CD3E
entrez
916
canonical
uniprot
P07766
canonical
ensembl
ENSG00000198851
resolver
ensp
ENSP00000354566
resolver
ensp
ENSP00000523997
resolver
enst
ENST00000361763
resolver
enst
ENST00000853938
resolver
genesymbol
CD3E
resolver
genesymbol_syn
T3E
resolver
hgnc
HGNC:1674
resolver
uniprot
A8K997
resolver
uniprot_entry
CD3E_HUMAN
resolver
uniprot_sec
A8K997
resolver
amino_acid_sequence
MQSGTHWRVLGLCLLSVGVWGQDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 18 (IMD18) [MIM:615615]: An autosomal recessive primary immunodeficiency characterized by onset in infancy or early childhood of recurrent infections. The severity is variable, encompassing both a mild immunodeficiency and severe combined immunodeficiency (SCID), resulting in early death without bone marrow transplantation in some patients. Immunologic work-up of the IMD18 SCID patients shows a T cell-negative, B cell-positive, natural killer (NK) cell-positive phenotype, whereas T-cell development is not impaired in the mild form of IMD18. {ECO:0000269|PubMed:15546002, ECO:0000269|PubMed:8490660}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response (PubMed:15294938, PubMed:15546002, PubMed:2470098, PubMed:40592325, PubMed:8490660). When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z (PubMed:2470098, PubMed:40592325). All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain (PubMed:2470098, PubMed:40592325). Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098, PubMed:40592325). CD3E ITAM phosphorylation creates docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (By similarity). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development (By similarity). Also participates in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128). In addition to its role as a TCR coreceptor, it serves as a receptor for ITPRIPL1 (PubMed:38614099). Ligand recognition inhibits T-cell activation by promoting interaction with NCK1, which prevents CD3E-ZAP70 interaction and blocks the ERK-NFkB signaling cascade and calcium influx (PubMed:12110186, PubMed:38614099). {ECO:0000250|UniProtKB:P22646, ECO:0000269|PubMed:10384095, ECO:0000269|PubMed:12110186, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:15546002, ECO:0000269|PubMed:2470098, ECO:0000269|PubMed:26507128, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:40592325, ECO:0000269|PubMed:8490660}.
uniprot
proteins
mass_dalton
23147
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. {ECO:0000269|PubMed:15534202, ECO:0000269|PubMed:2470098}.
uniprot
proteins
pubmed
10384095
uniprot
proteins
pubmed
12110186
uniprot
proteins
pubmed
12522270
uniprot
proteins
pubmed
1387664
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15136729
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15294938
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15534202
uniprot
proteins
pubmed
15546002
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15972658
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
2470098
uniprot
proteins
pubmed
26507128
uniprot
proteins
pubmed
3012357
uniprot
proteins
pubmed
3267235
uniprot
proteins
pubmed
38614099
uniprot
proteins
pubmed
40592325
uniprot
proteins
pubmed
8490660
uniprot
proteins
pubmed
9698567
uniprot
proteins
sequence_length
207
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10384095, ECO:0000269|PubMed:15294938}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 127..152; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins