Tbrg1
entrez
300521
canonical
uniprot
Q5PQK8
canonical
ensembl
ENSRNOG00000023850
resolver
ensp
ENSRNOP00000037323
resolver
enst
ENSRNOT00000039729
resolver
genesymbol
Tbrg1
resolver
uniprot_entry
TBRG1_RAT
resolver
amino_acid_sequence
MSVLSGLASEPRTPLSSKARMKRLPKKNQNEKYRLKYLRLRRAAKATVFENAAVCDEIARLEEKFLKAKEERRYLLKKLLQIHALTEGEPQAAAPSHSSSLPLAYGVTSSVGTIQGAGPSTGAEEPFAKKSKKEKKEKGKENSKLEVLKKTSKRKKMEGGARKLVRPIALDPSGQPVFPIGLGGLTVYSLGEIITNRPGFHDENAIYPVGYCSTRVYASMKCPDQKCLYTCQIKDGGVQPQFEIVPEDDPRNTIVGSSADACYEELLRAISAATGKLMPNPLSCGADFFGFSHPTIHNLIQSCPEAQNCVNYQWVKFDACKPRKGQLSQELPENDAAMSLEAFPTQTFDDDHEDSILPGSLDLPELQHEAFVSSYQPEFLTHEPLVDTDLQHLKSPSQCSPIQSSD
uniprot
proteins
function
FUNCTION: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
44785
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation. {ECO:0000250}.
uniprot
proteins
protein_family
TBRG1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins