LPCAT4
entrez
254531
canonical
uniprot
Q643R3
canonical
ensembl
ENSG00000176454
resolver
ensembl
ENSG00000291994
resolver
ensp
ENSP00000317300
resolver
ensp
ENSP00000517730
resolver
ensp
ENSP00000723533
resolver
ensp
ENSP00000732264
resolver
enst
ENST00000314891
resolver
enst
ENST00000709501
resolver
genesymbol
LPCAT4
resolver
genesymbol_syn
AGPAT7
resolver
genesymbol_syn
AYTL3
resolver
genesymbol_syn
LPEAT2
resolver
hgnc
HGNC:30059
resolver
uniprot
A8K2K8
resolver
uniprot
O43412
resolver
uniprot
Q7Z4P4
resolver
uniprot
Q8IUL7
resolver
uniprot
Q8TB38
resolver
uniprot_entry
LPCT4_HUMAN
resolver
uniprot_sec
A8K2K8
resolver
uniprot_sec
O43412
resolver
uniprot_sec
Q7Z4P4
resolver
uniprot_sec
Q8IUL7
resolver
uniprot_sec
Q8TB38
resolver
amino_acid_sequence
MSQGSPGDWAPLDPTPGPPASPNPFVHELHLSRLQRVKFCLLGALLAPIRVLLAFIVLFLLWPFAWLQVAGLSEEQLQEPITGWRKTVCHNGVLGLSRLLFFLLGFLRIRVRGQRASRLQAPVLVAAPHSTFFDPIVLLPCDLPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEVRRRATSGGKWPQVLFFPEGTCSNKKALLKFKPGAFIAGVPVQPVLIRYPNSLDTTSWAWRGPGVLKVLWLTASQPCSIVDVEFLPVYHPSPEESRDPTLYANNVQRVMAQALGIPATECEFVGSLPVIVVGRLKVALEPQLWELGKVLRKAGLSAGYVDAGAEPGRSRMISQEEFARQLQLSDPQTVAGAFGYFQQDTKGLVDFRDVALALAALDGGRSLEELTRLAFELFAEEQAEGPNRLLYKDGFSTILHLLLGSPHPAATALHAELCQAGSSQGLSLCQFQNFSLHDPLYGKLFSTYLRPPHTSRGTSQTPNASSPGNPTALANGTVQAPKQKGD
uniprot
proteins
ec_number
2.3.1.121
uniprot
proteins
ec_number
2.3.1.23
uniprot
proteins
ec_number
2.3.1.63
uniprot
proteins
ec_number
2.3.1.n6
uniprot
proteins
ec_number
2.3.1.n7
uniprot
proteins
function
FUNCTION: Acyl-CoA-dependent lysophospholipid acyltransferase involved in phospholipid remodeling. Displays acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively (PubMed:18458083, PubMed:41740885). Can use various medium- and long-chain, saturated and unsaturated fatty acyl-CoAs, displaying the highest activity toward unsaturated fatty acyl-CoAs (PubMed:18458083, PubMed:41740885). Catalysis the biosynthesis of atypical phospholipids carrying unsaturated fatty acids esterified at the sn-1 position of the glycerol backbone. Transfers unsaturated fatty acyl chains to the sn-1 position of lysophosphatidylcholines, lysophosphatidylethanolamines and lysophosphatidylserines with lysophosphatidylcholines being the preferred substrates. Contributes to the remodeling of brain phosphatidylcholine species with unsaturated fatty acyl chains such as C18:1, C18:2, C20:4 and C22:6 at the sn-1 position (PubMed:41740885). Has no apparent acyltransferase activity toward lysophosphatidylinositols, lysophosphatidic acids, lysophosphatidylglycerols, glycerol-3-phosphates or diacylglycerols. Has no acetyltransferase activity toward lysoplatelet-activating factor (lyso-PAF) (PubMed:18458083, PubMed:41740885). {ECO:0000269|PubMed:18458083, ECO:0000269|PubMed:41740885}.
uniprot
proteins
mass_dalton
57219
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000269|PubMed:41740885}.
uniprot
proteins
protein_family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16243729
uniprot
proteins
pubmed
18458083
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
41740885
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16243729, ECO:0000269|PubMed:18458083}; Multi-pass membrane protein {ECO:0000269|PubMed:16243729, ECO:0000269|PubMed:18458083}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..62; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins