MRC2
entrez
9902
canonical
uniprot
Q9UBG0
canonical
ensembl
ENSG00000011028
resolver
ensp
ENSP00000307513
resolver
ensp
ENSP00000694457
resolver
enst
ENST00000303375
resolver
genesymbol
MRC2
resolver
genesymbol_syn
CLEC13E
resolver
genesymbol_syn
ENDO180
resolver
genesymbol_syn
KIAA0709
resolver
genesymbol_syn
UPARAP
resolver
hgnc
HGNC:16875
resolver
uniprot
A6H8K4
resolver
uniprot
D3DU08
resolver
uniprot
Q7LGE7
resolver
uniprot
Q9Y5P9
resolver
uniprot_entry
MRC2_HUMAN
resolver
uniprot_sec
A6H8K4
resolver
uniprot_sec
D3DU08
resolver
uniprot_sec
Q7LGE7
resolver
uniprot_sec
Q9Y5P9
resolver
amino_acid_sequence
MGPGRPAPAPWPRHLLRCVLLLGCLHLGRPGAPGDAALPEPNVFLIFSHGLQGCLEAQGGQVRVTPACNTSLPAQRWKWVSRNRLFNLGTMQCLGTGWPGTNTTASLGMYECDREALNLRWHCRTLGDQLSLLLGARTSNISKPGTLERGDQTRSGQWRIYGSEEDLCALPYHEVYTIQGNSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWDKDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITEIHEQTYINGLLTGYSSTLWIGLNDLDTSGGWQWSDNSPLKYLNWESDQPDNPSEENCGVIRTESSGGWQNRDCSIALPYVCKKKPNATAEPTPPDRWANVKVECEPSWQPFQGHCYRLQAEKRSWQESKKACLRGGGDLVSIHSMAELEFITKQIKQEVEELWIGLNDLKLQMNFEWSDGSLVSFTHWHPFEPNNFRDSLEDCVTIWGPEGRWNDSPCNQSLPSICKKAGQLSQGAAEEDHGCRKGWTWHSPSCYWLGEDQVTYSEARRLCTDHGSQLVTITNRFEQAFVSSLIYNWEGEYFWTALQDLNSTGSFFWLSGDEVMYTHWNRDQPGYSRGGCVALATGSAMGLWEVKNCTSFRARYICRQSLGTPVTPELPGPDPTPSLTGSCPQGWASDTKLRYCYKVFSSERLQDKKSWVQAQGACQELGAQLLSLASYEEEHFVANMLNKIFGESEPEIHEQHWFWIGLNRRDPRGGQSWRWSDGVGFSYHNFDRSRHDDDDIRGCAVLDLASLQWVAMQCDTQLDWICKIPRGTDVREPDDSPQGRREWLRFQEAEYKFFEHHSTWAQAQRICTWFQAELTSVHSQAELDFLSHNLQKFSRAQEQHWWIGLHTSESDGRFRWTDGSIINFISWAPGKPRPVGKDKKCVYMTASREDWGDQRCLTALPYICKRSNVTKETQPPDLPTTALGGCPSDWIQFLNKCFQVQGQEPQSRVKWSEAQFSCEQQEAQLVTITNPLEQAFITASLPNVTFDLWIGLHASQRDFQWVEQEPLMYANWAPGEPSGPSPAPSGNKPTSCAVVLHSPSAHFTGRWDDRSCTEETHGFICQKGTDPSLSPSPAALPPAPGTELSYLNGTFRLLQKPLRWHDALLLCESRNASLAYVPDPYTQAFLTQAARGLRTPLWIGLAGEEGSRRYSWVSEEPLNYVGWQDGEPQQPGGCTYVDVDGAWRTTSCDTKLQGAVCGVSSGPPPPRRISYHGSCPQGLADSAWIPFREHCYSFHMELLLGHKEARQRCQRAGGAVLSILDEMENVFVWEHLQSYEGQSRGAWLGMNFNPKGGTLVWQDNTAVNYSNWGPPGLGPSMLSHNSCYWIQSNSGLWRPGACTNITMGVVCKLPRAEQSSFSPSALPENPAALVVVLMAVLLLLALLTAALILYRRRQSIERGAFEGARYSRSSSSPTEATEKNILVSDMEMNEQQE
uniprot
proteins
function
FUNCTION: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). {ECO:0000269|PubMed:10683150, ECO:0000269|PubMed:12972549}.
uniprot
proteins
mass_dalton
166674
uniprot
proteins
mutagenesis
MUTAGEN 472; /note="N->D: Reduced sugar-binding activity."; /evidence="ECO:0000269|PubMed:12399458"; MUTAGEN 1452; /note="Y->A: No alteration of distribution and trafficking."; /evidence="ECO:0000269|PubMed:12068012"; MUTAGEN 1464; /note="E->A: Increased cell surface distribution."; /evidence="ECO:0000269|PubMed:12068012"; MUTAGEN 1468..1469; /note="LV->AA: Reduction of endocytotic activity; distribution almost restricted to the cell surface."; /evidence="ECO:0000269|PubMed:12068012
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10683150, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218}.
uniprot
proteins
pubmed
10636902
uniprot
proteins
pubmed
10683150
uniprot
proteins
pubmed
12068012
uniprot
proteins
pubmed
12399458
uniprot
proteins
pubmed
12972549
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
20388717
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
8702911
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
1479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 1415..1435; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins