KCNA10
entrez
3744
canonical
uniprot
Q16322
canonical
ensembl
ENSG00000143105
resolver
ensp
ENSP00000358786
resolver
enst
ENST00000369771
resolver
genesymbol
KCNA10
resolver
hgnc
HGNC:6219
resolver
uniprot_entry
KCA10_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: The channel activity is up-regulated by cAMP. {ECO:0000269|PubMed:12060596}.
uniprot
proteins
amino_acid_sequence
MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKSRK
uniprot
proteins
function
FUNCTION: Voltage-gated potassium ion channel that mediates K(+) permeability of excitable membranes. When opened in response to the voltage difference across the membrane, KCNA10 channel selectively allows the flow of potassium ions across the membrane down their electrochemical gradient. {ECO:0000269|PubMed:10836990}.
uniprot
proteins
mass_dalton
57785
uniprot
proteins
protein_family
A (Shaker) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv1.8/KCNA10 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10836990
uniprot
proteins
pubmed
12060596
uniprot
proteins
pubmed
12444201
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
9177773
uniprot
proteins
sequence_length
511
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 218..238; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 271..292; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 303..323; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 339..358; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 375..395; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 436..456; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins