Nanos2
entrez
378430
canonical
uniprot
P60322
canonical
ensembl
ENSMUSG00000051965
resolver
ensp
ENSMUSP00000069765
resolver
enst
ENSMUST00000063563
resolver
genesymbol
Nanos2
resolver
genesymbol_syn
Nos2
resolver
uniprot
F8VQ09
resolver
uniprot
I6ZHM2
resolver
uniprot_entry
I6ZHM2_MOUSE
resolver
uniprot_entry
NANO2_MOUSE
resolver
uniprot_sec
F8VQ09
resolver
amino_acid_sequence
MDLPPFDMWRDYFNLSQVVMDIIQSRKQRQEGEVAEEPNSRPQEKSEQDLEGYPGCLPTICNFCKHNGESRHVYTSHQLKTPEGVVVCPILRHYVCPLCGATGDQAHTLKYCPLNSSQQSLYRRSGRNSAGRRVKR
uniprot
proteins
function
FUNCTION: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state. {ECO:0000269|PubMed:12947200, ECO:0000269|PubMed:17138666, ECO:0000269|PubMed:18281459, ECO:0000269|PubMed:19745153, ECO:0000269|PubMed:20133598}.
uniprot
proteins
mass_dalton
15597
uniprot
proteins
protein_family
Nanos family
uniprot
proteins
pubmed
12947200
uniprot
proteins
pubmed
17138666
uniprot
proteins
pubmed
18281459
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19745153
uniprot
proteins
pubmed
20133598
uniprot
proteins
sequence_length
136
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20133598}. Cytoplasm, P-body {ECO:0000269|PubMed:20133598}. Cytoplasm, perinuclear region {ECO:0000250}. Note=More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis (By similarity). Localizes at P-bodies during gonocyte development. {ECO:0000250}.
uniprot
proteins