Rad18
entrez
58186
canonical
uniprot
Q9QXK2
canonical
ensembl
ENSMUSG00000030254
resolver
ensp
ENSMUSP00000070619
resolver
ensp
ENSMUSP00000076341
resolver
ensp
ENSMUSP00000293513
resolver
ensp
ENSMUSP00000335623
resolver
ensp
ENSMUSP00000335626
resolver
enst
ENSMUST00000068487
resolver
enst
ENSMUST00000077088
resolver
genesymbol
Rad18
resolver
genesymbol_syn
Rad18sc
resolver
uniprot
E9Q392
resolver
uniprot
Q8CDH2
resolver
uniprot
Q8CED3
resolver
uniprot
Q9CZB8
resolver
uniprot_entry
E9Q392_MOUSE
resolver
uniprot_entry
Q8CDH2_MOUSE
resolver
uniprot_entry
Q8CED3_MOUSE
resolver
uniprot_entry
RAD18_MOUSE
resolver
uniprot_sec
Q9CZB8
resolver
amino_acid_sequence
MEVLAEPRWPPGLAVMKTIDDLLRCGICFEYFNIAVIIPQCSHNYCSLCIRKFLSYKTQCPTCCVAVTEPDLRNNRLLDELVKSMNFARTHLLQFALESPPISPVSSTSKKVVVKVHNADAAQHPVKQANRLMDKFLIRETGDCVFELLGKENERKFSPQKELSTSAEIKETSLLGKPVLGLSDANGPVTPSTSTMKLDTKVSCPVCGVSIPENHINKHLDSCLSREEKKESLRSSAHKRKPLPKTVYNLLSDRDLKKKLKQYGLSVQGNKQQLIKRHQEFVHMYNAQCDALHPKSAAEIVQEIESMEKTRMRLEASKLNENVMVFTKNQTEKEIEEVHSEYRKKHQNAFQLLVDQAKKGYKKTGRVSQAAAMRTDEPAETLPSMRTDEPAETLPSMRTDEPAETLPLMRADEPAETLPSECIAQEDNVSFSDTVSVTNHFPQPQLDSPGPSEPERPDDSSSCTDILFSSDSDSCNRNDQNREVSPQQTRRTRASECVEIEPRNKRNKN
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.
uniprot
proteins
mass_dalton
57412
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
RAD18 family
uniprot
proteins
pubmed
11013078
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NS91}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9NS91}. Note=Associates with chromatin. Colocalizes with SLF1 in the nucleus and to centrosomes. Relocalizes with SLF1 to nuclear foci in response to DNA damage. Accumulates with the SLF1-SLF2 and SMC5-SMC6 complexes at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner. {ECO:0000250|UniProtKB:Q9NS91}.
uniprot
proteins