Txnip
entrez
117514
canonical
uniprot
Q5M7W1
canonical
ensembl
ENSRNOG00000021201
resolver
ensembl
ENSRNOG00055032474
resolver
ensembl
ENSRNOG00060012506
resolver
ensembl
ENSRNOG00065032017
resolver
ensp
ENSRNOP00000028793
resolver
ensp
ENSRNOP00055046247
resolver
ensp
ENSRNOP00060016720
resolver
ensp
ENSRNOP00065045322
resolver
enst
ENSRNOT00000028793
resolver
enst
ENSRNOT00055056093
resolver
enst
ENSRNOT00060021196
resolver
enst
ENSRNOT00065055127
resolver
genesymbol
Txnip
resolver
genesymbol_syn
Vdup1
resolver
uniprot_entry
TXNIP_RAT
resolver
amino_acid_sequence
MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVTVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTLDYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQEAKKNFEVMDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDDISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWIDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDVDDSQDSPIFMYAPEFQFMPPPTYTEVDPCVLNNNNNNVQ
uniprot
proteins
function
FUNCTION: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (By similarity). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (By similarity). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). {ECO:0000250|UniProtKB:Q8BG60, ECO:0000250|UniProtKB:Q9H3M7}.
uniprot
proteins
mass_dalton
44018
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; undergoes heterotypic 'Lys-48'-/'Lys-63'-branched polyubiquitination catalyzed by ITCH and UBR5 resulting in proteasomal degradation. Deubiquitinated by USP5, leading to TXNIP stabilization. {ECO:0000250|UniProtKB:Q9H3M7}.
uniprot
proteins
protein_family
Arrestin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
394
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BG60}.
uniprot
proteins