GFM1
entrez
85476
canonical
uniprot
Q96RP9
canonical
ensembl
ENSG00000168827
resolver
ensp
ENSP00000264263
resolver
ensp
ENSP00000418755
resolver
ensp
ENSP00000419038
resolver
ensp
ENSP00000537744
resolver
ensp
ENSP00000630434
resolver
enst
ENST00000478576
resolver
genesymbol
GFM1
resolver
genesymbol_syn
EFG
resolver
genesymbol_syn
EFG1
resolver
genesymbol_syn
GFM
resolver
hgnc
HGNC:13780
resolver
uniprot
A6NCI9
resolver
uniprot
B2RCB9
resolver
uniprot
B3KRW1
resolver
uniprot
C9IZ01
resolver
uniprot
E5KND5
resolver
uniprot
Q6GTN2
resolver
uniprot
Q96T39
resolver
uniprot_entry
C9IZ01_HUMAN
resolver
uniprot_entry
E5KND5_HUMAN
resolver
uniprot_entry
EFGM_HUMAN
resolver
uniprot_sec
A6NCI9
resolver
uniprot_sec
B2RCB9
resolver
uniprot_sec
B3KRW1
resolver
uniprot_sec
Q6GTN2
resolver
uniprot_sec
Q96T39
resolver
amino_acid_sequence
MRLLGAAAVAALGRGRAPASLGWQRKQVNWKACRWSSSGVIPNEKIRNIGISAHIDSGKTTLTERVLYYTGRIAKMHEVKGKDGVGAVMDSMELERQRGITIQSAATYTMWKDVNINIIDTPGHVDFTIEVERALRVLDGAVLVLCAVGGVQCQTMTVNRQMKRYNVPFLTFINKLDRMGSNPARALQQMRSKLNHNAAFMQIPMGLEGNFKGIVDLIEERAIYFDGDFGQIVRYGEIPAELRAAATDHRQELIECVANSDEQLGEMFLEEKIPSISDLKLAIRRATLKRSFTPVFLGSALKNKGVQPLLDAVLEYLPNPSEVQNYAILNKEDDSKEKTKILMNSSRDNSHPFVGLAFKLEVGRFGQLTYVRSYQGELKKGDTIYNTRTRKKVRLQRLARMHADMMEDVEEVYAGDICALFGIDCASGDTFTDKANSGLSMESIHVPDPVISIAMKPSNKNDLEKFSKGIGRFTREDPTFKVYFDTENKETVISGMGELHLEIYAQRLEREYGCPCITGKPKVAFRETITAPVPFDFTHKKQSGGAGQYGKVIGVLEPLDPEDYTKLEFSDETFGSNIPKQFVPAVEKGFLDACEKGPLSGHKLSGLRFVLQDGAHHMVDSNEISFIRAGEGALKQALANATLCILEPIMAVEVVAPNEFQGQVIAGINRRHGVITGQDGVEDYFTLYADVPLNDMFGYSTELRSCTEGKGEYTMEYSRYQPCLPSTQEDVINKYLEATGQLPVKKGKAKN
uniprot
proteins
disease_involvement
DISEASE: Combined oxidative phosphorylation deficiency 1 (COXPD1) [MIM:609060]: A mitochondrial disease resulting in early rapidly progressive hepatoencephalopathy. {ECO:0000269|PubMed:15537906, ECO:0000269|PubMed:17160893, ECO:0000269|PubMed:21119709, ECO:0000269|PubMed:26741492}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03061, ECO:0000269|PubMed:19716793}.
uniprot
proteins
mass_dalton
83471
uniprot
proteins
pathway_participation
PATHWAY: Protein biosynthesis; polypeptide chain elongation. {ECO:0000255|HAMAP-Rule:MF_03061, ECO:0000269|PubMed:19716793}.
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
EF-G/EF-2 subfamily
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
11374907
uniprot
proteins
pubmed
11735030
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15358359
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15537906
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17160893
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19716793
uniprot
proteins
pubmed
21119709
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26741492
uniprot
proteins
sequence_length
751
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03061}.
uniprot
proteins