DCAF12
entrez
25853
canonical
uniprot
Q5T6F0
canonical
ensembl
ENSG00000198876
resolver
ensp
ENSP00000355114
resolver
enst
ENST00000361264
resolver
genesymbol
DCAF12
resolver
genesymbol_syn
KIAA1892
resolver
genesymbol_syn
TCC52
resolver
genesymbol_syn
WDR40A
resolver
hgnc
HGNC:19911
resolver
uniprot
A8KA70
resolver
uniprot
D3DRL6
resolver
uniprot
Q5T6E9
resolver
uniprot
Q5T6F1
resolver
uniprot
Q6P3V0
resolver
uniprot
Q7L4F8
resolver
uniprot
Q96PZ5
resolver
uniprot
Q9NXA9
resolver
uniprot
Q9UFJ1
resolver
uniprot_entry
DCA12_HUMAN
resolver
uniprot_sec
A8KA70
resolver
uniprot_sec
D3DRL6
resolver
uniprot_sec
Q5T6E9
resolver
uniprot_sec
Q5T6F1
resolver
uniprot_sec
Q6P3V0
resolver
uniprot_sec
Q7L4F8
resolver
uniprot_sec
Q96PZ5
resolver
uniprot_sec
Q9NXA9
resolver
uniprot_sec
Q9UFJ1
resolver
amino_acid_sequence
MARKVVSRKRKAPASPGAGSDAQGPQFGWDHSLHKRKRLPPVKRSLVYYLKNREVRLQNETSYSRVLHGYAAQQLPSLLKEREFHLGTLNKVFASQWLNHRQVVCGTKCNTLFVVDVQTSQITKIPILKDREPGGVTQQGCGIHAIELNPSRTLLATGGDNPNSLAIYRLPTLDPVCVGDDGHKDWIFSIAWISDTMAVSGSRDGSMGLWEVTDDVLTKSDARHNVSRVPVYAHITHKALKDIPKEDTNPDNCKVRALAFNNKNKELGAVSLDGYFHLWKAENTLSKLLSTKLPYCRENVCLAYGSEWSVYAVGSQAHVSFLDPRQPSYNVKSVCSRERGSGIRSVSFYEHIITVGTGQGSLLFYDIRAQRFLEERLSACYGSKPRLAGENLKLTTGKGWLNHDETWRNYFSDIDFFPNAVYTHCYDSSGTKLFVAGGPLPSGLHGNYAGLWS
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:16949367, PubMed:16964240, PubMed:29779948). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948). The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6 and CCT5, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:31267705). Ubiquitination of MAGEA3, MAGEA6 by DCX(DCAF12) complex is required for starvation-induced autophagy (PubMed:31267705). Also directly recognizes the C-terminal glutamate-leucine (Glu-Leu) degron as an alternative degron in proteins such as MOV10, leading to their ubiquitination and degradation. Controls the protein level of MOV10 during spermatogenesis and in T cells, especially after their activation (PubMed:34065512). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:31267705, ECO:0000269|PubMed:34065512}.
uniprot
proteins
mass_dalton
50517
uniprot
proteins
mutagenesis
MUTAGEN 368; /note="R->A: Reduces association with DDB1."; /evidence="ECO:0000269|PubMed:16949367
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:31267705}.
uniprot
proteins
protein_family
WD repeat DCAF12 family
uniprot
proteins
pubmed
11572484
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16949367
uniprot
proteins
pubmed
16964240
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18957058
uniprot
proteins
pubmed
19966799
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29779948
uniprot
proteins
pubmed
31267705
uniprot
proteins
pubmed
34065512
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18957058, ECO:0000269|PubMed:34065512}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18957058}. Nucleus {ECO:0000269|PubMed:34065512}.
uniprot
proteins