TAF6
entrez
6878
canonical
uniprot
P49848
canonical
ensembl
ENSG00000106290
resolver
ensp
ENSP00000344537
resolver
ensp
ENSP00000389575
resolver
ensp
ENSP00000399982
resolver
ensp
ENSP00000508788
resolver
ensp
ENSP00000509041
resolver
ensp
ENSP00000509320
resolver
ensp
ENSP00000509335
resolver
ensp
ENSP00000509741
resolver
ensp
ENSP00000509821
resolver
ensp
ENSP00000787367
resolver
genesymbol
TAF6
resolver
genesymbol_syn
TAF2E
resolver
genesymbol_syn
TAFII70
resolver
hgnc
HGNC:11540
resolver
uniprot
A4D2B2
resolver
uniprot
A4D2B3
resolver
uniprot
B4DT11
resolver
uniprot
D6W5U2
resolver
uniprot
Q6AI29
resolver
uniprot_entry
TAF6_HUMAN
resolver
uniprot_sec
A4D2B2
resolver
uniprot_sec
A4D2B3
resolver
uniprot_sec
B4DT11
resolver
uniprot_sec
D6W5U2
resolver
uniprot_sec
Q6AI29
resolver
amino_acid_sequence
MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVSYRIKEIAQDALKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGRELYFYEEKEVDLSDIINTPLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAEATEPLKSAKPGQEEDGPLKGKGQGATTADGKGKEKKAPPLLEGAPLRLKPRSIHELSVEQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRAEFGSLGPLLCSQVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAAAPPQPSPPPTKFIVMSSSSSAPSTQQVLSLSTSAPGSGSTTTSPVTTTVPSVQPIVKLVSTATTAPPSTAPSGPGSVQKYIVVSLPPTGEGKGGPTSHPSPVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGTPKANGSQPNSGSPQPAP
uniprot
proteins
disease_involvement
DISEASE: Alazami-Yuan syndrome (ALYUS) [MIM:617126]: An autosomal recessive syndrome reminiscent of Cornelia de Lange syndrome and characterized by delayed psychomotor development with intellectual disability, hypotonia, microcephaly, short stature, poor speech, and dysmorphic features. {ECO:0000269|PubMed:25558065, ECO:0000269|PubMed:25574841}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473). {ECO:0000269|PubMed:33795473}.; FUNCTION: [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700). {ECO:0000269|PubMed:11583621, ECO:0000269|PubMed:18628956, ECO:0000269|PubMed:20096117, ECO:0000269|PubMed:29358700}.
uniprot
proteins
mass_dalton
72668
uniprot
proteins
post_translational_modification
PTM: [Isoform 4]: In cells undergoing apoptosis, cleaved in a caspase-dependent manner to produce a 40 kDa product. {ECO:0000269|PubMed:11583621}.
uniprot
proteins
protein_family
TAF6 family
uniprot
proteins
pubmed
11583621
uniprot
proteins
pubmed
12601814
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15601843
uniprot
proteins
pubmed
15960975
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18628956
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20096117
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25025302
uniprot
proteins
pubmed
25558065
uniprot
proteins
pubmed
25574841
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29358700
uniprot
proteins
pubmed
33795473
uniprot
proteins
pubmed
7667268
uniprot
proteins
pubmed
8262073
uniprot
proteins
sequence_length
677
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus {ECO:0000269|PubMed:18628956}.
uniprot
proteins