Nppb
entrez
25105
canonical
uniprot
P13205
canonical
ensembl
ENSRNOG00000008141
resolver
ensembl
ENSRNOG00055022304
resolver
ensembl
ENSRNOG00060026636
resolver
ensembl
ENSRNOG00065011536
resolver
ensp
ENSRNOP00000010778
resolver
ensp
ENSRNOP00055031206
resolver
ensp
ENSRNOP00060038328
resolver
ensp
ENSRNOP00065014333
resolver
enst
ENSRNOT00055038329
resolver
enst
ENSRNOT00060046140
resolver
enst
ENSRNOT00065018755
resolver
genesymbol
Nppb
resolver
uniprot_entry
ANFB_RAT
resolver
amino_acid_sequence
MDLQKVLPQMILLLLFLNLSPLGGHSHPLGSPSQSPEQSTMQKLLELIREKSEEMAQRQLSKDQGPTKELLKRVLRSQDSAFRIQERLRNSKMAHSSSCFGQKIDRIGAVSRLGCDGLRLF
uniprot
proteins
function
FUNCTION: [Brain natriuretic peptide 45]: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed:2525380, PubMed:9252368). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (By similarity). Likely involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, kaluresis and chloruresis (PubMed:2525380, PubMed:9252368). {ECO:0000250|UniProtKB:P40753, ECO:0000269|PubMed:2525380, ECO:0000269|PubMed:9252368}.
uniprot
proteins
mass_dalton
13656
uniprot
proteins
post_translational_modification
PTM: The precursor molecule is proteolytically cleaved by the endoprotease Furin to produce brain natriuretic peptide 45 (PubMed:9252368). May undergo further proteolytic cleavage by various proteases such as DPP4, MME and possibly FAP, to give rise to a variety of shorter peptides (By similarity). May be cleaved at Ser-91 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (By similarity). May be degraded by IDE (By similarity). During IDE degradation, the resulting products initially increase the activation of NPR1 and can also stimulate NPR2 to produce cGMP before the fragments are completely degraded and inactivated by IDE (in vitro) (By similarity). {ECO:0000250|UniProtKB:P16860, ECO:0000269|PubMed:9252368}.
uniprot
proteins
protein_family
Natriuretic peptide family
uniprot
proteins
pubmed
1837590
uniprot
proteins
pubmed
2144113
uniprot
proteins
pubmed
2522776
uniprot
proteins
pubmed
2525379
uniprot
proteins
pubmed
2525380
uniprot
proteins
pubmed
2528349
uniprot
proteins
pubmed
2673236
uniprot
proteins
pubmed
30980393
uniprot
proteins
pubmed
9252368
uniprot
proteins
sequence_length
121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Brain natriuretic peptide 45]: Secreted {ECO:0000269|PubMed:2525379, ECO:0000269|PubMed:2528349}.
uniprot
proteins