Dpysl2
entrez
12934
canonical
uniprot
O08553
canonical
ensembl
ENSMUSG00000022048
resolver
ensp
ENSMUSP00000022629
resolver
ensp
ENSMUSP00000160026
resolver
enst
ENSMUST00000022629
resolver
enst
ENSMUST00000249932
resolver
genesymbol
Dpysl2
resolver
genesymbol_syn
Crmp2
resolver
genesymbol_syn
Ulip2
resolver
uniprot
A0AAQ4VMY7
resolver
uniprot
Q6P5D0
resolver
uniprot_entry
A0AAQ4VMY7_MOUSE
resolver
uniprot_entry
DPYL2_MOUSE
resolver
uniprot_sec
Q6P5D0
resolver
amino_acid_sequence
MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLHVDITEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDSQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRSITIANQTNCPLYVTKVMSKSAAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRISVGSDADLVIWDPDSVKTISAKTHNSALEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFSLSGAQIDDNIPRRTTQRIVAPPGGRANITSLG
uniprot
proteins
function
FUNCTION: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:22057101}.
uniprot
proteins
mass_dalton
62278
uniprot
proteins
mutagenesis
MUTAGEN 514; /note="T->A: Delayed neurite degeneration."; /evidence="ECO:0000269|PubMed:22057101
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B (By similarity). Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration. {ECO:0000250, ECO:0000269|PubMed:22057101}.
uniprot
proteins
protein_family
Hydantoinase/dihydropyrimidinase family
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
pubmed
10956643
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15466885
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15648052
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22057101
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
9375656
uniprot
proteins
pubmed
9652388
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}. Note=Tightly but non-covalently associated with membranes. {ECO:0000250}.
uniprot
proteins