Kcne3
entrez
57442
canonical
uniprot
Q9WTW2
canonical
ensembl
ENSMUSG00000035165
resolver
ensp
ENSMUSP00000039353
resolver
ensp
ENSMUSP00000130019
resolver
ensp
ENSMUSP00000136415
resolver
ensp
ENSMUSP00000136616
resolver
ensp
ENSMUSP00000146583
resolver
ensp
ENSMUSP00000147047
resolver
ensp
ENSMUSP00000147151
resolver
ensp
ENSMUSP00000234979
resolver
ensp
ENSMUSP00000351934
resolver
enst
ENSMUST00000049333
resolver
enst
ENSMUST00000170954
resolver
enst
ENSMUST00000178946
resolver
enst
ENSMUST00000179842
resolver
enst
ENSMUST00000207358
resolver
enst
ENSMUST00000207995
resolver
enst
ENSMUST00000208260
resolver
genesymbol
Kcne3
resolver
uniprot
Q545H9
resolver
uniprot_entry
KCNE3_MOUSE
resolver
uniprot_entry
Q545H9_MOUSE
resolver
amino_acid_sequence
METSNGTETWYMSLHAVLKALNTTLHSHLLCRPGPGPGPDNQTEDRRASLPGRNDNSYMYILFVMFLFAVTVGSLILGYTRSRKVDKRSDPYHVYIKNRVSMI
uniprot
proteins
function
FUNCTION: Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE3 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit. Associates with KCNC4/Kv3.4 alpha subunit to form the subthreshold Kv channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells (By similarity). Association with KCNQ1/KCLQT1 alpha subunit may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship (By similarity). {ECO:0000250|UniProtKB:Q9JJV7, ECO:0000250|UniProtKB:Q9Y6H6}.
uniprot
proteins
mass_dalton
11720
uniprot
proteins
protein_family
Potassium channel KCNE family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
103
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9JJV7, ECO:0000250|UniProtKB:Q9Y6H6}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9Y6H6}. Cytoplasm {ECO:0000250|UniProtKB:Q9JJV7, ECO:0000250|UniProtKB:Q9Y6H6}. Perikaryon {ECO:0000250|UniProtKB:Q9Y6H6}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9Y6H6}. Membrane raft {ECO:0000250|UniProtKB:Q9Y6H6}. Note=Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal neurons. {ECO:0000250|UniProtKB:Q9Y6H6}.
uniprot
proteins
transmembrane_region
TRANSMEM 57..77; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9Y6H6
uniprot
proteins