Rdh5
entrez
19682
canonical
uniprot
O55240
canonical
ensembl
ENSMUSG00000025350
resolver
ensp
ENSMUSP00000026406
resolver
ensp
ENSMUSP00000168858
resolver
enst
ENSMUST00000026406
resolver
genesymbol
Rdh5
resolver
genesymbol_syn
Rdh4
resolver
genesymbol_syn
cRDH
resolver
genesymbol_syn
rdh
resolver
uniprot
Q8BSF7
resolver
uniprot_entry
Q8BSF7_MOUSE
resolver
uniprot_entry
RDH5_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 9-cis-, 13-cis- and all-trans-retinoic acids, with the most potent inhibitor being 13-cis-retinoic acid. Weakly inhibited by oleic acid. {ECO:0000269|PubMed:10588954}.
uniprot
proteins
amino_acid_sequence
MWLPLLLGALLWAVLWLLRDRQSLPASDAFIFITGCDSGFGRLLALQLDQKGFQVLAGCLTPSGAEDLQQMASSRLHTTLLDITDPQNVQQVAKWVKTRVGETGLFGLVNNAGVAGIIGPTPWLTQDDFQRVLSVNTLGPIGVTLALLPLLQQARGRVVNITSVLGRIAANGGGYCVSKFGLEAFSDSLRRDMAPFGVQVSIVEPGFFRTPVTNLESLESTLKACWARLPPAIQAHYGEAFLDTYLRVQRRIMNLICDPELTKVTSCLEHALTARHPRTRYSPGWDAKLLWLPASYLPARVVDAVLTWILPRPAQSVS
uniprot
proteins
ec_number
1.1.1.209
uniprot
proteins
ec_number
1.1.1.315
uniprot
proteins
ec_number
1.1.1.53
uniprot
proteins
function
FUNCTION: Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:10588954, PubMed:9539749). Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates (By similarity). {ECO:0000250|UniProtKB:Q27979, ECO:0000250|UniProtKB:Q92781, ECO:0000269|PubMed:10588954, ECO:0000269|PubMed:9539749}.
uniprot
proteins
mass_dalton
34826
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000303|PubMed:9539749}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
10588954
uniprot
proteins
pubmed
10739682
uniprot
proteins
pubmed
10825191
uniprot
proteins
pubmed
11279029
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16223484
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9539749
uniprot
proteins
pubmed
9654122
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10739682, ECO:0000269|PubMed:11279029}; Multi-pass membrane protein {ECO:0000255}; Lumenal side {ECO:0000269|PubMed:10739682, ECO:0000269|PubMed:11279029, ECO:0000269|PubMed:16223484}.
uniprot
proteins
transmembrane_region
TRANSMEM 1..23; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins