SH2D1B
entrez
117157
canonical
uniprot
O14796
canonical
ensembl
ENSG00000198574
resolver
ensp
ENSP00000356906
resolver
genesymbol
SH2D1B
resolver
genesymbol_syn
EAT2
resolver
hgnc
HGNC:30416
resolver
uniprot
B2RBN6
resolver
uniprot
Q5T0L1
resolver
uniprot
Q8NI18
resolver
uniprot
Q969K9
resolver
uniprot_entry
SH21B_HUMAN
resolver
uniprot_sec
B2RBN6
resolver
uniprot_sec
Q5T0L1
resolver
uniprot_sec
Q8NI18
resolver
uniprot_sec
Q969K9
resolver
amino_acid_sequence
MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLKLELETFVNSNSDYVDVLP
uniprot
proteins
function
FUNCTION: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity). {ECO:0000250|UniProtKB:O35324, ECO:0000269|PubMed:11689425, ECO:0000269|PubMed:24687958, ECO:0000305|PubMed:21219180}.
uniprot
proteins
mass_dalton
15297
uniprot
proteins
mutagenesis
MUTAGEN 127; /note="Y->F: No stimulation of granule polarization during NK-mediated cytotoxicity, abolishes activation of CD244/2B4-mediated cytotoxicity, abolishes augmentation of CD244/2B4-triggered PLCG1 phosphorylation and ERK activation."; /evidence="ECO:0000269|PubMed:24687958
uniprot
proteins
pubmed
11689425
uniprot
proteins
pubmed
12115647
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21219180
uniprot
proteins
pubmed
24687958
uniprot
proteins
pubmed
9000139
uniprot
proteins
sequence_length
132
uniprot
proteins