Peg10
entrez
170676
canonical
uniprot
Q7TN75
canonical
ensembl
ENSMUSG00000092035
resolver
ensp
ENSMUSP00000134963
resolver
genesymbol
Peg10
resolver
genesymbol_syn
Edr
resolver
genesymbol_syn
Mar2
resolver
genesymbol_syn
Mart2
resolver
genesymbol_syn
Mef3l1
resolver
genesymbol_syn
Rgag3
resolver
uniprot
Q9EQ11
resolver
uniprot_entry
PEG10_MOUSE
resolver
uniprot_sec
Q9EQ11
resolver
amino_acid_sequence
MAAAGGSSNCPPPPPPPPPNNNNNNNTPKSPGVPDAEDDDERRHDELPEDINNFDEDMNRQFENMNLLDQVELLAQSYSLLDHLDDFDDDDEDDDFDPEPDQDELPEYSDDDDLELQGAAAAPIPNFFSDDDCLEDLPEKFDGNPDMLGPFMYQCQLFMEKSTRDFSVDRIRVCFVTSMLIGRAARWATAKLQRCTYLMHNYTAFMMELKHVFEDPQRREAAKRKIRRLRQGPGPVVDYSNAFQMIAQDLDWTEPALMDQFQEGLNPDIRAELSRQEAPKTLAALITACIHIERRLARDAAAKPDPSPRALVMPPNSQTDPTEPVGGARMRLSKEEKERRRKMNLCLYCGNGGHFADTCPAKASKNSPPGKLPGPAVGGPSATGPERIRSPPSEASTQHLQVMLQIHMPGRPTLFVRAMIDSGASGNFIDQDFVIQNAIPLRIKDWPVMVEAIDGHPIASGPIILETHHLIVDLGDHREILSFDVTQSPFFPIVLGIRWLSTHDPHITWSTRSIVFNSDYCRLRCRMFAQIPSNLLFTVPQPNLHPYLLHHVHPHVHPHMHQHLHQHLHQFLHPDPHQYPHPDPHYHHHQQADMQHQLQQYLYQYLYYHLYPVMHHHLPPDQHEHLHEYLHQYLHQYLHQFLHHHLHPDLHQYLYQYLHNHMNPDPHHHPHPDPPQDPHHPPHQDPHQHPDPHQDPPHQDPHQDAHQDPHMDPHLHQHQHPQPQPHPQQHPNHPQQPPFFYHMAGFRIYHPVRYYYIQNVYTPVDEHVYPGHRVVDPNIEMIPGAHSLPSGHLYSMSESEMNALRNFVDRNVKDGLMTPTVAPNGAQVLQVKRGWKLQVTYNCRAPQSGTIQNQYLRMSLPNMGDPAHLASYGEFVQVPGYPYPAYVYYTSPHMMTAWYPVGRDVHGRIIVVPVVITWSQNTNRQPPVPQYPPPQPPPPPPPPPPPPPPPPASSCSAA
uniprot
proteins
function
FUNCTION: Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:30951545, PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (PubMed:16341224, PubMed:30951545). Involved at the immediate early stage of adipocyte differentiation (PubMed:17707377). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (By similarity). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidence is however required to confirm this result (PubMed:9473521). {ECO:0000250|UniProtKB:Q86TG7, ECO:0000269|PubMed:16341224, ECO:0000269|PubMed:17707377, ECO:0000269|PubMed:30951545, ECO:0000269|PubMed:34413232, ECO:0000269|PubMed:9473521}.
uniprot
proteins
mass_dalton
109849
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated (PubMed:30951545). Deubiquitinated at Lys-362 and Lys-365 by USP9X (PubMed:30951545). {ECO:0000269|PubMed:30951545}.; PTM: [Isoform 1]: Undergoes proteolytic cleavage. {ECO:0000250|UniProtKB:Q86TG7}.
uniprot
proteins
pubmed
11158386
uniprot
proteins
pubmed
11574691
uniprot
proteins
pubmed
12840045
uniprot
proteins
pubmed
16341224
uniprot
proteins
pubmed
16423995
uniprot
proteins
pubmed
17707377
uniprot
proteins
pubmed
17942406
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
25888968
uniprot
proteins
pubmed
30951545
uniprot
proteins
pubmed
34413232
uniprot
proteins
pubmed
9473521
uniprot
proteins
sequence_length
958
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Extracellular vesicle membrane {ECO:0000269|PubMed:30951545, ECO:0000269|PubMed:34413232}. Cytoplasm {ECO:0000269|PubMed:30951545}. Nucleus {ECO:0000250|UniProtKB:Q86TG7}. Note=Forms virion-like extracellular vesicles that are released from cells. {ECO:0000269|PubMed:30951545, ECO:0000269|PubMed:34413232}.
uniprot
proteins