OGG1
entrez
4968
canonical
uniprot
O15527
canonical
ensembl
ENSG00000114026
resolver
ensp
ENSP00000305527
resolver
ensp
ENSP00000305584
resolver
ensp
ENSP00000306561
resolver
ensp
ENSP00000342851
resolver
ensp
ENSP00000344899
resolver
ensp
ENSP00000345520
resolver
ensp
ENSP00000373337
resolver
ensp
ENSP00000403598
resolver
ensp
ENSP00000516725
resolver
ensp
ENSP00000722346
resolver
ensp
ENSP00000722348
resolver
ensp
ENSP00000787923
resolver
ensp
ENSP00000795202
resolver
ensp
ENSP00000795203
resolver
enst
ENST00000707074
resolver
genesymbol
OGG1
resolver
genesymbol_syn
MMH
resolver
genesymbol_syn
MUTM
resolver
genesymbol_syn
OGH1
resolver
hgnc
HGNC:8125
resolver
uniprot
A0A9L9PXU1
resolver
uniprot
A8K1E3
resolver
uniprot
E5KPM5
resolver
uniprot
E5KPM6
resolver
uniprot
E5KPM7
resolver
uniprot
E5KPM8
resolver
uniprot
E5KPM9
resolver
uniprot
E5KPN0
resolver
uniprot
E5KPN1
resolver
uniprot
O00390
resolver
uniprot
O00670
resolver
uniprot
O00705
resolver
uniprot
O14876
resolver
uniprot
O95488
resolver
uniprot
P78554
resolver
uniprot
Q9BW42
resolver
uniprot
Q9UIK0
resolver
uniprot
Q9UIK1
resolver
uniprot
Q9UIK2
resolver
uniprot
Q9UL34
resolver
uniprot
Q9Y2C0
resolver
uniprot
Q9Y2C1
resolver
uniprot
Q9Y6C3
resolver
uniprot
Q9Y6C4
resolver
uniprot_entry
A0A9L9PXU1_HUMAN
resolver
uniprot_entry
E5KPM5_HUMAN
resolver
uniprot_entry
E5KPM6_HUMAN
resolver
uniprot_entry
E5KPM7_HUMAN
resolver
uniprot_entry
E5KPM8_HUMAN
resolver
uniprot_entry
E5KPM9_HUMAN
resolver
uniprot_entry
E5KPN0_HUMAN
resolver
uniprot_entry
E5KPN1_HUMAN
resolver
uniprot_entry
OGG1_HUMAN
resolver
uniprot_sec
A8K1E3
resolver
uniprot_sec
O00390
resolver
uniprot_sec
O00670
resolver
uniprot_sec
O00705
resolver
uniprot_sec
O14876
resolver
uniprot_sec
O95488
resolver
uniprot_sec
P78554
resolver
uniprot_sec
Q9BW42
resolver
uniprot_sec
Q9UIK0
resolver
uniprot_sec
Q9UIK1
resolver
uniprot_sec
Q9UIK2
resolver
uniprot_sec
Q9UL34
resolver
uniprot_sec
Q9Y2C0
resolver
uniprot_sec
Q9Y2C1
resolver
uniprot_sec
Q9Y6C3
resolver
uniprot_sec
Q9Y6C4
resolver
amino_acid_sequence
MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG
uniprot
proteins
disease_involvement
DISEASE: Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
ec_number
4.2.99.18
uniprot
proteins
function
FUNCTION: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
uniprot
proteins
mass_dalton
38782
uniprot
proteins
mutagenesis
MUTAGEN 249; /note="K->Q: Loss of activity."; /evidence="ECO:0000269|PubMed:9197244"; MUTAGEN 268; /note="D->E,Q: No effect on activity."; /evidence="ECO:0000269|PubMed:12578369"; MUTAGEN 268; /note="D->N: Decreases activity about 65-fold."; /evidence="ECO:0000269|PubMed:12578369
uniprot
proteins
protein_family
Type-1 OGG1 family
uniprot
proteins
pubmed
10233168
uniprot
proteins
pubmed
10449904
uniprot
proteins
pubmed
10497264
uniprot
proteins
pubmed
10706276
uniprot
proteins
pubmed
10775435
uniprot
proteins
pubmed
10908322
uniprot
proteins
pubmed
11902834
uniprot
proteins
pubmed
12509224
uniprot
proteins
pubmed
12578369
uniprot
proteins
pubmed
12592398
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15610848
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17114185
uniprot
proteins
pubmed
17148573
uniprot
proteins
pubmed
9187114
uniprot
proteins
pubmed
9190902
uniprot
proteins
pubmed
9197244
uniprot
proteins
pubmed
9207108
uniprot
proteins
pubmed
9223305
uniprot
proteins
pubmed
9223306
uniprot
proteins
pubmed
9321410
uniprot
proteins
pubmed
9348312
uniprot
proteins
pubmed
9662341
uniprot
proteins
pubmed
9765618
uniprot
proteins
sequence_length
345
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:17148573}. Nucleus speckle {ECO:0000269|PubMed:17148573}. Nucleus matrix {ECO:0000269|PubMed:17148573}. Note=Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.; SUBCELLULAR LOCATION: [Isoform 1A]: Nucleus.; SUBCELLULAR LOCATION: [Isoform 2A]: Mitochondrion.
uniprot
proteins