HEL57
entrez
1992
canonical
uniprot
P30740
canonical
ensembl
ENSG00000021355
resolver
ensp
ENSP00000370115
resolver
ensp
ENSP00000548970
resolver
ensp
ENSP00000548972
resolver
genesymbol
HEL57
resolver
genesymbol
SERPINB1
resolver
genesymbol_syn
ELANH2
resolver
genesymbol_syn
HEL-S-27
resolver
genesymbol_syn
MNEI
resolver
genesymbol_syn
PI2
resolver
genesymbol_syn
SERPINB1
resolver
hgnc
HGNC:3311
resolver
uniprot
A8K5L2
resolver
uniprot
B4DNT0
resolver
uniprot
Q53FB9
resolver
uniprot
Q5W0E1
resolver
uniprot
Q9UDF8
resolver
uniprot
V9HWH1
resolver
uniprot_entry
ILEU_HUMAN
resolver
uniprot_entry
V9HWH1_HUMAN
resolver
uniprot_sec
A8K5L2
resolver
uniprot_sec
B4DNT0
resolver
uniprot_sec
Q53FB9
resolver
uniprot_sec
Q5W0E1
resolver
uniprot_sec
Q9UDF8
resolver
amino_acid_sequence
MEQLSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFNTVEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMLMPEENFTADHPFLFFIRHNSSGSILFLGRFSSP
uniprot
proteins
function
FUNCTION: Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651). {ECO:0000269|PubMed:11747453, ECO:0000269|PubMed:23269243, ECO:0000269|PubMed:26701651, ECO:0000269|PubMed:30692621}.
uniprot
proteins
mass_dalton
42742
uniprot
proteins
mutagenesis
MUTAGEN 343; /note="F->A: Loss of proteinase-3-binding activity but caspase-binding activity remains unaffected; in association with A-344."; /evidence="ECO:0000269|PubMed:30692621"; MUTAGEN 344; /note="C->A: Loss of proteinase-3-binding activity but caspase-binding activity remains unaffected; in association with A-343."; /evidence="ECO:0000269|PubMed:30692621
uniprot
proteins
protein_family
Ov-serpin subfamily
uniprot
proteins
protein_family
Serpin family
uniprot
proteins
pubmed
11747453
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
1376927
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21248149
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23269243
uniprot
proteins
pubmed
26701651
uniprot
proteins
pubmed
30692621
uniprot
proteins
pubmed
7578269
uniprot
proteins
pubmed
9630619
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26701651}. Cytoplasm {ECO:0000269|PubMed:23269243}. Cytolytic granule {ECO:0000269|PubMed:23269243}. Early endosome {ECO:0000269|PubMed:23269243}.
uniprot
proteins