PAPPA
entrez
5069
canonical
uniprot
Q13219
canonical
ensembl
ENSG00000182752
resolver
ensp
ENSP00000330658
resolver
enst
ENST00000328252
resolver
genesymbol
DIPLA1
resolver
genesymbol
PAPPA
resolver
hgnc
HGNC:8602
resolver
uniprot
B1AMF9
resolver
uniprot
B4DTA8
resolver
uniprot
Q08371
resolver
uniprot
Q68G52
resolver
uniprot
Q7Z613
resolver
uniprot
Q9UDK7
resolver
uniprot_entry
B4DTA8_HUMAN
resolver
uniprot_entry
PAPP1_HUMAN
resolver
uniprot_entry
Q7Z613_HUMAN
resolver
uniprot_sec
B1AMF9
resolver
uniprot_sec
Q08371
resolver
uniprot_sec
Q68G52
resolver
uniprot_sec
Q9UDK7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by complexation with the proform of PRG2. {ECO:0000269|PubMed:10913121}.
uniprot
proteins
amino_acid_sequence
MRLWSWVLHLGLLSAALGCGLAERPRRARRDPRAGRPPRPAAGPATCATRAARGRRASPPPPPPPGGAWEAVRVPRRRQQREARGATEEPSPPSRALYFSGRGEQLRLRADLELPRDAFTLQVWLRAEGGQRSPAVITGLYDKCSYISRDRGWVVGIHTISDQDNKDPRYFFSLKTDRARQVTTINAHRSYLPGQWVYLAATYDGQFMKLYVNGAQVATSGEQVGGIFSPLTQKCKVLMLGGSALNHNYRGYIEHFSLWKVARTQREILSDMETHGAHTALPQLLLQENWDNVKHAWSPMKDGSSPKVEFSNAHGFLLDTSLEPPLCGQTLCDNTEVIASYNQLSSFRQPKVVRYRVVNLYEDDHKNPTVTREQVDFQHHQLAEAFKQYNISWELDVLEVSNSSLRRRLILANCDISKIGDENCDPECNHTLTGHDGGDCRHLRHPAFVKKQHNGVCDMDCNYERFNFDGGECCDPEITNVTQTCFDPDSPHRAYLDVNELKNILKLDGSTHLNIFFAKSSEEELAGVATWPWDKEALMHLGGIVLNPSFYGMPGHTHTMIHEIGHSLGLYHVFRGISEIQSCSDPCMETEPSFETGDLCNDTNPAPKHKSCGDPGPGNDTCGFHSFFNTPYNNFMSYADDDCTDSFTPNQVARMHCYLDLVYQGWQPSRKPAPVALAPQVLGHTTDSVTLEWFPPIDGHFFERELGSACHLCLEGRILVQYASNASSPMPCSPSGHWSPREAEGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQGCYLELEFLYPLVPESLTIWVTFVSTDWDSSGAVNDIKLLAVSGKNISLGPQNVFCDVPLTIRLWDVGEEVYGIQIYTLDEHLEIDAAMLTSTADTPLCLQCKPLKYKVVRDPPLQMDVASILHLNRKFVDMDLNLGSVYQYWVITISGTEESEPSPAVTYIHGSGYCGDGIIQKDQGEQCDDMNKINGDGCSLFCRQEVSFNCIDEPSRCYFHDGDGVCEEFEQKTSIKDCGVYTPQGFLDQWASNASVSHQDQQCPGWVIIGQPAASQVCRTKVIDLSEGISQHAWYPCTISYPYSQLAQTTFWLRAYFSQPMVAAAVIVHLVTDGTYYGDQKQETISVQLLDTKDQSHDLGLHVLSCRNNPLIIPVVHDLSQPFYHSQAVRVSFSSPLVAISGVALRSFDNFDPVTLSSCQRGETYSPAEQSCVHFACEKTDCPELAVENASLNCSSSDRYHGAQCTVSCRTGYVLQIRRDDELIKSQTGPSVTVTCTEGKWNKQVACEPVDCSIPDHHQVYAASFSCPEGTTFGSQCSFQCRHPAQLKGNNSLLTCMEDGLWSFPEALCELMCLAPPPVPNADLQTARCRENKHKVGSFCKYKCKPGYHVPGSSRKSKKRAFKTQCTQDGSWQEGACVPVTCDPPPPKFHGLYQCTNGFQFNSECRIKCEDSDASQGLGSNVIHCRKDGTWNGSFHVCQEMQGQCSVPNELNSNLKLQCPDGYAIGSECATSCLDHNSESIILPMNVTVRDIPHWLNPTRVERVVCTAGLKWYPHPALIHCVKGCEPFMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKVTPFPMSCDLQGDCACRDPQAQEHSRKDLRGYSHG
uniprot
proteins
ec_number
3.4.24.79
uniprot
proteins
function
FUNCTION: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. {ECO:0000269|PubMed:10077652, ECO:0000269|PubMed:10913121, ECO:0000269|PubMed:11522292}.
uniprot
proteins
mass_dalton
180973
uniprot
proteins
post_translational_modification
PTM: There appear to be no free sulfhydryl groups.
uniprot
proteins
protein_family
Peptidase M43B family
uniprot
proteins
pubmed
10077652
uniprot
proteins
pubmed
10491647
uniprot
proteins
pubmed
10913121
uniprot
proteins
pubmed
11522292
uniprot
proteins
pubmed
11822024
uniprot
proteins
pubmed
12421832
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7508748
uniprot
proteins
pubmed
7526035
uniprot
proteins
pubmed
7539791
uniprot
proteins
pubmed
7685339
uniprot
proteins
pubmed
8620868
uniprot
proteins
sequence_length
1627
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10077652}.
uniprot
proteins