SUGCT
entrez
79783
canonical
uniprot
Q9HAC7
canonical
ensembl
ENSG00000175600
resolver
ensp
ENSP00000338475
resolver
ensp
ENSP00000385222
resolver
ensp
ENSP00000486291
resolver
ensp
ENSP00000544559
resolver
ensp
ENSP00000544560
resolver
ensp
ENSP00000544561
resolver
ensp
ENSP00000781070
resolver
ensp
ENSP00000791009
resolver
genesymbol
SUGCT
resolver
genesymbol_syn
C7orf10
resolver
genesymbol_syn
DERP13
resolver
hgnc
HGNC:16001
resolver
uniprot
A4D1W5
resolver
uniprot
B4DJF0
resolver
uniprot
B4DR73
resolver
uniprot
Q4KMW4
resolver
uniprot
Q4KMW8
resolver
uniprot
Q4KMZ0
resolver
uniprot
Q8TE00
resolver
uniprot
Q8TEY1
resolver
uniprot_entry
SUCHY_HUMAN
resolver
uniprot_sec
A4D1W5
resolver
uniprot_sec
B4DJF0
resolver
uniprot_sec
B4DR73
resolver
uniprot_sec
Q4KMW4
resolver
uniprot_sec
Q4KMW8
resolver
uniprot_sec
Q4KMZ0
resolver
uniprot_sec
Q8TE00
resolver
uniprot_sec
Q8TEY1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by valsartan and losartan carboxylate. {ECO:0000269|PubMed:38915184}.
uniprot
proteins
amino_acid_sequence
MLATLARVAALRRTCLFSGRGGGRGLWTGRPQSDMNNIKPLEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGAGDDTRTWGPPFVGTESTYYLSVNRNKKSIAVNIKDPKGVKIIKELAAVCDVFVENYVPGKLSAMGLGYEDIDEIAPHIIYCSITGYGQTGPISQRAGYDAVASAVSGLMHITGPENGDPVRPGVAMTDLATGLYAYGAIMAGLIQKYKTGKGLFIDCNLLSSQVACLSHIAANYLIGQKEAKRWGTAHGSIVPYQAFKTKDGYIVVGAGNNQQFATVCKILDLPELIDNSKYKTNHLRVHNRKELIKILSERFEEELTSKWLYLFEGSGVPYGPINNMKNVFAEPQVLHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQHTTHILKEVLRYDDRAIGELLSAGVVDQHETH
uniprot
proteins
disease_involvement
DISEASE: Glutaric aciduria 3 (GA3) [MIM:231690]: An autosomal recessive metabolic condition characterized by urinary excretion of abnormal quantities of glutaric acid, in the presence of normal 3-hydroxyglutarate, glutarylcarnitine and glutarylglycine urinary levels. Affected individuals show no consistent clinical phenotype and many are asymptomatic. {ECO:0000269|PubMed:18926513, ECO:0000269|PubMed:23893049}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.8.3.-
uniprot
proteins
ec_number
2.8.3.13
uniprot
proteins
function
FUNCTION: Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and glutarate, succinate, adipate/hexanedioate, itaconate and 3-hydroxy-3-methylglutarate as dicarboxylate acceptors (PubMed:23893049, PubMed:34492704, PubMed:38915184). Acts on intermediates or end products of lysine and tryptophan degradation pathway, in particular catalyzes succinyl-CoA-dependent reesterification of free glutarate into glutaryl-CoA to prevent renal excretion of glutarate (PubMed:18926513, PubMed:23893049, PubMed:38915184). Upon inflammation, may convert macrophage-derived itaconate to itaconyl-CoA in erythroid precursors where it negatively regulates the TCA cycle and heme synthesis to limit erythroid differentiation in the context of stress erythropoiesis (PubMed:34492704). {ECO:0000269|PubMed:18926513, ECO:0000269|PubMed:23893049, ECO:0000269|PubMed:34492704, ECO:0000269|PubMed:38915184}.
uniprot
proteins
mass_dalton
47708
uniprot
proteins
mutagenesis
MUTAGEN 205; /note="D->A: Loss of CoA transferase activity toward glutaryl-CoA and 3-hydroxy-3-methylglutarate substrates."; /evidence="ECO:0000269|PubMed:38915184
uniprot
proteins
protein_family
CoA-transferase III family
uniprot
proteins
pubmed
11829489
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18926513
uniprot
proteins
pubmed
19880432
uniprot
proteins
pubmed
23893049
uniprot
proteins
pubmed
34492704
uniprot
proteins
pubmed
38915184
uniprot
proteins
sequence_length
438
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23893049, ECO:0000269|PubMed:34492704}.
uniprot
proteins