Spsb4
entrez
211949
canonical
uniprot
Q8R5B6
canonical
ensembl
ENSMUSG00000046997
resolver
ensp
ENSMUSP00000057849
resolver
genesymbol
Spsb4
resolver
genesymbol_syn
Ssb4
resolver
uniprot
Q8BJI9
resolver
uniprot
Q8VHS8
resolver
uniprot_entry
SPSB4_MOUSE
resolver
uniprot_sec
Q8BJI9
resolver
uniprot_sec
Q8VHS8
resolver
amino_acid_sequence
MGQKLSGSLKSVEVREPALRPAKRELRGLEPGRPARLDQLLDMPAAGLAVQLRHAWNPEDRSLNVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQIHWPARQRGTHAVVGVATARAPLHSVGYTALVGSDSESWGWDLGRSRLYHDGKNRPGVAYPAFLGPDEAFALPDSLLVVLDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCRRSIRSALGRQRLRDIGSLPLPQSLKNYLQYQ
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of the EphB2/CTF2 (By similarity). Regulates cellular clock function by mediating ubiquitination and proteasomal degradation of the circadian transcriptional repressor NR1D1 (By similarity). {ECO:0000250|UniProtKB:Q96A44}.
uniprot
proteins
mass_dalton
30286
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
SPSB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16369487
uniprot
proteins
pubmed
20561531
uniprot
proteins
pubmed
20603330
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q96A44}. Note=Exhibits a diffuse cytosolic localization. {ECO:0000250|UniProtKB:Q96A44}.
uniprot
proteins