H1-6
entrez
3010
canonical
uniprot
P22492
canonical
ensembl
ENSG00000187475
resolver
ensp
ENSP00000341214
resolver
enst
ENST00000338379
resolver
genesymbol
H1-6
resolver
genesymbol_syn
H1FT
resolver
genesymbol_syn
H1T
resolver
genesymbol_syn
HIST1H1T
resolver
hgnc
HGNC:4720
resolver
uniprot
Q6ISI1
resolver
uniprot
Q8IUE8
resolver
uniprot_entry
H1T_HUMAN
resolver
uniprot_sec
Q6ISI1
resolver
uniprot_sec
Q8IUE8
resolver
amino_acid_sequence
MSETVPAASASAGVAAMEKLPTKKRGRKPAGLISASRKVPNLSVSKLITEALSVSQERVGMSLVALKKALAAAGYDVEKNNSRIKLSLKSLVNKGILVQTRGTGASGSFKLSKKVIPKSTRSKAKKSVSAKTKKLVLSRDSKSPKTAKTNKRAKKPRATTPKTVRSGRKAKGAKGKQQQKSPVKARASKSKLTQHHEVNVRKATSKK
uniprot
proteins
function
FUNCTION: Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable). {ECO:0000269|PubMed:26757249, ECO:0000305}.
uniprot
proteins
mass_dalton
22019
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in early spermatids. {ECO:0000250|UniProtKB:P06349}.; PTM: Citrullination at Arg-58 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. {ECO:0000250|UniProtKB:P43275}.; PTM: Deamidation of Asn-80 and Asn-81 by CTPS1 in response to DNA damage promotes subsequent acetylation of histone H1 at Lys-79 (H1K75ac). {ECO:0000250|UniProtKB:P10412}.; PTM: Acetylated at Lys-79 (H1K75ac) by EP300 following deamidation of Asn-80 and Asn-81 by CTPS1 in response to DNA damage, thereby increasing chromatin accessibility to facilitate the recruitment of DNA repair proteins. {ECO:0000250|UniProtKB:P10412}.
uniprot
proteins
protein_family
Histone H1/H5 family
uniprot
proteins
pubmed
12408966
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1889752
uniprot
proteins
pubmed
26757249
uniprot
proteins
pubmed
8175896
uniprot
proteins
sequence_length
207
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
uniprot
proteins