FCHO2
entrez
115548
canonical
uniprot
Q0JRZ9
canonical
ensembl
ENSG00000157107
resolver
ensp
ENSP00000393776
resolver
ensp
ENSP00000427296
resolver
ensp
ENSP00000626708
resolver
ensp
ENSP00000653475
resolver
ensp
ENSP00000683922
resolver
ensp
ENSP00000782254
resolver
genesymbol
FCHO2
resolver
hgnc
HGNC:25180
resolver
uniprot
A8K6W7
resolver
uniprot
B2RNQ9
resolver
uniprot
B4DHK0
resolver
uniprot
E9PG79
resolver
uniprot
Q0JTJ3
resolver
uniprot
Q96CF5
resolver
uniprot_entry
FCHO2_HUMAN
resolver
uniprot_sec
A8K6W7
resolver
uniprot_sec
B2RNQ9
resolver
uniprot_sec
B4DHK0
resolver
uniprot_sec
E9PG79
resolver
uniprot_sec
Q0JTJ3
resolver
uniprot_sec
Q96CF5
resolver
amino_acid_sequence
MVMAYFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVAGTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKKATDTYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNAIKEIHLQIGQVHEEFINNMANTTVESLIQKFAESKGTGKERPGLIEFEECDTASAVEGIKPRKRKTFALPGIIKKEKDAESVECPDADSLNIPDVDEEGYSIKPETNQNDTKENHFYSSSDSDSEDEEPKKYRIEIKPMHPNNSHHTMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTKSKPSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPTKCIVKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKNISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLATYWKCSASTTDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSSISEKSENGGSGSLRAKFDLSEGPSKPTTLAVQFLSEGSTLSGVDFELVGTGYRLSLIKKRFATGRYLADC
uniprot
proteins
function
FUNCTION: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}.
uniprot
proteins
mass_dalton
88924
uniprot
proteins
mutagenesis
MUTAGEN 10; /note="F->E: Binds preferentially to larger liposomes."; /evidence="ECO:0000269|PubMed:17540576
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Mainly undergoes monoubiquitination but also polyubiquitination (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
FCHO family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17540576
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20448150
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21762413
uniprot
proteins
pubmed
22323290
uniprot
proteins
pubmed
22484487
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
810
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane, clathrin-coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). {ECO:0000250}.
uniprot
proteins