Dok3
entrez
306760
canonical
uniprot
B2RYG7
canonical
ensembl
ENSRNOG00000013564
resolver
ensembl
ENSRNOG00060022268
resolver
ensembl
ENSRNOG00065022252
resolver
ensp
ENSRNOP00000018232
resolver
ensp
ENSRNOP00000079980
resolver
ensp
ENSRNOP00060031859
resolver
ensp
ENSRNOP00065030695
resolver
enst
ENSRNOT00000112507
resolver
enst
ENSRNOT00060038600
resolver
enst
ENSRNOT00065037939
resolver
genesymbol
Dok3
resolver
uniprot_entry
DOK3_RAT
resolver
amino_acid_sequence
MESVETPVKDGLLYQQHMKFGKKCWRKVWALLYAGGPSGVARLESWDVRDGGLGPGGDRPAGPGRRGERRIIRLADCVSVLPADGESCPRDTGAFLITTTERSHLLAAQHRQSWMDPICQLAFPSTGECSSGSGQAESPKRGFVPMEENSIYSSWQEVAEFPVVVQRTEATTRCQLKGPYLLVLGQDDIQLRETSKPQACYSWPYRFLRKFGSDKGVFSFEAGRRCDSGEGLFAFSSPRAPDICGAVAAAIARQRERLPELAMSPPCPLPRALSLPSLEPPGELREVAPEYELAPSRKLPLTDPGPQSLPLLLSPTQDGTASSLYASVCKQTSKHKATVEHLYENVFMLEASPGLSNGGPEAQEGPPGGRSPLGSPIYHNSEELSWPGSAHDSNLEAQYRRLLELELDDAGGAGRPGAQTGIKAKLVTLLTRERKKGPAPCDRP
uniprot
proteins
function
FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
48190
uniprot
proteins
post_translational_modification
PTM: Constitutively tyrosine-phosphorylated. {ECO:0000250}.; PTM: On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
DOK family
uniprot
proteins
protein_family
Type A subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
444
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
uniprot
proteins