Syn1
entrez
24949
canonical
uniprot
P09951
canonical
ensembl
ENSRNOG00000010365
resolver
ensembl
ENSRNOG00055016372
resolver
ensembl
ENSRNOG00060020591
resolver
ensembl
ENSRNOG00065020264
resolver
ensp
ENSRNOP00000014250
resolver
ensp
ENSRNOP00000106852
resolver
genesymbol
Syn1
resolver
uniprot
Q9WUX7
resolver
uniprot_entry
SYN1_RAT
resolver
uniprot_sec
Q9WUX7
resolver
amino_acid_sequence
MNYLRRRLSDSNFMANLPNGYMTDLQRPQPPPPPPSAASPGATPGSAAASAERASTAAPVASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGGSGGAGRGGAAARVLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFSMARNGDYRSLVIGLQYAGIPSVNSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIASVVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMTQALPRQRDASPGRGSHSQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTAAPQQSASQATPMTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQASISGPAPPKVSGASPGGQQRQGPPQKPPGPAGPIRQASQAGPGPRTGPPTTQQPRPSGPGPAGRPTKPQLAQKPSQDVPPPIIAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDEVKAETIRSLRKSFASLFSD
uniprot
proteins
function
FUNCTION: Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:11685225). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level (PubMed:11867766). {ECO:0000250|UniProtKB:O88935, ECO:0000269|PubMed:11685225, ECO:0000269|PubMed:11867766}.
uniprot
proteins
mass_dalton
73988
uniprot
proteins
post_translational_modification
PTM: Substrate of different protein kinases. Phosphorylation, including phosphorylation at Ser-9, promotes synapsin-1 dissociation from synaptic vesicles, regulates its rate of dispersion, and controls the kinetics of vesicle pool turnover (PubMed:10571231, PubMed:11685225). {ECO:0000269|PubMed:10571231, ECO:0000269|PubMed:11685225}.
uniprot
proteins
protein_family
Synapsin family
uniprot
proteins
pubmed
10386995
uniprot
proteins
pubmed
10571231
uniprot
proteins
pubmed
11685225
uniprot
proteins
pubmed
11867766
uniprot
proteins
pubmed
12438562
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2506642
uniprot
proteins
pubmed
3028773
uniprot
proteins
pubmed
3118371
uniprot
proteins
sequence_length
704
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:O88935}. Golgi apparatus {ECO:0000250|UniProtKB:O88935}. Presynapse {ECO:0000269|PubMed:11685225}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:11685225}. Note=Dissociates from synaptic vesicles and redistributes into the axon during action potential firing, in a step that precedes fusion of vesicles with the plasma membrane. Reclusters to presynapses after the cessation of synaptic activity. {ECO:0000269|PubMed:11685225}.
uniprot
proteins