Orai1
entrez
304496
canonical
uniprot
Q5M848
canonical
genesymbol
Orai1
resolver
genesymbol_syn
Cracm1
resolver
genesymbol_syn
Tmem142a
resolver
uniprot_entry
ORAI1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Oxidation at Cys-196 leads to inactivation of channel activity. {ECO:0000250|UniProtKB:Q96D31}.
uniprot
proteins
amino_acid_sequence
MHPEPAPPPNNSNPELPLSGGSSTSGSRRSRRRSGDGEPTGAPPLPPPPAVSYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDTDHDYPPGLLIVFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKRQAGQPSPTKPPTEPAVVVANSSNNGGITPGEAAAIASTAIMVPCGLVFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHSLTPGTHYA
uniprot
proteins
function
FUNCTION: Pore-forming subunit of two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (By similarity). Assembles with ORAI2 and ORAI3 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. Activates NFATC2/NFAT1 and NFATC3/NFAT4-mediated transcriptional responses. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription (By similarity). Assembles with ORAI3 to form channels that mediate store-independent Ca(2+) influx in response to inflammatory metabolites arachidonate or its derivative leukotriene C4, termed ARC and LRC channels respectively (By similarity). Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion (By similarity). {ECO:0000250|UniProtKB:Q8BWG9, ECO:0000250|UniProtKB:Q96D31}.
uniprot
proteins
mass_dalton
33040
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. N-glycosylation inhibits channel activity in T cells. {ECO:0000250|UniProtKB:Q96D31}.; PTM: Ubiquitinated. {ECO:0000250|UniProtKB:Q96D31}.; PTM: Cys-195 is oxidated, leading to inactivation of channel activity. {ECO:0000250|UniProtKB:Q96D31}.
uniprot
proteins
protein_family
Orai family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23109337
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96D31}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96D31}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8BWG9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96D31}. Note=Colocalizes with STIM1 in membrane punctate structures at ER-PM junctions. {ECO:0000250|UniProtKB:Q96D31}.
uniprot
proteins
transmembrane_region
TRANSMEM 89..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 121..141; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 175..195; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins