Exd2
entrez
97827
canonical
uniprot
Q8VEG4
canonical
ensembl
ENSMUSG00000032705
resolver
ensp
ENSMUSP00000043049
resolver
ensp
ENSMUSP00000305270
resolver
genesymbol
Exd2
resolver
genesymbol_syn
Exdl2
resolver
uniprot
F8WID1
resolver
uniprot
Q3TPJ5
resolver
uniprot
Q3TS84
resolver
uniprot_entry
EXD2_MOUSE
resolver
uniprot_sec
F8WID1
resolver
uniprot_sec
Q3TPJ5
resolver
uniprot_sec
Q3TS84
resolver
amino_acid_sequence
MSRQNLVALTVTTLLGVAMGGFVLWKGIQRRWSKTSRVMQQQPQQPQQPQQPQPQPQPQPQPQPEHPQPQQQVPGGREWPPPEDDQLPFGALRAPRASWEERILQAEVVTVSQEAEWNQIQPFLKRELEDFPVLGIDCEWVNLEGKASPLSLLQMASPSGFCALVRLPRLIYGGRTLPRTLLDILADGAILKVGVGCSEDANKLLQDYGLIVRGCLDLRYLAMKQGNNILCNGLSLKSLAETILNFPLDKSLLLRCSNWDAENLTEDQVTYAARDAQISVALFLHLLGYPFSRDSYEEESTDQINWQKALERCRNMVDIPFRSKGLGRLVEEVNGEALESQLKPRNRKAKTDRMVPGNNQGRDPRKHKRKPLGVGYSARKSPLYDNCFLQAPDGQPLCTCDRRKAQWYLDKGIGELVSKEPFVVRLQFEPAGRPESPGDYYLMVKENLCVVCGKTDTYIRKNIIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKEFQAPIGSEEGLRLLEDLERRQVRSGARALLNAESLPAHRKEELLHALREFYNTDIITEEMLHEAASLETRIYNESYIPHGLKVVQRHTEGGLRSLMQLESRWRQHFLDSMQPKHLPQQWSVDHNHQKLLRKYGDDLPIKLS
uniprot
proteins
ec_number
3.1.11.1
uniprot
proteins
ec_number
3.1.13.-
uniprot
proteins
function
FUNCTION: Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor. In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation. Also involved in the response to DNA damage. Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks. Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation. {ECO:0000250|UniProtKB:Q9NVH0}.
uniprot
proteins
mass_dalton
74332
uniprot
proteins
protein_family
EXD2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
650
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9NVH0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9NVH0, ECO:0000255}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q9NVH0}. Nucleus {ECO:0000250|UniProtKB:Q9NVH0}. Chromosome {ECO:0000250|UniProtKB:Q9NVH0}. Note=Mainly localizes to the mitochondrial outer membrane. May translocate to the nucleus in response to DNA damage; however mechanism that explain nuclear localization are unknown and require experimental evidence. Recruited to replication forks following replication stress. {ECO:0000250|UniProtKB:Q9NVH0}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..29; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins