Kpna2
entrez
16647
canonical
uniprot
P52293
canonical
ensembl
ENSMUSG00000018362
resolver
ensembl
ENSMUSG00000066878
resolver
ensp
ENSMUSP00000018506
resolver
ensp
ENSMUSP00000137310
resolver
enst
ENSMUST00000018506
resolver
enst
ENSMUST00000086423
resolver
genesymbol
Kpna2
resolver
genesymbol_syn
Rch1
resolver
uniprot
Q52L97
resolver
uniprot
Q64292
resolver
uniprot_entry
IMA1_MOUSE
resolver
uniprot_entry
Q52L97_MOUSE
resolver
uniprot_sec
Q64292
resolver
amino_acid_sequence
MSTNENANLPAARLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDEQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHENESVYKASLNLIEKYFSVEEEEDQNVVPETTSEGFAFQVQDGAPGTFNF
uniprot
proteins
function
FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:21690087). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:21690087). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (By similarity). {ECO:0000250|UniProtKB:P52292, ECO:0000269|PubMed:21690087}.
uniprot
proteins
mass_dalton
57928
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Deubiquitinated by USP22; leading to stabilization and increased activity. {ECO:0000250|UniProtKB:P52292}.
uniprot
proteins
protein_family
Importin alpha family
uniprot
proteins
pubmed
10201409
uniprot
proteins
pubmed
10692581
uniprot
proteins
pubmed
10764582
uniprot
proteins
pubmed
11448961
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16222336
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21454664
uniprot
proteins
pubmed
21690087
uniprot
proteins
pubmed
26689472
uniprot
proteins
pubmed
7565597
uniprot
proteins
pubmed
7641681
uniprot
proteins
pubmed
8631802
uniprot
proteins
sequence_length
529
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P52292}. Nucleus {ECO:0000250|UniProtKB:P52292}.
uniprot
proteins