P2RX3
entrez
5024
canonical
uniprot
P56373
canonical
ensembl
ENSG00000109991
resolver
ensp
ENSP00000263314
resolver
ensp
ENSP00000562468
resolver
enst
ENST00000263314
resolver
genesymbol
P2RX3
resolver
hgnc
HGNC:8534
resolver
uniprot
Q6DK37
resolver
uniprot
Q9UQB6
resolver
uniprot_entry
P2RX3_HUMAN
resolver
uniprot_sec
Q6DK37
resolver
uniprot_sec
Q9UQB6
resolver
activity_regulation
ACTIVITY REGULATION: Has high sensitivity to ATP. Fast activation by external ATP. Exhibits rapid desensitization. Sensitives to the ATP agonist:alpha/beta-methylene-ATP (PubMed:10440098). Subject to allosteric inhibition by AF-219 (PubMed:29674445). Mg(2+) and Ca(2+) slow deactivation of P2RX3 (PubMed:31232692). {ECO:0000269|PubMed:10440098, ECO:0000269|PubMed:29674445, ECO:0000269|PubMed:31232692}.
uniprot
proteins
amino_acid_sequence
MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
uniprot
proteins
function
FUNCTION: Extracellular ATP-activated non-selective cation channel (PubMed:10440098, PubMed:27626375, PubMed:29674445, PubMed:31232692). Plays particularly important role in sensory neurons where its activation is critical for gustatory, nociceptive responses, visceral reflexes and sensory hypersensitization (By similarity). {ECO:0000250|UniProtKB:Q3UR32, ECO:0000269|PubMed:10440098, ECO:0000269|PubMed:27626375, ECO:0000269|PubMed:29674445, ECO:0000269|PubMed:31232692}.
uniprot
proteins
mass_dalton
44289
uniprot
proteins
mutagenesis
MUTAGEN 61; /note="V->R: Decreases sensitivity to the allosteric inhibitor AF-219."; /evidence="ECO:0000269|PubMed:29674445"; MUTAGEN 176; /note="K->R: Does not affect the inhibition the allosteric inhibitor AF-219."; /evidence="ECO:0000269|PubMed:29674445"; MUTAGEN 178; /note="S->F: Does not affect the inhibition the allosteric inhibitor AF-219."; /evidence="ECO:0000269|PubMed:29674445"; MUTAGEN 189; /note="G->A: Abolishes the inhibition by the allosteric inhibitor AF-219."; /evidence="ECO:0000269|PubMed:29674445"; MUTAGEN 190; /note="N->A: Decreases sensitivity to the allosteric inhibitor AF-219."; /evidence="ECO:0000269|PubMed:29674445"; MUTAGEN 238; /note="V->L: Decreases sensitivity to the allosteric inhibitor AF-219."; /evidence="ECO:0000269|PubMed:29674445"; MUTAGEN 264; /note="R->A: Decreases sensitivity to the allosteric inhibitor AF-219."; /evidence="ECO:0000269|PubMed:29674445"; MUTAGEN 265; /note="L->W: Decreases sensitivity to the allosteric inhibitor AF-219."; /evidence="ECO:0000269|PubMed:29674445"; MUTAGEN 267; /note="S->A: Does not affect the inhibition he allosteric inhibitor AF-219."; /evidence="ECO:0000269|PubMed:29674445
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
10440098
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
27626375
uniprot
proteins
pubmed
29674445
uniprot
proteins
pubmed
31232692
uniprot
proteins
pubmed
9016352
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27626375}; Multi-pass membrane protein {ECO:0000269|PubMed:27626375}. Note=Localizes to neuronal cell body of sensory neurons. {ECO:0000250|UniProtKB:P49654}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..43; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:27626375"; TRANSMEM 323..341; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:27626375
uniprot
proteins