Tbcb
entrez
66411
canonical
uniprot
Q9D1E6
canonical
ensembl
ENSMUSG00000006095
resolver
ensp
ENSMUSP00000006254
resolver
ensp
ENSMUSP00000308876
resolver
enst
ENSMUST00000006254
resolver
genesymbol
Tbcb
resolver
genesymbol_syn
Ckap1
resolver
uniprot
Q9CWR6
resolver
uniprot
Q9DCZ6
resolver
uniprot_entry
TBCB_MOUSE
resolver
uniprot_sec
Q9CWR6
resolver
uniprot_sec
Q9DCZ6
resolver
amino_acid_sequence
MEVTGISAPTVMVFISSSLNSFRSEKRYSRSLTIAEFKCKLELVVGSPASCMELELYGADDKFYSKLDQEDALLGSYPVDDGCRIHVIDHSGVRLGEYEDVSKVEKYEISPEAYERRQNTVRSFMKRSKLGPYNEELRAQQEAEAAQRLSEEKAQASAISVGSRCEVRAPDHSLRRGTVMYVGLTDFKPGYWVGVRYDEPLGKNDGSVNGKRYFECQAKYGAFVKPSAVTVGDFPEEDYGLDEM
uniprot
proteins
function
FUNCTION: Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (By similarity). Involved in regulation of tubulin heterodimer dissociation (PubMed:17184771). May function as a negative regulator of axonal growth (PubMed:17217416). {ECO:0000250|UniProtKB:Q99426, ECO:0000269|PubMed:17184771, ECO:0000269|PubMed:17217416}.
uniprot
proteins
mass_dalton
27386
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PAK1 is required for normal function. {ECO:0000250|UniProtKB:Q99426}.; PTM: Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome. {ECO:0000250|UniProtKB:Q99426}.
uniprot
proteins
protein_family
TBCB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17184771
uniprot
proteins
pubmed
17217416
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17217416}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17217416}. Note=Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone. {ECO:0000269|PubMed:17217416}.
uniprot
proteins