FZD7
entrez
8324
canonical
uniprot
O75084
canonical
ensembl
ENSG00000155760
resolver
ensp
ENSP00000286201
resolver
enst
ENST00000286201
resolver
genesymbol
FZD7
resolver
hgnc
HGNC:4045
resolver
uniprot
O94816
resolver
uniprot
Q53S59
resolver
uniprot
Q96B74
resolver
uniprot_entry
FZD7_HUMAN
resolver
uniprot_sec
O94816
resolver
uniprot_sec
Q53S59
resolver
uniprot_sec
Q96B74
resolver
amino_acid_sequence
MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity). Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G proteins by CCDC88C and triggering of non-canonical Wnt responses (PubMed:26126266). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. {ECO:0000250|UniProtKB:Q61090, ECO:0000269|PubMed:26126266}.; FUNCTION: (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium. {ECO:0000269|PubMed:27680706}.
uniprot
proteins
mass_dalton
63620
uniprot
proteins
mutagenesis
MUTAGEN 569; /note="K->A: Impaired SDCBP-mediated interaction with phosphatidylinositol-4,5-bisphosphate."; /evidence="ECO:0000269|PubMed:27386966
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17224074
uniprot
proteins
pubmed
19188438
uniprot
proteins
pubmed
24496449
uniprot
proteins
pubmed
26126266
uniprot
proteins
pubmed
27386966
uniprot
proteins
pubmed
27680706
uniprot
proteins
pubmed
9707618
uniprot
proteins
pubmed
9813155
uniprot
proteins
sequence_length
574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27386966}; Multi-pass membrane protein {ECO:0000269|PubMed:27386966}. Endosome membrane {ECO:0000269|PubMed:27386966}; Multi-pass membrane protein {ECO:0000269|PubMed:27386966}. Note=Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions. {ECO:0000269|PubMed:27386966}.
uniprot
proteins
transmembrane_region
TRANSMEM 257..277; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 337..357; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 380..400; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 424..444; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 471..491; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 529..549; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins