Atp2c2
entrez
69047
canonical
uniprot
A7L9Z8
canonical
ensembl
ENSMUSG00000034112
resolver
ensp
ENSMUSP00000092794
resolver
enst
ENSMUST00000095171
resolver
genesymbol
Atp2c2
resolver
genesymbol_syn
Kiaa0703
resolver
genesymbol_syn
Spca2
resolver
uniprot
Q5DU19
resolver
uniprot_entry
AT2C2_MOUSE
resolver
uniprot_sec
Q5DU19
resolver
amino_acid_sequence
MGRRLKFLQKLAFLGQNHRYKALERDEVETLIDEQCELKAIEREKTVAALPPGEACKCSREELARAFHVDLDSGLSEFAVAQRRLVHGWNEFVTDNAEPVWKKYLDQFRNPLILLLLGSSVVSVLTKEYEDAVSIALAVLIVVTVGFIQEYRSEKSLEELTKLVPPECNCLRDGKLRHMLARDLVPGDIVSLSMGDRIPADIRLTEVTDLLVDESSFTGEVEPCGKTDSPLADGGDLSTLSNVVFMGTLVQCGKGQGVVIGTGEQSQFGEVFKMMRAEETPKTPLQKSMDKLGKQLTIFSFGIIGLLMLVGWVQGKPFLSMFTVGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCNVICSDKTGTLTANEMTATQLVTSDGFHAEVSGVGYSGEGTVCLLPSKEVIKGFDNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALVVLAMKMNLGSIKDSYVRKKEIPFSSEQKWMAVRCGPKSEDGEDIYFMKGAFEEVIHHCSMYNNGGIPLPLTPQQKSYCQQEEKKMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRAGVKEAVQVLSESGVSVKMVTGDALETALAIGRTIGLCNEKLKAMSGEEVEGTEQGALAARVRQVSVFFRTSPKHKVKIIKALQESGAIVAMTGDGVNDSVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMSAVEEGKGIFYNIKNFVRFQLSTSIAALSLITLSTVCNLPSPLNAMQILWVNIIMDGPPAQSLGVEPVDRDALRRPPRSVGDTILNRALILRVLMSAAVIIGGTLFIFWREIPANGTSTPRTTTMAFTCFVFFDLFNALSCRSQTKLIFEIGFFRNRMFLYSVLGSLLGQLAVIYAPPLQKVFQTENLSALDLLLLTGLASSVFILSELLKLWEKFLSRARPTQMLPEAV
uniprot
proteins
ec_number
7.2.2.10
uniprot
proteins
function
FUNCTION: ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (By similarity). Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May facilitate transepithelial transport of large quantities of Ca(2+) for milk secretion via activation of Ca(2+) influx channels at the plasma membrane and active Ca(2+) transport at the Golgi apparatus (By similarity) (PubMed:23840669). {ECO:0000250|UniProtKB:O75185, ECO:0000269|PubMed:23840669}.
uniprot
proteins
mass_dalton
102528
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIA subfamily
uniprot
proteins
pubmed
15677451
uniprot
proteins
pubmed
23840669
uniprot
proteins
sequence_length
944
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15677451}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:O75185}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:23840669}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 105..125; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 230..250; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 292..312; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 330..350; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 749..769; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 803..823; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 836..853; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 873..893; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 904..924; /note="Helical; Name=10"; /evidence="ECO:0000255
uniprot
proteins