Cxcr3
entrez
84475
canonical
uniprot
Q9JII9
canonical
ensembl
ENSRNOG00055030134
resolver
ensembl
ENSRNOG00060027220
resolver
ensembl
ENSRNOG00065016507
resolver
ensp
ENSRNOP00055043231
resolver
ensp
ENSRNOP00060039298
resolver
ensp
ENSRNOP00065021613
resolver
enst
ENSRNOT00055052298
resolver
enst
ENSRNOT00060047226
resolver
enst
ENSRNOT00065027486
resolver
genesymbol
Cxcr3
resolver
uniprot_entry
CXCR3_RAT
resolver
amino_acid_sequence
MYLEVSERQVLDASDIAFLLENSTSPYDYGENESDFSDSPPCPQDFSLNFDRTFLPVLYSLLFLLGLLGNGAVAAVLLSQRTALSSTDTFLLHLAVADVLLVLTLPLWAVDAAAQWVFGSGLCKVAGALFNINFYAGAFLLACISFDRYLSIVHATQIYRRDPWVRVALTCIVVWGLCVLFALPDFIFLSASHDQRLNATHCQYNFPQVGRTALRVLQLVAGFLMPLLVMAYCYAHILAVLLVSRGQRRFRAMRLVVVVVVAFAVCWTPYHLVVLVDILMDVGVLARNCGRESHVDVAKSVTSGMGYMHCCLNPLLYAFVGVKFKEQMWMLLMRLGRSDQRGPQRQPSSSRRESSWSETTEASYLGL
uniprot
proteins
function
FUNCTION: Receptor for the C-X-C chemokines CXCL9, CXCL10 and CXCL11, and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G protein signaling pathway. Probably promotes cell chemotaxis response (By similarity). Receptor for chemokine CCL21. Upon activation by PF4, induces activated T-lymphocyte migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling (By similarity). {ECO:0000250|UniProtKB:O88410, ECO:0000250|UniProtKB:P49682}.
uniprot
proteins
mass_dalton
40935
uniprot
proteins
post_translational_modification
PTM: Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding. {ECO:0000250}.; PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10825390
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 57..77; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 126..146; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 169..189; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 223..243; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 256..276; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 301..321; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins