SNX3
entrez
8724
canonical
uniprot
O60493
canonical
ensembl
ENSG00000112335
resolver
ensp
ENSP00000230085
resolver
ensp
ENSP00000296991
resolver
ensp
ENSP00000401779
resolver
ensp
ENSP00000648132
resolver
genesymbol
SNX3
resolver
hgnc
HGNC:11174
resolver
uniprot
A8K0B1
resolver
uniprot
E1P5E4
resolver
uniprot
E1P5E5
resolver
uniprot
O60718
resolver
uniprot
Q4TT29
resolver
uniprot
Q4TT31
resolver
uniprot
Q5JXJ7
resolver
uniprot
Q5JXJ8
resolver
uniprot
Q96AP9
resolver
uniprot
Q9C0J5
resolver
uniprot
Q9NU45
resolver
uniprot_entry
SNX3_HUMAN
resolver
uniprot_sec
A8K0B1
resolver
uniprot_sec
E1P5E4
resolver
uniprot_sec
E1P5E5
resolver
uniprot_sec
O60718
resolver
uniprot_sec
Q4TT29
resolver
uniprot_sec
Q4TT31
resolver
uniprot_sec
Q5JXJ7
resolver
uniprot_sec
Q5JXJ8
resolver
uniprot_sec
Q96AP9
resolver
uniprot_sec
Q9C0J5
resolver
uniprot_sec
Q9NU45
resolver
amino_acid_sequence
MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving SNX3 has been found in patients with syndromic microphthalmia. Translocation t(6;13)(q21;q12). {ECO:0000269|PubMed:12471201}.
uniprot
proteins
function
FUNCTION: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282, PubMed:30213940). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). Involved in regulation of neurite outgrowth in primary neurons (By similarity). Required for trafficking of WLS to the early endosome for recycling which promotes both canonical and non-canonical WNT signaling and is essential for neural tube closure (By similarity). {ECO:0000250|UniProtKB:O70492, ECO:0000269|PubMed:11433298, ECO:0000269|PubMed:18767904, ECO:0000269|PubMed:21725319, ECO:0000269|PubMed:23237080, ECO:0000269|PubMed:24344282, ECO:0000305|PubMed:21725319}.; FUNCTION: (Microbial infection) In the case of Salmonella enterica infection, plays a role in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs. {ECO:0000269|PubMed:20482551}.
uniprot
proteins
mass_dalton
18762
uniprot
proteins
mutagenesis
MUTAGEN 9..10; /note="RR->AA: Loss of VPS35 binding."; /evidence="ECO:0000269|PubMed:30213940"; MUTAGEN 22..28; /note="Missing: Loss of VPS35 binding."; /evidence="ECO:0000269|PubMed:30213940"; MUTAGEN 22; /note="Y->A: Loss of VPS35 binding."; /evidence="ECO:0000269|PubMed:30213940"; MUTAGEN 28; /note="F->A: Abolishes interaction with retromer cargo-selective subcomplex VPS26A:VPS29:VPS35; when associated with A-30 and A-32."; /evidence="ECO:0000269|PubMed:24344282"; MUTAGEN 30..32; /note="EID->TIR: Loss of VPS35 binding."; /evidence="ECO:0000269|PubMed:30213940"; MUTAGEN 30; /note="E->A: Abolishes interaction with retromer cargo-selective subcomplex VPS26A:VPS29:VPS35; when associated with A-28 and A-32."; /evidence="ECO:0000269|PubMed:24344282"; MUTAGEN 32; /note="D->A: Abolishes interaction with retromer cargo-selective subcomplex VPS26A:VPS29:VPS35; when associated with A-28 and A-30."; /evidence="ECO:0000269|PubMed:24344282"; MUTAGEN 50; /note="E->K: Loss of VPS35 binding."; /evidence="ECO:0000269|PubMed:30213940"; MUTAGEN 69..71; /note="RRY->AAA: Abolishes binding to phosphatidylinositol 3-phosphate."; /evidence="ECO:0000269|PubMed:11433298"; MUTAGEN 71; /note="Y->A: Abolishes binding to phosphatidylinositol 3-phosphate."; /evidence="ECO:0000269|PubMed:11433298"; MUTAGEN 75; /note="E->A: Increases VPS35 binding."; /evidence="ECO:0000269|PubMed:30213940"; MUTAGEN 84..86; /note="ESK->NAG: Decreases VPS35 binding."; /evidence="ECO:0000269|PubMed:30213940"; MUTAGEN 99..110; /note="Missing: Increases VPS35 binding."; /evidence="ECO:0000269|PubMed:30213940"; MUTAGEN 154; /note="Y->A: Decreases VPS35 binding."; /evidence="ECO:0000269|PubMed:30213940"; MUTAGEN 156; /note="P->A: Decreases VPS35 binding."; /evidence="ECO:0000269|PubMed:30213940"; MUTAGEN 160; /note="R->A: Loss of VPS35 binding."; /evidence="ECO:0000269|PubMed:30213940
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP10 (By similarity). {ECO:0000250|UniProtKB:O70492}.
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
11433298
uniprot
proteins
pubmed
12471201
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17622474
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18767904
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20482551
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21725319
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23237080
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24344282
uniprot
proteins
pubmed
24866125
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
30213940
uniprot
proteins
pubmed
33214242
uniprot
proteins
pubmed
9819414
uniprot
proteins
sequence_length
162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:11433298, ECO:0000269|PubMed:21725319, ECO:0000269|PubMed:30213940}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:23237080}. Note=Colocalizes to clathrin-coated endosomal vesicles morphologically distinct from retromer-decorated non-branched endosomal tubule structures (PubMed:21725319) Colocalizes with EEA1 on nascent phagosomes in dendritic cells but competes with EEA1 for binding to phagosomal membrane (PubMed:23237080). In the case of Salmonella enterica infection localizes to Salmonella-containing vacuoles (SCVs) from which SNX3-containing tubules form 30-60 minutes after infection (PubMed:20482551). {ECO:0000269|PubMed:20482551, ECO:0000269|PubMed:21725319, ECO:0000269|PubMed:23237080}.
uniprot
proteins