DEDD
entrez
9191
canonical
uniprot
O75618
canonical
ensembl
ENSG00000158796
resolver
ensp
ENSP00000356984
resolver
ensp
ENSP00000356985
resolver
ensp
ENSP00000414821
resolver
ensp
ENSP00000445835
resolver
ensp
ENSP00000535174
resolver
ensp
ENSP00000613126
resolver
enst
ENST00000368005
resolver
enst
ENST00000865115
resolver
enst
ENST00000943067
resolver
genesymbol
DEDD
resolver
genesymbol_syn
DEDPRO1
resolver
genesymbol_syn
DEFT
resolver
hgnc
HGNC:2755
resolver
uniprot
B1AQP5
resolver
uniprot
D3DVF5
resolver
uniprot
O60737
resolver
uniprot_entry
B1AQP5_HUMAN
resolver
uniprot_entry
DEDD_HUMAN
resolver
uniprot_sec
D3DVF5
resolver
uniprot_sec
O60737
resolver
amino_acid_sequence
MAGLKRRASQVWPEEHGEQEHGLYSLHRMFDIVGTHLTHRDVRVLSFLFVDVIDDHERGLIRNGRDFLLALERQGRCDESNFRQVLQLLRIITRHDLLPYVTLKRRRAVCPDLVDKYLEETSIRYVTPRALSDPEPRPPQPSKTVPPHYPVVCCPTSGPQMCSKRPARGRATLGSQRKRRKSVTPDPKEKQTCDIRLRVRAEYCQHETALQGNVFSNKQDPLERQFERFNQANTILKSRDLGSIICDIKFSELTYLDAFWRDYINGSLLEALKGVFITDSLKQAVGHEAIKLLVNVDEEDYELGRQKLLRNLMLQALP
uniprot
proteins
function
FUNCTION: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity). {ECO:0000250, ECO:0000269|PubMed:12235123}.
uniprot
proteins
mass_dalton
36794
uniprot
proteins
post_translational_modification
PTM: Exists predominantly in a mono- or diubiquitinated form.
uniprot
proteins
pubmed
11965497
uniprot
proteins
pubmed
12235123
uniprot
proteins
pubmed
12527898
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
9774341
uniprot
proteins
pubmed
9832420
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus {ECO:0000250}. Note=Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells. {ECO:0000250}.
uniprot
proteins