Ndc80
entrez
67052
canonical
uniprot
Q9D0F1
canonical
ensembl
ENSMUSG00000024056
resolver
ensp
ENSMUSP00000024851
resolver
enst
ENSMUST00000024851
resolver
genesymbol
Ndc80
resolver
genesymbol_syn
Hec1
resolver
genesymbol_syn
Kntc2
resolver
uniprot
Q3TQT6
resolver
uniprot
Q3UWM5
resolver
uniprot
Q99P70
resolver
uniprot_entry
NDC80_MOUSE
resolver
uniprot_sec
Q3TQT6
resolver
uniprot_sec
Q3UWM5
resolver
uniprot_sec
Q99P70
resolver
amino_acid_sequence
MKRSSVSTCGAGRLSMQELRTLDLNKPGLYTPQTKERSTFGKLSTHKPTSERKVSIFGKRTSGHGSRNSQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLYEFLTENGYVYSVSMKSLQAPSTKEFLKIFAFLYGFLCPSYELPGTKCEEEVPRIFKALGYPFTLSKSSMYTVGAPHTWPHIVAALVWLIDCIKIDTAMKESSPLFDDGQLWGEETEDGIKHNKLFLEYTKKCYEKFMTGADSFEEEDAELQAKLKDLYKVDASKLESLEAENKALNEQIARLEEEREREPNRLMSLKKLKASLQADVQNYKAYMSNLESHLAVLKQKSNSLDEEIGRVEQECETVKQENTRLQSIVDNQKYSVADIERINHEKNELQQTINKLTKDLEAEQQQMWNEELKYARGKEAIEAQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRTQVYAPLKELLNESEEEINKALNKKRHLEDTLEQLNTMKTESKNTVRMLKEEIQKLDDLHQQAVKEAEEKDKKSASELESLEKHKHLLESGVNDGLSEAMDELDAVQREYQLTVKTTTEERRKVENNLQRLLEMVATHVGSLEKHLEEENAKADREYEEFMSEDLLENIREMAEKYKRNAAQLKAPDK
uniprot
proteins
function
FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules. {ECO:0000250|UniProtKB:O14777}.
uniprot
proteins
mass_dalton
73962
uniprot
proteins
post_translational_modification
PTM: Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. Also phosphorylated by AURKA and AURKB. {ECO:0000250|UniProtKB:O14777}.; PTM: Acetylated at Lys-53 and Lys-59 by KAT5 during mitosis, promoting robust kinetochore-microtubule attachment. Deacetylated by SIRT1. {ECO:0000250|UniProtKB:O14777}.
uniprot
proteins
protein_family
NDC80/HEC1 family
uniprot
proteins
pubmed
11266451
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9315664
uniprot
proteins
sequence_length
642
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O14777}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:O14777}. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. {ECO:0000250|UniProtKB:O14777}.
uniprot
proteins