EPHA5
entrez
2044
canonical
uniprot
P54756
canonical
ensembl
ENSG00000145242
resolver
ensp
ENSP00000273854
resolver
ensp
ENSP00000346899
resolver
ensp
ENSP00000389208
resolver
ensp
ENSP00000427638
resolver
ensp
ENSP00000478537
resolver
ensp
ENSP00000480763
resolver
ensp
ENSP00000563363
resolver
enst
ENST00000432638
resolver
enst
ENST00000511294
resolver
enst
ENST00000613740
resolver
enst
ENST00000622150
resolver
genesymbol
EPHA5
resolver
genesymbol_syn
BSK
resolver
genesymbol_syn
EHK1
resolver
genesymbol_syn
HEK7
resolver
genesymbol_syn
TYRO4
resolver
hgnc
HGNC:3389
resolver
uniprot
A0A087WUC1
resolver
uniprot
A0A087WX63
resolver
uniprot
A0A384MU00
resolver
uniprot
B7ZKJ3
resolver
uniprot
B7ZKW7
resolver
uniprot
F8VP57
resolver
uniprot
F8W9W0
resolver
uniprot
Q59FT4
resolver
uniprot
Q7Z3F2
resolver
uniprot_entry
A0A087WUC1_HUMAN
resolver
uniprot_entry
A0A087WX63_HUMAN
resolver
uniprot_entry
A0A384MU00_HUMAN
resolver
uniprot_entry
B7ZKJ3_HUMAN
resolver
uniprot_entry
B7ZKW7_HUMAN
resolver
uniprot_entry
EPHA5_HUMAN
resolver
uniprot_entry
F8VP57_HUMAN
resolver
uniprot_entry
F8W9W0_HUMAN
resolver
uniprot_entry
Q59FT4_HUMAN
resolver
uniprot_sec
Q7Z3F2
resolver
amino_acid_sequence
MRGSGPRGAGRRRPPSGGGDTPITPASLAGCYSAPRRAPLWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDDQNGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVSGSCVNHSVTDEPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQVCRPGFFKASPHIQSCGKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSAPRNAISNVNETSVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECGGHVRYLPRQSGLKNTSVMMVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETTITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVFAASSDQSQIPVIAVSVTVGVILLAVVIGVLLSGSCCECGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNASCRVSNLLAEHSPLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKVQLVNGMVPL
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
114803
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation is stimulated by the ligand EFNA5. Dephosphorylation upon stimulation by glucose, inhibits EPHA5 forward signaling and results in insulin secretion (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Ephrin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10375373
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
7748564
uniprot
proteins
pubmed
7898931
uniprot
proteins
pubmed
9191074
uniprot
proteins
pubmed
9267020
uniprot
proteins
sequence_length
1037
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10375373}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P54757}. Cell projection, dendrite {ECO:0000269|PubMed:10375373, ECO:0000269|PubMed:9191074}.
uniprot
proteins
transmembrane_region
TRANSMEM 574..594; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins