CCT5
entrez
22948
canonical
uniprot
P48643
canonical
ensembl
ENSG00000150753
resolver
ensp
ENSP00000280326
resolver
ensp
ENSP00000423052
resolver
ensp
ENSP00000423318
resolver
ensp
ENSP00000426923
resolver
ensp
ENSP00000427297
resolver
enst
ENST00000503026
resolver
enst
ENST00000515390
resolver
enst
ENST00000515676
resolver
genesymbol
CCT5
resolver
genesymbol
HEL-S-69
resolver
genesymbol_syn
CCTE
resolver
genesymbol_syn
KIAA0098
resolver
hgnc
HGNC:1618
resolver
uniprot
A8JZY8
resolver
uniprot
A8K2X8
resolver
uniprot
B4DDU6
resolver
uniprot
B4DX08
resolver
uniprot
B4DYC8
resolver
uniprot
B4DYD8
resolver
uniprot
B7ZAR1
resolver
uniprot
E7ENZ3
resolver
uniprot
E9PCA1
resolver
uniprot
F6RJQ0
resolver
uniprot
V9HW37
resolver
uniprot_entry
B4DDU6_HUMAN
resolver
uniprot_entry
B4DX08_HUMAN
resolver
uniprot_entry
B4DYC8_HUMAN
resolver
uniprot_entry
B7ZAR1_HUMAN
resolver
uniprot_entry
E7ENZ3_HUMAN
resolver
uniprot_entry
E9PCA1_HUMAN
resolver
uniprot_entry
F6RJQ0_HUMAN
resolver
uniprot_entry
TCPE_HUMAN
resolver
uniprot_entry
V9HW37_HUMAN
resolver
uniprot_sec
A8JZY8
resolver
uniprot_sec
A8K2X8
resolver
uniprot_sec
B4DYD8
resolver
amino_acid_sequence
MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE
uniprot
proteins
disease_involvement
DISEASE: Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP) [MIM:256840]: A disease characterized by spastic paraplegia and progressive distal sensory neuropathy leading to mutilating ulcerations of the upper and lower limbs. {ECO:0000269|PubMed:16399879}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=De novo genetic variants in nearly every subunit of the TRiC complex, including CCT5, have been found in individuals with a broad spectrum of brain malformations, and clinical phenotypes ranging from mild to severe epilepsy, developmental delay, intellectual disability, ataxia, and other features of cerebral malfunction. {ECO:0000269|PubMed:39480921}.
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
function
FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
uniprot
proteins
mass_dalton
59671
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the DCX(DCAF12) complex specifically recognizes the diglutamate (Glu-Glu) at the C-terminus, leading to its degradation. {ECO:0000269|PubMed:29779948}.
uniprot
proteins
protein_family
TCP-1 chaperonin family
uniprot
proteins
pubmed
14532270
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16399879
uniprot
proteins
pubmed
16548883
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20080638
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23612981
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25467444
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29779948
uniprot
proteins
pubmed
33144677
uniprot
proteins
pubmed
35449234
uniprot
proteins
pubmed
36493755
uniprot
proteins
pubmed
37193829
uniprot
proteins
pubmed
39480921
uniprot
proteins
pubmed
7788527
uniprot
proteins
sequence_length
541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20080638}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20080638}.
uniprot
proteins