Oprd1
entrez
24613
canonical
uniprot
P33533
canonical
ensembl
ENSRNOG00000010531
resolver
ensembl
ENSRNOG00055025285
resolver
ensembl
ENSRNOG00060022110
resolver
ensembl
ENSRNOG00065027771
resolver
ensp
ENSRNOP00000014084
resolver
ensp
ENSRNOP00055035580
resolver
ensp
ENSRNOP00060031562
resolver
ensp
ENSRNOP00065039267
resolver
enst
ENSRNOT00000014084
resolver
enst
ENSRNOT00055043589
resolver
enst
ENSRNOT00060038284
resolver
enst
ENSRNOT00065047858
resolver
genesymbol
Oprd1
resolver
genesymbol_syn
Ror-a
resolver
uniprot_entry
OPRD_RAT
resolver
amino_acid_sequence
MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. {ECO:0000269|PubMed:7519274, ECO:0000269|PubMed:8394245}.
uniprot
proteins
mass_dalton
40450
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. A basal ubiquitination does not seem to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4. {ECO:0000250|UniProtKB:P32300}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
7519274
uniprot
proteins
pubmed
8394245
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7519274, ECO:0000269|PubMed:8394245}; Multi-pass membrane protein {ECO:0000269|PubMed:7519274, ECO:0000269|PubMed:8394245}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..75; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 86..110; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 123..144; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 164..186; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 207..238; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 262..284; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 300..321; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins