Q99PS8
uniprot
Q99PS8
canonical
amino_acid_sequence
MKVLTTALLLVTLQCSHALSPTNCDASKPLAEKVLDLINKGRRSGYTFQLLRVSDAHLDRVETATIYYLVLDVVESDCWVLSTKAQDECLPAMRTSEVVIGQCKVIATRYSNESQDLSVNGYNCTMRSVSSAYINTKDSPVLVDSFEDSEPYRKLARKALDKYKAENGDFASFRVERAERVIRMRGGERTSYFIEFSVRNCSTQHFPRHPPVFGLCRVVLTYSTEASDLETPEYTDLICEVFNTEDLKNRSDMKPHRGHEHPHCDKHLCKLSGPRDHHHTHKTHEIGCPPPPEGKDNSDRPPLQEGALPQMLPGHSGPSGTNRSHRPPHNHSCNEHPCHGQHPHGHHPHGQHPHGHHPHGQHPHGHHPHGQHPHGHHPHGQHPHGHHPHGHHPHGDHPHGHHPHGHDFLDYGPCDPPSNSQELKGQYHRGHGPPHGHSRKRGPGKGLFPFHQRQIGYVYRLPPLNVGEVLTPPEANFPIFSLPNCNRPPQPEIRPFPQTASKSCPGKFEGKFPQVSNFFEHTPPK
uniprot
proteins
function
FUNCTION: Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
59049
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250}.; PTM: Proteolytic cleavage produces several HRG fragments which are mostly disulfide-linked and, therefore, not released. Cleavage by plasmin is inhibited in the presence of heparin, zinc ions or in an acidic environment. Cleavage reduces binding of HRG to heparan sulfate, but enhances the ability of HRG to bind and tether plasminogen to the cell surface. On platelet activation, releases a 33 kDa antiangiogenic peptide which encompasses the HRR. Also cleaved in the C-terminal by plasmin (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
10849117
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10849117}.
uniprot
proteins