RASSF5
entrez
83593
canonical
uniprot
Q8WWW0
canonical
ensembl
ENSG00000266094
resolver
ensp
ENSP00000462099
resolver
ensp
ENSP00000462544
resolver
ensp
ENSP00000462576
resolver
genesymbol
RASSF5
resolver
genesymbol_syn
NORE1
resolver
genesymbol_syn
RAPL
resolver
hgnc
HGNC:17609
resolver
uniprot
A8K1E6
resolver
uniprot
A8K5F3
resolver
uniprot
Q5SY32
resolver
uniprot
Q8WWV9
resolver
uniprot
Q8WXF4
resolver
uniprot
Q9BT99
resolver
uniprot_entry
A8K5F3_HUMAN
resolver
uniprot_entry
RASF5_HUMAN
resolver
uniprot_sec
A8K1E6
resolver
uniprot_sec
Q5SY32
resolver
uniprot_sec
Q8WWV9
resolver
uniprot_sec
Q8WXF4
resolver
uniprot_sec
Q9BT99
resolver
amino_acid_sequence
MAMASPAIGQRPYPLLLDPEPPRYLQSLSGPELPPPPPDRSSRLCVPAPLSTAPGAREGRSARRAARGNLEPPPRASRPARPLRPGLQQRLRRRPGAPRPRDVRSIFEQPQDPRVPAERGEGHCFAELVLPGGPGWCDLCGREVLRQALRCTNCKFTCHPECRSLIQLDCSQQEGLSRDRPSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEALRESQGKPG
uniprot
proteins
function
FUNCTION: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. {ECO:0000269|PubMed:12676952, ECO:0000269|PubMed:12845325, ECO:0000269|PubMed:15569673}.
uniprot
proteins
mass_dalton
47090
uniprot
proteins
pubmed
11965544
uniprot
proteins
pubmed
12676952
uniprot
proteins
pubmed
12845325
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15109305
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15569673
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
31130282
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
uniprot
proteins