Cbx4
entrez
12418
canonical
uniprot
O55187
canonical
ensembl
ENSMUSG00000039989
resolver
ensp
ENSMUSP00000026665
resolver
genesymbol
Cbx4
resolver
genesymbol_syn
Pc2
resolver
uniprot
Q149G5
resolver
uniprot
Q149G6
resolver
uniprot_entry
CBX4_MOUSE
resolver
uniprot_sec
Q149G5
resolver
uniprot_sec
Q149G6
resolver
amino_acid_sequence
MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSADNRAKLELGTQGKGQGHQYELNSKKHHQYQPHSKERSGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEAPSPTCPDLGTKSHPPDKWAHGAAAKGYLGAVKPLGGGAGAPGKGSEKGPPNGMTPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKIKSGEAAEGEARSPSHKKRAAEERHPQGDRTFKKAAGASEEKKAEVPCKRREEEALVSGDAQPQDLGSRKLSPTKEAFGEQPLQLTTKPDLLAWDPARSSHPPAHHHHHHHHHHHHHTVGLNLSHARKRCLSETHGEREPCKKRLTARSISTPTCLGGSPVSEHPANVSPTAASLPQPEVILLDSDLDEPIDLRCVKMRSDAGEPPSTLQVKPEAPAVAAVVAPAPASEKPPAEAQEEPVEPLSEFKPFFGNIIITDVTANCLTVTFKEYVTV
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
function
FUNCTION: E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:29539416). Also acts as a histone reader, which specifically recognizes and binds histone H3 trimethylated at 'Lys-9' and 'Lys-27' (H3K9me3 and H3K27me3, respectively) via its chromo domain (PubMed:16537902, PubMed:29539416). Catalyzes sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression (By similarity). Acts as a regulator of brown adipocyte differentiation by mediating sumoylation of PRDM16, thereby preventing PRDM16 ubiquitination and degradation (PubMed:29539416). Monosumoylates ZBTB35 (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (By similarity). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (PubMed:22226355). {ECO:0000250|UniProtKB:O00257, ECO:0000269|PubMed:16537902, ECO:0000269|PubMed:22226355, ECO:0000269|PubMed:29539416}.
uniprot
proteins
mass_dalton
60523
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="F->A: Abolished binding to histone H3 trimethylated at 'Lys-9' (H3K9me3); when associated with L-35."; /evidence="ECO:0000269|PubMed:29539416"; MUTAGEN 35; /note="W->L: Abolished binding to histone H3 trimethylated at 'Lys-9' (H3K9me3); when associated with A-11."; /evidence="ECO:0000269|PubMed:29539416"; MUTAGEN 262..265; /note="Missing: Abolished ability to stabilize PRDM16."; /evidence="ECO:0000269|PubMed:29539416
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein sumoylation. {ECO:0000269|PubMed:29539416}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination regulates the function of the Polycomb group (PcG) multiprotein PRC1-like complex. Deubiquitinated by USP26. {ECO:0000250|UniProtKB:O00257}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16537902
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22226355
uniprot
proteins
pubmed
22872859
uniprot
proteins
pubmed
29539416
uniprot
proteins
pubmed
9367786
uniprot
proteins
sequence_length
551
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O00257}. Nucleus speckle {ECO:0000250|UniProtKB:O00257}.
uniprot
proteins