Corin
entrez
289596
canonical
uniprot
Q80YN4
canonical
ensembl
ENSRNOG00000002302
resolver
ensp
ENSRNOP00000061602
resolver
ensp
ENSRNOP00000104752
resolver
enst
ENSRNOT00000064128
resolver
enst
ENSRNOT00000133364
resolver
genesymbol
Corin
resolver
uniprot
A0ABK0LP57
resolver
uniprot
D3ZN44
resolver
uniprot
F1LS60
resolver
uniprot
J3QTE2
resolver
uniprot_entry
A0ABK0LP57_RAT
resolver
uniprot_entry
CORIN_RAT
resolver
uniprot_entry
J3QTE2_RAT
resolver
uniprot_sec
D3ZN44
resolver
uniprot_sec
F1LS60
resolver
amino_acid_sequence
MGRVSFNVRVSSVRRARCSCPGRCYLSCRVPPTTALHALNGFGRAGVLGETAGGTVGLGPSGTRGFLSGSKFQASGSLKDCFGAPPAPDVLRADSSVGEGCPQKLVTANLLRFLLLVLIPCICALIVLLAILLSFVGTLKKVYFKSNDSEPLVTDGEVRVPGVIHVNRYENTGAPSMPPSQSIPAWTPRAPSLEDQSHGNTSTCVNITHRQCQILPYHSTLAPLLPIVKNMDTEKFLKFFTYLHRLGCYQHILLFGCSLAFPKCIVDGDDRHGLLPCRSFCEAAKEGCESVLGMVNSSWPDSLRCSQFRYHTENNSDASRICFSLQQEHGKQSLCGGGESFLCTSGLCISKKLQCNGYNDCDDWSDEAHCNCSEDLFHCGTGKCLHHSLVCDGYDDCGDLSDEQNCDCNLTKEHRCGDGRCIAAEWVCDGDHDCVDKSDEVNCSCPSQGLVECRSGQCIPSTFQCDGDEDCKDGSDEENCSDRPTPCPGGDRGCLDSSCVESCAGSSLCDSDSSLSNCSHCEPITLELCMNLPYNLTHYPNYLGHRTQKEASISWESALFPALVQTNCYKYLMFFACTILVPKCDVNTGQRVPPCRLLCEHSKERCESVLGIVGLQWPEDTDCSQFPEQSSDNQTCLLPNEDVEECSPSHFKCRSGRCVLGSRRCDGQADCDDDSDEENCGCKERDLWECPLNKQCLKHTLICDGFPDCSDSMDEKNCSFCQDDELECANHECVPRDLWCDGWTDCSDSSDEWGCVTLSKNGNSSSFLTVHRSARDHHVCADGWQETLSQLACRQMGLGEPSVTELVQGQEGQQWLRLHSSWENLNGSTLQELLVHRRSCPSGSEISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGREDADVWKVVFGINNLDHPSGFMQTRFVKTILLHPRYSRAVVDYDISVVELSDDINETSYVRPVCLPSPREFLEPDTYCYITGWGHMGNKMPFKLQEGEVRIIPLEQCQSYFDMKTITNRMICAGYESGTVDSCMIDSGGPLVCERPGGQWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVDWIERQIYIQTFLQKKSQG
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) processing (PubMed:17660514). Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation (By similarity). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (By similarity). Also acts as a regulator of sodium reabsorption in kidney (PubMed:20613715). May also process pro-NPPB the B-type natriuretic peptide (By similarity). {ECO:0000250|UniProtKB:Q9Y5Q5, ECO:0000250|UniProtKB:Q9Z319, ECO:0000269|PubMed:17660514, ECO:0000269|PubMed:20613715}.
uniprot
proteins
mass_dalton
122757
uniprot
proteins
mutagenesis
MUTAGEN 866; /note="R->A: Impairs proteolytic processing and activation."; /evidence="ECO:0000269|PubMed:17660514"; MUTAGEN 968; /note="N->S: Prevents proteolytic processing and activation; when associated with S-1087."; /evidence="ECO:0000269|PubMed:17660514"; MUTAGEN 1087; /note="N->S: Prevents proteolytic processing and activation; when associated with S-968."; /evidence="ECO:0000269|PubMed:17660514
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; required for processing and activation. {ECO:0000269|PubMed:17660514}.; PTM: Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment. Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1 (Probable). {ECO:0000305|PubMed:17660514}.; PTM: A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment (Probable). {ECO:0000305}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15155264
uniprot
proteins
pubmed
17660514
uniprot
proteins
pubmed
20613715
uniprot
proteins
sequence_length
1111
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle.; SUBCELLULAR LOCATION: [Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]: Secreted {ECO:0000250}. Note=Soluble form produced following cleavage by ADAM10. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 113..133; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins