Abcg4
entrez
192663
canonical
uniprot
Q91WA9
canonical
ensembl
ENSMUSG00000032131
resolver
ensp
ENSMUSP00000034648
resolver
ensp
ENSMUSP00000124647
resolver
ensp
ENSMUSP00000316088
resolver
enst
ENSMUST00000034648
resolver
enst
ENSMUST00000161354
resolver
genesymbol
Abcg4
resolver
genesymbol_syn
White2
resolver
uniprot
Q8K4E1
resolver
uniprot
Q8VBS9
resolver
uniprot_entry
ABCG4_MOUSE
resolver
uniprot_sec
Q8K4E1
resolver
uniprot_sec
Q8VBS9
resolver
amino_acid_sequence
MAEKALEAVGCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAHGGRTVICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCTMAEKKSSPGKNELPAHCPTCPPELDPIESHTFATSTLTQFCILFRRTFLSILRDTVLTHLRFMSHVLIGVLIGLLYLHIGDDASKVFNNTGFLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYTLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALAIATALVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGLILTIYGMERGHLTCLDEQCPFRDPQIILRELDVEEAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSER
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL) (PubMed:15210959, PubMed:17916878, PubMed:18039927). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (PubMed:29042617). Induces apoptosis in various cells (By similarity). {ECO:0000250|UniProtKB:Q9H172, ECO:0000269|PubMed:15210959, ECO:0000269|PubMed:17916878, ECO:0000269|PubMed:18039927, ECO:0000269|PubMed:29042617}.
uniprot
proteins
mass_dalton
72098
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCG family
uniprot
proteins
protein_family
Eye pigment precursor importer (TC 3.A.1.204) subfamily
uniprot
proteins
pubmed
11856881
uniprot
proteins
pubmed
12137944
uniprot
proteins
pubmed
12183068
uniprot
proteins
pubmed
15210959
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17916878
uniprot
proteins
pubmed
18039927
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19633360
uniprot
proteins
pubmed
29042617
uniprot
proteins
sequence_length
646
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H172}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17916878}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:17916878}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 394..414; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 426..446; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 473..493; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 504..524; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 533..553; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 618..638; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins