Ptger1
entrez
25637
canonical
uniprot
P70597
canonical
genesymbol
Ptger1
resolver
uniprot
P97537
resolver
uniprot_entry
PE2R1_RAT
resolver
uniprot_sec
P97537
resolver
amino_acid_sequence
MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL
uniprot
proteins
function
FUNCTION: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function (By similarity). Implicated the smooth muscle contractile response to PGE2 in various tissues. Isoform 1 and isoform 2 have identical ligand binding properties, but isoform 2 lacks coupling to calcium mobilization and may therefore attenuate the action of PGE2 on tissues. {ECO:0000250}.
uniprot
proteins
mass_dalton
43048
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000305}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
8940129
uniprot
proteins
pubmed
9537820
uniprot
proteins
sequence_length
405
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 40..62; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 81..99; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 114..135; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 158..179; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 203..228; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 302..323; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 338..357; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins