PTPN1
entrez
5770
canonical
uniprot
P18031
canonical
ensembl
ENSG00000196396
resolver
ensp
ENSP00000360683
resolver
ensp
ENSP00000437732
resolver
enst
ENST00000371621
resolver
enst
ENST00000541713
resolver
genesymbol
PTPN1
resolver
genesymbol_syn
PTP1B
resolver
hgnc
HGNC:9642
resolver
uniprot
A8K3M3
resolver
uniprot
B4DSN5
resolver
uniprot
F6WA77
resolver
uniprot
Q5TGD8
resolver
uniprot
Q9BQV9
resolver
uniprot
Q9NQQ4
resolver
uniprot_entry
A8K3M3_HUMAN
resolver
uniprot_entry
B4DSN5_HUMAN
resolver
uniprot_entry
F6WA77_HUMAN
resolver
uniprot_entry
PTN1_HUMAN
resolver
uniprot_sec
Q5TGD8
resolver
uniprot_sec
Q9BQV9
resolver
uniprot_sec
Q9NQQ4
resolver
amino_acid_sequence
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.
uniprot
proteins
mass_dalton
49967
uniprot
proteins
mutagenesis
MUTAGEN 50; /note="S->A,D: No phosphorylation."; /evidence="ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:11579209"; MUTAGEN 181; /note="D->A: Substrate-trapping mutant."; /evidence="ECO:0000269|PubMed:22169477"; MUTAGEN 215; /note="C->S: Catalytically inactive mutant; abolishes sulfhydration."; /evidence="ECO:0000269|PubMed:22169477
uniprot
proteins
post_translational_modification
PTM: Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a sulfenamide cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction. {ECO:0000269|PubMed:12802338, ECO:0000269|PubMed:12802339}.; PTM: Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50. {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:11579209, ECO:0000269|PubMed:8491187, ECO:0000269|PubMed:9355745}.; PTM: S-nitrosylation of Cys-215 inactivates the enzyme activity. {ECO:0000269|PubMed:22169477}.; PTM: Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity.
uniprot
proteins
protein_family
Non-receptor class 1 subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
10480872
uniprot
proteins
pubmed
11579209
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12802338
uniprot
proteins
pubmed
12802339
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15919835
uniprot
proteins
pubmed
1739967
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18819921
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21135139
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
2157211
uniprot
proteins
pubmed
2164224
uniprot
proteins
pubmed
21707536
uniprot
proteins
pubmed
22169477
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2546149
uniprot
proteins
pubmed
29043977
uniprot
proteins
pubmed
8128219
uniprot
proteins
pubmed
8491187
uniprot
proteins
pubmed
9355745
uniprot
proteins
pubmed
9391040
uniprot
proteins
pubmed
9553104
uniprot
proteins
pubmed
9922143
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Peripheral membrane protein {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Cytoplasmic side {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}. Note=Interacts with EPHA3 at the cell membrane.
uniprot
proteins