Tspo2
entrez
70026
canonical
uniprot
Q9CRZ8
canonical
ensembl
ENSMUSG00000023995
resolver
ensp
ENSMUSP00000024794
resolver
ensp
ENSMUSP00000329400
resolver
enst
ENSMUST00000024794
resolver
genesymbol
Tspo2
resolver
genesymbol_syn
Bzrpl1
resolver
uniprot_entry
TSPO2_MOUSE
resolver
amino_acid_sequence
MQLQGPVFVGVPLLGPILICMLIHQPSSRCEDERKLPWCPPHKVILLVWVTIYSVMGYASYLVWKELGGGFRWPLALPLGLYSFQLALSWTFLVLFLAADSPGLALLDLLLLYGLVASLVFIWQPINKLAALLLLPYLAWLTVTTAITYRLWRDSLCPTYQP
uniprot
proteins
function
FUNCTION: Cholesterol-binding protein involved in the redistribution of cholesterol from lipid droplets to the endoplasmic reticulum (PubMed:19729679, PubMed:32358067). Required to meet cholesterol demands during erythropoietic differentiation (PubMed:19729679, PubMed:32358067). May play a role in transport processes at the plasma membrane of erythrocytes, including regulating VDAC-mediated ATP export, and import of the heme precursors protoporphyrin IX and 5-aminolevulinic acid (By similarity). {ECO:0000250|UniProtKB:Q5TGU0, ECO:0000269|PubMed:19729679, ECO:0000269|PubMed:32358067}.
uniprot
proteins
mass_dalton
18286
uniprot
proteins
protein_family
TspO/BZRP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19729679
uniprot
proteins
pubmed
32358067
uniprot
proteins
sequence_length
162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19729679}; Multi-pass membrane protein {ECO:0000269|PubMed:19729679}. Cell membrane {ECO:0000250|UniProtKB:Q5TGU0}; Multi-pass membrane protein. Note=Localizes to the plasma membrane and intracellular membranes in developing and mature erythrocytes. {ECO:0000250|UniProtKB:Q5TGU0}.
uniprot
proteins
transmembrane_region
TRANSMEM 3..23; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 44..64; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 129..149; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins