P4htm
entrez
74443
canonical
uniprot
Q8BG58
canonical
ensembl
ENSMUSG00000006675
resolver
ensp
ENSMUSP00000006853
resolver
ensp
ENSMUSP00000229725
resolver
genesymbol
P4htm
resolver
genesymbol_syn
Ph4
resolver
uniprot
Q2M2M8
resolver
uniprot
Q8CAF1
resolver
uniprot
Q9D499
resolver
uniprot_entry
P4HTM_MOUSE
resolver
uniprot_entry
Q2M2M8_MOUSE
resolver
uniprot_sec
Q8CAF1
resolver
uniprot_sec
Q9D499
resolver
amino_acid_sequence
MAAAVATVQRPEAETVEEASNLQWPLPPEHRPSGAATRPGDSEDAPVRPLCKPRGICSRAYFLVLMVFVHLYLGNVLALLLFVHYSNGDESTDPGPQRREQSPQPVPTLGPLTRLEGIKVGYERKVQVVAGRDHFIRTLSLKPLLFEIPGFLSDEECRLIIHLAQMKGLQRSQILPTEEYEEAMSAMQVSQLDLFQLLDQNHDGRLQLREVLAQTRLGNGRWMTPENIQEMYSAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESNELVRNSHHTWLHQGEGAHHVMRAIRQRVLRLTRLSPEIVEFSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGEVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGMDSQPEWALDRAYSDARVEL
uniprot
proteins
ec_number
1.14.11.29
uniprot
proteins
function
FUNCTION: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. {ECO:0000250|UniProtKB:Q9NXG6}.
uniprot
proteins
mass_dalton
57049
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27466183
uniprot
proteins
sequence_length
503
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 62..82; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins