Tktl1
entrez
83553
canonical
uniprot
Q99MX0
canonical
ensembl
ENSMUSG00000031397
resolver
ensp
ENSMUSP00000010127
resolver
enst
ENSMUST00000010127
resolver
genesymbol
Tktl1
resolver
uniprot
B1AYP0
resolver
uniprot
Q684Q5
resolver
uniprot
Q8CDU7
resolver
uniprot_entry
TKTL1_MOUSE
resolver
uniprot_sec
B1AYP0
resolver
uniprot_sec
Q684Q5
resolver
uniprot_sec
Q8CDU7
resolver
amino_acid_sequence
MSEAEASSGMAHNAGPDEKTLQVLRDMANRLRIRSIKATNSSTTSYLIPCSNAEIMSVLFFYTMRYKQEDPENPDNDRCILSKGLPFVNVATGWPGQGLGAACGMAYTGKYFDQASYRVFCLLGDEESTEGSVWEAFAFASYYNLDNLMAIFDVNRIGHSSSMSVEHCIAIYQKRCEAFGWNTYVVDGRDVKTLCHVFSQAAQVRGKPTAVVAKTFKARGMPNVEDAESWYGRPMPKERADAIVKLIESQIQTNKILVPSPPIEDSPQINIMNICMTSPPVYVADDKVSTQRACGLALAKLGHENDRVIVLGSDTKNCNFSDIFKKEHPERFIQCCIAEQNMVNVALGCSTRDRTIVFAYSFAAFFTRAFDQIRLGAISQININLIGCHCGVSTGDDNPYHMALEDLAMFRAIPNCVVFYPSDAVSTEHAVYLAANTKEMCFIRTSQAETAIIYTTQETFQIGQAKVVRHSDNDKVIVIGAGVTLHEALVAAAELSKEDISIRVIDLFTIKPLDIATIISNAKATGGRIITVEDHYPEGGIGGAVCAAVSMEPNIVVHNLAVMDVPRSGRCNEALDFSGISSRHIIVAVKCILMT
uniprot
proteins
ec_number
2.2.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity). Thus, catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate (By similarity). The phosphate group of the substrate plays a role in stabilizing the substrate-thiamine intermediate while preventing the formation of the reactive enamine intermediate (By similarity). Can also use fructose-6-phosphate as a ketose donor (By similarity). {ECO:0000250|UniProtKB:P29401}.
uniprot
proteins
mass_dalton
65245
uniprot
proteins
protein_family
Transketolase family
uniprot
proteins
pubmed
11279525
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36074851
uniprot
proteins
sequence_length
595
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P51854}.
uniprot
proteins