Abcc4
entrez
239273
canonical
uniprot
E9Q236
canonical
ensembl
ENSMUSG00000032849
resolver
ensp
ENSMUSP00000042186
resolver
ensp
ENSMUSP00000129677
resolver
ensp
ENSMUSP00000180649
resolver
enst
ENSMUST00000166646
resolver
genesymbol
Abcc4
resolver
genesymbol_syn
Mrp4
resolver
uniprot
A0A1C9IC75
resolver
uniprot
B7ZWC5
resolver
uniprot
E9Q467
resolver
uniprot
Q3TZN9
resolver
uniprot_entry
E9Q467_MOUSE
resolver
uniprot_entry
MRP4_MOUSE
resolver
uniprot_sec
A0A1C9IC75
resolver
uniprot_sec
B7ZWC5
resolver
uniprot_sec
Q3TZN9
resolver
amino_acid_sequence
MLPVHTEVKPNPLQDANLCSRVFFWWLNPLFKTGHKRRLEEDDMFSVLPEDRSKHLGEELQRYWDKELLRAKKDSRKPSLTKAIIKCYWKSYLILGIFTLIEEGTRVVQPLFLGKIIEYFEKYDPDDSVALHTAYGYAAVLSMCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIAVTVLLWVEIGISCLAGLAVLVILLPLQSCIGKLFSSLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLIANLRKKEISKILGSSYLRGMNMASFFIANKVILFVTFTSYVLLGNEITASHVFVAMTLYGAVRLTVTLFFPSAIERGSEAIVSIRRIKNFLLLDELPQRKAHVPSDGKAIVHVQDFTAFWDKALDSPTLQGLSFIARPGELLAVVGPVGAGKSSLLSAVLGELPPASGLVSVHGRIAYVSQQPWVFSGTVRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVGKHLFQLCICQALHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFGSLLKKENEEAEPSTAPGTPTLRKRTFSEASIWSQQSSRPSLKDGAPEGQDAENTQAVQPEESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNMVGQVFYVLQDWWLSHWANKQGALNNTRNANGNITETLDLSWYLGIYAGLTAVTVLFGIARSLLVFYILVNASQTLHNRMFESILKAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSVVFLVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAIFVIVVAFGSLVLAKTLNAGQVGLALSYALTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEKEAPWECKKRPPPGWPHEGVIVFDNVNFTYSLDGPLVLKHLTALIKSREKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWRALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKNNRILIIDEATANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNPESLFYKMVQQLGKGEAAALTETAKQVYFRRNYPDITFTSPAVMNTSNGQPSALTIFETAL
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
ec_number
7.6.2.3
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells (By similarity). Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (By similarity). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (By similarity). Mediates the cotransport of bile acids with reduced glutathione (GSH) (By similarity). May contribute to hepatic, intestinal and renal excretion of steroid conjugates. Selectively transports steroid glucuronates and sulfates. Mediates the efflux of estrogens glucuronated at C-16 and C-17 positions, but has no transporter activity toward estrogens glucuronated at C-3. Has high affinity for dehydroepiandrosterone-3-sulfate and can also transport testosterone-17-sulfate, but has no transporter activity toward androsterone and etiocholanolone sulfate conjugates. Does not transport estrone 3-sulfate (By similarity). Displays low affinity and high transport velocity for folates (By similarity). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotic molecules (By similarity). Confers resistance to anticancer agents such as methotrexate (By similarity). {ECO:0000250|UniProtKB:O15439}.
uniprot
proteins
mass_dalton
148888
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; leading to substrate-selective effects on its transport activity. {ECO:0000250|UniProtKB:O15439}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCC family
uniprot
proteins
protein_family
Conjugate transporter (TC 3.A.1.208) subfamily
uniprot
proteins
pubmed
12883481
uniprot
proteins
pubmed
15314169
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17210706
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27613143
uniprot
proteins
sequence_length
1325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15314169}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O15439}. Apical cell membrane {ECO:0000269|PubMed:15314169}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O15439}. Note=Its localization to the basolateral or apical membranes is tissue-dependent. {ECO:0000269|PubMed:15314169}.
uniprot
proteins
transmembrane_region
TRANSMEM 89..131; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 137..176; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 211..244; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 247..274; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 319..352; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 357..390; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 720..755; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 769..803; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 840..871; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 874..892; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 950..984; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:O15439"; TRANSMEM 985..1014; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:O15439
uniprot
proteins