Fbxo46
entrez
243867
canonical
uniprot
Q8BG80
canonical
ensembl
ENSMUSG00000050428
resolver
ensp
ENSMUSP00000055692
resolver
ensp
ENSMUSP00000129427
resolver
ensp
ENSMUSP00000260913
resolver
enst
ENSMUST00000053109
resolver
enst
ENSMUST00000165913
resolver
genesymbol
Fbxo46
resolver
genesymbol_syn
Fbx46
resolver
genesymbol_syn
Fbxo34l
resolver
uniprot_entry
FBX46_MOUSE
resolver
amino_acid_sequence
MDRGSLLPFQLWCPRPFSKYSQNQPRPPSTALKPPVCPDTSSGTEPDHRPAHLESTPPAVAAEAPTSQPAPLLSTAASGDEGRVLLDTWYVIKPGNTKEKVAFFVAHQCGGSSRASSMKVKGHWGSDSSKAKRRRRCLEPTKAPPDQGGREGTPATEVTPTSSGDDVDLVSVAEMVALVEQRAALALQSYPRPSTPAPVVFVSADQGGPAKGLGSERRSGGGDCSRVAEAVAHFEAQRDSPPTKGLRKEERPGPGPGEVRIAFRISNVREPHSPDGNLPNGGGGRPGCAYPGSPGPGTRAKDKITCDLYQLISPSRDALPSNVEFLLARADEASEGETPAPTRPEDTPPAPPPPPARDCGASGFHVDVVVTGVVDACIFFGKDGTKNVKEETVCLTVSPEEPPPPGQLFFLQSRGPEGPPEPPPADIPSTVPGPDDSEGTTDTSLCRLYRHVSHDFLEIRFKIQRLLEPRQYMLLLPEHVLVKIFSFLPTRALAALKCTCHHFKGIIEAFGVRATDSRWSRDPLYRDDPCKQCRKRYEKGDVSLCRWHPKPYHHDLPYGRSYWMCCRRADRETPGCRLGLHDNNWVLPCNGVGGGRAGREEGR
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins. In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31. {ECO:0000250|UniProtKB:Q6PJ61}.
uniprot
proteins
mass_dalton
65294
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q6PJ61}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ATM in response to DNA damage, promoting ubiquitination and degradation by the SCF(FBXO31) complex. {ECO:0000250|UniProtKB:Q6PJ61}.; PTM: ATM-phosphorylated FBXO46 is ubiquitinated and degradaded by the SCF(FBXO31) complex in response to DNA damage. {ECO:0000250|UniProtKB:Q6PJ61}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
603
uniprot
proteins