PTPRN2
entrez
5799
canonical
uniprot
Q92932
canonical
ensembl
ENSG00000155093
resolver
ensp
ENSP00000374064
resolver
ensp
ENSP00000374067
resolver
ensp
ENSP00000374069
resolver
ensp
ENSP00000387114
resolver
ensp
ENSP00000786208
resolver
enst
ENST00000409483
resolver
genesymbol
PTPRN2
resolver
genesymbol_syn
KIAA0387
resolver
hgnc
HGNC:9677
resolver
uniprot
E7EM83
resolver
uniprot
E9PC57
resolver
uniprot
I6L9F8
resolver
uniprot
Q8N4I5
resolver
uniprot
Q92662
resolver
uniprot
Q9Y4F8
resolver
uniprot
Q9Y4I6
resolver
uniprot_entry
E7EM83_HUMAN
resolver
uniprot_entry
I6L9F8_HUMAN
resolver
uniprot_entry
PTPR2_HUMAN
resolver
uniprot_sec
E9PC57
resolver
uniprot_sec
Q8N4I5
resolver
uniprot_sec
Q92662
resolver
uniprot_sec
Q9Y4F8
resolver
uniprot_sec
Q9Y4I6
resolver
amino_acid_sequence
MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRLGCLLEEGLCGASEACVNDGVFGRCQKVPAMDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRPEASSPARPSKHSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEGDDRFSESILTYVAHTSALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRHHLMAALSAYAAQRPPAPPGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSSTGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGESGEQADGPKATLRGDSFPDDGVQDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARPLDMERKKSEHPESSLSSEEETAGVENVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGPSKEEQSLPAGAQEALSDGLQLEVQPSEEEARGYIVTDRDPLRPEEGRRLVEDVARLLQVPSSAFADVEVLGPAVTFKVSANVQNVTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKLKFLPPQAEQEDSTKFIALTLVSLACILGVLLASGLIYCLRHSSQHRLKEKLSGLGGDPGADATAAYQELCRQRMATRPPDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQSNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ
uniprot
proteins
disease_involvement
DISEASE: Note=Autoantigen in insulin-dependent diabetes mellitus (IDDM). {ECO:0000269|PubMed:8637868, ECO:0000269|PubMed:8798755, ECO:0000269|PubMed:8878534}.
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolysis of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550). {ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475, ECO:0000269|PubMed:26620550}.
uniprot
proteins
mass_dalton
111271
uniprot
proteins
mutagenesis
MUTAGEN 945; /note="C->A: No effect to increase invasion, migration, and metastatic lung colonization in mice breast cancer model."; /evidence="ECO:0000269|PubMed:26620550"; MUTAGEN 945; /note="C->S: Loss of activity.
uniprot
proteins
post_translational_modification
PTM: Subject to proteolytic cleavage at multiple sites. {ECO:0000250|UniProtKB:P80560}.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 8 subfamily
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19167335
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
25421040
uniprot
proteins
pubmed
26620550
uniprot
proteins
pubmed
8637868
uniprot
proteins
pubmed
8798755
uniprot
proteins
pubmed
8878534
uniprot
proteins
pubmed
8954911
uniprot
proteins
pubmed
9205841
uniprot
proteins
sequence_length
1015
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P80560}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P80560}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P80560}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P80560}. Note=Predominantly found on dense-core secretory granules. Sorting to secretory granules in part is dependent of the N-terminal propeptide domain of the precursor and its interaction with CPE (By similarity). Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles involving clathrin-dependent AP2-mediated endocytosis. Recycled via STX6- but not TTTGN1/TGN38-containing compartments (By similarity). {ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475}.; SUBCELLULAR LOCATION: [IA-2beta60]: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 616..636; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins