Parl
entrez
381038
canonical
uniprot
Q5XJY4
canonical
ensembl
ENSMUSG00000033918
resolver
ensp
ENSMUSP00000045361
resolver
ensp
ENSMUSP00000155904
resolver
ensp
ENSMUSP00000186714
resolver
ensp
ENSMUSP00000186720
resolver
enst
ENSMUST00000048642
resolver
enst
ENSMUST00000152887
resolver
genesymbol
Parl
resolver
genesymbol_syn
Psarl
resolver
uniprot
A0A338P6A0
resolver
uniprot
Q3U9T5
resolver
uniprot
Q641T5
resolver
uniprot_entry
A0A338P6A0_MOUSE
resolver
uniprot_entry
PARL_MOUSE
resolver
uniprot_sec
Q3U9T5
resolver
uniprot_sec
Q641T5
resolver
amino_acid_sequence
MALQGWVQRGWRCGPAWAPPLGGGYRELSATQAPRLLGRRFNLFVQQKCGFRKAPRKVEPRRSDTGSSGEAYKRSALIPPLEETVFYPSPYPIRTLVKPFFFTIGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGNLRKEINKWWNSLSDGQRTVTGIIAANALVFCLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFVAVYLSAGVISNFVSYVCKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPVFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYITYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK
uniprot
proteins
ec_number
3.4.21.105
uniprot
proteins
function
FUNCTION: Required for the control of apoptosis during postnatal growth (PubMed:16839884). Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (PubMed:16839884). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (By similarity). Promotes cleavage of serine/threonine-protein phosphatase PGAM5 in damaged mitochondria in response to loss of mitochondrial membrane potential (By similarity). Mediates differential cleavage of PINK1 and PGAM5 depending on the health status of mitochondria, disassociating from PINK1 and associating with PGAM5 in response to mitochondrial membrane potential loss (By similarity). Required for processing of CLPB into a form with higher protein disaggregase activity by removing an autoinhibitory N-terminal peptide (By similarity). Promotes processing of DIABLO/SMAC in the mitochondrion which is required for DIABLO apoptotic activity (By similarity). Mediates STARD7 processing which regulates STARD7 location between mitochondria and cytosol (PubMed:36658222). Also required for cleavage of TTC19 (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity). {ECO:0000250|UniProtKB:Q9H300, ECO:0000269|PubMed:16839884, ECO:0000269|PubMed:36658222}.
uniprot
proteins
mass_dalton
41964
uniprot
proteins
post_translational_modification
PTM: P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner. {ECO:0000250}.
uniprot
proteins
protein_family
Peptidase S54 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16839884
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36658222
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:16839884}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H300}.; SUBCELLULAR LOCATION: [P-beta]: Nucleus {ECO:0000250|UniProtKB:Q9H300}. Note=Translocated into the nucleus by an unknown mechanism (By similarity). {ECO:0000250|UniProtKB:Q9H300}.
uniprot
proteins
transmembrane_region
TRANSMEM 100..119; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 166..185; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 206..228; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 243..260; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 271..287; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 294..316; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 331..352; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins