Q9JJS0
uniprot
Q9JJS0
canonical
amino_acid_sequence
MGVAGCGRPREARALLLLLLLLPPLLAAAVPPDRGLTNGPSEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDMDECDNTLNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDMDECLENNGGCQHICTNVIGSYECRCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCGHICKEAPRGSVACECRPGFELAKNQKDCILTCNHGNGGCQHSCEDTAEGPECSCHPRYRLHADGRSCLEQEGTVLEGTESNATSVADGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPTGFTLQVDGKTCKDIDECQTRNGGCNHFCKNTVGSFDCSCKKGFKLLTDEKSCQDVDECSLERTCDHSCINHPGTFICACNPGYTLYSFTHCGDTNECSVNNGGCQQVCINTVGSYECQCHPGFKLHWNKKDCVEVKGFPPTSMTPRVSLHCGKSGGGDRCFLRCRSGIHLSSDVVTVRTSVTFKLNEGKCSLQKAKLSPEGLRPALPERHSSVKESFQYANLTCSPGKQVPGALGRLNAPKEMFITVEFERETYEKEVTASCNLSCVVKRTEKRLRKALRTLKRAAHREQFHLQLSGMDLDMAKTPSRVSGQHEETCGVGQGHEESQCVSCRAGTYYDGSQERCILCPNGTFQNEEGQVTCEPCPRPENLGSLKISEAWNVSDCGGLCQPGEYSANGFAPCQLCALGTFQPDVGRTSCLSCGGGLPTKHLGATSFQDCETRVQCSPGHFYNTTTHRCIRCPLGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQCKNRKCGGELGDFTGYIESPNYPGNYPANSECTWTINPPPKRRILIVVPEIFLPIEDDCGDYLVMRKTSSSNSVTTYETCQTYERPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVTYDEDYQELIEDIVRDGRLYASENHQEILKDKKLIKALFDVLAHPQNYFKYTAQESREMFPRSFIRLLRSKVSRFLRPYK
uniprot
proteins
function
FUNCTION: Lipid-binding protein carrier required for sonic hedgehog (SHH) long-range signaling: binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) and promotes its release from producing cells, allowing it to act as a morphogen for distant signaling (PubMed:22677548, PubMed:22902404, PubMed:33038332). ShhN is then transferred to the CDON-BOC heterodimer and GAS1 coreceptors to reach its target, the patched receptor (PTCH1 or PTCH2), followed by activation of the smoothened signaling pathway (PubMed:33038332). May also enhance the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687). {ECO:0000269|PubMed:22677548, ECO:0000269|PubMed:22902404, ECO:0000269|PubMed:24522195, ECO:0000269|PubMed:27834687, ECO:0000269|PubMed:33038332}.
uniprot
proteins
mass_dalton
109924
uniprot
proteins
mutagenesis
MUTAGEN 845..854; /note="ILIVVPEIFL->AAAAAPEAAA: No interaction with SHH and no secretion of SHH."; /evidence="ECO:0000269|PubMed:22902404
uniprot
proteins
pubmed
11287194
uniprot
proteins
pubmed
11528127
uniprot
proteins
pubmed
22677548
uniprot
proteins
pubmed
22902404
uniprot
proteins
pubmed
24522195
uniprot
proteins
pubmed
26875496
uniprot
proteins
pubmed
27834687
uniprot
proteins
pubmed
33038332
uniprot
proteins
sequence_length
997
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:33038332}. Cell surface {ECO:0000269|PubMed:33038332}. Note=Secreted and tethered at the cell surface. {ECO:0000269|PubMed:33038332}.
uniprot
proteins