GDPD4
entrez
220032
canonical
uniprot
Q6W3E5
canonical
ensembl
ENSG00000178795
resolver
ensp
ENSP00000320815
resolver
ensp
ENSP00000365390
resolver
genesymbol
GDPD4
resolver
genesymbol_syn
GDE6
resolver
genesymbol_syn
UGPQ
resolver
hgnc
HGNC:24849
resolver
uniprot
Q7Z5B0
resolver
uniprot_entry
GDE6_HUMAN
resolver
uniprot_sec
Q7Z5B0
resolver
amino_acid_sequence
MLLFLWIETSSEYFNFDWVTFLGTGYWFFWSIFILSLARILTAYSSLLLLLGFLLLWERIELYLHLCHKILILLVILLCVILMFIICKFWKERWLVAGLSMQIFAPYVHLVSITVMVILFWPVAFYVACLEREVRMRRYRMTHSEKKRLKQCNVITRLRGLQVPVGLPFLLILLGLYLMPLGIYSPCIQEKENLGPKPTIFGHRGAPMLGPENTMMSFEKAVEHGAHGLETDIHLSYDHVPFLMHDFDLKRTTNIGEVQPESACENPAFFNWDFLSTLNAGKWFVKPELRPFYNMKPLSEADKERARNQSIPTLADLLTLAEKERKFVIFDLHRPPPKHPLRHTFVRQVVSVILASKIEQHLIFWLPAHDRQYVRSVAPGFQHVGRLVSIETLAKNNISIINVDYKKLFPNGLRDYKAANIHINVYTVNEPWLFSLAWCSRINSVTTDNIGLLSQLDHPHFFMTPKFYVFMWLLADIISVLFIVAIFCFHWRRETEKEKLFETSSTRTDTQSGNLHIAMKPPVRVVEGPWTLAALYPALPKSGKEHQGHFNFAAPSKKLLPIKNAVTPLKPGKHEIQPPMPTVVFELTQAPTRQATSEATFQTTLPTLKVDKPTMPSIEVPYP
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
function
FUNCTION: Ecto-phospholipase that cleaves the phosphodiester bond in the glycosylphosphatidylinositol (GPI) anchor of TRABD2A and TRABD2B, releasing them from the plasma membrane. The release in the extracellular space inactivates these metalloproteases involved in the negative regulation of Wnt signaling. {ECO:0000269|PubMed:35182431}.
uniprot
proteins
mass_dalton
71996
uniprot
proteins
protein_family
Glycerophosphoryl diester phosphodiesterase family
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
35182431
uniprot
proteins
sequence_length
623
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:35182431}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 70..90; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 469..489; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins