Mospd2
entrez
76763
canonical
uniprot
Q9CWP6
canonical
ensembl
ENSMUSG00000061778
resolver
ensp
ENSMUSP00000004715
resolver
ensp
ENSMUSP00000107866
resolver
ensp
ENSMUSP00000107867
resolver
ensp
ENSMUSP00000279857
resolver
ensp
ENSMUSP00000279858
resolver
ensp
ENSMUSP00000279862
resolver
enst
ENSMUST00000004715
resolver
genesymbol
Mospd2
resolver
uniprot
B1AU74
resolver
uniprot
Q8BYF8
resolver
uniprot
Q8BZB6
resolver
uniprot
Q8C0G1
resolver
uniprot
Q8R0T7
resolver
uniprot_entry
B1AU74_MOUSE
resolver
uniprot_entry
MSPD2_MOUSE
resolver
uniprot_sec
Q8BYF8
resolver
uniprot_sec
Q8BZB6
resolver
uniprot_sec
Q8C0G1
resolver
uniprot_sec
Q8R0T7
resolver
amino_acid_sequence
MAENNAQNKAKLISETRRRFEAEYVTEKSEKYDSRDVERLQQDDNWVESYLYWRHNVVDETLKMLDESFQWRKEFSVNDLSESSIPRWLLELGGIYLHGYDKEGNKLFWIRVKYHIKDQKTIMDKKKLIAFWLERYAKRENGKPITVMFDMSETGLNSIDMDFVRFIINCFKVYYPKYLSKIVIFDMPWIMNAAFKIVKSWLGPEAVSLLKFTSKNEIQEYVSVEYLPPHMGGTDPFKYSYPPLVDDDFQTPLCENGPIASEDETSSKEDIEGDGKETLETISNEEPPALSEKSNPTESVSKKDENEKVDSKTKTFKKPLSVFKGPLLHISPAEELYFGSIESGEKKTLIVLTNVTKNIVAFKVRTTAPEKYRVKPSNSSCDPGASIDIIVSPHGGLTVSAQDRFLIMAAEMEQSSGTGPAELSQFWKEVPRNKVMEHRLRCHTVESSKPNSLMLKDSISTMSDKTSEDLYLQLNRLLESNRKLEDQLQRSIWFQQLLLALTMVLLDFVVSFFYSLYN
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins. In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis. The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs. Promotes migration of primary monocytes and neutrophils, in response to various chemokines. {ECO:0000250|UniProtKB:Q8NHP6}.
uniprot
proteins
mass_dalton
59855
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
518
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8NHP6}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8NHP6}. Note=Localization to contact sites involving the endoplasmic reticulum and several organelles is regulated by interaction with proteins containing FFAT motif. Dynamically distributes between specific subdomains of the endoplasmic reticulum (ER): ER membranes in contact with lipid droplets (LDs) and the remainder of the ER. {ECO:0000250|UniProtKB:Q8NHP6}.
uniprot
proteins
transmembrane_region
TRANSMEM 497..518; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000250|UniProtKB:Q8NHP6
uniprot
proteins