Scnn1g
entrez
24768
canonical
uniprot
P37091
canonical
ensembl
ENSRNOG00000017842
resolver
ensembl
ENSRNOG00055008625
resolver
ensembl
ENSRNOG00060028078
resolver
ensembl
ENSRNOG00065031487
resolver
ensp
ENSRNOP00000024057
resolver
ensp
ENSRNOP00055011623
resolver
ensp
ENSRNOP00060040675
resolver
ensp
ENSRNOP00065044650
resolver
enst
ENSRNOT00000024057
resolver
enst
ENSRNOT00055014552
resolver
enst
ENSRNOT00060048763
resolver
enst
ENSRNOT00065054273
resolver
genesymbol
Scnn1g
resolver
genesymbol_syn
RCNaCh2
resolver
uniprot
G3V8A6
resolver
uniprot_entry
G3V8A6_RAT
resolver
uniprot_entry
SCNNG_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Originally identified and characterized by its inhibition by the diuretic drug amiloride. {ECO:0000269|PubMed:8107805, ECO:0000269|PubMed:8188647}.
uniprot
proteins
amino_acid_sequence
MAPGEKIKAKIKKNLPVRGPQAPTIKDLMHWYCMNTNTHGCRRIVVSRGRLRRLLWIAFTLTAVALIIWQCALLVFSFYTVSVSIKVHFQKLDFPAVTICNINPYKYSAVSDLLTDLDSETKQALLSLYGVKESRKRREAGSMPSTLEGTPPRFFKLIPLLVFNENEKGKARDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGMSCDARNFTLFHHPMYGNCYTFNNKENATILSTSMGGSEYGLQVILYINEDEYNPFLVSSTGAKVLIHQQNEYPFIEDVGMEIETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLYQAFVREELGCQSVCKQSCSFKEWTLTTSLAQWPSEASEKWLLNVLTWDQSQQINKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWHKAKDWWARRQTPPSTETPSSRQGQDNPALDTDDDLPTFTSAMRLPPAPGSTVPGTPPPRYNTLRLDRAFSSQLTDTQLTNEL
uniprot
proteins
function
FUNCTION: This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:8107805, PubMed:8188647, PubMed:9118951). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:8107805, PubMed:8188647, PubMed:9118951). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance (By similarity). {ECO:0000250|UniProtKB:P51170, ECO:0000269|PubMed:8107805, ECO:0000269|PubMed:8188647, ECO:0000269|PubMed:9118951}.
uniprot
proteins
mass_dalton
74066
uniprot
proteins
mutagenesis
MUTAGEN 6; /note="K->R: Loss of ubiquitination. Increased expression of functional channels at the plasma membrane; when associated with R-13."; /evidence="ECO:0000269|PubMed:9351815"; MUTAGEN 13; /note="K->R: Loss of ubiquitination. Increased expression of functional channels at the plasma membrane; when associated with R-6."; /evidence="ECO:0000269|PubMed:9351815"; MUTAGEN 40; /note="G->S: Decreased sodium ion transmembrane transport. Decreased channel open probability."; /evidence="ECO:0000269|PubMed:9118951
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. {ECO:0000269|PubMed:9501257}.; PTM: Ubiquitinated. Can be ubiquitinated at multiple sites and undergo monoubiquitination and polyubiquitination. Ubiquitination by NEDD4 or NEDD4L inhibits the ENaC channel through endocytosis, intracellular retention and degradation of its individual subunits. {ECO:0000269|PubMed:11323714, ECO:0000269|PubMed:12424229, ECO:0000269|PubMed:12654927, ECO:0000269|PubMed:8665844, ECO:0000269|PubMed:9351815}.; PTM: ENaC is activated through the proteolytic maturation of its subunits. Furin cleaves the SCNN1G subunit first, followed by cleavage by prostasin (PRSS8), which results in a stepwise increase in the open probability of the channel due to the release of an inhibitory tract. BPIFA1, which is recruited by the SCNN1B subunit, prevents the proteolytic activation of ENaC. {ECO:0000250|UniProtKB:P51170}.; PTM: N-glycosylated. N-linked glycans are processed to complex type during ENaC complex assembly and transport to the plasma membrane. {ECO:0000250|UniProtKB:Q9WU39}.
uniprot
proteins
protein_family
Amiloride-sensitive sodium channel (TC 1.A.6) family
uniprot
proteins
protein_family
SCNN1G subfamily
uniprot
proteins
pubmed
11323714
uniprot
proteins
pubmed
12424229
uniprot
proteins
pubmed
12654927
uniprot
proteins
pubmed
8107805
uniprot
proteins
pubmed
8188647
uniprot
proteins
pubmed
8665844
uniprot
proteins
pubmed
9039092
uniprot
proteins
pubmed
9118951
uniprot
proteins
pubmed
9351815
uniprot
proteins
pubmed
9501257
uniprot
proteins
sequence_length
650
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:8188647, ECO:0000269|PubMed:9118951, ECO:0000269|PubMed:9351815}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51170}.
uniprot
proteins
transmembrane_region
TRANSMEM 56..76; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 543..563; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins