Map6
entrez
17760
canonical
uniprot
Q7TSJ2
canonical
ensembl
ENSMUSG00000055407
resolver
ensp
ENSMUSP00000146340
resolver
ensp
ENSMUSP00000146585
resolver
ensp
ENSMUSP00000146897
resolver
genesymbol
Map6
resolver
genesymbol_syn
Mtap6
resolver
uniprot
O55129
resolver
uniprot
O70586
resolver
uniprot
O70587
resolver
uniprot
Q78DV4
resolver
uniprot
Q78DV5
resolver
uniprot_entry
MAP6_MOUSE
resolver
uniprot_sec
O55129
resolver
uniprot_sec
O70586
resolver
uniprot_sec
O70587
resolver
uniprot_sec
Q78DV4
resolver
uniprot_sec
Q78DV5
resolver
amino_acid_sequence
MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPAPLQPALAPPSRAVAIETQPAQGESDAVARATGPAPGPSVDRETVAAPGRSGLGLGAASASTSGSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQIPATSQPSQPVLGVPKRRPQSQERGPMQLSADARDPEGAGGAGVLAAGKASGVDQRDTRRKAGPAWMVTRNEGHEEKPLPPAQSQTQEGGPAAGKASGADQRDTRRKAGPAWMVTRSEGHEEKPLPPAQSQTQEGGPAAGKASGADQRDTRRKAGPAWMVTRTEGHEETPLPPAQSQTQEGGPAAGKASGADERDTRRKAGPAWMVRRSEGHEQTPAAHAQGTGPEGGKGRAVADALNRQIREEVASTVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEANKPSAADNKAMDRRRIRSLYSEPFKECPKVEKPSVQSSKPKKTSTSHKPPRKAKDKQVVSGQAAKKKTTEGPSATKPDDKEQSKEMNNKLAEAKESRVKPTSDASKNRGPVTKEPHKDQGSVAPGLPKGQEPLKDQGPVVPGLPKDQVPVVPGSLKGQSPTAPGPTKDQGAVLLGPVKDLGPVAPAPIKVQDHIASELLKNKDSVPLAPAKAQSPLLPEPLKNQSPVVPASTKDQSFPTPAPRKDPGPVIPEPEKDRAPTVPERRKDQHVSIMASLKNEAPMVPESVKNQGLAGPELVKDTGTDTTAPRYLKGHDSVFVAPVKNQGPVIPEPVKSQDPIIPALAKDQGPMLPEPPKNQSPVVLGPIKNQDPIIPVPLKGQDPLVPAPTKDQGPTAPDPLKTQGPKGTQLPTVSPSPPVMIPTVPHTEYIEGSP
uniprot
proteins
function
FUNCTION: Involved in microtubule stabilization in many cell types, including neuronal cells (PubMed:9600916). Specifically has microtubule cold stabilizing activity (PubMed:9600916). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (By similarity). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (PubMed:28521134). {ECO:0000250|UniProtKB:Q63560, ECO:0000250|UniProtKB:Q96JE9, ECO:0000269|PubMed:28521134, ECO:0000269|PubMed:9600916}.
uniprot
proteins
mass_dalton
96450
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Probably depalmitoylated by ABHD17A, ABHD17B and ABHD17C. During neuronal polarization, palmitoylation and depalmitoylation cycles regulate MAP6 shuttling between secretory vesicles and microtubules, and its polarized distribution in the axon. {ECO:0000250|UniProtKB:Q63560}.
uniprot
proteins
protein_family
STOP family
uniprot
proteins
pubmed
12231625
uniprot
proteins
pubmed
12782132
uniprot
proteins
pubmed
14516200
uniprot
proteins
pubmed
15389836
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16837464
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
26198635
uniprot
proteins
pubmed
28521134
uniprot
proteins
pubmed
9501006
uniprot
proteins
pubmed
9600916
uniprot
proteins
sequence_length
906
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9600916}. Golgi apparatus {ECO:0000269|PubMed:16837464}. Cell projection, axon {ECO:0000250|UniProtKB:Q63560}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63560}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q63560}; Lipid-anchor {ECO:0000250|UniProtKB:Q63560}; Cytoplasmic side {ECO:0000250|UniProtKB:Q63560}. Note=Isoform 1 and isoform 2 associate with axonal microtubules in neurons (PubMed:16837464). Isoform 3 associates with microtubules in fibroblasts (PubMed:9600916). Localizes predominantly in the proximal part of the axon (By similarity). Preferentially is concentrated on a portion of the microtubule polymer in which tubulin is modified by detyrosination and acetylation and is also resistant to depolymerization induced by both nocodazole and cold (By similarity). In unpolarized neurons, localizes to the Golgi and to secretory vesicles accumulating transiently at the tips of a subset of neurites (By similarity). Following neuronal polarization and during axon outgrowth, accumulates in the axonal growth cone and subsequently localizes throughout the axon. Partially localizes to dendrites in mature neurons (By similarity). {ECO:0000250|UniProtKB:Q63560, ECO:0000269|PubMed:16837464, ECO:0000269|PubMed:9600916}.
uniprot
proteins