Nrxn1
entrez
18189
canonical
uniprot
P0DI97
canonical
uniprot
Q9CS84
canonical
ensembl
ENSMUSG00000024109
resolver
ensp
ENSMUSP00000057294
resolver
ensp
ENSMUSP00000072458
resolver
ensp
ENSMUSP00000124561
resolver
ensp
ENSMUSP00000125407
resolver
ensp
ENSMUSP00000125561
resolver
ensp
ENSMUSP00000133389
resolver
ensp
ENSMUSP00000133491
resolver
ensp
ENSMUSP00000133724
resolver
ensp
ENSMUSP00000134402
resolver
ensp
ENSMUSP00000142815
resolver
enst
ENSMUST00000159778
resolver
enst
ENSMUST00000160800
resolver
enst
ENSMUST00000172466
resolver
enst
ENSMUST00000173917
resolver
enst
ENSMUST00000174337
resolver
genesymbol
Nrxn1
resolver
genesymbol_syn
Kiaa0578
resolver
uniprot
A0A0H2UH29
resolver
uniprot
E0CY11
resolver
uniprot
E0CZA5
resolver
uniprot
G3UWQ9
resolver
uniprot
G3UWZ9
resolver
uniprot
O88722
resolver
uniprot
Q80Y87
resolver
uniprot
Q8CHE6
resolver
uniprot_entry
A0A0H2UH29_MOUSE
resolver
uniprot_entry
E0CY11_MOUSE
resolver
uniprot_entry
E0CZA5_MOUSE
resolver
uniprot_entry
G3UWQ9_MOUSE
resolver
uniprot_entry
NRX1A_MOUSE
resolver
uniprot_entry
NRX1B_MOUSE
resolver
uniprot_sec
G3UWZ9
resolver
uniprot_sec
O88722
resolver
uniprot_sec
Q80Y87
resolver
uniprot_sec
Q8CHE6
resolver
amino_acid_sequence
MGTALVQRGGCCLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQALPVDGGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEIQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSANKNKKNKDKEYYV
uniprot
proteins
amino_acid_sequence
MYQRMLRCGADLGSPGGGSGGGAGGRLALIWIVPLTLSGLLGVAWGASSLGAHHIHHFHGSSKHHSVPIAIYRSPASLRGGHAGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSANKNKKNKDKEYYV
uniprot
proteins
function
FUNCTION: Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may affect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom. {ECO:0000269|PubMed:12827191, ECO:0000269|PubMed:14983056, ECO:0000269|PubMed:16406382, ECO:0000269|PubMed:17035546, ECO:0000269|PubMed:21410790, ECO:0000269|PubMed:30100184, ECO:0000269|PubMed:9430716}.
uniprot
proteins
function
FUNCTION: Neuronal cell surface protein involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins (By similarity). Plays a role in formation of synaptic junctions (PubMed:30100184). Functions as part of a trans-synaptic complex by binding to cerebellins and postsynaptic GRID1. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN1B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic NMDAR response (PubMed:34135511). {ECO:0000250|UniProtKB:Q63373, ECO:0000269|PubMed:30100184, ECO:0000269|PubMed:34135511}.
uniprot
proteins
mass_dalton
166169
uniprot
proteins
mass_dalton
50223
uniprot
proteins
mutagenesis
MUTAGEN 137; /note="D->A: Loss of NLGN1-binding. No effect on CBLN1-binding."; /evidence="ECO:0000269|PubMed:21410790"; MUTAGEN 238; /note="N->A: Loss of NLGN1-binding. No effect on CBLN1-binding."; /evidence="ECO:0000269|PubMed:21410790"; MUTAGEN 346; /note="S->A: Abolishes heparan sulfate attachment. Does not affect cell surface location."; /evidence="ECO:0000269|PubMed:30100184"; MUTAGEN 362..363; /note="SS->AA: No effect on heparan sulfate attachment."; /evidence="ECO:0000269|PubMed:30100184
uniprot
proteins
mutagenesis
MUTAGEN 1392; /note="S->A: Abolishes heparan sulfate attachment."; /evidence="ECO:0000269|PubMed:30100184
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins and LRRTM2. {ECO:0000269|PubMed:30100184}.
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins. {ECO:0000269|PubMed:30100184}.
uniprot
proteins
protein_family
Neurexin family
uniprot
proteins
pubmed
10408888
uniprot
proteins
pubmed
11171101
uniprot
proteins
pubmed
11243866
uniprot
proteins
pubmed
12465718
uniprot
proteins
pubmed
12827191
uniprot
proteins
pubmed
14983056
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16406382
uniprot
proteins
pubmed
17035546
uniprot
proteins
pubmed
17347997
uniprot
proteins
pubmed
18334216
uniprot
proteins
pubmed
18434543
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19822762
uniprot
proteins
pubmed
20624592
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21410790
uniprot
proteins
pubmed
22220752
uniprot
proteins
pubmed
24094106
uniprot
proteins
pubmed
24613359
uniprot
proteins
pubmed
25385611
uniprot
proteins
pubmed
25737549
uniprot
proteins
pubmed
29782851
uniprot
proteins
pubmed
30100184
uniprot
proteins
pubmed
32434929
uniprot
proteins
pubmed
34135511
uniprot
proteins
pubmed
9430716
uniprot
proteins
sequence_length
1514
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000269|PubMed:21410790}; Single-pass type I membrane protein {ECO:0000269|PubMed:21410790}.
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000269|PubMed:34135511}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 1439..1459; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins
transmembrane_region
TRANSMEM 393..413; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins