Tmprss11d
entrez
231382
canonical
uniprot
Q8VHK8
canonical
ensembl
ENSMUSG00000061259
resolver
ensp
ENSMUSP00000031175
resolver
genesymbol
Tmprss11d
resolver
genesymbol_syn
Mat
resolver
uniprot
Q7TNX3
resolver
uniprot
Q8VDV1
resolver
uniprot_entry
TM11D_MOUSE
resolver
uniprot_sec
Q7TNX3
resolver
uniprot_sec
Q8VDV1
resolver
amino_acid_sequence
MYRPRPMLSPSRFFTPFAVAFVVIITVGLLAMMAGLLIHFLAFDKKAYFYHSSFQILNVEYTEALNSPATHEYRTLSERIEAMITDEFRGSSLKSEFIRTHVVKLRKEGTGVVADVVMKFRSSKRNNRKVMKTRIQSVLRRLSSSGNLEIAPSNEITSLTDQDTENVLTQECGARPDLITLSEERIIGGMQAEPGDWPWQVSLQLNNVHHCGGALISNMWVLTAAHCFKSYPNPQYWTATFGVSTMSPRLRVRVRAILAHDGYSSVTRDNDIAVVQLDRSVAFSRNIHRVCLPAATQNIIPGSVAYVTGWGSLTYGGNAVTNLRQGEVRIISSEECNTPAGYSGSVLPGMLCAGMRSGAVDACQGDSGGPLVQEDSRRLWFVVGIVSWGYQCGLPNKPGVYTRVTAYRNWIRQQTGI
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides (By similarity). Plays a role in the proteolytic processing of ACE2. Isoform 2 may play a key role in regulating adrenal proliferation by specifically cleaving N-POMC. {ECO:0000250, ECO:0000269|PubMed:24227843}.
uniprot
proteins
mass_dalton
46254
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
14691009
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24227843
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Transmembrane protease serine 11D catalytic chain]: Secreted {ECO:0000250}. Note=Activated by cleavage and secreted. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins