Neu2
entrez
23956
canonical
uniprot
Q9JMH3
canonical
ensembl
ENSMUSG00000079434
resolver
ensp
ENSMUSP00000065439
resolver
ensp
ENSMUSP00000126509
resolver
ensp
ENSMUSP00000127913
resolver
ensp
ENSMUSP00000131409
resolver
ensp
ENSMUSP00000132513
resolver
ensp
ENSMUSP00000203071
resolver
ensp
ENSMUSP00000203074
resolver
enst
ENSMUST00000070898
resolver
enst
ENSMUST00000164128
resolver
enst
ENSMUST00000165109
resolver
enst
ENSMUST00000166259
resolver
enst
ENSMUST00000172222
resolver
genesymbol
Neu2
resolver
uniprot
A0A0R4J224
resolver
uniprot
C0KJU9
resolver
uniprot
E9Q0I0
resolver
uniprot
Q0VGI4
resolver
uniprot
Q3ULV6
resolver
uniprot
Q99NA3
resolver
uniprot_entry
A0A0R4J224_MOUSE
resolver
uniprot_entry
C0KJU9_MOUSE
resolver
uniprot_entry
E9Q0I0_MOUSE
resolver
uniprot_entry
NEUR2_MOUSE
resolver
uniprot_entry
Q0VGI4_MOUSE
resolver
uniprot_entry
Q3ULV6_MOUSE
resolver
uniprot_sec
Q99NA3
resolver
amino_acid_sequence
MATCPVLQKETLFRTGVHAYRIPALLYLKKQKTLLAFAEKRASKTDEHAELIVLRRGSYNEATNRVKWQPEEVVTQAQLEGHRSMNPCPLYDKQTKTLFLFFIAVPGRVSEHHQLHTKVNVTRLCCVSSTDHGRTWSPIQDLTETTIGSTHQEWATFAVGPGHCLQLRNPAGSLLVPAYAYRKLHPAQKPTPFAFCFISLDHGHTWKLGNFVAENSLECQVAEVGTGAQRMVYLNARSFLGARVQAQSPNDGLDFQDNRVVSKLVEPPHGCHGSVVAFHNPISKPHALDTWLLYTHPTDSRNRTNLGVYLNQMPLDPTAWSEPTLLAMGICAYSDLQNMGQGPDGSPQFGCLYESGNYEEIIFLIFTLKQAFPTVFDAQ
uniprot
proteins
ec_number
3.2.1.18
uniprot
proteins
function
FUNCTION: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides (PubMed:10713120). Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate (By similarity). Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles (PubMed:10713120). Hydrolyzes exclusively monomeric GM1 ganglioside, but has no activity toward the miscellar form (By similarity). Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages (By similarity). Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward isomer alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues (By similarity). {ECO:0000250|UniProtKB:Q9Y3R4, ECO:0000269|PubMed:10713120}.
uniprot
proteins
mass_dalton
42403
uniprot
proteins
protein_family
Glycosyl hydrolase 33 family
uniprot
proteins
pubmed
10329453
uniprot
proteins
pubmed
10713120
uniprot
proteins
pubmed
11500029
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Y3R4}.
uniprot
proteins