Ankzf1
entrez
52231
canonical
uniprot
Q80UU1
canonical
ensembl
ENSMUSG00000026199
resolver
ensp
ENSMUSP00000136163
resolver
ensp
ENSMUSP00000276072
resolver
ensp
ENSMUSP00000276075
resolver
ensp
ENSMUSP00000276080
resolver
enst
ENSMUST00000152233
resolver
genesymbol
Ankzf1
resolver
genesymbol_syn
D1Ertd161e
resolver
uniprot
B9EKG0
resolver
uniprot
J3QM81
resolver
uniprot
Q9CZF5
resolver
uniprot_entry
ANKZ1_MOUSE
resolver
uniprot_entry
J3QM81_MOUSE
resolver
uniprot_sec
B9EKG0
resolver
uniprot_sec
Q9CZF5
resolver
amino_acid_sequence
MAKPAGDAAVGSRSGELFLPSVSSSATSPAPSAAPAPASVSLLSLNGEAPLIRGLSLVSQAPGEALAWAPRTSCPGENTSSGGKVSPYSLEISEKLFCSACDQIFQNHQEQREHYKLDWHRFNLKQRLKNKPLLSASDFEQQSSTGDLSSISGSDDTDSSSEEDLLPLDEGRAESEKPNRPPGFYPHRVLFKNAQGQFLYAYRCVLGPHQIPPEKAELLLQNLQNGGPRYYVVLMAAAGHFAGAIFQGREVVAHKTFHRYTVRAKRGTAQGLQDAHGRASRSAGANLRRYNEAMLYKDVRNLLAGPIWSKALGEAETVLFRAPRSGRSLFFGGQGAPLQRDDPRLWDIPLTTRRPTFGELQRVLHKLTTLQVYDEDPREMVRFHSPETHWKPVREERKKDTEKEKTKVPSDANKPLGQDEEPLKQGSESQEEDGSEVELELVELTLGTLDLREFEVLPKRRRRRKKKERSQEQQCGAHGPLPQQPQDEPFSQPTQEVETPLDTLVYEAKAPGQPELWDTLLAACRAGEVEVLKLQLATGLVDPGVKSLLNAPLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNLDAYDYNKARVPGPLTQEMEARQATRKKEQKAARRQREQQQRKQREQEEQEQEEQRRFAALSDREKRALAAERRLAAQLGAPSPPVPDSAVASAGRCWSCGVSLQGLIPFHYLDFSFCSTRCLRDHRSQAGRPSS
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation. The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts. ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs. ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1. Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress. {ECO:0000250|UniProtKB:Q9H8Y5}.
uniprot
proteins
mass_dalton
82976
uniprot
proteins
protein_family
ANKZF1/VMS1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
748
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H8Y5}. Note=Translocates to the mitochondria upon exposure to hydrogen peroxide. {ECO:0000250|UniProtKB:Q9H8Y5}.
uniprot
proteins