Trpv4
entrez
66026
canonical
uniprot
Q9ERZ8
canonical
ensembl
ENSRNOG00000001195
resolver
ensembl
ENSRNOG00055001978
resolver
ensembl
ENSRNOG00060004776
resolver
ensembl
ENSRNOG00065007095
resolver
ensp
ENSRNOP00000001586
resolver
ensp
ENSRNOP00000095633
resolver
ensp
ENSRNOP00055002364
resolver
ensp
ENSRNOP00060005981
resolver
ensp
ENSRNOP00065008117
resolver
enst
ENSRNOT00055003153
resolver
enst
ENSRNOT00060007995
resolver
enst
ENSRNOT00065011080
resolver
genesymbol
Trpv4
resolver
genesymbol_syn
Vroac
resolver
uniprot_entry
TRPV4_RAT
resolver
amino_acid_sequence
MADPGDGPRAAPGDVAEPPGDESGTSGGEAFPLSSLANLFEGEEGSSSLSPVDASRPAGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDNKRWRRKVVEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLSYLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCSRLFPDSNLETVLNNDGLSPLMMAAKTGKIGVFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEVSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLLTGVLFFFTSIKDLFMKKCPGVNSLFVDGSFQLLYFIYSVLVVVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVTLLNPCTNMKVCNEDQSNCTVPSYPACRDSETFSAFLLDLFKLTIGMGDLEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKSEIYQYYGFSHTMGRLRRDRWSSVVPRVVELNKNSGTDEVVVPLDNLGNPNCDGHQQGYAPKWRAEDAPL
uniprot
proteins
function
FUNCTION: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:11081638). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:11081638). Also activated by heat, low pH, citrate and phorbol esters (By similarity). Increase of intracellular Ca(2+) potentiates currents (By similarity). Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (By similarity). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (By similarity). Together with PKD2, forms mechano- and thermosensitive channels in cilium (By similarity). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (By similarity). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (By similarity). In neurons of the central nervous system, could play a role in triggering voluntary water intake in response to increased sodium concentration in body fluid (By similarity). {ECO:0000250|UniProtKB:Q9EPK8, ECO:0000250|UniProtKB:Q9HBA0, ECO:0000269|PubMed:11081638}.
uniprot
proteins
mass_dalton
98010
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9EPK8}.
uniprot
proteins
protein_family
TRPV4 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
protein_family
TrpV subfamily
uniprot
proteins
pubmed
11081638
uniprot
proteins
pubmed
16627472
uniprot
proteins
sequence_length
871
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9HBA0}. Apical cell membrane {ECO:0000305|PubMed:11081638}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9HBA0}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9EPK8}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9HBA0}. Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. Localization to the cell membrane is inhibited by WNK kinases (WNK1, WNK2, WNK3 or WNK4) in a kinase-independent mechanism. {ECO:0000250|UniProtKB:Q9HBA0}.
uniprot
proteins
transmembrane_region
TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O35433"; TRANSMEM 508..534; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O35433"; TRANSMEM 548..568; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O35433"; TRANSMEM 573..593; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O35433"; TRANSMEM 609..636; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O35433"; TRANSMEM 694..722; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O35433
uniprot
proteins