Cycs
entrez
13063
canonical
uniprot
P62897
canonical
ensembl
ENSMUSG00000058927
resolver
ensembl
ENSMUSG00000063694
resolver
ensp
ENSMUSP00000072829
resolver
ensp
ENSMUSP00000124523
resolver
enst
ENSMUST00000073080
resolver
enst
ENSMUST00000161401
resolver
genesymbol
Cycs
resolver
uniprot
P00009
resolver
uniprot
Q56A15
resolver
uniprot
Q8C2S2
resolver
uniprot_entry
CYC_MOUSE
resolver
uniprot_entry
Q56A15_MOUSE
resolver
uniprot_sec
P00009
resolver
uniprot_sec
Q8C2S2
resolver
amino_acid_sequence
MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAAGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKKATNE
uniprot
proteins
function
FUNCTION: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. {ECO:0000269|PubMed:12062423}.; FUNCTION: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. {ECO:0000269|PubMed:12062423}.
uniprot
proteins
mass_dalton
11605
uniprot
proteins
post_translational_modification
PTM: Binds 1 heme c group covalently per subunit.; PTM: Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration. {ECO:0000250}.
uniprot
proteins
protein_family
Cytochrome c family
uniprot
proteins
pubmed
12062423
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
191069
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
240690
uniprot
proteins
pubmed
2987801
uniprot
proteins
sequence_length
105
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
uniprot
proteins