Nrp1
entrez
246331
canonical
uniprot
Q9QWJ9
canonical
ensembl
ENSRNOG00000010744
resolver
ensembl
ENSRNOG00055005353
resolver
ensembl
ENSRNOG00060005340
resolver
ensembl
ENSRNOG00065018438
resolver
ensp
ENSRNOP00000014492
resolver
ensp
ENSRNOP00000075034
resolver
ensp
ENSRNOP00000082340
resolver
ensp
ENSRNOP00055006532
resolver
ensp
ENSRNOP00060006780
resolver
ensp
ENSRNOP00065024713
resolver
enst
ENSRNOT00000080465
resolver
enst
ENSRNOT00000108605
resolver
enst
ENSRNOT00055008628
resolver
enst
ENSRNOT00060008991
resolver
enst
ENSRNOT00065031030
resolver
genesymbol
Nrp1
resolver
uniprot
A0A8I5ZTD9
resolver
uniprot
A0A8L2R9S2
resolver
uniprot_entry
A0A8I5ZTD9_RAT
resolver
uniprot_entry
A0A8L2R9S2_RAT
resolver
uniprot_entry
NRP1_RAT
resolver
amino_acid_sequence
MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGVFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWITLKEGNKAIIFQGNTNPTDVVFGVFPKPLITRFVRIKPASWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQGDRNWMPENIRLVTSRTGWALPPSPHPYINEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRAFTPLSTRFIRIYPERATHSGLGLRMELLGCEVEVPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWRVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLHYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHIPQEDCAKPTDLDKKNTEIKIDETGSTPGYEEGKGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA
uniprot
proteins
function
FUNCTION: Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity). {ECO:0000250|UniProtKB:O14786, ECO:0000250|UniProtKB:P97333}.
uniprot
proteins
mass_dalton
103082
uniprot
proteins
protein_family
Neuropilin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17405859
uniprot
proteins
pubmed
28270793
uniprot
proteins
pubmed
9288754
uniprot
proteins
sequence_length
922
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250|UniProtKB:O14786}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:O14786}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:O14786}.
uniprot
proteins
transmembrane_region
TRANSMEM 856..880; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins