E2f1
entrez
399489
canonical
uniprot
O09139
canonical
ensembl
ENSRNOG00000072439
resolver
ensembl
ENSRNOG00055026928
resolver
ensembl
ENSRNOG00060024587
resolver
ensembl
ENSRNOG00065025204
resolver
ensp
ENSRNOP00000022428
resolver
ensp
ENSRNOP00055038124
resolver
ensp
ENSRNOP00060035259
resolver
ensp
ENSRNOP00065035591
resolver
enst
ENSRNOT00000022428
resolver
enst
ENSRNOT00055046483
resolver
enst
ENSRNOT00060042569
resolver
enst
ENSRNOT00065043397
resolver
genesymbol
E2f1
resolver
uniprot_entry
E2F1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: BIRC2/c-IAP1 stimulates its transcriptional activity. {ECO:0000250|UniProtKB:Q01094}.
uniprot
proteins
amino_acid_sequence
MAVAPAGGQHAPALEALLGAGALRLLDSSQIVIISTAPDVGAPQVPTGPAAPPAGPRDPDVLLFATPQAPRPAPSAPRPALGRPPVKRRLDLETDHQYLAGSSGPFRGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSRTMVGIGQRLEGLTQDLQQLQESEQQLDHLMHICTTQLQLLSEDSDIQRLAYVTCQDLRSIADPAEQMVIVIKAPPETQLQAVDSAETFQISLKSKQGPIDVFLCPEESAEGISPGRTSYQETSGEDRNADSGTAGPPPSPPSTSPTLDPSQSLLGLEQEAVLPRIGNLRAPMEEDRLSPLVAADSLLEHVKEDFSGLLPGEFISLSPPHEAVDYHFGLEEGEGIRDLFDCDFGDLTPLDF
uniprot
proteins
function
FUNCTION: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. Directly activates transcription of PEG10. Positively regulates transcription of RRP1B. {ECO:0000250|UniProtKB:Q01094}.
uniprot
proteins
mass_dalton
46548
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation by CHEK2 stabilizes E2F1 upon DNA damage and regulates its effect on transcription and apoptosis. Phosphorylation at Ser-398 by GSK3B promotes interaction with USP11, leading to its deubiquitination and stabilization. {ECO:0000250|UniProtKB:Q01094}.; PTM: Ubiquitinated via 'Lys-63'-linked ubiquitin, leading to its degradation. Deubiquitinated by USP11 following phosphorylation by GSK3B, promoting its stability. {ECO:0000250|UniProtKB:Q01094}.; PTM: Acetylation stimulates DNA-binding. Enhanced under stress conditions such as DNA damage and inhibited by retinoblastoma protein RB1. Regulated by KAP1/TRIM28 which recruits HDAC1 to E2F1 resulting in deacetylation (By similarity). {ECO:0000250|UniProtKB:Q01094}.; PTM: Methylation at Lys-183 by SETD7 promotes E2F1 ubiquitin-dependent proteasomal degradation. {ECO:0000250|UniProtKB:Q01094}.
uniprot
proteins
protein_family
E2F/DP family
uniprot
proteins
pubmed
20176812
uniprot
proteins
pubmed
8673024
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q01094}.
uniprot
proteins