KCTD21
entrez
283219
canonical
uniprot
Q4G0X4
canonical
ensembl
ENSG00000188997
resolver
ensp
ENSP00000339340
resolver
ensp
ENSP00000578738
resolver
ensp
ENSP00000578739
resolver
ensp
ENSP00000578740
resolver
ensp
ENSP00000578741
resolver
ensp
ENSP00000590415
resolver
ensp
ENSP00000611280
resolver
ensp
ENSP00000611281
resolver
enst
ENST00000340067
resolver
enst
ENST00000908679
resolver
enst
ENST00000908680
resolver
enst
ENST00000908681
resolver
enst
ENST00000908682
resolver
enst
ENST00000920356
resolver
enst
ENST00000941221
resolver
enst
ENST00000941222
resolver
genesymbol
KCTD21
resolver
hgnc
HGNC:27452
resolver
uniprot
B4DTR0
resolver
uniprot_entry
KCD21_HUMAN
resolver
uniprot_sec
B4DTR0
resolver
amino_acid_sequence
MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPLIEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTSCLFLKLLGSKLFYCSNGNLSSITSHLQDPNHLTLDWVANVEGLPEEEYTKQNLKRLWVVPANKQINSFQVFVEEVLKIALSDGFCIDSSHPHALDFMNNKIIRLIRYR
uniprot
proteins
function
FUNCTION: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). {ECO:0000269|PubMed:21472142}.
uniprot
proteins
mass_dalton
29643
uniprot
proteins
mutagenesis
MUTAGEN 85..87; /note="DFY->KKK: Abolishes interaction with CUL3."; /evidence="ECO:0000269|PubMed:21472142
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21472142
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
260
uniprot
proteins