TREH
entrez
11181
canonical
uniprot
O43280
canonical
ensembl
ENSG00000118094
resolver
ensp
ENSP00000264029
resolver
ensp
ENSP00000381020
resolver
genesymbol
TREH
resolver
genesymbol_syn
TREA
resolver
hgnc
HGNC:12266
resolver
uniprot
Q32MB9
resolver
uniprot
Q53FY8
resolver
uniprot_entry
TREA_HUMAN
resolver
uniprot_sec
Q32MB9
resolver
uniprot_sec
Q53FY8
resolver
amino_acid_sequence
MPGRTWELCLLLLLGLGLGSQEALPPPCESEIYCHGELLNQVQMAKLYQDDKQFVDMPLSIAPEQVLQTFTELSRDHNHSIPREQLQAFVHEHFQAKGQELQPWTPADWKDSPQFLQKISDAKLRAWAGQLHQLWKKLGKKMKPEVLSHPERFSLIYSEHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMAETVKGMLQNFLDLVKTYGHVPNGGRVYYLQRSQPPLLTLMMDCYLTHTNDTAFLQENIETLALELDFWTKNRTVSVSLEGKNYLLNRYYVPYGGPRPESYSKDVELADTLPEGDREALWAELKAGAESGWDFSSRWLIGGPNPNSLSGIRTSKLVPVDLNAFLCQAEELMSNFYSRLGNDSQATKYRILRSQRLAALNTVLWDEQTGAWFDYDLEKKKKNREFYPSNLTPLWAGCFSDPGVADKALKYLEDNRILTYQYGIPTSLQKTGQQWDFPNAWAPLQDLVIRGLAKAPLRRAQEVAFQLAQNWIRTNFDVYSQKSAMYEKYDVSNGGQPGGGGEYEVQEGFGWTNGVVLMLLDRYGDRLTSGAKLAFLEPHCLAATLLPSLLLSLLPW
uniprot
proteins
disease_involvement
DISEASE: Trehalase deficiency (TREHD) [MIM:612119]: An autosomal recessive condition characterized by the inability to digest trehalose, a disaccharide found in mushrooms, products containing baker's yeast, and dried food. Individuals with trehalase deficiency suffer from abdominal pain, increased rectal flatulence, and diarrhea due to osmotic water flow into the colon. {ECO:0000269|PubMed:28406212}. Note=The gene represented in this entry is involved in disease pathogenesis.
uniprot
proteins
ec_number
3.2.1.28
uniprot
proteins
function
FUNCTION: Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose. {ECO:0000269|PubMed:8773341, ECO:0000269|PubMed:9427547}.
uniprot
proteins
mass_dalton
66568
uniprot
proteins
protein_family
Glycosyl hydrolase 37 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28406212
uniprot
proteins
pubmed
8773341
uniprot
proteins
pubmed
9427547
uniprot
proteins
sequence_length
583
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P19813}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19813}.
uniprot
proteins