Q91ZP6
uniprot
Q91ZP6
canonical
amino_acid_sequence
RRSASDAELSAGAEGATGSEAAPPGDLGGRTRGGGRGSAAAAATTSTREAEGAERRGDTPARKPDPEAGRMDHHQLGTGRYQVLHNEEDNSESSAVEQPSTSSLAAPTVEAAASAPALDPDSPPPYSSITVEAPTTSDTDVYSEFYPVPPPYSVATSLPTYDEAEKAKAAALAAAAADAPQRNQEEDCTPRDDFSDVEQLRVGNDGIFMLAFFMAFIFNWLGFCLSFCITNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNYLKVRNMSESMAAAHRTRYFFLL
uniprot
proteins
function
FUNCTION: Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (By similarity). May modulate EGFR signaling (By similarity). Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (PubMed:27088444). {ECO:0000250|UniProtKB:Q9NV92, ECO:0000269|PubMed:12050153, ECO:0000269|PubMed:15252135, ECO:0000269|PubMed:27088444}.
uniprot
proteins
mass_dalton
33638
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by NEDD4 and NEDD4L; which does not affect turnover (Probable). Also ubiquitinated by ITCH (By similarity). {ECO:0000250, ECO:0000305}.; PTM: Undergoes transient tyrosine-phosphorylation following EGF stimulation, most probably catalyzed by SRC. Phosphorylation on Tyr-126, Tyr-146 and Tyr-152 are dependent on the phosphorylation on Tyr-142. Also phosphorylated by LYN and FYN (By similarity). {ECO:0000250|UniProtKB:Q9NV92}.
uniprot
proteins
pubmed
12050153
uniprot
proteins
pubmed
15252135
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
27088444
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:12050153}; Multi-pass membrane protein {ECO:0000269|PubMed:12050153}. Golgi apparatus membrane {ECO:0000269|PubMed:15252135}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:15252135}; Multi-pass membrane protein {ECO:0000269|PubMed:15252135}.
uniprot
proteins
transmembrane_region
TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 263..283; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins