Nlgn1
entrez
192167
canonical
uniprot
Q99K10
canonical
ensembl
ENSMUSG00000063887
resolver
ensp
ENSMUSP00000074565
resolver
ensp
ENSMUSP00000103944
resolver
ensp
ENSMUSP00000142086
resolver
ensp
ENSMUSP00000142200
resolver
enst
ENSMUST00000108308
resolver
enst
ENSMUST00000191835
resolver
genesymbol
Nlgn1
resolver
genesymbol_syn
Kiaa1070
resolver
uniprot
E9QK34
resolver
uniprot_entry
E9QK34_MOUSE
resolver
uniprot_entry
NLGN1_MOUSE
resolver
amino_acid_sequence
MALPRCMWPNYVWRAMMACVVHRGSGAPLTLCLLGCLLQTFHVLSQKLDDVDPLVTTNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKHTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARILATKVGCNVSDTVELVECLQKKPYKELVDQDVQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGVSASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITLRPTRKNSTPVTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAPEEEIMSLQMKHTDLDHECESIHPHEVVLRTACPPDYTLAMRRSPDDIPLMTPNTITMIPNTIPGIQPLHTFNTFTGGQNNTLPHPHPHPHSHSTTRV
uniprot
proteins
function
FUNCTION: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (PubMed:23716671). The protein is involved in nervous system development. {ECO:0000269|PubMed:10892652, ECO:0000269|PubMed:15620359, ECO:0000269|PubMed:16982420, ECO:0000269|PubMed:23716671, ECO:0000269|PubMed:28841651, ECO:0000269|PubMed:30100184}.
uniprot
proteins
mass_dalton
94149
uniprot
proteins
mutagenesis
MUTAGEN 89; /note="P->L: Decreased protein abundance. Not delivered to the plasma membrane. Heterozygotes mice with this mutation display abnormal social behavior."; /evidence="ECO:0000269|PubMed:28841651"; MUTAGEN 90; /note="T->I: No effect on protein abundance. Not associated with changes in subcellular location."; /evidence="ECO:0000269|PubMed:28841651"; MUTAGEN 289; /note="L->P: Decreased protein abundance. Not delivered to the plasma membrane."; /evidence="ECO:0000269|PubMed:28841651"; MUTAGEN 317; /note="G->E: Decreased protein abundance. Not delivered to the plasma membrane."; /evidence="ECO:0000269|PubMed:28841651"; MUTAGEN 611..615; /note="KPRVK->APAVA: Abolishes binding to heparan sulfate and reduces presynaptic differentiation."; /evidence="ECO:0000269|PubMed:30100184"; MUTAGEN 736; /note="R->H: Not associated with changes in subcellular location."; /evidence="ECO:0000269|PubMed:28841651"; MUTAGEN 815; /note="H->Y: Decreased protein abundance. Not associated with changes in subcellular location."; /evidence="ECO:0000269|PubMed:28841651
uniprot
proteins
post_translational_modification
PTM: N-glycosylated, contains high-mannose, hybrid, complex and sialylated N-glycans (PubMed:37865312). N-glycosylation is essential for localization to synapses, dendrites, and the cell membrane, and enhances its availability for trans-synaptic adhesion. O-glycosylated (By similarity). {ECO:0000250|UniProtKB:Q62765, ECO:0000269|PubMed:37865312}.
uniprot
proteins
protein_family
Type-B carboxylesterase/lipase family
uniprot
proteins
pubmed
10892652
uniprot
proteins
pubmed
11329178
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15620359
uniprot
proteins
pubmed
16982420
uniprot
proteins
pubmed
17897391
uniprot
proteins
pubmed
18084303
uniprot
proteins
pubmed
18434543
uniprot
proteins
pubmed
19926856
uniprot
proteins
pubmed
20147539
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23716671
uniprot
proteins
pubmed
28841651
uniprot
proteins
pubmed
28972980
uniprot
proteins
pubmed
30100184
uniprot
proteins
pubmed
37865312
uniprot
proteins
sequence_length
843
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q62765}; Single-pass type I membrane protein {ECO:0000255}. Postsynaptic density {ECO:0000250|UniProtKB:Q62765}. Synaptic cleft {ECO:0000250|UniProtKB:Q62765}. Synaptic cell membrane {ECO:0000250|UniProtKB:Q62765}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q62765}. Synapse {ECO:0000250|UniProtKB:Q62765}. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1. Localizes to dendritic membrane. {ECO:0000250|UniProtKB:Q62765}.
uniprot
proteins
transmembrane_region
TRANSMEM 698..718; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins