Hmgcs2
entrez
24450
canonical
uniprot
P22791
canonical
ensembl
ENSRNOG00000019120
resolver
ensembl
ENSRNOG00055032791
resolver
ensp
ENSRNOP00000026122
resolver
ensp
ENSRNOP00055046808
resolver
enst
ENSRNOT00055056703
resolver
genesymbol
Hmgcs2
resolver
uniprot
F1M9Q5
resolver
uniprot
Q68G44
resolver
uniprot_entry
HMCS2_RAT
resolver
uniprot_sec
F1M9Q5
resolver
uniprot_sec
Q68G44
resolver
amino_acid_sequence
MQRLLAPARRVLQVKRVMQESSLSPAHLLPAAQQRFSTIPPAPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLVLEQGLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRRKIQNQWKQAGNNQPFTLDDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSSDKQNNLYKGLEAFKGLKLEETYTNKDVDKALLKASLDMFNKKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKRLDSRRRMSPEEFTEIMNQREQFYHKVNFSPPGDTSNLFPGTWYLERVDEMHRRKYARRPV
uniprot
proteins
ec_number
2.3.3.10
uniprot
proteins
function
FUNCTION: Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. {ECO:0000250|UniProtKB:P54868}.
uniprot
proteins
mass_dalton
56886
uniprot
proteins
pathway_participation
PATHWAY: Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3. {ECO:0000305}.
uniprot
proteins
post_translational_modification
PTM: Succinylated. Desuccinylated by SIRT5. Succinylation, at least at Lys-83 and Lys-310, inhibits the enzymatic activity. {ECO:0000250|UniProtKB:P54869}.
uniprot
proteins
protein_family
HMG-CoA synthase family
uniprot
proteins
protein_family
Thiolase-like superfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1971108
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8097464
uniprot
proteins
sequence_length
508
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305|PubMed:1971108}.
uniprot
proteins