EVI5
entrez
7813
canonical
uniprot
O60447
canonical
ensembl
ENSG00000067208
resolver
ensp
ENSP00000359356
resolver
ensp
ENSP00000440826
resolver
ensp
ENSP00000506999
resolver
ensp
ENSP00000516584
resolver
ensp
ENSP00000516588
resolver
ensp
ENSP00000516594
resolver
ensp
ENSP00000516595
resolver
ensp
ENSP00000603899
resolver
ensp
ENSP00000618864
resolver
ensp
ENSP00000618865
resolver
ensp
ENSP00000618873
resolver
enst
ENST00000684568
resolver
enst
ENST00000706843
resolver
enst
ENST00000706846
resolver
enst
ENST00000706867
resolver
enst
ENST00000706868
resolver
enst
ENST00000948805
resolver
enst
ENST00000948806
resolver
enst
ENST00000948814
resolver
genesymbol
EVI5
resolver
genesymbol_syn
NB4S
resolver
hgnc
HGNC:3501
resolver
uniprot
A0A804HIC4
resolver
uniprot
A0A9L9PXE3
resolver
uniprot
A0A9L9PXL1
resolver
uniprot
A0A9L9PYE8
resolver
uniprot
A6NKX8
resolver
uniprot
B9A6J0
resolver
uniprot
Q59FE7
resolver
uniprot
Q9H1Y9
resolver
uniprot_entry
A0A804HIC4_HUMAN
resolver
uniprot_entry
A0A9L9PXE3_HUMAN
resolver
uniprot_entry
A0A9L9PXL1_HUMAN
resolver
uniprot_entry
A0A9L9PYE8_HUMAN
resolver
uniprot_entry
EVI5_HUMAN
resolver
uniprot_entry
Q59FE7_HUMAN
resolver
uniprot_sec
A6NKX8
resolver
uniprot_sec
B9A6J0
resolver
uniprot_sec
Q9H1Y9
resolver
amino_acid_sequence
MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTSSSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRIETLEKHKCSSNYNEDFVLQLEKELVQARLSEAESQCALKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQRHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNHLRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAAVAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRCLKGQRGFSGQPPFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESETEDSVLETRESNQVVQKERPPRRRESYSTTV
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma. Translocation t(1;10)(p22;q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural transcript which is normally not translated. {ECO:0000269|PubMed:9618176}.
uniprot
proteins
function
FUNCTION: Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis. {ECO:0000269|PubMed:16439210}.
uniprot
proteins
mass_dalton
92949
uniprot
proteins
post_translational_modification
PTM: Probably phosphorylated by PLK1; may be required for degradation during mitosis. {ECO:0000269|PubMed:16439210}.; PTM: Ubiquitinated. Degradation during prophase is ubiquitin-dependent. {ECO:0000269|PubMed:16439210}.
uniprot
proteins
pubmed
16033705
uniprot
proteins
pubmed
16439210
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16764853
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19077034
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9618176
uniprot
proteins
sequence_length
810
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.
uniprot
proteins