CYP2C9
entrez
1559
canonical
uniprot
P11712
canonical
ensembl
ENSG00000138109
resolver
ensp
ENSP00000260682
resolver
genesymbol
CYP2C9
resolver
genesymbol_syn
CYP2C10
resolver
hgnc
HGNC:2623
resolver
uniprot
P11713
resolver
uniprot
Q16756
resolver
uniprot
Q16872
resolver
uniprot
Q5VX92
resolver
uniprot
Q6IRV8
resolver
uniprot
Q8WW80
resolver
uniprot_entry
CP2C9_HUMAN
resolver
uniprot_sec
P11713
resolver
uniprot_sec
Q16756
resolver
uniprot_sec
Q16872
resolver
uniprot_sec
Q5VX92
resolver
uniprot_sec
Q6IRV8
resolver
uniprot_sec
Q8WW80
resolver
amino_acid_sequence
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
ec_number
1.14.14.51
uniprot
proteins
ec_number
1.14.14.52
uniprot
proteins
ec_number
1.14.14.53
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids (PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599, PubMed:7574697, PubMed:9435160, PubMed:9866708). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599, PubMed:7574697, PubMed:9435160, PubMed:9866708). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:15766564, PubMed:19965576, PubMed:7574697, PubMed:9866708). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA) (PubMed:9435160, PubMed:9866708). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031). {ECO:0000269|PubMed:11950794, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15766564, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:25994031, ECO:0000269|PubMed:7574697, ECO:0000269|PubMed:9435160, ECO:0000269|PubMed:9866708}.
uniprot
proteins
mass_dalton
55628
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; arachidonate metabolism. {ECO:0000269|PubMed:15766564, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:7574697, ECO:0000269|PubMed:9435160}.; PATHWAY: Steroid metabolism; cholesterol metabolism. {ECO:0000269|PubMed:21576599}.; PATHWAY: Terpene metabolism; (4R)-limonene degradation. {ECO:0000269|PubMed:11950794}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10739176
uniprot
proteins
pubmed
11455026
uniprot
proteins
pubmed
11926893
uniprot
proteins
pubmed
11950794
uniprot
proteins
pubmed
12861225
uniprot
proteins
pubmed
12865317
uniprot
proteins
pubmed
1445376
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15469410
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15766564
uniprot
proteins
pubmed
1857342
uniprot
proteins
pubmed
19965576
uniprot
proteins
pubmed
21451434
uniprot
proteins
pubmed
21576599
uniprot
proteins
pubmed
23582453
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24956244
uniprot
proteins
pubmed
25994031
uniprot
proteins
pubmed
2827463
uniprot
proteins
pubmed
2963808
uniprot
proteins
pubmed
3032244
uniprot
proteins
pubmed
3079764
uniprot
proteins
pubmed
3196692
uniprot
proteins
pubmed
3243766
uniprot
proteins
pubmed
3697070
uniprot
proteins
pubmed
7574697
uniprot
proteins
pubmed
8215449
uniprot
proteins
pubmed
8809086
uniprot
proteins
pubmed
8946475
uniprot
proteins
pubmed
9110362
uniprot
proteins
pubmed
9435160
uniprot
proteins
pubmed
9866708
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:21576599}; Peripheral membrane protein.
uniprot
proteins