Emc2
entrez
66736
canonical
uniprot
Q9CRD2
canonical
ensembl
ENSMUSG00000022337
resolver
ensp
ENSMUSP00000022962
resolver
ensp
ENSMUSP00000297207
resolver
ensp
ENSMUSP00000297208
resolver
enst
ENSMUST00000022962
resolver
genesymbol
Emc2
resolver
genesymbol_syn
Kiaa0103
resolver
genesymbol_syn
Ttc35
resolver
genesymbol_syn
mKIAA0103
resolver
uniprot
Q6A0D1
resolver
uniprot
Q925K1
resolver
uniprot_entry
EMC2_MOUSE
resolver
uniprot_entry
Q6A0D1_MOUSE
resolver
uniprot_sec
Q925K1
resolver
amino_acid_sequence
MAKVTERYDVTWEEMRDKMRKWREENSRNSEQIMEVGEELINDYASKLGDDIWIIYEQVMIAALDYGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQEDPTNTAARKRKIAIRKAQGKTVEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPHNHLYCQQYAEVKYTQGGLENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKMKKDNIKYASWAANQINRAYQFAGRSKKETKYSLKAVEDMLETLQITQS
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. {ECO:0000250|UniProtKB:Q15006}.
uniprot
proteins
mass_dalton
34935
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated when soluble in the cytoplasm, leading to its degradation by the proteasome. Interaction with EMC2 prevents its ubiquitination and degradation. {ECO:0000250|UniProtKB:Q15006}.
uniprot
proteins
protein_family
EMC2 family
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
11593002
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15006}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15006}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15006}. Note=May also localize to the nuclear envelope. {ECO:0000269|PubMed:11593002}.
uniprot
proteins