DENND10
entrez
404636
canonical
uniprot
Q8TCE6
canonical
ensembl
ENSG00000119979
resolver
ensp
ENSP00000354688
resolver
ensp
ENSP00000496780
resolver
ensp
ENSP00000798270
resolver
enst
ENST00000648560
resolver
genesymbol
DENND10
resolver
genesymbol_syn
FAM45A
resolver
hgnc
HGNC:31793
resolver
uniprot
A0A3B3IRE4
resolver
uniprot
B1AMV6
resolver
uniprot
B4DDC3
resolver
uniprot
B4DMU4
resolver
uniprot
B4DNL9
resolver
uniprot
D3DRC8
resolver
uniprot
Q9NXW4
resolver
uniprot_entry
A0A3B3IRE4_HUMAN
resolver
uniprot_entry
B4DMU4_HUMAN
resolver
uniprot_entry
B4DNL9_HUMAN
resolver
uniprot_entry
DEN10_HUMAN
resolver
uniprot_sec
B1AMV6
resolver
uniprot_sec
B4DDC3
resolver
uniprot_sec
D3DRC8
resolver
uniprot_sec
Q9NXW4
resolver
amino_acid_sequence
MAAAEVADTQLMLGVGLIEKDTNGEVLWVWCYPSTTATLRNLLLRKCCLTDENKLLHPFVFGQYRRTWFYITTIEVPDSSILKKVTHFSIVLTAKDFNPEKYAAFTRILCRMYLKHGSPVKMMESYIAVLTKGICQSEENGSFLSKDFDARKAYLAGSIKDIVSQFGMETVILHTALMLKKRIVVYHPKIEAVQEFTRTLPALVWHRQDWTILHSYVHLNADELEALQMCTGYVAGFVDLEVSNRPDLYDVFVNLAESEITIAPLAKEAMAMGKLHKEMGQLIVQSAEDPEKSESHVIQDIALKTREIFTNLAPFSEVSADGEKRVLNLEALKQKRFPPATENFLYHLAAAEQMLKI
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B (PubMed:38459129). Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP-bound form (PubMed:30771381, PubMed:38459129). {ECO:0000269|PubMed:30771381, ECO:0000269|PubMed:38459129}.
uniprot
proteins
mass_dalton
40513
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="L->E: Impairs interaction with CCDC93."; /evidence="ECO:0000269|PubMed:37172566"; MUTAGEN 123; /note="M->E: Impairs interaction with CCDC93."; /evidence="ECO:0000269|PubMed:37172566"; MUTAGEN 127; /note="I->E: Impairs interaction with CCDC93."; /evidence="ECO:0000269|PubMed:37172566
uniprot
proteins
protein_family
DENND10 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
30771381
uniprot
proteins
pubmed
37172566
uniprot
proteins
pubmed
38459129
uniprot
proteins
pubmed
38504028
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome {ECO:0000269|PubMed:30771381}.
uniprot
proteins