Ascl5
entrez
226439
canonical
uniprot
M0QWB7
canonical
ensembl
ENSMUSG00000097918
resolver
ensp
ENSMUSP00000137746
resolver
enst
ENSMUST00000180436
resolver
genesymbol
Ascl5
resolver
genesymbol_syn
AmeloD
resolver
genesymbol_syn
bHLHa47
resolver
uniprot_entry
ASCL5_MOUSE
resolver
amino_acid_sequence
MNSNFCRALVDRGPPGGMQLGVVAPAGQTPLAATEPLSNVPFLLYPGHSEPPYYDAYTGVFPYVPFPGAFGVYDYPFEPAFIQKRNERERQRVKCVNEGYARLRGHLPGALTEKRLSKVETLRAAIRYIKYLQELLSATPDGAPPPATSPPPAHTGHSNVPQPSSLVAESSGSPFSSSPFLESEEPSL
uniprot
proteins
function
FUNCTION: Transcription factor (PubMed:30426815). Probably binds E-box motifs 5'-CANNTG-3' in complex with transcription factor TCF3/E12 (PubMed:30426815). Negatively modulates transcription of target genes such as CDH1/E-cadherin, perhaps by recruiting the PRC2 repressive complex to regulatory elements (PubMed:30426815, PubMed:30504223). Regulates ameloblast development and tooth germ growth, perhaps acting by positively modulating migration of inner enamel epithelium (IEE) cells (PubMed:30426815, PubMed:30504223, PubMed:34812512). Plays a role in enamel formation (PubMed:34812512). {ECO:0000269|PubMed:30426815, ECO:0000269|PubMed:30504223, ECO:0000269|PubMed:34812512}.
uniprot
proteins
mass_dalton
20371
uniprot
proteins
mutagenesis
MUTAGEN 89; /note="E->K: Heterozygous mutant mice have dental anomalies resembling lobodontia. Homozygous mutant mice display severe defects in tooth and jaw development."; /evidence="ECO:0000269|PubMed:41673016
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
30426815
uniprot
proteins
pubmed
30504223
uniprot
proteins
pubmed
34812512
uniprot
proteins
pubmed
41673016
uniprot
proteins
sequence_length
188
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
uniprot
proteins