Ptgr1
entrez
192227
canonical
uniprot
P97584
canonical
ensembl
ENSRNOG00000015072
resolver
ensp
ENSRNOP00000020335
resolver
genesymbol
Ptgr1
resolver
genesymbol_syn
Dig1
resolver
genesymbol_syn
Ltb4dh
resolver
uniprot
Q5EBD3
resolver
uniprot_entry
PTGR1_RAT
resolver
uniprot_sec
Q5EBD3
resolver
amino_acid_sequence
MVQAKTWTLKKHFEGFPTDSNFELRTTELPPLNNGEVLLEALFLSVDPYMRVAAKKLKEGDSMMGEQVARVVESKNSAFPTGTIVVALLGWTSHSISDGNGLRKLPAEWPDKLPLSLALGTVGMPGLTAYFGLLDICGLKGGETVLVNAAAGAVGSVVGQIAKLKGCKVVGTAGSDEKVAYLKKLGFDVAFNYKTVKSLEEALRTASPDGYDCYFDNVGGEFSNTVILQMKTFGRIAICGAISQYNRTGPCPPGPSPEVIIYQQLRMEGFIVTRWQGEVRQKALTDLMNWVSEGKIRYHEYITEGFEKMPAAFMGMLKGDNLGKTIVKA
uniprot
proteins
ec_number
1.3.1.48
uniprot
proteins
ec_number
1.3.1.74
uniprot
proteins
function
FUNCTION: NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (By similarity). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (By similarity) (PubMed:11524419). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). Plays a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:11524419). Inactivates 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (PubMed:11524419). {ECO:0000250|UniProtKB:Q14914, ECO:0000250|UniProtKB:Q29073, ECO:0000269|PubMed:11524419}.
uniprot
proteins
mass_dalton
35718
uniprot
proteins
protein_family
NADP-dependent oxidoreductase L4BD family
uniprot
proteins
pubmed
11524419
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8968041
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q29073}.
uniprot
proteins