RNASEK
entrez
440400
canonical
uniprot
Q6P5S7
canonical
ensembl
ENSG00000219200
resolver
ensp
ENSP00000468923
resolver
enst
ENST00000593646
resolver
genesymbol
RNASEK
resolver
hgnc
HGNC:33911
resolver
uniprot
A0A0C4DH89
resolver
uniprot
G3V1Z9
resolver
uniprot
Q502Z2
resolver
uniprot_entry
A0A0C4DH89_HUMAN
resolver
uniprot_entry
RNK_HUMAN
resolver
uniprot_sec
G3V1Z9
resolver
uniprot_sec
Q502Z2
resolver
amino_acid_sequence
MGWLRPGPRPLCPPARASWAFSHRFPSPLAPRRSPTPFFMASLLCCGPKLAACGIVLSAWGVIMLIMLGIFFNVHSAVLIEDVPFTEKDFENGPQNIYNLYEQVSYNCFIAAGLYLLLGGFSFCQVRLNKRKEYMVR
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate (PubMed:17881363). Regulates the activity of vacuolar (H+)-ATPase (V-ATPase) which is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:26212330). Required at an early stage of receptor-mediated endocytosis (PubMed:26212330). {ECO:0000269|PubMed:17881363, ECO:0000269|PubMed:26212330}.; FUNCTION: (Microbial infection) Required at an early stage of both clathrin-mediated and clathrin-independent endocytic uptake of a diverse set of viruses, including dengue, West Nile, Sindbis, Rift Valley Fever, influenza, and human rhinoviruses (PubMed:26056282, PubMed:26212330). {ECO:0000269|PubMed:26056282, ECO:0000269|PubMed:26212330}.
uniprot
proteins
mass_dalton
15420
uniprot
proteins
protein_family
RNase K family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17881363
uniprot
proteins
pubmed
26056282
uniprot
proteins
pubmed
26212330
uniprot
proteins
pubmed
33065002
uniprot
proteins
sequence_length
137
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:26212330}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q3ZC23}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins