CYP1A1
entrez
1543
canonical
uniprot
P04798
canonical
ensembl
ENSG00000140465
resolver
ensp
ENSP00000369050
resolver
ensp
ENSP00000378488
resolver
ensp
ENSP00000378489
resolver
ensp
ENSP00000482863
resolver
enst
ENST00000395049
resolver
enst
ENST00000617691
resolver
genesymbol
CYP1A1
resolver
hgnc
HGNC:2595
resolver
uniprot
A0N0X8
resolver
uniprot
A4F3V9
resolver
uniprot
A4F3W0
resolver
uniprot
E7EMT5
resolver
uniprot
Q53G18
resolver
uniprot_entry
A0N0X8_HUMAN
resolver
uniprot_entry
CP1A1_HUMAN
resolver
uniprot_entry
E7EMT5_HUMAN
resolver
uniprot_sec
A4F3V9
resolver
uniprot_sec
A4F3W0
resolver
uniprot_sec
Q53G18
resolver
amino_acid_sequence
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
ec_number
4.2.1.152
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15041462, PubMed:15805301, PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15041462, PubMed:15805301, PubMed:18577768, PubMed:19965576, PubMed:20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15805301). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed:15041462, PubMed:18577768). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:15041462, PubMed:19965576, PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed:20972997). Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed:15041462). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15041462, ECO:0000269|PubMed:15805301, ECO:0000269|PubMed:18577768, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20972997, ECO:0000269|PubMed:21068195}.
uniprot
proteins
mass_dalton
58165
uniprot
proteins
pathway_participation
PATHWAY: Steroid hormone biosynthesis. {ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15805301}.; PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000269|PubMed:15041462, ECO:0000269|PubMed:18577768, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20972997, ECO:0000269|PubMed:21068195}.; PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000269|PubMed:10681376}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10681376
uniprot
proteins
pubmed
10739168
uniprot
proteins
pubmed
11207026
uniprot
proteins
pubmed
11295847
uniprot
proteins
pubmed
11555828
uniprot
proteins
pubmed
12865317
uniprot
proteins
pubmed
14559847
uniprot
proteins
pubmed
15041462
uniprot
proteins
pubmed
15469410
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15618738
uniprot
proteins
pubmed
15643613
uniprot
proteins
pubmed
15805301
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
1722803
uniprot
proteins
pubmed
18577768
uniprot
proteins
pubmed
19965576
uniprot
proteins
pubmed
20972997
uniprot
proteins
pubmed
21068195
uniprot
proteins
pubmed
23508959
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2989797
uniprot
proteins
pubmed
3000715
uniprot
proteins
pubmed
3019683
uniprot
proteins
pubmed
3838385
uniprot
proteins
pubmed
8895751
uniprot
proteins
pubmed
9500998
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P00185}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00185}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00185}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00185}. Microsome membrane {ECO:0000250|UniProtKB:P00185}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00185}. Cytoplasm {ECO:0000250|UniProtKB:P00185}.
uniprot
proteins