Dlc1
entrez
50768
canonical
uniprot
Q9R0Z9
canonical
ensembl
ENSMUSG00000031523
resolver
ensp
ENSMUSP00000033923
resolver
ensp
ENSMUSP00000096425
resolver
ensp
ENSMUSP00000132812
resolver
ensp
ENSMUSP00000293431
resolver
ensp
ENSMUSP00000293432
resolver
enst
ENSMUST00000033923
resolver
enst
ENSMUST00000098826
resolver
enst
ENSMUST00000163663
resolver
genesymbol
Dlc1
resolver
genesymbol_syn
Arhgap7
resolver
genesymbol_syn
Stard12
resolver
uniprot
A0A0R4J171
resolver
uniprot
D5M8I5
resolver
uniprot
E9PXD2
resolver
uniprot
E9QKB1
resolver
uniprot
Q3TRX3
resolver
uniprot
Q3UH75
resolver
uniprot
Q8R541
resolver
uniprot_entry
A0A0R4J171_MOUSE
resolver
uniprot_entry
D5M8I5_MOUSE
resolver
uniprot_entry
E9PXD2_MOUSE
resolver
uniprot_entry
E9QKB1_MOUSE
resolver
uniprot_entry
RHG07_MOUSE
resolver
uniprot_sec
Q3TRX3
resolver
uniprot_sec
Q3UH75
resolver
uniprot_sec
Q8R541
resolver
amino_acid_sequence
MCRDEPDTMILTQIEAKEACDWLRVTGFPQYAQLYEDLLFPVDIALVKREHDFLDRDAIEALCRRLNTLNKCAVMKLEISPHRKRSEDSDEDEPCAISGKWTFQRDSKRWSRLEEFDVFFPKQDPIPGSPDNSRLQSATSHESMLTDLSEHQEVASVRSLSSTSSSVPTHAAHSGDATTPRTNSVISVCSSGHFVGNDDSFSSLPSPKELSSFSFSMKGHHEKNTKSKTRSLLKRMESLKLKGSHHSKHKAPSKLGLIISAPILQEGMDEAKLKQLNCVEISALNGNHINVPMVRKRSVSNSTQTSSSSSQSETSSAVSTPSPVTRTRSLSTCNKRVGMYLEGFDPFSQSTLNNVTEQNYKNRESYPEDTVFYIPEDHKPGTFPKALSHGSFCPSGNSSVNWRTGSFHGPGHLSLRRENSHDSPKELKRRNSSSSLSSRLSIYDNVPGSILYSSSGELADLENEDIFPELDDILYHVKGMQRIVNQWSEKFSDEGDSDSALDSVSPCPSSPKQIHLDVDHDRRTPSDLDSTGNSLNEPEEPTDIPERRDSGVGASLTRCNRHRLRWHSFQSSHRPSLNSVSLQINCQSVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYKDRSVFGVPLTVNVQRSGQPLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNESAEDNVNYEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAPSLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAECKKLFQVPEEMSRCRNSYTEQELKPLTLEALGHLNSDQPADYRHFLQDCVDGLFKEVKEKFKGWVSYPTSEQADLSYKKVSEGPPLRLWRSTIEVPAAPEEILKRLLKEQHLWDVDLLDSKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNLPRGACALLLTSVDHDRAPVAGVRVNVLLSRYLIEPCGSGKSKLTYMCRADLRGHMPEWYSKSFGHLCAAEVVKIRDSFSNQNTESKDTRSR
uniprot
proteins
function
FUNCTION: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity). Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (By similarity). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (By similarity). {ECO:0000250|UniProtKB:Q96QB1}.
uniprot
proteins
mass_dalton
123367
uniprot
proteins
pubmed
10702663
uniprot
proteins
pubmed
12034501
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1092
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q96QB1}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery. {ECO:0000250}.
uniprot
proteins