TP63
entrez
8626
canonical
uniprot
Q9H3D4
canonical
ensembl
ENSG00000073282
resolver
ensp
ENSP00000264731
resolver
ensp
ENSP00000317510
resolver
ensp
ENSP00000346614
resolver
ensp
ENSP00000376253
resolver
ensp
ENSP00000376254
resolver
ensp
ENSP00000376256
resolver
ensp
ENSP00000387839
resolver
ensp
ENSP00000392488
resolver
ensp
ENSP00000394337
resolver
ensp
ENSP00000407144
resolver
genesymbol
TP63
resolver
genesymbol_syn
KET
resolver
genesymbol_syn
P63
resolver
genesymbol_syn
P73H
resolver
genesymbol_syn
P73L
resolver
genesymbol_syn
TP73L
resolver
hgnc
HGNC:15979
resolver
uniprot
A0A0S2Z4N5
resolver
uniprot
A0A0S2Z4N6
resolver
uniprot
A0A141PNN3
resolver
uniprot
A0A141PNN4
resolver
uniprot
B7Z8X6
resolver
uniprot
C9D7D0
resolver
uniprot
O75080
resolver
uniprot
O75195
resolver
uniprot
O75922
resolver
uniprot
O76078
resolver
uniprot
Q6VEG2
resolver
uniprot
Q6VEG3
resolver
uniprot
Q6VEG4
resolver
uniprot
Q6VFJ1
resolver
uniprot
Q6VFJ2
resolver
uniprot
Q6VFJ3
resolver
uniprot
Q6VH20
resolver
uniprot
Q7LDI3
resolver
uniprot
Q7LDI4
resolver
uniprot
Q7LDI5
resolver
uniprot
Q96KR0
resolver
uniprot
Q9H3D2
resolver
uniprot
Q9H3D3
resolver
uniprot
Q9H3P8
resolver
uniprot
Q9NPH7
resolver
uniprot
Q9P1B4
resolver
uniprot
Q9P1B5
resolver
uniprot
Q9P1B6
resolver
uniprot
Q9P1B7
resolver
uniprot
Q9UBV9
resolver
uniprot
Q9UE10
resolver
uniprot
Q9UP26
resolver
uniprot
Q9UP27
resolver
uniprot
Q9UP28
resolver
uniprot
Q9UP74
resolver
uniprot_entry
A0A0S2Z4N5_HUMAN
resolver
uniprot_entry
A0A0S2Z4N6_HUMAN
resolver
uniprot_entry
A0A141PNN3_HUMAN
resolver
uniprot_entry
A0A141PNN4_HUMAN
resolver
uniprot_entry
B7Z8X6_HUMAN
resolver
uniprot_entry
C9D7D0_HUMAN
resolver
uniprot_entry
P63_HUMAN
resolver
uniprot_sec
O75080
resolver
uniprot_sec
O75195
resolver
uniprot_sec
O75922
resolver
uniprot_sec
O76078
resolver
uniprot_sec
Q6VEG2
resolver
uniprot_sec
Q6VEG3
resolver
uniprot_sec
Q6VEG4
resolver
uniprot_sec
Q6VFJ1
resolver
uniprot_sec
Q6VFJ2
resolver
uniprot_sec
Q6VFJ3
resolver
uniprot_sec
Q6VH20
resolver
uniprot_sec
Q7LDI3
resolver
uniprot_sec
Q7LDI4
resolver
uniprot_sec
Q7LDI5
resolver
uniprot_sec
Q96KR0
resolver
uniprot_sec
Q9H3D2
resolver
uniprot_sec
Q9H3D3
resolver
uniprot_sec
Q9H3P8
resolver
uniprot_sec
Q9NPH7
resolver
uniprot_sec
Q9P1B4
resolver
uniprot_sec
Q9P1B5
resolver
uniprot_sec
Q9P1B6
resolver
uniprot_sec
Q9P1B7
resolver
uniprot_sec
Q9UBV9
resolver
uniprot_sec
Q9UE10
resolver
uniprot_sec
Q9UP26
resolver
uniprot_sec
Q9UP27
resolver
uniprot_sec
Q9UP28
resolver
uniprot_sec
Q9UP74
resolver
amino_acid_sequence
MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE
uniprot
proteins
disease_involvement
DISEASE: Acro-dermato-ungual-lacrimal-tooth syndrome (ADULT syndrome) [MIM:103285]: A form of ectodermal dysplasia. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ADULT syndrome involves ectrodactyly, syndactyly, finger- and toenail dysplasia, hypoplastic breasts and nipples, intensive freckling, lacrimal duct atresia, frontal alopecia, primary hypodontia and loss of permanent teeth. ADULT syndrome differs significantly from EEC3 syndrome by the absence of facial clefting. Inheritance is autosomal dominant. {ECO:0000269|PubMed:11929852}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) [MIM:106260]: An autosomal dominant condition characterized by congenital ectodermal dysplasia with coarse, wiry, sparse hair, dystrophic nails, slight hypohidrosis, scalp infections, ankyloblepharon filiform adnatum, maxillary hypoplasia, hypodontia and cleft lip/palate. {ECO:0000269|PubMed:11159940}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3) [MIM:604292]: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal dominant syndrome characterized by ectrodactyly of hands and feet, ectodermal dysplasia and facial clefting. {ECO:0000269|PubMed:10535733, ECO:0000269|PubMed:10839977, ECO:0000269|PubMed:11462173, ECO:0000269|PubMed:12838557}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Split-hand/foot malformation 4 (SHFM4) [MIM:605289]: A limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have intellectual disability, ectodermal and craniofacial findings, and orofacial clefting. {ECO:0000269|PubMed:10839977, ECO:0000269|PubMed:11462173}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Limb-mammary syndrome (LMS) [MIM:603543]: Characterized by ectrodactyly, cleft palate and mammary-gland abnormalities. {ECO:0000269|PubMed:11462173, ECO:0000269|PubMed:32067224}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Rapp-Hodgkin syndrome (RHS) [MIM:129400]: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Characterized by the combination of anhidrotic ectodermal dysplasia, cleft lip, and cleft palate. The