Selenot
entrez
365802
canonical
uniprot
Q1H5H1
canonical
ensembl
ENSRNOG00000013507
resolver
ensembl
ENSRNOG00055018352
resolver
ensembl
ENSRNOG00060004707
resolver
ensembl
ENSRNOG00065023908
resolver
ensp
ENSRNOP00000018248
resolver
ensp
ENSRNOP00055025108
resolver
ensp
ENSRNOP00060005911
resolver
ensp
ENSRNOP00065033483
resolver
enst
ENSRNOT00055031145
resolver
enst
ENSRNOT00060007867
resolver
enst
ENSRNOT00065041002
resolver
genesymbol
Selenot
resolver
genesymbol_syn
Selt
resolver
uniprot_entry
SELT_RAT
resolver
amino_acid_sequence
MRLLLLLLVAASAVVRSEASANLGGVPSKRLKMQYATGPLLKFQICVSUGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYRHIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS
uniprot
proteins
ec_number
1.8.1.9
uniprot
proteins
function
FUNCTION: Selenoprotein with thioredoxin reductase-like oxidoreductase activity (PubMed:26866473). Protects dopaminergic neurons against oxidative stress and cell death (By similarity). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (PubMed:18198219). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (PubMed:26779623). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity). {ECO:0000250|UniProtKB:P62341, ECO:0000250|UniProtKB:P62342, ECO:0000269|PubMed:18198219, ECO:0000269|PubMed:26779623, ECO:0000269|PubMed:26866473}.
uniprot
proteins
mass_dalton
22292
uniprot
proteins
mutagenesis
MUTAGEN 46..49; /note="CVSU->SVSS: Highly reduces thioredoxin reductase activity."; /evidence="ECO:0000269|PubMed:26779623"; MUTAGEN 49; /note="U->A: Abolishes regulation of calcium mobilization."; /evidence="ECO:0000269|PubMed:18198219
uniprot
proteins
post_translational_modification
PTM: May contain a selenide-sulfide bond between Cys-46 and Sec-49. This bond is speculated to serve as redox-active pair (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
SelWTH family
uniprot
proteins
protein_family
Selenoprotein T subfamily
uniprot
proteins
pubmed
18198219
uniprot
proteins
pubmed
26779623
uniprot
proteins
pubmed
26866473
uniprot
proteins
sequence_length
195
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18198219}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 85..103; /note="Helical"; /evidence="ECO:0000255, ECO:0000305|PubMed:18198219
uniprot
proteins