Dlat
entrez
81654
canonical
uniprot
P08461
canonical
ensembl
ENSRNOG00000009994
resolver
ensembl
ENSRNOG00055028232
resolver
ensembl
ENSRNOG00060016068
resolver
ensembl
ENSRNOG00065017146
resolver
ensp
ENSRNOP00000103252
resolver
ensp
ENSRNOP00055040168
resolver
ensp
ENSRNOP00060022110
resolver
ensp
ENSRNOP00065022660
resolver
enst
ENSRNOT00000148798
resolver
enst
ENSRNOT00055048858
resolver
enst
ENSRNOT00060027521
resolver
enst
ENSRNOT00065028610
resolver
genesymbol
Dlat
resolver
uniprot
Q3B7V7
resolver
uniprot_entry
ODP2_RAT
resolver
uniprot_sec
Q3B7V7
resolver
amino_acid_sequence
MWRVCARRVQSAVPRAGFRARWATLKGPRTGPAAVRCGSGIPSYGVRSLCGWSYGSATVPRNRILQQLLGSPSRRSYSLPPHQKVPLPSLSPTMQAGTIARWEKKEGEKISEGDLIAEVETDKATVGFESLEECYMAKILVPEGTRDVPVGSIICITVEKPQDIEAFKNYTLDSATAATQAAPAPAAAPAAAPAAPSASAPGSSYPVHMQIVLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGTPLCIIVEKQEDIAAFADYRPTEVTSLKPQAPPPVPPPVAAVPPIPQPLAPTPSAAPAGPKGRVFVSPLAKKLAAEKGIDLTQVKGTGPEGRIIKKDIDSFVPTKAAPAAAAAAPPGPRVAPTPAGVFIDIPISNIRRVIAQRLMQSKQTIPHYYLSVDVNMGEVLLVRKELNKMLEGKGKISVNDFIIKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGLETIASDVVSLASKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLIPADNEKGFDVASVMSVTLSCDHRVVDGAVGAQWLAEFKKYLEKPVTMLL
uniprot
proteins
ec_number
2.3.1.12
uniprot
proteins
function
FUNCTION: The pyruvate dehydrogenase (PDH) complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3);. Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acetyl groups from acetyl-lipoyl moiety generated by the pyruvate dehydrogenase, leading to acetyl-CoA formation. {ECO:0000250|UniProtKB:P10515}.
uniprot
proteins
mass_dalton
67166
uniprot
proteins
post_translational_modification
PTM: Delipoylated at Lys-123 and Lys-249 by SIRT4, delipoylation decreases the PHD complex activity. {ECO:0000250|UniProtKB:P10515}.
uniprot
proteins
protein_family
2-oxoacid dehydrogenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1581353
uniprot
proteins
pubmed
19423663
uniprot
proteins
pubmed
3571977
uniprot
proteins
sequence_length
632
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305|PubMed:3571977}.
uniprot
proteins