IL24
entrez
11009
canonical
uniprot
Q13007
canonical
ensembl
ENSG00000162892
resolver
ensp
ENSP00000294984
resolver
ensp
ENSP00000356060
resolver
ensp
ENSP00000375795
resolver
ensp
ENSP00000484900
resolver
genesymbol
IL24
resolver
genesymbol_syn
MDA7
resolver
genesymbol_syn
ST16
resolver
hgnc
HGNC:11346
resolver
uniprot
Q2YHE5
resolver
uniprot
Q53XZ7
resolver
uniprot
Q5YLN8
resolver
uniprot
Q96DB0
resolver
uniprot
Q96KG4
resolver
uniprot_entry
IL24_HUMAN
resolver
uniprot_sec
Q2YHE5
resolver
uniprot_sec
Q53XZ7
resolver
uniprot_sec
Q5YLN8
resolver
uniprot_sec
Q96DB0
resolver
uniprot_sec
Q96KG4
resolver
amino_acid_sequence
MNFQQRLQSLWTLARPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL
uniprot
proteins
function
FUNCTION: Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity). {ECO:0000250|UniProtKB:Q925S4, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:25168428, ECO:0000269|PubMed:27687232, ECO:0000269|PubMed:30111632}.
uniprot
proteins
mass_dalton
23825
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:11706020}.; PTM: Ubiquitination at Lys-122 promotes proteasomal degradation. {ECO:0000269|PubMed:23078624}.
uniprot
proteins
protein_family
IL-10 family
uniprot
proteins
pubmed
11704829
uniprot
proteins
pubmed
11706020
uniprot
proteins
pubmed
15304100
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16313301
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
23078624
uniprot
proteins
pubmed
25168428
uniprot
proteins
pubmed
27687232
uniprot
proteins
pubmed
30111632
uniprot
proteins
pubmed
8545104
uniprot
proteins
pubmed
9826712
uniprot
proteins
sequence_length
206
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11706020}.
uniprot
proteins