SLC46A3
entrez
283537
canonical
uniprot
Q7Z3Q1
canonical
ensembl
ENSG00000139508
resolver
ensp
ENSP00000266943
resolver
ensp
ENSP00000370192
resolver
ensp
ENSP00000548190
resolver
genesymbol
SLC46A3
resolver
hgnc
HGNC:27501
resolver
uniprot
Q3ZCV8
resolver
uniprot
Q6NUK5
resolver
uniprot
Q6P9B3
resolver
uniprot
Q6ZVG5
resolver
uniprot
Q96QA1
resolver
uniprot_entry
S46A3_HUMAN
resolver
uniprot_sec
Q3ZCV8
resolver
uniprot_sec
Q6NUK5
resolver
uniprot_sec
Q6P9B3
resolver
uniprot_sec
Q6ZVG5
resolver
uniprot_sec
Q96QA1
resolver
amino_acid_sequence
MKILFVEPAIFLSAFAMTLTGPLTTQYVYRRIWEETGNYTFSSDSNISECEKNKSSPIFAFQEEVQKKVSRFNLQMDISGLIPGLVSTFILLSISDHYGRKFPMILSSVGALATSVWLCLLCYFAFPFQLLIASTFIGAFCGNYTTFWGACFAYIVDQCKEHKQKTIRIAIIDFLLGLVTGLTGLSSGYFIRELGFEWSFLIIAVSLAVNLIYILFFLGDPVKECSSQNVTMSCSEGFKNLFYRTYMLFKNASGKRRFLLCLLLFTVITYFFVVIGIAPIFILYELDSPLCWNEVFIGYGSALGSASFLTSFLGIWLFSYCMEDIHMAFIGIFTTMTGMAMTAFASTTLMMFLARVPFLFTIVPFSVLRSMLSKVVRSTEQGTLFACIAFLETLGGVTAVSTFNGIYSATVAWYPGFTFLLSAGLLLLPAISLCVVKCTSWNEGSYELLIQEESSEDASDR
uniprot
proteins
function
FUNCTION: Lysosomal proton-coupled steroid conjugate and bile acid transporter. Preferentially recognizes lipophilic steroid conjugates or bile acis as endogenous substrates and seems to mediate escape from lysosomes to the cytoplasm (PubMed:36741448). Modulates hepatic cytosolic copper homeostasis, maybe acting as a lysosomal copper transporter and sequestering copper ions in the lysosome (By similarity). Transports catabolites of non-cleavable antibody-drug conjugates from the lysosome to the cytoplasm (PubMed:26631267, PubMed:30131388, PubMed:36741448). Delivers pathogen-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes. Selectively transports bacterial muramyl dipeptide (MDP) into the cytosol for recognition by NOD2, triggering inflammatory responses (By similarity). Likely acts as a redundant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages (PubMed:34235268). The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable). {ECO:0000250|UniProtKB:Q9DC26, ECO:0000269|PubMed:26631267, ECO:0000269|PubMed:30131388, ECO:0000269|PubMed:34235268, ECO:0000269|PubMed:36741448, ECO:0000305}.
uniprot
proteins
mass_dalton
51519
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
SLC46A family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
26631267
uniprot
proteins
pubmed
30131388
uniprot
proteins
pubmed
34235268
uniprot
proteins
pubmed
35862544
uniprot
proteins
pubmed
36741448
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:26631267, ECO:0000269|PubMed:35862544, ECO:0000269|PubMed:36741448}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 74..94; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 102..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 134..156; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 171..191; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 198..218; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 262..282; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 295..315; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 325..345; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 348..368; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 383..403; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 416..436; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins