Ltc4s
entrez
17001
canonical
uniprot
Q60860
canonical
ensembl
ENSMUSG00000020377
resolver
ensp
ENSMUSP00000098823
resolver
ensp
ENSMUSP00000099833
resolver
ensp
ENSMUSP00000325007
resolver
enst
ENSMUST00000101265
resolver
enst
ENSMUST00000102772
resolver
genesymbol
Ltc4s
resolver
uniprot
F6VT13
resolver
uniprot
Q5SVR7
resolver
uniprot
Q8K355
resolver
uniprot
Q9QVS1
resolver
uniprot_entry
F6VT13_MOUSE
resolver
uniprot_entry
LTC4S_MOUSE
resolver
uniprot_entry
Q8K355_MOUSE
resolver
uniprot_sec
Q5SVR7
resolver
uniprot_sec
Q9QVS1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by MK886. {ECO:0000250|UniProtKB:Q16873}.
uniprot
proteins
amino_acid_sequence
MKDEVALLATVTLVGVLLQAYFSLQVISARRAFHVSPPLTSGPPEFERVFRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLFYLFARLRYFQGYARSAQLRLTPLYASARALWLLVAMAALGLLVHFLPGTLRTALFRWLQMLLPMA
uniprot
proteins
ec_number
2.5.1.-
uniprot
proteins
ec_number
4.4.1.20
uniprot
proteins
function
FUNCTION: Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:11319240, PubMed:8706658). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (By similarity). {ECO:0000250|UniProtKB:Q16873, ECO:0000269|PubMed:11319240, ECO:0000269|PubMed:8706658}.
uniprot
proteins
mass_dalton
16814
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; leukotriene C4 biosynthesis. {ECO:0000250|UniProtKB:Q16873}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-36 by RPS6KB1 inhibits the leukotriene-C4 synthase activity. {ECO:0000250|UniProtKB:Q16873}.
uniprot
proteins
protein_family
MAPEG family
uniprot
proteins
pubmed
11319240
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7766706
uniprot
proteins
pubmed
8706658
uniprot
proteins
pubmed
9342232
uniprot
proteins
sequence_length
150
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000250|UniProtKB:Q16873}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16873}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q16873}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16873}. Nucleus membrane {ECO:0000250|UniProtKB:Q16873}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16873}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q16873"; TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q16873"; TRANSMEM 74..94; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q16873"; TRANSMEM 105..124; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q16873
uniprot
proteins