Gabrg1
entrez
14405
canonical
uniprot
Q9R0Y8
canonical
ensembl
ENSMUSG00000001260
resolver
ensp
ENSMUSP00000031119
resolver
ensp
ENSMUSP00000142454
resolver
ensp
ENSMUSP00000182337
resolver
enst
ENSMUST00000031119
resolver
genesymbol
Gabrg1
resolver
uniprot
Q8BHM6
resolver
uniprot_entry
GBRG1_MOUSE
resolver
uniprot_sec
Q8BHM6
resolver
amino_acid_sequence
MGSGKAFLFSPSLLWSQTRGVRLIFLLLTLHLGNCVDKADDEDDEDLTMNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWSDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEISHTISGDYIIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNNKGKTTRGRKLKNKTSASPGLHAGSTLIPMNSISLPQGEDDYGYQCLEGKDCTSFFCCFDDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
uniprot
proteins
function
FUNCTION: Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). {ECO:0000250|UniProtKB:P08219, ECO:0000250|UniProtKB:P18507, ECO:0000250|UniProtKB:P23574}.
uniprot
proteins
mass_dalton
53407
uniprot
proteins
post_translational_modification
PTM: May be palmitoylated. {ECO:0000250|UniProtKB:P22723}.
uniprot
proteins
protein_family
GABRG1 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9527017
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000255}. Cell membrane; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 274..294; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 301..320; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 329..349; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 445..465; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins