Lypla2
entrez
83510
canonical
uniprot
Q9QYL8
canonical
ensembl
ENSRNOG00000010067
resolver
ensembl
ENSRNOG00055026757
resolver
ensembl
ENSRNOG00060031614
resolver
ensembl
ENSRNOG00065025631
resolver
ensp
ENSRNOP00000014415
resolver
ensp
ENSRNOP00000086675
resolver
ensp
ENSRNOP00055037972
resolver
ensp
ENSRNOP00060045313
resolver
ensp
ENSRNOP00065036287
resolver
enst
ENSRNOT00000014415
resolver
enst
ENSRNOT00000103673
resolver
enst
ENSRNOT00055046252
resolver
enst
ENSRNOT00060054799
resolver
enst
ENSRNOT00065044206
resolver
genesymbol
Lypla2
resolver
uniprot
A0A8I6AB78
resolver
uniprot_entry
A0A8I6AB78_RAT
resolver
uniprot_entry
LYPA2_RAT
resolver
amino_acid_sequence
MCGNNMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRNFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRTVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV
uniprot
proteins
ec_number
3.1.2.-
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
function
FUNCTION: Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GSDMD, GAP43, ZDHHC6 or HRAS (By similarity). Deacylates GAP43 (By similarity). Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity (By similarity). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (By similarity). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (By similarity). {ECO:0000250|UniProtKB:O95372, ECO:0000250|UniProtKB:Q9WTL7}.
uniprot
proteins
mass_dalton
24807
uniprot
proteins
protein_family
AB hydrolase 2 family
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
231
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O95372}.
uniprot
proteins