Prx
entrez
19153
canonical
uniprot
O55103
canonical
ensembl
ENSMUSG00000053198
resolver
ensp
ENSMUSP00000096241
resolver
ensp
ENSMUSP00000103992
resolver
ensp
ENSMUSP00000158878
resolver
enst
ENSMUST00000098644
resolver
enst
ENSMUST00000238936
resolver
genesymbol
Prx
resolver
uniprot
E9QQ57
resolver
uniprot
O55104
resolver
uniprot_entry
E9QQ57_MOUSE
resolver
uniprot_entry
PRAX_MOUSE
resolver
uniprot_sec
O55104
resolver
amino_acid_sequence
MEARSRSAEELRRAELVEIIVETEAQTGVSGFNVAGGGKEGIFVRELREDSPAAKSLSLQEGDQLLSARVFFENFKYEDALRLLQCAEPYKVSFCLKRTVPTGDLALRPGTVSGYEMKGPRAKVAKLNIQSLAPVKKKKMVTGALGTPADLAPVDVEFSFPKFSRLRRGLKAEAVKGPVPAAPARRRLQLPRLRVREVAEEAQVARMAAAAPPPRKAKAEAEAATGAGFTAPQIELVGPRLPSAEVGVPQVSVPKGTPSTEAASGFALHLPTLGLGAPAAPAVEPPATGIQVPQVELPTLPSLPTLPTLPCLDTQEGAAVVKVPTLDVAAPSMGVDLALPGAEVEAQGEVPEVALKMPRLSFPRFGIRGKEATEAKVVKGSPEAKAKGPRLRMPTFGLSLLEPRPSGPEAVAESKLKLPTLKMPSFGIGVAGPEVKAPTGPEVKLPKVPEVKLPKVPEAAIPDVQLPEVQLPKMSDMKLPKIPEMVVPDVRLPEVQLPKVPEMKVPEMKLPKWPEMAVPDVHLPDVQLPKVPEMKLPKVPEMAVPDVHLPDVQLPKVPEMKLPEMKLPKVPEMAVPDVRLPEVQLPKVSEVKLPKMPEMAVPDVHLPELQLPKMSEVKLPKMPEMAVPDVRLPEVQLPKVSEMKLPKMPEMTMPDIRLPEVQLPKVPDIKLPEMKLPEIKLPKVPDMAVPDVPLPELQLPKVSDIRLPEMQVSQVPEVQLPKMPEMKLSKVPEVQRKSAGAEQAKGTEFSFKLPKMTMPKLGKVGKPGEASIEVPDKLMTLPCLQPEVGTEASHVGVPSLSLPSVELDLPGALGLEGQVQEAVPGKVEKPEGPRVAVGVGEVGFRVPSVEIVTPQLPTVEVEKEQLEMVEMKVKPSSKFSLPKFGLSGPKAVKGEVEGPGRATKLKVSKFTISLPKARAGTEAEAKGAGEAGLLPALDLSIPQLSLDAQLPSGKVEVADSKPKSSRFALPKFGVKGRDSEADVLVAGEAELEGKGWGWDGKVKMPKLKMPSFGLSRGKEAETQDGRVSPGEKLEAIAGQLKIPAVELVTPGAQETEKVTSGVKPSGLQVSTTGQVVAEGQESVQRVSTLGISLPQVELASFGEAGPEIVAPSAEGTAGSRVQVPQVMLELPGTQVAGGDLLVGEGIFKMPTVTVPQLELDVGLGHEAQAGEAAKSEGGIKLKLPTLGTGSRGEGVEPQGPEAQRTFHLSLPDVELTSPVSSHAEYQVVEGDGDGGHKLKVRLPLFGLAKAKEGIEVGEKVKSPKLRLPRVGFSQSESVSGEGSPSPEEEEEGSGEGASSRRGRVRVRLPRVGLASPSKVSKGQEGDATSKSPVGEKSPKFRFPRVSLSPKARSGSRDREEGGFRVRLPSVGFSETAVPGSTRIEGTQAAAI
uniprot
proteins
function
FUNCTION: Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells (PubMed:11430802, PubMed:21745462, PubMed:22764250). Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli (PubMed:10839370). Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions (PubMed:15356632). Required for normal remyelination after nerve injury (PubMed:10839370). Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses (PubMed:15356632, PubMed:23022068). Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions (PubMed:15356632, PubMed:23022068). Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves (PubMed:22764250, PubMed:23022068). Recruits DRP2 to the Schwann cell plasma membrane (PubMed:11430802, PubMed:22764250, PubMed:23022068). Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology (PubMed:21745462). {ECO:0000269|PubMed:10839370, ECO:0000269|PubMed:11430802, ECO:0000269|PubMed:15356632, ECO:0000269|PubMed:22764250, ECO:0000269|PubMed:23022068}.
uniprot
proteins
mass_dalton
147688
uniprot
proteins
protein_family
Periaxin family
uniprot
proteins
pubmed
10671475
uniprot
proteins
pubmed
10839370
uniprot
proteins
pubmed
11430802
uniprot
proteins
pubmed
15356632
uniprot
proteins
pubmed
18205176
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21745462
uniprot
proteins
pubmed
22764250
uniprot
proteins
pubmed
23022068
uniprot
proteins
pubmed
9488714
uniprot
proteins
sequence_length
1391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21745462}. Cell junction {ECO:0000269|PubMed:21745462}. Note=Colocalizes with ACTB at tricellular junctions between eye lens fiber cells. {ECO:0000269|PubMed:21745462}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:9488714}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Nucleus {ECO:0000269|PubMed:10671475}. Cytoplasm {ECO:0000250|UniProtKB:Q9BXM0}. Note=Detected in the Schwann cell nucleus prior to the onset of myelination (PubMed:10671475). Detected in Schwann cells at periaxonal myelin membranes. Associated with the cell membrane during myelination (PubMed:9488714). {ECO:0000269|PubMed:10671475, ECO:0000269|PubMed:9488714}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:10671475, ECO:0000269|PubMed:9488714}.
uniprot
proteins