PSMB2
entrez
5690
canonical
uniprot
P49721
canonical
ensembl
ENSG00000126067
resolver
ensp
ENSP00000362334
resolver
ensp
ENSP00000479706
resolver
ensp
ENSP00000768985
resolver
enst
ENST00000373237
resolver
enst
ENST00000621781
resolver
genesymbol
PSMB2
resolver
hgnc
HGNC:9539
resolver
uniprot
A0A087WVV1
resolver
uniprot
A0A140VJS6
resolver
uniprot
B7Z478
resolver
uniprot
D3DPS0
resolver
uniprot
P31145
resolver
uniprot
Q9BWZ9
resolver
uniprot_entry
A0A087WVV1_HUMAN
resolver
uniprot_entry
A0A140VJS6_HUMAN
resolver
uniprot_entry
B7Z478_HUMAN
resolver
uniprot_entry
PSB2_HUMAN
resolver
uniprot_sec
D3DPS0
resolver
uniprot_sec
P31145
resolver
uniprot_sec
Q9BWZ9
resolver
amino_acid_sequence
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
uniprot
proteins
function
FUNCTION: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
uniprot
proteins
mass_dalton
22836
uniprot
proteins
protein_family
Peptidase T1B family
uniprot
proteins
pubmed
12181345
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
14550573
uniprot
proteins
pubmed
15244466
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19787249
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23495936
uniprot
proteins
pubmed
25599644
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26133119
uniprot
proteins
pubmed
26657688
uniprot
proteins
pubmed
27176742
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
27493187
uniprot
proteins
pubmed
34711951
uniprot
proteins
pubmed
7811265
uniprot
proteins
pubmed
7918633
uniprot
proteins
pubmed
8610016
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
uniprot
proteins