Timm22
entrez
56322
canonical
uniprot
Q9CQ85
canonical
ensembl
ENSMUSG00000020843
resolver
ensp
ENSMUSP00000021203
resolver
ensp
ENSMUSP00000113238
resolver
enst
ENSMUST00000021203
resolver
enst
ENSMUST00000120699
resolver
genesymbol
Timm22
resolver
genesymbol_syn
Tim22
resolver
uniprot
B0QZS8
resolver
uniprot
Q5SSL1
resolver
uniprot
Q5SSL2
resolver
uniprot
Q8QZU2
resolver
uniprot
Q9JKW2
resolver
uniprot_entry
B0QZS8_MOUSE
resolver
uniprot_entry
TIM22_MOUSE
resolver
uniprot_sec
Q5SSL1
resolver
uniprot_sec
Q5SSL2
resolver
uniprot_sec
Q8QZU2
resolver
uniprot_sec
Q9JKW2
resolver
amino_acid_sequence
MAATAPKAGGSAPEAAGSAEAPLQYSLLLQYLVGDKRQPRLLEPGSLGGIPSPAKSEEQKMIERAMESCAFKAVLACVGGFVLGGAFGIFTAGIDTNVGFDPKDPYRTPTAKEVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAGVKAGAIGCGGFAAFSAAIDYYLR
uniprot
proteins
function
FUNCTION: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). {ECO:0000250|UniProtKB:Q12328}.
uniprot
proteins
mass_dalton
20114
uniprot
proteins
post_translational_modification
PTM: Disulfide bonds promote efficient assembly of the TIM22 complex. {ECO:0000250|UniProtKB:Q9Y584}.
uniprot
proteins
protein_family
Tim17/Tim22/Tim23 family
uniprot
proteins
pubmed
10611480
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
194
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9Y584}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 74..94; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 123..143; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins