CTU1
entrez
90353
canonical
uniprot
Q7Z7A3
canonical
ensembl
ENSG00000142544
resolver
ensp
ENSP00000390011
resolver
ensp
ENSP00000606137
resolver
ensp
ENSP00000621838
resolver
ensp
ENSP00000621839
resolver
enst
ENST00000421832
resolver
enst
ENST00000936078
resolver
enst
ENST00000951779
resolver
enst
ENST00000951780
resolver
genesymbol
CTU1
resolver
genesymbol_syn
ATPBD3
resolver
genesymbol_syn
NCS6
resolver
hgnc
HGNC:29590
resolver
uniprot
A8K558
resolver
uniprot
Q96GZ7
resolver
uniprot_entry
CTU1_HUMAN
resolver
uniprot_sec
A8K558
resolver
uniprot_sec
Q96GZ7
resolver
amino_acid_sequence
MPAPPCASCHAARAALRRPLSGQALCGACFCAAFEAEVLHTVLAGRLLPPGAVVAVGASGGKDSTVLAHVLRALAPRLGISLQLVAVDEGIGGYRDAALAAVRRQAARWELPLTVVAYEDLFGGWTMDAVARSTAGSGRSRSCCTFCGVLRRRALEEGARRVGATHIVTGHNADDMAETVLMNFLRGDAGRLARGGGLGSPGEGGALPRCRPLQFASQKEVVLYAHFRRLDYFSEECVYAPEAFRGHARDLLKRLEAARPSAVLDLVHSAERLALAPAARPPRPGACSRCGALASRALCQACALLDGLNRGRPRLAIGKGRRGLDEEATPGTPGDPARPPASKAVPTF
uniprot
proteins
ec_number
2.7.7.-
uniprot
proteins
function
FUNCTION: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255|HAMAP-Rule:MF_03053, ECO:0000269|PubMed:19017811}.
uniprot
proteins
mass_dalton
36450
uniprot
proteins
pathway_participation
PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03053}.
uniprot
proteins
protein_family
CTU1/NCS6/ATPBD3 subfamily
uniprot
proteins
protein_family
TtcA family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19017811
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
348
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins