Dhcr24
entrez
298298
canonical
uniprot
Q5BQE6
canonical
ensembl
ENSRNOG00000006787
resolver
ensembl
ENSRNOG00055031818
resolver
ensembl
ENSRNOG00060020233
resolver
ensembl
ENSRNOG00065022441
resolver
ensp
ENSRNOP00000009402
resolver
ensp
ENSRNOP00055045511
resolver
ensp
ENSRNOP00060028803
resolver
ensp
ENSRNOP00065030985
resolver
enst
ENSRNOT00000009402
resolver
enst
ENSRNOT00055055067
resolver
enst
ENSRNOT00060035053
resolver
enst
ENSRNOT00065038273
resolver
genesymbol
Dhcr24
resolver
uniprot
A1KXK4
resolver
uniprot_entry
A1KXK4_RAT
resolver
uniprot_entry
DHC24_RAT
resolver
amino_acid_sequence
MEPAVSLAVCALLFLLWVRVKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVQDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVSMGQVTALLNSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELILADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICEKFTHESQRLENHFVEGLLYSLDEAVIMTGVMTDDVEPSKLNSIGSYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLSQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGDEAELYVDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLRKQLGCQDAFPEVYDKICKAARH
uniprot
proteins
ec_number
1.3.1.72
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis. {ECO:0000250|UniProtKB:Q15392}.
uniprot
proteins
mass_dalton
60047
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; cholesterol biosynthesis. {ECO:0000250|UniProtKB:Q15392}.
uniprot
proteins
protein_family
FAD-binding oxidoreductase/transferase type 4 family
uniprot
proteins
sequence_length
516
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15392}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q15392}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins