Dpy30
entrez
66310
canonical
uniprot
Q99LT0
canonical
ensembl
ENSMUSG00000024067
resolver
ensp
ENSMUSP00000108190
resolver
ensp
ENSMUSP00000126702
resolver
ensp
ENSMUSP00000156795
resolver
ensp
ENSMUSP00000156830
resolver
enst
ENSMUST00000112571
resolver
enst
ENSMUST00000164832
resolver
enst
ENSMUST00000232687
resolver
enst
ENSMUST00000233581
resolver
genesymbol
Dpy30
resolver
uniprot_entry
DPY30_MOUSE
resolver
amino_acid_sequence
MESEQMLEGQTQVAENPHSEYGLTDSVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN
uniprot
proteins
function
FUNCTION: As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and histone H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. May also play an indirect or direct role in endosomal transport. {ECO:0000269|PubMed:21335234}.
uniprot
proteins
mass_dalton
11213
uniprot
proteins
protein_family
Dpy-30 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21335234
uniprot
proteins
sequence_length
99
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21335234}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=Associated with chromatin at regions enriched in histone H3 trimethylated at 'Lys-4'. Highly enriched in gene promoter regions and 5' UTRs, but not in downstream regions of genes or 3' UTRs.
uniprot
proteins