MED25
entrez
81857
canonical
uniprot
Q71SY5
canonical
ensembl
ENSG00000104973
resolver
ensp
ENSP00000326767
resolver
ensp
ENSP00000470692
resolver
enst
ENST00000593767
resolver
genesymbol
MED25
resolver
genesymbol_syn
ACID1
resolver
genesymbol_syn
ARC92
resolver
genesymbol_syn
PTOV2
resolver
hgnc
HGNC:28845
resolver
uniprot
A8K095
resolver
uniprot
B9TX30
resolver
uniprot
M0QZQ2
resolver
uniprot
O95783
resolver
uniprot
Q6P143
resolver
uniprot
Q6QMH5
resolver
uniprot
Q707U4
resolver
uniprot
Q8TB55
resolver
uniprot
Q9H0L5
resolver
uniprot
Q9HB34
resolver
uniprot_entry
M0QZQ2_HUMAN
resolver
uniprot_entry
MED25_HUMAN
resolver
uniprot_sec
A8K095
resolver
uniprot_sec
B9TX30
resolver
uniprot_sec
O95783
resolver
uniprot_sec
Q6P143
resolver
uniprot_sec
Q6QMH5
resolver
uniprot_sec
Q707U4
resolver
uniprot_sec
Q8TB55
resolver
uniprot_sec
Q9H0L5
resolver
uniprot_sec
Q9HB34
resolver
amino_acid_sequence
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
uniprot
proteins
disease_involvement
DISEASE: Charcot-Marie-Tooth disease, axonal, type 2B2 (CMT2B2) [MIM:605589]: A recessive axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. {ECO:0000269|PubMed:19290556}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Basel-Vanagaite-Smirin-Yosef syndrome (BVSYS) [MIM:616449]: An autosomal recessive syndrome characterized by eye, brain, cardiac and palatal abnormalities as well as growth retardation, microcephaly and severe intellectual disability. {ECO:0000269|PubMed:25792360}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription. {ECO:0000269|PubMed:14657022, ECO:0000269|PubMed:14983011, ECO:0000269|PubMed:17641689}.
uniprot
proteins
mass_dalton
78171
uniprot
proteins
mutagenesis
MUTAGEN 646; /note="L->A: Abrogates interaction with RARA."; /evidence="ECO:0000269|PubMed:17641689"; MUTAGEN 649..650; /note="LL->AA: Abrogates interaction with RARA."; /evidence="ECO:0000269|PubMed:17641689
uniprot
proteins
protein_family
Mediator complex subunit 25 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12163014
uniprot
proteins
pubmed
14657022
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14983011
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15175163
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15989967
uniprot
proteins
pubmed
17641689
uniprot
proteins
pubmed
19290556
uniprot
proteins
pubmed
20974256
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25527630
uniprot
proteins
pubmed
25792360
uniprot
proteins
sequence_length
747
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14657022}.
uniprot
proteins