HEPACAM2
entrez
253012
canonical
uniprot
A8MVW5
canonical
ensembl
ENSG00000188175
resolver
ensp
ENSP00000340532
resolver
ensp
ENSP00000377980
resolver
ensp
ENSP00000389592
resolver
ensp
ENSP00000390204
resolver
enst
ENST00000440868
resolver
genesymbol
HEPACAM2
resolver
genesymbol_syn
MIKI
resolver
hgnc
HGNC:27364
resolver
uniprot
B3KTT4
resolver
uniprot
B4DPJ1
resolver
uniprot
B9EG93
resolver
uniprot
C9JN07
resolver
uniprot
E9PDV5
resolver
uniprot
Q6UXI0
resolver
uniprot_entry
C9JN07_HUMAN
resolver
uniprot_entry
HECA2_HUMAN
resolver
uniprot_sec
B3KTT4
resolver
uniprot_sec
B4DPJ1
resolver
uniprot_sec
B9EG93
resolver
uniprot_sec
E9PDV5
resolver
uniprot_sec
Q6UXI0
resolver
amino_acid_sequence
MGQDAFMEPFGDTLGVFQCKIYLLLFGACSGLKVTVPSHTVHGVRGQALYLPVHYGFHTPASDIQIIWLFERPHTMPKYLLGSVNKSVVPDLEYQHKFTMMPPNASLLINPLQFPDEGNYIVKVNIQGNGTLSASQKIQVTVDDPVTKPVVQIHPPSGAVEYVGNMTLTCHVEGGTRLAYQWLKNGRPVHTSSTYSFSPQNNTLHIAPVTKEDIGNYSCLVRNPVSEMESDIIMPIIYYGPYGLQVNSDKGLKVGEVFTVDLGEAILFDCSADSHPPNTYSWIRRTDNTTYIIKHGPRLEVASEKVAQKTMDYVCCAYNNITGRQDETHFTVIITSVGLEKLAQKGKSLSPLASITGISLFLIISMCLLFLWKKYQPYKVIKQKLEGRPETEYRKAQTFSGHEDALDDFGIYEFVAFPDVSGVSRIPSRSVPASDCVSGQDLHSTVYEVIQHIPAQQQDHPE
uniprot
proteins
function
FUNCTION: Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation. {ECO:0000269|PubMed:22864114}.
uniprot
proteins
mass_dalton
51407
uniprot
proteins
post_translational_modification
PTM: Poly-ADP-ribosylated (PARsylated) by tankyrase TNKS during late G2 and prophase, leading to translocation to mitotic centrosomes.; PTM: N-glycosylated. {ECO:0000269|PubMed:19358830, ECO:0000269|PubMed:22864114}.
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19358830
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
22864114
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:19358830, ECO:0000269|PubMed:22864114}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19358830, ECO:0000269|PubMed:22864114}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19358830, ECO:0000269|PubMed:22864114}. Midbody {ECO:0000269|PubMed:22864114}. Note=In interphase, localizes to the Golgi apparatus. Localizes to centrosomes and spindles during prophase, prometaphase, and metaphase of mitosis, and to midbodies at telophase. Translocation to mitotic centrosomes is the result of poly-ADP-ribosylation (PARsylation). {ECO:0000269|PubMed:19358830, ECO:0000269|PubMed:22864114}.
uniprot
proteins
transmembrane_region
TRANSMEM 352..372; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins