SLC34A2
entrez
10568
canonical
uniprot
O95436
canonical
ensembl
ENSG00000157765
resolver
ensp
ENSP00000371483
resolver
ensp
ENSP00000423021
resolver
ensp
ENSP00000425501
resolver
genesymbol
SLC34A2
resolver
hgnc
HGNC:11020
resolver
uniprot
A5PL17
resolver
uniprot
Q8N2K2
resolver
uniprot
Q8WYA9
resolver
uniprot
Q9P0V7
resolver
uniprot_entry
NPT2B_HUMAN
resolver
uniprot_sec
A5PL17
resolver
uniprot_sec
Q8N2K2
resolver
uniprot_sec
Q8WYA9
resolver
uniprot_sec
Q9P0V7
resolver
amino_acid_sequence
MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSLKPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVKAPETFDNITISREAQGEVPASDSKTECTAL
uniprot
proteins
disease_involvement
DISEASE: Pulmonary alveolar microlithiasis (PULAM) [MIM:265100]: Rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early-onset or rapid progression are rare. A 'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance. {ECO:0000269|PubMed:16960801}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=A chromosomal aberration involving SLC34A2 is found in a glioblastoma multiforme cell line U-118MG. Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity. {ECO:0000269|PubMed:12661006}.
uniprot
proteins
function
FUNCTION: Involved in actively transporting phosphate into cells via Na(+) cotransport. {ECO:0000269|PubMed:10329428}.
uniprot
proteins
mass_dalton
75759
uniprot
proteins
protein_family
SLC34A transporter family
uniprot
proteins
pubmed
10329428
uniprot
proteins
pubmed
10610722
uniprot
proteins
pubmed
11171583
uniprot
proteins
pubmed
12661006
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16960801
uniprot
proteins
sequence_length
690
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9DBP0}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of enterocytes. {ECO:0000250|UniProtKB:Q9DBP0}.
uniprot
proteins
transmembrane_region
TRANSMEM 101..121; /note="Helical; Name=M1"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical; Name=M2"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical; Name=M3"; /evidence="ECO:0000255"; TRANSMEM 363..383; /note="Helical; Name=M4"; /evidence="ECO:0000255"; TRANSMEM 408..428; /note="Helical; Name=M5"; /evidence="ECO:0000255"; TRANSMEM 486..506; /note="Helical; Name=M6"; /evidence="ECO:0000255"; TRANSMEM 526..546; /note="Helical; Name=M7"; /evidence="ECO:0000255"; TRANSMEM 553..573; /note="Helical; Name=M8"; /evidence="ECO:0000255
uniprot
proteins