Best1
entrez
24115
canonical
uniprot
O88870
canonical
ensembl
ENSMUSG00000037418
resolver
ensp
ENSMUSP00000113053
resolver
enst
ENSMUST00000117346
resolver
genesymbol
Best1
resolver
genesymbol_syn
Bmd1
resolver
genesymbol_syn
Vmd2
resolver
uniprot
B2RSY6
resolver
uniprot
Q6H1V0
resolver
uniprot_entry
BEST1_MOUSE
resolver
uniprot_sec
B2RSY6
resolver
uniprot_sec
Q6H1V0
resolver
activity_regulation
ACTIVITY REGULATION: Inactivated by sulfhydryl-reactive agents. {ECO:0000250|UniProtKB:O76090}.
uniprot
proteins
amino_acid_sequence
MTITYTNKVANARLGSFSSLLLCWRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVEGKDEEGRLLRRTLIRYAILGQVLILRSISTSVYKRFPTLHHLVLAGFMTHGEHKQLQKLGLPHNTFWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQFLNPNKDYPGHEMDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHQNLPPMERDMYWNEAAPQPPYTAASARSRRHSFMGSTFNISLKKEDLELWSKEEADTDKKESGYSSTIGCFLGLQPKNYHLPLKDLKTKLLCSKNPLLEGQCKDANQKNQKDVWKFKGLDFLKCVPRFKRRGSHCGPQAPSSHPTEQSAPSSSDTGDGPSTDYQEICHMKKKTVEFNLNIPESPTEHLQQRRLDQMSTNIQALMKEHAESYPYRDEAGTKPVLYE
uniprot
proteins
function
FUNCTION: Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+) (By similarity). Allows the movement of chloride and hydrogencarbonate (By similarity). Found in a partially open conformation leading to significantly smaller chloride movement (By similarity). Upon F2R/PAR-1 activation, the sequestered calcium is released into the cytosol of astrocytes, leading to the (Ca2+)-dependent release of L-glutamate into the synaptic cleft that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (PubMed:23021213, PubMed:25645137, PubMed:29121962). Upon activation of the norepinephrine-alpha-1 adrenergic receptor signaling pathway, transports as well D-serine than L-glutamate in a (Ca2+)-dependent manner, leading to activation of adjacent NMDAR receptors and therefore regulates the heterosynaptic long-term depression and metaplasticity during initial memory acquisition (PubMed:34952697). Releases the 4-aminobutanoate neurotransmitter in a (Ca2+)-dependent manner, and participates in its tonic release from cerebellar glial cells (PubMed:20929730). {ECO:0000250|UniProtKB:O76090, ECO:0000269|PubMed:20929730, ECO:0000269|PubMed:23021213, ECO:0000269|PubMed:25645137, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:34952697}.
uniprot
proteins
mass_dalton
63684
uniprot
proteins
mutagenesis
MUTAGEN 93; /note="W->C: Impairs calcium-dependent anion chanel activity."; /evidence="ECO:0000269|PubMed:20929730"; MUTAGEN 358; /note="S->A: Reduces interaction with YWHAG."; /evidence="ECO:0000269|PubMed:29121962
uniprot
proteins
protein_family
Anion channel-forming bestrophin (TC 1.A.46) family
uniprot
proteins
protein_family
Calcium-sensitive chloride channel subfamily
uniprot
proteins
pubmed
15218265
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20929730
uniprot
proteins
pubmed
23021213
uniprot
proteins
pubmed
25645137
uniprot
proteins
pubmed
29121962
uniprot
proteins
pubmed
34952697
uniprot
proteins
pubmed
9662395
uniprot
proteins
sequence_length
551
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23021213, ECO:0000269|PubMed:29121962}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O76090}. Basolateral cell membrane {ECO:0000250|UniProtKB:O76090}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O76090}. Note=Localized at the surface membrane of microdomains adjacent to glutamatergic synapses. {ECO:0000269|PubMed:23021213}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..51; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O76090"; TRANSMEM 61..82; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O76090"; TRANSMEM 238..255; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O76090"; TRANSMEM 275..288; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O76090
uniprot
proteins