STXBP5L
entrez
9515
canonical
uniprot
Q9Y2K9
canonical
ensembl
ENSG00000145087
resolver
ensp
ENSP00000273666
resolver
ensp
ENSP00000420019
resolver
ensp
ENSP00000516710
resolver
ensp
ENSP00000549263
resolver
ensp
ENSP00000608528
resolver
ensp
ENSP00000790471
resolver
enst
ENST00000471454
resolver
enst
ENST00000879204
resolver
enst
ENST00000938469
resolver
genesymbol
STXBP5L
resolver
genesymbol_syn
KIAA1006
resolver
genesymbol_syn
LLGL4
resolver
hgnc
HGNC:30757
resolver
uniprot
B4DKF6
resolver
uniprot
E9PFI2
resolver
uniprot
Q4G1B4
resolver
uniprot
Q6PIC3
resolver
uniprot_entry
B4DKF6_HUMAN
resolver
uniprot_entry
E9PFI2_HUMAN
resolver
uniprot_entry
STB5L_HUMAN
resolver
uniprot_sec
Q4G1B4
resolver
uniprot_sec
Q6PIC3
resolver
amino_acid_sequence
MKKFNFRKVLDGLTASSPGSGSSSGSNSGGGAGSGSVHPAGTAGVLREEIQETLTSEYFQICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKSKRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLKSPSRPFQTTIPHGKSQREGRKSESCKPILKVEYKTCKNSEPFIIFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYFADCPPDLILVLYSIGVKHKKQGYSNKEWPISGGAWNLGAQTYPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVFEKQKVGEGKQTCEIVEEDPFAIQMIYWCPESRIFCVSGVSAYVIIYKFSRHEITTEIVSLEVRLQYDVEDIITPEPETSPPFPDLSAQLPSSRSLSGSTNTVASEGVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQKTVLLSMGTIDLYRSSDLYQRQPRSPRKNKQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKVNRWGPGRPPFRKAQSAACMEISLPVTTEENRENSYNRSRSSSISSIDKDSKEAITALYFMDSFARKNDSTISPCLFVGTSLGMVLIISLNLPLADEQRFTEPVMVLPSGTFLSLKGAVLTFSCMDRMGGLMQPPYEVWRDPNNIDENEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQAKVFSLPSQTCLYVHNITETSFILQANVVVMCSSACLACFCANGHIMIMSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDNLQDMLGDLFTPIETPEAQNRGFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPGPGSIEGMKGAAGGVMGELTRARIALDERGQRLGELEEKTAGMMTSAEAFSKHAHELMLKYKDKKWYQF
uniprot
proteins
function
FUNCTION: Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (By similarity). Promotes as well axonal outgrowth (PubMed:25504045). {ECO:0000250|UniProtKB:Q5DQR4, ECO:0000269|PubMed:25504045}.
uniprot
proteins
mass_dalton
131887
uniprot
proteins
post_translational_modification
PTM: Phosphorylated, leading to STXBP5L increased turnover and subsequent de-repression of insulin secretion (By similarity). Phosphorylated on serine residues in response to glucose or phorbol esters (By similarity). {ECO:0000250|UniProtKB:Q5DQR4}.; PTM: Ubiquitinated by the E3 ligase SYVN1, leading to STXBP5L proteasomal degradation. {ECO:0000250|UniProtKB:Q5DQR4}.
uniprot
proteins
protein_family
WD repeat L(2)GL family
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
14767561
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25504045
uniprot
proteins
sequence_length
1186
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. {ECO:0000305}.
uniprot
proteins