Gpx1
entrez
24404
canonical
uniprot
P04041
canonical
ensembl
ENSRNOG00000048812
resolver
ensembl
ENSRNOG00055013502
resolver
ensembl
ENSRNOG00060022938
resolver
ensembl
ENSRNOG00065006611
resolver
ensp
ENSRNOP00000066577
resolver
ensp
ENSRNOP00055018786
resolver
ensp
ENSRNOP00060032843
resolver
ensp
ENSRNOP00065007453
resolver
enst
ENSRNOT00055023147
resolver
enst
ENSRNOT00060039711
resolver
enst
ENSRNOT00065010211
resolver
genesymbol
Gpx1
resolver
uniprot
O08946
resolver
uniprot
Q4PIY2
resolver
uniprot
Q91WZ5
resolver
uniprot_entry
GPX1_RAT
resolver
uniprot_sec
O08946
resolver
uniprot_sec
Q4PIY2
resolver
uniprot_sec
Q91WZ5
resolver
amino_acid_sequence
MSAARLSAVAQSTVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTTRDYTEMNDLQKRLGPRGLVVLGFPCNQFGHQENGKNEEILNSLKYVRPGGGFEPNFTLFEKCEVNGEKAHPLFTFLRNALPAPSDDPTALMTDPKYIIWSPVCRNDISWNFEKFLVGPDGVPVRRYSRRFRTIDIEPDIEALLSKQPSNP
uniprot
proteins
ec_number
1.11.1.12
uniprot
proteins
ec_number
1.11.1.9
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis. Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway. {ECO:0000250|UniProtKB:P11352}.
uniprot
proteins
mass_dalton
22305
uniprot
proteins
post_translational_modification
PTM: During periods of oxidative stress, Sec-47 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine. {ECO:0000250|UniProtKB:P11352}.
uniprot
proteins
protein_family
Glutathione peroxidase family
uniprot
proteins
pubmed
1451786
uniprot
proteins
pubmed
1640255
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2838821
uniprot
proteins
pubmed
3387231
uniprot
proteins
pubmed
3408482
uniprot
proteins
pubmed
6217842
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P11352}. Mitochondrion {ECO:0000250|UniProtKB:P11352}.
uniprot
proteins