HMOX2
entrez
3163
canonical
uniprot
P30519
canonical
ensembl
ENSG00000103415
resolver
ensembl
ENSG00000277424
resolver
ensp
ENSP00000381595
resolver
ensp
ENSP00000385100
resolver
ensp
ENSP00000391637
resolver
ensp
ENSP00000394103
resolver
ensp
ENSP00000459214
resolver
ensp
ENSP00000460926
resolver
ensp
ENSP00000477572
resolver
ensp
ENSP00000480515
resolver
ensp
ENSP00000484423
resolver
ensp
ENSP00000484467
resolver
ensp
ENSP00000575953
resolver
ensp
ENSP00000575954
resolver
enst
ENST00000613539
resolver
enst
ENST00000617111
resolver
genesymbol
HMOX2
resolver
genesymbol_syn
HO2
resolver
hgnc
HGNC:5014
resolver
uniprot
A0A087WT44
resolver
uniprot
A8MT35
resolver
uniprot
B3KSE0
resolver
uniprot
D3DUD5
resolver
uniprot
I3L430
resolver
uniprot
O60605
resolver
uniprot_entry
A0A087WT44_HUMAN
resolver
uniprot_entry
B3KSE0_HUMAN
resolver
uniprot_entry
HMOX2_HUMAN
resolver
uniprot_sec
A8MT35
resolver
uniprot_sec
D3DUD5
resolver
uniprot_sec
I3L430
resolver
uniprot_sec
O60605
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by metalloporphyrins such as Sn- and Zn-protoporphyrins. {ECO:0000269|PubMed:1575508}.
uniprot
proteins
amino_acid_sequence
MSAEVETSEGVDESEKKNSGALEKENQMRMADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMERNKDHPAFAPLYFPMELHRKEALTKDMEYFFGENWEEQVQCPKAAQKYVERIHYIGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFENVDNAQQFKQLYRARMNALDLNMKTKERIVEEANKAFEYNMQIFNELDQAGSTLARETLEDGFPVHDGKGDMRKCPFYAAEQDKGALEGSSCPFRTAMAVLRKPSLQFILAAGVALAAGLLAWYYM
uniprot
proteins
ec_number
1.14.14.18
uniprot
proteins
function
FUNCTION: [Heme oxygenase 2]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:1575508, ECO:0000269|PubMed:7890772}.; FUNCTION: [Heme oxygenase 2 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:7890772}.
uniprot
proteins
mass_dalton
36033
uniprot
proteins
mutagenesis
MUTAGEN 265; /note="C->R: Abolished S-nitrosylation; when associated with R-282."; /evidence="ECO:0000269|PubMed:38056462"; MUTAGEN 282; /note="C->R: Abolished S-nitrosylation; when associated with R-265."; /evidence="ECO:0000269|PubMed:38056462
uniprot
proteins
post_translational_modification
PTM: A soluble form arises by proteolytic removal of the membrane anchor. {ECO:0000305|PubMed:7890772}.; PTM: S-nitrosylated by BLVRB. {ECO:0000269|PubMed:38056462}.
uniprot
proteins
protein_family
Heme oxygenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
1575508
uniprot
proteins
pubmed
17965015
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
38056462
uniprot
proteins
pubmed
7890772
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305|PubMed:7890772}; Single-pass type IV membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000250|UniProtKB:P09601}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P09601}; Single-pass type IV membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000250|UniProtKB:P09601}.
uniprot
proteins
transmembrane_region
TRANSMEM 296..316; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins