Ddhd1
entrez
114874
canonical
uniprot
Q80YA3
canonical
ensembl
ENSMUSG00000037697
resolver
ensp
ENSMUSP00000050088
resolver
ensp
ENSMUSP00000084577
resolver
ensp
ENSMUSP00000107459
resolver
enst
ENSMUST00000051310
resolver
enst
ENSMUST00000087320
resolver
enst
ENSMUST00000111828
resolver
genesymbol
Ddhd1
resolver
uniprot
E9QQ38
resolver
uniprot
F8WHP5
resolver
uniprot
F8WIJ5
resolver
uniprot
Q8VEF2
resolver
uniprot_entry
DDHD1_MOUSE
resolver
uniprot_entry
E9QQ38_MOUSE
resolver
uniprot_entry
F8WHP5_MOUSE
resolver
uniprot_entry
F8WIJ5_MOUSE
resolver
uniprot_sec
Q8VEF2
resolver
amino_acid_sequence
MDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTSHIVFVVHGIGQKMDQGRIIKNTAMMREAARKMEEKHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPDFEEKGGKVSIVSHSLGCVITYDIMMGWNPGGLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLREIEDRLHGLKAPSISQTPALKFKVENFFCMGSPLAVFLALRGIRPGNSGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEHMKPNFLNPAKEPTSVSDSENIAAIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSASQPSEPSKDSLEDDKKPSASPSTTTVATQTLPHSGSGFLDSAYFRLQESFFYLPQLLFPENVMQSKDDSLVELEHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDTEAKPSLGSL
uniprot
proteins
ec_number
3.1.1.111
uniprot
proteins
ec_number
3.1.1.118
uniprot
proteins
ec_number
3.1.1.32
uniprot
proteins
function
FUNCTION: Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:30221923). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:30221923). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system (PubMed:30221923). Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (PubMed:30221923). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q8NEL9, ECO:0000269|PubMed:24599962, ECO:0000269|PubMed:30221923, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}.
uniprot
proteins
mass_dalton
61823
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylinositol metabolism. {ECO:0000305|PubMed:37189713}.
uniprot
proteins
protein_family
PA-PLA1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24599962
uniprot
proteins
pubmed
30221923
uniprot
proteins
pubmed
37189713
uniprot
proteins
pubmed
37832604
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8NEL9}.
uniprot
proteins