Calhm2
entrez
294019
canonical
uniprot
Q5RJQ8
canonical
ensembl
ENSRNOG00000020325
resolver
ensembl
ENSRNOG00055003849
resolver
ensembl
ENSRNOG00060030309
resolver
ensembl
ENSRNOG00065031220
resolver
ensp
ENSRNOP00000027526
resolver
ensp
ENSRNOP00055004607
resolver
ensp
ENSRNOP00060043765
resolver
ensp
ENSRNOP00065044278
resolver
enst
ENSRNOT00000027526
resolver
enst
ENSRNOT00055006085
resolver
enst
ENSRNOT00060052625
resolver
enst
ENSRNOT00065053838
resolver
genesymbol
Calhm2
resolver
genesymbol_syn
Fam26b
resolver
uniprot_entry
CAHM2_RAT
resolver
amino_acid_sequence
MAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLTAIGVPALALFLIGVILNNHTWNLVAECQYRRAKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAGDEGFPPDHATEILARFPCGEGPANLSGFREEVSRRLKYESQLFGWLLIGVVAILVFLTKCFKHYCSPLSYRQEAYWAQYRTNEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELVTKFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLTGNGTAPDNVEMALLTV
uniprot
proteins
function
FUNCTION: Pore-forming subunit of Ca(2+) homeostasis modulator channels. Mediates ATP release from astrocytes and ATP-induced Ca(2+) influx in microglia thus regulating neuronal ATP and Ca(2+) homeostasis, synaptic transmission and neuroinflammatory response. May form intercellular gap junctions. The gating mechanism remains unknown. {ECO:0000250|UniProtKB:Q8VEC4, ECO:0000250|UniProtKB:Q9HA72}.
uniprot
proteins
mass_dalton
35931
uniprot
proteins
protein_family
CALHM family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8VEC4}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..43; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:Q9HA72"; TRANSMEM 53..76; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:Q9HA72"; TRANSMEM 102..132; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:Q9HA72"; TRANSMEM 180..206; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:Q9HA72
uniprot
proteins