Slc22a7
entrez
108114
canonical
uniprot
Q91WU2
canonical
ensembl
ENSMUSG00000067144
resolver
ensp
ENSMUSP00000084234
resolver
enst
ENSMUST00000087012
resolver
genesymbol
Slc22a7
resolver
genesymbol_syn
Oat2
resolver
uniprot
A0A0R4J122
resolver
uniprot
Q3UNX2
resolver
uniprot
Q8BUQ9
resolver
uniprot
Q8K4S9
resolver
uniprot
Q8R0M7
resolver
uniprot
Q8R125
resolver
uniprot_entry
A0A0R4J122_MOUSE
resolver
uniprot_entry
S22A7_MOUSE
resolver
uniprot_sec
Q3UNX2
resolver
uniprot_sec
Q8BUQ9
resolver
uniprot_sec
Q8K4S9
resolver
uniprot_sec
Q8R0M7
resolver
uniprot_sec
Q8R125
resolver
amino_acid_sequence
MGFEELLHKVGGFGPFQLRNLVLLALPRFLLPMHFLLPIFMAAVPAHHCALPDAPANLSHQDLWLKTHLPRETDGSFSSCLRFAYPQALPNVTLGTEVYNSGEPEGEPLTVPCSQGWEYDRSEFSSTIATEWDLVCEQRGLNKVTSTCFFIGVLLGAVVYGYLSDRFGRRRLLLVAYVSTLALGLMSAASVNYIMFVTTRMLTGSALAGFTIIVLPLELEWLDVEHRTVAGVISTTFWTGGVLLLTLVGYLIRSWRWLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLSICAKLNGRPISEDSLSQEALNKVITMERVSQRPSYLDLFRTSQLRHVSLCCMMMWFGVNFSYYGLTLDASGLGLTVYQTQLLFGAVEVPSKITVFFLVRLVGRRLTEAGMLLATALTFGISLLVSSDTKSWITALVVIGKAFSEAAFTTAYLFTSELYPTVLRQTGMGFTALIGRLGASLAPLVVLLDGVWLLLPKLAYGGISFLAACTVLLLPETKKAQLPETIQDVERKGRKIDRSGTELA
uniprot
proteins
function
FUNCTION: Functions as a Na(+)-independent bidirectional multispecific transporter (PubMed:12065749). Contributes to the renal and hepatic elimination of endogenous organic compounds from the systemic circulation into the urine and bile, respectively (PubMed:12065749). Capable of transporting a wide range of purine and pyrimidine nucleobases, nucleosides, and nucleotides with cGMP, 2'deoxyguanosine and GMP being the preferred substrates (By similarity). Functions as a pH- and chloride-independent cGMP bidirectional facilitative transporter that can regulate both intracellular and extracellular levels of cGMP and may be involved in cGMP signaling pathways (By similarity). Mediates orotate/glutamate bidirectional exchange and most likely display a physiological role in hepatic release of glutamate into the blood (By similarity). Involved in renal secretion and possible reabsorption of creatinine (By similarity). Able to uptake prostaglandin E2 (PGE2) and may contribute to PGE2 renal excretion (Probable). Also transports alpha-ketoglutarate and urate (PubMed:12065749). Unlike human hortolog, able to transport glutarate (PubMed:12065749). Apart from the orotate/glutamate exchange, the counterions for the uptake of other SLC22A7/OAT2 substrates remain to be identified (By similarity). {ECO:0000250|UniProtKB:Q9Y694, ECO:0000269|PubMed:12065749, ECO:0000305|PubMed:12065749}.
uniprot
proteins
mass_dalton
59614
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
12065749
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16256982
uniprot
proteins
pubmed
16885152
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
540
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:Q9Y694}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Y694}. Apical cell membrane {ECO:0000269|PubMed:16256982}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q9Y694}; Multi-pass membrane protein {ECO:0000305}. Note=Apical side of the renal tubule. {ECO:0000269|PubMed:16256982}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 257..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 378..398; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 402..422; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 429..449; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 462..484; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 488..510; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins