Rab3gap2
entrez
98732
canonical
uniprot
Q8BMG7
canonical
ensembl
ENSMUSG00000039318
resolver
ensp
ENSMUSP00000066325
resolver
ensp
ENSMUSP00000141608
resolver
enst
ENSMUST00000069652
resolver
enst
ENSMUST00000194740
resolver
genesymbol
Rab3gap2
resolver
genesymbol_syn
Kiaa0839
resolver
uniprot
A0A0A6YWM5
resolver
uniprot
E9QKE4
resolver
uniprot
Q3UEY3
resolver
uniprot
Q6PEU0
resolver
uniprot
Q80TQ6
resolver
uniprot
Q8BX72
resolver
uniprot
Q8BYZ6
resolver
uniprot_entry
A0A0A6YWM5_MOUSE
resolver
uniprot_entry
E9QKE4_MOUSE
resolver
uniprot_entry
Q3UEY3_MOUSE
resolver
uniprot_entry
Q8BYZ6_MOUSE
resolver
uniprot_entry
RBGPR_MOUSE
resolver
uniprot_sec
Q6PEU0
resolver
uniprot_sec
Q80TQ6
resolver
uniprot_sec
Q8BX72
resolver
amino_acid_sequence
MACSIVQFCSFQDLQSARDFLFPHLREETPGALKRDPSKTSSWEDDSWGAWEETEPREPEEEGNTSKTQKNSWLQECVLSLSPTSDLMVIAREQKAAFLVRKWKHGDKGKEEMQFAVGWSGSVSAEEGEYVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTEGVLLLAQLLNEDKVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGLQDIDTIIDHASVGIMTLSPFDQMKTASNIGGFNAAIKNSPPAMSQYITVGSSPFTGFFYALEGSTQPLLSHVALAVASKLTSALFSAASGWLGWKSKHEEDTVQKQKPKMEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQVGWIQIVEDLHERVPEKGGFSPFGNTQGPSRVAQFLVIYAPRRGILEVWNTQQGPRVGAFNVGKHCRLLYPGYKIMGLNNVTSQSWQPQTYQICLVDPVSASVKAVNVPFHLALSDKKSERAKDLHLVKKLSALLRAKSPRPDSFETEIKELILDIKYPATKKQALESILASDRLSFSCLRNVTQTLMDTLKNQELESVDEGLLQFCASKLKLLHLYESVSQLNTLDFHSDTPFSDNDLAVLLRLDDKELLKLRALLEKYKQENTKATVRFSEDADRVLPVKTFLEYLEYEKDALSIRKIGEEECVALGSFFFWKCLHGKSSTEEMCHSLESAGLSPQQLLSLLLSVWLSKEKDILDKPQSVCCLHTMLSLLSKMKVAIDETWDSQSVSPWWQQMRMACIQSENSGAALLSAHVGHSVAAQMSSGATDKKFSQMELDADAEALTDSWEALSLDTEYWKLLLRQLEDCLILQTLLHSKLSPPAAKAPSLQSEPLPRLSVKKLLEGGKGGIADSVAKWIFKQDLSPELLKCANKERDVENPDEPREDLLHLAYEQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFLVRSIEHLKQILNPHVQNGIALMMWNTFLVKRFSAATYLMDKVGKSPKDRLCRRDVGMSDTALTSFLGSCLELLQTSLEADISRDEVQVPVLDTEDAWLSVEGPISIVELALEQKPIHYPLVEHHSVLCSILYASMRFSLKSVKPLALFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQAQHSKDKDPSAEAANTHWKDLNWPGLAVDLAHHLQVSDDVIRRHYVGELYSHGADLLGEEAIFQVQDKEVLASQLLVLTGQRLAHALFHTQTKEGMELLARLPPTLCTWLKAMNPQDLQNTGVPIAATAKLVHKVMELLPEKHGQYSLALHLIDAVEAMATL
uniprot
proteins
function
FUNCTION: Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which accelerates the otherwise slow GTP hydrolysis catalyzed by Rab proteins. The complex has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and has guanine nucleotide exchange factor (GEF) activity towards RAB18. The Rab3GAP complex acts as a GEF for RAB18 by promoting GDP release from RAB18 and the conversion of inactive RAB18-GDP to the active form RAB18-GTP. Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated. Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (By similarity). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as cell proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q15042, ECO:0000250|UniProtKB:Q9H2M9}.
uniprot
proteins
mass_dalton
152535
uniprot
proteins
protein_family
Rab3-GAP regulatory subunit family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5U1Z0}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9H2M9}. Note=In neurons, it is enriched in the synaptic soluble fraction. {ECO:0000250|UniProtKB:Q5U1Z0}.
uniprot
proteins