clinical syndrome is comprised of a characteristic facies (narrow nose and small mouth), wiry, slow-growing, and uncombable hair, sparse eyelashes and eyebrows, obstructed lacrimal puncta/epiphora, bilateral stenosis of external auditory canals, microsomia, hypodontia, cone-shaped incisors, enamel hypoplasia, dystrophic nails, and cleft lip/cleft palate. RHS inheritance is autosomal dominant. {ECO:0000269|PubMed:12766194, ECO:0000269|PubMed:12939657, ECO:0000269|PubMed:15200513}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Orofacial cleft 8 (OFC8) [MIM:618149]: A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. {ECO:0000269|PubMed:16740912}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Premature ovarian failure 21 (POF21) [MIM:620311]: A form of premature ovarian failure, an ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. POF21 inheritance is autosomal dominant. {ECO:0000269|PubMed:30924587, ECO:0000269|PubMed:35801529, ECO:0000269|PubMed:36856110}. Note=The disease is caused by variants affecting the gene represented in this entry. Gain-of-function variants located in the transactivation inhibition domain are responsible for premature ovarian failure by inducing accelerated oocyte loss, as shown in mutant mice carrying the pathogenic variant p.Arg647Cys. {ECO:0000269|PubMed:36856110}.
uniprot
proteins
function
FUNCTION: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. Binds to an upstream regulatory region of the DSG1 gene and promotes transcription (PubMed:24594668). {ECO:0000269|PubMed:11641404, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12446779, ECO:0000269|PubMed:12446784, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:22197488, ECO:0000269|PubMed:24594668, ECO:0000269|PubMed:9774969}.
uniprot
proteins
mass_dalton
76785
uniprot
proteins
mutagenesis
MUTAGEN 18; /note="Y->A: No effect on transcriptional activation in a luciferase reporter assay."; /evidence="ECO:0000269|PubMed:35801529"; MUTAGEN 55; /note="F->A: Abrogates transcriptional activity and interaction with transactivation inhibition domain; when associated with A-59 and A-62."; /evidence="ECO:0000269|PubMed:12446779"; MUTAGEN 59; /note="W->A: Abrogates transcriptional activity and interaction with transactivation inhibition domain; when associated with A-55 and A-62."; /evidence="ECO:0000269|PubMed:12446779"; MUTAGEN 62; /note="L->A: Abrogates transcriptional activity and interaction with transactivation inhibition domain; when associated with A-55 and A-59."; /evidence="ECO:0000269|PubMed:12446779"; MUTAGEN 97; /note="R->C: No effect on transcriptional activation in a luciferase reporter assay."; /evidence="ECO:0000269|PubMed:35801529"; MUTAGEN 543; /note="Y->F: Abolishes ubiquitination."; /evidence="ECO:0000269|PubMed:18806757"; MUTAGEN 643; /note="R->A: Increased transcriptional activation in a luciferase reporter assay."; /evidence="ECO:0000269|PubMed:35801529"; MUTAGEN 647; /note="R->A: Increased transcriptional activation in a luciferase reporter assay."; /evidence="ECO:0000269|PubMed:35801529
uniprot
proteins
post_translational_modification
PTM: May be sumoylated. {ECO:0000250}.; PTM: Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. {ECO:0000269|PubMed:18806757}.
uniprot
proteins
protein_family
P53 family
uniprot
proteins
pubmed
10373484
uniprot
proteins
pubmed
10469295
uniprot
proteins
pubmed
10485447
uniprot
proteins
pubmed
10535733
uniprot
proteins
pubmed
10839977
uniprot
proteins
pubmed
10935472
uniprot
proteins
pubmed
11159940
uniprot
proteins
pubmed
11248048
uniprot
proteins
pubmed
11336476
uniprot
proteins
pubmed
11462173
uniprot
proteins
pubmed
11477076
uniprot
proteins
pubmed
11528512
uniprot
proteins
pubmed
11641404
uniprot
proteins
pubmed
11925430
uniprot
proteins
pubmed
11929852
uniprot
proteins
pubmed
12374749
uniprot
proteins
pubmed
12446779
uniprot
proteins
pubmed
12446784
uniprot
proteins
pubmed
12766194
uniprot
proteins
pubmed
12838557
uniprot
proteins
pubmed
12939657
uniprot
proteins
pubmed
15200513
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16740912
uniprot
proteins
pubmed
17846787
uniprot
proteins
pubmed
18806757
uniprot
proteins
pubmed
20123734
uniprot
proteins
pubmed
22197488
uniprot
proteins
pubmed
24594668
uniprot
proteins
pubmed
30924587
uniprot
proteins
pubmed
32067224
uniprot
proteins
pubmed
35801529
uniprot
proteins
pubmed
36856110
uniprot
proteins
pubmed
9662346
uniprot
proteins
pubmed
9662378
uniprot
proteins
pubmed
9703973
uniprot
proteins
pubmed
9774969
uniprot
proteins
pubmed
9799841
uniprot
proteins
sequence_length
680
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12446779, ECO:0000269|PubMed:20123734}.
uniprot
proteins