Alkal1
entrez
620393
canonical
uniprot
J3QPP8
canonical
ensembl
ENSMUSG00000087247
resolver
ensp
ENSMUSP00000137420
resolver
enst
ENSMUST00000133144
resolver
genesymbol
Alkal1
resolver
genesymbol_syn
Fam150a
resolver
uniprot_entry
ALKL1_MOUSE
resolver
amino_acid_sequence
MWLTKPSTPVSALLLLALALSPPGTQGRPQRSLAARVAELRPELFLPVTGTRLPPRASRSTEIFPRDLTLKDKFIKHFTGPVTFSAECSKHFHRLYHNTRDCSTPAYYKRCARLLTRLAVSPLCSQT
uniprot
proteins
function
FUNCTION: Cytokine that acts as a physiological ligand for receptor tyrosine kinase LTK, leading to its activation. Monomeric ALKAL1 binds to LTK, leading to LTK homodimerization and activation. In contrast to ALKAL2, does not act as a potent physiological ligand for ALK. {ECO:0000250|UniProtKB:Q6UXT8}.
uniprot
proteins
mass_dalton
14246
uniprot
proteins
protein_family
ALKAL family
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
127
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6UX46}. Cell membrane {ECO:0000250|UniProtKB:Q6UXT8}. Note=Following interaction with receptor tyrosine kinase LTK, associates with the cell membrane, membrane-binding is required to activate LTK. {ECO:0000250|UniProtKB:Q6UX46}.
uniprot
proteins