Rhno1
entrez
297627
canonical
uniprot
Q6AY26
canonical
ensembl
ENSRNOG00000028517
resolver
ensembl
ENSRNOG00055011058
resolver
ensembl
ENSRNOG00060018034
resolver
ensembl
ENSRNOG00065033678
resolver
ensp
ENSRNOP00000036772
resolver
ensp
ENSRNOP00055015095
resolver
ensp
ENSRNOP00060025048
resolver
ensp
ENSRNOP00065047637
resolver
enst
ENSRNOT00000039086
resolver
enst
ENSRNOT00055018735
resolver
enst
ENSRNOT00060030940
resolver
enst
ENSRNOT00065057852
resolver
genesymbol
Rhno1
resolver
uniprot_entry
RHNO1_RAT
resolver
amino_acid_sequence
MPPRKRRRQCQKAQLLFHQQPLEGPKPHYESHQQPITHTVQVPSKPIDQSTITSWVLPQFDTAAESRFPTHRKHHRDQARHPTRRSTCKFPRLTFESPESSSSETLLLSNREQLQNSEKDAPRRPLVPLFSPQSCGELSVHVPQSLPHVFMPPDIQTPGSSVREDPISPDQKENSLPSCILGPRTPRTPEPGPVLVKDTPEEKYGIKVTWRRRRHLFAYLKERGKLDKSQFLVKT
uniprot
proteins
function
FUNCTION: Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis. MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair double-strand breaks in DNA that originate in S-phase. Accumulates in M-phase; following phosphorylation by PLK1, interacts with POLQ, enabling its recruitment to double-strand breaks for subsequent repair. Also involved in the DNA damage response (DDR) signaling in response to genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation. {ECO:0000250|UniProtKB:Q9BSD3}.
uniprot
proteins
mass_dalton
27070
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-50 by PLK1, promoting interaction with polymerase theta (POLQ). {ECO:0000250|UniProtKB:Q9BSD3}.; PTM: Ubiquitinated and degraded by the APC/C complex upon mitotic exit. {ECO:0000250|UniProtKB:Q9BSD3}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BSD3}. Chromosome {ECO:0000250|UniProtKB:Q9BSD3}. Note=Localizes to sites of DNA damage in a H2AX-independent manner. {ECO:0000250|UniProtKB:Q9BSD3}.
uniprot
proteins