CNOT6
entrez
57472
canonical
uniprot
Q9ULM6
canonical
ensembl
ENSG00000113300
resolver
ensp
ENSP00000261951
resolver
ensp
ENSP00000377024
resolver
ensp
ENSP00000481893
resolver
ensp
ENSP00000638076
resolver
ensp
ENSP00000638077
resolver
ensp
ENSP00000792893
resolver
ensp
ENSP00000792894
resolver
enst
ENST00000261951
resolver
enst
ENST00000393356
resolver
enst
ENST00000618123
resolver
enst
ENST00000968018
resolver
genesymbol
CNOT6
resolver
genesymbol_syn
CCR4
resolver
genesymbol_syn
CCR4a
resolver
genesymbol_syn
KIAA1194
resolver
hgnc
HGNC:14099
resolver
uniprot
A7MD46
resolver
uniprot
D3DWR0
resolver
uniprot_entry
CNOT6_HUMAN
resolver
uniprot_sec
A7MD46
resolver
uniprot_sec
D3DWR0
resolver
amino_acid_sequence
MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEPDRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEVETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANAHMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSGVVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYTNYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLELLLPFLPQVNGIHLPGRR
uniprot
proteins
ec_number
3.1.13.4
uniprot
proteins
function
FUNCTION: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000269|PubMed:11889047, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:21233283}.
uniprot
proteins
mass_dalton
63307
uniprot
proteins
mutagenesis
MUTAGEN 240; /note="E->A: Impairs deadenylation and decay of mRNAi-targeted mRNA."; /evidence="ECO:0000269|PubMed:20065043
uniprot
proteins
protein_family
CCR4/nocturin family
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
11747467
uniprot
proteins
pubmed
11889047
uniprot
proteins
pubmed
15314026
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15687258
uniprot
proteins
pubmed
18180299
uniprot
proteins
pubmed
19558367
uniprot
proteins
pubmed
20065043
uniprot
proteins
pubmed
21233283
uniprot
proteins
sequence_length
557
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96LI5}. Nucleus {ECO:0000250|UniProtKB:Q96LI5}. Note=Predominantly cytoplasmic. {ECO:0000250|UniProtKB:Q96LI5}.
uniprot
proteins