolver
uniprot_entry
GRP1_MOUSE
resolver
uniprot_sec
Q3URH0
resolver
uniprot_sec
Q3V401
resolver
uniprot_sec
Q8BQP6
resolver
activity_regulation
ACTIVITY REGULATION: Autoinhibited. Activated by diacylglycerol and calcium binding, which induces a conformational change releasing the autoinhibitory state. Regulated by DGKA. Regulated by DGKZ. Regulated by PLC gamma and F-actin polymerization (By similarity). {ECO:0000250|UniProtKB:O95267}.
uniprot
proteins
amino_acid_sequence
MGTLGKAREAPRKPCHGSRAGPKARLEAKSTNSPLPAQPSLAQITQFRMMVSLGHLAKGASLDDLIDSCIQSFDADGNLCRNNQLLQVMLTMHRIIISSAELLQKVMNLYKDALEKNSPGVCLKICYFVRYWITEFWIMFKMDASLTSTMEEFQDLVKANGEETHCHLIDTTQINSRDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLEDGKVNVQKLLALYNHINELVQLQEMAPPLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRIKSPAISTENISSVVPMSTLCPLGTKDLLHAPEEGSFIFQNGEIVDHSEESKDRTIMLLGVSSQKISVRLKRTVAHKSTQTESFPWVGGETTPGHFVLSSPRKSAQGALYVHSPASPCPSPALVRKRAFVKWENKESLIKPKPELHLRLRTYQELEQEINTLKADNDALKIQLKYAQKKIESLQLGKSNHVLAQMDHGDSA
uniprot
proteins
function
FUNCTION: Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (By similarity). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (PubMed:17190838). May also function in differentiation of other cell types. Proto-oncogene, which promotes T-cell lymphomagenesis when its expression is deregulated (PubMed:15829980, PubMed:17210708). {ECO:0000250|UniProtKB:O95267, ECO:0000269|PubMed:11017103, ECO:0000269|PubMed:12433368, ECO:0000269|PubMed:12538669, ECO:0000269|PubMed:12845332, ECO:0000269|PubMed:14532295, ECO:0000269|PubMed:14970203, ECO:0000269|PubMed:15829980, ECO:0000269|PubMed:16301621, ECO:0000269|PubMed:16849453, ECO:0000269|PubMed:17190838, ECO:0000269|PubMed:17210708, ECO:0000269|PubMed:9819387}.
uniprot
proteins
mass_dalton
90304
uniprot
proteins
mutagenesis
MUTAGEN 271; /note="R->E: Loss of function and transforming activity."; /evidence="ECO:0000269|PubMed:14970203, ECO:0000269|PubMed:9819387
uniprot
proteins
protein_family
RASGRP family
uniprot
proteins
pubmed
10087292
uniprot
proteins
pubmed
11017103
uniprot
proteins
pubmed
12433368
uniprot
proteins
pubmed
12538669
uniprot
proteins
pubmed
12845332
uniprot
proteins
pubmed
12932358
uniprot
proteins
pubmed
14532295
uniprot
proteins
pubmed
14970203
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15829980
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16301621
uniprot
proteins
pubmed
16849453
uniprot
proteins
pubmed
17190838
uniprot
proteins
pubmed
17210708
uniprot
proteins
pubmed
17523924
uniprot
proteins
pubmed
17567957
uniprot
proteins
pubmed
17675473
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22808526
uniprot
proteins
pubmed
9819387
uniprot
proteins
sequence_length
795
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent (By similarity). Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity). {ECO:0000250}.
uniprot
proteins