Acp3
entrez
56318
canonical
uniprot
Q8CE08
canonical
ensembl
ENSMUSG00000032561
resolver
ensp
ENSMUSP00000059889
resolver
ensp
ENSMUSP00000108209
resolver
genesymbol
Acp3
resolver
genesymbol_syn
Acpp
resolver
uniprot
A4QPG2
resolver
uniprot
B8JJZ5
resolver
uniprot
B8JJZ6
resolver
uniprot
Q8C682
resolver
uniprot
Q9QXH7
resolver
uniprot_entry
PPAP_MOUSE
resolver
uniprot_sec
A4QPG2
resolver
uniprot_sec
B8JJZ5
resolver
uniprot_sec
B8JJZ6
resolver
uniprot_sec
Q8C682
resolver
uniprot_sec
Q9QXH7
resolver
amino_acid_sequence
MRAVPLPLSRTASLSLGFLLLLSLCLDPGQAKELKFVTLVFRHGDRGPIETFPTDPITESSWPQGFGQLTQWGMEQHYELGSYIRKRYGRFLNDTYKHDQIYIRSTDVDRTLMSAMTNLAALFPPEGISIWNPRLLWQPIPVHTVSLSEDRLLYLPFRDCPRFEELKSETLESEEFLKRLHPYKSFLDTLSSLSGFDDQDLFGIWSKVYDPLFCESVHNFTLPSWATEDAMIKLKELSELSLLSLYGIHKQKEKSRLQGGVLVNEILKNMKLATQPQKYKKLVMYSAHDTTVSGLQMALDVYNGVLPPYASCHMMELYHDKGGHFVEMYYRNETQNEPYPLTLPGCTHSCPLEKFAELLDPVISQDWATECMATSSHQGRN
uniprot
proteins
ec_number
3.1.3.2
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
ec_number
3.1.3.5
uniprot
proteins
function
FUNCTION: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity). {ECO:0000250|UniProtKB:P15309}.; FUNCTION: [Isoform 2]: In addition to its tyrosine phosphatase activity, also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP. This extracellular adenosine leads to a decrease in chronic pain by activating A1R in nociceptive neurons. {ECO:0000269|PubMed:18940592}.
uniprot
proteins
mass_dalton
43717
uniprot
proteins
protein_family
Histidine acid phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17638863
uniprot
proteins
pubmed
18940592
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20084276
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000305|PubMed:17638863}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:17638863}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17638863}; Single-pass type I membrane protein {ECO:0000255}. Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles (PubMed:17638863). Colocalizes with LAMP2 on the lysosome membrane (By similarity). {ECO:0000250|UniProtKB:P15309, ECO:0000269|PubMed:17638863}.
uniprot
proteins
transmembrane_region
TRANSMEM Q8CE08-2:381..403; /note="Helical"; /evidence="ECO:0000303|PubMed:17638863
uniprot
proteins