DCPH1
entrez
79624
canonical
uniprot
Q9H993
canonical
ensembl
ENSG00000146476
resolver
ensp
ENSP00000356263
resolver
ensp
ENSP00000444121
resolver
enst
ENST00000367294
resolver
enst
ENST00000545879
resolver
genesymbol
DCPH1
resolver
genesymbol_syn
ARMT1
resolver
genesymbol_syn
C6orf211
resolver
genesymbol_syn
DUF89
resolver
hgnc
HGNC:17872
resolver
uniprot
B4DPT6
resolver
uniprot
F5GZY1
resolver
uniprot
Q96FC6
resolver
uniprot
Q9UFY5
resolver
uniprot_entry
ARMT1_HUMAN
resolver
uniprot_entry
B4DPT6_HUMAN
resolver
uniprot_entry
F5GZY1_HUMAN
resolver
uniprot_sec
Q96FC6
resolver
uniprot_sec
Q9UFY5
resolver
amino_acid_sequence
MAVVPASLSGQDVGSFAYLTIKDRIPQILTKVIDTLHRHKSEFFEKHGEEGVEAEKKAISLLSKLRNELQTDKPFIPLVEKFVDTDIWNQYLEYQQSLLNESDGKSRWFYSPWLLVECYMYRRIHEAIIQSPPIDYFDVFKESKEQNFYGSQESIIALCTHLQQLIRTIEDLDENQLKDEFFKLLQISLWGNKCDLSLSGGESSSQNTNVLNSLEDLKPFILLNDMEHLWSLLSNCKKTREKASATRVYIVLDNSGFELVTDLILADFLLSSELATEVHFYGKTIPWFVSDTTIHDFNWLIEQVKHSNHKWMSKCGADWEEYIKMGKWVYHNHIFWTLPHEYCAMPQVAPDLYAELQKAHLILFKGDLNYRKLTGDRKWEFSVPFHQALNGFHPAPLCTIRTLKAEIQVGLQPGQGEQLLASEPSWWTTGKYGIFQYDGPL
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
function
FUNCTION: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (PubMed:32682077). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (PubMed:32682077). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (PubMed:25732820). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (PubMed:25732820). {ECO:0000269|PubMed:25732820, ECO:0000269|PubMed:32682077}.
uniprot
proteins
mass_dalton
51172
uniprot
proteins
mutagenesis
MUTAGEN 291; /note="D->A: No Mn(2+)-binding. Loss of phosphatase activity."; /evidence="ECO:0000269|PubMed:32682077
uniprot
proteins
post_translational_modification
PTM: Automethylated. {ECO:0000305|PubMed:25732820}.
uniprot
proteins
protein_family
Damage-control phosphatase family
uniprot
proteins
protein_family
Sugar phosphate phosphatase III subfamily
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25732820
uniprot
proteins
pubmed
27322068
uniprot
proteins
pubmed
32682077
uniprot
proteins
sequence_length
441
uniprot
proteins