Btrc
entrez
12234
canonical
uniprot
Q3ULA2
canonical
ensembl
ENSMUSG00000025217
resolver
ensp
ENSMUSP00000070728
resolver
ensp
ENSMUSP00000107567
resolver
ensp
ENSMUSP00000153562
resolver
ensp
ENSMUSP00000256746
resolver
ensp
ENSMUSP00000256747
resolver
ensp
ENSMUSP00000334510
resolver
ensp
ENSMUSP00000334511
resolver
ensp
ENSMUSP00000334512
resolver
ensp
ENSMUSP00000334514
resolver
ensp
ENSMUSP00000334515
resolver
ensp
ENSMUSP00000334517
resolver
ensp
ENSMUSP00000334520
resolver
ensp
ENSMUSP00000334521
resolver
ensp
ENSMUSP00000334522
resolver
ensp
ENSMUSP00000334523
resolver
ensp
ENSMUSP00000334524
resolver
ensp
ENSMUSP00000334525
resolver
ensp
ENSMUSP00000352245
resolver
ensp
ENSMUSP00000352246
resolver
ensp
ENSMUSP00000352247
resolver
enst
ENSMUST00000224478
resolver
genesymbol
Btrc
resolver
genesymbol_syn
Fbw1
resolver
genesymbol_syn
Fbxw1
resolver
genesymbol_syn
Fwd1
resolver
genesymbol_syn
Kiaa4123
resolver
uniprot
A0A286YDT6
resolver
uniprot
Q3U0Q4
resolver
uniprot
Q571K6
resolver
uniprot
Q9QUI5
resolver
uniprot
Q9R1G7
resolver
uniprot
Q9Z159
resolver
uniprot_entry
A0A286YDT6_MOUSE
resolver
uniprot_entry
FBW1A_MOUSE
resolver
uniprot_sec
Q3U0Q4
resolver
uniprot_sec
Q571K6
resolver
uniprot_sec
Q9QUI5
resolver
uniprot_sec
Q9R1G7
resolver
uniprot_sec
Q9Z159
resolver
amino_acid_sequence
MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCINQETVCLTSTAMKTENCVAKAKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDENAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKSTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNAGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLMAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAHAEPPRSPSRTYTYISR
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10097128, PubMed:16371461, PubMed:16611981, PubMed:18782782, PubMed:21911472, PubMed:29593216, PubMed:9859996, PubMed:9990853). Recognizes and binds to phosphorylated target proteins (PubMed:10097128, PubMed:16371461, PubMed:16611981, PubMed:18782782, PubMed:21911472, PubMed:9859996, PubMed:9990853). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (By similarity). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10097128, PubMed:9859996). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10097128, PubMed:9859996). The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation (By similarity). SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (PubMed:21911472). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:18782782). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase (By similarity). Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF (By similarity). SCF(BTRC) acts as a negative regulator of smoothened signaling by mediating ubiquitination of GLI2 and GLI3 in absence of smoothened, promoting their processing into transcription repressors (PubMed:16371461, PubMed:16611981). Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (By similarity). SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216). SCF(BTRC) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF (By similarity). SCF(BTRC) directs 'Lys-48'-linked ubiquitination of UBR2 in the T-cell receptor signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q9Y297, ECO:0000269|PubMed:10097128, ECO:0000269|PubMed:16371461, ECO:0000269|PubMed:16611981, ECO:0000269|PubMed:18782782, ECO:0000269|PubMed:21911472, ECO:0000269|PubMed:29593216, ECO:0000269|PubMed:9859996, ECO:0000269|PubMed:9990853}.
uniprot
proteins
mass_dalton
68923
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:10097128, ECO:0000269|PubMed:16371461, ECO:0000269|PubMed:16611981, ECO:0000269|PubMed:21911472, ECO:0000269|PubMed:29593216, ECO:0000269|PubMed:9859996, ECO:0000269|PubMed:9990853}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated via 'Lys-11'-linked polyubiquitin by some cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex), leading to its degradation. Deubiquitinated by OTUD5, promoting its stability. {ECO:0000250|UniProtKB:Q9Y297}.
uniprot
proteins
pubmed
10097128
uniprot
proteins
pubmed
10531037
uniprot
proteins
pubmed
11735228
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15917222
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16371461
uniprot
proteins
pubmed
16611981
uniprot
proteins
pubmed
18782782
uniprot
proteins
pubmed
21911472
uniprot
proteins
pubmed
22037600
uniprot
proteins
pubmed
29593216
uniprot
proteins
pubmed
9859996
uniprot
proteins
pubmed
9990853
uniprot
proteins
sequence_length
605
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11735228}. Nucleus {ECO:0000269|PubMed:11735228}.
uniprot
proteins