Cyp21
entrez
13079
canonical
uniprot
P03940
canonical
ensembl
ENSMUSG00000024365
resolver
ensp
ENSMUSP00000025223
resolver
enst
ENSMUST00000025223
resolver
genesymbol
Cyp21
resolver
genesymbol
Cyp21a1
resolver
genesymbol_syn
Cyp21a-1
resolver
genesymbol_syn
Cyp21a1
resolver
uniprot
A0A0R4J048
resolver
uniprot
A0JP50
resolver
uniprot
O88304
resolver
uniprot
Q3UJ92
resolver
uniprot
Q64510
resolver
uniprot
Q9QX14
resolver
uniprot_entry
A0A0R4J048_MOUSE
resolver
uniprot_entry
CP21A_MOUSE
resolver
uniprot_entry
Q3UJ92_MOUSE
resolver
uniprot_sec
A0JP50
resolver
uniprot_sec
O88304
resolver
uniprot_sec
Q64510
resolver
uniprot_sec
Q9QX14
resolver
amino_acid_sequence
MLLPGLLLLLLLLAGTRWLWGQWKLRKLHLPPLAPGFLHFLQPNLPIYLLGLTQKLGPIYRIRLGMQDVVVLNSNRTIEEALIQKWVDFAGRPHMLNGKMDLDLSLGDYSLMWKAHKKLSRSALMLGMRDSMEPLIEQLTQEFCERMRAQAGTPVAIHKEFSFLTCSIISCLTFGDKDSTLVQTLHDCVQDLLQAWNHWSIQILTIIPLLRFLPNPGLQKLKQIQESRDHIVKQQLKQHKDSLVAGQWKDMIDYMLQGVEKQRDGKDEERLHEGHVHMSVVDLFIGGTETTATTLSWAVAFLLHHPEIQKRLQEELDLKLGPGSQLLYRNRMQLPLLMATIAEVLRLRPVVPLALPHRATRASSISGYDIPKDMVIIPNIQGANLDEMVWELPSKFWPDRFLEPGKNPRTPSFGCGARVCLGEPLARLELFVVLARLLQAFTLLPPPDGTLPSLQPQPYAGINLPIPPFQVRLQPRNLAPQDQGERP
uniprot
proteins
ec_number
1.14.14.16
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). {ECO:0000250|UniProtKB:P00191, ECO:0000250|UniProtKB:P08686}.
uniprot
proteins
mass_dalton
55328
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1918990
uniprot
proteins
pubmed
3491986
uniprot
proteins
pubmed
3874401
uniprot
proteins
sequence_length
487
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P08686}; Peripheral membrane protein {ECO:0000250|UniProtKB:P08686}. Microsome membrane {ECO:0000250|UniProtKB:P08686}; Peripheral membrane protein {ECO:0000250|UniProtKB:P08686}.
uniprot
proteins