Aqp4
entrez
25293
canonical
uniprot
P47863
canonical
ensembl
ENSRNOG00000016043
resolver
ensp
ENSRNOP00000050942
resolver
ensp
ENSRNOP00000063720
resolver
ensp
ENSRNOP00000072488
resolver
ensp
ENSRNOP00000073052
resolver
ensp
ENSRNOP00000108306
resolver
enst
ENSRNOT00000048109
resolver
enst
ENSRNOT00000068150
resolver
genesymbol
Aqp4
resolver
uniprot
A0A0G2K4I1
resolver
uniprot
A0A0H2UHZ1
resolver
uniprot
A0A8L2UNG3
resolver
uniprot
Q8CIY8
resolver
uniprot_entry
A0A0H2UHZ1_RAT
resolver
uniprot_entry
A0A8L2UNG3_RAT
resolver
uniprot_entry
AQP4_RAT
resolver
uniprot_sec
A0A0G2K4I1
resolver
uniprot_sec
Q8CIY8
resolver
amino_acid_sequence
MSDGAAARRWGKCGPPCSRESIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYITAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSVALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGSYMEVEDNRSQVETEDLILKPGVVHVIDIDRGDEKKGKDSSGEVLSSV
uniprot
proteins
function
FUNCTION: Forms a water-specific channel (PubMed:19800950, PubMed:7509789, PubMed:7528931). Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity). {ECO:0000250|UniProtKB:P55088, ECO:0000269|PubMed:19800950, ECO:0000269|PubMed:7509789, ECO:0000269|PubMed:7528931}.
uniprot
proteins
mass_dalton
34480
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="C->A: Reduced palmitoylation. Loss of palmitoylation; when associated with A-17."; /evidence="ECO:0000269|PubMed:18179769"; MUTAGEN 17; /note="C->A: Reduced palmitoylation. Loss of palmitoylation; when associated with A-13."; /evidence="ECO:0000269|PubMed:18179769"; MUTAGEN 180; /note="S->A: Decreases internalization from the cell membrane in response to PKC activation."; /evidence="ECO:0000269|PubMed:19800950"; MUTAGEN 201; /note="H->P: Partial loss of transport activity."; /evidence="ECO:0000269|PubMed:7528931
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PKC at Ser-180 promotes internalization from the cell membrane, reducing the conductance by 50% (PubMed:19800950). Phosphorylation by PKG at Ser-111 in response to glutamate increases conductance by 40% (By similarity). {ECO:0000250|UniProtKB:P55088, ECO:0000269|PubMed:19800950}.; PTM: Isoform Long: Palmitoylated on its N-terminal region. Isoform 3: Not palmitoylated. {ECO:0000269|PubMed:18179769}.
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
12359252
uniprot
proteins
pubmed
12692561
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16325200
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
18179769
uniprot
proteins
pubmed
19406128
uniprot
proteins
pubmed
19800950
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
29055082
uniprot
proteins
pubmed
7509789
uniprot
proteins
pubmed
7528931
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16325200, ECO:0000269|PubMed:18179769, ECO:0000269|PubMed:19800950, ECO:0000269|PubMed:29055082, ECO:0000269|PubMed:7509789, ECO:0000269|PubMed:7528931}; Multi-pass membrane protein {ECO:0000269|PubMed:16325200, ECO:0000269|PubMed:19406128}. Basolateral cell membrane {ECO:0000250|UniProtKB:P55088}; Multi-pass membrane protein {ECO:0000269|PubMed:16325200, ECO:0000269|PubMed:19406128}. Endosome membrane {ECO:0000305|PubMed:19800950}. Cell membrane, sarcolemma {ECO:0000269|PubMed:29055082}; Multi-pass membrane protein {ECO:0000269|PubMed:16325200, ECO:0000269|PubMed:19406128}. Cell projection {ECO:0000269|PubMed:29055082}. Note=Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane (PubMed:19800950). Detected on brain astrocyte processes and astrocyte endfeet close to capillaries (PubMed:29055082). {ECO:0000269|PubMed:19800950, ECO:0000269|PubMed:29055082}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..57; /note="Helical"; /evidence="ECO:0000269|PubMed:16325200, ECO:0000269|PubMed:19406128"; TRANSMEM 70..89; /note="Helical"; /evidence="ECO:0000269|PubMed:16325200, ECO:0000269|PubMed:19406128"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000269|PubMed:16325200, ECO:0000269|PubMed:19406128"; TRANSMEM 156..176; /note="Helical"; /evidence="ECO:0000269|PubMed:16325200, ECO:0000269|PubMed:19406128"; TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000269|PubMed:16325200, ECO:0000269|PubMed:19406128"; TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000269|PubMed:16325200, ECO:0000269|PubMed:19406128
uniprot
proteins