Tcp11
entrez
309641
canonical
uniprot
Q5XI00
canonical
ensembl
ENSRNOG00000000499
resolver
ensembl
ENSRNOG00060005967
resolver
ensp
ENSRNOP00000039755
resolver
ensp
ENSRNOP00000092987
resolver
ensp
ENSRNOP00060007398
resolver
enst
ENSRNOT00000109959
resolver
enst
ENSRNOT00060009865
resolver
genesymbol
Tcp11
resolver
uniprot
A0A8I6GK20
resolver
uniprot_entry
A0A8I6GK20_RAT
resolver
uniprot_entry
TCP11_RAT
resolver
amino_acid_sequence
MPDLKERAARKEPGAAESASRESRGGNTRESASSAQGHRSRRFNRRSSTAALTPGSAQGRGVQTAPRAPVGHGGLRTGLTSRCPQPSARAKLPSVTRGAPLPPSPGKGHFGATPISHRLGLTERVHDASKLDCHLEDRKSASSLESRGKEVMPSDFWDHLKEQLSAVPPDFSCALELLKEIKEILLSLLLPRQSRLRNEIEEALDMEFLHQQADRGDLNVSYLSKYILNMMVLLCAPVRDEAVQRLENISDPVRLLRGIFQVLGQMKMDMVNYTIQSLQPQLQEHSIQFERAQFQERLNKDPSLLNHTTKWLTQAATQLIAPSGSCYDIQDPSSSSGPSPSDIAIPEPLSPAMVLSQGFLNLLTWDPENEEFPETLLADRSRLQELESQQNQLTILASVLLVASSFSGSVLFGSPQFVDRLKRITKSLVEDFNSRPEEVMQTVSDQVTEEIHQSLKNMGLSPLSSENTDSLIGQLQNIAKKENCVRSVIDQRIHLFLKCCFVLGVQRSLLDLPGGLSLIEAELAELGQKFVSLTHHNQQVFAPYYTEILKTLINPVQTLTTKVGSL
uniprot
proteins
function
FUNCTION: Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway. {ECO:0000250|UniProtKB:Q01755}.
uniprot
proteins
mass_dalton
62612
uniprot
proteins
post_translational_modification
PTM: Constitutively phosphorylated on serine, threonine and tyrosine residues within the head and tail regions of noncapacitated spermatozoa. Phosphorylation on tyrosine residues increases upon sperm capacitation within the acrosomal region in a protein kinase A (PKA)-dependent signaling pathway. {ECO:0000250|UniProtKB:Q01755}.
uniprot
proteins
protein_family
TCP11 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
566
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q01755}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q01755}. Note=Localizes on the acrosomal cap region of acrosome-intact, but not acrosome-reacted sperm. Colocalizes with MROH2B and PRKACA on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm. {ECO:0000250|UniProtKB:Q01755}.
uniprot
proteins
transmembrane_region
TRANSMEM 393..413; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins