CTSK
entrez
1513
canonical
uniprot
P43235
canonical
ensembl
ENSG00000143387
resolver
ensp
ENSP00000271651
resolver
ensp
ENSP00000503723
resolver
ensp
ENSP00000504176
resolver
ensp
ENSP00000632287
resolver
ensp
ENSP00000632289
resolver
enst
ENST00000271651
resolver
enst
ENST00000676824
resolver
enst
ENST00000676966
resolver
enst
ENST00000962228
resolver
enst
ENST00000962230
resolver
genesymbol
CTSK
resolver
genesymbol_syn
CTSO
resolver
genesymbol_syn
CTSO2
resolver
hgnc
HGNC:2536
resolver
uniprot
Q6FHS6
resolver
uniprot_entry
CATK_HUMAN
resolver
uniprot_sec
Q6FHS6
resolver
amino_acid_sequence
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
uniprot
proteins
disease_involvement
DISEASE: Pycnodysostosis (PKND) [MIM:265800]: A rare autosomal recessive bone disorder characterized by deformity of the skull, maxilla and phalanges, osteosclerosis, and fragility of bone. {ECO:0000269|PubMed:10491211, ECO:0000269|PubMed:10878663, ECO:0000269|PubMed:22822386, ECO:0000269|PubMed:25731711, ECO:0000269|PubMed:8703060, ECO:0000269|PubMed:9529353}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.22.38
uniprot
proteins
function
FUNCTION: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042). {ECO:0000269|PubMed:11082042}.
uniprot
proteins
mass_dalton
36966
uniprot
proteins
protein_family
Peptidase C1 family
uniprot
proteins
pubmed
10048321
uniprot
proteins
pubmed
10491211
uniprot
proteins
pubmed
10878663
uniprot
proteins
pubmed
11082042
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
22822386
uniprot
proteins
pubmed
25731711
uniprot
proteins
pubmed
7576232
uniprot
proteins
pubmed
7805878
uniprot
proteins
pubmed
7818555
uniprot
proteins
pubmed
8585423
uniprot
proteins
pubmed
8703060
uniprot
proteins
pubmed
9033587
uniprot
proteins
pubmed
9405598
uniprot
proteins
pubmed
9529353
uniprot
proteins
pubmed
9893980
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:11082042}. Secreted {ECO:0000269|PubMed:11082042}. Apical cell membrane {ECO:0000269|PubMed:11082042}; Peripheral membrane protein {ECO:0000269|PubMed:11082042}; Extracellular side {ECO:0000269|PubMed:11082042}. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells. {ECO:0000269|PubMed:11082042}.
uniprot
proteins