KCNMB4
entrez
27345
canonical
uniprot
Q86W47
canonical
ensembl
ENSG00000135643
resolver
ensp
ENSP00000258111
resolver
enst
ENST00000258111
resolver
genesymbol
KCNMB4
resolver
hgnc
HGNC:6289
resolver
uniprot
Q8IVR3
resolver
uniprot
Q9NPA4
resolver
uniprot
Q9P0G5
resolver
uniprot_entry
KCMB4_HUMAN
resolver
uniprot_sec
Q8IVR3
resolver
uniprot_sec
Q9NPA4
resolver
uniprot_sec
Q9P0G5
resolver
amino_acid_sequence
MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS
uniprot
proteins
function
FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations. {ECO:0000269|PubMed:10692449, ECO:0000269|PubMed:10792058, ECO:0000269|PubMed:10828459}.
uniprot
proteins
mass_dalton
23949
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="T->A: Suppresses the effect of okadaic acid and increases activation time constant; when associated with A-17 and A-210."; /evidence="ECO:0000269|PubMed:11790768"; MUTAGEN 11; /note="T->D: Suppresses its effect on KCNMA1 channel activation and on deactivation kinetics; when associated with E-17 and E-210."; /evidence="ECO:0000269|PubMed:11790768"; MUTAGEN 17; /note="S->A: Suppresses the effect of okadaic acid and increases activation time constant; when associated with A-11 and A-210."; /evidence="ECO:0000269|PubMed:11790768"; MUTAGEN 17; /note="S->E: Suppresses its effect on KCNMA1 channel activation and on deactivation kinetics; when associated with D-11 and E-210."; /evidence="ECO:0000269|PubMed:11790768"; MUTAGEN 53; /note="N->A: Loss of N-glycosylation and reduced protection against charybdotoxin; when associated with A-90."; /evidence="ECO:0000269|PubMed:12223479"; MUTAGEN 90; /note="N->A: Loss of N-glycosylation and reduced protection against charybdotoxin; when associated with A-53."; /evidence="ECO:0000269|PubMed:12223479"; MUTAGEN 210; /note="S->A: Suppresses the effect of okadaic acid and increases activation time constant; when associated with A-11 and A-17."; /evidence="ECO:0000269|PubMed:11790768"; MUTAGEN 210; /note="S->E: Suppresses its effect on KCNMA1 channel activation and on deactivation kinetics; when associated with D-11 and E-17."; /evidence="ECO:0000269|PubMed:11790768
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics. {ECO:0000269|PubMed:11790768}.; PTM: N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin. {ECO:0000269|PubMed:10792058, ECO:0000269|PubMed:12223479}.
uniprot
proteins
protein_family
KCNMB (TC 8.A.14.1) family
uniprot
proteins
protein_family
KCNMB4 subfamily
uniprot
proteins
pubmed
10692449
uniprot
proteins
pubmed
10792058
uniprot
proteins
pubmed
10804197
uniprot
proteins
pubmed
10828459
uniprot
proteins
pubmed
11790768
uniprot
proteins
pubmed
12136044
uniprot
proteins
pubmed
12223479
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25561520
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins