Camk1d
entrez
227541
canonical
uniprot
Q8BW96
canonical
ensembl
ENSMUSG00000039145
resolver
ensp
ENSMUSP00000037028
resolver
ensp
ENSMUSP00000110638
resolver
ensp
ENSMUSP00000202111
resolver
ensp
ENSMUSP00000202112
resolver
genesymbol
Camk1d
resolver
uniprot
B1AW58
resolver
uniprot
Q3TDM2
resolver
uniprot
Q3U450
resolver
uniprot
Q3UH04
resolver
uniprot
Q80W64
resolver
uniprot
Q8BWI7
resolver
uniprot_entry
B1AW58_MOUSE
resolver
uniprot_entry
KCC1D_MOUSE
resolver
uniprot_entry
Q3TDM2_MOUSE
resolver
uniprot_entry
Q3UH04_MOUSE
resolver
uniprot_sec
Q3U450
resolver
uniprot_sec
Q80W64
resolver
uniprot_sec
Q8BWI7
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-180 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-180 results in several fold increase in total activity. Unlike CaMK4, may be unable to exhibit autonomous activity after Ca(2+)/calmodulin activation (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALSKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRRLQLGSSLDSSNASVSSNLSLASQKDCLAPSTLCSFLSSSSGVAGVGAERRPRPTTVTTGHTGSK
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta (By similarity). Isoform 1 but not isoform 2 activates CREB1. {ECO:0000250, ECO:0000269|PubMed:14980499, ECO:0000269|PubMed:18400360}.
uniprot
proteins
mass_dalton
42919
uniprot
proteins
mutagenesis
MUTAGEN 52; /note="K->D: Catalytically inactive form."; MUTAGEN 289..292; /note="IHES->DEDD: Constitutively active form; when associated with A-301."; /evidence="ECO:0000269|PubMed:18400360"; MUTAGEN 301; /note="F->A: Constitutively active form; when associated with 289-A--A-292."; /evidence="ECO:0000269|PubMed:18400360
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
12897189
uniprot
proteins
pubmed
14980499
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18400360
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Nuclear upon activation. {ECO:0000250}.
uniprot
proteins