P52191
uniprot
P52191
canonical
activity_regulation
ACTIVITY REGULATION: Channel activity is strongly regulated by variations of cytosolic pH; channels are activated by alkaline and inhibited by acidic pH values (PubMed:20807765). Activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2) (PubMed:18690035). {ECO:0000269|PubMed:18690035, ECO:0000269|PubMed:20807765}.
uniprot
proteins
amino_acid_sequence
MSYYGSSYRIVNVDSKYPGYPPEHAIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYMVDIFTTLVDTKWRHMFVVFSLSYILSWLIFGSIFWLIALHHGDLLSDPDITPCVDNVHSFTAAFLFSLETQTTIGYGYRCVTEECSVAVLTVILQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYSEDSEGRMTMAFKDLKLVNDQIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYVPREILWGHRFHDVLEVKRKYYKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLNNLEKTSPARGSCTSDTNTRRRSFSAVAMVSSCENPEETSLSPQDECKEVPYQKALLTLNRISMESQM
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance (By similarity). In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules. {ECO:0000250, ECO:0000250|UniProtKB:Q9NPI9}.
uniprot
proteins
mass_dalton
47936
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ16 subfamily
uniprot
proteins
pubmed
10764726
uniprot
proteins
pubmed
18690035
uniprot
proteins
pubmed
20807765
uniprot
proteins
pubmed
7874445
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9NPI9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NPI9}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9NPI9}. Note=In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10. {ECO:0000250|UniProtKB:Q9NPI9}.
uniprot
proteins
transmembrane_region
TRANSMEM 68..94; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:F1NHE9"; TRANSMEM 144..171; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:F1NHE9
uniprot
proteins