Aldob
entrez
230163
canonical
uniprot
Q91Y97
canonical
ensembl
ENSMUSG00000028307
resolver
ensp
ENSMUSP00000029987
resolver
enst
ENSMUST00000029987
resolver
genesymbol
Aldob
resolver
genesymbol_syn
Aldo2
resolver
uniprot
Q3TJ66
resolver
uniprot
Q3UER1
resolver
uniprot
Q8K034
resolver
uniprot
Q91W73
resolver
uniprot_entry
ALDOB_MOUSE
resolver
uniprot_entry
Q3TJ66_MOUSE
resolver
uniprot_entry
Q3UER1_MOUSE
resolver
uniprot_sec
Q8K034
resolver
uniprot_sec
Q91W73
resolver
amino_acid_sequence
MAHRFPALTPEQKKELSEIAQRIVANGKGILAADESVGTMGNRLQRIKVENTEENRRQFRELLFSVDNSISQSIGGVILFHETLYQKDSQGNLFRNVLKEKGIVVGIKLDQGGAPLAGTNKETTIQGLDGLSERCAQYKKDGVDFGKWRAVLRIADQCPSSLAIQENANALARYASICQQNGLVPIVEPEVLPDGDHDLEHCQYVSEKVLAAVYKALNDHHVYLEGTLLKPNMVTAGHACTKKYTPEQVAMATVTALHRTVPAAVPGICFLSGGMSEEDATLNLNAINRCPLPRPWKLSFSYGRALQASALAAWGGKAANKKATQEAFMKRAMANCQAAQGQYVHTGSSGAAATQSLFTASYTY
uniprot
proteins
ec_number
4.1.2.13
uniprot
proteins
function
FUNCTION: Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:25637246). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041). {ECO:0000269|PubMed:25637246, ECO:0000269|PubMed:35122041}.
uniprot
proteins
mass_dalton
39507
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. {ECO:0000305|PubMed:25637246}.; PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. {ECO:0000305|PubMed:25637246}.; PATHWAY: Carbohydrate metabolism; fructose metabolism. {ECO:0000269|PubMed:25637246}.
uniprot
proteins
protein_family
Class I fructose-bisphosphate aldolase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
25637246
uniprot
proteins
pubmed
35122041
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P05062}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:P05062}.
uniprot
proteins