LATS2
entrez
26524
canonical
uniprot
Q9NRM7
canonical
ensembl
ENSG00000150457
resolver
ensp
ENSP00000372035
resolver
ensp
ENSP00000576178
resolver
ensp
ENSP00000576179
resolver
ensp
ENSP00000610362
resolver
enst
ENST00000382592
resolver
enst
ENST00000906119
resolver
enst
ENST00000906120
resolver
enst
ENST00000940303
resolver
genesymbol
LATS2
resolver
genesymbol_syn
KPM
resolver
hgnc
HGNC:6515
resolver
uniprot
B1AM47
resolver
uniprot
Q9P2X1
resolver
uniprot_entry
LATS2_HUMAN
resolver
uniprot_sec
B1AM47
resolver
uniprot_sec
Q9P2X1
resolver
amino_acid_sequence
MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQQQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSFASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVEAAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLYELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGMEQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQTEGCQPVYV
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}.
uniprot
proteins
mass_dalton
120136
uniprot
proteins
mutagenesis
MUTAGEN 83; /note="S->C: Fails to localize at the centromere during interphase."; /evidence="ECO:0000269|PubMed:15147269"; MUTAGEN 83; /note="S->E: Fails to localize at the centromere during interphase."; /evidence="ECO:0000269|PubMed:15147269"; MUTAGEN 697; /note="K->A: Loss of kinase activity, autophosphorylation and tumor suppressor activity."; /evidence="ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976"; MUTAGEN 872; /note="S->A: Loss of tumor suppressor activity."; /evidence="ECO:0000269|PubMed:12853976
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated and phosphorylated during M-phase and the G1/S-phase of the cell cycle (PubMed:15147269, PubMed:21952048). Phosphorylated and activated by STK3/MST2 (PubMed:15688006). Phosphorylated by MAP4Ks; in parallel to STK3/MST2 and resulting to its activation (PubMed:26437443). Phosphorylation by NUAK2 may regulate its activity in phosphorylation and inactivation YAP1 (PubMed:32845958). {ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:32845958}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10673337
uniprot
proteins
pubmed
10871863
uniprot
proteins
pubmed
12853976
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15131260
uniprot
proteins
pubmed
15147269
uniprot
proteins
pubmed
15688006
uniprot
proteins
pubmed
16413547
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18158288
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19739119
uniprot
proteins
pubmed
20303269
uniprot
proteins
pubmed
21952048
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24682284
uniprot
proteins
pubmed
26437443
uniprot
proteins
pubmed
26598551
uniprot
proteins
pubmed
32845958
uniprot
proteins
pubmed
34404733
uniprot
proteins
pubmed
39173637
uniprot
proteins
sequence_length
1088
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment.
uniprot
proteins