Htr2c
entrez
15560
canonical
uniprot
P34968
canonical
ensembl
ENSMUSG00000041380
resolver
ensp
ENSMUSP00000043936
resolver
ensp
ENSMUSP00000094021
resolver
ensp
ENSMUSP00000138772
resolver
enst
ENSMUST00000036303
resolver
enst
ENSMUST00000096299
resolver
enst
ENSMUST00000156697
resolver
genesymbol
Htr2c
resolver
genesymbol_syn
5ht1c
resolver
genesymbol_syn
Htr1c
resolver
uniprot
B1ATN5
resolver
uniprot
Q5WRU6
resolver
uniprot
Q8BZI5
resolver
uniprot
S4R2T0
resolver
uniprot_entry
5HT2C_MOUSE
resolver
uniprot_entry
Q8BZI5_MOUSE
resolver
uniprot_entry
S4R2T0_MOUSE
resolver
uniprot_sec
B1ATN5
resolver
uniprot_sec
Q5WRU6
resolver
amino_acid_sequence
MVNLGTAVRSLLVHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELRNISLNFLKCCCKKGDEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVVRKANDTEPGIEMQVENLELPVNPSNVVSERISSV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:17596444). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). HTR2C is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (By similarity). Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelanocortin neurons and the release of CRH that then regulates the release of corticosterone (PubMed:19038216, PubMed:21037584, PubMed:21835345). Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress (PubMed:17451451, PubMed:21048120, PubMed:7700379). Plays a role in insulin sensitivity and glucose homeostasis (PubMed:21037584, PubMed:9771748). {ECO:0000250|UniProtKB:P28335, ECO:0000269|PubMed:17451451, ECO:0000269|PubMed:17596444, ECO:0000269|PubMed:19038216, ECO:0000269|PubMed:21037584, ECO:0000269|PubMed:21048120, ECO:0000269|PubMed:21835345, ECO:0000269|PubMed:7700379, ECO:0000269|PubMed:9771748}.
uniprot
proteins
mass_dalton
51929
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1381232
uniprot
proteins
pubmed
1661811
uniprot
proteins
pubmed
16914526
uniprot
proteins
pubmed
17451451
uniprot
proteins
pubmed
17596444
uniprot
proteins
pubmed
19038216
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19501602
uniprot
proteins
pubmed
21037584
uniprot
proteins
pubmed
21048120
uniprot
proteins
pubmed
21835345
uniprot
proteins
pubmed
7700379
uniprot
proteins
pubmed
9771748
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P28335}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 57..81; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P28335"; TRANSMEM 88..112; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P28335"; TRANSMEM 130..152; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P28335"; TRANSMEM 169..190; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P28335"; TRANSMEM 215..237; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P28335"; TRANSMEM 313..337; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P28335"; TRANSMEM 349..371; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P28335
uniprot
proteins