HDAC2
entrez
3066
canonical
uniprot
Q92769
canonical
ensembl
ENSG00000196591
resolver
ensp
ENSP00000430008
resolver
ensp
ENSP00000430432
resolver
genesymbol
HDAC2
resolver
hgnc
HGNC:4853
resolver
uniprot
B3KRS5
resolver
uniprot
B4DL58
resolver
uniprot
E1P561
resolver
uniprot
Q5SRI8
resolver
uniprot
Q5SZ86
resolver
uniprot
Q8NEH4
resolver
uniprot_entry
HDAC2_HUMAN
resolver
uniprot_sec
B3KRS5
resolver
uniprot_sec
B4DL58
resolver
uniprot_sec
E1P561
resolver
uniprot_sec
Q5SRI8
resolver
uniprot_sec
Q5SZ86
resolver
uniprot_sec
Q8NEH4
resolver
activity_regulation
ACTIVITY REGULATION: Inositol tetraphosphate (1D-myo-inositol 1,4,5,6-tetrakisphosphate) may act as an intermolecular glue between HDAC2 and N-Cor repressor complex components. {ECO:0000250|UniProtKB:O15379}.
uniprot
proteins
amino_acid_sequence
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
uniprot
proteins
ec_number
3.5.1.-
uniprot
proteins
ec_number
3.5.1.98
uniprot
proteins
function
FUNCTION: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:35044827). {ECO:0000250|UniProtKB:P70288, ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:35044827, ECO:0000269|PubMed:37137925}.
uniprot
proteins
mass_dalton
55364
uniprot
proteins
post_translational_modification
PTM: S-nitrosylated by GAPDH. In neurons, S-nitrosylation at Cys-262 and Cys-274 does not affect enzyme activity, but induces HDAC2 release from chromatin. This in turn increases acetylation of histones surrounding neurotrophin-dependent gene promoters and promotes their transcription. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching. {ECO:0000250|UniProtKB:P70288}.
uniprot
proteins
protein_family
HD type 1 subfamily
uniprot
proteins
protein_family
Histone deacetylase family
uniprot
proteins
pubmed
10545197
uniprot
proteins
pubmed
10644367
uniprot
proteins
pubmed
10888872
uniprot
proteins
pubmed
10904264
uniprot
proteins
pubmed
11331609
uniprot
proteins
pubmed
11533236
uniprot
proteins
pubmed
11739383
uniprot
proteins
pubmed
12140263
uniprot
proteins
pubmed
12176973
uniprot
proteins
pubmed
12402037
uniprot
proteins
pubmed
12493763
uniprot
proteins
pubmed
12670868
uniprot
proteins
pubmed
12724404
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14633989
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15060175
uniprot
proteins
pubmed
15456770
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15701600
uniprot
proteins
pubmed
15927959
uniprot
proteins
pubmed
16428440
uniprot
proteins
pubmed
16820529
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18212045
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18757745
uniprot
proteins
pubmed
19061646
uniprot
proteins
pubmed
19182791
uniprot
proteins
pubmed
19343227
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19433865
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19729656
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20392638
uniprot
proteins
pubmed
20523938
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21549307
uniprot
proteins
pubmed
21573134
uniprot
proteins
pubmed
21914818
uniprot
proteins
pubmed
21965678
uniprot
proteins
pubmed
22926524
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24970816
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25593309
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28497810
uniprot
proteins
pubmed
28977666
uniprot
proteins
pubmed
29192674
uniprot
proteins
pubmed
32051553
uniprot
proteins
pubmed
33283408
uniprot
proteins
pubmed
35044827
uniprot
proteins
pubmed
37137925
uniprot
proteins
pubmed
8917507
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:24970816, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Cytoplasm {ECO:0000269|PubMed:24970816}.
uniprot
proteins