Tomt
entrez
308868
canonical
uniprot
B6CZ62
canonical
ensembl
ENSRNOG00000023434
resolver
ensembl
ENSRNOG00055028791
resolver
ensembl
ENSRNOG00060003176
resolver
ensembl
ENSRNOG00065022810
resolver
ensp
ENSRNOP00000036144
resolver
ensp
ENSRNOP00055041054
resolver
ensp
ENSRNOP00060003847
resolver
ensp
ENSRNOP00065031598
resolver
enst
ENSRNOT00000039564
resolver
enst
ENSRNOT00055049856
resolver
enst
ENSRNOT00060005211
resolver
enst
ENSRNOT00065038941
resolver
genesymbol
Tomt
resolver
genesymbol_syn
Comt2
resolver
uniprot_entry
TOMT_RAT
resolver
amino_acid_sequence
MSPAIALAFLPLVVTLLVRYRHHFRLLVRTVLLRSFRDCLSGLRIEERAFSYVITHALPGDPGHILTTLDHWSSCCEYLSHMGPIKGQILMRLVEEKAPACVLELGTHCGYSTLLIARALPPGSRLLTVERDSRTAAVAEKVIRLAGFDEQMVELIAGSSEEVIPRLRAQHQLNRADLVLLAHRPRYYLRDLQLLEAHALLPHGATVLADHVLFPGAPRFLQYTKSCGRYRCRLHHTSLPDFPAIKDGIAQLTYTGPG
uniprot
proteins
ec_number
2.1.1.6
uniprot
proteins
function
FUNCTION: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (By similarity). Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (By similarity). {ECO:0000250|UniProtKB:A1Y9I9, ECO:0000250|UniProtKB:Q8WZ04}.
uniprot
proteins
mass_dalton
28864
uniprot
proteins
protein_family
Cation-dependent O-methyltransferase family
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
18953341
uniprot
proteins
sequence_length
258
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A1Y9I9}. Endoplasmic reticulum {ECO:0000250|UniProtKB:A1Y9I9}. Note=Localized to the cell body of the cochlear hair cells, but is not present in the stereocilia. Present but not restricted to the apical cistern, Hensen's body and the subsurface cistern. {ECO:0000250|UniProtKB:A1Y9I9}.
uniprot
proteins