NFE2
entrez
4778
canonical
uniprot
Q16621
canonical
ensembl
ENSG00000123405
resolver
ensp
ENSP00000312436
resolver
ensp
ENSP00000397185
resolver
ensp
ENSP00000439120
resolver
ensp
ENSP00000446929
resolver
ensp
ENSP00000447558
resolver
ensp
ENSP00000566068
resolver
ensp
ENSP00000566069
resolver
ensp
ENSP00000566070
resolver
ensp
ENSP00000566071
resolver
ensp
ENSP00000598804
resolver
ensp
ENSP00000598805
resolver
ensp
ENSP00000611334
resolver
ensp
ENSP00000611335
resolver
enst
ENST00000312156
resolver
enst
ENST00000435572
resolver
enst
ENST00000540264
resolver
enst
ENST00000553070
resolver
enst
ENST00000896009
resolver
enst
ENST00000896010
resolver
enst
ENST00000896011
resolver
enst
ENST00000896012
resolver
enst
ENST00000928745
resolver
enst
ENST00000928746
resolver
enst
ENST00000941275
resolver
enst
ENST00000941276
resolver
genesymbol
NFE2
resolver
hgnc
HGNC:7780
resolver
uniprot
A8K3E0
resolver
uniprot
Q07720
resolver
uniprot
Q6ICV9
resolver
uniprot_entry
A8K3E0_HUMAN
resolver
uniprot_entry
NFE2_HUMAN
resolver
uniprot_sec
Q07720
resolver
uniprot_sec
Q6ICV9
resolver
amino_acid_sequence
MSPCPPQQSRNRVIQLSTSELGEMELTWQEIMSITELQGLNAPSEPSFEPQAPAPYLGPPPPTTYCPCSIHPDSGFPLPPPPYELPASTSHVPDPPYSYGNMAIPVSKPLSLSGLLSEPLQDPLALLDIGLPAGPPKPQEDPESDSGLSLNYSDAESLELEGTEAGRRRSEYVEMYPVEYPYSLMPNSLAHSNYTLPAAETPLALEPSSGPVRAKPTARGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLARYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLTNERERLLRARGEADRTLEVMRQQLTELYRDIFQHLRDESGNSYSPEEYALQQAADGTIFLVPRGTKMEATD
uniprot
proteins
function
FUNCTION: Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. {ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:16287851}.
uniprot
proteins
mass_dalton
41473
uniprot
proteins
mutagenesis
MUTAGEN 368; /note="K->R: 60% loss of DNA-binding and 5-fold loss of transactivation activity. Almost no colocalization with nuclear bodies."; /evidence="ECO:0000269|PubMed:16287851
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues. In undifferentiated erythrocytes, phosphorylated by MAPK8 which then leads to ubiquitination and protein degradation. {ECO:0000250}.; PTM: Sumoylated. Sumoylation is required for translocation to nuclear bodies PODs, anchoring to the gene loci, and transactivation of the beta-globin gene. {ECO:0000269|PubMed:16287851}.; PTM: Ubiquitinated mainly by 'Lys63'-linked ubiquitin. Polyubiquitination with 'Lys63'-linked ubiquitin by ITCH retains NFE2 in the cytoplasm preventing its transactivation activity. In undifferentiated erythrocyte, ubiquitinated after MAPK8-mediatd phosphorylation leading to protein degradation (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
CNC subfamily
uniprot
proteins
pubmed
11154691
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16287851
uniprot
proteins
pubmed
18718448
uniprot
proteins
pubmed
7724591
uniprot
proteins
pubmed
8248255
uniprot
proteins
pubmed
8355703
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, PML body. Cytoplasm. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH.
uniprot
proteins