Cybrd1
entrez
295669
canonical
uniprot
Q5RKJ2
canonical
ensembl
ENSRNOG00000009620
resolver
ensembl
ENSRNOG00055024392
resolver
ensembl
ENSRNOG00060002600
resolver
ensembl
ENSRNOG00065016809
resolver
ensp
ENSRNOP00000012942
resolver
ensp
ENSRNOP00055034154
resolver
ensp
ENSRNOP00060002940
resolver
ensp
ENSRNOP00065022170
resolver
enst
ENSRNOT00000012942
resolver
enst
ENSRNOT00055041917
resolver
enst
ENSRNOT00060004171
resolver
enst
ENSRNOT00065028054
resolver
genesymbol
Cybrd1
resolver
genesymbol_syn
Dcytb
resolver
uniprot_entry
CYBR1_RAT
resolver
amino_acid_sequence
MAMEGYRGFLGLLVSALLVGFLSVIFVLIWVLHFREGLGWDGGALEFNWHPVLAVTGFVFIQGIAIIVYRLPWTWKCSKFLMKSIHAGLNAVAAILAIISVVAVFDYHNVRKIPHMYSLHSWVGLTVLILYIQQLVVGFFIFLLPWAPPSLRAIVMPIHVYSGLLLFGTVIATVLMGVTEKLFFVLKNPSYHSFPPEGVFTNTLGLLILVFGALIFWIVTRPQWKRPREPGSIPLQLNGGNADGMEGAIAISSAHNMDAADAELSSEGAARKRTLGLVDTGQRSTM
uniprot
proteins
ec_number
7.2.1.3
uniprot
proteins
function
FUNCTION: Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes. It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood. May also act as a ferrireductase in airway epithelial cells (By similarity). May also function as a cupric transmembrane reductase (By similarity). {ECO:0000250|UniProtKB:Q53TN4, ECO:0000250|UniProtKB:Q925G2}.
uniprot
proteins
mass_dalton
31519
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16510471
uniprot
proteins
pubmed
17627967
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
286
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q53TN4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}. Apical cell membrane {ECO:0000250|UniProtKB:Q53TN4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}. Note=Localized at the brush border of duodenal cells. {ECO:0000250|UniProtKB:Q53TN4}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..32; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q53TN4"; TRANSMEM 48..69; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q53TN4"; TRANSMEM 79..105; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q53TN4"; TRANSMEM 119..144; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q53TN4"; TRANSMEM 152..179; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q53TN4"; TRANSMEM 198..222; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q53TN4
uniprot
proteins