LSR
entrez
51599
canonical
uniprot
Q86X29
canonical
ensembl
ENSG00000105699
resolver
ensp
ENSP00000346976
resolver
ensp
ENSP00000354034
resolver
ensp
ENSP00000354575
resolver
ensp
ENSP00000394479
resolver
ensp
ENSP00000472569
resolver
ensp
ENSP00000474797
resolver
ensp
ENSP00000533924
resolver
ensp
ENSP00000533925
resolver
ensp
ENSP00000533928
resolver
enst
ENST00000360798
resolver
enst
ENST00000361790
resolver
enst
ENST00000602122
resolver
enst
ENST00000605618
resolver
genesymbol
LSR
resolver
genesymbol_syn
ILDR3
resolver
genesymbol_syn
LISCH
resolver
hgnc
HGNC:29572
resolver
uniprot
A0A8Z5AA41
resolver
uniprot
A0A8Z5DL71
resolver
uniprot
A6NDW3
resolver
uniprot
B4DKL4
resolver
uniprot
E9PHD4
resolver
uniprot
O00112
resolver
uniprot
O00426
resolver
uniprot
Q6ZT80
resolver
uniprot
Q8NBM0
resolver
uniprot
Q9BT33
resolver
uniprot
Q9UQL3
resolver
uniprot
S4R3V8
resolver
uniprot_entry
A0A8Z5AA41_HUMAN
resolver
uniprot_entry
A0A8Z5DL71_HUMAN
resolver
uniprot_entry
LSR_HUMAN
resolver
uniprot_entry
S4R3V8_HUMAN
resolver
uniprot_sec
A6NDW3
resolver
uniprot_sec
B4DKL4
resolver
uniprot_sec
E9PHD4
resolver
uniprot_sec
O00112
resolver
uniprot_sec
O00426
resolver
uniprot_sec
Q6ZT80
resolver
uniprot_sec
Q8NBM0
resolver
uniprot_sec
Q9BT33
resolver
uniprot_sec
Q9UQL3
resolver
amino_acid_sequence
MQQDGLGVGTRNGSGKGRSVHPSWPWCAPRPLRYFGRDARARRAQTAAMALLAGGLSRGLGSHPAAAGRDAVVFVWLLLSTWCTAPARAIQVTVSNPYHVVILFQPVTLPCTYQMTSTPTQPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFDQTAWGDSGVYYCSVVSAQDLQGNNEAYAELIVLGRTSGVAELLPGFQAGPIEDWLFVVVVCLAAFLIFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSTYAHLSPAKTPPPPAMIPMGPAYNGYPGGYPGDVDRSSSAGGQGSYVPLLRDTDSSVASEVRSGYRIQASQQDDSMRVLYYMEKELANFDPSRPGPPSGRVERAMSEVTSLHEDDWRSRPSRGPALTPIRDEEWGGHSPRSPRGWDQEPAREQAGGGWRARRPRARSVDALDDLTPPSTAESGSRSPTSNGGRSRAYMPPRSRSRDDLYDQDDSRDFPRSRDPHYDDFRSRERPPADPRSHHHRTRDPRDNGSRSGDLPYDGRLLEEAVRKKGSEERRRPHKEEEEEAYYPPAPPPYSETDSQASRERRLKKNLALSRESLVV
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in LSR may be the cause of familial intrahepatic cholestasis. {ECO:0000269|PubMed:30250217}.
uniprot
proteins
function
FUNCTION: Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}.
uniprot
proteins
mass_dalton
71439
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-365 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions. {ECO:0000250|UniProtKB:Q99KG5}.; PTM: Polyubiquitinated at Lys-638 via 'Lys-63'-linked ubiquitin chains; deubiquitinated by USP53. {ECO:0000269|PubMed:39587316}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
LISCH7 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
17693683
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21245199
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23239027
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30250217
uniprot
proteins
pubmed
39587316
uniprot
proteins
sequence_length
649
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21245199}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:21245199, ECO:0000269|PubMed:23239027}. Note=Located at tricellular contacts. {ECO:0000269|PubMed:21245199}.
uniprot
proteins
transmembrane_region
TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins