Gimap5
entrez
317757
canonical
uniprot
Q8BWF2
canonical
ensembl
ENSMUSG00000043505
resolver
ensp
ENSMUSP00000056820
resolver
enst
ENSMUST00000055558
resolver
genesymbol
Gimap5
resolver
genesymbol_syn
Ian4l1
resolver
genesymbol_syn
Ian5
resolver
genesymbol_syn
Imap3
resolver
uniprot
Q501L7
resolver
uniprot
Q549X3
resolver
uniprot_entry
GIMA5_MOUSE
resolver
uniprot_sec
Q501L7
resolver
uniprot_sec
Q549X3
resolver
amino_acid_sequence
MEHLQKSTYGTIVQGPEAHCVQESSCLRILLVGKSGCGKSATGNSILRRPAFQSRLRGQSVTRTSQAETGTWEGRSILVVDTPPIFESKAQNQDMDKDIGDCYLLCAPGPHVLLLVTQLGRFTAEDAMAVRMVKEVFGVGVMRHMIVLFTRKEDLEEKSLEEFVTHTDNRSLRSLTQECGRRYCAFNNRASGEEQQGQLAELMALVRRLEQECEGSFHSNDLFLHAEALLREGYSVHQEAYRCYLAKVRQEVEKQRRELEEQEGSWIAKMICTVKSCWSSHTAACALLIVLGLTLLTTFINLCISRCK
uniprot
proteins
function
FUNCTION: Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (PubMed:16509771). Inhibitor of GSK3A. May act by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of bone marrow hematopoietic stem cells, as well as of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (PubMed:18796632, PubMed:21502331). May promote the survival of mature T lymphocytes upon cytokine withdrawal (PubMed:16509771). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (PubMed:25808953). Is a regulator of liver endothelial cell homeostasis (PubMed:33956074). {ECO:0000250|UniProtKB:Q8K3L6, ECO:0000269|PubMed:16509771, ECO:0000269|PubMed:18796632, ECO:0000269|PubMed:21502331, ECO:0000269|PubMed:25808953, ECO:0000269|PubMed:29382851, ECO:0000269|PubMed:33956074}.
uniprot
proteins
mass_dalton
34653
uniprot
proteins
protein_family
AIG1/Toc34/Toc159-like paraseptin GTPase family
uniprot
proteins
protein_family
IAN subfamily
uniprot
proteins
protein_family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16509771
uniprot
proteins
pubmed
18796632
uniprot
proteins
pubmed
21487483
uniprot
proteins
pubmed
21502331
uniprot
proteins
pubmed
25808953
uniprot
proteins
pubmed
29382851
uniprot
proteins
pubmed
33956074
uniprot
proteins
sequence_length
308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:33956074}. Lysosome membrane {ECO:0000269|PubMed:21487483, ECO:0000269|PubMed:29382851}; Single-pass type IV membrane protein {ECO:0000305}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:21487483}; Single-pass type IV membrane protein {ECO:0000305}. Endosome membrane {ECO:0000250|UniProtKB:Q8K3L6}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8K3L6}.
uniprot
proteins
transmembrane_region
TRANSMEM 284..304; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins