Ihh
entrez
16147
canonical
uniprot
P97812
canonical
ensembl
ENSMUSG00000006538
resolver
ensp
ENSMUSP00000128056
resolver
enst
ENSMUST00000164097
resolver
genesymbol
Ihh
resolver
uniprot
Q61724
resolver
uniprot
Q80XI9
resolver
uniprot_entry
IHH_MOUSE
resolver
uniprot_entry
Q80XI9_MOUSE
resolver
uniprot_sec
Q61724
resolver
amino_acid_sequence
MSPAWLRPRLRFCLFLLLLLLVPAARGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTGGCFPAGAQVRLENGERVALSAVKPGDRVLAMGEDGTPTFSDVLIFLDREPNRLRAFQVIETQDPPRRLALTPAHLLFIADNHTEPAAHFRATFASHVQPGQYVLVSGVPGLQPARVAAVSTHVALGSYAPLTRHGTLVVEDVVASCFAAVADHHLAQLAFWPLRLFPSLAWGSWTPSEGVHWYPQMLYRLGRLLLEESTFHPLGMSGAGS
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: [Indian hedgehog protein]: Precursor of indian hedgehog, a morphogen that activates the smoothened signaling pathway, and which is essential for bone and cartilage development (PubMed:10465785, PubMed:10631175, PubMed:18582859, PubMed:19252479). The C-terminal part of the precursor displays an autoproteolysis and a cholesterol transferase activity, resulting (1) in the cleavage of the full-length protein into two parts, indian hedgehog protein N-product and C-product and (2) covalent attachment of a cholesterol moiety to the C-terminus of the newly generated N-product (By similarity). Both autoproteolysis and a cholesterol transferase activities occur in the endoplasmic reticulum (By similarity). Following additional lipidation, N-product acts as a morphogen, while C-product is degraded in the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q62226, ECO:0000269|PubMed:10465785, ECO:0000269|PubMed:10631175, ECO:0000269|PubMed:18582859, ECO:0000269|PubMed:19252479}.; FUNCTION: [Indian hedgehog protein N-product]: The dually lipidated indian hedgehog protein N-product is a morphogen that activates the smoothened signaling pathway, and which is essential for bone and cartilage development (PubMed:10465785, PubMed:10631175, PubMed:19252479). Acts by binding to the patched receptor (PTCH1 or PTCH2), relieving smoothened (SMO) inhibition by patched, activating the smoothened signaling pathway and transcription of target genes (PubMed:19252479). In the absence of IHH, patched represses the constitutive signaling activity of SMO (By similarity). Plays a role in morphogenesis of the skeleton by coordinating growth and differentiation of the endochondral skeleton (PubMed:10465785, PubMed:10631175, PubMed:19252479). Positively regulates PTHLH expression during endochondral bone formation preventing chondrocyte hypertrophy (PubMed:10465785, PubMed:10631175). In contrast, participates in normal chondrocyte proliferation in a PTHLH-independent pathway (PubMed:10631175). Involved in the development of retinal pigment epithelium (RPE), photoreceptors and periocular tissues (PubMed:18582859). Plays a role in hedgehog paracrine signaling (By similarity). Associated with the very-low-density lipoprotein (VLDL) particles to function as a circulating morphogen for endothelial cell integrity maintenance (By similarity). {ECO:0000250|UniProtKB:Q14623, ECO:0000250|UniProtKB:Q62226, ECO:0000269|PubMed:10465785, ECO:0000269|PubMed:10631175, ECO:0000269|PubMed:18582859, ECO:0000269|PubMed:19252479}.
uniprot
proteins
mass_dalton
45485
uniprot
proteins
mutagenesis
MUTAGEN 95; /note="E->K: Knockin mice display brachydactyly type A1 phenotype, characterized by shortened or absent middle phalanges in digits. Defects are due to impaired interaction with PTCH1, leading to decreased smoothened signaling pathway."; /evidence="ECO:0000269|PubMed:19252479
uniprot
proteins
post_translational_modification
PTM: [Indian hedgehog protein]: The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (N-product). N-product is the active species in both local and long-range signaling, whereas the C-product is degraded in the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q62226}.; PTM: [Indian hedgehog protein N-product]: Dually lipidated: a cholesterol moiety is attached to its C-terminus following cleavage. N-palmitoylated by HHAT following cholesterylation; palmitoylation is required for indian hedgehog protein N-product multimerization and full activity. {ECO:0000250|UniProtKB:Q14623}.
uniprot
proteins
protein_family
Hedgehog family
uniprot
proteins
pubmed
10465785
uniprot
proteins
pubmed
10631175
uniprot
proteins
pubmed
18582859
uniprot
proteins
pubmed
19252479
uniprot
proteins
pubmed
23665349
uniprot
proteins
pubmed
7720571
uniprot
proteins
pubmed
7916661
uniprot
proteins
pubmed
9079674
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Indian hedgehog protein]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15465}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q15465}. Note=Co-localizes with HHAT in the ER and Golgi membrane. {ECO:0000250|UniProtKB:Q15465}.; SUBCELLULAR LOCATION: [Indian hedgehog protein N-product]: Secreted {ECO:0000250|UniProtKB:Q14623}. Cell membrane {ECO:0000250|UniProtKB:Q14623}; Lipid-anchor {ECO:0000250|UniProtKB:Q15465}. Note=The dual-lipidated N-product is tethered to the cell membrane where it forms multimers. Further solubilization from the cell surface is required to promote its release from producing cells and act as a morphogen for distant signaling. {ECO:0000250|UniProtKB:Q15465}.
uniprot
proteins