Togaram1
entrez
328108
canonical
uniprot
Q6A070
canonical
ensembl
ENSMUSG00000035614
resolver
ensp
ENSMUSP00000070382
resolver
ensp
ENSMUSP00000152616
resolver
ensp
ENSMUSP00000279866
resolver
ensp
ENSMUSP00000279869
resolver
ensp
ENSMUSP00000279875
resolver
enst
ENSMUST00000223166
resolver
genesymbol
Togaram1
resolver
genesymbol_syn
Fam179b
resolver
genesymbol_syn
Kiaa0423
resolver
uniprot
A0A1Y7VLS3
resolver
uniprot
F8WJB2
resolver
uniprot_entry
A0A1Y7VLS3_MOUSE
resolver
uniprot_entry
TGRM1_MOUSE
resolver
uniprot_sec
F8WJB2
resolver
amino_acid_sequence
MAAAPSELLPLPPPATPGSYRLLSRCRPYAPGTDGRRSGGTMRGEKNYYCRGAAGDHGSCPATPSPLASTLLLPAEAVSTSWSGPGSGLSGGDEEETRLLQLLRTAPDPSEAFQALQAALPRRGGRLGFPRRKEALYRALGRVLVEGGSEEKRLCLQLLSDVLRGQGEAGQLEEAFSLALLPQLVVSLREDNPALRKDALQILHICLRRSSGQVLRTLIQGLESPDARLRASTALLLPILFTPEDLLQGLDLTEVIISLARKLGDQEMEEESETAFSSLQQIGERLGQERFHSYISRLPSALRRHYNRRLESQYGSQVPYYLELEASGFSEDAAPCVVNLSSSNLKFEIIPQELHARLLDQEDYKNRTQAVEELKQLLGKFNPSSTPHASLVGFISLLYNLLDDSNFKVVHGTLQVLHLLVIRLGEQVQQFLGPVIAASVKVLADNKLVIKQEYMKIFLKLMKEVGPQRVLSLLLENLKHKHSRVREEVVNICICSLLTYPSEDFDLPKLSFDLAPALVDSKRRVRQAALEAFAVLASSMGSGKTNVLFKAVDTVELQDNGDGVMNAVQARLARKTLPRLTEQGFVEYAILMPSSAQGRSSHLAHGADTDWLMSGNRTQSAHCYCGDHTRDSMQLYGSYSPTICTRRVLSAGKGKNKLPWENEQPGVMGENQTSNSKDIKDTEQFSAHDLIPSPKLKPSQGMPASDDLCFSKKRSSRNLFQSSRDFNSESVPTCGAGNTADLQTNLPGKCGQLGLSQIGCRTGSVGSDLQFLGTANGHQDKVYASIDFGSKTQQTFGSQSERTSSYSGSNASPGSFILPSYPLASPRTSPKHTSPLSVAPKKSQDNSISFSNSWPLKSFEGLSKPSPQKKLANQKSSDPTGENFQEKTTAVQLTPALVRSPSSRRGLNGTKPVPPIPRGINLLPDKADLSTMGHMKKQPDDIWKSEKDNLTIDLSELNFRDKDLDQEEMHSSLRSLRNSAAKKRAKLSGSSSTSDVDSPDSAMKLELTIDSPSRASSPNISSYSESGVYSQESLTSSLSTTPQGKRIMSDIFPTFGSKPCSTRLSSAKKTSHAAEQSPSAGFTRSSNLQQISSFDFTSTNTLSEDSVVIVGKGVFGNPNSAPTTCSQPVISSVESEDTFPVKPSIEPPSGVYGRAVQHNAPLYPEVENDKDTKVSIAKSTYEKMRQKRKEEKELLDAKDCERKETNPWERIKHLGSEKMTSENEPSSGVIPQYKERMSSVTHSPEIMDSLELRPFSKPDIALTEALRLLADEDWEKKMEGLNFVRCLAAFHSDLLNTKLHETTFAVVQEVKNLRSGVSRAAVVCLGDLFTYLKKSMDQELDSAVRALLHKAGESNTFIREDVDKALKAMVNNVTPARAVTSLINGGQSHLHIAVRRCTAQHLADVVECMDPERISSGTKDMADRLLPAAAKFAQDSSQETRYYGRKMLFLMMGHPNFEKLLEKYIPSKDLPYIKESVKNLRLKGLGEIPLDTASAKGRRSHPGSVGNTRSSSVSRDAFSSSEREVTEVREVPRKSAPRNSLESAEYIKVITGLLNAKDFRDRINGIKQLLSDTENNQELVVGNIVKIFDAFKSRLHDSNSKVNLVALETMHKMIPLLRDNLSPIINMLIPAIVDNNLNSKNPGIYAAATNVVHALSQHVDNYLLLQPFCTKAQFLNGKAKQDMTEKLADIVTELYQRKPHATEQKVLVVLWHLLGNMTHSGSLPGAGGNIRTATAKLSKALFTQMGQNLLNQAASQPPHIKKSLEELLDVTVLSEL
uniprot
proteins
function
FUNCTION: Involved in ciliogenesis. It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (PubMed:26378256, PubMed:32747439). {ECO:0000250|UniProtKB:Q17423, ECO:0000269|PubMed:26378256, ECO:0000269|PubMed:32747439}.
uniprot
proteins
mass_dalton
194910
uniprot
proteins
mutagenesis
MUTAGEN 364; /note="Y->E: Expected to disrupt microtubule binding. Abolishes the ability to promote microtubule polymerization."; /evidence="ECO:0000269|PubMed:26378256"; MUTAGEN 367; /note="R->W: Resulty in increased tubulin polymerization in vitro."; /evidence="ECO:0000269|PubMed:32747439"; MUTAGEN 1274; /note="W->E: Abolishes association with microtubules."; /evidence="ECO:0000269|PubMed:26378256"; MUTAGEN 1559; /note="F->E: Abolishes association with microtubules and the ability to promote microtubule polymerization."; /evidence="ECO:0000269|PubMed:26378256
uniprot
proteins
protein_family
Crescerin family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26378256
uniprot
proteins
pubmed
32747439
uniprot
proteins
sequence_length
1776
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:26378256}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:26378256}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9Y4F4}. Note=Detected along the length of primary cilia and at the basal body. Colocalization with the cytoplasmic microtubule cytoskeleton upon heterologous expression is most likely an artifact. {ECO:0000269|PubMed:26378256}.
uniprot
proteins