TPM4
entrez
7171
canonical
uniprot
P67936
canonical
ensembl
ENSG00000167460
resolver
ensp
ENSP00000467087
resolver
ensp
ENSP00000494125
resolver
ensp
ENSP00000494867
resolver
ensp
ENSP00000495347
resolver
ensp
ENSP00000495506
resolver
ensp
ENSP00000496574
resolver
ensp
ENSP00000715739
resolver
enst
ENST00000586833
resolver
enst
ENST00000645471
resolver
enst
ENST00000646575
resolver
enst
ENST00000647037
resolver
genesymbol
HEL-S-108
resolver
genesymbol
TPM4
resolver
hgnc
HGNC:12013
resolver
uniprot
A0A2R8Y5V9
resolver
uniprot
A0A2R8YH90
resolver
uniprot
K7ENT6
resolver
uniprot
P07226
resolver
uniprot
Q15659
resolver
uniprot
Q5U0D9
resolver
uniprot
Q9BU85
resolver
uniprot
Q9H8Q3
resolver
uniprot
Q9UCS1
resolver
uniprot
Q9UCS2
resolver
uniprot
Q9UCS3
resolver
uniprot
Q9UCS4
resolver
uniprot
V9HW56
resolver
uniprot_entry
A0A2R8Y5V9_HUMAN
resolver
uniprot_entry
K7ENT6_HUMAN
resolver
uniprot_entry
TPM4_HUMAN
resolver
uniprot_entry
V9HW56_HUMAN
resolver
uniprot_sec
A0A2R8YH90
resolver
uniprot_sec
P07226
resolver
uniprot_sec
Q15659
resolver
uniprot_sec
Q5U0D9
resolver
uniprot_sec
Q9BU85
resolver
uniprot_sec
Q9H8Q3
resolver
uniprot_sec
Q9UCS1
resolver
uniprot_sec
Q9UCS2
resolver
uniprot_sec
Q9UCS3
resolver
uniprot_sec
Q9UCS4
resolver
amino_acid_sequence
MAGLNSLEAVKRKIQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI
uniprot
proteins
disease_involvement
DISEASE: Bleeding disorder, platelet-type, 25 (BDPLT25) [MIM:620486]: An autosomal dominant disorder characterized by increased bleeding tendency due to decreased or dysfunctional platelets. Platelet morphologic and functional defects are variable. Some individuals have normal numbers of enlarged platelets. {ECO:0000269|PubMed:27479822, ECO:0000269|PubMed:28134622, ECO:0000269|PubMed:34758189, ECO:0000269|PubMed:35170221}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). Plays a role in platelet biogenesis. {ECO:0000250|UniProtKB:P09495, ECO:0000269|PubMed:1836432, ECO:0000269|PubMed:28134622, ECO:0000269|PubMed:35170221}.
uniprot
proteins
mass_dalton
28522
uniprot
proteins
protein_family
Tropomyosin family
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
1836432
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27479822
uniprot
proteins
pubmed
28134622
uniprot
proteins
pubmed
34758189
uniprot
proteins
pubmed
35170221
uniprot
proteins
pubmed
35596517
uniprot
proteins
pubmed
3612796
uniprot
proteins
pubmed
3865200
uniprot
proteins
sequence_length
248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P09495}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P09495}.
uniprot
proteins