Elk1
entrez
13712
canonical
uniprot
P41969
canonical
ensembl
ENSMUSG00000009406
resolver
ensp
ENSMUSP00000009550
resolver
enst
ENSMUST00000009550
resolver
genesymbol
Elk1
resolver
uniprot
Q3V1M9
resolver
uniprot_entry
ELK1_MOUSE
resolver
uniprot_sec
Q3V1M9
resolver
amino_acid_sequence
MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSAIAMAPATVHAGPGDTATGKPGTPKGAGMTGQGGLARSSRNEYMRSGLYSTFTIQSLQPQPQPPIPPRPASVLPNTTPAGVPAPASGSRSTSPNPLEACLEAEEAGLPLQVILTPPEAPNQKSEELSLDPSFGHPQPPEVKVEGPKEELEAARAGGFSSEAVKAEPEVSASEGLLARLPAILTENTAQVCGLSTSTTEITQPQKGRKPRDLELPLSPSLLGGQGPERTPGSGTSSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP
uniprot
proteins
function
FUNCTION: Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (By similarity). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (By similarity). {ECO:0000250|UniProtKB:A4GTP4, ECO:0000250|UniProtKB:P19419}.
uniprot
proteins
mass_dalton
45271
uniprot
proteins
post_translational_modification
PTM: Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention (By similarity). {ECO:0000250|UniProtKB:P19419}.; PTM: On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1 but also MAPK8 and/or MAPK9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CaMK4, MAPK11, MAPK12 and MAPK14 (By similarity). Upon bFGF stimulus, phosphorylated by PAK1 (By similarity). Phosphorylated by PRP4K at Thr-418; phosphorylation activation ELK1 transcriptional activity (By similarity). {ECO:0000250|UniProtKB:A4GTP4, ECO:0000250|UniProtKB:P19419}.
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7958835
uniprot
proteins
pubmed
8863747
uniprot
proteins
sequence_length
429
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins