Pnoc
entrez
18155
canonical
uniprot
Q64387
canonical
ensembl
ENSMUSG00000045731
resolver
ensp
ENSMUSP00000054210
resolver
ensp
ENSMUSP00000153589
resolver
ensp
ENSMUSP00000246561
resolver
ensp
ENSMUSP00000246562
resolver
genesymbol
Pnoc
resolver
genesymbol_syn
Npnc1
resolver
uniprot
B7ZMX9
resolver
uniprot
Q543U6
resolver
uniprot
Q61105
resolver
uniprot
Q61938
resolver
uniprot_entry
B7ZMX9_MOUSE
resolver
uniprot_entry
PNOC_MOUSE
resolver
uniprot_entry
Q543U6_MOUSE
resolver
uniprot_sec
Q61105
resolver
uniprot_sec
Q61938
resolver
amino_acid_sequence
MKILFCDVLLLSLLSSVFSSCPRDCLTCQEKLHPAPDSFNLKTCILQCEEKVFPRPLWTVCTKVMASGSGQLSPADPELVSAALYQPKASEMQHLKRMPRVRSLVQVRDAEPGADAEPGADAEPGADDAEEVEQKQLQKRFGGFTGARKSARKLANQKRFSEFMRQYLVLSMQSSQRRRTLHQNGNV
uniprot
proteins
function
FUNCTION: [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. When administered intracerebroventricularly, nociceptin induces hyperalgesia and decreases locomotor activity.; FUNCTION: [Nocistatin]: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia. {ECO:0000250|UniProtKB:O62647}.; FUNCTION: [Orphanin FQ2]: Has potent analgesic activity. {ECO:0000269|PubMed:9601687}.
uniprot
proteins
mass_dalton
20884
uniprot
proteins
post_translational_modification
PTM: Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.; PTM: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
uniprot
proteins
protein_family
Opioid neuropeptide precursor family
uniprot
proteins
pubmed
7503733
uniprot
proteins
pubmed
8645247
uniprot
proteins
pubmed
8663129
uniprot
proteins
pubmed
8670093
uniprot
proteins
pubmed
8710928
uniprot
proteins
pubmed
9601687
uniprot
proteins
sequence_length
187
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins