Ddx6
entrez
13209
canonical
uniprot
P54823
canonical
ensembl
ENSMUSG00000032097
resolver
ensp
ENSMUSP00000128421
resolver
ensp
ENSMUSP00000149620
resolver
ensp
ENSMUSP00000265552
resolver
ensp
ENSMUSP00000265553
resolver
ensp
ENSMUSP00000265554
resolver
ensp
ENSMUSP00000265560
resolver
ensp
ENSMUSP00000265561
resolver
enst
ENSMUST00000170489
resolver
enst
ENSMUST00000217034
resolver
genesymbol
Ddx6
resolver
genesymbol_syn
Hlr2
resolver
genesymbol_syn
Rck
resolver
uniprot
O54979
resolver
uniprot
Q3UFI3
resolver
uniprot
Q8BW68
resolver
uniprot_entry
DDX6_MOUSE
resolver
uniprot_sec
O54979
resolver
uniprot_sec
Q3UFI3
resolver
uniprot_sec
Q8BW68
resolver
amino_acid_sequence
MSTARTENPVIMGLSSQNGQLRGPVKASAGPGGGGTQPQPQLNQLKNTSTINNGTPQQAQSMAATIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPAEDEKP
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (By similarity). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (By similarity). In the process of mRNA degradation, plays a role in mRNA decapping (By similarity). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). {ECO:0000250|UniProtKB:P26196, ECO:0000269|PubMed:26098573}.
uniprot
proteins
mass_dalton
54192
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000250|UniProtKB:P26196}.
uniprot
proteins
protein_family
DDX6/DHH1 subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20639877
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26098573
uniprot
proteins
pubmed
37083226
uniprot
proteins
pubmed
8543178
uniprot
proteins
pubmed
9883581
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000250|UniProtKB:P26196}. Cytoplasm {ECO:0000250|UniProtKB:P26196}. Nucleus {ECO:0000250|UniProtKB:P26196}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:37083226}. Note=Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism. Upon cellular stress, relocalizes to stress granules. {ECO:0000250|UniProtKB:P26196}.
uniprot
proteins