Hopx
entrez
171160
canonical
uniprot
Q78ZR5
canonical
ensembl
ENSRNOG00000024689
resolver
ensembl
ENSRNOG00065020152
resolver
ensp
ENSRNOP00000044357
resolver
ensp
ENSRNOP00065027217
resolver
enst
ENSRNOT00000049774
resolver
enst
ENSRNOT00065033999
resolver
genesymbol
Hopx
resolver
genesymbol_syn
Giig15b
resolver
genesymbol_syn
Hod
resolver
genesymbol_syn
Hop
resolver
genesymbol_syn
Ob1
resolver
uniprot
Q8R4G4
resolver
uniprot_entry
HOP_RAT
resolver
uniprot_sec
Q8R4G4
resolver
amino_acid_sequence
MSAQTASGPTEDQVEILEYNFNKVNKHPDPTTLCLIAAEAGLTEEQTQKWFKQRLAEWRRSEGLPSECRSVTD
uniprot
proteins
function
FUNCTION: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding. {ECO:0000250|UniProtKB:Q8R1H0, ECO:0000250|UniProtKB:Q9BPY8}.
uniprot
proteins
mass_dalton
8282
uniprot
proteins
pubmed
12297046
uniprot
proteins
pubmed
14516659
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
73
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12297046}.
uniprot
proteins