Dpep1
entrez
94199
canonical
uniprot
P31430
canonical
ensembl
ENSRNOG00000015880
resolver
ensembl
ENSRNOG00055020725
resolver
ensembl
ENSRNOG00060018678
resolver
ensembl
ENSRNOG00065019033
resolver
ensp
ENSRNOP00000021397
resolver
ensp
ENSRNOP00055028685
resolver
ensp
ENSRNOP00060026185
resolver
ensp
ENSRNOP00065025541
resolver
enst
ENSRNOT00000021397
resolver
enst
ENSRNOT00055035385
resolver
enst
ENSRNOT00060032173
resolver
enst
ENSRNOT00065032005
resolver
genesymbol
Dpep1
resolver
genesymbol_syn
Rdp
resolver
uniprot
Q6IN35
resolver
uniprot_entry
DPEP1_RAT
resolver
uniprot_sec
Q6IN35
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by L-penicillamine. Beta-lactamase activity is inhibited by cilastatin. {ECO:0000250|UniProtKB:P16444}.
uniprot
proteins
amino_acid_sequence
MLIIWWFWSLLAICASDSFRNQAENIMRTTPVIDGHNDLPWQMLTLFNNQLRKSEANLSALAETHTNIPKLRAGFVGGQFWSAYMPCDTQNKDAVKRILEQIDVIHRMCQLYPETFECVTNSSDILQAFRRGKVASLIGVEGGHLIDSSLGVLRTLYHLGMRYLTLTHNCNTPWADNWLVDKGDDEAESQGLSPFGKLVLNEMNRLGVMIDLSHVSVATMKDALQLSKAPVIFSHSSAYSVCPHRRNVPDDVLQLVKSTNSLVMVNFYNQFVSCSDSATLSQVADHLDHIKKVAGAGAVGLGGDYDGVTNLPVGLEDVSKYPDLIAELLRRNWTETEVRGLLAENLLRVFSAVELVSNIMQVPEEETIPVEKLDGSCRTFYGHSRAPSIHLQIGALLASLASLVFSLHLL
uniprot
proteins
ec_number
3.4.13.19
uniprot
proteins
ec_number
3.5.2.6
uniprot
proteins
function
FUNCTION: Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4. Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation. Also possesses beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics. {ECO:0000250|UniProtKB:P31428}.; FUNCTION: Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver. {ECO:0000250|UniProtKB:P31428}.
uniprot
proteins
mass_dalton
45522
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
protein_family
Peptidase M19 family
uniprot
proteins
pubmed
1420313
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P16444}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P16444}. Cell projection, microvillus membrane {ECO:0000250|UniProtKB:P16444}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P16444}. Note=Brush border membrane. {ECO:0000250|UniProtKB:P31429}.
uniprot
proteins