CCNL1
entrez
57018
canonical
uniprot
Q9UK58
canonical
ensembl
ENSG00000163660
resolver
ensp
ENSP00000295926
resolver
ensp
ENSP00000420277
resolver
ensp
ENSP00000541149
resolver
genesymbol
CCNL1
resolver
hgnc
HGNC:20569
resolver
uniprot
B3KMY3
resolver
uniprot
C9JPL0
resolver
uniprot
Q6NVY9
resolver
uniprot
Q6UWS7
resolver
uniprot
Q8NI48
resolver
uniprot
Q96QT0
resolver
uniprot
Q9NZF3
resolver
uniprot_entry
CCNL1_HUMAN
resolver
uniprot_sec
B3KMY3
resolver
uniprot_sec
C9JPL0
resolver
uniprot_sec
Q6NVY9
resolver
uniprot_sec
Q6UWS7
resolver
uniprot_sec
Q8NI48
resolver
uniprot_sec
Q96QT0
resolver
uniprot_sec
Q9NZF3
resolver
amino_acid_sequence
MASGPHSTATAAAAASSAAPSAGGSSSGTTTTTTTTTGGILIGDRLYSEVSLTIDHSLIPEERLSPTPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQVAMATGQVLFHRFFYSKSFVKHSFEIVAMACINLASKIEEAPRRIRDVINVFHHLRQLRGKRTPSPLILDQNYINTKNQVIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQTLVQTAWNYMNDSLRTNVFVRFQPETIACACIYLAARALQIPLPTRPHWFLLFGTTEEEIQEICIETLRLYTRKKPNYELLEKEVEKRKVALQEAKLKAKGLNPDGTPALSTLGGFSPASKPSSPREVKAEEKSPISINVKTVKKEPEDRQQASKSPYNGVRKDSKRSRNSRSASRSRSRTRSRSRSHTPRRHYNNRRSRSGTYSSRSRSRSRSHSESPRRHHNHGSPHLKAKHTRDDLKSSNRHGHKRKKSRSRSQSKSRDHSDAAKKHRHERGHHRDRRERSRSFERSHKSKHHGGSRSGHGRHRR
uniprot
proteins
function
FUNCTION: Regulatory component of the cyclin-L-CDK11 complex that regulates transcription and pre-mRNA splicing (PubMed:11980906, PubMed:18216018, PubMed:38059508). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036). {ECO:0000269|PubMed:11980906, ECO:0000269|PubMed:12414649, ECO:0000269|PubMed:15700036, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:38059508}.
uniprot
proteins
mass_dalton
59634
uniprot
proteins
protein_family
Cyclin L subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11980906
uniprot
proteins
pubmed
12414649
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15700036
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
18216018
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
34696162
uniprot
proteins
pubmed
38059508
uniprot
proteins
sequence_length
526
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:18216018}. Nucleus, nucleoplasm {ECO:0000269|PubMed:18216018}. Note=Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. {ECO:0000250|UniProtKB:Q9R1Q2}.
uniprot
proteins