Cxcl10
entrez
245920
canonical
uniprot
P48973
canonical
ensembl
ENSRNOG00000022256
resolver
ensembl
ENSRNOG00055006321
resolver
ensembl
ENSRNOG00060018593
resolver
ensembl
ENSRNOG00065018120
resolver
ensp
ENSRNOP00000003649
resolver
ensp
ENSRNOP00055007953
resolver
ensp
ENSRNOP00060026012
resolver
ensp
ENSRNOP00065024131
resolver
enst
ENSRNOT00000003075
resolver
enst
ENSRNOT00055010270
resolver
enst
ENSRNOT00060031993
resolver
enst
ENSRNOT00065030352
resolver
genesymbol
Cxcl10
resolver
genesymbol_syn
Inp10
resolver
genesymbol_syn
Mob1
resolver
genesymbol_syn
Scyb10
resolver
uniprot
P70538
resolver
uniprot
Q6GTC7
resolver
uniprot_entry
CXL10_RAT
resolver
uniprot_sec
P70538
resolver
uniprot_sec
Q6GTC7
resolver
amino_acid_sequence
MNPSAAVVLCLVLLSLSGTQGIPLARTVRCTCIDFHEQPLRPRAIGKLEIIPASLSCPHVEIIATMKKNNEKRCLNPESEAIKSLLKAVSQRRSKRAP
uniprot
proteins
function
FUNCTION: Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity) (PubMed:30257241, PubMed:30448292). {ECO:0000250|UniProtKB:P02778, ECO:0000250|UniProtKB:P17515, ECO:0000269|PubMed:30257241, ECO:0000269|PubMed:30448292}.
uniprot
proteins
mass_dalton
10729
uniprot
proteins
protein_family
Intercrine alpha (chemokine CxC) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
30257241
uniprot
proteins
pubmed
30448292
uniprot
proteins
pubmed
7809069
uniprot
proteins
pubmed
8798675
uniprot
proteins
sequence_length
98
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02778}.
uniprot
proteins