Pemt
entrez
25511
canonical
uniprot
Q08388
canonical
ensembl
ENSRNOG00000054423
resolver
ensembl
ENSRNOG00055027004
resolver
ensembl
ENSRNOG00060028516
resolver
ensembl
ENSRNOG00065007931
resolver
ensp
ENSRNOP00000074801
resolver
ensp
ENSRNOP00000084752
resolver
ensp
ENSRNOP00000100443
resolver
ensp
ENSRNOP00055038280
resolver
ensp
ENSRNOP00060041355
resolver
ensp
ENSRNOP00065009192
resolver
enst
ENSRNOT00000083698
resolver
enst
ENSRNOT00000112526
resolver
enst
ENSRNOT00000163705
resolver
enst
ENSRNOT00055046642
resolver
enst
ENSRNOT00060049591
resolver
enst
ENSRNOT00065012494
resolver
genesymbol
Pemt
resolver
genesymbol_syn
PEMT
resolver
genesymbol_syn
Pempt
resolver
uniprot
A0A8I6GAY9
resolver
uniprot
A0A8L2RBC3
resolver
uniprot
Q5BK89
resolver
uniprot_entry
A0A8I6GAY9_RAT
resolver
uniprot_entry
A0A8L2RBC3_RAT
resolver
uniprot_entry
PEMT_RAT
resolver
uniprot_sec
Q5BK89
resolver
amino_acid_sequence
MSWLLGYVDPTEPSFVAAVLTIVFNPLFWNVVARWEQRTRKLSRAFGSPYLACYSLGSIILLLNILRSHCFTQAMMSQPKMEGLDSHTIYFLGLALLGWGLVFVLSSFYALGFTGTFLGDYFGILKESRVTTFPFSVLDNPMYWGSTANYLGWALMHASPTGLLLTVLVALVYVVALLFEEPFTAEIYRRKATRLHKRS
uniprot
proteins
ec_number
2.1.1.17
uniprot
proteins
ec_number
2.1.1.71
uniprot
proteins
function
FUNCTION: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure (Probable) (PubMed:8344945). Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step (Probable) (PubMed:8344945). {ECO:0000269|PubMed:8344945, ECO:0000305|PubMed:3182818, ECO:0000305|PubMed:3680298}.
uniprot
proteins
mass_dalton
22486
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis. {ECO:0000305|PubMed:3680298}.
uniprot
proteins
protein_family
Class VI-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
PEMT/PEM2 methyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
3182818
uniprot
proteins
pubmed
3680298
uniprot
proteins
pubmed
8344945
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UBM1}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}. Mitochondrion membrane {ECO:0000255|HAMAP-Rule:MF_03216}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria (By similarity). Located in a unique membrane in the hepatocyte, which is not recognizable as any known subcellular structure (PubMed:8344945). {ECO:0000250|UniProtKB:Q9UBM1, ECO:0000269|PubMed:8344945}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..66; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03216"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03216"; TRANSMEM 158..178; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03216
uniprot
proteins