NASP
entrez
4678
canonical
uniprot
P49321
canonical
ensembl
ENSG00000132780
resolver
ensp
ENSP00000255120
resolver
ensp
ENSP00000255121
resolver
ensp
ENSP00000438871
resolver
ensp
ENSP00000594027
resolver
ensp
ENSP00000594040
resolver
genesymbol
NASP
resolver
hgnc
HGNC:7644
resolver
uniprot
A8K6H2
resolver
uniprot
B4DQP3
resolver
uniprot
D3DQ07
resolver
uniprot
F5H3J2
resolver
uniprot
Q53GW5
resolver
uniprot
Q5T622
resolver
uniprot
Q5T625
resolver
uniprot
Q5T626
resolver
uniprot
Q96A69
resolver
uniprot
Q9BTW2
resolver
uniprot_entry
NASP_HUMAN
resolver
uniprot_entry
Q5T626_HUMAN
resolver
uniprot_sec
A8K6H2
resolver
uniprot_sec
B4DQP3
resolver
uniprot_sec
D3DQ07
resolver
uniprot_sec
F5H3J2
resolver
uniprot_sec
Q53GW5
resolver
uniprot_sec
Q5T622
resolver
uniprot_sec
Q5T625
resolver
uniprot_sec
Q96A69
resolver
uniprot_sec
Q9BTW2
resolver
amino_acid_sequence
MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC
uniprot
proteins
function
FUNCTION: Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.
uniprot
proteins
mass_dalton
85238
uniprot
proteins
protein_family
NASP family
uniprot
proteins
pubmed
1426632
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22195965
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
27618665
uniprot
proteins
pubmed
33857403
uniprot
proteins
pubmed
8724350
uniprot
proteins
sequence_length
788
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99MD9}. Nucleus {ECO:0000250|UniProtKB:Q99MD9}.
uniprot
proteins