Grid2
entrez
79220
canonical
uniprot
Q63226
canonical
ensembl
ENSRNOG00000006174
resolver
ensembl
ENSRNOG00055014357
resolver
ensembl
ENSRNOG00060021425
resolver
ensembl
ENSRNOG00065029714
resolver
ensp
ENSRNOP00000084985
resolver
ensp
ENSRNOP00000096742
resolver
ensp
ENSRNOP00055020146
resolver
ensp
ENSRNOP00060030808
resolver
ensp
ENSRNOP00065042330
resolver
enst
ENSRNOT00000111210
resolver
enst
ENSRNOT00000116787
resolver
enst
ENSRNOT00055024663
resolver
enst
ENSRNOT00060037360
resolver
enst
ENSRNOT00065051397
resolver
genesymbol
Grid2
resolver
uniprot
A0A8I6AR77
resolver
uniprot
Q62641
resolver
uniprot_entry
A0A8I6AR77_RAT
resolver
uniprot_entry
GRID2_RAT
resolver
uniprot_sec
Q62641
resolver
activity_regulation
ACTIVITY REGULATION: Activated by the binding of D-serine or GABA (gamma-aminobutyric acid), which results in the asymmetric opening of the ion channel for conductance (By similarity). Its ligand-gated cation channel activity was previously disputed due to a lack of evidence for direct ligand-gated ion channel activity (By similarity). {ECO:0000250|UniProtKB:O43424}.
uniprot
proteins
amino_acid_sequence
MEVFPLLFFLSFWWSRTWDLATSDSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLETWWSRRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGSVPEHRTGPFRHRAPNGGFFRSPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI
uniprot
proteins
function
FUNCTION: Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system (By similarity). Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand (By similarity). Promotes synaptogenesis and mediates the D-serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex (By similarity). In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine (By similarity). Cation-selective ion channel activity can be triggered by GRM1 in Purkinje cells (By similarity). {ECO:0000250|UniProtKB:O43424, ECO:0000250|UniProtKB:Q61625}.
uniprot
proteins
mass_dalton
113259
uniprot
proteins
mutagenesis
MUTAGEN 945; /note="S->A: No effect."; /evidence="ECO:0000269|PubMed:14572453"; MUTAGEN 952; /note="F->A: Loss of interaction with AP4M1."; /evidence="ECO:0000269|PubMed:14572453"; MUTAGEN 954; /note="F->A: Loss of interaction with AP4M1."; /evidence="ECO:0000269|PubMed:14572453"; MUTAGEN 957; /note="V->E: Loss of interaction with AP4M1."; /evidence="ECO:0000269|PubMed:14572453"; MUTAGEN 965..966; /note="FR->AA: Loss of interaction with AP4M1."; /evidence="ECO:0000269|PubMed:14572453"; MUTAGEN 975..976; /note="FR->AA: Loss of interaction with AP4M1."; /evidence="ECO:0000269|PubMed:14572453
uniprot
proteins
protein_family
GRID2 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
11829466
uniprot
proteins
pubmed
12589829
uniprot
proteins
pubmed
14572453
uniprot
proteins
pubmed
17715062
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8422924
uniprot
proteins
sequence_length
1007
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q61625}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O43424}.
uniprot
proteins
transmembrane_region
TRANSMEM 567..587; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:O43424"; TRANSMEM 625..653; /note="Helical; Name=M3"; /evidence="ECO:0000250|UniProtKB:O43424"; TRANSMEM 831..851; /note="Helical; Name=M4"; /evidence="ECO:0000250|UniProtKB:O43424
uniprot
proteins