Epha5
entrez
13839
canonical
uniprot
Q60629
canonical
ensembl
ENSMUSG00000029245
resolver
ensp
ENSMUSP00000060646
resolver
ensp
ENSMUSP00000109025
resolver
ensp
ENSMUSP00000109026
resolver
ensp
ENSMUSP00000109028
resolver
ensp
ENSMUSP00000109030
resolver
ensp
ENSMUSP00000272781
resolver
ensp
ENSMUSP00000272782
resolver
ensp
ENSMUSP00000272783
resolver
ensp
ENSMUSP00000272786
resolver
ensp
ENSMUSP00000272787
resolver
ensp
ENSMUSP00000272789
resolver
ensp
ENSMUSP00000272795
resolver
ensp
ENSMUSP00000272804
resolver
ensp
ENSMUSP00000272812
resolver
enst
ENSMUST00000053733
resolver
enst
ENSMUST00000113398
resolver
enst
ENSMUST00000113399
resolver
enst
ENSMUST00000113401
resolver
enst
ENSMUST00000113403
resolver
genesymbol
Epha5
resolver
genesymbol_syn
Bsk
resolver
genesymbol_syn
Ehk1
resolver
uniprot
E9PUQ0
resolver
uniprot
E9PUQ2
resolver
uniprot
E9PUQ4
resolver
uniprot
E9QPV2
resolver
uniprot
F6X443
resolver
uniprot
Q6PFV6
resolver
uniprot_entry
E9PUQ0_MOUSE
resolver
uniprot_entry
E9PUQ2_MOUSE
resolver
uniprot_entry
E9PUQ4_MOUSE
resolver
uniprot_entry
EPHA5_MOUSE
resolver
uniprot_entry
F6X443_MOUSE
resolver
uniprot_entry
Q6PFV6_MOUSE
resolver
uniprot_sec
E9QPV2
resolver
amino_acid_sequence
MRGSGPRGAGHRRTQGRGGGDDTPRVPASLAGCYSAPLKGPLWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDDENGRSIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAIFPDTITGADSSQLLEVSGSCVNHSVTDDPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETSITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVSVAASNDQSQIPIIAVSVTVGVILLAVMIGFLLSGSCCDCGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSSSDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKFDEIVNMLDKLIRNPSSLKTLVNASSRVSTLLAEHGSLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMSSLQEMKVQMVNGMVPV
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. {ECO:0000269|PubMed:12124402, ECO:0000269|PubMed:17448994}.
uniprot
proteins
mass_dalton
97056
uniprot
proteins
mutagenesis
MUTAGEN 817; /note="K->A: Strongly reduced binding affinity for SAMD5 SAM domain."; /evidence="ECO:0000269|PubMed:29749928"; MUTAGEN 852; /note="V->P: Strongly reduced binding affinity for SAMD5 SAM domain."; /evidence="ECO:0000269|PubMed:29749928"; MUTAGEN 856; /note="K->A: Strongly reduced binding affinity for SAMD5 SAM domain."; /evidence="ECO:0000269|PubMed:29749928"; MUTAGEN 857; /note="K->A: Strongly reduced binding affinity for SAMD5 SAM domain."; /evidence="ECO:0000269|PubMed:29749928
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation is stimulated by the ligand EFNA5. Dephosphorylation upon stimulation by glucose, inhibits EPHA5 forward signaling and results in insulin secretion. {ECO:0000269|PubMed:12124402, ECO:0000269|PubMed:17448994}.
uniprot
proteins
protein_family
Ephrin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
12124402
uniprot
proteins
pubmed
17448994
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27446912
uniprot
proteins
pubmed
29749928
uniprot
proteins
pubmed
8145300
uniprot
proteins
sequence_length
876
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P54757}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P54757}. Cell projection, dendrite {ECO:0000250|UniProtKB:P54756}.
uniprot
proteins
transmembrane_region
TRANSMEM 413..433; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins