Fam20b
entrez
215015
canonical
uniprot
Q8VCS3
canonical
ensembl
ENSMUSG00000033557
resolver
ensp
ENSMUSP00000083322
resolver
ensp
ENSMUSP00000112534
resolver
ensp
ENSMUSP00000229879
resolver
ensp
ENSMUSP00000229893
resolver
ensp
ENSMUSP00000229895
resolver
enst
ENSMUST00000086153
resolver
enst
ENSMUST00000122424
resolver
genesymbol
Fam20b
resolver
uniprot
Q3V201
resolver
uniprot
Q6ZQA3
resolver
uniprot
Q8BWX2
resolver
uniprot_entry
XYLK_MOUSE
resolver
uniprot_sec
Q3V201
resolver
uniprot_sec
Q6ZQA3
resolver
uniprot_sec
Q8BWX2
resolver
amino_acid_sequence
MKLKQRVVLLAILLVIFIFTKVFLIDNLDTSAANREDQRAFHRMMTGLRVELVPKLDHTLQSPWEIAAQWVVPREVYPEETPELGAIMHAMATKKIIKADVGYKGTQLKALLILEGGQKVVFKPKRYSRDYVVEGEPYAGYDRHNAEVAAFHLDRILGFRRAPLVVGRYVNLRTEVKPVATEQLLSTFLTVGNNTCFYGKCYYCRETEPACADGDMMEGSVTLWLPDVWPLQKHRHPWGRTYREGKLARWEYDESYCDAVKKTSPYDSGPRLLDIIDTAVFDYLIGNADRHHYESFQDDEGASMLILLDNAKSFGNPSLDERSILAPLYQCCIIRVSTWNRLNYLKNGVLKSALKSAMAHDPISPVLSDPHLDTVDQRLLNVLATIKQCTDQFGTDTVLVEDRMPLSHL
uniprot
proteins
ec_number
2.7.1.-
uniprot
proteins
function
FUNCTION: Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized. {ECO:0000250|UniProtKB:O75063}.
uniprot
proteins
mass_dalton
46581
uniprot
proteins
protein_family
FAM20 family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21549343
uniprot
proteins
pubmed
22732358
uniprot
proteins
pubmed
22900076
uniprot
proteins
sequence_length
409
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:22900076}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..25; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins