Q69383
uniprot
Q69383
canonical
amino_acid_sequence
MNPSEMQRKAPPRRRRHRNRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVSAGVPNSSEETATIENGP
uniprot
proteins
function
FUNCTION: Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts. {ECO:0000269|PubMed:10516058, ECO:0000269|PubMed:10557333, ECO:0000269|PubMed:10980608, ECO:0000269|PubMed:11000203, ECO:0000269|PubMed:11105755, ECO:0000269|PubMed:11581404}.
uniprot
proteins
mass_dalton
11828
uniprot
proteins
mutagenesis
MUTAGEN 4..6; /note="SEM->AAA: No loss of function."; /evidence="ECO:0000269|PubMed:11000203"; MUTAGEN 13..15; /note="RRR->AAA: Total loss of function and dominant negative effect."; /evidence="ECO:0000269|PubMed:11000203"; MUTAGEN 13; /note="R->A: Total loss of function and dominant negative effect; when associated with A-14; A-16; A-18 and A-20."; /evidence="ECO:0000269|PubMed:10936083"; MUTAGEN 14; /note="R->A: Total loss of function and dominant negative effect; when associated with A-13; A-16; A-18 and A-20."; /evidence="ECO:0000269|PubMed:10936083"; MUTAGEN 16; /note="R->A: Total loss of function and dominant negative effect; when associated with A-13; A-14; A-18 and A-20."; /evidence="ECO:0000269|PubMed:10936083"; MUTAGEN 18; /note="R->A: Total loss of function and dominant negative effect; when associated with A-13; A-14; A-16 and A-20."; /evidence="ECO:0000269|PubMed:10936083"; MUTAGEN 19..20; /note="NR->AA: No loss of function."; /evidence="ECO:0000269|PubMed:11000203"; MUTAGEN 20; /note="R->A: Total loss of function and dominant negative effect; when associated with A-13; A-14; A-16 and A-18."; /evidence="ECO:0000269|PubMed:10936083"; MUTAGEN 30..32; /note="MVT->AAA: Total loss of function and dominant negative effect."; /evidence="ECO:0000269|PubMed:11000203"; MUTAGEN 37..39; /note="MKL->AAA: Total loss of function and dominant negative effect."; /evidence="ECO:0000269|PubMed:11000203"; MUTAGEN 42..44; /note="TKK->AAA: Total loss of function and dominant negative effect."; /evidence="ECO:0000269|PubMed:11000203"; MUTAGEN 48..50; /note="PTW->AAA: Total loss of function and dominant negative effect."; /evidence="ECO:0000269|PubMed:11000203"; MUTAGEN 53..55; /note="LKK->AAA: Total loss of function and dominant negative effect."; /evidence="ECO:0000269|PubMed:11000203"; MUTAGEN 53; /note="L->A: Exclusive nuclear localization; when associated with A-56 and A-59."; /evidence="ECO:0000269|PubMed:10683442"; MUTAGEN 56; /note="L->A: Exclusive nuclear localization; when associated with A-53 and A-59."; /evidence="ECO:0000269|PubMed:10683442"; MUTAGEN 59..61; /note="LAT->AAA: Partial loss of function."; /evidence="ECO:0000269|PubMed:11000203"; MUTAGEN 59; /note="L->A: Exclusive nuclear localization; when associated with A-53 and A-56."; /evidence="ECO:0000269|PubMed:10683442"; MUTAGEN 66..68; /note="NTK->AAA: Total loss of function and dominant negative effect."; /evidence="ECO:0000269|PubMed:11000203"; MUTAGEN 76..78; /note="MLL->AAA: Total loss of function and dominant negative effect."; /evidence="ECO:0000269|PubMed:11000203"; MUTAGEN 82..84; /note="MIV->AAA: Total loss of function and dominant negative effect."; /evidence="ECO:0000269|PubMed:11000203"; MUTAGEN 86..88; /note="MVS->AAA: Partial loss of function."; /evidence="ECO:0000269|PubMed:11000203"; MUTAGEN 93..95; /note="NSS->AAA: No loss of function."; /evidence="ECO:0000269|PubMed:11000203
uniprot
proteins
pubmed
10080172
uniprot
proteins
pubmed
10469592
uniprot
proteins
pubmed
10516026
uniprot
proteins
pubmed
10516058
uniprot
proteins
pubmed
10557333
uniprot
proteins
pubmed
10683442
uniprot
proteins
pubmed
10936083
uniprot
proteins
pubmed
10980608
uniprot
proteins
pubmed
11000203
uniprot
proteins
pubmed
11105755
uniprot
proteins
pubmed
11287007
uniprot
proteins
pubmed
11401447
uniprot
proteins
pubmed
11581404
uniprot
proteins
pubmed
12083821
uniprot
proteins
pubmed
15063128
uniprot
proteins
pubmed
7983704
uniprot
proteins
pubmed
9060628
uniprot
proteins
sequence_length
105
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus.
uniprot
proteins