CD177
entrez
57126
canonical
uniprot
Q8N6Q3
canonical
ensembl
ENSG00000204936
resolver
ensp
ENSP00000479536
resolver
ensp
ENSP00000786427
resolver
enst
ENST00000618265
resolver
genesymbol
CD177
resolver
genesymbol_syn
NB1
resolver
genesymbol_syn
PRV1
resolver
hgnc
HGNC:30072
resolver
uniprot
A0A087WVM2
resolver
uniprot
Q711Q2
resolver
uniprot
Q8NCV9
resolver
uniprot
Q96QH1
resolver
uniprot
Q9HDA5
resolver
uniprot_entry
A0A087WVM2_HUMAN
resolver
uniprot_entry
CD177_HUMAN
resolver
uniprot_sec
Q711Q2
resolver
uniprot_sec
Q8NCV9
resolver
uniprot_sec
Q96QH1
resolver
uniprot_sec
Q9HDA5
resolver
amino_acid_sequence
MSAVLLLALLGFILPLPGVQALLCQFGTVQHVWKVSDLPRQWTPKNTSCDSGLGCQDTLMLIESGPQVSLVLSKGCTEAKDQEPRVTEHRMGPGLSLISYTFVCRQEDFCNNLVNSLPLWAPQPPADPGSLRCPVCLSMEGCLEGTTEEICPKGTTHCYDGLLRLRGGGIFSNLRVQGCMPQPGCNLLNGTQEIGPVGMTENCNRKDFLTCHRGTTIMTHGNLAQEPTDWTTSNTEMCEVGQVCQETLLLLDVGLTSTLVGTKGCSTVGAQNSQKTTIHSAPPGVLVASYTHFCSSDLCNSASSSSVLLNSLPPQAAPVPGDRQCPTCVQPLGTCSSGSPRMTCPRGATHCYDGYIHLSGGGLSTKMSIQGCVAQPSSFLLNHTRQIGIFSAREKRDVQPPASQHEGGGAEGLESLTWGVGLALAPALWWGVVCPSC
uniprot
proteins
function
FUNCTION: In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369). {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23202369, ECO:0000269|PubMed:23461681, ECO:0000269|PubMed:28807980}.
uniprot
proteins
mass_dalton
46363
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:11465086, ECO:0000269|PubMed:12239154}.; PTM: A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). {ECO:0000269|PubMed:12239154, ECO:0000269|PubMed:18462208}.
uniprot
proteins
pubmed
10753836
uniprot
proteins
pubmed
11465086
uniprot
proteins
pubmed
12010833
uniprot
proteins
pubmed
12239154
uniprot
proteins
pubmed
12377969
uniprot
proteins
pubmed
12623849
uniprot
proteins
pubmed
12675722
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14692971
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17244676
uniprot
proteins
pubmed
17580308
uniprot
proteins
pubmed
18462208
uniprot
proteins
pubmed
21193407
uniprot
proteins
pubmed
23202369
uniprot
proteins
pubmed
23461681
uniprot
proteins
pubmed
24926686
uniprot
proteins
pubmed
27227454
uniprot
proteins
pubmed
28240246
uniprot
proteins
pubmed
28807980
uniprot
proteins
sequence_length
437
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12239154, ECO:0000269|PubMed:12675722, ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:24926686, ECO:0000269|PubMed:27227454, ECO:0000269|PubMed:28240246, ECO:0000269|PubMed:28807980}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12239154, ECO:0000269|PubMed:17244676}. Membrane raft {ECO:0000269|PubMed:21193407}; Lipid-anchor, GPI-like-anchor {ECO:0000269|PubMed:12239154, ECO:0000269|PubMed:17244676}. Secreted {ECO:0000269|PubMed:12239154, ECO:0000269|PubMed:18462208}. Cytoplasmic granule membrane {ECO:0000269|PubMed:18462208}. Cell projection, lamellipodium {ECO:0000269|PubMed:28807980}. Note=Cell surface expression on neutrophils is increased upon TNF, fMLP or CXCL8/IL8-mediated stimulation (PubMed:17244676, PubMed:17580308). In neutrophils, stored predominantly in secondary and tertiary granules (PubMed:18462208). Can also be shedded from the cell membrane (PubMed:12239154, PubMed:18462208). Localizes to lamellar protrusions in spreading neutrophils (PubMed:28807980). {ECO:0000269|PubMed:12239154, ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:28807980}.
uniprot
proteins