Trip13
entrez
292206
canonical
uniprot
Q5XHZ9
canonical
ensembl
ENSRNOG00000015810
resolver
ensembl
ENSRNOG00055003289
resolver
ensembl
ENSRNOG00060025164
resolver
ensembl
ENSRNOG00065018364
resolver
ensp
ENSRNOP00000021532
resolver
ensp
ENSRNOP00055003794
resolver
ensp
ENSRNOP00060036173
resolver
ensp
ENSRNOP00065024526
resolver
enst
ENSRNOT00000021532
resolver
enst
ENSRNOT00055005102
resolver
enst
ENSRNOT00060043626
resolver
enst
ENSRNOT00065030813
resolver
genesymbol
Trip13
resolver
genesymbol_syn
Pch2
resolver
uniprot_entry
PCH2_RAT
resolver
amino_acid_sequence
MDDAVGDLKQALPCVAESPAVHVEVLQRSGSTAKKEDIKQSVYRLLKRHNIVFGDYVWTEFDEPFLTRNVQSVSIVDTELKAKDPQPIDLSACTIALHIFQLNEEGPSSENLDEETENIIAASHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVDSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKEALVFVLIDEVESLTAARNACRAGAEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLSEISRKSEGLSGRVLRKLPFLAHALYIQAPSVTIEGFLQALSLAVDKQFEEKKKLSAHV
uniprot
proteins
function
FUNCTION: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Plays a role in mitotic spindle assembly checkpoint (SAC) activation (By similarity). {ECO:0000250|UniProtKB:Q15645, ECO:0000250|UniProtKB:Q3UA06}.
uniprot
proteins
mass_dalton
48434
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
protein_family
PCH2 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
432
uniprot
proteins