Arsb
entrez
25227
canonical
uniprot
P50430
canonical
ensembl
ENSRNOG00000011150
resolver
ensembl
ENSRNOG00055003962
resolver
ensembl
ENSRNOG00060027395
resolver
ensembl
ENSRNOG00065023620
resolver
ensp
ENSRNOP00000014860
resolver
ensp
ENSRNOP00055004831
resolver
ensp
ENSRNOP00060039552
resolver
ensp
ENSRNOP00065032931
resolver
enst
ENSRNOT00000014860
resolver
enst
ENSRNOT00055006324
resolver
enst
ENSRNOT00060047526
resolver
enst
ENSRNOT00065040435
resolver
genesymbol
Arsb
resolver
uniprot
B4F7E2
resolver
uniprot
Q32KK1
resolver
uniprot_entry
ARSB_RAT
resolver
uniprot_entry
B4F7E2_RAT
resolver
uniprot_sec
Q32KK1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by ethanol. {ECO:0000269|PubMed:24311516}.
uniprot
proteins
amino_acid_sequence
MGELSGCTGGSRAGGPGPRLPLLLLLLLWPARASDAAPPPHVVFVLADDLGWNDLGFHGSVIRTPHLDALAAGGVVLDNYYVQPLCTPSRSQLLTGRYQIHMGLQHYLIMTCQPNCVPLDEKLLPQLLKDAGYATHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYTHEACAPIECLNGTRCALDLRDGEEPAKEYTDIYSTNIFTKRATTLIANHPPEKPLFLYLAFQSVHDPLQVPEEYMEPYDFIQDKHRRIYAGMVSLLDEAVGNVTKALKSRGLWNNTVLIFSTDNGGQTRSGGNNWPLRGRKGTLWEGGIRGAGFVASPLLKQKGVKSRELMHITDWLPTLVNLAGGSTHGTKPLDGFDVWETISEGSPSPRVELLLNIDPDFFDGLPCPGKNTTPEKNDSFPLEHSAFNTSIHAGIRYKNWKLLTGYPGCGYWFPPPSQSNISEVPSVDSPTKTLWLFDINRDPEERHDVSREHPHIVQNLLSRLQYYHEHSVPSYFPPLDPRCDPKGTGVWSPWM
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Arsb are the cause of mucopolysaccharidosis type VI (MPS-VI) (PubMed:8575749). {ECO:0000269|PubMed:8575749}.
uniprot
proteins
ec_number
3.1.6.12
uniprot
proteins
function
FUNCTION: Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:24311516). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (PubMed:24311516). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). {ECO:0000250|UniProtKB:P15848, ECO:0000269|PubMed:24311516}.
uniprot
proteins
mass_dalton
58959
uniprot
proteins
protein_family
Sulfatase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16174644
uniprot
proteins
pubmed
19536613
uniprot
proteins
pubmed
24311516
uniprot
proteins
pubmed
8575749
uniprot
proteins
sequence_length
528
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome. Cell surface {ECO:0000269|PubMed:19536613}.
uniprot
proteins