Fut9
entrez
14348
canonical
uniprot
O88819
canonical
ensembl
ENSMUSG00000055373
resolver
ensp
ENSMUSP00000081826
resolver
ensp
ENSMUSP00000103834
resolver
enst
ENSMUST00000084770
resolver
enst
ENSMUST00000108199
resolver
genesymbol
Fut9
resolver
uniprot
Q14AE3
resolver
uniprot
Q3TQ63
resolver
uniprot_entry
FUT9_MOUSE
resolver
uniprot_entry
Q14AE3_MOUSE
resolver
uniprot_sec
Q3TQ63
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Mn2+. {ECO:0000250|UniProtKB:Q9Y231}.
uniprot
proteins
amino_acid_sequence
MTSTSKGILRPFLIVCIILGCFMACLLIYIKPTNSWVFSPMESASSVLKMKNFFSTKTDYFNETTILVWVWPFGQTFDLTSCQAMFNIQGCHLTTDRSLYNKSHAVLIHHRDISWDLTNLPQQARPPFQKWIWMNLESPTHTPQKSGIEHLFNLTLTYRRDSDIQVPYGFLTVSTNPFVFEVPSKEKLVCWVVSNWNPEHARVKYYNELSKSIEIHTYGQAFGEYVNDKNLIPTISTCKFYLSFENSIHKDYITEKLYNAFLAGSVPVVLGPSRENYENYIPADSFIHVEDFNSPSELAKYLKEVDKNNKLYLSYFNWRKDFTVNLPRFWESHACLACDHVKRHQEYKSVGNLEKWFWN
uniprot
proteins
ec_number
2.4.1.152
uniprot
proteins
function
FUNCTION: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc-) glycan attached to glycolipids and N- or O-linked glycoproteins. Fucosylates distal type 2 LacNAc and its fucosylated (H-type 2 LacNAc) and sialylated (sialyl-type 2 LacNAc) derivatives to form Lewis x (Lex) (CD15) and Lewis y (Ley) antigenic epitopes involved in cell adhesion and differentiation (By similarity) (PubMed:12626397, PubMed:15121843, PubMed:16973732, PubMed:22645129, PubMed:9756916). Generates Lex epitopes in the brain, presumably playing a role in the maintenance of neuronal stemness and neurite outgrowth in progenitor neural cells (By similarity) (PubMed:16973732, PubMed:22645129). Fucosylates the internal type 2 LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (By similarity). Can also modify milk oligosaccharides in particular type 2 tetrasaccharide LNnT (By similarity) (PubMed:9756916). {ECO:0000250|UniProtKB:Q9Y231, ECO:0000269|PubMed:12626397, ECO:0000269|PubMed:15121843, ECO:0000269|PubMed:16973732, ECO:0000269|PubMed:22645129, ECO:0000269|PubMed:9756916}.
uniprot
proteins
mass_dalton
42041
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:22645129}.; PATHWAY: Glycolipid biosynthesis. {ECO:0000269|PubMed:12626397, ECO:0000269|PubMed:16973732}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated with complex-type N-glycans. {ECO:0000250|UniProtKB:Q9Y231}.
uniprot
proteins
protein_family
Glycosyltransferase 10 family
uniprot
proteins
pubmed
12626397
uniprot
proteins
pubmed
15121843
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16973732
uniprot
proteins
pubmed
22645129
uniprot
proteins
pubmed
9756916
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9Y231}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q6P4F1}. Golgi apparatus membrane {ECO:0000269|PubMed:12626397}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins