GGA1
entrez
26088
canonical
uniprot
Q9UJY5
canonical
ensembl
ENSG00000100083
resolver
ensp
ENSP00000321288
resolver
ensp
ENSP00000341344
resolver
ensp
ENSP00000371175
resolver
ensp
ENSP00000385287
resolver
ensp
ENSP00000521346
resolver
ensp
ENSP00000627721
resolver
ensp
ENSP00000646114
resolver
genesymbol
GGA1
resolver
hgnc
HGNC:17842
resolver
uniprot
A8K3D3
resolver
uniprot
B0QYR7
resolver
uniprot
Q5R3N1
resolver
uniprot
Q5TG07
resolver
uniprot
Q6IC75
resolver
uniprot
Q86YA9
resolver
uniprot
Q8NCS6
resolver
uniprot
Q9BW94
resolver
uniprot
Q9UG00
resolver
uniprot
Q9UGW0
resolver
uniprot
Q9UGW1
resolver
uniprot_entry
GGA1_HUMAN
resolver
uniprot_sec
A8K3D3
resolver
uniprot_sec
B0QYR7
resolver
uniprot_sec
Q5R3N1
resolver
uniprot_sec
Q5TG07
resolver
uniprot_sec
Q6IC75
resolver
uniprot_sec
Q86YA9
resolver
uniprot_sec
Q8NCS6
resolver
uniprot_sec
Q9BW94
resolver
uniprot_sec
Q9UG00
resolver
uniprot_sec
Q9UGW0
resolver
uniprot_sec
Q9UGW1
resolver
amino_acid_sequence
MEPAMEPETLEARINRATNPLNKELDWASINGFCEQLNEDFEGPPLATRLLAHKIQSPQEWEAIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKNKILELLYSWTVGLPEEVKIAEAYQMLKKQGIVKSDPKLPDDTTFPLPPPRPKNVIFEDEEKSKMLARLLKSSHPEDLRAANKLIKEMVQEDQKRMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGGAAAGSSEDLMKELYQRCERMRPTLFRLASDTEDNDEALAEILQANDNLTQVINLYKQLVRGEEVNGDATAGSIPGSTSALLDLSGLDLPPAGTTYPAMPTRPGEQASPEQPSASVSLLDDELMSLGLSDPTPPSGPSLDGTGWNSFQSSDATEPPAPALAQAPSMESRPPAQTSLPASSGLDDLDLLGKTLLQQSLPPESQQVRWEKQQPTPRLTLRDLQNKSSSCSSPSSSATSLLHTVSPEPPRPPQQPVPTELSLASITVPLESIKPSNILPVTVYDQHGFRILFHFARDPLPGRSDVLVVVVSMLSTAPQPIRNIVFQSAVPKVMKVKLQPPSGTELPAFNPIVHPSAITQVLLLANPQKEKVRLRYKLTFTMGDQTYNEMGDVDQFPPPETWGSL
uniprot
proteins
function
FUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712, PubMed:15886016). {ECO:0000250|UniProtKB:Q8R0H9, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:15886016, ECO:0000269|PubMed:27901063}.
uniprot
proteins
mass_dalton
70384
uniprot
proteins
mutagenesis
MUTAGEN 92; /note="N->A: Abolishes interaction with IGF2R."; /evidence="ECO:0000269|PubMed:12060753"; MUTAGEN 182; /note="L->A: Abolishes interaction with ARF1, UBC and TSG101."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 194; /note="N->A: Abolishes interaction with ARF1 and RABEP1."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 197; /note="I->A: Abolishes interaction with ARF1, UBC and TSG101."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 198; /note="K->A: Abolishes interaction with ARF1."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 200; /note="M->A: Abolishes interaction with ARF1."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 204; /note="D->A: Abolishes interaction with ARF1."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 259; /note="M->K: Abolishes interaction with RABEP1."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 260; /note="R->A: No effect on interaction with RABEP1."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 260; /note="R->E: Abolishes interaction with RABEP1 and UBC."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 264; /note="F->A: Abolishes interaction with RABEP1."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 267; /note="A->D: Abolishes interaction with RABEP1 and UBC."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 277; /note="L->A: Abolishes interaction with RABEP1, UBC and TSG101."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 281; /note="L->A: Abolishes interaction with RABEP1."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 284; /note="N->A: Abolishes interaction with RABEP1."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 284; /note="N->S: Abolishes interaction with RABEP1."; /evidence="ECO:0000269|PubMed:15143060"; MUTAGEN 355; /note="S->A: Increased interaction with IGF2R. Reduced phosphorylation. No effect on the interaction with SORL1."; /evidence="ECO:0000269|PubMed:12060753, ECO:0000269|PubMed:20015111"; MUTAGEN 355; /note="S->D: Abolishes interaction with IGF2R. No effect on the interaction with SORL1."; /evidence="ECO:0000269|PubMed:12060753, ECO:0000269|PubMed:20015111"; MUTAGEN 356..360; /note="LLDDE->AADAA: Partial loss of clathrin-binding."; /evidence="ECO:0000269|PubMed:11301005"; MUTAGEN 358; /note="D->A: Increased interaction with IGF2R."; /evidence="ECO:0000269|PubMed:12060753"; MUTAGEN 361..362; /note="LM->AA: Increased interaction with IGF2R."; /evidence="ECO:0000269|PubMed:12060753"; MUTAGEN 563; /note="A->D: Abolishes interaction with CCDC91."; /evidence="ECO:0000269|PubMed:12808037"; MUTAGEN 564; /note="V->D: Abolishes interaction with CCDC91."; /evidence="ECO:0000269|PubMed:12808037"; MUTAGEN 570; /note="V->E: Abolishes interaction with CCDC91."; /evidence="ECO:0000269|PubMed:12808037"; MUTAGEN 572; /note="L->E: Abolishes interaction with CCDC91."; /evidence="ECO:0000269|PubMed:12808037
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CK2 and dephosphorylated by PP2A. Phosphorylation of GGA1 allows the internal DXXLL motif to bind the VHS domain and to inhibit the recognition of cargo signals. {ECO:0000269|PubMed:12060753}.; PTM: Ubiquitinated. {ECO:0000250}.
uniprot
proteins
protein_family
GGA protein family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10747088
uniprot
proteins
pubmed
10747089
uniprot
proteins
pubmed
10749927
uniprot
proteins
pubmed
10814529
uniprot
proteins
pubmed
11301005
uniprot
proteins
pubmed
11387475
uniprot
proteins
pubmed
11390366
uniprot
proteins
pubmed
11821067
uniprot
proteins
pubmed
11859376
uniprot
proteins
pubmed
11950392
uniprot
proteins
pubmed
12060753
uniprot
proteins
pubmed
12505986
uniprot
proteins
pubmed
12538641
uniprot
proteins
pubmed
12578827
uniprot
proteins
pubmed
12679809
uniprot
proteins
pubmed
12808037
uniprot
proteins
pubmed
12858163
uniprot
proteins
pubmed
14567678
uniprot
proteins
pubmed
14638859
uniprot
proteins
pubmed
14660606
uniprot
proteins
pubmed
14665628
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15039775
uniprot
proteins
pubmed
15143060
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15615712
uniprot
proteins
pubmed
15758025
uniprot
proteins
pubmed
15886016
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17855360
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20015111
uniprot
proteins
pubmed
20676133
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22522702
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27901063
uniprot
proteins
sequence_length
639
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15886016}; Peripheral membrane protein. Endosome membrane {ECO:0000269|PubMed:15886016}; Peripheral membrane protein. Early endosome membrane {ECO:0000269|PubMed:15886016}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins