MC5R
entrez
4161
canonical
uniprot
P33032
canonical
ensembl
ENSG00000176136
resolver
ensp
ENSP00000318077
resolver
ensp
ENSP00000468086
resolver
enst
ENST00000324750
resolver
enst
ENST00000589410
resolver
genesymbol
MC5R
resolver
hgnc
HGNC:6933
resolver
uniprot
B0YJ34
resolver
uniprot
Q502V1
resolver
uniprot_entry
MC5R_HUMAN
resolver
uniprot_sec
B0YJ34
resolver
uniprot_sec
Q502V1
resolver
amino_acid_sequence
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for melanocyte-stimulating hormones (alpha- beta- and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:37524700, PubMed:8396929). Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway (PubMed:37524700). Also activates ERK1/2 via a PI3K-dependent signaling mechanism (PubMed:19428994). Order of potency of natural melanocortins in receptor activation is alpha-MSH > ACTH > beta-MSH > gamma-MSH (PubMed:8396929). Plays a key role in immune response, and is essential for temperature regulation and exocrine gland function (By similarity). {ECO:0000250|UniProtKB:P41149, ECO:0000269|PubMed:19428994, ECO:0000269|PubMed:37524700, ECO:0000269|PubMed:8396929}.
uniprot
proteins
mass_dalton
36601
uniprot
proteins
mutagenesis
MUTAGEN 92; /note="E->A: Over 100 fold decrease in alpha-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 99; /note="L->A: 10 to 100 fold alpha-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 115; /note="D->A,N: Impaired alpha-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 116; /note="N->A: 2 to 10 fold decrease in alpha-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 118; /note="F->A: 2 to 10 fold decrease in alpha-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 119; /note="D->A,N: Over 100 fold decrease in alpha-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 126; /note="V->A: 2 to 10 fold decrease in alpha-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 178; /note="I->A: Over 100 fold decrease in alpha-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 181; /note="S->A: 2 to 10 fold decrease in alpha-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 186; /note="V->A: 2 to 10 fold decrease in alpha-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 187; /note="I->A: 2 to 10 fold decrease in alpha-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 190; /note="L->A: 2 to 10 fold decrease in alpha-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 235; /note="Q->K: 10% increase of binding to alpha-MSH."; /evidence="ECO:0000269|PubMed:9240466"; MUTAGEN 254; /note="F->A: Over 100 fold decrease in alpha-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 272; /note="R->C: 690% increase of binding to alpha-MSH."; /evidence="ECO:0000269|PubMed:9240466"; MUTAGEN 277; /note="F->A: 10 to 100 fold decrease in alpha-MSH potency."; /evidence="ECO:0000269|PubMed:37524700"; MUTAGEN 281; /note="L->A: 10 to 100 fold decrease in alpha-MSH potency."; /evidence="ECO:0000269|PubMed:37524700
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11286624
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19428994
uniprot
proteins
pubmed
37524700
uniprot
proteins
pubmed
7739752
uniprot
proteins
pubmed
8179577
uniprot
proteins
pubmed
8396929
uniprot
proteins
pubmed
9240466
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 38..61; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 74..97; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 115..138; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 156..179; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 187..211; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 240..265; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 274..297; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins