RAET1G
entrez
353091
canonical
uniprot
Q6H3X3
canonical
ensembl
ENSG00000203722
resolver
ensp
ENSP00000356329
resolver
ensp
ENSP00000356330
resolver
ensp
ENSP00000735043
resolver
genesymbol
RAET1G
resolver
genesymbol_syn
ULBP5
resolver
hgnc
HGNC:16795
resolver
uniprot
Q6H3X2
resolver
uniprot_entry
ULBP5_HUMAN
resolver
uniprot_sec
Q6H3X2
resolver
amino_acid_sequence
MAAAASPAFLLRLPLLLLLSSWCRTGLADPHSLCYDITVIPKFRPGPRWCAVQGQVDEKTFLHYDCGSKTVTPVSPLGKKLNVTTAWKAQNPVLREVVDILTEQLLDIQLENYIPKEPLTLQARMSCEQKAEGHGSGSWQLSFDGQIFLLFDSENRMWTTVHPGARKMKEKWENDKDMTMSFHYISMGDCTGWLEDFLMGMDSTLEPSAGAPPTMSSGTAQPRATATTLILCCLLIMCLLICSRHSLTQSHGHHPQSLQPPPHPPLLHPTWLLRRVLWSDSYQIAKRPLSGGHVTRVTLPIIGDDSHSLPCPLALYTINNGAARYSEPLQVSIS
uniprot
proteins
function
FUNCTION: [Isoform 1]: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:18544572, ECO:0000269|PubMed:19658097}.; FUNCTION: [Isoform 3]: Down-regulates the expression of KLRK1 and stimulates natural killer cells to secrete IFNG. {ECO:0000269|PubMed:18544572}.; FUNCTION: [Isoform 2]: Stimulates natural killer cells to secrete IFNG. {ECO:0000269|PubMed:18544572}.
uniprot
proteins
mass_dalton
37106
uniprot
proteins
mutagenesis
MUTAGEN 217; /note="S->P: Reduced cell surface expression."; /evidence="ECO:0000269|PubMed:20304922
uniprot
proteins
post_translational_modification
PTM: The functional form is cleaved C-terminally of the GPI-anchor and yields a 28 kDa protein. {ECO:0000269|PubMed:20304922}.
uniprot
proteins
protein_family
MHC class I family
uniprot
proteins
pubmed
15240696
uniprot
proteins
pubmed
18544572
uniprot
proteins
pubmed
19223974
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19658097
uniprot
proteins
pubmed
20304922
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:19223974, ECO:0000269|PubMed:20304922}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:20304922}. Endoplasmic reticulum {ECO:0000269|PubMed:19223974, ECO:0000269|PubMed:20304922}. Note=Mainly found intracellularly. {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:19223974, ECO:0000269|PubMed:20304922}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:19223974}.
uniprot
proteins
transmembrane_region
TRANSMEM 224..243; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins