ARL1
entrez
400
canonical
uniprot
P40616
canonical
ensembl
ENSG00000120805
resolver
ensp
ENSP00000261636
resolver
ensp
ENSP00000439590
resolver
enst
ENST00000539055
resolver
genesymbol
ARL1
resolver
hgnc
HGNC:692
resolver
uniprot
B4DWW1
resolver
uniprot
B4DZG7
resolver
uniprot
F6QVZ4
resolver
uniprot
P80417
resolver
uniprot
Q53XB1
resolver
uniprot_entry
ARL1_HUMAN
resolver
uniprot_entry
B4DZG7_HUMAN
resolver
uniprot_entry
F6QVZ4_HUMAN
resolver
uniprot_sec
B4DWW1
resolver
uniprot_sec
P80417
resolver
uniprot_sec
Q53XB1
resolver
amino_acid_sequence
MGGFFSSIFSSLFGTREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVETVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAVIYVVDSCDRDRIGISKSELVAMLEEEELRKAILVVFANKQDMEQAMTSSEMANSLGLPALKDRKWQIFKTSATKGTGLDEAMEWLVETLKSRQ
uniprot
proteins
function
FUNCTION: GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex (PubMed:21239483, PubMed:22679020, PubMed:27373159, PubMed:27436755, PubMed:9624189, PubMed:12972563). Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:12972563, ECO:0000269|PubMed:21239483, ECO:0000269|PubMed:22679020, ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:27373159, ECO:0000269|PubMed:27436755, ECO:0000269|PubMed:9624189}.
uniprot
proteins
mass_dalton
20418
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="T->N: Loss of interaction with ARFIP1 and ARFIP2."; /evidence="ECO:0000269|PubMed:21239483"; MUTAGEN 71; /note="Q->L: Altered Golgi structure with an engorged lumen. Interacts with ARFIP2, GOLGA4, RGPD8, SCOC and UNC119."; /evidence="ECO:0000269|PubMed:11303027
uniprot
proteins
protein_family
Arf family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11303027
uniprot
proteins
pubmed
12972563
uniprot
proteins
pubmed
14580338
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21239483
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22679020
uniprot
proteins
pubmed
22981988
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27373159
uniprot
proteins
pubmed
27436755
uniprot
proteins
pubmed
7814376
uniprot
proteins
pubmed
9624189
uniprot
proteins
sequence_length
181
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:11303027, ECO:0000269|PubMed:12972563}; Peripheral membrane protein {ECO:0000269|PubMed:11303027}; Cytoplasmic side {ECO:0000269|PubMed:11303027}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21239483, ECO:0000269|PubMed:27373159, ECO:0000269|PubMed:27436755}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
uniprot
proteins