Slc1a2
entrez
20511
canonical
uniprot
P43006
canonical
ensembl
ENSMUSG00000005089
resolver
ensp
ENSMUSP00000005220
resolver
ensp
ENSMUSP00000079100
resolver
ensp
ENSMUSP00000106843
resolver
ensp
ENSMUSP00000106844
resolver
enst
ENSMUST00000111213
resolver
genesymbol
Slc1a2
resolver
genesymbol_syn
Eaat2
resolver
genesymbol_syn
Glt1
resolver
uniprot
A2APL5
resolver
uniprot
A2APL7
resolver
uniprot
O35877
resolver
uniprot
O54686
resolver
uniprot
O54687
resolver
uniprot
Q3UYK6
resolver
uniprot_entry
A2APL5_MOUSE
resolver
uniprot_entry
A2APL7_MOUSE
resolver
uniprot_entry
EAA2_MOUSE
resolver
uniprot_entry
Q3UYK6_MOUSE
resolver
uniprot_sec
O35877
resolver
uniprot_sec
O54686
resolver
uniprot_sec
O54687
resolver
amino_acid_sequence
MASTEGANNMPKQVEVRMHDSHLSSDEPKHRNLGMRMCDKLGKNLLLSLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISMLNETMNEAPEETKIVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGEQAKLMVEFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHRMQEDIEMTKTQSIYDDKNHRESNSNQCVYAAHNSVVIDECKVTLAANGKSADCSVEEEPWKREK
uniprot
proteins
function
FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7557442, PubMed:7698742, PubMed:9373176). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (PubMed:9180080). {ECO:0000250|UniProtKB:P43004, ECO:0000269|PubMed:7557442, ECO:0000269|PubMed:7698742, ECO:0000269|PubMed:9180080, ECO:0000269|PubMed:9373176}.
uniprot
proteins
mass_dalton
62030
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="C->S: Severely impairs glutamate uptake activity."; /evidence="ECO:0000269|PubMed:20685337
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:P43004}.; PTM: Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity. {ECO:0000269|PubMed:20685337}.
uniprot
proteins
protein_family
Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family
uniprot
proteins
protein_family
SLC1A2 subfamily
uniprot
proteins
pubmed
16880397
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
20685337
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7557442
uniprot
proteins
pubmed
7698742
uniprot
proteins
pubmed
7766664
uniprot
proteins
pubmed
9180080
uniprot
proteins
pubmed
9373176
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7557442, ECO:0000269|PubMed:7698742, ECO:0000269|PubMed:9373176}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43004}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..64; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 121..142; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 235..258; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 268..295; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 317..338; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 384..410; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 471..492; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P43003
uniprot
proteins