TRIM16
entrez
10626
canonical
uniprot
O95361
canonical
ensembl
ENSG00000221926
resolver
ensp
ENSP00000338989
resolver
ensp
ENSP00000399918
resolver
ensp
ENSP00000462903
resolver
ensp
ENSP00000497185
resolver
ensp
ENSP00000637608
resolver
enst
ENST00000416464
resolver
genesymbol
TRIM16
resolver
genesymbol_syn
EBBP
resolver
hgnc
HGNC:17241
resolver
uniprot
B3KP96
resolver
uniprot
F6WTG8
resolver
uniprot
Q6IAL8
resolver
uniprot
Q7Z6I2
resolver
uniprot
Q96BE8
resolver
uniprot
Q96J43
resolver
uniprot_entry
B3KP96_HUMAN
resolver
uniprot_entry
F6WTG8_HUMAN
resolver
uniprot_entry
TRI16_HUMAN
resolver
uniprot_sec
Q6IAL8
resolver
uniprot_sec
Q7Z6I2
resolver
uniprot_sec
Q96BE8
resolver
uniprot_sec
Q96J43
resolver
amino_acid_sequence
MAELDLMAPGPLPRATAQPPAPLSPDSGSPSPDSGSASPVEEEDVGSSEKLGRETEEQDSDSAEQGDPAGEGKEVLCDFCLDDTRRVKAVKSCLTCMVNYCEEHLQPHQVNIKLQSHLLTEPVKDHNWRYCPAHHSPLSAFCCPDQQCICQDCCQEHSGHTIVSLDAARRDKEAELQCTQLDLERKLKLNENAISRLQANQKSVLVSVSEVKAVAEMQFGELLAAVRKAQANVMLFLEEKEQAALSQANGIKAHLEYRSAEMEKSKQELERMAAISNTVQFLEEYCKFKNTEDITFPSVYVGLKDKLSGIRKVITESTVHLIQLLENYKKKLQEFSKEEEYDIRTQVSAVVQRKYWTSKPEPSTREQFLQYAYDITFDPDTAHKYLRLQEENRKVTNTTPWEHPYPDLPSRFLHWRQVLSQQSLYLHRYYFEVEIFGAGTYVGLTCKGIDRKGEERNSCISGNNFSWSLQWNGKEFTAWYSDMETPLKAGPFRRLGVYIDFPGGILSFYGVEYDTMTLVHKFACKFSEPVYAAFWLSKKENAIRIVDLGEEPEKPAPSLVGTAP
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages (PubMed:22629402, PubMed:27693506). Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2 (PubMed:30143514). Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000269|PubMed:22629402, ECO:0000269|PubMed:27693506, ECO:0000269|PubMed:30143514}.
uniprot
proteins
mass_dalton
63955
uniprot
proteins
mutagenesis
MUTAGEN 116; /note="S->A: Loss of protection from cell death during oxidative stress; when associated with A-203."; /evidence="ECO:0000269|PubMed:27693506"; MUTAGEN 203; /note="S->A: Loss of protection from cell death during oxidative stress; when associated with A-116."; /evidence="ECO:0000269|PubMed:27693506
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ULK1. {ECO:0000269|PubMed:27693506}.; PTM: Auto-ubiquitinates via its B-Boxes. {ECO:0000269|PubMed:22629402}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11919186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22629402
uniprot
proteins
pubmed
27693506
uniprot
proteins
pubmed
30143514
uniprot
proteins
pubmed
40821731
uniprot
proteins
pubmed
9817599
uniprot
proteins
sequence_length
564
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27693506}.
uniprot
proteins