AKR1B15
entrez
441282
canonical
uniprot
C9JRZ8
canonical
ensembl
ENSG00000227471
resolver
ensp
ENSP00000389289
resolver
ensp
ENSP00000397009
resolver
ensp
ENSP00000498877
resolver
genesymbol
AKR1B15
resolver
hgnc
HGNC:37281
resolver
uniprot
C9J3V2
resolver
uniprot_entry
AK1BF_HUMAN
resolver
uniprot_sec
C9J3V2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the inhibitor JF0064. {ECO:0000269|PubMed:26222439}.
uniprot
proteins
amino_acid_sequence
MATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQEKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGDDFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFDFKEFSHLEDFPFDAEY
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
ec_number
1.1.1.216
uniprot
proteins
ec_number
1.1.1.300
uniprot
proteins
ec_number
1.1.1.54
uniprot
proteins
ec_number
1.1.1.64
uniprot
proteins
function
FUNCTION: [Isoform 1]: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:21276782, PubMed:26222439). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439). {ECO:0000269|PubMed:21276782, ECO:0000269|PubMed:25577493, ECO:0000269|PubMed:26222439}.; FUNCTION: [Isoform 2]: No oxidoreductase activity observed with the tested substrates. {ECO:0000269|PubMed:25577493}.
uniprot
proteins
mass_dalton
36537
uniprot
proteins
protein_family
Aldo/keto reductase family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
21276782
uniprot
proteins
pubmed
25577493
uniprot
proteins
pubmed
26222439
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:25577493}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:25577493}.
uniprot
proteins