Stk33
entrez
117229
canonical
uniprot
Q924X7
canonical
ensembl
ENSMUSG00000031027
resolver
ensp
ENSMUSP00000087897
resolver
ensp
ENSMUSP00000102356
resolver
ensp
ENSMUSP00000112515
resolver
ensp
ENSMUSP00000112560
resolver
ensp
ENSMUSP00000162575
resolver
ensp
ENSMUSP00000162576
resolver
ensp
ENSMUSP00000353048
resolver
enst
ENSMUST00000090414
resolver
enst
ENSMUST00000106745
resolver
enst
ENSMUST00000121378
resolver
enst
ENSMUST00000121748
resolver
genesymbol
Stk33
resolver
uniprot
D3YWA6
resolver
uniprot
Q4A1D4
resolver
uniprot_entry
D3YWA6_MOUSE
resolver
uniprot_entry
STK33_MOUSE
resolver
uniprot_sec
Q4A1D4
resolver
activity_regulation
ACTIVITY REGULATION: Specifically inhibited by CDD-2807 ((3-([1,1'-Biphenyl]-2-ylethynyl)-1H-indazol-5-yl)(2,6-diazaspiro[3.5]nonan-2-yl)methanone) (PubMed:38781365). CDD-2807 is a potential male contraceptive drug: it is not toxic, efficiently crosses the blood-testis barrier and induces a reversible contraceptive effect in male mice (PubMed:38781365). {ECO:0000269|PubMed:38781365}.
uniprot
proteins
amino_acid_sequence
MADPSLNDNPTACPHCASSQAGLLCVCPAGKSPVLVVEMSQTSSIGSTEFFASQERKKERNTSRESSLKDLSIRTSNVERKPQAQWSRSNVTVGKIPHIRMDDGAGIEEFYTFGRILGQGSFGMVFEAIDKETGAKWAIKKVNKEKAGSSAMKLLEREVSILKTVNHQHIIHLEQVFESPQKMYLVMELCEDGELKAVMDQRGHFSENETRLIIQSLASAIAYLHNKDIVHRDLKLENIMVKSSFIDDNNEMNLNIKVTDFGLSVQKHGSRSEGMMQTTCGTPIYMAPEVINAHDYSQQCDIWSIGVIMFILLCGEPPFLANSEEKLYELIKKGELRFENPVWESVSDSAKNTLKQLMKVDPAHRITAKELLDNQWLTGNTLSSARPTNVLEMMKEWKNNPESDEETNTDEETEQSAVYSPSANTAKQPTNAAKKPAAESVGMTSSNSSSSKLLSAESKAEPEKSSETVGHASVAKTTLKSTTLFRGKKRL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:29155043, PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (PubMed:37146716). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (PubMed:18811945). {ECO:0000269|PubMed:18811945, ECO:0000269|PubMed:29155043, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}.
uniprot
proteins
mass_dalton
54459
uniprot
proteins
mutagenesis
MUTAGEN 140; /note="K->M: Abolished serine/threonine protein kinase activity."; /evidence="ECO:0000269|PubMed:37146716"; MUTAGEN 460..491; /note="Missing: Knockin mice show male subfertility with decreased count and motility of sperm."; /evidence="ECO:0000269|PubMed:37146716
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000269|PubMed:18811945}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11528127
uniprot
proteins
pubmed
11738831
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16176263
uniprot
proteins
pubmed
18811945
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29155043
uniprot
proteins
pubmed
37146716
uniprot
proteins
pubmed
38781365
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29155043}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:29155043}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16176263}. Note=Colocalizes with the caudal end of the manchette, a transient structure that guides tail elongation in elongating spermatids. {ECO:0000269|PubMed:29155043}.
uniprot
proteins